SGTCid condition conc unit DAL81|YIR023W.score DAL81|YIR023W.strain.pval DAL81|YIR023W.strain.significant DAL81|YIR023W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2460 5552655 174.22 µM 41.5889060507761 3.37269025370966e-120 yes 1 0 1 5401989
SGTC_2845 9003024 42.97 µM 39.3331576064004 9.99385396343462e-108 yes 2 0 1 2990173
SGTC_486 niguldipine 82 µM 35.4636373442743 5.99088496938362e-88 yes 3 8.93931417161372e-276 1 1236 A calcium channel blocker.
SGTC_990 3985-0011 41.3 µM 26.3989933750111 1.31432119974809e-49 yes 4 7.03561073520617e-154 1 5399565 YGL099W LSG1
SGTC_337 1315-0038 354 µM 25.4744028015004 2.5158696459756e-46 yes 5 1.89443664940223e-143 1 1626437
SGTC_1058 3448-5425 97.3 µM 21.5458946675432 1.12061652528435e-33 yes 6 2.89275574006296e-103 1 7279705
SGTC_2093 5331342 194.4 µM 21.0378163924153 3.40581795814801e-32 yes 7 1.47841843962036e-98 1 33839
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 20.9933064613543 4.57560901981639e-32 yes 8 3.77531020367782e-98 1 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1056 3448-1962 115 µM 20.4531593476449 1.56716883144389e-30 yes 9 2.81538149835915e-93 1 715507
SGTC_569 4130-2812 160 µM 19.0819006028229 8.1916304686094e-27 yes 10 1.78518253071388e-81 1 743552
SGTC_2833 9001315 45.46 µM 18.8421373455828 3.44603712721576e-26 yes 11 1.70458401023357e-79 1 2989378
SGTC_700 3453-2283 142 µM 18.2999198008922 8.31072656363031e-25 yes 12 4.1435391644469e-75 1 565664
SGTC_581 0958-0271 211 µM 17.7936732827259 1.49386062921176e-23 yes 13 3.95595409386991e-71 1 4591145
SGTC_2090 5301565 104.445 µM 17.7050159333184 2.45734585612083e-23 yes 14 1.9178606491229e-70 2 2056344
SGTC_161 4065-0411 162.148 µM 16.5894576241915 1.04576632425803e-20 yes 15 4.15335537788571e-62 1 1906281 YLR208W SEC13
SGTC_2618 avocadyne 43.43 µM 16.0141958446597 2.0387355632724e-19 yes 16 5.0856608841591e-58 8 3015189
SGTC_2137 5261020 140 µM 15.4987865044443 2.67368307821184e-18 yes 17 1.76752927491752e-54 3 763655
SGTC_823 0417-1665 178 µM 15.3191464782687 6.43073191173107e-18 yes 18 2.84802796516855e-53 2 3429856
SGTC_3237 9133362 49.47 µM 15.1627878607516 1.36920632449559e-17 yes 19 3.11824696651733e-52 1 43845137
SGTC_2980 9014342 25.29 µM 15.0617803955874 2.22196674616246e-17 yes 20 1.44450387831893e-51 2 2996599
SGTC_1759 st043059 70 µM 14.9148834817294 4.46764773667001e-17 yes 21 1.31868627050654e-50 1 669426
SGTC_1181 1222-0449 220 µM 14.9128048212449 4.51180648309226e-17 yes 22 1.36039481371473e-50 1 658318
SGTC_2976 9009005 19.48 µM 14.782141820813 8.35000743867327e-17 yes 23 9.54972819686604e-50 4 2993148
SGTC_3303 9125618 40.5795 µM 14.7679456292748 8.92469987751476e-17 yes 24 1.17895584012005e-49 2 22695467
SGTC_2932 9016711 44.54 µM 14.6055905409217 1.90219208761544e-16 yes 25 1.29365303054205e-48 3 7117328
SGTC_933 2914-0560 114 µM 14.4380458340533 4.11808906810477e-16 yes 26 1.49088418454969e-47 3 463887
SGTC_1824 st053723 68.6 µM 14.240133178865 1.01406091904953e-15 yes 27 2.58142858128803e-46 2 675225
SGTC_974 1326-0144 138 µM 14.1936376021165 1.2509580123017e-15 yes 28 5.01585605857036e-46 2 5411856
SGTC_639 0833-0042 114 µM 13.8065333239933 6.99940375733537e-15 yes 29 1.16383245367577e-43 2 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3225 9130819 49.47 µM 13.6998289699783 1.11596143788942e-14 yes 30 5.08818568009121e-43 1 4547121
SGTC_253 dyclonine 31.25 µM 13.2242496089694 8.54981258829505e-14 yes 31 3.17842387439914e-40 1 3180 An oral anasthetic.
SGTC_878 0828-0289 13.7 µM 13.1677051051526 1.08411313336353e-13 yes 32 6.73139603548967e-40 3 745350 YLR208W SEC13
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 12.7852451275693 5.2634831717366e-13 yes 33 9.91183975896737e-38 2 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2461 5755302 26.15 µM 12.7793607870515 5.39109896066509e-13 yes 34 1.06909787843565e-37 2 2788904
SGTC_3330 9141424 71.43 µM 12.6643227531866 8.59293671118313e-13 yes 35 4.66106998057332e-37 1 27261020
SGTC_867 0518-0118 155 µM 12.6397987154607 9.48579325403208e-13 yes 36 6.36898104630673e-37 1 6848158
SGTC_3228 9131799 49.47 µM 12.4643692800563 1.91350129755314e-12 yes 37 5.83960823135845e-36 1 17015818
SGTC_2254 7938975 95.19 µM 12.3212780349797 3.36782147725519e-12 yes 38 3.47913575199289e-35 8 2969277
SGTC_325 2810-4341 181 µM 12.180149799016 5.84536834074302e-12 yes 39 1.98276422687509e-34 1 774970
SGTC_1187 1391-0724 117 µM 12.1605133687539 6.30839516095551e-12 yes 40 2.52203520014534e-34 1 6997986
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 12.1096264232551 7.68199028123573e-12 yes 41 4.69604708908058e-34 1 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_592 k241-0073 46.5 µM 11.9204643473442 1.58659021075452e-11 yes 42 4.62955192261935e-33 2 4230158
SGTC_2841 9004761 38.96 µM 11.8545076609867 2.03783160405957e-11 yes 43 1.01959625553322e-32 1 2991039
SGTC_562 3772-2733 112 µM 11.559750685044 6.135384401813e-11 yes 44 3.29499196311456e-31 6 2876874 YIL048W NEO1
SGTC_1173 0443-0020 122 µM 11.1826359976427 2.41721200484819e-10 yes 45 2.47973128343899e-29 4 5331295
SGTC_2255 7941087 197.44 µM 11.1318068484125 2.89815457703924e-10 yes 46 4.39183696150552e-29 3 935561
SGTC_389 tpck 16.7 µM 10.9552019789013 5.41068198570914e-10 yes 47 3.13691268438999e-28 3 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2642 cholecalciferol 100 µM 10.8672312042858 7.35790917045236e-10 yes 48 8.25682099896675e-28 6 9821465 A vitamin D precursor, similar to steriods.
SGTC_1958 st076513 41.9 µM 10.6066092741874 1.8038811479581e-09 yes 49 1.38821245438155e-26 1 732122 YGL099W LSG1
SGTC_1726 st035556 14.5795 µM 10.5708488804389 2.03675542818167e-09 yes 50 2.03397810524419e-26 5 5919439
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 10.5021435202686 2.5690407661679e-09 yes 51 4.22202772985946e-26 1 5355888
SGTC_825 1988-2224 89.6 µM 10.3197314552378 4.72528537631232e-09 yes 52 2.86917146529536e-25 5 1180859
SGTC_1853 st056710 91.2 µM 10.2592552345264 5.77023442959376e-09 yes 53 5.3766437307268e-25 1 269167
SGTC_744 1594-0068 283 µM 10.230928684322 6.33382747826314e-09 yes 54 7.20652599934301e-25 1 668392
SGTC_87 0100-0052 35.5 µM 10.0784096072775 1.04171604882501e-08 yes 55 3.4415584824673e-24 6 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_129 0088-0017 176.636 µM 10.0773303048206 1.04536376653327e-08 yes 56 3.47956250892059e-24 10 182446
SGTC_2232 chlorophetanol 41.5365 µM 10.0212905605888 1.25278648595702e-08 yes 57 6.14438409528405e-24 11 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_845 0330-0138 4.51 µM 9.91602195923137 1.75555163589268e-08 yes 58 1.7730432158415e-23 3 9039800
SGTC_163 TUB2.036 7.546 µM 9.86004871851826 2.09763568787625e-08 yes 59 3.10096458899005e-23 14 15992207 YJR013W GPI14
SGTC_781 4335-2806 94.4 µM 9.83987948460194 2.23608358198546e-08 yes 60 3.79007918073425e-23 4 845254
SGTC_2683 piperine 63.03 µM 9.81407950313365 2.4261439519206e-08 yes 61 4.89638153110176e-23 2 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_676 falcarinol 140 µM 9.80183384597842 2.52174611825909e-08 yes 62 5.52799500977812e-23 4 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2701 st077767 14.721 µM 9.68249190353142 3.66638068305374e-08 yes 63 1.78942333193486e-22 4 5721188
SGTC_605 1315-0399 119 µM 9.65390709394062 4.0076298552906e-08 yes 64 2.3658881996609e-22 2 24020461
SGTC_2296 7971656 126.45 µM 9.51183970771603 6.21399889848224e-08 yes 65 9.36599971197829e-22 4 666570
SGTC_849 0386-0493 241 µM 9.37041169118479 9.55738582718431e-08 yes 66 3.61250785805715e-21 1 726119
SGTC_563 tetrahydrosecaminediol 614 µM 9.36984309153556 9.57382439647184e-08 yes 67 3.63202176186194e-21 1 334274 A psychoactive constituent of the cannabis plant.
SGTC_2396 5342950 42.78 µM 9.33276797028713 1.07067452567198e-07 yes 68 5.15707240433744e-21 2 1886677
SGTC_2322 7413319 38.22 µM 9.32605760724477 1.09251959510277e-07 yes 69 5.49410896116389e-21 22 1840400
SGTC_3174 9107204 49.47 µM 9.30430927870409 1.16631963934295e-07 yes 70 6.74330296510611e-21 2 3938802
SGTC_1508 1080-0625 72.9 µM 9.22503154744296 1.47832326802189e-07 yes 71 1.4173872108938e-20 2 767111
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 9.19565811322622 1.61325540511502e-07 yes 72 1.86353033323814e-20 1 4174840
SGTC_2982 9019404 25.97 µM 9.18998985620211 1.6406280646001e-07 yes 73 1.96439204394481e-20 1 22333232
SGTC_3235 9132602 49.47 µM 8.94298251497383 3.38299442652439e-07 yes 74 1.89402847305467e-19 1 4912240
SGTC_556 4058-0063 51.5 µM 8.77976918132227 5.40192083802476e-07 yes 75 8.19052434975166e-19 1 6615692
SGTC_2921 7974240 10.71 µM 8.75526664427698 5.79104745803349e-07 yes 76 1.01810755481786e-18 4 2979074 YDR527W RBA50
SGTC_3167 9103034 49.47 µM 8.56059927567866 9.99874755672831e-07 yes 77 5.61411682000951e-18 1 5127859
SGTC_413 propylparaben 100 µM 8.45748764896249 1.3290939558216e-06 yes 78 1.36599733823073e-17 1 7175 A pharmaceutical preservative.
SGTC_517 1365-0151 113 µM 8.42296921185396 1.46090976879097e-06 yes 79 1.83530478222215e-17 3 768657
SGTC_1237 0330-0133 46.1 µM 8.41681841773844 1.48567809895929e-06 yes 80 1.93423289915155e-17 3 X1237 YHR072W ERG7
SGTC_79 0052-0007 94.094 µM 8.28503854289935 2.12401811853101e-06 yes 81 5.90354206013658e-17 7 2801472
SGTC_1909 st060837 51.5 µM 8.24618543780959 2.35770820066038e-06 yes 82 8.17654179086039e-17 9 678937
SGTC_1678 st019265 80.2 µM 8.166081572469 2.91960879334072e-06 yes 83 1.59283951247219e-16 2 5367020
SGTC_1975 st070967 30.8 µM 8.16448909518829 2.93198455389761e-06 yes 84 1.61399244277502e-16 6 261391
SGTC_1953 st076800 12.1 µM 8.11649988870043 3.3293823508606e-06 yes 85 2.39910580325073e-16 4 297591
SGTC_2092 5303694 80.6725 µM 8.06787781050833 3.78429588968928e-06 yes 86 3.57652898641737e-16 4 1963699
SGTC_1764 st044502 93.5 µM 8.02710100468176 4.2110703068538e-06 yes 87 4.99014571227493e-16 2 8407
SGTC_2444 5485484 36.41 µM 8.02161499699529 4.27188315382259e-06 yes 88 5.21819062069871e-16 1 6790631
SGTC_603 3794-0023 45.9 µM 7.60284050728635 1.24250854856272e-05 yes 89 1.44850223376875e-14 1 3802260
SGTC_3101 9120531 49.47 µM 7.58183004667763 1.30905472798523e-05 yes 90 1.70357206353521e-14 2 24824904
SGTC_1915 st067105 30.6 µM 7.5680246011357 1.35461117031988e-05 yes 91 1.8947111924604e-14 5 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_860 0443-0016 25.1 µM 7.51204892425642 1.55524218560675e-05 yes 92 2.91045126051485e-14 5 5337942
SGTC_375 3970-0961 9.27 µM 7.41172294486747 1.98738758696549e-05 yes 93 6.2334498507311e-14 4 2898222
SGTC_2498 4'-Methoxychalcone 54.63 µM 7.41066238018365 1.99251325658836e-05 yes 94 6.28350715539077e-14 1 641818 YHR062C RPP1
SGTC_2059 5238311 157 µM 7.39503864191963 2.06949117123422e-05 yes 95 7.06835786018263e-14 3 703021
SGTC_1352 1496-0991 99 µM 7.34352450984925 2.34378127834696e-05 yes 96 1.04020639112061e-13 3 3000039
SGTC_283 0987-0079 11.7 µM 7.30598397097781 2.56501595503997e-05 yes 97 1.37622493360791e-13 2 411556
SGTC_2999 9069765 71.4286 µM 7.30580151952232 2.56613799715239e-05 yes 98 1.37809385638001e-13 1 2097066
SGTC_1123 mangostin 811.285 nM 7.3016099600286 2.5920437613022e-05 yes 99 1.421722769962e-13 6 5281650 An antioxidant.
SGTC_1864 st057645 30.4 µM 7.29915750541244 2.60731578332224e-05 yes 100 1.44787589966116e-13 1 688666
SGTC_2680 butyl paraben 22.24 µM 7.29790983744864 2.61511799756619e-05 yes 101 1.4613618761823e-13 1 7184 An antifungal and steroid mimetic.
SGTC_2852 9023854 51.95 µM 7.28745334836276 2.68138230864784e-05 yes 102 1.57934312932718e-13 3 19798528
SGTC_872 0588-0139 234 µM 7.27054017399034 2.79194241452147e-05 yes 103 1.79026401758259e-13 1 2047100
SGTC_343 4130-2827 29.8 µM 7.2232977313636 3.12409173626938e-05 yes 104 2.53708755727196e-13 2 1118244
SGTC_1629 st005085 44.9 µM 7.2178508746096 3.16470702290274e-05 yes 105 2.64077934881142e-13 4 24207091
SGTC_2688 kanamycin b 96.69 µM 7.20732517966348 3.24461371874586e-05 yes 106 2.85308130277086e-13 98 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 7.17872872852921 3.47145814703142e-05 yes 107 3.51812989698327e-13 6 165506
SGTC_1699 st031318 29.054 µM 7.17317334868635 3.51723300988393e-05 yes 108 3.66394840487285e-13 8 5340658
SGTC_3088 9117578 49.47 µM 7.16724672028136 3.5666961071782e-05 yes 109 3.82605286945545e-13 1 678341
SGTC_180 1486-1293 102.781 µM 7.14202648490112 3.78463399714224e-05 yes 110 4.59824362738295e-13 17 4140536
SGTC_749 1000-0129 128 µM 7.12146271916969 3.97159228520847e-05 yes 111 5.33938107013239e-13 1 708470
SGTC_2499 avocadenofuran 51.48 µM 7.11826371164872 4.00144974935293e-05 yes 112 5.46475533383627e-13 3 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_870 0573-2213 57.6 µM 7.09837897128801 4.19185295768415e-05 yes 113 6.31143293384793e-13 3 3916321
SGTC_1854 st056233 32.9 µM 7.07218959199348 4.45571296526397e-05 yes 114 7.62539274219627e-13 1 5393174
SGTC_3211 9128781 49.47 µM 6.94431986208644 5.98517903132115e-05 yes 115 1.90143990985342e-12 13 17194361
SGTC_3034 9090421 49.47 µM 6.88967037248786 6.77957701954905e-05 yes 116 2.79609069343087e-12 2 17173761
SGTC_1710 st031758 61.5 µM 6.86028239156733 7.24683622201986e-05 yes 117 3.43622786926385e-12 3 5394341
SGTC_3065 9113888 49.47 µM 6.83499702322037 7.6729734464577e-05 yes 118 4.10033658214512e-12 2 16648368
SGTC_3143 9086658 49.47 µM 6.78719107962435 8.54386054939767e-05 yes 119 5.71688672177273e-12 4 25236626
SGTC_1892 st058411 7.36 µM 6.75510855069832 9.17956063989393e-05 yes 120 7.13641779085244e-12 2 3934738
SGTC_2424 5537928 59.2 µM 6.74216016480546 9.4485090968178e-05 yes 121 7.80244600352956e-12 4 5382802
SGTC_3168 9103419 49.47 µM 6.71687254474199 9.99524423867123e-05 yes 122 9.28331153285857e-12 2 16649256
SGTC_1369 1866-0067 208 µM 6.69379261772774 0.000105200642093611 yes 123 1.08729769819272e-11 7 3531355
SGTC_2607 solasodine 47.35 µM 6.64720321961219 0.000116592818338348 yes 124 1.49357238234355e-11 23 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2094 5332512 191.667 µM 6.61464748432248 0.000125229870024583 yes 125 1.86219090382721e-11 5 755774
SGTC_2557 derrustone 83.84 µM 6.60639972581561 0.000127511376010473 yes 126 1.96889385462981e-11 2 629853 An antioxidant.
SGTC_1865 st057639 52.2 µM 6.60512460345849 0.000127867561718855 yes 127 1.98591566748517e-11 2 688818
SGTC_3131 9127911 49.47 µM 6.59900717418928 0.000129589383822047 yes 128 2.06960142891105e-11 3 45595681
SGTC_2594 a-mangostin 100 µM 6.5191666425045 0.000154149211490799 yes 129 3.53495376745107e-11 7 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_474 dl-dihydrosphingosine 5 µM 6.48466313589763 0.000166057572463187 yes 130 4.44651271990479e-11 9 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2651 TUB2.036 5 µM 6.4846225342208 0.000166072079352444 yes 131 4.44771024287456e-11 59 15992207 YFL037W TUB2
SGTC_3025 9087895 49.47 µM 6.45081148954412 0.000178573106247083 yes 132 5.56264077010373e-11 8 17173641
SGTC_1013 4112-3890 241 µM 6.42874917529391 0.000187198973621684 yes 133 6.43291091593855e-11 6 705171
SGTC_1883 5-benzylidenerhodanine 20 µM 6.36783859673171 0.000213078614011351 yes 134 9.58552484013613e-11 16 1273210
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 6.33165103553586 0.000229997884094921 yes 135 1.212757880589e-10 4 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_110 0850-0284 111.64 µM 6.32262878354546 0.000234407200705287 yes 136 1.28575274090728e-10 4 3906265
SGTC_1130 3454-2858 15.9 µM 6.28751299668346 0.000252330588149245 yes 137 1.61296006443859e-10 36 715628 YIL048W NEO1
SGTC_1194 1488-0194 225 µM 6.28470790679262 0.000253816096511569 yes 138 1.6423534098887e-10 3 1391452
SGTC_702 1488-0190 94 µM 6.27874489478673 0.000257001091570099 yes 139 1.70658542816214e-10 1 949357
SGTC_2939 9044578 71.43 µM 6.26210908657064 0.000266084731428692 yes 140 1.89902542105726e-10 12 2653634
SGTC_425 3825-7017 13.1 µM 6.24140206631633 0.000277809337085981 yes 141 2.16832962022169e-10 6 3397440
SGTC_1478 0453-0656 35.7 µM 6.22261339738707 0.000288862421593022 yes 142 2.44470573326486e-10 4 5258496
SGTC_394 menadione 8.33 µM 6.21380655722197 0.000294183080543518 yes 143 2.58580944560166e-10 12 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1819 st053448 58.6 µM 6.20584865804007 0.000299069177816366 yes 144 2.72012569548318e-10 1 2857616
SGTC_505 gw-5074 63.9 µM 6.1981638547082 0.000303859193882188 yes 145 2.85628268669084e-10 24 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1100 amiodarone 5.07 µM 6.19025362099615 0.000308864219310372 yes 146 3.00337438687983e-10 2 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1474 0330-0125 5.35 µM 6.16737377772298 0.000323776075104792 yes 147 3.47167485426807e-10 5 X1474
SGTC_2233 sulbentine 40.3845 µM 6.1600866254522 0.000328664291466157 yes 148 3.63525811141036e-10 22 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2430 5571206 200 µM 6.15235478168125 0.000333925783301766 yes 149 3.81704316891826e-10 22 1731771
SGTC_2924 9010168 62.78 µM 6.12623713472455 0.000352283403930687 yes 150 4.49908347927844e-10 8 2993929
SGTC_2658 polymyxin b sulfate 77.05 µM 6.11657564555672 0.000359308737282584 yes 151 4.7803756663528e-10 22 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 6.10234016551213 0.000369897516747961 yes 152 5.22633090695187e-10 8 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_683 panaxydol 45 µM 6.10202134775011 0.000370137947730183 yes 153 5.23676910470487e-10 14 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3292 9120825 59.784 µM 6.08881105087709 0.000380228821885461 yes 154 5.68761362658189e-10 3 24824900
SGTC_3155 9099265 49.47 µM 6.03564985522471 0.000423474364451962 yes 155 7.91621115148252e-10 5 25236499
SGTC_1614 st002383 48.6 µM 6.02497413571232 0.000432691199382947 yes 156 8.45683346402202e-10 6 1947235
SGTC_534 k292-0788 63.4 µM 5.99134068352081 0.000462958677556243 yes 157 1.04059071291106e-09 4 4146317
SGTC_126 0417-1624 672.48 µM 5.98509990856018 0.000468786251318156 yes 158 1.08128538113711e-09 3 41912 YDL195W SEC31
SGTC_3100 9120536 49.47 µM 5.94288562005437 0.000510025105769704 yes 159 1.40023925411176e-09 2 16421196
SGTC_1970 st070122 35.8 µM 5.94275948124997 0.000510153211689297 yes 160 1.40131755336686e-09 7 102928
SGTC_2055 5235184 200 µM 5.93233705785165 0.000520841654565194 yes 161 1.49326362180081e-09 8 2836034
SGTC_2581 avocatin a 64 µM 5.91521443430392 0.000538852152456039 yes 162 1.65721743789576e-09 19 6710728 A skin care supplement.
SGTC_279 1273-0055 2.93 µM 5.88756959913182 0.000569150343957411 yes 163 1.9595807219856e-09 16 2847562
SGTC_2462 5162487 171.77 µM 5.8209849324033 0.000648704379517886 yes 164 2.92509220453747e-09 5 2259986
SGTC_109 0132-0036 33.701 µM 5.81412448749023 0.000657459394814957 yes 165 3.04760219803352e-09 11 67274 A color developer.
SGTC_1360 1598-0022 39.8 µM 5.79455977840333 0.000683029462071894 yes 166 3.4250310989855e-09 9 761525
SGTC_942 3253-1115 227 µM 5.77024294762931 0.000716088302284796 yes 167 3.9578663520993e-09 4 46497897
SGTC_410 α-linolenic acid 100 µM 5.76858799108531 0.000718390978932508 yes 168 3.99692359396863e-09 14 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2413 inermin 26.06 µM 5.75099294444403 0.000743297974057264 yes 169 4.4360409085546e-09 21 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1263 0774-1208 64.8 µM 5.74226320077014 0.000755948635500863 yes 170 4.67097332738402e-09 8 906585
SGTC_650 1328-0195 38 µM 5.73286406105731 0.000769790870123003 yes 171 4.93743882015573e-09 4 2780821
SGTC_2696 st077691 74.316 µM 5.72122851697186 0.000787249967497748 yes 172 5.28782700424675e-09 7 757133
SGTC_2335 9018011 154.17 µM 5.67471959874723 0.000860739579421978 yes 173 6.945800495255e-09 6 6458208
SGTC_1245 0418-0076 17.2 µM 5.66543154632688 0.000876151253335188 yes 174 7.33274824005504e-09 7 6790114
SGTC_2197 6588183 93.1375 µM 5.66123776067792 0.00088319280571027 yes 175 7.51425160595202e-09 13 884136
SGTC_2855 9016525 58.44 µM 5.61870886404324 0.000957597760219876 yes 176 9.61948617021105e-09 4 43811474
SGTC_333 3486-0131 40.1 µM 5.60788230425223 0.000977436865234326 yes 177 1.02408613167897e-08 1 6744690
SGTC_2600 tangeritin 87.95 µM 5.58932401305498 0.00101232379438998 no 178 1.13977629474648e-08 8 68077 A bioactive flavone.
SGTC_2135 5326629 150.42 µM 5.55781499944189 0.00107418308884397 no 179 1.36586347260288e-08 6 5020077
SGTC_777 1315-0167 517 µM 5.53164854686999 0.00112816731230779 no 180 1.58617520866108e-08 11 4221767
SGTC_207 4185-0010 4.486 µM 5.5092284171488 0.00117638778107318 no 181 1.80204990776358e-08 48 3761753
SGTC_2120 5538279 151.968 µM 5.49996545225879 0.00119685553546155 no 182 1.89932835282285e-08 3 2058197
SGTC_41 0478-0632 82.643 µM 5.49691269343694 0.00120367210563326 no 183 1.93248964032951e-08 8 3750424
SGTC_2523 spermine 47.74 µM 5.49235612027098 0.00121391269998954 no 184 1.98303315659784e-08 12 1103 A DNA binding polyamine.
SGTC_2940 9060638 45.86 µM 5.46586650391147 0.00127504209714649 no 185 2.30325466286332e-08 3 4027022
SGTC_3185 9108267 49.47 µM 5.42901524790492 0.00136476989068524 no 186 2.83329215812076e-08 2 4910486
SGTC_538 2922-0838 53.3 µM 5.41674017873555 0.00139591553113518 no 187 3.03477203586335e-08 9 777039
SGTC_2446 5162541 200 µM 5.37528478532319 0.00150595963088692 no 188 3.82308660711437e-08 2 1549321
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 5.35417852288294 0.00156497561382168 no 189 4.29729872283808e-08 6 521171
SGTC_2998 9066762 71.4286 µM 5.34798774553024 0.00158268149332907 no 190 4.44687427720213e-08 5 4945196
SGTC_3269 9137823 49.47 µM 5.34752916528772 0.00158400028785263 no 191 4.4581523706614e-08 4 17682936
SGTC_2310 7668677 200 µM 5.31370229383826 0.00168408754168286 no 192 5.37100309089581e-08 8 2197143
SGTC_3136 9095672 49.47 µM 5.27907941824258 0.00179246242385632 no 193 6.49172631640269e-08 6 17217380
SGTC_1604 st002052 72.4 µM 5.2366811533225 0.00193379908744904 no 194 8.17448848418913e-08 9 6254834 YHR062C RPP1
SGTC_290 2043-6722 48.1 µM 5.21099951092468 0.00202425937903181 no 195 9.39129737173065e-08 1 773758 YLR208W SEC13
SGTC_2297 7971671 152.32 µM 5.20603483499701 0.00204218363935221 no 196 9.64592227590035e-08 8 909016
SGTC_2442 5158906 48.48 µM 5.20438833953566 0.00204815980989536 no 197 9.73183057092841e-08 5 1893835
SGTC_537 1334-0398 209 µM 5.19087197947905 0.00209782234644513 no 198 1.04655754592275e-07 7 5846986
SGTC_179 1273-0063 6.77 µM 5.17451074254817 0.0021593978116164 no 199 1.14254481798985e-07 8 3108139
SGTC_3337 9144342 33.5465 µM 5.17318451487943 0.00216446016480501 no 200 1.15068773064936e-07 17 17682949
SGTC_1268 0828-0275 2.46 µM 5.15962945107469 0.00221682170033694 no 201 1.23719543113369e-07 5 745337
SGTC_1859 st055998 20 µM 5.15840183024888 0.00222162008430237 no 202 1.24533319590534e-07 8 676301
SGTC_2934 9036370 36.88 µM 5.15413096315238 0.00223838698185905 no 203 1.27404912131e-07 15 6462800
SGTC_3072 9116419 49.47 µM 5.12345860528054 0.00236221087358514 no 204 1.49990763652529e-07 2 17170162
SGTC_2472 5377652 49.4 µM 5.10910287647555 0.00242226773823498 no 205 1.6184603933563e-07 28 1610903
SGTC_2496 diffractaic acid 79.83 µM 5.10080489304286 0.00245760893445029 no 206 1.69106035970812e-07 8 94870 An apoptosis inducer which activates caspases.
SGTC_1973 st070275 50.2 µM 5.07707750095094 0.00256125241443794 no 207 1.91642280703979e-07 4 17118334
SGTC_1279 0874-0590 65.2 µM 5.07059342937401 0.0025902545671342 no 208 1.98288584297485e-07 15 3523074
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 5.06706680311576 0.00260615285610148 no 209 2.01996267200315e-07 46 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_543 3844-1095 191 µM 5.05039708162339 0.00268250092169856 no 210 2.20446302456111e-07 26 4230703
SGTC_2175 5807670 165.306 µM 5.01886058898206 0.00283248607035648 no 211 2.59894262553336e-07 10 241186
SGTC_3046 9092212 49.47 µM 4.98281442443016 0.00301315191105992 no 212 3.13330224377952e-07 3 25236637
SGTC_2213 7173844 200 µM 4.98007705895486 0.0030272869969442 no 213 3.17794801828321e-07 4 892728
SGTC_1061 3448-9325 110 µM 4.97415611223094 0.00305806584899138 no 214 3.27662418486631e-07 10 723482
SGTC_667 1498-1044 59 µM 4.94242761175078 0.00322785246286187 no 215 3.85778784176281e-07 5 6739982
SGTC_1618 st003135 44.5 µM 4.92179388879596 0.00334277183874971 no 216 4.28772515332351e-07 7 1270615
SGTC_980 1473-0395 201 µM 4.91990842847366 0.00335345414130581 no 217 4.32923557363565e-07 3 768876
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 4.90842895385102 0.00341915722428753 no 218 4.59044379762731e-07 11 688664
SGTC_559 1550-0661 158 µM 4.87798544456106 0.00359903833276007 no 219 5.35874157661143e-07 2 5830875
SGTC_1520 flindersine 88 µM 4.83365731000772 0.00387615828428243 no 220 6.70236304038378e-07 15 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3338 9144300 39.5675 µM 4.83233396783635 0.00388471747531204 no 221 6.74708192159366e-07 10 4901274
SGTC_903 1134-0042 114 µM 4.80079511802306 0.00409378174109662 no 222 7.90184454885635e-07 12 701009
SGTC_3284 9108171 64.8615 µM 4.7984694930188 0.00410958929794773 no 223 7.99413270107781e-07 10 8687505
SGTC_1287 0971-0001 34.6 µM 4.76572256323028 0.00433804672833211 no 224 9.40890233327736e-07 31 4665869
SGTC_2869 9037858 32.47 µM 4.76413294367062 0.00434942006770944 no 225 9.48337155226871e-07 4 27187042
SGTC_178 4092-0806 87.505 µM 4.75774566489575 0.00439538861561275 no 226 9.78834683693502e-07 60 2169044
SGTC_167 3672-0051 66.205 µM 4.74991511545888 0.00445233621412625 no 227 1.01751025606689e-06 24 3237971
SGTC_886 0866-0150 153 µM 4.74806196560903 0.00446590929269624 no 228 1.02687559795767e-06 7 271463
SGTC_662 k832-1615 104 µM 4.73590784547828 0.00455584975741847 no 229 1.09038335566495e-06 7 5878478
SGTC_2873 9040596 71.43 µM 4.72808197863798 0.00461461356106709 no 230 1.13325339495672e-06 27 6463863
SGTC_2312 7706453 155.7 µM 4.70715186280135 0.00477511346512832 no 231 1.25600886567774e-06 17 976098
SGTC_880 0833-0487 87.2 µM 4.70344033324066 0.00480408884641467 no 232 1.27906939677382e-06 7 76075
SGTC_1724 st037281 8.293 µM 4.69142828218452 0.00489894283123684 no 233 1.35652187257887e-06 25 574124 YDL195W SEC31
SGTC_3099 9120367 49.47 µM 4.68831387871927 0.00492380680931876 no 234 1.37732644445064e-06 7 24824940
SGTC_987 1497-1013 404 µM 4.6856169619669 0.00494542854144664 no 235 1.39558922484139e-06 7 1676435
SGTC_812 4251-0442 148 µM 4.67206739751376 0.00505534336479836 no 236 1.49091537412884e-06 6 5723007
SGTC_3037 9091026 49.47 µM 4.66522105304105 0.00511170427613079 no 237 1.54142722830343e-06 86 25236398 YIL048W NEO1
SGTC_2588 indole-3-carbinol 100 µM 4.64391519923388 0.00529069541565177 no 238 1.70933964043848e-06 23 3712 Induces cell cycle arrest.
SGTC_2122 5258151 111.688 µM 4.6421523964385 0.00530575153885324 no 239 1.72399195483625e-06 16 2173356
SGTC_22 0964-0034 14.468 µM 4.64094560602912 0.00531608071322939 no 240 1.73409209182587e-06 32 138402
SGTC_3234 9132280 49.47 µM 4.62443845305131 0.00545917497058972 no 241 1.87807295648776e-06 9 17612295
SGTC_550 4123-0385 25.7 µM 4.61933831067754 0.00550407311777451 no 242 1.92482866902508e-06 14 5731123
SGTC_275 trichlorophene 5.69 µM 4.61326477699037 0.00555796810269748 no 243 1.98196406740082e-06 192 62616
SGTC_3274 9138298 49.47 µM 4.60557385593295 0.00562688772616374 no 244 2.05664981333025e-06 9 17015756
SGTC_1527 coumarin 137 µM 4.59966261419979 0.00568037406907759 no 245 2.11587873824798e-06 10 323 A hepatotoxic, DNA x-linker.
SGTC_2218 6965428 192.983 µM 4.56097431935425 0.00604171442612238 no 246 2.54584043013009e-06 5 675684
SGTC_1575 cyproterone acetate 48 µM 4.55098941058082 0.00613821787816411 no 247 2.66971178284369e-06 10 9880 An androgen receptor antagonist and liver toxin.
SGTC_2458 5808907 16.39 µM 4.53941402990972 0.00625180033685438 no 248 2.82053869810741e-06 3 2731747
SGTC_1955 wogonin 32.4 µM 4.4904671732619 0.00675292141251527 no 249 3.5533563817346e-06 11 5281703 A flavanone.
SGTC_960 1222-0186 7.7 µM 4.48447500949438 0.00681664553979003 no 250 3.65468357666875e-06 18 3126296
SGTC_638 3970-0837 4.09 µM 4.47719501074227 0.00689477952488335 no 251 3.78150800173662e-06 23 4118451 YLR208W SEC13
SGTC_1011 4112-3381 17.4 µM 4.47616098237629 0.0069059413372246 no 252 3.79985951686802e-06 26 2877139
SGTC_14 0354-0009 295 µM 4.47039095557285 0.00696851926912879 no 253 3.90383718788837e-06 18 1713507
SGTC_1982 st072467 71.9 µM 4.45675240032944 0.00711842804186205 no 254 4.16053083727412e-06 26 3163533
SGTC_1004 4084-0029 199 µM 4.4444009351939 0.00725663739542533 no 255 4.40685537523391e-06 8 716894 YLR208W SEC13
SGTC_1561 5-methoxyflavone 52.9 µM 4.4440046592378 0.0072611105170283 no 256 4.41498454212165e-06 4 94525
SGTC_992 3909-8734 162 µM 4.42444187457006 0.00748497765284042 no 257 4.83459660272489e-06 9 4288319
SGTC_2283 7944793 200 µM 4.41552132008207 0.00758906320598081 no 258 5.03834236038469e-06 26 2970533
SGTC_1991 st073000 8.92 µM 4.38700277427237 0.00793041929013105 no 259 5.74616622201061e-06 63 4301969 YIL048W NEO1
SGTC_792 4534-1957 155 µM 4.38415433358251 0.00796524465657395 no 260 5.8218603267426e-06 22 1717904
SGTC_923 1900-2434 73.3 µM 4.37587736258466 0.00806720409844567 no 261 6.04725018298077e-06 23 5910570
SGTC_2151 5563267 85.4165 µM 4.3726939737714 0.00810672290849303 no 262 6.13613474060939e-06 14 5310824
SGTC_1393 3470-5649 58.2 µM 4.36444353790867 0.00820993727240642 no 263 6.37233803691305e-06 8 4108395
SGTC_852 0418-0143 439 µM 4.32257383792241 0.00875172509344789 no 264 7.7109722661417e-06 54 5369229
SGTC_1213 1315-0166 115 µM 4.32117969939277 0.00877029203424177 no 265 7.75986069489941e-06 19 768401
SGTC_991 3996-0057 64.7 µM 4.30671806584357 0.00896493618933995 no 266 8.28472889046903e-06 16 715343
SGTC_723 4182-0001 115 µM 4.29787784829821 0.0090857745503418 no 267 8.62205720037967e-06 23 744821 YLR208W SEC13
SGTC_2253 7938677 135.83 µM 4.28509640962729 0.00926300726784418 no 268 9.13299798449298e-06 8 2301972
SGTC_468 gf-109203x 121 µM 4.28484226815023 0.00926656176194343 no 269 9.14344406443759e-06 3 2396 A protein kinase C inhibitor.
SGTC_2689 tacrolimus 100 µM 4.27588859786723 0.00939255445234716 no 270 9.5188204807457e-06 37 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_738 1315-0003 72.4 µM 4.2585232171589 0.00964119049020767 no 271 1.02890924986443e-05 16 6251474
SGTC_2717 st081029 62.2815 µM 4.2505140633632 0.00975779021643963 no 272 1.06640221503566e-05 12 5292846
SGTC_697 0508-1955 564 µM 4.24350144075079 0.00986089173529844 no 273 1.10029479714257e-05 25 6243113
SGTC_2166 5933061 31.504 µM 4.22243503481535 0.0101763584009602 no 274 1.20838534994696e-05 29 2877375
SGTC_43 0570-0105 72.5 µM 4.16721786650795 0.011045345454988 no 275 1.54169887824122e-05 86 1114046 YDL195W SEC31
SGTC_127 0180-0333 59.125 µM 4.15103314251575 0.0113119893113489 no 276 1.6548891430386e-05 36 771601
SGTC_1313 1220-0047 237 µM 4.13787682358539 0.0115328448724177 no 277 1.75267228703652e-05 33 3528706
SGTC_2366 9070441 60.58 µM 4.13436132266274 0.0115924900080324 no 278 1.77971551868979e-05 25 6837235
SGTC_1164 k060-0068 93.7 µM 4.13087361157625 0.0116519281466566 no 279 1.80693620439423e-05 20 5963676
SGTC_1750 st081859 2.357 µM 4.12941236703442 0.0116769094500413 no 280 1.81845795150728e-05 173 5291695
SGTC_1738 st035555 74 µM 4.11721103895515 0.0118873232844111 no 281 1.91742443998353e-05 27 5331140
SGTC_3293 9120939 62.045 µM 4.11147939177063 0.0119872967189176 no 282 1.96565985075462e-05 18 934087
SGTC_1069 diphenylcyclopropenone 8.49 µM 4.1052178721845 0.0120973449720258 no 283 2.01966997586322e-05 31 65057 A dermal irritant. YDR527W RBA50
SGTC_1494 4358-1428 177 µM 4.10245483395114 0.0121461841186469 no 284 2.04394836085548e-05 19 1564571
SGTC_1114 scopoletin 1.73284 µM 4.07219100814927 0.0126924104341458 no 285 2.32864808351706e-05 19 5280460 A coumarin with genotoxic properties.
SGTC_323 4013-0906 34.3 µM 4.07001995890211 0.0127323999217453 no 286 2.35045551130796e-05 12 2910086
SGTC_1751 st044839 27.194 µM 4.06372770210813 0.0128489161161024 no 287 2.41475817056071e-05 11 5291326
SGTC_35 0133-0054 64.071 µM 3.99655831218859 0.0141512931477223 no 288 3.21350278661194e-05 31 99677
SGTC_2067 5224629 34.075 µM 3.99596187829534 0.0141633492972693 no 289 3.22160512663151e-05 26 2835000
SGTC_3342 9147791 14.508 µM 3.99512820864609 0.0141802156936788 no 290 3.23296263674139e-05 14 1838168
SGTC_2425 5628681 7.85 µM 3.98962845239465 0.0142919182905085 no 291 3.30884370064211e-05 23 5714958
SGTC_593 1203-0218 61.7 µM 3.98285968815673 0.0144304346456366 no 292 3.40454797850884e-05 7 3666956
SGTC_3193 9111931 49.47 µM 3.97183786160844 0.0146584592621836 no 293 3.56601288808588e-05 23 17087244
SGTC_2452 5863136 48.41 µM 3.96280951113545 0.0148475450981581 no 294 3.70364414450926e-05 23 2184096
SGTC_386 1509-0011 3.07 µM 3.9610977546901 0.0148836309299929 no 295 3.73029897619726e-05 146 3107280
SGTC_1742 st038235 28.8875 µM 3.94152568913466 0.0153016223835012 no 296 4.04824807848503e-05 115 564103 YBR002C RER2
SGTC_1674 st016616 23.6 µM 3.93792311169262 0.0153796496928204 no 297 4.10949601469666e-05 27 625830
SGTC_3102 9121669 49.47 µM 3.93358355586089 0.0154740924276887 no 298 4.18443641607171e-05 10 41905072
SGTC_2152 5568786 200 µM 3.93096659848289 0.0155312861549789 no 299 4.23025133387489e-05 11 5399883
SGTC_84 0443-0269 128.823 µM 3.92866771174526 0.0155816780362045 no 300 4.27088852376952e-05 22 6150058
SGTC_2610 ononetin 44.17 µM 3.92289706075323 0.0157087899556795 no 301 4.37452694826398e-05 45 259632
SGTC_2872 9044037 25.97 µM 3.90441269199421 0.016121956244926 no 302 4.72272413028939e-05 3 6465195
SGTC_2596 sinensetin 100 µM 3.88170780156855 0.0166421733423851 no 303 5.1862732085419e-05 35 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2086 5274770 176.623 µM 3.87675127138994 0.0167576287160529 no 304 5.29302392343261e-05 25 689278
SGTC_146 3448-8650 53.125 µM 3.86360185764364 0.0170672508803671 no 305 5.58636367240291e-05 142 2891488 YIL048W NEO1
SGTC_1778 st046819 58.9 µM 3.86058265121458 0.0171390287542037 no 306 5.65584846738218e-05 27 671715
SGTC_679 0422-0091 41.4 µM 3.84672629101036 0.0174717641394111 no 307 5.98532847891392e-05 32 627384 YHR062C RPP1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.82153964290393 0.0180907089435991 no 308 6.63105446246439e-05 48 688788
SGTC_1917 st066507 28.5 µM 3.80924937890802 0.018399457852058 no 309 6.96946576354086e-05 41 3156428
SGTC_1267 0828-0272 9.49 µM 3.80046565450683 0.0186228577625182 no 310 7.22122177350671e-05 22 745334
SGTC_2604 4'-hydroxychalcone 11.32 µM 3.80004312155461 0.0186336621671995 no 311 7.2335455751209e-05 43 5282362
SGTC_236 1509-0011 5.31 µM 3.79866079698106 0.0186690462731298 no 312 7.27400165352793e-05 393 3107280
SGTC_2679 rapamycin 1 nM 3.79347073952687 0.0188024098892996 no 313 7.4278071957294e-05 156 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2384 9036245 200 µM 3.76776391451122 0.0194749839364778 no 314 8.23581826036918e-05 34 6462766
SGTC_1525 8-methoxypsoralen 92.5 µM 3.76726545208881 0.019488224732624 no 315 8.25227403653334e-05 35 4114 Related to psoralen; DNA damaging agent.
SGTC_3098 9119039 49.47 µM 3.75362284987713 0.019853596856161 no 316 8.71485247668123e-05 41 17161528
SGTC_1941 st076221 61.8 µM 3.74012050594655 0.0202209202125565 no 317 9.19660261191604e-05 88 2828568
SGTC_736 0958-0254 92.6 µM 3.72224691811715 0.0207160095488713 no 318 9.87288928666827e-05 41 6812352
SGTC_530 4358-1714 28 µM 3.72043511943868 0.0207667636867621 no 319 9.94399155906987e-05 51 1564641
SGTC_85 0868-0259 160.055 µM 3.69856060523673 0.0213878918432837 no 320 0.000108412790812207 15 83173
SGTC_850 0388-0143 75.9 µM 3.6914356856076 0.0215935657479539 no 321 0.000111495893042397 17 67273
SGTC_2801 7907800 81.82 µM 3.67976212247929 0.0219341564591846 no 322 0.000116725809356964 37 6620925
SGTC_1801 st050089 28.441 µM 3.67773493148402 0.0219937621289695 no 323 0.000117657154467917 135 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 3.67271774426667 0.0221418712034781 no 324 0.000119992255147922 20 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1868 st057644 42.7 µM 3.6684130460127 0.0222696174504296 no 325 0.000122030335293518 46 688665
SGTC_1373 2887-0003 58.5 µM 3.64974174991147 0.0228309275014498 no 326 0.000131252044194567 26 776948
SGTC_2752 diclazuril 33.15 µM 3.64303565710494 0.0230354193874716 no 327 0.000134720748014077 142 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3347 9188721 44.724 µM 3.62542728482603 0.0235797138937084 no 328 0.000144242032288102 31 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1125 tnp00248 1.32998 µM 3.62534237897239 0.0235823644102944 no 329 0.000144289433708677 44 24207736
SGTC_188 3229-0966 278.469 µM 3.61828293776258 0.023803618139845 no 330 0.000148282040468924 34 5722370
SGTC_1935 st074532 41.6 µM 3.60841430406304 0.024115839112646 no 331 0.000154037120535115 42 2829742
SGTC_17 0960-0276 49.807 µM 3.60328719467679 0.0242794024887248 no 332 0.000157109007767048 52 6821114
SGTC_464 bw-b 70c 158 µM 3.58100111352069 0.0250012303211606 no 333 0.00017114009764725 35 5353454
SGTC_2906 7926292 26.41 µM 3.5802038185568 0.0250273838680795 no 334 0.00017166315166963 36 2966319
SGTC_3299 9121982 43.1275 µM 3.57586151484237 0.0251702267424178 no 335 0.000174538207672494 42 17594604 YPL160W CDC60
SGTC_542 3381-0244 89.3 µM 3.57503625847784 0.0251974512010065 no 336 0.000175089681175686 56 1112843
SGTC_2695 st077686 51.995 µM 3.55789451557209 0.0257685449705395 no 337 0.000186919686677496 51 2876092
SGTC_2681 menadione 3.18 µM 3.5442893053302 0.0262294911648548 no 338 0.0001968365059834 38 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2372 9071633 200 µM 3.53598193082187 0.026514321130297 no 339 0.000203131240076658 18 21321366
SGTC_5 0352-0601 109.883 µM 3.53378521637754 0.0265900691311049 no 340 0.000204826915137159 24 762456
SGTC_2168 5727979 200 µM 3.5308454966214 0.0266917205095559 no 341 0.000207116817648981 29 695210
SGTC_198 3454-2873 16.191 µM 3.53073523043388 0.0266955396660972 no 342 0.000207203173260229 27 710957
SGTC_614 0462-0418 107 µM 3.52773119435015 0.0267997625510113 no 343 0.000209568779353048 44 5188303
SGTC_2970 9090938 41.86 µM 3.51624798004323 0.0272013012276261 no 344 0.000218845985333087 63 17217104
SGTC_13 0199-0087 65 µM 3.51596406401362 0.0272112922846234 no 345 0.000219080142964931 14 4589825
SGTC_3298 9116858 71.43 µM 3.51392852657485 0.0272830129127095 no 346 0.000220765799054027 19 2506942
SGTC_1837 st055472 66.5 µM 3.51177790559455 0.027358959654512 no 347 0.000222559904790415 30 676091
SGTC_1996 st072960 66.8 µM 3.5107358244433 0.0273958229355153 no 348 0.00022343412296473 32 1719405
SGTC_2944 9067346 25.62 µM 3.49720903975044 0.02787809835072 no 349 0.00023507663341305 42 6473075
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 3.49524087235171 0.0279488560475071 no 350 0.000236817054244238 59 6728940
SGTC_59 0330-0160 1.33 µM 3.46455323617778 0.029071594079209 no 351 0.000265556503162578 153 4293482
SGTC_2913 7966556 36.57 µM 3.4562474866468 0.0293818322746887 no 352 0.000273876076309585 25 2976516
SGTC_907 3448-6986 75.5 µM 3.4484524782533 0.02967548897342 no 353 0.000281904335913386 44 590582
SGTC_1496 4469-0713 57.4 µM 3.43968234232403 0.0300087884020677 no 354 0.000291198658107852 32 746691
SGTC_1111 tnp00062 510.699 nM 3.43732798142812 0.0300987899674399 no 355 0.00029374187476494 17 676306
SGTC_2540 epiandrosterone 100 µM 3.4036855889585 0.0314094850115024 no 356 0.000332416158499094 86 441302 A steroid.
SGTC_2316 5844804 197.44 µM 3.39551538415089 0.0317348172374849 no 357 0.000342497621102412 63 776813
SGTC_2953 9074162 66.49 µM 3.38243382369071 0.0322615107114056 no 358 0.00035923292867335 45 16451992
SGTC_2355 9061122 103.12 µM 3.37682787004514 0.0324894170978273 no 359 0.000366634610483905 25 5302957
SGTC_1270 0831-1170 17.3 µM 3.36470296088978 0.0329868918284408 no 360 0.000383130519624448 25 6764716
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.35733966503042 0.0332920534730714 no 361 0.000393481854787217 48 6312947
SGTC_1562 morin hydrate 59.1 µM 3.35722021056319 0.033297023199249 no 362 0.00039365190397463 34 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2435 5706476 10.6 µM 3.33816706729577 0.0340975570523264 no 363 0.000421665133118635 43 5725375
SGTC_1838 st055369 84.5 µM 3.33717727413719 0.0341395727533827 no 364 0.000423169737676905 36 676036
SGTC_222 nsc-310342 10.666 µM 3.32318253429057 0.0347382037320274 no 365 0.000444983291698248 8 432556
SGTC_1379 2144-0755 36.5 µM 3.31269624351253 0.0351923860520914 no 366 0.000462006378541606 40 5392327
SGTC_3323 9138564 53.9225 µM 3.30838774566466 0.0353804024136923 no 367 0.000469173969552747 43 43912313 YNL103W MET4
SGTC_3146 9095609 49.47 µM 3.3067193157164 0.035453431098569 no 368 0.000471977125069629 40 17173999
SGTC_2421 5690543 90.72 µM 3.30090511138617 0.0357088905212555 no 369 0.000481867351957113 40 3397993
SGTC_1304 1165-0502 251 µM 3.29579655021737 0.0359345892213619 no 370 0.000490715305370802 94 767425
SGTC_1733 st037357 54.9 µM 3.28994796702258 0.0361944158226502 no 371 0.000501029554621862 72 1272339 YGL099W LSG1
SGTC_3128 9127691 49.47 µM 3.28694799674475 0.0363282868643619 no 372 0.000506397674558766 37 41316314
SGTC_3062 9077494 49.47 µM 3.28252630810275 0.0365263394985998 no 373 0.000514406926044466 54 16459633
SGTC_308 4092-1169 104 µM 3.27542554412813 0.0368462388960026 no 374 0.000527514602544388 82 2268590 YDL196W YDL196W
SGTC_2524 avocatin b 10.57 µM 3.26353981458487 0.0373868318777898 no 375 0.00055014861536565 43 6710748
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.26324757448801 0.0374002048632762 no 376 0.000550716275730835 33 688801
SGTC_1258 0671-0043 57.1 µM 3.25126676205803 0.0379518221978217 no 377 0.000574460005705703 58 4298767
SGTC_2794 7785382 27.27 µM 3.23898208521447 0.0385243044742331 no 378 0.000599785539133329 68 2205081
SGTC_2770 toltrazuril 17.5 µM 3.23201755701179 0.0388519742971621 no 379 0.000614597517493513 58 68591 Kills coccidiodes.
SGTC_2551 apiole 73.87 µM 3.2311282528977 0.0388939775693358 no 380 0.000616512999555704 22 10659 A possible DNA adduct former.
SGTC_961 1252-1571 372 µM 3.23082681307508 0.0389082234492207 no 381 0.000617163524260334 53 6813498
SGTC_2127 5253358 187.912 µM 3.22628304089829 0.0391234748411559 no 382 0.000627046354547533 50 20612
SGTC_286 k060-0067 22.9 µM 3.22133243265192 0.0393591016181234 no 383 0.00063798026076125 42 5985051
SGTC_2585 alliin 100 µM 3.21289191377539 0.0397634940709619 no 384 0.000657028657117475 54 87310 A garlic compound which reacts with lipids.
SGTC_904 1141-0088 396 µM 3.18328588015854 0.0412087223499425 no 385 0.000728068834994443 45 1378119
SGTC_387 norethindrone acetate 66.7 µM 3.18259690633813 0.0412428552670079 no 386 0.000729803313794371 46 541197
SGTC_1885 st057546 99.9 µM 3.18090322502408 0.041326860505476 no 387 0.000734083324659834 43 702008
SGTC_1907 st060210 83.7 µM 3.18011349221137 0.041366078004575 no 388 0.000736086912854775 53 688793
SGTC_77 0828-0286 12.516 µM 3.17908269458396 0.0414173119623699 no 389 0.000738709675034297 75 745345
SGTC_1128 3448-9350 235 µM 3.17891022036893 0.0414258895056243 no 390 0.000739149358585326 55 619386
SGTC_2987 9018338 71.43 µM 3.17137337621048 0.0418021223920383 no 391 0.000758599980959837 56 5055682
SGTC_2064 5220758 200 µM 3.1702887580862 0.041856492659576 no 392 0.000761437585791595 75 788518
SGTC_1594 piperine 70.1 µM 3.15054223142996 0.042856404989235 no 393 0.000814838471377388 45 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2014 4013930 200 µM 3.14405926349765 0.0431888638819322 no 394 0.0008331084602858 77 64556
SGTC_3160 9100216 49.47 µM 3.14321874147479 0.0432321195744321 no 395 0.000835504582757202 17 17191039
SGTC_1673 st016611 27.3 µM 3.13869873930652 0.0434653322635997 no 396 0.000848499078480564 85 5226799
SGTC_2345 9052315 157.45 µM 3.13769123186615 0.0435174534820997 no 397 0.000851420769707801 54 6469265
SGTC_2966 9084041 48.03 µM 3.13246171014134 0.0437888025167594 no 398 0.000866735182414738 74 17741380
SGTC_3210 9128157 49.47 µM 3.12851519387747 0.0439944814625591 no 399 0.000878459636035419 93 17590849
SGTC_383 2324-0395 7.37 µM 3.12591857596848 0.0441302327395702 no 400 0.000886253106658848 82 3146421
SGTC_18 0111-0177 500 nM 3.12098602023408 0.0443890368933989 no 401 0.000901232953460135 116 721752
SGTC_2443 5493264 126.67 µM 3.1093008054361 0.0450070254035679 no 402 0.000937653437859423 51 5340055
SGTC_2211 7117706 200 µM 3.10679089719235 0.0451406646291466 no 403 0.000945650631683429 33 822771
SGTC_2634 4'-methoxyflavone 100 µM 3.10246667954073 0.0453716549501447 no 404 0.000959575756563176 73 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1034 k072-0165 12.7 µM 3.09967553267821 0.0455212561712821 no 405 0.000968663722496231 62 5835461
SGTC_937 3122-0005 46.7 µM 3.09635908874601 0.0456995278734454 no 406 0.000979564762101848 57 759535
SGTC_3073 9114972 49.47 µM 3.08881955692284 0.0461068952099742 no 407 0.00100476725105793 37 41905075
SGTC_3267 9137951 49.47 µM 3.08724496617713 0.0461923387770182 no 408 0.0010101051995301 23 16643986
SGTC_1242 0402-0103 60.1 µM 3.07904811363182 0.0466391886478394 no 409 0.00103831570686491 62 432868
SGTC_2820 7989630 71.43 µM 3.0780097053808 0.0466960439878146 no 410 0.00104194064062899 49 2984098
SGTC_651 3253-0966 34.4 µM 3.07765185310372 0.0467156501365117 no 411 0.00104319253841223 74 781462
SGTC_3125 9127534 49.47 µM 3.07412287003312 0.0469093513322001 no 412 0.00105561230587095 34 1639235
SGTC_1653 st012112 65 µM 3.06121536691262 0.0476233195148908 no 413 0.00110220235585642 40 720429
SGTC_814 3342-0569 96 µM 3.05883651995268 0.0477558485184599 no 414 0.00111099183303038 71 4346283
SGTC_2564 betulinic acid 100 µM 3.05699623729005 0.0478585757926866 no 415 0.00111783541186106 71 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_526 4469-0568 170 µM 3.04879473089133 0.0483185488009244 no 416 0.00114880706869754 73 2901964
SGTC_2603 homopterocarpin 100 µM 3.04705777170073 0.0484164166815438 no 417 0.00115546644987552 101 101795 A weak amylase inhibitor.
