SGTCid condition conc unit YIL168W|YIL168W.score YIL168W|YIL168W.strain.pval YIL168W|YIL168W.strain.significant YIL168W|YIL168W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2772 vinpocetine 57.06 µM 9.79822217707408 2.80727152578867e-23 yes 1 5.72922846699774e-23 1 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_429 1112-0049 25.5 µM 5.25863015188481 6.0333420335752e-08 yes 2 7.25662246261485e-08 17 2836170 SGTC_2763 lisinopril 49.32 µM 5.11100740438049 1.34743153998367e-07 yes 3 1.60222711584045e-07 2 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_265 mycophenolic acid 32.932 µM 4.82449780858715 6.02783991664351e-07 yes 4 7.01782302748205e-07 4 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_676 falcarinol 140 µM 4.69116630535841 1.17763658068593e-06 yes 5 1.35826022487169e-06 39 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3004 9076122 71.4286 µM 4.49239122090632 3.09436815876777e-06 yes 6 3.52139469227813e-06 10 44782551 SGTC_2597 laccaic acid a 100 µM 4.40911322850594 4.58522279676608e-06 yes 7 5.18973750339065e-06 24 5491415 A textile dye. SGTC_748 act1.228 77.9 µM 4.29051792888421 7.9342018461868e-06 yes 8 8.91284465893279e-06 70 4421505 YNR035C ARC35 SGTC_1511 0906-3109 28.5 µM 4.26707389560543 8.82824638171551e-06 yes 9 9.90267855040701e-06 36 2882180 SGTC_2769 toremifene 3.73 µM 4.11496632853525 1.74217147916886e-05 yes 10 1.93617969117054e-05 18 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2328 6201408 200 µM 4.10058816566263 1.85562873583505e-05 yes 11 2.06050695250776e-05 17 2890418 SGTC_1224 0823-0416 294 µM 4.01488785324974 2.69153422842405e-05 yes 12 2.97370335809632e-05 5 3598164 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 3.96991606439007 3.26222987907725e-05 yes 13 3.59489776234787e-05 14 7104 SGTC_138 0850-0259 40.9225 µM 3.96573851490536 3.32069689802094e-05 yes 14 3.65845213358511e-05 199 6813004 SGTC_544 k015-0020 52.4 µM 3.91336466448736 4.14309463721299e-05 yes 15 4.55094609343746e-05 12 3008304 SGTC_2256 7954252 200 µM 3.84815458976217 5.43701519642726e-05 yes 16 5.95054741195416e-05 9 2972920 SGTC_2848 9016370 25.97 µM 3.74339853970314 8.34142942735178e-05 yes 17 9.07739645950987e-05 30 7894410 SGTC_399 oxolinic acid 75 µM 3.67573282391154 0.000109360924265931 yes 18 0.000118583816135959 11 4628 A DNA gyrase inhibitor. SGTC_3000 9075062 71.4286 µM 3.59317496543295 0.000151278233324782 yes 19 0.000163336537258248 34 17057871 SGTC_1416 3966-0321 25.3 µM 3.58875293855268 0.000153901851937617 yes 20 0.000166131764891449 28 582530 YLR208W SEC13 SGTC_2299 7976368 114.88 µM 3.58232679162959 0.000157790560039265 yes 21 0.000170273704604893 44 2979718 SGTC_2771 fluoxetine 41.05 µM 3.56671917361603 0.000167621688597986 yes 22 0.000180739246451986 30 3386 A selective serotonin reuptake inhibitor. SGTC_2049 5262831 67.185 µM 3.55312053997116 0.000176651684109879 yes 23 0.000190344991023485 42 763417 SGTC_745 0469-0705 296 µM 3.48545076417463 0.000228753149349487 yes 24 0.000245654314866436 37 3486736 SGTC_2029 5175081 200 µM 3.47848415619036 0.000234863116851012 yes 25 0.000252129123103331 37 1380876 SGTC_1451 4152-0210 104 µM 3.33604778067181 0.000398515173778276 yes 26 0.000424892785954929 48 659563 SGTC_2005 4024620 188 µM 3.30641460427202 0.000443771580843079 yes 27 0.000472490748051771 47 236743 SGTC_1525 8-methoxypsoralen 92.5 µM 3.24917747832647 0.000544953589998032 yes 28 0.000578696210891049 61 4114 Related to psoralen; DNA damaging agent. SGTC_371 0195-0006 7.36 µM 3.23759631597369 0.000567862190500628 yes 29 0.0006027062131739 43 3928593 SGTC_2020 4017018 200 µM 3.18814686412295 0.000676048597923982 yes 30 0.00071593895013683 52 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_741 4582-0002 126 µM 3.10236770619243 0.000909827443283519 yes 31 0.000959896669908644 52 2912688 SGTC_235 0330-0087 5 mM 3.08959001688987 0.000950413221870275 yes 32 0.00100216479336083 63 46494818 YHR062C RPP1 SGTC_2446 5162541 200 µM 3.05491400467787 0.00106907806099682 no 33 0.00112562531239048 31 1549321 SGTC_744 1594-0068 283 µM 3.02778545264428 0.00117122375894137 no 34 0.00123176461116022 69 668392 SGTC_2929 9013348 24.6 µM 2.99695969314855 0.00129808828832525 no 35 0.00136343382552843 64 2995952 SGTC_1751 st044839 27.194 µM 2.99531182194497 0.00130521149984211 no 36 0.00137082204807625 33 5291326 SGTC_2198 6589944 200 µM 2.97070247428983 0.00141592865886942 no 37 0.00148559737897069 37 5290268 SGTC_1336 1486-0901 104 µM 2.96976669279483 0.00142030320078808 no 38 0.00149012998481321 55 5006114 SGTC_2044 5102272 200 µM 2.96783699747412 0.00142936302336199 no 39 0.00149951662935749 41 592666 SGTC_1461 k072-0203 53.8 µM 2.95178519993328 0.00150679499947052 no 40 0.00157971314179939 57 5418714 SGTC_1170 0310-0127 64.8 µM 2.94744412947453 0.00152838326598206 no 41 0.00160206323350195 81 774975 SGTC_1373 2887-0003 58.5 µM 2.94484122429202 0.0015414624851598 no 42 0.00161560215723795 68 776948 SGTC_2592 piperlongumine 83.33 µM 2.92031901101733 0.00166978743426908 no 43 0.00174836620223746 83 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_634 1611-4317 11.2 µM 2.91450782208735 0.00170158976010086 no 44 0.00178124940517 60 2843522 SGTC_630 4356-0227 183 µM 2.91438610843398 0.00170226170713724 no 45 0.00178194411022634 40 779312 SGTC_1518 st038567 90.8 µM 2.89205901344052 0.00182968972464391 no 46 0.00191363025244183 59 77966 SGTC_641 4092-0595 30 µM 2.86806677521232 0.00197623876209528 no 47 0.00206494179825219 58 786260 SGTC_670 4204-0025 119 µM 2.86379291064213 0.00200343601231403 no 48 0.00209300793559999 82 719039 SGTC_673 1082-0474 110 µM 2.85326688926288 0.00207187459464848 no 49 0.00216361312704916 142 3098046 SGTC_1309 pyrazolanthrone 13.4 µM 2.84987185177973 0.00209439689563575 no 50 0.00218684234858182 66 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2712 st079126 47.7 µM 2.84761097192681 0.00210951827940758 no 51 0.00220243669591863 62 3152970 SGTC_549 1661-1316 519 µM 2.82786029082885 0.00224588740243554 no 52 0.00234301260120502 70 2857282 SGTC_2451 5856223 45.7 µM 2.79455553894297 0.00249402958811258 no 53 0.00259855564200732 74 2179896 SGTC_1568 digitonin 820 nM 2.79062988582983 0.00252485548272233 no 54 0.00263027943028271 94 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1126 isoteolin 1.0172 µM 2.77609095997768 0.00264204424418537 no 55 0.00275084070669883 101 133323 SGTC_1378 2093-0007 380 nM 2.76868982508705 0.00270356764132322 no 56 0.00281410943058845 93 3618014 SGTC_1328 1441-0025 69.2 µM 2.7450450222383 0.00290888305914563 no 57 0.00302512983500452 54 4562601 SGTC_1766 st045414 44.774 µM 2.70578142286852 0.0032810399743929 no 58 0.00340719409625054 118 253960 SGTC_2788 5282734 71.43 µM 2.69026634067283 0.00343953302763969 no 59 0.00356975063754807 137 743706 SGTC_2035 5154463 94.595 µM 2.68060202435743 0.00354170193081325 no 60 0.00367449292377477 98 2769623 SGTC_2656 pseudo-anisatin 100 µM 2.66784037119405 0.00368078744413559 no 61 0.00381702596032086 24 6708809 A neurotoxin. SGTC_2416 tofa 880 nM 2.66238231128331 0.00374175477456202 no 62 0.00387948484463522 127 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_210 3551-0445 56.827 µM 2.65688075482204 0.003804122895554 no 63 0.00394336670877111 130 2865180 YOR207C RET1 SGTC_1320 1313-0481 95.3 µM 2.63727088967262 0.00403408007385908 no 64 0.00417880304681827 83 6813365 YLR208W SEC13 SGTC_1169 aniline yellow 25.8 µM 2.58865729771015 0.00465868990184073 no 65 0.00481754652612933 69 6051 A DNA damaging agent. SGTC_2028 5153890 36.43 µM 2.58116749743245 0.00476223766987073 no 66 0.00492333971147003 104 2830968 YPR165W RHO1 SGTC_1915 st067105 30.6 µM 2.55896917314135 0.00508129276107826 no 67 0.00524915251890505 157 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.48912505043851 0.00621283100171342 no 68 0.00640289573844195 102 689007 SGTC_2555 cholic acid 100 µM 2.47708368708176 0.00642901567334179 no 69 0.00662304196026506 88 6708657 Influences liver metabolism. SGTC_2905 7799065 20.05 µM 2.46567097628716 0.00664003049305562 no 70 0.00683784450806588 88 1296806 SGTC_3196 9111891 49.47 µM 2.45635450108453 0.00681680234574433 no 71 0.00701773126827014 87 18891510 SGTC_690 glyoxal 20.3 µM 2.4403453542673 0.00713028616949631 no 72 0.007336613428212 210 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3217 9129673 49.47 µM 2.42702329731654 0.00740077795950574 no 73 0.0076116391230157 161 17248312 SGTC_2936 9038235 15.59 µM 2.42592115135711 0.00742355582807873 no 74 0.00763479369875116 142 4749415 SGTC_3002 9075603 71.4286 µM 2.41515346335642 0.00764936001111648 no 75 0.00786429061413643 133 20105405 SGTC_2463 5473429 200 µM 2.38647777288854 0.008280451863546 no 76 0.0085053178088369 114 5399405 SGTC_3066 9117245 49.47 µM 2.34841955414495 0.00918839629434621 no 77 0.00942663565465362 131 17176980 SGTC_1819 st053448 58.6 µM 2.34328740798841 0.00931727044974569 no 78 0.00955732607671902 135 2857616 SGTC_2882 9058044 58.44 µM 2.34169128916674 0.00935767195469424 no 79 0.00959829295911741 121 18076804 SGTC_191 3914-0123 66.505 µM 2.33834140619356 0.00944296399031516 no 80 0.00968477233847757 49 3144412 SGTC_2069 5228469 200 µM 2.33384947582341 0.00955840055399572 no 81 0.0098018025447007 126 2835210 SGTC_2369 9071472 200 µM 2.32359765734281 0.00982648915198782 no 82 0.0100735340571467 152 17296037 SGTC_725 1497-0963 19 µM 2.31288821433983 0.0101135354277048 no 83 0.0103643929864285 121 3549977 SGTC_885 0865-0106 16.8 µM 2.30875466683899 0.0102262687784945 no 84 0.0104785994583724 176 2793380 SGTC_3200 9114385 49.47 µM 2.30093959134075 0.0104424053169711 no 85 0.010697522924723 159 17018030 YLR208W SEC13 SGTC_2111 5486399 200 µM 2.29292958472478 0.0106680538577697 no 86 0.0109260296204502 200 689674 SGTC_1909 st060837 51.5 µM 2.28275496701495 0.0109607955467422 no 87 0.011222402985891 191 678937 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.2800689768486 0.0110392327527798 no 88 0.0113017989195802 163 688761 SGTC_222 nsc-310342 10.666 µM 2.25996136008272 0.0116420856920325 no 89 0.0119118245421974 71 432556 SGTC_1825 st052143 62.6 µM 2.25467569089372 0.0118052244277721 no 90 0.012076846292015 121 674173 SGTC_3134 9127454 49.47 µM 2.25020975465302 0.0119446050443877 no 91 0.0122178166861949 118 24262820 SGTC_1904 st060225 78 µM 2.24895179506616 0.0119841223487183 no 92 0.0122577815720542 129 66595 SGTC_3295 9122362 53.5725 µM 2.23190895576693 0.0125307794518196 no 93 0.0128104904326005 140 4730473 SGTC_2713 st079149 53.4 µM 2.21615035064006 0.0130553226613685 no 94 0.0133406034384583 183 3103253 SGTC_1107 amlodipine 47 µM 2.21508510347115 0.0130914556806561 no 95 0.0133771118552154 190 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_732 3970-1727 52.7 µM 2.21340581686454 0.0131485923506606 no 96 0.0134348399975323 126 1275699 SGTC_3027 9089541 49.47 µM 2.2105754498883 0.0132453815379265 no 97 0.0135326251882039 178 9943819 SGTC_1100 amiodarone 5.07 µM 2.20792682167625 0.0133365127472922 no 98 0.0136246873885939 167 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1952 st077036 64.1 µM 2.20428741892575 0.0134626164434937 no 99 0.0137520685873032 184 2937007 SGTC_2655 perillic acid 100 µM 2.20384236423537 0.0134781078086325 no 100 0.013767716032381 91 5702197 An apoptosis inducer. SGTC_2913 7966556 36.57 µM 2.19754199810926 0.0136990659851573 no 101 0.0139908802295649 131 2976516 SGTC_1594 piperine 70.1 µM 2.19575710502594 0.0137622287291275 no 102 0.0140546667024095 174 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1834 st055981 52.8 µM 2.18948945209365 0.0139860185827572 no 103 0.0142806421848994 180 471719 YDL150W RPC53 SGTC_3115 9123671 49.47 µM 2.18424876832708 0.0141755412413223 no 104 0.0144719865572575 108 3286988 SGTC_3189 9110682 49.47 µM 2.17496656562541 0.0145166531044249 no 105 0.014816310978617 178 17122418 SGTC_1826 st055655 41.6 µM 2.17206091055794 0.0146248748526789 no 106 0.0149255344448503 197 676168 SGTC_1323 1348-1351 11.2 µM 2.1686526536074 0.0147527001703295 no 107 0.0150545322336737 136 6989654 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.16296960110906 0.0149679780942713 no 108 0.0152717588867779 233 2724 A muscle relaxant with antifungal properties. SGTC_1799 st045822 46.1415 µM 2.16257590472829 0.014982991092515 no 109 0.0152869065837477 145 3674992 SGTC_1880 MG-132 525 µM 2.16173670612635 0.0150150358305558 no 110 0.0153192383111693 148 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3223 9129970 49.47 µM 2.16151823167669 0.0150233879193244 no 111 0.0153276650840871 177 17248386 SGTC_2912 7964298 10.93 µM 2.15411111925419 0.0153089276173158 no 112 0.0156157293768232 282 2975850 SGTC_2317 5986382 200 µM 2.14009910579381 0.015861844084804 no 113 0.0161733791740982 138 877883 SGTC_2679 rapamycin 1 nM 2.13494394230003 0.0160695332368437 no 114 0.0163827946910073 352 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_324 1315-0088 19.6 µM 2.12243072629349 0.0165833769661808 no 115 0.0169007921138862 136 6787421 SGTC_1965 Pectolinarigenin 58.4 µM 2.1119033615398 0.0170265031728425 no 116 0.0173473695053609 162 5320438 An anti-inflammatory. SGTC_162 k030-0015 37.8 µM 2.09144010123294 0.0179168662008783 no 117 0.0182443152974138 164 1809920 YMR134W ERG29 SGTC_2520 obtusaquinone 4.71 µM 2.07516391109343 0.0186531198053392 no 118 0.0189856730469232 177 5967872 SGTC_1680 diphenhydramine 100 µM 2.07321730514598 0.0187428750740321 no 119 0.0190760302957256 211 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_110 0850-0284 111.64 µM 2.0665307018818 0.0190539897168805 no 120 0.0193891982623075 115 3906265 SGTC_3182 9108849 49.47 µM 2.05996754066093 0.0193636205117082 no 121 0.0197008220038591 213 17133045 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.04685072522506 0.0199952573306661 no 122 0.0203363717067538 239 5379071 SGTC_1554 st069299 38.7 µM 2.04503462585923 0.0200840737888551 no 123 0.0204257222626684 212 24207999 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.02879988359729 0.0208930031719322 no 124 0.0212393385848357 233 688667 SGTC_1893 st059353 36.1 µM 2.02604252201719 0.0210330984382497 no 125 0.0213802136785551 211 3112488 SGTC_460 trequinsin 123 µM 2.02496816481439 0.0210878988734221 no 126 0.0214353166409535 135 5537 A vasodilator. SGTC_2648 atorvastatin 78.68 µM 2.02381904849577 0.0211466462516467 no 127 0.0214943867724426 175 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_408 cantharidin 100 µM 2.0172373706155 0.0214858015123272 no 128 0.021835373957658 231 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_819 1013-0258 27.7 µM 2.01435969088553 0.0216355272625246 no 129 0.0219858915943478 248 5753198 SGTC_2284 7945075 39.21 µM 2.00532147093469 0.022111530959465 no 130 0.0224643454437581 244 1245402 SGTC_3074 9116018 49.47 µM 2.00474842148752 0.0221420066556001 no 131 0.0224949745563509 177 17027303 SGTC_2441 5730946 39.09 µM 1.99957748453539 0.0224186119993156 no 132 0.0227729536069472 233 1774275 SGTC_3323 9138564 53.9225 µM 1.99560647484541 0.0226330037749935 no 133 0.0229883870998379 241 43912313 YNL103W MET4 SGTC_1233 0325-0408 14.2 µM 1.99235023130873 0.0228100931443121 no 134 0.0231663219487411 222 12874 SGTC_545 4218-0007 221 µM 1.98354138457294 0.0232950189771264 no 135 0.0236534945849948 228 2840508 SGTC_3038 9091290 49.47 µM 1.97557555966997 0.0237409794356312 no 136 0.0241014344950828 220 25236843 SGTC_1455 4262-0120 131 µM 1.95614435302716 0.0248590118894953 no 137 0.0252240757938388 253 1529587 SGTC_433 pimozide 108 µM 1.95416993341582 0.0249750478540377 no 138 0.0253405618952162 167 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2041 5107442 45.335 µM 1.95410533345401 0.0249788520307991 no 139 0.0253443807414414 263 793005 SGTC_1261 0712-0010 12.7 µM 1.94928287287851 0.0252642131225185 no 140 0.025630826393576 265 2840123 SGTC_1322 1348-1070 12 µM 1.94735830982803 0.025378856025618 no 141 0.0257458962704867 167 6758089 SGTC_94 0334-0113 514.748 µM 1.94298093407135 0.0256412322349382 no 142 0.0260092309955133 244 6795178 SGTC_627 1391-0720 175 µM 1.94145929971596 0.0257329679782831 no 143 0.0261012957804205 220 997839 SGTC_1418 3966-3099 2.4 µM 1.94087199302461 0.0257684487115336 no 144 0.026136902936429 254 740335 SGTC_3035 9091303 49.47 µM 1.94052007697519 0.0257897284907959 no 145 0.0261582583139427 159 25237002 SGTC_2277 7947813 106.88 µM 1.9402823161093 0.0258041138185897 no 146 0.026172694651578 256 1246798 SGTC_300 r073-0011 5.04 µM 1.93386601193368 0.026194864764603 no 147 0.0265648019750975 267 2735780 SGTC_2418 pentamidine 31.67 µM 1.93109385322669 0.0263652124763656 no 148 0.0267357235132085 262 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1206 3978-0017 132 µM 1.93046380487726 0.0264040574828356 no 149 0.0267746978979999 236 3873677 SGTC_2790 5423970 71.43 µM 1.92373402190861 0.0268219675846053 no 150 0.0271939656116206 309 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3001 9076041 71.4286 µM 1.91250827061952 0.0275313551328047 no 151 0.0279055164083428 220 16004211 SGTC_355 1311-2252 105 µM 1.9082178199202 0.0278065810267597 no 152 0.0281815346843931 273 5338538 SGTC_1752 st044819 83.042 µM 1.87668176513168 0.0299007017957595 no 153 0.0302808616590297 264 441209 YML126C ERG13 SGTC_2654 protoveratrine a 100 µM 1.87113261244065 0.0302823933007082 no 154 0.0306633511353127 233 5702278 A heart drug and vasodilator. SGTC_3234 9132280 49.47 µM 1.86668998263203 0.0305908767346757 no 155 0.0309724467238647 269 17612295 SGTC_585 0kpi-0023 191 µM 1.861260850873 0.0309713891361604 no 156 0.0313536744228253 235 64601 SGTC_441 propafenone 146 µM 1.85844600866283 0.0311702101680833 no 157 0.031552851920301 197 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1694 st024011 44.9 µM 1.84410751926033 0.0321994349468362 no 158 0.0325837361594933 290 2787533 SGTC_2952 9073731 13.78 µM 1.83932929548956 0.0325485885383881 no 159 0.0329333833281876 312 16457353 SGTC_2387 9077560 195.08 µM 1.83914043826332 0.0325624525869873 no 160 0.0329472662624571 272 5303272 SGTC_1468 k284-1086 134 µM 1.82735534012665 0.0334372829131937 no 161 0.0338231797780772 347 15996457 SGTC_379 3970-0972 5.9 µM 1.82423938683707 0.0336717933246492 no 162 0.0340579447327999 297 2898042 YBL034C STU1 SGTC_2010 4012422 159 µM 1.82238406280384 0.0338120689958022 no 163 0.0341983655312911 286 952393 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.8222422509018 0.0338228107317755 no 164 0.0342091181614855 307 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2889 9059656 51.95 µM 1.82169816588606 0.0338640492448392 no 165 0.0342503982096871 269 3949838 SGTC_2683 piperine 63.03 µM 1.81988502540014 0.0340017735375797 no 166 0.0343882579043204 227 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2371 9071574 200 µM 1.81253529520619 0.0345647773964204 no 167 0.0349517627036669 232 45596039 SGTC_359 0081-0058 15.9 µM 1.81113996590609 0.0346725225415667 no 168 0.0350595941769751 297 3494159 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.80574300346345 0.0350918672304758 no 169 0.0354792460459593 323 6708561 SGTC_1879 gemcitabine 100 µM 1.80299116608794 0.0353072820826653 no 170 0.035694801023743 264 60750 A nucleoside analog which inhibits DNA replication. SGTC_1629 st005085 44.9 µM 1.79848746712972 0.0356621725492746 no 171 0.036049896481275 302 24207091 SGTC_1652 st011932 78 µM 1.79514273703888 0.0359276241574547 no 172 0.0363154805753461 261 1551076 SGTC_1833 st055984 71 µM 1.79429335447309 0.0359952917681764 no 173 0.0363831791275366 264 676288 SGTC_2837 9008476 45.46 µM 1.7914811994004 0.0362200725299166 no 174 0.0366080544667551 327 2992805 SGTC_482 fipronil 114 µM 1.78865272499459 0.0364473156616973 no 175 0.0368353804650491 179 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1330 1469-0054 61.8 µM 1.77439659970641 0.0376104941515421 no 176 0.0379987859566823 267 7102664 SGTC_2911 7942208 15.64 µM 1.77306882650664 0.0377203549176943 no 177 0.0381086513904814 256 1243384 SGTC_2079 5212404 121 µM 1.76779791235041 0.0381590602499999 no 178 0.0385473470308475 264 758462 SGTC_787 4152-0075 138 µM 1.76327296244592 0.0385389894385994 no 179 0.0389272315721445 307 9566539 SGTC_3102 9121669 49.47 µM 1.76112673877197 0.0387202680463449 no 180 0.0391084771436192 237 41905072 SGTC_2696 st077691 74.316 µM 1.75613617615171 0.0391444772137486 no 181 0.0395325796850156 287 757133 SGTC_2436 5633522 8.09 µM 1.75505759913155 0.0392366540755776 no 182 0.0396247279844106 322 5724242 SGTC_2188 6126565 140.678 µM 1.75220764913323 0.039481065500351 no 183 0.0398690544262566 227 874518 SGTC_2094 5332512 191.667 µM 1.7513056049154 0.0395586822509935 no 184 0.0399466413913607 318 755774 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.75054335941428 0.0396243666695832 no 185 0.0400122995540463 287 2346 DNA damaging agent; causes G2/M arrest. SGTC_2760 etidronate 98.04 µM 1.75009403483133 0.0396631275180595 no 186 0.0400510444582168 331 3305 A chelator and antioxidant. SGTC_420 mitomycin C 81.9 mM 1.74745922649014 0.0398910393734587 no 187 0.0402788558215529 322 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2300 7976697 71.57 µM 1.74533853142711 0.0400752524367574 no 188 0.0404629792800245 264 2236109 SGTC_2026 5148700 152 µM 1.73470899076659 0.0410090225428467 no 189 0.0413961815072736 300 79838 SGTC_282 k297-0036 65.7 µM 1.72410844713271 0.0419577422081212 no 190 0.0423441337220179 249 5061378 SGTC_2112 5488546 200 µM 1.72286293058117 0.0420703697272847 no 191 0.0424566576348991 336 600757 SGTC_911 3456-4043 236 µM 1.71143471741705 0.0431152435771297 no 192 0.043500446430316 358 914281 SGTC_2095 5432005 200 µM 1.70882264864099 0.0433569826472473 no 193 0.043741903037974 278 783734 SGTC_999 SEC7.066 22.7 µM 1.70312250249907 0.0438883140465942 no 194 0.0442725728108748 362 740511 YDR170C SEC7 SGTC_3272 9137413 49.47 µM 1.69203203835197 0.0449371415789485 no 195 0.0453199325563894 300 17614870 SGTC_850 0388-0143 75.9 µM 1.69046125423867 0.0450873088789597 no 196 0.0454698724129807 308 67273 SGTC_2782 7736369 71.43 µM 1.68974313448494 0.0451560956673144 no 197 0.0455385535874214 371 2950836 YOL077C BRX1 SGTC_2461 5755302 26.15 µM 1.68531797743682 0.0455818351534356 no 198 0.045963619537556 353 2788904 SGTC_1690 st023502 41.2 µM 1.68487920835359 0.0456242239216499 no 199 0.0460059393821783 295 24207482 SGTC_1282 0886-0010 32.4 µM 1.68134480874575 0.0459668334417031 no 200 0.0463479795314995 360 2836211 YNL267W PIK1 SGTC_228 caffeine 993.056 µM 1.68014247029289 0.0460838530592951 no 201 0.0464647996889062 270 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.67954490337831 0.0461421012203873 no 202 0.0465229476232977 196 1241132 A phosphatase inhibitor. SGTC_2355 9061122 103.12 µM 1.67655429906766 0.046434501045193 no 203 0.0468148348938412 302 5302957 SGTC_303 1348-1668 34.2 µM 1.6729832207635 0.0467856018786466 no 204 0.0471652996335269 299 5380509 SGTC_1364 1653-0028 37.6 µM 1.67254312163176 0.0468290185027265 no 205 0.0472086360439402 345 5718652 SGTC_3023 9089636 49.47 µM 1.67063833060265 0.047017302558069 no 206 0.0473965682977393 309 17249241 SGTC_1138 3761-0006 1.03 µM 1.66719283718359 0.0473594230879451 no 207 0.047738033281634 276 12061087 SGTC_2557 derrustone 83.84 µM 1.66566868920014 0.0475113985251662 no 208 0.0478897108076872 405 629853 An antioxidant. SGTC_288 1315-0019 35.1 µM 1.66317027609854 0.0477613644952941 no 209 0.0481391778646028 347 6811474 SGTC_2447 5741742 33.78 µM 1.66281143219758 0.0477973531200461 no 210 0.0481750937491258 374 1776504 SGTC_2569 tetrandrine 100 µM 1.66098645122144 0.0479807174598315 no 211 0.0483580839321998 296 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1208 2323-2347 50.3 µM 1.65212211743314 0.048879381543094 no 212 0.0492548295177226 322 5412760 SGTC_182 3448-4371 550.524 µM 1.64902051572729 0.0491969791982865 no 213 0.0495717158888033 374 3491403 SGTC_1117 retinoic acid 1.10837 µM 1.64832122579693 0.0492688122316535 no 214 0.0496433856642438 376 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3082 9117008 49.47 µM 1.64647246067887 0.049459126036939 no 215 0.049833262707661 336 41448529 SGTC_2165 5727197 32.143 µM 1.64196754981951 0.0499253236414694 no 216 0.0502983646336286 357 1361712 SGTC_3077 9117319 49.47 µM 1.63600617775298 0.0505476252319992 no 217 0.0509191472335375 278 17154678 SGTC_2487 5918373 44.05 µM 1.63509414894722 0.0506433736597033 no 218 0.0510146562762664 345 2876279 SGTC_2824 7998404 51.95 µM 1.63118529831783 0.0510553777861401 no 219 0.0514256132420059 337 837851 SGTC_2646 retinol 96.75 µM 1.63076705804219 0.0510996190524655 no 220 0.05146974042211 338 445354 A vitamin A analog and teratogen. SGTC_1876 myriocin 605 nM 1.63012502026138 0.0511675928751753 no 221 0.051537538341198 336 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2092 5303694 80.6725 µM 1.62851940453599 0.0513378975887981 no 222 0.0517073990600132 383 1963699 SGTC_44 0929-0055 61.211 µM 1.62516338241096 0.0516953207604751 no 223 0.0520638752466645 325 1379590 SGTC_666 0272-0154 136 µM 1.62506688556688 0.0517056270533876 no 224 0.0520741539300044 400 6870312 SGTC_1560 lithocholic acid 53.1 µM 1.6209082997852 0.0521513365844037 no 225 0.0525186532923543 243 9903 A bile acid which acts as a detergent. SGTC_1847 st056231 15 µM 1.61614773998133 0.0526653049901326 no 226 0.0530311873008161 444 5393180 SGTC_1900 st060200 72.8 µM 1.61168961577808 0.0531502581068546 no 227 0.0535147492439 357 688945 SGTC_555 4296-0685 37 µM 1.61135709459618 0.053186571058588 no 228 0.0535509565626943 375 2908540 YHR072W ERG7 SGTC_327 1273-0057 3.96 µM 1.60879326200528 0.0534672150676119 no 229 0.0538307773594733 352 3108138 SGTC_1881 5652484 16 µM 1.60794775494675 0.0535600234029953 no 230 0.0539233108079629 383 2255129 SGTC_237 nikkomycin 200 µM 1.60779187580596 0.0535771476335021 no 231 0.053940384174985 373 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3171 9103192 49.47 µM 1.60589043324433 0.0537863814858814 no 232 0.0541489929435945 304 13018434 SGTC_514 4466-0038 2.65 nM 1.59960323599583 0.0544828318913087 no 233 0.0548433150649474 503 5722064 SGTC_1484 3473-2379 286 µM 1.59671021359612 0.0548056870066863 no 234 0.055165158949672 431 671917 SGTC_3033 9090887 49.47 µM 1.5958604760934 0.0549008026736899 no 235 0.0552599737523776 408 19325384 SGTC_2640 pentamidine 10.38 µM 1.59543933397832 0.0549479916924282 no 236 0.0553070130094871 412 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_587 k089-0003 57 µM 1.59328933789349 0.0551893986840565 no 237 0.0555476487274055 228 9659696 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.58752854677964 0.0558403656206598 no 238 0.0561964934100443 447 65057 A dermal irritant. YDR527W RBA50 SGTC_106 0092-0003 11.579 µM 1.58310172485322 0.0563446988333371 no 239 0.0566991402770863 284 1072148 SGTC_2190 6049624 200 µM 1.58264577568186 0.0563968469196597 no 240 0.056751111915891 303 2265554 SGTC_728 3030-5151 22.5 µM 1.5810881420179 0.0565752845186563 no 241 0.0569289428245503 336 3125388 SGTC_606 k015-0008 38.6 µM 1.56545534003637 0.0583908592321613 no 242 0.0587380906144713 414 1970475 SGTC_3103 9120822 49.47 µM 1.56413210628418 0.0585466148779894 no 243 0.0588932737139031 400 17141819 SGTC_281 1672-3440 14.9 µM 1.56300680100912 0.0586793291948706 no 244 0.0590254975822368 404 6833000 SGTC_2170 morpholine 200 µM 1.56128312973777 0.0588830703160954 no 245 0.0592284811347882 334 121171 Reacts with secondary amines. SGTC_3008 9078912 71.4286 µM 1.55878013443588 0.0591799167577341 no 246 0.0595242138061423 362 16648731 SGTC_605 1315-0399 119 µM 1.55533425573873 0.0595905043993273 no 247 0.0599332414867731 424 24020461 SGTC_3031 9088762 49.47 µM 1.55317525721661 0.0598488914727101 no 248 0.0601906353783755 407 205253 SGTC_2990 9074105 71.4286 µM 1.54835264821319 0.0604292263764146 no 249 0.0607687075685093 355 6502001 SGTC_3148 9097893 49.47 µM 1.54671307491767 0.0606275264897465 no 250 0.060966224428063 394 17174100 SGTC_1683 st010134 710 nM 1.53955322083895 0.0614994540547615 no 251 0.0618346477907351 409 3818134 SGTC_619 1652-1634 108 µM 1.53716879071774 0.0617919941295167 no 252 0.0621259904012518 359 5400454 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.53673493655994 0.0618453392832373 no 253 0.0621791160265553 239 6708630 An antioxidant. SGTC_1314 1222-0010 41.1 µM 1.5300973471179 0.062665962791386 no 254 0.0629963174103076 370 3526027 SGTC_2470 5664817 21.68 µM 1.51739145325881 0.0642604727199694 no 255 0.0645839402507625 364 2859561 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.51141334283721 0.0650215137993928 no 256 0.0653415859758054 489 688664 SGTC_705 1124-0212 310 µM 1.51102849525864 0.0650707453287948 no 257 0.0653905954925097 432 9554485 SGTC_734 2023-0417 80 µM 1.5109382965546 0.06508228815898 no 258 0.0654020862281617 428 3935732 SGTC_2211 7117706 200 µM 1.50371987741774 0.0660111999167354 no 259 0.066326754448106 383 822771 SGTC_2915 7971052 15.16 µM 1.50035447933344 0.0664477766637712 no 260 0.0667613021626333 285 5741558 SGTC_271 rotenone 740 µM 1.50025311686512 0.0664609605196264 no 261 0.066774424404092 456 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2958 9077254 16.72 µM 1.49824024261885 0.0667231875346767 no 262 0.0670354217731316 386 16457351 SGTC_548 1436-0017 110 µM 1.49149510811675 0.0676077486104984 no 263 0.0679157772996549 520 9677137 SGTC_1478 0453-0656 35.7 µM 1.4901816188627 0.0677810496247798 no 264 0.0680882440505732 429 5258496 SGTC_344 k064-0035 6.43 µM 1.48934463157619 0.0678916601021163 no 265 0.0681983202996166 416 5088750 SGTC_754 3474-0146 171 µM 1.48844688244839 0.0680104553307052 no 266 0.0683165402506971 398 24762078 SGTC_1460 k062-0059 9.15 µM 1.48655007923444 0.0682619787340231 no 267 0.0685668404544541 405 1373085 SGTC_3268 9137683 49.47 µM 1.48330448413011 0.0686940214473183 no 268 0.0689967657589984 358 1953228 SGTC_1168 k815-0004 80.5 µM 1.48185349569068 0.0688878529313759 no 269 0.0691896406270886 429 642433 SGTC_2206 7254556 146.969 µM 1.47886595484374 0.0692882734984787 no 270 0.0695880720201911 347 4398905 SGTC_273 hydroxyurea 18.1 mM 1.47670912779589 0.0695784661100309 no 271 0.0698768121702754 502 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2403 6032726 181.2 µM 1.47593072220606 0.0696834270314407 no 272 0.0699812455076644 429 2881040 SGTC_2525 harmine 47.85 µM 1.4718954213825 0.0702295055430624 no 273 0.0705245601055582 361 5280953 A monoamine oxidase inhibitor SGTC_2159 5658611 73.75 µM 1.47166726213943 0.0702604793009068 no 274 0.0705553761392834 398 793844 SGTC_703 3875-0075 71.8 µM 1.47151009299247 0.0702818219085845 no 275 0.0705766100070805 421 2850814 SGTC_2880 9042983 58.44 µM 1.47016119180997 0.0704651994923518 no 276 0.0707590512952549 443 6464714 SGTC_591 4299-0174 154 µM 1.4675423657071 0.0708222681613257 no 277 0.0711142866239542 406 5509088 SGTC_2155 5570423 76 µM 1.46182998186415 0.0716059551626682 no 278 0.0718939029674093 422 797402 SGTC_777 1315-0167 517 µM 1.45983819838766 0.0718807685666845 no 279 0.07216727380982 424 4221767 SGTC_889 0919-1524 82.7 µM 1.45814184130859 0.0721154580889523 no 280 0.0724007252286854 428 3905452 SGTC_2053 5265679 138 µM 1.44758631489778 0.0735890251087718 no 281 0.0738663903719245 472 764595 SGTC_980 1473-0395 201 µM 1.44473121053701 0.0739915308941172 no 282 0.0742666998443748 392 768876 SGTC_430 0958-0115 16.4 µM 1.44446764019964 0.0740287730543509 no 283 0.0743037379767772 453 6833180 SGTC_1385 3091-4834 14.1 µM 1.44444855805491 0.0740314698934722 no 284 0.0743064200361802 416 4072814 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.43820135387135 0.0749184150616125 no 285 0.0751884656019182 438 5282362 SGTC_2955 9076254 12.21 µM 1.43720987364089 0.0750599224283248 no 286 0.0753291841529177 418 16459619 SGTC_588 3970-1144 52.9 µM 1.43659985311692 0.0751470878248487 no 287 0.0754158626894156 486 1888707 SGTC_3005 9076496 71.4286 µM 1.43295671271789 0.0756692612419102 no 288 0.0759351041553822 418 21368410 SGTC_1124 fisetin 1.16336 µM 1.43211531234398 0.0757902516433149 no 289 0.0760554114670535 424 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1817 st052116 64.4 µM 1.43173584887255 0.0758448653366525 no 290 0.0761097163624018 440 4361398 SGTC_2657 nystatin 74.44 µM 1.42716859558776 0.0765045535328843 no 291 0.0767656520960992 479 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2072 5231554 129 µM 1.42638453161753 0.0766182403840889 no 292 0.07687868810421 453 789545 SGTC_1437 4092-1038 11.6 µM 1.41965686175566 0.0775990187398382 no 293 0.0778538013164524 476 3977136 SGTC_2067 5224629 34.075 µM 1.4176401299556 0.077894872716607 no 294 0.0781479288380946 482 2835000 SGTC_1508 1080-0625 72.9 µM 1.41522285039717 0.0782506138856549 no 295 0.0785015834152533 425 767111 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.413342691111 0.0785281600861917 no 296 0.0787774936331206 451 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3332 9141069 11.198 µM 1.40686782999275 0.0794896802930783 no 297 0.0797332922201654 413 17332883 SGTC_3186 9110464 49.47 µM 1.40618943865802 0.0795909351655019 no 298 0.0798339397286236 470 17018021 SGTC_1635 st007035 42.4 µM 1.40149079917198 0.0802949219292326 no 299 0.0805336785091961 687 3716403 SGTC_1347 1493-0251 600 nM 1.400115221959 0.0805019094891539 no 300 0.0807394087332858 521 3986378 SGTC_3286 9117135 37.221 µM 1.39673917632358 0.0810116223565007 no 301 0.0812460093617839 477 3438150 SGTC_331 k048-0133 24.5 µM 1.39642852739312 0.0810586460082184 no 302 0.0812927447509915 429 6813582 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.39036705703125 0.0819803121676037 no 303 0.0822087223307687 525 1377 SGTC_2954 9074818 52.69 µM 1.38894293237523 0.0821979960874623 no 304 0.0824250520389857 477 16648742 SGTC_2893 9048488 25.97 µM 1.38707544840732 0.0824841089055128 no 305 0.082709378809552 455 6467338 SGTC_169 k015-0017 16.025 µM 1.38698781553639 0.0824975533246343 no 306 0.082722739131417 444 1840002 SGTC_1555 citronellol 128 µM 1.38552391562543 0.0827223852642844 no 307 0.0829461624389245 448 8842 A terpine precursor. SGTC_1558 st069300 45.6 µM 1.38155551957526 0.0833341872690526 no 308 0.0835541097787123 398 24208000 SGTC_849 0386-0493 241 µM 1.38141809208989 0.0833554350425718 no 309 0.0835752231166175 463 726119 SGTC_867 0518-0118 155 µM 1.38067795699517 0.0834699379529797 no 310 0.0836890009133017 496 6848158 SGTC_1209 2323-2347 50.3 µM 1.38001034372637 0.0835733227115706 no 311 0.0837917300274266 453 5412760 SGTC_1731 st035964 63 µM 1.3774846520121 0.0839653150572883 no 312 0.0841812283759304 495 6739575 SGTC_2853 9015042 58.44 µM 1.37235469290215 0.0847657421967895 no 313 0.0849765235689003 459 6457456 SGTC_648 0375-0473 33.3 µM 1.37094056947076 0.0849873905805947 no 314 0.0851967415905593 545 1713139 SGTC_3137 9097352 49.47 µM 1.36953813673611 0.0852076353532437 no 315 0.085415561108604 543 44120435 SGTC_809 3998-0021 90 µM 1.36461332528678 0.0859844395316975 no 316 0.086187307190291 462 715485 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.36433524483738 0.0860284594713213 no 317 0.08623103904995 485 6710655 SGTC_2316 5844804 197.44 µM 1.36271688352658 0.0862849796003519 no 318 0.0864858773627084 618 776813 SGTC_880 0833-0487 87.2 µM 1.36148663562781 0.0864803637882794 no 319 0.0866799770522678 496 76075 SGTC_2424 5537928 59.2 µM 1.36072480707086 0.0866015207815949 no 320 0.0868003360151067 557 5382802 SGTC_1274 0865-0114 173 µM 1.36015375162976 0.0866924214383631 no 321 0.0868906371710641 499 870624 SGTC_260 nsc-65238 3.989 µM 1.35820638119227 0.0870029402535756 no 322 0.0871991031696994 489 3246252 SGTC_973 1325-0077 65.9 µM 1.35746987048758 0.0871205971653515 no 323 0.0873159802828897 542 2835149 SGTC_1531 st059297 52.4 µM 1.35385221337363 0.087700240268664 no 324 0.0878917658905928 513 7566702 SGTC_2678 equilin 100 µM 1.35306539473479 0.087826689223185 no 325 0.0880173698649832 510 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_377 3970-0964 33.1 µM 1.35287770796606 0.0878568722825033 no 326 0.0880473510466833 608 16481235 SGTC_1521 st012942 49.4 µM 1.34964402196495 0.0883781167252588 no 327 0.0885650980987026 558 24207259 SGTC_914 3820-6779 408 µM 1.34869672784428 0.0885312485488882 no 328 0.0887171984902691 489 2893481 SGTC_1655 st012546 55.1 µM 1.33701102548483 0.0904365507548107 no 329 0.0906095189719311 476 720985 YLR208W SEC13 SGTC_1384 3089-0840 101 µM 1.33093722789355 0.0914388022083802 no 330 0.091604833206443 474 1069836 SGTC_1190 1486-1332 13 µM 1.33039838338602 0.0915281142241756 no 331 0.0916935234702334 507 4150046 SGTC_1943 st076331 65.2 µM 1.32976079658066 0.0916338759941039 no 332 0.0917985482221588 542 24208415 SGTC_508 roscovitine 141 µM 1.32812524054501 0.0919055931682064 no 333 0.0920683681728798 516 160355 A CDKinase inhibitor. SGTC_3179 9107801 49.47 µM 1.32571538899997 0.0923070317790749 no 334 0.0924669940457432 516 4818259 SGTC_227 fluconazole 33.516 µM 1.32541014296626 0.0923579728225062 no 335 0.0925175773347907 584 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_554 4483-2211 187 µM 1.32345279261667 0.0926851201214011 no 336 0.0928424226792667 521 747107 SGTC_1615 st002656 86.5 µM 1.32322473279818 0.0927232932239124 no 337 0.0928803266806656 513 1584458 SGTC_1844 rapamycin 4 nM 1.32317198890619 0.0927321232559039 no 338 0.0928890944505921 666 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3091 9116372 49.47 µM 1.31962188713582 0.0933278882305207 no 339 0.0934806457897187 485 17169793 SGTC_2818 7996756 12.99 µM 1.31783467304221 0.0936288798558997 no 340 0.0937794990668284 420 2241621 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.31550215377425 0.0940227858302525 no 341 0.0941705969897956 513 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_760 0568-0725 82.9 µM 1.3143032354536 0.094225729257196 no 342 0.0943720894559994 542 3916171 SGTC_553 k007-0256 45.7 µM 1.31419229496048 0.0942445247081581 no 343 0.0943907503822513 550 6287000 SGTC_3192 9110362 49.47 µM 1.31383189846216 0.0943056018826018 no 344 0.0944513902393731 544 16649480 SGTC_598 3937-0236 20.2 µM 1.31150483450828 0.0947006773957326 no 345 0.0948436307331057 599 1379313 SGTC_2219 9098279 200 µM 1.31070250136324 0.0948371752988785 no 346 0.0949791466344431 502 902349 SGTC_1060 3448-7350 82 µM 1.30965535305655 0.0950155406754101 no 347 0.0951562268701426 583 570178 SGTC_223 busulfan 5 mM 1.30827958628423 0.0952502565124712 no 348 0.0953892482275351 433 2478 A DNA alkylator. SGTC_752 1896-0090 130 µM 1.30743750639347 0.0953941319499662 no 349 0.0955320831237149 540 772567 SGTC_2621 lithochol-11-enic acid 100 µM 1.30706466468263 0.0954578857244169 no 350 0.0955953753638175 580 6708711 SGTC_2671 danthron 100 µM 1.30470617678898 0.0958619002873843 no 351 0.095996458702906 532 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1959 st077091 55.8 µM 1.30382643049191 0.0960129245364103 no 352 0.0961463843913737 561 821356 YKL052C ASK1 SGTC_2225 6654152 15.4 µM 1.30296511394223 0.0961609544156252 no 353 0.0962933359955465 447 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2428 5615643 7.78 µM 1.29976442814255 0.096712509404062 no 354 0.0968408603848707 527 2253075 SGTC_1134 3477-0009 42.5 µM 1.29947700807656 0.0967621522393352 no 355 0.0968901394453417 600 3973534 SGTC_2926 9010726 65.15 µM 1.29587097679868 0.0973865723775434 no 356 0.097509969924298 552 2994293 SGTC_3243 9134147 49.47 µM 1.29578270683286 0.0974018941762677 no 357 0.0975251787785801 546 24282180 SGTC_3029 9088683 49.47 µM 1.29259828015234 0.0979558264708086 no 358 0.0980750173787552 536 25236615 SGTC_1957 st077035 62.4 µM 1.29095523789817 0.098242535608412 no 359 0.0983595997609037 543 705593 SGTC_3047 9092122 49.47 µM 1.29023917437505 0.098367680073824 no 360 0.0984838142459196 537 17173831 SGTC_3067 9117431 49.47 µM 1.28846688074044 0.0986779209535535 no 361 0.0987917452558387 494 17150885 SGTC_177 1327-0068 8.361 µM 1.27925735896637 0.100301587071817 no 362 0.100403221548375 579 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1000 4048-0884 8.67 µM 1.27712789590516 0.100679777756839 no 363 0.100778548881333 569 13040088 SGTC_755 1995-0008 37.3 µM 1.27559874751916 0.1009519939769 no 364 0.101048698544255 584 689533 SGTC_2279 7948423 32.93 µM 1.27488943563165 0.101078446406148 no 365 0.101174189421033 518 1247112 SGTC_594 1487-1584 10.8 µM 1.27405626669338 0.101227126823836 no 366 0.101321737988027 573 5013332 SGTC_99 0109-0120 622.8 µM 1.27383284241906 0.101267024350057 no 367 0.101361331554542 509 759414 SGTC_582 0987-0078 156 µM 1.27307575875807 0.101402304184544 no 368 0.101495580021985 702 1625765 SGTC_2765 myclobutanil 7.74 µM 1.26856522369705 0.102211000333412 no 369 0.102298087113646 581 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1017 4239-0030 168 µM 1.26808716650809 0.10229698564244 no 370 0.102383412000736 602 1149593 SGTC_1312 1218-2183 165 µM 1.26689072820258 0.102512412469069 no 371 0.102597182227332 590 6744073 SGTC_626 0214-0009 33 µM 1.26370384627158 0.103087841093064 no 372 0.103168172043968 598 3437874 SGTC_2469 5655019 90.81 µM 1.26169009505662 0.103452654776505 no 373 0.103530161210689 604 2788239 SGTC_2202 7226349 200 µM 1.26142763672854 0.10350027099326 no 374 0.103577408174867 521 844334 SGTC_2714 st079313 56.9 µM 1.25673163352186 0.104354928199906 no 375 0.104425414661546 551 2939799 SGTC_407 eburnamonine 100 µM 1.25319663302488 0.105001652479762 no 376 0.105067077503324 510 3195 SGTC_1715 st032160 10.2275 µM 1.25279222102766 0.105075823724466 no 377 0.105140666690899 560 5289825 SGTC_1516 st013856 110 µM 1.25078861898413 0.105443854021847 no 378 0.105505804117968 553 5281404 A mutagen and neurotoxin. SGTC_586 0957-0265 8.15 µM 1.24787976881877 0.105979822228239 no 379 0.106037545289034 502 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_524 r073-0010 27.8 µM 1.24749417601117 0.106051016880569 no 380 0.106108177196516 571 2772106 SGTC_3085 9117376 49.47 µM 1.24707156620785 0.106129085919815 no 381 0.106185628817277 582 16480349 SGTC_65 0798-0905 34.986 µM 1.24696708085939 0.106148393979654 no 382 0.106204784122759 694 3602145 SGTC_1272 0839-0021 27 µM 1.24423923583336 0.106653376248081 no 383 0.106705763647998 614 5027250 SGTC_1250 0485-0349 40.2 µM 1.24378549596037 0.106737541088276 no 384 0.10678925993427 560 6842794 YDL195W SEC31 SGTC_1978 st071761 42 µM 1.23724906403351 0.107955315180064 no 385 0.107997315751528 555 5147680 SGTC_610 4215-0184 155 µM 1.23430284329471 0.108507471746543 no 386 0.108545038418209 629 5605015 SGTC_2105 5350118 200 µM 1.23162539044391 0.10901101757043 no 387 0.109044525910937 590 2133313 SGTC_3317 9138495 8.753 µM 1.21987690275251 0.111240397452467 no 388 0.111255771440907 626 17020139 SGTC_1291 0993-0025 5.79 µM 1.21918596505297 0.111372517953163 no 389 0.111386808827614 612 4353356 SGTC_170 4197-0004 226 µM 1.21321322359225 0.112519304073182 no 390 0.112524154830416 543 218692 SGTC_298 1391-0729 10 µM 1.2110922197581 0.112928566381328 no 391 0.112930031444293 573 3237558 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.21047865125822 0.11304715655722 no 392 0.113047638931582 578 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1677 st019204 53.9 µM 1.2101701837322 0.113106810548674 no 393 0.113106798328549 586 3945625 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.20949142301556 0.11323815397395 no 394 0.113237052127811 551 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3344 9148862 3.898 µM 1.20672691141383 0.113774224105794 no 395 0.113768665773512 620 4905352 SGTC_348 k064-0012 10.7 µM 1.20614431128499 0.113887427250779 no 396 0.11388092594047 567 5066323 SGTC_1427 4048-4900 550 nM 1.20041983797729 0.115004001442677 no 397 0.114988164076911 620 24132586 SGTC_1923 st058458 19.1 µM 1.20004476950876 0.115077430386029 no 398 0.115060976840942 679 3534982 SGTC_876 0720-0963 56.8 µM 1.19895875956608 0.115290231731581 no 399 0.115271990929693 664 765861 SGTC_2000 st075254 36.4 µM 1.19789663856309 0.115498622495724 no 400 0.115478629276095 584 17234175 SGTC_1995 st072814 61.1 µM 1.19722360959897 0.115630810893611 no 401 0.115609704936347 603 5769371 SGTC_604 1000-0114 314 µM 1.19633646769831 0.115805216972686 no 402 0.115782641561401 662 1572745 SGTC_2947 9072639 7.68 µM 1.19208613065473 0.11664339588126 no 403 0.116613737333281 671 16488146 SGTC_2350 9023895 38.85 µM 1.1913382960785 0.116791314961991 no 404 0.116760402802763 617 2997209 SGTC_1111 tnp00062 510.699 nM 1.1899743514972 0.117061440798567 no 405 0.117028236556595 626 676306 SGTC_2243 6634756 200 µM 1.18434732440145 0.118180539255234 no 406 0.118137801321812 579 885676 SGTC_2353 9059630 146.67 µM 1.18282494338902 0.11848460517967 no 407 0.118439266429712 612 4779114 SGTC_768 0384-0033 77.3 µM 1.18187856329806 0.118673904620317 no 408 0.118626944466263 669 3965305 YMR134W ERG29 SGTC_2308 7584454 197.62 µM 1.18167684857632 0.118714280167861 no 409 0.118666973963967 686 893577 SGTC_3321 9137793 26.8275 µM 1.18076958187184 0.118896000134731 no 410 0.118847135486586 663 4904192 SGTC_2432 5630864 12.22 µM 1.18052508084054 0.118945005781954 no 411 0.118895720588268 622 5714970 SGTC_2624 nerol 100 µM 1.17766770681748 0.119518770416998 no 412 0.119464552940474 611 637566 A natural product oil. SGTC_1411 3909-8223 150 µM 1.17504984402606 0.120046152263228 no 413 0.119987387522637 665 X1411 SGTC_2019 4016004 108 µM 1.17060730147042 0.120944874327304 no 414 0.120878330551068 580 45595336 SGTC_687 k029-0044 34.9 µM 1.16847185764886 0.121378553215771 no 415 0.121308242279807 681 5829338 SGTC_357 1325-0123 420 µM 1.16498983838589 0.122088045607599 no 416 0.122011553056272 614 1098503 SGTC_1611 st001856 99.4 µM 1.16217977246052 0.122662741127692 no 417 0.122581224629005 625 647478 SGTC_3307 9126885 69.2785 µM 1.15939164659137 0.123234822475588 no 418 0.123148290099451 677 24824909 SGTC_1013 4112-3890 241 µM 1.15919223844333 0.123275809542349 no 419 0.123188917238096 663 705171 SGTC_369 0957-0393 4.5 µM 1.15396018658892 0.124354638875675 no 420 0.124258245981903 594 6997992 SGTC_1113 artemisinin 1.17947 µM 1.15219853885243 0.124719365423575 no 421 0.124619748990832 699 2240 An anti-malaria and mitochondrial poison. SGTC_650 1328-0195 38 µM 1.15219231771476 0.124720654753602 no 422 0.124621026915119 675 2780821 SGTC_979 1426-2828 121 µM 1.14959163270169 0.125260462508492 no 423 0.125156053022653 