SGTCid condition conc unit YVH1|YIR026C.score YVH1|YIR026C.strain.pval YVH1|YIR026C.strain.significant YVH1|YIR026C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2265 7929201 200 µM 9.2593361157084 2.7596702326597e-20 yes 1 1.02853610486541e-20 3 1265108
SGTC_832 4083-0019 164 µM 6.39821262668532 1.28507719572758e-10 yes 2 7.86031374674121e-11 15 1990758
SGTC_118 0083-0097 135.343 µM 6.39006395077397 1.35388452991217e-10 yes 3 8.29081965952061e-11 13 5207356
SGTC_756 0508-1999 28.3 µM 5.37867768584553 5.3611550582289e-08 yes 4 3.75174518159185e-08 5 6753853
SGTC_1574 spiramycin 23.7 µM 4.98438736389056 4.24079612764199e-07 yes 5 3.10792210892992e-07 10 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_800 3448-7362 155 µM 4.97722268328591 4.39720567245753e-07 yes 6 3.22515496521807e-07 89 15991913
SGTC_1136 pergolide 1.05886 µM 4.93909472168681 5.32756159060385e-07 yes 7 3.92430416067415e-07 15 47811 A dopamine receptor agonist.
SGTC_2561 acetosyringone 100 µM 4.9140850959079 6.03778882068031e-07 yes 8 4.45990020694354e-07 7 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3140 9094243 49.47 µM 4.89888918442048 6.51291441936079e-07 yes 9 4.81899898200586e-07 16 19291112
SGTC_2315 7733312 200 µM 4.84158619527616 8.64923227943355e-07 yes 10 6.4403390297449e-07 10 726316
SGTC_2453 5731132 22.18 µM 4.76585419824783 1.25238094680487e-06 yes 11 9.40276085494609e-07 8 1362040
SGTC_1148 3909-7663 27.7 µM 4.7283476234422 1.50135244919327e-06 yes 12 1.13177202204601e-06 5 4084526
SGTC_2339 9000433 200 µM 4.56496082414803 3.25687137124014e-06 yes 13 2.49793813230693e-06 18 2988954
SGTC_69 0096-0274 206.684 µM 4.41596801158846 6.45623950457357e-06 yes 14 5.02794777913473e-06 28 6741392
SGTC_2531 methyl deoxycholate 70.07 µM 4.29883517514287 1.08956972159435e-05 yes 15 8.58490481695837e-06 17 16667744 Haematoxylin.
SGTC_791 1348-1292 225 µM 4.27575489519545 1.20608886724224e-05 yes 16 9.52453556718364e-06 27 5437054
SGTC_1696 st025591 34.7925 µM 4.26662947800146 1.25535124279554e-05 yes 17 9.92241702781389e-06 20 2787147
SGTC_1746 st038117 42 µM 4.11116436746138 2.45335670896558e-05 yes 18 1.96834409100646e-05 28 2898218
SGTC_1781 st038725 66.3 µM 4.00065347543723 3.89626170553579e-05 yes 19 3.15839012735939e-05 98 4270275 YIL048W NEO1
SGTC_342 k048-0088 23.3 µM 3.97577865127037 4.31701574031981e-05 yes 20 3.50746754214231e-05 17 6820570
SGTC_1335 1486-0900 202 µM 3.92947104041888 5.21705252834057e-05 yes 21 4.25664641621728e-05 25 X1335
SGTC_958 1222-0007 33 µM 3.90929053851037 5.66231683818843e-05 yes 22 4.62837895488666e-05 26 7312461
SGTC_625 k213-0058 121 µM 3.90918595384101 5.66471510596178e-05 yes 23 4.63038297817283e-05 107 3655420
SGTC_1912 st060209 90.8 µM 3.87940882631012 6.3879223809607e-05 yes 24 5.23553196252535e-05 38 688787
SGTC_1447 4239-0816 81.9 µM 3.87150411179602 6.59404217366962e-05 yes 25 5.40829161979176e-05 30 1341554
SGTC_58 0957-0393 9 µM 3.86367255558609 6.80442262304281e-05 yes 26 5.58474630156145e-05 383 6997992
SGTC_961 1252-1571 372 µM 3.80846295670106 8.47701077851477e-05 yes 27 6.99166445079746e-05 33 6813498
SGTC_3068 9116768 49.47 µM 3.80382802420338 8.6337621639367e-05 yes 28 7.12385558899616e-05 21 41904888
SGTC_3029 9088683 49.47 µM 3.79342488567816 8.99557348325431e-05 yes 29 7.42917960479412e-05 26 25236615
SGTC_2908 7930301 100 µM 3.76757786424323 9.95717892731644e-05 yes 30 8.2419567369758e-05 33 2223178
SGTC_1483 3453-0561 55.9 µM 3.76405007339758 0.000100956791030497 yes 31 8.35916919813741e-05 25 4546991
SGTC_2177 5811945 192 µM 3.7245759315966 0.000117739414048431 yes 32 9.78219101528638e-05 32 5343475
SGTC_2688 kanamycin b 96.69 µM 3.64126936710489 0.000162110120060926 yes 33 0.000135648549190287 418 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1258 0671-0043 57.1 µM 3.63744459919098 0.000164482525416023 yes 34 0.00013767819717894 35 4298767
SGTC_1238 0333-0287 48.8 µM 3.60128853802756 0.000188571183148162 yes 35 0.000158321957371199 38 7226
SGTC_2461 5755302 26.15 µM 3.52601678478793 0.000249667585477473 yes 36 0.000210930115693054 51 2788904
SGTC_1916 st067606 49.2 µM 3.51665769436503 0.000258439249468444 yes 37 0.000218508488310641 60 19590279
SGTC_1207 2099-0101 141 µM 3.43348201219579 0.000350019546768604 yes 38 0.000297940870157072 37 5837381
SGTC_2003 4023581 200 µM 3.39691160809497 0.000399150746984231 yes 39 0.000340754885688645 57 16641307
SGTC_1181 1222-0449 220 µM 3.39460005597579 0.000402461820917976 yes 40 0.000343644605270626 44 658318
SGTC_1074 carmofur 3.8 µM 3.32959220897979 0.000506698403064853 yes 41 0.000434866303395271 49 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1394 3474-0001 65.7 µM 3.28348089230102 0.000595220205595994 yes 42 0.000512667976241036 63 5017666 YIL048W NEO1
SGTC_462 ag-879 158 µM 3.18969169716092 0.000820916664991768 yes 43 0.000712123226202226 65 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1340 1486-1359 257 µM 3.16130176510232 0.000903386122194199 yes 44 0.000785328437129656 49 4309068
SGTC_3302 9125395 16.351 µM 3.06483023369625 0.00124382571712358 no 45 0.00108896792309332 43 17599668
SGTC_2874 9043904 71.43 µM 3.05387739352345 0.00128912503567188 no 46 0.00112952192441009 44 4463428
SGTC_1252 0493-0875 34.8 µM 3.05023037348019 0.00130454015700548 no 47 0.00114332947114696 71 3960963
SGTC_214 4373-3496 70 µM 3.03110390706391 0.00138817806929264 no 48 0.00121830690215524 128 3779166
SGTC_3083 9117465 49.47 µM 2.99346764296868 0.00156721537993235 no 49 0.00137913377266359 83 16420915
SGTC_761 k216-0224 480 µM 2.97685905011378 0.00165272185194807 no 50 0.00145608930640319 72 1340404
SGTC_527 4476-4215 268 µM 2.9438782441794 0.00183523315670626 no 51 0.00162063742850465 92 4418754
SGTC_3284 9108171 64.8615 µM 2.92133990177297 0.00197030152870451 no 52 0.00174264676593395 71 8687505
SGTC_930 2810-3379 265 µM 2.91600951342316 0.00200353789659833 no 53 0.00177269845053008 52 1015764
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.91435642732973 0.00201394824959499 no 54 0.00178211355845178 59 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_490 phenamil 164 µM 2.85713798887932 0.00240597708419448 no 55 0.00213739976368522 35 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3094 9117742 49.47 µM 2.83857734956982 0.00254725019758897 no 56 0.00226575674820473 87 17149698
SGTC_786 4544-0069 423 µM 2.82565159483032 0.00265001795986365 no 57 0.00235922774944731 106 748821 YLR208W SEC13
SGTC_2264 7948757 110.76 µM 2.80066638868159 0.00285934356172796 no 58 0.00254986048147729 85 2971411
SGTC_3085 9117376 49.47 µM 2.79141491217693 0.002940559448572 no 59 0.00262390766914136 64 16480349
SGTC_924 2046-0044 21.3 µM 2.76220292434161 0.00321082977338103 no 60 0.00287063914672362 71 3623589
SGTC_159 3970-0959 50 µM 2.74604503554495 0.00336973907176503 no 61 0.00301592414683836 201 6615653
SGTC_3049 9092223 49.47 µM 2.73473145039205 0.00348517671317861 no 62 0.00312155936611353 91 8623917
SGTC_1631 benzylvanillin 81.9 µM 2.71224900306458 0.00372517209850426 no 63 0.00334141855101005 99 75506
SGTC_2782 7736369 71.43 µM 2.7081325325454 0.00377068642388619 no 64 0.00338314980536353 130 2950836 YOL077C BRX1
SGTC_838 0109-0203 71.4 µM 2.70244176696476 0.00383442820996095 no 65 0.0034416120279593 75 759422
SGTC_3045 9092950 49.47 µM 2.69013257322517 0.00397561700591914 no 66 0.00357118192984376 86 44120432
SGTC_103 0844-0104 51.839 µM 2.66947721322508 0.00422302518392665 no 67 0.00379847138606564 250 5375804
SGTC_1064 honokiol 6.76 µM 2.6543036471027 0.00441345302407279 no 68 0.00397361383510585 98 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1402 3909-7673 35.9 µM 2.63512994860287 0.00466503430020223 no 69 0.00420525386369692 85 5328014
SGTC_1189 1431-2119 7.28 µM 2.61520898026003 0.00493989855778893 no 70 0.00445864382808638 129 3107275
SGTC_1117 retinoic acid 1.10837 µM 2.56957397160979 0.00562462408519543 no 71 0.00509118252426674 87 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_59 0330-0160 1.33 µM 2.56639762087933 0.00567528056184433 no 72 0.00513804777796499 268 4293482
SGTC_3348 9149464 3.537 µM 2.55685247819343 0.0058299525163064 no 73 0.00528120003789892 97 1951442
SGTC_631 k072-0230 41.5 µM 2.55396263182598 0.00587751215502354 no 74 0.00532523430482675 101 5773147
SGTC_1059 3448-6867 171 µM 2.54652575673847 0.00600149043515331 no 75 0.00544005910031581 91 3934407
SGTC_1573 oleylamine 1.06 µM 2.54142420871568 0.00608787229482128 no 76 0.00552009396518635 131 5356789 An amine of the fatty acid oleic acid.
SGTC_1071 trifluoperazine 6.31 µM 2.53060976300794 0.00627463951635505 no 77 0.00569322261216059 109 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1913 st060213 96.1 µM 2.50500412106115 0.00673721686754552 no 78 0.00612249833262937 152 688959
SGTC_1094 duloxetine 25.4 µM 2.5020900846084 0.00679172464519095 no 79 0.0061731252692412 123 60834 A selective serotonin reuptake inhibitor.
SGTC_1442 4112-3290 3 µM 2.48749713505934 0.00707059140432199 no 80 0.00643227448655706 109 704353
SGTC_2912 7964298 10.93 µM 2.45526446780148 0.00772261155638963 no 81 0.00703904869966964 220 2975850
SGTC_911 3456-4043 236 µM 2.45378728210557 0.00775372174828212 no 82 0.00706802873882248 144 914281
SGTC_1341 1486-1360 280 µM 2.43259216950596 0.0082123981582843 no 83 0.00749558776601717 125 3976547
SGTC_3304 9125678 46.087 µM 2.40467043131924 0.00885292864719957 no 84 0.00809352819026034 172 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_851 0394-0702 453 µM 2.40245782998554 0.00890550996912975 no 85 0.00814265605346465 117 762646
SGTC_1006 4099-6547 255 µM 2.4002644401498 0.00895790463088488 no 86 0.00819161579054325 142 3146833
SGTC_2072 5231554 129 µM 2.38768112676866 0.00926373862529986 no 87 0.00847752282858894 89 789545
SGTC_2817 7995342 71.43 µM 2.38178299206679 0.0094102097334698 no 88 0.00861452354986131 123 18879975
SGTC_1503 4585-0012 61.3 µM 2.37811027840769 0.00950243582164524 no 89 0.00870081039712887 130 2922052
SGTC_2310 7668677 200 µM 2.36424150183779 0.0098578610912316 no 90 0.00903351541444847 158 2197143
SGTC_1638 st008370 60.6 µM 2.35851525110333 0.0100079650321855 no 91 0.00917410291489488 162 24207134
SGTC_3291 9121177 71.43 µM 2.35004268079668 0.0102337178653558 no 92 0.00938562925509826 121 17015612
SGTC_2349 9023730 187.07 µM 2.34633404379483 0.0103339244140388 no 93 0.00947955358569373 159 4126287
SGTC_714 4296-0578 26.1 µM 2.33763396889016 0.010572362105649 no 94 0.00970312211424861 44 1589775
SGTC_2709 st078560 56 µM 2.33598853449802 0.0106179925442122 no 95 0.00974591955278402 111 17250903
SGTC_3323 9138564 53.9225 µM 2.33409390358175 0.0106707459840264 no 96 0.00979540272798337 150 43912313 YNL103W MET4
SGTC_3258 9138477 49.47 µM 2.32823430265098 0.0108353458782291 no 97 0.00994983282577709 115 4970355
SGTC_188 3229-0966 278.469 µM 2.31721900422044 0.0111507618613725 no 98 0.0102459024031309 172 5722370
SGTC_33 0986-0033 35.816 µM 2.31326213304854 0.0112659976520098 no 99 0.0103541156458295 120 2848082
SGTC_1668 st014914 51.6 µM 2.30906817472055 0.0113892667759371 no 100 0.0104698992236029 96 2839556
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.30263769195784 0.0115805477549483 no 101 0.0106496182961742 195 676296 Flavone; oxidizing agent.
SGTC_1783 st039459 87.517 µM 2.29829054789597 0.0117114326408444 no 102 0.0107726290318967 157 729761
SGTC_2020 4017018 200 µM 2.28365220741359 0.0121616532894628 no 103 0.0111959894625471 144 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_529 4076-0302 30.3 µM 2.28130537414364 0.0122352111658517 no 104 0.0112651914699809 133 5816522
SGTC_2073 5212005 126 µM 2.26675269638065 0.0127000059091622 no 105 0.0117026686486303 89 691789
SGTC_2199 6590217 200 µM 2.2498692911574 0.0132583157195719 no 106 0.0122286219182976 73 703109
SGTC_1236 0330-0013 258 µM 2.24870707616131 0.0132975167794552 no 107 0.0122655693438604 128 4617066
SGTC_485 niflumic acid 177 µM 2.24631445156101 0.0133785343852953 no 108 0.0123419367754978 126 4488 A COX2 inhibitor.
SGTC_211 3455-0679 143.504 µM 2.24222933924311 0.0135178473561025 no 109 0.0124732769363652 165 748649
SGTC_488 nitrendipine 139 µM 2.24041741282649 0.0135800385619015 no 110 0.0125319184374795 181 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2666 tannic acid 100 µM 2.23678411779245 0.0137054894128331 no 111 0.0126502265350796 188 16134267 A thiamine antagonist.
SGTC_2512 diallyl trisulfide 49.23 µM 2.2332270946468 0.0138292740338959 no 112 0.0127669862170396 97 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1446 4239-0190 62 µM 2.23030496247558 0.0139316846505403 no 113 0.0128636019798892 200 1340085
SGTC_464 bw-b 70c 158 µM 2.22811805431399 0.0140087553765201 no 114 0.0129363218242875 202 5353454
SGTC_2140 5586273 200 µM 2.21774211337524 0.0143794510435065 no 115 0.0132862105237041 110 854421
SGTC_369 0957-0393 4.5 µM 2.20694406143957 0.0147741653501211 no 116 0.0136589838159122 155 6997992
SGTC_2826 7992541 19.48 µM 2.19971536181192 0.0150435818642636 no 117 0.0139135480993766 181 2985066
SGTC_1122 capsaicin 818.572 nM 2.17225408575077 0.016105905666314 no 118 0.0149182515757905 174 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_88 0180-0332 8.668 µM 2.17094844274368 0.0161579757684074 no 119 0.0149675349422328 171 3101745
SGTC_2964 9083345 53.42 µM 2.16786978605485 0.0162813264158586 no 120 0.0150842976362137 167 17741579
SGTC_668 1682-0499 62.6 µM 2.1657106338928 0.0163683162570729 no 121 0.0151666529666504 202 682214
SGTC_2062 5245942 200 µM 2.15039040276004 0.0169970563379371 no 122 0.0157621734243657 192 1376160
SGTC_1339 1486-1321 22.7 µM 2.14895506149699 0.017057006536293 no 123 0.0158189812029864 195 3469382
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.14856710245753 0.0170732414965719 no 124 0.0158343659130227 180 6708514
SGTC_1123 mangostin 811.285 nM 2.12819485434904 0.0179445167040883 no 125 0.0166604656463133 232 5281650 An antioxidant.
SGTC_1214 0358-0031 63.7 µM 2.11751768006385 0.0184161083348649 no 126 0.0171079682046961 198 4301366
SGTC_456 gingerol 170 µM 2.11565003825774 0.0184996741856605 no 127 0.0171872913696477 188 442793 A herb.
SGTC_2832 7992762 51.95 µM 2.11451181817321 0.0185507609495317 no 128 0.0172357882260666 177 2985177
SGTC_888 0916-0002 6.97 µM 2.10658138579514 0.0189100473603061 no 129 0.0175769408234697 189 2802138 YIL048W NEO1
SGTC_1742 st038235 28.8875 µM 2.10415495415266 0.019021152088267 no 130 0.0176824662296174 287 564103 YBR002C RER2
SGTC_1845 st056753 3.01 µM 2.09167821072903 0.01960125904454 no 131 0.0182336554696779 228 5375839
SGTC_2298 7976326 193.81 µM 2.08193031758482 0.0200648796306502 no 132 0.018674417529665 140 2235818
SGTC_2443 5493264 126.67 µM 2.07878731453073 0.0202163334916194 no 133 0.0188184516824103 183 5340055
SGTC_2011 4012611 177 µM 2.07073116264169 0.0206089729112695 no 134 0.0191919631632197 217 2049887
SGTC_1565 sinapyl alcohol 95.1 µM 2.0592330204656 0.0211805430506967 no 135 0.0197359606787424 214 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1848 st056003 16.4 µM 2.05397762155294 0.0214462197908448 no 136 0.019988928843987 191 146492
SGTC_1724 st037281 8.293 µM 2.04641555416848 0.0218334451953528 no 137 0.0203577515179568 245 574124 YDL195W SEC31
SGTC_1429 4049-0205 9.46 µM 2.0420924111417 0.022057458409239 no 138 0.0205711827619798 207 22774478
SGTC_758 0868-0029 16 µM 2.03956427394578 0.0221893562121251 no 139 0.0206968717079729 186 762687
SGTC_447 ml7 120 µM 2.03846536811863 0.0222468954356421 no 140 0.020751707392889 202 4216 Selective myosin light chain kinase inhibitor.
SGTC_2725 haloperidol 53.21 µM 2.03582806795149 0.0223854994999752 no 141 0.020883811461849 239 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1705 st027868 56.3335 µM 2.03494627716701 0.0224320044450568 no 142 0.0209281394347206 175 292948
SGTC_2335 9018011 154.17 µM 2.03341331422629 0.0225130456432219 no 143 0.0210053916627885 233 6458208
SGTC_2506 ethyl hematommate 54.16 µM 2.02421122391146 0.0230047265743576 no 144 0.0214742116137573 181 3940691 An allergen.
SGTC_747 3448-8087 38.7 µM 2.02399836404856 0.0230162061665555 no 145 0.0214851600363748 239 5168703
SGTC_1128 3448-9350 235 µM 2.02050882041786 0.0232050871399452 no 146 0.0216653180790417 221 619386
SGTC_2355 9061122 103.12 µM 2.01133478173834 0.0237078908508835 no 147 0.0221450535014642 188 5302957
SGTC_1338 1486-1223 76 µM 2.00627423198584 0.0239891447037395 no 148 0.0224134988461662 216 3444526
SGTC_1500 4488-1866 171 µM 2.00391133831936 0.0241214261134244 no 149 0.0225397793821024 213 2900003
SGTC_1927 st060202 13.8 µM 2.00361022878558 0.0241383270046925 no 150 0.0225559146420717 206 688887
SGTC_3180 9109287 49.47 µM 2.00159652017164 0.0242516097733574 no 151 0.0226640717875443 189 18891271
SGTC_433 pimozide 108 µM 2.00091281397861 0.0242901735939807 no 152 0.0227008932055567 160 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_830 4076-0286 57.8 µM 1.99678960091983 0.0245238328610141 no 153 0.0229240218577843 389 6866659
SGTC_212 3807-4682 38.772 µM 1.97887879826457 0.0255608312214686 no 154 0.0239148269374416 342 3125501 YBL034C STU1
SGTC_1633 st005664 67.9 µM 1.97678614637397 0.025684352803183 no 155 0.0240329041485197 259 2063822
SGTC_62 0180-0423 3.232 µM 1.9731937999765 0.0258975608799436 no 156 0.0242367432959802 225 30102 YGL099W LSG1
SGTC_2267 7931562 200 µM 1.96819313832371 0.0261968170816911 no 157 0.0245229097389341 206 934880
SGTC_2421 5690543 90.72 µM 1.95906443945847 0.026750565819376 no 158 0.0250526203411912 244 3397993
SGTC_3078 9116413 49.47 µM 1.95807132267926 0.0268113937745838 no 159 0.0251108221114168 227 17177322
SGTC_998 3996-0085 177 µM 1.95723300001827 0.0268628305130883 no 160 0.0251600403186462 244 715391
SGTC_2881 9058953 51.95 µM 1.95344149655782 0.0270964947856659 no 161 0.0253836515995935 275 17122249
SGTC_325 2810-4341 181 µM 1.95315430670545 0.0271142627240449 no 162 0.025400656790311 195 774970
SGTC_2176 5809774 33.9695 µM 1.95129525748325 0.0272295141775942 no 163 0.025510966454183 204 2870539
SGTC_2801 7907800 81.82 µM 1.94643765282999 0.0275325909404164 no 164 0.0258010951819915 258 6620925
SGTC_8 0354-0001 70 µM 1.94230167683322 0.0277928554977229 no 165 0.0260502950767521 338 4993152
SGTC_1027 k015-0025 8.67 µM 1.9379678437194 0.0280677666751294 no 166 0.026313572906384 239 3598955
SGTC_459 nigericin 15.3 µM 1.92965218034455 0.0286016019059836 no 167 0.0268249743818177 292 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_123 0083-0120 66.675 µM 1.92412183203352 0.0289612849783201 no 168 0.027169657065015 277 16001701
SGTC_654 1124-0271 80.9 µM 1.91561577549749 0.0295218341154374 no 169 0.0277070100329226 281 5403748
SGTC_13 0199-0087 65 µM 1.90946571517329 0.0299327086608022 no 170 0.0281010202236258 223 4589825
SGTC_1473 k844-0725 134 µM 1.90486325592643 0.0302432839277636 no 171 0.0283989243363981 274 54682906
SGTC_1801 st050089 28.441 µM 1.90292196536537 0.0303750812685733 no 172 0.0285253641750252 379 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1334 1486-0610 236 µM 1.89296879870033 0.0310583138558025 no 173 0.0291810094534571 265 3742339
SGTC_3033 9090887 49.47 µM 1.88801884044615 0.0314028082239128 no 174 0.0295117105962672 279 19325384
SGTC_1038 k292-0204 154 µM 1.88538253887241 0.0315875683134556 no 175 0.0296891048640115 243 4454212
SGTC_2558 carylophyllene oxide 100 µM 1.88477699304482 0.0316301334611509 no 176 0.0297299761960634 251 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2663 amphotericin b 100 µM 1.87313336769561 0.0324578501052755 no 177 0.0305249853309872 244 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_261 5-fluorouridine 15.376 µM 1.86716595158562 0.0328889365959743 no 178 0.0309392083814475 257 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2576 guaiol 23.12 µM 1.85525907554341 0.0337631954932398 no 179 0.0317796196213082 281 227829
SGTC_913 3487-1245 167 µM 1.84501363556224 0.034530686849832 no 180 0.0325177775541508 294 4016153
SGTC_2644 guaiazulene 100 µM 1.84406149888447 0.034602734012079 no 181 0.0325870890468782 216 3515 A coloring agent.
SGTC_962 1254-0300 21.5 µM 1.84108968968765 0.0348284021247985 no 182 0.0328042081665127 242 7340576
SGTC_2066 5222451 176 µM 1.84088270094061 0.034844164984771 no 183 0.0328193749966425 337 2281147
SGTC_483 fpl-64176 144 µM 1.83925713540482 0.0349681607540555 no 184 0.0329386872618786 181 3423
SGTC_2296 7971656 126.45 µM 1.82824392215822 0.035817802366408 no 185 0.0337564759217504 303 666570
SGTC_2760 etidronate 98.04 µM 1.82771778300683 0.0358588123634823 no 186 0.0337959589225279 295 3305 A chelator and antioxidant.
SGTC_2305 7443522 69.23 µM 1.82207492239879 0.0363010694204279 no 187 0.0342218091157392 275 5415886
SGTC_1465 k213-0056 144 µM 1.81859946969555 0.036575671610829 no 188 0.0344862794008527 286 24048857 YMR208W ERG12
SGTC_2130 NSC 7 2.4545 µM 1.80875687412051 0.0373625867914329 no 189 0.0352443914415413 304 21448
SGTC_2585 alliin 100 µM 1.80872283736001 0.0373653318354265 no 190 0.0352470366044792 306 87310 A garlic compound which reacts with lipids.
SGTC_1219 1469-0211 33.1 µM 1.80560231716042 0.0376177006537916 no 191 0.0354902402387049 248 6822282
SGTC_2365 9042475 200 µM 1.80533726848579 0.0376392001569226 no 192 0.0355109605486077 306 6464479
SGTC_792 4534-1957 155 µM 1.79959475684627 0.0381074739999455 no 193 0.035962324794843 264 1717904
SGTC_22 0964-0034 14.468 µM 1.79561351395332 0.0384349058318074 no 194 0.036278002559386 346 138402
SGTC_599 1935-0052 86.5 µM 1.79279396051585 0.0386681804383379 no 195 0.0365029377845094 305 9557311
SGTC_2378 9074213 121.43 µM 1.79106497327604 0.0388117971728898 no 196 0.0366414345872687 307 657714
SGTC_504 lovastatin 124 µM 1.79092030241183 0.0388238337969305 no 197 0.036653042597704 235 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_900 1112-0045 141 µM 1.78357481699115 0.0394389860087565 no 198 0.0372463903494508 211 56211 YIL048W NEO1
SGTC_50 0929-0078 56.389 µM 1.78310780456125 0.0394783628347809 no 199 0.037284378118662 304 1377751
SGTC_732 3970-1727 52.7 µM 1.78084601166383 0.0396695219065186 no 200 0.0374688052023822 249 1275699
SGTC_3133 9127736 49.47 µM 1.77942989502631 0.0397895899625775 no 201 0.037584654446193 277 27243420
SGTC_3151 9099821 49.47 µM 1.77649869552873 0.0400390557897816 no 202 0.0378253783684195 268 17174189
SGTC_3014 9081533 49.47 µM 1.77218297228328 0.0404086660453694 no 203 0.0381820946149019 280 21367265
SGTC_965 1291-5240 308 µM 1.75756877914822 0.0416808864199523 no 204 0.0394104547379463 314 2834598
SGTC_3270 9137563 49.47 µM 1.75378432971943 0.0420155725271303 no 205 0.0397337345765482 253 17015724
SGTC_1217 1183-1422 255 µM 1.75092400401741 0.042269972460582 no 206 0.0399795007055895 293 2849664
SGTC_2354 9060492 162 µM 1.73900065282949 0.0433439020221857 no 207 0.0410173240460502 337 6471895
SGTC_517 1365-0151 113 µM 1.73723846125479 0.043504474079733 no 208 0.0411725443552303 306 768657
SGTC_1604 st002052 72.4 µM 1.73482835000691 0.0437248620567323 no 209 0.0413856065565006 317 6254834 YHR062C RPP1
SGTC_2366 9070441 60.58 µM 1.7284208591564 0.044315165785267 no 210 0.0419563992187375 331 6837235
SGTC_2658 polymyxin b sulfate 77.05 µM 1.7203532690385 0.0450675258135709 no 211 0.0426841229889721 324 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_117 lucigenin 22.078 µM 1.71925664735197 0.045170582565015 no 212 0.042783825070704 408 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_377 3970-0964 33.1 µM 1.71882714825574 0.0452109970604538 no 213 0.0428229253103407 420 16481235
SGTC_675 1309-0189 238 µM 1.71008484279456 0.0460399609101799 no 214 0.0436250926017975 307 4246530
SGTC_2786 7743617 45.45 µM 1.70996075313086 0.0460518146520564 no 215 0.043636565377309 262 583674
SGTC_2262 9014885 67.46 µM 1.70985208645075 0.0460621971172617 no 216 0.0436466142122537 213 6457424
SGTC_630 4356-0227 183 µM 1.70741269694813 0.0462957617666328 no 217 0.0438726860242188 283 779312
SGTC_26 0302-0163 425.158 µM 1.70326953824002 0.0466946357754654 no 218 0.0442588192354726 284 3100915
SGTC_1702 st027038 51 µM 1.70068382294758 0.0469449643795566 no 219 0.0445011872136123 343 5521182
SGTC_1455 4262-0120 131 µM 1.70050827837374 0.0469619981616824 no 220 0.0445176802952471 330 1529587
SGTC_419 nsc-638432 893 µM 1.69982888274954 0.0470279693142361 no 221 0.0445815585190032 324 368090
SGTC_2636 apigenin dimethyl ether 100 µM 1.6990792684253 0.047100845097417 no 222 0.0446521245070991 379 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1414 3917-0015 5.4 µM 1.69324587195939 0.0476710528074805 no 223 0.0452043381964234 275 6618702
SGTC_1177 0983-0204 23.6 µM 1.68526840140687 0.0484597762941272 no 224 0.0459683996417761 334 766818
SGTC_645 0845-0943 5.41 µM 1.68244385820943 0.0487415245248015 no 225 0.0462414014106192 316 1885106
SGTC_1902 st060212 70.5 µM 1.67995138021563 0.0489912353125902 no 226 0.0464833878998515 338 688944
SGTC_1030 k029-0042 36.7 µM 1.67958030393667 0.0490284991230027 no 227 0.0465195012454166 376 6080581
SGTC_1295 1013-0063 9.78 µM 1.67563221303362 0.0494263734703347 no 228 0.0469051275166861 339 6826038
SGTC_3089 9117425 49.47 µM 1.6699546631793 0.0500030500828917 no 229 0.0474641669390634 339 9401657
SGTC_1169 aniline yellow 25.8 µM 1.66619430416045 0.0503879396312465 no 230 0.0478373600431542 289 6051 A DNA damaging agent.
SGTC_2852 9023854 51.95 µM 1.66445354672474 0.0505669115197889 no 231 0.0480109134561221 348 19798528
SGTC_1411 3909-8223 150 µM 1.65610976910503 0.0514317986558696 no 232 0.048849795676019 349 X1411
SGTC_1197 1601-0112 267 µM 1.65582322503896 0.0514617084908992 no 233 0.0488788114985477 371 7350313
SGTC_581 0958-0271 211 µM 1.65536931603474 0.0515091164018985 no 234 0.0489248030963326 434 4591145
SGTC_427 1354-0053 47.3 µM 1.65503860345149 0.0515436790943931 no 235 0.0489583337840296 362 6813657
SGTC_2846 9008642 19.48 µM 1.65367945797435 0.0516859167311836 no 236 0.0490963292949206 319 2992898
SGTC_1765 st044815 90.4 µM 1.65303589541265 0.0517533757696562 no 237 0.0491617791930868 356 645695
SGTC_810 3825-7150 143 µM 1.64307573173242 0.0528063610606472 no 238 0.0501836326399695 344 22330411 YGL099W LSG1
SGTC_2095 5432005 200 µM 1.64284591211687 0.0528308566491742 no 239 0.0502074091010336 308 783734
SGTC_274 sirtinol 40.1 µM 1.63964092848903 0.0531734037478622 no 240 0.050539923934278 337 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2805 7950783 58.44 µM 1.63570904772965 0.0535960437634125 no 241 0.0509502474954378 415 1178958 YDL195W SEC31
SGTC_3307 9126885 69.2785 µM 1.63436784906545 0.0537408171254599 no 242 0.0510908174478711 393 24824909
SGTC_177 1327-0068 8.361 µM 1.63089861142387 0.0541167348390136 no 243 0.0514558574048376 394 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1404 3909-7820 48.3 µM 1.63047997241734 0.0541622378662387 no 244 0.0515000473237643 326 23741373
SGTC_1874 staurosporine 7.6 µM 1.62634182050105 0.0546136555561703 no 245 0.0519384799664703 364 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2152 5568786 200 µM 1.62110723323402 0.0551889357562136 no 246 0.0524973214965451 357 5399883
SGTC_2260 7964312 200 µM 1.6176898187329 0.055567084373862 no 247 0.052864730623192 324 231951
SGTC_2774 tamoxifen 10.92 µM 1.61741280000611 0.0555978268416558 no 248 0.0528946022908857 357 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1275 0867-0008 21.1 µM 1.61001784362462 0.0564234637724906 no 249 0.0536969804594285 373 3422836
SGTC_3065 9113888 49.47 µM 1.60439995670755 0.0570571285609504 no 250 0.054312960279289 332 16648368
SGTC_1235 benzylparaben 21.5 µM 1.60294257784323 0.0572224241975785 no 251 0.0544736661239296 346 7180
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.60230951510475 0.0572943433619947 no 252 0.0545435913100445 414 4174840
SGTC_3031 9088762 49.47 µM 1.59975593970904 0.0575851649412718 no 253 0.0548263683568002 377 205253
SGTC_3149 9097855 49.47 µM 1.59922723656422 0.0576455227106938 no 254 0.0548850602684559 341 25236625 YMR079W SEC14
SGTC_2529 gangaleoidin 93.61 µM 1.59860131871864 0.057717043000094 no 255 0.0549546082700076 317 4565183
SGTC_1437 4092-1038 11.6 µM 1.59815721258003 0.0577678309392633 no 256 0.0550039967365399 376 3977136
SGTC_3336 9143619 71.43 µM 1.5929238946528 0.0583689628107828 no 257 0.055588632578151 391 45595730
SGTC_1185 1319-0113 81.3 µM 1.58926693870986 0.0587919319548517 no 258 0.0560000697709137 333 4672763
SGTC_1271 0832-2808 169 µM 1.58822406603385 0.0589129919722424 no 259 0.0561178405014595 384 3663794
SGTC_2702 st077768 96.8 µM 1.58676576256056 0.059082604411928 no 260 0.0562828528951718 355 6484119
SGTC_2854 9024559 71.43 µM 1.58441642525946 0.0593566565719624 no 261 0.0565494932658801 390 3163529
SGTC_1516 st013856 110 µM 1.57299242293044 0.0607035065480103 no 262 0.0578602863500103 345 5281404 A mutagen and neurotoxin.
SGTC_31 0508-1974 57.237 µM 1.56575539864312 0.0615690177361875 no 263 0.0587029457256428 372 6810525
SGTC_2996 9066192 71.4286 µM 1.56540523543313 0.0616111386386386 no 264 0.0587439608124415 407 6472854
SGTC_2776 terbinafine 19.92 µM 1.56316838953999 0.0618807385499591 no 265 0.0590064965515497 407 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2540 epiandrosterone 100 µM 1.56158413901765 0.062072239583272 no 266 0.0591929941831512 529 441302 A steroid.
SGTC_1673 st016611 27.3 µM 1.5611621859788 0.0621233223203146 no 267 0.0592427442808138 417 5226799
SGTC_1667 st014849 34.6 µM 1.55671419334401 0.0626638050016984 no 268 0.0597691786591964 383 5348460
SGTC_1137 ixabepilone 100 µM 1.55630333628557 0.0627139132294353 no 269 0.0598179892382694 429 154225 A novel microtubule stabilizer.
SGTC_691 1548-0686 185 µM 1.55460659529444 0.0629211790072779 no 270 0.0600198960348478 430 46495133
SGTC_317 4495-0002 170 µM 1.55422998292716 0.0629672564664276 no 271 0.0600647840044558 341 15991618
SGTC_2972 9093619 59.92 µM 1.55292777511669 0.0631267805052649 no 272 0.0602201951751279 391 25236256
SGTC_1017 4239-0030 168 µM 1.54836545086227 0.0636881617075801 no 273 0.0607671672246105 435 1149593
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.5448849994638 0.0641190272086905 no 274 0.0611870412187918 391 16623 A steroid.
SGTC_1557 sumaresinolic acid 42.3 µM 1.54478674640005 0.0641312233391965 no 275 0.0611989270729123 382 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3178 9107506 49.47 µM 1.54258287703105 0.0644052633064072 no 276 0.0614660076090172 402 8897194
SGTC_600 1495-0418 41.6 µM 1.53877416197629 0.0648810015948517 no 277 0.061929719902207 381 5377768
SGTC_1850 st056238 17 µM 1.53841501360386 0.0649260024248173 no 278 0.0619735868183851 442 5393177
SGTC_303 1348-1668 34.2 µM 1.53813089687879 0.0649616190482604 no 279 0.0620083064328798 365 5380509
SGTC_1847 st056231 15 µM 1.53775247237067 0.0650090815638349 no 280 0.0620545742102246 480 5393180
SGTC_1457 k015-0032 57.3 µM 1.53548114526128 0.0652945202945256 no 281 0.0623328425001976 407 4302660
SGTC_1867 st057372 64 µM 1.53381034368436 0.0655051106600183 no 282 0.062538158780377 390 688837
SGTC_2689 tacrolimus 100 µM 1.52932214401781 0.0660734181855707 no 283 0.0630923013235615 416 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3026 9090633 49.47 µM 1.51864902162271 0.0674402154347686 no 284 0.0644254324041497 411 25236842
SGTC_2232 chlorophetanol 41.5365 µM 1.51622664411815 0.0677534459835041 no 285 0.0647310265111537 558 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1096 rimcazole 32.2 µM 1.51613435276751 0.0677654020934594 no 286 0.0647426917134005 369 18528119 A dopamine reuptake inhibitor.
SGTC_1721 st082152 9.2685 µM 1.51477003540554 0.0679423361103559 no 287 0.0649153256488305 380 5296051
SGTC_770 0389-1121 67.2 µM 1.51023224345551 0.0685333951162367 no 288 0.0654920869787612 466 6753108
SGTC_522 1273-0010 11.6 µM 1.50282434785835 0.069506804777226 no 289 0.066442172782269 405 5705015
SGTC_48 0382-0018 55 µM 1.50048965450477 0.0698157836731867 no 290 0.066743805681528 368 762596
SGTC_1301 naphtanilide LB 4.81 µM 1.4999494446627 0.0698874267063309 no 291 0.0668137493228671 440 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_87 0100-0052 35.5 µM 1.49677365416548 0.0703097468800659 no 292 0.0672260818710188 656 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2941 9056145 11.23 µM 1.49610495043678 0.0703989214520416 no 293 0.0673131540399071 339 2119517
SGTC_2082 5219693 150 µM 1.49539026549733 0.0704943239264742 no 294 0.0674063097915531 434 2834649
SGTC_2240 6690706 185.951 µM 1.49059232157445 0.0711373711583286 no 295 0.0680342807369369 359 805876
SGTC_2192 5915882 198.485 µM 1.48958340660484 0.0712731629598316 no 296 0.0681669038463988 365 2876149
SGTC_1331 1472-0049 76.2 µM 1.48458946370031 0.0719482392135616 no 297 0.068826304110261 423 24051409
SGTC_41 0478-0632 82.643 µM 1.48299226374081 0.0721651787343783 no 298 0.0690382331034376 510 3750424
SGTC_720 r052-1644 49.9 µM 1.47890426153436 0.0727227149258609 no 299 0.0695829521173835 377 1422863 YOR257W CDC31
SGTC_1944 st076371 56.9 µM 1.47737204859052 0.0729325312664563 no 300 0.0697879672343871 429 24208455
SGTC_814 3342-0569 96 µM 1.47466747793566 0.0733040169238663 no 301 0.0701509818551886 475 4346283
SGTC_2657 nystatin 74.44 µM 1.47277324709122 0.0735650592400646 no 302 0.0704060941797966 444 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2172 5754775 163.918 µM 1.47138743285422 0.0737564868900027 no 303 0.0705931850506364 420 2263357
SGTC_583 1488-1091 88.9 µM 1.47006273448449 0.0739398280850911 no 304 0.0707723820011159 529 4303273
SGTC_1475 4092-1048 11.7 µM 1.46887947933889 0.0741038874919129 no 305 0.0709327407338132 469 2881759
SGTC_1729 st035615 45.989 µM 1.46835061087566 0.0741773054453821 no 306 0.0710045049632113 439 17385451
SGTC_1073 triclabendazole 3.09 µM 1.4660643450855 0.0744953260746208 no 307 0.0713153790399941 504 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2835 9006588 71.43 µM 1.46538367956093 0.0745902077451064 no 308 0.0714081338055629 456 2345538
SGTC_1367 1812-0510 76.9 µM 1.46514496646537 0.0746235050993495 no 309 0.0714406853265475 430 1142582 YDR527W RBA50
SGTC_2726 cimetidine 79.27 µM 1.46086975861936 0.0752217632907776 no 310 0.0720255936149498 360 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.46065406557127 0.0752520432674913 no 311 0.0720552004459112 423 5355888
SGTC_120 rhodamine 6G 52.259 µM 1.45693183254713 0.0757760523470449 no 312 0.0725675989888372 537 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3 0833-0587 95.581 µM 1.45500629643998 0.0760482142124035 no 313 0.072833759189756 423 5382644
SGTC_2722 naftopidil 47.16 µM 1.45354831266987 0.076254785227466 no 314 0.0730357879585775 447 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_168 3970-0862 530.542 µM 1.44622345247541 0.0772990576403403 no 315 0.074057268885184 658 3135186
SGTC_3191 9110352 49.47 µM 1.44546393201145 0.0774079576912176 no 316 0.0741638084873623 403 17122424
SGTC_1871 st057448 67.3 µM 1.44335101573081 0.0777115206066008 no 317 0.0744608077301676 475 691747
SGTC_1493 4348-0038 111 µM 1.44301968583641 0.077759204662154 no 318 0.0745074629135012 485 800424
SGTC_1325 1431-0015 227 µM 1.4428651705485 0.0777814496548568 no 319 0.0745292281291862 418 1103340
SGTC_1025 k007-0731 70 µM 1.441756320828 0.0779412283647481 no 320 0.0746855644904042 439 6256118
SGTC_684 1140-0066 328 µM 1.43888428366173 0.0783562298452721 no 321 0.0750916555505625 497 6813534
SGTC_1151 3909-8316 15.3 µM 1.43873083983341 0.0783784491165522 no 322 0.0751133989976485 463 800431
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.43831439001994 0.0784387767688674 no 323 0.0751724353724605 464 688798
SGTC_1296 1068-0102 11.9 µM 1.43715689152849 0.0786066389377258 no 324 0.0753367094311471 451 767053
SGTC_1579 chlormadinone acetate 49.4 µM 1.43617227265774 0.0787496440355653 no 325 0.0754766634010452 468 45114258 A steroidal progestin.
SGTC_1041 0206-0046 107 µM 1.43306299897666 0.0792025261997529 no 326 0.075919917169754 454 50494
SGTC_999 SEC7.066 22.7 µM 1.43028255808918 0.0796091798407482 no 327 0.0763179693565339 502 740511 YDR170C SEC7
SGTC_815 1582-0027 36.9 µM 1.43001979732428 0.0796476914904923 no 328 0.0763556685708309 467 3128206
SGTC_438 sphingosine 6.67 µM 1.42955007209636 0.0797165720974948 no 329 0.0764230970116102 373 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2731 amoxapine 43.43 µM 1.42925065449447 0.0797605022689973 no 330 0.0764661016522712 291 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_233 rapamycin 362 pM 1.42315940144359 0.0806581835417617 no 331 0.0773449758516335 455 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1131 3454-3128 32.3 µM 1.42191299713533 0.0808428056509126 no 332 0.0775257548073087 529 710982
SGTC_1969 st069479 40.1 µM 1.41975334584421 0.081163456428111 no 333 0.0778397508121915 399 3895485
SGTC_2367 9070478 135.38 µM 1.41762791293317 0.0814799627484627 no 334 0.0781497131781288 497 572802
SGTC_1484 3473-2379 286 µM 1.41683264510492 0.0815986281112914 no 335 0.0782659313957504 560 671917
SGTC_1337 1486-1011 40.3 µM 1.41567046024592 0.0817722770474642 no 336 0.0784360055094275 450 X1337
SGTC_1155 4088-0394 48.2 µM 1.41305425389663 0.0821641990498674 no 337 0.0788198862384041 486 2326248
SGTC_717 1532-0246 73.2 µM 1.40897711568521 0.0827777949290621 no 338 0.0794209674929564 488 9561992
SGTC_871 0574-0004 149 µM 1.40794809948235 0.0829332020373637 no 339 0.0795732194154385 518 9551173
SGTC_413 propylparaben 100 µM 1.40667071635088 0.0831264239518721 no 340 0.0797625265003353 453 7175 A pharmaceutical preservative.
SGTC_2952 9073731 13.78 µM 1.40343762161955 0.083616986899477 no 341 0.0802431904424392 510 16457353
SGTC_3114 9122766 49.47 µM 1.39640660361048 0.0846913191331055 no 342 0.0812960438271305 457 17176985
SGTC_2463 5473429 200 µM 1.39601850466524 0.0847509203304377 no 343 0.0813544614172524 444 5399405
SGTC_1440 4100-1550 40 µM 1.39535575975864 0.0848527722119361 no 344 0.0814542925772019 415 742806
SGTC_849 0386-0493 241 µM 1.39224857306765 0.0853315144950138 no 345 0.0819235692903956 456 726119
SGTC_3296 9122258 64.045 µM 1.391539813401 0.0854410000838475 no 346 0.0820308976866076 495 4730474
SGTC_2992 9074591 71.4286 µM 1.38190516449937 0.0869397641396455 no 347 0.083500411001026 468 17741321
SGTC_3061 glucosamine 200 µM 1.37273025021469 0.0883851863200108 no 348 0.0849181107046772 459 91431 and experimental redox chemotherapeutic
SGTC_1221 2958-7315 257 µM 1.37098906766078 0.088661503482325 no 349 0.0851891820102194 498 4562705
SGTC_508 roscovitine 141 µM 1.36460525248617 0.08968008826558 no 350 0.0861885765120038 486 160355 A CDKinase inhibitor.
SGTC_170 4197-0004 226 µM 1.3630228940862 0.0899339055350639 no 351 0.0864376477157957 450 218692
SGTC_2114 5491910 81.25 µM 1.36181648664847 0.0901277769931617 no 352 0.0866279036094687 504 2849228
SGTC_2427 5545055 42.75 µM 1.35961287034208 0.0904827026221967 no 353 0.0869762315822298 547 5372858
SGTC_2715 st079500 56.4 µM 1.35462952236263 0.0912891710358042 no 354 0.0877678113036423 461 28246688
SGTC_1375 2910-0797 186 µM 1.35409278103717 0.0913763502169767 no 355 0.0878533895130372 501 742508
SGTC_2629 bisabolol 100 µM 1.35123701919302 0.0918412297864775 no 356 0.0883097598009153 539 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.35110300268599 0.0918630888240112 no 357 0.0883312198762427 500 6312947
SGTC_2194 5927483 104.545 µM 1.34967133966471 0.0920968436665278 no 358 0.0885607147701731 544 760979
SGTC_2917 7979103 53.79 µM 1.34360109870143 0.0930928556622051 no 359 0.0895387070175028 585 2980565
SGTC_3076 9116187 49.47 µM 1.33618744934975 0.0943200669857226 no 360 0.0907440061315103 471 27241210
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.3335704305001 0.0947561096498839 no 361 0.0911723395481165 544 5282309
SGTC_1035 k081-0041 55.2 µM 1.33354386784885 0.0947605430708266 no 362 0.0911766947905309 551 731709
SGTC_1444 4112-3581 28 µM 1.33346145153824 0.0947742996811169 no 363 0.0911902088442068 515 2877249
SGTC_150 3970-0969 77.2 µM 1.33339208964739 0.094785878438838 no 364 0.0912015834758828 611 6615640
SGTC_1790 st045711 43.5 µM 1.32136898975341 0.0968087095856259 no 365 0.0931891803298858 523 585119
SGTC_1518 st038567 90.8 µM 1.32002584441027 0.0970366413382023 no 366 0.0934131946776669 480 77966
SGTC_411 enrofloxacin 100 µM 1.31970407590331 0.0970913038917195 no 367 0.093466919335733 507 71188 A bacterial gyrase inhibitor.
SGTC_1691 st019933 84.6 µM 1.31939698599238 0.09714349389572 no 368 0.093518214436297 506 6176082
SGTC_1461 k072-0203 53.8 µM 1.31768299914899 0.0974351645497332 no 369 0.0938048940100691 504 5418714
SGTC_420 mitomycin C 81.9 mM 1.31246843340364 0.0983264810242382 no 370 0.0946810650448947 558 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1793 st048256 72.231 µM 1.30906078027759 0.0989121624545507 no 371 0.0952568815183633 500 672022
SGTC_931 2812-0076 566 µM 1.30894128339937 0.0989327468884182 no 372 0.095277120486543 568 3450959
SGTC_3130 9127414 49.47 µM 1.30681725194675 0.099299153883727 no 373 0.0956373922702708 512 1494646
SGTC_910 3454-3003 490 µM 1.30492799863766 0.0996258932299321 no 374 0.0959586831468487 579 820824
SGTC_1730 st033808 45.1 µM 1.30379026834064 0.0998230380821085 no 375 0.0961525507987021 611 1045166
SGTC_2900 5328528 85.29 µM 1.3009964159433 0.100308363014116 no 376 0.096629840761368 591 795359
SGTC_1785 bathophenanthroline 24 µM 1.30034303799357 0.100422110477466 no 377 0.0967417117546141 565 72812 An iron chelator.
SGTC_1317 1273-0028 910 nM 1.29962324761197 0.100547528698098 no 378 0.0968650639238518 544 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1021 4476-0760 85.3 µM 1.29787119161919 0.100853289189248 no 379 0.0971658004685634 549 746768
SGTC_1769 st044406 64.4 µM 1.29520474781123 0.101319924452668 no 380 0.0976248037098081 596 670903
SGTC_2605 digitonin 300 nM 1.28950416164981 0.102322815425436 no 381 0.0986114352331468 640 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3245 9134821 49.47 µM 1.2871886108809 0.102732240150151 no 382 0.099014277972179 565 17014901
SGTC_60 0986-0278 202 µM 1.286360524741 0.102878947059944 no 383 0.0991586342324733 421 3110598
SGTC_2278 7948257 134.34 µM 1.2852765230242 0.103071222923738 no 384 0.0993478355511533 556 1247028
SGTC_1250 0485-0349 40.2 µM 1.28498935545876 0.103122203254257 no 385 0.0993980018784373 535 6842794 YDL195W SEC31
SGTC_141 0443-0274 32.331 µM 1.28344961498356 0.103395862906317 no 386 0.0996673004906308 683 1627241
SGTC_1163 k060-0048 49.9 µM 1.28298447827285 0.103478635717341 no 387 0.0997487570481986 592 6809982
SGTC_2975 9084847 53.72 µM 1.28290188968664 0.103493337690462 no 388 0.0997632253670155 568 27211724
SGTC_2502 avocadyne acetate 18.59 µM 1.27947474171508 0.104104757392281 no 389 0.100364964326814 623 3952079
SGTC_269 exalamide 29 µM 1.27847361935897 0.104283855690759 no 390 0.100541240339732 543 3316 A derivative of salicylamide.
SGTC_3234 9132280 49.47 µM 1.26562110783317 0.106603000523185 no 391 0.102824382683678 595 17612295
SGTC_501 nsc-95397 161 µM 1.2626108362741 0.107151522933563 no 392 0.103364535811722 556 262093
SGTC_576 1073-0113 22.7 µM 1.26012548204242 0.107605928111851 no 393 0.10381204956856 747 5439563
SGTC_2173 5763948 167 µM 1.25416564915371 0.108701236365337 no 394 0.104890901318584 598 2867177
SGTC_2327 6189656 200 µM 1.25264499387826 0.108981984421735 no 395 0.10516746626889 551 5349088
SGTC_2523 spermine 47.74 µM 1.25225155153116 0.109054707755663 no 396 0.105239108353601 561 1103 A DNA binding polyamine.
SGTC_3047 9092122 49.47 µM 1.2502685118747 0.109421780964492 no 397 0.105600738448661 559 17173831
SGTC_130 0136-0219 337.655 µM 1.24664630423189 0.110094563821917 no 398 0.106263607716075 609 234244
SGTC_2330 7979373 200 µM 1.24501665986188 0.110398217238133 no 399 0.106562813201372 581 1863007
SGTC_1963 st076565 50.3 µM 1.24139246263915 0.111075669485393 no 400 0.107230401097888 572 4914280
SGTC_2802 7925815 54.55 µM 1.24029586329322 0.111281236544993 no 401 0.107432990958043 602 1262923
SGTC_651 3253-0966 34.4 µM 1.23647094289019 0.112000382413139 no 402 0.108141780044469 613 781462
SGTC_1268 0828-0275 2.46 µM 1.23563988384746 0.112157073165403 no 403 0.108296226247009 603 745337
SGTC_295 k015-0027 31 µM 1.23397952045964 0.112470592936879 no 404 0.108605267815133 581 3887424
SGTC_371 0195-0006 7.36 µM 1.23301669521311 0.112652685915891 no 405 0.108784767710225 506 3928593
SGTC_2749 bexarotene 57.39 µM 1.23283023772912 0.112687973747579 no 406 0.108819553695221 580 82146 An retinoic acid receptor inhibitor.
SGTC_2263 7948595 193.29 µM 1.23158545551848 0.112923756065465 no 407 0.109051988383283 524 2971371
SGTC_3351 9150312 21.596 µM 1.23046340250161 0.113136593040987 no 408 0.109261811790409 608 4904905
SGTC_378 3970-0959 8.33 µM 1.2290605562956 0.113403094802636 no 409 0.109524551199748 603 6615653
SGTC_249 wiskostatin 11.211 µM 1.22783405302983 0.11363646289336 no 410 0.109754634779907 605 2775510 A n-wasp and actin depolymerizer.
SGTC_903 1134-0042 114 µM 1.22467251631979 0.114239589987246 no 411 0.110349316659549 589 701009
SGTC_2084 5306078 60.6385 µM 1.2203495314881 0.115067971373803 no 412 0.111166200270787 583 679340
SGTC_2212 7123476 200 µM 1.21949981807659 0.115231296664884 no 413 0.111327272437517 509 1085715
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.21934869158777 0.115260362274101 no 414 0.111355937552314 580 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2159 5658611 73.75 µM 1.21282069972171 0.116520845226867 no 415 0.112599189761076 585 793844
SGTC_2477 5967686 25.23 µM 1.20941863482218 0.117181607867788 no 416 0.113251026491649 603 776118
SGTC_2381 9035592 200 µM 1.20103069440952 0.118822075322381 no 417 0.114869647498736 543 4749657
SGTC_1935 st074532 41.6 µM 1.20024526638322 0.118976511531673 no 418 0.115022049918947 719 2829742
SGTC_305 1682-2595 20.8 µM 1.19473698966752 0.120063569620684 no 419 0.116094902787924 641 226033
SGTC_918 glabranin 770.725 nM 1.19365763772535 0.120277397277048 no 420 0.116305958885182 633 124049 Also referred to as licorice root.