SGTC_1654 st012436 41.8 µM 3.04397463740313 0.0485905243535006 no 418 0.00116737411422622 41 4323132
SGTC_1404 3909-7820 48.3 µM 3.03895069106758 0.0488753036598217 no 419 0.00118701853957997 34 23741373
SGTC_2352 9027995 87.8 µM 3.03834625104714 0.0489096556688347 no 420 0.00118940228217185 62 2997347
SGTC_2113 5491891 107.031 µM 3.02891998231602 0.0494478771314642 no 421 0.00122714839538959 73 789979
SGTC_232 clozapine 119 µM 3.02663867218123 0.0495788434647007 no 422 0.0012364468162713 108 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2332 7982454 138.89 µM 3.02369817743728 0.0497480607137253 no 423 0.00124852711028142 103 2981748
SGTC_2476 5806916 10.51 µM 3.01402441211616 0.0503080122607756 no 424 0.0012890353028306 50 2870194
SGTC_1420 4'-methoxyflavone 42 µM 3.00426070623924 0.0508782516822201 no 425 0.00133113545261126 39 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1728 st035614 33.7865 µM 2.98042937959007 0.0522917133321437 no 426 0.0014392229965995 115 15945546
SGTC_2376 9072922 81.32 µM 2.96685125971754 0.0531108845627757 no 427 0.00150433235407462 78 17087968
SGTC_2112 5488546 200 µM 2.95826869550238 0.0536338992349371 no 428 0.0015468616235249 61 600757
SGTC_2031 5180455 200 µM 2.95778153720366 0.0536637082048914 no 429 0.00154930821144429 48 29949
SGTC_2960 9079389 5.97 µM 2.95624051992182 0.0537580886919644 no 430 0.00155707070154094 73 16457355
SGTC_2744 captopril 92.04 µM 2.95599195361304 0.0537733245828197 no 431 0.00155832610817354 32 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2214 7179297 48.276 µM 2.95455646166835 0.0538613800816554 no 432 0.0015655942611458 25 769744
SGTC_2880 9042983 58.44 µM 2.95303840172048 0.0539546246142029 no 433 0.00157331408095765 79 6464714
SGTC_1563 conessine 56.1 µM 2.95120687442339 0.0540672934557708 no 434 0.00158267416244493 58 441082 An anti-amoebic, histamine inhibitor.
SGTC_631 k072-0230 41.5 µM 2.94451804858352 0.0544803481448459 no 435 0.0016172904006446 68 5773147
SGTC_2395 5646831 180.19 µM 2.94325921152876 0.0545583633743438 no 436 0.00162388179848388 71 6808628
SGTC_2851 9015922 71.43 µM 2.94186556180016 0.0546448365080791 no 437 0.00163120763007239 98 2996893
SGTC_1558 st069300 45.6 µM 2.94002041035994 0.054759491082373 no 438 0.00164095313711564 33 24208000
SGTC_1299 1079-1439 3.74 µM 2.92692147774721 0.0555789124096293 no 439 0.00171167650031045 60 323161
SGTC_24 0417-1663 219 µM 2.9094913306415 0.0566842517750077 no 440 0.00181008713509053 57 4329390
SGTC_285 1486-1325 46 µM 2.89804936386507 0.0574192141993646 no 441 0.00187745742128404 61 22310230
SGTC_2195 6536160 144.242 µM 2.8957070962032 0.0575705876718632 no 442 0.00189152659639734 53 3834386
SGTC_3250 9135583 49.47 µM 2.88677961191324 0.0581504229438144 no 443 0.00194603373949384 42 7699353
SGTC_1079 idarubicin 2.36 µM 2.88040402448769 0.0585673151339199 no 444 0.00198582926494369 57 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1410 3909-8106 77.9 µM 2.86833746886555 0.0593627527643372 no 445 0.00206317572684989 45 1039210
SGTC_2850 9015429 58.44 µM 2.86100461119785 0.0598502630629794 no 446 0.00211150454860593 69 6457570
SGTC_1648 st011736 69.8 µM 2.84806472214127 0.0607181892570275 no 447 0.00219929890763169 56 2855514
SGTC_565 1418-0001 44.5 µM 2.83991067582626 0.0612701473008584 no 448 0.00225630839226456 86 2862145
SGTC_1572 epiandrosterone 68.9 µM 2.83795337064245 0.0614032215619285 no 449 0.00227019075237463 75 441302 A steroid.
SGTC_1628 st004252 77.7 µM 2.83784898095355 0.0614103251980344 no 450 0.00227093331418419 80 692968
SGTC_1327 1436-0082 2.18 µM 2.82002444343877 0.0626327115923357 no 451 0.00240099957335668 69 15992205
SGTC_1298 1079-1278 263 µM 2.81299436374019 0.0631200095729513 no 452 0.00245412557355592 67 2840950
SGTC_647 0140-0236 81 µM 2.81144872880255 0.0632275419235371 no 453 0.00246594751453134 53 990837
SGTC_1795 st049545 62.3 µM 2.80760911086387 0.0634952877164173 no 454 0.00249553843197393 58 5291882
SGTC_1039 k821-0043 94 µM 2.80270654572098 0.0638384370224477 no 455 0.00253378779742432 86 15992768
SGTC_3081 9117243 49.47 µM 2.80125345874951 0.0639404207719391 no 456 0.00254522603162937 66 45595589
SGTC_1238 0333-0287 48.8 µM 2.80062798216363 0.0639843583331988 no 457 0.00255016393595289 92 7226
SGTC_739 1486-1183 203 µM 2.79748346364457 0.0642056056493664 no 458 0.00257512017557659 61 4346692
SGTC_1928 4'-methoxychalcone 40.3 µM 2.79066894313963 0.0646871134502222 no 459 0.00262996208680332 53 641818
SGTC_629 3448-6466 76.7 µM 2.78987349555211 0.0647435013529072 no 460 0.00263643198171721 79 573744
SGTC_1650 st011916 45.8 µM 2.78764311148393 0.0649018129857686 no 461 0.00265464989782355 54 242528
SGTC_1816 st051957 91.6 µM 2.78706210164835 0.0649431020950362 no 462 0.00265941425189377 59 674121
SGTC_1510 1123-0200 71.5 µM 2.78057021304606 0.0654058320582024 no 463 0.00271317619768391 121 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1852 st056254 31.4 µM 2.77926521447501 0.0654991579290218 no 464 0.00272410113410454 64 442583
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.76474050552879 0.0665448637301647 no 465 0.00284840471856324 91 2333 A French combination drug.
SGTC_1905 st060207 84.5 µM 2.76459050330361 0.0665557301615538 no 466 0.00284971471435637 62 1948547
SGTC_2923 7992654 58.14 µM 2.76342633612894 0.0666401112302638 no 467 0.0028599000785659 92 2985126
SGTC_1888 azatryptophan 97.5 µM 2.76251625138022 0.066706133562286 no 468 0.00286788531376474 61 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_101 0490-5701 117.494 µM 2.76018810221845 0.0668752601154954 no 469 0.00288840447041615 70 4661669
SGTC_2954 9074818 52.69 µM 2.75640453155482 0.0671508219945624 no 470 0.00292203349716246 98 16648742
SGTC_918 glabranin 770.725 nM 2.75505111446971 0.0672496058729334 no 471 0.00293414834628447 98 124049 Also referred to as licorice root.
SGTC_2270 7924575 90.91 µM 2.74348410212776 0.0680984536713652 no 472 0.00303954958619179 83 1262135
SGTC_3233 9132340 49.47 µM 2.74009007695718 0.0683490880589802 no 473 0.00307111740579613 76 17682950
SGTC_1320 1313-0481 95.3 µM 2.70986310271301 0.0706127213999928 no 474 0.00336554918974664 78 6813365 YLR208W SEC13
SGTC_711 k292-0785 179 µM 2.70707587026441 0.0708243190521142 no 475 0.00339393713143699 81 4146315
SGTC_443 clozapine 122 µM 2.70530439074207 0.0709590570216381 no 476 0.00341209129890914 47 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_358 0075-0058 9.45 µM 2.67893114490346 0.0729883535396356 no 477 0.00369287898982235 177 1069125
SGTC_3132 9126706 49.47 µM 2.67567242131996 0.0732421495671678 no 478 0.00372897501075825 100 850858
SGTC_399 oxolinic acid 75 µM 2.67206456995 0.0735239233052134 no 479 0.00376930704799728 54 4628 A DNA gyrase inhibitor.
SGTC_1059 3448-6867 171 µM 2.66728472900113 0.0738985052296571 no 480 0.00382334293949617 74 3934407
SGTC_2528 xanthyletin 44.79 µM 2.65106343225386 0.075180596949072 no 481 0.00401193851394245 89 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3116 9124943 49.47 µM 2.64438564218392 0.0757132945027149 no 482 0.00409196778098616 81 41905195 YPL160W CDC60
SGTC_3057 9095946 49.47 µM 2.63715535329155 0.0762933024158628 no 483 0.00418022666324576 57 24540043
SGTC_1772 st048439 82.2 µM 2.63409059659525 0.0765401726355904 no 484 0.00421814872416072 114 2927068 YDL195W SEC31
SGTC_3178 9107506 49.47 µM 2.63408447591014 0.0765406662721455 no 485 0.00421822476588601 87 8897194
SGTC_1540 guanosine 70.6 µM 2.62844838739354 0.076996248445702 no 486 0.0042887685358887 67 6802 Guanosine is a purine nucleoside
SGTC_501 nsc-95397 161 µM 2.62204218590707 0.0775165805970207 no 487 0.00437023055730044 72 262093
SGTC_1753 st043925 64 µM 2.62202556846282 0.0775179337825053 no 488 0.0043704436524807 75 670181
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.62114672385618 0.0775895250902236 no 489 0.00438172682877403 101 688751
SGTC_2826 7992541 19.48 µM 2.61197542827759 0.0783396234874694 no 490 0.00450103619832892 99 2985066
SGTC_2035 5154463 94.595 µM 2.60627077745554 0.0788089594105816 no 491 0.00457670339349817 108 2769623
SGTC_844 0330-0132 15.3 µM 2.60475501717773 0.0789340223249116 no 492 0.00459699862013821 74 2828079
SGTC_2813 7971799 71.43 µM 2.60431521400794 0.0789703378926263 no 493 0.00460290236702363 105 2234054
SGTC_3045 9092950 49.47 µM 2.59964384048345 0.079356845462821 no 494 0.004666027967956 100 44120432
SGTC_843 0310-0051 143 µM 2.59347135022652 0.0798697486851475 no 495 0.00475062274706354 93 2065037
SGTC_2662 daunorubicin 22.37 µM 2.59049939724001 0.0801175955594771 no 496 0.00479183946995238 92 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2159 5658611 73.75 µM 2.58998367910062 0.0801606631563468 no 497 0.00479902411625968 60 793844
SGTC_821 1114-0266 29.2 µM 2.5826379784792 0.0807760034846859 no 498 0.00490240735805981 97 3123235
SGTC_2189 6047310 154.431 µM 2.58195406764447 0.0808334748531249 no 499 0.004912132969421 81 711535
SGTC_1796 st049173 110.4 µM 2.57988848783338 0.0810072400228503 no 500 0.00494161118095673 57 94134
SGTC_1049 3226-0134 66 µM 2.57611246796795 0.0813256230926343 no 501 0.00499590700818213 142 5702385
SGTC_49 0717-0965 32.132 µM 2.56933096723278 0.0818997881907884 no 502 0.00509475442524088 108 5889349 YGL099W LSG1
SGTC_3085 9117376 49.47 µM 2.5666492783533 0.0821276780299251 no 503 0.00513432075752248 89 16480349
SGTC_1408 3909-7976 48.8 µM 2.56006290409219 0.0826894148531043 no 504 0.00523266092833347 124 24152374
SGTC_1124 fisetin 1.16336 µM 2.54666704117952 0.0838408309108642 no 505 0.00543785733372821 125 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_252 miconazole 1.30953 nM 2.52750258448681 0.0855089545885979 no 506 0.00574384892400096 131 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2493 resveratrol 26.09 µM 2.52399669688618 0.0858167871230171 no 507 0.00580145094212046 74 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_564 3555-0129 330 µM 2.52200863017715 0.0859917163769982 no 508 0.0058343422713183 55 563260
SGTC_617 3770-0098 35 µM 2.50685230995732 0.0873340951649226 no 509 0.00609057983926496 88 5962639
SGTC_2518 prenyletin 46.28 µM 2.50290901701658 0.0876858994146335 no 510 0.00615886023815728 56 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1957 st077035 62.4 µM 2.4965222904232 0.0882579380140692 no 511 0.00627088930448412 90 705593
SGTC_3335 9143315 29.6265 µM 2.48445932042914 0.0893459597709898 no 512 0.00648741657325108 97 4899691
SGTC_2411 st077133 39.94 µM 2.47680706147575 0.0900413103225282 no 513 0.00662817704979615 148 1403142 YNL221C POP1
SGTC_1328 1441-0025 69.2 µM 2.4678781567736 0.0908577417385304 no 514 0.00679582872647259 82 4562601
SGTC_3152 9099253 49.47 µM 2.46461875697929 0.0911571356007654 no 515 0.00685795514615838 274 25236131
SGTC_2041 5107442 45.335 µM 2.46204972361712 0.0913936305998891 no 516 0.00690727565790256 145 793005
SGTC_3194 9111903 49.47 µM 2.45934353012901 0.0916432435761859 no 517 0.00695956786594145 121 17087251
SGTC_487 nimodipine 119 µM 2.45184927218513 0.0923371323370468 no 518 0.00710620906696267 61 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2273 7815444 169.05 µM 2.45040523063284 0.092471280874555 no 519 0.00713477602097 115 2824616
SGTC_261 5-fluorouridine 15.376 µM 2.43774992402106 0.0936531076666143 no 520 0.00738949705311873 136 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2187 6125751 200 µM 2.43256844702544 0.0941401890344006 no 521 0.00749607880150974 114 874498
SGTC_1325 1431-0015 227 µM 2.43218237239319 0.0941765564033972 no 522 0.00750407420752803 110 1103340
SGTC_54 0159-0055 9 µM 2.4309651812464 0.0942912809374799 no 523 0.0075293308047716 128 3319099
SGTC_2238 6671620 73.2395 µM 2.43067787754063 0.0943183753493934 no 524 0.00753530323963639 125 729941
SGTC_1833 st055984 71 µM 2.42339087448455 0.09500750311071 no 525 0.00768818609744891 114 676288
SGTC_2699 st077704 54.6 µM 2.41112911274751 0.0961754504919287 no 526 0.00795160874457084 164 645852
SGTC_2918 7977171 22.06 µM 2.40787075861134 0.0964875802902981 no 527 0.00802293012179733 123 2236483
SGTC_3171 9103192 49.47 µM 2.40525983457377 0.0967382270047823 no 528 0.00808048529602097 66 13018434
SGTC_1368 1852-0141 284 µM 2.40474905860926 0.0967873169805266 no 529 0.00809178717952033 149 2838987
SGTC_793 0488-0545 106 µM 2.40346376979325 0.0969109252487103 no 530 0.00812028810905522 134 292548
SGTC_986 1493-0483 84 µM 2.40194920129041 0.0970567324181799 no 531 0.0081539864483123 104 40079
SGTC_2005 4024620 188 µM 2.40179923053871 0.097071178825461 no 532 0.00815732989388268 121 236743
SGTC_2769 toremifene 3.73 µM 2.39092584849039 0.0981228014975294 no 533 0.00840297336664035 126 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1384 3089-0840 101 µM 2.39012044892626 0.0982010267185612 no 534 0.00842142401735959 114 1069836
SGTC_1335 1486-0900 202 µM 2.38747546706255 0.0984582445176216 no 535 0.00848226748635324 152 X1335
SGTC_176 1486-1328 72.834 µM 2.38439098889533 0.0987588248840781 no 536 0.00855370780616924 201 22310231
SGTC_2118 5526350 200 µM 2.38408973992168 0.0987882173555184 no 537 0.008560713319829 130 743594
SGTC_1184 1269-1718 139 µM 2.38393449592874 0.0988033668096861 no 538 0.00856432546783024 117 5403821
SGTC_78 0336-0123 156.75 µM 2.38052729719318 0.0991362858367345 no 539 0.00864394006466636 112 6765896
SGTC_1693 xanthone 101.9 µM 2.37996395388436 0.0991914093250367 no 540 0.00865716582061373 124 7020 An insecticide.
SGTC_1189 1431-2119 7.28 µM 2.37986514023484 0.0992010806113746 no 541 0.00865948752273886 176 3107275
SGTC_2126 5251174 33.877 µM 2.37954969183736 0.0992319594195411 no 542 0.00866690287813549 190 790722
SGTC_312 4092-0653 6.84 µM 2.37633727980849 0.0995468183024168 no 543 0.00874273585144419 220 1148278
SGTC_2883 9059145 45.46 µM 2.37492488109106 0.0996854828995168 no 544 0.00877626097429261 93 16476510
SGTC_1770 st043884 66.3 µM 2.36497752458756 0.100666079933102 no 545 0.009015582577051 128 670149
SGTC_1782 st039423 80.636 µM 2.36104772651536 0.101055406720802 no 546 0.00911169258048053 153 2068169
SGTC_3272 9137413 49.47 µM 2.35978484034171 0.101180754116505 no 547 0.00914276853176775 121 17614870
SGTC_773 4358-1457 44.6 µM 2.35569860249222 0.101587108790806 no 548 0.00924395566538682 179 1186886
SGTC_930 2810-3379 265 µM 2.35208424970925 0.101947526359602 no 549 0.00933427301703406 141 1015764
SGTC_23 0213-0011 39.996 µM 2.35140019178511 0.102015844138767 no 550 0.0093514532317956 129 627608
SGTC_2484 5809818 12.04 µM 2.35046492444113 0.102109304440634 no 551 0.00937498737109752 118 2870548
SGTC_2303 7774051 200 µM 2.34747046108103 0.102408957063729 no 552 0.00945068591004878 137 2953184
SGTC_1691 st019933 84.6 µM 2.3463726687551 0.102518971950792 no 553 0.00947857115635994 116 6176082
SGTC_1333 1482-0047 286 µM 2.33824320715125 0.103336338185846 no 554 0.00968731764854286 154 3811116
SGTC_2758 dehydroepiandrosterone 69.35 µM 2.33567401634649 0.10359563538442 no 555 0.00975411885784102 162 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_42 0133-0086 60.653 µM 2.33553049028774 0.103610134754289 no 556 0.00975786250061296 128 162923 Model of phenazepam hydroxylation.
SGTC_1813 st051246 8.6015 µM 2.33156616254896 0.104011203521635 no 557 0.00986176282838317 102 5291959
SGTC_3214 9129694 49.47 µM 2.32957759200595 0.104212809523389 no 558 0.00991424381261621 155 17158655
SGTC_1243 0416-0003 5.65 µM 2.32462471834972 0.104716174614081 no 559 0.0100460179412754 172 2141977
SGTC_3317 9138495 8.753 µM 2.32226671547544 0.104956438359487 no 560 0.010109289301782 145 17020139
SGTC_3058 9093861 49.47 µM 2.31619116542751 0.105577331959432 no 561 0.0102739166739237 152 17217477
SGTC_3139 9095020 49.47 µM 2.3112608888321 0.106083132685492 no 562 0.0104092244737113 80 25236292
SGTC_8 0354-0001 70 µM 2.31012139346002 0.106200283025456 no 563 0.0104407171718547 248 4993152
SGTC_3008 9078912 71.4286 µM 2.3089919443343 0.106316492711104 no 564 0.0104720141324489 131 16648731
SGTC_910 3454-3003 490 µM 2.30583113602087 0.106642198196192 no 565 0.0105600348601003 158 820824
SGTC_1934 st074720 32.6 µM 2.30410408622105 0.106820466006885 no 566 0.0106084007142706 205 17250992
SGTC_2271 7849410 118.62 µM 2.2969541111196 0.10756078133838 no 567 0.010810693826538 128 972430
SGTC_2705 st078069 42.8 µM 2.29083250076424 0.108197550715685 no 568 0.0109865515612734 122 1530061
SGTC_2678 equilin 100 µM 2.28993637247051 0.108290993113351 no 569 0.0110125026811228 153 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.28606176123601 0.108695680657376 no 570 0.0111253228202024 86 88881 An O-methylated flavonoid and antioxidant.
SGTC_799 1310-0557 151 µM 2.28370177660358 0.108942703906614 no 571 0.0111945317905558 163 5354492
SGTC_1820 st053765 18.6 µM 2.28222577668213 0.10909740408635 no 572 0.0112380070052402 147 3690829
SGTC_1434 4073-0095 163 µM 2.27455327150581 0.109904106093825 no 573 0.0114663709935594 119 24133745
SGTC_2381 9035592 200 µM 2.26011067881847 0.111434223019828 no 574 0.0119071912704785 144 4749657
SGTC_3288 9119690 36.221 µM 2.23810013941089 0.113795348036844 no 575 0.012607262788572 141 17595618 YKL019W RAM2
SGTC_1171 0368-0077 21.4 µM 2.23485431536541 0.11414653013286 no 576 0.0127134573152084 124 3239779
SGTC_2432 5630864 12.22 µM 2.23353700395701 0.114289276698343 no 577 0.0127567764634197 185 5714970
SGTC_1717 st033143 58.0435 µM 2.22965815171387 0.114710335149034 no 578 0.0128850730495001 214 674616
SGTC_1104 tacrolimus 29.8 µM 2.2278530043518 0.114906664015734 no 579 0.0129451594659761 177 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_269 exalamide 29 µM 2.22575553227745 0.115135086345859 no 580 0.0130152804218708 120 3316 A derivative of salicylamide.
SGTC_428 3448-4153 16.5 µM 2.22235889073931 0.115505677366186 no 581 0.0131295305970874 176 3834874
SGTC_3305 9127027 53.8275 µM 2.21678953713474 0.116115155167159 no 582 0.0133187384142269 168 41905295
SGTC_790 1575-0012 79.1 µM 2.21622127903379 0.116177470134807 no 583 0.0133381756214241 179 378741 YLR208W SEC13
SGTC_506 n9-isopropylolomoucine 153 µM 2.20997320675269 0.116864196801633 no 584 0.0135535109247865 153 6610355
SGTC_3009 9080819 71.4286 µM 2.20799672081279 0.11708203055685 no 585 0.0136222508774127 169 17027216
SGTC_1939 st074455 53.6 µM 2.20382323786294 0.117542945922112 no 586 0.0137683888305425 189 1644229
SGTC_2804 7954240 19.48 µM 2.19553330519335 0.11846228455286 no 587 0.0140626822619016 190 828705
SGTC_2519 cryptotanshinone 88.04 µM 2.19081237909345 0.118988092237202 no 588 0.0142326862190395 129 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_763 3453-1109 128 µM 2.18652375085088 0.119467178068166 no 589 0.0143886544947829 169 1560353
SGTC_1209 2323-2347 50.3 µM 2.17825656783464 0.120394547924162 no 590 0.0146934703624548 145 5412760
SGTC_2341 7987486 176.74 µM 2.17634063528808 0.120610189108494 no 591 0.0147648995940251 196 1258686
SGTC_1998 st075797 76.8 µM 2.17204689052188 0.121094443992685 no 592 0.0149260631310848 190 24208315
SGTC_164 4100-3994 89.624 µM 2.16882459442285 0.121458756564284 no 593 0.0150480016378506 223 4615967
SGTC_947 3447-0010 211 µM 2.16256034505973 0.122169195526535 no 594 0.0152875055160156 153 748350
SGTC_753 1322-0200 289 µM 2.1614373558106 0.122296863384382 no 595 0.0153307855546223 161 5403907
SGTC_3186 9110464 49.47 µM 2.16094313155871 0.122353079297851 no 596 0.0153498662905295 146 17018021
SGTC_2532 xanthone 78.9 µM 2.15881067286907 0.122595845380529 no 597 0.0154324290687632 176 7020 An insecticide.
SGTC_1241 0364-0022 50.8 µM 2.15647378868671 0.122862271783754 no 598 0.0155233441661812 193 4563895
SGTC_450 aminopyrene 156 nM 2.15414950739762 0.123127663812023 no 599 0.0156142245596509 212 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_628 1636-0253 16 µM 2.14059903912062 0.124682888137254 no 600 0.0161531931765926 223 4456143
SGTC_1192 1488-0095 21.4 µM 2.13357742858674 0.125494155851065 no 601 0.0164386936326728 170 915875
SGTC_1432 4049-0298 68.4 µM 2.12484251406156 0.126508508814693 no 602 0.0167998780164887 147 741646
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.12374878315139 0.12663592090941 no 603 0.0168455778943141 164 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2231 micatex 6.853 µM 2.12290062825479 0.126734786599279 no 604 0.0168810899043179 137 20737 An antifungal of unknown mechanism.
SGTC_1569 carminic acid 40.6 µM 2.11044651108233 0.128192699202928 no 605 0.0174099569147745 188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1895 st058434 18.3 µM 2.10519980480359 0.128810366450269 no 606 0.0176369596272062 178 5393175
SGTC_1345 1488-0192 31.4 µM 2.10487117170999 0.128849123292658 no 607 0.0176512618675192 186 658348
SGTC_896 0964-0007 44.5 µM 2.1039219739662 0.128961110899174 no 608 0.017692626915609 140 6756758
SGTC_1332 1480-0653 17.5 µM 2.09798845657053 0.129662684902872 no 609 0.0179530825495531 199 5749438
SGTC_1455 4262-0120 131 µM 2.09255105546285 0.130307915847713 no 610 0.0181946248116173 211 1529587
SGTC_2158 5657123 3.6195 µM 2.09159861905845 0.130421165243349 no 611 0.0182372180863129 143 2858827
SGTC_2284 7945075 39.21 µM 2.08615751639946 0.131069444482518 no 612 0.0184821785534342 226 1245402
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.08301865087879 0.131444434956581 no 613 0.0186247617714648 167 756377
SGTC_2164 5685496 200 µM 2.08293224509714 0.131454768050185 no 614 0.0186286999672665 179 759046
SGTC_1705 st027868 56.3335 µM 2.08285902443393 0.131463524800938 no 615 0.0186320377676437 167 292948
SGTC_274 sirtinol 40.1 µM 2.0804849121036 0.131747672576008 no 616 0.0187405390561834 193 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_811 0416-0114 265 µM 2.07531049045302 0.132368445382618 no 617 0.0189788839105979 212 6612453
SGTC_2521 angolensin 13.4 µM 2.07238497090556 0.132720309197254 no 618 0.0191147769098473 160 821428 A flavenoid.
SGTC_205 1486-1330 71.903 µM 2.07090616318295 0.132898416160295 no 619 0.0191837830534442 139 4118834
SGTC_3212 9128307 49.47 µM 2.07071360890166 0.132921619418229 no 620 0.0191927838472538 217 27243542
SGTC_3019 9081971 49.47 µM 2.06864626545051 0.133170915051648 no 621 0.0192896465204815 179 16451803
SGTC_418 lividomycin a 100 µM 2.06770707838415 0.133284275430834 no 622 0.0193337879546733 176 72394 An antibiotic.
SGTC_1489 4065-0444 182 µM 2.06559934493814 0.133538921622462 no 623 0.0194331631736545 181 2877968
SGTC_1225 1216-0074 20.6 µM 2.06484182356631 0.13363052338243 no 624 0.0194689845659353 203 4241466
SGTC_1249 0481-0015 10.2 µM 2.06131363762279 0.13405773139632 no 625 0.0196365639904881 189 4227577
SGTC_3215 9129942 49.47 µM 2.05960569574214 0.134264873093175 no 626 0.0197181256414908 154 17682944
SGTC_2114 5491910 81.25 µM 2.05705344788312 0.134574822953398 no 627 0.0198405424635036 171 2849228
SGTC_2342 7990637 118.86 µM 2.05700057901748 0.134581248637479 no 628 0.0198430850859675 222 2033102 YER133W GLC7
SGTC_2333 9017922 200 µM 2.04397415712319 0.136170901861122 no 629 0.0204780501164067 209 3163164
SGTC_2382 9035899 200 µM 2.04078288382607 0.13656229424595 no 630 0.020636206303539 212 6462679
SGTC_3144 9087057 49.47 µM 2.04076140351499 0.136564931293751 no 631 0.0206372743409268 193 17249618
SGTC_1709 st033179 39.1045 µM 2.03830554055279 0.136866656913936 no 632 0.0207596930682796 211 573381
SGTC_1555 citronellol 128 µM 2.03034413190216 0.137847921200514 no 633 0.0211607856248927 139 8842 A terpine precursor.
SGTC_2024 5144227 134 µM 2.02916381959563 0.137993805278233 no 634 0.0212208036776259 238 3475211
SGTC_1272 0839-0021 27 µM 2.01836998974946 0.139332784102702 no 635 0.0217763712206695 221 5027250
SGTC_682 0kpi-0099 17 µM 2.01515258829111 0.139733608481442 no 636 0.0219443317577653 264 1714895 YML126C ERG13
SGTC_2083 5306046 65.942 µM 2.01269904536299 0.14003979758997 no 637 0.0220731499422413 250 539837
SGTC_1167 k781-0610 148 µM 2.00840045563494 0.140577337010054 no 638 0.0223003772647531 243 4525169
SGTC_1499 4480-0877 67.3 µM 2.00750711672269 0.140689224746494 no 639 0.022347846811949 142 2861909
SGTC_1661 st013063 9.66 µM 2.00215413519465 0.141360933804727 no 640 0.0226340783714725 243 721395
SGTC_934 2950-0684 338 µM 1.99592248629313 0.142145634845316 no 641 0.0229711803457176 227 1121253
SGTC_588 3970-1144 52.9 µM 1.99425714959162 0.142355835431223 no 642 0.0230619797500591 248 1888707
SGTC_507 nimesulide 162 µM 1.9930726953409 0.142505466426969 no 643 0.0231267437005336 220 4495 A COX2 inhibitor.
SGTC_828 2074-0507 139 µM 1.99282688353532 0.142536532925703 no 644 0.023140203444037 231 X828
SGTC_2440 5628896 157.78 µM 1.98783108085756 0.143168911311401 no 645 0.0234151875204809 193 5522048
SGTC_912 3474-0017 2.18 µM 1.98420739788456 0.143628788251156 no 646 0.023616362093097 227 3360550
SGTC_1706 st031321 9.9705 µM 1.97751247348964 0.144481052414406 no 647 0.023991865990399 180 6103185
SGTC_807 1315-0151 48 µM 1.97311141489188 0.145043159998969 no 648 0.024241435020752 264 4011080
SGTC_1963 st076565 50.3 µM 1.97257217669138 0.145112133129319 no 649 0.02427216278227 188 4914280
SGTC_2056 5235370 200 µM 1.96839814404287 0.145646773924571 no 650 0.024511122641642 248 5511916
SGTC_1202 1988-0068 29.6 µM 1.9649704794167 0.146086803518449 no 651 0.0247088271869736 251 2850480
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.96291583645839 0.14635099787201 no 652 0.0248279771596787 291 551469
SGTC_1193 1488-0126 41.5 µM 1.9600774174299 0.146716500746106 no 653 0.0249933711437545 245 1384710
SGTC_2162 5663267 200 µM 1.95425603578737 0.14746803407865 no 654 0.0253354726769915 194 6456493
SGTC_2843 9000894 45.46 µM 1.94455760005486 0.148725809149384 no 655 0.0259141232861333 128 2242070
SGTC_2593 nobiletin 86.24 µM 1.94333808550929 0.148884472109101 no 656 0.0259876613520915 219 72344 An anti-infammatory.
SGTC_1491 4138-0063 26.5 µM 1.94252738314613 0.148990009786485 no 657 0.026036644128021 170 23883227
SGTC_442 cape 100 µM 1.93912734619158 0.14943317269737 no 658 0.0262429168011122 185 5281787
SGTC_2709 st078560 56 µM 1.93721986557409 0.149682179787149 no 659 0.0263592364532612 217 17250903
SGTC_2176 5809774 33.9695 µM 1.93607288953571 0.149832041990288 no 660 0.0264293871857287 210 2870539
SGTC_2469 5655019 90.81 µM 1.93489142143516 0.149986515477421 no 661 0.0265018105629136 249 2788239
SGTC_2317 5986382 200 µM 1.92617236561447 0.151129789223484 no 662 0.0270414275702355 213 877883
SGTC_1233 0325-0408 14.2 µM 1.92385691143758 0.151434371631143 no 663 0.027186260740183 248 12874
SGTC_2639 lactacystin 53 µM 1.920103411649 0.151928985831409 no 664 0.0274224192280212 253 3870 A proteasome inhibitor.
SGTC_208 k072-0098 12.366 µM 1.91005309175411 0.153258636538189 no 665 0.0280631889099414 323 5948901
SGTC_1119 parthenolide 318.541 nM 1.90568945583617 0.153838336199446 no 666 0.0283452540613397 336 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2190 6049624 200 µM 1.90396982952112 0.154067182998229 no 667 0.0284570568042323 177 2265554
SGTC_1235 benzylparaben 21.5 µM 1.90122943103401 0.154432338721571 no 668 0.0286359838633931 242 7180
SGTC_1041 0206-0046 107 µM 1.89526316989395 0.155229315145838 no 669 0.0290287724638754 242 50494
SGTC_519 k048-0011 62.8 µM 1.89466837869846 0.155308916231603 no 670 0.0290681747671803 258 6836379
SGTC_1071 trifluoperazine 6.31 µM 1.89074116114129 0.155835173003324 no 671 0.0293294524881495 263 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3216 9129716 49.47 µM 1.88589944646604 0.156485590963848 no 672 0.0296542530690426 239 8056934
SGTC_1040 k898-0338 155 µM 1.88054047189645 0.157207576925944 no 673 0.030017227985338 291 20969351
SGTC_221 trifluoperazine 10.304 µM 1.87411618549833 0.158075968812972 no 674 0.0304572064659756 484 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2811 7967822 32.47 µM 1.87342425285662 0.158169687098552 no 675 0.0305049117759564 258 2232244
SGTC_2015 5119600 184 µM 1.87148940115818 0.158431945116677 no 676 0.0306386387927697 268 2828786
SGTC_2533 agelasine 13.65 µM 1.86257336390604 0.159644146343801 no 677 0.0312611573766222 299 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1603 st002045 67.8 µM 1.86047724660577 0.159930007873764 no 678 0.031409017349221 248 5887985
SGTC_3148 9097893 49.47 µM 1.85643196111717 0.160482636403545 no 679 0.0316960063206044 287 17174100
SGTC_1430 4049-0248 69.1 µM 1.85549227134442 0.160611186255113 no 680 0.0317629809351426 287 22774488
SGTC_3111 9122088 49.47 µM 1.85319539697481 0.160925682410981 no 681 0.0319271786012404 165 16876704
SGTC_1737 st035557 69.7 µM 1.84902590779086 0.161497610073225 no 682 0.0322270359058772 212 5716916
SGTC_1256 0570-0116 285 µM 1.84421054699297 0.162159778871955 no 683 0.0325762309423405 251 410638
SGTC_317 4495-0002 170 µM 1.83938581120045 0.162825007391151 no 684 0.0329292297838337 239 15991618
SGTC_1887 st057648 70.8 µM 1.82375099652148 0.164992891063301 no 685 0.0340948626566187 258 688672
SGTC_2081 5214970 32.255 µM 1.82332190565599 0.16505265001956 no 686 0.0341273252221153 259 2063512
SGTC_1435 4092-0789 56.7 µM 1.82207579849157 0.165226273255424 no 687 0.0342217426588031 247 2248285
SGTC_1587 estradiol valerate 56.1 µM 1.82148466244175 0.165308679045971 no 688 0.034266608022633 275 13791 A steroid.
SGTC_1507 4075-3230 155 µM 1.81231026569761 0.166591020500851 no 689 0.0349691346191048 210 659771
SGTC_1671 st016596 74.5 µM 1.81120284542282 0.166746242102373 no 690 0.0350547289615302 300 2829167
SGTC_3307 9126885 69.2785 µM 1.80715212229156 0.167314806505607 no 691 0.0353692818195167 320 24824909
SGTC_2038 4100038 30.985 µM 1.80305660002545 0.167890927690726 no 692 0.0356896630697119 312 3596803
SGTC_2848 9016370 25.97 µM 1.79450301871461 0.169098281907779 no 693 0.0363664586119094 312 7894410
SGTC_935 2996-0153 430 µM 1.77581644592642 0.171755269841138 no 694 0.0378815880620882 277 23738523
SGTC_611 3453-1652 23.7 µM 1.77531517721135 0.171826909051778 no 695 0.0379229303885288 336 1560575
SGTC_1088 bifonazole 369 nM 1.77467328233407 0.171918673819773 no 696 0.0379759246584801 261 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_769 0302-0231 76 µM 1.77289420226128 0.172173173170886 no 697 0.0381231197800571 378 571869 YER009W NTF2
SGTC_2302 7771753 200 µM 1.77001985678236 0.172584859170939 no 698 0.0383619164572681 352 2203047
SGTC_1334 1486-0610 236 µM 1.76978775038478 0.172618130612419 no 699 0.0383812526306747 314 3742339
SGTC_2772 vinpocetine 57.06 µM 1.76690658009722 0.173031474244458 no 700 0.0386219374308876 299 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1365 1672-3266 55.4 µM 1.76542248979509 0.173244633314367 no 701 0.0387463931958679 308 6415873
SGTC_1087 pterostilbene 9.05 µM 1.76520457324584 0.173275946620909 no 702 0.0387646951479741 315 5281727 Similar to reservatol, lowers cholesterol.
SGTC_475 α-linolenic acid 10 µM 1.75917091332115 0.174144378478339 no 703 0.0392742415373141 320 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_967 1306-0166 352 µM 1.75284803272275 0.175057401276756 no 704 0.0398140478943011 320 4437607
SGTC_595 3909-8003 73.7 µM 1.74376880117648 0.176373741272352 no 705 0.0405997063840682 306 699517
SGTC_451 chloral hydrate 100 µM 1.74020520354405 0.176892111536344 no 706 0.0409114961300638 393 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2163 5671233 125 µM 1.73897962372156 0.177070609883152 no 707 0.0410191735652 328 701023
SGTC_1546 5-methoxyflavanone 78.7 µM 1.73826108657314 0.177175313402782 no 708 0.0410824098679959 300 147795
SGTC_1790 st045711 43.5 µM 1.73806088623132 0.177204493083447 no 709 0.0411000429753933 298 585119
SGTC_1358 1509-0022 2.48 µM 1.73122319524704 0.178202924664245 no 710 0.0417059819347887 297 3258434
SGTC_2406 ethylparaben 405.7 µM 1.7305096171279 0.178307324432727 no 711 0.0417696322431265 286 8434 A possible steroid mimic.
SGTC_3067 9117431 49.47 µM 1.72807075599808 0.178664431948574 no 712 0.0419877698623978 256 17150885
SGTC_134 0269-0018 6.916 µM 1.72800872810587 0.178673520181955 no 713 0.0419933297892401 413 4378915
SGTC_587 k089-0003 57 µM 1.72753475368234 0.178742975811103 no 714 0.0420358345995173 178 9659696
SGTC_2875 9039966 71.43 µM 1.72097993840279 0.179705252810268 no 715 0.0426272321804801 249 6463691
SGTC_1815 st051655 58.2 µM 1.71986983417768 0.179868542926801 no 716 0.0427280524940795 264 5984156
SGTC_1386 3228-0095 33.8 µM 1.71916206708601 0.179972700137142 no 717 0.0427924328805234 283 870181
SGTC_3091 9116372 49.47 µM 1.71776909898986 0.180177804260729 no 718 0.0429193699839532 300 17169793
SGTC_2347 9049783 174.81 µM 1.71649711595889 0.180365222342147 no 719 0.0430355476876295 366 6467988 YPL169C MEX67
SGTC_1106 tegaserod maleate 11.7 µM 1.71510599116841 0.180570335140461 no 720 0.0431628980489466 350 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3176 9106582 49.47 µM 1.70691641182964 0.181780801918315 no 721 0.0439187949558429 148 17018027
SGTC_2952 9073731 13.78 µM 1.70299168650585 0.182362693844205 no 722 0.0442848121029505 384 16457353
SGTC_1144 3486-0183 12.5 µM 1.70280582170084 0.182390279567352 no 723 0.04430220651383 339 6744069
SGTC_259 usnic acid 108.925 µM 1.70050900457566 0.182731384209361 no 724 0.044517612055667 341 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2627 acetyl isogambogic acid 100 µM 1.69977957422565 0.182839796559071 no 725 0.0445861974837382 323 6857789 A caspase activator and apoptosis inducer.
SGTC_186 3455-3465 67.277 µM 1.68320222390386 0.185314437487801 no 726 0.0461679752317251 203 755278
SGTC_1261 0712-0010 12.7 µM 1.67796932024935 0.18609989553641 no 727 0.0466765442191396 376 2840123
SGTC_1472 k841-0093 193 µM 1.67290085794045 0.186862635177526 no 728 0.0471734074459403 370 X1472
SGTC_1937 st074714 47.2 µM 1.66371166911399 0.188250416818385 no 729 0.0480850315977675 360 17250970
SGTC_1251 0490-5699 265 µM 1.66067371167858 0.188710614326537 no 730 0.0483894979401638 395 3883818
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.65058841453857 0.19024332658491 no 731 0.0494113230703356 243 4620898
SGTC_357 1325-0123 420 µM 1.64369688788315 0.191295051271393 no 732 0.0501194145649596 307 1098503
SGTC_2821 7996764 71.43 µM 1.63729284172846 0.19227556878626 no 733 0.0507846479521863 396 2987135
SGTC_2568 diosmetin 100 µM 1.63538688185124 0.192567981052511 no 734 0.0509839853154849 372 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_513 4245-1575 41.7 µM 1.6276337656371 0.193760262988859 no 735 0.0518012825120914 517 719745
SGTC_309 k408-0051 1.48 µM 1.62641699826707 0.193947786414217 no 736 0.0519304885981582 452 3640463
SGTC_1292 0kpi-0043 232 µM 1.62591545203036 0.194025114935835 no 737 0.051983821262778 348 3333905
SGTC_2718 lomofungin 53.02 µM 1.6167251384927 0.195445403448171 no 738 0.05296881253515 331 5351222 A RNA synthesis inhibitor.
SGTC_206 4546-0025 72.014 µM 1.6142108824079 0.195835058728234 no 739 0.0532408461633781 434 6620745 YIL048W NEO1
SGTC_1438 4092-1045 4 µM 1.61122352558716 0.196298646731487 no 740 0.0535655059881028 343 1351342
SGTC_2278 7948257 134.34 µM 1.60987458145438 0.196508198236345 no 741 0.0537126195623349 340 1247028
SGTC_230 MPP+ 141.667 µM 1.60677600781513 0.196990058671856 no 742 0.0540517565581143 349 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_397 arbidol 50 µM 1.60608668161847 0.197097353239858 no 743 0.054127432875207 385 131410 A RNA synthesis inhibitor.
SGTC_1339 1486-1321 22.7 µM 1.60459190505716 0.197330138722534 no 744 0.0542918220292699 377 3469382
SGTC_2742 clothiapine 36.27 µM 1.60090943193805 0.197904328980212 no 745 0.0546984901193316 294 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1708 st033234 31.827 µM 1.59702609857709 0.198510930478277 no 746 0.0551299448809515 382 674664
SGTC_784 4579-0127 173 µM 1.57579704417831 0.20184682431379 no 747 0.0575362919135388 391 1948547
SGTC_1142 3253-1408 9.78 µM 1.57339347404764 0.20222662057826 no 748 0.0578138685807749 365 256655
SGTC_3020 9089140 49.47 µM 1.57304828912271 0.202281199503248 no 749 0.0578538186254582 394 17217859
SGTC_898 1000-0849 28.3 µM 1.57239547319797 0.202384443598504 no 750 0.0579294317318467 361 6751807
SGTC_2865 9030313 51.95 µM 1.57036637613758 0.202705550339895 no 751 0.0581649500957771 349 42562754
SGTC_2704 st078022 71.1 µM 1.56894292251761 0.202930994964223 no 752 0.0583306196315459 370 54697681
SGTC_2354 9060492 162 µM 1.5642130374294 0.203681182461327 no 753 0.0588837732342787 418 6471895
SGTC_2981 9013952 38.96 µM 1.5634252535105 0.203806290051388 no 754 0.0589763020559816 378 2996344
SGTC_2566 crystal violet carbinol 226 nM 1.56101361711938 0.204189565523048 no 755 0.0592602689980963 353 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_70 0141-0289 43.283 µM 1.55782228636783 0.20469741524811 no 756 0.0596376907141746 646 352408
SGTC_3029 9088683 49.47 µM 1.55418307459193 0.205277454130895 no 757 0.0600703767923016 371 25236615
SGTC_1762 st045503 25.4615 µM 1.54777115622196 0.206301795748846 no 758 0.0608387016619575 409 4645554
SGTC_1560 lithocholic acid 53.1 µM 1.54760107153216 0.2063290089585 no 759 0.0608591866392651 285 9903 A bile acid which acts as a detergent.
SGTC_1956 st077085 54 µM 1.54649435915023 0.206506132672718 no 760 0.0609926106759768 439 24208685
SGTC_2077 5212015 200 µM 1.54538193699385 0.206684260948685 no 761 0.0611269534030519 408 780900
SGTC_2132 5317594 122.667 µM 1.54446053471546 0.206831870745538 no 762 0.0612384024411054 342 794577
SGTC_2203 7227154 166.4 µM 1.54258503099526 0.207132521501144 no 763 0.0614657461326041 351 896304
SGTC_3014 9081533 49.47 µM 1.54076497956034 0.207424530052413 no 764 0.0616869977925609 385 21367265
SGTC_74 000s-0487 160.283 µM 1.53983846389557 0.2075732733942 no 765 0.061799866783281 403 677548
SGTC_3137 9097352 49.47 µM 1.5342257222786 0.208475692658498 no 766 0.0624870658472128 440 44120435
SGTC_112 phenothiazine 287.218 µM 1.53235228658694 0.208777418757248 no 767 0.0627177624342677 398 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1118 chelidonine 707.474 nM 1.53166046518746 0.208888905047879 no 768 0.0628031215762213 418 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1863 st057641 20.1 µM 1.53042854910814 0.209087513837154 no 769 0.0629553434168541 424 3921635
SGTC_2483 5729050 27.16 µM 1.53025754135344 0.209115092393794 no 770 0.0629764967069821 497 2865180
SGTC_225 nsc-122657 1.016 µM 1.52301373237041 0.210285273006125 no 771 0.0638776349167316 259 275685
SGTC_1927 st060202 13.8 µM 1.52224685464012 0.210409380783641 no 772 0.0639736194790634 387 688887
SGTC_3033 9090887 49.47 µM 1.51907959881846 0.210922409445605 no 773 0.0643712306265617 449 19325384
SGTC_2994 9053520 71.4286 µM 1.51691156193714 0.211274008173526 no 774 0.0646445070451719 415 4647384
SGTC_2088 5278280 127.392 µM 1.51434289936817 0.211691021966129 no 775 0.0649694467084061 455 791502
SGTC_1090 efavirenz 20.7 µM 1.51347882560344 0.211831409667926 no 776 0.0650790378556803 403 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1278 0874-0585 172 µM 1.51225118715583 0.212030960057061 no 777 0.065234986839279 400 766306
SGTC_737 1950-0117 57.9 µM 1.5100077705891 0.212395907197299 no 778 0.065520720700048 411 5393513
SGTC_3312 9133330 71.43 µM 1.50980789912557 0.21242843902651 no 779 0.0655462244401389 413 17617324
SGTC_1232 0279-0259 161 µM 1.50694997881749 0.212893923187324 no 780 0.0659117396394484 427 1560000
SGTC_2018 5133068 143 µM 1.50308118048683 0.213525001661365 no 781 0.0664090555888458 425 785362
SGTC_2010 4012422 159 µM 1.49958325936877 0.214096519900414 no 782 0.0668611933856423 423 952393
SGTC_1030 k029-0042 36.7 µM 1.49370410222442 0.215059106355972 no 783 0.0676264879312996 464 6080581
SGTC_3201 9113999 49.47 µM 1.48913167428204 0.215809477872445 no 784 0.0682263492517207 431 16649224
SGTC_2947 9072639 7.68 µM 1.48787440568133 0.216016071250985 no 785 0.0683920092966762 482 16488146
SGTC_452 diindolylmethane 8 µM 1.48638267381824 0.216261339991556 no 786 0.068588965026238 365 3071 Inhibits expression of several cancer promoting factors.
SGTC_1418 3966-3099 2.4 µM 1.48514789444297 0.21646448282386 no 787 0.0687523256043572 458 740335
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.47773573134514 0.217686232121275 no 788 0.0697392632589069 419 7104
SGTC_1218 1348-1416 30.7 µM 1.47681139335594 0.217838869578857 no 789 0.0698631008197739 444 6787668
SGTC_194 1486-1323 56.904 µM 1.47680548735822 0.217839845044432 no 790 0.0698638926155964 430 5178754
SGTC_302 1094-0063 18.9 µM 1.47585717460422 0.21799650603086 no 791 0.0699911190909352 367 5440289
SGTC_1305 1181-0477 144 µM 1.47199678487959 0.218634911293135 no 792 0.0705108728952977 419 6252086
SGTC_1647 st011722 22.4 µM 1.47199089345725 0.218635886398658 no 793 0.0705116683638121 405 2854783
SGTC_321 4534-3890 65.3 µM 1.47155657712428 0.218707778184721 no 794 0.0705703293959358 411 699746
SGTC_2616 abietic acid 100 µM 1.47142020493646 0.218730354492097 no 795 0.0705887562718839 463 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_993 3909-8757 62.7 µM 1.46597557969039 0.21963280298989 no 796 0.0713274699155452 391 4288324 YLR208W SEC13
SGTC_2117 5521686 200 µM 1.4648100399788 0.219826269078606 no 797 0.0714863759451382 421 803312
SGTC_2746 daunorubicin 9.88 µM 1.46408127354509 0.219947285548514 no 798 0.0715858716264455 279 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1929 genistein trimethyl ether 50.5 µM 1.46157076957812 0.220364463835695 no 799 0.0719294346525974 426 136420
SGTC_1411 3909-8223 150 µM 1.46076139311554 0.220499057078618 no 800 0.072040467101503 447 X1411
SGTC_3012 9080433 71.4286 µM 1.46045664404608 0.220549746771422 no 801 0.0720823074368004 457 17688859
SGTC_755 1995-0008 37.3 µM 1.45935764736967 0.220732601146875 no 802 0.0722333482395024 430 689533
SGTC_235 0330-0087 5 mM 1.45599454889698 0.221292702673328 no 803 0.0726970632610617 487 46494818 YHR062C RPP1
SGTC_311 1315-0136 58 µM 1.45463883755977 0.221518716995957 no 804 0.0728846365758692 441 6759207
SGTC_1771 st048882 4.1505 µM 1.44875713765464 0.222500797850861 no 805 0.07370270880967 426 4580403
SGTC_2895 9054447 58.44 µM 1.44722534898957 0.222756971007782 no 806 0.0739169095570867 401 2697450
SGTC_2975 9084847 53.72 µM 1.44356959748385 0.223369030070997 no 807 0.0744300410361776 464 27211724
SGTC_2700 st077718 96.8 µM 1.44351010526283 0.223378998379309 no 808 0.0744384139619699 411 904970
SGTC_1831 st055328 12 µM 1.44187059856986 0.223653807971981 no 809 0.0746694409513298 446 1103068
SGTC_1055 3448-0672 86 µM 1.44059836285658 0.223867189017806 no 810 0.074849091606621 448 748378
SGTC_976 1348-1067 47.6 µM 1.4398707392925 0.223989278987895 no 811 0.0749519864513331 522 5310671 YGL099W LSG1
SGTC_2371 9071574 200 µM 1.43882880485467 0.224164173902108 no 812 0.0750995165085668 378 45596039
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.43618285432465 0.224608660853145 no 813 0.0754751582677883 450 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1860 st056228 74.6 µM 1.43584780838037 0.224664980067634 no 814 0.0755228262111649 437 688679
SGTC_3166 9102297 49.47 µM 1.43174536380811 0.225355225551062 no 815 0.0761083543223513 486 25237072
SGTC_1395 3486-0190 4.35 µM 1.42752499786201 0.226066562929268 no 816 0.0767143125101785 487 6748079
SGTC_3107 9121808 49.47 µM 1.42555783024991 0.226398559711828 no 817 0.0769980080038282 352 662681
SGTC_421 streptovitacin 30 mM 1.42415287623764 0.226635840761671 no 818 0.0772011113639139 508 91467 include heat shock
SGTC_3198 9112019 49.47 µM 1.42078356602182 0.227205451196603 no 819 0.0776898448631042 453 45595555
SGTC_2620 irigenin 100 µM 1.4200161333578 0.227335304920255 no 820 0.0778014921152546 496 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1625 st003711 30.1 µM 1.41745908010666 0.227768273686234 no 821 0.078174374983827 456 24207034 YER133W GLC7
SGTC_1643 st009866 20.2 µM 1.41581056181903 0.228047652156827 no 822 0.0784154882069773 409 3156273 YOR207C RET1
SGTC_770 0389-1121 67.2 µM 1.41509055329572 0.228169734226841 no 823 0.0785209738014062 534 6753108
SGTC_470 aa-861 153 µM 1.40963026333492 0.229096756524715 no 824 0.0793244430517311 517 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_714 4296-0578 26.1 µM 1.40877477180037 0.229242189035411 no 825 0.0794508886075909 353 1589775
SGTC_2365 9042475 200 µM 1.4042569649711 0.230011068588919 no 826 0.0801211721329609 496 6464479
SGTC_703 3875-0075 71.8 µM 1.40418668578298 0.230023040699495 no 827 0.080131632752756 475 2850814
SGTC_1113 artemisinin 1.17947 µM 1.40116073603119 0.230538844052957 no 828 0.0805830063423901 489 2240 An anti-malaria and mitochondrial poison.
