SGTCid condition conc unit GTT1|YIR038C.score GTT1|YIR038C.strain.pval GTT1|YIR038C.strain.significant GTT1|YIR038C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3224 9130643 49.47 µM 5.47159693220659 6.97949828450547e-08 yes 1 2.22999144105197e-08 6 17644395
SGTC_2291 7917025 104.35 µM 5.44613813437326 7.96687074376695e-08 yes 2 2.57375834576598e-08 25 2964612
SGTC_1337 1486-1011 40.3 µM 5.26866101057879 1.97213107835725e-07 yes 3 6.87112370168908e-08 3 X1337
SGTC_2304 7443016 91.4 µM 5.14633521118907 3.62408917531053e-07 yes 4 1.32812294893316e-07 9 939854
SGTC_2138 5575593 77.673 µM 4.97958750930006 8.13141304870181e-07 yes 5 3.1859968196681e-07 1 762213
SGTC_1527 coumarin 137 µM 4.87802194591522 1.31434935985062e-06 yes 6 5.3577502476247e-07 4 323 A hepatotoxic, DNA x-linker.
SGTC_1293 1000-1278 195 µM 4.7528977488566 2.34528357122363e-06 yes 7 1.00260885736265e-06 2 678847
SGTC_2152 5568786 200 µM 4.47747749585129 7.99229390624533e-06 yes 8 3.77650932770142e-06 6 5399883
SGTC_3325 9138760 55.175 µM 4.23539345280136 2.22242108654093e-05 yes 9 1.14075932916103e-05 20 43844959
SGTC_2287 7945887 168.79 µM 4.12217187898196 3.52302376227122e-05 yes 10 1.87658494867315e-05 6 1245853
SGTC_2696 st077691 74.316 µM 4.07425408943413 4.26711728266578e-05 yes 11 2.30810304729492e-05 30 757133
SGTC_2382 9035899 200 µM 4.03557046216736 4.97373448138507e-05 yes 12 2.72348944896908e-05 14 6462679
SGTC_2251 lansoprazole 556 µM 3.87975844584209 9.09917695116037e-05 yes 13 5.22801251519922e-05 22 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2930 9013230 14.89 µM 3.85458518318372 0.000100120563863604 yes 14 5.7963008168692e-05 43 2995857
SGTC_1241 0364-0022 50.8 µM 3.78833455162552 0.00012842726858755 yes 15 7.58302686668834e-05 37 4563895
SGTC_2427 5545055 42.75 µM 3.74273802969329 0.000152096773590248 yes 16 9.10129850584827e-05 19 5372858
SGTC_2086 5274770 176.623 µM 3.71878349700577 0.000166112036563668 yes 17 0.000100092267972109 29 689278
SGTC_1045 1348-1485 165 µM 3.66610283830081 0.000201293804961519 yes 18 0.000123137460272327 43 6810614
SGTC_1321 1326-2144 215 µM 3.64713933183938 0.000215579544256874 yes 19 0.000132588073580394 15 3513030
SGTC_621 3584-0052 32.1 µM 3.64026191253792 0.000220990381879701 yes 20 0.000136180426179851 32 2273927
SGTC_3191 9110352 49.47 µM 3.62570991511858 0.000232859740091877 yes 21 0.000144084349931773 18 17122424
SGTC_2050 5263056 171 µM 3.46821414247781 0.000405443136579895 yes 22 0.000261964802917746 65 763468 YGL055W OLE1
SGTC_1193 1488-0126 41.5 µM 3.45601230022056 0.000422864638895575 yes 23 0.000274115151559037 43 1384710
SGTC_963 1269-2853 151 µM 3.42602926439156 0.000468665347851172 yes 24 0.000306237194637087 43 3668223
SGTC_2145 5634607 200 µM 3.41997946170724 0.000478446861948573 yes 25 0.000313129318646372 17 308662
SGTC_294 k038-0071 157 µM 3.38927819229177 0.000531065766232441 yes 26 0.000350384384644479 88 24152826
SGTC_1156 4092-0367 4.88 µM 3.27568154569976 0.000775824267255151 yes 27 0.000527036715286164 50 1357585
SGTC_2051 5263410 176 µM 3.2142395557319 0.000947985473787113 yes 28 0.000653952529767057 39 227584
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 3.20831119401581 0.000966330477029783 yes 29 0.000667584714484972 27 61125 An anti-inflammatory.
SGTC_282 k297-0036 65.7 µM 3.1899981003696 0.00102507763905788 no 30 0.000711368644580233 14 5061378
SGTC_2037 5169046 200 µM 3.16862462389555 0.0010977767681777 no 31 0.000765810348088893 31 5718022
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.12822160651621 0.00124825483648479 no 32 0.000879337636920755 51 75037 A free radical scavenger.
SGTC_3303 9125618 40.5795 µM 3.07453446895554 0.00147741191666058 no 33 0.00105415678688507 99 22695467
SGTC_1381 2324-0066 62.1 µM 2.97116569556017 0.00202974886674863 no 34 0.00148335835126 79 10885928
SGTC_1329 1447-1697 50.6 µM 2.94646576441958 0.00218685940630858 no 35 0.00160713999171485 52 2840515
SGTC_3056 9094900 49.47 µM 2.93555442682462 0.00225971080400421 no 36 0.00166476098085892 70 25236784
SGTC_3146 9095609 49.47 µM 2.92844497671683 0.00230835396772073 no 37 0.0017033106115056 69 17173999
SGTC_2938 9059746 27.26 µM 2.9188597674719 0.00237543732772126 no 38 0.00175657112650387 89 6471769
SGTC_1786 berberine 21.6 µM 2.91781333475115 0.00238286674771025 no 39 0.00176247648375168 104 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2162 5663267 200 µM 2.91477848203194 0.00240453255808371 no 40 0.00177970544237673 47 6456493
SGTC_1494 4358-1428 177 µM 2.90031839161251 0.00251023120125411 no 41 0.00186391893872083 61 1564571
SGTC_245 methotrexate 289.6 µM 2.90005366141723 0.00251220485739449 no 42 0.00186549390391104 95 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1690 st023502 41.2 µM 2.86278461671737 0.00280447172821195 no 43 0.00209967957420564 50 24207482
SGTC_1898 st060199 18.6 µM 2.85178714184685 0.00289639373250561 no 44 0.00217371007927052 47 688866
SGTC_2958 9077254 16.72 µM 2.85112382849728 0.00290202391664857 no 45 0.00217825000161825 88 16457351
SGTC_1292 0kpi-0043 232 µM 2.84613172767647 0.00294471428739712 no 46 0.00221269420948657 67 3333905
SGTC_3109 9122853 49.47 µM 2.82566638460407 0.00312570389784488 no 47 0.0023591188332928 47 1234709
SGTC_394 menadione 8.33 µM 2.82331448996937 0.00314713230923537 no 48 0.0023764961630581 83 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2762 leflunomide 42.06 µM 2.81744218155685 0.00320121404945184 no 49 0.0024203914770818 97 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1507 4075-3230 155 µM 2.81182346008389 0.00325374170134106 no 50 0.00246307662498152 44 659771
SGTC_300 r073-0011 5.04 µM 2.81152601618678 0.0032565438956659 no 51 0.00246535515316684 74 2735780
SGTC_2197 6588183 93.1375 µM 2.80956842754929 0.00327504039320825 no 52 0.00248039861448738 59 884136
SGTC_497 capsazepine 133 µM 2.80780283534297 0.00329180377051928 no 53 0.00249403779149846 61 2733484 A calcium channel blocker.
SGTC_1302 1159-0335 255 µM 2.7993788525023 0.00337285218521759 no 54 0.0025600512710971 55 649284
SGTC_2043 5101342 149 µM 2.78733416069038 0.00349185228394208 no 55 0.00265718237277339 75 678451
SGTC_1450 4112-4260 37.6 µM 2.76430168187829 0.00372995890572886 no 56 0.00285223857311081 86 1633175
SGTC_3268 9137683 49.47 µM 2.75453919702426 0.00383520294001253 no 57 0.00293874246403977 47 1953228
SGTC_1699 st031318 29.054 µM 2.71353430046577 0.00430691062927482 no 58 0.00332848381044507 77 5340658
SGTC_2124 5246320 200 µM 2.71260812761342 0.00431813935953875 no 59 0.00333779991775405 90 579342
SGTC_2569 tetrandrine 100 µM 2.70130907235501 0.00445724884605179 no 60 0.0034533561292337 95 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_298 1391-0729 10 µM 2.68370050036968 0.00468202689427511 no 61 0.00364061505685102 71 3237558
SGTC_833 3852-0053 558 µM 2.6604004105403 0.0049949816863623 no 62 0.00390239023130888 84 3123681
SGTC_2106 5357045 167.29 µM 2.65600703403181 0.00505603665350189 no 63 0.00395359825218536 79 668842
SGTC_1934 st074720 32.6 µM 2.63735589977492 0.00532269515231084 no 64 0.004177755846125 146 17250992
SGTC_1 0258-0098 57.368 µM 2.62928545393291 0.00544190578510639 no 65 0.00427822519399188 65 6790032 YDR047W HEM12
SGTC_499 genistein 192 µM 2.62604942556873 0.00549036863828023 no 66 0.00431911365922064 28 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2134 5324836 1.464 µM 2.61069566570264 0.00572557175186752 no 67 0.00451791325398156 79 699272
SGTC_632 0781-2353 4.65 µM 2.60379125943843 0.00583422433082181 no 68 0.00460994456183272 131 6811515 YHR007C ERG11
SGTC_1324 1418-0026 34.4 µM 2.59504641475559 0.00597446258947576 no 69 0.00472890729669651 86 1372513
SGTC_3033 9090887 49.47 µM 2.57039216909594 0.00638605535265695 no 70 0.00507917229332218 124 19325384
SGTC_570 0987-0065 62.6 µM 2.55154034465011 0.0067175114952006 no 71 0.00536239531960504 60 3104428
SGTC_2156 5649887 115 µM 2.55054884867431 0.00673535754309097 no 72 0.00537767253173057 111 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3029 9088683 49.47 µM 2.54734456422302 0.00679331862873054 no 73 0.00542730986545546 108 25236615
SGTC_2893 9048488 25.97 µM 2.54520232713285 0.00683231410015564 no 74 0.00546072183537095 102 6467338
SGTC_2276 7947513 42.08 µM 2.50198271971888 0.00766240979042426 no 75 0.00617499763287102 114 2105100
SGTC_252 miconazole 1.30953 nM 2.5012902353005 0.00767640295079901 no 76 0.00618708613515411 136 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1512 0259-0544 12.2 µM 2.49977409483131 0.00770711844734331 no 77 0.00621362617778812 129 18476
SGTC_2119 5528445 120.635 µM 2.49612187825975 0.00778155326525782 no 78 0.00627797263318408 116 791935
SGTC_857 0438-0306 1.35 µM 2.48672713597589 0.00797593866320056 no 79 0.00644621204903742 88 4686136
SGTC_1549 4'-methoxyflavonol 74.6 µM 2.48661768341009 0.00797822826907343 no 80 0.00644819539024126 86 97141
SGTC_1731 st035964 63 µM 2.47688286735674 0.0081841935815943 no 81 0.00662676949099879 131 6739575
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.46977494636263 0.00833751671416138 no 82 0.00675990392140837 130 1377
SGTC_220 paclitaxel 373.376 µM 2.46805785305206 0.00837493177917449 no 83 0.00679241809819196 71 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.46326769051976 0.00848008859290378 no 84 0.0068838541181673 156 23665772 A membrane-active detergent.
SGTC_2517 totarol 10 µM 2.46103359426261 0.00852952794698249 no 85 0.00692686966878991 112 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_223 busulfan 5 mM 2.45824510096987 0.00859159051139621 no 86 0.00698089250949738 68 2478 A DNA alkylator.
SGTC_1511 0906-3109 28.5 µM 2.42165914038076 0.00944331930521871 no 87 0.00772491731202295 207 2882180
SGTC_541 4513-1321 94 µM 2.41908925908178 0.00950583130873577 no 88 0.0077797108441421 124 747515
SGTC_2424 5537928 59.2 µM 2.41266040914421 0.00966379930957127 no 89 0.00791828354874692 162 5382802
SGTC_619 1652-1634 108 µM 2.41166209435013 0.00968853429951577 no 90 0.00793999564130726 122 5400454
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.39807414509395 0.0100307407032135 no 91 0.00824076433896835 148 521171
SGTC_3353 9151644 39.2805 µM 2.38903800657241 0.0102641099614957 no 92 0.00844627736505448 110 4909158
SGTC_1653 st012112 65 µM 2.38491147551818 0.0103722481948209 no 93 0.0085416157955248 98 720429
SGTC_591 4299-0174 154 µM 2.38332677934988 0.010414039297096 no 94 0.00857847841171125 88 5509088
SGTC_1842 st055362 61.2 µM 2.37816172817686 0.0105512707965062 no 95 0.00869959641979974 130 676032
SGTC_998 3996-0085 177 µM 2.37632010458197 0.0106005809704331 no 96 0.00874314285248634 138 715391
SGTC_3141 9094609 49.47 µM 2.31051664434362 0.0124992655065123 no 97 0.0104297840681694 174 25236309 YDL196W YDL196W
SGTC_2591 skatole 100 µM 2.30691467546767 0.0126112043059251 no 98 0.0105297886190167 152 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2775 cyproheptadine 69.59 µM 2.28840023107611 0.0132003731008117 no 99 0.0110571121030152 128 2913 A selective serotonin reuptake inhibitor.
SGTC_3115 9123671 49.47 µM 2.27745899025835 0.0135596084122277 no 100 0.0113794154459303 93 3286988
SGTC_3122 9126309 49.47 µM 2.26697112867536 0.0139118472262024 no 101 0.0116959947371808 115 17591206
SGTC_2216 7189485 200 µM 2.25264747658257 0.0144056396120269 no 102 0.0121406925474304 91 731273
SGTC_2012 4023501 200 µM 2.24110025584805 0.0148146333668748 no 103 0.0125097908205195 157 3477460
SGTC_2772 vinpocetine 57.06 µM 2.23457843521692 0.0150500145628699 no 104 0.0127225189483953 176 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.23201177265218 0.0151435263373918 no 105 0.012807092430886 173 5377381
SGTC_304 1310-0298 97 µM 2.21848093854587 0.0156447931312439 no 106 0.0132610289253806 239 1550234
SGTC_1470 k295-0292 231 µM 2.21198191622318 0.0158905760302937 no 107 0.0134839572347957 161 5045612
SGTC_1815 st051655 58.2 µM 2.20898678563965 0.0160049571191377 no 108 0.0135877800240883 105 5984156
SGTC_3068 9116768 49.47 µM 2.20142246878967 0.0162969772151344 no 109 0.0138530649049278 172 41904888
SGTC_1637 st007924 17.4 µM 2.19747332658423 0.0164512385842937 no 110 0.0139933297104903 174 683336
SGTC_792 4534-1957 155 µM 2.18819021536311 0.0168187857659702 no 111 0.0143278747722929 185 1717904
SGTC_2777 climbazole 1.536 µM 2.18467674385537 0.0169597156652744 no 112 0.014456278264936 213 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2855 9016525 58.44 µM 2.18446325889375 0.0169683112651957 no 113 0.0144641121206826 179 43811474
SGTC_2052 5265182 7.135 µM 2.17704997282005 0.0172691131528937 no 114 0.0147384195391677 182 1239884
SGTC_3131 9127911 49.47 µM 2.17544695290097 0.0173347530227183 no 115 0.0147983196143003 178 45595681
SGTC_3333 9141820 12.094 µM 2.17511349398322 0.0173484341182816 no 116 0.0148108062525361 144 1939433
SGTC_2323 6148992 148.28 µM 2.1750560715546 0.0173507909664026 no 117 0.0148129573959705 158 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1804 st050076 49.1 µM 2.17495468083955 0.0173549531180952 no 118 0.0148167563234877 167 3895976
SGTC_1161 k007-0610 110 µM 2.16925106525383 0.0175904672627763 no 119 0.0150318140799843 307 5843850
SGTC_2942 9052777 62.25 µM 2.16124843418598 0.0179255078742787 no 120 0.015338076929762 217 6469503
SGTC_3255 9139072 49.47 µM 2.1449081798594 0.0186265403295055 no 121 0.0159800945498875 166 17646060
SGTC_9 0092-0002 10.449 µM 2.14221761388614 0.0187441808540306 no 122 0.0160879873836099 178 759368
SGTC_548 1436-0017 110 µM 2.13301755257205 0.0191512270852839 no 123 0.0164616431700489 226 9677137
SGTC_3196 9111891 49.47 µM 2.12842541288491 0.0193571969835432 no 124 0.0166509139931646 138 18891510
SGTC_2779 methotrexate 400 µM 2.12644150793891 0.0194467610254818 no 125 0.0167332573560706 201 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3066 9117245 49.47 µM 2.12538927297092 0.0194944072275675 no 126 0.0167770723123841 179 17176980
SGTC_555 4296-0685 37 µM 2.12528807497277 0.0194989947916997 no 127 0.0167812913548742 168 2908540 YHR072W ERG7
SGTC_1047 2043-3044 82 µM 2.12304637217021 0.0196008522975216 no 128 0.0168749830957571 217 669592
SGTC_399 oxolinic acid 75 µM 2.12028760599596 0.019726823748189 no 129 0.0169908991189946 150 4628 A DNA gyrase inhibitor.
SGTC_2792 7535235 81.82 µM 2.11943703073003 0.0197658012715339 no 130 0.0170267750401917 191 1281891
SGTC_1075 aripiprazole 15.2 µM 2.11835091080796 0.0198156676205885 no 131 0.0170726799798235 228 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2090 5301565 104.445 µM 2.11626940771502 0.0199115328099414 no 132 0.0171609505265552 230 2056344
SGTC_1405 3909-7894 12 µM 2.11220622159862 0.0200998000564969 no 133 0.0173343825605767 170 7104060
SGTC_2153 5569715 200 µM 2.10679958808079 0.0203526550518065 no 134 0.0175674776137615 147 2054701
SGTC_481 bay k-8644 50 µM 2.10274545592893 0.0205440211254412 no 135 0.0177440131254488 183 2303 A calcium channel antagonist.
SGTC_2789 5281112 71.43 µM 2.10189588720306 0.020584315692823 no 136 0.0177811984546054 236 765948
SGTC_2326 6164455 177.58 µM 2.1009032055943 0.0206314828217342 no 137 0.0178247319894553 179 2888790
SGTC_2002 4023503 131 µM 2.09026532184116 0.0211427128735056 no 138 0.0182969862851852 255 4736863 YCR052W RSC6
SGTC_1218 1348-1416 30.7 µM 2.06743044069793 0.0222763709855271 no 139 0.0193468061737994 197 6787668
SGTC_1733 st037357 54.9 µM 2.06558829680045 0.022370020423269 no 140 0.0194336852113028 237 1272339 YGL099W LSG1
SGTC_815 1582-0027 36.9 µM 2.06424226236166 0.0224386588329671 no 141 0.0194973761468388 194 3128206
SGTC_3074 9116018 49.47 µM 2.06160357790442 0.0225737288639311 no 142 0.0196227465629739 161 17027303
SGTC_215 1287-0124 461.5 µM 2.05402215817347 0.0229656291711774 no 143 0.0199867735751259 111 5560863
SGTC_510 ag-490 170 µM 2.04970938308754 0.0231911123825336 no 144 0.0201963994160434 129 5328779
SGTC_1608 st001473 40.5 µM 2.03352013897692 0.0240542260857834 no 145 0.0210000005185512 234 7292267
SGTC_629 3448-6466 76.7 µM 2.00474181945154 0.0256551446354202 no 146 0.022495327635881 228 573744
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.00242626717679 0.0257877466116655 no 147 0.0226194528854001 94 279621
SGTC_2560 caryophyllene 100 µM 1.99577117114695 0.0261720529802331 no 148 0.0229794180682211 239 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3184 9108758 49.47 µM 1.99562251625434 0.0261806916179704 no 149 0.0229875133871619 167 902885
SGTC_2056 5235370 200 µM 1.9932046027072 0.026321536582455 no 150 0.0231195236602115 243 5511916
SGTC_1414 3917-0015 5.4 µM 1.97933296953652 0.0271418605957058 no 151 0.0238892649643789 181 6618702
SGTC_260 nsc-65238 3.989 µM 1.97679045821251 0.0272945062945841 no 152 0.0240326603517084 193 3246252
SGTC_877 0771-0151 33.1 µM 1.96926292326102 0.0277506435004814 no 153 0.0244614532462511 230 6166523
SGTC_1963 st076565 50.3 µM 1.96291904879076 0.0281399717653511 no 154 0.0248277904991579 192 4914280
SGTC_901 1112-0062 60.1 µM 1.96157535479302 0.0282230162240488 no 155 0.0249059719529523 184 1908457
SGTC_509 pifithrin 175 µM 1.95712387074795 0.0284995904309193 no 156 0.0251664532783716 166 4817 A p53 inhibitor.
SGTC_1209 2323-2347 50.3 µM 1.95270900174864 0.0287761130404933 no 157 0.0254270432189342 201 5412760
SGTC_2679 rapamycin 1 nM 1.94519545840494 0.0292518464862076 no 158 0.0258757291250135 397 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3154 9100113 49.47 µM 1.94440374675864 0.0293023533856894 no 159 0.0259233912012835 241 25237525
SGTC_2440 5628896 157.78 µM 1.94137173162925 0.0294964497077977 no 160 0.0261066022724917 212 5522048
SGTC_1889 st059080 5.18 µM 1.94105972658849 0.0295164833288571 no 161 0.0261255166352644 240 176925 Isolated from Daphnopsis sellowiana.
SGTC_2684 capsaicin 100 µM 1.93417706801927 0.0299612945074159 no 162 0.0265456804426235 221 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1076 itraconazole 331 nM 1.93393070575299 0.0299773188596398 no 163 0.0265608241082624 240 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2971 9092186 9.93 µM 1.93275278347002 0.0300540337290763 no 164 0.0266333297127876 235 25236400
SGTC_460 trequinsin 123 µM 1.92812141332318 0.0303572421386291 no 165 0.0269200130464418 172 5537 A vasodilator.
SGTC_139 0099-0334 718.624 µM 1.92755526895753 0.030394479968899 no 166 0.0269552336160906 298 97690
SGTC_2817 7995342 71.43 µM 1.91549028427517 0.031197087365199 no 167 0.0277150035078746 212 18879975
SGTC_866 0495-0101 262 µM 1.91461449315824 0.0312560243808624 no 168 0.0277708427193823 220 635694
SGTC_324 1315-0088 19.6 µM 1.91404247169242 0.0312945686844134 no 169 0.0278073645891232 182 6787421
SGTC_1989 st071868 50.2 µM 1.90553911529671 0.0318721970572605 no 170 0.0283550139554462 253 16414057
SGTC_1297 1068-0111 14.1 µM 1.89849403786971 0.0323574105803437 no 171 0.0288155162166707 224 767057
SGTC_2621 lithochol-11-enic acid 100 µM 1.89688985020947 0.0324687431107059 no 172 0.0289212386562393 283 6708711
SGTC_2371 9071574 200 µM 1.89476590653141 0.0326166333269886 no 173 0.0290617109324965 208 45596039
SGTC_2832 7992762 51.95 µM 1.89329954942125 0.0327190596098963 no 174 0.0291590225284089 239 2985177
SGTC_1914 st062367 72.6 µM 1.88975768300117 0.0329675562801255 no 175 0.0293951877533569 230 978205
SGTC_2680 butyl paraben 22.24 µM 1.88558886784727 0.0332620301243032 no 176 0.0296751893384609 190 7184 An antifungal and steroid mimetic.
SGTC_423 5-fluorouracil 457 µM 1.88498103655947 0.0333051460980638 no 177 0.0297161990615423 257 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2868 9035608 32.47 µM 1.86800721574952 0.0345278792570819 no 178 0.0308805325780506 275 6462614
SGTC_115 0527-0192 112.043 µM 1.86300115666179 0.0348954601852517 no 179 0.0312310517477541 381 4233931
SGTC_3245 9134821 49.47 µM 1.85800968055261 0.0352651625424689 no 180 0.0315838198031941 271 17014901
SGTC_2154 5570129 200 µM 1.85211773212629 0.035705688183532 no 181 0.0320044593758565 276 673366
SGTC_2332 7982454 138.89 µM 1.85024743153674 0.0358464650900028 no 182 0.0321389477536546 331 2981748
SGTC_3054 9094397 49.47 µM 1.84345029358636 0.0363619176912296 no 183 0.0326316463694493 304 2598354
SGTC_806 3966-4455 5.86 µM 1.83677837378909 0.036873758769401 no 184 0.0331213098765263 240 714982
SGTC_1821 st053465 65.6 µM 1.83508659862025 0.037004476546514 no 185 0.0332464296360659 224 675086
SGTC_1347 1493-0251 600 nM 1.83339804522763 0.0371353228543807 no 186 0.0333716990539036 284 3986378
SGTC_1476 4112-3294 3.34 µM 1.8270111517109 0.0376336682640834 no 187 0.0338490463480125 261 704369
SGTC_2928 9011484 9.79 µM 1.82587081233785 0.0377232165393509 no 188 0.0339348618319506 258 2994751
SGTC_2726 cimetidine 79.27 µM 1.81917182791433 0.0382527907155314 no 189 0.0344426097204696 198 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3203 9113543 49.47 µM 1.81382083517513 0.0386801438074497 no 190 0.0348526568612238 297 17018012
SGTC_1718 roemerine 11.9335 µM 1.81382077164431 0.0386801489042877 no 191 0.0348526617532841 352 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2426 5582046 32.21 µM 1.79069369671705 0.0405721233159051 no 192 0.0366712308898133 307 2251934
SGTC_2719 novobiocin 32.65 µM 1.78848726376035 0.0407564858979417 no 193 0.0368487143307218 181 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2225 6654152 15.4 µM 1.78156210844868 0.0413395490955271 no 194 0.0374103340860948 206 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2222 6885208 172.143 µM 1.78038612413524 0.0414392293374796 no 195 0.0375063955254409 197 609514
SGTC_2541 muurolladie-3-one 83.07 µM 1.77957265457242 0.0415082955536408 no 196 0.0375729623766598 293 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1049 3226-0134 66 µM 1.76802933989744 0.0424984495515025 no 197 0.0385279994182952 337 5702385
SGTC_315 k915-0449 187 µM 1.76721996152569 0.0425685864083558 no 198 0.0385956989716601 362 20970215 YNL149C PGA2
SGTC_1565 sinapyl alcohol 95.1 µM 1.76175309107884 0.043044773756828 no 199 0.0390555117252212 302 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1342 1486-1464 234 µM 1.75902464355264 0.0432840378002095 no 200 0.0392866614570979 291 3253938
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.75584721800637 0.043564026138754 no 201 0.0395572497337434 266 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2623 humulene 100 µM 1.75325519037577 0.0437935114045821 no 202 0.039779106683109 245 6187145 An anti-inflammatory.
SGTC_2963 9082507 9 µM 1.73819898016795 0.0451458648230105 no 203 0.0410878793765543 299 16459611
SGTC_781 4335-2806 94.4 µM 1.73642286439721 0.0453075884023096 no 204 0.0412445461706465 338 845254
SGTC_3279 9140807 49.47 µM 1.71727197217913 0.0470811287160514 no 205 0.0429647452990903 281 45595718
SGTC_1658 st012944 20 µM 1.71702040071538 0.0471047916021333 no 206 0.0429877222839899 341 24207260
SGTC_638 3970-0837 4.09 µM 1.71635839367215 0.0471671057397916 no 207 0.0430482333619062 330 4118451 YLR208W SEC13
SGTC_3350 9150499 3.57 µM 1.71620869783438 0.0471812056333593 no 208 0.04306192591823 376 4910996 YPR165W RHO1
SGTC_2365 9042475 200 µM 1.71209847903406 0.0475696700063397 no 209 0.0434392608140645 340 6464479
SGTC_1642 st009582 77.7 µM 1.70987726416933 0.0477806650741705 no 210 0.0436442857634814 279 6739311
SGTC_2652 actinonin 100 µM 1.7078907932971 0.0479699957512308 no 211 0.0438283039114458 243 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2887 9044784 58.44 µM 1.70633442347091 0.0481187526218398 no 212 0.0439729161994128 333 6465546
SGTC_664 1222-0054 14.9 µM 1.69846127843887 0.0488769283193391 no 213 0.0447103674847596 336 6813991
SGTC_1902 st060212 70.5 µM 1.69201463027522 0.0495048162536542 no 214 0.0453215920695206 328 688944
SGTC_2622 2-methoxyxanthone 59.94 µM 1.68944620812646 0.0497567608412321 no 215 0.045566976072322 319 71034 A hepatoprotective.
SGTC_1236 0330-0013 258 µM 1.68416096170234 0.0502784250943232 no 216 0.0460752827551711 289 4617066
SGTC_543 3844-1095 191 µM 1.68161489018665 0.0505312784298596 no 217 0.0463217706648103 373 4230703
SGTC_595 3909-8003 73.7 µM 1.67844849139116 0.0508471493474187 no 218 0.0466297889601214 327 699517
SGTC_3222 9128301 49.47 µM 1.67742743281302 0.0509493417842114 no 219 0.0467294643528296 322 4911358
SGTC_1455 4262-0120 131 µM 1.67369784096376 0.0513240071344779 no 220 0.0470949991657998 343 1529587
SGTC_2643 anethole 100 µM 1.67051676829305 0.0516452986220174 no 221 0.0474085823112504 364 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3120 9124077 49.47 µM 1.66626222590924 0.0520775087393168 no 222 0.0478305984438809 302 18774327 YGL155W CDC43
SGTC_1839 st053978 48 µM 1.66568172365411 0.0521367028830988 no 223 0.0478884120337729 330 3788398
SGTC_350 k064-0020 19.8 µM 1.66554071968778 0.0521510892016541 no 224 0.0479024633927761 378 2790705
SGTC_835 0312-0010 67.2 µM 1.66514532527689 0.0521914472246054 no 225 0.0479418829300146 300 1626196
SGTC_567 1080-0542 68.4 µM 1.65512103796273 0.0532229396615089 no 226 0.0489499740966149 307 5950415
SGTC_927 2425-1185 123 µM 1.65396706002267 0.0533427133577257 no 227 0.0490671028620604 336 730375
SGTC_1350 1495-0454 146 µM 1.65269486613903 0.0534750043921962 no 228 0.0491964898866626 403 1069057
SGTC_824 1304-0008 100 µM 1.65157641750719 0.0535915226059297 no 229 0.0493104653648227 390 768245
SGTC_2301 7769476 200 µM 1.65119002587979 0.0536318229881146 no 230 0.0493498895568594 307 977820
SGTC_2722 naftopidil 47.16 µM 1.64611956598044 0.0541628959009116 no 231 0.0498695724431872 336 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3123 9126162 49.47 µM 1.63860036672007 0.0549580982268889 no 232 0.0506482579619541 333 25239884
SGTC_1713 st033146 12.748 µM 1.63609707248799 0.0552248748220906 no 233 0.0509096364041374 366 674619
SGTC_2383 9036125 200 µM 1.63408933289625 0.0554395783524452 no 234 0.0511200471691688 283 79580
SGTC_1266 0828-0227 32.9 µM 1.63389683729856 0.0554601980101443 no 235 0.0511402569776032 338 3913820
SGTC_1776 st049249 45.9 µM 1.63300183896335 0.0555561475754108 no 236 0.0512343049512966 385 1822314
SGTC_181 1447-1644 8.07 µM 1.62723671195953 0.05617735032126 no 237 0.0518434167317454 355 534600
SGTC_2418 pentamidine 31.67 µM 1.62625291595171 0.0562839010639866 no 238 0.0519479317477342 362 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1312 1218-2183 165 µM 1.62621600627747 0.0562879016917495 no 239 0.0519518561572445 359 6744073
SGTC_948 3448-0295 75.3 µM 1.62276006822452 0.0566634838945271 no 240 0.0523203525033906 408 678569
SGTC_2062 5245942 200 µM 1.62103340541498 0.0568518712264261 no 241 0.0525052373110084 385 1376160
SGTC_1316 1272-0050 65.9 µM 1.62082967852492 0.0568741313183467 no 242 0.0525270858108144 330 7340392
SGTC_1822 st052468 42 µM 1.61187062107399 0.0578598423387963 no 243 0.0534950482283745 319 2873678
SGTC_3299 9121982 43.1275 µM 1.60749050090681 0.0583466238383502 no 244 0.0539734057580316 376 17594604 YPL160W CDC60
SGTC_2334 9017922 200 µM 1.60698853439314 0.0584026143549032 no 245 0.0540284416449292 341 3163164
SGTC_1833 st055984 71 µM 1.60625515542099 0.0584844930069904 no 246 0.0541089295728493 338 676288
SGTC_2420 aureobasidin a 50 nM 1.60556394077459 0.0585617466786975 no 247 0.0541848768339846 427 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_508 roscovitine 141 µM 1.60358207791566 0.058783694003752 no 248 0.0544031019064218 312 160355 A CDKinase inhibitor.
SGTC_2163 5671233 125 µM 1.60344577034554 0.0587989832162918 no 249 0.0544181363963897 394 701023
SGTC_1752 st044819 83.042 µM 1.59717529239984 0.0595057038490157 no 250 0.055113319301554 374 441209 YML126C ERG13
SGTC_2877 9040724 71.43 µM 1.59474194812902 0.0597817428955982 no 251 0.0553849767041179 338 6463895
SGTC_587 k089-0003 57 µM 1.59069167687815 0.0602434298007022 no 252 0.0558394904822916 229 9659696
SGTC_936 3005-4620 401 µM 1.58896120534596 0.0604415337169801 no 253 0.0560345757656045 400 777207
SGTC_1680 diphenhydramine 100 µM 1.5877414446062 0.060581477622388 no 254 0.0561724085990401 387 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_828 2074-0507 139 µM 1.58228325713025 0.0612108060503768 no 255 0.0567924605815711 407 X828
SGTC_174 3553-0389 74.3 µM 1.57958570781812 0.0615237137215971 no 256 0.057100887209487 337 738071
SGTC_1097 itavastatin 7.23 µM 1.57680903316606 0.0618471030170603 no 257 0.0574197362609684 391 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1583 clindamycin 39.6 µM 1.57448195030047 0.0621191506089225 no 258 0.0576880355792864 362 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_5 0352-0601 109.883 µM 1.57275099371276 0.0623221128650853 no 259 0.0578882435592726 320 762456
SGTC_1568 digitonin 820 nM 1.56442230725399 0.0633059269936243 no 260 0.0588592126958642 432 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_35 0133-0054 64.071 µM 1.56131538076893 0.0636760094029668 no 261 0.0592246781592325 380 99677
SGTC_351 caspofungin 25 nM 1.56064728171163 0.0637558096650538 no 262 0.0593034981446838 532 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_488 nitrendipine 139 µM 1.55724007075066 0.0641639903819022 no 263 0.0597067489852267 399 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_60 0986-0278 202 µM 1.55608961309527 0.0643022719619115 no 264 0.059843392292448 287 3110598
SGTC_1103 duloxetine 36.1 µM 1.55469410112113 0.0644703190669431 no 265 0.0600094700837435 455 60835 A selective serotonin reuptake inhibitor.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.55423167978219 0.0645260788965666 no 266 0.060064581699436 439 23847180
SGTC_1184 1269-1718 139 µM 1.55373805513255 0.0645856426270774 no 267 0.0601234558666257 392 5403821
SGTC_100 0086-0128 49.5915 µM 1.55150547101319 0.0648555732575666 no 268 0.0603902986294542 462 93297
SGTC_2353 9059630 146.67 µM 1.55105353737805 0.0649103207488552 no 269 0.060444427233569 347 4779114
SGTC_1093 fluphenazine 7.97 µM 1.55028240023039 0.0650038195590943 no 270 0.0605368748492773 446 6602611 An atypical antipsychotic.
SGTC_2223 6903751 107.57 µM 1.54578890423543 0.0655507275741311 no 271 0.0610777788131403 334 5598863
SGTC_1864 st057645 30.4 µM 1.54467317257861 0.0656870758443905 no 272 0.0612126685554228 336 688666
SGTC_3092 9117248 49.47 µM 1.54385359216439 0.0657873728743227 no 273 0.061311902419503 353 17141857
SGTC_1854 st056233 32.9 µM 1.53436111909964 0.0669576907687725 no 274 0.0624704186278142 366 5393174
SGTC_1943 st076331 65.2 µM 1.52845977702361 0.067693339268857 no 275 0.0631992114616913 396 24208415
SGTC_2661 dactinomycin 12.96 µM 1.52624738376545 0.0679707350159853 no 276 0.0634741334530572 438 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_162 k030-0015 37.8 µM 1.52614850435037 0.0679831532399643 no 277 0.0634864423516463 395 1809920 YMR134W ERG29
SGTC_1314 1222-0010 41.1 µM 1.52607409484952 0.0679924994528546 no 278 0.0634957063639695 371 3526027
SGTC_641 4092-0595 30 µM 1.52357572869114 0.0683068832004134 no 279 0.0638073650288782 422 786260
SGTC_2610 ononetin 44.17 µM 1.51613625730824 0.0692496795081278 no 280 0.0647424509717158 468 259632
SGTC_1711 st032263 62.8 µM 1.51403433656886 0.0695178618589977 no 281 0.0650085655124236 390 3958979
SGTC_3340 9146634 11.102 µM 1.51115620168435 0.069886377150291 no 282 0.0653743291921444 410 4907387
SGTC_3249 9135183 49.47 µM 1.50952736093011 0.0700955984107731 no 283 0.0655820342967301 422 4902779
SGTC_1318 1280-3875 124 µM 1.50777785784225 0.0703208548430499 no 284 0.0658056954858951 446 373245
SGTC_799 1310-0557 151 µM 1.50747563225466 0.0703598240761512 no 285 0.0658443926372044 436 5354492
SGTC_2484 5809818 12.04 µM 1.50564847795575 0.0705957726988192 no 286 0.0660787183395828 407 2870548
SGTC_2872 9044037 25.97 µM 1.50211982780349 0.0710531638253515 no 287 0.0665330825183616 329 6465195
SGTC_1518 st038567 90.8 µM 1.50166812139459 0.0711118789113316 no 288 0.0665914203708192 356 77966
SGTC_2281 7943571 200 µM 1.49920584795672 0.071432592974018 no 289 0.0669101192084811 425 1244024
SGTC_2844 9010103 25.97 µM 1.49897815477481 0.0714623062660144 no 290 0.0669396496629152 465 2480525
SGTC_1725 st036284 20.55 µM 1.49659560119874 0.0717737916687676 no 291 0.0672492577051382 479 707914
SGTC_94 0334-0113 514.748 µM 1.4947771717432 0.0720122256614502 no 292 0.067486302996321 422 6795178
SGTC_684 1140-0066 328 µM 1.48891357248174 0.0727852029073715 no 293 0.0682550645266987 466 6813534
SGTC_2317 5986382 200 µM 1.4870050931407 0.0730381564688905 no 294 0.068506732892076 406 877883
SGTC_2926 9010726 65.15 µM 1.4866312406835 0.0730877863118158 no 295 0.0685561160070317 441 2994293
SGTC_2565 isoliquiritigenin 100 µM 1.48621825787429 0.0731426408020789 no 296 0.0686106998638114 350 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2419 paclitaxel 166.5 µM 1.47984705277551 0.0739928937500851 no 297 0.0694570342026749 509 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2386 9075165 157.42 µM 1.4764377779091 0.0744509608185578 no 298 0.069913203697278 399 16452277
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.47393905267334 0.0747880597757994 no 299 0.0702490008674847 346 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2723 salbutamol 83.58 µM 1.47369838947473 0.0748205886408587 no 300 0.070281408342232 325 9884233 β2-adrenoceptor agonist
SGTC_2937 9044753 11.33 µM 1.47358385075359 0.0748360738787514 no 301 0.0702968360536287 479 6465530 YGL099W LSG1
SGTC_2219 9098279 200 µM 1.47191184231675 0.0750624020745595 no 302 0.0705223426324331 426 902349
SGTC_3337 9144342 33.5465 µM 1.47172028417648 0.075088365265322 no 303 0.07054821386329 421 17682949
SGTC_3124 9127567 49.47 µM 1.46931473505761 0.0754149891043246 no 304 0.0708737209894447 403 17592030
SGTC_3137 9097352 49.47 µM 1.46791329780157 0.075605773861883 no 305 0.0710638877923963 478 44120435
SGTC_912 3474-0017 2.18 µM 1.46486284760736 0.0760223181660777 no 306 0.071479170448016 445 3360550
SGTC_107 0358-0022 2.6945 µM 1.46140714255747 0.0764963089862396 no 307 0.0719518708600303 303 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1411 3909-8223 150 µM 1.45892133357926 0.076838654927175 no 308 0.0722933803225444 448 X1411
SGTC_2766 oltipraz 83.91 µM 1.45689539429961 0.0771185280480414 no 309 0.0725726287968132 430 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_112 phenothiazine 287.218 µM 1.45122036036263 0.0779066288162496 no 310 0.0733592545734655 444 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_700 3453-2283 142 µM 1.4471760624845 0.0784719859041143 no 311 0.0739238095255313 517 565664
SGTC_1235 benzylparaben 21.5 µM 1.43912030164797 0.0796073700415809 no 312 0.0750582204693269 446 7180
SGTC_1706 st031321 9.9705 µM 1.43432038222724 0.0802897580332122 no 313 0.0757404282173293 436 6103185
SGTC_1905 st060207 84.5 µM 1.42928957562376 0.0810097053124078 no 314 0.0764605104619128 446 1948547
SGTC_2558 carylophyllene oxide 100 µM 1.42613369713265 0.0814638164478617 no 315 0.0769148768158717 479 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1663 st014140 55.4 µM 1.4259607063034 0.0814887641337463 no 316 0.0769398423125893 521 4207120
SGTC_908 3448-7491 47.7 µM 1.42551148044608 0.0815535756637018 no 317 0.0770047019529341 578 1203031
SGTC_972 1319-0219 195 µM 1.42485456179125 0.0816484217962026 no 318 0.0770996232751501 482 23903702
SGTC_1030 k029-0042 36.7 µM 1.42471042435827 0.0816692435273763 no 319 0.0771204622730753 504 6080581
SGTC_1995 st072814 61.1 µM 1.41863071189038 0.0825511534632807 no 320 0.0780033535993438 432 5769371
SGTC_1077 5-fluorocytosine 377 nM 1.41627078348759 0.0828954042878292 no 321 0.0783481192627265 440 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_785 1270-0111 65.3 µM 1.41595935738869 0.0829409136228901 no 322 0.0783937021602498 476 6741994
SGTC_2677 mitomycin C 100 µM 1.41538482081549 0.0830249211473441 no 323 0.0784778488434777 395 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_881 0833-0569 170 µM 1.41411554104407 0.0832107393980609 no 324 0.0786639903935683 481 5418700
SGTC_2870 9038528 12.99 µM 1.41136364484989 0.0836146812954298 no 325 0.0790687084551658 425 6463316
SGTC_1900 st060200 72.8 µM 1.40938970419879 0.0839053358421678 no 326 0.0793599833856975 470 688945
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.4089448163212 0.0839709483820158 no 327 0.0794257431115079 459 5282362
SGTC_3085 9117376 49.47 µM 1.40657292945432 0.084321407174881 no 328 0.0797770324600082 461 16480349
SGTC_213 1246-0773 967 nM 1.40497183046312 0.0845585978008213 no 329 0.0800148274987484 497 6251622
SGTC_1816 st051957 91.6 µM 1.39958780199934 0.085359872117715 no 330 0.0808183944052684 459 674121
SGTC_854 0422-0053 192 µM 1.3957084522214 0.0859407297321994 no 331 0.081401154008304 473 3596728
SGTC_2286 7945697 125 µM 1.39401415184001 0.086195344486353 no 332 0.0816566655889947 484 1245733
SGTC_228 caffeine 993.056 µM 1.39256398025261 0.0864137200401973 no 333 0.0818758408093906 428 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1362 1611-0397 101 µM 1.39164152980168 0.0865528432735874 no 334 0.0820154881323432 490 27816
SGTC_2587 piperic acid 92.2 µM 1.39137873060595 0.0865925090654224 no 335 0.0820553054316761 442 5370536
SGTC_1394 3474-0001 65.7 µM 1.3897873911325 0.0868329893698331 no 336 0.0822967240223076 437 5017666 YIL048W NEO1
SGTC_1036 k216-0215 33.5 µM 1.38965550325505 0.086852942393826 no 337 0.0823167564183542 549 622330
SGTC_71 0417-1750 47.813 µM 1.38854121041684 0.0870216580355595 no 338 0.0824861524996787 520 6811472
SGTC_1811 st050069 61.5 µM 1.3880014434129 0.0871034723874013 no 339 0.0825683027927302 418 3877702
SGTC_153 4077-0274 519.67 µM 1.38727710909344 0.0872133524940105 no 340 0.0826786402165088 442 3121976
SGTC_2272 7805186 180 µM 1.38025105578169 0.0882845671809465 no 341 0.0837546795023866 469 2956062 YPR165W RHO1
SGTC_3171 9103192 49.47 µM 1.37808590838405 0.0886166410207082 no 342 0.0840883828815936 445 13018434
SGTC_557 1315-0110 16.2 µM 1.37794207649187 0.0886387337735051 no 343 0.0841105862806568 498 6833801
SGTC_1174 0739-0097 51.1 µM 1.37589449067096 0.0889536904780924 no 344 0.0844271505783737 512 728447
SGTC_931 2812-0076 566 µM 1.36829611778135 0.0901297444207706 no 345 0.0856097027486844 518 3450959
SGTC_1852 st056254 31.4 µM 1.36787218095742 0.0901956987261736 no 346 0.0856760444578829 488 442583
SGTC_715 0868-0130 184 µM 1.36763234059382 0.0902330279548265 no 347 0.0857135940267216 454 2876258
SGTC_1234 0326-0494 15.5 µM 1.36704471600414 0.0903245355065156 no 348 0.0858056449966783 484 1547813
SGTC_3324 9138759 60.749 µM 1.36537624079364 0.0905847336199952 no 349 0.0860674137445745 497 45595710
SGTC_1979 st071809 45.3 µM 1.36512108501387 0.0906245740745892 no 350 0.0861074980059577 485 4976333
SGTC_1387 3342-1166 1.8 µM 1.3627444440363 0.0909962917719418 no 351 0.0864815327875507 412 3418228
SGTC_2818 7996756 12.99 µM 1.36271730146588 0.0910005435183991 no 352 0.0864858114785032 392 2241621
SGTC_1274 0865-0114 173 µM 1.36093652288932 0.0912798155736966 no 353 0.0867668751578528 498 870624
SGTC_111 0083-0039 52.457 µM 1.36063764872976 0.0913267489652229 no 354 0.0868141138514937 336 759313
SGTC_2987 9018338 71.43 µM 1.3606228098279 0.0913290796427653 no 355 0.0868164597216288 508 5055682
SGTC_1955 wogonin 32.4 µM 1.3605363617847 0.0913426585129972 no 356 0.0868301271654202 473 5281703 A flavanone.
SGTC_1945 st075991 56.6 µM 1.35872585251226 0.0916273891887936 no 357 0.0871167383843707 488 1084980
SGTC_400 oxethazaine 37.5 µM 1.35583026349977 0.0920841316452681 no 358 0.0875765899368989 486 4621 A local anesthetic.
SGTC_222 nsc-310342 10.666 µM 1.35566678978691 0.0921099677306519 no 359 0.0876026052839167 366 432556
SGTC_2117 5521686 200 µM 1.35071042503715 0.0928958428830659 no 360 0.088394105736825 490 803312
SGTC_1514 1189-1591 158 µM 1.34997593310831 0.0930127235189212 no 361 0.0885118514282762 566 767698 YMR146C TIF34
SGTC_2950 9072895 21.46 µM 1.34856219917672 0.0932379987130434 no 362 0.0887388145829865 540 17332245
SGTC_1409 3909-8004 61.9 µM 1.34437661657808 0.0939073249037704 no 363 0.0894133156863322 528 2119279
SGTC_850 0388-0143 75.9 µM 1.34172029492462 0.0943339388985541 no 364 0.0898433520335763 493 67273
SGTC_1034 k072-0165 12.7 µM 1.33889249656934 0.0947896614862065 no 365 0.0903028363624331 547 5835461
SGTC_3175 9106517 49.47 µM 1.33665566295319 0.0951512929579839 no 366 0.0906675302975107 484 41468073
SGTC_1305 1181-0477 144 µM 1.33629360885772 0.0952099220716584 no 367 0.0907266623357995 494 6252086
SGTC_2556 citropten 84.59 µM 1.33066082587692 0.0961254938809109 no 368 0.0916503192176269 575 2775 A potential DNA crosslinker.
SGTC_379 3970-0972 5.9 µM 1.33027707207946 0.0961881052461473 no 369 0.0917134992845067 516 2898042 YBL034C STU1
SGTC_1623 st003709 20.3 µM 1.32823902929704 0.0965211246333356 no 370 0.0920495773002702 601 16192618
SGTC_3147 9097027 49.47 µM 1.32771504937922 0.0966068804992323 no 371 0.0921361299871889 554 25236841
SGTC_1848 st056003 16.4 µM 1.32703896401343 0.0967176130032059 no 372 0.0922478969451622 553 146492
SGTC_2217 6934799 96.0675 µM 1.32586858362186 0.0969095238272435 no 373 0.0924416153918295 519 675606
SGTC_2552 juarezic acid 87.02 µM 1.32259355797298 0.0974480252029839 no 374 0.0929852888570642 617 1549512
SGTC_3221 9128209 49.47 µM 1.32141065719449 0.0976430641313429 no 375 0.0931822372464945 483 16460723
SGTC_593 1203-0218 61.7 µM 1.31948468646724 0.0979612340101287 no 376 0.0935035631706967 546 3666956
SGTC_957 1187-1561 14.1 µM 1.31764910942308 0.0982651773754646 no 377 0.093810568901599 552 1538454
SGTC_309 k408-0051 1.48 µM 1.31713257981412 0.0983508311487689 no 378 0.0938970940209844 625 3640463
SGTC_1656 st012921 11 µM 1.31503779765535 0.0986987599447662 no 379 0.094248599863965 485 6732821
SGTC_248 streptozotocin 5.23457 mM 1.31257815487787 0.0991084384164376 no 380 0.0946625673176915 551 5300 DNA alkylating agent.
SGTC_1451 4152-0210 104 µM 1.31193181267857 0.0992162993290778 no 381 0.0947715712537219 553 659563
SGTC_678 1218-2179 85.9 µM 1.31125441540437 0.0993294347764543 no 382 0.0948859117891534 477 6820081 YOR116C RPO31
SGTC_2017 5132927 60.65 µM 1.30381907065724 0.100577452323444 no 383 0.0961476393744072 550 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_644 1498-1197 63.3 µM 1.30269773738177 0.100766655652657 no 384 0.0963389874108822 581 6741615
SGTC_1433 4060-0023 7.6 µM 1.30135035922352 0.100994342845918 no 385 0.0965692784937197 564 3840627
SGTC_1048 3161-0300 24.5 µM 1.29617206221848 0.10187288959253 no 386 0.0974581062000503 575 2165101
SGTC_3189 9110682 49.47 µM 1.29163625515622 0.102646990748028 no 387 0.0982415711836529 544 17122418
SGTC_1282 0886-0010 32.4 µM 1.29122878149712 0.102716740761025 no 388 0.0983121788542343 627 2836211 YNL267W PIK1
SGTC_930 2810-3379 265 µM 1.2908145995488 0.102787674371978 no 389 0.0983839870297604 626 1015764
SGTC_1880 MG-132 525 µM 1.28730183387728 0.103390709089256 no 390 0.0989945523062035 510 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1391 3442-0225 151 µM 1.2858146173631 0.103646791148452 no 391 0.0992538837718946 497 5227075
SGTC_2649 anisomycin 9.56 µM 1.28513981029602 0.103763137045287 no 392 0.0993717160768214 507 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1121 fusaric acid 630.51 nM 1.28295718228306 0.104140100486892 no 393 0.0997535387389068 568 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_804 1595-0054 20.9 µM 1.28184353216306 0.104332821971558 no 394 0.0999487699311899 532 761523 Stimulates phospholipase C.
SGTC_2783 7738165 71.43 µM 1.27975557836859 0.10469484681897 no 395 0.100315555594005 452 17201110
SGTC_665 3914-0008 307 µM 1.27694117705513 0.105184266954582 no 396 0.100811507634438 555 1069549
SGTC_2511 berberine 10.47 µM 1.27669059656227 0.105227922655687 no 397 0.100855751302286 544 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3121 9125696 49.47 µM 1.27630890845566 0.105294444890799 no 398 0.100923171150726 516 1235365
SGTC_2071 5230951 39.92 µM 1.27615036378045 0.10532208567656 no 399 0.100951185499679 596 1799272
SGTC_983 1491-0821 12.2 µM 1.27545680214299 0.105443063390684 no 400 0.101073802319021 532 46495113
SGTC_2639 lactacystin 53 µM 1.27501649346847 0.105519918419661 no 401 0.101151702107053 606 3870 A proteasome inhibitor.
SGTC_779 1360-0071 233 µM 1.27446081767936 0.10561696837013 no 402 0.101250075184742 608 7566
SGTC_3023 9089636 49.47 µM 1.27441306504586 0.105625311479031 no 403 0.101258532239074 581 17249241
SGTC_929 2805-0021 398 µM 1.27361063421911 0.105765579598671 no 404 0.101400720795809 542 3098024
SGTC_1105 epirubicin 18.1 µM 1.27119701431829 0.106188301554984 no 405 0.10182928424683 549 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_382 3229-0966 23.2 µM 1.2702911645932 0.106347266844368 no 406 0.101990467130433 599 5722370
SGTC_531 3788-1495 174 µM 1.2635890577495 0.107528744258134 no 407 0.103188781536791 565 2896655
SGTC_343 4130-2827 29.8 µM 1.2616010095353 0.107881018577092 no 408 0.103546196366326 597 1118244
SGTC_690 glyoxal 20.3 µM 1.25699803700239 0.10869983547651 no 409 0.104377173199241 592 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_939 1165-0479 45.3 µM 1.2568687130749 0.10872290511919 no 410 0.10440058970236 581 1377347
SGTC_829 1635-0120 117 µM 1.25362639597986 0.109302441853337 no 411 0.104988916171441 612 285054
SGTC_4 0960-0234 25.671 µM 1.25231818914829 0.109536900000099 no 412 0.105226971798167 529 6821112
SGTC_711 k292-0785 179 µM 1.25169301806603 0.109649071234951 no 413 0.105340872587923 575 4146315
SGTC_209 4077-0173 175.592 µM 1.24798255386145 0.110316518247747 no 414 0.10601872312302 464 15993494
SGTC_2158 5657123 3.6195 µM 1.2465702210464 0.110571335996658 no 415 0.10627756320182 576 2858827
SGTC_1195 1502-0147 41.1 µM 1.24387114871038 0.111059484540769 no 416 0.106773494681114 617 817940
SGTC_1965 Pectolinarigenin 58.4 µM 1.24152611410725 0.111484853944276 no 417 0.107205728670697 586 5320438 An anti-inflammatory.
