SGTCid condition conc unit HPM1|YIL110W.score HPM1|YIL110W.strain.pval HPM1|YIL110W.strain.significant HPM1|YIL110W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_800 3448-7362 155 µM 5.65829986343198 5.49437998715131e-08 yes 1 7.6439927238625e-09 62 15991913 SGTC_598 3937-0236 20.2 µM 5.59941759035475 7.40692806206605e-08 yes 2 1.07536572185115e-08 10 1379313 SGTC_1635 st007035 42.4 µM 5.50596009716698 1.18287759851159e-07 yes 3 1.83580847069474e-08 146 3716403 SGTC_150 3970-0969 77.2 µM 5.29105590391374 3.37595946476476e-07 yes 4 6.08060914095442e-08 32 6615640 SGTC_558 k064-0027 21.3 µM 5.23300516722983 4.45198511172845e-07 yes 5 8.33880376754253e-08 10 5088526 SGTC_1971 st069429 63.5 µM 5.16563777281376 6.11595028243046e-07 yes 6 1.19810224193246e-07 4 1246522 YGL099W LSG1 SGTC_451 chloral hydrate 100 µM 5.07932427724787 9.13605552465296e-07 yes 7 1.89389846419889e-07 26 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_881 0833-0569 170 µM 5.06485239127256 9.76603614184654e-07 yes 8 2.04358460563307e-07 5 5418700 SGTC_1106 tegaserod maleate 11.7 µM 4.99319868034337 1.35515403530539e-06 yes 9 2.96937043672722e-07 3 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2688 kanamycin b 96.69 µM 4.82451880912522 2.88129079404328e-06 yes 10 7.01708368225452e-07 261 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2907 7721985 69.9 µM 4.80675240686026 3.1152600641704e-06 yes 11 7.67008878707184e-07 6 3267881 SGTC_547 1120-0019 610 nM 4.73348843725363 4.28664165809741e-06 yes 12 1.10346770722085e-06 19 3676939 SGTC_3017 9080681 49.47 µM 4.69181726103153 5.1298054380755e-06 yes 13 1.3539447339446e-06 8 16451914 SGTC_2555 cholic acid 100 µM 4.63640762442221 6.49870824428885e-06 yes 14 1.77258259701961e-06 11 6708657 Influences liver metabolism. SGTC_1670 st016595 4.04 µM 4.58019758561103 8.23965589851881e-06 yes 15 2.32268431139579e-06 5 597879 SGTC_3002 9075603 71.4286 µM 4.25804536786479 3.05371444487842e-05 yes 16 1.03111052028224e-05 13 20105405 SGTC_245 methotrexate 289.6 µM 4.25335299827934 3.11057407298997e-05 yes 17 1.05296601923935e-05 37 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3190 9110366 49.47 µM 4.14074946229133 4.81670393817441e-05 yes 18 1.73086450568963e-05 9 17123768 SGTC_1746 st038117 42 µM 4.03692738414691 7.1423580562667e-05 yes 19 2.70779111948452e-05 31 2898218 SGTC_81 0411-0046 9.971 µM 4.03361556443251 7.23162796349688e-05 yes 20 2.74625746750758e-05 23 12925265 SGTC_1018 4259-0013 28.1 µM 3.96509253268204 9.3319862312441e-05 yes 21 3.6683740268455e-05 18 6801262 SGTC_2908 7930301 100 µM 3.94039785906305 0.000102205232958648 yes 22 4.06732908363503e-05 26 2223178 SGTC_127 0180-0333 59.125 µM 3.88576108504775 0.00012476552487946 yes 23 5.10048965987284e-05 43 771601 SGTC_309 k408-0051 1.48 µM 3.87139615994024 0.000131429512071821 yes 24 5.41068774738212e-05 50 3640463 SGTC_1272 0839-0021 27 µM 3.82554750047182 0.000154999554481891 yes 25 6.52408855616143e-05 21 5027250 SGTC_34 0469-0683 81.75 µM 3.80729366378734 0.00016544142741539 yes 26 7.02479375807558e-05 33 3690923 SGTC_262 fenpropimorph 62.5 µM 3.67898880039629 0.000259616042003023 yes 27 0.000117080274776165 34 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3027 9089541 49.47 µM 3.65225029667609 0.000284694815150435 yes 28 0.000129976162321304 27 9943819 SGTC_830 4076-0286 57.8 µM 3.64157089550766 0.000295327751174235 yes 29 0.000135489738840368 78 6866659 SGTC_246 cycloheximide 667 µM 3.6185362606652 0.000319532882070621 yes 30 0.000148136996383421 22 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2369 9071472 200 µM 3.5332328371244 0.000426167136377479 yes 31 0.000205255379999822 25 17296037 SGTC_2088 5278280 127.392 µM 3.50351551804052 0.000470486317349153 yes 32 0.000229579950760662 40 791502 SGTC_2337 9009472 200 µM 3.47546136099365 0.000516207487622602 yes 33 0.000254987726408915 50 5742383 SGTC_3031 9088762 49.47 µM 3.43803918585393 0.000583607239998489 yes 34 0.000292971449487814 40 205253 SGTC_2754 granisetron 64.02 µM 3.43232991992988 0.00059457756481445 yes 35 0.000299209548022447 51 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2417 cerulenin 830 nM 3.42984513435865 0.000599411312447048 yes 36 0.000301962916530638 40 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_770 0389-1121 67.2 µM 3.40104299182229 0.000658153195980801 yes 37 0.000335646347462584 50 6753108 SGTC_1920 st075728 45.7 µM 3.37684137445723 0.000711571836695476 yes 38 0.000366616611286539 48 3400306 SGTC_2489 cantharidin 73.42 µM 3.37432727952202 0.000717344371643032 yes 39 0.000369981677301635 69 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2514 salinomycin 42.74 µM 3.36703081928608 0.00073434287206603 yes 40 0.000379910981792666 81 23682228 A polyether potassium ionophore. SGTC_562 3772-2733 112 µM 3.32152209062508 0.000849017505081623 yes 41 0.000447639475123409 111 2876874 YIL048W NEO1 SGTC_2368 9071271 200 µM 3.30746532166192 0.000887636286655392 yes 42 0.000470721836521367 65 27209959 SGTC_2702 st077768 96.8 µM 3.29098628573351 0.000934962913378981 yes 43 0.00049918390186397 39 6484119 SGTC_3021 9087658 49.47 µM 3.28953043782731 0.000939253524208536 yes 44 0.000501773508676043 14 25237042 SGTC_2089 5281248 129.67 µM 3.28718004348077 0.000946218688803106 yes 45 0.000505980560114277 47 2737878 SGTC_3346 9158254 43.5805 µM 3.20335666451083 0.00122789977191168 no 46 0.000679178194279289 50 17639500 SGTC_2467 5474540 200 µM 3.17934753407521 0.00132168001455097 no 47 0.000738034996487909 52 5413519 SGTC_3278 9139605 49.47 µM 3.17869180204799 0.00132433080568593 no 48 0.000739706512180849 43 7958859 SGTC_1967 st070177 51.4 µM 3.16736290658547 0.00137090167166992 no 49 0.000769141102520449 46 5729214 SGTC_2408 sulbentine 18.36 µM 3.14973592174448 0.00144634422401278 no 50 0.000817090522703745 85 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1414 3917-0015 5.4 µM 3.13125936052359 0.00152947446227308 no 51 0.000870291834678715 32 6618702 SGTC_2050 5263056 171 µM 3.11706839744745 0.00159625632060864 no 52 0.000913295942410286 91 763468 YGL055W OLE1 SGTC_88 0180-0332 8.668 µM 2.99058046150959 0.00231977522083838 no 53 0.00139223880488854 62 3101745 SGTC_2730 imipramine 71.33 µM 2.97988319793462 0.00239288071705271 no 54 0.00144179156174728 76 3696 A tricyclic antidepressant. SGTC_1846 st056244 14.8 µM 2.96736941893954 0.002481042187993 no 55 0.00150179918214493 80 5393182 SGTC_2977 9011197 71.43 µM 2.96573404967755 0.00249277809125853 no 56 0.00150980742722551 49 2704722 SGTC_2099 5377090 177.372 µM 2.96127085942446 0.00252506317723143 no 57 0.00153186186011535 70 2243829 SGTC_1062 mesoridazine 14.2 µM 2.95666727528582 0.00255875941505388 no 58 0.00155491748533908 65 4078 A neuroleptic. SGTC_579 4491-1009 110 µM 2.92807369723545 0.00277730914739041 no 59 0.00170534595629882 78 1271041 SGTC_108 0509-0257 621.132 µM 2.88841649125095 0.00310830763370735 no 60 0.00193593411850241 109 536624 SGTC_2265 7929201 200 µM 2.88454041976491 0.003142492898567 no 61 0.00195992717642983 76 1265108 SGTC_228 caffeine 993.056 µM 2.87025731365268 0.00327140411422873 no 62 0.0020506894718467 40 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_625 k213-0058 121 µM 2.86712267670997 0.00330032424585871 no 63 0.00207111206756225 219 3655420 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.86456715430025 0.00332407135883522 no 64 0.00208789801101733 56 756377 SGTC_2145 5634607 200 µM 2.83207454290601 0.00363968778389523 no 65 0.00231235329408093 46 308662 SGTC_686 1319-0111 510 µM 2.83030999601767 0.00365757334308847 no 66 0.00232514614841068 78 4562600 SGTC_168 3970-0862 530.542 µM 2.81883367138569 0.00377583482331576 no 67 0.0024099243288564 251 3135186 SGTC_801 0866-0028 10.1 µM 2.80818707956531 0.00388859960879152 no 68 0.00249106374936649 107 6849771 SGTC_2270 7924575 90.91 µM 2.78959330145487 0.00409279340158853 no 69 0.00263871440526748 78 1262135 SGTC_2406 ethylparaben 405.7 µM 2.77487210768664 0.00426120982396707 no 70 0.00276117097193714 104 8434 A possible steroid mimic. SGTC_1564 D-Arginine 115 µM 2.76760719602443 0.00434658520256016 no 71 0.00282347356012638 100 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1999 st074831 12.5 µM 2.75688628928698 0.00447536790677253 no 72 0.00291773203101751 102 17112523 SGTC_2814 7977482 42.97 µM 2.74216661948803 0.00465773418353566 no 73 0.00305176861606651 143 6456762 SGTC_2823 7987624 58.44 µM 2.7136206466269 0.0050303942981489 no 74 0.00332761647158561 120 2239440 SGTC_1621 st003705 32.4 µM 2.70520014710239 0.00514528081253704 no 75 0.00341316230384378 104 24207032 SGTC_2692 st077426 47.7 µM 2.68800370792597 0.00538718284926364 no 76 0.00359402992340832 94 25238571 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.67957372219401 0.00550941968366148 no 77 0.00368579843777218 109 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_449 xestospongin c 11.1929 µM 2.65507966459484 0.00587868725833058 no 78 0.00396448404425839 155 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1893 st059353 36.1 µM 2.64412116899059 0.00605088704644103 no 79 0.00409516654134037 100 3112488 SGTC_1738 st035555 74 µM 2.64404975555122 0.006052023733116 no 80 0.00409603065893058 118 5331140 SGTC_2093 5331342 194.4 µM 2.61785285805744 0.00648198731811168 no 81 0.00442424755819363 82 33839 SGTC_1786 berberine 21.6 µM 2.61560734463673 0.00652007035778704 no 82 0.00445344595935029 132 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1363 1636-0063 10.4 µM 2.61549275044667 0.00652201912734039 no 83 0.00445494063249379 126 6072185 SGTC_2086 5274770 176.623 µM 2.60791520895572 0.00665203031528287 no 84 0.00455477581376143 109 689278 SGTC_1416 3966-0321 25.3 µM 2.57990580032336 0.00715270176418848 no 85 0.00494136345817291 112 582530 YLR208W SEC13 SGTC_1064 honokiol 6.76 µM 2.57940933547435 0.00716186817011894 no 86 0.00494847171914211 111 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1849 st056239 19.2 µM 2.56396099326703 0.00745232250295799 no 87 0.00517425869484588 133 5393181 SGTC_2679 rapamycin 1 nM 2.56353554143229 0.00746046647186058 no 88 0.00518060460582001 276 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.54457157426717 0.00783152959955217 no 89 0.00547059431343701 116 115019 SGTC_2870 9038528 12.99 µM 2.53626077034302 0.00799919790785703 no 90 0.00560216333892973 106 6463316 SGTC_1361 1608-0041 5.61 µM 2.52481275086715 0.0082353233113847 no 91 0.00578799753331338 106 X1361 SGTC_2605 digitonin 300 nM 2.51303805536579 0.00848455225785145 no 92 0.00598482111614454 143 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_633 0437-0093 97.7 µM 2.47947429223219 0.00923165669632211 no 93 0.00657881072897648 97 2831118 SGTC_2290 7904846 200 µM 2.47689359586668 0.00929141531310895 no 94 0.00662657030605313 146 2962154 SGTC_2281 7943571 200 µM 2.47466009304791 0.00934340727514834 no 95 0.00666815172651729 91 1244024 SGTC_2415 st077333 57.7 µM 2.45419179250286 0.00983184813056208 no 96 0.00706008243719243 186 2766255 SGTC_3352 9151559 45.5865 µM 2.4452762135262 0.0100514824839683 no 97 0.00723706215901973 99 17159339 SGTC_1136 pergolide 1.05886 µM 2.43866843565513 0.0102170156072493 no 98 0.0073707434817131 192 47811 A dopamine receptor agonist. SGTC_377 3970-0964 33.1 µM 2.4313760127847 0.0104024552963074 no 99 0.00752079773212249 205 16481235 SGTC_3269 9137823 49.47 µM 2.42446487572342 0.0105809000863051 no 100 0.00766548314549977 108 17682936 SGTC_1887 st057648 70.8 µM 2.42204088533477 0.0106441158836459 no 101 0.00771680700698582 110 688672 SGTC_2347 9049783 174.81 µM 2.40804863681249 0.0110154909991386 no 102 0.00801902212242684 165 6467988 YPL169C MEX67 SGTC_1484 3473-2379 286 µM 2.40470261337998 0.0111059517677709 no 103 0.00809281555674261 122 671917 SGTC_2258 7960471 200 µM 2.40007560096687 0.0112321084963039 no 104 0.00819584303004077 95 2974708 SGTC_422 cantharidin 155 µM 2.38290050146067 0.0117113487103275 no 105 0.00858841811973489 203 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1407 3909-7909 12.3 µM 2.3674803970958 0.0121566400162998 no 106 0.00895483438786097 118 4411780 SGTC_3014 9081533 49.47 µM 2.36379419822874 0.0122652357980146 no 107 0.00904442900537304 98 21367265 SGTC_3351 9150312 21.596 µM 2.34899493878684 0.0127097276139455 no 108 0.00941208134095408 152 4904905 SGTC_2608 thymoquinone 42.66 µM 2.29937165672042 0.0143033593413143 no 109 0.010741921992036 134 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3354 9151612 71.43 µM 2.29682165959568 0.014389706375469 no 110 0.010814472719926 135 27261949 SGTC_66 0109-0187 42.4 µM 2.2965303251263 0.0143995999422037 no 111 0.0108227886516638 163 759417 SGTC_335 4077-0256 27.6 µM 2.29283121080296 0.014525730109562 no 112 0.0109288621976146 147 3121989 SGTC_1391 3442-0225 151 µM 2.2882153075108 0.01468445304439 no 113 0.0110624928533319 127 5227075 SGTC_3181 9108277 49.47 µM 2.28766776407699 0.0147033795600128 no 114 0.0110784381686208 138 17097298 SGTC_2720 fluspirilene 36.88 µM 2.27755764394694 0.0150566380053781 no 115 0.0113764732535128 97 3396 An atypical antipsychotic. SGTC_3133 9127736 49.47 µM 2.27503276777591 0.0151459897690561 no 116 0.0114519821093118 137 27243420 SGTC_1567 st069303 68.4 µM 2.2680778021046 0.0153944755178305 no 117 0.0116622325328564 162 5581319 SGTC_902 1120-0002 2.07 µM 2.26415464251586 0.0155361794941925 no 118 0.0117823025895124 195 3280475 SGTC_1624 st003710 6.25 µM 2.25757480578279 0.0157763558192085 no 119 0.0119860904278651 199 24207033 SGTC_220 paclitaxel 373.376 µM 2.24731935217125 0.0161570471647665 no 120 0.0123098124848429 108 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1861 st057647 17.4 µM 2.23369483045337 0.0166749547983841 no 121 0.0127515796910045 166 688668 SGTC_1456 k015-0012 13 µM 2.23220405427425 0.0167324763605237 no 122 0.0128007397959132 182 2989616 SGTC_2395 5646831 180.19 µM 2.23023008610987 0.0168089030027333 no 123 0.0128660859376236 182 6808628 SGTC_791 1348-1292 225 µM 2.22832085288892 0.0168831071354413 no 124 0.0129295633730862 231 5437054 SGTC_2994 9053520 71.4286 µM 2.22486345676746 0.0170181951203112 no 125 0.0130452029368415 153 4647384 SGTC_939 1165-0479 45.3 µM 2.22269938044444 0.0171032196047266 no 126 0.0131180388573093 204 1377347 SGTC_20 0481-0013 4.944 µM 2.21077897520527 0.0175780960949231 no 127 0.0135255732323156 175 182045 SGTC_758 0868-0029 16 µM 2.20442415337431 0.0178358225836111 no 128 0.0137472642939489 142 762687 SGTC_1081 sertraline 6 µM 2.18848251517865 0.018496575487894 no 129 0.0143172367616415 201 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3123 9126162 49.47 µM 2.18495011361822 0.0186457757660535 no 130 0.0144462522627108 156 25239884 SGTC_712 r015-0009 80.6 µM 2.15789817576861 0.0198227070147436 no 131 0.015467874685221 141 6813872 YLR060W FRS1 SGTC_3095 9117207 49.47 µM 2.14268595765827 0.0205118124159131 no 132 0.0160691618474505 116 17015229 SGTC_3286 9117135 37.221 µM 2.14252303106155 0.0205193013912636 no 133 0.0160757086988625 180 3438150 SGTC_1418 3966-3099 2.4 µM 2.13885072099961 0.0206887159239263 no 134 0.0162238800699952 199 740335 SGTC_2171 5739187 198.077 µM 2.13830705079892 0.0207138974312305 no 135 0.0162459153432572 140 2262761 SGTC_1216 1165-0504 9.65 µM 2.1325472533411 0.0209822753391722 no 136 0.0164809421118227 175 6304004 SGTC_359 0081-0058 15.9 µM 2.12363381242214 0.021403395299506 no 137 0.0168503879404334 216 3494159 SGTC_2715 st079500 56.4 µM 2.1204463601528 0.0215557125490037 no 138 0.0169842102806315 154 28246688 SGTC_287 k060-0039 29.6 µM 2.11818295351992 0.0216644282425447 no 139 0.0170797881423986 161 5861974 SGTC_1100 amiodarone 5.07 µM 2.11773794953051 0.0216858570298227 no 140 0.0170986334981732 197 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1417 3966-0327 90.4 µM 2.11264778800826 0.0219322459305312 no 141 0.0173154626280656 203 651118 SGTC_1643 st009866 20.2 µM 2.11090453415963 0.0220171695750175 no 142 0.0173902591436971 146 3156273 YOR207C RET1 SGTC_1178 0988-0033 191 µM 2.08729208693866 0.0231950747547501 no 143 0.0184308698227479 235 5392207 SGTC_1668 st014914 51.6 µM 2.08589890130769 0.0232662004580614 no 144 0.018493890922356 158 2839556 SGTC_250 brefeldin a 552.239 µM 2.08022697784154 0.0235576646119119 no 145 0.0187523594437604 143 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2279 7948423 32.93 µM 2.06812912069159 0.0241896109761344 no 146 0.019313941519128 152 1247112 SGTC_2909 7941780 10.49 µM 2.05864126982794 0.0246951284570826 no 147 0.0197643080912434 208 1243215 SGTC_826 1683-5028 118 µM 2.05326936307825 0.0249852556223965 no 148 0.0200232302352263 183 722377 SGTC_2624 nerol 100 µM 2.05312708414077 0.0249929785379284 no 149 0.0200301269106722 169 637566 A natural product oil. SGTC_1768 st044301 37.178 µM 2.05194380617567 0.0250572845567421 no 150 0.0200875619512481 202 3931349 SGTC_184 1494-0393 24.714 µM 2.04643860900048 0.0253582946456444 no 151 0.0203566183639002 256 3090647 SGTC_2338 7999974 200 µM 2.04571133636691 0.0253982856445924 no 152 0.0203923898664808 214 315925 SGTC_140 0062-0056 502.533 µM 2.03826537463493 0.0258107688755739 no 153 0.0207617003400769 231 3758964 SGTC_2915 7971052 15.16 µM 2.03357458680655 0.0260734911700338 no 154 0.0209972531405096 117 5741558 SGTC_3300 9124615 50.48 µM 2.02733517982197 0.026426411404655 no 155 0.0213140730291911 235 24824903 SGTC_2623 humulene 100 µM 2.01833697427476 0.0269424008944602 no 156 0.0217780892234802 160 6187145 An anti-inflammatory. SGTC_392 N-ethylmaleimide 8.33 µM 2.01719789693728 0.0270083154108466 no 157 0.0218374327345229 195 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3024 9090631 49.47 µM 2.00971903332162 0.0274444424911698 no 158 0.0222304671681131 149 25236383 SGTC_2829 7992743 58.44 µM 2.00290453023558 0.0278469254804526 no 159 0.0225937683760997 253 16462845 SGTC_2782 7736369 71.43 µM 2.00207905825992 0.0278960123272201 no 160 0.022638114715821 263 2950836 YOL077C BRX1 SGTC_1160 4092-0570 10.5 µM 2.00077110500591 0.0279739375847245 no 161 0.0227085313344377 253 4994975 SGTC_507 nimesulide 162 µM 1.99853509117698 0.0281075747138628 no 162 0.0228293397386115 218 4495 A COX2 inhibitor. SGTC_1701 st028638 40.4 µM 1.99416608840459 0.0283702257943309 no 163 0.0230669533959094 225 3490878 SGTC_174 3553-0389 74.3 µM 1.99290793965236 0.0284462395118168 no 164 0.0231357643827811 191 738071 SGTC_1844 rapamycin 4 nM 1.99020824657865 0.0286099191868655 no 165 0.0232840001336354 402 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_871 0574-0004 149 µM 1.98942916466624 0.0286572995235585 no 166 0.0233269265967718 259 9551173 SGTC_2964 9083345 53.42 µM 1.98733423095129 0.0287850279230026 no 167 0.0234426853498942 208 17741579 SGTC_1935 st074532 41.6 µM 1.98583257010763 0.0288768753377029 no 168 0.023525958980832 272 2829742 SGTC_835 0312-0010 67.2 µM 1.98516333840314 0.0289178865561993 no 169 0.0235631508736755 189 1626196 SGTC_3323 9138564 53.9225 µM 1.98259738744367 0.0290755796180084 no 170 0.0237062097199929 248 43912313 YNL103W MET4 SGTC_1969 st069479 40.1 µM 1.98213939692428 0.0291038008892366 no 171 0.0237318206126427 179 3895485 SGTC_1281 0884-0031 11.8 µM 1.9773723475926 0.0293988988771816 no 172 0.023999778646445 246 1548255 SGTC_3076 9116187 49.47 µM 1.97563384565932 0.0295071349655542 no 173 0.0240981312140028 191 27241210 SGTC_828 2074-0507 139 µM 1.97173431094192 0.0297511166514087 no 174 0.0243199723235001 247 X828 SGTC_2958 9077254 16.72 µM 1.97043312139548 0.0298328995174071 no 175 0.0243943763695717 237 16457351 SGTC_3207 9114163 49.47 µM 1.96723258921281 0.0300348543643307 no 176 0.0245782012688953 286 849233 SGTC_290 2043-6722 48.1 µM 1.96509513788695 0.0301703587233269 no 177 0.0247016136293475 212 773758 YLR208W SEC13 SGTC_2954 9074818 52.69 µM 1.96460026275756 0.0302018036208825 no 178 0.0247302607724255 259 16648742 SGTC_2780 5215298 71.43 µM 1.95655313926125 0.0307169502200289 no 179 0.0252000145202602 269 2834131 SGTC_1530 rhein 70.4 µM 1.95603752119116 0.0307502046754662 no 180 0.0252303671179746 226 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1372 2752-0194 270 µM 1.95153862827846 0.031041624363798 no 181 0.0254965028763212 202 823334 SGTC_462 ag-879 158 µM 1.93866990385637 0.031887846996606 no 182 0.0262707728011755 270 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_492 tmb-8 126 µM 1.93283683807232 0.0322776465320743 no 183 0.0266281503595423 96 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_998 3996-0085 177 µM 1.93177445912942 0.0323490625208654 no 184 0.0266936749168933 259 715391 SGTC_1340 1486-1359 257 µM 1.92542904831346 0.0327783381317121 no 185 0.0270878522103434 238 4309068 SGTC_3326 9140064 16.379 µM 1.916346238646 0.0334009650694331 no 186 0.0276605194999709 221 1868434 SGTC_980 1473-0395 201 µM 1.91540761326267 0.0334658593958916 no 187 0.0277202704932118 183 768876 SGTC_1583 clindamycin 39.6 µM 1.91169910105104 0.0337232731331388 no 188 0.0279573998545747 225 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1675 st018485 24.5 µM 1.90728738837791 0.0340316167523524 no 189 0.0282416912184066 265 3323024 SGTC_1189 1431-2119 7.28 µM 1.90274099696771 0.0343517951775104 no 190 0.0285371748061067 306 3107275 SGTC_1231 0242-0792 125 µM 1.90243888436643 0.0343731588013096 no 191 0.0285569007957084 247 3707635 SGTC_1465 k213-0056 144 µM 1.89788866615713 0.0346962460618472 no 192 0.0288553748478081 260 24048857 YMR208W ERG12 SGTC_134 0269-0018 6.916 µM 1.89719293911853 0.0347458651207163 no 193 0.0289012392088645 364 4378915 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.89591195483646 0.0348373769683452 no 194 0.0289858439311526 120 6708630 An antioxidant. SGTC_932 2857-0803 154 µM 1.89440811000822 0.034945062092052 no 195 0.0290854303962971 260 674898 SGTC_1631 benzylvanillin 81.9 µM 1.87666289622939 0.0362364879276027 no 196 0.0302821555153232 288 75506 SGTC_1466 k213-0079 57.5 µM 1.8729482044404 0.0365117147808395 no 197 0.0305377688718554 258 3657981 SGTC_74 000s-0487 160.283 µM 1.87106879585714 0.0366516131183415 no 198 0.0306677730183451 268 677548 SGTC_465 cgp-37157 41 µM 1.86575695994741 0.0370493849218512 no 199 0.0310376882420751 159 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.85678858490856 0.0377289763009127 no 200 0.0316706191983566 270 5355888 SGTC_62 0180-0423 3.232 µM 1.85237695643279 0.0380669885159516 no 201 0.031985855962149 257 30102 YGL099W LSG1 SGTC_1309 pyrazolanthrone 13.4 µM 1.84891363958346 0.038334069847633 no 202 0.0322351419305627 278 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3169 9102970 49.47 µM 1.84601932728579 0.0385584412234227 no 203 0.0324446995886004 189 17027839 SGTC_778 3456-2434 196 µM 1.84159630811687 0.0389033865246175 no 204 0.032767110740492 355 5539063 SGTC_528 3492-0019 172 µM 1.82699557985466 0.0400599557549263 no 205 0.0338502169943425 538 2869262 SGTC_2722 naftopidil 47.16 µM 1.82663712733476 0.0400886975041767 no 206 0.0338771736086123 262 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1406 3909-7906 11.9 µM 1.82580954717966 0.040155119247854 no 207 0.0339394773614033 273 X1406 SGTC_2580 diallyl disulphide 81.36 µM 1.82507747471611 0.0402139500233434 no 208 0.0339946694166383 268 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1413 3910-0535 34.4 µM 1.81589316300314 0.0409579849412 no 209 0.0346933811517041 275 2876951 SGTC_2508 celastrol 40.54 µM 1.81572751993901 0.0409715057541405 no 210 0.0347060901863321 226 122724 Celastrol is a natural product and antioxidant. SGTC_1114 scopoletin 1.73284 µM 1.81433228996469 0.0410855367962892 no 211 0.0348132915974289 244 5280460 A coumarin with genotoxic properties. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.81394070274465 0.0411175871210662 no 212 0.0348434277080956 353 368090 SGTC_1799 st045822 46.1415 µM 1.8135634941616 0.0411484797620149 no 213 0.0348724775037261 245 3674992 SGTC_851 0394-0702 453 µM 1.80132619421119 0.0421609414147919 no 214 0.0358257407724204 286 762646 SGTC_988 1497-1057 103 µM 1.80067912381007 0.0422150335015382 no 215 0.035876734942665 293 3533044 SGTC_1038 k292-0204 154 µM 1.79635976584285 0.0425775518780817 no 216 0.0362186591712744 280 4454212 SGTC_1198 1612-1005 86.7 µM 1.79114908782536 0.0430182232304052 no 217 0.03663468683925 268 6998509 SGTC_696 1560-0013 611 µM 1.78133736385086 0.0438580070946245 no 218 0.0374286770218298 293 1650269 SGTC_911 3456-4043 236 µM 1.77584232195227 0.0443340733788008 no 219 0.0378794549257341 330 914281 SGTC_607 4491-0986 66.8 µM 1.77133131447297 0.0447279923223318 no 220 0.0382528115203063 295 698981 YDR232W HEM1 SGTC_3195 9113082 49.47 µM 1.76981681117481 0.0448608749842677 no 221 0.0383788312176744 239 17018038 SGTC_1958 st076513 41.9 µM 1.7641591763101 0.04536009015313 no 222 0.0388525918635532 329 732122 YGL099W LSG1 SGTC_1495 4469-0029 237 µM 1.76233753793089 0.0455217745197596 no 223 0.0390061425868602 447 793680 SGTC_1475 4092-1048 11.7 µM 1.75662481771419 0.0460318295249359 no 224 0.0394908899689114 342 2881759 SGTC_1429 4049-0205 9.46 µM 1.75610991197577 0.0460780270723755 no 225 0.0395348214943375 303 22774478 SGTC_2729 fluphenazine 10.66 µM 1.74519787483494 0.0470658459853388 no 226 0.0404752155234608 316 3372 An atypical antipsychotic. SGTC_2127 5253358 187.912 µM 1.74470497162923 0.0471108640724994 no 227 0.0405181187301119 289 20612 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.73633249922565 0.0478808291225983 no 228 0.0412525299880096 314 390807 SGTC_25 0118-0223 35.662 µM 1.73057090169324 0.0484165157389815 no 229 0.0417641626474631 299 5333628 SGTC_211 3455-0679 143.504 µM 1.72701953805851 0.0487490857436551 no 230 0.0420820773090357 338 748649 SGTC_1308 1187-1617 41.4 µM 1.72443015903813 0.0489927190249269 no 231 0.0423151084876595 369 2882570 SGTC_1511 0906-3109 28.5 µM 1.72180436719957 0.0492407707531874 no 232 0.0425524816110877 434 2882180 SGTC_603 3794-0023 45.9 µM 1.72008338020294 0.0494038912642809 no 233 0.042708643159965 277 3802260 SGTC_1132 3456-3614 2.5 µM 1.71984864028378 0.0494261740394923 no 234 0.0427299792094755 410 3125502 SGTC_934 2950-0684 338 µM 1.71740779650981 0.0496583477729621 no 235 0.0429523440686876 335 1121253 SGTC_2391 6285546 200 µM 1.71342414488538 0.050039142111905 no 236 0.0433172687377976 351 846083 SGTC_2785 7756463 72.73 µM 1.70568284750904 0.0507857832677516 no 237 0.0440335724538509 317 2201551 SGTC_831 k061-1017 217 µM 1.70360902043997 0.0509873013108879 no 238 0.0442270775663156 488 1240153 SGTC_1685 st024049 53.0905 µM 1.70132995105303 0.0512094967113741 no 239 0.0444405234178499 289 1941139 SGTC_691 1548-0686 185 µM 1.69885507962534 0.0514516534512018 no 240 0.0446732462989228 370 46495133 SGTC_1961 st076550 68.7 µM 1.69587123340236 0.051744821347938 no 241 0.0449551342761677 283 1579337 SGTC_667 1498-1044 59 µM 1.69083986135345 0.0522421676218638 no 242 0.045433695872543 330 6739982 SGTC_580 1123-0028 41 µM 1.68526362850433 0.0527978000085668 no 243 0.0459688598645179 394 1677248 YPR107C YTH1 SGTC_118 0083-0097 135.343 µM 1.68376843576746 0.0529475797878579 no 244 0.0461132147723706 588 5207356 SGTC_955 1216-0110 33 µM 1.68341737480221 0.0529827958554366 no 245 0.0461471610375803 429 3619719 SGTC_2451 5856223 45.7 µM 1.68114945748252 0.0532107458489143 no 246 0.0463669439553748 315 2179896 SGTC_1199 1638-0010 4.46 µM 1.68032096179934 0.0532942121692696 no 247 0.046447442388743 373 3111136 SGTC_2549 cedrol 20.94 µM 1.67257255136684 0.0540798540808243 no 248 0.04720573711259 270 6708665 A sedative which affects the nervous system. SGTC_1376 2910-0861 41.3 µM 1.67192648146538 0.0541457735311122 no 249 0.0472694100724197 364 1112859 SGTC_2325 6158266 200 µM 1.66838445064368 0.054508302762202 no 250 0.0476197165010778 332 3623240 SGTC_1940 st075990 51.1 µM 1.66618589367048 0.0547342903893832 no 251 0.0478381973593364 382 1084979 SGTC_604 1000-0114 314 µM 1.66559245949605 0.0547954157113186 no 252 0.0478973070224547 359 1572745 SGTC_1877 wortmannin 25 µM 1.66522303193256 0.0548334949906178 no 253 0.0479341337796642 419 312145 A covalent inhibitor of PI 3-kinase. SGTC_2644 guaiazulene 100 µM 1.66116517978067 0.0552531419681165 no 254 0.0483401383626505 297 3515 A coloring agent. SGTC_564 3555-0129 330 µM 1.65647715695694 0.0557411122678067 no 255 0.0488126136465425 246 563260 SGTC_2664 lyso-paf C-16 73.48 µM 1.64307537218789 0.0571548574736299 no 256 0.0501836698303766 365 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2328 6201408 200 µM 1.64117306256507 0.0573577982813756 no 257 0.0503807478655318 340 2890418 SGTC_3328 9140624 29.0385 µM 1.63866093089251 0.0576266639162074 no 258 0.0506419474944078 353 4904392 SGTC_2866 9034245 58.44 µM 1.63276115836921 0.0582619954218524 no 259 0.0512596195485373 298 6462273 SGTC_1666 st014829 29 µM 1.62771630992809 0.0588096151068648 no 260 0.0517925265621483 385 3858230 SGTC_2201 6605497 169.863 µM 1.62202681655814 0.0594320489512345 no 261 0.0523988031909038 313 670741 SGTC_749 1000-0129 128 µM 1.62144749358316 0.0594957158252685 no 262 0.0524608510449473 388 708470 SGTC_106 0092-0003 11.579 µM 1.62099705005234 0.0595452559415035 no 263 0.0525091356790075 270 1072148 SGTC_3126 9127922 49.47 µM 1.60859372750569 0.0609221250625063 no 264 0.053852603344661 378 45595682 SGTC_141 0443-0274 32.331 µM 1.60656691246959 0.0611494653225143 no 265 0.0540747028242114 500 1627241 SGTC_95 0471-0001 561.058 µM 1.60329292119688 0.0615180964845344 no 266 0.0544349993027116 384 4015405 SGTC_2863 9028737 58.44 µM 1.59800690898964 0.0621169291340013 no 267 0.0550207197448837 298 6460917 SGTC_1249 0481-0015 10.2 µM 1.59769758797273 0.0621521113139107 no 268 0.0550551479173523 326 4227577 SGTC_2388 9080168 200 µM 1.59432673339831 0.0625365208690123 no 269 0.0554314365033379 315 15943073 SGTC_443 clozapine 122 µM 1.59070793168568 0.062951266481663 no 270 0.0558376605348495 285 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1922 5578187 25 µM 1.58991305695851 0.0630426523015947 no 271 0.0559272020432899 374 1350412 SGTC_1772 st048439 82.2 µM 1.58585972465754 0.0635102670030961 no 272 0.0563855669128496 402 2927068 YDL195W SEC31 SGTC_52 0329-0193 875 nM 1.58283111185949 0.0638614230155411 no 273 0.0567299817363053 393 3739292 SGTC_2543 pimpinellin 60.67 µM 1.57907353842093 0.0642991960620376 no 274 0.0571595952021107 357 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_595 3909-8003 73.7 µM 1.56573219430618 0.0658723781965087 no 275 0.0587056629851737 380 699517 SGTC_379 3970-0972 5.9 µM 1.5645098815707 0.0660179894826657 no 276 0.0588489370958549 393 2898042 YBL034C STU1 SGTC_2423 st077119 87.2 µM 1.56332515678181 0.0661593608857512 no 277 0.0589880670375644 384 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2802 7925815 54.55 µM 1.54607248397285 0.0682447664623289 no 278 0.0610435316422243 430 1262923 SGTC_1197 1601-0112 267 µM 1.54151686985745 0.068803802560256 no 279 0.0615955201813528 428 7350313 SGTC_836 0330-0104 1.35 µM 1.54065266987088 0.0689102490178066 no 280 0.061700670883908 391 46494820 SGTC_1077 5-fluorocytosine 377 nM 1.53894813573596 0.0691205743747323 no 281 0.0619084792026408 375 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_454 lyso-paf C-16 6.67 µM 1.53536365590917 0.0695644829565064 no 282 0.0623472629626654 387 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_297 0986-0032 24 µM 1.52467003029635 0.0709018479118329 no 283 0.0636707102487996 347 2847425 SGTC_235 0330-0087 5 mM 1.52394454905748 0.0709932884708855 no 284 0.0637612818174095 431 46494818 YHR062C RPP1 SGTC_2993 9054257 71.4286 µM 1.52112048894119 0.0713500992487661 no 285 0.0641148018507474 450 6470217 YGL055W OLE1 SGTC_1767 st044992 70.3 µM 1.51961041392478 0.0715414562740783 no 286 0.0643044595087101 437 9600693 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.51333115426095 0.0723413909438243 no 287 0.0650977814729431 449 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_181 1447-1644 8.07 µM 1.51178923140595 0.0725388655587315 no 288 0.06529374488127 407 534600 SGTC_2146 5545642 200 µM 1.51169137967396 0.0725514113848816 no 289 0.0653061963113935 395 825326 SGTC_233 rapamycin 362 pM 1.51049241047493 0.0727052693338359 no 290 0.0654589122601503 399 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1141 3253-0389 52.6 µM 1.50898692170444 0.0728988151499196 no 291 0.0656510624964603 379 5402031 SGTC_2791 5663188 71.43 µM 1.50444876201015 0.0734846281333957 no 292 0.0662329284404833 407 54690634 SGTC_471 1-acyl-paf 4 µM 1.50133678069506 0.0738884175449839 no 293 0.0666342381670957 407 16759367 SGTC_1327 1436-0082 2.18 µM 1.49154087904092 0.0751705386532999 no 294 0.0679097734699462 409 15992205 SGTC_1452 4194-0072 190 µM 1.4908173846009 0.0752659006161313 no 295 0.0680047231201366 469 1343545 SGTC_2755 lomerizine 42.69 µM 1.49061139936565 0.0752930678660425 no 296 0.0680317748583476 447 3949 A calcium channel blocker. SGTC_2200 6600604 21.907 µM 1.49021167297175 0.0753458088303812 no 297 0.068084294041653 461 2904777 SGTC_1927 st060202 13.8 µM 1.4898788644627 0.0753897419503429 no 298 0.068128044902876 410 688887 SGTC_2255 7941087 197.44 µM 1.48306387498617 0.076293668847042 no 299 0.0690287204061812 483 935561 SGTC_285 1486-1325 46 µM 1.48062883353091 0.0766186402612904 no 300 0.0693527537791737 453 22310230 SGTC_1020 4335-0961 93.3 µM 1.4795911580546 0.0767574439806132 no 301 0.0694911937893112 406 669075 SGTC_3026 9090633 49.47 µM 1.47923342220564 0.0768053404866987 no 302 0.0695389699112196 433 25236842 SGTC_2198 6589944 200 µM 1.47891618490464 0.0768478337341876 no 303 0.0695813585516488 334 5290268 SGTC_2975 9084847 53.72 µM 1.47648876777124 0.0771735728049346 no 304 0.0699063641851669 446 27211724 SGTC_1325 1431-0015 227 µM 1.47559910351218 0.0772932206618032 no 305 0.0700257729744382 392 1103340 SGTC_2529 gangaleoidin 93.61 µM 1.47544681746556 0.0773137152007745 no 306 0.0700462281943532 388 4565183 SGTC_2612 dictamnine 15.46 µM 1.47431454512345 0.0774662250092234 no 307 0.0701984603708321 441 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1419 3993-2473 62.6 µM 1.47120793487981 0.0778858387762295 no 308 0.070617445973767 437 704026 SGTC_2112 5488546 200 µM 1.47103511824189 0.0779092318841848 no 309 0.0706408099026261 443 600757 SGTC_1145 3546-0597 10.2 µM 1.46386582256458 0.0788844001485041 no 310 0.0716153066607928 462 875334 SGTC_1195 1502-0147 41.1 µM 1.45914090226491 0.0795321214616109 no 311 0.0722631652566781 473 817940 SGTC_1696 st025591 34.7925 µM 1.45896372577027 0.079556487965043 no 312 0.0722875459368239 473 2787147 SGTC_2533 agelasine 13.65 µM 1.45585656254323 0.0799847246402169 no 313 0.0727161378428097 482 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3205 9113483 49.47 µM 1.4544632294563 0.08017732221931 no 314 0.0729089604159119 487 17018033 SGTC_344 k064-0035 6.43 µM 1.4541627196263 0.0802189069945079 no 315 0.0729505990659185 431 5088750 SGTC_1524 corynanthine 62.1 µM 1.45295233209188 0.080386566398005 no 316 0.0731184947163307 423 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1871 st057448 67.3 µM 1.45251845940039 0.0804467296170255 no 317 0.0731787501385692 469 691747 SGTC_876 0720-0963 56.8 µM 1.45147242973169 0.0805919178209264 no 318 0.073324176978234 480 765861 SGTC_740 k014-0057 261 µM 1.43891008024588 0.0823510554347286 no 319 0.0750880005691677 514 4012779 SGTC_343 4130-2827 29.8 µM 1.43619717366804 0.0827347189025226 no 320 0.0754731215249247 484 1118244 SGTC_254 nsc-64875 3.808 µM 1.42799446414641 0.0839029404651314 no 321 0.0766467259576639 445 56993 SGTC_2853 9015042 58.44 µM 1.42375517918484 0.0845115297303907 no 322 0.077258677212111 422 6457456 SGTC_2355 9061122 103.12 µM 1.42258617448348 0.0846799324604784 no 323 0.0774280771000396 432 5302957 SGTC_467 ro 31-8220 72.8 µM 1.42176193105057 0.0847988212818602 no 324 0.0775476872725258 503 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1103 duloxetine 36.1 µM 1.41940167086816 0.085139957369355 no 325 0.0778909727906372 524 60835 A selective serotonin reuptake inhibitor. SGTC_524 r073-0010 27.8 µM 1.41558721242045 0.0856934459248156 no 326 0.0784481987405771 450 2772106 SGTC_1045 1348-1485 165 µM 1.41470134792319 0.0858223719285654 no 327 0.078578039508037 540 6810614 SGTC_3059 1327-0034 3 µM 1.41280902554347 0.0860982609447776 no 328 0.0788559418816248 485 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2917 7979103 53.79 µM 1.40274028434224 0.0875773880510385 no 329 0.0803471499396855 543 2980565 SGTC_2310 7668677 200 µM 1.40132805826546 0.0877863553362501 no 330 0.0805579972354191 474 2197143 SGTC_2506 ethyl hematommate 54.16 µM 1.39973509263303 0.0880225128047578 no 331 0.0807963304979845 401 3940691 An allergen. SGTC_1476 4112-3294 3.34 µM 1.39870530706612 0.0881754306114112 no 332 0.0809506860618488 464 704369 SGTC_1285 0929-0069 65.5 µM 1.39615724603695 0.0885546555179133 no 333 0.0813335740956189 485 1206237 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.39410504471759 0.0888609644865791 no 334 0.0816429430175331 462 140250 A respiratory chain inhibitor. SGTC_2943 9068529 45.32 µM 1.39154640823109 0.0892439673416463 no 335 0.0820298985348729 524 3270634 SGTC_3294 9122953 26.2835 µM 1.39137222115086 0.0892700860302518 no 336 0.0820562918787138 482 16459826 SGTC_2309 7664088 163.95 µM 1.38496090348504 0.0902354000916036 no 337 0.0830322112240202 548 704922 SGTC_2029 5175081 200 µM 1.384106332497 0.0903646511513586 no 338 0.0831629491036277 533 1380876 SGTC_2315 7733312 200 µM 1.38140914658212 0.0907734933747384 no 339 0.0835765975769299 449 726316 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.37327527549342 0.0920147438818537 no 340 0.0848333929362037 488 2724278 An inhibitor of dopamine biosynthesis. SGTC_383 2324-0395 7.37 µM 1.37251608767626 0.0921312361473709 no 341 0.0849514171036092 515 3146421 SGTC_84 0443-0269 128.823 µM 1.37212402886505 0.0921914376700921 no 342 0.0850124151695894 501 6150058 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.37191121854804 0.092224127368996 no 343 0.0850455387864082 522 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2010 4012422 159 µM 1.36903640053093 0.0926665680351255 no 344 0.0854939484268998 507 952393 SGTC_1534 6-azauridine 81.6 µM 1.36894172409348 0.0926811655985506 no 345 0.0855087459690708 556 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3320 9137005 35.139 µM 1.3682342521302 0.0927903000856819 no 346 0.0856193816827287 472 4908713 SGTC_1470 k295-0292 231 µM 1.36501225566433 0.0932885266896376 no 347 0.0861245990414171 525 5045612 SGTC_2642 cholecalciferol 100 µM 1.35824791643997 0.0943409414980827 no 348 0.0871925154096991 459 9821465 A vitamin D precursor, similar to steriods. SGTC_1897 st060201 15 µM 1.35736457380826 0.0944790182193808 no 349 0.0873326993965064 466 611878 SGTC_1446 4239-0190 62 µM 1.35688529467396 0.0945539974447503 no 350 0.0874088300205835 550 1340085 SGTC_1994 st072947 40.9 µM 1.35421789055072 0.0949720921576489 no 351 0.0878334364514866 511 5286565 YDL195W SEC31 SGTC_3148 9097893 49.47 µM 1.35412956914098 0.0949859591035413 no 352 0.0878475220200334 486 17174100 SGTC_853 0419-0306 21 µM 1.35367274849565 0.0950577062596832 no 353 0.087920403033075 489 762713 SGTC_2751 anetholtrithion 17.25 µM 1.35352584618318 0.0950807868649203 no 354 0.087943849358012 514 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3006 9075424 71.4286 µM 1.35185868332126 0.095343012992595 no 355 0.0882102634824502 490 7465181 SGTC_485 niflumic acid 177 µM 1.35040165318536 0.0955726232394479 no 356 0.0884435904265436 474 4488 A COX2 inhibitor. SGTC_497 capsazepine 133 µM 1.3474776041083 0.0960346451241321 no 357 0.0889132308300187 498 2733484 A calcium channel blocker. SGTC_2630 antimycin a 100 µM 1.34431045028731 0.0965369299302414 no 358 0.0894240088307701 552 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1981 st071826 47 µM 1.34293252451962 0.0967560592291656 no 359 0.089646911844382 460 11838600 SGTC_1014 4130-3005 69.3 µM 1.34187977453074 0.0969237223410604 no 360 0.0898174903143347 545 743608 SGTC_1073 triclabendazole 3.09 µM 1.34020606453929 0.0971907197817538 no 361 0.0900891802563806 590 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2995 9067767 71.4286 µM 1.33768995144002 0.0975931159756701 no 362 0.0904987639902463 448 11673567 SGTC_33 0986-0033 35.816 µM 1.33679135720193 0.0977371217591259 no 363 0.090645375572778 479 2848082 SGTC_1765 st044815 90.4 µM 1.33484121681735 0.0980501806772178 no 364 0.0909641601779511 520 645695 SGTC_519 k048-0011 62.8 µM 1.332430909185 0.0984381253899457 no 365 0.0913593154366267 521 6836379 SGTC_1275 0867-0008 21.1 µM 1.33233667173108 0.0984533159289874 no 366 0.0913747909019452 519 3422836 SGTC_2461 5755302 26.15 µM 1.33125111112003 0.098628425877304 no 367 0.0915531993984059 562 2788904 SGTC_1292 0kpi-0043 232 µM 1.32975490640291 0.0988701496290513 no 368 0.0917995188808945 511 3333905 SGTC_3063 1327-0034 4 µM 1.32678887554152 0.0993506162869549 no 369 0.0922892657022581 504 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2497 7-hydroxyflavone 100 µM 1.32597830774987 0.0994822164688877 no 370 0.0924234413507098 477 5281894 SGTC_15 0266-0086 27.098 µM 1.31868894857062 0.100671412953415 no 371 0.0936365614680459 635 1712902 YIL048W NEO1 SGTC_708 3448-5400 146 µM 1.31729020787411 0.1009007863083 no 372 0.0938706831224902 574 3462195 SGTC_2517 totarol 10 µM 1.31694827320457 0.100956916588883 no 373 0.0939279819188491 478 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_146 3448-8650 53.125 µM 1.30785750972983 0.102457568036705 no 374 0.095460821843579 707 2891488 YIL048W NEO1 SGTC_202 3594-0513 34.79 µM 1.30505843604849 0.102922872683711 no 375 0.0959364751749289 504 708429 SGTC_438 sphingosine 6.67 µM 1.30452325836685 0.103012012619073 no 376 0.0960276173549175 447 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_16 erodoxin 22.806 µM 1.30084633387672 0.103625962811697 no 377 0.0966555293150476 616 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2940 9060638 45.86 µM 1.29976240876731 0.103807455649536 no 378 0.0968412065488003 551 4027022 SGTC_782 0083-0095 30.5 µM 1.29961118621816 0.103832794728511 no 379 0.0968671318965808 605 3591729 An indicator and reagent. SGTC_32 0928-0142 34.1 µM 1.29715564986826 0.104244876169819 no 380 0.0972888184939223 505 2244242 SGTC_736 0958-0254 92.6 µM 1.29557290213072 0.104511116109222 no 381 0.0975613349658621 598 6812352 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.29552805356351 0.104518667425822 no 382 0.0975690651106118 480 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1725 st036284 20.55 µM 1.2903508512314 0.105393030260677 no 383 0.0984644342703284 615 707914 SGTC_2620 irigenin 100 µM 1.28615253058055 0.106105948144658 no 384 0.0991949170232314 571 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_364 0083-0097 67.7 µM 1.28412939427016 0.10645073871449 no 385 0.0995483423228421 554 5207356 SGTC_2458 5808907 16.39 µM 1.28072067535823 0.107033493923892 no 386 0.100145897489069 579 2731747 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.27976455366695 0.107197365131333 no 387 0.100313976826108 515 2346 DNA damaging agent; causes G2/M arrest. SGTC_2040 5100729 123 µM 1.2745761669202 0.108089765856504 no 388 0.101229648805272 587 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3214 9129694 49.47 µM 1.27347123893094 0.108280501905474 no 389 0.101425436081491 521 17158655 SGTC_1079 idarubicin 2.36 µM 1.27277289018942 0.108401177862692 no 390 0.101549321883712 537 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_46 0329-0187a 2.197 µM 1.27045134287093 0.108803041047111 no 391 0.101961952213913 671 46494817 SGTC_2101 5377231 179.231 µM 1.26944844670299 0.108976974746603 no 392 0.102140583242555 561 2844213 SGTC_1854 st056233 32.9 µM 1.26914601830705 0.109029464532434 no 393 0.102194494983295 549 5393174 SGTC_407 eburnamonine 100 µM 1.26801812612657 0.109225382920159 no 394 0.102395738782602 494 3195 SGTC_938 3126-1755 342 µM 1.2668333737086 0.109431450369789 no 395 0.102607438022621 596 1777771 SGTC_2678 equilin 100 µM 1.26611241542895 0.109556985329796 no 396 0.102736419131984 589 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1180 1193-0155 285 µM 1.26610927256494 0.109557532798989 no 397 0.102736981655478 536 2921347 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.2638590377649 0.109950015392337 no 398 0.103140313227223 581 5711223 A potent inhibitor of glutathione S-transferases. SGTC_653 0203-0016 55.2 µM 1.26241502554006 0.110202408726027 no 399 0.103399742658254 575 295302 SGTC_3091 9116372 49.47 µM 1.26134332682436 0.110389995285167 no 400 0.103592588711848 526 17169793 SGTC_2552 juarezic acid 87.02 µM 1.2569670549444 0.11115837945267 no 401 0.104382782730541 665 1549512 SGTC_336 4111-0029 111 µM 1.25613940097622 0.111304128220594 no 402 0.104532716495581 515 3131175 SGTC_61 0978-8327 98.565 µM 1.25566882708429 0.111387056636859 no 403 0.10461803291249 595 6150059 YHR072W ERG7 SGTC_1723 st034307 2.5525 µM 1.25536734096019 0.111440210248306 no 404 0.104672719727118 562 867466 SGTC_1125 tnp00248 1.32998 µM 1.25424555568755 0.111638146404859 no 405 0.104876383115532 703 24207736 SGTC_3104 9120930 49.47 µM 1.25005634758387 0.112379544727794 no 406 0.105639482194644 510 17014836 SGTC_187 1488-2104 32.728 µM 1.24823677441376 0.112702662900508 no 407 0.105972180207199 609 2852859 SGTC_1354 1498-1681 81 µM 1.24742898646611 0.112846321594963 no 408 0.106120121809409 621 5754243 SGTC_1151 3909-8316 15.3 µM 1.244676412236 0.113336826710372 no 409 0.106625359914289 586 800431 SGTC_1120 ficusin 1.78878 µM 1.2442819335835 0.113407246688382 no 410 0.106697908921168 600 6199 A DNA cross-linker. SGTC_3289 9119912 71.43 µM 1.24346744437715 0.113552743165192 no 411 0.106847815236882 571 17014829 SGTC_2957 9076800 11.52 µM 1.24264637189805 0.113699550309505 no 412 0.106999086947928 525 16459615 SGTC_788 1182-0090 188 µM 1.23864586830779 0.11441677284143 no 413 0.107738336799856 721 5715185 SGTC_2071 5230951 39.92 µM 1.23774013810147 0.114579601118839 no 414 0.107906215551865 623 1799272 SGTC_1190 1486-1332 13 µM 1.23725067249292 0.114667663751404 no 415 0.107997017272413 575 4150046 SGTC_2775 cyproheptadine 69.59 µM 1.23569172268996 0.11494846452173 no 416 0.108286587740196 602 2913 A selective serotonin reuptake inhibitor. SGTC_1739 st037196 92.5 µM 1.23422789379241 0.115212576849754 no 417 0.108558998061587 635 612214 SGTC_1003 4049-0218 