SGTC_2179 6298986 200 µM 1.39707952990191 0.231235549125099 no 829 0.081194828349241 436 738374
SGTC_1347 1493-0251 600 nM 1.39577883311852 0.231457838413072 no 830 0.0813905531688941 524 3986378
SGTC_1677 st019204 53.9 µM 1.39419845921407 0.231728084820776 no 831 0.0816288415558832 459 3945625
SGTC_1624 st003710 6.25 µM 1.39192535755743 0.23211709686686 no 832 0.0819725011018724 550 24207033
SGTC_1842 st055362 61.2 µM 1.38981857610567 0.232477969701069 no 833 0.0822919878861342 523 676032
SGTC_1985 st071382 65.5 µM 1.38847816750543 0.232707732021177 no 834 0.0824957441936895 470 6123237
SGTC_1007 4101-0031 70 µM 1.38819875358105 0.232755642853849 no 835 0.0825382658672296 513 1146276
SGTC_2825 7998094 58.44 µM 1.38753289566937 0.232869838952755 no 836 0.0826396637298538 484 2987815
SGTC_1428 4049-0204 61.7 µM 1.38278002388002 0.233685870329976 no 837 0.0833661629604958 499 X1428
SGTC_1303 1160-0052 261 µM 1.38241776599667 0.233748132162998 no 838 0.0834217320978052 488 3562476
SGTC_2896 9052656 71.43 µM 1.38018436252068 0.234132193760965 no 839 0.0837649437311825 623 6469436
SGTC_2805 7950783 58.44 µM 1.37828482307344 0.234459118064317 no 840 0.0840576835754422 561 1178958 YDL195W SEC31
SGTC_2828 7998861 71.43 µM 1.37348269588027 0.235286723661783 no 841 0.0848011685295064 400 2988188
SGTC_1311 1190-0148 100 µM 1.37257232395778 0.235443800144124 no 842 0.0849426703309289 604 1961333
SGTC_803 4488-1585 147 µM 1.37254018108258 0.235449347165457 no 843 0.0849476696261593 464 747204
SGTC_1548 st061468 90.8 µM 1.37190151658722 0.235559578939834 no 844 0.0850470491130371 485 390799
SGTC_1716 st033144 30.6155 µM 1.37118015797227 0.235684117729361 no 845 0.085159400995167 532 674617
SGTC_1447 4239-0816 81.9 µM 1.36789643997312 0.236251493089343 no 846 0.0856722471359907 483 1341554
SGTC_1695 st026914 34.495 µM 1.36617192219638 0.236549763893477 no 847 0.0859425040632558 506 3289191
SGTC_794 k038-0031 316 µM 1.36401239047482 0.236923566288366 no 848 0.0862818330226425 597 6624242
SGTC_1453 4237-0541 195 µM 1.36298702580741 0.237101164583794 no 849 0.0864432997951925 494 739892
SGTC_75 0159-0059 199.013 µM 1.36009914890278 0.237601752236159 no 850 0.0868992751903977 494 5377270
SGTC_191 3914-0123 66.505 µM 1.35837511874496 0.237900873698385 no 851 0.0871723426099542 365 3144412
SGTC_1227 3909-8010 46.6 µM 1.35835216254814 0.237904858020726 no 852 0.0871759829368743 478 15982272
SGTC_2142 5622915 118.518 µM 1.35786843174683 0.23798882379099 no 853 0.0872527179609792 456 5322196
SGTC_2165 5727197 32.143 µM 1.35716879349497 0.238110295412076 no 854 0.0873637919459549 517 1361712
SGTC_2601 securinine 100 µM 1.35679310355573 0.238175536947388 no 855 0.087423479707368 495 442872 A GABA receptor antagonist.
SGTC_115 0527-0192 112.043 µM 1.35566784413779 0.238371005752736 no 856 0.0876024374751379 606 4233931
SGTC_1961 st076550 68.7 µM 1.35234740380084 0.238948311179851 no 857 0.0881321032591663 455 1579337
SGTC_1159 4092-0538 61.2 µM 1.35068896073234 0.239236940953582 no 858 0.0883975450023908 554 717301
SGTC_336 4111-0029 111 µM 1.34915181539889 0.239504630495716 no 859 0.0886441040025329 446 3131175
SGTC_2243 6634756 200 µM 1.34487271482699 0.240250684403267 no 860 0.089333171469763 467 885676
SGTC_3164 9100705 49.47 µM 1.34434129166517 0.240343425446964 no 861 0.0894190244325964 441 17174235
SGTC_1600 coumarin 106 71.1 µM 1.34427511794289 0.240354975085885 no 862 0.0894297192859635 535 100336 A hepatotoxic, DNA x-linker.
SGTC_2463 5473429 200 µM 1.34279388827946 0.240613580803726 no 863 0.0896693614758305 485 5399405
SGTC_1641 st009299 47.1 µM 1.34041744922294 0.24102879607842 no 864 0.0900548329607997 451 4046054
SGTC_3078 9116413 49.47 µM 1.33885649991078 0.241301739538416 no 865 0.0903086966291786 473 17177322
SGTC_2780 5215298 71.43 µM 1.33848272973567 0.241367120914912 no 866 0.0903695632183355 556 2834131
SGTC_798 1287-0182 476 µM 1.33768057779412 0.241507469032484 no 867 0.0905002924532489 563 1649755
SGTC_2260 7964312 200 µM 1.33343357228221 0.242251282233921 no 868 0.0911947806269881 467 231951
SGTC_1024 4507-0395 26 µM 1.33341171211708 0.242255113994748 no 869 0.0911983654873844 522 4201836
SGTC_359 0081-0058 15.9 µM 1.33283186750182 0.242356764096326 no 870 0.0912934926725434 504 3494159
SGTC_634 1611-4317 11.2 µM 1.33147398872273 0.242594898474461 no 871 0.0915165491171386 564 2843522
SGTC_554 4483-2211 187 µM 1.3311952183527 0.242643802757945 no 872 0.0915623921830229 512 747107
SGTC_1942 st076330 65.2 µM 1.33059803508011 0.242748583719568 no 873 0.091660654697682 516 24208414
SGTC_2684 capsaicin 100 µM 1.33046804780121 0.242771394355326 no 874 0.0916820535859626 489 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1736 st036774 51 µM 1.32750103178929 0.243292372332127 no 875 0.0921714994254444 553 1272247
SGTC_3318 9139014 38.6185 µM 1.3246932653245 0.243785943651349 no 876 0.0926364538951266 494 16643984
SGTC_2048 5246248 200 µM 1.3245497376563 0.24381118858823 no 877 0.0926602680044245 474 677046
SGTC_2799 7812892 81.82 µM 1.32299908605713 0.24408402108129 no 878 0.0929178408829787 563 20205235
SGTC_1409 3909-8004 61.9 µM 1.32078578329495 0.24447373013084 no 879 0.0932864006750129 550 2119279
SGTC_3015 9080845 49.47 µM 1.31928406780473 0.244738336649262 no 880 0.0935370810767598 551 5296973
SGTC_1042 0350-0096 82 µM 1.3175321903332 0.245047217169192 no 881 0.0938301491448999 518 3122515
SGTC_775 4577-0580 57.3 µM 1.31588326528782 0.245338137203712 no 882 0.0941066131955047 531 2006902
SGTC_895 0964-0006 13.7 µM 1.30968712199984 0.246432980917898 no 883 0.0951508509417782 532 6738897
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.30678452740006 0.246946761569883 no 884 0.0956429507388993 521 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3255 9139072 49.47 µM 1.30605011230925 0.247076849264664 no 885 0.0957677582655035 544 17646060
SGTC_1375 2910-0797 186 µM 1.30381118101118 0.247473659576267 no 886 0.096148984713103 535 742508
SGTC_3068 9116768 49.47 µM 1.303472044648 0.247533795082126 no 887 0.0962068271680418 505 41904888
SGTC_3273 9137859 49.47 µM 1.30112623483816 0.247949966693854 no 888 0.0966076245660041 492 2377234
SGTC_1503 4585-0012 61.3 µM 1.30077937765576 0.248011534519671 no 889 0.0966669913860582 503 2922052
SGTC_2690 usnic acid 100 µM 1.30045976641594 0.24806827335788 no 890 0.0967217186064285 624 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_958 1222-0007 33 µM 1.2999134767423 0.248165269211929 no 891 0.0968153127883672 596 7312461
SGTC_103 0844-0104 51.839 µM 1.29536538364247 0.248973585413464 no 892 0.0975971068331173 659 5375804
SGTC_1464 k208-0027 110 µM 1.29450115307237 0.249127340254079 no 893 0.0977461856293377 571 X1464
SGTC_368 fentichlor 4.58 µM 1.29181166903461 0.249606148027931 no 894 0.0982111866331648 462 7329 A pesticide.
SGTC_173 1273-0061 2.693 µM 1.29178350108676 0.249611165341929 no 895 0.0982160653180697 596 2847414 YPL266W DIM1
SGTC_836 0330-0104 1.35 µM 1.28921832070666 0.250068303336 no 896 0.0986610987589884 554 46494820
SGTC_644 1498-1197 63.3 µM 1.28604015189999 0.250635296794416 no 897 0.0992145245559031 598 6741615
SGTC_3297 9117502 71.43 µM 1.28115296265743 0.251508510793283 no 898 0.100069972010335 529 7453720
SGTC_1254 0550-0035 264 µM 1.27962236527226 0.251782319053472 no 899 0.100338990101353 598 15121435
SGTC_2279 7948423 32.93 µM 1.27940771829852 0.251820729787109 no 900 0.100376758653136 515 1247112
SGTC_2761 levamisole 97.89 µM 1.27809266277688 0.252056124394399 no 901 0.100608377855301 557 26879 An alkaline phosphatase inhibitor.
SGTC_2965 9082772 38.63 µM 1.27710443195993 0.252233093829826 no 902 0.100782690197352 596 16459634
SGTC_704 1310-0270 142 µM 1.27673720145628 0.252298873069814 no 903 0.10084752145191 584 5718033
SGTC_2795 7780010 54.55 µM 1.2745377954283 0.252693025355424 no 904 0.101236443407472 528 953673
SGTC_3238 9133470 49.47 µM 1.27381310944304 0.252822966244832 no 905 0.101364829025505 543 3534688
SGTC_2685 mycophenolic acid 18.85 µM 1.27301283260706 0.252966501924231 no 906 0.101506744112352 517 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2304 7443016 91.4 µM 1.27150725748704 0.2532366543458 no 907 0.101774123601735 494 939854
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.27094214989496 0.253338093400494 no 908 0.101874614935525 541 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2330 7979373 200 µM 1.27047083255385 0.25342271306678 no 909 0.101958483058998 570 1863007
SGTC_2318 6029776 164 µM 1.27044261408504 0.253427779843067 no 910 0.101963505961779 581 818325
SGTC_396 dithiazanine 1.25 µM 1.26913160276374 0.253663237585713 no 911 0.102197065255547 533 10578 An antihelmenthic.
SGTC_292 k038-0015 474 µM 1.26801659906321 0.253863582716338 no 912 0.102396011443598 525 46368540
SGTC_144 4161-2749 112.381 µM 1.26786460403549 0.253890899786739 no 913 0.102423153178887 483 797501 YMR168C CEP3
SGTC_3018 9082602 49.47 µM 1.26544009241842 0.254326849867153 no 914 0.102856805416584 600 17332089
SGTC_352 k048-0007 5.11 µM 1.2646207642232 0.254474261471087 no 915 0.103003653002978 639 6811911
SGTC_3229 9132204 49.47 µM 1.26185406630097 0.254972369906179 no 916 0.103500651536482 509 17682924
SGTC_1026 k007-1105 30.6 µM 1.25371078435422 0.256441418490127 no 917 0.104973573335556 668 7066794
SGTC_1784 st039334 36.3 µM 1.25330855800913 0.256514094273787 no 918 0.10504671756227 573 3496984
SGTC_1382 3002-2117 298 µM 1.25318022819904 0.256537283648717 no 919 0.10507006189638 615 1497314
SGTC_846 0335-0850 148 µM 1.25272015953729 0.256620427668873 no 920 0.105153783338312 541 6819598
SGTC_1916 st067606 49.2 µM 1.25269233786273 0.256625456076727 no 921 0.105158847762118 633 19590279
SGTC_3279 9140807 49.47 µM 1.25178750604024 0.25678902069259 no 922 0.105323651973235 569 45595718
SGTC_3213 9129884 49.47 µM 1.25145724811728 0.256848734263173 no 923 0.105383850995808 498 17190742
SGTC_826 1683-5028 118 µM 1.25117508282476 0.25689975798238 no 924 0.10543530346425 568 722377
SGTC_2800 7887935 81.82 µM 1.24903230361573 0.257287407035983 no 925 0.105826629441402 565 2961002
SGTC_684 1140-0066 328 µM 1.24529878386686 0.257963561779503 no 926 0.106510971270365 640 6813534
SGTC_348 k064-0012 10.7 µM 1.24451681788358 0.258105295478335 no 927 0.106654706799026 536 5066323
SGTC_1324 1418-0026 34.4 µM 1.2433699547647 0.258313240904046 no 928 0.106865768327315 606 1372513
SGTC_2420 aureobasidin a 50 nM 1.24194430466126 0.258571856053568 no 929 0.10712855599095 636 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2408 sulbentine 18.36 µM 1.24121815477571 0.258703632293065 no 930 0.10726258495834 586 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3245 9134821 49.47 µM 1.24083610584616 0.258772977623545 no 931 0.107333150079596 591 17014901
SGTC_717 1532-0246 73.2 µM 1.24073002633099 0.258792233719621 no 932 0.107352749090767 599 9561992
SGTC_1361 1608-0041 5.61 µM 1.24041067754386 0.25885020802069 no 933 0.107411766823416 596 X1361
SGTC_636 0kpi-0074 126 µM 1.24024281190998 0.258880684896172 no 934 0.107442798860079 550 616434
SGTC_128 0906-2981 13.371 µM 1.23275750233416 0.260241566285774 no 935 0.108833125564743 531 6740226
SGTC_1608 st001473 40.5 µM 1.23083452563747 0.260591771073418 no 936 0.10919237985379 570 7292267
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.23060484715002 0.260633615409218 no 937 0.10923534573949 621 5282309
SGTC_2480 5767542 37.17 µM 1.22584661265113 0.26150127917032 no 938 0.11012820119118 607 2867358
SGTC_1779 st039427 55 µM 1.2241510910142 0.261810815415639 no 939 0.110447617774972 697 1124498
SGTC_727 3032-0951 202 µM 1.21865387882891 0.262815683219741 no 940 0.111487795054087 560 3652836
SGTC_2650 prasterone 100 µM 1.21789090436167 0.262955307535096 no 941 0.111632716556848 504 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1749 st037932 54.2 µM 1.21744857324663 0.263036271483014 no 942 0.111716795857173 576 594497
SGTC_2823 7987624 58.44 µM 1.21534341094933 0.263421773305847 no 943 0.112117570705676 633 2239440
SGTC_715 0868-0130 184 µM 1.21521823703952 0.263444704501368 no 944 0.112141433291254 573 2876258
SGTC_2062 5245942 200 µM 1.21504880533746 0.263475745112396 no 945 0.112173738763591 636 1376160
SGTC_201 4262-0159 12.803 µM 1.21484114522963 0.263513791876468 no 946 0.112213342301973 529 1341029
SGTC_3217 9129673 49.47 µM 1.21277848662023 0.263891857211498 no 947 0.112607261352575 593 17248312
SGTC_1626 st003712 1.76 µM 1.21085375351908 0.264244891363377 no 948 0.112975729759258 577 24207035
SGTC_2882 9058044 58.44 µM 1.21067463038262 0.264277758321106 no 949 0.113010064578781 577 18076804
SGTC_941 3237-0776 460 µM 1.20791799689963 0.264783830046323 no 950 0.113539403170875 581 760008
SGTC_1297 1068-0111 14.1 µM 1.20682061224757 0.264985428506299 no 951 0.113750618094354 586 767057
SGTC_1177 0983-0204 23.6 µM 1.19590819448613 0.266994362786887 no 952 0.115866193502936 676 766818
SGTC_3199 9111318 49.47 µM 1.19363111889321 0.267414531581796 no 953 0.116311147792523 627 8548020
SGTC_1590 st077108 57.8 µM 1.18900208741044 0.268269713069878 no 954 0.117219422758604 603 5489485
SGTC_440 fluspirilene 35.1 µM 1.18781469328107 0.268489297419864 no 955 0.117453212136978 631 3396 An atypical antipsychotic.
SGTC_3112 9123419 49.47 µM 1.18487261131262 0.269033764565239 no 956 0.118033908927415 655 17015854
SGTC_948 3448-0295 75.3 µM 1.18244770884569 0.269482937735658 no 957 0.118514051199671 680 678569
SGTC_963 1269-2853 151 µM 1.18110205417281 0.269732360125302 no 958 0.118781092006338 594 3668223
SGTC_366 0181-0206 4.31 µM 1.17812718995864 0.270284172928429 no 959 0.119372951909907 665 274874
SGTC_3133 9127736 49.47 µM 1.17384932952947 0.271078668914881 no 960 0.120227690627799 660 27243420
SGTC_2645 abamectin 100 µM 1.17353957385531 0.271136242781009 no 961 0.120289748413239 621 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2079 5212404 121 µM 1.17285983916899 0.27126260551119 no 962 0.120426008471541 630 758462
SGTC_2143 5623677 140.463 µM 1.17230746777977 0.271365313010027 no 963 0.120536817237458 598 5375313
SGTC_215 1287-0124 461.5 µM 1.17186768353285 0.271447099998322 no 964 0.120625091720542 583 5560863
SGTC_936 3005-4620 401 µM 1.17123596744558 0.271564602171328 no 965 0.120751970824698 717 777207
SGTC_689 0833-0039 98 µM 1.1696699384689 0.271856000134832 no 966 0.121066910094848 675 5374726
SGTC_1945 st075991 56.6 µM 1.16928298413385 0.271928026407759 no 967 0.121144818244254 614 1084980
SGTC_327 1273-0057 3.96 µM 1.1666964987062 0.272409709042225 no 968 0.121666478646472 611 3108138
SGTC_2451 5856223 45.7 µM 1.1656849214991 0.272598210849777 no 969 0.121870929389074 633 2179896
SGTC_2464 5717415 7.67 µM 1.16493596963528 0.27273781558327 no 970 0.122022456108019 650 5285744
SGTC_426 0988-0037 14.6 µM 1.1639978173123 0.272912737342631 no 971 0.122212448158916 706 5383008
SGTC_1821 st053465 65.6 µM 1.16399080880569 0.272914044312364 no 972 0.122213868283678 610 675086
SGTC_2058 5236698 133 µM 1.16099919059002 0.273472214539179 no 973 0.122821114304399 630 766665
SGTC_2846 9008642 19.48 µM 1.15975538963785 0.273704446674481 no 974 0.123074205787241 598 2992898
SGTC_580 1123-0028 41 µM 1.15851235112237 0.273936633877171 no 975 0.123327507140907 730 1677248 YPR107C YTH1
SGTC_2722 naftopidil 47.16 µM 1.15821336118595 0.273992496739045 no 976 0.123388488554965 680 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2141 5621638 7.665 µM 1.15444286472903 0.274697453829389 no 977 0.124159325042022 649 2856238
SGTC_2004 4023728 41.89 µM 1.15164831848052 0.275220517258202 no 978 0.124732808753531 671 360084 YDR527W RBA50
SGTC_1068 loratadine 26.9 µM 1.14893928410946 0.275728042789746 no 979 0.125290508752029 634 3957 A H1 histamine antagonist.
SGTC_997 3996-0078 137 µM 1.14817044691672 0.275872164773236 no 980 0.125449103400964 678 735687
SGTC_2750 bromebric acid 70.15 µM 1.14784891582428 0.275932448193348 no 981 0.12551546991373 731 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2898 9056270 58.44 µM 1.14687631841631 0.276114838516584 no 982 0.125716370707844 585 19154699
SGTC_1117 retinoic acid 1.10837 µM 1.14540505451358 0.276390855752322 no 983 0.126020702755282 732 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3236 9132701 49.47 µM 1.14536699215453 0.276397998256601 no 984 0.126028582793375 651 24282524
SGTC_1451 4152-0210 104 µM 1.13828015725114 0.277729437230369 no 985 0.127501758460507 689 659563
SGTC_1713 st033146 12.748 µM 1.13790415561229 0.277800165940286 no 986 0.127580252923903 681 674619
SGTC_1755 st041960 45.185 µM 1.13234401168578 0.278847095819763 no 987 0.128744916756631 666 2257073
SGTC_2306 7482397 179.52 µM 1.1305761662019 0.27918036856032 no 988 0.129116761860543 678 891448
SGTC_119 0121-0043 24.815 µM 1.130238379838 0.279244069786353 no 989 0.129187895816484 841 1092378
SGTC_940 3232-1287 54.8 µM 1.12993719101263 0.279300875245584 no 990 0.129251345655777 699 1585493 YIL048W NEO1
SGTC_136 0097-0015 404.482 µM 1.12806705342774 0.279653716552822 no 991 0.129645800982166 729 4861337
SGTC_1735 st034310 56.75 µM 1.12799489402941 0.279667335294657 no 992 0.129661037759482 677 871153
SGTC_1248 0469-0687 58.6 µM 1.1279744585705 0.27967119216522 no 993 0.129665353022709 695 4017482
SGTC_2299 7976368 114.88 µM 1.12676434460581 0.279899628102362 no 994 0.129921064666801 664 2979718
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.12333066219874 0.280548304270138 no 995 0.130648542993575 666 140250 A respiratory chain inhibitor.
SGTC_2956 9076196 2.52 µM 1.11898073727398 0.281371116098696 no 996 0.131574178451456 679 16423868
SGTC_1302 1159-0335 255 µM 1.11813207479297 0.281531780874419 no 997 0.131755294651774 670 649284
SGTC_2356 9061756 188.97 µM 1.1144425616746 0.282230776018446 no 998 0.132544686392178 663 20104043
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.11416778064997 0.282282867941824 no 999 0.132603607415928 707 688667
SGTC_1047 2043-3044 82 µM 1.11323117879148 0.282460460049982 no 1000 0.132804577586325 701 669592
SGTC_707 0865-0008 204 µM 1.11307434984971 0.28249020214383 no 1001 0.132838249450483 717 723043
SGTC_570 0987-0065 62.6 µM 1.11188689246191 0.28271544839335 no 1002 0.133093392550894 593 3104428
SGTC_2263 7948595 193.29 µM 1.11111290094951 0.282862311628354 no 1003 0.133259877743158 636 2971371
SGTC_2373 9071805 200 µM 1.11030654850797 0.283015354240015 no 1004 0.13343347610159 708 10149009
SGTC_2876 9059903 25.97 µM 1.10798801476664 0.283455624400082 no 1005 0.133933496017268 755 6916095
SGTC_2959 9079155 11 µM 1.10089769027091 0.284804050976859 no 1006 0.135470593716674 637 16189457
SGTC_658 3253-0951 102 µM 1.10074817832529 0.284832517841246 no 1007 0.135503135737219 811 1184878
SGTC_1170 0310-0127 64.8 µM 1.10013952075588 0.28494841939801 no 1008 0.135635668378349 728 774975
SGTC_2358 9037157 4 µM 1.09521230587199 0.28588749470584 no 1009 0.136711817848494 713 2388925
SGTC_1085 doxorubicin 7.67 µM 1.09291233445093 0.286326348206712 no 1010 0.137216146078557 763 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_685 1278-0033 54.9 µM 1.0890257991124 0.287068657160961 no 1011 0.138071254453684 733 3590572
SGTC_862 0452-0056 10.2 µM 1.08572808526383 0.287699217936679 no 1012 0.138799655639959 697 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_282 k297-0036 65.7 µM 1.08525862460217 0.2877890374002 no 1013 0.138903562826547 674 5061378
SGTC_2831 7999036 19.48 µM 1.08013109416116 0.288770922491521 no 1014 0.14004190358139 762 2988270
SGTC_2727 riluzole 51.77 µM 1.0794718477593 0.288897277761861 no 1015 0.14018871857228 663 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_56 0957-0365 83.25 µM 1.07731968905787 0.289309954913977 no 1016 0.140668734576832 733 6752360
SGTC_1222 0366-0074 1.18 µM 1.0749426087195 0.28976608257247 no 1017 0.141200211960092 782 286520
SGTC_1640 st009078 66.4 µM 1.07359875679061 0.290024097713747 no 1018 0.141501277527072 660 690618
SGTC_446 go6976 132 µM 1.0685477807017 0.290994830326332 no 1019 0.142636744685181 697 3501 A protein kinase C inhibitor.
SGTC_2267 7931562 200 µM 1.06720125647121 0.291253871013948 no 1020 0.142940482655789 664 934880
SGTC_2748 diazoxide 86.69 µM 1.06532513734871 0.291614973096887 no 1021 0.14336441060514 675 3019 A potassium channel activatior.
SGTC_2456 5770359 74.46 µM 1.06443431253766 0.291786505780531 no 1022 0.14356599837006 770 3118787
SGTC_350 k064-0020 19.8 µM 1.06188648800934 0.292277361205361 no 1023 0.144143609947585 786 2790705
SGTC_1849 st056239 19.2 µM 1.06159284669465 0.292333957842321 no 1024 0.144210281269963 737 5393181
SGTC_2745 rifampicin 24.3 µM 1.06129233220997 0.292391884495363 no 1025 0.144278534669074 606 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_458 nppb 133 µM 1.05815526624371 0.292996898301858 no 1026 0.144992330869726 719 4549 A chloride channel blocker.
SGTC_953 1188-0045 9.7 µM 1.05672007170093 0.293273883099226 no 1027 0.145319680875964 755 6144426
SGTC_813 k007-0158 173 µM 1.05659977736264 0.293297104768758 no 1028 0.145347141082658 823 6523916
SGTC_2108 5365811 200 µM 1.049852589387 0.294600946915538 no 1029 0.146892946065724 767 780283
SGTC_76 0433-0009 400.328 µM 1.04913483736812 0.294739804186895 no 1030 0.147058032152116 664 2841569
SGTC_1840 st055363 71 µM 1.04674174451468 0.295202993066805 no 1031 0.147609352508184 705 676033
SGTC_2902 5787006 60.46 µM 1.04452656432799 0.295632044943029 no 1032 0.148120917746807 742 591003
SGTC_1500 4488-1866 171 µM 1.04369779793711 0.295792639969684 no 1033 0.148312614490824 809 2900003
SGTC_53 0973-0023 39.979 µM 1.04230355258699 0.296062901626783 no 1034 0.14863548290373 740 674768
SGTC_2074 5212007 75.395 µM 1.04199591410747 0.296122549779575 no 1035 0.14870678664224 706 758611
SGTC_105 0111-0055 734.78 µM 1.03855524764032 0.296790037410426 no 1036 0.149505814121547 674 5179370
SGTC_1215 3852-0577 11.2 µM 1.0330566876977 0.297858182745003 no 1037 0.150788685444385 840 2884876
SGTC_258 haloperidol 50.781 µM 1.03170971757088 0.298120111027572 no 1038 0.151104061871417 746 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1176 0848-0131 83.3 µM 1.02826628722415 0.29879018800566 no 1039 0.151912292380736 821 6769040
SGTC_3280 9140961 49.47 µM 1.027724025551 0.298895772185534 no 1040 0.152039831498489 739 4901226
SGTC_147 4466-0538 29.23 µM 1.02746581070909 0.298946055349004 no 1041 0.152100588223024 787 6742687 YHR072W ERG7
SGTC_1138 3761-0006 1.03 µM 1.02511103821748 0.299404786375882 no 1042 0.152655398886835 780 12061087
SGTC_966 1300-0360 30.2 µM 1.02476249303231 0.299472713248391 no 1043 0.152737633940786 766 70588
SGTC_3253 9135987 49.47 µM 1.01875531046003 0.300644530225851 no 1044 0.15415957339839 731 4182430
SGTC_1659 st012954 42.1 µM 1.01865986941738 0.300663164537746 no 1045 0.154182235354864 761 24207262
SGTC_1370 2001-0092 44.6 µM 1.01712409846921 0.300963086596156 no 1046 0.154547198802521 893 790957
SGTC_764 1951-2361 146 µM 1.01429482100625 0.301515971526729 no 1047 0.155221047275874 763 5438930
SGTC_1881 5652484 16 µM 1.01298784645645 0.301771528956441 no 1048 0.155532983055857 759 2255129
SGTC_2256 7954252 200 µM 1.01273725676806 0.30182053878071 no 1049 0.155592838541632 686 2972920
SGTC_758 0868-0029 16 µM 1.00926651464194 0.302499707060637 no 1050 0.156423417327987 807 762687
SGTC_2747 doxorubicin 7.63 µM 1.00887014783496 0.302577313227454 no 1051 0.156518456779182 611 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_579 4491-1009 110 µM 1.00748495455906 0.302848595549786 no 1052 0.156850892140456 999 1271041
SGTC_338 4055-0136 114 µM 1.00470172280253 0.303394004800157 no 1053 0.157520249174886 779 2900563
SGTC_1178 0988-0033 191 µM 1.00258597982211 0.303808904621775 no 1054 0.15803033158381 799 5392207
SGTC_2907 7721985 69.9 µM 0.999568741046245 0.304401026341422 no 1055 0.158759628474328 779 3267881
SGTC_454 lyso-paf C-16 6.67 µM 0.999045890060767 0.304503686075405 no 1056 0.158886230740801 816 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_529 4076-0302 30.3 µM 0.998517724567651 0.304607404930624 no 1057 0.159014187013496 784 5816522
SGTC_1501 4491-0275 38.4 µM 0.998443852016925 0.304621912955179 no 1058 0.159032089163998 821 5104718
SGTC_1797 st048695 56.8 µM 0.996209362334689 0.305060895417503 no 1059 0.15957421570023 802 592262 YIL048W NEO1
SGTC_2687 chenodiol 100 µM 0.994481001044932 0.305400637653998 no 1060 0.159994375223936 748 5702181 A cholesterol synthesis inhibitor.
SGTC_776 4476-4378 112 µM 0.993269383817958 0.305638904025515 no 1061 0.160289346745439 772 2892008
SGTC_1116 jasmonic acid 1.58368 µM 0.991844424958602 0.305919229693561 no 1062 0.160636711392051 820 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1529 apigenin 74 µM 0.991544543976352 0.305978238404769 no 1063 0.160709876464999 812 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.990987412083818 0.306087880715534 no 1064 0.160845863472729 777 364106
SGTC_81 0411-0046 9.971 µM 0.990203852100506 0.306242112967572 no 1065 0.161037245051586 741 12925265
SGTC_3306 9127676 59.7925 µM 0.989459052115428 0.306388747722821 no 1066 0.161219297353777 777 41905287
SGTC_877 0771-0151 33.1 µM 0.985982610430043 0.30707359260739 no 1067 0.162070823137239 832 6166523
SGTC_2971 9092186 9.93 µM 0.984085608542227 0.307447578504874 no 1068 0.162536711168508 743 25236400
SGTC_2327 6189656 200 µM 0.981055753711814 0.308045316843961 no 1069 0.16328262409172 817 5349088
SGTC_2809 7964133 12.99 µM 0.965016595299556 0.311218026167755 no 1070 0.167268249860714 828 1253665
SGTC_3353 9151644 39.2805 µM 0.962537289940209 0.311709720144105 no 1071 0.167889890486615 835 4909158
SGTC_382 3229-0966 23.2 µM 0.962164972589997 0.311783586868064 no 1072 0.167983370551054 880 5722370
SGTC_3103 9120822 49.47 µM 0.961397746326222 0.311935826296902 no 1073 0.168176108507847 882 17141819
SGTC_2008 4012253 172 µM 0.96066254724014 0.312081740777217 no 1074 0.168360934226831 856 603940
SGTC_3158 9100007 49.47 µM 0.95967196928343 0.312278386764187 no 1075 0.168610167537681 768 19297233
SGTC_1086 cerivastatin 2.18 µM 0.959258666137201 0.312360450040826 no 1076 0.168714226319808 825 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2931 9014674 55.67 µM 0.959251921380767 0.312361789321024 no 1077 0.168715924812976 808 2996810
SGTC_2990 9074105 71.4286 µM 0.957036156045104 0.31280189935734 no 1078 0.169274502996641 818 6502001
SGTC_492 tmb-8 126 µM 0.952252985609665 0.313752874094341 no 1079 0.170484347511973 704 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1131 3454-3128 32.3 µM 0.950082265600513 0.314184858801601 no 1080 0.171035226804342 897 710982
SGTC_2522 biochanin a 4.94 µM 0.947938834541809 0.314611662778951 no 1081 0.171580296712487 836 5280373 A possible chelator.
SGTC_183 3914-0051 30.55 µM 0.942864173682167 0.315623125887159 no 1082 0.172875190983541 875 1596232
SGTC_460 trequinsin 123 µM 0.939211964823827 0.316351927203014 no 1083 0.173810963594076 933 5537 A vasodilator.
SGTC_853 0419-0306 21 µM 0.935961761995635 0.317001108383796 no 1084 0.174646437848008 789 762713
SGTC_158 k038-0087 26.446 µM 0.931464508620314 0.317900299358433 no 1085 0.175806667659258 926 X158
SGTC_926 2268-1401 59.4 µM 0.93064705998156 0.318063857468648 no 1086 0.176018081406306 871 2931578
SGTC_2262 9014885 67.46 µM 0.929735974165665 0.318246192666994 no 1087 0.176253901789103 831 6457424
SGTC_2948 9070189 9.45 µM 0.929180147623384 0.318357451621452 no 1088 0.176397866987537 799 6473636 YDL196W YDL196W
SGTC_2199 6590217 200 µM 0.928931053508845 0.318407317729614 no 1089 0.176462409241341 815 703109
SGTC_272 doxorubicin 8.13 µM 0.928691685106332 0.318455239949193 no 1090 0.176524445559161 917 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1763 st044482 94.5 µM 0.924056576540438 0.319383799665456 no 1091 0.177728430027205 896 88505
SGTC_1848 st056003 16.4 µM 0.92391154400183 0.319412872621093 no 1092 0.177766186099426 958 146492
SGTC_2219 9098279 200 µM 0.919507265539152 0.320296274241305 no 1093 0.178915153559355 881 902349
SGTC_3247 9135149 49.47 µM 0.918030829658866 0.320592643283932 no 1094 0.179301362857094 845 8934436 YOR116C RPO31
SGTC_2549 cedrol 20.94 µM 0.915413365136698 0.321118335285065 no 1095 0.179987332317148 871 6708665 A sedative which affects the nervous system.
SGTC_3188 9110789 49.47 µM 0.914179346235977 0.321366300327528 no 1096 0.180311307459344 879 849217
SGTC_1439 4092-1168 46 µM 0.911731663208821 0.321858375866324 no 1097 0.1809549958228 912 2886240
SGTC_2621 lithochol-11-enic acid 100 µM 0.906245681536625 0.322962397105095 no 1098 0.182402914452393 929 6708711
SGTC_2403 6032726 181.2 µM 0.902869720319215 0.32364256621101 no 1099 0.183297521376836 875 2881040
SGTC_3313 9133968 57.047 µM 0.900899869786624 0.324039712806258 no 1100 0.183820780235846 946 1494643
SGTC_310 1273-0058 1.06 µM 0.900241511075714 0.32417249087948 no 1101 0.183995869795995 1014 2734232
SGTC_3130 9127414 49.47 µM 0.900163213894548 0.324188283377757 no 1102 0.184016699726562 901 1494646
SGTC_1559 coumarin 343 70.1 µM 0.899892433173998 0.324242902138352 no 1103 0.184088748677974 878 108770 A hepatotoxic, DNA x-linker.
SGTC_1043 0916-0009 19.3 µM 0.898375578660199 0.324548934429344 no 1104 0.184492675827599 1016 3101130
SGTC_2353 9059630 146.67 µM 0.896786273662639 0.324869711074023 no 1105 0.184916486902572 952 4779114
SGTC_1426 4048-4480 71.7 µM 0.893998639034921 0.325432665661032 no 1106 0.185661309666043 932 14224343
SGTC_2027 5150920 200 µM 0.889484343319035 0.32634515919877 no 1107 0.18687141696976 919 786715
SGTC_2478 5763493 32.33 µM 0.885690231059878 0.327112884009389 no 1108 0.187892236946401 941 1365576 YLR208W SEC13
SGTC_2910 7948405 25.97 µM 0.885037920219981 0.327244950580694 no 1109 0.188068089852778 899 2971328
SGTC_1363 1636-0063 10.4 µM 0.884222529158885 0.327410064719449 no 1110 0.188288049469969 962 6072185
SGTC_2492 derrusnin 100 µM 0.879627476546194 0.328341179080592 no 1111 0.189530574497544 857 1715307 Part of coumarin class of compounds.
SGTC_1139 k015-0024 46.9 µM 0.879033599570916 0.328461596812405 no 1112 0.18969152913196 963 2766652
SGTC_465 cgp-37157 41 µM 0.876618506873136 0.328951477645088 no 1113 0.190346941803875 836 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2467 5474540 200 µM 0.876434228836916 0.328988868944599 no 1114 0.190397008593834 951 5413519
SGTC_718 1130-0073 349 µM 0.87469373217506 0.329342112230031 no 1115 0.190870285709277 945 6740020
SGTC_1289 0976-0073 69.1 µM 0.871773886761604 0.329935052894882 no 1116 0.191665871504544 967 3391136
SGTC_2172 5754775 163.918 µM 0.87157628947366 0.32997519495616 no 1117 0.191719785160173 857 2263357
SGTC_774 k060-0086 136 µM 0.865471339873931 0.331216383522157 no 1118 0.193390069923608 1020 5911235
SGTC_1747 st037496 66.6 µM 0.864392689607399 0.331435875750259 no 1119 0.193686103696326 954 723305
SGTC_118 0083-0097 135.343 µM 0.864154925253203 0.331484265700072 no 1120 0.193751394874734 1097 5207356
SGTC_1882 5615643 20 µM 0.862854817508443 0.331748914166866 no 1121 0.194108647633151 925 2253075
SGTC_1964 st076914 61 µM 0.859940055480516 0.332342544913173 no 1122 0.194911043481061 1008 24208661
SGTC_3013 9080133 71.4286 µM 0.858137225879401 0.332709926323542 no 1123 0.195408346953569 1008 17050193
SGTC_1448 4255-0083 152 µM 0.857774448875789 0.332783872614633 no 1124 0.195508510637415 1019 5399660
SGTC_1066 ketoconazole 628 nM 0.857260157359581 0.332888713863452 no 1125 0.195650561297927 1009 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1850 st056238 17 µM 0.85709828346581 0.332921715480704 no 1126 0.195695284881407 1049 5393177
SGTC_2379 9035213 200 µM 0.842353391728573 0.335933192049468 no 1127 0.199795086755249 1026 646551
SGTC_2281 7943571 200 µM 0.842203289514097 0.335963903357454 no 1128 0.19983708641667 1064 1244024
SGTC_3331 9141060 1.957 µM 0.841880436516223 0.336029963641283 no 1129 0.199927440961719 943 4906567 YPR165W RHO1
SGTC_1093 fluphenazine 7.97 µM 0.841313286960702 0.3361460227147 no 1130 0.200086224496684 1006 6602611 An atypical antipsychotic.
SGTC_497 capsazepine 133 µM 0.838533775959363 0.336715035716863 no 1131 0.200865493180519 995 2733484 A calcium channel blocker.
SGTC_3230 9131665 49.47 µM 0.838321585230116 0.336758490136867 no 1132 0.200925058082932 934 15943720
SGTC_2050 5263056 171 µM 0.835472459332322 0.337342171919466 no 1133 0.20172587357712 1027 763468 YGL055W OLE1
SGTC_2949 9072542 2.23 µM 0.828137447654712 0.338846647106501 no 1134 0.203796331992386 1033 16457352
SGTC_1391 3442-0225 151 µM 0.826199614272975 0.33924454461271 no 1135 0.204345433512412 956 5227075
SGTC_750 4073-0104 132 µM 0.824149954544647 0.33966559870939 no 1136 0.204927179421863 855 22330957
SGTC_1429 4049-0205 9.46 µM 0.817514966471906 0.341029970509874 no 1137 0.206817099940258 1050 22774478
SGTC_831 k061-1017 217 µM 0.816435953817616 0.341252048241542 no 1138 0.207125420090638 1114 1240153
SGTC_1539 benzyladenosine 56 µM 0.815598511735808 0.341424444867214 no 1139 0.207364900472403 1026 92208 A nucleotide analog.
SGTC_3064 1327-0027 10 µM 0.812904424008311 0.341979276664379 no 1140 0.208136428931312 895 16000455 YPR107C YTH1
SGTC_1257 0669-0121 16 µM 0.81226556999819 0.342110895079592 no 1141 0.208319631089826 1107 4307855
SGTC_1392 3455-1037 33.9 µM 0.810962676394057 0.342379380160815 no 1142 0.208693552491516 1016 981132
SGTC_244 nsc-207895 1.295 µM 0.810167148193627 0.342543352498001 no 1143 0.208922057931249 900 42640
SGTC_622 1348-1566 26.3 µM 0.804547641028412 0.343702475352554 no 1144 0.210540383466369 1086 7340407
SGTC_3119 9125183 49.47 µM 0.801567451558199 0.344317789841063 no 1145 0.211401605872202 903 22695334
SGTC_2622 2-methoxyxanthone 59.94 µM 0.801067253665668 0.344421105274132 no 1146 0.211546356219892 1054 71034 A hepatoprotective.
SGTC_2916 7875993 68.79 µM 0.799179257039343 0.344811173861956 no 1147 0.212093238933162 1018 1299250
SGTC_2788 5282734 71.43 µM 0.797420993582428 0.345174587410939 no 1148 0.212603285385089 1071 743706
SGTC_1634 st006576 41 µM 0.794885484719872 0.345698900380573 no 1149 0.213340059247049 1048 3915356
SGTC_1032 k061-1018 98.7 µM 0.794550727434746 0.345768146340369 no 1150 0.21343744488819 1129 4005393
SGTC_3256 9138902 49.47 µM 0.79379262638005 0.345924981819399 no 1151 0.213658082993342 1076 17228773
SGTC_512 prima-1 270 µM 0.792958450160609 0.346097586232025 no 1152 0.213901015525178 1065 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1729 st035615 45.989 µM 0.791285382270321 0.346443867117234 no 1153 0.214388738289442 990 17385451
SGTC_2150 5556613 200 µM 0.790871994889507 0.346529447181415 no 1154 0.214509346075085 1062 743190
SGTC_2766 oltipraz 83.91 µM 0.789197601385174 0.34687616267626 no 1155 0.214998261844269 1015 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_365 0121-0052 13.6 µM 0.788216395377391 0.347079399941629 no 1156 0.215285070280191 1061 3101739
SGTC_908 3448-7491 47.7 µM 0.784455689652602 0.347858762158975 no 1157 0.21638638612621 1099 1203031
SGTC_361 000s-0510 1.45 µM 0.784444112377266 0.34786116240851 no 1158 0.216389781537152 1038 660
SGTC_2636 apigenin dimethyl ether 100 µM 0.784329355567317 0.34788495460391 no 1159 0.216423439355945 1034 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2205 7238770 200 µM 0.784111057101148 0.347930215442837 no 1160 0.216487473986363 1079 279867
SGTC_1504 k297-0033 30 µM 0.782915013198112 0.348178235245619 no 1161 0.216838510325257 975 4388117
SGTC_709 3807-1509 243 µM 0.782890102631064 0.348183401561109 no 1162 0.216845825020356 1072 1886677 YPL242C IQG1
SGTC_1646 st011709 75.6 µM 0.781615606445958 0.348447762681543 no 1163 0.217220256157606 1043 5757843
SGTC_1250 0485-0349 40.2 µM 0.77906718095362 0.348976588042481 no 1164 0.217970070782428 1051 6842794 YDL195W SEC31
SGTC_46 0329-0187a 2.197 µM 0.77234142297223 0.35037366124284 no 1165 0.219956118841349 1109 46494817
SGTC_2984 9022109 38.96 µM 0.77059450633663 0.350736862788249 no 1166 0.22047365924432 1061 6459207
SGTC_1793 st048256 72.231 µM 0.76939878460623 0.350985544057745 no 1167 0.22082830494543 1050 672022
SGTC_192 3455-0609 60.9 µM 0.76747065810356 0.35138668227989 no 1168 0.22140086608819 1107 3769639
SGTC_2838 9002687 71.43 µM 0.762750359160528 0.352369417807114 no 1169 0.222806145523921 1033 6457060
SGTC_905 2-aminofluorene 215 µM 0.761338389323394 0.352663572706204 no 1170 0.223227488290083 1167 1539 An established DNA mutagen. YPR165W RHO1
SGTC_973 1325-0077 65.9 µM 0.761125893306485 0.352707849517103 no 1171 0.223290937993746 1151 2835149
SGTC_2071 5230951 39.92 µM 0.75982437189462 0.352979085022704 no 1172 0.223679786335002 1164 1799272
SGTC_2703 st077852 53.4 µM 0.757780744403522 0.353405125290166 no 1173 0.224291125816762 1063 6281836
SGTC_3206 9114350 49.47 µM 0.757745263822106 0.353412523642306 no 1174 0.224301748000567 1018 17087243
SGTC_423 5-fluorouracil 457 µM 0.757525460016499 0.353458358002541 no 1175 0.224367559273899 1068 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1855 st056195 39.6 µM 0.756143376228347 0.3537466042553 no 1176 0.224781618861654 1066 4028379
SGTC_2860 9025725 38.96 µM 0.7547457162985 0.354038184348205 no 1177 0.225200785203781 1069 40546248
SGTC_873 0591-4978 488 µM 0.753598535406046 0.35427757343794 no 1178 0.22554516202189 1159 3305145
SGTC_495 decylubiquinone 155 µM 0.752657352925091 0.354474018622062 no 1179 0.225827921785089 1084 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1122 capsaicin 818.572 nM 0.752322292824249 0.354543962275801 no 1180 0.22592863237118 1109 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1140 3229-1848 2.98 µM 0.747765262450787 0.355495726562145 no 1181 0.227300879219335 1124 2849525
SGTC_168 3970-0862 530.542 µM 0.744315171389555 0.356216899874231 no 1182 0.228342912486931 1160 3135186
SGTC_719 2810-4230 27.3 µM 0.742647650595392 0.356565646754977 no 1183 0.228847515677275 1103 721079
SGTC_1387 3342-1166 1.8 µM 0.740011362077682 0.357117247282995 no 1184 0.229646550046672 1079 3418228
SGTC_983 1491-0821 12.2 µM 0.732739098413872 0.358640396058884 no 1185 0.2318587861863 1109 46495113
SGTC_2988 9073640 71.4286 µM 0.730198461113018 0.359173055028525 no 1186 0.232634441538877 1140 9102229
SGTC_1702 st027038 51 µM 0.728196049833387 0.35959306491633 no 1187 0.233246791801304 1169 5521182
SGTC_257 daunorubicin 18.5 µM 0.726954096003551 0.359853652571059 no 1188 0.233627038321956 1166 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1412 3909-8563 178 µM 0.723258658447345 0.360629416927479 no 1189 0.234760493371292 1205 23767530
SGTC_2180 6301957 200 µM 0.72120947382359 0.361059839383357 no 1190 0.235390321901744 1139 845462
SGTC_1490 4089-0339 670 nM 0.719532470026997 0.361412217827475 no 1191 0.235906451693141 1122 742542
SGTC_1645 Cervolide 78 µM 0.71947495312846 0.361424305585372 no 1192 0.235924164668878 1108 23173 A fragrance.
SGTC_2879 9041815 71.43 µM 0.719362768281109 0.361447882763578 no 1193 0.235958715363388 1112 4942971
SGTC_861 0443-0273 110 µM 0.715007922491435 0.362363518938778 no 1194 0.237302073932363 1167 6149169
SGTC_2285 7945142 200 µM 0.713915735380891 0.36259328255971 no 1195 0.237639643318669 1175 2970608
SGTC_1008 4106-0037 6 µM 0.710882485301712 0.363231647350158 no 1196 0.238578530185015 1150 2905394
SGTC_3220 9131269 49.47 µM 0.7107175050447 0.363266379301295 no 1197 0.238629654947159 1202 17722206
SGTC_2208 7283366 200 µM 0.709946967108912 0.363428609266702 no 1198 0.238868511792874 1186 898663
SGTC_2221 6807166 181.081 µM 0.707539592793808 0.363935618402081 no 1199 0.239615608595249 1137 674925
SGTC_1516 st013856 110 µM 0.706362632636233 0.36418358087082 no 1200 0.2399813263068 1136 5281404 A mutagen and neurotoxin.
SGTC_1874 staurosporine 7.6 µM 0.704279782049052 0.364622536027084 no 1201 0.240629277310717 1192 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1995 st072814 61.1 µM 0.703570259420206 0.364772106584826 no 1202 0.240850218958389 1147 5769371
SGTC_2414 st077232 92.9 µM 0.702943744341396 0.364904195891729 no 1203 0.241045404206039 1132 729801
SGTC_515 4092-1064 102 µM 0.701392792423027 0.365231254840591 no 1204 0.241528959388538 1208 717353
SGTC_1972 st070201 17.4 µM 0.699490373374582 0.365632563739552 no 1205 0.242122813522324 1166 2829099
SGTC_265 mycophenolic acid 32.932 µM 0.698707793797552 0.365797688999458 no 1206 0.242367331125399 1277 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_411 enrofloxacin 100 µM 0.698242684194661 0.365895839485059 no 1207 0.242512718352613 1246 71188 A bacterial gyrase inhibitor.
SGTC_83 0170-0301 39.027 µM 0.698093989808156 0.365927219803879 no 1208 0.242559208251241 1149 3089716
SGTC_1224 0823-0416 294 µM 0.697443703353126 0.366064466161805 no 1209 0.242762579626408 1208 3598164
SGTC_1979 st071809 45.3 µM 0.696353893837982 0.366294514582755 no 1210 0.24310361481926 1228 4976333
SGTC_2301 7769476 200 µM 0.693852981208145 0.366822615018339 no 1211 0.243887206393868 1181 977820
SGTC_3086 9117350 49.47 µM 0.687335697176687 0.368200007399519 no 1212 0.24593560434413 1142 2679265
SGTC_2763 lisinopril 49.32 µM 0.685314276550289 0.368627569020368 no 1213 0.246572812391067 1183 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_193 1273-0060 1.558 µM 0.680109061186129 0.369729299990921 no 1214 0.248217703735898 1111 2847393 YHR072W ERG7
SGTC_1421 4029-0249 71.4 µM 0.6784933913949 0.370071489220376 no 1215 0.248729456287873 1298 2894095
SGTC_2245 6637752 200 µM 0.677646505950284 0.370250895621737 no 1216 0.248997925827249 1190 681890
SGTC_1196 1588-0294 184 µM 0.676147509302526 0.370568516130928 no 1217 0.249473497640968 1210 6144269
SGTC_3154 9100113 49.47 µM 0.676004419030227 0.370598839965354 no 1218 0.249518919697674 1213 25237525
SGTC_1120 ficusin 1.78878 µM 0.675966992816494 0.370606771498856 no 1219 0.249530800864066 1266 6199 A DNA cross-linker.
SGTC_1898 st060199 18.6 µM 0.675353871077455 0.370736714875385 no 1220 0.249725482669806 1248 688866
SGTC_2060 5238662 140 µM 0.674974293665265 0.370817168884981 no 1221 0.249846048601609 1201 790130
SGTC_2881 9058953 51.95 µM 0.6737572348243 0.371075170843239 no 1222 0.250232833717283 1206 17122249
SGTC_2215 7188065 200 µM 0.673439291214888 0.371142580649456 no 1223 0.250333929477911 1243 940217
SGTC_15 0266-0086 27.098 µM 0.671657592900643 0.37152040607921 no 1224 0.250900852192409 1313 1712902 YIL048W NEO1
SGTC_669 0108-0021 26.2 µM 0.669220915822716 0.372037326149558 no 1225 0.251677282953387 1332 17201
SGTC_1714 st033236 13.627 µM 0.667165313028449 0.372473584051943 no 1226 0.25233327244158 1285 2916566
SGTC_1376 2910-0861 41.3 µM 0.665637077961426 0.372798025500505 no 1227 0.252821550450274 1259 1112859
SGTC_630 4356-0227 183 µM 0.663516930456093 0.373248278275946 no 1228 0.253499769968136 1261 779312
SGTC_668 1682-0499 62.6 µM 0.662470824525196 0.373470502165679 no 1229 0.253834763395663 1264 682214
SGTC_390 dec-rvkr-cmk 16.7 µM 0.660993717975475 0.373784355004858 no 1230 0.254308171130333 1294 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_606 k015-0008 38.6 µM 0.656855533650287 0.374664073846926 no 1231 0.255636906120842 1307 1970475
SGTC_2397 5161689 200 µM 0.656320643652034 0.374777831548115 no 1232 0.255808918873246 1323 2259942
SGTC_838 0109-0203 71.4 µM 0.655824087586346 0.374883446336303 no 1233 0.255968658057285 1257 759422
SGTC_1078 idebenone 36.1 µM 0.655115270422049 0.375034224168051 no 1234 0.256196770532531 1267 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1902 st060212 70.5 µM 0.648867177594883 0.376364126805588 no 1235 0.258212115787385 1280 688944
SGTC_3314 9135860 59.4275 µM 0.648498348380883 0.376442677946009 no 1236 0.258331339361229 1262 25252478
SGTC_1151 3909-8316 15.3 µM 0.647849063302401 0.376580971406759 no 1237 0.25854128922504 1277 800431
SGTC_262 fenpropimorph 62.5 µM 0.644776761365754 0.377235566106502 no 1238 0.259535931772243 1226 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1080 nisoldipine 24.4 µM 0.642285079562365 0.377766711257204 no 1239 0.260344050086998 1259 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1993 st073995 70.8 µM 0.64209963284231 0.377806251694876 no 1240 0.260404247150502 1275 3098394
SGTC_2723 salbutamol 83.58 µM 0.639219321842173 0.378420547789734 no 1241 0.261340132082954 1275 9884233 β2-adrenoceptor agonist
SGTC_2324 6149169 200 µM 0.634603557786797 0.379405611736095 no 1242 0.262843503596379 1213 2888231
SGTC_2537 larixol 68.93 µM 0.633300011491596 0.379683947568129 no 1243 0.263268872899718 1273 6708759
SGTC_1509 1326-1131 80 µM 0.631718662882321 0.38002168399946 no 1244 0.263785365357345 1260 768313
SGTC_247 mechlorethamine 29.705 µM 0.630580057756843 0.380264918205043 no 1245 0.264157570773133 1222 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_314 1671-0008 2.74 µM 0.630150834523538 0.380356623195821 no 1246 0.264297951513494 1226 3913060
SGTC_759 3486-0358 89.3 µM 0.629006643631263 0.380601116282273 no 1247 0.264672353391793 1319 875103
SGTC_802 4112-3352 742 µM 0.627825377998152 0.380853581616298 no 1248 0.265059169653133 1391 704594
SGTC_1465 k213-0056 144 µM 0.62757533106612 0.38090702926658 no 1249 0.265141086627454 1247 24048857 YMR208W ERG12
SGTC_467 ro 31-8220 72.8 µM 0.626776483799427 0.381077798471206 no 1250 0.265402880229055 1270 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_656 4090-1979 187 µM 0.624882786624602 0.38148270570634 no 1251 0.266023995312381 1323 22330961
SGTC_2106 5357045 167.29 µM 0.621737188771527 0.382155578862631 no 1252 0.26705734692548 1344 668842
SGTC_2544 sphondin 68.51 µM 0.621035873679974 0.38230564541359 no 1253 0.267288010005626 1341 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2629 bisabolol 100 µM 0.617094657838071 0.383149310237677 no 1254 0.268586146059672 1348 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2545 solidagenone 89.61 µM 0.61678380789349 0.383215875065506 no 1255 0.268688666762625 1193 6708572 An anti ulcer agent
SGTC_996 3970-0799 1.8 µM 0.614437451793446 0.383718430501114 no 1256 0.26946314681849 1413 6615648 YGL040C HEM2
SGTC_10 0279-0212 42.575 µM 0.613271038344069 0.383968332200081 no 1257 0.269848569962553 1322 39851 YBR002C RER2
SGTC_1156 4092-0367 4.88 µM 0.610833629173582 0.384490697800247 no 1258 0.270654863785877 1322 1357585
SGTC_2465 5809242 33.21 µM 0.608280897165675 0.385038003385741 no 1259 0.271500594249489 1331 2731748
SGTC_2626 ethyl orsellinate 100 µM 0.604510798420851 0.385846731106685 no 1260 0.272752046057294 1312 75653 A natural product.