SGTC_360 0957-0399 1.01 µM 1.2376221918299 0.112195576162028 no 418 0.107928090965238 620 6752301 YPR165W RHO1
SGTC_2178 5812956 200 µM 1.23671486015828 0.112361221724813 no 419 0.108096479929581 555 5403383
SGTC_165 k038-0023 64.381 µM 1.23664588344936 0.112373821491187 no 420 0.108109288841746 617 46368543
SGTC_1152 3909-8331 15.9 µM 1.229536309541 0.11367792485359 no 421 0.1094353964625 562 16001939
SGTC_2442 5158906 48.48 µM 1.22870475274049 0.113831158489142 no 422 0.109591261805513 613 1893835
SGTC_2640 pentamidine 10.38 µM 1.22791055147891 0.113977645877359 no 423 0.109740274059374 659 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1410 3909-8106 77.9 µM 1.22443643333775 0.11462001238164 no 424 0.110393816161592 583 1039210
SGTC_1722 st034304 3.6505 µM 1.22305108972424 0.11487688042427 no 425 0.110655200162493 612 4036148 YLR033W RSC58
SGTC_3112 9123419 49.47 µM 1.22088570263805 0.115279202578133 no 426 0.111064649263325 627 17015854
SGTC_3264 9137442 49.47 µM 1.2197018153091 0.115499588151978 no 427 0.111288966596618 574 17015726
SGTC_2231 micatex 6.853 µM 1.2171390107952 0.115977689980514 no 428 0.111775665127841 572 20737 An antifungal of unknown mechanism.
SGTC_2104 5389443 200 µM 1.21659018051644 0.116080258949697 no 429 0.111880090324988 661 2244536
SGTC_275 trichlorophene 5.69 µM 1.21657351369895 0.116083374759884 no 430 0.111883262589017 756 62616
SGTC_1126 isoteolin 1.0172 µM 1.21442967146397 0.116484654499418 no 431 0.112291845326078 598 133323
SGTC_2408 sulbentine 18.36 µM 1.21356891565008 0.116646045411828 no 432 0.112456191528909 605 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_762 1165-0429 115 µM 1.21299639172975 0.116753480881464 no 433 0.112565600029748 612 5967793
SGTC_2455 5377712 9.75 µM 1.20892010289042 0.117520434234741 no 434 0.113346771053709 543 2243908
SGTC_371 0195-0006 7.36 µM 1.20876952708855 0.117548833210766 no 435 0.113375700940279 530 3928593
SGTC_2356 9061756 188.97 µM 1.20781626405096 0.117728733764772 no 436 0.11355897204426 572 20104043
SGTC_1006 4099-6547 255 µM 1.20684982520388 0.11791131969216 no 437 0.113744991816119 617 3146833
SGTC_2376 9072922 81.32 µM 1.2055537937974 0.118156488743542 no 438 0.113994792217879 632 17087968
SGTC_1064 honokiol 6.76 µM 1.20551961193837 0.118162959769633 no 439 0.114001385802582 627 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1755 st041960 45.185 µM 1.20528485863756 0.118207408088834 no 440 0.114046676396555 606 2257073
SGTC_657 3534-0529 86.7 µM 1.20518892222953 0.11822557614379 no 441 0.114065188949536 601 1049549
SGTC_723 4182-0001 115 µM 1.20285380306528 0.118668400747941 no 442 0.114516450023889 581 744821 YLR208W SEC13
SGTC_1648 st011736 69.8 µM 1.20039264530024 0.119136394009894 no 443 0.114993441941622 610 2855514
SGTC_1055 3448-0672 86 µM 1.19818542551551 0.119557207421767 no 444 0.115422419002832 607 748378
SGTC_2729 fluphenazine 10.66 µM 1.19391110517167 0.120375098878016 no 445 0.116256371508296 629 3372 An atypical antipsychotic.
SGTC_688 0527-0193 473 µM 1.19271906610176 0.120603896807592 no 446 0.116489708020252 591 4007154
SGTC_2095 5432005 200 µM 1.19098175655466 0.120937901052238 no 447 0.116830373424527 578 783734
SGTC_3019 9081971 49.47 µM 1.18873627963823 0.12137056594294 no 448 0.117271729741949 660 16451803
SGTC_2227 7312221 64.1025 µM 1.1881535218799 0.121483031028999 no 449 0.117386465579661 597 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2990 9074105 71.4286 µM 1.18725750170265 0.121656094791693 no 450 0.117563032899846 584 6502001
SGTC_1348 1493-0373 93.8 µM 1.18640082650166 0.121821721130077 no 451 0.117732022740446 623 3010129
SGTC_1578 josamycin 24.2 µM 1.18598934061196 0.121901332548505 no 452 0.117813254541669 573 5282165 A P450 substrate.
SGTC_2712 st079126 47.7 µM 1.18058033839494 0.122951227161472 no 453 0.118884739064765 589 3152970
SGTC_523 1934-0222 13.7 µM 1.18018045195892 0.123029096565748 no 454 0.118964226036255 642 1361595
SGTC_883 0850-0245 24.6 µM 1.18005855992355 0.123052839328811 no 455 0.118988462448483 666 6823229 YPR165W RHO1
SGTC_639 0833-0042 114 µM 1.18002452660171 0.123059469089371 no 456 0.118995230089256 676 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2208 7283366 200 µM 1.17918377922316 0.123223327893713 no 457 0.119162501838716 658 898663
SGTC_1145 3546-0597 10.2 µM 1.17810548923018 0.123433706661004 no 458 0.119377276979545 663 875334
SGTC_1080 nisoldipine 24.4 µM 1.17708856775241 0.123632342596911 no 459 0.119580078807673 658 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3005 9076496 71.4286 µM 1.1764483521087 0.123757511097034 no 460 0.11970787982882 605 21368410
SGTC_2904 7225135 42.03 µM 1.17582802918838 0.123878874973468 no 461 0.119831801679798 664 4446116
SGTC_1625 st003711 30.1 µM 1.17556004443514 0.123931330954945 no 462 0.119885364936399 629 24207034 YER133W GLC7
SGTC_2486 5283202 22.39 µM 1.17390117995488 0.124256387044107 no 463 0.120217304894676 604 1377751
SGTC_1920 st075728 45.7 µM 1.17316036926138 0.124401742067124 no 464 0.120365750612405 637 3400306
SGTC_1202 1988-0068 29.6 µM 1.17270511711181 0.124491126398088 no 465 0.120457039338715 663 2850480
SGTC_2912 7964298 10.93 µM 1.17144308716018 0.124739148445565 no 466 0.120710360834773 705 2975850
SGTC_299 1273-0059 1.44 µM 1.16961697561703 0.125098638354121 no 467 0.121077571383714 612 2848077
SGTC_2701 st077767 14.721 µM 1.1693809871887 0.125145147982991 no 468 0.121125083288429 697 5721188
SGTC_795 0685-0265 78 µM 1.16750943030747 0.125514430222224 no 469 0.121502351110066 659 302754
SGTC_2180 6301957 200 µM 1.16502962437111 0.126004898190339 no 470 0.122003500799876 652 845462
SGTC_1086 cerivastatin 2.18 µM 1.16423043582024 0.126163249911435 no 471 0.122165319540581 620 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_325 2810-4341 181 µM 1.16420193204859 0.12616890022742 no 472 0.122171093731942 634 774970
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.16407086667013 0.126194883648941 no 473 0.122197646950319 701 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_617 3770-0098 35 µM 1.16366903663973 0.126274568809788 no 474 0.12227908104397 615 5962639
SGTC_2417 cerulenin 830 nM 1.16345128165808 0.126317765497734 no 475 0.122323226757735 612 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_583 1488-1091 88.9 µM 1.16340757541934 0.126326436871895 no 476 0.12233208872079 769 4303273
SGTC_675 1309-0189 238 µM 1.15899181216627 0.127204668815797 no 477 0.123229761273132 652 4246530
SGTC_2271 7849410 118.62 µM 1.15857583465029 0.127287619166795 no 478 0.123314561880509 663 972430
SGTC_3057 9095946 49.47 µM 1.15828219719425 0.127346196256601 no 479 0.123374447023205 658 24540043
SGTC_2203 7227154 166.4 µM 1.15825348717182 0.127351924561873 no 480 0.123380303308801 607 896304
SGTC_1431 4049-0260 9.09 µM 1.15490310014224 0.128021634439402 no 481 0.12406505487775 665 3854841
SGTC_431 k089-0097 107 µM 1.15370308140718 0.128262100582219 no 482 0.124310960084254 721 5499420
SGTC_648 0375-0473 33.3 µM 1.15080184953388 0.128844760065256 no 483 0.124906881865722 698 1713139
SGTC_1607 st000305 50.6 µM 1.14894397295505 0.129218843585161 no 484 0.125289541973229 666 5457690
SGTC_1561 5-methoxyflavone 52.9 µM 1.14702806313634 0.129605399914706 no 485 0.125685011390133 605 94525
SGTC_1873 rapamycin 2 nM 1.14642449464458 0.129727342389749 no 486 0.125809776196665 706 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1135 dihydrocapsaicin 536.708 nM 1.13752857508208 0.131533856168967 no 487 0.127658693011181 653 107982 A Capsaicinoid.
SGTC_737 1950-0117 57.9 µM 1.13250256415756 0.132562140778523 no 488 0.128711603486956 670 5393513
SGTC_3301 9125354 19.7965 µM 1.12978763994441 0.133119892055065 no 489 0.129282858803792 602 41905162
SGTC_2690 usnic acid 100 µM 1.12875421627741 0.133332621363548 no 490 0.129500765632931 749 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_514 4466-0038 2.65 nM 1.12765935275674 0.133558253028896 no 491 0.129731905081523 743 5722064
SGTC_623 k072-0108 16.9 µM 1.12670167837297 0.133755827652555 no 492 0.129934316296999 675 5382803
SGTC_3174 9107204 49.47 µM 1.12598726867055 0.133903345932259 no 493 0.130085454118647 658 3938802
SGTC_2516 gossypol 71.55 µM 1.12590510210869 0.133920319651746 no 494 0.130102844764899 723 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1413 3910-0535 34.4 µM 1.1253914440789 0.134026463086302 no 495 0.130211597539663 717 2876951
SGTC_1626 st003712 1.76 µM 1.12537066191641 0.134030758774772 no 496 0.13021599890702 644 24207035
SGTC_733 4069-0007 56.1 µM 1.12509331844025 0.134088094933135 no 497 0.130274746176557 747 5717425 YNL287W SEC21
SGTC_2499 avocadenofuran 51.48 µM 1.12411679296322 0.134290109467485 no 498 0.130481741055133 653 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_810 3825-7150 143 µM 1.12366514640998 0.13438361257302 no 499 0.130577553820402 736 22330411 YGL099W LSG1
SGTC_328 k915-0120 63.5 µM 1.12360267755173 0.134396548841932 no 500 0.130590809857083 674 6624543
SGTC_2514 salinomycin 42.74 µM 1.12072109243354 0.134994207094109 no 501 0.131203300532448 773 23682228 A polyether potassium ionophore.
SGTC_1000 4048-0884 8.67 µM 1.12012927026407 0.13511717989769 no 502 0.131329339531753 684 13040088
SGTC_513 4245-1575 41.7 µM 1.11650793394987 0.135871318481037 no 503 0.132102387993819 807 719745
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.11327012144158 0.136548024912901 no 504 0.132796217338963 668 688803
SGTC_1962 st076595 64.5 µM 1.11224626404962 0.136762491115513 no 505 0.133016140586285 697 279619
SGTC_1442 4112-3290 3 µM 1.11215810607093 0.136780968225108 no 506 0.133035088522791 716 704353
SGTC_257 daunorubicin 18.5 µM 1.11138070550099 0.13694397817993 no 507 0.133202256911238 687 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1013 4112-3890 241 µM 1.11135103920496 0.136950201413282 no 508 0.133208639067444 705 705171
SGTC_189 3970-0742 2.116 µM 1.10954271694996 0.137329906337161 no 509 0.133598063613873 683 2891807
SGTC_2273 7815444 169.05 µM 1.10549037719912 0.138183410652989 no 510 0.134473580886459 674 2824616
SGTC_448 monastrol 171 µM 1.10363907325712 0.138574533589053 no 511 0.134874867285889 699 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1923 st058458 19.1 µM 1.09918797163688 0.139517997391555 no 512 0.135843042104434 765 3534982
SGTC_447 ml7 120 µM 1.09562911397065 0.140275475465115 no 513 0.13662055770725 723 4216 Selective myosin light chain kinase inhibitor.
SGTC_1959 st077091 55.8 µM 1.09267201463923 0.140906994324781 no 514 0.137268915647771 729 821356 YKL052C ASK1
SGTC_1927 st060202 13.8 µM 1.09148771828412 0.141160452996991 no 515 0.137529166594364 705 688887
SGTC_2600 tangeritin 87.95 µM 1.0913824261345 0.141183002182825 no 516 0.137552321000038 669 68077 A bioactive flavone.
SGTC_98 0074-0023 107.663 µM 1.09089011574693 0.141288466933721 no 517 0.137660618457233 749 3563821
SGTC_3099 9120367 49.47 µM 1.09060846491117 0.141348827341564 no 518 0.137722601608415 706 24824940
SGTC_2709 st078560 56 µM 1.0893091983641 0.141627498576857 no 519 0.138008778906567 736 17250903
SGTC_2409 alverine citrate 63.97 µM 1.08844207191403 0.141813689847662 no 520 0.138199998259199 703 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1211 1056-0033 32.3 µM 1.08677613888398 0.142171867579333 no 521 0.138567877718674 747 6741922
SGTC_997 3996-0078 137 µM 1.08544872440834 0.142457701283304 no 522 0.138861481066342 723 735687
SGTC_2925 9010536 32.5 µM 1.08461030621002 0.142638439003302 no 523 0.139047144208257 785 2994177
SGTC_2441 5730946 39.09 µM 1.08277206943907 0.143035249936616 no 524 0.139454802910642 727 1774275
SGTC_1376 2910-0861 41.3 µM 1.08153987760434 0.143301654152557 no 525 0.139728516028861 738 1112859
SGTC_2247 cerulenin 830 nM 1.08120219396932 0.143374721004137 no 526 0.139803591153583 724 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2355 9061122 103.12 µM 1.07999386094495 0.143636382079599 no 527 0.140072456975386 731 5302957
SGTC_709 3807-1509 243 µM 1.07933635758421 0.143778897873736 no 528 0.140218905349486 724 1886677 YPL242C IQG1
SGTC_78 0336-0123 156.75 µM 1.07748204522163 0.144181339364033 no 529 0.140632483915802 669 6765896
SGTC_1960 st011366 51.8 µM 1.07420379003971 0.144894675779981 no 530 0.141365677047752 720 3972846
SGTC_3312 9133330 71.43 µM 1.07302542228595 0.14515166390996 no 531 0.141629854967526 788 17617324
SGTC_2802 7925815 54.55 µM 1.07211901453297 0.145349549359877 no 532 0.141833289684715 729 1262923
SGTC_3051 9093778 49.47 µM 1.07038223086594 0.145729227929912 no 533 0.142223647093207 668 17217378
SGTC_1439 4092-1168 46 µM 1.06910186444078 0.146009555596203 no 534 0.142511885816757 757 2886240
SGTC_843 0310-0051 143 µM 1.06899206282089 0.146033612782682 no 535 0.142536622963824 736 2065037
SGTC_2606 farnesol 9.78 µM 1.06881735924617 0.146071895270543 no 536 0.142575987822452 750 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2681 menadione 3.18 µM 1.06678734558848 0.146517222900471 no 537 0.143033937067313 727 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1328 1441-0025 69.2 µM 1.06323490265697 0.147298719125224 no 538 0.143837718984945 697 4562601
SGTC_693 4161-2696 114 µM 1.06303328914632 0.147343155379398 no 539 0.143883427607852 678 805759
SGTC_1703 st026983 48.3 µM 1.06023700247014 0.147960392150897 no 540 0.144518395570888 794 1104023
SGTC_3169 9102970 49.47 µM 1.06019620874199 0.147969409522025 no 541 0.144527672774709 743 17027839
SGTC_327 1273-0057 3.96 µM 1.05664591079796 0.148755604957777 no 542 0.145336609553713 709 3108138
SGTC_2330 7979373 200 µM 1.05237542369349 0.14970497508563 no 543 0.146313669838319 744 1863007
SGTC_861 0443-0273 110 µM 1.04975090436989 0.150290432013452 no 544 0.146916326501175 761 6149169
SGTC_3030 9087619 49.47 µM 1.04816149206555 0.150645726305647 no 545 0.147282104479025 720 25236973
SGTC_2132 5317594 122.667 µM 1.04372341791806 0.151640764570555 no 546 0.14830668600936 697 794577
SGTC_1474 0330-0125 5.35 µM 1.0432378302985 0.151749900259436 no 547 0.148419078295393 767 X1474
SGTC_504 lovastatin 124 µM 1.0405448980949 0.152356083246338 no 548 0.149043408000687 684 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2480 5767542 37.17 µM 1.04023762332584 0.15242535326844 no 549 0.149114757964729 780 2867358
SGTC_1185 1319-0113 81.3 µM 1.03977319431707 0.152530090783499 no 550 0.149222642825587 708 4672763
SGTC_3114 9122766 49.47 µM 1.03921372694652 0.152656324642799 no 551 0.149352673885925 695 17176985
SGTC_1782 st039423 80.636 µM 1.03536824998394 0.153525862974183 no 552 0.1502484837077 706 2068169
SGTC_1985 st071382 65.5 µM 1.03048079047803 0.154635738906707 no 553 0.151392182587334 786 6123237
SGTC_2224 6650123 117.647 µM 1.02946997279157 0.15486594199349 no 554 0.151629441427756 730 2908370
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.02887926402725 0.155000574439462 no 555 0.151768206778355 727 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3193 9111931 49.47 µM 1.02807612159936 0.155183748032172 no 556 0.151957010950931 767 17087244
SGTC_2307 7538926 6.34 µM 1.0257662969575 0.155711348480373 no 557 0.152500877978257 780 96582
SGTC_455 paf C-16 10 µM 1.02507815066809 0.155868760404226 no 558 0.152663157054272 746 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1652 st011932 78 µM 1.025028298017 0.155880168160536 no 559 0.152674917785113 762 1551076
SGTC_362 0310-0100 9.03 µM 1.02450560539145 0.155999808781344 no 560 0.1527982623022 735 790235
SGTC_2349 9023730 187.07 µM 1.02423545462508 0.156061668086019 no 561 0.152862038125455 770 4126287
SGTC_340 k038-0059 454 µM 1.02278475422915 0.156394126882655 no 562 0.153204813982141 797 23733424
SGTC_2603 homopterocarpin 100 µM 1.02189109522898 0.156599159815185 no 563 0.153416223759516 769 101795 A weak amylase inhibitor.
SGTC_1775 st081588 35.1725 µM 1.02088201604698 0.156830886315712 no 564 0.153655170268142 812 1426443 YGL099W LSG1
SGTC_1548 st061468 90.8 µM 1.02065345569259 0.156883404593685 no 565 0.153709326789094 818 390799
SGTC_2687 chenodiol 100 µM 1.02058343922493 0.156899495194574 no 566 0.153725919457338 731 5702181 A cholesterol synthesis inhibitor.
SGTC_391 gliotoxin 8.33 µM 1.02039719990787 0.156942300446876 no 567 0.153770060663146 832 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2135 5326629 150.42 µM 1.01790022086614 0.157516948175928 no 568 0.154362688333247 711 5020077
SGTC_20 0481-0013 4.944 µM 1.01741249445614 0.15762935337014 no 569 0.154478620337547 784 182045
SGTC_1633 st005664 67.9 µM 1.01674147198145 0.157784088499545 no 570 0.15463821564829 781 2063822
SGTC_753 1322-0200 289 µM 1.01189547082027 0.158904518044658 no 571 0.155794017533878 807 5403907
SGTC_2875 9039966 71.43 µM 1.01073177639766 0.159174346875584 no 572 0.156072411962387 775 6463691
SGTC_607 4491-0986 66.8 µM 1.00888289244388 0.15960366921559 no 573 0.156515400329822 822 698981 YDR232W HEM1
SGTC_1158 4092-0494 91.8 µM 1.00589973837767 0.160297972467799 no 574 0.157231901064307 833 1148199
SGTC_2575 plumbagin 510 nM 1.00455717925236 0.160611084603884 no 575 0.157555062567127 769 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1622 st003707 19.4 µM 1.00359863872538 0.160834880037715 no 576 0.157786055493136 824 10140899
SGTC_3008 9078912 71.4286 µM 1.00325066952534 0.160916172557758 no 577 0.157869965503448 771 16648731
SGTC_1710 st031758 61.5 µM 1.00095226264838 0.16145379962061 no 578 0.158424943958509 777 5394341
SGTC_1417 3966-0327 90.4 µM 0.99962652195563 0.161764439529976 no 579 0.158745641560191 857 651118
SGTC_2022 5136654 200 µM 0.997414919102895 0.162283515790835 no 580 0.159281576330183 768 1713771
SGTC_2354 9060492 162 µM 0.996491795864914 0.162500498674021 no 581 0.159505625651621 866 6471895
SGTC_1547 harmine 94.2 µM 0.996440288036461 0.162512611301689 no 582 0.159518133083092 876 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1038 k292-0204 154 µM 0.99635963992317 0.162531577765226 no 583 0.159537717818032 743 4454212
SGTC_1791 st048313 56.1 µM 0.996113245944058 0.162589532523935 no 584 0.159597562330373 758 1204976
SGTC_1367 1812-0510 76.9 µM 0.995647005968628 0.162699234430578 no 585 0.159710843541847 787 1142582 YDR527W RBA50
SGTC_1130 3454-2858 15.9 µM 0.995295199045074 0.162782043173538 no 586 0.159796356046736 772 715628 YIL048W NEO1
SGTC_187 1488-2104 32.728 µM 0.994990534709967 0.162853777579779 no 587 0.15987043396094 832 2852859
SGTC_760 0568-0725 82.9 µM 0.990085991621342 0.164011399820387 no 588 0.16106604488286 873 3916171
SGTC_375 3970-0961 9.27 µM 0.986922915807629 0.164760807272929 no 589 0.161840214599505 821 2898222
SGTC_3158 9100007 49.47 µM 0.985334505112021 0.165137974659076 no 590 0.1622298945568 733 19297233
SGTC_1085 doxorubicin 7.67 µM 0.981347095441672 0.166087243633372 no 591 0.163210802851546 876 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3247 9135149 49.47 µM 0.980710440961822 0.166239135535363 no 592 0.163367776796321 767 8934436 YOR116C RPO31
SGTC_550 4123-0385 25.7 µM 0.980546438404175 0.166278277504289 no 593 0.163408229254866 804 5731123
SGTC_1044 1222-0021 1.78 µM 0.980411522320182 0.166310481958981 no 594 0.163441512194301 806 4306703
SGTC_3267 9137951 49.47 µM 0.980343049253115 0.166326828013521 no 595 0.163458405748519 803 16643986
SGTC_666 0272-0154 136 µM 0.980185153134459 0.166364525307553 no 596 0.163497365922822 829 6870312
SGTC_845 0330-0138 4.51 µM 0.979991717178908 0.166410715165503 no 597 0.163545103614843 816 9039800
SGTC_2561 acetosyringone 100 µM 0.978798955851055 0.166695713161354 no 598 0.163839662871348 935 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1834 st055981 52.8 µM 0.978019526996706 0.166882119687922 no 599 0.164032333194344 845 471719 YDL150W RPC53
SGTC_258 haloperidol 50.781 µM 0.976651997508683 0.167209499878325 no 600 0.164370733646785 797 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_521 r062-0005 13.8 µM 0.975673870283527 0.167443912763327 no 601 0.164613052437633 795 2832033
SGTC_984 1492-0255 2.91 µM 0.970643779767445 0.168652740427209 no 602 0.165862848441128 783 1585198
SGTC_3035 9091303 49.47 µM 0.968991661100551 0.169050997064509 no 603 0.166274674897561 843 25237002
SGTC_3000 9075062 71.4286 µM 0.967107710778991 0.169505875045369 no 604 0.16674509561908 788 17057871
SGTC_1147 3809-1045 12.3 µM 0.965690099303421 0.169848673287412 no 605 0.167099637583142 804 325925
SGTC_2895 9054447 58.44 µM 0.965110426587575 0.16998897419708 no 606 0.167244752548563 804 2697450
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.964372095151083 0.170167783562048 no 607 0.167429703643739 815 641818 YHR062C RPP1
SGTC_1490 4089-0339 670 nM 0.963106113704159 0.170474659779718 no 608 0.167747136995016 811 742542
SGTC_2040 5100729 123 µM 0.961019053215215 0.1709813402501 no 609 0.16827129393139 853 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_42 0133-0086 60.653 µM 0.959834649081668 0.171269308811004 no 610 0.168569220392208 777 162923 Model of phenazepam hydroxylation.
SGTC_1090 efavirenz 20.7 µM 0.958599864683495 0.171569856461266 no 611 0.168880180379666 851 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1605 st000082 49.1 µM 0.957599823204834 0.171813514300483 no 612 0.169132294177598 858 1114022
SGTC_51 1013-0126 23.419 µM 0.957123892834952 0.171929551230386 no 613 0.169252362647693 811 1627850
SGTC_2482 5981709 142.65 µM 0.954922854202783 0.172466838656483 no 614 0.169808355666209 850 877755
SGTC_482 fipronil 114 µM 0.954813920104701 0.172493457939808 no 615 0.169835903330271 838 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2871 9038510 12.99 µM 0.952925380459445 0.172955360463532 no 616 0.17031393975572 880 4945164
SGTC_76 0433-0009 400.328 µM 0.950599932385269 0.173525204442312 no 617 0.170903751487932 754 2841569
SGTC_317 4495-0002 170 µM 0.950306517542834 0.173597189654002 no 618 0.170978264088942 800 15991618
SGTC_2457 5731572 11.68 µM 0.949100869716479 0.173893177835432 no 619 0.171284656057334 876 2865357
SGTC_2850 9015429 58.44 µM 0.94788468156417 0.17419207863236 no 620 0.171594082057564 800 6457570
SGTC_2242 6630449 61.2675 µM 0.947814909435463 0.174209236324952 no 621 0.171611844503988 747 691249 YDR170C SEC7
SGTC_1484 3473-2379 286 µM 0.944563672163795 0.175009940281309 no 622 0.172440840425628 1016 671917
SGTC_1847 st056231 15 µM 0.943080562294073 0.175375969941812 no 623 0.172819848605574 905 5393180
SGTC_1384 3089-0840 101 µM 0.942542053239675 0.175508993322344 no 624 0.172957595677998 826 1069836
SGTC_1379 2144-0755 36.5 µM 0.942180196207599 0.175598415748175 no 625 0.173050195610829 917 5392327
SGTC_2812 7970281 58.44 µM 0.941758397946317 0.175702687337882 no 626 0.17315817447799 864 2233435
SGTC_2303 7774051 200 µM 0.938466128644971 0.176517907765562 no 627 0.174002457897858 824 2953184
SGTC_476 mead acid 10 µM 0.938360179699946 0.176544182151372 no 628 0.174029671288907 831 5312531 An omega 9 fatty acid.
SGTC_1206 3978-0017 132 µM 0.938194754853291 0.176585210971758 no 629 0.174072166702591 812 3873677
SGTC_2816 7982706 58.44 µM 0.938177998158008 0.176589367318822 no 630 0.174076471639683 811 2981853
SGTC_2557 derrustone 83.84 µM 0.936897613238097 0.176907138202838 no 631 0.174405613525066 911 629853 An antioxidant.
SGTC_2485 5633444 17.78 µM 0.936389548533613 0.177033331755057 no 632 0.17453632856382 833 5724239
SGTC_719 2810-4230 27.3 µM 0.933461570479651 0.177761693414967 no 633 0.175290851668867 849 721079
SGTC_1990 st072050 59.8 µM 0.93321348647838 0.177823493363022 no 634 0.175354876397847 875 17233948
SGTC_689 0833-0039 98 µM 0.933065284812255 0.177860418191648 no 635 0.17539313088503 900 5374726
SGTC_1037 k284-1091 78.7 µM 0.932065720907871 0.178109588414551 no 636 0.17565128102178 807 3334711
SGTC_1863 st057641 20.1 µM 0.932037731697267 0.178116568700806 no 637 0.175658513056015 943 3921635
SGTC_856 0433-0016 11.3 µM 0.931174123519187 0.178332030450061 no 638 0.175881750467103 886 3911780
SGTC_1355 1499-0035 1.68 µM 0.927489741090816 0.179253091446832 no 639 0.176836157910115 855 1548538
SGTC_1162 k048-0130 20.1 µM 0.92714399347051 0.179339678387853 no 640 0.176925888547778 865 6797406
SGTC_721 1187-1332 279 µM 0.922779291019875 0.180435008709504 no 641 0.178061117501804 790 25730
SGTC_2811 7967822 32.47 µM 0.922506182046006 0.180503685156444 no 642 0.178132303599616 873 2232244
SGTC_582 0987-0078 156 µM 0.921546839383355 0.180745053021269 no 643 0.17838249928203 999 1625765
SGTC_2873 9040596 71.43 µM 0.920503861869059 0.18100769263614 no 644 0.178654757925001 869 6463863
SGTC_2294 7971431 200 µM 0.918850950216614 0.181424413628011 no 645 0.17908676926299 787 5741572
SGTC_1563 conessine 56.1 µM 0.918245521866949 0.18157720032669 no 646 0.179245170653359 1005 441082 An anti-amoebic, histamine inhibitor.
SGTC_2450 5739737 12.93 µM 0.915407086077968 0.182294585012594 no 647 0.179988979874192 835 2262825
SGTC_2274 7947094 46.08 µM 0.914714482215117 0.182469901778739 no 648 0.180170769761255 966 2971028
SGTC_3238 9133470 49.47 µM 0.914394576956479 0.182550913996271 no 649 0.180254775184357 902 3534688
SGTC_224 benfluorex 43.875 µM 0.912207839445807 0.183105280782483 no 650 0.18082965895147 868 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_869 0564-0080 44.1 µM 0.912013459285842 0.183154609489519 no 651 0.180880816209394 862 6843321
SGTC_1765 st044815 90.4 µM 0.910975787719831 0.183418084178242 no 652 0.181154065583945 875 645695
SGTC_956 1185-0240 191 µM 0.910844773901187 0.183451366625456 no 653 0.181188583741803 879 1416193
SGTC_2234 tolnaftate 200 µM 0.910075261830579 0.183646927676055 no 654 0.181391409926646 876 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_110 0850-0284 111.64 µM 0.907214431069164 0.184375107538092 no 655 0.18214670690181 766 3906265
SGTC_2998 9066762 71.4286 µM 0.907164454044203 0.184387844354142 no 656 0.182159918941657 909 4945196
SGTC_773 4358-1457 44.6 µM 0.905947926809462 0.184698049302749 no 657 0.18248170758483 960 1186886
SGTC_1921 5740136 50 µM 0.905684946896651 0.184765149753776 no 658 0.182551316135188 942 1774243
SGTC_982 1491-0518 27.5 µM 0.903286225671668 0.185377893038781 no 659 0.183187002552176 854 3091256
SGTC_703 3875-0075 71.8 µM 0.900825856282743 0.186007693023016 no 660 0.183840458842306 963 2850814
SGTC_3280 9140961 49.47 µM 0.900134039252472 0.186185021503511 no 661 0.184024461630071 870 4901226
SGTC_1023 4482-3888 16 µM 0.899332194756257 0.186390683573792 no 662 0.184237871868391 904 3303168
SGTC_1870 st057514 26.5 µM 0.898112121384663 0.186703885444703 no 663 0.184562888700709 891 5393161
SGTC_2755 lomerizine 42.69 µM 0.897971652192421 0.186739965829467 no 664 0.184600331336287 929 3949 A calcium channel blocker.
SGTC_312 4092-0653 6.84 µM 0.897628937071684 0.186828012446795 no 665 0.184691703267375 979 1148278
SGTC_121 0557-0495 61.343 µM 0.897610207171153 0.186832825068129 no 666 0.184696697692046 1126 3104427
SGTC_2136 5328288 199.296 µM 0.896984873254121 0.186993547769805 no 667 0.184863494407816 797 262395
SGTC_463 ikarugamyin 104 µM 0.894946085562828 0.187518148761784 no 668 0.185407954694159 927 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_611 3453-1652 23.7 µM 0.89315777645055 0.187979047014577 no 669 0.185886343036712 964 1560575
SGTC_860 0443-0016 25.1 µM 0.892033302735998 0.188269213774745 no 670 0.186187541216687 987 5337942
SGTC_473 2-arachidonoylglycerol 10 µM 0.890578175347577 0.188645114564223 no 671 0.18657775596192 879 5282280 An endocannabinoid.
SGTC_1016 4226-1401 38 µM 0.885765387158317 0.189891687100226 no 672 0.187871982550451 926 2901613
SGTC_2512 diallyl trisulfide 49.23 µM 0.885088104067112 0.190067517526444 no 673 0.188054557458277 908 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3285 9112818 20.8695 µM 0.885013817200201 0.190086809333078 no 674 0.188074589599481 967 17017947 YPR165W RHO1
SGTC_396 dithiazanine 1.25 µM 0.884851326622576 0.190129011253 no 675 0.188118411278705 897 10578 An antihelmenthic.
SGTC_1817 st052116 64.4 µM 0.884057284268027 0.190335322083919 no 676 0.188332645210016 917 4361398
SGTC_3143 9086658 49.47 µM 0.883829477716749 0.190394536944436 no 677 0.188394135564535 970 25236626
SGTC_2388 9080168 200 µM 0.883764291606511 0.190411483167563 no 678 0.188411733109702 860 15943073
SGTC_1766 st045414 44.774 µM 0.883485617726979 0.190483939562328 no 679 0.18848697492594 991 253960
SGTC_2166 5933061 31.504 µM 0.882938292691054 0.190626295670337 no 680 0.188634806354244 955 2877375
SGTC_2889 9059656 51.95 µM 0.878476945988748 0.191789100525721 no 681 0.189842471660778 975 3949838
SGTC_1884 5633444 25 µM 0.876859408510222 0.192211765784723 no 682 0.190281503055123 940 5724239
SGTC_516 3992-2719 87.3 µM 0.876688632042035 0.19225642319313 no 683 0.190327891510558 957 5350887 YDR037W KRS1
SGTC_3148 9097893 49.47 µM 0.876455947346904 0.192317279584676 no 684 0.190391107437253 909 17174100
SGTC_892 0929-0076 29 µM 0.874591686333211 0.192805283901253 no 685 0.19089805646944 965 5751038
SGTC_471 1-acyl-paf 4 µM 0.874145394256343 0.192922221124086 no 686 0.19101953953941 909 16759367
SGTC_1247 0448-0043 5.84 µM 0.87405657561621 0.192945498506134 no 687 0.191043722100086 957 3089013 YGL099W LSG1
SGTC_1128 3448-9350 235 µM 0.873118995659823 0.193191321883698 no 688 0.19129911054246 837 619386
SGTC_2089 5281248 129.67 µM 0.869827077859224 0.194055940218098 no 689 0.19219745566978 916 2737878
SGTC_261 5-fluorouridine 15.376 µM 0.869595992090041 0.194116723049205 no 690 0.19226061441522 935 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2854 9024559 71.43 µM 0.869113933178078 0.194243557042346 no 691 0.192392408240193 921 3163529
SGTC_2842 9000675 19.48 µM 0.866738654968063 0.194869250573974 no 692 0.193042610337498 893 2989072
SGTC_3296 9122258 64.045 µM 0.866519528771396 0.194927034277591 no 693 0.193102660861778 939 4730474
SGTC_2881 9058953 51.95 µM 0.864347247142734 0.195500429623974 no 694 0.193698581367721 1001 17122249
SGTC_1112 tnp00069 1.16933 µM 0.862929486006651 0.19587521362392 no 695 0.194088118842428 994 145826
SGTC_2846 9008642 19.48 µM 0.862443141594731 0.196003878735652 no 696 0.194221854435641 902 2992898
SGTC_2088 5278280 127.392 µM 0.860009937185946 0.196648366024137 no 697 0.194891782393739 974 791502
SGTC_895 0964-0006 13.7 µM 0.853891649783294 0.198274590684604 no 698 0.196582513330592 971 6738897
SGTC_3 0833-0587 95.581 µM 0.853559382953699 0.19836313809227 no 699 0.196674585819215 949 5382644
SGTC_1440 4100-1550 40 µM 0.852547735204853 0.198632883932013 no 700 0.196955078318152 1001 742806
SGTC_1857 st056007 79.3 µM 0.852481489578683 0.198650555385331 no 701 0.196973454223732 957 619834
SGTC_2727 riluzole 51.77 µM 0.851654446052159 0.198871254442189 no 702 0.197202955564949 941 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3298 9116858 71.43 µM 0.850878209371628 0.199078529935413 no 703 0.197418505317651 986 2506942
SGTC_2966 9084041 48.03 µM 0.845937263295605 0.200400940119274 no 704 0.198793871712306 911 17741380
SGTC_47 0149-0135 24.25 µM 0.845902842502248 0.2004101710767 no 705 0.198803473333309 993 5239155
SGTC_729 4092-0585 94.1 µM 0.845361684399166 0.200555332255897 no 706 0.198954465201039 939 2169061
SGTC_1263 0774-1208 64.8 µM 0.845352272191926 0.200557857561021 no 707 0.19895709197049 1025 906585
SGTC_1748 st037455 53.6035 µM 0.843683340540355 0.201005935482128 no 708 0.199423189657986 949 580690
SGTC_3236 9132701 49.47 µM 0.842326088697387 0.201370775410591 no 709 0.199802725941427 961 24282524
SGTC_1787 fluconazole 80 µM 0.841116170373128 0.201696345323984 no 710 0.200141428513842 954 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_698 k064-0052 127 µM 0.838974063980124 0.202273524924822 no 711 0.200741931990307 1003 5088751
SGTC_3332 9141069 11.198 µM 0.838184158084282 0.202486610104497 no 712 0.200963641456857 940 17332883
SGTC_3062 9077494 49.47 µM 0.836722247714397 0.202881329209082 no 713 0.201374355345994 953 16459633
SGTC_3129 9127257 49.47 µM 0.835928348152807 0.203095876321536 no 714 0.201597606728736 864 837894
SGTC_2171 5739187 198.077 µM 0.834680919601503 0.203433260724753 no 715 0.201948693738563 968 2262761
SGTC_2993 9054257 71.4286 µM 0.833189083106646 0.203837187398487 no 716 0.202369049259725 1047 6470217 YGL055W OLE1
SGTC_2264 7948757 110.76 µM 0.831939365073834 0.204175926227256 no 717 0.202721585379451 995 2971411
SGTC_1502 4534-4282 27.7 µM 0.830745933316978 0.204499721278366 no 718 0.203058585879244 963 3278949
SGTC_712 r015-0009 80.6 µM 0.830463204202719 0.204576474468547 no 719 0.203138471728927 930 6813872 YLR060W FRS1
SGTC_186 3455-3465 67.277 µM 0.830268619186778 0.204629308913409 no 720 0.20319346313172 949 755278
SGTC_2648 atorvastatin 78.68 µM 0.829585411036339 0.204814880404751 no 721 0.203386614004495 993 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2297 7971671 152.32 µM 0.828521367012613 0.205104092925303 no 722 0.203687649666408 988 909016
SGTC_2456 5770359 74.46 µM 0.827444392533728 0.205397067016556 no 723 0.20399261393189 1032 3118787
SGTC_876 0720-0963 56.8 µM 0.827383234186885 0.205413711644324 no 724 0.204009940152706 1021 765861
SGTC_445 e6 berbamine 66 µM 0.826060476646655 0.205773904391563 no 725 0.204384893200704 1054 6610268 A calcium/calmodulin antagonist.
SGTC_1227 3909-8010 46.6 µM 0.82403473843433 0.206326247796077 no 726 0.204959909908408 966 15982272
SGTC_3273 9137859 49.47 µM 0.82297243907354 0.206616248145864 no 727 0.20526183333092 1048 2377234
SGTC_117 lucigenin 22.078 µM 0.822801373691158 0.206662970364095 no 728 0.205310477690959 1053 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_268 camptothecin 39.6153 µM 0.82139444640815 0.207047474533342 no 729 0.205710812943205 1047 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2894 9048625 32.47 µM 0.818946341321735 0.207717533991078 no 730 0.206408514343347 1033 4092861
SGTC_2948 9070189 9.45 µM 0.818900285806295 0.20773015189593 no 731 0.206421653427299 923 6473636 YDL196W YDL196W
SGTC_339 3091-4833 71.4 µM 0.816103694653124 0.208497186693677 no 732 0.207220415496646 1001 3240077
SGTC_2824 7998404 51.95 µM 0.815748817281462 0.208594639922866 no 733 0.207321906071472 961 837851
SGTC_406 estrone 100 µM 0.815529554178233 0.208654865401547 no 734 0.207384627316023 1035 5870 A steroid.
SGTC_2172 5754775 163.918 µM 0.815215375100464 0.208741179522555 no 735 0.207474519273084 946 2263357
SGTC_2529 gangaleoidin 93.61 µM 0.813592400470316 0.209187392802148 no 736 0.207939246451144 1030 4565183
SGTC_1581 himbacine 57.9 µM 0.810857190758085 0.209940668298302 no 737 0.208723843435765 1000 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_586 0957-0265 8.15 µM 0.810641491915722 0.210000139395864 no 738 0.208785790945258 943 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1395 3486-0190 4.35 µM 0.806899812877017 0.211033345368405 no 739 0.209862103321875 1070 6748079
SGTC_2903 5923464 63.88 µM 0.805838625096228 0.21132691722863 no 740 0.210167951827406 1063 2876576
SGTC_3067 9117431 49.47 µM 0.801889457048766 0.212421532837514 no 741 0.211308452639112 1015 17150885
SGTC_2098 5376439 882.5 nM 0.801720958462691 0.212468310213214 no 742 0.211357194734055 1079 2844116
SGTC_2389 9091542 195.52 µM 0.800713792641103 0.212748037866072 no 743 0.211648677930292 1015 3626624 YOL127W RPL25
SGTC_2033 5192550 145 µM 0.799388776650827 0.213116371711861 no 744 0.212032508111339 1037 182073
SGTC_2075 5212009 200 µM 0.798254942627787 0.213431855081652 no 745 0.212361279741043 952 780898
SGTC_122 0236-0016 402.397 µM 0.798179962479619 0.213452727506139 no 746 0.212383031819264 1144 6808838
SGTC_612 0302-0167 22.4 µM 0.797494793818698 0.213643514840414 no 747 0.212581862626258 1099 235821
SGTC_3250 9135583 49.47 µM 0.796292278867615 0.21397859892928 no 748 0.21293108616381 1028 7699353
SGTC_1325 1431-0015 227 µM 0.794694078983721 0.214424414870134 no 749 0.213395738718066 981 1103340
SGTC_1419 3993-2473 62.6 µM 0.792875639909773 0.214932322572453 no 750 0.213925140668852 1059 704026
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.791432918977247 0.21533578518716 no 751 0.214345703285954 1067 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_414 piperonyl butoxide 100 µM 0.789165115489961 0.215970872886097 no 752 0.21500775398211 1043 5794 A potent inhibitor of cytochrome P450.
SGTC_1269 0831-0796 3.05 µM 0.788085844111441 0.21627349846979 no 753 0.215323247399489 1067 927758
SGTC_2957 9076800 11.52 µM 0.786928946612583 0.216598162720847 no 754 0.215661730656164 995 16459615
SGTC_135 0933-0004 26.348 µM 0.786906620996428 0.216604430809414 no 755 0.215668265682606 991 21230617 YGL099W LSG1
SGTC_1951 sophoraflavanone G 9.2 µM 0.785944436411023 0.216874671232645 no 756 0.21595001992355 1071 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_734 2023-0417 80 µM 0.785865695390922 0.216896795163414 no 757 0.215973086907321 1027 3935732
SGTC_2702 st077768 96.8 µM 0.784945202570621 0.21715552356248 no 758 0.21624284882793 971 6484119
SGTC_1694 st024011 44.9 µM 0.782815432095021 0.217754833870113 no 759 0.216867751999936 1113 2787533
SGTC_331 k048-0133 24.5 µM 0.782374579798182 0.21787900732264 no 760 0.216997234259961 1054 6813582
SGTC_2429 5902844 64.44 µM 0.782050620342587 0.217970281967587 no 761 0.217092412520511 1095 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2345 9052315 157.45 µM 0.781731305017519 0.218060269713163 no 762 0.217186249950873 1032 6469265
SGTC_2470 5664817 21.68 µM 0.781347400850409 0.218168487888804 no 763 0.217299099165177 1092 2859561
SGTC_2537 larixol 68.93 µM 0.780935172453626 0.218284724792588 no 764 0.21742031202426 1081 6708759
SGTC_2122 5258151 111.688 µM 0.780331622569179 0.21845497336225 no 765 0.21759785201898 1033 2173356
SGTC_3007 9078383 71.4286 µM 0.77941915241461 0.218712506904055 no 766 0.217866422672463 1069 6496995
SGTC_2593 nobiletin 86.24 µM 0.77888460633676 0.218863457127726 no 767 0.218023846321182 1022 72344 An anti-infammatory.
SGTC_788 1182-0090 188 µM 0.778761956801048 0.218898100526612 no 768 0.21805997581734 1139 5715185
SGTC_2436 5633522 8.09 µM 0.775734488265918 0.219754234069538 no 769 0.218952886001566 1087 5724242
SGTC_653 0203-0016 55.2 µM 0.774901195807763 0.219990216592889 no 770 0.219199022744711 1079 295302
SGTC_1017 4239-0030 168 µM 0.773810097527803 0.220299427618201 no 771 0.219521550171654 1072 1149593
SGTC_2267 7931562 200 µM 0.773041910809195 0.220517276742019 no 772 0.219748788731877 1000 934880
SGTC_2449 5812982 45.77 µM 0.772721505894049 0.220608176445302 no 773 0.219843608124631 1026 776185
SGTC_40 0327-0103 19.753 µM 0.7713222250717 0.221005407528514 no 774 0.220257981002124 1030 409036
SGTC_469 w7 172 µM 0.770595214518622 0.221211954463895 no 775 0.22047344929748 1127 45115570 A P450 inhibitor.
SGTC_65 0798-0905 34.986 µM 0.769484672549229 0.221527677456246 no 776 0.220802820083195 1125 3602145
SGTC_2344 7990960 76.95 µM 0.767487494638709 0.222096115415035 no 777 0.221395862773469 1027 140813
SGTC_2023 5144124 124 µM 0.767368615122912 0.222129977207164 no 778 0.221431191593587 1057 2830192
SGTC_987 1497-1013 404 µM 0.766099238842159 0.222491731626716 no 779 0.221808627935219 1089 1676435
SGTC_1762 st045503 25.4615 µM 0.766084472213896 0.222495941884366 no 780 0.221813020805733 1119 4645554
SGTC_1588 farnesol 29.9 µM 0.765901375680846 0.222548150099734 no 781 0.221867493655232 1063 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_893 0958-0369 48.9 µM 0.765405802147185 0.222689493159136 no 782 0.222014969514906 1109 6819948
SGTC_1473 k844-0725 134 µM 0.763874812118891 0.223126471520066 no 783 0.222470924418513 1188 54682906
SGTC_2069 5228469 200 µM 0.762689419454992 0.223465143841667 no 784 0.222824321043189 1063 2835210
SGTC_3134 9127454 49.47 µM 0.76168329354728 0.22375282810043 no 785 0.22312452434796 1131 24262820
SGTC_2047 4141938 200 µM 0.761472443887595 0.223813143578358 no 786 0.223187465890984 1047 3807862
SGTC_2962 9082311 13.18 µM 0.761237313229739 0.223880415756181 no 787 0.223257667567363 1090 16459453
SGTC_387 norethindrone acetate 66.7 µM 0.760998507233843 0.223948751228999 no 788 0.223328979432056 1037 541197
SGTC_295 k015-0027 31 µM 0.760800659430268 0.224005375295942 no 789 0.223388070243905 1074 3887424
SGTC_472 calcifediol 10 µM 0.760629677348226 0.224054316941378 no 790 0.223439144289296 1039 5283731 A vitamin D metabolite.
SGTC_1197 1601-0112 267 µM 0.76047212151373 0.224099420855594 no 791 0.223486213662131 1118 7350313
SGTC_3167 9103034 49.47 µM 0.759527840057769 0.224369850792188 no 792 0.223768433332296 1110 5127859
SGTC_377 3970-0964 33.1 µM 0.758737652347533 0.224596292571853 no 793 0.224004754253695 1140 16481235
SGTC_993 3909-8757 62.7 µM 0.757530270367725 0.224942538752695 no 794 0.22436611889337 1014 4288324 YLR208W SEC13
SGTC_82 0054-0107 293.755 µM 0.756862109921628 0.225134279999646 no 795 0.224566238807422 1097 3104697
SGTC_1289 0976-0073 69.1 µM 0.756712893166933 0.225177113207795 no 796 0.224610944363168 1106 3391136
SGTC_2416 tofa 880 nM 0.755920561336557 0.225404632241641 no 797 0.22484841268705 1012 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2100 5377183 190 µM 0.755333499365423 0.225573291697175 no 798 0.225024451719023 1147 2844202
SGTC_2630 antimycin a 100 µM 0.755302521053918 0.225582193567399 no 799 0.22503374318321 1155 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_947 3447-0010 211 µM 0.755298972735561 0.22558321321828 no 800 0.225034807460158 1149 748350
SGTC_3355 9151058 44.0485 µM 0.75506589083624 0.225650197747249 no 801 0.225104723920398 1131 17015728
SGTC_2655 perillic acid 100 µM 0.753630298242182 0.226063015331432 no 802 0.225535622999041 1098 5702197 An apoptosis inducer.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.753608154625566 0.226069386269116 no 803 0.225542273151387 1120 115019
SGTC_615 k087-0205 167 µM 0.753212735165861 0.226183169446457 no 804 0.225661043874665 1095 9642773
SGTC_49 0717-0965 32.132 µM 0.75133974584954 0.226722567381283 no 805 0.226224107498707 1211 5889349 YGL099W LSG1
SGTC_1428 4049-0204 61.7 µM 0.751297888256742 0.226734630140715 no 806 0.226236699914275 1147 X1428
SGTC_151 3013-0144 2.285 µM 0.750241442341088 0.227039202631964 no 807 0.226554651633554 1082 906558 YHR107C CDC12
SGTC_2695 st077686 51.995 µM 0.749694130572711 0.227197082835234 no 808 0.226719471675115 1116 2876092
SGTC_1745 st081495 74 µM 0.749637360269246 0.227213462613249 no 809 0.226736571623832 1107 13842402 YBL026W LSM2
SGTC_962 1254-0300 21.5 µM 0.749305243266488 0.227309300744715 no 810 0.226836624136364 1081 7340576
SGTC_1681 tripelennamine 100 µM 0.749271502065325 0.227319038628966 no 811 0.226846790296907 1112 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1326 1431-2094 10.8 µM 0.74655325520616 0.22810431049068 no 812 0.227666636923888 1105 616278
SGTC_92 0063-0024 660.874 µM 0.74500057490694 0.228553546545733 no 813 0.228135686167758 1191 3594437
SGTC_831 k061-1017 217 µM 0.744946486254199 0.228569204935342 no 814 0.228152035598896 1181 1240153
SGTC_2080 5212524 12.4 µM 0.74403134600674 0.228834224701039 no 815 0.228428755804481 1088 260183
SGTC_2862 9027634 71.43 µM 0.744012436709586 0.228839702551427 no 816 0.228434475587628 1092 5012562
SGTC_852 0418-0143 439 µM 0.743682687064419 0.228935239838948 no 817 0.228534232922203 1176 5369229
SGTC_2662 daunorubicin 22.37 µM 0.743665853437802 0.228940117590987 no 818 0.228539326162491 1090 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2228 7354201 200 µM 0.74339867343978 0.229017544116268 no 819 0.228620173603404 1153 753451
SGTC_1464 k208-0027 110 µM 0.742716561301183 0.22921528111479 no 820 0.228826650436388 1114 X1464
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.742371375946217 0.229315383121296 no 821 0.228931178671297 1146 688761
SGTC_2188 6126565 140.678 µM 0.741203459770043 0.229654254580823 no 822 0.229285042986201 1072 874518
SGTC_1160 4092-0570 10.5 µM 0.741168095945739 0.229664519785409 no 823 0.22929576257368 1115 4994975
SGTC_1278 0874-0585 172 µM 0.740434434962364 0.229877540579575 no 824 0.229518215440718 1136 766306
SGTC_515 4092-1064 102 µM 0.740192173351928 0.229947906291916 no 825 0.229591697974963 1161 717353
SGTC_1175 0741-0056 27.6 µM 0.739708046245308 0.230088558775321 no 826 0.229738582372944 1196 765927
SGTC_533 1222-0222 6.71 µM 0.738965696461177 0.230304325645811 no 827 0.229963913836832 1176 3982874
SGTC_1317 1273-0028 910 nM 0.73875489837168 0.230365615555972 no 828 0.230027921636768 1112 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2259 7964009 200 µM 0.736376104691147 0.23105788573258 no 829 0.230750921263591 1121 313134
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.736276170987128 0.231086993563671 no 830 0.230781322411939 1141 364106
SGTC_717 1532-0246 73.2 µM 0.735057845358298 0.231442021501652 no 831 0.231152132939457 1121 9561992
SGTC_1104 tacrolimus 29.8 µM 0.733472679718555 0.231904403922143 no 832 0.231635092471755 1168 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_676 falcarinol 140 µM 0.733436725064831 0.231914897622341 no 833 0.231646053456124 1170 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1797 st048695 56.8 µM 0.733435791918574 0.231915169973278 no 834 0.231646337935012 1111 592262 YIL048W NEO1
SGTC_1370 2001-0092 44.6 µM 0.733422047230111 0.231919181560972 no 835 0.231650528162111 1197 790957
SGTC_1286 0929-0070 131 µM 0.732410619341909 0.232214487564305 no 836 0.231958989537259 1168 1420408
SGTC_1199 1638-0010 4.46 µM 0.732222529587333 0.232269427084316 no 837 0.232016377636432 1127 3111136
SGTC_2785 7756463 72.73 µM 0.731021669739007 0.232620359120824 no 838 0.232382958491087 1155 2201551
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.730789929495123 0.232688115404098 no 839 0.232453737815343 1092 15053
SGTC_2769 toremifene 3.73 µM 0.730472830320151 0.232780846729073 no 840 0.232550607337243 1145 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_164 4100-3994 89.624 µM 0.730323206990166 0.232824609159193 no 841 0.232596323039631 1175 4615967
SGTC_2718 lomofungin 53.02 µM 0.73010247556084 0.232889177915929 no 842 0.232663774132128 1154 5351222 A RNA synthesis inhibitor.
