SGTCid condition conc unit HIS5|YIL116W.score HIS5|YIL116W.strain.pval HIS5|YIL116W.strain.significant HIS5|YIL116W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_419 nsc-638432 893 µM 9.13016322200588 5.38317236048346e-21 yes 1 3.41980480089433e-20 1 368090 SGTC_1908 st060353 56.5 µM 7.61472095417472 3.70130433059251e-15 yes 2 1.32130878283445e-14 4 4227716 SGTC_2355 9061122 103.12 µM 6.97828083477992 5.1621757955058e-13 yes 3 1.49406949812448e-12 2 5302957 SGTC_1212 0520-0165 585 µM 6.02433694698664 3.8765169988468e-10 yes 4 8.49021444824662e-10 5 5403258 SGTC_2582 agaric acid 100 µM 5.88908371146373 9.19112672951913e-10 yes 5 1.94171356060618e-09 163 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2818 7996756 12.99 µM 5.14021945178573 7.80776457279562e-08 yes 6 1.37208887291271e-07 6 2241621 SGTC_1990 st072050 59.8 µM 4.79464271577448 5.00333364537342e-07 yes 7 8.1482506656521e-07 5 17233948 SGTC_2037 5169046 200 µM 4.59371708229282 1.39371606564789e-06 yes 8 2.1770980621747e-06 7 5718022 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 4.56138151053009 1.63727546223383e-06 yes 9 2.54090752696819e-06 6 688803 SGTC_898 1000-0849 28.3 µM 4.25466087901367 7.15916219807195e-06 yes 10 1.04683041416188e-05 3 6751807 SGTC_394 menadione 8.33 µM 4.21447726428736 8.62506125938446e-06 yes 11 1.25178684898917e-05 23 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_456 gingerol 170 µM 4.15124020735017 1.15252343039126e-05 yes 12 1.65339239349071e-05 16 442793 A herb. SGTC_2804 7954240 19.48 µM 4.04640414619842 1.84720414011457e-05 yes 13 2.60052037736914e-05 28 828705 SGTC_2480 5767542 37.17 µM 4.0142994951102 2.12959216637294e-05 yes 14 2.98113009459916e-05 10 2867358 SGTC_2114 5491910 81.25 µM 3.98050662003151 2.47083189152562e-05 yes 15 3.43842747643985e-05 11 2849228 SGTC_1711 st032263 62.8 µM 3.94607785102678 2.87140744320803e-05 yes 16 3.97208966506854e-05 17 3958979 SGTC_2160 5660466 132.927 µM 3.86952839796222 3.99332168752551e-05 yes 17 5.45230399873229e-05 17 2859134 SGTC_2953 9074162 66.49 µM 3.86242105916507 4.11627841226878e-05 yes 18 5.61344243799141e-05 26 16451992 SGTC_1453 4237-0541 195 µM 3.64007965257799 0.000103631108882139 yes 19 0.000136276857314101 34 739892 SGTC_401 neomycin 50 µM 3.50960143245575 0.000174130802624091 yes 20 0.000224389424988106 17 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_690 glyoxal 20.3 µM 3.49061255285317 0.000187528061198308 yes 21 0.000240957287283702 104 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1522 st012842 45.6 µM 3.39495273298226 0.000270943419221829 yes 22 0.000343202248797065 48 3491067 YOR116C RPO31 SGTC_717 1532-0246 73.2 µM 3.39162330642049 0.000274391207211223 yes 23 0.000347399458278594 57 9561992 SGTC_778 3456-2434 196 µM 3.34542990544034 0.000326642055577624 yes 24 0.000410775609268598 107 5539063 SGTC_2651 TUB2.036 5 µM 3.32823526163393 0.00034835134195284 yes 25 0.000436990134895575 211 15992207 YFL037W TUB2 SGTC_1101 ebselen 5.29 µM 3.29478773352782 0.00039447137776773 yes 26 0.000492480251314642 46 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1129 3453-1384 223 µM 3.27661064863731 0.000421852119771393 yes 27 0.000525305688536746 70 1084452 SGTC_2649 anisomycin 9.56 µM 3.21323964295804 0.000531697738673842 yes 28 0.000656233654894578 25 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2831 7999036 19.48 µM 3.20940669469538 0.000539124189759834 yes 29 0.000665046043147566 83 2988270 SGTC_1989 st071868 50.2 µM 3.20638812650679 0.000545040162381512 yes 30 0.000672062791996056 32 16414057 SGTC_2218 6965428 192.983 µM 3.1319655446579 0.00071130806275663 yes 31 0.000868201259171968 24 675684 SGTC_2487 5918373 44.05 µM 3.12937223809972 0.000717867696912617 yes 32 0.000875901172580417 46 2876279 SGTC_2421 5690543 90.72 µM 3.0762256617783 0.000865200731136356 yes 33 0.00104819559421935 52 3397993 SGTC_3187 9109394 49.47 µM 3.06287599495562 0.000906343072135206 yes 34 0.00109610441163112 72 17098090 SGTC_73 0327-0325 16.231 µM 3.06188073831041 0.000909481250465829 yes 35 0.00109975534123498 108 53298 SGTC_1622 st003707 19.4 µM 3.04058646680423 0.000979063586859059 yes 36 0.00118058941549219 92 10140899 SGTC_2996 9066192 71.4286 µM 2.96368018715989 0.00127304442606961 no 37 0.00151992016850071 89 6472854 SGTC_2105 5350118 200 µM 2.9206215140443 0.00147094318437003 no 38 0.00174666968154506 76 2133313 SGTC_896 0964-0007 44.5 µM 2.88278752873279 0.0016675836540591 no 39 0.00197086607559721 43 6756758 SGTC_2453 5731132 22.18 µM 2.87272813096223 0.00172375047650936 no 40 0.00203472074316901 87 1362040 SGTC_1916 st067606 49.2 µM 2.86683281242698 0.00175746202168923 no 41 0.00207300986433858 110 19590279 SGTC_2925 9010536 32.5 µM 2.82514515774284 0.00201348676753023 no 42 0.00236296004567443 117 2994177 SGTC_3162 9099653 49.47 µM 2.8120567733837 0.00210059054751332 no 43 0.00246129069360776 38 25237511 SGTC_1100 amiodarone 5.07 µM 2.78330199949953 0.00230407397340971 no 44 0.00269043472233283 62 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2352 9027995 87.8 µM 2.7825240817751 0.00230981886397362 no 45 0.00269689311133944 81 2997347 SGTC_2485 5633444 17.78 µM 2.76308654783957 0.00245764165304184 no 46 0.00286287908895736 114 5724239 SGTC_1529 apigenin 74 µM 2.75979610976721 0.00248349585158813 no 47 0.00289187228946144 103 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3063 1327-0034 4 µM 2.75080477081655 0.00255540325916624 no 48 0.00297245309421656 101 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1901 st060216 58.6 µM 2.73188249337746 0.00271291399695635 no 49 0.00314867982545832 86 688792 SGTC_2483 5729050 27.16 µM 2.71807757154869 0.0028333011833338 no 50 0.00328312209198753 104 2865180 SGTC_695 3505-6186 243 µM 2.7124297145012 0.00288392764066629 no 51 0.00333959721452677 78 1819379 SGTC_3177 9107506 49.47 µM 2.70952662984599 0.00291026654231437 no 52 0.00336896479897702 49 8897194 SGTC_2273 7815444 169.05 µM 2.68000316501887 0.00319070279503322 no 53 0.00368107320381068 89 2824616 SGTC_2332 7982454 138.89 µM 2.6787612182948 0.00320301564274379 no 54 0.0036947534480492 145 2981748 SGTC_2048 5246248 200 µM 2.67323529396718 0.0032583203905122 no 55 0.00375617690416509 51 677046 SGTC_514 4466-0038 2.65 nM 2.67051782582986 0.00328583124224088 no 56 0.00378671750807425 260 5722064 SGTC_1635 st007035 42.4 µM 2.65393807446823 0.00345825172061858 no 57 0.00397792129213852 336 3716403 SGTC_2622 2-methoxyxanthone 59.94 µM 2.65077714116989 0.00349203152388413 no 58 0.00401534057476914 84 71034 A hepatoprotective. SGTC_1221 2958-7315 257 µM 2.63399690944716 0.00367636748697636 no 59 0.0042193128020266 86 4562705 SGTC_266 formosanin C 406 nM 2.58712850010509 0.00423833801040545 no 60 0.00483897464488066 173 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1921 5740136 50 µM 2.5610451020326 0.00458330869804844 no 61 0.00521789036633922 174 1774243 SGTC_1993 st073995 70.8 µM 2.54930536591488 0.00474659432639562 no 62 0.00539688710649974 93 3098394 SGTC_1301 naphtanilide LB 4.81 µM 2.54578747364023 0.00479652411212612 no 63 0.00545157734404729 85 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1859 st055998 20 µM 2.54247706216068 0.00484393622021357 no 64 0.00550349127857284 98 676301 SGTC_1575 cyproterone acetate 48 µM 2.53744990746142 0.00491673479412612 no 65 0.00558316735671739 120 9880 An androgen receptor antagonist and liver toxin. SGTC_1605 st000082 49.1 µM 2.53376858549363 0.00497066097812873 no 66 0.00564216128948645 104 1114022 SGTC_1112 tnp00069 1.16933 µM 2.5099441205881 0.00533257264870156 no 67 0.00603751338753683 120 145826 SGTC_2002 4023503 131 µM 2.48782166343764 0.00568941732600822 no 68 0.00642640827033004 155 4736863 YCR052W RSC6 SGTC_1419 3993-2473 62.6 µM 2.47806696477161 0.00585338893571777 no 69 0.0066048175212119 107 704026 SGTC_3180 9109287 49.47 µM 2.47567472353767 0.00589423593382638 no 70 0.00664923371208171 107 18891271 SGTC_3185 9108267 49.47 µM 2.46143321341755 0.00614267997257604 no 71 0.00691915796962941 136 4910486 SGTC_66 0109-0187 42.4 µM 2.44192739776026 0.0064980006960864 no 72 0.00730454213873314 134 759417 SGTC_1877 wortmannin 25 µM 2.42386718106108 0.0068430739660951 no 73 0.00767811031874068 221 312145 A covalent inhibitor of PI 3-kinase. SGTC_885 0865-0106 16.8 µM 2.41992532884296 0.00692050766515159 no 74 0.00776184723041382 151 2793380 SGTC_894 0960-0238 55.9 µM 2.41936756644725 0.00693152659403722 no 75 0.00777376046725448 86 6741907 YDL195W SEC31 SGTC_2152 5568786 200 µM 2.41613171864712 0.00699575883519662 no 76 0.00784319283532617 112 5399883 SGTC_2337 9009472 200 µM 2.39326904847796 0.00746474854514159 no 77 0.0083494953729825 169 5742383 SGTC_789 1309-1135 70.6 µM 2.39143598962699 0.00750352347080298 no 78 0.00839130506562557 160 3092424 SGTC_2917 7979103 53.79 µM 2.38521167804708 0.00763651438364242 no 79 0.00853464827472858 160 2980565 SGTC_1873 rapamycin 2 nM 2.38331799927722 0.00767738505414391 no 80 0.00857868303867318 209 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_904 1141-0088 396 µM 2.37998278372716 0.00774983633318191 no 81 0.00865672346101544 120 1378119 SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.37971846489492 0.00775560381119617 no 82 0.00866293477866741 162 165506 SGTC_714 4296-0578 26.1 µM 2.32525764409501 0.00902755525562744 no 83 0.010029093836877 47 1589775 SGTC_705 1124-0212 310 µM 2.31869876731236 0.00919244043747429 no 84 0.0102056877092349 139 9554485 SGTC_728 3030-5151 22.5 µM 2.30417458721052 0.00956697743082668 no 85 0.0106064225699945 112 3125388 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.30288950412103 0.00960074960748117 no 86 0.0106425304266204 154 5024745 SGTC_546 peri-Naphthalide 147 µM 2.3003319331602 0.00966827314006778 no 87 0.0107147109270001 135 223824 A penicillin ester. SGTC_2889 9059656 51.95 µM 2.28317279288411 0.0101321243426529 no 88 0.0112100960349043 116 3949838 SGTC_1429 4049-0205 9.46 µM 2.2739708565705 0.0103887825186904 no 89 0.0114838694154429 147 22774478 SGTC_1116 jasmonic acid  1.58368 µM 2.2739186230905 0.0103902554316927 no 90 0.0114854398820794 150 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2526 patulin 37.61 µM 2.26374851442704 0.010680529376281 no 91 0.01179479338135 280 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3289 9119912 71.43 µM 2.25968119995815 0.0107985803543221 no 92 0.0119205219644119 170 17014829 SGTC_3059 1327-0034 3 µM 2.25422710809626 0.0109586634227614 no 93 0.0120909421249736 199 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_58 0957-0393 9 µM 2.23680395363278 0.0114839626458547 no 94 0.012649578021213 623 6997992 SGTC_1302 1159-0335 255 µM 2.23322828777479 0.0115944318298211 no 95 0.0127669468966894 131 649284 SGTC_1449 4112-4002 201 µM 2.2202832551527 0.0120021173739245 no 96 0.0131997729334294 142 2059539 SGTC_1374 2889-5571 141 µM 2.19647649279541 0.0127843989563882 no 97 0.0140289279538597 219 2853281 SGTC_1292 0kpi-0043 232 µM 2.17821030382436 0.0134141655325265 no 98 0.0146951916547786 158 3333905 SGTC_1171 0368-0077 21.4 µM 2.17329716592392 0.0135880612864845 no 99 0.0148789793323625 143 3239779 SGTC_2627 acetyl isogambogic acid 100 µM 2.17022001166088 0.0136979621820648 no 100 0.0149950913921455 205 6857789 A caspase activator and apoptosis inducer. SGTC_1000 4048-0884 8.67 µM 2.16696396605945 0.0138150864257274 no 101 0.0151188009110265 190 13040088 SGTC_156 3474-0145 5.642 µM 2.16499542948613 0.0138863154116599 no 102 0.0151940176445714 218 2265471 SGTC_810 3825-7150 143 µM 2.15905632724098 0.0141031363685186 no 103 0.0154228986362316 141 22330411 YGL099W LSG1 SGTC_2047 4141938 200 µM 2.15127890350842 0.0143914765578693 no 104 0.0157270961936154 135 3807862 SGTC_679 0422-0091 41.4 µM 2.14885660362218 0.0144823113361663 no 105 0.0158228843849923 218 627384 YHR062C RPP1 SGTC_2563 tomatine 8.54 µM 2.1372878376195 0.0149229708131258 no 106 0.016287293738102 251 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2618 avocadyne 43.43 µM 2.13339607963033 0.0150737782359093 no 107 0.0164461241963273 170 3015189 SGTC_851 0394-0702 453 µM 2.1315049693096 0.0151475312481265 no 108 0.0165237817468361 169 762646 SGTC_876 0720-0963 56.8 µM 2.12486864317348 0.0154088051028326 no 109 0.0167987875495987 171 765861 SGTC_809 3998-0021 90 µM 2.12432364539556 0.0154304327067437 no 110 0.0168215449148331 144 715485 SGTC_2304 7443016 91.4 µM 2.12029887532713 0.0155909593830112 no 111 0.0169904242305072 148 939854 SGTC_1382 3002-2117 298 µM 2.11152178513152 0.0159460074599289 no 112 0.0173637437165071 173 1497314 SGTC_2004 4023728 41.89 µM 2.10803595397774 0.0160889262734741 no 113 0.0175139397850649 219 360084 YDR527W RBA50 SGTC_2569 tetrandrine 100 µM 2.10290778174723 0.0163011756007123 no 114 0.0177369157354145 179 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1322 1348-1070 12 µM 2.0982320745094 0.01649678353619 no 115 0.0179423247685624 124 6758089 SGTC_676 falcarinol 140 µM 2.09183457387547 0.0167676755226671 no 116 0.0182266581985679 222 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1618 st003135 44.5 µM 2.0605934353983 0.018145833473337 no 117 0.0196709217825842 167 1270615 SGTC_2228 7354201 200 µM 2.05778575094821 0.0182742890767471 no 118 0.0198053522405639 128 753451 SGTC_2921 7974240 10.71 µM 2.05234098645308 0.0185256038999372 no 119 0.020068267692887 237 2979074 YDR527W RBA50 SGTC_3160 9100216 49.47 µM 2.05204604530712 0.0185393011611598 no 120 0.0200825938666358 140 17191039 SGTC_1693 xanthone 101.9 µM 2.04502405861275 0.018867962480699 no 121 0.0204262431342377 208 7020 An insecticide. SGTC_1498 4478-3555 97.6 µM 2.0436495515022 0.0189328725307299 no 122 0.0204940901709748 124 3437919 SGTC_1825 st052143 62.6 µM 2.0409020539949 0.0190631904486896 no 123 0.0206302818115737 164 674173 SGTC_1690 st023502 41.2 µM 2.02985522289003 0.0195948835713308 no 124 0.0211856288615972 181 24207482 SGTC_350 k064-0020 19.8 µM 2.02849463917326 0.0196612324627449 no 125 0.0212548949434521 242 2790705 SGTC_23 0213-0011 39.996 µM 2.02490625186024 0.0198371358087196 no 126 0.0214384957645225 213 627608 SGTC_774 k060-0086 136 µM 2.01026023535984 0.0205689999462915 no 127 0.0222018265764294 239 5911235 SGTC_2182 6325192 200 µM 1.99863905961068 0.0211658709472301 no 128 0.0228237105030686 184 736248 SGTC_1131 3454-3128 32.3 µM 1.98939052239211 0.0216512920569766 no 129 0.0233290574715004 269 710982 SGTC_1276 0871-0068 94.2 µM 1.98724973792759 0.0217649848024824 no 130 0.0234473642624505 190 3414906 SGTC_872 0588-0139 234 µM 1.97415145976693 0.0224716436943048 no 131 0.0241822617334317 253 2047100 SGTC_2277 7947813 106.88 µM 1.97095388916925 0.0226470627486035 no 132 0.0243645751516014 245 1246798 SGTC_2981 9013952 38.96 µM 1.96971408152564 0.0227153885800287 no 133 0.0244355741070493 247 2996344 SGTC_2852 9023854 51.95 µM 1.96728585888582 0.0228497114092211 no 134 0.0245751322000052 220 19798528 SGTC_378 3970-0959 8.33 µM 1.96716493851046 0.0228564178591901 no 135 0.0245820993473032 220 6615653 SGTC_341 1486-1430 230 µM 1.95862710339029 0.0233341510008568 no 136 0.0250782365432848 240 2054753 YPL210C SRP72 SGTC_775 4577-0580 57.3 µM 1.95667845551808 0.0234443573427126 no 137 0.0251926422228953 206 2006902 SGTC_2054 5233173 129 µM 1.94357683734616 0.0241967494912287 no 138 0.0259732506274776 301 6889 SGTC_2893 9048488 25.97 µM 1.94090122492619 0.0243528711405019 no 139 0.0261351297083033 215 6467338 SGTC_1740 st038286 13.222 µM 1.93965374961353 0.0244259497537147 no 140 0.0262108919713913 259 716786 SGTC_1979 st071809 45.3 µM 1.93829303844818 0.0245058716884014 no 141 0.0262937406277571 211 4976333 SGTC_2800 7887935 81.82 µM 1.93091998307967 0.0249427573560846 no 142 0.0267464742721395 233 2961002 SGTC_1260 0700-1617 7.75 µM 1.92986138253125 0.0250060169895364 no 143 0.026812007714154 279 2853078 SGTC_2266 7929956 200 µM 1.92734724912484 0.025156795283791 no 144 0.0269681844569639 252 2967153 SGTC_2844 9010103 25.97 µM 1.91862145309622 0.0256860247389833 no 145 0.0275161292814581 266 2480525 SGTC_2283 7944793 200 µM 1.91276801925015 0.0260462398712963 no 146 0.0278888785038485 280 2970533 SGTC_1474 0330-0125 5.35 µM 1.89765057983354 0.026996144587632 no 147 0.0288710633800348 233 X1474 SGTC_2287 7945887 168.79 µM 1.89641469818065 0.0270750636784491 no 148 0.0289526149107208 233 1245853 SGTC_150 3970-0969 77.2 µM 1.89540523691483 0.0271396671186588 no 149 0.0290193677172501 347 6615640 SGTC_2214 7179297 48.276 µM 1.89284982069994 0.0273037836063115 no 150 0.0291889219808255 175 769744 SGTC_1634 st006576 41 µM 1.85880302756732 0.0295704690105447 no 151 0.0315275315894422 261 3915356 SGTC_2584 androsterone 48.74 µM 1.85818967248666 0.0296126940456533 no 152 0.0315710420413349 438 2754130 A steroid. SGTC_1821 st053465 65.6 µM 1.85778289543228 0.0296407252756024 no 153 0.0315999255334677 214 675086 SGTC_657 3534-0529 86.7 µM 1.85541987488776 0.0298039981498728 no 154 0.0317681457032499 262 1049549 SGTC_919 tnp00227 403.569 nM 1.85469206443281 0.0298544362412286 no 155 0.0318201063087854 303 1269246 A methoxyflavone. YNL221C POP1 SGTC_893 0958-0369 48.9 µM 1.84724886678909 0.0303743344409224 no 156 0.0323555400026036 309 6819948 SGTC_2899 9053889 58.44 µM 1.83659129606078 0.0311317939851043 no 157 0.033135126605034 208 6470052 SGTC_3323 9138564 53.9225 µM 1.83261642434701 0.0314182694986544 no 158 0.0334298169466483 299 43912313 YNL103W MET4 SGTC_1864 st057645 30.4 µM 1.83081885282023 0.0315485372785932 no 159 0.0335637927097623 217 688666 SGTC_571 k831-0106 44.2 µM 1.82321260365557 0.0321047033269384 no 160 0.0341355984473416 245 4783639 SGTC_757 1066-0008 322 µM 1.79877643331001 0.0339464860825763 no 161 0.0360270263285392 293 6842497 SGTC_2260 7964312 200 µM 1.79573357288613 0.0341817972363204 no 162 0.0362684498725422 241 231951 SGTC_949 1165-0505 146 µM 1.79361693132024 0.034346271334964 no 163 0.0364371661032882 317 6244267 SGTC_1998 st075797 76.8 µM 1.79360365933235 0.0343473046859106 no 164 0.0364382260282993 316 24208315 SGTC_1651 st011928 86.1 µM 1.79261583200665 0.034424288222556 no 165 0.0365171865646491 250 720198 SGTC_654 1124-0271 80.9 µM 1.77264922859122 0.0360109612785744 no 166 0.0381434244809489 331 5403748 SGTC_1032 k061-1018 98.7 µM 1.77256872978306 0.0360174774462332 no 167 0.0381500985688417 340 4005393 SGTC_1163 k060-0048 49.9 µM 1.77255915270137 0.0360182527501877 no 168 0.0381508926599527 329 6809982 SGTC_2411 st077133 39.94 µM 1.77189100652537 0.0360723756679287 no 169 0.0382063258003014 344 1403142 YNL221C POP1 SGTC_3345 9148410 3.559 µM 1.77087944497476 0.036154443547296 no 170 0.0382903755813234 240 4903596 SGTC_3060 1327-0027 12.5 µM 1.77021304737867 0.0362085917985885 no 171 0.0383458283134743 273 16000455 YPR107C YTH1 SGTC_929 2805-0021 398 µM 1.768215747603 0.0363712805709994 no 172 0.0385124212721299 288 3098024 SGTC_2988 9073640 71.4286 µM 1.76528763786132 0.0366108688849553 no 173 0.0387577180479194 284 9102229 SGTC_2346 9031566 143.75 µM 1.76329965208728 0.0367742676073986 no 174 0.0389249819827857 264 4771086 SGTC_1381 2324-0066 62.1 µM 1.7611137734303 0.0369546196626117 no 175 0.0391095741324077 338 10885928 SGTC_2097 5376186 200 µM 1.75658663908451 0.0373304433745276 no 176 0.0394941459887826 319 742755 SGTC_2026 5148700 152 µM 1.75433683262803 0.037518370986304 no 177 0.0396864040281843 290 79838 SGTC_113 0099-0221 2.5 µM 1.75431067846479 0.0375205601926997 no 178 0.0396886435087111 283 89219 SGTC_2977 9011197 71.43 µM 1.73665899420555 0.039022042179136 no 179 0.0412236898727281 242 2704722 SGTC_2593 nobiletin 86.24 µM 1.73214740980217 0.0394135554018227 no 180 0.0416236599014496 271 72344 An anti-infammatory. SGTC_3240 9133527 49.47 µM 1.72965433137022 0.0396312708307988 no 181 0.0418460263334466 286 17617455 SGTC_841 0251-0215 91.2 µM 1.72805803613475 0.0397711848837453 no 182 0.0419889099704061 387 3888614 SGTC_762 1165-0429 115 µM 1.72637090001633 0.0399194973071123 no 183 0.0421403537642848 313 5967793 SGTC_104 0074-0074 590.992 µM 1.72490979289146 0.0400483029510212 no 184 0.0422718652342798 177 3943124 SGTC_2046 4110841 106 µM 1.71693348173584 0.0407574300355287 no 185 0.0429956632344555 305 44119630 YMR134W ERG29 SGTC_802 4112-3352 742 µM 1.70965178356599 0.0414136675678705 no 186 0.0436651419004999 358 704594 SGTC_1256 0570-0116 285 µM 1.6957816491837 0.0426873436860103 no 187 0.0449636195059673 299 410638 SGTC_2419 paclitaxel 166.5 µM 1.69040486293287 0.043189526650675 no 188 0.0454752626777093 421 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1810 st050138 53 µM 1.68131897447581 0.044048968753654 no 189 0.0463504871284509 258 3444541 SGTC_2320 7373003 200 µM 1.67827579960266 0.0443398893356053 no 190 0.0466466350766913 327 5415828 SGTC_3156 9099931 49.47 µM 1.67218365905879 0.0449269361777096 no 191 0.0472440558757873 321 18111053 SGTC_2701 st077767 14.721 µM 1.6693542487455 0.045201701584081 no 192 0.0475235975026342 388 5721188 SGTC_69 0096-0274 206.684 µM 1.66615957382067 0.0455135614138701 no 193 0.0478408177386345 414 6741392 SGTC_2243 6634756 200 µM 1.66369048704779 0.0457557737193941 no 194 0.0480871491603836 287 885676 SGTC_3191 9110352 49.47 µM 1.65859693221821 0.0462587138213098 no 195 0.04859852019266 290 17122424 SGTC_2375 9072683 200 µM 1.65668179141744 0.0464489602473367 no 196 0.048791913123646 372 16798029 SGTC_1852 st056254 31.4 µM 1.65463615842611 0.0466528626852907 no 197 0.0489991621304126 318 442583 SGTC_2992 9074591 71.4286 µM 1.6494309567546 0.047174941123003 no 198 0.0495296885230247 307 17741321 SGTC_399 oxolinic acid 75 µM 1.64736188914937 0.0473837637412592 no 199 0.0497418419535995 310 4628 A DNA gyrase inhibitor. SGTC_2318 6029776 164 µM 1.64509710381506 0.0476131877751994 no 200 0.0499748938856367 369 818325 SGTC_569 4130-2812 160 µM 1.64469718219952 0.0476537923357658 no 201 0.0500161371057918 232 743552 SGTC_2941 9056145 11.23 µM 1.64373471668502 0.047751626397691 no 202 0.0501155057610793 271 2119517 SGTC_2374 9071832 200 µM 1.64017620532314 0.048114744389646 no 203 0.0504842676223575 308 17381698 SGTC_1790 st045711 43.5 µM 1.63827844117406 0.0483092977328797 no 204 0.0506818114199857 343 585119 SGTC_3155 9099265 49.47 µM 1.63762763769309 0.0483761609618224 no 205 0.0507496970339296 319 25236499 SGTC_1393 3470-5649 58.2 µM 1.63745382308526 0.0483940311074467 no 206 0.0507678399630744 270 4108395 SGTC_1167 k781-0610 148 µM 1.63032306770493 0.0491317173138042 no 207 0.0515166173531352 403 4525169 SGTC_2127 5253358 187.912 µM 1.63032129668777 0.0491319016372425 no 208 0.0515168044068058 333 20612 SGTC_1489 4065-0444 182 µM 1.6275506473505 0.0494209415035735 no 209 0.0518101005378223 327 2877968 SGTC_200 k038-0079 37.545 µM 1.62116369275626 0.0500924134857755 no 210 0.0524912685491069 346 3436683 SGTC_924 2046-0044 21.3 µM 1.61293167762273 0.0509685666599629 no 211 0.0533796760491912 359 3623589 SGTC_592 k241-0073 46.5 µM 1.60336147113128 0.0520024334898776 no 212 0.0544274360990342 374 4230158 SGTC_2821 7996764 71.43 µM 1.60205521359143 0.0521448314181162 no 213 0.0545717002572077 413 2987135 SGTC_469 w7 172 µM 1.5954552674177 0.0528690473088079 no 214 0.0553052327565945 261 45115570 A P450 inhibitor. SGTC_2256 7954252 200 µM 1.59355563775205 0.0530789668910868 no 215 0.0555177986682772 279 2972920 SGTC_236 1509-0011 5.31 µM 1.59248564172597 0.0531974980249964 no 216 0.0556378133849663 696 3107280 SGTC_656 4090-1979 187 µM 1.59145262905402 0.0533121312385129 no 217 0.0557538740939109 408 22330961 SGTC_1804 st050076 49.1 µM 1.58582196388182 0.0539404109141118 no 218 0.0563898509111663 372 3895976 SGTC_448 monastrol 171 µM 1.57401949014966 0.055276365993527 no 219 0.0577414718214378 358 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_386 1509-0011 3.07 µM 1.57356470144328 0.0553283630305659 no 220 0.0577940595938271 497 3107280 SGTC_1991 st073000 8.92 µM 1.57126901080387 0.0555914244524923 no 221 0.0580600880855695 460 4301969 YIL048W NEO1 SGTC_913 3487-1245 167 µM 1.56956047673406 0.0557878440745116 no 222 0.0582586997382716 395 4016153 SGTC_1826 st055655 41.6 µM 1.56439759439118 0.0563847176808931 no 223 0.0588621126533859 402 676168 SGTC_1819 st053448 58.6 µM 1.56348381401096 0.0564908809150866 no 224 0.0589694199353003 371 2857616 SGTC_1078 idebenone 36.1 µM 1.55991449771188 0.0569070750354721 no 225 0.0593900439876647 458 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1280 0880-0253 10.1 µM 1.55943486355803 0.0569631855304994 no 226 0.0594467450280574 411 6836607 SGTC_460 trequinsin 123 µM 1.55846834586552 0.0570763869273431 no 227 0.0595611330160978 364 5537 A vasodilator. SGTC_1725 st036284 20.55 µM 1.55401466295259 0.0576003051732391 no 228 0.0600904595382959 447 707914 SGTC_905 2-aminofluorene 215 µM 1.55275789651324 0.0577488297184991 no 229 0.0602404924191976 424 1539 An established DNA mutagen. YPR165W RHO1 SGTC_509 pifithrin 175 µM 1.54986616590047 0.0580917176978684 no 230 0.0605868209645706 320 4817 A p53 inhibitor. SGTC_1249 0481-0015 10.2 µM 1.54740956290018 0.0583842653213395 no 231 0.0608822583678857 345 4227577 SGTC_2225 6654152 15.4 µM 1.54714756640455 0.0584155336592407 no 232 0.0609138330979979 306 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1713 st033146 12.748 µM 1.54406051030132 0.058784953862202 no 233 0.0612868371545184 404 674619 SGTC_3237 9133362 49.47 µM 1.53826867961504 0.0594829920161662 no 234 0.0619914672203958 384 43845137 SGTC_2648 atorvastatin 78.68 µM 1.53732172658111 0.0595977353448839 no 235 0.0621072717837792 358 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_960 1222-0186 7.7 µM 1.53415646640404 0.0599825326202607 no 236 0.0624955822861016 409 3126296 SGTC_1682 st012968 530 nM 1.5301025545798 0.0604782008681781 no 237 0.0629956730188508 364 24207270 SGTC_1697 st025554 27.742 µM 1.52989565239829 0.0605035843190776 no 238 0.0630212798451769 364 1269519 SGTC_823 0417-1665 178 µM 1.52841253205187 0.0606857825827564 no 239 0.0632050726311962 403 3429856 SGTC_723 4182-0001 115 µM 1.52727246424988 0.0608261290566187 no 240 0.0633466368142212 388 744821 YLR208W SEC13 SGTC_1606 st000094 49.2 µM 1.52148194694984 0.0615428846008186 no 241 0.0640694691495731 419 1242210 SGTC_1714 st033236 13.627 µM 1.52118308752892 0.0615800559364371 no 242 0.0641069491870151 438 2916566 SGTC_1630 st005209 31.3 µM 1.51317369550145 0.0625827882225576 no 243 0.0651177720016539 452 3367314 SGTC_2892 9047358 58.44 µM 1.5112976861622 0.0628194841747674 no 244 0.0653563116104187 334 6466771 SGTC_3266 9136860 49.47 µM 1.50622461077721 0.0634630477079709 no 245 0.0660047618254645 425 4871271 YPR165W RHO1 SGTC_1677 st019204 53.9 µM 1.50314169479424 0.0638566418476827 no 246 0.0664012544533992 402 3945625 SGTC_1146 3579-1023 7 µM 1.50290323986512 0.0638871641815119 no 247 0.0664319987197635 474 X1146 SGTC_2705 st078069 42.8 µM 1.50288235850291 0.0638898375450909 no 248 0.066434691502369 390 1530061 SGTC_1159 4092-0538 61.2 µM 1.50252141716201 0.0639360612804774 no 249 0.0664812505079931 460 717301 SGTC_2076 5212012 200 µM 1.49145987562859 0.065365299887404 no 250 0.0679203990686387 321 604802 SGTC_3328 9140624 29.0385 µM 1.49112914919169 0.0654084108443186 no 251 0.0679637953333152 426 4904392 SGTC_586 0957-0265 8.15 µM 1.49011304706368 0.0655410000808206 no 252 0.0680972570984121 346 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2718 lomofungin 53.02 µM 1.48995037655803 0.0655622459865672 no 253 0.0681186421239147 403 5351222 A RNA synthesis inhibitor. SGTC_2432 5630864 12.22 µM 1.48855067221863 0.065745277898887 no 254 0.0683028646322 425 5714970 SGTC_1808 st050063 61.5 µM 1.48693877588832 0.0659565474703797 no 255 0.0685154909026897 418 4011993 SGTC_1811 st050069 61.5 µM 1.48641287554267 0.066025590380782 no 256 0.0685849731102317 347 3877702 SGTC_1113 artemisinin 1.17947 µM 1.48507968642793 0.0662008692351102 no 257 0.0687613582206807 438 2240 An anti-malaria and mitochondrial poison. SGTC_2680 butyl paraben 22.24 µM 1.47822592920681 0.0671076502815296 no 258 0.0696736579303769 367 7184 An antifungal and steroid mimetic. SGTC_2531 methyl deoxycholate 70.07 µM 1.4733982320303 0.0677521195355262 no 259 0.0703218433650512 416 16667744 Haematoxylin. SGTC_549 1661-1316 519 µM 1.47322589389757 0.0677752137348521 no 260 0.0703450675847279 446 2857282 SGTC_1556 plumbagin 1.48 µM 1.46957178606916 0.0682663155739174 no 261 0.0708388831451482 362 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3269 9137823 49.47 µM 1.46929319362452 0.0683038699957919 no 262 0.0708766410740733 388 17682936 SGTC_2969 9091408 28.7 µM 1.46850172271823 0.0684106477139716 no 263 0.0709839943184894 441 4286311 SGTC_548 1436-0017 110 µM 1.46546910520354 0.0688209720374813 no 264 0.0713964877152067 537 9677137 SGTC_513 4245-1575 41.7 µM 1.46495585846927 0.0688906035661039 no 265 0.0714664806540962 606 719745 SGTC_2592 piperlongumine 83.33 µM 1.46443116470616 0.0689618442269849 no 266 0.0715380890782289 415 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1962 st076595 64.5 µM 1.46402387881193 0.0690171828894466 no 267 0.0715937120200392 454 279619 SGTC_3301 9125354 19.7965 µM 1.46278750924278 0.0691853802839661 no 268 0.071762765991947 392 41905162 SGTC_814 3342-0569 96 µM 1.46190862783735 0.0693051364287414 no 269 0.0718831251835646 482 4346283 SGTC_182 3448-4371 550.524 µM 1.45707689978514 0.0699663603971739 no 270 0.0725475770632669 463 3491403 SGTC_1068 loratadine 26.9 µM 1.45665960239172 0.0700236946623402 no 271 0.0726051831402723 424 3957 A H1 histamine antagonist. SGTC_600 1495-0418 41.6 µM 1.45440636154269 0.0703339017428734 no 272 0.0729168386395626 430 5377768 SGTC_29 0299-0004 12.984 µM 1.45146979626392 0.0707397677952755 no 273 0.0733245433813258 338 16871 A napthoquinone isolated from Swertia calycina. SGTC_463 ikarugamyin 104 µM 1.44700255355566 0.071360638577199 no 274 0.0739481041909605 338 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1309 pyrazolanthrone 13.4 µM 1.44683361586912 0.0713841998613135 no 275 0.0739717646538929 467 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2572 astragaloside iv 100 µM 1.44532717819655 0.0715945627482743 no 276 0.0741830036758888 453 45006101 An anti-inflammatory agent. SGTC_2699 st077704 54.6 µM 1.44362207620878 0.0718332411354355 no 277 0.0744226557856075 457 645852 SGTC_760 0568-0725 82.9 µM 1.44030020795176 0.0722999846722289 no 278 0.0748912413065437 459 3916171 SGTC_307 1501-1223 22.3 µM 1.43902247770337 0.0724801314649272 no 279 0.0750720771519245 451 2830329 SGTC_3241 9133421 49.47 µM 1.43895644494408 0.0724894507392937 no 280 0.0750814317416623 358 17018221 SGTC_1992 st073643 23.3 µM 1.4365593337392 0.0728283794736894 no 281 0.0754216228267924 436 3161292 SGTC_2271 7849410 118.62 µM 1.43528438177443 0.0730091391182212 no 282 0.0756030382450759 437 972430 SGTC_2147 5545932 89.7195 µM 1.43363100787794 0.0732440616486771 no 283 0.075838794962053 428 797404 SGTC_3214 9129694 49.47 µM 1.43194508041183 0.0734842046643219 no 284 0.0760797696546771 429 17158655 SGTC_1205 4161-2785 76 µM 1.43092090611792 0.0736303814584299 no 285 0.0762264423153384 419 3498106 SGTC_882 0843-0131 351 µM 1.42860966902356 0.0739610729949223 no 286 0.0765582267647461 482 5425421 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.42462330080512 0.0745341070760318 no 287 0.0771330604346283 474 94937 An inhibitor of serotonin biosynthesis. SGTC_2853 9015042 58.44 µM 1.42321785345306 0.0747369439209704 no 288 0.0773365058169885 423 6457456 SGTC_2788 5282734 71.43 µM 1.42314148453199 0.074747977683101 no 289 0.077347572256966 523 743706 SGTC_806 3966-4455 5.86 µM 1.4156976231999 0.075829441026527 no 290 0.078432027287876 409 714982 SGTC_2164 5685496 200 µM 1.41543524153834 0.0758677767941714 no 291 0.0784704614796712 482 759046 SGTC_989 1501-0895 10.3 µM 1.41327919767892 0.0761833487847449 no 292 0.0787868239970719 441 2830112 SGTC_1974 st069448 26.9 µM 1.41113765307814 0.0764977866122993 no 293 0.0791020147316494 442 6323587 YNR016C ACC1 SGTC_3085 9117376 49.47 µM 1.40523391237518 0.0773697306475084 no 294 0.0799758664839238 462 16480349 SGTC_2206 7254556 146.969 µM 1.40137090387827 0.0779443444899405 no 295 0.0805515941847887 408 4398905 SGTC_1896 st058441 89 µM 1.39953756660528 0.0782181798077814 no 296 0.0808259206292474 442 688759 SGTC_734 2023-0417 80 µM 1.39742544788762 0.0785345589602191 no 297 0.0811428355140599 496 3935732 SGTC_1967 st070177 51.4 µM 1.39281895041433 0.0792279405359687 no 298 0.0818372731827689 441 5729214 SGTC_2808 7946468 45.46 µM 1.392698403683 0.079246147565587 no 299 0.0818555057716512 537 2970879 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.39252217224349 0.0792727707528032 no 300 0.0818821661335511 465 75037 A free radical scavenger. SGTC_2913 7966556 36.57 µM 1.38924690684915 0.0797687964389341 no 301 0.0823788412705925 442 2976516 SGTC_3028 9087778 49.47 µM 1.38741610122468 0.0800470855527624 no 302 0.0826574590272664 453 17217395 SGTC_482 fipronil 114 µM 1.38646421581697 0.0801920653149599 no 303 0.0828025998783195 392 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2783 7738165 71.43 µM 1.38592728386498 0.0802739318502935 no 304 0.082884554321104 394 17201110 SGTC_1390 3413-2614 145 µM 1.38578055132723 0.0802963152876837 no 305 0.082906961410184 513 3421432 SGTC_801 0866-0028 10.1 µM 1.38550689468286 0.0803380730693634 no 306 0.0829487628759038 520 6849771 SGTC_3239 9133757 49.47 µM 1.37995563278364 0.081188697239302 no 307 0.0838001528810607 452 17036923 SGTC_2181 6316240 54.2555 µM 1.37809641868193 0.0814750999561265 no 308 0.0840867605743408 453 12779990 SGTC_1299 1079-1439 3.74 µM 1.37795405505735 0.0814970617325507 no 309 0.0841087369756916 482 323161 SGTC_216 k038-0035 28.382 µM 1.37531281169522 0.0819053242540642 no 310 0.084517243129182 447 4444231 YPR107C YTH1 SGTC_286 k060-0067 22.9 µM 1.37479533207733 0.0819854924172666 no 311 0.0845974528540388 466 5985051 SGTC_1370 2001-0092 44.6 µM 1.37265653821161 0.0823174625408574 no 312 0.0849295732356503 576 790957 SGTC_1386 3228-0095 33.8 µM 1.37234113636783 0.0823665027522802 no 313 0.0849786326676779 473 870181 SGTC_1245 0418-0076 17.2 µM 1.37070583855059 0.0826211195794647 no 314 0.0852333370135637 519 6790114 SGTC_1490 4089-0339 670 nM 1.36912179661378 0.0828683202456886 no 315 0.0854806030115094 448 742542 SGTC_3257 9139206 32.98 µM 1.36800973331637 0.0830421975564922 no 316 0.0856545147256718 413 4910041 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.3656970181884 0.0834046819769128 no 317 0.086017040320517 492 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.36458659013534 0.0835791474319729 no 318 0.0861915109284927 545 23665772 A membrane-active detergent. SGTC_1122 capsaicin 818.572 nM 1.36275154992374 0.083868061496743 no 319 0.086480412658309 504 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_640 3381-0960 37.1 µM 1.36215226976436 0.0839625761962318 no 320 0.0865749176898481 521 1745025 SGTC_2 0422-0095 29 µM 1.36086218105404 0.0841663122588419 no 321 0.0867786234959978 395 6790840 SGTC_51 1013-0126 23.419 µM 1.36059111490441 0.0842091672672724 no 322 0.086821470505377 472 1627850 SGTC_316 k060-0003 58.6 µM 1.36018564224257 0.0842733022427192 no 323 0.0868855924500044 481 6152314 SGTC_3081 9117243 49.47 µM 1.3597459413807 0.0843428926318346 no 324 0.0869551672638973 470 45595589 SGTC_888 0916-0002 6.97 µM 1.35331437867469 0.0853657344912847 no 325 0.0879776087895241 516 2802138 YIL048W NEO1 SGTC_1291 0993-0025 5.79 µM 1.35305327387995 0.0854074546313968 no 326 0.0880193058266636 504 4353356 SGTC_2517 totarol 10 µM 1.3515635483908 0.0856457798105856 no 327 0.0882574889183008 460 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_996 3970-0799 1.8 µM 1.3507057728458 0.085783231807221 no 328 0.0883948511576512 676 6615648 YGL040C HEM2 SGTC_1211 1056-0033 32.3 µM 1.34727046763989 0.0863353684298215 no 329 0.0889465699311307 528 6741922 SGTC_470 aa-861 153 µM 1.3450090056562 0.0867002879327871 no 330 0.089311163171825 561 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2333 9017922 200 µM 1.3447570605029 0.0867410141749866 no 331 0.0893518505408458 508 3163164 SGTC_1731 st035964 63 µM 1.33784404326742 0.0878640694125513 no 332 0.0904736405846746 517 6739575 SGTC_1647 st011722 22.4 µM 1.33612406281525 0.0881451665126566 no 333 0.0907543630713812 483 2854783 SGTC_3032 9089427 49.47 µM 1.3361060124141 0.088148120047526 no 334 0.0907573125478283 475 17173707 SGTC_1878 temozolomide 1 mM 1.33578725185607 0.0882002900703925 no 335 0.0908094104658785 483 5394 DNA alkylating agent. SGTC_1906 st060206 94.7 µM 1.33234875116035 0.088764517025285 no 336 0.0913728071363339 549 5133468 SGTC_3135 9127742 49.47 µM 1.33203247035236 0.0888165505330293 no 337 0.0914247594373894 490 3643468 SGTC_738 1315-0003 72.4 µM 1.32878126508134 0.0893527457198994 no 338 0.0919600724511624 553 6251474 SGTC_1114 scopoletin 1.73284 µM 1.32635197054727 0.0897549589575396 no 339 0.0923615699367783 497 5280460 A coumarin with genotoxic properties. SGTC_2770 toltrazuril 17.5 µM 1.32325156311788 0.0902702399904973 no 340 0.0928758668337183 548 68591 Kills coccidiodes. SGTC_2323 6148992 148.28 µM 1.32255063968456 0.09038703586412 no 341 0.092992429201582 467 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2591 skatole 100 µM 1.318932826204 0.0909916621028864 no 342 0.0935957853329071 516 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_947 3447-0010 211 µM 1.31528260798881 0.0916047393845377 no 343 0.0942074705109999 511 748350 SGTC_193 1273-0060 1.558 µM 1.31331835970606 0.0919359114390868 no 344 0.0945378472381015 439 2847393 YHR072W ERG7 SGTC_393 acivicin 6.25 µM 1.30960659341302 0.0925641342143368 no 345 0.0951644783933764 493 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1313 1220-0047 237 µM 1.30798424140734 0.0928397152471723 no 346 0.0954393271727767 596 3528706 SGTC_1525 8-methoxypsoralen 92.5 µM 1.30700909767379 0.0930056498081698 no 347 0.0956048108567399 598 4114 Related to psoralen; DNA damaging agent. SGTC_2107 5363541 170.161 µM 1.30690746421158 0.0930229567930122 no 348 0.095622070384526 535 244052 SGTC_2075 5212009 200 µM 1.30648895499626 0.0930942490814415 no 349 0.0956931663276209 471 780898 SGTC_2650 prasterone 100 µM 1.30171043994275 0.0939111251486459 no 350 0.0965076946840222 451 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.30070710972716 0.094083312087256 no 351 0.0966793638755286 431 1241132 A phosphatase inhibitor. SGTC_3211 9128781 49.47 µM 1.30008527887686 0.0941901447043078 no 352 0.0967858712746192 546 17194361 SGTC_3276 9139060 49.47 µM 1.297942825875 0.0945589105776177 no 353 0.0971534911872284 485 4870619 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.29449521059499 0.095154557838819 no 354 0.0977472112775432 544 6710655 SGTC_3061 glucosamine 200 µM 1.29367151984881 0.0952972756225453 no 355 0.097889453409376 523 91431 and experimental redox chemotherapeutic SGTC_2281 7943571 200 µM 1.29203856798769 0.0955806768280599 no 356 0.0981718942381106 567 1244024 SGTC_1624 st003710 6.25 µM 1.28801817491477 0.0962810642894996 no 357 0.098869818277462 611 24207033 SGTC_3170 9103054 49.47 µM 1.2873234891266 0.0964024658357199 no 358 0.0989907798646797 507 16432970 SGTC_758 0868-0029 16 µM 1.28177353123899 0.0973764039126867 no 359 0.0999610509312065 554 762687 SGTC_597 k018-0003 82.8 µM 1.28019772598706 0.0976542463773921 no 360 0.100237802747477 608 6786234 SGTC_63 0099-0242 26.702 µM 1.28013871342051 0.0976646626216154 no 361 0.100248177721322 628 3898502 YLR359W ADE13 SGTC_1895 st058434 18.3 µM 1.27985862664552 0.0977141115439003 no 362 0.100297430344912 573 5393175 SGTC_320 4092-0846 5.34 µM 1.27618268091656 0.0983647966629829 no 363 0.100945474702701 561 1359356 SGTC_2589 lobaric acid 100 µM 1.27492632720696 0.0985879118505945 no 364 0.101167659795296 556 73157 A novel microtubule depolymerizer. SGTC_1320 1313-0481 95.3 µM 1.27489568667856 0.0985933579097211 no 365 0.101173082995144 566 6813365 YLR208W SEC13 SGTC_1185 1319-0113 81.3 µM 1.27392349607267 0.0987662698014875 no 366 0.101345265238437 496 4672763 SGTC_585 0kpi-0023 191 µM 1.27295853447579 0.0989381153061243 no 367 0.101516378174923 522 64601 SGTC_2516 gossypol 71.55 µM 1.27210376328836 0.0990905201289345 no 368 0.10166812712927 605 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_565 1418-0001 44.5 µM 1.26706134784029 0.0999930728473419 no 369 0.102566677426816 603 2862145 SGTC_1208 2323-2347 50.3 µM 1.26671521693597 0.100055247026376 no 370 0.102628568474854 575 5412760 SGTC_141 0443-0274 32.331 µM 1.26583001714194 0.100214380495287 no 371 0.102786972943742 688 1627241 SGTC_844 0330-0132 15.3 µM 1.2609662992626 0.101092034212529 no 372 0.103660494687134 575 2828079 SGTC_1254 0550-0035 264 µM 1.26071571662299 0.101137402905634 no 373 0.103705644683954 617 15121435 SGTC_229 benomyl 22.8748 µM 1.25876662356939 0.101490798364937 no 374 0.104057319557664 602 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2746 daunorubicin 9.88 µM 1.25755295702796 0.101711305491606 no 375 0.104276737808574 407 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2372 9071633 200 µM 1.25622861876387 0.101952317939918 no 376 0.104516546736627 630 21321366 SGTC_2100 5377183 190 µM 1.25414711818542 0.102331963673126 no 377 0.104894268414558 631 2844202 SGTC_2973 9094665 17.96 µM 1.25359551869818 0.102432742238066 no 378 0.104994530443533 635 25237061 YIL048W NEO1 SGTC_1364 1653-0028 37.6 µM 1.25105622310825 0.1028976085609 no 379 0.105456982814876 595 5718652 SGTC_552 k242-0005 476 µM 1.24897252415397 0.103280212687263 no 380 0.105837561723856 567 4088318 SGTC_1755 st041960 45.185 µM 1.24894829465623 0.103284667720309 no 381 0.105841992971679 568 2257073 SGTC_154 3389-1638 511.116 µM 1.24747154876337 0.103556457718045 no 382 0.106112323053655 510 5238686 SGTC_3195 9113082 49.47 µM 1.24710996280154 0.103623085399562 no 383 0.106178590194458 543 17018038 SGTC_1326 1431-2094 10.8 µM 1.24114585718706 0.104726553118287 no 384 0.107275935885833 612 616278 SGTC_1424 4048-1941 275 µM 1.23825220515915 0.105264986838586 no 385 0.107811279853735 645 X1424 SGTC_495 decylubiquinone 155 µM 1.2381655349993 0.105281144747961 no 386 0.107827344010649 575 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3124 9127567 49.47 µM 1.23809470483159 0.105294350941578 no 387 0.107840473533898 552 17592030 SGTC_800 3448-7362 155 µM 1.23663898156135 0.105566034156447 no 388 0.108110570576214 851 15991913 SGTC_558 k064-0027 21.3 µM 1.23636642060968 0.105616958794995 no 389 0.108161196018833 594 5088526 SGTC_3286 9117135 37.221 µM 1.22952414322406 0.106901178699206 no 390 0.109437675744328 574 3438150 SGTC_2666 tannic acid 100 µM 1.22680170529451 0.107415270665018 no 391 0.109948564871817 641 16134267 A thiamine antagonist. SGTC_3255 9139072 49.47 µM 1.2247428106822 0.107805244072915 no 392 0.110336069294895 611 17646060 SGTC_1199 1638-0010 4.46 µM 1.22367301545138 0.108008275182375 no 393 0.110537801584503 635 3111136 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.22145275970162 0.108430524801493 no 394 0.110957320758723 583 688662 SGTC_732 3970-1727 52.7 µM 1.21924750033628 0.108851096826495 no 395 0.11137513408837 578 1275699 SGTC_2878 9043973 25.97 µM 1.21805092908171 0.10907978897275 no 396 0.11160230985031 572 6465167 SGTC_2799 7812892 81.82 µM 1.21704721796945 0.109271887277341 no 397 0.111793125568462 642 20205235 SGTC_2667 digitoxin 100 µM 1.21660329201905 0.109356926871359 no 398 0.111877594803891 505 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1330 1469-0054 61.8 µM 1.21432843629656 0.10979345009338 no 399 0.112311165492144 601 7102664 SGTC_1660 st012960 28.1 µM 1.2142403828956 0.109810371812011 no 400 0.112327971923176 609 24207266 SGTC_1736 st036774 51 µM 1.2133420352323 0.109983119326657 no 401 0.112499538960667 633 1272247 SGTC_531 3788-1495 174 µM 1.21313214667522 0.110023507874557 no 402 0.11253965058025 604 2896655 SGTC_1251 0490-5699 265 µM 1.21213840410679 0.110214876768607 no 403 0.112729702542107 672 3883818 SGTC_2514 salinomycin 42.74 µM 1.20916213447508 0.110789456611988 no 404 0.11330028094903 680 23682228 A polyether potassium ionophore. SGTC_570 0987-0065 62.6 µM 1.20838562908529 0.110939716243539 no 405 0.113449482474708 509 3104428 SGTC_1897 st060201 15 µM 1.2029841015381 0.111988993075517 no 406 0.11449123645676 580 611878 SGTC_375 3970-0961 9.27 µM 1.19885474056586 0.112795916513272 no 407 0.115292216473412 620 2898222 SGTC_500 h-89 112 µM 1.1962581319295 0.113305444019775 no 408 0.115797920910253 670 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1727 st034309 9.9045 µM 1.19499293257403 0.113554305665946 no 409 0.11604489570127 708 870305 SGTC_479 n-linoleoylglycine 10 µM 1.19478772813206 0.113594705585267 no 410 0.116084988100736 580 6433346 An anti-infammatory. SGTC_1412 3909-8563 178 µM 1.19380339384705 0.113788640286548 no 411 0.116277441896018 693 23767530 SGTC_130 0136-0219 337.655 µM 1.19314930233392 0.113917640599964 no 412 0.116405452851202 654 234244 SGTC_1450 4112-4260 37.6 µM 1.19213823750823 0.11411724837594 no 413 0.116603522997296 657 1633175 SGTC_1572 epiandrosterone 68.9 µM 1.1866850443771 0.115198131556651 no 414 0.117675938182769 675 441302 A steroid. SGTC_111 0083-0039 52.457 µM 1.18568860918591 0.115396419920833 no 415 0.117872647283368 483 759313 SGTC_706 4262-0057 46.9 µM 1.18559763474848 0.115414535705939 no 416 0.117890618388909 614 883298 SGTC_1124 fisetin 1.16336 µM 1.18460840719581 0.115611651560857 no 417 0.118086155714878 573 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_172 1112-0046 2.638 µM 1.18438101076319 0.115656996906441 no 418 0.118131136819457 560 2802135 YIL048W NEO1 SGTC_847 0342-0274 5.54 µM 1.1842634464675 0.115680445471572 no 419 0.118154396869016 648 18097 SGTC_2441 5730946 39.09 µM 1.18293912668641 0.115944818467351 no 420 0.118416636767304 641 1774275 SGTC_963 1269-2853 151 µM 1.18237679124627 0.116057206730526 no 421 0.118528113967619 592 3668223 SGTC_1856 st057054 55.7 µM 1.18074838204537 0.116383096443093 no 422 0.118851347574964 669 1266018 SGTC_2610 ononetin 44.17 µM 1.17791782608278 0.116951112919851 no 423 0.119414683847441 648 259632 SGTC_284 0988-0104 32.6 µM 1.17783512011293 0.116967739274819 no 424 0.119431172241783 656 4666532 SGTC_428 3448-4153 16.5 µM 1.17519514760716 0.117499332452239 