100 µM 1.22858642711663 0.116234476615193 no 418 0.109613453471723 623 295161 SGTC_1362 1611-0397 101 µM 1.22540597816078 0.116813412781256 no 419 0.110211147811696 598 27816 SGTC_1825 st052143 62.6 µM 1.22406365614835 0.117058367658326 no 420 0.110464107478571 555 674173 SGTC_872 0588-0139 234 µM 1.22312550122279 0.117229783671155 no 421 0.110641149079729 612 2047100 SGTC_1560 lithocholic acid 53.1 µM 1.22089784458693 0.117637524576509 no 422 0.111062350343406 515 9903 A bile acid which acts as a detergent. SGTC_2748 diazoxide 86.69 µM 1.22074790522298 0.117665004859968 no 423 0.111090741797661 546 3019 A potassium channel activatior. SGTC_1040 k898-0338 155 µM 1.21489222281936 0.118741766403201 no 424 0.112203600201187 664 20969351 SGTC_1433 4060-0023 7.6 µM 1.2138531596934 0.118933557516078 no 425 0.11240190112957 624 3840627 SGTC_790 1575-0012 79.1 µM 1.21225169985804 0.119229584513159 no 426 0.112708023310958 622 378741 YLR208W SEC13 SGTC_1665 st014639 11.4 µM 1.21036068344303 0.119579804667202 no 427 0.113070260762641 661 981133 YIL048W NEO1 SGTC_892 0929-0076 29 µM 1.2062338546821 0.120346620043779 no 428 0.113863666853136 660 5751038 SGTC_2173 5763948 167 µM 1.20397251103858 0.120768271395302 no 429 0.114300101730162 629 2867177 SGTC_541 4513-1321 94 µM 1.20328984965375 0.120895764899618 no 430 0.114432087805447 605 747515 SGTC_3114 9122766 49.47 µM 1.20155708935379 0.121219799587117 no 431 0.11476758761462 577 17176985 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.19692243437948 0.122089503145487 no 432 0.115668394491701 613 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2156 5649887 115 µM 1.19528615243697 0.122397599200139 no 433 0.115987624098148 713 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3071 9117417 49.47 µM 1.19323410827902 0.122784749942426 no 434 0.116388850009099 525 45595590 YGL055W OLE1 SGTC_1916 st067606 49.2 µM 1.19241420475545 0.122939677646737 no 435 0.116549436619165 671 19590279 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.18798775109902 0.123778460786217 no 436 0.117419117757129 639 3256 An antibiotic and ribosome inhibitor. SGTC_893 0958-0369 48.9 µM 1.18725582564859 0.1239175408103 no 437 0.117563363354621 667 6819948 SGTC_244 nsc-207895 1.295 µM 1.18619540260659 0.124119235708603 no 438 0.117772570700984 510 42640 SGTC_340 k038-0059 454 µM 1.18416623952541 0.124505827194749 no 439 0.118173631670189 639 23733424 SGTC_2175 5807670 165.306 µM 1.1808497980285 0.125139478859018 no 440 0.11883119869051 620 241186 SGTC_100 0086-0128 49.5915 µM 1.17840880503764 0.125607300570275 no 441 0.119316834567334 689 93297 SGTC_2188 6126565 140.678 µM 1.17566088927233 0.126135403214038 no 442 0.119865206667887 592 874518 SGTC_129 0088-0017 176.636 µM 1.17529734404538 0.126205386178797 no 443 0.119937888365606 611 182446 SGTC_2174 5790901 200 µM 1.17495828225957 0.12627068043344 no 444 0.120005703211012 623 786020 SGTC_264 promethazine 12.5 mM 1.17394478489753 0.126465993333975 no 445 0.120208571235864 766 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1832 st054113 55 µM 1.17358550505894 0.126535281301148 no 446 0.120280544933421 609 1251267 SGTC_1324 1418-0026 34.4 µM 1.17001997815591 0.127224335120552 no 447 0.120996464592471 672 1372513 SGTC_1867 st057372 64 µM 1.16996370354276 0.127235231323328 no 448 0.121007787914844 634 688837 SGTC_2884 9058502 51.95 µM 1.16724601794407 0.12776221759023 no 449 0.121555515925761 656 6471554 SGTC_967 1306-0166 352 µM 1.16658092957561 0.12789141556705 no 450 0.121689824220256 640 4437607 SGTC_1726 st035556 14.5795 µM 1.163696729041 0.128452741641788 no 451 0.122273467733797 702 5919439 SGTC_896 0964-0007 44.5 µM 1.16346406110257 0.128498098145244 no 452 0.12232063565754 670 6756758 SGTC_316 k060-0003 58.6 µM 1.1632873506096 0.128532553679075 no 453 0.122356468064679 633 6152314 SGTC_3044 9093193 49.47 µM 1.15898947144857 0.129372541864879 no 454 0.123230238334284 650 25236277 SGTC_2038 4100038 30.985 µM 1.15571620168767 0.130014824454571 no 455 0.123898629457084 675 3596803 SGTC_1126 isoteolin 1.0172 µM 1.15204865359387 0.130737090536827 no 456 0.124650540443327 650 133323 SGTC_1117 retinoic acid 1.10837 µM 1.15190057547421 0.130766310339182 no 457 0.124680965870558 727 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2707 st078556 66.6 µM 1.14868493128043 0.131401957141272 no 458 0.125342960792229 651 17250899 SGTC_3107 9121808 49.47 µM 1.14750447248602 0.131635836681108 no 459 0.125586592871077 583 662681 SGTC_104 0074-0074 590.992 µM 1.14683243291796 0.131769113425979 no 460 0.125725441031241 525 3943124 SGTC_622 1348-1566 26.3 µM 1.14649210147685 0.131836642372817 no 461 0.125795796763367 725 7340407 SGTC_3292 9120825 59.784 µM 1.14364898534253 0.132401709490436 no 462 0.126384618955381 675 24824900 SGTC_3151 9099821 49.47 µM 1.1426128072402 0.132608063479727 no 463 0.126599692853011 644 17174189 SGTC_2699 st077704 54.6 µM 1.13844095268603 0.133441125910314 no 464 0.127468200904415 662 645852 SGTC_1520 flindersine 88 µM 1.1360449866828 0.133921191625329 no 465 0.127968868561111 690 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2973 9094665 17.96 µM 1.13524275364915 0.134082195281808 no 466 0.128136810296475 751 25237061 YIL048W NEO1 SGTC_2204 7233102 200 µM 1.1331794092425 0.134496907583657 no 467 0.128569459641282 600 2172480 SGTC_37 0566-0070 1.56 µM 1.12810531522748 0.135520493887772 no 468 0.129637722336443 726 1626686 SGTC_3234 9132280 49.47 µM 1.1270053929544 0.135743080990113 no 469 0.129870100425103 689 17612295 SGTC_3115 9123671 49.47 µM 1.12642928403866 0.135859765837057 no 470 0.129991928669835 704 3286988 SGTC_849 0386-0493 241 µM 1.12613303684772 0.135919794345708 no 471 0.130054606077095 654 726119 SGTC_2202 7226349 200 µM 1.11846897267874 0.13747907600435 no 472 0.131683375448501 657 844334 SGTC_1177 0983-0204 23.6 µM 1.11666533952545 0.137847799940166 no 473 0.132068721457155 746 766818 SGTC_2196 6573537 42.6665 µM 1.11591998219444 0.138000373162769 no 474 0.13222819380867 679 2903087 SGTC_913 3487-1245 167 µM 1.11424802149994 0.138343039163124 no 475 0.132586399584775 672 4016153 SGTC_2843 9000894 45.46 µM 1.11079003486252 0.139053587568307 no 476 0.133329368415433 550 2242070 SGTC_2741 miltefosine 3.04 µM 1.11076812637521 0.139058097237799 no 477 0.133334084696097 599 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_757 1066-0008 322 µM 1.10643867878653 0.139951230130394 no 478 0.134268345963556 746 6842497 SGTC_1307 1187-1599 12.2 µM 1.10065735006162 0.1411499417166 no 479 0.135522907576968 707 1538471 SGTC_286 k060-0067 22.9 µM 1.10059185690053 0.141163560951589 no 480 0.135537165602368 681 5985051 SGTC_906 1165-0455 526 µM 1.09979154544926 0.141330056856268 no 481 0.135711478430661 687 3252859 SGTC_989 1501-0895 10.3 µM 1.09781797717333 0.141741204466395 no 482 0.136141989931929 711 2830112 SGTC_2640 pentamidine 10.38 µM 1.09554126120341 0.142216511326455 no 483 0.13663978960668 772 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_348 k064-0012 10.7 µM 1.09428164353709 0.142479942890514 no 484 0.136915736781038 670 5066323 SGTC_1615 st002656 86.5 µM 1.09152864591874 0.143056842467553 no 485 0.137520167068368 719 1584458 SGTC_1047 2043-3044 82 µM 1.09001102931238 0.143375537817333 no 486 0.137854142832129 736 669592 SGTC_1762 st045503 25.4615 µM 1.08900440305333 0.14358719083669 no 487 0.138075972011582 715 4645554 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.08637214608149 0.144141644935456 no 488 0.138657189807031 798 688761 SGTC_2292 7671323 168.05 µM 1.07999702560258 0.145490464556614 no 489 0.140071752349826 718 937504 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.07919159332361 0.145661476342147 no 490 0.140251163241696 690 688803 SGTC_2384 9036245 200 µM 1.07862056078549 0.145782801513441 no 491 0.140378455857795 749 6462766 SGTC_952 1185-0122 232 µM 1.07796291398523 0.145922613434536 no 492 0.140525153401854 713 678600 SGTC_3299 9121982 43.1275 µM 1.07685573105076 0.146158197625226 no 493 0.140772361435197 731 17594604 YPL160W CDC60 SGTC_2053 5265679 138 µM 1.0741338786553 0.146738433434345 no 494 0.141381341134558 735 764595 SGTC_2769 toremifene 3.73 µM 1.07335422972169 0.146904920868762 no 495 0.141556106107054 695 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2784 7567673 72.73 µM 1.07332056436668 0.146912112672916 no 496 0.141563655779292 759 3471247 SGTC_2387 9077560 195.08 µM 1.07064793462228 0.147483810163557 no 497 0.142163880779504 727 5303272 SGTC_1164 k060-0068 93.7 µM 1.06859757095492 0.14792340888628 no 498 0.142625521778474 777 5963676 SGTC_2887 9044784 58.44 µM 1.06824872818214 0.147998288127772 no 499 0.142704164789758 805 6465546 SGTC_2301 7769476 200 µM 1.06701335386106 0.148263665703984 no 500 0.14298290292367 683 977820 SGTC_2648 atorvastatin 78.68 µM 1.06519952417948 0.148653880969113 no 501 0.143392824453633 725 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2172 5754775 163.918 µM 1.06493244328064 0.148711396915268 no 502 0.143453251107498 661 2263357 SGTC_2432 5630864 12.22 µM 1.06355124135163 0.149009076482347 no 503 0.143766020292378 717 5714970 SGTC_1558 st069300 45.6 µM 1.06317917321714 0.149089333407356 no 504 0.143850352654211 671 24208000 SGTC_1720 st037298 9.481 µM 1.06284947592158 0.149160474857933 no 505 0.143925109193278 706 597396 SGTC_2090 5301565 104.445 µM 1.06114328444535 0.149528995781433 no 506 0.144312394746761 810 2056344 SGTC_1191 1487-1166 10.6 µM 1.05999976455942 0.149776324874518 no 507 0.1445723532195 827 3955771 SGTC_1681 tripelennamine 100 µM 1.05949258599541 0.149886108582811 no 508 0.144687751981825 668 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2260 7964312 200 µM 1.05816411610085 0.150173923078715 no 509 0.144990313868601 692 231951 SGTC_1175 0741-0056 27.6 µM 1.05781307109767 0.150250038866302 no 510 0.145070336218128 808 765927 SGTC_7 0192-1582 4.227 µM 1.05709309768045 0.150406228464728 no 511 0.145234550512407 844 252616 SGTC_2879 9041815 71.43 µM 1.05597437816212 0.150649135809685 no 512 0.145489960417679 642 4942971 SGTC_961 1252-1571 372 µM 1.05594883360862 0.150654685342515 no 513 0.145495795907071 758 6813498 SGTC_2065 5221596 34.26 µM 1.05506588904099 0.150846587987361 no 514 0.145697595682869 723 788581 SGTC_2919 7978188 46.38 µM 1.05491931540716 0.150878460619267 no 515 0.145731113752778 765 2980291 SGTC_890 0929-0006 47.2 µM 1.05319998430861 0.15125266614403 no 516 0.146124672836463 714 1378169 SGTC_1622 st003707 19.4 µM 1.05194958374434 0.151525198237461 no 517 0.146411340582614 785 10140899 SGTC_2485 5633444 17.78 µM 1.05112271390307 0.151705598556683 no 518 0.146601116620647 723 5724239 SGTC_2424 5537928 59.2 µM 1.0487022239841 0.15223450325809 no 519 0.147157595178753 780 5382802 SGTC_891 0929-0073 133 µM 1.0448385349015 0.153081297335657 no 520 0.148048800767 764 5603632 SGTC_908 3448-7491 47.7 µM 1.04419715684401 0.153222167970608 no 521 0.148197091058172 814 1203031 SGTC_1683 st010134 710 nM 1.04055864022213 0.154022947952574 no 522 0.149040217577496 746 3818134 SGTC_3329 9141233 27.5565 µM 1.03920194750136 0.154322242022627 no 523 0.149355412470147 748 4909101 YNL103W MET4 SGTC_630 4356-0227 183 µM 1.03708193864717 0.154790697429284 no 524 0.149848835894589 727 779312 SGTC_3086 9117350 49.47 µM 1.0357000441715 0.155096557970413 no 525 0.150171050878391 714 2679265 SGTC_11 0438-0307 1.3 µM 1.03555398460893 0.155128909251394 no 526 0.150205134409595 756 4011476 SGTC_1947 st076332 61.6 µM 1.03552227306583 0.155135933748754 no 527 0.15021253509493 722 24208416 SGTC_190 3970-0790 3.722 µM 1.02839264028704 0.156720566469287 no 528 0.151882584546243 746 2832352 SGTC_1559 coumarin 343 70.1 µM 1.02700702845849 0.157029764717428 no 529 0.152208577273161 734 108770 A hepatotoxic, DNA x-linker. SGTC_2268 7933382 153.85 µM 1.02647211981708 0.157149236461097 no 530 0.15233454936127 845 935025 YOR257W CDC31 SGTC_2537 larixol 68.93 µM 1.02250320299437 0.158037559991923 no 531 0.153271398730706 836 6708759 SGTC_2636 apigenin dimethyl ether 100 µM 1.02146703304424 0.158270017290598 no 532 0.153516610237693 768 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.02021765492198 0.158550604521489 no 533 0.153812623165445 743 689007 SGTC_2880 9042983 58.44 µM 1.01857139553539 0.158920821774029 no 534 0.154203244964886 769 6464714 SGTC_990 3985-0011 41.3 µM 1.01700341966949 0.159273960644528 no 535 0.154575901312942 726 5399565 YGL099W LSG1 SGTC_2591 skatole 100 µM 1.01153501232011 0.160509571334106 no 536 0.155880216176832 770 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_963 1269-2853 151 µM 1.01100993002335 0.160628544632278 no 537 0.156005838562453 741 3668223 SGTC_735 3076-0345 636 µM 1.01080252140057 0.16067555520269 no 538 0.156055478050095 835 2888990 SGTC_3230 9131665 49.47 µM 1.00971702189831 0.160921737578658 no 539 0.156315442423296 674 15943720 SGTC_1225 1216-0074 20.6 µM 1.00847830058477 0.161202970044544 no 540 0.156612449911351 796 4241466 SGTC_2044 5102272 200 µM 1.0036336217637 0.162305956672492 no 541 0.157777621231951 729 592666 SGTC_632 0781-2353 4.65 µM 1.00180055380069 0.162724568803738 no 542 0.158219964857373 810 6811515 YHR007C ERG11 SGTC_2961 9083290 32.55 µM 0.9988731989561 0.163394534775315 no 543 0.158928060409172 761 17741490 SGTC_2072 5231554 129 µM 0.998550300646028 0.163468544119494 no 544 0.159006293000635 856 789545 SGTC_1760 st045453 10.4495 µM 0.996291781910812 0.163986812575602 no 545 0.159554197800724 846 3323419 YIL048W NEO1 SGTC_2799 7812892 81.82 µM 0.993681544515197 0.16458711742101 no 546 0.160188965234842 845 20205235 SGTC_1087 pterostilbene 9.05 µM 0.991125312313879 0.16517638049305 no 547 0.160812197232441 823 5281727 Similar to reservatol, lowers cholesterol. SGTC_910 3454-3003 490 µM 0.989587647701642 0.165531500143243 no 548 0.161187855003278 832 820824 SGTC_652 0437-0092 114 µM 0.988415791407948 0.165802468641895 no 549 0.161474528409741 790 3091274 SGTC_1638 st008370 60.6 µM 0.988244158029603 0.165842179513222 no 550 0.161516543299685 792 24207134 SGTC_646 4092-0839 27.3 µM 0.987115504977728 0.166103469468768 no 551 0.161793008775558 848 877796 SGTC_3019 9081971 49.47 µM 0.984220324279358 0.166774936614705 no 552 0.162503597377457 867 16451803 SGTC_2709 st078560 56 µM 0.983558431305747 0.166928692299035 no 553 0.162666336132283 834 17250903 SGTC_2362 9071156 126 µM 0.982234901587086 0.167236418253053 no 554 0.162992068475767 815 653133 SGTC_824 1304-0008 100 µM 0.981552134732588 0.167395307159166 no 555 0.163160269102195 823 768245 SGTC_576 1073-0113 22.7 µM 0.98113557947153 0.167492292857284 no 556 0.163262943491914 1019 5439563 SGTC_1457 k015-0032 57.3 µM 0.976333438330401 0.168612978923986 no 557 0.164449627294447 821 4302660 SGTC_2327 6189656 200 µM 0.976168166109477 0.168651634464708 no 558 0.164490567908974 826 5349088 SGTC_2825 7998094 58.44 µM 0.974047127367291 0.169148230048328 no 559 0.165016570015017 781 2987815 SGTC_2937 9044753 11.33 µM 0.970315488143124 0.170024189622267 no 560 0.165944629725374 869 6465530 YGL099W LSG1 SGTC_26 0302-0163 425.158 µM 0.97010930891579 0.170072672450105 no 561 0.165996004703327 844 3100915 SGTC_1712 st032288 53.4 µM 0.96972542997236 0.170162964782653 no 562 0.16609168561955 928 2883011 SGTC_97 0535-0701 19.132 µM 0.969491624205919 0.170217973387194 no 563 0.166149978608704 782 2832013 YGL099W LSG1 SGTC_2361 9034121 116 µM 0.967818376542236 0.170611978883045 no 564 0.166567542234763 800 6496917 SGTC_1626 st003712 1.76 µM 0.967661513553255 0.170648945871834 no 565 0.166606722528469 769 24207035 SGTC_1255 0566-0045 221 µM 0.967031492339787 0.170797470957864 no 566 0.166764145351921 836 2788469 SGTC_2576 guaiol 23.12 µM 0.964615497214138 0.171367799166795 no 567 0.167368717177069 897 227829 SGTC_3183 9108214 49.47 µM 0.962607667760221 0.171842699504625 no 568 0.167872224047665 758 4974831 SGTC_2654 protoveratrine a 100 µM 0.96170325117682 0.172056890235202 no 569 0.168099344380305 836 5702278 A heart drug and vasodilator. SGTC_2834 9001755 58.44 µM 0.960823525641608 0.172265396873896 no 570 0.168320453819831 761 2989575 SGTC_2245 6637752 200 µM 0.960642779323289 0.17230825610916 no 571 0.168365905594362 759 681890 SGTC_9 0092-0002 10.449 µM 0.959471098925035 0.172586254268515 no 572 0.168660736218018 842 759368 SGTC_924 2046-0044 21.3 µM 0.956122614422603 0.173382306244354 no 573 0.169505145369692 868 3623589 SGTC_2646 retinol 96.75 µM 0.955676326486507 0.17348858076061 no 574 0.169617893219483 828 445354 A vitamin A analog and teratogen. SGTC_1043 0916-0009 19.3 µM 0.954725011188941 0.173715255753833 no 575 0.169858389074706 958 3101130 SGTC_838 0109-0203 71.4 µM 0.954162889371276 0.173849284046517 no 576 0.170000598162282 853 759422 SGTC_2839 9003951 25.97 µM 0.953389149867405 0.174033876474642 no 577 0.170196468397622 823 2990634 SGTC_2845 9003024 42.97 µM 0.951687522722273 0.174440274894039 no 578 0.170627739556423 870 2990173 SGTC_2736 butenafine 14.65 µM 0.951560980464464 0.174470520955303 no 579 0.170659839151474 872 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2663 amphotericin b 100 µM 0.950833219449067 0.174644534656461 no 580 0.170844523145097 822 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_378 3970-0959 8.33 µM 0.948043817093335 0.175312524110382 no 581 0.171553574053673 848 6615653 SGTC_3264 9137442 49.47 µM 0.947943912766701 0.175336478614856 no 582 0.171579004020556 818 17015726 SGTC_761 k216-0224 480 µM 0.947069927188833 0.175546126504155 no 583 0.171801573797361 930 1340404 SGTC_720 r052-1644 49.9 µM 0.945690337323718 0.175877379730544 no 584 0.172153276180651 767 1422863 YOR257W CDC31 SGTC_1086 cerivastatin 2.18 µM 0.94492449954881 0.176061435747558 no 585 0.172348711362093 846 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1075 aripiprazole 15.2 µM 0.944287807642427 0.176214546558805 no 586 0.172511297338493 911 60795 An atypical antipschotic. YIL048W NEO1 SGTC_981 1488-1094 54.9 µM 0.938981675286078 0.177493833977901 no 587 0.173870076390636 807 3449522 SGTC_2776 terbinafine 19.92 µM 0.938220143772511 0.177677916073803 no 588 0.174065644202934 844 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1008 4106-0037 6 µM 0.936979501166052 0.177978069737536 no 589 0.174384551195485 872 2905394 SGTC_3229 9132204 49.47 µM 0.936679575922565 0.17805067982349 no 590 0.174461702611247 874 17682924 SGTC_1101 ebselen 5.29 µM 0.936511773592976 0.17809131189826 no 591 0.174504876781894 941 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1183 1254-0324 198 µM 0.935427954916324 0.178353891248365 no 592 0.17478389792561 868 5799357 SGTC_3020 9089140 49.47 µM 0.934791919618512 0.178508098566965 no 593 0.174947772317096 865 17217859 SGTC_2307 7538926 6.34 µM 0.932000978793254 0.179185756985981 no 594 0.17566800979686 873 96582 SGTC_2898 9056270 58.44 µM 0.929817898141609 0.179716949342878 no 595 0.176232688865797 821 19154699 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.92842139716974 0.180057267596791 no 596 0.176594511769986 884 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_148 3253-0744 288.01 µM 0.928330031991483 0.180079546792311 no 597 0.17661820016241 868 6893655 SGTC_2840 9008771 71.43 µM 0.927837216193065 0.180199748670863 no 598 0.176746007931221 837 2992978 SGTC_1016 4226-1401 38 µM 0.927138604566918 0.18037023213827 no 599 0.17692728733826 864 2901613 SGTC_2645 abamectin 100 µM 0.926495224350121 0.180527326867232 no 600 0.177094338902778 860 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1022 4477-0945 21.3 µM 0.923698667689131 0.181211161405924 no 601 0.177821612988326 883 4648966 SGTC_1715 st032160 10.2275 µM 0.923463273549085 0.181268795641618 no 602 0.177882915564193 850 5289825 SGTC_2350 9023895 38.85 µM 0.922933926716325 0.181398443599449 no 603 0.178020819523102 870 2997209 SGTC_501 nsc-95397 161 µM 0.919719354873643 0.182187004752812 no 604 0.178859717807754 857 262093 SGTC_405 ebelactone b 50 µM 0.919318550913026 0.182285475300216 no 605 0.178964488737438 879 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1286 0929-0070 131 µM 0.918817311731785 0.182408667825585 no 606 0.179095567964721 912 1420408 SGTC_599 1935-0052 86.5 µM 0.914986509014652 0.183351903964392 no 607 0.180099356303126 922 9557311 SGTC_1506 4226-2149 212 µM 0.914900102805975 0.183373214270294 no 608 0.180122038047156 946 991114 SGTC_205 1486-1330 71.903 µM 0.914724298983364 0.183416577417387 no 609 0.180168192318688 864 4118834 SGTC_2191 5911152 200 µM 0.913224627328051 0.183786740914761 no 610 0.180562207034504 910 2875902 SGTC_3215 9129942 49.47 µM 0.911652498643771 0.18417528819759 no 611 0.180975838424052 849 17682944 SGTC_951 1171-0579 82.7 µM 0.911364505035498 0.184246520394004 no 612 0.181051674633678 942 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1802 st050112 57.9 µM 0.910502120148905 0.184459924761928 no 613 0.181278882063207 924 4662563 SGTC_2289 7946404 165.07 µM 0.907499990861116 0.185204025373998 no 614 0.182071227156357 937 1246120 YPR165W RHO1 SGTC_394 menadione 8.33 µM 0.906650039338635 0.185415030465405 no 615 0.182295945595151 907 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1923 st058458 19.1 µM 0.906354650325745 0.185488397325908 no 616 0.182374083977774 966 3534982 SGTC_2114 5491910 81.25 µM 0.906317013924525 0.185497746511905 no 617 0.182384041326521 899 2849228 SGTC_854 0422-0053 192 µM 0.905101863461749 0.185799756844427 no 618 0.18270571250787 928 3596728 SGTC_611 3453-1652 23.7 µM 0.905064022562504 0.185809166616998 no 619 0.182715735327018 951 1560575 SGTC_1485 3909-9022 254 µM 0.904970285546673 0.185832477166882 no 620 0.182740564681449 966 714516 SGTC_520 3584-0023 682 µM 0.902975495177338 0.186328972165938 no 621 0.183269450301345 834 1340790 SGTC_698 k064-0052 127 µM 0.902649804205015 0.186410113265245 no 622 0.18335589242678 918 5088751 SGTC_86 0417-1630 471.922 µM 0.901089457501266 0.186799154165524 no 623 0.183770378905721 1003 3634867 SGTC_2561 acetosyringone 100 µM 0.900323014575512 0.186990435122316 no 624 0.183974188426308 1005 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1057 3448-5381 134 µM 0.89995360025109 0.187082673020454 no 625 0.184072471893332 933 5497911 SGTC_1462 k081-0014 26.5 µM 0.89716573958107 0.187779672447436 no 626 0.184815241907469 742 3270634 SGTC_2404 5161160 200 µM 0.897131042425227 0.187788357255174 no 627 0.184824497996128 940 2831543 SGTC_1176 0848-0131 83.3 µM 0.896955169814071 0.187832382540966 no 628 0.184871419601212 982 6769040 SGTC_2414 st077232 92.9 µM 0.896567689012376 0.18792940110534 no 629 0.184974822938646 839 729801 SGTC_3179 9107801 49.47 µM 0.896200997930759 0.188021242768679 no 630 0.185072711409121 913 4818259 SGTC_3246 9135460 32.98 µM 0.895142513053008 0.188286506894947 no 631 0.185355455245169 850 41446951 SGTC_195 4234-0266 16.654 µM 0.893245914750884 0.188762385579821 no 632 0.1858627473513 949 2303354 SGTC_1052 3253-3998 198 µM 0.892116166466482 0.189046204599707 no 633 0.186165335266979 970 5450317 SGTC_1847 st056231 15 µM 0.891101226448814 0.189301405127508 no 634 0.186437433517992 986 5393180 SGTC_1805 st050013 60.3 µM 0.88999066041743 0.189580893101665 no 635 0.186735450514456 900 4037144 SGTC_172 1112-0046 2.638 µM 0.888453259673399 0.189968218149529 no 636 0.187148493653311 835 2802135 YIL048W NEO1 SGTC_2932 9016711 44.54 µM 0.88834945544191 0.189994387587096 no 637 0.187176402388146 976 7117328 SGTC_274 sirtinol 40.1 µM 0.887196166402086 0.190285285149186 no 638 0.187486648020767 914 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_283 0987-0079 11.7 µM 0.886085368364038 0.190565723589749 no 639 0.18778576344101 963 411556 SGTC_2427 5545055 42.75 µM 0.884951565628403 0.19085223144966 no 640 0.188091377326242 969 5372858 SGTC_1807 st050092 58.9 µM 0.884165426473633 0.19105104104071 no 641 0.188303459415494 889 5008496 SGTC_3225 9130819 49.47 µM 0.882935480221665 0.191362341308015 no 642 0.188635566181305 938 4547121 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.882529906723993 0.1914650603628 no 643 0.188745157161137 969 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_143 4032-1194 15.74 µM 0.879970452150114 0.192114068990379 no 644 0.189437658328743 993 1806963 SGTC_1491 4138-0063 26.5 µM 0.87988222406149 0.192136465226431 no 645 0.189461557688351 925 23883227 SGTC_214 4373-3496 70 µM 0.879339419139111 0.192274288541934 no 646 0.189608634335739 1083 3779166 SGTC_1042 0350-0096 82 µM 0.87779190487603 0.192667548899496 no 647 0.190028329166676 908 3122515 SGTC_675 1309-0189 238 µM 0.877782078169013 0.192670047670096 no 648 0.190030996049611 892 4246530 SGTC_1370 2001-0092 44.6 µM 0.87487064886952 0.193411248359026 no 649 0.190822145465557 1043 790957 SGTC_3033 9090887 49.47 µM 0.873380868334264 0.19379119323052 no 650 0.191227757701921 963 19325384 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.872660209945891 0.193975148878734 no 651 0.191424155906306 1017 5024745 SGTC_2779 methotrexate 400 µM 0.871537223843746 0.194262014921797 no 652 0.191730445165589 1020 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1652 st011932 78 µM 0.871180822670568 0.194353111340972 no 653 0.191827714636663 928 1551076 SGTC_2323 6148992 148.28 µM 0.867221123797733 0.195366962290622 no 654 0.192910432176503 846 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_355 1311-2252 105 µM 0.867005202677676 0.195422339479732 no 655 0.192969579539242 906 5338538 SGTC_2359 9039622 200 µM 0.866869447499576 0.195457161428261 no 656 0.193006772681868 990 6463596 SGTC_673 1082-0474 110 µM 0.863210535112386 0.196397111562016 no 657 0.194010861191504 1051 3098046 SGTC_703 3875-0075 71.8 µM 0.862402709464661 0.196605005189331 no 658 0.194232975039411 1011 2850814 SGTC_1654 st012436 41.8 µM 0.860847934297656 0.197005501029858 no 659 0.194660900306281 920 4323132 SGTC_1931 st074438 57.1 µM 0.860276538871409 0.197152811257634 no 660 0.194818311156405 975 2787313 SGTC_1633 st005664 67.9 µM 0.857953774308039 0.19775232404152 no 661 0.195458994517971 994 2063822 SGTC_166 k072-0058 166.424 µM 0.857250927419707 0.197933947893359 no 662 0.195653111239557 1017 5846229 SGTC_1973 st070275 50.2 µM 0.857198380478244 0.197947530684188 no 663 0.195667628688572 950 17118334 SGTC_527 4476-4215 268 µM 0.856811533418635 0.198047543607383 no 664 0.195774525301938 938 4418754 SGTC_3008 9078912 71.4286 µM 0.85669542720763 0.198077566904813 no 665 0.195806615595011 942 16648731 SGTC_3176 9106582 49.47 µM 0.855865612045524 0.198292224467232 no 666 0.196036058971777 865 17018027 SGTC_1808 st050063 61.5 µM 0.855759467924113 0.198319692077958 no 667 0.196065419515462 958 4011993 SGTC_3028 9087778 49.47 µM 0.854269462182469 0.198705512951751 no 668 0.196477851714615 985 17217395 SGTC_3270 9137563 49.47 µM 0.853680496370382 0.19885814400469 no 669 0.196641021774358 921 17015724 SGTC_1342 1486-1464 234 µM 0.85282496098441 0.199079982663071 no 670 0.196878189787075 965 3253938 SGTC_323 4013-0906 34.3 µM 0.851123496444817 0.199521611989446 no 671 0.19735037723566 995 2910086 SGTC_1000 4048-0884 8.67 µM 0.850296643048014 0.199736441429498 no 672 0.197580091235396 927 13040088 SGTC_1684 st024538 14.6195 µM 0.850042559150319 0.199802484339102 no 673 0.197650712536129 960 6732859 SGTC_3333 9141820 12.094 µM 0.8499348178298 0.199830493031858 no 674 0.197680663282808 924 1939433 SGTC_713 1488-1073 324 µM 0.848506103364153 0.200202128325638 no 675 0.198078087430153 986 3312542 SGTC_2121 5257820 149.641 µM 0.847402008767285 0.200489608251073 no 676 0.198385542610194 1034 791256 SGTC_289 k017-0060 526 µM 0.845839930860195 0.200896759363998 no 677 0.198821023149917 990 5512909 SGTC_807 1315-0151 48 µM 0.845472899073894 0.200992497074736 no 678 0.198923428866248 1044 4011080 SGTC_1358 1509-0022 2.48 µM 0.843789833917009 0.20143186341372 no 679 0.199393428665933 999 3258434 SGTC_850 0388-0143 75.9 µM 0.842722396245766 0.201710817451335 no 680 0.199691859254319 942 67273 SGTC_654 1124-0271 80.9 µM 0.841972914165528 0.201906818176147 no 681 0.199901557397282 978 5403748 SGTC_2344 7990960 76.95 µM 0.841241566347439 0.202098186389527 no 682 0.200106309346933 923 140813 SGTC_2903 5923464 63.88 µM 0.840044843878148 0.202411560922588 no 683 0.200441621793539 1005 2876576 SGTC_583 1488-1091 88.9 µM 0.839354513180818 0.202592463449155 no 684 0.200635200550068 1129 4303273 SGTC_212 3807-4682 38.772 µM 0.838109928986758 0.202918853271989 no 685 0.200984483504274 1117 3125501 YBL034C STU1 SGTC_546 peri-Naphthalide 147 µM 0.83796185318893 0.202957706762079 no 686 0.2010260641029 981 223824 A penicillin ester. SGTC_2013 4024628 200 µM 0.837827524709268 0.202992956947505 no 687 0.201063788833096 936 5230760 SGTC_1801 st050089 28.441 µM 0.837299416891882 0.203131577282651 no 688 0.201212143475817 1031 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1722 st034304 3.6505 µM 0.837011097976826 0.203207280490724 no 689 0.201293164948522 980 4036148 YLR033W RSC58 SGTC_2949 9072542 2.23 µM 0.833665739329538 0.204086893971466 no 690 0.20223468474534 1016 16457352 SGTC_2706 st078239 82.5 µM 0.833226481862227 0.204202558566428 no 691 0.202358505003342 1025 15434492 SGTC_1837 st055472 66.5 µM 0.831101974346555 0.20476253136625 no 692 0.202958012245583 1006 676091 SGTC_1732 st034308 51.822 µM 0.83078552985714 0.204846017157373 no 693 0.203047399271103 941 830119 SGTC_2739 tacrine 100.86 µM 0.83039328003476 0.204949530338995 no 694 0.203158231878743 987 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2061 5245884 80.95 µM 0.82838766896987 0.205479289005766 no 695 0.203725493833692 1009 573863 SGTC_353 1988-1175 58.3 µM 0.82758699766451 0.205691003841693 no 696 0.203952217161486 921 2788357 SGTC_69 0096-0274 206.684 µM 0.826898599895638 0.205873134589221 no 697 0.204147268531491 1098 6741392 SGTC_2096 5468907 200 µM 0.825104142886199 0.206348347124493 no 698 0.204656233935072 1027 759785 SGTC_862 0452-0056 10.2 µM 0.824850138574817 0.206415665653084 no 699 0.204728338623245 983 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_312 4092-0653 6.84 µM 0.822946114940651 0.206920701509822 no 700 0.205269318447552 1062 1148278 SGTC_1227 3909-8010 46.6 µM 0.822920383951215 0.206927531572484 no 701 0.20527663506395 968 15982272 SGTC_1028 k015-0029 4.8 µM 0.82124409875442 0.20737277400523 no 702 0.205753621118532 1058 4588309 SGTC_2280 7785178 200 µM 0.82081335267308 0.20748727698712 no 703 0.205876295821186 968 2954328 SGTC_1900 st060200 72.8 µM 0.820331604551048 0.207615381832369 no 704 0.206013547083341 995 688945 SGTC_2195 6536160 144.242 µM 0.82014752735287 0.207664343361339 no 705 0.206066005469909 949 3834386 SGTC_2465 5809242 33.21 µM 0.819530262150624 0.207828575610159 no 706 0.206241971736897 1029 2731748 SGTC_1796 st049173 110.4 µM 0.818396221035424 0.208130503333892 no 707 0.20656548942639 979 94134 SGTC_2852 9023854 51.95 µM 0.81752505711521 0.208362618203786 no 708 0.206814217893935 1008 19798528 SGTC_1938 st074717 56.4 µM 0.815744590470451 0.20883748438987 no 709 0.207323115064658 948 17250979 SGTC_55 0767-0285 6.563 µM 0.815113901243796 0.209005847602183 no 710 0.207503557582383 1042 3116166 SGTC_1913 st060213 96.1 µM 0.811596090299105 0.2099463967224 no 711 0.20851171771943 1058 688959 SGTC_1060 3448-7350 82 µM 0.809816348292284 0.210423188315355 no 712 0.209022867585584 1001 570178 SGTC_2003 4023581 200 µM 0.80945450976832 0.210520202287146 no 713 0.209126879426421 1003 16641307 SGTC_2189 6047310 154.431 µM 0.807334022748586 0.211089261978714 no 714 0.209737033695053 1006 711535 SGTC_272 doxorubicin 8.13 µM 0.807158879116253 0.211136304276456 no 715 0.209787476718137 1070 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1908 st060353 56.5 µM 0.805876554266849 0.211480914461811 no 716 0.210157015623673 1067 4227716 SGTC_120 rhodamine 6G 52.259 µM 0.805359016006173 0.21162009020448 no 717 0.210306267438388 1128 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2746 daunorubicin 9.88 µM 0.802089092599124 0.212500672651772 no 718 0.211250711983786 923 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_516 3992-2719 87.3 µM 0.800965072609044 0.212803862161683 no 719 0.211575933139804 1048 5350887 YDR037W KRS1 SGTC_629 3448-6466 76.7 µM 0.79963960264424 0.21316171438989 no 720 0.211959817702964 1048 573744 SGTC_3030 9087619 49.47 µM 0.795951353987288 0.214159318088101 no 721 0.213030155369416 1064 25236973 SGTC_51 1013-0126 23.419 µM 0.794570943081914 0.214533391477359 no 722 0.21343156313474 1011 1627850 SGTC_1027 k015-0025 8.67 µM 0.793659974971753 0.214780459891597 no 723 0.213696703579077 1073 3598955 SGTC_969 1313-0238 134 µM 0.789297206037028 0.215965998687694 no 724 0.214969159620095 1074 5212874 SGTC_2849 9019321 12.99 µM 0.786639817453034 0.216689971577349 no 725 0.215746371771099 1006 16489627 SGTC_87 0100-0052 35.5 µM 0.784430235926975 0.217293012270998 no 726 0.216393851296244 1182 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1579 chlormadinone acetate 49.4 µM 0.783400721051309 0.21757431893667 no 727 0.216695916435445 1084 45114258 A steroidal progestin. SGTC_412 gemfibrozil 100 µM 0.78108242427574 0.218208543847617 no 728 0.217377009181235 1034 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_91 0417-1751 58.384 µM 0.779878290939512 0.218538382928675 no 729 0.217731258874603 1216 6795624 SGTC_206 4546-0025 72.014 µM 0.779285058648137 0.218700988032453 no 730 0.217905907082814 1114 6620745 YIL048W NEO1 SGTC_3150 9097574 49.47 µM 0.778680924543418 0.218866652869823 no 731 0.21808384779393 1048 17217476 SGTC_2920 7982904 15.77 µM 0.777197949223218 0.219273618347546 no 732 0.218520995984768 1017 6456808 SGTC_2016 5121758 140 µM 0.777156539339464 0.219284988492713 no 733 0.218533209935763 1124 2795203 SGTC_3196 9111891 49.47 µM 0.776652221058976 0.219423489196105 no 734 0.21868199144254 1109 18891510 SGTC_1478 0453-0656 35.7 µM 0.775942533804234 0.219618475391155 no 735 0.218891458615772 1097 5258496 SGTC_2847 9005661 71.43 µM 0.772295829576806 0.220621973415258 no 736 0.21996961744579 991 2991449 SGTC_2144 5628481 200 µM 0.772024587642625 0.220696718428583 no 737 0.220049932488947 1082 2818399 SGTC_1203 3992-3522 103 µM 0.769992819277331 0.221257065435305 no 738 0.220652076113218 1139 5322312 SGTC_1269 0831-0796 3.05 µM 0.769770563279528 0.221318411370247 no 739 0.220718002081347 1091 927758 SGTC_1449 4112-4002 201 µM 0.769483648673826 0.221397618417016 no 740 0.220803123879871 1059 2059539 SGTC_2695 st077686 51.995 µM 0.768541418437027 0.221657849083796 no 741 0.221082796853917 1089 2876092 SGTC_2194 5927483 104.545 µM 0.768464660354735 0.221679056277206 no 742 0.221105589129619 1132 760979 SGTC_2626 ethyl orsellinate 100 µM 0.76641542128137 0.222245661093556 no 743 0.221714579896361 1088 75653 A natural product. SGTC_818 4072-2707 53.5 µM 0.766236028560407 0.222295301629898 no 744 0.221767937222065 1074 882871 SGTC_847 0342-0274 5.54 µM 0.765704774547317 0.222442344326965 no 745 0.221925992749093 1118 18097 SGTC_1978 st071761 42 µM 0.764460721483698 0.222786895473014 no 746 0.222296367584846 1031 5147680 SGTC_2334 9017922 200 µM 0.762798430852285 0.223247755412077 no 747 0.222791808539053 1103 3163164 SGTC_119 0121-0043 24.815 µM 0.761695800756255 0.223553751991683 no 748 0.223120791090449 1190 1092378 SGTC_2192 5915882 198.485 µM 0.761018813309078 0.223741744411609 no 749 0.223322915160128 1051 2876149 SGTC_561 1550-0330 72.9 µM 0.760809780499794 0.223799808817183 no 750 0.223385345876529 1069 6812934 SGTC_2558 carylophyllene oxide 100 µM 0.758833539158136 0.224349185355244 no 751 0.223976069891125 1183 6708694 An oxygenated terpenoid and antifungal agent. SGTC_695 3505-6186 243 µM 0.757978015261576 0.224587250190764 no 752 0.224232072034803 1106 1819379 SGTC_280 3448-3607 3.04 µM 0.757891916328716 0.224611216694339 no 753 0.224257844992157 1089 626179 SGTC_1445 4239-0156 97.7 µM 0.754103942611048 0.225667072302964 no 754 0.225393405096185 1159 4008346 SGTC_905 2-aminofluorene 215 µM 0.751992698138987 0.226256774897044 no 755 0.226027724963493 1175 1539 An established DNA mutagen. YPR165W RHO1 SGTC_631 k072-0230 41.5 µM 0.750598885948473 0.226646564388027 no 756 0.226447045907631 1124 5773147 SGTC_2259 7964009 200 µM 0.750464627621765 0.226684130685502 no 757 0.226487459988592 1076 313134 SGTC_2386 9075165 157.42 µM 0.749683772093927 0.226902688455701 no 758 0.226722591728448 1097 16452277 SGTC_3138 9097216 49.47 µM 0.748532659605273 0.227225096046767 no 759 0.227069466566708 1140 25237486 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.747961594918522 0.22738513759534 no 760 0.227241661482942 1085 5379071 SGTC_678 1218-2179 85.9 µM 0.747958823419685 0.227385914465954 no 761 0.227242497361033 1099 6820081 YOR116C RPO31 SGTC_2294 7971431 200 µM 0.747066877201304 0.227636010925769 no 762 0.227511596419512 1032 5741572 SGTC_2988 9073640 71.4286 µM 0.746529689582091 0.227786709857955 no 763 0.227673751804308 1114 9102229 SGTC_3212 9128307 49.47 µM 0.74589342629955 0.227965275409761 no 764 0.227865898295997 1028 27243542 SGTC_526 4469-0568 170 µM 0.744544640915745 0.22834406860996 no 765 0.228273522417852 1140 2901964 SGTC_2067 5224629 34.075 µM 0.743942636148242 0.228513249874575 no 766 0.228455589923422 1124 2835000 SGTC_253 dyclonine 31.25 µM 0.742408245986853 0.228944777495146 no 767 0.228920012492433 1170 3180 An oral anasthetic. SGTC_1876 myriocin 605 nM 0.741168510437917 0.229293771004307 no 768 0.229295636929952 1140 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1236 0330-0013 258 µM 0.740863302515236 0.229379734722174 no 769 0.229388164109682 1108 4617066 SGTC_2983 9022671 12.99 µM 0.740562848007109 0.229464377253249 no 770 0.229479270676967 1085 6405161 SGTC_2251 lansoprazole 556 µM 0.739061796225456 0.229887508061939 no 771 0.229934736926014 964 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_433 pimozide 108 µM 0.73825607856633 0.230114811477215 no 772 0.230179425511868 1097 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1899 st063254 59.6 µM 0.738108779699142 0.230156379991565 no 773 0.230224174482865 1075 3093813 SGTC_1505 k297-0037 20.6 µM 0.736826614879739 0.230518391012245 no 774 0.230613897910162 1134 4089396 SGTC_1984 st072354 53.1 µM 0.733173582327865 0.231551544355772 no 775 0.231726282841769 1106 5762938 SGTC_2197 6588183 93.1375 µM 0.731216255288188 0.232106177294994 no 776 0.232323536409256 1135 884136 SGTC_2470 5664817 21.68 µM 0.730586931983482 0.232284660854191 no 777 0.232515748232875 1176 2859561 SGTC_3129 9127257 49.47 µM 0.729614993288178 0.232560464184481 no 778 0.232812777439386 1072 837894 SGTC_387 norethindrone acetate 66.7 µM 0.729319285090466 0.232644412280191 no 779 0.232903189119248 1101 541197 SGTC_797 k781-0471 270 µM 0.728242781262943 0.232950161349064 no 780 0.23323249084147 1149 23738129 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.728115697420047 0.23298627047877 no 781 0.233271382741874 1155 2724 A muscle relaxant with antifungal properties. SGTC_3084 9116877 49.47 µM 0.727251957664289 0.233231772620524 no 782 0.233535811294009 1067 27241325 SGTC_663 1486-0733 13.9 µM 0.727114120379453 0.2332709636144 no 783 0.233578024696888 1127 722445 YPR165W RHO1 SGTC_1202 1988-0068 29.6 µM 0.725168415525325 0.233824571652911 no 784 0.234174358394073 1116 2850480 SGTC_1769 st044406 64.4 µM 0.724859966263612 0.233912401001584 no 785 0.234268971502991 1146 670903 SGTC_3045 9092950 49.47 µM 0.724293691273322 0.23407369247865 no 786 0.234442724629546 1171 44120432 SGTC_1655 st012546 55.1 µM 0.722673256196931 0.23453557934014 no 787 0.234940324959299 1121 720985 YLR208W SEC13 SGTC_1142 3253-1408 9.78 µM 0.721819185710314 0.234779225305117 no 788 0.235202826086946 1146 256655 SGTC_1260 0700-1617 7.75 µM 0.719992671037778 0.235300755714694 no 789 0.235764754015462 1151 2853078 SGTC_756 0508-1999 28.3 µM 0.719983454057377 0.235303389088587 no 790 0.235767591498884 1155 6753853 SGTC_2857 9024691 58.44 µM 0.719738817250929 0.235373289962883 no 791 0.23584291077751 1182 16478292 SGTC_531 3788-1495 174 µM 0.719688785923672 0.235387586989125 no 792 0.235858316158187 1100 2896655 SGTC_718 1130-0073 349 µM 0.71701350465756 0.236152776998339 no 793 0.236682881953036 1202 6740020 SGTC_1669 st015249 58.4 µM 0.716929320775368 0.236176877678998 no 794 0.236708854522055 1244 722793 SGTC_1687 st020778 55.3625 µM 0.714787854863629 0.236790405078832 no 795 0.237370070475551 1187 4259299 SGTC_425 3825-7017 13.1 µM 0.713819635923162 0.23706808609012 no 796 0.237669358010665 1170 3397440 SGTC_549 1661-1316 519 µM 0.709812388622754 0.238219247974255 no 797 0.238910242801181 1205 2857282 SGTC_2821 7996764 71.43 µM 0.705183494478775 0.239552793386103 no 798 0.240348025804272 1255 2987135 SGTC_1588 farnesol 29.9 µM 0.704380248853214 0.239784615941378 no 799 0.2405980013915 1199 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1987 st072290 61.9 µM 0.703628796434035 0.240001601366444 no 800 0.240831986661276 1164 54697379 SGTC_3291 9121177 71.43 µM 0.698927073555785 0.241361673567511 no 801 0.242298803502882 1125 17015612 SGTC_2277 7947813 106.88 µM 0.698766757523889 0.241408122059713 no 802 0.242348903203231 1222 1246798 SGTC_420 mitomycin C 81.9 mM 0.698437632800961 0.241503494844467 no 803 0.242451774198171 1194 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1906 st060206 94.7 µM 0.698354149927612 0.241527689516709 no 804 0.242477871307574 1198 5133468 SGTC_2170 morpholine 200 µM 0.6980120788316 0.241626840938378 no 805 0.242584820109387 1192 121171 Reacts with secondary amines. SGTC_1080 nisoldipine 24.4 µM 0.697746700757886 0.241703777633009 no 806 0.242667808368924 1193 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1328 1441-0025 69.2 µM 0.697594035680499 0.241748043329181 no 807 0.242715556311578 1146 4562601 SGTC_3341 9147222 25.867 µM 0.697519684144232 0.241769603372817 no 808 0.242738812540705 1160 1939759 SGTC_1460 k062-0059 9.15 µM 0.697389025339872 0.241807493611924 no 809 0.242779683900022 1177 1373085 SGTC_1809 st050081 57.6 µM 0.696176536564736 0.242159261451383 no 810 0.243159139911568 1248 5036894 SGTC_2133 5320837 200 µM 0.69546407076398 0.242366091714026 no 811 0.243382260062648 1162 2841355 SGTC_40 0327-0103 19.753 µM 0.693305703257118 0.242993253960923 no 812 0.244058862332881 1135 409036 SGTC_68 0986-0284 82.829 µM 0.69269571322033 0.243170659266763 no 813 0.244250264938391 1152 423278 YIL048W NEO1 SGTC_2151 5563267 85.4165 µM 0.69204294159773 0.243360584414682 no 814 0.244455181144974 1197 5310824 SGTC_1836 st055642 81 µM 0.691888298758503 0.24340558978516 no 815 0.244503739751552 1182 8571 SGTC_3283 9109332 35.8195 µM 0.689845338930504 0.244000569873776 no 816 0.245145726605388 1097 17027281 SGTC_1835 st008666 49.2 µM 0.689139887668984 0.244206203602218 no 817 0.245367620454269 1141 690455 SGTC_2064 5220758 200 µM 0.688353116200665 0.244435651725418 no 818 0.245615220172843 1249 788518 SGTC_2400 5203494 178.7 µM 0.685862779480095 0.245162679921462 no 819 0.24639982161657 1188 6777674 SGTC_887 0885-0007 9.62 µM 0.68577581763988 0.245188088531526 no 820 0.246427243923829 1219 5719458 SGTC_1188 1403-0014 4.57 µM 0.685130327987009 0.245376732692656 no 821 0.246630841968449 1245 9614867 SGTC_3211 9128781 49.47 µM 0.682902648648636 0.246028370018884 no 822 0.247334180090076 1185 17194361 SGTC_794 k038-0031 316 µM 0.68290161764165 0.246028671822247 no 823 0.247334505854686 1251 6624242 SGTC_3347 9188721 44.724 µM 0.682824077167734 0.246051370565267 no 824 0.2473590067749 1211 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2966 9084041 48.03 µM 0.68231942521703 0.246199126858592 no 825 0.247518496316234 1145 17741380 SGTC_848 0368-0089 85.6 µM 0.681529931260325 0.246430377027475 no 826 0.247768117124279 1200 762535 SGTC_793 0488-0545 106 µM 0.680217036143864 0.246815193884239 no 827 0.24818352342042 1205 292548 SGTC_2203 7227154 166.4 µM 0.680099041133842 0.246849794625538 no 828 0.248220875788924 1222 896304 SGTC_2397 5161689 200 µM 0.679662105776053 0.246977943727925 no 829 0.248359217657044 1273 2259942 SGTC_2974 9094440 9.66 µM 0.679533932711354 0.247015542455006 no 830 0.248399807430567 1246 25236134 SGTC_2869 9037858 32.47 µM 0.678773520076766 0.247238667474078 no 831 0.248640687166513 1195 27187042 SGTC_1031 k035-0009 16 µM 0.676869034232464 0.247797966213957 no 832 0.249244526341769 1239 5180959 SGTC_2287 7945887 168.79 µM 0.676297412173114 0.247965968682264 no 833 0.249425917730982 1244 1245853 SGTC_367 0335-0881 7.1 µM 0.67603068259586 0.24804438257917 no 834 0.24951058235748 1194 23828853 SGTC_680 0417-1641 114 µM 0.675525077803593 0.248193057970104 no 835 0.249671112047577 1210 2835990 SGTC_320 4092-0846 5.34 µM 0.675049031787879 0.248333084894844 no 836 0.249822306939515 1201 1359356 SGTC_1371 2421-0008 32.7 µM 0.674508230259165 0.248492210463855 no 837 0.24999412750549 1207 2827552 SGTC_697 0508-1955 564 µM 0.674490759476595 0.248497351976836 no 838 0.249999679274407 1221 6243113 SGTC_1245 0418-0076 17.2 µM 0.674121052070206 0.248606167229994 no 839 0.250117178193656 1226 6790114 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.673743548048442 0.248717303431203 no 840 0.250237185222328 1205 2333 A French combination drug. SGTC_2809 7964133 12.99 µM 0.673023278945083 0.248929422155028 no 841 0.250466240586904 1230 1253665 SGTC_3162 9099653 49.47 µM 0.672918841657368 0.248960186850196 no 842 0.25049946228489 1211 25237511 SGTC_1616 st002734 56.1 µM 0.672767852560245 0.249004668157783 no 843 0.250547496328968 1206 4026101 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.671858627743339 0.249272614685873 no 844 0.25083685045524 1218 521171 SGTC_1690 st023502 41.2 µM 0.670547518369822 0.249659265461592 no 845 0.251254412670857 1217 24207482 SGTC_470 aa-861 153 µM 0.670376994300724 0.249709577009534 no 846 0.251308748187885 1209 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_63 0099-0242 26.702 µM 0.67014232170737 0.249778823788306 no 847 0.251383534044462 1239 3898502 YLR359W ADE13 SGTC_2593 nobiletin 86.24 µM 0.669394088241259 0.249999679274407 no 848 0.251622060869863 1195 72344 An anti-infammatory. SGTC_2135 5326629 150.42 µM 0.668045425244969 0.250398024643031 no 849 0.252052298367344 1212 5020077 SGTC_2441 5730946 39.09 µM 0.667817640416389 0.250465337084253 no 850 0.252125002385137 1258 1774275 SGTC_3250 9135583 49.47 µM 0.665575272628235 0.251128488216562 no 851 0.252841307993121 1257 7699353 SGTC_295 k015-0027 31 µM 0.665153893344614 