SGTC_2735 sertaconazole 140 nM 0.729441574114371 0.233082565470742 no 843 0.232865797340812 1166 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2753 fluvastatin 17.09 µM 0.728457619708112 0.233370647251192 no 844 0.233166751287302 1131 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2381 9035592 200 µM 0.728402974303691 0.233386652099288 no 845 0.233183471548642 1089 4749657
SGTC_783 0848-0141 92.7 µM 0.72799719195989 0.233505518924125 no 846 0.233307652613358 1118 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1005 4092-0690 4.4 µM 0.727160624093812 0.233750682753637 no 847 0.233563782213646 1123 1529343
SGTC_1452 4194-0072 190 µM 0.727079756746921 0.233774389226063 no 848 0.233588549401345 1177 1343545
SGTC_838 0109-0203 71.4 µM 0.72611764480002 0.234056537053223 no 849 0.233883326485989 1164 759422
SGTC_2179 6298986 200 µM 0.725366120936565 0.23427705919818 no 850 0.234113725760156 1088 738374
SGTC_680 0417-1641 114 µM 0.722808038803576 0.235028547042671 no 851 0.234898913915488 1129 2835990
SGTC_395 anisomycin 6.25 µM 0.721674646191848 0.235361929060784 no 852 0.235247266760245 1114 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2137 5261020 140 µM 0.720842312031705 0.235606922311339 no 853 0.235503269603549 1163 763655
SGTC_941 3237-0776 460 µM 0.718338275676813 0.236344819960703 no 854 0.236274367621298 1154 760008
SGTC_1214 0358-0031 63.7 µM 0.717792542528709 0.236505807096695 no 855 0.236442606120613 1153 4301366
SGTC_1481 3346-2004 36 µM 0.717010646099779 0.236736565740864 no 856 0.236683763854925 1187 2770522
SGTC_2118 5526350 200 µM 0.716849622905491 0.236784103384095 no 857 0.236733444502671 1155 743594
SGTC_3097 9117246 49.47 µM 0.714539477366471 0.237466687517958 no 858 0.23744682705761 1208 16423892
SGTC_1835 st008666 49.2 µM 0.711449208308879 0.238381462995875 no 859 0.238402957399326 1088 690455
SGTC_152 4469-0003 551.229 µM 0.710789922881575 0.238576872863461 no 860 0.238607213071101 1158 697280
SGTC_2362 9071156 126 µM 0.710733481247678 0.238593606037299 no 861 0.238624703913352 1170 653133
SGTC_821 1114-0266 29.2 µM 0.710501088851949 0.238662509859018 no 862 0.23869672797888 1156 3123235
SGTC_840 0245-0196 390 µM 0.708427947604004 0.239277673159136 no 863 0.239339771028779 1230 3827528
SGTC_3026 9090633 49.47 µM 0.708123442069864 0.239368102007378 no 864 0.239434301619781 1184 25236842
SGTC_701 4424-0219 185 µM 0.707869264945459 0.239443599145543 no 865 0.239513223887199 1221 2911779
SGTC_651 3253-0966 34.4 µM 0.707183529482198 0.239647345048512 no 866 0.239726216309052 1200 781462
SGTC_322 k048-0136 19.3 µM 0.70308267422224 0.240867764923824 no 867 0.241002114406462 1196 6823282
SGTC_1453 4237-0541 195 µM 0.701875404082915 0.241227693236318 no 868 0.241378434480649 1170 739892
SGTC_1165 k072-0275 30.3 µM 0.701435522521922 0.241358909519819 no 869 0.241515629961896 1204 6153523 YGL055W OLE1
SGTC_3211 9128781 49.47 µM 0.701410319666299 0.241366428683901 no 870 0.241523491810075 1127 17194361
SGTC_2254 7938975 95.19 µM 0.699729662662272 0.241868132605366 no 871 0.24204807410667 1213 2969277
SGTC_1524 corynanthine 62.1 µM 0.699235597655027 0.242015726725688 no 872 0.24220240370879 1188 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2202 7226349 200 µM 0.699075024018544 0.242063706079835 no 873 0.24225257309597 1156 844334
SGTC_3241 9133421 49.47 µM 0.698928778003351 0.242107408832925 no 874 0.242298270883176 1195 17018221
SGTC_3300 9124615 50.48 µM 0.698686354852012 0.242179861659288 no 875 0.242374031623178 1202 24824903
SGTC_2749 bexarotene 57.39 µM 0.698495052674166 0.242237044294906 no 876 0.242433825379201 1184 82146 An retinoic acid receptor inhibitor.
SGTC_3166 9102297 49.47 µM 0.698455250368756 0.242248942626046 no 877 0.242446267064267 1160 25237072
SGTC_3302 9125395 16.351 µM 0.696174950430971 0.24293113438104 no 878 0.243159636512065 1175 17599668
SGTC_1676 st018489 23.4 µM 0.696027905168519 0.242975161196586 no 879 0.243205677098195 1182 3696235
SGTC_1968 st069590 43.6 µM 0.694649720221822 0.243388013219677 no 880 0.243637422492785 1158 6384066
SGTC_1275 0867-0008 21.1 µM 0.693654168168223 0.243686478559304 no 881 0.243949557370767 1181 3422836
SGTC_2713 st079149 53.4 µM 0.692650688998464 0.243987520304131 no 882 0.24426439583987 1215 3103253
SGTC_305 1682-2595 20.8 µM 0.692355090252994 0.24407623757609 no 883 0.244357180774465 1201 226033
SGTC_2683 piperine 63.03 µM 0.688255164071247 0.245308529852493 no 884 0.245646055439489 1170 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2319 6033012 152.6 µM 0.687440594481732 0.245553758180085 no 885 0.245902561928462 1167 847246
SGTC_899 1083-0020 478 µM 0.68496963407035 0.246298452270336 no 886 0.246681541473322 1245 767123
SGTC_3186 9110464 49.47 µM 0.684604917701428 0.24640847235489 no 887 0.246796631497068 1220 17018021
SGTC_1660 st012960 28.1 µM 0.68374666635971 0.246667475734224 no 888 0.247067574963705 1194 24207266
SGTC_2592 piperlongumine 83.33 µM 0.679897318712015 0.24783092437082 no 889 0.248284739755984 1191 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2974 9094440 9.66 µM 0.679246002158372 0.248028071341688 no 890 0.248491002006107 1247 25236134
SGTC_1600 coumarin 106 71.1 µM 0.679174496994327 0.248049720332013 no 891 0.248513652187414 1254 100336 A hepatotoxic, DNA x-linker.
SGTC_923 1900-2434 73.3 µM 0.678993846244408 0.248104418862981 no 892 0.248570880538206 1214 5910570
SGTC_2728 chlorpromazine 9.18 µM 0.677544780353412 0.248543408533071 no 893 0.249030184034528 1225 2726 A thorazine and dopamine antagonist.
SGTC_1051 3253-3903 78 µM 0.677403669379124 0.248586179732158 no 894 0.249074935421417 1214 5509239
SGTC_1354 1498-1681 81 µM 0.675689822395442 0.24910596523108 no 895 0.2496187995606 1272 5754243
SGTC_201 4262-0159 12.803 µM 0.675558267364651 0.249145887886524 no 896 0.249660572668907 1190 1341029
SGTC_3014 9081533 49.47 µM 0.675076551597473 0.249292101930408 no 897 0.249813565169617 1237 21367265
SGTC_2567 aureobasidin a 60 nM 0.674789448603777 0.249379267314211 no 898 0.249904772493724 1293 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_740 k014-0057 261 µM 0.674027832407613 0.249610574885892 no 899 0.250146809515173 1234 4012779
SGTC_2856 9022925 19.48 µM 0.673944319780621 0.24963594512144 no 900 0.250173356885405 1222 4944862
SGTC_757 1066-0008 322 µM 0.671632688596258 0.250338737081797 no 901 0.25090878136368 1242 6842497
SGTC_1516 st013856 110 µM 0.670531277736842 0.25067396126958 no 902 0.251259587292558 1225 5281404 A mutagen and neurotoxin.
SGTC_2984 9022109 38.96 µM 0.669366754772517 0.251028652594914 no 903 0.251630776677136 1280 6459207
SGTC_2698 st077697 67.5 µM 0.665063725368698 0.252341572713364 no 904 0.25300486742434 1192 3154499
SGTC_2465 5809242 33.21 µM 0.664126956800451 0.252627874186927 no 905 0.253304529139459 1244 2731748
SGTC_2508 celastrol 40.54 µM 0.664002943139863 0.252665788891792 no 906 0.253344213694219 1202 122724 Celastrol is a natural product and antioxidant.
SGTC_2168 5727979 200 µM 0.662865829065845 0.253013578531721 no 907 0.253708244196634 1188 695210
SGTC_259 usnic acid 108.925 µM 0.661212516436381 0.253519698000736 no 908 0.254238017760976 1320 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_182 3448-4371 550.524 µM 0.660624847215088 0.253699725991908 no 909 0.254426465165617 1279 3491403
SGTC_511 blebbistatin 171 µM 0.660031626477174 0.253881522713008 no 910 0.254616766985481 1305 3476986 A myosin inhibitor.
SGTC_24 0417-1663 219 µM 0.659937874147459 0.253910260037948 no 911 0.254646849017364 1232 4329390
SGTC_2193 5925765 200 µM 0.65955650243332 0.254027177158195 no 912 0.254769237811452 1255 877370
SGTC_75 0159-0059 199.013 µM 0.659554850050172 0.254027683790718 no 913 0.254769768156845 1358 5377270
SGTC_2404 5161160 200 µM 0.658195940477458 0.254444514630923 no 914 0.255206116511268 1226 2831543
SGTC_3220 9131269 49.47 µM 0.657874489949426 0.254543168503843 no 915 0.255309391987582 1288 17722206
SGTC_2207 7258803 200 µM 0.656498375071884 0.254965727585614 no 916 0.255751756362464 1213 3666799
SGTC_444 curcumin 90.4 µM 0.655949202037404 0.255134462757776 no 917 0.255928404565688 1231 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3149 9097855 49.47 µM 0.655039375744853 0.255414138270782 no 918 0.256221201338357 1262 25236625 YMR079W SEC14
SGTC_1888 azatryptophan 97.5 µM 0.653801968588558 0.255794767270921 no 919 0.256619699023247 1232 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1728 st035614 33.7865 µM 0.653351186614487 0.255933502283381 no 920 0.256764950140173 1275 15945546
SGTC_2598 perillyl alcohol 100 µM 0.652673772469842 0.256142060606089 no 921 0.256983307203392 1277 10819 An apoptosis inducer.
SGTC_2795 7780010 54.55 µM 0.652615200181485 0.256160097663186 no 922 0.257002191878339 1256 953673
SGTC_532 1548-0774 215 µM 0.651947265254924 0.256365831873133 no 923 0.257217596195338 1366 5932993
SGTC_1758 st042942 75.2445 µM 0.651137960684692 0.256615225434464 no 924 0.257478716930309 1231 669317
SGTC_3102 9121669 49.47 µM 0.650487254532946 0.256815837241164 no 925 0.25768876598391 1288 41905072
SGTC_3316 9136639 10.545 µM 0.648995532152118 0.257276041054256 no 926 0.258170632031435 1304 4903665
SGTC_486 niguldipine 82 µM 0.64886243337972 0.257317123510509 no 927 0.258213649167792 1266 1236 A calcium channel blocker.
SGTC_1371 2421-0008 32.7 µM 0.646481759131864 0.258052521281878 no 928 0.258983703275041 1263 2827552
SGTC_944 3370-0224 231 µM 0.645619210313254 0.258319234076162 no 929 0.259262996602635 1266 4580514
SGTC_2038 4100038 30.985 µM 0.644450281032651 0.258680912065991 no 930 0.259641744189691 1278 3596803
SGTC_768 0384-0033 77.3 µM 0.644033513523592 0.258809927316864 no 931 0.259776851071939 1257 3965305 YMR134W ERG29
SGTC_2261 9010538 184.68 µM 0.643357571850167 0.259019243731199 no 932 0.259996053639912 1204 6457250
SGTC_2057 5236571 38.335 µM 0.64236617609757 0.259326403964621 no 933 0.260317727942046 1280 54684039 YBR257W POP4
SGTC_764 1951-2361 146 µM 0.642179946315021 0.259384123793593 no 934 0.260378176058913 1250 5438930
SGTC_2627 acetyl isogambogic acid 100 µM 0.641632821797186 0.259553737275291 no 935 0.260555808409959 1234 6857789 A caspase activator and apoptosis inducer.
SGTC_2233 sulbentine 40.3845 µM 0.641486723319687 0.259599038793013 no 936 0.260603252069548 1268 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3310 9130229 44.1445 µM 0.640790125428159 0.259815092658223 no 937 0.260829524687494 1314 7761258
SGTC_610 4215-0184 155 µM 0.64025681651894 0.259980564182948 no 938 0.261002825194908 1320 5605015
SGTC_148 3253-0744 288.01 µM 0.639134042941642 0.260329108435485 no 939 0.261367867636698 1250 6893655
SGTC_2393 9031399 185.94 µM 0.638772301134167 0.260441455730069 no 940 0.261485534990023 1323 1526623 YDL150W RPC53
SGTC_2654 protoveratrine a 100 µM 0.638546301233281 0.26051165790359 no 941 0.261559062025982 1266 5702278 A heart drug and vasodilator.
SGTC_780 0109-0199 192 µM 0.637911704879321 0.260708834154897 no 942 0.261765578969588 1320 610414
SGTC_1865 st057639 52.2 µM 0.636308872106233 0.261207194128893 no 943 0.262287561681974 1287 688818
SGTC_2244 6635614 200 µM 0.63610639111521 0.261270185237263 no 944 0.262353540081013 1247 836499
SGTC_2157 5649910 96.377 µM 0.634364261452786 0.261812477768742 no 945 0.262921563710581 1258 2858091
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.633609380414365 0.262047637342595 no 946 0.263167888754342 1281 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2768 sulfasalazine 50.2 µM 0.631785452098184 0.262616271644228 no 947 0.263763540539316 1374 5384001 An antioxidant and salicylic acid derivative.
SGTC_2458 5808907 16.39 µM 0.631415643986517 0.262731641262678 no 948 0.263884394888069 1333 2731747
SGTC_2116 5511452 16.8835 µM 0.63141519650471 0.262731780879984 no 949 0.263884541143502 1307 870744
SGTC_2185 6113692 200 µM 0.630786465956353 0.262927986484572 no 950 0.264090076919498 1306 874150
SGTC_517 1365-0151 113 µM 0.630269583586161 0.263089344131718 no 951 0.264259109924191 1330 768657
SGTC_1363 1636-0063 10.4 µM 0.629187565814607 0.263427286564011 no 952 0.264613134127759 1319 6072185
SGTC_358 0075-0058 9.45 µM 0.628621544837625 0.263604157949526 no 953 0.264798425973794 1327 1069125
SGTC_2607 solasodine 47.35 µM 0.626616025678967 0.264231333960502 no 954 0.265455480451309 1311 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2586 curcumin 80 µM 0.625369010237533 0.264621689684871 no 955 0.265864448257548 1337 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1273 0849-0096 14.1 µM 0.622744892187735 0.265444079595998 no 956 0.266726088550472 1304 5286025
SGTC_907 3448-6986 75.5 µM 0.622461169170327 0.265533075076865 no 957 0.266819334691004 1363 590582
SGTC_3225 9130819 49.47 µM 0.620761549563713 0.26606651196966 no 958 0.26737826276515 1341 4547121
SGTC_2985 9022375 71.43 µM 0.620067187170621 0.266284598267553 no 959 0.267606776990708 1335 4939335
SGTC_359 0081-0058 15.9 µM 0.619883651357639 0.266342258562834 no 960 0.267667194957264 1443 3494159
SGTC_2468 5987765 72.9 µM 0.617456460481621 0.267105387687684 no 961 0.268466845528077 1380 26772094
SGTC_880 0833-0487 87.2 µM 0.617234484090657 0.267175233977904 no 962 0.268540036697592 1282 76075
SGTC_2001 4023502 57.655 µM 0.616995535602986 0.267250430948842 no 963 0.268618835200147 1346 108941 YCR052W RSC6
SGTC_2 0422-0095 29 µM 0.616885496234983 0.267285063874984 no 964 0.26865512700155 1204 6790840
SGTC_1628 st004252 77.7 µM 0.615051526586801 0.26786260626959 no 965 0.269260346306253 1357 692968
SGTC_1114 scopoletin 1.73284 µM 0.611587354813675 0.268955234179618 no 966 0.270405403245361 1357 5280460 A coumarin with genotoxic properties.
SGTC_2206 7254556 146.969 µM 0.60932253570642 0.269670784129518 no 967 0.271155336255706 1314 4398905
SGTC_133 0724-0033 378.92 µM 0.608406019772641 0.269960620180022 no 968 0.271459109963819 1221 280309
SGTC_2147 5545932 89.7195 µM 0.607061278556592 0.270386158808892 no 969 0.271905123006028 1318 797404
SGTC_3356 9151811 4.48 µM 0.606382601553119 0.27060105098788 no 970 0.272130359518877 1312 1859254 YPR165W RHO1
SGTC_2367 9070478 135.38 µM 0.606357523040335 0.270608993330446 no 971 0.272138684248484 1338 572802
SGTC_1819 st053448 58.6 µM 0.605184749871953 0.27098053952895 no 972 0.272528123757187 1321 2857616
SGTC_2021 4019055 173 µM 0.603762496608139 0.271431464711853 no 973 0.273000778377029 1347 44827708 YER133W GLC7
SGTC_62 0180-0423 3.232 µM 0.603423409933996 0.271539027252483 no 974 0.273113526348605 1298 30102 YGL099W LSG1
SGTC_198 3454-2873 16.191 µM 0.600809383061701 0.272368941265216 no 975 0.273983476908313 1312 710957
SGTC_622 1348-1566 26.3 µM 0.600701011335562 0.272403374831932 no 976 0.274019572664057 1392 7340407
SGTC_2085 5307070 144.047 µM 0.600598849676031 0.272435837218534 no 977 0.274053602162612 1295 2840351
SGTC_954 1189-0853 2.85 µM 0.600145709789828 0.272579847877083 no 978 0.274204565785773 1322 2828194
SGTC_1054 3429-0080 167 µM 0.596708627045638 0.273673402868159 no 979 0.275350965886053 1382 1162877
SGTC_2693 st077581 40.7 µM 0.596027210678271 0.273890462347991 no 980 0.27557852445067 1352 25238761
SGTC_1603 st002045 67.8 µM 0.595918466586191 0.273925109741666 no 981 0.275614848026308 1330 5887985
SGTC_1720 st037298 9.481 µM 0.59401784501693 0.274531024067289 no 982 0.276250088781914 1352 597396
SGTC_171 k064-0041 9.68 µM 0.593467948231449 0.27470645330986 no 983 0.276434013538587 1301 53325
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.59316964738296 0.27480164100256 no 984 0.276533811764068 1321 689007
SGTC_191 3914-0123 66.505 µM 0.589918017227677 0.275840288354214 no 985 0.277622807125501 1268 3144412
SGTC_2425 5628681 7.85 µM 0.587375396104792 0.27665380308379 no 986 0.278475807156815 1368 5714958
SGTC_202 3594-0513 34.79 µM 0.587244987587348 0.276695559125909 no 987 0.278519591084438 1340 708429
SGTC_925 2064-1272 59.6 µM 0.586401773166101 0.276965625950981 no 988 0.278802776507464 1345 6815817
SGTC_2398 5228213 48.84 µM 0.584539037994074 0.277562684473399 no 989 0.279428854394168 1401 80771 YMR134W ERG29
SGTC_2913 7966556 36.57 µM 0.583613238180152 0.277859662896686 no 990 0.279740275801764 1379 2976516
SGTC_311 1315-0136 58 µM 0.582957420157813 0.278070130274355 no 991 0.279960982334489 1421 6759207
SGTC_29 0299-0004 12.984 µM 0.582556142419468 0.278198948048147 no 992 0.280096068458569 1265 16871 A napthoquinone isolated from Swertia calycina.
SGTC_832 4083-0019 164 µM 0.581630071093112 0.278496345554171 no 993 0.28040794160048 1472 1990758
SGTC_1213 1315-0166 115 µM 0.581239771567761 0.278621732282649 no 994 0.280539433156501 1319 768401
SGTC_2348 9022543 33.42 µM 0.581142695911535 0.27865292285343 no 995 0.280572142490385 1393 3162678 YDL140C RPO21
SGTC_1231 0242-0792 125 µM 0.5791737200683 0.279285924785814 no 996 0.281235980658133 1351 3707635
SGTC_2806 7952793 58.44 µM 0.57795797338867 0.279677121251998 no 997 0.281646246737994 1413 2972490
SGTC_1425 4048-4433 7.33 µM 0.577761726183493 0.279740293547228 no 998 0.281712499395552 1409 23734946
SGTC_3187 9109394 49.47 µM 0.573954288421047 0.28096728222173 no 999 0.282999367319816 1299 17098090
SGTC_2079 5212404 121 µM 0.572243168378421 0.281519555287356 no 1000 0.283578622866784 1424 758462
SGTC_2686 alizarin 95.37 µM 0.571464508097785 0.281771045275066 no 1001 0.283842406157526 1347 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1212 0520-0165 585 µM 0.570743916228412 0.282003876887888 no 1002 0.28408662246943 1575 5403258
SGTC_2822 7994718 71.43 µM 0.569653920300781 0.282356243239436 no 1003 0.284456224660988 1386 1018011
SGTC_1904 st060225 78 µM 0.567580348117151 0.283027157470671 no 1004 0.285159977148743 1350 66595
SGTC_1853 st056710 91.2 µM 0.567139330565903 0.28316994943598 no 1005 0.285309761640747 1543 269167
SGTC_3103 9120822 49.47 µM 0.566679468594042 0.283318879618646 no 1006 0.285465986239971 1442 17141819
SGTC_1887 st057648 70.8 µM 0.56638446046304 0.283414440265966 no 1007 0.285566228028169 1441 688672
SGTC_794 k038-0031 316 µM 0.566380995217714 0.283415562838994 no 1008 0.285567405594881 1388 6624242
SGTC_3329 9141233 27.5565 µM 0.565902002493208 0.283570753979826 no 1009 0.285730200111339 1466 4909101 YNL103W MET4
SGTC_1756 st041558 35.5 µM 0.565349686358451 0.283749752049874 no 1010 0.285917969724691 1505 3955792
SGTC_1964 st076914 61 µM 0.564155132065628 0.284137075631665 no 1011 0.28632428004465 1390 24208661
SGTC_3201 9113999 49.47 µM 0.56245945088065 0.284687318953037 no 1012 0.286901511689884 1470 16649224
SGTC_2397 5161689 200 µM 0.561361542269666 0.285043857995705 no 1013 0.287275547714657 1472 2259942
SGTC_659 k018-0002 107 µM 0.561179210647232 0.285103089672162 no 1014 0.287337686874187 1386 6797879 YHR007C ERG11
SGTC_493 zm226600 134 µM 0.560480670642351 0.285330069459503 no 1015 0.287575810218136 1419 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2781 5567276 71.43 µM 0.559475270691564 0.28565690966693 no 1016 0.287918701857276 1434 2853274
SGTC_2981 9013952 38.96 µM 0.556812400523775 0.286523427848083 no 1017 0.288827805242908 1299 2996344
SGTC_3293 9120939 62.045 µM 0.556703133281822 0.286559010857442 no 1018 0.288865137901295 1431 934087
SGTC_2932 9016711 44.54 µM 0.554850570406148 0.287162619013891 no 1019 0.289498436930764 1467 7117328
SGTC_266 formosanin C 406 nM 0.554238191494754 0.287362278616186 no 1020 0.289707922100487 1412 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_747 3448-8087 38.7 µM 0.55242770762777 0.287952951314748 no 1021 0.290327675783637 1399 5168703
SGTC_211 3455-0679 143.504 µM 0.552057029087583 0.288073956325401 no 1022 0.290454640708308 1412 748649
SGTC_2663 amphotericin b 100 µM 0.550244062064527 0.288666130181687 no 1023 0.291075992821324 1385 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_660 4031-1742 102 µM 0.549726524289463 0.288835279942544 no 1024 0.291253480655271 1372 6738706
SGTC_1631 benzylvanillin 81.9 µM 0.547600692556953 0.289530566342417 no 1025 0.291983056890493 1452 75506
SGTC_281 1672-3440 14.9 µM 0.546223874152204 0.289981295201344 no 1026 0.29245602856464 1432 6833000
SGTC_303 1348-1668 34.2 µM 0.545362464765465 0.290263461879162 no 1027 0.292752125303916 1427 5380509
SGTC_31 0508-1974 57.237 µM 0.544312280254129 0.290607638351972 no 1028 0.29311329889556 1414 6810525
SGTC_896 0964-0007 44.5 µM 0.544234429595785 0.290633159910992 no 1029 0.293140081084613 1406 6756758
SGTC_1867 st057372 64 µM 0.543639333025509 0.29082828335202 no 1030 0.293344843731102 1405 688837
SGTC_1715 st032160 10.2275 µM 0.542439073979786 0.291222016906826 no 1031 0.293758034055257 1427 5289825
SGTC_335 4077-0256 27.6 µM 0.541021869772024 0.291687237387225 no 1032 0.294246254384175 1435 3121989
SGTC_3104 9120930 49.47 µM 0.539230463021633 0.292275791140589 no 1033 0.294863921533186 1422 17014836
SGTC_565 1418-0001 44.5 µM 0.535583355499735 0.293475725905344 no 1034 0.296123267324965 1471 2862145
SGTC_484 loperamide 105 µM 0.535217918554436 0.293596083972445 no 1035 0.296249588578046 1410 3955 An opioid-receptor agonist.
SGTC_2308 7584454 197.62 µM 0.532570458040968 0.294468717015252 no 1036 0.297165478256052 1525 893577
SGTC_344 k064-0035 6.43 µM 0.532173811610551 0.294599559229047 no 1037 0.297302809616858 1396 5088750
SGTC_1940 st075990 51.1 µM 0.53208958489746 0.294627346643797 no 1038 0.297331975263242 1518 1084979
SGTC_2830 7992007 71.43 µM 0.531460173800019 0.294835035269049 no 1039 0.297549966270332 1449 1952075
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.531034141568587 0.294975652662515 no 1040 0.297697560186677 1466 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_714 4296-0578 26.1 µM 0.530158944077313 0.295264619697302 no 1041 0.298000866934796 1448 1589775
SGTC_3061 glucosamine 200 µM 0.527459726398929 0.296156649406226 no 1042 0.298937188390273 1434 91431 and experimental redox chemotherapeutic
SGTC_1667 st014849 34.6 µM 0.526453697925 0.296489434816075 no 1043 0.299286507340535 1467 5348460
SGTC_225 nsc-122657 1.016 µM 0.525555822710362 0.296786588712765 no 1044 0.299598428991636 1441 275685
SGTC_808 0711-0032 135 µM 0.525512556636127 0.29680091116337 no 1045 0.299613463335838 1492 4252555
SGTC_1809 st050081 57.6 µM 0.525317971421895 0.29686532898665 no 1046 0.299681083150228 1519 5036894
SGTC_1352 1496-0991 99 µM 0.525051435157766 0.296953576731631 no 1047 0.29977371771005 1441 3000039
SGTC_707 0865-0008 204 µM 0.521777052203106 0.298038673221906 no 1048 0.300912784529493 1521 723043
SGTC_105 0111-0055 734.78 µM 0.520069255375533 0.298605335381426 no 1049 0.301507653001723 1429 5179370
SGTC_2111 5486399 200 µM 0.518911471821741 0.298989776710778 no 1050 0.301911238773233 1437 689674
SGTC_1771 st048882 4.1505 µM 0.518392397434328 0.299162207994732 no 1051 0.302092258994582 1397 4580403
SGTC_1993 st073995 70.8 µM 0.516932683131618 0.299647352129216 no 1052 0.302601575764878 1479 3098394
SGTC_3228 9131799 49.47 µM 0.516264480625656 0.299869551796539 no 1053 0.302834850221551 1487 17015818
SGTC_3258 9138477 49.47 µM 0.516237741819773 0.299878444895114 no 1054 0.30284418661256 1497 4970355
SGTC_73 0327-0325 16.231 µM 0.514467438883197 0.300467497942718 no 1055 0.303462609919852 1473 53298
SGTC_886 0866-0150 153 µM 0.51137727335539 0.301496974215037 no 1056 0.3045434527772 1567 271463
SGTC_2715 st079500 56.4 µM 0.510734961061496 0.301711157070507 no 1057 0.304768328273918 1415 28246688
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.509390293684173 0.302159765777827 no 1058 0.305239339264108 1442 688669
SGTC_1020 4335-0961 93.3 µM 0.508686320431835 0.302394745087428 no 1059 0.305486056235317 1399 669075
SGTC_819 1013-0258 27.7 µM 0.505816071169542 0.303353652986448 no 1060 0.306492887664809 1467 5753198
SGTC_3170 9103054 49.47 µM 0.504148771767185 0.303911296297045 no 1061 0.307078418138879 1405 16432970
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.503352284998504 0.304177849730953 no 1062 0.307358306179151 1518 688801
SGTC_1306 1185-0270 9.02 µM 0.502625176917526 0.304421275692175 no 1063 0.307613912321211 1528 1548076
SGTC_2260 7964312 200 µM 0.501557680380701 0.304778816116048 no 1064 0.307989347199997 1569 231951
SGTC_1033 k072-0102 21.3 µM 0.499090989981411 0.30560570660474 no 1065 0.30885764232997 1592 5965931
SGTC_185 k048-0037 25.491 µM 0.497898245144121 0.306005897925503 no 1066 0.309277882128134 1516 6827589
SGTC_404 fumagillin 50 µM 0.496711021397193 0.306404466894698 no 1067 0.309696424590546 1502 12015870 A methionine aminopeptidase binder.
SGTC_2177 5811945 192 µM 0.495117178153167 0.306939904465034 no 1068 0.310258704341225 1561 5343475
SGTC_2284 7945075 39.21 µM 0.493978890520327 0.307322554463815 no 1069 0.310660543892419 1599 1245402
SGTC_3087 9117406 49.47 µM 0.492981762932133 0.307657924149917 no 1070 0.311012736692413 1475 42546093
SGTC_1100 amiodarone 5.07 µM 0.488880483292619 0.309039019713521 no 1071 0.312463156857162 1536 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1443 4112-3303 14 µM 0.488590086938609 0.309136912670089 no 1072 0.312565966289438 1497 704433
SGTC_2170 morpholine 200 µM 0.48772148287081 0.309429801013556 no 1073 0.312873566465788 1573 121171 Reacts with secondary amines.
SGTC_1780 st038448 24.544 µM 0.486891798973906 0.309709678789878 no 1074 0.313167505489923 1596 728868 YDL195W SEC31
SGTC_1560 lithocholic acid 53.1 µM 0.485959909683528 0.310024165164425 no 1075 0.313497795274357 1507 9903 A bile acid which acts as a detergent.
SGTC_2582 agaric acid 100 µM 0.485822788548825 0.310070451422673 no 1076 0.313546407788708 1387 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2951 9072950 58.06 µM 0.48567875008255 0.310119075919031 no 1077 0.313597476139753 1486 16488155
SGTC_231 b-estradiol 524 µM 0.483346776006515 0.310906765141427 no 1078 0.31442476623638 1440 450 A steroid.
SGTC_1901 st060216 58.6 µM 0.482787033302426 0.311095963033864 no 1079 0.314623479293626 1481 688792
SGTC_1777 st045864 34.765 µM 0.482323457760881 0.311252693393831 no 1080 0.314788092913455 1505 4691462
SGTC_2243 6634756 200 µM 0.479073819280062 0.312352323960832 no 1081 0.315943057048298 1608 885676
SGTC_1035 k081-0041 55.2 µM 0.478571099346686 0.312522586797462 no 1082 0.316121891264006 1525 731709
SGTC_640 3381-0960 37.1 µM 0.476336055391156 0.313280042962086 no 1083 0.316917491243008 1597 1745025
SGTC_579 4491-1009 110 µM 0.473762956331209 0.314153042247647 no 1084 0.317834476640581 1645 1271041
SGTC_290 2043-6722 48.1 µM 0.473362763913449 0.314288912907897 no 1085 0.317977195409967 1535 773758 YLR208W SEC13
SGTC_1529 apigenin 74 µM 0.468962039914362 0.315784674036424 no 1086 0.319548384802086 1612 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1630 st005209 31.3 µM 0.468205533946947 0.316042107748762 no 1087 0.319818807555234 1562 3367314
SGTC_786 4544-0069 423 µM 0.464140438142899 0.317426956889471 no 1088 0.321273565625664 1592 748821 YLR208W SEC13
SGTC_1746 st038117 42 µM 0.460621655881598 0.318627762175815 no 1089 0.322535035901328 1556 2898218
SGTC_2305 7443522 69.23 µM 0.460471670480892 0.318678988048817 no 1090 0.322588850663121 1598 5415886
SGTC_2232 chlorophetanol 41.5365 µM 0.460334439141042 0.318725860947658 no 1091 0.322638092524044 1625 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3038 9091290 49.47 µM 0.460118658001384 0.318799569274517 no 1092 0.322715526207983 1583 25236843
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.459213932557489 0.319108690968615 no 1093 0.323040273205229 1537 1241132 A phosphatase inhibitor.
SGTC_97 0535-0701 19.132 µM 0.457357010125665 0.319743548170053 no 1094 0.323707229391803 1468 2832013 YGL099W LSG1
SGTC_870 0573-2213 57.6 µM 0.455973888773599 0.320216762598338 no 1095 0.324204377412785 1505 3916321
SGTC_1908 st060353 56.5 µM 0.455830113443026 0.32026596999136 no 1096 0.324256073909925 1718 4227716
SGTC_1654 st012436 41.8 µM 0.455799663163472 0.32027639206577 no 1097 0.324267023182641 1558 4323132
SGTC_3256 9138902 49.47 µM 0.455373351676214 0.320422318583233 no 1098 0.324420331677516 1595 17228773
SGTC_1229 0139-0193 12.2 µM 0.455216807260303 0.32047591074365 no 1099 0.32447663505019 1641 3090752
SGTC_1998 st075797 76.8 µM 0.454786407353322 0.320623275188489 no 1100 0.324631455030109 1595 24208315
SGTC_2534 helenine 20.12 µM 0.449606013948854 0.322399200787623 no 1101 0.326497275470891 1565 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1309 pyrazolanthrone 13.4 µM 0.447198854148477 0.323225799962084 no 1102 0.327365744328973 1651 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3275 9138069 49.47 µM 0.446984514137078 0.323299444997623 no 1103 0.32744312055458 1599 17617007
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.446900609100909 0.323328275795878 no 1104 0.327473412088879 1639 688798
SGTC_1283 0922-0125 16.4 µM 0.446265261550293 0.323546623421242 no 1105 0.327702823160573 1657 3360884
SGTC_898 1000-0849 28.3 µM 0.445480764148606 0.323816312681884 no 1106 0.327986178955692 1573 6751807
SGTC_3145 9085516 49.47 µM 0.444049240615827 0.324308670646804 no 1107 0.328503491904528 1533 25236195
SGTC_3072 9116419 49.47 µM 0.443975689939926 0.324333975962471 no 1108 0.328530079973191 1502 17170162
SGTC_2413 inermin 26.06 µM 0.44330962359018 0.324563174882127 no 1109 0.328770897943533 1695 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3037 9091026 49.47 µM 0.443033023343893 0.324658374841473 no 1110 0.328870924364714 1568 25236398 YIL048W NEO1
SGTC_2734 clemastine 41.6 µM 0.441920462717701 0.325041410358588 no 1111 0.329273381300487 1592 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1557 sumaresinolic acid 42.3 µM 0.439330479114743 0.325933813287042 no 1112 0.330211046225625 1501 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3338 9144300 39.5675 µM 0.43815528581306 0.326339066563967 no 1113 0.330636859823565 1623 4901274
SGTC_2920 7982904 15.77 µM 0.437173054412554 0.326677936300876 no 1114 0.330992924857604 1534 6456808
SGTC_1843 st055809 45.5 µM 0.436973144890962 0.326746922593816 no 1115 0.331065412050053 1552 16413835
SGTC_524 r073-0010 27.8 µM 0.436032371903933 0.327071651162998 no 1116 0.331406621315891 1516 2772106
SGTC_1251 0490-5699 265 µM 0.434203014121461 0.327703469162139 no 1117 0.332070512260586 1702 3883818
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.432338942247264 0.328347784424013 no 1118 0.332747543917598 1732 551469
SGTC_1553 gossypol 38.6 µM 0.432325258389614 0.328352516131941 no 1119 0.332752515920755 1565 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2823 7987624 58.44 µM 0.430893660365591 0.32884769693607 no 1120 0.333272846653147 1583 2239440
SGTC_2133 5320837 200 µM 0.430626904073122 0.328939999518392 no 1121 0.333369837802767 1626 2841355
SGTC_3200 9114385 49.47 µM 0.427175602364979 0.330135152311178 no 1122 0.33462571511994 1535 17018030 YLR208W SEC13
SGTC_1057 3448-5381 134 µM 0.42655023532209 0.330351897012365 no 1123 0.334853475525523 1683 5497911
SGTC_627 1391-0720 175 µM 0.42595946805101 0.330556702142532 no 1124 0.335068690413317 1576 997839
SGTC_407 eburnamonine 100 µM 0.425114475501487 0.330849729401523 no 1125 0.335376612995689 1540 3195
SGTC_313 3474-0040 5.03 µM 0.423489342092223 0.331413585902597 no 1126 0.3359691364817 1551 1043375 YIL048W NEO1
SGTC_1487 3970-0795 2.82 µM 0.421778189865698 0.33200770076464 no 1127 0.336593463285791 1625 3765103
SGTC_2320 7373003 200 µM 0.421259020088629 0.332188040992215 no 1128 0.336782975493582 1521 5415828
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.419389904578138 0.332837623663182 no 1129 0.337465600472126 1666 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1385 3091-4834 14.1 µM 0.419146766339111 0.332922159603645 no 1130 0.33755443706639 1657 4072814
SGTC_1844 rapamycin 4 nM 0.418655233930194 0.333093084837804 no 1131 0.33773405828826 1598 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1596 piperlongumine 63 µM 0.41861245091986 0.333107963821477 no 1132 0.337749694279515 1693 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2245 6637752 200 µM 0.41799088446498 0.333324160494788 no 1133 0.33797689097512 1736 681890
SGTC_1570 verbenone 133 µM 0.41766391859889 0.333437909801485 no 1134 0.338096428145808 1718 29025 A natural terpanoid with antifungal properties.
SGTC_374 0880-0231 82.3 µM 0.417202416638373 0.333598489410134 no 1135 0.338265178855753 1630 6833587
SGTC_1356 1502-0781 85.8 µM 0.417098025674572 0.333634816475774 no 1136 0.338303354488696 1608 567702
SGTC_834 0312-0008 75.7 µM 0.414116454485815 0.334673032319157 no 1137 0.339394411408344 1611 6385573 YIL048W NEO1
SGTC_392 N-ethylmaleimide 8.33 µM 0.413600227274645 0.334852917023058 no 1138 0.339583453386062 1597 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2028 5153890 36.43 µM 0.413468607613371 0.334898787318592 no 1139 0.33963165885695 1598 2830968 YPR165W RHO1
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.413142462202246 0.335012461697666 no 1140 0.339751120346809 1579 6708630 An antioxidant.
SGTC_3130 9127414 49.47 µM 0.413014808225249 0.335056958197216 no 1141 0.339797882200827 1597 1494646
SGTC_314 1671-0008 2.74 µM 0.410856990255168 0.335809461271871 no 1142 0.340588700715979 1586 3913060
SGTC_2858 9025781 8.96 µM 0.410835033270202 0.335817121795421 no 1143 0.340596751339582 1644 4894980 YPL153C RAD53
SGTC_236 1509-0011 5.31 µM 0.410632993193354 0.335887614309082 no 1144 0.340670833616703 1633 3107280
SGTC_2046 4110841 106 µM 0.409683809686147 0.336218865113646 no 1145 0.34101895409692 1652 44119630 YMR134W ERG29
SGTC_978 1416-0512 87.4 µM 0.407146283198187 0.337105047807882 no 1146 0.34195027590873 1642 6814003
SGTC_1014 4130-3005 69.3 µM 0.406677545840964 0.337268844525736 no 1147 0.34212241716751 1596 743608
SGTC_2374 9071832 200 µM 0.405782682817938 0.337581633270969 no 1148 0.342451141875186 1588 17381698
SGTC_429 1112-0049 25.5 µM 0.405536942921826 0.337667548386499 no 1149 0.342541434444349 1548 2836170
SGTC_256 clotrimazole 625 nM 0.405486487088834 0.337685189706016 no 1150 0.342559974618449 1624 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3239 9133757 49.47 µM 0.405206055667077 0.337783245925121 no 1151 0.342663027046976 1666 17036923
SGTC_283 0987-0079 11.7 µM 0.405176799905486 0.33779347618839 no 1152 0.342673778575707 1698 411556
SGTC_2256 7954252 200 µM 0.403324129188776 0.338441568760672 no 1153 0.343354896623429 1600 2972920
SGTC_3165 9101544 49.47 µM 0.402338431929947 0.338786576030118 no 1154 0.343717487153163 1674 5002184
SGTC_918 glabranin 770.725 nM 0.402014918767395 0.33889983948292 no 1155 0.343836523421796 1670 124049 Also referred to as licorice root.
SGTC_989 1501-0895 10.3 µM 0.401097988031482 0.339220940288706 no 1156 0.344173991047148 1736 2830112
SGTC_853 0419-0306 21 µM 0.400976682069407 0.33926342928681 no 1157 0.344218645854119 1570 762713
SGTC_3065 9113888 49.47 µM 0.400508596797593 0.339427401424818 no 1158 0.344390976434589 1697 16648368
SGTC_2379 9035213 200 µM 0.400141901279071 0.339555877569407 no 1159 0.344526001868966 1767 646551
SGTC_2867 9039098 71.43 µM 0.399046716155854 0.339939699689766 no 1160 0.344929391253134 1606 6463460
SGTC_36 0335-0881 14.2 µM 0.398013781661156 0.340301857360474 no 1161 0.345310013461532 1642 23828853
SGTC_1182 1222-0449 220 µM 0.393222494283597 0.341983655344555 no 1162 0.347077578550114 1642 658318
SGTC_3263 9137018 49.47 µM 0.392453376260101 0.342253918129743 no 1163 0.347361627067255 1540 43844957
SGTC_649 1123-0311 367 µM 0.392130832577402 0.342367281822232 no 1164 0.347480773527275 1695 693629 YIL048W NEO1
SGTC_571 k831-0106 44.2 µM 0.390691742148908 0.342873248596209 no 1165 0.348012551757475 1741 4783639
SGTC_2032 5185112 25.99 µM 0.389221382448368 0.343390500480912 no 1166 0.348556193611927 1654 5718189
SGTC_3246 9135460 32.98 µM 0.388103702230216 0.343783881064369 no 1167 0.34896964614682 1697 41446951
SGTC_798 1287-0182 476 µM 0.387017284869767 0.344166420497902 no 1168 0.349371705850172 1775 1649755
SGTC_2300 7976697 71.57 µM 0.386683111050144 0.344284118851715 no 1169 0.349495410417415 1585 2236109
SGTC_1651 st011928 86.1 µM 0.386199843607357 0.344454355697212 no 1170 0.349674334780332 1651 720198
SGTC_3088 9117578 49.47 µM 0.38443816075533 0.345075196549826 no 1171 0.350326860651089 1667 678341
SGTC_3161 9100388 49.47 µM 0.384205331269589 0.345157280060345 no 1172 0.350413133611439 1710 25236368
SGTC_3042 9091578 49.47 µM 0.383516640624236 0.345400119028925 no 1173 0.350668367159586 1666 25236497
SGTC_3015 9080845 49.47 µM 0.383177614427921 0.345519686324128 no 1174 0.350794037399446 1764 5296973
SGTC_2831 7999036 19.48 µM 0.381348442014628 0.346165062034714 no 1175 0.351472356445567 1822 2988270
SGTC_308 4092-1169 104 µM 0.379364719438238 0.34686547200779 no 1176 0.352208522867496 1661 2268590 YDL196W YDL196W
SGTC_3244 9134489 49.47 µM 0.379176449379284 0.346931973377518 no 1177 0.352278419382653 1607 16584271
SGTC_1429 4049-0205 9.46 µM 0.379117303168809 0.346952866170022 no 1178 0.352300378837945 1675 22774478
SGTC_1498 4478-3555 97.6 µM 0.378017699679498 0.347341374507756 no 1179 0.352708722723687 1724 3437919
SGTC_384 k007-0144 5.16 µM 0.377402752977069 0.347558715466483 no 1180 0.352937160657065 1670 6824886
SGTC_1098 clofazimine 15.1 µM 0.376143385993424 0.348003970605901 no 1181 0.353405150651801 1724 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_677 0929-0063 136 µM 0.376016286957765 0.348048918726456 no 1182 0.353452393913556 1630 1539583
SGTC_1262 0737-0114 49.6 µM 0.375400837839866 0.348266600300058 no 1183 0.353681190940571 1782 765919
SGTC_1723 st034307 2.5525 µM 0.375041056637931 0.348393876446463 no 1184 0.353814966324856 1633 867466
SGTC_3160 9100216 49.47 µM 0.373986460676852 0.348767048480599 no 1185 0.354207194655566 1672 17191039
SGTC_2390 9097792 176.6 µM 0.372549064064318 0.349275911343397 no 1186 0.354742044386059 1597 4497149
SGTC_2813 7971799 71.43 µM 0.372260799063966 0.349377994719978 no 1187 0.354849341198741 1695 2234054
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.370421184230868 0.350029714477976 no 1188 0.35553434595251 1727 5393153
SGTC_1237 0330-0133 46.1 µM 0.369164486454052 0.350475178631932 no 1189 0.3560025624484 1671 X1237 YHR072W ERG7
SGTC_842 0271-0008 11.1 µM 0.367201455172806 0.351171429709041 no 1190 0.356734376978428 1733 1221709
SGTC_2496 diffractaic acid 79.83 µM 0.365963623825533 0.351610722847344 no 1191 0.357196109721904 1802 94870 An apoptosis inducer which activates caspases.
SGTC_229 benomyl 22.8748 µM 0.364783269758995 0.352029802573248 no 1192 0.357636597309735 1660 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1764 st044502 93.5 µM 0.363141143168348 0.352613131666706 no 1193 0.358249725790808 1658 8407
SGTC_63 0099-0242 26.702 µM 0.362433950783137 0.352864452996927 no 1194 0.358513886268979 1758 3898502 YLR359W ADE13
SGTC_355 1311-2252 105 µM 0.362428281477571 0.352866468008728 no 1195 0.358516004221743 1639 5338538
SGTC_2453 5731132 22.18 µM 0.36238604887828 0.352881478651794 no 1196 0.358531781714383 1822 1362040
SGTC_3003 9075612 71.4286 µM 0.362092259450635 0.352985905940211 no 1197 0.358641543906916 1690 6501993
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.36092618102697 0.35340049700782 no 1198 0.359077315650665 1834 5024745
SGTC_1983 st071813 46.9 µM 0.359557134506443 0.353887474030839 no 1199 0.359589172082397 1698 11838595
SGTC_1550 gossypolone 36.6 µM 0.357699784654583 0.354548525293717 no 1200 0.360283997138057 1708 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3251 9135047 49.47 µM 0.356642985951313 0.354924847383649 no 1201 0.360679546367393 1806 17682963
SGTC_480 am 92016 50 µM 0.356113349773378 0.355113502141868 no 1202 0.360877840029013 1644 2129 K+ channel blocker.
SGTC_1649 st011737 51.3 µM 0.355680169869585 0.355267825884957 no 1203 0.361040048656722 1683 1761035
SGTC_1714 st033236 13.627 µM 0.355155573176984 0.355454749357557 no 1204 0.361236522692253 1796 2916566
SGTC_914 3820-6779 408 µM 0.354646107287864 0.355636314731813 no 1205 0.361427364920171 1639 2893481
SGTC_674 0498-0004 451 µM 0.353719796572264 0.355966520745919 no 1206 0.361774442517432 1670 4231473
SGTC_3344 9148862 3.898 µM 0.35147053153729 0.356768775448901 no 1207 0.362617688237205 1790 4905352
SGTC_2704 st078022 71.1 µM 0.351348761679219 0.356812225730821 no 1208 0.362663358617325 1832 54697681
SGTC_2976 9009005 19.48 µM 0.350744858216049 0.357027739799158 no 1209 0.36288988442465 1854 2993148
SGTC_3010 9080089 71.4286 µM 0.349585610149382 0.357441566627169 no 1210 0.363324855888059 1783 17027233
SGTC_1131 3454-3128 32.3 µM 0.347725667740762 0.358105876585175 no 1211 0.364023109072915 1800 710982
SGTC_1919 st067113 52.3 µM 0.347427755941978 0.358212320822944 no 1212 0.364134992124524 1668 1268243
SGTC_91 0417-1751 58.384 µM 0.345246650343078 0.358991967668398 no 1213 0.364954475200149 1725 6795624
SGTC_1621 st003705 32.4 µM 0.344817501768183 0.35914543821974 no 1214 0.365115787313515 1831 24207032
SGTC_2992 9074591 71.4286 µM 0.343381785948685 0.359659038804039 no 1215 0.365655630089384 1728 17741321
SGTC_1276 0871-0068 94.2 µM 0.34189825385495 0.360190011164757 no 1216 0.366213731880741 1784 3414906
SGTC_988 1497-1057 103 µM 0.341411414009257 0.360364315319894 no 1217 0.366396941811019 1866 3533044
SGTC_3028 9087778 49.47 µM 0.340591186270335 0.36065804857883 no 1218 0.366705682747124 1651 17217395
SGTC_1556 plumbagin 1.48 µM 0.340427661574011 0.360716618544098 no 1219 0.366767245200322 1724 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_214 4373-3496 70 µM 0.337113923073261 0.361904209059901 no 1220 0.368015511021938 1800 3779166
SGTC_699 0375-0592 111 µM 0.336985793979942 0.361950155263131 no 1221 0.368063804593597 1836 762578
SGTC_1426 4048-4480 71.7 µM 0.336365133589239 0.362172747921713 no 1222 0.368297769311565 1801 14224343
SGTC_2464 5717415 7.67 µM 0.336320150211808 0.362188882501536 no 1223 0.368314728186834 1640 5285744
SGTC_3309 9129340 25.759 µM 0.336106859681342 0.362265388606533 no 1224 0.368395142881887 1768 17158987
SGTC_894 0960-0238 55.9 µM 0.335814728240737 0.362370183427523 no 1225 0.368505291494325 1775 6741907 YDL195W SEC31
SGTC_235 0330-0087 5 mM 0.335185307692389 0.362596007291846 no 1226 0.368742652200888 1720 46494818 YHR062C RPP1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.33493371231157 0.362686288205368 no 1227 0.36883754531962 1829 16725076
SGTC_2065 5221596 34.26 µM 0.334043852208327 0.363005661262888 no 1228 0.369173234048273 1761 788581
SGTC_1673 st016611 27.3 µM 0.333742819862159 0.363113724121483 no 1229 0.369286817384211 1816 5226799
SGTC_2665 lovastatin 100 µM 0.332166604324331 0.363679722646933 no 1230 0.369881729671435 1735 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1012 4112-3522 18 µM 0.331660651917314 0.363861466746594 no 1231 0.370072757809445 1841 3112398
SGTC_2720 fluspirilene 36.88 µM 0.33019642479925 0.364387606945092 no 1232 0.370625774042862 1790 3396 An atypical antipsychotic.
SGTC_552 k242-0005 476 µM 0.329753451188224 0.364546830902543 no 1233 0.370793131155636 1726 4088318
SGTC_1491 4138-0063 26.5 µM 0.329013067116889 0.364813009264589 no 1234 0.371072905634947 1838 23883227
SGTC_1708 st033234 31.827 µM 0.327597124255585 0.365322241809345 no 1235 0.371608148285008 1815 674664
SGTC_3172 9105863 49.47 µM 0.326766322186845 0.365621143775821 no 1236 0.371922316664676 1768 2348785
SGTC_569 4130-2812 160 µM 0.325028274009603 0.366246714149692 no 1237 0.372579836449914 1845 743552
SGTC_210 3551-0445 56.827 µM 0.323818407356096 0.366682387815298 no 1238 0.373037759697801 1777 2865180 YOR207C RET1
SGTC_1735 st034310 56.75 µM 0.322843980391348 0.367033404465528 no 1239 0.37340670170538 1835 871153
SGTC_1062 mesoridazine 14.2 µM 0.321590550085931 0.367485089617504 no 1240 0.373881451891242 1738 4078 A neuroleptic.
SGTC_1106 tegaserod maleate 11.7 µM 0.320141798787286 0.368007388950869 no 1241 0.374430420427269 1776 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_426 0988-0037 14.6 µM 0.317269293992385 0.36904369651394 no 1242 0.375519637270166 1926 5383008
SGTC_2214 7179297 48.276 µM 0.315529468839799 0.369671833359175 no 1243 0.376179840009828 1820 769744
SGTC_1609 st001574 46.4 µM 0.315091459141489 0.369830024848881 no 1244 0.376346106550548 1718 3960012
SGTC_254 nsc-64875 3.808 µM 0.314547807744608 0.37002640051111 no 1245 0.376552506127053 1891 56993
SGTC_1459 k035-0031 35.7 µM 0.310099954491316 0.371634305608576 no 1246 0.378242473434978 1669 3877128 YMR208W ERG12
SGTC_1558 st069300 45.6 µM 0.310093143058978 0.371636769677234 no 1247 0.37824506324354 1875 24208000
SGTC_2774 tamoxifen 10.92 µM 0.308689972423117 0.372144485455158 no 1248 0.378778686202097 1770 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2836 9010338 19.48 µM 0.308380279301374 0.372256573146942 no 1249 0.378896493047339 1623 2994051
SGTC_1179 1021-1431 9.29 µM 0.307622271402592 0.37253096572106 no 1250 0.379184885679693 1788 2840958
SGTC_2675 theaflavin digallate 100 µM 0.30713392777958 0.37270777634648 no 1251 0.379370717135869 1790 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2546 rhodinyl acetate 100 µM 0.306809292358231 0.372825329312909 no 1252 0.379494267446955 1898 6708682
SGTC_2674 ligustilide 100 µM 0.306600820395603 0.372900824849194 no 1253 0.3795736145573 1780 5319022 A signalling regulator.
SGTC_2293 7624732 200 µM 0.305893461419547 0.373157022498295 no 1254 0.37984288226342 1699 894453
SGTC_2084 5306078 60.6385 µM 0.305842353777541 0.37317553529891 no 1255 0.379862339477677 1835 679340
SGTC_2492 derrusnin 100 µM 0.303388230490831 0.374064840060727 no 1256 0.38079700698988 1749 1715307 Part of coumarin class of compounds.