703 747872 SGTC_2773 thioridazine 9.09 µM 1.14957020046449 0.125264917828959 no 424 0.125160468824889 674 5452 An antipsychotic. SGTC_2496 diffractaic acid 79.83 µM 1.1473813612448 0.125720515164651 no 425 0.125612020521723 688 94870 An apoptosis inducer which activates caspases. SGTC_562 3772-2733 112 µM 1.14669695917285 0.125863207408897 no 426 0.125753443836458 763 2876874 YIL048W NEO1 SGTC_1810 st050138 53 µM 1.14474243600014 0.126271331279266 no 427 0.126157933525315 626 3444541 SGTC_1747 st037496 66.6 µM 1.14442898265176 0.126336869173181 no 428 0.126222887165341 692 723305 SGTC_678 1218-2179 85.9 µM 1.1431959574049 0.126594904286407 no 429 0.126478620178253 612 6820081 YOR116C RPO31 SGTC_1986 st071812 45 µM 1.14019440969994 0.127224571653831 no 430 0.127102657995386 626 11838594 SGTC_1367 1812-0510 76.9 µM 1.13914128254711 0.127446013100947 no 431 0.127322115659261 654 1142582 YDR527W RBA50 SGTC_925 2064-1272 59.6 µM 1.1391283659952 0.127448730732109 no 432 0.127324808931704 631 6815817 SGTC_2885 9057732 51.95 µM 1.13835181284231 0.127612190880838 no 433 0.127486803380953 653 6471414 SGTC_3163 9099914 49.47 µM 1.13517355802877 0.128282714662168 no 434 0.128151303071623 632 16268368 SGTC_139 0099-0334 718.624 µM 1.13413539315034 0.128502267832511 no 435 0.128368879674085 783 97690 SGTC_3348 9149464 3.537 µM 1.13326226629927 0.128687120240448 no 436 0.128552066366081 686 1951442 SGTC_1255 0566-0045 221 µM 1.13214815933083 0.128923259105715 no 437 0.128786075317764 687 2788469 SGTC_924 2046-0044 21.3 µM 1.13059232446211 0.129253526360048 no 438 0.129113359795932 686 3623589 SGTC_157 1348-1695 65.819 µM 1.12967436875705 0.129448661671379 no 439 0.129306730660646 724 5380510 SGTC_236 1509-0011 5.31 µM 1.12815729575265 0.12977160216863 no 440 0.129626747659992 938 3107280 SGTC_757 1066-0008 322 µM 1.12798288860386 0.129808764077064 no 441 0.129663572878723 718 6842497 SGTC_2561 acetosyringone 100 µM 1.12517656733478 0.130407736008292 no 442 0.130257110357689 787 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_776 4476-4378 112 µM 1.12480227401328 0.130487768192524 no 443 0.130336415315163 645 2892008 SGTC_859 0439-0102 54.6 µM 1.11667672623134 0.132233566265109 no 444 0.132066286252272 753 610143 SGTC_5 0352-0601 109.883 µM 1.11543130677584 0.132502564829972 no 445 0.132332819998476 650 762456 SGTC_2830 7992007 71.43 µM 1.1138519412839 0.132844234433906 no 446 0.132671354826031 660 1952075 SGTC_3301 9125354 19.7965 µM 1.11376664838905 0.132862703391506 no 447 0.132689654203646 617 41905162 SGTC_254 nsc-64875 3.808 µM 1.11357617087981 0.132903954957135 no 448 0.132730526953929 688 56993 SGTC_2306 7482397 179.52 µM 1.11261362140424 0.133112548418133 no 449 0.132937203877876 692 891448 SGTC_2815 7968870 71.43 µM 1.11221371434866 0.133199278231863 no 450 0.133023136329655 720 2977326 YHR190W ERG9 SGTC_2497 7-hydroxyflavone 100 µM 1.10738801437371 0.134248917716897 no 451 0.134063102837981 638 5281894 SGTC_54 0159-0055 9 µM 1.10538448383287 0.134686370754989 no 452 0.13449651207937 693 3319099 SGTC_1297 1068-0111 14.1 µM 1.10299591341445 0.135209170836293 no 453 0.135014469912757 688 767057 SGTC_304 1310-0298 97 µM 1.10228789464085 0.135364405928102 no 454 0.135168265212653 718 1550234 SGTC_253 dyclonine 31.25 µM 1.10098803549718 0.135649721573628 no 455 0.135450932223672 765 3180 An oral anasthetic. SGTC_409 arachidonic acid 100 µM 1.10012537952056 0.135839299546495 no 456 0.13563874862841 709 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_32 0928-0142 34.1 µM 1.09913232707033 0.136057758101191 no 457 0.135855175594297 689 2244242 SGTC_2280 7785178 200 µM 1.09742762329309 0.136433331143395 no 458 0.136227251796065 680 2954328 SGTC_860 0443-0016 25.1 µM 1.09659822752642 0.136616316285627 no 459 0.136408531331951 717 5337942 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.09656199550376 0.136624313786533 no 460 0.136416454259901 741 23665772 A membrane-active detergent. SGTC_1609 st001574 46.4 µM 1.09413887933837 0.137159895382179 no 461 0.136947036456475 712 3960012 SGTC_1645 Cervolide 78 µM 1.09171283317841 0.137697559657063 no 462 0.137479671339713 680 23173 A fragrance. SGTC_447 ml7 120 µM 1.0902563669806 0.138021034102454 no 463 0.137800114897184 728 4216 Selective myosin light chain kinase inhibitor. SGTC_1192 1488-0095 21.4 µM 1.08902446640241 0.138295037816464 no 464 0.138071548296016 691 915875 SGTC_1831 st055328 12 µM 1.08857492769157 0.138395118100862 no 465 0.138170689094651 752 1103068 SGTC_200 k038-0079 37.545 µM 1.08681719383709 0.138786914131261 no 466 0.138558803752452 677 3436683 SGTC_2313 7726885 200 µM 1.08506654620956 0.139177880824827 no 467 0.13894609139854 693 726423 SGTC_837 0091-0265 12.5 µM 1.08292478158491 0.139657213006501 no 468 0.139420905593862 751 759367 SGTC_2902 5787006 60.46 µM 1.08251588984013 0.13974885143603 no 469 0.139511679352642 706 591003 SGTC_1873 rapamycin 2 nM 1.08216023458257 0.139828592049604 no 470 0.139590667318605 759 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1681 tripelennamine 100 µM 1.08078475621419 0.140137275825722 no 471 0.139896435413522 643 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1742 st038235 28.8875 µM 1.07892655449917 0.140555026639774 no 472 0.140310235035445 724 564103 YBR002C RER2 SGTC_912 3474-0017 2.18 µM 1.0784583570787 0.140660417433361 no 473 0.14041462805459 740 3360550 SGTC_974 1326-0144 138 µM 1.07686004366974 0.141020600234768 no 474 0.140771397956227 752 5411856 SGTC_1653 st012112 65 µM 1.07602326547412 0.141209418960535 no 475 0.14095842574141 690 720429 SGTC_201 4262-0159 12.803 µM 1.07375916472765 0.141721171560363 no 476 0.141465318203871 646 1341029 SGTC_499 genistein 192 µM 1.07335121728717 0.141813512937998 no 477 0.141556781653744 708 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1509 1326-1131 80 µM 1.07254852628411 0.141995325854304 no 478 0.141736865146844 698 768313 SGTC_1412 3909-8563 178 µM 1.07025503275828 0.142515681136782 no 479 0.142252264531255 807 23767530 SGTC_1498 4478-3555 97.6 µM 1.07016915567879 0.142535190225272 no 480 0.142271587635075 691 3437919 SGTC_1386 3228-0095 33.8 µM 1.06643004202305 0.143386373267174 no 481 0.143114643651345 713 870181 SGTC_1883 5-benzylidenerhodanine 20 µM 1.06275441861667 0.144226441924693 no 482 0.143946667633479 786 1273210 SGTC_1960 st011366 51.8 µM 1.06102361471794 0.144623166249985 no 483 0.14433958471526 735 3972846 SGTC_2246 7293507 91.5585 µM 1.05805958919909 0.145304268069425 no 484 0.145014138157253 769 887656 SGTC_2383 9036125 200 µM 1.05675175825618 0.145605478898598 no 485 0.145312448203987 715 79580 SGTC_2051 5263410 176 µM 1.05658653879426 0.145643560982068 no 486 0.145350163331888 768 227584 SGTC_2339 9000433 200 µM 1.05653461099603 0.145655531407451 no 487 0.145362018401612 655 2988954 SGTC_3206 9114350 49.47 µM 1.05394284745495 0.146253826647358 no 488 0.145954542140368 695 17087243 SGTC_632 0781-2353 4.65 µM 1.04736825203029 0.14777893252795 no 489 0.147464884201279 775 6811515 YHR007C ERG11 SGTC_789 1309-1135 70.6 µM 1.0428065327057 0.148843348394819 no 490 0.148518952571323 749 3092424 SGTC_2610 ononetin 44.17 µM 1.04215392043822 0.148996044558557 no 491 0.148670161443248 763 259632 SGTC_3046 9092212 49.47 µM 1.04190526122023 0.149054252583402 no 492 0.148727802320445 756 25236637 SGTC_3147 9097027 49.47 µM 1.03934774703412 0.149653816288431 no 493 0.149321518132219 803 25236841 SGTC_3328 9140624 29.0385 µM 1.03911353581371 0.149708803258928 no 494 0.149375968230996 800 4904392 SGTC_293 4049-0273 38.5 µM 1.03473603195621 0.150739012523538 no 495 0.150396101923223 720 1380311 SGTC_314 1671-0008 2.74 µM 1.03351698949223 0.15102674236434 no 496 0.150681012001302 802 3913060 SGTC_3138 9097216 49.47 µM 1.03243283870892 0.151282940667033 no 497 0.15093469746172 786 25237486 SGTC_2141 5621638 7.665 µM 1.03186708878542 0.151416749122454 no 498 0.151067192718001 774 2856238 SGTC_131 0141-0277 33.849 µM 1.03111658349847 0.151594376442086 no 499 0.151243075974553 766 1547771 SGTC_3339 9145883 14.936 µM 1.02940253935378 0.152000570447443 no 500 0.151645278174273 738 2030670 SGTC_190 3970-0790 3.722 µM 1.0293744007841 0.152007244748571 no 501 0.15165188684397 745 2832352 SGTC_1166 k206-0078 225 µM 1.02926835614571 0.152032399654284 no 502 0.151676794378247 791 5404595 SGTC_3094 9117742 49.47 µM 1.02677354470583 0.152624992857707 no 503 0.152263554669742 816 17149698 SGTC_1082 camptothecin 424.86 nM 1.02538981816445 0.152954329562293 no 504 0.152589645249069 672 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_455 paf C-16 10 µM 1.02138075644426 0.153911172848116 no 505 0.153537039463116 752 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1763 st044482 94.5 µM 1.01977395283657 0.154295778462497 no 506 0.153917839557438 798 88505 SGTC_898 1000-0849 28.3 µM 1.01948125771427 0.154365906538617 no 507 0.153987273287213 808 6751807 SGTC_1432 4049-0298 68.4 µM 1.01922509417794 0.154427299146227 no 508 0.154048057923998 769 741646 SGTC_1348 1493-0373 93.8 µM 1.0172082419805 0.154911225311369 no 509 0.154527188009747 779 3010129 SGTC_2437 5741531 144.16 µM 1.01439877855768 0.155586999296862 no 510 0.155196253456378 819 2262990 SGTC_1626 st003712 1.76 µM 1.01134288507376 0.156324252902571 no 511 0.155926173581741 730 24207035 SGTC_1393 3470-5649 58.2 µM 1.01076086529977 0.156464929289376 no 512 0.156065448936493 670 4108395 SGTC_3135 9127742 49.47 µM 1.00944493100087 0.156783302821872 no 513 0.156380649681514 726 3643468 SGTC_2302 7771753 200 µM 1.00781692397279 0.15717776793052 no 514 0.156771179824998 795 2203047 SGTC_209 4077-0173 175.592 µM 1.00770435315054 0.157205067874709 no 515 0.156798207281836 674 15993494 SGTC_1569 carminic acid 40.6 µM 1.00540409819528 0.157763593496638 no 516 0.157351153648663 823 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1424 4048-1941 275 µM 1.00494859123248 0.157874349700766 no 517 0.157460802470225 881 X1424 SGTC_878 0828-0289 13.7 µM 1.00364441047593 0.158191742668871 no 518 0.157775020179237 806 745350 YLR208W SEC13 SGTC_3330 9141424 71.43 µM 1.0017500162619 0.158653518798783 no 519 0.158232171753013 840 27261020 SGTC_199 4063-0024 41.6 µM 1.00041838506231 0.158978644699461 no 520 0.158554038172811 820 306215 SGTC_1237 0330-0133 46.1 µM 0.997117973252258 0.159786341059552 no 521 0.159353624944177 781 X1237 YHR072W ERG7 SGTC_312 4092-0653 6.84 µM 0.997048811957208 0.159803295290051 no 522 0.15937040876216 879 1148278 SGTC_2114 5491910 81.25 µM 0.996518987004417 0.159933215853152 no 523 0.159499023199352 798 2849228 SGTC_1369 1866-0067 208 µM 0.996185924047958 0.160014922948832 no 524 0.159579908643955 866 3531355 SGTC_1726 st035556 14.5795 µM 0.996029314180922 0.160053351957896 no 525 0.159617951147988 854 5919439 SGTC_948 3448-0295 75.3 µM 0.995894489469679 0.16008644014782 no 526 0.159650706517767 839 678569 SGTC_747 3448-8087 38.7 µM 0.99389614401988 0.160577391191252 no 527 0.160136715915941 813 5168703 SGTC_1588 farnesol 29.9 µM 0.993376110444112 0.160705313497691 no 528 0.160263349590771 801 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_97 0535-0701 19.132 µM 0.992769973497352 0.160854500214841 no 529 0.160411032929525 765 2832013 YGL099W LSG1 SGTC_2697 mebhydrolin 72.4 µM 0.987391618851985 0.162182218002219 no 530 0.161725345739307 842 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_971 1315-0384 26.7 µM 0.985910850649905 0.162549014401817 no 531 0.162088430904792 780 6769120 SGTC_479 n-linoleoylglycine 10 µM 0.985263118942508 0.162709631532137 no 532 0.162247421840556 776 6433346 An anti-infammatory. SGTC_2458 5808907 16.39 µM 0.985053142735616 0.162761721189159 no 533 0.16229898396699 886 2731747 SGTC_1238 0333-0287 48.8 µM 0.984894877237542 0.162800989926402 no 534 0.162337854970318 807 7226 SGTC_1140 3229-1848 2.98 µM 0.983551735697341 0.163134497373682 no 535 0.162667982914176 840 2849525 SGTC_2619 obliquin 87.91 µM 0.983078312274637 0.163252156074503 no 536 0.162784448685535 878 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2157 5649910 96.377 µM 0.981193935579102 0.163721021707262 no 537 0.163248557091413 812 2858091 SGTC_706 4262-0057 46.9 µM 0.979778238678331 0.164073846150639 no 538 0.163597798073936 799 883298 SGTC_2193 5925765 200 µM 0.978757042329431 0.164328657907518 no 539 0.163850019914309 794 877370 SGTC_2521 angolensin 13.4 µM 0.978379714843414 0.16442287459448 no 540 0.163943278572581 783 821428 A flavenoid. SGTC_597 k018-0003 82.8 µM 0.978025407304222 0.164511375193048 no 541 0.164030879066134 904 6786234 SGTC_611 3453-1652 23.7 µM 0.977121539218987 0.164737287418066 no 542 0.164254492751437 857 1560575 SGTC_1186 1319-0216 26 µM 0.976153120063936 0.164979556407928 no 543 0.164494295386984 876 4565136 SGTC_2568 diosmetin 100 µM 0.975506506097399 0.165141447918346 no 544 0.164654538003336 852 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3203 9113543 49.47 µM 0.975486194853657 0.165146534871099 no 545 0.164659573134185 772 17018012 SGTC_2943 9068529 45.32 µM 0.971102584027666 0.166246783563834 no 546 0.165748598585124 926 3270634 SGTC_1118 chelidonine 707.474 nM 0.969201964144355 0.166725290806679 no 547 0.166222215646036 900 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2249 haloperidol 116.36 µM 0.968292574329433 0.166954556244453 no 548 0.166449136131178 945 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2071 5230951 39.92 µM 0.96693204205793 0.167297938269082 no 549 0.166789003670226 890 1799272 SGTC_1921 5740136 50 µM 0.965691196331779 0.167611509439716 no 550 0.167099363030624 875 1774243 SGTC_100 0086-0128 49.5915 µM 0.965623469637552 0.167628635379613 no 551 0.167116313488187 878 93297 SGTC_61 0978-8327 98.565 µM 0.965604436140383 0.167633448552205 no 552 0.167121077340973 871 6150059 YHR072W ERG7 SGTC_3107 9121808 49.47 µM 0.964734120972249 0.167853628107974 no 553 0.167339000169987 805 662681 SGTC_309 k408-0051 1.48 µM 0.963946173575825 0.168053130091997 no 554 0.167536456379739 881 3640463 SGTC_3280 9140961 49.47 µM 0.961753400416414 0.168609125565934 no 555 0.168086745548042 806 4901226 SGTC_521 r062-0005 13.8 µM 0.960466033805736 0.168936098092439 no 556 0.168410358931119 815 2832033 SGTC_3352 9151559 45.5865 µM 0.95766886646994 0.169647941154765 no 557 0.169114880376887 815 17159339 SGTC_2205 7238770 200 µM 0.957390880118369 0.169718790059634 no 558 0.169184999934765 854 279867 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.956571810691172 0.169927652246727 no 559 0.169391711345123 895 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_484 loperamide 105 µM 0.954798518423291 0.170380404960169 no 560 0.169839798396546 769 3955 An opioid-receptor agonist. SGTC_3044 9093193 49.47 µM 0.95379700891252 0.170636449052004 no 561 0.170093201877245 853 25236277 SGTC_1778 st046819 58.9 µM 0.950766888685134 0.171412623200246 no 562 0.17086136226754 906 671715 SGTC_2734 clemastine 41.6 µM 0.949249682375857 0.171802106517565 no 563 0.171246819233285 746 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1797 st048695 56.8 µM 0.94571706075388 0.172711156909034 no 564 0.172146459146934 858 592262 YIL048W NEO1 SGTC_3229 9132204 49.47 µM 0.943391011598446 0.173311390762946 no 565 0.172740469497703 866 17682924 SGTC_1850 st056238 17 µM 0.941424485789546 0.173819884897218 no 566 0.173243685236562 918 5393177 SGTC_1062 mesoridazine 14.2 µM 0.940344056072464 0.174099660322093 no 567 0.173520554101618 867 4078 A neuroleptic. SGTC_2816 7982706 58.44 µM 0.939449084216981 0.174331628388546 no 568 0.173750111007117 808 2981853 SGTC_970 1315-0089 19.5 µM 0.938793508722639 0.174501671774002 no 569 0.173918386172235 818 6811083 YLR033W RSC58 SGTC_3062 9077494 49.47 µM 0.937865701377349 0.174742506722043 no 570 0.174156715714621 841 16459633 SGTC_3313 9133968 57.047 µM 0.937457186762523 0.174848613492979 no 571 0.174261718267666 917 1494643 SGTC_944 3370-0224 231 µM 0.937408788580173 0.174861187049041 no 572 0.174274160959159 854 4580514 SGTC_2133 5320837 200 µM 0.936943639365246 0.174982059270571 no 573 0.174393774982195 795 2841355 SGTC_247 mechlorethamine 29.705 µM 0.936010183509128 0.175224784092592 no 574 0.17463397227351 822 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_704 1310-0270 142 µM 0.934738458030009 0.175555811981716 no 575 0.174961551127192 890 5718033 SGTC_113 0099-0221 2.5 µM 0.931160802108873 0.176489193570265 no 576 0.175885195376429 841 89219 SGTC_949 1165-0505 146 µM 0.930932907540733 0.17654875557919 no 577 0.175944135404003 914 6244267 SGTC_387 norethindrone acetate 66.7 µM 0.929917146957893 0.176814387053838 no 578 0.176206992112454 824 541197 SGTC_80 0159-0065 512.242 µM 0.927896251148913 0.177343622205529 no 579 0.1767306946138 806 1548079 SGTC_1476 4112-3294 3.34 µM 0.923612692814054 0.17846870962064 no 580 0.177844001471043 906 704369 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.922624492852085 0.178728899738941 no 581 0.17810146358023 828 6708760 SGTC_68 0986-0284 82.829 µM 0.922601755657081 0.178734889184294 no 582 0.178107390212326 721 423278 YIL048W NEO1 SGTC_1041 0206-0046 107 µM 0.919996260089056 0.179422067149563 no 583 0.17878735680355 884 50494 SGTC_1482 3346-2049 8.48 µM 0.919515554624603 0.17954903050355 no 584 0.178912986761373 870 3826804 SGTC_1933 st074711 15.9 µM 0.919073747853117 0.179665769766012 no 585 0.179028499724155 939 17250958 SGTC_1968 st069590 43.6 µM 0.918944917053542 0.179699819899794 no 586 0.179062192124482 862 6384066 SGTC_2119 5528445 120.635 µM 0.917311728706975 0.18013182496968 no 587 0.179489656547878 911 791935 SGTC_140 0062-0056 502.533 µM 0.914715401697035 0.180819936739538 no 588 0.180170528345605 973 3758964 SGTC_1608 st001473 40.5 µM 0.912263413230705 0.181471304786109 no 589 0.180815034627859 845 7292267 SGTC_905 2-aminofluorene 215 µM 0.90870610741902 0.182418906702832 no 590 0.181752639738985 953 1539 An established DNA mutagen. YPR165W RHO1 SGTC_305 1682-2595 20.8 µM 0.908371160166373 0.182508289550379 no 591 0.181841078761736 917 226033 SGTC_1697 st025554 27.742 µM 0.906145080612075 0.183103028163593 no 592 0.182429533522503 870 1269519 SGTC_2706 st078239 82.5 µM 0.904501622621737 0.183542883437556 no 593 0.182864737176955 911 15434492 SGTC_1654 st012436 41.8 µM 0.903313948271197 0.183861162285452 no 594 0.183179647893902 869 4323132 SGTC_1730 st033808 45.1 µM 0.902442544360828 0.184094903908624 no 595 0.183410914803948 981 1045166 SGTC_306 1672-3436 11.6 µM 0.900365743173155 0.184652721459433 no 596 0.183962822500713 928 6797378 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.900307451647082 0.184668393395272 no 597 0.183978328317109 844 2374 Ca(2+)-ATPase inhibitor. SGTC_2979 9012552 45.46 µM 0.899532724586121 0.184876760738476 no 598 0.184184486585602 867 17100905 SGTC_29 0299-0004 12.984 µM 0.896704787132075 0.185638590334417 no 599 0.184938232752492 824 16871 A napthoquinone isolated from Swertia calycina. SGTC_2023 5144124 124 µM 0.895266684636774 0.186026752674054 no 600 0.185322272494627 902 2830192 SGTC_448 monastrol 171 µM 0.894134967650198 0.18633257114925 no 601 0.185624841051972 942 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3092 9117248 49.47 µM 0.893850425203993 0.186409510669661 no 602 0.185700962680294 987 17141857 SGTC_1085 doxorubicin 7.67 µM 0.892897378261482 0.186667355341871 no 603 0.185956065621594 992 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2785 7756463 72.73 µM 0.892679650648615 0.186726292019645 no 604 0.186014375446353 929 2201551 SGTC_724 3910-0327 137 µM 0.892208380187275 0.186853899643869 no 605 0.186140625622287 927 2885483 SGTC_3282 9108498 15.4605 µM 0.892096006054079 0.186884335565145 no 606 0.186170737734144 869 16459645 SGTC_425 3825-7017 13.1 µM 0.891862558921336 0.186947573253936 no 607 0.186233302582053 941 3397440 SGTC_3070 9117005 49.47 µM 0.891718637488851 0.186986566230995 no 608 0.186271880644095 889 8779016 SGTC_3285 9112818 20.8695 µM 0.890729506958212 0.187254689831867 no 609 0.186537150488938 959 17017947 YPR165W RHO1 SGTC_2993 9054257 71.4286 µM 0.890723109529568 0.187256424756154 no 610 0.186538866943605 949 6470217 YGL055W OLE1 SGTC_723 4182-0001 115 µM 0.888722280725361 0.187799518846089 no 611 0.187076176815505 876 744821 YLR208W SEC13 SGTC_2871 9038510 12.99 µM 0.887265895067106 0.18819544334917 no 612 0.187467881330353 968 4945164 SGTC_1705 st027868 56.3335 µM 0.886796893159451 0.188323053032606 no 613 0.187594130305907 958 292948 SGTC_2376 9072922 81.32 µM 0.885720802464164 0.188616045832048 no 614 0.187883997860469 934 17087968 SGTC_513 4245-1575 41.7 µM 0.885331811576825 0.188722027518482 no 615 0.187988848720804 989 719745 SGTC_1642 st009582 77.7 µM 0.884963994762176 0.188822274023228 no 616 0.188088025418882 908 6739311 SGTC_3113 9123498 49.47 µM 0.880674334525752 0.189993819624314 no 617 0.189247056046302 987 8897275 SGTC_1836 st055642 81 µM 0.877433959477612 0.190881751325645 no 618 0.190125487280668 970 8571 SGTC_2897 9048598 12.99 µM 0.876351627539474 0.191178899577821 no 619 0.19041945329532 912 6467404 SGTC_1967 st070177 51.4 µM 0.874639908973693 0.191649420999926 no 620 0.190884932848912 915 5729214 SGTC_2244 6635614 200 µM 0.873774371468368 0.191887611840916 no 621 0.191120569994896 800 836499 SGTC_2140 5586273 200 µM 0.873541825865875 0.191951637897297 no 622 0.191183909458663 934 854421 SGTC_3227 9130768 49.47 µM 0.872360489186774 0.192277093533059 no 623 0.19150587400872 970 17720899 SGTC_821 1114-0266 29.2 µM 0.87165691442649 0.192471087084118 no 624 0.191697785832196 921 3123235 SGTC_1365 1672-3266 55.4 µM 0.871045478653235 0.192639772704139 no 625 0.191864660815204 963 6415873 SGTC_3078 9116413 49.47 µM 0.869942868379409 0.192944194015166 no 626 0.192165813388813 941 17177322 SGTC_1058 3448-5425 97.3 µM 0.869149007080924 0.193163554173468 no 627 0.192382817250771 924 7279705 SGTC_380 3970-0968 6 µM 0.86909707673762 0.193177908895514 no 628 0.192397017752606 908 2891601 SGTC_1036 k216-0215 33.5 µM 0.868867294999642 0.193241433582649 no 629 0.192459859922273 925 622330 SGTC_2572 astragaloside iv 100 µM 0.86840193427817 0.193370124695204 no 630 0.192587168166755 917 45006101 An anti-inflammatory agent. SGTC_1993 st073995 70.8 µM 0.866614276464476 0.193864970669373 no 631 0.193076694293775 966 3098394 SGTC_923 1900-2434 73.3 µM 0.866516629443592 0.193892022795358 no 632 0.19310345548564 918 5910570 SGTC_3055 9094636 49.47 µM 0.86392673193266 0.194610367361183 no 633 0.193814070420779 925 25236176 SGTC_1361 1608-0041 5.61 µM 0.863435428109103 0.19474681991719 no 634 0.193949053803771 950 X1361 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.861781980603325 0.195206468493085 no 635 0.194403751290642 859 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_843 0310-0051 143 µM 0.86122079181748 0.195362625372722 no 636 0.194558225400686 935 2065037 SGTC_1784 st039334 36.3 µM 0.860891434835718 0.195454307860844 no 637 0.194648919732732 949 3496984 SGTC_1387 3342-1166 1.8 µM 0.859856915399462 0.195742455016213 no 638 0.194933960404967 890 3418228 SGTC_1404 3909-7820 48.3 µM 0.856783506113804 0.196600018678599 no 639 0.195782271403398 973 23741373 SGTC_1791 st048313 56.1 µM 0.856737157122773 0.196612968688003 no 640 0.195795081605044 916 1204976 SGTC_1500 4488-1866 171 µM 0.85660827330915 0.196648981823568 no 641 0.195830705931256 1043 2900003 SGTC_2242 6630449 61.2675 µM 0.856100187122761 0.196790991844692 no 642 0.195971182579677 864 691249 YDR170C SEC7 SGTC_2314 7727897 200 µM 0.855390865547576 0.196989350967224 no 643 0.196167399394041 949 900724 SGTC_2216 7189485 200 µM 0.851706727637938 0.198021551635645 no 644 0.197188442841028 995 731273 SGTC_389 tpck 16.7 µM 0.850107502752914 0.198470628103975 no 645 0.197632660347547 957 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3211 9128781 49.47 µM 0.84622518799123 0.199563369705557 no 646 0.198713566565145 890 17194361 SGTC_2401 5128683 200 µM 0.846207817901244 0.199568266926469 no 647 0.198718410706674 937 708373 SGTC_1293 1000-1278 195 µM 0.846032484141974 0.199617703543828 no 648 0.198767311477752 988 678847 SGTC_72 0744-0168 198.391 µM 0.845797392127711 0.199684000995551 no 649 0.19883289027378 938 677577 SGTC_2526 patulin 37.61 µM 0.845074056545327 0.199888069329874 no 650 0.199034746147384 998 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2651 TUB2.036 5 µM 0.844761676401148 0.199976237168272 no 651 0.199121957910686 1116 15992207 YFL037W TUB2 SGTC_1707 st032323 6.317 µM 0.844302539872051 0.200105868745383 no 652 0.199250183590923 961 3132057 YMR211W DML1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.84355622376375 0.200316689710964 no 653 0.199458717634715 1008 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1406 3909-7906 11.9 µM 0.842132494226405 0.200719237787666 no 654 0.199856897281741 989 X1406 SGTC_96 0929-0093 37.281 µM 0.840844016149594 0.20108396285124 no 655 0.200217662441706 933 6991579 SGTC_2802 7925815 54.55 µM 0.839794914346566 0.201381221871648 no 656 0.200511692706308 957 1262923 SGTC_1848 st056003 16.4 µM 0.838518292524672 0.201743302863795 no 657 0.200869839238551 1071 146492 SGTC_3123 9126162 49.47 µM 0.838040667585081 0.201878869068446 no 658 0.201003931891363 1011 25239884 SGTC_414 piperonyl butoxide 100 µM 0.836964630255283 0.202184484839335 no 659 0.20130622482983 966 5794 A potent inhibitor of cytochrome P450. SGTC_2759 disulfiram 3.38 µM 0.836428927012417 0.202336738248195 no 660 0.201456822383283 965 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.83619350232374 0.202403670505288 no 661 0.201523026610174 993 442882 SGTC_2718 lomofungin 53.02 µM 0.836190373237118 0.202404560207294 no 662 0.201523906634381 966 5351222 A RNA synthesis inhibitor. SGTC_2868 9035608 32.47 µM 0.835773596249774 0.202523084480108 no 663 0.201641141556307 1003 6462614 SGTC_1820 st053765 18.6 µM 0.835475253182717 0.202607953639944 no 664 0.201725087362996 987 3690829 SGTC_174 3553-0389 74.3 µM 0.834009198193216 0.203025308670862 no 665 0.202137900294338 941 738071 SGTC_2182 6325192 200 µM 0.829832675071459 0.204217088128806 no 666 0.203316696946641 954 736248 SGTC_2485 5633444 17.78 µM 0.828560389734633 0.204580963582816 no 667 0.203676604801944 957 5724239 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.826538878910588 0.205159911413632 no 668 0.204249236447765 1029 688751 SGTC_1383 3049-0032 20.7 µM 0.824944348719031 0.205617260796356 no 669 0.204701593247229 1043 712864 SGTC_2349 9023730 187.07 µM 0.823407271400983 0.20605870369604 no 670 0.20513821470881 995 4126287 SGTC_2727 riluzole 51.77 µM 0.82064922033701 0.206852213240441 no 671 0.205923051446394 1001 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3289 9119912 71.43 µM 0.819663744962711 0.20713617904572 no 672 0.206203911710191 1003 17014829 SGTC_412 gemfibrozil 100 µM 0.819467360153263 0.207192795085688 no 673 0.206259908460942 985 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_649 1123-0311 367 µM 0.81829860702326 0.207529925766273 no 674 0.206593350660717 1028 693629 YIL048W NEO1 SGTC_149 3970-0822 46.1 µM 0.818250518094849 0.207543804116111 no 675 0.206607077140648 1103 3114250 YBL034C STU1 SGTC_3273 9137859 49.47 µM 0.817460756113017 0.20777180599725 no 676 0.206832583677744 1058 2377234 SGTC_2286 7945697 125 µM 0.815398318681526 0.20836792263131 no 677 0.207422173214534 1029 1245733 SGTC_2056 5235370 200 µM 0.814993342769818 0.208485093231627 no 678 0.207538060371325 957 5511916 SGTC_1746 st038117 42 µM 0.814300414359983 0.20868566644933 no 679 0.207736436204895 983 2898218 SGTC_1977 st070720 65.3 µM 0.813705316763156 0.208858012565855 no 680 0.207906893798789 957 682188 SGTC_343 4130-2827 29.8 µM 0.81369631123125 0.208860621300415 no 681 0.207909473944834 1009 1118244 SGTC_1607 st000305 50.6 µM 0.812324458492498 0.209258245607802 no 682 0.208302739842122 1018 5457690 SGTC_1084 voriconazole 435 nM 0.81037290110094 0.209824661396295 no 683 0.208862943878251 1060 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_463 ikarugamyin 104 µM 0.809129208736274 0.210186097691328 no 684 0.209220414437347 1049 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_105 0111-0055 734.78 µM 0.808473827967422 0.210376708541818 no 685 0.20940893326923 930 5179370 SGTC_1016 4226-1401 38 µM 0.805577135105837 0.211220396945165 no 686 0.210243356924759 1065 2901613 SGTC_1214 0358-0031 63.7 µM 0.805515846708871 0.211238269143782 no 687 0.210261032777115 989 4301366 SGTC_2755 lomerizine 42.69 µM 0.8054335081027 0.211262281150544 no 688 0.21028478097923 1060 3949 A calcium channel blocker. SGTC_1318 1280-3875 124 µM 0.80377643892307 0.211745863999762 no 689 0.210763049632738 1022 373245 SGTC_255 tunicamycin 200.472 nM 0.802500239712359 0.212118738646796 no 690 0.211131824897395 1025 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1070 indatraline 8.81 µM 0.801723718795575 0.212345807085052 no 691 0.211356396191169 1015 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1218 1348-1416 30.7 µM 0.800708152678535 0.212642990827431 no 692 0.21165031085036 1062 6787668 SGTC_1310 1188-0297 994 nM 0.796197470537707 0.213965877437766 no 693 0.212958633774073 1019 1588352 SGTC_812 4251-0442 148 µM 0.794380495661122 0.214500107998486 no 694 0.213486977661875 1055 5723007 SGTC_445 e6 berbamine 66 µM 0.792548981542523 0.21503939743519 no 695 0.214020321630362 1097 6610268 A calcium/calmodulin antagonist. SGTC_1363 1636-0063 10.4 µM 0.791123886919196 0.215459560705375 no 696 0.214435850651757 1092 6072185 SGTC_246 cycloheximide 667 µM 0.790630621149628 0.215605102026297 no 697 0.214579786278434 965 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1321 1326-2144 215 µM 0.789563064583495 0.21592028676659 no 698 0.214891492975279 1056 3513030 SGTC_172 1112-0046 2.638 µM 0.789470177611793 0.215947723278111 no 699 0.214918626678464 946 2802135 YIL048W NEO1 SGTC_301 4119-0100 24.5 µM 0.788443733867709 0.216251043807039 no 700 0.215218599040106 1067 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1002 4049-0206 172 µM 0.787840582822475 0.216429393700858 no 701 0.215394979803248 1111 4662749 SGTC_3121 9125696 49.47 µM 0.787624210449687 0.216493395080854 no 702 0.215458274476399 1105 1235365 SGTC_966 1300-0360 30.2 µM 0.786029488145385 0.216965440062292 no 703 0.215925105835587 1019 70588 SGTC_1197 1601-0112 267 µM 0.785640216162685 0.217080756585431 no 704 0.21603914837603 1073 7350313 SGTC_1696 st025591 34.7925 µM 0.785534471210727 0.217112088202977 no 705 0.216070133828231 1075 2787147 SGTC_83 0170-0301 39.027 µM 0.785193791883083 0.217213047283479 no 706 0.216169977402314 1014 3089716 SGTC_3172 9105863 49.47 µM 0.784909455823884 0.217297329998803 no 707 0.216253328792261 1038 2348785 SGTC_1207 2099-0101 141 µM 0.782918166185669 0.217888115871232 no 708 0.216837584497706 1113 5837381 SGTC_49 0717-0965 32.132 µM 0.782230985884564 0.218092206781136 no 709 0.217039418720345 1161 5889349 YGL099W LSG1 SGTC_1425 4048-4433 7.33 µM 0.781421255481579 0.21833283613923 no 710 0.217277386853673 1129 23734946 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.780035895449332 0.218744881096474 no 711 0.21768487352234 1015 279621 SGTC_2534 helenine 20.12 µM 0.779975522165974 0.218762847975994 no 712 0.217702641604177 1048 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1564 D-Arginine 115 µM 0.779832027927241 0.218805554771051 no 713 0.217744875849964 1056 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_523 1934-0222 13.7 µM 0.77958767062823 0.218878291497522 no 714 0.217816807706631 1059 1361595 SGTC_674 0498-0004 451 µM 0.779038040039543 0.219041948360974 no 715 0.217978653436092 1031 4231473 SGTC_3178 9107506 49.47 µM 0.778739753496888 0.219130794993426 no 716 0.218066516726254 1044 8897194 SGTC_1646 st011709 75.6 µM 0.777817533996441 0.219405615233887 no 717 0.218338294818038 1052 5757843 SGTC_3081 9117243 49.47 µM 0.774280656516759 0.220461434574281 no 718 0.219382420043848 1082 45595589 SGTC_483 fpl-64176 144 µM 0.77391762477508 0.220569970382629 no 719 0.219489753134719 1090 3423 SGTC_2588 indole-3-carbinol 100 µM 0.772916432142085 0.22086945610825 no 720 0.219785919606652 1081 3712 Induces cell cycle arrest. SGTC_1266 0828-0227 32.9 µM 0.77172368507035 0.221226545016786 no 721 0.220139049760144 1040 3913820 SGTC_2118 5526350 200 µM 0.771700147367421 0.221233595140183 no 722 0.22014602171283 1071 743594 SGTC_2967 9089538 49.85 µM 0.769239249836896 0.221971403550202 no 723 0.220875646927842 1107 728216 SGTC_3088 9117578 49.47 µM 0.769189662927655 0.22198628476265 no 724 0.220890363039123 1144 678341 SGTC_1676 st018489 23.4 µM 0.768767130311983 0.222113111447225 no 725 0.221015782551501 1043 3696235 SGTC_509 pifithrin 175 µM 0.768517680581988 0.222188005273613 no 726 0.221089845345721 1134 4817 A p53 inhibitor. SGTC_1581 himbacine 57.9 µM 0.768388017662436 0.222226940461052 no 727 0.221128348483254 1058 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3184 9108758 49.47 µM 0.767757783641847 0.222416242603718 no 728 0.221315549815612 1068 902885 SGTC_1246 0422-0085 105 µM 0.766656932009558 0.222747123762152 no 729 0.221642758207337 1098 264295 SGTC_2396 5342950 42.78 µM 0.765639798934889 0.223053090953455 no 730 0.221945328319917 1087 1886677 SGTC_2798 7813637 45.45 µM 0.765067183760479 0.223225446475624 no 731 0.222115769861102 1061 956368 SGTC_1243 0416-0003 5.65 µM 0.763431225662332 0.223718282631221 no 732 0.222603131728528 1079 2141977 SGTC_1356 1502-0781 85.8 µM 0.762069026238494 0.224129119923583 no 733 0.223009403958868 1033 567702 SGTC_2128 5255449 168.493 µM 0.762068337650686 0.224129327708928 no 734 0.223009609435019 1130 736008 SGTC_401 neomycin 50 µM 0.761630457098812 0.224261482846023 no 735 0.223140295810417 1058 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3247 9135149 49.47 µM 0.761406607594055 0.224329059137144 no 736 0.223207121006791 1034 8934436 YOR116C RPO31 SGTC_1764 st044502 93.5 µM 0.761390566871603 0.224333901997421 no 737 0.223211910038318 1096 8407 SGTC_2116 5511452 16.8835 µM 0.760464027838899 0.224613734430986 no 738 0.223488631777569 1081 870744 SGTC_1112 tnp00069 1.16933 µM 0.760246064088158 0.224679592392831 no 739 0.223553757548385 1136 145826 SGTC_3043 9092303 49.47 µM 0.759836651715907 0.224803326346005 no 740 0.223676115762544 1068 25236084 SGTC_2725 haloperidol 53.21 µM 0.759772550215974 0.224822702809695 no 741 0.223695276776938 1093 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_41 0478-0632 82.643 µM 0.759239990954908 0.224983720287818 no 742 0.223854503760541 1136 3750424 SGTC_476 mead acid 10 µM 0.758340624013755 0.225255789146408 no 743 0.224123546756804 1107 5312531 An omega 9 fatty acid. SGTC_3093 9117344 49.47 µM 0.758303284990902 0.225267088658156 no 744 0.224134720585745 1043 24824913 SGTC_788 1182-0090 188 µM 0.758250874155431 0.225282949733935 no 745 0.224150405239332 1161 5715185 SGTC_2661 dactinomycin 12.96 µM 0.757294974716001 0.225572344239268 no 746 0.22443658045537 1117 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_770 0389-1121 67.2 µM 0.754761148655603 0.226340466401522 no 747 0.225196154534038 1143 6753108 SGTC_1449 4112-4002 201 µM 0.754038967461561 0.226559663819046 no 748 0.225412911727365 1087 2059539 SGTC_1575 cyproterone acetate 48 µM 0.753575086115643 0.226700524901807 no 749 0.225552204465126 1077 9880 An androgen receptor antagonist and liver toxin. SGTC_2524 avocatin b 10.57 µM 0.753007702574398 0.226872882384444 no 750 0.225722642706978 1062 6710748 SGTC_2281 7943571 200 µM 0.751077407363393 0.227459812853183 no 751 0.226303035803375 1167 1244024 SGTC_1700 st030840 7.9285 µM 0.750938427433709 0.227502104423782 no 752 0.226344856215655 1106 5499307 SGTC_964 1287-0107 19.4 µM 0.750174048960989 0.227734783813303 no 753 0.226574943140691 1117 51516812 YPR165W RHO1 SGTC_994 3910-0338 138 µM 0.749477892883074 0.227946812572329 no 754 0.226784609153547 1146 3479481 SGTC_1177 0983-0204 23.6 µM 0.749211247456186 0.228028054367154 no 755 0.226864945536786 1138 766818 SGTC_2745 rifampicin 24.3 µM 0.747808272209941 0.228455782434387 no 756 0.227287905885737 1023 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_644 1498-1197 63.3 µM 0.747738069482641 0.228477197125972 no 757 0.227309081839255 1144 6741615 SGTC_3224 9130643 49.47 µM 0.746977171895722 0.228709374224695 no 758 0.227538670326694 1129 17644395 SGTC_1481 3346-2004 36 µM 0.744496250547276 0.22946731155761 no 759 0.228288154359382 1159 2770522 SGTC_2158 5657123 3.6195 µM 0.743831138111853 0.229670746667697 no 760 0.228489319820442 1108 2858827 SGTC_1981 st071826 47 µM 0.743597067959671 0.22974236473321 no 761 0.228560138797217 1087 11838600 SGTC_993 3909-8757 62.7 µM 0.742315937503202 0.230134571619358 no 762 0.228947968909946 1046 4288324 YLR208W SEC13 SGTC_322 k048-0136 19.3 µM 0.741311060099867 0.230442468002967 no 763 0.229252428582671 1131 6823282 SGTC_935 2996-0153 430 µM 0.739946220549395 0.230861026024751 no 764 0.229666313598451 1146 23738523 SGTC_2505 galangin 7.89 µM 0.737853344198819 0.231503676341474 no 765 0.230301786585321 1032 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1273 0849-0096 14.1 µM 0.737700561278696 0.231550629748572 no 766 0.230348215486778 1129 5286025 SGTC_1974 st069448 26.9 µM 0.737506381875532 0.231610312826286 no 767 0.230407231836282 1122 6323587 YNR016C ACC1 SGTC_824 1304-0008 100 µM 0.737008731369076 0.231763310070446 no 768 0.230558519812234 1119 768245 SGTC_1786 berberine 21.6 µM 0.736538693536575 0.231907869790783 no 769 0.230701464377133 1113 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_63 0099-0242 26.702 µM 0.736504820593675 0.231918289323905 no 770 0.230711767487929 1160 3898502 YLR359W ADE13 SGTC_808 0711-0032 135 µM 0.73640889611888 0.231947797718243 no 771 0.230740946167049 1128 4252555 SGTC_1160 4092-0570 10.5 µM 0.735487553905322 0.232231328498453 no 772 0.23102130857777 1125 4994975 SGTC_795 0685-0265 78 µM 0.734332604163208 0.232587021130633 no 773 0.23137302567021 1197 302754 SGTC_750 4073-0104 132 µM 0.733306320956585 0.232903342001123 no 774 0.231685810328855 982 22330957 SGTC_1963 st076565 50.3 µM 0.73211445874616 0.233270997338716 no 775 0.232049354725957 1164 4914280 SGTC_1173 0443-0020 122 µM 0.731944684336331 0.233323394074271 no 776 0.232101165513133 1143 5331295 SGTC_1871 st057448 67.3 µM 0.731793434705154 0.23337007908839 no 777 0.232147328437112 1202 691747 SGTC_3099 9120367 49.47 µM 0.73087877937785 0.233652508843094 no 778 0.232426599399727 1174 24824940 SGTC_810 3825-7150 143 µM 0.73039429058889 0.233802187347753 no 779 0.232574603633624 1193 22330411 YGL099W LSG1 SGTC_1152 3909-8331 15.9 µM 0.729877593927546 0.233961874728138 no 780 0.232732504623191 1126 16001939 SGTC_128 0906-2981 13.371 µM 0.728954172757985 0.234247412534018 no 781 0.233014847757678 1090 6740226 SGTC_481 bay k-8644 50 µM 0.728919725457874 0.234258067966457 no 782 0.233025383964054 1103 2303 A calcium channel antagonist. SGTC_395 anisomycin 6.25 µM 0.728696514128335 0.234327119450885 no 783 0.233093662797771 1089 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2271 7849410 118.62 µM 0.728444495955085 0.23440509600708 no 784 0.233170766799023 1148 972430 SGTC_2667 digitoxin 100 µM 0.728100058698362 0.234511691028116 no 785 0.233276168961721 1115 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1316 1272-0050 65.9 µM 0.726267318335949 0.235079330665907 no 786 0.233837455160661 1150 7340392 SGTC_2626 ethyl orsellinate 100 µM 0.726010985464012 0.235158782998004 no 787 0.233916018039808 1149 75653 A natural product. SGTC_338 4055-0136 114 µM 0.725785330045246 0.235228738891498 no 788 0.23398519075793 1138 2900563 SGTC_3356 9151811 4.48 µM 0.725195991258737 0.235411495185503 no 789 0.234165900899208 1125 1859254 YPR165W RHO1 SGTC_635 k038-0028 24.7 µM 0.723382595253845 0.235974327706828 no 790 0.234722430590881 1165 4035102 SGTC_3269 9137823 49.47 µM 0.722651191890472 0.236201546616443 no 791 0.23494710445238 1095 17682936 SGTC_129 0088-0017 176.636 µM 0.721453908131299 0.236573756596899 no 792 0.235315144674636 1099 182446 SGTC_2197 6588183 93.1375 µM 0.721264758753483 0.236632588609557 no 793 0.235373317532359 1154 884136 SGTC_3276 9139060 49.47 µM 0.721041089325018 0.236702167939648 no 794 0.235442117267273 1215 4870619 SGTC_2803 7707263 71.43 µM 0.718663032212904 0.237442631975597 no 795 0.236174283038978 1130 2199229 SGTC_471 1-acyl-paf 4 µM 0.717474787728221 0.237813095756414 no 796 0.236540593867961 1130 16759367 SGTC_3104 9120930 49.47 µM 0.713063506765 0.239191187539618 no 797 0.23790323007283 1160 17014836 SGTC_2553 4-methylesculetin 85.09 µM 0.712306385817025 0.239428151424857 no 798 0.238137535275899 1195 5319502 SGTC_2869 9037858 32.47 µM 0.710089599143032 0.240122698437501 no 799 0.23882428783785 1150 27187042 SGTC_2132 5317594 122.667 µM 0.710066188728437 0.240130039069107 no 800 0.238831546076219 1142 794577 SGTC_2184 6075246 200 µM 0.708413655381943 0.240648520752198 no 801 0.239344207445156 1177 2267320 SGTC_1405 3909-7894 12 µM 0.708098234516168 0.240747553135167 no 802 0.23944212795758 1174 7104060 SGTC_2687 chenodiol 100 µM 0.707291855589121 0.241000831938214 no 803 0.239692562875914 1165 5702181 A cholesterol synthesis inhibitor. SGTC_1863 st057641 20.1 µM 0.705122410653251 0.241682960403368 no 804 0.240367030540689 1202 3921635 SGTC_2822 7994718 71.43 µM 0.704232532334443 0.241963063517397 no 805 0.240643987195664 1134 1018011 SGTC_2137 5261020 140 µM 0.703351212827769 0.242240646076018 no 806 0.240918451214749 1188 763655 SGTC_366 0181-0206 4.31 µM 0.702957468822057 0.242364716416453 no 807 0.241041127543876 1196 274874 SGTC_1785 bathophenanthroline 24 µM 0.70211743020002 0.242629531060155 no 808 0.241302966563843 1117 72812 An iron chelator. SGTC_569 4130-2812 160 µM 0.70195262445431 0.24268150297084 no 809 0.241354354444411 1096 743552 SGTC_1337 1486-1011 40.3 µM 0.701419620054592 0.242849628520556 no 810 0.241520590605162 1215 X1337 SGTC_1331 1472-0049 76.2 µM 0.70125787775789 0.242900659346936 no 811 0.241571047921276 1173 24051409 SGTC_2488 5268135 45.7 µM 0.700567871049808 0.243118426448759 no 812 0.24178636750219 1181 1270356 YLR208W SEC13 SGTC_2961 9083290 32.55 µM 0.700464380479582 0.2431510973225 no 813 0.241818671162464 1148 17741490 SGTC_1329 1447-1697 50.6 µM 0.699802327727594 0.2433601565004 no 814 0.242025380437834 1172 2840515 SGTC_2344 7990960 76.95 µM 0.69763208432705 0.244046143932655 no 815 0.242703655638146 1184 140813 SGTC_830 4076-0286 57.8 µM 0.696162481248318 0.244511259123788 no 816 0.243163540490867 1237 6866659 SGTC_1307 1187-1599 12.2 µM 0.695733468779444 0.244647127423392 no 817 0.24329788072657 1193 1538471 SGTC_1156 4092-0367 4.88 µM 0.693414544277497 0.245382234375874 no 818 0.244024718717009 1193 1357585 SGTC_2585 alliin 100 µM 0.69154551902798 0.245975584604648 no 819 0.244611392782505 1268 87310 A garlic compound which reacts with lipids. SGTC_1436 4092-1007 8.32 µM 0.690303496776883 0.246370308645503 no 820 0.245001674672644 1181 2881121 SGTC_814 3342-0569 96 µM 0.689880080775357 0.246504951002038 no 821 0.24513480163477 1238 4346283 SGTC_3110 9122132 49.47 µM 0.689448032550503 0.246642378953258 no 822 0.245270682759524 1271 918317 SGTC_510 ag-490 170 µM 0.687643577753946 0.247216791811109 no 823 0.245838629419559 1300 5328779 SGTC_3231 9132313 49.47 µM 0.687380586922724 0.247300569480537 no 824 0.245921463883245 1207 4905967 SGTC_1685 st024049 53.0905 µM 0.687071523946066 0.24739904316806 no 825 0.246018828873508 1207 1941139 SGTC_2085 5307070 144.047 µM 0.685922132863224 0.247765446133174 no 826 0.246381106223231 1178 2840351 SGTC_3162 9099653 49.47 µM 0.685576556537573 0.247875665601912 no 827 0.246490084537928 1187 25237511 SGTC_2821 7996764 71.43 µM 0.684474919826516 0.248227200559632 no 828 0.246837660619579 1286 2987135 SGTC_3131 9127911 49.47 µM 0.683825397028271 0.24843458937887 no 829 0.247042713658994 1258 45595681 SGTC_3340 9146634 11.102 µM 0.681973166978522 0.249026502342851 no 830 0.247627959090479 1215 4907387 SGTC_1651 st011928 86.1 µM 0.681401794331525 0.249209245927361 no 831 0.247808643906856 1225 720198 SGTC_2674 ligustilide 100 µM 0.679350329702797 0.249865958402519 no 832 0.248457956886679 1191 5319022 A signalling regulator. SGTC_2426 5582046 32.21 µM 0.677847470228065 0.250347634387556 no 833 0.248934204574457 1229 2251934 SGTC_1030 k029-0042 36.7 µM 0.677384611316286 0.250496082686957 no 834 0.249080979749432 1227 6080581 SGTC_2927 9011802 47.9 µM 0.677334925854824 0.25051202060026 no 835 0.249096738025676 1208 43912568 SGTC_2374 9071832 200 µM 0.676920287901164 0.25064504753535 no 836 0.249228265571492 1196 17381698 SGTC_1034 k072-0165 12.7 µM 0.676759384500415 0.250696679721098 no 837 0.249279315777185 1232 5835461 SGTC_2267 7931562 200 µM 0.676695349424905 0.250717229460914 no 838 0.24929963388482 1153 934880 SGTC_764 1951-2361 146 µM 0.676262904510209 0.250856030354852 no 839 0.249436870205927 1202 5438930 SGTC_1732 st034308 51.822 µM 0.675984761940957 0.250945326654928 no 840 0.249525159916025 1143 830119 SGTC_1394 3474-0001 65.7 µM 0.675645170983229 0.251054373460531 no 841 0.249632977456415 1164 5017666 YIL048W NEO1 SGTC_3355 9151058 44.0485 µM 0.673585364494958 0.251716339339011 no 842 0.250287480221698 1241 17015728 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.670577975617318 0.252684485306259 no 843 0.251244708476046 1253 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2635 hydroquinidine 100 µM 0.668904478154209 0.253224069719952 no 844 0.25177820670533 1233 442912 An experimental heart treatment. SGTC_1745 st081495 74 µM 0.667742840344345 0.253598971594101 no 845 0.252148879371708 1195 13842402 YBL026W LSM2 SGTC_315 k915-0449 187 µM 0.666248270258075 0.25408175110285 no 846 0.252626212083381 1276 20970215 YNL149C PGA2 SGTC_1992 st073643 23.3 µM 0.664911856839596 0.254513850414771 no 847 0.253053435784411 1236 3161292 SGTC_1431 4049-0260 9.09 µM 0.663415961181251 0.254997971000975 no 848 0.253532093123743 1235 3854841 SGTC_1477 0139-0234 16 µM 0.663386670642493 0.255007455180861 no 849 0.253541470268956 1252 620880 SGTC_1493 4348-0038 111 µM 0.659922979947488 0.256130286767562 no 850 0.254651628246458 1296 800424 SGTC_1474 0330-0125 5.35 µM 0.658886518170414 0.256466779166756 no 851 0.25498432192562 1259 X1474 SGTC_2539 epi(13)torulosol 80 µM 0.658447658644492 0.256609326439801 no 852 0.255125259868339 1233 6708597 SGTC_953 1188-0045 