0.251253209245234 no 852 0.252976033548732 1218 3887424 SGTC_1898 st060199 18.6 µM 0.662785635871825 0.251954781659543 no 853 0.253733927244021 1262 688866 SGTC_997 3996-0078 137 µM 0.661851041701631 0.252231929989593 no 854 0.254033345381003 1285 735687 SGTC_491 tetrandrine 80.3 µM 0.660514911907449 0.252628430341244 no 855 0.254461726155981 1261 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2008 4012253 172 µM 0.659747243909968 0.252856386434889 no 856 0.254708021715857 1266 603940 SGTC_2356 9061756 188.97 µM 0.658336446810044 0.253275599440983 no 857 0.255160981563793 1230 20104043 SGTC_402 epigallocatechin gallate 10 µM 0.657706427463943 0.253462925260167 no 858 0.255363395720377 1237 65064 An antioxidant. SGTC_2861 9024595 19.48 µM 0.656959864199326 0.253684997701194 no 859 0.255603361993066 1204 16482810 SGTC_45 0kpi-0036 14.9 µM 0.6548985790526 0.254298676974356 no 860 0.256266527583902 1263 2795021 SGTC_3254 9136651 49.47 µM 0.654370600677597 0.254455990128612 no 861 0.256436535255566 1239 16454030 SGTC_2199 6590217 200 µM 0.653455768663695 0.254728688469733 no 862 0.256731247865343 1211 703109 SGTC_1865 st057639 52.2 µM 0.653425234207607 0.25473779299267 no 863 0.256741087562916 1260 688818 SGTC_3052 9092717 49.47 µM 0.650373556028549 0.255648577027557 no 864 0.257725477182865 1259 25237534 SGTC_1148 3909-7663 27.7 µM 0.650095341153287 0.255731695735792 no 865 0.257815319202776 1322 4084526 SGTC_2797 7859098 81.82 µM 0.649290791176833 0.255972140239957 no 866 0.258075218437394 1290 972681 SGTC_2819 7996655 46.38 µM 0.648724838742586 0.256141349102936 no 867 0.25825812326016 1176 6456960 SGTC_1617 st002906 78 µM 0.648632980438467 0.25616881846536 no 868 0.258287816414329 1280 5150859 SGTC_1217 1183-1422 255 µM 0.648002415231617 0.256357424520447 no 869 0.258491694074609 1300 2849664 SGTC_912 3474-0017 2.18 µM 0.646676060744625 0.256754381649578 no 870 0.258920809890798 1326 3360550 SGTC_1939 st074455 53.6 µM 0.646101393072313 0.256926469983594 no 871 0.259106846630254 1325 1644229 SGTC_1691 st019933 84.6 µM 0.645580687508388 0.257082450788378 no 872 0.259275473917938 1253 6176082 SGTC_662 k832-1615 104 µM 0.645008563362699 0.257253891137454 no 873 0.259460818164426 1280 5878478 SGTC_2105 5350118 200 µM 0.644143723102484 0.257513158356308 no 874 0.259741120016599 1283 2133313 SGTC_1187 1391-0724 117 µM 0.642459823754021 0.258018357356087 no 875 0.260287333686162 1303 6997986 SGTC_73 0327-0325 16.231 µM 0.639338839343184 0.258956064313624 no 876 0.261301263534225 1304 53298 SGTC_1430 4049-0248 69.1 µM 0.637841554933992 0.25940655174577 no 877 0.261788413027658 1327 22774488 SGTC_1783 st039459 87.517 µM 0.637717207095009 0.259443982434515 no 878 0.261828891204626 1339 729761 SGTC_877 0771-0151 33.1 µM 0.637202965098777 0.259598807120737 no 879 0.261996323279189 1320 6166523 SGTC_2242 6630449 61.2675 µM 0.636817399317585 0.259714922079023 no 880 0.262121895655256 1299 691249 YDR170C SEC7 SGTC_3069 9117009 49.47 µM 0.636482043987111 0.259815937714657 no 881 0.262231140395395 1186 41904981 SGTC_1279 0874-0590 65.2 µM 0.635434390141138 0.260131642239335 no 882 0.262572572390495 1317 3523074 SGTC_1565 sinapyl alcohol 95.1 µM 0.634302894535224 0.260472833984388 no 883 0.262941583931537 1253 5280507 A phenol propionate derived from cinnamic acid. SGTC_2246 7293507 91.5585 µM 0.634223072015298 0.260496912405893 no 884 0.262967626237548 1313 887656 SGTC_946 3434-1334 87.4 µM 0.634052150658986 0.260548474598302 no 885 0.263023394211278 1281 4047976 SGTC_3080 9117754 49.47 µM 0.630780259204009 0.261536524800233 no 886 0.264092106350439 1399 9550191 SGTC_2085 5307070 144.047 µM 0.630659653319089 0.261572982251721 no 887 0.26413154261112 1255 2840351 SGTC_2629 bisabolol 100 µM 0.628902338494481 0.262104489403946 no 888 0.264706497505368 1316 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1497 4476-2978 41.3 µM 0.628266041484211 0.262297076471308 no 889 0.264914836777365 1306 1528379 SGTC_1288 0973-0013 65.5 µM 0.626109887472658 0.262950214899052 no 890 0.265621433672836 1342 4315430 SGTC_2687 chenodiol 100 µM 0.625160029490007 0.263238207811271 no 891 0.265933016242656 1323 5702181 A cholesterol synthesis inhibitor. SGTC_2581 avocatin a 64 µM 0.624969386252197 0.26329602943928 no 892 0.26599557538194 1312 6710728 A skin care supplement. SGTC_1375 2910-0797 186 µM 0.624706091543278 0.2633758967443 no 893 0.266081987190196 1310 742508 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.624219756880492 0.263523453072926 no 894 0.266241636801168 1336 5377381 SGTC_361 000s-0510 1.45 µM 0.623378736426456 0.263778722339319 no 895 0.266517833884102 1303 660 SGTC_317 4495-0002 170 µM 0.623033634018522 0.26388350542109 no 896 0.266631209880475 1264 15991618 SGTC_3306 9127676 59.7925 µM 0.622941250413661 0.263911559358154 no 897 0.266661564670047 1309 41905287 SGTC_3056 9094900 49.47 µM 0.62099015778653 0.264504398490978 no 898 0.267303049487966 1235 25236784 SGTC_795 0685-0265 78 µM 0.619647784338578 0.264912671549876 no 899 0.267744849873512 1343 302754 SGTC_3251 9135047 49.47 µM 0.619272554852902 0.265026852099734 no 900 0.267868410731624 1355 17682963 SGTC_597 k018-0003 82.8 µM 0.618802138991239 0.26517003272414 no 901 0.268023356466524 1397 6786234 SGTC_204 PMA1.184 62.41 µM 0.617736569345575 0.265494505698068 no 902 0.268374500943511 1329 2252213 YGL008C PMA1 SGTC_3035 9091303 49.47 µM 0.617397507277658 0.265597794559225 no 903 0.268486282896147 1331 25237002 SGTC_1405 3909-7894 12 µM 0.616223333481636 0.265955641873704 no 904 0.26887356520634 1359 7104060 SGTC_23 0213-0011 39.996 µM 0.614202626117333 0.266572054542403 no 905 0.269540719113885 1351 627608 SGTC_1214 0358-0031 63.7 µM 0.613665569493232 0.266736004011119 no 906 0.269718172410261 1484 4301366 SGTC_3201 9113999 49.47 µM 0.613554028920382 0.26677006084773 no 907 0.269755034785159 1368 16649224 SGTC_2511 berberine 10.47 µM 0.612762105997618 0.267011922935941 no 908 0.270016825165889 1321 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1408 3909-7976 48.8 µM 0.610731864297501 0.267632486828035 no 909 0.270688553706475 1344 24152374 SGTC_2770 toltrazuril 17.5 µM 0.609636258958072 0.267967671419811 no 910 0.271051393519983 1311 68591 Kills coccidiodes. SGTC_149 3970-0822 46.1 µM 0.609568923717839 0.267988278554512 no 911 0.271073701345471 1384 3114250 YBL034C STU1 SGTC_2232 chlorophetanol 41.5365 µM 0.605329601016687 0.269287276299696 no 912 0.272480008468963 1389 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_742 0kpi-0133 140 µM 0.604593875078076 0.269513035894856 no 913 0.272724438667991 1382 2728852 SGTC_945 3381-0768 11.3 µM 0.604023068558425 0.269688254817467 no 914 0.272914152616039 1333 1126236 YIL048W NEO1 SGTC_2638 epoxomicin 18 µM 0.604000696179357 0.26969512356759 no 915 0.272921589659685 1346 9915668 A protesome inhibitor. SGTC_669 0108-0021 26.2 µM 0.603195700894072 0.269942330868109 no 916 0.273189253663705 1511 17201 SGTC_841 0251-0215 91.2 µM 0.602908856923083 0.270030445643611 no 917 0.273284661799138 1366 3888614 SGTC_730 1436-0052 41.2 µM 0.602552896331848 0.270139812162701 no 918 0.273403081989493 1336 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1519 esterone 74 µM 0.601787557466859 0.270375032433649 no 919 0.273657779257772 1283 698 A steroid. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.600445290924587 0.270787813492728 no 920 0.274104755683627 1359 4213774 SGTC_2419 paclitaxel 166.5 µM 0.600090923470298 0.270896842953516 no 921 0.274222820639255 1267 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1493 4348-0038 111 µM 0.599945333419797 0.270941643496318 no 922 0.274271334298293 1389 800424 SGTC_1276 0871-0068 94.2 µM 0.59916023263506 0.271183296104337 no 923 0.274533019373636 1352 3414906 SGTC_2060 5238662 140 µM 0.598794166229209 0.271296007407074 no 924 0.274655076523211 1319 790130 SGTC_1574 spiramycin 23.7 µM 0.59812954259141 0.271500703697824 no 925 0.274876749691378 1307 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1153 4055-0057 267 µM 0.595436519939932 0.272330909672864 no 926 0.275775860049124 1315 882706 SGTC_762 1165-0429 115 µM 0.592914164587139 0.273109644430481 no 927 0.276619299009274 1434 5967793 SGTC_1054 3429-0080 167 µM 0.592582077467683 0.2732122528922 no 928 0.27673043822807 1390 1162877 SGTC_637 1181-0519 7.26 µM 0.591995434040341 0.273393560960784 no 929 0.276926822961031 1340 6252091 YGR060W ERG25 SGTC_189 3970-0742 2.116 µM 0.591186557040404 0.273643650221492 no 930 0.277197714458385 1372 2891807 SGTC_2731 amoxapine 43.43 µM 0.590158938914741 0.273961533198049 no 931 0.277542048829542 1401 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2444 5485484 36.41 µM 0.590030718759403 0.274001209573251 no 932 0.277585027513157 1434 6790631 SGTC_3265 9137266 49.47 µM 0.588708219167271 0.274410608750789 no 933 0.278028511674874 1324 17224265 SGTC_2075 5212009 200 µM 0.586731742869904 0.27502301826064 no 934 0.278691942680348 1355 780898 SGTC_2610 ononetin 44.17 µM 0.585334228679414 0.275456442799282 no 935 0.279161501908543 1346 259632 SGTC_822 1487-0950 154 µM 0.584977397432547 0.275567164139356 no 936 0.27928145740039 1374 1958375 SGTC_2244 6635614 200 µM 0.582280867947675 0.276404578489435 no 937 0.280188755112001 1343 836499 SGTC_571 k831-0106 44.2 µM 0.579450658687096 0.277284847767577 no 938 0.281142565273709 1427 4783639 SGTC_1204 4049-0315 18.3 µM 0.579068665542925 0.277403762582426 no 939 0.281271420983028 1479 588402 SGTC_2625 euphol 100 µM 0.578870974219544 0.277465313860777 no 940 0.28133811833696 1408 6708538 A triterpene alcohol. SGTC_515 4092-1064 102 µM 0.578811226460132 0.277483917664859 no 941 0.281358277615336 1466 717353 SGTC_1862 st057513 3.81 µM 0.578227727939552 0.277665635051638 no 942 0.281555190413319 1344 5393163 SGTC_3252 9135871 49.47 µM 0.577985078965268 0.277741219683299 no 943 0.28163709654099 1386 17682838 SGTC_1855 st056195 39.6 µM 0.577773620446801 0.277807096747974 no 944 0.281708483702559 1403 4028379 SGTC_2643 anethole 100 µM 0.576685882116996 0.278146087539105 no 945 0.28207583559874 1357 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_767 0929-0023 86 µM 0.576320939088488 0.278259866255923 no 946 0.282199136118675 1405 1204563 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.576229042051367 0.278288520679174 no 947 0.282230188758484 1467 5282309 SGTC_897 1000-0139 31.4 µM 0.576121578241297 0.278322030803799 no 948 0.282266503603557 1387 6151020 SGTC_2810 7959871 45.46 µM 0.575974937171872 0.278367760631236 no 949 0.282316061101247 1415 2974535 SGTC_3236 9132701 49.47 µM 0.575109416007678 0.278637746853145 no 950 0.282608650095678 1332 24282524 SGTC_2532 xanthone 78.9 µM 0.574638632466572 0.278784654172497 no 951 0.282767859414036 1393 7020 An insecticide. SGTC_2478 5763493 32.33 µM 0.574322525675934 0.278883315986582 no 952 0.282874784408004 1370 1365576 YLR208W SEC13 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.574243229703272 0.278908068150121 no 953 0.282901609786441 1359 15053 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.57119872057053 0.279859216260472 no 954 0.283932472701798 1381 616764 SGTC_1647 st011722 22.4 µM 0.569795528991127 0.280298122362086 no 955 0.284408194177251 1381 2854783 SGTC_1490 4089-0339 670 nM 0.569092861598819 0.280518035804531 no 956 0.284646561238754 1364 742542 SGTC_732 3970-1727 52.7 µM 0.568803965126539 0.280608475798599 no 957 0.28474459174441 1459 1275699 SGTC_1487 3970-0795 2.82 µM 0.565447270841425 0.281660332983265 no 958 0.285884789892023 1417 3765103 SGTC_126 0417-1624 672.48 µM 0.5647359415202 0.281883479759097 no 959 0.286126691894009 1440 41912 YDL195W SEC31 SGTC_1421 4029-0249 71.4 µM 0.561967278288791 0.282752830253364 no 960 0.28706915674508 1477 2894095 SGTC_2749 bexarotene 57.39 µM 0.560592539284789 0.283184971523975 no 961 0.287537669357263 1371 82146 An retinoic acid receptor inhibitor. SGTC_2807 7945238 51.95 µM 0.560474709696891 0.283222025312653 no 962 0.287577842629493 1432 17148797 SGTC_1488 4013-0813 75.9 µM 0.559731824982512 0.283455693292378 no 963 0.287831185676242 1374 2910057 SGTC_1492 4158-0558 28.5 µM 0.555610319023972 0.284753753122229 no 964 0.289238637830944 1480 3967268 SGTC_2934 9036370 36.88 µM 0.555444543632994 0.284806023034631 no 965 0.28929531604518 1470 6462800 SGTC_1521 st012942 49.4 µM 0.550711508917805 0.286300303418209 no 966 0.290915726935286 1545 24207259 SGTC_1992 st073643 23.3 µM 0.548753205744399 0.286919651900592 no 967 0.291587413743285 1420 3161292 SGTC_2860 9025725 38.96 µM 0.546530495026821 0.287623392200771 no 968 0.292350665778777 1362 40546248 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.545731155289967 0.287876673288192 no 969 0.292625376347756 1423 97141 SGTC_3238 9133470 49.47 µM 0.545364196566152 0.287992984150689 no 970 0.292751529883408 1489 3534688 SGTC_2871 9038510 12.99 µM 0.545129133243169 0.288067501236164 no 971 0.29283235351878 1529 4945164 SGTC_2247 cerulenin 830 nM 0.544101788561158 0.288393285038782 no 972 0.293185714876509 1464 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1400 3771-8998 51.5 µM 0.543674072507028 0.288528970320406 no 973 0.293332888642674 1423 670767 SGTC_277 nystatin 15.5 µM 0.540763393583284 0.289453129154866 no 974 0.29433533864047 1396 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_175 3793-3120 23.7 µM 0.54070768453541 0.289470830679608 no 975 0.294354540489503 1412 5322297 SGTC_1800 st050079 29.0735 µM 0.538303847521963 0.290235132659615 no 976 0.295183647769435 1380 3645560 SGTC_269 exalamide 29 µM 0.537964372479491 0.290343145164331 no 977 0.295300822674653 1471 3316 A derivative of salicylamide. SGTC_1379 2144-0755 36.5 µM 0.536985725369282 0.290654631606518 no 978 0.295638737153538 1468 5392327 SGTC_2110 5483698 200 µM 0.534515334189237 0.291441608884344 no 979 0.29649252160228 1435 2848765 YHR062C RPP1 SGTC_2987 9018338 71.43 µM 0.534313956515884 0.291505804320202 no 980 0.296562168912148 1449 5055682 SGTC_560 2332-1943 155 µM 0.533521196591728 0.291758585417126 no 981 0.29683642104901 1434 21177716 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.53348101462546 0.291771400642785 no 982 0.296850324930522 1495 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_18 0111-0177 500 nM 0.533084174808603 0.291897978762389 no 983 0.296987656609518 1473 721752 SGTC_2274 7947094 46.08 µM 0.532925731176911 0.291948523921571 no 984 0.29704249624568 1409 2971028 SGTC_711 k292-0785 179 µM 0.532286315588136 0.292152545516807 no 985 0.297263854286141 1414 4146315 SGTC_2768 sulfasalazine 50.2 µM 0.530859211552973 0.292608138005077 no 986 0.297758172330272 1565 5384001 An antioxidant and salicylic acid derivative. SGTC_1688 st021091 57.6 µM 0.529731649071321 0.292968337313393 no 987 0.29814900061458 1485 3656366 SGTC_2491 paeonol 100 µM 0.52864255864848 0.293316441949578 no 988 0.298526715669415 1411 11092 Increases levels of cortical cytochrome oxidase. SGTC_1218 1348-1416 30.7 µM 0.528560898460724 0.293342550618734 no 989 0.298555045580011 1429 6787668 SGTC_42 0133-0086 60.653 µM 0.525604827594842 0.294288399752921 no 990 0.299581400905541 1350 162923 Model of phenazepam hydroxylation. SGTC_3226 9131256 49.47 µM 0.52423418316892 0.2947274400478 no 991 0.300057834074212 1359 17178073 SGTC_3331 9141060 1.957 µM 0.524140735998607 0.29475738373191 no 992 0.300090328594654 1399 4906567 YPR165W RHO1 SGTC_3284 9108171 64.8615 µM 0.522948747228052 0.295139460894199 no 993 0.300504960147947 1463 8687505 SGTC_709 3807-1509 243 µM 0.520084140941005 0.296058606080889 no 994 0.301502465700512 1481 1886677 YPL242C IQG1 SGTC_2886 9058944 51.95 µM 0.519634018931179 0.296203152779798 no 995 0.301659341343421 1383 4949929 SGTC_487 nimodipine 119 µM 0.518703329218829 0.296502125758536 no 996 0.301983819857585 1448 4497 L-type voltage-gated calcium channels inhibitor SGTC_1265 0819-1001 68.8 µM 0.518575784106188 0.296543108877481 no 997 0.302028299788559 1409 3106768 SGTC_2803 7707263 71.43 µM 0.517622881956085 0.296849379907939 no 998 0.302360706815377 1452 2199229 SGTC_2187 6125751 200 µM 0.515673798823335 0.297476282613513 no 999 0.303041128649133 1466 874498 SGTC_1033 k072-0102 21.3 µM 0.514952385857305 0.297708470928895 no 1000 0.303293146368764 1551 5965931 SGTC_225 nsc-122657 1.016 µM 0.514657034912489 0.297803554115953 no 1001 0.303396351008624 1464 275685 SGTC_2448 5185112 27.17 µM 0.514253951029835 0.297933342426046 no 1002 0.303537226142197 1429 5718189 SGTC_188 3229-0966 278.469 µM 0.513527297158565 0.298167381619827 no 1003 0.303791260601015 1571 5722370 SGTC_2946 9065502 71.43 µM 0.510873361065887 0.299022866495882 no 1004 0.304719867770889 1365 16489101 SGTC_133 0724-0033 378.92 µM 0.50855297966223 0.29977174339254 no 1005 0.305532797272575 1371 280309 SGTC_671 0560-0003 407 µM 0.50827776745611 0.299860621337368 no 1006 0.305629279693689 1502 3238678 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.507981374221806 0.29995635289314 no 1007 0.305733202741527 1428 61125 An anti-inflammatory. SGTC_1744 st037937 38.9 µM 0.507069382607455 0.300251002255439 no 1008 0.306053068445122 1525 1016152 SGTC_1781 st038725 66.3 µM 0.50474312063622 0.301003170747738 no 1009 0.306869635215503 1480 4270275 YIL048W NEO1 SGTC_2806 7952793 58.44 µM 0.504071722597078 0.301220416988415 no 1010 0.307105488560719 1506 2972490 SGTC_1010 4112-3296 15.2 µM 0.503301733586614 0.301469651508018 no 1011 0.307376073898714 1586 704384 SGTC_13 0199-0087 65 µM 0.501777497287586 0.301963298654181 no 1012 0.30791202189686 1497 4589825 SGTC_1468 k284-1086 134 µM 0.499573424160875 0.302677762704177 no 1013 0.308687737300824 1486 15996457 SGTC_2902 5787006 60.46 µM 0.499513370754187 0.302697239985539 no 1014 0.308708884848328 1459 591003 SGTC_3194 9111903 49.47 µM 0.497906134089581 0.303218727791788 no 1015 0.309275101795307 1538 17087251 SGTC_3216 9129716 49.47 µM 0.49783067001221 0.303243222915183 no 1016 0.309301698351484 1418 8056934 SGTC_1946 st076057 65.1 µM 0.497652456627559 0.303301073272215 no 1017 0.309364511835016 1422 953009 SGTC_1424 4048-1941 275 µM 0.495940422642725 0.303857072650655 no 1018 0.309968222729032 1581 X1424 SGTC_760 0568-0725 82.9 µM 0.494841892248287 0.304214070152379 no 1019 0.310355865332442 1591 3916171 SGTC_1252 0493-0875 34.8 µM 0.493957900280701 0.304501483116226 no 1020 0.310667956013387 1471 3960963 SGTC_921 1561-0023 372 µM 0.490652053827523 0.305577384535166 no 1021 0.311836281575215 1459 24050882 SGTC_2266 7929956 200 µM 0.489968230385969 0.305800147828722 no 1022 0.31207818998733 1477 2967153 SGTC_489 paxilline 115 µM 0.48932441611169 0.30600994337292 no 1023 0.312306018904332 1440 105008 A toxic potassium channel blocker. SGTC_2897 9048598 12.99 µM 0.488965558467248 0.306126909598314 no 1024 0.312433040336529 1466 6467404 SGTC_114 0364-0001 490.298 µM 0.487998643575846 0.306442164642452 no 1025 0.312775400925103 1429 4003655 SGTC_315 k915-0449 187 µM 0.487868948791066 0.306484461519123 no 1026 0.312821334928253 1555 20970215 YNL149C PGA2 SGTC_2762 leflunomide 42.06 µM 0.487334123830991 0.306658909221166 no 1027 0.313010784588583 1528 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_530 4358-1714 28 µM 0.48700163517706 0.30676738152124 no 1028 0.313128586079546 1547 1564641 SGTC_337 1315-0038 354 µM 0.484699858270524 0.307518785251233 no 1029 0.313944633523849 1496 1626437 SGTC_1232 0279-0259 161 µM 0.48444589304499 0.307601740520551 no 1030 0.314034727506677 1489 1560000 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.482355005231551 0.308285082330079 no 1031 0.31477688937887 1549 5393153 SGTC_1545 lovastatin 49.4 µM 0.481540596324273 0.30855142667544 no 1032 0.31506616709646 1549 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3090 9117696 49.47 µM 0.481259075310889 0.308643518771644 no 1033 0.315166189646002 1596 7923821 SGTC_136 0097-0015 404.482 µM 0.479289577723859 0.309288123820014 no 1034 0.315866317792938 1528 4861337 SGTC_1751 st044839 27.194 µM 0.478345899890414 0.309597192350461 no 1035 0.316202016164958 1540 5291326 SGTC_852 0418-0143 439 µM 0.476274408742285 0.310276108650799 no 1036 0.316939447386815 1540 5369229 SGTC_2982 9019404 25.97 µM 0.475386603666778 0.310567278600857 no 1037 0.317255720560997 1345 22333232 SGTC_2000 st075254 36.4 µM 0.475311922449129 0.310591776922702 no 1038 0.317282331214124 1489 17234175 SGTC_1226 3909-7979 35.4 µM 0.473698079795707 0.311121384663983 no 1039 0.317857611422008 1600 6615510 SGTC_2482 5981709 142.65 µM 0.472057234728837 0.311660254911761 no 1040 0.318442968126754 1556 877755 SGTC_159 3970-0959 50 µM 0.470931330308626 0.312030246958514 no 1041 0.318844886862071 1584 6615653 SGTC_77 0828-0286 12.516 µM 0.468986118134647 0.312669924874118 no 1042 0.319539779308119 1463 745345 SGTC_972 1319-0219 195 µM 0.467254716227438 0.31323976694123 no 1043 0.320158825390923 1482 23903702 SGTC_3242 9133940 49.47 µM 0.467237245347037 0.313245519264697 no 1044 0.320165074491723 1545 17248444 SGTC_3073 9114972 49.47 µM 0.466034362426892 0.313641680157314 no 1045 0.320595452245805 1621 41905075 SGTC_3049 9092223 49.47 µM 0.465634498197849 0.313773420223363 no 1046 0.320738572564426 1540 8623917 SGTC_825 1988-2224 89.6 µM 0.465592109855489 0.313787386963538 no 1047 0.320753745859389 1527 1180859 SGTC_1515 3460-0031 42.1 µM 0.465547660700002 0.313802033017635 no 1048 0.320769657162916 1502 2876596 SGTC_41 0478-0632 82.643 µM 0.462377402218377 0.3148473928716 no 1049 0.321905350855783 1602 3750424 SGTC_1124 fisetin 1.16336 µM 0.462188736056345 0.314909650486959 no 1050 0.321972990060232 1520 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_792 4534-1957 155 µM 0.462098358400557 0.314939475914288 no 1051 0.322005393682138 1546 1717904 SGTC_1578 josamycin 24.2 µM 0.461738902533227 0.315058111479975 no 1052 0.322134284859286 1468 5282165 A P450 substrate. SGTC_338 4055-0136 114 µM 0.461544813504429 0.315122176962233 no 1053 0.322203888844753 1494 2900563 SGTC_1806 st050005 60.3 µM 0.45890159840147 0.315995210167161 no 1054 0.323152415446305 1500 5194765 SGTC_2595 hexamethylquercetagetin 100 µM 0.458099428837209 0.31626036387687 no 1055 0.323440504629884 1562 386331 SGTC_2168 5727979 200 µM 0.457709580870369 0.316389260584896 no 1056 0.32358055190269 1463 695210 SGTC_1770 st043884 66.3 µM 0.457585468128145 0.316430301069143 no 1057 0.3236251428651 1542 670149 SGTC_3119 9125183 49.47 µM 0.457430241578396 0.316481633169006 no 1058 0.323680915894501 1492 22695334 SGTC_3131 9127911 49.47 µM 0.455973591985293 0.316963506944876 no 1059 0.324204484123818 1574 45595681 SGTC_1596 piperlongumine 63 µM 0.455789192548823 0.317024530228533 no 1060 0.324270788228025 1643 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2888 9058547 12.99 µM 0.455702855232787 0.317053103537028 no 1061 0.324301834264519 1497 16476514 SGTC_3258 9138477 49.47 µM 0.454476551035754 0.317459066258911 no 1062 0.324742932808156 1583 4970355 SGTC_1623 st003709 20.3 µM 0.449305000867694 0.319173497451368 no 1063 0.326605825380111 1521 16192618 SGTC_1604 st002052 72.4 µM 0.447586423042744 0.319744086284158 no 1064 0.327225851726937 1581 6254834 YHR062C RPP1 SGTC_3118 9124250 49.47 µM 0.447531650793279 0.319762278365905 no 1065 0.32724562024331 1528 1504786 SGTC_935 2996-0153 430 µM 0.447125322869115 0.319897249858589 no 1066 0.327392288107377 1670 23738523 SGTC_125 0133-0007 11.75 µM 0.445461733550553 0.320450099180287 no 1067 0.327993053925539 1737 26541 SGTC_413 propylparaben 100 µM 0.444261260507139 0.32084929194807 no 1068 0.328426853016908 1517 7175 A pharmaceutical preservative. SGTC_803 4488-1585 147 µM 0.443860225004205 0.320982694302707 no 1069 0.328571821512809 1628 747204 SGTC_1963 st076565 50.3 µM 0.443430954758431 0.321125514406388 no 1070 0.328727025053318 1549 4914280 SGTC_1357 1503-1303 39.5 µM 0.442517122337636 0.321429638591742 no 1071 0.329057521413778 1554 292895 SGTC_2178 5812956 200 µM 0.441944679860725 0.321620208937137 no 1072 0.329264618898737 1573 5403383 SGTC_3290 9121031 71.43 µM 0.441730993385122 0.321691358785745 no 1073 0.329341939544166 1524 17014854 SGTC_1251 0490-5699 265 µM 0.439962606888451 0.32228041817697 no 1074 0.329982095122043 1686 3883818 SGTC_1667 st014849 34.6 µM 0.439490838201897 0.322437642478109 no 1075 0.330152959556077 1582 5348460 SGTC_445 e6 berbamine 66 µM 0.437010117666339 0.323264903543786 no 1076 0.331052005244367 1565 6610268 A calcium/calmodulin antagonist. SGTC_1540 guanosine 70.6 µM 0.436687782218371 0.32337245901429 no 1077 0.33116889552564 1599 6802 Guanosine is a purine nucleoside SGTC_459 nigericin 15.3 µM 0.435917771369688 0.323629452578289 no 1078 0.331448195391931 1598 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1179 1021-1431 9.29 µM 0.434388181279925 0.324140207600581 no 1079 0.332003289350796 1597 2840958 SGTC_739 1486-1183 203 µM 0.433561907500555 0.324416251692962 no 1080 0.332303300742042 1686 4346692 SGTC_1155 4088-0394 48.2 µM 0.432739809885034 0.324690996387308 no 1081 0.332601902494023 1535 2326248 SGTC_2157 5649910 96.377 µM 0.430796095053576 0.325340964372587 no 1082 0.333308319581811 1529 2858091 SGTC_719 2810-4230 27.3 µM 0.430310839389575 0.325503314313876 no 1083 0.333484771639041 1612 721079 SGTC_2659 sanguinarine 24.21 µM 0.428844633113174 0.325994057840235 no 1084 0.334018147554318 1576 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1993 st073995 70.8 µM 0.427623245667651 0.326403090074496 no 1085 0.334462719546761 1604 3098394 SGTC_1290 0986-0249 10.2 µM 0.427404339696827 0.326476421899867 no 1086 0.334542423542903 1575 53329 SGTC_865 0488-0499 301 µM 0.426771737169353 0.326688376592962 no 1087 0.334772796987215 1602 9634651 SGTC_307 1501-1223 22.3 µM 0.426668505830865 0.326722969763038 no 1088 0.334810396417935 1591 2830329 SGTC_2083 5306046 65.942 µM 0.426189464128956 0.326883517746345 no 1089 0.334984897034215 1569 539837 SGTC_2747 doxorubicin 7.63 µM 0.426104322064105 0.326912055959524 no 1090 0.335015915481209 1590 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1170 0310-0127 64.8 µM 0.425682416155114 0.327053486783642 no 1091 0.335169638315648 1635 774975 SGTC_2445 5742597 35.57 µM 0.425458133405627 0.327128680708759 no 1092 0.335251367730015 1552 1774255 SGTC_2442 5158906 48.48 µM 0.425412478390548 0.327143988050118 no 1093 0.335268005531882 1683 1893835 SGTC_2941 9056145 11.23 µM 0.418727821536958 0.329388364945342 no 1094 0.337707530192984 1548 2119517 SGTC_1294 1000-1494 117 µM 0.414830281976163 0.330699814952024 no 1095 0.339133074951005 1561 712797 YDL207W GLE1 SGTC_1432 4049-0298 68.4 µM 0.414430944910846 0.330834302290971 no 1096 0.339279265079428 1722 741646 SGTC_2601 securinine 100 µM 0.411857588876539 0.33170147124045 no 1097 0.340221904016002 1568 442872 A GABA receptor antagonist. SGTC_1063 disulfiram 1.84 µM 0.411781900726359 0.33172699030342 no 1098 0.340249644290969 1606 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2074 5212007 75.395 µM 0.408930660395786 0.332688884110349 no 1099 0.341295273846937 1725 758611 SGTC_299 1273-0059 1.44 µM 0.40749761363643 0.333172753170669 no 1100 0.341821273241832 1628 2848077 SGTC_96 0929-0093 37.281 µM 0.407155878801751 0.333288181189202 no 1101 0.341946752318235 1584 6991579 SGTC_2020 4017018 200 µM 0.406257926387533 0.333591558451592 no 1102 0.342276547982175 1606 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1792 st045773 43.6 µM 0.405223816888549 0.333941071852715 no 1103 0.342656499838196 1622 2919270 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.404371314557339 0.334229313151929 no 1104 0.342969845474486 1633 165521 SGTC_715 0868-0130 184 µM 0.404094749764251 0.334322844052431 no 1105 0.343071522809657 1778 2876258 SGTC_2037 5169046 200 µM 0.403721405961067 0.334449120770142 no 1106 0.343208798372563 1655 5718022 SGTC_1689 st020265 53.493 µM 0.402643212892871 0.334813904995087 no 1107 0.34360535754738 1721 5758320 YPR016C TIF6 SGTC_1250 0485-0349 40.2 µM 0.402541954480005 0.334848171690304 no 1108 0.343642609220686 1592 6842794 YDL195W SEC31 SGTC_3273 9137859 49.47 µM 0.40168212019415 0.335139202207146 no 1109 0.343958992401185 1666 2377234 SGTC_2311 7694451 200 µM 0.400474170798547 0.335548227426011 no 1110 0.344403652008883 1686 2163142 SGTC_2222 6885208 172.143 µM 0.400254546427479 0.335622615662063 no 1111 0.344484521314295 1643 609514 SGTC_3200 9114385 49.47 µM 0.399721952798223 0.335803035419516 no 1112 0.344680660564788 1570 17018030 YLR208W SEC13 SGTC_2906 7926292 26.41 µM 0.398813327019066 0.336110926009521 no 1113 0.345015378247737 1604 2966319 SGTC_1299 1079-1439 3.74 µM 0.398711689338204 0.336145373087819 no 1114 0.345052826874415 1583 323161 SGTC_375 3970-0961 9.27 µM 0.395714039747268 0.337161955208607 no 1115 0.3461579984926 1648 2898222 SGTC_2862 9027634 71.43 µM 0.395371800694696 0.337278093343226 no 1116 0.346284258564049 1568 5012562 SGTC_3314 9135860 59.4275 µM 0.394502909179452 0.337573019573089 no 1117 0.346604889895178 1755 25252478 SGTC_2140 5586273 200 µM 0.394161884939492 0.337688800075633 no 1118 0.34673076195624 1632 854421 SGTC_3313 9133968 57.047 µM 0.389435140301923 0.339295146288281 no 1119 0.348477140726321 1645 1494643 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.38883858832432 0.339498088155154 no 1120 0.348697776681137 1625 88881 An O-methylated flavonoid and antioxidant. SGTC_115 0527-0192 112.043 µM 0.386795581302244 0.340193454019807 no 1121 0.349453774359597 1645 4233931 SGTC_2193 5925765 200 µM 0.385256348292117 0.340717712774702 no 1122 0.350023749579488 1709 877370 SGTC_2952 9073731 13.78 µM 0.385244274354806 0.340721826344376 no 1123 0.350028221874731 1588 16457353 SGTC_284 0988-0104 32.6 µM 0.384446203121285 0.340993769825376 no 1124 0.350323880759608 1713 4666532 SGTC_1879 gemcitabine 100 µM 0.384063871905243 0.341124078810433 no 1125 0.35046555392964 1685 60750 A nucleoside analog which inhibits DNA replication. SGTC_1257 0669-0121 16 µM 0.383566774043659 0.341293531758468 no 1126 0.350649785088679 1761 4307855 SGTC_1912 st060209 90.8 µM 0.382345231068858 0.341710072705147 no 1127 0.351102654512303 1586 688787 SGTC_1962 st076595 64.5 µM 0.381198098908877 0.342101415454279 no 1128 0.351528129835143 1659 279619 SGTC_1728 st035614 33.7865 µM 0.381089673333528 0.342138413490838 no 1129 0.351568354893014 1682 15945546 SGTC_1065 prochlorperazine maleate 2.48 µM 0.381002173608975 0.34216827210873 no 1130 0.351600817832463 1663 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_456 gingerol 170 µM 0.380752772289362 0.342253383833553 no 1131 0.3516933532038 1698 442793 A herb. SGTC_2680 butyl paraben 22.24 µM 0.378840576675614 0.34290621358943 no 1132 0.352403126754345 1674 7184 An antifungal and steroid mimetic. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.377766055649538 0.343273264624862 no 1133 0.352802196024086 1727 804 An inhibitor of viral and cellular DNA polymerases. SGTC_163 TUB2.036 7.546 µM 0.377156964543718 0.34348139281597 no 1134 0.353028479993713 1687 15992207 YJR013W GPI14 SGTC_1243 0416-0003 5.65 µM 0.374296987759637 0.344459288942474 no 1135 0.354091686450249 1654 2141977 SGTC_1346 1488-2224 62.4 µM 0.373566293777328 0.344709298264921 no 1136 0.354363507448482 1781 3722427 SGTC_3257 9139206 32.98 µM 0.373193608134143 0.344836840000037 no 1137 0.354502176539198 1726 4910041 SGTC_1322 1348-1070 12 µM 0.371835254447887 0.345301849546081 no 1138 0.355007756708758 1683 6758089 SGTC_2976 9009005 19.48 µM 0.37155214405415 0.345398797073194 no 1139 0.355113162783159 1815 2993148 SGTC_996 3970-0799 1.8 µM 0.369674834912292 0.346041913914096 no 1140 0.355812392191771 1775 6615648 YGL040C HEM2 SGTC_2602 kawain 100 µM 0.368225553467164 0.346538703737127 no 1141 0.356352528983664 1670 5369129 SGTC_1053 3366-3204 134 µM 0.367711606987382 0.346714939599451 no 1142 0.356544142451475 1623 3632071 YPR165W RHO1 SGTC_1514 1189-1591 158 µM 0.366199580899242 0.347233616228226 no 1143 0.35710807744833 1746 767698 YMR146C TIF34 SGTC_1291 0993-0025 5.79 µM 0.365663063789314 0.347417728793961 no 1144 0.357308255462874 1768 4353356 SGTC_1133 3473-0247 50 µM 0.364372491911963 0.347860752100197 no 1145 0.357789936975019 1607 711311 SGTC_1645 Cervolide 78 µM 0.363630472439055 0.348115564245833 no 1146 0.358066984314992 1679 23173 A fragrance. SGTC_3048 9093155 49.47 µM 0.363539857052185 0.348146686596065 no 1147 0.358100822449694 1763 25236002 SGTC_1619 st003326 88.7 µM 0.363377569051914 0.34820242785331 no 1148 0.358161427782185 1771 2849032 SGTC_909 3448-9333 149 µM 0.362129287178939 0.348631286290668 no 1149 0.358627709393996 1615 3344074 SGTC_2128 5255449 168.493 µM 0.361026947432025 0.349010165929207 no 1150 0.35903965128486 1654 736008 SGTC_2891 9063876 19.48 µM 0.360462969207297 0.349204066292528 no 1151 0.359250472116774 1822 6472478 SGTC_2989 9073649 71.4286 µM 0.358765391957597 0.349787944769094 no 1152 0.359885302308885 1818 21367202 SGTC_3099 9120367 49.47 µM 0.358158560163343 0.349996749724927 no 1153 0.360112328548082 1682 24824940 SGTC_936 3005-4620 401 µM 0.357853381661761 0.350101775846114 no 1154 0.360226519741899 1798 777207 SGTC_2439 5492030 7.2 µM 0.357132586423113 0.350349880535507 no 1155 0.360496275225319 1794 5722370 SGTC_1929 genistein trimethyl ether 50.5 µM 0.357025288226911 0.350386819075947 no 1156 0.360536437199069 1862 136420 SGTC_864 0469-0573 172 µM 0.356798208955209 0.350464998186173 no 1157 0.360621438591496 1665 689425 SGTC_1775 st081588 35.1725 µM 0.356738430845392 0.350485579715342 no 1158 0.360643816163042 1688 1426443 YGL099W LSG1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.356091209061805 0.350708445466946 no 1159 0.360886130237488 1661 2374 Ca(2+)-ATPase inhibitor. SGTC_2653 dihydrofissinolide 100 µM 0.35578269793981 0.350814696945021 no 1160 0.361001653717615 1727 6857746 SGTC_1548 st061468 90.8 µM 0.353453294428449 0.351617321520886 no 1161 0.361874318778406 1782 390799 SGTC_2190 6049624 200 µM 0.351563038676645 0.352269119060722 no 1162 0.362582994289114 1754 2265554 SGTC_3140 9094243 49.47 µM 0.349437318254733 0.353002628097595 no 1163 0.363380510498797 1799 19291112 SGTC_2036 5160441 105 µM 0.349062087173462 0.353132163573512 no 1164 0.363521349279529 1745 134534 YIL048W NEO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.348111089980441 0.353460538468849 no 1165 0.363878378004182 1862 688664 SGTC_2177 5811945 192 µM 0.348011032233524 0.353495094289697 no 1166 0.363915949125446 1783 5343475 SGTC_3339 9145883 14.936 µM 0.347637992293145 0.353623937547647 no 1167 0.364056035053859 1781 2030670 SGTC_460 trequinsin 123 µM 0.347627263467052 0.353627643396105 no 1168 0.364060064268147 1715 5537 A vasodilator. SGTC_2438 5259590 200 µM 0.346998816714951 0.35384473965497 no 1169 0.36429610386652 1828 1201127 SGTC_930 2810-3379 265 µM 0.345908333436771 0.354221558702759 no 1170 0.364705802821884 1838 1015764 SGTC_458 nppb 133 µM 0.3451167300455 0.354495188574538 no 1171 0.365003308254823 1854 4549 A chloride channel blocker. SGTC_2364 9055074 200 µM 0.343342064510815 0.355108901752817 no 1172 0.365670569515995 1653 6470630 SGTC_151 3013-0144 2.285 µM 0.342969299782753 0.35523785874704 no 1173 0.365810778074171 1808 906558 YHR107C CDC12 SGTC_1692 fluoroquinolonic acid 71 µM 0.341594855827027 0.355713487249194 no 1174 0.366327904519333 1749 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_276 colchicine 750 µM 0.33941964761476 0.356466680507167 no 1175 0.367146809752704 1732 2833 A microtubule depolymerizer. SGTC_2104 5389443 200 µM 0.339135289100639 0.356565184689714 no 1176 0.367253907578788 1794 2244536 SGTC_2004 4023728 41.89 µM 0.338265477859921 0.356866553996019 no 1177 0.367581568300305 1838 360084 YDR527W RBA50 SGTC_201 4262-0159 12.803 µM 0.337922564562993 0.356985390022204 no 1178 0.367710771365495 1836 1341029 SGTC_308 4092-1169 104 µM 0.337062711429798 0.357283431683191 no 1179 0.368034813126169 1719 2268590 YDL196W YDL196W SGTC_177 1327-0068 8.361 µM 0.335158049332754 0.357943934144792 no 1180 0.368752932729595 1696 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_288 1315-0019 35.1 µM 0.334985396975173 0.358003827930402 no 1181 0.368818050990469 1742 6811474 SGTC_432 NS 1619 61.3 µM 0.334847369672752 0.358051712661619 no 1182 0.36887011263475 1741 4552 A K+/calcium channel activator. SGTC_1182 1222-0449 220 µM 0.334197785945997 0.358277097632159 no 1183 0.369115157302434 1739 658318 SGTC_3127 9126946 49.47 µM 0.33319017453245 0.358626804566373 no 1184 0.369495367200993 1661 27243249 SGTC_371 0195-0006 7.36 µM 0.33072263666061 0.359483701474756 no 1185 0.370427001013925 1644 3928593 SGTC_2569 tetrandrine 100 µM 0.330549526845671 0.35954384356367 no 1186 0.370492388279136 1654 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_56 0957-0365 83.25 µM 0.33047813857932 0.359568646402706 no 1187 0.370519354238029 1782 6752360 SGTC_2256 7954252 200 µM 0.329937650384701 0.359756450536126 no 1188 0.370723537028508 1723 2972920 SGTC_1841 st054148 70 µM 0.32852008548309 0.360249174450218 no 1189 0.371259230110543 1689 675442 SGTC_2585 alliin 100 µM 0.328358304565675 0.360305421805328 no 1190 0.371320382465451 1820 87310 A garlic compound which reacts with lipids. SGTC_354 2783-3500 4.88 µM 0.326633694511721 0.360905215168574 no 1191 0.371972477812822 1665 6740761 SGTC_380 3970-0968 6 µM 0.326174418031855 0.361065002367235 no 1192 0.372146197678826 1729 2891601 SGTC_3309 9129340 25.759 µM 0.32260630421462 0.362307211332011 no 1193 0.373496709371983 1783 17158987 SGTC_2390 9097792 176.6 µM 0.320789695930475 0.362940206711156 no 1194 0.374184884259913 1668 4497149 SGTC_1366 1683-0113 21.9 µM 0.31847727553998 0.36374650916221 no 1195 0.375061464746339 1728 708623 SGTC_3068 9116768 49.47 µM 0.317701713949876 0.364017069951865 no 1196 0.375355605492217 1742 41904888 SGTC_2002 4023503 131 µM 0.316551916690112 0.364418310546868 no 1197 0.375791812805147 1936 4736863 YCR052W RSC6 SGTC_973 1325-0077 65.9 µM 0.316527631121173 0.364426786998227 no 1198 0.375801027920008 1861 2835149 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.314336443429267 0.365191854969654 no 1199 0.376632761025303 1742 91467 include heat shock SGTC_534 k292-0788 63.4 µM 0.31364133991683 0.365434667366019 no 1200 0.376896728979414 1929 4146317 SGTC_1093 fluphenazine 7.97 µM 0.312936602328512 0.36568090019146 no 1201 0.377164414263349 1789 6602611 An atypical antipsychotic. SGTC_3348 9149464 3.537 µM 0.312626267980865 0.365789347477745 no 1202 0.377282309405923 1758 1951442 SGTC_1186 1319-0216 26 µM 0.311473091059065 0.366192422597874 no 1203 0.377720498206387 1911 4565136 SGTC_956 1185-0240 191 µM 0.311313821303092 0.366248104490271 no 1204 0.377781030552379 1777 1416193 SGTC_2035 5154463 94.595 µM 0.311039913042017 0.366343871443552 no 1205 0.377885139630685 1858 2769623 SGTC_1431 4049-0260 9.09 µM 0.309376804637514 0.366925525028559 no 1206 0.378517456353855 1820 3854841 SGTC_2302 7771753 200 µM 0.306966998545913 0.367768869780421 no 1207 0.379434245815038 1695 2203047 SGTC_3124 9127567 49.47 µM 0.306204598430373 0.368035815206971 no 1208 0.379724435711138 1866 17592030 SGTC_3060 1327-0027 12.5 µM 0.304774998745783 0.368536544436367 no 1209 0.380268762142358 1880 16000455 YPR107C YTH1 SGTC_194 1486-1323 56.904 µM 0.303154876628841 0.369104275661588 no 1210 0.380885917527562 1743 5178754 SGTC_2069 5228469 200 µM 0.302774348745356 0.369237663602437 no 1211 0.381030916570045 1749 2835210 SGTC_3122 9126309 49.47 µM 0.300809120097927 0.369926793271344 no 1212 0.381780026747868 1917 17591206 SGTC_3312 9133330 71.43 µM 0.299735067898899 0.370303598581138 no 1213 0.382189623700642 1862 17617324 SGTC_2838 9002687 71.43 µM 0.298146236586596 0.370861229930103 no 1214 0.3827957768134 1708 6457060 SGTC_593 1203-0218 61.7 µM 0.298124035534868 0.370869023747219 no 1215 0.382804248747672 1887 3666956 SGTC_799 1310-0557 151 µM 0.297975137899404 0.370921296556088 no 1216 0.382861069621058 1814 5354492 SGTC_1336 1486-0901 104 µM 0.29723233402194 0.371182104867349 no 1217 0.383144568878395 1826 5006114 SGTC_1627 st003713 25.6 µM 0.296779131927122 0.371341259217054 no 1218 0.383317569192081 1751 16195070 YER133W GLC7 SGTC_1019 4262-0212 3.4 µM 0.29527133610944 0.37187092131576 no 1219 0.383893305669062 1930 4677213 SGTC_2032 5185112 25.99 µM 0.294892258843976 0.372004122680059 no 1220 0.384038092840168 1837 5718189 SGTC_2918 7977171 22.06 µM 0.294421918645392 0.372169413596389 no 1221 0.384217760052268 1780 2236483 SGTC_623 k072-0108 16.9 µM 0.294409767780954 0.372173684067834 no 1222 0.384222401941461 1804 5382803 SGTC_2826 7992541 19.48 µM 0.294153296318237 0.372263825688901 no 1223 0.384320383379816 1839 2985066 SGTC_363 0455-0021 3.06 µM 0.293710837769199 0.372419352349483 no 1224 0.384489436031512 1764 4597466 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.292920115984819 0.372697347297173 no 1225 0.384791606292901 1797 65057 A dermal irritant. YDR527W RBA50 SGTC_2054 5233173 129 µM 0.291257365919927 0.37328213841954 no 1226 0.385427245819971 1830 6889 SGTC_2658 polymyxin b sulfate 77.05 µM 0.291024326064434 0.373364122167448 no 1227 0.385516357415015 1787 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3244 9134489 49.47 µM 0.289720676738059 0.373822853467529 no 1228 0.386014968344899 1772 16584271 SGTC_2864 9034755 47.6 µM 0.289210182211883 0.374002536274849 no 1229 0.386210270183971 1945 4930451 SGTC_1479 0549-0158 134 µM 0.288828535408316 0.374136885416254 no 1230 0.386356297098274 1788 5440202 SGTC_2048 5246248 200 µM 0.287665497374834 0.374546397874308 no 1231 0.386801401603936 1930 677046 SGTC_85 0868-0259 160.055 µM 0.287641526142212 0.374554839775067 no 1232 0.386810577166125 1821 83173 SGTC_273 hydroxyurea 18.1 mM 0.286866254760666 0.374827897935564 no 1233 0.387107364900088 1820 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_590 k048-0076 22.4 µM 0.283868175372887 0.375884440354414 no 1234 0.388255703013754 1913 6832814 SGTC_681 1642-0006 26.6 µM 0.283801937306678 0.375907793616204 no 1235 0.388281084895768 1811 4446530 SGTC_1943 st076331 65.2 µM 0.283498539736126 0.376014766962072 no 1236 0.388397350445172 1965 24208415 SGTC_2828 7998861 71.43 µM 0.281932578858379 0.37656705216373 no 1237 0.388997604039424 1937 2988188 SGTC_93 0109-0045 59.227 µM 0.2814914300594 0.376722682799211 no 1238 0.389166750143701 1931 88733 SGTC_3217 9129673 49.47 µM 0.279575151877176 0.377398949057316 no 1239 0.389901736546321 1820 17248312 SGTC_1779 st039427 55 µM 0.277606289539641 0.378094164327819 no 1240 0.390657301750711 1994 1124498 SGTC_747 3448-8087 38.7 µM 0.276837326202846 0.378365796548061 no 1241 0.390952509330908 1783 5168703 SGTC_567 1080-0542 68.4 µM 0.276601829705312 0.378448996468241 no 1242 0.391042929797591 1920 5950415 SGTC_772 k072-0172 35.3 µM 0.276125190994228 0.378617408157653 no 1243 0.391225956461732 1707 5861980 SGTC_2219 9098279 200 µM 0.276107866468574 0.378623529900636 no 1244 0.391232609438997 1922 902349 SGTC_3324 9138759 60.749 µM 0.275968500793612 0.378672776849898 no 1245 0.391286129907015 1840 45595710 SGTC_870 0573-2213 57.6 µM 0.275605829294712 0.37880094149038 no 1246 0.391425415944781 1771 3916321 SGTC_1804 st050076 49.1 µM 0.27529657289256 0.378910240275678 no 1247 0.391544198611621 1870 3895976 SGTC_452 diindolylmethane 8 µM 0.272833550339481 0.379781077764195 no 1248 0.392490584080876 1880 3071 Inhibits expression of several cancer promoting factors. SGTC_1002 4049-0206 172 µM 0.270343725753945 0.380662011592777 no 1249 0.393447914476435 1788 4662749 SGTC_2606 farnesol 9.78 µM 0.269425700383017 0.3809869779309 no 1250 0.393801055537129 1922 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2316 5844804 197.44 µM 0.269343091489108 0.381016224282499 no 1251 0.393832837370196 1962 776813 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.268187338463991 0.381425471278764 no 1252 0.394277560285095 1780 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3305 9127027 53.8275 µM 0.267142449738346 0.381795575879034 no 1253 0.394679742337541 1843 41905295 SGTC_1150 3909-7983 10.9 µM 0.265876951620052 0.38224396607112 no 1254 0.395166988171181 1817 23965914 SGTC_3248 9135562 49.47 µM 0.264477144792064 0.382740128393839 no 1255 0.395706136908596 1835 17650701 SGTC_281 1672-3440 14.9 µM 0.263988939260462 0.38291321844039 no 1256 0.395894220856733 1924 6833000 SGTC_768 0384-0033 77.3 µM 0.263849249320057 0.382962748890328 no 1257 0.395948041660363 1777 3965305 YMR134W ERG29 SGTC_1049 3226-0134 66 µM 0.263763796552058 0.382993049181319 no 1258 0.395980966531309 1876 5702385 SGTC_2753 fluvastatin 17.09 µM 0.263036082230595 0.383251114938341 no 1259 0.396261384220248 1854 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.262563493352539 0.383418734570834 no 1260 0.396443520541551 2054 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_319 1348-1596 45.5 µM 0.262463679245595 0.38345413981285 no 1261 0.396481991910478 1965 5380505 SGTC_1314 1222-0010 41.1 µM 0.259954982814729 0.384344322951484 no 1262 0.397449249279529 1868 3526027 SGTC_428 3448-4153 16.5 µM 0.257584253234108 0.385186111117793 no 1263 0.398363891906503 1740 3834874 SGTC_466 geldanamycin 89.2 µM 0.256723264729038 0.385491961309101 no 1264 0.398696205327832 1978 5288382 HSP90 inhibitor. SGTC_2125 5246583 200 µM 0.253421184885093 0.386665622737405 no 1265 0.399971379337901 2018 835267 SGTC_3171 9103192 49.47 µM 0.253248483056578 0.386727034953848 no 1266 0.400038101607183 1995 13018434 SGTC_2429 5902844 64.44 µM 0.252708475438067 0.386919078226123 no 1267 0.400246748986705 1982 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2295 7971645 200 µM 0.252024396173602 0.387162397544205 no 1268 0.400511103441443 1902 2978226 YKL099C UTP11 SGTC_1758 st042942 75.2445 µM 0.251859258329848 0.387221141870015 no 1269 0.400574925869493 1984 669317 SGTC_727 3032-0951 202 µM 0.251155760685483 0.387471425331503 no 1270 0.400846843165675 1882 3652836 SGTC_232 clozapine 119 µM 0.249935080124989 0.387905817977134 no 1271 0.401318776966579 1896 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2418 pentamidine 31.67 µM 0.248600720688833 0.388380825015864 no 1272 0.401834825483813 1984 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2773 thioridazine 9.09 µM 0.247222975918888 0.388871451648904 no 1273 0.402367832435674 1972 5452 An antipsychotic. SGTC_490 phenamil 164 µM 0.245458624114966 0.389500011138427 no 1274 0.40305067074946 1957 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2999 9069765 