no 425 0.119958325558538 558 3834874 SGTC_1140 3229-1848 2.98 µM 1.17207713827329 0.118129385032057 no 426 0.120583043818993 645 2849525 SGTC_988 1497-1057 103 µM 1.17052418741377 0.118444077830801 no 427 0.120895043156097 658 3533044 SGTC_1793 st048256 72.231 µM 1.17036728158899 0.118475906441928 no 428 0.120926598269274 635 672022 SGTC_311 1315-0136 58 µM 1.16872790732136 0.118808817843217 no 429 0.121256637201524 667 6759207 SGTC_2959 9079155 11 µM 1.16729658031728 0.119100020471079 no 430 0.12154530959683 570 16189457 SGTC_3017 9080681 49.47 µM 1.16448673426733 0.119673146699643 no 431 0.122113408131981 635 16451914 SGTC_1739 st037196 92.5 µM 1.16189126609966 0.12020427178665 no 432 0.122639817634406 706 612214 SGTC_1531 st059297 52.4 µM 1.16042804033518 0.120504430863972 no 433 0.122937287918015 677 7566702 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.16017501296598 0.120556389159927 no 434 0.1229887790353 669 5379071 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.15890821656459 0.120816758613844 no 435 0.123246799676299 727 91467 include heat shock SGTC_2843 9000894 45.46 µM 1.15751999091218 0.121102540095993 no 436 0.123529988314255 507 2242070 SGTC_1688 st021091 57.6 µM 1.15687198563194 0.121236101757643 no 437 0.123662332902741 648 3656366 SGTC_36 0335-0881 14.2 µM 1.15439600102947 0.121747385900493 no 438 0.1241689269587 707 23828853 SGTC_1023 4482-3888 16 µM 1.15367018756107 0.121897551167928 no 439 0.124317705415738 653 3303168 SGTC_379 3970-0972 5.9 µM 1.14596367867046 0.123499996430595 no 440 0.125905090491937 651 2898042 YBL034C STU1 SGTC_3016 9080866 49.47 µM 1.14410618925597 0.12388842845649 no 441 0.126289800601811 693 17066299 SGTC_212 3807-4682 38.772 µM 1.14292844741953 0.124135156448892 no 442 0.126534150142007 828 3125501 YBL034C STU1 SGTC_830 4076-0286 57.8 µM 1.14117984029973 0.124502110146457 no 443 0.126897545902717 810 6866659 SGTC_1941 st076221 61.8 µM 1.14070411092281 0.124602075368225 no 444 0.126996537634614 721 2828568 SGTC_993 3909-8757 62.7 µM 1.1402052467094 0.12470696217474 no 445 0.127100401076133 613 4288324 YLR208W SEC13 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.13769818436479 0.125235009300582 no 446 0.127623265919787 709 5106787 A p450 inhibitor. SGTC_3288 9119690 36.221 µM 1.13466636662642 0.125875665399523 no 447 0.128257567251995 611 17595618 YKL019W RAM2 SGTC_3105 9121040 49.47 µM 1.13330982338825 0.126163056641187 no 448 0.12854208396451 432 41448907 SGTC_1454 4239-0054 42.6 µM 1.13327702700858 0.126170010394805 no 449 0.12854896798329 724 1340767 SGTC_1641 st009299 47.1 µM 1.13278476636499 0.126274415576443 no 450 0.128652325116414 601 4046054 SGTC_827 3253-0474 693 µM 1.13236590832626 0.126363299957492 no 451 0.128740315723777 726 5402065 SGTC_1057 3448-5381 134 µM 1.13091185824104 0.126672197093807 no 452 0.129046095853829 682 5497911 SGTC_46 0329-0187a 2.197 µM 1.12853649960825 0.127177946682547 no 453 0.129546705616062 775 46494817 SGTC_1052 3253-3998 198 µM 1.12850447561906 0.12718477465611 no 454 0.129553463889884 713 5450317 SGTC_1650 st011916 45.8 µM 1.12490725202908 0.127953378213889 no 455 0.130314169291012 675 242528 SGTC_2652 actinonin 100 µM 1.12382760169524 0.128184690884868 no 456 0.13054308478809 652 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1003 4049-0218 100 µM 1.12199537736269 0.128577905145806 no 457 0.130932202689688 705 295161 SGTC_620 0109-0052 432 µM 1.12006599207681 0.128992875177911 no 458 0.131342820686857 710 493037 SGTC_1232 0279-0259 161 µM 1.11543384616693 0.129992940593495 no 459 0.132332276163331 699 1560000 SGTC_496 calpeptin 138 µM 1.11295559365939 0.130530185515166 no 460 0.132863750838274 591 73364 A calpain inhibitor. SGTC_3199 9111318 49.47 µM 1.11294538712456 0.13053240129643 no 461 0.132865942719656 703 8548020 SGTC_1009 4106-0057 9.87 µM 1.11286816825631 0.130549165920916 no 462 0.132882526490441 728 2928005 SGTC_3013 9080133 71.4286 µM 1.11219389167268 0.130695618195063 no 463 0.133027396841698 754 17050193 SGTC_1775 st081588 35.1725 µM 1.1090379431612 0.131382597058687 no 464 0.133706906925163 728 1426443 YGL099W LSG1 SGTC_2223 6903751 107.57 µM 1.1065198770211 0.131932508544938 no 465 0.134250782746486 651 5598863 SGTC_2217 6934799 96.0675 µM 1.10629637126126 0.131981395770163 no 466 0.134299130955713 690 675606 SGTC_2344 7990960 76.95 µM 1.10456222462294 0.13236112871975 no 467 0.134674663542003 665 140813 SGTC_2978 9011784 42.97 µM 1.10449502235209 0.13237585940704 no 468 0.134689230805225 816 2994934 SGTC_1255 0566-0045 221 µM 1.10115487963046 0.133109440139277 no 469 0.135414627700723 705 2788469 SGTC_2846 9008642 19.48 µM 1.09999814494567 0.133364139685078 no 470 0.13566646507442 649 2992898 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.0992175091561 0.133536215981333 no 471 0.135836601647901 795 551469 SGTC_273 hydroxyurea 18.1 mM 1.09891192435253 0.133603617899653 no 472 0.135903242459145 782 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2785 7756463 72.73 µM 1.09609218472654 0.134226663241112 no 473 0.136519217215746 685 2201551 SGTC_2101 5377231 179.231 µM 1.09263183710823 0.134993979679607 no 474 0.137277739206392 710 2844213 SGTC_719 2810-4230 27.3 µM 1.09078066244518 0.135405702179347 no 475 0.137684703681081 679 721079 SGTC_3072 9116419 49.47 µM 1.0899691017984 0.13558647365697 no 476 0.137863377499227 626 17170162 SGTC_57 miconazole 162.5 nM 1.08895847409797 0.135811817483747 no 477 0.138086099131178 677 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.08778178298441 0.136074512152219 no 478 0.138345726744145 764 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_423 5-fluorouracil 457 µM 1.0871346349474 0.136219135206489 no 479 0.138488656581995 681 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2151 5563267 85.4165 µM 1.08615434526152 0.136438408219722 no 480 0.138705356054846 745 5310824 SGTC_2051 5263410 176 µM 1.08578823969668 0.136520361280046 no 481 0.138786345299525 746 227584 SGTC_2876 9059903 25.97 µM 1.08569161768517 0.136541995818381 no 482 0.138807725225605 768 6916095 SGTC_1548 st061468 90.8 µM 1.08303665133826 0.137137384180713 no 483 0.13939607756704 750 390799 SGTC_486 niguldipine 82 µM 1.08222088539597 0.137320679095239 no 484 0.139577195145463 657 1236 A calcium channel blocker. SGTC_158 k038-0087 26.446 µM 1.08216225276108 0.137333859737056 no 485 0.139590219012781 815 X158 SGTC_1938 st074717 56.4 µM 1.08206353249712 0.137356054047208 no 486 0.139612149275552 656 17250979 SGTC_985 1493-0307 8.71 µM 1.08159096639701 0.137462330379585 no 487 0.139717160159466 670 3278274 SGTC_2158 5657123 3.6195 µM 1.08053282825597 0.137700500723925 no 488 0.139952488147241 726 2858827 SGTC_131 0141-0277 33.849 µM 1.08039169397186 0.137732289116617 no 489 0.139983896501753 723 1547771 SGTC_2433 5607874 27.82 µM 1.07950339909482 0.137932479233626 no 490 0.140181689669475 706 2252428 SGTC_556 4058-0063 51.5 µM 1.0790480973003 0.138035164989722 no 491 0.140283143505915 773 6615692 SGTC_2794 7785382 27.27 µM 1.07831621979573 0.138200337041274 no 492 0.140446330545869 816 2205081 SGTC_1749 st037932 54.2 µM 1.07779115176134 0.138318918768915 no 493 0.140563484560963 674 594497 SGTC_1389 3405-0187 19 µM 1.07565446193717 0.138802185527736 no 494 0.14104091028451 659 799890 SGTC_1331 1472-0049 76.2 µM 1.074639206451 0.139032213909189 no 495 0.141268145730344 700 24051409 SGTC_2551 apiole 73.87 µM 1.07408958150115 0.139156851700183 no 496 0.141391266800254 583 10659 A possible DNA adduct former. SGTC_3094 9117742 49.47 µM 1.07352587292683 0.139284762187704 no 497 0.141517618256224 769 17149698 SGTC_173 1273-0061 2.693 µM 1.0718189927174 0.139672556225402 no 498 0.141900670334774 731 2847414 YPL266W DIM1 SGTC_112 phenothiazine 287.218 µM 1.07047053463636 0.139979437273652 no 499 0.14220378251903 762 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2278 7948257 134.34 µM 1.07009489980753 0.140065005492003 no 500 0.142288297295777 740 1247028 SGTC_407 eburnamonine 100 µM 1.0681778371313 0.140502258698522 no 501 0.1427201500308 670 3195 SGTC_225 nsc-122657 1.016 µM 1.06768146417266 0.140615624786152 no 502 0.14283211120763 592 275685 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.06692964095907 0.140787451086579 no 503 0.143001804408663 817 688761 SGTC_646 4092-0839 27.3 µM 1.06630685510238 0.140929894238305 no 504 0.143142475848315 753 877796 SGTC_2381 9035592 200 µM 1.06591821447138 0.141018833376804 no 505 0.143230307206193 664 4749657 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.06590800109919 0.141021171186892 no 506 0.143232615881618 798 1377 SGTC_1298 1079-1278 263 µM 1.06384075672627 0.141494898327769 no 507 0.143700422287552 766 2840950 SGTC_2716 st080858 38.6235 µM 1.06133211049532 0.142071223330838 no 508 0.144269498902003 768 5296050 SGTC_1648 st011736 69.8 µM 1.06060559476655 0.142238426059523 no 509 0.14443458945828 719 2855514 SGTC_817 1391-0715 46 µM 1.05689485647452 0.143094504005251 no 510 0.145279788077793 704 1353946 SGTC_3313 9133968 57.047 µM 1.05353495270404 0.143872640307326 no 511 0.14604794181022 793 1494643 SGTC_1834 st055981 52.8 µM 1.05289237594629 0.14402178230623 no 512 0.146195160362704 767 471719 YDL150W RPC53 SGTC_1655 st012546 55.1 µM 1.04998105431421 0.144698805775267 no 513 0.146863411694021 720 720985 YLR208W SEC13 SGTC_1336 1486-0901 104 µM 1.04962909927935 0.14478079738828 no 514 0.146944336430484 744 5006114 SGTC_2723 salbutamol 83.58 µM 1.04940560391187 0.144832879214848 no 515 0.146995740061797 661 9884233 β2-adrenoceptor agonist SGTC_2379 9035213 200 µM 1.04791031816395 0.145181654879411 no 516 0.147339963962487 821 646551 SGTC_2458 5808907 16.39 µM 1.04421696741506 0.146045549961215 no 517 0.148192509253477 829 2731747 SGTC_3064 1327-0027 10 µM 1.04357700194494 0.146195591739982 no 518 0.148340568903458 592 16000455 YPR107C YTH1 SGTC_1435 4092-0789 56.7 µM 1.04296853218624 0.146338345237508 no 519 0.148481433574264 765 2248285 SGTC_1410 3909-8106 77.9 µM 1.04243135814263 0.146464449762035 no 520 0.148605867147546 748 1039210 SGTC_659 k018-0002 107 µM 1.04052913207276 0.146911594067111 no 521 0.149047068355015 785 6797879 YHR007C ERG11 SGTC_852 0418-0143 439 µM 1.03836335709713 0.147421802710566 no 522 0.149550461148856 848 5369229 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.03526513897608 0.148153736113865 no 523 0.150272552769956 779 16623 A steroid. SGTC_961 1252-1571 372 µM 1.03504101719466 0.148206777542503 no 524 0.150324878074607 783 6813498 SGTC_1925 st057770 10.1 µM 1.0343047142909 0.148381122936479 no 525 0.150496866827911 694 5989122 SGTC_1716 st033144 30.6155 µM 1.03422178829259 0.148400767150162 no 526 0.150516245243611 796 674617 SGTC_2546 rhodinyl acetate 100 µM 1.03330142076064 0.148618908395948 no 527 0.150731431298016 802 6708682 SGTC_1842 st055362 61.2 µM 1.03090461727666 0.149187993239014 no 528 0.151292775578724 804 676032 SGTC_1547 harmine 94.2 µM 1.02914328576965 0.149607121293689 no 529 0.151706174130648 844 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_322 k048-0136 19.3 µM 1.0282355416236 0.149823435444014 no 530 0.151919521797816 724 6823282 SGTC_294 k038-0071 157 µM 1.02674699899932 0.150178604374181 no 531 0.152269806105509 768 24152826 SGTC_2731 amoxapine 43.43 µM 1.02652781269819 0.150230949981048 no 532 0.152321430346233 689 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1588 farnesol 29.9 µM 1.02592351262938 0.150375330611789 no 533 0.152463819352025 777 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1786 berberine 21.6 µM 1.02433627069393 0.150754997965085 no 534 0.152838235914855 740 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3121 9125696 49.47 µM 1.02378310999994 0.150887463526154 no 535 0.152968864868305 778 1235365 SGTC_2404 5161160 200 µM 1.02347798476447 0.150960565105277 no 536 0.153040951889624 811 2831543 SGTC_1795 st049545 62.3 µM 1.02263186153654 0.151163401698689 no 537 0.153240969574853 779 5291882 SGTC_1081 sertraline 6 µM 1.02175586024804 0.15137359174858 no 538 0.153448232650962 804 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_299 1273-0059 1.44 µM 1.01983698393355 0.151834690847014 no 539 0.153902889904605 737 2848077 SGTC_257 daunorubicin 18.5 µM 1.01927951543478 0.151968823288121 no 540 0.154035143062987 777 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2340 7987427 183.45 µM 1.01925809753331 0.151973978216947 no 541 0.154040225719733 752 2239331 SGTC_1008 4106-0037 6 µM 1.01842915599748 0.152173579751078 no 542 0.154237026102368 775 2905394 SGTC_2671 danthron 100 µM 1.01807547332091 0.152258796257823 no 543 0.154321045079881 762 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1527 coumarin 137 µM 1.01755482272655 0.15238429974566 no 544 0.154444783126274 731 323 A hepatotoxic, DNA x-linker. SGTC_2704 st078022 71.1 µM 1.01721804126123 0.152465517907508 no 545 0.154524857681428 806 54697681 SGTC_2194 5927483 104.545 µM 1.0169138517364 0.152538900889315 no 546 0.154597206624269 827 760979 SGTC_3054 9094397 49.47 µM 1.01640208196167 0.152662413609071 no 547 0.154718977306434 794 2598354 SGTC_1355 1499-0035 1.68 µM 1.01563258617588 0.152848251872138 no 548 0.154902190658627 762 1548538 SGTC_3078 9116413 49.47 µM 1.01513867357893 0.152967614008587 no 549 0.155019864418742 723 17177322 SGTC_82 0054-0107 293.755 µM 1.01238181548273 0.153634989167032 no 550 0.155677764783293 795 3104697 SGTC_2373 9071805 200 µM 1.01118584017057 0.153925107372934 no 551 0.155963745819994 804 10149009 SGTC_1340 1486-1359 257 µM 1.01090551982753 0.153993159545205 no 552 0.156030825945962 788 4309068 SGTC_2399 5884133 200 µM 1.00501642616238 0.15542743149943 no 553 0.157444470185646 756 722445 SGTC_3198 9112019 49.47 µM 1.00438395780592 0.155581989833707 no 554 0.157596789705542 780 45595555 SGTC_2023 5144124 124 µM 1.00399202097089 0.15567781956502 no 555 0.157691229770452 796 2830192 SGTC_3333 9141820 12.094 µM 1.00082674873403 0.156453164501858 no 556 0.158455287636404 739 1939433 SGTC_1552 6-methylflavone 10.6 µM 0.998752455048058 0.156962647166843 no 557 0.158957311585095 766 689013 SGTC_2280 7785178 200 µM 0.998121816116226 0.157117759190055 no 558 0.159110146231246 778 2954328 SGTC_457 grayanotoxin iii 135 µM 0.997732415032774 0.157213586648033 no 559 0.159204565208017 840 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3309 9129340 25.759 µM 0.996149830619256 0.157603439205437 no 560 0.159588675664931 861 17158987 SGTC_2408 sulbentine 18.36 µM 0.995929653310658 0.157657727793666 no 561 0.159642163115251 791 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1072 oxiconazole 14.9 nM 0.995648642250717 0.157727033857232 no 562 0.159710445886328 824 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1444 4112-3581 28 µM 0.995214384409317 0.15783417469484 no 563 0.159816003613489 839 2877249 SGTC_692 k241-0027 77.8 µM 0.994065959916774 0.158117746235067 no 564 0.160095378121889 785 3600480 SGTC_2566 crystal violet carbinol 226 nM 0.993361155006816 0.158291943726119 no 565 0.160266992365863 671 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2686 alizarin 95.37 µM 0.993221716783415 0.158326421778759 no 566 0.160300958677141 738 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2735 sertaconazole 140 nM 0.991519426421977 0.158747734120601 no 567 0.160716005642759 773 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_127 0180-0333 59.125 µM 0.989509460946212 0.159246140599988 no 568 0.161206971631836 870 771601 SGTC_3083 9117465 49.47 µM 0.989043847210176 0.159361743799394 no 569 0.161320844623059 799 16420915 SGTC_3299 9121982 43.1275 µM 0.985910987819005 0.160141002627565 no 570 0.162088397246288 812 17594604 YPL160W CDC60 SGTC_536 3852-0578 10.6 µM 0.985549453751588 0.16023108967685 no 571 0.162177126151182 843 2869208 SGTC_2719 novobiocin 32.65 µM 0.983555601149721 0.160728512800741 no 572 0.162667032206568 781 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1431 4049-0260 9.09 µM 0.983418675580056 0.160762709733623 no 573 0.162700711239724 841 3854841 SGTC_959 1222-0044 107 µM 0.982968970408351 0.160875056272943 no 574 0.162811355325339 831 6083612 SGTC_2393 9031399 185.94 µM 0.98294174251649 0.160881860062303 no 575 0.162818055963263 825 1526623 YDL150W RPC53 SGTC_95 0471-0001 561.058 µM 0.978837521298457 0.161909583596696 no 576 0.163830133529775 779 4015405 SGTC_221 trifluoperazine 10.304 µM 0.977947453801031 0.162133025377246 no 577 0.164050156694539 944 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_192 3455-0609 60.9 µM 0.977189192296613 0.162323537018741 no 578 0.16423774878452 811 3769639 SGTC_2636 apigenin dimethyl ether 100 µM 0.975797715391062 0.162673521632977 no 579 0.16458235856795 808 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2460 5552655 174.22 µM 0.973872793463555 0.16315848706655 no 580 0.165059851931378 804 5401989 SGTC_2180 6301957 200 µM 0.972682782233846 0.163458768360461 no 581 0.165355492570671 865 845462 SGTC_703 3875-0075 71.8 µM 0.971346028357619 0.163796505715618 no 582 0.165687997582848 890 2850814 SGTC_3043 9092303 49.47 µM 0.970620479166659 0.163980008737552 no 583 0.165868652034348 768 25236084 SGTC_170 4197-0004 226 µM 0.969823557732353 0.164181716592975 no 584 0.166067224118759 766 218692 SGTC_324 1315-0088 19.6 µM 0.969405639820493 0.164287559601334 no 585 0.166171419756214 754 6787421 SGTC_1780 st038448 24.544 µM 0.968578425937704 0.16449719243043 no 586 0.166377785896602 832 728868 YDL195W SEC31 SGTC_2697 mebhydrolin 72.4 µM 0.968415579508432 0.164538481444913 no 587 0.166418430897512 859 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2387 9077560 195.08 µM 0.963833099133848 0.165703103012269 no 588 0.167564804656152 821 5303272 SGTC_984 1492-0255 2.91 µM 0.963122679286313 0.16588412981359 no 589 0.167742980825024 790 1585198 SGTC_1654 st012436 41.8 µM 0.961973333420603 0.166177272851096 no 590 0.168031499662274 801 4323132 SGTC_2371 9071574 200 µM 0.961365077269767 0.166332545162589 no 591 0.168184318588125 803 45596039 SGTC_302 1094-0063 18.9 µM 0.960813395010262 0.166473456596804 no 592 0.168323001132761 770 5440289 SGTC_3208 9114115 49.47 µM 0.960647454752853 0.166515856355723 no 593 0.168364729777639 735 650895 SGTC_499 genistein 192 µM 0.959940009818962 0.166696695363444 no 594 0.168542704091116 839 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3167 9103034 49.47 µM 0.959647710418275 0.166771450720112 no 595 0.168616274137273 796 5127859 SGTC_2438 5259590 200 µM 0.957653546678201 0.16728203366505 no 596 0.16911874417066 893 1201127 SGTC_3203 9113543 49.47 µM 0.957320851895409 0.167367314344307 no 597 0.169202666867507 786 17018012 SGTC_1234 0326-0494 15.5 µM 0.956704372880684 0.167525412353513 no 598 0.169358245173125 853 1547813 SGTC_1848 st056003 16.4 µM 0.955260318846833 0.16789612110834 no 599 0.169723034527187 912 146492 SGTC_3326 9140064 16.379 µM 0.955230237654347 0.167903848979348 no 600 0.169730638834497 819 1868434 SGTC_2674 ligustilide 100 µM 0.954970332599634 0.167970628232777 no 601 0.169796350047414 815 5319022 A signalling regulator. SGTC_508 roscovitine 141 µM 0.952948645056726 0.168490658333932 no 602 0.170308045668002 875 160355 A CDKinase inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.952604093913156 0.168579388896361 no 603 0.170395351092573 868 688669 SGTC_2205 7238770 200 µM 0.950522074919151 0.169116200038433 no 604 0.17092352133998 866 279867 SGTC_1784 st039334 36.3 µM 0.948165467220577 0.169725131802274 no 605 0.171522612093008 842 3496984 SGTC_3267 9137951 49.47 µM 0.94793109318237 0.169785769283551 no 606 0.171582267332911 842 16643986 SGTC_3215 9129942 49.47 µM 0.947078914479753 0.170006362866274 no 607 0.171799284149698 812 17682944 SGTC_1137 ixabepilone 100 µM 0.945915125500934 0.170307915993261 no 608 0.172095939040301 876 154225 A novel microtubule stabilizer. SGTC_34 0469-0683 81.75 µM 0.945389635200932 0.170444189705004 no 609 0.17222999589314 870 3690923 SGTC_745 0469-0705 296 µM 0.945157043504823 0.170504529251386 no 610 0.172289353196108 950 3486736 SGTC_2144 5628481 200 µM 0.94496604441199 0.170554088962642 no 611 0.172338105842658 839 2818399 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.943982785031501 0.170809367271636 no 612 0.172589222714083 914 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1084 voriconazole 435 nM 0.943406387858048 0.170959127772319 no 613 0.172736538529927 888 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1012 4112-3522 18 µM 0.943111342069698 0.171035819569423 no 614 0.172811977454458 897 3112398 SGTC_1125 tnp00248 1.32998 µM 0.942094669345156 0.171300253722026 no 615 0.173072086718301 983 24207736 SGTC_2749 bexarotene 57.39 µM 0.941203511341708 0.171532256638038 no 616 0.173300288832678 819 82146 An retinoic acid receptor inhibitor. SGTC_765 1319-0117 244 µM 0.94102074946971 0.171579861426202 no 617 0.173347113001864 813 3487746 YGL099W LSG1 SGTC_2059 5238311 157 µM 0.940928223962764 0.17160396516999 no 618 0.173370821399871 828 703021 SGTC_792 4534-1957 155 µM 0.938183218207512 0.172320048401052 no 619 0.174075130557449 873 1717904 SGTC_201 4262-0159 12.803 µM 0.937648710380988 0.172459705637354 no 620 0.174212484986762 813 1341029 SGTC_623 k072-0108 16.9 µM 0.935674588728401 0.172976133405113 no 621 0.174720378989382 858 5382803 SGTC_33 0986-0033 35.816 µM 0.933678912856592 0.173499200108559 no 622 0.175234772823551 835 2848082 SGTC_948 3448-0295 75.3 µM 0.931913842230035 0.173962663162366 no 623 0.175690526687876 905 678569 SGTC_3145 9085516 49.47 µM 0.930766296655153 0.174264401561845 no 624 0.175987233638916 830 25236195 SGTC_739 1486-1183 203 µM 0.930394303024774 0.174362285798004 no 625 0.176083483578964 903 4346692 SGTC_2757 clomiphene 4.22 µM 0.928580901650135 0.174839953715492 no 626 0.176553161610166 957 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1951 sophoraflavanone G 9.2 µM 0.925076942870528 0.17576528156242 no 627 0.177462942834036 879 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.923279682777919 0.176241104722371 no 628 0.177930736485796 899 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2612 dictamnine 15.46 µM 0.923115172588309 0.176284699349319 no 629 0.177973594267529 839 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_962 1254-0300 21.5 µM 0.923076714819426 0.176294891508024 no 630 0.177983614127627 879 7340576 SGTC_163 TUB2.036 7.546 µM 0.921575153125917 0.176693130019018 no 631 0.178375111914717 988 15992207 YJR013W GPI14 SGTC_1215 3852-0577 11.2 µM 0.921246972705673 0.176780244470875 no 632 0.178460749632256 962 2884876 SGTC_696 1560-0013 611 µM 0.920731227378277 0.176917202283054 no 633 0.178595384185656 892 1650269 SGTC_344 k064-0035 6.43 µM 0.919742732866799 0.177179887511071 no 634 0.178853607946978 850 5088750 SGTC_1379 2144-0755 36.5 µM 0.917956996541538 0.177655058098305 no 635 0.179320690037759 949 5392327 SGTC_3000 9075062 71.4286 µM 0.91734699590635 0.177817558620989 no 636 0.179480419076174 841 17057871 SGTC_2790 5423970 71.43 µM 0.917252453245491 0.177842752609961 no 637 0.179505183132116 917 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3101 9120531 49.47 µM 0.916538440799317 0.17803309732176 no 638 0.179692277517994 897 24824904 SGTC_648 0375-0473 33.3 µM 0.915929583609142 0.178195510690583 no 639 0.179851914571529 908 1713139 SGTC_1761 st044296 37 µM 0.915356806354262 0.178348384915292 no 640 0.180002173070977 895 1826700 SGTC_2170 morpholine 200 µM 0.914686616651284 0.178527363397543 no 641 0.180178086133238 898 121171 Reacts with secondary amines. SGTC_1396 3511-0007 98.6 µM 0.913918957331847 0.178732510721673 no 642 0.180379715805633 805 X1396 SGTC_3300 9124615 50.48 µM 0.912373751552389 0.179145897412648 no 643 0.180786001132782 886 24824903 SGTC_2553 4-methylesculetin 85.09 µM 0.911106255540065 0.179485437439979 no 644 0.181119695373862 914 5319502 SGTC_1046 2001-0062 216 µM 0.909926836976159 0.179801746141786 no 645 0.181430547748528 870 739778 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.907958808608132 0.18033033150298 no 646 0.181949992472932 744 4000243 SGTC_2641 levomentholum 100 µM 0.907478229636509 0.180459556384246 no 647 0.182076978439139 875 16666 SGTC_2602 kawain 100 µM 0.906768738600822 0.18065044054008 no 648 0.182264552323401 966 5369129 SGTC_3151 9099821 49.47 µM 0.904216725138591 0.181338090135639 no 649 0.182940246649744 885 17174189 SGTC_2875 9039966 71.43 µM 0.90119083644504 0.182155547866852 no 650 0.183743431147824 936 6463691 SGTC_189 3970-0742 2.116 µM 0.898912622819975 0.182772535263015 no 651 0.184349601941915 937 2891807 SGTC_2081 5214970 32.255 µM 0.897878761907538 0.183052956032081 no 652 0.184625094214667 939 2063512 SGTC_1433 4060-0023 7.6 µM 0.895921251148493 0.183584639097144 no 653 0.1851474116668 929 3840627 SGTC_287 k060-0039 29.6 µM 0.895057246779581 0.183819618719706 no 654 0.185378243347173 944 5861974 SGTC_539 4859-0462 2.54 µM 0.894376521454306 0.184004884596267 no 655 0.185560235068003 941 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_94 0334-0113 514.748 µM 0.893408217763277 0.18426861788963 no 656 0.185819301738391 932 6795178 SGTC_2067 5224629 34.075 µM 0.889916298334531 0.185221651342026 no 657 0.186755415879859 901 2835000 SGTC_2224 6650123 117.647 µM 0.887363240034347 0.185920379286678 no 658 0.18744168396285 905 2908370 SGTC_1066 ketoconazole 628 nM 0.884973298579435 0.186575944056056 no 659 0.188085516375675 976 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1267 0828-0272 9.49 µM 0.884816432677954 0.18661902262389 no 660 0.188127822561597 945 745334 SGTC_315 k915-0449 187 µM 0.883077852426954 0.187096884420134 no 661 0.188597104753166 999 20970215 YNL149C PGA2 SGTC_1676 st018489 23.4 µM 0.882031371757259 0.187384882017768 no 662 0.188879921232785 909 3696235 SGTC_945 3381-0768 11.3 µM 0.881730960122121 0.187467607654036 no 663 0.188961157185924 975 1126236 YIL048W NEO1 SGTC_2094 5332512 191.667 µM 0.880715832391187 0.187747314682348 no 664 0.189235822645639 974 755774 SGTC_1075 aripiprazole 15.2 µM 0.878890313064552 0.188250964175367 no 665 0.189730375732591 984 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1696 st025591 34.7925 µM 0.878736407578865 0.188293463816319 no 666 0.189772106708898 947 2787147 SGTC_1466 k213-0079 57.5 µM 0.878205368628561 0.188440150977026 no 667 0.18991613954251 952 3657981 SGTC_1024 4507-0395 26 µM 0.87799037547408 0.188499557873555 no 668 0.189974470894448 890 4201836 SGTC_1553 gossypol 38.6 µM 0.874601263818184 0.189437562428588 no 669 0.190895449946834 864 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2307 7538926 6.34 µM 0.874267611589496 0.189530062433565 no 670 0.190986266619809 939 96582 SGTC_168 3970-0862 530.542 µM 0.873978291896196 0.189610294410662 no 671 0.1910650378854 1046 3135186 SGTC_248 streptozotocin 5.23457 mM 0.871516967494482 0.190293695190549 no 672 0.191735972745087 995 5300 DNA alkylating agent. SGTC_1975 st070967 30.8 µM 0.871171637634435 0.190389698888599 no 673 0.191830221827925 1008 261391 SGTC_2702 st077768 96.8 µM 0.871099932170556 0.190409637151103 no 674 0.191849795582925 840 6484119 SGTC_1493 4348-0038 111 µM 0.871011044910328 0.190434354725772 no 675 0.191874061225459 1010 800424 SGTC_681 1642-0006 26.6 µM 0.868688433282233 0.191080919714239 no 676 0.192508784846117 960 4446530 SGTC_840 0245-0196 390 µM 0.867990476788241 0.191275478492782 no 677 0.192699773023672 986 3827528 SGTC_2328 6201408 200 µM 0.867041943268031 0.191540081405812 no 678 0.192959514392114 879 2890418 SGTC_3100 9120536 49.47 µM 0.86623405593213 0.191765626398794 no 679 0.19318091048258 844 16421196 SGTC_1448 4255-0083 152 µM 0.866114091635316 0.19179913174513 no 680 0.193213799108312 1006 5399660 SGTC_2587 piperic acid 92.2 µM 0.864935912158365 0.192128381003587 no 681 0.193536982648522 875 5370536 SGTC_334 1502-1024 68.5 µM 0.864233202273291 0.192324921989796 no 682 0.193729898165786 978 3296216 SGTC_1438 4092-1045 4 µM 0.863682975907743 0.192478900646238 no 683 0.19388103406714 979 1351342 SGTC_2247 cerulenin 830 nM 0.863648301157183 0.192488606760827 no 684 0.193890560916605 942 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_953 1188-0045 9.7 µM 0.861790629700404 0.193009041270537 no 685 0.194401371104774 967 6144426 SGTC_1561 5-methoxyflavone 52.9 µM 0.858091915997667 0.194047806946041 no 686 0.195420855427222 934 94525 SGTC_1855 st056195 39.6 µM 0.855894843576801 0.194666453414943 no 687 0.196027973701276 931 4028379 SGTC_116 0155-0182 31.788 µM 0.854811118919489 0.19497204748828 no 688 0.196327860850899 1007 771486 SGTC_2616 abietic acid 100 µM 0.854432616083523 0.195078848292323 no 689 0.196432665251605 1012 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_290 2043-6722 48.1 µM 0.853806876890112 0.195255488877152 no 690 0.19660600176202 965 773758 YLR208W SEC13 SGTC_1928 4'-methoxychalcone 40.3 µM 0.852632401073398 0.195587295202345 no 691 0.196931594323599 1014 641818 SGTC_1333 1482-0047 286 µM 0.851970979474643 0.195774306928287 no 692 0.197115099675422 1001 3811116 SGTC_3144 9087057 49.47 µM 0.851708259894049 0.195848618917066 no 693 0.197188017515361 927 17249618 SGTC_869 0564-0080 44.1 µM 0.850571957496251 0.196170226718846 no 694 0.197503586234572 933 6843321 SGTC_2771 fluoxetine 41.05 µM 0.846339277441951 0.197371018186497 no 695 0.198681751260438 942 3386 A selective serotonin reuptake inhibitor. SGTC_2670 beta-carotene 100 µM 0.845542688700898 0.197597502696127 no 696 0.198903954381381 934 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1905 st060207 84.5 µM 0.844751381713197 0.197822640979703 no 697 0.19912483242205 961 1948547 SGTC_980 1473-0395 201 µM 0.843081689486954 0.198298200814229 no 698 0.199591379282607 915 768876 SGTC_2897 9048598 12.99 µM 0.842835212523968 0.198368460500325 no 699 0.199660305769112 961 6467404 SGTC_1496 4469-0713 57.4 µM 0.840785852776214 0.198953223878207 no 700 0.200233957019846 970 746691 SGTC_1231 0242-0792 125 µM 0.839528888388684 0.1993123989648 no 701 0.200586292616374 977 3707635 SGTC_2688 kanamycin b 96.69 µM 0.83761182517506 0.199860947272532 no 702 0.201124374644673 1232 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3024 9090631 49.47 µM 0.833692781479078 0.20098516374021 no 703 0.202227063440034 973 25236383 SGTC_425 3825-7017 13.1 µM 0.833276429541234 0.201104820930674 no 704 0.20234442319874 1002 3397440 SGTC_1220 1838-0075 193 µM 0.831101271183718 0.201730643476769 no 705 0.202958210844046 987 5529645 SGTC_2131 toluylene red 5.2905 µM 0.829462430090657 0.202202929802262 no 706 0.203421393775661 960 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2751 anetholtrithion 17.25 µM 0.828758540356106 0.202405981840112 no 707 0.203620526404403 956 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1722 st034304 3.6505 µM 0.828360655437011 0.202520814170756 no 708 0.203733140712365 995 4036148 YLR033W RSC58 SGTC_2721 ifenprodil 61.44 µM 0.828083282878036 0.20260088883765 no 709 0.203811668082759 985 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1942 st076330 65.2 µM 0.826701290865615 0.203000137977964 no 710 0.204203194765435 1052 24208414 SGTC_2219 9098279 200 µM 0.825472630672182 0.203355484712139 no 711 0.204551657465486 1012 902349 SGTC_1518 st038567 90.8 µM 0.825079939481638 0.203469135045648 no 712 0.204663103950392 1003 77966 SGTC_761 k216-0224 480 µM 0.824826220739568 0.203542584949683 no 713 0.204735129003084 1062 1340404 SGTC_3027 9089541 49.47 µM 0.823384570002273 0.203960233466325 no 714 0.205144667401954 1012 9943819 SGTC_2030 5175110 200 µM 0.823022686955869 0.204065151684929 no 715 0.205247546083141 1019 2831986 SGTC_186 3455-3465 67.277 µM 0.822153296023857 0.204317339478992 no 716 0.205494827948937 958 755278 SGTC_1347 1493-0251 600 nM 0.822051833428942 0.204346783236578 no 717 0.205523698594682 1051 3986378 SGTC_928 2764-0428 58.7 µM 0.821803675761698 0.204418807553967 no 718 0.205594320696205 1025 662578 SGTC_2965 9082772 38.63 µM 0.821788189009349 0.204423302869685 no 719 0.205598728480611 1050 16459634 SGTC_3230 9131665 49.47 µM 0.821298765665438 0.204565397340197 no 720 0.205738055310856 956 15943720 SGTC_1753 st043925 64 µM 0.820863135089554 0.204691923559382 no 721 0.205862115777608 1035 670181 SGTC_2523 spermine 47.74 µM 0.819215515590306 0.205170885327561 no 722 0.20633173207823 1000 1103 A DNA binding polyamine. SGTC_2019 4016004 108 µM 0.8187859352569 0.205295873378442 no 723 0.206454278404661 982 45595336 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.813235125410525 0.206914967297786 no 724 0.208041632089347 948 61125 An anti-inflammatory. SGTC_2968 9090663 33.37 µM 0.812224305117566 0.207210620806961 no 725 0.208331467759798 966 25236811 SGTC_1604 st002052 72.4 µM 0.812019412710074 0.207270579960504 no 726 0.208390246222616 1022 6254834 YHR062C RPP1 SGTC_2997 9067075 71.4286 µM 0.811256696087201 0.207493869431248 no 727 0.208609136339948 1023 27209819 SGTC_1316 1272-0050 65.9 µM 0.809849094423996 0.207906325638278 no 728 0.209013456090834 1019 7340392 SGTC_1358 1509-0022 2.48 µM 0.806467830208567 0.208899081584968 no 729 0.209986574916994 1045 3258434 SGTC_2297 7971671 152.32 µM 0.804289328518788 0.209540177110806 no 730 0.210614949645833 1019 909016 SGTC_2083 5306046 65.942 µM 0.802877550513488 0.209956256382154 no 731 0.211022756412414 1042 539837 SGTC_1503 4585-0012 61.3 µM 0.802178171357592 0.21016255714686 no 732 0.211224950688317 1032 2922052 SGTC_135 0933-0004 26.348 µM 0.801796583468599 0.210275166984045 no 733 0.211335317645647 962 21230617 YGL099W LSG1 SGTC_819 1013-0258 27.7 µM 0.801165071853706 0.210461609264587 no 734 0.211518044426512 1037 5753198 SGTC_1224 0823-0416 294 µM 0.800353280695213 0.210701418271088 no 735 0.211753070613248 1044 3598164 SGTC_1563 conessine 56.1 µM 0.800307802375427 0.21071485763719 no 736 0.21176624181424 1141 441082 An anti-amoebic, histamine inhibitor. SGTC_1652 st011932 78 µM 0.799357174021516 0.21099589433449 no 737 0.212041667717783 1020 1551076 SGTC_1428 4049-0204 61.7 µM 0.799310687297667 0.211009642956903 no 738 0.212055141703784 1073 X1428 SGTC_2238 6671620 73.2395 µM 0.798717088064403 0.211185248313326 no 739 0.21222723801436 1067 729941 SGTC_747 3448-8087 38.7 µM 0.798637802907731 0.211208709841943 no 740 0.212250230548657 1036 5168703 SGTC_3325 9138760 55.175 µM 0.798627303002013 0.211211817017715 no 741 0.21225327560915 1018 43844959 SGTC_323 4013-0906 34.3 µM 0.79800123486406 0.211397134110446 no 742 0.212434886754368 1072 2910086 SGTC_2662 daunorubicin 22.37 µM 0.797938601745166 0.211415678844677 no 743 0.212453060493831 1015 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1177 0983-0204 23.6 µM 0.797004305660581 0.211692423098243 no 744 0.212724265357249 1080 766818 SGTC_3254 9136651 49.47 µM 0.794793648757562 0.212348077001676 no 745 0.213366773051848 1077 16454030 SGTC_3294 9122953 26.2835 µM 0.792753435485174 0.212954231039996 no 746 0.213960745426649 1107 16459826 SGTC_2857 9024691 58.44 µM 0.792393486820024 0.213061277650738 no 747 0.214065637981972 1036 16478292 SGTC_2679 rapamycin 1 nM 0.791138635434156 0.213434708448305 no 748 0.214431547879493 1094 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_119 0121-0043 24.815 µM 0.790902514754162 0.213505018142844 no 749 0.214500440407213 1156 1092378 SGTC_2062 5245942 200 µM 0.790875052495699 0.213513196460303 no 750 0.214508453858778 1148 1376160 SGTC_1568 digitonin 820 nM 0.789610848321052 0.213889876681127 no 751 0.214877535390825 1075 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3106 9121286 49.47 µM 0.788377965988871 0.214257596685981 no 752 0.215237827609997 1035 15943471 SGTC_2929 9013348 24.6 µM 0.788189637760647 0.214313799904378 no 753 0.215292894692584 1024 2995952 SGTC_1286 0929-0070 131 µM 0.78691897841119 0.214693229694811 no 754 0.215664648476774 1077 1420408 SGTC_1414 3917-0015 5.4 µM 0.786901378640071 0.214698487877079 no 755 0.215669800211767 1064 6618702 SGTC_2394 5221648 200 µM 0.785874166205092 0.215005511849193 no 756 0.215970605335096 1134 788586 SGTC_348 k064-0012 10.7 µM 0.784379286815745 0.215452772186265 no 757 0.216408794302291 1018 5066323 SGTC_2226 7298446 200 µM 0.777502332042902 0.217517262278755 no 758 0.218431229558854 1052 3283010 SGTC_342 k048-0088 23.3 µM 0.777458466805171 0.217530467347299 no 759 0.218444164674242 1075 6820570 SGTC_2796 7949634 45.45 µM 0.777062710815516 0.217649625541369 no 760 0.218560886352936 1019 2971588 SGTC_907 3448-6986 75.5 µM 0.775876897825943 0.218006887458288 no 761 0.218910837179998 1101 590582 SGTC_3031 9088762 49.47 µM 0.774971107361787 0.218280011760456 no 762 0.219178366258415 1089 205253 SGTC_1223 0764-0573 147 µM 0.774963324289768 0.218282359455307 no 763 0.219180665836111 1126 1609797 SGTC_1416 3966-0321 25.3 µM 0.7731577364757 0.218827392091877 no 764 0.219714517510208 1111 582530 YLR208W SEC13 SGTC_2528 xanthyletin 44.79 µM 0.77261799491565 0.218990469745681 no 765 0.21987424578164 1069 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2596 sinensetin 100 µM 0.771003233223588 0.21947877142305 no 766 0.220352507579366 1045 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1152 3909-8331 15.9 µM 0.7703219399859 0.219684981023671 no 767 0.220554472467237 1045 16001939 SGTC_25 0118-0223 35.662 µM 0.769597102549012 0.219904492398632 no 768 0.220769462147977 1085 5333628 SGTC_1288 0973-0013 65.5 µM 0.76505397679282 0.221283206440827 no 769 0.22211970185702 1111 4315430 SGTC_737 1950-0117 57.9 µM 0.763529396570828 0.221746980281316 no 770 0.222573868834504 1086 5393513 SGTC_332 4112-0506 40.9 µM 0.761665151857363 0.222314833222007 no 771 0.223129939496201 1080 2790355 SGTC_1917 st066507 28.5 µM 0.761423360480816 0.222388544123337 no 772 0.223202119417775 1069 3156428 SGTC_349 k015-0014 24 µM 0.760920438705758 0.222541906135534 no 773 0.22335229494226 1053 2196908 SGTC_783 0848-0141 92.7 µM 0.76060877626732 0.222636975384065 no 774 0.223445388105324 1035 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2074 5212007 75.395 µM 0.758521817972985 0.223274175649018 no 775 0.224069328344389 1045 758611 SGTC_228 caffeine 993.056 µM 0.758296394106834 0.223343065220225 no 776 0.224136782740703 1058 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1304 1165-0502 251 µM 0.756181124366945 0.223990080977367 no 777 0.224770304114212 1092 767425 SGTC_2870 9038528 12.99 µM 0.755614553385013 0.224163563566072 no 778 0.224940163858234 1076 6463316 SGTC_617 3770-0098 35 µM 0.754961597163725 0.224363591705946 no 779 0.225136012378655 1063 5962639 SGTC_80 0159-0065 512.242 µM 0.754301217295683 0.224565997033544 no 780 0.225334185778785 1045 1548079 SGTC_2793 7325131 81.82 µM 0.753267510499028 0.224883034338809 no 781 0.225644589093335 1072 4176441 SGTC_1977 st070720 65.3 µM 0.752995645512592 0.224966457302002 no 782 0.225726265358551 1064 682188 SGTC_2085 5307070 144.047 µM 0.752902599379782 0.224995012944123 no 783 0.225754223003877 1073 2840351 SGTC_1922 5578187 25 µM 0.752690887534901 0.22505999447169 no 784 0.225817843528046 1090 1350412 SGTC_247 mechlorethamine 29.705 µM 0.749533487508287 0.226030368420269 no 785 0.226767861325104 1059 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1920 st075728 45.7 µM 0.749009085166455 0.226191763396277 no 786 0.226925864787884 1091 3400306 SGTC_488 nitrendipine 139 µM 0.748096171242406 0.226472885627881 no 787 0.227201075637823 1124 4507 Dihydropyridine L-type calcium channel blocker. SGTC_372 0155-0182 15.9 µM 0.747213985051547 0.226744732911946 no 788 0.227467201810324 1136 771486 SGTC_2915 7971052 15.16 µM 0.746972419947314 0.226819203738916 no 789 0.227540104560135 998 5741558 SGTC_8 0354-0001 70 µM 0.746012319933213 0.227115324256726 no 790 0.227829986426026 1167 4993152 SGTC_371 0195-0006 7.36 µM 0.745748530546991 0.22719672210638 no 791 0.227909668422285 1006 3928593 SGTC_2823 7987624 58.44 µM 0.745342004914656 0.227322196462787 no 792 0.228032496983739 1101 2239440 SGTC_1558 st069300 45.6 µM 0.745027850559834 0.227419187113242 no 793 0.228127441778763 1059 24208000 SGTC_2813 7971799 71.43 µM 0.744857033651356 0.227471934165299 no 794 0.228179075972248 1094 2234054 SGTC_3251 9135047 49.47 µM 0.742654914319211 0.228152549720129 no 795 0.228845316268417 1098 17682963 SGTC_1756 st041558 35.5 µM 0.742206797034675 0.228291190737073 no 796 0.228981025510236 1218 3955792 SGTC_3218 9131285 49.47 µM 0.741741414884641 0.228435223365592 no 797 0.229122011084066 1135 17156417 SGTC_359 0081-0058 15.9 µM 0.74080257373534 0.228725943692784 no 798 0.229406577211466 1123 3494159 SGTC_2353 9059630 146.67 µM 0.740558321355697 0.228801612604601 no 799 0.229480643444694 1137 4779114 SGTC_384 k007-0144 5.16 µM 0.739653862196155 0.229081934618595 no 800 0.229755025113542 1126 6824886 SGTC_2069 5228469 200 µM 0.736641722544981 0.230016884822705 no 801 0.23067012769129 1105 2835210 SGTC_2161 5662504 8.5105 µM 0.736453888318776 0.23007525809524 no 802 0.230727260008351 1080 2859334 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.735419731441948 0.230396791597534 no 803 0.23104195431554 1000 6708630 An antioxidant. SGTC_512 prima-1 270 µM 0.734183809612851 0.230781385885474 no 804 0.231418359810933 1134 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2943 9068529 45.32 µM 0.734141259033801 0.230794633161169 no 805 0.23143132486536 1198 3270634 SGTC_254 nsc-64875 3.808 µM 0.732610098468615 0.231271612035925 no 806 0.231898135062401 1161 56993 SGTC_2792 7535235 81.82 µM 0.732426766725095 0.231328759390001 no 807 0.231954063174688 1102 1281891 SGTC_2001 4023502 57.655 µM 0.731998961500763 0.231462143556059 no 808 0.232084600817095 1123 108941 YCR052W RSC6 SGTC_106 0092-0003 11.579 µM 0.731620556671098 0.231580161045679 no 809 0.23220009882737 1091 1072148 SGTC_517 1365-0151 113 µM 0.731256148963027 0.231693844786832 no 810 0.232311354816022 1150 768657 SGTC_2905 7799065 20.05 µM 0.730280017670057 0.231998520207863 no 811 0.232609519973095 1101 1296806 SGTC_362 0310-0100 9.03 µM 0.729514238715403 0.232237695374975 no 812 0.232843580584205 1139 790235 SGTC_587 k089-0003 57 µM 0.729022047274253 0.232391493564275 no 813 0.23299408812663 1090 9659696 SGTC_2663 amphotericin b 100 µM 0.728627313459663 0.232514879475501 no 814 0.23311483306906 1134 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1036 k216-0215 33.5 µM 0.727976114551223 0.232718510850142 no 815 0.233314103908906 1153 622330 SGTC_2282 7944268 200 µM 0.726318621484301 0.233237259605193 no 816 0.23382173313167 1159 2970414 SGTC_1042 0350-0096 82 µM 0.72545925874065 0.233506468426605 no 817 0.234085165111704 1119 3122515 SGTC_1487 3970-0795 2.82 µM 0.725144785248714 0.233605025222285 no 818 0.234181605949404 1167 3765103 SGTC_2150 5556613 200 µM 0.722704756804816 0.234370519666785 no 819 0.23493064624947 1144 743190 SGTC_3293 9120939 62.045 µM 0.721927724589153 0.234614584093001 no 820 0.235169457355974 1149 934087 SGTC_2958 9077254 16.72 µM 0.721398137762362 0.23478100687976 no 821 0.2353322960166 1177 16457351 SGTC_244 nsc-207895 1.295 µM 0.720882479245167 0.234943115380153 no 822 0.235490911756531 1040 42640 SGTC_2007 4011539 71.82 µM 0.720654740220827 0.235014729794199 no 823 0.235560982693532 1149 45595301 SGTC_3153 9100258 49.47 µM 0.719486996147551 0.235382125940714 no 824 0.235920455825041 1108 25236848 SGTC_1411 3909-8223 150 µM 0.719309520334143 0.235437991195836 no 825 0.235975115644435 1182 X1411 SGTC_491 tetrandrine 80.3 µM 0.718260758757881 0.235768266261565 no 826 0.236298260503286 1132 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_880 0833-0487 87.2 µM 0.718151989094066 0.235802534523089 no 827 0.236331788598119 1145 76075 SGTC_1123 mangostin 811.285 nM 0.716849063101723 0.236213239293093 no 828 0.236733617229493 1107 5281650 An antioxidant. SGTC_1102 cgs 12066b 26.1 µM 0.716621596750298 0.236284980987019 no 829 0.236803807451999 1121 6438352 A 5-HT1B full agonist. SGTC_2496 diffractaic acid 79.83 µM 0.714855953776146 0.236842263338971 no 830 0.237349028115878 1174 94870 An apoptosis inducer which activates caspases. SGTC_2849 9019321 12.99 µM 0.713646417864982 0.237224440714782 no 831 0.23772292351591 1128 16489627 SGTC_673 1082-0474 110 µM 0.712763363566661 0.237503673405182 no 832 0.237996099859666 1214 3098046 SGTC_533 1222-0222 6.71 µM 0.711025847340257 0.238053623858776 no 833 0.238534109434155 1217 3982874 SGTC_2529 gangaleoidin 93.61 µM 0.710827491056597 0.238116451013592 no 834 0.238595571362242 1198 4565183 SGTC_2446 5162541 200 µM 0.710232464703967 0.238304973518793 no 835 0.238779995966224 1124 1549321 SGTC_1015 4130-4525 82 µM 0.709357299149703 0.238582401156625 no 836 0.239051389558461 1176 1363237 SGTC_1806 st050005 60.3 µM 0.707712079847971 0.239104414148185 no 837 0.239562037133867 1153 5194765 SGTC_1073 triclabendazole 3.09 µM 0.70706549890089 0.239309739104987 no 838 0.239762887544839 1226 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2175 5807670 165.306 µM 0.706818476779471 0.239388207614137 no 839 0.239839645410965 1138 241186 SGTC_2762 leflunomide 42.06 µM 0.706175649535686 0.239592472566854 no 840 0.240039455712476 1160 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1475 4092-1048 11.7 µM 0.705439192077572 0.239826606371349 no 841 0.240268480644208 1195 2881759 SGTC_1273 0849-0096 14.1 µM 0.705028152891857 0.23995733778346 no 842 0.24039635814098 1179 5286025 SGTC_2120 5538279 151.968 µM 0.703802622862386 0.240347349367323 no 843 0.240777850042479 1182 2058197 SGTC_3277 9138724 49.47 µM 0.703331563404116 0.24049735073651 no 844 0.240924572456154 1078 15943418 SGTC_1830 st055982 50.3 µM 0.700604495849072 0.241366742910091 no 845 0.241774935958176 1143 455313 An antimicrobial agent. SGTC_1550 gossypolone 36.6 µM 0.697445177165331 0.242376068375118 no 846 0.242762118600264 1208 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_435 c-PAF 6.7 µM 0.697067332161937 0.242496933583109 no 847 0.242880328563056 1164 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1972 st070201 17.4 µM 0.695526360275605 0.242990198165271 no 848 0.243362748685709 1174 2829099 SGTC_1728 st035614 33.7865 µM 0.694624961979734 0.24327898685797 no 849 0.243645182314788 1174 15945546 SGTC_1141 3253-0389 52.6 µM 0.69400419300303 0.243477975751384 no 850 0.243839789693575 1182 5402031 SGTC_1056 3448-1962 115 µM 0.692444315375911 0.243978385867069 no 851 