SGTCid condition conc unit YJL009W|YJL009W.score YJL009W|YJL009W.strain.pval YJL009W|YJL009W.strain.significant YJL009W|YJL009W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1875 nocodazole 6 µM 16.7752486339956 1.40514582492122e-39 yes 1 1.85152928320874e-63 4 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2783 7738165 71.43 µM 9.99695657133448 3.61241597161738e-15 yes 2 7.85763224750062e-24 1 17201110 SGTC_2601 securinine 100 µM 7.62487845440781 1.66239298113508e-09 yes 3 1.22132213410424e-14 3 442872 A GABA receptor antagonist. SGTC_435 c-PAF 6.7 µM 6.15214529024555 9.85826276403974e-07 yes 4 3.82208994576536e-10 7 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_212 3807-4682 38.772 µM 5.22987944149845 2.77829057097737e-05 yes 5 8.48103087711768e-08 16 3125501 YBL034C STU1 SGTC_2405 ticlatone 3.52 µM 5.06716338581082 4.75224944692609e-05 yes 6 2.01893840857955e-07 14 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2880 9042983 58.44 µM 5.01774586210568 5.57645642584565e-05 yes 7 2.61406362028593e-07 6 6464714 SGTC_2151 5563267 85.4165 µM 4.91040080355515 7.8539648956013e-05 yes 8 4.54452127557554e-07 11 5310824 SGTC_453 enantio-paf c16 10 µM 4.80282778999227 0.000109948030697335 yes 9 7.82202124710652e-07 13 13871343 A lipid and platelet activating factor SGTC_3146 9095609 49.47 µM 4.73218313561476 0.000136624797320029 yes 10 1.11058936411539e-06 2 17173999 SGTC_2451 5856223 45.7 µM 4.72509089450498 0.000139614562702525 yes 11 1.15006225644285e-06 5 2179896 SGTC_2883 9059145 45.46 µM 4.67128480918972 0.000164375673723336 yes 12 1.49660784988533e-06 2 16476510 SGTC_1916 st067606 49.2 µM 4.66100576219424 0.000169550794967952 yes 13 1.5733395644771e-06 3 19590279 SGTC_1863 st057641 20.1 µM 4.63314100320271 0.000184356684536296 yes 14 1.80079525792684e-06 2 3921635 SGTC_1773 st048542 73.5835 µM 4.4940084237479 0.000278136898167184 yes 15 3.49474307565584e-06 18 3237138 SGTC_2981 9013952 38.96 µM 4.46640081490592 0.000301380123997573 yes 16 3.9773257809971e-06 5 2996344 SGTC_441 propafenone 146 µM 4.39676953897756 0.00036827440616031 yes 17 5.49369482277813e-06 2 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_455 paf C-16 10 µM 4.22697818549645 0.000593367933138901 yes 18 1.18425309791775e-05 6 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2035 5154463 94.595 µM 4.15083234131058 0.000730915782406244 yes 19 1.6563418457433e-05 9 2769623 SGTC_1189 1431-2119 7.28 µM 4.10818476980038 0.000820242228298609 yes 20 1.9939051115942e-05 9 3107275 SGTC_2423 st077119 87.2 µM 4.09462686989743 0.000850678674110631 yes 21 2.11424409857282e-05 2 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1564 D-Arginine 115 µM 4.06413505414927 0.00092296258099991 yes 22 2.41054531619517e-05 8 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3201 9113999 49.47 µM 3.99380285631457 0.00111171077091763 no 23 3.25109664194111e-05 6 16649224 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 3.96022904761021 0.00121375111827471 no 24 3.74389545458598e-05 4 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3274 9138298 49.47 µM 3.9555810218946 0.00122853436296134 no 25 3.81744332944872e-05 5 17015756 SGTC_2026 5148700 152 µM 3.8744467711941 0.00151458592932407 no 26 5.34335989517054e-05 6 79838 SGTC_2920 7982904 15.77 µM 3.85029231664033 0.00161079533926713 no 27 5.89884667559826e-05 12 6456808 SGTC_2825 7998094 58.44 µM 3.77122034403078 0.00196598732088131 no 28 8.12255734119683e-05 14 2987815 SGTC_143 4032-1194 15.74 µM 3.76294149126866 0.00200701915178816 no 29 8.39632497245117e-05 19 1806963 SGTC_375 3970-0961 9.27 µM 3.75137927999453 0.00206562549022234 no 30 8.79322127355238e-05 9 2898222 SGTC_1802 st050112 57.9 µM 3.74127503293167 0.00211810857000324 no 31 9.15445118759367e-05 2 4662563 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.71953600335327 0.00223514677007481 no 32 9.97945484457276e-05 9 75037 A free radical scavenger. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.69083980152793 0.00239860877401759 no 33 0.000111757440084988 13 1377 SGTC_2481 5478948 45.16 µM 3.67508132996731 0.00249290509231809 no 34 0.000118886829368948 8 77792 SGTC_2727 riluzole 51.77 µM 3.66696009430278 0.00254279897749119 no 35 0.000122725541068517 7 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2887 9044784 58.44 µM 3.63821875751616 0.00272670808634565 no 36 0.000137265099614561 24 6465546 SGTC_69 0096-0274 206.684 µM 3.56345685960626 0.00326261744651111 no 37 0.00018300143429669 41 6741392 SGTC_1777 st045864 34.765 µM 3.55702303701683 0.0033128959763262 no 38 0.000187540637507492 4 4691462 SGTC_2400 5203494 178.7 µM 3.55040008791551 0.00336537912390043 no 39 0.00019232305331932 22 6777674 SGTC_3043 9092303 49.47 µM 3.54967660629026 0.00337115735084784 no 40 0.000192852327191463 8 25236084 SGTC_2993 9054257 71.4286 µM 3.51483418491437 0.00366021059653927 no 41 0.000220014321678397 40 6470217 YGL055W OLE1 SGTC_806 3966-4455 5.86 µM 3.5042110153643 0.00375266116086737 no 42 0.00022898115819287 12 714982 SGTC_594 1487-1584 10.8 µM 3.49390147286503 0.00384437888789228 no 43 0.000238008330376878 13 5013332 SGTC_1226 3909-7979 35.4 µM 3.48638918251881 0.00391247118287174 no 44 0.000244794089877403 8 6615510 SGTC_833 3852-0053 558 µM 3.43701688382699 0.00438750840426384 no 45 0.000294079469550351 9 3123681 SGTC_1953 st076800 12.1 µM 3.43004389207562 0.00445859780710723 no 46 0.000301741810212832 19 297591 SGTC_928 2764-0428 58.7 µM 3.42465525251173 0.00451423764632726 no 47 0.000307790006878399 29 662578 SGTC_2458 5808907 16.39 µM 3.36979541061198 0.00511696296096872 no 48 0.000376120059245554 9 2731747 SGTC_1318 1280-3875 124 µM 3.36412337706633 0.00518319402282794 no 49 0.000383936040569329 10 373245 SGTC_2367 9070478 135.38 µM 3.35124084464202 0.00533646203990498 no 50 0.000402251500868541 17 572802 SGTC_1090 efavirenz 20.7 µM 3.34293681708941 0.00543738164027696 no 51 0.000414483860687058 9 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1294 1000-1494 117 µM 3.33393264376821 0.005548723767807 no 52 0.000428136951983247 9 712797 YDL207W GLE1 SGTC_1175 0741-0056 27.6 µM 3.31157856967853 0.00583394750461723 no 53 0.00046385592371418 11 765927 SGTC_1804 st050076 49.1 µM 3.26255228552473 0.00650545876831391 no 54 0.000552069014449764 10 3895976 SGTC_822 1487-0950 154 µM 3.2574906359095 0.00657853882532624 no 55 0.000562009834351896 8 1958375 SGTC_3254 9136651 49.47 µM 3.23684933308771 0.00688412831323495 no 56 0.000604286013011421 12 16454030 SGTC_3145 9085516 49.47 µM 3.21434227841688 0.00723156434776178 no 57 0.000653718600994422 22 25236195 SGTC_1805 st050013 60.3 µM 3.16267043657397 0.00808828508983949 no 58 0.000781645981067386 6 4037144 SGTC_2844 9010103 25.97 µM 3.14306765526191 0.00843592596847807 no 59 0.000835935964232269 15 2480525 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 3.13944734288624 0.00850154499814701 no 60 0.000846334162674123 16 5355888 SGTC_2051 5263410 176 µM 3.13428874177637 0.0085958195693274 no 61 0.000861356247348793 10 227584 SGTC_313 3474-0040 5.03 µM 3.07289768265067 0.00979012408676063 no 62 0.00105995579669539 24 1043375 YIL048W NEO1 SGTC_1249 0481-0015 10.2 µM 3.05045568452681 0.0102615760467632 no 63 0.00114247198729871 15 4227577 SGTC_611 3453-1652 23.7 µM 3.04867051663821 0.0102999143893936 no 64 0.00114928212786902 38 1560575 SGTC_1675 st018485 24.5 µM 3.00342630452778 0.0113141617637431 no 65 0.00133479097406611 22 3323024 SGTC_1661 st013063 9.66 µM 2.99267268339776 0.0115676228674579 no 66 0.00138273083838116 12 721395 SGTC_3266 9136860 49.47 µM 2.99014110004879 0.0116280039581686 no 67 0.00139424302533117 25 4871271 YPR165W RHO1 SGTC_1282 0886-0010 32.4 µM 2.96837501462219 0.0121585365969068 no 68 0.00149689413643421 33 2836211 YNL267W PIK1 SGTC_952 1185-0122 232 µM 2.96777740332538 0.0121733941393284 no 69 0.0014998073707979 14 678600 SGTC_1028 k015-0029 4.8 µM 2.96717782014946 0.0121883165170328 no 70 0.00150273541473735 11 4588309 SGTC_3268 9137683 49.47 µM 2.95140482921045 0.0125866076886171 no 71 0.00158166006700765 11 1953228 SGTC_1331 1472-0049 76.2 µM 2.93400330999927 0.0130390459255334 no 72 0.00167310319953816 14 24051409 SGTC_3276 9139060 49.47 µM 2.9217559306426 0.0133658452900091 no 73 0.00174032089383788 16 4870619 SGTC_541 4513-1321 94 µM 2.91674869789547 0.0135014777053429 no 74 0.00176850310540238 23 747515 SGTC_721 1187-1332 279 µM 2.91148057879064 0.0136454578193996 no 75 0.00179860134664139 23 25730 SGTC_2755 lomerizine 42.69 µM 2.91124061687795 0.0136520475183618 no 76 0.00179998334623744 12 3949 A calcium channel blocker. SGTC_1545 lovastatin 49.4 µM 2.89798935174146 0.0140202342832972 no 77 0.00187781670244124 23 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3116 9124943 49.47 µM 2.89720573555274 0.0140422726004755 no 78 0.00188251380216799 15 41905195 YPL160W CDC60 SGTC_1574 spiramycin 23.7 µM 2.89643565538144 0.0140639593144185 no 79 0.00188714016598383 21 6419898 An antibiotic and protein synthesis inhibitor. SGTC_61 0978-8327 98.565 µM 2.89036677720674 0.0142358811722643 no 80 0.00192396294073193 20 6150059 YHR072W ERG7 SGTC_2089 5281248 129.67 µM 2.8891349463228 0.0142709971836205 no 81 0.00193151627261666 20 2737878 SGTC_380 3970-0968 6 µM 2.88214325293942 0.0144717273068737 no 82 0.00197490058663242 13 2891601 SGTC_2174 5790901 200 µM 2.88175126835505 0.0144830527019746 no 83 0.00197735889638275 23 786020 SGTC_989 1501-0895 10.3 µM 2.85720715669853 0.0152075523485394 no 84 0.00213693402025386 12 2830112 SGTC_2882 9058044 58.44 µM 2.84539137681573 0.0155672953409371 no 85 0.00221784425953492 22 18076804 SGTC_1887 st057648 70.8 µM 2.83716223928181 0.0158221325769276 no 86 0.00227582384456273 16 688672 SGTC_958 1222-0007 33 µM 2.83662038347853 0.0158390374145758 no 87 0.00227968932244196 23 7312461 SGTC_2710 st078562 53.7235 µM 2.83405126642041 0.015919399795268 no 88 0.00229809789294262 23 17250908 SGTC_1864 st057645 30.4 µM 2.81641525159058 0.0164805494443209 no 89 0.00242814267258131 14 688666 SGTC_1785 bathophenanthroline 24 µM 2.81115118209037 0.0166512909555139 no 90 0.0024682292332909 51 72812 An iron chelator. SGTC_1769 st044406 64.4 µM 2.80213295984368 0.0169473176071314 no 91 0.00253829731866658 39 670903 SGTC_1914 st062367 72.6 µM 2.79706594653782 0.0171156101860516 no 92 0.00257845031491399 19 978205 SGTC_1326 1431-2094 10.8 µM 2.77572623033893 0.0178401352678429 no 93 0.00275392827431905 17 616278 SGTC_1078 idebenone 36.1 µM 2.76148506634879 0.0183380721893681 no 94 0.00287695739658846 22 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1737 st035557 69.7 µM 2.74972384611811 0.0187581793471969 no 95 0.0029822754113894 23 5716916 SGTC_287 k060-0039 29.6 µM 2.73924633491854 0.0191393036528867 no 96 0.0030790107312801 27 5861974 SGTC_2152 5568786 200 µM 2.73808577069323 0.0191819219119786 no 97 0.00308989781954447 19 5399883 SGTC_2934 9036370 36.88 µM 2.73248897519658 0.0193885818265141 no 98 0.00314288875662889 14 6462800 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.72840982782416 0.0195403921885916 no 99 0.00318202434507501 23 5393153 SGTC_3140 9094243 49.47 µM 2.72261971632235 0.019757610822674 no 100 0.0032383281371809 20 19291112 SGTC_173 1273-0061 2.693 µM 2.70777857071266 0.0203237624438399 no 101 0.00338675991793562 56 2847414 YPL266W DIM1 SGTC_1613 st002381 52.1 µM 2.67636227950657 0.0215676895256729 no 102 0.00372130733753279 23 551167 SGTC_2715 st079500 56.4 µM 2.67626642537749 0.0215715811807206 no 103 0.00372237189560748 13 28246688 SGTC_1806 st050005 60.3 µM 2.66075773578302 0.0222090937825515 no 104 0.00389825159057852 21 5194765 SGTC_26 0302-0163 425.158 µM 2.65246389797071 0.0225565028258497 no 105 0.00399533363096961 32 3100915 SGTC_2393 9031399 185.94 µM 2.64901485868189 0.0227023178493162 no 106 0.00403633911572122 31 1526623 YDL150W RPC53 SGTC_2726 cimetidine 79.27 µM 2.6479404094727 0.0227479043149518 no 107 0.00404918994459056 12 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_908 3448-7491 47.7 µM 2.64223032993296 0.0229914664765979 no 108 0.00411810120109389 26 1203031 SGTC_1157 4092-0394 27.6 µM 2.63584254396106 0.0232665353367786 no 109 0.00419643333814459 22 3659885 SGTC_2391 6285546 200 µM 2.62146450413536 0.0238958250037829 no 110 0.00437764395895359 29 846083 SGTC_1049 3226-0134 66 µM 2.60123076436068 0.0248055856895836 no 111 0.00464449731276531 21 5702385 SGTC_3224 9130643 49.47 µM 2.59960933910595 0.024879729885762 no 112 0.00466649705427176 30 17644395 SGTC_3220 9131269 49.47 µM 2.58916492972317 0.0253617968044919 no 113 0.00481045012372561 17 17722206 SGTC_3350 9150499 3.57 µM 2.5871191943761 0.0254571293452422 no 114 0.0048391053367064 37 4910996 YPR165W RHO1 SGTC_1376 2910-0861 41.3 µM 2.57980855441584 0.0258002657083567 no 115 0.00494275508416329 24 1112859 SGTC_1221 2958-7315 257 µM 2.57124149744443 0.0262072911155971 no 116 0.00506673178561254 23 4562705 SGTC_3126 9127922 49.47 µM 2.57072140082162 0.0262321730803691 no 117 0.00507434665878721 66 45595682 SGTC_704 1310-0270 142 µM 2.56800953179503 0.0263622319150394 no 118 0.00511421717415122 24 5718033 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.56770382573467 0.0263769270518274 no 119 0.00511872917896221 34 5106787 A p450 inhibitor. SGTC_1064 honokiol 6.76 µM 2.56162370468585 0.0266706205310423 no 120 0.00520920655471394 35 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_197 4544-0043 41.561 µM 2.55961003168136 0.0267684888548096 no 121 0.00523948386909135 50 896523 SGTC_160 3453-0671 289.699 µM 2.55250492754262 0.0271162093732483 no 122 0.00534756983422351 26 5322268 SGTC_2917 7979103 53.79 µM 2.54481372202543 0.027496853420125 no 123 0.00546680236777541 28 2980565 SGTC_1990 st072050 59.8 µM 2.54071786755775 0.0277013718773955 no 124 0.00553125734673408 19 17233948 SGTC_2065 5221596 34.26 µM 2.53489279856994 0.027994417428322 no 125 0.00562408711118996 28 788581 SGTC_1590 st077108 57.8 µM 2.53343090024576 0.0280683660269051 no 126 0.0056476003802417 26 5489485 SGTC_3007 9078383 71.4286 µM 2.53173498280622 0.0281543559641291 no 127 0.00567498695917372 29 6496995 SGTC_573 3702-0553 84.7 µM 2.52266331183685 0.0286180591254681 no 128 0.00582349274644019 23 1222756 SGTC_2979 9012552 45.46 µM 2.52015458147609 0.0287474096210372 no 129 0.00586516532839108 18 17100905 SGTC_696 1560-0013 611 µM 2.51970911316297 0.0287704287778091 no 130 0.00587259260588838 37 1650269 SGTC_754 3474-0146 171 µM 2.51649801324626 0.0289368131299237 no 131 0.00592637842216834 30 24762078 SGTC_3355 9151058 44.0485 µM 2.51612267915922 0.0289563133058313 no 132 0.00593269368355928 23 17015728 SGTC_913 3487-1245 167 µM 2.51350252676702 0.0290927456276838 no 133 0.00597694608039737 37 4016153 SGTC_2833 9001315 45.46 µM 2.50074613900413 0.029764627118275 no 134 0.0061965989687518 31 2989378 SGTC_710 3448-4187 58 µM 2.49117870412798 0.0302769518101576 no 135 0.00636600317610466 26 3946412 SGTC_2153 5569715 200 µM 2.48611742992254 0.0305509193723845 no 136 0.00645726713537131 26 2054701 SGTC_1438 4092-1045 4 µM 2.48431520102932 0.0306489687287861 no 137 0.00649004297187187 29 1351342 SGTC_1441 4106-0040 13 µM 2.48132909880559 0.0308119996196982 no 138 0.00654467305386736 27 2904180 SGTC_2893 9048488 25.97 µM 2.47963553696259 0.0309047808610543 no 139 0.00657583678663425 37 6467338 SGTC_814 3342-0569 96 µM 2.47940075615883 0.0309176614835246 no 140 0.00658016739783942 23 4346283 SGTC_2304 7443016 91.4 µM 2.47675495971574 0.031063123449537 no 141 0.00662914462522905 22 939854 SGTC_538 2922-0838 53.3 µM 2.47576832241326 0.031117512053675 no 142 0.00664749093248247 34 777039 SGTC_1341 1486-1360 280 µM 2.46906355345236 0.0314892042645176 no 143 0.00677335784461794 26 3976547 SGTC_1231 0242-0792 125 µM 2.4602510194027 0.0319833193786299 no 144 0.0069419934875164 22 3707635 SGTC_1002 4049-0206 172 µM 2.44759978093371 0.0327038471804792 no 145 0.00719056495833886 38 4662749 SGTC_543 3844-1095 191 µM 2.44431346525166 0.0328931876131345 no 146 0.00725640539382999 35 4230703 SGTC_1780 st038448 24.544 µM 2.43328611980052 0.0335351392988353 no 147 0.00748123610822708 33 728868 YDL195W SEC31 SGTC_115 0527-0192 112.043 µM 2.43213562626242 0.0336027048365243 no 148 0.00750504280540219 62 4233931 SGTC_2438 5259590 200 µM 2.42878294261658 0.0338002385877645 no 149 0.00757479954149441 30 1201127 SGTC_1643 st009866 20.2 µM 2.42359191330794 0.0341079680870277 no 150 0.00768393190801107 39 3156273 YOR207C RET1 SGTC_2471 5466956 24.79 µM 2.42144840942246 0.034235707391504 no 151 0.00772939757781919 53 724419 SGTC_973 1325-0077 65.9 µM 2.42119438863794 0.0342508714557585 no 152 0.0077348012508522 17 2835149 SGTC_2427 5545055 42.75 µM 2.41999639067114 0.0343224617619767 no 153 0.00776033057654826 29 5372858 SGTC_1573 oleylamine 1.06 µM 2.41941293093169 0.0343573728226533 no 154 0.0077727909273087 25 5356789 An amine of the fatty acid oleic acid. SGTC_2787 5284540 71.43 µM 2.41555600234586 0.0345888851769347 no 155 0.00785560312277059 35 736958 SGTC_2302 7771753 200 µM 2.40559906888019 0.0351924794866896 no 156 0.00807298676524999 34 2203047 SGTC_2757 clomiphene 4.22 µM 2.38945706596182 0.0361893560786235 no 157 0.0084366479521644 55 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_349 k015-0014 24 µM 2.38777565973935 0.0362945107172966 no 158 0.00847534269381368 32 2196908 SGTC_2330 7979373 200 µM 2.38359136974043 0.0365572809542036 no 159 0.00857231391908262 43 1863007 SGTC_1513 0337-0559 19 µM 2.37817511454363 0.0368997269220713 no 160 0.00869928058761555 34 775073 SGTC_1447 4239-0816 81.9 µM 2.37112920139379 0.037349129474959 no 161 0.00886691536345945 37 1341554 SGTC_3148 9097893 49.47 µM 2.37102515238675 0.0373557992811906 no 162 0.00886941193895023 39 17174100 SGTC_598 3937-0236 20.2 µM 2.35860276829839 0.0381591253697267 no 163 0.00917193991422622 27 1379313 SGTC_1637 st007924 17.4 µM 2.35851202301735 0.0381650450817816 no 164 0.00917418270606474 25 683336 SGTC_1491 4138-0063 26.5 µM 2.35282271481744 0.0385376816168729 no 165 0.0093157573594373 23 23883227 SGTC_146 3448-8650 53.125 µM 2.34540119019261 0.0390282254265677 no 166 0.00950330785963172 44 2891488 YIL048W NEO1 SGTC_2775 cyproheptadine 69.59 µM 2.33658485716699 0.0396175565503048 no 167 0.00973039029751396 29 2913 A selective serotonin reuptake inhibitor. SGTC_222 nsc-310342 10.666 µM 2.33007269177911 0.0400574953767274 no 168 0.00990115473359102 12 432556 SGTC_3351 9150312 21.596 µM 2.32785512463824 0.0402082092990029 no 169 0.00995989890405026 56 4904905 SGTC_1272 0839-0021 27 µM 2.31872237750103 0.0408337656506361 no 170 0.0102050471857873 46 5027250 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.31863041295505 0.0408401047790275 no 171 0.0102075422999595 26 688664 SGTC_1103 duloxetine 36.1 µM 2.31586278253327 0.0410312517728986 no 172 0.0102828809853957 49 60835 A selective serotonin reuptake inhibitor. SGTC_3209 9113616 49.47 µM 2.31517225346869 0.0410790562384429 no 173 0.0103017535437757 37 16649353 SGTC_1998 st075797 76.8 µM 2.31033109463632 0.0414154732451925 no 174 0.0104349153477279 32 24208315 SGTC_195 4234-0266 16.654 µM 2.30077084552642 0.0420863820109258 no 175 0.0107022935988878 57 2303354 SGTC_2687 chenodiol 100 µM 2.29973543653734 0.0421595687771944 no 176 0.010731606601368 35 5702181 A cholesterol synthesis inhibitor. SGTC_1778 st046819 58.9 µM 2.29742240688341 0.0423234348279885 no 177 0.0107973423814206 40 671715 SGTC_1439 4092-1168 46 µM 2.28401034975972 0.0432837912027863 no 178 0.0111854613469229 23 2886240 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.28044979279464 0.0435416755841188 no 179 0.0112905126575305 40 368090 SGTC_2966 9084041 48.03 µM 2.25926185588476 0.0451020282977833 no 180 0.0119335505712337 26 17741380 SGTC_1003 4049-0218 100 µM 2.25282113580808 0.0455851638211198 no 181 0.0121352144905754 53 295161 SGTC_2943 9068529 45.32 µM 2.24821446543623 0.0459332681098008 no 182 0.0122812588618709 55 3270634 SGTC_174 3553-0389 74.3 µM 2.24746293992602 0.0459902594514421 no 183 0.0123052282446853 35 738071 SGTC_2292 7671323 168.05 µM 2.24627894227805 0.0460801622133203 no 184 0.0123430732503036 62 937504 SGTC_1767 st044992 70.3 µM 2.24438416678158 0.0462243290995957 no 185 0.0124038471743074 30 9600693 SGTC_1588 farnesol 29.9 µM 2.2344670357805 0.0469848080238407 no 186 0.0127261795877145 34 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.22416522415581 0.0477853763314849 no 187 0.0130686649305589 42 6708514 SGTC_1563 conessine 56.1 µM 2.22332841459346 0.0478508827305362 no 188 0.0130968314253641 18 441082 An anti-amoebic, histamine inhibitor. SGTC_652 0437-0092 114 µM 2.20848367288585 0.049024939365034 no 189 0.0136052873629898 27 3091274 SGTC_1233 0325-0408 14.2 µM 2.2061031918072 0.0492153325543373 no 190 0.0136883876464508 34 12874 SGTC_2606 farnesol 9.78 µM 2.20240590307767 0.0495122155768994 no 191 0.0138183246394742 56 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_432 NS 1619 61.3 µM 2.202063374183 0.0495397919803553 no 192 0.0138304160920221 40 4552 A K+/calcium channel activator. SGTC_1055 3448-0672 86 µM 2.19870906434383 0.0498104898541492 no 193 0.0139493080099825 54 748378 SGTC_1285 0929-0069 65.5 µM 2.1939326221282 0.0501979908614311 no 194 0.0141201268740301 35 1206237 SGTC_2806 7952793 58.44 µM 2.19132391616207 0.0504106411788335 no 195 0.0142141802792982 45 2972490 SGTC_805 3852-0218 479 µM 2.19001577681996 0.0505175448767982 no 196 0.0142615463235749 45 6615355 SGTC_1836 st055642 81 µM 2.18431538394893 0.0509855019853197 no 197 0.0144695405512684 46 8571 SGTC_397 arbidol 50 µM 2.18032965967767 0.0513147432685447 no 198 0.0146165170184484 43 131410 A RNA synthesis inhibitor. SGTC_1735 st034310 56.75 µM 2.17931088013957 0.0513991705197983 no 199 0.0146542907558368 48 871153 SGTC_3122 9126309 49.47 µM 2.17020439870433 0.052158749941137 no 200 0.014995682505237 48 17591206 SGTC_3143 9086658 49.47 µM 2.16715712618051 0.0524149072448327 no 201 0.0151114376327247 55 25236626 SGTC_3342 9147791 14.508 µM 2.16537014897152 0.0525655865869781 no 202 0.0151796750903197 28 1838168 SGTC_1848 st056003 16.4 µM 2.16525564867676 0.0525752530509672 no 203 0.0151840564052475 43 146492 SGTC_1198 1612-1005 86.7 µM 2.15938860277213 0.053072457995508 no 204 0.015410015680266 44 6998509 SGTC_999 SEC7.066 22.7 µM 2.15892955530566 0.0531115168857399 no 205 0.0154278162622442 59 740511 YDR170C SEC7 SGTC_1993 st073995 70.8 µM 2.15856087118545 0.0531429035468137 no 206 0.0154421255851213 40 3098394 SGTC_47 0149-0135 24.25 µM 2.15202879554136 0.0537014314460009 no 207 0.0156975432413052 42 5239155 SGTC_2584 androsterone 48.74 µM 2.15168910705183 0.0537306033504246 no 208 0.0157109243244169 77 2754130 A steroid. SGTC_2342 7990637 118.86 µM 2.15133255607591 0.0537612368774502 no 209 0.0157249801828113 61 2033102 YER133W GLC7 SGTC_1879 gemcitabine 100 µM 2.1385184056086 0.0548713904476508 no 210 0.0162373459643326 32 60750 A nucleoside analog which inhibits DNA replication. SGTC_2135 5326629 150.42 µM 2.13071636124737 0.0555561450680108 no 211 0.0165562581792438 37 5020077 SGTC_21 0849-0113 22.993 µM 2.12355705131817 0.0561904077295612 no 212 0.016853600059105 36 1560156 SGTC_3171 9103192 49.47 µM 2.12347866759977 0.0561973834207462 no 213 0.0168568806175001 22 13018434 SGTC_793 0488-0545 106 µM 2.11997885751461 0.0565095424325061 no 214 0.0170039141639126 43 292548 SGTC_2990 9074105 71.4286 µM 2.11898553685373 0.0565983883022286 no 215 0.0170458446331263 40 6502001 SGTC_70 0141-0289 43.283 µM 2.1168437499147 0.0567903312516021 no 216 0.017136555457491 65 352408 SGTC_3282 9108498 15.4605 µM 2.11450807935771 0.0570002337120766 no 217 0.0172359477205659 50 16459645 SGTC_20 0481-0013 4.944 µM 2.11141576564286 0.0572790734480046 no 218 0.0173682955686123 67 182045 SGTC_302 1094-0063 18.9 µM 2.11053118084689 0.0573590352579177 no 219 0.0174063141663793 70 5440289 SGTC_136 0097-0015 404.482 µM 2.10000282077098 0.0583175013083307 no 220 0.0178642964955327 44 4861337 SGTC_1337 1486-1011 40.3 µM 2.09616451193675 0.0586700407674697 no 221 0.0180337999251634 34 X1337 SGTC_976 1348-1067 47.6 µM 2.09004489468497 0.0592355701927039 no 222 0.0183068835117033 43 5310671 YGL099W LSG1 SGTC_735 3076-0345 636 µM 2.08786518789901 0.0594380317879893 no 223 0.0184049986034627 40 2888990 SGTC_2047 4141938 200 µM 2.08705531957315 0.0595133943017382 no 224 0.0184415671350133 34 3807862 SGTC_766 1391-0721 126 µM 2.08641417311688 0.0595731094550185 no 225 0.0184705611226379 50 1020919 YIL115C NUP159 SGTC_1444 4112-3581 28 µM 2.08579249323013 0.0596310563602429 no 226 0.0184987118521989 44 2877249 SGTC_2091 4-phenylthiadiazole 200 µM 2.08434850834517 0.0597658209173648 no 227 0.0185642389728648 43 270010 SGTC_2792 7535235 81.82 µM 2.08427395993797 0.0597727848604056 no 228 0.0185676272903556 65 1281891 SGTC_481 bay k-8644 50 µM 2.08145037209237 0.0600370187771123 no 229 0.0186963510635418 40 2303 A calcium channel antagonist. SGTC_2865 9030313 51.95 µM 2.07464903575741 0.060677249124043 no 230 0.0190095369711492 29 42562754 SGTC_1151 3909-8316 15.3 µM 2.07085367846766 0.0610368319889035 no 231 0.0191862360531218 46 800431 SGTC_923 1900-2434 73.3 µM 2.07051272233825 0.0610692165032679 no 232 0.0192021779527633 63 5910570 SGTC_638 3970-0837 4.09 µM 2.06643876710498 0.0614572064904417 no 233 0.0193935343013446 38 4118451 YLR208W SEC13 SGTC_2018 5133068 143 µM 2.06547030865426 0.0615497219135793 no 234 0.0194392610345935 59 785362 SGTC_2869 9037858 32.47 µM 2.06018345252473 0.0620566863682772 no 235 0.0196905031134716 28 27187042 SGTC_2603 homopterocarpin 100 µM 2.05799118829717 0.0622678590251114 no 236 0.0197954896377387 47 101795 A weak amylase inhibitor. SGTC_3027 9089541 49.47 µM 2.0540479631679 0.0626491054715711 no 237 0.0199855248795 54 9943819 SGTC_1448 4255-0083 152 µM 2.05354480882203 0.062697883011363 no 238 0.0200098843005669 52 5399660 SGTC_514 4466-0038 2.65 nM 2.04092051173466 0.0639314394971837 no 239 0.0206293643221111 93 5722064 SGTC_2582 agaric acid 100 µM 2.04008734316214 0.0640135100527557 no 240 0.0206708135564297 76 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3002 9075603 71.4286 µM 2.03857286838125 0.0641629018547213 no 241 0.0207463376788199 53 20105405 SGTC_1420 4'-methoxyflavone 42 µM 2.03741155363371 0.0642776404928482 no 242 0.020804408514098 34 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1520 flindersine 88 µM 2.02790647828275 0.0652227506954786 no 243 0.0212848969208349 59 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1201 1889-3372 45.9 µM 2.01401118203295 0.0666237476192949 no 244 0.0220041797501774 51 5392199 SGTC_3196 9111891 49.47 µM 2.01198327618205 0.0668301449999417 no 245 0.0221108499688485 54 18891510 SGTC_927 2425-1185 123 µM 2.00617616314893 0.0674239217337156 no 246 0.0224187280620793 58 730375 SGTC_606 k015-0008 38.6 µM 2.0056411209781 0.0674788342420512 no 247 0.0224472756466911 44 1970475 SGTC_2351 9026858 72.31 µM 2.00237254580759 0.0678150458216106 no 248 0.0226223394602743 63 1409300 SGTC_2072 5231554 129 µM 2.00227518886801 0.0678250799398691 no 249 0.0226275714677725 45 789545 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.99360922938739 0.068722841311186 no 250 0.0230973879802337 54 688801 SGTC_2070 5230947 200 µM 1.99232558051231 0.068856598209702 no 251 0.0231676733817398 39 2835538 SGTC_2228 7354201 200 µM 1.99149126418715 0.0689436419749978 no 252 0.0232134523413576 41 753451 SGTC_3356 9151811 4.48 µM 1.9906222511598 0.0690343957844625 no 253 0.0232612160525108 50 1859254 YPR165W RHO1 SGTC_2734 clemastine 41.6 µM 1.98965518747664 0.0691354975463198 no 254 0.0233144661625371 55 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2060 5238662 140 µM 1.98936408140835 0.0691659535877928 no 255 0.0233305156173518 42 790130 SGTC_2995 9067767 71.4286 µM 1.98915146771862 0.0691882041468962 no 256 0.0233422434524123 41 11673567 SGTC_140 0062-0056 502.533 µM 1.98604015262702 0.069514442334311 no 257 0.0235144328258315 43 3758964 SGTC_422 cantharidin 155 µM 1.98567868157863 0.0695524212033067 no 258 0.0235345068092934 52 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3241 9133421 49.47 µM 1.98567078491258 0.0695532510647722 no 259 0.0235349455046941 22 17018221 SGTC_2112 5488546 200 µM 1.9829864791891 0.0698357870689291 no 260 0.0236844699190561 60 600757 SGTC_2526 patulin 37.61 µM 1.97728424051362 0.07043890521455 no 261 0.0240047550166852 68 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2296 7971656 126.45 µM 1.97376556381623 0.0708130639630239 no 262 0.0242042030872179 45 666570 SGTC_3311 9131146 2.8755 µM 1.97256661956892 0.0709409019836239 no 263 0.0242724796175954 78 4900406 YPR165W RHO1 SGTC_1772 st048439 82.2 µM 1.96787517984874 0.0714428335443515 no 264 0.0245412006275429 54 2927068 YDL195W SEC31 SGTC_2945 9067681 61.76 µM 1.96682353454431 0.071555720887148 no 265 0.0246017791869794 63 16456930 SGTC_714 4296-0578 26.1 µM 1.96616662214905 0.071626305615458 no 266 0.0246396833421356 36 1589775 SGTC_803 4488-1585 147 µM 1.96489783628415 0.0717627868833985 no 267 0.0247130316105467 46 747204 SGTC_870 0573-2213 57.6 µM 1.96440935852897 0.0718153848041839 no 268 0.0247413192106515 43 3916321 SGTC_355 1311-2252 105 µM 1.95159476347664 0.0732058113026794 no 269 0.0254931677244489 47 5338538 SGTC_1771 st048882 4.1505 µM 1.95156210214967 0.0732093812948296 no 270 0.0254951081823833 63 4580403 SGTC_1443 4112-3303 14 µM 1.94769081183626 0.0736334705212245 no 271 0.0257259850897101 49 704433 SGTC_1283 0922-0125 16.4 µM 1.94761071667353 0.0736422645158698 no 272 0.0257307802406174 44 3360884 SGTC_2319 6033012 152.6 µM 1.94641829865119 0.0737732802284665 no 273 0.0258022566432168 47 847246 SGTC_1645 Cervolide 78 µM 1.9447339252934 0.0739586525076129 no 274 0.0259035051007305 53 23173 A fragrance. SGTC_1017 4239-0030 168 µM 1.94462071429759 0.0739711246006372 no 275 0.0259103221711782 53 1149593 SGTC_2234 tolnaftate 200 µM 1.94352745292159 0.0740916484108716 no 276 0.0259762308533062 20 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_248 streptozotocin 5.23457 mM 1.94209519246099 0.0742497712362284 no 277 0.0260627887055999 73 5300 DNA alkylating agent. SGTC_1094 duloxetine 25.4 µM 1.93971554782927 0.0745130557360545 no 278 0.0262071344945045 45 60834 A selective serotonin reuptake inhibitor. SGTC_2144 5628481 200 µM 1.93351326828292 0.0752026266206402 no 279 0.0265865000872716 33 2818399 SGTC_1502 4534-4282 27.7 µM 1.92983419964434 0.0756139592189363 no 280 0.0268136922546709 37 3278949 SGTC_235 0330-0087 5 mM 1.92791428681719 0.0758292916553252 no 281 0.0269328941938763 49 46494818 YHR062C RPP1 SGTC_295 k015-0027 31 µM 1.91353815458268 0.077456548224241 no 282 0.0278395969218234 45 3887424 SGTC_2895 9054447 58.44 µM 1.91200397904019 0.0776317581943043 no 283 0.027937841843376 43 2697450 SGTC_2274 7947094 46.08 µM 1.91176311773217 0.0776592929811631 no 284 0.0279532922203761 58 2971028 SGTC_3212 9128307 49.47 µM 1.90389302539534 0.0785630708346891 no 285 0.0284620588270146 59 27243542 SGTC_2881 9058953 51.95 µM 1.89202407014601 0.0799411128448141 no 286 0.0292438869181652 60 17122249 SGTC_578 3460-0051 92 µM 1.89051629565215 0.0801174730524095 no 287 0.029344471627963 73 2876744 SGTC_428 3448-4153 16.5 µM 1.88181716302571 0.0811407345117399 no 288 0.0299304223344271 65 3834874 SGTC_2183 6420625 130.508 µM 1.88141826355746 0.0811878916431108 no 289 0.0299575221873323 78 2897619 SGTC_864 0469-0573 172 µM 1.88025206097257 0.0813258764819392 no 290 0.0300368666969072 62 689425 SGTC_2105 5350118 200 µM 1.87732806201316 0.0816726211691028 no 291 0.0302365721977233 67 2133313 SGTC_1400 3771-8998 51.5 µM 1.87265606421307 0.0822289651175516 no 292 0.0305579470448644 23 670767 SGTC_2907 7721985 69.9 µM 1.86866965238683 0.0827059218510885 no 293 0.0308343943350763 60 3267881 SGTC_2557 derrustone 83.84 µM 1.86768164515502 0.0828244539044031 no 294 0.030903229274611 60 629853 An antioxidant. SGTC_2868 9035608 32.47 µM 1.86382421303423 0.0832884570969172 no 295 0.0311731971565653 52 6462614 SGTC_3275 9138069 49.47 µM 1.86302880526319 0.0833843777525547 no 296 0.0312291068212258 65 17617007 SGTC_2067 5224629 34.075 µM 1.86287208981963 0.0834032863349558 no 297 0.0312401322133089 64 2835000 SGTC_1514 1189-1591 158 µM 1.86035012363952 0.0837080188660139 no 298 0.0314180031602839 64 767698 YMR146C TIF34 SGTC_2561 acetosyringone 100 µM 1.85991622102958 0.0837605321229525 no 299 0.031448689999865 62 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_250 brefeldin a 552.239 µM 1.85825701034747 0.0839615670869118 no 300 0.0315662627746568 29 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3323 9138564 53.9225 µM 1.85462370320975 0.084403054577713 no 301 0.031824990429556 63 43912313 YNL103W MET4 SGTC_223 busulfan 5 mM 1.85410935658596 0.0844656939367496 no 302 0.0318617581862237 54 2478 A DNA alkylator. SGTC_707 0865-0008 204 µM 1.85299305661572 0.0846017617600231 no 303 0.0319416769329711 67 723043 SGTC_2028 5153890 36.43 µM 1.85039156707279 0.0849194999737828 no 304 0.0321285667826029 82 2830968 YPR165W RHO1 SGTC_1934 st074720 32.6 µM 1.83405969391108 0.086934691216012 no 305 0.0333225668132499 74 17250992 SGTC_900 1112-0045 141 µM 1.83372987576555 0.0869757523673132 no 306 0.0333470507648205 50 56211 YIL048W NEO1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.82842201789275 0.0876385552273777 no 307 0.0337431197045355 56 5357218 A potent inhibitor of glutathione S-transferases. SGTC_832 4083-0019 164 µM 1.82251797191773 0.0883802245277092 no 308 0.0341882146662405 108 1990758 SGTC_2448 5185112 27.17 µM 1.82124484196722 0.0885407670189058 no 309 0.0342848234212222 61 5718189 SGTC_258 haloperidol 50.781 µM 1.8187728927259 0.0888531016264902 no 310 0.0344730428020607 94 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_957 1187-1561 14.1 µM 1.81583563864359 0.0892252938349335 no 311 0.0346977942994461 67 1538454 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.80931730125709 0.0900554022633163 no 312 0.0352008613202866 60 688664 SGTC_2214 7179297 48.276 µM 1.8068852281735 0.0903665915454424 no 313 0.0353900881074475 36 769744 SGTC_252 miconazole 1.30953 nM 1.80385959281591 0.0907548422297233 no 314 0.0356266604246773 95 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2512 diallyl trisulfide 49.23 µM 1.79352600196359 0.0920901862352798 no 315 0.0364444283922936 64 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_681 1642-0006 26.6 µM 1.78072112128993 0.0937649912057378 no 316 0.0374790104571057 68 4446530 SGTC_962 1254-0300 21.5 µM 1.77243355121326 0.09486087931328 no 317 0.0381613082519229 58 7340576 SGTC_3066 9117245 49.47 µM 1.77216631308916 0.0948963733441668 no 318 0.0381834768782292 44 17176980 SGTC_980 1473-0395 201 µM 1.77215834424625 0.0948974319000953 no 319 0.038184138091468 64 768876 SGTC_2416 tofa 880 nM 1.77049480679255 0.0951186014778825 no 320 0.038322374372842 53 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_795 0685-0265 78 µM 1.76890319577707 0.095330563478411 no 321 0.0384550153971432 96 302754 SGTC_88 0180-0332 8.668 µM 1.76742387178239 0.0955278833280909 no 322 0.0385786339974544 78 3101745 SGTC_12 0849-0099 9.267 µM 1.7666636276518 0.095629405457317 no 323 0.0386422890891713 69 6071388 SGTC_124 0136-0217 7.121 µM 1.76660226198718 0.0956376036192323 no 324 0.0386474309546995 101 3976905 SGTC_2961 9083290 32.55 µM 1.75191403963014 0.0976147866357304 no 325 0.0398942950193795 56 17741490 SGTC_2665 lovastatin 100 µM 1.750316427369 0.0978316356436314 no 326 0.0400318639166753 55 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_838 0109-0203 71.4 µM 1.74939359473875 0.0979570554419786 no 327 0.0401115036512065 65 759422 SGTC_3053 9095903 49.47 µM 1.74340346156673 0.0987740247346828 no 328 0.0406315820386139 72 17174018 SGTC_2202 7226349 200 µM 1.74148653322814 0.0990365168199504 no 329 0.0407991658938644 47 844334 SGTC_1677 st019204 53.9 µM 1.7402131794752 0.0992111636786466 no 330 0.0409107961295061 64 3945625 SGTC_1817 st052116 64.4 µM 1.74002194890039 0.0992374113503705 no 331 0.0409275819883959 48 4361398 SGTC_1093 fluphenazine 7.97 µM 1.73432494136841 0.100021694064175 no 332 0.0414302222496279 72 6602611 An atypical antipsychotic. SGTC_3120 9124077 49.47 µM 1.73333355154248 0.100158635540412 no 333 0.0415182003077822 54 18774327 YGL155W CDC43 SGTC_845 0330-0138 4.51 µM 1.73161938282175 0.100395737890776 no 334 0.0416706764117257 74 9039800 SGTC_2173 5763948 167 µM 1.73038184385835 0.100567167632242 no 335 0.041781037765042 73 2867177 SGTC_1951 sophoraflavanone G 9.2 µM 1.72942638898792 0.100699667759698 no 336 0.0418664052207766 66 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2442 5158906 48.48 µM 1.72778137536503 0.100928092433886 no 337 0.0420137138559487 54 1893835 SGTC_2031 5180455 200 µM 1.72604315418611 0.101169870026138 no 338 0.0421698246993482 62 29949 SGTC_1329 1447-1697 50.6 µM 1.72341869306778 0.101535718328776 no 339 0.0424064184456691 62 2840515 SGTC_54 0159-0055 9 µM 1.7221117491147 0.101718264487058 no 340 0.0425246385802694 73 3319099 SGTC_1016 4226-1401 38 µM 1.72200305178439 0.101733457439246 no 341 0.0425344828334965 81 2901613 SGTC_579 4491-1009 110 µM 1.71760288478 0.102349869765066 no 342 0.0429345368967117 91 1271041 SGTC_3185 9108267 49.47 µM 1.71516167586436 0.102693024062204 no 343 0.0431577945581058 58 4910486 SGTC_701 4424-0219 185 µM 1.71158684901877 0.103197035677344 no 344 0.0434864167818882 66 2911779 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.71109152719269 0.103267012098058 no 345 0.0435321090128747 74 688761 SGTC_2264 7948757 110.76 µM 1.70862585766141 0.103615861346664 no 346 0.0437601378831056 50 2971411 SGTC_2482 5981709 142.65 µM 1.70639498651775 0.103932226864553 no 347 0.0439672817122574 89 877755 SGTC_1163 k060-0048 49.9 µM 1.70310367956562 0.104400253733666 no 348 0.0442743337378433 70 6809982 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.70097052036358 0.104704405485561 no 349 0.0444742614845738 71 3256 An antibiotic and ribosome inhibitor. SGTC_2656 pseudo-anisatin 100 µM 1.70090406113929 0.104713891723465 no 350 0.0444805019590956 50 6708809 A neurotoxin. SGTC_149 3970-0822 46.1 µM 1.69870968762478 0.105027461240506 no 351 0.0446869486060456 90 3114250 YBL034C STU1 SGTC_2349 9023730 187.07 µM 1.69730736011992 0.105228205346992 no 352 0.0448192832354793 57 4126287 SGTC_2984 9022109 38.96 µM 1.68444809800695 0.107081973411937 no 353 0.0460475510144821 78 6459207 SGTC_2560 caryophyllene 100 µM 1.68149578684926 0.107510877755678 no 354 0.0463333270577757 82 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1425 4048-4433 7.33 µM 1.68101064211546 0.107581476637238 no 355 0.0463804237403899 81 23734946 SGTC_1009 4106-0057 9.87 µM 1.67883261165051 0.107898838057778 