SGTC_146 3448-8650 53.125 µM 0.302916381554102 0.374235901764321 no 1257 0.380976793426471 1797 2891488 YIL048W NEO1
SGTC_2927 9011802 47.9 µM 0.302127913205202 0.374521804302075 no 1258 0.381277277238719 1705 43912568
SGTC_1976 st070609 63.5 µM 0.301767432038648 0.374652539556975 no 1259 0.381414679793885 1782 682556
SGTC_102 gallobenzophenone 83.616 µM 0.301567454916159 0.374725071225389 no 1260 0.381490910383031 1866 70837
SGTC_1040 k898-0338 155 µM 0.301172406611387 0.374868368201959 no 1261 0.381641514942654 1955 20969351
SGTC_1383 3049-0032 20.7 µM 0.300400997574594 0.375148233351646 no 1262 0.381935651424817 1899 712864
SGTC_1141 3253-0389 52.6 µM 0.300248997843415 0.37520338620803 no 1263 0.381993616615289 1871 5402031
SGTC_1620 st003704 16.5 µM 0.299775946728324 0.375375048361145 no 1264 0.382174031870071 1903 2834414
SGTC_1382 3002-2117 298 µM 0.299273048825026 0.375557568468019 no 1265 0.382365858341509 1891 1497314
SGTC_2815 7968870 71.43 µM 0.297771683421588 0.376102634643609 no 1266 0.382938714023849 1731 2977326 YHR190W ERG9
SGTC_2733 amorolfine 100 µM 0.296588241966711 0.376532453804766 no 1267 0.383390444363645 1905 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_873 0591-4978 488 µM 0.295902290841129 0.376781657461526 no 1268 0.383652350766692 1956 3305145
SGTC_1922 5578187 25 µM 0.295743081729779 0.376839504923489 no 1269 0.383713146793534 1887 1350412
SGTC_1462 k081-0014 26.5 µM 0.293658598873416 0.377597141111284 no 1270 0.384509396693921 1717 3270634
SGTC_772 k072-0172 35.3 µM 0.290838970715724 0.378622726122693 no 1271 0.385587239352454 1688 5861980
SGTC_3341 9147222 25.867 µM 0.29048613859231 0.378751122324651 no 1272 0.385722176820903 1825 1939759
SGTC_681 1642-0006 26.6 µM 0.288651202050771 0.379419074298459 no 1273 0.386424154430583 1795 4446530
SGTC_380 3970-0968 6 µM 0.288625570041511 0.379428407394365 no 1274 0.386433962910802 1784 2891601
SGTC_549 1661-1316 519 µM 0.287779521254235 0.379736509049766 no 1275 0.386757757105335 1912 2857282
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.285169222987645 0.38068756971452 no 1276 0.387757249150831 1803 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_349 k015-0014 24 µM 0.284943400505491 0.380769881994388 no 1277 0.387843752413145 1760 2196908
SGTC_2956 9076196 2.52 µM 0.284308597330197 0.381001296607733 no 1278 0.388086949084324 1888 16423868
SGTC_527 4476-4215 268 µM 0.284043100494089 0.381098094902683 no 1279 0.388188675441094 1817 4418754
SGTC_2058 5236698 133 µM 0.283224435595382 0.381396621235424 no 1280 0.388502399003913 1789 766665
SGTC_906 1165-0455 526 µM 0.283158309169612 0.381420737333861 no 1281 0.388527742730858 1757 3252859
SGTC_1230 0170-0365 3.77 µM 0.28310940934407 0.38143857124177 no 1282 0.388546484466779 1915 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2187 6125751 200 µM 0.282879221463457 0.381522524809039 no 1283 0.38863471158876 1833 874498
SGTC_1146 3579-1023 7 µM 0.280112105873997 0.382532175728481 no 1284 0.389695748600582 1931 X1146
SGTC_910 3454-3003 490 µM 0.279554044454726 0.382735895350987 no 1285 0.389909834472795 1935 820824
SGTC_3213 9129884 49.47 µM 0.279013177392191 0.382933369160637 no 1286 0.390117356047988 1703 17190742
SGTC_3204 9114183 49.47 µM 0.27877060982396 0.383021941922664 no 1287 0.390210435311299 1731 17027248
SGTC_2608 thymoquinone 42.66 µM 0.278183372863582 0.383236394916793 no 1288 0.390435798924155 1872 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2882 9058044 58.44 µM 0.277861689542669 0.383353885584843 no 1289 0.390559266772524 1720 18076804
SGTC_1635 st007035 42.4 µM 0.277660130531742 0.383427507871757 no 1290 0.390636634373458 1805 3716403
SGTC_143 4032-1194 15.74 µM 0.276101109751433 0.38399710433219 no 1291 0.39123520416718 1782 1806963
SGTC_2249 haloperidol 116.36 µM 0.275320281471283 0.384282478352999 no 1292 0.391535091996773 1853 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1726 st035556 14.5795 µM 0.273979620160179 0.384772604184201 no 1293 0.392050141689514 1914 5919439
SGTC_2731 amoxapine 43.43 µM 0.273946835066982 0.384784592237095 no 1294 0.392062739304108 1921 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3135 9127742 49.47 µM 0.271286453822463 0.38575774170928 no 1295 0.393085362118838 1783 3643468
SGTC_1783 st039459 87.517 µM 0.266369969899417 0.387558047614897 no 1296 0.394977145276431 1960 729761
SGTC_748 act1.228 77.9 µM 0.264804536855703 0.38813178389523 no 1297 0.395580020860538 1765 4421505 YNR035C ARC35
SGTC_440 fluspirilene 35.1 µM 0.264486747391282 0.388248284627227 no 1298 0.395702437696202 1908 3396 An atypical antipsychotic.
SGTC_1449 4112-4002 201 µM 0.264315435641277 0.388311091209629 no 1299 0.395768433587906 1784 2059539
SGTC_2372 9071633 200 µM 0.261863957930711 0.389210175008151 no 1300 0.396713163810813 1970 21321366
SGTC_996 3970-0799 1.8 µM 0.260333013883394 0.389771952821333 no 1301 0.397303454444227 1960 6615648 YGL040C HEM2
SGTC_1988 st071872 53.4 µM 0.259353500118145 0.390131504971534 no 1302 0.397681251990792 1982 16414116
SGTC_2536 dehydroabietamide 32.04 µM 0.259117673620037 0.390218084346686 no 1303 0.397772224401092 1947 3983547
SGTC_1829 berberine 14.4 µM 0.259100429906013 0.390224415273838 no 1304 0.397778876552944 1951 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_692 k241-0027 77.8 µM 0.257022158384607 0.390987653052115 no 1305 0.398580833809952 1940 3600480
SGTC_2250 alverine citrate 130 µM 0.255993626984669 0.391365533103637 no 1306 0.398977879163396 1804 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1155 4088-0394 48.2 µM 0.25355789806458 0.392260822658818 no 1307 0.399918563128328 1813 2326248
SGTC_2198 6589944 200 µM 0.252929263641723 0.39249197971795 no 1308 0.400161437708659 1924 5290268
SGTC_1683 st010134 710 nM 0.252746656286754 0.392559133932549 no 1309 0.400231995788273 1773 3818134
SGTC_169 k015-0017 16.025 µM 0.252598623029314 0.392613575802555 no 1310 0.400289197092282 1937 1840002
SGTC_934 2950-0684 338 µM 0.251975982765614 0.392842585856267 no 1311 0.400529813966801 1974 1121253
SGTC_1569 carminic acid 40.6 µM 0.251867791619837 0.392882382860225 no 1312 0.40057162786089 1981 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_166 k072-0058 166.424 µM 0.251580462017398 0.392988079543836 no 1313 0.400682681013931 1999 5846229
SGTC_3063 1327-0034 4 µM 0.250763532970429 0.393288637054165 no 1314 0.40099846866577 1932 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2061 5245884 80.95 µM 0.249238680818348 0.393849817596038 no 1315 0.401588080159106 1841 573863
SGTC_663 1486-0733 13.9 µM 0.248874917732029 0.393983723368925 no 1316 0.401728768853871 1871 722445 YPR165W RHO1
SGTC_1463 k081-0032 34.1 µM 0.247657735197388 0.394431874643369 no 1317 0.402199617828175 1889 977755
SGTC_814 3342-0569 96 µM 0.246284919087555 0.394937495938422 no 1318 0.402730841647911 1886 4346283
SGTC_3248 9135562 49.47 µM 0.245736327691315 0.395139596935611 no 1319 0.4029431744228 1855 17650701
SGTC_1613 st002381 52.1 µM 0.24221487431037 0.396437569458028 no 1320 0.404306835062543 2013 551167
SGTC_897 1000-0139 31.4 µM 0.240852353720016 0.396940089916606 no 1321 0.404834775668793 1996 6151020
SGTC_3294 9122953 26.2835 µM 0.24074589836764 0.396979359657289 no 1322 0.404876031605703 1868 16459826
SGTC_2935 9038016 29.96 µM 0.239772122347738 0.39733861907332 no 1323 0.405253459881105 2009 6463195
SGTC_237 nikkomycin 200 µM 0.238724764466174 0.397725122595224 no 1324 0.405659506299276 1971 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2238 6671620 73.2395 µM 0.238565125853248 0.397784042409995 no 1325 0.405721404948172 1818 729941
SGTC_2618 avocadyne 43.43 µM 0.234419861173908 0.399314799551051 no 1326 0.407329520586837 1905 3015189
SGTC_1952 st077036 64.1 µM 0.233810459946096 0.399539969515471 no 1327 0.407566064383921 2023 2937007
SGTC_1661 st013063 9.66 µM 0.230866742149265 0.400628124264808 no 1328 0.408709164362916 1886 721395
SGTC_3046 9092212 49.47 µM 0.230763916917993 0.400666147938241 no 1329 0.408749107400209 1911 25236637
SGTC_1290 0986-0249 10.2 µM 0.230598480022868 0.400727326712257 no 1330 0.408813374278205 2001 53329
SGTC_2431 5490079 200 µM 0.22868663636341 0.401434505232983 no 1331 0.409556241105717 1862 5722345
SGTC_2666 tannic acid 100 µM 0.228457583814929 0.401519251989015 no 1332 0.409645263708963 1932 16134267 A thiamine antagonist.
SGTC_1612 st002233 45.4 µM 0.22845551347212 0.401520018012698 no 1333 0.409646068380971 1997 1035021
SGTC_2656 pseudo-anisatin 100 µM 0.227654423247612 0.401816448550894 no 1334 0.409957453505222 1924 6708809 A neurotoxin.
SGTC_1228 0124-0032 52.5 µM 0.226827107958555 0.402122642552171 no 1335 0.410279091966496 1974 X1228
SGTC_1499 4480-0877 67.3 µM 0.226749916730449 0.402151214523055 no 1336 0.410309104971171 1997 2861909
SGTC_1938 st074717 56.4 µM 0.225392884586289 0.402653598864706 no 1337 0.410836823262464 1897 17250979
SGTC_2949 9072542 2.23 µM 0.224867708783904 0.402848066420057 no 1338 0.411041095315531 1856 16457352
SGTC_1671 st016596 74.5 µM 0.222843598843654 0.403597799329151 no 1339 0.411828617054223 1915 2829167
SGTC_2467 5474540 200 µM 0.221560752798077 0.404073150803268 no 1340 0.412327918922805 1944 5413519
SGTC_197 4544-0043 41.561 µM 0.221346902402311 0.404152405675752 no 1341 0.4124111663523 2002 896523
SGTC_2339 9000433 200 µM 0.220993124429916 0.404283527598034 no 1342 0.412548893273687 1837 2988954
SGTC_1136 pergolide 1.05886 µM 0.219835535721626 0.404712643683596 no 1343 0.41299962151831 1884 47811 A dopamine receptor agonist.
SGTC_3156 9099931 49.47 µM 0.218684298390497 0.4051395190156 no 1344 0.413447990512736 1905 18111053
SGTC_1129 3453-1384 223 µM 0.218110480036366 0.405352331319067 no 1345 0.413671516042339 1936 1084452
SGTC_1953 st076800 12.1 µM 0.217278403674608 0.405660973597612 no 1346 0.413995693223538 1815 297591
SGTC_2316 5844804 197.44 µM 0.216891151798778 0.405804637040783 no 1347 0.414146586662242 2044 776813
SGTC_1072 oxiconazole 14.9 nM 0.216246792980038 0.40604371062032 no 1348 0.414397690395409 1945 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_160 3453-0671 289.699 µM 0.21531499196195 0.406389494550207 no 1349 0.414760870921431 1919 5322268
SGTC_1937 st074714 47.2 µM 0.214406218432577 0.406726803498499 no 1350 0.415115146405712 1783 17250970
SGTC_296 1222-0039 74.9 µM 0.213785166321341 0.4069573588804 no 1351 0.415357296549382 1895 5984176
SGTC_2277 7947813 106.88 µM 0.212041284094682 0.407604918632548 no 1352 0.416037413246391 2018 1246798
SGTC_1978 st071761 42 µM 0.210768302500819 0.408077777346139 no 1353 0.416534036922604 1868 5147680
SGTC_3016 9080866 49.47 µM 0.208713900348436 0.408841182840834 no 1354 0.417335794103492 1941 17066299
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.208511972783892 0.408916236827115 no 1355 0.4174146175761 2012 17037758
SGTC_1154 4088-0362 150 µM 0.207842981900422 0.409164916338485 no 1356 0.417675785333852 1985 6618304
SGTC_3084 9116877 49.47 µM 0.207651812015506 0.409235985363646 no 1357 0.417750422938011 2053 27241325
SGTC_2646 retinol 96.75 µM 0.206132162304191 0.409801033957417 no 1358 0.418343838161207 1980 445354 A vitamin A analog and teratogen.
SGTC_1482 3346-2049 8.48 µM 0.206124130982379 0.409804020728015 no 1359 0.418346974845185 2017 3826804
SGTC_101 0490-5701 117.494 µM 0.20611928994036 0.409805821067063 no 1360 0.418348865547542 2050 4661669
SGTC_457 grayanotoxin iii 135 µM 0.206109125404977 0.409809601170571 no 1361 0.418352835383098 1970 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2885 9057732 51.95 µM 0.20203813972082 0.411324236202982 no 1362 0.419943453882986 1946 6471414
SGTC_1265 0819-1001 68.8 µM 0.201398864018373 0.411562203357269 no 1363 0.420193351697913 2013 3106768
SGTC_769 0302-0231 76 µM 0.200825947634096 0.411775496238051 no 1364 0.420417336484748 2019 571869 YER009W NTF2
SGTC_1170 0310-0127 64.8 µM 0.199804323363518 0.412155904674817 no 1365 0.420816809976783 1978 774975
SGTC_3198 9112019 49.47 µM 0.199321289905435 0.412335794087361 no 1366 0.42100571317842 1965 45595555
SGTC_402 epigallocatechin gallate 10 µM 0.19916184081015 0.412395179534897 no 1367 0.421068074022804 1910 65064 An antioxidant.
SGTC_528 3492-0019 172 µM 0.19914438676579 0.412401680265787 no 1368 0.421074900453027 2047 2869262
SGTC_2146 5545642 200 µM 0.198387201466313 0.412683715829777 no 1369 0.421371065096674 2041 825326
SGTC_221 trifluoperazine 10.304 µM 0.195712861595808 0.413680210942664 no 1370 0.422417458497773 2020 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1597 7-benzyloxygramine 47.5 µM 0.195582591126085 0.413728765734254 no 1371 0.422468443691687 1908 260807
SGTC_470 aa-861 153 µM 0.195149094639248 0.413890349310298 no 1372 0.422638114687811 1920 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2979 9012552 45.46 µM 0.191869161516377 0.415113398052533 no 1373 0.42392234707632 2122 17100905
SGTC_1939 st074455 53.6 µM 0.190285505860861 0.415704220138381 no 1374 0.424542705399641 2089 1644229
SGTC_454 lyso-paf C-16 6.67 µM 0.190036536880979 0.415797121573502 no 1375 0.42464024994676 1891 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2528 xanthyletin 44.79 µM 0.189866227454077 0.415860674330685 no 1376 0.42470697881341 1931 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_342 k048-0088 23.3 µM 0.188524722142514 0.41636134797637 no 1377 0.425232668747459 1938 6820570
SGTC_1402 3909-7673 35.9 µM 0.188219693847085 0.416475208932142 no 1378 0.425352217464572 2022 5328014
SGTC_3098 9119039 49.47 µM 0.187777474346026 0.41664029306197 no 1379 0.425525547256699 2087 17161528
SGTC_12 0849-0099 9.267 µM 0.187450774008575 0.416762262395203 no 1380 0.425653608073742 2072 6071388
SGTC_2788 5282734 71.43 µM 0.186975993309554 0.416939529892161 no 1381 0.425839727779002 2064 743706
SGTC_369 0957-0393 4.5 µM 0.186346325893769 0.417174653040852 no 1382 0.426086590408278 1905 6997992
SGTC_1243 0416-0003 5.65 µM 0.185517890620188 0.417484042905818 no 1383 0.426411424567812 1941 2141977
SGTC_2515 chrysin 20.77 µM 0.185199745484631 0.417602871908787 no 1384 0.42653618435635 2051 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1102 cgs 12066b 26.1 µM 0.184983493773824 0.417683647439056 no 1385 0.426620991100365 1983 6438352 A 5-HT1B full agonist.
SGTC_1692 fluoroquinolonic acid 71 µM 0.184729393978135 0.417778564632547 no 1386 0.426720644942085 2039 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2068 5226020 147 µM 0.184206821333709 0.417973783021869 no 1387 0.426925604200715 1940 1810509
SGTC_2019 4016004 108 µM 0.183424251618654 0.418266166762625 no 1388 0.42723257430958 1923 45595336
SGTC_145 3737-0113 38.366 µM 0.18316828783163 0.418361809778529 no 1389 0.427332988012423 2100 6849351
SGTC_2883 9059145 45.46 µM 0.182435330348178 0.418635712172952 no 1390 0.427620550703154 1960 16476510
SGTC_1279 0874-0590 65.2 µM 0.182273124850692 0.418696332858685 no 1391 0.427684194315747 2017 3523074
SGTC_3314 9135860 59.4275 µM 0.182009053040125 0.418795027935905 no 1392 0.427787810636301 2097 25252478
SGTC_278 4092-0821 23.9 µM 0.181588252914819 0.418952309734479 no 1393 0.427952934196568 2040 877900
SGTC_1479 0549-0158 134 µM 0.180637273052862 0.419307803657996 no 1394 0.42832614872612 1981 5440202
SGTC_2221 6807166 181.081 µM 0.179654539251383 0.41967523700721 no 1395 0.428711892532638 2055 674925
SGTC_1966 st070145 16.1 µM 0.179474841676764 0.419742431535941 no 1396 0.428782435008531 2009 3748532
SGTC_735 3076-0345 636 µM 0.179272719521432 0.419818014111089 no 1397 0.428861783245837 2068 2888990
SGTC_106 0092-0003 11.579 µM 0.179050629675614 0.419901066915228 no 1398 0.428948973627506 2091 1072148
SGTC_1435 4092-0789 56.7 µM 0.17766775951387 0.420418285694597 no 1399 0.42949195327311 2090 2248285
SGTC_2539 epi(13)torulosol 80 µM 0.176943000532401 0.420689413782296 no 1400 0.429776580972095 1950 6708597
SGTC_2489 cantharidin 73.42 µM 0.17641080036034 0.420888530714953 no 1401 0.429985610134157 2062 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1477 0139-0234 16 µM 0.174969325737799 0.42142794434854 no 1402 0.430551868129094 2084 620880
SGTC_177 1327-0068 8.361 µM 0.174889913279192 0.421457665548177 no 1403 0.43058306808077 2091 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_363 0455-0021 3.06 µM 0.174726856164341 0.421518693307899 no 1404 0.430647132108551 2009 4597466
SGTC_1738 st035555 74 µM 0.174537818144938 0.42158944735987 no 1405 0.430721406140984 2011 5331140
SGTC_1820 st053765 18.6 µM 0.174121014129251 0.421745459697215 no 1406 0.430885179286645 1948 3690829
SGTC_2343 7990716 14.84 µM 0.172926485162872 0.422192647288976 no 1407 0.431354606557763 2038 6456862
SGTC_1010 4112-3296 15.2 µM 0.172135639214419 0.422488766080821 no 1408 0.431665447440807 2140 704384
SGTC_1011 4112-3381 17.4 µM 0.172111408924906 0.422497839392498 no 1409 0.431674971790989 2029 2877139
SGTC_2793 7325131 81.82 µM 0.169620465815276 0.42343082036908 no 1410 0.432654313194163 2011 4176441
SGTC_2721 ifenprodil 61.44 µM 0.169566778602553 0.42345093362323 no 1411 0.432675425483778 2086 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1975 st070967 30.8 µM 0.169243447328322 0.423572069925944 no 1412 0.432802578324213 2135 261391
SGTC_2900 5328528 85.29 µM 0.168856373998576 0.423717096736447 no 1413 0.432954807433235 2048 795359
SGTC_796 1234-0020 70.7 µM 0.168682003257975 0.423782432520736 no 1414 0.43302338762009 2113 46495034
SGTC_2446 5162541 200 µM 0.166335946490454 0.42466169048294 no 1415 0.433946289425095 1977 1549321
SGTC_2961 9083290 32.55 µM 0.165565374050455 0.424950568570568 no 1416 0.434249499323329 2119 17741490
SGTC_726 3448-4391 34.2 µM 0.165299174333015 0.425050372930808 no 1417 0.434354254333741 2071 1356692
SGTC_847 0342-0274 5.54 µM 0.163728258637517 0.425639442758126 no 1418 0.434972535279633 2105 18097
SGTC_544 k015-0020 52.4 µM 0.16043320780329 0.426875575198015 no 1419 0.436269916179417 2009 3008304
SGTC_2428 5615643 7.78 µM 0.160041415579227 0.427022603382034 no 1420 0.436424224876285 2071 2253075
SGTC_2487 5918373 44.05 µM 0.158467463328352 0.427613363691403 no 1421 0.437044228591498 2171 2876279
SGTC_3351 9150312 21.596 µM 0.157643233974174 0.427922791154519 no 1422 0.437368966858705 2134 4904905
SGTC_1322 1348-1070 12 µM 0.155835100092454 0.428601745455451 no 1423 0.438081501363328 2111 6758089
SGTC_1295 1013-0063 9.78 µM 0.155086978649897 0.428882727002534 no 1424 0.43837637375667 2142 6826038
SGTC_2335 9018011 154.17 µM 0.155020008082779 0.428907881755628 no 1425 0.438402771905823 2111 6458208
SGTC_2011 4012611 177 µM 0.15422954726852 0.429204807805617 no 1426 0.438714372778629 2022 2049887
SGTC_759 3486-0358 89.3 µM 0.154113422444595 0.429248431924209 no 1427 0.438760152568464 2168 875103
SGTC_1423 4048-0112 5.59 µM 0.153826688046959 0.429356151915551 no 1428 0.438873195132196 2135 X1423
SGTC_1143 3454-2408 5.08 µM 0.153073266945713 0.429639221189007 no 1429 0.439170248644534 2114 X1143
SGTC_2732 terfenadine 20 µM 0.152117883687188 0.429998222054966 no 1430 0.439546979606007 2157 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2771 fluoxetine 41.05 µM 0.151910624273131 0.430076110816082 no 1431 0.439628714296093 2108 3386 A selective serotonin reuptake inhibitor.
SGTC_2091 4-phenylthiadiazole 200 µM 0.151196270490575 0.430344588122098 no 1432 0.439910446096418 2047 270010
SGTC_2364 9055074 200 µM 0.149508684969168 0.430978965146396 no 1433 0.440576128388529 2012 6470630
SGTC_2782 7736369 71.43 µM 0.147898463506816 0.431584426483654 no 1434 0.441211450407873 2016 2950836 YOL077C BRX1
SGTC_1330 1469-0054 61.8 µM 0.145992297558959 0.432301373971512 no 1435 0.441963734468407 2167 7102664
SGTC_964 1287-0107 19.4 µM 0.145855741216772 0.432352744155233 no 1436 0.442017635620323 2129 51516812 YPR165W RHO1
SGTC_1255 0566-0045 221 µM 0.145788878586685 0.432377897161634 no 1437 0.442044027849331 2055 2788469
SGTC_2991 9074669 71.4286 µM 0.14319008325174 0.433355747535112 no 1438 0.4430700307677 2113 17333109
SGTC_2126 5251174 33.877 µM 0.141219078290394 0.434097651305647 no 1439 0.443848437407677 2158 790722
SGTC_56 0957-0365 83.25 µM 0.140256410465269 0.434460092587162 no 1440 0.444228701612633 2161 6752360
SGTC_1187 1391-0724 117 µM 0.139102652715111 0.434894551157617 no 1441 0.44468451602206 2052 6997986
SGTC_3091 9116372 49.47 µM 0.138999357552768 0.434933451786101 no 1442 0.444725328359308 2086 17169793
SGTC_2953 9074162 66.49 µM 0.138014043776938 0.435304549414544 no 1443 0.445114659218016 2179 16451992
SGTC_2497 7-hydroxyflavone 100 µM 0.137714215877768 0.435417484585439 no 1444 0.445233141904536 2159 5281894
SGTC_441 propafenone 146 µM 0.13650510628386 0.435872969209912 no 1445 0.445710994053257 2121 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1747 st037496 66.6 µM 0.135479143313625 0.43625952726924 no 1446 0.446116526719577 2094 723305
SGTC_1697 st025554 27.742 µM 0.135147432661397 0.436384520872035 no 1447 0.446247654160112 2137 1269519
SGTC_2321 7390090 138.78 µM 0.134661573484192 0.436567611439615 no 1448 0.446439728151142 2004 649046
SGTC_2965 9082772 38.63 µM 0.134653037999313 0.4365708280627 no 1449 0.446443102584232 2184 16459634
SGTC_1933 st074711 15.9 µM 0.134131385206178 0.436767422436014 no 1450 0.446649341037959 2180 17250958
SGTC_970 1315-0089 19.5 µM 0.133072196843702 0.437166644896716 no 1451 0.447068141632923 2162 6811083 YLR033W RSC58
SGTC_1678 st019265 80.2 µM 0.132268867349327 0.437469473371404 no 1452 0.44738581562169 2187 5367020
SGTC_132 0417-1715 25.805 µM 0.131862231754904 0.437622775428831 no 1453 0.447546631201967 2189 6769098
SGTC_2664 lyso-paf C-16 73.48 µM 0.131539125688669 0.437744593441491 no 1454 0.447674418810306 2166 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2725 haloperidol 53.21 µM 0.131005440347399 0.437945817336823 no 1455 0.447885501861949 2170 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_483 fpl-64176 144 µM 0.130446699982518 0.43815650532155 no 1456 0.448106510481448 2166 3423
SGTC_2699 st077704 54.6 µM 0.12613773768805 0.43978189918485 no 1457 0.449811447835165 2092 645852
SGTC_170 4197-0004 226 µM 0.126042906852329 0.439817682069767 no 1458 0.449848980315841 2107 218692
SGTC_118 0083-0097 135.343 µM 0.125970315130692 0.439845073716237 no 1459 0.449877711225127 2116 5207356
SGTC_1912 st060209 90.8 µM 0.125808949875 0.439905964060215 no 1460 0.449941578546648 2053 688787
SGTC_2066 5222451 176 µM 0.125525770913202 0.440012823610863 no 1461 0.450053662076144 2180 2281147
SGTC_2617 dihydrotanshinone i 20.83 µM 0.123768753792742 0.440675943615913 no 1462 0.450749186204207 2116 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_590 k048-0076 22.4 µM 0.123286664215552 0.440857919357786 no 1463 0.45094005034141 2198 6832814
SGTC_2899 9053889 58.44 µM 0.123251941416919 0.440871026755268 no 1464 0.450953797886902 2218 6470052
SGTC_2401 5128683 200 µM 0.123026606916915 0.440956089123872 no 1465 0.451043014368089 2086 708373
SGTC_2213 7173844 200 µM 0.122448846602985 0.441174202477204 no 1466 0.451271777767522 2167 892728
SGTC_216 k038-0035 28.382 µM 0.122320061879592 0.441222823113909 no 1467 0.451322772109667 2176 4444231 YPR107C YTH1
SGTC_713 1488-1073 324 µM 0.122154700881647 0.441285253843817 no 1468 0.451388250582351 2207 3312542
SGTC_1486 3970-0793 4.53 µM 0.121138480064241 0.441668951908903 no 1469 0.451790675452897 2206 2844330
SGTC_433 pimozide 108 µM 0.121017451388981 0.44171465278637 no 1470 0.45183860628781 2084 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2280 7785178 200 µM 0.120090044294772 0.442064870859521 no 1471 0.452205909408804 2102 2954328
SGTC_134 0269-0018 6.916 µM 0.119513423804571 0.442282643734429 no 1472 0.452434302800931 2071 4378915
SGTC_2101 5377231 179.231 µM 0.119021029560095 0.4424686206034 no 1473 0.45262934751334 2143 2844213
SGTC_1546 5-methoxyflavanone 78.7 µM 0.118740478305689 0.442574590235898 no 1474 0.452740483169218 2197 147795
SGTC_2916 7875993 68.79 µM 0.11858828780173 0.442632077250871 no 1475 0.452800772424465 2225 1299250
SGTC_416 estradiol valerate 100 µM 0.11779871671268 0.442930341798009 no 1476 0.453113573191856 2093 13791 A steroid.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.117759711895807 0.442945076908297 no 1477 0.453129026307505 2125 6708561
SGTC_2438 5259590 200 µM 0.117192051003595 0.443159534877493 no 1478 0.453353932947305 2178 1201127
SGTC_1092 toremifene 6.32 µM 0.115741534221945 0.443707604582418 no 1479 0.45392869394401 2213 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_230 MPP+ 141.667 µM 0.115288925524377 0.443878642356679 no 1480 0.454108057991277 2066 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1851 st056236 18.9 µM 0.112863477618557 0.444795380098678 no 1481 0.455069395953438 2216 5393171
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.112534763704702 0.444919645738815 no 1482 0.455199703672905 2053 4174840
SGTC_203 k066-0004 30.888 µM 0.112218170574174 0.445039334406032 no 1483 0.455325211067394 2217 6795412
SGTC_80 0159-0065 512.242 µM 0.111998785189868 0.445122276429751 no 1484 0.455412184894747 2208 1548079
SGTC_204 PMA1.184 62.41 µM 0.111758386482088 0.445213165622553 no 1485 0.455507491763469 2218 2252213 YGL008C PMA1
SGTC_778 3456-2434 196 µM 0.11155301947146 0.445290812421891 no 1486 0.455588912227417 2209 5539063
SGTC_310 1273-0058 1.06 µM 0.110681416889496 0.445620378207347 no 1487 0.455934491300556 2189 2734232
SGTC_2007 4011539 71.82 µM 0.110450112189627 0.445707844243352 no 1488 0.456026206210316 2146 45595301
SGTC_1967 st070177 51.4 µM 0.109973284186125 0.445888161301162 no 1489 0.456215281254312 2171 5729214
SGTC_142 0335-0849 62.6745 µM 0.109146817117338 0.446200724197444 no 1490 0.4565430209913 2193 3889043 YPR107C YTH1
SGTC_2115 tiliquinol 12.7705 µM 0.10815866691826 0.446574478161121 no 1491 0.456934915787593 2161 71208 A bioactive hydroxyquinoline.
SGTC_1374 2889-5571 141 µM 0.107397861459844 0.446862274521116 no 1492 0.457236675501578 2115 2853281
SGTC_2799 7812892 81.82 µM 0.107083035512388 0.446981374608845 no 1493 0.45736155273776 2179 20205235
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.106647629874359 0.447146098419391 no 1494 0.457534265426835 2195 140250 A respiratory chain inhibitor.
SGTC_347 4534-1311 26.2 µM 0.105422042744089 0.44760981464222 no 1495 0.458020462970533 2200 2862016
SGTC_2821 7996764 71.43 µM 0.104274377100835 0.448044113240325 no 1496 0.458475805579297 2153 2987135
SGTC_1232 0279-0259 161 µM 0.103261998753958 0.448427268263869 no 1497 0.458877517471923 2113 1560000
SGTC_1879 gemcitabine 100 µM 0.10257271220568 0.448688170226345 no 1498 0.459151050542526 2196 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1172 0370-0043 85 µM 0.10200143604068 0.448904420882864 no 1499 0.459377767617596 2161 376585
SGTC_1239 0337-0584 35.4 µM 0.0992621418425065 0.449941562034811 no 1500 0.460465068177688 2216 914301 YML130C ERO1
SGTC_83 0170-0301 39.027 µM 0.0991266349277681 0.44999287608331 no 1501 0.460518862308742 2236 3089716
SGTC_1567 st069303 68.4 µM 0.098388239923065 0.450272507753317 no 1502 0.460812006276745 2127 5581319
SGTC_867 0518-0118 155 µM 0.0983042428523833 0.450304319179136 no 1503 0.460845354596879 2246 6848158
SGTC_613 3914-0030 117 µM 0.0965421228363087 0.450971743726548 no 1504 0.461545010479626 2215 1145395
SGTC_1881 5652484 16 µM 0.0957135622625092 0.451285619234207 no 1505 0.461874034613793 2239 2255129
SGTC_952 1185-0122 232 µM 0.0951076191001427 0.451515182057278 no 1506 0.462114673172523 2231 678600
SGTC_826 1683-5028 118 µM 0.0940952127227731 0.451898770452359 no 1507 0.462516761602073 2148 722377
SGTC_3330 9141424 71.43 µM 0.0930634463829917 0.452289740304878 no 1508 0.462926578464473 2231 27261020
SGTC_1828 st055811 49 µM 0.092886002902366 0.452356984089252 no 1509 0.462997062867732 2246 5877589
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0925217138295502 0.452495038952392 no 1510 0.463141770035414 2257 688664
SGTC_1574 spiramycin 23.7 µM 0.0924390565921873 0.452526364418571 no 1511 0.463174604789904 2229 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_741 4582-0002 126 µM 0.0915443778858901 0.452865448908592 no 1512 0.463530022896726 2173 2912688
SGTC_2969 9091408 28.7 µM 0.0906916420998588 0.453188668971517 no 1513 0.463868805950669 2016 4286311
SGTC_1522 st012842 45.6 µM 0.0903084922352248 0.45333390779887 no 1514 0.46402103595047 2209 3491067 YOR116C RPO31
SGTC_428 3448-4153 16.5 µM 0.0890877951593592 0.45379667326157 no 1515 0.464506068438796 2168 3834874
SGTC_2141 5621638 7.665 µM 0.0889169447534495 0.453861447557876 no 1516 0.464573958463286 2233 2856238
SGTC_1704 st028805 70.8 µM 0.0887563023826244 0.453922352814388 no 1517 0.464637793109553 2133 2876101
SGTC_1617 st002906 78 µM 0.0880908096101058 0.454174676404506 no 1518 0.4649022504259 2232 5150859
SGTC_801 0866-0028 10.1 µM 0.087579188561089 0.454368671647597 no 1519 0.465105571865863 2243 6849771
SGTC_1840 st055363 71 µM 0.0865725806789907 0.454750386546271 no 1520 0.465505630749268 2094 676033
SGTC_2236 dapsone 200 µM 0.0857021226554388 0.45508050588113 no 1521 0.465851607352048 2272 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0851739578901215 0.45528082637045 no 1522 0.466061546961736 2109 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1911 st060208 74.3 µM 0.083543062850978 0.455899458095279 no 1523 0.466709868921526 2220 688783
SGTC_1258 0671-0043 57.1 µM 0.0834417238086404 0.455937901603319 no 1524 0.466750156682564 2169 4298767
SGTC_2776 terbinafine 19.92 µM 0.0829923312672829 0.456108386034707 no 1525 0.466928818670356 2257 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1123 mangostin 811.285 nM 0.082447808839874 0.456314970373837 no 1526 0.46714530973615 2115 5281650 An antioxidant.
SGTC_479 n-linoleoylglycine 10 µM 0.0817964834082709 0.456562089813494 no 1527 0.467404276269384 2154 6433346 An anti-infammatory.
SGTC_1899 st063254 59.6 µM 0.0799534654430064 0.457261440142128 no 1528 0.468137133310958 2237 3093813
SGTC_1094 duloxetine 25.4 µM 0.0791245421745839 0.457576026081346 no 1529 0.468466781437851 2260 60834 A selective serotonin reuptake inhibitor.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0777001736899056 0.458116652320313 no 1530 0.469033277970429 2178 6857784
SGTC_1743 st037606 46.3785 µM 0.0776108656980439 0.458150552211022 no 1531 0.469068799438746 2217 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_263 alizarin 107.927 µM 0.0756819179521729 0.458882823923888 no 1532 0.46983608105647 2276 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1238 0333-0287 48.8 µM 0.0751486334635202 0.45908529537239 no 1533 0.4700482266402 2237 7226
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0751195602834585 0.459096333855516 no 1534 0.470059792469517 2244 688751
SGTC_420 mitomycin C 81.9 mM 0.0747834978228969 0.459223932084623 no 1535 0.470193485938348 2268 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_932 2857-0803 154 µM 0.0747553486957401 0.459234620106447 no 1536 0.470204684469031 2261 674898
SGTC_1778 st046819 58.9 µM 0.0742322019334371 0.459433260536541 no 1537 0.470412811544962 2279 671715
SGTC_37 0566-0070 1.56 µM 0.072888529019479 0.459943503556852 no 1538 0.470947411089729 2254 1626686
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0726559026817234 0.460031847228805 no 1539 0.47103997015947 2259 6710655
SGTC_1358 1509-0022 2.48 µM 0.071882368036917 0.460325623878587 no 1540 0.471347761007266 2220 3258434
SGTC_1695 st026914 34.495 µM 0.0717377378652381 0.460380554618106 no 1541 0.471405311521363 2226 3289191
SGTC_561 1550-0330 72.9 µM 0.0716175885827721 0.460426188057012 no 1542 0.471453121176656 2215 6812934
SGTC_2750 bromebric acid 70.15 µM 0.0712226134431537 0.46057620572222 no 1543 0.4716102920958 2211 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3240 9133527 49.47 µM 0.070985139561844 0.460666404676708 no 1544 0.471704791282473 2253 17617455
SGTC_2673 kobusone 100 µM 0.0708140084648072 0.460731406115926 no 1545 0.471772891336254 2279 6710676 An epoxy ketone and protein crosslinker.
SGTC_3082 9117008 49.47 µM 0.0708044307621318 0.460735044085751 no 1546 0.471776702719778 2165 41448529
SGTC_172 1112-0046 2.638 µM 0.0702145511251993 0.460959108764485 no 1547 0.472011446393589 2207 2802135 YIL048W NEO1
SGTC_1441 4106-0040 13 µM 0.0699351340306569 0.461065249156773 no 1548 0.472122644332845 2276 2904180
SGTC_1308 1187-1617 41.4 µM 0.0687747622356361 0.461506061793178 no 1549 0.472584453663757 2267 2882570
SGTC_2838 9002687 71.43 µM 0.0673704538977781 0.462039606477181 no 1550 0.473143395053556 2224 6457060
SGTC_909 3448-9333 149 µM 0.0660154921834511 0.46255446746413 no 1551 0.473682745690688 2244 3344074
SGTC_2689 tacrolimus 100 µM 0.0655764178452047 0.462721321286756 no 1552 0.473857532262348 2217 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1688 st021091 57.6 µM 0.0648295045203228 0.463005172886537 no 1553 0.474154874823302 2296 3656366
SGTC_2105 5350118 200 µM 0.064721564328204 0.463046195266677 no 1554 0.474197846483293 2228 2133313
SGTC_1118 chelidonine 707.474 nM 0.0630210077265451 0.463692538821358 no 1555 0.474874887911874 2300 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2978 9011784 42.97 µM 0.0625724308521351 0.463863048910156 no 1556 0.475053491688625 2292 2994934
SGTC_756 0508-1999 28.3 µM 0.0618352181330828 0.464143287760525 no 1557 0.475347028562148 2225 6753853
SGTC_2803 7707263 71.43 µM 0.0611966572768587 0.464386040170097 no 1558 0.475601295925934 2250 2199229
SGTC_3281 9140613 49.47 µM 0.0603914026605709 0.46469218101564 no 1559 0.475921952922009 2114 16013766
SGTC_1638 st008370 60.6 µM 0.058789459326687 0.465301268108192 no 1560 0.476559902089512 2318 24207134
SGTC_1256 0570-0116 285 µM 0.058495864093398 0.465412907048759 no 1561 0.476676828415442 2241 410638
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.058163047066427 0.465539463281448 no 1562 0.476809377519033 2282 390807
SGTC_3036 9090181 49.47 µM 0.0581225179093338 0.465554875043272 no 1563 0.476825519006493 2299 25236586
SGTC_255 tunicamycin 200.472 nM 0.057599644021551 0.465753709557129 no 1564 0.477033766616773 2300 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1396 3511-0007 98.6 µM 0.0547750481231054 0.466827972032516 no 1565 0.478158839632089 2259 X1396
SGTC_1027 k015-0025 8.67 µM 0.0547598168460824 0.466833765519568 no 1566 0.478164906926313 2323 3598955
SGTC_1802 st050112 57.9 µM 0.0547224967880309 0.466847960896957 no 1567 0.478179773184609 2304 4662563
SGTC_872 0588-0139 234 µM 0.0546913858346218 0.466859794558275 no 1568 0.478192166100359 2316 2047100
SGTC_3295 9122362 53.5725 µM 0.0539943168704535 0.467124946072454 no 1569 0.47846984605939 2236 4730473
SGTC_2911 7942208 15.64 µM 0.0527600233406995 0.467594483105336 no 1570 0.478961556932293 2229 1243384
SGTC_173 1273-0061 2.693 µM 0.0524688064728895 0.467705271378431 no 1571 0.479077574957037 2246 2847414 YPL266W DIM1
SGTC_2716 st080858 38.6235 µM 0.0511560889005513 0.468204702338817 no 1572 0.47960057099082 2320 5296050
SGTC_1800 st050079 29.0735 µM 0.0481910658170105 0.469332945420875 no 1573 0.480781985180842 2299 3645560
SGTC_2826 7992541 19.48 µM 0.047655335809914 0.469536826582379 no 1574 0.480995465245499 2339 2985066
SGTC_2571 chrysanthemic acid 100 µM 0.045796766564317 0.470244198287395 no 1575 0.481736118008225 2212 2743 An insecticide.
SGTC_1177 0983-0204 23.6 µM 0.0450613497771769 0.470524124071043 no 1576 0.482029204260034 2327 766818
SGTC_2034 5197015 53.07 µM 0.0443153623662991 0.470808088290831 no 1577 0.482326513153489 2302 780676
SGTC_568 1193-0097 7.48 µM 0.0440261151679224 0.470918195832666 no 1578 0.482441793575962 2318 3646150
SGTC_1188 1403-0014 4.57 µM 0.042874199628251 0.471356716742265 no 1579 0.482900907773656 2304 9614867
SGTC_3044 9093193 49.47 µM 0.0418969754296341 0.471728761931332 no 1580 0.483290413770072 2284 25236277
SGTC_1070 indatraline 8.81 µM 0.0414114094844486 0.471913634000643 no 1581 0.483483958573716 2275 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2432 5630864 12.22 µM 0.0413960118367557 0.471919496527019 no 1582 0.483490096083478 2292 5714970
SGTC_2368 9071271 200 µM 0.0399657607674806 0.47246407909391 no 1583 0.484060211710801 2284 27209959
SGTC_68 0986-0284 82.829 µM 0.0378405985041065 0.473273350898931 no 1584 0.484907387306369 2119 423278 YIL048W NEO1
SGTC_991 3996-0057 64.7 µM 0.037623245628139 0.473356126173402 no 1585 0.484994036854838 2308 715343
SGTC_903 1134-0042 114 µM 0.0365696888386117 0.473757372219228 no 1586 0.485414056079838 2328 701009
SGTC_2072 5231554 129 µM 0.036284569525727 0.473865964218042 no 1587 0.485527726786437 2343 789545
SGTC_1761 st044296 37 µM 0.0358865175938573 0.4740175715576 no 1588 0.485686423172609 2348 1826700
SGTC_2601 securinine 100 µM 0.0352937722848026 0.474243339367124 no 1589 0.485922744617764 2315 442872 A GABA receptor antagonist.
SGTC_1153 4055-0057 267 µM 0.0350785179561964 0.474325328567865 no 1590 0.486008565527948 2333 882706
SGTC_1949 st076024 69.1 µM 0.0323074760928206 0.475380899194966 no 1591 0.487113423629274 2339 2921930
SGTC_3079 9117512 49.47 µM 0.032003639147068 0.475496650192179 no 1592 0.487234574382903 2356 7185044
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0318060184088448 0.475571937728057 no 1593 0.487313373534987 2327 7104
SGTC_1763 st044482 94.5 µM 0.0312147654102685 0.475797192470568 no 1594 0.487549132279048 2333 88505
SGTC_246 cycloheximide 667 µM 0.0310514358046666 0.475859418922443 no 1595 0.487614259793571 2317 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2833 9001315 45.46 µM 0.0302258794754002 0.47617395410622 no 1596 0.487943454560493 2275 2989378
SGTC_1485 3909-9022 254 µM 0.0300732162480083 0.476232120099514 no 1597 0.488004330702153 2342 714516
SGTC_2972 9093619 59.92 µM 0.0298992186924911 0.476298415271501 no 1598 0.488073714482616 2347 25236256
SGTC_1127 asiatic acid 681.4 nM 0.0294487884171178 0.47647003769434 no 1599 0.488253331064531 2344 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1810 st050138 53 µM 0.0286624036694704 0.476769675545128 no 1600 0.488566920782455 2359 3444541
SGTC_1509 1326-1131 80 µM 0.0285638602276756 0.476807224691668 no 1601 0.488606217838062 2340 768313
SGTC_393 acivicin 6.25 µM 0.0275922899936163 0.477177444298102 no 1602 0.488993665509801 2338 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3070 9117005 49.47 µM 0.0267852393632668 0.477484988231923 no 1603 0.489315513138415 2360 8779016
SGTC_1845 st056753 3.01 µM 0.0261147648786875 0.477740497104591 no 1604 0.489582900204532 2350 5375839
SGTC_589 1227-0070 34.1 µM 0.0260606087032904 0.477761135700632 no 1605 0.489604498041997 2339 2841384
SGTC_1163 k060-0048 49.9 µM 0.0242809284717572 0.478439394099847 no 1606 0.490314262760734 2358 6809982
SGTC_720 r052-1644 49.9 µM 0.0240177484923693 0.478539700629759 no 1607 0.490419225770384 2343 1422863 YOR257W CDC31
SGTC_2067 5224629 34.075 µM 0.0233067716887868 0.478810684008038 no 1608 0.490702785077844 2339 2835000
SGTC_2566 crystal violet carbinol 226 nM 0.0217985602387971 0.479385559556624 no 1609 0.491304321339067 2290 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1288 0973-0013 65.5 µM 0.0217692369866676 0.479396736946555 no 1610 0.491316016848828 2335 4315430
SGTC_672 1441-0018 53.7 µM 0.0217556694165322 0.479401908616529 no 1611 0.491321428244615 2365 251141
SGTC_158 k038-0087 26.446 µM 0.0209054100744912 0.479726016326607 no 1612 0.491660555476396 2317 X158
SGTC_603 3794-0023 45.9 µM 0.0201012290521191 0.480032571924012 no 1613 0.491981309851247 2366 3802260
SGTC_1026 k007-1105 30.6 µM 0.0200644873350579 0.480046578231914 no 1614 0.491995964720028 2372 7066794
SGTC_2585 alliin 100 µM 0.0192313784286236 0.480364174210519 no 1615 0.492328262930774 2356 87310 A garlic compound which reacts with lipids.
SGTC_1497 4476-2978 41.3 µM 0.0177839364756231 0.480915994430966 no 1616 0.492905609785108 2341 1528379
SGTC_1982 st072467 71.9 µM 0.01716736543401 0.481151066057199 no 1617 0.493151548481077 2343 3163533
SGTC_3269 9137823 49.47 µM 0.0157411138985642 0.481694858494437 no 1618 0.493720463453038 2371 17682936
SGTC_758 0868-0029 16 µM 0.0153207743861761 0.481855129509189 no 1619 0.493888134432221 2385 762687
SGTC_184 1494-0393 24.714 µM 0.0153053789324959 0.481860999688838 no 1620 0.493894275609555 2358 3090647
SGTC_979 1426-2828 121 µM 0.0144545723223177 0.48218541242331 no 1621 0.494233660754229 2359 747872
SGTC_812 4251-0442 148 µM 0.014105422598991 0.482318546710166 no 1622 0.494372937139119 2384 5723007
SGTC_2295 7971645 200 µM 0.0122589154371987 0.483022670822531 no 1623 0.495109522811516 2367 2978226 YKL099C UTP11
SGTC_1373 2887-0003 58.5 µM 0.0116902020727467 0.483239547683483 no 1624 0.49533639034911 2364 776948
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0102773492326602 0.483778355520009 no 1625 0.495900003037051 2390 616764
SGTC_1587 estradiol valerate 56.1 µM 0.00921572189633985 0.484183238978815 no 1626 0.496323510931617 2388 13791 A steroid.
SGTC_1210 3013-0140 750 nM 0.0090295276041521 0.484254251455248 no 1627 0.49639778861619 2395 905973
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0082377434774658 0.484556234853358 no 1628 0.496713653000593 2378 5379071
SGTC_942 3253-1115 227 µM 0.00821602871188614 0.484564516906405 no 1629 0.496722315645536 2389 46497897
SGTC_3278 9139605 49.47 µM 0.00470860768522577 0.485902338877826 no 1630 0.498121544253746 2393 7958859
SGTC_2360 9040895 200 µM 0.00348695689273386 0.486368346420484 no 1631 0.498608908284569 2388 4914414
SGTC_2658 polymyxin b sulfate 77.05 µM 0.00230368314391831 0.486819732515538 no 1632 0.499080964206123 2399 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1741 st038134 10.228 µM -0.00221431480263934 0.488543373675358 no 1633 0.499116616925008 2416 1272587
SGTC_2848 9016370 25.97 µM -0.00234394637508117 0.48859283214792 no 1634 0.499064901544238 2413 7894410
SGTC_2801 7907800 81.82 µM -0.00247886738061621 0.488644308889841 no 1635 0.499011076007152 2412 6620925
SGTC_3180 9109287 49.47 µM -0.00417130613164205 0.489290044983775 no 1636 0.498335894445441 2413 18891271
SGTC_408 cantharidin 100 µM -0.0058338914524079 0.489924418092094 no 1637 0.497672627242116 2424 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3022 9087993 49.47 µM -0.00617193956147196 0.490053406299663 no 1638 0.497537767989091 2416 17173644
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.00646625354142438 0.490165707827862 no 1639 0.497420356043409 2422 65057 A dermal irritant. YDR527W RBA50
SGTC_911 3456-4043 236 µM -0.007350249558412 0.49050301926884 no 1640 0.497067701083151 2427 914281
SGTC_974 1326-0144 138 µM -0.00742671841000725 0.49053219825068 no 1641 0.497037195257786 2422 5411856
SGTC_1248 0469-0687 58.6 µM -0.00862364697173792 0.490988928715333 no 1642 0.496559705252669 2426 4017482
SGTC_495 decylubiquinone 155 µM -0.00876633420474532 0.491043376880214 no 1643 0.496502783434364 2438 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1063 disulfiram 1.84 µM -0.00881661856322906 0.49106256497901 no 1644 0.49648272365295 2427 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1267 0828-0272 9.49 µM -0.00887323802211689 0.491084170524917 no 1645 0.496460136640448 2420 745334
SGTC_971 1315-0384 26.7 µM -0.009113617669089 0.491175897822361 no 1646 0.496364242914258 2430 6769120
SGTC_1928 4'-methoxychalcone 40.3 µM -0.00926759513499511 0.491234654859432 no 1647 0.496302817387217 2427 641818
SGTC_1205 4161-2785 76 µM -0.0101709091537017 0.491579358796655 no 1648 0.495942464265503 2458 3498106
SGTC_1785 bathophenanthroline 24 µM -0.0118171416871447 0.492207575861654 no 1649 0.495285752267819 2432 72812 An iron chelator.
SGTC_3288 9119690 36.221 µM -0.0120273464169234 0.492287793291604 no 1650 0.495201898673407 2439 17595618 YKL019W RAM2
SGTC_658 3253-0951 102 µM -0.012279749340634 0.492384114627653 no 1651 0.49510121191214 2440 1184878
SGTC_777 1315-0167 517 µM -0.0124952004262826 0.492466334852541 no 1652 0.495015265959319 2460 4221767
SGTC_3308 9128332 17.569 µM -0.0129393823706484 0.492635844122099 no 1653 0.494838077331871 2433 17332805 YDL196W YDL196W
SGTC_855 0428-0020 25 µM -0.0131138813951644 0.492702437023767 no 1654 0.494768468199537 2442 6812414
SGTC_2502 avocadyne acetate 18.59 µM -0.0146845802018786 0.493301861290193 no 1655 0.494141910624983 2427 3952079
SGTC_1332 1480-0653 17.5 µM -0.0150817581319082 0.493453438368734 no 1656 0.493983477105068 2427 5749438
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0160400050114799 0.493819142956605 no 1657 0.49360123820503 2440 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3012 9080433 71.4286 µM -0.0174901553154602 0.494372586960909 no 1658 0.493022793283378 2436 17688859
SGTC_2462 5162487 171.77 µM -0.0192140091793492 0.495030502827194 no 1659 0.492335190978572 2430 2259986
SGTC_1790 st045711 43.5 µM -0.0203423527881969 0.495461147203956 no 1660 0.491885135064297 2454 585119
SGTC_1954 st077032 68.9 µM -0.0215268824201809 0.495913241257979 no 1661 0.491412679679396 2487 698907
SGTC_2257 7960413 200 µM -0.0221312492055636 0.496143909247459 no 1662 0.491171629657492 2476 2974689 YIL048W NEO1
SGTC_52 0329-0193 875 nM -0.0234007381971894 0.496628437785488 no 1663 0.490665308086044 2513 3739292
SGTC_738 1315-0003 72.4 µM -0.0238512092534369 0.496800371255101 no 1664 0.490485646286534 2468 6251474
SGTC_1378 2093-0007 380 nM -0.02488076394292 0.497193328559453 no 1665 0.49007503531727 2477 3618014
SGTC_1751 st044839 27.194 µM -0.0250827554548472 0.497270424397267 no 1666 0.489994477504535 2444 5291326
SGTC_2035 5154463 94.595 µM -0.0258030151206827 0.497545332909127 no 1667 0.489707228466175 2452 2769623
SGTC_599 1935-0052 86.5 µM -0.0265091380255193 0.497814846838293 no 1668 0.489425622535591 2458 9557311
SGTC_2724 maprotiline 69.64 µM -0.0268226352302513 0.497934503195203 no 1669 0.489300599704212 2441 4011 A tricyclic antidepressant.
SGTC_2459 5811157 9.22 µM -0.02708745120473 0.498035578929857 no 1670 0.489194991788746 2457 2870684 YBR192W RIM2
SGTC_1115 galangin 695.678 nM -0.0275490732281505 0.498211772469787 no 1671 0.489010899953205 2447 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_694 1315-0438 43.2 µM -0.0288850757529029 0.498721704520602 no 1672 0.488478124240078 2480 6793154
SGTC_3027 9089541 49.47 µM -0.0292177673148306 0.49884868823851 no 1673 0.488345455507334 2490 9943819
SGTC_451 chloral hydrate 100 µM -0.0293447944761401 0.498897172761516 no 1674 0.488294800722157 2495 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2370 9071495 200 µM -0.0294558036471172 0.49893954345095 no 1675 0.488250533606251 2505 21791103
SGTC_1407 3909-7909 12.3 µM -0.0315751188544951 0.49974845895751 no 1676 0.487405442885666 2470 4411780
SGTC_3345 9148410 3.559 µM -0.0316841492838573 0.499790074534205 no 1677 0.487361967789981 2468 4903596
SGTC_600 1495-0418 41.6 µM -0.0322341419237693 0.5 no 1678 0.487142664500139 2472 5377768
SGTC_34 0469-0683 81.75 µM -0.0328202132693819 0.499776303734778 no 1679 0.486908979518464 2491 3690923
SGTC_1291 0993-0025 5.79 µM -0.033729481564012 0.49942924731147 no 1680 0.486546434727158 2487 4353356
SGTC_2934 9036370 36.88 µM -0.0340778013752045 0.499296298062586 no 1681 0.486407555069105 2502 6462800
SGTC_2572 astragaloside iv 100 µM -0.0344671565777762 0.499147686219082 no 1682 0.486252316016577 2581 45006101 An anti-inflammatory agent.