0.244329172067093 1173 715507 SGTC_661 1304-0007 33.6 µM 0.692347030122916 0.244009613432557 no 852 0.244359711019542 1206 3117130 SGTC_873 0591-4978 488 µM 0.690733888650894 0.244527729394854 no 853 0.24486639428652 1253 3305145 SGTC_3316 9136639 10.545 µM 0.690071187978451 0.244740750159697 no 854 0.245074710470036 1197 4903665 SGTC_3340 9146634 11.102 µM 0.688303326865169 0.245309505882115 no 855 0.245630893563485 1208 4907387 SGTC_3226 9131256 49.47 µM 0.686630887517422 0.245848215854752 no 856 0.246157679577471 1124 17178073 SGTC_2244 6635614 200 µM 0.68554528799522 0.246198238235088 no 857 0.246499946421018 1106 836499 SGTC_1022 4477-0945 21.3 µM 0.685024607637459 0.246366212390448 no 858 0.246664196488408 1196 4648966 SGTC_2234 tolnaftate 200 µM 0.683524755707387 0.246850415440971 no 859 0.247137656362532 1199 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2871 9038510 12.99 µM 0.682864599893723 0.247063697452637 no 860 0.24734620240868 1230 4945164 SGTC_2512 diallyl trisulfide 49.23 µM 0.682837726867771 0.247072381631608 no 861 0.247354693704706 1226 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1678 st019265 80.2 µM 0.682676760893164 0.247124402166673 no 862 0.247405558739281 1232 5367020 SGTC_983 1491-0821 12.2 µM 0.680504685570788 0.24782693994923 no 863 0.248092478002003 1184 46495113 SGTC_1226 3909-7979 35.4 µM 0.68035283081453 0.247876095817615 no 864 0.248140540121571 1229 6615510 SGTC_2714 st079313 56.9 µM 0.680161362487629 0.247938082141926 no 865 0.248201147037292 1218 2939799 SGTC_249 wiskostatin 11.211 µM 0.67967921064873 0.248094211542806 no 866 0.24835380116306 1230 2775510 A n-wasp and actin depolymerizer. SGTC_2689 tacrolimus 100 µM 0.679013659511885 0.248309815056343 no 867 0.248564603550464 1224 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2088 5278280 127.392 µM 0.677768831510613 0.248713341753324 no 868 0.248959138109558 1261 791502 SGTC_2819 7996655 46.38 µM 0.677378922075891 0.248839807598921 no 869 0.249082784126069 1118 6456960 SGTC_1940 st075990 51.1 µM 0.674490759476595 0.249777638601207 no 870 0.249999679274407 1325 1084979 SGTC_269 exalamide 29 µM 0.674423662142039 0.249799448425838 no 871 0.250021001703373 1201 3316 A derivative of salicylamide. SGTC_2835 9006588 71.43 µM 0.674406480773056 0.249805033350436 no 872 0.250026461814927 1229 2345538 SGTC_464 bw-b 70c 158 µM 0.673563094345392 0.250079263506249 no 873 0.250294561521954 1248 5353454 SGTC_3265 9137266 49.47 µM 0.672725238634414 0.250351853388728 no 874 0.250561053947014 1183 17224265 SGTC_2313 7726885 200 µM 0.672322609262756 0.250482901754407 no 875 0.250689169640934 1216 726423 SGTC_1524 corynanthine 62.1 µM 0.67091305276449 0.250941972400322 no 876 0.251137960308384 1267 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_32 0928-0142 34.1 µM 0.670814607233196 0.250974051207125 no 877 0.251169320388206 1205 2244242 SGTC_1832 st054113 55 µM 0.670108128943119 0.251204323180357 no 878 0.251394431633853 1220 1251267 SGTC_1040 k898-0338 155 µM 0.669718007812151 0.251331528477881 no 879 0.25151878496854 1277 20969351 SGTC_459 nigericin 15.3 µM 0.667653971806931 0.252005107058172 no 880 0.252177248713732 1294 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.667198974436208 0.252153719165524 no 881 0.252322523068109 1272 364106 SGTC_580 1123-0028 41 µM 0.666722524764704 0.252309387594936 no 882 0.252474694121157 1296 1677248 YPR107C YTH1 SGTC_415 dibenzyl ketone 100 µM 0.666546560443692 0.252366892498206 no 883 0.252530906776318 1244 7593 SGTC_2110 5483698 200 µM 0.666158445734546 0.252493752282194 no 884 0.25265491520942 1247 2848765 YHR062C RPP1 SGTC_3337 9144342 33.5465 µM 0.665645119823534 0.252661590394431 no 885 0.252818979737788 1243 17682949 SGTC_1657 st012939 43.4 µM 0.665148806897407 0.252823921759184 no 886 0.252977660044556 1270 24207257 SGTC_3042 9091578 49.47 µM 0.664311723259909 0.253097834922127 no 887 0.253245409661497 1214 25236497 SGTC_2123 5259487 200 µM 0.662413139924094 0.253719673468424 no 888 0.253853242434171 1225 2173474 SGTC_816 0325-0417 81.3 µM 0.661950067130663 0.253871464223176 no 889 0.254001611593323 1235 68101 SGTC_52 0329-0193 875 nM 0.66184425341245 0.253906155619113 no 890 0.254035520839098 1315 3739292 SGTC_812 4251-0442 148 µM 0.661837262923358 0.253908447562911 no 891 0.254037761106862 1242 5723007 SGTC_2687 chenodiol 100 µM 0.661769877829737 0.25393054140178 no 892 0.254059356787287 1263 5702181 A cholesterol synthesis inhibitor. SGTC_2044 5102272 200 µM 0.661047580526364 0.254167427460647 no 893 0.254290900234465 1230 592666 SGTC_246 cycloheximide 667 µM 0.660454386751731 0.254362059107246 no 894 0.254481140274427 1148 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1262 0737-0114 49.6 µM 0.660082648294198 0.254484069289369 no 895 0.254600396548575 1284 765919 SGTC_3338 9144300 39.5675 µM 0.659182857581526 0.254779521099309 no 896 0.254889176781224 1244 4901274 SGTC_183 3914-0051 30.55 µM 0.659071110250034 0.254816226554233 no 897 0.254925053107042 1245 1596232 SGTC_992 3909-8734 162 µM 0.657664123011583 0.255278613982184 no 898 0.255376990404505 1256 4288319 SGTC_2006 4011487 200 µM 0.656373460339272 0.255703158323571 no 899 0.255791931115919 1291 45595294 SGTC_475 α-linolenic acid 10 µM 0.65586691744934 0.2558698787721 no 900 0.2559548778901 1345 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1405 3909-7894 12 µM 0.655127597670908 0.256113315779875 no 901 0.256192802455562 1268 7104060 SGTC_3171 9103192 49.47 µM 0.65488937327896 0.256191782030456 no 902 0.256269491315839 1294 13018434 SGTC_2676 harmalol 100 µM 0.654265128517081 0.256397454951665 no 903 0.256470504059406 1269 5459187 A monoamine oxidase inhibitor SGTC_1883 5-benzylidenerhodanine 20 µM 0.653251597941395 0.256731570907872 no 904 0.256797045406285 1253 1273210 SGTC_1369 1866-0067 208 µM 0.651357401783968 0.257356610264231 no 905 0.257407901030394 1291 3531355 SGTC_704 1310-0270 142 µM 0.64981202785485 0.257867131775402 no 906 0.257906824321749 1245 5718033 SGTC_2767 sibutramine 71.45 µM 0.648286180764716 0.258371717599947 no 907 0.258399935195358 1333 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_215 1287-0124 461.5 µM 0.648003580348091 0.258465227488786 no 908 0.258491317286169 1288 5560863 SGTC_3047 9092122 49.47 µM 0.647732643713695 0.258554894396409 no 909 0.258578943473189 1237 17173831 SGTC_1420 4'-methoxyflavone 42 µM 0.647467266550237 0.258642737002631 no 910 0.258664786528141 1265 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1451 4152-0210 104 µM 0.64668387533408 0.258902137757388 no 911 0.25891828055584 1284 659563 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.644024267277532 0.259783804678598 no 912 0.259779848913346 1152 88881 An O-methylated flavonoid and antioxidant. SGTC_804 1595-0054 20.9 µM 0.643899792621612 0.259825106266545 no 913 0.259820208140508 1279 761523 Stimulates phospholipase C. SGTC_2440 5628896 157.78 µM 0.643831034339185 0.259847922212706 no 914 0.259842503472577 1305 5522048 SGTC_735 3076-0345 636 µM 0.642954210631021 0.260138967771234 no 915 0.260126905938907 1318 2888990 SGTC_542 3381-0244 89.3 µM 0.64115239761054 0.260737573585845 no 916 0.260711836905933 1293 1112843 SGTC_3118 9124250 49.47 µM 0.640108517131682 0.261084699886594 no 917 0.261051026093321 1218 1504786 SGTC_521 r062-0005 13.8 µM 0.637083324475535 0.26209202098931 no 918 0.262035284944267 1216 2832033 SGTC_416 estradiol valerate 100 µM 0.636727216357503 0.262210727883549 no 919 0.262151271198837 1281 13791 A steroid. SGTC_2364 9055074 200 µM 0.636691123557285 0.26222276077867 no 920 0.262163028278559 1256 6470630 SGTC_1603 st002045 67.8 µM 0.635558599153666 0.262600474121687 no 921 0.262532080597942 1278 5887985 SGTC_2575 plumbagin 510 nM 0.634919428757498 0.262813769578493 no 922 0.262740482457678 1257 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1794 st048918 76.9 µM 0.632146346596736 0.263740190713392 no 923 0.263645626405222 1234 672303 SGTC_3188 9110789 49.47 µM 0.631502694596006 0.263955457523438 no 924 0.263855943959657 1324 849217 SGTC_1173 0443-0020 122 µM 0.62983505152867 0.264513610287061 no 925 0.26440125500371 1291 5331295 SGTC_309 k408-0051 1.48 µM 0.629573527737035 0.264601195587429 no 926 0.264486823996148 1282 3640463 SGTC_484 loperamide 105 µM 0.629349325504507 0.264676293500692 no 927 0.264560192819108 1282 3955 An opioid-receptor agonist. SGTC_319 1348-1596 45.5 µM 0.62930140625471 0.264692345753295 no 928 0.264575875446388 1363 5380505 SGTC_181 1447-1644 8.07 µM 0.628915698329038 0.2648215703342 no 929 0.264702124060601 1267 534600 SGTC_3062 9077494 49.47 µM 0.62740238392296 0.265328888989924 no 930 0.265197752738874 1301 16459633 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.626609023077769 0.265595049690617 no 931 0.265457776113914 1331 1273210 SGTC_538 2922-0838 53.3 µM 0.625807751051056 0.265864001853169 no 932 0.265720523609145 1348 777039 SGTC_3109 9122853 49.47 µM 0.624817014252756 0.266196739821267 no 933 0.266045581262315 1372 1234709 SGTC_283 0987-0079 11.7 µM 0.621127724753422 0.267437635442819 no 934 0.267257794396042 1317 411556 SGTC_616 4092-0450 108 µM 0.620108615449886 0.267780927254464 no 935 0.267593140208913 1341 787165 SGTC_1758 st042942 75.2445 µM 0.619109668738983 0.268117642538461 no 936 0.267922057107666 1280 669317 SGTC_335 4077-0256 27.6 µM 0.616874734409645 0.268871743471612 no 937 0.268658676463789 1321 3121989 SGTC_1773 st048542 73.5835 µM 0.616701216920503 0.268930335442887 no 938 0.268715909206454 1254 3237138 SGTC_1809 st050081 57.6 µM 0.616568999128993 0.268974985971886 no 939 0.268759523831753 1365 5036894 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.614944499791049 0.269523890108489 no 940 0.269295686799327 1367 23847180 SGTC_1973 st070275 50.2 µM 0.613633875089386 0.269967147525949 no 941 0.269728646647086 1282 17118334 SGTC_308 4092-1169 104 µM 0.613424501152046 0.270037992234781 no 942 0.269797844806243 1302 2268590 YDL196W YDL196W SGTC_2270 7924575 90.91 µM 0.612693070847724 0.270285555274839 no 943 0.270039652523491 1336 1262135 SGTC_3161 9100388 49.47 µM 0.612188662447836 0.27045634559079 no 944 0.270206470925858 1356 25236368 SGTC_895 0964-0006 13.7 µM 0.611704986203304 0.270620166730106 no 945 0.270366481158857 1299 6738897 SGTC_2640 pentamidine 10.38 µM 0.6111442475854 0.270810150908596 no 946 0.270552044503206 1337 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3046 9092212 49.47 µM 0.61066787519497 0.270971603203713 no 947 0.270709738785137 1343 25236637 SGTC_1295 1013-0063 9.78 µM 0.610624872971202 0.270986179895076 no 948 0.270723976135228 1340 6826038 SGTC_195 4234-0266 16.654 µM 0.609440661122635 0.271387752108674 no 949 0.271116196629587 1315 2303354 SGTC_1970 st070122 35.8 µM 0.608727161381184 0.271629846534599 no 950 0.271352650212645 1360 102928 SGTC_2646 retinol 96.75 µM 0.607566064597803 0.272024042849603 no 951 0.271737656867802 1331 445354 A vitamin A analog and teratogen. SGTC_2122 5258151 111.688 µM 0.605080257967831 0.272868938002654 no 952 0.27256283551213 1312 2173356 SGTC_1698 5-fluorocytosine 1.055 µM 0.604574798502074 0.27304089656541 no 953 0.272730777924881 1362 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1796 st049173 110.4 µM 0.602048053693947 0.273901306007646 no 954 0.273571075491736 1294 94134 SGTC_1673 st016611 27.3 µM 0.59989610354616 0.274635145394774 no 955 0.274287739683702 1409 5226799 SGTC_233 rapamycin 362 pM 0.599333147221865 0.274827279780733 no 956 0.274475373946467 1354 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_780 0109-0199 192 µM 0.597881055061522 0.275323177767654 no 957 0.27495965084345 1426 610414 SGTC_567 1080-0542 68.4 µM 0.59682673327668 0.275683510574917 no 958 0.275311533789543 1302 5950415 SGTC_2197 6588183 93.1375 µM 0.594959523535937 0.276322230269734 no 959 0.2759352637638 1318 884136 SGTC_2173 5763948 167 µM 0.593653068795437 0.276769562785092 no 960 0.276372089296425 1349 2867177 SGTC_2814 7977482 42.97 µM 0.592109492949627 0.277298542777228 no 961 0.276888635261203 1416 6456762 SGTC_1502 4534-4282 27.7 µM 0.59101478991726 0.277673994491155 no 962 0.277255255651143 1345 3278949 SGTC_925 2064-1272 59.6 µM 0.588312519066279 0.278601857447548 no 963 0.278161272053507 1340 6815817 SGTC_400 oxethazaine 37.5 µM 0.58664322446581 0.279175786871162 no 964 0.278721673102935 1343 4621 A local anesthetic. SGTC_2303 7774051 200 µM 0.585459375327396 0.279583160622671 no 965 0.279119437457446 1414 2953184 SGTC_298 1391-0729 10 µM 0.58524421748711 0.279657229460386 no 966 0.27919175849064 1328 3237558 SGTC_707 0865-0008 204 µM 0.584860644101734 0.279789299556273 no 967 0.279320711652076 1405 723043 SGTC_211 3455-0679 143.504 µM 0.584735125448135 0.279832524089822 no 968 0.279362915929013 1368 748649 SGTC_1946 st076057 65.1 µM 0.583828627506928 0.2801447885702 no 969 0.27966780790833 1274 953009 SGTC_1311 1190-0148 100 µM 0.582916413072842 0.280459192584927 no 970 0.279974785508939 1414 1961333 SGTC_3131 9127911 49.47 µM 0.582534889548902 0.280590739200771 no 971 0.280103223904958 1404 45595681 SGTC_626 0214-0009 33 µM 0.582358173564439 0.280651679738934 no 972 0.28016272432197 1445 3437874 SGTC_834 0312-0008 75.7 µM 0.580184591546896 0.281401763129786 no 973 0.28089507166322 1379 6385573 YIL048W NEO1 SGTC_2250 alverine citrate 130 µM 0.579837589785741 0.281521599775003 no 974 0.281012072944533 1311 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2934 9036370 36.88 µM 0.579151251535429 0.28175869834815 no 975 0.281243560275094 1405 6462800 SGTC_2018 5133068 143 µM 0.579051150515632 0.281793286727726 no 976 0.281277329917325 1372 785362 SGTC_2952 9073731 13.78 µM 0.577690005278103 0.28226381268022 no 977 0.281736714101958 1336 16457353 SGTC_1691 st019933 84.6 µM 0.577132020463738 0.282456808231335 no 978 0.281925137484739 1377 6176082 SGTC_939 1165-0479 45.3 µM 0.576566413591375 0.282652504840376 no 979 0.282116196662905 1310 1377347 SGTC_276 colchicine 750 µM 0.574317549977364 0.283431242206988 no 980 0.282876467622727 1405 2833 A microtubule depolymerizer. SGTC_2370 9071495 200 µM 0.573128517881285 0.283843395930343 no 981 0.283278839712896 1334 21791103 SGTC_2750 bromebric acid 70.15 µM 0.571786220914422 0.284309020275129 no 982 0.283733406694156 1431 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1033 k072-0102 21.3 µM 0.571354511675902 0.284458851821082 no 983 0.283879678623984 1385 5965931 SGTC_3045 9092950 49.47 µM 0.570669160456847 0.284696791291185 no 984 0.284111963755117 1488 44120432 SGTC_3136 9095672 49.47 µM 0.570482442816172 0.284761632176523 no 985 0.284175263457404 1263 17217380 SGTC_807 1315-0151 48 µM 0.568390917229961 0.285488431312268 no 986 0.284884778218693 1419 4011080 SGTC_2124 5246320 200 µM 0.568116080088605 0.285584002039815 no 987 0.284978074864286 1403 579342 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.567980272409934 0.285631232859 no 988 0.285024181729478 1441 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_9 0092-0002 10.449 µM 0.567802450709657 0.285693080817617 no 989 0.285084557781166 1382 759368 SGTC_3216 9129716 49.47 µM 0.567630369592979 0.285752938215937 no 990 0.285142990528752 1332 8056934 SGTC_2839 9003951 25.97 µM 0.566483042309696 0.286152181621213 no 991 0.285532728712768 1397 2990634 SGTC_3015 9080845 49.47 µM 0.566014922975652 0.286315152416748 no 992 0.285691818024911 1463 5296973 SGTC_2545 solidagenone 89.61 µM 0.565735012202743 0.286412621439293 no 993 0.285786965219508 1291 6708572 An anti ulcer agent SGTC_1874 staurosporine 7.6 µM 0.56569666714021 0.28642597497686 no 994 0.285800000636449 1442 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_81 0411-0046 9.971 µM 0.565266787813671 0.286575699209745 no 995 0.28594615760962 1298 12925265 SGTC_1132 3456-3614 2.5 µM 0.565067206565333 0.286645224704815 no 996 0.286014026381243 1555 3125502 SGTC_2079 5212404 121 µM 0.563818715222308 0.287080326642494 no 997 0.286438756804852 1439 758462 SGTC_2872 9044037 25.97 µM 0.562354629982134 0.287590961578564 no 998 0.28693721215768 1413 6465195 SGTC_1275 0867-0008 21.1 µM 0.561344438280176 0.287943540364433 no 999 0.287281376534879 1409 3422836 SGTC_1346 1488-2224 62.4 µM 0.56073999782261 0.288154600719364 no 1000 0.287487398015395 1411 3722427 SGTC_957 1187-1561 14.1 µM 0.55920677816715 0.288690302157263 no 1001 0.288010303879256 1371 1538454 SGTC_1394 3474-0001 65.7 µM 0.55914825835428 0.288710758058526 no 1002 0.288030271002769 1359 5017666 YIL048W NEO1 SGTC_3347 9188721 44.724 µM 0.558529119298235 0.288927223097594 no 1003 0.288241562991451 1402 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_347 4534-1311 26.2 µM 0.555810502685938 0.289878615791735 no 1004 0.289170202468196 1376 2862016 SGTC_2536 dehydroabietamide 32.04 µM 0.553069468332737 0.290839338646993 no 1005 0.290107921186844 1503 3983547 SGTC_1513 0337-0559 19 µM 0.551903022239244 0.291248624869497 no 1006 0.290507398821383 1332 775073 SGTC_2583 asiatic acid 100 µM 0.551880421092107 0.291256557884683 no 1007 0.290515141671824 1401 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_846 0335-0850 148 µM 0.549307411084387 0.292160344453973 no 1008 0.291397251126114 1387 6819598 SGTC_2050 5263056 171 µM 0.548020749394449 0.29261278169855 no 1009 0.291838827763004 1425 763468 YGL055W OLE1 SGTC_1439 4092-1168 46 µM 0.54791273728401 0.292650777506961 no 1010 0.291875911222892 1423 2886240 SGTC_1640 st009078 66.4 µM 0.547578560338526 0.292768346644509 no 1011 0.291990657045643 1466 690618 SGTC_720 r052-1644 49.9 µM 0.546825367453371 0.29303341311119 no 1012 0.292249356713725 1399 1422863 YOR257W CDC31 SGTC_986 1493-0483 84 µM 0.546100820201297 0.293288503509854 no 1013 0.292498318016759 1382 40079 SGTC_634 1611-4317 11.2 µM 0.545953412109678 0.29334041388008 no 1014 0.292548980898873 1457 2843522 SGTC_574 1315-0397 40 µM 0.545735356033998 0.293417211037201 no 1015 0.292623932356863 1400 6794277 SGTC_836 0330-0104 1.35 µM 0.545422550617507 0.293527394221357 no 1016 0.292731467164964 1425 46494820 SGTC_2431 5490079 200 µM 0.545322740010229 0.293562555734462 no 1017 0.292765783458391 1413 5722345 SGTC_2955 9076254 12.21 µM 0.545221722501427 0.293598144403371 no 1018 0.292800516603437 1399 16459619 SGTC_3117 9124945 49.47 µM 0.543994319927305 0.294030720261501 no 1019 0.293222690776568 1314 17592065 SGTC_3296 9122258 64.045 µM 0.542339645094749 0.294614346376944 no 1020 0.293792274619261 1447 4730474 SGTC_2334 9017922 200 µM 0.541406119583846 0.294943849037487 no 1021 0.294113845060554 1541 3163164 SGTC_3311 9131146 2.8755 µM 0.541308326714375 0.294978376408391 no 1022 0.294147541066421 1417 4900406 YPR165W RHO1 SGTC_2450 5739737 12.93 µM 0.540866467780978 0.295134405137697 no 1023 0.29429981245062 1411 2262825 SGTC_711 k292-0785 179 µM 0.539839653764573 0.295497139240491 no 1024 0.294653808877677 1400 4146315 SGTC_1437 4092-1038 11.6 µM 0.539800639575896 0.295510925502641 no 1025 0.294667262978636 1389 3977136 SGTC_1565 sinapyl alcohol 95.1 µM 0.539599077713471 0.295582155190184 no 1026 0.294736776399557 1366 5280507 A phenol propionate derived from cinnamic acid. SGTC_712 r015-0009 80.6 µM 0.538952344866785 0.29581075655759 no 1027 0.294959868703853 1461 6813872 YLR060W FRS1 SGTC_1613 st002381 52.1 µM 0.53771786475166 0.296247334909006 no 1028 0.295385921929026 1405 551167 SGTC_2665 lovastatin 100 µM 0.535726483683776 0.29695221617499 no 1029 0.296073798682149 1408 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_280 3448-3607 3.04 µM 0.535398357721277 0.297068435214296 no 1030 0.296187212754345 1422 626179 SGTC_1094 duloxetine 25.4 µM 0.53486406591051 0.297257720697709 no 1031 0.296371929011613 1422 60834 A selective serotonin reuptake inhibitor. SGTC_2388 9080168 200 µM 0.534490644788282 0.297390046656934 no 1032 0.296501060131618 1383 15943073 SGTC_445 e6 berbamine 66 µM 0.532322830913799 0.2981587667246 no 1033 0.297251211087155 1444 6610268 A calcium/calmodulin antagonist. SGTC_1854 st056233 32.9 µM 0.531284040409092 0.298527448692896 no 1034 0.297610981586583 1451 5393174 SGTC_867 0518-0118 155 µM 0.529713608562864 0.299085211348005 no 1035 0.298155255595755 1462 6848158 SGTC_231 b-estradiol 524 µM 0.529190074660505 0.299271257434506 no 1036 0.29833680060748 1382 450 A steroid. SGTC_3103 9120822 49.47 µM 0.52726831625691 0.299954634446352 no 1037 0.299003636645402 1498 17141819 SGTC_874 0599-0792 117 µM 0.526593573264571 0.300194740347142 no 1038 0.299237927944501 1522 765305 SGTC_1954 st077032 68.9 µM 0.524952532804089 0.300779063575887 no 1039 0.29980809447717 1359 698907 SGTC_2948 9070189 9.45 µM 0.524844468317201 0.300817559965415 no 1040 0.299845657885666 1476 6473636 YDL196W YDL196W SGTC_2221 6807166 181.081 µM 0.523617466230839 0.301254817274882 no 1041 0.30027231535547 1453 674925 SGTC_65 0798-0905 34.986 µM 0.523189833677659 0.30140727664363 no 1042 0.300421077707093 1651 3602145 SGTC_3141 9094609 49.47 µM 0.521440553170487 0.30203129064185 no 1043 0.301029953708651 1408 25236309 YDL196W YDL196W SGTC_1871 st057448 67.3 µM 0.519424344901552 0.302751243577561 no 1044 0.301732429056208 1529 691747 SGTC_2492 derrusnin 100 µM 0.518218527020157 0.30318218717083 no 1045 0.302152904860213 1391 1715307 Part of coumarin class of compounds. SGTC_647 0140-0236 81 µM 0.518011145262805 0.30325633034446 no 1046 0.30222524660221 1492 990837 SGTC_1602 st001878 87.6 µM 0.517064932186661 0.303594723476252 no 1047 0.302555416185579 1479 595405 YLR310C CDC25 SGTC_1108 betulinic acid 729.144 nM 0.516979624697107 0.303625240182579 no 1048 0.302585191143485 1448 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2293 7624732 200 µM 0.516750338262539 0.303707268685835 no 1049 0.302665225723268 1397 894453 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.515923991008114 0.304002981053604 no 1050 0.302953748635763 1437 2374 Ca(2+)-ATPase inhibitor. SGTC_3258 9138477 49.47 µM 0.515095026643369 0.304299758868325 no 1051 0.303243308942083 1500 4970355 SGTC_1797 st048695 56.8 µM 0.513953320881579 0.30470871240094 no 1052 0.303642313392005 1513 592262 YIL048W NEO1 SGTC_725 1497-0963 19 µM 0.513232821854494 0.304966917398413 no 1053 0.303894234656068 1585 3549977 SGTC_178 4092-0806 87.505 µM 0.512523153329099 0.305221336037009 no 1054 0.304142460137305 1452 2169044 SGTC_540 1187-0821 17.3 µM 0.511852534752585 0.305461841651932 no 1055 0.304377109844444 1441 847520 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.51149914694637 0.305588611798036 no 1056 0.304500792794266 1389 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1516 st013856 110 µM 0.50919963767096 0.306414079216518 no 1057 0.305306148518586 1458 5281404 A mutagen and neurotoxin. SGTC_1090 efavirenz 20.7 µM 0.508896034164953 0.306523139002643 no 1058 0.305412549968933 1485 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1207 2099-0101 141 µM 0.508648478737182 0.3066120780051 no 1059 0.305499320873788 1514 5837381 SGTC_2974 9094440 9.66 µM 0.50806957464579 0.306820104778287 no 1060 0.305702275781531 1572 25236134 SGTC_1209 2323-2347 50.3 µM 0.506839751554788 0.307262243040328 no 1061 0.306133630995074 1478 5412760 SGTC_54 0159-0055 9 µM 0.506252966294821 0.307473299203312 no 1062 0.306339538235022 1562 3319099 SGTC_1246 0422-0085 105 µM 0.505028344306546 0.307913979154405 no 1063 0.306769464053439 1515 264295 SGTC_1067 clotrimazole 1.36 µM 0.504946067267439 0.307943596471917 no 1064 0.306798358444812 1471 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1365 1672-3266 55.4 µM 0.503779494316238 0.308363663020364 no 1065 0.307208169472444 1518 6415873 SGTC_1463 k081-0032 34.1 µM 0.503145758176399 0.308591967779223 no 1066 0.307430898705211 1372 977755 SGTC_37 0566-0070 1.56 µM 0.501563606887301 0.309162263977104 no 1067 0.307987262312573 1569 1626686 SGTC_3274 9138298 49.47 µM 0.501115466621452 0.309323882591389 no 1068 0.30814493118217 1449 17015756 SGTC_277 nystatin 15.5 µM 0.500838968764835 0.309423617993437 no 1069 0.308242228891559 1451 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2817 7995342 71.43 µM 0.500624110934877 0.309501128946994 no 1070 0.308317845200091 1397 18879975 SGTC_2300 7976697 71.57 µM 0.500309325073745 0.309614704702365 no 1071 0.308428644515704 1411 2236109 SGTC_3291 9121177 71.43 µM 0.50027695372611 0.309626385420364 no 1072 0.308440039673989 1454 17015612 SGTC_1913 st060213 96.1 µM 0.499573235367327 0.309880359201803 no 1073 0.308687803782662 1553 688959 SGTC_2077 5212015 200 µM 0.497675294795083 0.310565783118581 no 1074 0.309356461932748 1384 780900 SGTC_3332 9141069 11.198 µM 0.496395963501723 0.31102817347241 no 1075 0.309807536200956 1434 17332883 SGTC_413 propylparaben 100 µM 0.495296627904619 0.311425746231031 no 1076 0.310195375442563 1444 7175 A pharmaceutical preservative. SGTC_1403 3909-7815 62.9 µM 0.495283516408909 0.311430489308622 no 1077 0.310200002377829 1525 6615483 SGTC_2543 pimpinellin 60.67 µM 0.494749826470529 0.311623577957853 no 1078 0.310388362511668 1435 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3308 9128332 17.569 µM 0.494084194940742 0.311864475587346 no 1079 0.310623359716905 1591 17332805 YDL196W YDL196W SGTC_1762 st045503 25.4615 µM 0.492666917851188 0.312377668157044 no 1080 0.311123978275413 1494 4645554 SGTC_2099 5377090 177.372 µM 0.492322054123661 0.312502597591418 no 1081 0.311245845898626 1472 2243829 SGTC_1817 st052116 64.4 µM 0.491267977157591 0.312884578317493 no 1082 0.311618462872469 1543 4361398 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.481424907240457 0.316461206624057 no 1083 0.315107269020209 1535 4213774 SGTC_1509 1326-1131 80 µM 0.481252801078033 0.316523898248844 no 1084 0.315168418993747 1512 768313 SGTC_447 ml7 120 µM 0.480952388403714 0.316633339609455 no 1085 0.315275168894356 1590 4216 Selective myosin light chain kinase inhibitor. SGTC_2541 muurolladie-3-one 83.07 µM 0.480598963665016 0.316762113998911 no 1086 0.315400776071701 1538 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3222 9128301 49.47 µM 0.480063269252796 0.316957342786595 no 1087 0.315591202580378 1508 4911358 SGTC_1206 3978-0017 132 µM 0.477842333866905 0.317767285031179 no 1088 0.316381213799262 1585 3873677 SGTC_2338 7999974 200 µM 0.477774413972775 0.317792068183212 no 1089 0.316405386889209 1607 315925 SGTC_1296 1068-0102 11.9 µM 0.475345473579109 0.318678895179897 no 1090 0.317270376050057 1564 767053 SGTC_3029 9088683 49.47 µM 0.475267277828074 0.318707462417798 no 1091 0.3172982395811 1509 25236615 SGTC_2908 7930301 100 µM 0.475181164480419 0.318738923436267 no 1092 0.317328925591419 1411 2223178 SGTC_21 0849-0113 22.993 µM 0.474459905557155 0.319002482533167 no 1093 0.317585991464993 1494 1560156 SGTC_642 0335-0876 158 µM 0.474287543276124 0.319065479916048 no 1094 0.317647436608262 1548 6812350 SGTC_1587 estradiol valerate 56.1 µM 0.474228741041837 0.319086972976696 no 1095 0.317668400068347 1563 13791 A steroid. SGTC_162 k030-0015 37.8 µM 0.472511768769702 0.319714818888962 no 1096 0.318280771727337 1665 1809920 YMR134W ERG29 SGTC_1452 4194-0072 190 µM 0.471951250295594 0.319919895915649 no 1097 0.318480792726999 1654 1343545 SGTC_1480 1070-0044 41.2 µM 0.471923723749527 0.319929968478116 no 1098 0.318490616937728 1561 3124987 SGTC_1646 st011709 75.6 µM 0.471406321417755 0.320119321948447 no 1099 0.31867530131288 1578 5757843 SGTC_318 1488-0629 67.2 µM 0.470930879256962 0.320293360593704 no 1100 0.318845047918582 1486 3662576 SGTC_1546 5-methoxyflavanone 78.7 µM 0.470116812217664 0.320591446831839 no 1101 0.319135781645662 1593 147795 SGTC_1214 0358-0031 63.7 µM 0.470090031300869 0.320601255144992 no 1102 0.319145348002308 1706 4301366 SGTC_969 1313-0238 134 µM 0.469710079567001 0.320740423156947 no 1103 0.319281082758542 1544 5212874 SGTC_281 1672-3440 14.9 µM 0.469656636022258 0.320760000380586 no 1104 0.319300176986662 1554 6833000 SGTC_79 0052-0007 94.094 µM 0.469603423018991 0.320779493648476 no 1105 0.319319189323452 1614 2801472 SGTC_218 alverine citrate 93.75 µM 0.468006239040535 0.321364812308446 no 1106 0.319890064021847 1578 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_209 4077-0173 175.592 µM 0.467924215384916 0.321394883443773 no 1107 0.319919392923326 1517 15993494 SGTC_1168 k815-0004 80.5 µM 0.465813739538997 0.3221690185074 no 1108 0.320674414797344 1502 642433 SGTC_1277 0873-0036 22 µM 0.464492400985033 0.322654086594762 no 1109 0.321147501312091 1631 5965735 SGTC_3232 9132874 49.47 µM 0.462645707352102 0.323332520222266 no 1110 0.321809170235328 1500 3784940 SGTC_808 0711-0032 135 µM 0.459087501948841 0.324641380919886 no 1111 0.323085665636774 1667 4252555 SGTC_1626 st003712 1.76 µM 0.457258839130279 0.325314886321422 no 1112 0.323742505538571 1582 24207035 SGTC_883 0850-0245 24.6 µM 0.457019147071518 0.325403208441814 no 1113 0.32382864162504 1617 6823229 YPR165W RHO1 SGTC_1983 st071813 46.9 µM 0.456498780289902 0.325594987791059 no 1114 0.324015673862459 1538 11838595 SGTC_171 k064-0041 9.68 µM 0.456456400215136 0.325610608852852 no 1115 0.324030908229855 1478 53325 SGTC_2035 5154463 94.595 µM 0.454908825176855 0.326181246074581 no 1116 0.3245874167937 1613 2769623 SGTC_639 0833-0042 114 µM 0.454306927846653 0.326403293690653 no 1117 0.324803965214924 1518 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2383 9036125 200 µM 0.453783582767404 0.326596412394043 no 1118 0.324992300529944 1578 79580 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.45235654796567 0.327123236175998 no 1119 0.325506072311713 1564 17037758 SGTC_1798 st045719 60.953 µM 0.452003551723315 0.327253606331228 no 1120 0.325633211883812 1520 3980186 SGTC_2305 7443522 69.23 µM 0.448727734262822 0.328464449488581 no 1121 0.326814037594242 1622 5415886 SGTC_1932 st074806 40.9 µM 0.448395083828304 0.328587508439783 no 1122 0.326934044583714 1630 17251235 SGTC_1202 1988-0068 29.6 µM 0.447868700897049 0.328782273756287 no 1123 0.327123979091173 1503 2850480 SGTC_1089 terbinafine 2.25 µM 0.447817575168599 0.328801193107441 no 1124 0.327142429150595 1611 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2327 6189656 200 µM 0.447556506805658 0.328897809700414 no 1125 0.327236649098579 1668 5349088 SGTC_462 ag-879 158 µM 0.447238439350159 0.329015536058928 no 1126 0.327351454978163 1637 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.446947368997786 0.329123284839484 no 1127 0.327456530613793 1616 5377381 SGTC_746 1095-0025 46.6 µM 0.445783727446186 0.329554184855718 no 1128 0.327876738668008 1652 6749286 SGTC_550 4123-0385 25.7 µM 0.445371096879427 0.329707037618212 no 1129 0.328025798014785 1526 5731123 SGTC_208 k072-0098 12.366 µM 0.444334198090894 0.330091266633369 no 1130 0.328400489917338 1564 5948901 SGTC_3329 9141233 27.5565 µM 0.443581851074535 0.330370165557378 no 1131 0.328672464811048 1637 4909101 YNL103W MET4 SGTC_2190 6049624 200 µM 0.442988723647533 0.330590107410614 no 1132 0.328886945518691 1590 2265554 SGTC_2964 9083345 53.42 µM 0.442504186388598 0.330769825592931 no 1133 0.329062200785296 1511 17741579 SGTC_1555 citronellol 128 µM 0.44221024218749 0.330878870523485 no 1134 0.329168537590941 1678 8842 A terpine precursor. SGTC_1179 1021-1431 9.29 µM 0.440797060026246 0.331403321082895 no 1135 0.329679961060868 1588 2840958 SGTC_2126 5251174 33.877 µM 0.44050964671936 0.331510024467565 no 1136 0.329784013505631 1747 790722 SGTC_455 paf C-16 10 µM 0.440500548676017 0.33151340237732 no 1137 0.32978730749192 1562 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1888 azatryptophan 97.5 µM 0.440211838865505 0.33162060129804 no 1138 0.329891842993639 1537 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_555 4296-0685 37 µM 0.438808947132898 0.332141695899505 no 1139 0.330399988388248 1606 2908540 YHR072W ERG7 SGTC_689 0833-0039 98 µM 0.437075806568578 0.332785907556132 no 1140 0.331028186134673 1667 5374726 SGTC_2957 9076800 11.52 µM 0.436978957965401 0.332821920957236 no 1141 0.331063304139861 1521 16459615 SGTC_2919 7978188 46.38 µM 0.436640350104497 0.332947845279118 no 1142 0.331186097483743 1695 2980291 SGTC_2285 7945142 200 µM 0.436215037620879 0.33310604073636 no 1143 0.331340359266773 1576 2970608 SGTC_2832 7992762 51.95 µM 0.436045794061271 0.333168999331717 no 1144 0.331401752244205 1417 2985177 SGTC_2179 6298986 200 µM 0.435797634435199 0.333261323200723 no 1145 0.331491780159021 1679 738374 SGTC_708 3448-5400 146 µM 0.434843996817747 0.333616202988588 no 1146 0.331837833550294 1562 3462195 SGTC_621 3584-0052 32.1 µM 0.434661002919485 0.333684318050931 no 1147 0.331904254293611 1656 2273927 SGTC_2354 9060492 162 µM 0.434545584060916 0.333727282754963 no 1148 0.33194615024576 1684 6471895 SGTC_3133 9127736 49.47 µM 0.431463157938401 0.334875521902427 no 1149 0.333065817718077 1691 27243420 SGTC_650 1328-0195 38 µM 0.430836582385079 0.335109117842197 no 1150 0.33329359896183 1630 2780821 SGTC_3092 9117248 49.47 µM 0.429981842778287 0.335427879315067 no 1151 0.33360442464972 1674 17141857 SGTC_2198 6589944 200 µM 0.42930533193814 0.335680257248987 no 1152 0.333850518536456 1623 5290268 SGTC_2220 6782180 200 µM 0.429095942087959 0.335758386885046 no 1153 0.333926702630262 1604 833803 SGTC_2159 5658611 73.75 µM 0.428394820725563 0.336020047973673 no 1154 0.334181847410228 1639 793844 SGTC_2664 lyso-paf C-16 73.48 µM 0.428334852851465 0.336042431898153 no 1155 0.334203673853681 1585 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1117 retinoic acid 1.10837 µM 0.428006714376273 0.336164924887317 no 1156 0.334323115991638 1699 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1732 st034308 51.822 µM 0.427709098175067 0.336276039060781 no 1157 0.334431462555137 1556 830119 SGTC_1642 st009582 77.7 µM 0.427616396823173 0.336310651772296 no 1158 0.334465213108385 1679 6739311 SGTC_2349 9023730 187.07 µM 0.425340522284768 0.337160849425512 no 1159 0.335294228749166 1683 4126287 SGTC_1997 st073024 93.8 µM 0.425087655019403 0.337255364417519 no 1160 0.335386388423409 1616 686268 SGTC_1926 methyl fluorone black 53.6 µM 0.423813572509824 0.337731738395604 no 1161 0.335850889486907 1500 72721 Reacts with homocysteine. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.422505541205696 0.338221076268434 no 1162 0.336328028493822 1671 16725076 SGTC_2586 curcumin 80 µM 0.422424342103701 0.33825146208229 no 1163 0.336357656715466 1692 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_76 0433-0009 400.328 µM 0.421070012026265 0.338758426100053 no 1164 0.336851979278912 1593 2841569 SGTC_62 0180-0423 3.232 µM 0.421024346895468 0.338775524946951 no 1165 0.336868651703084 1589 30102 YGL099W LSG1 SGTC_2935 9038016 29.96 µM 0.42068007516242 0.338904444711827 no 1166 0.336994356268915 1614 6463195 SGTC_987 1497-1013 404 µM 0.420543332366778 0.338955656154252 no 1167 0.337044290468014 1629 1676435 SGTC_1028 k015-0029 4.8 µM 0.420282422070313 0.339053377731428 no 1168 0.337139574727343 1570 4588309 SGTC_1661 st013063 9.66 µM 0.419221764000658 0.339450748998905 no 1169 0.33752703384224 1606 721395 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.417004666337907 0.340281952047335 no 1170 0.338337497278708 1686 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3181 9108277 49.47 µM 0.41697789587433 0.340291993206041 no 1171 0.338347287849681 1550 17097298 SGTC_1096 rimcazole 32.2 µM 0.416155710422743 0.340600436505123 no 1172 0.338648033073127 1601 18528119 A dopamine reuptake inhibitor. SGTC_3140 9094243 49.47 µM 0.415824047465945 0.340724890229554 no 1173 0.338769380403946 1598 19291112 SGTC_1763 st044482 94.5 µM 0.41516714409471 0.340971438846381 no 1174 0.33900977460704 1658 88505 SGTC_2805 7950783 58.44 µM 0.414967850151153 0.341046251176285 no 1175 0.339082719319455 1641 1178958 YDL195W SEC31 SGTC_1362 1611-0397 101 µM 0.414928927044871 0.341060863128968 no 1176 0.339096966491731 1595 27816 SGTC_261 5-fluorouridine 15.376 µM 0.413480943603303 0.341604613461829 no 1177 0.33962714071077 1673 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2343 7990716 14.84 µM 0.413430220462747 0.341623667109736 no 1178 0.339645718577943 1643 6456862 SGTC_1570 verbenone 133 µM 0.412640323302383 0.341920436243028 no 1179 0.339935076711551 1722 29025 A natural terpanoid with antifungal properties. SGTC_1712 st032288 53.4 µM 0.41138823150656 0.342391054814607 no 1180 0.34039394095412 1587 2883011 SGTC_1130 3454-2858 15.9 µM 0.41020684961372 0.342835320460752 no 1181 0.340827108344725 1557 715628 YIL048W NEO1 SGTC_369 0957-0393 4.5 µM 0.408650881822146 0.343420783043343 no 1182 0.341397942310736 1558 6997992 SGTC_1846 st056244 14.8 µM 0.408607511890961 0.34343710719899 no 1183 0.34141385853412 1653 5393182 SGTC_591 4299-0174 154 µM 0.407698238110833 0.343779419050219 no 1184 0.341747615569902 1638 5509088 SGTC_3234 9132280 49.47 µM 0.407561794150242 0.343830796802148 no 1185 0.341797709224049 1614 17612295 SGTC_2359 9039622 200 µM 0.406987133880755 0.344047215837997 no 1186 0.342008718953026 1681 6463596 SGTC_185 k048-0037 25.491 µM 0.406328753096982 0.344295227110351 no 1187 0.342250530713189 1724 6827589 SGTC_454 lyso-paf C-16 6.67 µM 0.406091671427329 0.344384551904814 no 1188 0.342337622516783 1519 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2482 5981709 142.65 µM 0.405278585169224 0.344690962722509 no 1189 0.342636372914517 1644 877755 SGTC_3084 9116877 49.47 µM 0.404812940718825 0.344866486319747 no 1190 0.342807507925883 1710 27241325 SGTC_1049 3226-0134 66 µM 0.404672603493742 0.344919392661969 no 1191 0.342859091401805 1612 5702385 SGTC_84 0443-0269 128.823 µM 0.404496130217197 0.344985926395608 no 1192 0.342923961492673 1607 6150058 SGTC_2148 5546263 113.568 µM 0.404155688681916 0.345114292777269 no 1193 0.343049118017244 1630 792097 SGTC_387 norethindrone acetate 66.7 µM 0.403844075082075 0.345231804965094 no 1194 0.343163691623902 1606 541197 SGTC_1045 1348-1485 165 µM 0.402450192968361 0.345757632521755 no 1195 0.343676368417163 1584 6810614 SGTC_1109 tnp00067 928.257 nM 0.39956049964067 0.346848686631744 no 1196 0.344740127471346 1615 676295 SGTC_701 4424-0219 185 µM 0.399012254335881 0.347055829947153 no 1197 0.344942087434209 1730 2911779 SGTC_2222 6885208 172.143 µM 0.398873026645388 0.347108441572898 no 1198 0.344993382496966 1646 609514 SGTC_618 k072-0232 33.2 µM 0.39829761410794 0.347325910810868 no 1199 0.345205409484522 1645 5872756 YGL099W LSG1 SGTC_832 4083-0019 164 µM 0.397244805431101 0.347723935436149 no 1200 0.345593472315674 1771 1990758 SGTC_1686 st019653 115.5 µM 0.39600567406338 0.348192616260663 no 1201 0.346050421196142 1737 97252 SGTC_2909 7941780 10.49 µM 0.395933223274448 0.348220026750175 no 1202 0.346077145492365 1771 1243215 SGTC_3315 9136395 68.55 µM 0.393550244123438 0.349122026402491 no 1203 0.346956560987667 1761 16876844 SGTC_2598 perillyl alcohol 100 µM 0.393018907282374 0.349323263257853 no 1204 0.347152758378889 1693 10819 An apoptosis inducer. SGTC_2325 6158266 200 µM 0.392923100175783 0.349359553451914 no 1205 0.347188139742341 1613 3623240 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.392170899928974 0.349644522658301 no 1206 0.34746597197375 1647 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_132 0417-1715 25.805 µM 0.391917528029904 0.349740531064522 no 1207 0.347559575728531 1798 6769098 SGTC_785 1270-0111 65.3 µM 0.39009205716091 0.35043252741638 no 1208 0.348234237994136 1617 6741994 SGTC_27 0485-0001 32.618 µM 0.388156690458399 0.35116672538007 no 1209 0.348950040674619 1690 2054479 SGTC_1287 0971-0001 34.6 µM 0.387912909416517 0.351259245283788 no 1210 0.349040242206925 1677 4665869 SGTC_590 k048-0076 22.4 µM 0.38593017665598 0.35201206000907 no 1211 0.349774190471196 1730 6832814 SGTC_2272 7805186 180 µM 0.384641875869001 0.35250152033626 no 1212 0.350251382104201 1720 2956062 YPR165W RHO1 SGTC_1013 4112-3890 241 µM 0.383611158450299 0.352893293759608 no 1213 0.350633334201211 1614 705171 SGTC_2397 5161689 200 µM 0.381826149896281 0.353572140467802 no 1214 0.351295160448875 1720 2259942 SGTC_1043 0916-0009 19.3 µM 0.381374898344448 0.353743827319006 no 1215 0.351462542164788 1836 3101130 SGTC_2014 4013930 200 µM 0.380468943863926 0.354088603953795 no 1216 0.351798672754765 1681 64556 SGTC_2168 5727979 200 µM 0.380295861080144 0.354154487221158 no 1217 0.351862903762376 1582 695210 SGTC_2847 9005661 71.43 µM 0.379136073025257 0.354596068450061 no 1218 0.35229341002329 1661 2991449 SGTC_568 1193-0097 7.48 µM 0.37717724375341 0.355342322713748 no 1219 0.353020945209733 1676 3646150 SGTC_1608 st001473 40.5 µM 0.376869741515955 0.355459522171719 no 1220 0.353135204514648 1605 7292267 SGTC_3111 9122088 49.47 µM 0.375074214882695 0.356144130450367 no 1221 0.35380263652915 1752 16876704 SGTC_2601 securinine 100 µM 0.371898945887018 0.357355949207751 no 1222 0.354984044997866 1624 442872 A GABA receptor antagonist. SGTC_2299 7976368 114.88 µM 0.371247499647703 0.357604747429145 no 1223 0.355226598665678 1778 2979718 SGTC_327 1273-0057 3.96 µM 0.370920030246084 0.357729836339512 no 1224 0.35534854785819 1685 3108138 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.37041245621039 0.357923752995404 no 1225 0.355537597060151 1681 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1719 st032227 49.2 µM 0.369031320784949 0.358451595836426 no 1226 0.356052189635985 1609 3125804 SGTC_1376 2910-0861 41.3 µM 0.367364502695792 0.359088981223377 no 1227 0.356673573026669 1707 1112859 SGTC_2448 5185112 27.17 µM 0.364039359559689 0.360361675152893 no 1228 0.357914309133634 1667 5718189 SGTC_1744 st037937 38.9 µM 0.361450170794503 0.361353756986161 no 1229 0.358881474247499 1736 1016152 SGTC_2534 helenine 20.12 µM 0.361319829584675 0.361403723662345 no 1230 0.358930185867724 1672 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2306 7482397 179.52 µM 0.358888053445774 0.362336384677356 no 1231 0.359839418532888 1803 891448 SGTC_360 0957-0399 1.01 µM 0.358820847887847 0.36236217171465 no 1232 0.359864557752466 1777 6752301 YPR165W RHO1 SGTC_1142 3253-1408 9.78 µM 0.358760343606087 0.362385387980119 no 1233 0.359887190780486 1781 256655 SGTC_1813 st051246 8.6015 µM 0.35716788904195 0.362996614856507 no 1234 0.36048306170635 1806 5291959 SGTC_417 st075190 100 µM 0.356116662774997 0.36340029518405 no 1235 0.360876599538186 1812 222757 SGTC_3342 9147791 14.508 µM 0.354302877432753 0.364097161615173 no 1236 0.361555955779875 1698 1838168 SGTC_771 0250-0039 27.3 µM 0.353494375907014 0.364407937422629 no 1237 0.361858922174379 1703 3005115 SGTC_1831 st055328 12 µM 0.353242476584586 0.364504781953163 no 1238 0.361953333055786 1804 1103068 SGTC_979 1426-2828 121 µM 0.353176745114031 0.364530054319284 no 1239 0.361977970336372 1775 747872 SGTC_2086 5274770 176.623 µM 0.352392599183347 0.364831587299006 no 1240 0.362271925741036 1684 689278 SGTC_1348 1493-0373 93.8 µM 0.351904936897347 0.365019153589188 no 1241 0.362454778312932 1730 3010129 SGTC_2681 menadione 3.18 µM 0.351134979026829 0.365315363094352 no 1242 0.362743543571643 1710 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2938 9059746 27.26 µM 0.349695263119779 0.365869449857332 no 1243 0.363283704493623 1729 6471769 SGTC_2022 5136654 200 µM 0.348677637434856 0.366261260568861 no 1244 0.363665667313359 1714 1713771 SGTC_1645 Cervolide 78 µM 0.348619586090586 0.366283615961197 no 1245 0.363687460805605 1696 23173 A fragrance. SGTC_1782 st039423 80.636 µM 0.347898930963235 0.366561175775513 no 1246 0.363958044075971 1648 2068169 SGTC_1861 st057647 17.4 µM 0.346436361262842 0.367124697914823 no 1247 0.364507401314456 1841 688668 SGTC_557 1315-0110 16.2 µM 0.345409334642798 0.367520578314275 no 1248 0.364893330250703 1656 6833801 SGTC_614 0462-0418 107 µM 0.345094163818644 0.36764209315317 no 1249 0.365011790430509 1666 5188303 SGTC_424 splitomicin 100 mM 0.344291487495089 0.367951626687787 no 1250 0.365313542711695 1630 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2877 9040724 71.43 µM 0.343933786002612 0.368089593622134 no 1251 0.365448041276366 1836 6463895 SGTC_1447 4239-0816 81.9 µM 0.343828689325894 0.368130133076859 no 1252 0.365487561596397 1653 1341554 SGTC_3044 9093193 49.47 µM 0.340308485794803 0.369488844150645 no 1253 0.3668121136915 1653 25236277 SGTC_871 0574-0004 149 µM 0.339677493980468 0.369732564235281 no 1254 0.367049706121204 1722 9551173 SGTC_2474 5321570 43.32 µM 0.33949975265445 0.369801226133152 no 1255 0.367116641691397 1808 2841384 SGTC_1465 k213-0056 144 µM 0.339490749641756 0.36980470412889 no 1256 0.367120032241631 1702 24048857 YMR208W ERG12 SGTC_990 3985-0011 41.3 µM 0.33629519163206 0.371039865833122 no 1257 0.368324137760845 1719 5399565 YGL099W LSG1 SGTC_3212 9128307 49.47 µM 0.335996765570394 0.37115528292451 no 1258 0.368436652767651 1562 27243542 SGTC_638 3970-0837 4.09 µM 0.3356301403715 0.371297092082086 no 1259 0.368574896208345 1684 4118451 YLR208W SEC13 SGTC_519 k048-0011 62.8 µM 0.33437013554679 0.371784590014217 no 1260 0.369050136090169 1763 6836379 SGTC_1996 st072960 66.8 µM 0.333769329507082 0.372017115317177 no 1261 0.369276814499383 1845 1719405 SGTC_1664 st014217 9.02 µM 0.333509886531494 0.372117539957363 no 1262 0.369374713926861 1778 3982782 SGTC_2424 5537928 59.2 µM 0.333276181339596 0.372208009518047 no 1263 0.369462908591063 1682 5382802 SGTC_2883 9059145 45.46 µM 0.332039121795263 0.372687004722469 no 1264 0.369929859139858 1689 16476510 SGTC_3244 9134489 49.47 µM 0.33171519923258 0.372812461610795 no 1265 0.370052161301962 1695 16584271 SGTC_1353 1498-1206 8.11 µM 0.331656144837096 0.372835335138862 no 1266 0.370074459653434 1717 6756808 SGTC_2644 guaiazulene 100 µM 0.330652249307551 0.373224242342754 no 1267 0.370453587365279 1812 3515 A coloring agent. SGTC_1332 1480-0653 17.5 µM 0.328905217849982 0.373901346827577 no 1268 0.371113665136649 1855 5749438 SGTC_3073 9114972 49.47 µM 0.328762872718346 0.373956533321662 no 1269 0.371167463882983 1859 41905075 SGTC_3137 9097352 49.47 µM 0.328683742903688 0.373987212671618 no 1270 0.371197371753908 1800 44120435 SGTC_1391 3442-0225 151 µM 0.327901339231933 0.374290600640087 no 1271 0.371493130554543 1742 5227075 SGTC_884 0851-0618 334 µM 0.327490128578984 0.374450084550604 no 1272 0.371648603982278 1848 9642473 SGTC_3139 9095020 49.47 µM 0.326099498647671 0.374989585389381 no 1273 0.372174538167197 1683 25236292 SGTC_2227 7312221 64.1025 µM 0.32458745917545 