9.7 µM 0.657721986641746 0.256845124620817 no 853 0.255358395819165 1237 6144426 SGTC_1419 3993-2473 62.6 µM 0.657024005063611 0.257072031485897 no 854 0.25558274070518 1283 704026 SGTC_1081 sertraline 6 µM 0.655665086217699 0.257514101378476 no 855 0.256019818866534 1257 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2804 7954240 19.48 µM 0.654867132489656 0.257773867594845 no 856 0.256276651650088 1265 828705 SGTC_3228 9131799 49.47 µM 0.654698336240512 0.257828835025024 no 857 0.256330998334793 1248 17015818 SGTC_375 3970-0961 9.27 µM 0.653953475784189 0.258071466743084 no 858 0.256570889934116 1231 2898222 SGTC_1139 k015-0024 46.9 µM 0.65319181722415 0.258319692684797 no 859 0.256816312435842 1250 2766652 SGTC_2468 5987765 72.9 µM 0.653190944513044 0.258319977173918 no 860 0.256816593711888 1301 26772094 SGTC_2721 ifenprodil 61.44 µM 0.652933040905029 0.258404056519368 no 861 0.256899723440657 1273 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2066 5222451 176 µM 0.652568200952729 0.258523022472176 no 862 0.257017345729399 1266 2281147 SGTC_2992 9074591 71.4286 µM 0.652375579454473 0.25858584337094 no 863 0.25707945708279 1271 17741321 SGTC_1740 st038286 13.222 µM 0.651032978177542 0.259023934098429 no 864 0.257512599443967 1285 716786 SGTC_653 0203-0016 55.2 µM 0.650940162902771 0.259054233896226 no 865 0.257542556980622 1293 295302 SGTC_1583 clindamycin 39.6 µM 0.650563858643094 0.259177098217367 no 866 0.257664033427491 1201 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2942 9052777 62.25 µM 0.649957788667197 0.259375044950274 no 867 0.257859744086651 1353 6469503 SGTC_2312 7706453 155.7 µM 0.649259134083685 0.259603327344375 no 868 0.258085447620396 1292 976098 SGTC_838 0109-0203 71.4 µM 0.648539033728015 0.259838725560719 no 869 0.258318186474907 1269 759422 SGTC_656 4090-1979 187 µM 0.648416965675838 0.259878640081296 no 870 0.258357650058106 1284 22330961 SGTC_3221 9128209 49.47 µM 0.647588481695365 0.260149626143835 no 871 0.258625574547912 1295 16460723 SGTC_1020 4335-0961 93.3 µM 0.645749563223833 0.260751631868434 no 872 0.259220778345044 1223 669075 SGTC_351 caspofungin 25 nM 0.645415455889947 0.260861085299586 no 873 0.25932899501017 1310 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2724 maprotiline 69.64 µM 0.644120720058881 0.261285463378494 no 874 0.259748577625537 1263 4011 A tricyclic antidepressant. SGTC_1043 0916-0009 19.3 µM 0.64382201000512 0.261383422482971 no 875 0.259845429746412 1313 3101130 SGTC_2407 paclitaxel 400 µM 0.643303601668382 0.261553474299617 no 876 0.260013559856469 1399 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_48 0382-0018 55 µM 0.642295337921977 0.261884374372763 no 877 0.260340720374192 1372 762596 SGTC_3259 9138485 49.47 µM 0.641809993365751 0.262043735147446 no 878 0.260498280118016 1389 17646153 SGTC_571 k831-0106 44.2 µM 0.64075965922106 0.262388777900944 no 879 0.260839423188586 1280 4783639 SGTC_2091 4-phenylthiadiazole 200 µM 0.640703539943274 0.262407220055522 no 880 0.260857656903741 1284 270010 SGTC_3208 9114115 49.47 µM 0.640335039640697 0.262528334670203 no 881 0.2609774026263 1246 650895 SGTC_947 3447-0010 211 µM 0.639589177597729 0.262773563916489 no 882 0.261219860106829 1290 748350 SGTC_2120 5538279 151.968 µM 0.639477596102161 0.262810260459798 no 883 0.261256141869742 1321 2058197 SGTC_3063 1327-0034 4 µM 0.637613703997762 0.263423638274415 no 884 0.261862586370705 1202 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2227 7312221 64.1025 µM 0.636685615079248 0.263729330171791 no 885 0.262164822666159 1294 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1891 st059073 26.2 µM 0.636506831255595 0.263788238373352 no 886 0.262223064941835 1323 688754 SGTC_853 0419-0306 21 µM 0.636462136661887 0.263802966023204 no 887 0.262237626102648 1231 762713 SGTC_2589 lobaric acid 100 µM 0.636167668470997 0.263900008919365 no 888 0.262333571967415 1270 73157 A novel microtubule depolymerizer. SGTC_2043 5101342 149 µM 0.635054664634189 0.264266967057626 no 889 0.262696381668383 1273 678451 SGTC_936 3005-4620 401 µM 0.634530501512892 0.264439873954981 no 890 0.26286733379983 1344 777207 SGTC_1556 plumbagin 1.48 µM 0.631710418310118 0.265371128464752 no 891 0.263788059513136 1233 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2966 9084041 48.03 µM 0.63139895618566 0.265474082191555 no 892 0.263889849174728 1211 17741380 SGTC_1098 clofazimine 15.1 µM 0.631073667865304 0.265581627794299 no 893 0.263996178779849 1344 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1925 st057770 10.1 µM 0.629630143236138 0.266059146948868 no 894 0.264468298554444 1224 5989122 SGTC_3013 9080133 71.4286 µM 0.628845371797104 0.26631893233829 no 895 0.264725146405019 1377 17050193 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.628528899870514 0.266423731358131 no 896 0.264828760383172 1296 4330530 SGTC_1712 st032288 53.4 µM 0.626295414548037 0.267163938087386 no 897 0.265560596717876 1281 2883011 SGTC_3146 9095609 49.47 µM 0.625411625422316 0.267457123943981 no 898 0.265850467029418 1354 17173999 SGTC_98 0074-0023 107.663 µM 0.623573239872327 0.268067504446755 no 899 0.26645394469315 1268 3563821 SGTC_3197 9113331 49.47 µM 0.622279833915826 0.26849736072533 no 900 0.266878939514276 1375 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_111 0083-0039 52.457 µM 0.620737508062066 0.26901039672817 no 901 0.267386173162783 1232 759313 SGTC_842 0271-0008 11.1 µM 0.620360657212003 0.269135826355895 no 902 0.267510184174666 1365 1221709 SGTC_2298 7976326 193.81 µM 0.619984768336434 0.269260965028325 no 903 0.267633907512 1196 2235818 SGTC_1381 2324-0066 62.1 µM 0.619846380677692 0.269307043567229 no 904 0.267679464894026 1325 10885928 SGTC_2834 9001755 58.44 µM 0.619826670423361 0.269313606755369 no 905 0.267685953851177 1310 2989575 SGTC_3239 9133757 49.47 µM 0.618396856600293 0.269789924918129 no 906 0.268156884691557 1332 17036923 SGTC_1868 st057644 42.7 µM 0.617988295453767 0.269926107566157 no 907 0.268291527043831 1303 688665 SGTC_1944 st076371 56.9 µM 0.616868281266024 0.270299609923187 no 908 0.268660804849123 1289 24208455 SGTC_2973 9094665 17.96 µM 0.615621129339718 0.270715813999348 no 909 0.269072301314263 1368 25237061 YIL048W NEO1 SGTC_2098 5376439 882.5 nM 0.613365479675076 0.271469389443383 no 910 0.269817353030896 1372 2844116 SGTC_2754 granisetron 64.02 µM 0.612664701461568 0.271703720482767 no 911 0.270049033504751 1356 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_475 α-linolenic acid 10 µM 0.6101962916497 0.272529925445333 no 912 0.270865892999649 1395 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2100 5377183 190 µM 0.60975729020908 0.27267699478465 no 913 0.271011298779208 1349 2844202 SGTC_784 4579-0127 173 µM 0.609568286501337 0.272740324813771 no 914 0.271073912456457 1438 1948547 SGTC_1526 st051518 75 µM 0.608709318050403 0.273028233821796 no 915 0.271358564803545 1328 673993 SGTC_3240 9133527 49.47 µM 0.608052378808148 0.273248528316525 no 916 0.271576367450543 1287 17617455 SGTC_2405 ticlatone 3.52 µM 0.607941352982653 0.27328576781974 no 917 0.271613185721242 1222 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1054 3429-0080 167 µM 0.606466868390464 0.273780567341775 no 918 0.272102388347501 1355 1162877 SGTC_3320 9137005 35.139 µM 0.605896050559457 0.273972238174698 no 919 0.272291891109771 1318 4908713 SGTC_1319 1306-0155 43.7 µM 0.604543080383969 0.274426807074974 no 920 0.272741318201398 1359 3122360 SGTC_1908 st060353 56.5 µM 0.603927097296631 0.274633887398085 no 921 0.272946056166602 1403 4227716 SGTC_404 fumagillin 50 µM 0.603146666555473 0.274896362133616 no 922 0.273205561970033 1346 12015870 A methionine aminopeptidase binder. SGTC_488 nitrendipine 139 µM 0.601129358364302 0.275575396160691 no 923 0.273876915312197 1375 4507 Dihydropyridine L-type calcium channel blocker. SGTC_58 0957-0393 9 µM 0.599873071923486 0.275998683581018 no 924 0.274295414918441 1284 6997992 SGTC_3022 9087993 49.47 µM 0.599010227080428 0.276289591425971 no 925 0.274583032336753 1382 17173644 SGTC_2852 9023854 51.95 µM 0.596157585165182 0.277252428174616 no 926 0.275534978819933 1413 19798528 SGTC_486 niguldipine 82 µM 0.595765010876881 0.277385060003154 no 927 0.275666110540319 1352 1236 A calcium channel blocker. SGTC_769 0302-0231 76 µM 0.595344775317321 0.277527071602809 no 928 0.275806515954986 1353 571869 YER009W NTF2 SGTC_2123 5259487 200 µM 0.594762991195144 0.277723734470656 no 929 0.276000954539147 1345 2173474 SGTC_1776 st049249 45.9 µM 0.59307508623202 0.278294688775217 no 930 0.276565451415326 1316 1822314 SGTC_2825 7998094 58.44 µM 0.588867947885186 0.27972028991511 no 931 0.277974930240972 1361 2987815 SGTC_259 usnic acid 108.925 µM 0.588706702703897 0.279774998749981 no 932 0.278029020400794 1399 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_33 0986-0033 35.816 µM 0.587522808508583 0.280176840803012 no 933 0.278426318307934 1331 2848082 SGTC_1142 3253-1408 9.78 µM 0.587469685623719 0.280194878536479 no 934 0.278444152069155 1355 256655 SGTC_2563 tomatine 8.54 µM 0.587452497580775 0.280200714810954 no 935 0.278449922346604 1391 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3101 9120531 49.47 µM 0.58541880628155 0.280891678932348 no 936 0.279133073239357 1410 24824904 SGTC_1761 st044296 37 µM 0.585334066061332 0.280920488017082 no 937 0.279161556569945 1343 1826700 SGTC_2090 5301565 104.445 µM 0.585215548433003 0.280960782783508 no 938 0.279201395711222 1388 2056344 SGTC_2186 6124449 200 µM 0.584504353908717 0.281202640212507 no 939 0.279440518422529 1353 3834182 YLR033W RSC58 SGTC_978 1416-0512 87.4 µM 0.584119891416798 0.281333427038643 no 940 0.279569826450049 1392 6814003 SGTC_337 1315-0038 354 µM 0.583643864415136 0.281495403041508 no 941 0.279729971027404 1348 1626437 SGTC_1530 rhein 70.4 µM 0.581238439776294 0.282314575615109 no 942 0.280539881886919 1389 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1781 st038725 66.3 µM 0.578981703381011 0.2830841533794 no 943 0.281300759449034 1374 4270275 YIL048W NEO1 SGTC_469 w7 172 µM 0.578348491621622 0.283300267926586 no 944 0.281514430931609 1397 45115570 A P450 inhibitor. SGTC_3353 9151644 39.2805 µM 0.577341242164539 0.283644204116127 no 945 0.281854479235777 1361 4909158 SGTC_1435 4092-0789 56.7 µM 0.576671166953095 0.283873119258508 no 946 0.282080806797084 1443 2248285 SGTC_1733 st037357 54.9 µM 0.576150385000509 0.284051092985363 no 947 0.282256768822127 1313 1272339 YGL099W LSG1 SGTC_3319 9138450 16.7555 µM 0.575591558929803 0.284242127381866 no 948 0.2824456439412 1354 2029690 SGTC_406 estrone 100 µM 0.574338379922661 0.284670749132143 no 949 0.282869421152671 1465 5870 A steroid. SGTC_320 4092-0846 5.34 µM 0.572845092538112 0.285181897102731 no 950 0.283374792212553 1412 1359356 SGTC_2695 st077686 51.995 µM 0.57255334293988 0.285281813202737 no 951 0.283473579128025 1335 2876092 SGTC_1269 0831-0796 3.05 µM 0.572474444109309 0.285308836716229 no 952 0.283500297242859 1395 927758 SGTC_346 4513-0042 7.16 µM 0.572155826562497 0.285417978310975 no 953 0.283608205417167 1378 2827372 SGTC_847 0342-0274 5.54 µM 0.571516406356751 0.285637069970838 no 954 0.283824821161516 1405 18097 SGTC_2812 7970281 58.44 µM 0.571359310526216 0.285690909706596 no 955 0.283878052476878 1475 2233435 SGTC_2336 9001819 198.65 µM 0.571037318429895 0.285801277623062 no 956 0.283987173187493 1479 2989602 SGTC_2038 4100038 30.985 µM 0.566225677421464 0.28745295480851 no 957 0.285620188377357 1403 3596803 SGTC_1710 st031758 61.5 µM 0.565579820203941 0.287674999405301 no 958 0.285839724535443 1453 5394341 SGTC_1222 0366-0074 1.18 µM 0.564531923345311 0.28803543688298 no 959 0.286196090363183 1437 286520 SGTC_1254 0550-0035 264 µM 0.564015794301025 0.288213044358621 no 960 0.286371691610683 1463 15121435 SGTC_285 1486-1325 46 µM 0.563915862427078 0.288247438331572 no 961 0.286405697081976 1423 22310230 SGTC_1734 st037168 69.4 µM 0.563089186986932 0.288532032909357 no 962 0.286687077080358 1389 708907 SGTC_1352 1496-0991 99 µM 0.563018926543075 0.288556227152839 no 963 0.286710998050724 1385 3000039 SGTC_1226 3909-7979 35.4 µM 0.561328515386998 0.28913860960988 no 964 0.28728680290293 1440 6615510 SGTC_2236 dapsone 200 µM 0.55978143835171 0.289672094322808 no 965 0.28781426293994 1388 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1193 1488-0126 41.5 µM 0.559536771372655 0.28975650609939 no 966 0.287897721508599 1397 1384710 SGTC_2365 9042475 200 µM 0.559001137202625 0.289941343823032 no 967 0.288080472036342 1390 6464479 SGTC_977 1348-1378 135 µM 0.558894221743161 0.289978245044726 no 968 0.288116956577319 1365 X977 SGTC_2178 5812956 200 µM 0.557722193833489 0.290382907663256 no 969 0.288517050042804 1396 5403383 SGTC_4 0960-0234 25.671 µM 0.557426380795433 0.290485083930541 no 970 0.288618072672477 1394 6821112 SGTC_709 3807-1509 243 µM 0.556914308723708 0.290661997620548 no 971 0.288792988949589 1432 1886677 YPL242C IQG1 SGTC_215 1287-0124 461.5 µM 0.554034200858726 0.291657971972665 no 972 0.289777719872844 1483 5560863 SGTC_1638 st008370 60.6 µM 0.553956403870137 0.291684897116423 no 973 0.289804341096846 1375 24207134 SGTC_2088 5278280 127.392 µM 0.550407937417617 0.292914233075154 no 974 0.291019802854779 1423 791502 SGTC_1590 st077108 57.8 µM 0.549658696452231 0.293174108360424 no 975 0.291276745727107 1405 5489485 SGTC_161 4065-0411 162.148 µM 0.54925812896407 0.293313089600784 no 976 0.291414158790452 1459 1906281 YLR208W SEC13 SGTC_1951 sophoraflavanone G 9.2 µM 0.548147106214193 0.29369873071625 no 977 0.291795448857365 1393 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1097 itavastatin 7.23 µM 0.548025418947584 0.293740983181967 no 978 0.291837224629434 1421 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_325 2810-4341 181 µM 0.547737817126235 0.293840855968436 no 979 0.291935970668222 1493 774970 SGTC_941 3237-0776 460 µM 0.547432819881305 0.293946786659309 no 980 0.292040706298379 1491 760008 SGTC_2177 5811945 192 µM 0.546627102740196 0.294226710729514 no 981 0.292317472551366 1479 5343475 SGTC_805 3852-0218 479 µM 0.546611272036426 0.29423221190174 no 982 0.292322911667269 1370 6615355 SGTC_1905 st060207 84.5 µM 0.546192754253063 0.294377664131175 no 983 0.292466723145632 1413 1948547 SGTC_2850 9015429 58.44 µM 0.545030126632679 0.294781899396264 no 984 0.292866398825412 1406 6457570 SGTC_1057 3448-5381 134 µM 0.544850135571614 0.294844503555032 no 985 0.292928296881895 1486 5497911 SGTC_530 4358-1714 28 µM 0.544551414943892 0.294948417536332 no 986 0.293031038859969 1463 1564641 SGTC_1674 st016616 23.6 µM 0.543871909575596 0.295184855432379 no 987 0.293264810191177 1358 625830 SGTC_515 4092-1064 102 µM 0.543078973534015 0.295460872472569 no 988 0.29353771450507 1529 717353 SGTC_614 0462-0418 107 µM 0.542776405580772 0.295566226133888 no 989 0.293641880123473 1332 5188303 SGTC_3300 9124615 50.48 µM 0.542315942682632 0.295726591689132 no 990 0.29380043734842 1489 24824903 SGTC_1982 st072467 71.9 µM 0.541960911444376 0.295850265818886 no 991 0.293922716946084 1412 3163533 SGTC_698 k064-0052 127 µM 0.541761679070332 0.295919678258372 no 992 0.293991346721616 1485 5088751 SGTC_927 2425-1185 123 µM 0.540892032735976 0.296222750044187 no 993 0.294291001381785 1383 730375 SGTC_701 4424-0219 185 µM 0.540141223474775 0.296484521570294 no 994 0.294549821676295 1489 2911779 SGTC_341 1486-1430 230 µM 0.538144152701027 0.297181320747342 no 995 0.295238766166951 1387 2054753 YPL210C SRP72 SGTC_2622 2-methoxyxanthone 59.94 µM 0.536732788738007 0.297674211611051 no 996 0.295726101871983 1531 71034 A hepatoprotective. SGTC_2856 9022925 19.48 µM 0.53564212598889 0.298055359258671 no 997 0.296102954330424 1449 4944862 SGTC_1540 guanosine 70.6 µM 0.534739213519627 0.298371063048679 no 998 0.296415100800029 1404 6802 Guanosine is a purine nucleoside SGTC_1618 st003135 44.5 µM 0.534249665692695 0.298542297296309 no 999 0.296584405740346 1411 1270615 SGTC_988 1497-1057 103 µM 0.533628821348897 0.298759520763884 no 1000 0.296799181884093 1474 3533044 SGTC_2797 7859098 81.82 µM 0.531478667896669 0.299512379550576 no 1001 0.297543559962042 1438 972681 SGTC_2022 5136654 200 µM 0.531464321447639 0.299517405730211 no 1002 0.297548529530212 1452 1713771 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.530446356125454 0.299874140423423 no 1003 0.297901246440655 1425 140250 A respiratory chain inhibitor. SGTC_688 0527-0193 473 µM 0.528831473122976 0.300440452526181 no 1004 0.298461181318509 1466 4007154 SGTC_807 1315-0151 48 µM 0.527442790866783 0.300927825858418 no 1005 0.298943067309619 1528 4011080 SGTC_1157 4092-0394 27.6 µM 0.52535444067687 0.301661425739836 no 1006 0.299668409285492 1545 3659885 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.525098666783115 0.3017513297676 no 1007 0.299757301434423 1502 5377381 SGTC_909 3448-9333 149 µM 0.52449586226832 0.301963262018039 no 1008 0.299966848490991 1415 3344074 SGTC_689 0833-0039 98 µM 0.524288723322509 0.302036102756217 no 1009 0.300038869482915 1472 5374726 SGTC_2419 paclitaxel 166.5 µM 0.524149570830052 0.302085040381059 no 1010 0.300087256377739 1385 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2596 sinensetin 100 µM 0.522791735370806 0.302562755346006 no 1011 0.300559595773235 1437 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_249 wiskostatin 11.211 µM 0.518739475009653 0.303990434228572 no 1012 0.301971214952563 1481 2775510 A n-wasp and actin depolymerizer. SGTC_1009 4106-0057 9.87 µM 0.518569337524851 0.304050442149956 no 1013 0.302030548039785 1452 2928005 SGTC_272 doxorubicin 8.13 µM 0.518428787936 0.304100018327648 no 1014 0.302079566707495 1445 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2208 7283366 200 µM 0.517548325125586 0.304410666665171 no 1015 0.302386721877903 1524 898663 SGTC_2583 asiatic acid 100 µM 0.516861436219112 0.304653115539003 no 1016 0.302626444755391 1455 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2037 5169046 200 µM 0.5158127352634 0.305023437535339 no 1017 0.302992603486999 1488 5718022 SGTC_2513 baicalein 25.65 µM 0.515732852839168 0.305051654168262 no 1018 0.303020502924729 1394 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_538 2922-0838 53.3 µM 0.515565084416166 0.305110918286128 no 1019 0.303079100840593 1584 777039 SGTC_2055 5235184 200 µM 0.515309689248076 0.305201146323065 no 1020 0.303168314631958 1470 2836034 SGTC_2343 7990716 14.84 µM 0.515264168046048 0.305217229658834 no 1021 0.303184217180045 1496 6456862 SGTC_2164 5685496 200 µM 0.514044380437633 0.305648339234263 no 1022 0.303610481209328 1472 759046 SGTC_158 k038-0087 26.446 µM 0.513197805276096 0.305947702822994 no 1023 0.303906480518333 1500 X158 SGTC_2982 9019404 25.97 µM 0.512875280611048 0.30606178723562 no 1024 0.304019282942591 1300 22333232 SGTC_1165 k072-0275 30.3 µM 0.512835999274209 0.306075683235879 no 1025 0.304033022794787 1467 6153523 YGL055W OLE1 SGTC_929 2805-0021 398 µM 0.512447749523438 0.306213043839903 no 1026 0.304168839936741 1500 3098024 SGTC_714 4296-0578 26.1 µM 0.51209384347457 0.306338277571258 no 1027 0.304292666543905 1485 1589775 SGTC_2670 beta-carotene 100 µM 0.511145977973506 0.306673802120717 no 1028 0.304624421492025 1422 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2680 butyl paraben 22.24 µM 0.510578960593678 0.306874591901491 no 1029 0.304822955653046 1482 7184 An antifungal and steroid mimetic. SGTC_1286 0929-0070 131 µM 0.509040525491713 0.307419667778869 no 1030 0.305361909218609 1524 1420408 SGTC_152 4469-0003 551.229 µM 0.507644928178044 0.307914503678393 no 1031 0.305851188291112 1483 697280 SGTC_2389 9091542 195.52 µM 0.506037655441386 0.30848482621274 no 1032 0.306415107733414 1458 3626624 YOL127W RPL25 SGTC_1052 3253-3998 198 µM 0.505337611933697 0.308733373377988 no 1033 0.306660864906492 1423 5450317 SGTC_1450 4112-4260 37.6 µM 0.505153348590083 0.308798809788544 no 1034 0.306725566829163 1531 1633175 SGTC_1913 st060213 96.1 µM 0.505150836618119 0.308799701893043 no 1035 0.306726448920419 1540 688959 SGTC_1216 1165-0504 9.65 µM 0.501355835228325 0.310148748719753 no 1036 0.308060358062376 1528 6304004 SGTC_1640 st009078 66.4 µM 0.499859226774718 0.310681467682079 no 1037 0.308587101841651 1553 690618 SGTC_2453 5731132 22.18 µM 0.499339888559413 0.310866419414684 no 1038 0.308769979416218 1592 1362040 SGTC_2987 9018338 71.43 µM 0.49699018097403 0.311703816678285 no 1039 0.309597987784166 1492 5055682 SGTC_1035 k081-0041 55.2 µM 0.496418542531989 0.311907686807374 no 1040 0.30979957266595 1490 731709 SGTC_1040 k898-0338 155 µM 0.495939028118607 0.312078746121874 no 1041 0.309968714686302 1628 20969351 SGTC_2399 5884133 200 µM 0.495526928584478 0.312225788610927 no 1042 0.31011410919193 1467 722445 SGTC_2285 7945142 200 µM 0.494006719112636 0.312768477761298 no 1043 0.310650717115349 1486 2970608 SGTC_1716 st033144 30.6155 µM 0.493902807567103 0.312805587271198 no 1044 0.310687410842783 1577 674617 SGTC_874 0599-0792 117 µM 0.492198831670718 0.313414391705295 no 1045 0.311289395152778 1610 765305 SGTC_1562 morin hydrate 59.1 µM 0.491594667948579 0.313630372383721 no 1046 0.311502956786464 1515 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3154 9100113 49.47 µM 0.491456785969345 0.313679672357494 no 1047 0.311551704621764 1444 25237525 SGTC_27 0485-0001 32.618 µM 0.490647397129949 0.313969138009017 no 1048 0.31183792864762 1475 2054479 SGTC_1278 0874-0585 172 µM 0.489196584416978 0.314488285693643 no 1049 0.312351263718582 1514 766306 SGTC_1695 st026914 34.495 µM 0.488708835076024 0.31466290066675 no 1050 0.312523923954879 1459 3289191 SGTC_2483 5729050 27.16 µM 0.485671720115716 0.31575112375192 no 1051 0.313599968682163 1634 2865180 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.482139092880876 0.317018904722002 no 1052 0.314853570297532 1543 688788 SGTC_2166 5933061 31.504 µM 0.481169788815501 0.317367143011843 no 1053 0.315197915376863 1662 2877375 SGTC_3347 9188721 44.724 µM 0.48051294024071 0.317603218525136 no 1054 0.315431352032026 1522 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1839 st053978 48 µM 0.480367090895271 0.317655647766868 no 1055 0.315483195262702 1521 3788398 SGTC_2939 9044578 71.43 µM 0.480127724475596 0.317741702015493 no 1056 0.315568287702556 1464 2653634 SGTC_565 1418-0001 44.5 µM 0.480033546965599 0.317775562324714 no 1057 0.315601769574749 1565 2862145 SGTC_1371 2421-0008 32.7 µM 0.479458337231941 0.317982404637168 no 1058 0.315806300277554 1524 2827552 SGTC_1483 3453-0561 55.9 µM 0.47900980148572 0.318143735082932 no 1059 0.315965827916759 1542 4546991 SGTC_2761 levamisole 97.89 µM 0.478652188297204 0.318272387005244 no 1060 0.316093042313333 1612 26879 An alkaline phosphatase inhibitor. SGTC_804 1595-0054 20.9 µM 0.478377841910499 0.318371098422797 no 1061 0.316190650819948 1492 761523 Stimulates phospholipase C. SGTC_3244 9134489 49.47 µM 0.478349346565041 0.318381351952448 no 1062 0.316200789789383 1457 16584271 SGTC_940 3232-1287 54.8 µM 0.477633582500282 0.318638952200785 no 1063 0.316455512138358 1501 1585493 YIL048W NEO1 SGTC_2720 fluspirilene 36.88 µM 0.477171817274383 0.318805185951298 no 1064 0.316619888943361 1541 3396 An atypical antipsychotic. SGTC_1164 k060-0068 93.7 µM 0.475956785666299 0.319242766907881 no 1065 0.31705258261544 1541 5963676 SGTC_1748 st037455 53.6035 µM 0.475353060859734 0.319460285826733 no 1066 0.317267672525679 1559 580690 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.474947766827206 0.319606346031143 no 1067 0.317412101854432 1478 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_907 3448-6986 75.5 µM 0.473810103504045 0.320016487571043 no 1068 0.31781766454378 1622 590582 SGTC_3118 9124250 49.47 µM 0.473018049953386 0.320302162542338 no 1069 0.318100150830405 1485 1504786 SGTC_1153 4055-0057 267 µM 0.471249211391509 0.320940525171432 no 1070 0.318731389930548 1489 882706 SGTC_1283 0922-0125 16.4 µM 0.471106878596806 0.320991915225072 no 1071 0.318782206630072 1621 3360884 SGTC_73 0327-0325 16.231 µM 0.471106788556939 0.320991947735556 no 1072 0.318782238777845 1596 53298 SGTC_71 0417-1750 47.813 µM 0.469789407340177 0.321467758279231 no 1073 0.319252741536548 1662 6811472 SGTC_1101 ebselen 5.29 µM 0.469704007253328 0.321498613128191 no 1074 0.31928325224137 1649 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2715 st079500 56.4 µM 0.469675923324467 0.321508760054232 no 1075 0.319293285993484 1472 28246688 SGTC_799 1310-0557 151 µM 0.46850959422732 0.321930280711076 no 1076 0.319710105790128 1548 5354492 SGTC_160 3453-0671 289.699 µM 0.468170459779862 0.322052889651564 no 1077 0.319831347590476 1448 5322268 SGTC_423 5-fluorouracil 457 µM 0.467515913771509 0.322289585644252 no 1078 0.320065404597967 1442 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_962 1254-0300 21.5 µM 0.466933283882448 0.322500336069128 no 1079 0.32027380561477 1542 7340576 SGTC_2381 9035592 200 µM 0.464502907382138 0.323380072993594 no 1080 0.321143738499335 1450 4749657 SGTC_76 0433-0009 400.328 µM 0.463690861866309 0.323674234173014 no 1081 0.321434622591363 1539 2841569 SGTC_2930 9013230 14.89 µM 0.462922272858623 0.323952754875964 no 1082 0.321710040974867 1634 2995857 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.462123023077541 0.324242490977195 no 1083 0.321996550379044 1506 803109 SGTC_2735 sertaconazole 140 nM 0.460388410863459 0.324871671465416 no 1084 0.322618725818234 1595 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_743 1275-0778 158 µM 0.460104697522083 0.324974627901699 no 1085 0.322720536231051 1631 2849257 YMR203W TOM40 SGTC_21 0849-0113 22.993 µM 0.459629030364731 0.325147272247994 no 1086 0.322891259007991 1525 1560156 SGTC_2914 7968218 45.32 µM 0.459109213490859 0.325335983755364 no 1087 0.323077870345839 1603 2977111 SGTC_2131 toluylene red 5.2905 µM 0.456170210840613 0.326403784834195 no 1088 0.324133792450859 1480 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1659 st012954 42.1 µM 0.454889891302191 0.32686939757863 no 1089 0.324594227851113 1567 24207262 SGTC_1448 4255-0083 152 µM 0.451463896661522 0.32811665104225 no 1090 0.325827620057983 1691 5399660 SGTC_631 k072-0230 41.5 µM 0.447696864144598 0.329490276409473 no 1091 0.327185992564187 1596 5773147 SGTC_472 calcifediol 10 µM 0.446811390811045 0.329813493966901 no 1092 0.32750562306881 1571 5283731 A vitamin D metabolite. SGTC_103 0844-0104 51.839 µM 0.446450687749394 0.329945195099482 no 1093 0.327635862807488 1625 5375804 SGTC_2570 licareol 100 µM 0.444162217521593 0.330781259744718 no 1094 0.328462653213517 1530 443158 SGTC_1771 st048882 4.1505 µM 0.44242878309614 0.331415111467981 no 1095 0.329089477246741 1500 4580403 SGTC_1015 4130-4525 82 µM 0.439504334741709 0.332485566707987 no 1096 0.330148070908261 1510 1363237 SGTC_621 3584-0052 32.1 µM 0.43915372590919 0.3326139943635 no 1097 0.330275076057264 1650 2273927 SGTC_2438 5259590 200 µM 0.438749921322137 0.332761931914586 no 1098 0.330421375160022 1686 1201127 SGTC_451 chloral hydrate 100 µM 0.436853966301382 0.333456880469269 no 1099 0.331108629219607 1601 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1899 st063254 59.6 µM 0.436435365778253 0.333610392619194 no 1100 0.331260442179851 1498 3093813 SGTC_3050 9093513 49.47 µM 0.434717066531659 0.334240831186772 no 1101 0.331883904491939 1555 25236664 SGTC_248 streptozotocin 5.23457 mM 0.434380293838965 0.33436444691761 no 1102 0.332006152689653 1661 5300 DNA alkylating agent. SGTC_2783 7738165 71.43 µM 0.434068023148346 0.334479084998472 no 1103 0.332119522662145 1479 17201110 SGTC_1906 st060206 94.7 µM 0.433252823058547 0.334778426836079 no 1104 0.332415553714402 1670 5133468 SGTC_186 3455-3465 67.277 µM 0.431235256650986 0.335519729404896 no 1105 0.333148660364398 1567 755278 SGTC_1456 k015-0012 13 µM 0.430888922203455 0.335647045547882 no 1106 0.333274569326123 1757 2989616 SGTC_2191 5911152 200 µM 0.429862874049743 0.336024342229333 no 1107 0.333647696638809 1597 2875902 SGTC_2845 9003024 42.97 µM 0.427059395861157 0.337056074285273 no 1108 0.334668033250011 1670 2990173 SGTC_2319 6033012 152.6 µM 0.426631788008159 0.337213549954119 no 1109 0.334823770364956 1508 847246 SGTC_62 0180-0423 3.232 µM 0.425517012047082 0.337624223928447 no 1110 0.335229911393069 1570 30102 YGL099W LSG1 SGTC_3136 9095672 49.47 µM 0.424941482722318 0.337836319777386 no 1111 0.335439666707335 1672 17217380 SGTC_967 1306-0166 352 µM 0.424840063980501 0.33787370026542 no 1112 0.335476634729991 1702 4437607 SGTC_1802 st050112 57.9 µM 0.424452879201491 0.338016421884649 no 1113 0.335617781630129 1590 4662563 SGTC_204 PMA1.184 62.41 µM 0.424407584600465 0.33803311961754 no 1114 0.335634295139548 1585 2252213 YGL008C PMA1 SGTC_2946 9065502 71.43 µM 0.423895331497358 0.338221982520598 no 1115 0.335821074508113 1525 16489101 SGTC_2634 4'-methoxyflavone 100 µM 0.42188079731975 0.338965116856206 no 1116 0.336556013462655 1583 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2833 9001315 45.46 µM 0.421133520132751 0.339240936884279 no 1117 0.336828792884081 1612 2989378 SGTC_3053 9095903 49.47 µM 0.420983029842843 0.339296493282113 no 1118 0.336883736912051 1659 17174018 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.420818531905302 0.339357224870177 no 1119 0.336943799116415 1556 115019 SGTC_308 4092-1169 104 µM 0.420590171581413 0.339441540960533 no 1120 0.33702718592602 1604 2268590 YDL196W YDL196W SGTC_896 0964-0007 44.5 µM 0.419495907786978 0.339845680789103 no 1121 0.337426872402271 1645 6756758 SGTC_2884 9058502 51.95 µM 0.417901444705357 0.340434886671604 no 1122 0.338009588104585 1556 6471554 SGTC_1824 st053723 68.6 µM 0.417682630512279 0.340515776062261 no 1123 0.338089586718468 1541 675225 SGTC_36 0335-0881 14.2 µM 0.416255377283455 0.341043570884392 no 1124 0.338611570688511 1622 23828853 SGTC_244 nsc-207895 1.295 µM 0.416168169884316 0.341075830070193 no 1125 0.338643474788445 1529 42640 SGTC_864 0469-0573 172 µM 0.415155844419922 0.341450387791398 no 1126 0.339013910304056 1581 689425 SGTC_1552 6-methylflavone 10.6 µM 0.415069030337846 0.341482516047875 no 1127 0.339045685028442 1684 689013 SGTC_932 2857-0803 154 µM 0.414642864144513 0.34164024878467 no 1128 0.339201682239216 1716 674898 SGTC_2013 4024628 200 µM 0.41332612220433 0.342127776270238 no 1129 0.339683846846189 1642 5230760 SGTC_2378 9074213 121.43 µM 0.413209748573285 0.342170876615937 no 1130 0.339726473180787 1578 657714 SGTC_3158 9100007 49.47 µM 0.413166998591978 0.342186710091761 no 1131 0.339742132526498 1569 19297233 SGTC_2097 5376186 200 µM 0.41316062342092 0.342189071312282 no 1132 0.339744467779466 1696 742755 SGTC_17 0960-0276 49.807 µM 0.411694374199157 0.342732300910175 no 1133 0.340281724497951 1619 6821114 SGTC_624 k048-0052 28 µM 0.41133899310661 0.342864014819517 no 1134 0.34041199058549 1605 6835531 SGTC_104 0074-0074 590.992 µM 0.410933995223442 0.343014141349393 no 1135 0.340560467084968 1638 3943124 SGTC_1947 st076332 61.6 µM 0.409517667892745 0.343539347030252 no 1136 0.341079901831339 1641 24208416 SGTC_1360 1598-0022 39.8 µM 0.409444472711527 0.343566497652761 no 1137 0.341106754190501 1705 761525 SGTC_2878 9043973 25.97 µM 0.409278591388634 0.343628031755636 no 1138 0.341167612334284 1697 6465167 SGTC_155 k072-0202 43.6 µM 0.408884188417629 0.343774353187086 no 1139 0.341312326543314 1616 5857737 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.408383219302697 0.343960243842341 no 1140 0.341496175615005 1725 94937 An inhibitor of serotonin biosynthesis. SGTC_2598 perillyl alcohol 100 µM 0.406509597458508 0.344655807958484 no 1141 0.342184103289875 1663 10819 An apoptosis inducer. SGTC_1504 k297-0033 30 µM 0.405984439770996 0.344850862097541 no 1142 0.342377016753199 1557 4388117 SGTC_985 1493-0307 8.71 µM 0.404576896373392 0.345373855342429 no 1143 0.342894271958764 1740 3278274 SGTC_3198 9112019 49.47 µM 0.403418195573156 0.345804609213559 no 1144 0.343320301661275 1646 45595555 SGTC_9 0092-0002 10.449 µM 0.40085527378331 0.346758099149036 no 1145 0.344263340503169 1623 759368 SGTC_1628 st004252 77.7 µM 0.399729462260683 0.3471772449572 no 1146 0.344677894750658 1734 692968 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.399609214086423 0.347222025074949 no 1147 0.344722184417794 1594 91467 include heat shock SGTC_895 0964-0006 13.7 µM 0.399504461295791 0.347261036489255 no 1148 0.344760768577906 1665 6738897 SGTC_3260 9137109 49.47 µM 0.396608070699895 0.348340332831242 no 1149 0.345828250057761 1725 17478346 SGTC_2427 5545055 42.75 µM 0.395904242009326 0.348602789970336 no 1150 0.346087835775774 1672 5372858 SGTC_1298 1079-1278 263 µM 0.395558950574453 0.348731575372613 no 1151 0.346215212434476 1635 2840950 SGTC_2658 polymyxin b sulfate 77.05 µM 0.395462529544824 0.348767541212369 no 1152 0.346250784883031 1623 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2272 7805186 180 µM 0.394963451925061 0.34895372299974 no 1153 0.346434930425809 1691 2956062 YPR165W RHO1 SGTC_2224 6650123 117.647 µM 0.394896602411068 0.348978664092047 no 1154 0.34645959876573 1644 2908370 SGTC_1125 tnp00248 1.32998 µM 0.393621568244114 0.349454495330158 no 1155 0.346930227508481 1822 24207736 SGTC_1648 st011736 69.8 µM 0.390835568002601 0.350495028155376 no 1156 0.347959391208142 1709 2855514 SGTC_261 5-fluorouridine 15.376 µM 0.38945449039498 0.351011258459492 no 1157 0.348469984913107 1717 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2639 lactacystin 53 µM 0.388171638675552 0.351491019587616 no 1158 0.34894450995578 1735 3870 A proteasome inhibitor. SGTC_2723 salbutamol 83.58 µM 0.386666889621711 0.352054067520947 no 1159 0.349501415677703 1716 9884233 β2-adrenoceptor agonist SGTC_1837 st055472 66.5 µM 0.386043108406315 0.352287569582508 no 1160 0.349732371408574 1702 676091 SGTC_527 4476-4215 268 µM 0.385947279669197 0.352323446404101 no 1161 0.349767857042324 1662 4418754 SGTC_1630 st005209 31.3 µM 0.385829096108659 0.352367694341245 no 1162 0.349811622533453 1738 3367314 SGTC_1268 0828-0275 2.46 µM 0.384012235584528 0.353048178266559 no 1163 0.350484689408961 1705 745337 SGTC_797 k781-0471 270 µM 0.383825486099879 0.353118149796058 no 1164 0.350553898531611 1713 23738129 SGTC_3173 9105693 49.47 µM 0.383500289920692 0.353240006558578 no 1165 0.350674427663932 1714 17096658 SGTC_2228 7354201 200 µM 0.380953684764976 0.354194784040017 no 1166 0.351618807959802 1744 753451 SGTC_2611 pyromycin 23.93 µM 0.38058739594971 0.354332189255621 no 1167 0.351754717632642 1610 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2359 9039622 200 µM 0.380463733680975 0.354378582726428 no 1168 0.351800606191517 1720 6463596 SGTC_2540 epiandrosterone 100 µM 0.37614739414918 0.355999261976342 no 1169 0.353403660839687 1673 441302 A steroid. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.37540808078771 0.356277118109454 no 1170 0.353678498022213 1647 75037 A free radical scavenger. SGTC_1426 4048-4480 71.7 µM 0.372811171516141 0.357253718533082 no 1171 0.3546444938297 1736 14224343 SGTC_1686 st019653 115.5 µM 0.37197688623096 0.357567660936992 no 1172 0.354955029320791 1765 97252 SGTC_1669 st015249 58.4 µM 0.369754132077412 0.358404555652966 no 1173 0.355782847046371 1794 722793 SGTC_1719 st032227 49.2 µM 0.367563464420567 0.359230035418116 no 1174 0.356599380825124 1610 3125804 SGTC_10 0279-0212 42.575 µM 0.367459709859954 0.359269148189884 no 1175 0.356638069897744 1647 39851 YBR002C RER2 SGTC_2113 5491891 107.031 µM 0.366871732819828 0.359490828097356 no 1176 0.356857348706751 1606 789979 SGTC_38 0929-0051 58.268 µM 0.365667523472666 0.359944988305847 no 1177 0.357306591364134 1829 1379719 SGTC_1721 st082152 9.2685 µM 0.363592758951725 0.360727936750574 no 1178 0.358081067373459 1630 5296051 SGTC_2122 5258151 111.688 µM 0.36319944149874 0.360876427887817 no 1179 0.358227952400617 1645 2173356 SGTC_816 0325-0417 81.3 µM 0.362659918515004 0.361080150856208 no 1180 0.358429472246175 1653 68101 SGTC_2130 NSC 7 2.4545 µM 0.361644572942329 0.361463650469002 no 1181 0.358808825790219 1795 21448 SGTC_2690 usnic acid 100 µM 0.360653789387225 0.361838007147748 no 1182 0.359179136780021 1813 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1668 st014914 51.6 µM 0.360400215722512 0.361933838438962 no 1183 0.359273932662645 1698 2839556 SGTC_1922 5578187 25 µM 0.359902265080926 0.362122050570191 no 1184 0.35946011154761 1791 1350412 SGTC_495 decylubiquinone 155 µM 0.359058940246203 0.36244088101461 no 1185 0.359775498562927 1665 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2895 9054447 58.44 µM 0.358097783847121 0.362804375644024 no 1186 0.360135068735957 1694 2697450 SGTC_150 3970-0969 77.2 µM 0.357791971831867 0.362920055012073 no 1187 0.360249499479436 1720 6615640 SGTC_729 4092-0585 94.1 µM 0.357648868107385 0.362974191088161 no 1188 0.360303051269807 1643 2169061 SGTC_278 4092-0821 23.9 µM 0.357318607425704 0.363099139009254 no 1189 0.360426650762249 1749 877900 SGTC_2719 novobiocin 32.65 µM 0.356882591887248 0.3632641196094 no 1190 0.360589851166918 1793 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.355164840052997 0.363914333249266 no 1191 0.361233051707294 1683 4620898 SGTC_24 0417-1663 219 µM 0.354891166273575 0.364017962128526 no 1192 0.361335563294036 1689 4329390 SGTC_1145 3546-0597 10.2 µM 0.354726430284546 0.364080345592176 no 1193 0.361397274217085 1688 875334 SGTC_1023 4482-3888 16 µM 0.354239507582806 0.364264758195752 no 1194 0.361579698966804 1795 3303168 SGTC_2254 7938975 95.19 µM 0.353288813338354 0.364624905899076 no 1195 0.361935965590882 1787 2969277 SGTC_1718 roemerine 11.9335 µM 0.351321960786386 0.365370379884537 no 1196 0.362673410685485 1694 235224 An aporphine alkaloid with mutagenic activity. SGTC_1842 st055362 61.2 µM 0.35099370080889 0.365494846201548 no 1197 0.362796537084322 1757 676032 SGTC_1955 wogonin 32.4 µM 0.350229935864818 0.365784497713405 no 1198 0.363083071083216 1804 5281703 A flavanone. SGTC_1109 tnp00067 928.257 nM 0.349567703304461 0.366035705866212 no 1199 0.363331576253841 1673 676295 SGTC_561 1550-0330 72.9 µM 0.34951441125077 0.366055923919102 no 1200 0.363351576792875 1673 6812934 SGTC_187 1488-2104 32.728 µM 0.349222403585469 0.366166713010213 no 1201 0.363461174052916 1771 2852859 SGTC_2864 9034755 47.6 µM 0.34887906751647 0.366296990612461 no 1202 0.363590050351034 1776 4930451 SGTC_1798 st045719 60.953 µM 0.348008466371183 0.366627406053794 no 1203 0.363916912609531 1788 3980186 SGTC_92 0063-0024 660.874 µM 0.34766623507997 0.366757318681436 no 1204 0.364045428537511 1768 3594437 SGTC_1137 ixabepilone 100 µM 0.345837247877803 0.367451869367309 no 1205 0.364732515323479 1644 154225 A novel microtubule stabilizer. SGTC_2970 9090938 41.86 µM 0.344662892200163 0.367898055169824 no 1206 0.365173909158774 1867 17217104 SGTC_2549 cedrol 20.94 µM 0.344627563276819 0.367911480839949 no 1207 0.365187190674678 1784 6708665 A sedative which affects the nervous system. SGTC_438 sphingosine 6.67 µM 0.344003489500967 0.368148667461705 no 1208 0.365421830916094 1541 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_782 0083-0095 30.5 µM 0.343420699366739 0.368370209140621 no 1209 0.365640994760559 1697 3591729 An indicator and reagent. SGTC_302 1094-0063 18.9 µM 0.342553873799532 0.368699804918552 no 1210 0.365967053994838 1714 5440289 SGTC_1647 st011722 22.4 µM 0.34212297255481 0.368863683800756 no 1211 0.366129174934081 1733 2854783 SGTC_393 acivicin 6.25 µM 0.341279451241242 0.369184557936337 no 1212 0.366446607927332 1712 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2352 9027995 87.8 µM 0.340681221761474 0.369412178729248 no 1213 0.36667178837816 1769 2997347 SGTC_1433 4060-0023 7.6 µM 0.340467627365402 0.369493460520297 no 1214 0.36675219888638 1766 3840627 SGTC_3252 9135871 49.47 µM 0.339823602505472 0.369738574784656 no 1215 0.366994686167392 1770 17682838 SGTC_1774 st048371 48.465 µM 0.338842279687442 0.370112165575308 no 1216 0.367364274393923 1670 4242727 SGTC_2479 5617353 43.85 µM 0.33829076382131 0.370322182166202 no 1217 0.367572041634636 1772 2731746 SGTC_2511 berberine 10.47 µM 0.337890831118989 0.37047450025422 no 1218 0.367722728667511 1709 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1857 st056007 79.3 µM 0.337637348069474 0.37057105214695 no 1219 0.367818246802945 1773 619834 SGTC_1370 2001-0092 44.6 µM 0.337620619388692 0.370577424401444 no 1220 0.367824550835142 1852 790957 SGTC_262 fenpropimorph 62.5 µM 0.337387685370314 0.370666156834681 no 1221 0.367912333335559 1687 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1911 st060208 74.3 µM 0.336674739984926 0.370937784541823 no 1222 0.368181053685622 1806 688783 SGTC_1888 azatryptophan 97.5 µM 0.336543626034793 0.370987745138425 no 1223 0.36823047962567 1699 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1202 1988-0068 29.6 µM 0.336223099698508 0.371109889939508 no 1224 0.368351317410518 1640 2850480 SGTC_2618 avocadyne 43.43 µM 0.335803640949994 0.371269755094321 no 1225 0.368509472187385 1792 3015189 SGTC_1503 4585-0012 61.3 µM 0.33571009494406 0.371305410609551 no 1226 0.368544746269856 1792 2922052 SGTC_1176 0848-0131 83.3 µM 0.335078597012163 0.371546137999683 no 1227 0.368782898819985 1876 6769040 SGTC_2862 9027634 71.43 µM 0.334914023232119 0.371608881880634 no 1228 0.368844971700226 1655 5012562 SGTC_400 oxethazaine 37.5 µM 0.332972412075639 0.372349379733249 no 1229 0.369577554001558 1720 4621 A local anesthetic. SGTC_702 1488-0190 94 µM 0.332639990275616 0.372476207237952 no 1230 0.369703026440379 1865 949357 SGTC_2872 9044037 25.97 µM 0.332232289594491 0.372631774462067 no 1231 0.369856931797223 1813 6465195 SGTC_3281 9140613 49.47 µM 0.331777521415886 0.372805325847939 no 1232 0.370028629540091 1631 16013766 SGTC_1485 3909-9022 254 µM 0.33024346176338 0.37339095325771 no 1233 0.370608004736189 1760 714516 SGTC_2 0422-0095 29 µM 0.330050346206654 0.373464695898388 no 1234 0.370680960386427 1718 6790840 SGTC_212 3807-4682 38.772 µM 0.329573366545086 0.373646854053672 no 1235 0.370861174809244 1823 3125501 YBL034C STU1 SGTC_1199 1638-0010 4.46 µM 0.329128770787611 0.373816670244037 no 1236 0.371029179324469 1698 3111136 SGTC_66 0109-0187 42.4 µM 0.328244622974428 0.374154448920733 no 1237 0.371363355465904 1631 759417 SGTC_2077 5212015 200 µM 0.327624775809252 0.374391312162775 no 1238 0.371597693299817 1681 780900 SGTC_349 k015-0014 24 µM 0.32474666446504 0.375491749602627 no 1239 0.372686406982928 1691 2196908 SGTC_749 1000-0129 128 µM 0.323545426042591 0.37595133998432 no 1240 0.37314110541201 1869 708470 SGTC_3212 9128307 49.47 µM 0.323506158050352 0.37596636678014 no 1241 0.373155972304169 1576 27243542 SGTC_836 0330-0104 1.35 µM 0.322781883276709 0.376243560800277 no 1242 0.373430217137625 1767 46494820 SGTC_2733 amorolfine 100 µM 0.3216035370941 0.376694673149369 no 1243 0.373876531939983 1850 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2269 7935389 174.42 µM 0.31891469791294 0.37772468508684 no 1244 0.3748955992577 1685 97605 SGTC_2144 5628481 200 µM 0.317929408675259 0.378102337434793 no 1245 0.375269242098052 1752 2818399 SGTC_2275 7947463 200 µM 0.317525129803734 0.378257327555783 no 1246 0.375422587218101 1861 1225414 SGTC_2659 sanguinarine 24.21 µM 0.316848884042024 0.378516626570458 no 1247 0.375679134815878 1746 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2214 7179297 48.276 µM 0.316438266440056 0.378674100084971 no 1248 0.375834937795228 1819 769744 SGTC_679 0422-0091 41.4 µM 0.316242843943653 0.378749052481549 no 1249 0.375909095179922 1687 627384 YHR062C RPP1 SGTC_268 camptothecin 39.6153 µM 0.315497513917191 0.379034958403224 no 1250 0.376191969180205 1746 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_637 1181-0519 7.26 µM 0.315455801346827 0.379050961152702 no 1251 0.376207802257271 1740 6252091 YGR060W ERG25 SGTC_2956 9076196 2.52 µM 0.314505480286001 0.379415601600564 no 1252 0.376568577409445 1809 16423868 SGTC_1 0258-0098 57.368 µM 0.313960162312861 0.379624889870065 no 1253 0.37677564792376 1758 6790032 YDR047W HEM12 SGTC_2138 5575593 77.673 µM 0.313701744130187 0.379724080830234 no 1254 0.376873787986161 1716 762213 SGTC_556 4058-0063 51.5 µM 0.311131833333353 0.380710942402505 no 1255 0.37785020089708 1768 6615692 SGTC_1262 0737-0114 49.6 µM 0.310427296839569 0.380981624671392 no 1256 0.378118019423264 1906 765919 SGTC_221 trifluoperazine 10.304 µM 0.309739888938041 0.381245782299457 no 1257 0.378379383245308 1764 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3216 9129716 49.47 µM 0.30883335101611 0.381594231974128 no 1258 0.378724148992184 1710 8056934 SGTC_783 0848-0141 92.7 µM 0.308821388802636 0.381598830581073 no 1259 0.378728698991575 1747 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_574 1315-0397 40 µM 0.308502338944942 0.381721488368757 no 1260 0.378850060379832 1774 6794277 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.30833597935643 0.381785449539309 no 1261 0.378913345606648 1839 279621 SGTC_1068 loratadine 26.9 µM 0.30763949225671 0.382053266723306 no 1262 0.379178333064834 1744 3957 A H1 histamine antagonist. SGTC_365 0121-0052 13.6 µM 0.307175753039973 0.382231617680087 no 1263 0.379354800101315 1810 3101739 SGTC_3040 9091894 49.47 µM 0.305840220774992 0.382745393824681 no 1264 0.379863151540686 1854 25236966 SGTC_440 fluspirilene 35.1 µM 0.303410261097559 0.383680722507629 no 1265 0.380788613397381 1849 3396 An atypical antipsychotic. SGTC_2728 chlorpromazine 9.18 µM 0.300925483403302 0.384637852796445 no 1266 0.381735658763376 1813 2726 A thorazine and dopamine antagonist. SGTC_541 4513-1321 94 µM 0.297747892881723 0.385862877493286 no 1267 0.38294779352306 1739 747515 SGTC_1161 k007-0610 110 µM 0.297117860379962 0.38610590332925 no 1268 0.383188264571555 1857 5843850 SGTC_1853 st056710 91.2 µM 0.296957995018851 0.386167576170941 no 1269 0.383249289208592 1941 269167 SGTC_3254 9136651 49.47 µM 0.296862523552745 0.38620440851473 no 1270 0.383285734454932 1761 16454030 SGTC_1263 0774-1208 64.8 µM 0.295908686248052 0.386572449729086 no 1271 0.383649908658932 1926 906585 SGTC_2858 9025781 8.96 µM 0.295849736260783 0.38659519912445 no 1272 0.383672419085927 1895 4894980 YPL153C RAD53 SGTC_2811 7967822 32.47 µM 0.295581498909454 0.386698719547326 no 1273 0.383774852178358 1852 2232244 SGTC_216 k038-0035 28.382 