no 356 0.0465923354622649 87 2928005 SGTC_1873 rapamycin 2 nM 1.67056698460227 0.109109358529112 no 357 0.0474036191333299 70 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1647 st011722 22.4 µM 1.67049141961829 0.109120470036677 no 358 0.0474110878303892 91 2854783 SGTC_850 0388-0143 75.9 µM 1.67028197560666 0.109151272132892 no 359 0.0474317938004268 74 67273 SGTC_686 1319-0111 510 µM 1.67016449174028 0.109168552752006 no 360 0.0474434116150036 94 4562600 SGTC_2725 haloperidol 53.21 µM 1.66680426138396 0.109663639138501 no 361 0.0477766663133921 101 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_700 3453-2283 142 µM 1.66609403397065 0.109768487978776 no 362 0.0478473433233362 79 565664 SGTC_831 k061-1017 217 µM 1.66337390808332 0.110170717885418 no 363 0.0481188063249409 100 1240153 SGTC_416 estradiol valerate 100 µM 1.66107761349485 0.110511097176369 no 364 0.0483489299508594 85 13791 A steroid. SGTC_1713 st033146 12.748 µM 1.66086596803092 0.110542507243499 no 365 0.0483701842749228 81 674619 SGTC_2305 7443522 69.23 µM 1.65977118937006 0.110705084290664 no 366 0.0484802458682859 84 5415886 SGTC_424 splitomicin 100 mM 1.65753916836774 0.111037074964834 no 367 0.0487052583921341 68 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1550 gossypolone 36.6 µM 1.6555677724507 0.111330892775892 no 368 0.0489046905678547 81 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1681 tripelennamine 100 µM 1.64945318125013 0.112245753429582 no 369 0.0495274136437604 69 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_860 0443-0016 25.1 µM 1.64924315736039 0.112277272210376 no 370 0.0495489148290436 101 5337942 SGTC_1565 sinapyl alcohol 95.1 µM 1.64843463526448 0.112398668069249 no 371 0.0496317567867618 81 5280507 A phenol propionate derived from cinnamic acid. SGTC_1865 st057639 52.2 µM 1.64829994817093 0.112418899823076 no 372 0.0496455676899517 86 688818 SGTC_2290 7904846 200 µM 1.64816303249276 0.112439469005916 no 373 0.0496596102566311 86 2962154 SGTC_1082 camptothecin 424.86 nM 1.64489000727287 0.112931984341691 no 374 0.0499962480045179 96 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_931 2812-0076 566 µM 1.63966038811134 0.113722114765568 no 375 0.0505378997313772 87 3450959 SGTC_3321 9137793 26.8275 µM 1.63917047190985 0.113796336375835 no 376 0.0505888808003247 98 4904192 SGTC_1257 0669-0121 16 µM 1.63622598675809 0.114243149038535 no 377 0.0508961498013982 89 4307855 SGTC_776 4476-4378 112 µM 1.63388204804454 0.114599723480906 no 378 0.0511418099409598 73 2892008 SGTC_1755 st041960 45.185 µM 1.631097291238 0.115024386521484 no 379 0.0514348960841864 93 2257073 SGTC_2161 5662504 8.5105 µM 1.62787198872497 0.115517628039387 no 380 0.0517760160139331 82 2859334 SGTC_404 fumagillin 50 µM 1.62570427999402 0.11584997635802 no 381 0.0520062895700152 86 12015870 A methionine aminopeptidase binder. SGTC_3193 9111931 49.47 µM 1.62064848090333 0.116627757382401 no 382 0.0525465242431457 84 17087244 SGTC_747 3448-8087 38.7 µM 1.6203599850466 0.116672250816193 no 383 0.0525774851460644 75 5168703 SGTC_3170 9103054 49.47 µM 1.61942285754798 0.116816862867276 no 384 0.0526781560441617 84 16432970 SGTC_1037 k284-1091 78.7 µM 1.61908530292149 0.116868983442527 no 385 0.0527144552890767 75 3334711 SGTC_1107 amlodipine 47 µM 1.61902903371884 0.116877673366919 no 386 0.0527205081786476 70 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_719 2810-4230 27.3 µM 1.61698213939073 0.117194096535259 no 387 0.0529410681576921 59 721079 SGTC_2313 7726885 200 µM 1.61122425318351 0.118087443696146 no 388 0.0535654267238942 92 726423 SGTC_2146 5545642 200 µM 1.60734019470904 0.118692776644035 no 389 0.0539898807558838 86 825326 SGTC_2896 9052656 71.43 µM 1.60496080043723 0.119064687837962 no 390 0.0542512158202857 119 6469436 SGTC_321 4534-3890 65.3 µM 1.60267016697727 0.119423501857859 no 391 0.0545037466744593 88 699746 SGTC_121 0557-0495 61.343 µM 1.60243393591578 0.119460549392373 no 392 0.054529842760209 95 3104427 SGTC_2857 9024691 58.44 µM 1.60098355858916 0.119688186212456 no 393 0.0546902803751922 90 16478292 SGTC_1901 st060216 58.6 µM 1.59995294408116 0.119850127040003 no 394 0.0548045113778418 77 688792 SGTC_2762 leflunomide 42.06 µM 1.58920443800926 0.121548254421745 no 395 0.0560071224263021 104 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2005 4024620 188 µM 1.58792793092803 0.121751044253972 no 396 0.0561513183697554 86 236743 SGTC_1807 st050092 58.9 µM 1.58464255634382 0.122274061842391 no 397 0.0565237850797706 88 5008496 SGTC_2260 7964312 200 µM 1.58330839319649 0.122486904551563 no 398 0.05667559541463 83 231951 SGTC_2629 bisabolol 100 µM 1.58295645972736 0.122543092772406 no 399 0.0567156943379592 120 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_951 1171-0579 82.7 µM 1.58262936627528 0.122595331353157 no 400 0.0567529830512093 109 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3091 9116372 49.47 µM 1.58230525426105 0.122647109190287 no 401 0.0567899509249541 79 17169793 SGTC_1357 1503-1303 39.5 µM 1.58181621529618 0.122725263620253 no 402 0.0568457660877165 84 292895 SGTC_3263 9137018 49.47 µM 1.58000686877875 0.123014723078568 no 403 0.0570526467338835 104 43844957 SGTC_2145 5634607 200 µM 1.57562590621577 0.123717571353329 no 404 0.0575560210819712 71 308662 SGTC_841 0251-0215 91.2 µM 1.57251196715764 0.124218854409745 no 405 0.057915933002752 90 3888614 SGTC_1899 st063254 59.6 µM 1.56821988284313 0.124912121903743 no 406 0.058414912881125 89 3093813 SGTC_343 4130-2827 29.8 µM 1.56666515437427 0.125163910944918 no 407 0.0585964898764151 79 1118244 SGTC_368 fentichlor 4.58 µM 1.56615843256488 0.125246051320769 no 408 0.0586557656499955 82 7329 A pesticide. SGTC_2022 5136654 200 µM 1.56366035158783 0.125651544159592 no 409 0.0589486767786258 109 1713771 SGTC_14 0354-0009 295 µM 1.56325210711191 0.125717898087878 no 410 0.0589966541747976 95 1713507 SGTC_2657 nystatin 74.44 µM 1.5587114340945 0.126457563568432 no 411 0.0595323471442068 79 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3228 9131799 49.47 µM 1.55652352887871 0.126815048731272 no 412 0.0597918260689695 99 17015818 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.55371942122476 0.127274244050587 no 413 0.0601256792006711 97 676296 Flavone; oxidizing agent. SGTC_1123 mangostin 811.285 nM 1.55326670358058 0.127348488537893 no 414 0.0601797157015549 48 5281650 An antioxidant. SGTC_2068 5226020 147 µM 1.54869521067648 0.128099889313897 no 415 0.0607275028692632 99 1810509 SGTC_1127 asiatic acid 681.4 nM 1.5485373090626 0.128125897972643 no 416 0.0607464931526974 87 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2813 7971799 71.43 µM 1.54481794615675 0.128739591233721 no 417 0.0611951525853859 101 2234054 SGTC_752 1896-0090 130 µM 1.54440087547831 0.128808534664561 no 418 0.0612456240470481 93 772567 SGTC_2644 guaiazulene 100 µM 1.5435814763033 0.128944059164652 no 419 0.0613448776765496 60 3515 A coloring agent. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.53886480575291 0.129726095580046 no 420 0.061918652367215 83 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3006 9075424 71.4286 µM 1.53816723826814 0.129842032338235 no 421 0.0620038645983024 92 7465181 SGTC_630 4356-0227 183 µM 1.53685101469717 0.13006098601034 no 422 0.0621648987383451 128 779312 SGTC_1401 3807-4679 7.6 µM 1.53633365551494 0.130147118587616 no 423 0.0622282846013944 99 3291456 SGTC_1486 3970-0793 4.53 µM 1.53436378361024 0.130475434076382 no 424 0.0624700910573864 99 2844330 SGTC_119 0121-0043 24.815 µM 1.53224866261045 0.130828595222122 no 425 0.0627305421324407 133 1092378 SGTC_2240 6690706 185.951 µM 1.52966709953181 0.131260532631014 no 426 0.0630495756481081 76 805876 SGTC_1298 1079-1278 263 µM 1.52957261655433 0.131276359826787 no 427 0.0630612759272292 80 2840950 SGTC_679 0422-0091 41.4 µM 1.529522013177 0.131284837129088 no 428 0.0630675430809047 105 627384 YHR062C RPP1 SGTC_2270 7924575 90.91 µM 1.52754643301688 0.131616090586431 no 429 0.0633125951303494 98 1262135 SGTC_640 3381-0960 37.1 µM 1.52729274190239 0.131658669749833 no 430 0.0633441167489306 101 1745025 SGTC_722 3534-0461 190 µM 1.51555549160428 0.133639033152295 no 431 0.0648158943348519 73 658262 SGTC_1409 3909-8004 61.9 µM 1.51552528375901 0.133644156244686 no 432 0.0648197161741613 93 2119279 SGTC_48 0382-0018 55 µM 1.51468216182566 0.133787199793926 no 433 0.0649264569724254 65 762596 SGTC_3237 9133362 49.47 µM 1.51248790253009 0.134159969718679 no 434 0.0652048939436989 89 43845137 SGTC_1146 3579-1023 7 µM 1.5110944078752 0.134397072491355 no 435 0.0653821996387416 101 X1146 SGTC_871 0574-0004 149 µM 1.51034874051521 0.134524065713044 no 436 0.0654772304589049 117 9551173 SGTC_2685 mycophenolic acid 18.85 µM 1.50906107310396 0.134743559850602 no 437 0.065641588093875 76 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2082 5219693 150 µM 1.50892723272298 0.134766388201431 no 438 0.065658689790804 87 2834649 SGTC_1632 st005650 90 µM 1.5088681986586 0.134776458130988 no 439 0.0656662340729787 101 2759605 SGTC_3097 9117246 49.47 µM 1.5077110662162 0.134973944042553 no 440 0.0658142460093153 88 16423892 SGTC_3310 9130229 44.1445 µM 1.5074322545273 0.135021558038432 no 441 0.0658499481953037 92 7761258 SGTC_1349 flufenamic acid 69 µM 1.50389746929485 0.135626208965817 no 442 0.066303884372866 94 3371 A non-steroidal anti-inflammatory. SGTC_2259 7964009 200 µM 1.50335293323605 0.135719520485594 no 443 0.0663740284431102 74 313134 SGTC_2044 5102272 200 µM 1.49996468897709 0.136301116877404 no 444 0.0668117747887655 98 592666 SGTC_2239 6685329 187.64 µM 1.4997365793331 0.136340333359847 no 445 0.0668413256212395 73 805680 SGTC_789 1309-1135 70.6 µM 1.49792451059912 0.136652137434448 no 446 0.0670764323449783 77 3092424 SGTC_2213 7173844 200 µM 1.49565486335958 0.137043364727374 no 447 0.067371809120574 94 892728 SGTC_1711 st032263 62.8 µM 1.4951161399565 0.13713633870039 no 448 0.0674420671679341 88 3958979 SGTC_2496 diffractaic acid 79.83 µM 1.49345265753249 0.137423697767944 no 449 0.0676593689757159 103 94870 An apoptosis inducer which activates caspases. SGTC_3003 9075612 71.4286 µM 1.49052208241281 0.137930940916169 no 450 0.0680435073044403 95 6501993 SGTC_3285 9112818 20.8695 µM 1.48865800483833 0.138254251426949 no 451 0.0682887244204295 125 17017947 YPR165W RHO1 SGTC_3214 9129694 49.47 µM 1.48780000376553 0.138403238879068 no 452 0.0684018223491512 116 17158655 SGTC_2087 5276107 200 µM 1.48383857620181 0.139092538925616 no 453 0.0689258751846697 95 144405 SGTC_1925 st057770 10.1 µM 1.48042287322308 0.139688754304248 no 454 0.0693802147715159 90 5989122 SGTC_853 0419-0306 21 µM 1.47815142338124 0.140086199427639 no 455 0.0696836263085854 121 762713 SGTC_1173 0443-0020 122 µM 1.47784016698 0.140140721061031 no 456 0.0697252821954565 99 5331295 SGTC_654 1124-0271 80.9 µM 1.47701637568376 0.140285091095792 no 457 0.0698356238572449 103 5403748 SGTC_2433 5607874 27.82 µM 1.47428694622411 0.140764147198668 no 458 0.0702021741723337 82 2252428 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.47411314957285 0.140794688682986 no 459 0.0702255643113158 81 364106 SGTC_998 3996-0085 177 µM 1.47361895120063 0.140881559296767 no 460 0.0702921079472053 94 715391 SGTC_1342 1486-1464 234 µM 1.47296656591326 0.140996291814232 no 461 0.0703800256367161 105 3253938 SGTC_1500 4488-1866 171 µM 1.47224365354784 0.141123501662045 no 462 0.070477546524895 96 2900003 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.46999669563718 0.141519392374398 no 463 0.0707813244631798 93 2374 Ca(2+)-ATPase inhibitor. SGTC_1227 3909-8010 46.6 µM 1.46830932279501 0.141817184277028 no 464 0.0710101098500974 83 15982272 SGTC_1225 1216-0074 20.6 µM 1.46722785726838 0.14200826708694 no 465 0.07115704062774 88 4241466 SGTC_691 1548-0686 185 µM 1.46687407513062 0.142070814233492 no 466 0.0712051570480627 128 46495133 SGTC_3056 9094900 49.47 µM 1.46617122431468 0.142195130522718 no 467 0.0713008229380139 91 25236784 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.46436825040168 0.142514366926819 no 468 0.0715466791042851 101 165521 SGTC_1703 st026983 48.3 µM 1.46422711036373 0.142539377767834 no 469 0.0715659525869088 77 1104023 SGTC_1730 st033808 45.1 µM 1.46057810336241 0.143187033696612 no 470 0.0720656295227902 95 1045166 SGTC_2203 7227154 166.4 µM 1.45990028626686 0.143307556840972 no 471 0.0721587402794527 77 896304 SGTC_37 0566-0070 1.56 µM 1.45897583845392 0.143472043975064 no 472 0.0722858789491759 100 1626686 SGTC_1646 st011709 75.6 µM 1.45701678725039 0.143821039343896 no 473 0.072555873176331 110 5757843 SGTC_256 clotrimazole 625 nM 1.45602053699877 0.143998735949269 no 474 0.0726934712174413 105 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2017 5132927 60.65 µM 1.45187118020077 0.144740429944725 no 475 0.0732687136644139 80 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2558 carylophyllene oxide 100 µM 1.43828464098697 0.147186991851358 no 476 0.0751766539810044 96 6708694 An oxygenated terpenoid and antifungal agent. SGTC_95 0471-0001 561.058 µM 1.43816462409041 0.147208726394335 no 477 0.0751936749994278 106 4015405 SGTC_2923 7992654 58.14 µM 1.43784371145499 0.147266852857183 no 478 0.0752392018557372 102 2985126 SGTC_217 ketoconazole 989 nM 1.43686399617423 0.147444402495796 no 479 0.0753783209637663 105 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_724 3910-0327 137 µM 1.4310915555007 0.148493428682707 no 480 0.0762019885767859 121 2885483 SGTC_583 1488-1091 88.9 µM 1.42839712035206 0.148984793022101 no 481 0.0765887937801304 128 4303273 SGTC_2773 thioridazine 9.09 µM 1.42794784257976 0.14906683004891 no 482 0.0766534357895546 94 5452 An antipsychotic. SGTC_548 1436-0017 110 µM 1.42629032796872 0.149369749146098 no 483 0.0768922776546973 101 9677137 SGTC_1391 3442-0225 151 µM 1.42517553551094 0.149573714029144 no 484 0.0770532331425821 94 5227075 SGTC_582 0987-0078 156 µM 1.42503121009074 0.14960013370803 no 485 0.0770740897806165 106 1625765 SGTC_2722 naftopidil 47.16 µM 1.42415884821877 0.149759891345649 no 486 0.0772002471800889 95 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.42195696543999 0.150163633192528 no 487 0.0775193721727836 79 6708561 SGTC_786 4544-0069 423 µM 1.41857053635625 0.15078599068688 no 488 0.0780121304132554 121 748821 YLR208W SEC13 SGTC_1744 st037937 38.9 µM 1.41806582328341 0.150878893623391 no 489 0.0780857740943727 101 1016152 SGTC_3174 9107204 49.47 µM 1.4179631517317 0.15089779712035 no 490 0.078100761556579 91 3938802 SGTC_3177 9107506 49.47 µM 1.41713483657935 0.15105036102804 no 491 0.078221754547904 89 8897194 SGTC_570 0987-0065 62.6 µM 1.41578421240372 0.151299346912951 no 492 0.0784193466603842 91 3104428 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.41365693744401 0.151692060666778 no 493 0.0787313274396668 111 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3164 9100705 49.47 µM 1.41247078434721 0.151911328937516 no 494 0.0789056935978706 75 17174235 SGTC_3346 9158254 43.5805 µM 1.41117211079825 0.152151638711575 no 495 0.0790969357260981 124 17639500 SGTC_2390 9097792 176.6 µM 1.41064131588327 0.152249930950246 no 496 0.0791752013381106 102 4497149 SGTC_835 0312-0010 67.2 µM 1.40950821584109 0.152459898660846 no 497 0.0793424729069914 114 1626196 SGTC_2870 9038528 12.99 µM 1.40540502744096 0.153221842138549 no 498 0.0799504363132423 94 6463316 SGTC_207 4185-0010 4.486 µM 1.40185033893664 0.153883968154936 no 499 0.0804799713633731 122 3761753 SGTC_956 1185-0240 191 µM 1.40076247082073 0.154086981444604 no 500 0.0806425573316153 100 1416193 SGTC_521 r062-0005 13.8 µM 1.40028148650911 0.154176797138506 no 501 0.0807145212761401 98 2832033 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.40024849642874 0.154182958747373 no 502 0.0807194589649287 117 688662 SGTC_802 4112-3352 742 µM 1.3962616555216 0.154928786474014 no 503 0.0813178580599307 103 704594 SGTC_3055 9094636 49.47 µM 1.39535414249636 0.155098889450581 no 504 0.0814545363029943 132 25236176 SGTC_3088 9117578 49.47 µM 1.39339022757169 0.155467424939638 no 505 0.0817509096283496 112 678341 SGTC_3190 9110366 49.47 µM 1.39270787629208 0.15559560567037 no 506 0.0818540729368956 99 17123768 SGTC_90 0870-0863 4.608 µM 1.38971836538525 0.156158011385251 no 507 0.0823072078570144 119 1738164 SGTC_2110 5483698 200 µM 1.38629463466393 0.156803748620917 no 508 0.0828284772551036 98 2848765 YHR062C RPP1 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.38383447805204 0.157268833111974 no 509 0.0832045716176162 99 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2339 9000433 200 µM 1.38314184128381 0.157399937256291 no 510 0.0833106891694164 98 2988954 SGTC_244 nsc-207895 1.295 µM 1.3820350560364 0.157609581602016 no 511 0.0834804687520312 60 42640 SGTC_496 calpeptin 138 µM 1.38152333343235 0.157706572741742 no 512 0.0835590542591377 103 73364 A calpain inhibitor. SGTC_1063 disulfiram 1.84 µM 1.3815052270727 0.157710005312217 no 513 0.0835618358801391 115 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_745 0469-0705 296 µM 1.37991317023315 0.158012016405319 no 514 0.0838066905097442 155 3486736 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.37967413914086 0.158057393050747 no 515 0.0838434994162652 145 2346 DNA damaging agent; causes G2/M arrest. SGTC_1160 4092-0570 10.5 µM 1.37935362465972 0.158118251579831 no 516 0.0838928751781564 118 4994975 SGTC_2168 5727979 200 µM 1.37862462014395 0.158256730495717 no 517 0.0840052607891689 113 695210 SGTC_1481 3346-2004 36 µM 1.37659712523056 0.158642284016901 no 518 0.0843184200994161 130 2770522 SGTC_365 0121-0052 13.6 µM 1.37430010420023 0.159079834831278 no 519 0.0846742669969412 102 3101739 SGTC_1478 0453-0656 35.7 µM 1.37317251211862 0.159294914606138 no 520 0.0848493614444681 122 5258496 SGTC_87 0100-0052 35.5 µM 1.37313121587089 0.159302795170297 no 521 0.0848557791463275 135 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2643 anethole 100 µM 1.37011038872879 0.159879952074296 no 522 0.0853262226855789 122 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1665 st014639 11.4 µM 1.36966576000702 0.159965017825911 no 523 0.0853956308432781 119 981133 YIL048W NEO1 SGTC_2774 tamoxifen 10.92 µM 1.36887640608684 0.160116108831475 no 524 0.0855189560259541 103 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1966 st070145 16.1 µM 1.36621860978974 0.160625525959497 no 525 0.0859351790484428 129 3748532 SGTC_2403 6032726 181.2 µM 1.36454851266751 0.16094617277374 no 526 0.0861974983561316 98 2881040 SGTC_2956 9076196 2.52 µM 1.36396797359865 0.161057729952159 no 527 0.0862888227835435 120 16423868 SGTC_633 0437-0093 97.7 µM 1.36334293982908 0.161177893689201 no 528 0.0863872275318508 112 2831118 SGTC_2860 9025725 38.96 µM 1.36020245427789 0.161782542079079 no 529 0.0868829330712083 117 40546248 SGTC_209 4077-0173 175.592 µM 1.35975044916185 0.161869689691581 no 530 0.086954453776898 103 15993494 SGTC_3121 9125696 49.47 µM 1.35899767800598 0.162014893551083 no 531 0.08707366225012 91 1235365 SGTC_1200 1643-0193 18.4 µM 1.35363074501694 0.163052592155457 no 532 0.0879271065170151 125 5403974 SGTC_2231 micatex 6.853 µM 1.35012486002446 0.16373278406353 no 533 0.0884879676589418 116 20737 An antifungal of unknown mechanism. SGTC_1258 0671-0043 57.1 µM 1.3487174151904 0.164006365920025 no 534 0.0887138747913355 127 4298767 SGTC_449 xestospongin c 11.1929 µM 1.34187647238395 0.165340342918408 no 535 0.0898180257448346 108 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2283 7944793 200 µM 1.34050244946356 0.165609120324629 no 536 0.0900410242568219 120 2970533 SGTC_3250 9135583 49.47 µM 1.34027834584784 0.165652984799215 no 537 0.0900774343774228 112 7699353 SGTC_532 1548-0774 215 µM 1.33840098261378 0.166020741803059 no 538 0.0903828793841077 132 5932993 SGTC_1025 k007-0731 70 µM 1.33720315583649 0.166255659763379 no 539 0.0905781660383257 101 6256118 SGTC_2058 5236698 133 µM 1.33694757643191 0.166305811810753 no 540 0.090619874721806 112 766665 SGTC_2988 9073640 71.4286 µM 1.33558024991805 0.166574286623321 no 541 0.0908432545454648 126 9102229 SGTC_303 1348-1668 34.2 µM 1.33542333158995 0.166605115450476 no 542 0.0908689163688949 120 5380509 SGTC_194 1486-1323 56.904 µM 1.33376358924354 0.166931420777513 no 543 0.0911406736612581 146 5178754 SGTC_787 4152-0075 138 µM 1.33182762957804 0.16731255087413 no 544 0.0914584182733475 116 9566539 SGTC_473 2-arachidonoylglycerol 10 µM 1.32960935678505 0.167749948523504 no 545 0.0918235068214364 119 5282280 An endocannabinoid. SGTC_2407 paclitaxel 400 µM 1.32752493269731 0.168161624354883 no 546 0.0921675489633481 121 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.32634395775653 0.16839515630307 no 547 0.0923628963800306 108 4620898 SGTC_1689 st020265 53.493 µM 1.32556814682755 0.168548682525997 no 548 0.0924913914582453 117 5758320 YPR016C TIF6 SGTC_379 3970-0972 5.9 µM 1.32379731949129 0.168899450820752 no 549 0.0927851833106644 115 2898042 YBL034C STU1 SGTC_1838 st055369 84.5 µM 1.32307230608443 0.169043197840157 no 550 0.0929056666858685 109 676036 SGTC_2911 7942208 15.64 µM 1.32205201925546 0.169245621202958 no 551 0.0930754147282225 94 1243384 SGTC_1147 3809-1045 12.3 µM 1.31722634804874 0.170205134539445 no 552 0.0938813823038937 129 325925 SGTC_2236 dapsone 200 µM 1.31706010687529 0.170238251123389 no 553 0.0939092388479246 90 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1625 st003711 30.1 µM 1.31232215450795 0.171183824642893 no 554 0.0947057300590254 117 24207034 YER133W GLC7 SGTC_2634 4'-methoxyflavone 100 µM 1.31213425261481 0.171221394140414 no 555 0.0947374203393777 114 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2729 fluphenazine 10.66 µM 1.31072677546061 0.17150297569709 no 556 0.0949750445925797 139 3372 An atypical antipsychotic. SGTC_1456 k015-0012 13 µM 1.30663708865428 0.172322841374264 no 557 0.0956679970788271 150 2989616 SGTC_529 4076-0302 30.3 µM 1.30379147171246 0.172894779197315 no 558 0.096152345593822 115 5816522 SGTC_3229 9132204 49.47 µM 1.30305844505056 0.173042305233768 no 559 0.0962774045463398 96 17682924 SGTC_338 4055-0136 114 µM 1.30216079383702 0.173223072145957 no 560 0.0964307122702795 105 2900563 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.30061802461598 0.173534032246714 no 561 0.0966946171184108 125 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1911 st060208 74.3 µM 1.29861763086646 0.173937759596274 no 562 0.0970375921490362 136 688783 SGTC_3273 9137859 49.47 µM 1.29780511681134 0.174101914810016 no 563 0.097177155456147 143 2377234 SGTC_2033 5192550 145 µM 1.29754124383925 0.174155247217689 no 564 0.0972225118632737 116 182073 SGTC_946 3434-1334 87.4 µM 1.29594822444004 0.174477439186925 no 565 0.0974966616362427 139 4047976 SGTC_1814 st052110 31.539 µM 1.29516556937253 0.174635871645311 no 566 0.0976315597417823 123 674163 SGTC_3114 9122766 49.47 µM 1.29472080910714 0.174725944925785 no 567 0.0977082793978985 106 17176985 SGTC_1252 0493-0875 34.8 µM 1.29265219448837 0.175145270263714 no 568 0.0980656894043854 112 3960963 SGTC_1963 st076565 50.3 µM 1.29251957744126 0.175172174593853 no 569 0.0980886352743165 143 4914280 SGTC_1726 st035556 14.5795 µM 1.29078593308893 0.175524124154727 no 570 0.0983889584551444 104 5919439 SGTC_2903 5923464 63.88 µM 1.28322189412935 0.177064948776391 no 571 0.0997071737813408 124 2876576 SGTC_2241 6772625 37.8075 µM 1.28183448566237 0.177348494059252 no 572 0.0999503569921665 135 2285411 SGTC_74 000s-0487 160.283 µM 1.28145195315265 0.177426722790487 no 573 0.100017482924496 103 677548 SGTC_2502 avocadyne acetate 18.59 µM 1.27804777341307 0.178123844193281 no 574 0.100616291042283 116 3952079 SGTC_688 0527-0193 473 µM 1.27752591620281 0.178230864611146 no 575 0.100708318397346 128 4007154 SGTC_545 4218-0007 221 µM 1.27625756230599 0.178491142521109 no 576 0.100932243234395 139 2840508 SGTC_1470 k295-0292 231 µM 1.27577620960556 0.178589983173425 no 577 0.101017319848469 141 5045612 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.27432381158149 0.178888426507054 no 578 0.101274340525265 113 641818 YHR062C RPP1 SGTC_574 1315-0397 40 µM 1.2728368927699 0.179194288250636 no 579 0.101537963356892 150 6794277 SGTC_3334 9142812 21.919 µM 1.27251319766465 0.17926091645969 no 580 0.101595418965401 126 45283678 SGTC_2703 st077852 53.4 µM 1.27212864619247 0.179340091365483 no 581 0.101663707293085 144 6281836 SGTC_1736 st036774 51 µM 1.27063500883808 0.179647823337866 no 582 0.10192926316263 139 1272247 SGTC_906 1165-0455 526 µM 1.26882512085572 0.180021156317585 no 583 0.102251721701302 133 3252859 SGTC_2611 pyromycin 23.93 µM 1.26827120111775 0.180135512892678 no 584 0.102350558901602 128 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1199 1638-0010 4.46 µM 1.26753471643652 0.180287630554668 no 585 0.102482079168465 137 3111136 SGTC_861 0443-0273 110 µM 1.26698558433767 0.180401103811653 no 586 0.102580222243154 140 6149169 SGTC_2912 7964298 10.93 µM 1.26671815354538 0.180456382223907 no 587 0.102628043270822 161 2975850 SGTC_3046 9092212 49.47 µM 1.26602055027487 0.180600628042713 no 588 0.10275286248104 123 25236637 SGTC_1240 0356-0016 42.1 µM 1.26462509634197 0.180889387752363 no 589 0.103002876160256 122 4305613 SGTC_3289 9119912 71.43 µM 1.26446587677631 0.180922353259424 no 590 0.103031430473152 129 17014829 SGTC_134 0269-0018 6.916 µM 1.26376571318577 0.181067362833213 no 591 0.103157065503094 134 4378915 SGTC_3031 9088762 49.47 µM 1.26187814795944 0.181458655575341 no 592 0.10349631810845 130 205253 SGTC_3238 9133470 49.47 µM 1.26060930679521 0.181721983943985 no 593 0.103724821928991 108 3534688 SGTC_2418 pentamidine 31.67 µM 1.26011228989715 0.181825197252421 no 594 0.103814428694719 144 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_253 dyclonine 31.25 µM 1.25858642906756 0.182142295077815 no 595 0.104089875665697 125 3180 An oral anasthetic. SGTC_585 0kpi-0023 191 µM 1.25446108258654 0.183001336144906 no 596 0.104837231328532 94 64601 SGTC_2970 9090938 41.86 µM 1.2543240444051 0.183029915590588 no 597 0.104862123931735 141 17217104 SGTC_1022 4477-0945 21.3 µM 1.25190922923481 0.183533984443277 no 598 0.105301470689255 120 4648966 SGTC_1426 4048-4480 71.7 µM 1.25137713118669 0.183645170883099 no 599 0.105398458365513 127 14224343 SGTC_469 w7 172 µM 1.2510690581449 0.183709564561823 no 600 0.105454641620372 107 45115570 A P450 inhibitor. SGTC_1307 1187-1599 12.2 µM 1.2506982113614 0.183787097915717 no 601 0.105522301645247 148 1538471 SGTC_950 1165-0508 94.1 µM 1.25049904606523 0.183828746039935 no 602 0.105558651787472 125 6148369 SGTC_2370 9071495 200 µM 1.24960951697148 0.184014830207952 no 603 0.105721112442008 141 21791103 SGTC_2809 7964133 12.99 µM 1.2488612486227 0.184171454261748 no 604 0.105857913621579 137 1253665 SGTC_2439 5492030 7.2 µM 1.24876374049581 0.184191870318785 no 605 0.105875749835331 136 5722370 SGTC_1052 3253-3998 198 µM 1.2485094620367 0.184245117260929 no 606 0.105922272739287 112 5450317 SGTC_2728 chlorpromazine 9.18 µM 1.24769185001812 0.184416393449332 no 607 0.106071963530968 129 2726 A thorazine and dopamine antagonist. SGTC_1722 st034304 3.6505 µM 1.24762248666475 0.184430928480588 no 608 0.106084669805648 137 4036148 YLR033W RSC58 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.2467725965659 0.184609080078312 no 609 0.106240445587147 115 6857784 SGTC_2623 humulene 100 µM 1.24657439269612 0.184650642404755 no 610 0.10627679798665 115 6187145 An anti-inflammatory. SGTC_1484 3473-2379 286 µM 1.24302502458891 0.185395911252663 no 611 0.106929306030324 114 671917 SGTC_1801 st050089 28.441 µM 1.24053389649413 0.185920092629647 no 612 0.107388992389755 139 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2170 morpholine 200 µM 1.24050746990062 0.185925658216123 no 613 0.107393876497012 121 121171 Reacts with secondary amines. SGTC_2873 9040596 71.43 µM 1.23850093625626 0.186348546965209 no 614 0.107765187568645 153 6463863 SGTC_2015 5119600 184 µM 1.23719524428038 0.186624048999324 no 615 0.108007303335271 155 2828786 SGTC_1682 st012968 530 nM 1.23594860270861 0.186887326560182 no 616 0.10823883459879 116 24207270 SGTC_2529 gangaleoidin 93.61 µM 1.23363281085197 0.187377007056525 no 617 0.10866988046476 125 4565183 SGTC_57 miconazole 162.5 nM 1.23329359296458 0.187448802143011 no 618 0.108733123712743 153 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_703 3875-0075 71.8 µM 1.23183541180091 0.187757618145538 no 619 0.109005286139781 154 2850814 SGTC_1363 1636-0063 10.4 µM 1.23159338294726 0.187808905804509 no 620 0.109050506988652 154 6072185 SGTC_2682 pyrogallin 40.03 µM 1.23141704704505 0.187846278101191 no 621 0.109083462207378 129 822798 An ATP competetive kinase inhibitor. SGTC_1857 st056007 79.3 µM 1.22931504503431 0.188292126011414 no 622 0.109476854284313 121 619834 SGTC_2563 tomatine 8.54 µM 1.22842398324457 0.188481322720545 no 623 0.109643924656852 136 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1507 4075-3230 155 µM 1.22689669050107 0.18880588117412 no 624 0.109930711307875 121 659771 SGTC_3098 9119039 49.47 µM 1.22230431165746 0.189783860973418 no 625 0.110796284682019 139 17161528 SGTC_3322 9139058 2.11 µM 1.21956444658893 0.190368815716195 no 626 0.11131501555231 131 4908926 YPR165W RHO1 SGTC_1704 st028805 70.8 µM 1.21677586232922 0.1909653075857 no 627 0.111844753090655 146 2876101 SGTC_677 0929-0063 136 µM 1.2155519064642 0.191227479378718 no 628 0.112077832126172 125 1539583 SGTC_2838 9002687 71.43 µM 1.21374906320573 0.191614050698464 no 629 0.112421781307136 161 6457060 SGTC_1759 st043059 70 µM 1.21145265376848 0.192107146624367 no 630 0.112860984964295 152 669426 SGTC_2249 haloperidol 116.36 µM 1.21120363918556 0.192160662836733 no 631 0.112908684181619 174 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_66 0109-0187 42.4 µM 1.21097040613508 0.192210795680055 no 632 0.112953373466004 116 759417 SGTC_2517 totarol 10 µM 1.210287782589 0.19235756982234 no 633 0.1130842420448 123 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1763 st044482 94.5 µM 1.21012118964458 0.192393400167043 no 634 0.113116196684783 154 88505 SGTC_2333 9017922 200 µM 1.20981866145607 0.192458477517772 no 635 0.113174241902145 126 3163164 SGTC_98 0074-0023 107.663 µM 1.20707857578886 0.193048514756072 no 636 0.113700942384967 117 3563821 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.20693368328121 0.193079745947939 no 637 0.113728842246051 177 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1706 st031321 9.9705 µM 1.2020796517398 0.194127801452666 no 638 0.114666334633396 142 6103185 SGTC_2674 ligustilide 100 µM 1.20163753339182 0.194223433077732 no 639 0.114751996437571 140 5319022 A signalling regulator. SGTC_396 dithiazanine 1.25 µM 1.20040155168614 0.194490932089323 no 640 0.114991713269757 118 10578 An antihelmenthic. SGTC_1261 0712-0010 12.7 µM 1.19907996002236 0.19477720729606 no 641 0.115248427790489 144 2840123 SGTC_2189 6047310 154.431 µM 1.19858879631373 0.194883665509584 no 642 0.115343938370717 120 711535 SGTC_1612 st002233 45.4 µM 1.19822748585201 0.194962001018331 no 643 0.115414233887657 136 1035021 SGTC_1845 st056753 3.01 µM 1.19723425801071 0.195177440796442 no 644 0.115607630283876 124 5375839 SGTC_1743 st037606 46.3785 µM 1.19656572257211 0.1953225333963 no 645 0.1157379337505 120 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1952 st077036 64.1 µM 1.1934840206443 0.195992203632128 no 646 0.116339933308824 141 2937007 SGTC_1822 st052468 42 µM 1.19252080139056 0.196201801681318 no 647 0.116528549680075 135 2873678 SGTC_620 0109-0052 432 µM 1.1895146150479 0.196856826156952 no 648 0.117118611666061 151 493037 SGTC_728 3030-5151 22.5 µM 1.18837304846255 0.197105911048693 no 649 0.11734323491901 131 3125388 SGTC_2359 9039622 200 µM 1.18416691614636 0.198025315651589 no 650 0.118173497776322 142 6463596 SGTC_1523 st012844 44.7 µM 1.18408821221808 0.198042543931407 no 651 0.118189072907572 115 4274103 SGTC_680 0417-1641 114 µM 1.18306945184876 0.198265632123933 no 652 0.118390811729748 139 2835990 SGTC_2261 9010538 184.68 µM 1.1815582642106 0.198596831300926 no 653 0.118690511021526 142 6457250 SGTC_25 0118-0223 35.662 µM 1.18136547077912 0.198639108828228 no 654 0.118728784405061 142 5333628 SGTC_1179 1021-1431 9.29 µM 1.18127898235338 0.198658076573878 no 655 0.118745956934201 166 2840958 SGTC_1859 st055998 20 µM 1.18040958978536 0.198848803413001 no 656 0.11891867483552 138 676301 SGTC_3016 9080866 49.47 µM 1.18019936883849 0.198894938129298 no 657 0.118960465009562 145 17066299 SGTC_868 0527-0199 213 µM 1.17862544378354 0.199240553857954 no 658 0.11927367770833 145 2849450 SGTC_170 4197-0004 226 µM 1.1736390670532 0.200337890263169 no 659 0.120269813058024 158 218692 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.17091254041016 0.200939440934442 no 660 0.120816966943372 139 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2334 9017922 200 µM 1.17032968304392 0.201068176588991 no 661 0.120934160521326 135 3163164 SGTC_1610 st001799 48.1 µM 1.16929166806797 0.201297565326503 no 662 0.121143069461973 130 621897 SGTC_1843 st055809 45.5 µM 1.16924141432444 0.201308674775193 no 663 0.121153189874097 137 16413835 SGTC_3259 9138485 49.47 µM 1.1683897944304 0.201496995789271 no 664 0.121324784833561 113 17646153 SGTC_1364 1653-0028 37.6 µM 1.16789671823773 0.201606079300853 no 665 0.121424214035038 137 5718652 SGTC_2942 9052777 62.25 µM 1.16736589329552 0.201723553523324 no 666 0.121531319320737 182 6469503 SGTC_2441 5730946 39.09 µM 1.1643928114852 0.202382268908759 no 667 0.122132429718229 138 1774275 SGTC_2204 7233102 200 µM 1.1639099474274 0.202489373460253 no 668 0.122230253959619 128 2172480 SGTC_225 nsc-122657 1.016 µM 1.15853895929341 0.203683000926994 no 669 0.123322081212766 133 275685 SGTC_2099 5377090 177.372 µM 1.15704664868721 0.204015389491309 no 670 0.123626651031338 163 2243829 SGTC_982 1491-0518 27.5 µM 1.15499125576459 0.204473724433502 no 671 0.124047003650695 130 3091256 SGTC_1038 k292-0204 154 µM 1.15023141690475 0.205537477625482 no 672 0.125024284844614 145 4454212 SGTC_139 0099-0334 718.624 µM 1.14991423301675 0.205608480083685 no 673 0.125089599040713 152 97690 SGTC_1452 4194-0072 190 µM 1.14873742916427 0.205872037953556 no 674 0.125332133547256 155 1343545 SGTC_815 1582-0027 36.9 µM 1.14745545475405 0.206159377873915 no 675 0.125596716664553 164 3128206 SGTC_345 1362-0200 395 µM 1.14711838825356 0.206234966937566 no 676 0.125666347539175 149 1419823 SGTC_1466 k213-0079 57.5 µM 1.1463141769203 0.206415382209841 no 677 0.12583258952052 179 3657981 SGTC_3131 9127911 49.47 µM 1.14425557416348 0.206877631178484 no 678 0.126258830794599 144 45595681 SGTC_43 0570-0105 72.5 µM 1.14345219656911 0.207058191686397 no 679 0.126425445743096 143 1114046 YDL195W SEC31 SGTC_1662 st014054 52 µM 1.14142158402126 0.207514990841979 no 680 0.126847263459598 139 2838777 SGTC_615 k087-0205 167 µM 1.13960241306625 0.207924730230208 no 681 0.127225989788122 167 9642773 SGTC_2184 6075246 200 µM 1.13934755676094 0.207982170693239 no 682 0.127279110118505 150 2267320 SGTC_675 1309-0189 238 µM 1.13685771094132 0.208543834075869 no 683 0.12779888656481 141 4246530 SGTC_2507 purpurin 79.67 µM 1.13666114704935 0.208588213326867 no 684 0.127839983682754 151 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2019 4016004 108 µM 1.13611080384739 0.20871249678372 no 685 0.127955097000517 170 45595336 SGTC_1368 1852-0141 284 µM 1.13609420644557 0.208716245636273 no 686 0.127958569737997 154 2838987 SGTC_13 0199-0087 65 µM 1.13581872644092 0.208778474057391 no 687 0.128016219030159 166 4589825 SGTC_2706 st078239 82.5 µM 1.13539644060951 0.208873885798336 no 688 0.128104625184586 162 15434492 SGTC_268 camptothecin 39.6153 µM 1.1344758468243 0.209081974827779 no 689 0.128297499803018 198 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2388 9080168 200 µM 1.13434957230325 0.209110527165305 no 690 0.128323971434371 158 15943073 SGTC_882 0843-0131 351 µM 1.13317413452942 0.209376419312297 no 691 0.128570566959369 178 5425421 SGTC_1526 st051518 75 µM 1.13247790780642 0.209534004385646 no 692 0.128716783610568 147 673993 SGTC_3235 9132602 49.47 µM 1.13225910318843 0.209583543378792 no 693 0.128762759238457 172 4912240 SGTC_2661 dactinomycin 12.96 µM 1.13127770134944 0.209805824783756 no 694 0.128969113336851 140 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1787 fluconazole 80 µM 1.13009439703369 0.210074020048292 no 695 0.129218225209602 150 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1660 st012960 28.1 µM 1.12980242574551 0.210140226145337 no 696 0.1292797429276 144 24207266 SGTC_2265 7929201 200 µM 1.12923773091556 0.210268308577516 no 697 0.129398780494084 198 1265108 SGTC_2040 5100729 123 µM 1.12575534160903 0.211059186437963 no 698 0.130134545883646 144 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2864 9034755 47.6 µM 1.1256834196912 0.2110755388244 no 699 0.130149772126774 139 4930451 SGTC_2964 9083345 53.42 µM 1.12435153979577 0.211378493277138 no 700 0.130431960827878 163 17741579 SGTC_1749 st037932 54.2 µM 1.12132303890056 0.212068314785959 no 701 0.131075191111363 163 594497 SGTC_1851 st056236 18.9 µM 1.12046884187163 0.212263118593772 no 702 0.131257011532008 157 5393171 SGTC_3192 9110362 49.47 µM 1.11991461783468 0.212389568020865 no 703 0.131375074217698 151 16649480 SGTC_2251 lansoprazole 556 µM 1.11987252595845 0.212399173324487 no 704 0.131384043766903 140 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1262 0737-0114 49.6 µM 1.1192931075885 0.212531421528814 no 705 0.131507557632092 176 765919 SGTC_987 1497-1013 404 µM 1.11770504698483 0.212894131766145 no 706 0.131846493261239 159 1676435 SGTC_750 4073-0104 132 µM 1.11710531296182 0.213031203880293 no 707 0.131974649555037 122 22330957 SGTC_3035 9091303 49.47 µM 1.11480543188768 0.213557329938852 no 708 0.132466904133188 162 25237002 SGTC_903 1134-0042 114 µM 1.11410134157348 0.213718550503402 no 709 0.132617856589947 155 701009 SGTC_512 prima-1 270 µM 1.1125570152904 0.214072414043525 no 710 0.132949365137021 134 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2832 7992762 51.95 µM 1.11242709701294 0.214102198774677 no 711 0.132977279679737 151 2985177 SGTC_2850 9015429 58.44 µM 1.11240131788391 0.214108109118422 no 712 0.132982819122959 169 6457570 SGTC_1774 st048371 48.465 µM 1.11099755922548 0.21443009016823 no 713 0.133284699953738 195 4242727 SGTC_122 0236-0016 402.397 µM 1.11012269882613 0.214630899814252 no 714 0.133473078579469 179 6808838 SGTC_3213 9129884 49.47 µM 1.10928522476773 0.214823230401934 no 715 0.133653578496898 147 17190742 SGTC_3005 9076496 71.4286 µM 1.10777653579051 