0.375576465241262 no 1274 0.372746659937774 1802 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2944 9067346 25.62 µM 0.323768148203324 0.375894591303078 no 1275 0.373056786204539 1772 6473075 SGTC_483 fpl-64176 144 µM 0.322868209467419 0.376244121133937 no 1276 0.373397526572834 1766 3423 SGTC_2626 ethyl orsellinate 100 µM 0.322496643723543 0.376388464265503 no 1277 0.373538239987885 1709 75653 A natural product. SGTC_1257 0669-0121 16 µM 0.320295792086781 0.377243788794198 no 1278 0.374372056353863 1852 4307855 SGTC_2033 5192550 145 µM 0.320167295745442 0.377293745426303 no 1279 0.374420756779848 1715 182073 SGTC_2314 7727897 200 µM 0.320012399972642 0.377353968322932 no 1280 0.37447946531785 1673 900724 SGTC_2880 9042983 58.44 µM 0.319917660968968 0.377390803963012 no 1281 0.374515374694059 1738 6464714 SGTC_1715 st032160 10.2275 µM 0.319524298129286 0.377543759993769 no 1282 0.374664484524392 1837 5289825 SGTC_1182 1222-0449 220 µM 0.317609978323703 0.378288401894804 no 1283 0.375390402091487 1769 658318 SGTC_3202 9113761 49.47 µM 0.31668281028495 0.378649219205611 no 1284 0.375742146689208 1899 4798415 SGTC_1497 4476-2978 41.3 µM 0.316544375157653 0.378703101794754 no 1285 0.375794674418306 1781 1528379 SGTC_753 1322-0200 289 µM 0.313917542054144 0.379725980013306 no 1286 0.376791833368446 1770 5403907 SGTC_1363 1636-0063 10.4 µM 0.313187041050605 0.380010584131234 no 1287 0.37706928164692 1759 6072185 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.313172968626883 0.380016067403924 no 1288 0.377074627054132 1742 442882 SGTC_1356 1502-0781 85.8 µM 0.312915189938536 0.380116514271342 no 1289 0.377172548402249 1761 567702 SGTC_2791 5663188 71.43 µM 0.310946652314972 0.380883847140673 no 1290 0.377920588882337 1858 54690634 SGTC_1426 4048-4480 71.7 µM 0.31041296494908 0.38109195852455 no 1291 0.378123468075578 1837 14224343 SGTC_1898 st060199 18.6 µM 0.309213790450791 0.381559702003454 no 1292 0.378579452170381 1736 688866 SGTC_3108 9121785 49.47 µM 0.308782554742329 0.381727949789712 no 1293 0.37874347019901 1884 17140271 SGTC_2623 humulene 100 µM 0.30771803809205 0.382143369463064 no 1294 0.37914844645049 1720 6187145 An anti-inflammatory. SGTC_2119 5528445 120.635 µM 0.306836904091826 0.382487328109561 no 1295 0.379483758446537 1858 791935 SGTC_3095 9117207 49.47 µM 0.306266571610152 0.382710012018262 no 1296 0.379700844527747 1902 17015229 SGTC_1628 st004252 77.7 µM 0.305869496228591 0.382865071327694 no 1297 0.379852006024588 1869 692968 SGTC_147 4466-0538 29.23 µM 0.304481269657525 0.383407326014211 no 1298 0.38038063020754 1789 6742687 YHR072W ERG7 SGTC_2461 5755302 26.15 µM 0.303981996828084 0.383602402713234 no 1299 0.380570803498232 1887 2788904 SGTC_49 0717-0965 32.132 µM 0.303975431254426 0.383604968221616 no 1300 0.380573304521168 1851 5889349 YGL099W LSG1 SGTC_862 0452-0056 10.2 µM 0.303452647981135 0.383809262989766 no 1301 0.38077246428467 1841 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3080 9117754 49.47 µM 0.303411473660379 0.383825354583365 no 1302 0.380788151416355 1882 9550191 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.300004528074727 0.385157535872682 no 1303 0.382086850859692 1754 2724 A muscle relaxant with antifungal properties. SGTC_1876 myriocin 605 nM 0.297809370183212 0.386016604493767 no 1304 0.382924331256903 1902 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2057 5236571 38.335 µM 0.297645818499917 0.386080632402774 no 1305 0.382986750252879 1896 54684039 YBR257W POP4 SGTC_3243 9134147 49.47 µM 0.297471765839455 0.386148774687177 no 1306 0.38305318025197 1862 24282180 SGTC_1026 k007-1105 30.6 µM 0.29680031332141 0.386411683816332 no 1307 0.383309483124205 1771 7066794 SGTC_2556 citropten 84.59 µM 0.29647705557947 0.386538274903938 no 1308 0.383432893374788 1692 2775 A potential DNA crosslinker. SGTC_1923 st058458 19.1 µM 0.295887924778931 0.386769015691001 no 1309 0.38365783651297 1904 3534982 SGTC_1751 st044839 27.194 µM 0.295260000307378 0.387014994598189 no 1310 0.383897635102123 1865 5291326 SGTC_152 4469-0003 551.229 µM 0.294582657521704 0.387280383183524 no 1311 0.384156355938708 1926 697280 SGTC_1243 0416-0003 5.65 µM 0.294557231146222 0.387290346477581 no 1312 0.384166068915264 1766 2141977 SGTC_129 0088-0017 176.636 µM 0.293520205455819 0.387696766917982 no 1313 0.384562278776552 1902 182446 SGTC_3302 9125395 16.351 µM 0.292587499948319 0.388062408409874 no 1314 0.384918734724476 1800 17599668 SGTC_2154 5570129 200 µM 0.292568204050459 0.388069973883927 no 1315 0.38492611014628 1853 673366 SGTC_2863 9028737 58.44 µM 0.292239300510589 0.388198935865023 no 1316 0.385051832508513 1920 6460917 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.291813697282959 0.388365831767739 no 1317 0.385214535962565 1878 140250 A respiratory chain inhibitor. SGTC_3087 9117406 49.47 µM 0.291490033910235 0.388492766812042 no 1318 0.385338282455368 1794 42546093 SGTC_149 3970-0822 46.1 µM 0.291388779315011 0.388532479517785 no 1319 0.38537699760909 1767 3114250 YBL034C STU1 SGTC_2490 carminic acid 95.39 µM 0.291182786734296 0.38861327473334 no 1320 0.385455763331992 1810 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2695 st077686 51.995 µM 0.289598083573245 0.38923499409419 no 1321 0.386061866646331 1743 2876092 SGTC_750 4073-0104 132 µM 0.288868177271964 0.389521450421132 no 1322 0.386341128452749 1833 22330957 SGTC_1799 st045822 46.1415 µM 0.28799906369511 0.389862617813935 no 1323 0.386673727690939 1907 3674992 SGTC_85 0868-0259 160.055 µM 0.287088562499872 0.390220122795414 no 1324 0.387022254768551 1823 83173 SGTC_1151 3909-8316 15.3 µM 0.286707533495074 0.390369760026738 no 1325 0.387168134382063 1800 800431 SGTC_1955 wogonin 32.4 µM 0.286584693838067 0.390418004925473 no 1326 0.387215167800158 1889 5281703 A flavanone. SGTC_1321 1326-2144 215 µM 0.285002302963548 0.391039634714368 no 1327 0.387821188778449 1920 3513030 SGTC_534 k292-0788 63.4 µM 0.284828062815344 0.391108100632902 no 1328 0.38788793566446 1972 4146317 SGTC_1681 tripelennamine 100 µM 0.283086935340957 0.391792444230983 no 1329 0.388555098118924 1791 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3178 9107506 49.47 µM 0.282270478317115 0.392113465080049 no 1330 0.388868060217378 1841 8897194 SGTC_1815 st051655 58.2 µM 0.282029696098384 0.392208151717826 no 1331 0.388960369988352 1935 5984156 SGTC_2369 9071472 200 µM 0.281610783304148 0.392372902696425 no 1332 0.389120985423516 1842 17296037 SGTC_2961 9083290 32.55 µM 0.281096515908852 0.392575181326033 no 1333 0.389318186691694 1817 17741490 SGTC_97 0535-0701 19.132 µM 0.280092959869208 0.39296999713472 no 1334 0.389703092917597 1743 2832013 YGL099W LSG1 SGTC_1504 k297-0033 30 µM 0.279309600171531 0.393278260560118 no 1335 0.390003619741647 1748 4388117 SGTC_543 3844-1095 191 µM 0.278807836034732 0.393475747212977 no 1336 0.390196150271023 1880 4230703 SGTC_1961 st076550 68.7 µM 0.277356200302432 0.394047242906299 no 1337 0.390753304933672 1827 1579337 SGTC_110 0850-0284 111.64 µM 0.277122440080523 0.39413929353132 no 1338 0.390843045825792 1891 3906265 SGTC_2854 9024559 71.43 µM 0.276878493069547 0.394235361838692 no 1339 0.39093670364027 1754 3163529 SGTC_3019 9081971 49.47 µM 0.274918478182366 0.395007464635989 no 1340 0.391689435207198 1939 16451803 SGTC_1511 0906-3109 28.5 µM 0.274392040027087 0.395214913238407 no 1341 0.391891679747598 1804 2882180 SGTC_3077 9117319 49.47 µM 0.273912715434333 0.395403822071276 no 1342 0.392075849833294 1859 17154678 SGTC_2470 5664817 21.68 µM 0.272416137540055 0.395993803307374 no 1343 0.392651032893322 1844 2859561 SGTC_970 1315-0089 19.5 µM 0.271270454298167 0.396445615922574 no 1344 0.393091514409374 1783 6811083 YLR033W RSC58 SGTC_1590 st077108 57.8 µM 0.271115785690808 0.396506621835661 no 1345 0.39315099044226 1946 5489485 SGTC_2706 st078239 82.5 µM 0.271065013998052 0.396526648258445 no 1346 0.393170514656172 1853 15434492 SGTC_293 4049-0273 38.5 µM 0.269946590413462 0.396967869205302 no 1347 0.393600671623781 1860 1380311 SGTC_2465 5809242 33.21 µM 0.269373859099103 0.397193864274568 no 1348 0.393821000171726 1876 2731748 SGTC_683 panaxydol 45 µM 0.268520464936336 0.397530670619554 no 1349 0.394149362179307 1923 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2752 diclazuril 33.15 µM 0.268478739117972 0.397547140376094 no 1350 0.394165419029008 1947 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3285 9112818 20.8695 µM 0.266182983694811 0.398453587421193 no 1351 0.395049143736177 1846 17017947 YPR165W RHO1 SGTC_2010 4012422 159 µM 0.264810081826222 0.39899592084255 no 1352 0.395577884953678 1867 952393 SGTC_837 0091-0265 12.5 µM 0.263162236626897 0.399647121796151 no 1353 0.39621276799118 1823 759367 SGTC_2630 antimycin a 100 µM 0.263101365813418 0.399671182286183 no 1354 0.396236225627883 1796 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3271 9137798 49.47 µM 0.261803431437773 0.400184309119996 no 1355 0.396736496706427 1956 6498326 SGTC_922 1866-0035 480 µM 0.260467913975614 0.400712474016458 no 1356 0.397251431143344 1844 3156169 SGTC_999 SEC7.066 22.7 µM 0.260001461491893 0.400896987537915 no 1357 0.397431323125229 1881 740511 YDR170C SEC7 SGTC_1058 3448-5425 97.3 µM 0.259572607618615 0.401066647774709 no 1358 0.397596734085753 1940 7279705 SGTC_1616 st002734 56.1 µM 0.25889558620573 0.401334524324248 no 1359 0.397857901906476 1887 4026101 SGTC_1662 st014054 52 µM 0.25735226629237 0.401945341730153 no 1360 0.39845342404022 1936 2838777 SGTC_909 3448-9333 149 µM 0.257200460599845 0.402005436574391 no 1361 0.398512014229652 1778 3344074 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.256150328677388 0.402421212383379 no 1362 0.398917380638158 1813 4174840 SGTC_599 1935-0052 86.5 µM 0.254800343690682 0.402955870325841 no 1363 0.399438654902605 1858 9557311 SGTC_1265 0819-1001 68.8 µM 0.253532770718917 0.403458054459009 no 1364 0.399928270402996 1873 3106768 SGTC_1694 st024011 44.9 µM 0.252670300317049 0.403799837071802 no 1365 0.400261500114264 1883 2787533 SGTC_2728 chlorpromazine 9.18 µM 0.252607736655524 0.403824632866768 no 1366 0.400285675448152 1892 2726 A thorazine and dopamine antagonist. SGTC_1461 k072-0203 53.8 µM 0.25195713920672 0.404082506408934 no 1367 0.400537096574839 1903 5418714 SGTC_2994 9053520 71.4286 µM 0.250485435278213 0.404665990813286 no 1368 0.401105983368798 1961 4647384 SGTC_161 4065-0411 162.148 µM 0.250195567636472 0.40478093927081 no 1369 0.401218056396423 1873 1906281 YLR208W SEC13 SGTC_78 0336-0123 156.75 µM 0.248274123728954 0.405543104745763 no 1370 0.401961159302512 1788 6765896 SGTC_1143 3454-2408 5.08 µM 0.246665759839946 0.406181358596233 no 1371 0.402583453771076 1888 X1143 SGTC_3004 9076122 71.4286 µM 0.246308795644219 0.406323048087467 no 1372 0.40272160085698 1950 44782551 SGTC_903 1134-0042 114 µM 0.245877967185505 0.406494072793933 no 1373 0.402888349990182 1850 701009 SGTC_3351 9150312 21.596 µM 0.245481017127875 0.406651664681866 no 1374 0.403042002362398 1961 4904905 SGTC_541 4513-1321 94 µM 0.245069188832596 0.406815179311456 no 1375 0.403201429663448 1820 747515 SGTC_507 nimesulide 162 µM 0.244963075346926 0.406857313841889 no 1376 0.403242511009651 1990 4495 A COX2 inhibitor. SGTC_740 k014-0057 261 µM 0.244414850382993 0.407075014943258 no 1377 0.403454770774733 1975 4012779 SGTC_1943 st076331 65.2 µM 0.24351906621311 0.407430794177294 no 1378 0.403801658440969 2018 24208415 SGTC_2774 tamoxifen 10.92 µM 0.242337343901242 0.407900256457512 no 1379 0.404259389862057 1909 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2259 7964009 200 µM 0.241590943527705 0.408196846788421 no 1380 0.404548570133858 1933 313134 SGTC_1829 berberine 14.4 µM 0.240921515208872 0.408462896185521 no 1381 0.404807973243021 1978 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1486 3970-0793 4.53 µM 0.240280862054346 0.408717549049611 no 1382 0.405056265173917 1988 2844330 SGTC_1703 st026983 48.3 µM 0.238553958455648 0.409404166675392 no 1383 0.405725735109259 2000 1104023 SGTC_2248 tofa 1.1 µM 0.238227601381404 0.409533957687771 no 1384 0.405852285235221 1881 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_721 1187-1332 279 µM 0.237162032688223 0.40995779942051 no 1385 0.406265544819537 1859 25730 SGTC_510 ag-490 170 µM 0.2362217139749 0.410331909006247 no 1386 0.406630315464128 2029 5328779 SGTC_2520 obtusaquinone 4.71 µM 0.235719354169328 0.410531808347055 no 1387 0.406825225289478 1982 5967872 SGTC_4 0960-0234 25.671 µM 0.231780108445024 0.412100117378597 no 1388 0.408354403771831 1873 6821112 SGTC_93 0109-0045 59.227 µM 0.231565994629383 0.412185401749019 no 1389 0.408437560987933 2017 88733 SGTC_2417 cerulenin 830 nM 0.230555713222046 0.412587866107618 no 1390 0.40882998819471 1973 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_142 0335-0849 62.6745 µM 0.229320952517889 0.413079880749878 no 1391 0.409309734798932 1915 3889043 YPR107C YTH1 SGTC_2739 tacrine 100.86 µM 0.229214308967063 0.413122381383557 no 1392 0.409351175835682 1918 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2488 5268135 45.7 µM 0.229139290332098 0.413152279155714 no 1393 0.409380328228992 1955 1270356 YLR208W SEC13 SGTC_2066 5222451 176 µM 0.228704309386965 0.413325645486941 no 1394 0.409549372576186 1935 2281147 SGTC_3175 9106517 49.47 µM 0.228137986027564 0.413551385070844 no 1395 0.409769485029063 1884 41468073 SGTC_1087 pterostilbene 9.05 µM 0.227791280405755 0.413689597932267 no 1396 0.409904252868856 2003 5281727 Similar to reservatol, lowers cholesterol. SGTC_525 k781-2675 26.7 µM 0.225765458203549 0.414497397411226 no 1397 0.410691921917899 2021 3651118 YDL195W SEC31 SGTC_938 3126-1755 342 µM 0.225695882041341 0.414525147449771 no 1398 0.410718980556485 2034 1777771 SGTC_2426 5582046 32.21 µM 0.225054531082446 0.414780966539854 no 1399 0.410968426263293 1949 2251934 SGTC_2452 5863136 48.41 µM 0.224764926659332 0.414896494458374 no 1400 0.411081076211148 1890 2184096 SGTC_2231 micatex 6.853 µM 0.22432286403823 0.415072854622858 no 1401 0.41125304328499 1955 20737 An antifungal of unknown mechanism. SGTC_609 0986-0026 86.3 µM 0.223900619776821 0.415241324266889 no 1402 0.411417316730236 1935 2848610 SGTC_312 4092-0653 6.84 µM 0.221902324733601 0.416038827364451 no 1403 0.412194960385888 2000 1148278 SGTC_137 0438-0332 85.389 µM 0.221344897582339 0.416261353785277 no 1404 0.412411946804901 1982 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1644 st010134 20.9 µM 0.221205251056719 0.41631710526226 no 1405 0.412466310390624 2034 3818134 SGTC_2016 5121758 140 µM 0.216986601602808 0.418002117318346 no 1406 0.414109393284588 1988 2795203 SGTC_754 3474-0146 171 µM 0.216207962186767 0.418313286890643 no 1407 0.414412823699744 1812 24762078 SGTC_2165 5727197 32.143 µM 0.215495502521435 0.418598053690696 no 1408 0.414690509084116 1938 1361712 SGTC_1193 1488-0126 41.5 µM 0.215140249437829 0.418740062638767 no 1409 0.414828987021347 1903 1384710 SGTC_2406 ethylparaben 405.7 µM 0.214565234836189 0.418969941540607 no 1410 0.415053150597914 1665 8434 A possible steroid mimic. SGTC_234 nsc-17383 10.7 µM 0.212933759823952 0.419622321747843 no 1411 0.415689314817717 2018 408974 SGTC_2252 omeprazole 400 µM 0.211738942512762 0.420100235308853 no 1412 0.416155352559592 2000 4594 A proton pump inhibitor. SGTC_83 0170-0301 39.027 µM 0.211392970121666 0.420238642427276 no 1413 0.416290320917142 2042 3089716 SGTC_2029 5175081 200 µM 0.210363445629379 0.420650564552703 no 1414 0.416692010228291 1970 1380876 SGTC_944 3370-0224 231 µM 0.21031509273097 0.420669913127797 no 1415 0.416710878208738 1882 4580514 SGTC_1523 st012844 44.7 µM 0.209686491411237 0.420921467486824 no 1416 0.41695618472333 1932 4274103 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.20894363878654 0.421218784676967 no 1417 0.417246118551995 2003 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2317 5986382 200 µM 0.207974711770843 0.421606652725433 no 1418 0.417624356354646 2009 877883 SGTC_380 3970-0968 6 µM 0.20788096673882 0.421644183538831 no 1419 0.417660955436164 1912 2891601 SGTC_2242 6630449 61.2675 µM 0.207569269594527 0.421768976572618 no 1420 0.417782650522697 1955 691249 YDR170C SEC7 SGTC_2675 theaflavin digallate 100 µM 0.207076396438202 0.421966322405977 no 1421 0.417975097741886 1962 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_477 mead ethanolamide 10 µM 0.206314532133384 0.422271410519384 no 1422 0.418272613858891 2016 16061185 SGTC_1770 st043884 66.3 µM 0.205081002100402 0.422765475718522 no 1423 0.418754419550741 2017 670149 SGTC_506 n9-isopropylolomoucine 153 µM 0.204750409887477 0.422897908340439 no 1424 0.418883566625571 2091 6610355 SGTC_1373 2887-0003 58.5 µM 0.204255099655863 0.423096341999365 no 1425 0.419077077762391 1925 776948 SGTC_622 1348-1566 26.3 µM 0.203954442758751 0.423216802186648 no 1426 0.419194549975596 1996 7340407 SGTC_3335 9143315 29.6265 µM 0.202981621217099 0.42360661874587 no 1427 0.419574698664931 1922 4899691 SGTC_1188 1403-0014 4.57 µM 0.202631189320076 0.423747057656546 no 1428 0.419711655065083 1922 9614867 SGTC_3261 9137475 49.47 µM 0.200879662589795 0.424449143473249 no 1429 0.420396335233706 2064 17027690 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.200570203676012 0.424573212651867 no 1430 0.420517329304971 1844 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2898 9056270 58.44 µM 0.197718788392655 0.425716760604391 no 1431 0.421632544446093 1967 19154699 SGTC_2811 7967822 32.47 µM 0.196288843134784 0.426290469998378 no 1432 0.422192046710255 1992 2232244 SGTC_3050 9093513 49.47 µM 0.193717496375401 0.427322513683515 no 1433 0.423198545613285 1994 25236664 SGTC_1387 3342-1166 1.8 µM 0.190998528056397 0.428414348361897 no 1434 0.424263373185044 1964 3418228 SGTC_278 4092-0821 23.9 µM 0.190754674885098 0.428512297467999 no 1435 0.424358900364928 2025 877900 SGTC_275 trichlorophene 5.69 µM 0.188375017943571 0.429468370420935 no 1436 0.42529134095386 1979 62616 SGTC_2132 5317594 122.667 µM 0.188192804223311 0.429541595416937 no 1437 0.425362756554024 1981 794577 SGTC_1160 4092-0570 10.5 µM 0.18809047843697 0.429582717452059 no 1438 0.425402862497306 1889 4994975 SGTC_921 1561-0023 372 µM 0.185907215903291 0.430460294451256 no 1439 0.426258761689281 1976 24050882 SGTC_409 arachidonic acid 100 µM 0.185646401486383 0.430565153610675 no 1440 0.426361031452628 1976 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.185069940400573 0.430796934327275 no 1441 0.426587089195105 2009 229346 A bile salt which induces apoptosis. SGTC_2430 5571206 200 µM 0.182377995423957 0.431879613019907 no 1442 0.427643046653471 2088 1731771 SGTC_1070 indatraline 8.81 µM 0.181178442831892 0.432362228807837 no 1443 0.428113757350838 1958 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1233 0325-0408 14.2 µM 0.180880749006897 0.432482015574147 no 1444 0.428230589832874 2050 12874 SGTC_1252 0493-0875 34.8 µM 0.180345214943671 0.432697520691436 no 1445 0.428440780578005 1972 3960963 SGTC_1919 st067113 52.3 µM 0.180136445885375 0.432781537208593 no 1446 0.428522725451223 1976 1268243 SGTC_2070 5230947 200 µM 0.180016371004383 0.432829861231365 no 1447 0.428569857973937 2100 2835538 SGTC_1875 nocodazole 6 µM 0.178778193511793 0.433328223056043 no 1448 0.429055934234305 2123 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3071 9117417 49.47 µM 0.17764576288475 0.433784115021631 no 1449 0.429500591261446 2104 45595590 YGL055W OLE1 SGTC_756 0508-1999 28.3 µM 0.177019536024696 0.434036258218986 no 1450 0.42974652219003 1886 6753853 SGTC_1488 4013-0813 75.9 µM 0.176833793340555 0.434111050586278 no 1451 0.429819472041606 1978 2910057 SGTC_40 0327-0103 19.753 µM 0.175304044404562 0.434727118794176 no 1452 0.430420367003487 1969 409036 SGTC_3196 9111891 49.47 µM 0.174442384004829 0.435074200905072 no 1453 0.430758903647804 2097 18891510 SGTC_2736 butenafine 14.65 µM 0.173714926588629 0.435367264190104 no 1454 0.431044753082247 2082 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3035 9091303 49.47 µM 0.17350181836663 0.435453123637865 no 1455 0.431128499353942 2066 25237002 SGTC_2058 5236698 133 µM 0.172887982075325 0.435700449928347 no 1456 0.431369739159095 1989 766665 SGTC_3336 9143619 71.43 µM 0.172838373631869 0.435720439211356 no 1457 0.431389236569905 2102 45595730 SGTC_376 3970-0862 59.1 µM 0.171643968991069 0.436201763443677 no 1458 0.431858719072719 2102 3135186 SGTC_2912 7964298 10.93 µM 0.170621971702758 0.436613685568023 no 1459 0.432260510170072 1982 2975850 SGTC_2211 7117706 200 µM 0.169984412883639 0.436870692314166 no 1460 0.432511197483618 2105 822771 SGTC_2233 sulbentine 40.3845 µM 0.169832472853312 0.436931944893566 no 1461 0.432570944122252 2057 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.169288926489604 0.437151080667628 no 1462 0.432784692826999 2071 616764 SGTC_2966 9084041 48.03 µM 0.169207453297056 0.437183929006746 no 1463 0.432816733721241 1807 17741380 SGTC_2456 5770359 74.46 µM 0.168806752560482 0.437345489716134 no 1464 0.432974323389058 2086 3118787 SGTC_2812 7970281 58.44 µM 0.168111886756551 0.437625681192077 no 1465 0.433247629079818 2087 2233435 SGTC_850 0388-0143 75.9 µM 0.167609374745383 0.437828329142353 no 1466 0.433445297781084 1989 67273 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.16613886729553 0.438421433969912 no 1467 0.434023833747908 1893 641818 YHR062C RPP1 SGTC_1971 st069429 63.5 µM 0.165882128737101 0.438524999436936 no 1468 0.434124855918759 2119 1246522 YGL099W LSG1 SGTC_853 0419-0306 21 µM 0.16534618284623 0.438741207581646 no 1469 0.434335755191046 1953 762713 SGTC_3163 9099914 49.47 µM 0.165080378647038 0.438848443536746 no 1470 0.43444035834402 2132 16268368 SGTC_562 3772-2733 112 µM 0.164772663230014 0.43897259374511 no 1471 0.434561460744111 2099 2876874 YIL048W NEO1 SGTC_1476 4112-3294 3.34 µM 0.163461191350014 0.439501784581467 no 1472 0.435077663472155 2088 704369 SGTC_2608 thymoquinone 42.66 µM 0.163132572144209 0.439634402399147 no 1473 0.435207027218813 2138 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1063 disulfiram 1.84 µM 0.162513105224307 0.439884413352124 no 1474 0.435450904490634 2098 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3030 9087619 49.47 µM 0.162177475259452 0.440019880431389 no 1475 0.435583048554928 2023 25236973 SGTC_686 1319-0111 510 µM 0.160573068718259 0.440667548282781 no 1476 0.436214833831431 2107 4562600 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.160334940327785 0.440763689674062 no 1477 0.436308618247733 2064 97141 SGTC_1882 5615643 20 µM 0.160235134292588 0.440803986164602 no 1478 0.436347926892928 2141 2253075 SGTC_297 0986-0032 24 µM 0.159798354455791 0.440980342370694 no 1479 0.436519960189362 2022 2847425 SGTC_2766 oltipraz 83.91 µM 0.15924235064551 0.441204853917464 no 1480 0.436738969278103 2098 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1222 0366-0074 1.18 µM 0.158770250881705 0.441395500268184 no 1481 0.436924943911187 2136 286520 SGTC_210 3551-0445 56.827 µM 0.157731863603556 0.441814876191596 no 1482 0.437334045626947 2085 2865180 YOR207C RET1 SGTC_1126 isoteolin 1.0172 µM 0.157159393808054 0.442046108845218 no 1483 0.437559614799898 2047 133323 SGTC_2782 7736369 71.43 µM 0.156373879529848 0.442363426795172 no 1484 0.437869162496024 1998 2950836 YOL077C BRX1 SGTC_2134 5324836 1.464 µM 0.15454871888832 0.443100864864865 no 1485 0.438588550249933 2054 699272 SGTC_603 3794-0023 45.9 µM 0.15279255878527 0.443810610084831 no 1486 0.439280933030367 2137 3802260 SGTC_1870 st057514 26.5 µM 0.152377482136059 0.443978388108168 no 1487 0.439444608163155 2042 5393161 SGTC_1180 1193-0155 285 µM 0.152303427207596 0.44400832288773 no 1488 0.439473810967792 2023 2921347 SGTC_2841 9004761 38.96 µM 0.152294221469345 0.444012044090416 no 1489 0.439477441179664 1907 2991039 SGTC_2784 7567673 72.73 µM 0.150143893925707 0.444881397861078 no 1490 0.440325545063005 2117 3471247 SGTC_414 piperonyl butoxide 100 µM 0.148906827104043 0.445381650799971 no 1491 0.440813577014362 2002 5794 A potent inhibitor of cytochrome P450. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.14880789702393 0.445421660540778 no 1492 0.440852609550115 2015 5282362 SGTC_2989 9073649 71.4286 µM 0.146566129306207 0.446328434400841 no 1493 0.441737244902026 2181 21367202 SGTC_2367 9070478 135.38 µM 0.146331160453792 0.446423493418182 no 1494 0.441829984062291 2053 572802 SGTC_997 3996-0078 137 µM 0.146309101452062 0.446432417767831 no 1495 0.441838690628144 2058 735687 SGTC_2797 7859098 81.82 µM 0.146172469969752 0.446487694995087 no 1496 0.441892618943632 2041 972681 SGTC_313 3474-0040 5.03 µM 0.146071678687804 0.446528472959094 no 1497 0.441932401856666 2064 1043375 YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM 0.145951282504568 0.446577183381527 no 1498 0.441979923707444 2181 741646 SGTC_2826 7992541 19.48 µM 0.14337672235622 0.447619002098233 no 1499 0.442996332947049 2165 2985066 SGTC_1724 st037281 8.293 µM 0.142999306003291 0.447771757541331 no 1500 0.443145364644781 2056 574124 YDL195W SEC31 SGTC_2519 cryptotanshinone 88.04 µM 0.142191950699133 0.448098552396896 no 1501 0.443464194800161 2129 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1609 st001574 46.4 µM 0.142146031900133 0.448117140103806 no 1502 0.443482329551358 2094 3960012 SGTC_412 gemfibrozil 100 µM 0.141970254244569 0.44818829509774 no 1503 0.443551750667141 2154 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_791 1348-1292 225 µM 0.140901612725168 0.448620918185907 no 1504 0.443973834044546 2121 5437054 SGTC_946 3434-1334 87.4 µM 0.139808398152413 0.449063552521345 no 1505 0.444405688852275 2115 4047976 SGTC_270 tamoxifen 5.46 µM 0.138791591579217 0.449475306755577 no 1506 0.444807419311669 2180 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2769 toremifene 3.73 µM 0.13779296785093 0.449879750837668 no 1507 0.445202021093084 2103 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1494 4358-1428 177 µM 0.137629349893778 0.449946021326798 no 1508 0.445266679198085 2193 1564571 SGTC_433 pimozide 108 µM 0.134397481127048 0.451255314969136 no 1509 0.446544136667529 1964 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2824 7998404 51.95 µM 0.133805871853944 0.45149504539052 no 1510 0.446778041943062 2083 837851 SGTC_658 3253-0951 102 µM 0.133783141587204 0.451504256445486 no 1511 0.44678702920608 2095 1184878 SGTC_579 4491-1009 110 µM 0.132839772540259 0.451886563717099 no 1512 0.447160049571929 2220 1271041 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.130591146658076 0.452798015250017 no 1513 0.448049373344855 2167 688798 SGTC_3157 9099274 49.47 µM 0.130202487343619 0.452955578644145 no 1514 0.448203113359201 2182 17217662 SGTC_927 2425-1185 123 µM 0.129447394179068 0.453261716330341 no 1515 0.448501823992808 2068 730375 SGTC_1891 st059073 26.2 µM 0.12621629827218 0.454572012206491 no 1516 0.449780355191718 2208 688754 SGTC_2462 5162487 171.77 µM 0.125690351538499 0.45478534485714 no 1517 0.449988519825724 2194 2259986 SGTC_1425 4048-4433 7.33 µM 0.124972608044955 0.45507649446076 no 1518 0.450272617956574 2180 23734946 SGTC_1030 k029-0042 36.7 µM 0.123835674596673 0.455537736020033 no 1519 0.450722692480549 2053 6080581 SGTC_3307 9126885 69.2785 µM 0.121702117685935 0.456403458189256 no 1520 0.451567468018198 2053 24824909 SGTC_2707 st078556 66.6 µM 0.120856157706418 0.456746776457894 no 1521 0.451902484314308 2205 17250899 SGTC_1104 tacrolimus 29.8 µM 0.12052185542769 0.45688245618759 no 1522 0.452034883852282 2179 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1559 coumarin 343 70.1 µM 0.119379959444745 0.457345943244711 no 1523 0.452487168894741 2157 108770 A hepatotoxic, DNA x-linker. SGTC_6 0844-0013 19.835 µM 0.119250577579804 0.45739846204924 no 1524 0.452538418690069 2193 1584900 SGTC_1378 2093-0007 380 nM 0.118755156862131 0.457599570549036 no 1525 0.452734668414362 2101 3618014 SGTC_377 3970-0964 33.1 µM 0.118574136686527 0.457673055645094 no 1526 0.452806378349883 2128 16481235 SGTC_662 k832-1615 104 µM 0.11812325962409 0.457856095363691 no 1527 0.45298499697818 2122 5878478 SGTC_2141 5621638 7.665 µM 0.116670077547899 0.458446095166369 no 1528 0.453560751479793 2183 2856238 SGTC_2720 fluspirilene 36.88 µM 0.116557505765153 0.458491803758321 no 1529 0.453605356801161 2170 3396 An atypical antipsychotic. SGTC_2970 9090938 41.86 µM 0.116173079780867 0.458647900031994 no 1530 0.453757685745777 2210 17217104 SGTC_1772 st048439 82.2 µM 0.115313994576983 0.458996754821044 no 1531 0.454098123145279 2062 2927068 YDL195W SEC31 SGTC_3038 9091290 49.47 µM 0.113714868135356 0.459646207271846 no 1532 0.454731912955149 2180 25236843 SGTC_2712 st079126 47.7 µM 0.113712824134404 0.459647037470251 no 1533 0.454732723138405 2160 3152970 SGTC_625 k213-0058 121 µM 0.113118341757619 0.459888501914607 no 1534 0.454968366852194 2123 3655420 SGTC_975 1335-0046 28.5 µM 0.112913715679117 0.459971619533746 no 1535 0.455049481167517 2078 16486740 SGTC_3125 9127534 49.47 µM 0.111389932687002 0.460590623831838 no 1536 0.455653571466213 2233 1639235 SGTC_1341 1486-1360 280 µM 0.11022074584688 0.461065645854509 no 1537 0.45611715485349 2120 3976547 SGTC_1144 3486-0183 12.5 µM 0.109857188617466 0.461213364731718 no 1538 0.456261317751835 2125 6744069 SGTC_100 0086-0128 49.5915 µM 0.108903756661097 0.461600784124683 no 1539 0.456639413492604 2038 93297 SGTC_3341 9147222 25.867 µM 0.1084618543456 0.46178035995124 no 1540 0.456814668891916 2129 1939759 SGTC_912 3474-0017 2.18 µM 0.105958599031555 0.462797753734511 no 1541 0.457807600196314 2175 3360550 SGTC_2301 7769476 200 µM 0.104872955912166 0.463239065879402 no 1542 0.458238309331662 2154 977820 SGTC_2265 7929201 200 µM 0.104752582917436 0.463288000100323 no 1543 0.458286068154405 2237 1265108 SGTC_1701 st028638 40.4 µM 0.104121393784868 0.463544601184637 no 1544 0.458536506674188 2210 3490878 SGTC_329 k048-0121 21.3 µM 0.104009377384038 0.463590141468211 no 1545 0.458580953429396 2118 6832902 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.103877558768822 0.463643732955866 no 1546 0.458633258127359 2137 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2985 9022375 71.43 µM 0.103503007254939 0.463796012260166 no 1547 0.458781881435402 2130 4939335 SGTC_3172 9105863 49.47 µM 0.102819435085441 0.464073942014096 no 1548 0.459053140024028 2227 2348785 SGTC_1272 0839-0021 27 µM 0.102223972688125 0.464316062005548 no 1549 0.459289449986688 2159 5027250 SGTC_1742 st038235 28.8875 µM 0.100970864340721 0.464825629400296 no 1550 0.459786794417529 2130 564103 YBR002C RER2 SGTC_1064 honokiol 6.76 µM 0.100798882613555 0.464895569039646 no 1551 0.4598550569348 2116 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1617 st002906 78 µM 0.100478615215081 0.465025814755354 no 1552 0.45998217974781 2203 5150859 SGTC_1508 1080-0625 72.9 µM 0.100062898367196 0.465194883252028 no 1553 0.460147195134418 2231 767111 SGTC_1638 st008370 60.6 µM 0.09991357326497 0.465255614032972 no 1554 0.460206470183822 2235 24207134 SGTC_1409 3909-8004 61.9 µM 0.0982335244720117 0.465938948264127 no 1555 0.460873431256029 2139 2119279 SGTC_2412 st077135 33.4 µM 0.0981197892543548 0.465985211982066 no 1556 0.460918586898016 2181 13258915 SGTC_2976 9009005 19.48 µM 0.0980490274450324 0.466013995773413 no 1557 0.460946681308175 2232 2993148 SGTC_2920 7982904 15.77 µM 0.0975401121117193 0.466221012564637 no 1558 0.461148740610587 2143 6456808 SGTC_1833 st055984 71 µM 0.0974470208800817 0.466258881245093 no 1559 0.461185702559154 2110 676288 SGTC_3270 9137563 49.47 µM 0.0957622884415864 0.466944267787286 no 1560 0.461854684563178 2218 17015724 SGTC_2095 5432005 200 µM 0.093499207621524 0.467865093203479 no 1561 0.462753489582486 2204 783734 SGTC_2639 lactacystin 53 µM 0.093090269110125 0.468031504766762 no 1562 0.46291592399608 2208 3870 A proteasome inhibitor. SGTC_22 0964-0034 14.468 µM 0.0926077035330663 0.468227884974293 no 1563 0.46310761175883 2165 138402 SGTC_2879 9041815 71.43 µM 0.091369140045008 0.468731954035547 no 1564 0.463599640916463 2251 4942971 SGTC_1250 0485-0349 40.2 µM 0.0913540584039178 0.468738092254037 no 1565 0.463605632562538 2166 6842794 YDL195W SEC31 SGTC_3233 9132340 49.47 µM 0.090929466639027 0.468910903880917 no 1566 0.463774318090969 2190 17682950 SGTC_1133 3473-0247 50 µM 0.0907349785276826 0.468990063772975 no 1567 0.463851588204861 2015 711311 SGTC_3018 9082602 49.47 µM 0.0906971596549525 0.469005456824867 no 1568 0.463866613798966 2148 17332089 SGTC_2524 avocatin b 10.57 µM 0.0903657376752501 0.46914035430398 no 1569 0.463998291320812 2218 6710748 SGTC_1148 3909-7663 27.7 µM 0.0901533291886833 0.469226812019016 no 1570 0.464082685574701 2241 4084526 SGTC_674 0498-0004 451 µM 0.0899910936707891 0.469292848551082 no 1571 0.464147146166531 2109 4231473 SGTC_845 0330-0138 4.51 µM 0.0894239009444497 0.46952372595888 no 1572 0.464372514677126 2246 9039800 SGTC_3065 9113888 49.47 µM 0.0883006147919827 0.469980992941304 no 1573 0.464818875166295 2221 16648368 SGTC_3221 9128209 49.47 µM 0.08775011055372 0.470205106531014 no 1574 0.465037645369197 2176 16460723 SGTC_529 4076-0302 30.3 µM 0.0867435840633631 0.470614893878771 no 1575 0.465437665943978 2097 5816522 SGTC_2753 fluvastatin 17.09 µM 0.0853979882993611 0.471162775107319 no 1576 0.465972496213308 2185 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3242 9133940 49.47 µM 0.0851242144985881 0.471274253284916 no 1577 0.466081319893199 2230 17248444 SGTC_2851 9015922 71.43 µM 0.0839484559732796 0.471753036840993 no 1578 0.466548706602059 2231 2996893 SGTC_2768 sulfasalazine 50.2 µM 0.0835450337608899 0.471917324846091 no 1579 0.46670908538141 2258 5384001 An antioxidant and salicylic acid derivative. SGTC_887 0885-0007 9.62 µM 0.0802932375604618 0.473241745070599 no 1580 0.468002018247625 2240 5719458 SGTC_2914 7968218 45.32 µM 0.0795515616147089 0.473543863350781 no 1581 0.468296960642607 2240 2977111 SGTC_1317 1273-0028 910 nM 0.0786697007825508 0.473903105088882 no 1582 0.468647673018451 2214 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1007 4101-0031 70 µM 0.0775000141743908 0.474379630485188 no 1583 0.469112889999792 2276 1146276 SGTC_107 0358-0022 2.6945 µM 0.0761133531619104 0.474944597773652 no 1584 0.469664458336071 2227 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3023 9089636 49.47 µM 0.0758242632091937 0.475062388076312 no 1585 0.46977945622007 2294 17249241 SGTC_2972 9093619 59.92 µM 0.0752745655091422 0.47528636955205 no 1586 0.469998128919362 2166 25236256 SGTC_911 3456-4043 236 µM 0.0745994251328323 0.475561474957223 no 1587 0.470266715764017 2220 914281 SGTC_194 1486-1323 56.904 µM 0.0743705004260613 0.475654759578638 no 1588 0.470357790515836 2177 5178754 SGTC_825 1988-2224 89.6 µM 0.0727203402714819 0.476327223173771 no 1589 0.471014331102804 2212 1180859 SGTC_250 brefeldin a 552.239 µM 0.0718892889899427 0.4766659139706 no 1590 0.471345007071265 2266 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2916 7875993 68.79 µM 0.0716707169326012 0.476754994730113 no 1591 0.471431980357998 2297 1299250 SGTC_1282 0886-0010 32.4 µM 0.0702543019237527 0.477332293755328 no 1592 0.471995627184611 2272 2836211 YNL267W PIK1 SGTC_1684 st024538 14.6195 µM 0.0701175815970097 0.477388020434419 no 1593 0.472050036526308 2244 6732859 SGTC_2246 7293507 91.5585 µM 0.0689364589200936 0.477869459786873 no 1594 0.472520098757127 2283 887656 SGTC_906 1165-0455 526 µM 0.0666881297177233 0.478785993615333 no 1595 0.473414992193908 2307 3252859 SGTC_2479 5617353 43.85 µM 0.0665601935051965 0.478838150370066 no 1596 0.47346591820807 2260 2731746 SGTC_144 4161-2749 112.381 µM 0.0662878600253541 0.478949175891885 no 1597 0.473574324131556 2234 797501 YMR168C CEP3 SGTC_103 0844-0104 51.839 µM 0.0662182286314244 0.478977563636772 no 1598 0.473602042138205 2282 5375804 SGTC_742 0kpi-0133 140 µM 0.0656211996664599 0.479220968353245 no 1599 0.47383970529828 2269 2728852 SGTC_1900 st060200 72.8 µM 0.0648536960615534 0.479533885812037 no 1600 0.474145244061919 2274 688945 SGTC_2000 st075254 36.4 µM 0.0647995242513307 0.479555972578266 no 1601 0.474166810124203 2296 17234175 SGTC_1244 0416-0015 52.5 µM 0.0646316448947345 0.479624420238968 no 1602 0.47423364419672 2239 96201 SGTC_3339 9145883 14.936 µM 0.0640275760552731 0.479870715744595 no 1603 0.474474134667523 2285 2030670 SGTC_2673 kobusone 100 µM 0.0635676482376547 0.480058246143559 no 1604 0.474657246294308 2293 6710676 An epoxy ketone and protein crosslinker. SGTC_793 0488-0545 106 µM 0.0635013298846618 0.480085287071792 no 1605 0.474683650144159 2140 292548 SGTC_3284 9108171 64.8615 µM 0.0633355715889231 0.480152874467127 no 1606 0.474749645290117 2213 8687505 SGTC_2262 9014885 67.46 µM 0.0625381007332891 0.480478048505333 no 1607 0.47506716065391 2266 6457424 SGTC_3353 9151644 39.2805 µM 0.061209247943835 0.481019925809651 no 1608 0.47559628237522 2245 4909158 SGTC_392 N-ethylmaleimide 8.33 µM 0.0608288479682478 0.481175051157987 no 1609 0.475747757749416 2251 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1765 st044815 90.4 µM 0.0600009773367588 0.481512662788222 no 1610 0.47607742814614 2197 645695 SGTC_596 1155-0152 116 µM 0.058895186347534 0.481963632991537 no 1611 0.476517796068212 2295 280313 SGTC_1279 0874-0590 65.2 µM 0.0584437380756705 0.482147751955921 no 1612 0.476697588171601 2244 3523074 SGTC_2409 alverine citrate 63.97 µM 0.0576509809773152 0.482471079729826 no 1613 0.47701332011089 2248 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_974 1326-0144 138 µM 0.0569637226894563 0.482751388912895 no 1614 0.477287046647739 2251 5411856 SGTC_1404 3909-7820 48.3 µM 0.055798570712554 0.483226634017587 no 1615 0.477751136789004 2296 23741373 SGTC_1723 st034307 2.5525 µM 0.0557275844038721 0.483255588867895 no 1616 0.477779412233127 2278 867466 SGTC_1857 st056007 79.3 µM 0.0551612020002892 0.483486615690646 no 1617 0.47800501908431 2306 619834 SGTC_584 0986-0246 15.4 µM 0.0547532410422141 0.48365302600181 no 1618 0.47816752636266 2317 53315 YDR232W HEM1 SGTC_2930 9013230 14.89 µM 0.0544749231567815 0.483766555574476 no 1619 0.478278393668997 2287 2995857 SGTC_396 dithiazanine 1.25 µM 0.0539860252136021 0.483965986738531 no 1620 0.478473149134243 2231 10578 An antihelmenthic. SGTC_2043 5101342 149 µM 0.0539047311106142 0.483999148605197 no 1621 0.478505533633637 2265 678451 SGTC_2184 6075246 200 µM 0.0536395412832215 0.484107326834925 no 1622 0.478611176227602 2248 2267320 SGTC_2855 9016525 58.44 µM 0.0519884933596457 0.484780860728971 no 1623 0.479268930992291 2306 43811474 SGTC_1017 4239-0030 168 µM 0.0518565712717049 0.484834679356217 no 1624 0.479321489395683 2193 1149593 SGTC_2521 angolensin 13.4 µM 0.0513609240234534 0.48503688491212 no 1625 0.479518960882986 2256 821428 A flavenoid. SGTC_2078 5212016 200 µM 0.0512995885302494 0.485061907769949 no 1626 0.47954339798991 2333 1899708 SGTC_966 1300-0360 30.2 µM 0.0509860924853324 0.48518980473093 no 1627 0.479668301361582 2290 70588 SGTC_274 sirtinol 40.1 µM 0.0493219228442961 0.485868761105311 no 1628 0.480331374436951 2225 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2659 sanguinarine 24.21 µM 0.0488683122771131 0.48605383463404 no 1629 0.480512120908804 2316 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3189 9110682 49.47 µM 0.0488555972328779 0.486059022427253 no 1630 0.480517187425804 2277 17122418 SGTC_2267 7931562 200 µM 0.0487137511648579 0.486116896398178 no 1631 0.480573708521032 2288 934880 SGTC_2036 5160441 105 µM 0.0465146147467431 0.487014192730065 no 1632 0.481450042905559 2278 134534 YIL048W NEO1 SGTC_559 1550-0661 158 µM 0.0463451058691042 0.48708335889093 no 1633 0.481517594313054 2262 5830875 SGTC_157 1348-1695 65.819 µM 0.0439439250232432 0.488063174054547 no 1634 0.48247455099677 2330 5380510 SGTC_856 0433-0016 11.3 µM 0.0437289562485685 0.488150896857027 no 1635 0.482560228769589 2244 3911780 SGTC_2743 auranofin 4.32 µM 0.0428276951015222 0.488518682757606 no 1636 0.482919443370216 2304 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1982 st072467 71.9 µM 0.0426662098408098 0.488584582569194 no 1637 0.482983807834778 2235 3163533 SGTC_1741 st038134 10.228 µM 0.0422327137700981 0.488761487615143 no 1638 0.483156591999469 2301 1272587 SGTC_2445 5742597 35.57 µM 0.0420747900782028 0.488825935112704 no 1639 0.483219538486299 2282 1774255 SGTC_1328 1441-0025 69.2 µM 0.0412043986484 0.489181140645834 no 1640 0.483566473519132 2333 4562601 SGTC_842 0271-0008 11.1 µM 0.041028921230369 0.489252753784793 no 1641 0.483636419730532 2315 1221709 SGTC_1748 st037455 53.6035 µM 0.0406568697389562 0.489404590847724 no 1642 0.48378472305298 2300 580690 SGTC_2755 lomerizine 42.69 µM 0.0397674160884267 0.489767589876439 no 1643 0.484139276933314 2320 3949 A calcium channel blocker. SGTC_237 nikkomycin 200 µM 0.0392338492194327 0.489985350396907 no 1644 0.484351973314433 2327 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1312 1218-2183 165 µM 0.0366141676746449 0.49105454284977 no 1645 0.485396323467249 2340 6744073 SGTC_146 3448-8650 53.125 µM 0.0339382898935875 0.49214673744566 no 1646 0.486463179921994 2260 2891488 YIL048W NEO1 SGTC_2276 7947513 42.08 µM 0.0338943907355946 0.492164655975772 no 1647 0.486480683082193 2197 2105100 SGTC_794 k038-0031 316 µM 0.0326342649171345 0.492679014180412 no 1648 0.486983122461184 2339 6624242 SGTC_526 4469-0568 170 µM 0.0313820396120318 0.493190159613489 no 1649 0.487482432204987 2344 2901964 SGTC_2142 5622915 118.518 µM 0.029916888096495 0.493788233460647 no 1650 0.488066668562252 2332 5322196 SGTC_1088 bifonazole 369 nM 0.0293490245341053 0.494020038807141 no 1651 0.488293113899723 2349 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1351 1496-0003 46.5 µM 0.0292235790079291 0.494071246705968 no 1652 0.488343137966861 2345 3891978 SGTC_108 0509-0257 621.132 µM 0.0282205075260537 0.494480712204214 no 1653 0.488743140548232 2346 536624 SGTC_1107 amlodipine 47 µM 0.0280784542519877 0.494538700490416 no 1654 0.488799789156844 2336 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2013 4024628 200 µM 0.02798848003987 0.494575429378844 no 1655 0.488835669572656 2327 5230760 SGTC_2143 5623677 140.463 µM 0.0268963659537726 0.495021251099134 no 1656 0.489271196009549 2359 5375313 SGTC_2932 9016711 44.54 µM 0.026527178560729 0.495171961841732 no 1657 0.489418427933448 2358 7117328 SGTC_3067 9117431 49.47 µM 0.0265130228953208 0.495177740522155 no 1658 0.48942407324132 2331 17150885 SGTC_2693 st077581 40.7 µM 0.0252066460833831 0.495711038908377 no 1659 0.48994506791692 2376 25238761 SGTC_3154 9100113 49.47 µM 0.024499802755918 0.495999594749645 no 1660 0.490226970523363 2334 25237525 SGTC_1031 k035-0009 16 µM 0.0243928871492649 0.496043241273656 no 1661 0.490269610935905 2354 5180959 SGTC_1953 st076800 12.1 µM 0.0243841413303774 0.496046811611335 no 1662 0.490273098975339 2271 297591 SGTC_3253 9135987 49.47 µM 0.0237274627322929 0.496314890805025 no 1663 0.490535000038417 2355 4182430 SGTC_3200 9114385 49.47 µM 0.0223127553914038 0.496892429365688 no 1664 0.491099237042478 2329 17018030 YLR208W SEC13 SGTC_2882 9058044 58.44 µM 0.0222400250938293 0.496922120888324 no 1665 0.491128245034919 2345 18076804 SGTC_1213 1315-0166 115 µM 0.0219112141100143 0.497056355373745 no 1666 0.491259389678584 2294 768401 SGTC_2457 5731572 11.68 µM 0.0214162284582075 0.497258429977695 no 1667 0.491456814048542 2371 2865357 SGTC_2386 9075165 157.42 µM 0.0207258823774203 0.497540260342176 no 1668 0.491732161150432 2363 16452277 SGTC_2342 7990637 118.86 µM 0.0203577113729538 0.497690564840091 no 1669 0.491879009144046 2346 2033102 YER133W GLC7 SGTC_1530 rhein 70.4 µM 0.0198951696298612 0.497879396317124 no 1670 0.492063499230356 2375 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2455 5377712 9.75 µM 0.0186374574194406 0.498392856372174 no 1671 0.492565160659908 2314 2243908 SGTC_829 1635-0120 117 µM 0.0165146557160583 0.499259494152456 no 1672 0.493411905056039 2370 285054 SGTC_2210 7115885 190.385 µM 0.0151944522669397 0.499798471711215 no 1673 0.493938523800969 2379 2927039 SGTC_2041 5107442 45.335 µM 0.0151501126878252 0.49981657350743 no 1674 0.493956210697909 2379 793005 SGTC_1225 1216-0074 20.6 µM 0.0150271275890064 0.499866782628113 no 1675 0.494005269068866 2375 4241466 SGTC_769 0302-0231 76 µM 0.0149679515531294 0.499890941464053 no 1676 0.494028874236701 2374 571869 YER009W NTF2 SGTC_2867 9039098 71.43 µM 0.0144336831277947 0.499890941464053 no 1677 0.494241993467843 2393 6463460 SGTC_598 3937-0236 20.2 µM 0.013548628282816 0.499529614634697 no 1678 0.494595044697447 2370 1379313 SGTC_530 4358-1714 28 µM 0.0135386613014826 0.499525545580297 no 1679 0.494599020583043 2326 1564641 SGTC_1567 st069303 68.4 µM 0.011961078195222 0.498881492754731 no 1680 0.495228333967312 2367 5581319 SGTC_604 1000-0114 314 µM 0.0113301009424412 0.498623895204625 no 1681 0.495480040398481 2384 1572745 SGTC_1128 3448-9350 235 µM 0.0110991098252659 0.49852959282102 no 1682 0.495572186726632 2347 619386 SGTC_3102 9121669 49.47 µM 0.010668562249671 0.498353821511974 no 1683 0.495743940183857 2358 41905072 SGTC_1103 duloxetine 36.1 µM 0.0101116397185257 0.498126458029603 no 1684 0.495966108133263 2381 60835 A selective serotonin reuptake inhibitor. SGTC_1988 st071872 53.4 µM 0.00994106095789777 0.498056819412077 no 1685 0.49603415579251 2395 16414116 SGTC_2157 5649910 96.377 µM 0.00988080768507713 0.498032221084536 no 1686 0.496058192190031 2382 2858091 SGTC_2405 ticlatone 3.52 µM 0.00936518653924277 0.49782171967567 no 1687 0.49626388573945 2389 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1310 1188-0297 994 nM 0.00865506378586514 0.497531814338887 no 1688 0.49654717222493 2382 1588352 SGTC_1203 3992-3522 103 µM 0.00826814756671447 0.497373857571996 no 1689 0.496701523936964 2390 5322312 SGTC_815 1582-0027 36.9 µM 0.0080788106236926 0.497296561784333 no 1690 0.496777055925637 2383 3128206 SGTC_2656 pseudo-anisatin 100 µM 0.00804894134013218 0.49728436781932 no 1691 0.496788971658311 2392 6708809 A neurotoxin. SGTC_2183 6420625 130.508 µM 0.00772520863269998 0.497152205949191 no 1692 0.496918118305383 2386 2897619 SGTC_421 streptovitacin 30 mM 0.00747556149041236 0.497050289264265 no 1693 0.497017710228816 2341 91467 include