SGTC_2608 thymoquinone 42.66 µM 0.60331629949392 0.386103068011115 no 1261 0.273149145887338 1260 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_376 3970-0862 59.1 µM 0.60165316327536 0.386460056273953 no 1262 0.273702516440285 1343 3135186
SGTC_2798 7813637 45.45 µM 0.599978820942125 0.386819546998999 no 1263 0.274260175178064 1352 956368
SGTC_19 0279-0214 38.434 µM 0.598554642889776 0.38712540250332 no 1264 0.274734955029321 1376 3566274 YBR002C RER2
SGTC_1622 st003707 19.4 µM 0.595511877187635 0.387779099419418 no 1265 0.275750681137253 1382 10140899
SGTC_3063 1327-0034 4 µM 0.595503719850762 0.387780852341015 no 1266 0.275753406671465 1253 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_621 3584-0052 32.1 µM 0.592518319091208 0.388422535296578 no 1267 0.276751778674575 1359 2273927
SGTC_1152 3909-8331 15.9 µM 0.592093844940525 0.388513796678479 no 1268 0.276893874168621 1329 16001939
SGTC_1353 1498-1206 8.11 µM 0.591827266346872 0.388571113870693 no 1269 0.276983131353994 1373 6756808
SGTC_1277 0873-0036 22 µM 0.590432791758674 0.388870980039186 no 1270 0.277450265768843 1427 5965735
SGTC_3104 9120930 49.47 µM 0.589953970699552 0.388973960435723 no 1271 0.277610754592048 1340 17014836
SGTC_1141 3253-0389 52.6 µM 0.58957967989504 0.38905446486628 no 1272 0.277736239068377 1329 5402031
SGTC_2899 9053889 58.44 µM 0.5885530069743 0.389275311509006 no 1273 0.278080582855171 1340 6470052
SGTC_2802 7925815 54.55 µM 0.587805520188506 0.389436125192831 no 1274 0.278331419185429 1345 1262923
SGTC_44 0929-0055 61.211 µM 0.587458268038503 0.389510839174201 no 1275 0.278447985113036 1302 1379590
SGTC_2309 7664088 163.95 µM 0.5838634517484 0.390284531156854 no 1276 0.279656092122999 1377 704922
SGTC_1295 1013-0063 9.78 µM 0.583447667929893 0.390374046064075 no 1277 0.279795988224355 1374 6826038
SGTC_1452 4194-0072 190 µM 0.582320862579377 0.390616667385269 no 1278 0.280175287744252 1460 1343545
SGTC_1207 2099-0101 141 µM 0.581657951939606 0.390759423795094 no 1279 0.280398549710618 1388 5837381
SGTC_2791 5663188 71.43 µM 0.578437491020819 0.391453152457646 no 1280 0.281484394174775 1416 54690634
SGTC_959 1222-0044 107 µM 0.57834225893454 0.391473671941203 no 1281 0.281516534483586 1369 6083612
SGTC_2871 9038510 12.99 µM 0.576869353963319 0.391791074505518 no 1282 0.282013857164778 1466 4945164
SGTC_1126 isoteolin 1.0172 µM 0.573547580023041 0.392507161848274 no 1283 0.283136996484647 1334 133323
SGTC_1488 4013-0813 75.9 µM 0.573436838861052 0.392531041022871 no 1284 0.283174476595446 1354 2910057
SGTC_1612 st002233 45.4 µM 0.572342710929739 0.392766990132469 no 1285 0.283544909747216 1390 1035021
SGTC_417 st075190 100 µM 0.570375266900305 0.393191369293766 no 1286 0.284211600529327 1462 222757
SGTC_561 1550-0330 72.9 µM 0.564930753430733 0.394366415274704 no 1287 0.28606043247409 1344 6812934
SGTC_2334 9017922 200 µM 0.56291100727167 0.394802566196061 no 1288 0.286747742241907 1494 3163164
SGTC_3041 9091929 49.47 µM 0.562489327551924 0.394893641821163 no 1289 0.286891336517242 1428 25236887
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.562315665714515 0.394931151485247 no 1290 0.286950483354959 1419 5393153
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.561189904157771 0.395174331204504 no 1291 0.287334042318436 1377 23665772 A membrane-active detergent.
SGTC_1220 1838-0075 193 µM 0.558803243073841 0.395690017209217 no 1292 0.2881480044592 1360 5529645
SGTC_2011 4012611 177 µM 0.556689874496164 0.39614680540403 no 1293 0.288869668102567 1382 2049887
SGTC_1704 st028805 70.8 µM 0.55592218024782 0.396312771898044 no 1294 0.289132027364054 1395 2876101
SGTC_3172 9105863 49.47 µM 0.554627235350677 0.396592766369102 no 1295 0.289574828090172 1407 2348785
SGTC_1450 4112-4260 37.6 µM 0.553222881588271 0.396896477627868 no 1296 0.290055400274668 1417 1633175
SGTC_2753 fluvastatin 17.09 µM 0.549522035370719 0.397697136839169 no 1297 0.291323623361557 1442 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2357 9067248 200 µM 0.549514260673939 0.397698819310153 no 1298 0.291326290352442 1420 9150235
SGTC_2829 7992743 58.44 µM 0.54753661483274 0.398126850357227 no 1299 0.292005061292812 1458 16462845
SGTC_1685 st024049 53.0905 µM 0.542969558720086 0.399115787230618 no 1300 0.293575380966495 1401 1941139
SGTC_2580 diallyl disulphide 81.36 µM 0.542115817087501 0.399300725991279 no 1301 0.293869361564307 1446 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_848 0368-0089 85.6 µM 0.540930673549757 0.399557490973633 no 1302 0.294277683894694 1385 762535
SGTC_1844 rapamycin 4 nM 0.537195588192639 0.400366992415563 no 1303 0.295566259203815 1426 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2716 st080858 38.6235 µM 0.537127525196927 0.400381747625787 no 1304 0.29558976445572 1402 5296050
SGTC_919 tnp00227 403.569 nM 0.527999716001942 0.40236182300452 no 1305 0.2987497665298 1463 1269246 A methoxyflavone. YNL221C POP1
SGTC_3327 9140648 26.9345 µM 0.527700697222584 0.402426731182455 no 1306 0.298853544625298 1465 8029710
SGTC_1018 4259-0013 28.1 µM 0.527402490632191 0.402491465737312 no 1307 0.298957057150793 1461 6801262
SGTC_1657 st012939 43.4 µM 0.527167623281586 0.402542452520379 no 1308 0.299038595021923 1486 24207257
SGTC_3261 9137475 49.47 µM 0.526585458237196 0.402668840462457 no 1309 0.299240746235809 1409 17027690
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.526446904369483 0.402698921985089 no 1310 0.299288866867008 1431 3256 An antibiotic and ribosome inhibitor.
SGTC_1810 st050138 53 µM 0.526001128373644 0.402795708616143 no 1311 0.299443711489324 1452 3444541
SGTC_2036 5160441 105 µM 0.524679258237863 0.403082747311251 no 1312 0.299903089322392 1488 134534 YIL048W NEO1
SGTC_3024 9090631 49.47 µM 0.521879143778655 0.403690953050626 no 1313 0.300877240244112 1442 25236383
SGTC_226 1,3-diallylurea 8.28947 mM 0.52120375038293 0.403837688459575 no 1314 0.301112420917584 1435 74537 YKL182W FAS1
SGTC_2543 pimpinellin 60.67 µM 0.520572468205035 0.403974852539511 no 1315 0.301332316365724 1393 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1745 st081495 74 µM 0.519766210611056 0.404150052193742 no 1316 0.301613266350442 1447 13842402 YBL026W LSM2
SGTC_266 formosanin C 406 nM 0.514795436718682 0.405230624012794 no 1317 0.303347987237114 1457 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3114 9122766 49.47 µM 0.513454799371916 0.405522182607382 no 1318 0.303816610657816 1403 17176985
SGTC_93 0109-0045 59.227 µM 0.513398615164393 0.405534402559815 no 1319 0.303836257049405 1475 88733
SGTC_2957 9076800 11.52 µM 0.512949483025688 0.405632091207899 no 1320 0.303993329127835 1425 16459615
SGTC_1214 0358-0031 63.7 µM 0.512840915935343 0.405655706014458 no 1321 0.304031303026622 1653 4301366
SGTC_2611 pyromycin 23.93 µM 0.509531371556263 0.406375740940451 no 1322 0.305189907247762 1432 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2765 myclobutanil 7.74 µM 0.508744445747622 0.406546993701443 no 1323 0.305465682082209 1464 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1309 pyrazolanthrone 13.4 µM 0.502062329005388 0.408001889825313 no 1324 0.307811838927606 1573 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1617 st002906 78 µM 0.501582963755558 0.408106310974723 no 1325 0.307980452797622 1463 5150859
SGTC_2415 st077333 57.7 µM 0.500783367204659 0.408280503307476 no 1326 0.30826179632872 1707 2766255
SGTC_943 3253-1379 105 µM 0.498411213215226 0.408797384245913 no 1327 0.309097117462553 1568 668464
SGTC_1997 st073024 93.8 µM 0.497804512978943 0.40892960682208 no 1328 0.309310917368361 1479 686268
SGTC_1223 0764-0573 147 µM 0.496851272984128 0.409137374247037 no 1329 0.309646967592214 1467 1609797
SGTC_3011 9081274 71.4286 µM 0.496601238438079 0.40919187580495 no 1330 0.309735139823092 1473 6625322
SGTC_1552 6-methylflavone 10.6 µM 0.492605653278505 0.410063055396396 no 1331 0.311145626381116 1508 689013
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.491649692753082 0.410271554769282 no 1332 0.311483503824255 1489 17037758
SGTC_1288 0973-0013 65.5 µM 0.489626017954583 0.410713011135783 no 1333 0.31219928101291 1542 4315430
SGTC_1952 st077036 64.1 µM 0.488438849053559 0.410972039854227 no 1334 0.312619515029492 1478 2937007
SGTC_334 1502-1024 68.5 µM 0.488417629017654 0.410976670213387 no 1335 0.312627028715958 1509 3296216
SGTC_2249 haloperidol 116.36 µM 0.488359124246596 0.410989436424857 no 1336 0.312647744753711 1539 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2098 5376439 882.5 nM 0.488224176089006 0.411018883557432 no 1337 0.312695530996257 1593 2844116
SGTC_616 4092-0450 108 µM 0.487301613090299 0.411220210102695 no 1338 0.313022302376686 1539 787165
SGTC_2045 5106652 78.05 µM 0.482147783142361 0.412345334712097 no 1339 0.314850483811156 1559 673349
SGTC_435 c-PAF 6.7 µM 0.48122972146418 0.412545831225301 no 1340 0.315176619653442 1497 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1627 st003713 25.6 µM 0.480398315765337 0.412727422536338 no 1341 0.315472095845631 1505 16195070 YER133W GLC7
SGTC_2183 6420625 130.508 µM 0.480368242711909 0.412733991286621 no 1342 0.315482785826711 1487 2897619
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.475997110002352 0.413689021294115 no 1343 0.317038218406845 1661 1273210
SGTC_3203 9113543 49.47 µM 0.475018197029833 0.413902969986947 no 1344 0.317387001568549 1561 17018012
SGTC_2026 5148700 152 µM 0.473932322065593 0.414140325913532 no 1345 0.317774084670001 1492 79838
SGTC_2265 7929201 200 µM 0.472652758817129 0.414420059433134 no 1346 0.318230467768909 1446 1265108
SGTC_3108 9121785 49.47 µM 0.470018172805644 0.414996159725574 no 1347 0.319171017023874 1616 17140271
SGTC_655 k060-0012 42 µM 0.46812766592219 0.415409666291039 no 1348 0.319846647918599 1487 5994525
SGTC_1294 1000-1494 117 µM 0.466830062058307 0.415693542694407 no 1349 0.320310732966771 1481 712797 YDL207W GLE1
SGTC_1960 st011366 51.8 µM 0.465787427487432 0.415921671432888 no 1350 0.320683832615501 1518 3972846
SGTC_2133 5320837 200 µM 0.463193788011709 0.416489283234081 no 1351 0.321612734255515 1584 2841355
SGTC_3023 9089636 49.47 µM 0.460945861715559 0.416981377483838 no 1352 0.322418723552902 1607 17249241
SGTC_419 nsc-638432 893 µM 0.457553662899997 0.417724210843972 no 1353 0.32363657018758 1538 368090
SGTC_2416 tofa 880 nM 0.457531611274371 0.417729040735361 no 1354 0.323644493229066 1443 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_545 4218-0007 221 µM 0.454970119015345 0.418290159798579 no 1355 0.324565368045508 1540 2840508
SGTC_1200 1643-0193 18.4 µM 0.45411664945802 0.418477157363209 no 1356 0.324872435201307 1554 5403974
SGTC_2394 5221648 200 µM 0.453656653511138 0.41857795140479 no 1357 0.325037985090044 1693 788586
SGTC_104 0074-0074 590.992 µM 0.453193801392876 0.418679376684944 no 1358 0.325204597771384 1525 3943124
SGTC_1084 voriconazole 435 nM 0.450632077017933 0.419240827672424 no 1359 0.326127371901301 1586 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1355 1499-0035 1.68 µM 0.448873093610825 0.419626437911209 no 1360 0.326761603370709 1522 1548538
SGTC_618 k072-0232 33.2 µM 0.448403392884311 0.419729420352504 no 1361 0.326931046790168 1564 5872756 YGL099W LSG1
SGTC_3224 9130643 49.47 µM 0.447256464634694 0.419980908818692 no 1362 0.327344948347273 1619 17644395
SGTC_894 0960-0238 55.9 µM 0.443372542689414 0.420832783605809 no 1363 0.328748146341301 1583 6741907 YDL195W SEC31
SGTC_1253 0550-0034 176 µM 0.443156265319071 0.420880231448149 no 1364 0.328826355089055 1554 5969915
SGTC_729 4092-0585 94.1 µM 0.437170669601747 0.42219383038871 no 1365 0.330993789552672 1520 2169061
SGTC_398 bronopol 33.3 µM 0.434478256224846 0.422784990731497 no 1366 0.331970590582811 1611 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_882 0843-0131 351 µM 0.433549807871372 0.422988886099056 no 1367 0.332307694790192 1591 5425421
SGTC_2789 5281112 71.43 µM 0.431932670570661 0.423344072803621 no 1368 0.33289517446827 1514 765948
SGTC_1897 st060201 15 µM 0.431531411159631 0.423432214749089 no 1369 0.333041009098812 1529 611878
SGTC_2123 5259487 200 µM 0.431239973530709 0.423496235287663 no 1370 0.333146945685157 1684 2173474
SGTC_1758 st042942 75.2445 µM 0.43056823938116 0.423643803819851 no 1371 0.333391169463284 1573 669317
SGTC_1143 3454-2408 5.08 µM 0.430437055334386 0.423672623967402 no 1372 0.333438872567607 1564 X1143
SGTC_1923 st058458 19.1 µM 0.429477797859677 0.423883378012631 no 1373 0.333787773933325 1705 3534982
SGTC_971 1315-0384 26.7 µM 0.429438348682701 0.423892045676277 no 1374 0.333802125477336 1534 6769120
SGTC_1800 st050079 29.0735 µM 0.429167359832584 0.423951587589055 no 1375 0.333900717334191 1566 3645560
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.428892333454086 0.42401201840626 no 1376 0.334000789859323 1640 5377381
SGTC_1165 k072-0275 30.3 µM 0.427344008241309 0.42435226110694 no 1377 0.334564391628435 1592 6153523 YGL055W OLE1
SGTC_552 k242-0005 476 µM 0.427323345838503 0.424356802028198 no 1378 0.334571915419863 1596 4088318
SGTC_2193 5925765 200 µM 0.424611395147565 0.424952887134123 no 1379 0.335559992373173 1632 877370
SGTC_1688 st021091 57.6 µM 0.422499243264574 0.425417255791883 no 1380 0.336330326472969 1699 3656366
SGTC_2017 5132927 60.65 µM 0.419155321781776 0.426152647389804 no 1381 0.337551310969216 1546 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3352 9151559 45.5865 µM 0.418761044044458 0.426239373502004 no 1382 0.337695388859768 1553 17159339
SGTC_3092 9117248 49.47 µM 0.418074989108251 0.426390288006243 no 1383 0.337946145357269 1691 17141857
SGTC_2546 rhodinyl acetate 100 µM 0.417053023873883 0.426615114148372 no 1384 0.338319812098533 1726 6708682
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.414619976127459 0.42715046570549 no 1385 0.339210061128486 1594 75037 A free radical scavenger.
SGTC_16 erodoxin 22.806 µM 0.414590688488512 0.427156910781093 no 1386 0.339220782919608 1612 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_573 3702-0553 84.7 µM 0.408444747567667 0.428509822031286 no 1387 0.341473593524469 1607 1222756
SGTC_2404 5161160 200 µM 0.406527371837575 0.42893206837239 no 1388 0.342177574700684 1666 2831543
SGTC_1826 st055655 41.6 µM 0.405369053050535 0.429187193904701 no 1389 0.342603127639495 1617 676168
SGTC_600 1495-0418 41.6 µM 0.404376917443239 0.429405740283001 no 1390 0.342967785725635 1621 5377768
SGTC_280 3448-3607 3.04 µM 0.401462140272705 0.430047928642061 no 1391 0.344039953408957 1706 626179
SGTC_2967 9089538 49.85 µM 0.400181739868573 0.430330087117445 no 1392 0.344511331455834 1800 728216
SGTC_3047 9092122 49.47 µM 0.396306304423423 0.431184322881133 no 1393 0.345939538466838 1591 17173831
SGTC_2287 7945887 168.79 µM 0.393831258849962 0.431730049018809 no 1394 0.346852812214345 1742 1245853
SGTC_2339 9000433 200 µM 0.392943444691931 0.431925836171668 no 1395 0.347180626443814 1567 2988954
SGTC_2517 totarol 10 µM 0.388546694662159 0.432895684600608 no 1396 0.348805752796029 1584 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1652 st011932 78 µM 0.386419081647259 0.433365145458359 no 1397 0.349593160208418 1731 1551076
SGTC_2767 sibutramine 71.45 µM 0.386313057578458 0.433388542286222 no 1398 0.349632415577588 1768 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1486 3970-0793 4.53 µM 0.385483749633731 0.433571557602837 no 1399 0.349939521958412 1733 2844330
SGTC_393 acivicin 6.25 µM 0.382919918546401 0.434137445017424 no 1400 0.35088957103799 1651 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2237 6667747 47.222 µM 0.381447059667225 0.43446259476262 no 1401 0.351435773592973 1625 729940 YDL015C TSC13
SGTC_1579 chlormadinone acetate 49.4 µM 0.380102041907043 0.434759560917045 no 1402 0.351934835060522 1764 45114258 A steroidal progestin.
SGTC_780 0109-0199 192 µM 0.376847080404953 0.435478375109404 no 1403 0.353143625279145 1793 610414
SGTC_493 zm226600 134 µM 0.37592379383725 0.435682309376171 no 1404 0.353486775426304 1685 5240098 A potassium channel opener. YCR052W RSC6
SGTC_281 1672-3440 14.9 µM 0.37529046905001 0.435822207177554 no 1405 0.353722226815397 1703 6833000
SGTC_2922 7999257 32.47 µM 0.373214866319172 0.436280752075537 no 1406 0.35449426626248 1635 2988377
SGTC_3287 9117173 37.0625 µM 0.372712556216844 0.436391735982612 no 1407 0.354681195129735 1676 2789709
SGTC_1994 st072947 40.9 µM 0.370902607078154 0.436791680273925 no 1408 0.355355036639117 1724 5286565 YDL195W SEC31
SGTC_1364 1653-0028 37.6 µM 0.370642375877702 0.43684918886048 no 1409 0.355451957600238 1678 5718652
SGTC_31 0508-1974 57.237 µM 0.369605156486498 0.437078417595368 no 1410 0.355838354228463 1720 6810525
SGTC_367 0335-0881 7.1 µM 0.368590143879176 0.437302759014356 no 1411 0.356216621572292 1760 23828853
SGTC_340 k038-0059 454 µM 0.36854850054004 0.437311963592907 no 1412 0.356232143927017 1706 23733424
SGTC_1886 st057356 49.9 µM 0.367446881084031 0.437555470849389 no 1413 0.356642853726742 1620 24207747
SGTC_1198 1612-1005 86.7 µM 0.367365435442407 0.437573474925386 no 1414 0.356673225195735 1763 6998509
SGTC_1932 st074806 40.9 µM 0.366843546485931 0.437688844857631 no 1415 0.356867861642235 1740 17251235
SGTC_1613 st002381 52.1 µM 0.366064312182939 0.437861113980825 no 1416 0.357158543378381 1663 551167
SGTC_2020 4017018 200 µM 0.366027862529505 0.437869172371861 no 1417 0.357172142409489 1668 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3077 9117319 49.47 µM 0.359261480906697 0.439365545752208 no 1418 0.359699743589667 1702 17154678
SGTC_234 nsc-17383 10.7 µM 0.358996347392162 0.439424197349199 no 1419 0.359798910877812 1781 408974
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.358280904734045 0.43958247086229 no 1420 0.360066553360354 1678 6708784 An antioxidant flavonoid
SGTC_2227 7312221 64.1025 µM 0.355570836639806 0.440182091951143 no 1421 0.36108099354973 1746 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1105 epirubicin 18.1 µM 0.355464483239596 0.440205626174902 no 1422 0.36112082403482 1645 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_913 3487-1245 167 µM 0.354976367871553 0.440313640627811 no 1423 0.361303647765915 1599 4016153
SGTC_1893 st059353 36.1 µM 0.35475652146815 0.440362291620892 no 1424 0.361386001640394 1654 3112488
SGTC_2182 6325192 200 µM 0.353612094956901 0.440615562444798 no 1425 0.361814804416538 1718 736248
SGTC_2390 9097792 176.6 µM 0.353105533598751 0.440727676325029 no 1426 0.362004662277015 1632 4497149
SGTC_356 1634-0012 32.5 µM 0.351836549715186 0.441008552987779 no 1427 0.362480423101298 1862 735457
SGTC_2053 5265679 138 µM 0.351503467281584 0.441082282316046 no 1428 0.362605335861219 1642 764595
SGTC_1621 st003705 32.4 µM 0.347388529704105 0.441993310335086 no 1429 0.364149724700788 1824 24207032
SGTC_2844 9010103 25.97 µM 0.345022810485024 0.442517208808655 no 1430 0.365038611100317 1703 2480525
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.344820251641109 0.442562071002462 no 1431 0.365114753591248 1735 165521
SGTC_2188 6126565 140.678 µM 0.336959836283044 0.444303538207169 no 1432 0.368073588651322 1800 874518
SGTC_1259 0671-0132 43 µM 0.336365245158868 0.44443531346768 no 1433 0.368297727249782 1708 X1259
SGTC_3265 9137266 49.47 µM 0.33587255400955 0.444544509971192 no 1434 0.368483487340489 1886 17224265
SGTC_2177 5811945 192 µM 0.335755757742154 0.444570396468774 no 1435 0.36852752772335 1806 5343475
SGTC_2044 5102272 200 µM 0.332319040734602 0.445332209111182 no 1436 0.369824181846124 1719 592666
SGTC_477 mead ethanolamide 10 µM 0.329644991156999 0.445925102068547 no 1437 0.370834111494322 1725 16061185
SGTC_2200 6600604 21.907 µM 0.329567541645532 0.445942276060446 no 1438 0.370863375771998 1724 2904777
SGTC_3195 9113082 49.47 µM 0.327544543938671 0.446390900208747 no 1439 0.371628029036214 1876 17018038
SGTC_307 1501-1223 22.3 µM 0.326275752193978 0.44667230514118 no 1440 0.37210786611587 1744 2830329
SGTC_1321 1326-2144 215 µM 0.326248112095839 0.446678435729484 no 1441 0.372118321379958 1846 3513030
SGTC_1296 1068-0102 11.9 µM 0.322984046990924 0.447402496299818 no 1442 0.37335366189575 1811 767053
SGTC_2768 sulfasalazine 50.2 µM 0.322190502989804 0.447578553051118 no 1443 0.373654189364117 1875 5384001 An antioxidant and salicylic acid derivative.
SGTC_2927 9011802 47.9 µM 0.321667479979813 0.447694597296815 no 1444 0.37385230834783 1673 43912568
SGTC_1437 4092-1038 11.6 µM 0.321276983049844 0.447781240614399 no 1445 0.374000248730192 1743 3977136
SGTC_2938 9059746 27.26 µM 0.31979324621136 0.44811047429185 no 1446 0.374562533865866 1765 6471769
SGTC_111 0083-0039 52.457 µM 0.314712385961312 0.449238160828474 no 1447 0.376490019575681 1773 759313
SGTC_3115 9123671 49.47 µM 0.312536802063593 0.449721153166361 no 1448 0.377316299379918 1805 3286988
SGTC_681 1642-0006 26.6 µM 0.311253366868875 0.450006118261028 no 1449 0.377804007757816 1750 4446530
SGTC_166 k072-0058 166.424 µM 0.311225209315056 0.450012370459521 no 1450 0.377814709881317 1872 5846229
SGTC_3026 9090633 49.47 µM 0.311034970265688 0.45005461210654 no 1451 0.377887018399178 1728 25236842
SGTC_1204 4049-0315 18.3 µM 0.310158706435288 0.4502491894873 no 1452 0.378220135293286 1860 588402
SGTC_1197 1601-0112 267 µM 0.310071653563189 0.450268520529152 no 1453 0.378253233907452 1715 7350313
SGTC_2198 6589944 200 µM 0.309079887911508 0.450488761251591 no 1454 0.378630378893531 1824 5290268
SGTC_86 0417-1630 471.922 µM 0.307740030773499 0.450786326614302 no 1455 0.379140078385915 1835 3634867
SGTC_2787 5284540 71.43 µM 0.305450258798896 0.451294920017951 no 1456 0.380011624253896 1747 736958
SGTC_3156 9099931 49.47 µM 0.302644441308603 0.451918243973019 no 1457 0.381080421247002 1778 18111053
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.302603865104746 0.451927259017707 no 1458 0.38109588428546 1873 23847180
SGTC_687 k029-0044 34.9 µM 0.301855496454345 0.452093532752908 no 1459 0.381381111401219 1911 5829338
SGTC_1413 3910-0535 34.4 µM 0.298391244365032 0.452863334809116 no 1460 0.382702285427513 1866 2876951
SGTC_155 k072-0202 43.6 µM 0.297710219051157 0.453014688459425 no 1461 0.382962171618167 1895 5857737
SGTC_1473 k844-0725 134 µM 0.297406137432864 0.45308227091803 no 1462 0.383078229282646 1823 54682906
SGTC_2084 5306078 60.6385 µM 0.296672284810102 0.453245376026754 no 1463 0.383358359210023 1850 679340
SGTC_2391 6285546 200 µM 0.29485674774001 0.453648928721722 no 1464 0.384051657005534 1747 846083
SGTC_2124 5246320 200 µM 0.294765941220948 0.453669114210768 no 1465 0.384086342989357 1820 579342
SGTC_1924 st058459 75.1 µM 0.294357649011599 0.453759875449421 no 1466 0.384242312610547 1813 688683
SGTC_820 1582-0060 59.9 µM 0.293836656207454 0.453875692951551 no 1467 0.384441361629126 1765 3848840
SGTC_2878 9043973 25.97 µM 0.292934815199788 0.454076182861302 no 1468 0.38478598842449 1888 6465167
SGTC_3169 9102970 49.47 µM 0.292394352222497 0.45419633977714 no 1469 0.384992562964115 1828 17027839
SGTC_742 0kpi-0133 140 µM 0.292282147016166 0.454221286010843 no 1470 0.385035453879223 1919 2728852
SGTC_2119 5528445 120.635 µM 0.290393839670005 0.454641134510873 no 1471 0.385757477995506 1891 791935
SGTC_80 0159-0065 512.242 µM 0.289639852491416 0.454808791100652 no 1472 0.386045887662122 1905 1548079
SGTC_2282 7944268 200 µM 0.289437439868453 0.454853800943634 no 1473 0.386123323791019 1868 2970414
SGTC_3196 9111891 49.47 µM 0.28850176586595 0.455061871281205 no 1474 0.386481339492942 1807 18891510
SGTC_785 1270-0111 65.3 µM 0.28846854863768 0.455069258183301 no 1475 0.386494051135227 1781 6741994
SGTC_568 1193-0097 7.48 µM 0.286787558352057 0.455443099811794 no 1476 0.387137494984353 1861 3646150
SGTC_313 3474-0040 5.03 µM 0.283057129419398 0.456272864127519 no 1477 0.388566521973351 1780 1043375 YIL048W NEO1
SGTC_972 1319-0219 195 µM 0.280773733116789 0.456780857367579 no 1478 0.389441975730565 1774 23903702
SGTC_1720 st037298 9.481 µM 0.280651831173296 0.456807979210256 no 1479 0.389488728739359 1783 597396
SGTC_989 1501-0895 10.3 µM 0.279286193664685 0.457111832270469 no 1480 0.390012600388059 1952 2830112
SGTC_2858 9025781 8.96 µM 0.277019487140804 0.457616227603172 no 1481 0.390882571454709 1922 4894980 YPL153C RAD53
SGTC_938 3126-1755 342 µM 0.276884379685341 0.457646294342933 no 1482 0.390934443535736 1955 1777771
SGTC_466 geldanamycin 89.2 µM 0.274617414609182 0.458150819540496 no 1483 0.391805092818547 1944 5288382 HSP90 inhibitor.
SGTC_2643 anethole 100 µM 0.273865282534258 0.458318225492996 no 1484 0.392094076212601 1835 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2724 maprotiline 69.64 µM 0.273403971342831 0.458420905587027 no 1485 0.392271350176567 1888 4011 A tricyclic antidepressant.
SGTC_2760 etidronate 98.04 µM 0.272083607001279 0.458714811741835 no 1486 0.392778866972659 1801 3305 A chelator and antioxidant.
SGTC_171 k064-0041 9.68 µM 0.272071857961632 0.458717427117787 no 1487 0.392783383845141 1760 53325
SGTC_2673 kobusone 100 µM 0.270351875884235 0.459100320164654 no 1488 0.393444779720204 1877 6710676 An epoxy ketone and protein crosslinker.
SGTC_766 1391-0721 126 µM 0.268877777261485 0.459428506184498 no 1489 0.394011869302229 1927 1020919 YIL115C NUP159
SGTC_122 0236-0016 402.397 µM 0.268781272912591 0.459449992401704 no 1490 0.394049002629785 1832 6808838
SGTC_1531 st059297 52.4 µM 0.263684089250327 0.460585022004217 no 1491 0.396011678348469 1871 7566702
SGTC_1314 1222-0010 41.1 µM 0.262409629851516 0.460868866367651 no 1492 0.396502824598684 1864 3526027
SGTC_511 blebbistatin 171 µM 0.262312154814218 0.460890576583231 no 1493 0.396540395925133 1927 3476986 A myosin inhibitor.
SGTC_409 arachidonic acid 100 µM 0.2616557059768 0.46103678777525 no 1494 0.396793446259383 1853 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2885 9057732 51.95 µM 0.258478524215419 0.461744517210429 no 1495 0.398018810559643 1848 6471414
SGTC_1870 st057514 26.5 µM 0.257805155930833 0.461894528216331 no 1496 0.398278642555543 1820 5393161
SGTC_2268 7933382 153.85 µM 0.257466184257454 0.461970045381375 no 1497 0.398409458317708 1980 935025 YOR257W CDC31
SGTC_1107 amlodipine 47 µM 0.255038557210967 0.462510919602213 no 1498 0.399346659655206 1883 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1873 rapamycin 2 nM 0.254223146676414 0.46269260830783 no 1499 0.399661584718211 1822 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3079 9117512 49.47 µM 0.254000522319305 0.462742214529284 no 1500 0.399747577289011 1901 7185044
SGTC_1744 st037937 38.9 µM 0.252995742990293 0.462966111451519 no 1501 0.400135751407931 1898 1016152
SGTC_3345 9148410 3.559 µM 0.252414874543496 0.463095552848048 no 1502 0.400360202038098 1948 4903596
SGTC_1571 st070080 73.4 µM 0.247315554062915 0.464232057527701 no 1503 0.402332011106252 1935 4315245
SGTC_131 0141-0277 33.849 µM 0.245336399410592 0.464673238291404 no 1504 0.403097985054721 1961 1547771
SGTC_384 k007-0144 5.16 µM 0.244747284607651 0.4648045684878 no 1505 0.403326056691798 1897 6824886
SGTC_610 4215-0184 155 µM 0.24442408882798 0.464876619512564 no 1506 0.40345119363112 1882 5605015
SGTC_2867 9039098 71.43 µM 0.243003262060239 0.465193382402628 no 1507 0.404001435213152 1831 6463460
SGTC_2206 7254556 146.969 µM 0.242796780899391 0.465239417700945 no 1508 0.404081414719594 1976 4398905
SGTC_2423 st077119 87.2 µM 0.242782922855188 0.465242507390278 no 1509 0.404086782711455 1925 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1484 3473-2379 286 µM 0.241377362330539 0.46555589185355 no 1510 0.404631328179838 1994 671917
SGTC_1028 k015-0029 4.8 µM 0.239260697434491 0.466027864741576 no 1511 0.405451719658669 1840 4588309
SGTC_48 0382-0018 55 µM 0.238621654803099 0.466170367571628 no 1512 0.405699486011369 1992 762596
SGTC_3001 9076041 71.4286 µM 0.237953286793031 0.466319414432574 no 1513 0.405958662674183 1883 16004211
SGTC_47 0149-0135 24.25 µM 0.237686258912675 0.466378963289179 no 1514 0.406062221044233 1760 5239155
SGTC_1064 honokiol 6.76 µM 0.235580141954781 0.466848666573063 no 1515 0.406879242113629 1893 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2139 5578692 56.4705 µM 0.231959509471658 0.467656242557289 no 1516 0.408284731436138 2030 650991 YMR113W FOL3
SGTC_3069 9117009 49.47 µM 0.231635183866047 0.467728589384432 no 1517 0.408410688920516 2017 41904981
SGTC_481 bay k-8644 50 µM 0.227607060874445 0.468627224828168 no 1518 0.409975865119712 1857 2303 A calcium channel antagonist.
SGTC_698 k064-0052 127 µM 0.226691725768321 0.468831449730267 no 1519 0.410331730759993 1949 5088751
SGTC_1431 4049-0260 9.09 µM 0.226151345669802 0.468952020436423 no 1520 0.410541855399775 1959 3854841
SGTC_528 3492-0019 172 µM 0.225311507502884 0.469139412483245 no 1521 0.410868474060514 1982 2869262
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.224693683968483 0.469277271047793 no 1522 0.411108789223575 1849 688664
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.223733165700973 0.469491604393103 no 1523 0.411482468769529 1991 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1372 2752-0194 270 µM 0.223692188480115 0.469500748387976 no 1524 0.411498412315551 1904 823334
SGTC_60 0986-0278 202 µM 0.222889941068672 0.469679771723211 no 1525 0.411810582669446 1734 3110598
SGTC_3096 9117468 49.47 µM 0.222398805188022 0.469789372839622 no 1526 0.412001720927621 1996 41316311
SGTC_3310 9130229 44.1445 µM 0.221591907852929 0.469969443754922 no 1527 0.41231579124893 1994 7761258
SGTC_2817 7995342 71.43 µM 0.221467391856557 0.469997231864486 no 1528 0.412364261874973 1851 18879975
SGTC_1684 st024538 14.6195 µM 0.220936349200323 0.470115745758297 no 1529 0.412570997059356 1866 6732859
SGTC_696 1560-0013 611 µM 0.2195447282986 0.470426329220163 no 1530 0.413112870736161 1975 1650269
SGTC_2911 7942208 15.64 µM 0.21784902707386 0.470804801957288 no 1531 0.413773371860845 1893 1243384
SGTC_2016 5121758 140 µM 0.214611285837464 0.471527523916581 no 1532 0.415035197065065 1993 2795203
SGTC_1276 0871-0068 94.2 µM 0.214359537803356 0.471583722556179 no 1533 0.415133346208246 1999 3414906
SGTC_3123 9126162 49.47 µM 0.213214595684551 0.471839319318204 no 1534 0.415579792150572 1890 25239884
SGTC_2676 harmalol 100 µM 0.213167158790914 0.471849909376459 no 1535 0.41559829151848 2005 5459187 A monoamine oxidase inhibitor
SGTC_2387 9077560 195.08 µM 0.211848475326821 0.472144307054592 no 1536 0.416112624435175 1897 5303272
SGTC_3271 9137798 49.47 µM 0.210951542648193 0.472344557066037 no 1537 0.416462541881989 2031 6498326
SGTC_818 4072-2707 53.5 µM 0.210615743883987 0.472419529606948 no 1538 0.416593563018115 1926 882871
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.210514597438585 0.472442112389168 no 1539 0.416633029906119 1923 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1631 benzylvanillin 81.9 µM 0.208143152179604 0.472971605874201 no 1540 0.417558597177603 1938 75506
SGTC_2319 6033012 152.6 µM 0.207807165995616 0.473046628355395 no 1541 0.417689768551892 1897 847246
SGTC_1281 0884-0031 11.8 µM 0.203957442319265 0.473906302179272 no 1542 0.419193377956205 1903 1548255
SGTC_1611 st001856 99.4 µM 0.20257297178178 0.474215495348845 no 1543 0.419734408686589 1889 647478
SGTC_906 1165-0455 526 µM 0.202523497566211 0.47422654469124 no 1544 0.419753745296956 1910 3252859
SGTC_293 4049-0273 38.5 µM 0.202448446750709 0.474243306230971 no 1545 0.419783078691315 1994 1380311
SGTC_3285 9112818 20.8695 µM 0.201480386818454 0.474459512821762 no 1546 0.420161482012995 1992 17017947 YPR165W RHO1
SGTC_2669 eugenol 100 µM 0.199796034435726 0.474835714124774 no 1547 0.420820051430912 2063 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1930 st074634 34.3 µM 0.197954271639838 0.475247098825027 no 1548 0.421540420805714 1861 684253 YOR116C RPO31
SGTC_833 3852-0053 558 µM 0.197341285228018 0.475384024194641 no 1549 0.421780236790355 2002 3123681
SGTC_2694 st077685 81.9 µM 0.193394055103746 0.476265802630168 no 1550 0.423325185446734 1925 2838096
SGTC_99 0109-0120 622.8 µM 0.193313385784273 0.476283824713077 no 1551 0.423356771856548 2049 759414
SGTC_574 1315-0397 40 µM 0.191623160083347 0.476661443904743 no 1552 0.424018699787229 2042 6794277
SGTC_929 2805-0021 398 µM 0.191474476462659 0.476694662836493 no 1553 0.424076937707194 1964 3098024
SGTC_830 4076-0286 57.8 µM 0.191266479491659 0.476741133843519 no 1554 0.424158410868121 1967 6866659
SGTC_1469 k284-2957 126 µM 0.19071371055819 0.476864635874721 no 1555 0.424374948189715 2016 23884841
SGTC_2942 9052777 62.25 µM 0.190182866213992 0.476983241511056 no 1556 0.424582918435711 1964 6469503
SGTC_3032 9089427 49.47 µM 0.188945067726185 0.477259808594548 no 1557 0.425067935378586 1960 17173707
SGTC_2790 5423970 71.43 µM 0.188742484379659 0.477305073782105 no 1558 0.425147326129078 2046 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2037 5169046 200 µM 0.187720618163672 0.477533403842409 no 1559 0.425547833321299 2005 5718022
SGTC_1301 naphtanilide LB 4.81 µM 0.187288852613031 0.477629881563293 no 1560 0.425717081335786 2068 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_619 1652-1634 108 µM 0.185908338921496 0.477938365185698 no 1561 0.426258321345482 1945 5400454
SGTC_3084 9116877 49.47 µM 0.185785514537431 0.47796581163473 no 1562 0.426306482245524 2085 27241325
SGTC_2894 9048625 32.47 µM 0.183174615273253 0.478549270082992 no 1563 0.427330505722316 2089 4092861
SGTC_3044 9093193 49.47 µM 0.180787920947604 0.47908266563888 no 1564 0.428267022284121 1920 25236277
SGTC_2076 5212012 200 µM 0.179969834575566 0.479265506115046 no 1565 0.428588125010036 2055 604802
SGTC_523 1934-0222 13.7 µM 0.17987575265026 0.479286533495601 no 1566 0.428625055640815 1907 1361595
SGTC_2891 9063876 19.48 µM 0.179690093685337 0.479328028581963 no 1567 0.428697935475491 2141 6472478
SGTC_1946 st076057 65.1 µM 0.179474684000153 0.479376173284355 no 1568 0.428782496907408 1986 953009
SGTC_1686 st019653 115.5 µM 0.179302766729553 0.479414597519259 no 1569 0.42884998726144 2084 97252
SGTC_2708 st078559 56 µM 0.179242569865037 0.479428051817549 no 1570 0.428873619513419 2084 17250902
SGTC_2277 7947813 106.88 µM 0.178861879656903 0.479513138512625 no 1571 0.429023077832784 2070 1246798
SGTC_1719 st032227 49.2 µM 0.176187816718537 0.480110834764277 no 1572 0.430073195957891 1938 3125804
SGTC_1948 st076329 66.6 µM 0.17596260390238 0.480161175526305 no 1573 0.430161660872619 2107 24208413
SGTC_1936 st074407 74.3 µM 0.175715291069942 0.480216456565557 no 1574 0.430258810841932 1913 809813
SGTC_884 0851-0618 334 µM 0.174995049213801 0.480377452066899 no 1575 0.430541761858097 2087 9642473
SGTC_1498 4478-3555 97.6 µM 0.174538842089893 0.480479429600985 no 1576 0.430721003821021 2114 3437919
SGTC_2428 5615643 7.78 µM 0.173209797259571 0.480776522782013 no 1577 0.43124326146994 2047 2253075
SGTC_1157 4092-0394 27.6 µM 0.172607825773661 0.480911090331787 no 1578 0.431479850078076 2074 3659885
SGTC_1051 3253-3903 78 µM 0.171833353394051 0.481084222743704 no 1579 0.431784271644916 2068 5509239
SGTC_1014 4130-3005 69.3 µM 0.171572380194891 0.481142563808303 no 1580 0.431886861417326 1936 743608
SGTC_806 3966-4455 5.86 µM 0.170461070696627 0.481391003707743 no 1581 0.432323773671596 1938 714982
SGTC_2874 9043904 71.43 µM 0.169876212845077 0.481521755094897 no 1582 0.432553744300082 1973 4463428
SGTC_3281 9140613 49.47 µM 0.169004760035614 0.481716581611343 no 1583 0.432896448646511 1904 16013766
SGTC_2818 7996756 12.99 µM 0.168150812981443 0.481907498686499 no 1584 0.43323231771155 2023 2241621
SGTC_2148 5546263 113.568 µM 0.166975823362332 0.482170198071073 no 1585 0.433694536002084 2001 792097
SGTC_1847 st056231 15 µM 0.166750706637846 0.482220529636967 no 1586 0.433783102958295 2106 5393180
SGTC_2830 7992007 71.43 µM 0.165695129146349 0.482456539271914 no 1587 0.434198439723629 1917 1952075
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.163408261800112 0.482967865891612 no 1588 0.435098499170745 2082 616764
SGTC_716 1683-5115 658 µM 0.162212837710403 0.483235165077107 no 1589 0.435569125328914 2141 723597
SGTC_231 b-estradiol 524 µM 0.161854008437574 0.483315401486479 no 1590 0.435710410559456 1987 450 A steroid.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.161734275197382 0.483342174718235 no 1591 0.435757556083004 1968 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2185 6113692 200 µM 0.161656804543175 0.483359497765443 no 1592 0.435788061002086 2011 874150
SGTC_415 dibenzyl ketone 100 µM 0.161185252523592 0.483464941179783 no 1593 0.435973748010788 2103 7593
SGTC_533 1222-0222 6.71 µM 0.160350552306545 0.483651590736937 no 1594 0.436302469520801 2115 3982874
SGTC_2258 7960471 200 µM 0.160210369453692 0.483682937753608 no 1595 0.436357680631574 1965 2974708
SGTC_1672 st016598 6.51 µM 0.159122332136719 0.48392624285023 no 1596 0.436786246940402 1973 4665860 YNL267W PIK1
SGTC_2449 5812982 45.77 µM 0.158825623178121 0.483992593456899 no 1597 0.436903130336278 2109 776185
SGTC_897 1000-0139 31.4 µM 0.157552234630535 0.484277355972018 no 1598 0.437404822296495 2135 6151020
SGTC_2051 5263410 176 µM 0.156333728290062 0.484549852920626 no 1599 0.437884985922487 2163 227584
SGTC_1009 4106-0057 9.87 µM 0.1557673755688 0.484676509947937 no 1600 0.438108193601239 2165 2928005
SGTC_1354 1498-1681 81 µM 0.154319791785361 0.48500024922581 no 1601 0.438678796326221 2017 5754243
SGTC_369 0957-0393 4.5 µM 0.154278838221546 0.485009408272056 no 1602 0.438694941096288 1976 6997992
SGTC_7 0192-1582 4.227 µM 0.153758844281318 0.485125702831073 no 1603 0.438899942681565 2070 252616
SGTC_3240 9133527 49.47 µM 0.153254076356924 0.485238593362939 no 1604 0.43909895726542 2025 17617455
SGTC_132 0417-1715 25.805 µM 0.152809632367037 0.48533799352395 no 1605 0.439274200710952 2162 6769098
SGTC_2529 gangaleoidin 93.61 µM 0.151946256961452 0.485531090542045 no 1606 0.439614662028616 2046 4565183
SGTC_1383 3049-0032 20.7 µM 0.150726178141638 0.485803971337369 no 1607 0.44009586098863 2131 712864
SGTC_3028 9087778 49.47 µM 0.150451508061766 0.485865404510921 no 1608 0.440204203068946 2076 17217395
SGTC_1470 k295-0292 231 µM 0.150101064210892 0.4859437858608 no 1609 0.440342440189723 2115 5045612
SGTC_2712 st079126 47.7 µM 0.147883174563171 0.486439858352342 no 1610 0.441217483475139 2074 3152970
SGTC_1443 4112-3303 14 µM 0.146703476211732 0.486703728545403 no 1611 0.441683037337491 2080 704433
SGTC_3180 9109287 49.47 µM 0.146004847677043 0.486859997724334 no 1612 0.441958780773471 2062 18891271
SGTC_2646 retinol 96.75 µM 0.144658173978689 0.487161227269562 no 1613 0.442490382020496 2109 445354 A vitamin A analog and teratogen.
SGTC_1390 3413-2614 145 µM 0.144407238030351 0.487217358475611 no 1614 0.442589450798212 2014 3421432
SGTC_1682 st012968 530 nM 0.144162571201418 0.48727208760256 no 1615 0.442686048002595 1970 24207270
SGTC_2453 5731132 22.18 µM 0.14120474424358 0.487933737790955 no 1616 0.443854099132973 2146 1362040
SGTC_2979 9012552 45.46 µM 0.140889909795529 0.48800416657327 no 1617 0.443978456725667 2194 17100905
SGTC_2520 obtusaquinone 4.71 µM 0.140412571986398 0.488110948233543 no 1618 0.44416701262426 2144 5967872
SGTC_64 000l-0018 272.079 µM 0.1390067808818 0.488425432137518 no 1619 0.444722395352376 1967 6811119
SGTC_1512 0259-0544 12.2 µM 0.135755831590756 0.489152716234969 no 1620 0.446007154499119 2053 18476
SGTC_607 4491-0986 66.8 µM 0.134890551217285 0.489346298072719 no 1621 0.446349205153629 2158 698981 YDR232W HEM1
SGTC_1925 st057770 10.1 µM 0.133932203218754 0.489560704067945 no 1622 0.446728092600612 1920 5989122
SGTC_2308 7584454 197.62 µM 0.133365796309413 0.489687424633289 no 1623 0.446952047159036 2142 893577
SGTC_680 0417-1641 114 µM 0.133047381639305 0.489758663076371 no 1624 0.447077954216092 2062 2835990
SGTC_2080 5212524 12.4 µM 0.132237615293474 0.489939832369601 no 1625 0.447398174827167 2199 260183
SGTC_3056 9094900 49.47 µM 0.131531217570603 0.490097876662895 no 1626 0.447677546518567 2052 25236784
SGTC_3209 9113616 49.47 µM 0.131171242925169 0.490178415373774 no 1627 0.447819922097535 2217 16649353
SGTC_747 3448-8087 38.7 µM 0.131057409361461 0.490203883941208 no 1628 0.447864946444951 2054 5168703
SGTC_2840 9008771 71.43 µM 0.131043646504051 0.49020696317864 no 1629 0.447870390084206 2172 2992978
SGTC_1732 st034308 51.822 µM 0.130427731965108 0.49034476561547 no 1630 0.44811401352541 1950 830119
SGTC_575 k072-0246 11.9 µM 0.128356110937798 0.490808270790339 no 1631 0.448933581090146 2144 6796779
SGTC_1913 st060213 96.1 µM 0.128244969625948 0.490833137940665 no 1632 0.448977556623685 2166 688959
SGTC_1642 st009582 77.7 µM 0.127345720755468 0.491034340366419 no 1633 0.449333387458578 2187 6739311
SGTC_2102 5377816 72.7585 µM 0.127135086135134 0.491081469138201 no 1634 0.449416741023607 2172 1379702
SGTC_1931 st074438 57.1 µM 0.126644324578139 0.491191275830369 no 1635 0.449610956712677 2182 2787313
SGTC_1396 3511-0007 98.6 µM 0.125511503538304 0.491444744288831 no 1636 0.450059309273945 2080 X1396
SGTC_251 melphalan 456.522 µM 0.125417363223204 0.491465808320505 no 1637 0.450096571391206 2116 460612 A DNA alkylator.
SGTC_720 r052-1644 49.9 µM 0.125370654550859 0.491476259462342 no 1638 0.450115059532006 2115 1422863 YOR257W CDC31
SGTC_1054 3429-0080 167 µM 0.12513299255182 0.491529436813843 no 1639 0.450209132143521 2148 1162877
SGTC_2506 ethyl hematommate 54.16 µM 0.124061350623296 0.491769220712358 no 1640 0.450633349711664 2000 3940691 An allergen.
SGTC_2842 9000675 19.48 µM 0.123092622008282 0.49198597993319 no 1641 0.45101687681737 1992 2989072
SGTC_1367 1812-0510 76.9 µM 0.121803711241151 0.49227438561562 no 1642 0.451527237346571 2142 1142582 YDR527W RBA50
SGTC_2995 9067767 71.4286 µM 0.12095054582124 0.492465291484874 no 1643 0.451865103117491 2098 11673567
SGTC_1811 st050069 61.5 µM 0.120906893633552 0.492475059225751 no 1644 0.451882390951004 2219 3877702
SGTC_2095 5432005 200 µM 0.120508632298057 0.492564175551797 no 1645 0.452040120947757 2123 783734
SGTC_627 1391-0720 175 µM 0.119760322499518 0.49273162092601 no 1646 0.45233650685885 2103 997839
SGTC_1065 prochlorperazine maleate 2.48 µM 0.119749230263677 0.492734102987381 no 1647 0.452340900403126 2193 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_351 caspofungin 25 nM 0.118247349967236 0.493070174767135 no 1648 0.452935836625583 2109 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2349 9023730 187.07 µM 0.1167388142212 0.493407740770433 no 1649 0.453533515622782 2166 4126287
SGTC_1403 3909-7815 62.9 µM 0.116136088847329 0.493542614344082 no 1650 0.453772343776626 2115 6615483
SGTC_1226 3909-7979 35.4 µM 0.114183593582602 0.493979534760676 no 1651 0.454546128633317 2179 6615510
SGTC_2849 9019321 12.99 µM 0.113941545387957 0.494033699707053 no 1652 0.454642065773503 2135 16489627
SGTC_864 0469-0573 172 µM 0.113169363864621 0.49420649730896 no 1653 0.454948141847189 2021 689425
SGTC_1818 st052136 56.3 µM 0.112451433935003 0.494367155547964 no 1654 0.455232737760394 2127 674169
SGTC_82 0054-0107 293.755 µM 0.111180091764232 0.494651658510358 no 1655 0.455736769109459 2223 3104697
SGTC_2539 epi(13)torulosol 80 µM 0.110014332399238 0.494912536379822 no 1656 0.456199004150386 2099 6708597
SGTC_303 1348-1668 34.2 µM 0.109346007280436 0.495062097593349 no 1657 0.456464028402314 2125 5380509
SGTC_3113 9123498 49.47 µM 0.108800119286267 0.495184259716811 no 1658 0.45668051460225 2235 8897275
SGTC_1414 3917-0015 5.4 µM 0.101627174892614 0.496789502329316 no 1659 0.459526304336828 2200 6618702
SGTC_1988 st071872 53.4 µM 0.101368074525307 0.496847487868638 no 1660 0.459629139370075 2246 16414116
SGTC_3061 glucosamine 200 µM 0.100727542850375 0.49699083636484 no 1661 0.459883373266056 2219 91431 and experimental redox chemotherapeutic
SGTC_2755 lomerizine 42.69 µM 0.0989341622394117 0.497392189974301 no 1662 0.460595272205029 2158 3949 A calcium channel blocker.
SGTC_3048 9093155 49.47 µM 0.098326075891455 0.497528278632896 no 1663 0.460836686468383 2249 25236002
SGTC_344 k064-0035 6.43 µM 0.0980127296156834 0.49759840509336 no 1664 0.460961092633553 2089 5088750
SGTC_416 estradiol valerate 100 µM 0.0977242330175657 0.497662970296211 no 1665 0.461075636245152 2128 13791 A steroid.
SGTC_1380 2291-0730 164 µM 0.0963559388508705 0.497969193742956 no 1666 0.461618942469246 2127 2999191
SGTC_1680 diphenhydramine 100 µM 0.0962955932168352 0.497982699089984 no 1667 0.461642905463658 2077 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_154 3389-1638 511.116 µM 0.0961354676450652 0.498018535188537 no 1668 0.461706491321368 1980 5238686
SGTC_2419 paclitaxel 166.5 µM 0.0955913530395483 0.498140308140016 no 1669 0.461922566512548 2079 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1940 st075990 51.1 µM 0.095238325057037 0.498219315962568 no 1670 0.462062764664115 2166 1084979
SGTC_2583 asiatic acid 100 µM 0.0934429286146557 0.498621127515911 no 1671 0.462775843791636 2193 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2019 4016004 108 µM 0.0920777511238289 0.498926656587465 no 1672 0.463318132688001 2156 45595336
SGTC_3290 9121031 71.43 µM 0.0919686495761147 0.498951073731116 no 1673 0.463361474006182 2158 17014854
SGTC_3141 9094609 49.47 µM 0.090117231326959 0.499365425347186 no 1674 0.464097028157263 2072 25236309 YDL196W YDL196W
SGTC_143 4032-1194 15.74 µM 0.0900761736800412 0.49937461415138 no 1675 0.464113341443142 2198 1806963
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0892873578992809 0.499551153157102 no 1676 0.464426770437343 2146 689007
SGTC_2362 9071156 126 µM 0.0885134770822248 0.499724349765062 no 1677 0.464734286609587 2230 653133
SGTC_686 1319-0111 510 µM 0.0874390032137782 0.499964819985406 no 1678 0.465161284001681 2227 4562600
SGTC_3304 9125678 46.087 µM 0.0871246191463741 0.499964819985406 no 1679 0.465286228270508 2203 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2340 7987427 183.45 µM 0.0867456486990207 0.499880005346303 no 1680 0.465436845366605 2204 2239331
SGTC_2771 fluoxetine 41.05 µM 0.0865716191949398 0.499841057061326 no 1681 0.465506012891196 2206 3386 A selective serotonin reuptake inhibitor.
SGTC_772 k072-0172 35.3 µM 0.0864652396189022 0.49981724901832 no 1682 0.465548293660274 2060 5861980
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0839661835288704 0.499257953731491 no 1683 0.466541659212358 2219 688669
SGTC_496 calpeptin 138 µM 0.0825652582941022 0.4989444235687 no 1684 0.467098613392535 2145 73364 A calpain inhibitor.