SGTC_459 nigericin 15.3 µM -0.035509352000498 0.498749894348439 no 1683 0.485836794630717 2503 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_789 1309-1135 70.6 µM -0.0359605039518935 0.498577696124187 no 1684 0.485656925925442 2480 3092424
SGTC_1655 st012546 55.1 µM -0.036743520937016 0.498278830427726 no 1685 0.485344753682872 2520 720985 YLR208W SEC13
SGTC_1826 st055655 41.6 µM -0.0369256128214839 0.498209328851998 no 1686 0.485272158795887 2508 676168
SGTC_2018 5133068 143 µM -0.0374891931354818 0.497994219564887 no 1687 0.48504747835981 2471 785362
SGTC_1734 st037168 69.4 µM -0.0379831502127055 0.497805684793468 no 1688 0.484850558257878 2540 708907
SGTC_3144 9087057 49.47 µM -0.0382079630864796 0.497719877813847 no 1689 0.484760935954286 2461 17249618
SGTC_2165 5727197 32.143 µM -0.0399024135475262 0.497073140604313 no 1690 0.484085463452282 2699 1361712
SGTC_3106 9121286 49.47 µM -0.0408915613983338 0.496695606474448 no 1691 0.483691172425416 2614 15943471
SGTC_3274 9138298 49.47 µM -0.0418595622345735 0.496326146518214 no 1692 0.483305326392891 2472 17015756
SGTC_1677 st019204 53.9 µM -0.0428665183224159 0.495941821735611 no 1693 0.482903969356637 2575 3945625
SGTC_125 0133-0007 11.75 µM -0.0440658122940879 0.495484092324993 no 1694 0.482425972068605 2521 26541
SGTC_2451 5856223 45.7 µM -0.0443090986125585 0.495391238980184 no 1695 0.48232900957753 2503 2179896
SGTC_219 mitoxanthrone 164.414 µM -0.04485751188578 0.495181930941826 no 1696 0.482110441666982 2537 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1041 0206-0046 107 µM -0.0454539442539575 0.494954297388223 no 1697 0.481872742044505 2583 50494
SGTC_1871 st057448 67.3 µM -0.0456944241374778 0.494862516628711 no 1698 0.481776904031388 2531 691747
SGTC_2357 9067248 200 µM -0.0465614115900234 0.494531627348489 no 1699 0.481431393872039 2520 9150235
SGTC_1150 3909-7983 10.9 µM -0.0465825012575459 0.494523578437229 no 1700 0.481422989431323 2496 23965914
SGTC_2959 9079155 11 µM -0.0474444150694637 0.494194629355226 no 1701 0.481079515374515 2571 16189457
SGTC_2346 9031566 143.75 µM -0.0484016085015316 0.493829321477892 no 1702 0.480698088705175 2549 4771086
SGTC_1032 k061-1018 98.7 µM -0.0487400769889754 0.49370014796892 no 1703 0.480563218497415 2664 4005393
SGTC_69 0096-0274 206.684 µM -0.0488627842387234 0.493653317993214 no 1704 0.480514323645581 2747 6741392
SGTC_421 streptovitacin 30 mM -0.0489607265529654 0.49361593936638 no 1705 0.480475297026195 2667 91467 include heat shock
SGTC_2181 6316240 54.2555 µM -0.0494573232440366 0.493426419470003 no 1706 0.480277423335299 2527 12779990
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0499178304826897 0.493250673985346 no 1707 0.480093934172943 2516 2374 Ca(2+)-ATPase inhibitor.
SGTC_2647 atorvastatin 60.16 µM -0.0513651148715749 0.492698348908626 no 1708 0.479517291180404 2548 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1078 idebenone 36.1 µM -0.0514093175120785 0.4926814801329 no 1709 0.479499680145814 2540 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_752 1896-0090 130 µM -0.0536205875189249 0.491837624398821 no 1710 0.478618726819296 2511 772567
SGTC_696 1560-0013 611 µM -0.0553466405033043 0.49117896037546 no 1711 0.477931152668183 2572 1650269
SGTC_1526 st051518 75 µM -0.0559270876626696 0.49095746631305 no 1712 0.477699945880837 2588 673993
SGTC_2595 hexamethylquercetagetin 100 µM -0.0561736529548294 0.490863379780174 no 1713 0.477601734954278 2558 386331
SGTC_2876 9059903 25.97 µM -0.0564297519178011 0.490765655844401 no 1714 0.477499728053355 2512 6916095
SGTC_386 1509-0011 3.07 µM -0.0565247603436312 0.490729402041667 no 1715 0.477461885576168 2511 3107280
SGTC_1996 st072960 66.8 µM -0.0567306890791049 0.490650822961209 no 1716 0.47737986351251 2480 1719405
SGTC_74 000s-0487 160.283 µM -0.0573403465736454 0.490418189643957 no 1717 0.477137040644009 2500 677548
SGTC_2878 9043973 25.97 µM -0.057345522706593 0.490416214547201 no 1718 0.477134979057981 2658 6465167
SGTC_1168 k815-0004 80.5 µM -0.0582275431379091 0.490079658716873 no 1719 0.476783690842487 2502 642433
SGTC_1427 4048-4900 550 nM -0.0585548953632441 0.489954751489942 no 1720 0.476653318643606 2547 24132586
SGTC_264 promethazine 12.5 mM -0.0594870303420679 0.489599083783236 no 1721 0.476282097735533 2501 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1513 0337-0559 19 µM -0.0595552193968907 0.489573065721588 no 1722 0.476254942383644 2539 775073
SGTC_1807 st050092 58.9 µM -0.0600319171654785 0.489391179243826 no 1723 0.476065107150263 2517 5008496
SGTC_456 gingerol 170 µM -0.0601111488540768 0.489360948199602 no 1724 0.476033555260034 2594 442793 A herb.
SGTC_2266 7929956 200 µM -0.0603752637212879 0.489260174969631 no 1725 0.475928379700074 2503 2967153
SGTC_1531 st059297 52.4 µM -0.0609063112202154 0.489057555471183 no 1726 0.475716911576405 2579 7566702
SGTC_605 1315-0399 119 µM -0.0621586608374332 0.488579736700643 no 1727 0.47521824133525 2587 24020461
SGTC_2210 7115885 190.385 µM -0.0642885534686644 0.487767140072977 no 1728 0.474370233804934 2525 2927039
SGTC_2120 5538279 151.968 µM -0.0647313485606831 0.487598211155577 no 1729 0.474193951307275 2543 2058197
SGTC_2521 angolensin 13.4 µM -0.0655465800751951 0.487287201406366 no 1730 0.473869410255257 2602 821428 A flavenoid.
SGTC_940 3232-1287 54.8 µM -0.0660418047530581 0.48709827760657 no 1731 0.47367227135199 2515 1585493 YIL048W NEO1
SGTC_536 3852-0578 10.6 µM -0.0663371272874007 0.486985616067854 no 1732 0.473554712504688 2582 2869208
SGTC_980 1473-0395 201 µM -0.0667622446691364 0.486823441382407 no 1733 0.473385490354132 2524 768876
SGTC_3207 9114163 49.47 µM -0.068131575193228 0.486301081201758 no 1734 0.472840447688571 2559 849233
SGTC_226 1,3-diallylurea 8.28947 mM -0.0681621509274132 0.486289417704177 no 1735 0.472828278026209 2611 74537 YKL182W FAS1
SGTC_3259 9138485 49.47 µM -0.0685218394143151 0.48615221089936 no 1736 0.47268511779657 2529 17646153
SGTC_3212 9128307 49.47 µM -0.0688952968593268 0.486009753521296 no 1737 0.472536481094165 2570 27243542
SGTC_316 k060-0003 58.6 µM -0.0695957991141301 0.485742547947327 no 1738 0.472257690328084 2644 6152314
SGTC_1437 4092-1038 11.6 µM -0.07196466584084 0.484838995284311 no 1739 0.471315013744009 2537 3977136
SGTC_1375 2910-0797 186 µM -0.0732117597064607 0.484363349449611 no 1740 0.470818804304826 2581 742508
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0732709619337351 0.484340770066958 no 1741 0.470795249296109 2522 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1386 3228-0095 33.8 µM -0.0738620115966579 0.484115349953078 no 1742 0.470560091800387 2596 870181
SGTC_546 peri-Naphthalide 147 µM -0.0750084335609681 0.483678131232958 no 1743 0.470104000893495 2613 223824 A penicillin ester.
SGTC_2634 4'-methoxyflavone 100 µM -0.0752829912800651 0.483573424186515 no 1744 0.469994777033955 2570 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_233 rapamycin 362 pM -0.0759556009193188 0.483316918375523 no 1745 0.469727210719634 2563 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_79 0052-0007 94.094 µM -0.0761797660078988 0.483231432506472 no 1746 0.469638040145259 2552 2801472
SGTC_2786 7743617 45.45 µM -0.0773873578758165 0.482770927946998 no 1747 0.469157698787846 2578 583674
SGTC_332 4112-0506 40.9 µM -0.0783692824687423 0.482396496536695 no 1748 0.468767153699154 2546 2790355
SGTC_2890 9046729 58.44 µM -0.0792728671978493 0.482051951706309 no 1749 0.468407793603956 2580 903329
SGTC_3218 9131285 49.47 µM -0.0804692498650551 0.481595781105203 no 1750 0.467932025978253 2572 17156417
SGTC_2173 5763948 167 µM -0.0809971101702601 0.481394520057265 no 1751 0.467722125352649 2552 2867177
SGTC_1892 st058411 7.36 µM -0.0815801930483083 0.481172209420876 no 1752 0.467490276221255 2560 3934738
SGTC_1488 4013-0813 75.9 µM -0.0819302742950197 0.481038737576585 no 1753 0.467351079977417 2541 2910057
SGTC_99 0109-0120 622.8 µM -0.082131375530768 0.480962066755421 no 1754 0.467271121667028 2558 759414
SGTC_1134 3477-0009 42.5 µM -0.0821573661276188 0.480952157765686 no 1755 0.467260787842694 2677 3973534
SGTC_1198 1612-1005 86.7 µM -0.0823151258871282 0.480892011656789 no 1756 0.467198063260448 2688 6998509
SGTC_1028 k015-0029 4.8 µM -0.0826048278667964 0.480781563542499 no 1757 0.467082881157747 2552 4588309
SGTC_924 2046-0044 21.3 µM -0.0826938681116988 0.480747617480402 no 1758 0.467047480356056 2546 3623589
SGTC_708 3448-5400 146 µM -0.0836218504817953 0.480393838094364 no 1759 0.466678546804313 2551 3462195
SGTC_271 rotenone 740 µM -0.0843173834731197 0.480128686663541 no 1760 0.466402045802504 2687 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2917 7979103 53.79 µM -0.0843323253775159 0.48012299059941 no 1761 0.466396106000694 2631 2980565
SGTC_2110 5483698 200 µM -0.0843377050617205 0.480120939789113 no 1762 0.466393967435907 2609 2848765 YHR062C RPP1
SGTC_1503 4585-0012 61.3 µM -0.0855345648663196 0.479664693397765 no 1763 0.465918208680007 2734 2922052
SGTC_1408 3909-7976 48.8 µM -0.0865285594741733 0.479285800026426 no 1764 0.465523127013953 2582 24152374
SGTC_496 calpeptin 138 µM -0.0867581664263705 0.479198280518043 no 1765 0.465431870272193 2641 73364 A calpain inhibitor.
SGTC_2229 7354935 190 µM -0.0871398645541004 0.479052790487836 no 1766 0.465280169276518 2562 318112
SGTC_1024 4507-0395 26 µM -0.0871829393521048 0.479036372050203 no 1767 0.465263050070286 2708 4201836
SGTC_218 alverine citrate 93.75 µM -0.0871984121410442 0.479030474433545 no 1768 0.465256900739327 2656 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_130 0136-0219 337.655 µM -0.0875302459490487 0.478903993585774 no 1769 0.465125022447646 2527 234244
SGTC_3328 9140624 29.0385 µM -0.0888764132899958 0.478390914123257 no 1770 0.464590064412253 2592 4904392
SGTC_949 1165-0505 146 µM -0.0889393289005371 0.47836693527874 no 1771 0.464565063720989 2563 6244267
SGTC_372 0155-0182 15.9 µM -0.0893101952347769 0.478225589660512 no 1772 0.464417695912232 2564 771486
SGTC_2756 carbadox 75.1 µM -0.0895172516694612 0.478146676921188 no 1773 0.464335421887131 2597 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3041 9091929 49.47 µM -0.0905170425492925 0.477765651673628 no 1774 0.463938175774749 2647 25236887
SGTC_953 1188-0045 9.7 µM -0.0922590976760692 0.47710179461335 no 1775 0.463246092523042 2664 6144426
SGTC_1339 1486-1321 22.7 µM -0.0933253808774461 0.476695489890474 no 1776 0.462822534523847 2590 3469382
SGTC_144 4161-2749 112.381 µM -0.0937623959158834 0.476528973306343 no 1777 0.46264895187698 2562 797501 YMR168C CEP3
SGTC_1245 0418-0076 17.2 µM -0.0952770998039808 0.47595185501019 no 1778 0.462047365801761 2709 6790114
SGTC_366 0181-0206 4.31 µM -0.0954072933263695 0.475902252230105 no 1779 0.461995661634849 2608 274874
SGTC_2461 5755302 26.15 µM -0.0958514731250389 0.475733025789581 no 1780 0.46181926793962 2704 2788904
SGTC_2544 sphondin 68.51 µM -0.0964980399942477 0.475486700469075 no 1781 0.461562515260589 2777 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2241 6772625 37.8075 µM -0.0966667635012411 0.475422422697086 no 1782 0.461495517532661 2550 2285411
SGTC_985 1493-0307 8.71 µM -0.0975566319244859 0.475083424484041 no 1783 0.461142181440665 2610 3278274
SGTC_1875 nocodazole 6 µM -0.0981023401924521 0.474875544086129 no 1784 0.460925514643715 2558 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_280 3448-3607 3.04 µM -0.0997509329508888 0.474247576099624 no 1785 0.460271031752832 2584 626179
SGTC_1327 1436-0082 2.18 µM -0.100737836899282 0.473871683522978 no 1786 0.4598792873176 2641 15992205
SGTC_251 melphalan 456.522 µM -0.100959457331868 0.473787275784157 no 1787 0.459791322019635 2638 460612 A DNA alkylator.
SGTC_1043 0916-0009 19.3 µM -0.100976372275908 0.473780833501466 no 1788 0.459784608242521 2566 3101130
SGTC_2580 diallyl disulphide 81.36 µM -0.101937872477911 0.473414644612735 no 1789 0.459402994317539 2637 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3331 9141060 1.957 µM -0.103419016396144 0.472850592649273 no 1790 0.458815210083989 2598 4906567 YPR165W RHO1
SGTC_763 3453-1109 128 µM -0.103714379910015 0.472738118244204 no 1791 0.458698007341041 2580 1560353
SGTC_1792 st045773 43.6 µM -0.104674140212993 0.472372656642405 no 1792 0.458317191167022 2597 2919270
SGTC_2026 5148700 152 µM -0.105880307863864 0.471913400022865 no 1793 0.457838659139648 2593 79838
SGTC_1226 3909-7979 35.4 µM -0.106475285912188 0.471686871758529 no 1794 0.457602631456121 2702 6615510
SGTC_2006 4011487 200 µM -0.107464503873775 0.471310263335574 no 1795 0.457210242006531 2677 45595294
SGTC_161 4065-0411 162.148 µM -0.108693289356558 0.470842484137314 no 1796 0.456722882318857 2706 1906281 YLR208W SEC13
SGTC_1727 st034309 9.9045 µM -0.108727200492504 0.470829575271663 no 1797 0.456709433437092 2907 870305
SGTC_3006 9075424 71.4286 µM -0.108793173792809 0.470804461471494 no 1798 0.4566832691028 2608 7465181
SGTC_3017 9080681 49.47 µM -0.11139083705912 0.469815712381734 no 1799 0.455653212905332 2668 16451914
SGTC_2519 cryptotanshinone 88.04 µM -0.111949182678697 0.469603213266453 no 1800 0.45543184976565 2636 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1351 1496-0003 46.5 µM -0.112999402096927 0.469203536855344 no 1801 0.455015514618015 2683 3891978
SGTC_1909 st060837 51.5 µM -0.113685936825069 0.468942282737651 no 1802 0.454743380512923 2659 678937
SGTC_86 0417-1630 471.922 µM -0.114006195042439 0.468820416153129 no 1803 0.454616441266308 2602 3634867
SGTC_1579 chlormadinone acetate 49.4 µM -0.114111336119051 0.468780407874223 no 1804 0.454574768001126 2731 45114258 A steroidal progestin.
SGTC_2016 5121758 140 µM -0.114561905146008 0.468608960938742 no 1805 0.454396188066263 2593 2795203
SGTC_1991 st073000 8.92 µM -0.116548125380317 0.467853250065981 no 1806 0.453609073701121 2808 4301969 YIL048W NEO1
SGTC_500 h-89 112 µM -0.116866257689132 0.467732218770589 no 1807 0.453483018673337 2780 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1818 st052136 56.3 µM -0.119836503135878 0.466602354310778 no 1808 0.452306332486963 2656 674169
SGTC_2483 5729050 27.16 µM -0.12107616351499 0.466130873625461 no 1809 0.451815354510249 2666 2865180
SGTC_1977 st070720 65.3 µM -0.122005116851192 0.465777595430494 no 1810 0.451447482943014 2729 682188
SGTC_3142 9086498 49.47 µM -0.122048384476923 0.465761141536038 no 1811 0.451430349695335 2682 25236367
SGTC_67 0335-0847 266 µM -0.122539155125506 0.465574514450374 no 1812 0.451236019163491 3008 4552207 YOR254C SEC63
SGTC_320 4092-0846 5.34 µM -0.122748956772442 0.465494734745752 no 1813 0.451152947535065 2714 1359356
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.1229778598114 0.465407693079561 no 1814 0.451062315090265 2613 442882
SGTC_1380 2291-0730 164 µM -0.123133903933208 0.465348357374218 no 1815 0.451000532050451 2691 2999191
SGTC_2299 7976368 114.88 µM -0.12589098715402 0.464300106012411 no 1816 0.449909108561608 2714 2979718
SGTC_2929 9013348 24.6 µM -0.126279927444981 0.464152249512732 no 1817 0.449755172315947 2708 2995952
SGTC_373 0844-0104 25.9 µM -0.12707817786118 0.463848808405336 no 1818 0.449439261482079 2703 5375804
SGTC_2377 9073351 62.6 µM -0.127564325539971 0.46366401805437 no 1819 0.449246882257872 2626 7337946 YHR072W ERG7
SGTC_475 α-linolenic acid 10 µM -0.127621219913199 0.463642392357224 no 1820 0.449224368694226 2847 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2481 5478948 45.16 µM -0.129710982099821 0.462848143357601 no 1821 0.448397546759392 2755 77792
SGTC_319 1348-1596 45.5 µM -0.131034784672311 0.462345086510993 no 1822 0.447873895220182 2811 5380505
SGTC_10 0279-0212 42.575 µM -0.131192830641996 0.46228503163402 no 1823 0.447811383629618 2663 39851 YBR002C RER2
SGTC_15 0266-0086 27.098 µM -0.131462542725725 0.462182547451009 no 1824 0.447704707969557 2667 1712902 YIL048W NEO1
SGTC_588 3970-1144 52.9 µM -0.13214082742047 0.461924826495417 no 1825 0.447436451711771 2786 1888707
SGTC_742 0kpi-0133 140 µM -0.132530513420604 0.461776768682 no 1826 0.447282344832533 2769 2728852
SGTC_1956 st077085 54 µM -0.132982735690995 0.461604957396996 no 1827 0.447103517072998 2681 24208685
SGTC_1643 st009866 20.2 µM -0.133452406023601 0.461426524714123 no 1828 0.446917800998589 2669 3156273 YOR207C RET1
SGTC_643 k048-0106 28.4 µM -0.133690731175001 0.461335985458118 no 1829 0.446823567407987 2759 6763920
SGTC_2460 5552655 174.22 µM -0.133757792426494 0.461310509381716 no 1830 0.446797051979234 2756 5401989
SGTC_882 0843-0131 351 µM -0.135238306950205 0.460748113429283 no 1831 0.446211730360409 2626 5425421
SGTC_520 3584-0023 682 µM -0.135293442520484 0.460727170853831 no 1832 0.446189934760623 2731 1340790
SGTC_64 000l-0018 272.079 µM -0.136000733014921 0.460458524847927 no 1833 0.445910350743642 2644 6811119
SGTC_1088 bifonazole 369 nM -0.136103149425968 0.460419626115348 no 1834 0.44586986890824 2616 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_724 3910-0327 137 µM -0.138502803713133 0.459508323663168 no 1835 0.444921526965183 2694 2885483
SGTC_1573 oleylamine 1.06 µM -0.139939541832488 0.458962803656113 no 1836 0.444353879399482 2633 5356789 An amine of the fatty acid oleic acid.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.140582130369454 0.458718841964465 no 1837 0.444100032962124 2619 5355888
SGTC_1139 k015-0024 46.9 µM -0.140995574255028 0.458561884306923 no 1838 0.443936719324594 2634 2766652
SGTC_2694 st077685 81.9 µM -0.141138596646111 0.458507589542958 no 1839 0.44388022655243 2649 2838096
SGTC_825 1988-2224 89.6 µM -0.141672937912258 0.458304747512174 no 1840 0.443669175856509 2666 1180859
SGTC_3053 9095903 49.47 µM -0.141734440957487 0.45828140095147 no 1841 0.443644884801199 2655 17174018
SGTC_2402 5553605 200 µM -0.143284008969222 0.457693232520941 no 1842 0.443032942255737 2817 6758546
SGTC_1701 st028638 40.4 µM -0.14375773700585 0.457513438336933 no 1843 0.442845888557536 2680 3490878
SGTC_2328 6201408 200 µM -0.144264270328929 0.457321203169628 no 1844 0.442645895633892 2747 2890418
SGTC_2352 9027995 87.8 µM -0.14518656868593 0.456971206109189 no 1845 0.442281785103163 2727 2997347
SGTC_61 0978-8327 98.565 µM -0.145480137386636 0.456859808603929 no 1846 0.442165898488027 2653 6150059 YHR072W ERG7
SGTC_2296 7971656 126.45 µM -0.145542769483447 0.45683604268272 no 1847 0.442141175029016 2728 666570
SGTC_207 4185-0010 4.486 µM -0.146958334622972 0.456298943939736 no 1848 0.441582453664552 2677 3761753
SGTC_811 0416-0114 265 µM -0.147556563862477 0.456071985624003 no 1849 0.441346368383964 2752 6612453
SGTC_608 k048-0125 159 µM -0.148617330086002 0.45566958368272 no 1850 0.440927798724102 2739 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2507 purpurin 79.67 µM -0.14924545686198 0.455431325036467 no 1851 0.440679976118701 2663 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3110 9122132 49.47 µM -0.149441679333994 0.455356897960687 no 1852 0.44060256280392 2814 918317
SGTC_1203 3992-3522 103 µM -0.14951201270663 0.45533022093243 no 1853 0.440574815568618 3002 5322312
SGTC_2620 irigenin 100 µM -0.150211641404859 0.455064866931429 no 1854 0.440298820795802 2807 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_183 3914-0051 30.55 µM -0.150532334702977 0.454943241608217 no 1855 0.440172320986076 2756 1596232
SGTC_1950 st077106 7.18 µM -0.151387389918428 0.454618976219645 no 1856 0.439835068103166 2762 13831864
SGTC_2947 9072639 7.68 µM -0.152402272430825 0.454234138265879 no 1857 0.439434832437236 2737 16488146
SGTC_411 enrofloxacin 100 µM -0.154805683554874 0.45332294976065 no 1858 0.43848725520077 2819 71188 A bacterial gyrase inhibitor.
SGTC_123 0083-0120 66.675 µM -0.155403770850045 0.453096239083974 no 1859 0.438251505786754 2688 16001701
SGTC_453 enantio-paf c16 10 µM -0.156240479272862 0.452779102468399 no 1860 0.437921735331936 2753 13871343 A lipid and platelet activating factor
SGTC_17 0960-0276 49.807 µM -0.156879697824644 0.452536840491595 no 1861 0.437669830255183 2682 6821114
SGTC_2031 5180455 200 µM -0.15755545594384 0.45228074933859 no 1862 0.437403553030223 2682 29949
SGTC_2635 hydroquinidine 100 µM -0.157687533775287 0.452230698294847 no 1863 0.437351512097365 2691 442912 An experimental heart treatment.
SGTC_11 0438-0307 1.3 µM -0.158325251230474 0.451989045238933 no 1864 0.437100255739175 2788 4011476
SGTC_1480 1070-0044 41.2 µM -0.159268772982318 0.451631545078323 no 1865 0.436728561118836 2780 3124987
SGTC_2306 7482397 179.52 µM -0.159524168665081 0.451534782449851 no 1866 0.436627959144174 2813 891448
SGTC_1707 st032323 6.317 µM -0.159703097480148 0.451466992797844 no 1867 0.436557480393527 2694 3132057 YMR211W DML1
SGTC_2908 7930301 100 µM -0.159704352800402 0.451466517207431 no 1868 0.436556985939179 2687 2223178
SGTC_2581 avocatin a 64 µM -0.159727659024142 0.451457687428215 no 1869 0.436547805938269 2752 6710728 A skin care supplement.
SGTC_545 4218-0007 221 µM -0.160386407684864 0.451208124331959 no 1870 0.436288348055229 2783 2840508
SGTC_2189 6047310 154.431 µM -0.16040216036724 0.451202156755619 no 1871 0.436282143963914 2670 711535
SGTC_626 0214-0009 33 µM -0.162181462001163 0.450528176607111 no 1872 0.435581478854705 2800 3437874
SGTC_1604 st002052 72.4 µM -0.162629898834623 0.450358336029294 no 1873 0.435404922257655 2814 6254834 YHR062C RPP1
SGTC_2415 st077333 57.7 µM -0.16287648923839 0.450264946465221 no 1874 0.435307841242368 2816 2766255
SGTC_3150 9097574 49.47 µM -0.162892980555915 0.450258700915035 no 1875 0.435301348858481 2781 17217476
SGTC_968 1309-0633 340 µM -0.16315105004705 0.45016096709381 no 1876 0.435199753050985 2760 3761976
SGTC_3185 9108267 49.47 µM -0.16340315501339 0.450065495023747 no 1877 0.435100509465064 2762 4910486
SGTC_966 1300-0360 30.2 µM -0.164064957281855 0.449814884481023 no 1878 0.434840003996989 2706 70588
SGTC_1803 st050068 52.4 µM -0.166814688367807 0.448773834829506 no 1879 0.433757930491599 2695 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2423 st077119 87.2 µM -0.166826522956492 0.448769355004871 no 1880 0.433753274413902 2635 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_633 0437-0093 97.7 µM -0.166861709356554 0.448756035704183 no 1881 0.43373943109629 2681 2831118
SGTC_1571 st070080 73.4 µM -0.167173591295322 0.448637979852523 no 1882 0.433616731540685 2838 4315245
SGTC_1191 1487-1166 10.6 µM -0.167901246050721 0.448362560308898 no 1883 0.433330484919624 2816 3955771
SGTC_155 k072-0202 43.6 µM -0.16877315344115 0.448032573490961 no 1884 0.432987537910034 2665 5857737
SGTC_2121 5257820 149.641 µM -0.169852075404758 0.447624288613048 no 1885 0.432563235819701 2825 791256
SGTC_2650 prasterone 100 µM -0.169920703926692 0.447598320129331 no 1886 0.432536249258904 2704 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_54 0159-0055 9 µM -0.170413055235168 0.447412024925301 no 1887 0.432342652859444 2916 3319099
SGTC_1369 1866-0067 208 µM -0.170952033710304 0.447208100301384 no 1888 0.432130740916513 2756 3531355
SGTC_3352 9151559 45.5865 µM -0.171112255069346 0.447147482609155 no 1889 0.432067749918868 2798 17159339
SGTC_2905 7799065 20.05 µM -0.171378477867999 0.447046763365251 no 1890 0.431963088294288 2828 1296806
SGTC_2338 7999974 200 µM -0.171488380816501 0.447005185119936 no 1891 0.431919882939286 2813 315925
SGTC_136 0097-0015 404.482 µM -0.173144245844073 0.446378812606904 no 1892 0.431269023485202 2670 4861337
SGTC_2380 9035439 200 µM -0.173624152377863 0.446197300847736 no 1893 0.431080424727938 2848 6462575
SGTC_519 k048-0011 62.8 µM -0.173836424030628 0.4461170183892 no 1894 0.430997008973486 2836 6836379
SGTC_2313 7726885 200 µM -0.174592388456757 0.44583112590758 no 1895 0.430699964926629 2821 726423
SGTC_3100 9120536 49.47 µM -0.175341012445009 0.445548037203332 no 1896 0.43040584381991 2662 16421196
SGTC_3276 9139060 49.47 µM -0.176322906649568 0.445176780549251 no 1897 0.430020133524847 2702 4870619
SGTC_284 0988-0104 32.6 µM -0.176519653373145 0.445102395892629 no 1898 0.429942854971843 2818 4666532
SGTC_3297 9117502 71.43 µM -0.176914657290415 0.444953061349576 no 1899 0.42978771268647 2704 7453720
SGTC_1119 parthenolide 318.541 nM -0.177577657889402 0.444702425984503 no 1900 0.429527336034927 2917 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2804 7954240 19.48 µM -0.177631432456486 0.444682098451546 no 1901 0.429506218781506 2865 828705
SGTC_823 0417-1665 178 µM -0.178595432705245 0.444317717704668 no 1902 0.429127690502089 2820 3429856
SGTC_1003 4049-0218 100 µM -0.178856548834948 0.444219026967921 no 1903 0.429025170776594 2881 295161
SGTC_1685 st024049 53.0905 µM -0.180760429491279 0.443499546379589 no 1904 0.428277812039338 2812 1941139
SGTC_2910 7948405 25.97 µM -0.181686711602084 0.443149569572145 no 1905 0.42791429750358 2828 2971328
SGTC_1624 st003710 6.25 µM -0.181951899124746 0.443049382027781 no 1906 0.427810237307258 2904 24207033
SGTC_2814 7977482 42.97 µM -0.182010427149702 0.443027270696795 no 1907 0.427787271451208 2881 6456762
SGTC_2322 7413319 38.22 µM -0.182540344935219 0.442827080883011 no 1908 0.427579347754395 2856 1840400
SGTC_2445 5742597 35.57 µM -0.182874516097584 0.442700846795721 no 1909 0.427448239443331 2742 1774255
SGTC_2060 5238662 140 µM -0.183271272814085 0.442550978394806 no 1910 0.427292586795813 2835 790130
SGTC_710 3448-4187 58 µM -0.183703692078137 0.442387648409076 no 1911 0.427122956172781 2746 3946412
SGTC_2888 9058547 12.99 µM -0.184262814318998 0.44217647569696 no 1912 0.426903642135584 2750 16476514
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.184352314050255 0.442142674414331 no 1913 0.426868538228054 3080 5282309
SGTC_1729 st035615 45.989 µM -0.184378311089215 0.442132856215057 no 1914 0.42685834168417 2858 17385451
SGTC_2192 5915882 198.485 µM -0.185028968684733 0.441887136518509 no 1915 0.426603157067702 2735 2876149
SGTC_2070 5230947 200 µM -0.185393913131978 0.441749325671894 no 1916 0.426460041142845 2810 2835538
SGTC_3229 9132204 49.47 µM -0.187284109546454 0.441035660185265 no 1917 0.425718940649108 2720 17682924
SGTC_23 0213-0011 39.996 µM -0.188858544573174 0.440441360093711 no 1918 0.425101842720389 2875 627608
SGTC_1412 3909-8563 178 µM -0.189162869716587 0.440326502276985 no 1919 0.424982583956367 2822 23767530
SGTC_1957 st077035 62.4 µM -0.189378071315365 0.440245284329027 no 1920 0.424898255019478 2756 705593
SGTC_2847 9005661 71.43 µM -0.189850039021353 0.440067170628515 no 1921 0.42471332170892 2728 2991449
SGTC_1133 3473-0247 50 µM -0.189892766586517 0.440051046469295 no 1922 0.424696580384851 2821 711311
SGTC_1632 st005650 90 µM -0.190710805733582 0.439742361131457 no 1923 0.424376086163042 2873 2759605
SGTC_1523 st012844 44.7 µM -0.192920278121291 0.438908805005686 no 1924 0.423510701853091 2874 4274103
SGTC_6 0844-0013 19.835 µM -0.194107809399711 0.43846090294948 no 1925 0.423045733454641 2785 1584900
SGTC_2851 9015922 71.43 µM -0.195161904743478 0.438063395027887 no 1926 0.42263310059312 2932 2996893
SGTC_3107 9121808 49.47 µM -0.196463315707559 0.437572708615254 no 1927 0.422123771466572 2739 662681
SGTC_732 3970-1727 52.7 µM -0.198335199675062 0.436867098516194 no 1928 0.421391406655962 2874 1275699
SGTC_986 1493-0483 84 µM -0.198712711775204 0.436724818896644 no 1929 0.421243739882865 2776 40079
SGTC_227 fluconazole 33.516 µM -0.19909474169881 0.436580844898101 no 1930 0.421094317204975 2778 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1313 1220-0047 237 µM -0.200689137978943 0.435980062434362 no 1931 0.420470826780619 2807 3528706
SGTC_3233 9132340 49.47 µM -0.201302437839583 0.435749004938827 no 1932 0.420231048231883 2784 17682950
SGTC_1124 fisetin 1.16336 µM -0.201994163533316 0.435488427242568 no 1933 0.419960643482101 2833 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2936 9038235 15.59 µM -0.202582265727931 0.435266907235836 no 1934 0.419730776242016 2745 4749415
SGTC_2407 paclitaxel 400 µM -0.202751725124538 0.435203080860568 no 1935 0.41966454595539 3000 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1392 3455-1037 33.9 µM -0.203185874272405 0.435039567588422 no 1936 0.419494876625225 2904 981132
SGTC_1029 k015-0030 64.7 µM -0.205036221857167 0.434342797443421 no 1937 0.418771912606571 2882 2208316
SGTC_585 0kpi-0023 191 µM -0.206328472293551 0.433856306143867 no 1938 0.418267169657482 2905 64601
SGTC_2279 7948423 32.93 µM -0.207389492955131 0.433456940378908 no 1939 0.417852843818619 2938 1247112
SGTC_3138 9097216 49.47 µM -0.210141194783462 0.432421523601505 no 1940 0.416778737217215 2713 25237486
SGTC_2109 5483026 200 µM -0.210913222545697 0.432131106227553 no 1941 0.416477493056503 2814 759335
SGTC_2477 5967686 25.23 µM -0.211000869987875 0.432098137785164 no 1942 0.416443296243335 2767 776118
SGTC_2568 diosmetin 100 µM -0.211416765515245 0.431941705809956 no 1943 0.416281037706396 2865 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1219 1469-0211 33.1 µM -0.211670341864116 0.431846332646824 no 1944 0.416182113785061 2881 6822282
SGTC_2697 mebhydrolin 72.4 µM -0.211801046276277 0.431797174671456 no 1945 0.416131126114896 2911 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1345 1488-0192 31.4 µM -0.21185367034999 0.431777383036987 no 1946 0.416110597910966 2883 658348
SGTC_2526 patulin 37.61 µM -0.211983116089207 0.431728699911156 no 1947 0.416060103202165 2920 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_935 2996-0153 430 µM -0.212163319888434 0.431660928961069 no 1948 0.415989810894664 2943 23738523
SGTC_1929 genistein trimethyl ether 50.5 µM -0.212947846220724 0.431365908175714 no 1949 0.415683821133338 2939 136420
SGTC_2853 9015042 58.44 µM -0.21419801689975 0.430895861214805 no 1950 0.415196321240659 2741 6457456
SGTC_3194 9111903 49.47 µM -0.214423332171277 0.430811156165152 no 1951 0.415108474161996 2971 17087251
SGTC_3151 9099821 49.47 µM -0.217796538837052 0.42954341508935 no 1952 0.413793820721515 2922 17174189
SGTC_2309 7664088 163.95 µM -0.218104823249658 0.429427589603222 no 1953 0.413673719729642 2920 704922
SGTC_1679 SEC14.276 6.7 µM -0.218818405154792 0.429159513184405 no 1954 0.413395754527991 2948 1005053 YMR079W SEC14
SGTC_902 1120-0002 2.07 µM -0.219515407977346 0.428897696687359 no 1955 0.41312428935866 2774 3280475
SGTC_3323 9138564 53.9225 µM -0.220142923655752 0.428662008534957 no 1956 0.412879923218176 2941 43912313 YNL103W MET4
SGTC_41 0478-0632 82.643 µM -0.220466260901507 0.428540576461833 no 1957 0.41275402292257 2803 3750424
SGTC_1552 6-methylflavone 10.6 µM -0.221281377086799 0.428234482642948 no 1958 0.412436674758602 2805 689013
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.221472782066521 0.428162612171322 no 1959 0.412362163587956 2928 688662
SGTC_32 0928-0142 34.1 µM -0.222825092642965 0.427654902399358 no 1960 0.411835818917221 2825 2244242
SGTC_1294 1000-1494 117 µM -0.223334267572098 0.427463769401141 no 1961 0.411637679519006 2818 712797 YDL207W GLE1
SGTC_706 4262-0057 46.9 µM -0.223464787064718 0.427414778011904 no 1962 0.411586893028918 2805 883298
SGTC_1971 st069429 63.5 µM -0.223923417232044 0.427242636905857 no 1963 0.411408447020359 2949 1246522 YGL099W LSG1
SGTC_3024 9090631 49.47 µM -0.224109569716418 0.427172770845972 no 1964 0.411336023152106 2858 25236383
SGTC_635 k038-0028 24.7 µM -0.225481864437894 0.426657796910157 no 1965 0.410802216108619 2844 4035102
SGTC_2253 7938677 135.83 µM -0.226667138433778 0.426213105845731 no 1966 0.410341290888209 3008 2301972
SGTC_2849 9019321 12.99 µM -0.227980012816518 0.425720651184147 no 1967 0.409830889428246 2940 16489627
SGTC_3043 9092303 49.47 µM -0.228835099860397 0.425399973219864 no 1968 0.409498542395787 2823 25236084
SGTC_1712 st032288 53.4 µM -0.229339631238182 0.425210785095098 no 1969 0.409302476465853 2866 2883011
SGTC_2406 ethylparaben 405.7 µM -0.229964889118678 0.424976351097639 no 1970 0.409059526494122 2764 8434 A possible steroid mimic.
SGTC_129 0088-0017 176.636 µM -0.230363966787609 0.42482673490408 no 1971 0.408904479278805 2911 182446
SGTC_961 1252-1571 372 µM -0.230797766063418 0.424664113691549 no 1972 0.408735958405319 2974 6813498
SGTC_2010 4012422 159 µM -0.231850946671929 0.424269354294387 no 1973 0.408326892631373 2896 952393
SGTC_50 0929-0078 56.389 µM -0.234352984600004 0.423331830907205 no 1974 0.407355477596862 2847 1377751
SGTC_1268 0828-0275 2.46 µM -0.234528593056886 0.42326604596731 no 1975 0.40728731901585 2924 745337
SGTC_1359 1582-0056 520 nM -0.236526672829274 0.422517693465834 no 1976 0.406512006215508 2929 3661189
SGTC_397 arbidol 50 µM -0.237566840377633 0.422128223916502 no 1977 0.406108535896893 2971 131410 A RNA synthesis inhibitor.
SGTC_2149 5554786 194.827 µM -0.238293092078762 0.421856338876357 no 1978 0.405826889390228 2841 745063 YPR165W RHO1
SGTC_2857 9024691 58.44 µM -0.238937223240387 0.421615228257265 no 1979 0.405577130696599 2936 16478292
SGTC_2945 9067681 61.76 µM -0.23906256762959 0.421568312866505 no 1980 0.40552853348991 2766 16456930
SGTC_2226 7298446 200 µM -0.239939989713539 0.421239932089539 no 1981 0.405188389453809 2935 3283010
SGTC_2994 9053520 71.4286 µM -0.243708053797327 0.419830335720056 no 1982 0.403728467694178 2983 4647384
SGTC_2874 9043904 71.43 µM -0.244015355551825 0.419715422194107 no 1983 0.403609463662034 2907 4463428
SGTC_817 1391-0715 46 µM -0.244674822021413 0.419468842045254 no 1984 0.403354112343364 2882 1353946
SGTC_1074 carmofur 3.8 µM -0.244994945077885 0.419349156692757 no 1985 0.403230172678189 2848 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_750 4073-0104 132 µM -0.246306462615009 0.418858893779325 no 1986 0.402722503791949 2919 22330957
SGTC_398 bronopol 33.3 µM -0.246820904041464 0.418666623006426 no 1987 0.402523415912067 2810 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_262 fenpropimorph 62.5 µM -0.246937730578554 0.418622962181921 no 1988 0.402478207778659 2822 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2155 5570423 76 µM -0.247140150675075 0.418547315404701 no 1989 0.402399880763107 2857 797402
SGTC_1438 4092-1045 4 µM -0.247166445773086 0.418537488837478 no 1990 0.402389706089786 2845 1351342
SGTC_489 paxilline 115 µM -0.247855060093404 0.418280169448146 no 1991 0.402123275966198 2904 105008 A toxic potassium channel blocker.
SGTC_3128 9127691 49.47 µM -0.248554132328555 0.418018977947819 no 1992 0.401852846106893 2988 41316314
SGTC_338 4055-0136 114 µM -0.248653393454648 0.417981894347737 no 1993 0.401814451632012 2848 2900563
SGTC_2555 cholic acid 100 µM -0.249454647315815 0.417682575512229 no 1994 0.401504559177512 3006 6708657 Influences liver metabolism.
SGTC_301 4119-0100 24.5 µM -0.250054151327776 0.417458654141742 no 1995 0.401272735866884 2871 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3173 9105693 49.47 µM -0.252833596957558 0.416420851301827 no 1996 0.400198402174465 3018 17096658
SGTC_1389 3405-0187 19 µM -0.252982095315416 0.4163654205918 no 1997 0.400141024563371 2895 799890
SGTC_2563 tomatine 8.54 µM -0.254799025506483 0.415687341149343 no 1998 0.399439163985311 2945 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2282 7944268 200 µM -0.254928728397816 0.415638945525597 no 1999 0.399389073551307 3063 2970414
SGTC_1850 st056238 17 µM -0.255109150156086 0.4155716274618 no 2000 0.399319398567049 2816 5393177
SGTC_95 0471-0001 561.058 µM -0.255661163571093 0.41536567837424 no 2001 0.399106242839403 2875 4015405
SGTC_2778 tioconazole 65.09 nM -0.25687145978239 0.414914213908944 no 2002 0.398639001640656 2811 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1259 0671-0132 43 µM -0.256877347709714 0.414912017869524 no 2003 0.398636728929921 2880 X1259
SGTC_3217 9129673 49.47 µM -0.257076559135536 0.414837718902813 no 2004 0.398559836333997 3035 17248312
SGTC_326 k292-0812 17.5 µM -0.257873335939343 0.414540579216384 no 2005 0.398252331944494 2939 3579357
SGTC_2478 5763493 32.33 µM -0.258172932267931 0.414428864257876 no 2006 0.39813672344349 2851 1365576 YLR208W SEC13
SGTC_2131 toluylene red 5.2905 µM -0.258575995537886 0.414278578957264 no 2007 0.397981203134783 2900 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2437 5741531 144.16 µM -0.258982063943007 0.41412718585888 no 2008 0.397824539696645 3048 2262990
SGTC_634 1611-4317 11.2 µM -0.259156231275801 0.414062255554943 no 2009 0.397757350022725 2858 2843522
SGTC_1059 3448-6867 171 µM -0.259378763009683 0.413979298219922 no 2010 0.397671506909712 2828 3934407
SGTC_2471 5466956 24.79 µM -0.262018429184463 0.412995554058606 no 2011 0.396653616991008 2878 724419
SGTC_1008 4106-0037 6 µM -0.26325663367304 0.412534290896821 no 2012 0.396176391175317 2819 2905394
SGTC_530 4358-1714 28 µM -0.263557049522228 0.412422396412459 no 2013 0.396060629036325 2965 1564641
SGTC_3133 9127736 49.47 µM -0.263837656183987 0.412317886592257 no 2014 0.395952508441242 2964 27243420
SGTC_2997 9067075 71.4286 µM -0.263978223990897 0.412265535516871 no 2015 0.395898349247092 2973 27209819
SGTC_830 4076-0286 57.8 µM -0.264032275737552 0.412245405668348 no 2016 0.395877524252262 2873 6866659
SGTC_793 0488-0545 106 µM -0.264584004966668 0.412039944934083 no 2017 0.395664971658577 2861 292548
SGTC_1877 wortmannin 25 µM -0.264771781717852 0.411970023467564 no 2018 0.395592638110381 3007 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2837 9008476 45.46 µM -0.265476846440828 0.411707507094842 no 2019 0.395321072002552 3069 2992805
SGTC_2049 5262831 67.185 µM -0.267080218721384 0.411110671630146 no 2020 0.394703698863627 2943 763417
SGTC_1836 st055642 81 µM -0.269274199283894 0.410294323095293 no 2021 0.393859342570009 2893 8571
SGTC_1171 0368-0077 21.4 µM -0.26961538790958 0.410167406548929 no 2022 0.393728080390588 2880 3239779
SGTC_1689 st020265 53.493 µM -0.271874176618407 0.409327412314412 no 2023 0.392859383831502 3020 5758320 YPR016C TIF6
SGTC_1207 2099-0101 141 µM -0.271888793797223 0.409321977855609 no 2024 0.392853764014148 2991 5837381
SGTC_562 3772-2733 112 µM -0.271977798797706 0.409288887440808 no 2025 0.392819545044409 3001 2876874 YIL048W NEO1
SGTC_743 1275-0778 158 µM -0.272568337621741 0.409069352397666 no 2026 0.392592526768986 2993 2849257 YMR203W TOM40
SGTC_432 NS 1619 61.3 µM -0.273247492999944 0.40881690907879 no 2027 0.3923314871953 3055 4552 A K+/calcium channel activator.
SGTC_538 2922-0838 53.3 µM -0.273281817155382 0.408804151729484 no 2028 0.392318295677563 3090 777039
SGTC_2960 9079389 5.97 µM -0.273581307500733 0.408692843464365 no 2029 0.39220320029078 3053 16457355
SGTC_3306 9127676 59.7925 µM -0.273593148584408 0.408688442771008 no 2030 0.392198649906744 2974 41905287
SGTC_200 k038-0079 37.545 µM -0.273857087664778 0.408590353812854 no 2031 0.392097225164848 2900 3436683
SGTC_3049 9092223 49.47 µM -0.274501109726144 0.408351036819683 no 2032 0.391849775461137 2984 8623917
SGTC_113 0099-0221 2.5 µM -0.276119068733039 0.407749958260898 no 2033 0.391228307533405 3084 89219
SGTC_1346 1488-2224 62.4 µM -0.278949616539949 0.406698920754611 no 2034 0.390141745333238 2999 3722427
SGTC_2087 5276107 200 µM -0.279895620378767 0.406347800499884 no 2035 0.389778793708734 2878 144405
SGTC_1506 4226-2149 212 µM -0.28182710061445 0.405631143387019 no 2036 0.389038044794169 3003 991114
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.282745998981699 0.40529030586144 no 2037 0.388685776138096 2918 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2290 7904846 200 µM -0.283522086888286 0.405002495479874 no 2038 0.388388326538941 2963 2962154
SGTC_2975 9084847 53.72 µM -0.284098292115886 0.404788844344085 no 2039 0.38816752788074 2991 27211724
SGTC_1377 2944-0135 198 µM -0.284357299564006 0.40469281621472 no 2040 0.38806828942848 2996 1894137
SGTC_2275 7947463 200 µM -0.284561803406118 0.404616999587483 no 2041 0.387989939143183 3031 1225414
SGTC_3157 9099274 49.47 µM -0.286050346477827 0.404065253404216 no 2042 0.387419780456289 3032 17217662
SGTC_2780 5215298 71.43 µM -0.286180047229768 0.404017187299606 no 2043 0.38737011247916 3055 2834131
SGTC_383 2324-0395 7.37 µM -0.286591757694706 0.403864620161102 no 2044 0.387212463113061 3043 3146421
SGTC_1861 st057647 17.4 µM -0.286639738428209 0.403846840939331 no 2045 0.387194091867185 3084 688668
SGTC_3081 9117243 49.47 µM -0.2868940180317 0.403752621156047 no 2046 0.387096735483346 3088 45595589
SGTC_1947 st076332 61.6 µM -0.287420309168663 0.403557629015692 no 2047 0.386895256235073 3007 24208416
SGTC_378 3970-0959 8.33 µM -0.288417183969155 0.403188350228291 no 2048 0.386513707719829 3039 6615653
SGTC_138 0850-0259 40.9225 µM -0.288910762716807 0.403005542585875 no 2049 0.386324833662692 2996 6813004
SGTC_1009 4106-0057 9.87 µM -0.289416716922323 0.402818173425943 no 2050 0.38613125193569 3062 2928005
SGTC_1458 k015-0034 6.33 µM -0.289923277133249 0.402630602201445 no 2051 0.385937466742018 2976 3598957
SGTC_249 wiskostatin 11.211 µM -0.292632044997416 0.401627969710161 no 2052 0.384901708543044 2945 2775510 A n-wasp and actin depolymerizer.
SGTC_1849 st056239 19.2 µM -0.293146371148314 0.401437668202608 no 2053 0.384705136889944 2909 5393181
SGTC_624 k048-0052 28 µM -0.293351217747006 0.401361881136203 no 2054 0.384626854283575 2972 6835531
SGTC_194 1486-1323 56.904 µM -0.297516847562619 0.399821532436685 no 2055 0.383035973756632 2972 5178754
SGTC_180 1486-1293 102.781 µM -0.298643796592968 0.399405080757913 no 2056 0.382605922343727 3060 4140536
SGTC_2044 5102272 200 µM -0.299475822026123 0.399097688272462 no 2057 0.382288508613748 3020 592666
SGTC_2919 7978188 46.38 µM -0.299782066069068 0.398984561898031 no 2058 0.382171697873395 3102 2980291
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.300496265174236 0.398720770137658 no 2059 0.381899322416604 3200 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_728 3030-5151 22.5 µM -0.300769310055858 0.39861993234037 no 2060 0.381795206213732 2930 3125388
SGTC_1972 st070201 17.4 µM -0.303691257186415 0.397541257437014 no 2061 0.380681559686144 3080 2829099
SGTC_2682 pyrogallin 40.03 µM -0.304645191381353 0.397189269320233 no 2062 0.380318198635772 2978 822798 An ATP competetive kinase inhibitor.
SGTC_2200 6600604 21.907 µM -0.305485499814239 0.396879276834178 no 2063 0.379998205989856 2932 2904777
SGTC_1515 3460-0031 42.1 µM -0.305760806522582 0.396777729462684 no 2064 0.379893386000974 2968 2876596
SGTC_2113 5491891 107.031 µM -0.308491387016886 0.395770930014641 no 2065 0.378854226527668 2966 789979
SGTC_1801 st050089 28.441 µM -0.31006667002559 0.395190419011584 no 2066 0.378255128739156 2943 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1159 4092-0538 61.2 µM -0.310169268628684 0.3951526182269 no 2067 0.378216119473201 2967 717301
SGTC_526 4469-0568 170 µM -0.312372278618638 0.394341193673595 no 2068 0.377378807759962 2949 2901964
SGTC_1719 st032227 49.2 µM -0.313525246081557 0.393916708927524 no 2069 0.376940821625553 2958 3125804
SGTC_1448 4255-0083 152 µM -0.313733108565407 0.393840194180606 no 2070 0.376861876218749 3117 5399660
SGTC_3168 9103419 49.47 µM -0.313835354924809 0.393802558520528 no 2071 0.376823045316328 3035 16649256
SGTC_3277 9138724 49.47 µM -0.313868834102435 0.393790235451844 no 2072 0.376810330937041 2993 15943418
SGTC_1420 4'-methoxyflavone 42 µM -0.314213975265792 0.393663201548406 no 2073 0.376679264550427 3043 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3215 9129942 49.47 µM -0.314471840609538 0.393568298083611 no 2074 0.376581350186652 3097 17682944
SGTC_1460 k062-0059 9.15 µM -0.314663319961819 0.393497831075411 no 2075 0.376508648464992 2858 1373085
SGTC_3078 9116413 49.47 µM -0.315007920786626 0.393371022070089 no 2076 0.376377819946569 2876 17177322
SGTC_3181 9108277 49.47 µM -0.316019866732587 0.392998703419367 no 2077 0.375993714407889 2972 17097298
SGTC_3286 9117135 37.221 µM -0.317112774079745 0.392596707096114 no 2078 0.375579016210818 2987 3438150
SGTC_2027 5150920 200 µM -0.31730385307244 0.392526435624633 no 2079 0.375506526993425 3018 786715
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.318618705236687 0.39204297891819 no 2080 0.375007833717034 3003 368090
SGTC_656 4090-1979 187 µM -0.319893414522519 0.39157444135991 no 2081 0.374524565115175 3099 22330961
SGTC_2195 6536160 144.242 µM -0.320142661859847 0.391482845308388 no 2082 0.374430093311314 2945 3834386
SGTC_3127 9126946 49.47 µM -0.320415581984276 0.391382556631278 no 2083 0.37432665749647 3047 27243249
SGTC_3348 9149464 3.537 µM -0.322342530635961 0.390674675664966 no 2084 0.373596608171407 2947 1951442
SGTC_3243 9134147 49.47 µM -0.324669951141506 0.3898201610178 no 2085 0.372715439576844 3043 24282180
SGTC_449 xestospongin c 11.1929 µM -0.32525542638344 0.389605286853701 no 2086 0.372493881450543 3086 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_188 3229-0966 278.469 µM -0.325859390248815 0.389383662571246 no 2087 0.372265370984906 3090 5722370
SGTC_2869 9037858 32.47 µM -0.327465546765483 0.388794459345746 no 2088 0.37165789871142 2937 27187042
SGTC_2096 5468907 200 µM -0.328431090469867 0.388440381805488 no 2089 0.371292869365843 3097 759785
SGTC_2864 9034755 47.6 µM -0.330759440534955 0.387586927054827 no 2090 0.370413099888952 3011 4930451
SGTC_1641 st009299 47.1 µM -0.33127428414326 0.387398284714946 no 2091 0.370218656986999 3049 4046054
SGTC_1644 st010134 20.9 µM -0.331968635182706 0.387143911692431 no 2092 0.369956471372343 3110 3818134
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.332150216179574 0.387077398131519 no 2093 0.36988791670075 3041 66535 A nucleotide analog.
SGTC_3064 1327-0027 10 µM -0.333536636835708 0.386569658310652 no 2094 0.369364619449993 2957 16000455 YPR107C YTH1
SGTC_858 0438-0351 2.77 µM -0.333585879859376 0.386551627923168 no 2095 0.369346037371091 3029 2799119
SGTC_3050 9093513 49.47 µM -0.333802970293833 0.386472142941275 no 2096 0.369264120948094 2998 25236664
SGTC_2767 sibutramine 71.45 µM -0.333826265304426 0.386463614043723 no 2097 0.369255331213059 3203 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_450 aminopyrene 156 nM -0.336106450312789 0.385629046201253 no 2098 0.368395297227369 3110 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1287 0971-0001 34.6 µM -0.336107402424192 0.385628697830344 no 2099 0.368394938249916 3024 4665869
SGTC_1299 1079-1439 3.74 µM -0.336132491292111 0.385619518022134 no 2100 0.368385478959267 3017 323161
SGTC_2013 4024628 200 µM -0.337548183714761 0.385101631881802 no 2101 0.3678518478886 3149 5230760
SGTC_3346 9158254 43.5805 µM -0.339367543174522 0.38443637789915 no 2102 0.367166433052608 3091 17639500
SGTC_575 k072-0246 11.9 µM -0.34258871278003 0.383259383527939 no 2103 0.365953947330743 3008 6796779
SGTC_446 go6976 132 µM -0.344339110771392 0.382620250321882 no 2104 0.365295637235589 3138 3501 A protein kinase C inhibitor.