heat shock SGTC_2931 9014674 55.67 µM 0.00501330662053195 0.496045102447166 no 1694 0.497999988402253 2394 2996810 SGTC_2425 5628681 7.85 µM 0.00388585516623601 0.495584841543812 no 1695 0.498449771980047 2393 5714958 SGTC_857 0438-0306 1.35 µM 0.00303707483423397 0.495238346742179 no 1696 0.498788384302503 2391 4686136 SGTC_1636 st007707 68.9 µM 0.00287658563014812 0.495172831158448 no 1697 0.498852409951608 2397 403051 SGTC_3305 9127027 53.8275 µM 0.00276199608664865 0.495126053008444 no 1698 0.498898124383698 2394 41905295 SGTC_3259 9138485 49.47 µM 0.00228871946253873 0.494932851062914 no 1699 0.499086933835559 2400 17646153 SGTC_197 4544-0043 41.561 µM 0.00213374267709673 0.494869586380646 no 1700 0.499148760476538 2398 896523 SGTC_1469 k284-2957 126 µM 0.00205615244354872 0.494837912514384 no 1701 0.499179714433313 2391 23884841 SGTC_1729 st035615 45.989 µM 0.00177764443216299 0.494724220311205 no 1702 0.499290822849992 2388 17385451 SGTC_2621 lithochol-11-enic acid 100 µM 0.000666800533295649 0.494270757314584 no 1703 0.499733985094387 2403 6708711 SGTC_159 3970-0959 50 µM 0 0.493998562940407 no 1704 0.5 2405 6615653 SGTC_1191 1487-1166 10.6 µM 0 0.493998562940407 no 1705 0.5 2406 3955771 SGTC_1060 3448-7350 82 µM -0.000132632401569862 0.493944421450904 no 1706 0.499947087327418 2408 570178 SGTC_1801 st050089 28.441 µM -0.000183299098499995 0.493923738974305 no 1707 0.499926874240058 2398 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2918 7977171 22.06 µM -0.00074399428115127 0.49369486064174 no 1708 0.499703189252254 2407 2236483 SGTC_1843 st055809 45.5 µM -0.00233344948275767 0.493046049306606 no 1709 0.499069089186947 2424 16413835 SGTC_890 0929-0006 47.2 µM -0.00235409196592923 0.49303762321783 no 1710 0.499060854050256 2409 1378169 SGTC_2606 farnesol 9.78 µM -0.00271341582877802 0.492890950726878 no 1711 0.498917505029924 2410 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1158 4092-0494 91.8 µM -0.00272098241338036 0.492887862131216 no 1712 0.498914486410552 2429 1148199 SGTC_3148 9097893 49.47 µM -0.00294677041810683 0.49279569817644 no 1713 0.498824410390945 2412 17174100 SGTC_11 0438-0307 1.3 µM -0.00325859639084192 0.492668415188658 no 1714 0.498700010425576 2412 4011476 SGTC_2098 5376439 882.5 nM -0.00481081743088928 0.49203483169654 no 1715 0.498080768926632 2423 2844116 SGTC_1071 trifluoperazine 6.31 µM -0.00504505420769681 0.4919392229504 no 1716 0.497987323107603 2424 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3122 9126309 49.47 µM -0.00504928146725572 0.491937497508311 no 1717 0.497985636696515 2412 17591206 SGTC_139 0099-0334 718.624 µM -0.00526637641723242 0.491848885986283 no 1718 0.4978990294943 2414 97690 SGTC_3110 9122132 49.47 µM -0.00573260569812242 0.491658586811562 no 1719 0.497713033736163 2451 918317 SGTC_368 fentichlor 4.58 µM -0.006619838664571 0.491296453315261 no 1720 0.497359085755754 2416 7329 A pesticide. SGTC_2567 aureobasidin a 60 nM -0.00675385109833391 0.491241755342747 no 1721 0.497305623725128 2436 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1699 st031318 29.054 µM -0.00676193348178366 0.49123845647509 no 1722 0.49730239939427 2433 5340658 SGTC_39 0986-0283 58.349 µM -0.00758304075448288 0.490903320350681 no 1723 0.496974833421501 2418 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_522 1273-0010 11.6 µM -0.00788022015469552 0.490782027717681 no 1724 0.496856279537845 2486 5705015 SGTC_1278 0874-0585 172 µM -0.00883132533969054 0.490393843567049 no 1725 0.496476856726422 2422 766306 SGTC_1470 k295-0292 231 µM -0.00894029664816113 0.490349368582001 no 1726 0.496433385180383 2454 5045612 SGTC_2089 5281248 129.67 µM -0.00917694530804694 0.490252784438456 no 1727 0.496338979898037 2428 2737878 SGTC_687 k029-0044 34.9 µM -0.00933995865465016 0.490186253633321 no 1728 0.496273949769096 2421 5829338 SGTC_1062 mesoridazine 14.2 µM -0.00949850578369717 0.49012154589207 no 1729 0.496210701421769 2423 4078 A neuroleptic. SGTC_1778 st046819 58.9 µM -0.0100824747233047 0.489883213267143 no 1730 0.495977742689874 2422 671715 SGTC_2146 5545642 200 µM -0.0105278460665923 0.489701448281192 no 1731 0.495800074666122 2419 825326 SGTC_339 3091-4833 71.4 µM -0.0105346617529945 0.489698666679267 no 1732 0.495797355751425 2438 3240077 SGTC_1958 st076513 41.9 µM -0.0106011890162193 0.489671515755199 no 1733 0.495770816695326 2430 732122 YGL099W LSG1 SGTC_2358 9037157 4 µM -0.0111063217438999 0.489465363943173 no 1734 0.495569309764693 2438 2388925 SGTC_1385 3091-4834 14.1 µM -0.0114803734232595 0.489312709971832 no 1735 0.495420094251366 2439 4072814 SGTC_936 3005-4620 401 µM -0.0120844785123995 0.489066172378653 no 1736 0.495179107921278 2427 777207 SGTC_688 0527-0193 473 µM -0.0137648051487768 0.48838044692815 no 1737 0.494508810647694 2428 4007154 SGTC_1675 st018485 24.5 µM -0.014178220434507 0.488211741236424 no 1738 0.494343897908556 2470 3323024 SGTC_1625 st003711 30.1 µM -0.0149023232637946 0.487916255887599 no 1739 0.494055053216219 2443 24207034 YER133W GLC7 SGTC_1139 k015-0024 46.9 µM -0.0159244424899206 0.487499170024107 no 1740 0.49364733509321 2427 2766652 SGTC_440 fluspirilene 35.1 µM -0.0168869701436031 0.487106413583078 no 1741 0.493263393802758 2552 3396 An atypical antipsychotic. SGTC_2552 juarezic acid 87.02 µM -0.0176367557579984 0.486800474520423 no 1742 0.492964317188478 2428 1549512 SGTC_1944 st076371 56.9 µM -0.0183666166494685 0.486502672909437 no 1743 0.492673192001459 2448 24208455 SGTC_366 0181-0206 4.31 µM -0.019044424279728 0.486226117076041 no 1744 0.492402833187882 2441 274874 SGTC_3022 9087993 49.47 µM -0.0191992704330755 0.486162938412523 no 1745 0.492341069803186 2439 17173644 SGTC_891 0929-0073 133 µM -0.0192734370297267 0.486132677877663 no 1746 0.492311487085856 2505 5603632 SGTC_920 mycophenolic acid 780.421 nM -0.020228943605941 0.485742831138516 no 1747 0.491930369473953 2454 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1671 st016596 74.5 µM -0.0211411306549758 0.485370671476748 no 1748 0.49156653734996 2458 2829167 SGTC_3025 9087895 49.47 µM -0.0211804645968835 0.48535462405835 no 1749 0.491550848890357 2447 17173641 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.022385352868461 0.484863066680598 no 1750 0.491070282071556 2452 6857784 SGTC_288 1315-0019 35.1 µM -0.0233786560708207 0.484457846771965 no 1751 0.490674115170483 2471 6811474 SGTC_795 0685-0265 78 µM -0.0238677226611321 0.484258337008032 no 1752 0.490479060264904 2446 302754 SGTC_2166 5933061 31.504 µM -0.0245585714029199 0.483976518985408 no 1753 0.49020353227755 2501 2877375 SGTC_547 1120-0019 610 nM -0.024738909322945 0.483902955024534 no 1754 0.490131609708561 2454 3676939 SGTC_784 4579-0127 173 µM -0.0260778946495956 0.483356769599865 no 1755 0.489597604290074 2509 1948547 SGTC_2202 7226349 200 µM -0.0264163478105127 0.483218716095536 no 1756 0.489462627516419 2451 844334 SGTC_3075 9116269 49.47 µM -0.0296722552171519 0.481890751476854 no 1757 0.488164219652289 2487 17015205 YNL244C SUI1 SGTC_1774 st048371 48.465 µM -0.029912236287202 0.481792879813935 no 1758 0.488068523535484 2453 4242727 SGTC_2886 9058944 51.95 µM -0.0323264771976293 0.480808340138248 no 1759 0.487105847242565 2457 4949929 SGTC_1471 k673-0312 37 µM -0.0334241436332426 0.480360744551756 no 1760 0.486668178290744 2476 24099884 SGTC_67 0335-0847 266 µM -0.0335021015915359 0.480328956559939 no 1761 0.486637094973215 2536 4552207 YOR254C SEC63 SGTC_365 0121-0052 13.6 µM -0.0339951007030903 0.480127935066002 no 1762 0.486440528758607 2487 3101739 SGTC_1501 4491-0275 38.4 µM -0.0340759003789892 0.480094989297516 no 1763 0.486408313016666 2460 5104718 SGTC_1111 tnp00062 510.699 nM -0.0348831757617953 0.479765833254006 no 1764 0.486086448122843 2503 676306 SGTC_303 1348-1668 34.2 µM -0.0378332194043729 0.478563110327673 no 1765 0.484910329034755 2492 5380509 SGTC_224 benfluorex 43.875 µM -0.0379831559176 0.478501986832546 no 1766 0.484850555983596 2473 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1867 st057372 64 µM -0.0396938937561261 0.477804619302607 no 1767 0.48416858495936 2468 688837 SGTC_2362 9071156 126 µM -0.0399507373103204 0.477699925057251 no 1768 0.48406620042018 2505 653133 SGTC_2890 9046729 58.44 µM -0.0425734403588837 0.476630951510268 no 1769 0.483020783905599 2513 903329 SGTC_2924 9010168 62.78 µM -0.0430568766500449 0.476433928416379 no 1770 0.482828097422449 2530 2993929 SGTC_101 0490-5701 117.494 µM -0.0439160950994366 0.476083770615576 no 1771 0.482485642822115 2499 4661669 SGTC_153 4077-0274 519.67 µM -0.0440149482532653 0.476043486111059 no 1772 0.48244624421603 2493 3121976 SGTC_265 mycophenolic acid 32.932 µM -0.0448722026459786 0.475694149265026 no 1773 0.482104586797077 2514 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_826 1683-5028 118 µM -0.0465572291260783 0.475007544510915 no 1774 0.481433060626194 2529 722377 SGTC_1194 1488-0194 225 µM -0.0465902304055475 0.474994098076547 no 1775 0.481419909291605 2484 1391452 SGTC_2477 5967686 25.23 µM -0.0466055517618423 0.474987855370335 no 1776 0.481413803587237 2505 776118 SGTC_615 k087-0205 167 µM -0.0470350376239656 0.474812863310945 no 1777 0.48124265121714 2496 9642773 SGTC_2380 9035439 200 µM -0.0493242678532963 0.473880209666708 no 1778 0.480330440050977 2605 6462575 SGTC_253 dyclonine 31.25 µM -0.0509802776606061 0.473205624833678 no 1779 0.479670618128093 2490 3180 An oral anasthetic. SGTC_2390 9097792 176.6 µM -0.0513173824299176 0.473068312674967 no 1780 0.479536308588782 2514 4497149 SGTC_337 1315-0038 354 µM -0.051881564549825 0.472838512756614 no 1781 0.47931153192412 2520 1626437 SGTC_698 k064-0052 127 µM -0.0525258128082556 0.472576111747558 no 1782 0.479054864036464 2482 5088751 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0531337497552036 0.472328511173997 no 1783 0.478812670503521 2493 165521 SGTC_364 0083-0097 67.7 µM -0.054659623702923 0.471707100509174 no 1784 0.478204818431959 2574 5207356 SGTC_1692 fluoroquinolonic acid 71 µM -0.0547409390849214 0.47167398681931 no 1785 0.478172426784171 2607 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_811 0416-0114 265 µM -0.0562061677172027 0.471077342261958 no 1786 0.477588783902195 2574 6612453 SGTC_2484 5809818 12.04 µM -0.0579746153720132 0.470357312777431 no 1787 0.47688442425368 2546 2870548 SGTC_973 1325-0077 65.9 µM -0.0599639320491415 0.469547471648749 no 1788 0.476092180515038 2566 2835149 SGTC_724 3910-0327 137 µM -0.0612419201131814 0.469027275174988 no 1789 0.475583272472621 2539 2885483 SGTC_3249 9135183 49.47 µM -0.0613299126008932 0.468991460358054 no 1790 0.475548234411591 2654 4902779 SGTC_3011 9081274 71.4286 µM -0.0614137138318388 0.46895735170518 no 1791 0.47551486545871 2552 6625322 SGTC_651 3253-0966 34.4 µM -0.061476548236711 0.468931777088242 no 1792 0.475489845434158 2532 781462 SGTC_2987 9018338 71.43 µM -0.0618673031189146 0.468772736425942 no 1793 0.475334252965145 2492 5055682 SGTC_1505 k297-0037 20.6 µM -0.0620744874758346 0.468688412596431 no 1794 0.475251756926222 2538 4089396 SGTC_2902 5787006 60.46 µM -0.0627083166557994 0.46843045348119 no 1795 0.474999387348223 2525 591003 SGTC_749 1000-0129 128 µM -0.063195657149201 0.468232122105334 no 1796 0.474805351481015 2583 708470 SGTC_710 3448-4187 58 µM -0.0632501802048963 0.468209933524152 no 1797 0.474783643357405 2539 3946412 SGTC_3012 9080433 71.4286 µM -0.0633034237468842 0.468188265746323 no 1798 0.474762444739002 2512 17688859 SGTC_1521 st012942 49.4 µM -0.0634497076863578 0.468128735107661 no 1799 0.474704202974802 2719 24207259 SGTC_2497 7-hydroxyflavone 100 µM -0.0635770061749078 0.468076931228712 no 1800 0.474653520553772 2605 5281894 SGTC_2744 captopril 92.04 µM -0.0648176596784639 0.467572078075095 no 1801 0.474159590313635 2532 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1228 0124-0032 52.5 µM -0.0649636061671825 0.467512692186465 no 1802 0.474101488544821 2560 X1228 SGTC_1467 k284-1082 293 µM -0.0661000341878659 0.467050302419065 no 1803 0.47364909181732 2530 3334705 SGTC_2685 mycophenolic acid 18.85 µM -0.0661717101516431 0.467021140391122 no 1804 0.473620559712221 2562 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2464 5717415 7.67 µM -0.0671144322401289 0.466637601735895 no 1805 0.473245302267502 2536 5285744 SGTC_1672 st016598 6.51 µM -0.0675569576711264 0.466457574600126 no 1806 0.473069159940437 2597 4665860 YNL267W PIK1 SGTC_1499 4480-0877 67.3 µM -0.0679674331232909 0.466290592094189 no 1807 0.472905779457878 2522 2861909 SGTC_2795 7780010 54.55 µM -0.0686804744223129 0.466000539120413 no 1808 0.472621980325941 2606 953673 SGTC_1166 k206-0078 225 µM -0.0692815762470614 0.465756035227829 no 1809 0.472382745260351 2523 5404595 SGTC_977 1348-1378 135 µM -0.0700448388133647 0.465445589547373 no 1810 0.472078985521233 2520 X977 SGTC_38 0929-0051 58.268 µM -0.0708788495314222 0.465106392158855 no 1811 0.47174708833004 2584 1379719 SGTC_2080 5212524 12.4 µM -0.0715975069236509 0.464814130017264 no 1812 0.471461112085998 2538 260183 SGTC_2624 nerol 100 µM -0.0733029854436018 0.464120625705023 no 1813 0.470782508026597 2524 637566 A natural product oil. SGTC_1161 k007-0610 110 µM -0.0738504021670853 0.463898050857419 no 1814 0.470564710678113 2543 5843850 SGTC_3224 9130643 49.47 µM -0.0744420416594414 0.463657508125617 no 1815 0.470329328588988 2625 17644395 SGTC_3179 9107801 49.47 µM -0.0755702254975066 0.463198859576295 no 1816 0.469880512658279 2560 4818259 SGTC_15 0266-0086 27.098 µM -0.0756367188522053 0.463171829083309 no 1817 0.469854061352169 2543 1712902 YIL048W NEO1 SGTC_472 calcifediol 10 µM -0.0759609480658012 0.463040027741739 no 1818 0.469725083661881 2612 5283731 A vitamin D metabolite. SGTC_3093 9117344 49.47 µM -0.0762016255142587 0.462942193373786 no 1819 0.469629344739119 2681 24824913 SGTC_1105 epirubicin 18.1 µM -0.0784773469003081 0.46201723384461 no 1820 0.468724174597222 2553 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1847 st056231 15 µM -0.0796428975057337 0.46154357882232 no 1821 0.468260638140999 2543 5393180 SGTC_2336 9001819 198.65 µM -0.0804042948980332 0.461234192496025 no 1822 0.467957855565934 2618 2989602 SGTC_637 1181-0519 7.26 µM -0.0808981735445919 0.461033522308151 no 1823 0.467761466253288 2547 6252091 YGR060W ERG25 SGTC_3150 9097574 49.47 µM -0.081198629253999 0.460911447566932 no 1824 0.467641994807573 2578 17217476 SGTC_444 curcumin 90.4 µM -0.0818264516985395 0.460656376075128 no 1825 0.467392360594622 2619 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_300 r073-0011 5.04 µM -0.0821895668561261 0.460508857152831 no 1826 0.467247984909452 2545 2735780 SGTC_940 3232-1287 54.8 µM -0.0836070524390077 0.459933042610104 no 1827 0.466684429768254 2537 1585493 YIL048W NEO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0840565829241647 0.459750450702247 no 1828 0.466505722115941 2636 7104 SGTC_2416 tofa 880 nM -0.0845449620992028 0.459552088715958 no 1829 0.466311578097067 2606 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1303 1160-0052 261 µM -0.0851725667138877 0.459297193172933 no 1830 0.466062099951286 2553 3562476 SGTC_2607 solasodine 47.35 µM -0.087425767234371 0.458382216177359 no 1831 0.465166544249239 2595 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2191 5911152 200 µM -0.0877709464672894 0.458242065557762 no 1832 0.465029364991166 2568 2875902 SGTC_2763 lisinopril 49.32 µM -0.0878854177616566 0.458195588754027 no 1833 0.464983873347253 2541 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_206 4546-0025 72.014 µM -0.0888446218176179 0.457806162209742 no 1834 0.464602697399908 2581 6620745 YIL048W NEO1 SGTC_1323 1348-1351 11.2 µM -0.0891535203020018 0.457680761346899 no 1835 0.464479951822232 2578 6989654 SGTC_1021 4476-0760 85.3 µM -0.090962691857699 0.456946392514828 no 1836 0.463761117850349 2574 746768 SGTC_3079 9117512 49.47 µM -0.0913455735825562 0.456790994062749 no 1837 0.463609003422581 2542 7185044 SGTC_176 1486-1328 72.834 µM -0.0915628306819323 0.456702819855703 no 1838 0.463522692084329 2631 22310231 SGTC_641 4092-0595 30 µM -0.0918442856792604 0.456588593979973 no 1839 0.463410878924816 2608 786260 SGTC_1738 st035555 74 µM -0.0920380375555468 0.456509963678881 no 1840 0.463333909117753 2654 5331140 SGTC_3173 9105693 49.47 µM -0.0926356835226884 0.456267431827731 no 1841 0.463096497135303 2659 17096658 SGTC_3132 9126706 49.47 µM -0.0927163739116841 0.456234687953257 no 1842 0.463064444272062 2779 850858 SGTC_3104 9120930 49.47 µM -0.094229342874969 0.455620785772595 no 1843 0.46246348811323 2641 17014836 SGTC_1375 2910-0797 186 µM -0.0962902583763625 0.454784719572665 no 1844 0.461645023912802 2645 742508 SGTC_3263 9137018 49.47 µM -0.0963872395500831 0.454745381437144 no 1845 0.461606513149695 2577 43844957 SGTC_217 ketoconazole 989 nM -0.0963873741857996 0.454745326825636 no 1846 0.461606459686742 2580 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3130 9127414 49.47 µM -0.0975040453856598 0.454292407457856 no 1847 0.461163060893435 2561 1494646 SGTC_2347 9049783 174.81 µM -0.0984748615656482 0.453898694831926 no 1848 0.46077761624388 2665 6467988 YPL169C MEX67 SGTC_12 0849-0099 9.267 µM -0.100813955149861 0.452950266744449 no 1849 0.459849074337529 2556 6071388 SGTC_1924 st058459 75.1 µM -0.102275114940236 0.452357948721474 no 1850 0.459269153557081 2584 688683 SGTC_1554 st069299 38.7 µM -0.102838716540418 0.452129506839121 no 1851 0.459045488396995 2663 24207999 SGTC_1999 st074831 12.5 µM -0.103500015102943 0.451861486135994 no 1852 0.458783068754664 2617 17112523 SGTC_355 1311-2252 105 µM -0.103632652768744 0.45180773145049 no 1853 0.458730437003784 2635 5338538 SGTC_3246 9135460 32.98 µM -0.103922081542682 0.451690436370089 no 1854 0.458615591724173 2589 41446951 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.104093588652435 0.45162093269149 no 1855 0.458547539366633 2711 688751 SGTC_474 dl-dihydrosphingosine 5 µM -0.104454452998644 0.451474696371703 no 1856 0.458404355864237 2747 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1907 st060210 83.7 µM -0.104634662757049 0.451401670806945 no 1857 0.458332854382 2663 688793 SGTC_2911 7942208 15.64 µM -0.105810587198924 0.450925196887612 no 1858 0.457866318289638 2669 1243384 SGTC_1367 1812-0510 76.9 µM -0.106494471883994 0.450648125489315 no 1859 0.457595020633001 2641 1142582 YDR527W RBA50 SGTC_3107 9121808 49.47 µM -0.107055345629434 0.450420909109901 no 1860 0.457372536265488 2589 662681 SGTC_803 4488-1585 147 µM -0.108073225049773 0.450008596049592 no 1861 0.45696880352368 2662 747204 SGTC_1006 4099-6547 255 µM -0.108859045940025 0.449690319968741 no 1862 0.456657145072146 2681 3146833 SGTC_3264 9137442 49.47 µM -0.109684825845958 0.449355894414662 no 1863 0.456329667509724 2726 17015726 SGTC_48 0382-0018 55 µM -0.110806169266425 0.448901828748027 no 1864 0.455885026557204 2741 762596 SGTC_184 1494-0393 24.714 µM -0.110835138711108 0.448890099033026 no 1865 0.455873540171285 2587 3090647 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.11171423838476 0.448534173267609 no 1866 0.455524994702219 2619 65057 A dermal irritant. YDR527W RBA50 SGTC_3355 9151058 44.0485 µM -0.11215963350469 0.448353859565098 no 1867 0.455348417476886 2598 17015728 SGTC_2186 6124449 200 µM -0.112231499827488 0.448324766210982 no 1868 0.455319926845512 2694 3834182 YLR033W RSC58 SGTC_446 go6976 132 µM -0.112385498418218 0.448262424517579 no 1869 0.455258876533115 2655 3501 A protein kinase C inhibitor. SGTC_2874 9043904 71.43 µM -0.11356357979756 0.447785556122211 no 1870 0.454791879814595 2693 4463428 SGTC_1478 0453-0656 35.7 µM -0.113786952870854 0.447695146783598 no 1871 0.454703340757332 2613 5258496 SGTC_2275 7947463 200 µM -0.114256045105727 0.447505292469124 no 1872 0.454517412586913 2580 1225414 SGTC_606 k015-0008 38.6 µM -0.114677381684054 0.447334776411745 no 1873 0.454350421217154 2685 1970475 SGTC_564 3555-0129 330 µM -0.114957830872649 0.447221283257417 no 1874 0.454239273235117 2608 563260 SGTC_1706 st031321 9.9705 µM -0.116574618084669 0.446567080736163 no 1875 0.453598576196459 2681 6103185 SGTC_1 0258-0098 57.368 µM -0.117068689542367 0.446367192940579 no 1876 0.453402810608182 2649 6790032 YDR047W HEM12 SGTC_2709 st078560 56 µM -0.118110026332263 0.445945941253141 no 1877 0.452990239598627 2663 17250903 SGTC_1136 pergolide 1.05886 µM -0.119031398047399 0.445573269858642 no 1878 0.45262524028272 2635 47811 A dopamine receptor agonist. SGTC_1785 bathophenanthroline 24 µM -0.119185656082012 0.445510881102421 no 1879 0.452564135215565 2632 72812 An iron chelator. SGTC_1884 5633444 25 µM -0.119417540625118 0.445417099299934 no 1880 0.452472282661548 2739 5724239 SGTC_2564 betulinic acid 100 µM -0.120584903214463 0.444945025636406 no 1881 0.452009913533594 2747 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_551 k048-0028 34.9 µM -0.122730894668148 0.444077405122997 no 1882 0.451160099198516 2735 6836383 SGTC_3008 9078912 71.4286 µM -0.123526143511768 0.443755955256978 no 1883 0.450845236646355 2649 16648731 SGTC_2255 7941087 197.44 µM -0.125489139585839 0.442962645691802 no 1884 0.450068161214432 2701 935561 SGTC_2429 5902844 64.44 µM -0.125739365543372 0.442861537731552 no 1885 0.449969119973963 2768 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1055 3448-0672 86 µM -0.126320110458776 0.4426268924387 no 1886 0.449739268962696 2763 748378 SGTC_649 1123-0311 367 µM -0.126332414929095 0.442621921134252 no 1887 0.449734399201299 2704 693629 YIL048W NEO1 SGTC_1909 st060837 51.5 µM -0.127143038480809 0.442294429497964 no 1888 0.449413594034255 2682 678937 SGTC_3182 9108849 49.47 µM -0.127336137597055 0.442216423328371 no 1889 0.449337179713607 2700 17133045 SGTC_1743 st037606 46.3785 µM -0.127876205125986 0.441998264379153 no 1890 0.449123470992258 2671 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_693 4161-2696 114 µM -0.129662318845098 0.441276893786034 no 1891 0.448416798016736 2752 805759 SGTC_2263 7948595 193.29 µM -0.13000600874244 0.44113810754678 no 1892 0.44828083637546 2632 2971371 SGTC_1704 st028805 70.8 µM -0.130595033350038 0.440900268930143 no 1893 0.44804783594499 2673 2876101 SGTC_577 r071-0003 38.6 µM -0.131330529689961 0.44060331732999 no 1894 0.447756920870805 2646 4568517 YMR134W ERG29 SGTC_572 0960-0087 17.7 µM -0.131523903771332 0.440525249409749 no 1895 0.447680439173065 2637 6796365 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.131809834895154 0.440409819106588 no 1896 0.447567353654128 2699 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2330 7979373 200 µM -0.132313765035025 0.440206395003177 no 1897 0.447368060088072 2679 1863007 SGTC_2449 5812982 45.77 µM -0.132348798020109 0.440192253641778 no 1898 0.447354205786997 2645 776185 SGTC_5 0352-0601 109.883 µM -0.133097221437408 0.439890164438128 no 1899 0.44705824628454 2647 762456 SGTC_748 act1.228 77.9 µM -0.135695647193553 0.438841623970721 no 1900 0.446030944464391 2648 4421505 YNR035C ARC35 SGTC_2384 9036245 200 µM -0.137796671346171 0.437994112896699 no 1901 0.445200557572643 2719 6462766 SGTC_64 000l-0018 272.079 µM -0.138203013046526 0.437830235483733 no 1902 0.4450399869417 2648 6811119 SGTC_1235 benzylparaben 21.5 µM -0.138888100856682 0.437553964055218 no 1903 0.444769286986265 2733 7180 SGTC_2984 9022109 38.96 µM -0.143628716753342 0.435643084368212 no 1904 0.442896831538279 2630 6459207 SGTC_3319 9138450 16.7555 µM -0.143762544687707 0.435589161679435 no 1905 0.442843990287425 2685 2029690 SGTC_2493 resveratrol 26.09 µM -0.144011217028445 0.435488968430271 no 1906 0.44274580603146 2633 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3303 9125618 40.5795 µM -0.144256438886815 0.43539016947954 no 1907 0.442648987585912 2762 22695467 SGTC_292 k038-0015 474 µM -0.14527340054051 0.434980482621734 no 1908 0.442247507604101 2776 46368540 SGTC_1010 4112-3296 15.2 µM -0.145375076396827 0.43493952594817 no 1909 0.442207370878199 2803 704384 SGTC_2139 5578692 56.4705 µM -0.145460856795385 0.434904972764058 no 1910 0.442173509374015 2688 650991 YMR113W FOL3 SGTC_1569 carminic acid 40.6 µM -0.145637453618945 0.434833839400599 no 1911 0.442103799742842 2732 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2724 maprotiline 69.64 µM -0.145791765732829 0.434771684065471 no 1912 0.442042888220549 2685 4011 A tricyclic antidepressant. SGTC_1399 3562-5772 25 µM -0.145900284146045 0.434727974928134 no 1913 0.442000053637116 2645 23847490 SGTC_191 3914-0123 66.505 µM -0.146407137141289 0.434523834827176 no 1914 0.441799996699504 2665 3144412 SGTC_2469 5655019 90.81 µM -0.146736310996434 0.434391266119102 no 1915 0.44167007838883 2828 2788239 SGTC_1200 1643-0193 18.4 µM -0.148695223817984 0.433602503137511 no 1916 0.440897065090576 2649 5403974 SGTC_1623 st003709 20.3 µM -0.148839061172267 0.433544596912501 no 1917 0.440840313776496 2659 16192618 SGTC_1562 morin hydrate 59.1 µM -0.149314398038609 0.433353245345047 no 1918 0.44065277731892 2847 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1840 st055363 71 µM -0.152508967638833 0.432067647159237 no 1919 0.439392759010196 2719 676033 SGTC_3142 9086498 49.47 µM -0.158401658957638 0.429698133529237 no 1920 0.43707015331197 2802 25236367 SGTC_1271 0832-2808 169 µM -0.158634257472612 0.429604654552428 no 1921 0.436978518490301 2818 3663794 SGTC_1781 st038725 66.3 µM -0.158702864112699 0.429577082995265 no 1922 0.436951490772225 2670 4270275 YIL048W NEO1 SGTC_3193 9111931 49.47 µM -0.160897947419666 0.428695107485407 no 1923 0.436086889482301 2701 17087244 SGTC_1984 st072354 53.1 µM -0.161101828009404 0.428613207096305 no 1924 0.436006600254605 2692 5762938 SGTC_2829 7992743 58.44 µM -0.161210228397261 0.428569663084612 no 1925 0.435963912696409 2868 16462845 SGTC_2963 9082507 9 µM -0.161894301206777 0.428294893792394 no 1926 0.435694545298486 2825 16459611 SGTC_2859 9028643 45.46 µM -0.162444787661532 0.428073806928834 no 1927 0.435477801864009 2798 17151580 SGTC_207 4185-0010 4.486 µM -0.16249290120446 0.428054484596451 no 1928 0.435458859003635 2721 3761753 SGTC_1981 st071826 47 µM -0.162649547741715 0.427991576758819 no 1929 0.43539718646972 2799 11838600 SGTC_2253 7938677 135.83 µM -0.162938626028702 0.427875490330252 no 1930 0.435283379012729 2906 2301972 SGTC_1195 1502-0147 41.1 µM -0.163319297507365 0.427722631948634 no 1931 0.435133520339084 2692 817940 SGTC_2208 7283366 200 µM -0.163337135839485 0.427715469244012 no 1932 0.435126498163759 2701 898663 SGTC_667 1498-1044 59 µM -0.163603224665763 0.427608628246558 no 1933 0.435021752998738 2724 6739982 SGTC_3260 9137109 49.47 µM -0.164026930342924 0.427438511290944 no 1934 0.434854971789979 2792 17478346 SGTC_1851 st056236 18.9 µM -0.164848710782795 0.427108606622502 no 1935 0.434531531411467 2713 5393171 SGTC_1910 st062352 60.4 µM -0.164878064073593 0.427096823652898 no 1936 0.434519979208394 2664 2245730 SGTC_1726 st035556 14.5795 µM -0.165437643587028 0.426872210236744 no 1937 0.434299763286412 2925 5919439 SGTC_2229 7354935 190 µM -0.165511281106924 0.426842654136968 no 1938 0.434270785624776 2717 318112 SGTC_126 0417-1624 672.48 µM -0.165527791608773 0.426836027326477 no 1939 0.434264288499834 2701 41912 YDL195W SEC31 SGTC_1259 0671-0132 43 µM -0.165940476201264 0.426670395066076 no 1940 0.434101896825345 2730 X1259 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.167257299569357 0.426141970455364 no 1941 0.433583800398205 2785 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3227 9130768 49.47 µM -0.168284977318013 0.425729668394565 no 1942 0.433179545841908 2720 17720899 SGTC_1545 lovastatin 49.4 µM -0.168792453874924 0.425526099828698 no 1943 0.432979947047541 2747 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3034 9090421 49.47 µM -0.169046398716214 0.425424240133997 no 1944 0.432880072820873 2673 17173761 SGTC_1384 3089-0840 101 µM -0.170247841646043 0.42494239752126 no 1945 0.432407614331151 2781 1069836 SGTC_582 0987-0078 156 µM -0.170354307096878 0.424899704601565 no 1946 0.432365752236065 2721 1625765 SGTC_779 1360-0071 233 µM -0.170380984295316 0.424889007114348 no 1947 0.432355262910692 2916 7566 SGTC_1263 0774-1208 64.8 µM -0.170799152673049 0.424721329915916 no 1948 0.432190847676629 2808 906585 SGTC_2740 felodipine 17.08 µM -0.17083493128876 0.424706984035088 no 1949 0.432176780803295 2809 3333 L-type calcium channel blocker SGTC_338 4055-0136 114 µM -0.172596019781593 0.424000977339555 no 1950 0.431484490349959 2709 2900563 SGTC_179 1273-0063 6.77 µM -0.172755592327465 0.42393701796014 no 1951 0.43142177215159 2726 3108139 SGTC_1388 3346-4487 254 µM -0.17332424528041 0.423709108527065 no 1952 0.431198283559534 2789 3345614 SGTC_1392 3455-1037 33.9 µM -0.173500117969337 0.423638625979395 no 1953 0.43112916758057 2854 981132 SGTC_2145 5634607 200 µM -0.176067656673832 0.422609941266251 no 1954 0.430120395091489 2711 308662 SGTC_1610 st001799 48.1 µM -0.176564760402371 0.422410837334506 no 1955 0.429925138125029 2706 621897 SGTC_627 1391-0720 175 µM -0.176796494180107 0.42231802825367 no 1956 0.429834121457845 2807 997839 SGTC_2104 5389443 200 µM -0.177324351507021 0.422106638180358 no 1957 0.429626812072653 2882 2244536 SGTC_934 2950-0684 338 µM -0.177426918138501 0.422065566107737 no 1958 0.429586532556365 2939 1121253 SGTC_2319 6033012 152.6 µM -0.17751574045218 0.422029998533496 no 1959 0.429551651240329 2738 847246 SGTC_2133 5320837 200 µM -0.178689323897386 0.421560114317728 no 1960 0.429090826279684 2862 2841355 SGTC_578 3460-0051 92 µM -0.179061967837812 0.421410936915707 no 1961 0.428944522287796 2715 2876744 SGTC_1885 st057546 99.9 µM -0.179527531158815 0.421224577734168 no 1962 0.428761750873501 2872 702008 SGTC_1760 st045453 10.4495 µM -0.179644503241854 0.421177758042782 no 1963 0.428715832230634 2788 3323419 YIL048W NEO1 SGTC_971 1315-0384 26.7 µM -0.18223682648328 0.420140432105747 no 1964 0.427698436749401 2764 6769120 SGTC_2294 7971431 200 µM -0.183026115702014 0.419824705435516 no 1965 0.427388763678208 2856 5741572 SGTC_1305 1181-0477 144 µM -0.184424633199366 0.419265405805994 no 1966 0.42684017337352 2874 6252086 SGTC_1308 1187-1617 41.4 µM -0.184467143822244 0.419248407368981 no 1967 0.426823500128859 2702 2882570 SGTC_955 1216-0110 33 µM -0.18468706003876 0.419160473357054 no 1968 0.426737248085101 2700 3619719 SGTC_995 3931-2021 34.6 µM -0.184879184120024 0.419083655399669 no 1969 0.426661899097873 2839 730143 SGTC_1747 st037496 66.6 µM -0.185454305783823 0.418853720001775 no 1970 0.426436358607865 2744 723305 SGTC_1564 D-Arginine 115 µM -0.185543074957461 0.418818232282289 no 1971 0.426401548909715 2767 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_109 0132-0036 33.701 µM -0.186135694478713 0.418581334598523 no 1972 0.426169175433052 2701 67274 A color developer. SGTC_90 0870-0863 4.608 µM -0.186235145122894 0.418541582424948 no 1973 0.42613018210937 2720 1738164 SGTC_438 sphingosine 6.67 µM -0.186334363990694 0.418501923725449 no 1974 0.426091280381911 2739 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1415 3966-0071 78.1 µM -0.189277789494077 0.417325787831464 no 1975 0.424937551044486 2753 2893185 SGTC_1594 piperine 70.1 µM -0.189473857911697 0.41724746883385 no 1976 0.424860721171802 2745 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2027 5150920 200 µM -0.18953230563307 0.417224122685192 no 1977 0.424837818846188 2820 786715 SGTC_1838 st055369 84.5 µM -0.189804152678891 0.41711554091072 no 1978 0.424731300842259 2719 676036 SGTC_2138 5575593 77.673 µM -0.19070072886233 0.416757473230274 no 1979 0.424380033810988 2740 762213 SGTC_343 4130-2827 29.8 µM -0.190762211821605 0.416732921166831 no 1980 0.424355947774561 2791 1118244 SGTC_2055 5235184 200 µM -0.191351677857082 0.41649754549012 no 1981 0.42412503797013 2896 2836034 SGTC_177 1327-0068 8.361 µM -0.192470515432663 0.416050872465673 no 1982 0.423686830695396 2727 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_613 3914-0030 117 µM -0.192577754353297 0.416008065204049 no 1983 0.4236448341256 2693 1145395 SGTC_2761 levamisole 97.89 µM -0.192689318858819 0.41596353232797 no 1984 0.423601144504299 2863 26879 An alkaline phosphatase inhibitor. SGTC_1669 st015249 58.4 µM -0.193255312356768 0.415737622999784 no 1985 0.423379511055201 2825 722793 SGTC_1329 1447-1697 50.6 µM -0.194137816715119 0.41538543784358 no 1986 0.423033985715221 2862 2840515 SGTC_1515 3460-0031 42.1 µM -0.194191328288795 0.415364084911531 no 1987 0.423013036326101 2773 2876596 SGTC_169 k015-0017 16.025 µM -0.195495769108899 0.414843646260616 no 1988 0.422502424772557 2899 1840002 SGTC_1442 4112-3290 3 µM -0.196340361020896 0.414506755242832 no 1989 0.422171886299743 2746 704353 SGTC_1792 st045773 43.6 µM -0.197509793051733 0.414040395779018 no 1990 0.421714309318654 2740 2919270 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.197786149640152 0.413930204820943 no 1991 0.421606191545807 2737 4620898 SGTC_2638 epoxomicin 18 µM -0.197819919743458 0.41391674021816 no 1992 0.421592980221815 2861 9915668 A protesome inhibitor. SGTC_2983 9022671 12.99 µM -0.198691127022735 0.413569412966411 no 1993 0.421252182627096 2965 6405161 SGTC_1581 himbacine 57.9 µM -0.199246291473632 0.413348118868339 no 1994 0.421035044960946 2755 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1880 MG-132 525 µM -0.201565681561933 0.412423885281702 no 1995 0.420128138323681 2863 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_759 3486-0358 89.3 µM -0.201680918757592 0.412377978029462 no 1996 0.420083090347292 2870 875103 SGTC_2803 7707263 71.43 µM -0.20197196445371 0.412262038962043 no 1997 0.419969320810702 2790 2199229 SGTC_2518 prenyletin 46.28 µM -0.202331613035881 0.412118782272993 no 1998 0.419828743698033 2863 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2708 st078559 56 µM -0.20233178322562 0.412118714485093 no 1999 0.419828677177788 2800 17250902 SGTC_2289 7946404 165.07 µM -0.202898061796752 0.411893175846018 no 2000 0.419607354618249 2775 1246120 YPR165W RHO1 SGTC_3312 9133330 71.43 µM -0.203029125122483 0.411840979809237 no 2001 0.419556133855878 2916 17617324 SGTC_2356 9061756 188.97 µM -0.203166229362407 0.411786379644595 no 2002 0.419502553706897 2843 20104043 SGTC_220 paclitaxel 373.376 µM -0.203340259941822 0.411717076455887 no 2003 0.419434544944721 2871 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_453 enantio-paf c16 10 µM -0.203380775293143 0.411700942657531 no 2004 0.419418712446708 2874 13871343 A lipid and platelet activating factor SGTC_120 rhodamine 6G 52.259 µM -0.203718712962151 0.411566376812508 no 2005 0.419286659007873 2755 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1458 k015-0034 6.33 µM -0.204789086871908 0.411140225601648 no 2006 0.418868456866255 2820 3598957 SGTC_314 1671-0008 2.74 µM -0.205307533420316 0.410933852560871 no 2007 0.418665929304487 2756 3913060 SGTC_2478 5763493 32.33 µM -0.205727087150513 0.410766862877618 no 2008 0.418502049316958 2755 1365576 YLR208W SEC13 SGTC_395 anisomycin 6.25 µM -0.205936523358715 0.410683509672901 no 2009 0.418420247676611 2830 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_848 0368-0089 85.6 µM -0.208828247683909 0.409533050514595 no 2010 0.417291159500757 2890 762535 SGTC_175 3793-3120 23.7 µM -0.210052518604893 0.4090462139994 no 2011 0.416813341671604 2797 5322297 SGTC_727 3032-0951 202 µM -0.210302591459769 0.408946788697676 no 2012 0.416715756411656 2851 3652836 SGTC_515 4092-1064 102 µM -0.212419378864975 0.40810542034087 no 2013 0.415889934291992 3007 717353 SGTC_755 1995-0008 37.3 µM -0.212687221762397 0.407998989808296 no 2014 0.415785467147396 2781 689533 SGTC_1360 1598-0022 39.8 µM -0.213957215643445 0.407494435295426 no 2015 0.41529021076163 2887 761525 SGTC_3183 9108214 49.47 µM -0.214504226439916 0.407277161183486 no 2016 0.415076935723022 2831 4974831 SGTC_310 1273-0058 1.06 µM -0.215994013491084 0.406685558717522 no 2017 0.414496206986693 2885 2734232 SGTC_2960 9079389 5.97 µM -0.216004443210532 0.406681417768628 no 2018 0.414492142070997 2943 16457355 SGTC_2842 9000675 19.48 µM -0.216056653225487 0.40666068879613 no 2019 0.414471793693036 2848 2989072 SGTC_2683 piperine 63.03 µM -0.216088944051328 0.406647868481723 no 2020 0.414459208752548 2810 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1237 0330-0133 46.1 µM -0.21627817622261 0.406572740301789 no 2021 0.414385459675526 2786 X1237 YHR072W ERG7 SGTC_563 tetrahydrosecaminediol 614 µM -0.216359327318647 0.406540523080122 no 2022 0.414353833745152 2937 334274 A psychoactive constituent of the cannabis plant. SGTC_715 0868-0130 184 µM -0.218039105157136 0.405873788766445 no 2023 0.413699321411433 2944 2876258 SGTC_1995 st072814 61.1 µM -0.219298423467787 0.405374121365051 no 2024 0.41320879495272 2819 5769371 SGTC_1175 0741-0056 27.6 µM -0.220167867875938 0.40502923652576 no 2025 0.412870210177258 2996 765927 SGTC_1154 4088-0362 150 µM -0.220359045607751 0.404953411424998 no 2026 0.412795769167337 2769 6618304 SGTC_328 k915-0120 63.5 µM -0.220893838732669 0.404741320208614 no 2027 0.412587547456046 2922 6624543 SGTC_1413 3910-0535 34.4 µM -0.22174230024989 0.40440489008378 no 2028 0.412257249440587 2915 2876951 SGTC_2348 9022543 33.42 µM -0.223224908279978 0.403817179341463 no 2029 0.411680233495216 2935 3162678 YDL140C RPO21 SGTC_2060 5238662 140 µM -0.223476787089706 0.403717355281629 no 2030 0.41158222376891 2903 790130 SGTC_42 0133-0086 60.653 µM -0.224175935874097 0.403440303044246 no 2031 0.411310203685349 2752 162923 Model of phenazepam hydroxylation. SGTC_2389 9091542 195.52 µM -0.224971817274617 0.403124977475372 no 2032 0.411000599422927 2863 3626624 YOL127W RPL25 SGTC_1904 st060225 78 µM -0.225001711398181 0.403113134748905 no 2033 0.410988971447499 2806 66595 SGTC_1290 0986-0249 10.2 µM -0.227796521823394 0.402006348707326 no 2034 0.409902215399676 2874 53329 SGTC_2727 riluzole 51.77 µM -0.228160220841371 0.4018623761078 no 2035 0.409760842504715 2800 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1294 1000-1494 117 µM -0.228841682307918 0.401592651062095 no 2036 0.409495984245119 2826 712797 YDL207W GLE1 SGTC_213 1246-0773 967 nM -0.229409819186567 0.401367816145291 no 2037 0.409275202524826 2846 6251622 SGTC_1619 st003326 88.7 µM -0.229446180628187 0.40135342755197 no 2038 0.409261073208934 2978 2849032 SGTC_31 0508-1974 57.237 µM -0.230167033677915 0.401068206284256 no 2039 0.408980988746305 2913 6810525 SGTC_1361 1608-0041 5.61 µM -0.233396944295157 0.399790870914425 no 2040 0.407726592881032 2835 X1361 SGTC_1380 2291-0730 164 µM -0.234841600162589 0.399219897702809 no 2041 0.40716583911696 2914 2999191 SGTC_790 1575-0012 79.1 µM -0.235020124885794 0.399149354083309 no 2042 0.407096556619843 2995 378741 YLR208W SEC13 SGTC_2807 7945238 51.95 µM -0.235950329406653 0.398781839317302 no 2043 0.406735606685202 2930 17148797 SGTC_3176 9106582 49.47 µM -0.236494024714669 0.398567072112731 no 2044 0.40652467169323 2882 17018027 SGTC_2017 5132927 60.65 µM -0.237340745906853 0.398232666657344 no 2045 0.406196227156945 2830 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_468 gf-109203x 121 µM -0.237462798886113 0.398184469010389 no 2046 0.406148888043707 2905 2396 A protein kinase C inhibitor. SGTC_2798 7813637 45.45 µM -0.239084187093419 0.397544344740977 no 2047 0.405520151566274 2966 956368 SGTC_485 niflumic acid 177 µM -0.24054310018527 0.396968601333182 no 2048 0.404954627376134 2946 4488 A COX2 inhibitor. SGTC_2245 6637752 200 µM -0.242148134196246 0.396335452343653 no 2049 0.404332691037387 2995 681890 SGTC_1872 amphotericin b 148 nM -0.242790090773298 0.396082291665602 no 2050 0.404084006175549 2964 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2738 aclarubicin 5.55 µM -0.243512942283524 0.395797281882891 no 2051 0.403804030160955 2914 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2806 7952793 58.44 µM -0.24364731731917 0.395744305906552 no 2052 0.403751989232721 2988 2972490 SGTC_2691 st077356 60.2 µM -0.243916215871954 0.395638301200547 no 2053 0.403647854989146 3000 2839272 SGTC_1240 0356-0016 42.1 µM -0.245196352368533 0.395133754064884 no 2054 0.4031522002947 2887 4305613 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.245201999837572 0.395131528586118 no 2055 0.403150014001218 2883 4330530 SGTC_3322 9139058 2.11 µM -0.245592705492103 0.394977572856555 no 2056 0.402998768250022 3018 4908926 YPR165W RHO1 SGTC_1324 1418-0026 34.4 µM -0.245958885911835 0.394833296064318 no 2057 0.402857029616486 2947 1372513 SGTC_2700 st077718 96.8 µM -0.246503696742693 0.394618664751587 no 2058 0.402646171564891 2888 904970 SGTC_3127 9126946 49.47 µM -0.24778751576459 0.3941130235708 no 2059 0.402149407371957 2923 27243249 SGTC_476 mead acid 10 µM -0.248459669125977 0.393848362331503 no 2060 0.401889385611546 2843 5312531 An omega 9 fatty acid. SGTC_1965 Pectolinarigenin 58.4 µM -0.249561773586746 0.393414513439139 no 2061 0.401463131776021 2848 5320438 An anti-inflammatory. SGTC_2401 5128683 200 µM -0.250038485601101 0.393226894348578 no 2062 0.401278793233767 2879 708373 SGTC_1183 1254-0324 198 µM -0.255593405889631 0.391042488331424 no 2063 0.399132405327822 3003 5799357 SGTC_3082 9117008 49.47 µM -0.256018938676376 0.39087529334488 no 2064 0.398968106800685 2890 41448529 SGTC_1210 3013-0140 750 nM -0.256724294769038 0.390598198145633 no 2065 0.398695807722123 3001 905973 SGTC_843 0310-0051 143 µM -0.257223897201353 0.390401965721519 no 2066 0.398502968603148 2896 2065037 SGTC_772 k072-0172 35.3 µM -0.257406243544649 0.39033035119412 no 2067 0.398432591793069 2886 5861980 SGTC_1001 4048-4355 44.4 µM -0.25939813655663 0.389548299879648 no 2068 0.397664033668076 2866 21824233 SGTC_1571 st070080 73.4 µM -0.260947392533151 0.388940344344559 no 2069 0.397066538307307 3008 4315245 SGTC_3184 9108758 49.47 µM -0.261278239880074 0.388810549150313 no 2070 0.396938972981506 2808 902885 SGTC_136 0097-0015 404.482 µM -0.262311986598134 0.38840507853197 no 2071 0.396540460764116 2862 4861337 SGTC_677 0929-0063 136 µM -0.26404159467075 0.387726939513137 no 2072 0.395873933894425 2880 1539583 SGTC_1190 1486-1332 13 µM -0.265669903084159 0.387088830505542 no 2073 0.395246722239107 2898 4150046 SGTC_879 0831-1030 162 µM -0.265708942364362 0.387073535349859 no 2074 0.395231687937623 2891 1549252 SGTC_1902 st060212 70.5 µM -0.266028171857446 0.386948471366896 no 2075 0.395108756267174 2891 688944 SGTC_2617 dihydrotanshinone i 20.83 µM -0.266096800217518 0.386921586486073 no 2076 0.3950823296242 2877 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2012 4023501 200 µM -0.266754888637128 0.386663810588658 no 2077 0.394828944798488 2959 3477460 SGTC_2760 etidronate 98.04 µM -0.267972703539016 0.386186919507419 no 2078 0.394360164984932 2897 3305 A chelator and antioxidant. SGTC_3252 9135871 49.47 µM -0.268137287015983 0.386122482495061 no 2079 0.39429682273096 3018 17682838 SGTC_1436 4092-1007 8.32 µM -0.268647160410503 0.385922879011304 no 2080 0.394100608571559 2902 2881121 SGTC_1192 1488-0095 21.4 µM -0.268835817809048 0.385849031712342 no 2081 0.394028014509008 2957 915875 SGTC_3204 9114183 49.47 µM -0.269808833477048 0.385468224084851 no 2082 0.393653663322758 2827 17027248 SGTC_1708 st033234 31.827 µM -0.270657857214105 0.385136033153847 no 2083 0.393327096185978 3008 674664 SGTC_2780 5215298 71.43 µM -0.270781177316151 0.385087789657973 no 2084 0.393279668774242 3029 2834131 SGTC_528 3492-0019 172 µM -0.271230253929703 0.384912123476561 no 2085 0.393106972758452 2953 2869262 SGTC_702 1488-0190 94 µM -0.271913387909768 0.384644945920697 no 2086 0.392844308449196 2977 949357 SGTC_1824 st053723 68.6 µM -0.273754050773103 0.383925325257501 no 2087 0.392136818619468 2937 675225 SGTC_2786 7743617 45.45 µM -0.276378604852309 0.382899928961195 no 2088 0.391128643921432 2936 583674 SGTC_605 1315-0399 119 µM -0.276536416305417 0.382838299116175 no 2089 0.391068046758605 3025 24020461 SGTC_2765 myclobutanil 7.74 µM -0.278168501019001 0.382201098015631 no 2090 0.390441506762285 3007 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1805 st050013 60.3 µM -0.278323720252482 0.382140513656627 no 2091 0.390381934531208 2951 4037144 SGTC_669 0108-0021 26.2 µM -0.27873334067998 0.381980646614027 no 2092 0.390224736975097 3057 17201 SGTC_61 0978-8327 98.565 µM -0.279126635144354 0.381827170217916 no 2093 0.390073821623181 2978 6150059 YHR072W ERG7 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.27927024949861 0.381771131815703 no 2094 0.390018717905108 2923 688664 SGTC_2998 9066762 71.4286 µM -0.279892519092089 0.381528350506979 no 2095 0.389779983417097 3070 4945196 SGTC_1339 1486-1321 22.7 µM -0.28014533182711 0.381429727777881 no 2096 0.389683003375373 2920 3469382 SGTC_59 0330-0160 1.33 µM -0.281401918176801 0.380939645394583 no 2097 0.389201073523002 2934 4293482 SGTC_128 0906-2981 13.371 µM -0.282291974332298 0.380592629252473 no 2098 0.388859819497541 3068 6740226 SGTC_1718 roemerine 11.9335 µM -0.283193977481631 0.380241053195084 no 2099 0.388514072373683 3060 235224 An aporphine alkaloid with mutagenic activity. SGTC_1495 4469-0029 237 µM -0.283647424665151 0.380064349280503 no 2100 0.388340294723302 2887 793680 SGTC_2869 9037858 32.47 µM -0.284165618791126 0.379862444769589 no 2101 0.388141731027841 2873 27187042 SGTC_968 1309-0633 340 µM -0.284674937458036 0.379664030319385 no 2102 0.387946596756055 3003 3761976 SGTC_205 1486-1330 71.903 µM -0.285241429951478 0.37944337997007 no 2103 0.387729590821597 2900 4118834 SGTC_1968 st069590 43.6 µM -0.285268393677194 0.379432878504662 no 2104 0.387719262717268 3061 6384066 SGTC_1406 3909-7906 11.9 µM -0.285664426760247 0.379278647173695 no 2105 0.387567576553257 2952 X1406 SGTC_786 4544-0069 423 µM -0.285743628955081 0.379247804934046 no 2106 0.387537243072384 3022 748821 YLR208W SEC13 SGTC_1300 1094-0077 113 µM -0.286449550891905 0.378972944839779 no 2107 0.387266913871548 2917 5532636 SGTC_1217 1183-1422 255 µM -0.286746196146589 0.378857460315165 no 2108 0.387153331389269 3045 2849664 SGTC_633 0437-0093 97.7 µM -0.289293795792645 0.377866121480444 no 2109 0.386178279841285 2920 2831118 SGTC_1679 SEC14.276 6.7 µM -0.289737701528655 0.377693467990137 no 2110 0.386008455603214 3045 1005053 YMR079W SEC14 SGTC_1985 st071382 65.5 µM -0.289971564766266 0.377602518629192 no 2111 