0.215169961777818 no 716 0.133979168020489 160 21368410 SGTC_2536 dehydroabietamide 32.04 µM 1.10619672551587 0.215533386405191 no 717 0.134320689928578 136 3983547 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.10546498262862 0.215701839450071 no 718 0.134479079832295 143 16486 A toxic proline analog. SGTC_2011 4012611 177 µM 1.10360379237758 0.216130644075593 no 719 0.134882522695178 140 2049887 SGTC_528 3492-0019 172 µM 1.10074598715747 0.216790021561895 no 720 0.135503612695646 178 2869262 SGTC_1154 4088-0362 150 µM 1.10072049050964 0.216795909598815 no 721 0.135509162716143 168 6618304 SGTC_305 1682-2595 20.8 µM 1.10063672763777 0.216815253925195 no 722 0.135527397019494 167 226033 SGTC_1436 4092-1007 8.32 µM 1.0997217721496 0.217026620130494 no 723 0.13572668276472 133 2881121 SGTC_2508 celastrol 40.54 µM 1.09960035645316 0.217054677627294 no 724 0.135753143300423 128 122724 Celastrol is a natural product and antioxidant. SGTC_1290 0986-0249 10.2 µM 1.09934194554182 0.217114399810533 no 725 0.135809471430643 156 53329 SGTC_2680 butyl paraben 22.24 µM 1.09896890908416 0.217200630218405 no 726 0.13589081374052 183 7184 An antifungal and steroid mimetic. SGTC_1981 st071826 47 µM 1.09642329800594 0.21778959678813 no 727 0.13644678642463 157 11838600 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.09622848825952 0.217834706957367 no 728 0.136489397732374 178 279621 SGTC_636 0kpi-0074 126 µM 1.09585815200193 0.217920476925789 no 729 0.136570427564552 158 616434 SGTC_2589 lobaric acid 100 µM 1.09555639813352 0.217990377592038 no 730 0.136636475840675 135 73157 A novel microtubule depolymerizer. SGTC_662 k832-1615 104 µM 1.09513633318555 0.218087706297934 no 731 0.136728456559328 158 5878478 SGTC_3341 9147222 25.867 µM 1.09493717450371 0.218133859953839 no 732 0.136772080697465 172 1939759 SGTC_3159 9100096 49.47 µM 1.09415464369264 0.218315260597485 no 733 0.136943580033503 135 25236875 SGTC_2120 5538279 151.968 µM 1.09378680317368 0.218400560749503 no 734 0.137024246662287 135 2058197 SGTC_2686 alizarin 95.37 µM 1.09211464779044 0.218788566095989 no 735 0.137391355941472 134 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2470 5664817 21.68 µM 1.09111835130206 0.219019934236799 no 736 0.137610404421667 151 2859561 SGTC_1812 st052057 4.327 µM 1.09075717598422 0.219103844070254 no 737 0.137689872256873 155 3645418 SGTC_3327 9140648 26.9345 µM 1.08818062150152 0.219702976538815 no 738 0.138257688920548 208 8029710 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.08695902374127 0.219987366026413 no 739 0.13852745962059 152 5379071 SGTC_2232 chlorophetanol 41.5365 µM 1.08652778251995 0.220087809941714 no 740 0.138622778077907 163 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3082 9117008 49.47 µM 1.08599229064114 0.220212572337056 no 741 0.138741201527824 165 41448529 SGTC_2133 5320837 200 µM 1.08544806646908 0.220339410783482 no 742 0.138861626697189 125 2841355 SGTC_983 1491-0821 12.2 µM 1.08397520772628 0.220682889436166 no 743 0.13918789574113 148 46495113 SGTC_991 3996-0057 64.7 µM 1.08394342395075 0.220690304964122 no 744 0.139194942258634 152 715343 SGTC_419 nsc-638432 893 µM 1.08280780932415 0.220955350823401 no 745 0.139446869272325 159 368090 SGTC_1190 1486-1332 13 µM 1.08137065040352 0.221291036428941 no 746 0.139766135844322 169 4150046 SGTC_565 1418-0001 44.5 µM 1.07777615299898 0.222131900058362 no 747 0.140566832082909 169 2862145 SGTC_2266 7929956 200 µM 1.07646570992553 0.22243890606942 no 748 0.140859514263019 178 2967153 SGTC_1046 2001-0062 216 µM 1.07638609629443 0.222457565466296 no 749 0.140877308958881 181 739778 SGTC_429 1112-0049 25.5 µM 1.07424620556122 0.222959435409946 no 750 0.141356174155854 147 2836170 SGTC_411 enrofloxacin 100 µM 1.07421590230737 0.222966547079431 no 751 0.141362963337309 151 71188 A bacterial gyrase inhibitor. SGTC_2673 kobusone 100 µM 1.07341756342278 0.223153950466672 no 752 0.141541903856874 190 6710676 An epoxy ketone and protein crosslinker. SGTC_2085 5307070 144.047 µM 1.07269819806286 0.223322892259737 no 753 0.141703274563054 193 2840351 SGTC_3176 9106582 49.47 µM 1.07268245303911 0.22332659076694 no 754 0.141706807938258 113 17018027 SGTC_369 0957-0393 4.5 µM 1.0705213396154 0.223834567098563 no 755 0.142192354421102 162 6997992 SGTC_3147 9097027 49.47 µM 1.06895393021241 0.22420340198957 no 756 0.142545214517715 188 25236841 SGTC_1188 1403-0014 4.57 µM 1.06766937400657 0.224505934436857 no 757 0.142834838988659 161 9614867 SGTC_1819 st053448 58.6 µM 1.06645807462276 0.224791425870259 no 758 0.14310831062568 189 2857616 SGTC_616 4092-0450 108 µM 1.06218034500375 0.225801290449626 no 759 0.144076910463782 176 787165 SGTC_2383 9036125 200 µM 1.06125268855134 0.22602062492342 no 760 0.144287540234779 170 79580 SGTC_2947 9072639 7.68 µM 1.06032413910437 0.226240291095091 no 761 0.144498580527475 174 16488146 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.05907135335944 0.226536852635193 no 762 0.144783642545801 176 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_535 2293-4129 48.2 µM 1.05461192128887 0.227594275989832 no 763 0.145801424657913 198 396118 YIL048W NEO1 SGTC_299 1273-0059 1.44 µM 1.04955971795696 0.228795608342477 no 764 0.146960292749975 176 2848077 SGTC_1348 1493-0373 93.8 µM 1.04777098586563 0.229221791656029 no 765 0.147372066599169 184 3010129 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.04750041208675 0.229286297304614 no 766 0.147434421108932 177 5282362 SGTC_1465 k213-0056 144 µM 1.04716630454984 0.229365963643774 no 767 0.147511441545261 186 24048857 YMR208W ERG12 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.04221867687019 0.230547516264181 no 768 0.148655152918483 160 61125 An anti-inflammatory. SGTC_937 3122-0005 46.7 µM 1.0420794289607 0.230580819471209 no 769 0.148687427501232 179 759535 SGTC_1958 st076513 41.9 µM 1.03669582032234 0.231870448748199 no 770 0.149938820270707 178 732122 YGL099W LSG1 SGTC_2007 4011539 71.82 µM 1.03526966063531 0.232212753406775 no 771 0.150271497231327 152 45595301 SGTC_1680 diphenhydramine 100 µM 1.03380078514724 0.232565604425954 no 772 0.150614652259535 183 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_559 1550-0661 158 µM 1.03113863878338 0.233205860193794 no 773 0.151237905307814 170 5830875 SGTC_2732 terfenadine 20 µM 1.0288074017099 0.233767333667823 no 774 0.151785093948898 206 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2163 5671233 125 µM 1.0281718727509 0.233920529332046 no 775 0.151934493409053 178 701023 SGTC_1259 0671-0132 43 µM 1.02719720140907 0.234155584048032 no 776 0.15216380782196 173 X1259 SGTC_129 0088-0017 176.636 µM 1.02471971003291 0.23475365173267 no 777 0.152747730100423 158 182446 SGTC_1596 piperlongumine 63 µM 1.02436777608677 0.23483867721693 no 778 0.152830798140447 160 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_125 0133-0007 11.75 µM 1.02363602329696 0.235015519514523 no 779 0.153003611862056 187 26541 SGTC_1931 st074438 57.1 µM 1.02208255280582 0.235391189649767 no 780 0.153370915054134 224 2787313 SGTC_2461 5755302 26.15 µM 1.02101604548683 0.235649291005669 no 781 0.153623418370834 190 2788904 SGTC_2784 7567673 72.73 µM 1.01836386441739 0.236291811415932 no 782 0.1542525341459 179 3471247 SGTC_2258 7960471 200 µM 1.0158954467829 0.236890678770362 no 783 0.15483958866788 166 2974708 SGTC_1707 st032323 6.317 µM 1.01551136264697 0.236983937094173 no 784 0.154931066474878 188 3132057 YMR211W DML1 SGTC_358 0075-0058 9.45 µM 1.01148091612897 0.237963773702439 no 785 0.155893155242291 179 1069125 SGTC_3298 9116858 71.43 µM 1.01091754744688 0.238100910231209 no 786 0.156027947369119 195 2506942 SGTC_2812 7970281 58.44 µM 1.01053400753038 0.238194297193548 no 787 0.156119757428269 188 2233435 SGTC_1366 1683-0113 21.9 µM 1.0094626239556 0.238455271400812 no 788 0.156376408976532 180 708623 SGTC_221 trifluoperazine 10.304 µM 1.00916504746864 0.238527784683581 no 789 0.156447743153173 224 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_859 0439-0102 54.6 µM 1.00854953830178 0.23867780993353 no 790 0.156595359224009 199 610143 SGTC_2385 9074692 200 µM 1.00848766205418 0.238692894610931 no 791 0.15661020392502 164 17046906 SGTC_1874 staurosporine 7.6 µM 1.00832263962692 0.238733127624469 no 792 0.156649798906508 196 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2210 7115885 190.385 µM 1.00676108418379 0.239114023612003 no 793 0.157024799965149 175 2927039 SGTC_1992 st073643 23.3 µM 1.00399065047018 0.239790606878085 no 794 0.157691560067896 185 3161292 SGTC_1803 st050068 52.4 µM 1.00396067212716 0.239797933766317 no 795 0.157698785110454 192 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1477 0139-0234 16 µM 1.00294265079589 0.240046816817528 no 796 0.157944266220546 185 620880 SGTC_592 k241-0073 46.5 µM 1.0025172498482 0.240150859375803 no 797 0.158046919790493 187 4230158 SGTC_1839 st053978 48 µM 0.999606423288115 0.240863434678188 no 798 0.158750506714536 172 3788398 SGTC_190 3970-0790 3.722 µM 0.995553073292136 0.241857614763394 no 799 0.159733672505501 170 2832352 SGTC_263 alizarin 107.927 µM 0.99499350092228 0.241995037829835 no 800 0.159869712630016 217 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_593 1203-0218 61.7 µM 0.994504956863131 0.242115051966891 no 801 0.159988546695538 184 3666956 SGTC_385 1494-0393 12.4 µM 0.993145229474597 0.242449247990236 no 802 0.160319592522878 191 3090647 SGTC_2927 9011802 47.9 µM 0.992296620640147 0.242657947037648 no 803 0.160526425665137 179 43912568 SGTC_2735 sertaconazole 140 nM 0.990142400796634 0.243188172602147 no 804 0.161052260583268 210 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1180 1193-0155 285 µM 0.989956825079507 0.243233878279507 no 805 0.161097611270304 185 2921347 SGTC_2215 7188065 200 µM 0.989421735792882 0.243365692088615 no 806 0.161228422155341 189 940217 SGTC_2279 7948423 32.93 µM 0.988144867896821 0.243680391418896 no 807 0.161540852222268 172 1247112 SGTC_1276 0871-0068 94.2 µM 0.987937210595413 0.243731591802765 no 808 0.161591700082961 207 3414906 SGTC_2322 7413319 38.22 µM 0.986865441409706 0.243995941591085 no 809 0.161854303974995 198 1840400 SGTC_2200 6600604 21.907 µM 0.986133263807052 0.244176620659404 no 810 0.162033861223626 217 2904777 SGTC_292 k038-0015 474 µM 0.983877640574314 0.244733692742303 no 811 0.162587839338411 189 46368540 SGTC_2475 5812728 15.03 µM 0.980254788921095 0.245629859886635 no 812 0.163480182854794 179 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1109 tnp00067 928.257 nM 0.97964373899509 0.245781185837884 no 813 0.163631003274259 173 676295 SGTC_3078 9116413 49.47 µM 0.974894809098649 0.246958958014673 no 814 0.164806220631376 215 17177322 SGTC_1474 0330-0125 5.35 µM 0.974498217137977 0.247057452414315 no 815 0.164904611968752 180 X1474 SGTC_1085 doxorubicin 7.67 µM 0.973824660470748 0.247224779689986 no 816 0.165071803214639 210 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_108 0509-0257 621.132 µM 0.973275349015687 0.247361286390431 no 817 0.165208235341838 189 536624 SGTC_433 pimozide 108 µM 0.972119381323744 0.247648681812826 no 818 0.165495580599865 172 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2212 7123476 200 µM 0.971135845568126 0.247893347746665 no 819 0.165740317889391 171 1085715 SGTC_772 k072-0172 35.3 µM 0.969321381347006 0.248345055120086 no 820 0.166192432262515 157 5861980 SGTC_1271 0832-2808 169 µM 0.969079658602461 0.248405264634608 no 821 0.166252722972486 218 3663794 SGTC_919 tnp00227 403.569 nM 0.965155698566944 0.249383751611139 no 822 0.16723341626137 182 1269246 A methoxyflavone. YNL221C POP1 SGTC_809 3998-0021 90 µM 0.964147075793062 0.249635594500986 no 823 0.167486096902549 201 715485 SGTC_2630 antimycin a 100 µM 0.963628076988409 0.249765235866385 no 824 0.167616212519456 198 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1670 st016595 4.04 µM 0.963617178206865 0.249767958669944 no 825 0.167618945596729 227 597879 SGTC_229 benomyl 22.8748 µM 0.963066956301617 0.249905439117944 no 826 0.167756961532841 174 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1402 3909-7673 35.9 µM 0.961543884123184 0.250286208852381 no 827 0.168139385686611 196 5328014 SGTC_2872 9044037 25.97 µM 0.961504396488362 0.250296084894198 no 828 0.168149307986231 186 6465195 SGTC_1125 tnp00248 1.32998 µM 0.957594669426465 0.251274948005292 no 829 0.169133594087991 210 24207736 SGTC_2900 5328528 85.29 µM 0.957202871319906 0.251373152430518 no 830 0.169232434044028 206 795359 SGTC_2465 5809242 33.21 µM 0.956969405778236 0.251431680350529 no 831 0.169291348648958 217 2731748 SGTC_3280 9140961 49.47 µM 0.956958432247214 0.251434431503065 no 832 0.169294118123477 208 4901226 SGTC_3036 9090181 49.47 µM 0.955791378079099 0.25172711217217 no 833 0.169588822585374 200 25236586 SGTC_2142 5622915 118.518 µM 0.955277582326868 0.251856021890285 no 834 0.169718670543315 179 5322196 SGTC_2924 9010168 62.78 µM 0.955168121894358 0.251883489666421 no 835 0.169746341939616 189 2993929 SGTC_22 0964-0034 14.468 µM 0.954030332091137 0.252169097918769 no 836 0.170034144448065 229 138402 SGTC_2528 xanthyletin 44.79 µM 0.95248754412749 0.252556641549909 no 837 0.170424889998061 193 65188 An natural product with antifungal activity of unknown mechanism. SGTC_678 1218-2179 85.9 µM 0.949905559841745 0.253205929461051 no 838 0.171080120762298 210 6820081 YOR116C RPO31 SGTC_969 1313-0238 134 µM 0.949398988140532 0.253333419251543 no 839 0.171208862404279 223 5212874 SGTC_1949 st076024 69.1 µM 0.947130424353009 0.253904766355513 no 840 0.17178616160996 232 2921930 SGTC_34 0469-0683 81.75 µM 0.946973699638363 0.253944263077846 no 841 0.171826090435955 168 3690923 SGTC_1578 josamycin 24.2 µM 0.945464128990905 0.254324860081763 no 842 0.17221098786853 199 5282165 A P450 substrate. SGTC_648 0375-0473 33.3 µM 0.943005622638142 0.254945344752821 no 843 0.172839013487381 211 1713139 SGTC_613 3914-0030 117 µM 0.942398590224186 0.255098671132596 no 844 0.172994304370621 168 1145395 SGTC_2365 9042475 200 µM 0.942049251057964 0.255186930306514 no 845 0.173083712515243 208 6464479 SGTC_1054 3429-0080 167 µM 0.940595080911697 0.255554492209728 no 846 0.173456201854274 196 1162877 SGTC_1826 st055655 41.6 µM 0.940589896889078 0.255555803038692 no 847 0.173457530666758 188 676168 SGTC_3230 9131665 49.47 µM 0.937456598436134 0.256348729216787 no 848 0.174261869517142 187 15943720 SGTC_3115 9123671 49.47 µM 0.937308322534256 0.256386284313009 no 849 0.1742999915829 207 3286988 SGTC_3331 9141060 1.957 µM 0.937042840655382 0.256453532323514 no 850 0.174368260803613 185 4906567 YPR165W RHO1 SGTC_3130 9127414 49.47 µM 0.936329535243822 0.256634261989357 no 851 0.174551772908638 195 1494646 SGTC_180 1486-1293 102.781 µM 0.935947093936347 0.256731188167355 no 852 0.174650214086527 197 4140536 SGTC_3051 9093778 49.47 µM 0.935390134452627 0.256872378426984 no 853 0.174793639636421 223 17217378 SGTC_2446 5162541 200 µM 0.934865387483225 0.257005439714695 no 854 0.174928838354791 197 1549321 SGTC_2786 7743617 45.45 µM 0.934093774755205 0.257201164421492 no 855 0.175127761430626 180 583674 SGTC_3278 9139605 49.47 µM 0.933489176484215 0.257354578930458 no 856 0.175283728115736 202 7958859 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.933057293845494 0.257464196615458 no 857 0.17539519369998 184 94937 An inhibitor of serotonin biosynthesis. SGTC_622 1348-1566 26.3 µM 0.930023905999536 0.25823479460932 no 858 0.176179353515824 200 7340407 SGTC_3132 9126706 49.47 µM 0.92952492061853 0.258361670630013 no 859 0.176308558224341 216 850858 SGTC_1324 1418-0026 34.4 µM 0.927220926165277 0.258947921331152 no 860 0.176905919993392 191 1372513 SGTC_577 r071-0003 38.6 µM 0.925501762874781 0.259385809767679 no 861 0.177352483566628 225 4568517 YMR134W ERG29 SGTC_3180 9109287 49.47 µM 0.925397112056176 0.259412477745912 no 862 0.177379690243251 212 18891271 SGTC_2071 5230951 39.92 µM 0.923820811877287 0.259814334725679 no 863 0.177789808810629 214 1799272 SGTC_2267 7931562 200 µM 0.922920659413937 0.260043960743658 no 864 0.17802427674938 177 934880 SGTC_876 0720-0963 56.8 µM 0.922715608713541 0.260096283151971 no 865 0.178077714748121 195 765861 SGTC_2778 tioconazole 65.09 nM 0.919928092562823 0.260808106503232 no 866 0.178805168664134 218 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2935 9038016 29.96 µM 0.919922624336671 0.260809503860094 no 867 0.178806597534833 200 6463195 SGTC_3335 9143315 29.6265 µM 0.917621800262518 0.26139780068504 no 868 0.179408450321044 197 4899691 SGTC_1122 capsaicin 818.572 nM 0.915532650247079 0.261932564375747 no 869 0.179956034994174 205 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_897 1000-0139 31.4 µM 0.912248324957529 0.262774392027181 no 870 0.18081900505592 204 6151020 SGTC_1709 st033179 39.1045 µM 0.910415657196754 0.263244736317925 no 871 0.181301671788654 198 573381 SGTC_2299 7976368 114.88 µM 0.909610320880928 0.263451557448704 no 872 0.181514026833957 193 2979718 SGTC_3169 9102970 49.47 µM 0.908331133154053 0.263780240376388 no 873 0.181851649240549 207 17027839 SGTC_3011 9081274 71.4286 µM 0.907435132961966 0.264010589042369 no 874 0.18208836881174 204 6625322 SGTC_1243 0416-0003 5.65 µM 0.904747095279309 0.264702259103628 no 875 0.18279969249701 191 2141977 SGTC_488 nitrendipine 139 µM 0.904090148192295 0.264871440888713 no 876 0.182973800953783 197 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1669 st015249 58.4 µM 0.899079072621264 0.266163735449498 no 877 0.184305272082844 209 722793 SGTC_572 0960-0087 17.7 µM 0.898076484136229 0.266422673365495 no 878 0.184572387507347 249 6796365 SGTC_1168 k815-0004 80.5 µM 0.897983765619107 0.266446626156654 no 879 0.18459710226695 227 642433 SGTC_2700 st077718 96.8 µM 0.897888549695126 0.26647122525868 no 880 0.184622484869278 203 904970 SGTC_603 3794-0023 45.9 µM 0.897248478512724 0.266636617918607 no 881 0.184793170976159 216 3802260 SGTC_799 1310-0557 151 µM 0.896378270375034 0.26686156056156 no 882 0.185025384374213 211 5354492 SGTC_1488 4013-0813 75.9 µM 0.895415704570222 0.267110488641119 no 883 0.185282454313598 202 2910057 SGTC_520 3584-0023 682 µM 0.895188583211942 0.26716924133364 no 884 0.185343143345884 211 1340790 SGTC_2777 climbazole 1.536 µM 0.893146822004737 0.267697705305982 no 885 0.185889275803683 224 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1687 st020778 55.3625 µM 0.891702484802003 0.268071857379863 no 886 0.186276210672095 201 4259299 SGTC_517 1365-0151 113 µM 0.891238753505611 0.268192041657931 no 887 0.18640054906384 197 768657 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.889731292916034 0.268582914323819 no 888 0.186805093443068 213 97141 SGTC_2800 7887935 81.82 µM 0.886468847891248 0.269429819816577 no 889 0.18768246687377 209 2961002 SGTC_1196 1588-0294 184 µM 0.886458868038403 0.269432412561539 no 890 0.187685154667618 208 6144269 SGTC_3110 9122132 49.47 µM 0.886175672057538 0.26950599149967 no 891 0.187761435484094 184 918317 SGTC_15 0266-0086 27.098 µM 0.885294003606102 0.269735127814649 no 892 0.187999041626321 225 1712902 YIL048W NEO1 SGTC_167 3672-0051 66.205 µM 0.884297332591281 0.26999426951395 no 893 0.188267863911415 204 3237971 SGTC_1034 k072-0165 12.7 µM 0.884066646121379 0.270054267421454 no 894 0.188330118490149 223 5835461 SGTC_1685 st024049 53.0905 µM 0.879397115980771 0.27127017072769 no 895 0.189592997652765 219 1941139 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.876835522311557 0.271938343608469 no 896 0.190287990907469 221 5024745 SGTC_575 k072-0246 11.9 µM 0.87558232946228 0.272265527706711 no 897 0.190628567575655 204 6796779 SGTC_1937 st074714 47.2 µM 0.875267472083193 0.272347761535084 no 898 0.190714194250693 188 17250970 SGTC_947 3447-0010 211 µM 0.871674248517641 0.273287105550697 no 899 0.191693056253287 226 748350 SGTC_370 0180-0345 38.7 µM 0.870743181591016 0.273530767499409 no 900 0.191947197526717 194 3989527 SGTC_2830 7992007 71.43 µM 0.869869632473922 0.27375947465441 no 901 0.19218582632427 220 1952075 SGTC_887 0885-0007 9.62 µM 0.869651171960107 0.273816685397336 no 902 0.192245531885624 222 5719458 SGTC_2987 9018338 71.43 µM 0.868877443750773 0.274019357954186 no 903 0.192457084112468 236 5055682 SGTC_1546 5-methoxyflavanone 78.7 µM 0.867458659544223 0.274391190802715 no 904 0.192845376702894 196 147795 SGTC_2136 5328288 199.296 µM 0.866780105358749 0.27456911326949 no 905 0.193031252331583 197 262395 SGTC_2802 7925815 54.55 µM 0.863435903124452 0.275446821057468 no 906 0.193948923267907 207 1262923 SGTC_1098 clofazimine 15.1 µM 0.863331192642687 0.27547432527966 no 907 0.193977699366038 227 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_849 0386-0493 241 µM 0.862100907498932 0.275797584486907 no 908 0.194315996026711 226 726119 SGTC_3239 9133757 49.47 µM 0.860303689695958 0.276270140865417 no 909 0.194810829760877 240 17036923 SGTC_1902 st060212 70.5 µM 0.860002005072795 0.276349504061483 no 910 0.194893968617636 210 688944 SGTC_227 fluconazole 33.516 µM 0.856389957518996 0.277300581292 no 911 0.195891058812715 253 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3041 9091929 49.47 µM 0.856232258459551 0.277342140992574 no 912 0.195934661362914 212 25236887 SGTC_1202 1988-0068 29.6 µM 0.856152014222177 0.277363289570516 no 913 0.195956850524006 213 2850480 SGTC_2801 7907800 81.82 µM 0.854138350059343 0.277894254022132 no 914 0.196514168577251 234 6620925 SGTC_1970 st070122 35.8 µM 0.853695107867337 0.278011195039754 no 915 0.196636972738809 241 102928 SGTC_920 mycophenolic acid 780.421 nM 0.853232014854265 0.278133398961529 no 916 0.196765326391425 205 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1300 1094-0077 113 µM 0.852757537725822 0.278258634163542 no 917 0.196896887945715 221 5532636 SGTC_1215 3852-0577 11.2 µM 0.852213857867617 0.278402168774473 no 918 0.197047703275775 208 2884876 SGTC_196 k015-0023 18.111 µM 0.850551323865334 0.278841311047133 no 919 0.197509319333604 199 5211998 SGTC_2753 fluvastatin 17.09 µM 0.850150518898469 0.278947230207057 no 920 0.197620703820538 223 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1973 st070275 50.2 µM 0.850135347717525 0.27895123982008 no 921 0.197624920667153 199 17118334 SGTC_2702 st077768 96.8 µM 0.850119528647186 0.278955420694573 no 922 0.197629317653266 208 6484119 SGTC_1311 1190-0148 100 µM 0.84938467093532 0.279149672263284 no 923 0.197833640032357 231 1961333 SGTC_1068 loratadine 26.9 µM 0.848998971093005 0.279251654090733 no 924 0.197940932403317 220 3957 A H1 histamine antagonist. SGTC_883 0850-0245 24.6 µM 0.848570357870349 0.279365003762137 no 925 0.198060203460544 232 6823229 YPR165W RHO1 SGTC_335 4077-0256 27.6 µM 0.847042733610844 0.279769176048507 no 926 0.198485651364645 236 3121989 SGTC_1408 3909-7976 48.8 µM 0.846237158285046 0.279982425906182 no 927 0.198710228351147 243 24152374 SGTC_3070 9117005 49.47 µM 0.844273506801892 0.280502568682117 no 928 0.199258293493571 198 8779016 SGTC_1182 1222-0449 220 µM 0.843401778033385 0.280733626784934 no 929 0.199501888930669 230 658318 SGTC_896 0964-0007 44.5 µM 0.841486750735651 0.281241541805111 no 930 0.200037652204035 211 6756758 SGTC_2468 5987765 72.9 µM 0.836941719029818 0.282448775458541 no 931 0.201312664279902 211 26772094 SGTC_438 sphingosine 6.67 µM 0.836592234860348 0.282541707171628 no 932 0.201410905928371 206 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_400 oxethazaine 37.5 µM 0.836369988205208 0.282600812665494 no 933 0.201473395454795 230 4621 A local anesthetic. SGTC_360 0957-0399 1.01 µM 0.83606562167271 0.282681767211627 no 934 0.201558993635642 223 6752301 YPR165W RHO1 SGTC_783 0848-0141 92.7 µM 0.835305730282537 0.282883929595699 no 935 0.201772795923705 251 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2585 alliin 100 µM 0.834429494684943 0.283117130482736 no 936 0.202019501220456 223 87310 A garlic compound which reacts with lipids. SGTC_1293 1000-1278 195 µM 0.83165607937894 0.283855853261259 no 937 0.202801549148997 239 678847 SGTC_2195 6536160 144.242 µM 0.831508587800504 0.283895164723558 no 938 0.202843189428519 220 3834386 SGTC_275 trichlorophene 5.69 µM 0.830035145435438 0.284288029605568 no 939 0.203259456552313 222 62616 SGTC_1943 st076331 65.2 µM 0.829792134919903 0.2843528486106 no 940 0.203328159208165 217 24208415 SGTC_954 1189-0853 2.85 µM 0.827502167879138 0.284964005755748 no 941 0.203976246924129 234 2828194 SGTC_27 0485-0001 32.618 µM 0.826897863065045 0.285125389868702 no 942 0.204147477365376 224 2054479 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.826661038905568 0.285188647408653 no 943 0.204214605097793 221 688667 SGTC_2540 epiandrosterone 100 µM 0.825456450668284 0.285510505600759 no 944 0.204556248667036 249 441302 A steroid. SGTC_2093 5331342 194.4 µM 0.825195508344358 0.285580250483099 no 945 0.204630301543248 230 33839 SGTC_2477 5967686 25.23 µM 0.824937252109771 0.28564928540811 no 946 0.204703607835627 219 776118 SGTC_2314 7727897 200 µM 0.824931047829252 0.285650943982838 no 947 0.204705369119033 208 900724 SGTC_1378 2093-0007 380 nM 0.824824403059229 0.285679453777635 no 948 0.204735645056096 247 3618014 SGTC_3025 9087895 49.47 µM 0.824160446332349 0.285856982566274 no 949 0.204924199078855 235 17173641 SGTC_2576 guaiol 23.12 µM 0.819696549392535 0.287051899401333 no 950 0.206194558802697 222 227829 SGTC_347 4534-1311 26.2 µM 0.817676743572932 0.287593346683807 no 951 0.206770896722526 235 2862016 SGTC_1047 2043-3044 82 µM 0.817502004292056 0.287640211544904 no 952 0.206820802177438 263 669592 SGTC_1236 0330-0013 258 µM 0.817155187381521 0.28773323810524 no 953 0.206919874038258 232 4617066 SGTC_3000 9075062 71.4286 µM 0.815278830001928 0.288236779021452 no 954 0.207456361894929 222 17057871 SGTC_2308 7584454 197.62 µM 0.813763237894017 0.288643807859 no 955 0.207890299453333 227 893577 SGTC_2224 6650123 117.647 µM 0.812452012820029 0.288996169978078 no 956 0.208266155639826 235 2908370 SGTC_1212 0520-0165 585 µM 0.80973519222897 0.289726897449383 no 957 0.209046193549614 242 5403258 SGTC_1496 4469-0713 57.4 µM 0.809443815083293 0.289805318922992 no 958 0.209129954117349 241 746691 SGTC_1435 4092-0789 56.7 µM 0.808781551133436 0.28998359819138 no 959 0.209320404934923 241 2248285 SGTC_2117 5521686 200 µM 0.80856992380446 0.290040578408588 no 960 0.209381285262093 230 803312 SGTC_1062 mesoridazine 14.2 µM 0.807841765704259 0.290236673544931 no 961 0.20959083923022 224 4078 A neuroleptic. SGTC_1913 st060213 96.1 µM 0.807355194926049 0.290367743105194 no 962 0.209730936390823 242 688959 SGTC_1380 2291-0730 164 µM 0.807216087830334 0.29040522004616 no 963 0.209770999282944 234 2999191 SGTC_2931 9014674 55.67 µM 0.805516947523152 0.29086316929424 no 964 0.210260715289575 239 2996810 SGTC_296 1222-0039 74.9 µM 0.804787474090519 0.291059879180223 no 965 0.210471165557099 217 5984176 SGTC_672 1441-0018 53.7 µM 0.804096358193917 0.291246302875405 no 966 0.210670663833015 227 251141 SGTC_2192 5915882 198.485 µM 0.803149171119304 0.291501890490836 no 967 0.210944260033289 220 2876149 SGTC_2767 sibutramine 71.45 µM 0.802318146127327 0.291726219210722 no 968 0.211184474146068 225 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_589 1227-0070 34.1 µM 0.801339710281949 0.291990443419962 no 969 0.211467503851388 234 2841384 SGTC_1510 1123-0200 71.5 µM 0.799631554867274 0.292451993487899 no 970 0.211962149755595 243 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2422 chlorphenesin carbamate 384.24 µM 0.799414933361963 0.292510549663018 no 971 0.212024927107667 221 2724 A muscle relaxant with antifungal properties. SGTC_224 benfluorex 43.875 µM 0.796348282330127 0.293340097289095 no 972 0.212914814714572 250 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3008 9078912 71.4286 µM 0.79443190389033 0.293859042110219 no 973 0.213472018572163 242 16648731 SGTC_3113 9123498 49.47 µM 0.794145480740139 0.293936640399545 no 974 0.213555371560852 275 8897275 SGTC_2178 5812956 200 µM 0.794051534434785 0.293962094569841 no 975 0.213582715328971 242 5403383 SGTC_2325 6158266 200 µM 0.793201631227741 0.294192416891204 no 976 0.213830178643798 237 3623240 SGTC_1842 st055362 61.2 µM 0.792081984817354 0.294495966363436 no 977 0.214156436858962 220 676032 SGTC_2654 protoveratrine a 100 µM 0.791743667073834 0.294587716761541 no 978 0.214255077565986 256 5702278 A heart drug and vasodilator. SGTC_2690 usnic acid 100 µM 0.789678647101699 0.295148027495554 no 979 0.214857732334945 245 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1781 st038725 66.3 µM 0.788688504466526 0.295416861087821 no 980 0.215147044164648 252 4270275 YIL048W NEO1 SGTC_2095 5432005 200 µM 0.788564856010722 0.295450440785862 no 981 0.215183189140256 255 783734 SGTC_2220 6782180 200 µM 0.787355457622342 0.295778974392836 no 982 0.215536906846346 221 833803 SGTC_1267 0828-0272 9.49 µM 0.786065216495211 0.296129653889565 no 983 0.215914640475823 239 745334 SGTC_2537 larixol 68.93 µM 0.784419514106248 0.296577222182728 no 984 0.216396995879148 242 6708759 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.784198999267666 0.296637217346083 no 985 0.216461676132308 244 66535 A nucleotide analog. SGTC_2731 amoxapine 43.43 µM 0.78354779981616 0.296814420706179 no 986 0.216652747818715 289 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_92 0063-0024 660.874 µM 0.782360444957512 0.297137646475338 no 987 0.217001386528097 246 3594437 SGTC_942 3253-1115 227 µM 0.781906743200335 0.297261197187383 no 988 0.2171346909026 263 46497897 SGTC_127 0180-0333 59.125 µM 0.780382397781358 0.297676474234939 no 989 0.217582912780278 206 771601 SGTC_316 k060-0003 58.6 µM 0.779814701003404 0.297831199352534 no 990 0.217749975953342 241 6152314 SGTC_91 0417-1751 58.384 µM 0.778825501673554 0.298100892111773 no 991 0.218041256650936 251 6795624 SGTC_118 0083-0097 135.343 µM 0.778532900998364 0.298180687324906 no 992 0.218127459188233 279 5207356 SGTC_782 0083-0095 30.5 µM 0.778367484449678 0.29822580242301 no 993 0.218176200937883 245 3591729 An indicator and reagent. SGTC_233 rapamycin 362 pM 0.777068211168054 0.298580269460666 no 994 0.218559263868967 257 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3033 9090887 49.47 µM 0.774812169153336 0.299196216414476 no 995 0.219225328712887 242 19325384 SGTC_2646 retinol 96.75 µM 0.774637290148767 0.299243986135289 no 996 0.219277007975718 247 445354 A vitamin A analog and teratogen. SGTC_2958 9077254 16.72 µM 0.774263381820642 0.29934613405387 no 997 0.219387526755402 241 16457351 SGTC_1232 0279-0259 161 µM 0.773101581136011 0.299663626943565 no 998 0.219731132719621 241 1560000 SGTC_1013 4112-3890 241 µM 0.772356614527151 0.299867289089193 no 999 0.219951621260606 261 705171 SGTC_2242 6630449 61.2675 µM 0.768958147625525 0.300797170315753 no 1000 0.220959078216768 229 691249 YDR170C SEC7 SGTC_1866 st057638 64 µM 0.768896192284563 0.300814134471632 no 1001 0.220977469021352 227 688802 SGTC_818 4072-2707 53.5 µM 0.767218594417313 0.301273645948369 no 1002 0.221475779606331 236 882871 SGTC_1856 st057054 55.7 µM 0.766795586725496 0.301389562033295 no 1003 0.22160153037078 258 1266018 SGTC_2940 9060638 45.86 µM 0.764381018790495 0.302051606029972 no 1004 0.222320108387773 229 4027022 SGTC_49 0717-0965 32.132 µM 0.762008442421809 0.302702771834254 no 1005 0.22302748271865 270 5889349 YGL099W LSG1 SGTC_769 0302-0231 76 µM 0.761997798893225 0.302705694421952 no 1006 0.223030658930204 267 571869 YER009W NTF2 SGTC_484 loperamide 105 µM 0.759862103567136 0.30329238676776 no 1007 0.223668508035793 217 3955 An opioid-receptor agonist. SGTC_304 1310-0298 97 µM 0.758129206691228 0.303768800385337 no 1008 0.22418681828172 280 1550234 SGTC_1244 0416-0015 52.5 µM 0.75665331272489 0.304174821031694 no 1009 0.224628796160145 241 96201 SGTC_730 1436-0052 41.2 µM 0.75597305892831 0.304362041237845 no 1010 0.224832674328158 221 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1067 clotrimazole 1.36 µM 0.755373485826443 0.3045270989372 no 1011 0.2250124587215 239 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_872 0588-0139 234 µM 0.753817911100808 0.304955521852635 no 1012 0.225479283716372 232 2047100 SGTC_2827 7993847 71.43 µM 0.751338601163531 0.305638904719547 no 1013 0.22622445186016 230 2985692 SGTC_2345 9052315 157.45 µM 0.750619702544403 0.305837184661531 no 1014 0.226440780116487 248 6469265 SGTC_554 4483-2211 187 µM 0.747049068163634 0.306822846536168 no 1015 0.227516971210687 248 747107 SGTC_1950 st077106 7.18 µM 0.746108852118806 0.307082622947825 no 1016 0.227800831183306 232 13831864 SGTC_929 2805-0021 398 µM 0.745304436641134 0.307304955322764 no 1017 0.228043849824727 271 3098024 SGTC_1386 3228-0095 33.8 µM 0.744365781481517 0.307564479756228 no 1018 0.228327607310552 248 870181 SGTC_2000 st075254 36.4 µM 0.742408391020313 0.308105979447146 no 1019 0.228919968569311 243 17234175 SGTC_2681 menadione 3.18 µM 0.740703659427621 0.308577923268722 no 1020 0.229436570024081 276 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2417 cerulenin 830 nM 0.740420094024233 0.308656457214465 no 1021 0.229522564951842 263 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3211 9128781 49.47 µM 0.736648625709435 0.309701803327368 no 1022 0.230668028151163 243 17194361 SGTC_85 0868-0259 160.055 µM 0.735658602705702 0.309976465865999 no 1023 0.230969244434252 244 83173 SGTC_2132 5317594 122.667 µM 0.7350070369152 0.31015728795737 no 1024 0.231167604254476 275 794577 SGTC_2736 butenafine 14.65 µM 0.734137753321713 0.310398602429972 no 1025 0.231432393065075 261 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1591 genipin 88.4 µM 0.731753251409889 0.311060962726671 no 1026 0.232159593646168 273 442424 A DNA cross-linking agent. SGTC_3348 9149464 3.537 µM 0.731536022164384 0.311121334530962 no 1027 0.23222590510766 247 1951442 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.731510450517859 0.311128441672878 no 1028 0.232233711809103 252 4213774 SGTC_1308 1187-1617 41.4 µM 0.731425570584763 0.311152032904645 no 1029 0.23225962562989 263 2882570 SGTC_2978 9011784 42.97 µM 0.730466346978953 0.311418690066469 no 1030 0.232552588144666 234 2994934 SGTC_1602 st001878 87.6 µM 0.72558279543414 0.312777813892993 no 1031 0.234047285640391 279 595405 YLR310C CDC25 SGTC_1369 1866-0067 208 µM 0.723614406688463 0.313326351066278 no 1032 0.234651247116888 255 3531355 SGTC_1397 3532-0190 20.1 µM 0.723318851103747 0.313408750194812 no 1033 0.234742006912377 233 5322280 SGTC_2463 5473429 200 µM 0.72005567778831 0.314319121744968 no 1034 0.235745357645508 248 5399405 SGTC_1102 cgs 12066b 26.1 µM 0.718977465418251 0.314620173990742 no 1035 0.236077402190261 254 6438352 A 5-HT1B full agonist. SGTC_863 0466-0191 129 µM 0.717770375186564 0.314957357039524 no 1036 0.236449441257427 278 765160 YPR165W RHO1 SGTC_2316 5844804 197.44 µM 0.714395756630219 0.315900825397887 no 1037 0.23749124757933 262 776813 SGTC_1651 st011928 86.1 µM 0.713417438709337 0.316174566094326 no 1038 0.237793742601539 257 720198 SGTC_1048 3161-0300 24.5 µM 0.713341372361118 0.316195854254267 no 1039 0.237817271098918 243 2165101 SGTC_3156 9099931 49.47 µM 0.713115751294389 0.316259000836945 no 1040 0.237887066691985 272 18111053 SGTC_1674 st016616 23.6 µM 0.712999103629144 0.316291650162249 no 1041 0.237923155904642 251 625830 SGTC_773 4358-1457 44.6 µM 0.711141321806672 0.316811830524369 no 1042 0.238498332944293 278 1186886 SGTC_2518 prenyletin 46.28 µM 0.708920748386955 0.317434068239213 no 1043 0.2391868293297 243 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3001 9076041 71.4286 µM 0.708890228182718 0.317442624054981 no 1044 0.239196299783913 259 16004211 SGTC_1762 st045503 25.4615 µM 0.708161158848666 0.317647035121995 no 1045 0.239422591730009 265 4645554 SGTC_1626 st003712 1.76 µM 0.705921141350057 0.318275422300868 no 1046 0.240118589687 286 24207035 SGTC_3173 9105693 49.47 µM 0.704342819364022 0.318718499891244 no 1047 0.240609653157497 291 17096658 SGTC_1667 st014849 34.6 µM 0.70178426594071 0.319437305563479 no 1048 0.241406856248057 268 5348460 SGTC_3264 9137442 49.47 µM 0.70148377806011 0.319521769904096 no 1049 0.241500577384252 267 17015726 SGTC_2116 5511452 16.8835 µM 0.701090820346013 0.31963224078172 no 1050 0.241623169355487 279 870744 SGTC_1029 k015-0030 64.7 µM 0.700929210692828 0.319677678204161 no 1051 0.241673596914158 275 2208316 SGTC_614 0462-0418 107 µM 0.700257660149542 0.319866517233205 no 1052 0.241883204083913 253 5188303 SGTC_1668 st014914 51.6 µM 0.699420540500566 0.320101979430239 no 1053 0.242144627422119 276 2839556 SGTC_2952 9073731 13.78 µM 0.699203555388923 0.320163024103429 no 1054 0.242212414496732 276 16457353 SGTC_1118 chelidonine 707.474 nM 0.697661573530197 0.320596971789287 no 1055 0.242694432363712 271 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2469 5655019 90.81 µM 0.697166493893159 0.320736350169108 no 1056 0.242849302498689 270 2788239 SGTC_104 0074-0074 590.992 µM 0.695668312453544 0.321158282885886 no 1057 0.24331828717598 253 3943124 SGTC_1487 3970-0795 2.82 µM 0.695556815520462 0.321189692999055 no 1058 0.243353209285228 264 3765103 SGTC_2250 alverine citrate 130 µM 0.693706545038029 0.321711124486209 no 1059 0.243933130305 261 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_82 0054-0107 293.755 µM 0.693464192047319 0.321779448915754 no 1060 0.244009144981727 263 3104697 SGTC_820 1582-0060 59.9 µM 0.693290162372155 0.321828515276777 no 1061 0.244063737745525 274 3848840 SGTC_1382 3002-2117 298 µM 0.692473557969171 0.322058792243955 no 1062 0.244319992885065 303 1497314 SGTC_172 1112-0046 2.638 µM 0.692302060341377 0.322107162110576 no 1063 0.24437382824297 280 2802135 YIL048W NEO1 SGTC_2054 5233173 129 µM 0.69015182425119 0.322713878682686 no 1064 0.245049357824031 220 6889 SGTC_1394 3474-0001 65.7 µM 0.689845048464578 0.322800477921477 no 1065 0.245145817946826 253 5017666 YIL048W NEO1 SGTC_1694 st024011 44.9 µM 0.688319192674173 0.323231351972811 no 1066 0.245625899041602 284 2787533 SGTC_1912 st060209 90.8 µM 0.683554998208281 0.324578198913808 no 1067 0.247128104880448 288 688787 SGTC_1414 3917-0015 5.4 µM 0.682478628591767 0.324882809459492 no 1068 0.247468175958499 278 6618702 SGTC_2287 7945887 168.79 µM 0.68040387797785 0.325470290244959 no 1069 0.248124383110289 270 1245853 SGTC_2395 5646831 180.19 µM 0.679299028560152 0.325783313572642 no 1070 0.248474205921033 291 6808628 SGTC_2892 9047358 58.44 µM 0.677841296791605 0.326196502663594 no 1071 0.248936161903104 277 6466771 SGTC_1850 st056238 17 µM 0.67649509130021 0.326578269606162 no 1072 0.249363180776032 287 5393177 SGTC_674 0498-0004 451 µM 0.676316002367794 0.326629070675939 no 1073 0.249420017447724 272 4231473 SGTC_665 3914-0008 