SGTC_2400 5203494 178.7 µM -0.344613246127132 0.382520182551364 no 2105 0.365192573093954 3005 6777674
SGTC_1721 st082152 9.2685 µM -0.346474422583048 0.381841004068241 no 2106 0.364493101531686 2968 5296051
SGTC_1825 st052143 62.6 µM -0.347716248582819 0.381388040343556 no 2107 0.364026646332252 3184 674173
SGTC_410 α-linolenic acid 100 µM -0.348220701483892 0.381204084378119 no 2108 0.363837221003097 3135 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2611 pyromycin 23.93 µM -0.348920190613632 0.380949050080886 no 2109 0.363574613371035 3034 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2880 9042983 58.44 µM -0.348937611145873 0.380942699200366 no 2110 0.363568074037186 3143 6464714
SGTC_667 1498-1044 59 µM -0.349324840783769 0.380801537906661 no 2111 0.363422725719681 3066 6739982
SGTC_1525 8-methoxypsoralen 92.5 µM -0.349961556300354 0.380569463141527 no 2112 0.36318377454862 3252 4114 Related to psoralen; DNA damaging agent.
SGTC_2312 7706453 155.7 µM -0.351234708023266 0.380105544362869 no 2113 0.362706136770343 3046 976098
SGTC_2636 apigenin dimethyl ether 100 µM -0.351754047456117 0.379916353778221 no 2114 0.362511361781147 3169 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.352934622083416 0.379486388258767 no 2115 0.362068727126686 3279 6728940
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.353248475931118 0.379372107671921 no 2116 0.361951084426476 2979 6312947
SGTC_3290 9121031 71.43 µM -0.354718535196369 0.378836969554015 no 2117 0.36140023184706 3063 17014854
SGTC_888 0916-0002 6.97 µM -0.355072729883755 0.378708068555152 no 2118 0.361267552839572 3193 2802138 YIL048W NEO1
SGTC_3235 9132602 49.47 µM -0.355155643921095 0.378677895849168 no 2119 0.361236496194419 3147 4912240
SGTC_551 k048-0028 34.9 µM -0.356456149403475 0.378204734263265 no 2120 0.360749492948754 3169 6836383
SGTC_77 0828-0286 12.516 µM -0.356720166435776 0.378108699490136 no 2121 0.360650653428788 3116 745345
SGTC_1669 st015249 58.4 µM -0.359715788744412 0.377019586821514 no 2122 0.359529841819937 3134 722793
SGTC_2128 5255449 168.493 µM -0.361688731211578 0.376302821340299 no 2123 0.35879232447164 3036 736008
SGTC_3190 9110366 49.47 µM -0.362918558973399 0.375856243291698 no 2124 0.358332861270534 3153 17123768
SGTC_668 1682-0499 62.6 µM -0.363564877215669 0.375621617233362 no 2125 0.358091479160577 3087 682214
SGTC_1400 3771-8998 51.5 µM -0.364002597845874 0.375462742268408 no 2126 0.357928034734267 3031 670767
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.365502597033275 0.374918463292834 no 2127 0.35736813428307 3043 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1754 st042065 16.137 µM -0.365729704097305 0.374836078527348 no 2128 0.357283389394367 3123 1126236 YIL048W NEO1
SGTC_933 2914-0560 114 µM -0.365924516875826 0.37476541330339 no 2129 0.357210700710643 3223 463887
SGTC_193 1273-0060 1.558 µM -0.366318238398797 0.374622609948036 no 2130 0.357063810874104 3105 2847393 YHR072W ERG7
SGTC_2092 5303694 80.6725 µM -0.366346575567423 0.374612332679774 no 2131 0.357053239645031 3052 1963699
SGTC_346 4513-0042 7.16 µM -0.366457962900817 0.374571935805253 no 2132 0.357011687473953 3008 2827372
SGTC_1060 3448-7350 82 µM -0.366912713751382 0.374407025477392 no 2133 0.35684206383768 3175 570178
SGTC_1664 st014217 9.02 µM -0.369541339980965 0.373454234532854 no 2134 0.35586213271246 3138 3982782
SGTC_1855 st056195 39.6 µM -0.370344923173358 0.373163115959128 no 2135 0.355562752852835 3220 4028379
SGTC_512 prima-1 270 µM -0.370721531423025 0.373026704889087 no 2136 0.355422475781599 3198 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3077 9117319 49.47 µM -0.370937455101184 0.372948502468464 no 2137 0.355342058490863 3072 17154678
SGTC_116 0155-0182 31.788 µM -0.372862678469367 0.372251464132549 no 2138 0.3546253252092 3073 771486
SGTC_1307 1187-1599 12.2 µM -0.373039143235336 0.372187594931588 no 2139 0.354559655583208 3029 1538471
SGTC_739 1486-1183 203 µM -0.374254672465574 0.371747745033262 no 2140 0.354107425877445 3195 4346692
SGTC_2190 6049624 200 µM -0.37441987225153 0.371687978949914 no 2141 0.354045980240333 3144 2265554
SGTC_596 1155-0152 116 µM -0.376747185778819 0.370846331269469 no 2142 0.353180746519364 3099 280313
SGTC_2265 7929201 200 µM -0.377454889549568 0.370590520143615 no 2143 0.352917791114162 3002 1265108
SGTC_3021 9087658 49.47 µM -0.378951625106412 0.370049689095297 no 2144 0.352361893430593 3196 25237042
SGTC_265 mycophenolic acid 32.932 µM -0.378968975118061 0.370043421338902 no 2145 0.352355451365276 3313 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1254 0550-0035 264 µM -0.379131311178403 0.369984778504329 no 2146 0.35229517798247 3199 15121435
SGTC_2289 7946404 165.07 µM -0.380337954550253 0.369548981343154 no 2147 0.35184728248974 3041 1246120 YPR165W RHO1
SGTC_679 0422-0091 41.4 µM -0.380760484126098 0.369396418092162 no 2148 0.351690491749338 3066 627384 YHR062C RPP1
SGTC_2082 5219693 150 µM -0.381185928451925 0.369242823186396 no 2149 0.351532644898616 3051 2834649
SGTC_1335 1486-0900 202 µM -0.381528344116986 0.369119218639956 no 2150 0.35140562163803 3032 X1335
SGTC_3326 9140064 16.379 µM -0.381787296174488 0.369025751611145 no 2151 0.351309571237717 3037 1868434
SGTC_2624 nerol 100 µM -0.38197437300531 0.368958232286906 no 2152 0.351240186677179 3048 637566 A natural product oil.
SGTC_2641 levomentholum 100 µM -0.382695172059592 0.368698121030832 no 2153 0.350972897294051 3129 16666
SGTC_2083 5306046 65.942 µM -0.383270131635083 0.368490681272644 no 2154 0.350759741498241 3099 539837
SGTC_3210 9128157 49.47 µM -0.383357921289038 0.36845901100011 no 2155 0.350727199213837 3143 17590849
SGTC_2411 st077133 39.94 µM -0.385013554740693 0.367861905871121 no 2156 0.350113686496177 3341 1403142 YNL221C POP1
SGTC_1144 3486-0183 12.5 µM -0.386126369095403 0.367460748020188 no 2157 0.349701540821875 3096 6744069
SGTC_2268 7933382 153.85 µM -0.386276218274631 0.367406740006638 no 2158 0.349646055691547 3111 935025 YOR257W CDC31
SGTC_670 4204-0025 119 µM -0.386330594005432 0.367387142781966 no 2159 0.34962592261151 3167 719039
SGTC_2825 7998094 58.44 µM -0.386827459862741 0.36720808639978 no 2160 0.349441973367669 3116 2987815
SGTC_1310 1188-0297 994 nM -0.38746692482958 0.366977683837048 no 2161 0.349205283238107 3110 1588352
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.389988595482894 0.366069580390974 no 2162 0.348272490039093 3020 4000243
SGTC_1336 1486-0901 104 µM -0.390126776298573 0.366019840368739 no 2163 0.34822140191561 3131 5006114
SGTC_1606 st000094 49.2 µM -0.391678956917857 0.365461267192227 no 2164 0.347647720091885 3220 1242210
SGTC_1303 1160-0052 261 µM -0.391766761583646 0.365429678009006 no 2165 0.347615278129907 3146 3562476
SGTC_1472 k841-0093 193 µM -0.391882013183583 0.365388215721952 no 2166 0.347572696801574 3226 X1472
SGTC_2794 7785382 27.27 µM -0.392757766930132 0.365073210754587 no 2167 0.347249200095459 3206 2205081
SGTC_1056 3448-1962 115 µM -0.393186023573989 0.364919201755605 no 2168 0.347091045871785 3169 715507
SGTC_3313 9133968 57.047 µM -0.393503554244723 0.364805025928236 no 2169 0.346973799693036 3157 1494643
SGTC_2513 baicalein 25.65 µM -0.394073666084168 0.364600058528741 no 2170 0.346763326294636 3134 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_802 4112-3352 742 µM -0.394172954427419 0.364564366201167 no 2171 0.346726675942017 3238 704594
SGTC_1793 st048256 72.231 µM -0.39456177866777 0.364424602364759 no 2172 0.346583162878101 3086 672022
SGTC_13 0199-0087 65 µM -0.39532234156741 0.364151268267466 no 2173 0.346302506617799 3129 4589825
SGTC_597 k018-0003 82.8 µM -0.395765292455636 0.363992110654322 no 2174 0.346139091629411 3221 6786234
SGTC_2596 sinensetin 100 µM -0.396157505205287 0.363851203448702 no 2175 0.345994419042495 3126 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_647 0140-0236 81 µM -0.397194311947037 0.363478806702687 no 2176 0.345612088178872 3142 990837
SGTC_2076 5212012 200 µM -0.397402012398463 0.363404221050554 no 2177 0.345535515874106 3124 604802
SGTC_884 0851-0618 334 µM -0.398192614125118 0.363120361761441 no 2178 0.34524410493628 3198 9642473
SGTC_601 0986-0029 62.9 µM -0.399562261472466 0.362628778719319 no 2179 0.34473947852752 3128 24747981
SGTC_318 1488-0629 67.2 µM -0.399737282047098 0.362565978006393 no 2180 0.34467501464977 3189 3662576
SGTC_103 0844-0104 51.839 µM -0.399919890251364 0.362500458648912 no 2181 0.344607760890699 3213 5375804
SGTC_926 2268-1401 59.4 µM -0.400529551573261 0.362281742896584 no 2182 0.344383261019569 3157 2931578
SGTC_3327 9140648 26.9345 µM -0.401205805772837 0.362039189560504 no 2183 0.344134303309457 3232 8029710
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.404899523996765 0.360715336763733 no 2184 0.34277568414351 3110 3256 An antibiotic and ribosome inhibitor.
SGTC_2433 5607874 27.82 µM -0.405743911689855 0.360412936266412 no 2185 0.342465387009376 3100 2252428
SGTC_178 4092-0806 87.505 µM -0.406581508788575 0.360113053922615 no 2186 0.342157690307222 3204 2169044
SGTC_1200 1643-0193 18.4 µM -0.407579238645618 0.359755952058616 no 2187 0.341791304545469 3235 5403974
SGTC_2182 6325192 200 µM -0.409070151985911 0.359222560916147 no 2188 0.341244089942631 3230 736248
SGTC_93 0109-0045 59.227 µM -0.410484282474305 0.358716893115097 no 2189 0.340725365481413 3210 88733
SGTC_3052 9092717 49.47 µM -0.413634963572074 0.357591157127104 no 2190 0.339570731715474 3267 25237534
SGTC_1166 k206-0078 225 µM -0.413669059249642 0.357578981520074 no 2191 0.33955824484048 3116 5404595
SGTC_1903 st060211 78.3 µM -0.414050504877579 0.357442776716543 no 2192 0.339418559849785 3278 688960
SGTC_126 0417-1624 672.48 µM -0.414443023068494 0.357302637130039 no 2193 0.339274843127868 3266 41912 YDL195W SEC31
SGTC_156 3474-0145 5.642 µM -0.414819673927556 0.357168180701503 no 2194 0.339136958054102 3254 2265471
SGTC_2378 9074213 121.43 µM -0.414903049858969 0.357138419645801 no 2195 0.339106438543612 3132 657714
SGTC_167 3672-0051 66.205 µM -0.414999271224997 0.357104074489951 no 2196 0.339071218312438 3086 3237971
SGTC_673 1082-0474 110 µM -0.415328946494445 0.356986409318066 no 2197 0.338950556827177 3159 3098046
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.415353548422824 0.35697762913152 no 2198 0.338941553158544 3260 756377
SGTC_2841 9004761 38.96 µM -0.416126201395606 0.356701915447063 no 2199 0.338658829022874 3151 2991039
SGTC_1859 st055998 20 µM -0.416253276560884 0.356656577076516 no 2200 0.338612339206738 3312 676301
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.420849071459805 0.355018237173498 no 2201 0.33693264806674 3304 165506
SGTC_2350 9023895 38.85 µM -0.421112007157609 0.354924584763536 no 2202 0.33683664706133 3277 2997209
SGTC_864 0469-0573 172 µM -0.423363315387914 0.354123073370182 no 2203 0.336015102866391 3163 689425
SGTC_1388 3346-4487 254 µM -0.425063931294007 0.353518047596237 no 2204 0.335395035249872 3224 3345614
SGTC_1562 morin hydrate 59.1 µM -0.425969571058073 0.353196000230685 no 2205 0.335065009460305 3307 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2125 5246583 200 µM -0.426657088468358 0.352951587791217 no 2206 0.334814555008121 3318 835267
SGTC_3152 9099253 49.47 µM -0.427207029426625 0.352756127443872 no 2207 0.334614270902056 3192 25236131
SGTC_1436 4092-1007 8.32 µM -0.429085339245371 0.352088830733435 no 2208 0.33393056053496 3159 2881121
SGTC_2220 6782180 200 µM -0.429997611193905 0.351764897041038 no 2209 0.333598689437169 3205 833803
SGTC_1987 st072290 61.9 µM -0.43084542246239 0.351463948782836 no 2210 0.333290384869147 3196 54697379
SGTC_1366 1683-0113 21.9 µM -0.431250032000661 0.351320357005918 no 2211 0.333143289243676 3152 708623
SGTC_1183 1254-0324 198 µM -0.433248473264677 0.350611442267334 no 2212 0.332417133575392 3279 5799357
SGTC_1640 st009078 66.4 µM -0.433970050850238 0.350355601905042 no 2213 0.332155094703374 3257 690618
SGTC_3265 9137266 49.47 µM -0.43543638336014 0.34983591272441 no 2214 0.331622853050052 3232 17224265
SGTC_2865 9030313 51.95 µM -0.435627471145218 0.349768209174572 no 2215 0.331553518012837 3110 42562754
SGTC_1025 k007-0731 70 µM -0.437950315629849 0.348945593968384 no 2216 0.330711150158235 3135 6256118
SGTC_2967 9089538 49.85 µM -0.438007449589609 0.348925369396568 no 2217 0.330690441592929 3350 728216
SGTC_357 1325-0123 420 µM -0.438738234470082 0.348666720291093 no 2218 0.33042560971287 3265 1098503
SGTC_525 k781-2675 26.7 µM -0.438858494304634 0.348624163066495 no 2219 0.330382036431327 3280 3651118 YDL195W SEC31
SGTC_3234 9132280 49.47 µM -0.440214438516025 0.34814445713696 no 2220 0.329890901657808 3246 17612295
SGTC_904 1141-0088 396 µM -0.441569937549492 0.347665151435255 no 2221 0.329400221061086 3209 1378119
SGTC_1046 2001-0062 216 µM -0.441789599812247 0.34758750155521 no 2222 0.32932073257726 3177 739778
SGTC_1784 st039334 36.3 µM -0.442351385386776 0.347388941316251 no 2223 0.329117476116922 3368 3496984
SGTC_3291 9121177 71.43 µM -0.44254659571025 0.347319955025762 no 2224 0.329046859995292 3200 17015612
SGTC_3025 9087895 49.47 µM -0.44259105912086 0.347304242599977 no 2225 0.329030776485658 3296 17173641
SGTC_3262 9137218 49.47 µM -0.442824642695764 0.347221703432345 no 2226 0.328946288758769 3186 17650664
SGTC_2150 5556613 200 µM -0.443228373096084 0.347079058214564 no 2227 0.328800279133323 3190 743190
SGTC_919 tnp00227 403.569 nM -0.443318435587655 0.347047240469937 no 2228 0.328767711479193 3174 1269246 A methoxyflavone. YNL221C POP1
SGTC_1602 st001878 87.6 µM -0.444714773743248 0.346554072956407 no 2229 0.328262945701694 3324 595405 YLR310C CDC25
SGTC_2325 6158266 200 µM -0.44588506616196 0.346140941894966 no 2230 0.327840135095715 3225 3623240
SGTC_1753 st043925 64 µM -0.447657067013219 0.345515747103363 no 2231 0.327200355471004 3268 670181
SGTC_1883 5-benzylidenerhodanine 20 µM -0.447892979662322 0.345432544474539 no 2232 0.327115217610173 3281 1273210
SGTC_3136 9095672 49.47 µM -0.447937713581124 0.345416768377019 no 2233 0.327099074724911 3207 17217380
SGTC_921 1561-0023 372 µM -0.448112599764198 0.34535509467935 no 2234 0.327035967606474 3160 24050882
SGTC_2361 9034121 116 µM -0.449515990936261 0.344860336892463 no 2235 0.326529737603262 3202 6496917
SGTC_784 4579-0127 173 µM -0.449628566638014 0.344820660429763 no 2236 0.326489143218558 3367 1948547
SGTC_1002 4049-0206 172 µM -0.450744347229003 0.344427504259028 no 2237 0.326086908006156 3189 4662749
SGTC_2351 9026858 72.31 µM -0.451666390535646 0.344102740082727 no 2238 0.325754667046118 3131 1409300
SGTC_2747 doxorubicin 7.63 µM -0.451799619156296 0.344055823496526 no 2239 0.325706672051958 3194 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2819 7996655 46.38 µM -0.452088373498284 0.343954146619264 no 2240 0.325602659552914 3192 6456960
SGTC_2176 5809774 33.9695 µM -0.453230175415588 0.3435522031467 no 2241 0.325191502963962 3281 2870539
SGTC_1122 capsaicin 818.572 nM -0.453831228309827 0.343340688171599 no 2242 0.324975152557128 3311 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_39 0986-0283 58.349 µM -0.455144685690856 0.342878643582223 no 2243 0.324502575924161 3387 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1001 4048-4355 44.4 µM -0.456971667795662 0.34223634331414 no 2244 0.323845704966423 3184 21824233
SGTC_1878 temozolomide 1 mM -0.459894580492351 0.341209703002743 no 2245 0.322795945205416 3308 5394 DNA alkylating agent.
SGTC_837 0091-0265 12.5 µM -0.461257355046456 0.340731444609665 no 2246 0.322306988323951 3201 759367
SGTC_1091 telmisartan 47.6 µM -0.463217351632099 0.340044043201015 no 2247 0.321604290005142 3330 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1364 1653-0028 37.6 µM -0.46706667864062 0.338695572391989 no 2248 0.320226086606554 3261 5718652
SGTC_554 4483-2211 187 µM -0.467138267416471 0.338670513392521 no 2249 0.32020047853988 3275 747107
SGTC_3163 9099914 49.47 µM -0.467986142168928 0.338373776895886 no 2250 0.31989724988332 3293 16268368
SGTC_1372 2752-0194 270 µM -0.468196700180994 0.33830010202209 no 2251 0.319821965864186 3293 823334
SGTC_465 cgp-37157 41 µM -0.469323267287862 0.337906018071913 no 2252 0.319419293276765 3257 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_109 0132-0036 33.701 µM -0.469574025547899 0.337818324584223 no 2253 0.319329692873871 3250 67274 A color developer.
SGTC_1986 st071812 45 µM -0.472885442461447 0.336661105446117 no 2254 0.31814745570587 3311 11838594
SGTC_345 1362-0200 395 µM -0.472959388918542 0.336635281459267 no 2255 0.318121076529118 3243 1419823
SGTC_1510 1123-0200 71.5 µM -0.473352387935974 0.336498049118797 no 2256 0.317980896106468 3423 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1882 5615643 20 µM -0.474906148926738 0.33595570069495 no 2257 0.317426934255267 3293 2253075
SGTC_2479 5617353 43.85 µM -0.476467917778437 0.335410901083835 no 2258 0.316870529142793 3385 2731746
SGTC_3206 9114350 49.47 µM -0.476845002413022 0.335279412571398 no 2259 0.316736248705469 3310 17087243
SGTC_3164 9100705 49.47 µM -0.477120882739695 0.335183226540117 no 2260 0.316638022575107 3372 17174235
SGTC_1767 st044992 70.3 µM -0.477301091675551 0.335120402296716 no 2261 0.316573866856263 3285 9600693
SGTC_19 0279-0214 38.434 µM -0.478237365665034 0.334794073740667 no 2262 0.316240635211479 3298 3566274 YBR002C RER2
SGTC_2612 dictamnine 15.46 µM -0.479164613161378 0.334471014188821 no 2263 0.315910763232459 3283 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_943 3253-1379 105 µM -0.482041877930008 0.333469335816229 no 2264 0.314888098635027 3381 668464
SGTC_1270 0831-1170 17.3 µM -0.482219817046629 0.333407427746935 no 2265 0.31482490030741 3339 6764716
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.482577617079577 0.333282956717458 no 2266 0.314697837505844 3284 91467 include heat shock
SGTC_1390 3413-2614 145 µM -0.483276011772811 0.333040052940218 no 2267 0.314449885127926 3296 3421432
SGTC_1478 0453-0656 35.7 µM -0.48621870559341 0.33201734538987 no 2268 0.313406055152679 3347 5258496
SGTC_722 3534-0461 190 µM -0.487052638106764 0.331727746430269 no 2269 0.313110514385903 3303 658262
SGTC_572 0960-0087 17.7 µM -0.487472398543563 0.331582014644199 no 2270 0.312961799160203 3283 6796365
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.48862782551569 0.331181006975717 no 2271 0.312552604822716 3208 6708514
SGTC_2387 9077560 195.08 µM -0.489292138005167 0.330950535295346 no 2272 0.312317443166515 3242 5303272
SGTC_370 0180-0345 38.7 µM -0.490280809114033 0.330607651636742 no 2273 0.311967602515451 3208 3989527
SGTC_114 0364-0001 490.298 µM -0.490755017862585 0.330443240449854 no 2274 0.311799864191344 3329 4003655
SGTC_1340 1486-1359 257 µM -0.490901063311586 0.330392612153494 no 2275 0.311748212483992 3257 4309068
SGTC_797 k781-0471 270 µM -0.49110849717909 0.330320708207883 no 2276 0.311674855978161 3254 23738129
SGTC_3283 9109332 35.8195 µM -0.492184174907837 0.329947940630591 no 2277 0.311294575318704 3240 17027281
SGTC_992 3909-8734 162 µM -0.494516542471852 0.329140257337872 no 2278 0.310470713220264 3290 4288319
SGTC_807 1315-0151 48 µM -0.496170135250673 0.32856811171118 no 2279 0.309887189845469 3450 4011080
SGTC_1454 4239-0054 42.6 µM -0.497471689153084 0.328118054498206 no 2280 0.309428231230094 3443 1340767
SGTC_1151 3909-8316 15.3 µM -0.497931879748832 0.327958987354477 no 2281 0.309266028224888 3368 800431
SGTC_905 2-aminofluorene 215 µM -0.502059049329647 0.326533808527301 no 2282 0.307812992396183 3371 1539 An established DNA mutagen. YPR165W RHO1
SGTC_598 3937-0236 20.2 µM -0.502360227833839 0.326429905419976 no 2283 0.30770707523084 3359 1379313
SGTC_3266 9136860 49.47 µM -0.503288764021657 0.326109655937731 no 2284 0.307380632491009 3343 4871271 YPR165W RHO1
SGTC_2239 6685329 187.64 µM -0.503453968861475 0.326052690687135 no 2285 0.307322567886758 3371 805680
SGTC_2359 9039622 200 µM -0.504068735928949 0.325840744912384 no 2286 0.307106537916566 3310 6463596
SGTC_1885 st057546 99.9 µM -0.505078438704833 0.325492764078164 no 2287 0.30675187228318 3445 702008
SGTC_782 0083-0095 30.5 µM -0.506316386269424 0.325066329177098 no 2288 0.306317280752424 3349 3591729 An indicator and reagent.
SGTC_1862 st057513 3.81 µM -0.507246917002513 0.324745940682068 no 2289 0.30599078964154 3248 5393163
SGTC_2414 st077232 92.9 µM -0.507409503357833 0.324689974313367 no 2290 0.305933759507955 3213 729801
SGTC_1058 3448-5425 97.3 µM -0.507641882046005 0.324609990515314 no 2291 0.305852256606662 3354 7279705
SGTC_1774 st048371 48.465 µM -0.50942927462144 0.323995047861634 no 2292 0.305225680449921 3254 4242727
SGTC_518 1021-0119 62.6 µM -0.509999803895811 0.323798861357769 no 2293 0.305025799591227 3270 1097762
SGTC_2540 epiandrosterone 100 µM -0.510069675779747 0.323774838047418 no 2294 0.305001324471399 3419 441302 A steroid.
SGTC_1250 0485-0349 40.2 µM -0.512096333461767 0.323078353615461 no 2295 0.304291795254991 3279 6842794 YDL195W SEC31
SGTC_2452 5863136 48.41 µM -0.512643530432978 0.322890409194595 no 2296 0.304100348674772 3304 2184096
SGTC_1935 st074532 41.6 µM -0.513248830751889 0.322682560836175 no 2297 0.303888636159741 3383 2829742
SGTC_846 0335-0850 148 µM -0.51463098928023 0.322208162198064 no 2298 0.303405452900804 3366 6819598
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.514665375403412 0.322196363527277 no 2299 0.30339343637109 3298 6708784 An antioxidant flavonoid
SGTC_2996 9066192 71.4286 µM -0.515214364533346 0.322008016984063 no 2300 0.303201616153953 3329 6472854
SGTC_766 1391-0721 126 µM -0.515368929963653 0.321954997102836 no 2301 0.303147619815976 3410 1020919 YIL115C NUP159
SGTC_573 3702-0553 84.7 µM -0.515611338544468 0.321871852081797 no 2302 0.303062944758396 3349 1222756
SGTC_1492 4158-0558 28.5 µM -0.516317863422252 0.321629568204451 no 2303 0.30281621093166 3391 3967268
SGTC_1353 1498-1206 8.11 µM -0.516838563064449 0.321451056677442 no 2304 0.302634428906323 3434 6756808
SGTC_1019 4262-0212 3.4 µM -0.516885798664371 0.321434864929597 no 2305 0.302617940853395 3400 4677213
SGTC_417 st075190 100 µM -0.517475672605747 0.321232692416214 no 2306 0.302412073436371 3434 222757
SGTC_849 0386-0493 241 µM -0.518010996920809 0.321049262002263 no 2307 0.302225298351677 3304 726119
SGTC_1896 st058441 89 µM -0.522634305241018 0.319466892859193 no 2308 0.300614381448236 3322 688759
SGTC_1926 methyl fluorone black 53.6 µM -0.523439803552158 0.319191538663451 no 2309 0.300334115582548 3298 72721 Reacts with homocysteine.
SGTC_1772 st048439 82.2 µM -0.524107081400771 0.31896350971334 no 2310 0.300102031746742 3379 2927068 YDL195W SEC31
SGTC_787 4152-0075 138 µM -0.524554752599615 0.31881056536208 no 2311 0.299946374097851 3344 9566539
SGTC_2752 diclazuril 33.15 µM -0.524851562610302 0.318709178896203 no 2312 0.299843191831377 3391 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3118 9124250 49.47 µM -0.525229682937778 0.318580037530597 no 2313 0.299711766337269 3313 1504786
SGTC_614 0462-0418 107 µM -0.525524110032127 0.31847949559983 no 2314 0.299609448661924 3309 5188303
SGTC_2989 9073649 71.4286 µM -0.527290454312349 0.317876599390287 no 2315 0.2989959510505 3437 21367202
SGTC_1052 3253-3998 198 µM -0.527343580461432 0.317858473610948 no 2316 0.298977507788415 3338 5450317
SGTC_1190 1486-1332 13 µM -0.527716740686494 0.31773116970242 no 2317 0.298847976130663 3376 4150046
SGTC_3320 9137005 35.139 µM -0.528089186639304 0.317604130950556 no 2318 0.298718717843679 3344 4908713
SGTC_1554 st069299 38.7 µM -0.528132036471008 0.317589516544969 no 2319 0.298703848334162 3385 24207999
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.52841345191262 0.31749354378333 no 2320 0.298606201480552 3362 4620898
SGTC_1223 0764-0573 147 µM -0.530147370171718 0.316902486271086 no 2321 0.29800487890855 3392 1609797
SGTC_208 k072-0098 12.366 µM -0.531366796565411 0.316487088162936 no 2322 0.297582312869691 3398 5948901
SGTC_3322 9139058 2.11 µM -0.532216482808642 0.316197778941727 no 2323 0.297288034125714 3448 4908926 YPR165W RHO1
SGTC_2597 laccaic acid a 100 µM -0.532526506972091 0.316092246978127 no 2324 0.297180694057667 3379 5491415 A textile dye.
SGTC_3140 9094243 49.47 µM -0.532665390606521 0.316044975964851 no 2325 0.297132613943534 3457 19291112
SGTC_3208 9114115 49.47 µM -0.53355696262599 0.315741588438807 no 2326 0.296824045431941 3360 650895
SGTC_705 1124-0212 310 µM -0.533885344365562 0.31562987671166 no 2327 0.296710431163537 3449 9554485
SGTC_1260 0700-1617 7.75 µM -0.534761565642354 0.315331878672842 no 2328 0.29640737161235 3400 2853078
SGTC_1944 st076371 56.9 µM -0.535061610822884 0.315229862549834 no 2329 0.296303627301172 3300 24208455
SGTC_2940 9060638 45.86 µM -0.535390294983551 0.315118125270005 no 2330 0.296189999824977 3384 4027022
SGTC_2053 5265679 138 µM -0.53567573126582 0.315021103972824 no 2331 0.296091339539924 3344 764595
SGTC_754 3474-0146 171 µM -0.536049477314359 0.314894085015591 no 2332 0.295962178028279 3276 24762078
SGTC_1539 benzyladenosine 56 µM -0.536375119790742 0.314783432078749 no 2333 0.295849661544833 3353 92208 A nucleotide analog.
SGTC_1067 clotrimazole 1.36 µM -0.5367712031237 0.314648865832384 no 2334 0.295712832717484 3370 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2036 5160441 105 µM -0.536978500769115 0.314578447873019 no 2335 0.295641232377437 3367 134534 YIL048W NEO1
SGTC_1611 st001856 99.4 µM -0.537710837920032 0.314329730667216 no 2336 0.295388347893135 3359 647478
SGTC_631 k072-0230 41.5 µM -0.538471467556467 0.314071493945137 no 2337 0.29512579909442 3425 5773147
SGTC_43 0570-0105 72.5 µM -0.538641597066942 0.314013746764359 no 2338 0.295067089693262 3417 1114046 YDL195W SEC31
SGTC_2143 5623677 140.463 µM -0.539208669378 0.313821297900037 no 2339 0.294871439539217 3404 5375313
SGTC_818 4072-2707 53.5 µM -0.539290551112746 0.313793513657001 no 2340 0.294843193807895 3359 882871
SGTC_1404 3909-7820 48.3 µM -0.539894991558962 0.313588446619913 no 2341 0.294634726043026 3436 23741373
SGTC_2671 danthron 100 µM -0.539927090399135 0.313577558134582 no 2342 0.294623657253445 3391 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2549 cedrol 20.94 µM -0.54031182150785 0.313447063288071 no 2343 0.294491003600233 3418 6708665 A sedative which affects the nervous system.
SGTC_1647 st011722 22.4 µM -0.540944509027006 0.313232516232453 no 2344 0.294272915589977 3449 2854783
SGTC_2907 7721985 69.9 µM -0.541018143515167 0.313207550565783 no 2345 0.294247538556427 3383 3267881
SGTC_2761 levamisole 97.89 µM -0.541535880647244 0.31303203671827 no 2346 0.294069136686201 3465 26879 An alkaline phosphatase inhibitor.
SGTC_1444 4112-3581 28 µM -0.542599598228626 0.312671567437648 no 2347 0.293702757831536 3437 2877249
SGTC_2331 7980721 200 µM -0.542690329574777 0.312640828968598 no 2348 0.293671516792378 3351 2981221
SGTC_1082 camptothecin 424.86 nM -0.544193147241099 0.312131885736245 no 2349 0.293154283503643 3224 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_409 arachidonic acid 100 µM -0.546711345561939 0.311279877994574 no 2350 0.292288529179984 3377 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_662 k832-1615 104 µM -0.548341307253225 0.310728934529438 no 2351 0.291728784561398 3405 5878478
SGTC_2005 4024620 188 µM -0.548493555086437 0.310677494869085 no 2352 0.291676526701854 3444 236743
SGTC_3040 9091894 49.47 µM -0.548546840084291 0.310659492451366 no 2353 0.29165823808039 3362 25236966
SGTC_3182 9108849 49.47 µM -0.550946090113194 0.309849372486011 no 2354 0.29083531544669 3470 17133045
SGTC_2175 5807670 165.306 µM -0.552062017654348 0.309472887489668 no 2355 0.290452931850404 3417 241186
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.552913842491798 0.309185638381924 no 2356 0.290161204129324 3353 2724 A muscle relaxant with antifungal properties.
SGTC_2653 dihydrofissinolide 100 µM -0.553763442288863 0.308899255734331 no 2357 0.289870375255721 3449 6857746
SGTC_2884 9058502 51.95 µM -0.556101277142851 0.308111819471547 no 2358 0.289070811038151 3461 6471554
SGTC_2711 st079103 59.1 µM -0.556103361362147 0.308111117851999 no 2359 0.289070098676159 3379 54693780
SGTC_2194 5927483 104.545 µM -0.556498975142427 0.30797795341515 no 2360 0.288934897427338 3446 760979
SGTC_2148 5546263 113.568 µM -0.556772136939199 0.307886021328031 no 2361 0.288841561586961 3355 792097
SGTC_868 0527-0199 213 µM -0.559509585996248 0.306965404622874 no 2362 0.287906995441675 3344 2849450
SGTC_2270 7924575 90.91 µM -0.559911328573171 0.30683039892019 no 2363 0.287769960616515 3473 1262135
SGTC_3199 9111318 49.47 µM -0.560453825713483 0.306648134180464 no 2364 0.287584963171806 3405 8548020
SGTC_3304 9125678 46.087 µM -0.561343186937817 0.30634943568888 no 2365 0.287281802978501 3401 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2922 7999257 32.47 µM -0.562256219087754 0.306042920960913 no 2366 0.286970731387026 3470 2988377
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.562284647702577 0.306033379346933 no 2367 0.286961048272009 3352 803109
SGTC_3315 9136395 68.55 µM -0.564983095914784 0.305128287857887 no 2368 0.286042630993034 3538 16876844
SGTC_1264 0783-0040 158 µM -0.565429036680073 0.304978828526956 no 2369 0.285890989574926 3384 2855798
SGTC_1994 st072947 40.9 µM -0.565604221250644 0.30492012341867 no 2370 0.285831428810385 3484 5286565 YDL195W SEC31
SGTC_2645 abamectin 100 µM -0.566372488804729 0.304662732941354 no 2371 0.285570296271236 3452 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2466 5983409 37.09 µM -0.567422012863624 0.304311270149999 no 2372 0.285213748849147 3399 2879657
SGTC_1860 st056228 74.6 µM -0.567826606030393 0.304175828926254 no 2373 0.285076355933339 3453 688679
SGTC_1936 st074407 74.3 µM -0.567937511874517 0.304138706881788 no 2374 0.285038699717339 3394 809813
SGTC_3080 9117754 49.47 µM -0.567979716151296 0.304124580933414 no 2375 0.285024370587248 3552 9550191
SGTC_2614 arthonioic acid 13.39 µM -0.56935480096795 0.303664494322769 no 2376 0.28455769194851 3443 6710684
SGTC_1716 st033144 30.6155 µM -0.56981808272891 0.303509555895212 no 2377 0.284400544814252 3528 674617
SGTC_1759 st043059 70 µM -0.570015232828249 0.303443632376254 no 2378 0.284333683246333 3370 669426
SGTC_2108 5365811 200 µM -0.571622421181816 0.302906455726278 no 2379 0.283788901148258 3463 780283
SGTC_1344 1488-0097 29.1 µM -0.57258387131808 0.302585310239303 no 2380 0.283463241393513 3481 747966
SGTC_566 0958-0068 16.5 µM -0.574703227082563 0.301877938332135 no 2381 0.28274601229215 3492 6815365
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.575278102178499 0.301686191946967 no 2382 0.282551614386587 3429 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1022 4477-0945 21.3 µM -0.57531375375721 0.301674302365261 no 2383 0.282539560680233 3454 4648966
SGTC_1504 k297-0033 30 µM -0.577330931143157 0.301001929697674 no 2384 0.281857961268882 3315 4388117
SGTC_685 1278-0033 54.9 µM -0.577859456183349 0.30082587162712 no 2385 0.281679505007111 3532 3590572
SGTC_1700 st030840 7.9285 µM -0.578194231049304 0.300714378114797 no 2386 0.281566496600392 3482 5499307
SGTC_1666 st014829 29 µM -0.578410781965297 0.300642267873101 no 2387 0.281493408156456 3471 3858230
SGTC_1300 1094-0077 113 µM -0.580011551564574 0.300109462857982 no 2388 0.280953413955718 3448 5532636
SGTC_3101 9120531 49.47 µM -0.580110119448248 0.300076669186703 no 2389 0.280920180014976 3570 24824904
SGTC_1399 3562-5772 25 µM -0.581519514785234 0.299607938813511 no 2390 0.28044518489111 3452 23847490
SGTC_2140 5586273 200 µM -0.581735041914021 0.299536289024208 no 2391 0.280372582118645 3482 854421
SGTC_85 0868-0259 160.055 µM -0.583141876320512 0.299068792232263 no 2392 0.279898897617563 3420 83173
SGTC_578 3460-0051 92 µM -0.583793279271722 0.298852440644612 no 2393 0.279679700222457 3539 2876744
SGTC_422 cantharidin 155 µM -0.584576497759879 0.298592403133135 no 2394 0.279416257188463 3474 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1068 loratadine 26.9 µM -0.58515755150045 0.29839955314929 no 2395 0.2792208921133 3467 3957 A H1 histamine antagonist.
SGTC_2705 st078069 42.8 µM -0.58523349079601 0.298374353315079 no 2396 0.279195364293089 3452 1530061
SGTC_1958 st076513 41.9 µM -0.587400930891404 0.297655514794011 no 2397 0.27846723438817 3414 732122 YGL099W LSG1
SGTC_553 k007-0256 45.7 µM -0.59097525120286 0.296471809459038 no 2398 0.277268501764964 3485 6287000
SGTC_2924 9010168 62.78 µM -0.592862462993978 0.295847694227485 no 2399 0.276636600484775 3494 2993929
SGTC_725 1497-0963 19 µM -0.593468324589331 0.295647459250277 no 2400 0.276433887637099 3526 3549977
SGTC_3252 9135871 49.47 µM -0.594518489507607 0.295300531340884 no 2401 0.276082689748742 3533 17682838
SGTC_3214 9129694 49.47 µM -0.594568104056995 0.29528414553013 no 2402 0.27606610298975 3494 17158655
SGTC_361 000s-0510 1.45 µM -0.597699403871352 0.294250843253092 no 2403 0.275020261649651 3466 660
SGTC_323 4013-0906 34.3 µM -0.597938234661631 0.294172099727701 no 2404 0.274940573323263 3514 2910086
SGTC_1117 retinoic acid 1.10837 µM -0.59981507017298 0.293553638266635 no 2405 0.274314744336809 3563 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2765 myclobutanil 7.74 µM -0.599908551572731 0.293522849693307 no 2406 0.274283591451917 3531 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.600187139818802 0.293431104111251 no 2407 0.27419076165949 3523 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1109 tnp00067 928.257 nM -0.600240998401574 0.293413368761133 no 2408 0.274172816960038 3468 676295
SGTC_874 0599-0792 117 µM -0.602092452041387 0.292803996947731 no 2409 0.273556299267463 3567 765305
SGTC_642 0335-0876 158 µM -0.602935923671306 0.292526578772694 no 2410 0.27327565833206 3537 6812350
SGTC_3113 9123498 49.47 µM -0.604331386169755 0.292067878980123 no 2411 0.27281167167292 3557 8897275
SGTC_2340 7987427 183.45 µM -0.605142988245902 0.291801252902153 no 2412 0.27254199652396 3501 2239331
SGTC_695 3505-6186 243 µM -0.605494051970051 0.291685957214888 no 2413 0.272425387814605 3524 1819379
SGTC_2199 6590217 200 µM -0.605596617790214 0.291652276749697 no 2414 0.272391324409954 3451 703109
SGTC_70 0141-0289 43.283 µM -0.606439228040554 0.29137564985589 no 2415 0.272111563008779 3503 352408
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.606550899204212 0.29133899767427 no 2416 0.272074496944213 3562 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2879 9041815 71.43 µM -0.607382955105016 0.291065971981009 no 2417 0.271798398730204 3489 4942971
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.607416489558491 0.291054970698115 no 2418 0.271787274032804 3510 4330530
SGTC_2943 9068529 45.32 µM -0.607605925289904 0.290992828229057 no 2419 0.271724435004449 3555 3270634
SGTC_2605 digitonin 300 nM -0.60829844386328 0.290765707309432 no 2420 0.271494776467621 3597 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_775 4577-0580 57.3 µM -0.612947909441635 0.289243002302231 no 2421 0.269955391671477 3609 2006902
SGTC_2898 9056270 58.44 µM -0.613486735359445 0.289066778874341 no 2422 0.26977727545065 3481 19154699
SGTC_491 tetrandrine 80.3 µM -0.614135470705713 0.28885467650738 no 2423 0.269562905284875 3537 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1895 st058434 18.3 µM -0.614595659852719 0.288704263264124 no 2424 0.269410890690553 3571 5393175
SGTC_2892 9047358 58.44 µM -0.614653214659677 0.288685454018145 no 2425 0.269391881595995 3489 6466771
SGTC_2944 9067346 25.62 µM -0.615640551416473 0.288362876522464 no 2426 0.269065890596776 3509 6473075
SGTC_270 tamoxifen 5.46 µM -0.616405547486229 0.288113057916002 no 2427 0.268813446468727 3640 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1447 4239-0816 81.9 µM -0.617283523995125 0.287826470123431 no 2428 0.268523866151075 3476 1341554
SGTC_2714 st079313 56.9 µM -0.61785556952618 0.287639816342284 no 2429 0.268335274524054 3545 2939799
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.619671870917795 0.287047551550169 no 2430 0.267736919285984 3585 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1961 st076550 68.7 µM -0.622252664997097 0.28620699347905 no 2431 0.266887870506056 3537 1579337
SGTC_507 nimesulide 162 µM -0.622630404573278 0.286084062798902 no 2432 0.266763713153009 3601 4495 A COX2 inhibitor.
SGTC_353 1988-1175 58.3 µM -0.624017537496804 0.285632852863674 no 2433 0.266308033848579 3430 2788357
SGTC_1042 0350-0096 82 µM -0.624092573536423 0.285608454617895 no 2434 0.266283395413214 3545 3122515
SGTC_1125 tnp00248 1.32998 µM -0.627147354832799 0.284616024239904 no 2435 0.265281324209549 3592 24207736
SGTC_2754 granisetron 64.02 µM -0.628059346541841 0.284320057941972 no 2436 0.264982531706734 3576 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2211 7117706 200 µM -0.629178269254797 0.283957137936639 no 2437 0.264616176903933 3527 822771
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.630735846815438 0.283452310615898 no 2438 0.264106628166264 3599 165521
SGTC_1304 1165-0502 251 µM -0.630985759203833 0.283371351441454 no 2439 0.264024917937029 3532 767425
SGTC_1634 st006576 41 µM -0.631026889545337 0.283358028320615 no 2440 0.26401147138039 3579 3915356
SGTC_1393 3470-5649 58.2 µM -0.632120542935802 0.283003877527878 no 2441 0.263654056276474 3497 4108395
SGTC_2081 5214970 32.255 µM -0.632634183580911 0.282837621920719 no 2442 0.263486279433239 3542 2063512
SGTC_2931 9014674 55.67 µM -0.633555774970048 0.282539438145777 no 2443 0.263185385215857 3555 2996810
SGTC_1406 3909-7906 11.9 µM -0.634036678102918 0.282383900467674 no 2444 0.263028442872913 3578 X1406
SGTC_841 0251-0215 91.2 µM -0.634115138989925 0.282358527905752 no 2445 0.263002841766145 3561 3888614
SGTC_2240 6690706 185.951 µM -0.634210727920642 0.282327617985239 no 2446 0.262971653648444 3500 805876
SGTC_1208 2323-2347 50.3 µM -0.634379867923517 0.282272928360791 no 2447 0.262916472410955 3578 5412760
SGTC_2074 5212007 75.395 µM -0.634918231375666 0.282098888197988 no 2448 0.262740872944082 3531 758611
SGTC_3139 9095020 49.47 µM -0.635339049939201 0.281962883502526 no 2449 0.262603655199226 3403 25236292
SGTC_890 0929-0006 47.2 µM -0.635928306086124 0.281772494421685 no 2450 0.262411576084044 3522 1378169
SGTC_1244 0416-0015 52.5 µM -0.63662601545353 0.281547144179126 no 2451 0.262184237656143 3582 96201
SGTC_1489 4065-0444 182 µM -0.637157229979907 0.28137562772315 no 2452 0.262011216836089 3551 2877968
SGTC_1910 st062352 60.4 µM -0.638069867335501 0.281081076758121 no 2453 0.261714100273543 3536 2245730
SGTC_293 4049-0273 38.5 µM -0.639253853162941 0.280699171006774 no 2454 0.261328901771304 3519 1380311
SGTC_628 1636-0253 16 µM -0.639957858442228 0.280472206542127 no 2455 0.261099998507771 3553 4456143
SGTC_3223 9129970 49.47 µM -0.639957961462296 0.280472173335959 no 2456 0.261099965018932 3611 17248386
SGTC_1831 st055328 12 µM -0.640390298583451 0.280332836096128 no 2457 0.260959444199223 3589 1103068
SGTC_1101 ebselen 5.29 µM -0.640621152301378 0.280258448351808 no 2458 0.260884426661123 3648 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3155 9099265 49.47 µM -0.641124988174434 0.280096131076146 no 2459 0.260720740182767 3540 25236499
SGTC_1140 3229-1848 2.98 µM -0.64278590179036 0.279561369056839 no 2460 0.260181516164137 3579 2849525
SGTC_976 1348-1067 47.6 µM -0.643118055927059 0.279454485362129 no 2461 0.260073749651273 3628 5310671 YGL099W LSG1
SGTC_2589 lobaric acid 100 µM -0.643130511966382 0.279450477526284 no 2462 0.260069708770684 3546 73157 A novel microtubule depolymerizer.
SGTC_2921 7974240 10.71 µM -0.643231122791377 0.279418106167096 no 2463 0.260037070663398 3589 2979074 YDR527W RBA50
SGTC_1946 st076057 65.1 µM -0.643246087172033 0.279413291559066 no 2464 0.260032216405342 3491 953009
SGTC_1773 st048542 73.5835 µM -0.643794019092611 0.279237028863283 no 2465 0.259854506322069 3534 3237138
SGTC_999 SEC7.066 22.7 µM -0.643868713197733 0.279213004910452 no 2466 0.259830285728926 3588 740511 YDR170C SEC7
SGTC_205 1486-1330 71.903 µM -0.644567026211656 0.278988454286335 no 2467 0.25960390446886 3586 4118834
SGTC_3226 9131256 49.47 µM -0.645189278660773 0.278788435853146 no 2468 0.259402266588174 3512 17178073
SGTC_176 1486-1328 72.834 µM -0.646289395236717 0.278434982410065 no 2469 0.259045977223413 3582 22310231
SGTC_1446 4239-0190 62 µM -0.646976099658254 0.27821446377033 no 2470 0.258823705979663 3588 1340085
SGTC_2055 5235184 200 µM -0.649188138084339 0.277504700278452 no 2471 0.258108388933023 3603 2836034
SGTC_2358 9037157 4 µM -0.650534544456563 0.277073120631194 no 2472 0.257673497718883 3585 2388925
SGTC_157 1348-1695 65.819 µM -0.651582008687907 0.276737591805627 no 2473 0.257335428553711 3611 5380510
SGTC_462 ag-879 158 µM -0.65209741728157 0.27657256673053 no 2474 0.257169165045843 3607 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2009 4012297 12.05 µM -0.653143895978481 0.27623765050748 no 2475 0.256831757759637 3578 45595307
SGTC_427 1354-0053 47.3 µM -0.653629358231772 0.276082350225984 no 2476 0.256675312533572 3653 6813657
SGTC_2094 5332512 191.667 µM -0.654161358666336 0.275912211534581 no 2477 0.256503926897975 3635 755774
SGTC_2315 7733312 200 µM -0.654696933319869 0.275740981816235 no 2478 0.256331450052971 3574 726316
SGTC_1808 st050063 61.5 µM -0.656962946109075 0.275017088512757 no 2479 0.255602371139207 3605 4011993
SGTC_16 erodoxin 22.806 µM -0.657528237503843 0.274836648319413 no 2480 0.2554206602476 3631 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1422 4031-0024 15.5 µM -0.658584685753926 0.274499588080778 no 2481 0.255081249798084 3576 782427
SGTC_2678 equilin 100 µM -0.658616394983437 0.274489474392185 no 2482 0.255071066062254 3630 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_973 1325-0077 65.9 µM -0.659551668739615 0.274191250668757 no 2483 0.254770789225165 3635 2835149
SGTC_2797 7859098 81.82 µM -0.660201989216394 0.27398398222551 no 2484 0.254562107963364 3628 972681
SGTC_994 3910-0338 138 µM -0.660985720050526 0.273734296520663 no 2485 0.254310735697938 3677 3479481
SGTC_405 ebelactone b 50 µM -0.66286806774808 0.273135066976417 no 2486 0.253707527245378 3608 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2706 st078239 82.5 µM -0.66330742170556 0.272995295971668 no 2487 0.253566842132192 3631 15434492
SGTC_730 1436-0052 41.2 µM -0.663326230775245 0.272989313062626 no 2488 0.2535608202128 3635 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_687 k029-0044 34.9 µM -0.664628093626706 0.272575366243682 no 2489 0.253144197906222 3623 5829338
SGTC_564 3555-0129 330 µM -0.664807599344044 0.272518314162537 no 2490 0.253086780723033 3536 563260
SGTC_2421 5690543 90.72 µM -0.665011649400178 0.272453468385809 no 2491 0.253021521042328 3630 3397993
SGTC_1467 k284-1082 293 µM -0.665268668193473 0.272371800396191 no 2492 0.252939333399704 3606 3334705
SGTC_3254 9136651 49.47 µM -0.666077310207779 0.272114932894878 no 2493 0.252680843271999 3609 16454030
SGTC_3108 9121785 49.47 µM -0.666754143943551 0.271900027303706 no 2494 0.252464593920148 3580 17140271
SGTC_1495 4469-0029 237 µM -0.666822093627844 0.271878456851335 no 2495 0.252442889286641 3615 793680
SGTC_3076 9116187 49.47 µM -0.666891676451494 0.271856368845405 no 2496 0.252420664011428 3569 27241210
SGTC_2748 diazoxide 86.69 µM -0.668038005625469 0.271492612699154 no 2497 0.252054666376007 3561 3019 A potassium channel activatior.
SGTC_1662 st014054 52 µM -0.668148096494384 0.271457691143025 no 2498 0.252019531529714 3633 2838777
SGTC_3094 9117742 49.47 µM -0.669616390168716 0.270992152669081 no 2499 0.251551181506493 3594 17149698
SGTC_1280 0880-0253 10.1 µM -0.671874051693677 0.270277114449903 no 2500 0.250831940421587 3612 6836607
SGTC_960 1222-0186 7.7 µM -0.67400168314187 0.269604123370063 no 2501 0.250155121800924 3631 3126296
SGTC_1180 1193-0155 285 µM -0.6758080445315 0.269033412967738 no 2502 0.249581263258539 3630 2921347
SGTC_751 0833-0568 350 µM -0.680230528452508 0.267638716762138 no 2503 0.248179252501265 3681 6954252
SGTC_352 k048-0007 5.11 µM -0.681819816334358 0.267138402802987 no 2504 0.247676446159524 3631 6811911
SGTC_2906 7926292 26.41 µM -0.682050809412843 0.26706572460815 no 2505 0.247603411703733 3628 2966319
SGTC_652 0437-0092 114 µM -0.683660068313618 0.266559674829982 no 2506 0.247094922147986 3630 3091274
SGTC_1827 berberine 7.24 µM -0.684445102129751 0.266312988104887 no 2507 0.246847072010746 3584 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_412 gemfibrozil 100 µM -0.684839131150377 0.266189213143975 no 2508 0.246722719717442 3632 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1806 st050005 60.3 µM -0.685456405752502 0.26599536939578 no 2509 0.24652798042326 3639 5194765
SGTC_3349 9149703 23.001 µM -0.686400557911831 0.265699014153691 no 2510 0.24623027638139 3642 4910494
SGTC_2839 9003951 25.97 µM -0.689086304463414 0.264856914902146 no 2511 0.245384479017431 3636 2990634
SGTC_2183 6420625 130.508 µM -0.689756162832441 0.264647096521754 no 2512 0.245173770248336 3670 2897619
SGTC_1137 ixabepilone 100 µM -0.691909267311177 0.263973257048422 no 2513 0.244497155219122 3681 154225 A novel microtubule stabilizer.