0.385918995737191 2931 6123237 SGTC_2772 vinpocetine 57.06 µM -0.290087854020444 0.377557296290051 no 2112 0.385874513786345 3119 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1219 1469-0211 33.1 µM -0.29038242212763 0.377442752729269 no 2113 0.385761844879941 3027 6822282 SGTC_1649 st011737 51.3 µM -0.290424213722845 0.377426502833665 no 2114 0.385745860856778 2969 1761035 SGTC_2212 7123476 200 µM -0.291627439505595 0.376958743715483 no 2115 0.38528574663027 2943 1085715 SGTC_2451 5856223 45.7 µM -0.292119860488381 0.376767364991695 no 2116 0.385097491079865 2948 2179896 SGTC_1947 st076332 61.6 µM -0.292351723910569 0.376677262080204 no 2117 0.385008857651083 3012 24208416 SGTC_1395 3486-0190 4.35 µM -0.294146951709811 0.375979858178058 no 2118 0.384322807344999 3082 6748079 SGTC_1777 st045864 34.765 µM -0.294520996617686 0.375834601392507 no 2119 0.384179910774972 2979 4691462 SGTC_2311 7694451 200 µM -0.294960391035264 0.375663989219522 no 2120 0.384012068805908 2979 2163142 SGTC_166 k072-0058 166.424 µM -0.296365729355798 0.375118474674411 no 2121 0.383475397174988 3029 5846229 SGTC_2284 7945075 39.21 µM -0.296393394227296 0.375107738417815 no 2122 0.383464834733259 3067 1245402 SGTC_2108 5365811 200 µM -0.298370827051499 0.374340582167395 no 2123 0.382710076114848 3034 780283 SGTC_1491 4138-0063 26.5 µM -0.300029812623418 0.373697352754077 no 2124 0.382077207690576 3016 23883227 SGTC_151 3013-0144 2.285 µM -0.30058806220749 0.37348098467651 no 2125 0.381864317845707 3125 906558 YHR107C CDC12 SGTC_2597 laccaic acid a 100 µM -0.301908669525622 0.372969298525251 no 2126 0.381360843322736 3072 5491415 A textile dye. SGTC_1787 fluconazole 80 µM -0.304823036332742 0.371840883737137 no 2127 0.380250467760466 3018 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1457 k015-0032 57.3 µM -0.305448783394798 0.37159874362001 no 2128 0.380012186027516 2915 4302660 SGTC_1665 st014639 11.4 µM -0.306060295607053 0.371362160917223 no 2129 0.379779368859394 2976 981133 YIL048W NEO1 SGTC_1687 st020778 55.3625 µM -0.306123924806556 0.371337546752919 no 2130 0.379755146218901 2975 4259299 SGTC_398 bronopol 33.3 µM -0.307372728751228 0.370854569104416 no 2131 0.379279841710999 2921 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_102 gallobenzophenone 83.616 µM -0.307475841975672 0.370814698920573 no 2132 0.379240604158047 3119 70837 SGTC_1285 0929-0069 65.5 µM -0.307575653680444 0.37077610663705 no 2133 0.379202624113345 2970 1206237 SGTC_532 1548-0774 215 µM -0.308212429502465 0.370529927322818 no 2134 0.378960347586442 3161 5932993 SGTC_1754 st042065 16.137 µM -0.309206075915097 0.370145886762489 no 2135 0.378582386157757 2997 1126236 YIL048W NEO1 SGTC_1822 st052468 42 µM -0.30924506765739 0.370130819238945 no 2136 0.378567556914496 3003 2873678 SGTC_1643 st009866 20.2 µM -0.30932333187373 0.370100576310623 no 2137 0.37853779220044 3039 3156273 YOR207C RET1 SGTC_2939 9044578 71.43 µM -0.31012869742072 0.369789412924103 no 2138 0.3782315450031 2912 2653634 SGTC_1560 lithocholic acid 53.1 µM -0.310977141367709 0.369461697840291 no 2139 0.377908999602618 3011 9903 A bile acid which acts as a detergent. SGTC_1976 st070609 63.5 µM -0.311135394829809 0.369400582252823 no 2140 0.377848847198936 2887 682556 SGTC_2398 5228213 48.84 µM -0.311552791893247 0.369239404351754 no 2141 0.37769020809318 3168 80771 YMR134W ERG29 SGTC_1526 st051518 75 µM -0.31181474512796 0.369138262831189 no 2142 0.377590658686268 2997 673993 SGTC_1607 st000305 50.6 µM -0.31256937954956 0.368846945176413 no 2143 0.377303922401291 3102 5457690 SGTC_3006 9075424 71.4286 µM -0.314057203349606 0.368272809299095 no 2144 0.376738796484016 2994 7465181 SGTC_3197 9113331 49.47 µM -0.314441586488293 0.368124527550418 no 2145 0.376592837604877 3191 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1080 nisoldipine 24.4 µM -0.315052607648383 0.367888857117057 no 2146 0.376360855513651 2914 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.315484359345133 0.367722360764927 no 2147 0.376196962313285 3293 5282309 SGTC_2881 9058953 51.95 µM -0.315571744199355 0.367688665578023 no 2148 0.37616379368607 2922 17122249 SGTC_1423 4048-0112 5.59 µM -0.317475800969856 0.366954723539736 no 2149 0.37544129925441 3048 X1423 SGTC_2619 obliquin 87.91 µM -0.319671717150636 0.366108884279821 no 2150 0.374608601031472 2936 6708593 A bioactive alkalod. YER133W GLC7 SGTC_105 0111-0055 734.78 µM -0.320115531551625 0.36593801141779 no 2151 0.374440376101428 3052 5179370 SGTC_502 l-744,832 89.3 µM -0.3205112440066 0.365785680693713 no 2152 0.374290404050222 3080 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_99 0109-0120 622.8 µM -0.320907111560251 0.365633311435454 no 2153 0.37414039224876 3196 759414 SGTC_1477 0139-0234 16 µM -0.321041713158272 0.365581508163882 no 2154 0.374089390064066 2988 620880 SGTC_326 k292-0812 17.5 µM -0.321727756551601 0.36531751306146 no 2155 0.373829474127817 3058 3579357 SGTC_2232 chlorophetanol 41.5365 µM -0.321806178186553 0.365287339836893 no 2156 0.373799766782829 3054 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2549 cedrol 20.94 µM -0.322230794862462 0.36512398034559 no 2157 0.373638928351318 3134 6708665 A sedative which affects the nervous system. SGTC_2605 digitonin 300 nM -0.322516216409743 0.365014186072629 no 2158 0.373530827313416 3109 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3134 9127454 49.47 µM -0.322673622302508 0.364953640838292 no 2159 0.37347121539674 3076 24262820 SGTC_1789 tunicamycin 25 nM -0.323364658788218 0.364687877647019 no 2160 0.373209545600267 3093 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3324 9138759 60.749 µM -0.323889566509477 0.364486048748445 no 2161 0.373010821649304 3105 45595710 SGTC_3057 9095946 49.47 µM -0.326217690595505 0.363591330155874 no 2162 0.372129828858363 2935 24540043 SGTC_2764 methyldopa 94.69 µM -0.327468428581991 0.363110967200059 no 2163 0.371656809052228 3174 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1950 st077106 7.18 µM -0.328322137990916 0.362783212030311 no 2164 0.371334053689089 3067 13831864 SGTC_653 0203-0016 55.2 µM -0.329402568487689 0.36236855845548 no 2165 0.370925713326549 3024 295302 SGTC_1149 3909-7961 23.3 µM -0.33083406265772 0.361819420400938 no 2166 0.370384915021007 3013 735261 SGTC_1653 st012112 65 µM -0.331632000565367 0.361513445375149 no 2167 0.370083576415712 3157 720429 SGTC_1666 st014829 29 µM -0.332419657868795 0.361211499353721 no 2168 0.369786198441747 2946 3858230 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.333372403370447 0.36084638280902 no 2169 0.369426595901065 3053 77254 SGTC_1134 3477-0009 42.5 µM -0.334796778027727 0.360300762400505 no 2170 0.368889195579683 3234 3973534 SGTC_886 0866-0150 153 µM -0.335133416874285 0.360171851162298 no 2171 0.368762222976767 3163 271463 SGTC_2568 diosmetin 100 µM -0.335635375723311 0.359979662421464 no 2172 0.36857292199337 3164 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2540 epiandrosterone 100 µM -0.335727788248727 0.359944283602478 no 2173 0.36853807444 3011 441302 A steroid. SGTC_3143 9086658 49.47 µM -0.336320693447112 0.359717326847254 no 2174 0.368314523383879 3049 25236626 SGTC_1814 st052110 31.539 µM -0.338944806693433 0.358713443713237 no 2175 0.367325654663893 3143 674163 SGTC_1281 0884-0031 11.8 µM -0.339599992113873 0.358462947270966 no 2176 0.367078892036787 3026 1548255 SGTC_373 0844-0104 25.9 µM -0.340962764924858 0.357942114732347 no 2177 0.366565806574303 3143 5375804 SGTC_2910 7948405 25.97 µM -0.342759874897972 0.35725568887456 no 2178 0.365889557237129 3180 2971328 SGTC_2236 dapsone 200 µM -0.343910274316439 0.356816523411553 no 2179 0.365456882434396 3052 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3304 9125678 46.087 µM -0.344048870685267 0.35676362698223 no 2180 0.365404766727439 3004 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2357 9067248 200 µM -0.344155232883737 0.356723034853524 no 2181 0.365364773561356 3107 9150235 SGTC_2682 pyrogallin 40.03 µM -0.345014869560821 0.356395022217083 no 2182 0.365041596017893 3050 822798 An ATP competetive kinase inhibitor. SGTC_1818 st052136 56.3 µM -0.345274435975746 0.356296000002429 no 2183 0.364944031717415 3104 674169 SGTC_2907 7721985 69.9 µM -0.345666588674928 0.356146415710663 no 2184 0.364796648247895 3090 3267881 SGTC_3053 9095903 49.47 µM -0.346191908833377 0.355946070182467 no 2185 0.36459924751565 3084 17174018 SGTC_74 000s-0487 160.283 µM -0.346699584738669 0.355752491573734 no 2186 0.364408511111497 3036 677548 SGTC_1086 cerivastatin 2.18 µM -0.34701328506983 0.355632895121208 no 2187 0.364290669088323 3076 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3113 9123498 49.47 µM -0.347777191826495 0.355341719508273 no 2188 0.364003759984254 3072 8897275 SGTC_664 1222-0054 14.9 µM -0.348769305354195 0.354963685175958 no 2189 0.363631254467832 3047 6813991 SGTC_1085 doxorubicin 7.67 µM -0.348968207761176 0.354887912689678 no 2190 0.363556588750563 3123 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3120 9124077 49.47 µM -0.349764414736262 0.354584652684003 no 2191 0.363257753564306 3050 18774327 YGL155W CDC43 SGTC_3009 9080819 71.4286 µM -0.349902888509988 0.354531920074001 no 2192 0.363205789592815 3088 17027216 SGTC_730 1436-0052 41.2 µM -0.351591187967991 0.353889218220242 no 2193 0.362572437381313 3010 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_230 MPP+ 141.667 µM -0.351967707003659 0.353745941636705 no 2194 0.362431240437945 3066 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2657 nystatin 74.44 µM -0.35231079505419 0.353615404563323 no 2195 0.36230259661055 3078 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3229 9132204 49.47 µM -0.352499142017979 0.35354375021411 no 2196 0.362231980900017 3021 17682924 SGTC_2489 cantharidin 73.42 µM -0.353578104175386 0.353133372054242 no 2197 0.361827543007895 2996 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_431 k089-0097 107 µM -0.354299830588221 0.352858962094374 no 2198 0.361557097348402 3124 5499420 SGTC_2003 4023581 200 µM -0.3546107827163 0.352740757547723 no 2199 0.361440598527448 3162 16641307 SGTC_560 2332-1943 155 µM -0.354938838819569 0.352616066548817 no 2200 0.361317705593573 3024 21177716 SGTC_1018 4259-0013 28.1 µM -0.355287501586578 0.352483560510147 no 2201 0.361187108893126 3159 6801262 SGTC_2207 7258803 200 µM -0.356668990184937 0.351958714736382 no 2202 0.360669811450748 3112 3666799 SGTC_868 0527-0199 213 µM -0.358007705566277 0.351450388015767 no 2203 0.360168773515784 3056 2849450 SGTC_56 0957-0365 83.25 µM -0.358367471763678 0.351313825594243 no 2204 0.360034165541932 3165 6752360 SGTC_222 nsc-310342 10.666 µM -0.358474461412555 0.351273217460934 no 2205 0.359994138280328 3134 432556 SGTC_799 1310-0557 151 µM -0.35946562330844 0.350897100775111 no 2206 0.359623395105169 3191 5354492 SGTC_1510 1123-0200 71.5 µM -0.362262461813703 0.349836571681597 no 2207 0.358577953454135 3253 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_258 haloperidol 50.781 µM -0.362265530881403 0.34983540856776 no 2208 0.358576806835034 3079 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_663 1486-0733 13.9 µM -0.363497156354277 0.349368761583205 no 2209 0.358116768383755 3036 722445 YPR165W RHO1 SGTC_2025 5147754 141 µM -0.364089771789773 0.349144308303757 no 2210 0.357895487183129 3106 315777 YLR208W SEC13 SGTC_381 3461-2219 42.7 µM -0.364762292056247 0.348889654956472 no 2211 0.357644427540454 3146 2883159 SGTC_2745 rifampicin 24.3 µM -0.366733400387641 0.348143676757705 no 2212 0.356908944963277 3091 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1757 st041620 31.8375 µM -0.366795052150688 0.348120353720452 no 2213 0.356885949308055 3101 5289815 SGTC_2825 7998094 58.44 µM -0.368167401118769 0.347601339060922 no 2214 0.356374207969723 3091 2987815 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.368305822541292 0.347549004694209 no 2215 0.356322605724523 2992 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3086 9117350 49.47 µM -0.368534083971442 0.347462709967056 no 2216 0.356237517689259 3114 2679265 SGTC_1930 st074634 34.3 µM -0.370329273219237 0.346784310664491 no 2217 0.355568582489454 3021 684253 YOR116C RPO31 SGTC_2730 imipramine 71.33 µM -0.370555261229574 0.346698944883784 no 2218 0.355484404820265 3090 3696 A tricyclic antidepressant. SGTC_2904 7225135 42.03 µM -0.371555604727181 0.346321163923862 no 2219 0.355111874257824 3168 4446116 SGTC_86 0417-1630 471.922 µM -0.371710909163279 0.346262526708536 no 2220 0.355054050881907 3141 3634867 SGTC_389 tpck 16.7 µM -0.372371372872595 0.346013201194245 no 2221 0.35480818250881 3128 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_889 0919-1524 82.7 µM -0.372787438711665 0.345856170306525 no 2222 0.354653326258614 3121 3905452 SGTC_1264 0783-0040 158 µM -0.372896893940138 0.345814864296786 no 2223 0.354612591920742 2996 2855798 SGTC_2505 galangin 7.89 µM -0.373703344923305 0.345510583929347 no 2224 0.354312518232376 2990 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2742 clothiapine 36.27 µM -0.374889564977287 0.345063195072844 no 2225 0.353871300003274 3123 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1929 genistein trimethyl ether 50.5 µM -0.374894826923796 0.3450612109851 no 2226 0.353869343242569 3247 136420 SGTC_2414 st077232 92.9 µM -0.376205156547915 0.344567266290071 no 2227 0.353382191084813 3005 729801 SGTC_2653 dihydrofissinolide 100 µM -0.376873398407578 0.344315466331472 no 2228 0.3531338456373 3155 6857746 SGTC_1627 st003713 25.6 µM -0.37821786293139 0.34380906830515 no 2229 0.352634378332645 3153 16195070 YER133W GLC7 SGTC_2073 5212005 126 µM -0.378922403665701 0.343543811960425 no 2230 0.352372743457361 3068 691789 SGTC_958 1222-0007 33 µM -0.379799197918131 0.343213810546276 no 2231 0.352047238890517 3230 7312461 SGTC_878 0828-0289 13.7 µM -0.380516034124371 0.342944101760929 no 2232 0.35178119829462 3087 745350 YLR208W SEC13 SGTC_3206 9114350 49.47 µM -0.380580288091303 0.342919930186246 no 2233 0.351757355156188 3170 17087243 SGTC_916 4466-0038 42 nM -0.380944459897456 0.342782945254091 no 2234 0.351622230569049 3296 5722064 YGL116W CDC20 SGTC_1430 4049-0248 69.1 µM -0.381350495985002 0.34263023724509 no 2235 0.351471594498015 3179 22774488 SGTC_2642 cholecalciferol 100 µM -0.381380225010679 0.342619057326985 no 2236 0.35146056618847 3162 9821465 A vitamin D precursor, similar to steriods. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.382802676185191 0.342084290609579 no 2237 0.350933038529427 3055 16486 A toxic proline analog. SGTC_1047 2043-3044 82 µM -0.38378981887228 0.341713362966624 no 2238 0.350567117325315 3091 669592 SGTC_1752 st044819 83.042 µM -0.389251806899609 0.339663742207815 no 2239 0.348544941503737 3082 441209 YML126C ERG13 SGTC_1964 st076914 61 µM -0.390479306391872 0.339203769937368 no 2240 0.348091077190677 3106 24208661 SGTC_122 0236-0016 402.397 µM -0.391338888954208 0.338881807148276 no 2241 0.347773378519648 3128 6808838 SGTC_1540 guanosine 70.6 µM -0.392200567204536 0.338559177493375 no 2242 0.347455012533069 3138 6802 Guanosine is a purine nucleoside SGTC_2061 5245884 80.95 µM -0.39261539721502 0.338403899022438 no 2243 0.347301782807211 3075 573863 SGTC_2491 paeonol 100 µM -0.392975004820868 0.338269313539221 no 2244 0.347168971300462 3044 11092 Increases levels of cortical cytochrome oxidase. SGTC_1050 3232-1156 69.3 µM -0.393744220457365 0.337981498972255 no 2245 0.346884944984617 3134 700529 SGTC_165 k038-0023 64.381 µM -0.393945717108557 0.33790612135958 no 2246 0.346810558274568 3098 46368543 SGTC_91 0417-1751 58.384 µM -0.39418898995211 0.337815124407727 no 2247 0.346720756875807 3177 6795624 SGTC_1957 st077035 62.4 µM -0.395224605340861 0.33742785541936 no 2248 0.346338567662592 3213 705593 SGTC_1176 0848-0131 83.3 µM -0.396392686942973 0.336991257195811 no 2249 0.345907680090509 3167 6769040 SGTC_304 1310-0298 97 µM -0.396860009627465 0.336816645695819 no 2250 0.345735347681658 3161 1550234 SGTC_777 1315-0167 517 µM -0.397112357580367 0.336722372457888 no 2251 0.345642303788599 3165 4221767 SGTC_2522 biochanin a 4.94 µM -0.398186036922031 0.336321377439662 no 2252 0.345246528874763 3232 5280373 A possible chelator. SGTC_2756 carbadox 75.1 µM -0.400111403282848 0.335602762915677 no 2253 0.34453723280124 3124 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1841 st054148 70 µM -0.400751055670305 0.335364154960648 no 2254 0.344301708581539 3175 675442 SGTC_967 1306-0166 352 µM -0.401332620114473 0.33514727302968 no 2255 0.344087625115556 3253 4437607 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.401718734667352 0.335003310271094 no 2256 0.343945517571802 3179 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1319 1306-0155 43.7 µM -0.403260728103833 0.334428620097307 no 2257 0.343378214494122 3129 3122360 SGTC_2722 naftopidil 47.16 µM -0.404656797255807 0.333908649293097 no 2258 0.342864901452958 3223 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2415 st077333 57.7 µM -0.406388161296342 0.333264239539822 no 2259 0.342228708462523 3343 2766255 SGTC_226 1,3-diallylurea 8.28947 mM -0.407629887834855 0.332802374503157 no 2260 0.341772709150827 3191 74537 YKL182W FAS1 SGTC_813 k007-0158 173 µM -0.408096903401781 0.332628731826722 no 2261 0.341601266677905 3166 6523916 SGTC_643 k048-0106 28.4 µM -0.408759649766397 0.332382375436853 no 2262 0.341358027073756 3212 6763920 SGTC_2894 9048625 32.47 µM -0.410356234589372 0.331789189621714 no 2263 0.340772323001587 3300 4092861 SGTC_2005 4024620 188 µM -0.410932367644118 0.331575239912175 no 2264 0.3405610638226 3128 236743 SGTC_180 1486-1293 102.781 µM -0.411895215793373 0.331217804392719 no 2265 0.340208113790437 3299 4140536 SGTC_511 blebbistatin 171 µM -0.41198731106047 0.331183624165394 no 2266 0.340174361873378 3282 3476986 A myosin inhibitor. SGTC_55 0767-0285 6.563 µM -0.412133124419506 0.331129509887871 no 2267 0.340120925476906 3229 3116166 SGTC_1044 1222-0021 1.78 µM -0.412993667716717 0.330810216779932 no 2268 0.339805626571789 3190 4306703 SGTC_3344 9148862 3.898 µM -0.413891854996259 0.330477087610783 no 2269 0.339476654592155 3278 4905352 SGTC_1162 k048-0130 20.1 µM -0.414294427177945 0.330327820958217 no 2270 0.339329247320607 3123 6797406 SGTC_256 clotrimazole 625 nM -0.414421496197127 0.330280711614764 no 2271 0.339282724376945 3193 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2178 5812956 200 µM -0.414972599628526 0.330076427644387 no 2272 0.339080980865984 3109 5403383 SGTC_2511 berberine 10.47 µM -0.418019862281758 0.328947778842768 no 2273 0.33796629761057 3123 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_7 0192-1582 4.227 µM -0.419799373128297 0.328289401230737 no 2274 0.337316011442673 3166 252616 SGTC_2096 5468907 200 µM -0.420993244307275 0.327847995243363 no 2275 0.336880007499388 3233 759785 SGTC_2009 4012297 12.05 µM -0.421805052401046 0.327547985426642 no 2276 0.336583658800548 3221 45595307 SGTC_138 0850-0259 40.9225 µM -0.422516637371037 0.327285105363433 no 2277 0.336323979763867 3240 6813004 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.422828991970428 0.327169739581373 no 2278 0.336210016700736 3151 390807 SGTC_2773 thioridazine 9.09 µM -0.422881447208382 0.327150367259303 no 2279 0.336190879801015 3211 5452 An antipsychotic. SGTC_2045 5106652 78.05 µM -0.423407809677593 0.326956001339212 no 2280 0.335998873949269 3246 673349 SGTC_336 4111-0029 111 µM -0.423596736116825 0.326886249333901 no 2281 0.335929968028516 3171 3131175 SGTC_2544 sphondin 68.51 µM -0.425306445951389 0.326255296458705 no 2282 0.335306647587512 3316 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1074 carmofur 3.8 µM -0.425856857439762 0.326052277756133 no 2283 0.335106076698684 3155 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_305 1682-2595 20.8 µM -0.425962223920569 0.326013419316656 no 2284 0.335067686331843 3219 226033 SGTC_2117 5521686 200 µM -0.426544598835544 0.325798677511217 no 2285 0.334855528625912 3121 803312 SGTC_2856 9022925 19.48 µM -0.4273518445358 0.325501113624102 no 2286 0.334561538219426 3281 4944862 SGTC_1659 st012954 42.1 µM -0.428156236988364 0.325204712079558 no 2287 0.334268687801323 3253 24207262 SGTC_764 1951-2361 146 µM -0.429231114947176 0.324808814960621 no 2288 0.333877520753503 3164 5438930 SGTC_1238 0333-0287 48.8 µM -0.430048894310119 0.324507744394087 no 2289 0.333580037256838 3191 7226 SGTC_2962 9082311 13.18 µM -0.430098727249517 0.324489401791443 no 2290 0.333561912914334 3116 16459453 SGTC_2442 5158906 48.48 µM -0.431715044791916 0.323894695649491 no 2291 0.332974265739659 3281 1893835 SGTC_1863 st057641 20.1 µM -0.432964785624995 0.32343517522208 no 2292 0.332520176388225 3239 3921635 SGTC_3048 9093155 49.47 µM -0.433092819249128 0.323388113398161 no 2293 0.332473669640597 3280 25236002 SGTC_954 1189-0853 2.85 µM -0.435253203155568 0.322594439153355 no 2294 0.33168932428613 3235 2828194 SGTC_1115 galangin 695.678 nM -0.435452392221338 0.322521302388068 no 2295 0.331617044110963 3318 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3088 9117578 49.47 µM -0.436567350549406 0.322112047119234 no 2296 0.331212572548886 3282 678341 SGTC_18 0111-0177 500 nM -0.437437793950918 0.321792693034669 no 2297 0.330896940050849 3212 721752 SGTC_196 k015-0023 18.111 µM -0.438019008944271 0.321579526256423 no 2298 0.330686251894703 3174 5211998 SGTC_1248 0469-0687 58.6 µM -0.438528596860292 0.321392677788437 no 2299 0.330501572395451 3248 4017482 SGTC_3040 9091894 49.47 µM -0.438743774455274 0.32131379308691 no 2300 0.330423602380904 3143 25236966 SGTC_2084 5306078 60.6385 µM -0.440659824582943 0.320611719580821 no 2301 0.329729642862479 3171 679340 SGTC_3194 9111903 49.47 µM -0.441033657487863 0.320474815504637 no 2302 0.329594315404391 3350 17087251 SGTC_3026 9090633 49.47 µM -0.443642150208846 0.319520220995687 no 2303 0.328650663209984 3168 25236842 SGTC_892 0929-0076 29 µM -0.44379906078072 0.31946283660682 no 2304 0.32859393375777 3215 5751038 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.445648065065981 0.318786955843554 no 2305 0.327925742545959 3205 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2065 5221596 34.26 µM -0.446020825346565 0.318650770789001 no 2306 0.327791101432529 3288 788581 SGTC_1076 itraconazole 331 nM -0.44630403998666 0.318547316905782 no 2307 0.32768881919142 3251 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2103 5378138 10 µM -0.447268810301177 0.318195007581068 no 2308 0.327340491932221 3314 244142 SGTC_382 3229-0966 23.2 µM -0.447686874506055 0.318042392316554 no 2309 0.327189597831331 3336 5722370 SGTC_573 3702-0553 84.7 µM -0.447741944692611 0.318022291125089 no 2310 0.327169723165214 3204 1222756 SGTC_1349 flufenamic acid 69 µM -0.449374411396269 0.317426667477361 no 2311 0.32658079358189 3178 3371 A non-steroidal anti-inflammatory. SGTC_1733 st037357 54.9 µM -0.450431783723334 0.317041125396058 no 2312 0.32619956574108 3092 1272339 YGL099W LSG1 SGTC_232 clozapine 119 µM -0.450648647993354 0.316962076255965 no 2313 0.326121399340412 3233 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_252 miconazole 1.30953 nM -0.451712514290335 0.316574407688235 no 2314 0.325738050850001 3255 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2188 6126565 140.678 µM -0.452732857750851 0.316202787864907 no 2315 0.325370558196123 3294 874518 SGTC_340 k038-0059 454 µM -0.454094568771291 0.31570712751416 no 2316 0.324880381123278 3278 23733424 SGTC_155 k072-0202 43.6 µM -0.454824277430109 0.315441651147125 no 2317 0.324617831495453 3275 5857737 SGTC_505 gw-5074 63.9 µM -0.45496119568662 0.315391849325035 no 2318 0.324568577925802 3312 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1807 st050092 58.9 µM -0.455225446356292 0.315295741860628 no 2319 0.324473527774756 3205 5008496 SGTC_2634 4'-methoxyflavone 100 µM -0.457705540613416 0.31439434610537 no 2320 0.323582003437743 3250 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1735 st034310 56.75 µM -0.458728879550886 0.314022733168224 no 2321 0.323214436312841 3350 871153 SGTC_923 1900-2434 73.3 µM -0.460332806592704 0.313440666168118 no 2322 0.32263867833985 3219 5910570 SGTC_1314 1222-0010 41.1 µM -0.462200080934289 0.312763615047844 no 2323 0.321968922611357 3250 3526027 SGTC_941 3237-0776 460 µM -0.462576496104154 0.312627207826189 no 2324 0.321833979578994 3362 760008 SGTC_1327 1436-0082 2.18 µM -0.463183287402909 0.312407369776325 no 2325 0.321616497279527 3222 15992205 SGTC_1230 0170-0365 3.77 µM -0.464611118538701 0.311890335730888 no 2326 0.321104984291898 3395 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_295 k015-0027 31 µM -0.465234072618964 0.311664872920053 no 2327 0.320881920508937 3289 3887424 SGTC_2885 9057732 51.95 µM -0.467952620731507 0.310681788707829 no 2328 0.319909235998996 3361 6471414 SGTC_2196 6573537 42.6665 µM -0.468043340713112 0.310649005696629 no 2329 0.319876798080944 3349 2903087 SGTC_2950 9072895 21.46 µM -0.469233935112352 0.310218906169938 no 2330 0.319451215805639 3328 17332245 SGTC_1600 coumarin 106 71.1 µM -0.470484221707907 0.309767522253258 no 2331 0.319004552214064 3367 100336 A hepatotoxic, DNA x-linker. SGTC_2258 7960471 200 µM -0.47106287132748 0.309558712646987 no 2332 0.318797919118215 3263 2974708 SGTC_3209 9113616 49.47 µM -0.471289804062803 0.309476839217377 no 2333 0.318716897861572 3413 16649353 SGTC_2130 NSC 7 2.4545 µM -0.471814861400456 0.309287443809475 no 2334 0.318529471106811 3320 21448 SGTC_2927 9011802 47.9 µM -0.472004611150668 0.309219010922777 no 2335 0.318461748627629 3324 43912568 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.472047708685495 0.30920346880098 no 2336 0.318446367782417 3314 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_566 0958-0068 16.5 µM -0.472117266578344 0.3091783850878 no 2337 0.318421544303756 3339 6815365 SGTC_2200 6600604 21.907 µM -0.472588171578174 0.309008592446612 no 2338 0.318253511488572 3237 2904777 SGTC_1685 st024049 53.0905 µM -0.473679383694469 0.30861529459505 no 2339 0.317864278528601 3290 1941139 SGTC_583 1488-1091 88.9 µM -0.473926644134169 0.308526206748136 no 2340 0.317776109212746 3341 4303273 SGTC_3320 9137005 35.139 µM -0.474433110405959 0.308343762325952 no 2341 0.317595543294121 3267 4908713 SGTC_1229 0139-0193 12.2 µM -0.47481531069042 0.308206113589559 no 2342 0.317459309543145 3368 3090752 SGTC_89 0302-0250 142.109 µM -0.475235776112485 0.308054714885789 no 2343 0.317309464895782 3336 4203518 YLR208W SEC13 SGTC_2594 a-mangostin 100 µM -0.475683800308913 0.307893428920555 no 2344 0.3171498318534 3356 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3 0833-0587 95.581 µM -0.475790527313785 0.307855013324107 no 2345 0.317111809556059 3283 5382644 SGTC_2866 9034245 58.44 µM -0.477863390021701 0.307109319778454 no 2346 0.316373719949183 3265 6462273 SGTC_1670 st016595 4.04 µM -0.478425110264269 0.306907383149015 no 2347 0.316173832504486 3308 597879 SGTC_492 tmb-8 126 µM -0.480168216124138 0.306281115266781 no 2348 0.315553892626982 3263 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3310 9130229 44.1445 µM -0.480212005552237 0.306265389755351 no 2349 0.315538325481787 3335 7761258 SGTC_1456 k015-0012 13 µM -0.480985884846291 0.305987535747242 no 2350 0.315263265363663 3412 2989616 SGTC_397 arbidol 50 µM -0.481509199333099 0.305799707891905 no 2351 0.315077321567626 3369 131410 A RNA synthesis inhibitor. SGTC_729 4092-0585 94.1 µM -0.483466523247806 0.305097638920865 no 2352 0.314382262003392 3220 2169061 SGTC_2837 9008476 45.46 µM -0.484715226367518 0.30465011810362 no 2353 0.313939182058178 3377 2992805 SGTC_752 1896-0090 130 µM -0.485163134653739 0.304489664100249 no 2354 0.313780315125694 3318 772567 SGTC_2063 5246145 200 µM -0.485682904102699 0.304303514456928 no 2355 0.313596003295924 3359 711240 SGTC_1791 st048313 56.1 µM -0.485988303056498 0.304194162861821 no 2356 0.313487729592295 3322 1204976 SGTC_1936 st074407 74.3 µM -0.487402427690055 0.303688047698604 no 2357 0.312986586737883 3246 809813 SGTC_223 busulfan 5 mM -0.487614121650924 0.30361231479052 no 2358 0.312911595524083 3331 2478 A DNA alkylator. SGTC_1707 st032323 6.317 µM -0.488080492442669 0.303445501733118 no 2359 0.312746414007363 3311 3132057 YMR211W DML1 SGTC_2213 7173844 200 µM -0.489215571543592 0.303039674066151 no 2360 0.312344543226513 3266 892728 SGTC_3036 9090181 49.47 µM -0.491309116437934 0.302291801487 no 2361 0.311603916485568 3319 25236586 SGTC_331 k048-0133 24.5 µM -0.491521450908606 0.302215995970691 no 2362 0.31152884207984 3263 6813582 SGTC_610 4215-0184 155 µM -0.49223861627947 0.301960023898815 no 2363 0.311275334195724 3336 5605015 SGTC_770 0389-1121 67.2 µM -0.493274260385026 0.301590551748088 no 2364 0.310909406480121 3437 6753108 SGTC_2834 9001755 58.44 µM -0.494154050695879 0.301276841211056 no 2365 0.310598693931231 3229 2989575 SGTC_346 4513-0042 7.16 µM -0.494159088113971 0.30127504542086 no 2366 0.310596915272112 3274 2827372 SGTC_684 1140-0066 328 µM -0.495383885665418 0.300838560252892 no 2367 0.31016458368669 3338 6813534 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.496034952203065 0.300606653688258 no 2368 0.309934875583852 3401 688801 SGTC_2565 isoliquiritigenin 100 µM -0.497159080236735 0.300206435140751 no 2369 0.309538437424814 3343 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1127 asiatic acid 681.4 nM -0.497726619598662 0.300004468063644 no 2370 0.309338371513385 3240 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_262 fenpropimorph 62.5 µM -0.499556340876654 0.299353754331224 no 2371 0.308693753040931 3323 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3201 9113999 49.47 µM -0.499620720230633 0.299330870413286 no 2372 0.308671082640949 3384 16649224 SGTC_2655 perillic acid 100 µM -0.500027986970613 0.299186124091173 no 2373 0.308527685552974 3280 5702197 An apoptosis inducer. SGTC_981 1488-1094 54.9 µM -0.500666739671603 0.298959169543907 no 2374 0.308302841945615 3321 3449522 SGTC_2896 9052656 71.43 µM -0.500910071071758 0.298872732293701 no 2375 0.308217207187597 3338 6469436 SGTC_2087 5276107 200 µM -0.504170362303064 0.297715694260849 no 2376 0.307070832718018 3318 144405 SGTC_1135 dihydrocapsaicin 536.708 nM -0.506277043192991 0.296969147235456 no 2377 0.306331088271386 3297 107982 A Capsaicinoid. SGTC_1377 2944-0135 198 µM -0.507561005891847 0.296514568283895 no 2378 0.305880621461617 3344 1894137 SGTC_2669 eugenol 100 µM -0.507933045894403 0.296382909454887 no 2379 0.305750149372993 3343 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_942 3253-1115 227 µM -0.508067909679334 0.296335190001834 no 2380 0.305702859579394 3432 46497897 SGTC_1198 1612-1005 86.7 µM -0.508351519962617 0.296234850408863 no 2381 0.305603422610896 3459 6998509 SGTC_202 3594-0513 34.79 µM -0.510999679161284 0.295298700822981 no 2382 0.304675640716382 3329 708429 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.511237563521682 0.29521467311332 no 2383 0.304592359334495 3334 2333 A French combination drug. SGTC_1359 1582-0056 520 nM -0.512117861273526 0.294903821988006 no 2384 0.304284262353464 3387 3661189 SGTC_2072 5231554 129 µM -0.514093945220249 0.29420657631516 no 2385 0.30359315520578 3437 789545 SGTC_1422 4031-0024 15.5 µM -0.515862244610178 0.293583292239808 no 2386 0.302975312614099 3347 782427 SGTC_272 doxorubicin 8.13 µM -0.517455715018944 0.293022155535982 no 2387 0.302419037655286 3372 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2128 5255449 168.493 µM -0.517833826191155 0.292889077689647 no 2388 0.302287107630479 3315 736008 SGTC_2571 chrysanthemic acid 100 µM -0.518967656523295 0.292490189526012 no 2389 0.301891648036545 3316 2743 An insecticide. SGTC_3262 9137218 49.47 µM -0.519655488965181 0.292248329152633 no 2390 0.301651857815506 3303 17650664 SGTC_978 1416-0512 87.4 µM -0.520312237587849 0.292017485545533 no 2391 0.301422983920277 3391 6814003 SGTC_3058 9093861 49.47 µM -0.521631626048778 0.291553984361435 no 2392 0.300963419486353 3439 17217477 SGTC_1121 fusaric acid 630.51 nM -0.522241333120003 0.2913399102176 no 2393 0.300751155388942 3279 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_430 0958-0115 16.4 µM -0.522373997150739 0.291293340291128 no 2394 0.300704978535475 3293 6833180 SGTC_1911 st060208 74.3 µM -0.523992826041162 0.290725352220075 no 2395 0.30014176479254 3384 688783 SGTC_1059 3448-6867 171 µM -0.524760701126083 0.290456114059052 no 2396 0.299874776976656 3401 3934407 SGTC_527 4476-4215 268 µM -0.525285992147818 0.290271999810256 no 2397 0.299692196848084 3290 4418754 SGTC_2121 5257820 149.641 µM -0.526204079698735 0.28995034189506 no 2398 0.299373209871107 3439 791256 SGTC_3318 9139014 38.6185 µM -0.526599707363527 0.289811782731129 no 2399 0.299235797623541 3379 16643984 SGTC_374 0880-0231 82.3 µM -0.527426431683033 0.28952234255409 no 2400 0.298948746208012 3373 6833587 SGTC_1820 st053765 18.6 µM -0.528024177224768 0.289313153546121 no 2401 0.29874127769047 3398 3690829 SGTC_2840 9008771 71.43 µM -0.528209631456447 0.289248265809618 no 2402 0.29867692261167 3346 2992978 SGTC_1959 st077091 55.8 µM -0.529850603346507 0.28867441190061 no 2403 0.298107758442591 3329 821356 YKL052C ASK1 SGTC_3190 9110366 49.47 µM -0.530544993543016 0.288431742652111 no 2404 0.297867061018033 3369 17123768 SGTC_1776 st049249 45.9 µM -0.531127370119538 0.288228293086385 no 2405 0.297665259383457 3365 1822314 SGTC_1734 st037168 69.4 µM -0.532381566914231 0.287790377393765 no 2406 0.297230874636616 3363 708907 SGTC_2747 doxorubicin 7.63 µM -0.532484121622745 0.28775458326919 no 2407 0.297195368146589 3325 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2995 9067767 71.4286 µM -0.533237740984296 0.287491616049492 no 2408 0.296934509551612 3328 11673567 SGTC_3020 9089140 49.47 µM -0.535921047326364 0.286556229518368 no 2409 0.296006558754494 3440 17217859 SGTC_2400 5203494 178.7 µM -0.536073570857016 0.286503104006892 no 2410 0.295953852517798 3408 6777674 SGTC_2777 climbazole 1.536 µM -0.536426505257361 0.28638019125249 no 2411 0.295831908555183 3406 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2140 5586273 200 µM -0.538249183750193 0.28574582489627 no 2412 0.295202514344577 3412 854421 SGTC_2155 5570423 76 µM -0.53837920086969 0.285700599195206 no 2413 0.295157641334071 3322 797402 SGTC_2316 5844804 197.44 µM -0.538410099902849 0.285689851646535 no 2414 0.295146977564644 3403 776813 SGTC_1889 st059080 5.18 µM -0.538448171526902 0.285676609534488 no 2415 0.295133838658954 3467 176925 Isolated from Daphnopsis sellowiana. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.539799778471916 0.285206681517198 no 2416 0.294667559934819 3400 6312947 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.540213029423473 0.285063075590919 no 2417 0.294525064061102 3359 689007 SGTC_321 4534-3890 65.3 µM -0.540545716586564 0.284947490872494 no 2418 0.294410371045631 3415 699746 SGTC_235 0330-0087 5 mM -0.541739610722731 0.28453288318477 no 2419 0.293998949083193 3405 46494818 YHR062C RPP1 SGTC_1441 4106-0040 13 µM -0.542572762721318 0.284243722443708 no 2420 0.293711998252979 3414 2904180 SGTC_716 1683-5115 658 µM -0.543147718711311 0.284044255343488 no 2421 0.293514049863933 3459 723597 SGTC_2595 hexamethylquercetagetin 100 µM -0.543725985588328 0.283843707177591 no 2422 0.293315023929923 3352 386331 SGTC_1445 4239-0156 97.7 µM -0.544438151279447 0.283596814878126 no 2423 0.293069999137274 3494 4008346 SGTC_2345 9052315 157.45 µM -0.545018471242942 0.283395706723434 no 2424 0.292870406873793 3424 6469265 SGTC_2868 9035608 32.47 µM -0.545866118183809 0.283102080128342 no 2425 0.292578984986106 3413 6462614 SGTC_619 1652-1634 108 µM -0.549003052049677 0.28201671169176 no 2426 0.291501677656923 3366 5400454 SGTC_121 0557-0495 61.343 µM -0.550518039419828 0.28149324983166 no 2427 0.29098205366757 3428 3104427 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.550900671256477 0.281361116197833 no 2428 0.290850883649396 3335 803109 SGTC_1828 st055811 49 µM -0.551392675948093 0.281191257019491 no 2429 0.290682260155281 3434 5877589 SGTC_1274 0865-0114 173 µM -0.55188251439191 0.281022194923792 no 2430 0.290514424531277 3398 870624 SGTC_1663 st014140 55.4 µM -0.552165845521676 0.280924428873771 no 2431 0.290417366175813 3496 4207120 SGTC_901 1112-0062 60.1 µM -0.552493500680712 0.280811388906255 no 2432 0.290305143043664 3405 1908457 SGTC_1204 4049-0315 18.3 µM -0.552902839995178 0.280670199078344 no 2433 0.290164971321197 3503 588402 SGTC_3146 9095609 49.47 µM -0.555161931733042 0.279891608668669 no 2434 0.289391952417924 3395 17173999 SGTC_2115 tiliquinol 12.7705 µM -0.556014096535336 0.279598184490302 no 2435 0.289100609098616 3390 71208 A bioactive hydroxyquinoline. SGTC_1667 st014849 34.6 µM -0.557018969672495 0.279252370537389 no 2436 0.288757234253694 3471 5348460 SGTC_2056 5235370 200 µM -0.55751488730501 0.279081783604637 no 2437 0.288587845211457 3363 5511916 SGTC_1334 1486-0610 236 µM -0.558042314464041 0.278900413569674 no 2438 0.288407744942839 3452 3742339 SGTC_3223 9129970 49.47 µM -0.560153094021225 0.278175139702331 no 2439 0.287687509016103 3446 17248386 SGTC_3069 9117009 49.47 µM -0.56161873586114 0.277672079867532 no 2440 0.287187906186413 3346 41904981 SGTC_998 3996-0085 177 µM -0.561794626475772 0.277611737899642 no 2441 0.287127976824804 3401 715391 SGTC_1261 0712-0010 12.7 µM -0.561932725536974 0.277564365392809 no 2442 0.287080927931998 3505 2840123 SGTC_1178 0988-0033 191 µM -0.562413203689971 0.277399576415314 no 2443 0.286917262548445 3472 5392207 SGTC_1434 4073-0095 163 µM -0.56334141827769 0.277081363364813 no 2444 0.286601209854878 3477 24133745 SGTC_2216 7189485 200 µM -0.570050045261639 0.274786819606111 no 2445 0.28432187772341 3473 731273 SGTC_1578 josamycin 24.2 µM -0.571066560838669 0.274439960950693 no 2446 0.283977262325578 3394 5282165 A P450 substrate. SGTC_1969 st069479 40.1 µM -0.571806590473591 0.274187581690393 no 2447 0.283726505962171 3487 3895485 SGTC_2174 5790901 200 µM -0.571889811720868 0.274159207138619 no 2448 0.283698313377873 3459 786020 SGTC_2979 9012552 45.46 µM -0.572278062632036 0.274026850913462 no 2449 0.283566804645424 3537 17100905 SGTC_1557 sumaresinolic acid 42.3 µM -0.57278880428234 0.273852785230301 no 2450 0.283393850227612 3424 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2635 hydroquinidine 100 µM -0.573023082414431 0.273772959276123 no 2451 0.283314532642087 3454 442912 An experimental heart treatment. SGTC_466 geldanamycin 89.2 µM -0.573482346207351 0.273616507005135 no 2452 0.283159074442757 3391 5288382 HSP90 inhibitor. SGTC_13 0199-0087 65 µM -0.573711430624634 0.273538483913762 no 2453 0.28308154596373 3492 4589825 SGTC_2322 7413319 38.22 µM -0.574146877364443 0.273390206937745 no 2454 0.282934206880844 3488 1840400 SGTC_2956 9076196 2.52 µM -0.576630533874265 0.272545241559084 no 2455 0.282094534018821 3531 16423868 SGTC_636 0kpi-0074 126 µM -0.577910430218453 0.272110314520433 no 2456 0.281662296525996 3454 616434 SGTC_3292 9120825 59.784 µM -0.578533058064282 0.271898861521476 no 2457 0.281452142599523 3541 24824900 SGTC_2838 9002687 71.43 µM -0.578638246501233 0.271863146151567 no 2458 0.281416646097135 3417 6457060 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.57865371665642 0.271857893657848 no 2459 0.281411425777792 3440 115019 SGTC_798 1287-0182 476 µM -0.579620952932953 0.271529593730216 no 2460 0.281085130014325 3533 1649755 SGTC_956 1185-0240 191 µM -0.580350203051057 0.271282201835817 no 2461 0.280839239447304 3448 1416193 SGTC_1371 2421-0008 32.7 µM -0.580474038117226 0.27124020300522 no 2462 0.280797494729643 3424 2827552 SGTC_877 0771-0151 33.1 µM -0.581417204829872 0.270920433128164 no 2463 0.280479652352241 3439 6166523 SGTC_1674 st016616 23.6 µM -0.582503342415917 0.270552423807174 no 2464 0.280113845401458 3434 625830 SGTC_2339 9000433 200 µM -0.58474702317752 0.2697930028679 no 2465 0.279358915314495 3412 2988954 SGTC_1771 st048882 4.1505 µM -0.584877543029033 0.269748858553281 no 2466 0.279315029808888 3368 4580403 SGTC_1827 berberine 7.24 µM -0.586644195222321 0.269151699005428 no 2467 0.278721347049356 3379 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_818 4072-2707 53.5 µM -0.586802897278998 0.269098087401007 no 2468 0.278668045372403 3449 882871 SGTC_2713 st079149 53.4 µM -0.587092921177532 0.269000127428778 no 2469 0.278570650762555 3478 3103253 SGTC_1935 st074532 41.6 µM -0.588596422320423 0.268492584200039 no 2470 0.27806601722952 3544 2829742 SGTC_1583 clindamycin 39.6 µM -0.589216344734603 0.268283454637644 no 2471 0.277858077053333 3429 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_301 4119-0100 24.5 µM -0.590861044301354 0.26772901598007 no 2472 0.277306764676763 3480 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1952 st077036 64.1 µM -0.592426011892496 0.267201992092111 no 2473 0.276782676072294 3528 2937007 SGTC_678 1218-2179 85.9 µM -0.592943301618264 0.267027903034616 no 2474 0.276609548796206 3493 6820081 YOR116C RPO31 SGTC_1656 st012921 11 µM -0.593235190569346 0.266929695800967 no 2475 0.276511882408607 3453 6732821 SGTC_2071 5230951 39.92 µM -0.593402806562192 0.266873308961198 no 2476 0.276455805542691 3557 1799272 SGTC_2828 7998861 71.43 µM -0.593890273 0.266709357074359 no 2477 0.276292752625114 3457 2988188 SGTC_1258 0671-0043 57.1 µM -0.595565347354812 0.266146359752873 no 2478 0.275732815981266 3470 4298767 SGTC_2581 avocatin a 64 µM -0.596179351004471 0.265940142171395 no 2479 0.275527709267099 3453 6710728 A skin care supplement. SGTC_858 0438-0351 2.77 µM -0.596340507536132 0.265886029996332 no 2480 0.275473887678946 3487 2799119 SGTC_214 4373-3496 70 µM -0.597111603725546 0.265627193174625 no 2481 0.275216435604743 3577 3779166 SGTC_2725 haloperidol 53.21 µM -0.597687688124881 0.265433900140108 no 2482 0.275024171020561 3483 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1397 3532-0190 20.1 µM -0.597846975270921 0.265380467278323 no 2483 0.274971021605564 3440 5322280 SGTC_2378 9074213 121.43 µM -0.598260239548383 0.265241863264504 no 2484 0.274833151126232 3519 657714 SGTC_994 3910-0338 138 µM -0.598532128205375 0.265150695032193 no 2485 0.274742464027893 3562 3479481 SGTC_2715 st079500 56.4 µM -0.598770368945234 0.265070822521303 no 2486 0.274663012153801 3483 28246688 SGTC_2625 euphol 100 µM -0.598897670035916 0.265028148610936 no 2487 0.274620562640467 3538 6708538 A triterpene alcohol. SGTC_356 1634-0012 32.5 µM -0.599144723348119 0.2649453412853 no 2488 0.274538190076464 3527 735457 SGTC_2710 st078562 53.7235 µM -0.59918076945824 0.264933260449836 no 2489 0.274526172594452 3479 17250908 SGTC_2861 9024595 19.48 µM -0.599407328046685 0.264857335863922 no 2490 0.274450645733507 3445 16482810 SGTC_1482 3346-2049 8.48 µM -0.599465181042327 0.264837949871488 no 2491 0.274431361173226 3505 3826804 SGTC_3273 9137859 49.47 µM -0.599543345342726 0.264811758898324 no 2492 0.274405307160062 3563 2377234 SGTC_2614 arthonioic acid 13.39 µM -0.600149290096801 0.264608766095991 no 2493 0.274203372844996 3487 6710684 SGTC_87 0100-0052 35.5 µM -0.600195957189591 0.264593135802473 no 2494 0.274187823832325 3586 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2235 salicylic acid 500 µM -0.600249073718022 0.264575345959396 no 2495 0.274170126461592 3510 338 A COX inhibitor and kinase inhibitor. SGTC_516 3992-2719 87.3 µM -0.601109563095012 0.264287234761784 no 2496 0.273883507149743 3404 5350887 YDR037W KRS1 SGTC_2580 diallyl disulphide 81.36 µM -0.60126578803078 0.264234944279069 no 2497 0.273831486277872 3477 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_917 harmaline 728.087 nM -0.601774898427819 0.264064575091836 no 2498 0.273661993048496 3480 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2942 9052777 62.25 µM -0.603108606008264 0.263618527436911 no 2499 0.27321822084102 3578 6469503 SGTC_2858 9025781 8.96 µM -0.603578386786383 0.263461504673595 no 2500 0.273061992926746 3566 4894980 YPL153C RAD53 SGTC_2887 9044784 58.44 µM -0.604362371273987 0.263199566654535 no 2501 0.272801373664984 3529 6465546 SGTC_2947 9072639 7.68 µM -0.604558459118643 0.263134072308432 no 2502 0.272736207654927 3536 16488146 SGTC_821 1114-0266 29.2 µM -0.604864543234831 0.263031855289591 no 2503 0.272634501947859 3516 3123235 SGTC_1853 st056710 91.2 µM -0.605208138202151 0.262917135675782 no 2504 0.2725203545565 3589 269167 SGTC_1948 st076329 66.6 µM -0.605411464224608 0.262849261158535 no 2505 0.272452817785798 3449 24208413 SGTC_1227 3909-8010 46.6 µM -0.605934156498114 0.262674816581116 no 2506 0.272279238480379 3484 15982272 SGTC_2560 caryophyllene 100 µM -0.60676253404009 0.262398473242407 no 2507 0.272004257671361 3538 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.607091017210705 0.26228893384248 no 2508 0.271895255585969 3576 368090 SGTC_1446 4239-0190 62 µM -0.6074463767666 0.262170458345942 no 2509 0.271777359461141 3479 1340085 SGTC_3089 9117425 49.47 µM -0.607718741616634 0.262079671528342 no 2510 0.271687015361473 3480 9401657 SGTC_478 N-arachidonylglycine 10 µM -0.608193259445444 0.261921539972266 no 2511 0.271529652335609 3482 5283389 SGTC_1239 0337-0584 35.4 µM -0.608218294195239 0.261913198580476 no 2512 0.271521351392094 3586 914301 YML130C ERO1 SGTC_575 k072-0246 11.9 µM -0.608597871275041 0.261786743022863 no 2513 0.271395507907317 3541 6796779 SGTC_2295 7971645 200 µM -0.609404112956323 0.261518248719584 no 2514 0.27112830618276 3489 2978226 YKL099C UTP11 SGTC_588 3970-1144 52.9 µM -0.609883867731276 0.261358548081548 no 2515 0.27096936985763 3491 1888707 SGTC_2741 miltefosine 3.04 µM -0.6131709416068 0.260265696761767 no 2516 0.269881658223534 3449 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1845 st056753 3.01 µM -0.613200631224452 0.260255836614748 no 2517 0.269871843727566 3474 5375839 SGTC_422 cantharidin 155 µM -0.615020561865488 0.259651791609325 no 2518 0.269270570689002 3520 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_133 0724-0033 378.92 µM -0.615372014294497 0.259535226041231 no 2519 0.269154534444819 3443 280309 SGTC_2684 capsaicin 100 µM -0.61783682837997 0.258718485743495 no 2520 0.268341452038163 3554 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3149 