307 µM 0.675151587322221 0.326959451589229 no 1074 0.249789730617599 282 1069549 SGTC_351 caspofungin 25 nM 0.674363352523546 0.327183175446028 no 1075 0.25004016793128 268 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2352 9027995 87.8 µM 0.673813002753732 0.327339417469452 no 1076 0.250215103555651 270 2997347 SGTC_1150 3909-7983 10.9 µM 0.673397080006834 0.32745751629014 no 1077 0.250347352901633 284 23965914 SGTC_1092 toremifene 6.32 µM 0.671018007694743 0.328133371492688 no 1078 0.251104528923784 299 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1440 4100-1550 40 µM 0.670218007958517 0.328360764834086 no 1079 0.251359412937589 289 742806 SGTC_1281 0884-0031 11.8 µM 0.670150089856798 0.328380072925663 no 1080 0.251381058289299 289 1548255 SGTC_1512 0259-0544 12.2 µM 0.669115522720835 0.328674241397555 no 1081 0.251710894363654 269 18476 SGTC_1600 coumarin 106 71.1 µM 0.669088758100342 0.328681853050714 no 1082 0.251719430372192 299 100336 A hepatotoxic, DNA x-linker. SGTC_2420 aureobasidin a 50 nM 0.668063801277992 0.328973396376749 no 1083 0.252046433615053 264 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2951 9072950 58.06 µM 0.667176525779716 0.329225861062885 no 1084 0.252329691754923 285 16488155 SGTC_3079 9117512 49.47 µM 0.665423110269483 0.329725005545101 no 1085 0.252889953769083 331 7185044 SGTC_2157 5649910 96.377 µM 0.665055358340054 0.329829731943675 no 1086 0.253007543116746 285 2858091 SGTC_3104 9120930 49.47 µM 0.664857907141973 0.329885966529296 no 1087 0.253070690364152 285 17014836 SGTC_2610 ononetin 44.17 µM 0.663554288694051 0.330257336701751 no 1088 0.253487811075412 278 259632 SGTC_1833 st055984 71 µM 0.660453140225517 0.331141452535897 no 1089 0.254481540119763 271 676288 SGTC_2733 amorolfine 100 µM 0.660289860326669 0.331188028651308 no 1090 0.254533917881451 310 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1614 st002383 48.6 µM 0.659417265252556 0.331436983460204 no 1091 0.25481392910944 257 1947235 SGTC_3336 9143619 71.43 µM 0.659204626098108 0.331497661541025 no 1092 0.254882188336687 279 45595730 SGTC_2694 st077685 81.9 µM 0.658464657396682 0.331708851289249 no 1093 0.255119800030161 259 2838096 SGTC_1073 triclabendazole 3.09 µM 0.65766504009752 0.331937125105394 no 1094 0.255376695691712 271 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1142 3253-1408 9.78 µM 0.656211315323693 0.332352292558137 no 1095 0.255844084689791 289 256655 SGTC_2944 9067346 25.62 µM 0.656132044430828 0.332374937355244 no 1096 0.255869584011198 295 6473075 SGTC_1449 4112-4002 201 µM 0.651768465093561 0.333622394401479 no 1097 0.25727527391126 282 2059539 SGTC_1184 1269-1718 139 µM 0.651685008641929 0.333646270865342 no 1098 0.257302197762456 284 5403821 SGTC_1503 4585-0012 61.3 µM 0.650293172434 0.334044567335176 no 1099 0.257751433235687 286 2922052 SGTC_176 1486-1328 72.834 µM 0.649776003948156 0.334192611145762 no 1100 0.257918460605525 286 22310231 SGTC_1027 k015-0025 8.67 µM 0.649001078848831 0.334414488230512 no 1101 0.258168839435826 284 3598955 SGTC_286 k060-0067 22.9 µM 0.647907802226961 0.334727614317595 no 1102 0.258522292039248 276 5985051 SGTC_580 1123-0028 41 µM 0.647870938234147 0.334738174563124 no 1103 0.258534214408669 301 1677248 YPR107C YTH1 SGTC_2197 6588183 93.1375 µM 0.647699768934301 0.334787210297461 no 1104 0.258589576863769 276 884136 SGTC_2029 5175081 200 µM 0.647233342699241 0.334920844074311 no 1105 0.258740467434155 276 1380876 SGTC_627 1391-0720 175 µM 0.646179734835544 0.33522278565982 no 1106 0.259081481041352 314 997839 SGTC_3083 9117465 49.47 µM 0.645962696125776 0.335284997568327 no 1107 0.25915175724059 307 16420915 SGTC_3181 9108277 49.47 µM 0.645029156149258 0.335552638666193 no 1108 0.259454145777542 306 17097298 SGTC_399 oxolinic acid 75 µM 0.643775595438908 0.335912159322338 no 1109 0.259860480624806 285 4628 A DNA gyrase inhibitor. SGTC_282 k297-0036 65.7 µM 0.643292397598131 0.336050780373261 no 1110 0.26001719417797 293 5061378 SGTC_3074 9116018 49.47 µM 0.642394975504298 0.336308294313897 no 1111 0.260308380620357 334 17027303 SGTC_323 4013-0906 34.3 µM 0.642266246830803 0.336345239118626 no 1112 0.260350162972065 260 2910086 SGTC_3094 9117742 49.47 µM 0.640494999473395 0.336853742982343 no 1113 0.260925419534625 309 17149698 SGTC_755 1995-0008 37.3 µM 0.637741039446934 0.337644964201702 no 1114 0.261821132958983 266 689533 SGTC_1031 k035-0009 16 µM 0.633376099973362 0.338900494995235 no 1115 0.263244034276809 296 5180959 SGTC_2771 fluoxetine 41.05 µM 0.632766656338178 0.339075938169896 no 1116 0.263443017047217 308 3386 A selective serotonin reuptake inhibitor. SGTC_840 0245-0196 390 µM 0.631634697128963 0.339401892758533 no 1117 0.263812804286309 286 3827528 SGTC_291 SEC14.278 35.5 µM 0.629149973284916 0.34011780541166 no 1118 0.264625438321376 293 1068044 SGTC_1431 4049-0260 9.09 µM 0.628617528072965 0.340271291662644 no 1119 0.264799741132008 305 3854841 SGTC_1222 0366-0074 1.18 µM 0.627906888583824 0.340476186632123 no 1120 0.265032469042821 315 286520 SGTC_1617 st002906 78 µM 0.627003738393271 0.340736655159315 no 1121 0.26532839232075 296 5150859 SGTC_1940 st075990 51.1 µM 0.626041352871885 0.341014290748453 no 1122 0.26564390892644 299 1084979 SGTC_2409 alverine citrate 63.97 µM 0.625432388490959 0.341190013472391 no 1123 0.265843655198196 262 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2516 gossypol 71.55 µM 0.625127483390228 0.341278009812887 no 1124 0.265943695642607 302 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_555 4296-0685 37 µM 0.619823485715206 0.342810133554786 no 1125 0.267687002319708 320 2908540 YHR072W ERG7 SGTC_447 ml7 120 µM 0.61920693468705 0.342988400197337 no 1126 0.267890022015737 314 4216 Selective myosin light chain kinase inhibitor. SGTC_1995 st072814 61.1 µM 0.618223881896241 0.343272707712127 no 1127 0.268213884788815 294 5769371 SGTC_3167 9103034 49.47 µM 0.617906087309428 0.343364635686989 no 1128 0.268318623053643 298 5127859 SGTC_1197 1601-0112 267 µM 0.617340976767869 0.34352812727567 no 1129 0.268504922146007 300 7350313 SGTC_2199 6590217 200 µM 0.616450442212789 0.343785826386144 no 1130 0.268798635173664 292 703109 SGTC_120 rhodamine 6G 52.259 µM 0.615136675545016 0.344166131136485 no 1131 0.269232231586822 317 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3194 9111903 49.47 µM 0.615103972892067 0.344175599802948 no 1132 0.269243029265402 326 17087251 SGTC_189 3970-0742 2.116 µM 0.614526848401208 0.344342715444467 no 1133 0.269433618491276 309 2891807 SGTC_753 1322-0200 289 µM 0.613160867811859 0.344738378064821 no 1134 0.269884988358206 286 5403907 SGTC_698 k064-0052 127 µM 0.611951819425277 0.345088726295112 no 1135 0.270284817641199 326 5088751 SGTC_391 gliotoxin 8.33 µM 0.611121521372962 0.345329400277123 no 1136 0.270559566553579 306 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_970 1315-0089 19.5 µM 0.610611529669117 0.345477259818814 no 1137 0.270728393965626 287 6811083 YLR033W RSC58 SGTC_339 3091-4833 71.4 µM 0.60832924441461 0.346139240872326 no 1138 0.271484564389079 301 3240077 SGTC_3087 9117406 49.47 µM 0.608100775658389 0.346205534592755 no 1139 0.271560318914409 281 42546093 SGTC_516 3992-2719 87.3 µM 0.606721799506552 0.346605765717247 no 1140 0.272017776313889 287 5350887 YDR037W KRS1 SGTC_985 1493-0307 8.71 µM 0.602720006304878 0.347768206120797 no 1141 0.273347485045441 314 3278274 SGTC_152 4469-0003 551.229 µM 0.602592948631755 0.347805137338268 no 1142 0.273389756209545 297 697280 SGTC_10 0279-0212 42.575 µM 0.602414924448488 0.347856885165062 no 1143 0.273448989005327 286 39851 YBR002C RER2 SGTC_1885 st057546 99.9 µM 0.602207810167612 0.347917092428309 no 1144 0.273517908749279 293 702008 SGTC_2284 7945075 39.21 µM 0.601368202938068 0.348161202037846 no 1145 0.273797386097186 317 1245402 SGTC_2645 abamectin 100 µM 0.601017172406214 0.348263280235437 no 1146 0.273914274346545 286 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3029 9088683 49.47 µM 0.599697425265999 0.348647155437521 no 1147 0.274353952246832 280 25236615 SGTC_1119 parthenolide 318.541 nM 0.598469873752362 0.349004352845669 no 1148 0.274763227386124 333 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2425 5628681 7.85 µM 0.598250010025721 0.349068343734625 no 1149 0.274836563420217 315 5714958 SGTC_466 geldanamycin 89.2 µM 0.596698588909797 0.349520003587793 no 1150 0.275354317443987 286 5288382 HSP90 inhibitor. SGTC_1216 1165-0504 9.65 µM 0.593998653919537 0.350306534183106 no 1151 0.276256506644044 319 6304004 SGTC_2514 salinomycin 42.74 µM 0.593715078937042 0.350389181064216 no 1152 0.276351347952014 324 23682228 A polyether potassium ionophore. SGTC_310 1273-0058 1.06 µM 0.592827450355188 0.350647922910261 no 1153 0.276648317452217 275 2734232 SGTC_3258 9138477 49.47 µM 0.592566217475969 0.350724084943337 no 1154 0.276735746620791 319 4970355 SGTC_684 1140-0066 328 µM 0.592170470986271 0.350839475635169 no 1155 0.276868220457041 306 6813534 SGTC_816 0325-0417 81.3 µM 0.591200657014608 0.351122309528026 no 1156 0.277192991291645 305 68101 SGTC_1279 0874-0590 65.2 µM 0.59007100734234 0.351451861462853 no 1157 0.277571522653662 306 3523074 SGTC_3286 9117135 37.221 µM 0.589994895564576 0.35147406951934 no 1158 0.277597035830171 302 3438150 SGTC_486 niguldipine 82 µM 0.586104129671187 0.352609999364076 no 1159 0.278902770653776 306 1236 A calcium channel blocker. SGTC_2386 9075165 157.42 µM 0.585803760692196 0.352697748516314 no 1160 0.27900369811976 299 16452277 SGTC_2571 chrysanthemic acid 100 µM 0.584952260419622 0.352946546577328 no 1161 0.27928990862132 330 2743 An insecticide. SGTC_2815 7968870 71.43 µM 0.584026945025203 0.353216983825461 no 1162 0.279601091894612 315 2977326 YHR190W ERG9 SGTC_1319 1306-0155 43.7 µM 0.583496311786143 0.35337210277661 no 1163 0.279779619586121 311 3122360 SGTC_1956 st077085 54 µM 0.581442150104385 0.353972821214102 no 1164 0.280471248286228 327 24208685 SGTC_2254 7938975 95.19 µM 0.581131247192404 0.354063773293545 no 1165 0.280576000221569 316 2969277 SGTC_2906 7926292 26.41 µM 0.580907187526528 0.354129325261743 no 1166 0.280651503960843 326 2966319 SGTC_42 0133-0086 60.653 µM 0.576166735420674 0.355517225146033 no 1167 0.282251243532216 329 162923 Model of phenazepam hydroxylation. SGTC_2505 galangin 7.89 µM 0.576016132259471 0.355561349963206 no 1168 0.28230213875692 331 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1144 3486-0183 12.5 µM 0.575080517706465 0.355835516516046 no 1169 0.282618421665864 339 6744069 SGTC_464 bw-b 70c 158 µM 0.57464528801376 0.355963078889229 no 1170 0.282765608344515 329 5353454 SGTC_1442 4112-3290 3 µM 0.574249436496067 0.356079113835826 no 1171 0.282899510019527 318 704353 SGTC_650 1328-0195 38 µM 0.571899741604917 0.356768147993132 no 1172 0.283694949553779 315 2780821 SGTC_663 1486-0733 13.9 µM 0.570936076491584 0.357050872444406 no 1173 0.284021487469185 310 722445 YPR165W RHO1 SGTC_3081 9117243 49.47 µM 0.570717783242335 0.357114927223065 no 1174 0.28409548110688 317 45595589 SGTC_2062 5245942 200 µM 0.569586704504576 0.357446889251137 no 1175 0.284479024103832 313 1376160 SGTC_560 2332-1943 155 µM 0.569193668333524 0.357562267310918 no 1176 0.284612358538202 308 21177716 SGTC_624 k048-0052 28 µM 0.568427460345572 0.357787229553993 no 1177 0.284872374333112 303 6835531 SGTC_475 α-linolenic acid 10 µM 0.567340454744397 0.358106464223741 no 1178 0.285241448411674 308 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_742 0kpi-0133 140 µM 0.567271338206579 0.358126765908438 no 1179 0.285264923446541 318 2728852 SGTC_2836 9010338 19.48 µM 0.567036748797566 0.358195675131979 no 1180 0.285344607254361 296 2994051 SGTC_1473 k844-0725 134 µM 0.566473136756719 0.358361251645695 no 1181 0.285536094656101 312 54682906 SGTC_1297 1068-0111 14.1 µM 0.566279021304139 0.358418284558318 no 1182 0.285602059612194 313 767057 SGTC_55 0767-0285 6.563 µM 0.565993519507341 0.358502173361258 no 1183 0.285699092953936 328 3116166 SGTC_3313 9133968 57.047 µM 0.56576201537536 0.358570201079888 no 1184 0.285777785651553 302 1494643 SGTC_629 3448-6466 76.7 µM 0.56153337661071 0.359813578446807 no 1185 0.287216991881012 326 573744 SGTC_1867 st057372 64 µM 0.56033786246327 0.360165374008776 no 1186 0.287624503180902 304 688837 SGTC_479 n-linoleoylglycine 10 µM 0.559252514056691 0.36048485446279 no 1187 0.287994699120955 328 6433346 An anti-infammatory. SGTC_1263 0774-1208 64.8 µM 0.559010441164686 0.360556123731753 no 1188 0.288077297193705 342 906585 SGTC_2909 7941780 10.49 µM 0.558893436927559 0.36059057297054 no 1189 0.288117224401064 313 1243215 SGTC_1340 1486-1359 257 µM 0.557748177319457 0.360927828337418 no 1190 0.288508177260886 312 4309068 SGTC_1316 1272-0050 65.9 µM 0.554714194179875 0.361821796081109 no 1191 0.289545082929725 320 7340392 SGTC_1886 st057356 49.9 µM 0.552482723611279 0.362479784169233 no 1192 0.290308833907698 320 24207747 SGTC_3296 9122258 64.045 µM 0.551652702963829 0.362724634066861 no 1193 0.290593160242228 318 4730474 SGTC_886 0866-0150 153 µM 0.549807885581721 0.36326904236672 no 1194 0.291225574728046 325 271463 SGTC_741 4582-0002 126 µM 0.547823007511178 0.363855091368393 no 1195 0.291906719533958 338 2912688 SGTC_2902 5787006 60.46 µM 0.547432276859442 0.363970494877609 no 1196 0.29204089278693 313 591003 SGTC_1616 st002734 56.1 µM 0.547073617682557 0.364076436838494 no 1197 0.292164078260947 326 4026101 SGTC_3172 9105863 49.47 µM 0.546391933183891 0.364277823742555 no 1198 0.2923982769909 315 2348785 SGTC_2402 5553605 200 µM 0.54569757908436 0.364482992097227 no 1199 0.292636918168566 318 6758546 SGTC_1960 st011366 51.8 µM 0.545694129180193 0.364484011574905 no 1200 0.292638104085118 322 3972846 SGTC_3138 9097216 49.47 µM 0.54463468425487 0.36479713238398 no 1201 0.293002397531177 323 25237486 SGTC_1156 4092-0367 4.88 µM 0.544344317456442 0.364882966559263 no 1202 0.29310227778453 329 1357585 SGTC_289 k017-0060 526 µM 0.544176185921255 0.364932670350336 no 1203 0.293160118819755 325 5512909 SGTC_1733 st037357 54.9 µM 0.542303047072904 0.365486569305729 no 1204 0.293804878432883 328 1272339 YGL099W LSG1 SGTC_1832 st054113 55 µM 0.54181568722377 0.365630730737642 no 1205 0.293972741746899 311 1251267 SGTC_1429 4049-0205 9.46 µM 0.541330632768015 0.365774229078964 no 1206 0.294139855022685 310 22774478 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.540444135533121 0.366036538634101 no 1207 0.294445388657103 347 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3294 9122953 26.2835 µM 0.538569044939643 0.366591573608056 no 1208 0.295092125796721 319 16459826 SGTC_274 sirtinol 40.1 µM 0.538237284403341 0.366689805262809 no 1209 0.295206621341516 302 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3071 9117417 49.47 µM 0.537949716610872 0.366774958862738 no 1210 0.295305881849617 324 45595590 YGL055W OLE1 SGTC_858 0438-0351 2.77 µM 0.537792002934187 0.366821663286412 no 1211 0.295360326802442 302 2799119 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.537657498293397 0.366861496277035 no 1212 0.295406763322275 311 688803 SGTC_2842 9000675 19.48 µM 0.535520396801912 0.367494582087422 no 1213 0.296145028610148 316 2989072 SGTC_2798 7813637 45.45 µM 0.532821850226126 0.36829450254714 no 1214 0.297078453460972 340 956368 SGTC_333 3486-0131 40.1 µM 0.532716559995782 0.368325724953091 no 1215 0.297114900513402 325 6744690 SGTC_658 3253-0951 102 µM 0.531194638197658 0.368777127485926 no 1216 0.297641954072738 329 1184878 SGTC_1898 st060199 18.6 µM 0.527520737989383 0.369867552736534 no 1217 0.298916009554981 312 688866 SGTC_536 3852-0578 10.6 µM 0.524647498374011 0.370721069596055 no 1218 0.299914130470007 337 2869208 SGTC_1181 1222-0449 220 µM 0.52346585621687 0.371072270029905 no 1219 0.300325052764727 321 658318 SGTC_1430 4049-0248 69.1 µM 0.521705453877467 0.371595685144317 no 1220 0.300937713389976 336 22774488 SGTC_387 norethindrone acetate 66.7 µM 0.521581251250259 0.371632622916612 no 1221 0.300980960045221 339 541197 SGTC_873 0591-4978 488 µM 0.517798653431039 0.372758129442811 no 1222 0.302299378971683 341 3305145 SGTC_1908 st060353 56.5 µM 0.517347033053473 0.372892581271756 no 1223 0.302456963592788 348 4227716 SGTC_2769 toremifene 3.73 µM 0.514590092403514 0.373713684856731 no 1224 0.303419744946801 314 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2377 9073351 62.6 µM 0.511753702685385 0.374559049470503 no 1225 0.304411698037035 359 7337946 YHR072W ERG7 SGTC_1964 st076914 61 µM 0.510604343500052 0.374901779324766 no 1226 0.304814066911161 362 24208661 SGTC_1603 st002045 67.8 µM 0.510233598442852 0.375012353671732 no 1227 0.304943908134964 359 5887985 SGTC_3134 9127454 49.47 µM 0.506187297498863 0.376219825066599 no 1228 0.306362585703154 354 24262820 SGTC_1518 st038567 90.8 µM 0.505967750516815 0.376285375667045 no 1229 0.306439644635633 354 77966 SGTC_2624 nerol 100 µM 0.505888431065042 0.376309059118888 no 1230 0.306467487124825 358 637566 A natural product oil. SGTC_65 0798-0905 34.986 µM 0.504400735376734 0.376753346178009 no 1231 0.306989900696483 369 3602145 SGTC_1087 pterostilbene 9.05 µM 0.504083858602978 0.376847999714751 no 1232 0.307101224631933 353 5281727 Similar to reservatol, lowers cholesterol. SGTC_1014 4130-3005 69.3 µM 0.50339847688486 0.37705275383547 no 1233 0.307342071133096 341 743608 SGTC_1609 st001574 46.4 µM 0.502688929378369 0.377264763783574 no 1234 0.307591497168401 353 3960012 SGTC_89 0302-0250 142.109 µM 0.50162322599292 0.377583261179074 no 1235 0.307966289235402 342 4203518 YLR208W SEC13 SGTC_3208 9114115 49.47 µM 0.500362960217394 0.377960013161451 no 1236 0.308409764615834 354 650895 SGTC_2023 5144124 124 µM 0.499602036869764 0.378187544732823 no 1237 0.308677661682255 341 2830192 SGTC_3028 9087778 49.47 µM 0.499346627145579 0.378263926915028 no 1238 0.308767606215026 332 17217395 SGTC_213 1246-0773 967 nM 0.499265289923535 0.378288252416632 no 1239 0.308796252162794 349 6251622 SGTC_1165 k072-0275 30.3 µM 0.498344715584167 0.378563601948522 no 1240 0.309120547936788 335 6153523 YGL055W OLE1 SGTC_544 k015-0020 52.4 µM 0.497144927471389 0.378922558600019 no 1241 0.30954342720294 332 3008304 SGTC_31 0508-1974 57.237 µM 0.496423858169488 0.379138340815966 no 1242 0.30979769787453 322 6810525 SGTC_1784 st039334 36.3 µM 0.495762076447461 0.379336414190138 no 1243 0.310031142083185 357 3496984 SGTC_531 3788-1495 174 µM 0.495674547415731 0.379362614280784 no 1244 0.310062023780042 343 2896655 SGTC_3119 9125183 49.47 µM 0.495239813686525 0.379492751462484 no 1245 0.310215424913663 317 22695334 SGTC_2937 9044753 11.33 µM 0.495225741762288 0.379496964109554 no 1246 0.310220390916897 331 6465530 YGL099W LSG1 SGTC_1480 1070-0044 41.2 µM 0.494394366590647 0.379745874434026 no 1247 0.310513845860469 328 3124987 SGTC_1021 4476-0760 85.3 µM 0.494101049578663 0.379833704245219 no 1248 0.310617408334239 331 746768 SGTC_3163 9099914 49.47 µM 0.493589481949145 0.379986901082945 no 1249 0.310798065239242 368 16268368 SGTC_2369 9071472 200 µM 0.493360152543716 0.380055583435179 no 1250 0.31087906629504 343 17296037 SGTC_215 1287-0124 461.5 µM 0.493109457628088 0.380130668917481 no 1251 0.310967624312576 353 5560863 SGTC_826 1683-5028 118 µM 0.492983737020921 0.380168325121499 no 1252 0.311012039258565 345 722377 SGTC_1108 betulinic acid 729.144 nM 0.491963273692659 0.380474019281946 no 1253 0.31137265335576 309 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2361 9034121 116 µM 0.491479137996649 0.380619075070563 no 1254 0.311543801893008 359 6496917 SGTC_1515 3460-0031 42.1 µM 0.491347420460315 0.380658542926086 no 1255 0.311590372878312 327 2876596 SGTC_1417 3966-0327 90.4 µM 0.489740846853399 0.381140036649453 no 1256 0.312158646827462 349 651118 SGTC_1738 st035555 74 µM 0.486485405169593 0.382116263539445 no 1257 0.313311525351071 376 5331140 SGTC_881 0833-0569 170 µM 0.485049192785969 0.382547187088321 no 1258 0.313820725472363 329 5418700 SGTC_3295 9122362 53.5725 µM 0.48409971723322 0.382832149219922 no 1259 0.314157550981511 354 4730473 SGTC_2301 7769476 200 µM 0.481938150929959 0.383481127457483 no 1260 0.314924941675054 341 977820 SGTC_2618 avocadyne 43.43 µM 0.481547309376401 0.383598506806055 no 1261 0.315063782159034 347 3015189 SGTC_2159 5658611 73.75 µM 0.480505833246405 0.383911339883911 no 1262 0.31543387818162 360 793844 SGTC_2424 5537928 59.2 µM 0.479364741109272 0.384254181950436 no 1263 0.315839586138571 341 5382802 SGTC_2034 5197015 53.07 µM 0.477448886040148 0.384830005755645 no 1264 0.316521255083824 367 780676 SGTC_474 dl-dihydrosphingosine 5 µM 0.477391477708083 0.384847264164056 no 1265 0.316541690835547 313 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3317 9138495 8.753 µM 0.477135648266838 0.384924175790643 no 1266 0.316632765730339 342 17020139 SGTC_2556 citropten 84.59 µM 0.476756527551411 0.385038161581041 no 1267 0.316767752576995 303 2775 A potential DNA crosslinker. SGTC_656 4090-1979 187 µM 0.476122157859724 0.38522891231066 no 1268 0.316993676004296 355 22330961 SGTC_1352 1496-0991 99 µM 0.475286083231342 0.385480356783528 no 1269 0.317291538547778 381 3000039 SGTC_1135 dihydrocapsaicin 536.708 nM 0.474833122306206 0.385616602201105 no 1270 0.317452961267239 381 107982 A Capsaicinoid. SGTC_1820 st053765 18.6 µM 0.474659250091327 0.385668904706044 no 1271 0.317514933729378 338 3690829 SGTC_497 capsazepine 133 µM 0.4727168747703 0.386253331794849 no 1272 0.318207592892437 329 2733484 A calcium channel blocker. SGTC_963 1269-2853 151 µM 0.472489316544612 0.386321817043122 no 1273 0.318288782785101 317 3668223 SGTC_1460 k062-0059 9.15 µM 0.472443684469547 0.386335550763388 no 1274 0.318305064782436 325 1373085 SGTC_2754 granisetron 64.02 µM 0.472309778486416 0.386375852783861 no 1275 0.318352845851352 370 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2555 cholic acid 100 µM 0.472071354240324 0.386447614962933 no 1276 0.318437929181667 342 6708657 Influences liver metabolism. SGTC_262 fenpropimorph 62.5 µM 0.470485991856967 0.38692488430443 no 1277 0.319003920016223 363 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_337 1315-0038 354 µM 0.469990597439827 0.387074056648716 no 1278 0.319180867622593 372 1626437 SGTC_1327 1436-0082 2.18 µM 0.469117555794561 0.387336986087132 no 1279 0.319492805539873 348 15992205 SGTC_3112 9123419 49.47 µM 0.468988053222689 0.387375992112407 no 1280 0.319539087716851 353 17015854 SGTC_666 0272-0154 136 µM 0.468731420106248 0.387453293069865 no 1281 0.319630812649943 345 6870312 SGTC_1131 3454-3128 32.3 µM 0.467278134118342 0.387891124251511 no 1282 0.320150449203835 319 710982 SGTC_1273 0849-0096 14.1 µM 0.467033424177691 0.387964862005654 no 1283 0.320237982372965 364 5286025 SGTC_260 nsc-65238 3.989 µM 0.466910447262617 0.388001919816946 no 1284 0.32028197520566 336 3246252 SGTC_1765 st044815 90.4 µM 0.466199552679073 0.388216160467769 no 1285 0.320536334756378 352 645695 SGTC_2652 actinonin 100 µM 0.465273311851013 0.388495350547833 no 1286 0.320867872115662 339 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_401 neomycin 50 µM 0.464578692413847 0.388704762480286 no 1287 0.321116597019157 334 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2972 9093619 59.92 µM 0.464032399007467 0.388869480220761 no 1288 0.321312266681841 319 25236256 SGTC_415 dibenzyl ketone 100 µM 0.463566908343509 0.38900985018045 no 1289 0.321479033817303 386 7593 SGTC_1782 st039423 80.636 µM 0.462591811043171 0.389303940333944 no 1290 0.32182848974413 347 2068169 SGTC_2154 5570129 200 µM 0.462442332156791 0.389349028899996 no 1291 0.321882074016546 371 673366 SGTC_2663 amphotericin b 100 µM 0.462276090292381 0.389399175572941 no 1292 0.321941671728794 351 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_808 0711-0032 135 µM 0.460228385202274 0.390017014353491 no 1293 0.322676149324716 372 4252555 SGTC_1032 k061-1018 98.7 µM 0.459852662498242 0.390130408586878 no 1294 0.322810990040993 360 4005393 SGTC_2826 7992541 19.48 µM 0.459779831401239 0.390152390311393 no 1295 0.322837130623623 391 2985066 SGTC_3247 9135149 49.47 µM 0.459662393622233 0.390187835868164 no 1296 0.322879283307997 374 8934436 YOR116C RPO31 SGTC_2016 5121758 140 µM 0.45881900120328 0.390442418864751 no 1297 0.323182074304483 349 2795203 SGTC_744 1594-0068 283 µM 0.458625083881204 0.390500960603733 no 1298 0.32325171021589 353 668392 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.457465427455651 0.390851101282282 no 1299 0.323668273232172 356 688751 SGTC_2521 angolensin 13.4 µM 0.457052190175428 0.390975893418601 no 1300 0.323816766646368 359 821428 A flavenoid. SGTC_144 4161-2749 112.381 µM 0.45591238902486 0.391320156287465 no 1301 0.324226490121163 357 797501 YMR168C CEP3 SGTC_1897 st060201 15 µM 0.453468619895808 0.392058553280869 no 1302 0.325105667253769 344 611878 SGTC_1353 1498-1206 8.11 µM 0.452407141240244 0.392379405642895 no 1303 0.32548785166376 347 6756808 SGTC_414 piperonyl butoxide 100 µM 0.449354958961419 0.393302393485357 no 1304 0.326587808713004 364 5794 A potent inhibitor of cytochrome P450. SGTC_1134 3477-0009 42.5 µM 0.448761789872182 0.393481839152887 no 1305 0.326801752701269 400 3973534 SGTC_126 0417-1624 672.48 µM 0.447071423035026 0.393993333368187 no 1306 0.327411745758934 395 41912 YDL195W SEC31 SGTC_3092 9117248 49.47 µM 0.446833824229475 0.394065243932168 no 1307 0.327497523684993 376 17141857 SGTC_2293 7624732 200 µM 0.44124572090142 0.395757549958669 no 1308 0.32951755839552 359 894453 SGTC_166 k072-0058 166.424 µM 0.440756432165758 0.395905820695659 no 1309 0.329694668794414 369 5846229 SGTC_597 k018-0003 82.8 µM 0.440553171496665 0.395967419858664 no 1310 0.329768255352748 381 6786234 SGTC_1531 st059297 52.4 µM 0.440341848370937 0.39603146514412 no 1311 0.329844767753148 351 7566702 SGTC_1339 1486-1321 22.7 µM 0.440132059055988 0.396095048356636 no 1312 0.329920731859401 369 3469382 SGTC_3077 9117319 49.47 µM 0.438455961166777 0.396603141371597 no 1313 0.330527893739595 367 17154678 SGTC_2090 5301565 104.445 µM 0.436594070750162 0.397167761486561 no 1314 0.331202881719926 362 2056344 SGTC_2002 4023503 131 µM 0.43507360602631 0.397629003891194 no 1315 0.331754500464712 399 4736863 YCR052W RSC6 SGTC_309 k408-0051 1.48 µM 0.434377045669891 0.397840357648515 no 1316 0.332007331859331 374 3640463 SGTC_94 0334-0113 514.748 µM 0.433804751880608 0.398014028277236 no 1317 0.332215115319111 352 6795178 SGTC_1721 st082152 9.2685 µM 0.432475871766397 0.398417373595054 no 1318 0.332697792462175 360 5296051 SGTC_3141 9094609 49.47 µM 0.43191306224456 0.398588231823103 no 1319 0.3329023003756 385 25236309 YDL196W YDL196W SGTC_1347 1493-0251 600 nM 0.430522609193485 0.399010430103523 no 1320 0.333407761888741 345 3986378 SGTC_524 r073-0010 27.8 µM 0.429826578172881 0.399221817937432 no 1321 0.333660898824153 381 2772106 SGTC_916 4466-0038 42 nM 0.42970491219763 0.399258771492009 no 1322 0.333705154850484 366 5722064 YGL116W CDC20 SGTC_2364 9055074 200 µM 0.429165879959211 0.399422502378055 no 1323 0.333901255776995 356 6470630 SGTC_76 0433-0009 400.328 µM 0.42747764860212 0.399935416512837 no 1324 0.334515730828552 398 2841569 SGTC_986 1493-0483 84 µM 0.426599615568348 0.40020224658356 no 1325 0.334835488892825 383 40079 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.42577275195638 0.400453569112386 no 1326 0.335136721839383 353 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3118 9124250 49.47 µM 0.425619559081292 0.400500136121897 no 1327 0.335192542865277 390 1504786 SGTC_510 ag-490 170 µM 0.424893351867967 0.400720905165695 no 1328 0.335457210628105 351 5328779 SGTC_2889 9059656 51.95 µM 0.423599984237802 0.40111417107588 no 1329 0.335928783410528 367 3949838 SGTC_2936 9038235 15.59 µM 0.422916088091308 0.401322159473796 no 1330 0.336178242228089 349 4749415 SGTC_1775 st081588 35.1725 µM 0.422657893039943 0.401400689745524 no 1331 0.336272440549043 363 1426443 YGL099W LSG1 SGTC_2575 plumbagin 510 nM 0.419408826873938 0.402389235722041 no 1332 0.33745868712125 353 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1000 4048-0884 8.67 µM 0.419148059862245 0.402468602655594 no 1333 0.337553964421627 374 13040088 SGTC_1957 st077035 62.4 µM 0.418667409271325 0.402614903791505 no 1334 0.337729608593488 369 705593 SGTC_2443 5493264 126.67 µM 0.417538435987596 0.402958595953438 no 1335 0.33814230832914 383 5340055 SGTC_2711 st079103 59.1 µM 0.417515712519714 0.402965514405895 no 1336 0.338150616963478 390 54693780 SGTC_1840 st055363 71 µM 0.416231231946909 0.403356640391008 no 1337 0.338620403942662 365 676033 SGTC_100 0086-0128 49.5915 µM 0.415260187306418 0.403652388933598 no 1338 0.338975721397095 384 93297 SGTC_2662 daunorubicin 22.37 µM 0.414779721847328 0.403798743436352 no 1339 0.339151582767756 350 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2104 5389443 200 µM 0.413850294741844 0.404081894284189 no 1340 0.339491873842875 379 2244536 SGTC_547 1120-0019 610 nM 0.413200386461511 0.404279919327117 no 1341 0.33972990250471 355 3676939 SGTC_1356 1502-0781 85.8 µM 0.412904910186044 0.404369958147911 no 1342 0.339838141723472 361 567702 SGTC_2247 cerulenin 830 nM 0.411645439910986 0.404753806184575 no 1343 0.340299660388265 343 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2655 perillic acid 100 µM 0.410798867529998 0.405011867108532 no 1344 0.340610011823132 371 5702197 An apoptosis inducer. SGTC_2626 ethyl orsellinate 100 µM 0.408199351897842 0.405804535997473 no 1345 0.341563661971451 368 75653 A natural product. SGTC_2705 st078069 42.8 µM 0.407953767425251 0.405879441962632 no 1346 0.341653808748439 366 1530061 SGTC_2737 bleomycin 30.5 nM 0.407570489388527 0.405996352864176 no 1347 0.341794516795464 376 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2721 ifenprodil 61.44 µM 0.406166104554418 0.406424802473889 no 1348 0.342310278650694 367 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1437 4092-1038 11.6 µM 0.405567919915997 0.406607330654894 no 1349 0.342530052026341 374 3977136 SGTC_148 3253-0744 288.01 µM 0.404772575437079 0.40685005099192 no 1350 0.342822344612381 362 6893655 SGTC_653 0203-0016 55.2 µM 0.402749283943545 0.407467672836454 no 1351 0.343566336995013 389 295302 SGTC_3299 9121982 43.1275 µM 0.401516004578352 0.40784425171883 no 1352 0.344020128627285 358 17594604 YPL160W CDC60 SGTC_711 k292-0785 179 µM 0.400997080679645 0.408002729354703 no 1353 0.344211136623596 358 4146315 SGTC_2822 7994718 71.43 µM 0.400590649413012 0.408126862626663 no 1354 0.344360765553537 401 1018011 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.39425087061356 0.410064360220763 no 1355 0.346697915708196 389 23665772 A membrane-active detergent. SGTC_1525 8-methoxypsoralen 92.5 µM 0.394185519213165 0.410084343763895 no 1356 0.346722037999009 424 4114 Related to psoralen; DNA damaging agent. SGTC_489 paxilline 115 µM 0.393535779044116 0.410283037903344 no 1357 0.346961901709603 371 105008 A toxic potassium channel blocker. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.391988370598998 0.410756336627767 no 1358 0.347533403261337 353 16623 A steroid. SGTC_2360 9040895 200 µM 0.3918293072849 0.410804995972593 no 1359 0.347592169500241 345 4914414 SGTC_2569 tetrandrine 100 µM 0.390057754918765 0.41134702736108 no 1360 0.348246920112155 343 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1372 2752-0194 270 µM 0.389899375823411 0.411395493932935 no 1361 0.348305477737738 363 823334 SGTC_3325 9138760 55.175 µM 0.389827047981334 0.411417627875467 no 1362 0.348332220769662 346 43844959 SGTC_911 3456-4043 236 µM 0.389109937547834 0.411637095002472 no 1363 0.348597411272287 377 914281 SGTC_1663 st014140 55.4 µM 0.389078026585803 0.411646861794251 no 1364 0.348609213803186 376 4207120 SGTC_2683 piperine 63.03 µM 0.388738747311831 0.411750706297809 no 1365 0.348734708083364 396 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1335 1486-0900 202 µM 0.386982653799433 0.412288299187844 no 1366 0.349384524847595 372 X1335 SGTC_395 anisomycin 6.25 µM 0.386873151375618 0.412321826626541 no 1367 0.349425059270029 392 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2050 5263056 171 µM 0.386782106799467 0.412349703130878 no 1368 0.349458762473576 372 763468 YGL055W OLE1 SGTC_2617 dihydrotanshinone i 20.83 µM 0.385970356599349 0.412598268582575 no 1369 0.349759311474325 357 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1242 0402-0103 60.1 µM 0.385293787570385 0.412805467092845 no 1370 0.350009881865522 366 432868 SGTC_997 3996-0078 137 µM 0.382766881956396 0.413579543497132 no 1371 0.350946309593703 375 735687 SGTC_1155 4088-0394 48.2 µM 0.38252097774489 0.413654890236559 no 1372 0.351037485926272 378 2326248 SGTC_1354 1498-1681 81 µM 0.38212217437459 0.41377709308642 no 1373 0.351185372421668 372 5754243 SGTC_2818 7996756 12.99 µM 0.381760457087281 0.413887939099559 no 1374 0.35131952594092 396 2241621 SGTC_1630 st005209 31.3 µM 0.381633705897174 0.413926782837319 no 1375 0.351366539740516 395 3367314 SGTC_117 lucigenin 22.078 µM 0.380967278733769 0.414131027679888 no 1376 0.351613764349045 395 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2473 5854593 8.94 µM 0.380262126738168 0.414347166096037 no 1377 0.351875423066442 386 2872951 SGTC_191 3914-0123 66.505 µM 0.38011377694066 0.414392640576607 no 1378 0.351930479735893 396 3144412 SGTC_1933 st074711 15.9 µM 0.379720821253197 0.414513100992009 no 1379 0.35207633134592 363 17250958 SGTC_964 1287-0107 19.4 µM 0.3794747004662 0.414588553320818 no 1380 0.35216769398701 384 51516812 YPR165W RHO1 SGTC_2495 cafestol 54.53 µM 0.378701056067157 0.414825747100145 no 1381 0.352454934523498 389 16667697 An anti-infammatory. SGTC_2922 7999257 32.47 µM 0.378205079461054 0.414977826283714 no 1382 0.352639126185401 376 2988377 SGTC_1977 st070720 65.3 µM 0.377283555090154 0.415260423170513 no 1383 0.35298144594697 361 682188 SGTC_159 3970-0959 50 µM 0.374198047801923 0.416206950645694 no 1384 0.354128488150352 390 6615653 SGTC_2962 9082311 13.18 µM 0.373888791998874 0.416301846582562 no 1385 0.35424352770232 387 16459453 SGTC_45 0kpi-0036 14.9 µM 0.373400643620836 0.416451646092027 no 1386 0.354425140272655 406 2795021 SGTC_890 0929-0006 47.2 µM 0.371963541756395 0.416892724084431 no 1387 0.35495999714995 364 1378169 SGTC_499 genistein 192 µM 0.370303366592403 0.417402398379822 no 1388 0.355578232829732 406 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_767 0929-0023 86 µM 0.367897581599057 0.41814122123461 no 1389 0.35647480178695 385 1204563 SGTC_1986 st071812 45 µM 0.36783049071667 0.418161829173231 no 1390 0.356499816086563 395 11838594 SGTC_1462 k081-0014 26.5 µM 0.366981570723844 0.41842260666358 no 1391 0.356816382415596 362 3270634 SGTC_2553 4-methylesculetin 85.09 µM 0.36547103454643 0.418886712885095 no 1392 0.357379912366296 375 5319502 SGTC_1471 k673-0312 37 µM 0.36491347138564 0.419058050508704 no 1393 0.357587999011111 377 24099884 SGTC_2244 6635614 200 µM 0.363506117634329 0.419490594650448 no 1394 0.35811342190784 382 836499 SGTC_3057 9095946 49.47 µM 0.361481020271758 0.420113170255973 no 1395 0.358869945397564 389 24540043 SGTC_3203 9113543 49.47 µM 0.361213721884825 0.420195360760064 no 1396 0.358969842541036 383 17018012 SGTC_1629 st005085 44.9 µM 0.361076181166208 0.420237653957833 no 1397 0.359021249247339 408 24207091 SGTC_2194 5927483 104.545 µM 0.359425853680646 0.420745194469097 no 1398 0.359638268355913 331 760979 SGTC_1557 sumaresinolic acid 42.3 µM 0.358334174737092 0.421081001080506 no 1399 0.360046623030229 382 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_914 3820-6779 408 µM 0.358127419350864 0.421144606680402 no 1400 0.360123980194849 356 2893481 SGTC_1492 4158-0558 28.5 µM 0.357987168277308 0.42118775426694 no 1401 0.360176458148567 379 3967268 SGTC_2056 5235370 200 µM 0.357217921524114 0.421424426250851 no 1402 0.360464335189765 367 5511916 SGTC_293 4049-0273 38.5 µM 0.356100130638588 0.421768384406447 no 1403 0.360882789698712 378 1380311 SGTC_1274 0865-0114 173 µM 0.356049565742411 0.42178394526693 no 1404 0.360901723038956 367 870624 SGTC_2785 7756463 72.73 µM 0.355814136882489 0.421856397841981 no 1405 0.360989880673196 409 2201551 SGTC_1728 st035614 33.7865 µM 0.355231004525132 0.422035866583271 no 1406 0.361208269589687 393 15945546 SGTC_2440 5628896 157.78 µM 0.354998969639327 0.422107283707541 no 1407 0.361295181568439 391 5522048 SGTC_3200 9114385 49.47 µM 0.354890525355577 0.422140662234588 no 1408 0.361335803378125 357 17018030 YLR208W SEC13 SGTC_2217 6934799 96.0675 µM 0.353093582103015 0.4226938322684 no 1409 0.362009142076352 388 675606 SGTC_2593 nobiletin 86.24 µM 0.352864357563932 0.422764407614712 no 1410 0.362095066355337 345 72344 An anti-infammatory. SGTC_270 tamoxifen 5.46 µM 0.351199687961039 0.42327701264082 no 1411 0.362719272103809 414 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1530 rhein 70.4 µM 0.349653866274087 0.423753136931494 no 1412 0.363299240028972 393 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2862 9027634 71.43 µM 0.348882788251364 0.423990676216989 no 1413 0.363588653635103 355 5012562 SGTC_736 0958-0254 92.6 µM 0.34683792526482 0.424620752849299 no 1414 0.364356541694658 420 6812352 SGTC_364 0083-0097 67.7 µM 0.345580964119257 0.425008151699095 no 1415 0.364828826977933 372 5207356 SGTC_888 0916-0002 6.97 µM 0.344737678033248 0.425268095389415 no 1416 0.365145794789911 378 2802138 YIL048W NEO1 SGTC_2134 5324836 1.464 µM 0.344509698161411 0.425338375972835 no 1417 0.365231501923852 404 699272 SGTC_3030 9087619 49.47 µM 0.341912684673169 0.426139138230598 no 1418 0.366208301670423 401 25236973 SGTC_2343 7990716 14.84 µM 0.340329579239437 0.426627422087327 no 1419 0.36680417208761 387 6456862 SGTC_1847 st056231 15 µM 0.33923904345492 0.426963846089084 no 1420 0.367214829423338 375 5393180 SGTC_2329 6138490 200 µM 0.339223030516186 0.426968786384765 no 1421 0.367220860464653 409 720019 SGTC_3135 9127742 49.47 µM 0.338980625138084 0.427043574445931 no 1422 0.367312162938282 390 3643468 SGTC_3026 9090633 49.47 µM 0.338891160372692 0.427071177203911 no 1423 0.367345861918011 377 25236842 SGTC_2326 6164455 177.58 µM 0.337653566814429 0.427453051204507 no 1424 0.367812134968842 406 2888790 SGTC_1942 st076330 65.2 µM 0.337025077797491 0.427647004908032 no 1425 0.368048997774837 413 24208414 SGTC_1065 prochlorperazine maleate 2.48 µM 0.337008237547336 0.427652202103381 no 1426 0.368055345161738 422 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1459 k035-0031 35.7 µM 0.33536027986683 0.428160851213159 no 1427 0.368676663435863 382 3877128 YMR208W ERG12 SGTC_2318 6029776 164 µM 0.334658468059095 0.428377504693141 no 1428 0.368941367138237 408 818325 SGTC_32 0928-0142 34.1 µM 