SGTC_1445 4239-0156 97.7 µM -0.693088894064645 0.263604450051745 no 2514 0.244126883428565 3713 4008346
SGTC_1682 st012968 530 nM -0.694250614568444 0.263241498514554 no 2515 0.243762527960482 3651 24207270
SGTC_2583 asiatic acid 100 µM -0.694797632395619 0.263070684430231 no 2516 0.243591066079428 3690 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_776 4476-4378 112 µM -0.695009470390587 0.263004550226354 no 2517 0.243524683291772 3684 2892008
SGTC_2394 5221648 200 µM -0.696192550251855 0.262635358051488 no 2518 0.243154126238423 3734 788586
SGTC_1674 st016616 23.6 µM -0.696354081479503 0.262584971162321 no 2519 0.243103556078118 3664 625830
SGTC_682 0kpi-0099 17 µM -0.69771809809791 0.262159686988313 no 2520 0.242676753827088 3676 1714895 YML126C ERG13
SGTC_2863 9028737 58.44 µM -0.698074955435648 0.26204848138759 no 2521 0.242565159772886 3665 6460917
SGTC_1217 1183-1422 255 µM -0.698420617789613 0.261940787480063 no 2522 0.242457093041286 3714 2849664
SGTC_2860 9025725 38.96 µM -0.699021588998111 0.261753604071032 no 2523 0.242269269502922 3662 40546248
SGTC_1142 3253-1408 9.78 µM -0.699031515608437 0.261750512823983 no 2524 0.242266167768427 3657 256655
SGTC_147 4466-0538 29.23 µM -0.700726895432028 0.261222829268348 no 2525 0.241736734021189 3743 6742687 YHR072W ERG7
SGTC_2283 7944793 200 µM -0.701372240193111 0.261022110742712 no 2526 0.241535370689422 3680 2970533
SGTC_2015 5119600 184 µM -0.701930439565431 0.260848560612982 no 2527 0.241361272341853 3675 2828786
SGTC_1698 5-fluorocytosine 1.055 µM -0.702978268186329 0.260522939900904 no 2528 0.241034646367865 3701 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1805 st050013 60.3 µM -0.703222772299571 0.260446988515954 no 2529 0.240958464884965 3650 4037144
SGTC_501 nsc-95397 161 µM -0.703697006762163 0.260299707500715 no 2530 0.24081074240174 3693 262093
SGTC_2130 NSC 7 2.4545 µM -0.703904302893621 0.260235341888432 no 2531 0.240746185815663 3701 21448
SGTC_1315 1237-0019 3.69 µM -0.704129708307812 0.260165362638785 no 2532 0.240676000289109 3663 825140
SGTC_3179 9107801 49.47 µM -0.705582896069645 0.259714439660572 no 2533 0.240223781957413 3690 4818259
SGTC_2490 carminic acid 95.39 µM -0.705738003505365 0.259666333785361 no 2534 0.240175541350107 3619 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3192 9110362 49.47 µM -0.70602873602032 0.259576176792368 no 2535 0.240085133649179 3748 16649480
SGTC_2829 7992743 58.44 µM -0.706286867015843 0.259496143172321 no 2536 0.240004879438052 3695 16462845
SGTC_2112 5488546 200 µM -0.706527112675533 0.259421666359591 no 2537 0.239930199011542 3673 600757
SGTC_2692 st077426 47.7 µM -0.706697825354784 0.259368751672551 no 2538 0.239877140633465 3667 25238571
SGTC_2840 9008771 71.43 µM -0.706765444134839 0.259347793865648 no 2539 0.239856126138819 3655 2992978
SGTC_1418 3966-3099 2.4 µM -0.707634564270287 0.259078496146095 no 2540 0.239586111307197 3685 740335
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.708171835833472 0.258912094376871 no 2541 0.239419276914248 3664 77254
SGTC_137 0438-0332 85.389 µM -0.708276351140951 0.258879730706004 no 2542 0.239386830033066 3718 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1795 st049545 62.3 µM -0.709318865865307 0.258557025573512 no 2543 0.239063311792631 3643 5291882
SGTC_636 0kpi-0074 126 µM -0.709617015029493 0.258464773338118 no 2544 0.238970832662585 3706 616434
SGTC_1301 naphtanilide LB 4.81 µM -0.710052983251213 0.258329908328902 no 2545 0.238835640397023 3730 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_937 3122-0005 46.7 µM -0.710303668502882 0.258252376374578 no 2546 0.238757922698391 3682 759535
SGTC_1457 k015-0032 57.3 µM -0.711118770051369 0.258000365092998 no 2547 0.238505319735521 3690 4302660
SGTC_250 brefeldin a 552.239 µM -0.71191773227997 0.25775346758313 no 2548 0.238257860462727 3595 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_820 1582-0060 59.9 µM -0.712594413079301 0.257544453780996 no 2549 0.238048384966434 3697 3848840
SGTC_90 0870-0863 4.608 µM -0.713227919300398 0.257348855598093 no 2550 0.237852366256593 3689 1738164
SGTC_3178 9107506 49.47 µM -0.714178455627584 0.257055517681196 no 2551 0.237558418601186 3715 8897194
SGTC_1740 st038286 13.222 µM -0.715034783652977 0.256791401668908 no 2552 0.237293775097445 3712 716786
SGTC_2626 ethyl orsellinate 100 µM -0.715161142086349 0.25675244108306 no 2553 0.237254738426072 3689 75653 A natural product.
SGTC_1071 trifluoperazine 6.31 µM -0.718149818169165 0.255831828905845 no 2554 0.236332457809305 3781 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1925 st057770 10.1 µM -0.719168041345287 0.25551857606825 no 2555 0.23601869399463 3683 5989122
SGTC_2278 7948257 134.34 µM -0.720173405957691 0.255209475838735 no 2556 0.235709117869242 3669 1247028
SGTC_22 0964-0034 14.468 µM -0.720350039812853 0.255155189805242 no 2557 0.235654751162039 3694 138402
SGTC_1627 st003713 25.6 µM -0.720579149433995 0.25508478505015 no 2558 0.235584243073544 3760 16195070 YER133W GLC7
SGTC_836 0330-0104 1.35 µM -0.723136131408709 0.254299721617253 no 2559 0.234798126545707 3718 46494820
SGTC_645 0845-0943 5.41 µM -0.724189468505874 0.253976687066381 no 2560 0.234474711615674 3722 1885106
SGTC_1424 4048-1941 275 µM -0.724652174121744 0.253834853865864 no 2561 0.234332721175532 3798 X1424
SGTC_2787 5284540 71.43 µM -0.725096972845971 0.253698548872868 no 2562 0.23419627069566 3746 736958
SGTC_887 0885-0007 9.62 µM -0.725339207629862 0.253624334140142 no 2563 0.234121979067914 3762 5719458
SGTC_419 nsc-638432 893 µM -0.726160804782596 0.253372702094447 no 2564 0.233870098481737 3709 368090
SGTC_1073 triclabendazole 3.09 µM -0.728089974303743 0.252782368067094 no 2565 0.233279255312551 3801 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2773 thioridazine 9.09 µM -0.729355648954206 0.252395460043179 no 2566 0.232892069951719 3737 5452 An antipsychotic.
SGTC_2518 prenyletin 46.28 µM -0.730286324395064 0.252111158242525 no 2567 0.232607592863546 3667 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2741 miltefosine 3.04 µM -0.730528797086634 0.252037115676518 no 2568 0.232533508613835 3666 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1493 4348-0038 111 µM -0.730800396117465 0.251954192584109 no 2569 0.232450540785991 3750 800424
SGTC_1799 st045822 46.1415 µM -0.730961260706216 0.251905085100504 no 2570 0.232401407780377 3717 3674992
SGTC_1619 st003326 88.7 µM -0.730998329754066 0.251893769667712 no 2571 0.232390086569128 3676 2849032
SGTC_2476 5806916 10.51 µM -0.731753102305685 0.251663431545705 no 2572 0.232159639158146 3646 2870194
SGTC_438 sphingosine 6.67 µM -0.731966060243899 0.251598462119467 no 2573 0.232094641781122 3673 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1760 st045453 10.4495 µM -0.732403302889092 0.251465095461362 no 2574 0.231961221713743 3759 3323419 YIL048W NEO1
SGTC_140 0062-0056 502.533 µM -0.732619066427714 0.251399297575461 no 2575 0.231895399443968 3710 3758964
SGTC_381 3461-2219 42.7 µM -0.733423592176159 0.251154034733453 no 2576 0.231650057165349 3705 2883159
SGTC_3090 9117696 49.47 µM -0.733841480070896 0.251026689922633 no 2577 0.231522678238953 3687 7923821
SGTC_2447 5741742 33.78 µM -0.737215774658513 0.249999679274407 no 2578 0.230495570985118 3777 1776504
SGTC_1031 k035-0009 16 µM -0.737387033177001 0.249947614023483 no 2579 0.230443509313681 3778 5180959
SGTC_1572 epiandrosterone 68.9 µM -0.738652901621817 0.249562948881762 no 2580 0.230058896025384 3674 441302 A steroid.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.739270896544121 0.249375270299341 no 2581 0.229871259004511 3754 6708739 YPR165W RHO1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.740344393780543 0.249049438868999 no 2582 0.229545525097438 3750 5106787 A p450 inhibitor.
SGTC_1779 st039427 55 µM -0.740633572012207 0.248961705277832 no 2583 0.229457823271897 3758 1124498
SGTC_1932 st074806 40.9 µM -0.741623422964629 0.248661519603009 no 2584 0.22915776397778 3825 17251235
SGTC_606 k015-0008 38.6 µM -0.741879293585014 0.248583954748795 no 2585 0.229080236234166 3771 1970475
SGTC_87 0100-0052 35.5 µM -0.74410243918363 0.24791057120517 no 2586 0.228407251888362 3813 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2102 5377816 72.7585 µM -0.744195567205179 0.247882384292501 no 2587 0.228379084701345 3750 1379702
SGTC_2024 5144227 134 µM -0.744420631606748 0.247814271464964 no 2588 0.228311020541813 3788 3475211
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.745415954916722 0.247513169588724 no 2589 0.228010150795186 3801 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1277 0873-0036 22 µM -0.748864801858053 0.246471349882379 no 2590 0.226969348523745 3803 5965735
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.754542161364905 0.244761476793953 no 2591 0.225261869428275 3749 6708760
SGTC_2160 5660466 132.927 µM -0.755299243462437 0.244533946884419 no 2592 0.22503472625867 3705 2859134
SGTC_2523 spermine 47.74 µM -0.755462601144095 0.244484867080187 no 2593 0.224985731983396 3738 1103 A DNA binding polyamine.
SGTC_1475 4092-1048 11.7 µM -0.757527164262261 0.24386503949417 no 2594 0.224367048964946 3776 2881759
SGTC_990 3985-0011 41.3 µM -0.758596019150645 0.243544479049192 no 2595 0.22404712738127 3774 5399565 YGL099W LSG1
SGTC_401 neomycin 50 µM -0.758958727400076 0.243435750901568 no 2596 0.223938623200584 3764 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_686 1319-0111 510 µM -0.759097726027988 0.243394090581371 no 2597 0.223897049673192 3795 4562600
SGTC_234 nsc-17383 10.7 µM -0.759584199010624 0.243248316458768 no 2598 0.223751583513537 3783 408974
SGTC_367 0335-0881 7.1 µM -0.75964976733294 0.243228672184729 no 2599 0.223731981247494 3742 23828853
SGTC_581 0958-0271 211 µM -0.760091986493408 0.2430962056923 no 2600 0.223599801174019 3795 4591145
SGTC_995 3931-2021 34.6 µM -0.760855676304772 0.242867534746175 no 2601 0.223371637570008 3777 730143
SGTC_1196 1588-0294 184 µM -0.761676308677048 0.242621943333333 no 2602 0.223126609266576 3783 6144269
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.762262767484354 0.242446515682109 no 2603 0.222951595418412 3834 688788
SGTC_3095 9117207 49.47 µM -0.763130416449915 0.242187101590801 no 2604 0.22269281093025 3762 17015229
SGTC_3321 9137793 26.8275 µM -0.7633583386857 0.242118981207626 no 2605 0.222624859378593 3747 4904192
SGTC_1646 st011709 75.6 µM -0.763862894943974 0.241968218640619 no 2606 0.222474475649443 3719 5757843
SGTC_1981 st071826 47 µM -0.765745319680394 0.241406195461115 no 2607 0.221913927735889 3789 11838600
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.768855108637393 0.240479281756823 no 2608 0.220989664761799 3772 688667
SGTC_3216 9129716 49.47 µM -0.770177777252662 0.240085631170428 no 2609 0.22059722215098 3779 8056934
SGTC_542 3381-0244 89.3 µM -0.770552031036243 0.239974310134067 no 2610 0.220486251633841 3798 1112843
SGTC_981 1488-1094 54.9 µM -0.772277122283017 0.239461549284872 no 2611 0.219975156156536 3766 3449522
SGTC_2341 7987486 176.74 µM -0.772653126240848 0.239349866483304 no 2612 0.219863847175208 3797 1258686
SGTC_3342 9147791 14.508 µM -0.774177916853994 0.238897256404294 no 2613 0.219412792744955 3739 1838168
SGTC_3319 9138450 16.7555 µM -0.774434109379161 0.238821255642774 no 2614 0.219337059610057 3746 2029690
SGTC_3335 9143315 29.6265 µM -0.774454844210055 0.238815105132663 no 2615 0.219330930838808 3796 4899691
SGTC_2337 9009472 200 µM -0.775266311526804 0.238574470097941 no 2616 0.219091155808672 3783 5742383
SGTC_2025 5147754 141 µM -0.775376313672301 0.238541859938343 no 2617 0.219058663618182 3788 315777 YLR208W SEC13
SGTC_1272 0839-0021 27 µM -0.775845448972541 0.238402812074149 no 2618 0.218920122584057 3825 5027250
SGTC_539 4859-0462 2.54 µM -0.776920761797694 0.238084265675203 no 2619 0.218602760614305 3856 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_285 1486-1325 46 µM -0.777021304751858 0.238054493159676 no 2620 0.218573100460742 3805 22310230
SGTC_683 panaxydol 45 µM -0.777320984813403 0.237965764793631 no 2621 0.218484708642173 3761 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_53 0973-0023 39.979 µM -0.779164771735316 0.237420261064015 no 2622 0.217941329524369 3724 674768
SGTC_2808 7946468 45.46 µM -0.779353087335393 0.23736458458199 no 2623 0.217885875266092 3823 2970879
SGTC_2285 7945142 200 µM -0.781124620856975 0.236841172629294 no 2624 0.217364601207431 3836 2970608
SGTC_1216 1165-0504 9.65 µM -0.781322273912585 0.236782814031807 no 2625 0.217306486447328 3772 6304004
SGTC_1686 st019653 115.5 µM -0.783316439010978 0.236194463915405 no 2626 0.216720656028843 3776 97252
SGTC_975 1335-0046 28.5 µM -0.784110714758137 0.235960348541415 no 2627 0.216487574416238 3809 16486740
SGTC_2798 7813637 45.45 µM -0.785061010892931 0.235680413766313 no 2628 0.216208899028088 3807 956368
SGTC_286 k060-0067 22.9 µM -0.786271583957262 0.2353240729976 no 2629 0.215854198159232 3806 5985051
SGTC_3284 9108171 64.8615 µM -0.787028958879996 0.235101285650176 no 2630 0.215632457047463 3791 8687505
SGTC_2235 salicylic acid 500 µM -0.787573407895328 0.234941204011678 no 2631 0.215473137138381 3818 338 A COX inhibitor and kinase inhibitor.
SGTC_1687 st020778 55.3625 µM -0.789175327436193 0.234470549073787 no 2632 0.215004770100873 3817 4259299
SGTC_848 0368-0089 85.6 µM -0.790116994276271 0.234194124534954 no 2633 0.214729722971567 3816 762535
SGTC_2093 5331342 194.4 µM -0.790162201397954 0.234180858609368 no 2634 0.214716523777021 3849 33839
SGTC_88 0180-0332 8.668 µM -0.79186178666486 0.233682421196529 no 2635 0.214220635341008 3881 3101745
SGTC_2395 5646831 180.19 µM -0.79247151637978 0.233503749198167 no 2636 0.214042896866099 3816 6808628
SGTC_46 0329-0187a 2.197 µM -0.796861373020953 0.232219607681366 no 2637 0.212765773265071 3890 46494817
SGTC_2218 6965428 192.983 µM -0.797963290292711 0.231897887792352 no 2638 0.212445896711611 3760 675684
SGTC_2205 7238770 200 µM -0.798975889136677 0.231602464645288 no 2639 0.212152196362653 3863 279867
SGTC_72 0744-0168 198.391 µM -0.79919487329843 0.231538604168809 no 2640 0.21208871209325 3740 677577
SGTC_2859 9028643 45.46 µM -0.799271663870635 0.231516212716384 no 2641 0.212066452870401 3751 17151580
SGTC_618 k072-0232 33.2 µM -0.799407453905503 0.231476620496793 no 2642 0.212027094863517 3871 5872756 YGL099W LSG1
SGTC_1709 st033179 39.1045 µM -0.800398468648036 0.231187785254891 no 2643 0.211739983981692 3803 573381
SGTC_1164 k060-0068 93.7 µM -0.803670151495298 0.230235669296196 no 2644 0.210793748412485 3839 5963676
SGTC_3232 9132874 49.47 µM -0.804440966113683 0.23001166863554 no 2645 0.21057117506725 3814 3784940
SGTC_1341 1486-1360 280 µM -0.805750007789584 0.229631537427404 no 2646 0.2101935043591 3797 3976547
SGTC_2314 7727897 200 µM -0.808320530156841 0.228886111197566 no 2647 0.209453043465812 3862 900724
SGTC_2123 5259487 200 µM -0.808413941548836 0.228859048408107 no 2648 0.209426164447861 3840 2173474
SGTC_1684 st024538 14.6195 µM -0.808743065352289 0.228763710237712 no 2649 0.209331475636082 3829 6732859
SGTC_2551 apiole 73.87 µM -0.809396692415304 0.228574438467877 no 2650 0.209143502064744 3669 10659 A possible DNA adduct former.
SGTC_2399 5884133 200 µM -0.810070015100866 0.228379555412276 no 2651 0.208949968279828 3861 722445
SGTC_2164 5685496 200 µM -0.811015021253786 0.2281061952434 no 2652 0.208678522257819 3785 759046
SGTC_2616 abietic acid 100 µM -0.812933621188217 0.227551771803578 no 2653 0.208128058420394 3847 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_916 4466-0038 42 nM -0.816140805025299 0.226626679177605 no 2654 0.207209804082718 3941 5722064 YGL116W CDC20
SGTC_2129 girgensonine 121.053 µM -0.817479829634743 0.226241074733551 no 2655 0.206827135758732 3893 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3347 9188721 44.724 µM -0.818095805502088 0.226063814177613 no 2656 0.20665124189069 3901 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.818389582209103 0.225979301146952 no 2657 0.206567384226187 3808 279621
SGTC_175 3793-3120 23.7 µM -0.81911481186238 0.225770745183954 no 2658 0.206360455948767 3882 5322297
SGTC_1015 4130-4525 82 µM -0.820264302251365 0.225440406726898 no 2659 0.206032725998508 3871 1363237
SGTC_2866 9034245 58.44 µM -0.820402211827339 0.225400792915039 no 2660 0.205993427497964 3832 6462273
SGTC_1397 3532-0190 20.1 µM -0.821569634230183 0.225065614795903 no 2661 0.205660938746833 3773 5322280
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.822477874307203 0.224805045844554 no 2662 0.205402487086707 3938 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_487 nimodipine 119 µM -0.826821397612974 0.223561281202669 no 2663 0.204169150036562 3757 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2852 9023854 51.95 µM -0.828133053152217 0.223186460438708 no 2664 0.203797576216081 3950 19798528
SGTC_2543 pimpinellin 60.67 µM -0.829285248660731 0.222857502583868 no 2665 0.203471508016655 3746 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_920 mycophenolic acid 780.421 nM -0.83036063327159 0.222550724030691 no 2666 0.203167458050811 3913 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3032 9089427 49.47 µM -0.831117940660594 0.222334828993087 no 2667 0.202953502815779 3875 17173707
SGTC_540 1187-0821 17.3 µM -0.83182570807229 0.222133164988541 no 2668 0.202753665365364 3832 847520
SGTC_2237 6667747 47.222 µM -0.83269594557313 0.22188535157803 no 2669 0.202508115859768 3860 729940 YDL015C TSC13
SGTC_1194 1488-0194 225 µM -0.83306629984942 0.221779935459484 no 2670 0.202403669249557 3843 1391452
SGTC_2651 TUB2.036 5 µM -0.833724070629956 0.22159278083617 no 2671 0.202218245414196 3923 15992207 YFL037W TUB2
SGTC_2142 5622915 118.518 µM -0.836764467974283 0.220728874485456 no 2672 0.201362486797219 3902 5322196
SGTC_3318 9139014 38.6185 µM -0.838094138771512 0.220351665500126 no 2673 0.200988917248466 3872 16643984
SGTC_1768 st044301 37.178 µM -0.838311133794964 0.220290142143273 no 2674 0.200927992220633 3881 3931349
SGTC_3059 1327-0034 3 µM -0.839772084327314 0.219876183651453 no 2675 0.200518094124816 3816 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2676 harmalol 100 µM -0.840647039596751 0.219628480080786 no 2676 0.200272849012754 3846 5459187 A monoamine oxidase inhibitor
SGTC_1705 st027868 56.3335 µM -0.841726364069898 0.219323139597667 no 2677 0.199970568766283 3861 292948
SGTC_2302 7771753 200 µM -0.842049783740641 0.219231691821476 no 2678 0.199880043909721 3908 2203047
SGTC_1361 1608-0041 5.61 µM -0.843848290505853 0.218723559222602 no 2679 0.199377093330661 3846 X1361
SGTC_2977 9011197 71.43 µM -0.844581345120603 0.218516643704444 no 2680 0.199172314127961 3996 2704722
SGTC_329 k048-0121 21.3 µM -0.8452782927125 0.218320024491713 no 2681 0.198977738975087 3914 6832902
SGTC_131 0141-0277 33.849 µM -0.84547872563672 0.218263498278257 no 2682 0.198921802945854 3856 1547771
SGTC_302 1094-0063 18.9 µM -0.84792882471116 0.217573201751989 no 2683 0.1982388052433 3854 5440289
SGTC_650 1328-0195 38 µM -0.848005898279492 0.217551507329161 no 2684 0.198217342951141 3830 2780821
SGTC_704 1310-0270 142 µM -0.849084936771579 0.217247914127803 no 2685 0.197917015786608 3897 5718033
SGTC_1225 1216-0074 20.6 µM -0.849488587781648 0.217134407697206 no 2686 0.197804738887817 3904 4241466
SGTC_2139 5578692 56.4705 µM -0.849535874178348 0.217121113032135 no 2687 0.197791588534724 3829 650991 YMR113W FOL3
SGTC_2757 clomiphene 4.22 µM -0.849619388935989 0.217097633839719 no 2688 0.197768364360116 3953 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_774 k060-0086 136 µM -0.850686258900438 0.216797824988648 no 2689 0.197471829164416 3874 5911235
SGTC_2127 5253358 187.912 µM -0.852100014106749 0.216400904448862 no 2690 0.19707929207916 3836 20612
SGTC_879 0831-1030 162 µM -0.852167228339559 0.216382044115357 no 2691 0.197060641435923 3942 1549252
SGTC_2405 ticlatone 3.52 µM -0.852649825963958 0.216246655021426 no 2692 0.196926761346238 3784 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2828 7998861 71.43 µM -0.853354295185236 0.216049109617065 no 2693 0.196731429508328 3831 2988188
SGTC_2742 clothiapine 36.27 µM -0.853845189935028 0.215911516024881 no 2694 0.196595385972654 3847 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_149 3970-0822 46.1 µM -0.853950193376746 0.215882091053317 no 2695 0.196566293369327 3921 3114250 YBL034C STU1
SGTC_2298 7976326 193.81 µM -0.854806737939928 0.215642149543177 no 2696 0.196329073715085 3781 2235818
SGTC_560 2332-1943 155 µM -0.855875640752556 0.215342937681576 no 2697 0.196033285067301 3889 21177716
SGTC_1483 3453-0561 55.9 µM -0.85684907392064 0.215070659791894 no 2698 0.195764150263346 3928 4546991
SGTC_1215 3852-0577 11.2 µM -0.857724844765715 0.21482586981652 no 2699 0.195522208885301 3978 2884876
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.85865712127407 0.214565463681748 no 2700 0.195264856825733 3955 94937 An inhibitor of serotonin biosynthesis.
SGTC_3272 9137413 49.47 µM -0.859481760281728 0.214335276174354 no 2701 0.195037389402983 3859 17614870
SGTC_2531 methyl deoxycholate 70.07 µM -0.860007240395619 0.214188670027008 no 2702 0.194892525672872 3885 16667744 Haematoxylin.
SGTC_336 4111-0029 111 µM -0.862729964942616 0.213429979334744 no 2703 0.194142976605731 3916 3131175
SGTC_2186 6124449 200 µM -0.866761677512417 0.212309419340567 no 2704 0.193036301777339 3920 3834182 YLR033W RSC58
SGTC_334 1502-1024 68.5 µM -0.867812378131101 0.212017957087475 no 2705 0.192748526313213 3980 3296216
SGTC_2375 9072683 200 µM -0.868201055773434 0.211910198006374 no 2706 0.192642138189437 3941 16798029
SGTC_2820 7989630 71.43 µM -0.869451459803586 0.211563746664579 no 2707 0.192300123420586 3867 2984098
SGTC_1691 st019933 84.6 µM -0.870873712463844 0.211170084346355 no 2708 0.191911555781722 3874 6176082
SGTC_816 0325-0417 81.3 µM -0.871935364786344 0.210876511828911 no 2709 0.191621819745434 3966 68101
SGTC_385 1494-0393 12.4 µM -0.874542526502986 0.210156584953686 no 2710 0.190911435712574 3928 3090647
SGTC_1285 0929-0069 65.5 µM -0.87740462979947 0.20936792471109 no 2711 0.190133449669559 3959 1206237
SGTC_946 3434-1334 87.4 µM -0.878308684213572 0.209119172511072 no 2712 0.189888112159398 3921 4047976
SGTC_1636 st007707 68.9 µM -0.878883407542548 0.208961126870734 no 2713 0.189732248021676 3969 403051
SGTC_1980 st071811 45.7 µM -0.879881050905634 0.208686947759724 no 2714 0.189461875487103 4043 4974850
SGTC_1924 st058459 75.1 µM -0.881393475225349 0.208271697690194 no 2715 0.189052443990863 3895 688683
SGTC_2391 6285546 200 µM -0.881883709993118 0.208137203891578 no 2716 0.188919848568522 3933 846083
SGTC_2941 9056145 11.23 µM -0.883610877389986 0.207663771524826 no 2717 0.188453152583585 3804 2119517
SGTC_1148 3909-7663 27.7 µM -0.885011937352496 0.207280195981076 no 2718 0.188075096534899 4002 4084526
SGTC_1461 k072-0203 53.8 µM -0.886254311218549 0.206940415491527 no 2719 0.187740251556367 3870 5418714
SGTC_2736 butenafine 14.65 µM -0.887146280896278 0.206696671482299 no 2720 0.187500074859206 3895 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1334 1486-0610 236 µM -0.888223771010396 0.206402458073668 no 2721 0.187210197263243 4030 3742339
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.890069422329121 0.205899071830147 no 2722 0.186714305286419 4021 1273210
SGTC_900 1112-0045 141 µM -0.892140161673944 0.205335162498316 no 2723 0.186158905300934 3853 56211 YIL048W NEO1
SGTC_1167 k781-0610 148 µM -0.894498417585383 0.204694074437559 no 2724 0.185527638025264 3981 4525169
SGTC_3197 9113331 49.47 µM -0.895094724403142 0.204532158190422 no 2725 0.185368226934583 3982 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1246 0422-0085 105 µM -0.895424045759674 0.204442769657698 no 2726 0.185280225701717 4003 264295
SGTC_3132 9126706 49.47 µM -0.895446968550478 0.204436548532046 no 2727 0.185274101240792 4049 850858
SGTC_2159 5658611 73.75 µM -0.897383597735435 0.203911364483146 no 2728 0.184757130921462 3930 793844
SGTC_558 k064-0027 21.3 µM -0.897701942956383 0.203825111164973 no 2729 0.184672236672838 3989 5088526
SGTC_3013 9080133 71.4286 µM -0.898257449167999 0.203674652897276 no 2730 0.184524155959118 4067 17050193
SGTC_503 tyrphostin 8 294 µM -0.89912924058612 0.203438662675554 no 2731 0.184291912365683 3957 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_253 dyclonine 31.25 µM -0.899447936199319 0.203352433863224 no 2732 0.184207057872896 4047 3180 An oral anasthetic.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.899940612777082 0.20321917430595 no 2733 0.184075927833107 4008 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1555 citronellol 128 µM -0.900520015266113 0.203062523766154 no 2734 0.183921789335062 3891 8842 A terpine precursor.
SGTC_630 4356-0227 183 µM -0.900815773277631 0.202982588757322 no 2735 0.183843139799094 3944 779312
SGTC_765 1319-0117 244 µM -0.902097212885076 0.202636469097816 no 2736 0.183502614654909 3924 3487746 YGL099W LSG1
SGTC_55 0767-0285 6.563 µM -0.902435668115047 0.202545110515099 no 2737 0.183412740454021 3891 3116166
SGTC_506 n9-isopropylolomoucine 153 µM -0.903325509315098 0.202305034851128 no 2738 0.183176580864834 3977 6610355
SGTC_655 k060-0012 42 µM -0.905502870940903 0.201718309435969 no 2739 0.182599519809172 3968 5994525
SGTC_3209 9113616 49.47 µM -0.906087781568325 0.201560869604824 no 2740 0.18244469597147 4019 16649353
SGTC_1079 idarubicin 2.36 µM -0.906215349563737 0.201526542031979 no 2741 0.182410940056627 3981 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_321 4534-3890 65.3 µM -0.906411621365609 0.201473733631076 no 2742 0.182359011968419 3991 699746
SGTC_3176 9106582 49.47 µM -0.907593813554164 0.20115583138515 no 2743 0.182046432019641 3908 17018027
SGTC_292 k038-0015 474 µM -0.907897305048301 0.201074268307645 no 2744 0.181966240798235 3975 46368540
SGTC_2751 anetholtrithion 17.25 µM -0.907940734161875 0.201062598393341 no 2745 0.181954767378536 4009 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1629 st005085 44.9 µM -0.90802296601416 0.20104050283902 no 2746 0.181933044007851 3947 24207091
SGTC_969 1313-0238 134 µM -0.908363847168081 0.200948924205689 no 2747 0.181843009976195 4001 5212874
SGTC_1999 st074831 12.5 µM -0.908549356662825 0.200899097101978 no 2748 0.181794024647784 3934 17112523
SGTC_563 tetrahydrosecaminediol 614 µM -0.908946807942339 0.200792368246853 no 2749 0.181689102115884 4055 334274 A psychoactive constituent of the cannabis plant.
SGTC_3292 9120825 59.784 µM -0.909337064820614 0.200687604445448 no 2750 0.181586115697416 3966 24824900
SGTC_2805 7950783 58.44 µM -0.909851623537332 0.200549522191097 no 2751 0.181450382632095 4008 1178958 YDL195W SEC31
SGTC_3227 9130768 49.47 µM -0.910532732885197 0.200366833702859 no 2752 0.181270813651763 4005 17720899
SGTC_1398 3558-0053 112 µM -0.911596451397688 0.200081721102268 no 2753 0.180990595561937 3880 4532369
SGTC_885 0865-0106 16.8 µM -0.913176372427548 0.199658699139932 no 2754 0.180574894204899 3898 2793380
SGTC_2495 cafestol 54.53 µM -0.915032360404807 0.199162448593005 no 2755 0.180087320980817 4014 16667697 An anti-infammatory.
SGTC_477 mead ethanolamide 10 µM -0.916769160638718 0.198698739841689 no 2756 0.179631808052849 3875 16061185
SGTC_809 3998-0021 90 µM -0.918478703208523 0.198242944989625 no 2757 0.179184151767381 3945 715485
SGTC_2796 7949634 45.45 µM -0.918712181232207 0.198180744560591 no 2758 0.179123068337731 3937 2971588
SGTC_2988 9073640 71.4286 µM -0.920455842727046 0.197716591728681 no 2759 0.178667299129848 4061 9102229
SGTC_749 1000-0129 128 µM -0.922646124606968 0.197134482884434 no 2760 0.178095825205369 4061 708470
SGTC_1794 st048918 76.9 µM -0.92320060091208 0.196987284977018 no 2761 0.177951337882597 3883 672303
SGTC_3089 9117425 49.47 µM -0.924085150432465 0.196752599658285 no 2762 0.177720992031477 3989 9401657
SGTC_839 0122-0028 230 µM -0.92429387243703 0.196697247030877 no 2763 0.177666666104753 3984 759448
SGTC_2048 5246248 200 µM -0.924675649687878 0.196596024931665 no 2764 0.177567324669769 3999 677046
SGTC_522 1273-0010 11.6 µM -0.924719017837941 0.196584528560373 no 2765 0.177556042154687 4119 5705015
SGTC_81 0411-0046 9.971 µM -0.926862113590715 0.196016927321645 no 2766 0.176999065108262 3924 12925265
SGTC_287 k060-0039 29.6 µM -0.928885948754094 0.195481826105098 no 2767 0.176474097836958 4057 5861974
SGTC_955 1216-0110 33 µM -0.929338680304359 0.195362245600879 no 2768 0.17635679769514 3975 3619719
SGTC_1257 0669-0121 16 µM -0.929508077996366 0.195317513820774 no 2769 0.176312920412107 4017 4307855
SGTC_1974 st069448 26.9 µM -0.933503621508006 0.194264241007025 no 2770 0.17528000074278 3986 6323587 YNR016C ACC1
SGTC_875 0709-0210 25.7 µM -0.934312450201002 0.194051445866714 no 2771 0.175071371963567 4015 6251364
SGTC_1540 guanosine 70.6 µM -0.936585509483976 0.193454186355538 no 2772 0.174485904302879 3899 6802 Guanosine is a purine nucleoside
SGTC_1973 st070275 50.2 µM -0.937608766674915 0.193185686039975 no 2773 0.174222752232018 3952 17118334
SGTC_3334 9142812 21.919 µM -0.938418768407914 0.192973304850579 no 2774 0.174014622221161 4038 45283678
SGTC_3105 9121040 49.47 µM -0.939247905488395 0.192756054147047 no 2775 0.173801739173263 3834 41448907
SGTC_863 0466-0191 129 µM -0.940005854381828 0.192557586988584 no 2776 0.173607278861871 4050 765160 YPR165W RHO1
SGTC_3055 9094636 49.47 µM -0.941473106531483 0.192173745523803 no 2777 0.173231232395712 4042 25236176
SGTC_2809 7964133 12.99 µM -0.941911060957813 0.192059264940888 no 2778 0.173119088331642 4032 1253665
SGTC_1050 3232-1156 69.3 µM -0.942609043679572 0.191876899654877 no 2779 0.17294045615547 3991 700529
SGTC_2059 5238311 157 µM -0.942876785384914 0.191806973637331 no 2780 0.172871965172937 4013 703021
SGTC_654 1124-0271 80.9 µM -0.942902455250599 0.191800270266277 no 2781 0.172865399475018 4018 5403748
SGTC_2923 7992654 58.14 µM -0.944355005193483 0.191421188368487 no 2782 0.17249413312146 4035 2985126
SGTC_1610 st001799 48.1 µM -0.945044784315684 0.191241332879509 no 2783 0.17231800636329 3930 621897
SGTC_1173 0443-0020 122 µM -0.945810808082269 0.191041718533773 no 2784 0.172122545963279 4019 5331295
SGTC_1500 4488-1866 171 µM -0.946096494279899 0.190967305705816 no 2785 0.172049685852742 4092 2900003
SGTC_1066 ketoconazole 628 nM -0.948321362150046 0.190388401804554 no 2786 0.171482939486734 4098 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1222 0366-0074 1.18 µM -0.949589473661285 0.190058925764801 no 2787 0.171160444580564 4050 286520
SGTC_273 hydroxyurea 18.1 mM -0.949712208269098 0.19002705592311 no 2788 0.171129252399045 4105 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_878 0828-0289 13.7 µM -0.950045114993891 0.189940628346452 no 2789 0.171044664681325 3985 745350 YLR208W SEC13
SGTC_702 1488-0190 94 µM -0.950555062055207 0.18980828531183 no 2790 0.170915144947328 4078 949357
SGTC_1717 st033143 58.0435 µM -0.952472513603907 0.189311170014768 no 2791 0.170428699640754 4096 674616
SGTC_2373 9071805 200 µM -0.954247599144756 0.188851679426567 no 2792 0.169979162872328 4023 10149009
SGTC_1594 piperine 70.1 µM -0.95720105430762 0.188088685947949 no 2793 0.169232892512945 4013 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2030 5175110 200 µM -0.95774111334759 0.187949373529579 no 2794 0.169096659807298 4080 2831986
SGTC_1750 st081859 2.357 µM -0.957766881548011 0.187942728015151 no 2795 0.169090161405322 3995 5291695
SGTC_3116 9124943 49.47 µM -0.957793443344527 0.187935877987354 no 2796 0.169083463036688 4026 41905195 YPL160W CDC60
SGTC_2784 7567673 72.73 µM -0.962718275464729 0.186668476815709 no 2797 0.16784446140811 4024 3471247
SGTC_805 3852-0218 479 µM -0.963759893289735 0.186401096888322 no 2798 0.16758315934159 3995 6615355
SGTC_2196 6573537 42.6665 µM -0.964411957702989 0.186233834870887 no 2799 0.167419714760376 4072 2903087
SGTC_1696 st025591 34.7925 µM -0.964555402514474 0.186197052112179 no 2800 0.167383773086502 4052 2787147
SGTC_620 0109-0052 432 µM -0.964734571350233 0.186151115164023 no 2801 0.167338887350117 4039 493037
SGTC_691 1548-0686 185 µM -0.965822092333863 0.185872437303879 no 2802 0.167066605867831 4039 46495133
SGTC_458 nppb 133 µM -0.969394254393441 0.184958890783058 no 2803 0.166174258971047 4069 4549 A chloride channel blocker.
SGTC_33 0986-0033 35.816 µM -0.971263244011571 0.184482028118572 no 2804 0.165708603620129 3987 2848082
SGTC_2594 a-mangostin 100 µM -0.971452715115576 0.184433728312453 no 2805 0.165661444386178 4088 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2443 5493264 126.67 µM -0.973138488063883 0.184004338983263 no 2806 0.165242238760678 4088 5340055
SGTC_917 harmaline 728.087 nM -0.973489355610765 0.183915046559502 no 2807 0.165155073988175 4042 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_272 doxorubicin 8.13 µM -0.97626106035818 0.183210623173341 no 2808 0.164467555681208 4048 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3188 9110789 49.47 µM -0.97795354448352 0.182781310232846 no 2809 0.164048650437156 4050 849217
SGTC_1564 D-Arginine 115 µM -0.97795572369982 0.182780757861297 no 2810 0.164048111507837 4079 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2292 7671323 168.05 µM -0.978673114381593 0.182598975641965 no 2811 0.163870760211487 4134 937504
SGTC_1138 3761-0006 1.03 µM -0.978981814786566 0.182520787686064 no 2812 0.163794482474943 4074 12061087
SGTC_1856 st057054 55.7 µM -0.979368677830882 0.18242283214502 no 2813 0.163698923831663 4099 1266018
SGTC_452 diindolylmethane 8 µM -0.981820059807675 0.181802894356502 no 2814 0.163094251920243 4072 3071 Inhibits expression of several cancer promoting factors.
SGTC_1039 k821-0043 94 µM -0.982432383351958 0.181648247853292 no 2815 0.162943439574789 4097 15992768
SGTC_348 k064-0012 10.7 µM -0.98274006010025 0.181570573065355 no 2816 0.162867694506407 3973 5066323
SGTC_2493 resveratrol 26.09 µM -0.98476489553218 0.181059910250987 no 2817 0.162369783827885 3951 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2764 methyldopa 94.69 µM -0.98525841621812 0.180935581018008 no 2818 0.162248576533056 4068 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_212 3807-4682 38.772 µM -0.986011590790355 0.180745942146927 no 2819 0.162063712550983 4136 3125501 YBL034C STU1
SGTC_96 0929-0093 37.281 µM -0.990101015445797 0.179718458294905 no 2820 0.161062373545012 4068 6991579
SGTC_1650 st011916 45.8 µM -0.993248267954597 0.178930202970939 no 2821 0.160294490609168 3985 242528
SGTC_2629 bisabolol 100 µM -0.993830483571178 0.178784621109147 no 2822 0.160152701320156 4122 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_871 0574-0004 149 µM -0.994630558962333 0.17858468551873 no 2823 0.15995798956935 4057 9551173
SGTC_274 sirtinol 40.1 µM -0.996455741815398 0.178129107001669 no 2824 0.159514380438904 4151 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_159 3970-0959 50 µM -1.00049147269439 0.177124363775392 no 2825 0.158536361150971 4167 6615653
SGTC_2097 5376186 200 µM -1.00153705682364 0.176864638203507 no 2826 0.158283617011304 4062 742755
SGTC_716 1683-5115 658 µM -1.00490721380163 0.176029122624085 no 2827 0.157470765258759 4019 723597
SGTC_1018 4259-0013 28.1 µM -1.00849141837402 0.175143288120872 no 2828 0.156609302721709 4160 6801262
SGTC_2342 7990637 118.86 µM -1.00857650175474 0.175122294218237 no 2829 0.156588890724676 4157 2033102 YER133W GLC7
SGTC_1645 Cervolide 78 µM -1.00926393937642 0.174952730944946 no 2830 0.156424034693493 4077 23173 A fragrance.
SGTC_2318 6029776 164 µM -1.0125814101644 0.174135909205096 no 2831 0.155630071495196 4142 818325
SGTC_1087 pterostilbene 9.05 µM -1.01298240105741 0.174037342404848 no 2832 0.155534283574415 4153 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3071 9117417 49.47 µM -1.01300017559342 0.174032974101448 no 2833 0.155530038528382 4055 45595590 YGL055W OLE1
SGTC_2659 sanguinarine 24.21 µM -1.01363322837501 0.173877439311942 no 2834 0.15537889802353 4041 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1969 st069479 40.1 µM -1.01546942739872 0.173426803668462 no 2835 0.154941056407179 4110 3895485
SGTC_485 niflumic acid 177 µM -1.01675481916225 0.173111788611263 no 2836 0.154635040106509 4167 4488 A COX2 inhibitor.
SGTC_3287 9117173 37.0625 µM -1.01729396576349 0.172979766798239 no 2837 0.154506803162065 4092 2789709
SGTC_1252 0493-0875 34.8 µM -1.01733756588059 0.172969093162207 no 2838 0.154496435872459 4102 3960963
SGTC_1824 st053723 68.6 µM -1.01788793859758 0.172834393871171 no 2839 0.154365607108021 4141 675225
SGTC_2980 9014342 25.29 µM -1.01845455328264 0.172695789349089 no 2840 0.154230994022654 4172 2996599
SGTC_2041 5107442 45.335 µM -1.01979456001606 0.172368280739274 no 2841 0.153912951861392 4161 793005
SGTC_478 N-arachidonylglycine 10 µM -1.02389221916255 0.171369239534558 no 2842 0.152943092870194 4063 5283389
SGTC_1893 st059353 36.1 µM -1.02431294828332 0.17126687244167 no 2843 0.1528437420103 4127 3112488
SGTC_745 0469-0705 296 µM -1.02443816185148 0.171236414430631 no 2844 0.152814182378126 4186 3486736
SGTC_1724 st037281 8.293 µM -1.02559304128333 0.170955655055724 no 2845 0.152541724450709 4085 574124 YDL195W SEC31
SGTC_2336 9001819 198.65 µM -1.02658595872019 0.170714505373918 no 2846 0.152307734269604 4193 2989602
SGTC_3195 9113082 49.47 µM -1.02677275182268 0.170669163311193 no 2847 0.15226374138892 4094 17018038
SGTC_57 miconazole 162.5 nM -1.02897399437953 0.170135415613635 no 2848 0.151745947678185 4020 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1749 st037932 54.2 µM -1.03148844248901 0.169527033503674 no 2849 0.15115591264104 4167 594497
SGTC_2670 beta-carotene 100 µM -1.03201445441707 0.169399939296126 no 2850 0.151032673114586 4053 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1401 3807-4679 7.6 µM -1.0338205787605 0.16896401186119 no 2851 0.150610024658834 4074 3291456
SGTC_2602 kawain 100 µM -1.03510429919158 0.168654610693061 no 2852 0.15031010251197 4132 5369129
SGTC_168 3970-0862 530.542 µM -1.03597479884137 0.16844501096313 no 2853 0.15010694984566 4094 3135186
SGTC_3048 9093155 49.47 µM -1.0374246573112 0.168096284651205 no 2854 0.149768995932737 4095 25236002
SGTC_333 3486-0131 40.1 µM -1.03757865401024 0.168059272001968 no 2855 0.149733130003753 4171 6744690
SGTC_2246 7293507 91.5585 µM -1.042401684391 0.166902725751654 no 2856 0.14861274294917 4185 887656
SGTC_625 k213-0058 121 µM -1.0429523739159 0.166770999602447 no 2857 0.148485175536844 4196 3655420
SGTC_3253 9135987 49.47 µM -1.04355463300619 0.166627014714222 no 2858 0.148345745873714 4149 4182430
SGTC_2174 5790901 200 µM -1.04541570277665 0.166182587270864 no 2859 0.147915441160231 4146 786020
SGTC_2909 7941780 10.49 µM -1.04978181297962 0.165142959131912 no 2860 0.146909219420678 4119 1243215
SGTC_1614 st002383 48.6 µM -1.05220520453765 0.164567738624146 no 2861 0.146352706091111 4154 1947235
SGTC_580 1123-0028 41 µM -1.05228158075511 0.164549630960825 no 2862 0.146335189916002 4186 1677248 YPR107C YTH1
SGTC_529 4076-0302 30.3 µM -1.05257314959571 0.164480516206559 no 2863 0.146268334258787 4098 5816522
SGTC_356 1634-0012 32.5 µM -1.05464770800548 0.163989297121527 no 2864 0.145793237914213 4158 735457
SGTC_637 1181-0519 7.26 µM -1.05478557464794 0.163956686478701 no 2865 0.145761701757206 4134 6252091 YGR060W ERG25
SGTC_1061 3448-9325 110 µM -1.05756404735213 0.163300370233299 no 2866 0.145127120364778 4082 723482
SGTC_2918 7977171 22.06 µM -1.05765608547045 0.163278658718984 no 2867 0.145106131443058 4137 2236483
SGTC_928 2764-0428 58.7 µM -1.05849604247045 0.163080602063616 no 2868 0.144914677037004 4178 662578
SGTC_2827 7993847 71.43 µM -1.05879183179971 0.163010893964549 no 2869 0.144847297224865 4223 2985692
SGTC_2700 st077718 96.8 µM -1.05950718891054 0.162842387218936 no 2870 0.14468442850113 4142 904970
SGTC_1618 st003135 44.5 µM -1.06226632931851 0.162193516201313 no 2871 0.144057397732263 4114 1270615
SGTC_1403 3909-7815 62.9 µM -1.0633761785961 0.161932986786315 no 2872 0.143805695577324 4114 6615483
SGTC_1240 0356-0016 42.1 µM -1.06454046549856 0.161659971691643 no 2873 0.143541966620666 4134 4305613
SGTC_2954 9074818 52.69 µM -1.06655280659911 0.16118880314276 no 2874 0.14308691051397 4193 16648742
SGTC_865 0488-0499 301 µM -1.06771812154242 0.160916366922015 no 2875 0.142823840793899 4128 9634651
SGTC_217 ketoconazole 989 nM -1.06784643216213 0.160886387866726 no 2876 0.142794894678491 4008 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2638 epoxomicin 18 µM -1.06921941482732 0.16056582644021 no 2877 0.142485406172581 4141 9915668 A protesome inhibitor.
SGTC_3153 9100258 49.47 µM -1.07180520108124 0.159963235492182 no 2878 0.141903768261886 4109 25236848
SGTC_2553 4-methylesculetin 85.09 µM -1.07199332708631 0.159919452447666 no 2879 0.141861514667309 4192 5319502
SGTC_761 k216-0224 480 µM -1.07427509920923 0.159389033932229 no 2880 0.141349700990198 4206 1340404
SGTC_1575 cyproterone acetate 48 µM -1.07479633473444 0.159268029833176 no 2881 0.141232960905142 4174 9880 An androgen receptor antagonist and liver toxin.
SGTC_3307 9126885 69.2785 µM -1.07509216440166 0.159199380157723 no 2882 0.14116673360693 4141 24824909
SGTC_1465 k213-0056 144 µM -1.07574722659464 0.159047436641685 no 2883 0.141020159977658 4043 24048857 YMR208W ERG12
SGTC_1832 st054113 55 µM -1.0760843082563 0.158969286640404 no 2884 0.140944776409773 4171 1251267
SGTC_1224 0823-0416 294 µM -1.07695315946198 0.158767965665257 no 2885 0.140750596118207 4244 3598164
SGTC_2810 7959871 45.46 µM -1.0774823271011 0.15864543448766 no 2886 0.140632420983655 4139 2974535
SGTC_306 1672-3436 11.6 µM -1.07812060086375 0.158497721812393 no 2887 0.140489969602299 4217 6797378
SGTC_430 0958-0115 16.4 µM -1.07832791208761 0.158449764171017 no 2888 0.140443722497896 4124 6833180
SGTC_1120 ficusin 1.78878 µM -1.0791279302906 0.158264783911976 no 2889 0.140265350902589 4221 6199 A DNA cross-linker.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.08144566946632 0.157729676379865 no 2890 0.139749457987271 4208 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_744 1594-0068 283 µM -1.08364272747648 0.157223529591788 no 2891 0.139261619195356 4146 668392
SGTC_3075 9116269 49.47 µM -1.08596358958428 0.156690022644854 no 2892 0.138747550680518 4214 17015205 YNL244C SUI1
SGTC_2964 9083345 53.42 µM -1.09106279913306 0.155522034454377 no 2893 0.137622625286295 4181 17741579
SGTC_3230 9131665 49.47 µM -1.0921153243361 0.15528166758334 no 2894 0.137391207275226 4156 15943720
SGTC_2835 9006588 71.43 µM -1.09300047835536 0.155079713447256 no 2895 0.137196794860422 4248 2345538
SGTC_443 clozapine 122 µM -1.09345772431204 0.154975457517552 no 2896 0.137096440454579 4135 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_25 0118-0223 35.662 µM -1.09558680280825 0.154490619356713 no 2897 0.136629819836895 4182 5333628
SGTC_3126 9127922 49.47 µM -1.09624155170604 0.154341720383672 no 2898 0.136486540041692 4238 45595682
SGTC_889 0919-1524 82.7 µM -1.09967367604369 0.15356276059543 no 2899 0.135737164090119 4218 3905452
SGTC_2269 7935389 174.42 µM -1.10189184170217 0.153060709995477 no 2900 0.135254347900017 4165 97605
SGTC_951 1171-0579 82.7 µM -1.10213453190631 0.153005846587525 no 2901 0.135201594370242 4145 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_767 0929-0023 86 µM -1.10464739366065 0.152438546542301 no 2902 0.134656203222526 4204 1204563
SGTC_2506 ethyl hematommate 54.16 µM -1.10667641989861 0.151981496421955 no 2903 0.134216926900535 4270 3940691 An allergen.
SGTC_2745 rifampicin 24.3 µM -1.10762596508094 0.151767918757981 no 2904 0.134011692507163 4250 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2151 5563267 85.4165 µM -1.11219005647723 0.15074411907664 no 2905 0.133028221155801 4249 5310824
SGTC_1757 st041620 31.8375 µM -1.11389812315797 0.150362157259067 no 2906 0.132661447345727 4273 5289815
SGTC_1430 4049-0248 69.1 µM -1.11463039739402 0.150198602072251 no 2907 0.132504419345546 4216 22774488
SGTC_1201 1889-3372 45.9 µM -1.11601176790255 0.149890392633762 no 2908 0.132208548704607 4081 5392199
SGTC_424 splitomicin 100 mM -1.11784362041079 0.14948232327304 no 2909 0.131816893920968 4268 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1113 artemisinin 1.17947 µM -1.11906309160628 0.14921108143001 no 2910 0.131556612059861 4244 2240 An anti-malaria and mitochondrial poison.
SGTC_727 3032-0951 202 µM -1.12001958612132 0.148998562519782 no 2911 0.131352707890344 4248 3652836
SGTC_646 4092-0839 27.3 µM -1.1200340422849 0.148995352126365 no 2912 0.131349627820409 4241 877796
SGTC_2103 5378138 10 µM -1.12107264037211 0.148764823440076 no 2913 0.131128471745712 4275 244142
SGTC_1253 0550-0034 176 µM -1.12162340798834 0.148642671067287 no 2914 0.131011297307957 4245 5969915
SGTC_1559 coumarin 343 70.1 µM -1.12307526308113 0.148320991813781 no 2915 0.130702765523781 4242 108770 A hepatotoxic, DNA x-linker.
SGTC_1788 fluconazole 20 µM -1.12347068590515 0.148233460979309 no 2916 0.130618821850828 4253 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1365 1672-3266 55.4 µM -1.12800035967857 0.14723323759769 no 2917 0.129659883619983 4238 6415873
SGTC_1868 st057644 42.7 µM -1.12862212931662 0.147096295005315 no 2918 0.129528635706212 4243 688665
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.13232108221432 0.146283379164169 no 2919 0.128749734935432 4212 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_247 mechlorethamine 29.705 µM -1.13293170360215 0.146149474073987 no 2920 0.128621467515151 4129 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2896 9052656 71.43 µM -1.13318537347239 0.146093870221643 no 2921 0.128568207581221 4018 6469436
SGTC_1591 genipin 88.4 µM -1.13393387528379 0.145929883185983 no 2922 0.128411143106772 4260 442424 A DNA cross-linking agent.
SGTC_2029 5175081 200 µM -1.13402278732318 0.145910411934003 no 2923 0.128392494795406 4194 1380876
SGTC_535 2293-4129 48.2 µM -1.13493972781119 0.145709708810756 no 2924 0.128200286398004 4226 396118 YIL048W NEO1
SGTC_1906 st060206 94.7 µM -1.13738477251303 0.145175436528878 no 2925 0.127688735087269 4250 5133468
SGTC_365 0121-0052 13.6 µM -1.13907430772144 0.144807023492247 no 2926 0.127336081228982 4251 3101739
SGTC_1789 tunicamycin 25 nM -1.13975460694274 0.144658858210214 no 2927 0.127194274998385 4128 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_827 3253-0474 693 µM -1.1410160868714 0.144384385416622 no 2928 0.126931614327522 4260 5402065
SGTC_1261 0712-0010 12.7 µM -1.14279442023111 0.143998052149878 no 2929 0.126561978011454 4249 2840123
SGTC_2708 st078559 56 µM -1.14538083370947 0.143437413262928 no 2930 0.126025717140907 4170 17250902
SGTC_59 0330-0160 1.33 µM -1.1486021471748 0.142741214802359 no 2931 0.125360035641171 4197 4293482
SGTC_2435 5706476 10.6 µM -1.14873814272098 0.142711873441062 no 2932 0.125331986386712 4224 5725375
SGTC_2396 5342950 42.78 µM -1.14966130166204 0.142512807501079 no 2933 0.125141699493495 4214 1886677
SGTC_26 0302-0163 425.158 µM -1.15115727410147 0.142190621482462 no 2934 0.124833769498655 4303 3100915
SGTC_2915 7971052 15.16 µM -1.1519391229415 0.14202243179467 no 2935 0.124673045070678 4146 5741558
SGTC_2999 9069765 71.4286 µM -1.15225499479016 0.141954520313638 no 2936 0.124608152428815 4201 2097066
SGTC_1096 rimcazole 32.2 µM -1.15244204845863 0.141914314713592 no 2937 0.124569735297716 4157 18528119 A dopamine reuptake inhibitor.
SGTC_505 gw-5074 63.9 µM -1.15540764809569 0.14127791431439 no 2938 0.123961765722466 4273 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_851 0394-0702 453 µM -1.15616279830161 0.141116172992703 no 2939 0.123807286684369 4252 762646
SGTC_1590 st077108 57.8 µM -1.15768443743667 0.140790643315436 no 2940 0.12349641856095 4264 5489485
SGTC_1220 1838-0075 193 µM -1.15850378873354 0.140615567786037 no 2941 0.123329253215561 4155 5529645
SGTC_2505 galangin 7.89 µM -1.16248324631184 0.139767356263604 no 2942 0.122519613060766 4154 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2703 st077852 53.4 µM -1.16291131744495 0.13967632160409 no 2943 0.122432742572798 4282 6281836
SGTC_3242 9133940 49.47 µM -1.16489087180817 0.139255869057681 no 2944 0.122031584448329 4263 17248444
SGTC_2982 9019404 25.97 µM -1.16903364182097 0.138378744256828 no 2945 0.121195038708113 4200 22333232
SGTC_2114 5491910 81.25 µM -1.17136018630475 0.137887813025944 no 2946 0.120727014260599 4315 2849228
SGTC_468 gf-109203x 121 µM -1.17209634543414 0.137732721610378 no 2947 0.120579188510717 4267 2396 A protein kinase C inhibitor.