SGTC_2773 thioridazine 9.09 µM 1.19360267596434 0.120288292785091 no 421 0.116316713368068 632 5452 An antipsychotic.
SGTC_1620 st003704 16.5 µM 1.19316951202078 0.120374186661251 no 422 0.11640149615724 640 2834414
SGTC_422 cantharidin 155 µM 1.19070193470934 0.120864316855192 no 423 0.116885309071848 624 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_139 0099-0334 718.624 µM 1.19040438315083 0.120923513709698 no 424 0.116943745564688 721 97690
SGTC_2712 st079126 47.7 µM 1.18713718583461 0.121574853460702 no 425 0.117586756331065 582 3152970
SGTC_3272 9137413 49.47 µM 1.1851816463136 0.121965882223242 no 426 0.117972817511578 596 17614870
SGTC_2910 7948405 25.97 µM 1.18321862942273 0.122359293735664 no 427 0.118361255813813 577 2971328
SGTC_1051 3253-3903 78 µM 1.18297461070634 0.122408260105169 no 428 0.118409604912991 655 5509239
SGTC_425 3825-7017 13.1 µM 1.18248471514787 0.122506607222696 no 429 0.118506713418362 684 3397440
SGTC_697 0508-1955 564 µM 1.17745175918001 0.123520190512843 no 430 0.119507620669249 696 6243113
SGTC_695 3505-6186 243 µM 1.17308946413913 0.124403449562327 no 431 0.120379965546502 657 1819379
SGTC_1666 st014829 29 µM 1.17263379211034 0.124495966235458 no 432 0.12047134609023 659 3858230
SGTC_2978 9011784 42.97 µM 1.17196943326515 0.124630939494696 no 433 0.120604664239452 755 2994934
SGTC_3285 9112818 20.8695 µM 1.17077306755847 0.124874254833487 no 434 0.120845003100471 690 17017947 YPR165W RHO1
SGTC_1562 morin hydrate 59.1 µM 1.17038908129692 0.124952419781907 no 435 0.120922213813554 608 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3126 9127922 49.47 µM 1.16555364655441 0.125939655678217 no 436 0.121897479163396 632 45595682
SGTC_104 0074-0074 590.992 µM 1.16371033622651 0.126317426864064 no 437 0.122270709593878 506 3943124
SGTC_1607 st000305 50.6 µM 1.16036125322625 0.127005812840384 no 438 0.122950877638777 654 5457690
SGTC_2755 lomerizine 42.69 µM 1.16032317623547 0.127013654342954 no 439 0.122958625947747 674 3949 A calcium channel blocker.
SGTC_1052 3253-3998 198 µM 1.15924540874924 0.127235747472534 no 440 0.123178083475684 690 5450317
SGTC_898 1000-0849 28.3 µM 1.15838279635996 0.127413698619632 no 441 0.123353928288747 677 6751807
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.15761401042019 0.127572439809632 no 442 0.123510794595465 599 2346 DNA damaging agent; causes G2/M arrest.
SGTC_37 0566-0070 1.56 µM 1.15680536703336 0.127739559209529 no 443 0.123675944298996 700 1626686
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.15668122113222 0.127765229460894 no 444 0.123701312372604 603 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2204 7233102 200 µM 1.15625257570295 0.127853890120005 no 445 0.123788930130912 578 2172480
SGTC_20 0481-0013 4.944 µM 1.15388725573579 0.128343899760389 no 446 0.12427319735684 639 182045
SGTC_1670 st016595 4.04 µM 1.1533197773775 0.128461654646477 no 447 0.124389577688379 665 597879
SGTC_595 3909-8003 73.7 µM 1.14927432631661 0.129303280983093 no 448 0.125221440528786 660 699517
SGTC_2241 6772625 37.8075 µM 1.14883535755145 0.129394834517234 no 449 0.125311938389783 631 2285411
SGTC_1998 st075797 76.8 µM 1.14647040902335 0.12988885296189 no 450 0.12580028211219 739 24208315
SGTC_1812 st052057 4.327 µM 1.14531888665671 0.130129868694273 no 451 0.126038542550763 687 3645418
SGTC_2937 9044753 11.33 µM 1.1444759355373 0.130306495985837 no 452 0.126213156128861 697 6465530 YGL099W LSG1
SGTC_247 mechlorethamine 29.705 µM 1.14421541115444 0.130361118351861 no 453 0.12626715668874 610 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.14359965056627 0.130490283615326 no 454 0.126394853333016 739 91467 include heat shock
SGTC_1349 flufenamic acid 69 µM 1.14265294153408 0.130689043008251 no 455 0.126591357651422 639 3371 A non-steroidal anti-inflammatory.
SGTC_856 0433-0016 11.3 µM 1.14162676245691 0.130904723231382 no 456 0.126804597441826 687 3911780
SGTC_2290 7904846 200 µM 1.14086187363312 0.13106564592002 no 457 0.126963703764105 662 2962154
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.13988950326033 0.13127041726572 no 458 0.127166169344164 739 66535 A nucleotide analog.
SGTC_364 0083-0097 67.7 µM 1.13839884225011 0.131584764143462 no 459 0.127476988640559 676 5207356
SGTC_282 k297-0036 65.7 µM 1.13514723371636 0.132272256815774 no 460 0.128156816903618 625 5061378
SGTC_1755 st041960 45.185 µM 1.13489010050182 0.132326728340473 no 461 0.128210684120694 662 2257073
SGTC_2025 5147754 141 µM 1.1340550039355 0.132503743214369 no 462 0.128385738183357 656 315777 YLR208W SEC13
SGTC_71 0417-1750 47.813 µM 1.13238022684801 0.132859236159708 no 463 0.128737307105254 711 6811472
SGTC_2513 baicalein 25.65 µM 1.1294764168492 0.133477162431377 no 464 0.129348456279232 671 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_357 1325-0123 420 µM 1.12695994744538 0.134014259635067 no 465 0.129879707795001 652 1098503
SGTC_1989 st071868 50.2 µM 1.12687835805547 0.134031698308663 no 466 0.129896957366567 684 16414057
SGTC_2883 9059145 45.46 µM 1.12396690535154 0.134655004208527 no 467 0.130513532975644 639 16476510
SGTC_246 cycloheximide 667 µM 1.12120706608154 0.13524768550602 no 468 0.131099866335106 599 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1907 st060210 83.7 µM 1.12034767003182 0.135432607218952 no 469 0.131282817707897 761 688793
SGTC_148 3253-0744 288.01 µM 1.11936235000487 0.135644837923757 no 470 0.13149279310017 661 6893655
SGTC_3187 9109394 49.47 µM 1.1187411943936 0.135778747310012 no 471 0.13162528276866 694 17098090
SGTC_2234 tolnaftate 200 µM 1.11214258656079 0.13720687203678 no 472 0.133038424348445 636 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1806 st050005 60.3 µM 1.10903225454295 0.137883581022039 no 473 0.133708133897257 672 5194765
SGTC_613 3914-0030 117 µM 1.10557229543019 0.138639028764738 no 474 0.134455843347006 448 1145395
SGTC_2966 9084041 48.03 µM 1.10434015330315 0.138908734361643 no 475 0.134722805487431 650 17741380
SGTC_984 1492-0255 2.91 µM 1.10335486374028 0.139124662900529 no 476 0.13493654485945 674 1585198
SGTC_2695 st077686 51.995 µM 1.10230515697681 0.139354959845184 no 477 0.135164514073127 661 2876092
SGTC_1395 3486-0190 4.35 µM 1.10071802332418 0.139703656062744 no 478 0.13550969977265 745 6748079
SGTC_330 1488-0319 80.1 µM 1.10039878626615 0.139773864636526 no 479 0.135579203544474 700 6846614
SGTC_2642 cholecalciferol 100 µM 1.09915906619877 0.14004673889452 no 480 0.135849344942393 696 9821465 A vitamin D precursor, similar to steriods.
SGTC_2508 celastrol 40.54 µM 1.09866020689646 0.140156644667042 no 481 0.135958152889062 638 122724 Celastrol is a natural product and antioxidant.
SGTC_2292 7671323 168.05 µM 1.09797991094752 0.140306617913705 no 482 0.136106630758145 702 937504
SGTC_863 0466-0191 129 µM 1.0972127163123 0.140475878943291 no 483 0.136274207795298 758 765160 YPR165W RHO1
SGTC_15 0266-0086 27.098 µM 1.09660457450742 0.140610147666902 no 484 0.136407143457483 810 1712902 YIL048W NEO1
SGTC_2193 5925765 200 µM 1.09268424079232 0.141477789795681 no 485 0.137266230687115 648 877370
SGTC_1768 st044301 37.178 µM 1.09108225710868 0.141833380294125 no 486 0.137618344661925 737 3931349
SGTC_3334 9142812 21.919 µM 1.08881531481589 0.142337604294688 no 487 0.138117668332499 700 45283678
SGTC_1838 st055369 84.5 µM 1.08851925093731 0.142403545643174 no 488 0.138182971365222 671 676036
SGTC_2887 9044784 58.44 µM 1.08849658849588 0.142408594026651 no 489 0.138187970904244 780 6465546
SGTC_1993 st073995 70.8 µM 1.08745095109566 0.142641656401216 no 490 0.138418782077421 729 3098394
SGTC_417 st075190 100 µM 1.08512034227733 0.14316205397125 no 491 0.138934179378828 745 222757
SGTC_3112 9123419 49.47 µM 1.08261206602975 0.143723553753499 no 492 0.139490324673023 754 17015854
SGTC_375 3970-0961 9.27 µM 1.08138707838437 0.143998317437251 no 493 0.139762483543349 723 2898222
SGTC_703 3875-0075 71.8 µM 1.08034768615479 0.144231729873368 no 494 0.13999369108411 777 2850814
SGTC_1454 4239-0054 42.6 µM 1.0796373989032 0.144391383056525 no 495 0.140151840300084 781 1340767
SGTC_521 r062-0005 13.8 µM 1.07831572857497 0.144688775350887 no 496 0.140446440116836 699 2832033
SGTC_2391 6285546 200 µM 1.07755348526646 0.144860477044544 no 497 0.140616534889768 746 846083
SGTC_115 0527-0192 112.043 µM 1.07740987717031 0.144892841324515 no 498 0.140648596716213 812 4233931
SGTC_2987 9018338 71.43 µM 1.07417159450265 0.145623930510577 no 499 0.141372890514854 733 5055682
SGTC_664 1222-0054 14.9 µM 1.07413788461699 0.145631554026094 no 500 0.141380443541792 744 6813991
SGTC_1995 st072814 61.1 µM 1.07361969185739 0.145748777467396 no 501 0.141496584073537 704 5769371
SGTC_1789 tunicamycin 25 nM 1.07225870492165 0.146056956333814 no 502 0.141801924595824 732 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_210 3551-0445 56.827 µM 1.0697727213095 0.146621006339667 no 503 0.142360811903078 732 2865180 YOR207C RET1
SGTC_1093 fluphenazine 7.97 µM 1.06499682806799 0.147708715585695 no 504 0.14343868257327 756 6602611 An atypical antipsychotic.
SGTC_528 3492-0019 172 µM 1.06499101875181 0.147710041939056 no 505 0.143439997023242 907 2869262
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.06494170682054 0.147721300908211 no 506 0.143451154957696 725 2724278 An inhibitor of dopamine biosynthesis.
SGTC_578 3460-0051 92 µM 1.06125025994554 0.148565769212746 no 507 0.144288091936063 847 2876744
SGTC_2195 6536160 144.242 µM 1.0606592325578 0.148701273875282 no 508 0.144422396668337 658 3834386
SGTC_1994 st072947 40.9 µM 1.0588434052225 0.149118104703578 no 509 0.144835551133098 754 5286565 YDL195W SEC31
SGTC_3196 9111891 49.47 µM 1.05620644201622 0.149724819030714 no 510 0.145436954129208 716 18891510
SGTC_2785 7756463 72.73 µM 1.05573820604854 0.149832723018368 no 511 0.145543918422003 726 2201551
SGTC_1033 k072-0102 21.3 µM 1.05547500409846 0.149893400117455 no 512 0.145604067759208 769 5965931
SGTC_620 0109-0052 432 µM 1.05535694025659 0.149920623215759 no 513 0.145631054226817 776 493037
SGTC_839 0122-0028 230 µM 1.05460411741488 0.150094286246255 no 514 0.145803209951193 792 759448
SGTC_1384 3089-0840 101 µM 1.05404953958153 0.150222303380621 no 515 0.145930118419074 707 1069836
SGTC_2197 6588183 93.1375 µM 1.05257168994769 0.150563801150482 no 516 0.146268668899589 713 884136
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.05120104429058 0.150880988315 no 517 0.146583131829987 811 16486 A toxic proline analog.
SGTC_3115 9123671 49.47 µM 1.04969969769857 0.151228931638129 no 518 0.14692810139574 789 3286988
SGTC_1201 1889-3372 45.9 µM 1.04925847262633 0.151331288785942 no 519 0.147029586639442 730 5392199
SGTC_2703 st077852 53.4 µM 1.04780713766435 0.151668300219637 no 520 0.14736373665118 713 6281836
SGTC_1865 st057639 52.2 µM 1.0456398936664 0.152172479305142 no 521 0.147863661616949 753 688818
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.04485896281003 0.152354424413437 no 522 0.148044079349634 910 688664
SGTC_2902 5787006 60.46 µM 1.0410970374527 0.153232918778133 no 523 0.148915257187475 746 591003
SGTC_2968 9090663 33.37 µM 1.04042346313993 0.153390567165326 no 524 0.1490716027727 754 25236811
SGTC_969 1313-0238 134 µM 1.04032535908884 0.153413537134369 no 525 0.149094383176193 795 5212874
SGTC_1910 st062352 60.4 µM 1.03915318024418 0.153688165981011 no 526 0.149366750647867 738 2245730
SGTC_2951 9072950 58.06 µM 1.03851306192316 0.153838276110915 no 527 0.149515628677443 826 16488155
SGTC_190 3970-0790 3.722 µM 1.03786124008966 0.153991230442347 no 528 0.14966733043181 739 2832352
SGTC_2054 5233173 129 µM 1.03532797389119 0.154586633381332 no 529 0.150257884995418 806 6889
SGTC_2897 9048598 12.99 µM 1.0324126989108 0.15527370173044 no 530 0.150939412754187 722 6467404
SGTC_337 1315-0038 354 µM 1.03239270058091 0.155278421861563 no 531 0.150944095021981 774 1626437
SGTC_795 0685-0265 78 µM 1.03188153146098 0.155399103347219 no 532 0.151063809367213 798 302754
SGTC_3173 9105693 49.47 µM 1.02799701787729 0.156318216617943 no 533 0.15197561523353 802 17096658
SGTC_2828 7998861 71.43 µM 1.02773562502781 0.156380192998966 no 534 0.15203710257511 699 2988188
SGTC_3015 9080845 49.47 µM 1.02756322396794 0.156421078235754 no 535 0.152077665452688 829 5296973
SGTC_3023 9089636 49.47 µM 1.02701599432083 0.156550901410358 no 536 0.15220646638363 819 17249241
SGTC_1072 oxiconazole 14.9 nM 1.0227379887836 0.15756824739584 no 537 0.153215872330414 806 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1026 k007-1105 30.6 µM 1.02272317948157 0.157571776701611 no 538 0.153219374308729 827 7066794
SGTC_2189 6047310 154.431 µM 1.02128629896244 0.15791445650969 no 539 0.153559407884058 749 711535
SGTC_981 1488-1094 54.9 µM 1.02103567432659 0.157974277743787 no 540 0.153618768616138 724 3449522
SGTC_3121 9125696 49.47 µM 1.0206487145711 0.158066669828244 no 541 0.153710450313862 784 1235365
SGTC_1378 2093-0007 380 nM 1.01516431757359 0.159379960010112 no 542 0.155013753332092 770 3618014
SGTC_2444 5485484 36.41 µM 1.0145565014118 0.159525945783674 no 543 0.155158641633818 824 6790631
SGTC_2681 menadione 3.18 µM 1.01408134685504 0.15964012972274 no 544 0.155271968941601 775 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2459 5811157 9.22 µM 1.01031542083517 0.160547007143393 no 545 0.156172097649588 801 2870684 YBR192W RIM2
SGTC_2729 fluphenazine 10.66 µM 1.00908152917181 0.160844872691929 no 546 0.156467767768695 815 3372 An atypical antipsychotic.
SGTC_2109 5483026 200 µM 1.00896770229743 0.160872369042966 no 547 0.156495061983764 798 759335
SGTC_1796 st049173 110.4 µM 1.00822923911731 0.161050828883901 no 548 0.156672212061956 750 94134
SGTC_1752 st044819 83.042 µM 1.00778215401645 0.161158935944157 no 549 0.156779527517904 752 441209 YML126C ERG13
SGTC_797 k781-0471 270 µM 1.00318875401579 0.162272380834964 no 550 0.157884899007433 811 23738129
SGTC_711 k292-0785 179 µM 1.00237732253537 0.162469591918738 no 551 0.158080695242941 799 4146315
SGTC_1761 st044296 37 µM 1.00091386059079 0.162825667261465 no 552 0.158434227462037 779 1826700
SGTC_3218 9131285 49.47 µM 1.00016649372771 0.163007704917454 no 553 0.158614970677268 878 17156417
SGTC_568 1193-0097 7.48 µM 0.999627187999656 0.163139146850273 no 554 0.158745480336898 804 3646150
SGTC_2845 9003024 42.97 µM 0.996790600764459 0.163831625789199 no 555 0.159433080766297 809 2990173
SGTC_2842 9000675 19.48 µM 0.99464103618426 0.164357654713717 no 556 0.159955440789276 746 2989072
SGTC_1352 1496-0991 99 µM 0.993927485810575 0.164532512410175 no 557 0.160129085949158 804 3000039
SGTC_2913 7966556 36.57 µM 0.993622143082355 0.164607374398556 no 558 0.160203429885994 795 2976516
SGTC_448 monastrol 171 µM 0.993619283570944 0.164608075579684 no 559 0.160204126217926 811 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1681 tripelennamine 100 µM 0.987460222466042 0.166122830802709 no 560 0.161708536953594 757 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_891 0929-0073 133 µM 0.986945689934632 0.16624978087473 no 561 0.161834631930833 823 5603632
SGTC_1863 st057641 20.1 µM 0.984711752230072 0.166801684350621 no 562 0.16238283918768 870 3921635
SGTC_3337 9144342 33.5465 µM 0.98464622456324 0.166817891054191 no 563 0.162398937872163 834 17682949
SGTC_1920 st075728 45.7 µM 0.98457294559769 0.166836016059588 no 564 0.162416942107976 811 3400306
SGTC_178 4092-0806 87.505 µM 0.981814140395319 0.167519310097629 no 565 0.16309571028567 863 2169044
SGTC_1669 st015249 58.4 µM 0.981739629616623 0.167537789711768 no 566 0.163114068228566 873 722793
SGTC_1623 st003709 20.3 µM 0.980340342964509 0.167885074360477 no 567 0.163459073462563 863 16192618
SGTC_3217 9129673 49.47 µM 0.978679038118161 0.168297989761919 no 568 0.163869296280224 776 17248312
SGTC_3315 9136395 68.55 µM 0.978408758826148 0.16836522909834 no 569 0.163936098961946 885 16876844
SGTC_3267 9137951 49.47 µM 0.978284634543578 0.168396114183082 no 570 0.16396678364724 811 16643986
SGTC_2390 9097792 176.6 µM 0.977396074041126 0.1686173156377 no 571 0.164186552939911 786 4497149
SGTC_408 cantharidin 100 µM 0.970768706636752 0.170273044341363 no 572 0.165831734540588 844 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2250 alverine citrate 130 µM 0.969751814818565 0.170528015131555 no 573 0.16608510811907 879 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1794 st048918 76.9 µM 0.967955071692409 0.17097911951498 no 574 0.166533404192321 774 672303
SGTC_1100 amiodarone 5.07 µM 0.967199000477657 0.171169172668582 no 575 0.16672228088379 886 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_659 k018-0002 107 µM 0.967010473954215 0.171216583498711 no 576 0.166769398850412 852 6797879 YHR007C ERG11
SGTC_2424 5537928 59.2 µM 0.96409142117917 0.171951740999297 no 577 0.167500046679062 862 5382802
SGTC_2203 7227154 166.4 µM 0.963234028590054 0.172168055924838 no 578 0.167715045910116 834 896304
SGTC_679 0422-0091 41.4 µM 0.962876861351762 0.172258218260316 no 579 0.167804661356523 870 627384 YHR062C RPP1
SGTC_2223 6903751 107.57 µM 0.961564066728951 0.172589875415182 no 580 0.16813431442525 786 5598863
SGTC_1957 st077035 62.4 µM 0.961272883772013 0.172663493397219 no 581 0.168207489182257 865 705593
SGTC_1472 k841-0093 193 µM 0.960855711922235 0.172768999251111 no 582 0.168312360853141 880 X1472
SGTC_2146 5545642 200 µM 0.960554527563224 0.172845196546153 no 583 0.168388100886932 843 825326
SGTC_823 0417-1665 178 µM 0.95980437824961 0.173035071557969 no 584 0.168576839195643 856 3429856
SGTC_258 haloperidol 50.781 µM 0.959097635206169 0.173214081253891 no 585 0.168754780812532 811 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_742 0kpi-0133 140 µM 0.957728390993167 0.173561230135454 no 586 0.169099868277259 877 2728852
SGTC_1613 st002381 52.1 µM 0.955711632989174 0.174073350966461 no 587 0.169608971817263 878 551167
SGTC_3326 9140064 16.379 µM 0.952392324737783 0.174918321110666 no 588 0.170449025265424 826 1868434
SGTC_2873 9040596 71.43 µM 0.950350890958834 0.17543928324267 no 589 0.170966994141155 832 6463863
SGTC_3054 9094397 49.47 µM 0.950066182762665 0.175512017205614 no 590 0.171039312506835 871 2598354
SGTC_149 3970-0822 46.1 µM 0.94808252886364 0.176019308542191 no 591 0.171543720883259 963 3114250 YBL034C STU1
SGTC_136 0097-0015 404.482 µM 0.94555013103298 0.176668280976653 no 592 0.172189045033995 942 4861337
SGTC_2525 harmine 47.85 µM 0.942586933191783 0.177429571860678 no 593 0.172946113010217 825 5280953 A monoamine oxidase inhibitor
SGTC_880 0833-0487 87.2 µM 0.93944704471498 0.178238513564607 no 594 0.173750634352207 843 76075
SGTC_56 0957-0365 83.25 µM 0.937995190516115 0.178613345041967 no 595 0.174123440869389 856 6752360
SGTC_879 0831-1030 162 µM 0.93740566114793 0.178765687990562 no 596 0.174274965010313 881 1549252
SGTC_979 1426-2828 121 µM 0.936825381289866 0.178915720591543 no 597 0.174424193589077 919 747872
SGTC_68 0986-0284 82.829 µM 0.930561136722038 0.180540396508123 no 598 0.176040312769304 715 423278 YIL048W NEO1
SGTC_2475 5812728 15.03 µM 0.930510499252515 0.180553567281227 no 599 0.176053415292463 957 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_709 3807-1509 243 µM 0.929343724232087 0.180857211610256 no 600 0.176355491120386 874 1886677 YPL242C IQG1
SGTC_367 0335-0881 7.1 µM 0.926711220768263 0.181543475521966 no 601 0.177038245033453 883 23828853
SGTC_1642 st009582 77.7 µM 0.925940186080701 0.18174478373963 no 602 0.177238532801325 857 6739311
SGTC_391 gliotoxin 8.33 µM 0.924215905691949 0.182195478485828 no 603 0.177686957974636 936 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.923152826298066 0.182473695418056 no 604 0.177963784243153 871 140250 A respiratory chain inhibitor.
SGTC_2882 9058044 58.44 µM 0.923101622132453 0.182487102679949 no 605 0.177977124688431 863 18076804
SGTC_1981 st071826 47 µM 0.921533840639307 0.18289790727033 no 606 0.178385890862095 829 11838600
SGTC_639 0833-0042 114 µM 0.919030315377277 0.183555099673226 no 607 0.179039857931548 916 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3164 9100705 49.47 µM 0.91716368842812 0.184046058417216 no 608 0.179528435721911 874 17174235
SGTC_2108 5365811 200 µM 0.916392508508183 0.184249131983069 no 609 0.17973053157952 928 780283
SGTC_3278 9139605 49.47 µM 0.915044167432071 0.184604523342814 no 610 0.180084221889827 867 7958859
SGTC_270 tamoxifen 5.46 µM 0.913680210801862 0.184964463988779 no 611 0.180442452660486 958 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_390 dec-rvkr-cmk 16.7 µM 0.913640593325381 0.184974925335663 no 612 0.18045286450598 930 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_382 3229-0966 23.2 µM 0.912752684789024 0.185209481923126 no 613 0.180686314092125 928 5722370
SGTC_1583 clindamycin 39.6 µM 0.912499975762363 0.185276273190106 no 614 0.180752791143208 789 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1153 4055-0057 267 µM 0.912143980843966 0.185370388400771 no 615 0.180846464352325 906 882706
SGTC_700 3453-2283 142 µM 0.911273606312272 0.185600616317313 no 616 0.181075614765615 944 565664
SGTC_1347 1493-0251 600 nM 0.911006304157677 0.185671357589561 no 617 0.181146026021913 965 3986378
SGTC_680 0417-1641 114 µM 0.910254007464142 0.185870542001998 no 618 0.181344283901978 838 2835990
SGTC_272 doxorubicin 8.13 µM 0.910160073553408 0.185895422038717 no 619 0.181369048484199 945 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2651 TUB2.036 5 µM 0.908007761893149 0.186466065051489 no 620 0.181937060391976 1050 15992207 YFL037W TUB2
SGTC_860 0443-0016 25.1 µM 0.906164648619604 0.18695559157712 no 621 0.182424355624872 968 5337942
SGTC_766 1391-0721 126 µM 0.904886670915775 0.187295485800292 no 622 0.182762714564285 927 1020919 YIL115C NUP159
SGTC_1686 st019653 115.5 µM 0.903410966650601 0.187688442845385 no 623 0.183153910883719 929 97252
SGTC_3120 9124077 49.47 µM 0.903393882028247 0.187692995194278 no 624 0.183158442924212 932 18774327 YGL155W CDC43
SGTC_3036 9090181 49.47 µM 0.901595685307296 0.188172521974462 no 625 0.183635841936308 893 25236586
SGTC_1292 0kpi-0043 232 µM 0.89984936789132 0.188638936971048 no 626 0.184100209045879 881 3333905
SGTC_72 0744-0168 198.391 µM 0.899149152222503 0.188826154002197 no 627 0.184286610068682 869 677577
SGTC_3295 9122362 53.5725 µM 0.897758793647088 0.189198234150309 no 628 0.184657078650343 861 4730473
SGTC_3158 9100007 49.47 µM 0.897669652177317 0.189222105092263 no 629 0.184680846663922 872 19297233
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.897605547212312 0.18923927272567 no 630 0.184697940307173 924 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1773 st048542 73.5835 µM 0.893316073008057 0.190390193662392 no 631 0.185843966468 881 3237138
SGTC_1934 st074720 32.6 µM 0.89301912571039 0.190470027213222 no 632 0.1859234652706 971 17250992
SGTC_2037 5169046 200 µM 0.892353485050882 0.190649057735531 no 633 0.186101747351087 914 5718022
SGTC_2352 9027995 87.8 µM 0.8912314787806 0.190951065917958 no 634 0.186402500015851 870 2997347
SGTC_2618 avocadyne 43.43 µM 0.890887672994359 0.191043666139457 no 635 0.186494717044401 917 3015189
SGTC_49 0717-0965 32.132 µM 0.888091741908526 0.191797740953076 no 636 0.187245702199399 978 5889349 YGL099W LSG1
SGTC_665 3914-0008 307 µM 0.887323574543525 0.192005237740703 no 637 0.187452358421719 892 1069549
SGTC_97 0535-0701 19.132 µM 0.886970983514718 0.192100525346169 no 638 0.187547261405365 856 2832013 YGL099W LSG1
SGTC_3005 9076496 71.4286 µM 0.885952715834728 0.192375874240498 no 639 0.187821503771013 915 21368410
SGTC_2706 st078239 82.5 µM 0.883883810087812 0.192936068119279 no 640 0.188379468853289 948 15434492
SGTC_3086 9117350 49.47 µM 0.883782861320938 0.19296342730298 no 641 0.188406719954004 897 2679265
SGTC_1805 st050013 60.3 µM 0.88354036083093 0.193029159584737 no 642 0.188472192851337 904 4037144
SGTC_579 4491-1009 110 µM 0.882408774007852 0.193336068691434 no 643 0.188777896329502 1130 1271041
SGTC_2120 5538279 151.968 µM 0.882190451672749 0.193395316348563 no 644 0.188836912278836 930 2058197
SGTC_470 aa-861 153 µM 0.880642266098026 0.193815776012651 no 645 0.189255737195639 921 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2866 9034245 58.44 µM 0.879037097433152 0.19425229912773 no 646 0.189690580882922 947 6462273
SGTC_2465 5809242 33.21 µM 0.878856837011274 0.194301358034693 no 647 0.189739452176192 951 2731748
SGTC_548 1436-0017 110 µM 0.878012679827296 0.194531200625693 no 648 0.189968418826662 1006 9677137
SGTC_1825 st052143 62.6 µM 0.877692788741788 0.194618342070634 no 649 0.190055229478776 914 674173
SGTC_2183 6420625 130.508 µM 0.877153603173476 0.194765275215293 no 650 0.190201606484702 968 2897619
SGTC_2320 7373003 200 µM 0.875475708718825 0.195222948804656 no 651 0.190657560853926 955 5415828
SGTC_133 0724-0033 378.92 µM 0.873072880053098 0.195879497200775 no 652 0.191311677420701 900 280309
SGTC_872 0588-0139 234 µM 0.871763922635002 0.196237719508422 no 653 0.191668589955614 988 2047100
SGTC_2867 9039098 71.43 µM 0.871752220824393 0.196240923732606 no 654 0.19167178251842 891 6463460
SGTC_359 0081-0058 15.9 µM 0.871452879481359 0.196322901043591 no 655 0.191753461810018 862 3494159
SGTC_2789 5281112 71.43 µM 0.871297840652361 0.196365367976317 no 656 0.191795774606292 915 765948
SGTC_1539 benzyladenosine 56 µM 0.869885853825675 0.196752383755541 no 657 0.192181393458805 946 92208 A nucleotide analog.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.86956569499553 0.196840201271106 no 658 0.192268895946283 1048 6708784 An antioxidant flavonoid
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.869536647221065 0.196848170063677 no 659 0.192276836187994 1012 5106787 A p450 inhibitor.
SGTC_2412 st077135 33.4 µM 0.869389885245915 0.196888434851993 no 660 0.192316956804868 929 13258915
SGTC_1862 st057513 3.81 µM 0.865514292917973 0.197953524137958 no 661 0.193378287250412 971 5393163
SGTC_1032 k061-1018 98.7 µM 0.864839882891845 0.198139220176693 no 662 0.193563338727079 1021 4005393
SGTC_1063 disulfiram 1.84 µM 0.861801948398588 0.198977006094865 no 663 0.194398256285571 956 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3030 9087619 49.47 µM 0.861787007198729 0.198981131770211 no 664 0.194402367995957 985 25236973
SGTC_2396 5342950 42.78 µM 0.860826736371559 0.199246397011839 no 665 0.194666738633725 946 1886677
SGTC_526 4469-0568 170 µM 0.85847752258167 0.19989624111919 no 666 0.195314418479169 928 2901964
SGTC_176 1486-1328 72.834 µM 0.857612438032832 0.200135863239128 no 667 0.195553252326551 993 22310231
SGTC_1016 4226-1401 38 µM 0.856640513537203 0.200405285094825 no 668 0.19582179415317 975 2901613
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.856477418101079 0.20045051722343 no 669 0.195866879187693 945 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2004 4023728 41.89 µM 0.855017548340648 0.200855663724906 no 670 0.19627071648647 981 360084 YDR527W RBA50
SGTC_1257 0669-0121 16 µM 0.854973076080973 0.200868013479088 no 671 0.196283026568348 1059 4307855
SGTC_1130 3454-2858 15.9 µM 0.853842174595181 0.201182213024491 no 672 0.196596221451285 904 715628 YIL048W NEO1
SGTC_1506 4226-2149 212 µM 0.853484054429384 0.201281771331201 no 673 0.196695463291084 1012 991114
SGTC_503 tyrphostin 8 294 µM 0.852680610134608 0.201505238304227 no 674 0.196918223206988 958 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1996 st072960 66.8 µM 0.85025891119993 0.202179699297449 no 675 0.197590577642241 996 1719405
SGTC_385 1494-0393 12.4 µM 0.849313633644201 0.202443332126152 no 676 0.197853398249085 983 3090647
SGTC_2115 tiliquinol 12.7705 µM 0.849297373097746 0.202447868902711 no 677 0.197857921103303 950 71208 A bioactive hydroxyquinoline.
SGTC_2601 securinine 100 µM 0.847443918771615 0.202965390528438 no 678 0.198373866753349 928 442872 A GABA receptor antagonist.
SGTC_1770 st043884 66.3 µM 0.845338020173658 0.203554357480449 no 679 0.198961069479667 1016 670149
SGTC_2771 fluoxetine 41.05 µM 0.844312726815557 0.203841474849025 no 680 0.199247338085716 946 3386 A selective serotonin reuptake inhibitor.
SGTC_2279 7948423 32.93 µM 0.843696602056867 0.204014126999962 no 681 0.199419483404855 966 1247112
SGTC_2643 anethole 100 µM 0.84317778651658 0.204159578447209 no 682 0.199564509938958 1018 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1945 st075991 56.6 µM 0.841441000591885 0.204646940686591 no 683 0.200050462198372 886 1084980
SGTC_1405 3909-7894 12 µM 0.837302118094489 0.205811145570211 no 684 0.201211384494211 1008 7104060
SGTC_3174 9107204 49.47 µM 0.835453869425227 0.206332296581411 no 685 0.201731104987544 966 3938802
SGTC_1382 3002-2117 298 µM 0.834903012625495 0.206487772922244 no 686 0.201886159202951 1058 1497314
SGTC_1233 0325-0408 14.2 µM 0.834579449035953 0.206579129336197 no 687 0.201977268574158 988 12874
SGTC_35 0133-0054 64.071 µM 0.834210239093933 0.206683402987195 no 688 0.202081261150783 948 99677
SGTC_323 4013-0906 34.3 µM 0.830525903611022 0.207725652977191 no 689 0.203120754228508 1031 2910086
SGTC_1846 st056244 14.8 µM 0.829852243323914 0.207916557787575 no 690 0.203311164386333 1000 5393182
SGTC_175 3793-3120 23.7 µM 0.829105669682819 0.208128246077682 no 691 0.203522307897609 969 5322297
SGTC_344 k064-0035 6.43 µM 0.827326608180885 0.208633205035644 no 692 0.204025983138528 961 5088750
SGTC_1303 1160-0052 261 µM 0.82570810534423 0.209093218666822 no 693 0.204484846641965 1052 3562476
SGTC_3250 9135583 49.47 µM 0.823716369861854 0.209660132065355 no 694 0.205050367916645 995 7699353
SGTC_632 0781-2353 4.65 µM 0.822632047276698 0.209969145546397 no 695 0.205358634299225 1024 6811515 YHR007C ERG11
SGTC_2325 6158266 200 µM 0.822461189389324 0.210017861533566 no 696 0.205407233259624 982 3623240
SGTC_296 1222-0039 74.9 µM 0.822005447301007 0.210147837827845 no 697 0.205536898324639 980 5984176
SGTC_2728 chlorpromazine 9.18 µM 0.821649789636858 0.210249303157856 no 698 0.205638121708753 957 2726 A thorazine and dopamine antagonist.
SGTC_18 0111-0177 500 nM 0.820555129550556 0.210561778471747 no 699 0.205949857497013 1100 721752
SGTC_2594 a-mangostin 100 µM 0.819863343580159 0.210759392135946 no 700 0.206147007816499 1023 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1040 k898-0338 155 µM 0.819393697323793 0.210893611957928 no 701 0.206280914849192 1074 20969351
SGTC_2243 6634756 200 µM 0.818311364450496 0.211203121775306 no 702 0.206589709277653 965 885676
SGTC_1832 st054113 55 µM 0.817456866061479 0.211447666708811 no 703 0.206833694793192 1011 1251267
SGTC_749 1000-0129 128 µM 0.816366163338536 0.211760050647084 no 704 0.2071453715785 1073 708470
SGTC_338 4055-0136 114 µM 0.816096425770595 0.211837346770484 no 705 0.207222494013072 1032 2900563
SGTC_2408 sulbentine 18.36 µM 0.815279455257888 0.212071558912611 no 706 0.207456182984993 976 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1445 4239-0156 97.7 µM 0.815171689362136 0.21210246494037 no 707 0.207487020326501 1095 4008346
SGTC_2723 salbutamol 83.58 µM 0.814521589087426 0.212288962127432 no 708 0.207673104768126 956 9884233 β2-adrenoceptor agonist
SGTC_1075 aripiprazole 15.2 µM 0.813502976028094 0.212581368881674 no 709 0.207964870353301 1074 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1725 st036284 20.55 µM 0.812790923580163 0.212785912855621 no 710 0.208168970145193 1070 707914
SGTC_902 1120-0002 2.07 µM 0.812308655448706 0.212924514290901 no 711 0.208307272619861 1043 3280475
SGTC_2566 crystal violet carbinol 226 nM 0.811690080868586 0.213102366617301 no 712 0.208484743713201 941 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2350 9023895 38.85 µM 0.810654676180247 0.213400259622088 no 713 0.208782004186873 1006 2997209
SGTC_582 0987-0078 156 µM 0.809830256780691 0.213637624206031 no 714 0.209018870146582 1133 1625765
SGTC_3021 9087658 49.47 µM 0.808133865797343 0.214126528062165 no 715 0.209506761995409 1026 25237042
SGTC_2572 astragaloside iv 100 µM 0.806149187616635 0.214699342575315 no 716 0.210078416469119 1001 45006101 An anti-inflammatory agent.
SGTC_780 0109-0199 192 µM 0.805521888348673 0.214880577685446 no 717 0.210259290301953 1089 610414
SGTC_2268 7933382 153.85 µM 0.805118584539697 0.214997144443221 no 718 0.210375626152258 1126 935025 YOR257W CDC31
SGTC_2089 5281248 129.67 µM 0.799538693039226 0.216613663119673 no 719 0.211989059970477 1007 2737878
SGTC_3043 9092303 49.47 µM 0.798851503696503 0.216813229949201 no 720 0.21218826108086 1018 25236084
SGTC_2370 9071495 200 µM 0.798171371692925 0.217010851889059 no 721 0.212385524128247 967 21791103
SGTC_473 2-arachidonoylglycerol 10 µM 0.797356230437268 0.217247839760578 no 722 0.212622085892539 973 5282280 An endocannabinoid.
SGTC_2091 4-phenylthiadiazole 200 µM 0.797240826024618 0.217281403623334 no 723 0.212655589783703 1047 270010
SGTC_1237 0330-0133 46.1 µM 0.796129757035805 0.217604696671454 no 724 0.212978309954998 994 X1237 YHR072W ERG7
SGTC_2165 5727197 32.143 µM 0.794169059810476 0.218175886753459 no 725 0.213548509018007 1046 1361712
SGTC_3138 9097216 49.47 µM 0.793216066219751 0.218453824484011 no 726 0.213825974264856 1090 25237486
SGTC_2945 9067681 61.76 µM 0.79288477611089 0.218550491996349 no 727 0.213922478937964 1082 16456930
SGTC_479 n-linoleoylglycine 10 µM 0.791984641154936 0.218813267720107 no 728 0.21418481589517 1044 6433346 An anti-infammatory.
SGTC_2851 9015922 71.43 µM 0.790517578736398 0.219241935526127 no 729 0.214612780117513 1033 2996893
SGTC_2495 cafestol 54.53 µM 0.789679582316724 0.219487010062316 no 730 0.214857459179401 1038 16667697 An anti-infammatory.
SGTC_2922 7999257 32.47 µM 0.788961898557016 0.219697023852391 no 731 0.215067137986322 995 2988377
SGTC_2775 cyproheptadine 69.59 µM 0.788632544925535 0.219793440294498 no 732 0.215163401847766 1095 2913 A selective serotonin reuptake inhibitor.
SGTC_1802 st050112 57.9 µM 0.787892010145321 0.220010316410408 no 733 0.215379937530506 1095 4662563
SGTC_2678 equilin 100 µM 0.787814262608508 0.220033092999085 no 734 0.215402678589437 1085 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_622 1348-1566 26.3 µM 0.787454824228531 0.220138410124506 no 735 0.215507831978822 1109 7340407
SGTC_3141 9094609 49.47 µM 0.786958039483378 0.220284017960863 no 736 0.215653214930005 981 25236309 YDL196W YDL196W
SGTC_224 benfluorex 43.875 µM 0.785841694794153 0.220611420484395 no 737 0.215980118105625 1054 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1559 coumarin 343 70.1 µM 0.785822796297049 0.220616965450317 no 738 0.215985654689649 1026 108770 A hepatotoxic, DNA x-linker.
SGTC_74 000s-0487 160.283 µM 0.782437996951878 0.221611378872452 no 739 0.216978605324264 1087 677548
SGTC_167 3672-0051 66.205 µM 0.781617802538197 0.221852727137736 no 740 0.217219610651974 1048 3237971
SGTC_2611 pyromycin 23.93 µM 0.779562549931932 0.222458159356387 no 741 0.217824203303834 1062 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2980 9014342 25.29 µM 0.77949542502641 0.222477948754181 no 742 0.21784396575815 997 2996599
SGTC_197 4544-0043 41.561 µM 0.778651718845184 0.2227267711959 no 743 0.21809245211633 1106 896523
SGTC_3080 9117754 49.47 µM 0.77801660114206 0.22291418214719 no 744 0.218279613221108 1107 9550191
SGTC_2187 6125751 200 µM 0.776193941157721 0.223452512392232 no 745 0.218817241480506 1052 874498
SGTC_2977 9011197 71.43 µM 0.775402315598277 0.223686552487103 no 746 0.219050983631728 1000 2704722
SGTC_2664 lyso-paf C-16 73.48 µM 0.774748092167932 0.223880075479617 no 747 0.219244263571583 1096 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1056 3448-1962 115 µM 0.774370603395928 0.223991782070276 no 748 0.219355831228794 1027 715507
SGTC_3277 9138724 49.47 µM 0.774027692820228 0.224093283713497 no 749 0.219457207495266 968 15943418
SGTC_84 0443-0269 128.823 µM 0.773814785439818 0.224156317511988 no 750 0.219520163847288 1058 6150058
SGTC_2060 5238662 140 µM 0.773300182459023 0.224308713506921 no 751 0.219672373910892 1023 790130
SGTC_1242 0402-0103 60.1 µM 0.773184841863621 0.22434287886724 no 752 0.219706497841843 1043 432868
SGTC_106 0092-0003 11.579 µM 0.772844680439727 0.224443656234457 no 753 0.219807153547188 1040 1072148
SGTC_1173 0443-0020 122 µM 0.770986893539485 0.224994503528121 no 754 0.220357350129791 1074 5331295
SGTC_451 chloral hydrate 100 µM 0.770288092078005 0.225201901365688 no 755 0.220564509221187 1121 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1733 st037357 54.9 µM 0.768705518529505 0.225671994719232 no 756 0.22103407405797 1103 1272339 YGL099W LSG1
SGTC_3210 9128157 49.47 µM 0.768654131414282 0.225687268233885 no 757 0.221049330694559 977 17590849
SGTC_2630 antimycin a 100 µM 0.768495890588946 0.225734304972687 no 758 0.221096315571193 1142 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_90 0870-0863 4.608 µM 0.767499305157441 0.226030665219298 no 759 0.221392353079099 1085 1738164
SGTC_2898 9056270 58.44 µM 0.766962435238568 0.226190408374755 no 760 0.221551925151731 1023 19154699
SGTC_232 clozapine 119 µM 0.766554646232729 0.226311786719737 no 761 0.221673174848887 1052 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2772 vinpocetine 57.06 µM 0.765194499224229 0.226716900209074 no 762 0.222077867370036 1068 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1682 st012968 530 nM 0.76398438118613 0.227077672008556 no 763 0.222438275153195 1032 24207270
SGTC_1966 st070145 16.1 µM 0.760436842931135 0.228137160659521 no 764 0.223496753814628 1080 3748532
SGTC_460 trequinsin 123 µM 0.758867545525211 0.228606723851996 no 765 0.223965897450461 1140 5537 A vasodilator.
SGTC_1466 k213-0079 57.5 µM 0.758808751617884 0.228624326633443 no 766 0.223983484838061 1080 3657981
SGTC_57 miconazole 162.5 nM 0.758561039667922 0.228698499468353 no 767 0.224057593073028 1059 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1840 st055363 71 µM 0.758200271253399 0.228806549169158 no 768 0.224165549435757 1050 676033
SGTC_1355 1499-0035 1.68 µM 0.757483502324078 0.229021305589591 no 769 0.224380123037106 1093 1548538
SGTC_410 α-linolenic acid 100 µM 0.756426378923187 0.229338244407373 no 770 0.224696798597584 1116 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2010 4012422 159 µM 0.755879842128954 0.229502199345425 no 771 0.224860620410507 1073 952393
SGTC_2274 7947094 46.08 µM 0.755648032275659 0.229571759545775 no 772 0.224930124760414 1135 2971028
SGTC_122 0236-0016 402.397 µM 0.755558349558944 0.229598674200839 no 773 0.224957017906111 1194 6808838
SGTC_562 3772-2733 112 µM 0.754164002461618 0.230017358641554 no 774 0.225375374970339 1143 2876874 YIL048W NEO1
SGTC_2418 pentamidine 31.67 µM 0.753015461233757 0.230362554957393 no 775 0.225720311566084 1122 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_429 1112-0049 25.5 µM 0.751904958131229 0.230696594085663 no 776 0.226054108123569 1033 2836170
SGTC_2589 lobaric acid 100 µM 0.750762615300202 0.231040492762548 no 777 0.226397766049427 1122 73157 A novel microtubule depolymerizer.
SGTC_1723 st034307 2.5525 µM 0.748227186375096 0.2318047969467 no 778 0.227161567710207 1139 867466
SGTC_2792 7535235 81.82 µM 0.743677800176272 0.233179732261473 no 779 0.228535711509414 1073 1281891
SGTC_126 0417-1624 672.48 µM 0.740222040553634 0.234227165218468 no 780 0.229582637974858 1246 41912 YDL195W SEC31
SGTC_1622 st003707 19.4 µM 0.739409534354408 0.23447381167703 no 781 0.229829177246711 1128 10140899
SGTC_2875 9039966 71.43 µM 0.738755033292771 0.234672598141227 no 782 0.230027880665456 1162 6463691
SGTC_1741 st038134 10.228 µM 0.737512295478286 0.235050301466947 no 783 0.230405434408373 1180 1272587
SGTC_1822 st052468 42 µM 0.735427108167201 0.235684802912999 no 784 0.231039708727386 1131 2873678
SGTC_1433 4060-0023 7.6 µM 0.734412815572736 0.235993783076571 no 785 0.231348589226899 1146 3840627
SGTC_1396 3511-0007 98.6 µM 0.733608516332821 0.236238952346046 no 786 0.231593684502359 1085 X1396
SGTC_1184 1269-1718 139 µM 0.731286409812712 0.236947571316055 no 787 0.232302114857357 1155 5403821
SGTC_540 1187-0821 17.3 µM 0.729451157953828 0.237508446289962 no 788 0.232862867073193 1125 847520
SGTC_949 1165-0505 146 µM 0.729384900094414 0.237528709106522 no 789 0.232883125892634 1166 6244267
SGTC_1497 4476-2978 41.3 µM 0.728415418522605 0.23782530207231 no 790 0.233179663839783 1181 1528379
SGTC_1328 1441-0025 69.2 µM 0.72773157113888 0.238034633227773 no 791 0.233388960091414 1116 4562601
SGTC_1826 st055655 41.6 µM 0.726533476463948 0.238401622933609 no 792 0.233755896437119 1119 676168
SGTC_127 0180-0333 59.125 µM 0.72561690920967 0.238682586710739 no 793 0.234036826093169 1143 771601
SGTC_392 N-ethylmaleimide 8.33 µM 0.72534523477699 0.238765900367377 no 794 0.234120130752599 1111 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1116 jasmonic acid 1.58368 µM 0.724859799920172 0.238914806952363 no 795 0.234269022532553 1172 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2161 5662504 8.5105 µM 0.722579810656245 0.239614869970532 no 796 0.234969037837137 1111 2859334
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.721556102240309 0.239929560041237 no 797 0.235283718197306 1246 688801
SGTC_3192 9110362 49.47 µM 0.721504702423555 0.239945366391033 no 798 0.235299524251024 1185 16649480
SGTC_2797 7859098 81.82 µM 0.721428731861585 0.239968729718082 no 799 0.235322887173999 1188 972681
SGTC_1985 st071382 65.5 µM 0.71999762904447 0.240409070360699 no 800 0.235763227681523 1206 6123237
SGTC_2302 7771753 200 µM 0.719277615966921 0.240630779814622 no 801 0.235984942438588 1167 2203047
SGTC_2570 licareol 100 µM 0.719100347911125 0.240685382009422 no 802 0.236039546490825 1110 443158
SGTC_14 0354-0009 295 µM 0.718925808109711 0.240739150434036 no 803 0.236093316957344 1193 1713507
SGTC_3233 9132340 49.47 µM 0.718745245603305 0.240794781080941 no 804 0.236148949939103 1135 17682950
SGTC_3297 9117502 71.43 µM 0.718560780826005 0.240851621225725 no 805 0.236205792702873 1164 7453720
SGTC_1594 piperine 70.1 µM 0.716104711811621 0.241609118428111 no 806 0.236963347291897 1151 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3227 9130768 49.47 µM 0.715744879237639 0.241720205996897 no 807 0.237074446787737 1165 17720899
SGTC_2445 5742597 35.57 µM 0.714081195621001 0.242234178878664 no 808 0.237588486515553 1120 1774255
SGTC_2168 5727979 200 µM 0.713639768731745 0.242370651204322 no 809 0.23772497980869 1115 695210
SGTC_254 nsc-64875 3.808 µM 0.712727407265278 0.242652850491132 no 810 0.238007226728792 1189 56993
SGTC_1218 1348-1416 30.7 µM 0.712284931451386 0.242789775146708 no 811 0.2381441765715 1175 6787668
SGTC_356 1634-0012 32.5 µM 0.71219599910037 0.242817300412348 no 812 0.238171707063935 1187 735457
SGTC_2471 5466956 24.79 µM 0.712127527147412 0.24283849417368 no 813 0.238192904887065 1121 724419
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.70990801254894 0.243526030618141 no 814 0.238880590676634 1187 2724 A muscle relaxant with antifungal properties.
SGTC_3222 9128301 49.47 µM 0.708611378708309 0.243928173393125 no 815 0.239282836581791 1213 4911358
SGTC_3231 9132313 49.47 µM 0.708460095236309 0.243975116334177 no 816 0.239329792318976 1158 4905967
SGTC_2855 9016525 58.44 µM 0.708350125335579 0.244009242820343 no 817 0.239363928206981 1217 43811474
SGTC_102 gallobenzophenone 83.616 µM 0.708270263184154 0.244034027712151 no 818 0.239388719979435 1187 70837
SGTC_2034 5197015 53.07 µM 0.707681135415201 0.244216903053207 no 819 0.239571647452004 1165 780676
SGTC_597 k018-0003 82.8 µM 0.707429307287442 0.244295097349413 no 820 0.239649864770875 1262 6786234
SGTC_614 0462-0418 107 µM 0.70605567281781 0.244721857389827 no 821 0.240076758181169 1071 5188303
SGTC_2733 amorolfine 100 µM 0.705037122013699 0.245038559193083 no 822 0.240393567381626 1181 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2931 9014674 55.67 µM 0.703964044249668 0.245372453616537 no 823 0.240727582788502 1185 2996810
SGTC_2071 5230951 39.92 µM 0.702651911900723 0.245781063343634 no 824 0.241136351383967 1237 1799272
SGTC_3344 9148862 3.898 µM 0.702560576856497 0.245809519484162 no 825 0.24116481903096 1208 4905352
SGTC_3276 9139060 49.47 µM 0.702341492861996 0.245877784008089 no 826 0.241233111392977 1243 4870619
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.702096688903642 0.245954074667309 no 827 0.241309433555371 1181 5379071
SGTC_2961 9083290 32.55 µM 0.701450484823155 0.246155518586921 no 828 0.241510962646197 1145 17741490
SGTC_2568 diosmetin 100 µM 0.70060337321668 0.246419726222205 no 829 0.241775286356329 1190 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1689 st020265 53.493 µM 0.700553798712225 0.246435192837016 no 830 0.241790759919528 1173 5758320 YPR016C TIF6
SGTC_881 0833-0569 170 µM 0.700226625170049 0.246537279865083 no 831 0.241892893235598 1179 5418700
SGTC_2026 5148700 152 µM 0.697818643991323 0.247289331875453 no 832 0.242645308971644 1186 79838
SGTC_2312 7706453 155.7 µM 0.697712929463415 0.247322376337625 no 833 0.242678370332281 1205 976098
SGTC_3179 9107801 49.47 µM 0.697079817188472 0.247520325251028 no 834 0.242876422086889 1204 4818259
SGTC_3271 9137798 49.47 µM 0.69676386095811 0.247619143794685 no 835 0.242975293004045 1134 6498326
SGTC_2988 9073640 71.4286 µM 0.696229390388278 0.247786352895699 no 836 0.243142592292305 1217 9102229
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.695326406068632 0.248068988415093 no 837 0.243425384730885 1221 4213774
SGTC_1828 st055811 49 µM 0.694213681460283 0.248417509387172 no 838 0.243774106932755 1162 5877589
SGTC_2840 9008771 71.43 µM 0.693846489468936 0.248532576316632 no 839 0.243889242172197 1170 2992978
SGTC_971 1315-0384 26.7 µM 0.69316984602166 0.248744690386147 no 840 0.244101484597288 1203 6769120
SGTC_788 1182-0090 188 µM 0.692573671806228 0.248931658827723 no 841 0.244288568791895 1260 5715185
SGTC_2233 sulbentine 40.3845 µM 0.691475153203224 0.249276365169679 no 842 0.244633494954758 1195 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2129 girgensonine 121.053 µM 0.690100487927386 0.249708081384475 no 843 0.245065498184219 1238 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1359 1582-0056 520 nM 0.689476827547254 0.249904073953573 no 844 0.245261625343307 1228 3661189
SGTC_2236 dapsone 200 µM 0.688868571983774 0.250095303999929 no 845 0.245452989287508 1227 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2747 doxorubicin 7.63 µM 0.686086792372175 0.250970858744648 no 846 0.246329189541223 1104 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2620 irigenin 100 µM 0.685667074782826 0.251103103981653 no 847 0.246461536898091 1235 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_251 melphalan 456.522 µM 0.684905155000142 0.251343264955959 no 848 0.246701886419332 1271 460612 A DNA alkylator.