71.4286 µM 0.244354832651582 0.389893389735537 no 1275 0.403478009952083 1918 2097066 SGTC_78 0336-0123 156.75 µM 0.244110493395253 0.389980484702714 no 1276 0.403572622898594 1793 6765896 SGTC_3042 9091578 49.47 µM 0.243327655908034 0.390259565070119 no 1277 0.403875790887925 1975 25236497 SGTC_1503 4585-0012 61.3 µM 0.243311088221462 0.390265472036755 no 1278 0.40388220764919 1949 2922052 SGTC_2725 haloperidol 53.21 µM 0.242879203491026 0.390419463162733 no 1279 0.404049488235397 1931 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2972 9093619 59.92 µM 0.240711754172395 0.391192539576066 no 1280 0.404889264144759 1785 25236256 SGTC_974 1326-0144 138 µM 0.239731339269417 0.391542371162215 no 1281 0.405269269021343 1846 5411856 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.238833202221833 0.391862921377054 no 1282 0.405617461735725 1990 688798 SGTC_1364 1653-0028 37.6 µM 0.23869610250251 0.391911859510288 no 1283 0.40567061958236 1887 5718652 SGTC_1640 st009078 66.4 µM 0.238358151317241 0.392032499445151 no 1284 0.405801661247868 1960 690618 SGTC_613 3914-0030 117 µM 0.23632557027359 0.392758297494011 no 1285 0.406590023298463 1923 1145395 SGTC_1331 1472-0049 76.2 µM 0.235983357498142 0.392880532267653 no 1286 0.406722792154377 1842 24051409 SGTC_2372 9071633 200 µM 0.235743695038788 0.392966143446757 no 1287 0.406815780779677 2030 21321366 SGTC_2052 5265182 7.135 µM 0.233310516908145 0.393835605167285 no 1288 0.407760146310896 1980 1239884 SGTC_517 1365-0151 113 µM 0.233118292941729 0.393904316301101 no 1289 0.407834775236143 1907 768657 SGTC_2393 9031399 185.94 µM 0.232396082729442 0.394162502385532 no 1290 0.408115195590025 1963 1526623 YDL150W RPC53 SGTC_43 0570-0105 72.5 µM 0.231035025127428 0.394649199165009 no 1291 0.408643795942958 1892 1114046 YDL195W SEC31 SGTC_1152 3909-8331 15.9 µM 0.230568804637095 0.394815951504024 no 1292 0.408824902464272 1879 16001939 SGTC_2876 9059903 25.97 µM 0.229856737201417 0.395070672711407 no 1293 0.409101547467314 1985 6916095 SGTC_3128 9127691 49.47 µM 0.229021246424554 0.395369602170658 no 1294 0.409426201344865 1911 41316314 SGTC_648 0375-0473 33.3 µM 0.227409585866881 0.395946410498667 no 1295 0.410052633549027 1902 1713139 SGTC_1116 jasmonic acid  1.58368 µM 0.227063526734802 0.396070293758072 no 1296 0.410187172384672 1967 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1341 1486-1360 280 µM 0.22582498572853 0.396513756216237 no 1297 0.410668771599462 1878 3976547 SGTC_1706 st031321 9.9705 µM 0.22464500115395 0.396936376981444 no 1298 0.411127726824136 2002 6103185 SGTC_1797 st048695 56.8 µM 0.224590477215265 0.396955908089515 no 1299 0.41114893686615 2011 592262 YIL048W NEO1 SGTC_2155 5570423 76 µM 0.224534670631944 0.396975898923445 no 1300 0.411170646131302 1888 797402 SGTC_2116 5511452 16.8835 µM 0.222326602199928 0.397767082012777 no 1301 0.412029822353329 1938 870744 SGTC_1590 st077108 57.8 µM 0.221514894317067 0.398058034691489 no 1302 0.412345770326038 2020 5489485 SGTC_1613 st002381 52.1 µM 0.220196105595524 0.398530868813512 no 1303 0.412859214743526 2060 551167 SGTC_2925 9010536 32.5 µM 0.219382677817795 0.398822586841324 no 1304 0.413175981239041 1953 2994177 SGTC_2176 5809774 33.9695 µM 0.219113873950428 0.398918999886309 no 1305 0.413280671757722 2053 2870539 SGTC_615 k087-0205 167 µM 0.217781963182445 0.399396812963109 no 1306 0.413799499283518 1881 9642773 SGTC_339 3091-4833 71.4 µM 0.216772056295767 0.399759210063195 no 1307 0.414192995003498 1956 3240077 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.215838221156526 0.400094386279286 no 1308 0.414556927131181 2006 66535 A nucleotide analog. SGTC_1672 st016598 6.51 µM 0.213995647813659 0.400755946496309 no 1309 0.415275225556571 1889 4665860 YNL267W PIK1 SGTC_2483 5729050 27.16 µM 0.213944442610689 0.400774335362173 no 1310 0.415295191161189 2037 2865180 SGTC_3233 9132340 49.47 µM 0.212470029194389 0.401303922408706 no 1311 0.415870178616337 1892 17682950 SGTC_1264 0783-0040 158 µM 0.21203356533071 0.401460728475902 no 1312 0.416040424136572 1856 2855798 SGTC_3189 9110682 49.47 µM 0.211214288022413 0.401755108741154 no 1313 0.41636003100911 1903 17122418 SGTC_764 1951-2361 146 µM 0.210685821738299 0.401945025253406 no 1314 0.416566219447616 1838 5438930 SGTC_2965 9082772 38.63 µM 0.20993260105906 0.402215752437941 no 1315 0.416860138592933 2054 16459634 SGTC_1219 1469-0211 33.1 µM 0.209913351500852 0.402222671847269 no 1316 0.416867650698155 2024 6822282 SGTC_2499 avocadenofuran 51.48 µM 0.209597799520633 0.402336103924158 no 1317 0.416990798612135 1834 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2930 9013230 14.89 µM 0.209503546280958 0.402369986912991 no 1318 0.41702758364045 2009 2995857 SGTC_3082 9117008 49.47 µM 0.20880295284167 0.402621865417145 no 1319 0.417301033056045 1916 41448529 SGTC_605 1315-0399 119 µM 0.208747093873997 0.402641949666448 no 1320 0.417322837156388 1978 24020461 SGTC_2592 piperlongumine 83.33 µM 0.208591611781162 0.402697855044086 no 1321 0.417383529683751 1881 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2070 5230947 200 µM 0.208154465686824 0.402855046615731 no 1322 0.417554180464204 2050 2835538 SGTC_2014 4013930 200 µM 0.207703087793579 0.403017372220155 no 1323 0.417730403274153 2084 64556 SGTC_1838 st055369 84.5 µM 0.206948452541491 0.403288793286951 no 1324 0.418025057920235 2037 676036 SGTC_3342 9147791 14.508 µM 0.206222698344049 0.403549870608643 no 1325 0.418308479092428 1972 1838168 SGTC_3164 9100705 49.47 µM 0.202841546836223 0.404766745303811 no 1326 0.419629441608951 2031 17174235 SGTC_2019 4016004 108 µM 0.202634103931812 0.404841434023456 no 1327 0.419710515931353 1881 45595336 SGTC_116 0155-0182 31.788 µM 0.202371684480032 0.404935921724409 no 1328 0.419813081464037 1914 771486 SGTC_403 arphamenine a 50 µM 0.201506549983083 0.405247464421723 no 1329 0.420151254165476 1965 5487158 An arginine aminopeptidase inhibitor. SGTC_1443 4112-3303 14 µM 0.200950664875641 0.405447675339185 no 1330 0.420368575401626 1935 704433 SGTC_2113 5491891 107.031 µM 0.198894611543335 0.406188410456839 no 1331 0.421172592337227 1905 789979 SGTC_878 0828-0289 13.7 µM 0.197487353926049 0.406695597501922 no 1332 0.421723088338275 1907 745350 YLR208W SEC13 SGTC_1803 st050068 52.4 µM 0.197170516362639 0.406809809947471 no 1333 0.421847051114988 2025 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2951 9072950 58.06 µM 0.195599605689074 0.407376202975422 no 1334 0.422461784466419 2085 16488155 SGTC_1147 3809-1045 12.3 µM 0.193613569580765 0.408092546914929 no 1335 0.423239236129586 1933 325925 SGTC_450 aminopyrene 156 nM 0.193182666330298 0.408248010185282 no 1336 0.423407956651808 2036 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2894 9048625 32.47 µM 0.193058866139643 0.40829267806338 no 1337 0.42345643331696 2071 4092861 SGTC_602 3130-1533 38.1 µM 0.191583538688203 0.408825076935391 no 1338 0.42403421893806 2053 720941 SGTC_619 1652-1634 108 µM 0.191429330295866 0.408880735582471 no 1339 0.424094621347363 1934 5400454 SGTC_3050 9093513 49.47 µM 0.190969267389199 0.409046797634133 no 1340 0.424274835540644 2001 25236664 SGTC_408 cantharidin 100 µM 0.190965351398687 0.409048211200988 no 1341 0.424276369566429 1981 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_968 1309-0633 340 µM 0.190741427867926 0.409129043517408 no 1342 0.424364089886266 2083 3761976 SGTC_1620 st003704 16.5 µM 0.190733277557267 0.409131985704025 no 1343 0.424367282778435 2070 2834414 SGTC_869 0564-0080 44.1 µM 0.189416870263368 0.409607263612814 no 1344 0.424883051622341 1901 6843321 SGTC_1539 benzyladenosine 56 µM 0.189092858721481 0.409724265689404 no 1345 0.425010019217666 1974 92208 A nucleotide analog. SGTC_2504 purpurogallin 52.29 µM 0.188588438311481 0.40990643024532 no 1346 0.425207697550601 1914 5281571 An antioxidant. SGTC_523 1934-0222 13.7 µM 0.187501525880027 0.41029901990532 no 1347 0.425633713713106 1895 1361595 SGTC_521 r062-0005 13.8 µM 0.18725054668952 0.410389685662815 no 1348 0.425732097557159 1936 2832033 SGTC_3266 9136860 49.47 µM 0.187187928724512 0.410412307030878 no 1349 0.425756644520728 1977 4871271 YPR165W RHO1 SGTC_1988 st071872 53.4 µM 0.186589009832717 0.410628687537912 no 1350 0.425991442148643 2104 16414116 SGTC_1839 st053978 48 µM 0.184817168263014 0.411268986645418 no 1351 0.426686220754024 2086 3788398 SGTC_1390 3413-2614 145 µM 0.184415507042066 0.411414169872135 no 1352 0.426843752793622 1947 3421432 SGTC_2996 9066192 71.4286 µM 0.184203991051041 0.411490628667791 no 1353 0.426926714325292 1908 6472854 SGTC_278 4092-0821 23.9 µM 0.181560046930473 0.412446644238719 no 1354 0.427964002783023 2041 877900 SGTC_418 lividomycin a 100 µM 0.181424780653794 0.412495568774874 no 1355 0.428017084734497 2089 72394 An antibiotic. SGTC_2443 5493264 126.67 µM 0.18076475624243 0.412734312866929 no 1356 0.428276113886901 2054 5340055 SGTC_1990 st072050 59.8 µM 0.180555585129356 0.412809981002927 no 1357 0.428358210359942 1918 17233948 SGTC_2143 5623677 140.463 µM 0.179666468322997 0.413131657195529 no 1358 0.42870720971058 2073 5375313 SGTC_2407 paclitaxel 400 µM 0.179316087174032 0.413258438659434 no 1359 0.428844757918876 2004 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1810 st050138 53 µM 0.179299662183733 0.413264382078841 no 1360 0.428851206046408 2093 3444541 SGTC_2738 aclarubicin 5.55 µM 0.175918307323368 0.41448835421195 no 1361 0.430179061241319 2061 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_668 1682-0499 62.6 µM 0.175632965626624 0.414591679473788 no 1362 0.430291151040044 1967 682214 SGTC_3343 9148379 18.9835 µM 0.174019875666326 0.415175907436853 no 1363 0.430924921014077 2103 1955036 SGTC_1094 duloxetine 25.4 µM 0.173756837696892 0.415271192197101 no 1364 0.431028283415767 1992 60834 A selective serotonin reuptake inhibitor. SGTC_3157 9099274 49.47 µM 0.173278568644385 0.4154444565728 no 1365 0.431216234305971 2102 17217662 SGTC_1459 k035-0031 35.7 µM 0.171805695335174 0.415978143218971 no 1366 0.431795143938043 1909 3877128 YMR208W ERG12 SGTC_2732 terfenadine 20 µM 0.171654307968268 0.416033006306554 no 1367 0.431854654735432 2109 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1097 itavastatin 7.23 µM 0.170002177915894 0.416631847724088 no 1368 0.432504211927178 2018 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1600 coumarin 106 71.1 µM 0.169986793935284 0.416637424809713 no 1369 0.432510261206545 2038 100336 A hepatotoxic, DNA x-linker. SGTC_1171 0368-0077 21.4 µM 0.168516895164071 0.417170377868642 no 1370 0.433088326658067 1988 3239779 SGTC_784 4579-0127 173 µM 0.168330689427531 0.417237902869093 no 1371 0.433161565825445 2098 1948547 SGTC_2528 xanthyletin 44.79 µM 0.168091658479049 0.417324587798494 no 1372 0.433255585776035 1988 65188 An natural product with antifungal activity of unknown mechanism. SGTC_746 1095-0025 46.6 µM 0.166769197229375 0.417804252848011 no 1373 0.433775828138351 2076 6749286 SGTC_783 0848-0141 92.7 µM 0.166704467391158 0.417827733914813 no 1374 0.433801295129636 2080 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2218 6965428 192.983 µM 0.166622977059298 0.417857295349567 no 1375 0.433833356678393 2078 675684 SGTC_1957 st077035 62.4 µM 0.164738464336546 0.41854105037295 no 1376 0.434574920208864 2141 705593 SGTC_3177 9107506 49.47 µM 0.164105410489922 0.418770795729806 no 1377 0.434824081302104 2125 8897194 SGTC_468 gf-109203x 121 µM 0.163542167187249 0.41897522902007 no 1378 0.435045787711356 2120 2396 A protein kinase C inhibitor. SGTC_167 3672-0051 66.205 µM 0.16310499203926 0.419133920033335 no 1379 0.43521788467745 2053 3237971 SGTC_3155 9099265 49.47 µM 0.162869300858253 0.419219479469902 no 1380 0.435310671205062 2047 25236499 SGTC_2927 9011802 47.9 µM 0.162253070985451 0.419443198204437 no 1381 0.435553284414835 1948 43912568 SGTC_3116 9124943 49.47 µM 0.162218192723635 0.419455861337512 no 1382 0.435567016911332 1907 41905195 YPL160W CDC60 SGTC_341 1486-1430 230 µM 0.161778821507968 0.419615389505318 no 1383 0.435740015658098 2020 2054753 YPL210C SRP72 SGTC_263 alizarin 107.927 µM 0.157153372936735 0.421295607465991 no 1384 0.437561987300223 2105 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3275 9138069 49.47 µM 0.156399423351023 0.421569620281436 no 1385 0.437859095840497 2046 17617007 SGTC_1986 st071812 45 µM 0.156275011666734 0.421614839685798 no 1386 0.437908126063523 2130 11838594 SGTC_1702 st027038 51 µM 0.156074044855202 0.421687886451348 no 1387 0.437987328415985 2040 5521182 SGTC_1423 4048-0112 5.59 µM 0.156063215419672 0.42169182277603 no 1388 0.437991596438876 2129 X1423 SGTC_3218 9131285 49.47 µM 0.155750580629786 0.421805463838213 no 1389 0.438114813027039 2128 17156417 SGTC_2087 5276107 200 µM 0.154978341797356 0.422086196383581 no 1390 0.438419195868272 2096 144405 SGTC_1649 st011737 51.3 µM 0.151619820837843 0.423307580687115 no 1391 0.439743399690741 2018 1761035 SGTC_2137 5261020 140 µM 0.151295230727286 0.423425662763826 no 1392 0.439871415652772 2041 763655 SGTC_685 1278-0033 54.9 µM 0.151044399771993 0.423516916836177 no 1393 0.439970345851199 2113 3590572 SGTC_3317 9138495 8.753 µM 0.150416886385716 0.423745228595099 no 1394 0.44021785971378 2162 17020139 SGTC_2691 st077356 60.2 µM 0.149448074856805 0.42409776704235 no 1395 0.440600039692663 2084 2839272 SGTC_2539 epi(13)torulosol 80 µM 0.149130698312268 0.424213269636657 no 1396 0.44072525149334 2010 6708597 SGTC_1885 st057546 99.9 µM 0.148521573802537 0.424434966064128 no 1397 0.44096558066653 2138 702008 SGTC_2800 7887935 81.82 µM 0.148137499777192 0.424574765607948 no 1398 0.441117127687069 2046 2961002 SGTC_123 0083-0120 66.675 µM 0.146491500954768 0.42517400185919 no 1399 0.441766699399112 1944 16001701 SGTC_991 3996-0057 64.7 µM 0.146261463889207 0.425257762106665 no 1400 0.441857493006316 2074 715343 SGTC_1348 1493-0373 93.8 µM 0.145931775948595 0.425377812744714 no 1401 0.441987623263057 2095 3010129 SGTC_957 1187-1561 14.1 µM 0.145348190746765 0.425590333002815 no 1402 0.442217983978907 2156 1538454 SGTC_1398 3558-0053 112 µM 0.145152408764098 0.425661634443311 no 1403 0.442295270096428 2045 4532369 SGTC_3013 9080133 71.4286 µM 0.144487136482023 0.425903936748214 no 1404 0.44255790673357 2103 17050193 SGTC_2859 9028643 45.46 µM 0.144186530746796 0.426013431121636 no 1405 0.442676588355144 2107 17151580 SGTC_553 k007-0256 45.7 µM 0.14354094445015 0.426248602481839 no 1406 0.442931488518757 2037 6287000 SGTC_1401 3807-4679 7.6 µM 0.143519953421944 0.426256249442744 no 1407 0.442939776911655 2117 3291456 SGTC_614 0462-0418 107 µM 0.142278619498851 0.426708512415133 no 1408 0.443429966938443 2123 5188303 SGTC_3338 9144300 39.5675 µM 0.141396614920445 0.427029917277285 no 1409 0.443778314153626 2092 4901274 SGTC_867 0518-0118 155 µM 0.141128853562709 0.427127499839081 no 1410 0.443884074961142 2189 6848158 SGTC_1730 st033808 45.1 µM 0.14072769870227 0.427273704479251 no 1411 0.44404253122368 1985 1045166 SGTC_386 1509-0011 3.07 µM 0.140701847253975 0.427283126624154 no 1412 0.444052742858812 2085 3107280 SGTC_2130 NSC 7 2.4545 µM 0.14067112196322 0.427294325205101 no 1413 0.444064879769043 2140 21448 SGTC_2335 9018011 154.17 µM 0.140504864479848 0.427354922812352 no 1414 0.444130554659331 2134 6458208 SGTC_796 1234-0020 70.7 µM 0.137796024269632 0.428342482652729 no 1415 0.445200813279612 2164 46495034 SGTC_1737 st035557 69.7 µM 0.137416722322828 0.428480800450525 no 1416 0.445350706965975 2172 5716916 SGTC_2115 tiliquinol 12.7705 µM 0.137074028207596 0.428605776242234 no 1417 0.445486140578046 2098 71208 A bioactive hydroxyquinoline. SGTC_2351 9026858 72.31 µM 0.13681395093528 0.428700627596216 no 1418 0.445588928044503 2088 1409300 SGTC_1310 1188-0297 994 nM 0.136090635912471 0.428964445483731 no 1419 0.445874815057887 2094 1588352 SGTC_2938 9059746 27.26 µM 0.135968928263026 0.429008839575714 no 1420 0.44592292222971 2103 6471769 SGTC_1910 st062352 60.4 µM 0.135796645331096 0.429071683047042 no 1421 0.445991021566759 2098 2245730 SGTC_473 2-arachidonoylglycerol 10 µM 0.132364552865304 0.430323976577199 no 1422 0.447347975326342 2003 5282280 An endocannabinoid. SGTC_1411 3909-8223 150 µM 0.130442823017146 0.431025479697569 no 1423 0.448108044063602 2191 X1411 SGTC_948 3448-0295 75.3 µM 0.129970629440778 0.431197881373524 no 1424 0.448294831932648 2141 678569 SGTC_2223 6903751 107.57 µM 0.129851238090632 0.431241474194249 no 1425 0.44834206195678 2140 5598863 SGTC_2009 4012297 12.05 µM 0.128224682000402 0.431835454439938 no 1426 0.44898558394191 2048 45595307 SGTC_895 0964-0006 13.7 µM 0.127356416759107 0.432152587787771 no 1427 0.449329154833021 2179 6738897 SGTC_27 0485-0001 32.618 µM 0.126440582171078 0.432487143188044 no 1428 0.449691589991611 2177 2054479 SGTC_2455 5377712 9.75 µM 0.125469756495643 0.432841839746154 no 1429 0.450075833311329 1998 2243908 SGTC_3174 9107204 49.47 µM 0.124723777819659 0.433114423985869 no 1430 0.450371116205086 2148 3938802 SGTC_2282 7944268 200 µM 0.123246957057816 0.433654155227858 no 1431 0.450955771312833 2149 2970414 SGTC_1013 4112-3890 241 µM 0.122937816583226 0.433767151981707 no 1432 0.451078169722729 2043 705171 SGTC_2913 7966556 36.57 µM 0.122883329254831 0.43378706870336 no 1433 0.451099743447541 2178 2976516 SGTC_3054 9094397 49.47 µM 0.122801221519448 0.433817081813943 no 1434 0.451132253475205 2127 2598354 SGTC_493 zm226600 134 µM 0.121601294882465 0.43425573839238 no 1435 0.451607393966764 2141 5240098 A potassium channel opener. YCR052W RSC6 SGTC_860 0443-0016 25.1 µM 0.121174323624173 0.434411845619162 no 1436 0.451776480507525 2209 5337942 SGTC_2291 7917025 104.35 µM 0.120868657930086 0.434523607958253 no 1437 0.451897533737268 2090 2964612 SGTC_2313 7726885 200 µM 0.118558032219078 0.435368624249319 no 1438 0.452812758101872 2108 726423 SGTC_3178 9107506 49.47 µM 0.117486894618958 0.435760449142148 no 1439 0.453237114349482 2150 8897194 SGTC_1267 0828-0272 9.49 µM 0.116801432180503 0.436011226184779 no 1440 0.453508704402971 2185 745334 SGTC_1463 k081-0032 34.1 µM 0.116510494243878 0.436117673870931 no 1441 0.453623984768752 2146 977755 SGTC_469 w7 172 µM 0.116111996111482 0.43626348293611 no 1442 0.453781890800294 2214 45115570 A P450 inhibitor. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.115961415471069 0.436318582118855 no 1443 0.453841560715752 2181 6312947 SGTC_216 k038-0035 28.382 µM 0.115542552338888 0.436471855437506 no 1444 0.454007547207784 2189 4444231 YPR107C YTH1 SGTC_2046 4110841 106 µM 0.11448023864967 0.436860627395034 no 1445 0.454428555337484 2237 44119630 YMR134W ERG29 SGTC_2524 avocatin b 10.57 µM 0.113948326923714 0.437055312572763 no 1446 0.454639377838258 2184 6710748 SGTC_2607 solasodine 47.35 µM 0.113664664069936 0.437159142338313 no 1447 0.454751812458876 2094 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1914 st062367 72.6 µM 0.110335932710097 0.438377887056423 no 1448 0.45607148051965 2129 978205 SGTC_569 4130-2812 160 µM 0.109409083094054 0.438717338026699 no 1449 0.456439014865857 2253 743552 SGTC_259 usnic acid 108.925 µM 0.108035373094879 0.439220530752898 no 1450 0.45698381636958 2185 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2651 TUB2.036 5 µM 0.106207051325527 0.439890400921457 no 1451 0.457709038221871 2207 15992207 YFL037W TUB2 SGTC_495 decylubiquinone 155 µM 0.104258687115007 0.440604442271925 no 1452 0.458482031045773 2081 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1699 st031318 29.054 µM 0.102845515636967 0.441122465864305 no 1453 0.459042790256152 2182 5340658 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.102697297023021 0.441176803933931 no 1454 0.459101609483082 2209 23665772 A membrane-active detergent. SGTC_2480 5767542 37.17 µM 0.101796432032957 0.441507091663584 no 1455 0.459459128882409 2181 2867358 SGTC_2464 5717415 7.67 µM 0.100094596591186 0.442131153220917 no 1456 0.460134612542779 2185 5285744 SGTC_3153 9100258 49.47 µM 0.0998478373319729 0.442221651584592 no 1457 0.460232564540986 2118 25236848 SGTC_574 1315-0397 40 µM 0.0996851097110325 0.442281333197702 no 1458 0.460297161191317 2213 6794277 SGTC_2712 st079126 47.7 µM 0.0987952018431754 0.442607736925098 no 1459 0.460650439115563 2201 3152970 SGTC_900 1112-0045 141 µM 0.0987276054398673 0.442632531780912 no 1460 0.460677274983144 2224 56211 YIL048W NEO1 SGTC_2343 7990716 14.84 µM 0.098399046432191 0.442753052829934 no 1461 0.460807715921824 2175 6456862 SGTC_2652 actinonin 100 µM 0.0980681472969797 0.44287443763195 no 1462 0.460939090174931 2250 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2073 5212005 126 µM 0.097607156857138 0.443043553184924 no 1463 0.461122120648251 2265 691789 SGTC_3101 9120531 49.47 µM 0.0973201705298031 0.443148840115119 no 1464 0.46123606913267 2233 24824904 SGTC_488 nitrendipine 139 µM 0.0951977286429199 0.443927626403644 no 1465 0.462078887037699 2257 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2352 9027995 87.8 µM 0.0948023863485927 0.44407271312551 no 1466 0.462235895689751 2160 2997347 SGTC_2376 9072922 81.32 µM 0.0931373530016158 0.444683845974549 no 1467 0.462897221494079 2185 17087968 SGTC_1082 camptothecin 424.86 nM 0.0927909090675075 0.444811021127462 no 1468 0.463034836681928 2235 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2589 lobaric acid 100 µM 0.0925807747004487 0.444888161544301 no 1469 0.463118308853488 2129 73157 A novel microtubule depolymerizer. SGTC_2271 7849410 118.62 µM 0.0924893557308059 0.444921722139215 no 1470 0.463154623934125 2271 972430 SGTC_2911 7942208 15.64 µM 0.0902195593605279 0.445755107531462 no 1471 0.464056370793704 2125 1243384 SGTC_676 falcarinol 140 µM 0.090162890249513 0.445775917418543 no 1472 0.464078886734117 2248 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1107 amlodipine 47 µM 0.0900823363667035 0.445805498467964 no 1473 0.464110892841362 2195 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_931 2812-0076 566 µM 0.0898275349399479 0.445899068799728 no 1474 0.464212133459576 2235 3450959 SGTC_2348 9022543 33.42 µM 0.0894380228105339 0.446042114555538 no 1475 0.464366903351994 2174 3162678 YDL140C RPO21 SGTC_1859 st055998 20 µM 0.0894265457483208 0.446046329537409 no 1476 0.464371463763461 2257 676301 SGTC_863 0466-0191 129 µM 0.0890349461438441 0.446190149192108 no 1477 0.464527068693933 2257 765160 YPR165W RHO1 SGTC_1159 4092-0538 61.2 µM 0.0883775279865942 0.446431609809841 no 1478 0.464788310733255 2253 717301 SGTC_1944 st076371 56.9 µM 0.0873488750310338 0.446809459669514 no 1479 0.465197102895909 2077 24208455 SGTC_1415 3966-0071 78.1 µM 0.0870653666246866 0.446913607874483 no 1480 0.465309777121686 2249 2893185 SGTC_47 0149-0135 24.25 µM 0.0862804798098134 0.447201958976714 no 1481 0.465621727729198 2255 5239155 SGTC_347 4534-1311 26.2 µM 0.0860957794977234 0.447269818094923 no 1482 0.465695139320695 2239 2862016 SGTC_2495 cafestol 54.53 µM 0.0848947453452846 0.447711117063258 no 1483 0.466172534657294 2187 16667697 An anti-infammatory. SGTC_1755 st041960 45.185 µM 0.0841818185642159 0.447973100176316 no 1484 0.466455936777629 2179 2257073 SGTC_1925 st057770 10.1 µM 0.0835359050482795 0.4482104771564 no 1485 0.4667127145248 2041 5989122 SGTC_2324 6149169 200 µM 0.0830477356689603 0.448389894556642 no 1486 0.466906791551997 2232 2888231 SGTC_2992 9074591 71.4286 µM 0.0828148240010732 0.448475500546683 no 1487 0.466999390885114 2285 17741321 SGTC_859 0439-0102 54.6 µM 0.0825541332551971 0.44857131949945 no 1488 0.467103036540891 2272 610143 SGTC_224 benfluorex 43.875 µM 0.0824381058518278 0.448613967257598 no 1489 0.4671491675356 2258 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_982 1491-0518 27.5 µM 0.0819992440122487 0.448775283427157 no 1490 0.467323657311814 2186 3091256 SGTC_2566 crystal violet carbinol 226 nM 0.0813613608995954 0.449009770628364 no 1491 0.467577288366792 2037 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1036 k216-0215 33.5 µM 0.0805693563275643 0.449300937985931 no 1492 0.46789221853019 2280 622330 SGTC_1926 methyl fluorone black 53.6 µM 0.079125243219371 0.449831912409465 no 1493 0.468466502635568 2258 72721 Reacts with homocysteine. SGTC_2024 5144227 134 µM 0.0789908502556307 0.44988133086919 no 1494 0.468519950380816 2230 3475211 SGTC_2269 7935389 174.42 µM 0.0770716412835013 0.450587139390628 no 1495 0.469283276428293 2268 97605 SGTC_1557 sumaresinolic acid 42.3 µM 0.0769843617513073 0.450619241054146 no 1496 0.469317992779477 2250 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_752 1896-0090 130 µM 0.0755647836580509 0.451141411175828 no 1497 0.469882677448329 2279 772567 SGTC_29 0299-0004 12.984 µM 0.0736300603840349 0.451853205571073 no 1498 0.470652375662523 2258 16871 A napthoquinone isolated from Swertia calycina. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0732612847251477 0.45198889762068 no 1499 0.47079909959583 2278 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2786 7743617 45.45 µM 0.070412180861384 0.453037421334852 no 1500 0.471932798193732 2190 583674 SGTC_1122 capsaicin 818.572 nM 0.0685978215811781 0.453705310774324 no 1501 0.472654876455207 2218 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2719 novobiocin 32.65 µM 0.068405349802931 0.453776169875014 no 1502 0.472731481640541 2265 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1905 st060207 84.5 µM 0.0674107976819371 0.454142340815673 no 1503 0.473127336718173 2139 1948547 SGTC_3015 9080845 49.47 µM 0.065496388263573 0.454847291266294 no 1504 0.473889390955755 2261 5296973 SGTC_1306 1185-0270 9.02 µM 0.0645132332930526 0.455209377673809 no 1505 0.474280785208995 2273 1548076 SGTC_2138 5575593 77.673 µM 0.064031713809902 0.455386730208082 no 1506 0.474472487322607 2276 762213 SGTC_1676 st018489 23.4 µM 0.063445622514626 0.455602610469678 no 1507 0.474705829445466 2136 3696235 SGTC_400 oxethazaine 37.5 µM 0.0626198406983072 0.45590680032324 no 1508 0.475034614914939 2198 4621 A local anesthetic. SGTC_3185 9108267 49.47 µM 0.0609585603529118 0.456518837461605 no 1509 0.475696105847489 2210 4910486 SGTC_2043 5101342 149 µM 0.0598924032562584 0.456911677951292 no 1510 0.476120665179125 2247 678451 SGTC_2669 eugenol 100 µM 0.0596872214199597 0.456987284911681 no 1511 0.47620237470955 2296 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_927 2425-1185 123 µM 0.0593595831672887 0.457108018768868 no 1512 0.476332852112746 2306 730375 SGTC_814 3342-0569 96 µM 0.0585338022261389 0.457412334470266 no 1513 0.476661719179311 2303 4346283 SGTC_1522 st012842 45.6 µM 0.0576922322118871 0.457722494431996 no 1514 0.476996890594435 2296 3491067 YOR116C RPO31 SGTC_2296 7971656 126.45 µM 0.0571809093694694 0.457910954647276 no 1515 0.477200542695763 2251 666570 SGTC_2572 astragaloside iv 100 µM 0.05714027755786 0.457925930875882 no 1516 0.477216725983636 2218 45006101 An anti-inflammatory agent. SGTC_2793 7325131 81.82 µM 0.0563132190838326 0.458230784206396 no 1517 0.477546144120036 2245 4176441 SGTC_59 0330-0160 1.33 µM 0.0562178988044722 0.458265920795164 no 1518 0.477584111263607 2225 4293482 SGTC_2374 9071832 200 µM 0.055439815043603 0.458552747161121 no 1519 0.477894038389223 2307 17381698 SGTC_57 miconazole 162.5 nM 0.0552577323210056 0.458619871752473 no 1520 0.477966567704271 2313 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1386 3228-0095 33.8 µM 0.0547161349856521 0.458819537969651 no 1521 0.478182307379768 2285 870181 SGTC_1936 st074407 74.3 µM 0.0509523259031091 0.460207394626054 no 1522 0.479681754792474 2317 809813 SGTC_1447 4239-0816 81.9 µM 0.0509401455551205 0.460211886770548 no 1523 0.479686607746221 2213 1341554 SGTC_5 0352-0601 109.883 µM 0.0506098963911875 0.460333685467664 no 1524 0.479818188376624 2246 762456 SGTC_3083 9117465 49.47 µM 0.0502160711604767 0.460478936423028 no 1525 0.479975102388444 2164 16420915 SGTC_1256 0570-0116 285 µM 0.0480969227470572 0.461260612590801 no 1526 0.48081949933066 2268 410638 SGTC_2900 5328528 85.29 µM 0.04709140420761 0.461631564070463 no 1527 0.481220189093709 2312 795359 SGTC_2471 5466956 24.79 µM 0.0468305172057508 0.461727814823523 no 1528 0.481324153247907 2244 724419 SGTC_332 4112-0506 40.9 µM 0.0459042648400112 0.462069561253864 no 1529 0.481693277455875 2317 2790355 SGTC_1271 0832-2808 169 µM 0.0457251412322927 0.462135653235084 no 1530 0.481764662478872 2328 3663794 SGTC_179 1273-0063 6.77 µM 0.0448140232049327 0.462471848382377 no 1531 0.482127773710895 2313 3108139 SGTC_2854 9024559 71.43 µM 0.0439512955591862 0.462790212589519 no 1532 0.482471613416534 2285 3163529 SGTC_2657 nystatin 74.44 µM 0.0438968715581599 0.462810296964249 no 1533 0.482493304516921 2296 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3012 9080433 71.4286 µM 0.0436810000393617 0.462889962097116 no 1534 0.482579342265743 2320 17688859 SGTC_357 1325-0123 420 µM 0.0425486492302089 0.463307868662153 no 1535 0.48303066518127 2321 1098503 SGTC_203 k066-0004 30.888 µM 0.0420696566650057 0.463484658370066 no 1536 0.483221584610171 2333 6795412 SGTC_124 0136-0217 7.121 µM 0.0412367892587362 0.46379207566878 no 1537 0.483553562508633 2348 3976905 SGTC_1784 st039334 36.3 µM 0.0411679258139696 0.463817494627509 no 1538 0.48358101173905 2330 3496984 SGTC_1352 1496-0991 99 µM 0.0401993938159437 0.46417501593953 no 1539 0.483967080452884 2316 3000039 SGTC_252 miconazole 1.30953 nM 0.0400070575156395 0.46424601789923 no 1540 0.484043749857716 2341 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3240 9133527 49.47 µM 0.037913408169723 0.465018972774443 no 1541 0.484878361281155 2328 17617455 SGTC_3277 9138724 49.47 µM 0.0378035444572389 0.465059537054111 no 1542 0.484922159162907 2225 15943418 SGTC_2353 9059630 146.67 µM 0.0372973197439048 0.465246451869269 no 1543 0.485123971271057 2305 4779114 SGTC_3154 9100113 49.47 µM 0.0356096252962535 0.465869659337977 no 1544 0.485796816657073 2299 25237525 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0352343290461566 0.4660082547558 no 1545 0.485946444298451 2349 6708561 SGTC_3160 9100216 49.47 µM 0.0342813958409264 0.46636018769706 no 1546 0.486326380058813 2358 17191039 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0326665837419342 0.466956622642738 no 1547 0.486970235986165 2341 641818 YHR062C RPP1 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0315428642778807 0.467371715143679 no 1548 0.48741830419368 2339 551469 SGTC_1025 k007-0731 70 µM 0.0314384199553382 0.467410297805564 no 1549 0.487459950795105 2336 6256118 SGTC_914 3820-6779 408 µM 0.0314105925585022 0.46742057754518 no 1550 0.487471046840234 2351 2893481 SGTC_475 α-linolenic acid 10 µM 0.0312672402522731 0.467473533772674 no 1551 0.487528208059432 2342 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1694 st024011 44.9 µM 0.0304088774932951 0.467790636277489 no 1552 0.487870482457649 2355 2787533 SGTC_1359 1582-0056 520 nM 0.030151128750501 0.467885859659577 no 1553 0.487973262199511 2325 3661189 SGTC_1513 0337-0559 19 µM 0.0291498087260491 0.468255807383227 no 1554 0.488372555518801 2320 775073 SGTC_156 3474-0145 5.642 µM 0.0286168106600743 0.468452740063952 no 1555 0.488585102303575 2360 2265471 SGTC_3000 9075062 71.4286 µM 0.0286017090111723 0.468458319949611 no 1556 0.488591124524758 2323 17057871 SGTC_3272 9137413 49.47 µM 0.0281894391308608 0.468610651320734 no 1557 0.488755530115601 2357 17614870 SGTC_2557 derrustone 83.84 µM 0.0280997176732031 0.468643803497661 no 1558 0.488791309624917 2219 629853 An antioxidant. SGTC_1895 st058434 18.3 µM 0.0268262091660441 0.469114389624165 no 1559 0.489299174422989 2366 5393175 SGTC_144 4161-2749 112.381 µM 0.0259054879738011 0.469454640900199 no 1560 0.489666361373421 2349 797501 YMR168C CEP3 SGTC_2649 anisomycin 9.56 µM 0.0252870268639961 0.469683204910006 no 1561 0.489913010843272 2329 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_600 1495-0418 41.6 µM 0.0247491559694145 0.469881993405251 no 1562 0.490127523139279 2350 5377768 SGTC_3310 9130229 44.1445 µM 0.0244183012628849 0.470004275754657 no 1563 0.490259475190505 2341 7761258 SGTC_1318 1280-3875 124 µM 0.0235437140350741 0.470327532688754 no 1564 0.490608284689837 2341 373245 SGTC_2737 bleomycin 30.5 nM 0.0230279847197467 0.470518161021735 no 1565 0.490813975143277 2357 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1437 4092-1038 11.6 µM 0.0211813785501166 0.471200774674035 no 1566 0.491550484357549 2355 3977136 SGTC_3288 9119690 36.221 µM 0.0203527348919312 0.47150711746479 no 1567 0.491880994061481 2353 17595618 YKL019W RAM2 SGTC_627 1391-0720 175 µM 0.0197695881764502 0.471722712159014 no 1568 0.492113589129993 2339 997839 SGTC_1303 1160-0052 261 µM 0.019397595012173 0.471860245779818 no 1569 0.492261964475422 2365 3562476 SGTC_482 fipronil 114 µM 0.0182937946409585 0.472268363455133 no 1570 0.492702238899353 2379 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1870 st057514 26.5 µM 0.0176233536936684 0.472516265637151 no 1571 0.492969663007729 2374 5393161 SGTC_787 4152-0075 138 µM 0.0175793677088375 0.472532530263996 no 1572 0.492987208158798 2342 9566539 SGTC_1403 3909-7815 62.9 µM 0.0163468673689347 0.472988288453974 no 1573 0.493478833886791 2358 6615483 SGTC_594 1487-1584 10.8 µM 0.0149210659431996 0.473515570260371 no 1574 0.494047576800226 2375 5013332 SGTC_2123 5259487 200 µM 0.0146486266281631 0.473616327533532 no 1575 0.494156252483052 2376 2173474 SGTC_2293 7624732 200 µM 0.0132291873026799 0.474141311364645 no 1576 0.494722471787991 2377 894453 SGTC_463 ikarugamyin 104 µM 0.0127592070131526 0.474315144905317 no 1577 0.494909950966194 2384 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1048 3161-0300 24.5 µM 0.0123777849472506 0.474456226648407 no 1578 0.495062104335951 2381 2165101 SGTC_362 0310-0100 9.03 µM 0.0117989356943994 0.474670339571623 no 1579 0.49529301490175 2374 790235 SGTC_1222 0366-0074 1.18 µM 0.0097843225368055 0.475415589735337 no 1580 0.496096682334447 2385 286520 SGTC_1259 0671-0132 43 µM 0.00946670463922798 0.475533091568302 no 1581 0.496223387672477 2387 X1259 SGTC_2531 methyl deoxycholate 70.07 µM 0.00728480313478643 0.476340336768735 no 1582 0.497093809729613 2387 16667744 Haematoxylin. SGTC_1777 st045864 34.765 µM 0.00705468227153991 0.476425481052082 no 1583 0.497185612311766 2394 4691462 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.00682852093871757 0.47650916136542 no 1584 0.497275835455663 2372 688788 SGTC_2381 9035592 200 µM 0.00603714386562371 0.476801981183089 no 1585 0.497591542689362 2379 4749657 SGTC_2377 9073351 62.6 µM 0.00446716532560166 0.47738293060034 no 1586 0.498217864805329 2394 7337946 YHR072W ERG7 SGTC_439 amiodarone 34.4 µM 0.00309785408968953 0.477889665072059 no 1587 0.49876413700181 2373 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_292 k038-0015 474 µM 0.00271603187793447 0.478030970603984 no 1588 0.498916461381154 2393 46368540 SGTC_2760 etidronate 98.04 µM 0.000234600396806868 0.478949370263088 no 1589 0.499906407983573 2405 3305 A chelator and antioxidant. SGTC_2571 chrysanthemic acid 100 µM -7.68338631977317e-06 0.479039047694747 no 1590 0.49999693477234 2407 2743 An insecticide. SGTC_113 0099-0221 2.5 µM -3.52334859297744e-05 0.47904924498671 no 1591 0.49998594387278 2407 89219 SGTC_142 0335-0849 62.6745 µM -0.000667600989737356 0.47928331091199 no 1592 0.49973366575854 2407 3889043 YPR107C YTH1 SGTC_2469 5655019 90.81 µM -0.00136768763345151 0.479542450881242 no 1593 0.49945437174674 2411 2788239 SGTC_638 3970-0837 4.09 µM -0.00147387327894272 0.479581756695442 no 1594 0.499412009845958 2410 4118451 YLR208W SEC13 SGTC_370 0180-0345 38.7 µM -0.00459042998507299 0.480735472133977 no 1595 0.49816868982531 2386 3989527 SGTC_664 1222-0054 14.9 µM -0.00514726008281354 0.480941621859177 no 1596 0.497946549392199 2423 6813991 SGTC_1611 st001856 99.4 µM -0.00766302556605754 0.481873071675667 no 1597 0.496942925025505 2423 647478 SGTC_721 1187-1332 279 µM -0.00811004016612779 0.482038587136164 no 1598 0.496764597548904 2421 25730 SGTC_3089 9117425 49.47 µM -0.00811884118197 0.482041845906959 no 1599 0.496761086567164 2439 9401657 SGTC_321 4534-3890 65.3 µM -0.00864348838912185 0.482236110300697 no 1600 0.496551789967373 2433 699746 SGTC_2066 5222451 176 µM -0.00879627297178153 0.482292683596108 no 1601 0.496490840054864 2422 2281147 SGTC_2224 6650123 117.647 µM -0.0102237677063889 0.482821275478942 no 1602 0.495921377850329 2416 2908370 SGTC_670 4204-0025 119 µM -0.011007208465293 0.483111391317255 no 1603 0.495608847825184 2440 719039 SGTC_170 4197-0004 226 µM -0.0110898300203174 0.48314198741771 no 1604 0.495575888605345 2436 218692 SGTC_2774 tamoxifen 10.92 µM -0.0126169996684744 0.483707540768939 no 1605 0.494966678922079 2423 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1504 k297-0033 30 µM -0.0128465382077132 0.483792548129118 no 1606 0.494875113715563 2427 4388117 SGTC_832 4083-0019 164 µM -0.0133294326772209 0.483971385788568 no 1607 0.49468248319564 2450 1990758 SGTC_3067 9117431 49.47 µM -0.0142320697050045 0.484305681717946 no 1608 0.49432241732514 2440 17150885 SGTC_1387 3342-1166 1.8 µM -0.0169026339453785 0.485294801629868 no 1609 0.493257145741727 2465 3418228 SGTC_1121 fusaric acid 630.51 nM -0.0169891155261543 0.485326834104213 no 1610 0.493222649536057 2454 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2383 9036125 200 µM -0.0170117407432573 0.485335214420947 no 1611 0.493213624684603 2439 79580 SGTC_959 1222-0044 107 µM -0.017445820725059 0.485495997674265 no 1612 0.493040477527764 2441 6083612 SGTC_231 b-estradiol 524 µM -0.0180399934042021 0.485716083090623 no 1613 0.492803474236209 2427 450 A steroid. SGTC_3094 9117742 49.47 µM -0.0182700805117155 0.485801310020784 no 1614 0.492711697887284 2440 17149698 SGTC_1662 st014054 52 µM -0.0192714616529626 0.486172240699494 no 1615 0.492312275000827 2437 2838777 SGTC_3325 9138760 55.175 µM -0.0196176294681739 0.486300470661381 no 1616 0.49217420012877 2450 43844959 SGTC_3111 9122088 49.47 µM -0.0200338357615918 0.486454646652262 no 1617 0.492008190471212 2445 16876704 SGTC_3355 9151058 44.0485 µM -0.0202621633666366 0.486539227288983 no 1618 0.491917119422627 2438 17015728 SGTC_2767 sibutramine 71.45 µM -0.0210383250975666 0.48682674960583 no 1619 0.491607541713548 2455 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_381 3461-2219 42.7 µM -0.0218385669410157 0.487123199357511 no 1620 0.491288364772565 2452 2883159 SGTC_2811 7967822 32.47 µM -0.0224359541056622 0.487344506200191 no 1621 0.491050100167288 2472 2232244 SGTC_1498 4478-3555 97.6 µM -0.0229922376356026 0.487550589378925 no 1622 0.490828232391684 2439 3437919 SGTC_2056 5235370 200 µM -0.0233164256821901 0.487670691007675 no 1623 0.490698934738039 2455 5511916 SGTC_1695 st026914 34.495 µM -0.0233226068285661 0.487672980941829 no 1624 0.490696469487801 2452 3289191 SGTC_2750 bromebric acid 70.15 µM -0.0236609925271115 0.487798343575458 no 1625 0.490561510370933 2479 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1659 st012954 42.1 µM -0.0247700862203663 0.488209240798706 no 1626 0.490119175736269 2487 24207262 SGTC_1754 st042065 16.137 µM -0.0251843894912662 0.488362735180342 no 1627 0.489953944194693 2476 1126236 YIL048W NEO1 SGTC_1023 4482-3888 16 µM -0.0262242562054102 0.488748000840233 no 1628 0.48953923443965 2451 3303168 SGTC_3245 9134821 49.47 µM -0.026922500796156 0.489006703046344 no 1629 0.489260773490179 2439 17014901 SGTC_1991 st073000 8.92 µM -0.0272668846393199 0.489134300245269 no 1630 0.489123434636148 2473 4301969 YIL048W NEO1 SGTC_1439 4092-1168 46 µM -0.0275684719630229 0.489246041876603 no 1631 0.489003163915941 2460 2886240 SGTC_1741 st038134 10.228 µM -0.0295267189511946 0.489971615436649 no 1632 0.488222254793337 2495 1272587 SGTC_3120 9124077 49.47 µM -0.0301259662004754 0.490193656459384 no 1633 0.487983296046531 2455 18774327 YGL155W CDC43 SGTC_529 4076-0302 30.3 µM -0.0317091774674426 0.490780303294051 no 1634 0.487351988003845 2477 5816522 SGTC_821 1114-0266 29.2 µM -0.0332449034784113 0.491349373898168 no 1635 0.486739645049133 2499 3123235 SGTC_559 1550-0661 158 µM -0.0333495187520187 0.491388140240859 no 1636 0.486697932723062 2504 5830875 SGTC_3209 9113616 49.47 µM -0.033444241081518 0.491423240714252 no 1637 0.486660165048932 2470 16649353 SGTC_210 3551-0445 56.827 µM -0.034613264791727 0.491856441584237 no 1638 0.4861940620322 2511 2865180 YOR207C RET1 SGTC_2723 salbutamol 83.58 µM -0.0348778000557283 0.49195447080709 no 1639 0.486088591415067 2467 9884233 β2-adrenoceptor agonist SGTC_2136 5328288 199.296 µM -0.0351673822824802 0.492061782276761 no 1640 0.485973135651258 2476 262395 SGTC_960 1222-0186 7.7 µM -0.0354539616665147 0.492167981538453 no 1641 0.485858878271413 2507 3126296 SGTC_1295 1013-0063 9.78 µM -0.037146338655538 0.492795145838311 no 1642 0.485184162299976 2481 6826038 SGTC_2783 7738165 71.43 µM -0.0385790339236746 0.493326090772387 no 1643 0.484613009175868 2488 17201110 SGTC_1339 1486-1321 22.7 µM -0.0398255063139004 0.493788032710248 no 1644 0.484116120630554 2492 3469382 SGTC_173 1273-0061 2.693 µM -0.0399020108339734 0.493816385518231 no 1645 0.484085623983896 2525 2847414 YPL266W DIM1 SGTC_806 3966-4455 5.86 µM -0.0399020942273429 0.493816416424085 no 1646 0.484085590741229 2493 714982 SGTC_636 0kpi-0074 126 µM -0.0399042251709755 0.49381720615873 no 1647 0.484084741294258 2519 616434 SGTC_587 k089-0003 57 µM -0.0412275298962941 0.494307631752584 no 1648 0.483557253321108 2469 9659696 SGTC_161 4065-0411 162.148 µM -0.04148945970092 0.494404705735944 no 1649 0.483452847780188 2520 1906281 YLR208W SEC13 SGTC_2453 5731132 22.18 µM -0.0416528612752392 0.494465264272924 no 1650 0.483387716286768 2505 1362040 SGTC_1609 st001574 46.4 µM -0.0418418109250762 0.494535291384809 no 1651 0.483312401941727 2479 3960012 SGTC_2166 5933061 31.504 µM -0.0426154879883498 0.494822027548701 no 1652 0.483004024538476 2609 2877375 SGTC_2711 st079103 59.1 µM -0.0427347804017849 0.494866239323455 no 1653 0.482956477066717 2539 54693780 SGTC_1258 0671-0043 57.1 µM -0.0445333845338937 0.495532839598728 no 1654 0.482239620677495 2508 4298767 SGTC_2329 6138490 200 µM -0.0448438893753997 0.495647920495866 no 1655 0.48211587079901 2661 720019 SGTC_563 tetrahydrosecaminediol 614 µM -0.0450067186034824 0.495708269245002 no 1656 0.482050976855737 2517 334274 A psychoactive constituent of the cannabis plant. SGTC_1697 st025554 27.742 µM -0.0451182964693669 0.495749622962418 no 1657 0.482006508899404 2485 1269519 SGTC_2091 4-phenylthiadiazole 200 µM -0.0459493109975643 0.496057620401382 no 1658 0.48167532558172 2507 270010 SGTC_1128 3448-9350 235 µM -0.0464396285574956 0.496239347042053 no 1659 0.481479925774119 2571 619386 SGTC_2262 9014885 67.46 µM -0.047477118844282 0.496623875108519 no 1660 0.481066483141992 2549 6457424 SGTC_1618 st003135 44.5 µM -0.0475496291434192 0.496650749934672 no 1661 0.481037588351616 2483 1270615 SGTC_1828 st055811 49 µM -0.0480585330046319 0.496839367737587 no 1662 0.480834796931869 2486 5877589 SGTC_3304 9125678 46.087 µM -0.0495953523901627 0.497408971572072 no 1663 0.480222425165758 2507 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3180 9109287 49.47 µM -0.0505601501139466 0.497766565150784 no 1664 0.479838008894863 2561 18891271 SGTC_1724 st037281 8.293 µM -0.0505830411455683 0.497775049528222 no 1665 0.479828888364783 2496 574124 YDL195W SEC31 SGTC_1661 st013063 9.66 µM -0.0507011948821204 0.497818842279792 no 1666 0.479781812248704 2498 721395 SGTC_1071 trifluoperazine 6.31 µM -0.0507818513536683 0.49784873698064 no 1667 0.479749676368825 2583 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1942 st076330 65.2 µM -0.0511980913700631 0.498003013329735 no 1668 0.479583836358999 2600 24208414 SGTC_3053 9095903 49.47 µM -0.052829501189436 0.498607686232906 no 1669 0.478933877882506 2510 17174018 SGTC_1192 1488-0095 21.4 µM -0.0530320221310391 0.498682749735973 no 1670 0.478853196816251 2563 915875 SGTC_2844 9010103 25.97 µM -0.0534136580329949 0.498824201541929 no 1671 0.47870116160557 2609 2480525 SGTC_1822 st052468 42 µM -0.0540463179651551 0.499058694708058 no 1672 0.478449130871626 2522 2873678 SGTC_2045 5106652 78.05 µM -0.0544840334220998 0.499220932589179 no 1673 0.478274764588554 2525 673349 SGTC_3029 9088683 49.47 µM -0.0546415329281033 0.499279309327164 no 1674 0.478212024837247 2593 25236615 SGTC_1388 3346-4487 254 µM -0.0559566059255017 0.499766737826413 no 1675 0.477688188209909 2555 3345614 SGTC_565 1418-0001 44.5 µM -0.0560201361747501 0.499790285168188 no 1676 0.477662883000593 2566 2862145 SGTC_1932 st074806 40.9 µM -0.0562039992197568 0.499858433589688 no 1677 0.477589647642151 2706 17251235 SGTC_2122 5258151 111.688 µM -0.0565859424649567 0.5 no 1678 0.477437516444778 2541 2173356 SGTC_2283 7944793 200 µM -0.0569194310839742 0.499876393187985 no 1679 0.477304687819271 2526 2970533 SGTC_3040 9091894 49.47 µM -0.0584770622023464 0.49929906104131 no 1680 0.476684316466712 2538 25236966 SGTC_3066 9117245 49.47 µM -0.0587071985235471 0.499213761674681 no 1681 0.476592662818451 2535 17176980 SGTC_1393 3470-5649 58.2 µM -0.0587350244927171 0.499203448061467 no 1682 0.476581580985353 2578 4108395 SGTC_102 gallobenzophenone 83.616 µM -0.0590537556707146 0.499085311332263 no 1683 0.476454645974071 2508 70837 SGTC_1677 st019204 53.9 µM -0.0602858255431359 0.498628649277046 no 1684 0.475963995495061 2623 3945625 SGTC_2641 levomentholum 100 µM -0.0603571466274024 0.498602214435198 no 1685 0.475935594217705 2509 16666 SGTC_3282 9108498 15.4605 µM -0.0604002390135917 0.498586242437382 no 1686 0.475918434150672 2576 16459645 SGTC_2141 5621638 7.665 µM -0.0610627292602581 0.498340693727902 no 1687 0.475654625738629 2598 2856238 SGTC_76 0433-0009 400.328 µM -0.0611608246134071 0.498304335225142 no 1688 0.475615564363175 2648 2841569 SGTC_103 0844-0104 51.839 µM -0.0615032544200587 0.49817741561429 no 1689 0.475479211331302 2623 5375804 SGTC_815 1582-0027 36.9 µM -0.0641037256518157 0.497213573058933 no 1690 0.474443817654408 2579 3128206 SGTC_229 benomyl 22.8748 µM -0.0644033274207331 0.497102529148495 no 1691 0.474324540315435 2584 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2239 6685329 187.64 µM -0.0644403353136846 0.497088812618882 no 1692 0.474309806907064 2664 805680 SGTC_1102 cgs 12066b 26.1 µM -0.0652570511757285 0.496786107630275 no 1693 0.473984668807145 2593 6438352 A 5-HT1B full agonist. SGTC_621 