µM 0.295567811733385 0.386704002034107 no 1274 0.383780079184211 1875 4444231 YPR107C YTH1 SGTC_3060 1327-0027 12.5 µM 0.294930647923168 0.386949934955381 no 1275 0.384023429535275 1895 16000455 YPR107C YTH1 SGTC_596 1155-0152 116 µM 0.293922792454526 0.387339040354862 no 1276 0.384408450557287 1756 280313 SGTC_713 1488-1073 324 µM 0.293615417703011 0.387457731876413 no 1277 0.384525896599368 1910 3312542 SGTC_1130 3454-2858 15.9 µM 0.290865913031463 0.388519908721524 no 1278 0.38557693607523 1717 715628 YIL048W NEO1 SGTC_1924 st058459 75.1 µM 0.289215603479923 0.389157850350806 no 1279 0.386208195997194 1825 688683 SGTC_231 b-estradiol 524 µM 0.288714052304869 0.389351788659548 no 1280 0.386400104127108 1758 450 A steroid. SGTC_2742 clothiapine 36.27 µM 0.288478342919326 0.389442941583795 no 1281 0.38649030302523 1912 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1392 3455-1037 33.9 µM 0.287906118271947 0.389664256120637 no 1282 0.386709301710803 1885 981132 SGTC_1090 efavirenz 20.7 µM 0.286725278954686 0.390121072495613 no 1283 0.387161340055026 1852 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_426 0988-0037 14.6 µM 0.286166834556099 0.390337163720271 no 1284 0.387375172093905 1973 5383008 SGTC_386 1509-0011 3.07 µM 0.283857927879647 0.391230958936583 no 1285 0.388259629737652 1788 3107280 SGTC_2081 5214970 32.255 µM 0.282966406535864 0.39157622763804 no 1286 0.388601294348728 1911 2063512 SGTC_3298 9116858 71.43 µM 0.282820261138679 0.391632835036409 no 1287 0.388657311008594 1893 2506942 SGTC_2504 purpurogallin 52.29 µM 0.282026473623762 0.391940337702073 no 1288 0.388961605445581 1777 5281571 An antioxidant. SGTC_1133 3473-0247 50 µM 0.281447756460438 0.392164567553632 no 1289 0.389183496700578 1694 711311 SGTC_1245 0418-0076 17.2 µM 0.280960392291562 0.392353429541519 no 1290 0.389370389505284 1833 6790114 SGTC_763 3453-1109 128 µM 0.278512977894786 0.393302227210832 no 1291 0.390309302040625 1943 1560353 SGTC_1704 st028805 70.8 µM 0.27819643865605 0.393424987504878 no 1292 0.390430784271249 1787 2876101 SGTC_2259 7964009 200 µM 0.277827193211809 0.393568201715542 no 1293 0.390572507740614 1863 313134 SGTC_299 1273-0059 1.44 µM 0.277153038544077 0.393829714053738 no 1294 0.390831298699961 1902 2848077 SGTC_1616 st002734 56.1 µM 0.276695671942168 0.394007159083221 no 1295 0.3910068977324 1854 4026101 SGTC_2465 5809242 33.21 µM 0.276435229812733 0.394108212941717 no 1296 0.391106900506291 1866 2731748 SGTC_2945 9067681 61.76 µM 0.275775479020446 0.394364233996318 no 1297 0.391360259275145 1860 16456930 SGTC_2457 5731572 11.68 µM 0.275188795466826 0.394591939126456 no 1298 0.391585597350832 1936 2865357 SGTC_504 lovastatin 124 µM 0.274375193773462 0.394907775904679 no 1299 0.391898152144976 1763 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2642 cholecalciferol 100 µM 0.274310839842086 0.394932760782453 no 1300 0.391922877455759 1893 9821465 A vitamin D precursor, similar to steriods. SGTC_647 0140-0236 81 µM 0.272830366564336 0.395507661303355 no 1301 0.392491807819321 1856 990837 SGTC_1059 3448-6867 171 µM 0.271879593579163 0.39587698750987 no 1302 0.392857301188297 1987 3934407 SGTC_1673 st016611 27.3 µM 0.26993941281683 0.39663093728411 no 1303 0.393603432619689 1909 5226799 SGTC_120 rhodamine 6G 52.259 µM 0.269829295411726 0.396673740275166 no 1304 0.393645791996113 1819 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_716 1683-5115 658 µM 0.269084845796565 0.39696314288209 no 1305 0.393932195899085 1953 723597 SGTC_245 methotrexate 289.6 µM 0.269037317564249 0.39698162127212 no 1306 0.393950482862658 1880 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1094 duloxetine 25.4 µM 0.268989900833432 0.397000056542218 no 1307 0.393968727157923 1840 60834 A selective serotonin reuptake inhibitor. SGTC_2297 7971671 152.32 µM 0.268698228867907 0.397113461480583 no 1308 0.394080957418961 1909 909016 SGTC_2332 7982454 138.89 µM 0.26835409627632 0.397247274815013 no 1309 0.394213384920303 1860 2981748 SGTC_2322 7413319 38.22 µM 0.268149749191371 0.397326739345683 no 1310 0.394292026602213 1832 1840400 SGTC_1550 gossypolone 36.6 µM 0.265344059006351 0.398418218798377 no 1311 0.395372213166241 1903 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_531 3788-1495 174 µM 0.26422552555184 0.398853576788556 no 1312 0.395803071617087 1800 2896655 SGTC_2232 chlorophetanol 41.5365 µM 0.263544648975294 0.399118650697054 no 1313 0.396065407277486 1920 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1229 0139-0193 12.2 µM 0.262293193176486 0.399605979613939 no 1314 0.396547704717021 1963 3090752 SGTC_1088 bifonazole 369 nM 0.261396934833605 0.399955087416065 no 1315 0.39689321027069 1892 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2907 7721985 69.9 µM 0.260874885767073 0.400158471245513 no 1316 0.397094496325591 1797 3267881 SGTC_82 0054-0107 293.755 µM 0.260341565077722 0.400366274324464 no 1317 0.397300156680186 1973 3104697 SGTC_2492 derrusnin 100 µM 0.258273474563705 0.401172351398617 no 1318 0.3980979280953 1837 1715307 Part of coumarin class of compounds. SGTC_1351 1496-0003 46.5 µM 0.257128769697309 0.401618702758645 no 1319 0.398539684498339 1938 3891978 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.256829214890948 0.401735528489878 no 1320 0.398655308059962 1947 688662 SGTC_1815 st051655 58.2 µM 0.256792464614981 0.401749861623588 no 1321 0.398669493715745 1970 5984156 SGTC_2605 digitonin 300 nM 0.256639196099103 0.401809639963585 no 1322 0.398728657011532 2021 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2710 st078562 53.7235 µM 0.25554046851094 0.402238236850106 no 1323 0.399152845739743 1860 17250908 SGTC_790 1575-0012 79.1 µM 0.255473785516583 0.402264252659087 no 1324 0.39917859406236 1962 378741 YLR208W SEC13 SGTC_1061 3448-9325 110 µM 0.254841537048093 0.40251094057458 no 1325 0.399422746115155 1978 723482 SGTC_2456 5770359 74.46 µM 0.253738222485378 0.402941519917401 no 1326 0.399848901449659 1949 3118787 SGTC_1929 genistein trimethyl ether 50.5 µM 0.252577604273076 0.403394589628858 no 1327 0.40029731909109 2027 136420 SGTC_2924 9010168 62.78 µM 0.251463863694022 0.403829481706066 no 1328 0.40072774866246 1854 2993929 SGTC_1612 st002233 45.4 µM 0.249785588241178 0.404485037124789 no 1329 0.401376582729493 1946 1035021 SGTC_875 0709-0210 25.7 µM 0.249716129647655 0.404512174314763 no 1330 0.401403441825081 2018 6251364 SGTC_891 0929-0073 133 µM 0.24836875304474 0.405038679604956 no 1331 0.401924553856842 1943 5603632 SGTC_2709 st078560 56 µM 0.248314355200676 0.405059939901691 no 1332 0.401945596462532 1970 17250903 SGTC_2062 5245942 200 µM 0.24807367326269 0.405154008929172 no 1333 0.402038702369761 1939 1376160 SGTC_444 curcumin 90.4 µM 0.248004717190947 0.405180960987933 no 1334 0.402065378506372 1915 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3250 9135583 49.47 µM 0.247843025632453 0.40524416125249 no 1335 0.402127931800738 1979 7699353 SGTC_1120 ficusin 1.78878 µM 0.246125031168992 0.405915824821027 no 1336 0.402792723445921 1943 6199 A DNA cross-linker. SGTC_2006 4011487 200 µM 0.245193949935776 0.406279954305069 no 1337 0.403153130344643 1955 45595294 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.244583198899614 0.40651885233879 no 1338 0.403389587174087 1848 5355888 SGTC_3059 1327-0034 3 µM 0.244257383386588 0.406646310791601 no 1339 0.403515743539575 1818 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2875 9039966 71.43 µM 0.243446314869114 0.406963642289457 no 1340 0.403829834339102 1977 6463691 SGTC_3151 9099821 49.47 µM 0.243434147803631 0.406968403133519 no 1341 0.403834546575641 1817 17174189 SGTC_1007 4101-0031 70 µM 0.242363416376638 0.407387422776971 no 1342 0.404249289464463 1993 1146276 SGTC_822 1487-0950 154 µM 0.240336125039641 0.408181072192255 no 1343 0.405034845909545 2003 1958375 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.239683532599566 0.408436631151804 no 1344 0.40528780098128 1840 229346 A bile salt which induces apoptosis. SGTC_363 0455-0021 3.06 µM 0.239618840594455 0.408461967037181 no 1345 0.405312878775102 1869 4597466 SGTC_2784 7567673 72.73 µM 0.239182137385186 0.408633006868424 no 1346 0.40548217652046 1885 3471247 SGTC_566 0958-0068 16.5 µM 0.238571289118777 0.408872281804201 no 1347 0.405719015145431 1941 6815365 SGTC_2475 5812728 15.03 µM 0.237965419072787 0.409109640277292 no 1348 0.405953957707043 1916 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1870 st057514 26.5 µM 0.237445544601646 0.40931333529675 no 1349 0.406155580156999 1862 5393161 SGTC_693 4161-2696 114 µM 0.236038748102114 0.409864662996951 no 1350 0.406701301442542 1969 805759 SGTC_2036 5160441 105 µM 0.235644545234609 0.410019184283653 no 1351 0.406854252271206 1915 134534 YIL048W NEO1 SGTC_207 4185-0010 4.486 µM 0.234531854277011 0.410455416845795 no 1352 0.407286053271142 1993 3761753 SGTC_1665 st014639 11.4 µM 0.233688784526618 0.410786017728298 no 1353 0.407613297677979 1930 981133 YIL048W NEO1 SGTC_2774 tamoxifen 10.92 µM 0.232996333888928 0.411057602343285 no 1354 0.407882126284792 1928 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2089 5281248 129.67 µM 0.23205727606363 0.411425976341486 no 1355 0.408246763939481 1845 2737878 SGTC_1809 st050081 57.6 µM 0.230871950249211 0.411891067920242 no 1356 0.408707141272533 1985 5036894 SGTC_3160 9100216 49.47 µM 0.230380582102273 0.412083904567554 no 1357 0.40889802430727 2018 17191039 SGTC_520 3584-0023 682 µM 0.230060465407751 0.412209545278636 no 1358 0.409022392482029 1843 1340790 SGTC_192 3455-0609 60.9 µM 0.229993225886053 0.412235936865392 no 1359 0.409048516796953 1925 3769639 SGTC_22 0964-0034 14.468 µM 0.229553174142219 0.412408667455308 no 1360 0.409219498391598 1903 138402 SGTC_629 3448-6466 76.7 µM 0.22893705024674 0.412650538978667 no 1361 0.409458921631352 1915 573744 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.228538596051115 0.412806977659202 no 1362 0.409613777300188 1872 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2794 7785382 27.27 µM 0.228290990035468 0.412904198216795 no 1363 0.409710014275432 2064 2205081 SGTC_2799 7812892 81.82 µM 0.227179735209742 0.413340589405711 no 1364 0.410141992356957 1984 20205235 SGTC_101 0490-5701 117.494 µM 0.226931538013603 0.413438071409423 no 1365 0.410238488969952 2013 4661669 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.226854318730038 0.413468401166533 no 1366 0.41026851217184 1965 616764 SGTC_3187 9109394 49.47 µM 0.226327212778524 0.41367544866841 no 1367 0.410473467356352 1848 17098090 SGTC_1074 carmofur 3.8 µM 0.223694546073307 0.414709919786872 no 1368 0.411497495011812 1948 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1459 k035-0031 35.7 µM 0.22321526466436 0.414898310879399 no 1369 0.411683986076575 1826 3877128 YMR208W ERG12 SGTC_2380 9035439 200 µM 0.222940138328436 0.415006463604334 no 1370 0.411791048282453 1975 6462575 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.22290313102493 0.415021011742661 no 1371 0.411805449744383 1952 88881 An O-methylated flavonoid and antioxidant. SGTC_1976 st070609 63.5 µM 0.222103574848149 0.415335357957033 no 1372 0.412116627517044 1971 682556 SGTC_1039 k821-0043 94 µM 0.221893766997865 0.415417853083182 no 1373 0.412198291403124 2002 15992768 SGTC_3306 9127676 59.7925 µM 0.221735092786381 0.415480245260803 no 1374 0.412260054976367 1874 41905287 SGTC_1004 4084-0029 199 µM 0.220477763441301 0.415974714091115 no 1375 0.412749544255937 2032 716894 YLR208W SEC13 SGTC_965 1291-5240 308 µM 0.219072498330767 0.416527518909189 no 1376 0.413296786787529 1998 2834598 SGTC_2689 tacrolimus 100 µM 0.215136299134495 0.418076821226381 no 1377 0.414830526912289 1891 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3256 9138902 49.47 µM 0.214393650185286 0.418369273931253 no 1378 0.415120046484959 1979 17228773 SGTC_2842 9000675 19.48 µM 0.21287017385293 0.41896935497025 no 1379 0.415714113504699 1801 2989072 SGTC_1769 st044406 64.4 µM 0.212581226890551 0.41908318940559 no 1380 0.415826807766242 1892 670903 SGTC_2985 9022375 71.43 µM 0.211902791834431 0.419350494379406 no 1381 0.416091436243862 1941 4939335 SGTC_2531 methyl deoxycholate 70.07 µM 0.211721457632207 0.41942194678209 no 1382 0.416162173403246 1898 16667744 Haematoxylin. SGTC_1171 0368-0077 21.4 µM 0.21117245618517 0.419638289909429 no 1383 0.416376351441647 1908 3239779 SGTC_583 1488-1091 88.9 µM 0.211119025770506 0.419659346348817 no 1384 0.416397197197087 2081 4303273 SGTC_1247 0448-0043 5.84 µM 0.210718243188543 0.419817298441186 no 1385 0.416553569108255 1906 3089013 YGL099W LSG1 SGTC_1999 st074831 12.5 µM 0.210179223756359 0.420029751309803 no 1386 0.416763897218906 1912 17112523 SGTC_2922 7999257 32.47 µM 0.209200631755729 0.420415519891268 no 1387 0.417145809633163 1976 2988377 SGTC_2362 9071156 126 µM 0.207960124750088 0.420904647250096 no 1388 0.417630051239553 2007 653133 SGTC_726 3448-4391 34.2 µM 0.207601659326098 0.421046011627465 no 1389 0.417770004319217 1998 1356692 SGTC_114 0364-0001 490.298 µM 0.207098171861372 0.42124458406447 no 1390 0.417966594896562 1889 4003655 SGTC_1920 st075728 45.7 µM 0.206196790917695 0.421600133309732 no 1391 0.418318597232876 2069 3400306 SGTC_3293 9120939 62.045 µM 0.205816142539161 0.421750299079907 no 1392 0.418467265612714 1975 934087 SGTC_2969 9091408 28.7 µM 0.205795591608629 0.421758406745138 no 1393 0.418475292442555 1811 4286311 SGTC_1078 idebenone 36.1 µM 0.205254400796725 0.421971926956332 no 1394 0.41868668420626 1969 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_564 3555-0129 330 µM 0.204382711336727 0.422315889566506 no 1395 0.419027219697419 2059 563260 SGTC_3097 9117246 49.47 µM 0.203283852794044 0.422749575918225 no 1396 0.419456587820476 2023 16423892 SGTC_2537 larixol 68.93 µM 0.202589034084254 0.423023848286252 no 1397 0.419728130902911 1958 6708759 SGTC_2003 4023581 200 µM 0.200151629610333 0.423986282211301 no 1398 0.420680997808871 1917 16641307 SGTC_2506 ethyl hematommate 54.16 µM 0.200018990797517 0.42403866905808 no 1399 0.420732864362379 1868 3940691 An allergen. SGTC_2238 6671620 73.2395 µM 0.199065205278822 0.424415414376399 no 1400 0.421105869326785 2038 729941 SGTC_2315 7733312 200 µM 0.19903408697606 0.424427707272604 no 1401 0.421118040219345 1925 726316 SGTC_1248 0469-0687 58.6 µM 0.19799667724378 0.424837565013281 no 1402 0.421523831722448 1985 4017482 SGTC_1391 3442-0225 151 µM 0.197658280421183 0.424971275745597 no 1403 0.421656216523962 1952 5227075 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.197544474719434 0.425016245731586 no 1404 0.421700740638305 2013 165521 SGTC_1838 st055369 84.5 µM 0.197408969561834 0.425069791465822 no 1405 0.42175375551896 2058 676036 SGTC_1664 st014217 9.02 µM 0.196788942917121 0.425314816600109 no 1406 0.421996352100283 2092 3982782 SGTC_2904 7225135 42.03 µM 0.196338726649959 0.425492753331838 no 1407 0.42217252587233 2075 4446116 SGTC_1006 4099-6547 255 µM 0.195235817816448 0.425928714547515 no 1408 0.422604169992441 2023 3146833 SGTC_2564 betulinic acid 100 µM 0.193868917304005 0.426469152813465 no 1409 0.423139261158423 2128 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_677 0929-0063 136 µM 0.193440862439686 0.426638423439774 no 1410 0.42330685806426 2037 1539583 SGTC_3204 9114183 49.47 µM 0.193221100371401 0.42672533171706 no 1411 0.423392907200436 1888 17027248 SGTC_3012 9080433 71.4286 µM 0.192615913097696 0.42696468067294 no 1412 0.423629890726971 2088 17688859 SGTC_2296 7971656 126.45 µM 0.191198084481247 0.427525530927409 no 1413 0.424185202147776 1941 666570 SGTC_47 0149-0135 24.25 µM 0.188691162145543 0.428517551639879 no 1414 0.425167439373385 1857 5239155 SGTC_1332 1480-0653 17.5 µM 0.188591789477278 0.42855688400641 no 1415 0.425206384193364 2102 5749438 SGTC_176 1486-1328 72.834 µM 0.187733780563728 0.428896519145762 no 1416 0.425542674000203 1930 22310231 SGTC_2988 9073640 71.4286 µM 0.187089473109768 0.429151597108324 no 1417 0.425795240837619 2003 9102229 SGTC_893 0958-0369 48.9 µM 0.186551183412842 0.429364725884329 no 1418 0.426006272340056 2104 6819948 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.186019726224092 0.429575169619652 no 1419 0.426214646011792 1966 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_681 1642-0006 26.6 µM 0.185672803103015 0.429712553286311 no 1420 0.426350678704882 2070 4446530 SGTC_2775 cyproheptadine 69.59 µM 0.185207322535594 0.429896899792495 no 1421 0.426533212949994 2094 2913 A selective serotonin reuptake inhibitor. SGTC_3120 9124077 49.47 µM 0.185043137111753 0.429961926583381 no 1422 0.426597600623697 2102 18774327 YGL155W CDC43 SGTC_736 0958-0254 92.6 µM 0.18429901907702 0.430256663552195 no 1423 0.426889441705015 2029 6812352 SGTC_2545 solidagenone 89.61 µM 0.184206523967589 0.430293302566597 no 1424 0.426925720836896 2015 6708572 An anti ulcer agent SGTC_107 0358-0022 2.6945 µM 0.183276786233798 0.430661622071125 no 1425 0.427290423891625 2070 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1561 5-methoxyflavone 52.9 µM 0.182453555594298 0.430987798709175 no 1426 0.427613399888687 2088 94525 SGTC_2139 5578692 56.4705 µM 0.182232109536359 0.431075547086765 no 1427 0.4277002875504 2115 650991 YMR113W FOL3 SGTC_3241 9133421 49.47 µM 0.182077463660562 0.431136827796291 no 1428 0.427760967244513 2081 17018221 SGTC_1698 5-fluorocytosine 1.055 µM 0.181662816362279 0.431301146082561 no 1429 0.427923674297214 2102 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1037 k284-1091 78.7 µM 0.181605197026036 0.431323980672471 no 1430 0.427946285019259 2016 3334711 SGTC_2415 st077333 57.7 µM 0.181056361922767 0.431541495966151 no 1431 0.4281616682838 2157 2766255 SGTC_2421 5690543 90.72 µM 0.180972151307969 0.431574872303829 no 1432 0.428194717550081 1976 3397993 SGTC_2823 7987624 58.44 µM 0.180097073808381 0.431921732535355 no 1433 0.428538179906087 2000 2239440 SGTC_961 1252-1571 372 µM 0.179956654831994 0.43197739622375 no 1434 0.428593298508552 2084 6813498 SGTC_347 4534-1311 26.2 µM 0.178463865221721 0.432569238376689 no 1435 0.429179348495825 2025 2862016 SGTC_2836 9010338 19.48 µM 0.178195712247088 0.432675568312691 no 1436 0.429284638482957 1857 2994051 SGTC_834 0312-0008 75.7 µM 0.177742137923336 0.432855433942322 no 1437 0.429462745419086 1998 6385573 YIL048W NEO1 SGTC_2933 9026794 32.47 µM 0.17743240703531 0.432978266221525 no 1438 0.429584377001617 2019 17586027 SGTC_46 0329-0187a 2.197 µM 0.177054793285111 0.433128028070683 no 1439 0.429732675283323 2020 46494817 SGTC_1545 lovastatin 49.4 µM 0.176902720197078 0.433188343066299 no 1440 0.42979240095703 2000 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2276 7947513 42.08 µM 0.17680342852001 0.433227724819289 no 1441 0.429831397956751 1831 2105100 SGTC_3169 9102970 49.47 µM 0.175135472791995 0.433889379801001 no 1442 0.430486592871602 2086 17027839 SGTC_3245 9134821 49.47 µM 0.17505533676114 0.433921173336268 no 1443 0.430518076190365 1947 17014901 SGTC_2152 5568786 200 µM 0.17492045575933 0.433974687606838 no 1444 0.430571068351833 2052 5399883 SGTC_2968 9090663 33.37 µM 0.173621223499047 0.434490222079088 no 1445 0.431081575702169 1958 25236811 SGTC_2731 amoxapine 43.43 µM 0.173590376265175 0.434502463597924 no 1446 0.431093697909201 2138 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1780 st038448 24.544 µM 0.173083056159406 0.434703799195873 no 1447 0.43129307158355 2061 728868 YDL195W SEC31 SGTC_1189 1431-2119 7.28 µM 0.172415802558327 0.434968631946748 no 1448 0.431555324784073 2069 3107275 SGTC_3030 9087619 49.47 µM 0.171890442202355 0.43517716784815 no 1449 0.431761830383173 1993 25236973 SGTC_1046 2001-0062 216 µM 0.17109524318383 0.435492847462728 no 1450 0.432074438056591 1961 739778 SGTC_2445 5742597 35.57 µM 0.171020909133711 0.435522358839159 no 1451 0.432103662345033 1972 1774255 SGTC_148 3253-0744 288.01 µM 0.170659975795787 0.435665658159251 no 1452 0.432245567869415 2140 6893655 SGTC_64 000l-0018 272.079 µM 0.170065145468246 0.435901838701115 no 1453 0.432479452029995 1920 6811119 SGTC_3167 9103034 49.47 µM 0.167540686607249 0.436904441897718 no 1454 0.433472318320439 2091 5127859 SGTC_218 alverine citrate 93.75 µM 0.166871186304616 0.437170406029947 no 1455 0.433735702612759 2095 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1860 st056228 74.6 µM 0.164869482809168 0.437965767010017 no 1456 0.434523356422219 1986 688679 SGTC_2011 4012611 177 µM 0.164144853865206 0.438253754530555 no 1457 0.434808556186975 1989 2049887 SGTC_526 4469-0568 170 µM 0.163900733056224 0.43835078224228 no 1458 0.434904645004618 1917 2901964 SGTC_13 0199-0087 65 µM 0.161870628854014 0.439157805931157 no 1459 0.435703866264917 2118 4589825 SGTC_995 3931-2021 34.6 µM 0.160241766448977 0.439805507761123 no 1460 0.436345314796091 2018 730143 SGTC_1055 3448-0672 86 µM 0.160198846457344 0.439822576679087 no 1461 0.436362219026594 2044 748378 SGTC_1210 3013-0140 750 nM 0.159783913341534 0.439987597835986 no 1462 0.436525648277334 2152 905973 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.158895963120228 0.440340775461902 no 1463 0.436875420626236 2114 4000243 SGTC_3294 9122953 26.2835 µM 0.15726430387869 0.440989883077201 no 1464 0.437518275765489 2106 16459826 SGTC_2789 5281112 71.43 µM 0.155874544109673 0.441542883223453 no 1465 0.438065955439284 1976 765948 SGTC_2147 5545932 89.7195 µM 0.155562750117996 0.441666965049925 no 1466 0.438188844253973 2021 797404 SGTC_2283 7944793 200 µM 0.154347709499482 0.442150558255845 no 1467 0.438667790625174 2010 2970533 SGTC_2440 5628896 157.78 µM 0.153183032514116 0.442614187393544 no 1468 0.439126968921011 2025 5522048 SGTC_1234 0326-0494 15.5 µM 0.152599813385679 0.442846382095844 no 1469 0.439356936086183 2115 1547813 SGTC_3089 9117425 49.47 µM 0.151236667477106 0.443389162358519 no 1470 0.439894513239531 1974 9401657 SGTC_3083 9117465 49.47 µM 0.150637010240559 0.443627968825952 no 1471 0.440131032278338 1977 16420915 SGTC_1241 0364-0022 50.8 µM 0.149111416196061 0.444235610878549 no 1472 0.440732858889605 2073 4563895 SGTC_313 3474-0040 5.03 µM 0.148200958046883 0.444598307691003 no 1473 0.441092087877877 2047 1043375 YIL048W NEO1 SGTC_1374 2889-5571 141 µM 0.147593519868693 0.444840317057316 no 1474 0.44133178474248 2019 2853281 SGTC_1770 st043884 66.3 µM 0.14630015515817 0.445355674714111 no 1475 0.441842221688821 2150 670149 SGTC_3220 9131269 49.47 µM 0.146243121965909 0.445378402449129 no 1476 0.441864732533734 2162 17722206 SGTC_535 2293-4129 48.2 µM 0.14588852599697 0.44551971301687 no 1477 0.442004694802136 2140 396118 YIL048W NEO1 SGTC_3037 9091026 49.47 µM 0.144379603323113 0.446121113221067 no 1478 0.44260036111928 2151 25236398 YIL048W NEO1 SGTC_2644 guaiazulene 100 µM 0.144090876755761 0.446236203016343 no 1479 0.442714354418475 2145 3515 A coloring agent. SGTC_3024 9090631 49.47 µM 0.142378551512615 0.446918848700289 no 1480 0.443390501597365 2182 25236383 SGTC_1420 4'-methoxyflavone 42 µM 0.141478810535445 0.447277607920429 no 1481 0.443745849201596 2158 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3017 9080681 49.47 µM 0.140815060582638 0.44754229666671 no 1482 0.444008022497944 2034 16451914 SGTC_1644 st010134 20.9 µM 0.139915222309583 0.447901169478114 no 1483 0.444363486966991 2179 3818134 SGTC_2057 5236571 38.335 µM 0.13945095652161 0.448086344301326 no 1484 0.444546904101491 2142 54684039 YBR257W POP4 SGTC_1032 k061-1018 98.7 µM 0.138568709859011 0.448438264112271 no 1485 0.444895485317603 2182 4005393 SGTC_2586 curcumin 80 µM 0.13800557516329 0.448662914426357 no 1486 0.445118005684239 2131 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1724 st037281 8.293 µM 0.137891742388847 0.448708327533315 no 1487 0.445162988341921 2069 574124 YDL195W SEC31 SGTC_2601 securinine 100 µM 0.135307547429085 0.449739460912866 no 1488 0.446184358986191 2060 442872 A GABA receptor antagonist. SGTC_2587 piperic acid 92.2 µM 0.133888589815558 0.450305791554265 no 1489 0.446745336526955 2055 5370536 SGTC_926 2268-1401 59.4 µM 0.13382296221812 0.450331987126352 no 1490 0.446771284644941 2182 2931578 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.133807958723961 0.450337975873811 no 1491 0.446777216822143 2139 23847180 SGTC_1350 1495-0454 146 µM 0.13353379823971 0.450447410898808 no 1492 0.446885618238583 2153 1069057 SGTC_1895 st058434 18.3 µM 0.132186063233147 0.450985432967069 no 1493 0.447418562157762 2185 5393175 SGTC_2257 7960413 200 µM 0.131213890696398 0.451373584728246 no 1494 0.447803053888347 2098 2974689 YIL048W NEO1 SGTC_2274 7947094 46.08 µM 0.130836176884992 0.4515244041439 no 1495 0.447952451976741 2208 2971028 SGTC_3039 9090270 49.47 µM 0.129568335728438 0.452030698419413 no 1496 0.448453978223969 2204 17173750 SGTC_2666 tannic acid 100 µM 0.129478977547926 0.45206638528665 no 1497 0.448489329202419 2155 16134267 A thiamine antagonist. SGTC_1496 4469-0713 57.4 µM 0.129019903976489 0.45224973103693 no 1498 0.448670949681987 2164 746691 SGTC_997 3996-0078 137 µM 0.128909966893779 0.452293639448667 no 1499 0.448714445018068 2091 735687 SGTC_1865 st057639 52.2 µM 0.128780138872805 0.452345492969407 no 1500 0.448765810767727 2189 688818 SGTC_894 0960-0238 55.9 µM 0.128204212659705 0.452575528615243 no 1501 0.448993683181548 2162 6741907 YDL195W SEC31 SGTC_1401 3807-4679 7.6 µM 0.127514011336164 0.452851228830032 no 1502 0.449266792131403 2151 3291456 SGTC_2949 9072542 2.23 µM 0.127307691855971 0.45293364735503 no 1503 0.449348436312026 2080 16457352 SGTC_142 0335-0849 62.6745 µM 0.1270458192549 0.453038260627046 no 1504 0.449452066909689 2160 3889043 YPR107C YTH1 SGTC_2187 6125751 200 µM 0.126788846887143 0.453140919514825 no 1505 0.449553761694339 2120 874498 SGTC_2838 9002687 71.43 µM 0.126714303240126 0.453170699831775 no 1506 0.44958326237409 2000 6457060 SGTC_2805 7950783 58.44 µM 0.126080343289419 0.453423978564973 no 1507 0.44983416353789 2097 1178958 YDL195W SEC31 SGTC_3288 9119690 36.221 µM 0.125468652163997 0.453668378451645 no 1508 0.450076270421728 2061 17595618 YKL019W RAM2 SGTC_3304 9125678 46.087 µM 0.124777917760833 0.453944381002003 no 1509 0.450349684909222 2097 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2245 6637752 200 µM 0.122657251167074 0.454791891981745 no 1510 0.451189258397794 2181 681890 SGTC_828 2074-0507 139 µM 0.122059556315913 0.455030794293291 no 1511 0.451425925850823 2177 X828 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.120966876931445 0.455467586956912 no 1512 0.451858635434994 2115 2724278 An inhibitor of dopamine biosynthesis. SGTC_3152 9099253 49.47 µM 0.120101307156277 0.45581363202575 no 1513 0.452201448463471 2153 25236131 SGTC_86 0417-1630 471.922 µM 0.119821084128744 0.455925669238772 no 1514 0.452312439775957 2187 3634867 SGTC_1232 0279-0259 161 µM 0.119251349612672 0.456153468122737 no 1515 0.452538112875727 2070 1560000 SGTC_18 0111-0177 500 nM 0.118240282745251 0.456557761854919 no 1516 0.452938636398014 2159 721752 SGTC_480 am 92016 50 µM 0.117971218872679 0.456665359600386 no 1517 0.453045231309459 2052 2129 K+ channel blocker. SGTC_877 0771-0151 33.1 µM 0.117749045760427 0.456754208282496 no 1518 0.453133252080598 2107 6166523 SGTC_2338 7999974 200 µM 0.116927585659419 0.457082735034562 no 1519 0.453458718948039 2198 315925 SGTC_2076 5212012 200 µM 0.116050453089483 0.457433559268295 no 1520 0.453806278051793 2200 604802 SGTC_1490 4089-0339 670 nM 0.115827780629006 0.457522626232957 no 1521 0.453894516468344 2210 742542 SGTC_892 0929-0076 29 µM 0.114449675896465 0.458073902916175 no 1522 0.454440668496766 2059 5751038 SGTC_2847 9005661 71.43 µM 0.114383131426345 0.45810052443412 no 1523 0.454467042699353 2225 2991449 SGTC_2770 toltrazuril 17.5 µM 0.113207810699787 0.458570749471334 no 1524 0.454932901718098 2216 68591 Kills coccidiodes. SGTC_2757 clomiphene 4.22 µM 0.113113419339067 0.458608516309384 no 1525 0.454970318089819 2220 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1342 1486-1464 234 µM 0.112921500797341 0.458685305807345 no 1526 0.455046395091874 2192 3253938 SGTC_1931 st074438 57.1 µM 0.112158924245144 0.45899043937265 no 1527 0.455348698656356 2206 2787313 SGTC_1457 k015-0032 57.3 µM 0.111282344151842 0.459341219584743 no 1528 0.455696227881939 2204 4302660 SGTC_2920 7982904 15.77 µM 0.111177458190075 0.459383193824936 no 1529 0.455737813280204 2118 6456808 SGTC_662 k832-1615 104 µM 0.110769295949216 0.459546540293528 no 1530 0.455899646882213 2134 5878478 SGTC_665 3914-0008 307 µM 0.109192024804114 0.460177827911278 no 1531 0.456525092885833 2149 1069549 SGTC_1597 7-benzyloxygramine 47.5 µM 0.108457303149168 0.460471927564798 no 1532 0.456816473908676 2084 260807 SGTC_851 0394-0702 453 µM 0.107386860147266 0.460900450827906 no 1533 0.45724103915435 2225 762646 SGTC_2452 5863136 48.41 µM 0.105927466437688 0.461484753176023 no 1534 0.457819950798333 2197 2184096 SGTC_3274 9138298 49.47 µM 0.105211984509429 0.461771243525019 no 1535 0.458103800620585 2225 17015756 SGTC_40 0327-0103 19.753 µM 0.104631622264431 0.462003644381342 no 1536 0.458334060741283 2151 409036 SGTC_2291 7917025 104.35 µM 0.104627030917813 0.462005482996748 no 1537 0.458335882424979 2131 2964612 SGTC_1657 st012939 43.4 µM 0.104272536157291 0.462147443694471 no 1538 0.458476536027633 2205 24207257 SGTC_2703 st077852 53.4 µM 0.102523085690998 0.462848097550082 no 1539 0.459170744831462 2152 6281836 SGTC_2393 9031399 185.94 µM 0.101529170066452 0.463246211648314 no 1540 0.459565201414662 2193 1526623 YDL150W RPC53 SGTC_1440 4100-1550 40 µM 0.1015273110203 0.463246956326101 no 1541 0.459565939254137 2201 742806 SGTC_2354 9060492 162 µM 0.100628099136632 0.463607168518533 no 1542 0.459922845016904 2200 6471895 SGTC_866 0495-0101 262 µM 0.0980792506658146 0.464628364129932 no 1543 0.460934681823464 2015 635694 SGTC_1765 st044815 90.4 µM 0.0977386576534009 0.464764840447 no 1544 0.46106990906485 2093 645695 SGTC_528 3492-0019 172 µM 0.0957823189352481 0.465548829171392 no 1545 0.461846730116561 2235 2869262 SGTC_645 0845-0943 5.41 µM 0.0934691467800332 0.466475988649431 no 1546 0.462765429834312 2148 1885106 SGTC_279 1273-0055 2.93 µM 0.0932436122502318 0.466566396612746 no 1547 0.462855013861009 2233 2847562 SGTC_1296 1068-0102 11.9 µM 0.0918574375085029 0.467122097508361 no 1548 0.463405654190065 2212 767053 SGTC_817 1391-0715 46 µM 0.0904722829509543 0.467677453443372 no 1549 0.463955959304507 2140 1353946 SGTC_109 0132-0036 33.701 µM 0.0899246898227568 0.467897019709329 no 1550 0.464173530496248 2242 67274 A color developer. SGTC_118 0083-0097 135.343 µM 0.0898325453198873 0.467933967490581 no 1551 0.464210142655736 2244 5207356 SGTC_2749 bexarotene 57.39 µM 0.0894395443922957 0.468091554728935 no 1552 0.464366298751726 2148 82146 An retinoic acid receptor inhibitor. SGTC_576 1073-0113 22.7 µM 0.0877721068750731 0.468760226468467 no 1553 0.4650289038352 2281 5439563 SGTC_3051 9093778 49.47 µM 0.0877440708121968 0.468771470180913 no 1554 0.465040045619219 2262 17217378 SGTC_862 0452-0056 10.2 µM 0.0876595883409452 0.468805351572864 no 1555 0.465073619880264 2231 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2806 7952793 58.44 µM 0.087322268402502 0.468940634773244 no 1556 0.465207677000968 2194 2972490 SGTC_165 k038-0023 64.381 µM 0.0871986926261176 0.468990196117379 no 1557 0.465256789266575 2233 46368543 SGTC_2135 5326629 150.42 µM 0.0859494534837594 0.469491243257237 no 1558 0.465753299366763 2170 5020077 SGTC_522 1273-0010 11.6 µM 0.0853222031250554 0.469742840258484 no 1559 0.466002620176594 2172 5705015 SGTC_2340 7987427 183.45 µM 0.0852846703099494 0.469757895466516 no 1560 0.466017539224036 2211 2239331 SGTC_93 0109-0045 59.227 µM 0.0850749234750239 0.469842030165052 no 1561 0.466100913091588 2260 88733 SGTC_657 3534-0529 86.7 µM 0.0841221803183787 0.470224216154184 no 1562 0.466479644901389 2259 1049549 SGTC_3255 9139072 49.47 µM 0.0840181693373212 0.470265941069971 no 1563 0.466520992901271 2171 17646060 SGTC_982 1491-0518 27.5 µM 0.0834605149315566 0.470489654573862 no 1564 0.466742686167147 2179 3091256 SGTC_931 2812-0076 566 µM 0.08242268343782 0.470906024848741 no 1565 0.467155299321151 2260 3450959 SGTC_384 k007-0144 5.16 µM 0.0815512267655418 0.471255671368605 no 1566 0.467501793719606 2177 6824886 SGTC_428 3448-4153 16.5 µM 0.0813205771487148 0.471348216505554 no 1567 0.467593504993071 2209 3834874 SGTC_870 0573-2213 57.6 µM 0.0812551391506016 0.471374472926937 no 1568 0.467619524869118 2260 3916321 SGTC_2273 7815444 169.05 µM 0.081147772018159 0.471417553314308 no 1569 0.467662217175857 2281 2824616 SGTC_3068 9116768 49.47 µM 0.0809376482410359 0.471501865127088 no 1570 0.467745769600634 2190 41904888 SGTC_2358 9037157 4 µM 0.0804662671331388 0.471691010645962 no 1571 0.467933212069896 2192 2388925 SGTC_2874 9043904 71.43 µM 0.0803535697515941 0.471736232337961 no 1572 0.467978026705591 2134 4463428 SGTC_654 1124-0271 80.9 µM 0.0801449745310617 0.471819935588078 no 1573 0.468060976631409 2179 5403748 SGTC_873 0591-4978 488 µM 0.0788170159908614 0.472352836107454 no 1574 0.468589084674215 2257 3305145 SGTC_1354 1498-1681 81 µM 0.0782256935528807 0.472590145669175 no 1575 0.468824262068744 2172 5754243 SGTC_2007 4011539 71.82 µM 0.0775634905157281 0.472855912583008 no 1576 0.469087642600819 2231 45595301 SGTC_1302 1159-0335 255 µM 0.0773299784146623 0.472949632634736 no 1577 0.469180521488984 2225 649284 SGTC_323 4013-0906 34.3 µM 0.0752504567220123 0.47378431384465 no 1578 0.470007719732056 2273 2910086 SGTC_1066 ketoconazole 628 nM 0.074808301993212 0.473961801466068 no 1579 0.470183618147037 2246 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1852 st056254 31.4 µM 0.0743735202527955 0.474136334498252 no 1580 0.470356589106487 2194 442583 SGTC_116 0155-0182 31.788 µM 0.0740959460485922 0.474247762814494 no 1581 0.470467020490152 2121 771486 SGTC_1519 esterone 74 µM 0.0733079932616399 0.474564086485192 no 1582 0.470780515556909 2166 698 A steroid. SGTC_3141 9094609 49.47 µM 0.0731326786231116 0.474634468740113 no 1583 0.470850268746653 2143 25236309 YDL196W YDL196W SGTC_229 benomyl 22.8748 µM 0.0721268114498268 0.475038301934857 no 1584 0.471250494668532 2187 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3155 9099265 49.47 µM 0.071518840699179 0.475282401068236 no 1585 0.471492415121559 2233 25236499 SGTC_2261 9010538 184.68 µM 0.0701769142204503 0.475821214779778 no 1586 0.472026424399083 2126 6457250 SGTC_1840 st055363 71 µM 0.0700325684650168 0.475879175503708 no 1587 0.472083868690287 2134 676033 SGTC_2222 6885208 172.143 µM 0.069219646613474 0.476205606368045 no 1588 0.472407392439096 2280 609514 SGTC_2566 crystal violet carbinol 226 nM 0.0681004873980639 0.476655033716456 no 1589 0.472852821185906 2078 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1878 temozolomide 1 mM 0.0668892163663671 0.477141484394988 no 1590 0.473334948952628 2295 5394 DNA alkylating agent. SGTC_2346 9031566 143.75 µM 0.0661808127291996 0.477425997603647 no 1591 0.473616936251971 2245 4771086 SGTC_1203 3992-3522 103 µM 0.0653866892459593 0.477744951789996 no 1592 0.473933060921401 2296 5322312 SGTC_572 0960-0087 17.7 µM 0.0645728678646888 0.478071832289069 no 1593 0.474257043959249 2269 6796365 SGTC_616 4092-0450 108 µM 0.063991321260215 0.478305426065135 no 1594 0.474488568638328 2231 787165 SGTC_1396 3511-0007 98.6 µM 0.0636810256932061 0.478430067648223 no 1595 0.474612106690021 2237 X1396 SGTC_3345 9148410 3.559 µM 0.0635333807195726 0.478489375402764 no 1596 0.474670889478135 2270 4903596 SGTC_942 3253-1115 227 µM 0.0634703227371821 0.478514705413619 no 1597 0.474695995302925 2262 46497897 SGTC_2402 5553605 200 µM 0.0629664307472422 0.478717118893006 no 1598 0.474896617819248 2253 6758546 SGTC_392 N-ethylmaleimide 8.33 µM 0.0626810495514027 0.478831758995534 no 1599 0.475010243991363 2248 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2324 6149169 200 µM 0.0613198835005437 0.479378575141983 no 1600 0.475552227927397 2273 2888231 SGTC_2813 7971799 71.43 µM 0.0600622171991927 0.479883847243387 no 1601 0.476053040958571 2249 2234054 SGTC_1299 1079-1439 3.74 µM 0.0595949040634142 0.480071600309314 no 1602 0.47623913856255 2262 323161 SGTC_758 0868-0029 16 µM 0.059278791616202 0.480198607768202 no 1603 0.476365026621256 2311 762687 SGTC_2423 st077119 87.2 µM 0.0591554370214797 0.48024816964516 no 1604 0.476414151776217 2289 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2704 st078022 71.1 µM 0.0587641445793157 0.480405386623633 no 1605 0.476569983782831 2309 54697681 SGTC_1479 0549-0158 134 µM 0.058341050508119 0.480575384574127 no 1606 0.476738484802442 2295 5440202 SGTC_2923 7992654 58.14 µM 0.0572426083439561 0.481016751812643 no 1607 0.477175968616872 2267 2985126 SGTC_1349 flufenamic acid 69 µM 0.0571486392770199 0.481054510799219 no 1608 0.477213395582462 2284 3371 A non-steroidal anti-inflammatory. SGTC_181 1447-1644 8.07 µM 0.0561572977768313 0.481452865476184 no 1609 0.477608249443003 2302 534600 SGTC_1619 st003326 88.7 µM 0.0558953389909843 0.481558132521266 no 1610 0.477712591986596 2323 2849032 SGTC_1308 1187-1617 41.4 µM 0.0553081782693181 0.481794085267499 no 1611 0.477946473412229 2294 2882570 SGTC_655 k060-0012 42 µM 0.05386343419844 0.482374688092069 no 1612 0.478521984817648 2256 5994525 SGTC_2777 climbazole 1.536 µM 0.0538181067013613 0.482392904575152 no 1613 0.478540041681843 2321 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1258 0671-0043 57.1 µM 0.053615059551979 0.48247450681716 no 1614 0.478620928991279 2257 4298767 SGTC_2070 5230947 200 µM 0.0535220190517713 0.482511898936604 no 1615 0.478657993562387 2310 2835538 SGTC_277 nystatin 15.5 µM 0.0533483027371857 0.482581714333712 no 1616 0.478727197474891 2311 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3130 9127414 49.47 µM 0.052914729751467 0.482755966672812 no 1617 0.478899924097041 2323 1494646 SGTC_1795 st049545 62.3 µM 0.0523998113219909 0.482962915901264 no 1618 0.479105062227728 2342 5291882 SGTC_921 1561-0023 372 µM 0.0520930528142827 0.483086206422997 no 1619 0.479227274251518 2337 24050882 SGTC_3143 9086658 49.47 µM 0.051562800604195 0.483299325987544 no 1620 0.479438530353209 2210 25236626 SGTC_3333 9141820 12.094 µM 0.0515224071161629 0.483315561180041 no 1621 0.479454623632208 2212 1939433 SGTC_1650 st011916 45.8 µM 0.0514103788138998 0.483360588410536 no 1622 0.479499257306791 2305 242528 SGTC_695 3505-6186 243 µM 0.0504806984752108 0.483734260431693 no 1623 0.479869665088744 2276 1819379 SGTC_2258 7960471 200 µM 0.0494601938056517 0.484144454459718 no 1624 0.480276279546708 2175 2974708 SGTC_2351 9026858 72.31 µM 0.0486911431694777 0.484453587114417 no 1625 0.480582717116055 2315 1409300 SGTC_1150 3909-7983 10.9 µM 0.0479826803525504 0.48473837376405 no 1626 0.48086502289155 2289 23965914 SGTC_2716 st080858 38.6235 µM 0.0456743490577244 0.485666326006157 no 1627 0.48178490447641 2327 5296050 SGTC_2404 5161160 200 µM 0.0445960354533268 0.486099836411312 no 1628 0.482214651383822 2304 2831543 SGTC_2701 st077767 14.721 µM 0.0439067134252716 0.486376970620212 no 1629 0.482489381961936 2302 5721188 SGTC_1553 gossypol 38.6 µM 0.0433017303760382 0.486620202711899 no 1630 0.48273050593863 2313 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2518 prenyletin 46.28 µM 0.0418451336702644 0.487205844428027 no 1631 0.483311077518143 2328 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2776 terbinafine 19.92 µM 0.0415435607719852 0.487327098822936 no 1632 0.483431283168144 2330 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_330 1488-0319 80.1 µM 0.0401209666393567 0.487899101477821 no 1633 0.483998343148517 2242 6846614 SGTC_608 k048-0125 159 µM 0.0395086338321225 0.488145318570323 no 1634 0.484242435045023 2337 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_975 1335-0046 28.5 µM 0.0386726294485872 0.488481480575789 no 1635 0.48457569780756 2303 16486740 SGTC_2174 5790901 200 µM 0.0385511000245147 0.48853034891906 no 1636 0.484624144905332 2297 786020 SGTC_2075 5212009 200 µM 0.0384636867785119 0.488565498871339 no 1637 0.48465899189954 2332 780898 SGTC_1998 st075797 76.8 µM 0.03795930906975 0.488768317140881 no 1638 0.484860062643566 2341 24208315 SGTC_2989 9073649 71.4286 µM 0.0376654156159245 0.488886497698628 no 1639 0.484977225379703 2340 21367202 SGTC_470 aa-861 153 µM 0.0373029238281427 0.489032264389809 no 1640 0.485121737119638 2327 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2965 9082772 38.63 µM 0.0370696589117211 0.489126066614973 no 1641 0.485214732037261 2339 16459634 SGTC_2832 7992762 51.95 µM 0.0366308851434367 0.489302511215549 no 1642 0.485389658633095 2301 2985177 SGTC_405 ebelactone b 50 µM 0.0364373471046984 0.489380339557313 no 1643 0.485466817628645 2277 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2323 6148992 148.28 µM 0.0350602882559201 0.489934114066341 no 1644 0.486015833655372 2309 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3079 9117512 49.47 µM 0.0347230939131286 0.490069717392772 no 1645 0.486150272874698 2352 7185044 SGTC_342 k048-0088 23.3 µM 0.034341053481883 0.490223357042421 no 1646 0.486302594108737 2351 6820570 SGTC_518 1021-0119 62.6 µM 0.0333542785065532 0.490620200654227 no 1647 0.486696034911542 2205 1097762 SGTC_1464 k208-0027 110 µM 0.0331361194081058 0.490707937267983 no 1648 0.486783019716625 2329 X1464 SGTC_1547 harmine 94.2 µM 0.0330548411146395 0.490740624913921 no 1649 0.486815427311304 2339 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2747 doxorubicin 7.63 µM 0.0324096478232544 0.491000104127999 no 1650 0.487072684340321 2355 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2153 5569715 200 µM 0.0322368246459023 0.4910696095662 no 1651 0.487141594804773 2356 2054701 SGTC_35 0133-0054 64.071 µM 0.0318967314236991 0.491206387892509 no 1652 0.487277202630519 2321 99677 SGTC_360 0957-0399 1.01 µM 0.0316209943812698 0.491317284279427 no 1653 0.487387150332664 2339 6752301 YPR165W RHO1 SGTC_1235 benzylparaben 21.5 µM 0.0303466999703856 0.491829790729498 no 1654 0.487895276257801 2313 7180 SGTC_493 zm226600 134 µM 0.0301471121812744 0.491910063869425 no 1655 0.487974863850706 2338 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3124 9127567 49.47 µM 0.0299231771333433 0.492000129736326 no 1656 0.488064160722322 2356 17592030 SGTC_397 arbidol 50 µM 0.0292070443114637 0.492288158484028 no 1657 0.488349731541852 2348 131410 A RNA synthesis inhibitor. SGTC_2528 xanthyletin 44.79 µM 0.0264093338229474 0.493413435281587 no 1658 0.489465424716726 2339 65188 An natural product with antifungal activity of unknown mechanism. SGTC_899 1083-0020 478 µM 0.0263548724824787 0.493435340914556 no 1659 0.48948714408826 2356 767123 SGTC_1510 1123-0200 71.5 µM 0.0239059727565258 0.494420365481038 no 1660 0.490463805037419 2358 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1018 4259-0013 28.1 µM 0.0235871579568768 0.494548605461415 no 1661 0.490590957884319 2305 6801262 SGTC_154 3389-1638 511.116 µM 0.022998733850753 0.494785294487281 no 1662 0.490825641461921 2289 5238686 SGTC_1945 st075991 56.6 µM 0.0199096413778995 0.496027886118238 no 1663 0.492057726981516 2319 1084980 SGTC_811 0416-0114 265 µM 0.0195766347990332 0.496161840980883 no 1664 0.492190551495407 2306 6612453 SGTC_333 3486-0131 40.1 µM 0.0183419633583582 0.496658502223686 no 1665 0.492683025585125 2371 6744690 SGTC_2620 irigenin 100 µM 0.0177404617811475 0.49690046529695 no 1666 0.492922950943114 2364 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_275 trichlorophene 5.69 µM 0.0174962143454007 0.496998717839004 no 1667 0.493020376449975 2320 62616 SGTC_424 splitomicin 100 mM 0.0168456195656646 0.497260431145372 no 1668 0.493279887950388 2267 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1512 0259-0544 12.2 µM 0.0151036660587419 0.497961168379642 no 1669 0.493974738102164 2356 18476 SGTC_856 0433-0016 11.3 µM 0.0146694236699649 0.498135852527249 no 1670 0.494147956555162 2344 3911780 SGTC_3305 9127027 53.8275 µM 0.0140573585442469 0.498382070625049 no 1671 0.494392110021775 2361 41905295 SGTC_1739 st037196 92.5 µM 0.0133592464856415 0.498662903943428 no 1672 0.494670590265864 2376 612214 SGTC_1288 0973-0013 65.5 µM 0.0130191276635061 0.498799725632552 no 1673 0.494806266242473 2362 4315430 SGTC_2327 6189656 200 µM 0.0119890160488909 0.499214115758271 no 1674 0.49521718917538 2383 5349088 SGTC_1340 1486-1359 257 µM 0.0112751748727211 0.499501278110929 no 1675 0.495501951330385 2326 4309068 SGTC_3315 9136395 68.55 µM 0.0111492440272121 0.499551937306899 no 1676 0.495552187311258 2392 16876844 SGTC_2491 paeonol 100 µM 0.0101775084055598 0.499942845252779 no 1677 0.495939831681176 2376 11092 Increases levels of cortical cytochrome oxidase. SGTC_1728 st035614 33.7865 µM 0.00989335306289743 0.499942845252779 no 1678 0.496053187553014 2333 15945546 SGTC_1429 4049-0205 9.46 µM 0.00929416940424464 0.499701806767081 no 1679 0.496292216244216 2380 22774478 SGTC_1089 terbinafine 2.25 µM 0.00899314584532068 0.49958071160629 no 1680 0.496412302248726 2386 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2705 st078069 42.8 µM 0.00886198322933763 0.499527947780465 no 1681 0.496464626476613 2379 1530061 SGTC_570 0987-0065 62.6 µM 0.00849930134716869 0.499382048908987 no 1682 0.496609310161636 2388 3104428 SGTC_1073 triclabendazole 3.09 µM 0.00848644826528406 0.49937687840082 no 1683 0.496614437614511 2368 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3010 9080089 71.4286 µM 0.00829969981498603 0.499301753676755 no 1684 0.496688936842979 2394 17027233 SGTC_1914 st062367 72.6 µM 0.00787591643886404 0.499131275200436 no 1685 0.496857996418774 2388 978205 SGTC_1289 0976-0073 69.1 µM 0.00767526666965582 0.499050558385636 no 1686 0.496938041675332 2385 3391136 SGTC_1661 st013063 9.66 µM 0.00667777828491788 0.498649292255324 no 1687 0.497335971702394 2393 721395 SGTC_1179 1021-1431 9.29 µM 0.0065228754885308 0.498586978613795 no 1688 0.4973977676311 2381 2840958 SGTC_34 0469-0683 81.75 µM 0.00589316032492506 0.498333659833067 no 1689 0.497648982789423 2391 3690923 SGTC_2078 5212016 200 µM 0.00522268537947093 0.49806394514469 no 1690 0.497916459456828 2396 1899708 SGTC_1063 disulfiram 1.84 µM 0.00491269435065408 0.497939244082056 no 1691 0.498040126396288 2400 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2565 