0.334559467162513 0.428408068597849 no 1429 0.36897871250267 418 2244242 SGTC_2381 9035592 200 µM 0.334415436208796 0.428452535106824 no 1430 0.369033046426016 395 4749657 SGTC_2165 5727197 32.143 µM 0.332883720417357 0.428925476029151 no 1431 0.369611029264907 417 1361712 SGTC_169 k015-0017 16.025 µM 0.332614705844387 0.429008548992003 no 1432 0.369712570604017 416 1840002 SGTC_1080 nisoldipine 24.4 µM 0.332284291005322 0.429110586948131 no 1433 0.369837300314665 429 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1904 st060225 78 µM 0.332153047798932 0.4291511184904 no 1434 0.369886847674836 394 66595 SGTC_186 3455-3465 67.277 µM 0.331038204986022 0.429495442953706 no 1435 0.370307813767299 418 755278 SGTC_2362 9071156 126 µM 0.330487477443651 0.429665557565771 no 1436 0.370515826571274 383 653133 SGTC_2992 9074591 71.4286 µM 0.329095245788142 0.430095663136544 no 1437 0.371041848799039 382 17741321 SGTC_3354 9151612 71.43 µM 0.327290068838917 0.430653464371712 no 1438 0.371724251554631 423 27261949 SGTC_961 1252-1571 372 µM 0.327239849358898 0.430668984217965 no 1439 0.371743241569154 421 6813498 SGTC_774 k060-0086 136 µM 0.325253028027671 0.431283077878752 no 1440 0.372494788960916 419 5911235 SGTC_511 blebbistatin 171 µM 0.324459877211092 0.431528274182032 no 1441 0.372794946952408 409 3476986 A myosin inhibitor. SGTC_3303 9125618 40.5795 µM 0.323801518461666 0.431731820628429 no 1442 0.373044153258176 410 22695467 SGTC_2307 7538926 6.34 µM 0.322584665845937 0.432108085717265 no 1443 0.373504904137593 387 96582 SGTC_2061 5245884 80.95 µM 0.322251873129773 0.432210999864709 no 1444 0.373630944792712 418 573863 SGTC_1745 st081495 74 µM 0.321938404566968 0.43230794234096 no 1445 0.37374967905438 392 13842402 YBL026W LSM2 SGTC_3255 9139072 49.47 µM 0.32055689848481 0.432735231817728 no 1446 0.374273102568918 385 17646060 SGTC_2821 7996764 71.43 µM 0.318760725915904 0.433290892088155 no 1447 0.374953981015295 353 2987135 SGTC_1789 tunicamycin 25 nM 0.31536634180073 0.434341331105667 no 1448 0.376241759627415 419 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2484 5809818 12.04 µM 0.315155485803165 0.434406598779466 no 1449 0.376321800880693 390 2870548 SGTC_2171 5739187 198.077 µM 0.315140880907352 0.434411119597234 no 1450 0.376327345118082 375 2262761 SGTC_3248 9135562 49.47 µM 0.314557823711802 0.434591606852841 no 1451 0.37654870320296 377 17650701 SGTC_2695 st077686 51.995 µM 0.313148735137015 0.435027851028135 no 1452 0.37708383219541 372 2876092 SGTC_2566 crystal violet carbinol 226 nM 0.312981441966168 0.435079649111803 no 1453 0.377147380757965 445 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1623 st003709 20.3 µM 0.31240165671163 0.435259173514026 no 1454 0.377367645729089 375 16192618 SGTC_1627 st003713 25.6 µM 0.312139243575071 0.435340431369167 no 1455 0.377467351660334 393 16195070 YER133W GLC7 SGTC_1724 st037281 8.293 µM 0.311703082908531 0.435475497263522 no 1456 0.377633092395373 385 574124 YDL195W SEC31 SGTC_1361 1608-0041 5.61 µM 0.311256080278141 0.435613928399827 no 1457 0.377802976450134 412 X1361 SGTC_2012 4023501 200 µM 0.311014085929217 0.435688874322663 no 1458 0.37789495664852 427 3477460 SGTC_2113 5491891 107.031 µM 0.309877631681704 0.43604086633476 no 1459 0.378327006719973 403 789979 SGTC_480 am 92016 50 µM 0.30820503895398 0.436559007671484 no 1460 0.378963159224091 427 2129 K+ channel blocker. SGTC_2115 tiliquinol 12.7705 µM 0.306478961552861 0.437093831808817 no 1461 0.379619997949201 427 71208 A bioactive hydroxyquinoline. SGTC_1284 0929-0043 16 µM 0.305257095703561 0.437472495837876 no 1462 0.380085175023956 417 1239883 SGTC_3062 9077494 49.47 µM 0.303433401854878 0.43803777664828 no 1463 0.380779796901384 377 16459633 SGTC_1754 st042065 16.137 µM 0.302817050981682 0.438228852343287 no 1464 0.381014644174609 416 1126236 YIL048W NEO1 SGTC_72 0744-0168 198.391 µM 0.302339491696057 0.438376910991259 no 1465 0.381196638037041 444 677577 SGTC_60 0986-0278 202 µM 0.30230268088221 0.438388323878846 no 1466 0.381210667422675 433 3110598 SGTC_443 clozapine 122 µM 0.301960663175576 0.438494366081102 no 1467 0.381341025121096 447 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_18 0111-0177 500 nM 0.30155181761681 0.438621133976772 no 1468 0.381496871461429 411 721752 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.300123771722201 0.439063967551309 no 1469 0.382041373660808 412 2724278 An inhibitor of dopamine biosynthesis. SGTC_2059 5238311 157 µM 0.299135493926919 0.439370474797432 no 1470 0.382418332612046 398 703021 SGTC_895 0964-0006 13.7 µM 0.29826006061292 0.439642014508691 no 1471 0.382752342379497 430 6738897 SGTC_2191 5911152 200 µM 0.297338032922384 0.439928037450947 no 1472 0.383104223908851 409 2875902 SGTC_1485 3909-9022 254 µM 0.2966384449968 0.440145078106075 no 1473 0.383371278186584 413 714516 SGTC_1304 1165-0502 251 µM 0.296014097315683 0.440338791365654 no 1474 0.383609657752235 388 767425 SGTC_2853 9015042 58.44 µM 0.296000995058683 0.44034285669112 no 1475 0.38361466074226 396 6457456 SGTC_1877 wortmannin 25 µM 0.294971643185788 0.440662260244922 no 1476 0.38400777094146 429 312145 A covalent inhibitor of PI 3-kinase. SGTC_1648 st011736 69.8 µM 0.294918960247299 0.44067860857934 no 1477 0.384027893806979 407 2855514 SGTC_17 0960-0276 49.807 µM 0.294722566437203 0.440739553521029 no 1478 0.384102911478246 405 6821114 SGTC_2421 5690543 90.72 µM 0.29431477107268 0.440866105090363 no 1479 0.384258693281082 429 3397993 SGTC_2083 5306046 65.942 µM 0.293547058716162 0.441104366459133 no 1480 0.384552017597897 390 539837 SGTC_1987 st072290 61.9 µM 0.2929454575525 0.441291089724269 no 1481 0.384781921056585 436 54697379 SGTC_830 4076-0286 57.8 µM 0.292498973393838 0.441429676651882 no 1482 0.384952572346175 404 6866659 SGTC_912 3474-0017 2.18 µM 0.292404240257877 0.441459082367661 no 1483 0.384988783288192 431 3360550 SGTC_1723 st034307 2.5525 µM 0.292250169962914 0.441506907371427 no 1484 0.385047677500778 404 867466 SGTC_3216 9129716 49.47 µM 0.288785151416944 0.442582708727628 no 1485 0.386372897838411 381 8056934 SGTC_2828 7998861 71.43 µM 0.288469201775777 0.442680824355666 no 1486 0.386493801189723 434 2988188 SGTC_968 1309-0633 340 µM 0.28704816042507 0.443122160732527 no 1487 0.387037722228898 431 3761976 SGTC_1164 k060-0068 93.7 µM 0.284734255790783 0.44384094667942 no 1488 0.387923872076845 400 5963676 SGTC_147 4466-0538 29.23 µM 0.282129379071387 0.444650340509943 no 1489 0.388922153314307 382 6742687 YHR072W ERG7 SGTC_2856 9022925 19.48 µM 0.280755431961352 0.445077350011476 no 1490 0.389448994664096 403 4944862 SGTC_2823 7987624 58.44 µM 0.28041065593137 0.445184513097058 no 1491 0.389581231305799 424 2239440 SGTC_668 1682-0499 62.6 µM 0.279155580224996 0.445574648774901 no 1492 0.390062715441613 420 682214 SGTC_2974 9094440 9.66 µM 0.278355980872978 0.445823228810538 no 1493 0.390369553417329 386 25236134 SGTC_1050 3232-1156 69.3 µM 0.278184249199541 0.445876619661273 no 1494 0.390435462585726 434 700529 SGTC_1534 6-azauridine 81.6 µM 0.278118694632282 0.44589700063412 no 1495 0.390460622706441 420 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1096 rimcazole 32.2 µM 0.277885685081379 0.445969444666024 no 1496 0.390550056471818 443 18528119 A dopamine reuptake inhibitor. SGTC_261 5-fluorouridine 15.376 µM 0.27703582154631 0.446233687477951 no 1497 0.390876300284605 396 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_834 0312-0008 75.7 µM 0.276605245438129 0.446367572965046 no 1498 0.391041618261858 420 6385573 YIL048W NEO1 SGTC_2457 5731572 11.68 µM 0.274809303928738 0.446926077761668 no 1499 0.391731374855929 444 2865357 SGTC_2704 st078022 71.1 µM 0.274456284814081 0.447035872632836 no 1500 0.391866996920556 433 54697681 SGTC_2756 carbadox 75.1 µM 0.274055951518434 0.447160387920257 no 1501 0.392020811937344 402 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2172 5754775 163.918 µM 0.272310511795429 0.447703331091705 no 1502 0.392691637142123 413 2263357 SGTC_1256 0570-0116 285 µM 0.27223618357077 0.447726454096907 no 1503 0.392720210816927 403 410638 SGTC_99 0109-0120 622.8 µM 0.271120865048795 0.448073443392496 no 1504 0.393149037193989 440 759414 SGTC_2294 7971431 200 µM 0.270654999266591 0.44821839174148 no 1505 0.393328195336611 448 5741572 SGTC_93 0109-0045 59.227 µM 0.269946850627997 0.448438736626093 no 1506 0.393600571527526 437 88733 SGTC_2565 isoliquiritigenin 100 µM 0.269710062279901 0.448512418355976 no 1507 0.393691659380928 380 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3306 9127676 59.7925 µM 0.268935579348955 0.44875342758105 no 1508 0.393989628446264 389 41905287 SGTC_2600 tangeritin 87.95 µM 0.268426451652713 0.44891187194465 no 1509 0.394185540445422 425 68077 A bioactive flavone. SGTC_483 fpl-64176 144 µM 0.267454122752212 0.449214490621014 no 1510 0.394559766318453 438 3423 SGTC_3044 9093193 49.47 µM 0.267021545959012 0.449349131337197 no 1511 0.394726285964484 448 25236277 SGTC_1770 st043884 66.3 µM 0.266595044282907 0.449481886866427 no 1512 0.394890485837458 454 670149 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.265812331401397 0.449725533582258 no 1513 0.395191872845481 447 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_24 0417-1663 219 µM 0.263001694615079 0.450600598012243 no 1514 0.39627463648529 431 4329390 SGTC_2855 9016525 58.44 µM 0.257777728401601 0.452227663984294 no 1515 0.398289226947705 429 43811474 SGTC_2328 6201408 200 µM 0.256353675904876 0.452671342323694 no 1516 0.398838877082488 425 2890418 SGTC_901 1112-0062 60.1 µM 0.252533226591099 0.453861933412152 no 1517 0.400314467510945 418 1908457 SGTC_759 3486-0358 89.3 µM 0.2508360427027 0.454390971381762 no 1518 0.400970437078507 450 875103 SGTC_2938 9059746 27.26 µM 0.250528193912723 0.454486941218289 no 1519 0.401089452064949 438 6471769 SGTC_1719 st032227 49.2 µM 0.250259803928493 0.454570612199643 no 1520 0.401193219684787 427 3125804 SGTC_1453 4237-0541 195 µM 0.250014569565943 0.454647066143622 no 1521 0.40128804074071 415 739892 SGTC_354 2783-3500 4.88 µM 0.249177426194808 0.454908065505794 no 1522 0.401611770051422 408 6740761 SGTC_2749 bexarotene 57.39 µM 0.244140283776593 0.456478921519621 no 1523 0.403561087177172 424 82146 An retinoic acid receptor inhibitor. SGTC_3301 9125354 19.7965 µM 0.242966514370372 0.456845065553784 no 1524 0.404015668964526 406 41905162 SGTC_925 2064-1272 59.6 µM 0.239913167368999 0.457797693324495 no 1525 0.405198786423386 442 6815817 SGTC_725 1497-0963 19 µM 0.237250475182657 0.458628637043799 no 1526 0.406231240179487 455 3549977 SGTC_187 1488-2104 32.728 µM 0.236579557534291 0.458838038313432 no 1527 0.40649149038218 444 2852859 SGTC_1334 1486-0610 236 µM 0.236191197000455 0.458959255415689 no 1528 0.406642155039795 423 3742339 SGTC_2419 paclitaxel 166.5 µM 0.235802775678417 0.459080495308393 no 1529 0.406792857104168 435 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1011 4112-3381 17.4 µM 0.235022658003171 0.459324008832737 no 1530 0.407095573579729 440 2877139 SGTC_1631 benzylvanillin 81.9 µM 0.234144492898628 0.459598146091239 no 1531 0.407436402731874 407 75506 SGTC_116 0155-0182 31.788 µM 0.233111609499878 0.459920606415421 no 1532 0.407837370072045 415 771486 SGTC_796 1234-0020 70.7 µM 0.231522376531948 0.460416807328414 no 1533 0.408454501827594 409 46495034 SGTC_300 r073-0011 5.04 µM 0.231320930054809 0.46047970870897 no 1534 0.408532743875367 433 2735780 SGTC_1169 aniline yellow 25.8 µM 0.231125471246911 0.460540741393502 no 1535 0.408608663790539 458 6051 A DNA damaging agent. SGTC_1779 st039427 55 µM 0.230871906804379 0.460619919147158 no 1536 0.408707158148701 444 1124498 SGTC_374 0880-0231 82.3 µM 0.229661061715547 0.460998037777439 no 1537 0.409177577200665 450 6833587 SGTC_1457 k015-0032 57.3 µM 0.227983578623724 0.461521934749925 no 1538 0.409829503369797 417 4302660 SGTC_1301 naphtanilide LB 4.81 µM 0.225791812176972 0.462206548728334 no 1539 0.410681672790928 450 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_788 1182-0090 188 µM 0.225245067186829 0.462377345980254 no 1540 0.410894315783481 403 5715185 SGTC_448 monastrol 171 µM 0.224090203342768 0.462738135783068 no 1541 0.411343557628443 454 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2723 salbutamol 83.58 µM 0.222899530597313 0.463110144701129 no 1542 0.41180685086392 457 9884233 β2-adrenoceptor agonist SGTC_1167 k781-0610 148 µM 0.222785133844462 0.463145888058205 no 1543 0.411851369362808 429 4525169 SGTC_2788 5282734 71.43 µM 0.221897500612983 0.463423239861541 no 1544 0.412196838128175 441 743706 SGTC_1922 5578187 25 µM 0.221490114479739 0.463550538576301 no 1545 0.412355416487869 458 1350412 SGTC_2452 5863136 48.41 µM 0.221187389035587 0.463645135671765 no 1546 0.412473264093427 447 2184096 SGTC_1210 3013-0140 750 nM 0.219771595358378 0.464087576854974 no 1547 0.413024521211647 447 905973 SGTC_1359 1582-0056 520 nM 0.219619137057026 0.464135223342112 no 1548 0.413083893023381 449 3661189 SGTC_1390 3413-2614 145 µM 0.218849320496289 0.464375815359995 no 1549 0.413383712897106 465 3421432 SGTC_2185 6113692 200 µM 0.21806847606056 0.464619867244777 no 1550 0.413687879394865 439 874150 SGTC_155 k072-0202 43.6 µM 0.217221440589642 0.464884622097564 no 1551 0.414017888203339 469 5857737 SGTC_1683 st010134 710 nM 0.216744839213646 0.465033598530286 no 1552 0.414203600942737 435 3818134 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.216639223670036 0.465066612584063 no 1553 0.414244757748469 440 6708784 An antioxidant flavonoid SGTC_1193 1488-0126 41.5 µM 0.216487781548878 0.465113951853185 no 1554 0.414303774132686 428 1384710 SGTC_2954 9074818 52.69 µM 0.215775564762466 0.465336590197848 no 1555 0.414581348069576 457 16648742 SGTC_2653 dihydrofissinolide 100 µM 0.213061446697795 0.46618512000034 no 1556 0.415639517633262 442 6857746 SGTC_1696 st025591 34.7925 µM 0.212893670989316 0.466237577736686 no 1557 0.415704949523911 423 2787147 SGTC_1305 1181-0477 144 µM 0.210516229369182 0.46698098518649 no 1558 0.41663239312747 431 6252086 SGTC_1136 pergolide 1.05886 µM 0.209306143764805 0.467359413918152 no 1559 0.417104627983824 483 47811 A dopamine receptor agonist. SGTC_445 e6 berbamine 66 µM 0.208337438123711 0.467662377440532 no 1560 0.417482750760535 451 6610268 A calcium/calmodulin antagonist. SGTC_2137 5261020 140 µM 0.208250481809545 0.467689574021417 no 1561 0.417516696866087 445 763655 SGTC_382 3229-0966 23.2 µM 0.205502935610347 0.46854897749561 no 1562 0.418589602379627 461 5722370 SGTC_1666 st014829 29 µM 0.204812907729872 0.468764834125225 no 1563 0.418859150940973 446 3858230 SGTC_2094 5332512 191.667 µM 0.204242877634047 0.468943159609915 no 1564 0.419081852991881 467 755774 SGTC_205 1486-1330 71.903 µM 0.203761157393642 0.469093863521452 no 1565 0.419270073949165 451 4118834 SGTC_2572 astragaloside iv 100 µM 0.201095566142543 0.469927860665969 no 1566 0.420311924442841 422 45006101 An anti-inflammatory agent. SGTC_2808 7946468 45.46 µM 0.200863301115198 0.470000536912834 no 1567 0.420402732151323 459 2970879 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.200377476541032 0.470152555737884 no 1568 0.420592686692655 463 65057 A dermal irritant. YDR527W RBA50 SGTC_123 0083-0120 66.675 µM 0.199886716306961 0.470306123391492 no 1569 0.420784589823148 461 16001701 SGTC_1676 st018489 23.4 µM 0.199355861275153 0.47047224239597 no 1570 0.420992192511368 472 3696235 SGTC_1982 st072467 71.9 µM 0.199268012748494 0.470499733090027 no 1571 0.421026549755416 439 3163533 SGTC_904 1141-0088 396 µM 0.196454645574877 0.471380201868226 no 1572 0.422127164239281 458 1378119 SGTC_599 1935-0052 86.5 µM 0.196417911026437 0.47139169921304 no 1573 0.422141539166845 444 9557311 SGTC_3288 9119690 36.221 µM 0.195246722671579 0.471758275478464 no 1574 0.422599901716414 467 17595618 YKL019W RAM2 SGTC_1314 1222-0010 41.1 µM 0.195066315491553 0.471814744183813 no 1575 0.422670516169357 441 3526027 SGTC_1287 0971-0001 34.6 µM 0.194229194474839 0.472076776295658 no 1576 0.42299821212316 438 4665869 SGTC_3106 9121286 49.47 µM 0.194078909226187 0.47212381923722 no 1577 0.423057047817297 415 15943471 SGTC_178 4092-0806 87.505 µM 0.193882165356052 0.472185405446046 no 1578 0.423134074352231 455 2169044 SGTC_1505 k297-0037 20.6 µM 0.193341554626037 0.472354634800531 no 1579 0.423345742172627 425 4089396 SGTC_1984 st072354 53.1 µM 0.191944356218926 0.472792027971501 no 1580 0.423892896067992 463 5762938 SGTC_1965 Pectolinarigenin 58.4 µM 0.190871730976349 0.473127835754499 no 1581 0.424313044190321 432 5320438 An anti-inflammatory. SGTC_1072 oxiconazole 14.9 nM 0.190446694821365 0.473260907515826 no 1582 0.42447955499956 460 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1753 st043925 64 µM 0.190314733168698 0.47330222312547 no 1583 0.424531254619397 463 670181 SGTC_3052 9092717 49.47 µM 0.189313173570153 0.473615808745245 no 1584 0.424923685499739 451 25237534 SGTC_708 3448-5400 146 µM 0.18594364445903 0.474670918170385 no 1585 0.426244477828269 479 3462195 SGTC_1868 st057644 42.7 µM 0.184368841090431 0.47516410182547 no 1586 0.426862055996066 426 688665 SGTC_114 0364-0001 490.298 µM 0.184012241412222 0.475275784020713 no 1587 0.427001925823632 419 4003655 SGTC_3022 9087993 49.47 µM 0.183271042976708 0.475507923549158 no 1588 0.427292676960632 476 17173644 SGTC_1091 telmisartan 47.6 µM 0.17982126852093 0.476588483262151 no 1589 0.428646442959843 462 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2337 9009472 200 µM 0.179508434555 0.476686479687244 no 1590 0.428769247541254 484 5742383 SGTC_2544 sphondin 68.51 µM 0.178483644467995 0.477007508907811 no 1591 0.429171582394751 481 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3352 9151559 45.5865 µM 0.17742259000323 0.477339914151654 no 1592 0.429588232267797 443 17159339 SGTC_651 3253-0966 34.4 µM 0.176029696555479 0.477776301215446 no 1593 0.430135306118246 449 781462 SGTC_1229 0139-0193 12.2 µM 0.175752815742477 0.477863049883017 no 1594 0.430244070045919 452 3090752 SGTC_2897 9048598 12.99 µM 0.175151056942853 0.478051588674936 no 1595 0.430480470323831 443 6467404 SGTC_290 2043-6722 48.1 µM 0.174775340895135 0.478169307851356 no 1596 0.430628082597914 466 773758 YLR208W SEC13 SGTC_3047 9092122 49.47 µM 0.174713582757107 0.478188658064834 no 1597 0.43065234722004 457 17173831 SGTC_1768 st044301 37.178 µM 0.174304246142796 0.478316913728991 no 1598 0.43081318119393 494 3931349 SGTC_763 3453-1109 128 µM 0.173172157153397 0.478671637909356 no 1599 0.431258054173329 479 1560353 SGTC_138 0850-0259 40.9225 µM 0.173085707547912 0.478698726376623 no 1600 0.431292029558657 470 6813004 SGTC_332 4112-0506 40.9 µM 0.172045048058998 0.479024818494055 no 1601 0.431701056871478 487 2790355 SGTC_3109 9122853 49.47 µM 0.171473586050177 0.479203892905853 no 1602 0.43192569905185 485 1234709 SGTC_758 0868-0029 16 µM 0.171416307522469 0.479221842045278 no 1603 0.431948216502672 447 762687 SGTC_277 nystatin 15.5 µM 0.171139999171407 0.479308428261474 no 1604 0.432056842505645 476 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_921 1561-0023 372 µM 0.169994174830238 0.479667503405046 no 1605 0.43250735889361 476 24050882 SGTC_1740 st038286 13.222 µM 0.169448007488999 0.479838665584096 no 1606 0.432722132449549 446 716786 SGTC_792 4534-1957 155 µM 0.168780505831139 0.48004785750217 no 1607 0.432984646211416 444 1717904 SGTC_948 3448-0295 75.3 µM 0.168767267210275 0.480052006480202 no 1608 0.432989852970134 439 678569 SGTC_2621 lithochol-11-enic acid 100 µM 0.168519011224254 0.480129810198218 no 1609 0.433087494374215 471 6708711 SGTC_3284 9108171 64.8615 µM 0.166680035253137 0.480706170807169 no 1610 0.433810907662091 480 8687505 SGTC_2975 9084847 53.72 µM 0.166150135542266 0.480872256274742 no 1611 0.434019399986873 434 27211724 SGTC_1479 0549-0158 134 µM 0.164934707101728 0.481253218215128 no 1612 0.434497687086908 448 5440202 SGTC_3161 9100388 49.47 µM 0.16476370958673 0.481306816783678 no 1613 0.434564984571445 472 25236368 SGTC_201 4262-0159 12.803 µM 0.160381003485984 0.482680673177356 no 1614 0.436290476467358 477 1341029 SGTC_2693 st077581 40.7 µM 0.160143368814822 0.482755171058933 no 1615 0.436384069316227 484 25238761 SGTC_1158 4092-0494 91.8 µM 0.160024572302055 0.482792413697719 no 1616 0.436430858875243 477 1148199 SGTC_2638 epoxomicin 18 µM 0.157024018753875 0.483733134438882 no 1617 0.437612959342032 475 9915668 A protesome inhibitor. SGTC_265 mycophenolic acid 32.932 µM 0.156952410583527 0.483755585853977 no 1618 0.437641177001247 475 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3124 9127567 49.47 µM 0.156424704013493 0.483921040055636 no 1619 0.437849132933719 468 17592030 SGTC_200 k038-0079 37.545 µM 0.154100254937278 0.484649867545828 no 1620 0.43876534363532 469 3436683 SGTC_3076 9116187 49.47 µM 0.154072347172226 0.484658618299767 no 1621 0.438776345834079 479 27241210 SGTC_285 1486-1325 46 µM 0.152982099731252 0.485000481837682 no 1622 0.43920619573228 465 22310230 SGTC_2289 7946404 165.07 µM 0.152598856220204 0.485120656255902 no 1623 0.439357313519713 454 1246120 YPR165W RHO1 SGTC_482 fipronil 114 µM 0.152233446279062 0.485235239825412 no 1624 0.439501407534866 462 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1266 0828-0227 32.9 µM 0.14750051223417 0.486719478281357 no 1625 0.441368487723809 461 3913820 SGTC_3191 9110352 49.47 µM 0.147330234228908 0.486772880667972 no 1626 0.441435684699769 480 17122424 SGTC_1714 st033236 13.627 µM 0.146950528018362 0.486891964533373 no 1627 0.441585534601593 473 2916566 SGTC_581 0958-0271 211 µM 0.145679496822964 0.487290595132144 no 1628 0.442087203919999 461 4591145 SGTC_3226 9131256 49.47 µM 0.145145697350159 0.487458013245905 no 1629 0.442297919506479 461 17178073 SGTC_504 lovastatin 124 µM 0.144734997012549 0.487586824687759 no 1630 0.442460053230361 482 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_96 0929-0093 37.281 µM 0.143191927198135 0.488070802267252 no 1631 0.443069302642531 465 6991579 SGTC_2222 6885208 172.143 µM 0.142122260998294 0.488406309078714 no 1632 0.443491717460782 465 609514 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.142069053904737 0.48842299799862 no 1633 0.443512730803505 466 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_716 1683-5115 658 µM 0.141729281200923 0.488529571472768 no 1634 0.443646922674791 498 723597 SGTC_133 0724-0033 378.92 µM 0.139590758383232 0.489200361347161 no 1635 0.444491671434188 512 280309 SGTC_1835 st008666 49.2 µM 0.13950325485295 0.489227809219341 no 1636 0.444526242044964 464 690455 SGTC_440 fluspirilene 35.1 µM 0.137331003368807 0.489909211248594 no 1637 0.445384582723647 483 3396 An atypical antipsychotic. SGTC_2069 5228469 200 µM 0.137130629559136 0.489972066958551 no 1638 0.445463771136604 489 2835210 SGTC_1192 1488-0095 21.4 µM 0.136865261924105 0.490055311110465 no 1639 0.445568648679553 477 915875 SGTC_383 2324-0395 7.37 µM 0.136235753535419 0.490252785644049 no 1640 0.445817455707878 491 3146421 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.13538158217293 0.490520739961486 no 1641 0.44615509268028 484 6708760 SGTC_1915 st067105 30.6 µM 0.135218309682162 0.490571959178041 no 1642 0.446219635505189 498 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_36 0335-0881 14.2 µM 0.135144755043526 0.490595033605636 no 1643 0.446248712664311 479 23828853 SGTC_2859 9028643 45.46 µM 0.133981760337036 0.490959874513128 no 1644 0.446708498762412 471 17151580 SGTC_1121 fusaric acid 630.51 nM 0.13382349169008 0.491009525267632 no 1645 0.446771075299159 458 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1238 0333-0287 48.8 µM 0.132942578898536 0.491285880598119 no 1646 0.447119396327925 468 7226 SGTC_40 0327-0103 19.753 µM 0.132114404709585 0.491545694868649 no 1647 0.447446901236683 468 409036 SGTC_2358 9037157 4 µM 0.131991306259128 0.491584313543721 no 1648 0.447495584092587 495 2388925 SGTC_2985 9022375 71.43 µM 0.129439065073928 0.492385024636925 no 1649 0.448505119103351 463 4939335 SGTC_362 0310-0100 9.03 µM 0.128785953800334 0.4925899293918 no 1650 0.448763510104932 472 790235 SGTC_926 2268-1401 59.4 µM 0.127776394246883 0.492906668761039 no 1651 0.44916296578648 506 2931578 SGTC_325 2810-4341 181 µM 0.126585015887264 0.493280457728025 no 1652 0.449634428559192 470 774970 SGTC_2480 5767542 37.17 µM 0.126183357019854 0.493406477523323 no 1653 0.449793392615978 484 2867358 SGTC_2776 terbinafine 19.92 µM 0.124519696837701 0.493928454979582 no 1654 0.450451902962753 489 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2285 7945142 200 µM 0.122360415967874 0.494605950010629 no 1655 0.451306793185573 490 2970608 SGTC_2036 5160441 105 µM 0.122190581660433 0.494659237834864 no 1656 0.451374042654164 476 134534 YIL048W NEO1 SGTC_3023 9089636 49.47 µM 0.121158629810817 0.494983028779644 no 1657 0.451782695642175 497 17249241 SGTC_130 0136-0219 337.655 µM 0.12074639290992 0.495112375455457 no 1658 0.45194595578406 506 234244 SGTC_851 0394-0702 453 µM 0.119169494665353 0.49560716001203 no 1659 0.452570537062507 482 762646 SGTC_3178 9107506 49.47 µM 0.118133110042065 0.495932350927793 no 1660 0.452981094552921 489 8897194 SGTC_625 k213-0058 121 µM 0.117861660767851 0.49601752520395 no 1661 0.453088635863575 499 3655420 SGTC_2269 7935389 174.42 µM 0.11726173294186 0.49620576881512 no 1662 0.45332632423066 477 97605 SGTC_1472 k841-0093 193 µM 0.116606168028071 0.496411471034651 no 1663 0.453586074846916 488 X1472 SGTC_2399 5884133 200 µM 0.115955274223457 0.496615708504306 no 1664 0.45384399430254 465 722445 SGTC_2999 9069765 71.4286 µM 0.115299648764076 0.496821431569278 no 1665 0.454103808376232 502 2097066 SGTC_994 3910-0338 138 µM 0.1152831015362 0.496826623792532 no 1666 0.45411036603736 496 3479481 SGTC_2839 9003951 25.97 µM 0.115010789752794 0.49691207042152 no 1667 0.454218284905789 502 2990634 SGTC_317 4495-0002 170 µM 0.114844475934015 0.496964256830914 no 1668 0.454284197778765 481 15991618 SGTC_1884 5633444 25 µM 0.113919048681152 0.49725464087417 no 1669 0.454650982602098 490 5724239 SGTC_3279 9140807 49.47 µM 0.11214911175066 0.497810022260666 no 1670 0.455352588732477 498 45595718 SGTC_1360 1598-0022 39.8 µM 0.111401854761617 0.498044502360493 no 1671 0.455648844665292 497 761525 SGTC_713 1488-1073 324 µM 0.111220531353253 0.498101399532322 no 1672 0.45572073548664 507 3312542 SGTC_231 b-estradiol 524 µM 0.110334044123522 0.498379569425437 no 1673 0.456072229384515 503 450 A steroid. SGTC_2614 arthonioic acid 13.39 µM 0.110095527338755 0.498454413495969 no 1674 0.456166807631205 485 6710684 SGTC_3154 9100113 49.47 µM 0.109796993361052 0.498548090409793 no 1675 0.456285187789632 471 25237525 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.107293358322709 0.499333708170175 no 1676 0.45727812670929 495 165506 SGTC_2926 9010726 65.15 µM 0.107287006219161 0.499335701406705 no 1677 0.457280646288483 474 2994293 SGTC_371 0195-0006 7.36 µM 0.106746841225682 0.499505200682331 no 1678 0.457494910477164 489 3928593 SGTC_2658 polymyxin b sulfate 77.05 µM 0.103593163385992 0.499505200682331 no 1679 0.458746106650236 491 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3330 9141424 71.43 µM 0.103196664088796 0.499380782495084 no 1680 0.458903443724663 475 27261020 SGTC_442 cape 100 µM 0.102628922813058 0.499202630104721 no 1681 0.459128743476615 505 5281787 SGTC_1954 st077032 68.9 µM 0.10248663214165 0.499157980524071 no 1682 0.459185211491196 506 698907 SGTC_3332 9141069 11.198 µM 0.101518815358313 0.498854288305938 no 1683 0.4595693111113 506 17332883 SGTC_3338 9144300 39.5675 µM 0.100978977528143 0.498684892318352 no 1684 0.459783574182607 488 4901274 SGTC_1947 st076332 61.6 µM 0.0999774821138436 0.498370633213418 no 1685 0.460181101265308 513 24208416 SGTC_2107 5363541 170.161 µM 0.0999056328219254 0.498348087670782 no 1686 0.460209622191397 516 244052 SGTC_1030 k029-0042 36.7 µM 0.0978420070374805 0.497700546412303 no 1687 0.461028875297635 461 6080581 SGTC_2586 curcumin 80 µM 0.0976787947890156 0.497649332583617 no 1688 0.461093677164286 484 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_413 propylparaben 100 µM 0.0974631284284379 0.497581659413081 no 1689 0.461179307020096 486 7175 A pharmaceutical preservative. SGTC_405 ebelactone b 50 µM 0.0970814365023402 0.497461889850093 no 1690 0.461330861372046 500 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_518 1021-0119 62.6 µM 0.0967869282586974 0.497369477457373 no 1691 0.461447802466295 484 1097762 SGTC_1581 himbacine 57.9 µM 0.0965736116218927 0.497302541894911 no 1692 0.461532506696793 487 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2263 7948595 193.29 µM 0.0961654878336646 0.497174478982222 no 1693 0.461694570231156 492 2971371 SGTC_463 ikarugamyin 104 µM 0.0958434230897958 0.497073420267332 no 1694 0.461822464721271 520 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1153 4055-0057 267 µM 0.0951887784844481 0.496868003949195 no 1695 0.462082441492988 503 882706 SGTC_208 k072-0098 12.366 µM 0.0949676010435127 0.49679860242336 no 1696 0.462170280600139 508 5948901 SGTC_2790 5423970 71.43 µM 0.094170450583952 0.49654847168293 no 1697 0.462486878727817 483 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1302 1159-0335 255 µM 0.0926110876624449 0.496059177098969 no 1698 0.46310626746359 502 649284 SGTC_3324 9138759 60.749 µM 0.0924261444638797 0.496001146275419 no 1699 0.463179734025403 495 45595710 SGTC_1837 st055472 66.5 µM 0.0899495957540852 0.495224072211271 no 1700 0.464163634570785 482 676091 SGTC_3312 9133330 71.43 µM 0.0891416273328984 0.494970557330733 no 1701 0.464484677614467 507 17617324 SGTC_1788 fluconazole 20 µM 0.0890232437890464 0.494933412495215 no 1702 0.464531718792717 507 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2675 theaflavin digallate 100 µM 0.08832745780002 0.494715098792794 no 1703 0.464808208035119 509 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_77 0828-0286 12.516 µM 0.0873600161289167 0.494411551529132 no 1704 0.465192675166738 458 745345 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0870953371137915 0.494328505641211 no 1705 0.465297865873565 491 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2129 girgensonine 121.053 µM 0.0865496020076612 0.494157276161552 no 1706 0.465514763633096 518 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_326 k292-0812 17.5 µM 0.0857529454171428 0.493907319667199 no 1707 0.465831406370779 512 3579357 SGTC_162 k030-0015 37.8 µM 0.0847035481913967 0.493578067723799 no 1708 0.466248537529566 500 1809920 YMR134W ERG29 SGTC_2967 9089538 49.85 µM 0.0833989005359323 0.493168736217143 no 1709 0.466767181356541 520 728216 SGTC_1367 1812-0510 76.9 µM 0.0818595718626155 0.492685783129468 no 1710 0.467379191739108 504 1142582 YDR527W RBA50 SGTC_2426 5582046 32.21 µM 0.0799899987225905 0.492099232747335 no 1711 0.468122605172643 493 2251934 SGTC_2315 7733312 200 µM 0.0794106509117616 0.491917474515298 no 1712 0.468352998597111 484 726316 SGTC_2863 9028737 58.44 µM 0.0793591609274936 0.491901320692654 no 1713 0.46837347550473 514 6460917 SGTC_19 0279-0214 38.434 µM 0.0781737146081631 0.491529417341354 no 1714 0.468844935360154 519 3566274 YBR002C RER2 SGTC_1825 st052143 62.6 µM 0.0772645886212551 0.491244207372822 no 1715 0.469206530426089 508 674173 SGTC_3225 9130819 49.47 µM 0.076532412720897 0.491014513231249 no 1716 0.469497763981453 510 4547121 SGTC_661 1304-0007 33.6 µM 0.0764534883309327 0.490989753688186 no 1717 0.469529158276372 503 3117130 SGTC_1264 0783-0040 158 µM 0.075415350638309 0.490664080508828 no 1718 0.469942122973789 505 2855798 SGTC_3206 9114350 49.47 µM 0.0750935234384146 0.49056312166039 no 1719 0.470070150412076 512 17087243 SGTC_402 epigallocatechin gallate 10 µM 0.0739828060806291 0.490214688595093 no 1720 0.470512033261553 507 65064 An antioxidant. SGTC_2372 9071633 200 µM 0.0737855247507475 0.490152802032251 no 1721 0.470590522600872 520 21321366 SGTC_1841 st054148 70 µM 0.0726803404194594 0.489806113440792 no 1722 0.471030246619906 506 675442 SGTC_2114 5491910 81.25 µM 0.0724366312854085 0.489729664617985 no 1723 0.471127216899735 529 2849228 SGTC_1553 gossypol 38.6 µM 0.0723016703821762 0.489687329058013 no 1724 0.471180917702467 514 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1105 epirubicin 18.1 µM 0.0720675263009126 0.489613881242246 no 1725 0.471274084630955 520 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_693 4161-2696 114 µM 0.071797628035387 0.489529218261984 no 1726 0.47138148025208 522 805759 SGTC_2434 5670830 169.91 µM 0.0702176030446089 0.489033598046363 no 1727 0.47201023185162 506 1549830 SGTC_237 nikkomycin 200 µM 0.0690093882773747 0.488654618170181 no 1728 0.472491073276149 512 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1008 4106-0037 6 µM 0.0684708881010745 0.488485710478527 no 1729 0.472705396801789 530 2905394 SGTC_1506 4226-2149 212 µM 0.0681311753213426 0.488379156139385 no 1730 0.472840606844552 511 991114 SGTC_3157 9099274 49.47 µM 0.0673871598831443 0.488145791102506 no 1731 0.473136745441102 518 17217662 SGTC_16 erodoxin 22.806 µM 0.0672031168279847 0.488088065484744 no 1732 0.473210001933195 508 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_626 0214-0009 33 µM 0.0670999060490641 0.488055693245096 no 1733 0.473251084345198 504 3437874 SGTC_3050 9093513 49.47 µM 0.0654282596490141 0.487531389564565 no 1734 0.473916512166823 518 25236664 SGTC_2235 salicylic acid 500 µM 0.0630407638706003 0.486782600834512 no 1735 0.474867021991471 521 338 A COX inhibitor and kinase inhibitor. SGTC_2460 5552655 174.22 µM 0.0628102211478983 0.486710298296909 no 1736 0.474958813321496 476 5401989 SGTC_394 menadione 8.33 µM 0.0620783737750738 0.486480780090221 no 1737 0.475250209501503 527 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_880 0833-0487 87.2 µM 0.0615151112342903 0.486304135636536 no 1738 0.475474490086378 511 76075 SGTC_3038 9091290 49.47 µM 0.0612102998746676 0.486208545033103 no 1739 0.475595863500955 529 25236843 SGTC_2714 st079313 56.9 µM 0.0606705592308524 0.486039281196232 no 1740 0.47581078940184 520 2939799 SGTC_1039 k821-0043 94 µM 0.05998737358045 0.485825036304604 no 1741 0.476082845501579 511 15992768 SGTC_314 1671-0008 2.74 µM 0.0576268796799619 0.48508482465038 no 1742 0.477022919178931 516 3913060 SGTC_507 nimesulide 162 µM 0.0574719947845606 0.48503625709041 no 1743 0.477084607074379 527 4495 A COX2 inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 0.0557184485539099 0.48448640982085 no 1744 0.477783051255875 523 16667744 Haematoxylin. SGTC_1705 st027868 56.3335 µM 0.0556913440455331 0.484477911077881 no 1745 0.477793847626494 528 292948 SGTC_689 0833-0039 98 µM 0.0541203029815766 0.483985316118269 no 1746 0.478419658255768 524 5374726 SGTC_353 1988-1175 58.3 µM 0.0539388235234285 0.48392841536829 no 1747 0.47849195248707 512 2788357 SGTC_236 1509-0011 5.31 µM 0.0537424622407205 0.483866848965918 no 1748 0.478570175845131 530 3107280 SGTC_1128 3448-9350 235 µM 0.0514477613827182 0.483147405704263 no 1749 0.479484363529213 515 619386 SGTC_526 4469-0568 170 µM 0.0503349248449599 0.482798524610745 no 1750 0.479927746515345 497 2901964 SGTC_2939 9044578 71.43 µM 0.050324376463138 0.482795217690812 no 1751 0.479931949384383 517 2653634 SGTC_924 2046-0044 21.3 µM 0.0494849504109998 0.482532061259886 no 1752 0.480266415169212 528 3623589 SGTC_495 decylubiquinone 155 µM 0.0491860364621796 0.482438354863352 no 1753 0.480385519543436 527 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2497 7-hydroxyflavone 100 µM 0.0490565654544686 0.482397767357413 no 1754 0.480437108725077 515 5281894 SGTC_2466 5983409 37.09 µM 0.0486939602467681 0.482284096232111 no 1755 0.480581594596333 510 2879657 SGTC_1679 SEC14.276 6.7 µM 0.0479586005128699 0.482053576758619 no 1756 0.480874618310945 526 1005053 YMR079W SEC14 SGTC_2081 5214970 32.255 µM 0.0461692520408876 0.481492679682339 no 1757 0.481587674823522 517 2063512 SGTC_2253 7938677 135.83 µM 0.0457746050549014 0.481368976786926 no 1758 0.481744949909189 511 2301972 SGTC_1821 st053465 65.6 µM 0.04509505196346 0.481155973707619 no 1759 0.482015772686695 512 675086 SGTC_1562 morin hydrate 59.1 µM 0.0446203577835642 0.481007185986723 no 1760 0.482204957827293 517 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1750 st081859 2.357 µM 0.0445003040779804 0.480969556878553 no 1761 0.482252804799725 531 5291695 SGTC_2581 avocatin a 64 µM 0.0443186707857514 0.480912626856635 no 1762 0.482325194580561 523 6710728 A skin care supplement. SGTC_1527 coumarin 137 µM 0.0428276569980114 0.480445307485403 no 1763 0.482919458557383 532 323 A hepatotoxic, DNA x-linker. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0428187877693299 0.48044252773684 no 1764 0.482922993624859 519 15053 SGTC_2053 5265679 138 µM 0.0412604089972264 0.479954123470837 no 1765 0.483544147609181 524 764595 SGTC_2628 lathosterol 100 µM 0.0406326229571785 0.479757380420697 no 1766 0.483794388132762 514 6710616 SGTC_811 0416-0114 265 µM 0.0394592180295249 0.47938965809948 no 1767 0.484262133737074 534 6612453 SGTC_1764 st044502 93.5 µM 0.0391177967754646 0.479282666588175 no 1768 0.484398236026689 518 8407 SGTC_177 1327-0068 8.361 µM 0.0379857820857319 0.478927936763242 no 1769 0.484849509049634 519 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_949 1165-0505 146 µM 0.0374455082087292 0.478758641595573 no 1770 0.48506489389583 530 6244267 SGTC_623 k072-0108 16.9 µM 0.0361756418393902 0.478360743293614 no 1771 0.485571154134831 528 5382803 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0355749291068023 0.478172524225412 no 1772 0.485810649669337 529 616764 SGTC_2280 7785178 200 µM 0.0351001642438689 0.47802377137307 no 1773 0.4859999352233 525 2954328 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0323628659824742 0.477166184169166 no 1774 0.487091337809467 541 5282309 SGTC_3291 9121177 71.43 µM 0.0310611619971613 0.476758401129918 no 1775 0.487610381474915 525 17015612 SGTC_733 4069-0007 56.1 µM 0.0302634224885434 0.476508506357961 no 1776 0.4879284839139 536 5717425 YNL287W SEC21 SGTC_58 0957-0393 9 µM 0.0301813809429374 0.47648280707079 no 1777 0.487961198810982 532 6997992 SGTC_1907 st060210 83.7 µM 0.0297013548727036 0.476332442196378 no 1778 0.488152615683797 534 688793 SGTC_1710 st031758 61.5 µM 0.0290921960744013 0.476141632235135 no 1779 0.488395529897847 539 5394341 SGTC_389 tpck 16.7 µM 0.0274312361520312 0.475621389089828 no 1780 0.489057892385392 517 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_934 2950-0684 338 µM 0.0267623141024054 0.47541188211021 no 1781 0.489324655716814 535 1121253 SGTC_315 k915-0449 187 µM 0.0264766623664236 0.475322417800975 no 1782 0.489438573903177 528 20970215 YNL149C PGA2 SGTC_2346 9031566 143.75 µM 0.0259215072466728 0.475148550306595 no 1783 0.48965997275354 535 4771086 SGTC_456 gingerol 170 µM 0.0254706413439712 0.475007348344127 no 1784 0.489839782850351 538 442793 A herb. SGTC_1388 3346-4487 254 µM 0.0238680145603851 0.474505464005174 no 1785 0.490478943847115 536 3345614 SGTC_312 4092-0653 6.84 µM 0.0202624613804487 0.473376485169877 no 1786 0.491917000556721 535 1148278 SGTC_1371 2421-0008 32.7 µM 0.0197264973118907 0.4732086809426 no 1787 0.492130776546018 536 2827552 SGTC_1411 3909-8223 150 µM 0.0192856114083277 0.47307064816526 no 1788 0.492306631114061 535 X1411 SGTC_3072 9116419 49.47 µM 0.0191169733607286 0.473017851735743 no 1789 0.492373895560258 537 17170162 SGTC_1816 st051957 91.6 µM 0.0187362910658643 0.472898671206194 no 1790 0.492525738623313 537 674121 SGTC_1935 st074532 41.6 µM 0.0183550801738886 0.472779327619468 no 1791 0.492677793613619 535 2829742 SGTC_3021 9087658 49.47 µM 0.0183398659856444 0.47277456464829 no 1792 0.492683862175057 542 25237042 SGTC_801 0866-0028 10.1 µM 0.0183002411643761 0.472762159674684 no 1793 0.492699667539058 541 6849771 SGTC_2851 9015922 71.43 µM 0.0168777200783445 0.472316841842106 no 1794 0.493267083519039 539 2996893 SGTC_3019 9081971 49.47 µM 0.0164625319364593 0.472186874391536 no 1795 0.493432696609003 535 16451803 SGTC_2097 5376186 200 µM 0.0162883004006251 0.47213233511086 no 1796 0.493502195616286 535 742755 SGTC_3281 9140613 49.47 µM 0.0159688436969518 0.472032337701545 no 1797 0.493629623826516 538 16013766 SGTC_2564 betulinic acid 100 µM 0.0145669699298675 0.471593539397415 no 1798 0.494188825316964 531 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_6 0844-0013 19.835 µM 0.0135530007366389 0.471276179952293 no 1799 0.494593300500894 546 1584900 SGTC_3155 9099265 49.47 µM 0.0123045238707565 0.470885447667543 no 1800 0.495091329051259 540 25236499 SGTC_3217 9129673 49.47 µM 0.0110168746229216 0.470482485075846 no 1801 0.495604991820023 539 17248312 SGTC_1690 st023502 41.2 µM 0.0108447569472905 0.470428624098037 no 1802 0.495673652735933 544 24207482 SGTC_557 1315-0110 16.2 µM 0.00998476878980839 0.470159515160789 no 1803 0.496016719755747 542 6833801 SGTC_3017 9080681 49.47 µM 0.00897081590317737 0.469842244838126 no 1804 0.496421210247428 543 16451914 SGTC_3049 9092223 49.47 µM 0.00755471527496814 0.469399172802406 no 1805 0.496986133329213 540 8623917 SGTC_1124 fisetin 1.16336 µM 0.00737363496408628 0.469342518799651 no 1806 0.497058371908899 542 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1203 3992-3522 103 µM 0.00665988362820646 0.469119215816942 no 1807 0.497343110478805 543 5322312 SGTC_2479 5617353 43.85 µM 0.00588287153611423 0.468876132231142 no 1808 0.497653087351143 541 2731746 SGTC_2008 4012253 172 µM 0.00561871892310922 0.468793496304025 no 1809 0.497758467254085 543 603940 SGTC_1412 3909-8563 178 µM 0.00539761079129022 0.468724327189029 no 1810 0.497846675298108 545 23767530 SGTC_3233 9132340 49.47 µM 0.00373907753378321 0.468205519536677 no 1811 0.498508327357847 546 17682950 SGTC_1042 0350-0096 82 µM 0.00349797610597276 0.468130104802297 no 1812 0.498604512281321 546 3122515 SGTC_1277 0873-0036 22 µM 0.00327424232136064 0.468060123560649 no 1813 0.498693768635674 542 5965735 SGTC_491 tetrandrine 80.3 µM 0.00304981485313002 0.467989926334721 no 1814 0.498783301793851 544 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2583 asiatic acid 100 µM 0.00298479402088743 0.467969589072197 no 1815 0.498809241234856 548 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1421 4029-0249 71.4 µM 0.00297633305681606 0.467966942651934 no 1816 0.498812616656164 544 2894095 SGTC_164 4100-3994 89.624 µM 0.00191496904488955 0.467634980491874 no 1817 0.499236038349255 548 4615967 SGTC_1824 st053723 68.6 µM 0.00111841665844099 0.467385858070301 no 1818 0.499553816400861 545 675225 SGTC_1183 1254-0324 198 µM 0.00103634270666219 0.467360190097852 no 1819 0.499586559151333 545 5799357 SGTC_1693 xanthone 101.9 µM -0.000924489759254067 0.466746996012125 no 1820 0.499631181999772 548 7020 An insecticide. SGTC_1741 st038134 10.228 µM -0.00132224837780075 0.466622617999117 no 1821 0.499472499370612 549 1272587 SGTC_63 0099-0242 26.702 µM -0.00282795871838339 0.466151816190626 no 1822 0.498871809203763 550 3898502 YLR359W ADE13 SGTC_2713 st079149 53.4 µM -0.00295202867411571 0.466113024404996 no 1823 0.498822312659426 550 3103253 SGTC_3144 9087057 49.47 µM -0.00403498892382739 0.465774439123291 no 1824 0.498390276685356 552 17249618 SGTC_1870 st057514 26.5 µM -0.00435030059963878 0.465675862225688 no 1825 0.498264486632482 551 5393161 SGTC_682 0kpi-0099 17 µM -0.00489924518257696 0.465504248953624 no 1826 0.498045491773501 553 1714895 YML126C ERG13 SGTC_825 1988-2224 89.6 µM -0.0055388449574799 0.465304302783261 no 1827 0.497790331860208 550 1180859 SGTC_255 tunicamycin 200.472 nM -0.00593988790311429 0.465178936658 no 1828 0.497630341509099 553 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2730 imipramine 71.33 µM -0.00779152601742572 0.464600159128389 no 1829 0.49689166229293 554 3696 A tricyclic antidepressant. SGTC_2414 st077232 92.9 µM -0.00920571274356751 0.464158168756214 no 1830 0.496327503836472 551 729801 SGTC_2455 5377712 9.75 µM -0.0092274688458619 0.464151369441085 no 1831 0.496318824776042 553 2243908 SGTC_3198 9112019 49.47 µM -0.00952001979068514 0.464059941119197 no 1832 0.496202118962809 552 45595555 SGTC_2176 5809774 33.9695 µM -0.00954442279002479 0.464052314754459 no 1833 0.496192384016888 552 2870539 SGTC_269 exalamide 29 µM -0.0105754986196856 0.463730097601185 no 1834 0.495781065106197 557 3316 A derivative of salicylamide. SGTC_877 0771-0151 33.1 µM -0.0128824752327383 0.463009240558243 no 1835 0.494860778103138 551 6166523 SGTC_2453 5731132 22.18 µM -0.0144471556504957 0.462520396515793 no 1836 0.494236619269273 558 1362040 SGTC_847 0342-0274 5.54 µM -0.0165455230541954 0.461864904722375 no 1837 0.49339959245206 565 18097 SGTC_2867 9039098 71.43 µM -0.0173486867674616 0.461614038304058 no 1838 0.49307922250649 568 6463460 SGTC_1415 3966-0071 78.1 µM -0.0175373552477217 0.46155511033091 no 1839 0.493003966122433 558 2893185 SGTC_2543 pimpinellin 60.67 µM -0.0188472951120251 0.461145992195187 no 1840 0.49248146223441 563 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_562 3772-2733 112 µM -0.0196938896881853 0.460881607099205 no 1841 0.492143782579163 556 2876874 YIL048W NEO1 SGTC_2155 5570423 76 µM -0.0240487811027247 0.459521883141379 no 1842 0.49040684912492 565 797402 SGTC_899 1083-0020 478 µM -0.0265524285808273 0.458740384724857 no 1843 0.489408358179846 562 767123 SGTC_2273 7815444 169.05 µM -0.0271149011823892 0.458564834130732 no 1844 0.489184044852919 559 2824616 SGTC_804 1595-0054 20.9 µM -0.0286733854975603 0.458078465474104 no 1845 0.48856254146685 575 761523 Stimulates phospholipase C. SGTC_935 2996-0153 430 µM -0.0308462298325789 0.457400473485093 no 1846 0.487696085934722 564 23738523 SGTC_1734 st037168 69.4 µM -0.0311815463443893 0.457295855762363 no 1847 0.487562378321022 580 708907 SGTC_2098 5376439 882.5 nM -0.0315319952234666 0.457186519950151 no 1848 0.487422638163194 572 2844116 SGTC_2476 5806916 10.51 µM -0.0319132069673872 0.457067590176131 no 1849 0.487270633184009 566 2870194 SGTC_446 go6976 132 µM -0.0360882561857129 0.455765319562239 no 1850 0.485605993217828 562 3501 A protein kinase C inhibitor. SGTC_1254 0550-0035 264 µM -0.0368416526350104 0.455530372274932 no 1851 0.485305631288358 565 15121435 SGTC_723 4182-0001 115 µM -0.0416428729249845 0.454033476640117 no 1852 0.483391697607609 575 744821 YLR208W SEC13 SGTC_2429 5902844 64.44 µM -0.0427566576413561 0.453686320018968 no 1853 0.482947757280895 563 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2288 7946289 167.31 µM -0.0442465997064152 0.453221973929337 no 1854 0.482353918604273 578 1246052 SGTC_3102 9121669 49.47 µM -0.0443717164330607 0.453182983729273 no 1855 0.48230405322648 569 41905072 SGTC_1116 jasmonic acid  1.58368 µM -0.0444193835751387 0.453168129308098 no 1856 0.482285055519256 562 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1375 2910-0797 186 µM -0.0446924017334008 0.453083050439853 no 1857 0.482176245093296 562 742508 SGTC_993 3909-8757 62.7 µM -0.0451783782518859 0.45293161407755 no 1858 0.481982564152674 566 4288324 YLR208W SEC13 SGTC_563 tetrahydrosecaminediol 614 µM -0.0482106045347506 0.451986889901397 no 1859 0.480774199409907 572 334274 A psychoactive constituent of the cannabis plant. SGTC_1265 0819-1001 68.8 µM -0.0492626135904144 0.451659187893824 no 1860 0.480355006678538 579 3106768 SGTC_2549 cedrol 20.94 µM -0.0494236289375606 0.451609034332391 no 1861 0.480290849000146 573 6708665 A sedative which affects the nervous system. SGTC_3015 9080845 49.47 µM -0.0503657193374056 0.451315604588231 no 1862 0.479915476852915 569 5296973 SGTC_1419 3993-2473 62.6 µM -0.0527979008547792 0.450558184516231 no 1863 0.478946467022463 573 704026 SGTC_3089 9117425 49.47 µM -0.0531567161132865 0.450446458900533 no 1864 0.478803521182126 563 9401657 SGTC_3205 9113483 49.47 µM -0.0537434331221487 0.450263779149566 no 1865 0.478569789078433 583 17018033 SGTC_350 k064-0020 19.8 µM -0.0543773999769608 0.450066399568919 no 1866 0.478317242207392 583 2790705 SGTC_2121 5257820 149.641 µM -0.0550304840192673 0.449863080948841 no 1867 0.478057088923356 570 791256 SGTC_2282 7944268 200 µM -0.0560241679291424 0.449553751781717 no 1868 0.477661277085348 591 2970414 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0561836723723509 0.449504101642552 no 1869 0.477597744087647 564 641818 SGTC_3179 9107801 49.47 µM -0.0562308702084559 0.449489410171188 no 1870 0.477578944594968 569 4818259 SGTC_2877 9040724 71.43 µM -0.0569466219407936 0.44926662358079 no 1871 0.477293857803118 588 6463895 SGTC_1570 verbenone 133 µM -0.0593631748749007 0.44851456011006 no 1872 0.476331421751078 569 29025 A natural terpanoid with antifungal properties. SGTC_1310 1188-0297 994 nM -0.0598794418545371 0.448353914836723 no 1873 0.47612582676642 576 1588352 SGTC_2141 5621638 7.665 µM -0.0599976208514535 0.448317142617022 no 1874 0.476078764781987 579 2856238 SGTC_2160 5660466 132.927 µM -0.0601222561607465 0.448278361951788 no 1875 0.476029132085723 589 2859134 SGTC_1338 1486-1223 76 µM -0.0609218831978481 0.448029567279011 no 1876 0.475710710770944 594 3444526 SGTC_1539 benzyladenosine 56 µM -0.0638520557466888 0.447118053531138 no 1877 0.474544014149355 582 92208 A nucleotide analog. SGTC_848 0368-0089 85.6 µM -0.0650481231417204 0.446746062641584 no 1878 0.474067842315918 575 762535 SGTC_131 0141-0277 33.849 µM -0.0656535654678632 0.446557780867417 no 1879 0.473826820996077 593 1547771 SGTC_2772 vinpocetine 57.06 µM -0.0662456903531956 0.446373652232145 no 1880 0.473591110499371 570 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1516 st013856 110 µM -0.0682023981496643 0.445765271929108 no 1881 0.472812258985732 608 5281404 A mutagen and neurotoxin. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0688284593117968 0.445570643656105 no 1882 0.472563082272121 588 6728940 SGTC_600 1495-0418 41.6 µM -0.069467014047688 0.445372144925269 no 1883 0.472308944090127 580 5377768 SGTC_1389 3405-0187 19 µM -0.0701723758850479 0.445152894709744 no 1884 0.472028230480471 583 799890 SGTC_417 st075190 100 µM -0.0712698614909435 0.444811792601897 no 1885 0.471591490630844 575 222757 SGTC_649 1123-0311 367 µM -0.0716155662702599 0.444704354879418 no 1886 0.471453925896296 581 693629 YIL048W NEO1 SGTC_609 0986-0026 86.3 µM -0.0717500103279927 0.44466257361081 no 1887 0.471400428101201 593 2848610 SGTC_1330 1469-0054 61.8 µM -0.0719178683685966 0.444610409119772 no 1888 0.471333634984356 577 7102664 SGTC_476 mead acid 10 µM -0.0720903712807539 0.444556802162336 no 1889 0.471264994446756 582 5312531 An omega 9 fatty acid. SGTC_2608 thymoquinone 42.66 µM -0.0723202331626651 0.444485371923424 no 1890 0.471173531560356 576 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3256 9138902 49.47 µM -0.0731101486922345 0.444239917165473 no 1891 0.47085923289211 572 17228773 SGTC_855 0428-0020 25 µM -0.0736543009976029 0.444070842187725 no 1892 0.47064273124402 581 6812414 SGTC_359 0081-0058 15.9 µM -0.0738563601396622 0.444008062456137 no 1893 0.47056234026427 571 3494159 SGTC_2636 apigenin dimethyl ether 100 µM -0.0760519163775555 0.443325994514465 no 1894 0.469688897231364 604 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1699 st031318 29.054 µM -0.0762457174782161 0.443265796612888 no 1895 0.469611805616125 581 5340658 SGTC_2382 9035899 200 µM -0.0783788349072905 0.442603301064127 no 1896 0.468763354513708 587 6462679 SGTC_1529 apigenin 74 µM -0.0787109363306542 0.442500172648384 no 1897 0.46863127326853 598 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_327 1273-0057 3.96 µM -0.079552558012437 0.442238838896832 no 1898 0.468296564393249 590 3108138 SGTC_874 0599-0792 117 µM -0.0806632602873764 0.44189399084551 no 1899 0.467854877806176 578 765305 SGTC_3245 9134821 49.47 µM -0.081252324195249 0.44171111761669 no 1900 0.467620644172804 593 17014901 SGTC_1343 1487-0095 224 µM -0.0814463391781041 0.441650888930429 no 1901 0.467543499078089 592 4560101 YGL055W OLE1 SGTC_62 0180-0423 3.232 µM -0.0825223958307032 0.441316869781018 no 1902 0.467115654886455 583 30102 YGL099W LSG1 SGTC_2846 9008642 19.48 µM -0.0853375442338068 0.440443216517441 no 1903 0.465996522200398 615 2992898 SGTC_1019 4262-0212 3.4 µM -0.0853495107533026 0.440439503442973 no 1904 0.46599176560378 580 4677213 SGTC_3013 9080133 71.4286 µM -0.0861941173704201 0.440177444894963 no 1905 0.465656053481989 586 17050193 SGTC_3290 9121031 71.43 µM -0.0863114696939643 0.440141035719465 no 1906 0.465609410502801 581 17014854 SGTC_283 0987-0079 11.7 µM -0.0863758134560861 0.44012107294373 no 1907 0.465583836563242 581 411556 SGTC_2119 5528445 120.635 µM -0.0884191749262218 0.439487195563388 no 1908 0.464771760797498 597 791935 SGTC_2474 5321570 43.32 µM -0.0890901877405214 0.439279072389605 no 1909 0.464505117717373 567 2841384 SGTC_823 0417-1665 178 µM -0.0891029456485916 0.439275115524273 no 1910 0.464500048209797 608 3429856 SGTC_1810 st050138 53 µM -0.0922911424932898 0.438286487462539 no 1911 0.463233362800981 589 3444541 SGTC_2489 cantharidin 73.42 µM -0.0923202209442713 0.438277472287171 no 1912 0.463221811492937 591 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1005 4092-0690 4.4 µM -0.0961768751652779 0.437082081629082 no 1913 0.461690048302963 614 1529343 SGTC_2541 muurolladie-3-one 83.07 µM -0.0983848920220247 0.436397952729351 no 1914 0.460813335447298 625 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3315 9136395 68.55 µM -0.0990314196553423 0.436197669409784 no 1915 0.460556661718709 590 16876844 SGTC_1939 st074455 53.6 µM -0.0999793111429766 0.435904058255193 no 1916 0.460180375225966 578 1644229 SGTC_1978 st071761 42 µM -0.103035879506741 0.434957521897068 no 1917 0.458967247378086 585 5147680 SGTC_2885 9057732 51.95 µM -0.105161473198007 0.434299502489671 no 1918 0.458123840547765 615 6471414 SGTC_1905 st060207 84.5 µM -0.105987423783342 0.434043862209309 no 1919 0.457796165173961 582 1948547 SGTC_1971 st069429 63.5 µM -0.106604329422765 0.433852941498272 no 1920 0.457551441889232 591 1246522 YGL099W LSG1 SGTC_3099 9120367 49.47 µM -0.106944189948864 0.433747767636809 no 1921 0.45741662784121 580 24824940 SGTC_3283 9109332 35.8195 µM -0.107076180267682 0.433706922934955 no 1922 0.457364271950639 584 17027281 SGTC_1641 st009299 47.1 µM -0.108418192725093 0.43329167441745 no 1923 0.456831985244901 599 4046054 SGTC_220 paclitaxel 373.376 µM -0.111020875535385 0.432486556714767 no 1924 0.455799896390057 626 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_492 tmb-8 126 µM -0.112053542371546 0.432167187514278 no 1925 0.455390476586229 621 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_712 r015-0009 80.6 µM -0.113331393533032 0.431772052404296 no 1926 0.454883914563604 604 6813872 YLR060W FRS1 SGTC_427 1354-0053 47.3 µM -0.114832002796783 0.431308123549834 no 1927 0.45428914113681 641 6813657 SGTC_1115 galangin 695.678 nM -0.114940568470719 0.431274563018109 no 1928 0.45424611458898 626 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2691 st077356 60.2 µM -0.119513767142376 0.429861319513546 no 1929 0.452434166803699 614 2839272 SGTC_157 1348-1695 65.819 µM -0.124285472350663 0.428387689772753 no 1930 0.450544624749093 606 5380510 SGTC_508 roscovitine 141 µM -0.129449139073929 0.426794136683504 no 1931 0.448501133688435 604 160355 A CDKinase inhibitor. SGTC_472 calcifediol 10 µM -0.129766587225973 0.426696208081963 no 1932 0.448375549435943 593 5283731 A vitamin D metabolite. SGTC_51 1013-0126 23.419 µM -0.131694194654789 0.426101663643224 no 1933 0.447613088759143 596 1627850 SGTC_2741 miltefosine 3.04 µM -0.131963882468588 0.426018495444881 no 1934 0.44750642973446 599 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.132695740937092 0.425792816446292 no 1935 0.447217005659035 599 115019 SGTC_2238 6671620 73.2395 µM -0.132864884155228 0.425740662177244 no 1936 0.447150119506341 612 729941 SGTC_1644 st010134 20.9 µM -0.135510075446853 0.424925203327072 no 1937 0.446104299340474 610 3818134 SGTC_301 4119-0100 24.5 µM -0.13582165918198 0.424829169453312 no 1938 0.445981134088733 627 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_346 4513-0042 7.16 µM -0.137930924673668 0.424179185932575 no 1939 0.445147504818932 618 2827372 SGTC_156 3474-0145 5.642 µM -0.139556519643681 0.423678389129112 no 1940 0.444505198314024 602 2265471 SGTC_1288 0973-0013 65.5 µM -0.140828585051622 0.423286590040256 no 1941 0.444002680249421 610 4315430 SGTC_2841 9004761 38.96 µM -0.143608232808856 0.422430716559348 no 1942 0.442904919604887 613 2991039 SGTC_634 1611-4317 11.2 µM -0.143740660450154 0.422389950243574 no 1943 0.442852631093174 617 2843522 SGTC_1618 st003135 44.5 µM -0.14565381442267 0.421801100921728 no 1944 0.442097341588322 607 1270615 SGTC_1604 st002052 72.4 µM -0.146269979951614 0.421611488594101 no 1945 0.441854131736879 603 6254834 YHR062C RPP1 SGTC_2006 4011487 200 µM -0.146388595454875 0.421574989185909 no 1946 0.441807314917214 614 45595294 SGTC_1849 st056239 19.2 µM -0.148636595551783 0.420883380421033 no 1947 0.440920197337828 614 5393181 SGTC_2989 9073649 71.4286 µM -0.149637390773339 0.420575559034333 no 1948 0.440525353361929 624 21367202 SGTC_1587 estradiol valerate 56.1 µM -0.150184606612672 0.420407268663742 no 1949 0.440309485145391 618 13791 A steroid. SGTC_3349 9149703 23.001 µM -0.150496815251417 0.420311258756758 no 1950 0.440186331592238 623 4910494 SGTC_3014 9081533 49.47 µM -0.153347661591829 0.419434790998823 no 1951 0.439062058300027 649 21367265 SGTC_938 3126-1755 342 µM -0.153919909375579 0.419258906439453 no 1952 0.438836442879789 603 1777771 SGTC_2797 7859098 81.82 µM -0.158349201562061 0.417898079237588 no 1953 0.437090819964359 605 972681 SGTC_1208 2323-2347 50.3 µM -0.159666788630718 0.417493461128937 no 1954 0.436571782020766 642 5412760 SGTC_1220 1838-0075 193 µM -0.161286168756405 0.416996285006819 no 1955 0.435934008187763 633 5529645 SGTC_336 4111-0029 111 µM -0.163024369878731 0.416462776589922 no 1956 0.435249623479688 638 3131175 SGTC_2291 7917025 104.35 µM -0.163387507012968 0.4163513378154 no 1957 0.43510666933455 623 2964612 SGTC_659 k018-0002 107 µM -0.164610057751341 0.415976213438163 no 1958 0.434625457137875 635 6797879 YHR007C ERG11 SGTC_1729 st035615 45.989 µM -0.164709817295418 0.415945606844935 no 1959 0.434586194720908 610 17385451 SGTC_3189 9110682 49.47 µM -0.166704647734111 0.415333692824944 no 1960 0.433801224176004 635 17122418 SGTC_1077 5-fluorocytosine 377 nM -0.167643368314518 0.415045811331622 no 1961 0.433431925506131 644 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3103 9120822 49.47 µM -0.167685083377148 0.415033019450565 no 1962 0.433415515880389 612 17141819 SGTC_188 3229-0966 278.469 µM -0.168028716977013 0.414927647989074 no 1963 0.433280343687899 621 5722370 SGTC_1070 indatraline 8.81 µM -0.168836585948911 0.414679947979409 no 1964 0.432962589991447 655 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2996 9066192 71.4286 µM -0.16900648496918 0.414627859700888 no 1965 0.4328957702555 635 6472854 SGTC_1572 epiandrosterone 68.9 µM -0.169369165481705 0.414516672773377 no 1966 0.432753137737663 605 441302 A steroid. SGTC_1936 st074407 74.3 µM -0.170907560140263 0.4140451235258 no 1967 0.432148225998335 609 809813 SGTC_2341 7987486 176.74 µM -0.170912791797322 0.41404352012752 no 1968 0.432146169130437 617 1258686 SGTC_1494 4358-1428 177 µM -0.174111929277005 0.413063317761714 no 1969 0.430888749094 654 1564571 SGTC_3267 9137951 49.47 µM -0.174133377953588 0.413056747798162 no 1970 0.430880321047078 604 16643986 SGTC_2504 purpurogallin 52.29 µM -0.175165145339468 0.412740734987433 no 1971 0.430474935427645 618 5281571 An antioxidant. SGTC_7 0192-1582 4.227 µM -0.17727685124521 0.412094131876184 no 1972 0.429645466414726 623 252616 SGTC_1044 1222-0021 1.78 µM -0.177936729545836 0.411892126367426 no 1973 0.429386332547965 641 4306703 SGTC_298 1391-0729 10 µM -0.178622809732019 0.411682124551792 no 1974 0.429116941476791 618 3237558 SGTC_1023 4482-3888 16 µM -0.178673055781916 0.411666745766087 no 1975 0.429097213537688 648 3303168 SGTC_2376 9072922 81.32 µM -0.180566038639088 0.411087460420161 no 1976 0.428354107443103 670 17087968 SGTC_2918 7977171 22.06 µM -0.180748487874335 0.411031638034058 no 1977 0.428282498862087 620 2236483 SGTC_1797 st048695 56.8 µM -0.184117016272307 0.410001323885475 no 1978 0.426960828811104 631 592262 YIL048W NEO1 SGTC_2511 berberine 10.47 µM -0.184206452483986 0.409973976931667 no 1979 0.426925748874975 630 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2032 5185112 25.99 µM -0.188334985413453 0.408712072154962 no 1980 0.425307030820076 615 5718189 SGTC_199 4063-0024 41.6 µM -0.188580749930677 0.408636982815899 no 1981 0.425210710711303 630 306215 SGTC_421 streptovitacin 30 mM -0.189834771670436 0.408253889201947 no 1982 0.424719303727216 645 91467 include heat shock SGTC_955 1216-0110 33 µM -0.191068983101734 0.407876933080881 no 1983 0.42423577391374 619 3619719 SGTC_2894 9048625 32.47 µM -0.196470673012835 0.406228142231155 no 1984 0.42212089243044 629 4092861 SGTC_3054 9094397 49.47 µM -0.197534380652786 0.405903655131848 no 1985 0.421704689780323 658 2598354 SGTC_1979 st071809 45.3 µM -0.197708531835388 0.405850535960211 no 1986 0.421636557021798 672 4976333 SGTC_1854 st056233 32.9 µM -0.19860527940445 0.405577039654117 no 1987 0.421285761757545 664 5393174 SGTC_941 3237-0776 460 µM -0.199921482807304 0.405175698297847 no 1988 0.420770994376498 629 760008 SGTC_2594 a-mangostin 100 µM -0.200844036363083 0.404894449438118 no 1989 0.420410264203059 657 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_409 arachidonic acid 100 µM -0.202441119534251 0.404407680276328 no 1990 0.419785942536577 641 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3085 9117376 49.47 µM -0.203509524036782 0.404082127696017 no 1991 0.419368401167886 634 16480349 SGTC_3265 9137266 49.47 µM -0.203943665722136 0.403949859736793 no 1992 0.419198760897021 640 17224265 SGTC_1395 3486-0190 4.35 µM -0.204271689543543 0.403849929503473 no 1993 0.419070595996201 661 6748079 SGTC_990 3985-0011 41.3 µM -0.205954264549077 0.403337443219043 no 1994 0.41841331848061 678 5399565 YGL099W LSG1 SGTC_3128 9127691 49.47 µM -0.206665740241964 0.403120788617302 no 1995 0.418135457535304 677 41316314 SGTC_430 0958-0115 16.4 µM -0.206878067204265 0.403056137755814 no 1996 0.418052542905947 651 6833180 SGTC_902 1120-0002 2.07 µM -0.208547661008455 0.402547860144919 no 1997 0.41740068625092 659 3280475 SGTC_2332 7982454 138.89 µM -0.210025203831025 0.40209818630869 no 1998 0.416824000953246 663 2981748 SGTC_2149 5554786 194.827 µM -0.210602212321336 0.401922615290042 no 1999 0.416598842924285 640 745063 YPR165W RHO1 SGTC_2925 9010536 32.5 µM -0.21067021050973 0.401901926236684 no 2000 0.416572310734004 637 2994177 SGTC_3160 9100216 49.47 µM -0.211306459451462 0.401708355166749 no 2001 0.416324071405154 635 17191039 SGTC_1296 1068-0102 11.9 µM -0.211775099796597 0.401565792410352 no 2002 0.416141247700334 664 767053 SGTC_800 3448-7362 155 µM -0.212880692563562 0.401229517454903 no 2003 0.415710011158195 640 15991913 SGTC_2064 5220758 200 µM -0.214395592835471 0.400768867150547 no 2004 0.415119289088126 644 788518 SGTC_1325 1431-0015 227 µM -0.217030521518457 0.399967968023995 no 2005 0.414092279521727 644 1103340 SGTC_228 caffeine 993.056 µM -0.218263144313358 0.399593450641644 no 2006 0.413612044378221 648 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2712 st079126 47.7 µM -0.218397640747977 0.399552591125522 no 2007 0.413559651793088 656 3152970 SGTC_1185 1319-0113 81.3 µM -0.218682535196602 0.399466044886295 no 2008 0.41344867730537 665 4672763 SGTC_628 1636-0253 16 µM -0.219055559031456 0.399352733860927 no 2009 0.413303384369856 665 4456143 SGTC_2570 licareol 100 µM -0.22020961522657 0.399002227442551 no 2010 0.412853954277301 673 443158 SGTC_1045 1348-1485 165 µM -0.22149115855384 0.398613096441221 no 2011 0.412355010055249 650 6810614 SGTC_3221 9128209 49.47 µM -0.221795354372388 0.398520744451636 no 2012 0.412236598036079 647 16460723 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.222435407823492 0.39832644670279 no 2013 0.411987475342719 651 77254 SGTC_3151 9099821 49.47 µM -0.222924995878862 0.398177841974203 no 2014 0.411796940980892 689 17174189 SGTC_2009 4012297 12.05 µM -0.223583794337916 0.397977900097935 no 2015 0.411540587353976 670 45595307 SGTC_1495 4469-0029 237 µM -0.224423299794731 0.397723153421969 no 2016 0.411213971206345 654 793680 SGTC_2445 5742597 35.57 µM -0.224824036328828 0.397601565888715 no 2017 0.411058083213702 644 1774255 SGTC_2467 5474540 200 µM -0.226128796647283 0.39720575733729 no 2018 0.410550624055545 634 5413519 SGTC_2748 diazoxide 86.69 µM -0.226179002623048 0.397190529100789 no 2019 0.410531100480104 630 3019 A potassium channel activatior. SGTC_842 0271-0008 11.1 µM -0.226665532770403 0.397042965224857 no 2020 0.410341915209372 637 1221709 SGTC_185 k048-0037 25.491 µM -0.227359973535996 0.396832367901793 no 2021 0.4100719208897 628 6827589 SGTC_2243 6634756 200 µM -0.228398378819922 0.396517515442167 no 2022 0.409668274831988 631 885676 SGTC_2394 5221648 200 µM -0.228657052259861 0.396439094156463 no 2023 0.409567738877233 656 788586 SGTC_1695 st026914 34.495 µM -0.228992761251877 0.396337324470342 no 2024 0.40943727117119 647 3289191 SGTC_366 0181-0206 4.31 µM -0.231332468211235 0.395628242267462 no 2025 0.408528262343426 668 274874 SGTC_2406 ethylparaben 405.7 µM -0.232531255501908 0.395265065999778 no 2026 0.408062707014147 688 8434 A possible steroid mimic. SGTC_1381 2324-0066 62.1 µM -0.233349267202704 0.395017299045377 no 2027 0.40774510232347 688 10885928 SGTC_2347 9049783 174.81 µM -0.233979055303715 0.394826571909748 no 2028 0.407500619416519 695 6467988 YPL169C MEX67 SGTC_1392 3455-1037 33.9 µM -0.234395750224219 0.394700392476809 no 2029 0.407338878796888 645 981132 SGTC_2811 7967822 32.47 µM -0.235319810010577 0.394420617259043 no 2030 0.406980260308083 641 2232244 SGTC_378 3970-0959 8.33 µM -0.235900191890094 0.394244924354883 no 2031 0.406755059672829 683 6615653 SGTC_3175 9106517 49.47 µM -0.235951501631892 0.394229392930863 no 2032 0.406735151873185 665 41468073 SGTC_2915 7971052 15.16 µM -0.237445141936852 0.393777342828229 no 2033 0.406155736331778 642 5741558 SGTC_137 0438-0332 85.389 µM -0.237517194063627 0.393755539871936 no 2034 0.406127790930447 683 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2449 5812982 45.77 µM -0.241806614157134 0.392458164767673 no 2035 0.404465006811565 643 776185 SGTC_1223 0764-0573 147 µM -0.241857959743194 0.392442642021334 no 2036 0.404445113192826 649 1609797 SGTC_1464 k208-0027 110 µM -0.243825389221412 0.391847979822886 no 2037 0.403683027953628 636 X1464 SGTC_1059 3448-6867 171 µM -0.244793747142584 0.391555383037342 no 2038 0.403308067853851 651 3934407 SGTC_1383 3049-0032 20.7 µM -0.244950244448201 0.391508101927693 no 2039 0.403247478505248 684 712864 SGTC_553 k007-0256 45.7 µM -0.244993289119822 0.391495097513003 no 2040 0.403230813778168 660 6287000 SGTC_2763 lisinopril 49.32 µM -0.245326949594984 0.391394297996488 no 2041 0.403101643224202 692 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_9 0092-0002 10.449 µM -0.246875724114267 0.390926505618744 no 2042 0.402502202134825 653 759368 SGTC_1633 st005664 67.9 µM -0.246998940841 0.390889295963925 no 2043 0.402454521885401 683 2063822 SGTC_2327 6189656 200 µM -0.247091767599231 0.390861264296202 no 2044 0.402418602371728 697 5349088 SGTC_2807 7945238 51.95 µM -0.248019362607895 0.390581181890792 no 2045 0.402059712786664 690 17148797 SGTC_2782 7736369 71.43 µM -0.250862289300204 0.389723129389428 no 2046 0.400960290513995 660 2950836 YOL077C BRX1 SGTC_2605 digitonin 300 nM -0.251067593828577 0.38966118509892 no 2047 0.400880924983811 647 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2647 atorvastatin 60.16 µM -0.25133556970968 0.389580335883415 no 2048 0.400777338451205 672 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_218 alverine citrate 93.75 µM -0.252341670266854 0.389276834671339 no 2049 0.40038849089318 681 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2963 9082507 9 µM -0.253191246171256 0.389020603411262 no 2050 0.400060215363123 693 16459611 SGTC_452 diindolylmethane 8 µM -0.255676626062258 0.388271292753689 no 2051 0.399100272550365 680 3071 Inhibits expression of several cancer promoting factors. SGTC_2193 5925765 200 µM -0.256457579742633 0.388035930775304 no 2052 0.398798765891281 671 877370 SGTC_142 0335-0849 62.6745 µM -0.256548119768225 0.388008646694313 no 2053 0.398763814557337 636 3889043 YPR107C YTH1 SGTC_3304 9125678 46.087 µM -0.256782314495136 0.387938075080797 no 2054 0.398673411699205 661 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3127 9126946 49.47 µM -0.258365201995725 0.387461189139785 no 2055 0.398062534937805 682 27243249 SGTC_1489 4065-0444 182 µM -0.259718623102057 0.387053570497095 no 2056 0.397540413156556 642 2877968 SGTC_2478 5763493 32.33 µM -0.260331266237079 0.386869097692179 no 2057 0.397304128424104 645 1365576 YLR208W SEC13 SGTC_1204 4049-0315 18.3 µM -0.260392642431239 0.386850618130966 no 2058 0.397280458875908 664 588402 SGTC_1454 4239-0054 42.6 µM -0.261036241487669 0.3866568544133 no 2059 0.39703227959556 696 1340767 SGTC_1800 st050079 29.0735 µM -0.261784516317491 0.386431612237742 no 2060 0.39674378854006 666 3645560 SGTC_1286 0929-0070 131 µM -0.261833065360238 0.386416999553822 no 2061 0.396725072816121 660 1420408 SGTC_1186 1319-0216 26 µM -0.263994403130338 0.38576662610996 no 2062 0.395892115735681 645 4565136 SGTC_3340 9146634 11.102 µM -0.264358979142802 0.385656952238638 no 2063 0.3957516586688 686 4907387 SGTC_2904 7225135 42.03 µM -0.266751069905926 0.384937576742709 no 2064 0.394830415002408 672 4446116 SGTC_2207 7258803 200 µM -0.267670073953998 0.384661308996615 no 2065 0.394476643505253 678 3666799 SGTC_748 act1.228 77.9 µM -0.268387302945387 0.384445738831816 no 2066 0.394200605951187 659 4421505 YNR035C ARC35 SGTC_1071 trifluoperazine 6.31 µM -0.270018095369113 0.383955721351194 no 2067 0.393573166206124 684 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_485 niflumic acid 177 µM -0.271888429140062 0.383393955293523 no 2068 0.392853904212383 669 4488 A COX2 inhibitor. SGTC_2252 omeprazole 400 µM -0.272604853180404 0.383178837850262 no 2069 0.392578490450119 664 4594 A proton pump inhibitor. SGTC_3004 9076122 71.4286 µM -0.272837769678733 0.383108908809874 no 2070 0.392488962307286 701 44782551 SGTC_777 1315-0167 517 µM -0.273384046784102 0.382944913761488 no 2071 0.392279007346098 655 4221767 SGTC_1575 cyproterone acetate 48 µM -0.274716831445685 0.382544893402987 no 2072 0.391766899448834 703 9880 An androgen receptor antagonist and liver toxin. SGTC_3059 1327-0034 3 µM -0.276289720701185 0.382072969547213 no 2073 0.39116277522754 659 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.277820296131893 0.38161390951106 no 2074 0.39057515511029 670 5377381 SGTC_586 0957-0265 8.15 µM -0.279750743635018 0.381035154710593 no 2075 0.389834372089873 677 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1219 1469-0211 33.1 µM -0.280373077475982 0.380848633525889 no 2076 0.389595645055026 699 6822282 SGTC_905 2-aminofluorene 215 µM -0.281586476495522 0.380485042414545 no 2077 0.389130305483587 650 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2306 7482397 179.52 µM -0.283307625365542 0.379969486807565 no 2078 0.38847051622462 711 891448 SGTC_2699 st077704 54.6 µM -0.284486651941832 0.379616442362322 no 2079 0.388018730926627 671 645852 SGTC_1872 amphotericin b 148 nM -0.285318918090665 0.379367291289092 no 2080 0.387699910211925 679 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2344 7990960 76.95 µM -0.289566226173725 0.378096579485926 no 2081 0.386074054041486 679 140813 SGTC_519 k048-0011 62.8 µM -0.289929921409166 0.377987830010461 no 2082 0.385934925155575 666 6836379 SGTC_1111 tnp00062 510.699 nM -0.290062371345454 0.377948228205281 no 2083 0.385884261068476 663 676306 SGTC_542 3381-0244 89.3 µM -0.290110282959021 0.377933903211223 no 2084 0.385865934637059 701 1112843 SGTC_2297 7971671 152.32 µM -0.290722044594941 0.37775100862743 no 2085 0.385631955161253 702 909016 SGTC_3186 9110464 49.47 µM -0.293164535853591 0.377021065645587 no 2086 0.384698195015384 682 17018021 SGTC_1878 temozolomide 1 mM -0.293230722263313 0.377001291817496 no 2087 0.384672901344735 664 5394 DNA alkylating agent. SGTC_2515 chrysin 20.77 µM -0.297117110449744 0.375840763087813 no 2088 0.383188550832052 675 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2336 9001819 198.65 µM -0.297454508014068 0.375740064346327 no 2089 0.383059767166238 696 2989602 SGTC_2459 5811157 9.22 µM -0.298572644491783 0.375406408963171 no 2090 0.382633070194656 670 2870684 YBR192W RIM2 SGTC_2750 bromebric acid 70.15 µM -0.299725859823024 0.375062383549989 no 2091 0.382193135832439 705 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1671 st016596 74.5 µM -0.301199834790458 0.374622814321942 no 2092 0.381631057898372 659 2829167 SGTC_966 1300-0360 30.2 µM -0.303106443085766 0.374054466720662 no 2093 0.380904372059626 687 70588 SGTC_73 0327-0325 16.231 µM -0.303486776912816 0.373941124368442 no 2094 0.3807594615461 681 53298 SGTC_1056 3448-1962 115 µM -0.303624687706425 0.373900028602508 no 2095 0.380706920458851 676 715507 SGTC_3353 9151644 39.2805 µM -0.304064193419313 0.373769070725096 no 2096 0.380539492786172 688 4909158 SGTC_2835 9006588 71.43 µM -0.304069938349785 0.373767359026048 no 2097 0.380537304429497 672 2345538 SGTC_1732 st034308 51.822 µM -0.305057162987292 0.373473252959733 no 2098 0.380161308032251 653 830119 SGTC_2037 5169046 200 µM -0.306343277435462 0.373090214574769 no 2099 0.379671645723209 687 5718022 SGTC_944 3370-0224 231 µM -0.307632878675319 0.372706263643356 no 2100 0.37918084955912 675 4580514 SGTC_2891 9063876 19.48 µM -0.31008470023985 0.37197663568995 no 2101 0.378248273337379 674 6472478 SGTC_732 3970-1727 52.7 µM -0.31197800756208 0.371413528046042 no 2102 0.3775286186004 709 1275699 SGTC_264 promethazine 12.5 mM -0.312883689559907 0.371144257218456 no 2103 0.377184514865436 681 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_854 0422-0053 192 µM -0.316104392273614 0.370187212914442 no 2104 0.3759616364995 674 3596728 SGTC_3231 9132313 49.47 µM -0.317031037578361 0.369912005185921 no 2105 0.37561002574915 696 4905967 SGTC_1929 genistein trimethyl ether 50.5 µM -0.317270434361529 0.369840916693616 no 2106 0.375519204659277 667 136420 SGTC_1499 4480-0877 67.3 µM -0.317280357724644 0.36983797006278 no 2107 0.375515440134938 663 2861909 SGTC_2335 9018011 154.17 µM -0.31824737496276 0.369550861876015 no 2108 0.375148649643852 683 6458208 SGTC_273 hydroxyurea 18.1 mM -0.319872581179318 0.369068500743407 no 2109 0.374532461883811 683 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2866 9034245 58.44 µM -0.321630097421 0.368547101977083 no 2110 0.373866469985679 687 6462273 SGTC_2908 7930301 100 µM -0.322187366059481 0.368381828695314 no 2111 0.373655377521072 701 2223178 SGTC_1862 st057513 3.81 µM -0.322596658104632 0.36826045743404 no 2112 0.373500362487366 678 5393163 SGTC_705 1124-0212 310 µM -0.323765975787137 0.36791378101108 no 2113 0.373057608618762 697 9554485 SGTC_981 1488-1094 54.9 µM -0.324535673112036 0.36768564173195 no 2114 0.372766259601879 664 3449522 SGTC_867 0518-0118 155 µM -0.327317255161463 0.366861566915093 no 2115 0.371713971437825 704 6848158 SGTC_1650 st011916 45.8 µM -0.327878912646008 0.366695243883629 no 2116 0.371501609216305 720 242528 SGTC_39 0986-0283 58.349 µM -0.329483251589547 0.366220290641436 no 2117 0.37089522559648 671 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2256 7954252 200 µM -0.330092746980076 0.366039907485969 no 2118 0.370664941723796 714 2972920 SGTC_2030 5175110 200 µM -0.331363027500398 0.365664056911046 no 2119 0.370185144302227 731 2831986 SGTC_2216 7189485 200 µM -0.335163171621263 0.364540441381217 no 2120 0.368751000844107 686 731273 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.335388139934967 0.36447395977036 no 2121 0.368666156685415 684 4330530 SGTC_1624 st003710 6.25 µM -0.335861246739076 0.364334162706227 no 2122 0.36848775089883 732 24207033 SGTC_2829 7992743 58.44 µM -0.33705337569117 0.363981983771608 no 2123 0.368038331881412 715 16462845 SGTC_2928 9011484 9.79 µM -0.33741420687534 0.363875409591996 no 2124 0.367902338208482 708 2994751 SGTC_879 0831-1030 162 µM -0.338250731288717 0.36362837638468 no 2125 0.367587124213434 701 1549252 SGTC_726 3448-4391 34.2 µM -0.33838096860107 0.363589921228363 no 2126 0.367538057006672 729 1356692 SGTC_1060 3448-7350 82 µM -0.33876140085406 0.363477598912416 no 2127 0.367394740667079 719 570178 SGTC_1556 plumbagin 1.48 µM -0.341604884260501 0.362638434996052 no 2128 0.366324130499746 697 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1776 st049249 45.9 µM -0.343902349333167 0.361960892444563 no 2129 0.365459862501743 681 1822314 SGTC_3270 9137563 49.47 µM -0.344264812372372 0.361854038358349 no 2130 0.365323572195567 670 17015724 SGTC_1504 k297-0033 30 µM -0.344481661659112 0.361790116347198 no 2131 0.365242042478288 672 4388117 SGTC_2272 7805186 180 µM -0.345415503926236 0.361514885939982 no 2132 0.364891011591029 746 2956062 YPR165W RHO1 SGTC_1895 st058434 18.3 µM -0.345476762879468 0.36149683365179 