3584-0052 32.1 µM -0.0670727356059629 0.496113154969621 no 1694 0.473261899419302 2527 2273927 SGTC_1338 1486-1223 76 µM -0.0671446866630191 0.496086487745001 no 1695 0.473233259663895 2592 3444526 SGTC_2978 9011784 42.97 µM -0.0671603132242154 0.496080696073988 no 1696 0.4732270396083 2676 2994934 SGTC_1172 0370-0043 85 µM -0.0678354799721726 0.495830459886432 no 1697 0.472958299933531 2608 376585 SGTC_2512 diallyl trisulfide 49.23 µM -0.0686829433457045 0.495516367954928 no 1698 0.472620997688386 2500 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2398 5228213 48.84 µM -0.0697121756045471 0.495134911511015 no 1699 0.472211375314788 2534 80771 YMR134W ERG29 SGTC_2622 2-methoxyxanthone 59.94 µM -0.0708542657923127 0.494711632621725 no 1700 0.471756871226922 2592 71034 A hepatoprotective. SGTC_1848 st056003 16.4 µM -0.0710485723502038 0.494639619743038 no 1701 0.47167954899496 2514 146492 SGTC_861 0443-0273 110 µM -0.0715107150678336 0.494468343535926 no 1702 0.471495648500539 2612 6149169 SGTC_1937 st074714 47.2 µM -0.0737612809870586 0.493634269179023 no 1703 0.470600168179394 2534 17250970 SGTC_2409 alverine citrate 63.97 µM -0.0741530736211595 0.493489071023868 no 1704 0.470444292410994 2830 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1353 1498-1206 8.11 µM -0.0742162737823966 0.49346564915587 no 1705 0.470419148477962 2522 6756808 SGTC_1223 0764-0573 147 µM -0.077142225785049 0.49238132251546 no 1706 0.469255200871786 2554 1609797 SGTC_2047 4141938 200 µM -0.0776286663483501 0.492201058066634 no 1707 0.469061719366984 2557 3807862 SGTC_1119 parthenolide 318.541 nM -0.0790167830468468 0.491686660646603 no 1708 0.468509636930459 2717 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3356 9151811 4.48 µM -0.0799146644683204 0.491353938087805 no 1709 0.468152563286888 2553 1859254 YPR165W RHO1 SGTC_3106 9121286 49.47 µM -0.0801462868321735 0.491268108137818 no 1710 0.468060454777723 2733 15943471 SGTC_1764 st044502 93.5 µM -0.0803504963020159 0.491192436641136 no 1711 0.467979248882737 2617 8407 SGTC_620 0109-0052 432 µM -0.0810253392157227 0.490942370324967 no 1712 0.467710900486757 2557 493037 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0834500306064423 0.490043919239798 no 1713 0.466746854267457 2644 6708760 SGTC_2671 danthron 100 µM -0.0843966474470444 0.489693170976625 no 1714 0.466370536363942 2588 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2985 9022375 71.43 µM -0.0847001630931883 0.489580711535726 no 1715 0.466249883152674 2747 4939335 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0849448867031906 0.489490036482384 no 1716 0.466152603146153 2609 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_513 4245-1575 41.7 µM -0.0850573730265439 0.489448358203587 no 1717 0.46610788942058 2706 719745 SGTC_67 0335-0847 266 µM -0.0855153592466187 0.489278666969588 no 1718 0.465925842643226 2889 4552207 YOR254C SEC63 SGTC_544 k015-0020 52.4 µM -0.0855335763975466 0.489271917263159 no 1719 0.465918601582111 2597 3008304 SGTC_1811 st050069 61.5 µM -0.0856093737622244 0.489243833323998 no 1720 0.465888473317549 2566 3877702 SGTC_2936 9038235 15.59 µM -0.0858760695809814 0.489145019374761 no 1721 0.465782467464497 2547 4749415 SGTC_257 daunorubicin 18.5 µM -0.0858883388157445 0.489140473494426 no 1722 0.465777590765867 2683 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2167 5876490 200 µM -0.0860475170173213 0.489081496427089 no 1723 0.465714322076837 2801 686534 SGTC_416 estradiol valerate 100 µM -0.0866910669944615 0.488843057366731 no 1724 0.465458538595409 2599 13791 A steroid. SGTC_448 monastrol 171 µM -0.0875414563299688 0.488527989234573 no 1725 0.465120567254473 2589 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1076 itraconazole 331 nM -0.0882727748380641 0.48825704240594 no 1726 0.464829938500068 2549 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_294 k038-0071 157 µM -0.0889944539768475 0.487989672187994 no 1727 0.464543158858779 2613 24152826 SGTC_1851 st056236 18.9 µM -0.0895177972917906 0.487795785491107 no 1728 0.464335205085714 2566 5393171 SGTC_209 4077-0173 175.592 µM -0.0896154041171063 0.487759624718414 no 1729 0.464296421473146 2643 15993494 SGTC_247 mechlorethamine 29.705 µM -0.0907779779341642 0.487328929384468 no 1730 0.463834504425971 2552 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_750 4073-0104 132 µM -0.0912734048950061 0.487145394463516 no 1731 0.463637674791223 2592 22330957 SGTC_1819 st053448 58.6 µM -0.0926095391269805 0.486650426422423 no 1732 0.4631068825963 2587 2857616 SGTC_504 lovastatin 124 µM -0.0931700557931297 0.486442790312741 no 1733 0.462884231451583 2578 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3198 9112019 49.47 µM -0.0932808283861715 0.486401756479349 no 1734 0.462840231199492 2578 45595555 SGTC_2440 5628896 157.78 µM -0.0948739945017574 0.485811611180018 no 1735 0.462207456353563 2595 5522048 SGTC_2477 5967686 25.23 µM -0.0960029689719495 0.485393431856665 no 1736 0.461759107278953 2589 776118 SGTC_1713 st033146 12.748 µM -0.096178669081574 0.485328352851529 no 1737 0.46168933593629 2609 674619 SGTC_1380 2291-0730 164 µM -0.0974116814068493 0.484871658391584 no 1738 0.46119973421331 2642 2999191 SGTC_582 0987-0078 156 µM -0.0985293423772566 0.484457705958417 no 1739 0.46075598673155 2589 1625765 SGTC_570 0987-0065 62.6 µM -0.100361642895455 0.483779106146079 no 1740 0.460028610253225 2570 3104428 SGTC_3301 9125354 19.7965 µM -0.10114916347878 0.483487459075043 no 1741 0.459716025662303 2586 41905162 SGTC_1787 fluconazole 80 µM -0.103883186604054 0.482475021986513 no 1742 0.45863102502734 2609 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2670 beta-carotene 100 µM -0.104957801570536 0.482077111506618 no 1743 0.458204646588885 2591 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_812 4251-0442 148 µM -0.105322049268497 0.48194224120572 no 1744 0.458060133745597 2572 5723007 SGTC_208 k072-0098 12.366 µM -0.105435878316162 0.48190009405179 no 1745 0.458014973966656 2610 5948901 SGTC_1461 k072-0203 53.8 µM -0.105486787877543 0.481881243980435 no 1746 0.457994776621404 2562 5418714 SGTC_1174 0739-0097 51.1 µM -0.106849510724816 0.48137668945294 no 1747 0.457454184195545 2634 728447 SGTC_1581 himbacine 57.9 µM -0.107173262098274 0.481256823343227 no 1748 0.457325763494749 2572 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1872 amphotericin b 148 nM -0.107900805970415 0.480987462797546 no 1749 0.457037188892051 2670 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1740 st038286 13.222 µM -0.108002144616226 0.480949944601148 no 1750 0.456996995502504 2733 716786 SGTC_2570 licareol 100 µM -0.108287140892928 0.480844432489556 no 1751 0.456883961356787 2718 443158 SGTC_2273 7815444 169.05 µM -0.108508565843136 0.480762456856647 no 1752 0.456796143037719 2595 2824616 SGTC_2411 st077133 39.94 µM -0.108617755781636 0.480722033010829 no 1753 0.456752838500848 2895 1403142 YNL221C POP1 SGTC_1821 st053465 65.6 µM -0.109207206505461 0.480503812444695 no 1754 0.456519072267106 2683 675086 SGTC_683 panaxydol 45 µM -0.113457327420575 0.478930552017804 no 1755 0.454833996177551 2673 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2792 7535235 81.82 µM -0.113746363873319 0.478823571502 no 1756 0.454719428973254 2684 1281891 SGTC_907 3448-6986 75.5 µM -0.113768807065242 0.478815264709537 no 1757 0.454710533180988 2686 590582 SGTC_130 0136-0219 337.655 µM -0.114282785825226 0.478625030708053 no 1758 0.454506814005156 2588 234244 SGTC_1632 st005650 90 µM -0.115794190872996 0.478065657309287 no 1759 0.453907827278708 2721 2759605 SGTC_1693 xanthone 101.9 µM -0.116775381850142 0.47770254003727 no 1760 0.453519026347345 2653 7020 An insecticide. SGTC_2944 9067346 25.62 µM -0.118360813755618 0.477115845692434 no 1761 0.452890886782081 2723 6473075 SGTC_1382 3002-2117 298 µM -0.118371937119599 0.477111729628354 no 1762 0.452886480179835 2656 1497314 SGTC_2816 7982706 58.44 µM -0.119160297974949 0.476820012632027 no 1763 0.452574180053375 2712 2981853 SGTC_687 k029-0044 34.9 µM -0.119837815999289 0.476569320703233 no 1764 0.452305812477591 2659 5829338 SGTC_658 3253-0951 102 µM -0.119853295825498 0.476563593041102 no 1765 0.452299681111188 2657 1184878 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.120965196277019 0.476152193530148 no 1766 0.451859301031481 2655 279621 SGTC_1474 0330-0125 5.35 µM -0.121283093613087 0.476034577214623 no 1767 0.451733405251521 2657 X1474 SGTC_1531 st059297 52.4 µM -0.122338599200977 0.475644074101351 no 1768 0.451315431915421 2723 7566702 SGTC_2430 5571206 200 µM -0.122680208325931 0.475517694706875 no 1769 0.451180168465327 2683 1731771 SGTC_2160 5660466 132.927 µM -0.123667902586555 0.475152307939074 no 1770 0.450789113275747 2591 2859134 SGTC_2765 myclobutanil 7.74 µM -0.124956906668775 0.474675486351969 no 1771 0.45027883318038 2721 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2094 5332512 191.667 µM -0.125662931503397 0.474414332702234 no 1772 0.449999372788525 2739 755774 SGTC_2959 9079155 11 µM -0.127061605095699 0.473897005690447 no 1773 0.44944581989606 2781 16189457 SGTC_856 0433-0016 11.3 µM -0.127723053659067 0.473652371171042 no 1774 0.449184072665548 2707 3911780 SGTC_1729 st035615 45.989 µM -0.127898841155206 0.473587358426082 no 1775 0.449114514069662 2788 17385451 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.129419156863585 0.473025118746843 no 1776 0.448512995084333 2649 6708514 SGTC_2314 7727897 200 µM -0.129752526952718 0.472901839727279 no 1777 0.448381111648754 2660 900724 SGTC_3009 9080819 71.4286 µM -0.130712312808331 0.472546929020664 no 1778 0.448001445853345 2707 17027216 SGTC_655 k060-0012 42 µM -0.131408598383397 0.472289469372663 no 1779 0.447726043560818 2652 5994525 SGTC_430 0958-0115 16.4 µM -0.132758080956141 0.471790515636296 no 1780 0.447192353688691 2676 6833180 SGTC_525 k781-2675 26.7 µM -0.135838001807801 0.470651921781345 no 1781 0.44597467419175 2639 3651118 YDL195W SEC31 SGTC_858 0438-0351 2.77 µM -0.135855456955946 0.470645469587604 no 1782 0.44596777455388 2662 2799119 SGTC_2705 st078069 42.8 µM -0.137206821678219 0.470145969020317 no 1783 0.445433659494732 2715 1530061 SGTC_230 MPP+ 141.667 µM -0.138354309635672 0.469721863607345 no 1784 0.444980202643854 2681 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3322 9139058 2.11 µM -0.139355919717887 0.469351701935468 no 1785 0.444584451685343 2803 4908926 YPR165W RHO1 SGTC_70 0141-0289 43.283 µM -0.139570808220883 0.469272289753763 no 1786 0.444499553242433 2770 352408 SGTC_3260 9137109 49.47 µM -0.141893436247577 0.468414039765687 no 1787 0.443582089487448 2720 17478346 SGTC_2960 9079389 5.97 µM -0.142028824862376 0.468364015891805 no 1788 0.443528618765221 2740 16457355 SGTC_2516 gossypol 71.55 µM -0.142902491462004 0.468041222450376 no 1789 0.443183595433928 2781 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2831 7999036 19.48 µM -0.143241993084991 0.467915792504017 no 1790 0.443049533034847 2937 2988270 SGTC_3003 9075612 71.4286 µM -0.143693391868129 0.467749026733671 no 1791 0.442871294784981 2757 6501993 SGTC_950 1165-0508 94.1 µM -0.144852483020558 0.467320835516695 no 1792 0.442413671849767 2748 6148369 SGTC_2142 5622915 118.518 µM -0.144852641679204 0.467320776907627 no 1793 0.442413609214697 2692 5322196 SGTC_1749 st037932 54.2 µM -0.145768241248654 0.466982563013066 no 1794 0.44205217393669 2790 594497 SGTC_1748 st037455 53.6035 µM -0.146249915125482 0.466804646753414 no 1795 0.441862051282389 2818 580690 SGTC_1875 nocodazole 6 µM -0.147903508770825 0.466193908252387 no 1796 0.441209459533154 2664 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_291 SEC14.278 35.5 µM -0.148663461196643 0.465913253931295 no 1797 0.440909597259623 2737 1068044 SGTC_2868 9035608 32.47 µM -0.150266215946363 0.465321404140421 no 1798 0.440277293039355 2637 6462614 SGTC_1919 st067113 52.3 µM -0.151743867137938 0.464775819307235 no 1799 0.439694478401768 2808 1268243 SGTC_2744 captopril 92.04 µM -0.153113729595235 0.46427009182547 no 1800 0.43915429444686 2731 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_12 0849-0099 9.267 µM -0.154294846975928 0.463834091788093 no 1801 0.438688630091045 2647 6071388 SGTC_2339 9000433 200 µM -0.154381483498284 0.463802112311921 no 1802 0.43865447632721 2739 2988954 SGTC_2340 7987427 183.45 µM -0.154774888891873 0.463656900536367 no 1803 0.438499394193927 2793 2239331 SGTC_1472 k841-0093 193 µM -0.158264354239153 0.462369101176956 no 1804 0.437124247647353 2790 X1472 SGTC_3253 9135987 49.47 µM -0.158908842971886 0.462131293105525 no 1805 0.436870346772253 2812 4182430 SGTC_500 h-89 112 µM -0.159549963257022 0.461894741378402 no 1806 0.436617798719049 2870 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_656 4090-1979 187 µM -0.160440352893552 0.461566240057184 no 1807 0.436267102151356 2764 22330961 SGTC_3213 9129884 49.47 µM -0.163807078728006 0.46032435543732 no 1808 0.43494150946892 2800 17190742 SGTC_1196 1588-0294 184 µM -0.164014626976229 0.460247809624374 no 1809 0.434859814541226 2748 6144269 SGTC_2956 9076196 2.52 µM -0.164151990839477 0.460197149305338 no 1810 0.434805747047979 2779 16423868 SGTC_889 0919-1524 82.7 µM -0.16619716163777 0.459442959350962 no 1811 0.434000896535098 2771 3905452 SGTC_2057 5236571 38.335 µM -0.167250458557937 0.459054595760705 no 1812 0.433586491659929 2813 54684039 YBR257W POP4 SGTC_738 1315-0003 72.4 µM -0.167652358453148 0.458906420581791 no 1813 0.433428389008625 2850 6251474 SGTC_2820 7989630 71.43 µM -0.167666339900031 0.458901265909779 no 1814 0.433422889064867 2736 2984098 SGTC_2805 7950783 58.44 µM -0.169502017695399 0.458224549585269 no 1815 0.432700892716822 2835 1178958 YDL195W SEC31 SGTC_2378 9074213 121.43 µM -0.169812137066917 0.458110237043262 no 1816 0.432578940781574 2713 657714 SGTC_2457 5731572 11.68 µM -0.170603288268144 0.457818627942301 no 1817 0.432267856085347 2861 2865357 SGTC_1356 1502-0781 85.8 µM -0.170842005927916 0.457730643850316 no 1818 0.432173999318135 2704 567702 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.17113927673399 0.457621081740137 no 1819 0.432057126526558 2909 165506 SGTC_1874 staurosporine 7.6 µM -0.171972570427629 0.457313980259893 no 1820 0.431729546665902 2831 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_941 3237-0776 460 µM -0.173209543263462 0.456858154200678 no 1821 0.431243361291044 2873 760008 SGTC_2895 9054447 58.44 µM -0.173752003297502 0.456658274857631 no 1822 0.431030183167228 2724 2697450 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.17378575854943 0.456645837478194 no 1823 0.431016918556085 2732 279621 SGTC_3016 9080866 49.47 µM -0.174350916153501 0.456437607176165 no 1824 0.43079484332608 2729 17066299 SGTC_628 1636-0253 16 µM -0.17614107614838 0.455778108343293 no 1825 0.430091555639401 2811 4456143 SGTC_22 0964-0034 14.468 µM -0.176376918090984 0.455691232702231 no 1826 0.429998918540876 2741 138402 SGTC_1162 k048-0130 20.1 µM -0.176705283853217 0.455570278161875 no 1827 0.429869945138738 2713 6797406 SGTC_185 k048-0037 25.491 µM -0.176754770605744 0.455552049920889 no 1828 0.429850508697401 2719 6827589 SGTC_699 0375-0592 111 µM -0.176981466436678 0.455468548644141 no 1829 0.429761473704942 2745 762578 SGTC_1280 0880-0253 10.1 µM -0.177021677763837 0.45545373738537 no 1830 0.429745681042741 2761 6836607 SGTC_744 1594-0068 283 µM -0.178085146173337 0.455062046765559 no 1831 0.429328053602404 2765 668392 SGTC_503 tyrphostin 8 294 µM -0.178581219802282 0.454879350673745 no 1832 0.429133270926222 2816 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1365 1672-3266 55.4 µM -0.182357773856775 0.453488821039759 no 1833 0.427650980850548 2827 6415873 SGTC_1960 st011366 51.8 µM -0.182941649644111 0.453273888049002 no 1834 0.427421901314611 2711 3972846 SGTC_393 acivicin 6.25 µM -0.185513693283447 0.452327245951145 no 1835 0.426413070494607 2742 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_300 r073-0011 5.04 µM -0.186074199765501 0.452120986996749 no 1836 0.42619328708358 2751 2735780 SGTC_592 k241-0073 46.5 µM -0.186651822257725 0.451908443097507 no 1837 0.425966816198245 2831 4230158 SGTC_2333 9017922 200 µM -0.187140742154036 0.451728549269626 no 1838 0.425775142389996 2873 3163164 SGTC_1067 clotrimazole 1.36 µM -0.187459430891376 0.451611295851157 no 1839 0.425650214625913 2744 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_314 1671-0008 2.74 µM -0.188970998948461 0.451055210480185 no 1840 0.425057773364762 2729 3913060 SGTC_933 2914-0560 114 µM -0.18910864929047 0.451004575542869 no 1841 0.425003831323796 2940 463887 SGTC_1759 st043059 70 µM -0.19130898409813 0.450195287030399 no 1842 0.42414176139742 2759 669426 SGTC_3262 9137218 49.47 µM -0.191506459652228 0.450122665115401 no 1843 0.424064410064655 2688 17650664 SGTC_2502 avocadyne acetate 18.59 µM -0.193475833621533 0.44939851682094 no 1844 0.423293165228661 2695 3952079 SGTC_2817 7995342 71.43 µM -0.194019222244963 0.449198739764309 no 1845 0.423080415357145 2733 18879975 SGTC_1135 dihydrocapsaicin 536.708 nM -0.194582503024762 0.448991662942055 no 1846 0.422859900898227 2724 107982 A Capsaicinoid. SGTC_2667 digitoxin 100 µM -0.195278644431009 0.44873576226252 no 1847 0.422587407253241 2835 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1756 st041558 35.5 µM -0.196034432645827 0.448457959641826 no 1848 0.422291607741046 2912 3955792 SGTC_1568 digitonin 820 nM -0.19610445215085 0.448432224076688 no 1849 0.422264205804167 2860 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3117 9124945 49.47 µM -0.196180527194818 0.44840426305318 no 1850 0.422234434475588 2727 17592065 SGTC_3055 9094636 49.47 µM -0.196532666647559 0.448274839199867 no 1851 0.422096633453607 2919 25236176 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.1969563711695 0.448119119920574 no 1852 0.421930839862627 2879 688662 SGTC_977 1348-1378 135 µM -0.197316759491191 0.447986676811124 no 1853 0.421789832490957 2740 X977 SGTC_2772 vinpocetine 57.06 µM -0.197585454056175 0.447887935031465 no 1854 0.421684708209571 2938 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1140 3229-1848 2.98 µM -0.199241772877899 0.447279330805042 no 1855 0.421036812191464 2862 2849525 SGTC_2336 9001819 198.65 µM -0.202768654463808 0.445983815021383 no 1856 0.419657929539694 2993 2989602 SGTC_258 haloperidol 50.781 µM -0.203457939018067 0.445730689696946 no 1857 0.419388558940416 2791 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1857 st056007 79.3 µM -0.204353420326362 0.445401875979127 no 1858 0.419038663621818 2847 619834 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.204444730658671 0.445368349646935 no 1859 0.419002989129754 2925 688751 SGTC_1494 4358-1428 177 µM -0.204538575075264 0.445333893284434 no 1860 0.418966325277525 2899 1564571 SGTC_180 1486-1293 102.781 µM -0.20710538232093 0.444391613114552 no 1861 0.417963779372021 2841 4140536 SGTC_3096 9117468 49.47 µM -0.20870741633903 0.443803662074018 no 1862 0.417338325118603 2924 41316311 SGTC_3132 9126706 49.47 µM -0.209888288750931 0.443370357644134 no 1863 0.416877431436402 2986 850858 SGTC_3259 9138485 49.47 µM -0.210249360946871 0.443237880800813 no 1864 0.416736527982308 3064 17646153 SGTC_2931 9014674 55.67 µM -0.210273192761639 0.443229137167007 no 1865 0.416727228320754 2805 2996810 SGTC_1518 st038567 90.8 µM -0.211526083099846 0.442769504348771 no 1866 0.416238390633075 2743 77966 SGTC_3332 9141069 11.198 µM -0.211767012968286 0.442681126113673 no 1867 0.41614440234095 2761 17332883 SGTC_2225 6654152 15.4 µM -0.211897539406281 0.442633247411949 no 1868 0.416093485139841 2799 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3074 9116018 49.47 µM -0.211901542226237 0.442631779141628 no 1869 0.416091923697673 2746 17027303 SGTC_406 estrone 100 µM -0.21250911522434 0.44240892505558 no 1870 0.41585493363021 2967 5870 A steroid. SGTC_1104 tacrolimus 29.8 µM -0.216422475147224 0.440973968103204 no 1871 0.414329224371365 2793 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2396 5342950 42.78 µM -0.217224933224394 0.440679816607414 no 1872 0.414016527332381 2880 1886677 SGTC_2412 st077135 33.4 µM -0.219841217028212 0.439721011722163 no 1873 0.412997409117534 3072 13258915 SGTC_1381 2324-0066 62.1 µM -0.220725739857475 0.439396935115246 no 1874 0.412652994107768 2912 10885928 SGTC_3206 9114350 49.47 µM -0.221023289872775 0.43928792613194 no 1875 0.412537149347978 2912 17087243 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.221118226987256 0.439253146398621 no 1876 0.412500189207562 2768 6708784 An antioxidant flavonoid SGTC_2519 cryptotanshinone 88.04 µM -0.22215358711168 0.438873877936402 no 1877 0.41209716171549 2929 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3075 9116269 49.47 µM -0.223269377743594 0.438465209366394 no 1878 0.411662929376209 3001 17015205 YNL244C SUI1 SGTC_345 1362-0200 395 µM -0.223608605964 0.438340976898451 no 1879 0.411530933316942 2819 1419823 SGTC_918 glabranin 770.725 nM -0.224634550984781 0.437965291401321 no 1880 0.411131791963877 2852 124049 Also referred to as licorice root. SGTC_1194 1488-0194 225 µM -0.225096407894589 0.437796184638593 no 1881 0.410952137683313 2789 1391452 SGTC_213 1246-0773 967 nM -0.225788436899329 0.43754282270469 no 1882 0.410682985441542 2838 6251622 SGTC_50 0929-0078 56.389 µM -0.225921868768586 0.437493974288473 no 1883 0.410631094346516 2839 1377751 SGTC_1326 1431-2094 10.8 µM -0.226130709779018 0.43741752105856 no 1884 0.410549880092796 2766 616278 SGTC_2234 tolnaftate 200 µM -0.226569111478106 0.437257037072539 no 1885 0.410379406580857 2841 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2873 9040596 71.43 µM -0.227237128347207 0.437012518621529 no 1886 0.410119679247567 2908 6463863 SGTC_2851 9015922 71.43 µM -0.227284505564354 0.436995177750893 no 1887 0.410101260312974 3010 2996893 SGTC_3087 9117406 49.47 µM -0.228001629018467 0.436732713121106 no 1888 0.409822487050899 2935 42546093 SGTC_1404 3909-7820 48.3 µM -0.22828133135863 0.436630350603709 no 1889 0.409713768421498 2894 23741373 SGTC_2233 sulbentine 40.3845 µM -0.228631708145563 0.436502129384071 no 1890 0.409577588851729 2824 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2717 st081029 62.2815 µM -0.229901828993898 0.436037381659034 no 1891 0.409084027530669 2908 5292846 SGTC_1878 temozolomide 1 mM -0.2304646008038 0.43583148699108 no 1892 0.40886538381563 2859 5394 DNA alkylating agent. SGTC_2486 5283202 22.39 µM -0.23159795269091 0.43541689376885 no 1893 0.408425148900045 2878 1377751 SGTC_2682 pyrogallin 40.03 µM -0.231808699484799 0.435339807968188 no 1894 0.408343299937121 2852 822798 An ATP competetive kinase inhibitor. SGTC_2855 9016525 58.44 µM -0.231947243435758 0.435289133463842 no 1895 0.408289494991986 2776 43811474 SGTC_1220 1838-0075 193 µM -0.232561419019045 0.435064502446361 no 1896 0.408050994525016 2835 5529645 SGTC_2297 7971671 152.32 µM -0.232561951364981 0.435064307753123 no 1897 0.408050787815908 2975 909016 SGTC_702 1488-0190 94 µM -0.233110747047109 0.43486360678258 no 1898 0.407837704918286 2895 949357 SGTC_641 4092-0595 30 µM -0.234373353129265 0.43440192084234 no 1899 0.407347571853954 2874 786260 SGTC_1118 chelidonine 707.474 nM -0.234679198154284 0.434290098645894 no 1900 0.407228867177795 2937 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2740 felodipine 17.08 µM -0.236602043670311 0.433587194068512 no 1901 0.406482767298524 2924 3333 L-type calcium channel blocker SGTC_3182 9108849 49.47 µM -0.236764319662669 0.433527882948759 no 1902 0.406419816682668 2912 17133045 SGTC_176 1486-1328 72.834 µM -0.237132249655933 0.433393411795609 no 1903 0.406277097077685 2895 22310231 SGTC_2284 7945075 39.21 µM -0.238053777189714 0.433056645537509 no 1904 0.405919692336157 2973 1245402 SGTC_1569 carminic acid 40.6 µM -0.238482394615181 0.432900026627738 no 1905 0.4057534842793 2963 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2694 st077685 81.9 µM -0.239235008788705 0.432625043233031 no 1906 0.405461678799394 2797 2838096 SGTC_1201 1889-3372 45.9 µM -0.239894621991087 0.432384066520168 no 1907 0.405205975085772 2859 5392199 SGTC_645 0845-0943 5.41 µM -0.24009924352921 0.432309317171737 no 1908 0.405126660319527 2879 1885106 SGTC_1167 k781-0610 148 µM -0.245673579315834 0.43027392318196 no 1909 0.402967463061395 2892 4525169 SGTC_1983 st071813 46.9 µM -0.245952239001968 0.430172222472041 no 1910 0.402859602343581 2896 11838595 SGTC_227 fluconazole 33.516 µM -0.246657357743275 0.42991490033223 no 1911 0.402586705288487 2870 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_414 piperonyl butoxide 100 µM -0.247828171478746 0.429487695833072 no 1912 0.402133678523638 2842 5794 A potent inhibitor of cytochrome P450. SGTC_2317 5986382 200 µM -0.248192981167898 0.429354601549042 no 1913 0.401992548353547 2905 877883 SGTC_1051 3253-3903 78 µM -0.249413527348678 0.428909365587564 no 1914 0.401520461204851 2794 5509239 SGTC_596 1155-0152 116 µM -0.251242366147518 0.428242403548742 no 1915 0.400813365655767 2876 280313 SGTC_421 streptovitacin 30 mM -0.251353682773905 0.428201813913984 no 1916 0.40077033706706 3047 91467 include heat shock SGTC_674 0498-0004 451 µM -0.251877952363159 0.428010658521151 no 1917 0.400567700871412 2904 4231473 SGTC_1453 4237-0541 195 µM -0.252507128466717 0.427781275178038 no 1918 0.400324552435553 2985 739892 SGTC_976 1348-1067 47.6 µM -0.252619593878225 0.427740275407741 no 1919 0.400281093648641 2878 5310671 YGL099W LSG1 SGTC_823 0417-1665 178 µM -0.253206717744813 0.427526249446934 no 1920 0.400054237811953 2959 3429856 SGTC_874 0599-0792 117 µM -0.254538828281825 0.427040730520911 no 1921 0.399539655493955 3019 765305 SGTC_2257 7960413 200 µM -0.2549218424819 0.426901152434831 no 1922 0.399391732806738 2856 2974689 YIL048W NEO1 SGTC_2733 amorolfine 100 µM -0.254988937705508 0.426876702526021 no 1923 0.399365821661365 2886 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2923 7992654 58.14 µM -0.255223988793268 0.426791050692344 no 1924 0.399275052037012 2893 2985126 SGTC_868 0527-0199 213 µM -0.256380507980822 0.426369669302371 no 1925 0.398828518685858 2883 2849450 SGTC_1843 st055809 45.5 µM -0.257889254397409 0.425820079215302 no 1926 0.398246189090794 3010 16413835 SGTC_2963 9082507 9 µM -0.258561255954392 0.425575335951205 no 1927 0.397986890057218 3027 16459611 SGTC_2420 aureobasidin a 50 nM -0.258613255380056 0.425556398931367 no 1928 0.397966827395614 3140 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2472 5377652 49.4 µM -0.259244281586401 0.425326607095925 no 1929 0.397723383431093 2906 1610903 SGTC_2899 9053889 58.44 µM -0.259312036961317 0.42530193509165 no 1930 0.397697246411728 2949 6470052 SGTC_2627 acetyl isogambogic acid 100 µM -0.259388055708535 0.425274254464612 no 1931 0.397667922296375 2953 6857789 A caspase activator and apoptosis inducer. SGTC_2942 9052777 62.25 µM -0.260548127453241 0.424851884531926 no 1932 0.397220498229094 2896 6469503 SGTC_293 4049-0273 38.5 µM -0.260637116927132 0.424819487955655 no 1933 0.397186181762968 2910 1380311 SGTC_2614 arthonioic acid 13.39 µM -0.261955029284259 0.424339762140152 no 1934 0.396678056602331 2819 6710684 SGTC_2139 5578692 56.4705 µM -0.263338266708581 0.423836378262918 no 1935 0.396144933823426 2963 650991 YMR113W FOL3 SGTC_1508 1080-0625 72.9 µM -0.265169371887187 0.423170198851069 no 1936 0.395439494133106 2842 767111 SGTC_2553 4-methylesculetin 85.09 µM -0.266329168853309 0.422748363400029 no 1937 0.394992855287253 2930 5319502 SGTC_2354 9060492 162 µM -0.266907721877665 0.422537968118274 no 1938 0.394770105534379 3019 6471895 SGTC_798 1287-0182 476 µM -0.267154165047975 0.422448353861167 no 1939 0.394675232442596 3061 1649755 SGTC_1315 1237-0019 3.69 µM -0.268346709408021 0.422014765130647 no 1940 0.394216227634693 2995 825140 SGTC_886 0866-0150 153 µM -0.268992735018475 0.421779920700769 no 1941 0.393967636656365 3062 271463 SGTC_901 1112-0062 60.1 µM -0.269379308500864 0.42163940608698 no 1942 0.393818903637885 2886 1908457 SGTC_1351 1496-0003 46.5 µM -0.270786297910207 0.421128067446413 no 1943 0.393277699490272 3014 3891978 SGTC_2617 dihydrotanshinone i 20.83 µM -0.270923895970173 0.421078067653906 no 1944 0.393224782892318 2884 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3121 9125696 49.47 µM -0.27247786713673 0.4205134808272 no 1945 0.392627303576395 2898 1235365 SGTC_3296 9122258 64.045 µM -0.272722426929604 0.420424642533602 no 1946 0.392533296893436 2980 4730474 SGTC_3108 9121785 49.47 µM -0.273547549342105 0.420124940175189 no 1947 0.392216173220326 2814 17140271 SGTC_705 1124-0212 310 µM -0.274936897583435 0.419620403478283 no 1948 0.391682359457764 3024 9554485 SGTC_2536 dehydroabietamide 32.04 µM -0.275272217635749 0.419498652994445 no 1949 0.3915535536815 3050 3983547 SGTC_1072 oxiconazole 14.9 nM -0.276718761420946 0.418973519652921 no 1950 0.390998032341135 2895 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_694 1315-0438 43.2 µM -0.277052317045706 0.418852450653979 no 1951 0.390869967295492 2929 6793154 SGTC_3136 9095672 49.47 µM -0.277475794587513 0.418698754224439 no 1952 0.39070739476165 2798 17217380 SGTC_1166 k206-0078 225 µM -0.277718620086029 0.418610629026655 no 1953 0.390614182951497 2888 5404595 SGTC_1278 0874-0585 172 µM -0.279241836389381 0.418057923184194 no 1954 0.390029619620249 2961 766306 SGTC_1397 3532-0190 20.1 µM -0.279927557075617 0.417809159114341 no 1955 0.389766542287638 2847 5322280 SGTC_1788 fluconazole 20 µM -0.281752151162151 0.417147397762068 no 1956 0.389066781426219 3005 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1090 efavirenz 20.7 µM -0.284235830603047 0.416246970418167 no 1957 0.388114829233231 2946 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1856 st057054 55.7 µM -0.285730855117549 0.415705179254331 no 1958 0.387542135250943 3147 1266018 SGTC_1444 4112-3581 28 µM -0.286161364845 0.415549193837864 no 1959 0.387377266651419 2923 2877249 SGTC_842 0271-0008 11.1 µM -0.286782544800678 0.415324146855658 no 1960 0.387139414519711 3029 1221709 SGTC_1464 k208-0027 110 µM -0.288488476768663 0.414706248694437 no 1961 0.386486424979427 3104 X1464 SGTC_2921 7974240 10.71 µM -0.288998915637888 0.414521405801436 no 1962 0.386291103682464 3037 2979074 YDR527W RBA50 SGTC_385 1494-0393 12.4 µM -0.290590419751508 0.413945203381984 no 1963 0.385682293990093 2955 3090647 SGTC_2243 6634756 200 µM -0.290731098614744 0.413894279636158 no 1964 0.385628492597328 3178 885676 SGTC_1717 st033143 58.0435 µM -0.291194840047011 0.413726422097033 no 1965 0.385451154356757 3087 674616 SGTC_2068 5226020 147 µM -0.291321007173541 0.413680756910474 no 1966 0.385402911232931 2967 1810509 SGTC_2022 5136654 200 µM -0.292837385958992 0.413132007187452 no 1967 0.384823225194402 3072 1713771 SGTC_137 0438-0332 85.389 µM -0.292939177686947 0.413095176689918 no 1968 0.384784321137466 2983 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2107 5363541 170.161 µM -0.294272972086628 0.412612651177383 no 1969 0.384274661957945 3000 244052 SGTC_429 1112-0049 25.5 µM -0.295339045930477 0.412227073572665 no 1970 0.3838674458565 2897 2836170 SGTC_1734 st037168 69.4 µM -0.295484483453918 0.412174478284884 no 1971 0.383811901939071 3007 708907 SGTC_1323 1348-1351 11.2 µM -0.297350011604375 0.411499978352758 no 1972 0.383099651760001 2945 6989654 SGTC_3187 9109394 49.47 µM -0.298148509420947 0.411211353457098 no 1973 0.382794909501652 2969 17098090 SGTC_3241 9133421 49.47 µM -0.300803542639145 0.410252011915377 no 1974 0.381782153407497 2977 17018221 SGTC_3287 9117173 37.0625 µM -0.303316600936538 0.409344464492087 no 1975 0.380824298014532 3001 2789709 SGTC_2661 dactinomycin 12.96 µM -0.303625092810896 0.409233091371007 no 1976 0.38070676612588 2970 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1448 4255-0083 152 µM -0.304559811660003 0.408895679741348 no 1977 0.380350716146707 3098 5399660 SGTC_3202 9113761 49.47 µM -0.305418038176428 0.408585939488473 no 1978 0.380023892608542 3095 4798415 SGTC_396 dithiazanine 1.25 µM -0.305916619445034 0.408406024052297 no 1979 0.379834065860861 2956 10578 An antihelmenthic. SGTC_271 rotenone 740 µM -0.307616024844007 0.407792930741032 no 1980 0.379187262532785 3062 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_89 0302-0250 142.109 µM -0.308408336605412 0.407507166037827 no 1981 0.378885819623124 2930 4203518 YLR208W SEC13 SGTC_2867 9039098 71.43 µM -0.308725970359667 0.407392618232737 no 1982 0.378764993366051 2916 6463460 SGTC_1591 genipin 88.4 µM -0.309792628186145 0.407008008949827 no 1983 0.37835932894072 3078 442424 A DNA cross-linking agent. SGTC_2150 5556613 200 µM -0.310107412949496 0.406894522805603 no 1984 0.378239637623778 2976 743190 SGTC_2220 6782180 200 µM -0.310767615831688 0.406656531987333 no 1985 0.377988645160912 3014 833803 SGTC_845 0330-0138 4.51 µM -0.312949463428593 0.405870262310533 no 1986 0.377159528614732 3027 9039800 SGTC_2428 5615643 7.78 µM -0.313043401098219 0.405836418610759 no 1987 0.377123844359685 3073 2253075 SGTC_1644 st010134 20.9 µM -0.313148985441375 0.405798379707835 no 1988 0.377083737116423 3061 3818134 SGTC_751 0833-0568 350 µM -0.313160884994324 0.405794092708094 no 1989 0.377079217038234 3048 6954252 SGTC_1853 st056710 91.2 µM -0.313657487094613 0.40561519412806 no 1990 0.376890596379597 3122 269167 SGTC_1050 3232-1156 69.3 µM -0.313899348107563 0.405528071967363 no 1991 0.376798742756982 3007 700529 SGTC_716 1683-5115 658 µM -0.314820341229976 0.405196358561071 no 1992 0.376449033208779 2943 723597 SGTC_2534 helenine 20.12 µM -0.315349272920406 0.40500588439556 no 1993 0.376248238802075 2908 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1221 2958-7315 257 µM -0.315700362528307 0.404879465557889 no 1994 0.376114975752547 3039 4562705 SGTC_256 clotrimazole 625 nM -0.316575974109132 0.404564222379649 no 1995 0.375782684331203 3031 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1630 st005209 31.3 µM -0.316656077874115 0.404535386008783 no 1996 0.37575228983734 3014 3367314 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.316707646266723 0.404516822295606 no 1997 0.375732723185033 3060 7104 SGTC_391 gliotoxin 8.33 µM -0.316881704458758 0.404454165999146 no 1998 0.375666682452399 3124 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2421 5690543 90.72 µM -0.317511916788248 0.404227326914745 no 1999 0.375427599317284 3061 3397993 SGTC_2305 7443522 69.23 µM -0.317970816287111 0.404062170548305 no 2000 0.375253537083575 2956 5415886 SGTC_346 4513-0042 7.16 µM -0.319630376306517 0.40346504348811 no 2001 0.374624272222241 2948 2827372 SGTC_483 fpl-64176 144 µM -0.319705032520042 0.403438186678967 no 2002 0.374595972230809 2976 3423 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.32013070801721 0.403285062977358 no 2003 0.374434623984364 3018 6857784 SGTC_2321 7390090 138.78 µM -0.321599174797591 0.402756941043619 no 2004 0.373878184534342 3026 649046 SGTC_1247 0448-0043 5.84 µM -0.321707280599547 0.402718068684398 no 2005 0.373837230862931 3090 3089013 YGL099W LSG1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.321853819535007 0.402665378189954 no 2006 0.373781719859063 3009 1241132 A phosphatase inhibitor. SGTC_1435 4092-0789 56.7 µM -0.321894009914597 0.402650927384093 no 2007 0.373766495637071 3081 2248285 SGTC_2006 4011487 200 µM -0.322317194628288 0.402498775660574 no 2008 0.373606204108685 3132 45595294 SGTC_1312 1218-2183 165 µM -0.323521640792038 0.402065810302076 no 2009 0.373150110503668 2995 6744073 SGTC_926 2268-1401 59.4 µM -0.32368460345217 0.402007238911711 no 2010 0.373088414258604 2947 2931578 SGTC_2662 daunorubicin 22.37 µM -0.324238976893796 0.401808004700728 no 2011 0.372878557671976 2971 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2618 avocadyne 43.43 µM -0.324708109151728 0.401639424932595 no 2012 0.372700998370298 2927 3015189 SGTC_2565 isoliquiritigenin 100 µM -0.327178790280409 0.400751903707434 no 2013 0.371766330894223 3119 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2522 biochanin a 4.94 µM -0.329122845936019 0.400053917284884 no 2014 0.371031418382391 3117 5280373 A possible chelator. SGTC_1335 1486-0900 202 µM -0.332851511203479 0.398716086232116 no 2015 0.369623186367795 2952 X1335 SGTC_3125 9127534 49.47 µM -0.333682690634588 0.398418023722459 no 2016 0.369309506274818 3058 1639235 SGTC_105 0111-0055 734.78 µM -0.333742469582245 0.398396589161158 no 2017 0.36928694955593 3075 5179370 SGTC_2890 9046729 58.44 µM -0.33722899427136 0.397146980279873 no 2018 0.367972140923797 3006 903329 SGTC_58 0957-0393 9 µM -0.338161822865601 0.396812822612918 no 2019 0.367620621907741 3125 6997992 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.339353404652101 0.396386084649232 no 2020 0.367171757888324 2974 16486 A toxic proline analog. SGTC_2217 6934799 96.0675 µM -0.340564135223375 0.395952616087966 no 2021 0.366715866469544 3075 675606 SGTC_2955 9076254 12.21 µM -0.340729283993739 0.395893499100763 no 2022 0.366653695505071 3112 16459619 SGTC_1088 bifonazole 369 nM -0.341082217320809 0.395767170402792 no 2023 0.366520843965526 3082 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_36 0335-0881 14.2 µM -0.342617880550657 0.395217623849612 no 2024 0.365942974335117 3019 23828853 SGTC_499 genistein 192 µM -0.3466366411672 0.393780474165634 no 2025 0.364432157507405 3085 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1834 st055981 52.8 µM -0.348337452459986 0.393172680936476 no 2026 0.363793384995731 3176 471719 YDL150W RPC53 SGTC_368 fentichlor 4.58 µM -0.348527392146622 0.3931048211915 no 2027 0.363722072934701 3071 7329 A pesticide. SGTC_1030 k029-0042 36.7 µM -0.349759954883654 0.392664542559396 no 2028 0.3632594272202 3065 6080581 SGTC_985 1493-0307 8.71 µM -0.349800580704173 0.392650033112777 no 2029 0.363244181601145 3169 3278274 SGTC_2436 5633522 8.09 µM -0.349983321671651 0.392584769314547 no 2030 0.363175607224363 3198 5724242 SGTC_1477 0139-0234 16 µM -0.350542366954014 0.392385131594368 no 2031 0.362965850185903 3051 620880 SGTC_1964 st076914 61 µM -0.354135248577555 0.391102774478413 no 2032 0.361618763514817 3024 24208661 SGTC_1 0258-0098 57.368 µM -0.354248874964283 0.391062238622703 no 2033 0.361576189196509 3068 6790032 YDR047W HEM12 SGTC_894 0960-0238 55.9 µM -0.354302043429744 0.391043271346459 no 2034 0.361556268257655 3139 6741907 YDL195W SEC31 SGTC_2216 7189485 200 µM -0.356766799385013 0.390164281440701 no 2035 0.36063319651341 3138 731273 SGTC_1208 2323-2347 50.3 µM -0.357268141138272 0.389985559732269 no 2036 0.360445538968639 3195 5412760 SGTC_2727 riluzole 51.77 µM -0.357796980811063 0.389797060581591 no 2037 0.360247625085891 3074 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_575 k072-0246 11.9 µM -0.358305018429442 0.38961600050393 no 2038 0.36005753146449 3062 6796779 SGTC_1055 3448-0672 86 µM -0.358514350630779 0.389541403340319 no 2039 0.359979215209181 3176 748378 SGTC_2063 5246145 200 µM -0.358593158116565 0.389513320732032 no 2040 0.359949732939384 3152 711240 SGTC_1041 0206-0046 107 µM -0.35907412380885 0.38934194379854 no 2041 0.359769819362133 3094 50494 SGTC_1996 st072960 66.8 µM -0.359100964979814 0.389332380428738 no 2042 0.359759779870557 3156 1719405 SGTC_3034 9090421 49.47 µM -0.35980978830816 0.389079854632708 no 2043 0.359494691385568 3085 17173761 SGTC_2375 9072683 200 µM -0.360843633846136 0.388711620261064 no 2044 0.359108171073855 3209 16798029 SGTC_1966 st070145 16.1 µM -0.360961736512237 0.388669560893544 no 2045 0.359064025600629 2968 3748532 SGTC_2544 sphondin 68.51 µM -0.362940653980477 0.387965012480594 no 2046 0.358324608457004 3230 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2788 5282734 71.43 µM -0.365377704075848 0.387097863104327 no 2047 0.357414741026724 3198 743706 SGTC_1614 st002383 48.6 µM -0.368470965009784 0.38599803274337 no 2048 0.356261045558356 3134 1947235 SGTC_1283 0922-0125 16.4 µM -0.369362350953328 0.3856812638502 no 2049 0.35592882828943 3143 3360884 SGTC_1469 k284-2957 126 µM -0.369487890037109 0.385636657557501 no 2050 0.355882048973354 3084 23884841 SGTC_2161 5662504 8.5105 µM -0.370457634021462 0.385292141098503 no 2051 0.355520768853158 3076 2859334 SGTC_2426 5582046 32.21 µM -0.370688246315022 0.385210225846561 no 2052 0.355434872855875 3220 2251934 SGTC_3327 9140648 26.9345 µM -0.371154830525676 0.385044507230781 no 2053 0.355261107026431 3182 8029710 SGTC_1651 st011928 86.1 µM -0.371620760453149 0.384879041949131 no 2054 0.355087614891896 3154 720198 SGTC_2366 9070441 60.58 µM -0.373370687437046 0.384257779384534 no 2055 0.354436286363202 3057 6837235 SGTC_3279 9140807 49.47 µM -0.374000734008536 0.384034171683779 no 2056 0.354201885043686 3094 45595718 SGTC_2363 9053361 176 µM -0.374468228669718 0.383868279673067 no 2057 0.354027994913479 3225 6469797 YMR079W SEC14 SGTC_551 k048-0028 34.9 µM -0.375550085483669 0.383484460887534 no 2058 0.353625702344687 3206 6836383 SGTC_775 4577-0580 57.3 µM -0.37621460102843 0.383248762168136 no 2059 0.353378680702233 3273 2006902 SGTC_1798 st045719 60.953 µM -0.37773386037398 0.382710054633601 no 2060 0.35281415561653 3164 3980186 SGTC_1486 3970-0793 4.53 µM -0.37859759183473 0.382403888942056 no 2061 0.352493355354392 3157 2844330 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.379463746717453 0.382096938028185 no 2062 0.352171760332857 3134 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_581 0958-0271 211 µM -0.379843300572359 0.381962453777721 no 2063 0.352030868907675 3074 4591145 SGTC_10 0279-0212 42.575 µM -0.380526659336344 0.381720360702884 no 2064 0.351777255487707 3085 39851 YBR002C RER2 SGTC_279 1273-0055 2.93 µM -0.380956297359877 0.381568176790295 no 2065 0.351617838637339 3139 2847562 SGTC_3081 9117243 49.47 µM -0.381861998413506 0.381247424562117 no 2066 0.351281864475656 3237 45595589 SGTC_2214 7179297 48.276 µM -0.382760843021288 0.38092918116198 no 2067 0.350948548606536 3104 769744 SGTC_2084 5306078 60.6385 µM -0.382789213791122 0.380919137565159 no 2068 0.350938029823816 3092 679340 SGTC_215 1287-0124 461.5 µM -0.382835592257744 0.380902719197926 no 2069 0.350920834730534 3110 5560863 SGTC_2109 5483026 200 µM -0.383953547994189 0.380507018413273 no 2070 0.350506438420986 3120 759335 SGTC_1165 k072-0275 30.3 µM -0.384234714441199 0.380407519115538 no 2071 0.350402245504685 3218 6153523 YGL055W OLE1 SGTC_786 4544-0069 423 µM -0.384591137667719 0.380281399290317 no 2072 0.350270180577178 3162 748821 YLR208W SEC13 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.384593640098252 0.380280513853994 no 2073 0.350269253419575 3026 688667 SGTC_2967 9089538 49.85 µM -0.38607012341363 0.37975819850929 no 2074 0.3497223679174 3280 728216 SGTC_447 ml7 120 µM -0.386153233851874 0.379728804174989 no 2075 0.349691593287163 3161 4216 Selective myosin light chain kinase inhibitor. SGTC_2922 7999257 32.47 µM -0.387328836495931 0.379313093887436 no 2076 0.349256389983202 3134 2988377 SGTC_1682 st012968 530 nM -0.389301898012283 0.378615704244312 no 2077 0.348526416213592 3074 24207270 SGTC_1017 4239-0030 168 µM -0.389989499333253 0.378372760427568 no 2078 0.348272155859165 3106 1149593 SGTC_2616 abietic acid 100 µM -0.390326399512122 0.37825374414319 no 2079 0.348147602211084 3252 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2980 9014342 25.29 µM -0.391313609371395 0.377905060361739 no 2080 0.347782720239902 3238 2996599 SGTC_785 1270-0111 65.3 µM -0.394016976465078 0.376950737448585 no 2081 0.346784252803422 3065 6741994 SGTC_819 1013-0258 27.7 µM -0.39455375062479 0.376761338559788 no 2082 0.34658612576571 3111 5753198 SGTC_2365 9042475 200 µM -0.394679173031686 0.376717087973972 no 2083 0.346539837537156 3211 6464479 SGTC_745 0469-0705 296 µM -0.395047705795774 0.37658707440257 no 2084 0.346403840579698 3318 3486736 SGTC_2716 st080858 38.6235 µM -0.395381841487864 0.376469207769803 no 2085 0.346280554034907 3230 5296050 SGTC_1329 1447-1697 50.6 µM -0.395910196917914 0.376282853476914 no 2086 0.346085639185998 3180 2840515 SGTC_1998 st075797 76.8 µM -0.396596341618885 0.376040888959704 no 2087 0.345832575377761 3218 24208315 SGTC_986 1493-0483 84 µM -0.397835208984594 0.375604133808753 no 2088 0.34537583092357 3217 40079 SGTC_2583 asiatic acid 100 µM -0.397883590312476 0.375587080495735 no 2089 0.345357998303516 3273 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3149 9097855 49.47 µM -0.397952189443109 0.375562901285687 no 2090 0.34533271429795 3238 25236625 YMR079W SEC14 SGTC_1985 st071382 65.5 µM -0.397970497406163 0.375556448340694 no 2091 0.345325966535533 3121 6123237 SGTC_1650 st011916 45.8 µM -0.398216739445356 0.375469659636744 no 2092 0.345235213932932 3252 242528 SGTC_2726 cimetidine 79.27 µM -0.399067953920378 0.3751696952552 no 2093 0.344921567072412 3113 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_21 0849-0113 22.993 µM -0.400599917483912 0.374630028034506 no 2094 0.344357353212992 3128 1560156 SGTC_17 0960-0276 49.807 µM -0.400696510642782 0.374596009225588 no 2095 0.344321790066516 3112 6821114 SGTC_165 k038-0023 64.381 µM -0.40215843345493 0.374081259024314 no 2096 0.343783715458431 3114 46368543 SGTC_1965 Pectolinarigenin 58.4 µM -0.403001824053834 0.373784399079853 no 2097 0.343473441309981 3120 5320438 An anti-inflammatory. SGTC_1648 st011736 69.8 µM -0.403050416815142 0.373767297487488 no 2098 0.343455567776979 3251 2855514 SGTC_2185 6113692 200 µM -0.404320320851177 0.37332045943202 no 2099 0.342988592140295 3232 874150 SGTC_2261 9010538 184.68 µM -0.40456841923304 0.373233181522661 no 2100 0.34289738809896 3211 6457250 SGTC_1845 st056753 3.01 µM -0.405265587851283 0.372987961147824 no 2101 0.342641149288886 3066 5375839 SGTC_3172 9105863 49.47 µM -0.405992947207785 0.372732176397757 no 2102 0.342373891270439 3149 2348785 SGTC_260 nsc-65238 3.989 µM -0.40646471746404 0.372566302648954 no 2103 0.342200588072664 3223 3246252 SGTC_2228 7354201 200 µM -0.409663814318755 0.371442129659335 no 2104 0.341026289011507 3156 753451 SGTC_940 3232-1287 54.8 µM -0.410081504685893 0.371295432579271 no 2105 0.340873079847652 3226 1585493 YIL048W NEO1 SGTC_3293 9120939 62.045 µM -0.411442194685397 0.370817674248966 no 2106 0.340374159750623 3252 934087 SGTC_2904 7225135 42.03 µM -0.411689765242909 0.370730769960547 no 2107 0.340283413803805 3242 4446116 SGTC_3247 9135149 49.47 µM -0.412910445364872 0.370302373107157 no 2108 0.339836113948811 3150 8934436 YOR116C RPO31 SGTC_1481 3346-2004 36 µM -0.413296653988204 0.370166866919819 no 2109 0.339694640524034 3226 2770522 SGTC_1612 st002233 45.4 µM -0.413543148096862 0.370080389762413 no 2110 0.339604358212955 3215 1035021 SGTC_2431 5490079 200 µM -0.41468610104153 0.369679495193485 no 2111 0.339185854209855 3187 5722345 SGTC_1641 st009299 47.1 µM -0.415449915600545 0.369411663595235 no 2112 0.338906286153323 3226 4046054 SGTC_329 k048-0121 21.3 µM -0.415747080995634 0.369307479654904 no 2113 0.338797542938294 3200 6832902 SGTC_3208 9114115 49.47 µM -0.415867024530072 0.369265431077114 no 2114 0.338753655207536 3192 650895 SGTC_508 roscovitine 141 µM -0.416871906813 0.36891321121007 no 2115 0.338386051547038 3157 160355 A CDKinase inhibitor. SGTC_83 0170-0301 39.027 µM -0.417009626838744 0.368864947727791 no 2116 0.33833568312207 3199 3089716 SGTC_591 4299-0174 154 µM -0.417051201445559 0.368850378464307 no 2117 0.338320478585356 3164 5509088 SGTC_857 0438-0306 1.35 µM -0.418958884160679 0.368182059677418 no 2118 0.337623090688054 3234 4686136 SGTC_984 1492-0255 2.91 µM -0.420949675272331 0.367485050647009 no 2119 0.336895915142174 3224 1585198 SGTC_1743 st037606 46.3785 µM -0.421258869039473 0.367376835862604 no 2120 0.336783030636992 3134 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1305 1181-0477 144 µM -0.421481442537318 0.367298943841373 no 2121 0.336701779693328 3272 6252086 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.421764289837929 0.367199966224998 no 2122 0.336598536663524 3329 94937 An inhibitor of serotonin biosynthesis. SGTC_1952 st077036 64.1 µM -0.422656630355613 0.366887764655176 no 2123 0.336272901244421 3202 2937007 SGTC_3276 9139060 49.47 µM -0.423697138321658 0.366523835174036 no 2124 0.335893351224167 3168 4870619 SGTC_704 1310-0270 142 µM -0.424594802495274 0.366209963320869 no 2125 0.335566041279814 3186 5718033 SGTC_1852 st056254 31.4 µM -0.424902155057032 0.366102516829349 no 2126 0.335454001797845 3134 442583 SGTC_1711 st032263 62.8 µM -0.425054442489699 0.366049282996171 no 2127 0.335398493754892 3175 3958979 SGTC_1246 0422-0085 105 µM -0.42518479337249 0.366003719385651 no 2128 0.335350984333604 3293 264295 SGTC_904 1141-0088 396 µM -0.425585624614691 0.365863622329049 no 2129 0.335204908532937 3176 1378119 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.426178153703716 0.365656556514273 no 2130 0.334989017515756 3216 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_543 3844-1095 191 µM -0.427232447106816 0.365288218885389 no 2131 0.334605015123023 3227 4230703 SGTC_1570 verbenone 133 µM -0.427264041560745 0.365277182672237 no 2132 0.334593510228768 3313 29025 A natural terpanoid with antifungal properties. SGTC_342 k048-0088 23.3 µM -0.42735527441502 0.365245314881682 no 2133 0.334560289309662 3126 6820570 SGTC_2358 9037157 4 µM -0.427875235416481 0.365063709392222 no 2134 0.334370978934255 3229 2388925 SGTC_2693 st077581 40.7 µM -0.430075972897009 0.36429539880109 no 2135 0.333570188670929 3275 25238761 SGTC_1629 st005085 44.9 µM -0.43072041787156 0.364070516379304 no 2136 0.33333583542122 3132 24207091 SGTC_2298 7976326 193.81 µM -0.430929701969638 0.363997495669171 no 2137 0.333259742974973 3175 2235818 SGTC_2945 9067681 61.76 µM -0.430969366421066 0.36398365701653 no 2138 0.333245322370173 3249 16456930 SGTC_1698 5-fluorocytosine 1.055 µM -0.431694946661357 0.363730538409683 no 2139 0.332981570335146 3281 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1718 roemerine 11.9335 µM -0.433175019946571 0.363214399422954 no 2140 0.332443812537921 3247 235224 An aporphine alkaloid with mutagenic activity. SGTC_1976 st070609 63.5 µM -0.434822343151299 0.362640228128885 no 2141 0.331845692840635 3158 682556 SGTC_1454 4239-0054 42.6 µM -0.436843998347917 0.361936006193961 no 2142 0.33111224395351 3342 1340767 SGTC_3228 9131799 49.47 µM -0.437632851841097 0.361661344112856 no 2143 0.330826226354902 3217 17015818 SGTC_2910 7948405 25.97 µM -0.43781125955079 0.361599236201736 no 2144 0.330761554079369 3300 2971328 SGTC_2481 5478948 45.16 µM -0.438134062042428 0.361486870345821 no 2145 0.330644551954877 3301 77792 SGTC_90 0870-0863 4.608 µM -0.438487083483952 0.361363999107224 no 2146 0.330516615693814 3148 1738164 SGTC_2184 6075246 200 µM -0.439639717742769 0.360962917428434 no 2147 0.330099034772562 3241 2267320 SGTC_518 1021-0119 62.6 µM -0.439727870363572 0.360932249282442 no 2148 0.330067107193403 3182 1097762 SGTC_318 1488-0629 67.2 µM -0.440052274593246 0.36081939730647 no 2149 0.32994962342463 3269 3662576 SGTC_3335 9143315 29.6265 µM -0.440351203797936 0.360715418170426 no 2150 0.329841380343418 3181 4899691 SGTC_2221 6807166 181.081 µM -0.440567260367918 0.360640271750746 no 2151 0.329763154539295 3227 674925 SGTC_1039 k821-0043 94 µM -0.440984598546837 0.360495133014131 no 2152 0.329612073462564 3290 15992768 SGTC_1233 0325-0408 14.2 µM -0.441530909046479 0.360305171628 no 2153 0.329414344988011 3283 12874 SGTC_2991 9074669 71.4286 µM -0.442225821460672 0.360063588676246 no 2154 0.329162901309881 3341 17333109 SGTC_82 0054-0107 293.755 µM -0.442584151509761 0.359939038791016 no 2155 0.329033275117788 3223 3104697 SGTC_634 1611-4317 11.2 µM -0.443063649687777 0.359772396034688 no 2156 0.328859848414589 3314 2843522 SGTC_958 1222-0007 33 µM -0.443405913192326 0.359653463534137 no 2157 0.328736079795345 3323 7312461 SGTC_1127 asiatic acid 681.4 nM -0.443493588892312 0.359622999456534 no 2158 0.328704377711805 3150 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.447447541704171 0.358250076315207 no 2159 0.32727597801742 3404 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_139 0099-0334 718.624 µM -0.448596602811714 0.35785143264213 no 2160 0.326861342445751 3220 97690 SGTC_2357 9067248 200 µM -0.448893713527952 0.357748381245984 no 2161 0.326754165602951 3279 9150235 SGTC_1378 2093-0007 380 nM -0.449095646791967 0.357678347600173 no 2162 0.326681330310752 3279 3618014 SGTC_207 4185-0010 4.486 µM -0.450046505814755 0.357348639104552 no 2163 0.326338453863237 3301 3761753 SGTC_442 cape 100 µM -0.450705561739417 0.357120175211683 no 2164 0.326100886656237 3308 5281787 SGTC_1021 4476-0760 85.3 µM -0.451449654202486 0.356862294685405 no 2165 0.325832751478029 3185 746768 SGTC_2332 7982454 138.89 µM -0.452636452240571 0.356451120821967 no 2166 0.32540527289266 3285 2981748 SGTC_3139 9095020 49.47 µM -0.45313563753894 0.356278224649683 no 2167 0.325225537462002 3187 25236292 SGTC_478 N-arachidonylglycine 10 µM -0.45328188735402 0.356227575640083 no 2168 0.325172886811348 3248 5283389 SGTC_2319 6033012 152.6 µM -0.453934825242309 0.356001482152258 no 2169 0.324937868556927 3168 847246 SGTC_3302 9125395 16.351 µM -0.453975779478113 0.355987302572639 no 2170 0.324923129822816 3197 17599668 SGTC_2025 5147754 141 µM -0.456359672178668 0.355162271561008 no 2171 0.324065680165402 3241 315777 YLR208W SEC13 SGTC_2540 epiandrosterone 100 µM -0.457390684162333 0.35480566307508 no 2172 0.323695129540495 3278 441302 A steroid. SGTC_2714 st079313 56.9 µM -0.458209583330962 0.354522511202631 no 2173 0.323400937743748 3212 2939799 SGTC_682 0kpi-0099 17 µM -0.460640816165341 0.353682334613494 no 2174 0.322528161459301 3303 1714895 YML126C ERG13 SGTC_1374 2889-5571 141 µM -0.460660933610546 0.353675385465611 no 2175 0.322520943666414 3244 2853281 SGTC_2459 5811157 9.22 µM -0.461432694323379 0.353408833811715 no 2176 0.322244099738732 3286 2870684 YBR192W RIM2 SGTC_899 1083-0020 478 µM -0.461789632246536 0.353285578459844 no 2177 0.322116093255674 3363 767123 SGTC_152 4469-0003 551.229 µM -0.462474812377574 0.353049019890899 no 2178 0.321870430391615 3346 697280 SGTC_38 0929-0051 58.268 µM -0.462650836308711 0.352988256759578 no 2179 0.32180733175007 3296 1379719 SGTC_928 2764-0428 58.7 µM -0.463246454765104 0.352782678196292 no 2180 0.321593860744274 3298 662578 SGTC_1500 4488-1866 171 µM -0.463392184984866 0.35273238574412 no 2181 0.321541639668046 3367 2900003 SGTC_1573 oleylamine 1.06 µM -0.466315955169265 0.351723918354475 no 2182 0.320494679929711 3257 5356789 An amine of the fatty acid oleic acid. SGTC_2681 menadione 3.18 µM -0.466659770040121 0.351605398026598 no 2183 0.320371658403936 3321 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_441 propafenone 146 µM -0.466922156356061 0.351514957563529 no 2184 0.320277786374198 3208 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3105 9121040 49.47 µM -0.467306121891172 0.351382625793373 no 2185 0.320140438566807 3248 41448907 SGTC_121 0557-0495 61.343 µM -0.467491435529727 0.351318764833388 no 2186 0.320074159083981 3264 3104427 SGTC_1980 st071811 45.7 µM -0.470042695688371 0.350440002065619 no 2187 0.319162256954426 3372 4974850 SGTC_2896 9052656 71.43 µM -0.470123245622646 0.350412270235929 no 2188 0.319133483600136 3293 6469436 SGTC_3295 9122362 53.5725 µM -0.471178613090881 0.350049000747356 no 2189 0.318756595028276 3306 4730473 SGTC_3036 9090181 49.47 µM -0.471742355648993 0.349855010334271 no 2190 0.318555350313821 3275 25236586 SGTC_31 0508-1974 57.237 µM -0.472305913443456 0.349661122667315 no 2191 0.318354225042101 3317 6810525 SGTC_1793 st048256 72.231 µM -0.472916342242719 0.349451153630171 no 2192 0.318136432607257 3287 672022 SGTC_2264 7948757 110.76 µM -0.473963396719384 0.349091105854014 no 2193 0.317763004681137 3148 2971411 SGTC_3184 9108758 49.47 µM -0.474168658459556 0.34902053896801 no 2194 0.317689820586407 3255 902885 SGTC_3192 9110362 49.47 µM -0.476346734371684 0.348272060811397 no 2195 0.316913687870112 3355 16649480 SGTC_1347 1493-0251 600 nM -0.477213764753692 0.347974276997017 no 2196 0.316604955199666 3342 3986378 SGTC_477 mead ethanolamide 10 µM -0.477278908145299 0.347951907115221 no 2197 0.316581764059907 3247 16061185 SGTC_3007 9078383 71.4286 µM -0.478758447675615 0.347443984019177 no 2198 0.316055240194796 3239 6496995 SGTC_3297 9117502 71.43 µM -0.480023987285029 0.347009743900205 no 2199 0.315605168305222 3329 7453720 SGTC_1733 st037357 54.9 µM -0.480416140114226 0.346875226621192 no 2200 0.315465759948922 3146 1272339 YGL099W LSG1 SGTC_3011 9081274 71.4286 µM -0.480769962328948 0.346753874168596 no 2201 0.315340000469273 3246 6625322 SGTC_1703 st026983 48.3 µM -0.48202149570299 0.346324754746382 no 2202 0.314895338101338 3368 1104023 SGTC_358 0075-0058 9.45 µM -0.482232646560898 0.34625237583621 no 2203 0.314820343880626 3456 1069125 SGTC_311 1315-0136 58 µM -0.482445098072844 0.346179556750898 no 2204 0.314744895414545 3400 6759207 SGTC_2312 7706453 155.7 µM -0.483506800146573 0.345815736986444 no 2205 0.314367966288082 3239 976098 SGTC_1373 2887-0003 58.5 µM -0.484553722443515 0.345457121252793 no 2206 0.313996473749991 3277 776948 SGTC_953 1188-0045 9.7 µM -0.485328622692471 0.345191774010336 no 2207 0.313721627517342 3359 6144426 SGTC_3001 9076041 71.4286 µM -0.486019904689049 0.344955124175345 no 2208 0.313476526719392 3275 16004211 SGTC_640 3381-0960 37.1 µM -0.486260568577781 0.344872750792746 no 2209 0.313391216299096 3335 1745025 SGTC_1032 k061-1018 98.7 µM -0.490895717604365 0.343287690805105 no 2210 0.31175010302815 3421 4005393 SGTC_3204 9114183 49.47 µM -0.494103217535904 0.342192446787054 no 2211 0.310616642830846 3217 17027248 SGTC_2248 tofa 1.1 µM -0.494849186026434 0.341937915550399 no 2212 0.310353290853685 3191 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_572 0960-0087 17.7 µM -0.495244558917199 0.341803039835906 no 2213 0.310213750322422 3297 6796365 SGTC_937 3122-0005 46.7 µM -0.496996388192884 0.34120567186928 no 2214 0.309595799159696 3384 759535 SGTC_992 3909-8734 162 µM -0.497361221671616 0.341081314856559 no 2215 0.309467173141849 3297 4288319 SGTC_1637 st007924 17.4 µM -0.497559942680661 0.341013586143055 no 2216 0.309397121702039 3292 683336 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.499458215464396 0.340366869372565 no 2217 0.308728308104026 3383 5282362 SGTC_2635 hydroquinidine 100 µM -0.501045019982471 0.339826625691708 no 2218 0.308169719594293 3303 442912 An experimental heart treatment. SGTC_1889 st059080 5.18 µM -0.501970215364059 0.339511785221525 no 2219 0.307844236203579 3412 176925 Isolated from Daphnopsis sellowiana. SGTC_3191 9110352 49.47 µM -0.503494646653324 0.338993271369179 no 2220 0.307308271589565 3361 17122424 SGTC_2473 5854593 8.94 µM -0.506218931190322 0.338067404027695 no 2221 0.30635148327976 3222 2872951 SGTC_2288 7946289 167.31 µM -0.506257980720741 0.338054139870184 no 2222 0.306337778377052 3440 1246052 SGTC_776 4476-4378 112 µM -0.506283695919256 0.338045405164474 no 2223 0.306328753466574 3372 2892008 SGTC_2728 chlorpromazine 9.18 µM -0.5075756811893 0.337606667631141 no 2224 0.305875474460231 3333 2726 A thorazine and dopamine antagonist. SGTC_2523 spermine 47.74 µM -0.508714783111287 0.337220029816007 no 2225 0.305476079388628 3356 1103 A DNA binding polyamine. SGTC_1727 st034309 9.9045 µM -0.509070161852505 0.337099441117823 no 2226 0.305351522844058 3454 870305 SGTC_942 3253-1115 227 µM -0.509157614615155 0.337069768822355 no 2227 0.30532087501643 3437 46497897 SGTC_2600 tangeritin 87.95 µM -0.509677983742287 0.33689323108449 no 2228 0.305138539838377 3321 68077 A bioactive flavone. SGTC_1525 8-methoxypsoralen 92.5 µM -0.510249631208477 0.336699338333252 no 2229 0.304938292679537 3469 4114 Related to psoralen; DNA damaging agent. SGTC_875 0709-0210 25.7 µM -0.511676482936659 0.33621556481202 no 2230 0.304438723798389 3417 6251364 SGTC_1316 1272-0050 65.9 µM -0.512976196069566 0.335775133489552 no 2231 0.30398398593527 3376 7340392 SGTC_1399 3562-5772 25 µM -0.513357944113783 0.335645814065168 no 2232 0.303850479182075 3322 23847490 SGTC_1369 1866-0067 208 µM -0.513559321867412 0.335577603992016 no 2233 0.303780062929483 3428 3531355 SGTC_672 1441-0018 53.7 µM -0.513939642973431 0.335448797539441 no 2234 0.30364709498121 3279 251141 SGTC_2240 6690706 185.951 µM -0.518083271529625 0.334046696932563 no 2235 0.302200085649417 3214 805876 SGTC_2665 lovastatin 100 µM -0.519996303952451 0.333400153680953 no 2236 0.301533075593102 3380 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1035 k081-0041 55.2 µM -0.520525179070283 0.333221498142824 no 2237 0.301348791570136 3433 731709 SGTC_310 1273-0058 1.06 µM -0.521611873185779 0.332854528515757 no 2238 0.300970297399504 3408 2734232 SGTC_2507 purpurin 79.67 µM -0.521880048339628 0.332763992096359 no 2239 0.300876925319897 3276 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_755 1995-0008 37.3 µM -0.522065100621991 0.332701523794999 no 2240 0.300812502225722 3407 689533 SGTC_1603 st002045 67.8 µM -0.522786854154461 0.332457925063359 no 2241 0.300561294368481 3430 5887985 SGTC_484 loperamide 105 µM -0.523565676475715 0.332195144424741 no 2242 0.300290329905242 3341 3955 An opioid-receptor agonist. SGTC_1483 3453-0561 55.9 µM -0.523659496735276 0.332163494312291 no 2243 0.300257695822811 3404 4546991 SGTC_1968 st069590 43.6 µM -0.524732202770821 0.331801703813553 no 2244 0.299884683846329 3384 6384066 SGTC_1334 1486-0610 236 µM -0.525243728753784 0.331629237146326 no 2245 0.299706884853491 3397 3742339 SGTC_2912 7964298 10.93 µM -0.527689429893803 0.330805135573426 no 2246 0.298857455408676 3404 2975850 SGTC_2367 9070478 135.38 µM -0.528692242564997 0.330467465203611 no 2247 0.298509479705505 3392 572802 SGTC_1289 0976-0073 69.1 µM -0.528738576641918 0.330451866774053 no 2248 0.29849340625028 3429 3391136 SGTC_2012 4023501 200 µM -0.534408030198823 0.32854546773843 no 2249 0.296529632202902 3339 3477460 SGTC_651 3253-0966 34.4 µM -0.535490945685713 0.328181833926798 no 2250 0.296155208458513 3352 781462 SGTC_1074 carmofur 3.8 µM -0.536759554719128 0.327756052823481 no 2251 0.295716856297892 3429 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2212 7123476 200 µM -0.537485832760752 0.327512394070932 no 2252 0.295466034184562 3382 1085715 SGTC_2183 6420625 130.508 µM -0.539084650080612 0.326976266372385 no 2253 0.294914223320278 3449 2897619 SGTC_248 streptozotocin 5.23457 mM -0.539785267170665 0.326741442474327 no 2254 0.294672564253248 3415 5300 DNA alkylating agent. SGTC_1550 gossypolone 36.6 µM -0.540206903145084 0.326600156971739 no 2255 0.294527176272626 3407 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1891 st059073 26.2 µM -0.5414024308123 0.326199684281214 no 2256 0.294115116049964 3466 688754 SGTC_949 1165-0505 146 µM -0.543034442547869 0.325653323481609 no 2257 0.293553044194557 3348 6244267 SGTC_221 trifluoperazine 10.304 µM -0.544333118933227 0.325218823222789 no 2258 0.293106130164227 3443 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1896 st058441 89 µM -0.544569508016118 0.325139759680304 no 2259 0.293024815452797 3354 688759 SGTC_3039 9090270 49.47 µM -0.547864871686597 0.324038401642071 no 2260 0.291892345470484 3479 17173750 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.548136004785163 0.32394785341847 no 2261 0.291799259911115 3328 803109 SGTC_2272 7805186 180 µM -0.548279681532032 0.323899875028722 no 2262 0.291749938341183 3448 2956062 YPR165W RHO1 SGTC_879 0831-1030 162 µM -0.548699995355819 0.323759535223939 no 2263 0.29160567468921 3468 1549252 SGTC_1007 4101-0031 70 µM -0.55010728882146 0.323289832391878 no 2264 0.291122893831951 3457 1146276 SGTC_3004 9076122 71.4286 µM -0.551425926327772 0.322849975110807 no 2265 0.290670865988437 3447 44782551 SGTC_3237 9133362 49.47 µM -0.55198205374123 0.322664542180397 no 2266 0.290480324446174 3427 43845137 SGTC_2735 sertaconazole 140 nM -0.552574239855855 0.322467134453429 no 2267 0.290277492689772 3450 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3280 9140961 49.47 µM -0.552618330309327 0.322452438716755 no 2268 0.290262393766662 3324 4901226 SGTC_1044 1222-0021 1.78 µM -0.553035421606766 0.322313432240066 no 2269 0.290119577662055 3405 4306703 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.555384990655006 0.321530842127791 no 2270 0.289315678341836 3427 442882 SGTC_1634 st006576 41 µM -0.556117267462367 0.321287098323686 no 2271 0.289065345753457 3488 3915356 SGTC_223 busulfan 5 mM -0.558018381131442 0.320654657870772 no 2272 0.288415916297374 3452 2478 A DNA alkylator. SGTC_743 1275-0778 158 µM -0.558761163301496 0.320407698951989 no 2273 0.288162365368018 3439 2849257 YMR203W TOM40 SGTC_834 0312-0008 75.7 µM -0.55898564794871 0.320333078328519 no 2274 0.288085757557092 3464 6385573 YIL048W NEO1 SGTC_3058 9093861 49.47 µM -0.560208288356485 0.319926789749051 no 2275 0.287668687125444 3499 17217477 SGTC_404 fumagillin 50 µM -0.561092370188154 0.319633140085471 no 2276 0.287367284596527 3420 12015870 A methionine aminopeptidase binder. SGTC_2015 5119600 184 µM -0.561755152944774 0.319413069506408 no 2277 0.2871414257111 3491 2828786 SGTC_1794 st048918 76.9 µM -0.562541057929931 0.319152199802497 no 2278 0.286873718977413 3420 672303 SGTC_1004 4084-0029 199 µM -0.56274307844918 0.319085156495426 no 2279 0.286804922833894 3476 716894 YLR208W SEC13 SGTC_1420 4'-methoxyflavone 42 µM -0.564645667409463 0.318454046532027 no 2280 0.286157398393155 3461 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2241 6772625 37.8075 µM -0.564659630507301 0.318449416760642 no 2281 0.286152648780156 3450 2285411 SGTC_659 k018-0002 107 µM -0.566492638672479 0.317841889072786 no 2282 0.285529467851412 3478 6797879 YHR007C ERG11 SGTC_1795 st049545 62.3 µM -0.567142708752434 0.317626549074666 no 2283 0.285308614151795 3440 5291882 SGTC_846 0335-0850 148 µM -0.567531569168445 0.317497765980143 no 2284 0.285176542287702 3457 6819598 SGTC_3210 9128157 49.47 µM -0.568107385866653 0.317307107126806 no 2285 0.284981026456203 3365 17590849 SGTC_3321 9137793 26.8275 µM -0.568139296167254 0.317296542713859 no 2286 0.284970193334537 3459 4904192 SGTC_827 3253-0474 693 µM -0.568969294914359 0.317021810727574 no 2287 0.284688488835674 3490 5402065 SGTC_1864 st057645 30.4 µM -0.570712645289965 0.316445085185283 no 2288 0.284097222800818 3512 688666 SGTC_3271 9137798 49.47 µM -0.57297183766359 0.315698375324931 no 2289 0.283331881238631 3443 6498326 SGTC_1212 0520-0165 585 µM -0.573596069465996 0.315492186200659 no 2290 0.283120586085128 3656 5403258 SGTC_3092 9117248 49.47 µM -0.574648616619401 0.315144650927266 no 2291 0.282764482531565 3496 17141857 SGTC_1812 st052057 4.327 µM -0.574960921274545 0.315041564066812 no 2292 0.282658863310428 3440 3645418 SGTC_147 4466-0538 29.23 µM -0.575346105427755 0.314914440668541 no 2293 0.282528622878239 3568 6742687 YHR072W ERG7 SGTC_1149 3909-7961 23.3 µM -0.575847084471244 0.314749133963567 no 2294 0.282359272466494 3447 735261 SGTC_3231 9132313 49.47 µM -0.576115730727221 0.314660504768314 no 2295 0.282268479696712 3442 4905967 SGTC_1657 st012939 43.4 µM -0.577030441925336 0.314358812118333 no 2296 0.281959445615326 3506 24207257 SGTC_717 1532-0246 73.2 µM -0.577543516287345 0.314189642721977 no 2297 0.281786175433447 3445 9561992 SGTC_965 1291-5240 308 µM -0.57818727287185 0.3139774403667 no 2298 0.281568845217696 3497 2834598 SGTC_2832 7992762 51.95 µM -0.578984607627341 0.313714699090106 no 2299 0.281299779618222 3282 2985177 SGTC_741 4582-0002 126 µM -0.579950209774227 0.313396636058658 no 2300 0.280974097406497 3448 2912688 SGTC_944 3370-0224 231 µM -0.581397632141447 0.312920124467792 no 2301 0.280486246478687 3435 4580514 SGTC_701 4424-0219 185 µM -0.581969921118546 0.31273180509615 no 2302 0.280293470743717 3541 2911779 SGTC_714 4296-0578 26.1 µM -0.583771816498741 0.312139186584113 no 2303 0.2796869211281 3482 1589775 SGTC_3144 9087057 49.47 µM -0.584763402462237 0.31181327476613 no 2304 0.279353407821396 3464 17249618 SGTC_2724 maprotiline 69.64 µM -0.585318683903361 0.311630830677607 no 2305 0.279166727053673 3511 4011 A tricyclic antidepressant. SGTC_2005 4024620 188 µM -0.585628512726356 0.311529052954499 no 2306 0.279062591676309 3502 236743 SGTC_476 mead acid 10 µM -0.586517966668689 0.31123695036069 no 2307 0.27876374571816 3488 5312531 An omega 9 fatty acid. SGTC_903 1134-0042 114 µM -0.586673735056538 0.311185807207801 no 2308 0.278711425423933 3429 701009 SGTC_722 3534-0461 190 µM -0.586996314680282 0.311079906814912 no 2309 0.278603090909958 3465 658262 SGTC_3102 9121669 49.47 µM -0.587466926947467 0.310925436504719 no 2310 0.278445078193203 3436 41905072 SGTC_780 0109-0199 192 µM -0.587613698633117 0.310877268058781 no 2311 0.278395807084585 3557 610414 SGTC_737 1950-0117 57.9 µM -0.587695618261246 0.310850384574029 no 2312 0.278368308594707 3497 5393513 SGTC_2488 5268135 45.7 µM -0.58786023826069 0.310796364441834 no 2313 0.278313053541125 3477 1270356 YLR208W SEC13 SGTC_1311 1190-0148 100 µM -0.58819470362908 0.310686622030485 no 2314 0.278200805996503 3527 1961333 SGTC_1563 conessine 56.1 µM -0.588307933019107 0.310649473819274 no 2315 0.278162810888261 3547 441082 An anti-amoebic, histamine inhibitor. SGTC_644 1498-1197 63.3 µM -0.588695505438764 0.310522333972901 no 2316 0.278032776746266 3525 6741615 SGTC_472 calcifediol 10 µM -0.588937758446274 0.310442876420378 no 2317 0.277951513680495 3485 5283731 A vitamin D metabolite. SGTC_3316 9136639 10.545 µM -0.588947357778808 0.310439728078287 no 2318 0.277948293851127 3498 4903665 SGTC_993 3909-8757 62.7 µM -0.591159662143185 0.309714518124291 no 2319 0.277206723738934 3427 4288324 YLR208W SEC13 SGTC_2990 9074105 71.4286 µM -0.59122381402687 0.309693499684215 no 2320 0.277185234311102 3481 6502001 SGTC_99 0109-0120 622.8 µM -0.59231214397813 0.3093370189298 no 2321 0.276820792678093 3555 759414 SGTC_1704 st028805 70.8 µM -0.593077720170702 0.30908636310514 no 2322 0.276564570089619 3484 2876101 SGTC_135 0933-0004 26.348 µM -0.594295201177621 0.308687933033055 no 2323 0.276157343861209 3492 21230617 YGL099W LSG1 SGTC_2475 5812728 15.03 µM -0.594703964771037 0.308554212439306 no 2324 0.276020685573058 3520 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2493 resveratrol 26.09 µM -0.59901805968125 0.307144474658488 no 2325 0.274580420778406 3474 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2603 homopterocarpin 100 µM -0.599064317146723 0.30712937426586 no 2326 0.274564997789837 3509 101795 A weak amylase inhibitor. SGTC_773 4358-1457 44.6 µM -0.599580315295742 0.306960952830653 no 2327 0.274392984624141 3538 1186886 SGTC_2998 9066762 71.4286 µM -0.601503327012418 0.306333642104907 no 2328 0.273752398249484 3580 4945196 SGTC_2929 9013348 24.6 µM -0.601521031079434 0.306327869446981 no 2329 0.273746504175692 3490 2995952 SGTC_1790 st045711 43.5 µM -0.602891098675067 0.305881285699094 no 2330 0.273290568972049 3566 585119 SGTC_1757 st041620 31.8375 µM -0.603448278488117 0.305699751255794 no 2331 0.273105256649071 3513 5289815 SGTC_2505 galangin 7.89 µM -0.604202345626652 0.305454145094025 no 2332 0.272854560823184 3449 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1471 k673-0312 37 µM -0.605004181102453 0.305193076396978 no 2333 0.272588109295768 3513 24099884 SGTC_3025 9087895 49.47 µM -0.605728200829755 0.304957428758393 no 2334 0.272347627118443 3533 17173641 SGTC_1721 st082152 9.2685 µM -0.606717549634127 0.304635554873153 no 2335 0.272019186745902 3509 5296051 SGTC_3156 9099931 49.47 µM -0.606725318012434 0.304633028113608 no 2336 0.272016608607863 3495 18111053 SGTC_2745 rifampicin 24.3 µM -0.606803582391327 0.304607572192329 no 2337 0.271990635219588 3452 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2833 9001315 45.46 µM -0.607076617870994 0.304518773304309 no 2338 0.271900033329824 3423 2989378 SGTC_3077 9117319 49.47 µM -0.60733838215976 0.304433650943889 no 2339 0.27181318568031 3533 17154678 SGTC_2095 5432005 200 µM -0.607565187725828 0.304359905272487 no 2340 0.271737947731415 3499 783734 SGTC_1330 1469-0054 61.8 µM -0.609000636992252 0.303893354527006 no 2341 0.271262008339214 3532 7102664 SGTC_1422 4031-0024 15.5 µM -0.609700064566019 0.303666141708452 no 2342 0.271030255888844 3494 782427 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.610267430523911 0.303481885542689 no 2343 0.27084233409311 3563 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3093 9117344 49.47 µM -0.610411636709408 0.303435061509998 no 2344 0.270794580781754 3540 24824913 SGTC_2815 7968870 71.43 µM -0.611167237190256 0.303189769325053 no 2345 0.270544435380017 3537 2977326 YHR190W ERG9 SGTC_1428 4049-0204 61.7 µM -0.611486828368963 0.303086046453568 no 2346 0.270438667835888 3564 X1428 SGTC_2752 diclazuril 33.15 µM -0.612433074374313 0.302779036750362 no 2347 0.270125632356873 3555 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.613565805495998 0.302411705183603 no 2348 0.269751142696196 3460 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_661 1304-0007 33.6 µM -0.614246910066137 0.302190927131269 no 2349 0.269526089501563 3523 3117130 SGTC_1496 4469-0713 57.4 µM -0.615083813167973 0.301919746545325 no 2350 0.269249685659928 3543 746691 SGTC_158 k038-0087 26.446 µM -0.615555998013994 0.301766793386651 no 2351 0.269093800013962 3493 X158 SGTC_2103 5378138 10 µM -0.615589109548516 0.301756068992051 no 2352 0.269082870373807 3597 244142 SGTC_2308 7584454 197.62 µM -0.616171345500672 0.301567518356207 no 2353 0.268890719087294 3607 893577 SGTC_2686 alizarin 95.37 µM -0.61825222366117 0.300894082749885 no 2354 0.268204544951527 3481 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2252 omeprazole 400 µM -0.62016139322336 0.300276814551674 no 2355 0.267575768066715 3497 4594 A proton pump inhibitor. SGTC_2001 4023502 57.655 µM -0.62020380328577 0.30026310913105 no 2356 0.267561808935044 3537 108941 YCR052W RSC6 SGTC_3064 1327-0027 10 µM -0.62132072234226 0.299902262537214 no 2357 0.267194310936416 3450 16000455 YPR107C YTH1 SGTC_2380 9035439 200 µM -0.621725226411106 0.299771626553373 no 2358 0.267061280512385 3622 6462575 SGTC_1924 st058459 75.1 µM -0.622227634615752 0.299609407980618 no 2359 0.266896098649502 3527 688683 SGTC_199 4063-0024 41.6 µM -0.622451921754609 0.299537002541887 no 2360 0.266822374149953 3565 306215 SGTC_707 0865-0008 204 µM -0.622723162466218 0.299449449924401 no 2361 0.266733229484692 3552 723043 SGTC_330 1488-0319 80.1 µM -0.622732203662433 0.29944653175556 no 2362 0.266730258307981 3521 6846614 SGTC_1224 0823-0416 294 µM -0.624873132596399 0.298755881212518 no 2363 0.266027163629257 3589 3598164 SGTC_2939 9044578 71.43 µM -0.625277442666794 0.298625534582664 no 2364 0.265894491088911 3535 2653634 SGTC_2850 9015429 58.44 µM -0.626269978940084 0.29830565781996 no 2365 0.265568936995791 3525 6457570 SGTC_1296 1068-0102 11.9 µM -0.628130317158801 0.297706524547627 no 2366 0.264959287036849 3527 767053 SGTC_1710 st031758 61.5 µM -0.629207380516637 0.297359900863212 no 2367 0.264606648809287 3595 5394341 SGTC_1974 st069448 26.9 µM -0.629366667496635 0.297308654313757 no 2368 0.264554517387731 3536 6323587 YNR016C ACC1 SGTC_376 3970-0862 59.1 µM -0.629808956744177 0.297166380119016 no 2369 0.264409792425421 3554 3135186 SGTC_2970 9090938 41.86 µM -0.630140860780998 0.297059634732953 no 2370 0.264301213953768 3592 17217104 SGTC_24 0417-1663 219 µM -0.632751730811684 0.296220551435316 no 2371 0.263447891180511 3565 4329390 SGTC_2379 9035213 200 µM -0.633039952519478 0.296127989204458 no 2372 0.26335377660822 3585 646551 SGTC_3243 9134147 49.47 µM -0.633234967546688 0.29606536777268 no 2373 0.263290107049555 3604 24282180 SGTC_1719 st032227 49.2 µM -0.633722310829725 0.295908903157972 no 2374 0.263131030960419 3588 3125804 SGTC_2092 5303694 80.6725 µM -0.634706119915749 0.295593160840545 no 2375 0.262810050751376 3551 1963699 SGTC_3167 9103034 49.47 µM -0.635936256707208 0.295198580509697 no 2376 0.262408984921631 3570 5127859 SGTC_237 nikkomycin 200 µM -0.637110584699501 0.294822127875858 no 2377 0.262026407232463 3609 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1410 3909-8106 77.9 µM -0.637583506083665 0.294670586681799 no 2378 0.261872417642734 3591 1039210 SGTC_1546 5-methoxyflavanone 78.7 µM -0.638527727397047 0.294368131391342 no 2379 0.261565105328541 3608 147795 SGTC_3222 9128301 49.47 µM -0.639908927591936 0.293925960339833 no 2380 0.261115904758759 3576 4911358 SGTC_759 3486-0358 89.3 µM -0.640061240914659 0.293877218265512 no 2381 0.261066392972617 3619 875103 SGTC_2213 7173844 200 µM -0.640426716257492 0.293760277060995 no 2382 0.260947609283216 3558 892728 SGTC_1830 st055982 50.3 µM -0.641741819298342 0.293339661575022 no 2383 0.260520415726578 3558 455313 An antimicrobial agent. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.643244930566295 0.292859256625069 no 2384 0.260032591592122 3590 5106787 A p450 inhibitor. SGTC_2893 9048488 25.97 µM -0.6445504836681 0.292442289255616 no 2385 0.259609266103681 3540 6467338 SGTC_2647 atorvastatin 60.16 µM -0.644827933302516 0.292353712998996 no 2386 0.259519348944197 3574 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2152 5568786 200 µM -0.645243900629185 0.292220938117132 no 2387 0.259384570468349 3572 5399883 SGTC_2 0422-0095 29 µM -0.645858895683285 0.292024685904046 no 2388 0.25918537085992 3489 6790840 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.646378648682334 0.291858874416773 no 2389 0.259017082249732 3572 688664 SGTC_2007 4011539 71.82 µM -0.64798373900682 0.291347095896491 no 2390 0.258497733840591 3595 45595301 SGTC_706 4262-0057 46.9 µM -0.649031926895177 0.291013110341741 no 2391 0.258158870003172 3568 883298 SGTC_331 k048-0133 24.5 µM -0.649806330498587 0.290766476000472 no 2392 0.257908664638558 3582 6813582 SGTC_1660 st012960 28.1 µM -0.649998125596882 0.290705407636536 no 2393 0.257846716186632 3569 24207266 SGTC_1774 st048371 48.465 µM -0.652003604351396 0.290067214368201 no 2394 0.257199423609095 3572 4242727 SGTC_2743 auranofin 4.32 µM -0.653679812577015 0.289534307520306 no 2395 0.256659055946563 3556 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2892 9047358 58.44 µM -0.655349938120228 0.289003792189918 no 2396 0.256121237728999 3579 6466771 SGTC_2286 7945697 125 µM -0.655426797098076 0.288979388948338 no 2397 0.256096501552774 3572 1245733 SGTC_3159 9100096 49.47 µM -0.655943275527109 0.288815428729952 no 2398 0.255930311247174 3577 25236875 SGTC_2914 7968218 45.32 µM -0.65661487802928 0.288602288650326 no 2399 0.255714289951551 3551 2977111 SGTC_1438 4092-1045 4 µM -0.656817404839283 0.28853802919318 no 2400 0.255649165785576 3596 1351342 SGTC_3353 9151644 39.2805 µM -0.657788405520241 0.288230035386309 no 2401 0.255337052861181 3602 4909158 SGTC_98 0074-0023 107.663 µM -0.658795582817041 0.287910730579921 no 2402 0.255013522096265 3576 3563821 SGTC_1109 tnp00067 928.257 nM -0.660917504451474 0.287238566244201 no 2403 0.254332609861921 3583 676295 SGTC_2331 7980721 200 µM -0.660960032215643 0.287225102254899 no 2404 0.254318972699786 3592 2981221 SGTC_533 1222-0222 6.71 µM -0.661335988639266 0.28710609010472 no 2405 0.254198433337244 3663 3982874 SGTC_2587 piperic acid 92.2 µM -0.661559922429808 0.287035213088001 no 2406 0.254126649797599 3565 5370536 SGTC_1945 st075991 56.6 µM -0.662276856468507 0.286808352902981 no 2407 0.253896903115967 3543 1084980 SGTC_2796 7949634 45.45 µM -0.662415282142141 0.28676456051303 no 2408 0.253852556170293 3602 2971588 SGTC_839 0122-0028 230 µM -0.662876901436922 0.286618545401202 no 2409 0.253704698214545 3620 759448 SGTC_1716 st033144 30.6155 µM -0.663774187666389 0.286334825112921 no 2410 0.253417424357497 3632 674617 SGTC_2382 9035899 200 µM -0.663901265678987 0.28629465405526 no 2411 0.253376753070145 3655 6462679 SGTC_2276 7947513 42.08 µM -0.664710713526405 0.286038839601048 no 2412 0.253117770031162 3513 2105100 SGTC_303 1348-1668 34.2 µM -0.665897611587916 0.285663933912714 no 2413 0.252738273623223 3625 5380509 SGTC_1752 st044819 83.042 µM -0.670304805200046 0.284273882656158 no 2414 0.251331752279125 3574 441209 YML126C ERG13 SGTC_2674 ligustilide 100 µM -0.670917894692621 0.284080767593961 no 2415 0.251136417953035 3600 5319022 A signalling regulator. SGTC_840 0245-0196 390 µM -0.671673359909302 0.283842892403146 no 2416 0.250895832272857 3687 3827528 SGTC_2076 5212012 200 µM -0.672021929227481 0.283733169680814 no 2417 0.250784867926017 3533 604802 SGTC_548 1436-0017 110 µM -0.673524893818998 0.283260298922605 no 2418 0.250306708494994 3681 9677137 SGTC_2318 6029776 164 µM -0.67470750764484 0.282888484564252 no 2419 0.249930806866305 3648 818325 SGTC_2238 6671620 73.2395 µM -0.675488407587206 0.282643097791129 no 2420 0.249682756986635 3609 729941 SGTC_2551 apiole 73.87 µM -0.676408569268357 0.282354081345168 no 2421 0.249390639035451 3524 10659 A possible DNA adduct former. SGTC_1902 st060212 70.5 µM -0.676661458144103 0.282274675604649 no 2422 0.249310387827127 3660 688944 SGTC_2611 pyromycin 23.93 µM -0.677157275704963 0.28211902276439 no 2423 0.249153086011264 3626 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1880 MG-132 525 µM -0.677418556885777 0.282037014953125 no 2424 0.249070213853452 3584 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2789 5281112 71.43 µM -0.68078006039573 0.280982971675699 no 2425 0.248005334377437 3651 765948 SGTC_2320 7373003 200 µM -0.680865512230995 0.280956201967972 no 2426 0.247978296073623 3646 5415828 SGTC_1037 k284-1091 78.7 µM -0.681596654785446 0.280727205536862 no 2427 0.247747015399153 3625 3334711 SGTC_2962 9082311 13.18 µM -0.681910408043783 0.280628964596316 no 2428 0.247647801868635 3632 16459453 SGTC_2979 9012552 45.46 µM -0.684270859928979 0.279890404797689 no 2429 0.246902072101364 3700 17100905 SGTC_197 4544-0043 41.561 µM -0.684350875091399 0.279865385449216 no 2430 0.246876814253045 3645 896523 SGTC_542 3381-0244 89.3 µM -0.68937183213662 0.278297593045055 no 2431 0.2452946523349 3665 1112843 SGTC_665 3914-0008 307 µM -0.68962542226792 0.278218523319422 no 2432 0.245214887990362 3644 1069549 SGTC_2700 st077718 96.8 µM -0.69049438020405 0.277947664237973 no 2433 0.244941671404391 3647 904970 SGTC_765 1319-0117 244 µM -0.692099741572714 0.277447602809858 no 2434 0.244437346980305 3643 3487746 YGL099W LSG1 SGTC_843 0310-0051 143 µM -0.693621598990626 0.276973958834652 no 2435 0.243959772410098 3681 2065037 SGTC_3147 9097027 49.47 µM -0.695884673322299 0.27627036054839 no 2436 0.243250528215834 3690 25236841 SGTC_2399 5884133 200 µM -0.696771820767144 0.275994782563374 no 2437 0.24297280190558 3684 722445 SGTC_1213 1315-0166 115 µM -0.6987354110906 0.275385305524869 no 2438 0.242358699803536 3654 768401 SGTC_3268 9137683 49.47 µM -0.70191285837183 0.274400465538789 no 2439 0.241366754748926 3685 1953228 SGTC_1554 st069299 38.7 µM -0.703262736184818 0.273982601852913 no 2440 0.240946014364101 3662 24207999 SGTC_2371 9071574 200 µM -0.703485585255912 0.273913647693637 no 2441 0.240876593421272 3661 45596039 SGTC_3 0833-0587 95.581 µM -0.704146094893154 0.273709322619125 no 2442 0.240670898356516 3633 5382644 SGTC_1575 cyproterone acetate 48 µM -0.706519605070626 0.272975712945243 no 2443 0.239932532560655 3656 9880 An androgen receptor antagonist and liver toxin. SGTC_1058 3448-5425 97.3 µM -0.70698092921061 0.27283323911675 no 2444 0.239789164609315 3615 7279705 SGTC_729 4092-0585 94.1 µM -0.708587141438667 0.272337469785984 no 2445 0.239290359066731 3684 2169061 SGTC_616 4092-0450 108 µM -0.709276862446226 0.27212471971316 no 2446 0.239076341875596 3725 787165 SGTC_537 1334-0398 209 µM -0.710554532686714 0.27173083031762 no 2447 0.238680163379234 3673 5846986 SGTC_2513 baicalein 25.65 µM -0.711536611176666 0.271428261094651 no 2448 0.238375885981442 3681 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2405 ticlatone 3.52 µM -0.712388965175625 0.271165794903997 no 2449 0.23811197341033 3618 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1001 4048-4355 44.4 µM -0.714634880130374 0.270474814738332 no 2450 0.237417342943948 3698 21824233 SGTC_2303 7774051 200 µM -0.71465670717916 0.270468103728599 no 2451 0.237410597602355 3675 2953184 SGTC_813 k007-0158 173 µM -0.715598496931035 0.270178617505436 no 2452 0.237119650997619 3723 6523916 SGTC_3221 9128209 49.47 µM -0.720825940728017 0.268574634475958 no 2453 0.235508306502348 3737 16460723 SGTC_178 4092-0806 87.505 µM -0.721049615637659 0.268506109242061 no 2454 0.235439494407462 3681 2169044 SGTC_1068 loratadine 26.9 µM -0.721393957432914 0.268400633583044 no 2455 0.235333581642134 3734 3957 A H1 histamine antagonist. SGTC_1377 2944-0135 198 µM -0.721432174246359 0.268388928639684 no 2456 0.235321828523485 3777 1894137 SGTC_2685 mycophenolic acid 18.85 µM -0.723321058415338 0.267810726333783 no 2457 0.234741329014829 3693 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1200 1643-0193 18.4 µM -0.725552395245972 0.267128506034377 no 2458 0.234056606791189 3714 5403974 SGTC_1705 st027868 56.3335 µM -0.726087732278809 0.266964959952476 no 2459 0.233892494549358 3726 292948 SGTC_789 1309-1135 70.6 µM -0.726739851009279 0.266765805275659 no 2460 0.233692668025914 3724 3092424 SGTC_1680 diphenhydramine 100 µM -0.727250169023937 0.266610008405823 no 2461 0.23353635904755 3745 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2846 9008642 19.48 µM -0.727366359545724 0.266574542603647 no 2462 0.233500778321652 3738 2992898 SGTC_3334 9142812 21.919 µM -0.727448197253007 0.266549564029634 no 2463 0.233475719174943 3768 45283678 SGTC_464 bw-b 70c 158 µM -0.72862352623829 0.26619095974485 no 2464 0.233115991708673 3743 5353454 SGTC_1863 st057641 20.1 µM -0.729824215646257 0.265824870130646 no 2465 0.232748820264561 3729 3921635 SGTC_3022 9087993 49.47 µM -0.730126721771928 0.265732676421099 no 2466 0.232656364445377 3747 17173644 SGTC_2763 lisinopril 49.32 µM -0.732054029542469 0.265145678615858 no 2467 0.232067795428004 3677 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2011 4012611 177 µM -0.734873030196758 0.264288286625527 no 2468 0.231208412451812 3750 2049887 SGTC_1402 3909-7673 35.9 µM -0.736135543525281 0.263904754572585 no 2469 0.230824106925891 3742 5328014 SGTC_3239 9133757 49.47 µM -0.736266469256922 0.263864997600139 no 2470 0.230784273925114 3727 17036923 SGTC_1248 0469-0687 58.6 µM -0.736903097842429 0.263671722180936 no 2471 0.230590640017017 3735 4017482 SGTC_1884 5633444 25 µM -0.737913955886956 0.263364982089288 no 2472 0.23028336886846 3770 5724239 SGTC_1816 st051957 91.6 µM -0.738020349990171 0.263332707902655 no 2473 0.230251041510686 3729 674121 SGTC_557 1315-0110 16.2 µM -0.738128193322559 0.263299996159832 no 2474 0.230218276401685 3737 6833801 SGTC_3263 9137018 49.47 µM -0.739543296620269 0.26287095015364 no 2475 0.229788579487596 3712 43844957 SGTC_2349 9023730 187.07 µM -0.739952241586513 0.262747028502728 no 2476 0.229664486811686 3715 4126287 SGTC_196 k015-0023 18.111 µM -0.740067669193187 0.262712056149422 no 2477 0.229629467570769 3721 5211998 SGTC_2790 5423970 71.43 µM -0.740480257715134 0.262587069203801 no 2478 0.22950431801422 3777 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_626 0214-0009 33 µM -0.741667165286561 0.262227684731948 no 2479 0.229144509191786 3779 3437874 SGTC_1656 st012921 11 µM -0.742951317484718 0.261839139498792 no 2480 0.228755577416784 3691 6732821 SGTC_802 4112-3352 742 µM -0.743695840005861 0.261614005027925 no 2481 0.228530253367124 3830 704594 SGTC_1193 1488-0126 41.5 µM -0.743791930833305 0.261584955581718 no 2482 0.228501181299246 3764 1384710 SGTC_2120 5538279 151.968 µM -0.745096125622092 0.261190845157973 no 2483 0.22810680556746 3749 2058197 SGTC_2158 5657123 3.6195 µM -0.746039281193673 0.260906026251685 no 2484 0.227821843209463 3732 2858827 SGTC_3158 9100007 49.47 µM -0.746910613034121 0.260643039066877 no 2485 0.227558759591246 3761 19297233 SGTC_1473 k844-0725 134 µM -0.74711172106495 0.260582359609358 no 2486 0.227498062798754 3809 54682906 SGTC_2928 9011484 9.79 µM -0.747652116080012 0.260419344588903 no 2487 0.227335010340823 3763 2994751 SGTC_1750 st081859 2.357 µM -0.748244117559765 0.260240822320652 no 2488 0.227156462353417 3741 5291695 SGTC_975 1335-0046 28.5 µM -0.749017965340707 0.260007558137806 no 2489 0.226923188657095 3759 16486740 SGTC_3175 9106517 49.47 µM -0.749763533760986 0.25978292034535 no 2490 0.226698567527018 3790 41468073 SGTC_399 oxolinic acid 75 µM -0.753189889145676 0.258751857706091 no 2491 0.225667907132893 3735 4628 A DNA gyrase inhibitor. SGTC_423 5-fluorouracil 457 µM -0.753517214095114 0.258653469671062 no 2492 0.225569585498862 3726 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2051 5263410 176 µM -0.753808403718485 0.258565959551688 no 2493 0.225482138548129 3814 227584 SGTC_48 0382-0018 55 µM -0.754821022836532 0.258261760355442 no 2494 0.225178189055613 3826 762596 SGTC_1813 st051246 8.6015 µM -0.755842472865288 0.257955096314781 no 2495 0.224871824142781 3692 5291959 SGTC_2154 5570129 200 µM -0.755948985303673 0.257923129580224 no 2496 0.224839891331096 3779 673366 SGTC_2586 curcumin 80 µM -0.755965108986675 0.257918290686058 no 2497 0.224835057617061 3779 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2835 9006588 71.43 µM -0.75635515160405 0.257801248969777 no 2498 0.224718144811982 3814 2345538 SGTC_833 3852-0053 558 µM -0.756709078929839 0.257695068379774 no 2499 0.224612087180295 3822 3123681 SGTC_435 c-PAF 6.7 µM -0.757011976916528 0.25760421496958 no 2500 0.224521343520423 3787 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1412 3909-8563 178 µM -0.757636049146508 0.2574170786908 no 2501 0.224334446505211 3842 23767530 SGTC_554 4483-2211 187 µM -0.757935716179212 0.257327244691696 no 2502 0.224244733682448 3791 747107 SGTC_131 0141-0277 33.849 µM -0.758575115327184 0.257135620492798 no 2503 0.224053381670582 3727 1547771 SGTC_351 caspofungin 25 nM -0.75878165685104 0.257073737061243 no 2504 0.223991590128504 3795 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_397 arbidol 50 µM -0.759089099346412 0.256981636292476 no 2505 0.22389962972627 3837 131410 A RNA synthesis inhibitor. SGTC_584 0986-0246 15.4 µM -0.760489748834611 0.256562260066096 no 2506 0.223480947268216 3862 53315 YDR232W HEM1 SGTC_917 harmaline 728.087 nM -0.76137315117523 0.25629793910872 no 2507 0.223217109640864 3789 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_389 tpck 16.7 µM -0.761993996227845 0.256112262334225 no 2508 0.223031793717047 3790 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1105 epirubicin 18.1 µM -0.762561166771499 0.255942699389597 no 2509 0.222862575696399 3771 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.762773287188675 0.255879298310494 no 2510 0.222799307363398 3808 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_54 0159-0055 9 µM -0.762993185512214 0.255813581131757 no 2511 0.222733729950336 3784 3319099 SGTC_296 1222-0039 74.9 µM -0.763125275527621 0.255774109927297 no 2512 0.22269434375444 3745 5984176 SGTC_1139 k015-0024 46.9 µM -0.763315609647623 0.255717239782192 no 2513 0.222637597491765 3750 2766652 SGTC_3319 9138450 16.7555 µM -0.763510272498633 0.255659083080516 no 2514 0.222579569187282 3734 2029690 SGTC_186 3455-3465 67.277 µM -0.765419863421402 0.255088947682444 no 2515 0.22201078430201 3728 755278 SGTC_2708 st078559 56 µM -0.766399134475942 0.254796830629001 no 2516 0.221719423827966 3735 17250902 SGTC_1773 st048542 73.5835 µM -0.766726809473317 0.254699124127758 no 2517 0.221621980171805 3736 3237138 SGTC_417 st075190 100 µM -0.76787650292628 0.254356462479449 no 2518 0.221280279149299 3775 222757 SGTC_1951 sophoraflavanone G 9.2 µM -0.770216184535105 0.253659876451942 no 2519 0.220585832480338 3795 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1009 4106-0057 9.87 µM -0.770644886061088 0.253532349194778 no 2520 0.220458724013444 3773 2928005 SGTC_769 0302-0231 76 µM -0.77190309322289 0.25315826075624 no 2521 0.2200859125784 3759 571869 YER009W NTF2 SGTC_1766 st045414 44.774 µM -0.773194596891729 0.252774574790345 no 2522 0.219703611663798 3819 253960 SGTC_3227 9130768 49.47 µM -0.774226968687295 0.252468093270351 no 2523 0.219398291357708 3812 17720899 SGTC_1982 st072467 71.9 µM -0.77489701554671 0.252269280455349 no 2524 0.219200257905126 3784 3163533 SGTC_155 k072-0202 43.6 µM -0.77870968712494 0.251139577494321 no 2525 0.218075374209869 3725 5857737 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.782738981740446 0.249948603262314 no 2526 0.216890202950602 3826 23847180 SGTC_2058 5236698 133 µM -0.783623944495573 0.249687429034645 no 2527 0.216630400792337 3811 766665 SGTC_2757 clomiphene 4.22 µM -0.784787832185774 0.249344157996483 no 2528 0.216288987704652 3852 