SGTC_1105 epirubicin 18.1 µM 0.683236851012351 0.251869546547977 no 849 0.247228595122183 1182 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_493 zm226600 134 µM 0.682186942035135 0.252201047817431 no 850 0.247560375230944 1242 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1045 1348-1485 165 µM 0.681597736340829 0.252387186060022 no 851 0.247746673358516 1250 6810614
SGTC_1438 4092-1045 4 µM 0.681544541841442 0.252403994502544 no 852 0.247763496356096 1206 1351342
SGTC_752 1896-0090 130 µM 0.681334782653894 0.252470280136384 no 853 0.247829839578469 1217 772567
SGTC_698 k064-0052 127 µM 0.680919818275927 0.252601439322772 no 854 0.24796111360494 1261 5088751
SGTC_2580 diallyl disulphide 81.36 µM 0.680404830138935 0.252764263254793 no 855 0.248124081745742 1219 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2724 maprotiline 69.64 µM 0.679239484657179 0.253132914746756 no 856 0.248493066462956 1197 4011 A tricyclic antidepressant.
SGTC_3339 9145883 14.936 µM 0.678440262380031 0.253385908297388 no 857 0.24874629408263 1152 2030670
SGTC_757 1066-0008 322 µM 0.678408552738826 0.253395948714314 no 858 0.248756343879295 1223 6842497
SGTC_1860 st056228 74.6 µM 0.677969870977581 0.253534872647557 no 859 0.248895398302685 1203 688679
SGTC_1891 st059073 26.2 µM 0.677504247202664 0.253682372478273 no 860 0.249043038122741 1269 688754
SGTC_2434 5670830 169.91 µM 0.676680849817106 0.253943317740312 no 861 0.2493042346824 1213 1549830
SGTC_3163 9099914 49.47 µM 0.67643416692596 0.254021522145644 no 862 0.249382515305677 1238 16268368
SGTC_564 3555-0129 330 µM 0.675486697315614 0.254322010211398 no 863 0.249683300104964 1144 563260
SGTC_2285 7945142 200 µM 0.675191965495763 0.254415521792859 no 864 0.249776905284247 1235 2970608
SGTC_2448 5185112 27.17 µM 0.674891491900785 0.254510873652533 no 865 0.249872353196459 1217 5718189
SGTC_423 5-fluorouracil 457 µM 0.674490759476595 0.254638070636156 no 866 0.249999679274407 1206 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_552 k242-0005 476 µM 0.673940834045324 0.254812677338798 no 867 0.250174464979135 1247 4088318
SGTC_2407 paclitaxel 400 µM 0.670918073680076 0.255773551236644 no 868 0.251136360938187 1300 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3238 9133470 49.47 µM 0.670877314194539 0.255786520758823 no 869 0.251149344683251 1249 3534688
SGTC_349 k015-0014 24 µM 0.670039778161841 0.256053097706762 no 870 0.251416216486786 1218 2196908
SGTC_782 0083-0095 30.5 µM 0.669703763438974 0.256160087590173 no 871 0.25152332605865 1250 3591729 An indicator and reagent.
SGTC_2932 9016711 44.54 µM 0.669605079927198 0.256191513669351 no 872 0.251554787440569 1226 7117328
SGTC_754 3474-0146 171 µM 0.664918441511948 0.257686300180693 no 873 0.253051329869591 1191 24762078
SGTC_370 0180-0345 38.7 µM 0.663557128936357 0.258121333020975 no 874 0.253486901886384 1198 3989527
SGTC_2814 7977482 42.97 µM 0.66211301527282 0.258583242410502 no 875 0.253949397596918 1292 6456762
SGTC_1717 st033143 58.0435 µM 0.660016778600779 0.259254498484115 no 876 0.254621531055477 1278 674616
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.659873223579417 0.25930050054127 no 877 0.254667594337624 1278 279621
SGTC_1294 1000-1494 117 µM 0.659130784471534 0.259538481679717 no 878 0.254905894452195 1232 712797 YDL207W GLE1
SGTC_841 0251-0215 91.2 µM 0.657476324971368 0.260069206884443 no 879 0.255437344529562 1287 3888614
SGTC_3199 9111318 49.47 µM 0.657253457172259 0.260140742192482 no 880 0.255508978967289 1223 8548020
SGTC_2606 farnesol 9.78 µM 0.656965964998495 0.26023303537935 no 881 0.255601400548735 1282 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3324 9138759 60.749 µM 0.656268216784071 0.260457102608799 no 882 0.255825781832973 1262 45595710
SGTC_1827 berberine 7.24 µM 0.656183286032398 0.260484383122741 no 883 0.255853100809907 1177 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2017 5132927 60.65 µM 0.653301003301793 0.261411069515672 no 884 0.256781122870788 1229 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_982 1491-0518 27.5 µM 0.653203996447783 0.261442287736523 no 885 0.256812387071264 1235 3091256
SGTC_3350 9150499 3.57 µM 0.651386630865999 0.262027496177189 no 886 0.257398469268782 1239 4910996 YPR165W RHO1
SGTC_1807 st050092 58.9 µM 0.650395985036117 0.262346775787539 no 887 0.257718235045393 1235 5008496
SGTC_2537 larixol 68.93 µM 0.650365655899346 0.26235655384104 no 888 0.257728028093147 1255 6708759
SGTC_1695 st026914 34.495 µM 0.649689751210328 0.262574512586971 no 889 0.257946322692053 1251 3289191
SGTC_1287 0971-0001 34.6 µM 0.64866744293109 0.262904351968376 no 890 0.258276676222207 1273 4665869
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.647273213235223 0.263354529961623 no 891 0.258727567390849 1256 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1343 1487-0095 224 µM 0.647166432030511 0.263389024394264 no 892 0.258762117013983 1265 4560101 YGL055W OLE1
SGTC_1663 st014140 55.4 µM 0.646737066481757 0.263527749248219 no 893 0.258901064606599 1334 4207120
SGTC_1023 4482-3888 16 µM 0.646595979958418 0.263573341405165 no 894 0.258946730240111 1282 3303168
SGTC_990 3985-0011 41.3 µM 0.645912535153434 0.263794253778439 no 895 0.259168000549198 1258 5399565 YGL099W LSG1
SGTC_383 2324-0395 7.37 µM 0.644772266094576 0.264163037188054 no 896 0.259537388540376 1284 3146421
SGTC_1298 1079-1278 263 µM 0.642945946499781 0.264754248257859 no 897 0.260129587217258 1297 2840950
SGTC_1203 3992-3522 103 µM 0.642200518705541 0.264995749253069 no 898 0.260371498134449 1476 5322312
SGTC_3009 9080819 71.4286 µM 0.640608073190673 0.265512038670934 no 899 0.260888676513641 1268 17027216
SGTC_1263 0774-1208 64.8 µM 0.640546431046358 0.265532034027383 no 900 0.260908706643969 1312 906585
SGTC_2319 6033012 152.6 µM 0.639473263754382 0.265880268271846 no 901 0.261257550625201 1235 847246
SGTC_2261 9010538 184.68 µM 0.638812855644869 0.266094680416316 no 902 0.261472342067675 1216 6457250
SGTC_65 0798-0905 34.986 µM 0.638765763626219 0.266109972943611 no 903 0.261487661760399 1456 3602145
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.638691349135141 0.266134138999618 no 904 0.261511870775236 1327 1377
SGTC_1227 3909-8010 46.6 µM 0.637934868255922 0.266379868707984 no 905 0.261758039432065 1286 15982272
SGTC_94 0334-0113 514.748 µM 0.637177476543197 0.266626009241408 no 906 0.262004623526647 1239 6795178
SGTC_1428 4049-0204 61.7 µM 0.637176578357757 0.266626301205966 no 907 0.262004916019647 1328 X1428
SGTC_3269 9137823 49.47 µM 0.636736412784139 0.266769401070042 no 908 0.26214827554426 1224 17682936
SGTC_1727 st034309 9.9045 µM 0.635565442304963 0.267150277872861 no 909 0.262529849842554 1355 870305
SGTC_2376 9072922 81.32 µM 0.635124961911317 0.267293622156303 no 910 0.262673459030018 1313 17087968
SGTC_3322 9139058 2.11 µM 0.634869818181151 0.267376670602609 no 911 0.262756661551744 1337 4908926 YPR165W RHO1
SGTC_3205 9113483 49.47 µM 0.63122675415212 0.268563893983898 no 912 0.263946135516398 1299 17018033
SGTC_2474 5321570 43.32 µM 0.631118421106495 0.268599238726794 no 913 0.263981548633344 1334 2841384
SGTC_812 4251-0442 148 µM 0.629480506681905 0.269133909445335 no 914 0.264517263316359 1281 5723007
SGTC_655 k060-0012 42 µM 0.628405638576467 0.269485072760816 no 915 0.264869122125175 1265 5994525
SGTC_2345 9052315 157.45 µM 0.62697364464791 0.269953266884581 no 916 0.265338255626803 1303 6469265
SGTC_2807 7945238 51.95 µM 0.626630125585684 0.270065641845332 no 917 0.265450858109744 1340 17148797
SGTC_196 k015-0023 18.111 µM 0.626393416873566 0.270143089687495 no 918 0.265528463220716 1301 5211998
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.625899016539817 0.270304886517098 no 919 0.265690589818761 1294 115019
SGTC_1849 st056239 19.2 µM 0.622273218804488 0.271492938974393 no 920 0.26688111402581 1230 5393181
SGTC_2994 9053520 71.4286 µM 0.619845419230746 0.272289898838187 no 921 0.267679781417176 1329 4647384
SGTC_2811 7967822 32.47 µM 0.619575735935189 0.272378497908988 no 922 0.267768572760135 1349 2232244
SGTC_519 k048-0011 62.8 µM 0.619232468522324 0.272491292285006 no 923 0.267881612621912 1325 6836379
SGTC_1160 4092-0570 10.5 µM 0.618301316022391 0.272797376799065 no 924 0.268188367282577 1299 4994975
SGTC_721 1187-1332 279 µM 0.617541046533931 0.27304741579053 no 925 0.268438958029798 1250 25730
SGTC_1013 4112-3890 241 µM 0.617214388295201 0.273154882703712 no 926 0.268546663279198 1272 705171
SGTC_291 SEC14.278 35.5 µM 0.615374546905238 0.273760561165286 no 927 0.269153698363991 1321 1068044
SGTC_1745 st081495 74 µM 0.615298852472468 0.273785494101367 no 928 0.269178687632025 1279 13842402 YBL026W LSM2
SGTC_1161 k007-0610 110 µM 0.615176107010506 0.273825927529812 no 929 0.26921921249492 1376 5843850
SGTC_1624 st003710 6.25 µM 0.615119521452362 0.273844568301748 no 930 0.269237895454317 1337 24207033
SGTC_253 dyclonine 31.25 µM 0.61483824661743 0.273937236944429 no 931 0.269330774141473 1380 3180 An oral anasthetic.
SGTC_2517 totarol 10 µM 0.614388591530512 0.274085412236671 no 932 0.269479286391923 1272 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3095 9117207 49.47 µM 0.614033466921806 0.274202464786336 no 933 0.269596606082613 1288 17015229
SGTC_1803 st050068 52.4 µM 0.613941716618071 0.2742327105981 no 934 0.269626921059665 1397 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_560 2332-1943 155 µM 0.612439502995892 0.274728154820966 no 935 0.270123506271353 1319 21177716
SGTC_3159 9100096 49.47 µM 0.612328237049209 0.274764868927943 no 936 0.27016030553061 1268 25236875
SGTC_315 k915-0449 187 µM 0.611775892206616 0.274947160381021 no 937 0.270343021005338 1364 20970215 YNL149C PGA2
SGTC_1323 1348-1351 11.2 µM 0.611516858070595 0.275032670447314 no 938 0.270428730676928 1321 6989654
SGTC_161 4065-0411 162.148 µM 0.610941380697984 0.275222688834613 no 939 0.270619194229191 1339 1906281 YLR208W SEC13
SGTC_3213 9129884 49.47 µM 0.610885577766969 0.275241117988032 no 940 0.270637666675299 1239 17190742
SGTC_1205 4161-2785 76 µM 0.610870269929272 0.275246173572198 no 941 0.270642734139389 1289 3498106
SGTC_424 splitomicin 100 mM 0.607311469187133 0.276422746274891 no 942 0.271822114177637 1286 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2125 5246583 200 µM 0.606793353885303 0.276594245490949 no 943 0.271994029656221 1371 835267
SGTC_294 k038-0071 157 µM 0.605280900553599 0.277095174583889 no 944 0.272496184859136 1322 24152826
SGTC_3002 9075603 71.4286 µM 0.603612676249926 0.277648209894671 no 945 0.273050591530728 1308 20105405
SGTC_681 1642-0006 26.6 µM 0.602924372452625 0.277876547450056 no 946 0.27327950070462 1330 4446530
SGTC_2242 6630449 61.2675 µM 0.600594172136237 0.278650246698887 no 947 0.274055160275917 1360 691249 YDR170C SEC7
SGTC_2455 5377712 9.75 µM 0.598544294334768 0.279331736240002 no 948 0.274738406421331 1287 2243908
SGTC_1900 st060200 72.8 µM 0.598510518407946 0.27934297195105 no 949 0.274749671327711 1346 688945
SGTC_2224 6650123 117.647 µM 0.596261101601838 0.28009174420021 no 950 0.275500406302096 1317 2908370
SGTC_3118 9124250 49.47 µM 0.596049040903472 0.280162383825145 no 951 0.275571232827125 1291 1504786
SGTC_1511 0906-3109 28.5 µM 0.595906820717091 0.280209763684441 no 952 0.275618738212656 1362 2882180
SGTC_1780 st038448 24.544 µM 0.59087481245337 0.281888642776949 no 953 0.277302151774982 1444 728868 YDL195W SEC31
SGTC_1097 itavastatin 7.23 µM 0.588347856541992 0.282733560384877 no 954 0.278149414805847 1369 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1374 2889-5571 141 µM 0.588137752098365 0.28280386604666 no 955 0.27821991753531 1353 2853281
SGTC_1108 betulinic acid 729.144 nM 0.58762747434047 0.282974651392503 no 956 0.278391182811471 1354 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1370 2001-0092 44.6 µM 0.587411634282138 0.283046906004581 no 957 0.278463640987634 1500 790957
SGTC_505 gw-5074 63.9 µM 0.587276663090545 0.28309209345666 no 958 0.278508955903726 1412 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2403 6032726 181.2 µM 0.586807802357925 0.28324909178946 no 959 0.278666398031537 1359 2881040
SGTC_3148 9097893 49.47 µM 0.586022661900252 0.283512090085881 no 960 0.278930143015499 1254 17174100
SGTC_1277 0873-0036 22 µM 0.585689283634166 0.283623797101599 no 961 0.27904216841567 1441 5965735
SGTC_1704 st028805 70.8 µM 0.584261620296616 0.284102410987886 no 962 0.279522154747583 1355 2876101
SGTC_667 1498-1044 59 µM 0.583560816072262 0.284337491842371 no 963 0.279757914636075 1391 6739982
SGTC_1958 st076513 41.9 µM 0.582620698098747 0.284652995080438 no 964 0.280074334304814 1310 732122 YGL099W LSG1
SGTC_556 4058-0063 51.5 µM 0.582040319428707 0.284847853346654 no 965 0.280269761482365 1398 6615692
SGTC_1568 digitonin 820 nM 0.58114942692485 0.285147088324189 no 966 0.280569874437296 1458 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1467 k284-1082 293 µM 0.57956806602745 0.285678608081075 no 967 0.281102966611082 1420 3334705
SGTC_3214 9129694 49.47 µM 0.578660319389774 0.285983928513512 no 968 0.281409197735727 1405 17158655
SGTC_442 cape 100 µM 0.577894166481431 0.286241744548892 no 969 0.281667786995877 1430 5281787
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.573942264545451 0.287573338219472 no 970 0.283003435710292 1366 521171
SGTC_2092 5303694 80.6725 µM 0.573590035435631 0.287692163838947 no 971 0.283122628171761 1353 1963699
SGTC_2809 7964133 12.99 µM 0.57324219683992 0.287809531069033 no 972 0.283240358541664 1408 1253665
SGTC_300 r073-0011 5.04 µM 0.572911036540812 0.287921291742834 no 973 0.283352465747105 1403 2735780
SGTC_2127 5253358 187.912 µM 0.572437373015753 0.288081180311388 no 974 0.283512851327721 1334 20612
SGTC_1671 st016596 74.5 µM 0.57242494466916 0.288085376154279 no 975 0.283517060233189 1377 2829167
SGTC_1740 st038286 13.222 µM 0.572419497722806 0.288087215066956 no 976 0.283518904871124 1413 716786
SGTC_2652 actinonin 100 µM 0.572062661256869 0.288207696669583 no 977 0.28363976200484 1358 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_455 paf C-16 10 µM 0.571672758283758 0.288339369954241 no 978 0.283771846660143 1364 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2555 cholic acid 100 µM 0.567275204020418 0.289826418793878 no 979 0.285263610420786 1380 6708657 Influences liver metabolism.
SGTC_793 0488-0545 106 µM 0.566851557102497 0.28996986630802 no 980 0.285407519454622 1345 292548
SGTC_2626 ethyl orsellinate 100 µM 0.566823312994515 0.28997943099105 no 981 0.285417114952301 1345 75653 A natural product.
SGTC_933 2914-0560 114 µM 0.56576766847187 0.290337024163146 no 982 0.285775863932763 1458 463887
SGTC_2317 5986382 200 µM 0.565655578218113 0.290375006180134 no 983 0.285813969143211 1475 877883
SGTC_768 0384-0033 77.3 µM 0.565422537118364 0.290453980089999 no 984 0.285893199465614 1365 3965305 YMR134W ERG29
SGTC_250 brefeldin a 552.239 µM 0.565140945613843 0.290549420369195 no 985 0.285988950094516 1328 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1477 0139-0234 16 µM 0.564961059622751 0.290610397109387 no 986 0.286050125388534 1393 620880
SGTC_1481 3346-2004 36 µM 0.564188273480987 0.290872419884994 no 987 0.286313003776752 1376 2770522
SGTC_615 k087-0205 167 µM 0.564141972297489 0.29088812238413 no 988 0.286328757675057 1342 9642773
SGTC_629 3448-6466 76.7 µM 0.56395969403631 0.290949943751788 no 989 0.286390781539523 1377 573744
SGTC_2933 9026794 32.47 µM 0.563605689173915 0.291070025330732 no 990 0.286511257068126 1440 17586027
SGTC_1618 st003135 44.5 µM 0.562348560941233 0.291496641298822 no 991 0.286939279248865 1359 1270615
SGTC_677 0929-0063 136 µM 0.56187999530547 0.291655727163275 no 992 0.287098892134569 1370 1539583
SGTC_2697 mebhydrolin 72.4 µM 0.56048794417115 0.29212859034872 no 993 0.28757333028474 1471 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.557006705003752 0.293312684876565 no 994 0.288761424051538 1458 6710655
SGTC_2394 5221648 200 µM 0.554922553626371 0.294022642436324 no 995 0.289473817279456 1539 788586
SGTC_2110 5483698 200 µM 0.553238233802545 0.294596978809537 no 996 0.290050144701035 1412 2848765 YHR062C RPP1
SGTC_1744 st037937 38.9 µM 0.55285621476427 0.294727315492293 no 997 0.290180935787736 1455 1016152
SGTC_187 1488-2104 32.728 µM 0.552433336290816 0.294871623537633 no 998 0.290325748052624 1467 2852859
SGTC_3116 9124943 49.47 µM 0.552162351927582 0.294964114560319 no 999 0.290418562854434 1316 41905195 YPL160W CDC60
SGTC_1423 4048-0112 5.59 µM 0.550303001903949 0.295599098786703 no 1000 0.291055782807012 1452 X1423
SGTC_1144 3486-0183 12.5 µM 0.5500758455151 0.295676717728905 no 1001 0.291133676577549 1395 6744069
SGTC_1273 0849-0096 14.1 µM 0.546977964508926 0.29673619190303 no 1002 0.292196935488364 1401 5286025
SGTC_1448 4255-0083 152 µM 0.546727443763926 0.296821945819019 no 1003 0.292282998459981 1547 5399660
SGTC_1675 st018485 24.5 µM 0.544759038847483 0.297496130386115 no 1004 0.292959626919085 1438 3323024
SGTC_2879 9041815 71.43 µM 0.544494807326999 0.297586683674749 no 1005 0.293050510368725 1380 4942971
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.542940964841629 0.298119446580778 no 1006 0.293585224885588 1377 6708760
SGTC_1460 k062-0059 9.15 µM 0.541064835848661 0.298763289639176 no 1007 0.294231447260403 1386 1373085
SGTC_404 fumagillin 50 µM 0.541029958231727 0.298775264793306 no 1008 0.294243466883818 1428 12015870 A methionine aminopeptidase binder.
SGTC_1876 myriocin 605 nM 0.540100985243825 0.299094305908077 no 1009 0.294563695635234 1515 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2254 7938975 95.19 µM 0.539886775741399 0.299167894718805 no 1010 0.294637559171732 1506 2969277
SGTC_2041 5107442 45.335 µM 0.539730990855181 0.299221417694205 no 1011 0.29469128214792 1456 793005
SGTC_2925 9010536 32.5 µM 0.539103323846981 0.299437109101553 no 1012 0.294907781121066 1501 2994177
SGTC_923 1900-2434 73.3 µM 0.538753311091081 0.299557418046197 no 1013 0.295028541615204 1381 5910570
SGTC_3290 9121031 71.43 µM 0.538698690824069 0.299576194499782 no 1014 0.295047388612739 1392 17014854
SGTC_1929 genistein trimethyl ether 50.5 µM 0.538586178025094 0.299614873972944 no 1015 0.295086213466957 1541 136420
SGTC_1246 0422-0085 105 µM 0.537544972022304 0.299972925446462 no 1016 0.295445614587282 1446 264295
SGTC_2225 6654152 15.4 µM 0.537089267187724 0.300129694797837 no 1017 0.295602977065783 1448 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1133 3473-0247 50 µM 0.536744476194127 0.300248332728563 no 1018 0.295722064744471 1375 711311
SGTC_2680 butyl paraben 22.24 µM 0.536609347566764 0.300294834448444 no 1019 0.295768742957831 1446 7184 An antifungal and steroid mimetic.
SGTC_2256 7954252 200 µM 0.535319100249259 0.300739010182197 no 1020 0.296214610443563 1378 2972920
SGTC_1665 st014639 11.4 µM 0.534726758615915 0.300943026751514 no 1021 0.296419407647544 1492 981133 YIL048W NEO1
SGTC_2869 9037858 32.47 µM 0.532730704284052 0.301630974413771 no 1022 0.297110004236407 1371 27187042
SGTC_2476 5806916 10.51 µM 0.532154635766233 0.30182965004774 no 1023 0.297309449626826 1444 2870194
SGTC_2064 5220758 200 µM 0.532023803468915 0.301874779939788 no 1024 0.297354754668767 1466 788518
SGTC_2756 carbadox 75.1 µM 0.529949713547732 0.302590630680974 no 1025 0.298073398317 1426 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_874 0599-0792 117 µM 0.52986379399851 0.30262030133129 no 1026 0.298103185323263 1516 765305
SGTC_2252 omeprazole 400 µM 0.528152158167216 0.303211653042254 no 1027 0.29869686593152 1458 4594 A proton pump inhibitor.
SGTC_2767 sibutramine 71.45 µM 0.526846450605666 0.303663108020061 no 1028 0.299150111477639 1528 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2293 7624732 200 µM 0.526165064787097 0.303898819686403 no 1029 0.299386762361015 1385 894453
SGTC_2761 levamisole 97.89 µM 0.526024122882835 0.303947585875605 no 1030 0.299435723234769 1541 26879 An alkaline phosphatase inhibitor.
SGTC_469 w7 172 µM 0.525397965405067 0.304164279825628 no 1031 0.299653283807136 1473 45115570 A P450 inhibitor.
SGTC_3314 9135860 59.4275 µM 0.525156128953234 0.30424799044593 no 1032 0.299737329881744 1443 25252478
SGTC_3340 9146634 11.102 µM 0.5250218529321 0.304294473927896 no 1033 0.299783999798795 1447 4907387
SGTC_2974 9094440 9.66 µM 0.522722070534735 0.305091099724506 no 1034 0.300583838575593 1547 25236134
SGTC_2178 5812956 200 µM 0.522550848000307 0.305150446827926 no 1035 0.300643426390959 1458 5403383
SGTC_803 4488-1585 147 µM 0.522456328734353 0.305183210158452 no 1036 0.300676322689755 1461 747204
SGTC_481 bay k-8644 50 µM 0.522398418738722 0.305203284343429 no 1037 0.30069647837293 1403 2303 A calcium channel antagonist.
SGTC_673 1082-0474 110 µM 0.5202621551169 0.305944217617551 no 1038 0.301440434679375 1430 3098046
SGTC_1019 4262-0212 3.4 µM 0.5181368666354 0.306682133170936 no 1039 0.302181389825133 1485 4677213
SGTC_463 ikarugamyin 104 µM 0.517062493330376 0.307055462004081 no 1040 0.302556267403777 1493 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_142 0335-0849 62.6745 µM 0.517004346925115 0.307075672731664 no 1041 0.302576562184518 1496 3889043 YPR107C YTH1
SGTC_2032 5185112 25.99 µM 0.512654765910934 0.308589173503232 no 1042 0.304096418305677 1432 5718189
SGTC_558 k064-0027 21.3 µM 0.512247631553608 0.308731009028866 no 1043 0.304238855561597 1538 5088526
SGTC_2831 7999036 19.48 µM 0.51174867167704 0.308904873206311 no 1044 0.304413458782463 1632 2988270
SGTC_3176 9106582 49.47 µM 0.509442640377904 0.309708973132603 no 1045 0.305220997187724 1416 17018027
SGTC_3019 9081971 49.47 µM 0.508337456769901 0.310094667696394 no 1046 0.305608352987354 1574 16451803
SGTC_1762 st045503 25.4615 µM 0.507953968865809 0.310228548811177 no 1047 0.305742812550624 1470 4645554
SGTC_75 0159-0059 199.013 µM 0.507041396079434 0.310547242160889 no 1048 0.306062886589443 1568 5377270
SGTC_2742 clothiapine 36.27 µM 0.506566443763409 0.310713163743714 no 1049 0.306229529083715 1533 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.505754522070206 0.310996892604869 no 1050 0.306514494015891 1422 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2139 5578692 56.4705 µM 0.503511432208339 0.311781331888381 no 1051 0.307302372355592 1518 650991 YMR113W FOL3
SGTC_2400 5203494 178.7 µM 0.503438417003482 0.311806880689131 no 1052 0.307328033697973 1428 6777674
SGTC_807 1315-0151 48 µM 0.503383053292149 0.311826253647337 no 1053 0.307347492015823 1586 4011080
SGTC_219 mitoxanthrone 164.414 µM 0.502765508097979 0.31204238133235 no 1054 0.307564573295415 1526 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_993 3909-8757 62.7 µM 0.501841242842124 0.31236597542056 no 1055 0.30788959962838 1484 4288324 YLR208W SEC13
SGTC_2283 7944793 200 µM 0.501723577495688 0.312407181574278 no 1056 0.307930988548742 1407 2970533
SGTC_2051 5263410 176 µM 0.501600730440632 0.312450204854477 no 1057 0.307974202748302 1495 227584
SGTC_275 trichlorophene 5.69 µM 0.500994167586731 0.31266267170017 no 1058 0.308187613825559 1520 62616
SGTC_1936 st074407 74.3 µM 0.500983845599459 0.312666287825043 no 1059 0.308191246041017 1473 809813
SGTC_545 4218-0007 221 µM 0.499054074754067 0.313342665271511 no 1060 0.308870644924302 1470 2840508
SGTC_951 1171-0579 82.7 µM 0.498443700102861 0.313556730200459 no 1061 0.309085670973472 1409 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2821 7996764 71.43 µM 0.498049849269338 0.313694891249232 no 1062 0.309224453587378 1538 2987135
SGTC_612 0302-0167 22.4 µM 0.497089926488156 0.314031737154998 no 1063 0.309562818990613 1572 235821
SGTC_3184 9108758 49.47 µM 0.495383753523361 0.314630831717038 no 1064 0.310164630316332 1496 902885
SGTC_1194 1488-0194 225 µM 0.494998819657269 0.314766062482266 no 1065 0.310300476847346 1495 1391452
SGTC_2646 retinol 96.75 µM 0.493923269023785 0.31514404484125 no 1066 0.310680185249279 1502 445354 A vitamin A analog and teratogen.
SGTC_1176 0848-0131 83.3 µM 0.493630402237473 0.315247001007824 no 1067 0.310783612816468 1561 6769040
SGTC_39 0986-0283 58.349 µM 0.491563929462813 0.315973868873433 no 1068 0.311513824016485 1623 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_163 TUB2.036 7.546 µM 0.490540146806229 0.316334241471056 no 1069 0.311875864093331 1505 15992207 YJR013W GPI14
SGTC_3241 9133421 49.47 µM 0.489946589300786 0.316543254286948 no 1070 0.312085847030766 1520 17018221
SGTC_1076 itraconazole 331 nM 0.488946968652301 0.316895388874918 no 1071 0.312439621004136 1495 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1049 3226-0134 66 µM 0.488709810310727 0.316978956587417 no 1072 0.312523578686774 1511 5702385
SGTC_1884 5633444 25 µM 0.486834429714645 0.317640114806106 no 1073 0.31318783456696 1516 5724239
SGTC_2196 6573537 42.6665 µM 0.486400754273511 0.317793088347571 no 1074 0.313341527941511 1582 2903087
SGTC_1694 st024011 44.9 µM 0.482304689765128 0.31923945473751 no 1075 0.314794758121046 1538 2787533
SGTC_593 1203-0218 61.7 µM 0.481567043125272 0.319500219483795 no 1076 0.315056771420005 1589 3666956
SGTC_2059 5238311 157 µM 0.478923433068807 0.320435492120443 no 1077 0.315996549917066 1489 703021
SGTC_99 0109-0120 622.8 µM 0.478620172255718 0.320542854694078 no 1078 0.316104432500886 1586 759414
SGTC_2155 5570423 76 µM 0.477803367351523 0.320832100515049 no 1079 0.316395082115428 1512 797402
SGTC_850 0388-0143 75.9 µM 0.476961060506136 0.32113049099174 no 1080 0.316694925092296 1486 67273
SGTC_3193 9111931 49.47 µM 0.476026137586174 0.321461826354244 no 1081 0.317027878462589 1549 17087244
SGTC_321 4534-3890 65.3 µM 0.475323513444029 0.321710928905876 no 1082 0.317278201011385 1568 699746
SGTC_2433 5607874 27.82 µM 0.474984115065445 0.321831285122341 no 1083 0.317399147773344 1472 2252428
SGTC_2592 piperlongumine 83.33 µM 0.474559933161089 0.321981733247597 no 1084 0.317550335094658 1441 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_534 k292-0788 63.4 µM 0.471253317380254 0.32315551696554 no 1085 0.318729924030872 1608 4146317
SGTC_1921 5740136 50 µM 0.471197269126071 0.323175428222657 no 1086 0.318749934344654 1641 1774243
SGTC_3209 9113616 49.47 µM 0.470895067801552 0.323282794590799 no 1087 0.318857835183893 1695 16649353
SGTC_2829 7992743 58.44 µM 0.470394163022303 0.323460788924639 no 1088 0.319036716814092 1645 16462845
SGTC_271 rotenone 740 µM 0.470165130365552 0.323542188146715 no 1089 0.319118522323321 1554 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_912 3474-0017 2.18 µM 0.470113471955508 0.323560548942036 no 1090 0.319136974807318 1620 3360550
SGTC_1377 2944-0135 198 µM 0.469665863172979 0.323719659185293 no 1091 0.3192968802901 1578 1894137
SGTC_2820 7989630 71.43 µM 0.469407160039507 0.323811634362331 no 1092 0.319389315724864 1523 2984098
SGTC_343 4130-2827 29.8 µM 0.468751735611299 0.324044701640403 no 1093 0.319623551149184 1505 1118244
SGTC_1895 st058434 18.3 µM 0.468718812925909 0.324056410684895 no 1094 0.319635318949724 1625 5393175
SGTC_2563 tomatine 8.54 µM 0.467752597361027 0.324400125406363 no 1095 0.319980761400022 1731 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1587 estradiol valerate 56.1 µM 0.467162756003062 0.324610025006675 no 1096 0.320191718908518 1589 13791 A steroid.
SGTC_3265 9137266 49.47 µM 0.466766782836708 0.324750966377184 no 1097 0.320333371831454 1639 17224265
SGTC_2420 aureobasidin a 50 nM 0.466604573292682 0.324808709948786 no 1098 0.320391407203407 1665 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3077 9117319 49.47 µM 0.466012797986869 0.32501940660491 no 1099 0.320603169959302 1538 17154678
SGTC_3039 9090270 49.47 µM 0.465239502795565 0.325294816255065 no 1100 0.320879976386883 1596 17173750
SGTC_3053 9095903 49.47 µM 0.464853284155584 0.325432404057405 no 1101 0.321018263357305 1584 17174018
SGTC_2872 9044037 25.97 µM 0.464778735718284 0.3254589641788 no 1102 0.321044958552241 1619 6465195
SGTC_2923 7992654 58.14 µM 0.463992575135309 0.325739111455245 no 1103 0.321326532612284 1530 2985126
SGTC_3280 9140961 49.47 µM 0.463954004889411 0.325752858445431 no 1104 0.321340349713001 1521 4901226
SGTC_3212 9128307 49.47 µM 0.460581147428977 0.326955907852619 no 1105 0.322549569967719 1440 27243542
SGTC_3204 9114183 49.47 µM 0.460243776862335 0.327076342316373 no 1106 0.322670626007361 1516 17027248
SGTC_2582 agaric acid 100 µM 0.458415739473403 0.327729227571911 no 1107 0.323326892961751 1446 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.457953722291687 0.327894320945443 no 1108 0.323492844683997 1501 2374 Ca(2+)-ATPase inhibitor.
SGTC_966 1300-0360 30.2 µM 0.457847500530949 0.327932282102308 no 1109 0.32353100339139 1545 70588
SGTC_1645 Cervolide 78 µM 0.455510293978188 0.328767994021414 no 1110 0.324371081768372 1539 23173 A fragrance.
SGTC_538 2922-0838 53.3 µM 0.455304536218742 0.328841607659072 no 1111 0.324445081617942 1669 777039
SGTC_733 4069-0007 56.1 µM 0.453808308007462 0.329377110488983 no 1112 0.324983401692238 1579 5717425 YNL287W SEC21
SGTC_1398 3558-0053 112 µM 0.452277100266335 0.329925495122538 no 1113 0.325534685425795 1516 4532369
SGTC_1711 st032263 62.8 µM 0.452029581451015 0.330014175537237 no 1114 0.325623835996289 1588 3958979
SGTC_209 4077-0173 175.592 µM 0.451605675597999 0.330166073640962 no 1115 0.325776540279537 1545 15993494
SGTC_1078 idebenone 36.1 µM 0.44958843274315 0.330889295145135 no 1116 0.32650361511802 1549 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_870 0573-2213 57.6 µM 0.44934878834925 0.330975254430042 no 1117 0.326590034033534 1511 3916321
SGTC_2147 5545932 89.7195 µM 0.449298411136522 0.330993325626228 no 1118 0.326608201901957 1561 797404
SGTC_1311 1190-0148 100 µM 0.448401332439687 0.331315189504063 no 1119 0.326931790169312 1651 1961333
SGTC_316 k060-0003 58.6 µM 0.448030241756481 0.331448370008531 no 1120 0.327065685613506 1601 6152314
SGTC_1313 1220-0047 237 µM 0.446216731224059 0.332099526031099 no 1121 0.327720349149118 1615 3528706
SGTC_329 k048-0121 21.3 µM 0.444301527829063 0.332787746543831 no 1122 0.328412298392704 1558 6832902
SGTC_1480 1070-0044 41.2 µM 0.444187151074054 0.332828865226159 no 1123 0.328453640553328 1609 3124987
SGTC_2156 5649887 115 µM 0.44333998852478 0.333133484502117 no 1124 0.328759917876946 1648 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2536 dehydroabietamide 32.04 µM 0.443276614941542 0.333156276547893 no 1125 0.328782834154033 1680 3983547
SGTC_2458 5808907 16.39 µM 0.439351044181611 0.334569290166074 no 1126 0.33020359673865 1615 2731747
SGTC_2018 5133068 143 µM 0.437006097358618 0.335414477287589 no 1127 0.331053463049354 1550 785362
SGTC_2641 levomentholum 100 µM 0.436080620286332 0.335748275849934 no 1128 0.331389118686253 1564 16666
SGTC_2976 9009005 19.48 µM 0.43607593634196 0.335749965572217 no 1129 0.331390817822282 1716 2993148
SGTC_1180 1193-0155 285 µM 0.43596889964263 0.335788579723085 no 1130 0.331429647135317 1538 2921347
SGTC_278 4092-0821 23.9 µM 0.435361703627221 0.336007662242304 no 1131 0.33164995170369 1609 877900
SGTC_946 3434-1334 87.4 µM 0.434610272913484 0.336278863262651 no 1132 0.331922668546305 1657 4047976
SGTC_1348 1493-0373 93.8 µM 0.434435345130318 0.336342009185757 no 1133 0.331986167895129 1603 3010129
SGTC_1376 2910-0861 41.3 µM 0.433762433414776 0.336584961776798 no 1134 0.332230481989436 1602 1112859
SGTC_379 3970-0972 5.9 µM 0.433729404686312 0.336596888449495 no 1135 0.332242475568731 1600 2898042 YBL034C STU1
SGTC_1520 flindersine 88 µM 0.433140624255557 0.336809524615181 no 1136 0.332456305680656 1735 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1276 0871-0068 94.2 µM 0.431840107551998 0.337279386873907 no 1137 0.332928813539828 1654 3414906
SGTC_2899 9053889 58.44 µM 0.431181786337975 0.337517327865482 no 1138 0.333168098126517 1629 6470052
SGTC_2036 5160441 105 µM 0.431033591310994 0.337570899847799 no 1139 0.333221972973195 1610 134534 YIL048W NEO1
SGTC_1050 3232-1156 69.3 µM 0.430483152696869 0.337769910289402 no 1140 0.33342210964849 1542 700529
SGTC_573 3702-0553 84.7 µM 0.429809386900062 0.338013571277929 no 1141 0.333667152013183 1569 1222756
SGTC_1156 4092-0367 4.88 µM 0.428902062417915 0.338341803786036 no 1142 0.333997249626615 1609 1357585
SGTC_825 1988-2224 89.6 µM 0.428490404834841 0.338490765028468 no 1143 0.334147058922642 1582 1180859
SGTC_2358 9037157 4 µM 0.428032107684216 0.338656632864409 no 1144 0.334313872249184 1622 2388925
SGTC_1844 rapamycin 4 nM 0.427249521484894 0.338939940391441 no 1145 0.334598797591173 1586 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1992 st073643 23.3 µM 0.42677961200022 0.339110098217977 no 1146 0.334769928845207 1592 3161292
SGTC_2186 6124449 200 µM 0.426668394988304 0.339150375555373 no 1147 0.334810436790453 1631 3834182 YLR033W RSC58
SGTC_259 usnic acid 108.925 µM 0.426247342650132 0.33930287667523 no 1148 0.334963811720734 1649 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1353 1498-1206 8.11 µM 0.421804210382014 0.340913736957907 no 1149 0.336583966125146 1572 6756808
SGTC_601 0986-0029 62.9 µM 0.421458459326005 0.341039211396663 no 1150 0.33671016941221 1590 24747981
SGTC_418 lividomycin a 100 µM 0.421275476006757 0.341105623889701 no 1151 0.336776967964096 1667 72394 An antibiotic.
SGTC_1932 st074806 40.9 µM 0.4212236303049 0.341124441813198 no 1152 0.336795895313022 1667 17251235
SGTC_2174 5790901 200 µM 0.418183667570184 0.342228516630888 no 1153 0.337906418040496 1601 786020
SGTC_2478 5763493 32.33 µM 0.417175329709374 0.342595030419946 no 1154 0.338275084348989 1658 1365576 YLR208W SEC13
SGTC_882 0843-0131 351 µM 0.414621607020457 0.343523927999292 no 1155 0.339209464085412 1628 5425421
SGTC_3306 9127676 59.7925 µM 0.414511927172088 0.343563844447868 no 1156 0.339249616971359 1582 41905287
SGTC_3136 9095672 49.47 µM 0.411869357773188 0.344526097109045 no 1157 0.340217590704752 1706 17217380
SGTC_1286 0929-0070 131 µM 0.411483212840819 0.34466679056058 no 1158 0.340359124079207 1682 1420408
SGTC_2065 5221596 34.26 µM 0.411056467445101 0.344822301948974 no 1159 0.340515564868032 1632 788581
SGTC_244 nsc-207895 1.295 µM 0.410834228501052 0.344903298999725 no 1160 0.340597046413055 1538 42640
SGTC_1362 1611-0397 101 µM 0.410682556206884 0.34495858145957 no 1161 0.340652659718075 1601 27816
SGTC_1415 3966-0071 78.1 µM 0.41067950086957 0.344959695121903 no 1162 0.340653780046651 1628 2893185
SGTC_864 0469-0573 172 µM 0.409626206916042 0.345343697950363 no 1163 0.341040084724084 1589 689425
SGTC_2057 5236571 38.335 µM 0.409077605735483 0.345543766381494 no 1164 0.34124135500686 1718 54684039 YBR257W POP4
SGTC_2336 9001819 198.65 µM 0.4087432522708 0.34566572234673 no 1165 0.3413640444493 1705 2989602
SGTC_2122 5258151 111.688 µM 0.40783125206899 0.345998457295089 no 1166 0.341698783879588 1589 2173356
SGTC_2303 7774051 200 µM 0.407727540127463 0.346036303187258 no 1167 0.341736858072896 1686 2953184
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.407373765320132 0.346165411974924 no 1168 0.341866746167423 1576 61125 An anti-inflammatory.
SGTC_328 k915-0120 63.5 µM 0.405702132143799 0.346775709876831 no 1169 0.342480737735424 1705 6624543
SGTC_2015 5119600 184 µM 0.405700935277235 0.346776146984504 no 1170 0.342481177494413 1727 2828786
SGTC_2995 9067767 71.4286 µM 0.404093216713227 0.347363485857485 no 1171 0.343072086458058 1641 11673567
SGTC_1571 st070080 73.4 µM 0.403032276687862 0.347751274111472 no 1172 0.343462240091233 1722 4315245
SGTC_1417 3966-0327 90.4 µM 0.402892813323404 0.347802261757999 no 1173 0.34351353923217 1649 651118
SGTC_2890 9046729 58.44 µM 0.400239858393789 0.34877270232205 no 1174 0.344489929943521 1563 903329
SGTC_1617 st002906 78 µM 0.39963219478761 0.348995122911301 no 1175 0.344713720028248 1609 5150859
SGTC_648 0375-0473 33.3 µM 0.398748026116195 0.349318844168579 no 1176 0.345039438334468 1650 1713139
SGTC_890 0929-0006 47.2 µM 0.397069591547703 0.349933671998424 no 1177 0.345658071511621 1581 1378169
SGTC_1608 st001473 40.5 µM 0.396938299441156 0.349981782267728 no 1178 0.345706480236406 1583 7292267
SGTC_1397 3532-0190 20.1 µM 0.393669817735441 0.351180248966223 no 1179 0.346912413800252 1656 5322280
SGTC_1401 3807-4679 7.6 µM 0.392046274697367 0.351776111229213 no 1180 0.34751201139351 1636 3291456
SGTC_1870 st057514 26.5 µM 0.390160790903563 0.35246856643142 no 1181 0.348208826479807 1615 5393161
SGTC_988 1497-1057 103 µM 0.389190283681852 0.352825181888283 no 1182 0.348567695245016 1745 3533044
SGTC_831 k061-1017 217 µM 0.388577362801726 0.353050467954594 no 1183 0.348794407586826 1734 1240153
SGTC_1269 0831-0796 3.05 µM 0.387298615141843 0.35352065204706 no 1184 0.349267575326298 1722 927758
SGTC_3008 9078912 71.4286 µM 0.385460187278164 0.354197017224428 no 1185 0.349948248921888 1617 16648731
SGTC_3119 9125183 49.47 µM 0.384711610411239 0.354472553706372 no 1186 0.350225546096978 1691 22695334
SGTC_114 0364-0001 490.298 µM 0.38470399847127 0.354475355903863 no 1187 0.350228366217106 1589 4003655
SGTC_108 0509-0257 621.132 µM 0.383800987683961 0.35480783878625 no 1188 0.350562977981678 1688 536624
SGTC_2860 9025725 38.96 µM 0.383176049146142 0.355038002004634 no 1189 0.350794617656013 1590 40546248
SGTC_1419 3993-2473 62.6 µM 0.382660950280402 0.355227751341305 no 1190 0.350985585875332 1685 704026
SGTC_1310 1188-0297 994 nM 0.382403041796113 0.355322771766055 no 1191 0.351081217245912 1660 1588352
SGTC_1552 6-methylflavone 10.6 µM 0.381839375697735 0.355530472827739 no 1192 0.351290255067145 1750 689013
SGTC_2717 st081029 62.2815 µM 0.380797416585164 0.355914529402018 no 1193 0.351676788184912 1743 5292846
SGTC_2332 7982454 138.89 µM 0.380084930043015 0.356177229638732 no 1194 0.351941185969594 1635 2981748
SGTC_1358 1509-0022 2.48 µM 0.379793889595734 0.356284558535281 no 1195 0.352049209247256 1674 3258434
SGTC_2640 pentamidine 10.38 µM 0.377312778034547 0.357199995822856 no 1196 0.352970588635936 1803 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3259 9138485 49.47 µM 0.37693630743584 0.357338971386091 no 1197 0.353110469341251 1757 17646153
SGTC_1792 st045773 43.6 µM 0.376070206233277 0.357658767784661 no 1198 0.353432351609646 1665 2919270
SGTC_489 paxilline 115 µM 0.375294414472734 0.357945303492101 no 1199 0.353720759850807 1631 105008 A toxic potassium channel blocker.
SGTC_520 3584-0023 682 µM 0.374603235676592 0.358200655163774 no 1200 0.353977783134577 1630 1340790
SGTC_2328 6201408 200 µM 0.373675962957247 0.358543329882352 no 1201 0.354322705351707 1642 2890418
SGTC_1309 pyrazolanthrone 13.4 µM 0.37365546764076 0.358550905238402 no 1202 0.354330330447073 1758 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3356 9151811 4.48 µM 0.372738399693016 0.358889923318173 no 1203 0.354671576926027 1643 1859254 YPR165W RHO1
SGTC_1615 st002656 86.5 µM 0.369543121830715 0.360072008148175 no 1204 0.355861468774956 1645 1584458
SGTC_822 1487-0950 154 µM 0.368722121208761 0.360375951940001 no 1205 0.356167429230517 1781 1958375
SGTC_157 1348-1695 65.819 µM 0.36733491255028 0.360889712866832 no 1206 0.356684607562185 1653 5380510
SGTC_2442 5158906 48.48 µM 0.367050958596702 0.360994907883907 no 1207 0.356790503641314 1764 1893835
SGTC_784 4579-0127 173 µM 0.366278757596539 0.361281034529481 no 1208 0.357078539437652 1806 1948547
SGTC_955 1216-0110 33 µM 0.365412121059921 0.36160224517347 no 1209 0.357401897307554 1603 3619719
SGTC_458 nppb 133 µM 0.361676234037706 0.362988030523576 no 1210 0.358796994461434 1827 4549 A chloride channel blocker.
SGTC_1001 4048-4355 44.4 µM 0.361470354024151 0.363064451779923 no 1211 0.358873931498153 1637 21824233
SGTC_821 1114-0266 29.2 µM 0.360057144635618 0.363589172488338 no 1212 0.359402200016503 1655 3123235
SGTC_264 promethazine 12.5 mM 0.35997401435892 0.363620046510102 no 1213 0.359433283134242 1684 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2087 5276107 200 µM 0.359371391017933 0.363843883208082 no 1214 0.35965863692865 1657 144405
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.359002993144236 0.363980742758862 no 1215 0.359796425066848 1676 4620898
SGTC_2045 5106652 78.05 µM 0.358705768857863 0.364091174019977 no 1216 0.359907606150575 1767 673349
SGTC_2248 tofa 1.1 µM 0.358326873882552 0.364231965723235 no 1217 0.360049354534537 1713 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_783 0848-0141 92.7 µM 0.357600425218098 0.364501954406588 no 1218 0.36032118002453 1664 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2955 9076254 12.21 µM 0.354188378462345 0.365770958043163 no 1219 0.361598856229847 1831 16459619
SGTC_785 1270-0111 65.3 µM 0.353316523758764 0.366095453407705 no 1220 0.361925579592294 1685 6741994
SGTC_1948 st076329 66.6 µM 0.353304067675283 0.366100090128641 no 1221 0.361930248179595 1661 24208413
SGTC_1964 st076914 61 µM 0.352690196033559 0.366328625295614 no 1222 0.362160355041782 1702 24208661
SGTC_3321 9137793 26.8275 µM 0.346152630748922 0.368765388927436 no 1223 0.36461400588835 1705 4904192
SGTC_32 0928-0142 34.1 µM 0.345850656043539 0.368878073195416 no 1224 0.364727476758316 1784 2244242
SGTC_1898 st060199 18.6 µM 0.345760783614635 0.368911611985612 no 1225 0.364761249765409 1674 688866
SGTC_945 3381-0768 11.3 µM 0.345394838454265 0.369048186508531 no 1226 0.364898778508684 1777 1126236 YIL048W NEO1
SGTC_1159 4092-0538 61.2 µM 0.344155443141849 0.369510864409524 no 1227 0.365364694503819 1742 717301
SGTC_2121 5257820 149.641 µM 0.342528511251629 0.370118500206245 no 1228 0.365976595658195 1839 791256
SGTC_708 3448-5400 146 µM 0.342392960504508 0.370169141128933 no 1229 0.366027592712688 1751 3462195
SGTC_1004 4084-0029 199 µM 0.341970551241821 0.370326965054498 no 1230 0.366186527177151 1834 716894 YLR208W SEC13
SGTC_2387 9077560 195.08 µM 0.341757470958507 0.370406586099115 no 1231 0.366266708850407 1667 5303272
SGTC_401 neomycin 50 µM 0.34122538412612 0.370605433561861 no 1232 0.36646695752229 1745 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1819 st053448 58.6 µM 0.341073719945776 0.370662118684948 no 1233 0.366524042368686 1727 2857616
SGTC_2919 7978188 46.38 µM 0.340475674811241 0.370885667914273 no 1234 0.366749169210183 1853 2980291
SGTC_1089 terbinafine 2.25 µM 0.339611025328063 0.371208950877656 no 1235 0.367074737064697 1804 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2720 fluspirilene 36.88 µM 0.338901554565646 0.371474282122016 no 1236 0.367341946651598 1776 3396 An atypical antipsychotic.
SGTC_3046 9092212 49.47 µM 0.337159645866447 0.372125988267944 no 1237 0.367998277993657 1714 25236637
SGTC_1940 st075990 51.1 µM 0.337111506075877 0.372144004181502 no 1238 0.368016422001328 1787 1084979
SGTC_811 0416-0114 265 µM 0.336036211216767 0.372546497158537 no 1239 0.368421780003817 1717 6612453
SGTC_2859 9028643 45.46 µM 0.334406073771022 0.373156938335739 no 1240 0.369036578382255 1816 17151580
SGTC_2627 acetyl isogambogic acid 100 µM 0.334140786609262 0.373256311184585 no 1241 0.369136661895478 1634 6857789 A caspase activator and apoptosis inducer.
SGTC_602 3130-1533 38.1 µM 0.333967083851856 0.373321382368338 no 1242 0.369202198641776 1816 720941
SGTC_2019 4016004 108 µM 0.333130919646264 0.373634670261413 no 1243 0.369517730288836 1682 45595336
SGTC_1625 st003711 30.1 µM 0.331674953158572 0.37418038037324 no 1244 0.3700673577712 1798 24207034 YER133W GLC7
SGTC_509 pifithrin 175 µM 0.330595739248757 0.374585042858766 no 1245 0.37047493250376 1780 4817 A p53 inhibitor.
SGTC_1722 st034304 3.6505 µM 0.330027760493492 0.374798067923203 no 1246 0.370689493174165 1699 4036148 YLR033W RSC58
SGTC_889 0919-1524 82.7 µM 0.329289371977554 0.37507506367478 no 1247 0.370968488266603 1716 3905452
SGTC_113 0099-0221 2.5 µM 0.329045690248858 0.375166491493905 no 1248 0.371060576651021 1825 89219
SGTC_696 1560-0013 611 µM 0.328131554059066 0.375509531989559 no 1249 0.371406098458193 1797 1650269
SGTC_1962 st076595 64.5 µM 0.325493509437223 0.376500040794495 no 1250 0.372403797071974 1733 279619
SGTC_1459 k035-0031 35.7 µM 0.325233011024689 0.376597894599338 no 1251 0.37250236319335 1636 3877128 YMR208W ERG12
SGTC_223 busulfan 5 mM 0.324588092547558 0.376840186330196 no 1252 0.372746420225116 1804 2478 A DNA alkylator.
SGTC_3160 9100216 49.47 µM 0.324400326102339 0.376910738100691 no 1253 0.372817486443621 1783 17191039
SGTC_1816 st051957 91.6 µM 0.323526558695027 0.37723910338925 no 1254 0.373148248580782 1751 674121
SGTC_611 3453-1652 23.7 µM 0.323028811157352 0.377426198614758 no 1255 0.373336711302166 1843 1560575
SGTC_1427 4048-4900 550 nM 0.322943787027022 0.377458160684349 no 1256 0.37336890711778 1856 24132586
SGTC_2532 xanthone 78.9 µM 0.320047416210042 0.378547457464616 no 1257 0.374466193221993 1813 7020 An insecticide.
SGTC_347 4534-1311 26.2 µM 0.319955374938576 0.378582089165262 no 1258 0.374501079657954 1716 2862016
SGTC_1366 1683-0113 21.9 µM 0.319434346254438 0.378778151219846 no 1259 0.374698584707406 1724 708623
SGTC_1630 st005209 31.3 µM 0.317523475130343 0.379497474899736 no 1260 0.375423214884961 1893 3367314
SGTC_2648 atorvastatin 78.68 µM 0.316417777935446 0.379913891621802 no 1261 0.375842712395915 1840 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1391 3442-0225 151 µM 0.316193591790729 0.379998339383836 no 1262 0.37592778572092 1759 5227075
SGTC_1698 5-fluorocytosine 1.055 µM 0.315471408072739 0.380270414701716 no 1263 0.376201878299349 1875 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_146 3448-8650 53.125 µM 0.314952354114947 0.380465999567746 no 1264 0.376398915004979 1783 2891488 YIL048W NEO1
SGTC_2593 nobiletin 86.24 µM 0.313718280357268 0.380931133864232 no 1265 0.37686750774717 1697 72344 An anti-infammatory.