no 2133 0.364867988332046 734 5393175 SGTC_590 k048-0076 22.4 µM -0.346141364941088 0.361301003118342 no 2134 0.364618238947259 713 6832814 SGTC_2373 9071805 200 µM -0.350741376248553 0.359946570122004 no 2135 0.362891190659197 735 10149009 SGTC_1876 myriocin 605 nM -0.351209447035008 0.359808848967062 no 2136 0.362715611651731 730 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1152 3909-8331 15.9 µM -0.351690062430296 0.359667455731863 no 2137 0.362535357042065 691 16001939 SGTC_856 0433-0016 11.3 µM -0.353443791762412 0.35915168551515 no 2138 0.36187788023966 703 3911780 SGTC_1622 st003707 19.4 µM -0.355646468999405 0.358504243738623 no 2139 0.361052669339099 708 10140899 SGTC_2878 9043973 25.97 µM -0.3593317555437 0.357421922383397 no 2140 0.359673460509616 700 6465167 SGTC_2444 5485484 36.41 µM -0.359411840994979 0.357398415004327 no 2141 0.359643508943103 736 6790631 SGTC_1969 st069479 40.1 µM -0.359671075812877 0.357322325854092 no 2142 0.359546562303693 723 3895485 SGTC_2635 hydroquinidine 100 µM -0.359744390927777 0.357300807841489 no 2143 0.359519146121405 690 442912 An experimental heart treatment. SGTC_1944 st076371 56.9 µM -0.36030466087437 0.357136383398589 no 2144 0.359309657098604 696 24208455 SGTC_83 0170-0301 39.027 µM -0.360811973161419 0.356987523514821 no 2145 0.359120005808201 684 3089716 SGTC_3337 9144342 33.5465 µM -0.36105479917983 0.356916279142936 no 2146 0.359029241128186 673 17682949 SGTC_1747 st037496 66.6 µM -0.368718679086991 0.354670297181947 no 2147 0.356168712193425 689 723305 SGTC_390 dec-rvkr-cmk 16.7 µM -0.369195511696093 0.35453072213562 no 2148 0.355991000543153 700 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2167 5876490 200 µM -0.372011902462835 0.353706727203019 no 2149 0.354941993731251 741 686534 SGTC_2670 beta-carotene 100 µM -0.372079800003989 0.3536868707754 no 2150 0.354916717809577 693 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_266 formosanin C 406 nM -0.372180138387701 0.353657527851706 no 2151 0.354879366445953 701 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2676 harmalol 100 µM -0.373345599626113 0.35331676449743 no 2152 0.354445621126526 694 5459187 A monoamine oxidase inhibitor SGTC_664 1222-0054 14.9 µM -0.379974237302661 0.35138089336175 no 2153 0.351982269547701 709 6813991 SGTC_1251 0490-5699 265 µM -0.381843281029137 0.350835738957221 no 2154 0.351288806604553 734 3883818 SGTC_1051 3253-3903 78 µM -0.382586437179294 0.350619063681701 no 2155 0.351013214047554 703 5509239 SGTC_2899 9053889 58.44 µM -0.38382045318024 0.350259380217755 no 2156 0.350555763793921 727 6470052 SGTC_1468 k284-1086 134 µM -0.384433478992665 0.350080749084043 no 2157 0.350328595361855 714 15996457 SGTC_602 3130-1533 38.1 µM -0.384566857637237 0.350041887937187 no 2158 0.350279176443603 726 720941 SGTC_1299 1079-1439 3.74 µM -0.385305756127483 0.349826631236183 no 2159 0.35000544868854 732 323161 SGTC_2092 5303694 80.6725 µM -0.385688562070772 0.349715130771302 no 2160 0.349863667404485 711 1963699 SGTC_1961 st076550 68.7 µM -0.387122069359096 0.349297706156893 no 2161 0.349332919989782 713 1579337 SGTC_1230 0170-0365 3.77 µM -0.39015874758673 0.348414054748353 no 2162 0.348209581903526 704 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.395698761646876 0.346804071303645 no 2163 0.346163634580247 713 1241132 A phosphatase inhibitor. SGTC_2043 5101342 149 µM -0.396073884032592 0.346695156523511 no 2164 0.346025261875156 716 678451 SGTC_2158 5657123 3.6195 µM -0.39673677467881 0.346502720747037 no 2165 0.345780789358192 766 2858827 SGTC_1344 1488-0097 29.1 µM -0.396739840320877 0.346501830889491 no 2166 0.34577965890585 727 747966 SGTC_3272 9137413 49.47 µM -0.396981855634187 0.346431584281396 no 2167 0.345690420348747 748 17614870 SGTC_1145 3546-0597 10.2 µM -0.397166235373154 0.34637807033932 no 2168 0.345622439570225 701 875334 SGTC_1191 1487-1166 10.6 µM -0.398193869159013 0.346079868522556 no 2169 0.345243642411378 756 3955771 SGTC_1205 4161-2785 76 µM -0.399245004518927 0.345774945665654 no 2170 0.34485634264336 744 3498106 SGTC_737 1950-0117 57.9 µM -0.400298641263103 0.345469397548645 no 2171 0.344468284300138 729 5393513 SGTC_86 0417-1630 471.922 µM -0.400443888620576 0.345427284606997 no 2172 0.344414801982183 720 3634867 SGTC_439 amiodarone 34.4 µM -0.400625143339706 0.345374734393744 no 2173 0.344348065561149 714 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_727 3032-0951 202 µM -0.400880224152428 0.345300785224135 no 2174 0.344254155219455 725 3652836 SGTC_2298 7976326 193.81 µM -0.403636230999503 0.344502182532016 no 2175 0.343240119431618 713 2235818 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.406576337762141 0.343650997112185 no 2176 0.342159589595949 720 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1524 corynanthine 62.1 µM -0.407436581905309 0.343402098849667 no 2177 0.341843681748753 753 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_171 k064-0041 9.68 µM -0.409684105169051 0.342752133607302 no 2178 0.34101884570517 698 53325 SGTC_865 0488-0499 301 µM -0.412472588213818 0.341946373985236 no 2179 0.339996534214827 741 9634651 SGTC_1920 st075728 45.7 µM -0.413273273008743 0.341715141002369 no 2180 0.339703204650044 743 3400306 SGTC_739 1486-1183 203 µM -0.415504593678034 0.341071062469569 no 2181 0.338886276523595 724 4346692 SGTC_576 1073-0113 22.7 µM -0.41633176072487 0.340832415290552 no 2182 0.338583627394687 768 5439563 SGTC_431 k089-0097 107 µM -0.418601161343955 0.340177994465896 no 2183 0.337753820349809 735 5499420 SGTC_2014 4013930 200 µM -0.421418906898705 0.339366118591337 no 2184 0.336724607695637 757 64556 SGTC_2888 9058547 12.99 µM -0.423794296802467 0.338682277041815 no 2185 0.33585791889283 714 16476514 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.424689684235278 0.338424645312494 no 2186 0.335531452400505 764 6710655 SGTC_2317 5986382 200 µM -0.426651004322003 0.337860574861506 no 2187 0.334816771068596 750 877883 SGTC_2991 9074669 71.4286 µM -0.426962775099243 0.337770943904299 no 2188 0.334703220573081 765 17333109 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.427418579696995 0.337639921232075 no 2189 0.334537238510419 735 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3111 9122088 49.47 µM -0.429632756330056 0.337003728393563 no 2190 0.333731402656878 737 16876704 SGTC_2698 st077697 67.5 µM -0.429774359457534 0.336963057818761 no 2191 0.333679893110348 732 3154499 SGTC_3039 9090270 49.47 µM -0.431043787715255 0.336598543869532 no 2192 0.333218266060304 719 17173750 SGTC_975 1335-0046 28.5 µM -0.431633094434345 0.336429377690441 no 2193 0.333004050709063 765 16486740 SGTC_2187 6125751 200 µM -0.435647828504026 0.335277792077979 no 2194 0.331546131809512 734 874498 SGTC_844 0330-0132 15.3 µM -0.436626747631286 0.334997233150401 no 2195 0.33119103068771 737 2828079 SGTC_2950 9072895 21.46 µM -0.440188858960653 0.333977107336186 no 2196 0.329900164085047 739 17332245 SGTC_785 1270-0111 65.3 µM -0.441150285964268 0.333701981327576 no 2197 0.329552100477778 707 6741994 SGTC_2025 5147754 141 µM -0.441654951283613 0.333557599937852 no 2198 0.329369456496956 728 315777 YLR208W SEC13 SGTC_1333 1482-0047 286 µM -0.444645760119821 0.332702455935354 no 2199 0.328287886254933 754 3811116 SGTC_53 0973-0023 39.979 µM -0.445071720343917 0.332580734338114 no 2200 0.328133962438335 756 674768 SGTC_1702 st027038 51 µM -0.447241983337572 0.331960838314508 no 2201 0.327350175692246 731 5521182 SGTC_1336 1486-0901 104 µM -0.447739448882382 0.331818811056845 no 2202 0.327170623885082 717 5006114 SGTC_1117 retinoic acid 1.10837 µM -0.44842732593763 0.331622460805377 no 2203 0.32692241213491 758 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_153 4077-0274 519.67 µM -0.450011905336415 0.331170328489844 no 2204 0.326350928104643 682 3121976 SGTC_1178 0988-0033 191 µM -0.451904657909985 0.330630586774097 no 2205 0.325668834363551 720 5392207 SGTC_425 3825-7017 13.1 µM -0.452754163674859 0.330388454119813 no 2206 0.325362886342331 748 3397440 SGTC_1818 st052136 56.3 µM -0.453778870480208 0.330096478788611 no 2207 0.324993996536088 738 674169 SGTC_2523 spermine 47.74 µM -0.454513994886013 0.329887079474778 no 2208 0.324729460706884 729 1103 A DNA binding polyamine. SGTC_1365 1672-3266 55.4 µM -0.457137812843379 0.329140123022067 no 2209 0.323785996541208 750 6415873 SGTC_501 nsc-95397 161 µM -0.46160941243152 0.327868706278779 no 2210 0.322180721759013 754 262093 SGTC_1399 3562-5772 25 µM -0.461991459960313 0.327760170310305 no 2211 0.322043722343106 744 23847490 SGTC_889 0919-1524 82.7 µM -0.462755434059622 0.327543176379666 no 2212 0.321769839418508 743 3905452 SGTC_2493 resveratrol 26.09 µM -0.463269533030688 0.327397188034298 no 2213 0.321585590626309 728 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_81 0411-0046 9.971 µM -0.463915476054458 0.32721379743526 no 2214 0.321354152225846 758 12925265 SGTC_1742 st038235 28.8875 µM -0.464412171910674 0.327072808171505 no 2215 0.321176235553031 769 564103 YBR002C RER2 SGTC_1718 roemerine 11.9335 µM -0.465199212918966 0.326849453716039 no 2216 0.320894401161353 745 235224 An aporphine alkaloid with mutagenic activity. SGTC_1248 0469-0687 58.6 µM -0.466033855429796 0.326612658189463 no 2217 0.320595633694483 754 4017482 SGTC_2946 9065502 71.43 µM -0.467544300479363 0.326184309049936 no 2218 0.320055252399614 735 16489101 SGTC_75 0159-0059 199.013 µM -0.469232378163975 0.325705856055622 no 2219 0.319451772187359 797 5377270 SGTC_2331 7980721 200 µM -0.469343147185396 0.325674470741819 no 2220 0.319412189449544 727 2981221 SGTC_685 1278-0033 54.9 µM -0.469621678575382 0.325595557069735 no 2221 0.31931266678922 747 3590572 SGTC_341 1486-1430 230 µM -0.470633613341254 0.325308920938542 no 2222 0.318951199764692 759 2054753 YPL210C SRP72 SGTC_2130 NSC 7 2.4545 µM -0.474227128935005 0.324291873553061 no 2223 0.317668974805375 752 21448 SGTC_2198 6589944 200 µM -0.474358558321465 0.324254700799019 no 2224 0.317622119964157 732 5290268 SGTC_761 k216-0224 480 µM -0.474815116197345 0.324125584131008 no 2225 0.317459378863133 798 1340404 SGTC_3093 9117344 49.47 µM -0.474902795609618 0.324100790410339 no 2226 0.317428129372615 715 24824913 SGTC_1148 3909-7663 27.7 µM -0.476108608933337 0.323759893323408 no 2227 0.31699850204233 777 4084526 SGTC_621 3584-0052 32.1 µM -0.478020971569998 0.323219549904918 no 2228 0.31631763933508 768 2273927 SGTC_3344 9148862 3.898 µM -0.478166521211502 0.323178439696662 no 2229 0.316265844426313 778 4905352 SGTC_278 4092-0821 23.9 µM -0.480557966924601 0.322503290114488 no 2230 0.315415347697474 773 877900 SGTC_1712 st032288 53.4 µM -0.481221560364658 0.32231604892701 no 2231 0.315179519481118 755 2883011 SGTC_1162 k048-0130 20.1 µM -0.482557179905621 0.321939323862594 no 2232 0.31470509461321 764 6797406 SGTC_539 4859-0462 2.54 µM -0.482809568744299 0.321868155563837 no 2233 0.314615477996803 732 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_175 3793-3120 23.7 µM -0.48651012724486 0.320825427921763 no 2234 0.313302763405228 806 5322297 SGTC_2371 9071574 200 µM -0.487120412809004 0.32065359965435 no 2235 0.313086500702083 761 45596039 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.488118290764137 0.320372726033254 no 2236 0.312733028057292 774 551469 SGTC_1967 st070177 51.4 µM -0.488962482945697 0.32013519079782 no 2237 0.312434129046037 784 5729214 SGTC_192 3455-0609 60.9 µM -0.492870968547921 0.319036399361653 no 2238 0.311051880778547 744 3769639 SGTC_2916 7875993 68.79 µM -0.493939447843245 0.318736294111252 no 2239 0.31067447204338 799 1299250 SGTC_1398 3558-0053 112 µM -0.494021807483646 0.318713166576345 no 2240 0.31064538919632 734 4532369 SGTC_407 eburnamonine 100 µM -0.49476877516506 0.318503441706783 no 2241 0.310381673921445 768 3195 SGTC_2803 7707263 71.43 µM -0.496315023122176 0.318069489047991 no 2242 0.309836084287351 741 2199229 SGTC_2598 perillyl alcohol 100 µM -0.4965872869206 0.317993104367649 no 2243 0.309740060011471 743 10819 An apoptosis inducer. SGTC_2374 9071832 200 µM -0.497359310539819 0.317776552213185 no 2244 0.309467846871392 772 17381698 SGTC_1594 piperine 70.1 µM -0.497406376263338 0.317763352321004 no 2245 0.309451255021277 763 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1141 3253-0389 52.6 µM -0.497888217079797 0.317628230215282 no 2246 0.309281416375002 778 5402031 SGTC_1317 1273-0028 910 nM -0.499141892959969 0.317276777077003 no 2247 0.308839713244239 751 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2533 agelasine 13.65 µM -0.49945137552429 0.317190042653076 no 2248 0.308730716865961 756 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1418 3966-3099 2.4 µM -0.499987873679366 0.317039709481544 no 2249 0.308541807995966 759 740335 SGTC_945 3381-0768 11.3 µM -0.5001038075521 0.317007227396445 no 2250 0.30850099263475 769 1126236 YIL048W NEO1 SGTC_2437 5741531 144.16 µM -0.501410956257886 0.316641091116934 no 2251 0.308040965296238 775 2262990 SGTC_1720 st037298 9.481 µM -0.50245422099783 0.316348998361038 no 2252 0.307674023398274 794 597396 SGTC_1919 st067113 52.3 µM -0.503854464708166 0.315957138856028 no 2253 0.307181825514373 749 1268243 SGTC_1303 1160-0052 261 µM -0.504766488810536 0.315702019193593 no 2254 0.306861427720307 765 3562476 SGTC_2188 6126565 140.678 µM -0.505391203676656 0.31552731893291 no 2255 0.30664204792221 754 874518 SGTC_219 mitoxanthrone 164.414 µM -0.506344699625574 0.315260755182834 no 2256 0.306307344302569 772 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2708 st078559 56 µM -0.507765437004211 0.314863745639851 no 2257 0.305808925705803 758 17250902 SGTC_523 1934-0222 13.7 µM -0.508330549912723 0.314705890431504 no 2258 0.30561077445652 789 1361595 SGTC_2223 6903751 107.57 µM -0.509069476934489 0.314499534124053 no 2259 0.305351762879016 768 5598863 SGTC_2506 ethyl hematommate 54.16 µM -0.509764035955806 0.314305621060173 no 2260 0.30510839215877 761 3940691 An allergen. SGTC_984 1492-0255 2.91 µM -0.511046263623524 0.313947772149833 no 2261 0.30465933107734 768 1585198 SGTC_2667 digitoxin 100 µM -0.512356664118339 0.313582241355478 no 2262 0.304200707256946 745 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2520 obtusaquinone 4.71 µM -0.51345979653753 0.313274668955165 no 2263 0.30381486328547 772 5967872 SGTC_1036 k216-0215 33.5 µM -0.51366778953441 0.313216691451845 no 2264 0.303742137791912 749 622330 SGTC_8 0354-0001 70 µM -0.514024215287994 0.313117349441188 no 2265 0.303617530321573 761 4993152 SGTC_1235 benzylparaben 21.5 µM -0.514225851042546 0.313061156081903 no 2266 0.303547047989812 781 7180 SGTC_2759 disulfiram 3.38 µM -0.514285492422564 0.313044535608312 no 2267 0.303526201581973 747 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2976 9009005 19.48 µM -0.514365622531103 0.313022206066597 no 2268 0.303498194770503 764 2993148 SGTC_1761 st044296 37 µM -0.51440804169061 0.313010385564121 no 2269 0.303483369032931 761 1826700 SGTC_2150 5556613 200 µM -0.515184205824859 0.312794133984551 no 2270 0.303212152386493 763 743190 SGTC_342 k048-0088 23.3 µM -0.51567371330818 0.312657782589262 no 2271 0.303041158517362 729 6820570 SGTC_1691 st019933 84.6 µM -0.516092299249553 0.312541206588929 no 2272 0.302894973063449 778 6176082 SGTC_2914 7968218 45.32 µM -0.520276125435906 0.311377044943109 no 2273 0.301435566809297 764 2977111 SGTC_2639 lactacystin 53 µM -0.52062528543063 0.311279975177818 no 2274 0.301313915692517 750 3870 A proteasome inhibitor. SGTC_1930 st074634 34.3 µM -0.522920594879469 0.310642184445774 no 2275 0.300514756028189 793 684253 YOR116C RPO31 SGTC_3182 9108849 49.47 µM -0.52666029495001 0.309604263847474 no 2276 0.299214756434151 758 17133045 SGTC_3260 9137109 49.47 µM -0.526724859354504 0.309586357863968 no 2277 0.299192334892533 773 17478346 SGTC_2201 6605497 169.863 µM -0.527017798099727 0.309505121309512 no 2278 0.299090614449884 773 670741 SGTC_1900 st060200 72.8 µM -0.528113812217463 0.309201261812209 no 2279 0.298710172371822 750 688945 SGTC_420 mitomycin C 81.9 mM -0.529165800870891 0.308909730653394 no 2280 0.298345219211098 752 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2181 6316240 54.2555 µM -0.530686984497528 0.30848838721861 no 2281 0.297817853414386 762 12779990 SGTC_1910 st062352 60.4 µM -0.532014176128984 0.308120982331621 no 2282 0.29735808858055 744 2245730 SGTC_1853 st056710 91.2 µM -0.532167916715018 0.308078434921573 no 2283 0.297304850832156 773 269167 SGTC_3305 9127027 53.8275 µM -0.534650175351205 0.307391831965817 no 2284 0.296445890413093 771 41905295 SGTC_1834 st055981 52.8 µM -0.53543547219987 0.307174755941065 no 2285 0.296174383436835 772 471719 YDL150W RPC53 SGTC_898 1000-0849 28.3 µM -0.53589736984854 0.30704710722872 no 2286 0.296014741161975 780 6751807 SGTC_671 0560-0003 407 µM -0.535913860400771 0.307042550379122 no 2287 0.296009042384479 760 3238678 SGTC_2998 9066762 71.4286 µM -0.535985551577962 0.307022740236053 no 2288 0.295984268052626 779 4945196 SGTC_2684 capsaicin 100 µM -0.537534433247614 0.306594881453082 no 2289 0.295449253366639 785 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_537 1334-0398 209 µM -0.538644886604524 0.306288294996857 no 2290 0.295065954571189 771 5846986 SGTC_2323 6148992 148.28 µM -0.538653799339634 0.306285834816886 no 2291 0.295062879060163 765 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_384 k007-0144 5.16 µM -0.538973864287351 0.306197493161159 no 2292 0.294952444268298 767 6824886 SGTC_837 0091-0265 12.5 µM -0.539565110918244 0.306034331834884 no 2293 0.294748491404395 776 759367 SGTC_105 0111-0055 734.78 µM -0.539889467385107 0.305944838268965 no 2294 0.29463663098846 778 5179370 SGTC_84 0443-0269 128.823 µM -0.542457951502043 0.305236574262857 no 2295 0.293751533366149 776 6150058 SGTC_771 0250-0039 27.3 µM -0.544250252275047 0.304742775597754 no 2296 0.293134637673479 778 3005115 SGTC_2696 st077691 74.316 µM -0.544312134582868 0.304725732682433 no 2297 0.293113349008338 792 757133 SGTC_2761 levamisole 97.89 µM -0.545491642646472 0.304400967155026 no 2298 0.292707713445824 793 26879 An alkaline phosphatase inhibitor. SGTC_1309 pyrazolanthrone 13.4 µM -0.545546398317734 0.304385894481735 no 2299 0.292688889177346 785 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1445 4239-0156 97.7 µM -0.545999560633229 0.304261164587264 no 2300 0.292533119613261 792 4008346 SGTC_1120 ficusin 1.78878 µM -0.547290042175485 0.30390609296145 no 2301 0.292089741974344 793 6199 A DNA cross-linker. SGTC_2875 9039966 71.43 µM -0.547422508244883 0.303869655831352 no 2302 0.29204424760567 776 6463691 SGTC_660 4031-1742 102 µM -0.547937472562033 0.303728024323568 no 2303 0.291867418743528 767 6738706 SGTC_1020 4335-0961 93.3 µM -0.548204955837115 0.303654469572666 no 2304 0.291775589805399 790 669075 SGTC_311 1315-0136 58 µM -0.548590445018599 0.303548478576929 no 2305 0.291643272274296 777 6759207 SGTC_450 aminopyrene 156 nM -0.548968543183849 0.303444535807695 no 2306 0.29151351885763 786 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2086 5274770 176.623 µM -0.549831116951074 0.303207465641299 no 2307 0.291217606881849 769 689278 SGTC_330 1488-0319 80.1 µM -0.551173418879038 0.302838711582491 no 2308 0.290757399914742 774 6846614 SGTC_2871 9038510 12.99 µM -0.552530693675225 0.302466048526538 no 2309 0.290292405585909 814 4945164 SGTC_527 4476-4215 268 µM -0.55276238862542 0.302402453258619 no 2310 0.290213063079753 762 4418754 SGTC_1433 4060-0023 7.6 µM -0.553758099190168 0.302129220466939 no 2311 0.289872203839427 767 3840627 SGTC_749 1000-0129 128 µM -0.554539663892151 0.301914829083109 no 2312 0.289604784256603 797 708470 SGTC_2001 4023502 57.655 µM -0.555017130641921 0.301783888595356 no 2313 0.289441471608738 769 108941 YCR052W RSC6 SGTC_2804 7954240 19.48 µM -0.55527272151729 0.301713805841812 no 2314 0.289354067128432 765 828705 SGTC_3184 9108758 49.47 µM -0.555754969115459 0.301581593982734 no 2315 0.289189186571359 779 902885 SGTC_3347 9188721 44.724 µM -0.557503416685762 0.301102462433643 no 2316 0.288591762666259 792 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1446 4239-0190 62 µM -0.557554023535155 0.301088599618893 no 2317 0.288574479564271 791 1340085 SGTC_706 4262-0057 46.9 µM -0.557822535149445 0.301015050617599 no 2318 0.288482786428106 785 883298 SGTC_2398 5228213 48.84 µM -0.561974071646132 0.299878920273394 no 2319 0.287066842459071 788 80771 YMR134W ERG29 SGTC_251 melphalan 456.522 µM -0.562699847933338 0.299680500187536 no 2320 0.286819643912349 781 460612 A DNA alkylator. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.565443863000975 0.298930851587858 no 2321 0.285885948565636 773 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_44 0929-0055 61.211 µM -0.56629113084395 0.298699555279715 no 2322 0.28559794429617 751 1379590 SGTC_591 4299-0174 154 µM -0.566589602105865 0.298618094760888 no 2323 0.285496520496629 789 5509088 SGTC_1968 st069590 43.6 µM -0.566656963335798 0.298599711538265 no 2324 0.285473632785759 786 6384066 SGTC_618 k072-0232 33.2 µM -0.568176374295931 0.298185193359132 no 2325 0.284957606050812 791 5872756 YGL099W LSG1 SGTC_1554 st069299 38.7 µM -0.569590521775723 0.297799628296522 no 2326 0.284477729270895 762 24207999 SGTC_1217 1183-1422 255 µM -0.572071107126621 0.297123850505837 no 2327 0.283636901183568 776 2849664 SGTC_2021 4019055 173 µM -0.572371248115853 0.297042131645261 no 2328 0.283535245113407 807 44827708 YER133W GLC7 SGTC_2595 hexamethylquercetagetin 100 µM -0.573094873899164 0.296845153601186 no 2329 0.283290228931386 809 386331 SGTC_2079 5212404 121 µM -0.573977885778065 0.296604870114395 no 2330 0.282991383015554 779 758462 SGTC_2764 methyldopa 94.69 µM -0.574137505815694 0.296561444128144 no 2331 0.282937377478831 804 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2123 5259487 200 µM -0.574443878929384 0.296478100883834 no 2332 0.28283373365509 777 2173474 SGTC_2977 9011197 71.43 µM -0.575075328145163 0.296306360455224 no 2333 0.282620176463116 806 2704722 SGTC_1571 st070080 73.4 µM -0.57704398453618 0.295771221858589 no 2334 0.281954871485094 784 4315245 SGTC_734 2023-0417 80 µM -0.578057977613217 0.295495762140326 no 2335 0.281612488405106 807 3935732 SGTC_2268 7933382 153.85 µM -0.578262790625231 0.295440137294112 no 2336 0.281543355958749 767 935025 YOR257W CDC31 SGTC_2898 9056270 58.44 µM -0.578678246302512 0.295327319131729 no 2337 0.281403148478537 764 19154699 SGTC_1567 st069303 68.4 µM -0.581438494691373 0.294578269793445 no 2338 0.280472479787694 798 5581319 SGTC_3243 9134147 49.47 µM -0.582354713893482 0.294329829057422 no 2339 0.280163889257141 807 24282180 SGTC_210 3551-0445 56.827 µM -0.582924198192412 0.294175457257726 no 2340 0.279972164976313 810 2865180 YOR207C RET1 SGTC_1522 st012842 45.6 µM -0.584167471705432 0.293838569468705 no 2341 0.2795538219791 794 3491067 YOR116C RPO31 SGTC_3219 9131112 49.47 µM -0.584281376163102 0.293807713890685 no 2342 0.279515510008944 788 17612988 YMR079W SEC14 SGTC_784 4579-0127 173 µM -0.584484500582535 0.293752693238067 no 2343 0.279447195071148 806 1948547 SGTC_1569 carminic acid 40.6 µM -0.58494336434367 0.293628417594706 no 2344 0.279292899567455 784 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1708 st033234 31.827 µM -0.586461276252624 0.293217489845685 no 2345 0.278782788375699 784 674664 SGTC_2397 5161689 200 µM -0.587807729993471 0.292853202393853 no 2346 0.278330677472195 800 2259942 SGTC_717 1532-0246 73.2 µM -0.588012953089956 0.292797697071755 no 2347 0.27826179926418 790 9561992 SGTC_3040 9091894 49.47 µM -0.5893020342031 0.292449159651444 no 2348 0.277829340262843 757 25236966 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.590008389342748 0.292258259552088 no 2349 0.277592512542001 823 229346 A bile salt which induces apoptosis. SGTC_612 0302-0167 22.4 µM -0.590290257650321 0.29218209778411 no 2350 0.277498034889972 806 235821 SGTC_2796 7949634 45.45 µM -0.592012459688675 0.291716953694965 no 2351 0.27692112249425 794 2971588 SGTC_2890 9046729 58.44 µM -0.592553938242286 0.291570778811208 no 2352 0.276739856555987 799 903329 SGTC_2588 indole-3-carbinol 100 µM -0.595385173076529 0.290807029328319 no 2353 0.275793017083899 807 3712 Induces cell cycle arrest. SGTC_1126 isoteolin 1.0172 µM -0.596745085020788 0.290440514433496 no 2354 0.275338793374869 788 133323 SGTC_731 3966-0296 387 µM -0.597569252051006 0.29021849541844 no 2355 0.27506369291968 771 660956 SGTC_1783 st039459 87.517 µM -0.597703987587352 0.290182207121334 no 2356 0.275018732139027 825 729761 SGTC_1289 0976-0073 69.1 µM -0.598879944655932 0.289865577108091 no 2357 0.274626473108815 805 3391136 SGTC_1760 st045453 10.4495 µM -0.600095501245716 0.289538455231144 no 2358 0.274221295297176 813 3323419 YIL048W NEO1 SGTC_2128 5255449 168.493 µM -0.600251422836958 0.289496507277369 no 2359 0.274169343794918 782 736008 SGTC_216 k038-0035 28.382 µM -0.600720175960145 0.289370414709586 no 2360 0.274013189263436 793 4444231 YPR107C YTH1 SGTC_3 0833-0587 95.581 µM -0.601058606385328 0.289279394428653 no 2361 0.273900476128036 798 5382644 SGTC_3326 9140064 16.379 µM -0.602678263371541 0.28884397686983 no 2362 0.273361372258859 805 1868434 SGTC_2257 7960413 200 µM -0.604773848357513 0.288281072274685 no 2363 0.27266463610186 793 2974689 YIL048W NEO1 SGTC_2076 5212012 200 µM -0.605695873560752 0.288033566893873 no 2364 0.272358362329013 798 604802 SGTC_418 lividomycin a 100 µM -0.606406035923347 0.287843001672469 no 2365 0.272122580671387 791 72394 An antibiotic. SGTC_2742 clothiapine 36.27 µM -0.606738615005854 0.287753777761177 no 2366 0.272012195683554 793 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2380 9035439 200 µM -0.606900703120093 0.287710297695704 no 2367 0.271958405740415 791 6462575 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.607088267240659 0.287659987577703 no 2368 0.271896168031005 796 88881 An O-methylated flavonoid and antioxidant. SGTC_2138 5575593 77.673 µM -0.608870769665066 0.287182076541558 no 2369 0.271305050214694 814 762213 SGTC_775 4577-0580 57.3 µM -0.609224085133064 0.28708739292789 no 2370 0.271187958980074 815 2006902 SGTC_884 0851-0618 334 µM -0.609696143285673 0.286960911005653 no 2371 0.271031554913603 815 9642473 SGTC_1619 st003326 88.7 µM -0.611133192313164 0.286576034751308 no 2372 0.27055570362671 773 2849032 SGTC_426 0988-0037 14.6 µM -0.611367581941903 0.286513282810537 no 2373 0.270478129592677 806 5383008 SGTC_319 1348-1596 45.5 µM -0.611753411129818 0.286410000928748 no 2374 0.27035045904551 809 5380505 SGTC_1275 0867-0008 21.1 µM -0.612936736647499 0.286093349020471 no 2375 0.269959085612992 795 3422836 SGTC_247 mechlorethamine 29.705 µM -0.613333743028891 0.285987149401459 no 2376 0.26982784315904 784 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1896 st058441 89 µM -0.614742765271808 0.28561038582134 no 2377 0.269362306323566 781 688759 SGTC_1673 st016611 27.3 µM -0.616115512181304 0.285243549353045 no 2378 0.268909142382667 824 5226799 SGTC_2592 piperlongumine 83.33 µM -0.616319887322885 0.285188953789635 no 2379 0.268841707895009 809 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1172 0370-0043 85 µM -0.616482662354275 0.285145474595842 no 2380 0.268788005625022 800 376585 SGTC_320 4092-0846 5.34 µM -0.617213905076178 0.284950189744342 no 2381 0.268546822621516 809 1359356 SGTC_226 1,3-diallylurea 8.28947 mM -0.617272035274379 0.284934668296926 no 2382 0.268527654428034 797 74537 YKL182W FAS1 SGTC_2552 juarezic acid 87.02 µM -0.617597468795368 0.284847781163763 no 2383 0.268420356769067 788 1549512 SGTC_1892 st058411 7.36 µM -0.617863743377299 0.284776698214048 no 2384 0.268332580256574 821 3934738 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.620638452010615 0.284036484009225 no 2385 0.267418766912661 816 16725076 SGTC_1700 st030840 7.9285 µM -0.622504510092987 0.283539190433403 no 2386 0.2668050895437 812 5499307 SGTC_571 k831-0106 44.2 µM -0.623766525808594 0.283203107285585 no 2387 0.266390463097473 832 4783639 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.626224101506231 0.282549187555085 no 2388 0.26558398043778 830 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3199 9111318 49.47 µM -0.626904694900823 0.282368221489129 no 2389 0.265360854793676 790 8548020 SGTC_534 k292-0788 63.4 µM -0.627095220111774 0.282317571866972 no 2390 0.265298410084046 824 4146317 SGTC_509 pifithrin 175 µM -0.627692806295736 0.282158736663767 no 2391 0.265102599389527 820 4817 A p53 inhibitor. SGTC_2607 solasodine 47.35 µM -0.628688427323502 0.281894201512495 no 2392 0.264776527979273 810 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2677 mitomycin C 100 µM -0.631365053998552 0.281183618481185 no 2393 0.263900930035633 825 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3307 9126885 69.2785 µM -0.632855524192792 0.280788308118548 no 2394 0.263413996995912 798 24824909 SGTC_3257 9139206 32.98 µM -0.634372464432492 0.280386253375596 no 2395 0.26291888764587 809 4910041 SGTC_1410 3909-8106 77.9 µM -0.634583180554995 0.280330426550694 no 2396 0.262850150328238 827 1039210 SGTC_3232 9132874 49.47 µM -0.634650768819243 0.28031252095396 no 2397 0.26282810443192 798 3784940 SGTC_797 k781-0471 270 µM -0.635952991407499 0.279967642141213 no 2398 0.262403531009847 798 23738129 SGTC_2013 4024628 200 µM -0.636420310390486 0.279843928215317 no 2399 0.262251253160931 833 5230760 SGTC_1725 st036284 20.55 µM -0.637323285476642 0.279604957661736 no 2400 0.261957143243566 797 707914 SGTC_770 0389-1121 67.2 µM -0.638053241618033 0.279411848661196 no 2401 0.261719511365617 810 6753108 SGTC_1583 clindamycin 39.6 µM -0.638673228627754 0.279247882753724 no 2402 0.261517766032861 809 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_798 1287-0182 476 µM -0.638918788714368 0.279182953223112 no 2403 0.26143788224201 828 1649755 SGTC_3075 9116269 49.47 µM -0.639853726077345 0.278935809855034 no 2404 0.261133850050853 824 17015205 YNL244C SUI1 SGTC_1113 artemisinin 1.17947 µM -0.640866427017791 0.278668230431199 no 2405 0.260804735072905 815 2240 An anti-malaria and mitochondrial poison. SGTC_1809 st050081 57.6 µM -0.641205571555566 0.278578648406146 no 2406 0.260694565112339 816 5036894 SGTC_348 k064-0012 10.7 µM -0.641213084367453 0.278576664122246 no 2407 0.260692124871887 810 5066323 SGTC_743 1275-0778 158 µM -0.64178037618106 0.278426850894712 no 2408 0.260507896476855 817 2849257 YMR203W TOM40 SGTC_569 4130-2812 160 µM -0.643582813839556 0.277951114936356 no 2409 0.259922998839239 823 743552 SGTC_308 4092-1169 104 µM -0.644064360053964 0.277824082661367 no 2410 0.259766850060551 821 2268590 YDL196W YDL196W SGTC_1024 4507-0395 26 µM -0.644309989143252 0.277759296430559 no 2411 0.259687219691698 791 4201836 SGTC_2814 7977482 42.97 µM -0.647323987406951 0.276964936481519 no 2412 0.258711139976885 816 6456762 SGTC_2073 5212005 126 µM -0.650340841690818 0.276170939231584 no 2413 0.257736040556162 832 691789 SGTC_444 curcumin 90.4 µM -0.65122229468903 0.275939163216293 no 2414 0.257451500282337 805 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2387 9077560 195.08 µM -0.651637467146948 0.275830027693317 no 2415 0.257317535759099 800 5303272 SGTC_2066 5222451 176 µM -0.651886977478754 0.275764449634483 no 2416 0.257237043196308 806 2281147 SGTC_828 2074-0507 139 µM -0.654243116244184 0.275145570766037 no 2417 0.256477593719482 813 X828 SGTC_2719 novobiocin 32.65 µM -0.6574028937436 0.27431667797373 no 2418 0.255460945724372 833 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_817 1391-0715 46 µM -0.659662305413089 0.273724731758866 no 2419 0.254735280714724 841 1353946 SGTC_3261 9137475 49.47 µM -0.660209015916842 0.273581593357173 no 2420 0.254559853655355 773 17027690 SGTC_465 cgp-37157 41 µM -0.660645694143853 0.273467289950985 no 2421 0.254419778946084 792 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2020 4017018 200 µM -0.662201141538469 0.273060333519946 no 2422 0.253921161361659 829 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_857 0438-0306 1.35 µM -0.662227199988919 0.273053518325777 no 2423 0.253912812378352 811 4686136 SGTC_2546 rhodinyl acetate 100 µM -0.663732453587937 0.272659985143148 no 2424 0.253430782087659 814 6708682 SGTC_412 gemfibrozil 100 µM -0.664830938007954 0.272372975380785 no 2425 0.253079316058306 808 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2701 st077767 14.721 µM -0.668117281308603 0.271515223422238 no 2426 0.252029365752615 811 5721188 SGTC_1548 st061468 90.8 µM -0.66871401866099 0.271359616455294 no 2427 0.251838961627269 819 390799 SGTC_2791 5663188 71.43 µM -0.671707179797652 0.270579782155013 no 2428 0.250885064834644 829 54690634 SGTC_2366 9070441 60.58 µM -0.671809116085205 0.270553243532282 no 2429 0.250852612254603 816 6837235 SGTC_2156 5649887 115 µM -0.672702568113457 0.270320693248485 no 2430 0.250568266730336 832 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2793 7325131 81.82 µM -0.673359306832613 0.270149819135717 no 2431 0.250359365326805 816 4176441 SGTC_2010 4012422 159 µM -0.675105523303167 0.269695741305721 no 2432 0.249804362375003 823 952393 SGTC_655 k060-0012 42 µM -0.676521210930018 0.269327893432468 no 2433 0.249354891878612 838 5994525 SGTC_1041 0206-0046 107 µM -0.676982430220931 0.269208106003025 no 2434 0.249208551017782 837 50494 SGTC_2779 methotrexate 400 µM -0.678227459547949 0.2688848816903 no 2435 0.248813742230188 832 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_979 1426-2828 121 µM -0.67993838581921 0.268441023150779 no 2436 0.248271737474857 823 747872 SGTC_552 k242-0005 476 µM -0.680860577191662 0.268201935746452 no 2437 0.247979857554837 854 4088318 SGTC_2805 7950783 58.44 µM -0.682838894668732 0.267689398753242 no 2438 0.247354324701576 827 1178958 YDL195W SEC31 SGTC_458 nppb 133 µM -0.683807838672074 0.267438547647685 no 2439 0.247048258061473 829 4549 A chloride channel blocker. SGTC_232 clozapine 119 µM -0.685479236776712 0.26700611616069 no 2440 0.246520779215749 822 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_892 0929-0076 29 µM -0.6856410064456 0.266964281148947 no 2441 0.246469758147386 824 5751038 SGTC_3149 9097855 49.47 µM -0.688362952360639 0.266260859672335 no 2442 0.245612123870944 806 25236625 YMR079W SEC14 SGTC_3240 9133527 49.47 µM -0.689227149550223 0.266037725058331 no 2443 0.245340167103409 843 17617455 SGTC_1701 st028638 40.4 µM -0.689379238708987 0.265998465634399 no 2444 0.245292322470855 830 3490878 SGTC_1428 4049-0204 61.7 µM -0.691712704781411 0.265396486245727 no 2445 0.244558883417106 843 X1428 SGTC_836 0330-0104 1.35 µM -0.692252163686247 0.26525741698674 no 2446 0.244389492658856 823 46494820 SGTC_35 0133-0054 64.071 µM -0.692420179781765 0.265214111005653 no 2447 0.244336748313988 833 99677 SGTC_978 1416-0512 87.4 µM -0.692593648468133 0.265169403391623 no 2448 0.244282298705767 853 6814003 SGTC_460 trequinsin 123 µM -0.692786758421393 0.265119638189339 no 2449 0.24422169164869 852 5537 A vasodilator. SGTC_1089 terbinafine 2.25 µM -0.693177962646048 0.265018837846876 no 2450 0.244098938069478 844 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2886 9058944 51.95 µM -0.693618613757796 0.264905320006349 no 2451 0.243960708713961 795 4949929 SGTC_790 1575-0012 79.1 µM -0.694208824589882 0.264753312233479 no 2452 0.243775629641952 839 378741 YLR208W SEC13 SGTC_1253 0550-0034 176 µM -0.694714143777623 0.264623203406158 no 2453 0.243617231243377 827 5969915 SGTC_3223 9129970 49.47 µM -0.696169624074764 0.264248630360581 no 2454 0.243161304137811 853 17248386 SGTC_2513 baicalein 25.65 µM -0.697722243205866 0.263849356135367 no 2455 0.242675457436955 845 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_972 1319-0219 195 µM -0.697979223206575 0.263783300393725 no 2456 0.24259509379125 846 23903702 SGTC_1615 st002656 86.5 µM -0.699719041105379 0.263336308681131 no 2457 0.242051391369478 830 1584458 SGTC_695 3505-6186 243 µM -0.700277035502988 0.263193031457316 no 2458 0.241877155185923 841 1819379 SGTC_2949 9072542 2.23 µM -0.703167512683909 0.262451476415168 no 2459 0.240975681279955 856 16457352 SGTC_1075 aripiprazole 15.2 µM -0.70331541748978 0.262413560065941 no 2460 0.240929602338212 832 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3152 9099253 49.47 µM -0.705782226454476 0.26178159145844 no 2461 0.240161788354513 834 25236131 SGTC_2101 5377231 179.231 µM -0.707798922486531 0.261265517374193 no 2462 0.239535067804508 851 2844213 SGTC_2968 9090663 33.37 µM -0.709328701845304 0.260874394571654 no 2463 0.239060260581992 854 25236811 SGTC_2980 9014342 25.29 µM -0.709768180772974 0.260762087526765 no 2464 0.238923951940483 836 2996599 SGTC_568 1193-0097 7.48 µM -0.711508513310557 0.260317597091894 no 2465 0.238384588590938 818 3646150 SGTC_1983 st071813 46.9 µM -0.712432586132847 0.26008174260789 no 2466 0.238098471453636 846 11838595 SGTC_1159 4092-0538 61.2 µM -0.71248352215121 0.26006874522621 no 2467 0.238082705803514 861 717301 SGTC_995 3931-2021 34.6 µM -0.717117805610915 0.25888761453234 no 2468 0.236650705001927 851 730143 SGTC_2078 5212016 200 µM -0.717372754739014 0.258822716782172 no 2469 0.236572063065686 837 1899708 SGTC_2180 6301957 200 µM -0.717533720520307 0.258781746994468 no 2470 0.23652241875994 842 845462 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.718807829020962 0.258457573211571 no 2471 0.236129666590424 858 7104 SGTC_3153 9100258 49.47 µM -0.722160292784721 0.257605605691994 no 2472 0.235097966383204 849 25236848 SGTC_3314 9135860 59.4275 µM -0.722915528316468 0.257413877829851 no 2473 0.234865891381524 835 25252478 SGTC_373 0844-0104 25.9 µM -0.727619166510506 0.25622145969736 no 2474 0.233423372281331 833 5375804 SGTC_457 grayanotoxin iii 135 µM -0.728097199962357 0.256100434973099 no 2475 0.23327704388177 852 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1362 1611-0397 101 µM -0.729454161871777 0.255757052607494 no 2476 0.232861948626768 846 27816 SGTC_791 1348-1292 225 µM -0.730020929189334 0.255613702015921 no 2477 0.232688695815832 860 5437054 SGTC_1727 st034309 9.9045 µM -0.730231407473102 0.255560477124216 no 2478 0.232624373808178 876 870305 SGTC_1672 st016598 6.51 µM -0.731607051099592 0.255212752579648 no 2479 0.23220422163499 857 4665860 YNL267W PIK1 SGTC_2789 5281112 71.43 µM -0.73204435130717 0.255102267062107 no 2480 0.232070748934298 844 765948 SGTC_328 k915-0120 63.5 µM -0.733363063674613 0.254769241031166 no 2481 0.231668510460141 833 6624543 SGTC_52 0329-0193 875 nM -0.736434182640197 0.253994547529581 no 2482 0.230733254214765 864 3739292 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.736704630717879 0.253926385936388 no 2483 0.230650995087735 829 