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1911 st060208 74.3 µM -0.786361899410813 0.248880310099008 no 2529 0.215827749035223 3866 688783 SGTC_1480 1070-0044 41.2 µM -0.786586354703145 0.248814204798343 no 2530 0.215762024832911 3811 3124987 SGTC_1123 mangostin 811.285 nM -0.790231814694533 0.247741874639113 no 2531 0.214696199595138 3851 5281650 An antioxidant. SGTC_1157 4092-0394 27.6 µM -0.790843621942551 0.247562150634643 no 2532 0.214517625467198 3922 3659885 SGTC_1995 st072814 61.1 µM -0.792036652602727 0.247211887346405 no 2533 0.214169652491394 3791 5769371 SGTC_1156 4092-0367 4.88 µM -0.79365066354704 0.246738450045797 no 2534 0.21369941469192 3841 1357585 SGTC_2466 5983409 37.09 µM -0.793841223835176 0.246682585119436 no 2535 0.213643935181425 3831 2879657 SGTC_677 0929-0063 136 µM -0.794686715693315 0.246434801238547 no 2536 0.213397880850831 3791 1539583 SGTC_3113 9123498 49.47 µM -0.796618290966059 0.245869225344941 no 2537 0.212836375609189 3864 8897275 SGTC_2690 usnic acid 100 µM -0.797435558626802 0.245630134776577 no 2538 0.212599057338969 3825 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_689 0833-0039 98 µM -0.800812232003765 0.244643618604352 no 2539 0.211620178288548 3808 5374726 SGTC_1129 3453-1384 223 µM -0.801133442361906 0.244549886260128 no 2540 0.211527198796603 3974 1084452 SGTC_922 1866-0035 480 µM -0.801604459833983 0.244412473713754 no 2541 0.211390898494572 3794 3156169 SGTC_1928 4'-methoxychalcone 40.3 µM -0.803523134217539 0.243853158348973 no 2542 0.210836215433557 3896 641818 SGTC_2360 9040895 200 µM -0.804956245574373 0.243435841196182 no 2543 0.210422464645705 3869 4914414 SGTC_1507 4075-3230 155 µM -0.805062813908343 0.243404824280361 no 2544 0.210391716560946 3743 659771 SGTC_1785 bathophenanthroline 24 µM -0.805158290234955 0.243377037527959 no 2545 0.21036417108543 3780 72812 An iron chelator. SGTC_1451 4152-0210 104 µM -0.805664703080068 0.243229683389457 no 2546 0.210218103437027 3817 659563 SGTC_556 4058-0063 51.5 µM -0.805856611106337 0.243173855304921 no 2547 0.210162765838673 3895 6615692 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.806463454866924 0.242997363606096 no 2548 0.20998783585092 3812 4620898 SGTC_1949 st076024 69.1 µM -0.807148431665187 0.242798231321722 no 2549 0.209790485908278 3800 2921930 SGTC_1523 st012844 44.7 µM -0.808580774359899 0.242382114959767 no 2550 0.209378163552837 3980 4274103 SGTC_1185 1319-0113 81.3 µM -0.810141816949428 0.241929049804716 no 2551 0.208929336432045 3895 4672763 SGTC_1319 1306-0155 43.7 µM -0.81036774611581 0.241863515915828 no 2552 0.208864424816248 3884 3122360 SGTC_3070 9117005 49.47 µM -0.810501348234047 0.241824767300377 no 2553 0.208826045237873 3877 8779016 SGTC_1394 3474-0001 65.7 µM -0.810710799629404 0.241764026903657 no 2554 0.208765884973629 3841 5017666 YIL048W NEO1 SGTC_3303 9125618 40.5795 µM -0.812140998414576 0.241349494108902 no 2555 0.208355365171374 3890 22695467 SGTC_1184 1269-1718 139 µM -0.812794004745042 0.241160353428362 no 2556 0.208168086718174 3910 5403821 SGTC_1215 3852-0577 11.2 µM -0.814101734865632 0.240781816987987 no 2557 0.207793336055553 3925 2884876 SGTC_1708 st033234 31.827 µM -0.814180586730495 0.240759002813825 no 2558 0.207770752556352 3945 674664 SGTC_1425 4048-4433 7.33 µM -0.8155050220861 0.24037598040401 no 2559 0.207391645534352 3897 23734946 SGTC_2756 carbadox 75.1 µM -0.816133337074556 0.240194389899939 no 2560 0.207211939457637 3864 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1450 4112-4260 37.6 µM -0.817807315865769 0.239710955265217 no 2561 0.206733609992705 3815 1633175 SGTC_1736 st036774 51 µM -0.817872272253105 0.239692206973091 no 2562 0.206715062278037 3956 1272247 SGTC_409 arachidonic acid 100 µM -0.818494058733158 0.239512781909505 no 2563 0.206537566580487 3856 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_160 3453-0671 289.699 µM -0.820323479560084 0.238985302837147 no 2564 0.206015862379118 3909 5322268 SGTC_1527 coumarin 137 µM -0.822091449160248 0.238476146161675 no 2565 0.205512425860906 3983 323 A hepatotoxic, DNA x-linker. SGTC_1700 st030840 7.9285 µM -0.822639027383881 0.238318569924217 no 2566 0.205356649016915 3926 5499307 SGTC_1873 rapamycin 2 nM -0.82329435043505 0.238130063014404 no 2567 0.20517031279298 3836 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_919 tnp00227 403.569 nM -0.823298235143026 0.238128945802652 no 2568 0.205169208504865 3868 1269246 A methoxyflavone. YNL221C POP1 SGTC_2842 9000675 19.48 µM -0.823585675928507 0.238046288041493 no 2569 0.205087508830665 3909 2989072 SGTC_1562 morin hydrate 59.1 µM -0.824427001822483 0.237804442997661 no 2570 0.20484848880766 3945 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1098 clofazimine 15.1 µM -0.82573315471248 0.237429247319509 no 2571 0.20447774019216 3944 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1253 0550-0034 176 µM -0.827353823770839 0.236964158231296 no 2572 0.204018272465169 3890 5969915 SGTC_352 k048-0007 5.11 µM -0.829275803254069 0.236413250725913 no 2573 0.203474179775309 3893 6811911 SGTC_777 1315-0167 517 µM -0.829800518379042 0.236262971360287 no 2574 0.203325788849902 3925 4221767 SGTC_2181 6316240 54.2555 µM -0.829923096494259 0.236227872346675 no 2575 0.203291132718623 3896 12779990 SGTC_372 0155-0182 15.9 µM -0.830248885580137 0.236134599870481 no 2576 0.20319904051529 3815 771486 SGTC_1753 st043925 64 µM -0.831871031424062 0.235670486308526 no 2577 0.202740872367199 3928 670181 SGTC_766 1391-0721 126 µM -0.832745346696347 0.235420544016963 no 2578 0.20249418198665 3926 1020919 YIL115C NUP159 SGTC_723 4182-0001 115 µM -0.834023864463986 0.23505531505768 no 2579 0.202133768052691 3868 744821 YLR208W SEC13 SGTC_1066 ketoconazole 628 nM -0.835456067556637 0.234646555412869 no 2580 0.201730486404232 3950 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_540 1187-0821 17.3 µM -0.836190089002355 0.234437213595304 no 2581 0.201523986572669 3841 847520 SGTC_1742 st038235 28.8875 µM -0.836977847435839 0.234212661079482 no 2582 0.201302510053088 3931 564103 YBR002C RER2 SGTC_3311 9131146 2.8755 µM -0.838426786539533 0.233799948464034 no 2583 0.200895525280984 3868 4900406 YPR165W RHO1 SGTC_3135 9127742 49.47 µM -0.838647564210208 0.233737098044912 no 2584 0.200833555593803 3970 3643468 SGTC_3307 9126885 69.2785 µM -0.839114462287463 0.233604213552287 no 2585 0.200702540600314 3867 24824909 SGTC_1205 4161-2785 76 µM -0.839487746357593 0.233498002809972 no 2586 0.200597831293405 3999 3498106 SGTC_2564 betulinic acid 100 µM -0.839629040836786 0.233457807195254 no 2587 0.200558205568118 3909 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_578 3460-0051 92 µM -0.840166402163434 0.233304973094083 no 2588 0.200407546704189 3950 2876744 SGTC_219 mitoxanthrone 164.414 µM -0.84088221393389 0.233101471120075 no 2589 0.200206961694313 3858 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_545 4218-0007 221 µM -0.840975879626405 0.233074849690835 no 2590 0.200180723592652 3875 2840508 SGTC_3173 9105693 49.47 µM -0.841726258322663 0.232861639877381 no 2591 0.199970598368864 3895 17096658 SGTC_1059 3448-6867 171 µM -0.841729610347204 0.232860687688749 no 2592 0.199969660013911 3829 3934407 SGTC_334 1502-1024 68.5 µM -0.843021305196489 0.2324939250797 no 2593 0.199608264229905 3948 3296216 SGTC_916 4466-0038 42 nM -0.84395955508623 0.232227720832899 no 2594 0.199346003352451 3983 5722064 YGL116W CDC20 SGTC_1907 st060210 83.7 µM -0.84667219846833 0.231459033015014 no 2595 0.198588929529022 3950 688793 SGTC_2721 ifenprodil 61.44 µM -0.849967702591146 0.230527090321627 no 2596 0.197671521437453 3878 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_71 0417-1750 47.813 µM -0.851335823198021 0.230140813461583 no 2597 0.197291415311863 3867 6811472 SGTC_415 dibenzyl ketone 100 µM -0.851762832586138 0.230020325291327 no 2598 0.197172869517647 3929 7593 SGTC_2948 9070189 9.45 µM -0.851876785693299 0.229988177396552 no 2599 0.197141241290181 3814 6473636 YDL196W YDL196W SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.852061593396704 0.229936045695038 no 2600 0.197089953559279 3950 4174840 SGTC_2830 7992007 71.43 µM -0.852932762749965 0.229690389946519 no 2601 0.196848295890652 3806 1952075 SGTC_2425 5628681 7.85 µM -0.853566026597441 0.229511912026098 no 2602 0.196672744582652 3976 5714958 SGTC_994 3910-0338 138 µM -0.854543983411904 0.229236439203926 no 2603 0.196401825011262 3996 3479481 SGTC_1207 2099-0101 141 µM -0.857024553345697 0.228538539532795 no 2604 0.195715657580614 3945 5837381 SGTC_829 1635-0120 117 µM -0.858306960966201 0.228178207158986 no 2605 0.195361493356024 3929 285054 SGTC_1070 indatraline 8.81 µM -0.85885695321016 0.22802376762936 no 2606 0.195209720634122 3887 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1011 4112-3381 17.4 µM -0.859044648713136 0.227971075608324 no 2607 0.195157941657409 4007 2877139 SGTC_369 0957-0393 4.5 µM -0.859190593768406 0.227930108982801 no 2608 0.19511768601653 3949 6997992 SGTC_1679 SEC14.276 6.7 µM -0.861363484062497 0.227320671008052 no 2609 0.194518940526206 3931 1005053 YMR079W SEC14 SGTC_2935 9038016 29.96 µM -0.862401485450623 0.227029863581451 no 2610 0.194233311702842 3931 6463195 SGTC_3166 9102297 49.47 µM -0.862835337307846 0.226908377434382 no 2611 0.194114003589344 3948 25237072 SGTC_1006 4099-6547 255 µM -0.863261824797383 0.226788989186539 no 2612 0.193996764180697 3960 3146833 SGTC_2124 5246320 200 µM -0.865029751335389 0.226294464996219 no 2613 0.193511229774036 3943 579342 SGTC_1173 0443-0020 122 µM -0.866029196908927 0.226015169944824 no 2614 0.193237075355254 3919 5331295 SGTC_2299 7976368 114.88 µM -0.866795913216955 0.225801043230792 no 2615 0.193026920857532 3977 2979718 SGTC_2520 obtusaquinone 4.71 µM -0.867115370076114 0.225711859950021 no 2616 0.192939399954026 3940 5967872 SGTC_2435 5706476 10.6 µM -0.868049535993003 0.225451181728871 no 2617 0.192683607634073 3938 5725375 SGTC_2883 9059145 45.46 µM -0.870100225360059 0.224879536690088 no 2618 0.192122817276216 3913 16476510 SGTC_444 curcumin 90.4 µM -0.871053789852994 0.224614003563904 no 2619 0.191862391900285 3889 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_53 0973-0023 39.979 µM -0.871196887008403 0.224574171549807 no 2620 0.191823329686632 3830 674768 SGTC_779 1360-0071 233 µM -0.871428364576843 0.224509746764068 no 2621 0.191760151973884 3998 7566 SGTC_2413 inermin 26.06 µM -0.871869748298185 0.224386930012041 no 2622 0.19163971940047 4050 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2704 st078022 71.1 µM -0.872100970512232 0.224322606747921 no 2623 0.191576648377102 3973 54697681 SGTC_426 0988-0037 14.6 µM -0.873650648769697 0.223891774990768 no 2624 0.191154267286011 3935 5383008 SGTC_1313 1220-0047 237 µM -0.87631269678274 0.22315278801926 no 2625 0.190430032254415 3927 3528706 SGTC_2841 9004761 38.96 µM -0.876952502949786 0.222975384449716 no 2626 0.190256218496048 3954 2991039 SGTC_349 k015-0014 24 µM -0.877213652788124 0.222902996683718 no 2627 0.190185300910263 3934 2196908 SGTC_1367 1812-0510 76.9 µM -0.878812749688297 0.222460037281679 no 2628 0.189751406086534 3980 1142582 YDR527W RBA50 SGTC_1345 1488-0192 31.4 µM -0.879120905002991 0.222374734145584 no 2629 0.189667862035631 3955 658348 SGTC_268 camptothecin 39.6153 µM -0.87931047373341 0.222322267257736 no 2630 0.189616479260377 3916 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2521 angolensin 13.4 µM -0.880481385871117 0.22199835078087 no 2631 0.189299292306725 4018 821428 A flavenoid. SGTC_552 k242-0005 476 µM -0.883912809795309 0.221050648734895 no 2632 0.188371640837243 4030 4088318 SGTC_2111 5486399 200 µM -0.8862426792124 0.220408499534958 no 2633 0.187743384909496 3910 689674 SGTC_608 k048-0125 159 µM -0.886893102383222 0.220229423622138 no 2634 0.187568227801068 3992 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1112 tnp00069 1.16933 µM -0.887453491430874 0.220075203027211 no 2635 0.187417397630582 3964 145826 SGTC_1234 0326-0494 15.5 µM -0.889653864539494 0.219470253873346 no 2636 0.186825886899858 4032 1547813 SGTC_2132 5317594 122.667 µM -0.890041709935701 0.2193637225581 no 2637 0.186721745069856 3929 794577 SGTC_2163 5671233 125 µM -0.890832409071959 0.219146629581208 no 2638 0.186509542800693 3942 701023 SGTC_446 go6976 132 µM -0.891748985732689 0.218895130543826 no 2639 0.186263745401807 3973 3501 A protein kinase C inhibitor. SGTC_781 4335-2806 94.4 µM -0.892689144282135 0.218637333475128 no 2640 0.18601183271162 4059 845254 SGTC_94 0334-0113 514.748 µM -0.893929318396709 0.218297537831218 no 2641 0.185679855002263 3978 6795178 SGTC_1997 st073024 93.8 µM -0.899760670631976 0.216703888273774 no 2642 0.184123814219782 3980 686268 SGTC_3146 9095609 49.47 µM -0.90026452771588 0.216566505755244 no 2643 0.183989746802212 4023 17173999 SGTC_999 SEC7.066 22.7 µM -0.900699556551034 0.216447930606012 no 2644 0.183874042267423 3957 740511 YDR170C SEC7 SGTC_496 calpeptin 138 µM -0.90194887728775 0.216107614098221 no 2645 0.183542012689672 3991 73364 A calpain inhibitor. SGTC_866 0495-0101 262 µM -0.902862612104049 0.215858907941347 no 2646 0.183299407887645 3923 635694 SGTC_2634 4'-methoxyflavone 100 µM -0.902996657624786 0.215822436535061 no 2647 0.183263834424126 3999 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2969 9091408 28.7 µM -0.903259024954751 0.215751061379866 no 2648 0.183194218936773 3932 4286311 SGTC_3345 9148410 3.559 µM -0.903337626350678 0.215729681096296 no 2649 0.183173366371125 3940 4903596 SGTC_2812 7970281 58.44 µM -0.903783584359189 0.215608399779183 no 2650 0.18305508392474 4033 2233435 SGTC_2787 5284540 71.43 µM -0.903800173965689 0.215603888885601 no 2651 0.18305068474557 4027 736958 SGTC_1012 4112-3522 18 µM -0.905729600104769 0.215079630445357 no 2652 0.18253949564137 3997 3112398 SGTC_2097 5376186 200 µM -0.906964545895538 0.214744463148237 no 2653 0.182212773104023 3943 742755 SGTC_2304 7443016 91.4 µM -0.908075831629684 0.214443117083393 no 2654 0.181919079237581 3907 939854 SGTC_3344 9148862 3.898 µM -0.90949369476905 0.214058994004547 no 2655 0.18154479228165 4036 4905352 SGTC_925 2064-1272 59.6 µM -0.910196455276939 0.213868752838566 no 2656 0.18135945661503 3972 6815817 SGTC_2567 aureobasidin a 60 nM -0.911656313146125 0.213473876033909 no 2657 0.180974834099929 4153 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1664 st014217 9.02 µM -0.91188154265948 0.213412991584437 no 2658 0.180915539388474 4014 3982782 SGTC_535 2293-4129 48.2 µM -0.913094011027839 0.213085408895439 no 2659 0.180596549941829 4009 396118 YIL048W NEO1 SGTC_734 2023-0417 80 µM -0.917803454969869 0.211815804681975 no 2660 0.179360886571549 4007 3935732 SGTC_1441 4106-0040 13 µM -0.918188065320867 0.211712314644781 no 2661 0.179260207887005 3972 2904180 SGTC_2703 st077852 53.4 µM -0.919038741643815 0.211483521822795 no 2662 0.179037654308093 4043 6281836 SGTC_2106 5357045 167.29 µM -0.920443243023859 0.211106092540482 no 2663 0.178670589898082 4026 668842 SGTC_2734 clemastine 41.6 µM -0.920857905253976 0.210994736588125 no 2664 0.178562309189211 4014 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2781 5567276 71.43 µM -0.922269483737773 0.210615920821669 no 2665 0.178194013734525 4054 2853274 SGTC_1301 naphtanilide LB 4.81 µM -0.923076117679336 0.210399629224367 no 2666 0.177983769710444 4062 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3072 9116419 49.47 µM -0.924922415720564 0.209905052185849 no 2667 0.177503132868746 4033 17170162 SGTC_1298 1079-1278 263 µM -0.928946164009882 0.208829560951351 no 2668 0.176458493565542 4011 2840950 SGTC_550 4123-0385 25.7 µM -0.929997677176336 0.208549042326428 no 2669 0.176186143579768 4027 5731123 SGTC_3168 9103419 49.47 µM -0.931200627698311 0.20822839645342 no 2670 0.175874896628153 3998 16649256 SGTC_1771 st048882 4.1505 µM -0.932281794760167 0.207940460258031 no 2671 0.17559545680503 4041 4580403 SGTC_2836 9010338 19.48 µM -0.933291256788083 0.207671832864651 no 2672 0.175334804088774 4014 2994051 SGTC_1791 st048313 56.1 µM -0.935550102450378 0.207071475858426 no 2673 0.174752437789786 4028 1204976 SGTC_3062 9077494 49.47 µM -0.937502632227077 0.206553359947221 no 2674 0.174250035204478 4007 16459633 SGTC_635 k038-0028 24.7 µM -0.940055758101241 0.205877031912518 no 2675 0.173594480360985 4020 4035102 SGTC_3109 9122853 49.47 µM -0.940342787663727 0.205801079458676 no 2676 0.17352087930703 4083 1234709 SGTC_2986 9022445 71.43 µM -0.943779634135734 0.204892928917628 no 2677 0.172641134955588 4044 6459286 SGTC_171 k064-0041 9.68 µM -0.944908172523482 0.204595244978908 no 2678 0.172352879418161 4034 53325 SGTC_1440 4100-1550 40 µM -0.946042549096837 0.204296280543199 no 2679 0.172063442279277 4027 742806 SGTC_1954 st077032 68.9 µM -0.949554158336558 0.203372447859878 no 2680 0.171169420408218 4009 698907 SGTC_324 1315-0088 19.6 µM -0.949975638605164 0.203261732796634 no 2681 0.171062315613088 3993 6787421 SGTC_2446 5162541 200 µM -0.950812639814116 0.20304197475125 no 2682 0.170849747500055 4001 1549321 SGTC_350 k064-0020 19.8 µM -0.953420793806312 0.202358103788172 no 2683 0.170188454978127 4057 2790705 SGTC_360 0957-0399 1.01 µM -0.954143778794955 0.202168777651753 no 2684 0.170005434216239 4052 6752301 YPR165W RHO1 SGTC_305 1682-2595 20.8 µM -0.95546783152018 0.201822326409866 no 2685 0.169670582781208 4058 226033 SGTC_2953 9074162 66.49 µM -0.957327343436188 0.201336367734103 no 2686 0.169201029112078 4026 16451992 SGTC_3232 9132874 49.47 µM -0.959502680881966 0.200768763365786 no 2687 0.168652784882573 3995 3784940 SGTC_1350 1495-0454 146 µM -0.959534974990935 0.200760344200756 no 2688 0.168644654498979 4102 1069057 SGTC_1304 1165-0502 251 µM -0.961630902536842 0.200214383275557 no 2689 0.168117521367216 4052 767425 SGTC_356 1634-0012 32.5 µM -0.962101636246588 0.20009188628968 no 2690 0.167999276139609 4060 735457 SGTC_191 3914-0123 66.505 µM -0.962658951378289 0.1999469168552 no 2691 0.16785935144295 4007 3144412 SGTC_2525 harmine 47.85 µM -0.96292186689374 0.199878548908534 no 2692 0.167793367493179 4037 5280953 A monoamine oxidase inhibitor SGTC_60 0986-0278 202 µM -0.962937347621564 0.199874523773959 no 2693 0.167789482813084 3999 3110598 SGTC_2235 salicylic acid 500 µM -0.962978647937991 0.199863785542453 no 2694 0.167779119338392 4070 338 A COX inhibitor and kinase inhibitor. SGTC_2452 5863136 48.41 µM -0.96637861747602 0.198980971624905 no 2695 0.166927379818438 4012 2184096 SGTC_3224 9130643 49.47 µM -0.967342087151252 0.198731231314976 no 2696 0.166686525320627 4105 17644395 SGTC_2180 6301957 200 µM -0.969513781491496 0.198169001467328 no 2697 0.166144453736682 4068 845462 SGTC_771 0250-0039 27.3 µM -0.972598879421812 0.19737195364425 no 2698 0.165376349901882 4010 3005115 SGTC_1826 st055655 41.6 µM -0.973792246723832 0.197064163023512 no 2699 0.165079851770144 4084 676168 SGTC_2656 pseudo-anisatin 100 µM -0.977271903386965 0.196168357545132 no 2700 0.164217279501127 4087 6708809 A neurotoxin. SGTC_724 3910-0327 137 µM -0.978091058197817 0.195957833338693 no 2701 0.164014644970072 4125 2885483 SGTC_873 0591-4978 488 µM -0.97858651703507 0.195830566110001 no 2702 0.163892161956966 4153 3305145 SGTC_2027 5150920 200 µM -0.979096744991299 0.195699557615011 no 2703 0.163766089903566 4002 786715 SGTC_6 0844-0013 19.835 µM -0.981028773410232 0.195203963384837 no 2704 0.163289276284449 4189 1584900 SGTC_306 1672-3436 11.6 µM -0.984722133931408 0.194258686173847 no 2705 0.162380288730811 4121 6797378 SGTC_1333 1482-0047 286 µM -0.985730811107858 0.19400101115334 no 2706 0.162132612867235 4085 3811116 SGTC_2462 5162487 171.77 µM -0.986697896741319 0.193754156698784 no 2707 0.161895380731576 3965 2259986 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.986859946180087 0.193712811340173 no 2708 0.161855651127154 3898 4000243 SGTC_1881 5652484 16 µM -0.988112747886552 0.193393352592806 no 2709 0.161548716584195 4050 2255129 SGTC_3315 9136395 68.55 µM -0.988546825269724 0.193282739854948 no 2710 0.161442456851702 4078 16876844 SGTC_1735 st034310 56.75 µM -0.989855999356941 0.192949366575176 no 2711 0.16112225438704 4147 871153 SGTC_3340 9146634 11.102 µM -0.994944945218081 0.191656836166496 no 2712 0.159881520795336 4109 4907387 SGTC_2764 methyldopa 94.69 µM -0.995410685249104 0.191538809313334 no 2713 0.159768281908523 4086 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1516 st013856 110 µM -0.997115199976235 0.191107234610638 no 2714 0.159354297930699 4127 5281404 A mutagen and neurotoxin. SGTC_2759 disulfiram 3.38 µM -0.997225056763541 0.191079439884077 no 2715 0.159327640580477 3990 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1901 st060216 58.6 µM -0.99762625628613 0.190977953960881 no 2716 0.159230312128371 4047 688792 SGTC_1458 k015-0034 6.33 µM -0.999539225163507 0.190494511336335 no 2717 0.158766773639302 4117 3598957 SGTC_3047 9092122 49.47 µM -0.999788638565835 0.190431535373988 no 2718 0.158706402615676 4066 17173831 SGTC_2159 5658611 73.75 µM -1.0001050084733 0.190351671538089 no 2719 0.158629846289172 4073 793844 SGTC_2017 5132927 60.65 µM -1.00236234864112 0.18978242998809 no 2720 0.158084309900505 4102 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_920 mycophenolic acid 780.421 nM -1.00263502957322 0.189713737997982 no 2721 0.158018493962972 4097 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2545 solidagenone 89.61 µM -1.00333059760324 0.189538584334345 no 2722 0.157850688889993 3888 6708572 An anti ulcer agent SGTC_132 0417-1715 25.805 µM -1.00462976311887 0.189211703046614 no 2723 0.157537580071712 4051 6769098 SGTC_586 0957-0265 8.15 µM -1.00466886626642 0.189201869740293 no 2724 0.157528162245415 3976 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2713 st079149 53.4 µM -1.00554996422168 0.188980382618174 no 2725 0.157316051652145 4121 3103253 SGTC_101 0490-5701 117.494 µM -1.0097777099311 0.187919851133608 no 2726 0.156300900828921 3885 4661669 SGTC_2518 prenyletin 46.28 µM -1.01002736721458 0.187857339637393 no 2727 0.156241089265566 4055 3873459 A coumarin with calcium channel inhibitory activity. SGTC_65 0798-0905 34.986 µM -1.01150739298373 0.187487020880165 no 2728 0.15588682225405 4224 3602145 SGTC_2226 7298446 200 µM -1.01315670901356 0.187074875751459 no 2729 0.155492657360836 4082 3283010 SGTC_4 0960-0234 25.671 µM -1.0136508722561 0.186951499226663 no 2730 0.15537468695928 4107 6821112 SGTC_2385 9074692 200 µM -1.01481876207984 0.186660115188678 no 2731 0.155096114231534 4109 17046906 SGTC_2034 5197015 53.07 µM -1.01514673345688 0.18657833818021 no 2732 0.155017943694112 4119 780676 SGTC_14 0354-0009 295 µM -1.01588140989589 0.186395233080433 no 2733 0.154842931222827 4183 1713507 SGTC_2098 5376439 882.5 nM -1.0189058841697 0.185642609421838 no 2734 0.154123824970134 4151 2844116 SGTC_3274 9138298 49.47 µM -1.01970892794862 0.185443093651139 no 2735 0.153933263102659 4066 17015756 SGTC_2460 5552655 174.22 µM -1.02014725727896 0.185334247152536 no 2736 0.153829313589212 4138 5401989 SGTC_1829 berberine 14.4 µM -1.02060341451149 0.185221015734982 no 2737 0.153721185545762 4109 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2326 6164455 177.58 µM -1.02075022231233 0.185184582933292 no 2738 0.153686396758245 4078 2888790 SGTC_2798 7813637 45.45 µM -1.02154315662347 0.184987880022674 no 2739 0.153498586616256 4126 956368 SGTC_2179 6298986 200 µM -1.02156047547272 0.184983585191579 no 2740 0.153494486264064 4099 738374 SGTC_728 3030-5151 22.5 µM -1.02418226583738 0.184334132778901 no 2741 0.15287459674428 4161 3125388 SGTC_39 0986-0283 58.349 µM -1.02650066141763 0.183761018782616 no 2742 0.152327826008173 4203 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_411 enrofloxacin 100 µM -1.02758597417258 0.183493108241658 no 2743 0.15207231232594 4202 71188 A bacterial gyrase inhibitor. SGTC_1091 telmisartan 47.6 µM -1.02887786199865 0.183174521997281 no 2744 0.151768536233885 4163 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.02936200066439 0.183055219815948 no 2745 0.151654799216778 4130 77254 SGTC_117 lucigenin 22.078 µM -1.02993809068096 0.182913322022196 no 2746 0.151519534220932 4137 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_536 3852-0578 10.6 µM -1.0326032793308 0.182257748258846 no 2747 0.150894796450275 4188 2869208 SGTC_1502 4534-4282 27.7 µM -1.03332279763021 0.182081015696699 no 2748 0.150726430967639 4071 3278949 SGTC_731 3966-0296 387 µM -1.0338514333536 0.181951237199486 no 2749 0.150602811271531 4111 660956 SGTC_1979 st071809 45.3 µM -1.03443375623216 0.181808345638106 no 2750 0.15046671519483 4221 4976333 SGTC_3235 9132602 49.47 µM -1.03502804480349 0.181662590306273 no 2751 0.150327907086836 4141 4912240 SGTC_1084 voriconazole 435 nM -1.03503785937782 0.181660183795737 no 2752 0.150325615411086 4128 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1254 0550-0035 264 µM -1.03692319885815 0.181198272996603 no 2753 0.149885825636096 4187 15121435 SGTC_1646 st011709 75.6 µM -1.03728696416009 0.181109234725886 no 2754 0.149801069607555 4073 5757843 SGTC_3330 9141424 71.43 µM -1.03914212240921 0.180655576949025 no 2755 0.14936932162689 4211 27261020 SGTC_2059 5238311 157 µM -1.03925353016831 0.180628356152569 no 2756 0.149343420347066 4122 703021 SGTC_2118 5526350 200 µM -1.04290061598527 0.17973866669941 no 2757 0.148497162160098 4170 743594 SGTC_2813 7971799 71.43 µM -1.04337336255895 0.179623544294921 no 2758 0.148387702778261 4173 2234054 SGTC_373 0844-0104 25.9 µM -1.0440661041151 0.179454932822821 no 2759 0.148227403425412 4152 5375804 SGTC_3336 9143619 71.43 µM -1.04421390785955 0.179418970663475 no 2760 0.148193216863731 4178 45595730 SGTC_883 0850-0245 24.6 µM -1.04467778103714 0.179306135011345 no 2761 0.148085958654553 4210 6823229 YPR165W RHO1 SGTC_1455 4262-0120 131 µM -1.04488470433625 0.179255815982658 no 2762 0.14803812996146 4208 1529587 SGTC_1948 st076329 66.6 µM -1.04520229803008 0.179178601714595 no 2763 0.147964740791171 3995 24208413 SGTC_3057 9095946 49.47 µM -1.04605141006954 0.17897226597383 no 2764 0.147768648611204 4164 24540043 SGTC_1368 1852-0141 284 µM -1.04646734941511 0.178871246553169 no 2765 0.147672655966741 4159 2838987 SGTC_1284 0929-0043 16 µM -1.04810293934508 0.178474358038629 no 2766 0.147295591103964 4125 1239883 SGTC_585 0kpi-0023 191 µM -1.05042805773868 0.177911105766554 no 2767 0.146760675660382 4091 64601 SGTC_2997 9067075 71.4286 µM -1.05088262586319 0.177801119286039 no 2768 0.146656250469807 4151 27209819 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.05204893757395 0.177519116872711 no 2769 0.146388548852416 4151 229346 A bile salt which induces apoptosis. SGTC_2134 5324836 1.464 µM -1.05270411590508 0.177360825263969 no 2770 0.146238310845173 4105 699272 SGTC_3163 9099914 49.47 µM -1.05879123862978 0.175894434305211 no 2771 0.144847432325862 4167 16268368 SGTC_398 bronopol 33.3 µM -1.05951154902701 0.17572142063967 no 2772 0.144683436191223 4062 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_481 bay k-8644 50 µM -1.0595967756795 0.1757009569119 no 2773 0.144664040553854 4121 2303 A calcium channel antagonist. SGTC_1552 6-methylflavone 10.6 µM -1.05964802312007 0.175688652642187 no 2774 0.144652378651393 4061 689013 SGTC_588 3970-1144 52.9 µM -1.05987166604038 0.17563496341761 no 2775 0.144601493728103 4029 1888707 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.06035322033289 0.175519393551091 no 2776 0.144491967805887 4201 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2210 7115885 190.385 µM -1.06068886569818 0.175438869380054 no 2777 0.14441566084473 4223 2927039 SGTC_1297 1068-0111 14.1 µM -1.06232101657851 0.175047636421024 no 2778 0.144044988281774 4128 767057 SGTC_3143 9086658 49.47 µM -1.06269736387817 0.174957503088033 no 2779 0.143959608360072 4202 25236626 SGTC_3249 9135183 49.47 µM -1.0627704834666 0.17493999472232 no 2780 0.143943024066635 4157 4902779 SGTC_1029 k015-0030 64.7 µM -1.06288685692784 0.174912131580548 no 2781 0.143916631996566 4208 2208316 SGTC_1302 1159-0335 255 µM -1.06336452641912 0.174797793320541 no 2782 0.143808336626468 4165 649284 SGTC_3041 9091929 49.47 µM -1.06406308339487 0.174630667353757 no 2783 0.143650061522362 4164 25236887 SGTC_2984 9022109 38.96 µM -1.06436452374648 0.174558580733046 no 2784 0.143581799189757 4172 6459207 SGTC_2186 6124449 200 µM -1.0664197593148 0.174067594269069 no 2785 0.143116966731845 4160 3834182 YLR033W RSC58 SGTC_200 k038-0079 37.545 µM -1.06713808003159 0.173896197945037 no 2786 0.142954744209389 4127 3436683 SGTC_700 3453-2283 142 µM -1.06733498650115 0.173849233438674 no 2787 0.142910297390193 4211 565664 SGTC_2588 indole-3-carbinol 100 µM -1.06735835377648 0.173843660604473 no 2788 0.142905023419332 4212 3712 Induces cell cycle arrest. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.06808962046897 0.173669319078501 no 2789 0.142740043718809 4197 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1782 st039423 80.636 µM -1.07069478652854 0.173049125036029 no 2790 0.142153343866863 4194 2068169 SGTC_1761 st044296 37 µM -1.0710710185769 0.172959674782022 no 2791 0.142068749094263 4142 1826700 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.07126515765752 0.172913529180968 no 2792 0.142025110770784 4170 75037 A free radical scavenger. SGTC_474 dl-dihydrosphingosine 5 µM -1.07170614665945 0.172808738106136 no 2793 0.141926019569337 4191 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3005 9076496 71.4286 µM -1.07193806109611 0.172753645122481 no 2794 0.14187392666991 4135 21368410 SGTC_643 k048-0106 28.4 µM -1.0725251970702 0.172614216702035 no 2795 0.141742101368593 4172 6763920 SGTC_249 wiskostatin 11.211 µM -1.0737579751532 0.172321699839499 no 2796 0.141465584852994 4124 2775510 A n-wasp and actin depolymerizer. SGTC_2889 9059656 51.95 µM -1.07403826149793 0.172255236901343 no 2797 0.141402766666628 4238 3949838 SGTC_313 3474-0040 5.03 µM -1.07444447365668 0.172158942821059 no 2798 0.141311759360394 4164 1043375 YIL048W NEO1 SGTC_1332 1480-0653 17.5 µM -1.07501819018563 0.172022999752288 no 2799 0.141183292217626 4162 5749438 SGTC_72 0744-0168 198.391 µM -1.07537918874925 0.171937495687626 no 2800 0.141102497681893 4054 677577 SGTC_2905 7799065 20.05 µM -1.07651279737708 0.171669172031613 no 2801 0.140848990314682 4079 1296806 SGTC_1181 1222-0449 220 µM -1.07855696216769 0.171185997449289 no 2802 0.140392637897381 4239 658318 SGTC_855 0428-0020 25 µM -1.07857333309712 0.171182131403377 no 2803 0.140388987203536 4198 6812414 SGTC_162 k030-0015 37.8 µM -1.08020181665009 0.170797838970641 no 2804 0.14002615980255 4245 1809920 YMR134W ERG29 SGTC_2108 5365811 200 µM -1.08056242088758 0.170712817665187 no 2805 0.139945903141014 4177 780283 SGTC_2253 7938677 135.83 µM -1.08159426438864 0.170469684907419 no 2806 0.139716427112966 4242 2301972 SGTC_2322 7413319 38.22 µM -1.08161414175162 0.170465003392618 no 2807 0.139712009015409 4196 1840400 SGTC_511 blebbistatin 171 µM -1.08278772474436 0.170188747166465 no 2808 0.139451327664984 4234 3476986 A myosin inhibitor. SGTC_222 nsc-310342 10.666 µM -1.08693870508543 0.169213928120618 no 2809 0.138531949707334 4185 432556 SGTC_1085 doxorubicin 7.67 µM -1.08865020383198 0.168813044417306 no 2810 0.138154084390599 4199 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2278 7948257 134.34 µM -1.08917394731778 0.168690490223936 no 2811 0.138038592681084 4175 1247028 SGTC_1610 st001799 48.1 µM -1.09247197467616 0.167920077232363 no 2812 0.137312851112533 4108 621897 SGTC_2148 5546263 113.568 µM -1.0930749925786 0.167779458683525 no 2813 0.137180437372909 4163 792097 SGTC_929 2805-0021 398 µM -1.09473193568952 0.167393464437458 no 2814 0.136817046594735 4256 3098024 SGTC_218 alverine citrate 93.75 µM -1.09476775374402 0.167385126743169 no 2815 0.136809198467476 4225 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2182 6325192 200 µM -1.09508842156857 0.167310493900327 no 2816 0.136738950351996 4164 736248 SGTC_1169 aniline yellow 25.8 µM -1.09564663805308 0.167180624699601 no 2817 0.136616721721804 4110 6051 A DNA damaging agent. SGTC_1820 st053765 18.6 µM -1.09596616328042 0.16710631633135 no 2818 0.136546791223791 4247 3690829 SGTC_2594 a-mangostin 100 µM -1.09678680391955 0.166915566817966 no 2819 0.136367300042391 4228 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1137 ixabepilone 100 µM -1.10577194651872 0.164836254591943 no 2820 0.134412620149378 4153 154225 A novel microtubule stabilizer. SGTC_539 4859-0462 2.54 µM -1.10593516969929 0.164798637836473 no 2821 0.134377290452156 4250 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1270 0831-1170 17.3 µM -1.10725491456062 0.164494690939339 no 2822 0.134091865565778 4229 6764716 SGTC_2229 7354935 190 µM -1.10770359655562 0.164391439007744 no 2823 0.133994922805598 4127 318112 SGTC_2263 7948595 193.29 µM -1.10911148258909 0.164067725233445 no 2824 0.133691045980077 4200 2971371 SGTC_298 1391-0729 10 µM -1.10920591704737 0.164046026824817 no 2825 0.133670680303016 4131 3237558 SGTC_1061 3448-9325 110 µM -1.11247721119049 0.163295523849944 no 2826 0.132966511553218 4146 723482 SGTC_2596 sinensetin 100 µM -1.11258491545659 0.163270852240306 no 2827 0.132943370968786 4227 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1824 st053723 68.6 µM -1.11390305579436 0.162969104570787 no 2828 0.132660389168516 4247 675225 SGTC_1163 k060-0048 49.9 µM -1.11522225937319 0.162667476731451 no 2829 0.132377594803074 4193 6809982 SGTC_236 1509-0011 5.31 µM -1.11863764866104 0.16188825713288 no 2830 0.131647377558603 4266 3107280 SGTC_2208 7283366 200 µM -1.11893989875582 0.161819416225895 no 2831 0.131582890013193 4195 898663 SGTC_2933 9026794 32.47 µM -1.12061034738636 0.161439296575523 no 2832 0.131226879292905 4166 17586027 SGTC_145 3737-0113 38.366 µM -1.12230979060659 0.161053177048627 no 2833 0.130865372398343 4166 6849351 SGTC_2373 9071805 200 µM -1.1227642211029 0.160950031034405 no 2834 0.130768822323622 4240 10149009 SGTC_2041 5107442 45.335 µM -1.12282749525365 0.160935672574586 no 2835 0.130755382757096 4251 793005 SGTC_2207 7258803 200 µM -1.12390209321861 0.160691947571986 no 2836 0.130527281615641 4208 3666799 SGTC_510 ag-490 170 µM -1.12576392944642 0.160270243311733 no 2837 0.130132727876304 4340 5328779 SGTC_2018 5133068 143 µM -1.12700163743739 0.159990304164039 no 2838 0.129870894338391 4172 785362 SGTC_1892 st058411 7.36 µM -1.13002304439099 0.159308279978347 no 2839 0.129233257183002 4236 3934738 SGTC_1273 0849-0096 14.1 µM -1.13674907202118 0.157796856031297 no 2840 0.127821599400544 4252 5286025 SGTC_1778 st046819 58.9 µM -1.14114633405031 0.156813843269289 no 2841 0.1269045162625 4270 671715 SGTC_1293 1000-1278 195 µM -1.14184931532218 0.156657065446337 no 2842 0.12675832978026 4269 678847 SGTC_2837 9008476 45.46 µM -1.14386672720499 0.156207718389001 no 2843 0.126339455841254 4244 2992805 SGTC_1108 betulinic acid 729.144 nM -1.1438960842718 0.156201185834347 no 2844 0.126333367580649 4223 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1827 berberine 7.24 µM -1.1442410537389 0.156124436475855 no 2845 0.126261840871463 4157 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3051 9093778 49.47 µM -1.14537470401537 0.15587239518356 no 2846 0.126026986181527 4297 17217378 SGTC_923 1900-2434 73.3 µM -1.14624291898953 0.155679548863821 no 2847 0.125847326947837 4216 5910570 SGTC_128 0906-2981 13.371 µM -1.14871051173979 0.155132311166808 no 2848 0.125337684957058 4228 6740226 SGTC_1489 4065-0444 182 µM -1.14927402163398 0.155007519998134 no 2849 0.125221503326368 4230 2877968 SGTC_2236 dapsone 200 µM -1.15496343908086 0.153751293487124 no 2850 0.124052699348421 4229 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1866 st057638 64 µM -1.15562170926722 0.153606383281229 no 2851 0.123917962113803 4233 688802 SGTC_3061 glucosamine 200 µM -1.15641430110764 0.153432023828603 no 2852 0.123755867362726 4179 91431 and experimental redox chemotherapeutic SGTC_154 3389-1638 511.116 µM -1.15943357503795 0.152769025838133 no 2853 0.123139748851063 4248 5238686 SGTC_2575 plumbagin 510 nM -1.16051829210421 0.152531299020379 no 2854 0.122918925323648 4164 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2434 5670830 169.91 µM -1.16095862252458 0.152434866197898 no 2855 0.122829363425386 4282 1549830 SGTC_192 3455-0609 60.9 µM -1.16381763192656 0.151809724543131 no 2856 0.122248962573884 4317 3769639 SGTC_3261 9137475 49.47 µM -1.16446930042024 0.151667471573945 no 2857 0.122116938741387 4199 17027690 SGTC_2370 9071495 200 µM -1.16534189783041 0.151477130729412 no 2858 0.121940312963808 4258 21791103 SGTC_282 k297-0036 65.7 µM -1.16550975931902 0.151440533100847 no 2859 0.121906356067896 4252 5061378 SGTC_1238 0333-0287 48.8 µM -1.16575553289398 0.151386959469563 no 2860 0.121856650228457 4234 7226 SGTC_2055 5235184 200 µM -1.166359056918 0.151255457009612 no 2861 0.121734652489388 4293 2836034 SGTC_1089 terbinafine 2.25 µM -1.16670055802262 0.151181080659734 no 2862 0.121665658700371 4263 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3267 9137951 49.47 µM -1.1667171836211 0.151177460351707 no 2863 0.12166230051669 4286 16643986 SGTC_808 0711-0032 135 µM -1.16716984091099 0.151078914103127 no 2864 0.121570893870232 4236 4252555 SGTC_1015 4130-4525 82 µM -1.16781747816768 0.150937993871296 no 2865 0.121440198198875 4265 1363237 SGTC_333 3486-0131 40.1 µM -1.17038176764833 0.150380886003617 no 2866 0.120923684755121 4289 6744690 SGTC_1714 st033236 13.627 µM -1.17735555024074 0.148872725760036 no 2867 0.119526811719949 4304 2916566 SGTC_2031 5180455 200 µM -1.17757558647679 0.148825305462852 no 2868 0.119482923711473 4235 29949 SGTC_2456 5770359 74.46 µM -1.17765028642229 0.148809209075213 no 2869 0.119468026787968 4278 3118787 SGTC_1868 st057644 42.7 µM -1.1799951082339 0.148304536948324 no 2870 0.119001080249874 4289 688665 SGTC_2885 9057732 51.95 µM -1.18093026871641 0.148103583636793 no 2871 0.118815212842616 4317 6471414 SGTC_2345 9052315 157.45 µM -1.18165216118276 0.147948583410655 no 2872 0.118671873736083 4294 6469265 SGTC_1321 1326-2144 215 µM -1.18657230177891 0.146895054469345 no 2873 0.117698183354659 4266 3513030 SGTC_2824 7998404 51.95 µM -1.18730225919972 0.14673918148288 no 2874 0.117554208649324 4231 837851 SGTC_193 1273-0060 1.558 µM -1.18738393472919 0.146721747633319 no 2875 0.117538106961634 4105 2847393 YHR072W ERG7 SGTC_2848 9016370 25.97 µM -1.18784125904159 0.146624156272632 no 2876 0.117447977921331 4277 7894410 SGTC_710 3448-4187 58 µM -1.18924873191099 0.146324080022699 no 2877 0.117170901604072 4251 3946412 SGTC_1360 1598-0022 39.8 µM -1.19485924036832 0.145132007879011 no 2878 0.116071015078895 4321 761525 SGTC_2254 7938975 95.19 µM -1.19529664640205 0.145039347058033 no 2879 0.115985574792474 4357 2969277 SGTC_3100 9120536 49.47 µM -1.19552726434111 0.144990508606491 no 2880 0.115940545240083 4144 16421196 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.19565801847761 0.144962823443043 no 2881 0.115915020215576 4184 17037758 SGTC_1467 k284-1082 293 µM -1.19707608981155 0.144662797395289 no 2882 0.115638449248359 4253 3334705 SGTC_440 fluspirilene 35.1 µM -1.2017183076209 0.143683555452816 no 2883 0.114736342781222 4353 3396 An atypical antipsychotic. SGTC_365 0121-0052 13.6 µM -1.20427635669519 0.143145869653167 no 2884 0.114241390941313 4299 3101739 SGTC_1909 st060837 51.5 µM -1.20644702752426 0.14269067568045 no 2885 0.113822586247001 4254 678937 SGTC_2947 9072639 7.68 µM -1.20975323344671 0.1419992400765 no 2886 0.113186798181556 4286 16488146 SGTC_198 3454-2873 16.191 µM -1.20981979167026 0.141985343909147 no 2887 0.113174025011642 4288 710957 SGTC_2449 5812982 45.77 µM -1.21078477076364 0.141783976955434 no 2888 0.112988951683461 4226 776185 SGTC_2030 5175110 200 µM -1.21259150679917 0.141407476709001 no 2889 0.112643018841196 4297 2831986 SGTC_1442 4112-3290 3 µM -1.21265714027045 0.14139381231506 no 2890 0.112630466359502 4290 704353 SGTC_1707 st032323 6.317 µM -1.21331088044173 0.141257757388712 no 2891 0.112505492280052 4154 3132057 YMR211W DML1 SGTC_3170 9103054 49.47 µM -1.21425076308142 0.141062306708041 no 2892 0.112325990601589 4274 16432970 SGTC_837 0091-0265 12.5 µM -1.21485160708315 0.140937456005613 no 2893 0.112211346848654 4265 759367 SGTC_1975 st070967 30.8 µM -1.21560001388898 0.14078204776149 no 2894 0.112068664434432 4288 261391 SGTC_1426 4048-4480 71.7 µM -1.21732001655348 0.140425326418645 no 2895 0.111741240698506 4299 14224343 SGTC_327 1273-0057 3.96 µM -1.21841076252188 0.140199428542411 no 2896 0.111533958622213 4185 3108138 SGTC_2926 9010726 65.15 µM -1.21909299970208 0.140058260027776 no 2897 0.111404448276025 4317 2994293 SGTC_3281 9140613 49.47 µM -1.21944936048852 0.139984560267188 no 2898 0.111336842459218 4303 16013766 SGTC_2468 5987765 72.9 µM -1.22065655244404 0.139735094106453 no 2899 0.111108042259626 4339 26772094 SGTC_2563 tomatine 8.54 µM -1.2209981804515 0.139664551597869 no 2900 0.111043354358305 4276 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3137 9097352 49.47 µM -1.22196202891121 0.139465657806231 no 2901 0.110860993265927 4330 44120435 SGTC_1096 rimcazole 32.2 µM -1.22496919598485 0.138846356125725 no 2902 0.110293413472513 4223 18528119 A dopamine reuptake inhibitor. SGTC_1237 0330-0133 46.1 µM -1.22650860850001 0.138530052396858 no 2903 0.110003668906748 4240 X1237 YHR072W ERG7 SGTC_164 4100-3994 89.624 µM -1.22698585999247 0.138432091115109 no 2904 0.10991395276791 4313 4615967 SGTC_844 0330-0132 15.3 µM -1.22785032177388 0.138254770758017 no 2905 0.109751580606539 4349 2828079 SGTC_2971 9092186 9.93 µM -1.22828534440325 0.138165596524391 no 2906 0.109669935309335 4286 25236400 SGTC_3110 9122132 49.47 µM -1.22832573055878 0.13815731985422 no 2907 0.109662357825009 4380 918317 SGTC_2684 capsaicin 100 µM -1.22965764432317 0.137884549122539 no 2908 0.109412667031057 4340 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2673 kobusone 100 µM -1.23108700549864 0.137592230496902 no 2909 0.109145162534812 4408 6710676 An epoxy ketone and protein crosslinker. SGTC_566 0958-0068 16.5 µM -1.23121335011666 0.137566412124531 no 2910 0.10912153980623 4214 6815365 SGTC_1915 st067105 30.6 µM -1.23388885335529 0.137020452658843 no 2911 0.108622161827869 4248 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_817 1391-0715 46 µM -1.23512947563137 0.136767796106765 no 2912 0.108391160506651 4296 1353946 SGTC_226 1,3-diallylurea 8.28947 mM -1.2355610359434 0.13667998222872 no 2913 0.108310887790112 4238 74537 YKL182W FAS1 SGTC_1056 3448-1962 115 µM -1.2376453471825 0.136256409414144 no 2914 0.107923796106088 4296 715507 SGTC_1597 7-benzyloxygramine 47.5 µM -1.23891045843153 0.135999752559781 no 2915 0.107689330065473 4224 260807 SGTC_1300 1094-0077 113 µM -1.24241558450398 0.135290386860433 no 2916 0.107041634263609 4285 5532636 SGTC_1831 st055328 12 µM -1.24276669333249 0.135219469641021 no 2917 0.106976909664721 4304 1103068 SGTC_2541 muurolladie-3-one 83.07 µM -1.24379020898358 0.135012884647924 no 2918 0.106788392411113 4282 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2597 laccaic acid a 100 µM -1.24448703111252 0.13487236294017 no 2919 0.106660184762032 4318 5491415 A textile dye. SGTC_2865 9030313 51.95 µM -1.24665445437774 0.13443592018638 no 2920 0.106262112861832 4302 42562754 SGTC_1818 st052136 56.3 µM -1.24798930289731 0.134167611682465 no 2921 0.106017487312945 3990 674169 SGTC_2342 7990637 118.86 µM -1.2486213973249 0.134040687250223 no 2922 0.105901791187434 4344 2033102 YER133W GLC7 SGTC_2162 5663267 200 µM -1.25239871800316 0.133283921762763 no 2923 0.105212306615114 4334 6456493 SGTC_2300 7976697 71.57 µM -1.25324994129731 0.133113790508577 no 2924 0.105057379997824 4227 2236109 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.25392854668458 0.132978266955956 no 2925 0.10493398898582 4362 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2794 7785382 27.27 µM -1.25403005942618 0.132958002125643 no 2926 0.104915539919848 4322 2205081 SGTC_1034 k072-0165 12.7 µM -1.25530127719019 0.13270441091669 no 2927 0.104684705853437 4356 5835461 SGTC_1933 st074711 15.9 µM -1.25655009189465 0.132455613403461 no 2928 0.10445829823734 4304 17250958 SGTC_1092 toremifene 6.32 µM -1.25723862920974 0.132318575781536 no 2929 0.10433361963114 4324 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1512 0259-0544 12.2 µM -1.25728867811191 0.132308618502201 no 2930 0.104324561108068 4294 18476 SGTC_647 0140-0236 81 µM -1.25919982162241 0.131928780950366 no 2931 0.103979082993188 4347 990837 SGTC_1349 flufenamic acid 69 µM -1.26133783736222 0.131504744964187 no 2932 0.103593577180564 4269 3371 A non-steroidal anti-inflammatory. SGTC_2402 5553605 200 µM -1.26204089957979 0.131365511319761 no 2933 0.103467034855389 4416 6758546 SGTC_2227 7312221 64.1025 µM -1.26249542670875 0.131275551474737 no 2934 0.103385285443513 4444 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_650 1328-0195 38 µM -1.26593158347646 0.130596845083253 no 2935 0.1027687888636 4337 2780821 SGTC_1409 3909-8004 61.9 µM -1.2670518839853 0.130376089797671 no 2936 0.102568369280931 4386 2119279 SGTC_3220 9131269 49.47 µM -1.26847108087153 0.130096807752626 no 2937 0.102314885878534 4355 17722206 SGTC_753 1322-0200 289 µM -1.26943676887111 0.12990700805624 no 2938 0.102142664581755 4406 5403907 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.26968764817971 0.12985773074614 no 2939 0.102097957167762 4245 4330530 SGTC_1709 st033179 39.1045 µM -1.27143767298401 0.129514353702078 no 2940 0.101786493701321 4337 573381 SGTC_2689 tacrolimus 100 µM -1.27243570092071 0.129318809887342 no 2941 0.101609178084021 4353 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_618 k072-0232 33.2 µM -1.27271046564686 0.129265011118427 no 2942 0.101560401247788 4391 5872756 YGL099W LSG1 SGTC_1747 st037496 66.6 µM -1.27370752290236 0.129069918197893 no 2943 0.101383544668596 4308 723305 SGTC_2872 9044037 25.97 µM -1.27521309496714 0.12877571189677 no 2944 0.101116913796412 4383 6465195 SGTC_2655 perillic acid 100 µM -1.2784614914768 0.128142523102819 no 2945 0.100543377181511 4377 5702197 An apoptosis inducer. SGTC_1482 3346-2049 8.48 µM -1.27857278484548 0.128120867789826 no 2946 0.10052376936856 4374 3826804 SGTC_2081 5214970 32.255 µM -1.2799977419431 0.12784382617633 no 2947 