SGTC_1476 4112-3294 3.34 µM 0.308498616895008 0.382900371473712 no 1266 0.37885147625774 1849 704369
SGTC_1653 st012112 65 µM 0.307662273700673 0.383216184127059 no 1267 0.379169664673088 1851 720429
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.307224072683249 0.383381684795182 no 1268 0.379336411816913 1707 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2452 5863136 48.41 µM 0.306691150048985 0.383582988798351 no 1269 0.379539233306522 1735 2184096
SGTC_666 0272-0154 136 µM 0.306431326703192 0.383681144799517 no 1270 0.379638129774867 1800 6870312
SGTC_1190 1486-1332 13 µM 0.304907987706956 0.384256781421914 no 1271 0.380218115981811 1734 4150046
SGTC_2938 9059746 27.26 µM 0.304848202955577 0.384279377993159 no 1272 0.380240883543157 1794 6471769
SGTC_748 act1.228 77.9 µM 0.304274254763185 0.384496330588767 no 1273 0.380459478787047 1693 4421505 YNR035C ARC35
SGTC_2435 5706476 10.6 µM 0.303452831690061 0.384806891700589 no 1274 0.380772394293278 1926 5725375
SGTC_1600 coumarin 106 71.1 µM 0.303446735504461 0.384809196804304 no 1275 0.380774716885375 1814 100336 A hepatotoxic, DNA x-linker.
SGTC_3257 9139206 32.98 µM 0.302804305816863 0.385052136603508 no 1276 0.381019500909034 1855 4910041
SGTC_400 oxethazaine 37.5 µM 0.301669739572756 0.385481291852054 no 1277 0.381451919250292 1767 4621 A local anesthetic.
SGTC_2343 7990716 14.84 µM 0.299193413487472 0.386418460815436 no 1278 0.382396237267277 1821 6456862
SGTC_2145 5634607 200 µM 0.299048339460434 0.386473384886731 no 1279 0.382451581306453 1721 308662
SGTC_3088 9117578 49.47 µM 0.297900214077731 0.386908137741326 no 1280 0.382889662277684 1830 678341
SGTC_549 1661-1316 519 µM 0.297380413736053 0.387105013722523 no 1281 0.383088047628961 1895 2857282
SGTC_1308 1187-1617 41.4 µM 0.296152197540589 0.387570319707734 no 1282 0.383556926487416 1770 2882570
SGTC_1280 0880-0253 10.1 µM 0.295823413634625 0.387694905930277 no 1283 0.383682470674679 1787 6836607
SGTC_2438 5259590 200 µM 0.294775194578526 0.388092185158408 no 1284 0.384082808378925 1896 1201127
SGTC_3004 9076122 71.4286 µM 0.293938297721932 0.388409456545788 no 1285 0.38440252636898 1868 44782551
SGTC_3332 9141069 11.198 µM 0.293731612217998 0.388487823431297 no 1286 0.384481498128022 1721 17332883
SGTC_2920 7982904 15.77 µM 0.293464257541044 0.388589200376473 no 1287 0.384583657876061 1758 6456808
SGTC_2693 st077581 40.7 µM 0.292131360743112 0.389094728256593 no 1288 0.385093094785632 1863 25238761
SGTC_661 1304-0007 33.6 µM 0.291620940587105 0.389288365127342 no 1289 0.385288231387373 1769 3117130
SGTC_2704 st078022 71.1 µM 0.290815237300316 0.389594078790881 no 1290 0.385596315549274 1917 54697681
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.29006393808481 0.389879211106241 no 1291 0.385883661778821 1845 5393153
SGTC_2734 clemastine 41.6 µM 0.289681792000278 0.390024265550699 no 1292 0.386029843611779 1853 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1320 1313-0481 95.3 µM 0.288810573640622 0.390355018553856 no 1293 0.386363170083765 1924 6813365 YLR208W SEC13
SGTC_1857 st056007 79.3 µM 0.288798691925048 0.390359529927507 no 1294 0.386367716585651 1925 619834
SGTC_510 ag-490 170 µM 0.288659550986878 0.390412361508203 no 1295 0.386420959598207 1899 5328779
SGTC_414 piperonyl butoxide 100 µM 0.287101020868033 0.391004270844295 no 1296 0.38701748526465 1757 5794 A potent inhibitor of cytochrome P450.
SGTC_1664 st014217 9.02 µM 0.287078115720986 0.391012971805896 no 1297 0.387026254178092 1896 3982782
SGTC_644 1498-1197 63.3 µM 0.285751790178043 0.391516895034358 no 1298 0.387534117461895 1861 6741615
SGTC_484 loperamide 105 µM 0.285721314069839 0.391528476249762 no 1299 0.387545789333574 1821 3955 An opioid-receptor agonist.
SGTC_2090 5301565 104.445 µM 0.2851774833176 0.391735153343276 no 1300 0.38775408506531 1815 2056344
SGTC_96 0929-0093 37.281 µM 0.284438192051214 0.392016162125063 no 1301 0.388037297048034 1760 6991579
SGTC_1933 st074711 15.9 µM 0.2843630598733 0.392044723445709 no 1302 0.388066082454625 1868 17250958
SGTC_1877 wortmannin 25 µM 0.281717100339035 0.393050948647248 no 1303 0.389080220593358 1919 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1068 loratadine 26.9 µM 0.281229698201897 0.393236379744843 no 1304 0.389267113796288 1780 3957 A H1 histamine antagonist.
SGTC_2397 5161689 200 µM 0.280169201098034 0.393639927232887 no 1305 0.389673847376161 1873 2259942
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.27762270610294 0.394609402466862 no 1306 0.390651000063905 1907 6708630 An antioxidant.
SGTC_543 3844-1095 191 µM 0.277396964477603 0.394695376083871 no 1307 0.390737656102657 1884 4230703
SGTC_95 0471-0001 561.058 µM 0.275271334503849 0.395505172467495 no 1308 0.391553892901464 1724 4015405
SGTC_3050 9093513 49.47 µM 0.273904050946551 0.396026302133919 no 1309 0.392079179197556 1802 25236664
SGTC_195 4234-0266 16.654 µM 0.27382516373979 0.396056375069622 no 1310 0.392109492287322 1833 2303354
SGTC_3127 9126946 49.47 µM 0.272324945879029 0.396628397207135 no 1311 0.392686088377456 1747 27243249
SGTC_3110 9122132 49.47 µM 0.272305184514148 0.396635933559232 no 1312 0.392693685066363 1939 918317
SGTC_2518 prenyletin 46.28 µM 0.271160673926424 0.397072479058956 no 1313 0.393133728930932 1942 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1260 0700-1617 7.75 µM 0.269633686201899 0.397655111861143 no 1314 0.393721041007683 1847 2853078
SGTC_1200 1643-0193 18.4 µM 0.268958070377656 0.39791297073768 no 1315 0.393980974531652 1943 5403974
SGTC_2990 9074105 71.4286 µM 0.268896529535944 0.397936460937671 no 1316 0.394004653839202 1856 6502001
SGTC_2956 9076196 2.52 µM 0.268365987324397 0.39813898475835 no 1317 0.394208808858475 1920 16423868
SGTC_2028 5153890 36.43 µM 0.267741047947668 0.398377577999779 no 1318 0.39444932561368 1820 2830968 YPR165W RHO1
SGTC_1432 4049-0298 68.4 µM 0.267689453121512 0.39839727789248 no 1319 0.39446918441178 1964 741646
SGTC_1515 3460-0031 42.1 µM 0.267102881096454 0.398621260518961 no 1320 0.394694974682743 1895 2876596
SGTC_2210 7115885 190.385 µM 0.267024067354582 0.398651358106254 no 1321 0.394725315302107 1865 2927039
SGTC_633 0437-0093 97.7 µM 0.266480229156438 0.398859056807219 no 1322 0.394934691971084 1826 2831118
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.263707784694166 0.399918332517597 no 1323 0.39600254825 1795 6708561
SGTC_2682 pyrogallin 40.03 µM 0.263451725337775 0.400016203131167 no 1324 0.396101213578112 1892 822798 An ATP competetive kinase inhibitor.
SGTC_2870 9038528 12.99 µM 0.263317653806447 0.400067450251298 no 1325 0.396152876957018 1837 6463316
SGTC_596 1155-0152 116 µM 0.262704998241902 0.400301651856375 no 1326 0.39638898201491 1804 280313
SGTC_1924 st058459 75.1 µM 0.261759516089049 0.400663154375689 no 1327 0.396753426255905 1887 688683
SGTC_1504 k297-0033 30 µM 0.260792829322294 0.401032852402931 no 1328 0.397126137260075 1778 4388117
SGTC_2106 5357045 167.29 µM 0.260400851834738 0.401182784877091 no 1329 0.39727729297235 1917 668842
SGTC_286 k060-0067 22.9 µM 0.259125479513626 0.401670718921544 no 1330 0.397769213111244 1839 5985051
SGTC_2126 5251174 33.877 µM 0.257779849592096 0.40218569846434 no 1331 0.398288408369222 1998 790722
SGTC_1014 4130-3005 69.3 µM 0.257610411903838 0.402250555202787 no 1332 0.398353796667288 1801 743608
SGTC_1289 0976-0073 69.1 µM 0.256724111115776 0.402589853992903 no 1333 0.398695878614105 1908 3391136
SGTC_530 4358-1714 28 µM 0.254639113235085 0.403388333896002 no 1334 0.399500923368889 1913 1564641
SGTC_2079 5212404 121 µM 0.253651880276414 0.403766549711089 no 1335 0.399882256174984 1992 758462
SGTC_1737 st035557 69.7 µM 0.253229618751952 0.403928348539562 no 1336 0.400045389889894 1780 5716916
SGTC_409 arachidonic acid 100 µM 0.253143295085688 0.403961427383406 no 1337 0.400078741750747 1867 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_816 0325-0417 81.3 µM 0.252254787164937 0.404301939528878 no 1338 0.400422066433238 1841 68101
SGTC_760 0568-0725 82.9 µM 0.250225148992311 0.405080050519371 no 1339 0.401206618831035 1990 3916171
SGTC_1851 st056236 18.9 µM 0.250040713773477 0.4051507768831 no 1340 0.40127793167908 1973 5393171
SGTC_3320 9137005 35.139 µM 0.249894357501136 0.405206903113349 no 1341 0.401334523442513 1839 4908713
SGTC_2112 5488546 200 µM 0.249539811427309 0.405342876220599 no 1342 0.401471624795723 1864 600757
SGTC_2288 7946289 167.31 µM 0.249119908189763 0.405503929441884 no 1343 0.401634015156046 1965 1246052
SGTC_730 1436-0052 41.2 µM 0.247402982129703 0.406162619889835 no 1344 0.402298183252989 1903 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1960 st011366 51.8 µM 0.247397261362379 0.406164815079913 no 1345 0.402300396722061 1881 3972846
SGTC_399 oxolinic acid 75 µM 0.245143250707276 0.407029959710761 no 1346 0.403172757583498 1867 4628 A DNA gyrase inhibitor.
SGTC_1829 berberine 14.4 µM 0.244516418218676 0.407270634243993 no 1347 0.403415443957822 1968 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2958 9077254 16.72 µM 0.242851782758395 0.407909946591122 no 1348 0.404060109616296 1871 16457351
SGTC_3331 9141060 1.957 µM 0.241887758597104 0.408280297603505 no 1349 0.404433567872825 1821 4906567 YPR165W RHO1
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.241670829208289 0.408363647089285 no 1350 0.404517617275655 1766 641818 YHR062C RPP1
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.241190675264294 0.40854814851523 no 1351 0.404703668832534 1958 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_89 0302-0250 142.109 µM 0.239630900130328 0.409147639177826 no 1352 0.405308203878088 1979 4203518 YLR208W SEC13
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.239316865824612 0.409268362219865 no 1353 0.405429944146325 1962 16725076
SGTC_1775 st081588 35.1725 µM 0.23723636553619 0.410068378057956 no 1354 0.40623671291156 1905 1426443 YGL099W LSG1
SGTC_729 4092-0585 94.1 µM 0.237041030252712 0.410143509715188 no 1355 0.40631247981512 1816 2169061
SGTC_2238 6671620 73.2395 µM 0.236117705959039 0.410498691817211 no 1356 0.406670667480768 1834 729941
SGTC_3017 9080681 49.47 µM 0.235908440659333 0.410579201690072 no 1357 0.406751859195226 1851 16451914
SGTC_2360 9040895 200 µM 0.235803848047882 0.410619442635187 no 1358 0.406792441020736 1851 4914414
SGTC_2583 asiatic acid 100 µM 0.235579430666364 0.410705788118443 no 1359 0.406879518110781 1911 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1523 st012844 44.7 µM 0.235123236467638 0.410881323992757 no 1360 0.407056542041768 1885 4274103
SGTC_2763 lisinopril 49.32 µM 0.235110671105733 0.410886159185953 no 1361 0.40706141823797 2023 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.234177775349397 0.411245178358713 no 1362 0.407423484030215 1958 688751
SGTC_1135 dihydrocapsaicin 536.708 nM 0.233569060108917 0.411479478761376 no 1363 0.407659774921778 1754 107982 A Capsaicinoid.
SGTC_285 1486-1325 46 µM 0.233153496517991 0.411639451359387 no 1364 0.407821107569152 1975 22310230
SGTC_2661 dactinomycin 12.96 µM 0.233042315949362 0.411682253183914 no 1365 0.407864273423468 1919 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3329 9141233 27.5565 µM 0.232994050755996 0.411700834440852 no 1366 0.407883012732343 1979 4909101 YNL103W MET4
SGTC_2522 biochanin a 4.94 µM 0.232576760516631 0.411861492151385 no 1367 0.40804503745535 1945 5280373 A possible chelator.
SGTC_2280 7785178 200 µM 0.232556069545722 0.411869458607896 no 1368 0.408053071718704 1886 2954328
SGTC_172 1112-0046 2.638 µM 0.231476402656753 0.412285203263261 no 1369 0.408472357813335 1882 2802135 YIL048W NEO1
SGTC_3185 9108267 49.47 µM 0.231335789003867 0.412339356270061 no 1370 0.408526972517554 1825 4910486
SGTC_3117 9124945 49.47 µM 0.230379799164103 0.412707570432885 no 1371 0.408898328474508 1806 17592065
SGTC_2253 7938677 135.83 µM 0.229934831690663 0.412878982707728 no 1372 0.409071204798766 2024 2301972
SGTC_1104 tacrolimus 29.8 µM 0.229060072314834 0.413216009661621 no 1373 0.409411113054745 1908 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1154 4088-0362 150 µM 0.228532218957101 0.413419411759092 no 1374 0.409616255815609 1876 6618304
SGTC_1487 3970-0795 2.82 µM 0.227234030970446 0.413919752011835 no 1375 0.410120883427775 1950 3765103
SGTC_789 1309-1135 70.6 µM 0.226022110311208 0.414386969763904 no 1376 0.410592111859433 1866 3092424
SGTC_1513 0337-0559 19 µM 0.225966723468583 0.414408325312917 no 1377 0.410613650892837 1840 775073
SGTC_351 caspofungin 25 nM 0.225376746279038 0.414635818977641 no 1378 0.410843100048599 1933 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2080 5212524 12.4 µM 0.224228712892102 0.415078579663407 no 1379 0.411289671288837 2058 260183
SGTC_976 1348-1067 47.6 µM 0.223783732055234 0.415250223940959 no 1380 0.411462794454792 1905 5310671 YGL099W LSG1
SGTC_3100 9120536 49.47 µM 0.221446595757544 0.416152001937582 no 1381 0.412372357350173 2028 16421196
SGTC_715 0868-0130 184 µM 0.221112304493077 0.416281023566711 no 1382 0.412502494881837 2057 2876258
SGTC_753 1322-0200 289 µM 0.221068567984976 0.416297904590315 no 1383 0.412519521947149 1939 5403907
SGTC_2307 7538926 6.34 µM 0.220896295460456 0.416364398289749 no 1384 0.412586590985756 1892 96582
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.220726085908199 0.416430098074534 no 1385 0.412652859375869 1889 6857784
SGTC_179 1273-0063 6.77 µM 0.218650719175175 0.41723136345214 no 1386 0.413461070207517 1871 3108139
SGTC_1634 st006576 41 µM 0.217216223248646 0.417785400215162 no 1387 0.414019921091132 2048 3915356
SGTC_712 r015-0009 80.6 µM 0.215300807427185 0.418525434087791 no 1388 0.414766400076376 1973 6813872 YLR060W FRS1
SGTC_1157 4092-0394 27.6 µM 0.215132375496694 0.418590522740652 no 1389 0.41483205640988 2001 3659885
SGTC_1578 josamycin 24.2 µM 0.214830321325192 0.418707253809306 no 1390 0.41494980589382 1853 5282165 A P450 substrate.
SGTC_2000 st075254 36.4 µM 0.213906209787346 0.419064427957183 no 1391 0.4153100988013 1920 17234175
SGTC_897 1000-0139 31.4 µM 0.212302543367439 0.419684411952398 no 1392 0.415935505668844 2041 6151020
SGTC_1662 st014054 52 µM 0.211720075239598 0.419909645960527 no 1393 0.416162712675028 2032 2838777
SGTC_1028 k015-0029 4.8 µM 0.210684367896922 0.420310207335696 no 1394 0.416566786715653 1884 4588309
SGTC_2002 4023503 131 µM 0.208577316167635 0.421125367133282 no 1395 0.417389110083823 2114 4736863 YCR052W RSC6
SGTC_3056 9094900 49.47 µM 0.208487820627974 0.421159997984842 no 1396 0.417424045717769 1850 25236784
SGTC_3305 9127027 53.8275 µM 0.207588373154461 0.42150807856437 no 1397 0.417775191744018 1938 41905295
SGTC_2035 5154463 94.595 µM 0.206889023226294 0.42177876504469 no 1398 0.418048264629076 2038 2769623
SGTC_487 nimodipine 119 µM 0.206516011336165 0.421923156068209 no 1399 0.418193929531097 2053 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2364 9055074 200 µM 0.206316630146387 0.422000339828244 no 1400 0.418271794498198 1888 6470630
SGTC_1943 st076331 65.2 µM 0.20581913641053 0.422192940949312 no 1401 0.418466096262364 2083 24208415
SGTC_1971 st069429 63.5 µM 0.205555476468832 0.422295022546205 no 1402 0.418569079682241 2048 1246522 YGL099W LSG1
SGTC_1627 st003713 25.6 µM 0.20523135794071 0.422420519132406 no 1403 0.418695685379548 1909 16195070 YER133W GLC7
SGTC_1259 0671-0132 43 µM 0.203633355088152 0.423039370345122 no 1404 0.419320012824369 1906 X1259
SGTC_623 k072-0108 16.9 µM 0.203397580645198 0.423130693745846 no 1405 0.419412145327246 1966 5382803
SGTC_2405 ticlatone 3.52 µM 0.202456178135414 0.42349537183964 no 1406 0.419780056881351 1812 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1524 corynanthine 62.1 µM 0.202244206752618 0.423577493822774 no 1407 0.419862907560698 1971 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2939 9044578 71.43 µM 0.201875185566217 0.423720467981004 no 1408 0.42000715086097 1923 2653634
SGTC_199 4063-0024 41.6 µM 0.200674037530678 0.424185912143012 no 1409 0.420476730894328 2034 306215
SGTC_904 1141-0088 396 µM 0.200481695120928 0.424260454555087 no 1410 0.420551936283498 1863 1378119
SGTC_932 2857-0803 154 µM 0.200015577368643 0.424441109993266 no 1411 0.420734199154187 2054 674898
SGTC_3208 9114115 49.47 µM 0.199897401200042 0.424486914607949 no 1412 0.420780411483595 1827 650895
SGTC_920 mycophenolic acid 780.421 nM 0.199028360891054 0.424823782473524 no 1413 0.421120279795888 1904 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1426 4048-4480 71.7 µM 0.198555909310292 0.425006942897774 no 1414 0.421305073034045 2032 14224343
SGTC_2948 9070189 9.45 µM 0.198466010972855 0.425041796595078 no 1415 0.421340237553832 2070 6473636 YDL196W YDL196W
SGTC_739 1486-1183 203 µM 0.197991400158132 0.425225813504501 no 1416 0.421525896112136 2075 4346692
SGTC_2402 5553605 200 µM 0.197690619935337 0.425342440958753 no 1417 0.421643564544228 2015 6758546
SGTC_1199 1638-0010 4.46 µM 0.195372420742559 0.426241540577398 no 1418 0.422550702813684 1900 3111136
SGTC_574 1315-0397 40 µM 0.195353047480269 0.42624905600303 no 1419 0.422558285534264 2033 6794277
SGTC_2787 5284540 71.43 µM 0.194453811447791 0.426597924023294 no 1420 0.422910279245987 1942 736958
SGTC_1439 4092-1168 46 µM 0.192551457114932 0.427336151230596 no 1421 0.423655132487375 2034 2886240
SGTC_1053 3366-3204 134 µM 0.19147957131187 0.427752219274301 no 1422 0.42407494207715 1897 3632071 YPR165W RHO1
SGTC_2083 5306046 65.942 µM 0.191312606301088 0.427817036413073 no 1423 0.424140342551301 1945 539837
SGTC_129 0088-0017 176.636 µM 0.191256620273045 0.427838771068501 no 1424 0.424162272839967 2075 182446
SGTC_207 4185-0010 4.486 µM 0.19037162620563 0.42818236871021 no 1425 0.424508965042544 2061 3761753
SGTC_2464 5717415 7.67 µM 0.190355600504335 0.428188591167873 no 1426 0.424515243573812 1879 5285744
SGTC_200 k038-0079 37.545 µM 0.189882357340814 0.428372350017673 no 1427 0.424700658876576 2015 3436683
SGTC_93 0109-0045 59.227 µM 0.189668324149972 0.428455463543701 no 1428 0.424784521936148 2084 88733
SGTC_3254 9136651 49.47 µM 0.189599114563271 0.428482339740446 no 1429 0.424811640550865 1967 16454030
SGTC_1799 st045822 46.1415 µM 0.187496009055225 0.429299197467315 no 1430 0.425635876258715 2088 3674992
SGTC_672 1441-0018 53.7 µM 0.186934310449184 0.429517415677578 no 1431 0.425856068747746 1947 251141
SGTC_3246 9135460 32.98 µM 0.186903111094964 0.429529537164367 no 1432 0.425868299941591 2034 41446951
SGTC_938 3126-1755 342 µM 0.185305137439488 0.430150466064552 no 1433 0.426494854360159 2105 1777771
SGTC_231 b-estradiol 524 µM 0.185221683079483 0.430182898909181 no 1434 0.426527581349401 1945 450 A steroid.
SGTC_1425 4048-4433 7.33 µM 0.184520705831021 0.430455338075994 no 1435 0.426802492566445 2058 23734946
SGTC_1999 st074831 12.5 µM 0.184393746528373 0.430504685143346 no 1436 0.426852287628098 1948 17112523
SGTC_956 1185-0240 191 µM 0.183579004892606 0.430821388092164 no 1437 0.427171867425098 1986 1416193
SGTC_3144 9087057 49.47 µM 0.182569971645361 0.431213676914333 no 1438 0.427567723723339 2148 17249618
SGTC_1778 st046819 58.9 µM 0.181891177526794 0.431477614597867 no 1439 0.42783406415957 1947 671715
SGTC_2388 9080168 200 µM 0.180391300411919 0.432060924938071 no 1440 0.428422691781113 1898 15943073
SGTC_2386 9075165 157.42 µM 0.179841514884752 0.432274776679502 no 1441 0.428638495383536 2018 16452277
SGTC_1692 fluoroquinolonic acid 71 µM 0.179486946640403 0.432412704692516 no 1442 0.428777682985837 2043 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1545 lovastatin 49.4 µM 0.178653389560965 0.432736993081763 no 1443 0.429104934999382 1996 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2856 9022925 19.48 µM 0.177562741901047 0.433161368797256 no 1444 0.429533193573992 1997 4944862
SGTC_2730 imipramine 71.33 µM 0.176447170094415 0.433595522352857 no 1445 0.4299713247801 2100 3696 A tricyclic antidepressant.
SGTC_55 0767-0285 6.563 µM 0.175352731771504 0.434021529145995 no 1446 0.430401239810567 2102 3116166
SGTC_657 3534-0529 86.7 µM 0.175210804100038 0.434076779685511 no 1447 0.430456997603764 2086 1049549
SGTC_443 clozapine 122 µM 0.174993924186574 0.434161210615179 no 1448 0.430542203859231 2124 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3354 9151612 71.43 µM 0.174331521398685 0.434419101315612 no 1449 0.430802464014395 2089 27261949
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.174084266745645 0.43451537116699 no 1450 0.430899618860632 2056 2333 A French combination drug.
SGTC_2610 ononetin 44.17 µM 0.173545269443626 0.434725245947706 no 1451 0.431111423901628 1961 259632
SGTC_335 4077-0256 27.6 µM 0.171234443549396 0.435625243150293 no 1452 0.432019712701157 2079 3121989
SGTC_3299 9121982 43.1275 µM 0.170552325507352 0.435890971581064 no 1453 0.432287893640252 1981 17594604 YPL160W CDC60
SGTC_288 1315-0019 35.1 µM 0.169764370629598 0.436197966222938 no 1454 0.432597724128696 2016 6811474
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.168225699618152 0.436797557599352 no 1455 0.433202861839482 2114 688662
SGTC_143 4032-1194 15.74 µM 0.16798992157353 0.436889448768889 no 1456 0.433295603911427 1944 1806963
SGTC_318 1488-0629 67.2 µM 0.167764846783466 0.436977171672781 no 1457 0.433384139340813 1982 3662576
SGTC_2228 7354201 200 µM 0.167717266559102 0.436995716463101 no 1458 0.433402855928187 2063 753451
SGTC_1389 3405-0187 19 µM 0.167695083188405 0.437004362664655 no 1459 0.433411582230565 1946 799890
SGTC_542 3381-0244 89.3 µM 0.167543791054847 0.437063331163774 no 1460 0.433471097086152 2110 1112843
SGTC_1972 st070201 17.4 µM 0.166802389718534 0.437352324238579 no 1461 0.433762769154215 2128 2829099
SGTC_1380 2291-0730 164 µM 0.166586844174562 0.437436348668281 no 1462 0.4338475729366 1974 2999191
SGTC_1955 wogonin 32.4 µM 0.166536728917389 0.437455885110548 no 1463 0.433867290613707 2083 5281703 A flavanone.
SGTC_606 k015-0008 38.6 µM 0.166067227783262 0.437638918245629 no 1464 0.434052022220596 2091 1970475
SGTC_281 1672-3440 14.9 µM 0.164097168929712 0.438407082824507 no 1465 0.434827325235233 2095 6833000
SGTC_499 genistein 192 µM 0.162501593440741 0.439029399254253 no 1466 0.435455436785102 2138 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3156 9099931 49.47 µM 0.161939550046279 0.439248646948877 no 1467 0.435676728710285 2015 18111053
SGTC_66 0109-0187 42.4 µM 0.161685265535849 0.439347847005877 no 1468 0.435776854129917 2072 759417
SGTC_1281 0884-0031 11.8 µM 0.159808690691815 0.440080043305962 no 1469 0.43651588894511 2009 1548255
SGTC_3073 9114972 49.47 µM 0.159722281545001 0.440113763121083 no 1470 0.436549924050293 2138 41905075
SGTC_42 0133-0086 60.653 µM 0.159600200180537 0.440161404200297 no 1471 0.436598010640797 2059 162923 Model of phenazepam hydroxylation.
SGTC_144 4161-2749 112.381 µM 0.159518968224202 0.440193104670632 no 1472 0.436630007589869 2048 797501 YMR168C CEP3
SGTC_3096 9117468 49.47 µM 0.159346386779015 0.440260455213142 no 1473 0.436697988120322 2122 41316311
SGTC_1911 st060208 74.3 µM 0.158534974985854 0.440577134780309 no 1474 0.437017631538101 2091 688783
SGTC_2104 5389443 200 µM 0.158269902880399 0.440680595947092 no 1475 0.437122061610383 2093 2244536
SGTC_859 0439-0102 54.6 µM 0.158233951155195 0.440694628695416 no 1476 0.4371362257969 2144 610143
SGTC_2903 5923464 63.88 µM 0.157697476262461 0.440904035471755 no 1477 0.437347594630599 2147 2876576
SGTC_1710 st031758 61.5 µM 0.157627081392129 0.440931514523814 no 1478 0.437375331239606 2126 5394341
SGTC_1003 4049-0218 100 µM 0.156866101744589 0.441228585536884 no 1479 0.437675187974765 2072 295161
SGTC_1469 k284-2957 126 µM 0.156307662229158 0.441446610040487 no 1480 0.437895258495266 2090 23884841
SGTC_2597 laccaic acid a 100 µM 0.155315783008072 0.441833900653151 no 1481 0.438286186779655 2022 5491415 A textile dye.
SGTC_3016 9080866 49.47 µM 0.155254514702542 0.44185782539289 no 1482 0.438310336369553 2079 17066299
SGTC_416 estradiol valerate 100 µM 0.155112038590377 0.441913461893893 no 1483 0.438366495815442 2019 13791 A steroid.
SGTC_2997 9067075 71.4286 µM 0.155001066256215 0.441956797056563 no 1484 0.438410238357347 2057 27209819
SGTC_901 1112-0062 60.1 µM 0.153684401589976 0.442471013016489 no 1485 0.438929292192518 2052 1908457
SGTC_192 3455-0609 60.9 µM 0.151083808152958 0.443486944123513 no 1486 0.439954802549397 2070 3769639
SGTC_843 0310-0051 143 µM 0.151019845384071 0.443511936116545 no 1487 0.439980030545073 2029 2065037
SGTC_2222 6885208 172.143 µM 0.150742227224201 0.443620411683127 no 1488 0.440089530656186 2076 609514
SGTC_2714 st079313 56.9 µM 0.14932159140529 0.444175571997341 no 1489 0.440649939394798 2045 2939799
SGTC_3128 9127691 49.47 µM 0.148679839182115 0.444426393838014 no 1490 0.440903135201119 2068 41316314
SGTC_1990 st072050 59.8 µM 0.148597321654549 0.444458646528582 no 1491 0.440935693278108 1975 17233948
SGTC_276 colchicine 750 µM 0.146686933942618 0.445205440499059 no 1492 0.441689566120749 2056 2833 A microtubule depolymerizer.
SGTC_2545 solidagenone 89.61 µM 0.146540284039167 0.445262775815517 no 1493 0.441747445537672 2126 6708572 An anti ulcer agent
SGTC_3058 9093861 49.47 µM 0.146539105971201 0.445263236406204 no 1494 0.441747910499626 2102 17217477
SGTC_2027 5150920 200 µM 0.146363338555001 0.44533195723741 no 1495 0.441817283594299 2101 786715
SGTC_2061 5245884 80.95 µM 0.146104629266372 0.445433109333198 no 1496 0.441919396004639 2072 573863
SGTC_1680 diphenhydramine 100 µM 0.144259651377555 0.446154575225413 no 1497 0.442647719253669 2000 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1243 0416-0003 5.65 µM 0.143672545734402 0.446384196353314 no 1498 0.44287952578542 2024 2141977
SGTC_818 4072-2707 53.5 µM 0.143521097154969 0.446443431873473 no 1499 0.442939325303374 2114 882871
SGTC_1379 2144-0755 36.5 µM 0.142512587960422 0.446837916741971 no 1500 0.443337568550015 2157 5392327
SGTC_273 hydroxyurea 18.1 mM 0.141910104924863 0.447073606990015 no 1501 0.44357550626238 2072 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2645 abamectin 100 µM 0.141690254722405 0.44715961664183 no 1502 0.443662336440536 2121 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_943 3253-1379 105 µM 0.141485397210259 0.447239763100027 no 1503 0.443743247666962 2106 668464
SGTC_2567 aureobasidin a 60 nM 0.141455390093987 0.447251502972984 no 1504 0.44375509957764 2045 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3001 9076041 71.4286 µM 0.141177409262901 0.447360261358991 no 1505 0.44386489605647 2107 16004211
SGTC_1305 1181-0477 144 µM 0.140461982095381 0.447640186267261 no 1506 0.444147494271486 2155 6252086
SGTC_3251 9135047 49.47 µM 0.14027484452028 0.447713411821972 no 1507 0.44422141947818 2133 17682963
SGTC_2269 7935389 174.42 µM 0.139721724406764 0.447929854056143 no 1508 0.444439930591664 2017 97605
SGTC_964 1287-0107 19.4 µM 0.137703231296337 0.448719844571145 no 1509 0.445237482763393 2144 51516812 YPR165W RHO1
SGTC_707 0865-0008 204 µM 0.1366861760247 0.449117973223199 no 1510 0.445639428450764 2091 723043
SGTC_3070 9117005 49.47 µM 0.136156040981037 0.44932551615824 no 1511 0.445848962838815 2177 8779016
SGTC_2804 7954240 19.48 µM 0.134838970074592 0.449841197049398 no 1512 0.446369596760104 2141 828705
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.134239601217026 0.450075899732842 no 1513 0.446606556023019 2044 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1777 st045864 34.765 µM 0.133768918386428 0.450260223395204 no 1514 0.446792652895576 2171 4691462
SGTC_3288 9119690 36.221 µM 0.133431964508197 0.450392184180223 no 1515 0.446925883698467 2045 17595618 YKL019W RAM2
SGTC_2070 5230947 200 µM 0.13312031369068 0.450514240444798 no 1516 0.44704911506099 2181 2835538
SGTC_2614 arthonioic acid 13.39 µM 0.132799158953531 0.450640023761718 no 1517 0.447176109763238 2170 6710684
SGTC_848 0368-0089 85.6 µM 0.132718464745059 0.450671629198179 no 1518 0.447208019647779 2164 762535
SGTC_1109 tnp00067 928.257 nM 0.13241866921017 0.450789052615068 no 1519 0.447326574405293 2032 676295
SGTC_198 3454-2873 16.191 µM 0.131985872687399 0.450958577232511 no 1520 0.447497732974503 2071 710957
SGTC_2323 6148992 148.28 µM 0.131433942855103 0.451174778851759 no 1521 0.447716019519704 2069 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2157 5649910 96.377 µM 0.131115199711974 0.451299643324808 no 1522 0.447842088666509 2041 2858091
SGTC_262 fenpropimorph 62.5 µM 0.131021494587429 0.451336352297451 no 1523 0.447879151878582 2161 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1677 st019204 53.9 µM 0.130569181742721 0.451513551653653 no 1524 0.448058061688365 1986 3945625
SGTC_1646 st011709 75.6 µM 0.129459057810293 0.451948497821087 no 1525 0.448497209703056 2184 5757843
SGTC_1946 st076057 65.1 µM 0.129281131884137 0.452018214513345 no 1526 0.448567600355268 2119 953009
SGTC_372 0155-0182 15.9 µM 0.128584236376095 0.45229129321578 no 1527 0.448843320149348 2107 771486
SGTC_3166 9102297 49.47 µM 0.128310221130638 0.452398672356617 no 1528 0.448951738337643 2044 25237072
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.127765934550956 0.452611973820017 no 1529 0.449167104678482 2153 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.127661338265533 0.452652965818159 no 1530 0.449208493636001 2152 368090
SGTC_381 3461-2219 42.7 µM 0.127093184843196 0.452875637826075 no 1531 0.449433322714449 2164 2883159
SGTC_3169 9102970 49.47 µM 0.126644995252223 0.453051303790669 no 1532 0.449610691289529 2195 17027839
SGTC_2623 humulene 100 µM 0.126398169464247 0.453148050012354 no 1533 0.449708375544078 2073 6187145 An anti-inflammatory.
SGTC_710 3448-4187 58 µM 0.12547009717058 0.453511843519311 no 1534 0.450075698467286 2121 3946412
SGTC_2149 5554786 194.827 µM 0.125454505615134 0.45351795556114 no 1535 0.450081869835231 2061 745063 YPR165W RHO1
SGTC_2827 7993847 71.43 µM 0.125321324011702 0.453570164497404 no 1536 0.450134585572858 2091 2985692
SGTC_1172 0370-0043 85 µM 0.124627755085401 0.453842065568349 no 1537 0.450409127160619 2123 376585
SGTC_202 3594-0513 34.79 µM 0.124054620031244 0.454066769064447 no 1538 0.450636014246207 2196 708429
SGTC_1522 st012842 45.6 µM 0.121158506820791 0.455202443441241 no 1539 0.451782744349286 2059 3491067 YOR116C RPO31
SGTC_2762 leflunomide 42.06 µM 0.116432812534443 0.45705634720492 no 1540 0.453654765795127 2097 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1954 st077032 68.9 µM 0.116380705411007 0.45707679426827 no 1541 0.453675413163373 1971 698907
SGTC_100 0086-0128 49.5915 µM 0.115298517151188 0.457501475285503 no 1542 0.45410425683366 2016 93297
SGTC_2911 7942208 15.64 µM 0.115145592499828 0.457561491131333 no 1543 0.454164861308355 2077 1243384
SGTC_138 0850-0259 40.9225 µM 0.113780341544972 0.458097331652233 no 1544 0.454705961276172 2209 6813004
SGTC_465 cgp-37157 41 µM 0.11303607886506 0.45838947573029 no 1545 0.45500097585352 2205 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_819 1013-0258 27.7 µM 0.11218124292411 0.458725050656306 no 1546 0.455339850630627 2126 5753198
SGTC_3240 9133527 49.47 µM 0.109267402051659 0.459869129430295 no 1547 0.456495200572321 2120 17617455
SGTC_169 k015-0017 16.025 µM 0.109064650010493 0.459948749654402 no 1548 0.456575606396599 2185 1840002
SGTC_441 propafenone 146 µM 0.107939019571758 0.460390811061039 no 1549 0.457022032389953 2202 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_735 3076-0345 636 µM 0.106828403410117 0.460827023998142 no 1550 0.457462556873951 2207 2888990
SGTC_1171 0368-0077 21.4 µM 0.106103967926051 0.461111583498842 no 1551 0.457749931485028 2129 3239779
SGTC_2472 5377652 49.4 µM 0.105008809280689 0.461541801452065 no 1552 0.458184409287186 2066 1610903
SGTC_1253 0550-0034 176 µM 0.104877099942128 0.461593544689059 no 1553 0.458236665169688 2125 5969915
SGTC_340 k038-0059 454 µM 0.103611453802333 0.46209079854265 no 1554 0.458738848884925 2197 23733424
SGTC_1856 st057054 55.7 µM 0.0999850301171179 0.463515892846893 no 1555 0.460178105060564 2228 1266018
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0979406868340358 0.464319476491585 no 1556 0.46098969592741 2232 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2843 9000894 45.46 µM 0.0959561785282701 0.465099679675316 no 1557 0.461777688183472 2254 2242070
SGTC_1037 k284-1091 78.7 µM 0.095808123247409 0.465157892558225 no 1558 0.461836482811803 2227 3334711
SGTC_3301 9125354 19.7965 µM 0.0954720351402969 0.46529003959797 no 1559 0.461969950751764 2207 41905162
SGTC_2150 5556613 200 µM 0.0939232468580616 0.465899059468564 no 1560 0.462585063571019 2162 743190
SGTC_225 nsc-122657 1.016 µM 0.093636492705067 0.466011826730887 no 1561 0.462698959983208 2204 275685
SGTC_1611 st001856 99.4 µM 0.0924839965575691 0.466465078063176 no 1562 0.463156752810443 2076 647478
SGTC_1986 st071812 45 µM 0.0921946658131093 0.466578872321085 no 1563 0.46327168803047 2242 11838594
SGTC_1406 3909-7906 11.9 µM 0.0921028547596945 0.466614982330934 no 1564 0.463308160162662 2235 X1406
SGTC_858 0438-0351 2.77 µM 0.091212111600855 0.466965332847081 no 1565 0.463662025702896 2140 2799119
SGTC_1223 0764-0573 147 µM 0.0901441853786107 0.467385407401706 no 1566 0.464086318634537 2233 1609797
SGTC_2014 4013930 200 µM 0.0863605937171416 0.468873992805993 no 1567 0.465589885756598 2278 64556
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0850975986527181 0.469370993190681 no 1568 0.466091899690647 2253 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2111 5486399 200 µM 0.0844057262175817 0.469643271756267 no 1569 0.466366927336004 2249 689674
SGTC_531 3788-1495 174 µM 0.0842539068684288 0.469703020446405 no 1570 0.466427279513528 2158 2896655
SGTC_3042 9091578 49.47 µM 0.0829136658580628 0.470230503373612 no 1571 0.466960093837426 2240 25236497
SGTC_21 0849-0113 22.993 µM 0.0821198199962193 0.470542964515872 no 1572 0.467275716138211 2228 1560156
SGTC_699 0375-0592 111 µM 0.080551982523431 0.471160125181782 no 1573 0.467899127220043 2293 762578
SGTC_2721 ifenprodil 61.44 µM 0.0805135036602631 0.471175272807786 no 1574 0.467914428366957 2246 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_500 h-89 112 µM 0.0804483728764516 0.471200912349329 no 1575 0.467940327776813 2260 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2102 5377816 72.7585 µM 0.0804121929612464 0.471215155073645 no 1576 0.467954714864096 2243 1379702
SGTC_1360 1598-0022 39.8 µM 0.0801386907491517 0.471322824194273 no 1577 0.468063475460165 2228 761525
SGTC_1319 1306-0155 43.7 µM 0.0792899195304579 0.47165697173388 no 1578 0.468401012053875 2243 3122360
SGTC_1255 0566-0045 221 µM 0.0784023106954206 0.472006430355441 no 1579 0.46875401776093 2185 2788469
SGTC_2543 pimpinellin 60.67 µM 0.0779129290403278 0.472199113019438 no 1580 0.46894865739451 2161 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2235 salicylic acid 500 µM 0.0775331494047659 0.472348646919223 no 1581 0.469099710611256 2277 338 A COX inhibitor and kinase inhibitor.
SGTC_3237 9133362 49.47 µM 0.0767033537153032 0.472675383039498 no 1582 0.469429768262232 2265 43845137
SGTC_1232 0279-0259 161 µM 0.0764605368323847 0.472770996864641 no 1583 0.469526354537988 2193 1560000
SGTC_11 0438-0307 1.3 µM 0.0756623805651938 0.473085297295387 no 1584 0.469843853061981 2283 4011476
SGTC_1749 st037932 54.2 µM 0.0753558048292848 0.473206026097045 no 1585 0.46996581090981 2179 594497
SGTC_2711 st079103 59.1 µM 0.0738625778094037 0.473794090359817 no 1586 0.47055986652952 2237 54693780
SGTC_3146 9095609 49.47 µM 0.0726598511415057 0.474267791049344 no 1587 0.471038399104329 2229 17173999
SGTC_1101 ebselen 5.29 µM 0.072146095475022 0.474470147748593 no 1588 0.471242821445991 2291 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_991 3996-0057 64.7 µM 0.0711997468354376 0.474842910206365 no 1589 0.47161939145159 2211 715343
SGTC_3079 9117512 49.47 µM 0.0702437245403818 0.47521950543441 no 1590 0.471999836550778 2287 7185044
SGTC_2006 4011487 200 µM 0.0700931010471844 0.475278840899085 no 1591 0.472059778882575 2268 45595294
SGTC_1070 indatraline 8.81 µM 0.0683336630196967 0.475971980693785 no 1592 0.472760013766191 2192 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2493 resveratrol 26.09 µM 0.0664673645267816 0.476707298156326 no 1593 0.473502869783507 2283 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3093 9117344 49.47 µM 0.0664029826667019 0.476732665895959 no 1594 0.473528497810784 2221 24824913
SGTC_594 1487-1584 10.8 µM 0.0655361699817686 0.477074216557708 no 1595 0.473873554371221 2263 5013332
SGTC_2940 9060638 45.86 µM 0.0645002486204391 0.477482423270604 no 1596 0.474285954577521 2201 4027022
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0637692122666321 0.477770503731938 no 1597 0.474576996698672 2295 1273210
SGTC_2306 7482397 179.52 µM 0.0633471674860917 0.477936824774479 no 1598 0.474745028467398 2266 891448
SGTC_1889 st059080 5.18 µM 0.0629376042883469 0.478098230700712 no 1599 0.474908095147872 2295 176925 Isolated from Daphnopsis sellowiana.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0628905321834209 0.478116781711177 no 1600 0.47492683707207 2217 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1489 4065-0444 182 µM 0.0620895266583093 0.478432463418549 no 1601 0.475245768711413 2303 2877968
SGTC_523 1934-0222 13.7 µM 0.059918219925266 0.479288257609015 no 1602 0.476110384282131 2293 1361595
SGTC_2175 5807670 165.306 µM 0.0597070744112668 0.479371483207876 no 1603 0.476194468612159 2292 241186
SGTC_45 0kpi-0036 14.9 µM 0.0593031281393133 0.479530706097686 no 1604 0.476355334803604 2256 2795021
SGTC_1062 mesoridazine 14.2 µM 0.0589449454688482 0.479671893151112 no 1605 0.476497979478138 2304 4078 A neuroleptic.
SGTC_2889 9059656 51.95 µM 0.0578852786069975 0.480089603384456 no 1606 0.476920004714455 2254 3949838
SGTC_3090 9117696 49.47 µM 0.0571939961350442 0.480362111935138 no 1607 0.477195330361855 2289 7923821
SGTC_1897 st060201 15 µM 0.0559559475956674 0.480850182478691 no 1608 0.477688450434666 2151 611878
SGTC_2634 4'-methoxyflavone 100 µM 0.054213100621605 0.48153730601908 no 1609 0.478382691624083 2248 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1251 0490-5699 265 µM 0.0534514730318637 0.481837597714367 no 1610 0.478686097123887 2315 3883818
SGTC_829 1635-0120 117 µM 0.0532887411366224 0.481901760383113 no 1611 0.478750925364068 2303 285054
SGTC_2751 anetholtrithion 17.25 µM 0.0531287119628194 0.481964857867795 no 1612 0.47881467745716 2285 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_452 diindolylmethane 8 µM 0.0528223497449768 0.482085653884915 no 1613 0.478936726918063 2286 3071 Inhibits expression of several cancer promoting factors.
SGTC_1570 verbenone 133 µM 0.052529998402394 0.482200927066787 no 1614 0.47905319652806 2328 29025 A natural terpanoid with antifungal properties.
SGTC_855 0428-0020 25 µM 0.0521617100476967 0.482346144081953 no 1615 0.479199921166291 2204 6812414
SGTC_1270 0831-1170 17.3 µM 0.0518259464464443 0.482478538547438 no 1616 0.47933369052692 2316 6764716
SGTC_2816 7982706 58.44 µM 0.051551681427101 0.482586685029458 no 1617 0.479442960371336 2260 2981853
SGTC_1866 st057638 64 µM 0.0514825004823051 0.482613964233367 no 1618 0.479470522975207 2268 688802
SGTC_985 1493-0307 8.71 µM 0.0508821765256602 0.482850685416679 no 1619 0.479709704091376 2315 3278274
SGTC_893 0958-0369 48.9 µM 0.0500116182205588 0.483193976775028 no 1620 0.480056564953698 2326 6819948
SGTC_290 2043-6722 48.1 µM 0.0488786187747197 0.483640776406487 no 1621 0.480508014118847 2299 773758 YLR208W SEC13
SGTC_40 0327-0103 19.753 µM 0.0488360967592561 0.483657545415548 no 1622 0.480524957714058 2299 409036
SGTC_740 k014-0057 261 µM 0.0483736792784259 0.483839906527517 no 1623 0.480709217816849 2306 4012779
SGTC_1187 1391-0724 117 µM 0.0476576784926765 0.48412227858861 no 1624 0.480994531710993 2227 6997986
SGTC_688 0527-0193 473 µM 0.0473218852521257 0.484254709448324 no 1625 0.481128342855628 2274 4007154
SGTC_741 4582-0002 126 µM 0.0472782704522642 0.484271910474565 no 1626 0.481145723189976 2302 2912688
SGTC_2137 5261020 140 µM 0.0458628921964799 0.484830130243319 no 1627 0.481709765387449 2326 763655
SGTC_2005 4024620 188 µM 0.0458475917737416 0.484836164835913 no 1628 0.481715862958924 2324 236743
SGTC_2944 9067346 25.62 µM 0.0450622142444284 0.485145927800966 no 1629 0.482028859737463 2292 6473075
SGTC_2963 9082507 9 µM 0.0445331007687462 0.485354622003556 no 1630 0.48223973377121 2300 16459611
SGTC_2473 5854593 8.94 µM 0.044052718480071 0.485544099010604 no 1631 0.482431190676938 2319 2872951
SGTC_206 4546-0025 72.014 µM 0.0406644542974722 0.486880621034867 no 1632 0.483781699752138 2282 6620745 YIL048W NEO1
SGTC_1764 st044502 93.5 µM 0.0402937484468871 0.487026857493082 no 1633 0.483929468874964 2290 8407
SGTC_2716 st080858 38.6235 µM 0.0396196260775117 0.487292790495329 no 1634 0.484198190187806 2331 5296050
SGTC_2311 7694451 200 µM 0.039073964928058 0.487508051266083 no 1635 0.484415709045094 2301 2163142
SGTC_2353 9059630 146.67 µM 0.0387390739580093 0.487640165993325 no 1636 0.484549210132052 2300 4779114
SGTC_610 4215-0184 155 µM 0.0360956227092386 0.488683055841949 no 1637 0.485603056313604 2296 5605015
SGTC_2485 5633444 17.78 µM 0.0355959218018016 0.488880205899344 no 1638 0.485802280096689 2300 5724239
SGTC_2969 9091408 28.7 µM 0.0355155922545167 0.488911899062042 no 1639 0.485834306698853 2188 4286311
SGTC_2329 6138490 200 µM 0.0328326295949525 0.489970472229781 no 1640 0.486904028789334 2262 720019
SGTC_627 1391-0720 175 µM 0.0324525388354557 0.490120444376996 no 1641 0.487055582298228 2308 997839
SGTC_134 0269-0018 6.916 µM 0.0323879965961588 0.490145910902877 no 1642 0.487081317398053 2300 4378915
SGTC_1757 st041620 31.8375 µM 0.0316312329454097 0.490444511213965 no 1643 0.487383067778756 2304 5289815
SGTC_2738 aclarubicin 5.55 µM 0.0306325520568031 0.490838574282668 no 1644 0.487781290768732 2338 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_407 eburnamonine 100 µM 0.0297172145584004 0.491199759282276 no 1645 0.488146291376283 2344 3195
SGTC_67 0335-0847 266 µM 0.0288109102699838 0.491557386958332 no 1646 0.488507699677954 2324 4552207 YOR254C SEC63
SGTC_2016 5121758 140 µM 0.0283587134937717 0.491735826363947 no 1647 0.488688026402745 2371 2795203
SGTC_430 0958-0115 16.4 µM 0.0283173724143447 0.491752139870772 no 1648 0.488704512486385 2236 6833180
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0276374087233862 0.492020460714535 no 1649 0.488975672602682 2329 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1758 st042942 75.2445 µM 0.0273641761123767 0.492128282208289 no 1650 0.489084635431523 2352 669317
SGTC_1713 st033146 12.748 µM 0.0269060156802887 0.492309080150285 no 1651 0.489267347718354 2354 674619
SGTC_166 k072-0058 166.424 µM 0.0263033144735579 0.49254691875427 no 1652 0.489507705629826 2373 5846229
SGTC_2834 9001755 58.44 µM 0.0260883702364645 0.492631740927637 no 1653 0.48959342655692 2272 2989575
SGTC_333 3486-0131 40.1 µM 0.025055900406675 0.493039182967813 no 1654 0.490005187752622 2354 6744690
SGTC_2389 9091542 195.52 µM 0.0236403051548335 0.493597828944987 no 1655 0.490569761130538 2310 3626624 YOL127W RPL25
SGTC_1984 st072354 53.1 µM 0.0230828899637611 0.493817808997387 no 1656 0.49079207694083 2321 5762938
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0222946096863023 0.494128901553905 no 1657 0.491106474331117 2285 688788
SGTC_341 1486-1430 230 µM 0.0213961139803288 0.494483494657649 no 1658 0.491464836725913 2372 2054753 YPL210C SRP72
SGTC_2383 9036125 200 µM 0.021379913551405 0.494489888229745 no 1659 0.491471298283892 2335 79580
SGTC_2539 epi(13)torulosol 80 µM 0.0212886211770183 0.49452591720207 no 1660 0.491507710384456 2347 6708597
SGTC_2960 9079389 5.97 µM 0.02086760038099 0.494692075646768 no 1661 0.491675636071957 2381 16457355
SGTC_1482 3346-2049 8.48 µM 0.0194501767845331 0.495251477182162 no 1662 0.492240991340074 2367 3826804
SGTC_2700 st077718 96.8 µM 0.0191093365640218 0.49538599489161 no 1663 0.492376941644914 2357 904970
SGTC_516 3992-2719 87.3 µM 0.0184936191408861 0.495628998334788 no 1664 0.492622533942173 2362 5350887 YDR037W KRS1
SGTC_3131 9127911 49.47 µM 0.0160857235987588 0.496579330349789 no 1665 0.493583001480397 2356 45595681
SGTC_2886 9058944 51.95 µM 0.0155928584685896 0.496773853613553 no 1666 0.493779601553999 2380 4949929
SGTC_636 0kpi-0074 126 µM 0.013648134880148 0.497541401217994 no 1667 0.49455535097878 2368 616434
SGTC_1121 fusaric acid 630.51 nM 0.0131890383630865 0.497722599832331 no 1668 0.49473848750023 2375 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2696 st077691 74.316 µM 0.0130914625174008 0.497761111639214 no 1669 0.49477741127005 2367 757133
SGTC_34 0469-0683 81.75 µM 0.0122909288164172 0.498077071729246 no 1670 0.495096752283135 2365 3690923
SGTC_1751 st044839 27.194 µM 0.011253954456737 0.498486353591986 no 1671 0.495510416514436 2389 5291326
SGTC_125 0133-0007 11.75 µM 0.011181954780552 0.498514771100857 no 1672 0.49553913842216 2381 26541
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0111531586187231 0.49852613664276 no 1673 0.495550625712289 2314 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_637 1181-0519 7.26 µM 0.0108037123572843 0.498664059495735 no 1674 0.495690026199048 2387 6252091 YGR060W ERG25
SGTC_237 nikkomycin 200 µM 0.00995813997518525 0.498997798865105 no 1675 0.49602734258765 2384 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2671 danthron 100 µM 0.00944252555647234 0.499201307326678 no 1676 0.49623303329977 2377 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1808 st050063 61.5 µM 0.00782674854336003 0.499839041359229 no 1677 0.496877610966563 2386 4011993
SGTC_2904 7225135 42.03 µM 0.00780709528026659 0.499846798348004 no 1678 0.496885451244618 2380 4446116
SGTC_2746 daunorubicin 9.88 µM 0.00703078573517799 0.499846798348004 no 1679 0.497195145414051 2390 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1024 4507-0395 26 µM 0.0069576783197875 0.499817943424949 no 1680 0.497224310339682 2345 4201836
SGTC_877 0771-0151 33.1 µM 0.00646500603433586 0.499623489573096 no 1681 0.497420853716329 2351 6166523
SGTC_1728 st035614 33.7865 µM 0.00594376091985927 0.49941775835012 no 1682 0.497628796426241 2359 15945546
SGTC_3275 9138069 49.47 µM 0.00592752881067791 0.499411351670359 no 1683 0.49763527198682 2340 17617007
SGTC_1231 0242-0792 125 µM 0.00591573585468147 0.499406697087882 no 1684 0.497639976613091 2388 3707635
SGTC_755 1995-0008 37.3 µM 0.00550071477237101 0.499242891745346 no 1685 0.497805543371473 2392 689533
SGTC_1336 1486-0901 104 µM 0.00464902475065583 0.498906737262608 no 1686 0.498145314145354 2368 5006114
SGTC_105 0111-0055 734.78 µM 0.00457482654433179 0.498877451923277 no 1687 0.498174914632179 2367 5179370
SGTC_928 2764-0428 58.7 µM 0.00404344943092888 0.498667722523747 no 1688 0.498386901458893 2357 662578
SGTC_565 1418-0001 44.5 µM 0.0026506396781762 0.498117995901716 no 1689 0.498942549000522 2399 2862145
SGTC_213 1246-0773 967 nM 0.002365481871311 0.498005447672278 no 1690 0.499056310148081 2386 6251622
SGTC_2684 capsaicin 100 µM 0.00226472742294394 0.497965681185766 no 1691 0.499096505249739 2395 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2907 7721985 69.9 µM 0.00146254373311387 0.497649070341822 no 1692 0.499416529675935 2399 3267881
SGTC_3097 9117246 49.47 µM 0.0013868962075391 0.497619213379606 no 1693 0.499446708641659 2401 16423892
SGTC_1810 st050138 53 µM 0.000968103038597001 0.497453922140677 no 1694 0.499613782826447 2402 3444541
SGTC_2783 7738165 71.43 µM 0.000442402594917617 0.497246436862614 no 1695 0.499823506905685 2401 17201110
SGTC_1060 3448-7350 82 µM 0.000427531082615234 0.497240567333025 no 1696 0.499829439780155 2404 570178
SGTC_336 4111-0029 111 µM 8.57024714159044e-05 0.497105653638971 no 1697 0.499965809660659 2404 3131175
SGTC_892 0929-0076 29 µM -0.000853867701192743 0.496734823697099 no 1698 0.499659356113518 2410 5751038
SGTC_628 1636-0253 16 µM -0.00124194808662657 0.496581656776109 no 1699 0.499504534525552 2404 4456143
SGTC_685 1278-0033 54.9 µM -0.00232819435519994 0.496152941656806 no 1700 0.499071185673824 2410 3590572
SGTC_432 NS 1619 61.3 µM -0.0025716332525654 0.496056862806146 no 1701 0.498974067896665 2443 4552 A K+/calcium channel activator.