9097855 49.47 µM -0.618980914671003 0.258339834125738 no 2521 0.267964465957577 3535 25236625 YMR079W SEC14 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.619203605882504 0.258266164706711 no 2522 0.26789111834452 3602 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.619240643562824 0.258253913171603 no 2523 0.267878920256395 3473 279621 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.622579881954167 0.257150579997379 no 2524 0.266780317491626 3564 66535 A nucleotide analog. SGTC_289 k017-0060 526 µM -0.622912813499267 0.257040709072828 no 2525 0.266670908633614 3519 5512909 SGTC_1956 st077085 54 µM -0.623064158578521 0.256990771672904 no 2526 0.266621180707849 3530 24208685 SGTC_3192 9110362 49.47 µM -0.624194185878555 0.256618070606318 no 2527 0.266250032363461 3618 16649480 SGTC_736 0958-0254 92.6 µM -0.624255683215227 0.256597795880864 no 2528 0.266229841565584 3601 6812352 SGTC_694 1315-0438 43.2 µM -0.62481661719729 0.256412903095596 no 2529 0.266045711575338 3493 6793154 SGTC_744 1594-0068 283 µM -0.624960027222946 0.25636564400979 no 2530 0.265998646717789 3566 668392 SGTC_831 k061-1017 217 µM -0.625161123435926 0.256299382766338 no 2531 0.265932657288334 3584 1240153 SGTC_2558 carylophyllene oxide 100 µM -0.625496385351742 0.256188933747125 no 2532 0.265822660023206 3631 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2611 pyromycin 23.93 µM -0.627385178111117 0.25556715204986 no 2533 0.265203390557448 3521 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2176 5809774 33.9695 µM -0.627484737226823 0.255534399540962 no 2534 0.265170768921457 3539 2870539 SGTC_353 1988-1175 58.3 µM -0.627857167971683 0.255411898400203 no 2535 0.26504875597573 3433 2788357 SGTC_833 3852-0053 558 µM -0.630185797101596 0.254646654458671 no 2536 0.264286515314159 3610 3123681 SGTC_1484 3473-2379 286 µM -0.633348784304776 0.253609146678351 no 2537 0.263252951173252 3673 671917 SGTC_524 r073-0010 27.8 µM -0.634135644982834 0.253351389764572 no 2538 0.262996151048492 3524 2772106 SGTC_2789 5281112 71.43 µM -0.634949158582486 0.253085046839544 no 2539 0.262730787155677 3560 765948 SGTC_2507 purpurin 79.67 µM -0.635441910321216 0.252923792443059 no 2540 0.262570120741814 3507 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_88 0180-0332 8.668 µM -0.636681254237298 0.252518452808933 no 2541 0.262166243215583 3616 3101745 SGTC_1156 4092-0367 4.88 µM -0.637250223043516 0.252332480658482 no 2542 0.261980934272808 3544 1357585 SGTC_2537 larixol 68.93 µM -0.637750769402611 0.252168932670068 no 2543 0.261817965559533 3591 6708759 SGTC_1241 0364-0022 50.8 µM -0.638155584058181 0.25203670485994 no 2544 0.261686203376144 3549 4563895 SGTC_2928 9011484 9.79 µM -0.638286576567242 0.251993925576796 no 2545 0.261643574215916 3562 2994751 SGTC_1939 st074455 53.6 µM -0.6384293882597 0.251947290773378 no 2546 0.261597102775655 3601 1644229 SGTC_3280 9140961 49.47 µM -0.639080456648277 0.251734743735383 no 2547 0.261385296466895 3545 4901226 SGTC_2288 7946289 167.31 µM -0.642929879460411 0.250480002989145 no 2548 0.26013480017196 3622 1246052 SGTC_935 2996-0153 430 µM -0.64465087624693 0.249920108483674 no 2549 0.259576728555967 3592 23738523 SGTC_1812 st052057 4.327 µM -0.646352582711451 0.249367143531052 no 2550 0.259025520693284 3596 3645418 SGTC_1150 3909-7983 10.9 µM -0.6464104183488 0.249348361429923 no 2551 0.259006797517684 3570 23965914 SGTC_2468 5987765 72.9 µM -0.646590305887212 0.249289947827979 no 2552 0.258948566860259 3593 26772094 SGTC_943 3253-1379 105 µM -0.647901489804476 0.248864396272274 no 2553 0.258524333551363 3596 668464 SGTC_554 4483-2211 187 µM -0.648758472692652 0.248586467126883 no 2554 0.258247251543943 3551 747107 SGTC_268 camptothecin 39.6153 µM -0.649819909867981 0.248242460527863 no 2555 0.25790427834488 3614 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.654126200075808 0.246849420897932 no 2556 0.256515251509964 3593 6708561 SGTC_333 3486-0131 40.1 µM -0.656518009849753 0.246077506856324 no 2557 0.255745441775562 3674 6744690 SGTC_699 0375-0592 111 µM -0.656866309213997 0.245965207537946 no 2558 0.255633441478931 3637 762578 SGTC_204 PMA1.184 62.41 µM -0.657261152011116 0.2458379348646 no 2559 0.255506505507956 3635 2252213 YGL008C PMA1 SGTC_3297 9117502 71.43 µM -0.659605442742393 0.245083010389784 no 2560 0.254753530295664 3606 7453720 SGTC_3126 9127922 49.47 µM -0.66021391739721 0.244887269256973 no 2561 0.254558281167239 3640 45595682 SGTC_1683 st010134 710 nM -0.660297280881226 0.244860458485912 no 2562 0.25453153735548 3629 3818134 SGTC_1417 3966-0327 90.4 µM -0.660466032358721 0.244806190671481 no 2563 0.254477404755859 3649 651118 SGTC_92 0063-0024 660.874 µM -0.660645698745435 0.244748419910714 no 2564 0.254419777470232 3662 3594437 SGTC_1197 1601-0112 267 µM -0.662098833172071 0.244281442203721 no 2565 0.25395394178921 3608 7350313 SGTC_982 1491-0518 27.5 µM -0.663194565084805 0.243929636851176 no 2566 0.253602975931511 3577 3091256 SGTC_1633 st005664 67.9 µM -0.663747542309857 0.243752196952724 no 2567 0.253425952632555 3615 2063822 SGTC_2515 chrysin 20.77 µM -0.663996720610048 0.243672263142777 no 2568 0.253346204999064 3607 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2860 9025725 38.96 µM -0.664217915697663 0.243601317916668 no 2569 0.25327542423554 3567 40546248 SGTC_2561 acetosyringone 100 µM -0.665095587646163 0.2433199269069 no 2570 0.252994678321731 3612 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_279 1273-0055 2.93 µM -0.666226009608401 0.242957760531032 no 2571 0.252633325239434 3660 2847562 SGTC_1759 st043059 70 µM -0.667017819341949 0.242704253053603 no 2572 0.252380375656637 3607 669426 SGTC_3250 9135583 49.47 µM -0.667196696302416 0.242647003262826 no 2573 0.252323250555644 3631 7699353 SGTC_1949 st076024 69.1 µM -0.66761878240359 0.242511943074555 no 2574 0.252188482628382 3603 2921930 SGTC_77 0828-0286 12.516 µM -0.669294134560512 0.241976261395796 no 2575 0.251653933816525 3605 745345 SGTC_2434 5670830 169.91 µM -0.671117246918946 0.241394064444523 no 2576 0.251072920333509 3618 1549830 SGTC_2991 9074669 71.4286 µM -0.671403771592717 0.241302634233413 no 2577 0.250981671447608 3638 17333109 SGTC_2499 avocadenofuran 51.48 µM -0.671612742191998 0.241235963446892 no 2578 0.250915132106721 3589 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_899 1083-0020 478 µM -0.671876777854075 0.241151738808328 no 2579 0.250831072585696 3666 767123 SGTC_3287 9117173 37.0625 µM -0.672355688792225 0.240999011985584 no 2580 0.250678642506589 3602 2789709 SGTC_251 melphalan 456.522 µM -0.673040087262969 0.240780845607326 no 2581 0.250460894047455 3684 460612 A DNA alkylator. SGTC_2064 5220758 200 µM -0.673325769930479 0.240689810062644 no 2582 0.250370030811184 3681 788518 SGTC_1029 k015-0030 64.7 µM -0.674488499674553 0.240319488343412 no 2583 0.250000397386613 3651 2208316 SGTC_1769 st044406 64.4 µM -0.675230809467354 0.24008323003995 no 2584 0.249764567589973 3637 670903 SGTC_2513 baicalein 25.65 µM -0.675851197947606 0.239885873359924 no 2585 0.24956756251354 3603 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3014 9081533 49.47 µM -0.676544288427812 0.239665493565475 no 2586 0.249347568504197 3648 21367265 SGTC_1093 fluphenazine 7.97 µM -0.677624516791319 0.239322237182601 no 2587 0.249004898621778 3692 6602611 An atypical antipsychotic. SGTC_2982 9019404 25.97 µM -0.678205259202745 0.239137809908635 no 2588 0.248820779220668 3529 22333232 SGTC_1927 st060202 13.8 µM -0.681280684829765 0.238162438250191 no 2589 0.24784695132772 3614 688887 SGTC_2734 clemastine 41.6 µM -0.68148386369783 0.238098076897045 no 2590 0.247782686834189 3633 26987 Clemastine is a selective histamine H1 antagonist. SGTC_685 1278-0033 54.9 µM -0.682322619360884 0.237832483607095 no 2591 0.247517486670444 3696 3590572 SGTC_1427 4048-4900 550 nM -0.682353277766755 0.237822778653952 no 2592 0.247507795881829 3641 24132586 SGTC_1402 3909-7673 35.9 µM -0.682586909033296 0.23774882954584 no 2593 0.247433954238894 3638 5328014 SGTC_932 2857-0803 154 µM -0.683403941152861 0.237490321259656 no 2594 0.247175815165274 3716 674898 SGTC_2946 9065502 71.43 µM -0.683795937487714 0.237366348735177 no 2595 0.247052016136544 3485 16489101 SGTC_2038 4100038 30.985 µM -0.684199400019559 0.237238787035576 no 2596 0.246924630539556 3647 3596803 SGTC_2396 5342950 42.78 µM -0.684895855151992 0.237018679253319 no 2597 0.246704820855087 3651 1886677 SGTC_3128 9127691 49.47 µM -0.685393653785332 0.236861423705132 no 2598 0.246547773805625 3616 41316314 SGTC_1293 1000-1278 195 µM -0.685555601169217 0.236810276583908 no 2599 0.246496693693543 3692 678847 SGTC_2447 5741742 33.78 µM -0.68689013630695 0.236389027610362 no 2600 0.246075981567572 3690 1776504 SGTC_1468 k284-1086 134 µM -0.687368149476651 0.236238242094113 no 2601 0.245925381687949 3673 15996457 SGTC_2525 harmine 47.85 µM -0.688606934189119 0.235847723761726 no 2602 0.245535328108969 3631 5280953 A monoamine oxidase inhibitor SGTC_2172 5754775 163.918 µM -0.690716915350913 0.235183386833579 no 2603 0.244871728557337 3601 2263357 SGTC_2816 7982706 58.44 µM -0.690728899849945 0.23517961641469 no 2604 0.244867962131618 3662 2981853 SGTC_2290 7904846 200 µM -0.691703864477214 0.234872996617598 no 2605 0.244561659810038 3706 2962154 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.692708365487495 0.234557319044288 no 2606 0.244246294089768 3636 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2351 9026858 72.31 µM -0.694732805682961 0.233921825935989 no 2607 0.243611382508298 3611 1409300 SGTC_2891 9063876 19.48 µM -0.69524301772983 0.233761815632912 no 2608 0.243451508864023 3644 6472478 SGTC_2189 6047310 154.431 µM -0.695705829749303 0.233616723193079 no 2609 0.243306536940711 3618 711535 SGTC_3112 9123419 49.47 µM -0.69588063410191 0.233561934693995 no 2610 0.243251793107948 3710 17015854 SGTC_741 4582-0002 126 µM -0.696786288941381 0.233278191644342 no 2611 0.242968273987277 3644 2912688 SGTC_1768 st044301 37.178 µM -0.696797714886738 0.233274613100528 no 2612 0.242964698188456 3687 3931349 SGTC_1835 st008666 49.2 µM -0.696827753729255 0.233265205244096 no 2613 0.242955297539091 3615 690455 SGTC_1629 st005085 44.9 µM -0.697527862237536 0.233045998116889 no 2614 0.24273625447653 3668 24207091 SGTC_870 0573-2213 57.6 µM -0.697561356763643 0.233035513697892 no 2615 0.242725777718829 3672 3916321 SGTC_1960 st011366 51.8 µM -0.699949024343224 0.232288803876461 no 2616 0.241979569856393 3689 3972846 SGTC_2729 fluphenazine 10.66 µM -0.700431843844138 0.23213797077124 no 2617 0.241828827667462 3623 3372 An atypical antipsychotic. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.702192634120881 0.231588360993228 no 2618 0.241279519295706 3744 6728940 SGTC_2850 9015429 58.44 µM -0.70226027725435 0.231567261468977 no 2619 0.241258430406628 3696 6457570 SGTC_2385 9074692 200 µM -0.702710088023488 0.231426981902012 no 2620 0.241118219785612 3685 17046906 SGTC_2903 5923464 63.88 µM -0.702749774190047 0.231414607509867 no 2621 0.241105851328303 3713 2876576 SGTC_1118 chelidonine 707.474 nM -0.70547764738718 0.230564924590001 no 2622 0.240256518793794 3684 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_668 1682-0499 62.6 µM -0.705881657020318 0.230439231327668 no 2623 0.240130867784104 3719 682214 SGTC_2106 5357045 167.29 µM -0.706329554956506 0.230299928561145 no 2624 0.239991608954561 3712 668842 SGTC_1720 st037298 9.481 µM -0.708158654542548 0.229731541110606 no 2625 0.239423369229677 3694 597396 SGTC_3219 9131112 49.47 µM -0.709494613088515 0.229316892759933 no 2626 0.239008796610393 3642 17612988 YMR079W SEC14 SGTC_1632 st005650 90 µM -0.71026469131856 0.229078070362194 no 2627 0.238770005536603 3707 2759605 SGTC_743 1275-0778 158 µM -0.710748533566867 0.228928088998016 no 2628 0.238620039243058 3699 2849257 YMR203W TOM40 SGTC_1307 1187-1599 12.2 µM -0.712315095791971 0.228442864449765 no 2629 0.238134839092855 3701 1538471 SGTC_3076 9116187 49.47 µM -0.713946713743479 0.227938104560132 no 2630 0.237630065005005 3673 27241210 SGTC_589 1227-0070 34.1 µM -0.715177274544633 0.227557831760508 no 2631 0.237249754782555 3698 2841384 SGTC_553 k007-0256 45.7 µM -0.715718134462399 0.227390806156944 no 2632 0.237082705468063 3739 6287000 SGTC_2809 7964133 12.99 µM -0.717970018742503 0.22669613360659 no 2633 0.236387886557307 3735 1253665 SGTC_1767 st044992 70.3 µM -0.72104980091317 0.2257480088889 no 2634 0.235439437413286 3715 9600693 SGTC_490 phenamil 164 µM -0.724272040621181 0.224758433565494 no 2635 0.234449369227639 3672 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2787 5284540 71.43 µM -0.726553158492965 0.22405937385982 no 2636 0.23374986590738 3749 736958 SGTC_504 lovastatin 124 µM -0.728737793665824 0.223391041125349 no 2637 0.233081034829749 3706 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_902 1120-0002 2.07 µM -0.729076268882755 0.223287594951259 no 2638 0.232977505017764 3720 3280475 SGTC_822 1487-0950 154 µM -0.731212977290296 0.222635195053181 no 2639 0.23232453736661 3716 1958375 SGTC_2118 5526350 200 µM -0.731439453358948 0.222566108999333 no 2640 0.232255387112604 3758 743594 SGTC_1893 st059353 36.1 µM -0.731594886316081 0.222518701572818 no 2641 0.23220793517892 3743 3112488 SGTC_3090 9117696 49.47 µM -0.733174500824035 0.222037242060819 no 2642 0.231726002775258 3686 7923821 SGTC_2654 protoveratrine a 100 µM -0.733201634319778 0.222028977090249 no 2643 0.231717729354439 3713 5702278 A heart drug and vasodilator. SGTC_1242 0402-0103 60.1 µM -0.733220231833719 0.222023312315088 no 2644 0.231712058781028 3691 432868 SGTC_2031 5180455 200 µM -0.733335319712523 0.221988258553233 no 2645 0.231676969022138 3718 29949 SGTC_1184 1269-1718 139 µM -0.734017526528798 0.221780535141248 no 2646 0.231469028149638 3760 5403821 SGTC_3354 9151612 71.43 µM -0.734385814594003 0.221668442216139 no 2647 0.231356814926941 3743 27261949 SGTC_1025 k007-0731 70 µM -0.734799175246346 0.221542669471094 no 2648 0.231230904738978 3710 6256118 SGTC_2403 6032726 181.2 µM -0.734814023241626 0.221538152448586 no 2649 0.231226382731824 3755 2881040 SGTC_1816 st051957 91.6 µM -0.736318526576564 0.221080728938527 no 2650 0.230768437010898 3724 674121 SGTC_2557 derrustone 83.84 µM -0.736784860070472 0.220939056462963 no 2651 0.230626595786424 3717 629853 An antioxidant. SGTC_3213 9129884 49.47 µM -0.737358819330869 0.220764758561412 no 2652 0.230452085719346 3708 17190742 SGTC_3138 9097216 49.47 µM -0.737987471835407 0.220573941999548 no 2653 0.230261031115451 3737 25237486 SGTC_782 0083-0095 30.5 µM -0.738270430140007 0.220488085763031 no 2654 0.230175065805316 3729 3591729 An indicator and reagent. SGTC_672 1441-0018 53.7 µM -0.739436027463173 0.220134617985341 no 2655 0.229821136088773 3731 251141 SGTC_2971 9092186 9.93 µM -0.740433476731825 0.219832399390566 no 2656 0.229518506064226 3759 25236400 SGTC_1345 1488-0192 31.4 µM -0.740973218015945 0.219668961750027 no 2657 0.229354839590841 3749 658348 SGTC_148 3253-0744 288.01 µM -0.742999086001345 0.219056136765914 no 2658 0.228741116896947 3703 6893655 SGTC_3207 9114163 49.47 µM -0.745526910478406 0.218292850450208 no 2659 0.227976624588772 3761 849233 SGTC_2201 6605497 169.863 µM -0.746177861848677 0.218096541566875 no 2660 0.22777998972857 3728 670741 SGTC_1621 st003705 32.4 µM -0.747408246173997 0.217725769841553 no 2661 0.227408584634268 3760 24207032 SGTC_2661 dactinomycin 12.96 µM -0.748293014197832 0.217459373217566 no 2662 0.227141718634052 3745 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2171 5739187 198.077 µM -0.748609987545543 0.217363980860728 no 2663 0.227046155288281 3686 2262761 SGTC_1020 4335-0961 93.3 µM -0.749694009105298 0.217037929887773 no 2664 0.226719508261892 3710 669075 SGTC_1721 st082152 9.2685 µM -0.750545327289988 0.216782069467166 no 2665 0.226463167502939 3704 5296051 SGTC_972 1319-0219 195 µM -0.751575289946504 0.216472751406561 no 2666 0.226153253924714 3723 23903702 SGTC_2940 9060638 45.86 µM -0.752313529738747 0.216251200684748 no 2667 0.225931266673614 3768 4027022 SGTC_2149 5554786 194.827 µM -0.752707604940525 0.216132989831763 no 2668 0.225812819490921 3785 745063 YPR165W RHO1 SGTC_3327 9140648 26.9345 µM -0.753289326932522 0.215958558928894 no 2669 0.22563803551773 3756 8029710 SGTC_2993 9054257 71.4286 µM -0.753406962808665 0.215923295412195 no 2670 0.225602699993464 3739 6470217 YGL055W OLE1 SGTC_123 0083-0120 66.675 µM -0.754678062701641 0.215542472702177 no 2671 0.225221086139317 3750 16001701 SGTC_3099 9120367 49.47 µM -0.755032597107863 0.215436323380705 no 2672 0.225114711885003 3775 24824940 SGTC_3169 9102970 49.47 µM -0.755130022488241 0.215407159061622 no 2673 0.225085485428901 3825 17027839 SGTC_1269 0831-0796 3.05 µM -0.755892972257113 0.215178849015425 no 2674 0.224856683923175 3756 927758 SGTC_114 0364-0001 490.298 µM -0.75660211713717 0.21496676590171 no 2675 0.224644136287043 3818 4003655 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.75766105786564 0.214650295850798 no 2676 0.224326958740393 3732 6708514 SGTC_2748 diazoxide 86.69 µM -0.758612510116289 0.214366180383489 no 2677 0.22404219346057 3758 3019 A potassium channel activatior. SGTC_1383 3049-0032 20.7 µM -0.758881172194299 0.214285994163408 no 2678 0.223961821332092 3804 712864 SGTC_3049 9092223 49.47 µM -0.760308595734467 0.21386025094824 no 2679 0.223535072504211 3750 8623917 SGTC_2475 5812728 15.03 µM -0.76032764959945 0.213854571277375 no 2680 0.223529379206686 3764 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_203 k066-0004 30.888 µM -0.760592265953392 0.213775702198703 no 2681 0.223450320330116 3830 6795412 SGTC_2827 7993847 71.43 µM -0.760937764076841 0.213672751757794 no 2682 0.223347120524193 3800 2985692 SGTC_908 3448-7491 47.7 µM -0.761914949048184 0.213381729673686 no 2683 0.223055383626206 3805 1203031 SGTC_1170 0310-0127 64.8 µM -0.762624050955466 0.213170691973872 no 2684 0.222843818407691 3789 774975 SGTC_2082 5219693 150 µM -0.76298785646505 0.213062466116784 no 2685 0.222735319032593 3766 2834649 SGTC_594 1487-1584 10.8 µM -0.763296308625877 0.212970732040137 no 2686 0.222643351527685 3760 5013332 SGTC_3238 9133470 49.47 µM -0.76346049314428 0.212921912749278 no 2687 0.222594407415358 3772 3534688 SGTC_124 0136-0217 7.121 µM -0.763536349257674 0.212899359590612 no 2688 0.222571796453014 3847 3976905 SGTC_306 1672-3436 11.6 µM -0.764779833322851 0.212529851946785 no 2689 0.222201329185362 3784 6797378 SGTC_2187 6125751 200 µM -0.766250431930225 0.212093339906319 no 2690 0.221763652912901 3794 874498 SGTC_781 4335-2806 94.4 µM -0.766267035992228 0.212088414382211 no 2691 0.221758714062423 3913 845254 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.767408540766145 0.211749952255549 no 2692 0.221419326062413 3748 2724278 An inhibitor of dopamine biosynthesis. SGTC_3186 9110464 49.47 µM -0.768650606608611 0.211382032570955 no 2693 0.221050377217873 3757 17018021 SGTC_2506 ethyl hematommate 54.16 µM -0.768940616398619 0.211296181001312 no 2694 0.220964282091955 3873 3940691 An allergen. SGTC_441 propafenone 146 µM -0.770487373718342 0.210838639704158 no 2695 0.220505420980063 3755 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2428 5615643 7.78 µM -0.771530569612747 0.210530383641945 no 2696 0.220196254999441 3820 2253075 SGTC_3346 9158254 43.5805 µM -0.77264858069779 0.210200314098269 no 2697 0.219865192605661 3809 17639500 SGTC_1579 chlormadinone acetate 49.4 µM -0.772803060397508 0.210154731087755 no 2698 0.219819470972289 3807 45114258 A steroidal progestin. SGTC_1315 1237-0019 3.69 µM -0.775012377310024 0.209503453717487 no 2699 0.219166172917746 3781 825140 SGTC_2472 5377652 49.4 µM -0.776620555010635 0.209030131819271 no 2700 0.218691335349827 3860 1610903 SGTC_2439 5492030 7.2 µM -0.776842638607175 0.208964817282285 no 2701 0.218625808541181 3804 5722370 SGTC_3091 9116372 49.47 µM -0.778951992597507 0.208345058192655 no 2702 0.218003997477378 3861 17169793 SGTC_3279 9140807 49.47 µM -0.779239216851292 0.208260751453446 no 2703 0.21791940631754 3829 45595718 SGTC_2034 5197015 53.07 µM -0.780117201320093 0.208003168213712 no 2704 0.217660946224384 3783 780676 SGTC_418 lividomycin a 100 µM -0.781357243415528 0.207639685025713 no 2705 0.21729620550528 3791 72394 An antibiotic. SGTC_2922 7999257 32.47 µM -0.781498343068774 0.207598349456636 no 2706 0.217254725431179 3772 2988377 SGTC_2264 7948757 110.76 µM -0.78299107422055 0.207161347265949 no 2707 0.216816176783182 3789 2971411 SGTC_1459 k035-0031 35.7 µM -0.784558527590935 0.206703056057787 no 2708 0.216356226923731 3669 3877128 YMR208W ERG12 SGTC_2967 9089538 49.85 µM -0.784938924700403 0.206591926337343 no 2709 0.216244689305765 3854 728216 SGTC_2395 5646831 180.19 µM -0.785466031739982 0.206437995085522 no 2710 0.216090189376961 3803 6808628 SGTC_2781 5567276 71.43 µM -0.78815425285142 0.205654010589369 no 2711 0.215303242135162 3855 2853274 SGTC_2696 st077691 74.316 µM -0.788774073704156 0.205473498975449 no 2712 0.215122032587876 3821 757133 SGTC_1879 gemcitabine 100 µM -0.788980817787982 0.205413309431196 no 2713 0.215061609011127 3797 60750 A nucleoside analog which inhibits DNA replication. SGTC_1352 1496-0991 99 µM -0.789336120037026 0.205309894512087 no 2714 0.21495779045184 3809 3000039 SGTC_1106 tegaserod maleate 11.7 µM -0.789477864445034 0.205268646758493 no 2715 0.214916381161545 3842 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.789689451481874 0.20520708389566 no 2716 0.214854576627687 3862 521171 SGTC_1266 0828-0227 32.9 µM -0.790590988954251 0.204944897669408 no 2717 0.214591353444195 3853 3913820 SGTC_1914 st062367 72.6 µM -0.790838101142791 0.204873066992751 no 2718 0.214519236490497 3834 978205 SGTC_317 4495-0002 170 µM -0.791036792786241 0.204815322079801 no 2719 0.21446126075693 3843 15991618 SGTC_3283 9109332 35.8195 µM -0.791815785858682 0.204589019996953 no 2720 0.214234048229292 3685 17027281 SGTC_1689 st020265 53.493 µM -0.793165591973627 0.204197245789132 no 2721 0.213840675754861 3798 5758320 YPR016C TIF6 SGTC_1019 4262-0212 3.4 µM -0.794395050186116 0.203840791041305 no 2722 0.2134827424327 3863 4677213 SGTC_2999 9069765 71.4286 µM -0.794413366466018 0.20383548343844 no 2723 0.213477412637997 3840 2097066 SGTC_2754 granisetron 64.02 µM -0.794948793955046 0.203680366255569 no 2724 0.213321644606111 3803 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2510 benzyl isothiocyanate 8.31 µM -0.795368168043385 0.203558919742321 no 2725 0.213199685438986 3800 2346 DNA damaging agent; causes G2/M arrest. SGTC_2926 9010726 65.15 µM -0.79669513649494 0.20317492766911 no 2726 0.212814054612403 3855 2994293 SGTC_682 0kpi-0099 17 µM -0.79785792231007 0.202838801736661 no 2727 0.212476471923716 3874 1714895 YML126C ERG13 SGTC_1766 st045414 44.774 µM -0.800706972114299 0.202016633650205 no 2728 0.211650652656227 3866 253960 SGTC_624 k048-0052 28 µM -0.802590595521835 0.201474161582402 no 2729 0.211105702914727 3822 6835531 SGTC_3210 9128157 49.47 µM -0.80393334138929 0.201087992408549 no 2730 0.210717736608485 3918 17590849 SGTC_644 1498-1197 63.3 µM -0.804348988634426 0.200968543703472 no 2731 0.210597726390417 3910 6741615 SGTC_1065 prochlorperazine maleate 2.48 µM -0.80561060064884 0.200606242420905 no 2732 0.210233705678343 3882 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1802 st050112 57.9 µM -0.805783138148763 0.200556724759411 no 2733 0.210183951106915 3842 4662563 SGTC_520 3584-0023 682 µM -0.810996217700848 0.199064052580989 no 2734 0.208683921411672 3869 1340790 SGTC_3123 9126162 49.47 µM -0.811060911034602 0.199045570948522 no 2735 0.208665346051814 3928 25239884 SGTC_1500 4488-1866 171 µM -0.811193269193964 0.199007762007486 no 2736 0.208627345166202 3946 2900003 SGTC_1934 st074720 32.6 µM -0.812410152894358 0.19866035435839 no 2737 0.208278161180619 3795 17250992 SGTC_3278 9139605 49.47 µM -0.816415989329563 0.197519315893624 no 2738 0.207131127361098 3884 7958859 SGTC_1892 st058411 7.36 µM -0.81817933723292 0.197018295365907 no 2739 0.206627395962107 3868 3934738 SGTC_2471 5466956 24.79 µM -0.818301325585753 0.196983663252631 no 2740 0.206592574691715 3818 724419 SGTC_1011 4112-3381 17.4 µM -0.818383410903909 0.19696036156074 no 2741 0.206569145599141 3956 2877139 SGTC_2848 9016370 25.97 µM -0.821247360796149 0.19614841253509 no 2742 0.205752692268062 3831 7894410 SGTC_865 0488-0499 301 µM -0.824647079723862 0.195187208787682 no 2743 0.204785992193539 3815 9634651 SGTC_3037 9091026 49.47 µM -0.825760074207808 0.194873154480937 no 2744 0.20447010335534 3864 25236398 YIL048W NEO1 SGTC_2302 7771753 200 µM -0.826846208127187 0.194566975890918 no 2745 0.204162117820247 3886 2203047 SGTC_581 0958-0271 211 µM -0.827290576790631 0.194441793847553 no 2746 0.204036191756095 3882 4591145 SGTC_1915 st067105 30.6 µM -0.827957097573356 0.194254121801489 no 2747 0.203847398567814 3841 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_866 0495-0101 262 µM -0.82837216884247 0.194137306071877 no 2748 0.203729881524448 3835 635694 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.82881643031099 0.194012322609704 no 2749 0.203604144767646 3929 5393153 SGTC_2733 amorolfine 100 µM -0.82971822070178 0.193758773977564 no 2750 0.20334905859552 3904 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2576 guaiol 23.12 µM -0.830676120762244 0.193489670840741 no 2751 0.203078309854668 3862 227829 SGTC_766 1391-0721 126 µM -0.83273274935837 0.192912672304811 no 2752 0.202497735084389 3925 1020919 YIL115C NUP159 SGTC_3168 9103419 49.47 µM -0.834903001662791 0.192304936976154 no 2753 0.201886162289423 3831 16649256 SGTC_296 1222-0039 74.9 µM -0.835824796944843 0.192047161506425 no 2754 0.201626737146076 3868 5984176 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.836003049934745 0.191997338352313 no 2755 0.201576593627992 3907 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2481 5478948 45.16 µM -0.836396236577179 0.191887467474045 no 2756 0.201466014543753 3935 77792 SGTC_2049 5262831 67.185 µM -0.836863709031266 0.191756888488916 no 2757 0.20133459076772 3936 763417 SGTC_1658 st012944 20 µM -0.837281638196096 0.191640194498851 no 2758 0.201217138961432 3791 24207260 SGTC_595 3909-8003 73.7 µM -0.839100943846713 0.191132715775137 no 2759 0.20070633325164 3967 699517 SGTC_1534 6-azauridine 81.6 µM -0.839128943750472 0.191124911901184 no 2760 0.200698477817061 3918 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1574 spiramycin 23.7 µM -0.839672576142882 0.190973434437009 no 2761 0.200545997134782 3862 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2376 9072922 81.32 µM -0.841562018040599 0.190447534247161 no 2762 0.200016578507244 3938 17087968 SGTC_363 0455-0021 3.06 µM -0.842427630223103 0.190206900316035 no 2763 0.19977431626191 3884 4597466 SGTC_1138 3761-0006 1.03 µM -0.845406595481341 0.18938019812255 no 2764 0.198941931653179 3850 12061087 SGTC_26 0302-0163 425.158 µM -0.845409810677438 0.189379307059623 no 2765 0.198941034391469 3951 3100915 SGTC_3245 9134821 49.47 µM -0.847056501891531 0.188923280429024 no 2766 0.198481814396977 3898 17014901 SGTC_2459 5811157 9.22 µM -0.847731275154162 0.188736607598254 no 2767 0.198293822288168 3870 2870684 YBR192W RIM2 SGTC_926 2268-1401 59.4 µM -0.849396170399212 0.188276508728812 no 2768 0.197830441699028 3878 2931578 SGTC_1440 4100-1550 40 µM -0.849432405354697 0.188266502788992 no 2769 0.197820363914752 3899 742806 SGTC_1803 st050068 52.4 µM -0.849599365694569 0.188220402511043 no 2770 0.197773932366612 3963 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_576 1073-0113 22.7 µM -0.850243057666699 0.188042734612968 no 2771 0.197594983744648 4053 5439563 SGTC_1407 3909-7909 12.3 µM -0.850870291583705 0.187869708987162 no 2772 0.197420704707181 3883 4411780 SGTC_635 k038-0028 24.7 µM -0.854126227990497 0.186973123196054 no 2773 0.196517526485201 3908 4035102 SGTC_965 1291-5240 308 µM -0.854389977831427 0.186900610610604 no 2774 0.196444473566335 3906 2834598 SGTC_2193 5925765 200 µM -0.854615769309028 0.186838547722583 no 2775 0.196381947358537 3888 877370 SGTC_134 0269-0018 6.916 µM -0.855203277722529 0.18667712014444 no 2776 0.196219310983144 3874 4378915 SGTC_406 estrone 100 µM -0.857102282696743 0.186155928232088 no 2777 0.195694179872833 3875 5870 A steroid. SGTC_1372 2752-0194 270 µM -0.857834891176984 0.185955101289511 no 2778 0.195491820194893 3869 823334 SGTC_628 1636-0253 16 µM -0.858198377460909 0.185855510172402 no 2779 0.195391465911801 3924 4456143 SGTC_2585 alliin 100 µM -0.860306126472036 0.185278663128824 no 2780 0.194810158317047 3966 87310 A garlic compound which reacts with lipids. SGTC_1492 4158-0558 28.5 µM -0.861488211101798 0.18495563828428 no 2781 0.194484605641465 3919 3967268 SGTC_71 0417-1750 47.813 µM -0.861810460015801 0.184867638995477 no 2782 0.194395913973605 3888 6811472 SGTC_2836 9010338 19.48 µM -0.861965790835252 0.184825230765477 no 2783 0.194353171502828 3928 2994051 SGTC_503 tyrphostin 8 294 µM -0.862985914147776 0.184546868225595 no 2784 0.194072605794666 3888 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.863104725803148 0.184514464875768 no 2785 0.194039944936407 3957 279621 SGTC_2153 5569715 200 µM -0.863796446908879 0.184325882949632 no 2786 0.193849860029241 3939 2054701 SGTC_1443 4112-3303 14 µM -0.864124412822357 0.184236512474663 no 2787 0.193759774699073 3937 704433 SGTC_24 0417-1663 219 µM -0.864376437943929 0.184167854137056 no 2788 0.193690566050198 3896 4329390 SGTC_2435 5706476 10.6 µM -0.864884127983472 0.18402959424545 no 2789 0.193551194999787 3933 5725375 SGTC_2102 5377816 72.7585 µM -0.86498974297303 0.184000840099588 no 2790 0.193522209264473 3961 1379702 SGTC_645 0845-0943 5.41 µM -0.865316251462209 0.18391196441907 no 2791 0.193432616679432 3923 1885106 SGTC_501 nsc-95397 161 µM -0.865337790596029 0.183906102402358 no 2792 0.193426707319646 3967 262093 SGTC_98 0074-0023 107.663 µM -0.866161155246075 0.183682105553071 no 2793 0.193200896049732 3920 3563821 SGTC_1145 3546-0597 10.2 µM -0.869467677909927 0.182784277191581 no 2794 0.192295689829922 3903 875334 SGTC_2092 5303694 80.6725 µM -0.870747270095354 0.182437562803794 no 2795 0.191946081090059 3926 1963699 SGTC_1945 st075991 56.6 µM -0.870809777852732 0.18242063642461 no 2796 0.19192901276321 3963 1084980 SGTC_2990 9074105 71.4286 µM -0.871444310139559 0.182248867938414 no 2797 0.191755800383375 3871 6502001 SGTC_426 0988-0037 14.6 µM -0.873033428508378 0.181819135841684 no 2798 0.191322428689384 3932 5383008 SGTC_1862 st057513 3.81 µM -0.873197199393764 0.181774884694748 no 2799 0.191277800544932 3902 5393163 SGTC_1014 4130-3005 69.3 µM -0.874774841092561 0.181348948590075 no 2800 0.190848214492695 3950 743608 SGTC_2533 agelasine 13.65 µM -0.881291396241118 0.179596220474259 no 2801 0.189080060840789 4009 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1337 1486-1011 40.3 µM -0.882895626253332 0.179166376449181 no 2802 0.188646333478596 3927 X1337 SGTC_2495 cafestol 54.53 µM -0.883097472095652 0.17911233890927 no 2803 0.188591804937048 3973 16667697 An anti-infammatory. SGTC_1147 3809-1045 12.3 µM -0.884459721290599 0.178747909946423 no 2804 0.188224048236991 3920 325925 SGTC_370 0180-0345 38.7 µM -0.885027211343247 0.178596232819226 no 2805 0.188070977647516 3836 3989527 SGTC_263 alizarin 107.927 µM -0.88642052010489 0.178224177144443 no 2806 0.187695482830689 3957 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1368 1852-0141 284 µM -0.887267639112809 0.177998209653624 no 2807 0.187467411954838 3965 2838987 SGTC_1637 st007924 17.4 µM -0.887274807740616 0.177996298206057 no 2808 0.187465482667632 3902 683336 SGTC_2678 equilin 100 µM -0.88810630676631 0.177774674588234 no 2809 0.187241785249929 3957 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_471 1-acyl-paf 4 µM -0.892377226840303 0.176639069926543 no 2810 0.186095386639444 3885 16759367 SGTC_3217 9129673 49.47 µM -0.892907858181659 0.176498300200094 no 2811 0.185953259270809 3976 17248312 SGTC_115 0527-0192 112.043 µM -0.893981067097679 0.17621380852049 no 2812 0.185666010574096 3980 4233931 SGTC_3119 9125183 49.47 µM -0.897120628085904 0.175383225222171 no 2813 0.184827276264156 3784 22695334 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.899220569402402 0.17482906501032 no 2814 0.184267593070601 3971 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2690 usnic acid 100 µM -0.900046458447194 0.174611423345122 no 2815 0.184047763697671 3976 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2986 9022445 71.43 µM -0.900671080273528 0.174446934754616 no 2816 0.183881614711037 3983 6459286 SGTC_1027 k015-0025 8.67 µM -0.904080733500486 0.173550768870925 no 2817 0.182976296849457 3962 3598955 SGTC_2324 6149169 200 µM -0.905215395463217 0.173253194279985 no 2818 0.182675643646121 3891 2888231 SGTC_391 gliotoxin 8.33 µM -0.907739478746988 0.172592398358452 no 2819 0.182007940309972 4071 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_259 usnic acid 108.925 µM -0.908541291995997 0.172382823306312 no 2820 0.18179615401864 4063 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1157 4092-0394 27.6 µM -0.909614522890516 0.172102560265019 no 2821 0.181512918423495 4079 3659885 SGTC_537 1334-0398 209 µM -0.909816163292839 0.17204993645135 no 2822 0.181459734487901 3987 5846986 SGTC_2279 7948423 32.93 µM -0.910123143377964 0.171969840967139 no 2823 0.181378785274959 3912 1247112 SGTC_450 aminopyrene 156 nM -0.913238690427138 0.171158297479417 no 2824 0.180558509672046 3883 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2195 6536160 144.242 µM -0.916894017024124 0.170209278937652 no 2825 0.179599089720419 3925 3834386 SGTC_2692 st077426 47.7 µM -0.918041709051909 0.169912004833346 no 2826 0.179298515085977 4012 25238571 SGTC_1284 0929-0043 16 µM -0.919061804090657 0.169648060366736 no 2827 0.179031623141954 3957 1239883 SGTC_3074 9116018 49.47 µM -0.919203225678843 0.169611489011005 no 2828 0.178994642129903 4052 17027303 SGTC_2215 7188065 200 µM -0.919400523437857 0.169560476633252 no 2829 0.178943057820085 4003 940217 SGTC_933 2914-0560 114 µM -0.922488906054873 0.168763242240599 no 2830 0.178136807205346 4055 463887 SGTC_3205 9113483 49.47 µM -0.924265454381486 0.168305737586158 no 2831 0.177674062107763 4070 17018033 SGTC_2864 9034755 47.6 µM -0.92512311416027 0.1680851550062 no 2832 0.177450935536341 3949 4930451 SGTC_1611 st001856 99.4 µM -0.925294547141514 0.168041086264369 no 2833 0.177406357192064 3973 647478 SGTC_2382 9035899 200 µM -0.928781978023383 0.167146218076886 no 2834 0.176501043022169 3992 6462679 SGTC_1631 benzylvanillin 81.9 µM -0.929085419922303 0.167068501014124 no 2835 0.176422409923531 4090 75506 SGTC_140 0062-0056 502.533 µM -0.929119510793785 0.167059771169806 no 2836 0.176413577093887 3942 3758964 SGTC_2884 9058502 51.95 µM -0.929455439991857 0.166973763590239 no 2837 0.176326553934948 4045 6471554 SGTC_2402 5553605 200 µM -0.929652709157358 0.166923270296052 no 2838 0.176275463607309 4098 6758546 SGTC_2296 7971656 126.45 µM -0.931924230258627 0.166342558285897 no 2839 0.175687842229547 4057 666570 SGTC_2177 5811945 192 µM -0.933700931034117 0.165889256946383 no 2840 0.175229092311406 4054 5343475 SGTC_859 0439-0102 54.6 µM -0.937531340751688 0.164914698258575 no 2841 0.174242655109411 4011 610143 SGTC_1620 st003704 16.5 µM -0.937707932813029 0.164869858102479 no 2842 0.174197262989969 3936 2834414 SGTC_2802 7925815 54.55 µM -0.938150964088069 0.164757398610354 no 2843 0.174083417064132 3984 1262923 SGTC_2298 7976326 193.81 µM -0.938601862855505 0.16464299306312 no 2844 0.173967598001209 3896 2235818 SGTC_1164 k060-0068 93.7 µM -0.942202149836301 0.163731347148387 no 2845 0.173044576733918 4025 5963676 SGTC_718 1130-0073 349 µM -0.942323351169446 0.163700714297869 no 2846 0.173013558196892 4066 6740020 SGTC_3115 9123671 49.47 µM -0.942424625212807 0.16367512079397 no 2847 0.172987642282299 4118 3286988 SGTC_2020 4017018 200 µM -0.942721011710842 0.163600234307116 no 2848 0.172911811519915 4110 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1418 3966-3099 2.4 µM -0.94536867269301 0.162932250335909 no 2849 0.172235344981249 4019 740335 SGTC_1573 oleylamine 1.06 µM -0.946312729043243 0.162694501835783 no 2850 0.171994551412656 4024 5356789 An amine of the fatty acid oleic acid. SGTC_53 0973-0023 39.979 µM -0.94833506281029 0.162185962849395 no 2851 0.171479453182236 3906 674768 SGTC_458 nppb 133 µM -0.950555924628745 0.161628695414497 no 2852 0.170914925918359 4046 4549 A chloride channel blocker. SGTC_1844 rapamycin 4 nM -0.950619079217887 0.16161286668785 no 2853 0.170898889878441 3938 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1485 3909-9022 254 µM -0.951464638188675 0.161401037671876 no 2854 0.170684280599408 4056 714516 SGTC_3147 9097027 49.47 µM -0.952839759588519 0.161056929790843 no 2855 0.170335632936107 4041 25236841 SGTC_1963 st076565 50.3 µM -0.952909735994736 0.161039431832847 no 2856 0.170317903355676 4044 4914280 SGTC_914 3820-6779 408 µM -0.952910898165798 0.161039141236507 no 2857 0.170317608912047 3985 2893481 SGTC_70 0141-0289 43.283 µM -0.953675172782984 0.160848111463055 no 2858 0.17012404556574 4031 352408 SGTC_1270 0831-1170 17.3 µM -0.954637612027208 0.160607761152644 no 2859 0.169880494851215 4015 6764716 SGTC_2677 mitomycin C 100 µM -0.954701330985989 0.160591856877094 no 2860 0.169864378300943 4062 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3051 9093778 49.47 µM -0.95862530998432 0.159614412725817 no 2861 0.168873768685714 4071 17217378 SGTC_1236 0330-0013 258 µM -0.96234160312448 0.158692299473095 no 2862 0.167939018633402 4055 4617066 SGTC_1539 benzyladenosine 56 µM -0.9630948321103 0.158505829446346 no 2863 0.167749967493225 4029 92208 A nucleotide analog. SGTC_2113 5491891 107.031 µM -0.96327716864442 0.158460711667714 no 2864 0.167704223892859 4059 789979 SGTC_3096 9117468 49.47 µM -0.963686822882018 0.158359376590592 no 2865 0.167601481360889 3945 41316311 SGTC_385 1494-0393 12.4 µM -0.964543991989545 0.158147478532431 no 2866 0.167386631936874 4037 3090647 SGTC_680 0417-1641 114 µM -0.965496889267239 0.157912134346997 no 2867 0.167147996659977 4023 2835990 SGTC_325 2810-4341 181 µM -0.965559110642989 0.157896775069803 no 2868 0.167132422114059 4050 774970 SGTC_1155 4088-0394 48.2 µM -0.966513931288034 0.15766120169367 no 2869 0.16689353963754 4031 2326248 SGTC_861 0443-0273 110 µM -0.967905805130964 0.157318212369879 no 2870 0.166545707429144 4058 6149169 SGTC_2015 5119600 184 µM -0.970336617190516 0.156720382349934 no 2871 0.165939365447975 4100 2828786 SGTC_2090 5301565 104.445 µM -0.970936156678121 0.156573162745669 no 2872 0.165790035868204 4065 2056344 SGTC_3039 9090270 49.47 µM -0.970936962616539 0.156572964905181 no 2873 0.165789835188545 4069 17173750 SGTC_1717 st033143 58.0435 µM -0.970985876686957 0.156560957864691 no 2874 0.165777655818734 4120 674616 SGTC_875 0709-0210 25.7 µM -0.9728051805335 0.156114800089569 no 2875 0.165325068730465 4070 6251364 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.974244271020015 0.155762478146712 no 2876 0.164967633971572 4034 15053 SGTC_1483 3453-0561 55.9 µM -0.975406775972407 0.155478253736305 no 2877 0.164679261929002 4070 4546991 SGTC_160 3453-0671 289.699 µM -0.979708403780917 0.154429512933415 no 2878 0.163615038324979 4108 5322268 SGTC_1865 st057639 52.2 µM -0.981301416298167 0.154042324422802 no 2879 0.163222062266174 4047 688818 SGTC_2845 9003024 42.97 µM -0.98209384458393 0.153849960748356 no 2880 0.16302680883583 4151 2990173 SGTC_44 0929-0055 61.211 µM -0.98361421665037 0.153481332483154 no 2881 0.162652616173308 3980 1379590 SGTC_3247 9135149 49.47 µM -0.983985194371694 0.153391474362849 no 2882 0.162561396321493 4057 8934436 YOR116C RPO31 SGTC_489 paxilline 115 µM -0.984746738521343 0.153207122571431 no 2883 0.16237424426253 4071 105008 A toxic potassium channel blocker. SGTC_3314 9135860 59.4275 µM -0.985405078241095 0.153047872499816 no 2884 0.162212568108845 4081 25252478 SGTC_3055 9094636 49.47 µM -0.98545983808055 0.153034631231355 no 2885 0.162199124820542 4104 25236176 SGTC_2980 9014342 25.29 µM -0.986287569396389 0.15283457316807 no 2886 0.161996008953447 4142 2996599 SGTC_2350 9023895 38.85 µM -0.989260247722831 0.152117523795778 no 2887 0.161267914029691 4098 2997209 SGTC_2888 9058547 12.99 µM -0.989307126600061 0.152106233912168 no 2888 0.161256449159946 3978 16476514 SGTC_2473 5854593 8.94 µM -0.989830358178153 0.151980261330243 no 2889 0.161128521816606 3975 2872951 SGTC_245 methotrexate 289.6 µM -0.993113870597681 0.151191309336695 no 2890 0.160327232584718 4060 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3272 9137413 49.47 µM -0.996070087725052 0.150483333652072 no 2891 0.15960804617051 4017 17614870 SGTC_660 4031-1742 102 µM -0.996438329729853 0.150395299398529 no 2892 0.159518608623197 3994 6738706 SGTC_1153 4055-0057 267 µM -0.996695994009975 0.150333720961366 no 2893 0.159456047383608 4134 882706 SGTC_838 0109-0203 71.4 µM -0.99736692902391 0.150173454993978 no 2894 0.159293218821392 4087 759422 SGTC_351 caspofungin 25 nM -0.997571222403239 0.150124678145476 no 2895 0.159243660693426 4087 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_797 k781-0471 270 µM -0.998666757439381 0.149863289667246 no 2896 0.15897807465555 4052 23738129 SGTC_118 0083-0097 135.343 µM -0.999704182332966 0.149616045919774 no 2897 0.158726843733873 4100 5207356 SGTC_2906 7926292 26.41 µM -1.00072667620548 0.149372627078431 no 2898 0.158479483450846 4115 2966319 SGTC_2600 tangeritin 87.95 µM -1.00779279346988 0.147697669257442 no 2899 0.156776973129599 4031 68077 A bioactive flavone. SGTC_1079 idarubicin 2.36 µM -1.00797482870024 0.147654686337363 no 2900 0.156733273185615 4112 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2775 cyproheptadine 69.59 µM -1.00919030295274 0.147367898222107 no 2901 0.156441688149395 4095 2913 A selective serotonin reuptake inhibitor. SGTC_2363 9053361 176 µM -1.00953788935094 0.147285954761891 no 2902 0.156358369967984 4173 6469797 YMR079W SEC14 SGTC_3281 9140613 49.47 µM -1.01089758325914 0.14696570048896 no 2903 0.156032725428466 4106 16013766 SGTC_260 nsc-65238 3.989 µM -1.01119280534411 0.146896227376493 no 2904 0.155962079309249 4090 3246252 SGTC_3275 9138069 49.47 µM -1.01292990823564 0.146487889962918 no 2905 0.155546820744181 4179 17617007 SGTC_1343 1487-0095 224 µM -1.0141911549501 0.146191889025666 no 2906 0.155245774177404 4117 4560101 YGL055W OLE1 SGTC_3268 9137683 49.47 µM -1.0167679283604 0.145588397741363 no 2907 0.15463192122716 4154 1953228 SGTC_1783 st039459 87.517 µM -1.01877844005091 0.145118692364096 no 2908 0.154154081734524 4214 729761 SGTC_1912 st060209 90.8 µM -1.0199474213804 0.144846058737409 no 2909 0.153876698777768 4120 688787 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.02040278685837 0.144739950320798 no 2910 0.153768736359191 4252 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1216 1165-0504 9.65 µM -1.02379774372392 0.143950514064878 no 2911 0.152965408160017 4151 6304004 SGTC_2717 st081029 62.2815 µM -1.02480040478159 0.143717919800593 no 2912 0.152728687694551 4086 5292846 SGTC_2779 methotrexate 400 µM -1.02681963761276 0.143250274304892 no 2913 0.152252700330583 4131 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2156 5649887 115 µM -1.02686880157797 0.143238900976124 no 2914 0.152241123359402 4161 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3166 9102297 49.47 µM -1.02895145689036 0.142757670723176 no 2915 0.151751243188914 4128 25237072 SGTC_2008 4012253 172 µM -1.0301192693349 0.142488308086688 no 2916 0.151477010353332 4108 603940 SGTC_1268 0828-0275 2.46 µM -1.03200019459161 0.142055185020206 no 2917 0.15103601317229 4169 745337 SGTC_1887 st057648 70.8 µM -1.03456405263516 0.141466238811273 no 2918 0.150436274530606 4122 688672 SGTC_1866 st057638 64 µM -1.03555477891659 0.141239102013163 no 2919 0.150204949041065 4097 688802 SGTC_2698 st077697 67.5 µM -1.03609615423188 0.141115089248371 no 2920 0.15007864310209 4099 3154499 SGTC_523 1934-0222 13.7 µM -1.03629349560408 0.141069902657312 no 2921 0.150032619852615 4085 1361595 SGTC_1849 st056239 19.2 µM -1.03715114008184 0.140873635987618 no 2922 0.149832712396714 4131 5393181 SGTC_10 0279-0212 42.575 µM -1.0377771631637 0.140730491463521 no 2923 0.149686905550089 4109 39851 YBR002C RER2 SGTC_713 1488-1073 324 µM -1.03920574123548 0.140404206887694 no 2924 0.149354530467356 4064 3312542 SGTC_2239 6685329 187.64 µM -1.04129747530453 0.139927386046671 no 2925 0.148868754047513 4191 805680 SGTC_2437 5741531 144.16 µM -1.04188568839492 0.139793498523127 no 2926 0.148732340066917 4166 2262990 SGTC_1903 st060211 78.3 µM -1.0448315810306 0.139124272605143 no 2927 0.148050408009193 4165 688960 SGTC_1779 st039427 55 µM -1.04489472948347 0.139109950923388 no 2928 0.148035812990144 4086 1124498 SGTC_1702 st027038 51 µM -1.04569467631243 0.138928614759241 no 2929 0.147851010760747 4162 5521182 SGTC_2504 purpurogallin 52.29 µM -1.04645146956267 0.138757209094456 no 2930 0.147676320034656 4034 5281571 An antioxidant. SGTC_405 ebelactone b 50 µM -1.04668601278219 0.138704116785481 no 2931 0.147622208451036 4099 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2711 st079103 59.1 µM -1.04725162833165 0.138576138310916 no 2932 0.147491769642246 4093 54693780 SGTC_2021 4019055 173 µM -1.0475074525734 0.138518280908895 no 2933 0.147432798384448 4007 44827708 YER133W GLC7 SGTC_1400 3771-8998 51.5 µM -1.04791509254952 0.138426122761378 no 2934 0.147338864010824 4043 670767 SGTC_3330 9141424 71.43 µM -1.04973500202568 0.13801519231502 no 2935 0.146919983152777 4220 27261020 SGTC_1172 0370-0043 85 µM -1.04992697691402 0.1379718934866 no 2936 0.146875843722775 4167 376585 SGTC_700 3453-2283 142 µM -1.05152834205606 0.137611075820815 no 2937 0.146507999725101 4195 565664 SGTC_174 3553-0389 74.3 µM -1.05190665094767 0.137525929849804 no 2938 0.146421190086725 4229 738071 SGTC_1986 st071812 45 µM -1.05241868091747 0.137410744570881 no 2939 0.146303750800359 4089 11838594 SGTC_796 1234-0020 70.7 µM -1.05470515226093 0.136897188347395 no 2940 0.145780097332431 4075 46495034 SGTC_1850 st056238 17 µM -1.05812754121664 0.136130951653034 no 2941 0.144998649897489 4167 