0.100272965028519 4301 2063512 SGTC_1955 wogonin 32.4 µM -1.28007347146845 0.127829114423769 no 2948 0.100259648793017 4380 5281703 A flavanone. SGTC_642 0335-0876 158 µM -1.28009452858637 0.127825023928351 no 2949 0.100255946351062 4396 6812350 SGTC_2804 7954240 19.48 µM -1.28054182083301 0.127738155705709 no 2950 0.100177323189336 4374 828705 SGTC_35 0133-0054 64.071 µM -1.28084013115413 0.127680243941268 no 2951 0.100124912473459 4319 99677 SGTC_1499 4480-0877 67.3 µM -1.28169573523292 0.127514244530593 no 2952 0.0999747007974954 4342 2861909 SGTC_3145 9085516 49.47 µM -1.28488194045531 0.126897395452678 no 2953 0.0994167713468038 4339 25236195 SGTC_880 0833-0487 87.2 µM -1.28933396606583 0.126038967440382 no 2954 0.09864100371454 4349 76075 SGTC_1277 0873-0036 22 µM -1.290870114618 0.125743712937681 no 2955 0.0983743599592745 4433 5965735 SGTC_1154 4088-0362 150 µM -1.29089093998381 0.125739713528463 no 2956 0.0983707487346258 4359 6618304 SGTC_1686 st019653 115.5 µM -1.2933028181081 0.12527712431648 no 2957 0.0979531731853265 4352 97252 SGTC_1653 st012112 65 µM -1.29445233511965 0.125057069856359 no 2958 0.0977546116496578 4346 720429 SGTC_2237 6667747 47.222 µM -1.29619680713664 0.124723637887743 no 2959 0.0974538446431465 4377 729940 YDL015C TSC13 SGTC_3255 9139072 49.47 µM -1.30286336493822 0.123455142615238 no 2960 0.096310706571629 4359 17646060 SGTC_2487 5918373 44.05 µM -1.3037262581671 0.123291616465953 no 2961 0.0961634665923035 4424 2876279 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.30769875095606 0.12254075067563 no 2962 0.0954877535845443 4465 688801 SGTC_1663 st014140 55.4 µM -1.30770582913509 0.12253941565442 no 2963 0.095486552727503 4433 4207120 SGTC_2129 girgensonine 121.053 µM -1.3119982910735 0.121731689692984 no 2964 0.0947603555790425 4378 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3223 9129970 49.47 µM -1.31230017156829 0.121675025031681 no 2965 0.0947094371514451 4387 17248386 SGTC_1343 1487-0095 224 µM -1.31692148800225 0.120809891167499 no 2966 0.0939324714681119 4371 4560101 YGL055W OLE1 SGTC_2476 5806916 10.51 µM -1.31738941460543 0.120722534922529 no 2967 0.0938540636467335 4277 2870194 SGTC_733 4069-0007 56.1 µM -1.32239883956694 0.119790121197242 no 2968 0.0930176875413463 4392 5717425 YNL287W SEC21 SGTC_3298 9116858 71.43 µM -1.32252972281825 0.119765827909772 no 2969 0.0929959093016051 4444 2506942 SGTC_3318 9139014 38.6185 µM -1.32354329039721 0.119577816882757 no 2970 0.0928273849359757 4374 16643984 SGTC_3199 9111318 49.47 µM -1.3237826181905 0.119533453336426 no 2971 0.0927876252377207 4308 8548020 SGTC_509 pifithrin 175 µM -1.32446586495189 0.119406865623408 no 2972 0.0926741862586879 4456 4817 A p53 inhibitor. SGTC_577 r071-0003 38.6 µM -1.32482544215104 0.119340283398188 no 2973 0.0926145271218148 4346 4568517 YMR134W ERG29 SGTC_2639 lactacystin 53 µM -1.32869373052863 0.118625656484755 no 2974 0.0919745170910183 4407 3870 A proteasome inhibitor. SGTC_234 nsc-17383 10.7 µM -1.329272377644 0.118519017848667 no 2975 0.0918790619587747 4406 408974 SGTC_573 3702-0553 84.7 µM -1.33148961516098 0.118111031280709 no 2976 0.091513979893386 4332 1222756 SGTC_693 4161-2696 114 µM -1.33209021556705 0.118000687950146 no 2977 0.0914152725721105 4427 805759 SGTC_3103 9120822 49.47 µM -1.33265858883338 0.117896332620201 no 2978 0.0913219344085753 4397 17141819 SGTC_157 1348-1695 65.819 µM -1.33323341354044 0.117790859210827 no 2979 0.0912276086702297 4320 5380510 SGTC_3285 9112818 20.8695 µM -1.33513330761224 0.117442726659622 no 2980 0.0909163599375036 4363 17017947 YPR165W RHO1 SGTC_1941 st076221 61.8 µM -1.34049619961013 0.11646397441833 no 2981 0.090042039522428 4270 2828568 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.34216100873818 0.116161319331781 no 2982 0.0897718979659306 4373 364106 SGTC_2463 5473429 200 µM -1.34586772120672 0.115489461107495 no 2983 0.0891725902049313 4389 5399405 SGTC_1763 st044482 94.5 µM -1.35689851857853 0.113506428396095 no 2984 0.0874067288181096 4383 88505 SGTC_480 am 92016 50 µM -1.35749796002971 0.113399365257779 no 2985 0.0873115206006461 4420 2129 K+ channel blocker. SGTC_1607 st000305 50.6 µM -1.35937700468518 0.113064225601265 no 2986 0.0870135770148701 4413 5457690 SGTC_2710 st078562 53.7235 µM -1.3600422203128 0.112945749706776 no 2987 0.0869082818387317 4361 17250908 SGTC_3219 9131112 49.47 µM -1.361442322664 0.112696678981242 no 2988 0.0866869745035055 4278 17612988 YMR079W SEC14 SGTC_1731 st035964 63 µM -1.36186107875727 0.112622260765032 no 2989 0.08662086566645 4321 6739575 SGTC_2677 mitomycin C 100 µM -1.3643359431084 0.112183162890584 no 2990 0.0862309292167371 4481 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2474 5321570 43.32 µM -1.3656405575964 0.111952187412615 no 2991 0.0860259050352137 4399 2841384 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.36914712119929 0.111333053659201 no 2992 0.0854766456695928 4445 6710655 SGTC_1383 3049-0032 20.7 µM -1.37208266146509 0.110816630108676 no 2993 0.08501885318806 4469 712864 SGTC_679 0422-0091 41.4 µM -1.3753393792639 0.11024571544164 no 2994 0.0845131266765474 4456 627384 YHR062C RPP1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.38062072252375 0.109324366113883 no 2995 0.08369780416823 4449 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3193 9111931 49.47 µM -1.3809625163845 0.109264930089724 no 2996 0.0836452430561608 4414 17087244 SGTC_2153 5569715 200 µM -1.38600565961002 0.108390653060751 no 2997 0.0828725876612004 4438 2054701 SGTC_2100 5377183 190 µM -1.38614006033968 0.108367422471895 no 2998 0.0828520699527939 4455 2844202 SGTC_2882 9058044 58.44 µM -1.38940370839382 0.107804414326724 no 2999 0.0823550116344612 4444 18076804 SGTC_2778 tioconazole 65.09 nM -1.39271427460151 0.107235468057824 no 3000 0.0818531051339685 4321 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1235 benzylparaben 21.5 µM -1.39394579309876 0.107024375581243 no 3001 0.0816669872100804 4463 7180 SGTC_1501 4491-0275 38.4 µM -1.39436847951288 0.106951992762077 no 3002 0.081603180715583 4429 5104718 SGTC_2856 9022925 19.48 µM -1.3948333875505 0.106872420502076 no 3003 0.0815330440845948 4444 4944862 SGTC_1625 st003711 30.1 µM -1.40058503990331 0.10589151615253 no 3004 0.0806690985601858 4459 24207034 YER133W GLC7 SGTC_3112 9123419 49.47 µM -1.40181786652391 0.105682115640282 no 3005 0.0804848208988911 4490 17015854 SGTC_1815 st051655 58.2 µM -1.4042030116488 0.105277839486535 no 3006 0.0801292026571748 4374 5984156 SGTC_1608 st001473 40.5 µM -1.41588496464423 0.103313934092633 no 3007 0.078404593871895 4385 7292267 SGTC_3350 9150499 3.57 µM -1.41759325028212 0.103028990413648 no 3008 0.0781547759511192 4453 4910996 YPR165W RHO1 SGTC_1860 st056228 74.6 µM -1.41882303890746 0.102824214181615 no 3009 0.0779753070492805 4435 688679 SGTC_1355 1499-0035 1.68 µM -1.41899070992866 0.102796317642915 no 3010 0.0779508622628001 4442 1548538 SGTC_2568 diosmetin 100 µM -1.42322457699023 0.102093722963155 no 3011 0.0773355315827045 4459 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_885 0865-0106 16.8 µM -1.42490277043594 0.101816202000209 no 3012 0.0770926543554797 4415 2793380 SGTC_3078 9116413 49.47 µM -1.4321119009277 0.100630281797645 no 3013 0.076055899542301 4403 17177322 SGTC_80 0159-0065 512.242 µM -1.43233593757628 0.100593589313526 no 3014 0.0760238514249783 4397 1548079 SGTC_987 1497-1013 404 µM -1.43296244586401 0.100491032261772 no 3015 0.0759342849010226 4472 1676435 SGTC_512 prima-1 270 µM -1.43350223063863 0.100402732718861 no 3016 0.0758571809514033 4463 322968 A re-activator of the apoptotic function of mutant p53. SGTC_19 0279-0214 38.434 µM -1.43549041408959 0.100077988288631 no 3017 0.0755736990011259 4524 3566274 YBR002C RER2 SGTC_1526 st051518 75 µM -1.43569462617023 0.100044676328554 no 3018 0.0755446275220957 4451 673993 SGTC_1780 st038448 24.544 µM -1.43859024011148 0.0995732022574591 no 3019 0.0751333266113822 4483 728868 YDL195W SEC31 SGTC_1392 3455-1037 33.9 µM -1.44177722414532 0.0990561655898426 no 3020 0.0746826150259194 4454 981132 SGTC_1833 st055984 71 µM -1.4439249589106 0.0987088396527729 no 3021 0.0743800424991312 4481 676288 SGTC_169 k015-0017 16.025 µM -1.44440816444732 0.0986308199157215 no 3022 0.0743120977370023 4451 1840002 SGTC_506 n9-isopropylolomoucine 153 µM -1.44911075022939 0.0978738832743474 no 3023 0.0736533281630909 4456 6610355 SGTC_325 2810-4341 181 µM -1.45313150754911 0.0972300788030287 no 3024 0.0730936222457761 4469 774970 SGTC_2771 fluoxetine 41.05 µM -1.4544163446551 0.0970250070217341 no 3025 0.0729154555771487 4455 3386 A selective serotonin reuptake inhibitor. SGTC_2033 5192550 145 µM -1.46314713860622 0.0956398955275355 no 3026 0.0717135608203067 4483 182073 SGTC_1168 k815-0004 80.5 µM -1.46330813983295 0.0956144905588285 no 3027 0.0716915407155124 4468 642433 SGTC_1606 st000094 49.2 µM -1.46457315875298 0.095415051396606 no 3028 0.071518704781142 4494 1242210 SGTC_1587 estradiol valerate 56.1 µM -1.46794373801007 0.0948851510110773 no 3029 0.0710597530758241 4526 13791 A steroid. SGTC_2028 5153890 36.43 µM -1.46796470392684 0.0948818616863521 no 3030 0.0710569053669198 4456 2830968 YPR165W RHO1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.46992573944852 0.0945745678241111 no 3031 0.0707909337605125 4498 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_995 3931-2021 34.6 µM -1.47609303040769 0.0936129370527611 no 3032 0.0699594598260875 4498 730143 SGTC_1229 0139-0193 12.2 µM -1.48017581561452 0.0929803155090416 no 3033 0.0694131663754552 4542 3090752 SGTC_2696 st077691 74.316 µM -1.4888473021111 0.0916471757686437 no 3034 0.0682637915286139 4504 757133 SGTC_3134 9127454 49.47 µM -1.48911774876517 0.0916058266921506 no 3035 0.0682281824060615 4537 24262820 SGTC_1642 st009582 77.7 µM -1.48962112426199 0.0915289015181753 no 3036 0.0681619422261196 4475 6739311 SGTC_502 l-744,832 89.3 µM -1.49221072277298 0.0911339190306186 no 3037 0.0678219561070219 4510 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_183 3914-0051 30.55 µM -1.49265197013257 0.0910667433340053 no 3038 0.0677641559530755 4480 1596232 SGTC_2621 lithochol-11-enic acid 100 µM -1.49399504586227 0.0908624989079974 no 3039 0.0675884570779608 4441 6708711 SGTC_3256 9138902 49.47 µM -1.49479114446719 0.090741595019439 no 3040 0.0674844790932124 4601 17228773 SGTC_3065 9113888 49.47 µM -1.49727773360338 0.0903647243670015 no 3041 0.0671605030766975 4509 16648368 SGTC_1561 5-methoxyflavone 52.9 µM -1.49813561939739 0.0902349721431144 no 3042 0.0670490091808194 4455 94525 SGTC_2875 9039966 71.43 µM -1.50233462630864 0.0896018828536452 no 3043 0.0665053551888512 4478 6463691 SGTC_217 ketoconazole 989 nM -1.50237856540347 0.0895952756103003 no 3044 0.0664996843998425 4297 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1882 5615643 20 µM -1.50304793411264 0.0894946655790484 no 3045 0.0664133418106619 4470 2253075 SGTC_79 0052-0007 94.094 µM -1.50566907478454 0.0891015014757396 no 3046 0.0660760732778271 4478 2801472 SGTC_138 0850-0259 40.9225 µM -1.50908516403735 0.0885910284634386 no 3047 0.0656385101980491 4439 6813004 SGTC_2742 clothiapine 36.27 µM -1.51209076009596 0.088143700593101 no 3048 0.0652553875619449 4545 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2206 7254556 146.969 µM -1.51526068692166 0.0876737418169707 no 3049 0.0648531999433507 4532 4398905 SGTC_2827 7993847 71.43 µM -1.5160668221666 0.0875545266100779 no 3050 0.0647512283049592 4536 2985692 SGTC_1571 st070080 73.4 µM -1.5181086656948 0.087253110133583 no 3051 0.0644935034787771 4503 4315245 SGTC_1230 0170-0365 3.77 µM -1.52612407059428 0.0860773659044149 no 3052 0.0634894842479508 4528 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1263 0774-1208 64.8 µM -1.52715215992627 0.085927421812269 no 3053 0.063361589595288 4502 906585 SGTC_3046 9092212 49.47 µM -1.52736348764185 0.0858966244610281 no 3054 0.0633353252238624 4577 25236637 SGTC_1886 st057356 49.9 µM -1.52785572445165 0.0858249215099184 no 3055 0.0632741815840303 4496 24207747 SGTC_2306 7482397 179.52 µM -1.53086750266284 0.085387178389472 no 3056 0.0629010711478079 4502 891448 SGTC_384 k007-0144 5.16 µM -1.531204260289 0.0853383369158606 no 3057 0.0628594591098515 4456 6824886 SGTC_639 0833-0042 114 µM -1.53184186684344 0.0852459192982202 no 3058 0.062780730907036 4531 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3186 9110464 49.47 µM -1.53250078136384 0.0851504920146935 no 3059 0.062699452464415 4503 17018021 SGTC_322 k048-0136 19.3 µM -1.53282186255017 0.0851040204554016 no 3060 0.0626598761777713 4562 6823282 SGTC_455 paf C-16 10 µM -1.53702493680879 0.0844974419382567 no 3061 0.06214360144775 4483 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1436 4092-1007 8.32 µM -1.53712840485246 0.084482550667514 no 3062 0.062130934172327 4516 2881121 SGTC_2062 5245942 200 µM -1.53799820473881 0.0843574456428152 no 3063 0.062024526868327 4544 1376160 SGTC_2968 9090663 33.37 µM -1.54062258520322 0.0839808183717349 no 3064 0.0617043339296788 4454 25236811 SGTC_2416 tofa 880 nM -1.54109382995505 0.0839133235243186 no 3065 0.0616469756574914 4460 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_301 4119-0100 24.5 µM -1.54253518743966 0.0837071354448916 no 3066 0.0614717970193685 4535 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_419 nsc-638432 893 µM -1.54407338604181 0.0834875141872934 no 3067 0.061285277701618 4486 368090 SGTC_2598 perillyl alcohol 100 µM -1.54981355427051 0.0826717656622631 no 3068 0.0605931364010303 4525 10819 An apoptosis inducer. SGTC_666 0272-0154 136 µM -1.55007423576651 0.0826348625163699 no 3069 0.0605618495544495 4521 6870312 SGTC_2650 prasterone 100 µM -1.55192654802461 0.0823729985303184 no 3070 0.0603398999016875 4542 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1789 tunicamycin 25 nM -1.55551255148969 0.0818678167186528 no 3071 0.0599120238198474 4434 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1840 st055363 71 µM -1.55758950925243 0.0815762929949443 no 3072 0.0596652935647056 4545 676033 SGTC_811 0416-0114 265 µM -1.56015541650353 0.0812172215459346 no 3073 0.0593615792271463 4544 6612453 SGTC_395 anisomycin 6.25 µM -1.56377714154548 0.0807124308342397 no 3074 0.0589349571110048 4540 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2666 tannic acid 100 µM -1.56612152079432 0.0803869401670111 no 3075 0.058660085387938 4491 16134267 A thiamine antagonist. SGTC_505 gw-5074 63.9 µM -1.5664334175816 0.0803437116668288 no 3076 0.0586235923595054 4539 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1970 st070122 35.8 µM -1.56936468601647 0.0799382995118874 no 3077 0.0582814938305843 4550 102928 SGTC_2619 obliquin 87.91 µM -1.57064258365862 0.0797620434968457 no 3078 0.058132846379934 4512 6708593 A bioactive alkalod. YER133W GLC7 SGTC_49 0717-0965 32.132 µM -1.57391069965629 0.0793126208667754 no 3079 0.0577540479739266 4585 5889349 YGL099W LSG1 SGTC_2437 5741531 144.16 µM -1.57514058544534 0.0791439875829111 no 3080 0.0576119988913084 4546 2262990 SGTC_962 1254-0300 21.5 µM -1.58182218007458 0.0782325951671114 no 3081 0.0568450850534228 4518 7340576 SGTC_2515 chrysin 20.77 µM -1.58410912977338 0.0779224827589644 no 3082 0.0565844435633058 4531 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1138 3761-0006 1.03 µM -1.58772209514168 0.0774344636232867 no 3083 0.0561745972385579 4572 12061087 SGTC_1776 st049249 45.9 µM -1.5887902836072 0.0772906242279426 no 3084 0.0560538738181534 4555 1822314 SGTC_1320 1313-0481 95.3 µM -1.59130459810316 0.0769528546468323 no 3085 0.0557705212584117 4490 6813365 YLR208W SEC13 SGTC_2924 9010168 62.78 µM -1.59183337750374 0.0768819621518498 no 3086 0.055711074155173 4541 2993929 SGTC_2822 7994718 71.43 µM -1.59377695075493 0.0766218173892667 no 3087 0.0554930009078594 4542 1018011 SGTC_1396 3511-0007 98.6 µM -1.59810420747739 0.0760450249221659 no 3088 0.0550098937071842 4572 X1396 SGTC_2389 9091542 195.52 µM -1.59912886838598 0.0759089302103255 no 3089 0.0548959857039846 4511 3626624 YOL127W RPL25 SGTC_1930 st074634 34.3 µM -1.6107438684734 0.0743791756756625 no 3090 0.053617779968909 4458 684253 YOR116C RPO31 SGTC_1904 st060225 78 µM -1.61297699645404 0.0740877780581551 no 3091 0.0533747527775924 4537 66595 SGTC_954 1189-0853 2.85 µM -1.61453985977323 0.07388436160989 no 3092 0.0532051891268781 4493 2828194 SGTC_2205 7238770 200 µM -1.61611801482551 0.0736793882125118 no 3093 0.0530344000030899 4591 279867 SGTC_2341 7987486 176.74 µM -1.61653709562873 0.073625030415983 no 3094 0.0529891198939232 4551 1258686 SGTC_538 2922-0838 53.3 µM -1.61681464488047 0.0735890471607297 no 3095 0.0529591486184603 4572 777039 SGTC_2447 5741742 33.78 µM -1.61915213519715 0.0732865332899297 no 3096 0.0527072668440005 4599 1776504 SGTC_3142 9086498 49.47 µM -1.63282053205341 0.0715366065008954 no 3097 0.0512533737462997 4419 25236367 SGTC_1814 st052110 31.539 µM -1.63497691617923 0.0712634834249926 no 3098 0.0510269434053658 4507 674163 SGTC_261 5-fluorouridine 15.376 µM -1.63960359585232 0.0706801801029524 no 3099 0.050543807480879 4578 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1274 0865-0114 173 µM -1.64741537596209 0.0697036554807377 no 3100 0.0497363485284711 4556 870624 SGTC_302 1094-0063 18.9 µM -1.65075234212102 0.0692896919645941 no 3101 0.0493945775650747 4562 5440289 SGTC_2584 androsterone 48.74 µM -1.65116113358805 0.0692391102975277 no 3102 0.0493528384972232 4462 2754130 A steroid. SGTC_2766 oltipraz 83.91 µM -1.65472993626149 0.0687987332640898 no 3103 0.048989645869548 4539 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_486 niguldipine 82 µM -1.65862301112186 0.0683208084371746 no 3104 0.0485958909531461 4644 1236 A calcium channel blocker. SGTC_3010 9080089 71.4286 µM -1.66189878913235 0.0679206529775646 no 3105 0.0482665347648932 4570 17027233 SGTC_2231 micatex 6.853 µM -1.66564679411295 0.067465034925174 no 3106 0.0478918925327856 4595 20737 An antifungal of unknown mechanism. SGTC_2479 5617353 43.85 µM -1.66571423141335 0.0674568587423023 no 3107 0.0478851730313202 4583 2731746 SGTC_410 α-linolenic acid 100 µM -1.66890442200627 0.067070950341538 no 3108 0.0475681615578599 4606 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_692 k241-0027 77.8 µM -1.67211587679666 0.0666841963752348 no 3109 0.0472507372225888 4600 3600480 SGTC_820 1582-0060 59.9 µM -1.68151431071035 0.0655622607736294 no 3110 0.046331529567246 4608 3848840 SGTC_979 1426-2828 121 µM -1.6856714294665 0.0650706989522952 no 3111 0.0459295513833466 4641 747872 SGTC_978 1416-0512 87.4 µM -1.6916447320444 0.0643693948195984 no 3112 0.0453568660486981 4609 6814003 SGTC_1317 1273-0028 910 nM -1.69497088896408 0.0639814363359543 no 3113 0.0450404716617581 4600 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1594 piperine 70.1 µM -1.69807602401039 0.0636209008372181 no 3114 0.0447467070551813 4574 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1282 0886-0010 32.4 µM -1.70054304662264 0.0633355846985043 no 3115 0.0445144132947498 4603 2836211 YNL267W PIK1 SGTC_1143 3454-2408 5.08 µM -1.70535762401713 0.0627816390070507 no 3116 0.0440638732640471 4597 X1143 SGTC_2484 5809818 12.04 µM -1.70690537600367 0.0626043651479826 no 3117 0.0439198207180511 4562 2870548 SGTC_2147 5545932 89.7195 µM -1.71221711463126 0.0619989441169786 no 3118 0.0434283322939783 4637 797404 SGTC_1921 5740136 50 µM -1.71628584706737 0.0615382960851018 no 3119 0.0430548687014204 4528 1774243 SGTC_2818 7996756 12.99 µM -1.71833677243459 0.0613071127664976 no 3120 0.0428676028804419 4612 2241621 SGTC_1395 3486-0190 4.35 µM -1.72150448291717 0.060951377846412 no 3121 0.0425796597020501 4582 6748079 SGTC_884 0851-0618 334 µM -1.72500114082248 0.0605605780132953 no 3122 0.0422636334613051 4609 9642473 SGTC_75 0159-0059 199.013 µM -1.73096215570192 0.0598988748453562 no 3123 0.0417292572288346 4618 5377270 SGTC_2346 9031566 143.75 µM -1.73110384293419 0.0598832160147358 no 3124 0.0417166225428868 4590 4771086 SGTC_805 3852-0218 479 µM -1.73186211409074 0.0597994687436591 no 3125 0.0416490578257994 4588 6615355 SGTC_112 phenothiazine 287.218 µM -1.73253002669663 0.0597257771522426 no 3126 0.0415896178361485 4568 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_382 3229-0966 23.2 µM -1.74151665378043 0.0587411762589484 no 3127 0.0407965283310721 4623 5722370 SGTC_809 3998-0021 90 µM -1.7462502427959 0.0582276976307982 no 3128 0.0403837389033758 4557 715485 SGTC_2676 harmalol 100 µM -1.75180966284196 0.0576291465093227 no 3129 0.0399032710594245 4584 5459187 A monoamine oxidase inhibitor SGTC_2628 lathosterol 100 µM -1.75452242835631 0.0573388404492101 no 3130 0.0396705151304449 4632 6710616 SGTC_649 1123-0311 367 µM -1.75473414832764 0.0573162317744343 no 3131 0.0396523960460882 4500 693629 YIL048W NEO1 SGTC_1209 2323-2347 50.3 µM -1.75674215409511 0.057102153985799 no 3132 0.0394808844393781 4621 5412760 SGTC_555 4296-0685 37 µM -1.75929829106932 0.0568305499321675 no 3133 0.0392634283618368 4595 2908540 YHR072W ERG7 SGTC_2403 6032726 181.2 µM -1.76185781444455 0.0565596065487857 no 3134 0.0390466618398882 4591 2881040 SGTC_479 n-linoleoylglycine 10 µM -1.76727291009643 0.0559897361344387 no 3135 0.0385912671861012 4644 6433346 An anti-infammatory. SGTC_1678 st019265 80.2 µM -1.76956037410018 0.0557503742469983 no 3136 0.0384002024541198 4594 5367020 SGTC_1389 3405-0187 19 µM -1.7710241527676 0.0555976275657985 no 3137 0.0382783427023325 4601 799890 SGTC_1239 0337-0584 35.4 µM -1.7721691562367 0.055478375789218 no 3138 0.0381832409708581 4650 914301 YML130C ERO1 SGTC_532 1548-0774 215 µM -1.77366723484639 0.0553226563918179 no 3139 0.0380591045855998 4653 5932993 SGTC_1850 st056238 17 µM -1.77685043718228 0.0549929210280593 no 3140 0.0377964254158359 4624 5393177 SGTC_366 0181-0206 4.31 µM -1.78475989150104 0.054180333991336 no 3141 0.0371501358278526 4596 274874 SGTC_748 act1.228 77.9 µM -1.78483952728015 0.0541722010968848 no 3142 0.0371436749193419 4598 4421505 YNR035C ARC35 SGTC_1888 azatryptophan 97.5 µM -1.78876071044175 0.0537729393827516 no 3143 0.0368266804733077 4634 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2211 7117706 200 µM -1.79515576336007 0.0531267873673365 no 3144 0.0363144431385327 4597 822771 SGTC_2401 5128683 200 µM -1.79524861002173 0.0531174517398623 no 3145 0.0363070493862675 4593 708373 SGTC_2492 derrusnin 100 µM -1.79752222360558 0.0528892481059663 no 3146 0.0361263766341491 4652 1715307 Part of coumarin class of compounds. SGTC_109 0132-0036 33.701 µM -1.79768051062584 0.0528733897652365 no 3147 0.0361138258129132 4557 67274 A color developer. SGTC_1210 3013-0140 750 nM -1.80063710905523 0.0525778689593197 no 3148 0.0358800480863853 4647 905973 SGTC_1287 0971-0001 34.6 µM -1.80356988472985 0.0522860259275869 no 3149 0.0356493803398774 4632 4665869 SGTC_2165 5727197 32.143 µM -1.80559497308472 0.0520852594960034 no 3150 0.0354908142318612 4640 1361712 SGTC_1671 st016596 74.5 µM -1.80652767982396 0.0519929975410922 no 3151 0.0354179772642956 4676 2829167 SGTC_1337 1486-1011 40.3 µM -1.81116578218197 0.05153613013267 no 3152 0.0350575966113706 4630 X1337 SGTC_3188 9110789 49.47 µM -1.81141911768678 0.0515112680393348 no 3153 0.0350379994246847 4594 849217 SGTC_3032 9089427 49.47 µM -1.81561556460209 0.0511008188813331 no 3154 0.0347146821723248 4606 17173707 SGTC_64 000l-0018 272.079 µM -1.81698894173778 0.0509670573111189 no 3155 0.0346094032998108 4545 6811119 SGTC_270 tamoxifen 5.46 µM -1.81744434721871 0.0509227641784269 no 3156 0.0345745512654881 4621 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1046 2001-0062 216 µM -1.82332516495366 0.0503535392917224 no 3157 0.0341270785465129 4593 739778 SGTC_2049 5262831 67.185 µM -1.83404155546296 0.0493293107740512 no 3158 0.0333239129307333 4605 763417 SGTC_1115 galangin 695.678 nM -1.83574822017253 0.049167741079718 no 3159 0.0331974513677575 4696 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2450 5739737 12.93 µM -1.83587422610465 0.0491558288905614 no 3160 0.0331881301896138 4650 2262825 SGTC_265 mycophenolic acid 32.932 µM -1.84607598676371 0.0481990109352366 no 3161 0.0324405864977763 4683 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1817 st052116 64.4 µM -1.84745967833125 0.0480703906377106 no 3162 0.0323402734071728 4658 4361398 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.86004083380196 0.0469134792311823 no 3163 0.0314398744912295 4620 1377 SGTC_1605 st000082 49.1 µM -1.86291829753315 0.0466520424343167 no 3164 0.0312368810302143 4624 1114022 SGTC_1024 4507-0395 26 µM -1.87750800525562 0.045344409659481 no 3165 0.0302242505990117 4668 4201836 SGTC_3308 9128332 17.569 µM -1.87898923049822 0.0452133168203677 no 3166 0.0301229818713455 4611 17332805 YDL196W YDL196W SGTC_1130 3454-2858 15.9 µM -1.8791245170615 0.0452013587697318 no 3167 0.0301137466062295 4602 715628 YIL048W NEO1 SGTC_3085 9117376 49.47 µM -1.88415567680931 0.0447584559309414 no 3168 0.02977196046556 4690 16480349 SGTC_1242 0402-0103 60.1 µM -1.88465181076234 0.0447149702433451 no 3169 0.0297384311980303 4582 432868 SGTC_2683 piperine 63.03 µM -1.88611818945596 0.0445866423546566 no 3170 0.0296395148460919 4688 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1228 0124-0032 52.5 µM -1.89034635087089 0.0442182815572883 no 3171 0.0293558267593244 4662 X1228 SGTC_2026 5148700 152 µM -1.89124307475515 0.0441404744313876 no 3172 0.0292959518690347 4649 79838 SGTC_8 0354-0001 70 µM -1.9006678327618 0.0433293640351493 no 3173 0.0286727672181604 4653 4993152 SGTC_2126 5251174 33.877 µM -1.9043748626684 0.0430136469304319 no 3174 0.0284306903051064 4631 790722 SGTC_401 neomycin 50 µM -1.9057364312716 0.0428981537711577 no 3175 0.02834220505615 4658 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3349 9149703 23.001 µM -1.91278321358633 0.0423044190104038 no 3176 0.0278879055037287 4666 4910494 SGTC_1434 4073-0095 163 µM -1.9132251480375 0.0422674059670954 no 3177 0.0278596177052901 4672 24133745 SGTC_2496 diffractaic acid 79.83 µM -1.91849718776305 0.0418278778263675 no 3178 0.0275239991833695 4646 94870 An apoptosis inducer which activates caspases. SGTC_2023 5144124 124 µM -1.9318390943387 0.0407320874527855 no 3179 0.0266896845544942 4639 2830192 SGTC_251 melphalan 456.522 µM -1.93267159789281 0.0406644921986588 no 3180 0.0266383330787198 4701 460612 A DNA alkylator. SGTC_1509 1326-1131 80 µM -1.93530053495421 0.0404516327210451 no 3181 0.0264767133717575 4653 768313 SGTC_888 0916-0002 6.97 µM -1.94366709787256 0.03978022399182 no 3182 0.0259678043708375 4673 2802138 YIL048W NEO1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.94570783106341 0.0396178389838629 no 3183 0.0258449227190207 4687 1273210 SGTC_2215 7188065 200 µM -1.94760770840364 0.0394671470754702 no 3184 0.0257309603548099 4718 940217 SGTC_2078 5212016 200 µM -1.94935476811354 0.0393289879822863 no 3185 0.0256265361241864 4597 1899708 SGTC_1636 st007707 68.9 µM -1.96043141150273 0.0384621684415916 no 3186 0.024972693709635 4678 403051 SGTC_3023 9089636 49.47 µM -1.96898128159547 0.0378037878923846 no 3187 0.0244776203108379 4733 17249241 SGTC_2433 5607874 27.82 µM -1.97176910718182 0.0375911111993776 no 3188 0.0243179852391814 4648 2252428 SGTC_1262 0737-0114 49.6 µM -1.97216615804706 0.0375609007457602 no 3189 0.0242953207870816 4685 765919 SGTC_2761 levamisole 97.89 µM -1.97446292120004 0.0373865354598421 no 3190 0.0241645647790198 4665 26879 An alkaline phosphatase inhibitor. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.97666544497244 0.0372199461956567 no 3191 0.02403972960193 4713 16725076 SGTC_2777 climbazole 1.536 µM -1.97769131591377 0.0371425611045342 no 3192 0.0239817702665822 4468 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.98124901598562 0.0368752092080384 no 3193 0.0237816774173952 4672 16623 A steroid. SGTC_2149 5554786 194.827 µM -1.98131018954231 0.0368706259711662 no 3194 0.0237782491943958 4698 745063 YPR165W RHO1 SGTC_1268 0828-0275 2.46 µM -1.98166663514484 0.036843929665358 no 3195 0.0237582819138973 4705 745337 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.98453171171443 0.0366299208764685 no 3196 0.0235982982581118 4685 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2582 agaric acid 100 µM -1.98937495488749 0.0362704647312158 no 3197 0.0233299159662891 4350 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2102 5377816 72.7585 µM -1.99697732149999 0.0357120597545842 no 3198 0.0229138233208333 4697 1379702 SGTC_763 3453-1109 128 µM -2.00227910543892 0.0353268213394909 no 3199 0.0226273609697281 4702 1560353 SGTC_431 k089-0097 107 µM -2.00608521391506 0.0350523687891642 no 3200 0.0224235785668667 4394 5499420 SGTC_1146 3579-1023 7 µM -2.01634449026838 0.0343212933065812 no 3201 0.0218819828489061 4699 X1146 SGTC_424 splitomicin 100 mM -2.02473450896671 0.0337327772155548 no 3202 0.0214473165527797 4665 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1959 st077091 55.8 µM -2.0295140119964 0.0334012491081563 no 3203 0.0212029816359956 4677 821356 YKL052C ASK1 SGTC_2801 7907800 81.82 µM -2.03294836797893 0.0331646868035129 no 3204 0.0210288698346031 4671 6620925 SGTC_810 3825-7150 143 µM -2.03693807583834 0.0328916060543347 no 3205 0.0208281239443122 4680 22330411 YGL099W LSG1 SGTC_898 1000-0849 28.3 µM -2.03766629386901 0.0328419627927425 no 3206 0.0207916586146743 4691 6751807 SGTC_111 0083-0039 52.457 µM -2.04802637308311 0.0321423728531636 no 3207 0.0202787076533839 4682 759313 SGTC_947 3447-0010 211 µM -2.0515350114016 0.0319082503396797 no 3208 0.0201074368475615 4648 748350 SGTC_804 1595-0054 20.9 µM -2.05153825884227 0.0319080343004023 no 3209 0.0201072788969083 4690 761523 Stimulates phospholipase C. SGTC_1674 st016616 23.6 µM -2.05537066075135 0.0316539205599294 no 3210 0.0199216085371585 4679 625830 SGTC_1344 1488-0097 29.1 µM -2.06021221718453 0.0313352863874461 no 3211 0.0196891287352159 4722 747966 SGTC_726 3448-4391 34.2 µM -2.06215828930837 0.0312079603208977 no 3212 0.0195963341786874 4729 1356692 SGTC_2881 9058953 51.95 µM -2.06230208356693 0.0311985692667261 no 3213 0.0195894923960539 4661 17122249 SGTC_1953 st076800 12.1 µM -2.0642711108257 0.0310702091249121 no 3214 0.0194960092536967 4658 297591 SGTC_107 0358-0022 2.6945 µM -2.06535410508515 0.0309997955956817 no 3215 0.0194447538515769 4714 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1842 st055362 61.2 µM -2.06613633105134 0.0309490194302796 no 3216 0.0194078042983796 4687 676032 SGTC_943 3253-1379 105 µM -2.06642495433475 0.0309303015921649 no 3217 0.0193941858421134 4666 668464 SGTC_2981 9013952 38.96 µM -2.06769176143905 0.0308482572115204 no 3218 0.0193345085559994 4632 2996344 SGTC_2808 7946468 45.46 µM -2.0682707732205 0.0308108177178353 no 3219 0.0193072842255079 4674 2970879 SGTC_2556 citropten 84.59 µM -2.06860859111656 0.0307889914482078 no 3220 0.0192914155494916 4672 2775 A potential DNA crosslinker. SGTC_964 1287-0107 19.4 µM -2.07006134729475 0.030695275327905 no 3221 0.0192232999678881 4688 51516812 YPR165W RHO1 SGTC_2546 rhodinyl acetate 100 µM -2.07034866378167 0.0306767687794732 no 3222 0.0192098527606302 4669 6708682 SGTC_2718 lomofungin 53.02 µM -2.07082038798766 0.0306464042512501 no 3223 0.01918779210214 4659 5351222 A RNA synthesis inhibitor. SGTC_1903 st060211 78.3 µM -2.07408901265521 0.0304366884255075 no 3224 0.0190355224044271 4700 688960 SGTC_3141 9094609 49.47 µM -2.07938419094941 0.0300994724376131 no 3225 0.0187910261938461 4658 25236309 YDL196W YDL196W SGTC_882 0843-0131 351 µM -2.08003832827006 0.0300580304069549 no 3226 0.0187610087292873 4720 5425421 SGTC_2490 carminic acid 95.39 µM -2.08093055454308 0.0300015808401412 no 3227 0.0187201314826444 4689 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1602 st001878 87.6 µM -2.08133461370151 0.0299760456729996 no 3228 0.0187016445087159 4684 595405 YLR310C CDC25 SGTC_1673 st016611 27.3 µM -2.08721335138691 0.0296065637641259 no 3229 0.0184344265624164 4697 5226799 SGTC_1078 idebenone 36.1 µM -2.08775871433816 0.0295724798193637 no 3230 0.0184098027470657 4730 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1384 3089-0840 101 µM -2.08901471173747 0.0294941066983078 no 3231 0.0183531994388496 4694 1069836 SGTC_3165 9101544 49.47 µM -2.09514851262208 0.029113836171996 no 3232 0.0180788962817286 4705 5002184 SGTC_2275 7947463 200 µM -2.09522144949442 0.0291093390076304 no 3233 0.0180756556907312 4667 1225414 SGTC_2698 st077697 67.5 µM -2.09863389711313 0.0288995775370351 no 3234 0.0179245929320187 4671 3154499 SGTC_657 3534-0529 86.7 µM -2.10076479433531 0.02876923069266 no 3235 0.0178308091593684 4717 1049549 SGTC_1556 plumbagin 1.48 µM -2.10630997334417 0.0284323219377343 no 3236 0.0175887177754566 4654 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_522 1273-0010 11.6 µM -2.10679170971464 0.0284032086782756 no 3237 0.0175678192147424 4702 5705015 SGTC_2950 9072895 21.46 µM -2.12159751432587 0.0275204592590099 no 3238 0.0169357756543162 4648 17332245 SGTC_774 k060-0086 136 µM -2.12566709502841 0.0272818703407711 no 3239 0.0167654943062505 4705 5911235 SGTC_589 1227-0070 34.1 µM -2.13717630471737 0.026616438202428 no 3240 0.0162918272669862 4733 2841384 SGTC_2267 7931562 200 µM -2.13903545922304 0.026510229300854 no 3241 0.0162163983514695 4685 934880 SGTC_2916 7875993 68.79 µM -2.16302037532442 0.0251714961214226 no 3242 0.0152698062581842 4643 1299250 SGTC_3079 9117512 49.47 µM -2.16631602879072 0.0249920524289639 no 3243 0.0151435228477599 4765 7185044 SGTC_816 0325-0417 81.3 µM -2.1798767770786 0.0242649355751824 no 3244 0.0146332983895164 4725 68101 SGTC_617 3770-0098 35 µM -2.18717657706073 0.0238809369760155 no 3245 0.0143648180508569 4675 5962639 SGTC_970 1315-0089 19.5 µM -2.18921158123262 0.0237748025745044 no 3246 0.0142907326417781 4716 6811083 YLR033W RSC58 SGTC_2021 4019055 173 µM -2.19032218433539 0.0237170472072445 no 3247 0.014250439525438 4526 44827708 YER133W GLC7 SGTC_2249 haloperidol 116.36 µM -2.19372129309634 0.0235410138823029 no 3248 0.0141277260470294 4656 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_725 1497-0963 19 µM -2.20049906343759 0.0231932856060749 no 3249 0.0138857531574246 4751 3549977 SGTC_3152 9099253 49.47 µM -2.21868027656363 0.0222818074126899 no 3250 0.0132542418950769 4584 25236131 SGTC_624 k048-0052 28 µM -2.21977718723576 0.0222277964314287 no 3251 0.0132169481131251 4733 6835531 SGTC_2560 caryophyllene 100 µM -2.21994826520801 0.0222193826587199 no 3252 0.0132111398264174 4746 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_754 3474-0146 171 µM -2.22932851696945 0.0217621489585998 no 3253 0.0128960272876518 4738 24762078 SGTC_1883 5-benzylidenerhodanine 20 µM -2.23932898829166 0.0212834622169627 no 3254 0.0125672590301244 4731 1273210 SGTC_684 1140-0066 328 µM -2.24118309829049 0.0211956982509693 no 3255 0.0125071086027465 4737 6813534 SGTC_1261 0712-0010 12.7 µM -2.24157200623395 0.0211773282537523 no 3256 0.012494523453436 4714 2840123 SGTC_2285 7945142 200 µM -2.24425603030502 0.0210509157068192 no 3257 0.0124079664240119 4710 2970608 SGTC_110 0850-0284 111.64 µM -2.25354138021111 0.0206185072580004 no 3258 0.0121125173428153 4715 3906265 SGTC_971 1315-0384 26.7 µM -2.25394883287755 0.0205997062367682 no 3259 0.0120996935435475 4741 6769120 SGTC_1572 epiandrosterone 68.9 µM -2.2613414756945 0.0202611026620455 no 3260 0.0118690598878789 4714 441302 A steroid. SGTC_266 formosanin C 406 nM -2.2723906243117 0.0197638240979422 no 3261 0.0115314637472992 4621 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1553 gossypol 38.6 µM -2.28834484322669 0.0190640917662469 no 3262 0.0110587234932046 4723 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3161 9100388 49.47 µM -2.30147375092772 0.0185041809401096 no 3263 0.0106824337121022 4781 25236368 SGTC_3043 9092303 49.47 µM -2.30629940715299 0.018301929768757 no 3264 0.0105469541261333 4730 25236084 SGTC_2697 mebhydrolin 72.4 µM -2.30760891882283 0.0182473719707956 no 3265 0.0105104490035266 4722 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2079 5212404 121 µM -2.32910018869784 0.0173715975224803 no 3266 0.00992687935060379 4713 758462 SGTC_1529 apigenin 74 µM -2.35096817823647 0.0165175722881129 no 3267 0.00936231756147546 4742 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_275 trichlorophene 5.69 µM -2.3539526348972 0.0164038526231378 no 3268 0.00928748888750935 4757 62616 SGTC_2119 5528445 120.635 µM -2.36550531619258 0.0159699479429098 no 3269 0.00900274239405606 4745 791935 SGTC_182 3448-4371 550.524 µM -2.36791734120384 0.0158806074031376 no 3270 0.00894426599412769 4702 3491403 SGTC_1972 st070201 17.4 µM -2.3718473507541 0.015735959247222 no 3271 0.00884970071261532 4753 2829099 SGTC_3130 9127414 49.47 µM -2.3744308314346 0.0156414884047093 no 3272 0.00878801446272934 4755 1494646 SGTC_1950 st077106 7.18 µM -2.39252173866972 0.014993489495873 no 3273 0.00836651840463496 4700 13831864 SGTC_1427 4048-4900 550 nM -2.39763350502093 0.0148146256115919 no 3274 0.00825068320301493 4757 24132586 SGTC_1026 k007-1105 30.6 µM -2.40336563281895 0.0146162403944742 no 3275 0.00812246789036522 4724 7066794 SGTC_3203 9113543 49.47 µM -2.41031591013468 0.0143787658292194 no 3276 0.0079693563460802 4730 17018012 SGTC_1241 0364-0022 50.8 µM -2.41296367066001 0.0142891759941483 no 3277 0.00791169833998694 4752 4563895 SGTC_1211 1056-0033 32.3 µM -2.43882159155055 0.0134392283793577 no 3278 0.00736762052824652 4759 6741922 SGTC_1240 0356-0016 42.1 µM -2.44275138787303 0.013313954896089 no 3279 0.00728788715852699 4729 4305613 SGTC_122 0236-0016 402.397 µM -2.44364113782894 0.0132857320178913 no 3280 0.0072699406045746 4740 6808838 SGTC_3038 9091290 49.47 µM -2.44548686874955 0.0132273501707351 no 3281 0.00723283580866824 4740 25236843 SGTC_2394 5221648 200 µM -2.44647303456547 0.0131962479560839 no 3282 0.00721307941404129 4745 788586 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.44991822351894 0.013088087246346 no 3283 0.00714443312682479 4788 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.46007401071592 0.0127736962876007 no 3284 0.00694541834713076 4752 688669 SGTC_457 grayanotoxin iii 135 µM -2.476138918985 0.0122897192852605 no 3285 0.00664059451277832 4611 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2877 9040724 71.43 µM -2.4852212678751 0.0120231947118946 no 3286 0.00647354663845832 4733 6463895 SGTC_153 4077-0274 519.67 µM -2.49328846165592 0.0117906778076035 no 3287 0.00632829878277414 4753 3121976 SGTC_2077 5212015 200 µM -2.50403436187216 0.0114870208148074 no 3288 0.00613930542798535 4740 780900 SGTC_2858 9025781 8.96 µM -2.50709442426499 0.0114018020053825 no 3289 0.00608640943195052 4624 4894980 YPL153C RAD53 SGTC_610 4215-0184 155 µM -2.51391084672948 0.0112139456324865 no 3290 0.00597003067258079 4765 5605015 SGTC_2131 toluylene red 5.2905 µM -2.52185302435736 0.0109984633194949 no 3291 0.00583692364046911 4725 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1977 st070720 65.3 µM -2.56065141355343 0.00999680942908312 no 3292 0.00522380630122024 4767 682188 SGTC_3197 9113331 49.47 µM -2.56508326616217 0.00988762313871522 no 3293 0.00515755239037975 4735 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2080 5212524 12.4 µM -2.56521960767614 0.00988428070677071 no 3294 0.00515552606621738 4743 260183 SGTC_1385 3091-4834 14.1 µM -2.60357535984795 0.00898229363297048 no 3295 0.00461284914975854 4753 4072814 SGTC_2675 theaflavin digallate 100 µM -2.63192181041672 0.00836283717975023 no 3296 0.00424517000462656 4740 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_688 0527-0193 473 µM -2.67523935209719 0.00748862848647457 no 3297 0.00373379574860755 4781 4007154 SGTC_1745 st081495 74 µM -2.69125125407008 0.00718647488790378 no 3298 0.00355922805168132 4695 13842402 YBL026W LSM2 SGTC_1111 tnp00062 510.699 nM -2.71447859946013 0.00676727989546858 no 3299 0.00331900945193357 4752 676306 SGTC_1244 0416-0015 52.5 µM -2.72569507190661 0.00657269899711159 no 3300 0.00320831236286737 4769 96201 SGTC_1956 st077085 54 µM -2.73704699840802 0.00638082200397422 no 3301 0.00309967177951834 4775 24208685 SGTC_1266 0828-0227 32.9 µM -2.76956278451579 0.00585837671238002 no 3302 0.00280657923878095 4756 3913820 SGTC_1144 3486-0183 12.5 µM -2.77113833997449 0.00583405429053884 no 3303 0.0027930344186023 4792 6744069 SGTC_1555 citronellol 128 µM -2.77380110869841 0.00579315175410475 no 3304 0.00277027700442669 4781 8842 A terpine precursor. SGTC_328 k915-0120 63.5 µM -2.78100320877155 0.00568379304972141 no 3305 0.00270956007630295 4795 6624543 SGTC_2164 5685496 200 µM -2.80009162962888 0.00540276430426082 no 3306 0.00255440513357131 4777 759046 SGTC_374 0880-0231 82.3 µM -2.80032544575218 0.00539939992421163 no 3307 0.00255255545373303 4714 6833587 SGTC_983 1491-0821 12.2 µM -2.81698415424104 0.00516443911609887 no 3308 0.0024238458651773 4780 46495113 SGTC_514 4466-0038 2.65 nM -2.83577710491881 0.00491033613957335 no 3309 0.00228571691302472 4684 5722064 SGTC_1134 3477-0009 42.5 µM -2.85435819260835 0.00467011180952513 no 3310 0.00215619395993133 4760 3973534 SGTC_3337 9144342 33.5465 µM -2.85459835466455 0.00466707676116222 no 3311 0.00215456433105403 4777 17682949 SGTC_609 0986-0026 86.3 µM -2.90658080441934 0.00405012484671409 no 3312 0.00182701255096128 4773 2848610 SGTC_966 1300-0360 30.2 µM -2.91480925905485 0.00395946187665839 no 3313 0.00177952995388012 4781 70588 SGTC_1158 4092-0494 91.8 µM -2.92345645741801 0.00386614793708171 no 3314 0.00173084318841718 4798 1148199 SGTC_427 1354-0053 47.3 µM -2.92425743124779 0.00385760496857342 no 3315 0.00172639534111093 4781 6813657 SGTC_304 1310-0298 97 µM -2.95438022432449 0.00354835559704206 no 3316 0.00156648870916716 4641 1550234 SGTC_2701 st077767 14.721 µM -2.95458366103432 0.00354634499520729 no 3317 0.00156545625913093 4782 5721188 SGTC_1131 3454-3128 32.3 µM -2.96492316098722 0.00344549522963653 no 3318 0.00151379269938661 4769 710982 SGTC_1658 st012944 20 µM -2.9725901366776 0.0033723845003669 no 3319 0.00147649244685311 4717 24207260 SGTC_44 0929-0055 61.211 µM -2.98583284597093 0.00324938269751315 no 3320 0.0014140359104841 4673 1379590 SGTC_1628 st004252 77.7 µM -2.99041782057481 0.00320774610929982 no 3321 0.00139298041163776 4786 692968 SGTC_660 4031-1742 102 µM -2.99403957867841 0.00317519661443221 no 3322 0.0013765511437894 4739 6738706 SGTC_601 0986-0029 62.9 µM -2.99471142659688 0.00316919136440869 no 3323 0.00137352299553862 4770 24747981 SGTC_3097 9117246 49.47 µM -3.04407372392703 0.00275496573416422 no 3324 0.00116698968158424 4797 16423892 SGTC_1989 st071868 50.2 µM -3.06523884464224 0.00259283719404857 no 3325 0.00108748115212482 4797 16414057 SGTC_2117 5521686 200 µM -3.12249457130892 0.00219655012328802 no 3326 0.000896627063203337 4793 803312 SGTC_1206 3978-0017 132 µM -3.15986812897199 0.00196837716082596 no 3327 0.00078920280638726 4786 3873677 SGTC_1934 st074720 32.6 µM -3.21073975006504 0.00169236167389532 no 3328 0.000661968886617145 4772 17250992 SGTC_92 0063-0024 660.874 µM -3.22372242761623 0.00162781061140598 no 3329 0.000632679932687594 4798 3594437 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -3.2652342067934 0.00143617483860002 no 3330 0.000546868000970003 4773 6708739 YPR165W RHO1 SGTC_3088 9117578 49.47 µM -3.27072526578764 0.00141243013722709 no 3331 0.000536360343647561 4806 678341 SGTC_326 k292-0812 17.5 µM -3.27360115528215 0.00140013763067388 no 3332 0.000530931880475055 4804 3579357 SGTC_2795 7780010 54.55 µM -3.32008700887396 0.00121453051703326 no 3333 0.000449946982754467 4785 953673 SGTC_1547 harmine 94.2 µM -3.33501146959821 0.00115989752835792 no 3334 0.000426479405406402 4767 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -3.33520607257187 0.0011592002649091 no 3335 0.000426181044766812 4777 676296 Flavone; oxidizing agent. SGTC_3098 9119039 49.47 µM -3.381555684796 0.00100364960187304 no 3336 0.0003603831131211 4798 17161528 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -3.46790026823863 0.000763846517380278 yes 3337 0.000262270960148117 4777 6728940 SGTC_255 tunicamycin 200.472 nM -3.60611076843009 0.000487264029109419 yes 3338 0.000155410250902818 4791 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1005 4092-0690 4.4 µM -3.67187207099772 0.000391300516214644 yes 3339 0.000120390105228206 4800 1529343 SGTC_612 0302-0167 22.4 µM -3.67544981580933 0.000386620128572109 yes 3340 0.000118715355550778 4799 235821 SGTC_2526 patulin 37.61 µM -3.68465518710555 0.000374815533719309 yes 3341 0.000114506229763826 4804 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2082 5219693 150 µM -3.7813054950583 0.000269538315601849 yes 3342 7.80040438421558e-05 4797 2834649 SGTC_1113 artemisinin 1.17947 µM -3.87809244392377 0.000192271474090829 yes 3343 5.26393573752776e-05 4809 2240 An anti-malaria and mitochondrial poison. SGTC_1510 1123-0200 71.5 µM -3.89257595010748 0.000182673818476626 yes 3344 4.95927168023951e-05 4804 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3018 9082602 49.47 µM -3.91805713409544 0.000166867278261562 yes 3345 4.46327754827762e-05 4758 17332089 SGTC_690 glyoxal 20.3 µM -4.04257657219881 0.000106411108728914 yes 3346 2.64335198627593e-05 4775 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2330 7979373 200 µM -4.12203126178111 7.93298318652407e-05 yes 3347 1.87773110302701e-05 4795 1863007 SGTC_568 1193-0097 7.48 µM -4.21874198443584 5.51002317297413e-05 yes 3348 1.22834605473431e-05 4771 3646150 SGTC_2878 9043973 25.97 µM -4.2878074519819 4.22742696421157e-05 yes 3349 9.02227012647355e-06 4791 6465167 SGTC_2250 alverine citrate 130 µM -4.49716318513873 1.84856955638661e-05 yes 3350 3.44330662937984e-06 4779 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1161 k007-0610 110 µM -4.81306229872385 4.9549760299255e-06 yes 3351 7.43174645591226e-07 4799 5843850 SGTC_2874 9043904 71.43 µM -4.9810562080843 2.37873472622096e-06 yes 3352 3.16190835269579e-07 4794 4463428 SGTC_606 k015-0008 38.6 µM -5.07591705239077 1.55558280907309e-06 yes 3353 1.92815753712024e-07 4810 1970475 SGTC_3037 9091026 49.47 µM -6.20275635041981 5.64016643118872e-09 yes 3354 2.77413520688406e-10 4806 25236398 YIL048W NEO1 SGTC_453 enantio-paf c16 10 µM -6.61745064736279 5.45332364788931e-10 yes 3355 1.82723080738159e-11 4743 13871343 A lipid and platelet activating factor