SGTC_2521 angolensin 13.4 µM -0.00324880030796256 0.49578960422094 no 1702 0.498703918476532 2414 821428 A flavenoid.
SGTC_135 0933-0004 26.348 µM -0.00339227811153769 0.495732977849447 no 1703 0.498646679429995 2414 21230617 YGL099W LSG1
SGTC_1885 st057546 99.9 µM -0.00584936368762601 0.494763254406921 no 1704 0.497666454818632 2429 702008
SGTC_975 1335-0046 28.5 µM -0.00592304511246659 0.494734175443713 no 1705 0.497637060692209 2421 16486740
SGTC_3313 9133968 57.047 µM -0.00604330648373824 0.494686713392534 no 1706 0.497589084205287 2416 1494643
SGTC_997 3996-0078 137 µM -0.00634080643900571 0.494569303130876 no 1707 0.497470401170419 2426 735687
SGTC_1182 1222-0449 220 µM -0.00737508126822202 0.494161123675093 no 1708 0.497057794932717 2418 658318
SGTC_2486 5283202 22.39 µM -0.00781899097087826 0.493985935318662 no 1709 0.496880705695524 2430 1377751
SGTC_2481 5478948 45.16 µM -0.00874811916489956 0.493619259943301 no 1710 0.496510049905263 2430 77792
SGTC_140 0062-0056 502.533 µM -0.00910009012804491 0.493480357913156 no 1711 0.496369639398548 2424 3758964
SGTC_799 1310-0557 151 µM -0.00917439573953475 0.493451034002953 no 1712 0.496339996985897 2457 5354492
SGTC_2511 berberine 10.47 µM -0.0106857179439579 0.492854614855209 no 1713 0.495737096442165 2428 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2284 7945075 39.21 µM -0.0109895295230632 0.492734722357669 no 1714 0.495615900276153 2438 1245402
SGTC_2133 5320837 200 µM -0.0110628437043149 0.492705790640907 no 1715 0.495586653927397 2437 2841355
SGTC_619 1652-1634 108 µM -0.0123598447831058 0.49219396616369 no 1716 0.495069260878494 2430 5400454
SGTC_1926 methyl fluorone black 53.6 µM -0.0138964935454336 0.491587588264247 no 1717 0.494456279602956 2427 72721 Reacts with homocysteine.
SGTC_1212 0520-0165 585 µM -0.0140878680685295 0.491512071180381 no 1718 0.494379939687741 2437 5403258
SGTC_2759 disulfiram 3.38 µM -0.0148482537550933 0.491212023251204 no 1719 0.49407662144294 2445 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1361 1608-0041 5.61 µM -0.0149635822166596 0.491166515110223 no 1720 0.49403061715456 2435 X1361
SGTC_671 0560-0003 407 µM -0.0151093189426781 0.491109008156529 no 1721 0.493972483185063 2452 3238678
SGTC_61 0978-8327 98.565 µM -0.0153958489418782 0.490995945449877 no 1722 0.493858187549886 2428 6150059 YHR072W ERG7
SGTC_1127 asiatic acid 681.4 nM -0.0155944149473767 0.490917593135461 no 1723 0.493778980684292 2442 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_147 4466-0538 29.23 µM -0.0166431535053052 0.490503776457891 no 1724 0.493360648899625 2486 6742687 YHR072W ERG7
SGTC_2167 5876490 200 µM -0.0170293391023143 0.490351395901419 no 1725 0.493206604971984 2476 686534
SGTC_440 fluspirilene 35.1 µM -0.0173048700095216 0.490242678172499 no 1726 0.493096700240066 2559 3396 An atypical antipsychotic.
SGTC_2791 5663188 71.43 µM -0.0174529731429947 0.49018424061249 no 1727 0.493037624560214 2453 54690634
SGTC_2415 st077333 57.7 µM -0.0174960570228273 0.490167240898148 no 1728 0.493020439202995 2446 2766255
SGTC_2868 9035608 32.47 µM -0.0176390429053023 0.490110822728658 no 1729 0.492963404890634 2428 6462614
SGTC_580 1123-0028 41 µM -0.0176812386076789 0.490094173540304 no 1730 0.492946573865746 2435 1677248 YPR107C YTH1
SGTC_3282 9108498 15.4605 µM -0.0184658592045613 0.489784588407658 no 1731 0.492633606663641 2459 16459645
SGTC_3186 9110464 49.47 µM -0.0188633416633027 0.489627757416149 no 1732 0.492475061724517 2453 17018021
SGTC_2440 5628896 157.78 µM -0.0189350784167722 0.489599453076407 no 1733 0.492446448011087 2450 5522048
SGTC_9 0092-0002 10.449 µM -0.0189803674374161 0.48958158393917 no 1734 0.492428383552347 2435 759368
SGTC_1800 st050079 29.0735 µM -0.019410319669891 0.489411943970456 no 1735 0.492256889027032 2428 3645560
SGTC_2847 9005661 71.43 µM -0.0194307876100411 0.489403868281964 no 1736 0.492248725040015 2441 2991449
SGTC_397 arbidol 50 µM -0.0196519760169262 0.489316597996199 no 1737 0.492160500479324 2473 131410 A RNA synthesis inhibitor.
SGTC_1264 0783-0040 158 µM -0.0240121900681561 0.487596377396889 no 1738 0.490421442621473 2441 2855798
SGTC_2136 5328288 199.296 µM -0.0245296745622964 0.48739223067197 no 1739 0.490215056977201 2457 262395
SGTC_1134 3477-0009 42.5 µM -0.0252788190160314 0.48709670036657 no 1740 0.489916284254464 2466 3973534
SGTC_3044 9093193 49.47 µM -0.0260157612852003 0.486805990618581 no 1741 0.489622383509153 2483 25236277
SGTC_2406 ethylparaben 405.7 µM -0.0278337359725564 0.486088864389009 no 1742 0.488897379482071 2472 8434 A possible steroid mimic.
SGTC_3261 9137475 49.47 µM -0.0282160554280701 0.485938058635166 no 1743 0.488744915971355 2451 17027690
SGTC_3175 9106517 49.47 µM -0.0283141633629856 0.48589936032349 no 1744 0.488705792199523 2478 41468073
SGTC_1198 1612-1005 86.7 µM -0.028577314099278 0.485795562146664 no 1745 0.488600852710011 2486 6998509
SGTC_486 niguldipine 82 µM -0.0305526264521718 0.485016443644362 no 1746 0.487813161554169 2451 1236 A calcium channel blocker.
SGTC_1192 1488-0095 21.4 µM -0.0309171729556651 0.484872662459524 no 1747 0.487667797215827 2509 915875
SGTC_1854 st056233 32.9 µM -0.0310117219247821 0.484835371617737 no 1748 0.487630095712869 2450 5393174
SGTC_1111 tnp00062 510.699 nM -0.0310591831787384 0.484816652583532 no 1749 0.487611170528544 2477 676306
SGTC_1616 st002734 56.1 µM -0.0322623274013474 0.484342135787631 no 1750 0.487131425966709 2484 4026101
SGTC_2341 7987486 176.74 µM -0.0324382087551982 0.484272770503625 no 1751 0.487061296164833 2476 1258686
SGTC_1390 3413-2614 145 µM -0.0329853807668777 0.484056976138922 no 1752 0.486843122878093 2476 3421432
SGTC_1637 st007924 17.4 µM -0.0331469456337645 0.483993258879986 no 1753 0.486778703048754 2464 683336
SGTC_2800 7887935 81.82 µM -0.0338150818255698 0.483729766553977 no 1754 0.486512304633 2497 2961002
SGTC_2947 9072639 7.68 µM -0.0345539849882123 0.483438374193979 no 1755 0.486217697113866 2490 16488146
SGTC_3171 9103192 49.47 µM -0.0353020304225755 0.48314338551721 no 1756 0.4859194521492 2468 13018434
SGTC_2469 5655019 90.81 µM -0.0363587239795714 0.482726698468754 no 1757 0.485498162947183 2524 2788239
SGTC_2338 7999974 200 µM -0.0371759170291413 0.48240446681335 no 1758 0.485172370380994 2529 315925
SGTC_1126 isoteolin 1.0172 µM -0.0371977141178115 0.482395872046025 no 1759 0.485163680611175 2470 133323
SGTC_2205 7238770 200 µM -0.0372034122697943 0.48239362522023 no 1760 0.485161408949829 2476 279867
SGTC_228 caffeine 993.056 µM -0.0376070623827185 0.482234464257703 no 1761 0.485000488469861 2467 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1961 st076550 68.7 µM -0.0389992485610807 0.481685541186719 no 1762 0.48444549386037 2517 1579337
SGTC_1510 1123-0200 71.5 µM -0.0396873473398509 0.481414244472821 no 1763 0.484171194545288 2497 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1229 0139-0193 12.2 µM -0.040150235053685 0.481231746563141 no 1764 0.483986676141342 2487 3090752
SGTC_1226 3909-7979 35.4 µM -0.041966172272782 0.480515834282883 no 1765 0.483262832481832 2531 6615510
SGTC_2419 paclitaxel 166.5 µM -0.0419894822107938 0.48050664501254 no 1766 0.48325354135174 2456 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2359 9039622 200 µM -0.0437609903057711 0.479808309736875 no 1767 0.48254746125171 2504 6463596
SGTC_3013 9080133 71.4286 µM -0.044449456137791 0.479536930473241 no 1768 0.482273070140448 2538 17050193
SGTC_834 0312-0008 75.7 µM -0.0450346231343327 0.479306276967206 no 1769 0.48203985583466 2489 6385573 YIL048W NEO1
SGTC_2983 9022671 12.99 µM -0.0466625403507726 0.478664642454239 no 1770 0.481391093137643 2564 6405161
SGTC_1648 st011736 69.8 µM -0.0472783605301764 0.478421934681142 no 1771 0.481145687294229 2526 2855514
SGTC_1514 1189-1591 158 µM -0.048327292190484 0.478008546973134 no 1772 0.480727701969017 2504 767698 YMR146C TIF34
SGTC_2413 inermin 26.06 µM -0.0483918429457568 0.477983108058543 no 1773 0.480701980038371 2556 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_840 0245-0196 390 µM -0.0511333814087589 0.476902774731087 no 1774 0.479609618128958 2600 3827528
SGTC_2575 plumbagin 510 nM -0.0511383715416898 0.476900808466774 no 1775 0.479607629955063 2495 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2985 9022375 71.43 µM -0.0514494563088332 0.476778232708941 no 1776 0.479483688245839 2659 4939335
SGTC_1020 4335-0961 93.3 µM -0.0526839984189044 0.476291811716559 no 1777 0.478991844365058 2494 669075
SGTC_693 4161-2696 114 µM -0.0544036738976271 0.475614302731083 no 1778 0.478306775922387 2561 805759
SGTC_2357 9067248 200 µM -0.0581643587095909 0.474132935638754 no 1779 0.476808855133485 2552 9150235
SGTC_1700 st030840 7.9285 µM -0.0598549309401242 0.473467119528824 no 1780 0.476135587698847 2597 5499307
SGTC_1683 st010134 710 nM -0.0605673565726549 0.473186559426502 no 1781 0.475851885728744 2512 3818134
SGTC_2739 tacrine 100.86 µM -0.0606666684042545 0.473147450520125 no 1782 0.475812338763098 2579 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2819 7996655 46.38 µM -0.0621640879608256 0.472557799687429 no 1783 0.475216080405259 2541 6456960
SGTC_1356 1502-0781 85.8 µM -0.062178144191637 0.472552264936269 no 1784 0.475210483607449 2502 567702
SGTC_2915 7971052 15.16 µM -0.0636770706833083 0.471962081501613 no 1785 0.474613681314881 2500 5741558
SGTC_2798 7813637 45.45 µM -0.0646207018812872 0.471590570090893 no 1786 0.47423800072035 2581 956368
SGTC_2489 cantharidin 73.42 µM -0.065589121793951 0.471209324967515 no 1787 0.473852475007646 2540 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1959 st077091 55.8 µM -0.0661938538816089 0.470971268914473 no 1788 0.473611744968245 2510 821356 YKL052C ASK1
SGTC_2934 9036370 36.88 µM -0.0664881864058021 0.470855407073912 no 1789 0.473494581390283 2587 6462800
SGTC_1267 0828-0272 9.49 µM -0.0672012821010299 0.470574712428527 no 1790 0.473210732232422 2561 745334
SGTC_185 k048-0037 25.491 µM -0.0692357964394623 0.469773950837577 no 1791 0.472400965010809 2513 6827589
SGTC_457 grayanotoxin iii 135 µM -0.0693636115976804 0.469723648299032 no 1792 0.472350096433795 2585 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3087 9117406 49.47 µM -0.0699110864922291 0.469508191249389 no 1793 0.472132214488642 2626 42546093
SGTC_1836 st055642 81 µM -0.0713019171447708 0.468960874448755 no 1794 0.471578734727114 2536 8571
SGTC_47 0149-0135 24.25 µM -0.0729405176724854 0.468316131092406 no 1795 0.470926725678378 2508 5239155
SGTC_1738 st035555 74 µM -0.074335104311067 0.46776746574644 no 1796 0.470371872543708 2607 5331140
SGTC_2524 avocatin b 10.57 µM -0.0744961907179533 0.467704094240312 no 1797 0.470307786056663 2579 6710748
SGTC_1977 st070720 65.3 µM -0.0752163550812464 0.467420791103369 no 1798 0.470021285871393 2640 682188
SGTC_2046 4110841 106 µM -0.0761703372732535 0.467045532556628 no 1799 0.469641790768603 2557 44119630 YMR134W ERG29
SGTC_1922 5578187 25 µM -0.0763564966536489 0.466972308285919 no 1800 0.469567739579283 2614 1350412
SGTC_324 1315-0088 19.6 µM -0.0772400321424054 0.466624792106706 no 1801 0.469216297854618 2526 6787421
SGTC_2142 5622915 118.518 µM -0.0792051962350574 0.465851936479373 no 1802 0.468434705790958 2589 5322196
SGTC_3107 9121808 49.47 µM -0.0794572011064417 0.465752837784139 no 1803 0.46833448625264 2541 662681
SGTC_474 dl-dihydrosphingosine 5 µM -0.0802668309737505 0.465434472373944 no 1804 0.468012519058711 2694 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_713 1488-1073 324 µM -0.0805092978953416 0.465339133001687 no 1805 0.467916100795201 2535 3312542
SGTC_3048 9093155 49.47 µM -0.0815301258920715 0.464937759513412 no 1806 0.467510183811407 2545 25236002
SGTC_3092 9117248 49.47 µM -0.0818165177253884 0.46482516114587 no 1807 0.46739631043277 2541 17141857
SGTC_2229 7354935 190 µM -0.0822809719081688 0.464642561432054 no 1808 0.467211642662311 2552 318112
SGTC_3155 9099265 49.47 µM -0.0824037008355476 0.464594311914842 no 1809 0.467162846609875 2621 25236499
SGTC_2504 purpurogallin 52.29 µM -0.0833845783044892 0.464208709579068 no 1810 0.466772875267506 2592 5281571 An antioxidant.
SGTC_2259 7964009 200 µM -0.0834582444460407 0.46417975131424 no 1811 0.466743588810668 2709 313134
SGTC_312 4092-0653 6.84 µM -0.0837379174518042 0.46406981318761 no 1812 0.466632404617033 2644 1148278
SGTC_2981 9013952 38.96 µM -0.0839457820677777 0.463988104373762 no 1813 0.466549769583931 2619 2996344
SGTC_1621 st003705 32.4 µM -0.0841760465662512 0.463897592237596 no 1814 0.466458231327544 2547 24207032
SGTC_2099 5377090 177.372 µM -0.084885983391535 0.463618542769997 no 1815 0.466176017598778 2624 2243829
SGTC_1103 duloxetine 36.1 µM -0.0851714103423767 0.463506357206411 no 1816 0.466062559606516 2703 60835 A selective serotonin reuptake inhibitor.
SGTC_939 1165-0479 45.3 µM -0.0867835295990677 0.462872776942266 no 1817 0.465421789850415 2567 1377347
SGTC_2483 5729050 27.16 µM -0.0875716287046222 0.462563079661891 no 1818 0.46510857626906 2585 2865180
SGTC_937 3122-0005 46.7 µM -0.087686467003127 0.462517953840614 no 1819 0.465062937978011 2566 759535
SGTC_2331 7980721 200 µM -0.0885732604729024 0.462169503771998 no 1820 0.464710529796003 2658 2981221
SGTC_1329 1447-1697 50.6 µM -0.0892789082702623 0.461892252473662 no 1821 0.464430127942768 2687 2840515
SGTC_1067 clotrimazole 1.36 µM -0.0895428483102448 0.461788554330681 no 1822 0.464325251149115 2580 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2033 5192550 145 µM -0.0897195354546539 0.46171913801256 no 1823 0.46425504575038 2601 182073
SGTC_17 0960-0276 49.807 µM -0.0903869410747078 0.461456940223248 no 1824 0.463989866863619 2570 6821114
SGTC_2979 9012552 45.46 µM -0.0905229245234086 0.461403519649683 no 1825 0.46393583880065 2571 17100905
SGTC_1561 5-methoxyflavone 52.9 µM -0.0915563941897968 0.460997547902504 no 1826 0.463525249132609 2553 94525
SGTC_2691 st077356 60.2 µM -0.0917311234782087 0.460928914039787 no 1827 0.463455834337618 2682 2839272
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0917554333794984 0.46091936517516 no 1828 0.463446176818646 2713 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1247 0448-0043 5.84 µM -0.0943506022282052 0.459900120459508 no 1829 0.462415327196608 2653 3089013 YGL099W LSG1
SGTC_3308 9128332 17.569 µM -0.0951798119237731 0.459574506079377 no 1830 0.462086002465264 2665 17332805 YDL196W YDL196W
SGTC_3283 9109332 35.8195 µM -0.0961257524780197 0.459203086901183 no 1831 0.461710349245298 2548 17027281
SGTC_3263 9137018 49.47 µM -0.0978821078668544 0.45851355676689 no 1832 0.461012953804079 2581 43844957
SGTC_2863 9028737 58.44 µM -0.0994467185639489 0.457899409015554 no 1833 0.460391795263152 2706 6460917
SGTC_1175 0741-0056 27.6 µM -0.100719899833205 0.457399728502148 no 1834 0.459886406960834 2685 765927
SGTC_1139 k015-0024 46.9 µM -0.100906203089839 0.45732661641439 no 1835 0.459812459445618 2565 2766652
SGTC_1165 k072-0275 30.3 µM -0.100953290131134 0.457308137997103 no 1836 0.459793769870441 2598 6153523 YGL055W OLE1
SGTC_309 k408-0051 1.48 µM -0.10114127753678 0.457234366821373 no 1837 0.459719155646544 2607 3640463
SGTC_1249 0481-0015 10.2 µM -0.102868618646801 0.456556582283059 no 1838 0.459033622114747 2600 4227577
SGTC_1306 1185-0270 9.02 µM -0.102920184570483 0.456536350467327 no 1839 0.459013158899456 2626 1548076
SGTC_415 dibenzyl ketone 100 µM -0.102945378548982 0.456526465687196 no 1840 0.459003161061097 2691 7593
SGTC_1288 0973-0013 65.5 µM -0.103061393199703 0.456480948042352 no 1841 0.458957122786824 2666 4315430
SGTC_1712 st032288 53.4 µM -0.103825046866858 0.456181347433938 no 1842 0.458654094679692 2595 2883011
SGTC_2924 9010168 62.78 µM -0.104936776295756 0.455745232495385 no 1843 0.458212988395179 2686 2993929
SGTC_2496 diffractaic acid 79.83 µM -0.105542737619023 0.455507545288024 no 1844 0.457972579811106 2663 94870 An apoptosis inducer which activates caspases.
SGTC_2081 5214970 32.255 µM -0.105658336089028 0.455462203808273 no 1845 0.457926719115266 2608 2063512
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.107540718488854 0.454723954262879 no 1846 0.457180011961328 2635 279621
SGTC_907 3448-6986 75.5 µM -0.108388931060227 0.454391345628405 no 1847 0.456843590570472 2665 590582
SGTC_983 1491-0821 12.2 µM -0.108407258413335 0.454384159296306 no 1848 0.45683632184442 2710 46495113
SGTC_412 gemfibrozil 100 µM -0.108687213915005 0.454274387898683 no 1849 0.45672529179499 2584 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1245 0418-0076 17.2 µM -0.108732566344951 0.454256605402434 no 1850 0.456707305388029 2748 6790114
SGTC_3069 9117009 49.47 µM -0.108845041317604 0.454212504836397 no 1851 0.456662699106261 2601 41904981
SGTC_3113 9123498 49.47 µM -0.109093897772222 0.45411493215397 no 1852 0.456564007437382 2583 8897275
SGTC_380 3970-0968 6 µM -0.109621214829504 0.453908188628276 no 1853 0.456354892526826 2601 2891601
SGTC_1903 st060211 78.3 µM -0.112888231611287 0.452627580244394 no 1854 0.45505958325029 2677 688960
SGTC_1129 3453-1384 223 µM -0.113011217066551 0.452579381825005 no 1855 0.455010831127322 2832 1084452
SGTC_3264 9137442 49.47 µM -0.113170754183389 0.452516859725983 no 1856 0.454947590730775 2747 17015726
SGTC_226 1,3-diallylurea 8.28947 mM -0.113650097197805 0.452329013781175 no 1857 0.45475758638557 2702 74537 YKL182W FAS1
SGTC_1034 k072-0165 12.7 µM -0.113862335232504 0.452245844901063 no 1858 0.454673461731441 2643 5835461
SGTC_2171 5739187 198.077 µM -0.11425262532206 0.452092908937957 no 1859 0.454518768007407 2588 2262761
SGTC_557 1315-0110 16.2 µM -0.114467317581658 0.452008784369787 no 1860 0.454433676433605 2620 6833801
SGTC_1193 1488-0126 41.5 µM -0.114655866605437 0.451934905489705 no 1861 0.454358948248448 2641 1384710
SGTC_3003 9075612 71.4286 µM -0.115805988475909 0.45148429110363 no 1862 0.453903152167247 2710 6501993
SGTC_1494 4358-1428 177 µM -0.116008325424394 0.451405022527891 no 1863 0.453822971807004 2642 1564571
SGTC_2075 5212009 200 µM -0.118406152273484 0.450465785809181 no 1864 0.452872925631984 2685 780898
SGTC_1782 st039423 80.636 µM -0.118682936011611 0.450357386457149 no 1865 0.452763278038031 2661 2068169
SGTC_2670 beta-carotene 100 µM -0.118749029816396 0.450331502082074 no 1866 0.452737095577482 2622 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1000 4048-0884 8.67 µM -0.119118555521898 0.450186788299742 no 1867 0.452590715114364 2741 13040088
SGTC_52 0329-0193 875 nM -0.120545338743106 0.44962809329592 no 1868 0.45202558317262 2839 3739292
SGTC_1107 amlodipine 47 µM -0.12109127983401 0.449414341857707 no 1869 0.4518093680175 2654 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1145 3546-0597 10.2 µM -0.121153630459543 0.449389930750223 no 1870 0.451784675510266 2667 875334
SGTC_1118 chelidonine 707.474 nM -0.121581797592489 0.449222302744739 no 1871 0.451615114972985 2630 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3335 9143315 29.6265 µM -0.121632138697956 0.449202594729393 no 1872 0.451595179727624 2699 4899691
SGTC_2895 9054447 58.44 µM -0.123109084307761 0.448624441973931 no 1873 0.451010358883443 2630 2697450
SGTC_777 1315-0167 517 µM -0.125548753934195 0.447669668835934 no 1874 0.450044565142539 2723 4221767
SGTC_511 blebbistatin 171 µM -0.125836204464309 0.447557193932845 no 1875 0.449930791265936 2774 3476986 A myosin inhibitor.
SGTC_19 0279-0214 38.434 µM -0.127081457647217 0.447069994627618 no 1876 0.449437963559442 2629 3566274 YBR002C RER2
SGTC_643 k048-0106 28.4 µM -0.127576114847052 0.446876484505452 no 1877 0.449242217120285 2745 6763920
SGTC_996 3970-0799 1.8 µM -0.127628150752945 0.446856128769765 no 1878 0.449221626116051 2700 6615648 YGL040C HEM2
SGTC_2324 6149169 200 µM -0.128399255579665 0.446554499532289 no 1879 0.448916510121389 2707 2888231
SGTC_257 daunorubicin 18.5 µM -0.128471183750449 0.44652636532158 no 1880 0.448888050631839 2763 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2255 7941087 197.44 µM -0.129800790645206 0.446006347324901 no 1881 0.448362018681784 2721 935561
SGTC_1047 2043-3044 82 µM -0.130320755876395 0.445803010713455 no 1882 0.448156329644698 2640 669592
SGTC_3294 9122953 26.2835 µM -0.13178578502638 0.445230176038756 no 1883 0.447576865192961 2646 16459826
SGTC_396 dithiazanine 1.25 µM -0.131786357558928 0.445229952197568 no 1884 0.447576638760375 2658 10578 An antihelmenthic.
SGTC_1987 st072290 61.9 µM -0.13326633331244 0.444651389457587 no 1885 0.446991376096301 2688 54697379
SGTC_1463 k081-0032 34.1 µM -0.134355400887003 0.444225718578914 no 1886 0.446560773369646 2692 977755
SGTC_406 estrone 100 µM -0.134741863035862 0.444074682157599 no 1887 0.446407986533272 2730 5870 A steroid.
SGTC_977 1348-1378 135 µM -0.135344506883223 0.443839174220683 no 1888 0.44616974869177 2636 X977
SGTC_2239 6685329 187.64 µM -0.135475829321944 0.443787857190696 no 1889 0.446117836733546 2797 805680
SGTC_1644 st010134 20.9 µM -0.135482595139413 0.443785213329454 no 1890 0.446115162220699 2664 3818134
SGTC_1703 st026983 48.3 µM -0.136137762522613 0.44352920711098 no 1891 0.445856187618272 2693 1104023
SGTC_91 0417-1751 58.384 µM -0.136715714445611 0.443303392343049 no 1892 0.44562775391882 2622 6795624
SGTC_1632 st005650 90 µM -0.141386468782426 0.441479138185952 no 1893 0.443782321618439 2770 2759605
SGTC_3338 9144300 39.5675 µM -0.141432491356831 0.441461169282171 no 1894 0.443764143925671 2732 4901274
SGTC_421 streptovitacin 30 mM -0.14237630095394 0.441092697966391 no 1895 0.443391390386101 2857 91467 include heat shock
SGTC_2371 9071574 200 µM -0.142459270536673 0.441060308367229 no 1896 0.443358624296689 2640 45596039
SGTC_2546 rhodinyl acetate 100 µM -0.142563564004008 0.441019594926365 no 1897 0.443317437594537 2663 6708682
SGTC_353 1988-1175 58.3 µM -0.144270855790759 0.440353201815953 no 1898 0.442643295613292 2603 2788357
SGTC_310 1273-0058 1.06 µM -0.144482967688446 0.440270421687568 no 1899 0.442559552572407 2723 2734232
SGTC_2780 5215298 71.43 µM -0.145503630391566 0.439872127985102 no 1900 0.442156624808429 2734 2834131
SGTC_5 0352-0601 109.883 µM -0.146380518535179 0.439529988075885 no 1901 0.441810502802641 2685 762456
SGTC_1909 st060837 51.5 µM -0.147255521881177 0.439188628583835 no 1902 0.441465169038936 2714 678937
SGTC_1132 3456-3614 2.5 µM -0.147288851042157 0.439175626982568 no 1903 0.441452016041992 2932 3125502
SGTC_604 1000-0114 314 µM -0.147640705255229 0.439038373762163 no 1904 0.441313164481309 2758 1572745
SGTC_1091 telmisartan 47.6 µM -0.147721389095839 0.439006901199756 no 1905 0.441281325386359 2765 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2655 perillic acid 100 µM -0.148993558769679 0.438510713657519 no 1906 0.440779357795685 2656 5702197 An apoptosis inducer.
SGTC_3035 9091303 49.47 µM -0.149533401450135 0.438300186615469 no 1907 0.440566377548263 2669 25237002
SGTC_513 4245-1575 41.7 µM -0.152044773559092 0.437321035940729 no 1908 0.439575810975409 2801 719745
SGTC_957 1187-1561 14.1 µM -0.152144731297321 0.437282071646115 no 1909 0.439536392188077 2659 1538454
SGTC_3200 9114385 49.47 µM -0.15273046927748 0.437053758717652 no 1910 0.439305415820925 2811 17018030 YLR208W SEC13
SGTC_332 4112-0506 40.9 µM -0.153148932040015 0.436890660292745 no 1911 0.439140414399062 2683 2790355
SGTC_3161 9100388 49.47 µM -0.154687788958624 0.436290973841424 no 1912 0.438533728556959 2697 25236368
SGTC_2556 citropten 84.59 µM -0.155635425838674 0.435921756253219 no 1913 0.438160199701305 2682 2775 A potential DNA crosslinker.
SGTC_833 3852-0053 558 µM -0.15638863327333 0.435628331935704 no 1914 0.437863348135766 2840 3123681
SGTC_2457 5731572 11.68 µM -0.157271998014568 0.435284247862222 no 1915 0.437515243975212 2839 2865357
SGTC_1679 SEC14.276 6.7 µM -0.157377495309546 0.435243158322709 no 1916 0.437473674287497 2844 1005053 YMR079W SEC14
SGTC_2249 haloperidol 116.36 µM -0.157760766434827 0.435093886126583 no 1917 0.43732265763941 2671 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2603 homopterocarpin 100 µM -0.158818189608292 0.434682100677922 no 1918 0.436906058734152 2801 101795 A weak amylase inhibitor.
SGTC_2216 7189485 200 µM -0.159008595037288 0.43460795984069 no 1919 0.436831051064691 2778 731273
SGTC_301 4119-0100 24.5 µM -0.160615450751371 0.433982367697217 no 1920 0.436198142479554 2689 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_76 0433-0009 400.328 µM -0.161222044655022 0.433746247276473 no 1921 0.435959259555272 2840 2841569
SGTC_153 4077-0274 519.67 µM -0.163976165450848 0.432674487329031 no 1922 0.434874953517412 2826 3121976
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.164223125296944 0.432578407529839 no 1923 0.434777748447032 2895 165506
SGTC_2113 5491891 107.031 µM -0.165653828589254 0.432021870618088 no 1924 0.434214691682365 2712 789979
SGTC_1868 st057644 42.7 µM -0.167277677690832 0.431390364356586 no 1925 0.433575783640139 2686 688665
SGTC_1784 st039334 36.3 µM -0.167963910415098 0.431123544717211 no 1926 0.433305835490867 2945 3496984
SGTC_368 fentichlor 4.58 µM -0.168480536576361 0.430922691894906 no 1927 0.433102627179277 2791 7329 A pesticide.
SGTC_2713 st079149 53.4 µM -0.168881602564366 0.430766778626452 no 1928 0.432944885180212 2775 3103253
SGTC_1478 0453-0656 35.7 µM -0.170731474271018 0.430047786265422 no 1929 0.43221745664125 2718 5258496
SGTC_725 1497-0963 19 µM -0.17128517743013 0.429832622629176 no 1930 0.431999767462485 2812 3549977
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.171431491329776 0.429775769955848 no 1931 0.431942247392053 2928 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_917 harmaline 728.087 nM -0.171530605785523 0.429737258230381 no 1932 0.431903283557669 2813 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1560 lithocholic acid 53.1 µM -0.172281220894133 0.42944562237335 no 1933 0.431608223583572 2703 9903 A bile acid which acts as a detergent.
SGTC_1092 toremifene 6.32 µM -0.1726537178979 0.429300910710043 no 1934 0.4314618125534 2691 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1809 st050081 57.6 µM -0.173004581680658 0.429164612043085 no 1935 0.431323913134738 2855 5036894
SGTC_1057 3448-5381 134 µM -0.173655620536475 0.428911727937306 no 1936 0.431068058585884 2844 5497911
SGTC_116 0155-0182 31.788 µM -0.17397435979446 0.428787930150315 no 1937 0.430942806419943 2724 771486
SGTC_2612 dictamnine 15.46 µM -0.175741427160759 0.428101731591631 no 1938 0.430248543805797 2822 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2351 9026858 72.31 µM -0.176640245985651 0.427752779958818 no 1939 0.429895489702155 2716 1409300
SGTC_482 fipronil 114 µM -0.176644755597104 0.427751029318535 no 1940 0.429893718477545 2691 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_354 2783-3500 4.88 µM -0.178071485052627 0.427197241645148 no 1941 0.429333417867672 2743 6740761
SGTC_2676 harmalol 100 µM -0.178306599033925 0.427105995456386 no 1942 0.429241098290699 2745 5459187 A monoamine oxidase inhibitor
SGTC_86 0417-1630 471.922 µM -0.178707356505933 0.426950473110734 no 1943 0.429083746260458 2727 3634867
SGTC_591 4299-0174 154 µM -0.178922388324033 0.426867030181083 no 1944 0.428999321553606 2751 5509088
SGTC_3081 9117243 49.47 µM -0.179138506912644 0.426783168828415 no 1945 0.428914473437169 2915 45595589
SGTC_869 0564-0080 44.1 µM -0.181492068125306 0.425870122193345 no 1946 0.427990679244387 2763 6843321
SGTC_25 0118-0223 35.662 µM -0.18186250865373 0.425726448597246 no 1947 0.427845313773893 2843 5333628
SGTC_124 0136-0217 7.121 µM -0.181995645964179 0.425674814332703 no 1948 0.427793071428705 2803 3976905
SGTC_1318 1280-3875 124 µM -0.182112582014131 0.425629464408228 no 1949 0.427747187412766 2796 373245
SGTC_3249 9135183 49.47 µM -0.183483170533872 0.425097998778 no 1950 0.427209461291433 2907 4902779
SGTC_3206 9114350 49.47 µM -0.183507477760939 0.425088574522629 no 1951 0.427199925998923 2842 17087243
SGTC_1887 st057648 70.8 µM -0.185956305139225 0.42413934985035 no 1952 0.426239513520263 2879 688672
SGTC_1614 st002383 48.6 µM -0.186910097736951 0.423769755520748 no 1953 0.425865560937276 2748 1947235
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.187190044325972 0.423661289019246 no 1954 0.42575581517589 2753 689007
SGTC_234 nsc-17383 10.7 µM -0.188224402835409 0.42326057262527 no 1955 0.425350371834376 2839 408974
SGTC_3316 9136639 10.545 µM -0.18894587839797 0.422981115832832 no 1956 0.42506761768907 2833 4903665
SGTC_3075 9116269 49.47 µM -0.189659192933821 0.422704858231602 no 1957 0.424788099829527 2928 17015205 YNL244C SUI1
SGTC_1191 1487-1166 10.6 µM -0.190067430766944 0.422546770030752 no 1958 0.424628145657337 2862 3955771
SGTC_1007 4101-0031 70 µM -0.190636902493642 0.422326265598443 no 1959 0.42440503818013 2919 1146276
SGTC_763 3453-1109 128 µM -0.191413789696316 0.422025487348238 no 1960 0.424100708596544 2796 1560353
SGTC_2830 7992007 71.43 µM -0.191609979340526 0.421949538103929 no 1961 0.424023862488264 2646 1952075
SGTC_678 1218-2179 85.9 µM -0.191991636732423 0.421801798611167 no 1962 0.423874378241826 2732 6820081 YOR116C RPO31
SGTC_1997 st073024 93.8 µM -0.19296557659454 0.421424836626639 no 1963 0.423492963638851 2798 686268
SGTC_750 4073-0104 132 µM -0.193081143806456 0.421380111280284 no 1964 0.423447709925059 2820 22330957
SGTC_1651 st011928 86.1 µM -0.193119154902964 0.42136540093284 no 1965 0.423432825791804 2861 720198
SGTC_1065 prochlorperazine maleate 2.48 µM -0.193522674641093 0.421209245001557 no 1966 0.423274824947607 2751 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_345 1362-0200 395 µM -0.193988419414493 0.421029024347192 no 1967 0.423092474815885 2768 1419823
SGTC_738 1315-0003 72.4 µM -0.194655020838319 0.420771110701938 no 1968 0.422831513211896 2915 6251474
SGTC_925 2064-1272 59.6 µM -0.19538018535984 0.420490577125103 no 1969 0.422547663740229 2772 6815817
SGTC_2117 5521686 200 µM -0.196431052752445 0.42008411543116 no 1970 0.422136396547562 2739 803312
SGTC_1938 st074717 56.4 µM -0.197248645039738 0.419767940401935 no 1971 0.421816482530496 2706 17250979
SGTC_905 2-aminofluorene 215 µM -0.197382297662045 0.419716259875243 no 1972 0.421764190769163 2761 1539 An established DNA mutagen. YPR165W RHO1
SGTC_248 streptozotocin 5.23457 mM -0.197909891070411 0.419512264648373 no 1973 0.421557782645124 2843 5300 DNA alkylating agent.
SGTC_1085 doxorubicin 7.67 µM -0.200137757220992 0.418651094120019 no 1974 0.420686422348333 2850 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2894 9048625 32.47 µM -0.204162285555469 0.417096423324899 no 1975 0.419113341179629 2903 4092861
SGTC_1629 st005085 44.9 µM -0.204684516479126 0.416894780542511 no 1976 0.418909309175401 2772 24207091
SGTC_2619 obliquin 87.91 µM -0.204932658049958 0.416798976263026 no 1977 0.418812369622426 2782 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2849 9019321 12.99 µM -0.206200546417109 0.416309538059227 no 1978 0.418317130519942 2895 16489627
SGTC_1166 k206-0078 225 µM -0.206746593227926 0.416098789576921 no 1979 0.418103883653163 2760 5404595
SGTC_1786 berberine 21.6 µM -0.206892738496933 0.416042388440747 no 1980 0.418046813834958 2772 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2896 9052656 71.43 µM -0.207155126655588 0.415941130588571 no 1981 0.417944355427155 2850 6469436
SGTC_1569 carminic acid 40.6 µM -0.208187505029136 0.415542781105646 no 1982 0.417541282197609 2881 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_266 formosanin C 406 nM -0.208429483434604 0.415449424803308 no 1983 0.417446818676625 2904 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2281 7943571 200 µM -0.208496382672431 0.415423615633536 no 1984 0.417420703395055 2925 1244024
SGTC_3235 9132602 49.47 µM -0.209068180145774 0.415203035821183 no 1985 0.417197507175173 2872 4912240
SGTC_524 r073-0010 27.8 µM -0.209232293501776 0.415139731461998 no 1986 0.417133451864517 2764 2772106
SGTC_844 0330-0132 15.3 µM -0.209760329458576 0.414936064166031 no 1987 0.416927368352493 2903 2828079
SGTC_476 mead acid 10 µM -0.210209286249051 0.414762916256665 no 1988 0.416752166054101 2777 5312531 An omega 9 fatty acid.
SGTC_764 1951-2361 146 µM -0.214027634065551 0.413290977301244 no 1989 0.415262753793214 2798 5438930
SGTC_1452 4194-0072 190 µM -0.214198299599566 0.413225215544951 no 1990 0.415196211017541 2956 1343545
SGTC_1735 st034310 56.75 µM -0.214518480072409 0.413101848462177 no 1991 0.415071378682467 2990 871153
SGTC_702 1488-0190 94 µM -0.215615013098784 0.412679414074153 no 1992 0.414643926147247 2876 949357
SGTC_3037 9091026 49.47 µM -0.216249629442576 0.412434977160451 no 1993 0.414396584961967 2871 25236398 YIL048W NEO1
SGTC_2625 euphol 100 µM -0.216312336953385 0.41241082577896 no 1994 0.414372146603533 2923 6708538 A triterpene alcohol.
SGTC_2754 granisetron 64.02 µM -0.216775788243139 0.412232340880608 no 1995 0.414191540744951 2923 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_492 tmb-8 126 µM -0.216912231476941 0.412179797161075 no 1996 0.414138372598703 2877 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2959 9079155 11 µM -0.21792672937778 0.411789167682813 no 1997 0.413743100296203 2966 16189457
SGTC_3177 9107506 49.47 µM -0.217970426600066 0.411772344154624 no 1998 0.413726076788205 2909 8897194
SGTC_2991 9074669 71.4286 µM -0.218113581022266 0.411717230518426 no 1999 0.413670308007268 2987 17333109
SGTC_2012 4023501 200 µM -0.218575307355261 0.411539480386574 no 2000 0.413490444787306 2882 3477460
SGTC_2864 9034755 47.6 µM -0.21936906986288 0.411233949208808 no 2001 0.413181280954445 2765 4930451
SGTC_1714 st033236 13.627 µM -0.219406532699868 0.411219530525878 no 2002 0.413166690822719 2943 2916566
SGTC_1322 1348-1070 12 µM -0.219933709713202 0.411016643557172 no 2003 0.412961391226852 2783 6758089
SGTC_1141 3253-0389 52.6 µM -0.220224014838861 0.410904928193764 no 2004 0.412848347281737 2800 5402031
SGTC_2744 captopril 92.04 µM -0.221087728023026 0.410572596420469 no 2005 0.412512062730129 2877 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_845 0330-0138 4.51 µM -0.222077564304018 0.410191815092035 no 2006 0.412126751441244 2886 9039800
SGTC_3172 9105863 49.47 µM -0.222362208700404 0.410082330548818 no 2007 0.412015964235743 2830 2348785
SGTC_3343 9148379 18.9835 µM -0.223984276462992 0.409458558564374 no 2008 0.411384768997512 2951 1955036
SGTC_1947 st076332 61.6 µM -0.224053000730414 0.409432135449327 no 2009 0.411358031374749 2889 24208416
SGTC_362 0310-0100 9.03 µM -0.224675842490798 0.409192683945175 no 2010 0.411115729529111 2936 790235
SGTC_2468 5987765 72.9 µM -0.22503343969125 0.409055221011366 no 2011 0.410976630117148 2852 26772094
SGTC_2170 morpholine 200 µM -0.22532639687237 0.408942614498979 no 2012 0.410862682946636 2923 121171 Reacts with secondary amines.
SGTC_1248 0469-0687 58.6 µM -0.226137035945834 0.408631061268098 no 2013 0.410547420027982 2916 4017482
SGTC_1548 st061468 90.8 µM -0.226232395646766 0.408594415428453 no 2014 0.410510337802002 2927 390799
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.227068199403745 0.408273258109016 no 2015 0.410185355701455 2771 88881 An O-methylated flavonoid and antioxidant.
SGTC_987 1497-1013 404 µM -0.227553849750477 0.408086675405831 no 2016 0.409996550610088 2796 1676435
SGTC_2839 9003951 25.97 µM -0.22935256515853 0.407395806198233 no 2017 0.409297450513318 2807 2990634
SGTC_2999 9069765 71.4286 µM -0.229352595272568 0.407395794634126 no 2018 0.409297438811414 2892 2097066
SGTC_1120 ficusin 1.78878 µM -0.230307696644379 0.407029066334506 no 2019 0.408926340148087 2954 6199 A DNA cross-linker.
SGTC_194 1486-1323 56.904 µM -0.230375803516139 0.407002918588835 no 2020 0.408899880762958 2849 5178754
SGTC_1039 k821-0043 94 µM -0.23087772599409 0.406810232156028 no 2021 0.408704897682889 2978 15992768
SGTC_2665 lovastatin 100 µM -0.231094281792511 0.40672710404109 no 2022 0.408620778684687 2830 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2694 st077685 81.9 µM -0.232198591143097 0.406303264157064 no 2023 0.408191885981126 2786 2838096
SGTC_2220 6782180 200 µM -0.233709136308672 0.405723686626184 no 2024 0.407605397207256 2840 833803
SGTC_3198 9112019 49.47 µM -0.234564145803252 0.405395721523578 no 2025 0.407273520336699 2806 45595555
SGTC_1655 st012546 55.1 µM -0.234644405402665 0.405364938899934 no 2026 0.407242370523226 2916 720985 YLR208W SEC13
SGTC_3230 9131665 49.47 µM -0.234936230408715 0.405253017792443 no 2027 0.407129114319146 2811 15943720
SGTC_361 000s-0510 1.45 µM -0.235160849741435 0.405166876768832 no 2028 0.407041945675805 2909 660
SGTC_2833 9001315 45.46 µM -0.235230822245384 0.405140043404646 no 2029 0.407014792193764 2837 2989378
SGTC_3071 9117417 49.47 µM -0.236385848626349 0.404697173322814 no 2030 0.406566638118124 2892 45595590 YGL055W OLE1
SGTC_1788 fluconazole 20 µM -0.237560621744255 0.404246856982154 no 2031 0.406110947745167 2926 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_51 1013-0126 23.419 µM -0.238229352078454 0.403990574568561 no 2032 0.405851606348443 3082 1627850
SGTC_2277 7947813 106.88 µM -0.238783051095017 0.403778407625496 no 2033 0.405636906693364 3064 1246798
SGTC_2309 7664088 163.95 µM -0.239265141399028 0.40359370283175 no 2034 0.4054499967999 2980 704922
SGTC_1211 1056-0033 32.3 µM -0.239300664590646 0.403580093568166 no 2035 0.405436225054189 2915 6741922
SGTC_2768 sulfasalazine 50.2 µM -0.240767109138366 0.403018387157435 no 2036 0.404867811453497 2922 5384001 An antioxidant and salicylic acid derivative.
SGTC_252 miconazole 1.30953 nM -0.240962537370873 0.402943545478438 no 2037 0.404792075973058 2925 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_992 3909-8734 162 µM -0.241446741492707 0.402758128795769 no 2038 0.404604444802771 2880 4288319
SGTC_3051 9093778 49.47 µM -0.241699260947695 0.402661439986755 no 2039 0.404506601132659 2823 17217378
SGTC_78 0336-0123 156.75 µM -0.243699894210599 0.401895615451652 no 2040 0.403731627653564 2781 6765896
SGTC_2218 6965428 192.983 µM -0.244165959216978 0.4017172638996 no 2041 0.403551144950555 2843 675684
SGTC_1183 1254-0324 198 µM -0.244181144278852 0.401711453296063 no 2042 0.403545264912238 2978 5799357
SGTC_101 0490-5701 117.494 µM -0.245249836179091 0.401302570201745 no 2043 0.403131495334693 2803 4661669
SGTC_555 4296-0685 37 µM -0.246874462288803 0.400681192992455 no 2044 0.402502690421432 2868 2908540 YHR072W ERG7
SGTC_2460 5552655 174.22 µM -0.247006566138532 0.400630677731691 no 2045 0.402451571229075 2950 5401989
SGTC_660 4031-1742 102 µM -0.247855319175562 0.400306162283382 no 2046 0.402123175733888 2830 6738706
SGTC_1450 4112-4260 37.6 µM -0.247986176446468 0.400256135936378 no 2047 0.402072551200331 2990 1633175
SGTC_2346 9031566 143.75 µM -0.250833206509211 0.399168131247902 no 2048 0.400971533514919 2957 4771086
SGTC_155 k072-0202 43.6 µM -0.25102650735385 0.399094288790115 no 2049 0.400896807646878 2795 5857737
SGTC_1925 st057770 10.1 µM -0.251077047140573 0.399074982785552 no 2050 0.400877270671346 2852 5989122
SGTC_808 0711-0032 135 µM -0.251222889343379 0.399019273008044 no 2051 0.400820894388834 2848 4252555
SGTC_767 0929-0023 86 µM -0.252460277950752 0.398546689919599 no 2052 0.400342656735538 2874 1204563
SGTC_2124 5246320 200 µM -0.253413468530974 0.39818274903255 no 2053 0.399974360440656 2944 579342
SGTC_6 0844-0013 19.835 µM -0.255227523155809 0.397490363651731 no 2054 0.399273687214587 2913 1584900
SGTC_2984 9022109 38.96 µM -0.255601123859692 0.397347808370822 no 2055 0.399129425254604 2956 6459207
SGTC_1830 st055982 50.3 µM -0.256236789986364 0.39710528798319 no 2056 0.398884001172329 2903 455313 An antimicrobial agent.
SGTC_1462 k081-0014 26.5 µM -0.257079410719043 0.396783871265026 no 2057 0.398558735694493 2884 3270634
SGTC_292 k038-0015 474 µM -0.257192040474818 0.396740914080387 no 2058 0.398515264087278 2977 46368540
SGTC_405 ebelactone b 50 µM -0.258113689536773 0.396389442652664 no 2059 0.398159583372977 2847 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_974 1326-0144 138 µM -0.258870427727676 0.396100923008729 no 2060 0.397867607925397 2882 5411856
SGTC_3134 9127454 49.47 µM -0.259049550998543 0.396032637458146 no 2061 0.397798504412981 2921 24262820
SGTC_3317 9138495 8.753 µM -0.260524868098949 0.395470337139494 no 2062 0.397229467722695 2864 17020139
SGTC_1293 1000-1278 195 µM -0.261163150201946 0.3952271305297 no 2063 0.396983347037527 3005 678847
SGTC_587 k089-0003 57 µM -0.261732583844478 0.39501019190083 no 2064 0.396763808844413 2855 9659696
SGTC_1690 st023502 41.2 µM -0.261903345138469 0.394945142862208 no 2065 0.396697980284717 2948 24207482
SGTC_2647 atorvastatin 60.16 µM -0.262294589961061 0.394796114863579 no 2066 0.396547166323058 2939 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3052 9092717 49.47 µM -0.262577341740404 0.394688422234463 no 2067 0.3964381830346 3039 25237534
SGTC_1164 k060-0068 93.7 µM -0.263047021788742 0.394509551390587 no 2068 0.396257168369349 2885 5963676
SGTC_686 1319-0111 510 µM -0.265288319044969 0.393656292690235 no 2069 0.395393681144805 3040 4562600
SGTC_3279 9140807 49.47 µM -0.265331383497397 0.393639903098438 no 2070 0.39537709504978 2838 45595718
SGTC_3207 9114163 49.47 µM -0.266160856506406 0.393324256701677 no 2071 0.395057663978807 3153 849233
SGTC_3226 9131256 49.47 µM -0.26687095450522 0.393054092777549 no 2072 0.394784260384653 2879 17178073
SGTC_1974 st069448 26.9 µM -0.267198691425213 0.392929419333191 no 2073 0.394658091813681 3013 6323587 YNR016C ACC1
SGTC_1 0258-0098 57.368 µM -0.268579235092044 0.392404371460941 no 2074 0.394126746665424 2932 6790032 YDR047W HEM12
SGTC_2727 riluzole 51.77 µM -0.269316095463181 0.392124209067606 no 2075 0.39384322361088 2882 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_439 amiodarone 34.4 µM -0.269661194711024 0.391993017765959 no 2076 0.3937104585047 2931 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2815 7968870 71.43 µM -0.271038595528552 0.391469514012843 no 2077 0.393180673963812 2882 2977326 YHR190W ERG9
SGTC_861 0443-0273 110 µM -0.27171766373027 0.391211495275389 no 2078 0.392919559212409 2978 6149169
SGTC_1699 st031318 29.054 µM -0.272242747860934 0.391012017132715 no 2079 0.392717687312248 2989 5340658
SGTC_3122 9126309 49.47 µM -0.272805459285934 0.390798276301706 no 2080 0.392501381394581 2945 17591206
SGTC_3312 9133330 71.43 µM -0.273187477670223 0.390653188878525 no 2081 0.39235455268607 3038 17617324
SGTC_2297 7971671 152.32 µM -0.274296013123133 0.390232262525009 no 2082 0.391928574065239 3055 909016
SGTC_2160 5660466 132.927 µM -0.274941331441412 0.389987285382873 no 2083 0.391680656211855 2911 2859134
SGTC_183 3914-0051 30.55 µM -0.275710792361075 0.389695238067333 no 2084 0.391385102853835 3034 1596232
SGTC_1216 1165-0504 9.65 µM -0.276994083464411 0.389208306162542 no 2085 0.390892324591843 3020 6304004
SGTC_1720 st037298 9.481 µM -0.277648129153601 0.388960201967843 no 2086 0.390641241189924 2982 597396
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.278033286074144 0.388814118597658 no 2087 0.39049340356113 2899 165521
SGTC_867 0518-0118 155 µM -0.278086171442543 0.388794061317473 no 2088 0.390473105414739 2973 6848158
SGTC_1262 0737-0114 49.6 µM -0.279791896321821 0.38814730813824 no 2089 0.389818584649847 3051 765919
SGTC_1555 citronellol 128 µM -0.280497654432849 0.387879799122126 no 2090 0.389547862380252 2989 8842 A terpine precursor.