5393177 SGTC_2778 tioconazole 65.09 nM -1.05845472704358 0.136057852235018 no 2942 0.144924090231349 4043 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2620 irigenin 100 µM -1.06049798495522 0.135601958175959 no 2943 0.144459053105881 4189 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1053 3366-3204 134 µM -1.06192145957287 0.135284970074891 no 2944 0.144135671031898 4184 3632071 YPR165W RHO1 SGTC_1181 1222-0449 220 µM -1.06355365035338 0.134922129361067 no 2945 0.143765474380648 4226 658318 SGTC_1512 0259-0544 12.2 µM -1.06369790358261 0.134890093588899 no 2946 0.14373278723629 4124 18476 SGTC_2703 st077852 53.4 µM -1.0640441609797 0.134813218006464 no 2947 0.143654347306873 4206 6281836 SGTC_1354 1498-1681 81 µM -1.07206485486417 0.133040884533511 no 2948 0.141845451576294 4177 5754243 SGTC_629 3448-6466 76.7 µM -1.07370461754846 0.132680529725859 no 2949 0.141477545579968 4168 573744 SGTC_3005 9076496 71.4286 µM -1.0740462755296 0.132605531565006 no 2950 0.141400970828146 4137 21368410 SGTC_1289 0976-0073 69.1 µM -1.07488154133007 0.132422303360502 no 2951 0.141213883570932 4221 3391136 SGTC_964 1287-0107 19.4 µM -1.07652389195463 0.13206253786015 no 2952 0.140846510777125 4185 51516812 YPR165W RHO1 SGTC_96 0929-0093 37.281 µM -1.07771242604646 0.131802603991754 no 2953 0.140581055684654 4171 6991579 SGTC_3021 9087658 49.47 µM -1.07899852866976 0.131521729631561 no 2954 0.140294191777483 4183 25237042 SGTC_1746 st038117 42 µM -1.08414011145549 0.130402978748728 no 2955 0.139151340198984 4230 2898218 SGTC_2975 9084847 53.72 µM -1.08433242867591 0.130361260768414 no 2956 0.139108715941285 4235 27211724 SGTC_2291 7917025 104.35 µM -1.08560357209684 0.130085753017232 no 2957 0.13882720936648 4095 2964612 SGTC_125 0133-0007 11.75 µM -1.08924704654818 0.129298299912388 no 2958 0.138022478663473 4264 26541 SGTC_1421 4029-0249 71.4 µM -1.0917910791246 0.128750428449699 no 2959 0.137462470515154 4260 2894095 SGTC_824 1304-0008 100 µM -1.09423571245614 0.128225482576998 no 2960 0.136925806194635 4207 768245 SGTC_451 chloral hydrate 100 µM -1.09509977608209 0.128040294756712 no 2961 0.136736463391561 4211 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1680 diphenhydramine 100 µM -1.09993468162544 0.127007497022743 no 2962 0.135680291207689 4177 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3129 9127257 49.47 µM -1.10372798728692 0.12620126770227 no 2963 0.13485557562846 4145 837894 SGTC_1994 st072947 40.9 µM -1.10415577965362 0.12611056902768 no 2964 0.134762784078352 4245 5286565 YDL195W SEC31 SGTC_1344 1488-0097 29.1 µM -1.10442898443041 0.126052669123021 no 2965 0.134703546728828 4236 747966 SGTC_854 0422-0053 192 µM -1.10531570815554 0.125864874713539 no 2966 0.134511406880054 4208 3596728 SGTC_60 0986-0278 202 µM -1.1055085745155 0.125824054442153 no 2967 0.134469640530546 4155 3110598 SGTC_2726 cimetidine 79.27 µM -1.10609649582251 0.125699677552604 no 2968 0.134342377639658 4187 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_535 2293-4129 48.2 µM -1.10980716809587 0.124916650404769 no 2969 0.133541064896855 4212 396118 YIL048W NEO1 SGTC_864 0469-0573 172 µM -1.1106803528472 0.124732887071185 no 2970 0.133352981017163 4194 689425 SGTC_1933 st074711 15.9 µM -1.11590522136963 0.123637251395195 no 2971 0.132231353289434 4198 17250958 SGTC_593 1203-0218 61.7 µM -1.11966440305706 0.122853145056612 no 2972 0.131428399835672 4233 3666956 SGTC_219 mitoxanthrone 164.414 µM -1.11995012088629 0.122793691712572 no 2973 0.131367509039789 4150 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2204 7233102 200 µM -1.11998675033021 0.122786071166337 no 2974 0.131359704159514 4131 2172480 SGTC_2377 9073351 62.6 µM -1.12422291653051 0.12190699732591 no 2975 0.13045923494846 4180 7337946 YHR072W ERG7 SGTC_429 1112-0049 25.5 µM -1.12537285099919 0.12166913189765 no 2976 0.130215535285475 4190 2836170 SGTC_1481 3346-2004 36 µM -1.12575098936778 0.121590984795511 no 2977 0.130135467240653 4284 2770522 SGTC_2068 5226020 147 µM -1.12587862312291 0.121564615622021 no 2978 0.130108449415134 4240 1810509 SGTC_330 1488-0319 80.1 µM -1.12967569257601 0.120781977781593 no 2979 0.129306451648693 4253 6846614 SGTC_285 1486-1325 46 µM -1.13194490522942 0.120315952679502 no 2980 0.128828799014244 4267 22310230 SGTC_1839 st053978 48 µM -1.13553825622959 0.119580584710552 no 2981 0.128074931149669 4237 3788398 SGTC_2052 5265182 7.135 µM -1.13976423266709 0.118719815705802 no 2982 0.127192269335074 4231 1239884 SGTC_1473 k844-0725 134 µM -1.14041637012463 0.118587375783729 no 2983 0.127056438006004 4279 54682906 SGTC_2732 terfenadine 20 µM -1.14155272389519 0.11835684788518 no 2984 0.126819992305989 4295 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_264 promethazine 12.5 mM -1.14275649307001 0.118112989414806 no 2985 0.126569853546318 4109 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_167 3672-0051 66.205 µM -1.14566589174524 0.117525073929068 no 2986 0.125966710949683 4141 3237971 SGTC_2093 5331342 194.4 µM -1.14710571735229 0.117234889408945 no 2987 0.125668965606967 4290 33839 SGTC_187 1488-2104 32.728 µM -1.14793985973105 0.117067007528231 no 2988 0.125496695901009 4257 2852859 SGTC_2645 abamectin 100 µM -1.15306290935563 0.116039663382809 no 2989 0.124442282078174 4205 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1788 fluconazole 20 µM -1.15454701357301 0.115743249582584 no 2990 0.124137987815894 4277 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_652 0437-0092 114 µM -1.15638896205822 0.115376113491158 no 2991 0.12376104721098 4191 3091274 SGTC_41 0478-0632 82.643 µM -1.15675586272895 0.115303082023323 no 2992 0.123686059611801 4211 3750424 SGTC_3164 9100705 49.47 µM -1.15765572971933 0.115124102908622 no 2993 0.123502278431068 4263 17174235 SGTC_188 3229-0966 278.469 µM -1.16085702147253 0.114488983361538 no 2994 0.122850024714768 4286 5722370 SGTC_518 1021-0119 62.6 µM -1.160997104667 0.114461248658189 no 2995 0.122821538447054 4220 1097762 SGTC_545 4218-0007 221 µM -1.16410343853578 0.113847462337449 no 2996 0.122191047667916 4232 2840508 SGTC_3235 9132602 49.47 µM -1.16539297225149 0.113593351145586 no 2997 0.121929980356596 4250 4912240 SGTC_544 k015-0020 52.4 µM -1.16565029113817 0.113542693182242 no 2998 0.121877932831219 4257 3008304 SGTC_1016 4226-1401 38 µM -1.16668702382349 0.113338756447247 no 2999 0.121668392504293 4226 2901613 SGTC_403 arphamenine a 50 µM -1.16717709090332 0.113242445852164 no 3000 0.121569430247144 4232 5487158 An arginine aminopeptidase inhibitor. SGTC_20 0481-0013 4.944 µM -1.17109691555917 0.112474201737888 no 3001 0.120779911770299 4301 182045 SGTC_611 3453-1652 23.7 µM -1.1714247981545 0.112410109373813 no 3002 0.120714034657822 4289 1560575 SGTC_2737 bleomycin 30.5 nM -1.17311133609525 0.112080848165894 no 3003 0.120375580569125 4340 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2163 5671233 125 µM -1.17794191078043 0.11114159659061 no 3004 0.119409882585605 4230 701023 SGTC_1174 0739-0097 51.1 µM -1.17929852876391 0.110878833899654 no 3005 0.119139661951104 4299 728447 SGTC_2476 5806916 10.51 µM -1.17963564807502 0.110813606515253 no 3006 0.119072579191914 4150 2870194 SGTC_410 α-linolenic acid 100 µM -1.18155585132687 0.110442601066788 no 3007 0.118690989973729 4307 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2759 disulfiram 3.38 µM -1.18395759250352 0.109979811575905 no 3008 0.118214925128406 4174 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_931 2812-0076 566 µM -1.18438061403523 0.109898444247652 no 3009 0.118131215306483 4218 3450959 SGTC_697 0508-1955 564 µM -1.18598292494775 0.109590634757652 no 3010 0.117814521377658 4273 6243113 SGTC_3033 9090887 49.47 µM -1.18736040536673 0.109326511232892 no 3011 0.117542745430098 4272 19325384 SGTC_1077 5-fluorocytosine 377 nM -1.18823484000389 0.109159081150075 no 3012 0.117370450549279 4333 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_282 k297-0036 65.7 µM -1.18851665043217 0.109105161515374 no 3013 0.117314961948017 4274 5061378 SGTC_2815 7968870 71.43 µM -1.19426712568801 0.10800908328263 no 3014 0.116186746388377 4227 2977326 YHR190W ERG9 SGTC_2865 9030313 51.95 µM -1.20122189564019 0.106694079717986 no 3015 0.114832569056968 4261 42562754 SGTC_1169 aniline yellow 25.8 µM -1.20247221003216 0.106458901638064 no 3016 0.114590313391155 4203 6051 A DNA damaging agent. SGTC_763 3453-1109 128 µM -1.20337656025508 0.106289031159613 no 3017 0.11441531712386 4311 1560353 SGTC_390 dec-rvkr-cmk 16.7 µM -1.20535372854481 0.105918327740279 no 3018 0.114033388102653 4334 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3116 9124943 49.47 µM -1.20556528622473 0.105878717754787 no 3019 0.113992575421925 4262 41905195 YPL160W CDC60 SGTC_2308 7584454 197.62 µM -1.20629357440527 0.105742442084067 no 3020 0.113852157181088 4343 893577 SGTC_1695 st026914 34.495 µM -1.20692446275372 0.10562449418899 no 3021 0.11373061787522 4284 3289191 SGTC_420 mitomycin C 81.9 mM -1.20755413842468 0.105506867894245 no 3022 0.113609404431563 4277 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.20845453144039 0.105338834991716 no 3023 0.113436237578576 4275 688667 SGTC_2329 6138490 200 µM -1.21073691948244 0.104913759360929 no 3024 0.112998123986902 4359 720019 SGTC_2413 inermin 26.06 µM -1.21109579499378 0.104847034949802 no 3025 0.112929346406852 4353 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2466 5983409 37.09 µM -1.21477339783537 0.104165041860983 no 3026 0.112226264790771 4301 2879657 SGTC_367 0335-0881 7.1 µM -1.21522660847536 0.104081219296775 no 3027 0.112139837285484 4251 23828853 SGTC_2801 7907800 81.82 µM -1.21564162467531 0.104004503806781 no 3028 0.112060735220545 4318 6620925 SGTC_3068 9116768 49.47 µM -1.21826886743097 0.103519810816738 no 3029 0.111560908358255 4277 41904888 SGTC_497 capsazepine 133 µM -1.21990965008496 0.103217940009771 no 3030 0.111249563599906 4251 2733484 A calcium channel blocker. SGTC_143 4032-1194 15.74 µM -1.22522908754556 0.10224366738117 no 3031 0.110244458938775 4339 1806963 SGTC_1092 toremifene 6.32 µM -1.22695581725329 0.101928853735042 no 3032 0.109919598804186 4296 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.23001522055765 0.10137280322676 no 3033 0.109345702624892 4282 756377 SGTC_1051 3253-3903 78 µM -1.23250113781754 0.100922614396035 no 3034 0.108880970930922 4305 5509239 SGTC_2335 9018011 154.17 µM -1.24041621185669 0.0994989402050126 no 3035 0.10741074384732 4307 6458208 SGTC_632 0781-2353 4.65 µM -1.24169044584628 0.0992711239186176 no 3036 0.107175398192421 4376 6811515 YHR007C ERG11 SGTC_1119 parthenolide 318.541 nM -1.24423752570143 0.0988168831024988 no 3037 0.10670607825451 4397 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_352 k048-0007 5.11 µM -1.24583041813753 0.0985335841249004 no 3038 0.106413329861224 4263 6811911 SGTC_432 NS 1619 61.3 µM -1.24676310991146 0.0983679793612318 no 3039 0.106242185321519 4313 4552 A K+/calcium channel activator. SGTC_1700 st030840 7.9285 µM -1.24737561130292 0.0982593371673724 no 3040 0.106129902408592 4359 5499307 SGTC_2203 7227154 166.4 µM -1.2484181548323 0.098074618572196 no 3041 0.105938981951889 4344 896304 SGTC_631 k072-0230 41.5 µM -1.25441551694821 0.0970169416123874 no 3042 0.104845507724715 4325 5773147 SGTC_2286 7945697 125 µM -1.25644648422926 0.0966606708962981 no 3043 0.104477068593219 4335 1245733 SGTC_1005 4092-0690 4.4 µM -1.25647228138204 0.0966561517684861 no 3044 0.10447239475555 4349 1529343 SGTC_1187 1391-0724 117 µM -1.25833771562064 0.0963297774733154 no 3045 0.10413482336125 4373 6997986 SGTC_3317 9138495 8.753 µM -1.26181680673415 0.095723244751903 no 3046 0.103507356552271 4245 17020139 SGTC_2603 homopterocarpin 100 µM -1.26421225705471 0.0953072665236249 no 3047 0.103076926309659 4312 101795 A weak amylase inhibitor. SGTC_16 erodoxin 22.806 µM -1.2673043210696 0.0947722886452165 no 3048 0.102523248029465 4355 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1398 3558-0053 112 µM -1.26785578988034 0.0946771084696163 no 3049 0.102424727282059 4292 4532369 SGTC_630 4356-0227 183 µM -1.26876059090447 0.0945210979519716 no 3050 0.102263232358139 4287 779312 SGTC_776 4476-4378 112 µM -1.26884320402237 0.0945068628148791 no 3051 0.102248496249975 4395 2892008 SGTC_2185 6113692 200 µM -1.27187192920711 0.093986071208649 no 3052 0.101709313478682 4338 874150 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.27431640644179 0.0935672882977991 no 3053 0.101275652180543 4298 6708739 YPR165W RHO1 SGTC_2321 7390090 138.78 µM -1.27563159793837 0.0933425432789945 no 3054 0.101042889425173 4362 649046 SGTC_1705 st027868 56.3335 µM -1.28095555558174 0.0924368389315858 no 3055 0.100104638705453 4286 292948 SGTC_2331 7980721 200 µM -1.28282756731458 0.0921199250212886 no 3056 0.0997762468759276 4308 2981221 SGTC_1325 1431-0015 227 µM -1.285291205679 0.0917040811492254 no 3057 0.0993452710832499 4362 1103340 SGTC_1035 k081-0041 55.2 µM -1.2878868736362 0.0912674579381396 no 3058 0.0988926727111713 4374 731709 SGTC_1218 1348-1416 30.7 µM -1.29071096957278 0.0907941631921184 no 3059 0.0984019597275304 4321 6787668 SGTC_2776 terbinafine 19.92 µM -1.29091465729064 0.0907600973910755 no 3060 0.0983666361508915 4365 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3070 9117005 49.47 µM -1.29706836422603 0.0897353861921737 no 3061 0.0973038327127243 4460 8779016 SGTC_408 cantharidin 100 µM -1.29720911221671 0.0897120499550525 no 3062 0.097279623142824 4334 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1408 3909-7976 48.8 µM -1.29890766961773 0.0894307821576507 no 3063 0.0969878086393945 4409 24152374 SGTC_1614 st002383 48.6 µM -1.30302626811046 0.0887514988039506 no 3064 0.0962828968722312 4400 1947235 SGTC_358 0075-0058 9.45 µM -1.30405664281883 0.0885821607927126 no 3065 0.0961071351645041 4331 1069125 SGTC_670 4204-0025 119 µM -1.30664416479722 0.0881579730493986 no 3066 0.095666794900024 4385 719039 SGTC_439 amiodarone 34.4 µM -1.31067854669101 0.0874996168115711 no 3067 0.0949831948250971 4244 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.31088779317521 0.087465570993019 no 3068 0.0949478377641563 4413 6708784 An antioxidant flavonoid SGTC_2269 7935389 174.42 µM -1.31453416035284 0.0868738687364573 no 3069 0.094333255082946 4351 97605 SGTC_910 3454-3003 490 µM -1.31736705654061 0.0864162379733917 no 3070 0.0938578089622271 4284 820824 SGTC_601 0986-0029 62.9 µM -1.31770772332952 0.0863613277324079 no 3071 0.0938007540643853 4329 24747981 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.32036156602863 0.085934462153887 no 3072 0.0933571646329095 4343 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1837 st055472 66.5 µM -1.32367795447519 0.0854032492024195 no 3073 0.0928050115462586 4440 676091 SGTC_17 0960-0276 49.807 µM -1.32723345969877 0.0848364711081712 no 3074 0.0922157336408511 4370 6821114 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.33015802172898 0.0843723885038532 no 3075 0.091733105931149 4378 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_952 1185-0122 232 µM -1.33175166813583 0.0841203047336254 no 3076 0.0914709023692299 4343 678600 SGTC_1462 k081-0014 26.5 µM -1.33318624127729 0.0838938671906329 no 3077 0.0912353466707215 3845 3270634 SGTC_2463 5473429 200 µM -1.33385683169747 0.0837881762194573 no 3078 0.0911253906817214 4376 5399405 SGTC_3052 9092717 49.47 µM -1.33546121863913 0.0835357166005525 no 3079 0.0908627199732521 4396 25237534 SGTC_1615 st002656 86.5 µM -1.33642922689233 0.0833836716060851 no 3080 0.0907045093361193 4404 1584458 SGTC_2326 6164455 177.58 µM -1.33792527338428 0.0831490969839684 no 3081 0.0904603987665304 4348 2888790 SGTC_2647 atorvastatin 60.16 µM -1.34098399127624 0.0826710461519196 no 3082 0.0899628251403738 4368 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_255 tunicamycin 200.472 nM -1.34328495294486 0.0823127914593716 no 3083 0.0895898612507573 4318 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_465 cgp-37157 41 µM -1.34487847060282 0.0820653702969747 no 3084 0.0893322419431779 4430 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_164 4100-3994 89.624 µM -1.34673138332027 0.0817783785862872 no 3085 0.0890333804436105 4390 4615967 SGTC_2862 9027634 71.43 µM -1.3482074276062 0.0815503006852122 no 3086 0.0887958381584893 4350 5012562 SGTC_897 1000-0139 31.4 µM -1.3507159277384 0.0811637887887511 no 3087 0.0883932240448042 4364 6151020 SGTC_3010 9080089 71.4286 µM -1.3508054153461 0.0811500260391612 no 3088 0.0883788864595971 4406 17027233 SGTC_1881 5652484 16 µM -1.35242507520328 0.0809012346733449 no 3089 0.0881196861618942 4385 2255129 SGTC_1054 3429-0080 167 µM -1.35278745908399 0.0808456488219999 no 3090 0.0880617701605408 4423 1162877 SGTC_1899 st063254 59.6 µM -1.35727036321229 0.080160401521381 no 3091 0.0873476602761568 4362 3093813 SGTC_2341 7987486 176.74 µM -1.35783130482629 0.0800749671398393 no 3092 0.0872586095495167 4429 1258686 SGTC_117 lucigenin 22.078 µM -1.35811929462387 0.0800311315185782 no 3093 0.0872129168714894 4390 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2945 9067681 61.76 µM -1.35838696089237 0.0799904056606008 no 3094 0.087170464761046 4459 16456930 SGTC_1002 4049-0206 172 µM -1.35887356570834 0.0799164080871394 no 3095 0.0870933283284055 4375 4662749 SGTC_1196 1588-0294 184 µM -1.36072098443116 0.079635944003132 no 3096 0.0868009402569676 4441 6144269 SGTC_2923 7992654 58.14 µM -1.36342229778544 0.0792271881293975 no 3097 0.0863747288386435 4398 2985126 SGTC_709 3807-1509 243 µM -1.36711682438075 0.078670716256407 no 3098 0.0857943452899868 4485 1886677 YPL242C IQG1 SGTC_1041 0206-0046 107 µM -1.36889854420831 0.0784034134977931 no 3099 0.0855154954463766 4407 50494 SGTC_227 fluconazole 33.516 µM -1.37204617816127 0.0779328729474386 no 3100 0.0850245313967249 4416 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3343 9148379 18.9835 µM -1.37229797440563 0.0778953246329463 no 3101 0.0849853479816683 4420 1955036 SGTC_2137 5261020 140 µM -1.37246035177981 0.0778711179054598 no 3102 0.0849600867145029 4394 763655 SGTC_1800 st050079 29.0735 µM -1.37400219569296 0.0776415488729712 no 3103 0.0847205003837544 4235 3645560 SGTC_1519 esterone 74 µM -1.37590039067156 0.0773596279398919 no 3104 0.0844262371341498 4393 698 A steroid. SGTC_768 0384-0033 77.3 µM -1.37743775084688 0.0771318688248987 no 3105 0.0841884740477927 4379 3965305 YMR134W ERG29 SGTC_1165 k072-0275 30.3 µM -1.37937724509836 0.0768452610953857 no 3106 0.0838892356671023 4392 6153523 YGL055W OLE1 SGTC_383 2324-0395 7.37 µM -1.38021573468129 0.0767216047174168 no 3107 0.0837601153740357 4409 3146421 SGTC_1506 4226-2149 212 µM -1.38173143001523 0.0764984613716479 no 3108 0.0835270900545462 4424 991114 SGTC_3231 9132313 49.47 µM -1.3844060475856 0.0761059042145038 no 3109 0.0831170791091085 4377 4905967 SGTC_357 1325-0123 420 µM -1.38726521059655 0.0756879589008722 no 3110 0.08268045363351 4443 1098503 SGTC_1978 st071761 42 µM -1.3876518923331 0.0756315692128894 no 3111 0.0826215358586724 4440 5147680 SGTC_1004 4084-0029 199 µM -1.39038920052269 0.0752333032199974 no 3112 0.0822053620336112 4431 716894 YLR208W SEC13 SGTC_427 1354-0053 47.3 µM -1.39219473430842 0.0749714826451115 no 3113 0.0819317184478326 4465 6813657 SGTC_2111 5486399 200 µM -1.39503838384104 0.074560534873636 no 3114 0.0815021325225578 4397 689674 SGTC_2954 9074818 52.69 µM -1.3952844043781 0.074525062378759 no 3115 0.0814650465489665 4452 16648742 SGTC_354 2783-3500 4.88 µM -1.3953728817943 0.0745123084039601 no 3116 0.0814517122739229 4427 6740761 SGTC_3256 9138902 49.47 µM -1.39591341701607 0.0744344267052167 no 3117 0.081370284910361 4532 17228773 SGTC_19 0279-0214 38.434 µM -1.39600478620807 0.0744212681407665 no 3118 0.0813565269318073 4497 3566274 YBR002C RER2 SGTC_951 1171-0579 82.7 µM -1.39863183614004 0.0740436918259444 no 3119 0.0809617071919101 4374 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_199 4063-0024 41.6 µM -1.39914922418485 0.073969502326729 no 3120 0.080884119618105 4465 306215 SGTC_271 rotenone 740 µM -1.40178363059127 0.0735926291380142 no 3121 0.0804899340432641 4463 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2292 7671323 168.05 µM -1.40262631886962 0.0734723861849182 no 3122 0.0803641496580266 4463 937504 SGTC_3349 9149703 23.001 µM -1.40872933555547 0.0726060283472566 no 3123 0.0794576085556479 4454 4910494 SGTC_2192 5915882 198.485 µM -1.41116339016147 0.0722626911823444 no 3124 0.0790982211088269 4411 2876149 SGTC_1591 genipin 88.4 µM -1.41119306525787 0.0722585130326325 no 3125 0.0790938471974501 4458 442424 A DNA cross-linking agent. SGTC_3331 9141060 1.957 µM -1.41346896686899 0.0719386253093575 no 3126 0.0787589398906375 4399 4906567 YPR165W RHO1 SGTC_1120 ficusin 1.78878 µM -1.41353631452816 0.0719291758760566 no 3127 0.0787490458288729 4454 6199 A DNA cross-linker. SGTC_2162 5663267 200 µM -1.41476190875949 0.071757381086891 no 3128 0.0785691579491203 4447 6456493 SGTC_2167 5876490 200 µM -1.41685898281056 0.0714641588737939 no 3129 0.0782620803796963 4481 686534 SGTC_47 0149-0135 24.25 µM -1.41738558838928 0.0713906711848927 no 3130 0.0781851119346618 4462 5239155 SGTC_35 0133-0054 64.071 µM -1.41921569511405 0.0711357311989782 no 3131 0.0779180707712893 4418 99677 SGTC_2694 st077685 81.9 µM -1.42407577126118 0.0704620996748833 no 3132 0.0772122696066932 4366 2838096 SGTC_805 3852-0218 479 µM -1.42416215289724 0.0704501712474961 no 3133 0.0771997689751596 4428 6615355 SGTC_3295 9122362 53.5725 µM -1.42467048243043 0.0703800075431803 no 3134 0.0771262377256316 4442 4730473 SGTC_751 0833-0568 350 µM -1.42603378090595 0.0701920994666231 no 3135 0.0769292956626336 4458 6954252 SGTC_2420 aureobasidin a 50 nM -1.42880896243005 0.0698107792614962 no 3136 0.0765295744435943 4517 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2391 6285546 200 µM -1.43502219667169 0.0689628403203905 no 3137 0.0756403862592213 4459 846083 SGTC_1253 0550-0034 176 µM -1.43840118039941 0.068505044712834 no 3138 0.0751601289572538 4463 5969915 SGTC_1710 st031758 61.5 µM -1.44026258700602 0.0682538587207393 no 3139 0.0748965610079642 4481 5394341 SGTC_3282 9108498 15.4605 µM -1.44242972327722 0.0679623124742515 no 3140 0.0745905918847112 4429 16459645 SGTC_3248 9135562 49.47 µM -1.44386234531214 0.0677701094781548 no 3141 0.0743888502270608 4465 17650701 SGTC_2628 lathosterol 100 µM -1.44522616571739 0.0675875273805485 no 3142 0.0741971845363885 4481 6710616 SGTC_900 1112-0045 141 µM -1.45930765228553 0.0657245168115322 no 3143 0.0722402250864805 4361 56211 YIL048W NEO1 SGTC_1612 st002233 45.4 µM -1.46109120665163 0.0654914170769938 no 3144 0.0719952065376731 4486 1035021 SGTC_3306 9127676 59.7925 µM -1.46433595511361 0.0650689929312476 no 3145 0.0715510888598742 4440 41905287 SGTC_2658 polymyxin b sulfate 77.05 µM -1.46831909802107 0.0645533341511312 no 3146 0.0710087828253709 4495 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1048 3161-0300 24.5 µM -1.47639903833501 0.0635170593613144 no 3147 0.0699184003643526 4482 2165101 SGTC_3321 9137793 26.8275 µM -1.47701775675463 0.0634382437293022 no 3148 0.0698354387590939 4448 4904192 SGTC_1507 4075-3230 155 µM -1.47712577906097 0.0634244910837736 no 3149 0.0698209622292072 4446 659771 SGTC_1283 0922-0125 16.4 µM -1.48342369511328 0.0626266888557921 no 3150 0.0689809378963226 4483 3360884 SGTC_849 0386-0493 241 µM -1.48896769866259 0.0619308832829961 no 3151 0.0682479374057274 4505 726119 SGTC_733 4069-0007 56.1 µM -1.48958794103435 0.0618534158808131 no 3152 0.0681663073439868 4487 5717425 YNL287W SEC21 SGTC_3066 9117245 49.47 µM -1.49511653152067 0.0611662403725331 no 3153 0.0674420160812218 4525 17176980 SGTC_3001 9076041 71.4286 µM -1.49771337486602 0.0608455322315568 no 3154 0.0671038676829098 4498 16004211 SGTC_1338 1486-1223 76 µM -1.49901780681292 0.06068493277826 no 3155 0.0669345063040441 4500 3444526 SGTC_608 k048-0125 159 µM -1.50363699402205 0.0601188909010701 no 3156 0.0663374301658945 4540 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3298 9116858 71.43 µM -1.50856096590467 0.0595200609901445 no 3157 0.0657055078577795 4552 2506942 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.51011338732875 0.059332235373017 no 3158 0.0655072470373394 4435 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1455 4262-0120 131 µM -1.5153291063624 0.0587045936170549 no 3159 0.0648445404245016 4543 1529587 SGTC_2467 5474540 200 µM -1.51567128412624 0.0586635999798694 no 3160 0.0648012461052393 4481 5413519 SGTC_1472 k841-0093 193 µM -1.51890483916251 0.0582773217486548 no 3161 0.0643932253905199 4581 X1472 SGTC_1460 k062-0059 9.15 µM -1.51891679890946 0.0582758967632525 no 3162 0.0643917199839339 4389 1373085 SGTC_1737 st035557 69.7 µM -1.51901293019325 0.0582644438632127 no 3163 0.0643796206653678 4348 5716916 SGTC_1966 st070145 16.1 µM -1.5233898646701 0.0577448546239038 no 3164 0.0638305981034024 4478 3748532 SGTC_2274 7947094 46.08 µM -1.53762358930298 0.0560803151370939 no 3165 0.0620703381457432 4464 2971028 SGTC_691 1548-0686 185 µM -1.54033380459005 0.0557677045778275 no 3166 0.0617395038862951 4492 46495133 SGTC_1335 1486-0900 202 µM -1.54331308676577 0.0554256467445762 no 3167 0.0613774149445136 4513 X1335 SGTC_2588 indole-3-carbinol 100 µM -1.54412700982356 0.0553324871552143 no 3168 0.061278783359104 4490 3712 Induces cell cycle arrest. SGTC_3097 9117246 49.47 µM -1.55110763872001 0.0545385713813816 no 3169 0.0604379454548768 4543 16423892 SGTC_467 ro 31-8220 72.8 µM -1.55251957650294 0.054379090585759 no 3170 0.0602689761278809 4501 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3041 9091929 49.47 µM -1.55392519549391 0.0542206901749413 no 3171 0.0601011304890403 4499 25236887 SGTC_198 3454-2873 16.191 µM -1.5646957925606 0.0530190288996862 no 3172 0.0588271277527615 4532 710957 SGTC_145 3737-0113 38.366 µM -1.56876811146911 0.0525702258808589 no 3173 0.0583509906518957 4514 6849351 SGTC_881 0833-0569 170 µM -1.58271040867193 0.0510564659556445 no 3174 0.0567437424041242 4556 5418700 SGTC_2032 5185112 25.99 µM -1.5839649927117 0.0509219706813892 no 3175 0.0566008428760243 4427 5718189 SGTC_2011 4012611 177 µM -1.59067003791119 0.0502079443061879 no 3176 0.0558419266456004 4512 2049887 SGTC_2024 5144227 134 µM -1.59119810042082 0.0501520511751662 no 3177 0.0557825001283849 4511 3475211 SGTC_1201 1889-3372 45.9 µM -1.59255338001904 0.0500088277031272 no 3178 0.0556302095408842 4451 5392199 SGTC_1730 st033808 45.1 µM -1.59677190941953 0.0495651079119019 no 3179 0.0551582798574762 4461 1045166 SGTC_675 1309-0189 238 µM -1.59794237911862 0.0494425522203507 no 3180 0.0550279006699835 4547 4246530 SGTC_1357 1503-1303 39.5 µM -1.59862395582005 0.049371298279587 no 3181 0.0549520917663509 4522 292895 SGTC_2418 pentamidine 31.67 µM -1.60686757170679 0.0485159640125239 no 3182 0.0540417107008865 4503 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1668 st014914 51.6 µM -1.60963997006735 0.0482309848765636 no 3183 0.0537382385222776 4578 2839556 SGTC_1247 0448-0043 5.84 µM -1.60969977603857 0.0482248521160622 no 3184 0.0537317069452049 4533 3089013 YGL099W LSG1 SGTC_855 0428-0020 25 µM -1.61346703054695 0.0478397974399877 no 3185 0.0533215402517683 4569 6812414 SGTC_788 1182-0090 188 µM -1.61522175556436 0.0476612875584611 no 3186 0.0531313404321856 4548 5715185 SGTC_14 0354-0009 295 µM -1.62795153661457 0.046382195286541 no 3187 0.0517675811605072 4654 1713507 SGTC_3334 9142812 21.919 µM -1.63312583534484 0.0458702216658982 no 3188 0.0512212669912856 4555 45283678 SGTC_1479 0549-0158 134 µM -1.63726059698062 0.0454643782554286 no 3189 0.0507880151440134 4608 5440202 SGTC_2486 5283202 22.39 µM -1.63938376328396 0.045257105863756 no 3190 0.0505666804977042 4565 1377751 SGTC_2508 celastrol 40.54 µM -1.64040010614023 0.0451581556224888 no 3191 0.0504610016465772 4498 122724 Celastrol is a natural product and antioxidant. SGTC_3352 9151559 45.5865 µM -1.64851866786833 0.0443739748186166 no 3192 0.049623141581494 4569 17159339 SGTC_1401 3807-4679 7.6 µM -1.65712132316479 0.0435550477844375 no 3193 0.0487474744532496 4502 3291456 SGTC_2873 9040596 71.43 µM -1.66116587049644 0.0431742664574492 no 3194 0.0483400690203984 4533 6463863 SGTC_2028 5153890 36.43 µM -1.66127604452439 0.0431639316608791 no 3195 0.0483290094614106 4559 2830968 YPR165W RHO1 SGTC_2091 4-phenylthiadiazole 200 µM -1.66725025141582 0.0426065106026314 no 3196 0.0477323271584051 4589 270010 SGTC_2309 7664088 163.95 µM -1.66776834519531 0.0425584455940367 no 3197 0.0476808610179729 4545 704922 SGTC_1366 1683-0113 21.9 µM -1.66983466118515 0.0423671836714584 no 3198 0.0474760402812767 4583 708623 SGTC_442 cape 100 µM -1.67456413323419 0.0419320318023778 no 3199 0.0470098906934222 4610 5281787 SGTC_443 clozapine 122 µM -1.68245002360668 0.0412145149823594 no 3200 0.0462408040891391 4581 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_411 enrofloxacin 100 µM -1.68904552619962 0.0406220799461534 no 3201 0.0456053528908052 4619 71188 A bacterial gyrase inhibitor. SGTC_2900 5328528 85.29 µM -1.70577903080071 0.0391499805808899 no 3202 0.0440246143542313 4580 795359 SGTC_75 0159-0059 199.013 µM -1.71045272779594 0.0387466696727239 no 3203 0.04359109390441 4611 5377270 SGTC_1342 1486-1464 234 µM -1.72332833966947 0.0376530651361294 no 3204 0.0424145828352089 4614 3253938 SGTC_918 glabranin 770.725 nM -1.73828243642147 0.0364146886219118 no 3205 0.0410805297928554 4603 124049 Also referred to as licorice root. SGTC_291 SEC14.278 35.5 µM -1.74567388371309 0.0358150121794183 no 3206 0.0404338178456631 4620 1068044 SGTC_3002 9075603 71.4286 µM -1.75177725844425 0.0353259594822065 no 3207 0.039906058058587 4557 20105405 SGTC_487 nimodipine 119 µM -1.75224293133473 0.0352888719181989 no 3208 0.0398660222112949 4624 4497 L-type voltage-gated calcium channels inhibitor SGTC_722 3534-0461 190 µM -1.75689693879897 0.034919964818753 no 3209 0.0394676887639945 4615 658262 SGTC_361 000s-0510 1.45 µM -1.75753747883316 0.0348694401448999 no 3210 0.0394131197088232 4513 660 SGTC_2053 5265679 138 µM -1.75826760780613 0.0348119220587955 no 3211 0.0393509932459647 4525 764595 SGTC_2366 9070441 60.58 µM -1.76611997413734 0.0341982387229247 no 3212 0.0386878615505864 4582 6837235 SGTC_50 0929-0078 56.389 µM -1.76612500169151 0.0341978486737189 no 3213 0.0386874399088272 4475 1377751 SGTC_1750 st081859 2.357 µM -1.76731720397481 0.0341054580846675 no 3214 0.0385875601152394 4533 5291695 SGTC_3228 9131799 49.47 µM -1.76796695637677 0.0340551915126134 no 3215 0.0385332139740041 4645 17015818 SGTC_863 0466-0191 129 µM -1.77020232512183 0.0338827225644168 no 3216 0.0383467210761452 4654 765160 YPR165W RHO1 SGTC_2555 cholic acid 100 µM -1.77024291424353 0.0338795975813575 no 3217 0.0383433416108585 4584 6708657 Influences liver metabolism. SGTC_1836 st055642 81 µM -1.77143060565017 0.0337882613578096 no 3218 0.0382445614400198 4586 8571 SGTC_1082 camptothecin 424.86 nM -1.77260847849466 0.033697880382156 no 3219 0.0381468029178599 4498 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_43 0570-0105 72.5 µM -1.77267930969021 0.0336924516841277 no 3220 0.0381409307269748 4571 1114046 YDL195W SEC31 SGTC_2539 epi(13)torulosol 80 µM -1.77965941041051 0.0331609968887765 no 3221 0.0375658584863109 4581 6708597 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.78187445475442 0.032993797147621 no 3222 0.0373848535725662 4677 688664 SGTC_2936 9038235 15.59 µM -1.78742485834089 0.0325778818386503 no 3223 0.0369344234313656 4551 4749415 SGTC_3056 9094900 49.47 µM -1.7935968483802 0.0321204761408844 no 3224 0.0364387699730811 4611 25236784 SGTC_1745 st081495 74 µM -1.79518066540643 0.0320039582843121 no 3225 0.0363124599677062 4486 13842402 YBL026W LSM2 SGTC_72 0744-0168 198.391 µM -1.7978247838179 0.0318102142953614 no 3226 0.0361023892802886 4522 677577 SGTC_612 0302-0167 22.4 µM -1.80170388354343 0.0315277331209774 no 3227 0.0357960033803027 4619 235821 SGTC_2199 6590217 200 µM -1.80412055984444 0.031352798145257 no 3228 0.0356062046454106 4614 703109 SGTC_1306 1185-0270 9.02 µM -1.81617939985417 0.03049185352391 no 3229 0.0346714285160983 4640 1548076 SGTC_2820 7989630 71.43 µM -1.8318444553964 0.0294027775804168 no 3230 0.0334872989355777 4656 2984098 SGTC_773 4358-1457 44.6 µM -1.83556464786537 0.0291489413351951 no 3231 0.0332110348271667 4631 1186886 SGTC_950 1165-0508 94.1 µM -1.84969474414603 0.0282013492900695 no 3232 0.0321787792326533 4627 6148369 SGTC_1764 st044502 93.5 µM -1.8517916170427 0.0280629384449803 no 3233 0.032027875942672 4644 8407 SGTC_481 bay k-8644 50 µM -1.86022492956729 0.0275119705293763 no 3234 0.0314268547027941 4617 2303 A calcium channel antagonist. SGTC_1186 1319-0216 26 µM -1.86940428260485 0.0269225424965468 no 3235 0.0307832946058747 4677 4565136 SGTC_860 0443-0016 25.1 µM -1.88256184536029 0.0260960792172358 no 3236 0.0298798855946748 4646 5337942 SGTC_3220 9131269 49.47 µM -1.88903084674282 0.0256975884072641 no 3237 0.0294438477565135 4656 17722206 SGTC_731 3966-0296 387 µM -1.88949162383337 0.0256693998967933 no 3238 0.0294129920449391 4669 660956 SGTC_820 1582-0060 59.9 µM -1.90570580623252 0.0246938378238788 no 3239 0.0283441927854275 4680 3848840 SGTC_1061 3448-9325 110 µM -1.90737820570592 0.0245950076483528 no 3240 0.0282358147711403 4636 723482 SGTC_402 epigallocatechin gallate 10 µM -1.90866696777593 0.024519075093144 no 3241 0.0281525334777564 4632 65064 An antioxidant. SGTC_493 zm226600 134 µM -1.91712107436387 0.0240258314134733 no 3242 0.0276112759394301 4664 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3098 9119039 49.47 µM -1.93256084791738 0.0231465294971068 no 3243 0.0266451597277139 4661 17161528 SGTC_3290 9121031 71.43 µM -1.94376953521543 0.0225253002947179 no 3244 0.0259616245310699 4676 17014854 SGTC_3114 9122766 49.47 µM -1.95673133405862 0.0218244940476777 no 3245 0.0251895319451163 4672 17176985 SGTC_2502 avocadyne acetate 18.59 µM -1.96126955874355 0.021583518388808 no 3246 0.024923793189768 4647 3952079 SGTC_1597 7-benzyloxygramine 47.5 µM -1.96260010890717 0.0215132950728533 no 3247 0.0248463290339794 4572 260807 SGTC_3152 9099253 49.47 µM -1.97904185853336 0.0206613578656573 no 3248 0.0239056468258641 4530 25236131 SGTC_345 1362-0200 395 µM -1.98517730677885 0.0203508524061559 no 3249 0.0235623740898942 4669 1419823 SGTC_835 0312-0010 67.2 µM -1.98890444781897 0.0201641656870144 no 3250 0.0233558753746364 4707 1626196 SGTC_2135 5326629 150.42 µM -2.01342828065556 0.0189716695542763 no 3251 0.0220347964602245 4660 5020077 SGTC_607 4491-0986 66.8 µM -2.03140421834939 0.0181361464534645 no 3252 0.0211070034337201 4683 698981 YDR232W HEM1 SGTC_726 3448-4391 34.2 µM -2.04778805905662 0.0174021475226329 no 3253 0.0202903854432364 4726 1356692 SGTC_2407 paclitaxel 400 µM -2.04910334599717 0.0173443383231004 no 3254 0.0202260051921695 4690 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2951 9072950 58.06 µM -2.05055740717409 0.0172806207188495 no 3255 0.0201550339188101 4641 16488155 SGTC_2315 7733312 200 µM -2.05242019301368 0.0171992848778006 no 3256 0.0200644218701485 4628 726316 SGTC_3236 9132701 49.47 µM -2.05890122421139 0.0169188439822285 no 3257 0.0197518508993344 4715 24282524 SGTC_2109 5483026 200 µM -2.06028161949824 0.0168596205815376 no 3258 0.0196858130211969 4704 759335 SGTC_671 0560-0003 407 µM -2.07132715252621 0.0163920851542992 no 3259 0.0191641167456699 4697 3238678 SGTC_1860 st056228 74.6 µM -2.07343393143955 0.0163041815668699 no 3260 0.0190659569224534 4685 688679 SGTC_1318 1280-3875 124 µM -2.07390195316 0.0162847086519675 no 3261 0.0190442088129249 4708 373245 SGTC_828 2074-0507 139 µM -2.08585584386151 0.0157940538829181 no 3262 0.0184958415563449 4726 X828 SGTC_1098 clofazimine 15.1 µM -2.09113664272741 0.0155813709781924 no 3263 0.0182579084045179 4726 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_991 3996-0057 64.7 µM -2.10265614917276 0.0151259395636768 no 3264 0.0177479189279857 4705 715343 SGTC_1189 1431-2119 7.28 µM -2.11301072424212 0.0147263731414241 no 3265 0.0172999249967618 4711 3107275 SGTC_561 1550-0330 72.9 µM -2.12376740570946 0.0143209387068525 no 3266 0.0168447988903232 4702 6812934 SGTC_3003 9075612 71.4286 µM -2.13019209634785 0.0140833978449815 no 3267 0.0165778786586644 4713 6501993 SGTC_2895 9054447 58.44 µM -2.13033555376888 0.014078132766327 no 3268 0.0165719601307125 4745 2697450 SGTC_2444 5485484 36.41 µM -2.14072263727203 0.0137013938018315 no 3269 0.0161482059366165 4727 6790631 SGTC_655 k060-0012 42 µM -2.143454509188 0.0136037655697936 no 3270 0.0160383100764474 4727 5994525 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.14412163619123 0.0135800160205327 no 3271 0.016011570938827 4661 676296 Flavone; oxidizing agent. SGTC_1350 1495-0454 146 µM -2.14888192908706 0.0134115871760849 no 3272 0.0158218803244593 4724 1069057 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.15061410108667 0.0133507485829678 no 3273 0.0157533356957946 4733 688788 SGTC_3007 9078383 71.4286 µM -2.1604041099731 0.0130113583134968 no 3274 0.0153706997824681 4726 6496995 SGTC_2254 7938975 95.19 µM -2.16258076192481 0.0129369220279686 no 3275 0.0152867196216996 4716 2969277 SGTC_480 am 92016 50 µM -2.16664566178392 0.0127988977560407 no 3276 0.0151309414198551 4723 2129 K+ channel blocker. SGTC_2443 5493264 126.67 µM -2.16978426252024 0.0126931993783508 no 3277 0.0150115965605899 4728 5340055 SGTC_2937 9044753 11.33 µM -2.16981446905185 0.0126921857965591 no 3278 0.01501045190362 4666 6465530 YGL099W LSG1 SGTC_3225 9130819 49.47 µM -2.18933276475731 0.0120517193609415 no 3279 0.0142863312919417 4700 4547121 SGTC_3356 9151811 4.48 µM -2.18965810962476 0.0120412854950514 no 3280 0.0142745206368355 4742 1859254 YPR165W RHO1 SGTC_1091 telmisartan 47.6 µM -2.19200916231051 0.0119661193719512 no 3281 0.0141894225299222 4743 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1034 k072-0165 12.7 µM -2.1971069170218 0.0118045342885002 no 3282 0.0140064056162187 4729 5835461 SGTC_2136 5328288 199.296 µM -2.19891966011832 0.0117475333057187 no 3283 0.0139418177035461 4688 262395 SGTC_666 0272-0154 136 µM -2.20451111743671 0.0115732143704029 no 3284 0.0137442094831847 4718 6870312 SGTC_404 fumagillin 50 µM -2.2405117454745 0.0105037413394687 no 3285 0.0125288595598921 4728 12015870 A methionine aminopeptidase binder. SGTC_2368 9071271 200 µM -2.25569762927128 0.0100790975172468 no 3286 0.0120447870763687 4730 27209959 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.25731098659355 0.0100348757512511 no 3287 0.0119943246692882 4721 3256 An antibiotic and ribosome inhibitor. SGTC_1980 st071811 45.7 µM -2.28523069613184 0.00929598619620417 no 3288 0.0111496520958209 4765 4974850 SGTC_2237 6667747 47.222 µM -2.28776064111419 0.00923144564085207 no 3289 0.0110757320380807 4720 729940 YDL015C TSC13 SGTC_2830 7992007 71.43 µM -2.31653195481794 0.00852461121122549 no 3290 0.0102646208922627 4681 1952075 SGTC_2040 5100729 123 µM -2.3254129351946 0.00831624104412109 no 3291 0.0100249452374739 4759 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_452 diindolylmethane 8 µM -2.35322029765604 0.00769245637306997 no 3292 0.00930580201333459 4738 3071 Inhibits expression of several cancer promoting factors. SGTC_1596 piperlongumine 63 µM -2.37062798013957 0.00732326335410234 no 3293 0.00887894744444304 4754 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2251 lansoprazole 556 µM -2.40238358884561 0.00668984109438464 no 3294 0.00814430901289976 4739 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2427 5545055 42.75 µM -2.4105715356743 0.00653458212683149 no 3295 0.00796377374033377 4731 5372858 SGTC_976 1348-1067 47.6 µM -2.41223397496767 0.0065034511846678 no 3296 0.00792755155978054 4766 5310671 YGL099W LSG1 SGTC_1868 st057644 42.7 µM -2.41717352803579 0.00641172539787383 no 3297 0.00782077916596744 4762 688665 SGTC_68 0986-0284 82.829 µM -2.42316586572757 0.00630198789270522 no 3298 0.007692949974146 4693 423278 YIL048W NEO1 SGTC_3350 9150499 3.57 µM -2.43264057042752 0.00613186911651805 no 3299 0.00749458599533181 4749 4910996 YPR165W RHO1 SGTC_1931 st074438 57.1 µM -2.43278091030206 0.00612938018606963 no 3300 0.00749168199894263 4750 2787313 SGTC_3174 9107204 49.47 µM -2.43515305135246 0.00608744543441792 no 3301 0.00744274600429564 4746 3938802 SGTC_1709 st033179 39.1045 µM -2.43531242449872 0.00608463716895349 no 3302 0.00743946834180655 4759 573381 SGTC_1937 st074714 47.2 µM -2.44438343238521 0.00592667992072192 no 3303 0.00725499810166258 4728 17250970 SGTC_2268 7933382 153.85 µM -2.48280794205871 0.0052971777516652 no 3304 0.0065175673185065 4749 935025 YOR257W CDC31 SGTC_3165 9101544 49.47 µM -2.4929433952931 0.00514136968286472 no 3305 0.00633445205943798 4760 5002184 SGTC_190 3970-0790 3.722 µM -2.50496575690879 0.00496185358811548 no 3306 0.00612316245436215 4758 2832352 SGTC_1514 1189-1591 158 µM -2.5111948777578 0.0048710553408747 no 3307 0.00601616264346857 4754 767698 YMR146C TIF34 SGTC_1297 1068-0111 14.1 µM -2.51912521807122 0.00475760372539489 no 3308 0.00588234050167371 4771 767057 SGTC_2643 anethole 100 µM -2.53499850788831 0.00453757458619128 no 3309 0.00562239025068049 4773 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_665 3914-0008 307 µM -2.53514355852847 0.00453560655419781 no 3310 0.00562006261779138 4753 1069549 SGTC_937 3122-0005 46.7 µM -2.53635396512245 0.00451921357400828 no 3311 0.00560067251991621 4751 759535 SGTC_2129 girgensonine 121.053 µM -2.53896778488542 0.00448399400267767 no 3312 0.00555900301358765 4742 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_930 2810-3379 265 µM -2.58277983624085 0.00392905040337456 no 3313 0.0049003922079303 4757 1015764 SGTC_602 3130-1533 38.1 µM -2.59179567232736 0.00382279405312502 no 3314 0.00477382294829992 4776 720941 SGTC_2261 9010538 184.68 µM -2.60335782380964 0.0036903008163295 no 3315 0.00461577740528129 4756 6457250 SGTC_449 xestospongin c 11.1929 µM -2.61833388687991 0.00352481573599095 no 3316 0.00441801502875356 4775 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_767 0929-0023 86 µM -2.62213639382678 0.00348387321280498 no 3317 0.00436902264971032 4779 1204563 SGTC_2312 7706453 155.7 µM -2.62299277180806 0.00347471152143042 no 3318 0.0043580560858296 4754 976098 SGTC_3158 9100007 49.47 µM -2.6324886227334 0.0033745639957721 no 3319 0.00423809309277872 4770 19297233 SGTC_2532 xanthone 78.9 µM -2.71099251066795 0.00264100839262472 no 3320 0.00335410707073405 4778 7020 An insecticide. SGTC_1520 flindersine 88 µM -2.719844065449 0.00256806151134502 no 3321 0.0032656353962972 4772 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1987 st072290 61.9 µM -2.72048649499608 0.00256283871245534 no 3322 0.00325929672509209 4783 54697379 SGTC_2361 9034121 116 µM -2.7830629054392 0.00209782605458971 no 3323 0.00269241822882363 4784 6496917 SGTC_3348 9149464 3.537 µM -2.79076762024026 0.00204620775587011 no 3324 0.00262916048226298 4773 1951442 SGTC_2629 bisabolol 100 µM -2.88380228202166 0.00150774178804162 no 3325 0.00196452677896075 4780 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1097 itavastatin 7.23 µM -3.05832243021159 0.000831147987155921 yes 3326 0.00111289973692082 4801 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1886 st057356 49.9 µM -3.06573167502543 0.000809863307128696 yes 3327 0.00108569041618101 4797 24207747 SGTC_1464 k208-0027 110 µM -3.08406239278181 0.000759342076960917 yes 3328 0.00102097383477191 4775 X1464 SGTC_787 4152-0075 138 µM -3.13043303045525 0.000644219808694825 yes 3329 0.000872743964739733 4788 9566539 SGTC_2436 5633522 8.09 µM -3.17853689427554 0.00054199413115765 yes 3330 0.00074010189406417 4790 5724242 SGTC_3159 9100096 49.47 µM -3.18174297316879 0.000535745121516341 yes 3331 0.000731958359464629 4774 25236875 SGTC_2810 7959871 45.46 µM -3.22408697903731 0.000459229402771389 yes 3332 0.00063187504427964 4778 2974535 SGTC_2240 6690706 185.951 µM -3.31305696384152 0.0003303012530133 yes 3333 0.00046141091268563 4773 805876 SGTC_839 0122-0028 230 µM -3.3411481737366 0.000297179498118923 yes 3334 0.000417163417760682 4802 759448 SGTC_45 0kpi-0036 14.9 µM -3.38923337868997 0.000247559610936689 yes 3335 0.000350441656026733 4760 2795021 SGTC_2360 9040895 200 µM -3.42023595255899 0.000219786494655689 yes 3336 0.000312834210641023 4798 4914414 SGTC_2933 9026794 32.47 µM -3.48405953972439 0.000171519489978091 yes 3337 0.000246934804676397 4789 17586027 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -3.57015590437509 0.000121975271540638 yes 3338 0.000178384413140669 4786 5355888 SGTC_2822 7994718 71.43 µM -3.61778720367009 0.000100692999523073 yes 3339 0.000148566265890772 4799 1018011 SGTC_2833 9001315 45.46 µM -3.70134993602654 7.15393749249462e-05 yes 3340 0.000107227737143066 4786 2989378 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.70683123906357 6.99361860020206e-05 yes 3341 0.000104934345055451 4794 6708760 SGTC_2949 9072542 2.23 µM -3.76750314768953 5.43102217895284e-05 yes 3342 8.24442311970158e-05 4791 16457352 SGTC_2125 5246583 200 µM -3.8122398778075 4.49661157521003e-05 yes 3343 6.88565638738148e-05 4802 835267 SGTC_2365 9042475 200 µM -4.08393522997923 1.3685802945912e-05 yes 3344 2.2139688775953e-05 4806 6464479 SGTC_2310 7668677 200 µM -4.2198483561673 7.34170166044983e-06 yes 3345 1.22233351122014e-05 4793 2197143 SGTC_2116 5511452 16.8835 µM -4.30976228609961 4.81324294172853e-06 yes 3346 8.17150616580277e-06 4809 870744 SGTC_2112 5488546 200 µM -4.39422671616439 3.21348377455777e-06 yes 3347 5.55838762025758e-06 4809 600757 SGTC_2249 haloperidol 116.36 µM -4.9078706368842 2.35867791700287e-07 yes 3348 4.60352742688577e-07 4803 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2257 7960413 200 µM -5.4159957941444 1.36871508140957e-08 yes 3349 3.0474266807008e-08 4809 2974689 YIL048W NEO1 SGTC_2570 licareol 100 µM -5.44097081670581 1.18196384456463e-08 yes 3350 2.64954976842432e-08 4808 443158 SGTC_2423 st077119 87.2 µM -5.85803156010967 9.28739414774422e-10 yes 3351 2.34192827056051e-09 4770 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2241 6772625 37.8075 µM -7.4441014863569 1.14771512590694e-14 yes 3352 4.88032227493387e-14 4794 2285411