SGTC_1323 1348-1351 11.2 µM 0.0822600860214415 0.498876125419604 no 1685 0.467219946775039 2131 6989654
SGTC_998 3996-0085 177 µM 0.0810389424258075 0.498602831453776 no 1686 0.467705491378952 2221 715391
SGTC_889 0919-1524 82.7 µM 0.0810116154745346 0.498596715643696 no 1687 0.467716357527948 2113 3905452
SGTC_1444 4112-3581 28 µM 0.0801649178808305 0.498407223703414 no 1688 0.468053045903669 2224 2877249
SGTC_3346 9158254 43.5805 µM 0.0797329119118105 0.498310540383486 no 1689 0.468224841426679 2182 17639500
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0792655354678912 0.498205941231752 no 1690 0.468410709365869 2126 61125 An anti-inflammatory.
SGTC_2508 celastrol 40.54 µM 0.079177203974462 0.498186172599786 no 1691 0.468445838125643 2259 122724 Celastrol is a natural product and antioxidant.
SGTC_2125 5246583 200 µM 0.0777607777339634 0.497869176347376 no 1692 0.469009173385277 2263 835267
SGTC_3328 9140624 29.0385 µM 0.0769132402942663 0.497679498063143 no 1693 0.469346282258956 2250 4904392
SGTC_1983 st071813 46.9 µM 0.0768591288703257 0.497667387981799 no 1694 0.469367805881414 2145 11838595
SGTC_950 1165-0508 94.1 µM 0.0733719838994728 0.496886973533462 no 1695 0.470755055549645 2201 6148369
SGTC_2495 cafestol 54.53 µM 0.072597324726808 0.496713608232296 no 1696 0.471063277831637 2219 16667697 An anti-infammatory.
SGTC_2659 sanguinarine 24.21 µM 0.0701487002271389 0.496165621121357 no 1697 0.472037652482957 2272 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1341 1486-1360 280 µM 0.0698430303436329 0.496097214567209 no 1698 0.472159298759388 2265 3976547
SGTC_3341 9147222 25.867 µM 0.0690194343219714 0.495912900728721 no 1699 0.472487075017386 2205 1939759
SGTC_560 2332-1943 155 µM 0.0682820203268454 0.495747874439513 no 1700 0.47278056821074 2293 21177716
SGTC_2644 guaiazulene 100 µM 0.0641700592728746 0.494827670513372 no 1701 0.47441740874133 2273 3515 A coloring agent.
SGTC_142 0335-0849 62.6745 µM 0.0640645407534754 0.494804057168953 no 1702 0.474459418100427 2280 3889043 YPR107C YTH1
SGTC_432 NS 1619 61.3 µM 0.063496315567829 0.494676897843305 no 1703 0.474685646538261 2166 4552 A K+/calcium channel activator.
SGTC_1322 1348-1070 12 µM 0.0632488110747097 0.494621510631371 no 1704 0.474784188469871 2276 6758089
SGTC_1565 sinapyl alcohol 95.1 µM 0.0628634267162017 0.494535268504265 no 1705 0.474937629234388 2224 5280507 A phenol propionate derived from cinnamic acid.
SGTC_187 1488-2104 32.728 µM 0.0624671749805193 0.494446594718858 no 1706 0.475095400720509 2260 2852859
SGTC_1389 3405-0187 19 µM 0.0614416037983502 0.494217092204213 no 1707 0.475503759944184 2216 799890
SGTC_3344 9148862 3.898 µM 0.0591437574497576 0.493702886772997 no 1708 0.476418803107325 2277 4905352
SGTC_3170 9103054 49.47 µM 0.0590270214969974 0.493676764210098 no 1709 0.476465292793948 2245 16432970
SGTC_1694 st024011 44.9 µM 0.0585332704772818 0.493566275482336 no 1710 0.476661930953315 2301 2787533
SGTC_1843 st055809 45.5 µM 0.0583630222940924 0.493528178449371 no 1711 0.476729734238391 2222 16413835
SGTC_2380 9035439 200 µM 0.0579085009385067 0.493426468901864 no 1712 0.476910755858877 2265 6462575
SGTC_3270 9137563 49.47 µM 0.057274368979097 0.493284568089811 no 1713 0.477163318710246 2277 17015724
SGTC_2667 digitoxin 100 µM 0.0568064036943996 0.493179851227648 no 1714 0.477349706383608 2317 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0566002411424137 0.493133718262973 no 1715 0.477431821225355 2304 6708561
SGTC_1102 cgs 12066b 26.1 µM 0.0563161221275787 0.493070141142408 no 1716 0.477544987808129 2224 6438352 A 5-HT1B full agonist.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0561535692187279 0.493033766866555 no 1717 0.47760973457899 2280 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1513 0337-0559 19 µM 0.0552127579969675 0.492823243778051 no 1718 0.477984482514369 2173 775073
SGTC_2720 fluspirilene 36.88 µM 0.0547715347102719 0.492724512978027 no 1719 0.47816023918004 2289 3396 An atypical antipsychotic.
SGTC_2968 9090663 33.37 µM 0.0545615231232611 0.49267751966713 no 1720 0.478243896585758 2180 25236811
SGTC_485 niflumic acid 177 µM 0.0545429134878074 0.492673355480908 no 1721 0.478251309717419 2290 4488 A COX2 inhibitor.
SGTC_1878 temozolomide 1 mM 0.0526687167120551 0.492253979890692 no 1722 0.478997932431595 2318 5394 DNA alkylating agent.
SGTC_2570 licareol 100 µM 0.0509425050772823 0.49186772543931 no 1723 0.47968566765364 2208 443158
SGTC_2075 5212009 200 µM 0.0506857069767505 0.491810265335418 no 1724 0.479787983094895 2306 780898
SGTC_2591 skatole 100 µM 0.0492001445237432 0.491477865264457 no 1725 0.480379898047199 2273 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_591 4299-0174 154 µM 0.0487969639371354 0.491387653134434 no 1726 0.480540550860626 2272 5509088
SGTC_364 0083-0097 67.7 µM 0.0470045669663965 0.49098660760249 no 1727 0.481254793820524 2259 5207356
SGTC_427 1354-0053 47.3 µM 0.045875750199275 0.4907340415734 no 1728 0.481704641179981 2262 6813657
SGTC_2739 tacrine 100.86 µM 0.0455696644650748 0.49066555734926 no 1729 0.481826624146922 2273 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2252 omeprazole 400 µM 0.0446185374871165 0.490452752093756 no 1730 0.482205683297981 2277 4594 A proton pump inhibitor.
SGTC_2977 9011197 71.43 µM 0.0442300315765517 0.490365828516552 no 1731 0.482360521867233 2322 2704722
SGTC_502 l-744,832 89.3 µM 0.0428201946415089 0.49005039814195 no 1732 0.482922432878366 2343 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1620 st003704 16.5 µM 0.0420950189005561 0.489888153097331 no 1733 0.48321147549728 2317 2834414
SGTC_355 1311-2252 105 µM 0.0411264500755673 0.489671455837014 no 1734 0.483597544163333 2278 5338538
SGTC_1454 4239-0054 42.6 µM 0.0386526705689601 0.489118012777203 no 1735 0.484583654299606 2318 1340767
SGTC_1146 3579-1023 7 µM 0.0357772547692455 0.48847474057066 no 1736 0.485729984759138 2334 X1146
SGTC_713 1488-1073 324 µM 0.0354924582390789 0.488411029061892 no 1737 0.485843530020731 2356 3312542
SGTC_213 1246-0773 967 nM 0.0337646099545943 0.488024500480414 no 1738 0.486532428504769 2289 6251622
SGTC_2003 4023581 200 µM 0.0333130489917932 0.487923485801023 no 1739 0.486712473972649 2304 16641307
SGTC_2321 7390090 138.78 µM 0.0332012928037353 0.487898485939332 no 1740 0.486757033591976 2303 649046
SGTC_665 3914-0008 307 µM 0.0311667425261683 0.487443365409363 no 1741 0.487568281320977 2343 1069549
SGTC_2961 9083290 32.55 µM 0.0290367022570842 0.486966901692397 no 1742 0.488417659379046 2364 17741490
SGTC_1487 3970-0795 2.82 µM 0.027572425833979 0.486639371878938 no 1743 0.489001587149033 2297 3765103
SGTC_975 1335-0046 28.5 µM 0.0273447228166122 0.486588440000082 no 1744 0.489092393270691 2328 16486740
SGTC_1633 st005664 67.9 µM 0.0270408709576543 0.486520475734029 no 1745 0.489213567814309 2356 2063822
SGTC_248 streptozotocin 5.23457 mM 0.0264842977176429 0.486395984862267 no 1746 0.489435528906537 2350 5300 DNA alkylating agent.
SGTC_1861 st057647 17.4 µM 0.0253847792243602 0.486150055250829 no 1747 0.48987402580814 2359 688668
SGTC_1134 3477-0009 42.5 µM 0.0248389283068883 0.486027966572924 no 1748 0.490091720164795 2360 3973534
SGTC_1798 st045719 60.953 µM 0.0248253038744465 0.486024919257672 no 1749 0.490097153851387 2371 3980186
SGTC_893 0958-0369 48.9 µM 0.0244659244260634 0.485944538775264 no 1750 0.490240481971471 2361 6819948
SGTC_1828 st055811 49 µM 0.0243380308069098 0.485915933629928 no 1751 0.490291488955029 2374 5877589
SGTC_865 0488-0499 301 µM 0.0241640717743905 0.485877025445453 no 1752 0.490360868163647 2363 9634651
SGTC_3004 9076122 71.4286 µM 0.0219971387688427 0.485392374277291 no 1753 0.491225118959256 2367 44782551
SGTC_2078 5212016 200 µM 0.0219965432869993 0.485392241096148 no 1754 0.491225356464673 2369 1899708
SGTC_1791 st048313 56.1 µM 0.019675188792417 0.484873076342232 no 1755 0.49215124171189 2369 1204976
SGTC_1210 3013-0140 750 nM 0.019051141061417 0.484733514064751 no 1756 0.492400154065739 2375 905973
SGTC_760 0568-0725 82.9 µM 0.018069009581864 0.484513873592636 no 1757 0.49279190034262 2370 3916171
SGTC_3227 9130768 49.47 µM 0.0174651613248166 0.484378833394533 no 1758 0.49303276292018 2370 17720899
SGTC_1799 st045822 46.1415 µM 0.0169942703934287 0.484273528040755 no 1759 0.493220593338403 2386 3674992
SGTC_2223 6903751 107.57 µM 0.0158131608286987 0.484009401313923 no 1760 0.493691724463489 2370 5598863
SGTC_2239 6685329 187.64 µM 0.0155812607872768 0.483957543271521 no 1761 0.493784227797407 2287 805680
SGTC_876 0720-0963 56.8 µM 0.0154256657644219 0.483922748892098 no 1762 0.493846293771126 2373 765861
SGTC_3295 9122362 53.5725 µM 0.015220328235128 0.483876831210358 no 1763 0.493928201976819 2342 4730473
SGTC_1206 3978-0017 132 µM 0.0148345258580474 0.483790558467223 no 1764 0.494082097478365 2332 3873677
SGTC_557 1315-0110 16.2 µM 0.0148147287543208 0.483786131479049 no 1765 0.494089994512259 2382 6833801
SGTC_2096 5468907 200 µM 0.0143601133034455 0.483684471845242 no 1766 0.49427134053978 2383 759785
SGTC_922 1866-0035 480 µM 0.0143278113897673 0.483677248636269 no 1767 0.494284225813248 2357 3156169
SGTC_36 0335-0881 14.2 µM 0.0128111398911303 0.483338103433747 no 1768 0.494889234438666 2369 23828853
SGTC_1436 4092-1007 8.32 µM 0.0115105236689636 0.483047280269726 no 1769 0.4954080668383 2388 2881121
SGTC_185 k048-0037 25.491 µM 0.00892407488349347 0.482468966583308 no 1770 0.496439856470014 2394 6827589
SGTC_1712 st032288 53.4 µM 0.00787389299162656 0.482234162975153 no 1771 0.496858803632399 2384 2883011
SGTC_745 0469-0705 296 µM 0.00744312123605008 0.482137851187207 no 1772 0.497030651657821 2392 3486736
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.00436218120603284 0.481449046493221 no 1773 0.498259747001246 2399 15053
SGTC_3003 9075612 71.4286 µM 0.00114235635135448 0.480729250577945 no 1774 0.49954426585128 2401 6501993
SGTC_3157 9099274 49.47 µM 0 0.4804738903498 no 1775 0.5 2406 17217662
SGTC_946 3434-1334 87.4 µM -0.000430244088097008 0.480377716452858 no 1776 0.499828357447661 2407 4047976
SGTC_2973 9094665 17.96 µM -0.00362299298987396 0.479664066696017 no 1777 0.498554638076731 2412 25237061 YIL048W NEO1
SGTC_2348 9022543 33.42 µM -0.00441336380250756 0.47948741137413 no 1778 0.498239328296051 2421 3162678 YDL140C RPO21
SGTC_11 0438-0307 1.3 µM -0.00518547825744971 0.479314840410498 no 1779 0.497931302749936 2417 4011476
SGTC_743 1275-0778 158 µM -0.00604529511208665 0.47912267214079 no 1780 0.49758829087185 2418 2849257 YMR203W TOM40
SGTC_1989 st071868 50.2 µM -0.00607002458804843 0.479117145197426 no 1781 0.497578425419326 2417 16414057
SGTC_599 1935-0052 86.5 µM -0.00631574780672473 0.479062227215525 no 1782 0.497480397918152 2418 9557311
SGTC_108 0509-0257 621.132 µM -0.011020412265195 0.478010834746143 no 1783 0.495603580590619 2429 536624
SGTC_1046 2001-0062 216 µM -0.0120061903763878 0.477790553445325 no 1784 0.495210338103102 2428 739778
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0123979125051586 0.477703021367091 no 1785 0.495054075218194 2425 97141
SGTC_2614 arthonioic acid 13.39 µM -0.0149439195383951 0.477134131003706 no 1786 0.494038460551268 2433 6710684
SGTC_2436 5633522 8.09 µM -0.0173856537483096 0.476588583549096 no 1787 0.493064477038773 2441 5724242
SGTC_2602 kawain 100 µM -0.0179749368975427 0.476456928773902 no 1788 0.492829423819665 2434 5369129
SGTC_2069 5228469 200 µM -0.0200343951048798 0.475996834916277 no 1789 0.492007967370302 2463 2835210
SGTC_2951 9072950 58.06 µM -0.0219936526563761 0.475559156109199 no 1790 0.491226509380531 2444 16488155
SGTC_2721 ifenprodil 61.44 µM -0.0230247121316317 0.47532883940418 no 1791 0.490815280370972 2453 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1388 3346-4487 254 µM -0.0232364772502793 0.475281536609324 no 1792 0.490730820908747 2465 3345614
SGTC_1588 farnesol 29.9 µM -0.0239634835660848 0.475119145047706 no 1793 0.490440868114801 2457 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1291 0993-0025 5.79 µM -0.0247402813340003 0.474945636126623 no 1794 0.490131062522819 2466 4353356
SGTC_1185 1319-0113 81.3 µM -0.0256859625912864 0.474734411072978 no 1795 0.489753910196761 2481 4672763
SGTC_2920 7982904 15.77 µM -0.0273509139817913 0.474362548894739 no 1796 0.489089924276593 2479 6456808
SGTC_1031 k035-0009 16 µM -0.0277513668435291 0.47427311220194 no 1797 0.488930227321519 2453 5180959
SGTC_320 4092-0846 5.34 µM -0.029156961332397 0.473959198598282 no 1798 0.48836970325407 2511 1359356
SGTC_1442 4112-3290 3 µM -0.0303609149067041 0.473690330621947 no 1799 0.487889607930559 2447 704353
SGTC_2859 9028643 45.46 µM -0.0306100109088925 0.473634703774822 no 1800 0.487790279170648 2508 17151580
SGTC_1959 st077091 55.8 µM -0.0311642496938248 0.473510935845822 no 1801 0.487569275334342 2455 821356 YKL052C ASK1
SGTC_2649 anisomycin 9.56 µM -0.0315353705490877 0.4734280616964 no 1802 0.487421292272419 2469 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_851 0394-0702 453 µM -0.0318071640282882 0.473367368845505 no 1803 0.487312916730077 2452 762646
SGTC_654 1124-0271 80.9 µM -0.0318453084471122 0.473358851054373 no 1804 0.487297707013631 2483 5403748
SGTC_3334 9142812 21.919 µM -0.0320258731100594 0.473318530456386 no 1805 0.487225708859504 2531 45283678
SGTC_3021 9087658 49.47 µM -0.0324367445698814 0.47322678272113 no 1806 0.487061879983037 2474 25237042
SGTC_1623 st003709 20.3 µM -0.0331825798056271 0.47306024109441 no 1807 0.48676449488691 2468 16192618
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0331986012294977 0.473056663634657 no 1808 0.486758106783122 2489 115019
SGTC_1554 st069299 38.7 µM -0.034465992599052 0.472773671875999 no 1809 0.486252780101169 2499 24207999
SGTC_995 3931-2021 34.6 µM -0.0357174763224917 0.47249424556833 no 1810 0.485753817676401 2500 730143
SGTC_2295 7971645 200 µM -0.0357687967123037 0.472482787243822 no 1811 0.485733356877306 2506 2978226 YKL099C UTP11
SGTC_1630 st005209 31.3 µM -0.036052404695524 0.472419466383846 no 1812 0.485620286591723 2459 3367314
SGTC_2170 morpholine 200 µM -0.0363724638030014 0.472348007956461 no 1813 0.485492685173948 2495 121171 Reacts with secondary amines.
SGTC_2991 9074669 71.4286 µM -0.0370871395218324 0.472188448136186 no 1814 0.485207763074939 2504 17333109
SGTC_1817 st052116 64.4 µM -0.0372923560455023 0.472142631939965 no 1815 0.48512595012354 2487 4361398
SGTC_1419 3993-2473 62.6 µM -0.0381985080282836 0.471940330828109 no 1816 0.484764705225158 2487 704026
SGTC_490 phenamil 164 µM -0.0385471849180256 0.471862489606396 no 1817 0.484625705646753 2488 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2740 felodipine 17.08 µM -0.0388149631723677 0.471802709527138 no 1818 0.484518957469194 2488 3333 L-type calcium channel blocker
SGTC_3190 9110366 49.47 µM -0.0427145686705553 0.470932215894505 no 1819 0.482964533024844 2481 17123768
SGTC_1727 st034309 9.9045 µM -0.0429087975872787 0.470888862531801 no 1820 0.482887117875325 2522 870305
SGTC_2369 9071472 200 µM -0.0456190144322401 0.470283957866105 no 1821 0.481806956811773 2565 17296037
SGTC_2719 novobiocin 32.65 µM -0.0462501767481464 0.470143095893489 no 1822 0.48155542498681 2502 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1109 tnp00067 928.257 nM -0.0469815654560629 0.469979870201348 no 1823 0.481263959968896 2501 676295
SGTC_1649 st011737 51.3 µM -0.0475390703485411 0.469855453944832 no 1824 0.481041795943077 2512 1761035
SGTC_2964 9083345 53.42 µM -0.0494283058768583 0.469433862359422 no 1825 0.480288985448967 2520 17741579
SGTC_1901 st060216 58.6 µM -0.053101708935581 0.468614224107784 no 1826 0.4788254349211 2500 688792
SGTC_1756 st041558 35.5 µM -0.0543835849174181 0.46832823310143 no 1827 0.478314778418841 2518 3955792
SGTC_1433 4060-0023 7.6 µM -0.0575341613109538 0.467625398263392 no 1828 0.477059847188006 2578 3840627
SGTC_3090 9117696 49.47 µM -0.0586976772718828 0.467365864949826 no 1829 0.476596454709288 2624 7923821
SGTC_21 0849-0113 22.993 µM -0.0592330934003752 0.467246439938412 no 1830 0.476383225592902 2507 1560156
SGTC_220 paclitaxel 373.376 µM -0.0593109144038897 0.467229082144204 no 1831 0.476352233991535 2532 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3095 9117207 49.47 µM -0.0593581639769034 0.467218543267014 no 1832 0.476333417291221 2496 17015229
SGTC_2612 dictamnine 15.46 µM -0.0605629940995743 0.466949817264178 no 1833 0.475853622914658 2582 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1010 4112-3296 15.2 µM -0.0639525438634088 0.466193891335504 no 1834 0.47450400695914 2527 704384
SGTC_223 busulfan 5 mM -0.065493497220011 0.465850273284005 no 1835 0.473890541844199 2603 2478 A DNA alkylator.
SGTC_1856 st057054 55.7 µM -0.0671510123558083 0.465480691481978 no 1836 0.473230741760396 2570 1266018
SGTC_585 0kpi-0023 191 µM -0.0675328034616792 0.46539556642421 no 1837 0.473078774119364 2544 64601
SGTC_2491 paeonol 100 µM -0.0710096118056264 0.464620442272174 no 1838 0.471695052844605 2535 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2131 toluylene red 5.2905 µM -0.0726057391495196 0.464264644358838 no 1839 0.471059929798003 2547 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2181 6316240 54.2555 µM -0.0732751640564985 0.464115429174712 no 1840 0.470793577385895 2582 12779990
SGTC_732 3970-1727 52.7 µM -0.0734888966366998 0.464067789125676 no 1841 0.470708539692315 2576 1275699
SGTC_762 1165-0429 115 µM -0.0736482442186014 0.464032271587974 no 1842 0.470645141004491 2509 5967793
SGTC_2144 5628481 200 µM -0.0746434202230273 0.463810459837353 no 1843 0.470249213060957 2544 2818399
SGTC_2515 chrysin 20.77 µM -0.0756803886244023 0.463579345074704 no 1844 0.469836689425224 2618 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_816 0325-0417 81.3 µM -0.0767542005156475 0.463340031758507 no 1845 0.469409542947766 2584 68101
SGTC_2128 5255449 168.493 µM -0.0781822935676982 0.463021782723302 no 1846 0.468841523293357 2551 736008
SGTC_2587 piperic acid 92.2 µM -0.0785176255696553 0.462947057762658 no 1847 0.468708155163845 2590 5370536
SGTC_2915 7971052 15.16 µM -0.0797369036810067 0.46267536640442 no 1848 0.468223253995373 2539 5741558
SGTC_3126 9127922 49.47 µM -0.0801770102320655 0.462577301870128 no 1849 0.468048237231939 2744 45595682
SGTC_2985 9022375 71.43 µM -0.0803260459011362 0.462544094260083 no 1850 0.467988971753876 2734 4939335
SGTC_2264 7948757 110.76 µM -0.0813837245901358 0.462308433482634 no 1851 0.467568396034127 2541 2971411
SGTC_1467 k284-1082 293 µM -0.0816694919431679 0.462244764090607 no 1852 0.467454769597234 2559 3334705
SGTC_2812 7970281 58.44 µM -0.0826067085798008 0.462035957625422 no 1853 0.467082133417353 2634 2233435
SGTC_72 0744-0168 198.391 µM -0.0855588294426449 0.461378310761911 no 1854 0.465908563870744 2605 677577
SGTC_2707 st078556 66.6 µM -0.0866082004412979 0.461144566700698 no 1855 0.46549147369374 2601 17250899
SGTC_406 estrone 100 µM -0.0877254358551626 0.460895720811135 no 1856 0.465047451334227 2588 5870 A steroid.
SGTC_911 3456-4043 236 µM -0.088032411715572 0.460827349643561 no 1857 0.464925457656171 2622 914281
SGTC_549 1661-1316 519 µM -0.088201704009591 0.460789644529704 no 1858 0.464858181496848 2593 2857282
SGTC_2665 lovastatin 100 µM -0.0899477266581721 0.460400787547139 no 1859 0.46416437722178 2582 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3147 9097027 49.47 µM -0.0903179703192129 0.460318335376109 no 1860 0.464017270131303 2601 25236841
SGTC_3286 9117135 37.221 µM -0.0921577931125087 0.459908637642417 no 1861 0.463286335750503 2605 3438150
SGTC_3087 9117406 49.47 µM -0.0922941797942279 0.459878268301088 no 1862 0.463232156242869 2667 42546093
SGTC_2963 9082507 9 µM -0.0937468716259037 0.459554810704289 no 1863 0.462655118013031 2685 16459611
SGTC_1158 4092-0494 91.8 µM -0.0940199577427838 0.459494008100275 no 1864 0.462546651487185 2695 1148199
SGTC_3080 9117754 49.47 µM -0.0955455029047857 0.459154363049761 no 1865 0.461940774728942 2595 9550191
SGTC_2146 5545642 200 µM -0.101812562344869 0.45775938994704 no 1866 0.459452727079737 2586 825326
SGTC_152 4469-0003 551.229 µM -0.104585297858834 0.457142376872787 no 1867 0.458352440664561 2592 697280
SGTC_672 1441-0018 53.7 µM -0.109306787957064 0.456091948582684 no 1868 0.456479581423443 2603 251141
SGTC_2819 7996655 46.38 µM -0.109342500051613 0.456084004582519 no 1869 0.456465419244705 2669 6456960
SGTC_2343 7990716 14.84 µM -0.112021043408415 0.455488224516849 no 1870 0.455403360679548 2624 6456862
SGTC_735 3076-0345 636 µM -0.114456365674538 0.454946630193008 no 1871 0.454438017084522 2698 2888990
SGTC_3070 9117005 49.47 µM -0.115646833590586 0.454681910972368 no 1872 0.453966222028088 2597 8779016
SGTC_1012 4112-3522 18 µM -0.116376494623998 0.454519669332922 no 1873 0.453677081686776 2608 3112398
SGTC_2497 7-hydroxyflavone 100 µM -0.118372579855986 0.454075874502184 no 1874 0.452886225555278 2790 5281894
SGTC_2490 carminic acid 95.39 µM -0.120296970449018 0.453648073999371 no 1875 0.45212395195863 2579 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_786 4544-0069 423 µM -0.120849203283196 0.453525320117412 no 1876 0.451905238540898 2746 748821 YLR208W SEC13
SGTC_182 3448-4371 550.524 µM -0.121539039116692 0.453371985190719 no 1877 0.451632047567586 2591 3491403
SGTC_491 tetrandrine 80.3 µM -0.121975839517232 0.453274897919086 no 1878 0.451459076323182 2709 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_944 3370-0224 231 µM -0.126066966101702 0.452365702875598 no 1879 0.449839458019279 2654 4580514
SGTC_2569 tetrandrine 100 µM -0.127416354604432 0.452065874892063 no 1880 0.449305436318774 2701 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_447 ml7 120 µM -0.127574478841067 0.452030742192431 no 1881 0.449242864502529 2681 4216 Selective myosin light chain kinase inhibitor.
SGTC_405 ebelactone b 50 µM -0.130006484180875 0.451490436627597 no 1882 0.4482806482991 2649 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_999 SEC7.066 22.7 µM -0.131107050592388 0.4512459591693 no 1883 0.447845311871806 2667 740511 YDR170C SEC7
SGTC_1553 gossypol 38.6 µM -0.134294156173968 0.450538087021749 no 1884 0.446584987041384 2617 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_632 0781-2353 4.65 µM -0.135386140664917 0.450295587853822 no 1885 0.446153290695098 2727 6811515 YHR007C ERG11
SGTC_326 k292-0812 17.5 µM -0.137486425473727 0.44982922567295 no 1886 0.445323160878163 2632 3579357
SGTC_539 4859-0462 2.54 µM -0.139137264571202 0.449462710212326 no 1887 0.444670840868599 2822 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_779 1360-0071 233 µM -0.139289517466398 0.449428909544985 no 1888 0.444610686491818 2849 7566
SGTC_2514 salinomycin 42.74 µM -0.141240863185492 0.448995736645612 no 1889 0.443839832735271 2790 23682228 A polyether potassium ionophore.
SGTC_1394 3474-0001 65.7 µM -0.147431777170827 0.447621840553058 no 1890 0.441395612506141 2733 5017666 YIL048W NEO1
SGTC_2412 st077135 33.4 µM -0.150379085135387 0.446967989644402 no 1891 0.440232770634359 2967 13258915
SGTC_1362 1611-0397 101 µM -0.150760495016341 0.446883385568828 no 1892 0.44008232520393 2687 27816
SGTC_3262 9137218 49.47 µM -0.150987449131689 0.446833043911114 no 1893 0.439992808266805 2627 17650664
SGTC_1889 st059080 5.18 µM -0.154288539048259 0.446100912379857 no 1894 0.438691116813863 2671 176925 Isolated from Daphnopsis sellowiana.
SGTC_2364 9055074 200 µM -0.155501575565513 0.445831925359288 no 1895 0.438212955964435 2767 6470630
SGTC_1033 k072-0102 21.3 µM -0.157040147733487 0.445490787713557 no 1896 0.437606603657851 2729 5965931
SGTC_2298 7976326 193.81 µM -0.158605522765221 0.445143748659285 no 1897 0.436989838671062 2733 2235818
SGTC_2563 tomatine 8.54 µM -0.158752228442956 0.44511122659104 no 1898 0.436932043781229 2667 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_653 0203-0016 55.2 µM -0.160473076419652 0.44472977250316 no 1899 0.436254214332894 2764 295302
SGTC_1862 st057513 3.81 µM -0.160806694676062 0.444655826474257 no 1900 0.436122826136781 2712 5393163
SGTC_981 1488-1094 54.9 µM -0.161578329054092 0.444484802156472 no 1901 0.435818961975413 2673 3449522
SGTC_100 0086-0128 49.5915 µM -0.164161328637176 0.443912383940829 no 1902 0.434802071661856 2738 93297
SGTC_2370 9071495 200 µM -0.169106990444711 0.442816703889023 no 1903 0.43285624327122 2765 21791103
SGTC_1349 flufenamic acid 69 µM -0.169230536159265 0.442789338680583 no 1904 0.432807655898486 2699 3371 A non-steroidal anti-inflammatory.
SGTC_2487 5918373 44.05 µM -0.170515523381851 0.442504731956811 no 1905 0.432302363620256 2687 2876279
SGTC_1578 josamycin 24.2 µM -0.171148514581589 0.44236454414485 no 1906 0.432053494737919 2723 5282165 A P450 substrate.
SGTC_1655 st012546 55.1 µM -0.174375993824405 0.441649870713135 no 1907 0.430784989714909 2818 720985 YLR208W SEC13
SGTC_558 k064-0027 21.3 µM -0.175001642627347 0.441511352740765 no 1908 0.430539171436972 2825 5088526
SGTC_1338 1486-1223 76 µM -0.175208309421625 0.441465598505587 no 1909 0.430457977677079 2788 3444526
SGTC_1091 telmisartan 47.6 µM -0.175854073790873 0.441322636913405 no 1910 0.430204293388869 2818 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1794 st048918 76.9 µM -0.179366760361735 0.440545120350166 no 1911 0.428824864743597 2691 672303
SGTC_1108 betulinic acid 729.144 nM -0.179850171358029 0.440438137483665 no 1912 0.428635097350994 2748 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_571 k831-0106 44.2 µM -0.179917446367262 0.440423249310095 no 1913 0.428608689239722 2758 4783639
SGTC_2738 aclarubicin 5.55 µM -0.180312387040875 0.440335849381807 no 1914 0.428453665800057 2807 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1978 st071761 42 µM -0.180547692440735 0.440283777942244 no 1915 0.428361308180628 2747 5147680
SGTC_3315 9136395 68.55 µM -0.18090548512855 0.440204602901737 no 1916 0.428220881691044 2752 16876844
SGTC_3181 9108277 49.47 µM -0.183806697491362 0.43956268951045 no 1917 0.427082550910821 2751 17097298
SGTC_1331 1472-0049 76.2 µM -0.184843758943538 0.439333270915921 no 1918 0.426675792267872 2723 24051409
SGTC_2057 5236571 38.335 µM -0.185483582595347 0.439191739372087 no 1919 0.426424878016649 2856 54684039 YBR257W POP4
SGTC_3135 9127742 49.47 µM -0.18595523996866 0.439087411855959 no 1920 0.426239931177844 2814 3643468
SGTC_233 rapamycin 362 pM -0.186148425210551 0.439044681769113 no 1921 0.426164183835877 2780 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_478 N-arachidonylglycine 10 µM -0.186412032132802 0.43898637645979 no 1922 0.426060828763459 2726 5283389
SGTC_2328 6201408 200 µM -0.186913559220472 0.438875450965522 no 1923 0.425864203917829 2840 2890418
SGTC_2374 9071832 200 µM -0.190313835131889 0.438123520348898 no 1924 0.424531606454554 2733 17381698
SGTC_2933 9026794 32.47 µM -0.190735748904456 0.438030234651826 no 1925 0.424366314625233 2794 17586027
SGTC_1219 1469-0211 33.1 µM -0.19273618551597 0.437587982409474 no 1926 0.423582791397794 2825 6822282
SGTC_2161 5662504 8.5105 µM -0.193214997207222 0.437482139288349 no 1927 0.423395296982594 2772 2859334
SGTC_2778 tioconazole 65.09 nM -0.193254275578789 0.437473456855362 no 1928 0.423379917017723 2711 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1534 6-azauridine 81.6 µM -0.193647234936474 0.43738659535813 no 1929 0.423226055024273 2722 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.194535823494341 0.437190188895191 no 1930 0.422878174190963 2880 5024745
SGTC_305 1682-2595 20.8 µM -0.196778157624589 0.436694630325374 no 1931 0.422000572302254 2804 226033
SGTC_40 0327-0103 19.753 µM -0.197351282977722 0.436567984833153 no 1932 0.421776325181634 2797 409036
SGTC_2993 9054257 71.4286 µM -0.19943790814674 0.436106951071289 no 1933 0.420960104817232 2745 6470217 YGL055W OLE1
SGTC_1081 sertraline 6 µM -0.202652059004694 0.435396963825844 no 1934 0.419703498466335 2881 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2592 piperlongumine 83.33 µM -0.203407054477044 0.435230219826026 no 1935 0.419408443195984 2850 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1378 2093-0007 380 nM -0.204261627034177 0.435041497694959 no 1936 0.419074527474868 2872 3618014
SGTC_2905 7799065 20.05 µM -0.20483190242653 0.434915567422559 no 1937 0.418851730450363 2923 1296806
SGTC_3264 9137442 49.47 µM -0.206128345281971 0.434629306811304 no 1938 0.418345328922942 3002 17015726
SGTC_620 0109-0052 432 µM -0.20781591731606 0.43425673441432 no 1939 0.417686351858478 2880 493037
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.208639957976338 0.434074828677353 no 1940 0.417364657506784 2854 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3163 9099914 49.47 µM -0.208837677260505 0.434031184517705 no 1941 0.417287478785636 2867 16268368
SGTC_1976 st070609 63.5 µM -0.208960480081913 0.434004077673137 no 1942 0.417239544930396 2712 682556
SGTC_3202 9113761 49.47 µM -0.209658362708741 0.433850036654279 no 1943 0.416967162475553 2961 4798415
SGTC_1971 st069429 63.5 µM -0.209940001286871 0.433787874469375 no 1944 0.416857250675513 2917 1246522 YGL099W LSG1
SGTC_1669 st015249 58.4 µM -0.211558287711525 0.433430724291627 no 1945 0.416225827129355 2861 722793
SGTC_1427 4048-4900 550 nM -0.21318584282935 0.433071583366897 no 1946 0.415591005123147 2907 24132586
SGTC_94 0334-0113 514.748 µM -0.216489217313631 0.432342821624846 no 1947 0.414303214611861 2810 6795178
SGTC_332 4112-0506 40.9 µM -0.21933227294211 0.431715795578527 no 1948 0.413195611857741 2791 2790355
SGTC_1734 st037168 69.4 µM -0.220693928175938 0.431415548063835 no 1949 0.412665379758675 2880 708907
SGTC_921 1561-0023 372 µM -0.221008876272097 0.431346107058167 no 1950 0.412542760800849 2768 24050882
SGTC_1903 st060211 78.3 µM -0.221069033039074 0.431332843696823 no 1951 0.412519340896015 2969 688960
SGTC_2989 9073649 71.4286 µM -0.223510167395393 0.430794687984641 no 1952 0.411569235417953 2775 21367202
SGTC_1266 0828-0227 32.9 µM -0.225656903530525 0.430321539420331 no 1953 0.410734139747857 2926 3913820
SGTC_401 neomycin 50 µM -0.227544178037171 0.429905659754056 no 1954 0.410000310454818 2850 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1730 st033808 45.1 µM -0.227593699606451 0.429894748229794 no 1955 0.409981059205208 2794 1045166
SGTC_316 k060-0003 58.6 µM -0.229463195523451 0.429482864940294 no 1956 0.409254461607544 2952 6152314
SGTC_1112 tnp00069 1.16933 µM -0.231080517280297 0.429126602018635 no 1957 0.40862612525063 2914 145826
SGTC_1073 triclabendazole 3.09 µM -0.231331208032668 0.429071385130614 no 1958 0.408528751808431 2882 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1632 st005650 90 µM -0.233326857814504 0.428631874946887 no 1959 0.407753802280862 2944 2759605
SGTC_1526 st051518 75 µM -0.233389271819787 0.428618130677309 no 1960 0.407729571514396 2874 673993
SGTC_2104 5389443 200 µM -0.233872865446509 0.428511640828719 no 1961 0.407541839656054 3003 2244536
SGTC_2275 7947463 200 µM -0.23457399355472 0.428357257993639 no 1962 0.407269698262366 2808 1225414
SGTC_2824 7998404 51.95 µM -0.234776435083188 0.42831268401738 no 1963 0.407191129331976 2798 837851
SGTC_2091 4-phenylthiadiazole 200 µM -0.235226957232722 0.428213490442422 no 1964 0.407016292036274 2835 270010
SGTC_3277 9138724 49.47 µM -0.235839385184595 0.42807865658225 no 1965 0.406778652536011 2887 15943418
SGTC_6 0844-0013 19.835 µM -0.236226421624644 0.42799344988028 no 1966 0.406628489059496 2882 1584900
SGTC_1479 0549-0158 134 µM -0.238597243881685 0.427471582922074 no 1967 0.405708951239275 2869 5440202
SGTC_804 1595-0054 20.9 µM -0.238814868951878 0.427423685492222 no 1968 0.405624570016753 2839 761523 Stimulates phospholipase C.
SGTC_1965 Pectolinarigenin 58.4 µM -0.242158054887079 0.426688013515701 no 1969 0.404328847608277 2832 5320438 An anti-inflammatory.
SGTC_1072 oxiconazole 14.9 nM -0.243239054899203 0.426450192623882 no 1970 0.403910106874101 2835 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3151 9099821 49.47 µM -0.243540473324512 0.426383885086251 no 1971 0.403793367766977 2963 17174189
SGTC_2525 harmine 47.85 µM -0.245991972990466 0.425844669333974 no 1972 0.402844223123033 2895 5280953 A monoamine oxidase inhibitor
SGTC_3129 9127257 49.47 µM -0.247085190533973 0.42560425702404 no 1973 0.402421147354155 2868 837894
SGTC_1689 st020265 53.493 µM -0.25201773704699 0.424519873060625 no 1974 0.400513677007466 2973 5758320 YPR016C TIF6
SGTC_1908 st060353 56.5 µM -0.25627234290107 0.423584987726948 no 1975 0.398870275741086 3068 4227716
SGTC_199 4063-0024 41.6 µM -0.256683997457958 0.4234945555905 no 1976 0.398711362964335 2977 306215
SGTC_2314 7727897 200 µM -0.259575632127066 0.42285943607941 no 1977 0.397595567454076 2881 900724
SGTC_1789 tunicamycin 25 nM -0.262201823797749 0.42228279219391 no 1978 0.396582923691539 2989 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2692 st077426 47.7 µM -0.268879391452449 0.420817323601739 no 1979 0.394011248195595 3058 25238571
SGTC_1003 4049-0218 100 µM -0.270271875954478 0.420511864458329 no 1980 0.393475550113408 3042 295161
SGTC_1425 4048-4433 7.33 µM -0.270732366231152 0.420410860594945 no 1981 0.393298440734684 2944 23734946
SGTC_957 1187-1561 14.1 µM -0.273156343578319 0.419879272337757 no 1982 0.392366518496373 2856 1538454
SGTC_2160 5660466 132.927 µM -0.273699922591254 0.419760083240013 no 1983 0.392157618624044 2905 2859134
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.273973388553567 0.419700123881304 no 1984 0.392052536164722 2959 77254
SGTC_3149 9097855 49.47 µM -0.277989147585443 0.418819855519258 no 1985 0.390510344760874 3056 25236625 YMR079W SEC14
SGTC_3294 9122953 26.2835 µM -0.279901264336157 0.418400855383695 no 1986 0.38977662858961 2877 16459826
SGTC_3142 9086498 49.47 µM -0.280221419760378 0.418330709096667 no 1987 0.389653817064528 3028 25236367
SGTC_2450 5739737 12.93 µM -0.284388851712773 0.417417859458176 no 1988 0.388056200752596 3004 2262825
SGTC_1477 0139-0234 16 µM -0.286086794966639 0.417046062996875 no 1989 0.387405822581478 2908 620880
SGTC_664 1222-0054 14.9 µM -0.286330907893116 0.416992615992524 no 1990 0.38731234378426 2925 6813991
SGTC_822 1487-0950 154 µM -0.2867144507585 0.416908644770702 no 1991 0.387165485917391 3057 1958375
SGTC_2962 9082311 13.18 µM -0.287553516218927 0.416724956617575 no 1992 0.386844265610178 2886 16459453
SGTC_1814 st052110 31.539 µM -0.28910665136396 0.416384992379578 no 1993 0.386249881894193 3045 674163
SGTC_1739 st037196 92.5 µM -0.290070589541256 0.416174028327708 no 1994 0.38588111754945 3104 612214
SGTC_3355 9151058 44.0485 µM -0.290893193936024 0.415994015175316 no 1995 0.385566503397179 2938 17015728
SGTC_3226 9131256 49.47 µM -0.290996815551833 0.415971340574517 no 1996 0.385526877498032 2918 17178073
SGTC_1511 0906-3109 28.5 µM -0.291297295970925 0.415905590686461 no 1997 0.385411977662888 2908 2882180
SGTC_2167 5876490 200 µM -0.292014150641572 0.415748741008588 no 1998 0.385137902319098 3129 686534
SGTC_63 0099-0242 26.702 µM -0.292136828771763 0.41572190005692 no 1999 0.385091004483826 3072 3898502 YLR359W ADE13
SGTC_2886 9058944 51.95 µM -0.294809013399922 0.415137346112653 no 2000 0.384069890300379 2962 4949929
SGTC_2640 pentamidine 10.38 µM -0.296507984027669 0.414765785249561 no 2001 0.383421085295605 3031 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3054 9094397 49.47 µM -0.297621351415603 0.414522335762094 no 2002 0.382996088301545 2975 2598354
SGTC_404 fumagillin 50 µM -0.297937261830377 0.414453264603225 no 2003 0.382875523921906 2988 12015870 A methionine aminopeptidase binder.
SGTC_1774 st048371 48.465 µM -0.298495063990831 0.414331312306041 no 2004 0.382662671437686 2919 4242727
SGTC_260 nsc-65238 3.989 µM -0.300389603851808 0.413917170746337 no 2005 0.381939996336227 3053 3246252
SGTC_885 0865-0106 16.8 µM -0.300613201072896 0.413868299272836 no 2006 0.381854731917915 2941 2793380
SGTC_1153 4055-0057 267 µM -0.301836189759917 0.413601015192518 no 2007 0.381388470650352 2925 882706
SGTC_2670 beta-carotene 100 µM -0.302031131683895 0.413558414346056 no 2008 0.381314165431757 3051 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3022 9087993 49.47 µM -0.304280093071168 0.413067020349486 no 2009 0.380457255003172 3015 17173644
SGTC_3276 9139060 49.47 µM -0.305602038802554 0.412778241091815 no 2010 0.379953833980556 2917 4870619
SGTC_1285 0929-0069 65.5 µM -0.306487075814308 0.412584930981736 no 2011 0.379616909346673 2968 1206237
SGTC_583 1488-1091 88.9 µM -0.307036012862079 0.412465042599292 no 2012 0.379407980467977 3034 4303273
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.308139694863121 0.41222402210956 no 2013 0.378988018808677 3028 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2431 5490079 200 µM -0.308692171345107 0.412103385515557 no 2014 0.378777849775395 3013 5722345
SGTC_3258 9138477 49.47 µM -0.308943836892915 0.412048435567939 no 2015 0.378682124899647 2977 4970355
SGTC_3060 1327-0027 12.5 µM -0.309754275181264 0.411871492034788 no 2016 0.378373912787772 3016 16000455 YPR107C YTH1
SGTC_699 0375-0592 111 µM -0.310356801398317 0.411739953693295 no 2017 0.378144820388393 3084 762578
SGTC_3007 9078383 71.4286 µM -0.313990778103232 0.410946825952064 no 2018 0.376764021422661 2990 6496995
SGTC_3049 9092223 49.47 µM -0.314594856880935 0.410815018898644 no 2019 0.376534642325342 3056 8623917
SGTC_2803 7707263 71.43 µM -0.317020078719574 0.410285948792394 no 2020 0.375614183428273 2966 2199229
SGTC_649 1123-0311 367 µM -0.321659939684168 0.409274203564496 no 2021 0.373855164824944 3073 693629 YIL048W NEO1
SGTC_2731 amoxapine 43.43 µM -0.321707655324345 0.40926380205343 no 2022 0.373837088908584 3027 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2677 mitomycin C 100 µM -0.325434168237017 0.408451659044223 no 2023 0.372426249571648 2992 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2288 7946289 167.31 µM -0.326824160943134 0.408148829416884 no 2024 0.371900442134011 3178 1246052
SGTC_612 0302-0167 22.4 µM -0.330416464358027 0.407366449651918 no 2025 0.370542651359094 3056 235821
SGTC_277 nystatin 15.5 µM -0.332851177528623 0.406836395159117 no 2026 0.369623312311307 2939 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1839 st053978 48 µM -0.335360998053319 0.4062901678498 no 2027 0.368676392587977 3087 3788398
SGTC_3177 9107506 49.47 µM -0.335575668484582 0.406243456284432 no 2028 0.368595437386135 3099 8897194
SGTC_214 4373-3496 70 µM -0.336240033524347 0.406098901139743 no 2029 0.368344933066259 3047 3779166
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.337539610766035 0.405816171064286 no 2030 0.367855078609413 3139 16725076
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.337933023730027 0.405730591619834 no 2031 0.367706830333204 3005 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2207 7258803 200 µM -0.338795124931399 0.405543073798032 no 2032 0.367382037032315 3083 3666799
SGTC_1938 st074717 56.4 µM -0.338822175499382 0.405537190310809 no 2033 0.367371847368871 2938 17250979
SGTC_988 1497-1057 103 µM -0.339213352412867 0.405452111882203 no 2034 0.367224505597897 3074 3533044
SGTC_1015 4130-4525 82 µM -0.340091460496487 0.40526114537233 no 2035 0.366893826223704 3020 1363237
SGTC_856 0433-0016 11.3 µM -0.341119405683501 0.405037621702775 no 2036 0.366506846413397 3094 3911780
SGTC_1788 fluconazole 20 µM -0.345093232676989 0.404173816625068 no 2037 0.365012140428724 3112 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1468 k284-1086 134 µM -0.345392009664264 0.404108889219825 no 2038 0.364899841686345 3036 15996457
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.347273001473422 0.403700190499039 no 2039 0.36419311591823 2934 4000243
SGTC_3243 9134147 49.47 µM -0.349502000416502 0.403216013503856 no 2040 0.363356234639745 3095 24282180
SGTC_1180 1193-0155 285 µM -0.350040565631621 0.403099050077092 no 2041 0.363154127070762 3157 2921347
SGTC_250 brefeldin a 552.239 µM -0.351976212303026 0.402678745763419 no 2042 0.362428051114651 2994 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1570 verbenone 133 µM -0.353958697689522 0.402248387508832 no 2043 0.361684918218103 3213 29025 A natural terpanoid with antifungal properties.
SGTC_1329 1447-1697 50.6 µM -0.355302569523981 0.401956726925305 no 2044 0.361181465343007 3122 2840515
SGTC_567 1080-0542 68.4 µM -0.356476355015634 0.401702024847769 no 2045 0.36074192828599 3096 5950415
SGTC_2935 9038016 29.96 µM -0.358334345745669 0.401298941083473 no 2046 0.360046559050042 3206 6463195
SGTC_596 1155-0152 116 µM -0.358672740266246 0.401225539019161 no 2047 0.359919961709474 3061 280313
SGTC_1967 st070177 51.4 µM -0.361196893019068 0.400678128414783 no 2048 0.358976132298063 3190 5729214
SGTC_1662 st014054 52 µM -0.363699017709925 0.40013568745355 no 2049 0.358041388474467 3072 2838777
SGTC_3016 9080866 49.47 µM -0.364487092547958 0.399964878860887 no 2050 0.357747155281758 3046 17066299
SGTC_2407 paclitaxel 400 µM -0.36681998868335 0.399459355541169 no 2051 0.356876648312051 3225 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2378 9074213 121.43 µM -0.368737270298982 0.399044019284806 no 2052 0.356161782813706 3063 657714
SGTC_12 0849-0099 9.267 µM -0.370331401503629 0.398698773331994 no 2053 0.355567789697629 3114 6071388
SGTC_1337 1486-1011 40.3 µM -0.372613970533227 0.398204568304261 no 2054 0.354717886756188 3121 X1337
SGTC_385 1494-0393 12.4 µM -0.373736413703757 0.397961605005953 no 2055 0.354300215543562 3100 3090647
SGTC_2661 dactinomycin 12.96 µM -0.373836126371768 0.397940023180624 no 2056 0.354263120027227 3086 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1255 0566-0045 221 µM -0.375893530052863 0.397494788198871 no 2057 0.353498025330004 3210 2788469
SGTC_2978 9011784 42.97 µM -0.378571027173871 0.396915561141121 no 2058 0.352503220226946 3155 2994934
SGTC_2806 7952793 58.44 µM -0.37937854273867 0.396740914624109 no 2059 0.352203391071703 3209 2972490
SGTC_1458 k015-0034 6.33 µM -0.38163038951223 0.396254002937997 no 2060 0.351367769864881 3124 3598957
SGTC_2862 9027634 71.43 µM -0.385263963403874 0.395468664996288 no 2061 0.350020928884131 3046 5012562
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.387096502639197 0.395072752173174 no 2062 0.349342383337188 3074 688803
SGTC_2457 5731572 11.68 µM -0.388785404227499 0.394707967583891 no 2063 0.348717449412895 3218 2865357
SGTC_881 0833-0569 170 µM -0.38920519765866 0.394617311024326 no 2064 0.348562179411154 3111 5418700
SGTC_1306 1185-0270 9.02 µM -0.389249253761172 0.394607797212248 no 2065 0.348545885745389 3192 1548076
SGTC_1900 st060200 72.8 µM -0.396081092164631 0.393133241724096 no 2066 0.346022603187558 3085 688945
SGTC_859 0439-0102 54.6 µM -0.398786713741752 0.39254969393946 no 2067 0.345025183821517 3237 610143
SGTC_2567 aureobasidin a 60 nM -0.399788549720016 0.392333679399238 no 2068 0.344656132506627 3306 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_67 0335-0847 266 µM -0.404059137488238 0.391413233787468 no 2069 0.343084616268608 3384 4552207 YOR254C SEC63
SGTC_1089 terbinafine 2.25 µM -0.408100905534719 0.390542665584947 no 2070 0.341599797626981 3221 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_268 camptothecin 39.6153 µM -0.409022545475423 0.390344227504158 no 2071 0.341261557958356 3224 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1275 0867-0008 21.1 µM -0.410188547562902 0.390093216800349 no 2072 0.340833820657121 3077 3422836
SGTC_1216 1165-0504 9.65 µM -0.411566050385656 0.389796734392507 no 2073 0.340328759808727 3245 6304004
SGTC_1676 st018489 23.4 µM -0.413004755016046 0.389487147857678 no 2074 0.339801564969529 3127 3696235
SGTC_1377 2944-0135 198 µM -0.423576530431353 0.387214431290252 no 2075 0.335937337254459 3197 1894137
SGTC_3221 9128209 49.47 µM -0.423872787348752 0.387150797334021 no 2076 0.335829295559985 3164 16460723
SGTC_2814 7977482 42.97 µM -0.424084118452882 0.38710540671375 no 2077 0.335752233681298 3281 6456762
SGTC_1806 st050005 60.3 µM -0.425025276896633 0.386903279334644 no 2078 0.335409124196344 3162 5194765
SGTC_9 0092-0002 10.449 µM -0.426228629739219 0.386644886600408 no 2079 0.334970628831666 3233 759368
SGTC_373 0844-0104 25.9 µM -0.426723120462689 0.386538720490765 no 2080 0.334790504199194 3283 5375804
SGTC_1336 1486-0901 104 µM -0.427597147688335 0.386351089473568 no 2081 0.334472221468981 3208 5006114
SGTC_1912 st060209 90.8 µM -0.427662490795677 0.38633706306712 no 2082 0.334448431124672 3196 688787
SGTC_994 3910-0338 138 µM -0.428101787718009 0.386242768421176 no 2083 0.334288507645959 3319 3479481
SGTC_1023 4482-3888 16 µM -0.429683036319751 0.385903410639806 no 2084 0.333713112451496 3306 3303168
SGTC_1441 4106-0040 13 µM -0.430373874413887 0.385755174632009 no 2085 0.333461848319615 3208 2904180
SGTC_2589 lobaric acid 100 µM -0.433721611221506 0.385037073463848 no 2086 0.332245305600948 3146 73157 A novel microtubule depolymerizer.