SGTC_2038 4100038 30.985 µM -0.283073053211959 0.386904077757643 no 2091 0.388560418775192 3005 3596803
SGTC_1654 st012436 41.8 µM -0.283206246322226 0.386853635291308 no 2092 0.388509370208507 2964 4323132
SGTC_2266 7929956 200 µM -0.284551016799299 0.386344455335624 no 2093 0.387994071634901 2861 2967153
SGTC_1412 3909-8563 178 µM -0.2855321197062 0.385973096793852 no 2094 0.387618250082448 3005 23767530
SGTC_1010 4112-3296 15.2 µM -0.285586744726549 0.385952423672991 no 2095 0.387597328497514 3070 704384
SGTC_1875 nocodazole 6 µM -0.286234157045327 0.385707431820804 no 2096 0.387349392056475 2974 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1952 st077036 64.1 µM -0.28774441935878 0.385136100190659 no 2097 0.386771192775482 2872 2937007
SGTC_3319 9138450 16.7555 µM -0.289199388439866 0.384585921667376 no 2098 0.38621439990999 2921 2029690
SGTC_2918 7977171 22.06 µM -0.289538376437503 0.384457770894521 no 2099 0.386084708353499 2881 2236483
SGTC_959 1222-0044 107 µM -0.289860810873526 0.384335889734172 no 2100 0.385961361744469 3054 6083612
SGTC_835 0312-0010 67.2 µM -0.292971076381691 0.383160789084195 no 2101 0.384772129927404 2898 1626196
SGTC_1451 4152-0210 104 µM -0.29309906382862 0.383112456624604 no 2102 0.384723216161008 3089 659563
SGTC_1421 4029-0249 71.4 µM -0.295065774035213 0.38236998847259 no 2103 0.383971817339358 3078 2894095
SGTC_3255 9139072 49.47 µM -0.295155459239263 0.38233614099443 no 2104 0.383937562695773 2992 17646060
SGTC_3145 9085516 49.47 µM -0.295796302756535 0.382094310812408 no 2105 0.383692823348055 3015 25236195
SGTC_2750 bromebric acid 70.15 µM -0.296175916790549 0.381951080473337 no 2106 0.38354786990488 3078 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2516 gossypol 71.55 µM -0.296673289967578 0.381763443454707 no 2107 0.383357975474492 3076 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2273 7815444 169.05 µM -0.296768636053 0.381727476742683 no 2108 0.383321576045849 3117 2824616
SGTC_3215 9129942 49.47 µM -0.297156315903844 0.381581245604247 no 2109 0.383173585561413 3064 17682944
SGTC_3211 9128781 49.47 µM -0.297922235430928 0.381292393813886 no 2110 0.382881258355695 3042 17194361
SGTC_2191 5911152 200 µM -0.298667175760349 0.381011517344368 no 2111 0.38259700222497 2982 2875902
SGTC_3232 9132874 49.47 µM -0.299422145151525 0.380726923413383 no 2112 0.382308983700935 2933 3784940
SGTC_287 k060-0039 29.6 µM -0.300789820680711 0.380211527651749 no 2113 0.381787385542934 3078 5861974
SGTC_3074 9116018 49.47 µM -0.302047485635919 0.379737775970428 no 2114 0.381307932061386 2899 17027303
SGTC_899 1083-0020 478 µM -0.303201777636843 0.379303122791554 no 2115 0.380868047192383 3111 767123
SGTC_802 4112-3352 742 µM -0.303540075722621 0.379175764197359 no 2116 0.380739155569276 3086 704594
SGTC_2154 5570129 200 µM -0.304939910876096 0.378648909803875 no 2117 0.380205958993053 2956 673366
SGTC_512 prima-1 270 µM -0.30529979562478 0.378513496775441 no 2118 0.380068915788594 3095 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_27 0485-0001 32.618 µM -0.305781343266656 0.378332329257406 no 2119 0.379885567216009 2921 2054479
SGTC_1756 st041558 35.5 µM -0.305954666682208 0.37826712818595 no 2120 0.379819581179557 3140 3955792
SGTC_561 1550-0330 72.9 µM -0.306052873565636 0.378230186106438 no 2121 0.379782194345134 2951 6812934
SGTC_929 2805-0021 398 µM -0.30638780859047 0.378104203349303 no 2122 0.37965469482879 3021 3098024
SGTC_2213 7173844 200 µM -0.308127096181558 0.377450194847335 no 2123 0.378992811923818 2983 892728
SGTC_2008 4012253 172 µM -0.308491328137487 0.377313280436109 no 2124 0.378854248925614 2915 603940
SGTC_307 1501-1223 22.3 µM -0.309495706491864 0.376935815595033 no 2125 0.378472238840853 3040 2830329
SGTC_1119 parthenolide 318.541 nM -0.310187834085785 0.376675769050464 no 2126 0.378209060787951 3154 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2356 9061756 188.97 µM -0.31026533792582 0.37664665274801 no 2127 0.378179593856017 3018 20104043
SGTC_820 1582-0060 59.9 µM -0.31237612647552 0.375853951275212 no 2128 0.377377345783904 2997 3848840
SGTC_64 000l-0018 272.079 µM -0.312752426985321 0.37571268744076 no 2129 0.377234380575855 2899 6811119
SGTC_916 4466-0038 42 nM -0.314294886077203 0.375133820015897 no 2130 0.376648540953242 3167 5722064 YGL116W CDC20
SGTC_2429 5902844 64.44 µM -0.315189150334818 0.374798341418888 no 2131 0.376309021417024 3112 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1797 st048695 56.8 µM -0.315236442553764 0.374780602623253 no 2132 0.376291068947366 3082 592262 YIL048W NEO1
SGTC_2048 5246248 200 µM -0.315442464672808 0.374703329064481 no 2133 0.376212864578275 3081 677046
SGTC_2779 methotrexate 400 µM -0.31774169032407 0.37384129112266 no 2134 0.375340442214559 3058 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_862 0452-0056 10.2 µM -0.319532012294726 0.373170490532033 no 2135 0.374661560179018 3043 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1546 5-methoxyflavanone 78.7 µM -0.322198091652621 0.372172272491025 no 2136 0.373651315055158 3028 147795
SGTC_2639 lactacystin 53 µM -0.322619796237208 0.37201445874917 no 2137 0.373491599775331 3119 3870 A proteasome inhibitor.
SGTC_355 1311-2252 105 µM -0.323626927077984 0.371637649024654 no 2138 0.373110249659993 2992 5338538
SGTC_236 1509-0011 5.31 µM -0.324108640576182 0.371457463325799 no 2139 0.372927892747807 3104 3107280
SGTC_2271 7849410 118.62 µM -0.324247525877621 0.371405518287266 no 2140 0.37287532177213 3108 972430
SGTC_986 1493-0483 84 µM -0.324342922924333 0.371369839818907 no 2141 0.372839213376968 3085 40079
SGTC_683 panaxydol 45 µM -0.32516106191239 0.371063901484113 no 2142 0.372529588420326 2986 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1492 4158-0558 28.5 µM -0.325495161340329 0.370938990356189 no 2143 0.372403172059577 3079 3967268
SGTC_2770 toltrazuril 17.5 µM -0.325573126779333 0.370909843053138 no 2144 0.372373673516765 3025 68591 Kills coccidiodes.
SGTC_374 0880-0231 82.3 µM -0.326911812574993 0.37040949234902 no 2145 0.371867293206774 3048 6833587
SGTC_2119 5528445 120.635 µM -0.327573463511765 0.370162272839549 no 2146 0.371617094429892 3126 791935
SGTC_480 am 92016 50 µM -0.331834357472694 0.368571519570661 no 2147 0.370007169667434 3058 2129 K+ channel blocker.
SGTC_3104 9120930 49.47 µM -0.332038742437268 0.368495271244633 no 2148 0.369930002364867 3086 17014836
SGTC_2052 5265182 7.135 µM -0.333573296450325 0.367922952559712 no 2149 0.369350785748684 3155 1239884
SGTC_2096 5468907 200 µM -0.333915259310487 0.367795455890969 no 2150 0.369221752388616 3107 759785
SGTC_537 1334-0398 209 µM -0.333990777844402 0.367767301692568 no 2151 0.369193258852298 3159 5846986
SGTC_775 4577-0580 57.3 µM -0.334206153083828 0.367687011171145 no 2152 0.369112000600285 3190 2006902
SGTC_1716 st033144 30.6155 µM -0.334577110790349 0.367548734052117 no 2153 0.368972056838907 3164 674617
SGTC_765 1319-0117 244 µM -0.335119384017771 0.367346628755669 no 2154 0.368767515568669 3003 3487746 YGL099W LSG1
SGTC_584 0986-0246 15.4 µM -0.336347427453605 0.366889072720161 no 2155 0.368304444549962 3070 53315 YDR232W HEM1
SGTC_2736 butenafine 14.65 µM -0.337650269133197 0.366403854310851 no 2156 0.367813377656652 3011 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1750 st081859 2.357 µM -0.338858016796868 0.365954242496223 no 2157 0.367358346474257 3033 5291695
SGTC_2653 dihydrofissinolide 100 µM -0.339330881686701 0.365778257772623 no 2158 0.367180240517066 3065 6857746
SGTC_2970 9090938 41.86 µM -0.340695845305738 0.365270421851463 no 2159 0.366666283360495 3210 17217104
SGTC_2892 9047358 58.44 µM -0.340729397557873 0.365257941676634 no 2160 0.366653652754568 3040 6466771
SGTC_550 4123-0385 25.7 µM -0.341701849254531 0.364896288299903 no 2161 0.366287640144639 3004 5731123
SGTC_3123 9126162 49.47 µM -0.341728620946461 0.364886333644668 no 2162 0.366277565499616 2981 25239884
SGTC_2914 7968218 45.32 µM -0.3420419520228 0.364769832919233 no 2163 0.366159660516528 3097 2977111
SGTC_2927 9011802 47.9 µM -0.342406649213698 0.364634249302874 no 2164 0.366022442623668 3104 43912568
SGTC_23 0213-0011 39.996 µM -0.344147134021883 0.363987422057108 no 2165 0.365367818756507 3178 627608
SGTC_3091 9116372 49.47 µM -0.344532703845095 0.363844182676031 no 2166 0.365222852823242 3173 17169793
SGTC_1409 3909-8004 61.9 µM -0.344575918033219 0.363828129768933 no 2167 0.365206606420732 3052 2119279
SGTC_454 lyso-paf C-16 6.67 µM -0.344929296165091 0.363696868280319 no 2168 0.36507376275903 3078 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3032 9089427 49.47 µM -0.345761657285799 0.363387752908745 no 2169 0.364760921444957 3113 17173707
SGTC_1772 st048439 82.2 µM -0.347502596835892 0.362741504960555 no 2170 0.364106883965586 3105 2927068 YDL195W SEC31
SGTC_2441 5730946 39.09 µM -0.347966518730276 0.362569360036914 no 2171 0.363932664116082 3153 1774275
SGTC_2208 7283366 200 µM -0.347994711443071 0.362558899618393 no 2172 0.363922077614589 3099 898663
SGTC_1988 st071872 53.4 µM -0.348813669690189 0.362255084127682 no 2173 0.363614600148216 3145 16414116
SGTC_1324 1418-0026 34.4 µM -0.351391268191923 0.361299418774196 no 2174 0.362647416120066 3127 1372513
SGTC_1403 3909-7815 62.9 µM -0.35288264314281 0.360746874090149 no 2175 0.362088211793975 2994 6615483
SGTC_575 k072-0246 11.9 µM -0.353398773503914 0.360555718780225 no 2176 0.361894752591849 3045 6796779
SGTC_669 0108-0021 26.2 µM -0.353470014674993 0.360529336460351 no 2177 0.361868052301818 3330 17201
SGTC_3287 9117173 37.0625 µM -0.35463297844831 0.360098756953564 no 2178 0.361432283344236 3072 2789709
SGTC_2487 5918373 44.05 µM -0.35504603381396 0.359945868657624 no 2179 0.361277552431054 3163 2876279
SGTC_384 k007-0144 5.16 µM -0.355857830063528 0.359645455730906 no 2180 0.360973518962478 3081 6824886
SGTC_2993 9054257 71.4286 µM -0.356977809063868 0.359231139204398 no 2181 0.360554209255421 2994 6470217 YGL055W OLE1
SGTC_598 3937-0236 20.2 µM -0.357352845049023 0.359092438200503 no 2182 0.360413836712666 3096 1379313
SGTC_1919 st067113 52.3 µM -0.35745094493142 0.359056160606436 no 2183 0.360377121926126 3163 1268243
SGTC_3225 9130819 49.47 µM -0.358255317090477 0.35875874963266 no 2184 0.360076126804293 3163 4547121
SGTC_2227 7312221 64.1025 µM -0.358385869672858 0.358710486800454 no 2185 0.360027282356288 3043 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2946 9065502 71.43 µM -0.358971846854779 0.358493889864095 no 2186 0.359808075234871 3066 16489101
SGTC_2971 9092186 9.93 µM -0.3589899255273 0.358487208100199 no 2187 0.359801312950496 2992 25236400
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.360418660801737 0.357959293662604 no 2188 0.359267036868983 3057 4330530
SGTC_29 0299-0004 12.984 µM -0.36091425802319 0.357776234989678 no 2189 0.359081772309697 3073 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.36208700079399 0.357343189495811 no 2190 0.358643508691515 3100 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1502 4534-4282 27.7 µM -0.362281743001491 0.357271297003139 no 2191 0.358570749926731 3087 3278949
SGTC_954 1189-0853 2.85 µM -0.36288081084367 0.357050172402016 no 2192 0.358346960911123 3053 2828194
SGTC_24 0417-1663 219 µM -0.364296392501015 0.356527851620723 no 2193 0.357818346719392 3145 4329390
SGTC_1424 4048-1941 275 µM -0.367412314168835 0.355379088815725 no 2194 0.356655743783607 3192 X1424
SGTC_2404 5161160 200 µM -0.370000463225686 0.35442590010543 no 2195 0.355691072625517 2993 2831543
SGTC_1687 st020778 55.3625 µM -0.370131079920127 0.354377819419457 no 2196 0.355642412779835 3075 4259299
SGTC_1186 1319-0216 26 µM -0.370695377303562 0.354170125291563 no 2197 0.355432216898648 3203 4565136
SGTC_3195 9113082 49.47 µM -0.371020402717948 0.354050516791275 no 2198 0.355311167701243 3154 17018038
SGTC_1430 4049-0248 69.1 µM -0.371703518155906 0.35379917904897 no 2199 0.355056802646516 3168 22774488
SGTC_1759 st043059 70 µM -0.372006775944609 0.353687622231445 no 2200 0.354943902183768 3037 669426
SGTC_2788 5282734 71.43 µM -0.372398096656244 0.353543689035567 no 2201 0.354798235417142 3211 743706
SGTC_3098 9119039 49.47 µM -0.373131026417784 0.353274163631393 no 2202 0.354525463872407 3064 17161528
SGTC_2667 digitoxin 100 µM -0.37348628184532 0.353143549525505 no 2203 0.354393276707853 3145 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1167 k781-0610 148 µM -0.374688314817334 0.352701735424031 no 2204 0.353946141821931 3094 4525169
SGTC_2853 9015042 58.44 µM -0.380945162946818 0.350405214225257 no 2205 0.351621969723335 2975 6457456
SGTC_2499 avocadenofuran 51.48 µM -0.383260581715087 0.349556739119964 no 2206 0.350763281573821 3035 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_694 1315-0438 43.2 µM -0.383354500298463 0.349522338886558 no 2207 0.350728467302308 3104 6793154
SGTC_2009 4012297 12.05 µM -0.383938600393743 0.349308424104615 no 2208 0.350511977924922 3169 45595307
SGTC_1054 3429-0080 167 µM -0.385001728033211 0.348919198092841 no 2209 0.350118067624699 3242 1162877
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.385066992791611 0.348895308918355 no 2210 0.35009389095901 3059 3256 An antibiotic and ribosome inhibitor.
SGTC_3346 9158254 43.5805 µM -0.386858524723 0.348239780012638 no 2211 0.349430473736052 3167 17639500
SGTC_3084 9116877 49.47 µM -0.387321750945327 0.348070357280502 no 2212 0.34925901243219 3149 27241325
SGTC_3022 9087993 49.47 µM -0.387383449048358 0.348047793787662 no 2213 0.349236177450753 3170 17173644
SGTC_2398 5228213 48.84 µM -0.389074825375853 0.347429453612003 no 2214 0.348610397805016 3283 80771 YMR134W ERG29
SGTC_2861 9024595 19.48 µM -0.3891601060302 0.347398287099239 no 2215 0.348578856344136 3120 16482810
SGTC_1835 st008666 49.2 µM -0.389224628296819 0.347374707594652 no 2216 0.348554993168546 3063 690455
SGTC_3150 9097574 49.47 µM -0.390361952303399 0.346959172357125 no 2217 0.348134459124977 3247 17217476
SGTC_2246 7293507 91.5585 µM -0.390568818699407 0.346883610949679 no 2218 0.348057988780512 3219 887656
SGTC_2321 7390090 138.78 µM -0.392743770961417 0.346089542352595 no 2219 0.347254369224565 3128 649046
SGTC_283 0987-0079 11.7 µM -0.393735473516043 0.345727698959674 no 2220 0.34688817423493 3204 411556
SGTC_2778 tioconazole 65.09 nM -0.395861420585869 0.344952477831647 no 2221 0.346103631485772 3115 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1224 0823-0416 294 µM -0.396948137938561 0.344556460122098 no 2222 0.345702852595663 3235 3598164
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.397108818773993 0.344497919820423 no 2223 0.345643608526978 3279 551469
SGTC_3101 9120531 49.47 µM -0.399611874443565 0.343586471749038 no 2224 0.344721204535134 3303 24824904
SGTC_1087 pterostilbene 9.05 µM -0.403602080597096 0.34213538174009 no 2225 0.343252677729397 3230 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2221 6807166 181.081 µM -0.403671072939171 0.342110312199593 no 2226 0.343227307009793 3168 674925
SGTC_728 3030-5151 22.5 µM -0.403798409286007 0.342064044200669 no 2227 0.343180483164801 3105 3125388
SGTC_1291 0993-0025 5.79 µM -0.40398485578537 0.341996302649401 no 2228 0.343111927806353 3226 4353356
SGTC_1942 st076330 65.2 µM -0.405734397778465 0.34136089010704 no 2229 0.342468882607229 3248 24208414
SGTC_2467 5474540 200 µM -0.405836432461782 0.341323846194837 no 2230 0.342431393764822 3108 5413519
SGTC_1726 st035556 14.5795 µM -0.406641119867829 0.341031756292113 no 2231 0.342135795783734 3292 5919439
SGTC_3197 9113331 49.47 µM -0.407042184335066 0.340886211240087 no 2232 0.341988502816647 3318 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2560 caryophyllene 100 µM -0.41105100785603 0.339432725943679 no 2233 0.340517566479128 3114 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1591 genipin 88.4 µM -0.41118318249903 0.339384843685496 no 2234 0.340469109472944 3246 442424 A DNA cross-linking agent.
SGTC_2624 nerol 100 µM -0.413480204158432 0.338553127636755 no 2235 0.339627411537191 3120 637566 A natural product oil.
SGTC_3253 9135987 49.47 µM -0.41521112672843 0.337926906897309 no 2236 0.338993677085389 3231 4182430
SGTC_2687 chenodiol 100 µM -0.416681446715043 0.337395320129443 no 2237 0.338455713394066 3243 5702181 A cholesterol synthesis inhibitor.
SGTC_107 0358-0022 2.6945 µM -0.418284860367417 0.336815983774068 no 2238 0.337869428725117 3195 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3028 9087778 49.47 µM -0.418448192467093 0.336756991238144 no 2239 0.337809728741853 3134 17217395
SGTC_605 1315-0399 119 µM -0.419079090385404 0.33652916029953 no 2240 0.337579165767842 3276 24020461
SGTC_3040 9091894 49.47 µM -0.419477905813698 0.336385170333822 no 2241 0.337433449267434 3106 25236966
SGTC_2836 9010338 19.48 µM -0.419896489116047 0.336234069100273 no 2242 0.33728053633217 3127 2994051
SGTC_647 0140-0236 81 µM -0.420143308630536 0.336144983978734 no 2243 0.33719038313032 3186 990837
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.420558924316332 0.335994995670752 no 2244 0.337038596629841 3195 97141
SGTC_2677 mitomycin C 100 µM -0.424351390429052 0.334627570918441 no 2245 0.335654782856469 3171 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_395 anisomycin 6.25 µM -0.424779241866589 0.334473440491052 no 2246 0.335498805689107 3207 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1456 k015-0012 13 µM -0.425399430746928 0.334250071401451 no 2247 0.335272760471064 3332 2989616
SGTC_1265 0819-1001 68.8 µM -0.426009586424169 0.334030373164096 no 2248 0.335050430324694 3232 3106768
SGTC_2337 9009472 200 µM -0.427989143684448 0.333317987497946 no 2249 0.334329512182465 3348 5742383
SGTC_132 0417-1715 25.805 µM -0.428921375584886 0.332982712011058 no 2250 0.333990221881341 3325 6769098
SGTC_2803 7707263 71.43 µM -0.43004946289076 0.332577175978068 no 2251 0.333579830460699 3120 2199229
SGTC_1864 st057645 30.4 µM -0.430506169140941 0.332413050348004 no 2252 0.333413740036214 3267 688666
SGTC_403 arphamenine a 50 µM -0.430944532559448 0.332255546762312 no 2253 0.333254351063292 3188 5487158 An arginine aminopeptidase inhibitor.
SGTC_1892 st058411 7.36 µM -0.432953398692981 0.331534142232961 no 2254 0.332524312685718 3266 3934738
SGTC_2741 miltefosine 3.04 µM -0.434545430337783 0.330962870646015 no 2255 0.331946206047203 3165 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2361 9034121 116 µM -0.436391808934984 0.33030082393648 no 2256 0.331276240441061 3180 6496917
SGTC_265 mycophenolic acid 32.932 µM -0.438081381576292 0.329695467402396 no 2257 0.330663645245633 3404 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2314 7727897 200 µM -0.439193194516744 0.329297359370762 no 2258 0.33026077790362 3160 900724
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.439831524012177 0.329068879444245 no 2259 0.330029566953757 3162 688803
SGTC_3170 9103054 49.47 µM -0.443747104698268 0.327668758953404 no 2260 0.328612717523762 3247 16432970
SGTC_1659 st012954 42.1 µM -0.444256700106653 0.327486717031833 no 2261 0.328428501390156 3279 24207262
SGTC_1363 1636-0063 10.4 µM -0.445156936086715 0.327165227461305 no 2262 0.328103172613424 3202 6072185
SGTC_617 3770-0098 35 µM -0.44556100311961 0.327020969922124 no 2263 0.327957192567204 3212 5962639
SGTC_2295 7971645 200 µM -0.446697860145843 0.326615234880944 no 2264 0.327546613538663 3192 2978226 YKL099C UTP11
SGTC_1647 st011722 22.4 µM -0.447767495247628 0.326233677945512 no 2265 0.327160502212519 3310 2854783
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.447923230541416 0.326178139684718 no 2266 0.327104301105039 3131 688667
SGTC_1672 st016598 6.51 µM -0.448885460614343 0.325835075092466 no 2267 0.326757142486126 3197 4665860 YNL267W PIK1
SGTC_3256 9138902 49.47 µM -0.448993092362885 0.3257967102281 no 2268 0.326718319833981 3216 17228773
SGTC_2818 7996756 12.99 µM -0.449378028837231 0.325659516409774 no 2269 0.326579489031005 3129 2241621
SGTC_1558 st069300 45.6 µM -0.449918128192147 0.325467061357603 no 2270 0.326384737825828 3288 24208000
SGTC_1036 k216-0215 33.5 µM -0.450228420371539 0.325356515152481 no 2271 0.326272872818207 3206 622330
SGTC_109 0132-0036 33.701 µM -0.451792412970136 0.324799553581058 no 2272 0.325709267973284 3200 67274 A color developer.
SGTC_1044 1222-0021 1.78 µM -0.452440322799475 0.324568937624162 no 2273 0.325475901892618 3247 4306703
SGTC_1195 1502-0147 41.1 µM -0.453701858482311 0.324120101694852 no 2274 0.325021714550289 3221 817940
SGTC_327 1273-0057 3.96 µM -0.45405068865741 0.323996038091707 no 2275 0.324896171990063 3220 3108138
SGTC_1152 3909-8331 15.9 µM -0.454761029820133 0.323743461316884 no 2276 0.324640584577885 3220 16001939
SGTC_1914 st062367 72.6 µM -0.456737178628432 0.323041227170875 no 2277 0.323929982293583 3182 978205
SGTC_940 3232-1287 54.8 µM -0.461298980162141 0.321422578646688 no 2278 0.322292058267087 3314 1585493 YIL048W NEO1
SGTC_3188 9110789 49.47 µM -0.462113768909519 0.321133825379639 no 2279 0.321999868367816 3354 849217
SGTC_1042 0350-0096 82 µM -0.462179795769268 0.321110430831123 no 2280 0.321976195412573 3204 3122515
SGTC_16 erodoxin 22.806 µM -0.463441421505226 0.320663549775112 no 2281 0.321523997013357 3338 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_263 alizarin 107.927 µM -0.4645844123357 0.320258914707001 no 2282 0.321114548538039 3263 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3025 9087895 49.47 µM -0.464741453833652 0.320203336457321 no 2283 0.3210583092418 3332 17173641
SGTC_3262 9137218 49.47 µM -0.46494776495997 0.320130327420212 no 2284 0.320984431871441 3226 17650664
SGTC_1739 st037196 92.5 µM -0.467629978951893 0.319181784668448 no 2285 0.320024611239763 3364 612214
SGTC_2635 hydroquinidine 100 µM -0.468124896627782 0.319006890180102 no 2286 0.319847638050532 3224 442912 An experimental heart treatment.
SGTC_1917 st066507 28.5 µM -0.470249409648325 0.318256585747491 no 2287 0.319088418562535 3183 3156428
SGTC_1931 st074438 57.1 µM -0.470269331259164 0.318249553645629 no 2288 0.319081302926342 3286 2787313
SGTC_81 0411-0046 9.971 µM -0.470370780610165 0.318213744195644 no 2289 0.319045068101885 3260 12925265
SGTC_1776 st049249 45.9 µM -0.471828007113229 0.31769956202784 no 2290 0.318524779151461 3282 1822314
SGTC_3109 9122853 49.47 µM -0.472680142628369 0.317399048882659 no 2291 0.31822069786444 3275 1234709
SGTC_771 0250-0039 27.3 µM -0.475279407563733 0.316483138963247 no 2292 0.31729391731847 3228 3005115
SGTC_2077 5212015 200 µM -0.475737289483509 0.316321910209009 no 2293 0.317130775691761 3233 780900
SGTC_2201 6605497 169.863 µM -0.476118503576499 0.316187704254173 no 2294 0.316994977632763 3279 670741
SGTC_2428 5615643 7.78 µM -0.476707196548739 0.315980503183235 no 2295 0.316785318794076 3307 2253075
SGTC_857 0438-0306 1.35 µM -0.477455401405369 0.315717242449042 no 2296 0.316518935832428 3337 4686136
SGTC_624 k048-0052 28 µM -0.477983750788973 0.315531395587962 no 2297 0.316330885201999 3252 6835531
SGTC_1815 st051655 58.2 µM -0.478513456355206 0.31534511851623 no 2298 0.316142399545502 3318 5984156
SGTC_609 0986-0026 86.3 µM -0.478757020387214 0.315259482161995 no 2299 0.316055747944533 3244 2848610
SGTC_387 norethindrone acetate 66.7 µM -0.479424348133744 0.315024902667804 no 2300 0.315818387746579 3265 541197
SGTC_790 1575-0012 79.1 µM -0.479788294305295 0.314896999492362 no 2301 0.31568896860106 3360 378741 YLR208W SEC13
SGTC_801 0866-0028 10.1 µM -0.481177670413189 0.314408929266125 no 2302 0.315195114792705 3217 6849771
SGTC_1519 esterone 74 µM -0.482714604579026 0.313869401461343 no 2303 0.314649195984791 3203 698 A steroid.
SGTC_1315 1237-0019 3.69 µM -0.483239309589403 0.313685299190994 no 2304 0.314462913490667 3348 825140
SGTC_731 3966-0296 387 µM -0.484175831611932 0.313356818761258 no 2305 0.31413054376884 3260 660956
SGTC_426 0988-0037 14.6 µM -0.48464358004733 0.313192813731831 no 2306 0.313964597227153 3398 5383008
SGTC_1234 0326-0494 15.5 µM -0.484780653943347 0.313144758980145 no 2307 0.313915973641464 3405 1547813
SGTC_182 3448-4371 550.524 µM -0.485311977676845 0.312958519884285 no 2308 0.313727530184915 3373 3491403
SGTC_2982 9019404 25.97 µM -0.487749105356124 0.312104872202128 no 2309 0.312863782462499 3227 22333232
SGTC_1018 4259-0013 28.1 µM -0.487976062920519 0.312025427479233 no 2310 0.312783398107019 3343 6801262
SGTC_968 1309-0633 340 µM -0.488377790282275 0.311884827388454 no 2311 0.312641135206239 3347 3761976
SGTC_46 0329-0187a 2.197 µM -0.488650576454385 0.311789370897334 no 2312 0.312544549897452 3320 46494817
SGTC_360 0957-0399 1.01 µM -0.48943993187279 0.311513221764842 no 2313 0.312265135631971 3371 6752301 YPR165W RHO1
SGTC_3135 9127742 49.47 µM -0.489637400503909 0.311444155649472 no 2314 0.312195252999584 3277 3643468
SGTC_2085 5307070 144.047 µM -0.489803867061689 0.311385937892945 no 2315 0.312136347011461 3216 2840351
SGTC_2679 rapamycin 1 nM -0.492263911507215 0.310526145807069 no 2316 0.311266394321102 3340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2497 7-hydroxyflavone 100 µM -0.492325949003967 0.31050447688541 no 2317 0.311244469413893 3371 5281894
SGTC_1882 5615643 20 µM -0.493048403506665 0.3102521809963 no 2318 0.310989193348368 3320 2253075
SGTC_875 0709-0210 25.7 µM -0.493167457705479 0.310210613400182 no 2319 0.310947134802689 3379 6251364
SGTC_3223 9129970 49.47 µM -0.493283024154398 0.310170265865957 no 2320 0.310906310744175 3254 17248386
SGTC_2143 5623677 140.463 µM -0.49463507163741 0.309698397495615 no 2321 0.310428870497007 3335 5375313
SGTC_1149 3909-7961 23.3 µM -0.496823462390284 0.308935307428844 no 2322 0.309656774184124 3311 735261
SGTC_2251 lansoprazole 556 µM -0.499600356550745 0.307968192890803 no 2323 0.308678253382247 3196 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_43 0570-0105 72.5 µM -0.501752267997088 0.307219658023762 no 2324 0.307920896406739 3325 1114046 YDL195W SEC31
SGTC_3201 9113999 49.47 µM -0.502724043808789 0.306881892034124 no 2325 0.307579151358454 3388 16649224
SGTC_1485 3909-9022 254 µM -0.502844204162243 0.306840138552563 no 2326 0.307536906077329 3366 714516
SGTC_2654 protoveratrine a 100 µM -0.503548985892326 0.306595290511091 no 2327 0.307289174404288 3305 5702278 A heart drug and vasodilator.
SGTC_165 k038-0023 64.381 µM -0.503732985985785 0.306531381286794 no 2328 0.307224512604283 3291 46368543
SGTC_950 1165-0508 94.1 µM -0.505100077837261 0.306056730111433 no 2329 0.306744273354688 3337 6148369
SGTC_376 3970-0862 59.1 µM -0.505656231264752 0.30586372799045 no 2330 0.306548999662819 3378 3135186
SGTC_1685 st024049 53.0905 µM -0.505848659778463 0.305796962003531 no 2331 0.30648144794969 3346 1941139
SGTC_2584 androsterone 48.74 µM -0.506599762443439 0.305536417339442 no 2332 0.306217837532668 3385 2754130 A steroid.
SGTC_1124 fisetin 1.16336 µM -0.506959976013491 0.305411500333855 no 2333 0.30609145090902 3309 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_63 0099-0242 26.702 µM -0.509541442369296 0.304516947652675 no 2334 0.305186378689958 3404 3898502 YLR359W ADE13
SGTC_366 0181-0206 4.31 µM -0.512217695761364 0.303590781413811 no 2335 0.304249329866914 3479 274874
SGTC_865 0488-0499 301 µM -0.512385974266653 0.303532587620778 no 2336 0.304190452588118 3434 9634651
SGTC_3057 9095946 49.47 µM -0.514496826940844 0.302803039662303 no 2337 0.303452339130063 3361 24540043
SGTC_1831 st055328 12 µM -0.516543494095297 0.302096426106563 no 2338 0.302737434755771 3409 1103068
SGTC_2190 6049624 200 µM -0.518611528685161 0.301383188389833 no 2339 0.302015833969829 3342 2265554
SGTC_1140 3229-1848 2.98 µM -0.518824327814476 0.301309839825172 no 2340 0.30194162567109 3396 2849525
SGTC_658 3253-0951 102 µM -0.519385507087867 0.301116448580855 no 2341 0.301745967929893 3358 1184878
SGTC_164 4100-3994 89.624 µM -0.521736516174478 0.300306862426977 no 2342 0.300926898111127 3461 4615967
SGTC_472 calcifediol 10 µM -0.523414054196487 0.299729792785574 no 2343 0.300343073011121 3383 5283731 A vitamin D metabolite.
SGTC_1351 1496-0003 46.5 µM -0.523558490421485 0.29968013051149 no 2344 0.300292829541125 3424 3891978
SGTC_1215 3852-0577 11.2 µM -0.523790122884747 0.29960049487511 no 2345 0.300212261989686 3448 2884876
SGTC_1899 st063254 59.6 µM -0.527492996811958 0.29832874464281 no 2346 0.298925639211701 3305 3093813
SGTC_2131 toluylene red 5.2905 µM -0.527648754633001 0.298275303594843 no 2347 0.298871573600926 3327 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_878 0828-0289 13.7 µM -0.527733149258786 0.298246349327217 no 2348 0.298842280960038 3373 745350 YLR208W SEC13
SGTC_2301 7769476 200 µM -0.529395967853291 0.297676127617169 no 2349 0.29826539735173 3357 977820
SGTC_1416 3966-0321 25.3 µM -0.530341519941595 0.297352096402473 no 2350 0.297937582171569 3377 582530 YLR208W SEC13
SGTC_1596 piperlongumine 63 µM -0.531392635037898 0.296992079049395 no 2351 0.297573362061503 3459 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2884 9058502 51.95 µM -0.532589174047278 0.296582495414273 no 2352 0.297158998907672 3426 6471554
SGTC_885 0865-0106 16.8 µM -0.537021749784332 0.295067453620348 no 2353 0.295626295227966 3387 2793380
SGTC_453 enantio-paf c16 10 µM -0.537773019183445 0.294811025565909 no 2354 0.29536688056841 3422 13871343 A lipid and platelet activating factor
SGTC_2838 9002687 71.43 µM -0.538033692641206 0.294722074855394 no 2355 0.295276894041425 3311 6457060
SGTC_277 nystatin 15.5 µM -0.53959499962939 0.294189562696678 no 2356 0.294738182902266 3294 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_554 4483-2211 187 µM -0.539851019745678 0.294102284818554 no 2357 0.294649889355497 3396 747107
SGTC_1029 k015-0030 64.7 µM -0.540393079749281 0.293917534751343 no 2358 0.294462989629788 3415 2208316
SGTC_145 3737-0113 38.366 µM -0.54169764388289 0.293473120914778 no 2359 0.294013406560046 3466 6849351
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.542492532163934 0.293202486345055 no 2360 0.293739625295289 3346 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2528 xanthyletin 44.79 µM -0.542515296759057 0.293194737417862 no 2361 0.293731786284107 3358 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2906 7926292 26.41 µM -0.542774304855873 0.293106579352515 no 2362 0.293642603403658 3448 2966319
SGTC_1210 3013-0140 750 nM -0.542890757617355 0.293066946566858 no 2363 0.293602509928859 3445 905973
SGTC_674 0498-0004 451 µM -0.543182796863517 0.292967566738702 no 2364 0.293501975002662 3376 4231473
SGTC_1400 3771-8998 51.5 µM -0.544889326325695 0.292387154261618 no 2365 0.292914818853833 3370 670767
SGTC_1609 st001574 46.4 µM -0.545216380611393 0.292275979999801 no 2366 0.292802353374346 3342 3960012
SGTC_1896 st058441 89 µM -0.547029313654169 0.29166007376095 no 2367 0.292179296648754 3357 688759
SGTC_2430 5571206 200 µM -0.55017748324882 0.29059198859697 no 2368 0.291098822969797 3494 1731771
SGTC_3082 9117008 49.47 µM -0.550715892830997 0.290409504820396 no 2369 0.290914224089615 3388 41448529
SGTC_705 1124-0212 310 µM -0.551263881134066 0.290223829625095 no 2370 0.290726397250047 3468 9554485
SGTC_1859 st055998 20 µM -0.551322036128542 0.290204128199063 no 2371 0.290706467546321 3495 676301
SGTC_2447 5741742 33.78 µM -0.552781268947815 0.289709982645524 no 2372 0.29020659807753 3428 1776504
SGTC_2514 salinomycin 42.74 µM -0.557036343666301 0.288271329633731 no 2373 0.2887512990815 3479 23682228 A polyether potassium ionophore.
SGTC_3229 9132204 49.47 µM -0.558702362863946 0.287708963051621 no 2374 0.288182433240883 3420 17682924
SGTC_1307 1187-1599 12.2 µM -0.559207103606545 0.287538689642525 no 2375 0.288010192840253 3346 1538471
SGTC_2953 9074162 66.49 µM -0.560683447058392 0.287040921433264 no 2376 0.287506676725147 3434 16451992
SGTC_201 4262-0159 12.803 µM -0.560776071737838 0.287009705439523 no 2377 0.287475100383509 3410 1341029
SGTC_1086 cerivastatin 2.18 µM -0.562038080216203 0.286584548745769 no 2378 0.287045037159633 3439 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_563 tetrahydrosecaminediol 614 µM -0.564544322405847 0.2857411103103 no 2379 0.286191872492061 3495 334274 A psychoactive constituent of the cannabis plant.
SGTC_963 1269-2853 151 µM -0.565408789256737 0.285450461007112 no 2380 0.285897873849311 3395 3668223
SGTC_1365 1672-3266 55.4 µM -0.566030431682271 0.285241540690576 no 2381 0.285686546750196 3481 6415873
SGTC_794 k038-0031 316 µM -0.566491021374356 0.285086793651552 no 2382 0.285530017410985 3511 6624242
SGTC_314 1671-0008 2.74 µM -0.567445017022807 0.284766401456282 no 2383 0.285205936184392 3402 3913060
SGTC_1015 4130-4525 82 µM -0.567823232622008 0.2846394282034 no 2384 0.285077501354643 3362 1363237
SGTC_1381 2324-0066 62.1 µM -0.569969688760121 0.283919339732518 no 2385 0.284349128413529 3452 10885928
SGTC_12 0849-0099 9.267 µM -0.571567772010101 0.28338378502834 no 2386 0.283807417145011 3436 6071388
SGTC_3183 9108214 49.47 µM -0.572783909686059 0.282976553933805 no 2387 0.283395507463618 3420 4974831
SGTC_2950 9072895 21.46 µM -0.575409160267515 0.28209843188356 no 2388 0.282507305202476 3456 17332245
SGTC_776 4476-4378 112 µM -0.575438907814807 0.282088489126299 no 2389 0.282497248375128 3479 2892008
SGTC_536 3852-0578 10.6 µM -0.576240769553745 0.281820540151197 no 2390 0.282226225863371 3522 2869208
SGTC_2743 auranofin 4.32 µM -0.57851140840769 0.281062452845043 no 2391 0.281459448680939 3415 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.579156006102448 0.280847423782482 no 2392 0.281241956343859 3484 616764
SGTC_1767 st044992 70.3 µM -0.57924900921274 0.280816405770929 no 2393 0.281210583062118 3435 9600693
SGTC_2200 6600604 21.907 µM -0.579683870506116 0.280671394619553 no 2394 0.281063911194516 3443 2904777
SGTC_723 4182-0001 115 µM -0.580184403490137 0.280504529093687 no 2395 0.280895135065402 3416 744821 YLR208W SEC13
SGTC_1162 k048-0130 20.1 µM -0.580334914833191 0.280454361663484 no 2396 0.280844393303351 3437 6797406
SGTC_3165 9101544 49.47 µM -0.581429085439948 0.280089790679148 no 2397 0.280475649758061 3491 5002184
SGTC_205 1486-1330 71.903 µM -0.582452637109056 0.279748957559164 no 2398 0.280130917607088 3479 4118834
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.582695978993962 0.279667956608659 no 2399 0.280048990292946 3488 229346 A bile salt which induces apoptosis.
SGTC_2 0422-0095 29 µM -0.584219703943646 0.279161014877775 no 2400 0.279536253254898 3411 6790840
SGTC_217 ketoconazole 989 nM -0.584332781556035 0.279123411884572 no 2401 0.27949822054711 3452 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_180 1486-1293 102.781 µM -0.585870962147451 0.278612147811244 no 2402 0.278981116107707 3561 4140536
SGTC_586 0957-0265 8.15 µM -0.587624782500863 0.278029765890674 no 2403 0.278392086413781 3442 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_92 0063-0024 660.874 µM -0.588084708491204 0.277877139042668 no 2404 0.278237718246465 3520 3594437
SGTC_119 0121-0043 24.815 µM -0.588152945545001 0.27785449800049 no 2405 0.278214818924137 3570 1092378
SGTC_525 k781-2675 26.7 µM -0.589690860697078 0.277344457042131 no 2406 0.277698961777639 3542 3651118 YDL195W SEC31
SGTC_189 3970-0742 2.116 µM -0.590951929260807 0.276926572602302 no 2407 0.277276315140839 3533 2891807
SGTC_1285 0929-0069 65.5 µM -0.591237563972163 0.276831963729002 no 2408 0.277180628496964 3464 1206237
SGTC_2372 9071633 200 µM -0.591649462351868 0.276695561266803 no 2409 0.277042672411216 3533 21321366
SGTC_1372 2752-0194 270 µM -0.594315338850053 0.275813538462291 no 2410 0.276150610635034 3494 823334
SGTC_2692 st077426 47.7 µM -0.594656444173916 0.27570078129494 no 2411 0.27603657100461 3518 25238571
SGTC_2044 5102272 200 µM -0.594927698692551 0.275611130471887 no 2412 0.275945900670734 3508 592666
SGTC_895 0964-0006 13.7 µM -0.596021968152395 0.27524961517106 no 2413 0.275580275547288 3515 6738897
SGTC_2385 9074692 200 µM -0.596097349910354 0.27522471979304 no 2414 0.27555509722955 3466 17046906
SGTC_2375 9072683 200 µM -0.596179701811225 0.275197523741302 no 2415 0.275527592102244 3568 16798029
SGTC_121 0557-0495 61.343 µM -0.596512767306559 0.275087545043675 no 2416 0.275416363651466 3552 3104427
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.597679209031872 0.274702555074502 no 2417 0.27502700038527 3478 688761
SGTC_1833 st055984 71 µM -0.597933235346896 0.274618747654318 no 2418 0.274942241278964 3461 676288
SGTC_1418 3966-3099 2.4 µM -0.598236187581098 0.274518815267976 no 2419 0.274841174249631 3522 740335
SGTC_3038 9091290 49.47 µM -0.600831105537958 0.273663586577614 no 2420 0.273976242008731 3559 25236843
SGTC_2823 7987624 58.44 µM -0.600976685247335 0.273615645739977 no 2421 0.273927757589767 3590 2239440
SGTC_1254 0550-0035 264 µM -0.601809362018025 0.273341516933062 no 2422 0.27365052129274 3534 15121435
SGTC_2595 hexamethylquercetagetin 100 µM -0.60294807267577 0.272966857819543 no 2423 0.273271617142196 3445 386331
SGTC_3298 9116858 71.43 µM -0.603495836511504 0.272786723049819 no 2424 0.273089442220639 3539 2506942
SGTC_1930 st074634 34.3 µM -0.604053729452597 0.272603317914304 no 2425 0.272903960461004 3507 684253 YOR116C RPO31
SGTC_2439 5492030 7.2 µM -0.605820327838347 0.272022959653708 no 2426 0.272317034817012 3482 5722370
SGTC_1290 0986-0249 10.2 µM -0.607011954765579 0.271631836810885 no 2427 0.271921489255916 3494 53329
SGTC_1011 4112-3381 17.4 µM -0.607214208993904 0.271565479536685 no 2428 0.271854381892173 3582 2877139
SGTC_724 3910-0327 137 µM -0.607730817423216 0.271396022935481 no 2429 0.271683010132471 3520 2885483
SGTC_1332 1480-0653 17.5 µM -0.607926357938593 0.271331895974018 no 2430 0.271618158552915 3510 5749438
SGTC_2409 alverine citrate 63.97 µM -0.608267250645056 0.271220119230789 no 2431 0.271505118931865 3609 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_566 0958-0068 16.5 µM -0.609328872675831 0.270872166647566 no 2432 0.27115323649539 3543 6815365
SGTC_896 0964-0007 44.5 µM -0.609782755484222 0.270723472021665 no 2433 0.271002863123146 3521 6756758
SGTC_1553 gossypol 38.6 µM -0.610336156108099 0.270542229941324 no 2434 0.270819575361891 3475 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_289 k017-0060 526 µM -0.610455386288297 0.270503189268276 no 2435 0.270780094111727 3485 5512909
SGTC_3055 9094636 49.47 µM -0.610755344097643 0.270404983677226 no 2436 0.2706807803809 3590 25236176
SGTC_2377 9073351 62.6 µM -0.611047351296217 0.270309398220319 no 2437 0.270584116512058 3465 7337946 YHR072W ERG7
SGTC_2053 5265679 138 µM -0.611347359956753 0.270211211165657 no 2438 0.270484821860974 3499 764595
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.611641808227429 0.270114861265623 no 2439 0.270387385253416 3506 23665772 A membrane-active detergent.
SGTC_798 1287-0182 476 µM -0.614254012061595 0.269260844418511 no 2440 0.269523743328664 3577 1649755
SGTC_2484 5809818 12.04 µM -0.614711331652362 0.269111470759645 no 2441 0.269372687506124 3519 2870548
SGTC_2790 5423970 71.43 µM -0.614782730931067 0.269088153466243 no 2442 0.269349107662166 3567 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1327 1436-0082 2.18 µM -0.614839642094491 0.269069568370253 no 2443 0.269330313306677 3491 15992205
SGTC_2188 6126565 140.678 µM -0.615909404777654 0.268720343066353 no 2444 0.268977157037966 3508 874518
SGTC_640 3381-0960 37.1 µM -0.617011845855803 0.268360688269502 no 2445 0.268613456167209 3577 1745025
SGTC_727 3032-0951 202 µM -0.618102409182621 0.268005146765001 no 2446 0.268253917155237 3493 3652836
SGTC_475 α-linolenic acid 10 µM -0.618264655377861 0.267952272121857 no 2447 0.268200448214858 3641 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1824 st053723 68.6 µM -0.619025035363497 0.267704540826542 no 2448 0.267949933159737 3526 675225
SGTC_1880 MG-132 525 µM -0.619224028456594 0.267639728069625 no 2449 0.267884392285062 3514 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2617 dihydrotanshinone i 20.83 µM -0.62021563052644 0.267316877704756 no 2450 0.267557916103397 3552 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2808 7946468 45.46 µM -0.620274908220618 0.267297584026433 no 2451 0.267538405804929 3523 2970879
SGTC_2244 6635614 200 µM -0.621578108189502 0.266873596664597 no 2452 0.267109659837754 3419 836499
SGTC_989 1501-0895 10.3 µM -0.621658480580874 0.266847459174642 no 2453 0.267083229102663 3549 2830112
SGTC_3129 9127257 49.47 µM -0.622318933157717 0.266632725801496 no 2454 0.266866087040774 3434 837894
SGTC_1888 azatryptophan 97.5 µM -0.622516322839627 0.266568565328098 no 2455 0.266801207036891 3522 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2289 7946404 165.07 µM -0.622546578048454 0.266558731722395 no 2456 0.266791263158491 3573 1246120 YPR165W RHO1
SGTC_3059 1327-0034 3 µM -0.62278603720977 0.266480908721148 no 2457 0.266712567523822 3504 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_431 k089-0097 107 µM -0.624026548545241 0.26607793296118 no 2458 0.266305074967627 3530 5499420
SGTC_446 go6976 132 µM -0.624051805911963 0.266069731401026 no 2459 0.266296781510682 3531 3501 A protein kinase C inhibitor.
SGTC_2708 st078559 56 µM -0.625063277481491 0.265741392096715 no 2460 0.265964764259711 3505 17250902
SGTC_1388 3346-4487 254 µM -0.625214401644554 0.265692352501443 no 2461 0.265915175511732 3571 3345614
SGTC_2596 sinensetin 100 µM -0.625744715100567 0.265520302781243 no 2462 0.26574119950822 3492 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3168 9103419 49.47 µM -0.632051708926321 0.263478465769091 no 2463 0.263676544527092 3529 16649256
SGTC_3099 9120367 49.47 µM -0.632380573173231 0.263372218949862 no 2464 0.263569112549379 3600 24824940
SGTC_1610 st001799 48.1 µM -0.632719804953645 0.26326264559581 no 2465 0.263458317157394 3493 621897
SGTC_1982 st072467 71.9 µM -0.633051723518281 0.263155456982543 no 2466 0.263349933326071 3512 3163533
SGTC_3243 9134147 49.47 µM -0.634002821423989 0.262848436303651 no 2467 0.263039490406902 3606 24282180
SGTC_652 0437-0092 114 µM -0.634382356998953 0.262725970867408 no 2468 0.262915660404427 3561 3091274
SGTC_2515 chrysin 20.77 µM -0.634665700482243 0.26263456294202 no 2469 0.262823234159269 3542 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1879 gemcitabine 100 µM -0.63575709419687 0.262282626379289 no 2470 0.262467378401739 3558 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1657 st012939 43.4 µM -0.636612987027033 0.262006799773324 no 2471 0.262188481854237 3591 24207257
SGTC_2824 7998404 51.95 µM -0.63700653846908 0.261880020785316 no 2472 0.262060292318739 3546 837851
SGTC_1526 st051518 75 µM -0.637855681601367 0.261606584322827 no 2473 0.261783814664747 3485 673993
SGTC_3352 9151559 45.5865 µM -0.639072054725123 0.261215149906941 no 2474 0.261388029229014 3524 17159339
SGTC_1102 cgs 12066b 26.1 µM -0.639917282791061 0.26094332899316 no 2475 0.261113188647779 3534 6438352 A 5-HT1B full agonist.
SGTC_3293 9120939 62.045 µM -0.639978194608272 0.260923745692757 no 2476 0.261093387852324 3585 934087
SGTC_515 4092-1064 102 µM -0.640042849269869 0.260902959885562 no 2477 0.261072371203173 3619 717353
SGTC_298 1391-0729 10 µM -0.640194126600145 0.260854329111036 no 2478 0.261023200380939 3558 3237558
SGTC_1399 3562-5772 25 µM -0.64038460761977 0.260793102249364 no 2479 0.260961293657956 3538 23847490
SGTC_662 k832-1615 104 µM -0.64097119976232 0.260604598704994 no 2480 0.260770697443132 3565 5878478
SGTC_1572 epiandrosterone 68.9 µM -0.642548751552766 0.260097994811258 no 2481 0.260258472998597 3557 441302 A steroid.
SGTC_1709 st033179 39.1045 µM -0.644100836905401 0.259600064973469 no 2482 0.25975502385212 3569 573381
SGTC_2141 5621638 7.665 µM -0.644439224365447 0.259491571111236 no 2483 0.259645328050151 3598 2856238
SGTC_572 0960-0087 17.7 µM -0.644667513855094 0.259418390114955 no 2484 0.259571336458699 3545 6796365
SGTC_541 4513-1321 94 µM -0.644690590814898 0.259410993105762 no 2485 0.259563857521956 3519 747515
SGTC_1798 st045719 60.953 µM -0.644854199847588 0.259358553554705 no 2486 0.25951083719434 3542 3980186
SGTC_1688 st021091 57.6 µM -0.645155092157482 0.25926212661696 no 2487 0.259413342457618 3600 3656366
SGTC_308 4092-1169 104 µM -0.646387983422051 0.258867215614684 no 2488 0.259014060310772 3562 2268590 YDL196W YDL196W
SGTC_1499 4480-0877 67.3 µM -0.647369226193323 0.258553133446832 no 2489 0.25869650392962 3530 2861909
SGTC_936 3005-4620 401 µM -0.648502835721957 0.258190526643267 no 2490 0.258329888662539 3625 777207
SGTC_744 1594-0068 283 µM -0.649670627467871 0.257817261864571 no 2491 0.257952500416036 3612 668392
SGTC_3268 9137683 49.47 µM -0.651668111750491 0.257179449772504 no 2492 0.25730764903984 3609 1953228
SGTC_944 3370-0224 231 µM -0.651893478665436 0.257107539920116 no 2493 0.257234946074664 3591 4580514
SGTC_1486 3970-0793 4.53 µM -0.65275985501285 0.256831194805939 no 2494 0.256955554077309 3623 2844330
SGTC_2602 kawain 100 µM -0.653046775974897 0.256739710689956 no 2495 0.256863061640273 3600 5369129
SGTC_884 0851-0618 334 µM -0.653408208856212 0.256624492762415 no 2496 0.256746574050423 3603 9642473
SGTC_3239 9133757 49.47 µM -0.653487969996496 0.256599070055363 no 2497 0.256720871231135 3593 17036923
SGTC_221 trifluoperazine 10.304 µM -0.654076159688511 0.256411633627929 no 2498 0.256531370010522 3619 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2055 5235184 200 µM -0.654765157655607 0.256192163735103 no 2499 0.256309483380306 3610 2836034
SGTC_1732 st034308 51.822 µM -0.655644863280201 0.255912089231308 no 2500 0.256026326248527 3534 830119
SGTC_1754 st042065 16.137 µM -0.657912826748009 0.255190768555613 no 2501 0.255297074011478 3574 1126236 YIL048W NEO1
SGTC_77 0828-0286 12.516 µM -0.658399074585482 0.25503625704528 no 2502 0.255140864944793 3586 745345
SGTC_1225 1216-0074 20.6 µM -0.65845532047693 0.255018387347722 no 2503 0.255122798952774 3592 4241466
SGTC_2313 7726885 200 µM -0.66087989447941 0.254248707058814 no 2504 0.254344670380026 3590 726423
SGTC_393 acivicin 6.25 µM -0.661702281231342 0.253987917533265 no 2505 0.254081021218679 3534 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1937 st074714 47.2 µM -0.662079707058339 0.25386827790576 no 2506 0.253960070197017 3577 17250970
SGTC_1743 st037606 46.3785 µM -0.662866939534494 0.253618829530607 no 2507 0.253707888562334 3630 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2138 5575593 77.673 µM -0.663485247798643 0.253422998052561 no 2508 0.25350991226073 3615 762213
SGTC_1983 st071813 46.9 µM -0.664106202563617 0.253226408380288 no 2509 0.253311170298228 3604 11838595
SGTC_1588 farnesol 29.9 µM -0.664708666025042 0.253035749590951 no 2510 0.253118424954025 3637 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2571 chrysanthemic acid 100 µM -0.665343671418294 0.252834874194017 no 2511 0.252915352050132 3568 2743 An insecticide.
SGTC_813 k007-0158 173 µM -0.665416632992127 0.25281179916166 no 2512 0.252892024641394 3627 6523916
SGTC_2300 7976697 71.57 µM -0.667364958367096 0.252196026628329 no 2513 0.252269521588166 3553 2236109
SGTC_2949 9072542 2.23 µM -0.667864732068392 0.252038199615195 no 2514 0.252109970835713 3639 16457352
SGTC_1567 st069303 68.4 µM -0.668214921777742 0.251927641829382 no 2515 0.251998205898249 3653 5581319
SGTC_2206 7254556 146.969 µM -0.668242084714788 0.251919067335428 no 2516 0.251989537792912 3617 4398905
SGTC_1314 1222-0010 41.1 µM -0.669505780128393 0.251520328347717 no 2517 0.251586447400047 3624 3526027
SGTC_1115 galangin 695.678 nM -0.669786205049016 0.251431889957196 no 2518 0.251497044366512 3662 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1606 st000094 49.2 µM -0.671613446354423 0.250856030434052 no 2519 0.250914907906737 3666 1242210
SGTC_2581 avocatin a 64 µM -0.671932875620036 0.250755433270054 no 2520 0.250813214981768 3637 6710728 A skin care supplement.