isoliquiritigenin 100 µM 0.00477966249695422 0.497885729002399 no 1692 0.498093197804123 2377 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1506 4226-2149 212 µM 0.00433594560677252 0.497707234102506 no 1693 0.49827021339206 2375 991114 SGTC_290 2043-6722 48.1 µM 0.00423622245227405 0.497667118327318 no 1694 0.498309996809285 2393 773758 YLR208W SEC13 SGTC_882 0843-0131 351 µM 0.00411509034064186 0.497618390372263 no 1695 0.498358321108804 2401 5425421 SGTC_1106 tegaserod maleate 11.7 µM 0.00303552646091917 0.497184114612263 no 1696 0.498789002011236 2387 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1859 st055998 20 µM 0.00255979017639536 0.496992741382969 no 1697 0.498978792584928 2402 676301 SGTC_1928 4'-methoxychalcone 40.3 µM 0.00213236926589582 0.496820804445623 no 1698 0.499149308387088 2403 641818 SGTC_733 4069-0007 56.1 µM 0.0019650480681883 0.496753496961155 no 1699 0.499216059747098 2397 5717425 YNL287W SEC21 SGTC_1632 st005650 90 µM 0.00173785681180964 0.496662105987648 no 1700 0.499306695789466 2400 2759605 SGTC_3267 9137951 49.47 µM 0.00116393277263725 0.496431237521282 no 1701 0.499535658110294 2402 16643986 SGTC_1257 0669-0121 16 µM 0.000967760800223383 0.496352325044629 no 1702 0.49961391935974 2400 4307855 SGTC_3185 9108267 49.47 µM 0.000499495879104264 0.49616396057093 no 1703 0.499800729983225 2402 4910486 SGTC_391 gliotoxin 8.33 µM 0.000464999943657005 0.496150084252559 no 1704 0.499814491868776 2402 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1775 st081588 35.1725 µM 0.000401737983370179 0.496124636539013 no 1705 0.499839729737102 2403 1426443 YGL099W LSG1 SGTC_2758 dehydroepiandrosterone 69.35 µM 7.698710594386e-05 0.495994002720237 no 1706 0.499969286588424 2405 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0 0.495963034060691 no 1707 0.5 2405 756377 SGTC_151 3013-0144 2.285 µM -0.000846909463863559 0.495622359817388 no 1708 0.499662132047582 2407 906558 YHR107C CDC12 SGTC_134 0269-0018 6.916 µM -0.00170058655931884 0.495278966486555 no 1709 0.499321564447011 2408 4378915 SGTC_2180 6301957 200 µM -0.00211163425693726 0.495113622954406 no 1710 0.499157580440222 2411 845462 SGTC_226 1,3-diallylurea 8.28947 mM -0.00233944092403219 0.495021988306294 no 1711 0.499066698954226 2425 74537 YKL182W FAS1 SGTC_1605 st000082 49.1 µM -0.00257276783515133 0.494928133426497 no 1712 0.498973615265198 2425 1114022 SGTC_1251 0490-5699 265 µM -0.0033156578125943 0.494629310598787 no 1713 0.498677246334848 2409 3883818 SGTC_2974 9094440 9.66 µM -0.00345712137714363 0.494572408104848 no 1714 0.498620810861451 2430 25236134 SGTC_829 1635-0120 117 µM -0.00351519078869597 0.494549050218766 no 1715 0.498597644658762 2413 285054 SGTC_2645 abamectin 100 µM -0.00495513951686749 0.49396985028273 no 1716 0.498023193430993 2414 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_560 2332-1943 155 µM -0.00508436176998961 0.493917872979442 no 1717 0.49797164186019 2410 21177716 SGTC_1008 4106-0037 6 µM -0.00535177167756261 0.493810312532022 no 1718 0.497864962194537 2411 2905394 SGTC_1699 st031318 29.054 µM -0.00619520585061068 0.493471060483877 no 1719 0.497528486260098 2430 5340658 SGTC_2233 sulbentine 40.3845 µM -0.00723356695692074 0.493053410059571 no 1720 0.497114249468696 2413 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1029 k015-0030 64.7 µM -0.00741376259087451 0.492980932391909 no 1721 0.497042363739525 2459 2208316 SGTC_671 0560-0003 407 µM -0.00826640086680984 0.492637990341855 no 1722 0.496702220745594 2427 3238678 SGTC_2857 9024691 58.44 µM -0.0088148415157441 0.492417403338617 no 1723 0.496483432564778 2443 16478292 SGTC_625 k213-0058 121 µM -0.0101893093364829 0.491864592256011 no 1724 0.495935124034985 2424 3655420 SGTC_3109 9122853 49.47 µM -0.0102284336543587 0.491848856675483 no 1725 0.495919516503731 2451 1234709 SGTC_771 0250-0039 27.3 µM -0.0107792986027913 0.491627303250467 no 1726 0.49569976531083 2425 3005115 SGTC_2014 4013930 200 µM -0.0120852054197529 0.491102088539857 no 1727 0.495178817948376 2425 64556 SGTC_2892 9047358 58.44 µM -0.0134719771931731 0.490544368154558 no 1728 0.494625621267265 2438 6466771 SGTC_1727 st034309 9.9045 µM -0.0145445459989473 0.490113023937957 no 1729 0.494197770223471 2436 870305 SGTC_2643 anethole 100 µM -0.0147426242610036 0.49003336604398 no 1730 0.494118756902086 2433 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_823 0417-1665 178 µM -0.0150068052236121 0.489927125327606 no 1731 0.494013375605558 2449 3429856 SGTC_908 3448-7491 47.7 µM -0.015136013969071 0.489875164122998 no 1732 0.493961834628064 2435 1203031 SGTC_2877 9040724 71.43 µM -0.0153607730776538 0.48978477781812 no 1733 0.493872179140596 2435 6463895 SGTC_959 1222-0044 107 µM -0.0170592837224686 0.489101743364008 no 1734 0.493194660532041 2439 6083612 SGTC_459 nigericin 15.3 µM -0.017543921608785 0.488906858174942 no 1735 0.493001346926337 2460 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1335 1486-0900 202 µM -0.017967113907393 0.48873668398007 no 1736 0.492832544237272 2439 X1335 SGTC_1985 st071382 65.5 µM -0.0181200545600881 0.488675183948673 no 1737 0.492771539676044 2440 6123237 SGTC_2477 5967686 25.23 µM -0.0183283256770276 0.488591435032112 no 1738 0.49268846531838 2438 776118 SGTC_2593 nobiletin 86.24 µM -0.0183294283762335 0.488590991621682 no 1739 0.492688025478932 2454 72344 An anti-infammatory. SGTC_1565 sinapyl alcohol 95.1 µM -0.0187186730264942 0.488434471909792 no 1740 0.492532765971697 2446 5280507 A phenol propionate derived from cinnamic acid. SGTC_1940 st075990 51.1 µM -0.0190762898064254 0.488290671694614 no 1741 0.492390122990995 2575 1084979 SGTC_453 enantio-paf c16 10 µM -0.0196712421463013 0.488051440568289 no 1742 0.49215281589123 2448 13871343 A lipid and platelet activating factor SGTC_730 1436-0052 41.2 µM -0.0196895530919204 0.488044077780481 no 1743 0.492145512295373 2437 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0200787292374891 0.487887591942938 no 1744 0.491990284167371 2436 16725076 SGTC_2124 5246320 200 µM -0.0209911107688784 0.487520735114126 no 1745 0.491626373346844 2476 579342 SGTC_1204 4049-0315 18.3 µM -0.0257624491593511 0.485602420698072 no 1746 0.489723406565211 2573 588402 SGTC_208 k072-0098 12.366 µM -0.0262017062762169 0.485425833646525 no 1747 0.489548227469647 2463 5948901 SGTC_558 k064-0027 21.3 µM -0.026351389688702 0.485365659626711 no 1748 0.489488533039563 2481 5088526 SGTC_1053 3366-3204 134 µM -0.0268807555405427 0.485152852681716 no 1749 0.489277421412527 2471 3632071 YPR165W RHO1 SGTC_211 3455-0679 143.504 µM -0.0270937285636895 0.485067237962458 no 1750 0.489192488403634 2479 748649 SGTC_1987 st072290 61.9 µM -0.0280046798511279 0.484701045227759 no 1751 0.488829209315309 2499 54697379 SGTC_3222 9128301 49.47 µM -0.0281410971262428 0.484646208036427 no 1752 0.488774808137187 2469 4911358 SGTC_1606 st000094 49.2 µM -0.0287195557734975 0.484413681725747 no 1753 0.488544129774142 2449 1242210 SGTC_2541 muurolladie-3-one 83.07 µM -0.0287727405208367 0.484392303015393 no 1754 0.488522920894453 2576 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3126 9127922 49.47 µM -0.0287873006030225 0.48438645029672 no 1755 0.48851711466718 2543 45595682 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0302236962029186 0.48380907885385 no 1756 0.487944325162441 2506 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2808 7946468 45.46 µM -0.0303264825835347 0.483767764280097 no 1757 0.487903338117661 2486 2970879 SGTC_2009 4012297 12.05 µM -0.0308869298784162 0.483542497813374 no 1758 0.487679856698634 2481 45595307 SGTC_1102 cgs 12066b 26.1 µM -0.0316528128305515 0.483234666944187 no 1759 0.487374462958894 2510 6438352 A 5-HT1B full agonist. SGTC_1907 st060210 83.7 µM -0.0334676448186969 0.482505272857448 no 1760 0.486650833532498 2463 688793 SGTC_251 melphalan 456.522 µM -0.0339293919181087 0.482319702609439 no 1761 0.486466727657415 2490 460612 A DNA alkylator. SGTC_3177 9107506 49.47 µM -0.0360502230767445 0.481467417535353 no 1762 0.485621156366288 2486 8897194 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0361646499560133 0.481421435898587 no 1763 0.485575536394303 2476 688669 SGTC_20 0481-0013 4.944 µM -0.0365298118450057 0.48127469981729 no 1764 0.485429954076113 2460 182045 SGTC_37 0566-0070 1.56 µM -0.0365964717112213 0.481247913594346 no 1765 0.485403378407036 2518 1626686 SGTC_2959 9079155 11 µM -0.0379196751341677 0.480716222705054 no 1766 0.484875862920616 2541 16189457 SGTC_2025 5147754 141 µM -0.0385040686596484 0.480481411993661 no 1767 0.484642893784934 2499 315777 YLR208W SEC13 SGTC_2086 5274770 176.623 µM -0.0395951988126943 0.480043011487705 no 1768 0.484207927615759 2497 689278 SGTC_557 1315-0110 16.2 µM -0.0396196744341136 0.480033177807545 no 1769 0.484198170911448 2483 6833801 SGTC_1991 st073000 8.92 µM -0.0396584668603819 0.480017592025403 no 1770 0.484182707126007 2558 4301969 YIL048W NEO1 SGTC_1971 st069429 63.5 µM -0.0403536007626939 0.479738310608073 no 1771 0.483905610660213 2479 1246522 YGL099W LSG1 SGTC_1563 conessine 56.1 µM -0.0412000706213122 0.479398240938318 no 1772 0.483568198687163 2492 441082 An anti-amoebic, histamine inhibitor. SGTC_2694 st077685 81.9 µM -0.0420453191216864 0.479058676913199 no 1773 0.483231285301959 2499 2838096 SGTC_2546 rhodinyl acetate 100 µM -0.04211059586962 0.479032453733205 no 1774 0.483205266691169 2488 6708682 SGTC_2195 6536160 144.242 µM -0.0428764872941262 0.478724784236986 no 1775 0.482899995965486 2487 3834386 SGTC_457 grayanotoxin iii 135 µM -0.0432198911932954 0.47858683810398 no 1776 0.482763124511732 2523 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1783 st039459 87.517 µM -0.044445320383222 0.478094601415019 no 1777 0.482274718438838 2568 729761 SGTC_1660 st012960 28.1 µM -0.0445346244099073 0.478058730612245 no 1778 0.482239126528791 2519 24207266 SGTC_87 0100-0052 35.5 µM -0.0448335103033973 0.477938678228003 no 1779 0.482120007289346 2502 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1808 st050063 61.5 µM -0.0459083025309411 0.477506987055074 no 1780 0.48169166834665 2476 4011993 SGTC_295 k015-0027 31 µM -0.0460445641535649 0.477452259338007 no 1781 0.481637365248397 2537 3887424 SGTC_56 0957-0365 83.25 µM -0.0464720714999309 0.477280559310273 no 1782 0.481466996871442 2479 6752360 SGTC_3253 9135987 49.47 µM -0.0465426550824237 0.477252211189185 no 1783 0.481438868532426 2498 4182430 SGTC_1864 st057645 30.4 µM -0.0472163754384783 0.47698163416232 no 1784 0.481170388182599 2482 688666 SGTC_2253 7938677 135.83 µM -0.0482019074893655 0.476585847649058 no 1785 0.480777664999942 2563 2301972 SGTC_2981 9013952 38.96 µM -0.0486707888415595 0.47639755448512 no 1786 0.480590827701973 2534 2996344 SGTC_740 k014-0057 261 µM -0.0492513710320079 0.476164411855775 no 1787 0.480359486372696 2556 4012779 SGTC_2200 6600604 21.907 µM -0.049612873657476 0.476019248459868 no 1788 0.480215443785787 2498 2904777 SGTC_1759 st043059 70 µM -0.0496986635712607 0.475984799507962 no 1789 0.480181260730445 2525 669426 SGTC_2016 5121758 140 µM -0.0497605980815397 0.475959929808233 no 1790 0.480156582969055 2493 2795203 SGTC_3072 9116419 49.47 µM -0.0502995560915237 0.475743516078347 no 1791 0.479941838755658 2521 17170162 SGTC_2334 9017922 200 µM -0.0519218110139536 0.475092157680156 no 1792 0.479295497519116 2566 3163164 SGTC_1025 k007-0731 70 µM -0.0531289188830162 0.47460752981815 no 1793 0.478814595024368 2501 6256118 SGTC_1755 st041960 45.185 µM -0.0538955302303437 0.474299771302323 no 1794 0.478509198925678 2550 2257073 SGTC_1313 1220-0047 237 µM -0.0550500099482664 0.473836330816204 no 1795 0.478049310994981 2532 3528706 SGTC_815 1582-0027 36.9 µM -0.0556182969762757 0.473608217455161 no 1796 0.477822944093403 2557 3128206 SGTC_659 k018-0002 107 µM -0.0558501510633631 0.473515152503155 no 1797 0.477730591244834 2519 6797879 YHR007C ERG11 SGTC_1515 3460-0031 42.1 µM -0.0561010998854389 0.473414424658961 no 1798 0.477630633869237 2528 2876596 SGTC_2863 9028737 58.44 µM -0.0562610076593807 0.473350240484686 no 1799 0.477566940494716 2591 6460917 SGTC_1445 4239-0156 97.7 µM -0.0570054032603865 0.473051462287135 no 1800 0.477270445481607 2619 4008346 SGTC_2420 aureobasidin a 50 nM -0.0571591453697017 0.472989756672193 no 1801 0.477209211097924 2686 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3261 9137475 49.47 µM -0.057841201732912 0.472716015777712 no 1802 0.47693755943055 2499 17027690 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0601329809182201 0.471796313488013 no 1803 0.476024861253737 2506 17037758 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0609510727584457 0.471468045363154 no 1804 0.475699087421348 2551 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1264 0783-0040 158 µM -0.0623644555133926 0.470900956172702 no 1805 0.475136300114728 2515 2855798 SGTC_778 3456-2434 196 µM -0.0627918031492802 0.470729503762245 no 1806 0.474966146564562 2667 5539063 SGTC_2034 5197015 53.07 µM -0.0637424097236762 0.470348138709636 no 1807 0.474587667656552 2587 780676 SGTC_2168 5727979 200 µM -0.0655852100823554 0.469608920459398 no 1808 0.473854032201913 2513 695210 SGTC_1772 st048439 82.2 µM -0.0668788749994013 0.469090044019764 no 1809 0.473339065343556 2567 2927068 YDL195W SEC31 SGTC_910 3454-3003 490 µM -0.0669831358657632 0.46904822827248 no 1810 0.473297564337239 2514 820824 SGTC_1184 1269-1718 139 µM -0.0672017600834092 0.468960546098743 no 1811 0.473210541975132 2588 5403821 SGTC_1620 st003704 16.5 µM -0.0680211778952093 0.468631921028824 no 1812 0.472884387902203 2532 2834414 SGTC_81 0411-0046 9.971 µM -0.0685583447646035 0.468416503440903 no 1813 0.472670588436601 2513 12925265 SGTC_1181 1222-0449 220 µM -0.0688879599269083 0.468284323944584 no 1814 0.472539401169066 2594 658318 SGTC_2397 5161689 200 µM -0.0696875000498357 0.467963713653237 no 1815 0.472221195554168 2587 2259942 SGTC_1092 toremifene 6.32 µM -0.0698103924093129 0.467914436468557 no 1816 0.472172287707144 2522 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_542 3381-0244 89.3 µM -0.0705430267881693 0.467620676117653 no 1817 0.471880727701554 2563 1112843 SGTC_1693 xanthone 101.9 µM -0.070981961791905 0.467444687215646 no 1818 0.471706055839403 2580 7020 An insecticide. SGTC_756 0508-1999 28.3 µM -0.071789513778638 0.467120919735902 no 1819 0.47138470904034 2542 6753853 SGTC_694 1315-0438 43.2 µM -0.0719454216933428 0.467058414911794 no 1820 0.47132267119907 2574 6793154 SGTC_2270 7924575 90.91 µM -0.0719686189690754 0.467049114993798 no 1821 0.471313440752712 2666 1262135 SGTC_1324 1418-0026 34.4 µM -0.0722457633005879 0.466938007668964 no 1822 0.471203163225511 2632 1372513 SGTC_1344 1488-0097 29.1 µM -0.0734149043083323 0.466469326812636 no 1823 0.470737978838538 2612 747966 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0738972128548631 0.466275994282938 no 1824 0.470546086803385 2566 551469 SGTC_934 2950-0684 338 µM -0.0739592594484075 0.466251123592162 no 1825 0.470521401343883 2652 1121253 SGTC_2591 skatole 100 µM -0.0749709599210083 0.465845613311068 no 1826 0.470118908737099 2602 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_167 3672-0051 66.205 µM -0.0755151592470211 0.465627501709278 no 1827 0.469902418320058 2538 3237971 SGTC_3218 9131285 49.47 µM -0.0762996169763002 0.465313114264775 no 1828 0.469590365283021 2557 17156417 SGTC_2533 agelasine 13.65 µM -0.0763703337227937 0.465284774146265 no 1829 0.469562235459067 2584 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2146 5545642 200 µM -0.0764984008730583 0.46523345099163 no 1830 0.469511293083776 2541 825326 SGTC_1452 4194-0072 190 µM -0.0770351844527903 0.465018340250427 no 1831 0.469297777487462 2633 1343545 SGTC_2896 9052656 71.43 µM -0.0772906543287381 0.464915966796226 no 1832 0.469196162716673 2551 6469436 SGTC_1548 st061468 90.8 µM -0.0776932398156475 0.464754644988645 no 1833 0.469036035849111 2557 390799 SGTC_2031 5180455 200 µM -0.077927732666656 0.464660682991404 no 1834 0.468942769503618 2543 29949 SGTC_2883 9059145 45.46 µM -0.0785908674765923 0.464394973543644 no 1835 0.468679025884306 2527 16476510 SGTC_551 k048-0028 34.9 µM -0.0793813815067987 0.464078245663316 no 1836 0.46836463865452 2600 6836383 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0800726996066365 0.463801280341768 no 1837 0.468089717784346 2597 5024745 SGTC_6 0844-0013 19.835 µM -0.0804804697596483 0.463637922097232 no 1838 0.467927564358512 2573 1584900 SGTC_1539 benzyladenosine 56 µM -0.0808626465502903 0.463484822465219 no 1839 0.467775593191085 2554 92208 A nucleotide analog. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0836038193197314 0.462386871308073 no 1840 0.466685715096235 2565 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2617 dihydrotanshinone i 20.83 µM -0.0842934961982773 0.462110672460312 no 1841 0.466411541640975 2584 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2305 7443522 69.23 µM -0.0844113597847444 0.462063472779347 no 1842 0.466364687860012 2587 5415886 SGTC_639 0833-0042 114 µM -0.084603977142931 0.461986338334732 no 1843 0.466288118552355 2580 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0858293880586785 0.461495650895367 no 1844 0.46580102219072 2571 688798 SGTC_362 0310-0100 9.03 µM -0.0859189634757111 0.461459784782456 no 1845 0.465765418290155 2635 790235 SGTC_2449 5812982 45.77 µM -0.0870221260760262 0.461018102839942 no 1846 0.465326962378276 2543 776185 SGTC_454 lyso-paf C-16 6.67 µM -0.0875416812950297 0.460810101026575 no 1847 0.465120477849634 2613 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2220 6782180 200 µM -0.0878662005852122 0.460680186488402 no 1848 0.464991510347387 2572 833803 SGTC_580 1123-0028 41 µM -0.0889265907026994 0.460255710726166 no 1849 0.464570125470183 2560 1677248 YPR107C YTH1 SGTC_2462 5162487 171.77 µM -0.0893874880093604 0.460071226931948 no 1850 0.464386983393811 2543 2259986 SGTC_2859 9028643 45.46 µM -0.0894539545338295 0.460044623022527 no 1851 0.464360572888396 2665 17151580 SGTC_2360 9040895 200 µM -0.0896939730093906 0.459948554651413 no 1852 0.464265202740075 2610 4914414 SGTC_60 0986-0278 202 µM -0.0914278783164545 0.459254621799288 no 1853 0.463576305409116 2560 3110598 SGTC_952 1185-0122 232 µM -0.0917904671842729 0.459109524348267 no 1854 0.463432259085741 2546 678600 SGTC_141 0443-0274 32.331 µM -0.0933633970737228 0.458480147164711 no 1855 0.462807434185268 2584 1627241 SGTC_1104 tacrolimus 29.8 µM -0.0934226760306605 0.458456429872682 no 1856 0.462783888214285 2559 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1494 4358-1428 177 µM -0.0941339252124643 0.45817187325531 no 1857 0.462501385800154 2572 1564571 SGTC_2594 a-mangostin 100 µM -0.0952012952933224 0.457744880034293 no 1858 0.462077470583245 2686 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0958257298973639 0.457495102334332 no 1859 0.46182949094426 2572 5106787 A p450 inhibitor. SGTC_780 0109-0199 192 µM -0.096157911089669 0.457362234639416 no 1860 0.461697578971455 2707 610414 SGTC_2108 5365811 200 µM -0.0964798101757657 0.457233484185427 no 1861 0.461569754130047 2649 780283 SGTC_1159 4092-0538 61.2 µM -0.096647953344357 0.457166233497159 no 1862 0.461502986726907 2579 717301 SGTC_2732 terfenadine 20 µM -0.0966956291868537 0.457147165248759 no 1863 0.461484055484929 2566 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_16 erodoxin 22.806 µM -0.097132637998488 0.456972385471039 no 1864 0.461310531012122 2589 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_861 0443-0273 110 µM -0.0976760629192971 0.456755056645653 no 1865 0.461094761835898 2661 6149169 SGTC_903 1134-0042 114 µM -0.0978302546401779 0.456693393984052 no 1866 0.461033541440344 2595 701009 SGTC_1221 2958-7315 257 µM -0.0985159378661488 0.456419195719828 no 1867 0.460761308466729 2660 4562705 SGTC_1753 st043925 64 µM -0.10012740081045 0.455774868785309 no 1868 0.460121590968994 2599 670181 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.100458297030389 0.45564257766116 no 1869 0.459990244724281 2773 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_53 0973-0023 39.979 µM -0.101323219150416 0.455296808158973 no 1870 0.459646942413462 2572 674768 SGTC_1271 0832-2808 169 µM -0.101443162149936 0.455248861270961 no 1871 0.459599337364965 2660 3663794 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.10188491079579 0.455072279077418 no 1872 0.459424013535791 2586 6312947 SGTC_1522 st012842 45.6 µM -0.102636587000495 0.454771828554245 no 1873 0.459125701969291 2585 3491067 YOR116C RPO31 SGTC_230 MPP+ 141.667 µM -0.103466307979681 0.454440213006991 no 1874 0.458796444142268 2625 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_590 k048-0076 22.4 µM -0.103671653995131 0.454358147019319 no 1875 0.458714961123925 2662 6832814 SGTC_3201 9113999 49.47 µM -0.103915453607479 0.454260715684212 no 1876 0.458618221648926 2782 16649224 SGTC_791 1348-1292 225 µM -0.104162900111698 0.454161829730603 no 1877 0.458520037596507 2679 5437054 SGTC_1290 0986-0249 10.2 µM -0.104430698235985 0.454054813950469 no 1878 0.458413781096576 2614 53329 SGTC_310 1273-0058 1.06 µM -0.104837799718634 0.453892137041734 no 1879 0.458252257733627 2615 2734232 SGTC_772 k072-0172 35.3 µM -0.107277087618425 0.452917565623618 no 1880 0.457284580531944 2625 5861980 SGTC_1793 st048256 72.231 µM -0.108037243485633 0.4526139173731 no 1881 0.456983074533582 2588 672022 SGTC_1926 methyl fluorone black 53.6 µM -0.109871653460093 0.451881267142763 no 1882 0.456255581836 2590 72721 Reacts with homocysteine. SGTC_2681 menadione 3.18 µM -0.111825070905258 0.451101266367438 no 1883 0.455481054244844 2635 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3193 9111931 49.47 µM -0.112633035930634 0.450778700456949 no 1884 0.455160746405321 2615 17087244 SGTC_2231 micatex 6.853 µM -0.11291862859965 0.450664690341582 no 1885 0.455047533650933 2627 20737 An antifungal of unknown mechanism. SGTC_3263 9137018 49.47 µM -0.113702193591888 0.450351907953965 no 1886 0.454736936783095 2623 43844957 SGTC_3166 9102297 49.47 µM -0.115897499375176 0.449475753657694 no 1887 0.453866888775666 2667 25237072 SGTC_2143 5623677 140.463 µM -0.116054101996166 0.449413262358188 no 1888 0.453804832118508 2590 5375313 SGTC_2417 cerulenin 830 nM -0.117895324717695 0.448678628417168 no 1889 0.453075298874287 2594 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1359 1582-0056 520 nM -0.118693895905533 0.448360059104891 no 1890 0.452758936361376 2717 3661189 SGTC_1559 coumarin 343 70.1 µM -0.119988855054391 0.447843539524628 no 1891 0.452245988274785 2733 108770 A hepatotoxic, DNA x-linker. SGTC_3003 9075612 71.4286 µM -0.120481628643136 0.447647010397232 no 1892 0.452050815924337 2719 6501993 SGTC_863 0466-0191 129 µM -0.121524770923224 0.447231024384145 no 1893 0.451637697871263 2619 765160 YPR165W RHO1 SGTC_1010 4112-3296 15.2 µM -0.121872352981001 0.447092427903139 no 1894 0.451500055753582 2690 704384 SGTC_826 1683-5028 118 µM -0.121947588591412 0.447062428957117 no 1895 0.451470263300545 2696 722377 SGTC_1407 3909-7909 12.3 µM -0.122842337561616 0.446705685981663 no 1896 0.451115973802802 2632 4411780 SGTC_3327 9140648 26.9345 µM -0.124074196428258 0.446214605432717 no 1897 0.450628264267587 2669 8029710 SGTC_1546 5-methoxyflavanone 78.7 µM -0.125541455271832 0.445629790375819 no 1898 0.450047454030887 2696 147795 SGTC_2472 5377652 49.4 µM -0.125804482601295 0.44552496629987 no 1899 0.449943346683056 2676 1610903 SGTC_640 3381-0960 37.1 µM -0.125968046743992 0.445459783129873 no 1900 0.449878609028876 2673 1745025 SGTC_1343 1487-0095 224 µM -0.126765624245454 0.445141955708939 no 1901 0.44956295203469 2629 4560101 YGL055W OLE1 SGTC_1148 3909-7663 27.7 µM -0.128472315166724 0.444461973516238 no 1902 0.44888760297165 2784 4084526 SGTC_1964 st076914 61 µM -0.130206075079713 0.443771373797679 no 1903 0.448201694140828 2621 24208661 SGTC_3202 9113761 49.47 µM -0.130499139077526 0.443654655924893 no 1904 0.448085767617604 2829 4798415 SGTC_2126 5251174 33.877 µM -0.130695409324545 0.443576490591785 no 1905 0.448008132011612 2702 790722 SGTC_3065 9113888 49.47 µM -0.13121937554326 0.443367829918185 no 1906 0.44780088450764 2793 16648368 SGTC_643 k048-0106 28.4 µM -0.131489003858832 0.44326046112303 no 1907 0.447694242350507 2754 6763920 SGTC_2163 5671233 125 µM -0.132145435443964 0.442999080681551 no 1908 0.447434629356836 2697 701023 SGTC_699 0375-0592 111 µM -0.132183514819006 0.442983918850303 no 1909 0.447419569984551 2649 762578 SGTC_2379 9035213 200 µM -0.132781115381713 0.442745986849232 no 1910 0.447183244920887 2630 646551 SGTC_1524 corynanthine 62.1 µM -0.133085959423702 0.442624622499492 no 1911 0.447062699561519 2842 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1408 3909-7976 48.8 µM -0.133371509609607 0.442510944292928 no 1912 0.446949788063129 2671 24152374 SGTC_1713 st033146 12.748 µM -0.133656406348108 0.442397530942272 no 1913 0.446837139234494 2715 674619 SGTC_1910 st062352 60.4 µM -0.134342110067746 0.442124581389433 no 1914 0.446566028002775 2611 2245730 SGTC_2686 alizarin 95.37 µM -0.134515941964099 0.442055390648388 no 1915 0.446497302894925 2698 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2676 harmalol 100 µM -0.134528322470604 0.442050462872074 no 1916 0.446492408275406 2653 5459187 A monoamine oxidase inhibitor SGTC_857 0438-0306 1.35 µM -0.134716944670004 0.441975387246569 no 1917 0.44641783770669 2722 4686136 SGTC_2516 gossypol 71.55 µM -0.135148959012351 0.44180344425724 no 1918 0.446247050769892 2763 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2148 5546263 113.568 µM -0.136551110681122 0.441245459448861 no 1919 0.445692811209677 2644 792097 SGTC_3149 9097855 49.47 µM -0.136870012364418 0.441118569089493 no 1920 0.445566771195891 2764 25236625 YMR079W SEC14 SGTC_2221 6807166 181.081 µM -0.137591504589123 0.44083151106337 no 1921 0.44528163501137 2661 674925 SGTC_753 1322-0200 289 µM -0.138157076745023 0.440606510232466 no 1922 0.445058138751899 2790 5403907 SGTC_332 4112-0506 40.9 µM -0.138588146903323 0.440435031027889 no 1923 0.444887805158816 2661 2790355 SGTC_2154 5570129 200 µM -0.139224401023082 0.440181950303833 no 1924 0.444636413525135 2636 673366 SGTC_3271 9137798 49.47 µM -0.139361229121839 0.44012752782688 no 1925 0.444582354008138 2673 6498326 SGTC_422 cantharidin 155 µM -0.139361564386693 0.440127394478877 no 1926 0.444582221549359 2631 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1499 4480-0877 67.3 µM -0.139663415095998 0.440007339350974 no 1927 0.444462966776759 2652 2861909 SGTC_1295 1013-0063 9.78 µM -0.139962640362611 0.439888333884873 no 1928 0.444344754222475 2683 6826038 SGTC_1737 st035557 69.7 µM -0.143337247492371 0.438546590793823 no 1929 0.443011920145501 2617 5716916 SGTC_2484 5809818 12.04 µM -0.144393706509091 0.43812668728757 no 1930 0.442594793105257 2718 2870548 SGTC_3258 9138477 49.47 µM -0.145310436631184 0.437762377290442 no 1931 0.442232887472485 2678 4970355 SGTC_2021 4019055 173 µM -0.146039901478042 0.437472524480969 no 1932 0.44194494463011 2769 44827708 YER133W GLC7 SGTC_1044 1222-0021 1.78 µM -0.148157213304232 0.43663140134416 no 1933 0.441109348960077 2802 4306703 SGTC_2512 diallyl trisulfide 49.23 µM -0.148273078933214 0.436585380804607 no 1934 0.441063630198552 2654 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2448 5185112 27.17 µM -0.149444744207083 0.436120056713499 no 1935 0.440601353674042 2802 5718189 SGTC_1001 4048-4355 44.4 µM -0.150525138217771 0.435691059113792 no 1936 0.440175159625205 2688 21824233 SGTC_739 1486-1183 203 µM -0.151780071432043 0.435192851352121 no 1937 0.439680200352345 2697 4346692 SGTC_1375 2910-0797 186 µM -0.152128921759299 0.435054376210978 no 1938 0.439542626711186 2749 742508 SGTC_2490 carminic acid 95.39 µM -0.152388410326087 0.434951378130382 no 1939 0.439440298770937 2627 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3100 9120536 49.47 µM -0.153578488553386 0.434479060311025 no 1940 0.438971049668627 2631 16421196 SGTC_902 1120-0002 2.07 µM -0.15515178061594 0.433854796343056 no 1941 0.438350830677686 2684 3280475 SGTC_450 aminopyrene 156 nM -0.155811870061511 0.433592929569062 no 1942 0.43809065697388 2716 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_23 0213-0011 39.996 µM -0.155941023554199 0.433541695966535 no 1943 0.438039754358975 2797 627608 SGTC_1155 4088-0394 48.2 µM -0.15631659289468 0.433392718575143 no 1944 0.437891738936451 2667 2326248 SGTC_2471 5466956 24.79 µM -0.157472926636535 0.432934094257036 no 1945 0.43743607154383 2729 724419 SGTC_456 gingerol 170 µM -0.157612420865162 0.432878774241873 no 1946 0.437381107740487 2841 442793 A herb. SGTC_1534 6-azauridine 81.6 µM -0.158162931935189 0.432660467802848 no 1947 0.437164206039449 2661 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_264 promethazine 12.5 mM -0.158769909977163 0.432419793080882 no 1948 0.436925078209025 2695 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_334 1502-1024 68.5 µM -0.159404974563646 0.432168008518337 no 1949 0.436674909944893 2790 3296216 SGTC_2787 5284540 71.43 µM -0.161146005229442 0.431477882280537 no 1950 0.435989203385023 2772 736958 SGTC_2996 9066192 71.4286 µM -0.161725371398595 0.431248273894445 no 1951 0.435761062031915 2736 6472854 SGTC_2357 9067248 200 µM -0.16197452854598 0.431149537659317 no 1952 0.435662956125534 2777 9150235 SGTC_602 3130-1533 38.1 µM -0.163451746906553 0.430564232719041 no 1953 0.43508138126077 2824 720941 SGTC_1180 1193-0155 285 µM -0.164908755206637 0.429987084808486 no 1954 0.434507900547473 2830 2921347 SGTC_539 4859-0462 2.54 µM -0.165517909886935 0.429745831650835 no 1955 0.434268177100361 2878 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_969 1313-0238 134 µM -0.165684532238313 0.429679846132127 no 1956 0.434202609644962 2712 5212874 SGTC_1136 pergolide 1.05886 µM -0.166178384844786 0.42948428295443 no 1957 0.434008284660016 2712 47811 A dopamine receptor agonist. SGTC_1794 st048918 76.9 µM -0.166542313151336 0.429340180225162 no 1958 0.433865093507748 2666 672303 SGTC_963 1269-2853 151 µM -0.166648215294392 0.429298248492349 no 1959 0.433823426902928 2735 3668223 SGTC_1368 1852-0141 284 µM -0.168695232098239 0.428487893751893 no 1960 0.433018184633232 2837 2838987 SGTC_1086 cerivastatin 2.18 µM -0.170339080154294 0.427837359902814 no 1961 0.432371739406182 2691 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1105 epirubicin 18.1 µM -0.171202136492896 0.427495893737793 no 1962 0.432032413809861 2703 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2301 7769476 200 µM -0.172283410666815 0.427068166876358 no 1963 0.431607362859579 2795 977820 SGTC_652 0437-0092 114 µM -0.172854302592246 0.426842369885859 no 1964 0.431382976055229 2718 3091274 SGTC_2096 5468907 200 µM -0.173334395919794 0.426652503761267 no 1965 0.431194294415671 2857 759785 SGTC_820 1582-0060 59.9 µM -0.173655284861038 0.426525608867587 no 1966 0.431068190496968 2751 3848840 SGTC_1042 0350-0096 82 µM -0.175182934027593 0.425921607547297 no 1967 0.430467946820647 2670 3122515 SGTC_1438 4092-1045 4 µM -0.175188323867092 0.425919476821471 no 1968 0.430465829329278 2710 1351342 SGTC_2899 9053889 58.44 µM -0.175949628041489 0.425618537767838 no 1969 0.430166757973718 2736 6470052 SGTC_289 k017-0060 526 µM -0.178358985291869 0.424666419368721 no 1970 0.429220528891857 2731 5512909 SGTC_3161 9100388 49.47 µM -0.179212160256008 0.424329370773641 no 1971 0.428885557898996 2742 25236368 SGTC_3057 9095946 49.47 µM -0.180122388617379 0.423969844121204 no 1972 0.428528243242893 2705 24540043 SGTC_263 alizarin 107.927 µM -0.182794745824314 0.422914669447466 no 1973 0.42747953568873 2704 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1625 st003711 30.1 µM -0.183513425795246 0.422630994163169 no 1974 0.427197592697416 2919 24207034 YER133W GLC7 SGTC_2204 7233102 200 µM -0.184624841235409 0.422192378513984 no 1975 0.426761650200259 2747 2172480 SGTC_1174 0739-0097 51.1 µM -0.185442485650426 0.421869759988399 no 1976 0.426440993765512 2796 728447 SGTC_2287 7945887 168.79 µM -0.185645488900801 0.421789668970486 no 1977 0.426361389301634 2831 1245853 SGTC_183 3914-0051 30.55 µM -0.188269270767038 0.420754798684031 no 1978 0.425332786481143 2860 1596232 SGTC_224 benfluorex 43.875 µM -0.188685757857037 0.420590578283235 no 1979 0.425169557331785 2818 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_394 menadione 8.33 µM -0.189585704409348 0.420235777577917 no 1980 0.424816895135721 2741 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_901 1112-0062 60.1 µM -0.192340056436326 0.419150288031941 no 1981 0.423737921807066 2748 1908457 SGTC_512 prima-1 270 µM -0.192627975505825 0.419036854556702 no 1982 0.4236251669735 2904 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1902 st060212 70.5 µM -0.192677631897032 0.419017291763596 no 1983 0.423605721175167 2748 688944 SGTC_2134 5324836 1.464 µM -0.19297345105306 0.418900754039386 no 1984 0.423489880132814 2793 699272 SGTC_3 0833-0587 95.581 µM -0.195116071106341 0.418056883592147 no 1985 0.422651040723269 2791 5382644 SGTC_164 4100-3994 89.624 µM -0.195612046043392 0.41786159757787 no 1986 0.422456915526604 2774 4615967 SGTC_573 3702-0553 84.7 µM -0.195948260176552 0.417729227568428 no 1987 0.422325331611451 2767 1222756 SGTC_661 1304-0007 33.6 µM -0.196249904730382 0.417610475792102 no 1988 0.422207284547947 2761 3117130 SGTC_2373 9071805 200 µM -0.196298798972651 0.417591227757673 no 1989 0.422188150692535 2820 10149009 SGTC_2962 9082311 13.18 µM -0.196433739882406 0.417538107041164 no 1990 0.422135345021692 2747 16459453 SGTC_1738 st035555 74 µM -0.197368604828363 0.417170130329224 no 1991 0.421769548044641 2867 5331140 SGTC_773 4358-1457 44.6 µM -0.197778402744441 0.417008850639627 no 1992 0.421609222249281 2813 1186886 SGTC_609 0986-0026 86.3 µM -0.198372471793359 0.416775074176076 no 1993 0.421376826886813 2765 2848610 SGTC_852 0418-0143 439 µM -0.198479754136463 0.416732859849984 no 1994 0.421334861754733 2856 5369229 SGTC_3007 9078383 71.4286 µM -0.19930702784091 0.416407369771015 no 1995 0.421011291018292 2799 6496995 SGTC_3346 9158254 43.5805 µM -0.199590838155486 0.416295718055967 no 1996 0.420900296853141 2857 17639500 SGTC_1621 st003705 32.4 µM -0.20011612675232 0.416089085982437 no 1997 0.420694880570263 2937 24207032 SGTC_3266 9136860 49.47 µM -0.202197129625955 0.415270713131965 no 1998 0.419881308507445 2761 4871271 YPR165W RHO1 SGTC_1757 st041620 31.8375 µM -0.202590092779418 0.41511621802185 no 1999 0.419727717123647 2838 5289815 SGTC_1050 3232-1156 69.3 µM -0.202697196388349 0.41507411206443 no 2000 0.419685857324587 2799 700529 SGTC_960 1222-0186 7.7 µM -0.204888705702918 0.414212772396966 no 2001 0.418829539787658 2889 3126296 SGTC_1390 3413-2614 145 µM -0.205390248424932 0.414015706445168 no 2002 0.418633619252046 2830 3421432 SGTC_3283 9109332 35.8195 µM -0.207542038608055 0.413170472245475 no 2003 0.417793282618428 2733 17027281 SGTC_1989 st071868 50.2 µM -0.208863304569289 0.412651671309569 no 2004 0.417277475528683 2921 16414057 SGTC_1708 st033234 31.827 µM -0.210915354340237 0.411846227630616 no 2005 0.41647666130106 2902 674664 SGTC_775 4577-0580 57.3 µM -0.212087628412651 0.411386268381779 no 2006 0.416019335630267 2989 2006902 SGTC_1327 1436-0082 2.18 µM -0.216145486950916 0.409795051054904 no 2007 0.414437172084926 2815 15992205 SGTC_2459 5811157 9.22 µM -0.216270603416566 0.409746012307995 no 2008 0.414388410952175 2768 2870684 YBR192W RIM2 SGTC_3322 9139058 2.11 µM -0.216384467363348 0.409701385154276 no 2009 0.414344036364701 2970 4908926 YPR165W RHO1 SGTC_3098 9119039 49.47 µM -0.219863853474864 0.408338262082781 no 2010 0.412988594114243 2779 17161528 SGTC_1211 1056-0033 32.3 µM -0.220051564416796 0.408264753717404 no 2011 0.412915498087963 2844 6741922 SGTC_1501 4491-0275 38.4 µM -0.221478990038893 0.407705873847581 no 2012 0.412359746967604 2796 5104718 SGTC_1019 4262-0212 3.4 µM -0.223436222074656 0.406939864355733 no 2013 0.411598007836626 2883 4677213 SGTC_568 1193-0097 7.48 µM -0.223693879804844 0.406839050294655 no 2014 0.411497754246712 2884 3646150 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.223844121143224 0.406780268027805 no 2015 0.411439298610756 2848 5357218 A potent inhibitor of glutathione S-transferases. SGTC_489 paxilline 115 µM -0.224688801446542 0.406449824061477 no 2016 0.411110688513831 2865 105008 A toxic potassium channel blocker. SGTC_3140 9094243 49.47 µM -0.224746831175521 0.406427124928483 no 2017 0.411088115212158 2766 19291112 SGTC_868 0527-0199 213 µM -0.22487966353876 0.406375166891896 no 2018 0.411036445132992 2834 2849450 SGTC_1227 3909-8010 46.6 µM -0.225138978016009 0.406273739501366 no 2019 0.410935579588233 2820 15982272 SGTC_1670 st016595 4.04 µM -0.226351074748953 0.405799727579806 no 2020 0.410464188551426 2814 597879 SGTC_618 k072-0232 33.2 µM -0.226798248425105 0.405624887214975 no 2021 0.410290312886107 2895 5872756 YGL099W LSG1 SGTC_361 000s-0510 1.45 µM -0.227087383050746 0.405511848533233 no 2022 0.410177897326899 2894 660 SGTC_1502 4534-4282 27.7 µM -0.228618230473031 0.404913487315194 no 2023 0.409582826964149 2839 3278949 SGTC_2726 cimetidine 79.27 µM -0.230330026958737 0.404244661923302 no 2024 0.408917664819337 2805 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_373 0844-0104 25.9 µM -0.230384065456889 0.404223552790602 no 2025 0.408896671043531 2932 5375804 SGTC_1434 4073-0095 163 µM -0.234164582464382 0.402747459761201 no 2026 0.407428604883419 2839 24133745 SGTC_2844 9010103 25.97 µM -0.234508742543438 0.40261315182994 no 2027 0.407295023417722 3015 2480525 SGTC_1395 3486-0190 4.35 µM -0.234580989567209 0.402584959001233 no 2028 0.407266983000204 2961 6748079 SGTC_2156 5649887 115 µM -0.234693654453918 0.4025409949922 no 2029 0.407223256604602 2927 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3233 9132340 49.47 µM -0.235231727683149 0.40233104546221 no 2030 0.407014440833133 2839 17682950 SGTC_2303 7774051 200 µM -0.236034983780991 0.402017677286533 no 2031 0.406702761932983 3008 2953184 SGTC_2931 9014674 55.67 µM -0.236197915333805 0.401954121718335 no 2032 0.406639548541573 2842 2996810 SGTC_1253 0550-0034 176 µM -0.237812000524666 0.401324647330029 no 2033 0.406013455293133 2946 5969915 SGTC_2625 euphol 100 µM -0.238140975148347 0.401196382420007 no 2034 0.405885877582476 2968 6708538 A triterpene alcohol. SGTC_1872 amphotericin b 148 nM -0.238149253914724 0.40119315472406 no 2035 0.405882667171727 2958 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.238613437780272 0.401012191166617 no 2036 0.40570267211984 2992 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1056 3448-1962 115 µM -0.238809824949618 0.400935635394307 no 2037 0.405626525711823 2927 715507 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.239191351840753 0.400786919213068 no 2038 0.405478604148372 2815 3256 An antibiotic and ribosome inhibitor. SGTC_2311 7694451 200 µM -0.240038902278887 0.40045660219511 no 2039 0.405150049202939 2909 2163142 SGTC_3058 9093861 49.47 µM -0.240346581998794 0.400336707345509 no 2040 0.405030792950721 3008 17217477 SGTC_491 tetrandrine 80.3 µM -0.241087591501914 0.400047993623252 no 2041 0.404743614863222 2934 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_144 4161-2749 112.381 µM -0.242648731568367 0.399439917801269 no 2042 0.404138763399992 2840 797501 YMR168C CEP3 SGTC_3076 9116187 49.47 µM -0.242889468237193 0.399346170719874 no 2043 0.404045512219095 2950 27241210 SGTC_2630 antimycin a 100 µM -0.243473976208651 0.399118577226588 no 2044 0.403819121308655 2778 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.243613586090404 0.399064221531389 no 2045 0.403765052544141 2932 6708739 YPR165W RHO1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.243887647502031 0.398957524185996 no 2046 0.40365891811463 2974 61125 An anti-inflammatory. SGTC_1678 st019265 80.2 µM -0.24391603522434 0.398946472734524 no 2047 0.403647924944846 3070 5367020 SGTC_1717 st033143 58.0435 µM -0.244732244253756 0.398628754045326 no 2048 0.40333187988947 3005 674616 SGTC_1382 3002-2117 298 µM -0.245185762541533 0.398452245887935 no 2049 0.403156299921572 2984 1497314 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.245926588586676 0.398163962981687 no 2050 0.402869530533042 2814 16486 A toxic proline analog. SGTC_2652 actinonin 100 µM -0.248107660601644 0.397315550167235 no 2051 0.402025554298854 2826 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3139 9095020 49.47 µM -0.248153252391567 0.39729782063453 no 2052 0.402007917196705 2778 25236292 SGTC_1602 st001878 87.6 µM -0.248345987544019 0.397222872989838 no 2053 0.401933360153886 3021 595405 YLR310C CDC25 SGTC_719 2810-4230 27.3 µM -0.249333899123622 0.396838769979566 no 2054 0.401551255715803 2823 721079 SGTC_720 r052-1644 49.9 µM -0.249970793417738 0.396591196576621 no 2055 0.401304967612466 2966 1422863 YOR257W CDC31 SGTC_1617 st002906 78 µM -0.250294071649768 0.396465547879169 no 2056 0.401179970367384 2830 5150859 SGTC_937 3122-0005 46.7 µM -0.252764541462408 0.395505705184556 no 2057 0.400225084949856 3010 759535 SGTC_2080 5212524 12.4 µM -0.254145807577639 0.39496932258822 no 2058 0.399691457752962 2895 260183 SGTC_1709 st033179 39.1045 µM -0.254297460616141 0.39491044376003 no 2059 0.399632880736067 2857 573381 SGTC_3199 9111318 49.47 µM -0.25432466192794 0.394899883187744 no 2060 0.399622374283392 2986 8548020 SGTC_284 0988-0104 32.6 µM -0.256232196963754 0.394159499338289 no 2061 0.39888577434735 2941 4666532 SGTC_1814 st052110 31.539 µM -0.259244301206648 0.392991171320938 no 2062 0.397723375862405 2991 674163 SGTC_67 0335-0847 266 µM -0.259394317201117 0.392933008560794 no 2063 0.397665506960971 3214 4552207 YOR254C SEC63 SGTC_2047 4141938 200 µM -0.260242469042995 0.39260421627274 no 2064 0.397338373469391 2885 3807862 SGTC_2994 9053520 71.4286 µM -0.26070016877702 0.392426817430099 no 2065 0.397161867945765 3007 4647384 SGTC_3287 9117173 37.0625 µM -0.261180603461507 0.392240630841263 no 2066 0.396976617660871 2931 2789709 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.262247570848415 0.391827228950688 no 2067 0.396565290061189 2930 4213774 SGTC_136 0097-0015 404.482 µM -0.263056678484474 0.391513817498555 no 2068 0.396253446913824 2868 4861337 SGTC_234 nsc-17383 10.7 µM -0.263471465715681 0.391353175100756 no 2069 0.396093606937438 3016 408974 SGTC_1303 1160-0052 261 µM -0.263711601124938 0.391260181843163 no 2070 0.396001077745265 2892 3562476 SGTC_252 miconazole 1.30953 nM -0.264614218702959 0.390910695732976 no 2071 0.395653332771954 2975 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_972 1319-0219 195 µM -0.265094321667475 0.390724839678466 no 2072 0.395468400778239 2978 23903702 SGTC_2499 avocadenofuran 51.48 µM -0.265647537230717 0.390510711442779 no 2073 0.39525533555689 2855 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_669 0108-0021 26.2 µM -0.266082641650903 0.390342322761878 no 2074 0.395087781607509 2994 17201 SGTC_722 3534-0461 190 µM -0.267951331902088 0.389619359831056 no 2075 0.394368390363409 2923 658262 SGTC_2033 5192550 145 µM -0.268413134375442 0.389440755428202 no 2076 0.394190665284419 2914 182073 SGTC_981 1488-1094 54.9 µM -0.268685530446229 0.389335415839946 no 2077 0.394085843748969 2833 3449522 SGTC_2048 5246248 200 µM -0.269030069659358 0.389202189080039 no 2078 0.393953271587231 2994 677046 SGTC_2950 9072895 21.46 µM -0.269411352075896 0.389054769604505 no 2079 0.393806575660778 3015 17332245 SGTC_2054 5233173 129 µM -0.270592818063755 0.388598067728164 no 2080 0.393352110090011 3046 6889 SGTC_427 1354-0053 47.3 µM -0.271768695408202 0.388143679017491 no 2081 0.392899938498021 3112 6813657 SGTC_2809 7964133 12.99 µM -0.273371667194116 0.387524496905999 no 2082 0.392283764943951 2928 1253665 SGTC_1402 3909-7673 35.9 µM -0.273693541834636 0.38740020037295 no 2083 0.392160070597515 2843 5328014 SGTC_1818 st052136 56.3 µM -0.273969487171637 0.387293649290842 no 2084 0.392054035260519 2982 674169 SGTC_1463 k081-0032 34.1 µM -0.274210236630011 0.387200695367499 no 2085 0.391961530913399 2962 977755 SGTC_563 tetrahydrosecaminediol 614 µM -0.276727776842329 0.386229055647247 no 2086 0.39099457081289 3048 334274 A psychoactive constituent of the cannabis plant. SGTC_402 epigallocatechin gallate 10 µM -0.277225532817542 0.386037031940032 no 2087 0.390803467655953 2918 65064 An antioxidant. SGTC_1822 st052468 42 µM -0.27755253817399 0.385910895394281 no 2088 0.390677935032138 2945 2873678 SGTC_2762 leflunomide 42.06 µM -0.278229334877514 0.385649871336124 no 2089 0.390418158777748 2894 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_601 0986-0029 62.9 µM -0.279006027961523 0.385350383478023 no 2090 0.390120099373882 2918 24747981 SGTC_12 0849-0099 9.267 µM -0.280735124963741 0.38468390051577 no 2091 0.389456782928582 2945 6071388 SGTC_1741 st038134 10.228 µM -0.283811554014092 0.383498929807726 no 2092 0.388277399822996 3144 1272587 SGTC_2293 7624732 200 µM -0.284163525300188 0.383363427657952 no 2093 0.388142533161276 2861 894453 SGTC_2450 5739737 12.93 µM -0.284198380932734 0.383350009688447 no 2094 0.388129178081682 3003 2262825 SGTC_2580 diallyl disulphide 81.36 µM -0.28594505686151 0.382677791575443 no 2095 0.387460101718475 2903 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2972 9093619 59.92 µM -0.287231653147805 0.382182863554387 no 2096 0.386967475635741 2893 25236256 SGTC_2486 5283202 22.39 µM -0.287403202195261 0.382116886568365 no 2097 0.386901804793185 2962 1377751 SGTC_117 lucigenin 22.078 µM -0.287883347105605 0.381932243215457 no 2098 0.386718017313908 2984 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2309 7664088 163.95 µM -0.288030512748607 0.381875654930485 no 2099 0.38666169106582 3098 704922 SGTC_2052 5265182 7.135 µM -0.289045209713116 0.381485551360459 no 2100 0.386273390509847 3071 1239884 SGTC_2218 6965428 192.983 µM -0.289727751422753 0.381223213650798 no 2101 0.386012261958581 2977 675684 SGTC_220 paclitaxel 373.376 µM -0.289840394397316 0.381179924103956 no 2102 0.385969171682374 3018 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1969 st069479 40.1 µM -0.290407699767745 0.380961926970965 no 2103 0.385752176922739 3098 3895485 SGTC_945 3381-0768 11.3 µM -0.292489783715016 0.380162173590584 no 2104 0.384956084979436 3071 1126236 YIL048W NEO1 SGTC_3096 9117468 49.47 µM -0.292505984867515 0.380155952537405 no 2105 0.384949892309388 3051 41316311 SGTC_1579 chlormadinone acetate 49.4 µM -0.292541996246552 0.380142124699856 no 2106 0.384936127554974 3075 45114258 A steroidal progestin. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.295173126166247 0.379132225269384 no 2107 0.383930815042058 2945 66535 A nucleotide analog. SGTC_3342 9147791 14.508 µM -0.296442703826608 0.378645221159701 no 2108 0.383446008554072 2926 1838168 SGTC_3112 9123419 49.47 µM -0.29665606242001 0.378563396678917 no 2109 0.383364552392232 2911 17015854 SGTC_2495 cafestol 54.53 µM -0.297111883013679 0.37838860460492 no 2110 0.383190546230745 3123 16667697 An anti-infammatory. SGTC_256 clotrimazole 625 nM -0.298075068218744 0.378019336912283 no 2111 0.382822934902254 2992 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_398 bronopol 33.3 µM -0.299498775444364 0.377473717589461 no 2112 0.382279753114276 2904 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3117 9124945 49.47 µM -0.300090614209095 0.377246974096835 no 2113 0.382054019125567 2881 17592065 SGTC_496 calpeptin 138 µM -0.301353895959983 0.376763131021324 no 2114 0.381572323396556 2991 73364 A calpain inhibitor. SGTC_1334 1486-0610 236 µM -0.302892288314299 0.376174180592983 no 2115 0.380985974253068 3026 3742339 SGTC_2963 9082507 9 µM -0.303845325119494 0.375809469252559 no 2116 0.380622866859976 3109 16459611 SGTC_283 0987-0079 11.7 µM -0.305910875594213 0.37501939852965 no 2117 0.379836252574328 3047 411556 SGTC_1874 staurosporine 7.6 µM -0.30656125133029 0.37477073888854 no 2118 0.379588675625281 3068 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1729 st035615 45.989 µM -0.307411873003126 0.374445597339337 no 2119 0.379264946048806 3048 17385451 SGTC_257 daunorubicin 18.5 µM -0.307631889613082 0.3743615127316 no 2120 0.379181225901714 3049 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3170 9103054 49.47 µM -0.308203326410077 0.374143152420246 no 2121 0.378963810739967 3009 16432970 SGTC_3064 1327-0027 10 µM -0.309977447422899 0.3734654738874 no 2122 0.378289053292137 2922 16000455 YPR107C YTH1 SGTC_950 1165-0508 94.1 µM -0.310234276114235 0.373367402854833 no 2123 0.378191403460466 3037 6148369 SGTC_2612 dictamnine 15.46 µM -0.311047534983639 0.373056910933319 no 2124 0.377882242506714 3032 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2629 bisabolol 100 µM -0.312593603895597 0.372466868887602 no 2125 0.377294719065223 3125 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3009 9080819 71.4286 µM -0.313566432054455 0.372095751829793 no 2126 0.376925178935714 3026 17027216 SGTC_3105 9121040 49.47 µM -0.314105748277251 0.371890063205731 no 2127 0.376720361916115 2974 41448907 SGTC_2688 kanamycin b 96.69 µM -0.314991982928288 0.371552143548828 no 2128 0.376383870479092 3109 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3071 9117417 49.47 µM -0.315587138104912 0.371325267492361 no 2129 0.376157950723468 3011 45595590 YGL055W OLE1 SGTC_796 1234-0020 70.7 µM -0.316757087738042 0.370879407361509 no 2130 0.375713963852889 2954 46495034 SGTC_761 k216-0224 480 µM -0.31686283664399 0.370839115678618 no 2131 0.37567384105645 3159 1340404 SGTC_1845 st056753 3.01 µM -0.321648291427827 0.369017284752755 no 2132 0.373859577527297 2923 5375839 SGTC_1240 0356-0016 42.1 µM -0.322112139726267 0.36884085248426 no 2133 0.373683870923887 2995 4305613 SGTC_1571 st070080 73.4 µM -0.323898589909567 0.368161605499464 no 2134 0.373007405790324 3120 4315245 SGTC_1884 5633444 25 µM -0.326383776034735 0.367217369474489 no 2135 0.372067005451072 3142 5724239 SGTC_2827 7993847 71.43 µM -0.326969444092483 0.366994963986271 no 2136 0.371845498089289 3075 2985692 SGTC_3069 9117009 49.47 µM -0.328037816913232 0.366589367988648 no 2137 0.371441534740897 3037 41904981 SGTC_2843 9000894 45.46 µM -0.328319121464558 0.366482598560076 no 2138 0.371335193964937 3051 2242070 SGTC_3311 9131146 2.8755 µM -0.328701432719795 0.366337508499473 no 2139 0.371190685651057 3017 4900406 YPR165W RHO1 SGTC_546 peri-Naphthalide 147 µM -0.330089427091088 0.365810914685528 no 2140 0.370666195942396 3030 223824 A penicillin ester. SGTC_543 3844-1095 191 µM -0.332169984789085 0.365022041560279 no 2141 0.369880453446079 3064 4230703 SGTC_617 3770-0098 35 µM -0.332499372375355 0.364897201825264 no 2142 0.369756106771852 3011 5962639 SGTC_1128 3448-9350 235 µM -0.333391185872868 0.364559271439973 no 2143 0.369419507814186 3061 619386 SGTC_2935 9038016 29.96 µM -0.333862795748427 0.364380609209989 no 2144 0.369241547586912 3161 6463195 SGTC_197 4544-0043 41.561 µM -0.334304248759164 0.364213398144112 no 2145 0.369074992327437 2983 896523 SGTC_2181 6316240 54.2555 µM -0.334781879313779 0.364032513060489 no 2146 0.368894815370356 3075 12779990 SGTC_3049 9092223 49.47 µM -0.33674580116611 0.363289068286288 no 2147 0.368154266710238 3096 8623917 SGTC_1230 0170-0365 3.77 µM -0.338263439694287 0.362714916934575 no 2148 0.367582336197242 3115 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1077 5-fluorocytosine 377 nM -0.3413951860307 0.361531094563058 no 2149 0.366403049327265 3068 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2375 9072683 200 µM -0.341762151254415 0.361392465564558 no 2150 0.366264947601932 3177 16798029 SGTC_2292 7671323 168.05 µM -0.346326749702432 0.359669616538785 no 2151 0.364548583847965 3176 937504 SGTC_3006 9075424 71.4286 µM -0.348702899089352 0.35877389431269 no 2152 0.36365618378318 3041 7465181 SGTC_1816 st051957 91.6 µM -0.348827396403766 0.358726984691645 no 2153 0.363609447208271 3034 674121 SGTC_2384 9036245 200 µM -0.349097678127955 0.358625151973132 no 2154 0.36350798982147 3055 6462766 SGTC_413 propylparaben 100 µM -0.350353427170503 0.358152161492754 no 2155 0.363036736895257 3006 7175 A pharmaceutical preservative. SGTC_2288 7946289 167.31 µM -0.350401281322362 0.358134141046151 no 2156 0.363018782459462 3218 1246052 SGTC_2241 6772625 37.8075 µM -0.35059437461236 0.358061431081893 no 2157 0.362946338699098 3021 2285411 SGTC_2984 9022109 38.96 µM -0.352413417018511 0.357376717214508 no 2158 0.362264120639166 3149 6459207 SGTC_2795 7780010 54.55 µM -0.355114037818056 0.356361011415335 no 2159 0.361252080244387 3169 953673 SGTC_845 0330-0138 4.51 µM -0.357442687120552 0.355486021451824 no 2160 0.36038021243845 3092 9039800 SGTC_1304 1165-0502 251 µM -0.35905130741167 0.354882026554633 no 2161 0.359778353530402 3046 767425 SGTC_2390 9097792 176.6 µM -0.359430676966649 0.354739636266046 no 2162 0.35963646450718 3044 4497149 SGTC_1805 st050013 60.3 µM -0.35960896749241 0.354672724779717 no 2163 0.359569788271599 3069 4037144 SGTC_846 0335-0850 148 µM -0.359854161614304 0.354580712052931 no 2164 0.359478098732399 3110 6819598 SGTC_2820 7989630 71.43 µM -0.360886726591513 0.354193319906687 no 2165 0.359092063263174 3119 2984098 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.361468842379078 0.353974991315244 no 2166 0.358874496418714 3055 4174840 SGTC_2722 naftopidil 47.16 µM -0.36209064262273 0.353741831680035 no 2167 0.358642147999689 3163 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_217 ketoconazole 989 nM -0.363277517242363 0.353296935534502 no 2168 0.358198793220276 3122 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3325 9138760 55.175 µM -0.363929929852444 0.353052466074615 no 2169 0.357955167085223 3059 43844959 SGTC_1470 k295-0292 231 µM -0.364101331055635 0.352988249351704 no 2170 0.357891171455078 3150 5045612 SGTC_2801 7907800 81.82 µM -0.364216933517342 0.352944940402399 no 2171 0.357848011513768 3136 6620925 SGTC_3337 9144342 33.5465 µM -0.364219353710114 0.352944033729211 no 2172 0.357847107959193 3143 17682949 SGTC_1627 st003713 25.6 µM -0.365276633944479 0.352548026347616 no 2173 0.357452459279737 3125 16195070 YER133W GLC7 SGTC_2575 plumbagin 510 nM -0.365776669378798 0.352360792241681 no 2174 0.357265865200952 2992 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2614 arthonioic acid 13.39 µM -0.366086471851032 0.352244807229555 no 2175 0.357150275898318 3032 6710684 SGTC_2691 st077356 60.2 µM -0.368158493921174 0.351469429589842 no 2176 0.356377528581902 3210 2839272 SGTC_2386 9075165 157.42 µM -0.368185217272108 0.351459433391522 no 2177 0.356367566122599 3079 16452277 SGTC_767 0929-0023 86 µM -0.370308600839365 0.350665484533589 no 2178 0.355576283040671 3135 1204563 SGTC_2409 alverine citrate 63.97 µM -0.370512788722508 0.350589171468752 no 2179 0.355500224752977 3281 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.371155742683134 0.350348913611525 no 2180 0.355260767349158 3358 5282309 SGTC_2173 5763948 167 µM -0.371854742364721 0.350087780615829 no 2181 0.355000501484915 3075 2867177 SGTC_296 1222-0039 74.9 µM -0.372181823800802 0.349965613540275 no 2182 0.354878739056113 3087 5984176 SGTC_1958 st076513 41.9 µM -0.372331092669359 0.349909865792167 no 2183 0.354823175740219 3031 732122 YGL099W LSG1 SGTC_1889 st059080 5.18 µM -0.372720282239284 0.349764529588112 no 2184 0.354678319715139 3231 176925 Isolated from Daphnopsis sellowiana. SGTC_1591 genipin 88.4 µM -0.373113914991725 0.349617556543672 no 2185 0.354531831313704 3179 442424 A DNA cross-linking agent. SGTC_3122 9126309 49.47 µM -0.374619021484875 0.349055793822986 no 2186 0.353971912245729 3150 17591206 SGTC_1862 st057513 3.81 µM -0.374878521244792 0.348958972071354 no 2187 0.353875406850008 3038 5393163 SGTC_2675 theaflavin digallate 100 µM -0.375131771887612 0.348864491403476 no 2188 0.353781234490416 3130 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_954 1189-0853 2.85 µM -0.375642808942425 0.348673866437651 no 2189 0.3535912303715 3083 2828194 SGTC_2388 9080168 200 µM -0.377244093906952 0.348076809190317 no 2190 0.352996107299544 3047 15943073 SGTC_897 1000-0139 31.4 µM -0.377259067112063 0.348071228035119 no 2191 0.352990544150254 3211 6151020 SGTC_2192 5915882 198.485 µM -0.378256518919171 0.347699509170618 no 2192 0.352620021421105 3104 2876149 SGTC_115 0527-0192 112.043 µM -0.379073231661529 0.347395255026567 no 2193 0.352316741766728 3163 4233931 SGTC_951 1171-0579 82.7 µM -0.379387871202597 0.347278066980493 no 2194 0.352199927965195 3046 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1930 st074634 34.3 µM -0.381541541533756 0.346476321193685 no 2195 0.351400726227588 3038 684253 YOR116C RPO31 SGTC_622 1348-1566 26.3 µM -0.382140688231234 0.346253399193523 no 2196 0.351178506510817 3146 7340407 SGTC_276 colchicine 750 µM -0.383233224449893 0.345847040961218 no 2197 0.350773422755256 3217 2833 A microtubule depolymerizer. SGTC_1754 st042065 16.137 µM -0.384164555142543 0.345500781680172 no 2198 0.350428243648366 3161 1126236 YIL048W NEO1 SGTC_411 enrofloxacin 100 µM -0.384889607526923 0.345231304031057 no 2199 0.350159602943663 3260 71188 A bacterial gyrase inhibitor. SGTC_584 0986-0246 15.4 µM -0.387446000184614 0.34428180534202 no 2200 0.34921302731176 3200 53315 YDR232W HEM1 SGTC_854 0422-0053 192 µM -0.388401553354534 0.343927144003208 no 2201 0.348859447436781 3129 3596728 SGTC_2411 st077133 39.94 µM -0.389473375365734 0.343529491891261 no 2202 0.348463001157694 3349 1403142 YNL221C POP1 SGTC_1300 1094-0077 113 µM -0.390458304190258 0.343164230257141 no 2203 0.348098840865593 3095 5532636 SGTC_3019 9081971 49.47 µM -0.391521514082088 0.342770102431371 no 2204 0.347705894674736 3263 16451803 SGTC_615 k087-0205 167 µM -0.392103138092534 0.342554569002334 no 2205 0.347491004471679 3096 9642773 SGTC_3165 9101544 49.47 µM -0.392212704147954 0.342513972652091 no 2206 0.347450529040113 3179 5002184 SGTC_2412 st077135 33.4 µM -0.393802368170992 0.341925176156002 no 2207 0.346863477932014 3319 13258915 SGTC_1205 4161-2785 76 µM -0.394212848503524 0.341773200492358 no 2208 0.346711950226957 3179 3498106 SGTC_2489 cantharidin 73.42 µM -0.394883845526859 0.341524826715799 no 2209 0.346464306295879 3113 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_599 1935-0052 86.5 µM -0.397169012551577 0.340679472997428 no 2210 0.34562141566306 3089 9557311 SGTC_1465 k213-0056 144 µM -0.397799208927034 0.340446484411925 no 2211 0.345389100218818 3083 24048857 YMR208W ERG12 SGTC_159 3970-0959 50 µM -0.398866800382365 0.340051926370447 no 2212 0.344995676478983 3262 6615653 SGTC_2061 5245884 80.95 µM -0.40076687214833 0.339350135505773 no 2213 0.344295885614672 3090 573863 SGTC_1806 st050005 60.3 µM -0.401094667040134 0.33922912082463 no 2214 0.344175213532147 3121 5194765 SGTC_1021 4476-0760 85.3 µM -0.402674949727305 0.338645947987296 no 2215 0.343593682285026 3112 746768 SGTC_620 0109-0052 432 µM -0.40330145660421 0.33841485466057 no 2216 0.343363235156654 3264 493037 SGTC_126 0417-1624 672.48 µM -0.403394112808938 0.338380682655362 no 2217 0.34332915849746 3245 41912 YDL195W SEC31 SGTC_1750 st081859 2.357 µM -0.405125636469807 0.337742334422304 no 2218 0.342692581508211 3177 5291695 SGTC_1946 st076057 65.1 µM -0.405772136464506 0.337504113470365 no 2219 0.342455016752369 3125 953009 SGTC_1912 st060209 90.8 µM -0.407755538403164 0.336773680327623 no 2220 0.34172657933159 3167 688787 SGTC_1692 fluoroquinolonic acid 71 µM -0.408389798896859 0.336540229090959 no 2221 0.341493760746679 3236 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2240 6690706 185.951 µM -0.408392582553175 0.33653920465384 no 2222 0.341492739080228 3011 805876 SGTC_449 xestospongin c 11.1929 µM -0.409280949729239 0.336212331081028 no 2223 0.341166747082955 3214 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3291 9121177 71.43 µM -0.409978894853855 0.335955609877093 no 2224 0.340910714786403 3137 17015612 SGTC_751 0833-0568 350 µM -0.41015997570547 0.335889016428581 no 2225 0.340844299541615 3207 6954252 SGTC_667 1498-1044 59 µM -0.410907664320551 0.335614104528416 no 2226 0.340570121127731 3153 6739982 SGTC_446 go6976 132 µM -0.411081654361282 0.33555014407461 no 2227 0.34050633082263 3235 3501 A protein kinase C inhibitor. SGTC_1486 3970-0793 4.53 µM -0.411367305454204 0.335445146251364 no 2228 0.340401611904678 3214 2844330 SGTC_2145 5634607 200 µM -0.412142728663419 0.335160185899029 no 2229 0.340117405910835 3116 308662 SGTC_779 1360-0071 233 µM -0.412316949632568 0.335096174460344 no 2230 0.34005356340675 3310 7566 SGTC_683 panaxydol 45 µM -0.413666215847716 0.334600595781326 no 2231 0.339559286174087 3139 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3230 9131665 49.47 µM -0.416764206798512 0.333463810289482 no 2232 0.338425442750888 3143 15943720 SGTC_2522 biochanin a 4.94 µM -0.416850383847098 0.333432210032995 no 2233 0.338393923415154 3258 5280373 A possible chelator. SGTC_1812 st052057 4.327 µM -0.416926217490601 0.333404403576768 no 2234 0.338366188126006 3106 3645418 SGTC_2928 9011484 9.79 µM -0.418081651348737 0.332980845814081 no 2235 0.337943709929142 3251 2994751 SGTC_1065 prochlorperazine maleate 2.48 µM -0.418119038411411 0.332967144057639 no 2236 0.337930042955433 3225 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3128 9127691 49.47 µM -0.420135315343074 0.332228541762743 no 2237 0.337193302609006 3232 41316314 SGTC_2480 5767542 37.17 µM -0.420327807419662 0.332158062098784 no 2238 0.337122999278365 3155 2867358 SGTC_888 0916-0002 6.97 µM -0.422516233819237 0.33135720258276 no 2239 0.336324127010103 3296 2802138 YIL048W NEO1 SGTC_2104 5389443 200 µM -0.422691365065119 0.331293146166893 no 2240 0.336260228237737 3311 2244536 SGTC_2106 5357045 167.29 µM -0.422739398192769 0.33127557831974 no 2241 0.336242703591404 3224 668842 SGTC_595 3909-8003 73.7 µM -0.423036145070037 0.331167053047437 no 2242 0.336134444868968 3261 699517 SGTC_844 0330-0132 15.3 µM -0.423055784106478 0.33115987122512 no 2243 0.336127280666373 3264 2828079 SGTC_2264 7948757 110.76 µM -0.423360730806804 0.331048362879121 no 2244 0.336016045579962 3077 2971411 SGTC_1219 1469-0211 33.1 µM -0.423816707856157 0.330881655970672 no 2245 0.335849746103839 3249 6822282 SGTC_2196 6573537 42.6665 µM -0.424256120155763 0.330721036920695 no 2246 0.335689518364932 3270 2903087 SGTC_1672 st016598 6.51 µM -0.424504327288577 0.330630323159183 no 2247 0.335599025067352 3162 4665860 YNL267W PIK1 SGTC_2294 7971431 200 µM -0.424506110459315 0.330629671488977 no 2248 0.335598374979508 3244 5741572 SGTC_2888 9058547 12.99 µM -0.426233203933489 0.329998736378533 no 2249 0.334968962448287 3125 16476514 SGTC_2828 7998861 71.43 µM -0.426326189983345 0.329964780768301 no 2250 0.334935088245097 3237 2988188 SGTC_1439 4092-1168 46 µM -0.426787894816906 0.329796201289979 no 2251 0.334766912118504 3223 2886240 SGTC_793 0488-0545 106 µM -0.4273640854691 0.329585868791161 no 2252 0.33455708098016 3131 292548 SGTC_1735 st034310 56.75 µM -0.428203258668424 0.329279633623207 no 2253 0.334251572013677 3311 871153 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.428565537811159 0.329147464327255 no 2254 0.334119714764312 3185 364106 SGTC_3028 9087778 49.47 µM -0.428866540993627 0.329037666409815 no 2255 0.334010175443368 3145 17217395 SGTC_1276 0871-0068 94.2 µM -0.430311025923283 0.328510962258712 no 2256 0.333484703803268 3213 3414906 SGTC_1423 4048-0112 5.59 µM -0.431310917957531 0.32814656990609 no 2257 0.333121156401041 3246 X1423 SGTC_3318 9139014 38.6185 µM -0.431434949644307 0.328101380218207 no 2258 0.333076071056735 3159 16643984 SGTC_2179 6298986 200 µM -0.431920716435975 0.327924420238909 no 2259 0.33289951874094 3267 738374 SGTC_2650 prasterone 100 µM -0.433952285445565 0.327184758934033 no 2260 0.33216154517551 3224 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_794 k038-0031 316 µM -0.434927314764759 0.326830007237451 no 2261 0.331807593637242 3290 6624242 SGTC_2493 resveratrol 26.09 µM -0.437840354670728 0.325771068757781 no 2262 0.330751007662083 3181 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3336 9143619 71.43 µM -0.440285322816127 0.324883365461547 no 2263 0.329865234803093 3311 45595730 SGTC_1389 3405-0187 19 µM -0.440339672508475 0.324863643794062 no 2264 0.329845555590666 3208 799890 SGTC_684 1140-0066 328 µM -0.44057476732668 0.324778341479985 no 2265 0.329760436691044 3251 6813534 SGTC_269 exalamide 29 µM -0.441107466895788 0.324585089613936 no 2266 0.329567599046087 3180 3316 A derivative of salicylamide. SGTC_1495 4469-0029 237 µM -0.442714136710576 0.324002510751622 no 2267 0.328986257943849 3210 793680 SGTC_1846 st056244 14.8 µM -0.443010177331309 0.323895213310325 no 2268 0.328879186672948 3224 5393182 SGTC_1877 wortmannin 25 µM -0.445821108212787 0.322877145064385 no 2269 0.327863236532226 3314 312145 A covalent inhibitor of PI 3-kinase. SGTC_1572 epiandrosterone 68.9 µM -0.446272239290329 0.322713876836126 no 2270 0.327700303287191 3193 441302 A steroid. SGTC_2058 5236698 133 µM -0.446515668226362 0.322625791996461 no 2271 0.327612398634057 3196 766665 SGTC_1792 st045773 43.6 µM -0.447040090804373 0.322436063340109 no 2272 0.327423056800099 3153 2919270 SGTC_2665 lovastatin 100 µM -0.447251011537396 0.32235976824346 no 2273 0.327346916759561 3240 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2951 9072950 58.06 µM -0.450303996798942 0.321256269422951 no 2274 0.326245628743241 3286 16488155 SGTC_2664 lyso-paf C-16 73.48 µM -0.451108349781588 0.32096579868643 no 2275 0.325955730022266 3186 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2647 atorvastatin 60.16 µM -0.451550233139711 0.32080627084176 no 2276 0.32579651456736 3241 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2068 5226020 147 µM -0.453618536854606 0.320060016186777 no 2277 0.325051704605414 3230 1810509 SGTC_1087 pterostilbene 9.05 µM -0.453961535484834 0.31993633075013 no 2278 0.324928255963073 3311 5281727 Similar to reservatol, lowers cholesterol. SGTC_2109 5483026 200 µM -0.454329577313726 0.319803636985559 no 2279 0.324795815399723 3233 759335 SGTC_1358 1509-0022 2.48 µM -0.454666479870409 0.31968219038405 no 2280 0.324674599776079 3269 3258434 SGTC_2977 9011197 71.43 µM -0.454714278682152 0.319664961438599 no 2281 0.324657403539154 3362 2704722 SGTC_2045 5106652 78.05 µM -0.455865359263018 0.319250175324317 no 2282 0.324243400452653 3292 673349 SGTC_1984 st072354 53.1 µM -0.45669624838885 0.318950909089353 no 2283 0.323944693882317 3137 5762938 SGTC_1223 0764-0573 147 µM -0.456731174346121 0.318938332184154 no 2284 0.323932140400361 3228 1609797 SGTC_345 1362-0200 395 µM -0.457724281900663 0.318580799509563 no 2285 0.323575270315528 3218 1419823 SGTC_1973 st070275 50.2 µM -0.458359582965833 0.318352170730793 no 2286 0.323347061914177 3273 17118334 SGTC_3156 9099931 49.47 µM -0.459609052807042 0.317902720001115 no 2287 0.322898430015507 3157 18111053 SGTC_2474 5321570 43.32 µM -0.459648710931947 0.317888458838866 no 2288 0.322884194670529 3277 2841384 SGTC_1663 st014140 55.4 µM -0.460645603770219 0.317530062423017 no 2289 0.322526443743056 3302 4207120 SGTC_1779 st039427 55 µM -0.460649025947624 0.317528832398369 no 2290 0.322525215922724 3401 1124498 SGTC_3316 9136639 10.545 µM -0.461245939065785 0.317314316243495 no 2291 0.32231108304712 3303 4903665 SGTC_130 0136-0219 337.655 µM -0.461455258139775 0.3172391065509 no 2292 0.322236007189633 3211 234244 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.46184351227389 0.317099624321132 no 2293 0.32209677242057 3257 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_168 3970-0862 530.542 µM -0.462569112950038 0.316839018330365 no 2294 0.321836626178475 3288 3135186 SGTC_2551 apiole 73.87 µM -0.463661181205177 0.316446963523965 no 2295 0.321445256623463 3227 10659 A possible DNA adduct former. SGTC_1301 naphtanilide LB 4.81 µM -0.46397172656725 0.316335514716777 no 2296 0.321334001208184 3345 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2215 7188065 200 µM -0.464609486586835 0.316106687120631 no 2297 0.321105568736583 3330 940217 SGTC_1220 1838-0075 193 µM -0.464678205745345 0.316082034963314 no 2298 0.32108095899049 3229 5529645 SGTC_3335 9143315 29.6265 µM -0.464880069984807 0.316009623366565 no 2299 0.321008671793513 3221 4899691 SGTC_1141 3253-0389 52.6 µM -0.467090830684476 0.315217054242464 no 2300 0.320217447067825 3293 5402031 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.467173975497716 0.315187262955863 no 2301 0.320187705699461 3240 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_833 3852-0053 558 µM -0.468475621074373 0.314721032307668 no 2302 0.319722250448082 3387 3123681 SGTC_328 k915-0120 63.5 µM -0.468956392266483 0.314548901623951 no 2303 0.319550403270974 3307 6624543 SGTC_3086 9117350 49.47 µM -0.472102049859102 0.313423656578287 no 2304 0.318426974702016 3264 2679265 SGTC_1154 4088-0362 150 µM -0.472940483432003 0.313124029651147 no 2305 0.318127820661288 3266 6618304 SGTC_800 3448-7362 155 µM -0.473575902806427 0.312897035072705 no 2306 0.31790118130662 3342 15991913 SGTC_3145 9085516 49.47 µM -0.475312989407036 0.312276847601102 no 2307 0.317281951025579 3295 25236195 SGTC_417 st075190 100 µM -0.475848039566418 0.312085927032714 no 2308 0.317091321184466 3367 222757 SGTC_2519 cryptotanshinone 88.04 µM -0.476066222466232 0.312008087872823 no 2309 0.317013600022817 3366 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3284 9108171 64.8615 µM -0.476189724987805 0.311964030704041 no 2310 0.316969609504581 3281 8687505 SGTC_785 1270-0111 65.3 µM -0.476936353300363 0.311697742601014 no 2311 0.316703722141654 3221 6741994 SGTC_1454 4239-0054 42.6 µM -0.478785912637205 0.311038513703023 no 2312 0.316045469758372 3410 1340767 SGTC_1966 st070145 16.1 µM -0.479762874133247 0.310690544728417 no 2313 0.315698007272465 3184 3748532 SGTC_1507 4075-3230 155 µM -0.480317699372243 0.310493005353575 no 2314 0.315500752668949 3301 659771 SGTC_3075 9116269 49.47 µM -0.481178605621123 0.31018659741056 no 2315 0.31519478248407 3399 17015205 YNL244C SUI1 SGTC_195 4234-0266 16.654 µM -0.481197976685969 0.310179704506511 no 2316 0.315187899372376 3251 2303354 SGTC_125 0133-0007 11.75 µM -0.481621659492725 0.310028959993904 no 2317 0.315037368404059 3389 26541 SGTC_339 3091-4833 71.4 µM -0.482782949179018 0.309615941876154 no 2318 0.314624929386941 3313 3240077 SGTC_2117 5521686 200 µM -0.482783862206219 0.309615617248224 no 2319 0.31462460521073 3223 803312 SGTC_1028 k015-0029 4.8 µM -0.482789237224127 0.309613706157089 no 2320 0.314622696778761 3261 4588309 SGTC_1613 st002381 52.1 µM -0.483381606599966 0.309403120390388 no 2321 0.314412402878123 3333 551167 SGTC_2425 5628681 7.85 µM -0.48377098015104 0.309264733190142 no 2322 0.314274206235894 3313 5714958 SGTC_781 4335-2806 94.4 µM -0.48379103888231 0.309257604851792 no 2323 0.314267087686499 3362 845254 SGTC_1333 1482-0047 286 µM -0.487570338546762 0.307915826038757 no 2324 0.312927104770182 3367 3811116 SGTC_137 0438-0332 85.389 µM -0.488192636820297 0.307695134562504 no 2325 0.312706699762317 3369 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_385 1494-0393 12.4 µM -0.490155279954677 0.306999559976632 no 2326 0.312012011538817 3273 3090647 SGTC_3018 9082602 49.47 µM -0.491249887196361 0.306611924759344 no 2327 0.311624859372392 3383 17332089 SGTC_70 0141-0289 43.283 µM -0.492607498799171 0.306131451753793 no 2328 0.311144974248743 3280 352408 SGTC_3125 9127534 49.47 µM -0.492634223328917 0.306121997004525 no 2329 0.311135530947083 3291 1639235 SGTC_1306 1185-0270 9.02 µM -0.494004161537797 0.305637505927221 no 2330 0.310651620235443 3349 1548076 SGTC_184 1494-0393 24.714 µM -0.495009416823638 0.305282204545089 no 2331 0.310296736667976 3216 3090647 SGTC_2750 bromebric acid 70.15 µM -0.495014265053325 0.305280491411816 no 2332 0.310295025533254 3384 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_179 1273-0063 6.77 µM -0.497039628670193 0.30456519788853 no 2333 0.309580553039646 3246 3108139 SGTC_2826 7992541 19.48 µM -0.497045698766589 0.304563055245999 no 2334 0.309578412816179 3361 2985066 SGTC_2183 6420625 130.508 µM -0.497377412228036 0.304445976138384 no 2335 0.309461465525507 3382 2897619 SGTC_2934 9036370 36.88 µM -0.497692430748831 0.304334808100556 no 2336 0.309350421983147 3311 6462800 SGTC_1377 2944-0135 198 µM -0.498264796509681 0.304132870122188 no 2337 0.309148708490817 3330 1894137 SGTC_1488 4013-0813 75.9 µM -0.49993979934042 0.303542250989334 no 2338 0.308558733609845 3282 2910057 SGTC_3159 9100096 49.47 µM -0.500895763052768 0.303205400441392 no 2339 0.308222242269281 3291 25236875 SGTC_43 0570-0105 72.5 µM -0.501364870419643 0.303040163408116 no 2340 0.308057179250623 3322 1114046 YDL195W SEC31 SGTC_1430 4049-0248 69.1 µM -0.501606657258791 0.302955012842981 no 2341 0.307972117796297 3379 22774488 SGTC_2649 anisomycin 9.56 µM -0.503021902684806 0.302456817902677 no 2342 0.307474436538537 3359 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2964 9083345 53.42 µM -0.503900168824248 0.302147835342291 no 2343 0.30716576596494 3294 17741579 SGTC_2571 chrysanthemic acid 100 µM -0.505706358430552 0.301512846081212 no 2344 0.306531401970531 3297 2743 An insecticide. SGTC_1811 st050069 61.5 µM -0.507356165591354 0.300933360386058 no 2345 0.305952468185217 3390 3877702 SGTC_633 0437-0093 97.7 µM -0.509489532350102 0.30018477256756 no 2346 0.305204566839726 3333 2831118 SGTC_1604 st002052 72.4 µM -0.512151556701249 0.299251864147679 no 2347 0.30427247198886 3433 6254834 YHR062C RPP1 SGTC_2084 5306078 60.6385 µM -0.514946330494489 0.298273851533237 no 2348 0.303295262139883 3277 679340 SGTC_2529 gangaleoidin 93.61 µM -0.515093789526082 0.298222289662889 no 2349 0.303243741164161 3289 4565183 SGTC_2331 7980721 200 µM -0.516258129762881 0.297815298478177 no 2350 0.302837067741148 3310 2981221 SGTC_2602 kawain 100 µM -0.518058881328444 0.297186351234933 no 2351 0.302208593966006 3397 5369129 SGTC_2050 5263056 171 µM -0.521115576153658 0.296120133987742 no 2352 0.301143130431448 3413 763468 YGL055W OLE1 SGTC_2017 5132927 60.65 µM -0.522859107861442 0.295512753331687 no 2353 0.300536151528453 3288 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2255 7941087 197.44 µM -0.523044322670983 0.295448265156928 no 2354 0.300471704829996 3439 935561 SGTC_3219 9131112 49.47 µM -0.523333987389225 0.295347422546567 no 2355 0.300370926623343 3379 17612988 YMR079W SEC14 SGTC_2372 9071633 200 µM -0.523726783329065 0.295210701588182 no 2356 0.300234292097051 3423 21321366 SGTC_802 4112-3352 742 µM -0.523890428669917 0.295153749955313 no 2357 0.300177376166956 3437 704594 SGTC_2310 7668677 200 µM -0.525461403428759 0.294607278998284 no 2358 0.299631238787391 3489 2197143 SGTC_2753 fluvastatin 17.09 µM -0.52575312953752 0.294505852109286 no 2359 0.299529872015575 3355 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1167 k781-0610 148 µM -0.527224455142104 0.293994549640566 no 2360 0.299018864027351 3343 4525169 SGTC_1743 st037606 46.3785 µM -0.52737170106036 0.293943402600373 no 2361 0.298967745656682 3337 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_928 2764-0428 58.7 µM -0.52768200775148 0.293835628579538 no 2362 0.298860031576863 3398 662578 SGTC_3026 9090633 49.47 µM -0.528489139580751 0.293555385617848 no 2363 0.298579941494878 3320 25236842 SGTC_178 4092-0806 87.505 µM -0.528567933172847 0.293528034451888 no 2364 0.298552605018683 3411 2169044 SGTC_2326 6164455 177.58 µM -0.528834993600969 0.29343534008293 no 2365 0.298459960128322 3358 2888790 SGTC_2584 androsterone 48.74 µM -0.529298327121808 0.293274553198086 no 2366 0.29829925794854 3424 2754130 A steroid. SGTC_686 1319-0111 510 µM -0.529405617564414 0.293237326887219 no 2367 0.298262051046413 3474 4562600 SGTC_15 0266-0086 27.098 µM -0.529678457409325 0.293142670161649 no 2368 0.298167443328807 3453 1712902 YIL048W NEO1 SGTC_1633 st005664 67.9 µM -0.530321310377444 0.292919700284644 no 2369 0.297944586944241 3323 2063822 SGTC_2175 5807670 165.306 µM -0.530768002129017 0.292764814165686 no 2370 0.297789778051273 3395 241186 SGTC_1114 scopoletin 1.73284 µM -0.53265655885276 0.292110395729217 no 2371 0.297135671301761 3444 5280460 A coumarin with genotoxic properties. SGTC_340 k038-0059 454 µM -0.533004992558431 0.291989731694336 no 2372 0.297015062154437 3391 23733424 SGTC_2213 7173844 200 µM -0.534418652680002 0.291500413586184 no 2373 0.296525958370832 3342 892728 SGTC_1121 fusaric acid 630.51 nM -0.53594543362315 0.290972370315777 no 2374 0.295998131503549 3303 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_367 0335-0881 7.1 µM -0.536305527645154 0.290847895531694 no 2375 0.295873705477997 3438 23828853 SGTC_603 3794-0023 45.9 µM -0.536602232325852 0.290745351440223 no 2376 0.295771200907835 3416 3802260 SGTC_1934 st074720 32.6 µM -0.539136386275806 0.289870212235891 no 2377 0.294896375185146 3375 17250992 SGTC_1339 1486-1321 22.7 µM -0.53983728192509 0.289628384755899 no 2378 0.294654626801959 3364 3469382 SGTC_1366 1683-0113 21.9 µM -0.539993875229094 0.289574368882988 no 2379 0.294600628150454 3362 708623 SGTC_638 3970-0837 4.09 µM -0.541300871966166 0.289123713194577 no 2380 0.294150109785354 3374 4118451 YLR208W SEC13 SGTC_1505 k297-0037 20.6 µM -0.541315897099761 0.289118534409592 no 2381 0.29414493251243 3324 4089396 SGTC_2234 tolnaftate 200 µM -0.543982152399897 0.288200234838537 no 2382 0.293226877299673 3377 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2600 tangeritin 87.95 µM -0.544248191802231 0.288108682297685 no 2383 0.293135346526795 3393 68077 A bioactive flavone. SGTC_2265 7929201 200 µM -0.545481992681524 0.287684272050634 no 2384 0.29271103103317 3321 1265108 SGTC_3270 9137563 49.47 µM -0.546479346983837 0.287341412205357 no 2385 0.292368240329672 3397 17015724 SGTC_2567 aureobasidin a 60 nM -0.547078239635336 0.287135624204695 no 2386 0.292162490646207 3492 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_364 0083-0097 67.7 µM -0.547379553238711 0.287032114972073 no 2387 0.292058999783514 3458 5207356 SGTC_3326 9140064 16.379 µM -0.549435687903603 0.286326250238516 no 2388 0.291353244179657 3364 1868434 SGTC_2886 9058944 51.95 µM -0.55012281942532 0.286090543941037 no 2389 0.291117568043853 3292 4949929 SGTC_1213 1315-0166 115 µM -0.55116190625069 0.285734281849404 no 2390 0.290761345562432 3391 768401 SGTC_1949 st076024 69.1 µM -0.552577008399197 0.285249438540155 no 2391 0.29027654458203 3334 2921930 SGTC_146 3448-8650 53.125 µM -0.553234193518197 0.285024406674259 no 2392 0.290051527820439 3389 2891488 YIL048W NEO1 SGTC_1807 st050092 58.9 µM -0.555175182375045 0.28436027225112 no 2393 0.289387421151756 3369 5008496 SGTC_1031 k035-0009 16 µM -0.556252083565523 0.283992115842711 no 2394 0.289019269282856 3481 5180959 SGTC_858 0438-0351 2.77 µM -0.556478079396005 0.283914884407735 no 2395 0.288942037816962 3404 2799119 SGTC_1636 st007707 68.9 µM -0.558496400003106 0.283225593047739 no 2396 0.288252731054421 3517 403051 SGTC_1131 3454-3128 32.3 µM -0.56004335956668 0.282697823640876 no 2397 0.287724931430949 3451 710982 SGTC_711 k292-0785 179 µM -0.560912283949954 0.282401583941699 no 2398 0.287428667754515 3461 4146315 SGTC_382 3229-0966 23.2 µM -0.561880501311623 0.282071668582953 no 2399 0.287098719745218 3520 5722370 SGTC_2595 hexamethylquercetagetin 100 µM -0.563985319000948 0.281355103126617 no 2400 0.286382061741891 3379 386331 SGTC_1024 4507-0395 26 µM -0.565052861238081 0.280992004500056 no 2401 0.286018904888621 3517 4201836 SGTC_2260 7964312 200 µM -0.566813512241475 0.28039365687284 no 2402 0.285420444642059 3519 231951 SGTC_1108 betulinic acid 729.144 nM -0.567362944441447 0.280207061715658 no 2403 0.285233810113802 3416 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_307 1501-1223 22.3 µM -0.567528837538975 0.28015073383635 no 2404 0.285177469951877 3455 2830329 SGTC_2289 7946404 165.07 µM -0.567859223889859 0.280038569732904 no 2405 0.285065280841 3442 1246120 YPR165W RHO1 SGTC_2060 5238662 140 µM -0.568095454948613 0.279958384112418 no 2406 0.284985076894271 3414 790130 SGTC_378 3970-0959 8.33 µM -0.568256872234303 0.279903599476349 no 2407 0.284930279522185 3466 6615653 SGTC_2040 5100729 123 µM -0.569962636308251 0.279324985257434 no 2408 0.284351520117554 3414 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2115 tiliquinol 12.7705 µM -0.570319001260933 0.27920417571607 no 2409 0.28423067779936 3411 71208 A bioactive hydroxyquinoline. SGTC_108 0509-0257 621.132 µM -0.570686109651057 0.279079750657362 no 2410 0.284106218092293 3424 536624 SGTC_692 k241-0027 77.8 µM -0.572701984827867 0.278396985467092 no 2411 0.283423246666757 3543 3600480 SGTC_1275 0867-0008 21.1 µM -0.573187119677443 0.278232794722373 no 2412 0.283259002256826 3376 3422836 SGTC_79 0052-0007 94.094 µM -0.574264603451066 0.277868296298814 no 2413 0.282894379048361 3534 2801472 SGTC_1714 st033236 13.627 µM -0.574487964338884 0.277792765462097 no 2414 0.28281882137864 3547 2916566 SGTC_2544 sphondin 68.51 µM -0.575424366524322 0.277476224547028 no 2415 0.282502164363885 3519 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_133 0724-0033 378.92 µM -0.575622760620818 0.277409182148157 no 2416 0.282435096619524 3368 280309 SGTC_2083 5306046 65.942 µM -0.575797755915578 0.277350053372024 no 2417 0.282375945270223 3463 539837 SGTC_185 k048-0037 25.491 µM -0.577615519119597 0.276736218091264 no 2418 0.281761863486533 3510 6827589 SGTC_1397 3532-0190 20.1 µM -0.578339583567177 0.276491896331889 no 2419 0.281517437431019 3395 5322280 SGTC_1380 2291-0730 164 µM -0.579068517121877 0.276246038466316 no 2420 0.281271471054649 3423 2999191 SGTC_119 0121-0043 24.815 µM -0.581924956390986 0.275283641386925 no 2421 0.28030861480418 3554 1092378 SGTC_1267 0828-0272 9.49 µM -0.582025598348465 0.275249763022999 no 2422 0.280274719275855 3548 745334 SGTC_1280 0880-0253 10.1 µM -0.58279613526631 0.274990450863137 no 2423 0.280015273478003 3440 6836607 SGTC_153 4077-0274 519.67 µM -0.58286186613069 0.274968335740506 no 2424 0.279993146773286 3607 3121976 SGTC_1201 1889-3372 45.9 µM -0.58355519087005 0.274735120296401 no 2425 0.279759807419375 3421 5392199 SGTC_2398 5228213 48.84 µM -0.584011716609317 0.274581610818048 no 2426 0.279606214613476 3543 80771 YMR134W ERG29 SGTC_525 k781-2675 26.7 µM -0.584112945599723 0.274547577703927 no 2427 0.27957216283558 3532 3651118 YDL195W SEC31 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.584258931156179 0.274498501129318 no 2428 0.279523059225883 3398 688803 SGTC_1679 SEC14.276 6.7 µM -0.584315096554909 0.274479620925638 no 2429 0.279504168583343 3471 1005053 YMR079W SEC14 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.587174275850097 0.27351934488291 no 2430 0.278543333555323 3430 6708784 An antioxidant flavonoid SGTC_3262 9137218 49.47 µM -0.587583420001233 0.273382066983487 no 2431 0.27840597124328 3392 17650664 SGTC_1803 st050068 52.4 µM -0.588341652914503 0.273127751473791 no 2432 0.278151496372672 3571 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1067 clotrimazole 1.36 µM -0.588498539018856 0.273075145649888 no 2433 0.27809885710086 3472 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3020 9089140 49.47 µM -0.590875798856999 0.272278636570554 no 2434 0.277301821290308 3520 17217859 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.591967433959072 0.27191326763225 no 2435 0.276936197973204 3551 368090 SGTC_213 1246-0773 967 nM -0.592323236259364 0.271794233759812 no 2436 0.276817079490022 3460 6251622 SGTC_801 0866-0028 10.1 µM -0.592658410141371 0.271682124861857 no 2437 0.276704890122621 3522 6849771 SGTC_2345 9052315 157.45 µM -0.593440714495262 0.271420549446382 no 2438 0.276443124005391 3491 6469265 SGTC_1688 st021091 57.6 µM -0.594765285142716 0.270977945278872 no 2439 0.276000187744738 3524 3656366 SGTC_2431 5490079 200 µM -0.594794426604424 0.270968211733645 no 2440 0.275990446763172 3452 5722345 SGTC_3133 9127736 49.47 µM -0.594842915157888 0.270952016449183 no 2441 0.275974239092959 3526 27243420 SGTC_319 1348-1596 45.5 µM -0.596267581646058 0.270476390346706 no 2442 0.275498242161739 3557 5380505 SGTC_1703 st026983 48.3 µM -0.59628361556342 0.270471039784904 no 2443 0.275492887350329 3543 1104023 SGTC_1091 telmisartan 47.6 µM -0.596389381636221 0.270435746684114 no 2444 0.275457566175001 3565 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1326 1431-2094 10.8 µM -0.598926459698966 0.269589838988944 no 2445 0.274610962957853 3471 616278 SGTC_102 gallobenzophenone 83.616 µM -0.599509163718012 0.269395742314186 no 2446 0.274416700555187 3580 70837 SGTC_1570 verbenone 133 µM -0.600001121148007 0.269231927572912 no 2447 0.2742527441561 3555 29025 A natural terpanoid with antifungal properties. SGTC_2752 diclazuril 33.15 µM -0.600099166945879 0.269199285706148 no 2448 0.274220073867035 3526 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2217 6934799 96.0675 µM -0.602807443481204 0.268298419136603 no 2449 0.273318397212836 3490 675606 SGTC_839 0122-0028 230 µM -0.603325603904747 0.268126234024393 no 2450 0.273146051617531 3475 759448 SGTC_517 1365-0151 113 µM -0.603581903126618 0.268041086156475 no 2451 0.27306082371744 3561 768657 SGTC_916 4466-0038 42 nM -0.603710404889739 0.267998400354439 no 2452 0.273018097626966 3592 5722064 YGL116W CDC20 SGTC_1970 st070122 35.8 µM -0.604455173433502 0.26775107006202 no 2453 0.272770531695911 3582 102928 SGTC_1689 st020265 53.493 µM -0.605254264710331 0.267485827688607 no 2454 0.272505032446817 3542 5758320 YPR016C TIF6 SGTC_232 clozapine 119 µM -0.605403443429659 0.267436325476524 no 2455 0.272455481815526 3496 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.606859038374794 0.266953555707991 no 2456 0.271972231938615 3459 390807 SGTC_2333 9017922 200 µM -0.608889428970391 0.266280882433069 no 2457 0.271298865759322 3543 3163164 SGTC_1147 3809-1045 12.3 µM -0.610912961131708 0.265611335992508 no 2458 0.270628601880469 3480 325925 SGTC_1071 trifluoperazine 6.31 µM -0.611127343022366 0.265540451352492 no 2459 0.270557639661169 3588 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_990 3985-0011 41.3 µM -0.612787595549221 0.264991819640204 no 2460 0.270008396962863 3473 5399565 YGL099W LSG1 SGTC_3292 9120825 59.784 µM -0.614964853702773 0.264273216957513 no 2461 0.269288965711938 3583 24824900 SGTC_2201 6605497 169.863 µM -0.616667722178037 0.263711878633875 no 2462 0.268726957766252 3520 670741 SGTC_1827 berberine 7.24 µM -0.618632584076632 0.263064932617095 no 2463 0.268079215582443 3442 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2523 spermine 47.74 µM -0.619157741747813 0.262892157843138 no 2464 0.267906223748294 3523 1103 A DNA binding polyamine. SGTC_2356 9061756 188.97 µM -0.619862544435424 0.262660371796624 no 2465 0.267674143564152 3508 20104043 SGTC_1649 st011737 51.3 µM -0.619914403425894 0.262643321238772 no 2466 0.26765707123593 3510 1761035 SGTC_1480 1070-0044 41.2 µM -0.619940306167745 0.262634804968101 no 2467 0.267648544084741 3530 3124987 SGTC_84 0443-0269 128.823 µM -0.620795688416454 0.262353652874693 no 2468 0.267367030229541 3524 6150058 SGTC_3090 9117696 49.47 µM -0.620920597792606 0.262312609823788 no 2469 0.267325933952557 3477 7923821 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.621875510023746 0.261998950961773 no 2470 0.267011864827723 3495 6857784 SGTC_2478 5763493 32.33 µM -0.622246678128919 0.261877085738123 no 2471 0.266889838535133 3532 1365576 YLR208W SEC13 SGTC_919 tnp00227 403.569 nM -0.628320102718388 0.25988714260777 no 2472 0.2648971325624 3560 1269246 A methoxyflavone. YNL221C POP1 SGTC_1188 1403-0014 4.57 µM -0.628413417639759 0.259856629153093 no 2473 0.264866574789115 3574 9614867 SGTC_2476 5806916 10.51 µM -0.628878902866681 0.259704445710912 no 2474 0.264714169427442 3503 2870194 SGTC_1722 st034304 3.6505 µM -0.630012006150189 0.259334186886416 no 2475 0.264343364522878 3545 4036148 YLR033W RSC58 SGTC_135 0933-0004 26.348 µM -0.630547186893503 0.259159403276609 no 2476 0.264168320097236 3543 21230617 YGL099W LSG1 SGTC_715 0868-0130 184 µM -0.631262074966951 0.258926024447046 no 2477 0.263934589977073 3621 2876258 SGTC_1762 st045503 25.4615 µM -0.631456683140689 0.258862512455044 no 2478 0.263870981782679 3551 4645554 SGTC_3188 9110789 49.47 µM -0.632178192733055 0.258627112173473 no 2479 0.263635222690105 3599 849217 SGTC_2032 5185112 25.99 µM -0.632991183010839 0.258361998196759 no 2480 0.263369700369389 3496 5718189 SGTC_2702 st077768 96.8 µM -0.633131683155829 0.2583161957463 no 2481 0.263323826915735 3503 6484119 SGTC_3087 9117406 49.47 µM -0.635041204693085 0.257694117312749 no 2482 0.262700770822286 3562 42546093 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.635590712187609 0.257515244561343 no 2483 0.26252161235822 3544 688664 SGTC_1123 mangostin 811.285 nM -0.637762948879138 0.256808781536574 no 2484 0.261814000793504 3524 5281650 An antioxidant. SGTC_636 0kpi-0074 126 µM -0.638185224860978 0.256671564550079 no 2485 0.261676556997073 3550 616434 SGTC_205 1486-1330 71.903 µM -0.638490170321704 0.256572497417398 no 2486 0.261577325358592 3576 4118834 SGTC_886 0866-0150 153 µM -0.640632578696518 0.255877058574061 no 2487 0.26088071386183 3630 271463 SGTC_3303 9125618 40.5795 µM -0.643089946919864 0.25508059483206 no 2488 0.260082868651321 3583 22695467 SGTC_1687 st020778 55.3625 µM -0.643539747194697 0.254934949476549 no 2489 0.259936966220513 3586 4259299 SGTC_1144 3486-0183 12.5 µM -0.645311861427351 0.254361562519057 no 2490 0.259362553779801 3589 6744069 SGTC_1782 st039423 80.636 µM -0.645776572558076 0.254211312096594 no 2491 0.259212031098101 3520 2068169 SGTC_2743 auranofin 4.32 µM -0.646577571629223 0.253952442326737 no 2492 0.25895268879196 3545 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1172 0370-0043 85 µM -0.647775250478943 0.253565630367594 no 2493 0.258565162595892 3621 376585 SGTC_918 glabranin 770.725 nM -0.64938367570987 0.25304664781952 no 2494 0.25804520638082 3606 124049 Also referred to as licorice root. SGTC_2304 7443016 91.4 µM -0.650679093464353 0.252629068488414 no 2495 0.257626830803939 3559 939854 SGTC_123 0083-0120 66.675 µM -0.651176251045428 0.252468905632165 no 2496 0.257466359508175 3531 16001701 SGTC_2430 5571206 200 µM -0.651507085053592 0.252362354758589 no 2497 0.257359602506055 3639 1731771 SGTC_691 1548-0686 185 µM -0.652458965731614 0.252055917217994 no 2498 0.257052567980882 3567 46495133 SGTC_1767 st044992 70.3 µM -0.65285912131147 0.2519271543581 no 2499 0.256923552426906 3563 9600693 SGTC_2263 7948595 193.29 µM -0.653243088726648 0.251803633203875 no 2500 0.256799787838196 3582 2971371 SGTC_1610 st001799 48.1 µM -0.653344110970007 0.251771139968032 no 2501 0.256767230397784 3536 621897 SGTC_3106 9121286 49.47 µM -0.653935276174177 0.251581039401568 no 2502 0.256576752808598 3640 15943471 SGTC_95 0471-0001 561.058 µM -0.654504695572771 0.251398003339007 no 2503 0.256393351479487 3544 4015405 SGTC_3056 9094900 49.47 µM -0.654551585596172 0.251382933991499 no 2504 0.256378251960994 3540 25236784 SGTC_2167 5876490 200 µM -0.656301462460113 0.250820906400927 no 2505 0.255815088384238 3634 686534 SGTC_976 1348-1067 47.6 µM -0.656422854651408 0.250781942198575 no 2506 0.255776044651143 3646 5310671 YGL099W LSG1 SGTC_1520 flindersine 88 µM -0.657188406954971 0.250536290735273 no 2507 0.255529889465408 3683 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2464 5717415 7.67 µM -0.657779089276875 0.250346838960697 no 2508 0.25534004647476 3519 5285744 SGTC_1076 itraconazole 331 nM -0.65874861234192 0.250036044864938 no 2509 0.255028605429031 3635 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1641 st009299 47.1 µM -0.65897558099783 0.249963316490616 no 2510 0.254955724735963 3569 4046054 SGTC_2906 7926292 26.41 µM -0.659302461512937 0.249858592733872 no 2511 0.254850781032749 3605 2966319 SGTC_1979 st071809 45.3 µM -0.662283983071771 0.248904469159579 no 2512 0.253894619891897 3666 4976333 SGTC_2693 st077581 40.7 µM -0.664097182131141 0.248325172832289 no 2513 0.253314056779529 3635 25238761 SGTC_2385 9074692 200 µM -0.664203450696391 0.248291243554261 no 2514 0.253280052609349 3595 17046906 SGTC_2250 alverine citrate 130 µM -0.664632973946808 0.248154131162891 no 2515 0.253142636783266 3570 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1187 1391-0724 117 µM -0.666513137507094 0.247554421033852 no 2516 0.252541584640555 3656 6997986 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.666580225194449 0.247533036591602 no 2517 0.25252015189845 3630 16623 A steroid. SGTC_19 0279-0214 38.434 µM -0.668581237861978 0.246895660563753 no 2518 0.251881322125473 3680 3566274 YBR002C RER2 SGTC_1003 4049-0218 100 µM -0.6701722664378 0.246389502976104 no 2519 0.251373990552703 3652 295161 SGTC_1624 st003710 6.25 µM -0.671737794438421 0.24589200130147 no 2520 0.25087531808102 3641 24207033 SGTC_1415 3966-0071 78.1 µM -0.672079227895284 0.245783570447949 no 2521 0.250766629825324 3622 2893185 SGTC_287 k060-0039 29.6 µM -0.672213654897168 0.245740886787882 no 2522 0.25072384462047 3660 5861974 SGTC_2919 7978188 46.38 µM -0.673257817474168 0.245409476752077 no 2523 0.250391641949309 3621 2980291 SGTC_503 tyrphostin 8 294 µM -0.673854188059385 0.245220300641749 no 2524 0.250202010039682 3607 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2443 5493264 126.67 µM -0.67422308046695 0.245103322678709 no 2525 0.250084749013062 3629 5340055 SGTC_2151 5563267 85.4165 µM -0.674486614123901 0.245019772980839 no 2526 0.250000996571323 3639 5310824 SGTC_1622 st003707 19.4 µM -0.674490759476595 0.245018458876558 no 2527 0.249999679274407 3660 10140899 SGTC_3014 9081533 49.47 µM -0.675233239602625 0.244783148923964 no 2528 0.249763795736658 3645 21367265 SGTC_2638 epoxomicin 18 µM -0.675789483164246 0.244606941592236 no 2529 0.249587156415693 3629 9915668 A protesome inhibitor. SGTC_3034 9090421 49.47 µM -0.675993014652057 0.244542483781249 no 2530 0.249522540051148 3575 17173761 SGTC_3181 9108277 49.47 µM -0.67715564231206 0.244174458563716 no 2531 0.249153604130653 3603 17097298 SGTC_1260 0700-1617 7.75 µM -0.677338114881349 0.244116724714884 no 2532 0.249095726575832 3641 2853078 SGTC_3195 9113082 49.47 µM -0.678136370976181 0.243864245120103 no 2533 0.248842615852651 3606 17018038 SGTC_2342 7990637 118.86 µM -0.678248745389984 0.243828713651683 no 2534 0.248806995215332 3679 2033102 YER133W GLC7 SGTC_2766 oltipraz 83.91 µM -0.679387486853472 0.243468814653922 no 2535 0.248446188149267 3628 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1196 1588-0294 184 µM -0.680864831888091 0.243002328067062 no 2536 0.2479785113386 3629 6144269 SGTC_883 0850-0245 24.6 µM -0.68184777018082 0.242692223437993 no 2537 0.24766760721373 3683 6823229 YPR165W RHO1 SGTC_3338 9144300 39.5675 µM -0.68297546606533 0.242336713666267 no 2538 0.247311172739491 3638 4901274 SGTC_589 1227-0070 34.1 µM -0.684806165577981 0.241760181149422 no 2539 0.246733122092937 3655 2841384 SGTC_2791 5663188 71.43 µM -0.685335445651357 0.241593636600541 no 2540 0.246566134721858 3629 54690634 SGTC_294 k038-0071 157 µM -0.685659150912864 0.241491809427576 no 2541 0.24646403585706 3651 24152826 SGTC_2251 lansoprazole 556 µM -0.685773751940203 0.241455765250152 no 2542 0.246427895335763 3579 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.686064984367684 0.241364180327055 no 2543 0.246336065207043 3619 77254 SGTC_2502 avocadyne acetate 18.59 µM -0.687083528764312 0.24104402343782 no 2544 0.246015046575389 3629 3952079 SGTC_2817 7995342 71.43 µM -0.687568492928843 0.240891666874302 no 2545 0.245862277428256 3632 18879975 SGTC_1600 coumarin 106 71.1 µM -0.688511167780689 0.24059566565189 no 2546 0.245565470022041 3705 100336 A hepatotoxic, DNA x-linker. SGTC_219 mitoxanthrone 164.414 µM -0.689198837265726 0.240379861444635 no 2547 0.245349074214736 3643 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2434 5670830 169.91 µM -0.689856152892874 0.240173681477355 no 2548 0.245142326003125 3651 1549830 SGTC_887 0885-0007 9.62 µM -0.690044273139355 0.240114691609012 no 2549 0.245083173010373 3685 5719458 SGTC_813 k007-0158 173 µM -0.690942170359858 0.239833242034822 no 2550 0.244800941804911 3675 6523916 SGTC_1637 st007924 17.4 µM -0.691768290114312 0.239574450447033 no 2551 0.24454142663245 3650 683336 SGTC_2149 5554786 194.827 µM -0.692981934517592 0.239194538907721 no 2552 0.244160444376322 3704 745063 YPR165W RHO1 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.693304143849166 0.23909373187503 no 2553 0.244059351540569 3697 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_462 ag-879 158 µM -0.693422339110167 0.239056758900189 no 2554 0.244022273563428 3664 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1789 tunicamycin 25 nM -0.693866544919754 0.238917833645391 no 2555 0.243882952908455 3649 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1195 1502-0147 41.1 µM -0.694560122403697 0.238701005775047 no 2556 0.243665505212675 3675 817940 SGTC_1492 4158-0558 28.5 µM -0.697461618241434 0.23779510157539 no 2557 0.24275697566649 3665 3967268 SGTC_1578 josamycin 24.2 µM -0.699375438703014 0.237198602719688 no 2558 0.242158716569273 3617 5282165 A P450 substrate. SGTC_2229 7354935 190 µM -0.699376084322473 0.237198401632038 no 2559 0.242158514883986 3612 318112 SGTC_3290 9121031 71.43 µM -0.700780232550446 0.236761280725496 no 2560 0.24172008808386 3670 17014854 SGTC_3246 9135460 32.98 µM -0.701491584285566 0.236540001268634 no 2561 0.241498142399403 3605 41446951 SGTC_2329 6138490 200 µM -0.70150487044775 0.236535869438656 no 2562 0.241493998096314 3693 720019 SGTC_3324 9138759 60.749 µM -0.702471326759715 0.236235420178792 no 2563 0.241192638598471 3698 45595710 SGTC_1428 4049-0204 61.7 µM -0.703410992478793 0.235943501131862 no 2564 0.240899829016971 3717 X1428 SGTC_1388 3346-4487 254 µM -0.703469494464579 0.235925333326119 no 2565 0.240881605587907 3729 3345614 SGTC_145 3737-0113 38.366 µM -0.704625248182192 0.235566571858087 no 2566 0.240521740909425 3705 6849351 SGTC_1887 st057648 70.8 µM -0.704814664287676 0.23550780327478 no 2567 0.24046279073599 3677 688672 SGTC_432 NS 1619 61.3 µM -0.705585347503731 0.235268773145127 no 2568 0.240223019485659 3710 4552 A K+/calcium channel activator. SGTC_696 1560-0013 611 µM -0.70660421863881 0.234952972350626 no 2569 0.239906233289312 3728 1650269 SGTC_738 1315-0003 72.4 µM -0.707077870793467 0.234806242874348 no 2570 0.239759043544977 3687 6251474 SGTC_1736 st036774 51 µM -0.707567462130033 0.234654628960512 no 2571 0.239606952424101 3731 1272247 SGTC_2004 4023728 41.89 µM -0.707635835239092 0.234633459866427 no 2572 0.239585716569137 3671 360084 YDR527W RBA50 SGTC_1990 st072050 59.8 µM -0.707915470150879 0.234546892703113 no 2573 0.239498876065569 3701 17233948 SGTC_350 k064-0020 19.8 µM -0.708061976082449 0.234501545609678 no 2574 0.239453385572232 3670 2790705 SGTC_147 4466-0538 29.23 µM -0.710054169795766 0.233885395590558 no 2575 0.238835272510676 3760 6742687 YHR072W ERG7 SGTC_2898 9056270 58.44 µM -0.71011573506795 0.233866368848601 no 2576 0.238816184716256 3636 19154699 SGTC_1005 4092-0690 4.4 µM -0.710884691976479 0.23362879505488 no 2577 0.238577846412173 3702 1529343 SGTC_250 brefeldin a 552.239 µM -0.711710088706587 0.233373932820001 no 2578 0.238322159519672 3594 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_593 1203-0218 61.7 µM -0.712641891783481 0.233086400380401 no 2579 0.238033691096014 3720 3666956 SGTC_1684 st024538 14.6195 µM -0.713641202443162 0.232778255407579 no 2580 0.237724536422189 3684 6732859 SGTC_2627 acetyl isogambogic acid 100 µM -0.714187153687628 0.232610002892609 no 2581 0.237555729699151 3684 6857789 A caspase activator and apoptosis inducer. SGTC_1927 st060202 13.8 µM -0.714855967537841 0.232403978469268 no 2582 0.237349023863659 3659 688887 SGTC_2237 6667747 47.222 µM -0.714935983770904 0.232379336709014 no 2583 0.237324300396845 3652 729940 YDL015C TSC13 SGTC_2890 9046729 58.44 µM -0.715277726518782 0.23227411013878 no 2584 0.237218724424358 3642 903329 SGTC_2673 kobusone 100 µM -0.715589709309075 0.23217807015976 no 2585 0.237122364847216 3748 6710676 An epoxy ketone and protein crosslinker. SGTC_25 0118-0223 35.662 µM -0.715964750862454 0.232062647591398 no 2586 0.237006557296105 3726 5333628 SGTC_2435 5706476 10.6 µM -0.717737496163415 0.231517501108971 no 2587 0.236459579462529 3701 5725375 SGTC_2698 st077697 67.5 µM -0.717872970133206 0.231475870161043 no 2588 0.236417807773794 3670 3154499 SGTC_171 k064-0041 9.68 µM -0.719346254879998 0.231023401564917 no 2589 0.235963801396869 3686 53325 SGTC_727 3032-0951 202 µM -0.720549994615691 0.230654081182768 no 2590 0.235593214772014 3692 3652836 SGTC_3232 9132874 49.47 µM -0.72081743037203 0.230572073804931 no 2591 0.235510924875757 3702 3784940 SGTC_958 1222-0007 33 µM -0.722564571280358 0.23003672589866 no 2592 0.234973720602281 3764 7312461 SGTC_536 3852-0578 10.6 µM -0.723017739507109 0.229897982636583 no 2593 0.234834492814398 3707 2869208 SGTC_2444 5485484 36.41 µM -0.723881827820122 0.229633560784423 no 2594 0.234569143630171 3785 6790631 SGTC_2203 7227154 166.4 µM -0.724860192195505 0.229334374782898 no 2595 0.234268902193352 3722 896304 SGTC_3235 9132602 49.47 µM -0.726666582105635 0.228782551353464 no 2596 0.233715114846205 3730 4912240 SGTC_464 bw-b 70c 158 µM -0.72736473337214 0.228569477109319 no 2597 0.233501276279877 3741 5353454 SGTC_1497 4476-2978 41.3 µM -0.72806330227769 0.228356387009922 no 2598 0.233287418453164 3735 1528379 SGTC_884 0851-0618 334 µM -0.728381859332497 0.228259252061327 no 2599 0.233189932431892 3753 9642473 SGTC_803 4488-1585 147 µM -0.728494585044515 0.22822488511343 no 2600 0.233155441105432 3707 747204 SGTC_2800 7887935 81.82 µM -0.728500951628556 0.228222944205051 no 2601 0.233153493170045 3706 2961002 SGTC_1183 1254-0324 198 µM -0.729014946653732 0.228066278980683 no 2602 0.232996259825303 3762 5799357 SGTC_1132 3456-3614 2.5 µM -0.731027923001885 0.227453308195886 no 2603 0.232381048752766 3799 3125502 SGTC_2377 9073351 62.6 µM -0.734022470005098 0.226543159010386 no 2604 0.231467521727226 3713 7337946 YHR072W ERG7 SGTC_3312 9133330 71.43 µM -0.73559770400982 0.226065215906147 no 2605 0.230987780138605 3773 17617324 SGTC_1472 k841-0093 193 µM -0.735734409658491 0.22602376482157 no 2606 0.230946172271712 3812 X1472 SGTC_2018 5133068 143 µM -0.736124997160325 0.225905356848289 no 2607 0.230827315731636 3735 785362 SGTC_3308 9128332 17.569 µM -0.736197047560961 0.225883518348746 no 2608 0.230805394386536 3712 17332805 YDL196W YDL196W SGTC_2001 4023502 57.655 µM -0.736364878529945 0.225832653357653 no 2609 0.230754336298081 3750 108941 YCR052W RSC6 SGTC_1242 0402-0103 60.1 µM -0.737730188594898 0.22541910587266 no 2610 0.230339211690834 3697 432868 SGTC_2685 mycophenolic acid 18.85 µM -0.737855142958298 0.225381279073867 no 2611 0.230301239995008 3726 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1146 3579-1023 7 µM -0.737987079238048 0.225341342576104 no 2612 0.230261150402578 3812 X1146 SGTC_3314 9135860 59.4275 µM -0.738320601853019 0.225240404702997 no 2613 0.230159825056037 3701 25252478 SGTC_2938 9059746 27.26 µM -0.738924716470048 0.225057639605705 no 2614 0.229976356428313 3725 6471769 SGTC_1777 st045864 34.765 µM -0.739146861747103 0.224990454286164 no 2615 0.22990891185759 3734 4691462 SGTC_1723 st034307 2.5525 µM -0.740115470038202 0.224697642562923 no 2616 0.229614966289361 3796 867466 SGTC_2807 7945238 51.95 µM -0.741129106758329 0.224391450244727 no 2617 0.229307581417645 3777 17148797 SGTC_1212 0520-0165 585 µM -0.741483510889975 0.2242844502156 no 2618 0.229200162982204 3846 5403258 SGTC_3032 9089427 49.47 µM -0.74174840943332 0.224204492213873 no 2619 0.229119891754503 3714 17173707 SGTC_983 1491-0821 12.2 µM -0.741878842064557 0.224165127871558 no 2620 0.229080373030043 3720 46495113 SGTC_1830 st055982 50.3 µM -0.742154056167387 0.224082081611183 no 2621 0.228997000689142 3666 455313 An antimicrobial agent. SGTC_1953 st076800 12.1 µM -0.743617770477768 0.223640697408716 no 2622 0.228553874660339 3774 297591 SGTC_2781 5567276 71.43 µM -0.744688577812585 0.223318107990722 no 2623 0.228230002900768 3781 2853274 SGTC_3174 9107204 49.47 µM -0.746707837238638 0.222710510753929 no 2624 0.227619968966584 3751 3938802 SGTC_680 0417-1641 114 µM -0.746748235379508 0.222698364533164 no 2625 0.227607773749257 3741 2835990 SGTC_1835 st008666 49.2 µM -0.747900000249129 0.222352230475684 no 2626 0.227260238711483 3690 690455 SGTC_1821 st053465 65.6 µM -0.748643129950434 0.222129064455928 no 2627 0.227036164593064 3735 675086 SGTC_311 1315-0136 58 µM -0.748925928462709 0.222044172069278 no 2628 0.226950925769724 3782 6759207 SGTC_173 1273-0061 2.693 µM -0.749480078599292 0.221877877218229 no 2629 0.226783950695417 3737 2847414 YPL266W DIM1 SGTC_2819 7996655 46.38 µM -0.749797471520953 0.221782662858075 no 2630 0.2266883459148 3684 6456960 SGTC_2780 5215298 71.43 µM -0.750645873317968 0.22152826633244 no 2631 0.22643290285788 3744 2834131 SGTC_2172 5754775 163.918 µM -0.751311773126598 0.221328710617066 no 2632 0.226232522753647 3729 2263357 SGTC_1466 k213-0079 57.5 µM -0.751554515994084 0.221255991426011 no 2633 0.22615950239375 3715 3657981 SGTC_3021 9087658 49.47 µM -0.752319271473203 0.221026980759867 no 2634 0.225929540628349 3713 25237042 SGTC_2940 9060638 45.86 µM -0.752770069476806 0.220892050140192 no 2635 0.225794047750602 3770 4027022 SGTC_352 k048-0007 5.11 µM -0.75298996719351 0.220826248563505 no 2636 0.22572797147147 3774 6811911 SGTC_2846 9008642 19.48 µM -0.753016406453672 0.2208183377093 no 2637 0.225720027569394 3803 2992898 SGTC_1103 duloxetine 36.1 µM -0.754387011967198 0.220408463049791 no 2638 0.225308434073591 3858 60835 A selective serotonin reuptake inhibitor. SGTC_233 rapamycin 362 pM -0.754956699325781 0.220238228466488 no 2639 0.225137481807348 3764 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_356 1634-0012 32.5 µM -0.755445043939821 0.220092360842264 no 2640 0.22499099745436 3738 735457 SGTC_2101 5377231 179.231 µM -0.758033918603969 0.219319995039708 no 2641 0.224215338762103 3803 2844213 SGTC_1725 st036284 20.55 µM -0.7599443399606 0.218751039469405 no 2642 0.223643928039326 3825 707914 SGTC_1194 1488-0194 225 µM -0.760250457029284 0.218659951686619 no 2643 0.22355244486724 3725 1391452 SGTC_8 0354-0001 70 µM -0.761129899902971 0.21839838734166 no 2644 0.223289741559402 3797 4993152 SGTC_507 nimesulide 162 µM -0.762924331400142 0.217865245997058 no 2645 0.222754262232385 3796 4495 A COX2 inhibitor. SGTC_2887 9044784 58.44 µM -0.763405080802282 0.217722538718108 no 2646 0.222610925387441 3776 6465546 SGTC_419 nsc-638432 893 µM -0.763406372968347 0.217722155219846 no 2647 0.222610540195205 3754 368090 SGTC_762 1165-0429 115 µM -0.766296797005796 0.216865290453179 no 2648 0.221749861855954 3736 5967793 SGTC_2507 purpurin 79.67 µM -0.766406555237716 0.216832791147081 no 2649 0.221717216778538 3794 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2027 5150920 200 µM -0.766874675637804 0.216694212769439 no 2650 0.221578015897888 3746 786715 SGTC_1413 3910-0535 34.4 µM -0.767373701292928 0.21654654188521 no 2651 0.221429680010786 3789 2876951 SGTC_3237 9133362 49.47 µM -0.767485897680674 0.216513348925655 no 2652 0.221396337338862 3720 43845137 SGTC_1422 4031-0024 15.5 µM -0.767583335244941 0.216484524707706 no 2653 0.221367383043079 3723 782427 SGTC_2015 5119600 184 µM -0.768215546117271 0.216297556496047 no 2654 0.221179569499407 3792 2828786 SGTC_532 1548-0774 215 µM -0.769108629008311 0.216033598110962 no 2655 0.22091441301724 3890 5932993 SGTC_1903 st060211 78.3 µM -0.770520081296081 0.215616811872476 no 2656 0.220495723847246 3825 688960 SGTC_2394 5221648 200 µM -0.7715733393046 0.215306100448743 no 2657 0.220183584898326 3872 788586 SGTC_124 0136-0217 7.121 µM -0.772928567308605 0.214906690268724 no 2658 0.21978232848557 3855 3976905 SGTC_2937 9044753 11.33 µM -0.774554938664741 0.214427937841066 no 2659 0.219301346449314 3795 6465530 YGL099W LSG1 SGTC_3025 9087895 49.47 µM -0.775071466832045 0.214276018100868 no 2660 0.219148715404883 3806 17173641 SGTC_1398 3558-0053 112 µM -0.77558406559828 0.214125315981316 no 2661 0.218997305873053 3705 4532369 SGTC_2210 7115885 190.385 µM -0.776474621361515 0.213863642628914 no 2662 0.218734399912555 3839 2927039 SGTC_57 miconazole 162.5 nM -0.7767410164129 0.213785403561446 no 2663 0.218655791244335 3716 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2903 5923464 63.88 µM -0.777639006952175 0.213521790480903 no 2664 0.218390929272503 3814 2876576 SGTC_1256 0570-0116 285 µM -0.777884350560259 0.213449800650967 no 2665 0.218318597422246 3820 410638 SGTC_2941 9056145 11.23 µM -0.779890153384521 0.212861779746835 no 2666 0.217727767382103 3672 2119517 SGTC_1744 st037937 38.9 µM -0.783287206299792 0.21186805968474 no 2667 0.216729237187298 3849 1016152 SGTC_3190 9110366 49.47 µM -0.783532401082919 0.211796439456142 no 2668 0.216657267218397 3752 17123768 SGTC_2348 9022543 33.42 µM -0.784751158750962 0.211440656414316 no 2669 0.216299740680423 3838 3162678 YDL140C RPO21 SGTC_1892 st058411 7.36 µM -0.785704650033957 0.211162554838149 no 2670 0.216020269184715 3793 3934738 SGTC_1122 capsaicin 818.572 nM -0.786081887738059 0.211052586398765 no 2671 0.215909757323876 3907 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1843 st055809 45.5 µM -0.789258180632189 0.210127998369901 no 2672 0.21498056168725 3856 16413835 SGTC_1292 0kpi-0043 232 µM -0.789542516765892 0.21004534707439 no 2673 0.214897495135241 3838 3333905 SGTC_2730 imipramine 71.33 µM -0.791392096217449 0.209508174697277 no 2674 0.214357610379897 3815 3696 A tricyclic antidepressant. SGTC_214 4373-3496 70 µM -0.791791928213493 0.209392158028323 no 2675 0.214241004819988 3890 3779166 SGTC_2841 9004761 38.96 µM -0.792361194751355 0.209227042877656 no 2676 0.214075049668735 3814 2991039 SGTC_685 1278-0033 54.9 µM -0.792867464598043 0.20908026426173 no 2677 0.213927522471619 3847 3590572 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.792919307251724 0.20906523737455 no 2678 0.213912418847142 3824 641818 YHR062C RPP1 SGTC_708 3448-5400 146 µM -0.794146993039815 0.208709571585186 no 2679 0.213554931411512 3786 3462195 SGTC_198 3454-2873 16.191 µM -0.796151497690531 0.208129625159989 no 2680 0.212971992442649 3814 710957 SGTC_984 1492-0255 2.91 µM -0.796485587284182 0.208033058385939 no 2681 0.212874924705491 3798 1585198 SGTC_2335 9018011 154.17 µM -0.796493954555845 0.208030640211263 no 2682 0.212872493976145 3866 6458208 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.796617530639261 0.20799492816556 no 2683 0.212836596464936 3893 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2641 levomentholum 100 µM -0.796728850846934 0.20796276102372 no 2684 0.212804262177996 3789 16666 SGTC_90 0870-0863 4.608 µM -0.797256005404989 0.207810474074933 no 2685 0.212651182771738 3810 1738164 SGTC_291 SEC14.278 35.5 µM -0.797467453871935 0.207749408335256 no 2686 0.212589798728708 3809 1068044 SGTC_600 1495-0418 41.6 µM -0.797891554350851 0.20762696122995 no 2687 0.21246671244855 3822 5377768 SGTC_668 1682-0499 62.6 µM -0.798944654552532 0.207323092586024 no 2688 0.212161252282367 3848 682214 SGTC_2894 9048625 32.47 µM -0.79939151586678 0.207194231708025 no 2689 0.212031714196521 3843 4092861 SGTC_1200 1643-0193 18.4 µM -0.801651067546968 0.206543373142094 no 2690 0.211377414222519 3809 5403974 SGTC_2307 7538926 6.34 µM -0.802343531343625 0.206344153270679 no 2691 0.211177133983075 3863 96582 SGTC_946 3434-1334 87.4 µM -0.80234910853641 0.206342549190536 no 2692 0.211175521351726 3828 4047976 SGTC_1236 0330-0013 258 µM -0.803514142396692 0.206007630874862 no 2693 0.210838812949898 3836 4617066 SGTC_707 0865-0008 204 µM -0.804519116711767 0.205718984875463 no 2694 0.210548616721256 3833 723043 SGTC_175 3793-3120 23.7 µM -0.807035509301729 0.204997287145447 no 2695 0.209823012672851 3859 5322297 SGTC_1828 st055811 49 µM -0.807535958522067 0.204853938669732 no 2696 0.209678883133963 3868 5877589 SGTC_2466 5983409 37.09 µM -0.807708264547316 0.204804597198173 no 2697 0.20962927241883 3857 2879657 SGTC_552 k242-0005 476 µM -0.810382502273627 0.204039710235773 no 2698 0.208860185644021 3911 4088318 SGTC_1345 1488-0192 31.4 µM -0.813379808488143 0.203184444865094 no 2699 0.208000166138567 3838 658348 SGTC_682 0kpi-0099 17 µM -0.816846124857313 0.202198023048825 no 2700 0.207008184628002 3906 1714895 YML126C ERG13 SGTC_1758 st042942 75.2445 µM -0.817653652667049 0.201968634162819 no 2701 0.206777491065352 3788 669317 SGTC_2606 farnesol 9.78 µM -0.817900194889683 0.201898631655174 no 2702 0.206707089522051 3876 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2953 9074162 66.49 µM -0.819672227865658 0.201395913116157 no 2703 0.206201493116183 3803 16451992 SGTC_831 k061-1017 217 µM -0.819916838782109 0.201326576972124 no 2704 0.206131758364732 3920 1240153 SGTC_872 0588-0139 234 µM -0.821038945001991 0.201008693974968 no 2705 0.205812042647968 3840 2047100 SGTC_59 0330-0160 1.33 µM -0.821516166541105 0.200873592541032 no 2706 0.205676159694684 3825 4293482 SGTC_2840 9008771 71.43 µM -0.822078625258721 0.200714430433367 no 2707 0.205516074886966 3828 2992978 SGTC_1064 honokiol 6.76 µM -0.822933029816678 0.200472799658622 no 2708 0.205273039188051 3870 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_465 cgp-37157 41 µM -0.824257714294368 0.200098516479754 no 2709 0.204896569943977 3813 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2370 9071495 200 µM -0.82439025231161 0.200061091635114 no 2710 0.204858925853642 3885 21791103 SGTC_943 3253-1379 105 µM -0.826552258736423 0.199451198848056 no 2711 0.204245443207079 3829 668464 SGTC_1917 st066507 28.5 µM -0.826892167100736 0.199355414067815 no 2712 0.204149091730379 3850 3156428 SGTC_1975 st070967 30.8 µM -0.827014534046654 0.199320938346667 no 2713 0.204114411845634 3828 261391 SGTC_1473 k844-0725 134 µM -0.82792089373735 0.19906569193373 no 2714 0.203857650693384 3924 54682906 SGTC_286 k060-0067 22.9 µM -0.829374237748057 0.198656816676791 no 2715 0.203446337299452 3864 5985051 SGTC_2121 5257820 149.641 µM -0.829909314420692 0.198506408999058 no 2716 0.20329502910574 3947 791256 SGTC_1012 4112-3522 18 µM -0.830440207525544 0.198357245217778 no 2717 0.203144970325123 3857 3112398 SGTC_1996 st072960 66.8 µM -0.831566025140974 0.198041150789649 no 2718 0.202826972933369 3847 1719405 SGTC_660 4031-1742 102 µM -0.831760687859629 0.19798652643902 no 2719 0.20277201885432 3804 6738706 SGTC_2581 avocatin a 64 µM -0.832221699452036 0.197857198167754 no 2720 0.202641908889021 3886 6710728 A skin care supplement. SGTC_2368 9071271 200 µM -0.832698755183404 0.197723422756343 no 2721 0.202507323377533 3885 27209959 SGTC_358 0075-0058 9.45 µM -0.834723965644369 0.197156124422864 no 2722 0.20193657239669 3771 1069125 SGTC_1294 1000-1494 117 µM -0.835389487912456 0.196969914728085 no 2723 0.201749223302439 3869 712797 YDL207W GLE1 SGTC_2669 eugenol 100 µM -0.837413036693856 0.196404390519329 no 2724 0.20118022016321 3844 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3210 9128157 49.47 µM -0.837642597327189 0.196340297076988 no 2725 0.201115730675057 3961 17590849 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.840639451069322 0.195504737671949 no 2726 0.200274975259835 3969 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2363 9053361 176 µM -0.84359339612401 0.194683258586698 no 2727 0.199448327905755 3952 6469797 YMR079W SEC14 SGTC_3214 9129694 49.47 µM -0.845362260462255 0.194192352040066 no 2728 0.198954304433378 3884 17158655 SGTC_3249 9135183 49.47 µM -0.846092521138804 0.1939899054962 no 2729 0.198750566279032 3910 4902779 SGTC_2909 7941780 10.49 µM -0.846371585368151 0.193912575878981 no 2730 0.198672742339498 3845 1243215 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.848346176310991 0.193365947143683 no 2731 0.198122604192608 3998 688801 SGTC_3127 9126946 49.47 µM -0.848929242239991 0.193204716178497 no 2732 0.1979603330351 3894 27243249 SGTC_1841 st054148 70 µM -0.849254096582045 0.193114922184657 no 2733 0.197869958725822 3946 675442 SGTC_2330 7979373 200 µM -0.849831451618946 0.192955396585172 no 2734 0.197709400381434 3858 1863007 SGTC_567 1080-0542 68.4 µM -0.851481519354388 0.192499919878039 no 2735 0.19725096248865 3804 5950415 SGTC_1444 4112-3581 28 µM -0.852596581236751 0.192192496081471 no 2736 0.196941529558979 3934 2877249 SGTC_51 1013-0126 23.419 µM -0.854226487648271 0.191743669801488 no 2737 0.196489754820654 3910 1627850 SGTC_1447 4239-0816 81.9 µM -0.855980767167765 0.191261312790807 no 2738 0.196004208909992 3911 1341554 SGTC_2136 5328288 199.296 µM -0.856227943022394 0.191193409108578 no 2739 0.19593585463013 3924 262395 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.856573459002464 0.191098514387369 no 2740 0.19584032950729 3957 1273210 SGTC_1376 2910-0861 41.3 µM -0.857588554888255 0.190819889062962 no 2741 0.195559848535771 3863 1112859 SGTC_1228 0124-0032 52.5 µM -0.858307592690595 0.190622677183386 no 2742 0.195361318987852 3991 X1228 SGTC_3073 9114972 49.47 µM -0.861372514741456 0.189783459211382 no 2743 0.194516454435186 3885 41905075 SGTC_297 0986-0032 24 µM -0.863508063792959 0.189200061659949 no 2744 0.193929093887961 3883 2847425 SGTC_31 0508-1974 57.237 µM -0.863828486836193 0.189112622623074 no 2745 0.193841058210886 3871 6810525 SGTC_14 0354-0009 295 µM -0.86386424478118 0.189102866316036 no 2746 0.193831235288467 3991 1713507 SGTC_3052 9092717 49.47 µM -0.86576010951428 0.188586036771085 no 2747 0.193310864446443 3930 25237534 SGTC_2223 6903751 107.57 µM -0.866499203682184 0.188384789306462 no 2748 0.193108231436724 3879 5598863 SGTC_1720 st037298 9.481 µM -0.869148265539054 0.18766456688562 no 2749 0.192383020023018 3955 597396 SGTC_89 0302-0250 142.109 µM -0.87067074253377 0.187251409251051 no 2750 0.191966978920313 4010 4203518 YLR208W SEC13 SGTC_996 3970-0799 1.8 µM -0.870959834711822 0.187173021311573 no 2751 0.191888042128785 3966 6615648 YGL040C HEM2 SGTC_1453 4237-0541 195 µM -0.871135170216064 0.187125488616682 no 2752 0.191840176346286 3872 739892 SGTC_2998 9066762 71.4286 µM -0.872844147972861 0.186662583262707 no 2753 0.191374016253188 3955 4945196 SGTC_2741 miltefosine 3.04 µM -0.875585387490476 0.18592155460065 no 2754 0.190627736048856 3898 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3242 9133940 49.47 µM -0.875744558134639 0.185878582726768 no 2755 0.190584458077768 3950 17248444 SGTC_506 n9-isopropylolomoucine 153 µM -0.876666244535402 0.185629872833449 no 2756 0.190333973202061 3928 6610355 SGTC_1514 1189-1591 158 µM -0.877484379587928 0.185409278540255 no 2757 0.19011179976326 3988 767698 YMR146C TIF34 SGTC_75 0159-0059 199.013 µM -0.877772468141372 0.185331639790032 no 2758 0.190033604149894 3975 5377270 SGTC_1489 4065-0444 182 µM -0.878772507578299 0.185062289713278 no 2759 0.189762317803735 3890 2877968 SGTC_3191 9110352 49.47 µM -0.879238947458495 0.184936742258983 no 2760 0.189635865515612 3890 17122424 SGTC_2102 5377816 72.7585 µM -0.87942284018165 0.184887260047592 no 2761 0.189586026276023 3991 1379702 SGTC_3042 9091578 49.47 µM -0.87981090141363 0.18478286678202 no 2762 0.189480879032485 3888 25236497 SGTC_578 3460-0051 92 µM -0.879994213564614 0.184733566293115 no 2763 0.189431222117574 4003 2876744 SGTC_607 4491-0986 66.8 µM -0.882214976696082 0.18413695771785 no 2764 0.188830282213829 3959 698981 YDR232W HEM1 SGTC_2558 carylophyllene oxide 100 µM -0.882339159587477 0.184103631398912 no 2765 0.188796712964018 4041 6708694 An oxygenated terpenoid and antifungal agent. SGTC_318 1488-0629 67.2 µM -0.883036074565633 0.183916673607881 no 2766 0.188608390416991 3989 3662576 SGTC_2235 salicylic acid 500 µM -0.883392830141899 0.183821014397232 no 2767 0.188512031641677 3964 338 A COX inhibitor and kinase inhibitor. SGTC_2729 fluphenazine 10.66 µM -0.884990651637823 0.183392960383829 no 2768 0.188080836677172 3891 3372 An atypical antipsychotic. SGTC_403 arphamenine a 50 µM -0.886250011646609 0.18305601800094 no 2769 0.187741409742946 3920 5487158 An arginine aminopeptidase inhibitor. SGTC_1135 dihydrocapsaicin 536.708 nM -0.886429287682933 0.183008084033171 no 2770 0.187693121447567 3874 107982 A Capsaicinoid. SGTC_2793 7325131 81.82 µM -0.890329367913219 0.181967238343762 no 2771 0.186644528156684 3935 4176441 SGTC_1861 st057647 17.4 µM -0.890403691958891 0.181947438901998 no 2772 0.186624580339624 4056 688668 SGTC_353 1988-1175 58.3 µM -0.891171187472929 0.181743061886725 no 2773 0.1864186695603 3798 2788357 SGTC_2582 agaric acid 100 µM -0.891805166227354 0.181574347524248 no 2774 0.186248686069035 3754 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2910 7948405 25.97 µM -0.892838096681829 0.181299674203695 no 2775 0.185971940751001 3858 2971328 SGTC_534 k292-0788 63.4 µM -0.894392524362561 0.180886816824706 no 2776 0.185555955422837 3955 4146317 SGTC_225 nsc-122657 1.016 µM -0.897291997033278 0.18011829042359 no 2777 0.184781562899329 3966 275685 SGTC_2059 5238311 157 µM -0.8978942426458 0.179958918293418 no 2778 0.184620967184998 3962 703021 SGTC_1529 apigenin 74 µM -0.898459233923376 0.179809485302897 no 2779 0.184470384696446 3973 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_968 1309-0633 340 µM -0.899947152088654 0.179416322984722 no 2780 0.184074187730873 4020 3761976 SGTC_832 4083-0019 164 µM -0.900114914681239 0.179372027909841 no 2781 0.184029549826289 4030 1990758 SGTC_69 0096-0274 206.684 µM -0.900133643194963 0.179367083366934 no 2782 0.184024567002438 4125 6741392 SGTC_3279 9140807 49.47 µM -0.901152652973001 0.179098182263913 no 2783 0.183753580490708 4004 45595718 SGTC_477 mead ethanolamide 10 µM -0.901408668455064 0.179030663574707 no 2784 0.183685537074775 3841 16061185 SGTC_1941 st076221 61.8 µM -0.904718413384247 0.178159230400915 no 2785 0.182807291802636 3903 2828568 SGTC_3205 9113483 49.47 µM -0.908539635586301 0.177156460269748 no 2786 0.181796591374105 4052 17018033 SGTC_710 3448-4187 58 µM -0.90991030454443 0.17679763797994 no 2787 0.181434907476114 3955 3946412 SGTC_2207 7258803 200 µM -0.911487434823263 0.176385335812118 no 2788 0.181019301587174 3946 3666799 SGTC_989 1501-0895 10.3 µM -0.915284728730699 0.175395124103465 no 2789 0.180021087007951 3940 2830112 SGTC_987 1497-1013 404 µM -0.915496425550504 0.175340024312634 no 2790 0.179965539054826 3934 1676435 SGTC_2900 5328528 85.29 µM -0.917556632666999 0.174804373226408 no 2791 0.179425515478785 4003 795359 SGTC_376 3970-0862 59.1 µM -0.9176709811916 0.174774673219369 no 2792 0.17939557219849 4031 3135186 SGTC_2366 9070441 60.58 µM -0.918037202470269 0.174679575277387 no 2793 0.179299694717546 4005 6837235 SGTC_1414 3917-0015 5.4 µM -0.919677546959268 0.174254024596459 no 2794 0.178870644673534 3943 6618702 SGTC_1919 st067113 52.3 µM -0.922063944261511 0.17363610465108 no 2795 0.178247611311235 4046 1268243 SGTC_840 0245-0196 390 µM -0.92306080358019 0.173378396991658 no 2796 0.177987759776125 4096 3827528 SGTC_3176 9106582 49.47 µM -0.923201566943454 0.173342026533743 no 2797 0.177951086215377 3936 17018027 SGTC_467 ro 31-8220 72.8 µM -0.925993445606536 0.172621664279131 no 2798 0.177224693245276 3938 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1658 st012944 20 µM -0.927235036302889 0.172301922327335 no 2799 0.176902257738234 3892 24207260 SGTC_2999 9069765 71.4286 µM -0.927253863318286 0.172297076790465 no 2800 0.176897371302449 3998 2097066 SGTC_939 1165-0479 45.3 µM -0.931861962602338 0.171113698744053 no 2801 0.175703933730242 3996 1377347 SGTC_1939 st074455 53.6 µM -0.934422909560891 0.170458290061667 no 2802 0.175042892374557 4043 1644229 SGTC_613 3914-0030 117 µM -0.934574870902716 0.170419450047999 no 2803 0.175003717188518 3737 1145395 SGTC_759 3486-0358 89.3 µM -0.935557410572383 0.170168458164124 no 2804 0.17475055563481 3989 875103 SGTC_1849 st056239 19.2 µM -0.935853841047111 0.170092780893751 no 2805 0.174674222916207 4029 5393181 SGTC_913 3487-1245 167 µM -0.937677713109867 0.169627629872872 no 2806 0.174205030282763 3953 4016153 SGTC_930 2810-3379 265 µM -0.938775779563082 0.16934797851138 no 2807 0.173922938387015 4057 1015764 SGTC_2854 9024559 71.43 µM -0.93944228652006 0.169178379474788 no 2808 0.17375185532963 4070 3163529 SGTC_2414 st077232 92.9 µM -0.940047123330708 0.169024567414335 no 2809 0.173596694824676 3971 729801 SGTC_646 4092-0839 27.3 µM -0.944018766132801 0.168016797322025 no 2810 0.172580029307316 4068 877796 SGTC_746 1095-0025 46.6 µM -0.945596338148377 0.167617577321389 no 2811 0.172177256340486 4047 6749286 SGTC_163 TUB2.036 7.546 µM -0.947368627342917 0.167169811606187 no 2812 0.171725485876288 4010 15992207 YJR013W GPI14 SGTC_2764 methyldopa 94.69 µM -0.947571965356517 0.167118487975247 no 2813 0.171673701878873 4022 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_577 r071-0003 38.6 µM -0.948352789241863 0.16692149816159 no 2814 0.171474942537047 4056 4568517 YMR134W ERG29 SGTC_3045 9092950 49.47 µM -0.950778185591023 0.166310563669254 no 2815 0.170858494292754 3984 44120432 SGTC_3297 9117502 71.43 µM -0.950797795502686 0.166305630009372 no 2816 0.170853515946786 4046 7453720 SGTC_3209 9113616 49.47 µM -0.951207960657539 0.16620245817617 no 2817 0.170749409060474 4088 16649353 SGTC_374 0880-0231 82.3 µM -0.951548429429425 0.166116848991715 no 2818 0.170663023145603 3951 6833587 SGTC_2176 5809774 33.9695 µM -0.951857185615717 0.166039238415724 no 2819 0.170584707744763 4002 2870539 SGTC_1049 3226-0134 66 µM -0.952669359956561 0.165835197902041 no 2820 0.170378811203352 4076 5702385 SGTC_3054 9094397 49.47 µM -0.953795156217106 0.165552635107316 no 2821 0.170093670873518 4045 2598354 SGTC_2473 5854593 8.94 µM -0.955330225847272 0.165167851164256 no 2822 0.169705363388402 3937 2872951 SGTC_2171 5739187 198.077 µM -0.956104431040117 0.164974006958017 no 2823 0.169509738184387 3976 2262761 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.958236892493007 0.164440846822977 no 2824 0.168971658954793 4035 676296 Flavone; oxidizing agent. SGTC_1875 nocodazole 6 µM -0.958445304390073 0.16438879945322 no 2825 0.168919129763901 4052 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1325 1431-0015 227 µM -0.960475588044351 0.163882329064164 no 2826 0.168407955747737 4034 1103340 SGTC_2918 7977171 22.06 µM -0.962759973613126 0.163313682881578 no 2827 0.167833995900285 4000 2236483 SGTC_798 1287-0182 476 µM -0.96277454903195 0.163310058780788 no 2828 0.167830337823523 4089 1649755 SGTC_1603 st002045 67.8 µM -0.965133349535952 0.162724243970999 no 2829 0.167239012487441 4044 5887985 SGTC_3164 9100705 49.47 µM -0.965395457533376 0.162659233187112 no 2830 0.167173387901923 4081 17174235 SGTC_410 α-linolenic acid 100 µM -0.965933966717157 0.162525719495574 no 2831 0.167038612210884 4122 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_664 1222-0054 14.9 µM -0.96759733469844 0.162113767690047 no 2832 0.166622754451241 4020 6813991 SGTC_1259 0671-0132 43 µM -0.967996745048606 0.162014950551997 no 2833 0.166522997649022 3968 X1259 SGTC_189 3970-0742 2.116 µM -0.971149080155822 0.16123641613769 no 2834 0.165737023119573 3983 2891807 SGTC_132 0417-1715 25.805 µM -0.971242073207197 0.161213486699152 no 2835 0.165713873558582 4003 6769098 SGTC_1711 st032263 62.8 µM -0.975967743314203 0.160051072056936 no 2836 0.164540224754281 4057 3958979 SGTC_2073 5212005 126 µM -0.977649799698685 0.159638647687711 no 2837 0.164123779031526 3845 691789 SGTC_1119 parthenolide 318.541 nM -0.978662220511578 0.159390747225909 no 2838 0.16387345243251 4182 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_280 3448-3607 3.04 µM -0.979669006563489 0.159144476567034 no 2839 0.163624764898494 4041 626179 SGTC_156 3474-0145 5.642 µM -0.981334029522363 0.158737741360854 no 2840 0.163214023407746 3895 2265471 SGTC_2870 9038528 12.99 µM -0.981427804240239 0.158714854170699 no 2841 0.163190910239658 4131 6463316 SGTC_663 1486-0733 13.9 µM -0.9816469893241 0.158661367052964 no 2842 0.163136894788361 4089 722445 YPR165W RHO1 SGTC_2107 5363541 170.161 µM -0.982502461559642 0.158452721670965 no 2843 0.162926185432977 4046 244052 SGTC_2748 diazoxide 86.69 µM -0.984922525423251 0.157863455403839 no 2844 0.162331063964918 4103 3019 A potassium channel activatior. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.985706385267028 0.157672900724029 no 2845 0.162138607607797 4017 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2318 6029776 164 µM -0.988606155539814 0.15696928666718 no 2846 0.161427936672361 4112 818325 SGTC_3329 9141233 27.5565 µM -0.989310581660749 0.15679867367599 no 2847 0.1612556041987 4053 4909101 YNL103W MET4 SGTC_1249 0481-0015 10.2 µM -0.992031214371882 0.156140878863373 no 2848 0.160591149439342 4033 4227577 SGTC_485 niflumic acid 177 µM -0.993019636034488 0.1559023491385 no 2849 0.160350192679641 4138 4488 A COX2 inhibitor. SGTC_1149 3909-7961 23.3 µM -0.993702013991308 0.1557378152961 no 2850 0.160183980976587 4108 735261 SGTC_112 phenothiazine 287.218 µM -0.993779888979085 0.155719045490229 no 2851 0.16016501956874 4006 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1399 3562-5772 25 µM -0.995010535355037 0.155422627220338 no 2852 0.1598655701953 4034 23847490 SGTC_370 0180-0345 38.7 µM -0.995084497185192 0.155404824354479 no 2853 0.159847584965787 3946 3989527 SGTC_2247 cerulenin 830 nM -0.996127348193384 0.155153949791672 no 2854 0.159594136760121 4137 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2746 daunorubicin 9.88 µM -0.996884053081359 0.154972079756358 no 2855 0.159410396525051 4009 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_651 3253-0966 34.4 µM -0.999469747684632 0.154351684570412 no 2856 0.158783593485537 4101 781462 SGTC_1191 1487-1166 10.6 µM -1.00003805718504 0.154215548425096 no 2857 0.15864604538205 4127 3955771 SGTC_1093 fluphenazine 7.97 µM -1.00056800272152 0.154088673779125 no 2858 0.158517852934557 4086 6602611 An atypical antipsychotic. SGTC_1244 0416-0015 52.5 µM -1.00115594835858 0.153947994111855 no 2859 0.158375709932239 4060 96201 SGTC_474 dl-dihydrosphingosine 5 µM -1.00321634209948 0.153455667979025 no 2860 0.157878244877398 4114 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1265 0819-1001 68.8 µM -1.00756863929816 0.152419128693529 no 2861 0.156830795292677 4060 3106768 SGTC_766 1391-0721 126 µM -1.01417056999609 0.150855708740883 no 2862 0.155250684504103 4139 1020919 YIL115C NUP159 SGTC_1252 0493-0875 34.8 µM -1.01636403005777 0.15033864088225 no 2863 0.154728033920512 4100 3960963 SGTC_906 1165-0455 526 µM -1.0164940435196 0.150308029718533 no 2864 0.154697091271134 4079 3252859 SGTC_2576 guaiol 23.12 µM -1.01704711681787 0.150177857180857 no 2865 0.154565507880464 4035 227829 SGTC_827 3253-0474 693 µM -1.01740998493044 0.150092492586006 no 2866 0.154479216997704 4157 5402065 SGTC_1033 k072-0102 21.3 µM -1.01835474609187 0.149870389635692 no 2867 0.154254700010882 4090 5965931 SGTC_2514 salinomycin 42.74 µM -1.0208948157902 0.149274334605779 no 2868 0.153652137790474 4164 23682228 A polyether potassium ionophore. SGTC_2364 9055074 200 µM -1.02599990241721 0.148081163921161 no 2869 0.152445815031211 4138 6470630 SGTC_2786 7743617 45.45 µM -1.02632628800949 0.148005098131436 no 2870 0.152368905054916 4076 583674 SGTC_1231 0242-0792 125 µM -1.02662939336717 0.147934481341557 no 2871 0.152297503935418 4108 3707635 SGTC_1287 0971-0001 34.6 µM -1.02702792774942 0.147841666046068 no 2872 0.15220365685141 4108 4665869 SGTC_1458 k015-0034 6.33 µM -1.02758645086674 0.147711656345625 no 2873 0.152072200161068 4151 3598957 SGTC_922 1866-0035 480 µM -1.02932548696987 0.147307344295326 no 2874 0.151663375276583 4058 3156169 SGTC_3354 9151612 71.43 µM -1.03031053120906 0.147078658706163 no 2875 0.151432128495567 4144 27261949 SGTC_1942 st076330 65.2 µM -1.03202118432912 0.146682083366545 no 2876 0.151031096794372 4196 24208414 SGTC_806 3966-4455 5.86 µM -1.03294117695299 0.146469101343034 no 2877 0.150815713667568 4117 714982 SGTC_2879 9041815 71.43 µM -1.03525347015598 0.145934713060882 no 2878 0.150275276768594 4133 4942971 SGTC_869 0564-0080 44.1 µM -1.03641916965713 0.14566580851204 no 2879 0.150003315504132 4134 6843321 SGTC_500 h-89 112 µM -1.03646971230064 0.145654156832019 no 2880 0.149991531178254 4153 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2768 sulfasalazine 50.2 µM -1.03691084542469 0.145552488277648 no 2881 0.149888704503774 4066 5384001 An antioxidant and salicylic acid derivative. SGTC_1400 3771-8998 51.5 µM -1.03883670929486 0.145109190836396 no 2882 0.149440342746876 4030 670767 SGTC_697 0508-1955 564 µM -1.03987312973271 0.144871002918699 no 2883 0.149199423858385 4131 6243113 SGTC_2367 9070478 135.38 µM -1.03990723836479 0.144863168623075 no 2884 0.1491914996204 4088 572802 SGTC_193 1273-0060 1.558 µM -1.04410153103539 0.143901969818509 no 2885 0.148219208804531 3938 2847393 YHR072W ERG7 SGTC_904 1141-0088 396 µM -1.04416413025782 0.143887656722632 no 2886 0.148204729684126 4136 1378119 SGTC_2810 7959871 45.46 µM -1.04504332039921 0.143686734395791 no 2887 0.148001474106933 4105 2974535 SGTC_3309 9129340 25.759 µM -1.04532773607744 0.14362177710682 no 2888 0.147935761427502 4158 17158987 SGTC_765 1319-0117 244 µM -1.04619580718616 0.143423642163509 no 2889 0.147735319160124 4098 3487746 YGL099W LSG1 SGTC_2382 9035899 200 µM -1.04701167968484 0.143237589727744 no 2890 0.147547095702253 4120 6462679 SGTC_2103 5378138 10 µM -1.04852982572605 0.142891824118225 no 2891 0.147197284054367 4207 244142 SGTC_1656 st012921 11 µM -1.05002325509191 0.142552238683163 no 2892 0.146853710510853 4057 6732821 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.05547732701934 0.141316696174988 no 2893 0.145603536830809 4093 97141 SGTC_2532 xanthone 78.9 µM -1.05704862400353 0.140962092069393 no 2894 0.145244698338949 4147 7020 An insecticide. SGTC_1014 4130-3005 69.3 µM -1.05795313406592 0.140758239749879 no 2895 0.145038404646318 4156 743608 SGTC_383 2324-0395 7.37 µM -1.05999678862882 0.140298391671932 no 2896 0.144573030154576 4156 3146421 SGTC_1832 st054113 55 µM -1.0619120765742 0.139868354831825 no 2897 0.144137801043135 4158 1251267 SGTC_991 3996-0057 64.7 µM -1.06397469916261 0.139406240076091 no 2898 0.143670080625047 4227 715343 SGTC_2636 apigenin dimethyl ether 100 µM -1.064622299469 0.139261364684339 no 2899 0.143523442250884 4150 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1948 st076329 66.6 µM -1.06478232832116 0.13922558024181 no 2900 0.143487221938271 4026 24208413 SGTC_592 k241-0073 46.5 µM -1.06804965925025 0.138496332355883 no 2901 0.142749055966807 4193 4230158 SGTC_835 0312-0010 67.2 µM -1.06851620758035 0.138392414436088 no 2902 0.142643861692553 4144 1626196 SGTC_2391 6285546 200 µM -1.06970166432754 0.138128607595991 no 2903 0.142376808479952 4151 846083 SGTC_1441 4106-0040 13 µM -1.0727438177551 0.137453188730688 no 2904 0.141693037285125 4161 2904180 SGTC_3341 9147222 25.867 µM -1.07295738169571 0.137405858117866 no 2905 0.141645119173897 4167 1939759 SGTC_1882 5615643 20 µM -1.07332278764724 0.137324901683541 no 2906 0.141563157185924 4119 2253075 SGTC_3302 9125395 16.351 µM -1.07379719033773 0.137219845405025 no 2907 0.141456794750689 4119 17599668 SGTC_1856 st057054 55.7 µM -1.07577075783469 0.136783389015699 no 2908 0.141014896659458 4180 1266018 SGTC_2607 solasodine 47.35 µM -1.07613716830241 0.136702461547693 no 2909 0.140932957484446 4148 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2692 st077426 47.7 µM -1.07626113913024 0.136675088069485 no 2910 0.140905241607161 4192 25238571 SGTC_2248 tofa 1.1 µM -1.07629762158869 0.136667033244731 no 2911 0.14089708601074 4132 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_855 0428-0020 25 µM -1.07658021749514 0.136604650952423 no 2912 0.140833922985998 4196 6812414 SGTC_1623 st003709 20.3 µM -1.0783251991958 0.136219882253801 no 2913 0.140444327624573 4129 16192618 SGTC_2162 5663267 200 µM -1.07926956835953 0.136011958309135 no 2914 0.140233787399418 4171 6456493 SGTC_1596 piperlongumine 63 µM -1.08529980342754 0.134689391389618 no 2915 0.138894446470596 4226 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_326 k292-0812 17.5 µM -1.0853410930539 0.134680366168039 no 2916 0.138885305994076 4160 3579357 SGTC_519 k048-0011 62.8 µM -1.08545694975477 0.134655044047554 no 2917 0.138859660444795 4222 6836379 SGTC_1225 1216-0074 20.6 µM -1.08663103018431 0.134398616496289 no 2918 0.138599952889655 4197 4241466 SGTC_986 1493-0483 84 µM -1.08726581999464 0.134260113605515 no 2919 0.138459674777543 4137 40079 SGTC_2708 st078559 56 µM -1.08730774836704 0.13425096883183 no 2920 0.138450412704127 4120 17250902 SGTC_2536 dehydroabietamide 32.04 µM -1.08872658502337 0.133941766093418 no 2921 0.1381372373209 4275 3983547 SGTC_292 k038-0015 474 µM -1.09110794959108 0.133423903306937 no 2922 0.137612692627022 4182 46368540 SGTC_1353 1498-1206 8.11 µM -1.09551071380548 0.132470088299383 no 2923 0.136646477188722 4222 6756808 SGTC_818 4072-2707 53.5 µM -1.09608118843467 0.132346845353741 no 2924 0.136521623097733 4089 882871 SGTC_774 k060-0086 136 µM -1.09757196158088 0.132025158143628 no 2925 0.136195720886049 4205 5911235 SGTC_529 4076-0302 30.3 µM -1.09846813472121 0.13183203670251 no 2926 0.136000062327498 4149 5816522 SGTC_492 tmb-8 126 µM -1.10009968544149 0.131480945139631 no 2927 0.135644345446589 4149 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_321 4534-3890 65.3 µM -1.10117484845857 0.131249935149446 no 2928 0.135410283021622 4193 699746 SGTC_1079 idarubicin 2.36 µM -1.10142099153972 0.131197088196487 no 2929 0.135356736763905 4204 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2325 6158266 200 µM -1.10240968849022 0.130984962913679 no 2930 0.135141800694611 4211 3623240 SGTC_50 0929-0078 56.389 µM -1.10275532020668 0.13091086343854 no 2931 0.135066717918733 4049 1377751 SGTC_2682 pyrogallin 40.03 µM -1.1036922295341 0.130710146533848 no 2932 0.134863333752617 4192 822798 An ATP competetive kinase inhibitor. SGTC_1143 3454-2408 5.08 µM -1.10848435289022 0.129686843002763 no 2933 0.133826346507704 4207 X1143 SGTC_1800 st050079 29.0735 µM -1.10888291428304 0.129601985361689 no 2934 0.133740347710105 4064 3645560 SGTC_1011 4112-3381 17.4 µM -1.11119343744981 0.129110810067107 no 2935 0.133242547705345 4279 2877139 SGTC_1801 st050089 28.441 µM -1.11339682105223 0.128643614342824 no 2936 0.132769019846718 4249 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3111 9122088 49.47 µM -1.12054536403989 0.127135951407514 no 2937 0.131240716278607 4058 16876704 SGTC_1954 st077032 68.9 µM -1.12141485910656 0.126953412750668 no 2938 0.131055657049786 4175 698907 SGTC_3343 9148379 18.9835 µM -1.12219670977473 0.126789429680826 no 2939 0.130889405645679 4242 1955036 SGTC_2814 7977482 42.97 µM -1.12299399310649 0.12662236174126 