SGTC_130 0136-0219 337.655 µM -0.434370973463398 0.384897828568295 no 2087 0.332009536232351 3161 234244
SGTC_2155 5570423 76 µM -0.435515257470148 0.384652492094993 no 2088 0.331594233361018 3158 797402
SGTC_3289 9119912 71.43 µM -0.435788705130727 0.384593871276463 no 2089 0.331495019733957 3277 17014829
SGTC_1514 1189-1591 158 µM -0.437299102268246 0.384270124833307 no 2090 0.330947223161363 3336 767698 YMR146C TIF34
SGTC_3002 9075603 71.4286 µM -0.440001241868048 0.383691135574892 no 2091 0.329968103936977 3241 20105405
SGTC_869 0564-0080 44.1 µM -0.441684200813918 0.383330657931913 no 2092 0.329358872014861 3211 6843321
SGTC_2657 nystatin 74.44 µM -0.44239469803542 0.383178504858898 no 2093 0.329101807508901 3245 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2021 4019055 173 µM -0.442989590605679 0.383051122396154 no 2094 0.328886631976958 3332 44827708 YER133W GLC7
SGTC_318 1488-0629 67.2 µM -0.444067280979345 0.38282039218116 no 2095 0.328496970568531 3274 3662576
SGTC_1456 k015-0012 13 µM -0.444353589663342 0.382759101353926 no 2096 0.328393481027777 3361 2989616
SGTC_1681 tripelennamine 100 µM -0.444756377392525 0.382672880532469 no 2097 0.328247911097551 3269 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1127 asiatic acid 681.4 nM -0.445784599947163 0.382452805385088 no 2098 0.327876423513355 3156 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1521 st012942 49.4 µM -0.446081376504792 0.382389292005627 no 2099 0.327769232450818 3354 24207259
SGTC_1231 0242-0792 125 µM -0.447778972337494 0.382026049072864 no 2100 0.327156360274101 3163 3707635
SGTC_2065 5221596 34.26 µM -0.448397305549951 0.381893767052141 no 2101 0.326933243015895 3293 788581
SGTC_392 N-ethylmaleimide 8.33 µM -0.448542269263518 0.381862756491513 no 2102 0.326880943749149 3183 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_141 0443-0274 32.331 µM -0.449167290558151 0.381729060950531 no 2103 0.326655490713945 3357 1627241
SGTC_216 k038-0035 28.382 µM -0.449715780337089 0.381611747548664 no 2104 0.326457695691385 3262 4444231 YPR107C YTH1
SGTC_2925 9010536 32.5 µM -0.450393668446716 0.381466772889158 no 2105 0.326213304772869 3209 2994177
SGTC_133 0724-0033 378.92 µM -0.451496034827293 0.381231053877956 no 2106 0.325816041109358 3116 280309
SGTC_1523 st012844 44.7 µM -0.452976404577217 0.380914575723938 no 2107 0.325282866076805 3321 4274103
SGTC_2305 7443522 69.23 µM -0.454806640921302 0.380523412105326 no 2108 0.324624176095301 3213 5415886
SGTC_2797 7859098 81.82 µM -0.454922207183271 0.38049871703103 no 2109 0.32458260293781 3176 972681
SGTC_657 3534-0529 86.7 µM -0.455751968669257 0.380321421617386 no 2110 0.324284173413514 3313 1049549
SGTC_2290 7904846 200 µM -0.456577920772663 0.38014496512244 no 2111 0.323987226018623 3258 2962154
SGTC_2697 mebhydrolin 72.4 µM -0.461753299728318 0.379039865803946 no 2112 0.322129122002133 3366 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_68 0986-0284 82.829 µM -0.46186786287657 0.379015414264277 no 2113 0.322088040697457 3326 423278 YIL048W NEO1
SGTC_2706 st078239 82.5 µM -0.466423829419591 0.378043414721997 no 2114 0.320456078966565 3302 15434492
SGTC_3320 9137005 35.139 µM -0.466497044900058 0.378027800737387 no 2115 0.32042988116029 3255 4908713
SGTC_1769 st044406 64.4 µM -0.467660836234761 0.377779636551639 no 2116 0.320013576061994 3194 670903
SGTC_1035 k081-0041 55.2 µM -0.468483866691286 0.3776041658712 no 2117 0.319719302802902 3361 731709
SGTC_1230 0170-0365 3.77 µM -0.468890074533134 0.377517571376691 no 2118 0.319574105623359 3403 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1115 galangin 695.678 nM -0.469398144486085 0.37740927080779 no 2119 0.319392537212609 3378 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3316 9136639 10.545 µM -0.470714854847326 0.377128644729505 no 2120 0.318922187443039 3317 4903665
SGTC_1746 st038117 42 µM -0.470740738382672 0.37712312890791 no 2121 0.318912944353429 3295 2898218
SGTC_1021 4476-0760 85.3 µM -0.475801410129972 0.376045174872652 no 2122 0.317107932579495 3229 746768
SGTC_586 0957-0265 8.15 µM -0.477586899552974 0.375665084900067 no 2123 0.316472128446637 3290 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1445 4239-0156 97.7 µM -0.47796227718939 0.375585190897488 no 2124 0.316338527181143 3398 4008346
SGTC_2402 5553605 200 µM -0.478801550769901 0.375406582281969 no 2125 0.316039906677418 3414 6758546
SGTC_1166 k206-0078 225 µM -0.478995133531141 0.375365389076257 no 2126 0.315971045346733 3279 5404595
SGTC_58 0957-0393 9 µM -0.479199874234512 0.375321823076301 no 2127 0.315898221856349 3358 6997992
SGTC_1342 1486-1464 234 µM -0.481453327962746 0.374842424360901 no 2128 0.315097171516943 3246 3253938
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.483340629417585 0.374441069439251 no 2129 0.314426948031924 3444 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_473 2-arachidonoylglycerol 10 µM -0.484611414108642 0.374170900022783 no 2130 0.313976007768974 3206 5282280 An endocannabinoid.
SGTC_1545 lovastatin 49.4 µM -0.484802706011591 0.374130236622497 no 2131 0.313908151515534 3318 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2582 agaric acid 100 µM -0.485056920411386 0.374076199796261 no 2132 0.313817984740857 3344 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.485479543496792 0.373986370824785 no 2133 0.313668110048091 3276 688761
SGTC_1483 3453-0561 55.9 µM -0.486383586070653 0.373794238626456 no 2134 0.313347612972365 3340 4546991
SGTC_1760 st045453 10.4495 µM -0.490077145631424 0.373009588861022 no 2135 0.312039654854579 3370 3323419 YIL048W NEO1
SGTC_1133 3473-0247 50 µM -0.490379791758981 0.37294531883274 no 2136 0.311932586900763 3250 711311
SGTC_2702 st077768 96.8 µM -0.49199355944139 0.372602678348956 no 2137 0.311361948286964 3312 6484119
SGTC_916 4466-0038 42 nM -0.493931028455421 0.372191441693278 no 2138 0.310677445165376 3454 5722064 YGL116W CDC20
SGTC_296 1222-0039 74.9 µM -0.493961245586793 0.372185029121872 no 2139 0.310666774706173 3293 5984176
SGTC_445 e6 berbamine 66 µM -0.494057438778532 0.372164615583233 no 2140 0.310632807435469 3350 6610268 A calcium/calmodulin antagonist.
SGTC_623 k072-0108 16.9 µM -0.496640480642648 0.371616592543685 no 2141 0.309721300720002 3324 5382803
SGTC_3251 9135047 49.47 µM -0.499022022975535 0.371111550432741 no 2142 0.308881934667748 3340 17682963
SGTC_2625 euphol 100 µM -0.499332248165755 0.371045778800818 no 2143 0.308772670226424 3385 6708538 A triterpene alcohol.
SGTC_1524 corynanthine 62.1 µM -0.501802421308791 0.370522205660081 no 2144 0.307903254877064 3395 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_801 0866-0028 10.1 µM -0.503122970219866 0.370242402929684 no 2145 0.307438908951807 3270 6849771
SGTC_1754 st042065 16.137 µM -0.503298368792922 0.370205244000272 no 2146 0.307377256566411 3354 1126236 YIL048W NEO1
SGTC_1825 st052143 62.6 µM -0.504110483119131 0.370033209939936 no 2147 0.30709187032437 3413 674173
SGTC_159 3970-0959 50 µM -0.506247561362229 0.369580626756296 no 2148 0.306341435149831 3449 6615653
SGTC_2228 7354201 200 µM -0.507445370156317 0.369327037826497 no 2149 0.305921179206686 3317 753451
SGTC_1834 st055981 52.8 µM -0.507588724996267 0.369296691880783 no 2150 0.305870899696382 3429 471719 YDL150W RPC53
SGTC_710 3448-4187 58 µM -0.507738614464768 0.369264963528798 no 2151 0.305818332177822 3382 3946412
SGTC_2502 avocadyne acetate 18.59 µM -0.509322715942969 0.368929698055673 no 2152 0.30526301896311 3268 3952079
SGTC_1155 4088-0394 48.2 µM -0.509952524724839 0.368796430532383 no 2153 0.305042361302166 3267 2326248
SGTC_841 0251-0215 91.2 µM -0.51172069157453 0.368422370827371 no 2154 0.304423251303233 3354 3888614
SGTC_2097 5376186 200 µM -0.512258984882703 0.368308518395369 no 2155 0.304234883160373 3379 742755
SGTC_174 3553-0389 74.3 µM -0.512459916842688 0.368266022980848 no 2156 0.304164583166946 3411 738071
SGTC_177 1327-0068 8.361 µM -0.51268833199835 0.368217717059637 no 2157 0.304084676428912 3381 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_808 0711-0032 135 µM -0.513274825925511 0.368093693111302 no 2158 0.303879545445264 3377 4252555
SGTC_1777 st045864 34.765 µM -0.514611768952161 0.36781102555659 no 2159 0.303412169704208 3389 4691462
SGTC_2757 clomiphene 4.22 µM -0.51757663146026 0.367184425368344 no 2160 0.302376844850197 3498 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2863 9028737 58.44 µM -0.51954566659596 0.366768480669 no 2161 0.301690138035805 3315 6460917
SGTC_3324 9138759 60.749 µM -0.519834841512104 0.366707407678889 no 2162 0.301589346514771 3409 45595710
SGTC_3138 9097216 49.47 µM -0.520647423003739 0.366535810648742 no 2163 0.30130620346803 3410 25237486
SGTC_2154 5570129 200 µM -0.524323893462741 0.365759765228849 no 2164 0.300026640480863 3413 673366
SGTC_2815 7968870 71.43 µM -0.525316145798224 0.365550410231763 no 2165 0.299681717600814 3362 2977326 YHR190W ERG9
SGTC_1188 1403-0014 4.57 µM -0.527174516672739 0.365158420943859 no 2166 0.299036201729629 3343 9614867
SGTC_2488 5268135 45.7 µM -0.530788217716041 0.364396580472937 no 2167 0.297782772851433 3405 1270356 YLR208W SEC13
SGTC_2648 atorvastatin 78.68 µM -0.531648828479702 0.36421522532889 no 2168 0.297484619721761 3435 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2178 5812956 200 µM -0.533090031940181 0.363911590901255 no 2169 0.296985629460201 3386 5403383
SGTC_3191 9110352 49.47 µM -0.533855182410758 0.363750422810922 no 2170 0.296720865835389 3406 17122424
SGTC_3038 9091290 49.47 µM -0.53446663057344 0.363621647257156 no 2171 0.29650936526414 3445 25236843
SGTC_62 0180-0423 3.232 µM -0.534789582446457 0.363553637395194 no 2172 0.296397683753019 3374 30102 YGL099W LSG1
SGTC_2877 9040724 71.43 µM -0.536531435409771 0.363186897855985 no 2173 0.295795658114524 3457 6463895
SGTC_2595 hexamethylquercetagetin 100 µM -0.540588862839713 0.362333110965973 no 2174 0.294395498000099 3343 386331
SGTC_3332 9141069 11.198 µM -0.541164016763 0.362212139097038 no 2175 0.294197268491625 3329 17332883
SGTC_2448 5185112 27.17 µM -0.541444591048474 0.362153131025186 no 2176 0.294100589627011 3414 5718189
SGTC_1748 st037455 53.6035 µM -0.541712038649752 0.362096886698888 no 2177 0.294008447559947 3466 580690
SGTC_3336 9143619 71.43 µM -0.545141889294915 0.36137585221357 no 2178 0.292827967241314 3466 45595730
SGTC_353 1988-1175 58.3 µM -0.545203885560254 0.361362823675035 no 2179 0.292806649729734 3297 2788357
SGTC_1767 st044992 70.3 µM -0.548100193212637 0.36075434296732 no 2180 0.291811553966427 3391 9600693
SGTC_3200 9114385 49.47 µM -0.55026888031524 0.360298957494423 no 2181 0.291067482755537 3455 17018030 YLR208W SEC13
SGTC_1020 4335-0961 93.3 µM -0.553235094039642 0.35967642661072 no 2182 0.290051219542689 3285 669075
SGTC_1351 1496-0003 46.5 µM -0.55352186030365 0.359616261555045 no 2183 0.289953057945874 3453 3891978
SGTC_789 1309-1135 70.6 µM -0.556056962048901 0.359084535495858 no 2184 0.2890859576189 3466 3092424
SGTC_795 0685-0265 78 µM -0.556398415563282 0.359012938003831 no 2185 0.288969260903828 3515 302754
SGTC_1252 0493-0875 34.8 µM -0.560415727283277 0.358170942703105 no 2186 0.287597953316595 3404 3960963
SGTC_1857 st056007 79.3 µM -0.56190397796129 0.357859192431162 no 2187 0.287090721626784 3465 619834
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.562432561919583 0.357748490474325 no 2188 0.286910669476785 3466 66535 A nucleotide analog.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.563403512799345 0.357545174274422 no 2189 0.286580072856847 3452 91467 include heat shock
SGTC_2385 9074692 200 µM -0.563524006551179 0.357519945814543 no 2190 0.286539058849058 3413 17046906
SGTC_2853 9015042 58.44 µM -0.563793445120163 0.357463534186799 no 2191 0.286447356655034 3359 6457456
SGTC_968 1309-0633 340 µM -0.563839766872835 0.357453836239855 no 2192 0.28643159265983 3453 3761976
SGTC_121 0557-0495 61.343 µM -0.566916245069991 0.356809949472997 no 2193 0.285385543299699 3461 3104427
SGTC_276 colchicine 750 µM -0.567529564115668 0.356681634496138 no 2194 0.285177223205545 3511 2833 A microtubule depolymerizer.
SGTC_2439 5492030 7.2 µM -0.57025093634132 0.356112480920425 no 2195 0.284253756518504 3437 5722370
SGTC_2383 9036125 200 µM -0.572576096145936 0.355626445851023 no 2196 0.283465874259933 3416 79580
SGTC_1211 1056-0033 32.3 µM -0.57357877028136 0.355416926256636 no 2197 0.283126440637677 3496 6741922
SGTC_2121 5257820 149.641 µM -0.573874272281195 0.355355186253312 no 2198 0.283026442055446 3515 791256
SGTC_1280 0880-0253 10.1 µM -0.576898346525787 0.354723576994116 no 2199 0.282004063817471 3430 6836607
SGTC_429 1112-0049 25.5 µM -0.579598663208968 0.354159925121264 no 2200 0.281092647362703 3341 2836170
SGTC_1675 st018485 24.5 µM -0.581827663566297 0.35369489423641 no 2201 0.280341384254501 3426 3323024
SGTC_2473 5854593 8.94 µM -0.58289464968541 0.353472368728487 no 2202 0.279982111299825 3441 2872951
SGTC_787 4152-0075 138 µM -0.583653254255745 0.353314188248593 no 2203 0.279726811675336 3436 9566539
SGTC_504 lovastatin 124 µM -0.585307499417732 0.352969341108303 no 2204 0.279170486581477 3438 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_692 k241-0027 77.8 µM -0.586011522878791 0.352822615627248 no 2205 0.278933885717613 3562 3600480
SGTC_1057 3448-5381 134 µM -0.587802530597372 0.352449450538207 no 2206 0.278332422632672 3492 5497911
SGTC_3052 9092717 49.47 µM -0.587831310137547 0.352443455340407 no 2207 0.27832276294008 3516 25237534
SGTC_1583 clindamycin 39.6 µM -0.5893254903894 0.35213224619914 no 2208 0.277821474257292 3430 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1841 st054148 70 µM -0.590297353102049 0.351929878927897 no 2209 0.277495656813263 3451 675442
SGTC_1240 0356-0016 42.1 µM -0.591648758563293 0.351648550624107 no 2210 0.277042908100684 3435 4305613
SGTC_1871 st057448 67.3 µM -0.59304130551411 0.351358742676714 no 2211 0.27657675469159 3609 691747
SGTC_1053 3366-3204 134 µM -0.594062746908009 0.351146221757402 no 2212 0.276235073035048 3455 3632071 YPR165W RHO1
SGTC_3127 9126946 49.47 µM -0.595283786218651 0.350892233607866 no 2213 0.275826896016745 3433 27243249
SGTC_2762 leflunomide 42.06 µM -0.59687564030982 0.350561212388412 no 2214 0.275295206024913 3503 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3030 9087619 49.47 µM -0.598040411570507 0.350319073600237 no 2215 0.274906484431962 3461 25236973
SGTC_675 1309-0189 238 µM -0.600592421028056 0.349788761162024 no 2216 0.274055743580462 3469 4246530
SGTC_541 4513-1321 94 µM -0.601715319341482 0.349555513484781 no 2217 0.273681825458944 3445 747515
SGTC_3109 9122853 49.47 µM -0.603312064976191 0.349223936366419 no 2218 0.273150554122004 3510 1234709
SGTC_1644 st010134 20.9 µM -0.603844883202881 0.349113317950503 no 2219 0.272973387917588 3511 3818134
SGTC_2541 muurolladie-3-one 83.07 µM -0.604395777686331 0.348998960200797 no 2220 0.27279027114285 3558 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_733 4069-0007 56.1 µM -0.604487708877884 0.348979877946115 no 2221 0.27275971924106 3555 5717425 YNL287W SEC21
SGTC_1283 0922-0125 16.4 µM -0.609719059004997 0.347894631601746 no 2222 0.271023963537378 3504 3360884
SGTC_224 benfluorex 43.875 µM -0.610120021661493 0.347811502940074 no 2223 0.270891152302058 3538 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1025 k007-0731 70 µM -0.61368493092116 0.347072738375268 no 2224 0.26971177402506 3481 6256118
SGTC_284 0988-0104 32.6 µM -0.616354768324632 0.346519841865224 no 2225 0.268830199601681 3549 4666532
SGTC_1460 k062-0059 9.15 µM -0.618468535288229 0.346082333684495 no 2226 0.268133266306632 3472 1373085
SGTC_648 0375-0473 33.3 µM -0.620822922094221 0.345595263702017 no 2227 0.267358069839739 3545 1713139
SGTC_1776 st049249 45.9 µM -0.622664995227333 0.345214358068797 no 2228 0.266752345181105 3519 1822314
SGTC_2764 methyldopa 94.69 µM -0.623839632253311 0.344971547326477 no 2229 0.26636645447941 3593 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1247 0448-0043 5.84 µM -0.625175298338512 0.344695527608858 no 2230 0.265928006127649 3553 3089013 YGL099W LSG1
SGTC_2972 9093619 59.92 µM -0.628387007924742 0.344032155990995 no 2231 0.264875222978579 3523 25236256
SGTC_484 loperamide 105 µM -0.634298831139198 0.342812337232353 no 2232 0.262942909593273 3527 3955 An opioid-receptor agonist.
SGTC_1037 k284-1091 78.7 µM -0.637035223694715 0.342248275792866 no 2233 0.262050950080447 3574 3334711
SGTC_1371 2421-0008 32.7 µM -0.638592475011942 0.341927431514545 no 2234 0.261544038939592 3563 2827552
SGTC_2674 ligustilide 100 µM -0.640498326460943 0.341534919617631 no 2235 0.260924338400362 3562 5319022 A signalling regulator.
SGTC_1381 2324-0066 62.1 µM -0.641327538123942 0.341364196153362 no 2236 0.260654950539691 3562 10885928
SGTC_2427 5545055 42.75 µM -0.642522496109605 0.341118227567045 no 2237 0.260266993786206 3590 5372858
SGTC_1315 1237-0019 3.69 µM -0.642967545175642 0.341026636496171 no 2238 0.260122579606649 3581 825140
SGTC_1660 st012960 28.1 µM -0.644745946319638 0.340660735200067 no 2239 0.259545917990279 3561 24207266
SGTC_827 3253-0474 693 µM -0.648508745486981 0.339887043717022 no 2240 0.258327978119227 3604 5402065
SGTC_734 2023-0417 80 µM -0.650863566783375 0.339403197545999 no 2241 0.257567280902268 3570 3935732
SGTC_1954 st077032 68.9 µM -0.651818936145049 0.339206972795307 no 2242 0.257258992176922 3541 698907
SGTC_1169 aniline yellow 25.8 µM -0.654100930407391 0.338738447098784 no 2243 0.256523391052577 3565 6051 A DNA damaging agent.
SGTC_2229 7354935 190 µM -0.654661137348932 0.338623466792971 no 2244 0.256342975927771 3555 318112
SGTC_577 r071-0003 38.6 µM -0.656525710348618 0.338240878786489 no 2245 0.255742965300743 3643 4568517 YMR134W ERG29
SGTC_370 0180-0345 38.7 µM -0.656988498130675 0.338145946134127 no 2246 0.255594156076754 3544 3989527
SGTC_2082 5219693 150 µM -0.657795862968875 0.337980354287518 no 2247 0.25533465655234 3612 2834649
SGTC_3309 9129340 25.759 µM -0.658022871976242 0.337933800014101 no 2248 0.255261717164375 3619 17158987
SGTC_547 1120-0019 610 nM -0.663464903435522 0.336818509197024 no 2249 0.253516425036532 3589 3676939
SGTC_328 k915-0120 63.5 µM -0.663742589738278 0.336761638476528 no 2250 0.253427537799393 3593 6624543
SGTC_278 4092-0821 23.9 µM -0.664618973616221 0.336582177756654 no 2251 0.253147115240263 3608 877900
SGTC_2192 5915882 198.485 µM -0.666585511575251 0.336179617207137 no 2252 0.252518463080309 3578 2876149
SGTC_1703 st026983 48.3 µM -0.66772842525845 0.335945743083409 no 2253 0.252153480959053 3638 1104023
SGTC_1029 k015-0030 64.7 µM -0.670832703513389 0.335310836159105 no 2254 0.251163555615759 3643 2208316
SGTC_3308 9128332 17.569 µM -0.671933789161579 0.3350857479048 no 2255 0.250812924179624 3645 17332805 YDL196W YDL196W
SGTC_765 1319-0117 244 µM -0.673398854784833 0.334786345249579 no 2256 0.250346788503632 3617 3487746 YGL099W LSG1
SGTC_902 1120-0002 2.07 µM -0.673681705049624 0.334728553699818 no 2257 0.250256847776263 3629 3280475
SGTC_2138 5575593 77.673 µM -0.675242144758004 0.334409797356196 no 2258 0.249760967314934 3631 762213
SGTC_909 3448-9333 149 µM -0.676272757313951 0.334199336039417 no 2259 0.249433742973403 3599 3344074
SGTC_3184 9108758 49.47 µM -0.67701246833955 0.334048311826291 no 2260 0.249199021768986 3641 902885
SGTC_444 curcumin 90.4 µM -0.679476762114183 0.333545379556753 no 2261 0.248417913323087 3607 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1845 st056753 3.01 µM -0.683476524335957 0.332729713725072 no 2262 0.247152889673989 3602 5375839
SGTC_2025 5147754 141 µM -0.685453108534369 0.332326923531097 no 2263 0.246529020418855 3662 315777 YLR208W SEC13
SGTC_1658 st012944 20 µM -0.685741443629187 0.332268182501549 no 2264 0.246438083780707 3597 24207260
SGTC_2220 6782180 200 µM -0.686348809295134 0.332144460492847 no 2265 0.246246588430842 3591 833803
SGTC_1723 st034307 2.5525 µM -0.688412022432549 0.331724315159012 no 2266 0.245596677530422 3688 867466
SGTC_2409 alverine citrate 63.97 µM -0.691238736162526 0.331149036870272 no 2267 0.244707762319595 3759 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3005 9076496 71.4286 µM -0.69228289910613 0.330936634851677 no 2268 0.244379843603394 3674 21368410
SGTC_381 3461-2219 42.7 µM -0.692879117199998 0.330815377482628 no 2269 0.244192707952056 3649 2883159
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.692886829649494 0.330813809059884 no 2270 0.244190287743056 3648 6708760
SGTC_817 1391-0715 46 µM -0.694683710183394 0.330448472008349 no 2271 0.243626769447672 3640 1353946
SGTC_57 miconazole 162.5 nM -0.695033535277781 0.330377365258785 no 2272 0.243517142796715 3612 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2728 chlorpromazine 9.18 µM -0.695323950617911 0.330318339008987 no 2273 0.243426153959744 3673 2726 A thorazine and dopamine antagonist.
SGTC_2710 st078562 53.7235 µM -0.702143561972797 0.328933484979655 no 2274 0.241294818993449 3659 17250908
SGTC_462 ag-879 158 µM -0.702705320656933 0.328819513297383 no 2275 0.241119705590259 3678 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_521 r062-0005 13.8 µM -0.705292263232986 0.328294870364755 no 2276 0.240314187096714 3613 2832033
SGTC_2470 5664817 21.68 µM -0.707191724509948 0.32790986697686 no 2277 0.239723670287677 3707 2859561
SGTC_1101 ebselen 5.29 µM -0.711114658753608 0.327115303195743 no 2278 0.238506593474575 3753 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1665 st014639 11.4 µM -0.711985705210253 0.32693898472686 no 2279 0.238236813981498 3754 981133 YIL048W NEO1
SGTC_61 0978-8327 98.565 µM -0.713432853996399 0.326646136214797 no 2280 0.237788974570544 3699 6150059 YHR072W ERG7
SGTC_2945 9067681 61.76 µM -0.715845603482721 0.326158123905796 no 2281 0.237043344959942 3775 16456930
SGTC_2417 cerulenin 830 nM -0.719800512726074 0.325358832085943 no 2282 0.235823914598139 3758 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2433 5607874 27.82 µM -0.721071613389508 0.325102111405149 no 2283 0.235432727545074 3708 2252428
SGTC_3340 9146634 11.102 µM -0.722495045201561 0.324814723346438 no 2284 0.234995085274382 3718 4907387
SGTC_3036 9090181 49.47 µM -0.722659677880767 0.324781491057245 no 2285 0.234944497028718 3728 25236586
SGTC_2002 4023503 131 µM -0.724076012756177 0.324495651314508 no 2286 0.234509535038981 3754 4736863 YCR052W RSC6
SGTC_3179 9107801 49.47 µM -0.730285040276212 0.323243788740589 no 2287 0.23260798524361 3730 4818259
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.730868637590541 0.323126226550445 no 2288 0.232429697030411 3760 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2890 9046729 58.44 µM -0.731709031666867 0.322956965223494 no 2289 0.232173091323202 3662 903329
SGTC_270 tamoxifen 5.46 µM -0.733389498587228 0.322618617240415 no 2290 0.231660451160448 3782 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_449 xestospongin c 11.1929 µM -0.735563104723204 0.322181197594255 no 2291 0.230998311475355 3725 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_170 4197-0004 226 µM -0.73581077174929 0.322131372334614 no 2292 0.230922932451557 3747 218692
SGTC_96 0929-0093 37.281 µM -0.737068886081385 0.3218783162643 no 2293 0.230540229561961 3698 6991579
SGTC_345 1362-0200 395 µM -0.7399202744592 0.32130509621041 no 2294 0.229674185753004 3734 1419823
SGTC_3118 9124250 49.47 µM -0.741319449455372 0.321023972882056 no 2295 0.229249885820361 3699 1504786
SGTC_2441 5730946 39.09 µM -0.743102859221458 0.32066579748601 no 2296 0.228709704361383 3794 1774275
SGTC_962 1254-0300 21.5 µM -0.743900480895706 0.320505659211548 no 2297 0.228468342216646 3711 7340576
SGTC_2216 7189485 200 µM -0.750412528690129 0.319199489297992 no 2298 0.226503143765803 3745 731273
SGTC_1943 st076331 65.2 µM -0.751225993730777 0.319036483697031 no 2299 0.226258329548787 3797 24208415
SGTC_2194 5927483 104.545 µM -0.751529436106681 0.318975687575457 no 2300 0.226167046148399 3782 760979
SGTC_2512 diallyl trisulfide 49.23 µM -0.753479920545294 0.318585015065709 no 2301 0.225580786484814 3780 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_211 3455-0679 143.504 µM -0.755060152006795 0.318268650209812 no 2302 0.225106445524793 3773 748649
SGTC_3333 9141820 12.094 µM -0.757020295143233 0.317876410565188 no 2303 0.224518851798898 3771 1939433
SGTC_1356 1502-0781 85.8 µM -0.757205266775196 0.31783940686605 no 2304 0.224463447673468 3737 567702
SGTC_2033 5192550 145 µM -0.757437184334194 0.317793014172876 no 2305 0.224393992906488 3767 182073
SGTC_3268 9137683 49.47 µM -0.757833609502241 0.317713720068522 no 2306 0.224275299582339 3780 1953228
SGTC_27 0485-0001 32.618 µM -0.758771741755289 0.317526105458514 no 2307 0.223994556231137 3693 2054479
SGTC_1556 plumbagin 1.48 µM -0.759540674958114 0.317372363464661 no 2308 0.223764595977122 3691 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2257 7960413 200 µM -0.762254469352641 0.316830014090998 no 2309 0.222954071241151 3756 2974689 YIL048W NEO1
SGTC_1879 gemcitabine 100 µM -0.762564028324239 0.316768173984407 no 2310 0.222861722124071 3769 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3296 9122258 64.045 µM -0.765558260180378 0.316170285490654 no 2311 0.2219695941442 3801 4730474
SGTC_503 tyrphostin 8 294 µM -0.765680559053788 0.316145875040926 no 2312 0.221933198730943 3735 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_927 2425-1185 123 µM -0.770424901062848 0.315199539495234 no 2313 0.220523943533343 3763 730375
SGTC_949 1165-0505 146 µM -0.770616123477196 0.315161422456886 no 2314 0.220467250702655 3825 6244267
SGTC_2868 9035608 32.47 µM -0.773239017375146 0.31463879052193 no 2315 0.21969046944243 3766 6462614
SGTC_2652 actinonin 100 µM -0.774456181100645 0.314396387228383 no 2316 0.219330535686003 3765 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2429 5902844 64.44 µM -0.776421960621531 0.314005062918758 no 2317 0.218749941130218 3837 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_489 paxilline 115 µM -0.778587299144271 0.313574254709691 no 2318 0.218111431566009 3744 105008 A toxic potassium channel blocker.
SGTC_1050 3232-1156 69.3 µM -0.779678201413608 0.313357308828499 no 2319 0.217790156413505 3788 700529
SGTC_546 peri-Naphthalide 147 µM -0.779933398173238 0.313306567598348 no 2320 0.217715039347474 3750 223824 A penicillin ester.
SGTC_157 1348-1695 65.819 µM -0.782167934619431 0.312862421735242 no 2321 0.217057943172486 3778 5380510
SGTC_2713 st079149 53.4 µM -0.782393190746612 0.312817663933876 no 2322 0.216991767154951 3840 3103253
SGTC_3246 9135460 32.98 µM -0.782933448867551 0.312710327309298 no 2323 0.216833096999559 3723 41446951
SGTC_37 0566-0070 1.56 µM -0.783945775966291 0.312509244406492 no 2324 0.216535964057541 3818 1626686
SGTC_1205 4161-2785 76 µM -0.785940255477666 0.312113235658964 no 2325 0.215951244681575 3908 3498106
SGTC_2087 5276107 200 µM -0.787549175205159 0.311793938852463 no 2326 0.215480226800106 3783 144405
SGTC_2368 9071271 200 µM -0.789749426249563 0.311357518841349 no 2327 0.214837059887497 3826 27209959
SGTC_2793 7325131 81.82 µM -0.789750657040975 0.311357274787852 no 2328 0.214836700420789 3816 4176441
SGTC_1190 1486-1332 13 µM -0.790565501060614 0.311195717655836 no 2329 0.214598792605139 3810 4150046
SGTC_2605 digitonin 300 nM -0.793158552115494 0.310681841876542 no 2330 0.213842726281072 3829 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1999 st074831 12.5 µM -0.794185970915583 0.310478336037748 no 2331 0.213543587224407 3804 17112523
SGTC_2572 astragaloside iv 100 µM -0.795354476182278 0.310246955005131 no 2332 0.213203666559146 3883 45006101 An anti-inflammatory agent.
SGTC_640 3381-0960 37.1 µM -0.79556753628478 0.310204774098776 no 2333 0.213141720954399 3861 1745025
SGTC_3300 9124615 50.48 µM -0.799375945560067 0.309451219967248 no 2334 0.212036227006329 3868 24824903
SGTC_2293 7624732 200 µM -0.799770492923003 0.309373198228626 no 2335 0.211921890948318 3753 894453
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.799920770214826 0.30934348315474 no 2336 0.211878351510279 3914 4213774
SGTC_2115 tiliquinol 12.7705 µM -0.800583436121988 0.309212465812765 no 2337 0.211686421514866 3832 71208 A bioactive hydroxyquinoline.
SGTC_90 0870-0863 4.608 µM -0.800659219280979 0.309197484079343 no 2338 0.211664478687765 3817 1738164
SGTC_834 0312-0008 75.7 µM -0.800691668300733 0.309191069260818 no 2339 0.211655083561067 3812 6385573 YIL048W NEO1
SGTC_1492 4158-0558 28.5 µM -0.802391705054681 0.30885507186608 no 2340 0.211163204913009 3834 3967268
SGTC_522 1273-0010 11.6 µM -0.804105504477784 0.308516516241723 no 2341 0.210668022932469 3954 5705015
SGTC_2856 9022925 19.48 µM -0.804338791585122 0.308470443693677 no 2342 0.210600670114029 3878 4944862
SGTC_1683 st010134 710 nM -0.805560104942761 0.308229292210022 no 2343 0.21024826841367 3844 3818134
SGTC_985 1493-0307 8.71 µM -0.806620106865491 0.308020059154833 no 2344 0.209942692932597 3843 3278274
SGTC_2743 auranofin 4.32 µM -0.807110679338354 0.307923246502952 no 2345 0.209801359961562 3797 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_796 1234-0020 70.7 µM -0.809925243967508 0.307368061165052 no 2346 0.208991571080606 3776 46495034
SGTC_459 nigericin 15.3 µM -0.810399877662251 0.307274480997211 no 2347 0.208855194080036 3871 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3208 9114115 49.47 µM -0.810677503935225 0.307219749204738 no 2348 0.208775447739933 3876 650895
SGTC_800 3448-7362 155 µM -0.811312855829137 0.307094510835041 no 2349 0.208593014576317 3926 15991913
SGTC_25 0118-0223 35.662 µM -0.811556009297185 0.307046587216299 no 2350 0.208523221043912 3852 5333628
SGTC_1212 0520-0165 585 µM -0.813478818955475 0.306667732839496 no 2351 0.2079717927008 3931 5403258
SGTC_863 0466-0191 129 µM -0.813948564016185 0.306575209556825 no 2352 0.207837208961632 3888 765160 YPR165W RHO1
SGTC_380 3970-0968 6 µM -0.816926143865999 0.305989017773156 no 2353 0.206985318099509 3783 2891601
SGTC_431 k089-0097 107 µM -0.817359458492596 0.305903753110633 no 2354 0.206861518469715 3767 5499420
SGTC_1721 st082152 9.2685 µM -0.818333832746021 0.305712060890984 no 2355 0.206583296190585 3799 5296051
SGTC_2827 7993847 71.43 µM -0.819065502885217 0.305568151729731 no 2356 0.206374521284065 3915 2985692
SGTC_888 0916-0002 6.97 µM -0.819127747374699 0.305555910505373 no 2357 0.206356766201171 3953 2802138 YIL048W NEO1
SGTC_3165 9101544 49.47 µM -0.820450294939717 0.305295864950852 no 2358 0.205979726853545 3873 5002184
SGTC_1036 k216-0215 33.5 µM -0.820720356180316 0.305242776306758 no 2359 0.205902786531895 3857 622330
SGTC_2337 9009472 200 µM -0.820761611297015 0.305234666735787 no 2360 0.205891034469691 3821 5742383
SGTC_1005 4092-0690 4.4 µM -0.822617963433181 0.304869860214622 no 2361 0.205362640061157 3897 1529343
SGTC_879 0831-1030 162 µM -0.825099008597392 0.304382593058547 no 2362 0.204657691265803 3908 1549252
SGTC_1663 st014140 55.4 µM -0.826692400464529 0.304069840336617 no 2363 0.204205714918891 3936 4207120
SGTC_2388 9080168 200 µM -0.827967162549221 0.303819731799828 no 2364 0.203844548443867 3843 15943073
SGTC_1246 0422-0085 105 µM -0.829219257148441 0.303574160010506 no 2365 0.203490175029541 3906 264295
SGTC_1476 4112-3294 3.34 µM -0.830546380641733 0.303313969697649 no 2366 0.203114968061155 3912 704369
SGTC_341 1486-1430 230 µM -0.830715095145224 0.303280899376099 no 2367 0.203067298373688 3850 2054753 YPL210C SRP72
SGTC_2796 7949634 45.45 µM -0.831955453365722 0.303037821910728 no 2368 0.202717044662054 3840 2971588
SGTC_89 0302-0250 142.109 µM -0.832295818755397 0.302971134525033 no 2369 0.202620995069778 3951 4203518 YLR208W SEC13
SGTC_1175 0741-0056 27.6 µM -0.832468355491146 0.302937332116417 no 2370 0.20257231636448 3963 765927
SGTC_287 k060-0039 29.6 µM -0.832756848588101 0.302880815973192 no 2371 0.202490937893684 3895 5861974
SGTC_2103 5378138 10 µM -0.833676040293257 0.302700776704737 no 2372 0.202231781598267 3909 244142
SGTC_1701 st028638 40.4 µM -0.834209556660447 0.302596300479424 no 2373 0.202081453396332 3834 3490878
SGTC_1262 0737-0114 49.6 µM -0.835858001161329 0.302273594807126 no 2374 0.201617396056382 3925 765919
SGTC_728 3030-5151 22.5 µM -0.83648876769113 0.302150154449111 no 2375 0.201439996549326 3911 3125388
SGTC_1098 clofazimine 15.1 µM -0.836639854463027 0.302120590283614 no 2376 0.201397518142875 3960 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2222 6885208 172.143 µM -0.83910474139023 0.301638452813747 no 2377 0.200705267831637 3831 609514
SGTC_92 0063-0024 660.874 µM -0.83924957168889 0.301610134445668 no 2378 0.200664637494022 3974 3594437
SGTC_456 gingerol 170 µM -0.842274476486257 0.301018954609911 no 2379 0.199817167136308 3909 442793 A herb.
SGTC_2513 baicalein 25.65 µM -0.844405958365062 0.300602697094266 no 2380 0.199221296979564 3902 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_453 enantio-paf c16 10 µM -0.846393647212563 0.300214755283398 no 2381 0.198666590634251 3799 13871343 A lipid and platelet activating factor
SGTC_810 3825-7150 143 µM -0.849187666425988 0.299669823181556 no 2382 0.197888437533136 3941 22330411 YGL099W LSG1
SGTC_2134 5324836 1.464 µM -0.849858167269693 0.299539118612101 no 2383 0.197701972854678 3873 699272
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.851095038380435 0.299298076062727 no 2384 0.19735828068708 3903 442882
SGTC_125 0133-0007 11.75 µM -0.854726832550041 0.298590817796572 no 2385 0.196351196136691 3998 26541
SGTC_1399 3562-5772 25 µM -0.854864388627756 0.298564044970636 no 2386 0.196313113617212 3845 23847490
SGTC_149 3970-0822 46.1 µM -0.855176529804733 0.298503296333545 no 2387 0.196226713671399 3925 3114250 YBL034C STU1
SGTC_1574 spiramycin 23.7 µM -0.858645819415198 0.297828485213609 no 2388 0.195267975436099 3893 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2351 9026858 72.31 µM -0.86141398840655 0.297290548534386 no 2389 0.194505037235651 3842 1409300
SGTC_2711 st079103 59.1 µM -0.868277221976785 0.295958739133596 no 2390 0.19262129432352 3902 54693780
SGTC_2897 9048598 12.99 µM -0.868356687530739 0.29594333490906 no 2391 0.192599549016959 3904 6467404
SGTC_2505 galangin 7.89 µM -0.871168532102766 0.295398502107018 no 2392 0.191831069533196 3835 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2377 9073351 62.6 µM -0.871178859575932 0.295396501870607 no 2393 0.19182825049065 3902 7337946 YHR072W ERG7
SGTC_1803 st050068 52.4 µM -0.871205860045267 0.295391272419321 no 2394 0.191820880417353 3994 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_298 1391-0729 10 µM -0.871297534954944 0.295373517139315 no 2395 0.191795858042087 3884 3237558
SGTC_2854 9024559 71.43 µM -0.871545142401515 0.295325563838176 no 2396 0.191728284365556 3989 3163529
SGTC_210 3551-0445 56.827 µM -0.872087586276625 0.295220523080654 no 2397 0.191580298879564 3966 2865180 YOR207C RET1
SGTC_2937 9044753 11.33 µM -0.875467934250142 0.294566328377171 no 2398 0.190659675063736 3915 6465530 YGL099W LSG1
SGTC_102 gallobenzophenone 83.616 µM -0.875600024139201 0.294540778763484 no 2399 0.190623756140696 3922 70837
SGTC_3218 9131285 49.47 µM -0.876207501084741 0.29442329011964 no 2400 0.190458619709612 3886 17156417
SGTC_1038 k292-0204 154 µM -0.878566390450244 0.293967276055163 no 2401 0.189818212866636 3887 4454212
SGTC_249 wiskostatin 11.211 µM -0.880100433721715 0.293670894350507 no 2402 0.189402452102118 3906 2775510 A n-wasp and actin depolymerizer.
SGTC_858 0438-0351 2.77 µM -0.881681571235762 0.293365558725544 no 2403 0.188974514764719 3935 2799119
SGTC_1872 amphotericin b 148 nM -0.881718213796218 0.293358484374997 no 2404 0.188964604465561 3966 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2294 7971431 200 µM -0.884710030189343 0.292781139962197 no 2405 0.188156522283837 3951 5741572
SGTC_2531 methyl deoxycholate 70.07 µM -0.886259308722642 0.292482376122875 no 2406 0.187738905371581 3909 16667744 Haematoxylin.
SGTC_3074 9116018 49.47 µM -0.887776696620667 0.292189899526366 no 2407 0.187330440210687 4004 17027303
SGTC_2534 helenine 20.12 µM -0.888787116271678 0.291995216594783 no 2408 0.18705875064694 3947 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_741 4582-0002 126 µM -0.889351332232795 0.291886532387278 no 2409 0.186907145941803 3919 2912688
SGTC_1783 st039459 87.517 µM -0.889545318165252 0.291849169475516 no 2410 0.186855039533139 4060 729761
SGTC_746 1095-0025 46.6 µM -0.889571486507484 0.291844129458615 no 2411 0.186848011163531 3980 6749286
SGTC_1596 piperlongumine 63 µM -0.89120105206489 0.291530355402675 no 2412 0.186410660057554 3994 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1914 st062367 72.6 µM -0.892199800192002 0.291338123503104 no 2413 0.186142924637263 3953 978205
SGTC_1906 st060206 94.7 µM -0.895006318432369 0.290798261833305 no 2414 0.185391855189988 3984 5133468
SGTC_2147 5545932 89.7195 µM -0.895688989498891 0.29066701402658 no 2415 0.185209446285524 3990 797404
SGTC_2100 5377183 190 µM -0.899036535049119 0.290023828743523 no 2416 0.184316600300325 4004 2844202
SGTC_1757 st041620 31.8375 µM -0.899142209914288 0.290003535625447 no 2417 0.184288458734693 4052 5289815
SGTC_840 0245-0196 390 µM -0.900878585850539 0.289670188586804 no 2418 0.183826439044473 4070 3827528
SGTC_2486 5283202 22.39 µM -0.903009114186505 0.289261418604765 no 2419 0.183260528877376 4027 1377751
SGTC_1977 st070720 65.3 µM -0.904785143448373 0.28892087129701 no 2420 0.182789611889141 4002 682188
SGTC_3291 9121177 71.43 µM -0.908275168215894 0.28825222162697 no 2421 0.181866429309052 3995 17015612
SGTC_2552 juarezic acid 87.02 µM -0.908553062876857 0.288199011507607 no 2422 0.181793046075188 3980 1549512
SGTC_955 1216-0110 33 µM -0.910676850163731 0.287792510608787 no 2423 0.181232832564742 3953 3619719
SGTC_2857 9024691 58.44 µM -0.911001474550751 0.287730400148259 no 2424 0.181147298367997 4070 16478292
SGTC_3192 9110362 49.47 µM -0.911882473713173 0.287561870296307 no 2425 0.180915294301286 4008 16649480
SGTC_1866 st057638 64 µM -0.912601495769147 0.287424360287417 no 2426 0.180726083683017 3957 688802
SGTC_1635 st007035 42.4 µM -0.913144497116126 0.287320534131595 no 2427 0.180583275163089 3962 3716403
SGTC_1179 1021-1431 9.29 µM -0.916078049144437 0.286759922886641 no 2428 0.179812979990951 4031 2840958
SGTC_809 3998-0021 90 µM -0.916623303709844 0.28665578015629 no 2429 0.179670034273234 3944 715485
SGTC_633 0437-0093 97.7 µM -0.917085699792276 0.286567477317337 no 2430 0.179548866974869 3933 2831118
SGTC_508 roscovitine 141 µM -0.917303688878251 0.286525852860936 no 2431 0.179491762447038 4056 160355 A CDKinase inhibitor.
SGTC_3322 9139058 2.11 µM -0.919773360938403 0.286054475768494 no 2432 0.178845603470095 4089 4908926 YPR165W RHO1
SGTC_847 0342-0274 5.54 µM -0.920019152563645 0.286007582607073 no 2433 0.178781375355946 4001 18097
SGTC_931 2812-0076 566 µM -0.920084109166261 0.285995190523211 no 2434 0.178764403891701 3970 3450959
SGTC_1911 st060208 74.3 µM -0.920248467611363 0.285963836210989 no 2435 0.178721465851494 4040 688783
SGTC_2936 9038235 15.59 µM -0.921482551620627 0.285728464826891 no 2436 0.178399273383161 3938 4749415
SGTC_1951 sophoraflavanone G 9.2 µM -0.922545980406625 0.285525715709642 no 2437 0.178121929004894 3967 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.92960530093097 0.284181552854395 no 2438 0.176287740909281 3998 6857784
SGTC_51 1013-0126 23.419 µM -0.930507475772597 0.284009988340939 no 2439 0.176054197642076 3989 1627850
SGTC_1168 k815-0004 80.5 µM -0.933367981811566 0.283466340389694 no 2440 0.175315002992882 3997 642433
SGTC_663 1486-0733 13.9 µM -0.933368460425256 0.283466249469444 no 2441 0.175314879477324 4010 722445 YPR165W RHO1
SGTC_544 k015-0020 52.4 µM -0.933792586687188 0.283385685463964 no 2442 0.175205447147327 4014 3008304
SGTC_520 3584-0023 682 µM -0.937371700405194 0.282706260064952 no 2443 0.17428369634226 4024 1340790
SGTC_91 0417-1751 58.384 µM -0.939489118299875 0.282304678151805 no 2444 0.173739838290236 4134 6795624
SGTC_1417 3966-0327 90.4 µM -0.939767012340549 0.282251994142609 no 2445 0.173668541528551 4102 651118
SGTC_2477 5967686 25.23 µM -0.941055179515283 0.282007841257054 no 2446 0.173338291299682 4011 776118
SGTC_2028 5153890 36.43 µM -0.941620862573361 0.281900656616969 no 2447 0.173193392323495 3990 2830968 YPR165W RHO1
SGTC_2693 st077581 40.7 µM -0.944482224721883 0.281358791645092 no 2448 0.172461640521468 4079 25238761
SGTC_2468 5987765 72.9 µM -0.944523797469362 0.2813509225922 no 2449 0.172451023448723 4076 26772094
SGTC_200 k038-0079 37.545 µM -0.944733697978018 0.281311193421899 no 2450 0.172397424289532 3989 3436683
SGTC_2641 levomentholum 100 µM -0.945783493050141 0.281112532855033 no 2451 0.172129513296336 4006 16666
SGTC_2834 9001755 58.44 µM -0.948892995380369 0.280524496455179 no 2452 0.171337518738052 3951 2989575
SGTC_2331 7980721 200 µM -0.949536000903506 0.280402972330225 no 2453 0.171174035462127 4002 2981221
SGTC_536 3852-0578 10.6 µM -0.952527640341663 0.279837906117583 no 2454 0.170414727461929 4096 2869208
SGTC_1966 st070145 16.1 µM -0.952585714229503 0.279826942485105 no 2455 0.170400009105033 3979 3748532
SGTC_1812 st052057 4.327 µM -0.954759958078492 0.279416622109252 no 2456 0.169849550511516 4054 3645418
SGTC_2992 9074591 71.4286 µM -0.954855804251124 0.27939854087592 no 2457 0.169825311170872 3988 17741321
SGTC_2116 5511452 16.8835 µM -0.955462318335834 0.279284136104438 no 2458 0.169671976181606 4078 870744
SGTC_642 0335-0876 158 µM -0.957964242704964 0.278812447052782 no 2459 0.169040394829848 4068 6812350
SGTC_1802 st050112 57.9 µM -0.959173426721832 0.278584618038932 no 2460 0.168735692478988 4036 4662563
SGTC_306 1672-3436 11.6 µM -0.960503538969991 0.278334109043412 no 2461 0.168400925361239 4093 6797378
SGTC_635 k038-0028 24.7 µM -0.960946800260082 0.278250651059154 no 2462 0.168289458821238 4046 4035102
SGTC_162 k030-0015 37.8 µM -0.961395586583886 0.278166165244227 no 2463 0.168176651266036 4121 1809920 YMR134W ERG29
SGTC_890 0929-0006 47.2 µM -0.961672116369925 0.278114113639389 no 2464 0.168107166583493 4026 1378169
SGTC_255 tunicamycin 200.472 nM -0.961684943499871 0.278111699285321 no 2465 0.168103943910541 3987 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1082 camptothecin 424.86 nM -0.962183046945094 0.278017952932556 no 2466 0.167978831735248 3955 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2884 9058502 51.95 µM -0.963175293188262 0.277831251609074 no 2467 0.167729780864191 4095 6471554
SGTC_1591 genipin 88.4 µM -0.963815100797835 0.277710897703858 no 2468 0.167569317205813 4092 442424 A DNA cross-linking agent.
SGTC_1896 st058441 89 µM -0.963925079170817 0.277690212289398 no 2469 0.167541744608494 4054 688759
SGTC_2903 5923464 63.88 µM -0.967083617426148 0.277096456212596 no 2470 0.166751117263863 4063 2876576
SGTC_641 4092-0595 30 µM -0.967320139713131 0.277052018716967 no 2471 0.16669200938853 4084 786260
SGTC_3117 9124945 49.47 µM -0.969965435744683 0.276555261769618 no 2472 0.16603186057615 3956 17592065
SGTC_1129 3453-1384 223 µM -0.970035998908183 0.276542016779614 no 2473 0.166014274296796 4176 1084452
SGTC_2969 9091408 28.7 µM -0.972637079474755 0.276054000606464 no 2474 0.165366853570997 4007 4286311
SGTC_480 am 92016 50 µM -0.978354352900681 0.274982811098416 no 2475 0.163949548157637 4036 2129 K+ channel blocker.
SGTC_2009 4012297 12.05 µM -0.978423202053578 0.274969923996623 no 2476 0.163932528702861 4071 45595307
SGTC_1348 1493-0373 93.8 µM -0.979425107826641 0.274782422156382 no 2477 0.163684988141503 4056 3010129
SGTC_2145 5634607 200 µM -0.979971478164952 0.274680198144967 no 2478 0.163550098885652 4024 308662
SGTC_3093 9117344 49.47 µM -0.980085604676591 0.27465884783517 no 2479 0.163521932167317 4098 24824913
SGTC_1244 0416-0015 52.5 µM -0.980494137188242 0.274582427993224 no 2480 0.163421131109478 4040 96201
SGTC_3223 9129970 49.47 µM -0.983027845730158 0.274108708407069 no 2481 0.162796867038049 4096 17248386
SGTC_113 0099-0221 2.5 µM -0.983247825408411 0.274067598550043 no 2482 0.162742740931233 3993 89219
SGTC_1692 fluoroquinolonic acid 71 µM -0.990698715995771 0.272676976046638 no 2483 0.160916359123329 4124 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2241 6772625 37.8075 µM -0.99281311274453 0.272282987174706 no 2484 0.160400519250928 3946 2285411
SGTC_256 clotrimazole 625 nM -0.994403162095703 0.2719868897128 no 2485 0.160013314651785 4020 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3071 9117417 49.47 µM -0.995862243860629 0.271715321880912 no 2486 0.159658541169986 4031 45595590 YGL055W OLE1
SGTC_2022 5136654 200 µM -0.995997765409774 0.2716901051338 no 2487 0.159625615458994 4142 1713771
SGTC_424 splitomicin 100 mM -0.997106985899431 0.271483754210646 no 2488 0.159356291238692 4152 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3010 9080089 71.4286 µM -0.997364570922302 0.271435846228752 no 2489 0.159293790916024 4104 17027233
SGTC_172 1112-0046 2.638 µM -0.998585536687469 0.271208817335578 no 2490 0.158997754700111 4071 2802135 YIL048W NEO1
SGTC_229 benomyl 22.8748 µM -0.999699047398398 0.271001851426342 no 2491 0.158728086608455 4108 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_952 1185-0122 232 µM -0.99989854857606 0.270964778883869 no 2492 0.15867980345124 4024 678600
SGTC_1836 st055642 81 µM -1.00049221525758 0.270854475039874 no 2493 0.158536181560793 4097 8571
SGTC_661 1304-0007 33.6 µM -1.00294199400235 0.270399540954054 no 2494 0.157944424677748 4090 3117130
SGTC_598 3937-0236 20.2 µM -1.00307357958474 0.270375115776844 no 2495 0.157912680586258 4162 1379313
SGTC_1910 st062352 60.4 µM -1.00315188011154 0.270360582000883 no 2496 0.157893793126001 4011 2245730
SGTC_2191 5911152 200 µM -1.00318188050789 0.270355013571719 no 2497 0.157886556897358 4097 2875902
SGTC_1792 st045773 43.6 µM -1.00532396041541 0.269957566396102 no 2498 0.157370440632442 4047 2919270
SGTC_2663 amphotericin b 100 µM -1.00827050254954 0.269411335367357 no 2499 0.156662309888685 4094 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1530 rhein 70.4 µM -1.0086832135894 0.269334871110662 no 2500 0.156563292411971 4147 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1992 st073643 23.3 µM -1.0098608150724 0.269116753066492 no 2501 0.156280989267 4070 3161292
SGTC_2816 7982706 58.44 µM -1.01281888865846 0.268569243147012 no 2502 0.155573338399511 4130 2981853
SGTC_2386 9075165 157.42 µM -1.01335226679439 0.26847057978329 no 2503 0.155445965258845 4077 16452277
SGTC_400 oxethazaine 37.5 µM -1.01376748169799 0.26839378666637 no 2504 0.155346857683104 4111 4621 A local anesthetic.
SGTC_3356 9151811 4.48 µM -1.01540728665767 0.268090616209915 no 2505 0.15495586053084 4100 1859254 YPR165W RHO1
SGTC_725 1497-0963 19 µM -1.01771146811487 0.267664905964731 no 2506 0.154407547818864 4216 3549977
SGTC_3097 9117246 49.47 µM -1.01772583208848 0.267662253210286 no 2507 0.154404133735371 4117 16423892
SGTC_1271 0832-2808 169 µM -1.01925559347405 0.267379811069441 no 2508 0.154040819962305 4145 3663794
SGTC_535 2293-4129 48.2 µM -1.0221758403875 0.266841059260588 no 2509 0.153348841628663 4123 396118 YIL048W NEO1
SGTC_2251 lansoprazole 556 µM -1.02451728314833 0.266409486682678 no 2510 0.152795505874505 4042 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_688 0527-0193 473 µM -1.02708482098436 0.26593664674847 no 2511 0.152190262735372 4167 4007154
SGTC_2847 9005661 71.43 µM -1.02722726329198 0.265910426907342 no 2512 0.152156731622229 4107 2991449
SGTC_1505 k297-0037 20.6 µM -1.0284882237239 0.265678374759154 no 2513 0.151860113758206 4125 4089396
SGTC_2346 9031566 143.75 µM -1.02872486669296 0.265634837249965 no 2514 0.151804490673919 4091 4771086
SGTC_2291 7917025 104.35 µM -1.02923326265415 0.265541314936838 no 2515 0.151685037660037 4044 2964612
SGTC_319 1348-1596 45.5 µM -1.02935929979802 0.265518132275104 no 2516 0.15165543356476 4220 5380505
SGTC_212 3807-4682 38.772 µM -1.03068074769956 0.265275133380255 no 2517 0.151345277949542 4183 3125501 YBL034C STU1
SGTC_2565 isoliquiritigenin 100 µM -1.0327238607736 0.264899651007187 no 2518 0.150866571965917 4223 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1835 st008666 49.2 µM -1.03313982867674 0.264823237727975 no 2519 0.150769233380616 4068 690455
SGTC_2839 9003951 25.97 µM -1.03415883634039 0.264636093440069 no 2520 0.15053095716932 4181 2990634
SGTC_439 amiodarone 34.4 µM -1.03455526683597 0.264563305785809 no 2521 0.1504383269952 3990 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2174 5790901 200 µM -1.03532597204563 0.264421827602068 no 2522 0.150258352278532 4137 786020
SGTC_3231 9132313 49.47 µM -1.03552986256558 0.26438440590683 no 2523 0.150210763872356 4089 4905967
SGTC_1670 st016595 4.04 µM -1.03877075261983 0.263789941049973 no 2524 0.149455683347643 4140 597879
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.03883622573061 0.263777938579536 no 2525 0.149440455213338 4151 5379071
SGTC_2111 5486399 200 µM -1.0402595277186 0.263517089017555 no 2526 0.149109670955314 4107 689674
SGTC_1307 1187-1599 12.2 µM -1.04230024740361 0.263143314708321 no 2527 0.148636248850043 4110 1538471
SGTC_107 0358-0022 2.6945 µM -1.04371609238051 0.262884150503972 no 2528 0.148308381127676 4173 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1191 1487-1166 10.6 µM -1.04649600544421 0.262375679587993 no 2529 0.147666044117512 4183 3955771
SGTC_1234 0326-0494 15.5 µM -1.05003863262347 0.261728432091015 no 2530 0.146850175605836 4226 1547813
SGTC_1221 2958-7315 257 µM -1.05326692374747 0.261139328851524 no 2531 0.146109336891368 4181 4562705
SGTC_2792 7535235 81.82 µM -1.05517255598012 0.260791906470194 no 2532 0.145673206628468 4156 1281891
SGTC_3257 9139206 32.98 µM -1.05603932569843 0.260633961412589 no 2533 0.145475124278489 4146 4910041
SGTC_1385 3091-4834 14.1 µM -1.05633182802173 0.2605806719836 no 2534 0.145408319802083 4122 4072814
SGTC_20 0481-0013 4.944 µM -1.05659953202386 0.260531905344132 no 2535 0.14534719709097 4175 182045
SGTC_516 3992-2719 87.3 µM -1.06094991034687 0.25974007232816 no 2536 0.144356332686284 4073 5350887 YDR037W KRS1
SGTC_120 rhodamine 6G 52.259 µM -1.06526236117174 0.258956370275243 no 2537 0.143378610175881 4173 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_829 1635-0120 117 µM -1.06555620769901 0.258903014066536 no 2538 0.143312152146549 4169 285054
SGTC_1609 st001574 46.4 µM -1.06822228786862 0.258419171281675 no 2539 0.142710126681216 4140 3960012
SGTC_237 nikkomycin 200 µM -1.06862760806538 0.258345654427223 no 2540 0.14261875159176 4172 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_693 4161-2696 114 µM -1.06975271405404 0.258141639853262 no 2541 0.142365315877948 4192 805759
SGTC_2656 pseudo-anisatin 100 µM -1.07350029253887 0.257462697423725 no 2542 0.141523353740905 4193 6708809 A neurotoxin.