SGTC_948 3448-0295 75.3 µM -0.673010641178559 0.250416172593554 no 2521 0.250470260560066 3655 678569
SGTC_1373 2887-0003 58.5 µM -0.673882762853017 0.250141822993589 no 2522 0.25019292583557 3622 776948
SGTC_577 r071-0003 38.6 µM -0.674691997706641 0.249887398824627 no 2523 0.249935734863126 3672 4568517 YMR134W ERG29
SGTC_2202 7226349 200 µM -0.675267545907259 0.249706529573284 no 2524 0.249752899591558 3592 844334
SGTC_3167 9103034 49.47 µM -0.675387961315614 0.249668697151957 no 2525 0.249714656031557 3640 5127859
SGTC_2414 st077232 92.9 µM -0.675660688308938 0.249583022343922 no 2526 0.249628050284312 3602 729801
SGTC_1321 1326-2144 215 µM -0.675973982151841 0.249484623093036 no 2527 0.249528582036613 3618 3513030
SGTC_1407 3909-7909 12.3 µM -0.676761149731841 0.249237480695997 no 2528 0.249278755687839 3649 4411780
SGTC_3244 9134489 49.47 µM -0.677415922044613 0.249032004891912 no 2529 0.249071049489015 3608 16584271
SGTC_2752 diclazuril 33.15 µM -0.67811753385042 0.248811930336626 no 2530 0.248848587143233 3687 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.679336041835078 0.24842996716912 no 2531 0.24846248234406 3652 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2732 terfenadine 20 µM -0.679843342257878 0.248271036944255 no 2532 0.248301829825257 3635 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3310 9130229 44.1445 µM -0.680710772975953 0.24799940851181 no 2533 0.248027259160911 3658 7761258
SGTC_1490 4089-0339 670 nM -0.681320115379061 0.247808693067621 no 2534 0.247834478939883 3613 742542
SGTC_1763 st044482 94.5 µM -0.682241780235705 0.247520374016824 no 2535 0.247543040010578 3650 88505
SGTC_796 1234-0020 70.7 µM -0.68228176299648 0.247507870500056 no 2536 0.247530401237912 3614 46495034
SGTC_2344 7990960 76.95 µM -0.682541863384033 0.247426539444734 no 2537 0.247448190478518 3633 140813
SGTC_173 1273-0061 2.693 µM -0.683816141658142 0.2470282905527 no 2538 0.247045636219104 3610 2847414 YPL266W DIM1
SGTC_1818 st052136 56.3 µM -0.685535368078978 0.24649152641838 no 2539 0.246503075138512 3559 674169
SGTC_1080 nisoldipine 24.4 µM -0.68726125038274 0.245953313426044 no 2540 0.245959056362577 3645 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1512 0259-0544 12.2 µM -0.687339395609799 0.245928958922649 no 2541 0.24593443930548 3649 18476
SGTC_3221 9128209 49.47 µM -0.687525776660247 0.245870877196823 no 2542 0.245875731486392 3689 16460723
SGTC_1649 st011737 51.3 µM -0.687742039295098 0.245803492733604 no 2543 0.245807620751075 3642 1761035
SGTC_3139 9095020 49.47 µM -0.687986274935897 0.245727404188101 no 2544 0.245730712250087 3470 25236292
SGTC_1113 artemisinin 1.17947 µM -0.688347375075798 0.245614931150889 no 2545 0.245617027417863 3676 2240 An anti-malaria and mitochondrial poison.
SGTC_1575 cyproterone acetate 48 µM -0.689064914368715 0.245391518933267 no 2546 0.245391209028709 3618 9880 An androgen receptor antagonist and liver toxin.
SGTC_2745 rifampicin 24.3 µM -0.689168544805317 0.245359261706356 no 2547 0.245358604486529 3583 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3220 9131269 49.47 µM -0.689304286576741 0.245317012576122 no 2548 0.245315900495211 3697 17722206
SGTC_2450 5739737 12.93 µM -0.689559948271919 0.245237449427676 no 2549 0.245235480872465 3659 2262825
SGTC_2088 5278280 127.392 µM -0.690532539580825 0.244934901158339 no 2550 0.244929677140072 3703 791502
SGTC_2876 9059903 25.97 µM -0.693087773631429 0.244140991131433 no 2551 0.244127234976628 3636 6916095
SGTC_1279 0874-0590 65.2 µM -0.694903088495139 0.243577817855328 no 2552 0.243558018520524 3691 3523074
SGTC_3248 9135562 49.47 µM -0.694978117646394 0.243554556333073 no 2553 0.243534507554134 3693 17650701
SGTC_1719 st032227 49.2 µM -0.695337322046091 0.243443207694639 no 2554 0.243421965054904 3682 3125804
SGTC_2878 9043973 25.97 µM -0.695807561986606 0.243297481078822 no 2555 0.243274676440209 3704 6465167
SGTC_649 1123-0311 367 µM -0.69634073896579 0.243132307425978 no 2556 0.2431077329686 3644 693629 YIL048W NEO1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.69652533027357 0.243075136756014 no 2557 0.243049949876169 3658 803109
SGTC_3252 9135871 49.47 µM -0.697802937660144 0.24267964214028 no 2558 0.242650220844999 3690 17682838
SGTC_373 0844-0104 25.9 µM -0.698265301494226 0.242536599242631 no 2559 0.242505647385734 3701 5375804
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.69876580365152 0.242381808859875 no 2560 0.242349201310739 3679 688669
SGTC_3328 9140624 29.0385 µM -0.699757997609411 0.242075111169973 no 2561 0.242039224821563 3682 4904392
SGTC_2318 6029776 164 µM -0.700395078619851 0.241878293660704 no 2562 0.241840304430257 3676 818325
SGTC_3355 9151058 44.0485 µM -0.700630051806355 0.241805723814018 no 2563 0.241766959458838 3690 17015728
SGTC_1779 st039427 55 µM -0.700790469920673 0.241756186574172 no 2564 0.241716893182591 3713 1124498
SGTC_2683 piperine 63.03 µM -0.701649521249497 0.241491004593476 no 2565 0.241448880210029 3657 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_235 0330-0087 5 mM -0.702362685998335 0.241270976654148 no 2566 0.241226504657803 3701 46494818 YHR062C RPP1
SGTC_1612 st002233 45.4 µM -0.70374713882199 0.240844151909484 no 2567 0.240795129309491 3696 1035021
SGTC_160 3453-0671 289.699 µM -0.703892076509646 0.240799491603023 no 2568 0.24074999311984 3682 5322268
SGTC_2185 6113692 200 µM -0.704431662178483 0.240633266247622 no 2569 0.240581996970813 3665 874150
SGTC_2069 5228469 200 µM -0.705774230112974 0.240219944487906 no 2570 0.240164275123166 3654 2835210
SGTC_1046 2001-0062 216 µM -0.705800846125966 0.240211754418877 no 2571 0.240155997908911 3627 739778
SGTC_3292 9120825 59.784 µM -0.706668734118484 0.2399447781887 no 2572 0.239886181886805 3699 24824900
SGTC_656 4090-1979 187 µM -0.707589992029529 0.239661561662472 no 2573 0.239599954798212 3691 22330961
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.707799788059544 0.239597090902616 no 2574 0.239534799005685 3696 442882
SGTC_2198 6589944 200 µM -0.707913235081826 0.239562232338966 no 2575 0.239499570097177 3660 5290268
SGTC_3010 9080089 71.4286 µM -0.707991687896355 0.239538127971501 no 2576 0.239475209657835 3681 17027233
SGTC_2659 sanguinarine 24.21 µM -0.708594593060539 0.239352931551521 no 2577 0.239288046304299 3643 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_83 0170-0301 39.027 µM -0.71243292921739 0.238175732755029 no 2578 0.238098365260641 3647 3089716
SGTC_2685 mycophenolic acid 18.85 µM -0.712786766071278 0.238067372663091 no 2579 0.237988857983066 3676 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2796 7949634 45.45 µM -0.713440415011825 0.237867268271156 no 2580 0.237786635927073 3685 2971588
SGTC_2148 5546263 113.568 µM -0.714240953004075 0.237622321798331 no 2581 0.237539098650128 3702 792097
SGTC_1230 0170-0365 3.77 µM -0.716229696851232 0.237014410728539 no 2582 0.236924764445601 3792 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1435 4092-0789 56.7 µM -0.718977934501144 0.236175749279562 no 2583 0.236077257676245 3703 2248285
SGTC_1297 1068-0111 14.1 µM -0.719306645062165 0.23607554841802 no 2584 0.235976001241403 3663 767057
SGTC_3274 9138298 49.47 µM -0.719763992461943 0.23593617415305 no 2585 0.235835159169982 3677 17015756
SGTC_921 1561-0023 372 µM -0.721505118881571 0.235405990036512 no 2586 0.235299396182886 3700 24050882
SGTC_3273 9137859 49.47 µM -0.723008856154995 0.23494862212117 no 2587 0.23483722162634 3775 2377234
SGTC_1043 0916-0009 19.3 µM -0.723283607473954 0.234865108456246 no 2588 0.234752830891158 3729 3101130
SGTC_1436 4092-1007 8.32 µM -0.724160537620291 0.234598665741686 no 2589 0.23448359121539 3702 2881121
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.72421420372539 0.234582365491445 no 2590 0.2344671199165 3691 15053
SGTC_2426 5582046 32.21 µM -0.724319101710483 0.234550506158165 no 2591 0.234434926284089 3701 2251934
SGTC_1239 0337-0584 35.4 µM -0.724827163402458 0.234396232904213 no 2592 0.234279034631607 3759 914301 YML130C ERO1
SGTC_745 0469-0705 296 µM -0.728382604936419 0.233318193725288 no 2593 0.23318970428592 3792 3486736
SGTC_348 k064-0012 10.7 µM -0.729130384199996 0.233091811576048 no 2594 0.232960955070582 3664 5066323
SGTC_1872 amphotericin b 148 nM -0.730227491653543 0.232759894902001 no 2595 0.232625570389495 3735 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2023 5144124 124 µM -0.730896424509258 0.232557646269876 no 2596 0.232421210059191 3734 2830192
SGTC_2973 9094665 17.96 µM -0.73186421968504 0.232265211071623 no 2597 0.232125723506013 3750 25237061 YIL048W NEO1
SGTC_2184 6075246 200 µM -0.73356582725281 0.231751538905733 no 2598 0.231606697251077 3780 2267320
SGTC_1527 coumarin 137 µM -0.733872676631259 0.231658976266854 no 2599 0.231513170594018 3780 323 A hepatotoxic, DNA x-linker.
SGTC_3060 1327-0027 12.5 µM -0.734554621094808 0.231453338124332 no 2600 0.23130539163044 3674 16000455 YPR107C YTH1
SGTC_10 0279-0212 42.575 µM -0.739592997687898 0.229937189930454 no 2601 0.229773495898183 3746 39851 YBR002C RER2
SGTC_1206 3978-0017 132 µM -0.739890521096395 0.229847833355039 no 2602 0.229683213236347 3790 3873677
SGTC_919 tnp00227 403.569 nM -0.741072034030835 0.229493176098652 no 2603 0.229324882564898 3747 1269246 A methoxyflavone. YNL221C POP1
SGTC_1791 st048313 56.1 µM -0.74253527928284 0.229054376018623 no 2604 0.228881542499519 3680 1204976
SGTC_2622 2-methoxyxanthone 59.94 µM -0.74299524191101 0.228916539060076 no 2605 0.22874228056376 3765 71034 A hepatoprotective.
SGTC_3281 9140613 49.47 µM -0.74410111356225 0.228585333169322 no 2606 0.22840765284542 3698 16013766
SGTC_1479 0549-0158 134 µM -0.744755107220056 0.228389590365062 no 2607 0.228209889219917 3791 5440202
SGTC_1383 3049-0032 20.7 µM -0.745965301393519 0.228027623151961 no 2608 0.227844188014169 3777 712864
SGTC_973 1325-0077 65.9 µM -0.748909995525096 0.227148218794571 no 2609 0.22695572766613 3784 2835149
SGTC_1834 st055981 52.8 µM -0.749059477717994 0.227103628431499 no 2610 0.22691067871627 3792 471719 YDL150W RPC53
SGTC_2380 9035439 200 µM -0.749178010014109 0.227068273894582 no 2611 0.226874960619066 3848 6462575
SGTC_1939 st074455 53.6 µM -0.750635732904663 0.226633733832992 no 2612 0.226435955048034 3751 1644229
SGTC_847 0342-0274 5.54 µM -0.750715246362021 0.226610044767215 no 2613 0.226412022702739 3764 18097
SGTC_3027 9089541 49.47 µM -0.753591757010887 0.225754000048687 no 2614 0.225547197740774 3743 9943819
SGTC_2245 6637752 200 µM -0.753882048990906 0.22566771137883 no 2615 0.225460025228943 3798 681890
SGTC_1901 st060216 58.6 µM -0.755398837274298 0.225217152904939 no 2616 0.225004855339235 3765 688792
SGTC_2363 9053361 176 µM -0.757519450662673 0.224588084578751 no 2617 0.224369358683403 3800 6469797 YMR079W SEC14
SGTC_2740 felodipine 17.08 µM -0.758112742169181 0.224412266526195 no 2618 0.224191746096537 3689 3333 L-type calcium channel blocker
SGTC_2735 sertaconazole 140 nM -0.758463458984872 0.224308370643349 no 2619 0.224086790208515 3836 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_495 decylubiquinone 155 µM -0.760957494901635 0.223570328773904 no 2620 0.223341227773246 3769 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1706 st031321 9.9705 µM -0.763548201539932 0.222805144400796 no 2621 0.222568263678625 3797 6103185
SGTC_2416 tofa 880 nM -0.763778140136587 0.222737302512409 no 2622 0.222499732894415 3815 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3345 9148410 3.559 µM -0.765974220064781 0.222089956843591 no 2623 0.221845820887039 3732 4903596
SGTC_2841 9004761 38.96 µM -0.766365091346089 0.22197485112419 no 2624 0.221729548942664 3766 2991039
SGTC_995 3931-2021 34.6 µM -0.766836415410264 0.221836098581459 no 2625 0.221589391133345 3788 730143
SGTC_306 1672-3436 11.6 µM -0.767672507142364 0.221590084433907 no 2626 0.221340886849276 3787 6797378
SGTC_363 0455-0021 3.06 µM -0.768383223105513 0.221381083892221 no 2627 0.221129772290633 3788 4597466
SGTC_1861 st057647 17.4 µM -0.77014013585227 0.220864911841786 no 2628 0.220608385026385 3823 688668
SGTC_650 1328-0195 38 µM -0.770214449990943 0.220843093924784 no 2629 0.22058634685174 3726 2780821
SGTC_539 4859-0462 2.54 µM -0.770968564658882 0.220621762914516 no 2630 0.220362782285899 3847 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1956 st077085 54 µM -0.772768024943524 0.220094138949432 no 2631 0.219829839999803 3833 24208685
SGTC_2215 7188065 200 µM -0.774174779458117 0.219682165744078 no 2632 0.21941372028443 3785 940217
SGTC_2893 9048488 25.97 µM -0.77418467120413 0.219679270478613 no 2633 0.219410795897048 3803 6467338
SGTC_626 0214-0009 33 µM -0.774626645912641 0.219549929014473 no 2634 0.219280153726741 3836 3437874
SGTC_828 2074-0507 139 µM -0.774949722959206 0.219455409975466 no 2635 0.219184684503222 3852 X828
SGTC_704 1310-0270 142 µM -0.775512492620882 0.219290822588123 no 2636 0.219018443220397 3776 5718033
SGTC_3190 9110366 49.47 µM -0.776124938644018 0.219111787512491 no 2637 0.218837610043104 3734 17123768
SGTC_280 3448-3607 3.04 µM -0.776517599965535 0.218997045872405 no 2638 0.218721716554145 3779 626179
SGTC_1081 sertraline 6 µM -0.777168507054846 0.218806917017113 no 2639 0.218529679987154 3799 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_970 1315-0089 19.5 µM -0.778565703778523 0.218399119144264 no 2640 0.218117794245075 3754 6811083 YLR033W RSC58
SGTC_1350 1495-0454 146 µM -0.778855970576504 0.218314454328239 no 2641 0.21803228139358 3801 1069057
SGTC_1316 1272-0050 65.9 µM -0.779482397915441 0.218131802890703 no 2642 0.217847801230634 3777 7340392
SGTC_1980 st071811 45.7 µM -0.780681460340735 0.217782430320001 no 2643 0.217494933687922 3918 4974850
SGTC_2219 9098279 200 µM -0.780788446644018 0.217751273257416 no 2644 0.217463465134209 3768 902349
SGTC_909 3448-9333 149 µM -0.781362177227052 0.217584232570761 no 2645 0.217294755000259 3745 3344074
SGTC_653 0203-0016 55.2 µM -0.781876698514399 0.217434493487466 no 2646 0.217143520151422 3837 295302
SGTC_1371 2421-0008 32.7 µM -0.784735662273238 0.21660354508186 no 2647 0.2163042844779 3796 2827552
SGTC_4 0960-0234 25.671 µM -0.785186990159966 0.216472536210165 no 2648 0.216171971068945 3794 6821112
SGTC_1715 st032160 10.2275 µM -0.785941764104428 0.216253547245753 no 2649 0.215950802745645 3729 5289825
SGTC_2479 5617353 43.85 µM -0.786550272747031 0.2160770888975 no 2650 0.215772589440633 3823 2731746
SGTC_1820 st053765 18.6 µM -0.787409328627284 0.215828117650877 no 2651 0.215521143800317 3819 3690829
SGTC_2806 7952793 58.44 µM -0.788686718885819 0.215458212481381 no 2652 0.215147566101371 3847 2972490
SGTC_1458 k015-0034 6.33 µM -0.789134237749268 0.215328707532893 no 2653 0.215016776454696 3846 3598957
SGTC_339 3091-4833 71.4 µM -0.789197270480382 0.215310470477558 no 2654 0.214998358530971 3747 3240077
SGTC_260 nsc-65238 3.989 µM -0.789254714507908 0.215293851164302 no 2655 0.214981574403062 3743 3246252
SGTC_1734 st037168 69.4 µM -0.789256939473805 0.215293207467357 no 2656 0.214980924322723 3876 708907
SGTC_544 k015-0020 52.4 µM -0.791266006962853 0.214712427267474 no 2657 0.214394390248939 3827 3008304
SGTC_914 3820-6779 408 µM -0.791596733002463 0.214616908500927 no 2658 0.214297926235973 3788 2893481
SGTC_1973 st070275 50.2 µM -0.792739119036239 0.214287159905109 no 2659 0.2139649168082 3722 17118334
SGTC_2362 9071156 126 µM -0.793094825624906 0.214184545750944 no 2660 0.21386128865891 3827 653133
SGTC_676 falcarinol 140 µM -0.793864622819207 0.213962572748257 no 2661 0.213637123405699 3828 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_402 epigallocatechin gallate 10 µM -0.795628190011367 0.213454548737172 no 2662 0.213124088264419 3799 65064 An antioxidant.
SGTC_2231 micatex 6.853 µM -0.797072364667925 0.213039054983456 no 2663 0.212704502554994 3855 20737 An antifungal of unknown mechanism.
SGTC_1158 4092-0494 91.8 µM -0.798356901912229 0.212669886240902 no 2664 0.212331702982891 3944 1148199
SGTC_3020 9089140 49.47 µM -0.79940466876597 0.212369040774996 no 2665 0.212027902078228 3898 17217859
SGTC_496 calpeptin 138 µM -0.800255091065786 0.21212504182157 no 2666 0.211781508397002 3807 73364 A calpain inhibitor.
SGTC_873 0591-4978 488 µM -0.800706914205447 0.211995473667665 no 2667 0.211650669422443 3859 3305145
SGTC_1842 st055362 61.2 µM -0.800808558124807 0.211966331882578 no 2668 0.211621241890125 3818 676032
SGTC_663 1486-0733 13.9 µM -0.803240380239425 0.211269816055617 no 2669 0.210917905101128 3850 722445 YPR165W RHO1
SGTC_2432 5630864 12.22 µM -0.803337855328375 0.211241925486585 no 2670 0.210889741747653 3855 5714970
SGTC_2423 st077119 87.2 µM -0.804757978060316 0.210835830172164 no 2671 0.210479677647742 3776 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1505 k297-0037 20.6 µM -0.806041799398696 0.210469105655626 no 2672 0.210109374020869 3842 4089396
SGTC_2616 abietic acid 100 µM -0.807009809655124 0.210192840558245 no 2673 0.209830415751308 3835 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_706 4262-0057 46.9 µM -0.807092668474171 0.210169202981722 no 2674 0.209806547867068 3823 883298
SGTC_1453 4237-0541 195 µM -0.807409785555259 0.21007875172727 no 2675 0.209715215499807 3775 739892
SGTC_2698 st077697 67.5 µM -0.807671113362372 0.21000423043018 no 2676 0.209639968482761 3817 3154499
SGTC_215 1287-0124 461.5 µM -0.808163347098004 0.209863905253897 no 2677 0.209498277286699 3862 5560863
SGTC_299 1273-0059 1.44 µM -0.809437976699964 0.209500792203944 no 2678 0.209131632646855 3764 2848077
SGTC_1965 Pectolinarigenin 58.4 µM -0.809653262222485 0.209439498749495 no 2679 0.209069743516143 3832 5320438 An anti-inflammatory.
SGTC_2488 5268135 45.7 µM -0.810139388549562 0.209301133639385 no 2680 0.208930034199157 3907 1270356 YLR208W SEC13
SGTC_3157 9099274 49.47 µM -0.810706031341818 0.209139919222228 no 2681 0.208767254444778 3801 17217662
SGTC_38 0929-0051 58.268 µM -0.81112884353889 0.209019673407487 no 2682 0.208645841679826 3867 1379719
SGTC_7 0192-1582 4.227 µM -0.811251937774872 0.20898467363566 no 2683 0.20861050234128 3893 252616
SGTC_1283 0922-0125 16.4 µM -0.811934010347383 0.20879080035798 no 2684 0.208414748893891 3859 3360884
SGTC_2128 5255449 168.493 µM -0.812621677526055 0.208595444192009 no 2685 0.20821749952086 3844 736008
SGTC_1581 himbacine 57.9 µM -0.81268784706834 0.20857665207991 no 2686 0.208198525364605 3847 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1881 5652484 16 µM -0.813077624437438 0.20846597578826 no 2687 0.208086777176307 3795 2255129
SGTC_466 geldanamycin 89.2 µM -0.813122512513244 0.208453232157639 no 2688 0.208073910151871 3727 5288382 HSP90 inhibitor.
SGTC_3066 9117245 49.47 µM -0.813760956366221 0.208272029026871 no 2689 0.207890953093944 3920 17176980
SGTC_690 glyoxal 20.3 µM -0.815240353961471 0.207852503736357 no 2690 0.207467371555129 3712 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2144 5628481 200 µM -0.815725582774933 0.207715012057053 no 2691 0.207328551880277 3845 2818399
SGTC_2549 cedrol 20.94 µM -0.816329561946803 0.207543947031587 no 2692 0.207155835526399 3778 6708665 A sedative which affects the nervous system.
SGTC_2891 9063876 19.48 µM -0.817198915327777 0.207297866287208 no 2693 0.206907381148036 3858 6472478
SGTC_2316 5844804 197.44 µM -0.819989477382715 0.206509131336383 no 2694 0.206111052927266 3923 776813
SGTC_2533 agelasine 13.65 µM -0.821092263828181 0.206197926370776 no 2695 0.205796858126508 3906 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.822830000680762 0.205708103793875 no 2696 0.205302336808336 3830 7104
SGTC_1344 1488-0097 29.1 µM -0.823156352870381 0.205616190728674 no 2697 0.205209543018718 3900 747966
SGTC_638 3970-0837 4.09 µM -0.826059746789894 0.204799559414047 no 2698 0.204385100201391 3850 4118451 YLR208W SEC13
SGTC_2600 tangeritin 87.95 µM -0.828326664066221 0.204163291530141 no 2699 0.20374276309154 3825 68077 A bioactive flavone.
SGTC_559 1550-0661 158 µM -0.831608922252551 0.203244131735227 no 2700 0.202814862139648 3936 5830875
SGTC_607 4491-0986 66.8 µM -0.834960327233434 0.202308161205937 no 2701 0.201870023061785 3895 698981 YDR232W HEM1
SGTC_2166 5933061 31.504 µM -0.835164514277496 0.202251219890578 no 2702 0.201812543278013 3973 2877375
SGTC_2909 7941780 10.49 µM -0.835230902144789 0.20223270847733 no 2703 0.201793856837041 3828 1243215
SGTC_1084 voriconazole 435 nM -0.835234104729101 0.202231815503015 no 2704 0.20179295541987 3870 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2123 5259487 200 µM -0.836943322263488 0.201755572216735 no 2705 0.201312213669556 3889 2173474
SGTC_2793 7325131 81.82 µM -0.837967004927867 0.201470662982757 no 2706 0.201024617376152 3872 4176441
SGTC_2393 9031399 185.94 µM -0.839413890378881 0.201068380291803 no 2707 0.200618545910517 3919 1526623 YDL150W RPC53
SGTC_2608 thymoquinone 42.66 µM -0.840362398951288 0.2008049247251 no 2708 0.200352612421781 3873 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3224 9130643 49.47 µM -0.840445754594227 0.200781781960203 no 2709 0.2003292521155 3892 17644395
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.84061607005272 0.200734500749302 no 2710 0.200281526526321 3919 688664
SGTC_1008 4106-0037 6 µM -0.843406813935173 0.199960715702309 no 2711 0.19950048118631 3840 2905394
SGTC_502 l-744,832 89.3 µM -0.84438408034991 0.199690175181829 no 2712 0.199227407685172 3885 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2446 5162541 200 µM -0.844779294316961 0.199580829107632 no 2713 0.199117038645295 3856 1549321
SGTC_222 nsc-310342 10.666 µM -0.845130043561824 0.199483815525481 no 2714 0.199019117860332 3833 432556
SGTC_1204 4049-0315 18.3 µM -0.846645425543664 0.199065003024681 no 2715 0.198596393122502 4014 588402
SGTC_112 phenothiazine 287.218 µM -0.849580045963672 0.198255457477587 no 2716 0.197779304832674 3825 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1150 3909-7983 10.9 µM -0.85052256973743 0.197995874691045 no 2717 0.197517308898116 3882 23965914
SGTC_2399 5884133 200 µM -0.85179363544528 0.197646132613478 no 2718 0.197164319734653 3922 722445
SGTC_2505 galangin 7.89 µM -0.852386314240178 0.197483180879449 no 2719 0.196999856772429 3803 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1202 1988-0068 29.6 µM -0.852397380255653 0.197480139150172 no 2720 0.196996786843906 3861 2850480
SGTC_1701 st028638 40.4 µM -0.853532503388884 0.197168276964291 no 2721 0.196682035397716 3856 3490878
SGTC_2134 5324836 1.464 µM -0.853681988294658 0.197127229901303 no 2722 0.196640608340452 3876 699272
SGTC_532 1548-0774 215 µM -0.854521592331118 0.196896779112949 no 2723 0.196408025394014 4059 5932993
SGTC_1678 st019265 80.2 µM -0.856977076046135 0.196223745482549 no 2724 0.195728776926965 3899 5367020
SGTC_2930 9013230 14.89 µM -0.859756960548398 0.195463481347273 no 2725 0.194961514359791 3958 2995857
SGTC_2701 st077767 14.721 µM -0.860824090417433 0.195172110330391 no 2726 0.19466746738922 3898 5721188
SGTC_1213 1315-0166 115 µM -0.862889322014326 0.194608966143596 no 2727 0.194099161061548 4013 768401
SGTC_842 0271-0008 11.1 µM -0.863196715364813 0.194525231212704 no 2728 0.194014659666883 3974 1221709
SGTC_386 1509-0011 3.07 µM -0.864562932417221 0.194153334702084 no 2729 0.193639362485483 3952 3107280
SGTC_2326 6164455 177.58 µM -0.867335801514839 0.193399867565961 no 2730 0.192879022964212 3925 2888790
SGTC_824 1304-0008 100 µM -0.869595776305233 0.192787089855549 no 2731 0.192260673397946 3945 768245
SGTC_1266 0828-0227 32.9 µM -0.870129384347617 0.192642578734374 no 2732 0.192114850541067 3956 3913820
SGTC_670 4204-0025 119 µM -0.873924360591144 0.191616738347775 no 2733 0.191079723627744 3949 719039
SGTC_1208 2323-2347 50.3 µM -0.874364603966386 0.191497950773643 no 2734 0.190959863570036 3943 5412760
SGTC_2466 5983409 37.09 µM -0.874496989561034 0.191462238984962 no 2735 0.190923829470723 3952 2879657
SGTC_2105 5350118 200 µM -0.874915204067273 0.191349449984512 no 2736 0.190810022865669 3935 2133313
SGTC_2858 9025781 8.96 µM -0.875035635590876 0.191316978149652 no 2737 0.190777258163041 3876 4894980 YPL153C RAD53
SGTC_906 1165-0455 526 µM -0.876060795642181 0.191040701999983 no 2738 0.190498492044731 3908 3252859
SGTC_2425 5628681 7.85 µM -0.87615419315278 0.191015543946318 no 2739 0.190473107411816 3999 5714958
SGTC_692 k241-0027 77.8 µM -0.87665209547451 0.190881460602974 no 2740 0.190337816935217 3989 3600480
SGTC_2369 9071472 200 µM -0.877659218783913 0.190610422417663 no 2741 0.190064340961348 4024 17296037
SGTC_2686 alizarin 95.37 µM -0.877768779062064 0.190580951684014 no 2742 0.190034605348361 3960 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1928 4'-methoxychalcone 40.3 µM -0.878291591527683 0.190440358338879 no 2743 0.189892748876278 3999 641818
SGTC_994 3910-0338 138 µM -0.878487979894736 0.190387562558872 no 2744 0.189839478982767 4035 3479481
SGTC_1676 st018489 23.4 µM -0.87953447091107 0.190106382273583 no 2745 0.189555775662103 3989 3696235
SGTC_2103 5378138 10 µM -0.879909308607842 0.190005729735076 no 2746 0.189454220787641 3969 244142
SGTC_2348 9022543 33.42 µM -0.880106251442546 0.189952859185351 no 2747 0.189400876434456 3994 3162678 YDL140C RPO21
SGTC_2662 daunorubicin 22.37 µM -0.881454279243786 0.189591215449693 no 2748 0.189035995013307 3826 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2541 muurolladie-3-one 83.07 µM -0.881954563023777 0.189457109076877 no 2749 0.188900689454585 3982 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2275 7947463 200 µM -0.882119012754935 0.189413039333826 no 2750 0.18885622580657 3893 1225414
SGTC_1626 st003712 1.76 µM -0.882589763476548 0.189286920995988 no 2751 0.188728980657675 3961 24207035
SGTC_2880 9042983 58.44 µM -0.883753024299361 0.188975494771975 no 2752 0.18841477491791 3966 6464714
SGTC_1554 st069299 38.7 µM -0.884487051166005 0.188779144861566 no 2753 0.188216674716119 3898 24207999
SGTC_2766 oltipraz 83.91 µM -0.885626576332118 0.188474574626106 no 2754 0.187909392803934 3889 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_208 k072-0098 12.366 µM -0.88684436595699 0.188149421188722 no 2755 0.18758134888128 3936 5948901
SGTC_3162 9099653 49.47 µM -0.887201839374567 0.188054040490549 no 2756 0.187485121160278 3904 25237511
SGTC_590 k048-0076 22.4 µM -0.887621882415864 0.18794200317522 no 2757 0.187372089411136 3978 6832814
SGTC_1333 1482-0047 286 µM -0.890394190441199 0.18720358453365 no 2758 0.186627130376633 3940 3811116
SGTC_1953 st076800 12.1 µM -0.894127471203407 0.186212045002957 no 2759 0.185626846275009 3983 297591
SGTC_2888 9058547 12.99 µM -0.894493869743305 0.186114907189878 no 2760 0.185528854129674 3871 16476514
SGTC_2118 5526350 200 µM -0.895548065626554 0.185835599094148 no 2761 0.185247091845759 4015 743594
SGTC_1905 st060207 84.5 µM -0.895649558551812 0.185808722375861 no 2762 0.185219979154111 3920 1948547
SGTC_1061 3448-9325 110 µM -0.902610248276486 0.183971192252899 no 2763 0.183366392755541 3871 723482
SGTC_302 1094-0063 18.9 µM -0.902952435917294 0.183881151999648 no 2764 0.183275569657768 3933 5440289
SGTC_1256 0570-0116 285 µM -0.905077046603062 0.183322714995851 no 2765 0.182712285645015 3990 410638
SGTC_817 1391-0715 46 µM -0.90510671781704 0.183314923648229 no 2766 0.182704426772434 3984 1353946
SGTC_1643 st009866 20.2 µM -0.905334379374817 0.183255148996312 no 2767 0.18264413416643 3939 3156273 YOR207C RET1
SGTC_1550 gossypolone 36.6 µM -0.907186712460828 0.182769253666916 no 2768 0.182154034582092 3986 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_926 2268-1401 59.4 µM -0.907216167275655 0.182761533719887 no 2769 0.182146247925085 3945 2931578
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.907341373409681 0.182728720143847 no 2770 0.182113150829415 3995 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.909476262189721 0.18216978228099 no 2771 0.181549391198621 3931 260807
SGTC_737 1950-0117 57.9 µM -0.910157404837388 0.181991676594325 no 2772 0.181369752091047 3927 5393513
SGTC_1240 0356-0016 42.1 µM -0.911897855945766 0.181537076918344 no 2773 0.18091124516844 3969 4305613
SGTC_1640 st009078 66.4 µM -0.91249441261499 0.18138142212228 no 2774 0.180754254744335 3956 690618
SGTC_191 3914-0123 66.505 µM -0.912535331930994 0.181370748433254 no 2775 0.180743489508952 3940 3144412
SGTC_634 1611-4317 11.2 µM -0.91346166217176 0.181129223013206 no 2776 0.180499893991208 3974 2843522
SGTC_3034 9090421 49.47 µM -0.913661599210193 0.181077119157573 no 2777 0.180447343914915 3860 17173761
SGTC_1002 4049-0206 172 µM -0.913883269524706 0.181019362559435 no 2778 0.180389092834285 4000 4662749
SGTC_450 aminopyrene 156 nM -0.916818497403477 0.180255672333033 no 2779 0.179618879018036 3884 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2181 6316240 54.2555 µM -0.917716416828487 0.180022455323649 no 2780 0.179383675304524 4016 12779990
SGTC_158 k038-0087 26.446 µM -0.917825776808019 0.179994064155922 no 2781 0.179355042456849 3912 X158
SGTC_279 1273-0055 2.93 µM -0.919436060514327 0.179576340653789 no 2782 0.178933767499805 3997 2847562
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.924039308851285 0.178385576311771 no 2783 0.177732925029789 4032 65057 A dermal irritant. YDR527W RBA50
SGTC_2551 apiole 73.87 µM -0.924193764232951 0.178345708377999 no 2784 0.17769272084687 3831 10659 A possible DNA adduct former.
SGTC_1464 k208-0027 110 µM -0.924816426507218 0.178185044095246 no 2785 0.177530702285556 3969 X1464
SGTC_2569 tetrandrine 100 µM -0.925225865889199 0.178079447015407 no 2786 0.177424215780043 4021 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1530 rhein 70.4 µM -0.927522634205053 0.177487827147743 no 2787 0.176827622777065 4066 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1326 1431-2094 10.8 µM -0.928399430767553 0.177262302502185 no 2788 0.176600206849911 3992 616278
SGTC_1979 st071809 45.3 µM -0.931226218959102 0.17653644498201 no 2789 0.175868279025517 4100 4976333
SGTC_2520 obtusaquinone 4.71 µM -0.932006790275525 0.176336342983289 no 2790 0.175666508121324 4047 5967872
SGTC_2765 myclobutanil 7.74 µM -0.933021250755642 0.176076497283871 no 2791 0.175404498175173 4055 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3064 1327-0027 10 µM -0.935369899881579 0.175475840960409 no 2792 0.174798851753686 3904 16000455 YPR107C YTH1
SGTC_1431 4049-0260 9.09 µM -0.937518716024878 0.174927430164598 no 2793 0.174245900521108 3997 3854841
SGTC_2885 9057732 51.95 µM -0.938357415633723 0.17471367659479 no 2794 0.174030381286084 4095 6471414
SGTC_736 0958-0254 92.6 µM -0.94448643265528 0.173156653424126 no 2795 0.172460565857752 4115 6812352
SGTC_567 1080-0542 68.4 µM -0.945085076161138 0.173005048460957 no 2796 0.172307721875626 3899 5950415
SGTC_934 2950-0684 338 µM -0.945686532814684 0.17285281626343 no 2797 0.172154246708782 4080 1121253
SGTC_2794 7785382 27.27 µM -0.945735636947954 0.172840391490419 no 2798 0.172141720540099 3967 2205081
SGTC_326 k292-0812 17.5 µM -0.9470070313265 0.172518889923539 no 2799 0.171817598010605 4001 3579357
SGTC_3024 9090631 49.47 µM -0.947151768020319 0.172482314086953 no 2800 0.171780724332758 3989 25236383
SGTC_322 k048-0136 19.3 µM -0.947608937976741 0.172366816962413 no 2801 0.171664287150799 4095 6823282
SGTC_2153 5569715 200 µM -0.947652411186923 0.172355836678035 no 2802 0.171653217530904 4034 2054701
SGTC_2107 5363541 170.161 µM -0.948619538782881 0.172111678961997 no 2803 0.171407074944784 4003 244052
SGTC_507 nimesulide 162 µM -0.95208605022262 0.171238350155317 no 2804 0.170526671537531 4096 4495 A COX2 inhibitor.
SGTC_1950 st077106 7.18 µM -0.954716934530637 0.170577438079007 no 2805 0.169860431817905 4010 13831864
SGTC_2158 5657123 3.6195 µM -0.954991041467702 0.170508672947777 no 2806 0.169791113672607 3963 2858827
SGTC_1941 st076221 61.8 µM -0.955107771399355 0.170479394332292 no 2807 0.169761599671264 3960 2828568
SGTC_1736 st036774 51 µM -0.955131777418954 0.170473373456471 no 2808 0.169755530396067 4109 1272247
SGTC_1342 1486-1464 234 µM -0.956460881125758 0.170140237538665 no 2809 0.169419719484524 4081 3253938
SGTC_1125 tnp00248 1.32998 µM -0.956769904819207 0.170062841477179 no 2810 0.169341702783988 4139 24207736
SGTC_1804 st050076 49.1 µM -0.96026345959772 0.169189438433723 no 2811 0.168461317734124 4080 3895976
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.960590952876596 0.169107711670758 no 2812 0.168378939702937 4086 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_174 3553-0389 74.3 µM -0.960708160771348 0.169078468310038 no 2813 0.168349463392123 4115 738071
SGTC_2374 9071832 200 µM -0.963112155601234 0.168479388282601 no 2814 0.167745621124439 3951 17381698
SGTC_908 3448-7491 47.7 µM -0.963342132200683 0.168422149296541 no 2815 0.167687928129373 4047 1203031
SGTC_245 methotrexate 289.6 µM -0.965111651591816 0.167982151111233 no 2816 0.167244445796014 4026 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1410 3909-8106 77.9 µM -0.965515450957119 0.167881848529117 no 2817 0.167143350411302 4099 1039210
SGTC_3342 9147791 14.508 µM -0.966230274118478 0.167704383103281 no 2818 0.166964483600097 3949 1838168
SGTC_2024 5144227 134 µM -0.96849555237274 0.167142792633751 no 2819 0.166398469590383 4124 3475211
SGTC_444 curcumin 90.4 µM -0.972282736410876 0.166206614169829 no 2820 0.165454954923179 4010 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_547 1120-0019 610 nM -0.972819717808425 0.166074148965087 no 2821 0.165321455524448 4005 3676939
SGTC_3105 9121040 49.47 µM -0.973306009799655 0.16595424694492 no 2822 0.165200618220384 3903 41448907
SGTC_1299 1079-1439 3.74 µM -0.973638640441235 0.165872264485943 no 2823 0.16511799671746 4019 323161
SGTC_1443 4112-3303 14 µM -0.978042862924018 0.164789237771616 no 2824 0.164026562553868 4102 704433
SGTC_2669 eugenol 100 µM -0.97974001608551 0.164373122278335 no 2825 0.163607233999461 4056 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3102 9121669 49.47 µM -0.981504227105752 0.163941287995144 no 2826 0.163172075450724 4100 41905072
SGTC_751 0833-0568 350 µM -0.981695853369501 0.163894427088591 no 2827 0.163124854433232 4107 6954252
SGTC_1641 st009299 47.1 µM -0.982884708289801 0.163603894924737 no 2828 0.162832092361338 3970 4046054
SGTC_2368 9071271 200 µM -0.983564546933641 0.163437906452673 no 2829 0.162664832005814 4075 27209959
SGTC_1693 xanthone 101.9 µM -0.984751129648248 0.163148454206234 no 2830 0.162373165535006 4114 7020 An insecticide.
SGTC_774 k060-0086 136 µM -0.985711839879947 0.162914344981962 no 2831 0.162137268890523 4032 5911235
SGTC_518 1021-0119 62.6 µM -0.987059439860078 0.162586325372016 no 2832 0.161806750055791 4057 1097762
SGTC_2272 7805186 180 µM -0.988014191533939 0.162354189296864 no 2833 0.161572848982098 4093 2956062 YPR165W RHO1
SGTC_1605 st000082 49.1 µM -0.989114653060096 0.16208689344092 no 2834 0.161303524583129 4057 1114022
SGTC_2850 9015429 58.44 µM -0.990098742868001 0.161848106493558 no 2835 0.161062928886179 4118 6457570
SGTC_2031 5180455 200 µM -0.991210986029165 0.161578499520817 no 2836 0.160791283617295 4017 29949
SGTC_2347 9049783 174.81 µM -0.992479331491296 0.161271410969169 no 2837 0.160481878461888 4125 6467988 YPL169C MEX67
SGTC_3012 9080433 71.4286 µM -0.993694290692162 0.160977605411026 no 2838 0.160185861565691 4071 17688859
SGTC_2967 9089538 49.85 µM -0.996312951993443 0.160345540572576 no 2839 0.159549056319304 4100 728216
SGTC_1853 st056710 91.2 µM -1.00012150577754 0.159429170672287 no 2840 0.158625854876619 4155 269167
SGTC_2986 9022445 71.43 µM -1.00037028540041 0.159369431743809 no 2841 0.158565672293298 4108 6459286
SGTC_1521 st012942 49.4 µM -1.00636785688873 0.157933683890476 no 2842 0.157119324861553 4089 24207259
SGTC_204 PMA1.184 62.41 µM -1.01022820988408 0.157014067417274 no 2843 0.156192983393262 4106 2252213 YGL008C PMA1
SGTC_980 1473-0395 201 µM -1.01088122206635 0.156858855325955 no 2844 0.156036641249457 3977 768876
SGTC_635 k038-0028 24.7 µM -1.01139042330641 0.15673789521255 no 2845 0.155914801464569 4107 4035102
SGTC_1498 4478-3555 97.6 µM -1.01195012092704 0.156605010589761 no 2846 0.155780951464284 4063 3437919
SGTC_952 1185-0122 232 µM -1.0128765105438 0.156385228176042 no 2847 0.15555957471337 4039 678600
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.01670171343345 0.15547986550565 no 2848 0.154647675199398 4118 77254
SGTC_2462 5162487 171.77 µM -1.01717639611903 0.155367757585654 no 2849 0.154534761308924 3997 2259986
SGTC_1886 st057356 49.9 µM -1.02273819421582 0.15405817790388 no 2850 0.153215823751914 4067 24207747
SGTC_2207 7258803 200 µM -1.02380875715069 0.153806943975218 no 2851 0.152962806655176 4081 3666799
SGTC_701 4424-0219 185 µM -1.02978788303328 0.152408784193054 no 2852 0.15155479499873 4172 2911779
SGTC_255 tunicamycin 200.472 nM -1.03055351550503 0.152230359734334 no 2853 0.151375122114781 4047 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1908 st060353 56.5 µM -1.03120220205207 0.152079297145865 no 2854 0.1512230041187 4191 4227716
SGTC_1563 conessine 56.1 µM -1.03421211703714 0.151379667571641 no 2855 0.150518505362108 4200 441082 An anti-amoebic, histamine inhibitor.
SGTC_3153 9100258 49.47 µM -1.03537794520332 0.151109256548097 no 2856 0.150246220697988 4072 25236848
SGTC_79 0052-0007 94.094 µM -1.03805777754301 0.150488895084185 no 2857 0.149621578477343 4136 2801472
SGTC_514 4466-0038 2.65 nM -1.03960750981733 0.150130918797656 no 2858 0.149261143233205 3963 5722064
SGTC_2257 7960413 200 µM -1.04052768709203 0.149918633698796 no 2859 0.149047403835251 4145 2974689 YIL048W NEO1
SGTC_2294 7971431 200 µM -1.04595118311262 0.148671500353844 no 2860 0.147791785755265 4128 5741572
SGTC_2753 fluvastatin 17.09 µM -1.04902412574023 0.147967963593337 no 2861 0.147083507378392 4158 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1488 4013-0813 75.9 µM -1.04929778901583 0.147905417830541 no 2862 0.147020541652851 4070 2910057
SGTC_2029 5175081 200 µM -1.05017538264354 0.14770496313882 no 2863 0.146818742750593 4107 1380876
SGTC_2848 9016370 25.97 µM -1.0503992902272 0.147653848652342 no 2864 0.146767285925093 4138 7894410
SGTC_230 MPP+ 141.667 µM -1.05093666733047 0.147531222477383 no 2865 0.146643839166822 4132 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3202 9113761 49.47 µM -1.05240641901439 0.147196182682878 no 2866 0.146306562453241 4139 4798415
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.05383223619037 0.146871645831859 no 2867 0.145979865921629 4203 1273210
SGTC_1077 5-fluorocytosine 377 nM -1.05863494195756 0.145782013076947 no 2868 0.14488303357443 4197 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_497 capsazepine 133 µM -1.06188954019714 0.145046709745176 no 2869 0.144142917056854 4115 2733484 A calcium channel blocker.
SGTC_2417 cerulenin 830 nM -1.06237225795716 0.144937863474958 no 2870 0.144033361413384 4184 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2926 9010726 65.15 µM -1.06319955080289 0.144751448133322 no 2871 0.143845733039915 4192 2994293
SGTC_36 0335-0881 14.2 µM -1.06426049628349 0.144512619854126 no 2872 0.143605354136209 4055 23828853
SGTC_1531 st059297 52.4 µM -1.06634096655498 0.14404505863624 no 2873 0.143134768522303 4164 7566702
SGTC_2043 5101342 149 µM -1.06743073459659 0.143800553675585 no 2874 0.142888687974787 4166 678451
SGTC_1636 st007707 68.9 µM -1.06820946766461 0.143626005470676 no 2875 0.142713017504257 4208 403051
SGTC_2270 7924575 90.91 µM -1.06842542510732 0.143577625280785 no 2876 0.142664326624054 4153 1262135
SGTC_227 fluconazole 33.516 µM -1.07082275185077 0.143041299386577 no 2877 0.142124567380638 4160 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1364 1653-0028 37.6 µM -1.07145347846145 0.142900419495581 no 2878 0.141982788942617 4154 5718652
SGTC_256 clotrimazole 625 nM -1.07162824330161 0.142861400397312 no 2879 0.141943521220609 4100 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2058 5236698 133 µM -1.07573912043424 0.141945656755747 no 2880 0.141021973142942 4153 766665
SGTC_2286 7945697 125 µM -1.07663912686259 0.141745701771171 no 2881 0.140820758570527 4203 1245733
SGTC_1098 clofazimine 15.1 µM -1.07716690521156 0.141628533710204 no 2882 0.140702853735341 4225 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1188 1403-0014 4.57 µM -1.07755322746031 0.141542810845128 no 2883 0.140616592442914 4157 9614867
SGTC_1906 st060206 94.7 µM -1.08172497912097 0.1406193607749 no 2884 0.139687375179684 4198 5133468
SGTC_2862 9027634 71.43 µM -1.08180154668457 0.140602450244786 no 2885 0.139670359604301 4130 5012562
SGTC_2163 5671233 125 µM -1.0827671232548 0.1403893137587 no 2886 0.13945590090246 4149 701023
SGTC_769 0302-0231 76 µM -1.08542065676296 0.139804716527231 no 2887 0.138867693761073 4096 571869 YER009W NTF2
SGTC_1635 st007035 42.4 µM -1.08702584113918 0.139451884401793 no 2888 0.138512694780465 4161 3716403
SGTC_2557 derrustone 83.84 µM -1.08746659859165 0.13935510853816 no 2889 0.138415326156127 4170 629853 An antioxidant.
SGTC_3041 9091929 49.47 µM -1.09006429183601 0.138785668705892 no 2890 0.137842412202026 4186 25236887
SGTC_1991 st073000 8.92 µM -1.09046773696274 0.138697371955322 no 2891 0.137753578868046 4250 4301969 YIL048W NEO1
SGTC_3111 9122088 49.47 µM -1.09070830355757 0.138644740510409 no 2892 0.137700627849645 4023 16876704
SGTC_2552 juarezic acid 87.02 µM -1.09162362681262 0.138444609382515 no 2893 0.137499283388415 4146 1549512
SGTC_1795 st049545 62.3 µM -1.09187373324584 0.138389959050073 no 2894 0.137444302236324 4141 5291882
SGTC_3189 9110682 49.47 µM -1.09259325097952 0.138232820452471 no 2895 0.137286213635026 4251 17122418
SGTC_2943 9068529 45.32 µM -1.09328719546239 0.138081382186179 no 2896 0.137133861538531 4182 3270634
SGTC_2699 st077704 54.6 µM -1.09343039991622 0.13805014502207 no 2897 0.137102436087941 4195 645852
SGTC_3219 9131112 49.47 µM -1.09361089425503 0.138010780687073 no 2898 0.137062834580762 4098 17612988 YMR079W SEC14
SGTC_80 0159-0065 512.242 µM -1.09773305401651 0.137113855109235 no 2899 0.136160535906025 4089 1548079
SGTC_1005 4092-0690 4.4 µM -1.09969963759043 0.136687359625571 no 2900 0.135731506361164 4217 1529343
SGTC_846 0335-0850 148 µM -1.09991088829105 0.136641599426522 no 2901 0.13568547507765 4158 6819598
SGTC_2628 lathosterol 100 µM -1.10065602052441 0.136480275798482 no 2902 0.135523197010331 4261 6710616
SGTC_687 k029-0044 34.9 µM -1.10245571248956 0.136091173919811 no 2903 0.135131801090308 4268 5829338
SGTC_389 tpck 16.7 µM -1.10362401877665 0.135838987433731 no 2904 0.134878133840602 4209 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3063 1327-0034 4 µM -1.10523591950609 0.135491573853797 no 2905 0.134528688187303 4102 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1106 tegaserod maleate 11.7 µM -1.10609567894305 0.135306518769977 no 2906 0.134342554405996 4221 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1142 3253-1408 9.78 µM -1.10741998794374 0.13502181288675 no 2907 0.134056194015047 4218 256655
SGTC_2656 pseudo-anisatin 100 µM -1.10793845173629 0.13491046320893 no 2908 0.13394419892445 4223 6708809 A neurotoxin.
SGTC_778 3456-2434 196 µM -1.10884648057639 0.134715599045351 no 2909 0.133748207543119 4159 5539063
SGTC_3147 9097027 49.47 µM -1.10942256606385 0.134592070542453 no 2910 0.13362396597009 4193 25236841
SGTC_773 4358-1457 44.6 µM -1.10951834871818 0.134571539658907 no 2911 0.133603316684425 4209 1186886
SGTC_151 3013-0144 2.285 µM -1.11006621439999 0.134454146699096 no 2912 0.133485247334116 4066 906558 YHR107C CDC12
SGTC_1354 1498-1681 81 µM -1.11024773169531 0.134415267909103 no 2913 0.133446144765636 4209 5754243
SGTC_2935 9038016 29.96 µM -1.11154157365525 0.134138366350276 no 2914 0.133167652760221 4188 6463195
SGTC_719 2810-4230 27.3 µM -1.11165656516198 0.134113775420303 no 2915 0.133142920870505 4203 721079
SGTC_1278 0874-0585 172 µM -1.11406391883484 0.133599673941365 no 2916 0.132625883100787 4281 766306
SGTC_320 4092-0846 5.34 µM -1.11497018723647 0.13340648770458 no 2917 0.132431598741472 4159 1359356
SGTC_311 1315-0136 58 µM -1.11593235555077 0.133201595866197 no 2918 0.132225545393699 4230 6759207
SGTC_1837 st055472 66.5 µM -1.11644010091824 0.133093559827949 no 2919 0.13211689821949 4291 676091
SGTC_2586 curcumin 80 µM -1.11823414091161 0.132712314240062 no 2920 0.131733503248195 4127 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_435 c-PAF 6.7 µM -1.11945523196329 0.132453254775934 no 2921 0.131472989715445 4198 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1970 st070122 35.8 µM -1.11979178398181 0.132381915186198 no 2922 0.131401250625086 4238 102928
SGTC_3072 9116419 49.47 µM -1.12058404821432 0.13221408194296 no 2923 0.131232479087314 4255 17170162
SGTC_569 4130-2812 160 µM -1.1205852825766 0.132213820570174 no 2924 0.131232216255007 4045 743552
SGTC_1179 1021-1431 9.29 µM -1.12190807957516 0.131933926690581 no 2925 0.130950762504427 4228 2840958
SGTC_2565 isoliquiritigenin 100 µM -1.12860801150011 0.130522550538746 no 2926 0.129531614781838 4313 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_953 1188-0045 9.7 µM -1.12919490810981 0.130399416905363 no 2927 0.12940781063095 4236 6144426
SGTC_2591 skatole 100 µM -1.13118710062594 0.129982045048192 no 2928 0.128988175021731 4255 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1748 st037455 53.6035 µM -1.13284513346035 0.129635386694702 no 2929 0.128639647083688 4273 580690
SGTC_854 0422-0053 192 µM -1.13358836635377 0.129480201027971 no 2930 0.128483627612011 4235 3596728
SGTC_746 1095-0025 46.6 µM -1.13564491203807 0.129051469049119 no 2931 0.128052602195032 4241 6749286
SGTC_3318 9139014 38.6185 µM -1.14292867937123 0.127540929911896 no 2932 0.126534101985909 4233 16643984
SGTC_2282 7944268 200 µM -1.14321706435665 0.127481377451269 no 2933 0.126474239500911 4257 2970414
SGTC_156 3474-0145 5.642 µM -1.14579542621265 0.12694979636395 no 2934 0.125939904055532 4078 2265471
SGTC_2837 9008476 45.46 µM -1.14693726696595 0.126714876581936 no 2935 0.12570377452359 4246 2992805
SGTC_853 0419-0306 21 µM -1.14792868136114 0.126511150850581 no 2936 0.125499003403057 4259 762713
SGTC_1731 st035964 63 µM -1.15078494999402 0.125925492253217 no 2937 0.124910358918863 4168 6739575
SGTC_3236 9132701 49.47 µM -1.1526216126801 0.125549897219002 no 2938 0.124532864141143 4237 24282524
SGTC_203 k066-0004 30.888 µM -1.15286230952917 0.125500733038362 no 2939 0.124483452170915 4326 6795412
SGTC_1661 st013063 9.66 µM -1.15464387112898 0.125137253152978 no 2940 0.124118146676027 4300 721395
SGTC_1491 4138-0063 26.5 µM -1.15546626144368 0.124969714703241 no 2941 0.123949770521615 4218 23883227
SGTC_152 4469-0003 551.229 µM -1.15859539283651 0.124333676512775 no 2942 0.123310573859637 4221 697280
SGTC_1915 st067105 30.6 µM -1.15911478922769 0.124228321657461 no 2943 0.123204699165846 4190 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2078 5212016 200 µM -1.1591366330997 0.124223892194571 no 2944 0.123200247868088 4126 1899708
SGTC_3124 9127567 49.47 µM -1.15920358219665 0.124210317059746 no 2945 0.123186605825633 4235 17592030
SGTC_2748 diazoxide 86.69 µM -1.1595503979283 0.124140010537702 no 2946 0.123115953037516 4313 3019 A potassium channel activatior.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.1602314862993 0.124002021266885 no 2947 0.122977285390843 4228 364106
SGTC_1146 3579-1023 7 µM -1.16091154454716 0.123864347828337 no 2948 0.122838936760617 4279 X1146
SGTC_98 0074-0023 107.663 µM -1.16095747762654 0.12385505282927 no 2949 0.122829596234889 4256 3563821
SGTC_2781 5567276 71.43 µM -1.16398828680316 0.123242818195689 no 2950 0.122214379316671 4281 2853274
SGTC_1138 3761-0006 1.03 µM -1.16563565848575 0.12291093409879 no 2951 0.121880892138438 4286 12061087
SGTC_787 4152-0075 138 µM -1.16871589856731 0.122292062753562 no 2952 0.121259057139504 4267 9566539
SGTC_1747 st037496 66.6 µM -1.17002891117531 0.122028922775272 no 2953 0.120994667199399 4232 723305
SGTC_1766 st045414 44.774 µM -1.17786318838428 0.120467124706014 no 2954 0.119425576326282 4275 253960
SGTC_1300 1094-0077 113 µM -1.17962019163548 0.12011879947066 no 2955 0.119075654257308 4233 5532636
SGTC_398 bronopol 33.3 µM -1.18166051348113 0.119715197813238 no 2956 0.118670216017397 4192 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2395 5646831 180.19 µM -1.18373800200243 0.11930522771626 no 2957 0.118258395435839 4285 6808628
SGTC_394 menadione 8.33 µM -1.18408071284561 0.11923769272399 no 2958 0.118190557073286 4265 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_334 1502-1024 68.5 µM -1.18519432527188 0.119018429288101 no 2959 0.117970311556383 4277 3296216
SGTC_883 0850-0245 24.6 µM -1.18544078393278 0.118969941594197 no 2960 0.1179216072774 4344 6823229 YPR165W RHO1
SGTC_2217 6934799 96.0675 µM -1.18550609792602 0.118957094212163 no 2961 0.117908702544544 4248 675606
SGTC_682 0kpi-0099 17 µM -1.18642325310245 0.118776791574891 no 2962 0.117727596624261 4290 1714895 YML126C ERG13
SGTC_1449 4112-4002 201 µM -1.1879153766746 0.118483869135848 no 2963 0.117433375498179 4325 2059539
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.18891192417083 0.11828851903869 no 2964 0.117237163679513 4177 17037758
SGTC_726 3448-4391 34.2 µM -1.189183433973 0.118235335313901 no 2965 0.117183745959894 4379 1356692
SGTC_2063 5246145 200 µM -1.18974854824696 0.118124694153351 no 2966 0.117072618840501 4312 711240
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.19211745075655 0.117661694332031 no 2967 0.116607597680137 4217 1241132 A phosphatase inhibitor.