no 2940 0.130720022814621 4245 6456762 SGTC_1972 st070201 17.4 µM -1.12427262080814 0.126354749996723 no 2941 0.13044869485993 4226 2829099 SGTC_2740 felodipine 17.08 µM -1.12449251487976 0.126308766779113 no 2942 0.130402072077002 4242 3333 L-type calcium channel blocker SGTC_7 0192-1582 4.227 µM -1.12497956523425 0.126206958615628 no 2943 0.130298846836201 4259 252616 SGTC_848 0368-0089 85.6 µM -1.12525196971714 0.126150042837827 no 2944 0.130241138204781 4226 762535 SGTC_658 3253-0951 102 µM -1.12616548909201 0.125959304110349 no 2945 0.130047739093177 4217 1184878 SGTC_3061 glucosamine 200 µM -1.12931068352794 0.125304140186577 no 2946 0.129383397825883 4153 91431 and experimental redox chemotherapeutic SGTC_2616 abietic acid 100 µM -1.13262139250873 0.124617072726605 no 2947 0.128686640525757 4271 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1305 1181-0477 144 µM -1.1330906279595 0.124519906336205 no 2948 0.128588098336959 4283 6252086 SGTC_3207 9114163 49.47 µM -1.13339279888175 0.124457362685018 no 2949 0.128524668402501 4255 849233 SGTC_1574 spiramycin 23.7 µM -1.13374970680973 0.124383517809662 no 2950 0.128449776376767 4187 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1115 galangin 695.678 nM -1.13407973042867 0.124315262614663 no 2951 0.128380552600035 4290 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1051 3253-3903 78 µM -1.13510141484354 0.124104124834059 no 2952 0.128166414415899 4202 5509239 SGTC_501 nsc-95397 161 µM -1.13693622088463 0.12372558028385 no 2953 0.127782474456166 4264 262093 SGTC_2482 5981709 142.65 µM -1.13764253511747 0.123580074113414 no 2954 0.127634888887264 4166 877755 SGTC_368 fentichlor 4.58 µM -1.14013801231407 0.123066946432493 no 2955 0.127114403784229 4254 7329 A pesticide. SGTC_511 blebbistatin 171 µM -1.14297426153483 0.122485563684271 no 2956 0.126524638801679 4293 3476986 A myosin inhibitor. SGTC_2361 9034121 116 µM -1.14510519159215 0.122050029161405 no 2957 0.126082792588621 4244 6496917 SGTC_575 k072-0246 11.9 µM -1.14750460951844 0.121560922278812 no 2958 0.125586564570118 4318 6796779 SGTC_1851 st056236 18.9 µM -1.15190121290295 0.120668279705677 no 2959 0.124680834887744 4241 5393171 SGTC_3310 9130229 44.1445 µM -1.15212769049619 0.12062242325508 no 2960 0.124634302953587 4274 7761258 SGTC_490 phenamil 164 µM -1.15427621312623 0.120188007582176 no 2961 0.124193472697058 4217 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_792 4534-1957 155 µM -1.15446700424921 0.120149484363668 no 2962 0.124154379291597 4208 1717904 SGTC_1587 estradiol valerate 56.1 µM -1.16033771118331 0.118968362681085 no 2963 0.122955668182371 4304 13791 A steroid. SGTC_2866 9034245 58.44 µM -1.16311182050436 0.118413104221679 no 2964 0.122392068412117 4234 6462273 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.16704614727678 0.117628764833405 no 2965 0.121595866957822 4288 6728940 SGTC_2855 9016525 58.44 µM -1.16907584460794 0.117225569575374 no 2966 0.121186537542958 4209 43811474 SGTC_1116 jasmonic acid  1.58368 µM -1.17000338021704 0.117041642784179 no 2967 0.120999804276917 4309 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_55 0767-0285 6.563 µM -1.17055735993767 0.116931888294756 no 2968 0.120888372617837 4178 3116166 SGTC_871 0574-0004 149 µM -1.17122999994152 0.116798722902636 no 2969 0.120753169835487 4228 9551173 SGTC_2736 butenafine 14.65 µM -1.17272466937177 0.116503201814029 no 2970 0.120453117650473 4193 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_700 3453-2283 142 µM -1.1748638422934 0.116081174904975 no 2971 0.120024596708579 4324 565664 SGTC_3236 9132701 49.47 µM -1.17802241787846 0.115460020913155 no 2972 0.119393834559916 4261 24282524 SGTC_2110 5483698 200 µM -1.18018083287242 0.115036915602866 no 2973 0.118964150302754 4247 2848765 YHR062C RPP1 SGTC_1185 1319-0113 81.3 µM -1.18041813509567 0.114990465575492 no 2974 0.118916976318287 4335 4672763 SGTC_3041 9091929 49.47 µM -1.1809242619488 0.114891439827594 no 2975 0.118816406060346 4274 25236887 SGTC_3095 9117207 49.47 µM -1.18353346665303 0.114381900864572 no 2976 0.11829889557904 4244 17015229 SGTC_1773 st048542 73.5835 µM -1.18574688416029 0.113950916258793 no 2977 0.117861136653731 4237 3237138 SGTC_2707 st078556 66.6 µM -1.19088674377577 0.112954576992085 no 2978 0.116849024627938 4214 17250899 SGTC_1446 4239-0190 62 µM -1.19117939638968 0.112898035252979 no 2979 0.116791583080248 4292 1340085 SGTC_1198 1612-1005 86.7 µM -1.19268961096525 0.112606576466755 no 2980 0.116495477938759 4343 6998509 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.19460663234634 0.112237381927313 no 2981 0.116120378369379 4265 15053 SGTC_1675 st018485 24.5 µM -1.19727821471317 0.111724312361185 no 2982 0.115599066386962 4308 3323024 SGTC_2925 9010536 32.5 µM -1.19742221799895 0.111696704683626 no 2983 0.115571013997502 4203 2994177 SGTC_497 capsazepine 133 µM -1.20071454855574 0.11106684431864 no 2984 0.114930974339843 4241 2733484 A calcium channel blocker. SGTC_2150 5556613 200 µM -1.20146423896504 0.110923776241649 no 2985 0.114785585189206 4305 743190 SGTC_1643 st009866 20.2 µM -1.20346899842728 0.110541844190959 no 2986 0.114397440600885 4235 3156273 YOR207C RET1 SGTC_1239 0337-0584 35.4 µM -1.20380586026669 0.110477760365696 no 2987 0.114332312063694 4355 914301 YML130C ERO1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.20427992727025 0.110387620065757 no 2988 0.114240701142149 4243 6708514 SGTC_2839 9003951 25.97 µM -1.20526772354911 0.110199967426633 no 2989 0.114049982744747 4340 2990634 SGTC_2628 lathosterol 100 µM -1.20560420095786 0.110136098753045 no 2990 0.113985069313825 4358 6710616 SGTC_2455 5377712 9.75 µM -1.20620926367155 0.110021315203557 no 2991 0.113868406474225 4273 2243908 SGTC_2744 captopril 92.04 µM -1.20740929438129 0.109793917103565 no 2992 0.113637278951851 4356 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2983 9022671 12.99 µM -1.21023932164715 0.109258981513471 no 2993 0.113093536803727 4281 6405161 SGTC_2677 mitomycin C 100 µM -1.21203402867311 0.108920715303657 no 2994 0.112749677498471 4354 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2320 7373003 200 µM -1.21418998352677 0.108515357384028 no 2995 0.112337592275261 4323 5415828 SGTC_1897 st060201 15 µM -1.21791901653697 0.107816796785355 no 2996 0.111627374461369 4305 611878 SGTC_1127 asiatic acid 681.4 nM -1.21961065584151 0.107500971825963 no 2997 0.111306252497036 4232 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2295 7971645 200 µM -1.22091445617852 0.107258010825965 no 2998 0.111059205210047 4350 2978226 YKL099C UTP11 SGTC_1072 oxiconazole 14.9 nM -1.22110210340376 0.107223075697491 no 2999 0.111023681704819 4285 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_841 0251-0215 91.2 µM -1.22956129678921 0.105656701650804 no 3000 0.109430715367954 4341 3888614 SGTC_1706 st031321 9.9705 µM -1.22985874838275 0.105601925767354 no 3001 0.10937500202883 4323 6103185 SGTC_458 nppb 133 µM -1.23108137382937 0.105376994246132 no 3002 0.109146215576919 4363 4549 A chloride channel blocker. SGTC_3277 9138724 49.47 µM -1.23138287752889 0.105321578658942 no 3003 0.109089848937628 4270 15943418 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.23156140152481 0.105288776357043 no 3004 0.109056483429507 4347 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3299 9121982 43.1275 µM -1.23462134019229 0.10472768672429 no 3005 0.108485731505248 4337 17594604 YPL160W CDC60 SGTC_466 geldanamycin 89.2 µM -1.23648272535232 0.104387432448358 no 3006 0.108139591501192 4295 5288382 HSP90 inhibitor. SGTC_3278 9139605 49.47 µM -1.23782338550715 0.104142861514176 no 3007 0.107890777635463 4305 7958859 SGTC_1467 k284-1082 293 µM -1.23789998479852 0.10412890038681 no 3008 0.107876573991955 4288 3334705 SGTC_2976 9009005 19.48 µM -1.23928959686166 0.103875862686243 no 3009 0.107619134971641 4334 2993148 SGTC_505 gw-5074 63.9 µM -1.24063051063312 0.103632115665338 no 3010 0.107371137731123 4346 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1475 4092-1048 11.7 µM -1.24168073635533 0.103441499003761 no 3011 0.10717719008751 4310 2881759 SGTC_2160 5660466 132.927 µM -1.24209494087015 0.103366390631281 no 3012 0.107100767475751 4239 2859134 SGTC_2916 7875993 68.79 µM -1.2436099451322 0.103092009697838 no 3013 0.106821577085194 4157 1299250 SGTC_127 0180-0333 59.125 µM -1.2441487514536 0.102994554646089 no 3014 0.106722410636952 4240 771601 SGTC_2282 7944268 200 µM -1.2446555592252 0.102902948335182 no 3015 0.106629194123073 4329 2970414 SGTC_1317 1273-0028 910 nM -1.24611606066 0.102639291500915 no 3016 0.106360894671812 4338 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1854 st056233 32.9 µM -1.24639287915774 0.102589374280215 no 3017 0.10631009710707 4251 5393174 SGTC_435 c-PAF 6.7 µM -1.24681610384182 0.102513090523235 no 3018 0.106232467157725 4284 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2737 bleomycin 30.5 nM -1.24690885138088 0.10249637883589 no 3019 0.106215460419767 4423 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2194 5927483 104.545 µM -1.2547935413713 0.101082911230019 no 3020 0.104776858899952 4366 760979 SGTC_612 0302-0167 22.4 µM -1.2549788230608 0.101049867977368 no 3021 0.104743223835239 4336 235821 SGTC_2433 5607874 27.82 µM -1.25525731459101 0.101000216435093 no 3022 0.104692682656123 4290 2252428 SGTC_2796 7949634 45.45 µM -1.25596547489714 0.100874040458974 no 3023 0.1045642439262 4306 2971588 SGTC_2700 st077718 96.8 µM -1.26773925748698 0.0987930691091067 no 3024 0.102445540233858 4327 904970 SGTC_3238 9133470 49.47 µM -1.27027947876449 0.0983482442692792 no 3025 0.101992547667268 4347 3534688 SGTC_502 l-744,832 89.3 µM -1.2727011156279 0.0979255524136815 no 3026 0.101562060803334 4352 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_266 formosanin C 406 nM -1.27893175281619 0.0968441298720437 no 3027 0.100460544927369 4193 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3183 9108214 49.47 µM -1.27968961951039 0.0967131910265513 no 3028 0.100327158408399 4320 4974831 SGTC_2663 amphotericin b 100 µM -1.28058931889497 0.0965579161885217 no 3029 0.100168976822901 4368 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_879 0831-1030 162 µM -1.28141193715696 0.0964161047643906 no 3030 0.100024506741606 4353 1549252 SGTC_317 4495-0002 170 µM -1.28156256803996 0.0963901540447587 no 3031 0.09999806909403 4375 15991618 SGTC_1315 1237-0019 3.69 µM -1.28425743869426 0.0959267481746032 no 3032 0.0995259467708185 4356 825140 SGTC_2199 6590217 200 µM -1.28886981321161 0.0951374167842318 no 3033 0.098721675069648 4261 703109 SGTC_3334 9142812 21.919 µM -1.2893910771409 0.095048512827369 no 3034 0.0986310809489884 4363 45283678 SGTC_1346 1488-2224 62.4 µM -1.29183021081556 0.0946333203971952 no 3035 0.0982079752960036 4375 3722427 SGTC_998 3996-0085 177 µM -1.29363617637407 0.094326769089586 no 3036 0.0978955602228613 4374 715391 SGTC_39 0986-0283 58.349 µM -1.29458921777038 0.0941652918142948 no 3037 0.0977309869339033 4430 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2865 9030313 51.95 µM -1.2953226008055 0.0940411709638443 no 3038 0.0976044828992676 4339 42562754 SGTC_2560 caryophyllene 100 µM -1.29572434722159 0.0939732288978958 no 3039 0.0975352350546914 4395 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_188 3229-0966 278.469 µM -1.29600155965983 0.0939263687443653 no 3040 0.0974874737775654 4401 5722370 SGTC_2400 5203494 178.7 µM -1.2967636887275 0.0937976268813021 no 3041 0.097356254020758 4273 6777674 SGTC_1182 1222-0449 220 µM -1.29836247051493 0.0935279776587928 no 3042 0.097081404485837 4365 658318 SGTC_431 k089-0097 107 µM -1.30220981978797 0.0928814341225293 no 3043 0.0964223346160587 4119 5499420 SGTC_2751 anetholtrithion 17.25 µM -1.30363224383809 0.0926432356705685 no 3044 0.0961795007111409 4338 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2337 9009472 200 µM -1.30512389005396 0.0923939309827406 no 3045 0.0959253325517081 4338 5742383 SGTC_1487 3970-0795 2.82 µM -1.30542773337143 0.0923432093741233 no 3046 0.0958736199673729 4418 3765103 SGTC_2262 9014885 67.46 µM -1.30553002157714 0.0923261386896976 no 3047 0.0958562156501356 4378 6457424 SGTC_1355 1499-0035 1.68 µM -1.30618251108693 0.0922173009157366 no 3048 0.0957452493839079 4366 1548538 SGTC_2460 5552655 174.22 µM -1.30696084211463 0.0920875965369065 no 3049 0.09561300539321 4383 5401989 SGTC_1813 st051246 8.6015 µM -1.30721042510287 0.0920460335839866 no 3050 0.0955706279373287 4313 5291959 SGTC_2991 9074669 71.4286 µM -1.30730396507117 0.0920304599902271 no 3051 0.0955547490625835 4340 17333109 SGTC_1403 3909-7815 62.9 µM -1.30899608261815 0.0917490738787847 no 3052 0.095267838849856 4348 6615483 SGTC_1829 berberine 14.4 µM -1.31035904543118 0.0915228875074936 no 3053 0.0950372007050894 4338 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2608 thymoquinone 42.66 µM -1.31194234248741 0.0912606553994339 no 3054 0.0947697946878932 4333 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3248 9135562 49.47 µM -1.31861088816986 0.0901622964395228 no 3055 0.093649615872191 4348 17650701 SGTC_1980 st071811 45.7 µM -1.31899874793946 0.0900987165658242 no 3056 0.0935847655257381 4444 4974850 SGTC_718 1130-0073 349 µM -1.31967114263727 0.0899885732695075 no 3057 0.0934724193849818 4395 6740020 SGTC_1162 k048-0130 20.1 µM -1.32396442434234 0.0892876595349752 no 3058 0.0927574300689418 4352 6797406 SGTC_2738 aclarubicin 5.55 µM -1.32520075224614 0.0890865739898051 no 3059 0.0925522879718814 4397 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3168 9103419 49.47 µM -1.32986441221246 0.0883310750473501 no 3060 0.0917814743578686 4420 16649256 SGTC_3265 9137266 49.47 µM -1.33099611371847 0.0881484647816996 no 3061 0.0915951448410103 4348 17224265 SGTC_443 clozapine 122 µM -1.3318872022476 0.0880048777439941 no 3062 0.091448628519791 4362 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1935 st074532 41.6 µM -1.33378698662743 0.0876993352073192 no 3063 0.0911368385155655 4355 2829742 SGTC_1341 1486-1360 280 µM -1.33586451247469 0.0873661132000421 no 3064 0.0907967810278879 4374 3976547 SGTC_1557 sumaresinolic acid 42.3 µM -1.33695251203865 0.0871919824790739 no 3065 0.0906190691320318 4366 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1631 benzylvanillin 81.9 µM -1.33723961765345 0.087146075423252 no 3066 0.0905722168990433 4449 75506 SGTC_2717 st081029 62.2815 µM -1.33775917662902 0.0870630458815578 no 3067 0.0904874767516291 4369 5292846 SGTC_1075 aripiprazole 15.2 µM -1.33826415059649 0.0869824037694644 no 3068 0.0904051718431183 4447 60795 An atypical antipschotic. YIL048W NEO1 SGTC_938 3126-1755 342 µM -1.34012791202996 0.0866852522649392 no 3069 0.090101881499273 4398 1777771 SGTC_1956 st077085 54 µM -1.34032254622445 0.086654264284957 no 3070 0.0900702522751656 4419 24208685 SGTC_2030 5175110 200 µM -1.34522030040894 0.0858772090932438 no 3071 0.0892770511849255 4399 2831986 SGTC_1787 fluconazole 80 µM -1.34804356579037 0.0854316586921816 no 3072 0.0888221854050986 4107 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1417 3966-0327 90.4 µM -1.35006363603386 0.0851139277878276 no 3073 0.088497785716945 4482 651118 SGTC_3142 9086498 49.47 µM -1.35287898508248 0.0846725880824938 no 3074 0.0880471470137189 4262 25236367 SGTC_2948 9070189 9.45 µM -1.35470655811632 0.0843870141834413 no 3075 0.0877555338030755 4346 6473636 YDL196W YDL196W SGTC_3036 9090181 49.47 µM -1.3568963517615 0.0840457927014262 no 3076 0.0874070731103057 4460 25236586 SGTC_202 3594-0513 34.79 µM -1.36096573584755 0.0834144395980294 no 3077 0.0867622589208829 4482 708429 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.36264797748919 0.0831544886063997 no 3078 0.0864967402654185 4447 5393153 SGTC_2074 5212007 75.395 µM -1.36358826979184 0.0830094541415041 no 3079 0.086348593005861 4326 758611 SGTC_1662 st014054 52 µM -1.36382304139106 0.0829732717270826 no 3080 0.0863116333093828 4477 2838777 SGTC_3226 9131256 49.47 µM -1.36383864996597 0.0829708665930149 no 3081 0.0863091764972822 4389 17178073 SGTC_1338 1486-1223 76 µM -1.36404099423802 0.0829396919968718 no 3082 0.0862773319517359 4427 3444526 SGTC_88 0180-0332 8.668 µM -1.36410558703419 0.0829297422273163 no 3083 0.086267168314376 4508 3101745 SGTC_1898 st060199 18.6 µM -1.36460821206574 0.082852349358423 no 3084 0.0861881111627537 4388 688866 SGTC_890 0929-0006 47.2 µM -1.3693436048038 0.0821258718306665 no 3085 0.0854459468554564 4411 1378169 SGTC_1614 st002383 48.6 µM -1.37013509310689 0.0820049155972661 no 3086 0.0853223674821228 4442 1947235 SGTC_1667 st014849 34.6 µM -1.37128325195693 0.0818296911778249 no 3087 0.0851433372590335 4493 5348460 SGTC_2395 5646831 180.19 µM -1.37316748729739 0.081542743395555 no 3088 0.0848501423144803 4403 6808628 SGTC_2321 7390090 138.78 µM -1.37322588134298 0.0815338627785259 no 3089 0.0848410680636329 4425 649046 SGTC_3048 9093155 49.47 µM -1.3762152994311 0.0810802032380626 no 3090 0.0843774933922152 4378 25236002 SGTC_2239 6685329 187.64 µM -1.37743889004901 0.0808950674795238 no 3091 0.0841882980490737 4451 805680 SGTC_1362 1611-0397 101 µM -1.37827277830557 0.0807690787317904 no 3092 0.0840595422536698 4405 27816 SGTC_2161 5662504 8.5105 µM -1.37852620038091 0.0807308196031158 no 3093 0.0840204421439249 4378 2859334 SGTC_1788 fluconazole 20 µM -1.38073158367021 0.0803984504608692 no 3094 0.0836807532060864 4430 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3350 9150499 3.57 µM -1.38588127123949 0.0796263778457301 no 3095 0.0828915802817988 4429 4910996 YPR165W RHO1 SGTC_1573 oleylamine 1.06 µM -1.38603249481173 0.0796037905647507 no 3096 0.0828684906753381 4423 5356789 An amine of the fatty acid oleic acid. SGTC_1936 st074407 74.3 µM -1.39024736258422 0.0789761920014681 no 3097 0.082226887874884 4452 809813 SGTC_1997 st073024 93.8 µM -1.39644370854943 0.0780603637959361 no 3098 0.0812904603599341 4475 686268 SGTC_121 0557-0495 61.343 µM -1.39747261907551 0.0779090726218549 no 3099 0.0811357474457788 4477 3104427 SGTC_1285 0929-0069 65.5 µM -1.39822842582781 0.0777980805053239 no 3100 0.0810222416190089 4473 1206237 SGTC_1462 k081-0014 26.5 µM -1.39910865583046 0.0776689678470906 no 3101 0.080890201224591 3873 3270634 SGTC_2429 5902844 64.44 µM -1.40141896633062 0.0773308639575715 no 3102 0.0805444119625384 4420 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2046 4110841 106 µM -1.40346664015823 0.0770321314311945 no 3103 0.080238866543983 4441 44119630 YMR134W ERG29 SGTC_1790 st045711 43.5 µM -1.40678916323574 0.076549280033891 no 3104 0.0797449584569183 4416 585119 SGTC_1442 4112-3290 3 µM -1.40682165012355 0.0765445702122746 no 3105 0.0797401405128428 4438 704353 SGTC_917 harmaline 728.087 nM -1.41076078474566 0.0759751220973932 no 3106 0.0791575805647183 4378 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_881 0833-0569 170 µM -1.4129401821177 0.0756614537152903 no 3107 0.0788366565270592 4468 5418700 SGTC_3275 9138069 49.47 µM -1.41317570270764 0.0756276157188907 no 3108 0.0788020343845198 4500 17617007 SGTC_1855 st056195 39.6 µM -1.41421682587746 0.0754781723440949 no 3109 0.0786491245656556 4365 4028379 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.41687980326378 0.0750969511784293 no 3110 0.0782590361805527 4476 804 An inhibitor of viral and cellular DNA polymerases. SGTC_487 nimodipine 119 µM -1.41717434981451 0.0750548754215914 no 3111 0.0782159795749131 4465 4497 L-type voltage-gated calcium channels inhibitor SGTC_2515 chrysin 20.77 µM -1.41803477463591 0.0749320673395768 no 3112 0.0780903061852279 4451 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1702 st027038 51 µM -1.41872379198351 0.0748338347414409 no 3113 0.0779897790151715 4472 5521182 SGTC_452 diindolylmethane 8 µM -1.4191420502514 0.0747742519677042 no 3114 0.0779288033249143 4445 3071 Inhibits expression of several cancer promoting factors. SGTC_2002 4023503 131 µM -1.42987752396481 0.0732572932758832 no 3115 0.0763760869442925 4434 4736863 YCR052W RSC6 SGTC_1372 2752-0194 270 µM -1.43166310534172 0.0730072844277388 no 3116 0.0761201300363943 4387 823334 SGTC_2024 5144227 134 µM -1.4328708368758 0.0728385540140079 no 3117 0.075947376435629 4432 3475211 SGTC_1410 3909-8106 77.9 µM -1.43575246292597 0.072437172337373 no 3118 0.0755363954734745 4520 1039210 SGTC_2508 celastrol 40.54 µM -1.43798031107448 0.0721280185505091 no 3119 0.0752198203334438 4385 122724 Celastrol is a natural product and antioxidant. SGTC_2093 5331342 194.4 µM -1.44284094529952 0.0714570301589238 no 3120 0.0745326409679558 4492 33839 SGTC_825 1988-2224 89.6 µM -1.45668202612146 0.0695725691153796 no 3121 0.0726020867521886 4448 1180859 SGTC_196 k015-0023 18.111 µM -1.45790315114775 0.0694081675593233 no 3122 0.0724336199757863 4417 5211998 SGTC_1666 st014829 29 µM -1.4583932068525 0.0693422749556376 no 3123 0.0723660960163225 4470 3858230 SGTC_2699 st077704 54.6 µM -1.45865885137933 0.0693065766926822 no 3124 0.0723295134633853 4474 645852 SGTC_143 4032-1194 15.74 µM -1.46566804180332 0.0683697626874448 no 3125 0.0713693723099316 4505 1806963 SGTC_1217 1183-1422 255 µM -1.4666431293962 0.0682402151236267 no 3126 0.0712365804794667 4501 2849664 SGTC_2087 5276107 200 µM -1.46983847052356 0.0678170178971425 no 3127 0.0708027535973554 4448 144405 SGTC_2603 homopterocarpin 100 µM -1.47909776981569 0.066602142475415 no 3128 0.0695570930896438 4456 101795 A weak amylase inhibitor. SGTC_2623 humulene 100 µM -1.48213076911978 0.0662078787596721 no 3129 0.0691527515586685 4468 6187145 An anti-inflammatory. SGTC_329 k048-0121 21.3 µM -1.48309282746744 0.066083197850468 no 3130 0.0690248747021933 4488 6832902 SGTC_1175 0741-0056 27.6 µM -1.48416240403925 0.0659447963984767 no 3131 0.0688829205413116 4545 765927 SGTC_2861 9024595 19.48 µM -1.48715894370223 0.0655582451367976 no 3132 0.0684864183547367 4421 16482810 SGTC_1038 k292-0204 154 µM -1.48787527778884 0.0654660993291649 no 3133 0.0683918942787038 4429 4454212 SGTC_1279 0874-0590 65.2 µM -1.48814700229348 0.0654311722713747 no 3134 0.0683560651362775 4548 3523074 SGTC_3257 9139206 32.98 µM -1.48907540500617 0.0653119458294924 no 3135 0.0682337567699071 4481 4910041 SGTC_270 tamoxifen 5.46 µM -1.4914727183887 0.0650048598103145 no 3136 0.0679187143377409 4501 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3129 9127257 49.47 µM -1.49200589236591 0.0649367149940657 no 3137 0.0678488003188234 4421 837894 SGTC_3175 9106517 49.47 µM -1.49780726847965 0.0641988225549669 no 3138 0.0670916659150467 4504 41468073 SGTC_381 3461-2219 42.7 µM -1.50057695505353 0.0638488451738247 no 3139 0.0667325077674194 4463 2883159 SGTC_1151 3909-8316 15.3 µM -1.5018583410017 0.0636874322424175 no 3140 0.0665668486972389 4536 800431 SGTC_3296 9122258 64.045 µM -1.50186952634478 0.0636860246521814 no 3141 0.066565404045766 4473 4730474 SGTC_2278 7948257 134.34 µM -1.50446410905194 0.0633601696500574 no 3142 0.0662309539909899 4501 1247028 SGTC_2413 inermin 26.06 µM -1.51090101710591 0.0625573591193104 no 3143 0.0654068358479186 4524 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_742 0kpi-0133 140 µM -1.51377868352776 0.0622010316877243 no 3144 0.0650409903988247 4532 2728852 SGTC_2849 9019321 12.99 µM -1.51551109009862 0.0619872808937938 no 3145 0.0648215119895825 4517 16489627 SGTC_2517 totarol 10 µM -1.52390281453725 0.060959981590325 no 3146 0.0637664951451959 4511 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1804 st050076 49.1 µM -1.52535836068969 0.0607831586200661 no 3147 0.0635848692880761 4534 3895976 SGTC_1027 k015-0025 8.67 µM -1.52608931780336 0.0606945117496632 no 3148 0.0634938110145923 4482 3598955 SGTC_1950 st077106 7.18 µM -1.52868333079198 0.0603807386160402 no 3149 0.0631714833175513 4418 13831864 SGTC_1701 st028638 40.4 µM -1.52971808824719 0.060255928582057 no 3150 0.063043262174029 4529 3490878 SGTC_3225 9130819 49.47 µM -1.53027603073724 0.0601887147079017 no 3151 0.0629742093432008 4465 4547121 SGTC_1471 k673-0312 37 µM -1.53153265122156 0.0600375478894197 no 3152 0.0628189015755748 4497 24099884 SGTC_2778 tioconazole 65.09 nM -1.53972628996883 0.0590591608710668 no 3153 0.0618135428474991 4415 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3331 9141060 1.957 µM -1.53974190816633 0.0590573079466974 no 3154 0.0618116385605001 4454 4906567 YPR165W RHO1 SGTC_1901 st060216 58.6 µM -1.53991080880146 0.0590372726893284 no 3155 0.0617910478619844 4482 688792 SGTC_1022 4477-0945 21.3 µM -1.54078954191069 0.0589331220135916 no 3156 0.0616840077758382 4463 4648966 SGTC_2873 9040596 71.43 µM -1.54159694433864 0.0588375528462839 no 3157 0.0615857842837845 4481 6463863 SGTC_442 cape 100 µM -1.5416120436377 0.0588357667586044 no 3158 0.0615839485623043 4543 5281787 SGTC_1796 st049173 110.4 µM -1.54510632720719 0.0584235729237037 no 3159 0.0611602734026805 4509 94134 SGTC_2975 9084847 53.72 µM -1.54668319278168 0.0582383063647838 no 3160 0.0609698289341421 4512 27211724 SGTC_2063 5246145 200 µM -1.54804793310583 0.0580783353375059 no 3161 0.0608053782170603 4558 711240 SGTC_1866 st057638 64 µM -1.54895400773896 0.057972318677988 no 3162 0.0606963882790553 4537 688802 SGTC_1421 4029-0249 71.4 µM -1.5553194102467 0.0572318069325863 no 3163 0.0599350084050461 4595 2894095 SGTC_2125 5246583 200 µM -1.55830512657619 0.0568870416173147 no 3164 0.0595804671376022 4525 835267 SGTC_2829 7992743 58.44 µM -1.55897493866089 0.0568099224377543 no 3165 0.0595011559403112 4503 16462845 SGTC_737 1950-0117 57.9 µM -1.56035617645978 0.0566511528579422 no 3166 0.059337867438379 4535 5393513 SGTC_274 sirtinol 40.1 µM -1.5626110544478 0.0563927120799075 no 3167 0.0590720532900766 4561 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_478 N-arachidonylglycine 10 µM -1.56441150287861 0.0561870233028819 no 3168 0.0588604805331445 4566 5283389 SGTC_2226 7298446 200 µM -1.56623234232998 0.0559796070902511 no 3169 0.0586471168340221 4542 3283010 SGTC_540 1187-0821 17.3 µM -1.56811722153918 0.0557655326284883 no 3170 0.0584268890700482 4453 847520 SGTC_2266 7929956 200 µM -1.56813175209091 0.0557638848391247 no 3171 0.0584251938582075 4477 2967153 SGTC_786 4544-0069 423 µM -1.5726665601581 0.0552515041750538 no 3172 0.0578980233678244 4520 748821 YLR208W SEC13 SGTC_559 1550-0661 158 µM -1.57907502627852 0.0545337706397972 no 3173 0.0571594245859814 4574 5830875 SGTC_1158 4092-0494 91.8 µM -1.58095969406172 0.0543241011825168 no 3174 0.0569436269493574 4607 1148199 SGTC_2851 9015922 71.43 µM -1.58377884722041 0.0540116612375278 no 3175 0.0566220272729944 4546 2996893 SGTC_1311 1190-0148 100 µM -1.58444805624158 0.053937703725232 no 3176 0.0565458966772577 4571 1961333 SGTC_2212 7123476 200 µM -1.58570599893998 0.0537988994385425 no 3177 0.0564030088551991 4587 1085715 SGTC_91 0417-1751 58.384 µM -1.58904176300657 0.0534321929465188 no 3178 0.0560254821569802 4622 6795624 SGTC_3349 9149703 23.001 µM -1.59046977657652 0.0532758155740156 no 3179 0.0558644764939617 4553 4910494 SGTC_579 4491-1009 110 µM -1.5925339006556 0.0530504211008042 no 3180 0.055632396078868 4607 1271041 SGTC_3251 9135047 49.47 µM -1.59456624722685 0.0528292360605929 no 3181 0.0554046327260904 4589 17682963 SGTC_2711 st079103 59.1 µM -1.5956431868934 0.0527123270856006 no 3182 0.0552842398132249 4475 54693780 SGTC_396 dithiazanine 1.25 µM -1.59569036949176 0.0527072097979004 no 3183 0.0552789699185361 4503 10578 An antihelmenthic. SGTC_2932 9016711 44.54 µM -1.59684085137874 0.0525825538174114 no 3184 0.0551505936219235 4520 7117328 SGTC_354 2783-3500 4.88 µM -1.59699535531859 0.052565830981409 no 3185 0.0551333712824004 4523 6740761 SGTC_2876 9059903 25.97 µM -1.59907546349526 0.0523410998211586 no 3186 0.0549019179323855 4536 6916095 SGTC_2064 5220758 200 µM -1.60618757172711 0.0515784788406748 no 3187 0.054116351618192 4569 788518 SGTC_1885 st057546 99.9 µM -1.60625189830231 0.0515716217300419 no 3188 0.0541092872513406 4577 702008 SGTC_2129 girgensonine 121.053 µM -1.6081155164727 0.051373277505765 no 3189 0.053904940749523 4531 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1691 st019933 84.6 µM -1.61145582137986 0.0510192888868662 no 3190 0.0535402044490295 4547 6176082 SGTC_11 0438-0307 1.3 µM -1.61393319212269 0.0507580056795567 no 3191 0.0532709590621889 4549 4011476 SGTC_2442 5158906 48.48 µM -1.61424317260807 0.0507253878126964 no 3192 0.0532373454708898 4547 1893835 SGTC_533 1222-0222 6.71 µM -1.6249687557398 0.049607027690998 no 3193 0.0520846082090938 4572 3982874 SGTC_1867 st057372 64 µM -1.62720545005272 0.0493763048149029 no 3194 0.0518467353136853 4535 688837 SGTC_1916 st067606 49.2 µM -1.6301754476845 0.0490712640677679 no 3195 0.0515322107366396 4460 19590279 SGTC_3180 9109287 49.47 µM -1.63066478328754 0.0490211504246373 no 3196 0.0514805356818563 4586 18891271 SGTC_1523 st012844 44.7 µM -1.63140476498669 0.0489454453827165 no 3197 0.05140247006284 4591 4274103 SGTC_166 k072-0058 166.424 µM -1.63257979128415 0.0488254243511959 no 3198 0.0512787021709797 4434 5846229 SGTC_3194 9111903 49.47 µM -1.6336619090671 0.0487151014465243 no 3199 0.0511649303351581 4547 17087251 SGTC_336 4111-0029 111 µM -1.63621450567982 0.0484556511837453 no 3200 0.0508973508000644 4578 3131175 SGTC_1962 st076595 64.5 µM -1.64516589157532 0.0475545386032199 no 3201 0.0499678026580381 4528 279619 SGTC_2980 9014342 25.29 µM -1.64525281944792 0.0475458540694438 no 3202 0.0499588425410836 4584 2996599 SGTC_468 gf-109203x 121 µM -1.64539118582041 0.0475320331902005 no 3203 0.0499445830280923 4645 2396 A protein kinase C inhibitor. SGTC_26 0302-0163 425.158 µM -1.65959607590727 0.0461302010875361 no 3204 0.0484978691475138 4631 3100915 SGTC_1215 3852-0577 11.2 µM -1.66708026872867 0.0454050796266341 no 3205 0.0477492225020206 4600 2884876 SGTC_1756 st041558 35.5 µM -1.67317240166132 0.0448216233633267 no 3206 0.0471466808585886 4648 3955792 SGTC_1961 st076550 68.7 µM -1.67490851940095 0.0446564615996275 no 3207 0.046976090916588 4576 1579337 SGTC_415 dibenzyl ketone 100 µM -1.6805620424941 0.0441220205769066 no 3208 0.0464240069029482 4559 7593 SGTC_372 0155-0182 15.9 µM -1.68067988158661 0.0441109360705596 no 3209 0.0464125552036431 4470 771486 SGTC_1671 st016596 74.5 µM -1.68310121828881 0.0438836702311263 no 3210 0.0461777493482366 4629 2829167 SGTC_180 1486-1293 102.781 µM -1.68432085797197 0.0437695534563841 no 3211 0.0460598382538615 4509 4140536 SGTC_1886 st057356 49.9 µM -1.68467020665681 0.0437369104524024 no 3212 0.0460261088694864 4566 24207747 SGTC_2189 6047310 154.431 µM -1.684776594338 0.0437269735317263 no 3213 0.0460158411515598 4595 711535 SGTC_672 1441-0018 53.7 µM -1.68567162161037 0.0436434474710544 no 3214 0.0459295328687096 4587 251141 SGTC_550 4123-0385 25.7 µM -1.68817824860694 0.0434102081602183 no 3215 0.0456885086589282 4604 5731123 SGTC_642 0335-0876 158 µM -1.69655981470791 0.0426376105004811 no 3216 0.044889956317541 4628 6812350 SGTC_721 1187-1332 279 µM -1.69986025699687 0.0423364488546862 no 3217 0.0445786070202486 4591 25730 SGTC_3215 9129942 49.47 µM -1.70427244797075 0.041936531844948 no 3218 0.0441650998990954 4555 17682944 SGTC_731 3966-0296 387 µM -1.70448734062915 0.0419171325419833 no 3219 0.0441450395597562 4606 660956 SGTC_2185 6113692 200 µM -1.70520520320182 0.0418523806072767 no 3220 0.0440780799733079 4584 874150 SGTC_2653 dihydrofissinolide 100 µM -1.70782031765952 0.0416171792760225 no 3221 0.0438348439512505 4670 6857746 SGTC_2917 7979103 53.79 µM -1.71573784410924 0.0409116051631073 no 3222 0.0431050174644656 4582 2980565 SGTC_2556 citropten 84.59 µM -1.71728340881275 0.0407750099179444 no 3223 0.0429637009834171 4576 2775 A potential DNA crosslinker. SGTC_3114 9122766 49.47 µM -1.72233293892307 0.0403313157674022 no 3224 0.0425046120528835 4583 17176985 SGTC_418 lividomycin a 100 µM -1.73269171558013 0.0394333780864898 no 3225 0.0415752388870318 4619 72394 An antibiotic. SGTC_52 0329-0193 875 nM -1.73954245840548 0.0388485145974894 no 3226 0.0409696953260476 4626 3739292 SGTC_258 haloperidol 50.781 µM -1.74206997717285 0.0386345267443652 no 3227 0.0407481001381352 4584 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2792 7535235 81.82 µM -1.74442267061552 0.0384362041666577 no 3228 0.04054270735509 4568 1281891 SGTC_1284 0929-0043 16 µM -1.74861358492614 0.0380849830767234 no 3229 0.0401789182261666 4612 1239883 SGTC_628 1636-0253 16 µM -1.75168415597354 0.0378293179700077 no 3230 0.0399140663862202 4604 4456143 SGTC_3080 9117754 49.47 µM -1.75489460913305 0.0375635054326292 no 3231 0.0396386682261429 4613 9550191 SGTC_1443 4112-3303 14 µM -1.7581733627394 0.0372936139694003 no 3232 0.0393590080498128 4650 704433 SGTC_2142 5622915 118.518 µM -1.76165529620588 0.0370087343514003 no 3233 0.0390637775770174 4622 5322196 SGTC_1270 0831-1170 17.3 µM -1.76499657655139 0.0367370374109038 no 3234 0.0387821705385483 4628 6764716 SGTC_1163 k060-0048 49.9 µM -1.76977982099284 0.0363509282491103 no 3235 0.0383819133477851 4632 6809982 SGTC_122 0236-0016 402.397 µM -1.77299093088127 0.0360935917884221 no 3236 0.0381151048334778 4597 6808838 SGTC_1567 st069303 68.4 µM -1.7777901836621 0.0357117652809256 no 3237 0.0377191606578139 4609 5581319 SGTC_1379 2144-0755 36.5 µM -1.77944000572792 0.0355812732088727 no 3238 0.0375838262775556 4642 5392327 SGTC_2467 5474540 200 µM -1.78130996012582 0.035433842707532 no 3239 0.0374309141286367 4606 5413519 SGTC_1409 3909-8004 61.9 µM -1.78289016525069 0.0353096473947128 no 3240 0.037302092165559 4652 2119279 SGTC_537 1334-0398 209 µM -1.789607787608 0.0347856586903073 no 3241 0.0367584928419508 4634 5846986 SGTC_203 k066-0004 30.888 µM -1.79968443691751 0.0340116451008881 no 3242 0.0359552399448436 4666 6795412 SGTC_2099 5377090 177.372 µM -1.82330603629406 0.0322526217188266 no 3243 0.0341285262945775 4624 2243829 SGTC_581 0958-0271 211 µM -1.82970980073208 0.0317889082887531 no 3244 0.0336466722962419 4642 4591145 SGTC_547 1120-0019 610 nM -1.83377251887409 0.0314975819510131 no 3245 0.0333438843327654 4611 3676939 SGTC_2268 7933382 153.85 µM -1.83716957940717 0.031255685494233 no 3246 0.033092432511078 4660 935025 YOR257W CDC31 SGTC_3084 9116877 49.47 µM -1.84457652292058 0.0307335798173051 no 3247 0.0325495823778474 4601 27241325 SGTC_1277 0873-0036 22 µM -1.85047477796275 0.0303230026156555 no 3248 0.0321225750043833 4677 5965735 SGTC_1281 0884-0031 11.8 µM -1.85123949712904 0.0302701049523053 no 3249 0.03206755294868 4659 1548255 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.85794327975964 0.029809652473003 no 3250 0.0315885347242165 4665 165506 SGTC_623 k072-0108 16.9 µM -1.87860504765206 0.0284269048865295 no 3251 0.0301492207108939 4634 5382803 SGTC_2439 5492030 7.2 µM -1.88005869136574 0.0283316659585199 no 3252 0.0300500397428816 4651 5722370 SGTC_865 0488-0499 301 µM -1.88303831881086 0.0281372784530933 no 3253 0.0298475875910751 4602 9634651 SGTC_2252 omeprazole 400 µM -1.88576113448754 0.0279606172711929 no 3254 0.0296635752384808 4684 4594 A proton pump inhibitor. SGTC_2831 7999036 19.48 µM -1.88821970254129 0.0278018955706944 no 3255 0.0294982309231168 4609 2988270 SGTC_2552 juarezic acid 87.02 µM -1.89177012574817 0.0275740106172711 no 3256 0.0292608076481409 4617 1549512 SGTC_2347 9049783 174.81 µM -1.89238100542141 0.0275349585602175 no 3257 0.0292201174781539 4627 6467988 YPL169C MEX67 SGTC_416 estradiol valerate 100 µM -1.8937536993159 0.0274473737587856 no 3258 0.0291288549658887 4641 13791 A steroid. SGTC_1026 k007-1105 30.6 µM -1.89396880829989 0.0274336697956314 no 3259 0.0291145750930868 4621 7066794 SGTC_2127 5253358 187.912 µM -1.89865136552595 0.0271367687947774 no 3260 0.0288051650117467 4595 20612 SGTC_1682 st012968 530 nM -1.90795948194869 0.0265545395514708 no 3261 0.0281982266753168 4616 24207270 SGTC_1768 st044301 37.178 µM -1.90939175808663 0.0264658829583251 no 3262 0.0281057866051762 4669 3931349 SGTC_2408 sulbentine 18.36 µM -1.91466709192542 0.0261414750414798 no 3263 0.0277674864519715 4531 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_900 1112-0045 141 µM -1.91563695325087 0.0260821965308379 no 3264 0.0277056612528353 4609 56211 YIL048W NEO1 SGTC_45 0kpi-0036 14.9 µM -1.91758313912136 0.025963583580131 no 3265 0.0275819448804227 4618 2795021 SGTC_2995 9067767 71.4286 µM -1.91875287216452 0.0258925099647429 no 3266 0.0275078083644455 4641 11673567 SGTC_2891 9063876 19.48 µM -1.92022873281593 0.0258030682049821 no 3267 0.0274145068974552 4688 6472478 SGTC_1760 st045453 10.4495 µM -1.92397610398746 0.025577126939842 no 3268 0.0271787894002694 4663 3323419 YIL048W NEO1 SGTC_1896 st058441 89 µM -1.93293954960273 0.0250434039961604 no 3269 0.0266218225289028 4669 688759 SGTC_2860 9025725 38.96 µM -1.94575538426741 0.0242965350776141 no 3270 0.0258420651396548 4695 40546248 SGTC_920 mycophenolic acid 780.421 nM -1.94956104153935 0.0240783877266367 no 3271 0.0256142303203352 4652 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2290 7904846 200 µM -1.95373195672028 0.0238411955135167 no 3272 0.0253664624669696 4695 2962154 SGTC_1080 nisoldipine 24.4 µM -1.9718352008762 0.0228343393301472 no 3273 0.0243142112486153 4710 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_206 4546-0025 72.014 µM -1.97612463007687 0.0226010944622534 no 3274 0.0240703317406082 4677 6620745 YIL048W NEO1 SGTC_1988 st071872 53.4 µM -1.98082308678722 0.0223479162355898 no 3275 0.0238055584063687 4702 16414116 SGTC_42 0133-0086 60.653 µM -1.98695232802626 0.0220212394044717 no 3276 0.0234638399785699 4594 162923 Model of phenazepam hydroxylation. SGTC_3116 9124943 49.47 µM -1.99103037617256 0.0218061280516731 no 3277 0.0232387739153936 4658 41905195 YPL160W CDC60 SGTC_316 k060-0003 58.6 µM -1.99518454090692 0.0215888291552766 no 3278 0.0230113782330803 4708 6152314 SGTC_85 0868-0259 160.055 µM -2.00862019374122 0.0208985174845484 no 3279 0.02228871403634 4646 83173 SGTC_1491 4138-0063 26.5 µM -2.00957294481719 0.0208502835714353 no 3280 0.0222382035614478 4720 23883227 SGTC_1994 st072947 40.9 µM -2.00961095527217 0.0208483612132252 no 3281 0.0222361904272357 4702 5286565 YDL195W SEC31 SGTC_1513 0337-0559 19 µM -2.01840651123525 0.0204075469214556 no 3282 0.0217744709114096 4657 775073 SGTC_1048 3161-0300 24.5 µM -2.02772924748376 0.0199489604282715 no 3283 0.0212939444496433 4691 2165101 SGTC_335 4077-0256 27.6 µM -2.03009663487652 0.0198339102755657 no 3284 0.0211733587629311 4600 3121989 SGTC_992 3909-8734 162 µM -2.05522837816818 0.0186468936207251 no 3285 0.0199284756826369 4703 4288319 SGTC_516 3992-2719 87.3 µM -2.08566978711375 0.017290576487034 no 3286 0.0185042725103465 4616 5350887 YDR037W KRS1 SGTC_2978 9011784 42.97 µM -2.0865167638613 0.0172540772801597 no 3287 0.0184659191467615 4686 2994934 SGTC_3153 9100258 49.47 µM -2.0949752234821 0.0168931694428277 no 3288 0.0180865975181046 4630 25236848 SGTC_717 1532-0246 73.2 µM -2.09868956432815 0.0167367363328064 no 3289 0.01792213759922 4692 9561992 SGTC_2767 sibutramine 71.45 µM -2.10404975431409 0.0165131721557139 no 3290 0.0176870535675087 4696 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1634 st006576 41 µM -2.10534351455709 0.0164595962333569 no 3291 0.0176307084315272 4672 3915356 SGTC_1469 k284-2957 126 µM -2.11123586016595 0.0162174665428978 no 3292 0.0173760219815609 4726 23884841 SGTC_3157 9099274 49.47 µM -2.11444237235186 0.016086990461703 no 3293 0.0172387509280195 4712 17217662 SGTC_1938 st074717 56.4 µM -2.12354257692676 0.0157215831370062 no 3294 0.0168542058081708 4625 17250979 SGTC_74 000s-0487 160.283 µM -2.12455536878847 0.0156813594998027 no 3295 0.0168118656664356 4628 677548 SGTC_3132 9126706 49.47 µM -2.16100862676388 0.0142912245688759 no 3296 0.0153473365163827 4709 850858 SGTC_955 1216-0110 33 µM -2.16733488869365 0.0140611098200651 no 3297 0.01510466403541 4691 3619719 SGTC_1937 st074714 47.2 µM -2.19013280645824 0.0132581408743767 no 3298 0.0142573033005667 4687 17250970 SGTC_2997 9067075 71.4286 µM -2.19345815797695 0.0131443931475738 no 3299 0.0141371930388012 4690 27209819 SGTC_2684 capsaicin 100 µM -2.19482355114392 0.0130979329981892 no 3300 0.0140881287026877 4753 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2867 9039098 71.43 µM -2.2041619223802 0.0127839654765145 no 3301 0.0137564793009573 4709 6463460 SGTC_2739 tacrine 100.86 µM -2.21674320556547 0.012371275593837 no 3302 0.0133203222640259 4749 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_957 1187-1561 14.1 µM -2.23042648055239 0.0119355867180998 no 3303 0.012859571607099 4682 1538454 SGTC_1096 rimcazole 32.2 µM -2.24943262511462 0.0113525263012595 no 3304 0.01224249243492 4729 18528119 A dopamine reuptake inhibitor. SGTC_956 1185-0240 191 µM -2.2742103684208 0.0106296816330165 no 3305 0.0114766705724708 4716 1416193 SGTC_2971 9092186 9.93 µM -2.31198365217983 0.00960487250555903 no 3306 0.0103892921115662 4691 25236400 SGTC_1178 0988-0033 191 µM -2.31719880199918 0.00947039502301189 no 3307 0.0102464523824945 4759 5392207 SGTC_1045 1348-1485 165 µM -2.32260436941651 0.0093327480080847 no 3308 0.0101002078906526 4714 6810614 SGTC_2406 ethylparaben 405.7 µM -2.32671295281542 0.00922930117986312 no 3309 0.00999027399953232 4691 8434 A possible steroid mimic. SGTC_3264 9137442 49.47 µM -2.32976532964327 0.00915309882655007 no 3310 0.00990927876763277 4709 17015726 SGTC_1527 coumarin 137 µM -2.34856742009114 0.00869574084065273 no 3311 0.00942289351803866 4743 323 A hepatotoxic, DNA x-linker. SGTC_77 0828-0286 12.516 µM -2.35459635463722 0.00855339322370858 no 3312 0.00927141781701566 4671 745345 SGTC_2881 9058953 51.95 µM -2.35716808471883 0.00849329747785725 no 3313 0.00920745471800464 4719 17122249 SGTC_1047 2043-3044 82 µM -2.39070880315835 0.00774279414599697 no 3314 0.00840794209512089 4724 669592 SGTC_3351 9150312 21.596 µM -2.39485497739163 0.00765419798311153 no 3315 0.00831347008694547 4714 4904905 SGTC_3015 9080845 49.47 µM -2.39600403962568 0.00762980310360043 no 3316 0.00828745382238674 4765 5296973 SGTC_2779 methotrexate 400 µM -2.39786563782399 0.0075904261810763 no 3317 0.00824545655786922 4725 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_78 0336-0123 156.75 µM -2.42542037534403 0.00702816227713906 no 3318 0.00764533479043619 4688 6765896 SGTC_1983 st071813 46.9 µM -2.42819505930202 0.00697363407714266 no 3319 0.00758708984485763 4778 11838595 SGTC_1129 3453-1384 223 µM -2.43539556234721 0.00683386791220374 no 3320 0.0074377590365812 4713 1084452 SGTC_3144 9087057 49.47 µM -2.43956056957546 0.00675415713980918 no 3321 0.00735256864373728 4703 17249618 SGTC_3108 9121785 49.47 µM -2.46335921735995 0.0063142600620564 no 3322 0.00688209689090602 4689 17140271 SGTC_2986 9022445 71.43 µM -2.49152652589196 0.00582653404757765 no 3323 0.00635977344766323 4748 6459286 SGTC_933 2914-0560 114 µM -2.49690125478383 0.00573736201066414 no 3324 0.00626419190827218 4748 463887 SGTC_1932 st074806 40.9 µM -2.50275818975628 0.00564157075391082 no 3325 0.00616148531103646 4758 17251235 SGTC_2960 9079389 5.97 µM -2.50424930555814 0.00561741121433015 no 3326 0.00613557667303887 4735 16457355 SGTC_194 1486-1323 56.904 µM -2.52778278748617 0.005248096513607 no 3327 0.00573926714638482 4791 5178754 SGTC_2341 7987486 176.74 µM -2.52782409466238 0.00524746773061369 no 3328 0.00573859198086805 4762 1258686 SGTC_3150 9097574 49.47 µM -2.55789823454139 0.00480707799423461 no 3329 0.00526534522601542 4777 17217476 SGTC_2908 7930301 100 µM -2.5698681549144 0.00464117263045682 no 3330 0.00508686133190587 4722 2223178 SGTC_2543 pimpinellin 60.67 µM -2.58383388140179 0.00445407775096655 no 3331 0.00488544215049893 4703 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1357 1503-1303 39.5 µM -2.62077098936363 0.00399130012261621 no 3332 0.00438655868929449 4761 292895 SGTC_3213 9129884 49.47 µM -2.62903610221375 0.0038938388882951 no 3333 0.00428136349856793 4746 17190742 SGTC_735 3076-0345 636 µM -2.6389495718893 0.00377975663758328 no 3334 0.00415816752932241 4779 2888990 SGTC_3016 9080866 49.47 µM -2.64232387874765 0.00374161491889601 no 3335 0.00411696381730484 4771 17066299 SGTC_3011 9081274 71.4286 µM -2.64269517118746 0.00373743913876368 no 3336 0.00411245234656845 4777 6625322 SGTC_2481 5478948 45.16 µM -2.64545878574384 0.00370648895094439 no 3337 0.00407901121711655 4761 77792 SGTC_3119 9125183 49.47 µM -2.69399493557085 0.00319912943173077 no 3338 0.00353006187302399 4768 22695334 SGTC_421 streptovitacin 30 mM -2.88278641377986 0.00176701521092302 no 3339 0.00197087305105927 4776 91467 include heat shock SGTC_439 amiodarone 34.4 µM -2.93367733542926 0.00149712459533389 no 3340 0.00167486118996383 4733 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1749 st037932 54.2 µM -2.96031022151907 0.00137139986810143 no 3341 0.00153664701791199 4770 594497 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.97971291763362 0.00128596328834268 no 3342 0.00144259320559684 4773 521171 SGTC_2756 carbadox 75.1 µM -2.98542272219888 0.00126176447779424 no 3343 0.00141593340414003 4748 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2012 4023501 200 µM -3.01239259651413 0.00115299560115504 no 3344 0.00129598569550689 4778 3477460 SGTC_2008 4012253 172 µM -3.08243064745936 0.000909411001858466 yes 3345 0.00102658783393866 4782 603940 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -3.10089059484022 0.000853607703550412 yes 3346 0.000964697813929894 4797 2333 A French combination drug. SGTC_2082 5219693 150 µM -3.13984647948056 0.000746036682628638 yes 3347 0.000845181961863229 4778 2834649 SGTC_2944 9067346 25.62 µM -3.14190343480521 0.000740719792625109 yes 3348 0.000839266926640768 4765 6473075 SGTC_712 r015-0009 80.6 µM -3.14793691310638 0.000725325000483929 yes 3349 0.00082213587919054 4798 6813872 YLR060W FRS1 SGTC_2835 9006588 71.43 µM -3.45077415806522 0.000241737733797448 yes 3350 0.000279490555506816 4768 2345538 SGTC_2921 7974240 10.71 µM -3.48671605944093 0.000210950764167626 yes 3351 0.00024449511010475 4799 2979074 YDR527W RBA50 SGTC_2065 5221596 34.26 µM -4.07274982955155 1.91980503465177e-05 yes 3352 2.32306604449134e-05 4805 788581 SGTC_675 1309-0189 238 µM -4.15798205594149 1.31776042973259e-05 yes 3353 1.60535618555574e-05 4807 4246530 SGTC_2957 9076800 11.52 µM -5.10461171547368 1.25191128484844e-07 yes 3354 1.6573720443999e-07 4807 16459615