SGTC_2777 climbazole 1.536 µM -1.07359330091524 0.257445859059338 no 2543 0.141502500702551 4019 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2598 perillyl alcohol 100 µM -1.07776480583563 0.256691232767142 no 2544 0.140569364653043 4211 10819 An apoptosis inducer.
SGTC_3354 9151612 71.43 µM -1.07788973136953 0.256668651481238 no 2545 0.140541484265467 4184 27261949
SGTC_2455 5377712 9.75 µM -1.07965218597537 0.256350184033156 no 2546 0.140148546643652 4171 2243908
SGTC_2043 5101342 149 µM -1.08044532666124 0.25620693437738 no 2547 0.139971960393097 4180 678451
SGTC_705 1124-0212 310 µM -1.08081462638842 0.256140249156834 no 2548 0.139889790458353 4162 9554485
SGTC_2437 5741531 144.16 µM -1.08226087077068 0.255879184955532 no 2549 0.13956831380443 4198 2262990
SGTC_71 0417-1750 47.813 µM -1.08411528833666 0.255544643965044 no 2550 0.139156842522507 4178 6811472
SGTC_1027 k015-0025 8.67 µM -1.08656413088533 0.255103217736669 no 2551 0.138614742172765 4145 3598955
SGTC_2638 epoxomicin 18 µM -1.08700971880572 0.255022939354703 no 2552 0.138516257282518 4160 9915668 A protesome inhibitor.
SGTC_1781 st038725 66.3 µM -1.08720290579223 0.254988138347627 no 2553 0.138473573460976 4166 4270275 YIL048W NEO1
SGTC_1077 5-fluorocytosine 377 nM -1.08980737723644 0.254519207438318 no 2554 0.137899001797223 4240 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2754 granisetron 64.02 µM -1.0903156544804 0.254427745654418 no 2555 0.137787060850686 4196 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_797 k781-0471 270 µM -1.09547017780643 0.253501190530564 no 2556 0.136655351868497 4161 23738129
SGTC_584 0986-0246 15.4 µM -1.09608312069602 0.253391128600121 no 2557 0.136521200335596 4281 53315 YDR232W HEM1
SGTC_499 genistein 192 µM -1.09727707423969 0.253176810722616 no 2558 0.136260144778843 4276 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2926 9010726 65.15 µM -1.09728046331429 0.253176202510311 no 2559 0.136259404250948 4227 2994293
SGTC_294 k038-0071 157 µM -1.09798922703611 0.253049022781711 no 2560 0.136104596727686 4185 24152826
SGTC_482 fipronil 114 µM -1.09878950318189 0.252905462582833 no 2561 0.135929945897627 4288 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_652 0437-0092 114 µM -1.09888086550459 0.252889075975265 no 2562 0.135910016911627 4124 3091274
SGTC_3150 9097574 49.47 µM -1.10005135230695 0.252679188690805 no 2563 0.135654874050487 4235 17217476
SGTC_2049 5262831 67.185 µM -1.10083480572997 0.252538754045597 no 2564 0.135484280197989 4189 763417
SGTC_1668 st014914 51.6 µM -1.10231160229685 0.252274148950484 no 2565 0.135163113510718 4197 2839556
SGTC_2244 6635614 200 µM -1.10556888401701 0.251691042530337 no 2566 0.13445658197929 4118 836499
SGTC_2628 lathosterol 100 µM -1.10815807026793 0.251228044351759 no 2567 0.133896777786047 4271 6710616
SGTC_1969 st069479 40.1 µM -1.10901176566384 0.251075485368423 no 2568 0.133712553186215 4196 3895485
SGTC_1097 itavastatin 7.23 µM -1.10929076217795 0.251025638137686 no 2569 0.133652384473677 4215 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2647 atorvastatin 60.16 µM -1.11344909726045 0.250283305518759 no 2570 0.132757799290399 4177 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3205 9113483 49.47 µM -1.11391055812867 0.250200998816077 no 2571 0.132658779736241 4241 17018033
SGTC_1060 3448-7350 82 µM -1.1143294992965 0.25012628841044 no 2572 0.132568928061844 4159 570178
SGTC_1891 st059073 26.2 µM -1.11497562835736 0.250011086451088 no 2573 0.132430432875354 4282 688754
SGTC_3145 9085516 49.47 µM -1.11510360358422 0.249988272373911 no 2574 0.132403013730153 4227 25236195
SGTC_1822 st052468 42 µM -1.1152153308011 0.249968355724306 no 2575 0.132379078977584 4198 2873678
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.11522243680849 0.249967089025992 no 2576 0.132377556794679 4199 688662
SGTC_2280 7785178 200 µM -1.11601056823866 0.249826619919027 no 2577 0.132208805458423 4195 2954328
SGTC_2360 9040895 200 µM -1.11602835726935 0.249823449853794 no 2578 0.132204998259377 4229 4914414
SGTC_1293 1000-1278 195 µM -1.11844187547232 0.249393550844853 no 2579 0.131689159016757 4251 678847
SGTC_731 3966-0296 387 µM -1.11899270957802 0.249295490696829 no 2580 0.131571624627544 4206 660956
SGTC_1284 0929-0043 16 µM -1.12035973899357 0.249052219074528 no 2581 0.13128024720318 4218 1239883
SGTC_2311 7694451 200 µM -1.12066705323442 0.24899754793422 no 2582 0.131214805668595 4192 2163142
SGTC_615 k087-0205 167 µM -1.12237876980303 0.248693150789693 no 2583 0.130850713638717 4230 9642773
SGTC_1103 duloxetine 36.1 µM -1.12449237004742 0.248317559671022 no 2584 0.130402102781116 4290 60835 A selective serotonin reuptake inhibitor.
SGTC_339 3091-4833 71.4 µM -1.12580867086024 0.248083803203532 no 2585 0.130123256600428 4080 3240077
SGTC_2418 pentamidine 31.67 µM -1.12600288540636 0.24804932337863 no 2586 0.130082149000708 4164 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2726 cimetidine 79.27 µM -1.12694670657509 0.247881798761137 no 2587 0.129882507062699 4205 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1424 4048-1941 275 µM -1.12746645664164 0.247789570920099 no 2588 0.129772657459589 4286 X1424
SGTC_2261 9010538 184.68 µM -1.12813577305636 0.247670830043156 no 2589 0.129631291680454 4225 6457250
SGTC_3089 9117425 49.47 µM -1.12900183446267 0.247517230498706 no 2590 0.129448529907625 4220 9401657
SGTC_887 0885-0007 9.62 µM -1.13119503722374 0.247128484742313 no 2591 0.128986505145443 4287 5719458
SGTC_1183 1254-0324 198 µM -1.13418423393734 0.246599175157692 no 2592 0.128358637970327 4305 5799357
SGTC_2474 5321570 43.32 µM -1.13420759260406 0.246595041333289 no 2593 0.12835373995855 4214 2841384
SGTC_2822 7994718 71.43 µM -1.13557737740458 0.246352693027868 no 2594 0.128066740611801 4196 1018011
SGTC_2908 7930301 100 µM -1.13639358011696 0.246208347602983 no 2595 0.127895940708187 4203 2223178
SGTC_602 3130-1533 38.1 µM -1.14011877271106 0.245550123645969 no 2596 0.127118410956817 4273 720941
SGTC_2930 9013230 14.89 µM -1.140792435192 0.245431191675571 no 2597 0.126978154694354 4252 2995857
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.14107576553162 0.24538118027374 no 2598 0.126919197618464 4214 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1722 st034304 3.6505 µM -1.1438348592215 0.24489445169247 no 2599 0.126346065063619 4204 4036148 YLR033W RSC58
SGTC_626 0214-0009 33 µM -1.14519198509335 0.244655233426109 no 2600 0.126064818870795 4287 3437874
SGTC_2946 9065502 71.43 µM -1.14666452997219 0.244395812854475 no 2601 0.125760147689042 4062 16489101
SGTC_2561 acetosyringone 100 µM -1.14675908767151 0.244379159540697 no 2602 0.125740601160477 4212 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2751 anetholtrithion 17.25 µM -1.14735845346812 0.244273614654316 no 2603 0.12561675233772 4223 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1344 1488-0097 29.1 µM -1.1482502800984 0.24411661458234 no 2604 0.125432629008952 4285 747966
SGTC_2715 st079500 56.4 µM -1.14926102860708 0.243938744921444 no 2605 0.125224181315975 4212 28246688
SGTC_2909 7941780 10.49 µM -1.15053365854829 0.243714889333784 no 2606 0.124962069708372 4226 1243215
SGTC_2105 5350118 200 µM -1.15229736511629 0.24340483681767 no 2607 0.12459944967478 4217 2133313
SGTC_2247 cerulenin 830 nM -1.1547331371658 0.242976988555537 no 2608 0.124099862613414 4305 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.15903680409463 0.242222036268976 no 2609 0.123220591729775 4262 5106787 A p450 inhibitor.
SGTC_301 4119-0100 24.5 µM -1.15937454556726 0.242162843276346 no 2610 0.123151773870131 4269 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1137 ixabepilone 100 µM -1.16313009945898 0.241505168937538 no 2611 0.122388360805098 4206 154225 A novel microtubule stabilizer.
SGTC_761 k216-0224 480 µM -1.16339540231194 0.241458745690666 no 2612 0.122334557044258 4296 1340404
SGTC_1121 fusaric acid 630.51 nM -1.16345326378507 0.241448621613216 no 2613 0.122322824868443 4207 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2623 humulene 100 µM -1.16351954428172 0.241437024734487 no 2614 0.122309386595219 4260 6187145 An anti-inflammatory.
SGTC_2320 7373003 200 µM -1.16478410146063 0.241215827321132 no 2615 0.122053197957095 4290 5415828
SGTC_1557 sumaresinolic acid 42.3 µM -1.16773734198802 0.240699673249674 no 2616 0.121456364628719 4238 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_555 4296-0685 37 µM -1.16941152492811 0.240407334293299 no 2617 0.121118934340852 4231 2908540 YHR072W ERG7
SGTC_1638 st008370 60.6 µM -1.17558978380487 0.239330187716917 no 2618 0.119879419969124 4214 24207134
SGTC_2156 5649887 115 µM -1.17729081371247 0.239034085708926 no 2619 0.119539726109398 4294 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1725 st036284 20.55 µM -1.18083602648416 0.238417606916478 no 2620 0.118833934619196 4320 707914
SGTC_1698 5-fluorocytosine 1.055 µM -1.18127718586806 0.238340954448957 no 2621 0.1187463136502 4277 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3162 9099653 49.47 µM -1.18134190673399 0.238329710183607 no 2622 0.118733462941044 4236 25237511
SGTC_608 k048-0125 159 µM -1.18241049335055 0.238144101529501 no 2623 0.118521430784551 4307 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1312 1218-2183 165 µM -1.18349978851782 0.237954977448747 no 2624 0.118305565142989 4326 6744073
SGTC_548 1436-0017 110 µM -1.18415027007147 0.237842079730146 no 2625 0.11817679183395 4328 9677137
SGTC_1145 3546-0597 10.2 µM -1.18541293719609 0.237623014828287 no 2626 0.117927109536926 4242 875334
SGTC_2149 5554786 194.827 µM -1.19119243342823 0.23662172271302 no 2627 0.116789024649835 4316 745063 YPR165W RHO1
SGTC_2130 NSC 7 2.4545 µM -1.19301622899698 0.236306234401792 no 2628 0.116431508604664 4349 21448
SGTC_3252 9135871 49.47 µM -1.19305887835542 0.236298859497582 no 2629 0.116423157411722 4290 17682838
SGTC_2217 6934799 96.0675 µM -1.19421976642276 0.236098168035763 no 2630 0.116196006491999 4252 675606
SGTC_518 1021-0119 62.6 µM -1.1942473057693 0.236093408242069 no 2631 0.11619062169096 4251 1097762
SGTC_2914 7968218 45.32 µM -1.19470542718612 0.23601423607064 no 2632 0.116101070643381 4242 2977111
SGTC_2072 5231554 129 µM -1.19474264512578 0.236007804739127 no 2633 0.11609379763801 4313 789545
SGTC_3343 9148379 18.9835 µM -1.19604543150072 0.235782741614782 no 2634 0.115839415234935 4311 1955036
SGTC_2107 5363541 170.161 µM -1.19735214675328 0.23555711868158 no 2635 0.115584663539317 4238 244052
SGTC_114 0364-0001 490.298 µM -1.198638822166 0.235335072346156 no 2636 0.115334207884632 4318 4003655
SGTC_73 0327-0325 16.231 µM -1.20227585741455 0.234708041069884 no 2637 0.114628333755549 4134 53298
SGTC_3106 9121286 49.47 µM -1.20486845524629 0.234261637168664 no 2638 0.11412704399387 4259 15943471
SGTC_645 0845-0943 5.41 µM -1.20845452310097 0.233644949007254 no 2639 0.113436239181572 4301 1885106
SGTC_509 pifithrin 175 µM -1.20860230868743 0.233619553972346 no 2640 0.113407834513953 4369 4817 A p53 inhibitor.
SGTC_123 0083-0120 66.675 µM -1.20866614756266 0.233608584563577 no 2641 0.113395566131108 4270 16001701
SGTC_472 calcifediol 10 µM -1.21003105747363 0.233374120973748 no 2642 0.113133487864244 4351 5283731 A vitamin D metabolite.
SGTC_145 3737-0113 38.366 µM -1.2103541486793 0.233318639633647 no 2643 0.113071513981241 4256 6849351
SGTC_2479 5617353 43.85 µM -1.21431916733452 0.232638361566358 no 2644 0.11231293454045 4317 2731746
SGTC_273 hydroxyurea 18.1 mM -1.21472167492474 0.232569365055815 no 2645 0.112236131402527 4362 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_160 3453-0671 289.699 µM -1.21594969329197 0.232358932558374 no 2646 0.11200204315982 4325 5322268
SGTC_2030 5175110 200 µM -1.21798860560203 0.23200977979218 no 2647 0.111614151389566 4302 2831986
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.21809987777466 0.231990733440808 no 2648 0.111593010167533 4204 6708630 An antioxidant.
SGTC_1319 1306-0155 43.7 µM -1.21900497031523 0.231835841961979 no 2649 0.1114211530067 4340 3122360
SGTC_532 1548-0774 215 µM -1.21910215795777 0.231819213344958 no 2650 0.111402710479846 4404 5932993
SGTC_1875 nocodazole 6 µM -1.22212612060481 0.231302151274352 no 2651 0.110829968338685 4325 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2393 9031399 185.94 µM -1.22615237887783 0.230614707987055 no 2652 0.110070668983077 4326 1526623 YDL150W RPC53
SGTC_124 0136-0217 7.121 µM -1.22781095323387 0.230331855372686 no 2653 0.109758971469114 4360 3976905
SGTC_362 0310-0100 9.03 µM -1.2310989646338 0.229771693106477 no 2654 0.109142926370734 4365 790235
SGTC_2950 9072895 21.46 µM -1.23165872988032 0.229676404713201 no 2655 0.109038296191126 4283 17332245
SGTC_2023 5144124 124 µM -1.23283926289473 0.229475516096785 no 2656 0.108817869753073 4298 2830192
SGTC_1832 st054113 55 µM -1.23391237932945 0.229292991781237 no 2657 0.108617778048615 4327 1251267
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.2353249698262 0.229052851112546 no 2658 0.108354792152438 4264 6708739 YPR165W RHO1
SGTC_2558 carylophyllene oxide 100 µM -1.23647762826236 0.228857003526956 no 2659 0.108140538260515 4432 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2073 5212005 126 µM -1.23724042957043 0.228727448057302 no 2660 0.107998918044507 4194 691789
SGTC_430 0958-0115 16.4 µM -1.23834082206364 0.228540628094148 no 2661 0.107794856653656 4260 6833180
SGTC_378 3970-0959 8.33 µM -1.2385938051572 0.228497689820355 no 2662 0.107747981700385 4338 6615653
SGTC_3124 9127567 49.47 µM -1.23927355267057 0.228382340194936 no 2663 0.107622104784423 4292 17592030
SGTC_3301 9125354 19.7965 µM -1.24039948060271 0.228191348076667 no 2664 0.107413836515233 4303 41905162
SGTC_2864 9034755 47.6 µM -1.24163572264639 0.227981746747222 no 2665 0.1071854976893 4250 4930451
SGTC_2889 9059656 51.95 µM -1.24177515634776 0.227958112957041 no 2666 0.107159765711333 4383 3949838
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.24279621351699 0.227785087400057 no 2667 0.106971469100099 4309 803109
SGTC_701 4424-0219 185 µM -1.24338807364871 0.22768482624812 no 2668 0.106862431499865 4349 2911779
SGTC_832 4083-0019 164 µM -1.24444964457437 0.227505058305683 no 2669 0.106667060654454 4408 1990758
SGTC_2001 4023502 57.655 µM -1.2478237976527 0.226934205520336 no 2670 0.106047795836309 4339 108941 YCR052W RSC6
SGTC_1741 st038134 10.228 µM -1.24880394930677 0.22676853106883 no 2671 0.105868394565273 4382 1272587
SGTC_2584 androsterone 48.74 µM -1.24919653710071 0.226702191333672 no 2672 0.105796599132929 4254 2754130 A steroid.
SGTC_3207 9114163 49.47 µM -1.24967873778903 0.226620723743832 no 2673 0.105708463698367 4339 849233
SGTC_2892 9047358 58.44 µM -1.25060229489308 0.226464735328856 no 2674 0.105539806462772 4318 6466771
SGTC_32 0928-0142 34.1 µM -1.25104719839379 0.226389612953671 no 2675 0.10545862900424 4310 2244242
SGTC_2735 sertaconazole 140 nM -1.25113503894696 0.226374782657333 no 2676 0.105442606884542 4469 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1017 4239-0030 168 µM -1.25325756173479 0.226016599740223 no 2677 0.105055993788712 4342 1149593
SGTC_433 pimozide 108 µM -1.25335965644562 0.225999378991065 no 2678 0.105037423347171 4247 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1933 st074711 15.9 µM -1.25532002357652 0.225668859422442 no 2679 0.104681304545459 4303 17250958
SGTC_3183 9108214 49.47 µM -1.25638247239215 0.225489843983592 no 2680 0.104488666687719 4296 4974831
SGTC_414 piperonyl butoxide 100 µM -1.2563852443636 0.225489377030309 no 2681 0.104488164423995 4333 5794 A potent inhibitor of cytochrome P450.
SGTC_38 0929-0051 58.268 µM -1.25825356537375 0.225174772988331 no 2682 0.104150034247348 4309 1379719
SGTC_1607 st000305 50.6 µM -1.26121575582069 0.224676483758855 no 2683 0.103615561755825 4333 5457690
SGTC_1423 4048-0112 5.59 µM -1.26144917726646 0.224637245027392 no 2684 0.103573529922295 4397 X1423
SGTC_3122 9126309 49.47 µM -1.26349784986537 0.224293024836608 no 2685 0.103205159419008 4412 17591206
SGTC_3110 9122132 49.47 µM -1.26651793592113 0.223786133222684 no 2686 0.102663856083607 4401 918317
SGTC_2315 7733312 200 µM -1.27049442870051 0.223119712402833 no 2687 0.101954283070314 4250 726316
SGTC_2226 7298446 200 µM -1.27110050103224 0.223018240008306 no 2688 0.101846448562582 4355 3283010
SGTC_1310 1188-0297 994 nM -1.27275910229762 0.222740681101928 no 2689 0.101551768939609 4222 1588352
SGTC_3302 9125395 16.351 µM -1.27476064451577 0.222405994967265 no 2690 0.101196987216951 4286 17599668
SGTC_3260 9137109 49.47 µM -1.2779973243556 0.22186538380353 no 2691 0.100625184845028 4286 17478346
SGTC_837 0091-0265 12.5 µM -1.27881334337197 0.221729205595111 no 2692 0.100481396981329 4337 759367
SGTC_2974 9094440 9.66 µM -1.29150653104662 0.219617109138601 no 2693 0.0982640459480403 4345 25236134
SGTC_1497 4476-2978 41.3 µM -1.29175400046777 0.219576046354634 no 2694 0.0982211750117651 4406 1528379
SGTC_98 0074-0023 107.663 µM -1.29302093050311 0.219365892804356 no 2695 0.09800191006762 4378 3563821
SGTC_1656 st012921 11 µM -1.29651310138783 0.218787223472996 no 2696 0.0973993846511185 4260 6732821
SGTC_3348 9149464 3.537 µM -1.29898557959402 0.218378053728052 no 2697 0.0969744390282019 4308 1951442
SGTC_2997 9067075 71.4286 µM -1.30093928292589 0.218055047878862 no 2698 0.0966396192504552 4332 27209819
SGTC_2186 6124449 200 µM -1.30184581000304 0.217905265314608 no 2699 0.0964845501060652 4369 3834182 YLR033W RSC58
SGTC_1074 carmofur 3.8 µM -1.30395155243301 0.217557569308703 no 2700 0.0961250507121784 4410 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3006 9075424 71.4286 µM -1.30431137812014 0.217498187655127 no 2701 0.0960637187113563 4332 7465181
SGTC_778 3456-2434 196 µM -1.30648733989902 0.21713929039267 no 2702 0.0956934407741017 4315 5539063
SGTC_2361 9034121 116 µM -1.30703103364562 0.217049668468312 no 2703 0.0956010859620538 4395 6496917
SGTC_514 4466-0038 2.65 nM -1.30836684372869 0.216829565688957 no 2704 0.0953744564784606 4166 5722064
SGTC_1203 3992-3522 103 µM -1.30975539815732 0.21660090901907 no 2705 0.095139298033574 4471 5322312
SGTC_150 3970-0969 77.2 µM -1.31278101416412 0.216103156794937 no 2706 0.0946283746854375 4431 6615640
SGTC_2560 caryophyllene 100 µM -1.31610335129827 0.21555735406424 no 2707 0.0940696781552419 4412 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1804 st050076 49.1 µM -1.32294419323881 0.214436042836146 no 2708 0.0929269686128007 4411 3895976
SGTC_1440 4100-1550 40 µM -1.32380553812599 0.214295096983724 no 2709 0.0927838181932314 4381 742806
SGTC_678 1218-2179 85.9 µM -1.33239897581487 0.212891866500149 no 2710 0.0913645592460646 4430 6820081 YOR116C RPO31
SGTC_751 0833-0568 350 µM -1.33250021304152 0.212875367402694 no 2711 0.0913479357512031 4411 6954252
SGTC_1236 0330-0013 258 µM -1.33266932683273 0.212847807813298 no 2712 0.0913201716963731 4395 4617066
SGTC_97 0535-0701 19.132 µM -1.33465690423522 0.212524058830184 no 2713 0.0909943322603447 4296 2832013 YGL099W LSG1
SGTC_3349 9149703 23.001 µM -1.33641891835424 0.212237291678009 no 2714 0.0907061930791471 4403 4910494
SGTC_3082 9117008 49.47 µM -1.33936448512371 0.211758407192475 no 2715 0.0902260226130357 4422 41448529
SGTC_527 4476-4215 268 µM -1.34029366953973 0.211607473500819 no 2716 0.0900749443884154 4400 4418754
SGTC_1150 3909-7983 10.9 µM -1.34094226188229 0.211502155604083 no 2717 0.0899695997123295 4392 23965914
SGTC_2749 bexarotene 57.39 µM -1.34134412697271 0.211436916480354 no 2718 0.08990437454643 4413 82146 An retinoic acid receptor inhibitor.
SGTC_2606 farnesol 9.78 µM -1.34188324112655 0.211349414737875 no 2719 0.0898169282216067 4401 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3283 9109332 35.8195 µM -1.34582984155171 0.210709502040185 no 2720 0.089178699559647 4235 17027281
SGTC_2919 7978188 46.38 µM -1.34909215657966 0.210181400366587 no 2721 0.0886536836269623 4414 2980291
SGTC_1400 3771-8998 51.5 µM -1.35026183287394 0.209992243343762 no 2722 0.0884660052313138 4337 670767
SGTC_2109 5483026 200 µM -1.35107781561276 0.209860343981155 no 2723 0.0883352535183472 4400 759335
SGTC_360 0957-0399 1.01 µM -1.35153067643085 0.209787162404943 no 2724 0.0882627500264613 4414 6752301 YPR165W RHO1
SGTC_604 1000-0114 314 µM -1.35425092670564 0.209347890185738 no 2725 0.0878281682521869 4412 1572745
SGTC_2866 9034245 58.44 µM -1.35658322430706 0.208971696812382 no 2726 0.0874568375344607 4421 6462273
SGTC_2785 7756463 72.73 µM -1.35660195149984 0.20896867777854 no 2727 0.0874538606824523 4377 2201551
SGTC_1980 st071811 45.7 µM -1.35902153893429 0.208578829237108 no 2728 0.0870698817729724 4478 4974850
SGTC_1968 st069590 43.6 µM -1.35908488207482 0.208568629032391 no 2729 0.0870598464087746 4371 6384066
SGTC_2359 9039622 200 µM -1.36059953693171 0.208324810360421 no 2730 0.0868201390105815 4365 6463596
SGTC_2289 7946404 165.07 µM -1.36740548737321 0.207231312506661 no 2731 0.085749121655944 4382 1246120 YPR165W RHO1
SGTC_708 3448-5400 146 µM -1.36929976864333 0.206927567231916 no 2732 0.0854527951495519 4361 3462195
SGTC_1416 3966-0321 25.3 µM -1.37230550297814 0.206446143157338 no 2733 0.0849841766270341 4454 582530 YLR208W SEC13
SGTC_1637 st007924 17.4 µM -1.37526052121193 0.205973489718577 no 2734 0.084525345600775 4328 683336
SGTC_875 0709-0210 25.7 µM -1.37761688842225 0.205597050532034 no 2735 0.0841608019446771 4396 6251364
SGTC_510 ag-490 170 µM -1.37832224299943 0.205484446761128 no 2736 0.0840519093478612 4546 5328779
SGTC_2426 5582046 32.21 µM -1.37855787172331 0.205446838830331 no 2737 0.0840155565803799 4414 2251934
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.38350340233701 0.20465844243964 no 2738 0.0832552824071091 4355 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1459 k035-0031 35.7 µM -1.38559771958904 0.204325118121501 no 2739 0.0829348874769266 4156 3877128 YMR208W ERG12
SGTC_2012 4023501 200 µM -1.38582795852121 0.204288493816103 no 2740 0.0828997215004458 4420 3477460
SGTC_342 k048-0088 23.3 µM -1.38623421368305 0.204223879991487 no 2741 0.082837698714862 4414 6820570
SGTC_984 1492-0255 2.91 µM -1.38911670931235 0.203765776195913 no 2742 0.0823986317548767 4391 1585198
SGTC_457 grayanotoxin iii 135 µM -1.38947948016515 0.203708165868624 no 2743 0.0823434982144965 4266 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_55 0767-0285 6.563 µM -1.38951866064807 0.203701944338921 no 2744 0.0823375452676114 4345 3116166
SGTC_2624 nerol 100 µM -1.39056437426569 0.203535935715911 no 2745 0.0821787828877438 4343 637566 A natural product oil.
SGTC_2929 9013348 24.6 µM -1.39146054171353 0.203393732002958 no 2746 0.0820429084852175 4396 2995952
SGTC_371 0195-0006 7.36 µM -1.39671454071971 0.20256122144936 no 2747 0.0812497149100081 4279 3928593
SGTC_1851 st056236 18.9 µM -1.39715723446645 0.202491168578031 no 2748 0.0811831468587308 4412 5393171
SGTC_1148 3909-7663 27.7 µM -1.39734245687384 0.202461862858927 no 2749 0.0811553070989275 4474 4084526
SGTC_2576 guaiol 23.12 µM -1.40092288587802 0.201895869112776 no 2750 0.0806185671192869 4333 227829
SGTC_1317 1273-0028 910 nM -1.40209871636179 0.20171020080584 no 2751 0.0804428851740055 4448 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_137 0438-0332 85.389 µM -1.40268869188381 0.201617079866658 no 2752 0.0803548454186323 4380 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_363 0455-0021 3.06 µM -1.40287997677176 0.201586893247802 no 2753 0.0803263163533895 4387 4597466
SGTC_2904 7225135 42.03 µM -1.40608721073702 0.201081163883474 no 2754 0.0798491147965506 4492 4446116
SGTC_671 0560-0003 407 µM -1.40780502663175 0.200810605086282 no 2755 0.0795944057675172 4372 3238678
SGTC_246 cycloheximide 667 µM -1.40924645781854 0.200583745995625 no 2756 0.0793811524064441 4344 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1987 st072290 61.9 µM -1.41201233216335 0.200148871106282 no 2757 0.0789731650356375 4479 54697379
SGTC_1161 k007-0610 110 µM -1.41316906647078 0.199967167430976 no 2758 0.0788030097709345 4383 5843850
SGTC_1406 3909-7906 11.9 µM -1.41595139927854 0.199530515740197 no 2759 0.0783948672384438 4472 X1406
SGTC_1568 digitonin 820 nM -1.41630897116853 0.199474441031782 no 2760 0.0783425311817431 4419 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2630 antimycin a 100 µM -1.41790340506444 0.199224516117075 no 2761 0.0781094840704731 4391 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1715 st032160 10.2275 µM -1.41860858101352 0.19911404111418 no 2762 0.0780065813786927 4357 5289825
SGTC_289 k017-0060 526 µM -1.42034567567707 0.198842060071576 no 2763 0.0777535348958482 4440 5512909
SGTC_304 1310-0298 97 µM -1.42045915365222 0.19882430035136 no 2764 0.077737026010794 4203 1550234
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.42115739200646 0.198715044527225 no 2765 0.0776355041716206 4411 2724 A muscle relaxant with antifungal properties.
SGTC_1667 st014849 34.6 µM -1.42519581967048 0.198083847953811 no 2766 0.0770503021983864 4533 5348460
SGTC_2006 4011487 200 µM -1.42727678834202 0.197759070713526 no 2767 0.0767500642181267 4419 45595294
SGTC_2511 berberine 10.47 µM -1.43095833824685 0.197185279188526 no 2768 0.0762210778497327 4439 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_228 caffeine 993.056 µM -1.43140638731162 0.197115516887221 no 2769 0.0761568894346624 4440 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_175 3793-3120 23.7 µM -1.43307671211723 0.196855575010012 no 2770 0.0759179579008403 4446 5322297
SGTC_2046 4110841 106 µM -1.43689514061063 0.196262117695514 no 2771 0.0753738954532513 4462 44119630 YMR134W ERG29
SGTC_2917 7979103 53.79 µM -1.43779909577183 0.196121784605858 no 2772 0.0752455330045717 4454 2980565
SGTC_1920 st075728 45.7 µM -1.44214143942059 0.195448513037736 no 2773 0.0746312384049561 4439 3400306
SGTC_297 0986-0032 24 µM -1.44488984063446 0.19502310537023 no 2774 0.0742444152010455 4433 2847425
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.44659241583699 0.194759857099569 no 2775 0.0740055557991115 4414 6708514
SGTC_165 k038-0023 64.381 µM -1.45144605810453 0.194010585339815 no 2776 0.0733278462132651 4447 46368543
SGTC_3105 9121040 49.47 µM -1.45656545025623 0.193222195093241 no 2777 0.0726181852727132 4428 41448907
SGTC_2013 4024628 200 µM -1.45858585211656 0.192911590598303 no 2778 0.0723395649568466 4490 5230760
SGTC_694 1315-0438 43.2 µM -1.45930985585776 0.192800360856838 no 2779 0.07223992197353 4492 6793154
SGTC_582 0987-0078 156 µM -1.46153359128231 0.192458970225546 no 2780 0.0719345319945799 4522 1625765
SGTC_2741 miltefosine 3.04 µM -1.46392530532117 0.192092204109155 no 2781 0.0716071791652783 4524 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_52 0329-0193 875 nM -1.46474565215911 0.191966503594934 no 2782 0.0714951622907185 4503 3739292
SGTC_3197 9113331 49.47 µM -1.46581903185787 0.191802107287111 no 2783 0.071348797379182 4457 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1402 3909-7673 35.9 µM -1.46782761908479 0.191494708452546 no 2784 0.0710755265892618 4501 5328014
SGTC_2350 9023895 38.85 µM -1.46804776380806 0.19146103535891 no 2785 0.0710456245673885 4452 2997209
SGTC_2571 chrysanthemic acid 100 µM -1.46836954069064 0.191411823249999 no 2786 0.0710019353407099 4449 2743 An insecticide.
SGTC_1340 1486-1359 257 µM -1.46877014709465 0.191350565897075 no 2787 0.0709475718832378 4424 4309068
SGTC_2471 5466956 24.79 µM -1.47418766485053 0.190523345079427 no 2788 0.0702155350602536 4470 724419
SGTC_3329 9141233 27.5565 µM -1.47606192243556 0.190237669727349 no 2789 0.0699636348631424 4445 4909101 YNL103W MET4
SGTC_2737 bleomycin 30.5 nM -1.47819424745258 0.189912979790878 no 2790 0.069677896601785 4569 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_945 3381-0768 11.3 µM -1.48008990182005 0.189624614040574 no 2791 0.069424628054695 4488 1126236 YIL048W NEO1
SGTC_666 0272-0154 136 µM -1.48181071327619 0.189363078655747 no 2792 0.0691953338438002 4472 6870312
SGTC_2808 7946468 45.46 µM -1.48346604548756 0.189111704679112 no 2793 0.0689753156325791 4471 2970879
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.48628093114179 0.188684716386201 no 2794 0.068602414193622 4517 94937 An inhibitor of serotonin biosynthesis.
SGTC_2526 patulin 37.61 µM -1.4868715853392 0.188595195900583 no 2795 0.0685243651237049 4495 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_969 1313-0238 134 µM -1.48927389301021 0.188231368255816 no 2796 0.0682076297619627 4520 5212874
SGTC_2664 lyso-paf C-16 73.48 µM -1.49092580804379 0.187981438463155 no 2797 0.0679904873654227 4453 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3134 9127454 49.47 µM -1.49098922068915 0.187971848404971 no 2798 0.0679821624938647 4538 24262820
SGTC_1502 4534-4282 27.7 µM -1.49105029455522 0.187962612331968 no 2799 0.0679741454034971 4473 3278949
SGTC_1666 st014829 29 µM -1.49159146841219 0.187880783982943 no 2800 0.0679031380753249 4489 3858230
SGTC_1950 st077106 7.18 µM -1.49515532935152 0.187342458945967 no 2801 0.0674369543423195 4399 13831864
SGTC_3173 9105693 49.47 µM -1.4961078685311 0.187198738523988 no 2802 0.067312773884428 4470 17096658
SGTC_815 1582-0027 36.9 µM -1.49640639218418 0.187153710900584 no 2803 0.0672738924084676 4505 3128206
SGTC_805 3852-0218 479 µM -1.50285675837641 0.186182410698605 no 2804 0.0664379929145312 4466 6615355
SGTC_2983 9022671 12.99 µM -1.50967404668479 0.185159261618726 no 2805 0.0655633084096796 4476 6405161
SGTC_1740 st038286 13.222 µM -1.5115833337088 0.184873340063708 no 2806 0.0653199470763852 4503 716786
SGTC_3189 9110682 49.47 µM -1.51294610516339 0.184669428798836 no 2807 0.0651466746603868 4506 17122418
SGTC_914 3820-6779 408 µM -1.51405665783834 0.18450336044186 no 2808 0.0650057350655775 4433 2893481
SGTC_2063 5246145 200 µM -1.51715040871192 0.184041221224792 no 2809 0.0646143568257361 4543 711240
SGTC_2837 9008476 45.46 µM -1.5192863892616 0.183722573032342 no 2810 0.0643452120982145 4466 2992805
SGTC_2344 7990960 76.95 µM -1.52293634889546 0.183178863649661 no 2811 0.0638873153652597 4489 140813
SGTC_1700 st030840 7.9285 µM -1.52304610887584 0.183162529019365 no 2812 0.0638735850482128 4555 5499307
SGTC_139 0099-0334 718.624 µM -1.52378989995913 0.183051860954602 no 2813 0.0637806016947125 4513 97690
SGTC_982 1491-0518 27.5 µM -1.52439732938523 0.182961512982042 no 2814 0.0637047434185989 4462 3091256
SGTC_1787 fluconazole 80 µM -1.52465920665834 0.182922570407963 no 2815 0.0636720607730009 4174 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_572 0960-0087 17.7 µM -1.52496569436745 0.182877000589604 no 2816 0.0636338272528707 4458 6796365
SGTC_939 1165-0479 45.3 µM -1.52727920602417 0.1825332470619 no 2817 0.0633457989516039 4481 1377347
SGTC_189 3970-0742 2.116 µM -1.52954709275345 0.182196664711145 no 2818 0.0630644369517073 4481 2891807
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.5324888923285 0.181760643747355 no 2819 0.0627009182741785 4511 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.53379347509096 0.18156749317115 no 2820 0.0625402343607909 4575 279621
SGTC_2110 5483698 200 µM -1.53397298648025 0.181540925590975 no 2821 0.0625181493034421 4495 2848765 YHR062C RPP1
SGTC_2635 hydroquinidine 100 µM -1.53666258088256 0.181143158568757 no 2822 0.0621879794568016 4448 442912 An experimental heart treatment.
SGTC_2367 9070478 135.38 µM -1.53908784310784 0.180784952389782 no 2823 0.061891426250816 4446 572802
SGTC_1398 3558-0053 112 µM -1.54223251229743 0.180321152969028 no 2824 0.0615085510388888 4492 4532369
SGTC_724 3910-0327 137 µM -1.54260071397148 0.180266896692881 no 2825 0.061463842353546 4536 2885483
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.54389384147847 0.180076429359503 no 2826 0.0613070261455082 4463 676296 Flavone; oxidizing agent.
SGTC_1807 st050092 58.9 µM -1.54439820817024 0.18000217444456 no 2827 0.0612459469337593 4518 5008496
SGTC_1605 st000082 49.1 µM -1.55005207536263 0.179171105304501 no 2828 0.0605645087420455 4471 1114022
SGTC_1471 k673-0312 37 µM -1.55340670378827 0.178679146924836 no 2829 0.0601630011796529 4507 24099884
SGTC_1019 4262-0212 3.4 µM -1.55440325520566 0.178533166046704 no 2830 0.0600441286286761 4523 4677213
SGTC_1186 1319-0216 26 µM -1.55501278877827 0.178443914918236 no 2831 0.0599715117777353 4553 4565136
SGTC_1493 4348-0038 111 µM -1.55889453815681 0.177876188311342 no 2832 0.0595106716411451 4515 800424
SGTC_209 4077-0173 175.592 µM -1.56046507991712 0.177646812243422 no 2833 0.059325007941687 4500 15993494
SGTC_403 arphamenine a 50 µM -1.56102610146994 0.177564920866048 no 2834 0.0592587962267852 4526 5487158 An arginine aminopeptidase inhibitor.
SGTC_1422 4031-0024 15.5 µM -1.56225429528808 0.177385726655861 no 2835 0.0591140471944665 4471 782427
SGTC_2292 7671323 168.05 µM -1.56374259416092 0.177168736023684 no 2836 0.0589390152352244 4541 937504
SGTC_2269 7935389 174.42 µM -1.56419264703074 0.177103152355694 no 2837 0.0588861667429135 4530 97605
SGTC_2682 pyrogallin 40.03 µM -1.56558218836175 0.176900759121636 no 2838 0.0587232312681133 4537 822798 An ATP competetive kinase inhibitor.
SGTC_372 0155-0182 15.9 µM -1.57393952062328 0.175686559685454 no 2839 0.0577507160680235 4414 771486
SGTC_2061 5245884 80.95 µM -1.59075469897706 0.173259601250007 no 2840 0.0558323957911488 4517 573863
SGTC_500 h-89 112 µM -1.59146707875849 0.173157256044573 no 2841 0.0557522493289011 4511 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.5921429150264 0.173060196521823 no 2842 0.0556762981492106 4516 16623 A steroid.
SGTC_842 0271-0008 11.1 µM -1.59776995183903 0.17225342142322 no 2843 0.0550470921203403 4557 1221709
SGTC_1446 4239-0190 62 µM -1.59789378854468 0.172235693394596 no 2844 0.0550333083486883 4550 1340085
SGTC_2481 5478948 45.16 µM -1.6017524487687 0.17168388450092 no 2845 0.0546051809812708 4537 77792
SGTC_263 alizarin 107.927 µM -1.60334236139842 0.171456847454406 no 2846 0.0544295444172222 4582 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2475 5812728 15.03 µM -1.60949040374798 0.170580723215499 no 2847 0.0537545758302511 4510 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2586 curcumin 80 µM -1.61230609788697 0.170180432551585 no 2848 0.053447673515977 4443 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1780 st038448 24.544 µM -1.61654681221045 0.169578692051699 no 2849 0.0529880704174913 4574 728868 YDL195W SEC31
SGTC_757 1066-0008 322 µM -1.61775334627001 0.169407739400259 no 2850 0.0528578821661674 4565 6842497
SGTC_1096 rimcazole 32.2 µM -1.62025653538251 0.169053417842576 no 2851 0.0525885907206319 4507 18528119 A dopamine reuptake inhibitor.
SGTC_3222 9128301 49.47 µM -1.62232012200315 0.168761679336559 no 2852 0.0523674112051091 4506 4911358
SGTC_2653 dihydrofissinolide 100 µM -1.62344392034367 0.168602939070797 no 2853 0.0522472711572902 4624 6857746
SGTC_2617 dihydrotanshinone i 20.83 µM -1.62408584223904 0.168512308546285 no 2854 0.0521787445609245 4500 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1752 st044819 83.042 µM -1.62440202355695 0.168467679617509 no 2855 0.052145017748675 4503 441209 YML126C ERG13
SGTC_691 1548-0686 185 µM -1.62512050093342 0.168366294941057 no 2856 0.0520684427113402 4530 46495133
SGTC_1519 esterone 74 µM -1.62756564114905 0.168021554145791 no 2857 0.0518085097563368 4554 698 A steroid.
SGTC_448 monastrol 171 µM -1.62760800984514 0.168015584581929 no 2858 0.0518040148185853 4487 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_920 mycophenolic acid 780.421 nM -1.62964157624378 0.16772922448285 no 2859 0.0515886359255133 4543 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_153 4077-0274 519.67 µM -1.63016728138922 0.167655247577801 no 2860 0.0515330734674834 4564 3121976
SGTC_1149 3909-7961 23.3 µM -1.63123579685853 0.167504951509824 no 2861 0.0514202873405727 4607 735261
SGTC_346 4513-0042 7.16 µM -1.63205256318404 0.167390124718843 no 2862 0.0513342068163307 4506 2827372
SGTC_2734 clemastine 41.6 µM -1.633885498982 0.167132622320064 no 2863 0.0511414475677761 4630 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2516 gossypol 71.55 µM -1.63457026293939 0.167036487917241 no 2864 0.0510695828589648 4571 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_767 0929-0023 86 µM -1.63619381629019 0.166808698864026 no 2865 0.0508995151075214 4588 1204563
SGTC_891 0929-0073 133 µM -1.64031010661876 0.166232070505086 no 2866 0.0504703526474543 4579 5603632
SGTC_420 mitomycin C 81.9 mM -1.64080804622557 0.166162404292346 no 2867 0.0504186337497527 4538 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_395 anisomycin 6.25 µM -1.64473117896971 0.165614182667254 no 2868 0.0500126300228377 4574 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2101 5377231 179.231 µM -1.64698014062258 0.165300439091725 no 2869 0.0497810639368196 4588 2844213
SGTC_2329 6138490 200 µM -1.6500929181879 0.164866823048132 no 2870 0.0494619664905692 4572 720019
SGTC_1765 st044815 90.4 µM -1.65048305929454 0.164812527623714 no 2871 0.0494220876951127 4575 645695
SGTC_857 0438-0306 1.35 µM -1.6507989178956 0.164768578483086 no 2872 0.0493898205902568 4606 4686136
SGTC_3259 9138485 49.47 µM -1.65120050565822 0.164712711794184 no 2873 0.0493488199554114 4538 17646153
SGTC_1273 0849-0096 14.1 µM -1.65244480517857 0.164539689593398 no 2874 0.0492219540644131 4581 5286025
SGTC_2714 st079313 56.9 µM -1.65283821849495 0.164485009245357 no 2875 0.0491818967916351 4561 2939799
SGTC_835 0312-0010 67.2 µM -1.65292747577482 0.164472605053741 no 2876 0.0491728122558959 4598 1626196
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.65303264625349 0.164457990163857 no 2877 0.0491621098071885 4581 6710655
SGTC_1636 st007707 68.9 µM -1.65462642449649 0.164236615716348 no 2878 0.0490001499816048 4584 403051
SGTC_726 3448-4391 34.2 µM -1.65865918984089 0.16367733154134 no 2879 0.0485922436523339 4632 1356692
SGTC_3121 9125696 49.47 µM -1.6591043940667 0.163615664253752 no 2880 0.0485473790017423 4664 1235365
SGTC_1974 st069448 26.9 µM -1.65932443966523 0.163585190295886 no 2881 0.0485252165383264 4557 6323587 YNR016C ACC1
SGTC_69 0096-0274 206.684 µM -1.66267644833641 0.163121428728781 no 2882 0.0481886095304141 4616 6741392
SGTC_39 0986-0283 58.349 µM -1.6632611619537 0.163040619264493 no 2883 0.0481300847036838 4581 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_148 3253-0744 288.01 µM -1.66557272531056 0.162721407966151 no 2884 0.0478992736717258 4463 6893655
SGTC_1449 4112-4002 201 µM -1.66665614415286 0.162571935144242 no 2885 0.0477913990315602 4602 2059539
SGTC_3278 9139605 49.47 µM -1.66824685301631 0.162352636472024 no 2886 0.0476333667341107 4553 7958859
SGTC_674 0498-0004 451 µM -1.66919964084674 0.162221375266953 no 2887 0.0475389106373119 4570 4231473
SGTC_1481 3346-2004 36 µM -1.67484529374609 0.161445017717625 no 2888 0.0469822947369588 4654 2770522
SGTC_2210 7115885 190.385 µM -1.67540626409873 0.161368008865166 no 2889 0.0469272742085354 4652 2927039
SGTC_1651 st011928 86.1 µM -1.6759943526947 0.161287303002359 no 2890 0.0468696493906468 4583 720198
SGTC_597 k018-0003 82.8 µM -1.6761573658055 0.161264936691312 no 2891 0.0468536863361572 4625 6786234
SGTC_2736 butenafine 14.65 µM -1.67710682443764 0.161134705866069 no 2892 0.0467607972736461 4527 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2861 9024595 19.48 µM -1.68029790491872 0.160697509951162 no 2893 0.0464496842485768 4539 16482810
SGTC_613 3914-0030 117 µM -1.68038125600856 0.160686100775552 no 2894 0.0464415802904574 4324 1145395
SGTC_1867 st057372 64 µM -1.6820329399377 0.160460125831568 no 2895 0.0462812263290061 4563 688837
SGTC_1326 1431-2094 10.8 µM -1.68288908263195 0.160343074513984 no 2896 0.046198282712596 4592 616278
SGTC_1697 st025554 27.742 µM -1.68362194506533 0.160242922337404 no 2897 0.0461273774289345 4608 1269519
SGTC_65 0798-0905 34.986 µM -1.69306257951162 0.158956432407804 no 2898 0.0452217780636597 4557 3602145
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.69505987167325 0.15868512811915 no 2899 0.0450320318080981 4553 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_330 1488-0319 80.1 µM -1.6962128193453 0.158528654547247 no 2900 0.0449227917970636 4605 6846614
SGTC_2555 cholic acid 100 µM -1.70161466582745 0.157796885129132 no 2901 0.0444138132221841 4556 6708657 Influences liver metabolism.
SGTC_106 0092-0003 11.579 µM -1.70608690544042 0.157192727688957 no 2902 0.0439959501095926 4523 1072148
SGTC_379 3970-0972 5.9 µM -1.70635651571451 0.157156354556927 no 2903 0.0439708607785742 4601 2898042 YBL034C STU1
SGTC_752 1896-0090 130 µM -1.70697482413274 0.157072959448224 no 2904 0.0439133659483626 4608 772567
SGTC_1199 1638-0010 4.46 µM -1.70761679707883 0.156986403361356 no 2905 0.0438537347935063 4572 3111136
SGTC_1092 toremifene 6.32 µM -1.70795804274473 0.156940406580865 no 2906 0.0438220639914374 4593 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3017 9080681 49.47 µM -1.70947483415084 0.156736064335404 no 2907 0.0436815147102597 4611 16451914
SGTC_839 0122-0028 230 µM -1.71090188347096 0.156543972094699 no 2908 0.0435496134389916 4614 759448
SGTC_553 k007-0256 45.7 µM -1.71401658522787 0.156125246928358 no 2909 0.0432628399647431 4635 6287000
SGTC_2052 5265182 7.135 µM -1.71565089820522 0.155905833425623 no 2910 0.0431129783800166 4569 1239884
SGTC_1876 myriocin 605 nM -1.71863260296448 0.155506050799342 no 2911 0.0428406455996747 4578 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2466 5983409 37.09 µM -1.71870113143848 0.155496870559028 no 2912 0.04283440296133 4602 2879657
SGTC_2007 4011539 71.82 µM -1.72243629467155 0.154997039896585 no 2913 0.042495256837436 4572 45595301
SGTC_3325 9138760 55.175 µM -1.72304065456597 0.15491626572884 no 2914 0.042440586710052 4539 43844959
SGTC_1160 4092-0570 10.5 µM -1.72318901877337 0.154896440743314 no 2915 0.042427174450106 4606 4994975
SGTC_2489 cantharidin 73.42 µM -1.72415000737278 0.154768070399627 no 2916 0.0423403832015811 4555 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1485 3909-9022 254 µM -1.72420450770236 0.154760792268014 no 2917 0.0423354653360148 4656 714516
SGTC_441 propafenone 146 µM -1.72476032139251 0.154686580213096 no 2918 0.0422853375812714 4595 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2040 5100729 123 µM -1.72620601254239 0.154493662164923 no 2919 0.0421551783769447 4630 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.7291199651386 0.154105297761545 no 2920 0.0418938133014822 4611 390807
SGTC_2958 9077254 16.72 µM -1.72965118884953 0.154034567237798 no 2921 0.0418463072317384 4596 16457351
SGTC_2654 protoveratrine a 100 µM -1.73000423091864 0.153987572839981 no 2922 0.0418147596559166 4616 5702278 A heart drug and vasodilator.
SGTC_26 0302-0163 425.158 µM -1.73058707220601 0.15391000999928 no 2923 0.0417627195395861 4663 3100915
SGTC_2986 9022445 71.43 µM -1.7312651571574 0.15381980494822 no 2924 0.0417022414299766 4576 6459286
SGTC_2786 7743617 45.45 µM -1.73176930573448 0.153752761186241 no 2925 0.0416573226240649 4527 583674
SGTC_1022 4477-0945 21.3 µM -1.73250746953927 0.153654632013466 no 2926 0.04159162415831 4555 4648966
SGTC_2900 5328528 85.29 µM -1.73481495810077 0.153348149214034 no 2927 0.0413867929391484 4592 795359
SGTC_1808 st050063 61.5 µM -1.74141272105144 0.152474064069293 no 2928 0.0408056299808578 4559 4011993
SGTC_377 3970-0964 33.1 µM -1.74383157378569 0.152154439404638 no 2929 0.040594231556726 4595 16481235
SGTC_1805 st050013 60.3 µM -1.74395377186461 0.152138304092996 no 2930 0.0405835755476371 4565 4037144
SGTC_1228 0124-0032 52.5 µM -1.74458394080678 0.152055113194631 no 2931 0.0405286591204131 4620 X1228
SGTC_2184 6075246 200 µM -1.74499457066591 0.152000920711062 no 2932 0.0404929070232125 4587 2267320
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.74527590323429 0.151963799520464 no 2933 0.0404684271699655 4636 16486 A toxic proline analog.