SGTC_1281 0884-0031 11.8 µM -1.17596114089295 0.136920453388574 no 2948 0.119805202348156 4280 1548255
SGTC_1233 0325-0408 14.2 µM -1.17766750742639 0.136562868388487 no 2949 0.119464592701179 4287 12874
SGTC_1917 st066507 28.5 µM -1.1795340015728 0.136172459125704 no 2950 0.119092802835954 4214 3156428
SGTC_163 TUB2.036 7.546 µM -1.17985421805745 0.136105557195722 no 2951 0.119029100600611 4237 15992207 YJR013W GPI14
SGTC_58 0957-0393 9 µM -1.18252309708614 0.135548830975604 no 2952 0.118499103208762 3978 6997992
SGTC_3093 9117344 49.47 µM -1.18547047508416 0.134935825385118 no 2953 0.117915740778537 4296 24824913
SGTC_179 1273-0063 6.77 µM -1.18781519679554 0.134449522384497 no 2954 0.117453112928673 4231 3108139
SGTC_1271 0832-2808 169 µM -1.18858056427586 0.134291043463761 no 2955 0.117302379868325 4310 3663794
SGTC_206 4546-0025 72.014 µM -1.18909185759113 0.134185245284812 no 2956 0.117201761067103 4326 6620745 YIL048W NEO1
SGTC_977 1348-1378 135 µM -1.18923055717491 0.1341565550712 no 2957 0.117174476544467 4267 X977
SGTC_45 0kpi-0036 14.9 µM -1.19018682798627 0.133958863721887 no 2958 0.116986484575352 4307 2795021
SGTC_3083 9117465 49.47 µM -1.19323149127375 0.133330769535886 no 2959 0.116389362326892 4269 16420915
SGTC_2642 cholecalciferol 100 µM -1.19636913010758 0.132685618007258 no 2960 0.115776271199317 4267 9821465 A vitamin D precursor, similar to steriods.
SGTC_2891 9063876 19.48 µM -1.1968061863606 0.132595922768077 no 2961 0.115691053225612 4297 6472478
SGTC_3031 9088762 49.47 µM -1.19756578704847 0.132440132479619 no 2962 0.115543051013799 4249 205253
SGTC_1744 st037937 38.9 µM -1.20138836407244 0.131658055947565 no 2963 0.114800293823993 4337 1016152
SGTC_376 3970-0862 59.1 µM -1.20527156138262 0.130866846103422 no 2964 0.114049242199076 4325 3135186
SGTC_755 1995-0008 37.3 µM -1.20634975471157 0.1306477459526 no 2965 0.113841330411191 4258 689533
SGTC_467 ro 31-8220 72.8 µM -1.2091929098615 0.130071203724317 no 2966 0.113294370501486 4233 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2657 nystatin 74.44 µM -1.21085046305988 0.129735894603799 no 2967 0.112976360416465 4330 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2800 7887935 81.82 µM -1.21295515159447 0.129310997024695 no 2968 0.112573483894977 4287 2961002
SGTC_2255 7941087 197.44 µM -1.21323082634426 0.129255414924184 no 2969 0.112520790722305 4409 935561
SGTC_746 1095-0025 46.6 µM -1.21555695268048 0.128787075993482 no 2970 0.112076870458273 4311 6749286
SGTC_2412 st077135 33.4 µM -1.21750423729379 0.128395918799143 no 2971 0.111706212618061 4353 13258915
SGTC_2248 tofa 1.1 µM -1.21923407866236 0.128049132533712 no 2972 0.111377680431523 4292 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_771 0250-0039 27.3 µM -1.21972542646356 0.12795074939285 no 2973 0.111284489700144 4261 3005115
SGTC_1665 st014639 11.4 µM -1.22265528844157 0.127365190042765 no 2974 0.110729960596124 4372 981133 YIL048W NEO1
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.22376123292137 0.127144642379231 no 2975 0.110521156337958 4406 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_413 propylparaben 100 µM -1.22477338903132 0.126943031020926 no 2976 0.110330306990411 4283 7175 A pharmaceutical preservative.
SGTC_671 0560-0003 407 µM -1.22521444068954 0.126855247596011 no 2977 0.11024721748273 4220 3238678
SGTC_2533 agelasine 13.65 µM -1.22586694381267 0.126725456071662 no 2978 0.11012437506134 4373 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2584 androsterone 48.74 µM -1.22909761251362 0.126084195701652 no 2979 0.109517605102642 4235 2754130 A steroid.
SGTC_2215 7188065 200 µM -1.22948784541629 0.126006891178457 no 2980 0.109444476109544 4337 940217
SGTC_1004 4084-0029 199 µM -1.23044359013314 0.125817699260263 no 2981 0.109265519298497 4322 716894 YLR208W SEC13
SGTC_1284 0929-0043 16 µM -1.23212304477921 0.125485727417166 no 2982 0.108951562112028 4317 1239883
SGTC_1501 4491-0275 38.4 µM -1.23231694894358 0.125447438469535 no 2983 0.108915355474969 4291 5104718
SGTC_2760 etidronate 98.04 µM -1.23234700186038 0.125441504852654 no 2984 0.108909744636662 4259 3305 A chelator and antioxidant.
SGTC_1930 st074634 34.3 µM -1.23284286409847 0.125343630603641 no 2985 0.108817197835037 4204 684253 YOR116C RPO31
SGTC_3020 9089140 49.47 µM -1.23357752030918 0.125198720758989 no 2986 0.108680186941342 4329 17217859
SGTC_108 0509-0257 621.132 µM -1.23449009162765 0.125018880385644 no 2987 0.108510168313357 4259 536624
SGTC_609 0986-0026 86.3 µM -1.2345360480237 0.125009828536259 no 2988 0.108501611368289 4280 2848610
SGTC_3096 9117468 49.47 µM -1.23560698346675 0.124799020248702 no 2989 0.108302343805401 4227 41316311
SGTC_2861 9024595 19.48 µM -1.23586029673697 0.12474919314712 no 2990 0.108255248675406 4223 16482810
SGTC_1702 st027038 51 µM -1.23981531222284 0.123973038320183 no 2991 0.107521856641068 4345 5521182
SGTC_2014 4013930 200 µM -1.24016382841658 0.123904805889499 no 2992 0.107457402170083 4291 64556
SGTC_3018 9082602 49.47 µM -1.24020424629757 0.123896894586041 no 2993 0.107449929102793 4244 17332089
SGTC_3311 9131146 2.8755 µM -1.24053674232442 0.123831825992709 no 2994 0.107388466438955 4268 4900406 YPR165W RHO1
SGTC_492 tmb-8 126 µM -1.24218940317444 0.123508759588321 no 2995 0.107083344256825 4300 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2003 4023581 200 µM -1.24419629548088 0.123117241404326 no 2996 0.106713663425096 4331 16641307
SGTC_1338 1486-1223 76 µM -1.24593923405764 0.122777923594458 no 2997 0.106393352401676 4331 3444526
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.24661720197875 0.122646113159763 no 2998 0.10626894561279 4280 2333 A French combination drug.
SGTC_1421 4029-0249 71.4 µM -1.24938788976141 0.122108468329685 no 2999 0.105761617817745 4410 2894095
SGTC_3159 9100096 49.47 µM -1.24987246656776 0.122014607740474 no 3000 0.105673069388362 4264 25236875
SGTC_862 0452-0056 10.2 µM -1.25232711350307 0.121539930888292 no 3001 0.105225346502925 4285 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2746 daunorubicin 9.88 µM -1.25305069712116 0.121400253145375 no 3002 0.10509362855922 4310 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3343 9148379 18.9835 µM -1.2537224152399 0.121270688365171 no 3003 0.104971458825933 4352 1955036
SGTC_1997 st073024 93.8 µM -1.25539747810744 0.12094801648378 no 3004 0.104667252194123 4348 686268
SGTC_2914 7968218 45.32 µM -1.25548665122716 0.120930855777532 no 3005 0.10465107546519 4293 2977111
SGTC_1866 st057638 64 µM -1.25602943839207 0.120826437362908 no 3006 0.104552648517822 4316 688802
SGTC_2737 bleomycin 30.5 nM -1.25864141642612 0.120324846803892 no 3007 0.104079940204683 4438 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_697 0508-1955 564 µM -1.25910047210856 0.120236843930265 no 3008 0.103997021973147 4321 6243113
SGTC_27 0485-0001 32.618 µM -1.26130300944277 0.119815239179267 no 3009 0.103599848684636 4322 2054479
SGTC_2333 9017922 200 µM -1.26521426062037 0.119069127458514 no 3010 0.102897265888765 4374 3163164
SGTC_2008 4012253 172 µM -1.26767836649614 0.118600761361097 no 3011 0.102456416727143 4329 603940
SGTC_490 phenamil 164 µM -1.26768080973504 0.118600297608263 no 3012 0.102455980293843 4323 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2759 disulfiram 3.38 µM -1.26993390988286 0.118173180443587 no 3013 0.102054086472405 4256 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_337 1315-0038 354 µM -1.27659795551838 0.116916256409724 no 3014 0.100872112024008 4323 1626437
SGTC_736 0958-0254 92.6 µM -1.28063909988866 0.116158675892201 no 3015 0.100160229844207 4420 6812352
SGTC_1672 st016598 6.51 µM -1.28405741699602 0.115520579999489 no 3016 0.0995609330922901 4323 4665860 YNL267W PIK1
SGTC_1886 st057356 49.9 µM -1.28651988346622 0.115062458280911 no 3017 0.0991308420420117 4339 24207747
SGTC_2099 5377090 177.372 µM -1.28696689656085 0.114979433894441 no 3018 0.0990529132813083 4378 2243829
SGTC_390 dec-rvkr-cmk 16.7 µM -1.28739602431063 0.11489977147042 no 3019 0.0989781446764741 4398 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2843 9000894 45.46 µM -1.28790724441739 0.11480492083701 no 3020 0.0988891266990383 4314 2242070
SGTC_2077 5212015 200 µM -1.28815729583877 0.114758547148674 no 3021 0.0988456069652171 4259 780900
SGTC_1732 st034308 51.822 µM -1.29176602622644 0.114090767937618 no 3022 0.0982190920508339 4226 830119
SGTC_1874 staurosporine 7.6 µM -1.29267446895647 0.113923101699147 no 3023 0.0980618357830366 4361 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1508 1080-0625 72.9 µM -1.2933010135873 0.113807566178375 no 3024 0.0979534851209697 4276 767111
SGTC_891 0929-0073 133 µM -1.29338847983702 0.113791443950325 no 3025 0.0979383662431228 4389 5603632
SGTC_1941 st076221 61.8 µM -1.29434580496944 0.113615091268425 no 3026 0.0977730006933635 4237 2828568
SGTC_661 1304-0007 33.6 µM -1.29481941734082 0.113527917324175 no 3027 0.0976912659955298 4368 3117130
SGTC_1186 1319-0216 26 µM -1.29601499830438 0.113308068730686 no 3028 0.0974851588527373 4429 4565136
SGTC_3069 9117009 49.47 µM -1.29813109645567 0.112919696221773 no 3029 0.0971211451447638 4352 41904981
SGTC_2886 9058944 51.95 µM -1.29942759286186 0.112682217106157 no 3030 0.0968986136914361 4278 4949929
SGTC_1176 0848-0131 83.3 µM -1.30293184551049 0.1120421288487 no 3031 0.0962990153242963 4419 6769040
SGTC_1534 6-azauridine 81.6 µM -1.30812929571808 0.11109755410422 no 3032 0.0954147292145233 4403 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2258 7960471 200 µM -1.30942125607953 0.110863643203711 no 3033 0.0951958475675719 4379 2974708
SGTC_3002 9075603 71.4286 µM -1.30945675755359 0.110857220605875 no 3034 0.0951898381945004 4317 20105405
SGTC_3125 9127534 49.47 µM -1.31102328589517 0.11057408415439 no 3035 0.0949249482898951 4262 1639235
SGTC_3004 9076122 71.4286 µM -1.31587331040499 0.10970077180836 no 3036 0.0941082840861416 4381 44782551
SGTC_1360 1598-0022 39.8 µM -1.32057604877979 0.108858719306585 no 3037 0.0933213816710811 4416 761525
SGTC_44 0929-0055 61.211 µM -1.32368611142644 0.108304403487757 no 3038 0.0928036564603106 4263 1379590
SGTC_2564 betulinic acid 100 µM -1.32517304324939 0.10804010210156 no 3039 0.0925568820056859 4415 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1931 st074438 57.1 µM -1.33100708142228 0.107007590636203 no 3040 0.0915933404308139 4386 2787313
SGTC_3260 9137109 49.47 µM -1.33283920943547 0.106684812872018 no 3041 0.091292287722114 4327 17478346
SGTC_474 dl-dihydrosphingosine 5 µM -1.33502322813793 0.106300959083952 no 3042 0.0909343720973194 4391 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_288 1315-0019 35.1 µM -1.33947513237365 0.105521602379037 no 3043 0.0902080223572586 4422 6811474
SGTC_813 k007-0158 173 µM -1.33971543972422 0.105479651690683 no 3044 0.0901689379953841 4396 6523916
SGTC_3270 9137563 49.47 µM -1.34621985120086 0.104348748385385 no 3045 0.0891158124311334 4385 17015724
SGTC_2000 st075254 36.4 µM -1.34644541107751 0.104309689191707 no 3046 0.0890794570822086 4289 17234175
SGTC_3034 9090421 49.47 µM -1.34658815107361 0.104284977020871 no 3047 0.0890564562013632 4300 17173761
SGTC_1221 2958-7315 257 µM -1.3475222329299 0.10412336681064 no 3048 0.088906048934656 4424 4562705
SGTC_3339 9145883 14.936 µM -1.34772437806005 0.104088416574007 no 3049 0.0888735241277715 4316 2030670
SGTC_2743 auranofin 4.32 µM -1.34872766795999 0.103915076873519 no 3050 0.0887122275810963 4431 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3039 9090270 49.47 µM -1.3528025220493 0.103213210887126 no 3051 0.0880593634198388 4413 17173750
SGTC_1897 st060201 15 µM -1.37081653917503 0.100151653020825 no 3052 0.0852160769075229 4428 611878
SGTC_1837 st055472 66.5 µM -1.37130928344748 0.100068850761654 no 3053 0.0851392814843233 4470 676091
SGTC_1530 rhein 70.4 µM -1.37261512713446 0.0998496545662827 no 3054 0.0849360133436587 4482 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_604 1000-0114 314 µM -1.3726396403909 0.0998455431784206 no 3055 0.0849322010822832 4427 1572745
SGTC_1736 st036774 51 µM -1.37364890770535 0.0996763751930651 no 3056 0.0847753528254393 4458 1272247
SGTC_2369 9071472 200 µM -1.37466786400125 0.0995057957336674 no 3057 0.0846172192620859 4440 17296037
SGTC_1021 4476-0760 85.3 µM -1.37518044828728 0.0994200667202817 no 3058 0.0845377541235095 4442 746768
SGTC_330 1488-0319 80.1 µM -1.37861824356158 0.0988464951788864 no 3059 0.0840062443214847 4459 6846614
SGTC_8 0354-0001 70 µM -1.37876915865066 0.0988213716700613 no 3060 0.0839829693019701 4420 4993152
SGTC_3261 9137475 49.47 µM -1.37939518135441 0.0987172047672652 no 3061 0.083886472071887 4429 17027690
SGTC_576 1073-0113 22.7 µM -1.38119947244415 0.0984174297866589 no 3062 0.0836088184757064 4522 5439563
SGTC_1770 st043884 66.3 µM -1.38197001247526 0.0982896112947498 no 3063 0.0834904544431627 4428 670149
SGTC_1616 st002734 56.1 µM -1.38433485944132 0.0978980857082845 no 3064 0.0831279723988794 4380 4026101
SGTC_602 3130-1533 38.1 µM -1.38534271315476 0.09773157263101 no 3065 0.0829738494603363 4475 720941
SGTC_2288 7946289 167.31 µM -1.38778960616403 0.0973281721085561 no 3066 0.0826005603632493 4448 1246052
SGTC_1992 st073643 23.3 µM -1.38915448818567 0.097103685887404 no 3067 0.0823928888644034 4422 3161292
SGTC_2064 5220758 200 µM -1.38985452275392 0.0969886966546439 no 3068 0.0822865288376949 4463 788518
SGTC_965 1291-5240 308 µM -1.3907805553374 0.096836738103887 no 3069 0.0821459906160701 4422 2834598
SGTC_1320 1313-0481 95.3 µM -1.39177496489393 0.0966737538808385 no 3070 0.0819952766534735 4397 6813365 YLR208W SEC13
SGTC_1249 0481-0015 10.2 µM -1.39242846278852 0.0965667550166151 no 3071 0.0818963452017028 4363 4227577
SGTC_2473 5854593 8.94 µM -1.39284582927082 0.0964984640863713 no 3072 0.0818332081963291 4349 2872951
SGTC_669 0108-0021 26.2 µM -1.39526179448388 0.0961038526664277 no 3073 0.0814684543102605 4449 17201
SGTC_2730 imipramine 71.33 µM -1.39613430725464 0.095961632882363 no 3074 0.0813370272184177 4390 3696 A tricyclic antidepressant.
SGTC_859 0439-0102 54.6 µM -1.396511135512 0.0959002576698636 no 3075 0.0812803148437975 4460 610143
SGTC_1519 esterone 74 µM -1.39851236019082 0.0955747956045212 no 3076 0.0809796318013885 4407 698 A steroid.
SGTC_2644 guaiazulene 100 µM -1.40141252479642 0.0951045812179093 no 3077 0.0805453745264268 4463 3515 A coloring agent.
SGTC_1915 st067105 30.6 µM -1.40738620025907 0.0941414203413562 no 3078 0.0796564504752418 4378 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1434 4073-0095 163 µM -1.41039102965057 0.0936596679717321 no 3079 0.0792121263343394 4441 24133745
SGTC_3205 9113483 49.47 µM -1.41230958092323 0.0933530278631901 no 3080 0.0789294132883303 4443 17018033
SGTC_1730 st033808 45.1 µM -1.41526993863728 0.0928813329611984 no 3081 0.078494682710263 4366 1045166
SGTC_1984 st072354 53.1 µM -1.41564239974515 0.0928221111028404 no 3082 0.0784401153441889 4314 5762938
SGTC_2212 7123476 200 µM -1.41643666018314 0.092695915800612 no 3083 0.0783238483834084 4463 1085715
SGTC_790 1575-0012 79.1 µM -1.41733234534172 0.0925537580114087 no 3084 0.0781928913056126 4484 378741 YLR208W SEC13
SGTC_289 k017-0060 526 µM -1.42046198396248 0.0920583067869501 no 3085 0.0777366142885448 4441 5512909
SGTC_1846 st056244 14.8 µM -1.42432257875353 0.0914498470074294 no 3086 0.0771765571886051 4476 5393182
SGTC_3058 9093861 49.47 µM -1.42509909171791 0.091327823421824 no 3087 0.0770642795916495 4451 17217477
SGTC_21 0849-0113 22.993 µM -1.42680306880501 0.0910604784688753 no 3088 0.0768183331953609 4413 1560156
SGTC_3011 9081274 71.4286 µM -1.42687358638036 0.091049427157132 no 3089 0.0768081677970082 4453 6625322
SGTC_3060 1327-0027 12.5 µM -1.4301618915324 0.0905351975620386 no 3090 0.0763352800542203 4367 16000455 YPR107C YTH1
SGTC_1468 k284-1086 134 µM -1.43328979061083 0.0900480563404945 no 3091 0.0758875191965781 4453 15996457
SGTC_2073 5212005 126 µM -1.43481406407221 0.0898113718845514 no 3092 0.0756700445533939 4347 691789
SGTC_2020 4017018 200 µM -1.4352554528879 0.0897429208144006 no 3093 0.0756071584472301 4490 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1659 st012954 42.1 µM -1.43642545276974 0.0895616635958429 no 3094 0.0754406574079778 4441 24207262
SGTC_466 geldanamycin 89.2 µM -1.43650834593289 0.0895488320624326 no 3095 0.075428871607255 4474 5288382 HSP90 inhibitor.
SGTC_2619 obliquin 87.91 µM -1.43662012243969 0.0895315316665172 no 3096 0.0754129813770065 4429 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2054 5233173 129 µM -1.43830689030908 0.0892707610447282 no 3097 0.0751734988637721 4465 6889
SGTC_945 3381-0768 11.3 µM -1.43844993126761 0.0892486732451453 no 3098 0.0751532170166824 4468 1126236 YIL048W NEO1
SGTC_1149 3909-7961 23.3 µM -1.44316288640303 0.0885231902656414 no 3099 0.0744872958359818 4510 735261
SGTC_2995 9067767 71.4286 µM -1.44471060399048 0.0882859051208255 no 3100 0.0742695950641825 4463 11673567
SGTC_2834 9001755 58.44 µM -1.44734431345803 0.0878832135251741 no 3101 0.0739002569024681 4335 2989575
SGTC_1471 k673-0312 37 µM -1.44761776576422 0.0878414815627679 no 3102 0.0738619898983487 4440 24099884
SGTC_2444 5485484 36.41 µM -1.44816926158269 0.087757361934395 no 3103 0.0737848594653523 4517 6790631
SGTC_1084 voriconazole 435 nM -1.44869515106917 0.0876772040242392 no 3104 0.0737113676062047 4479 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1415 3966-0071 78.1 µM -1.45167869730659 0.0872234752933852 no 3105 0.0732954826381511 4376 2893185
SGTC_2983 9022671 12.99 µM -1.45321952293277 0.0869898387809733 no 3106 0.073081406649219 4444 6405161
SGTC_1296 1068-0102 11.9 µM -1.45338763040381 0.086964376832575 no 3107 0.0730580794667872 4478 767053
SGTC_141 0443-0274 32.331 µM -1.45571345916168 0.086612672539258 no 3108 0.0727359238263654 4406 1627241
SGTC_3336 9143619 71.43 µM -1.45585917304619 0.0865906735994674 no 3109 0.0727157769436482 4475 45595730
SGTC_2078 5212016 200 µM -1.45722823509186 0.0863841853996555 no 3110 0.0725266945397295 4373 1899708
SGTC_2667 digitoxin 100 µM -1.4587761266613 0.0861511690425412 no 3111 0.0723133677091473 4432 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_269 exalamide 29 µM -1.46218969621777 0.0856389597385645 no 3112 0.0718446172001631 4424 3316 A derivative of salicylamide.
SGTC_1181 1222-0449 220 µM -1.46428457410761 0.0853257523500986 no 3113 0.0715581051019825 4522 658318
SGTC_128 0906-2981 13.371 µM -1.46803864215087 0.0847666257020754 no 3114 0.0710468633604174 4468 6740226
SGTC_731 3966-0296 387 µM -1.46827064772239 0.084732161410682 no 3115 0.0710153603274697 4474 660956
SGTC_1242 0402-0103 60.1 µM -1.47117894019724 0.0843010273290514 no 3116 0.0706213654924251 4398 432868
SGTC_1872 amphotericin b 148 nM -1.47350529027734 0.0839573489225958 no 3117 0.0703074192065811 4487 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_389 tpck 16.7 µM -1.47379693130292 0.0839143382759031 no 3118 0.0702681374047344 4518 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_464 bw-b 70c 158 µM -1.47512592199293 0.083718550820885 no 3119 0.0700893462560894 4478 5353454
SGTC_1813 st051246 8.6015 µM -1.47964916960777 0.0830547554850969 no 3120 0.0694834486478719 4435 5291959
SGTC_537 1334-0398 209 µM -1.48099629933443 0.0828578286162637 no 3121 0.0693037798152822 4503 5846986
SGTC_2201 6605497 169.863 µM -1.48453888956218 0.0823416404867117 no 3122 0.0688330069844045 4443 670741
SGTC_364 0083-0097 67.7 µM -1.48785252124302 0.0818610090586789 no 3123 0.0683948955765405 4510 5207356
SGTC_1189 1431-2119 7.28 µM -1.49231713088483 0.0812167795428618 no 3124 0.0678080139452961 4474 3107275
SGTC_1742 st038235 28.8875 µM -1.4959466261893 0.0806958793469572 no 3125 0.067333782259423 4521 564103 YBR002C RER2
SGTC_1796 st049173 110.4 µM -1.5107917701823 0.0785915644826289 no 3126 0.0654207560855954 4484 94134
SGTC_127 0180-0333 59.125 µM -1.5143887969417 0.0780879979044943 no 3127 0.0649636294926352 4402 771601
SGTC_967 1306-0166 352 µM -1.51445580472376 0.078078640412879 no 3128 0.0649551374227172 4498 4437607
SGTC_3045 9092950 49.47 µM -1.51510958318223 0.0779873863020971 no 3129 0.0648723275963364 4482 44120432
SGTC_3086 9117350 49.47 µM -1.51605958860512 0.0778549292203844 no 3130 0.0647521427564637 4479 2679265
SGTC_938 3126-1755 342 µM -1.51775654577033 0.077618751341284 no 3131 0.0645378916752042 4487 1777771
SGTC_822 1487-0950 154 µM -1.51838570624485 0.0775313248595329 no 3132 0.0644585964538017 4507 1958375
SGTC_2669 eugenol 100 µM -1.51982491365989 0.0773316175766585 no 3133 0.0642774929081516 4529 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1089 terbinafine 2.25 µM -1.52224921119482 0.0769961010498275 no 3134 0.06397332435439 4512 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2790 5423970 71.43 µM -1.52486181547063 0.0766357632517479 no 3135 0.0636467838650964 4528 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1081 sertraline 6 µM -1.52591352742462 0.076491070752144 no 3136 0.0635157006565047 4497 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.5273360192459 0.076295697831038 no 3137 0.0633387385899877 4477 16623 A steroid.
SGTC_307 1501-1223 22.3 µM -1.52829533868957 0.0761641541336486 no 3138 0.0632196133634412 4534 2830329
SGTC_2628 lathosterol 100 µM -1.53317659959487 0.075497498955912 no 3139 0.0626161741305368 4532 6710616
SGTC_2347 9049783 174.81 µM -1.53716446443227 0.0749561667213797 no 3140 0.0621265199818879 4484 6467988 YPL169C MEX67
SGTC_2448 5185112 27.17 µM -1.54007255557026 0.0745632786077898 no 3141 0.0617713343116333 4516 5718189
SGTC_442 cape 100 µM -1.54160739331471 0.0743565541131646 no 3142 0.0615845139282206 4542 5281787
SGTC_1357 1503-1303 39.5 µM -1.54683908625446 0.0736551943559184 no 3143 0.0609510262550606 4497 292895
SGTC_844 0330-0132 15.3 µM -1.54815978048804 0.0734789443905847 no 3144 0.0607919160410648 4575 2828079
SGTC_2744 captopril 92.04 µM -1.54881094408972 0.0733921637691674 no 3145 0.0607135869590555 4585 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2545 solidagenone 89.61 µM -1.55642857576331 0.0723827756610183 no 3146 0.0598031072491248 4464 6708572 An anti ulcer agent
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.55822194126865 0.0721466965595636 no 3147 0.0595903227352889 4551 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_48 0382-0018 55 µM -1.55945027428454 0.0719853393530375 no 3148 0.05944492255446 4547 762596
SGTC_2263 7948595 193.29 µM -1.55982864745577 0.0719356909962416 no 3149 0.0594001898541151 4546 2971371
SGTC_1319 1306-0155 43.7 µM -1.56032072945667 0.071871161582967 no 3150 0.0593420535493499 4550 3122360
SGTC_14 0354-0009 295 µM -1.56152253989482 0.0717137481928751 no 3151 0.0592002549444232 4616 1713507
SGTC_1298 1079-1278 263 µM -1.56360857160682 0.0714411474152063 no 3152 0.0589547603304662 4506 2840950
SGTC_1333 1482-0047 286 µM -1.56909170734306 0.0707284086048923 no 3153 0.0583132858907242 4567 3811116
SGTC_1769 st044406 64.4 µM -1.57237243999214 0.0703045747467628 no 3154 0.0579321009956894 4514 670903
SGTC_1311 1190-0148 100 µM -1.57666598720957 0.0697528504853587 no 3155 0.05743620027173 4568 1961333
SGTC_2739 tacrine 100.86 µM -1.57889138338405 0.0694681997205201 no 3156 0.0571804863774743 4597 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3257 9139206 32.98 µM -1.57931874664564 0.0694136381564628 no 3157 0.0571314820085293 4524 4910041
SGTC_577 r071-0003 38.6 µM -1.58068451514869 0.0692394914538641 no 3158 0.05697509534368 4505 4568517 YMR134W ERG29
SGTC_1948 st076329 66.6 µM -1.58263818248986 0.0689909681907035 no 3159 0.0567519777479688 4464 24208413
SGTC_2107 5363541 170.161 µM -1.58456568516866 0.068746447648695 no 3160 0.0565325233069425 4475 244052
SGTC_196 k015-0023 18.111 µM -1.5896242100958 0.0681079077774499 no 3161 0.0559597682770999 4498 5211998
SGTC_2504 purpurogallin 52.29 µM -1.59084535443201 0.067954450358345 no 3162 0.0558221915318018 4481 5281571 An antioxidant.
SGTC_2144 5628481 200 µM -1.59161865842455 0.0678574098017396 no 3163 0.0557352075407851 4532 2818399
SGTC_547 1120-0019 610 nM -1.59169172240801 0.0678482466674576 no 3164 0.0557269945767351 4523 3676939
SGTC_1670 st016595 4.04 µM -1.59959569229511 0.0668626221674115 no 3165 0.0548441523548719 4573 597879
SGTC_435 c-PAF 6.7 µM -1.60451155995592 0.0662552238650515 no 3166 0.0543006692154132 4464 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.60999441251018 0.065582820355754 no 3167 0.0536995380520064 4554 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2933 9026794 32.47 µM -1.61591250424379 0.0648629910904429 no 3168 0.0530566158605811 4495 17586027
SGTC_415 dibenzyl ketone 100 µM -1.62412841713712 0.0638738607489903 no 3169 0.0521742021209119 4537 7593
SGTC_1192 1488-0095 21.4 µM -1.62713272486864 0.0635151094812923 no 3170 0.0518544560488114 4591 915875
SGTC_276 colchicine 750 µM -1.62857637802337 0.0633432782892732 no 3171 0.0517013641353211 4578 2833 A microtubule depolymerizer.
SGTC_2791 5663188 71.43 µM -1.62997463597981 0.0631771954772804 no 3172 0.0515534288840406 4563 54690634
SGTC_199 4063-0024 41.6 µM -1.63003083307711 0.0631705275720596 no 3173 0.0515474902917575 4602 306215
SGTC_574 1315-0397 40 µM -1.63063053290543 0.0630994060340253 no 3174 0.0514841512655096 4545 6794277
SGTC_559 1550-0661 158 µM -1.63467031135688 0.0626219314019618 no 3175 0.051059089695257 4603 5830875
SGTC_2688 kanamycin b 96.69 µM -1.63828278014642 0.062197351350036 no 3176 0.0506813590625733 4527 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2191 5911152 200 µM -1.63866804660485 0.0621522031105114 no 3177 0.0506412061157996 4590 2875902
SGTC_18 0111-0177 500 nM -1.63956293251319 0.0620474327339149 no 3178 0.0505480377759822 4637 721752
SGTC_2532 xanthone 78.9 µM -1.64325795286332 0.0616162901696731 no 3179 0.0501647869585006 4575 7020 An insecticide.
SGTC_1545 lovastatin 49.4 µM -1.64378502981075 0.0615549808586351 no 3180 0.0501103073438591 4598 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2252 omeprazole 400 µM -1.65246520229218 0.0605521459846561 no 3181 0.0492198765938084 4601 4594 A proton pump inhibitor.
SGTC_2570 licareol 100 µM -1.65437308592412 0.060333447914508 no 3182 0.0490258657298459 4535 443158
SGTC_2576 guaiol 23.12 µM -1.65800244693175 0.0599191262905709 no 3183 0.0486584862402596 4474 227829
SGTC_1675 st018485 24.5 µM -1.66356912740633 0.0592879778297878 no 3184 0.0480992828734344 4561 3323024
SGTC_3271 9137798 49.47 µM -1.66401142405362 0.0592380547683348 no 3185 0.0480550732166242 4570 6498326
SGTC_3202 9113761 49.47 µM -1.66631705342263 0.0589783465811431 no 3186 0.0478251409318025 4503 4798415
SGTC_3282 9108498 15.4605 µM -1.66700651270524 0.0589008590062722 no 3187 0.0477565549343975 4558 16459645
SGTC_534 k292-0788 63.4 µM -1.67229036011252 0.0583096622773578 no 3188 0.0472335398096773 4625 4146317
SGTC_3219 9131112 49.47 µM -1.67308846698427 0.0582207706567093 no 3189 0.0471549408007417 4447 17612988 YMR079W SEC14
SGTC_1343 1487-0095 224 µM -1.67495597104766 0.0580131876197329 no 3190 0.0469714353031498 4571 4560101 YGL055W OLE1
SGTC_1798 st045719 60.953 µM -1.67577927835151 0.0579218575620713 no 3191 0.0468907172138887 4560 3980186
SGTC_3177 9107506 49.47 µM -1.67669373938909 0.0578205482750601 no 3192 0.0468011927457642 4559 8897194
SGTC_403 arphamenine a 50 µM -1.67806930084142 0.0576684180578358 no 3193 0.0466667854805218 4584 5487158 An arginine aminopeptidase inhibitor.
SGTC_1781 st038725 66.3 µM -1.67864512263436 0.0576048285820621 no 3194 0.0466106134894945 4574 4270275 YIL048W NEO1
SGTC_190 3970-0790 3.722 µM -1.68292657905197 0.0571337442658109 no 3195 0.0461946527674181 4542 2832352
SGTC_279 1273-0055 2.93 µM -1.68384748643613 0.0570328151255246 no 3196 0.0461055736395686 4628 2847562
SGTC_2710 st078562 53.7235 µM -1.68396653842831 0.0570197775782207 no 3197 0.0460940678498623 4554 17250908
SGTC_2430 5571206 200 µM -1.6925266274922 0.056088484842295 no 3198 0.045272803759475 4565 1731771
SGTC_1496 4469-0713 57.4 µM -1.69421226844128 0.0559065174855771 no 3199 0.0451124771891047 4590 746691
SGTC_2738 aclarubicin 5.55 µM -1.69741376952289 0.0555621933918897 no 3200 0.0448092305584412 4634 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2491 paeonol 100 µM -1.70444204294539 0.0548121687344661 no 3201 0.0441492675105266 4578 11092 Increases levels of cortical cytochrome oxidase.
SGTC_418 lividomycin a 100 µM -1.70876303297273 0.054355039938913 no 3202 0.0437474264368568 4609 72394 An antibiotic.
SGTC_2184 6075246 200 µM -1.71605912246783 0.0535900189582247 no 3203 0.0430756109690995 4580 2267320
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.71872225224979 0.0533129146233308 no 3204 0.0428324790978383 4660 4213774
SGTC_2986 9022445 71.43 µM -1.72002363564121 0.053177916610091 no 3205 0.0427140726629674 4569 6459286
SGTC_1007 4101-0031 70 µM -1.72045135092341 0.0531336071111772 no 3206 0.0426752147898393 4593 1146276
SGTC_1416 3966-0321 25.3 µM -1.72723400298917 0.0524348584284321 no 3207 0.0420628232044842 4658 582530 YLR208W SEC13
SGTC_2685 mycophenolic acid 18.85 µM -1.73278533213485 0.0518684061940042 no 3208 0.0415669154330892 4617 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2004 4023728 41.89 µM -1.7347228775425 0.0516718496811273 no 3209 0.0413949510587032 4553 360084 YDR527W RBA50
SGTC_38 0929-0051 58.268 µM -1.73511213286669 0.05163243275134 no 3210 0.0413604728465329 4554 1379719
SGTC_1739 st037196 92.5 µM -1.74132323222901 0.0510067102619163 no 3211 0.0408134680614413 4598 612214
SGTC_3289 9119912 71.43 µM -1.7420431187505 0.0509345789869872 no 3212 0.0407504497741102 4594 17014829
SGTC_2488 5268135 45.7 µM -1.74333362592858 0.0508054758735088 no 3213 0.0406376774666157 4611 1270356 YLR208W SEC13
SGTC_1331 1472-0049 76.2 µM -1.74895617566234 0.0502460304679595 no 3214 0.0401492975172014 4593 24051409
SGTC_1841 st054148 70 µM -1.74932357565838 0.050209645644684 no 3215 0.040117551493236 4624 675442
SGTC_341 1486-1430 230 µM -1.75094988746971 0.0500488388411052 no 3216 0.0399772712103053 4568 2054753 YPL210C SRP72
SGTC_2439 5492030 7.2 µM -1.75115256456809 0.0500288273015511 no 3217 0.0399598169225252 4608 5722370
SGTC_1657 st012939 43.4 µM -1.75357692461159 0.049789949805346 no 3218 0.0397515139239062 4603 24207257
SGTC_1456 k015-0012 13 µM -1.75558027975513 0.0495932421969029 no 3219 0.0395800509402583 4604 2989616
SGTC_2955 9076254 12.21 µM -1.7673094231234 0.0484539827045353 no 3220 0.038588211294092 4558 16459619
SGTC_770 0389-1121 67.2 µM -1.76819578043413 0.0483687478528749 no 3221 0.0385140896887133 4655 6753108
SGTC_1432 4049-0298 68.4 µM -1.76820553043008 0.0483678109304755 no 3222 0.0385132749912475 4639 741646
SGTC_1323 1348-1351 11.2 µM -1.77567901820232 0.0476539079102959 no 3223 0.0378929188045162 4619 6989654
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.77666160689118 0.0475606773352058 no 3224 0.0378119663766277 4521 88881 An O-methylated flavonoid and antioxidant.
SGTC_1970 st070122 35.8 µM -1.78023268602447 0.0472230738640853 no 3225 0.0375189441112989 4624 102928
SGTC_2807 7945238 51.95 µM -1.78649535375991 0.0466356527546535 no 3226 0.0370095444256703 4597 17148797
SGTC_556 4058-0063 51.5 µM -1.78741165281271 0.0465502002278901 no 3227 0.0369354898063166 4634 6615692
SGTC_195 4234-0266 16.654 µM -1.79325970376444 0.0460077770367223 no 3228 0.0364657037447558 4644 2303354
SGTC_2897 9048598 12.99 µM -1.80145820024853 0.0452559051220115 no 3229 0.0358153449690437 4607 6467404
SGTC_89 0302-0250 142.109 µM -1.80546060461712 0.0448924582653383 no 3230 0.0355013174526807 4679 4203518 YLR208W SEC13
SGTC_104 0074-0074 590.992 µM -1.81514577376021 0.0440226943912908 no 3231 0.0347507552053751 4540 3943124
SGTC_1204 4049-0315 18.3 µM -1.81651913463977 0.0439004689854176 no 3232 0.0346453877192344 4626 588402
SGTC_950 1165-0508 94.1 µM -1.81683588916055 0.0438723175690721 no 3233 0.0346211228407072 4616 6148369
SGTC_1907 st060210 83.7 µM -1.81956147591933 0.0436306835305999 no 3234 0.0344129064322353 4623 688793
SGTC_297 0986-0032 24 µM -1.82448140008308 0.0431972325221998 no 3235 0.0340396628874489 4616 2847425
SGTC_150 3970-0969 77.2 µM -1.82840105645229 0.0428544010304138 no 3236 0.0337446914734368 4639 6615640
SGTC_1737 st035557 69.7 µM -1.82910204246504 0.0427933219281287 no 3237 0.0336921615312953 4493 5716916
SGTC_1469 k284-2957 126 µM -1.83033170681501 0.0426863474195125 no 3238 0.0336001764670261 4642 23884841
SGTC_3237 9133362 49.47 µM -1.83333609061799 0.0424258906080594 no 3239 0.0333763026883041 4631 43845137
SGTC_502 l-744,832 89.3 µM -1.83334711996312 0.0424249368226892 no 3240 0.0333754830972634 4646 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2384 9036245 200 µM -1.83887871773417 0.0419487616972662 no 3241 0.0329665133665256 4624 6462766
SGTC_2385 9074692 200 µM -1.83940453059384 0.041903724373897 no 3242 0.0329278541229811 4639 17046906
SGTC_958 1222-0007 33 µM -1.84611931577464 0.0413320195634968 no 3243 0.0324374413980256 4663 7312461
SGTC_803 4488-1585 147 µM -1.85098631784079 0.040921602082812 no 3244 0.0320857607448275 4650 747204
SGTC_1615 st002656 86.5 µM -1.85242422533272 0.0408009829202332 no 3245 0.031982464639304 4640 1584458
SGTC_1942 st076330 65.2 µM -1.85307075470725 0.0407468427641983 no 3246 0.0319361089740757 4657 24208414
SGTC_616 4092-0450 108 µM -1.86997203935371 0.039352095581041 no 3247 0.0307438503804858 4657 787165
SGTC_7 0192-1582 4.227 µM -1.88206897175896 0.0383778675129571 no 3248 0.0299133257889645 4681 252616
SGTC_3183 9108214 49.47 µM -1.88591894731024 0.0380719659096737 no 3249 0.0296529389158817 4675 4974831
SGTC_2952 9073731 13.78 µM -1.88999305649516 0.0377504246264563 no 3250 0.0293794443631974 4625 16457353
SGTC_1368 1852-0141 284 µM -1.89955882326637 0.0370041716146893 no 3251 0.0287455201219863 4616 2838987
SGTC_1169 aniline yellow 25.8 µM -1.90029469996557 0.036947266806669 no 3252 0.028697228250593 4614 6051 A DNA damaging agent.
SGTC_2366 9070441 60.58 µM -1.90134340006229 0.0368662952343355 no 3253 0.0286285239546524 4624 6837235
SGTC_1916 st067606 49.2 µM -1.9025784150464 0.0367711241464438 no 3254 0.0285477889399789 4556 19590279
SGTC_584 0986-0246 15.4 µM -1.92409229796168 0.0351452441944704 no 3255 0.0271715076689597 4711 53315 YDR232W HEM1
SGTC_2329 6138490 200 µM -1.9292700058968 0.0347628814993209 no 3256 0.0268486756510851 4652 720019
SGTC_1913 st060213 96.1 µM -1.94007900807446 0.0339756646354185 no 3257 0.0261850443693792 4648 688959
SGTC_2740 felodipine 17.08 µM -1.94008548207486 0.0339751975660698 no 3258 0.0261846510384151 4712 3333 L-type calcium channel blocker
SGTC_3001 9076041 71.4286 µM -1.94038879151229 0.0339533211038537 no 3259 0.0261662288665123 4665 16004211
SGTC_2045 5106652 78.05 µM -1.94635225648509 0.0335255488931345 no 3260 0.0258062202208542 4666 673349
SGTC_2588 indole-3-carbinol 100 µM -1.94681432389708 0.0334925898265761 no 3261 0.0257784995317738 4642 3712 Induces cell cycle arrest.
SGTC_1116 jasmonic acid 1.58368 µM -1.95106352398259 0.0331907450729775 no 3262 0.0255247448104296 4707 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_66 0109-0187 42.4 µM -1.97219121524127 0.0317230176371563 no 3263 0.0242938910678818 4511 759417
SGTC_3009 9080819 71.4286 µM -1.98301138162526 0.0309923642649879 no 3264 0.0236830791112631 4693 17027216
SGTC_2161 5662504 8.5105 µM -1.98605811198096 0.0307891587627196 no 3265 0.0235134358442878 4692 2859334
SGTC_1053 3366-3204 134 µM -1.99773071418003 0.0300208218619632 no 3266 0.0228729312335038 4681 3632071 YPR165W RHO1
SGTC_84 0443-0269 128.823 µM -2.00269427140341 0.0296989533399781 no 3267 0.022605057029059 4665 6150058
SGTC_1466 k213-0079 57.5 µM -2.00364806511062 0.0296374324703434 no 3268 0.0225538866093734 4690 3657981
SGTC_2770 toltrazuril 17.5 µM -2.02064170667507 0.0285589336842371 no 3269 0.0216584341275993 4636 68591 Kills coccidiodes.
SGTC_1812 st052057 4.327 µM -2.02255720099158 0.0284394406865022 no 3270 0.0215594102746617 4713 3645418
SGTC_3047 9092122 49.47 µM -2.02716150094622 0.0281539146252184 no 3271 0.0213229494783396 4661 17173831
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.04042036382243 0.027344997042513 no 3272 0.0206542376848439 4637 676296 Flavone; oxidizing agent.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.0405973631155 0.0273343309009492 no 3273 0.0206454322511284 4711 688664
SGTC_3073 9114972 49.47 µM -2.04236664490964 0.0272279029146891 no 3274 0.0205575879035524 4693 41905075
SGTC_2845 9003024 42.97 µM -2.04735544644549 0.0269296705719851 no 3275 0.0203115987596115 4673 2990173
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.05374306906307 0.0265518018681505 no 3276 0.0200002828395665 4687 229346 A bile salt which induces apoptosis.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.05746713015168 0.0263335512074036 no 3277 0.0198206567859164 4694 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1349 flufenamic acid 69 µM -2.06174560782031 0.0260846617157661 no 3278 0.0196159809821384 4644 3371 A non-steroidal anti-inflammatory.
SGTC_354 2783-3500 4.88 µM -2.06644684137832 0.0258134511270316 no 3279 0.019393153450928 4691 6740761
SGTC_1693 xanthone 101.9 µM -2.07655974382528 0.0252380371163851 no 3280 0.0189211058154966 4735 7020 An insecticide.
SGTC_2403 6032726 181.2 µM -2.07708502700369 0.0252084450288886 no 3281 0.0188968561360345 4675 2881040
SGTC_2063 5246145 200 µM -2.08291119348176 0.0248821703797095 no 3282 0.0186296595634934 4682 711240
SGTC_913 3487-1245 167 µM -2.08685311599307 0.0246634309989202 no 3283 0.0184507070175244 4654 4016153
SGTC_277 nystatin 15.5 µM -2.09164987887376 0.0243994344279124 no 3284 0.0182349235688043 4722 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1891 st059073 26.2 µM -2.09328693630402 0.0243098813926794 no 3285 0.0181617740546952 4728 688754
SGTC_791 1348-1292 225 µM -2.0960974793897 0.0241567780893718 no 3286 0.0180367722878984 4695 5437054
SGTC_2434 5670830 169.91 µM -2.10235204426094 0.0238189680474557 no 3287 0.0177612243615192 4706 1549830
SGTC_2902 5787006 60.46 µM -2.10865443701263 0.0234826005447574 no 3288 0.0174872101854268 4698 591003
SGTC_1838 st055369 84.5 µM -2.1143396877527 0.0231826079385315 no 3289 0.0172431324620597 4697 676036
SGTC_3231 9132313 49.47 µM -2.12397246552157 0.0226816826562846 no 3290 0.0168362230290826 4708 4905967
SGTC_1520 flindersine 88 µM -2.12839774716783 0.0224546348206491 no 3291 0.0166520598899351 4695 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3119 9125183 49.47 µM -2.14039132872665 0.0218488973285795 no 3292 0.0161615773551924 4686 22695334
SGTC_3305 9127027 53.8275 µM -2.14844269630594 0.0214500510004564 no 3293 0.0158393020174713 4681 41905295
SGTC_2262 9014885 67.46 µM -2.1487744242957 0.0214337508461082 no 3294 0.0158261428661333 4746 6457424
SGTC_2717 st081029 62.2815 µM -2.15520376598845 0.0211198938807207 no 3295 0.0155729461756772 4704 5292846
SGTC_2525 harmine 47.85 µM -2.16098465260841 0.0208410204042828 no 3296 0.0153482624845916 4733 5280953 A monoamine oxidase inhibitor
SGTC_2691 st077356 60.2 µM -2.16772098342266 0.0205199947198177 no 3297 0.0150899609764556 4683 2839272
SGTC_2524 avocatin b 10.57 µM -2.18066875408247 0.0199147144981939 no 3298 0.0146039628640564 4739 6710748
SGTC_232 clozapine 119 µM -2.19738078508183 0.0191559180154591 no 3299 0.0139966312070013 4765 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3117 9124945 49.47 µM -2.22043535497898 0.0181495874204837 no 3300 0.0131946146657302 4674 17592065
SGTC_1132 3456-3614 2.5 µM -2.23804357481222 0.017411662696519 no 3301 0.0126091068343919 4693 3125502
SGTC_368 fentichlor 4.58 µM -2.23932054948228 0.0173591581913956 no 3302 0.0125675333706872 4712 7329 A pesticide.
SGTC_2474 5321570 43.32 µM -2.25164057759612 0.0168595124946352 no 3303 0.012172497303984 4732 2841384
SGTC_800 3448-7362 155 µM -2.26958054784767 0.0161539676478637 no 3304 0.0116165224843465 4771 15991913
SGTC_2469 5655019 90.81 µM -2.2745884464057 0.0159615918406915 no 3305 0.0114653149199089 4761 2788239
SGTC_2946 9065502 71.43 µM -2.27584173481938 0.0159137558209722 no 3306 0.0114277419091837 4689 16489101
SGTC_2520 obtusaquinone 4.71 µM -2.29890217316689 0.0150552676169643 no 3307 0.0107552474921002 4750 5967872
SGTC_3162 9099653 49.47 µM -2.29892905778336 0.0150542904630868 no 3308 0.010754484029234 4738 25237511
SGTC_3317 9138495 8.753 µM -2.299230769685 0.0150433281170194 no 3309 0.010745919322834 4696 17020139
SGTC_718 1130-0073 349 µM -2.30462586245552 0.014848458879842 no 3310 0.0105937681221967 4748 6740020
SGTC_2707 st078556 66.6 µM -2.30590181901463 0.014802690374405 no 3311 0.010558059488832 4699 17250899
SGTC_192 3455-0609 60.9 µM -2.31515935431723 0.0144742422446777 no 3312 0.0103021063722135 4765 3769639
SGTC_2204 7233102 200 µM -2.32776051317175 0.0140372598285657 no 3313 0.00996241194995807 4768 2172480
SGTC_2310 7668677 200 µM -2.36678507603061 0.0127553531965605 no 3314 0.00897167471721494 4692 2197143
SGTC_2363 9053361 176 µM -2.37499135158124 0.0124990666570354 no 3315 0.0087746806872028 4729 6469797 YMR079W SEC14
SGTC_2970 9090938 41.86 µM -2.37558602109766 0.0124806692792007 no 3316 0.00876055395109022 4738 17217104
SGTC_1876 myriocin 605 nM -2.38167958547419 0.0122934989562487 no 3317 0.00861694268046572 4711 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.38832688591299 0.0120920982158971 no 3318 0.0084626400227808 4728 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2625 euphol 100 µM -2.38986452444299 0.0120459201121656 no 3319 0.0084272943532291 4723 6708538 A triterpene alcohol.
SGTC_2939 9044578 71.43 µM -2.39313112002984 0.0119483254702911 no 3320 0.0083526349660892 4710 2653634
SGTC_922 1866-0035 480 µM -2.4078230994699 0.0115178114898026 no 3321 0.00802397748158302 4701 3156169
SGTC_3354 9151612 71.43 µM -2.41198428782694 0.0113983526698249 no 3322 0.00793298262314137 4730 27261949
SGTC_592 k241-0073 46.5 µM -2.41999352092949 0.0111714519717375 no 3323 0.0077603918196342 4777 4230158
SGTC_291 SEC14.278 35.5 µM -2.42089675843744 0.0111461114465346 no 3324 0.00774113683759157 4759 1068044
SGTC_959 1222-0044 107 µM -2.48631188164082 0.00943884626456087 no 3325 0.00645373954961649 4758 6083612
SGTC_2472 5377652 49.4 µM -2.5055059698723 0.00898340652801896 no 3326 0.00611381670520766 4774 1610903
SGTC_244 nsc-207895 1.295 µM -2.50610383638292 0.0089695348752163 no 3327 0.0061034882787739 4720 42640
SGTC_2327 6189656 200 µM -2.52187775966982 0.00861026572046018 no 3328 0.00583651323480494 4762 5349088
SGTC_1178 0988-0033 191 µM -2.52699081249944 0.00849655060240346 no 3329 0.0057522256134006 4773 5392207
SGTC_1505 k297-0037 20.6 µM -2.53767843421269 0.00826310470442075 no 3330 0.00557952329544091 4761 4089396
SGTC_2324 6149169 200 µM -2.58478300739326 0.00730004725272798 no 3331 0.00487201500872114 4769 2888231
SGTC_154 3389-1638 511.116 µM -2.60933295369456 0.00683847853267826 no 3332 0.00453594631298684 4764 5238686
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.60984460181737 0.00682913955706646 no 3333 0.00452916804327719 4780 16486 A toxic proline analog.
SGTC_1668 st014914 51.6 µM -2.62755156369924 0.00651280357378604 no 3334 0.00430009032400778 4786 2839556
SGTC_119 0121-0043 24.815 µM -2.64889811795273 0.00614872808266723 no 3335 0.0040377336098496 4775 1092378
SGTC_2167 5876490 200 µM -2.6519171146158 0.00609872036394733 no 3336 0.00400180933261934 4756 686534
SGTC_594 1487-1584 10.8 µM -2.68089190810021 0.00563679959424215 no 3337 0.00367131146668674 4779 5013332
SGTC_2968 9090663 33.37 µM -2.69762371166987 0.00538444843481401 no 3338 0.00349181653548478 4745 25236811
SGTC_2522 biochanin a 4.94 µM -2.75026359906417 0.0046547662392816 no 3339 0.0029773670491164 4761 5280373 A possible chelator.
SGTC_425 3825-7017 13.1 µM -2.81228046880521 0.00390926412650556 no 3340 0.00245957948363679 4772 3397440
SGTC_3111 9122088 49.47 µM -2.8821518756554 0.00319897437419633 no 3341 0.00197484654095494 4784 16876704
SGTC_120 rhodamine 6G 52.259 µM -2.90764054267276 0.00297028888083752 no 3342 0.00182083332628168 4782 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2463 5473429 200 µM -2.90910397208818 0.00295761757403883 no 3343 0.0018123314624515 4790 5399405
SGTC_1157 4092-0394 27.6 µM -3.00663094171883 0.0022153317102355 no 3344 0.00132080128515271 4801 3659885
SGTC_2973 9094665 17.96 µM -3.00985254323019 0.00219398400560783 no 3345 0.00130687274984205 4769 25237061 YIL048W NEO1
SGTC_1814 st052110 31.539 µM -3.0310017762986 0.00205840886797232 no 3346 0.0012187190697664 4778 674163
SGTC_1107 amlodipine 47 µM -3.03605252688056 0.00202717718860843 no 3347 0.00119848801402488 4480 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_124 0136-0217 7.121 µM -3.10882695618493 0.00162247049600764 no 3348 0.000939158466120279 4801 3976905
SGTC_2763 lisinopril 49.32 µM -3.27088383505184 0.000972264869771117 yes 3349 0.000536059699585073 4787 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2311 7694451 200 µM -3.41234412375955 0.000610522065488438 yes 3350 0.000322033750982202 4795 2163142
SGTC_1521 st012942 49.4 µM -3.42252230095402 0.000590030463885585 yes 3351 0.000310215040649056 4778 24207259
SGTC_2475 5812728 15.03 µM -3.63812651693756 0.000280360363902652 yes 3352 0.000137314258953118 4798 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1830 st055982 50.3 µM -5.06473973990424 7.36564494024464e-07 yes 3353 2.04479339589052e-07 4810 455313 An antimicrobial agent.
SGTC_1111 tnp00062 510.699 nM -5.22589516609118 3.3643964235265e-07 yes 3354 8.66572706765818e-08 4805 676306
SGTC_1108 betulinic acid 729.144 nM -7.13717776347296 5.31694830613192e-12 yes 3355 4.76333059810056e-13 4805 64945 Apoptosis-inducing agent of unknown mechanism.