SGTC_2813 7971799 71.43 µM -1.19230379648423 0.117625327802611 no 2968 0.116571073223495 4280 2234054
SGTC_1393 3470-5649 58.2 µM -1.19249760220824 0.117587513849671 no 2969 0.116533095187662 4247 4108395
SGTC_1312 1218-2183 165 µM -1.19288907916113 0.117511157984002 no 2970 0.116456408401655 4336 6744073
SGTC_1951 sophoraflavanone G 9.2 µM -1.19644343138893 0.116819503114434 no 2971 0.115761780664432 4241 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_642 0335-0876 158 µM -1.1964939370865 0.116809695857921 no 2972 0.11575193157543 4316 6812350
SGTC_2333 9017922 200 µM -1.19686983172824 0.116736722525456 no 2973 0.11567864726067 4316 3163164
SGTC_2151 5563267 85.4165 µM -1.2002226900691 0.116087253700114 no 2974 0.115026432693462 4339 5310824
SGTC_3216 9129716 49.47 µM -1.20487277280048 0.115190756097861 no 2975 0.114126210480928 4220 8056934
SGTC_2382 9035899 200 µM -1.2060648395086 0.114961730195477 no 2976 0.113896245329579 4276 6462679
SGTC_1507 4075-3230 155 µM -1.20834866835961 0.114523854415775 no 2977 0.113456587780249 4236 659771
SGTC_2214 7179297 48.276 µM -1.21040431009591 0.114130744953661 no 2978 0.113061894419899 4352 769744
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.21405493978139 0.113434989824316 no 2979 0.112363372650606 4319 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3007 9078383 71.4286 µM -1.21460605106234 0.113330219648097 no 2980 0.112258189939122 4273 6496995
SGTC_1441 4106-0040 13 µM -1.21734304338349 0.112810920521108 no 2981 0.111736861903832 4303 2904180
SGTC_2411 st077133 39.94 µM -1.21740648332297 0.11279890401784 no 2982 0.111724798764908 4314 1403142 YNL221C POP1
SGTC_1114 scopoletin 1.73284 µM -1.21751949917533 0.11277749933602 no 2983 0.111703311047367 4325 5280460 A coumarin with genotoxic properties.
SGTC_1787 fluconazole 80 µM -1.2183192855421 0.112626106359394 no 2984 0.111551332054419 4042 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_181 1447-1644 8.07 µM -1.21976021050144 0.112353717544425 no 2985 0.111277894554992 4279 534600
SGTC_293 4049-0273 38.5 µM -1.2200808332759 0.112293171901383 no 2986 0.111217116808906 4173 1380311
SGTC_1968 st069590 43.6 µM -1.22665346405225 0.111057146491935 no 2987 0.109976432678653 4267 6384066
SGTC_1346 1488-2224 62.4 µM -1.22676583266045 0.111036099906795 no 2988 0.109955308087943 4311 3722427
SGTC_2470 5664817 21.68 µM -1.22684698212883 0.111020902427707 no 2989 0.109940054309652 4340 2859561
SGTC_947 3447-0010 211 µM -1.22769092284062 0.110862939528433 no 2990 0.109781507609772 4271 748350
SGTC_3154 9100113 49.47 µM -1.22777381276848 0.110847433461904 no 2991 0.109765944371057 4310 25237525
SGTC_449 xestospongin c 11.1929 µM -1.23267113737514 0.109934056120874 no 2992 0.108849242187303 4316 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2287 7945887 168.79 µM -1.23625430547965 0.109269205965231 no 2993 0.108182025224078 4328 1245853
SGTC_852 0418-0143 439 µM -1.23759006735698 0.109022098497859 no 2994 0.107934049622336 4312 5369229
SGTC_2135 5326629 150.42 µM -1.23907283722594 0.108748266170556 no 2995 0.107659262616455 4265 5020077
SGTC_1904 st060225 78 µM -1.23943160681738 0.108682084337384 no 2996 0.107592851210999 4277 66595
SGTC_2936 9038235 15.59 µM -1.240476595685 0.10848948145813 no 2997 0.107399582807211 4260 4749415
SGTC_922 1866-0035 480 µM -1.2413487830569 0.108328915890261 no 2998 0.107238465356032 4245 3156169
SGTC_2598 perillyl alcohol 100 µM -1.24328143324698 0.107973733610763 no 2999 0.106882071793536 4347 10819 An apoptosis inducer.
SGTC_346 4513-0042 7.16 µM -1.24383710339865 0.107871767986085 no 3000 0.106779760863244 4275 2827372
SGTC_2705 st078069 42.8 µM -1.24399486002177 0.107842832246024 no 3001 0.106750727330369 4355 1530061
SGTC_1022 4477-0945 21.3 µM -1.24869622742562 0.10698307116277 no 3002 0.105888100617469 4277 4648966
SGTC_762 1165-0429 115 µM -1.25336834393082 0.106133568533445 no 3003 0.105035843253207 4327 5967793
SGTC_162 k030-0015 37.8 µM -1.25337331209447 0.106132667803574 no 3004 0.10503493964324 4397 1809920 YMR134W ERG29
SGTC_1496 4469-0713 57.4 µM -1.25825804990567 0.105249733115316 no 3005 0.104149223588725 4310 746691
SGTC_3203 9113543 49.47 µM -1.26027376894965 0.104886937641862 no 3006 0.103785309613827 4371 17018012
SGTC_304 1310-0298 97 µM -1.26106959198648 0.104743952481208 no 3007 0.103641887549064 4110 1550234
SGTC_2226 7298446 200 µM -1.26117651808207 0.104724751880975 no 3008 0.103622628448847 4347 3283010
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.26213190923823 0.104553306480639 no 3009 0.103450662470644 4334 5024745
SGTC_1660 st012960 28.1 µM -1.26699683871692 0.103683445882074 no 3010 0.10257821013014 4372 24207266
SGTC_2001 4023502 57.655 µM -1.2670617579107 0.103671873789799 no 3011 0.102566604118956 4351 108941 YCR052W RSC6
SGTC_184 1494-0393 24.714 µM -1.26728858706669 0.103631447990555 no 3012 0.102526059943708 4309 3090647
SGTC_759 3486-0358 89.3 µM -1.26746113275323 0.103600704325346 no 3013 0.102495226374657 4337 875103
SGTC_1878 temozolomide 1 mM -1.26827880813334 0.103455103408507 no 3014 0.102349201093583 4277 5394 DNA alkylating agent.
SGTC_3018 9082602 49.47 µM -1.27075913000862 0.103014348895198 no 3015 0.101907176272708 4273 17332089
SGTC_154 3389-1638 511.116 µM -1.27119659944183 0.102936752059108 no 3016 0.101829358025642 4343 5238686
SGTC_445 e6 berbamine 66 µM -1.27798559092638 0.101737982429949 no 3017 0.100627253445648 4362 6610268 A calcium/calmodulin antagonist.
SGTC_2844 9010103 25.97 µM -1.27848482686161 0.101650232443823 no 3018 0.100539265691372 4336 2480525
SGTC_1082 camptothecin 424.86 nM -1.2840143374012 0.100682001629454 no 3019 0.0995684694337492 4231 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1222 0366-0074 1.18 µM -1.28578993655097 0.100372521244827 no 3020 0.0992581916429348 4381 286520
SGTC_331 k048-0133 24.5 µM -1.28632847154351 0.10027879393066 no 3021 0.0991642250041683 4309 6813582
SGTC_2304 7443016 91.4 µM -1.28696080534256 0.100168823311428 no 3022 0.0990539748753597 4292 939854
SGTC_506 n9-isopropylolomoucine 153 µM -1.287854746899 0.10001350613578 no 3023 0.0988982653121629 4360 6610355
SGTC_2710 st078562 53.7235 µM -1.29104320314017 0.0994609625683429 no 3024 0.0983443484763504 4296 17250908
SGTC_876 0720-0963 56.8 µM -1.29113275014259 0.099445476795913 no 3025 0.0983288247274342 4381 765861
SGTC_2162 5663267 200 µM -1.29148574401303 0.0993844491190532 no 3026 0.0982676476616596 4359 6456493
SGTC_551 k048-0028 34.9 µM -1.29435079952339 0.0988901339327891 no 3027 0.0977721384857525 4330 6836383
SGTC_935 2996-0153 430 µM -1.29468690307522 0.0988322632457791 no 3028 0.0977141298875596 4367 23738523
SGTC_1771 st048882 4.1505 µM -1.29480546877931 0.0988118543836282 no 3029 0.0976936724830427 4397 4580403
SGTC_2182 6325192 200 µM -1.29680434800606 0.0984682489461559 no 3030 0.0973492571421495 4371 736248
SGTC_3006 9075424 71.4286 µM -1.29858438159521 0.0981630000047255 no 3031 0.0970433003963699 4325 7465181
SGTC_2965 9082772 38.63 µM -1.29858763970727 0.0981624419238973 no 3032 0.0970427410315787 4368 16459634
SGTC_1434 4073-0095 163 µM -1.30236991046596 0.0975161446801251 no 3033 0.0963949817199671 4358 24133745
SGTC_2921 7974240 10.71 µM -1.30566400991173 0.0969558112251848 no 3034 0.095833421078433 4457 2979074 YDR527W RBA50
SGTC_942 3253-1115 227 µM -1.30759627208259 0.0966282310818185 no 3035 0.095505141007475 4391 46497897
SGTC_2822 7994718 71.43 µM -1.30876973287811 0.0964296891933702 no 3036 0.0953061812202238 4358 1018011
SGTC_1196 1588-0294 184 µM -1.31196679374222 0.0958902885547736 no 3037 0.094765669421456 4392 6144269
SGTC_689 0833-0039 98 µM -1.31393433722705 0.0955594342074243 no 3038 0.0944341511016514 4325 5374726
SGTC_1090 efavirenz 20.7 µM -1.31443473728899 0.0954754230645665 no 3039 0.0943499734995334 4403 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2916 7875993 68.79 µM -1.31714960021003 0.0950205776550771 no 3040 0.0938942419553216 4239 1299250
SGTC_1408 3909-7976 48.8 µM -1.31807687147059 0.0948655898239451 no 3041 0.0937389580143586 4420 24152374
SGTC_2825 7998094 58.44 µM -1.3201270905348 0.0945235693595489 no 3042 0.0933962946551193 4358 2987815
SGTC_2299 7976368 114.88 µM -1.32036912628563 0.094483252683295 no 3043 0.0933559031545576 4409 2979718
SGTC_1009 4106-0057 9.87 µM -1.32074839906096 0.0944201014952811 no 3044 0.0932926351706066 4378 2928005
SGTC_1048 3161-0300 24.5 µM -1.32271768470654 0.0940927039394534 no 3045 0.0929646400900376 4385 2165101
SGTC_2116 5511452 16.8835 µM -1.32304201605055 0.0940388636540699 no 3046 0.0929107028267204 4395 870744
SGTC_1474 0330-0125 5.35 µM -1.3283901260107 0.0931543316557728 no 3047 0.0920246298461312 4430 X1474
SGTC_2871 9038510 12.99 µM -1.33418770242362 0.0922024235408754 no 3048 0.0910711743866951 4372 4945164
SGTC_1495 4469-0029 237 µM -1.33838296080848 0.091518104812557 no 3049 0.0903858152351142 4407 793680
SGTC_2737 bleomycin 30.5 nM -1.33888113536056 0.0914370946674444 no 3050 0.0903046859401057 4495 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1697 st025554 27.742 µM -1.34052512894252 0.0911701354554546 no 3051 0.0900373401306647 4412 1269519
SGTC_3108 9121785 49.47 µM -1.34250459238364 0.0908494685691955 no 3052 0.0897162211745457 4250 17140271
SGTC_2067 5224629 34.075 µM -1.34324723301351 0.0907293792335141 no 3053 0.0895959660071651 4390 2835000
SGTC_592 k241-0073 46.5 µM -1.34549720820046 0.0903662642451575 no 3054 0.089232361131936 4431 4230158
SGTC_2480 5767542 37.17 µM -1.34705864596256 0.0901149047853289 no 3055 0.0889806727509248 4325 2867358
SGTC_2030 5175110 200 µM -1.35194470866095 0.0893317049241476 no 3056 0.0881965018526586 4406 2831986
SGTC_3194 9111903 49.47 µM -1.3521452258871 0.0892996720036323 no 3057 0.0881644309605637 4413 17087251
SGTC_646 4092-0839 27.3 µM -1.35384427546582 0.089028589259103 no 3058 0.0878930323924698 4431 877796
SGTC_3330 9141424 71.43 µM -1.35472968299902 0.0888875658024534 no 3059 0.0877518485467427 4418 27261020
SGTC_1368 1852-0141 284 µM -1.35760374113847 0.0884309457600248 no 3060 0.087294727615328 4399 2838987
SGTC_3333 9141820 12.094 µM -1.35861063888652 0.08827138757319 no 3061 0.0871350010671709 4398 1939433
SGTC_2865 9030313 51.95 µM -1.3586190100163 0.0882700619409405 no 3062 0.0871336740506546 4390 42562754
SGTC_3000 9075062 71.4286 µM -1.36410807906748 0.0874040171159347 no 3063 0.0862667762123886 4386 17057871
SGTC_2812 7970281 58.44 µM -1.36543408917929 0.0871957585238982 no 3064 0.0860583278661921 4442 2233435
SGTC_2068 5226020 147 µM -1.3656340635141 0.0871643834218865 no 3065 0.0860269246961746 4423 1810509
SGTC_837 0091-0265 12.5 µM -1.36647644028825 0.0870323107241628 no 3066 0.0858947353406558 4403 759367
SGTC_3300 9124615 50.48 µM -1.36766231440048 0.0868466359315854 no 3067 0.0857089006338418 4448 24824903
SGTC_641 4092-0595 30 µM -1.36898579454747 0.0866397655213064 no 3068 0.0855018576977265 4466 786260
SGTC_1949 st076024 69.1 µM -1.37433135461543 0.085807959370256 no 3069 0.0846694182405043 4370 2921930
SGTC_1330 1469-0054 61.8 µM -1.37708680992473 0.0853815331117452 no 3070 0.0842427051005371 4398 7102664
SGTC_1967 st070177 51.4 µM -1.38386483349942 0.0843393433755589 no 3071 0.0831999232434413 4429 5729214
SGTC_1143 3454-2408 5.08 µM -1.38450604352872 0.0842412472663302 no 3072 0.0831017794306483 4427 X1143
SGTC_2384 9036245 200 µM -1.3886861257219 0.0836038513177372 no 3073 0.0824641074741511 4360 6462766
SGTC_1817 st052116 64.4 µM -1.39038201829428 0.0833462905277414 no 3074 0.0822064519326798 4463 4361398
SGTC_1873 rapamycin 2 nM -1.39085513195273 0.0832745437184682 no 3075 0.0821346804573853 4378 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2456 5770359 74.46 µM -1.3908902023396 0.0832692272084039 no 3076 0.0821293621495632 4427 3118787
SGTC_1893 st059353 36.1 µM -1.39186370141447 0.0831217510415385 no 3077 0.0819818377670723 4432 3112488
SGTC_2526 patulin 37.61 µM -1.39505489740829 0.0826396913585113 no 3078 0.0814996428126453 4447 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2211 7117706 200 µM -1.39669000446311 0.0823935100170024 no 3079 0.0812534056417146 4372 822771
SGTC_2322 7413319 38.22 µM -1.39823910377864 0.0821607877545961 no 3080 0.0810206388807433 4396 1840400
SGTC_1244 0416-0015 52.5 µM -1.39922997252006 0.0820121887183995 no 3081 0.0808720156535725 4409 96201
SGTC_468 gf-109203x 121 µM -1.40493033786699 0.0811612449005476 no 3082 0.0800209970906735 4500 2396 A protein kinase C inhibitor.
SGTC_1509 1326-1131 80 µM -1.40526108243907 0.0811120770034649 no 3083 0.0799718282115211 4419 768313
SGTC_229 benomyl 22.8748 µM -1.40542698345395 0.081087422921699 no 3084 0.079947173775194 4455 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1422 4031-0024 15.5 µM -1.40767552387097 0.0807538312003451 no 3085 0.0796135863286649 4384 782427
SGTC_2237 6667747 47.222 µM -1.40889909648644 0.0805727388393579 no 3086 0.0794325033836841 4437 729940 YDL015C TSC13
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.40978136245497 0.0804423513232636 no 3087 0.0793021257492442 4472 94937 An inhibitor of serotonin biosynthesis.
SGTC_3011 9081274 71.4286 µM -1.40981734344551 0.0804370371827443 no 3088 0.0792968120666386 4439 6625322
SGTC_297 0986-0032 24 µM -1.41199614794502 0.0801157370839431 no 3089 0.0789755477017349 4413 2847425
SGTC_588 3970-1144 52.9 µM -1.41416817402468 0.0797964031792303 no 3090 0.0786562650538258 4329 1888707
SGTC_1031 k035-0009 16 µM -1.41703741461018 0.079376041024033 no 3091 0.0782359944305505 4475 5180959
SGTC_972 1319-0219 195 µM -1.41776532513482 0.0792696644888795 no 3092 0.0781296454131466 4431 23903702
SGTC_805 3852-0218 479 µM -1.41884826692257 0.0791116036090641 no 3093 0.0779716286810075 4427 6615355
SGTC_553 k007-0256 45.7 µM -1.42141115807869 0.078738487471316 no 3094 0.0775986322680019 4497 6287000
SGTC_1012 4112-3522 18 µM -1.42209165126563 0.0786396428862436 no 3095 0.0774998230630091 4455 3112398
SGTC_827 3253-0474 693 µM -1.42296569415989 0.0785128223708777 no 3096 0.077373050195612 4452 5402065
SGTC_941 3237-0776 460 µM -1.42438318876326 0.0783074786340048 no 3097 0.0771677889937384 4474 760008
SGTC_718 1130-0073 349 µM -1.43260089401645 0.0771250468412139 no 3098 0.0759859630618116 4474 6740020
SGTC_2718 lomofungin 53.02 µM -1.43496401654477 0.0767875455113657 no 3099 0.0756486758673147 4432 5351222 A RNA synthesis inhibitor.
SGTC_1603 st002045 67.8 µM -1.44078132582608 0.075961502736514 no 3100 0.074823235375156 4449 5887985
SGTC_836 0330-0104 1.35 µM -1.4417409051893 0.0758258975056772 no 3101 0.0746877396987033 4488 46494820
SGTC_1839 st053978 48 µM -1.44174268615252 0.0758256459961639 no 3102 0.0746874883951962 4502 3788398
SGTC_866 0495-0101 262 µM -1.44998384478539 0.0746686110232457 no 3103 0.0735315121667547 4472 635694
SGTC_571 k831-0106 44.2 µM -1.45068893371068 0.0745702477009244 no 3104 0.0734332491627105 4366 4783639
SGTC_3353 9151644 39.2805 µM -1.45121704505093 0.074496638413989 no 3105 0.0733597160127719 4475 4909158
SGTC_2649 anisomycin 9.56 µM -1.45879297338214 0.0734467851981403 no 3106 0.0723110485810049 4518 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1220 1838-0075 193 µM -1.46909895355911 0.072036822001669 no 3107 0.0709029757819927 4413 5529645
SGTC_218 alverine citrate 93.75 µM -1.47268266446423 0.0715514266636717 no 3108 0.0704183115666726 4528 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_467 ro 31-8220 72.8 µM -1.47463282530619 0.071288343854375 no 3109 0.0701556424288377 4446 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1590 st077108 57.8 µM -1.47517399578962 0.071215470043916 no 3110 0.0700828853793447 4492 5489485
SGTC_2401 5128683 200 µM -1.4763133557008 0.0710622312539943 no 3111 0.0699298951996199 4475 708373
SGTC_491 tetrandrine 80.3 µM -1.47854679069942 0.0707625791500689 no 3112 0.0696307413645997 4498 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2047 4141938 200 µM -1.48444268357143 0.0699762124601473 no 3113 0.0688457590931436 4501 3807862
SGTC_54 0159-0055 9 µM -1.48851672992364 0.0694367754545735 no 3114 0.0683073367275354 4475 3319099
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.49148186532245 0.0690461851876304 no 3115 0.0679175144500945 4499 23847180
SGTC_1501 4491-0275 38.4 µM -1.49470743026531 0.0686232144049096 no 3116 0.0674954071378784 4497 5104718
SGTC_313 3474-0040 5.03 µM -1.49709290309606 0.0683116930883706 no 3117 0.0671845430682504 4515 1043375 YIL048W NEO1
SGTC_477 mead ethanolamide 10 µM -1.50231904405629 0.0676330214222571 no 3118 0.0665073663276013 4495 16061185
SGTC_1534 6-azauridine 81.6 µM -1.50326047315813 0.0675113221577472 no 3119 0.0663859443343377 4526 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1975 st070967 30.8 µM -1.51098090145869 0.0665196715362752 no 3120 0.0653966584418244 4488 261391
SGTC_1811 st050069 61.5 µM -1.51335801678727 0.0662166242078792 no 3121 0.0650943715564864 4497 3877702
SGTC_1814 st052110 31.539 µM -1.51427597641207 0.066099884431901 no 3122 0.0649779294778252 4439 674163
SGTC_868 0527-0199 213 µM -1.52284617705614 0.0650176650502608 no 3123 0.0638985970404357 4489 2849450
SGTC_1387 3342-1166 1.8 µM -1.52612034654276 0.0646078621732664 no 3124 0.0634899478861213 4494 3418228
SGTC_1564 D-Arginine 115 µM -1.53200662044879 0.0638761710490114 no 3125 0.0627604005217089 4502 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_585 0kpi-0023 191 µM -1.53316015884399 0.0637335390521404 no 3126 0.0626181990337216 4453 64601
SGTC_3327 9140648 26.9345 µM -1.53885335309965 0.0630332165515344 no 3127 0.0619200506421152 4528 8029710
SGTC_743 1275-0778 158 µM -1.53928872886881 0.0629799084626373 no 3128 0.0618669121726302 4484 2849257 YMR203W TOM40
SGTC_85 0868-0259 160.055 µM -1.54293751673961 0.0625345246378029 no 3129 0.061422968495017 4462 83173
SGTC_570 0987-0065 62.6 µM -1.5435858050016 0.0624556498171217 no 3130 0.0613443530123747 4378 3104428
SGTC_111 0083-0039 52.457 µM -1.5491788044988 0.0617783879582841 no 3131 0.0606693715894424 4494 759313
SGTC_1241 0364-0022 50.8 µM -1.5508193518464 0.0615808237644197 no 3132 0.0604724908293861 4524 4563895
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.55823492434143 0.0606939469339616 no 3133 0.0595887844475221 4467 6708739 YPR165W RHO1
SGTC_978 1416-0512 87.4 µM -1.55899499188115 0.0606036128306438 no 3134 0.0594987827524077 4564 6814003
SGTC_3311 9131146 2.8755 µM -1.57173467451232 0.0591051046525481 no 3135 0.0580060485360364 4489 4900406 YPR165W RHO1
SGTC_3125 9127534 49.47 µM -1.5732329897111 0.0589307918411742 no 3136 0.0578324395682855 4460 1639235
SGTC_2690 usnic acid 100 µM -1.57340636758869 0.0589106472599356 no 3137 0.0578123767645747 4536 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2588 indole-3-carbinol 100 µM -1.57874464904535 0.0582930386378659 no 3138 0.0571973195591136 4508 3712 Induces cell cycle arrest.
SGTC_137 0438-0332 85.389 µM -1.58061007489793 0.0580784227035779 no 3139 0.0569836103949216 4484 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1843 st055809 45.5 µM -1.58306418406383 0.0577970254739045 no 3140 0.0567034179694872 4568 16413835
SGTC_2050 5263056 171 µM -1.58394979977315 0.057695741110897 no 3141 0.0566025716832415 4515 763468 YGL055W OLE1
SGTC_546 peri-Naphthalide 147 µM -1.58504689199424 0.0575704646178611 no 3142 0.0564778402911552 4494 223824 A penicillin ester.
SGTC_2534 helenine 20.12 µM -1.5870999436584 0.0573366024252415 no 3143 0.0562450053322933 4543 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.5874242778637 0.0572997261295388 no 3144 0.0562082921657799 4522 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2707 st078556 66.6 µM -1.58754701598171 0.0572857758647485 no 3145 0.0561944036944966 4462 17250899
SGTC_186 3455-3465 67.277 µM -1.58774328693362 0.0572634735020393 no 3146 0.056172200214836 4550 755278
SGTC_3309 9129340 25.759 µM -1.58911840760742 0.0571074094650803 no 3147 0.0560168313477232 4521 17158987
SGTC_1652 st011932 78 µM -1.58953445221229 0.0570602581121688 no 3148 0.0559698911358013 4473 1551076
SGTC_1369 1866-0067 208 µM -1.59041951804746 0.0569600533883869 no 3149 0.0558701368378268 4553 3531355
SGTC_128 0906-2981 13.371 µM -1.5927098447584 0.0567013920417575 no 3150 0.055612648999488 4531 6740226
SGTC_1468 k284-1086 134 µM -1.59794501988093 0.0561136248950356 no 3151 0.0550276067897431 4550 15996457
SGTC_82 0054-0107 293.755 µM -1.59833990005949 0.056069486239473 no 3152 0.0549836760547356 4521 3104697
SGTC_1923 st058458 19.1 µM -1.59970537315689 0.0559170683064664 no 3153 0.0548319796584372 4525 3534982
SGTC_1821 st053465 65.6 µM -1.60118501753567 0.0557522754407314 no 3154 0.0546679731273291 4563 675086
SGTC_1774 st048371 48.465 µM -1.60346971278178 0.0554985744134368 no 3155 0.0544154953490406 4540 4242727
SGTC_2482 5981709 142.65 µM -1.60383285764826 0.0554583335395089 no 3156 0.0543754499178646 4489 877755
SGTC_1282 0886-0010 32.4 µM -1.60854042177149 0.0549387604629508 no 3157 0.0538584353526184 4560 2836211 YNL267W PIK1
SGTC_1272 0839-0021 27 µM -1.60990607803869 0.0547887552390268 no 3158 0.0537091809529702 4589 5027250
SGTC_960 1222-0186 7.7 µM -1.61236284304913 0.0545197166858022 no 3159 0.0534415027643561 4534 3126296
SGTC_3247 9135149 49.47 µM -1.61284371850366 0.0544671788357505 no 3160 0.0533892326323642 4597 8934436 YOR116C RPO31
SGTC_1508 1080-0625 72.9 µM -1.61363715998166 0.0543805792671197 no 3161 0.053303075828488 4495 767111
SGTC_967 1306-0166 352 µM -1.61643292607413 0.0540763052781683 no 3162 0.0530003721593162 4553 4437607
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.61930342227404 0.0537653017634144 no 3163 0.0526909973572991 4538 5282362
SGTC_2673 kobusone 100 µM -1.62242374157392 0.0534288397913874 no 3164 0.0523563245477667 4657 6710676 An epoxy ketone and protein crosslinker.
SGTC_2638 epoxomicin 18 µM -1.62337593065025 0.0533264988082653 no 3165 0.0522545333927807 4514 9915668 A protesome inhibitor.
SGTC_1174 0739-0097 51.1 µM -1.62398199603727 0.0532614400505138 no 3166 0.0521898255324217 4575 728447
SGTC_1170 0310-0127 64.8 µM -1.62888249908345 0.0527376985542629 no 3167 0.0516689478047387 4565 774975
SGTC_319 1348-1596 45.5 µM -1.62986778362361 0.0526328912502242 no 3168 0.0515647219389333 4609 5380505
SGTC_1413 3910-0535 34.4 µM -1.63513098200006 0.0520758279885694 no 3169 0.0510107963019369 4588 2876951
SGTC_2905 7799065 20.05 µM -1.63553555403315 0.0520332021835903 no 3170 0.0509684138744855 4449 1296806
SGTC_2764 methyldopa 94.69 µM -1.63710359258907 0.0518682551239583 no 3171 0.0508044130335449 4523 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.64573541002807 0.050967673316538 no 3172 0.0499091226698614 4517 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2769 toremifene 3.73 µM -1.64628966950147 0.0509102738182926 no 3173 0.0498520676656453 4557 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1147 3809-1045 12.3 µM -1.64796295267165 0.0507372995899253 no 3174 0.0496801368657119 4581 325925
SGTC_1228 0124-0032 52.5 µM -1.6485696735075 0.0506746960745182 no 3175 0.0496179129544705 4577 X1228
SGTC_2247 cerulenin 830 nM -1.64899955651238 0.0506303765353762 no 3176 0.0495738627842475 4581 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_618 k072-0232 33.2 µM -1.64995933018789 0.0505315384033502 no 3177 0.0494756272684655 4596 5872756 YGL099W LSG1
SGTC_3325 9138760 55.175 µM -1.65281691650519 0.0502381721514424 no 3178 0.049184065089504 4511 43844959
SGTC_716 1683-5115 658 µM -1.65422596276693 0.0500940168556878 no 3179 0.0490408047717826 4572 723597
SGTC_3242 9133940 49.47 µM -1.65655874998361 0.049856081556768 no 3180 0.0488043589740472 4569 17248444
SGTC_533 1222-0222 6.71 µM -1.66014704137561 0.0494918503316529 no 3181 0.0484424377137277 4590 3982874
SGTC_1079 idarubicin 2.36 µM -1.66072849703202 0.0494330298657853 no 3182 0.0483839936915284 4586 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1525 8-methoxypsoralen 92.5 µM -1.66266328124135 0.0492377074136072 no 3183 0.0481899280991358 4591 4114 Related to psoralen; DNA damaging agent.
SGTC_1760 st045453 10.4495 µM -1.66645569511776 0.0488566397022445 no 3184 0.0478113428088325 4577 3323419 YIL048W NEO1
SGTC_1708 st033234 31.827 µM -1.67581546604383 0.047926237276585 no 3185 0.0468871718807835 4650 674664
SGTC_2929 9013348 24.6 µM -1.68094600704293 0.0474222889195606 no 3186 0.0463867012577986 4549 2995952
SGTC_1088 bifonazole 369 nM -1.6855491499203 0.0469737661723144 no 3187 0.0459413352366403 4588 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1055 3448-0672 86 µM -1.68843739676474 0.0466940813119974 no 3188 0.0456636484185354 4549 748378
SGTC_2650 prasterone 100 µM -1.69244897200457 0.046307836713656 no 3189 0.0452802008459985 4612 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1345 1488-0192 31.4 µM -1.69298617751154 0.0462563085347502 no 3190 0.0452290491417168 4626 658348
SGTC_2810 7959871 45.46 µM -1.69448943905804 0.0461123619403484 no 3191 0.0450861584203234 4529 2974535
SGTC_779 1360-0071 233 µM -1.70116135508041 0.0454778214675834 no 3192 0.0444563461593566 4596 7566
SGTC_1529 apigenin 74 µM -1.70345841126459 0.0452609891104506 no 3193 0.0442411572959306 4583 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2276 7947513 42.08 µM -1.70630544049882 0.044993396722395 no 3194 0.0439756128381901 4521 2105100
SGTC_2675 theaflavin digallate 100 µM -1.70650211313488 0.0449749585751328 no 3195 0.0439573166060305 4533 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1674 st016616 23.6 µM -1.70657709444382 0.0449679306455864 no 3196 0.0439503427965733 4557 625830
SGTC_3228 9131799 49.47 µM -1.70856621673867 0.0447818145933474 no 3197 0.0437656654803118 4617 17015818
SGTC_220 paclitaxel 373.376 µM -1.71219663396326 0.0444437270871247 no 3198 0.043430218781589 4577 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_734 2023-0417 80 µM -1.71324619522312 0.0443463694332389 no 3199 0.0433336281512973 4598 3935732
SGTC_2132 5317594 122.667 µM -1.71447589237774 0.0442325210416192 no 3200 0.0432206804430841 4529 794577
SGTC_887 0885-0007 9.62 µM -1.71672075927222 0.0440252934230723 no 3201 0.0430151026380256 4604 5719458
SGTC_2553 4-methylesculetin 85.09 µM -1.71835665534882 0.0438747746523679 no 3202 0.0428657906388387 4584 5319502
SGTC_478 N-arachidonylglycine 10 µM -1.72228038669092 0.0435154436636276 no 3203 0.0425093694415566 4638 5283389
SGTC_358 0075-0058 9.45 µM -1.72260864864439 0.0434854897860242 no 3204 0.0424796599716915 4552 1069125
SGTC_2957 9076800 11.52 µM -1.7266142223085 0.0431213204841399 no 3205 0.0421184849840521 4582 16459615
SGTC_1386 3228-0095 33.8 µM -1.73268889485498 0.0425737425714994 no 3206 0.0415754896988411 4600 870181
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.73611300029094 0.0422675761830575 no 3207 0.0412719280687773 4612 75037 A free radical scavenger.
SGTC_471 1-acyl-paf 4 µM -1.7400454783959 0.0419181540318933 no 3208 0.0409255163123278 4576 16759367
SGTC_3349 9149703 23.001 µM -1.74016782630478 0.0419073203787813 no 3209 0.0409147766399285 4614 4910494
SGTC_772 k072-0172 35.3 µM -1.74117154589086 0.0418185286548832 no 3210 0.0408267566419458 4643 5861980
SGTC_3062 9077494 49.47 µM -1.74250717202192 0.0417006118903252 no 3211 0.0407098687935125 4533 16459633
SGTC_603 3794-0023 45.9 µM -1.7436632032604 0.0415987683514019 no 3212 0.0406089176505875 4646 3802260
SGTC_809 3998-0021 90 µM -1.75545417201284 0.0405714800370117 no 3213 0.0395908264693898 4561 715485
SGTC_193 1273-0060 1.558 µM -1.75973075271364 0.0402040105526408 no 3214 0.0392267345015825 4487 2847393 YHR072W ERG7
SGTC_1302 1159-0335 255 µM -1.76364443745735 0.0398700968473199 no 3215 0.0388959305803547 4650 649284
SGTC_2621 lithochol-11-enic acid 100 µM -1.77001590427039 0.0393313115018222 no 3216 0.0383622456641645 4563 6708711
SGTC_1813 st051246 8.6015 µM -1.77867027794426 0.0386089827053449 no 3217 0.0376469173859071 4584 5291959
SGTC_2998 9066762 71.4286 µM -1.77987383954506 0.0385093902462944 no 3218 0.0375483049371653 4617 4945196
SGTC_428 3448-4153 16.5 µM -1.78118238781221 0.0384013480077726 no 3219 0.0374413299493379 4598 3834874
SGTC_2437 5741531 144.16 µM -1.7828635416507 0.0382629038269889 no 3220 0.0373042595791641 4624 2262990
SGTC_350 k064-0020 19.8 µM -1.78421148251296 0.0381521941751017 no 3221 0.0371946535895053 4626 2790705
SGTC_3182 9108849 49.47 µM -1.78468120839206 0.038113675886166 no 3222 0.0371565203474897 4608 17133045
SGTC_2519 cryptotanshinone 88.04 µM -1.78670789645496 0.0379478476582033 no 3223 0.0369923560783375 4631 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_171 k064-0041 9.68 µM -1.79602307741157 0.0371932132571046 no 3224 0.036245423437076 4604 53325
SGTC_1540 guanosine 70.6 µM -1.79663728692259 0.0371438893976115 no 3225 0.0361966104437929 4577 6802 Guanosine is a purine nucleoside
SGTC_3181 9108277 49.47 µM -1.80366356607792 0.0365834411390062 no 3226 0.0356420322240464 4624 17097298
SGTC_2291 7917025 104.35 µM -1.81303157569922 0.0358469861883944 no 3227 0.0349134756859644 4534 2964612
SGTC_2799 7812892 81.82 µM -1.81349078876396 0.0358112002949479 no 3228 0.0348780790167724 4632 20205235
SGTC_2334 9017922 200 µM -1.82612269132202 0.034838234139912 no 3229 0.0339158914644831 4632 3163164
SGTC_2007 4011539 71.82 µM -1.83273858136801 0.0343373725726174 no 3230 0.0334207283971154 4609 45595301
SGTC_1112 tnp00069 1.16933 µM -1.83338009901331 0.0342891222658393 no 3231 0.0333730325216981 4621 145826
SGTC_1547 harmine 94.2 µM -1.83381811069897 0.0342562102257493 no 3232 0.0333404992198609 4564 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1471 k673-0312 37 µM -1.83611525805921 0.0340840283212287 no 3233 0.0331703060687921 4646 24099884
SGTC_1855 st056195 39.6 µM -1.84101388540955 0.033719229619492 no 3234 0.0328097619552792 4581 4028379
SGTC_2942 9052777 62.25 µM -1.85002448519728 0.0330566053315351 no 3235 0.0321550103129128 4641 6469503
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.85697713656327 0.0325526844471792 no 3236 0.0316572034872497 4647 390807
SGTC_535 2293-4129 48.2 µM -1.86285273715194 0.0321317825303588 no 3237 0.031241493953666 4634 396118 YIL048W NEO1
SGTC_894 0960-0238 55.9 µM -1.86725569052296 0.0318193278850721 no 3238 0.0309329449505513 4640 6741907 YDL195W SEC31
SGTC_216 k038-0035 28.382 µM -1.87239032045264 0.031458124587533 no 3239 0.0305763116000672 4609 4444231 YPR107C YTH1
SGTC_3106 9121286 49.47 µM -1.87248019488631 0.0314518325462855 no 3240 0.0305700996921281 4597 15943471
SGTC_2094 5332512 191.667 µM -1.88781753537433 0.0303932148108249 no 3241 0.029525225126993 4669 755774
SGTC_2544 sphondin 68.51 µM -1.89112554771533 0.0301688020816992 no 3242 0.0293037934530124 4613 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2180 6301957 200 µM -1.89514300335578 0.0298981100971715 no 3243 0.0290367293895014 4676 845462
SGTC_2056 5235370 200 µM -1.89889624129529 0.0296470439786994 no 3244 0.0287890598228292 4580 5511916
SGTC_2954 9074818 52.69 µM -1.899880155378 0.0295815170365565 no 3245 0.0287244244138713 4644 16648742
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.91028724392306 0.0288957550458615 no 3246 0.0280481196389522 4631 6728940
SGTC_1357 1503-1303 39.5 µM -1.91135993837368 0.0288258285377743 no 3247 0.0279791706365321 4638 292895
SGTC_781 4335-2806 94.4 µM -1.9142038574767 0.0286411205416717 no 3248 0.0277970565364836 4681 845254
SGTC_2308 7584454 197.62 µM -1.91440435333877 0.0286281358843571 no 3249 0.0277842548748739 4630 893577
SGTC_1753 st043925 64 µM -1.91790609676829 0.0284021418112052 no 3250 0.0275614595209446 4676 670181
SGTC_3152 9099253 49.47 µM -1.91991356819646 0.0282732552361988 no 3251 0.0274344088923011 4511 25236131
SGTC_110 0850-0284 111.64 µM -1.93731967504597 0.0271760054004576 no 3252 0.0263531393274972 4634 3906265
SGTC_3289 9119912 71.43 µM -1.94157404204311 0.0269132889481666 no 3253 0.0260943439363554 4649 17014829
SGTC_2431 5490079 200 µM -1.94485222188604 0.0267123034209011 no 3254 0.0258963834012594 4683 5722345
SGTC_284 0988-0104 32.6 µM -1.94802404199228 0.0265190335471964 no 3255 0.0257060432382383 4648 4666532
SGTC_2962 9082311 13.18 µM -1.94931505585108 0.0264407028998019 no 3256 0.0256289058356097 4658 16459453
SGTC_1385 3091-4834 14.1 µM -1.95337077624717 0.0261958839232557 no 3257 0.025387838231256 4666 4072814
SGTC_2101 5377231 179.231 µM -1.95794291602861 0.0259221675092501 no 3258 0.0251183556714895 4698 2844213
SGTC_621 3584-0052 32.1 µM -1.96260868058634 0.0256453170600481 no 3259 0.0248458306492188 4701 2273927
SGTC_2021 4019055 173 µM -1.96752554849113 0.0253562500608991 no 3260 0.0245613267471674 4459 44827708 YER133W GLC7
SGTC_3103 9120822 49.47 µM -1.98690306281841 0.0242434702703233 no 3261 0.023466570079946 4673 17141819
SGTC_2507 purpurin 79.67 µM -2.01027124806895 0.0229563553571865 no 3262 0.0222012441035946 4668 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2857 9024691 58.44 µM -2.02022035357157 0.0224260953875786 no 3263 0.0216802679864605 4679 16478292
SGTC_1619 st003326 88.7 µM -2.02598630982025 0.0221235409538574 no 3264 0.0213830937872112 4667 2849032
SGTC_352 k048-0007 5.11 µM -2.04371081848069 0.0212149791681668 no 3265 0.0204910619111815 4625 6811911
SGTC_2379 9035213 200 µM -2.06512345562694 0.0201596471207515 no 3266 0.0194556603077693 4682 646551
SGTC_3286 9117135 37.221 µM -2.06696539153354 0.0200709829120167 no 3267 0.0193687075837043 4654 3438150
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.07158867646948 0.0198498903961509 no 3268 0.0191519084173138 4687 756377
SGTC_2164 5685496 200 µM -2.08868167187096 0.0190503382533586 no 3269 0.018368193891362 4666 759046
SGTC_2022 5136654 200 µM -2.09286413922656 0.0188589208866614 no 3270 0.0181806421276163 4669 1713771
SGTC_365 0121-0052 13.6 µM -2.09436375212288 0.0187906883759777 no 3271 0.0181137945951268 4668 3101739
SGTC_1684 st024538 14.6195 µM -2.10303736369728 0.0184001461689502 no 3272 0.0177312517479215 4714 6732859
SGTC_2777 climbazole 1.536 µM -2.10329462584658 0.0183886689320062 no 3273 0.017720011471052 4494 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2451 5856223 45.7 µM -2.12946945132884 0.0172523708704854 no 3274 0.0166077198619572 4690 2179896
SGTC_1261 0712-0010 12.7 µM -2.13938918680593 0.0168376930906788 no 3275 0.0162020809758062 4696 2840123
SGTC_2049 5262831 67.185 µM -2.14514918233515 0.0166008407340416 no 3276 0.0159704605869573 4681 763417
SGTC_2674 ligustilide 100 µM -2.15120795608135 0.0163547852502643 no 3277 0.0157298946737463 4751 5319022 A signalling regulator.
SGTC_3347 9188721 44.724 µM -2.16581007136179 0.0157745733517106 no 3278 0.0151628517107582 4700 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1658 st012944 20 µM -2.16990913165099 0.0156149064604511 no 3279 0.015006865211604 4591 24207260
SGTC_70 0141-0289 43.283 µM -2.17101134109284 0.0155722104329118 no 3280 0.0149651575491601 4697 352408
SGTC_1556 plumbagin 1.48 µM -2.17270686195601 0.0155067270496487 no 3281 0.0149011934995877 4670 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2373 9071805 200 µM -2.17481758268329 0.0154255384506517 no 3282 0.014821894476943 4713 10149009
SGTC_1392 3455-1037 33.9 µM -2.17497596174128 0.0154194611669078 no 3283 0.0148159588969541 4728 981132
SGTC_2436 5633522 8.09 µM -2.17729212034949 0.0153308206490707 no 3284 0.0147293893640596 4699 5724242
SGTC_722 3534-0461 190 µM -2.17842839029593 0.0152874952745053 no 3285 0.0146870790781472 4722 658262
SGTC_826 1683-5028 118 µM -2.18135972662519 0.0151762102385385 no 3286 0.0145784099830301 4738 722377
SGTC_1656 st012921 11 µM -2.18284456269734 0.0151201060757413 no 3287 0.0145236293574572 4645 6732821
SGTC_2093 5331342 194.4 µM -2.18457109593375 0.0150550936245229 no 3288 0.0144601545711922 4723 33839
SGTC_2719 novobiocin 32.65 µM -2.20246489732443 0.0143953315837212 no 3289 0.0138162430317325 4732 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1304 1165-0502 251 µM -2.22041671422897 0.013758599255538 no 3290 0.0131952467488494 4727 767425
SGTC_3303 9125618 40.5795 µM -2.23409496395554 0.0132898938595609 no 3291 0.012738412653676 4707 22695467
SGTC_1284 0929-0043 16 µM -2.24044580270299 0.013077003538655 no 3292 0.0125309977851507 4740 1239883
SGTC_268 camptothecin 39.6153 µM -2.24939728324937 0.0127819441924848 no 3293 0.0122436156508027 4689 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2607 solasodine 47.35 µM -2.25103821303278 0.0127284850165928 no 3294 0.0121915585990136 4677 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1274 0865-0114 173 µM -2.25451530952457 0.0126158450804884 no 3295 0.0120818843242316 4742 870624
SGTC_1978 st071761 42 µM -2.26226665737025 0.0123678428807354 no 3296 0.0118404665737057 4742 5147680
SGTC_1178 0988-0033 191 µM -2.26753485786094 0.0122017085988442 no 3297 0.0116787859966929 4752 5392207
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.26843505641644 0.0121735148929964 no 3298 0.0116513515588437 4731 4000243
SGTC_2989 9073649 71.4286 µM -2.28493830427736 0.0116665590052721 no 3299 0.0111582228074407 4694 21367202
SGTC_804 1595-0054 20.9 µM -2.28707811837026 0.011602188324993 no 3300 0.01109563191786 4733 761523 Stimulates phospholipase C.
SGTC_1066 ketoconazole 628 nM -2.30483261835973 0.0110798824331506 no 3301 0.0105879747651207 4755 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1852 st056254 31.4 µM -2.32481184779182 0.0105166948760676 no 3302 0.0100410116042924 4741 442583
SGTC_53 0973-0023 39.979 µM -2.32660860085637 0.0104672911962058 no 3303 0.00999305317889481 4690 674768
SGTC_2449 5812982 45.77 µM -2.32716561350479 0.0104520166533221 no 3304 0.00997822621116089 4690 776185
SGTC_3260 9137109 49.47 µM -2.32980433544753 0.0103799206461623 no 3305 0.00990824746443153 4740 17478346
SGTC_3137 9097352 49.47 µM -2.33107687432778 0.010345307144336 no 3306 0.00987465323324037 4699 44120435
SGTC_2179 6298986 200 µM -2.33990123531998 0.0101080381023218 no 3307 0.00964442000582982 4728 738374
SGTC_2076 5212012 200 µM -2.34208147454926 0.0100501525925628 no 3308 0.00958826409298011 4760 604802
SGTC_927 2425-1185 123 µM -2.34693511787819 0.00992232591558914 no 3309 0.00946427529670342 4721 730375
SGTC_2340 7987427 183.45 µM -2.3500248252311 0.00984169608754974 no 3310 0.00938607950496252 4713 2239331
SGTC_2795 7780010 54.55 µM -2.35144252519399 0.00980489132433941 no 3311 0.00935038921960634 4712 953673
SGTC_2877 9040724 71.43 µM -2.40640311349902 0.00846771374993008 no 3312 0.00805523835880613 4721 6463895
SGTC_886 0866-0150 153 µM -2.41963227270263 0.00817081614334683 no 3313 0.00776810460660038 4763 271463
SGTC_73 0327-0325 16.231 µM -2.4231901563302 0.00809254503495207 no 3314 0.00769243556936765 4618 53298
SGTC_3341 9147222 25.867 µM -2.43511831788628 0.00783492056428971 no 3315 0.00744346050037507 4763 1939759
SGTC_3132 9126706 49.47 µM -2.446331215455 0.00759935197686389 no 3316 0.00721591762005689 4750 850858
SGTC_2784 7567673 72.73 µM -2.44798089999363 0.00756522576328515 no 3317 0.0071829635423739 4703 3471247
SGTC_3067 9117431 49.47 µM -2.46534274208014 0.00721417373705646 no 3318 0.00684411231707108 4747 17150885
SGTC_2013 4024628 200 µM -2.48809744870949 0.00677587415081445 no 3319 0.00642142686189528 4748 5230760
SGTC_589 1227-0070 34.1 µM -2.52238859611293 0.00615977469549271 no 3320 0.00582804321278556 4780 2841384
SGTC_1058 3448-5425 97.3 µM -2.54789200615305 0.00573427715770882 no 3321 0.0054188007460124 4750 7279705
SGTC_608 k048-0125 159 µM -2.55126889192552 0.00567993918836196 no 3322 0.00536657408865743 4779 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_806 3966-4455 5.86 µM -2.57713269070048 0.00527869754458376 no 3323 0.00498118496361536 4768 714982
SGTC_1168 k815-0004 80.5 µM -2.61809731045018 0.0046946331804955 no 3324 0.0044210792894923 4761 642433
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.62237894854154 0.00463704480022327 no 3325 0.00436591405380464 4750 5377381
SGTC_2928 9011484 9.79 µM -2.67481233096544 0.00398124337874287 no 3326 0.00373855463356434 4742 2994751
SGTC_1976 st070609 63.5 µM -2.67752545055036 0.00394968943285445 no 3327 0.00370841087825589 4767 682556
SGTC_3266 9136860 49.47 µM -2.67892756637875 0.00393347058903901 no 3328 0.00369291845568749 4598 4871271 YPR165W RHO1
SGTC_2757 clomiphene 4.22 µM -2.69208584945901 0.00378414608929074 no 3329 0.00355033323336955 4751 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1602 st001878 87.6 µM -2.69974149950654 0.00369962494917649 no 3330 0.00346966856009775 4767 595405 YLR310C CDC25
SGTC_2564 betulinic acid 100 µM -2.70338446442754 0.00366000311425285 no 3331 0.00343186524330328 4725 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1420 4'-methoxyflavone 42 µM -2.75114561399615 0.00317463607283568 no 3332 0.00296936191781286 4783 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1209 2323-2347 50.3 µM -2.76055723882411 0.00308612247946011 no 3333 0.00288514227749362 4778 5412760
SGTC_2492 derrusnin 100 µM -2.76565480868065 0.0030391148155251 no 3334 0.00284043168654515 4789 1715307 Part of coumarin class of compounds.
SGTC_1650 st011916 45.8 µM -2.78701849162029 0.00284904523518045 no 3335 0.00265977217102264 4786 242528
SGTC_2097 5376186 200 µM -2.86905796106204 0.00221477353356289 no 3336 0.00205848173708042 4784 742755
SGTC_2587 piperic acid 92.2 µM -2.91642472292944 0.00190976141646838 no 3337 0.00177034075750834 4766 5370536
SGTC_1628 st004252 77.7 µM -2.91949705936728 0.00189136219488567 no 3338 0.00175298350993183 4784 692968
SGTC_2074 5212007 75.395 µM -2.93030837840673 0.00182789040804653 no 3339 0.00169312885372708 4782 758611
SGTC_131 0141-0277 33.849 µM -2.95958003128941 0.00166564175112366 no 3340 0.00154029337697339 4766 1547771
SGTC_2491 paeonol 100 µM -2.97234965018929 0.00159906166455143 no 3341 0.00147764956986039 4787 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2490 carminic acid 95.39 µM -3.03084366296438 0.00132400315120174 no 3342 0.00121935741711532 4780 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2100 5377183 190 µM -3.06762015073658 0.0011739690341843 no 3343 0.00107885349562616 4799 2844202
SGTC_1718 roemerine 11.9335 µM -3.07400990997185 0.0011495475495608 no 3344 0.00105601208370637 4572 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1707 st032323 6.317 µM -3.12611689974083 0.000967103476271564 yes 3345 0.000885655624621376 4711 3132057 YMR211W DML1
SGTC_616 4092-0450 108 µM -3.1292129864977 0.000957148973641197 yes 3346 0.000876376054404912 4793 787165
SGTC_2258 7960471 200 µM -3.23378176341121 0.000671402645146174 yes 3347 0.000610813830905358 4794 2974708
SGTC_2040 5100729 123 µM -3.39088492910847 0.00038676002514164 yes 3348 0.000348336726686284 4804 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1841 st054148 70 µM -3.42009639135796 0.000348189719827645 yes 3349 0.000312994752009143 4805 675442
SGTC_44 0929-0055 61.211 µM -3.43268436853425 0.000332697484637858 yes 3350 0.000298818696593968 4704 1379590
SGTC_1470 k295-0292 231 µM -3.48016077959937 0.000279852209936992 yes 3351 0.000250556480291066 4809 5045612
SGTC_3143 9086658 49.47 µM -3.54463559641076 0.000220529450055856 yes 3352 0.000196578110972148 4779 25236626
SGTC_2098 5376439 882.5 nM -3.89214865766895 5.71537315962802e-05 yes 3353 4.96801647164026e-05 4810 2844116
SGTC_3142 9086498 49.47 µM -3.9657869340058 4.23181600196446e-05 yes 3354 3.65770946914601e-05 4773 25236367
SGTC_2342 7990637 118.86 µM -4.2826653740887 1.09599166235108e-05 yes 3355 9.23338931599179e-06 4806 2033102 YER133W GLC7
SGTC_2086 5274770 176.623 µM -5.09948639437693 2.18032866542872e-07 yes 3356 1.70288174082529e-07 4809 689278