SGTC_1229 0139-0193 12.2 µM -1.74655351729652 0.15179529703554 no 2934 0.0403574080851364 4651 3090752
SGTC_3266 9136860 49.47 µM -1.75123456017982 0.15117898285656 no 2935 0.039952757327054 4353 4871271 YPR165W RHO1
SGTC_329 k048-0121 21.3 µM -1.7545556820704 0.150742729145641 no 2936 0.0396676688179883 4620 6832902
SGTC_1195 1502-0147 41.1 µM -1.75633530782352 0.150509307509033 no 2937 0.0395155859329176 4629 817940
SGTC_66 0109-0187 42.4 µM -1.76018142522657 0.150005660819107 no 2938 0.03918852517232 4458 759417
SGTC_335 4077-0256 27.6 µM -1.76180494499001 0.149793399591003 no 2939 0.0390511294888675 4531 3121989
SGTC_2619 obliquin 87.91 µM -1.7623887980201 0.149717114839173 no 2940 0.0390018149918612 4601 6708593 A bioactive alkalod. YER133W GLC7
SGTC_643 k048-0106 28.4 µM -1.76469811712512 0.149415639107927 no 2941 0.0388072576040349 4637 6763920
SGTC_1466 k213-0079 57.5 µM -1.76562839377809 0.149294308437645 no 2942 0.0387291066001725 4624 3657981
SGTC_2782 7736369 71.43 µM -1.76756707244699 0.149041669098054 no 2943 0.038566653402638 4592 2950836 YOL077C BRX1
SGTC_1330 1469-0054 61.8 µM -1.76898358284271 0.148857256899523 no 2944 0.038448307172058 4579 7102664
SGTC_3076 9116187 49.47 µM -1.77175566375415 0.148496807466625 no 2945 0.0382175625890999 4630 27241210
SGTC_156 3474-0145 5.642 µM -1.77569466433842 0.147985629932146 no 2946 0.0378916286608525 4550 2265471
SGTC_954 1189-0853 2.85 µM -1.77724131955314 0.147785237624484 no 2947 0.0377642718895626 4563 2828194
SGTC_868 0527-0199 213 µM -1.78087709556049 0.147314884386153 no 2948 0.0374662655748659 4610 2849450
SGTC_95 0471-0001 561.058 µM -1.78126943553158 0.147264188171497 no 2949 0.0374342225595355 4589 4015405
SGTC_566 0958-0068 16.5 µM -1.78243252211451 0.147113968646352 no 2950 0.0373393629758524 4529 6815365
SGTC_190 3970-0790 3.722 µM -1.78532538408687 0.146740784063692 no 2951 0.0371042768920778 4589 2832352
SGTC_3051 9093778 49.47 µM -1.78719417564376 0.146500044443617 no 2952 0.0369530551788122 4704 17217378
SGTC_1768 st044301 37.178 µM -1.79503281832146 0.145493151931746 no 2953 0.0363242356418624 4643 3931349
SGTC_184 1494-0393 24.714 µM -1.79537370768659 0.145449469728487 no 2954 0.0362970893058979 4611 3090647
SGTC_1208 2323-2347 50.3 µM -1.7954694293912 0.145437205355919 no 2955 0.036289469604103 4631 5412760
SGTC_1201 1889-3372 45.9 µM -1.79566315384633 0.145412386479455 no 2956 0.0362740526297744 4537 5392199
SGTC_1052 3253-3998 198 µM -1.79920787255215 0.144958760219939 no 2957 0.035992902299657 4587 5450317
SGTC_1407 3909-7909 12.3 µM -1.80257087645825 0.14452927001817 no 2958 0.0357278171410724 4650 4411780
SGTC_374 0880-0231 82.3 µM -1.80525097186682 0.144187608750997 no 2959 0.0355177089689701 4493 6833587
SGTC_295 k015-0027 31 µM -1.80592226426768 0.144102117063527 no 2960 0.0354652414232117 4674 3887424
SGTC_1154 4088-0362 150 µM -1.80660738557241 0.144014899461906 no 2961 0.035411758569458 4644 6618304
SGTC_2732 terfenadine 20 µM -1.80666203712795 0.144007943720029 no 2962 0.0354074951366683 4696 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_551 k048-0028 34.9 µM -1.82097565600401 0.142193985144466 no 2963 0.0343052787343241 4595 6836383
SGTC_2204 7233102 200 µM -1.82684050569317 0.141455220398627 no 2964 0.0338618768309226 4643 2172480
SGTC_1606 st000094 49.2 µM -1.82717151190722 0.141413602944302 no 2965 0.033836992877667 4651 1242210
SGTC_2955 9076254 12.21 µM -1.82917042085708 0.141162456236501 no 2966 0.0336870410488655 4587 16459619
SGTC_245 methotrexate 289.6 µM -1.83124988410228 0.14090150967016 no 2967 0.033531627072293 4593 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_315 k915-0449 187 µM -1.83156632722825 0.140861828730636 no 2968 0.0335080287131793 4657 20970215 YNL149C PGA2
SGTC_45 0kpi-0036 14.9 µM -1.83190209749929 0.140819732520765 no 2969 0.0334830040072396 4596 2795021
SGTC_3140 9094243 49.47 µM -1.83608050930336 0.140296590433655 no 2970 0.0331728752249873 4610 19291112
SGTC_349 k015-0014 24 µM -1.83691833730331 0.140191852445029 no 2971 0.0331109758984951 4629 2196908
SGTC_1316 1272-0050 65.9 µM -1.8386663612216 0.139973500703217 no 2972 0.032982137016193 4651 7340392
SGTC_2272 7805186 180 µM -1.84086757831992 0.139698867935253 no 2973 0.0328204833134881 4639 2956062 YPR165W RHO1
SGTC_3275 9138069 49.47 µM -1.84906002552463 0.138679965531555 no 2974 0.0322245728598122 4659 17617007
SGTC_2887 9044784 58.44 µM -1.8506918835599 0.138477615941072 no 2975 0.0321069461945151 4562 6465546
SGTC_3239 9133757 49.47 µM -1.85256440145697 0.138245672654707 no 2976 0.0319724094028347 4705 17036923
SGTC_791 1348-1292 225 µM -1.85727598907551 0.137663234291954 no 2977 0.0316359493382719 4631 5437054
SGTC_1475 4092-1048 11.7 µM -1.86016333485624 0.137307134342413 no 2978 0.031431210363756 4650 2881759
SGTC_1366 1683-0113 21.9 µM -1.86749853682897 0.136405305761902 no 2979 0.0309160004795122 4665 708623
SGTC_271 rotenone 740 µM -1.86920399192344 0.136196209962652 no 2980 0.0307972195560899 4672 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_874 0599-0792 117 µM -1.86957355793217 0.136150928583486 no 2981 0.0307715300225708 4631 765305
SGTC_217 ketoconazole 989 nM -1.87315757952571 0.135712327869198 no 2982 0.030523314091022 4465 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2810 7959871 45.46 µM -1.8740833233986 0.135599195843004 no 2983 0.0304594707453056 4584 2974535
SGTC_625 k213-0058 121 µM -1.87832679996619 0.135081441929508 no 2984 0.0301682362412963 4698 3655420
SGTC_2313 7726885 200 µM -1.87890465622429 0.135011041704072 no 2985 0.0301287564817355 4631 726423
SGTC_1308 1187-1617 41.4 µM -1.90015956208794 0.132439031371895 no 2986 0.0287060916065317 4681 2882570
SGTC_690 glyoxal 20.3 µM -1.90472617986339 0.131890870615183 no 2987 0.0284078370253533 4477 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_204 PMA1.184 62.41 µM -1.90624993704828 0.131708312876376 no 2988 0.0283088930537123 4650 2252213 YGL008C PMA1
SGTC_2242 6630449 61.2675 µM -1.9076763133503 0.131537580183738 no 2989 0.0282165325015871 4653 691249 YDR170C SEC7
SGTC_2445 5742597 35.57 µM -1.91266116589066 0.130942109375165 no 2990 0.0278957218740795 4665 1774255
SGTC_578 3460-0051 92 µM -1.91415438258402 0.130764098730404 no 2991 0.0278002162644505 4701 2876744
SGTC_1480 1070-0044 41.2 µM -1.9146949473226 0.130699697715816 no 2992 0.0277657091677065 4706 3124987
SGTC_402 epigallocatechin gallate 10 µM -1.9266877959952 0.129276548635754 no 2993 0.0270092748418574 4638 65064 An antioxidant.
SGTC_3311 9131146 2.8755 µM -1.9274128667908 0.129190852685819 no 2994 0.0269640986899215 4629 4900406 YPR165W RHO1
SGTC_788 1182-0090 188 µM -1.92906555153376 0.128995669457949 no 2995 0.0268613624512934 4655 5715185
SGTC_1000 4048-0884 8.67 µM -1.93013083337589 0.128869967365325 no 2996 0.0267953144554799 4660 13040088
SGTC_1690 st023502 41.2 µM -1.9311488242448 0.128749924969941 no 2997 0.0267323252898357 4682 24207482
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.93444137106545 0.128362196226157 no 2998 0.0265294419949529 4658 688798
SGTC_2733 amorolfine 100 µM -1.94320963500816 0.127333606229973 no 2999 0.0259954172102218 4769 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1550 gossypolone 36.6 µM -1.9469416462837 0.126897554459524 no 3000 0.0257708654942352 4685 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_151 3013-0144 2.285 µM -1.95663539797862 0.125769787465192 no 3001 0.0251951750741608 4447 906558 YHR107C CDC12
SGTC_977 1348-1378 135 µM -1.95715441705018 0.12570960281496 no 3002 0.0251646580929938 4654 X977
SGTC_899 1083-0020 478 µM -1.95761208102106 0.125656549479414 no 3003 0.0251377743399922 4693 767123
SGTC_754 3474-0146 171 µM -1.960691418525 0.12529999258258 no 3004 0.0249575153670303 4672 24762078
SGTC_2928 9011484 9.79 µM -1.96579639995625 0.124710443422107 no 3005 0.0246610669187347 4640 2994751
SGTC_3083 9117465 49.47 µM -1.96894421857553 0.1243478850798 no 3006 0.0244797485054419 4632 16420915
SGTC_1397 3532-0190 20.1 µM -1.96931804735904 0.124304877378647 no 3007 0.0244582900090607 4678 5322280
SGTC_354 2783-3500 4.88 µM -1.97339870876819 0.123836088018391 no 3008 0.0242250773105473 4671 6740761
SGTC_3042 9091578 49.47 µM -1.97456567920525 0.123702253456774 no 3009 0.024158728550031 4672 25236497
SGTC_2438 5259590 200 µM -1.97662793654942 0.123465990174958 no 3010 0.0240418509694102 4699 1201127
SGTC_1357 1503-1303 39.5 µM -1.98610110939007 0.122384754080485 no 3011 0.0235110490641915 4653 292895
SGTC_2434 5670830 169.91 µM -1.98628540035457 0.122363785835161 no 3012 0.0235008214075586 4675 1549830
SGTC_3263 9137018 49.47 µM -1.9864170400484 0.122348809686544 no 3013 0.0234935180478076 4641 43844957
SGTC_1944 st076371 56.9 µM -1.98764792202122 0.122208839165686 no 3014 0.0234253211651446 4668 24208455
SGTC_979 1426-2828 121 µM -1.99197633236882 0.121717524145467 no 3015 0.023186827379376 4709 747872
SGTC_195 4234-0266 16.654 µM -1.99456441365907 0.121424416651589 no 3016 0.023045204043059 4705 2303354
SGTC_3326 9140064 16.379 µM -1.99926152519039 0.120893723863466 no 3017 0.0227900323714749 4643 1868434
SGTC_2099 5377090 177.372 µM -2.00085346255997 0.120714233217262 no 3018 0.0227040919898346 4683 2243829
SGTC_2729 fluphenazine 10.66 µM -2.00129992594446 0.120663928252862 no 3019 0.0226800388650941 4663 3372 An atypical antipsychotic.
SGTC_1926 methyl fluorone black 53.6 µM -2.00362053318595 0.120402693098672 no 3020 0.0225553623094319 4355 72721 Reacts with homocysteine.
SGTC_1290 0986-0249 10.2 µM -2.00555968110702 0.120184705259174 no 3021 0.022451623620533 4588 53329
SGTC_2274 7947094 46.08 µM -2.00895926234497 0.119803215325938 no 3022 0.0222707270978787 4666 2971028
SGTC_1610 st001799 48.1 µM -2.01166234757372 0.119500493850956 no 3023 0.0221277711246415 4654 621897
SGTC_1162 k048-0130 20.1 µM -2.01580138429715 0.119038005071282 no 3024 0.0219103743805723 4693 6797406
SGTC_1664 st014217 9.02 µM -2.02113563960501 0.118443830534042 no 3025 0.0216328629530692 4732 3982782
SGTC_2888 9058547 12.99 µM -2.02203736262977 0.118343596481255 no 3026 0.0215862460600943 4645 16476514
SGTC_1581 himbacine 57.9 µM -2.02286420646041 0.118251738593454 no 3027 0.0215435748777577 4697 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1880 MG-132 525 µM -2.02641812346615 0.117857491640193 no 3028 0.0213609776418861 4660 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2029 5175081 200 µM -2.02646164169239 0.117852669800164 no 3029 0.021358749847542 4654 1380876
SGTC_2234 tolnaftate 200 µM -2.02836596195454 0.117641806896833 no 3030 0.0212614556861654 4758 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_756 0508-1999 28.3 µM -2.03723904622323 0.116662823118237 no 3031 0.0208130463707273 4698 6753853
SGTC_1415 3966-0071 78.1 µM -2.03828403690517 0.116547908711184 no 3032 0.0207607676819511 4624 2893185
SGTC_1718 roemerine 11.9335 µM -2.04196254574195 0.116144033165085 no 3033 0.0205776233631505 4317 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2338 7999974 200 µM -2.0489750442988 0.115376861811111 no 3034 0.0202322776304929 4657 315925
SGTC_219 mitoxanthrone 164.414 µM -2.05382104938324 0.114848814749372 no 3035 0.0199965074348612 4679 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_928 2764-0428 58.7 µM -2.05578150732824 0.114635681766804 no 3036 0.0199017906519483 4714 662578
SGTC_2405 ticlatone 3.52 µM -2.05751659532668 0.114447285009299 no 3037 0.0198182801310728 4526 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3241 9133421 49.47 µM -2.05765376876107 0.1144324000534 no 3038 0.0198116906200337 4764 17018221
SGTC_1264 0783-0040 158 µM -2.06122104781714 0.11404579152054 no 3039 0.019640978200937 4640 2855798
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.06612694330091 0.11351562975738 no 3040 0.019408247388184 4690 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_589 1227-0070 34.1 µM -2.06906071892695 0.113199428538492 no 3041 0.0192701946189138 4724 2841384
SGTC_29 0299-0004 12.984 µM -2.07008463055706 0.113089219802944 no 3042 0.0192222099488919 4641 16871 A napthoquinone isolated from Swertia calycina.
SGTC_135 0933-0004 26.348 µM -2.07082691717161 0.113009371665994 no 3043 0.0191874869094304 4641 21230617 YGL099W LSG1
SGTC_3282 9108498 15.4605 µM -2.07359018945738 0.112712478821072 no 3044 0.0190586935522305 4686 16459645
SGTC_2783 7738165 71.43 µM -2.07403678934015 0.112664547350015 no 3045 0.0190379471389719 4686 17201110
SGTC_322 k048-0136 19.3 µM -2.07942687438988 0.112087202533569 no 3046 0.0187890662637322 4729 6823282
SGTC_1522 st012842 45.6 µM -2.08100614918334 0.111918443982045 no 3047 0.0187166716085086 4555 3491067 YOR116C RPO31
SGTC_2686 alizarin 95.37 µM -2.08407618042693 0.111590905856688 no 3048 0.0185766191657908 4676 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2756 carbadox 75.1 µM -2.09447371241752 0.110486701376902 no 3049 0.0181089012022717 4628 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1016 4226-1401 38 µM -2.09934997081749 0.10997155592627 no 3050 0.0178930307045974 4709 2901613
SGTC_1984 st072354 53.1 µM -2.09998254177919 0.109904855355294 no 3051 0.0178651884522236 4630 5762938
SGTC_138 0850-0259 40.9225 µM -2.10850399679077 0.109009150886927 no 3052 0.0174937087032351 4641 6813004
SGTC_391 gliotoxin 8.33 µM -2.11029785261017 0.108821266097601 no 3053 0.0174163542250901 4718 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2224 6650123 117.647 µM -2.11881334035371 0.107932547248609 no 3054 0.0170531224455251 4762 2908370
SGTC_892 0929-0076 29 µM -2.12001409337853 0.10780765234347 no 3055 0.017002428393604 4706 5751038
SGTC_2504 purpurogallin 52.29 µM -2.12229675860359 0.107570510739503 no 3056 0.0169064127575739 4674 5281571 An antioxidant.
SGTC_1687 st020778 55.3625 µM -2.12502800514419 0.107287261138639 no 3057 0.0167921380810067 4740 4259299
SGTC_3339 9145883 14.936 µM -2.12787373131608 0.106992711603039 no 3058 0.016673777046649 4667 2030670
SGTC_412 gemfibrozil 100 µM -2.12952527854533 0.106822034403412 no 3059 0.0166054128723949 4687 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_203 k066-0004 30.888 µM -2.1406661054659 0.105675829425412 no 3060 0.0161504868562088 4743 6795412
SGTC_2032 5185112 25.99 µM -2.14237641484927 0.105500657466754 no 3061 0.0160816021068392 4634 5718189
SGTC_1274 0865-0114 173 µM -2.14388084127481 0.105346745978977 no 3062 0.0160212178369116 4716 870624
SGTC_324 1315-0088 19.6 µM -2.14513788571406 0.105218267711771 no 3063 0.0159709120529353 4716 6787421
SGTC_659 k018-0002 107 µM -2.1479711767919 0.104929102447707 no 3064 0.0158580226351756 4700 6797879 YHR007C ERG11
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.15155651770537 0.104564008319098 no 3065 0.015716149967337 4629 4330530
SGTC_531 3788-1495 174 µM -2.15273697594261 0.104444004238008 no 3066 0.0156696778806314 4707 2896655
SGTC_463 ikarugamyin 104 µM -2.15279305688199 0.10443830559569 no 3067 0.0156674730320134 4787 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_476 mead acid 10 µM -2.1565546685716 0.104056585115946 no 3068 0.0155201899191451 4765 5312531 An omega 9 fatty acid.
SGTC_722 3534-0461 190 µM -2.15896299279454 0.103812725172578 no 3069 0.0154265190537389 4717 658262
SGTC_2996 9066192 71.4286 µM -2.1607306871934 0.10363399754191 no 3070 0.0153580744896137 4688 6472854
SGTC_970 1315-0089 19.5 µM -2.16360622629701 0.103343735397355 no 3071 0.0152472916411344 4706 6811083 YLR033W RSC58
SGTC_455 paf C-16 10 µM -2.16919211995088 0.10278157284105 no 3072 0.0150340505757566 4691 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_117 lucigenin 22.078 µM -2.1763964764346 0.102059814420956 no 3073 0.0147628135229838 4677 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_254 nsc-64875 3.808 µM -2.17719299354809 0.101980243429534 no 3074 0.0147330854290782 4718 56993
SGTC_2054 5233173 129 µM -2.17758480653522 0.101941118407355 no 3075 0.0147184808526727 4718 6889
SGTC_3075 9116269 49.47 µM -2.18120063087149 0.1015805707935 no 3076 0.0145842900967812 4701 17015205 YNL244C SUI1
SGTC_1775 st081588 35.1725 µM -2.18489739811899 0.101212913004667 no 3077 0.0144481851696833 4701 1426443 YGL099W LSG1
SGTC_1286 0929-0070 131 µM -2.18857290598125 0.100848331800164 no 3078 0.0143139484402502 4741 1420408
SGTC_3 0833-0587 95.581 µM -2.1943883721965 0.10027344138582 no 3079 0.0141037505617169 4636 5382644
SGTC_2000 st075254 36.4 µM -2.19856343214572 0.0998621915981526 no 3080 0.0139544897714305 4680 17234175
SGTC_197 4544-0043 41.561 µM -2.19930239845145 0.0997895307925522 no 3081 0.0139282136421118 4743 896523
SGTC_347 4534-1311 26.2 µM -2.20282617034211 0.0994435777953403 no 3082 0.0138035014376307 4720 2862016
SGTC_407 eburnamonine 100 µM -2.21024838343599 0.0987177575344278 no 3083 0.0135439643732668 4633 3195
SGTC_2941 9056145 11.23 µM -2.21109618427365 0.0986350982267806 no 3084 0.0135145885688393 4701 2119517
SGTC_2507 purpurin 79.67 µM -2.21547198201733 0.0982092699873556 no 3085 0.0133638426919758 4704 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_540 1187-0821 17.3 µM -2.22356815357507 0.0974249493618796 no 3086 0.013088756601187 4686 847520
SGTC_1401 3807-4679 7.6 µM -2.22409131887667 0.0973744259623138 no 3087 0.013071150427076 4673 3291456
SGTC_2893 9048488 25.97 µM -2.22494080941557 0.0972924294548174 no 3088 0.0130426059768454 4727 6467338
SGTC_951 1171-0579 82.7 µM -2.22548021661767 0.0972403898380077 no 3089 0.0130245088830107 4668 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_140 0062-0056 502.533 µM -2.22691105990298 0.0971024473685228 no 3090 0.0129766092638435 4656 3758964
SGTC_712 r015-0009 80.6 µM -2.2273363200061 0.097061477265893 no 3091 0.0129624024383098 4737 6813872 YLR060W FRS1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.2302111420246 0.0967848459967151 no 3092 0.0128667144567834 4724 229346 A bile salt which induces apoptosis.
SGTC_3094 9117742 49.47 µM -2.23201427165676 0.0966116346022791 no 3093 0.0128070098508331 4697 17149698
SGTC_3066 9117245 49.47 µM -2.23262631581954 0.0965528924969666 no 3094 0.0127867986080426 4741 17176980
SGTC_2066 5222451 176 µM -2.23454834670974 0.0963685925045635 no 3095 0.0127235075814632 4691 2281147
SGTC_1602 st001878 87.6 µM -2.23522340965579 0.0963039233496956 no 3096 0.0127013426796509 4707 595405 YLR310C CDC25
SGTC_1986 st071812 45 µM -2.23841622722584 0.0959984924327275 no 3097 0.0125969623991107 4706 11838594
SGTC_2375 9072683 200 µM -2.23968733681658 0.0958770941546408 no 3098 0.0125556141206521 4745 16798029
SGTC_2912 7964298 10.93 µM -2.24597262221415 0.0952784725174674 no 3099 0.0123528807903617 4714 2975850
SGTC_965 1291-5240 308 µM -2.24886361210549 0.0950040553853123 no 3100 0.0122605873540686 4717 2834598
SGTC_2201 6605497 169.863 µM -2.24940974024069 0.0949522815219703 no 3101 0.0122432197393095 4726 670741
SGTC_469 w7 172 µM -2.25465310833075 0.0944562588639571 no 3102 0.012077555563969 4771 45115570 A P450 inhibitor.
SGTC_670 4204-0025 119 µM -2.25527363744816 0.0943976834721418 no 3103 0.0120580791507472 4720 719039
SGTC_3053 9095903 49.47 µM -2.25762336243248 0.0941761218645001 no 3104 0.011984575427309 4783 17174018
SGTC_2085 5307070 144.047 µM -2.26167691760749 0.0937948038583997 no 3105 0.0118586859325631 4695 2840351
SGTC_1002 4049-0206 172 µM -2.26194721862856 0.0937694172292728 no 3106 0.0118503322639739 4718 4662749
SGTC_33 0986-0033 35.816 µM -2.27130767965201 0.0928934107503242 no 3107 0.0115641793310626 4728 2848082
SGTC_181 1447-1644 8.07 µM -2.27234089809685 0.0927970881798135 no 3108 0.0115329642056773 4704 534600
SGTC_1269 0831-0796 3.05 µM -2.2728603975828 0.0927486853597581 no 3109 0.0115172969880147 4731 927758
SGTC_2323 6148992 148.28 µM -2.2801151397863 0.0920746961190918 no 3110 0.0113004302641338 4705 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_116 0155-0182 31.788 µM -2.28330816865631 0.0917792052387752 no 3111 0.0112061110945962 4635 771486
SGTC_2240 6690706 185.951 µM -2.28801850391576 0.091344582404433 no 3112 0.0110682217802478 4678 805876
SGTC_4 0960-0234 25.671 µM -2.28923881523003 0.0912322334764997 no 3113 0.011032740244555 4689 6821112
SGTC_196 k015-0023 18.111 µM -2.29149279731113 0.0910249882881337 no 3114 0.0109674639891444 4719 5211998
SGTC_2807 7945238 51.95 µM -2.29687160405859 0.0905318385149648 no 3115 0.0108130476499927 4704 17148797
SGTC_1070 indatraline 8.81 µM -2.31207928629697 0.089148274523738 no 3116 0.0103866572086394 4758 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2212 7123476 200 µM -2.31483370879437 0.0888993748318457 no 3117 0.0103110171938478 4761 1085715
SGTC_1761 st044296 37 µM -2.31639373632317 0.08875863472323 no 3118 0.0102683902217894 4755 1826700
SGTC_2482 5981709 142.65 µM -2.32147209061291 0.0883016329528582 no 3119 0.0101306893452273 4713 877755
SGTC_964 1287-0107 19.4 µM -2.32781744491931 0.0877330810423663 no 3120 0.00996089967692189 4726 51516812 YPR165W RHO1
SGTC_1300 1094-0077 113 µM -2.33281120734274 0.0872875572936593 no 3121 0.00982902810113925 4752 5532636
SGTC_1346 1488-2224 62.4 µM -2.33398659638673 0.0871829397250488 no 3122 0.00979821188719945 4747 3722427
SGTC_1829 berberine 14.4 µM -2.33457489377111 0.0871306124541725 no 3123 0.00978281968841966 4688 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.33817079494548 0.0868112776527731 no 3124 0.00968919494061455 4736 1241132 A phosphatase inhibitor.
SGTC_673 1082-0474 110 µM -2.36520716420184 0.0844382607991887 no 3125 0.00900999390464902 4729 3098046
SGTC_925 2064-1272 59.6 µM -2.36903934635301 0.0841058816808682 no 3126 0.00891717802863562 4730 6815817
SGTC_2781 5567276 71.43 µM -2.37330425300335 0.0837371267050313 no 3127 0.00881486748938484 4718 2853274
SGTC_783 0848-0141 92.7 µM -2.37599400821984 0.0835051887604569 no 3128 0.00875087350472096 4726 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1044 1222-0021 1.78 µM -2.37687961750945 0.0834289283002463 no 3129 0.00872989262513911 4702 4306703
SGTC_2553 4-methylesculetin 85.09 µM -2.38285101432083 0.082916092804427 no 3130 0.0085895726872905 4730 5319502
SGTC_1785 bathophenanthroline 24 µM -2.38914745617324 0.082377914205308 no 3131 0.00844376143231216 4695 72812 An iron chelator.
SGTC_924 2046-0044 21.3 µM -2.39369035509254 0.0819912534218245 no 3132 0.00833991180628231 4733 3623589
SGTC_2401 5128683 200 µM -2.40284940363304 0.0812158574033927 no 3133 0.00813394264615014 4721 708373
SGTC_1343 1487-0095 224 µM -2.40554207387174 0.0809889542944617 no 3134 0.00807424617136611 4735 4560101 YGL055W OLE1
SGTC_1457 k015-0032 57.3 µM -2.42753683905171 0.079153407503667 no 3135 0.00760087144836702 4757 4302660
SGTC_1076 itraconazole 331 nM -2.4282536482134 0.079094121514286 no 3136 0.00758586419626824 4764 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1707 st032323 6.317 µM -2.42955282242037 0.0789867548804126 no 3137 0.00755873093131198 4605 3132057 YMR211W DML1
SGTC_576 1073-0113 22.7 µM -2.42973950400516 0.0789713361759734 no 3138 0.00755483911625244 4768 5439563
SGTC_1877 wortmannin 25 µM -2.43349670894584 0.078661499558153 no 3139 0.00747688568277743 4760 312145 A covalent inhibitor of PI 3-kinase.
SGTC_300 r073-0011 5.04 µM -2.43498773601562 0.0785387981830334 no 3140 0.00744614721801331 4764 2735780
SGTC_2597 laccaic acid a 100 µM -2.43772826094352 0.0783136501203911 no 3141 0.00738993986282453 4729 5491415 A textile dye.
SGTC_1482 3346-2049 8.48 µM -2.45067125966273 0.0772569268185747 no 3142 0.00712950566411945 4762 3826804
SGTC_1147 3809-1045 12.3 µM -2.4577019890313 0.0766874659894596 no 3143 0.00699145765054945 4763 325925
SGTC_88 0180-0332 8.668 µM -2.45796169846515 0.0766664918670394 no 3144 0.00698640377068216 4778 3101745
SGTC_202 3594-0513 34.79 µM -2.46331188629374 0.0762353809611126 no 3145 0.00688300555236886 4787 708429
SGTC_1182 1222-0449 220 µM -2.46754337914579 0.0758957215983138 no 3146 0.00680218682772304 4755 658318
SGTC_288 1315-0019 35.1 µM -2.47371041502556 0.075402762684329 no 3147 0.00668590177641248 4766 6811474
SGTC_2276 7947513 42.08 µM -2.47413866945189 0.0753686212110428 no 3148 0.00667789228184759 4715 2105100
SGTC_1217 1183-1422 255 µM -2.47520705153542 0.0752834985862221 no 3149 0.00665794765973074 4761 2849664
SGTC_1350 1495-0454 146 µM -2.47737105501696 0.0751113076518782 no 3150 0.00661771118244814 4768 1069057
SGTC_1282 0886-0010 32.4 µM -2.48660248386042 0.0743801295795232 no 3151 0.00644847085720079 4765 2836211 YNL267W PIK1
SGTC_3120 9124077 49.47 µM -2.49336774511648 0.0738477449630124 no 3152 0.00632688573559646 4795 18774327 YGL155W CDC43
SGTC_2336 9001819 198.65 µM -2.49550617506945 0.0736800707916186 no 3153 0.00628887830206683 4730 2989602
SGTC_2773 thioridazine 9.09 µM -2.49644906989113 0.0736062309825417 no 3154 0.00627218405363014 4750 5452 An antipsychotic.
SGTC_1136 pergolide 1.05886 µM -2.49730155784747 0.0735395198120175 no 3155 0.00625712427473912 4724 47811 A dopamine receptor agonist.
SGTC_730 1436-0052 41.2 µM -2.49879522986602 0.0734227444710727 no 3156 0.00623081472781928 4770 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1094 duloxetine 25.4 µM -2.51106924414032 0.0724685260711663 no 3157 0.00601830421352186 4771 60834 A selective serotonin reuptake inhibitor.
SGTC_3159 9100096 49.47 µM -2.51414687414141 0.072230758218257 no 3158 0.00596603649029391 4716 25236875
SGTC_3351 9150312 21.596 µM -2.52981694304273 0.0710294008462547 no 3159 0.00570610251230933 4731 4904905
SGTC_2153 5569715 200 µM -2.53086616518195 0.0709495129244757 no 3160 0.00568906271079365 4778 2054701
SGTC_2034 5197015 53.07 µM -2.53249726384727 0.0708254579081843 no 3161 0.00566266268441894 4764 780676
SGTC_2173 5763948 167 µM -2.53344364332736 0.0707535564031275 no 3162 0.00564739504313614 4763 2867177
SGTC_1163 k060-0048 49.9 µM -2.54052157586473 0.0702175852119245 no 3163 0.00553436320152643 4770 6809982
SGTC_855 0428-0020 25 µM -2.5453834518752 0.0698512361925906 no 3164 0.00545788981744454 4771 6812414
SGTC_1947 st076332 61.6 µM -2.55154742594629 0.0693888891067838 no 3165 0.00536228634818863 4702 24208416
SGTC_2536 dehydroabietamide 32.04 µM -2.55273632521682 0.0692999839831127 no 3166 0.00534401871363749 4765 3983547
SGTC_782 0083-0095 30.5 µM -2.55369926924499 0.069228039987366 no 3167 0.00532926350117384 4754 3591729 An indicator and reagent.
SGTC_3350 9150499 3.57 µM -2.55581882613282 0.0690698852447346 no 3168 0.005296913051015 4771 4910996 YPR165W RHO1
SGTC_594 1487-1584 10.8 µM -2.55892758561331 0.068838423167949 no 3169 0.00524978049911789 4768 5013332
SGTC_1615 st002656 86.5 µM -2.56642725700273 0.0682824983314908 no 3170 0.00513760874506852 4769 1584458
SGTC_637 1181-0519 7.26 µM -2.57545370198463 0.0676180008891521 no 3171 0.00500543373007583 4772 6252091 YGR060W ERG25
SGTC_2248 tofa 1.1 µM -2.57693491746761 0.0675094374558033 no 3172 0.00498403585282255 4781 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_34 0469-0683 81.75 µM -2.57742733870931 0.0674733760387867 no 3173 0.00497694032449356 4769 3690923
SGTC_50 0929-0078 56.389 µM -2.58189863685786 0.0671466110355287 no 3174 0.00491292198025866 4701 1377751
SGTC_2835 9006588 71.43 µM -2.58469127812046 0.0669431448785465 no 3175 0.00487331125158076 4706 2345538
SGTC_331 k048-0133 24.5 µM -2.59363973173676 0.0662943903558532 no 3176 0.00474829702954727 4775 6813582
SGTC_917 harmaline 728.087 nM -2.60986189669974 0.0651307254886342 no 3177 0.00452893908028241 4722 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2047 4141938 200 µM -2.61167475238664 0.0650016746876889 no 3178 0.00450499633781268 4783 3807862
SGTC_1919 st067113 52.3 µM -2.62974162546892 0.0637263796085611 no 3179 0.00427248920775086 4734 1268243
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.63900312083837 0.0630802243544541 no 3180 0.00415751077182812 4771 368090
SGTC_2 0422-0095 29 µM -2.64124392358767 0.0629246574649461 no 3181 0.00413011123633421 4715 6790840
SGTC_1567 st069303 68.4 µM -2.64601616236816 0.0625943427935791 no 3182 0.00407229624732833 4759 5581319
SGTC_2326 6164455 177.58 µM -2.65355620541024 0.0620752088779864 no 3183 0.00398242523106934 4739 2888790
SGTC_1786 berberine 21.6 µM -2.65781167608207 0.0617837050994754 no 3184 0.00393249143306131 4712 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2129 girgensonine 121.053 µM -2.6594793923228 0.0616697568324847 no 3185 0.00391307587744315 4755 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3055 9094636 49.47 µM -2.66688244672687 0.0611659160024615 no 3186 0.0038279222484014 4767 25236176
SGTC_2556 citropten 84.59 µM -2.67048750032036 0.0609217289487812 no 3187 0.00378705957751689 4752 2775 A potential DNA crosslinker.
SGTC_3232 9132874 49.47 µM -2.67130490104439 0.0608664687328989 no 3188 0.00377784904344325 4765 3784940
SGTC_1359 1582-0056 520 nM -2.67955979890483 0.0603105921723745 no 3189 0.00368595172916715 4784 3661189
SGTC_483 fpl-64176 144 µM -2.693191525272 0.0594013530646886 no 3190 0.00353858007199803 4804 3423
SGTC_721 1187-1332 279 µM -2.69643486487306 0.0591866121675714 no 3191 0.0035043051499106 4783 25730
SGTC_2730 imipramine 71.33 µM -2.70010412783159 0.0589444054796002 no 3192 0.00346588884621959 4761 3696 A tricyclic antidepressant.
SGTC_2575 plumbagin 510 nM -2.70195103028131 0.0588227867141398 no 3193 0.00344669571370672 4721 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_609 0986-0026 86.3 µM -2.70306577384659 0.0587494760588067 no 3194 0.00343515748644196 4764 2848610
SGTC_227 fluconazole 33.516 µM -2.70796589768896 0.0584280715090876 no 3195 0.00338484890949138 4784 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1597 7-benzyloxygramine 47.5 µM -2.71137775892514 0.0582051003695205 no 3196 0.00335021209659859 4707 260807
SGTC_2698 st077697 67.5 µM -2.71597678632046 0.0579056043347435 no 3197 0.00330402756030852 4751 3154499
SGTC_854 0422-0053 192 µM -2.72005130947433 0.0576412780720331 no 3198 0.00326358936752048 4786 3596728
SGTC_1 0258-0098 57.368 µM -2.75181518800659 0.0556130673655908 no 3199 0.00296329784839484 4713 6790032 YDR047W HEM12
SGTC_1981 st071826 47 µM -2.75545790764636 0.0553841155027848 no 3200 0.00293050226601164 4780 11838600
SGTC_1743 st037606 46.3785 µM -2.75597953351103 0.0553513913313666 no 3201 0.00292583291867814 4752 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3000 9075062 71.4286 µM -2.76107106042583 0.0550327759669738 no 3202 0.00288060698180862 4773 17057871
SGTC_3175 9106517 49.47 µM -2.76431966076366 0.054830244895313 no 3203 0.00285208140625195 4777 41468073
SGTC_264 promethazine 12.5 mM -2.80157567372438 0.0525494437835408 no 3204 0.00254268563897593 4727 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2225 6654152 15.4 µM -2.81834487819934 0.0515477227601138 no 3205 0.00241359648228088 4786 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1048 3161-0300 24.5 µM -2.82354069619039 0.0512404467042413 no 3206 0.00237481978280009 4781 2165101
SGTC_3182 9108849 49.47 µM -2.83789897012003 0.0503988850108145 no 3207 0.00227057769562 4775 17133045
SGTC_2286 7945697 125 µM -2.8379222025806 0.0503975322980553 no 3208 0.00227041243909541 4750 1245733
SGTC_1001 4048-4355 44.4 µM -2.84589540100582 0.0499349979794326 no 3209 0.00221433697305223 4777 21824233
SGTC_291 SEC14.278 35.5 µM -2.84964381495009 0.0497187212873922 no 3210 0.0021884106745328 4790 1068044
SGTC_1045 1348-1485 165 µM -2.85121963782963 0.0496280225879516 no 3211 0.00217759372214953 4768 6810614
SGTC_1827 berberine 7.24 µM -2.85201818987827 0.0495821112345836 no 3212 0.0021721307303413 4743 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2171 5739187 198.077 µM -2.85750127151074 0.04926778575237 no 3213 0.00213495461752126 4778 2262761
SGTC_1547 harmine 94.2 µM -2.86446599844287 0.048870819286761 no 3214 0.00208856498538138 4737 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2140 5586273 200 µM -2.86643235723309 0.0487592071936129 no 3215 0.00207563431659915 4788 854421
SGTC_624 k048-0052 28 µM -2.87024920870823 0.0485431412496414 no 3216 0.00205074204019296 4788 6835531
SGTC_1773 st048542 73.5835 µM -2.87333461958142 0.0483690411325901 no 3217 0.0020308183386761 4779 3237138
SGTC_956 1185-0240 191 µM -2.87560066005897 0.0482414939043955 no 3218 0.00201629771126053 4770 1416193
SGTC_1515 3460-0031 42.1 µM -2.89235789296886 0.0473066223602204 no 3219 0.00191181056053872 4783 2876596
SGTC_1062 mesoridazine 14.2 µM -2.8973845844652 0.0470290361303542 no 3220 0.00188144081850343 4802 4078 A neuroleptic.
SGTC_1374 2889-5571 141 µM -2.91173497471953 0.0462437536853945 no 3221 0.00179713727200899 4784 2853281
SGTC_1506 4226-2149 212 µM -2.91260354255603 0.0461965638779672 no 3222 0.00179214674011152 4786 991114
SGTC_2325 6158266 200 µM -2.92535390216662 0.0455082700931232 no 3223 0.0017203234518825 4772 3623240
SGTC_1132 3456-3614 2.5 µM -2.92775001523819 0.045379847505415 no 3224 0.0017071221791657 4757 3125502
SGTC_900 1112-0045 141 µM -2.92853156733435 0.0453380223715675 no 3225 0.0017028362420618 4775 56211 YIL048W NEO1
SGTC_488 nitrendipine 139 µM -2.93312318329397 0.0450929256832112 no 3226 0.00167785360954544 4784 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2485 5633444 17.78 µM -2.94865355803806 0.0442718200128795 no 3227 0.0015958076826341 4766 5724239
SGTC_2157 5649910 96.377 µM -2.94870936914693 0.0442688911056635 no 3228 0.00159551954781482 4777 2858091
SGTC_471 1-acyl-paf 4 µM -2.94890648345179 0.0442585480079011 no 3229 0.00159450228940577 4785 16759367
SGTC_2259 7964009 200 µM -2.95105205196628 0.0441460904194498 no 3230 0.0015834677098037 4789 313134
SGTC_2655 perillic acid 100 µM -2.9564083917147 0.0438663490563913 no 3231 0.00155622337159845 4804 5702197 An apoptosis inducer.
SGTC_2725 haloperidol 53.21 µM -2.95669507564385 0.0438514170440201 no 3232 0.00155477731143008 4775 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1619 st003326 88.7 µM -2.96092488274646 0.043631582507517 no 3233 0.00153358368132354 4766 2849032
SGTC_2236 dapsone 200 µM -2.96365792461645 0.0434900124918156 no 3234 0.00152003012174344 4785 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1921 5740136 50 µM -2.96700478758452 0.0433171521907698 no 3235 0.00150358138242636 4768 1774243
SGTC_2870 9038528 12.99 µM -2.96948784429444 0.0431892649693294 no 3236 0.00149148306966368 4785 6463316
SGTC_1318 1280-3875 124 µM -2.9697677266598 0.0431748690659955 no 3237 0.00149012497016997 4796 373245
SGTC_1809 st050081 57.6 µM -2.99294354510171 0.0419961913555598 no 3238 0.00138150427082964 4794 5036894
SGTC_819 1013-0258 27.7 µM -3.04036983815889 0.0396653734267481 no 3239 0.00118143900019045 4793 5753198
SGTC_525 k781-2675 26.7 µM -3.04368368052698 0.0395065230611652 no 3240 0.00116850362950711 4776 3651118 YDL195W SEC31
SGTC_479 n-linoleoylglycine 10 µM -3.0450132446119 0.0394429355000857 no 3241 0.00116335031703282 4797 6433346 An anti-infammatory.
SGTC_1172 0370-0043 85 µM -3.05859288631828 0.0387982337319447 no 3242 0.00111189563886029 4787 376585
SGTC_1949 st076024 69.1 µM -3.0641671592427 0.0385360886119212 no 3243 0.00109138455010724 4772 2921930
SGTC_866 0495-0101 262 µM -3.07088229497079 0.0382222101132798 no 3244 0.00106713634464147 4787 635694
SGTC_1075 aripiprazole 15.2 µM -3.07093794720971 0.0382196175561446 no 3245 0.00106693746604513 4804 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1990 st072050 59.8 µM -3.09971343152076 0.0368981945919555 no 3246 0.00096853979652549 4795 17233948
SGTC_901 1112-0062 60.1 µM -3.10084457623072 0.0368470231327196 no 3247 0.000964847744560438 4796 1908457
SGTC_3248 9135562 49.47 µM -3.10656283417382 0.0365892243026718 no 3248 0.000946380393482654 4789 17650701
SGTC_3244 9134489 49.47 µM -3.12024604671971 0.0359783245035435 no 3249 0.000903500172178614 4796 16584271
SGTC_932 2857-0803 154 µM -3.12584455955433 0.0357307939723006 no 3250 0.000886476187861234 4782 674898
SGTC_646 4092-0839 27.3 µM -3.16923064351725 0.0338594955020208 no 3251 0.000764215269836799 4791 877796
SGTC_2691 st077356 60.2 µM -3.18296605701462 0.0332841494664553 no 3252 0.000728873510813065 4783 2839272
SGTC_3321 9137793 26.8275 µM -3.18417427528433 0.0332339274878353 no 3253 0.000725837924559727 4795 4904192
SGTC_771 0250-0039 27.3 µM -3.19747318964992 0.0326852455203802 no 3254 0.000693186490955151 4795 3005115
SGTC_2246 7293507 91.5585 µM -3.19871744101529 0.0326342949954575 no 3255 0.00069020195416937 4793 887656
SGTC_1174 0739-0097 51.1 µM -3.1993722634164 0.0326075071606357 no 3256 0.000688636021339187 4802 728447
SGTC_2759 disulfiram 3.38 µM -3.20038915099803 0.0325659437142181 no 3257 0.000686210745064928 4764 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2671 danthron 100 µM -3.25172298268677 0.0305238660826796 no 3258 0.000573538799500684 4799 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1405 3909-7894 12 µM -3.26730168785368 0.029925538278926 no 3259 0.00054288953502874 4803 7104060
SGTC_3040 9091894 49.47 µM -3.32027339455254 0.0279633935575922 no 3260 0.000449646666367547 4777 25236966
SGTC_2400 5203494 178.7 µM -3.33517120969294 0.027431271708445 no 3261 0.000426234481464496 4771 6777674
SGTC_1067 clotrimazole 1.36 µM -3.33852226349997 0.0273127488356782 no 3262 0.000421126403089783 4807 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3059 1327-0034 3 µM -3.35597925581892 0.026702203030964 no 3263 0.000395422502356898 4766 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3031 9088762 49.47 µM -3.35625456999349 0.0266926661719344 no 3264 0.000395029046331085 4801 205253
SGTC_2307 7538926 6.34 µM -3.3578746422933 0.0266366046155612 no 3265 0.000392721125002314 4783 96582
SGTC_3161 9100388 49.47 µM -3.36336793048638 0.0264472445690899 no 3266 0.000384988340702628 4807 25236368
SGTC_2459 5811157 9.22 µM -3.37145844460402 0.0261704045843448 no 3267 0.000373856590143247 4800 2870684 YBR192W RIM2
SGTC_1006 4099-6547 255 µM -3.39036569175982 0.0255328764909383 no 3268 0.000348997233845911 4803 3146833
SGTC_1899 st063254 59.6 µM -3.40464638567035 0.0250600157939313 no 3269 0.000331248907176545 4802 3093813
SGTC_677 0929-0063 136 µM -3.41806286463747 0.024622480533259 no 3270 0.000315342689836944 4808 1539583
SGTC_1135 dihydrocapsaicin 536.708 nM -3.48186967463654 0.0226284058932434 no 3271 0.000248962982326734 4786 107982 A Capsaicinoid.
SGTC_3035 9091303 49.47 µM -3.48760347193574 0.0224560776352027 no 3272 0.00024368514965797 4806 25237002
SGTC_1696 st025591 34.7925 µM -3.49753041916246 0.0221603418100226 no 3273 0.000234793578285427 4805 2787147
SGTC_768 0384-0033 77.3 µM -3.51167081791473 0.0217447625167941 no 3274 0.000222649594916969 4800 3965305 YMR134W ERG29
SGTC_3249 9135183 49.47 µM -3.51893580169757 0.0215338209035987 no 3275 0.000216640770606924 4793 4902779
SGTC_2070 5230947 200 µM -3.52056021095278 0.021486892874665 no 3276 0.000215318104869335 4807 2835538
SGTC_2202 7226349 200 µM -3.53152212415297 0.021172465696886 no 3277 0.000206587648380034 4809 844334
SGTC_1265 0819-1001 68.8 µM -3.5340920337533 0.0210993172635566 no 3278 0.00020458928667006 4785 3106768
SGTC_1846 st056244 14.8 µM -3.53599659370886 0.0210452450073339 no 3279 0.000203119965770776 4792 5393182
SGTC_3187 9109394 49.47 µM -3.55241846385702 0.020583858499022 no 3280 0.000190853647678313 4803 17098090
SGTC_299 1273-0059 1.44 µM -3.5584131676474 0.0204175807628045 no 3281 0.000186551046595895 4698 2848077
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -3.57111326257284 0.0200690702821137 no 3282 0.0001777335631778 4777 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1711 st032263 62.8 µM -3.58019827765756 0.0198228703226597 no 3283 0.000171666791924791 4806 3958979
SGTC_1962 st076595 64.5 µM -3.58934191856703 0.0195776746218323 no 3284 0.000165756895210967 4793 279619
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -3.61496986637208 0.0189041213696775 no 3285 0.000150191279359794 4802 2374 Ca(2+)-ATPase inhibitor.
SGTC_1766 st045414 44.774 µM -3.61642135655161 0.0188665705098043 no 3286 0.000149352006019854 4799 253960
SGTC_2666 tannic acid 100 µM -3.61885632605547 0.0188037190116537 no 3287 0.000147953927831176 4804 16134267 A thiamine antagonist.
SGTC_740 k014-0057 261 µM -3.6215924232761 0.0187333074542066 no 3288 0.000146397581788518 4803 4012779
SGTC_1922 5578187 25 µM -3.63104381254056 0.0184918063001982 no 3289 0.000141138627696268 4800 1350412
SGTC_408 cantharidin 100 µM -3.6368865480421 0.0183438432160643 no 3290 0.000137976700429479 4803 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_660 4031-1742 102 µM -3.65821748687541 0.0178121853382982 no 3291 0.000126987745230968 4787 6738706
SGTC_169 k015-0017 16.025 µM -3.66561251280023 0.0176309644057966 no 3292 0.00012337364874023 4780 1840002
SGTC_2943 9068529 45.32 µM -3.68313450475573 0.0172078455260599 no 3293 0.000115191759424382 4790 3270634
SGTC_1518 st038567 90.8 µM -3.68521724400013 0.0171581334837341 no 3294 0.000114253822846708 4801 77966
SGTC_590 k048-0076 22.4 µM -3.68538777426112 0.0171540686082922 no 3295 0.000114177344914303 4806 6832814
SGTC_1495 4469-0029 237 µM -3.70405643671366 0.0167140177287844 no 3296 0.000106089510217694 4807 793680
SGTC_422 cantharidin 155 µM -3.70663010531606 0.016654116245801 no 3297 0.000105017679396894 4788 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_824 1304-0008 100 µM -3.70860748720501 0.0166082180575526 no 3298 0.000104201095855526 4805 768245
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -3.71649487831711 0.0164262146266298 no 3299 0.000101002867041396 4799 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3219 9131112 49.47 µM -3.73856643168723 0.0159259579897593 no 3300 9.25362953471113e-05 4767 17612988 YMR079W SEC14
SGTC_3153 9100258 49.47 µM -3.76600915458499 0.0153222281245893 no 3301 8.29388561336002e-05 4786 25236848
SGTC_2089 5281248 129.67 µM -3.76827161476088 0.0152733435910747 no 3302 8.21908925483878e-05 4803 2737878
SGTC_2136 5328288 199.296 µM -3.77099562430971 0.015214664237794 no 3303 8.12987622556793e-05 4796 262395
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -3.77771654859809 0.0150707129640429 no 3304 7.91364342320927e-05 4799 279621
SGTC_695 3505-6186 243 µM -3.78106120949501 0.0149995129850613 no 3305 7.80806349427231e-05 4805 1819379
SGTC_601 0986-0029 62.9 µM -3.81020949061373 0.0143911615206815 no 3306 6.9424542655572e-05 4797 24747981
SGTC_2300 7976697 71.57 µM -3.82574648016996 0.0140756580641602 no 3307 6.51882057594656e-05 4783 2236109
SGTC_2196 6573537 42.6665 µM -3.84010110138009 0.0137894805268326 no 3308 6.14918262737306e-05 4806 2903087
SGTC_2389 9091542 195.52 µM -3.84448522560117 0.0137030839663737 no 3309 6.04028813415552e-05 4802 3626624 YOL127W RPL25
SGTC_706 4262-0057 46.9 µM -3.84449017201947 0.0137029867532173 no 3310 6.04016630644516e-05 4798 883298
SGTC_1679 SEC14.276 6.7 µM -3.84938557236632 0.0136070674848062 no 3311 5.92072426155119e-05 4795 1005053 YMR079W SEC14
SGTC_524 r073-0010 27.8 µM -3.85889649719991 0.0134223682657295 no 3312 5.69500800430484e-05 4804 2772106
SGTC_2784 7567673 72.73 µM -3.88667618365564 0.0128952392420654 no 3313 5.08130873410741e-05 4788 3471247
SGTC_2398 5228213 48.84 µM -3.94491310028734 0.011848004343631 no 3314 3.99144615165757e-05 4800 80771 YMR134W ERG29
SGTC_3319 9138450 16.7555 µM -3.96701996559646 0.0114702435368753 no 3315 3.63884489939229e-05 4804 2029690
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -4.00542020589533 0.0108388990894883 no 3316 3.09536649245483e-05 4802 1377
SGTC_1830 st055982 50.3 µM -4.00725592623018 0.0108094904351801 no 3317 3.07141444873951e-05 4806 455313 An antimicrobial agent.
SGTC_3027 9089541 49.47 µM -4.012013974568 0.0107335885446948 no 3318 3.01014676589483e-05 4803 9943819
SGTC_871 0574-0004 149 µM -4.02909257055607 0.0104649547714759 no 3319 2.79962839987959e-05 4795 9551173
SGTC_978 1416-0512 87.4 µM -4.12071926411587 0.00912151521472846 no 3320 1.88845711653856e-05 4803 6814003
SGTC_218 alverine citrate 93.75 µM -4.14007150733126 0.0088579139754294 no 3321 1.73598788030099e-05 4792 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2266 7929956 200 µM -4.14828021274853 0.00874813329476318 no 3322 1.67491115961483e-05 4798 2967153
SGTC_1573 oleylamine 1.06 µM -4.16743390438032 0.00849660519471953 no 3323 1.54023895640971e-05 4799 5356789 An amine of the fatty acid oleic acid.
SGTC_2363 9053361 176 µM -4.17032488439912 0.00845919706683756 no 3324 1.52082852768459e-05 4799 6469797 YMR079W SEC14
SGTC_2235 salicylic acid 500 µM -4.17645378006139 0.0083803693422952 no 3325 1.48044435478382e-05 4795 338 A COX inhibitor and kinase inhibitor.
SGTC_2399 5884133 200 µM -4.18978215834407 0.00821116712048794 no 3326 1.3961119201722e-05 4800 722445
SGTC_748 act1.228 77.9 µM -4.24549467754061 0.00753596725465177 no 3327 1.09055843348872e-05 4801 4421505 YNR035C ARC35
SGTC_1616 st002734 56.1 µM -4.27096446480258 0.00724392750358672 no 3328 9.73147110065501e-06 4797 4026101
SGTC_2068 5226020 147 µM -4.29848512660671 0.00693963266372403 no 3329 8.59847193546344e-06 4806 1810509
SGTC_1731 st035964 63 µM -4.34107124077438 0.00649098574491539 no 3330 7.08948691044703e-06 4798 6739575
SGTC_2675 theaflavin digallate 100 µM -4.36582628556847 0.00624215328241513 no 3331 6.33215501195516e-06 4807 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2836 9010338 19.48 µM -4.46553729726487 0.00532332119812865 no 3332 3.99340281600195e-06 4796 2994051
SGTC_3254 9136651 49.47 µM -4.48133468913646 0.00518935079220146 no 3333 3.70888389311939e-06 4803 16454030
SGTC_3204 9114183 49.47 µM -4.53210764540365 0.00477885659809604 no 3334 2.91990379642091e-06 4798 17027248
SGTC_2779 methotrexate 400 µM -4.55202384114053 0.00462591237193892 no 3335 2.65661564045566e-06 4805 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2832 7992762 51.95 µM -4.58056220492775 0.00441436849951835 no 3336 2.3186383034388e-06 4802 2985177
SGTC_3039 9090270 49.47 µM -4.72190865093101 0.00348881924210531 no 3337 1.168208116524e-06 4805 17173750
SGTC_1260 0700-1617 7.75 µM -4.77105618665498 0.00321039455913398 no 3338 9.16312030184111e-07 4805 2853078
SGTC_1884 5633444 25 µM -4.78538939907159 0.00313304976035518 no 3339 8.53280709572473e-07 4806 5724239
SGTC_3242 9133940 49.47 µM -4.82053908444677 0.00295042803575978 no 3340 7.15854010806513e-07 4810 17248444
SGTC_1564 D-Arginine 115 µM -4.88360353354496 0.00264666581615498 no 3341 5.20822077717398e-07 4804 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3043 9092303 49.47 µM -4.91130057119218 0.00252241937435685 no 3342 4.52371380820217e-07 4809 25236084
SGTC_1461 k072-0203 53.8 µM -4.92152040448557 0.00247792267034592 no 3343 4.29372234694916e-07 4674 5418714
SGTC_883 0850-0245 24.6 µM -5.0955996277998 0.00182138003492336 no 3344 1.73819569073851e-07 4808 6823229 YPR165W RHO1
SGTC_2250 alverine citrate 130 µM -5.12692232487398 0.00172162604139097 no 3345 1.47258476501504e-07 4798 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1239 0337-0584 35.4 µM -5.17046050130012 0.00159122203468138 no 3346 1.16758914696537e-07 4810 914301 YML130C ERO1
SGTC_3050 9093513 49.47 µM -5.26234129838067 0.00134508791131498 no 3347 7.11162107062468e-08 4809 25236664
SGTC_1904 st060225 78 µM -5.67753850987824 0.000610328541751227 yes 3348 6.83233851489734e-09 4807 66595
SGTC_1063 disulfiram 1.84 µM -5.89684319591411 0.000393913433320179 yes 3349 1.85260827311338e-09 4810 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2774 tamoxifen 10.92 µM -5.91177884772217 0.000382142579616597 yes 3350 1.69216366199213e-09 4806 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_438 sphingosine 6.67 µM -6.16480518689093 0.000226287628085483 yes 3351 3.52849837037557e-10 4809 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2447 5741742 33.78 µM -6.3207772127696 0.000162283346609478 yes 3352 1.30125503332636e-10 4810 1776504
SGTC_2775 cyproheptadine 69.59 µM -6.72516059013415 6.62634856291165e-05 yes 3353 8.76994436355031e-12 4807 2913 A selective serotonin reuptake inhibitor.
SGTC_2776 terbinafine 19.92 µM -7.72545778794279 5.85625236253997e-06 yes 3354 5.5726035444276e-15 4807 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1463 k081-0032 34.1 µM -10.9728470665505 2.74135745546557e-10 yes 3355 2.58104481540126e-28 4675 977755
SGTC_1462 k081-0014 26.5 µM -11.9836818890394 6.36413182146296e-12 yes 3356 2.16335817999359e-33 4675 3270634