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1945 st075991 56.6 µM -0.737024396171558 0.253845807168632 no 2484 0.230553756796265 858 1084980 SGTC_67 0335-0847 266 µM -0.737425118981125 0.253744846638578 no 2485 0.230431932326965 870 4552207 YOR254C SEC63 SGTC_2052 5265182 7.135 µM -0.737567592454208 0.253708956090804 no 2486 0.230388627380843 831 1239884 SGTC_478 N-arachidonylglycine 10 µM -0.740087503166859 0.253074605206154 no 2487 0.229623450501193 813 5283389 SGTC_1994 st072947 40.9 µM -0.740721930315459 0.252915028975719 no 2488 0.229431029757 854 5286565 YDL195W SEC31 SGTC_2848 9016370 25.97 µM -0.741235429503211 0.252785908309467 no 2489 0.22927535246753 826 7894410 SGTC_1422 4031-0024 15.5 µM -0.741269364955329 0.252777376377202 no 2490 0.229265066360407 876 782427 SGTC_2255 7941087 197.44 µM -0.74168912130083 0.252671855247667 no 2491 0.229137856248652 841 935561 SGTC_2622 2-methoxyxanthone 59.94 µM -0.742265127476833 0.252527092770266 no 2492 0.228963357980513 848 71034 A hepatoprotective. SGTC_827 3253-0474 693 µM -0.743398349972572 0.252242417708026 no 2493 0.22862027149283 847 5402065 SGTC_933 2914-0560 114 µM -0.744038375298476 0.252081712747991 no 2494 0.228426629568052 846 463887 SGTC_974 1326-0144 138 µM -0.744074748897061 0.252072581266566 no 2495 0.228415627375445 861 5411856 SGTC_1132 3456-3614 2.5 µM -0.747896156185691 0.251114201624513 no 2496 0.227261398126629 865 3125502 SGTC_1007 4101-0031 70 µM -0.748427332924284 0.25098113931863 no 2497 0.227101220515276 880 1146276 SGTC_1106 tegaserod maleate 11.7 µM -0.748617469227472 0.250933518337858 no 2498 0.227043899932278 853 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3020 9089140 49.47 µM -0.748707974985454 0.250910852211214 no 2499 0.227016617936108 858 17217859 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.749403763946461 0.250736636058858 no 2500 0.226806941511426 870 442882 SGTC_2994 9053520 71.4286 µM -0.751012425507124 0.250334094320223 no 2501 0.226322588932479 845 4647384 SGTC_2412 st077135 33.4 µM -0.751279664274826 0.250267255308072 no 2502 0.226242182530874 873 13258915 SGTC_1653 st012112 65 µM -0.751908287348144 0.250110067886491 no 2503 0.226053107006148 856 720429 SGTC_885 0865-0106 16.8 µM -0.751972804613645 0.250093938285295 no 2504 0.226033706734963 850 2793380 SGTC_3215 9129942 49.47 µM -0.754786366750256 0.24939107241039 no 2505 0.225188587648714 867 17682944 SGTC_1793 st048256 72.231 µM -0.756014497430955 0.249084598262492 no 2506 0.224820251836976 842 672022 SGTC_1664 st014217 9.02 µM -0.758317979449492 0.248510316067327 no 2507 0.224130323181531 867 3982782 SGTC_2845 9003024 42.97 µM -0.758613487749884 0.248436693845101 no 2508 0.224041900964983 842 2990173 SGTC_692 k241-0027 77.8 µM -0.758642158115482 0.248429551598295 no 2509 0.224033323251264 837 3600480 SGTC_2929 9013348 24.6 µM -0.760114256011568 0.248062975564765 no 2510 0.223593145951191 868 2995952 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.762762355539755 0.247404283346359 no 2511 0.222802567653712 855 2333 A French combination drug. SGTC_2640 pentamidine 10.38 µM -0.764435102712972 0.246988683973435 no 2512 0.222303998413742 846 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1084 voriconazole 435 nM -0.7644828995743 0.246976814182661 no 2513 0.222289761720551 870 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1228 0124-0032 52.5 µM -0.765248075387873 0.246786833294237 no 2514 0.222061918564817 850 X1228 SGTC_324 1315-0088 19.6 µM -0.766392275226759 0.246502892848041 no 2515 0.221721463886021 885 6787421 SGTC_2766 oltipraz 83.91 µM -0.766833131899285 0.246393538199822 no 2516 0.221590367377028 840 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_381 3461-2219 42.7 µM -0.771042014646156 0.245350833680961 no 2517 0.220341014272484 875 2883159 SGTC_2206 7254556 146.969 µM -0.772268878206953 0.245047338727251 no 2518 0.219977597024168 854 4398905 SGTC_2245 6637752 200 µM -0.774136992266582 0.244585602780797 no 2519 0.219424891863787 874 681890 SGTC_1519 esterone 74 µM -0.776737154734619 0.243943709517191 no 2520 0.218656930644029 862 698 A steroid. SGTC_1989 st071868 50.2 µM -0.780602926938674 0.242991062101909 no 2521 0.217518034883844 856 16414057 SGTC_1247 0448-0043 5.84 µM -0.782998452971744 0.242401740841782 no 2522 0.21681401025607 890 3089013 YGL099W LSG1 SGTC_2219 9098279 200 µM -0.784066972824012 0.242139125157383 no 2523 0.216500406788257 838 902349 SGTC_1351 1496-0003 46.5 µM -0.784886837112278 0.241937727478973 no 2524 0.216259960129159 869 3891978 SGTC_1999 st074831 12.5 µM -0.786698948678482 0.24149290922109 no 2525 0.215729059834475 880 17112523 SGTC_1501 4491-0275 38.4 µM -0.787482329837538 0.241300750581654 no 2526 0.215499784184677 865 5104718 SGTC_3123 9126162 49.47 µM -0.790056389989382 0.240669934703948 no 2527 0.21474741844038 849 25239884 SGTC_3234 9132280 49.47 µM -0.790097063922284 0.240659974095163 no 2528 0.21473554221817 857 17612295 SGTC_1926 methyl fluorone black 53.6 µM -0.790346172970174 0.240598974863973 no 2529 0.214662814170765 822 72721 Reacts with homocysteine. SGTC_3202 9113761 49.47 µM -0.790627166236932 0.240530178260544 no 2530 0.214580794624702 870 4798415 SGTC_1852 st056254 31.4 µM -0.791487731558445 0.240319549574609 no 2531 0.214329716276313 856 442583 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.791848753071253 0.240231217256088 no 2532 0.214224435619041 893 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_631 k072-0230 41.5 µM -0.794288299617703 0.239634789377696 no 2533 0.21351380697641 895 5773147 SGTC_502 l-744,832 89.3 µM -0.794491867389206 0.239585057060492 no 2534 0.213454570788185 887 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2642 cholecalciferol 100 µM -0.796115303918714 0.239188647549574 no 2535 0.212982509877326 854 9821465 A vitamin D precursor, similar to steriods. SGTC_2487 5918373 44.05 µM -0.797040105955714 0.23896299042337 no 2536 0.212713869624537 864 2876279 SGTC_1846 st056244 14.8 µM -0.800063557696137 0.238226063474963 no 2537 0.21183698692381 884 5393182 SGTC_2486 5283202 22.39 µM -0.801107501563684 0.237971905223856 no 2538 0.211534706888899 866 1377751 SGTC_78 0336-0123 156.75 µM -0.801967510422734 0.237762639455209 no 2539 0.211285876135675 860 6765896 SGTC_1906 st060206 94.7 µM -0.805112225862512 0.236998296593032 no 2540 0.21037746066044 874 5133468 SGTC_2088 5278280 127.392 µM -0.805156216372535 0.236987614009557 no 2541 0.210364769384303 883 791502 SGTC_1467 k284-1082 293 µM -0.807701171746528 0.236370051964229 no 2542 0.209631314456786 874 3334705 SGTC_297 0986-0032 24 µM -0.807888801734109 0.236324556530876 no 2543 0.209577299176851 864 2847425 SGTC_1101 ebselen 5.29 µM -0.808415970859249 0.236196757419606 no 2544 0.209425580538707 865 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_503 tyrphostin 8 294 µM -0.808923451974958 0.236073767146432 no 2545 0.2092795891539 912 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_852 0418-0143 439 µM -0.809361870110354 0.235967543003862 no 2546 0.209153513942709 863 5369229 SGTC_2551 apiole 73.87 µM -0.81490194202748 0.234627513347097 no 2547 0.207564220729993 856 10659 A possible DNA adduct former. SGTC_2312 7706453 155.7 µM -0.81571932153497 0.234430162905272 no 2548 0.207330342815851 881 976098 SGTC_132 0417-1715 25.805 µM -0.816434999872815 0.234257442927914 no 2549 0.207125692793786 880 6769098 SGTC_2664 lyso-paf C-16 73.48 µM -0.817364537920723 0.234033215796967 no 2550 0.206860067517805 878 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2075 5212009 200 µM -0.818632228553733 0.233727609763729 no 2551 0.206498136768919 868 780898 SGTC_29 0299-0004 12.984 µM -0.818762175477227 0.233696295568894 no 2552 0.206461057612189 867 16871 A napthoquinone isolated from Swertia calycina. SGTC_996 3970-0799 1.8 µM -0.821513593382885 0.233033813901347 no 2553 0.205676892226973 875 6615648 YGL040C HEM2 SGTC_1521 st012942 49.4 µM -0.822250011808111 0.232856677421875 no 2554 0.205467310224967 854 24207259 SGTC_1140 3229-1848 2.98 µM -0.82305673349836 0.232662716237271 no 2555 0.205237865784329 880 2849525 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.823970197734769 0.232443199254076 no 2556 0.204978245928913 867 6312947 SGTC_1434 4073-0095 163 µM -0.824086212723465 0.232415327634426 no 2557 0.20494528675568 864 24133745 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.824164297978405 0.232396569359094 no 2558 0.204923104969932 874 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1187 1391-0724 117 µM -0.827256480584623 0.231654417419649 no 2559 0.204045852366533 884 6997986 SGTC_2688 kanamycin b 96.69 µM -0.827375859388247 0.231625791925829 no 2560 0.204012029499771 862 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_821 1114-0266 29.2 µM -0.828461096942136 0.231365656429331 no 2561 0.203704709013036 870 3123235 SGTC_1469 k284-2957 126 µM -0.8292300634743 0.231181430949544 no 2562 0.203487118175217 857 23884841 SGTC_103 0844-0104 51.839 µM -0.829852440027691 0.23103238477547 no 2563 0.203311108772445 889 5375804 SGTC_1260 0700-1617 7.75 µM -0.831509958151231 0.230635705587425 no 2564 0.20284280252335 856 2853078 SGTC_930 2810-3379 265 µM -0.833342249949766 0.230197642564265 no 2565 0.202325867272921 904 1015764 SGTC_284 0988-0104 32.6 µM -0.833389019765253 0.230186466964851 no 2566 0.202312682661439 896 4666532 SGTC_2118 5526350 200 µM -0.833993007118313 0.230042172076366 no 2567 0.202142462210315 889 743594 SGTC_2248 tofa 1.1 µM -0.834250462533804 0.229980680382556 no 2568 0.20206993016322 868 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_11 0438-0307 1.3 µM -0.834747954562261 0.229861883439504 no 2569 0.201929817542576 901 4011476 SGTC_1139 k015-0024 46.9 µM -0.835146867138052 0.229766651269783 no 2570 0.201817510658579 897 2766652 SGTC_2921 7974240 10.71 µM -0.837877584148467 0.229115342370766 no 2571 0.201049729673687 868 2979074 YDR527W RBA50 SGTC_2102 5377816 72.7585 µM -0.838621835658571 0.228938009169318 no 2572 0.200840776704092 873 1379702 SGTC_3227 9130768 49.47 µM -0.842660635635514 0.227977026376587 no 2573 0.199709134295576 905 17720899 SGTC_1245 0418-0076 17.2 µM -0.844411811698697 0.227561061825187 no 2574 0.19921966211554 890 6790114 SGTC_257 daunorubicin 18.5 µM -0.845056219097457 0.227408100540037 no 2575 0.199039725470611 862 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2055 5235184 200 µM -0.845773624013591 0.227237880179799 no 2576 0.198839521102842 874 2836034 SGTC_2363 9053361 176 µM -0.848850286472594 0.226508688072309 no 2577 0.19798230225416 884 6469797 YMR079W SEC14 SGTC_386 1509-0011 3.07 µM -0.852405724322513 0.225667670516258 no 2578 0.196994472056166 879 3107280 SGTC_357 1325-0123 420 µM -0.854070382412286 0.225274513655072 no 2579 0.1965329965965 919 1098503 SGTC_1497 4476-2978 41.3 µM -0.854397858624318 0.225197216421415 no 2580 0.196442291012877 870 1528379 SGTC_2435 5706476 10.6 µM -0.854910208392325 0.225076311920814 no 2581 0.196300429369842 859 5725375 SGTC_1350 1495-0454 146 µM -0.857303460803495 0.224512038684793 no 2582 0.195638598189883 874 1069057 SGTC_1903 st060211 78.3 µM -0.857535660585522 0.224457334129136 no 2583 0.195574457724806 865 688960 SGTC_1483 3453-0561 55.9 µM -0.857818908689894 0.224390613208015 no 2584 0.195496233489723 913 4546991 SGTC_234 nsc-17383 10.7 µM -0.860335899127984 0.223798214536917 no 2585 0.194801954695318 861 408974 SGTC_154 3389-1638 511.116 µM -0.860823878356534 0.223683466753314 no 2586 0.19466752579565 924 5238686 SGTC_2276 7947513 42.08 µM -0.861284114583458 0.223575273366408 no 2587 0.194540791293175 894 2105100 SGTC_1006 4099-6547 255 µM -0.862952088497091 0.223183411727531 no 2588 0.194081904945882 912 3146833 SGTC_3246 9135460 32.98 µM -0.865399482132921 0.222609147253757 no 2589 0.193409782574101 890 41446951 SGTC_318 1488-0629 67.2 µM -0.866569834915205 0.222334829842214 no 2590 0.193088873686437 913 3662576 SGTC_179 1273-0063 6.77 µM -0.867879226291692 0.222028152054664 no 2591 0.19273022620293 910 3108139 SGTC_2874 9043904 71.43 µM -0.869012775675839 0.221762854065777 no 2592 0.192420071485282 905 4463428 SGTC_3195 9113082 49.47 µM -0.869133460679927 0.221734619395403 no 2593 0.192387068391651 878 17018038 SGTC_564 3555-0129 330 µM -0.869699865700077 0.221602134441097 no 2594 0.192232222836464 871 563260 SGTC_2281 7943571 200 µM -0.870761693609001 0.221353889546515 no 2595 0.191942142532517 894 1244024 SGTC_2378 9074213 121.43 µM -0.871092374903737 0.221276612007122 no 2596 0.191851858594418 888 657714 SGTC_2819 7996655 46.38 µM -0.872024261944883 0.221058920589624 no 2597 0.191597570942592 863 6456960 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.87293354505481 0.22084662769851 no 2598 0.191349650415931 899 803109 SGTC_587 k089-0003 57 µM -0.873791899960347 0.220646332308917 no 2599 0.191115796204351 866 9659696 SGTC_1358 1509-0022 2.48 µM -0.874070404065138 0.220581366302896 no 2600 0.191039956918986 901 3258434 SGTC_2539 epi(13)torulosol 80 µM -0.874868477743676 0.220395262218543 no 2601 0.190822736198608 881 6708597 SGTC_2379 9035213 200 µM -0.875905263135671 0.220153627025073 no 2602 0.190540769039851 872 646551 SGTC_2747 doxorubicin 7.63 µM -0.876401632559626 0.220037996020228 no 2603 0.190405865569509 820 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3333 9141820 12.094 µM -0.877272990628915 0.219835094380631 no 2604 0.19016918945105 885 1939433 SGTC_3133 9127736 49.47 µM -0.877611732858435 0.219756244952129 no 2605 0.190077229943039 877 27243420 SGTC_2237 6667747 47.222 µM -0.878525858225889 0.219543543955494 no 2606 0.189829205629572 917 729940 YDL015C TSC13 SGTC_2389 9091542 195.52 µM -0.884075941659046 0.218254677657485 no 2607 0.188327609689262 882 3626624 YOL127W RPL25 SGTC_1688 st021091 57.6 µM -0.88693988626238 0.217591307986036 no 2608 0.187555632929484 921 3656366 SGTC_1655 st012546 55.1 µM -0.887382034776169 0.217488997811966 no 2609 0.187436626203807 907 720985 YLR208W SEC13 SGTC_2649 anisomycin 9.56 µM -0.887627844922476 0.217432131019902 no 2610 0.187370485229917 898 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2472 5377652 49.4 µM -0.888129748254028 0.217316045174527 no 2611 0.187235481201195 928 1610903 SGTC_1149 3909-7961 23.3 µM -0.888948643156805 0.217126718812599 no 2612 0.187015340638968 898 735261 SGTC_1138 3761-0006 1.03 µM -0.891482832490541 0.216541424983415 no 2613 0.186335098748114 903 12061087 SGTC_2208 7283366 200 µM -0.891917372272849 0.216441155871177 no 2614 0.186218611194866 874 898663 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.892694067295136 0.216262002128478 no 2615 0.186010514161081 923 91467 include heat shock SGTC_1640 st009078 66.4 µM -0.897733761149326 0.215101625820464 no 2616 0.184663752935919 892 690618 SGTC_667 1498-1044 59 µM -0.899528529117851 0.214689259665721 no 2617 0.184185603409389 920 6739982 SGTC_709 3807-1509 243 µM -0.902511353181178 0.214004942757517 no 2618 0.183392646617807 931 1886677 YPL242C IQG1 SGTC_3100 9120536 49.47 µM -0.902512685758514 0.214004637322793 no 2619 0.183392292840483 883 16421196 SGTC_2957 9076800 11.52 µM -0.902702688099766 0.213961090243214 no 2620 0.183341854705133 936 16459615 SGTC_1697 st025554 27.742 µM -0.9031995106314 0.213847246711301 no 2621 0.183210008780383 893 1269519 SGTC_288 1315-0019 35.1 µM -0.903655461557734 0.213742799677553 no 2622 0.183089061344149 902 6811474 SGTC_272 doxorubicin 8.13 µM -0.904633021124649 0.213518965228321 no 2623 0.182829917761054 913 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_812 4251-0442 148 µM -0.906187816016728 0.213163241196697 no 2624 0.182418225410142 926 5723007 SGTC_2960 9079389 5.97 µM -0.90796888700956 0.212756172169259 no 2625 0.181947329995769 911 16457355 SGTC_669 0108-0021 26.2 µM -0.909590167028595 0.212386018729762 no 2626 0.181519343096983 907 17201 SGTC_2211 7117706 200 µM -0.909977057717732 0.212297743600371 no 2627 0.18141730456044 895 822771 SGTC_2854 9024559 71.43 µM -0.913312150438601 0.211537679912314 no 2628 0.18053919689951 919 3163529 SGTC_2324 6149169 200 µM -0.913328633659271 0.211533927366719 no 2629 0.18053486360837 912 2888231 SGTC_596 1155-0152 116 µM -0.914236886225912 0.211327216181512 no 2630 0.180296192976543 901 280313 SGTC_1621 st003705 32.4 µM -0.916025360028925 0.210920519604076 no 2631 0.179826796925782 903 24207032 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.916156850734517 0.210890636912852 no 2632 0.179792316693613 877 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_128 0906-2981 13.371 µM -0.917753001825889 0.210528092257097 no 2633 0.179374096227745 901 6740226 SGTC_690 glyoxal 20.3 µM -0.918132329057322 0.21044198690581 no 2634 0.179274795655148 907 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1815 st051655 58.2 µM -0.919254457963188 0.21018739041237 no 2635 0.178981246339322 915 5984156 SGTC_2492 derrusnin 100 µM -0.919375066984456 0.210160036561439 no 2636 0.178949712988715 920 1715307 Part of coumarin class of compounds. SGTC_960 1222-0186 7.7 µM -0.919689973180985 0.210088626412145 no 2637 0.178867396927422 918 3126296 SGTC_2148 5546263 113.568 µM -0.920591768645125 0.209884208365326 no 2638 0.178631800665222 925 792097 SGTC_3328 9140624 29.0385 µM -0.921373118817301 0.209707187295124 no 2639 0.178427829110737 908 4904392 SGTC_2997 9067075 71.4286 µM -0.923030620348143 0.209331957975061 no 2640 0.177995624137332 905 27209819 SGTC_522 1273-0010 11.6 µM -0.923323064545036 0.209265794762389 no 2641 0.17791943586125 874 5705015 SGTC_363 0455-0021 3.06 µM -0.923462619141151 0.209234225965293 no 2642 0.177883086007114 894 4597466 SGTC_3037 9091026 49.47 µM -0.923561410926972 0.209211879862676 no 2643 0.177857356493887 907 25236398 YIL048W NEO1 SGTC_988 1497-1057 103 µM -0.928092885827969 0.208188398725034 no 2644 0.176679694794319 902 3533044 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.928342266135615 0.208132159471971 no 2645 0.176615028080247 905 140250 A respiratory chain inhibitor. SGTC_1923 st058458 19.1 µM -0.929839836650365 0.207794621971777 no 2646 0.176227008508764 937 3534982 SGTC_2045 5106652 78.05 µM -0.931686232990082 0.207378907956423 no 2647 0.175749351639381 892 673349 SGTC_1921 5740136 50 µM -0.932783906650075 0.207132001204613 no 2648 0.17546577605129 904 1774243 SGTC_1 0258-0098 57.368 µM -0.932889819209391 0.207108186818046 no 2649 0.175438429703009 871 6790032 YDR047W HEM12 SGTC_2834 9001755 58.44 µM -0.934865386844981 0.206664278363012 no 2650 0.174928838519272 923 2989575 SGTC_1239 0337-0584 35.4 µM -0.936181225649942 0.206368923312271 no 2651 0.174589943919036 927 914301 YML130C ERO1 SGTC_1552 6-methylflavone 10.6 µM -0.937566695961153 0.206058209171974 no 2652 0.174233566625248 907 689013 SGTC_1889 st059080 5.18 µM -0.939666310322613 0.205587865801406 no 2653 0.173694375584088 909 176925 Isolated from Daphnopsis sellowiana. SGTC_2738 aclarubicin 5.55 µM -0.940792696904748 0.205335802133042 no 2654 0.173405552084319 895 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1306 1185-0270 9.02 µM -0.941408492059908 0.205198076659042 no 2655 0.173247781706908 922 1548076 SGTC_1291 0993-0025 5.79 µM -0.942195735136867 0.20502208601524 no 2656 0.173046218519118 923 4353356 SGTC_2300 7976697 71.57 µM -0.943542555595121 0.204721208237933 no 2657 0.172701729497211 895 2236109 SGTC_2229 7354935 190 µM -0.944134619295226 0.204589025199367 no 2658 0.172550430187825 919 318112 SGTC_637 1181-0519 7.26 µM -0.944928138840364 0.204411945167457 no 2659 0.172347782311771 918 6252091 YGR060W ERG25 SGTC_584 0986-0246 15.4 µM -0.944966812672324 0.204403317134578 no 2660 0.172337909726065 941 53315 YDR232W HEM1 SGTC_2464 5717415 7.67 µM -0.945119006319673 0.204369365226818 no 2661 0.172299061511368 904 5285744 SGTC_2746 daunorubicin 9.88 µM -0.954555103113083 0.202270890044532 no 2662 0.169901365435171 873 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3139 9095020 49.47 µM -0.95527117771194 0.202112171504383 no 2663 0.169720289538513 852 25236292 SGTC_1177 0983-0204 23.6 µM -0.958505263010883 0.20139626264033 no 2664 0.168904019432582 895 766818 SGTC_3010 9080089 71.4286 µM -0.960243832548137 0.201012035510663 no 2665 0.168466255567415 913 17027233 SGTC_2587 piperic acid 92.2 µM -0.960540999949788 0.200946404988855 no 2666 0.16839150324418 908 5370536 SGTC_2277 7947813 106.88 µM -0.960732250436202 0.200904173410505 no 2667 0.168343405555677 935 1246798 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.961646377904356 0.200702391046029 no 2668 0.168113633205043 930 4174840 SGTC_1684 st024538 14.6195 µM -0.963725955371211 0.200243803386826 no 2669 0.167591668935178 932 6732859 SGTC_471 1-acyl-paf 4 µM -0.964798716960403 0.200007484779943 no 2670 0.167322819349 909 16759367 SGTC_3318 9139014 38.6185 µM -0.965353866633775 0.19988525674761 no 2671 0.167183800003382 923 16643984 SGTC_843 0310-0051 143 µM -0.965822876370642 0.199782029273396 no 2672 0.167066409672478 919 2065037 SGTC_687 k029-0044 34.9 µM -0.970285169490266 0.198801498361309 no 2673 0.165952183770754 913 5829338 SGTC_2227 7312221 64.1025 µM -0.971344603228035 0.198569128444935 no 2674 0.165688352301033 935 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_619 1652-1634 108 µM -0.971874856815903 0.198452887309405 no 2675 0.1655564048042 943 5400454 SGTC_331 k048-0133 24.5 µM -0.978631142380578 0.196975384758741 no 2676 0.163881132982761 918 6813582 SGTC_1991 st073000 8.92 µM -0.979328427781053 0.196823278453903 no 2677 0.16370886426798 931 4301969 YIL048W NEO1 SGTC_3165 9101544 49.47 µM -0.979552054459185 0.196774511447217 no 2678 0.163653640804844 930 5002184 SGTC_699 0375-0592 111 µM -0.979947579917959 0.19668827582536 no 2679 0.163555997433754 872 762578 SGTC_1692 fluoroquinolonic acid 71 µM -0.985322013736262 0.19551876893105 no 2680 0.162232961446879 922 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3101 9120531 49.47 µM -0.988338499854804 0.194864218904359 no 2681 0.161493448067067 949 24824904 SGTC_211 3455-0679 143.504 µM -0.988657392185002 0.194795100145882 no 2682 0.161415397969659 909 748649 SGTC_1001 4048-4355 44.4 µM -0.990186287439887 0.194463924817745 no 2683 0.161041536856168 918 21824233 SGTC_1166 k206-0078 225 µM -0.99054353324168 0.194386590919438 no 2684 0.160954260970219 921 5404595 SGTC_715 0868-0130 184 µM -0.991400078235238 0.194201248744471 no 2685 0.16074513103579 967 2876258 SGTC_2080 5212524 12.4 µM -0.994906466927283 0.193443646986748 no 2686 0.159890878659654 913 260183 SGTC_1511 0906-3109 28.5 µM -0.994979955237612 0.193427788178012 no 2687 0.159873006720808 931 2882180 SGTC_2408 sulbentine 18.36 µM -0.998787214180971 0.192607265441932 no 2688 0.158948890545983 906 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3080 9117754 49.47 µM -1.00003384380903 0.19233906062262 no 2689 0.158647064859043 926 9550191 SGTC_3095 9117207 49.47 µM -1.00027130796421 0.192287997555664 no 2690 0.15858961425228 924 17015229 SGTC_1004 4084-0029 199 µM -1.00242859231416 0.1918244861593 no 2691 0.158068319267938 927 716894 YLR208W SEC13 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.00329966345719 0.191637522941017 no 2692 0.15785814923354 913 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2499 avocadenofuran 51.48 µM -1.00423338757222 0.191437236127716 no 2693 0.157633066314645 943 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2162 5663267 200 µM -1.00603160982895 0.19105187323722 no 2694 0.15720018239032 948 6456493 SGTC_657 3534-0529 86.7 µM -1.00811922347647 0.190605090361574 no 2695 0.156698615028466 959 1049549 SGTC_1860 st056228 74.6 µM -1.00817593624731 0.190592961872466 no 2696 0.156685004003603 941 688679 SGTC_3150 9097574 49.47 µM -1.00912016938321 0.190391099520804 no 2697 0.156458503057522 921 17217476 SGTC_2063 5246145 200 µM -1.01096556859313 0.189996961139894 no 2698 0.156016454790257 940 711240 SGTC_59 0330-0160 1.33 µM -1.01521204043881 0.189091910943291 no 2699 0.155002381168431 937 4293482 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.01555724628445 0.189018454130103 no 2700 0.154920136433625 948 390807 SGTC_392 N-ethylmaleimide 8.33 µM -1.01875105450261 0.188339673300427 no 2701 0.154160583905396 918 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1547 harmine 94.2 µM -1.02027728114753 0.188015835633327 no 2702 0.153798487451173 920 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_393 acivicin 6.25 µM -1.02073300964969 0.187919204976209 no 2703 0.153690475343009 911 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1026 k007-1105 30.6 µM -1.02201740570449 0.187647032349454 no 2704 0.153386331212393 922 7066794 SGTC_718 1130-0073 349 µM -1.02214442470657 0.187620129362231 no 2705 0.153356274877031 944 6740020 SGTC_2959 9079155 11 µM -1.02267599276732 0.187507567586351 no 2706 0.153230532977011 925 16189457 SGTC_1346 1488-2224 62.4 µM -1.02310411978402 0.187416940235807 no 2707 0.153129309637982 910 3722427 SGTC_1384 3089-0840 101 µM -1.02725547223807 0.186539572820703 no 2708 0.152150091779899 926 1069836 SGTC_1808 st050063 61.5 µM -1.02820855063337 0.186338504085647 no 2709 0.151925868556848 935 4011993 SGTC_2884 9058502 51.95 µM -1.0286842911141 0.186238188480613 no 2710 0.151814027028484 931 6471554 SGTC_5 0352-0601 109.883 µM -1.028835409371 0.186206330382497 no 2711 0.15177851218481 929 762456 SGTC_2525 harmine 47.85 µM -1.03039310275326 0.185878141045326 no 2712 0.151412754840569 913 5280953 A monoamine oxidase inhibitor SGTC_2246 7293507 91.5585 µM -1.03404586800492 0.185109950465467 no 2713 0.150557360368711 935 887656 SGTC_165 k038-0023 64.381 µM -1.03479931810416 0.184951742695188 no 2714 0.150381320726673 957 46368543 SGTC_259 usnic acid 108.925 µM -1.03549767530393 0.184805178262306 no 2715 0.150218275768055 969 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_79 0052-0007 94.094 µM -1.03670621015761 0.184551713315537 no 2716 0.149936398461372 902 2801472 SGTC_2 0422-0095 29 µM -1.03898646689606 0.184074066214701 no 2717 0.149405515124518 920 6790840 SGTC_2765 myclobutanil 7.74 µM -1.04135791194651 0.183578135011648 no 2718 0.148854734181 950 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1237 0330-0133 46.1 µM -1.04215907145823 0.183410779944623 no 2719 0.148668967560104 952 X1237 YHR072W ERG7 SGTC_2744 captopril 92.04 µM -1.04240090886049 0.183360280965478 no 2720 0.14861292265272 926 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2340 7987427 183.45 µM -1.04368658706608 0.183091959227087 no 2721 0.148315208744062 927 2239331 SGTC_846 0335-0850 148 µM -1.04411083189418 0.183003472878656 no 2722 0.148217057467881 917 6819598 SGTC_1891 st059073 26.2 µM -1.04463375876167 0.182894440765988 no 2723 0.148096135391199 937 688754 SGTC_2720 fluspirilene 36.88 µM -1.04773882388241 0.182247859022619 no 2724 0.147379477495588 949 3396 An atypical antipsychotic. SGTC_1370 2001-0092 44.6 µM -1.04972373869171 0.181835280674955 no 2725 0.146922573127873 931 790957 SGTC_604 1000-0114 314 µM -1.05077609318355 0.181616778643566 no 2726 0.146680719104596 954 1572745 SGTC_757 1066-0008 322 µM -1.0514735994111 0.181472044902474 no 2727 0.14652056424979 921 6842497 SGTC_1558 st069300 45.6 µM -1.05304997362991 0.181145210610399 no 2728 0.146159044477609 922 24208000 SGTC_2619 obliquin 87.91 µM -1.05313772591573 0.181127027512289 no 2729 0.146138937316014 924 6708593 A bioactive alkalod. YER133W GLC7 SGTC_936 3005-4620 401 µM -1.05547266600541 0.180643626012201 no 2730 0.145604602156684 943 777207 SGTC_111 0083-0039 52.457 µM -1.06003924108706 0.179700551106591 no 2731 0.144563373693904 905 759313 SGTC_794 k038-0031 316 µM -1.06213257234927 0.17926927877594 no 2732 0.144087752455201 929 6624242 SGTC_2431 5490079 200 µM -1.06327785289793 0.179033601477719 no 2733 0.143827982826175 968 5722345 SGTC_550 4123-0385 25.7 µM -1.06619791969518 0.178433589051907 no 2734 0.143167091180346 961 5731123 SGTC_2709 st078560 56 µM -1.06627718103401 0.178417320190098 no 2735 0.14314918079576 950 17250903 SGTC_377 3970-0964 33.1 µM -1.066786832854 0.178312733442995 no 2736 0.143034052860098 940 16481235 SGTC_1424 4048-1941 275 µM -1.06684685806794 0.178300418083071 no 2737 0.143020497567317 935 X1424 SGTC_2057 5236571 38.335 µM -1.06962568399578 0.177730873827197 no 2738 0.142393914762441 946 54684039 YBR257W POP4 SGTC_2175 5807670 165.306 µM -1.07143808037713 0.177360026750846 no 2739 0.141986249073946 892 241186 SGTC_1659 st012954 42.1 µM -1.07458747704519 0.176716769793031 no 2740 0.141279730496207 955 24207262 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.07493189208514 0.176646513402154 no 2741 0.141202611107836 956 521171 SGTC_340 k038-0059 454 µM -1.07507437049396 0.176617454741325 no 2742 0.141170716528393 935 23733424 SGTC_161 4065-0411 162.148 µM -1.07765310774587 0.176092040392917 no 2743 0.14059429617073 950 1906281 YLR208W SEC13 SGTC_1176 0848-0131 83.3 µM -1.07839968637011 0.17594011086435 no 2744 0.140427713459628 961 6769040 SGTC_2752 diclazuril 33.15 µM -1.07956386159879 0.175703365684726 no 2745 0.140168220700554 922 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3009 9080819 71.4286 µM -1.08026285637982 0.175561316021286 no 2746 0.140012572503329 958 17027216 SGTC_781 4335-2806 94.4 µM -1.0863320682934 0.174330992207166 no 2747 0.138666052080087 990 845254 SGTC_595 3909-8003 73.7 µM -1.08947660518512 0.173695705288907 no 2748 0.137971883025381 964 699517 SGTC_3045 9092950 49.47 µM -1.0918555983088 0.173216060133391 no 2749 0.137448288353201 951 44120432 SGTC_2186 6124449 200 µM -1.0934162236686 0.172901870316017 no 2750 0.137105546770141 946 3834182 YLR033W RSC58 SGTC_1555 citronellol 128 µM -1.09415108067159 0.172754052519376 no 2751 0.13694436124061 958 8842 A terpine precursor. SGTC_3090 9117696 49.47 µM -1.09418187106246 0.172747860736113 no 2752 0.13693761042057 920 7923821 SGTC_2568 diosmetin 100 µM -1.09455113240614 0.172673615272045 no 2753 0.136856667267878 961 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2760 etidronate 98.04 µM -1.09682007047489 0.172217858284772 no 2754 0.136360027360477 950 3305 A chelator and antioxidant. SGTC_141 0443-0274 32.331 µM -1.09687706339976 0.172206420123205 no 2755 0.136347568273774 861 1627241 SGTC_807 1315-0151 48 µM -1.09690132036253 0.17220155203339 no 2756 0.13634226575357 963 4011080 SGTC_697 0508-1955 564 µM -1.09839122236809 0.171902714415937 no 2757 0.136016846798099 939 6243113 SGTC_3107 9121808 49.47 µM -1.10006320892569 0.171567749691922 no 2758 0.135652291223031 889 662681 SGTC_1678 st019265 80.2 µM -1.1002954323745 0.171521259200636 no 2759 0.135601710818045 941 5367020 SGTC_2522 biochanin a 4.94 µM -1.10098234735313 0.171383787854483 no 2760 0.135452170055457 947 5280373 A possible chelator. SGTC_740 k014-0057 261 µM -1.10227753694956 0.171124774995476 no 2761 0.135170515993586 958 4012779 SGTC_1757 st041620 31.8375 µM -1.10261910713173 0.171056509306168 no 2762 0.135096304540997 985 5289815 SGTC_1811 st050069 61.5 µM -1.10370102890525 0.170840393078418 no 2763 0.134861424582603 930 3877702 SGTC_1355 1499-0035 1.68 µM -1.10459021673612 0.170662906742357 no 2764 0.134668596082698 975 1548538 SGTC_839 0122-0028 230 µM -1.10488261600918 0.170604568184299 no 2765 0.134605227991933 956 759448 SGTC_1379 2144-0755 36.5 µM -1.10614479259854 0.170352889315285 no 2766 0.134331926878262 958 5392327 SGTC_632 0781-2353 4.65 µM -1.10626576610403 0.170328779611792 no 2767 0.134305752317766 974 6811515 YHR007C ERG11 SGTC_1752 st044819 83.042 µM -1.10704192927577 0.170174144323844 no 2768 0.134137900278268 948 441209 YML126C ERG13 SGTC_1058 3448-5425 97.3 µM -1.11033693180954 0.169518681641233 no 2769 0.133426932109107 952 7279705 SGTC_778 3456-2434 196 µM -1.11153398972259 0.169280957016363 no 2770 0.133169283991689 871 5539063 SGTC_1224 0823-0416 294 µM -1.11209072487064 0.169170467513731 no 2771 0.133049572125483 951 3598164 SGTC_866 0495-0101 262 µM -1.11234614132923 0.169119793132611 no 2772 0.132994676046225 935 635694 SGTC_1320 1313-0481 95.3 µM -1.11245829415293 0.169097545199668 no 2773 0.13297057622172 946 6813365 YLR208W SEC13 SGTC_644 1498-1197 63.3 µM -1.1130948109496 0.168971313961735 no 2774 0.132833856028834 960 6741615 SGTC_2003 4023581 200 µM -1.11441095974964 0.168710493095235 no 2775 0.132551461843629 951 16641307 SGTC_249 wiskostatin 11.211 µM -1.11522838890824 0.168548633693432 no 2776 0.132376281800439 921 2775510 A n-wasp and actin depolymerizer. SGTC_2861 9024595 19.48 µM -1.12075384978428 0.167457154780545 no 2777 0.131196326716097 949 16482810 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.12111632397523 0.167385712507924 no 2778 0.13111917552572 966 23847180 SGTC_720 r052-1644 49.9 µM -1.12610877735702 0.166403717801352 no 2779 0.130059739615803 964 1422863 YOR257W CDC31 SGTC_1295 1013-0063 9.78 µM -1.12630889614665 0.166364432967392 no 2780 0.130017396771817 970 6826038 SGTC_361 000s-0510 1.45 µM -1.12694171584025 0.166240245083933 no 2781 0.129883562170561 942 660 SGTC_1270 0831-1170 17.3 µM -1.12986048109061 0.165668226358003 no 2782 0.129267509175572 948 6764716 SGTC_2831 7999036 19.48 µM -1.12992784335692 0.16565503976488 no 2783 0.129253315221958 979 2988270 SGTC_2375 9072683 200 µM -1.13175364855899 0.165297885275775 no 2784 0.128869009846748 974 16798029 SGTC_2450 5739737 12.93 µM -1.13238255475168 0.165174977392986 no 2785 0.128736817969001 947 2262825 SGTC_23 0213-0011 39.996 µM -1.13307550585916 0.165039621649756 no 2786 0.128591273249613 973 627608 SGTC_1396 3511-0007 98.6 µM -1.13424256352271 0.164811819947226 no 2787 0.12834640724956 951 X1396 SGTC_875 0709-0210 25.7 µM -1.13692761507051 0.164288489896056 no 2788 0.127784273386823 971 6251364 SGTC_1980 st071811 45.7 µM -1.13719474730775 0.164236483475282 no 2789 0.127728441161964 958 4974850 SGTC_2795 7780010 54.55 µM -1.13833492252693 0.164014629438956 no 2790 0.127490328411348 949 953673 SGTC_1170 0310-0127 64.8 µM -1.13883315292687 0.163917745388343 no 2791 0.127386375576531 969 774975 SGTC_1658 st012944 20 µM -1.13976111298666 0.16373739670444 no 2792 0.127192919364635 958 24207260 SGTC_80 0159-0065 512.242 µM -1.1399420137218 0.163702253723467 no 2793 0.127155229955503 942 1548079 SGTC_3125 9127534 49.47 µM -1.14129880864102 0.163438829809963 no 2794 0.126872798877531 946 1639235 SGTC_307 1501-1223 22.3 µM -1.1431370066314 0.163082380150182 no 2795 0.126490855774299 969 2830329 SGTC_2840 9008771 71.43 µM -1.14572362290968 0.162581659203651 no 2796 0.12595476311137 935 2992978 SGTC_193 1273-0060 1.558 µM -1.14605439131176 0.162517700783796 no 2797 0.125886323682859 964 2847393 YHR072W ERG7 SGTC_1938 st074717 56.4 µM -1.14710246665218 0.162315149778114 no 2798 0.125669637274341 909 17250979 SGTC_1540 guanosine 70.6 µM -1.14722316159453 0.162291834833874 no 2799 0.125644700678662 938 6802 Guanosine is a purine nucleoside SGTC_1161 k007-0610 110 µM -1.15329024721196 0.161122650238807 no 2800 0.124395635917558 947 5843850 SGTC_4 0960-0234 25.671 µM -1.15454416894388 0.160881694737152 no 2801 0.12413857056788 944 6821112 SGTC_2641 levomentholum 100 µM -1.15527658479715 0.160741061481409 no 2802 0.123988590719166 961 16666 SGTC_917 harmaline 728.087 nM -1.15734763278032 0.160343828216827 no 2803 0.123565179984961 939 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_530 4358-1714 28 µM -1.1600883096989 0.159819145138072 no 2804 0.123006426644122 944 1564641 SGTC_2321 7390090 138.78 µM -1.16118669584679 0.159609182552154 no 2805 0.122782991984411 983 649046 SGTC_1791 st048313 56.1 µM -1.16715805863757 0.158470883411809 no 2806 0.121573272493291 931 1204976 SGTC_467 ro 31-8220 72.8 µM -1.16844343950709 0.158226554121205 no 2807 0.121313970715925 970 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3249 9135183 49.47 µM -1.17226108902607 0.157502341340729 no 2808 0.120546124338969 939 4902779 SGTC_2545 solidagenone 89.61 µM -1.1730645919019 0.157350193787588 no 2809 0.120384952168971 913 6708572 An anti ulcer agent SGTC_3253 9135987 49.47 µM -1.17392812438433 0.157186787055895 no 2810 0.120211908126772 969 4182430 SGTC_1748 st037455 53.6035 µM -1.17413782535751 0.157147122069356 no 2811 0.120169912422528 985 580690 SGTC_1799 st045822 46.1415 µM -1.1768066378509 0.156642890574515 no 2812 0.119636346307572 927 3674992 SGTC_1605 st000082 49.1 µM -1.1785166505155 0.156320370146413 no 2813 0.119295349165744 938 1114022 SGTC_641 4092-0595 30 µM -1.17895894269093 0.156237021975913 no 2814 0.119207262535267 987 786260 SGTC_1606 st000094 49.2 µM -1.18129184750069 0.15579788005636 no 2815 0.118743402410603 958 1242210 SGTC_670 4204-0025 119 µM -1.18202050855316 0.155660885133324 no 2816 0.118598781705352 971 719039 SGTC_2100 5377183 190 µM -1.18238360181081 0.155592649956575 no 2817 0.118526763399926 946 2844202 SGTC_1642 st009582 77.7 µM -1.18803166617257 0.15453376461245 no 2818 0.117410467097678 971 6739311 SGTC_3129 9127257 49.47 µM -1.18976823776144 0.154209156034636 no 2819 0.117068748334749 971 837894 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.19388185172263 0.153442019557813 no 2820 0.116262093772396 933 6708630 An antioxidant. SGTC_2532 xanthone 78.9 µM -1.19629258885463 0.15299362462264 no 2821 0.115791199929461 988 7020 An insecticide. SGTC_967 1306-0166 352 µM -1.19666571342529 0.152924301496799 no 2822 0.115718438018062 967 4437607 SGTC_3061 glucosamine 200 µM -1.19697136057467 0.152867530577512 no 2823 0.115658858879229 950 91431 and experimental redox chemotherapeutic SGTC_101 0490-5701 117.494 µM -1.19842983913956 0.152596825155903 no 2824 0.115374860868297 948 4661669 SGTC_869 0564-0080 44.1 µM -1.19849659863157 0.152584441670957 no 2825 0.11536187319223 965 6843321 SGTC_2740 felodipine 17.08 µM -1.19892097949804 0.152505737159328 no 2826 0.115279336626874 964 3333 L-type calcium channel blocker SGTC_2049 5262831 67.185 µM -1.19931688287049 0.152432338297722 no 2827 0.115202376416754 960 763417 SGTC_1766 st045414 44.774 µM -1.199720846353 0.152357469294052 no 2828 0.115123887046837 953 253960 SGTC_647 0140-0236 81 µM -1.2015501314364 0.152018742355776 no 2829 0.114768936226912 993 990837 SGTC_254 nsc-64875 3.808 µM -1.20485976957904 0.151407171939446 no 2830 0.114128720793387 982 56993 SGTC_829 1635-0120 117 µM -1.2056893212541 0.151254140288366 no 2831 0.11396865202598 958 285054 SGTC_1985 st071382 65.5 µM -1.20736268587086 0.150945759330475 no 2832 0.113646249566118 1000 6123237 SGTC_2106 5357045 167.29 µM -1.20754170743117 0.150912792608321 no 2833 0.113611796523581 972 668842 SGTC_246 cycloheximide 667 µM -1.20770374058799 0.150882958423445 no 2834 0.113580619352479 965 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1321 1326-2144 215 µM -1.21560847869967 0.149432274049047 no 2835 0.112067051375592 993 3513030 SGTC_3244 9134489 49.47 µM -1.21723338490418 0.149135227316579 no 2836 0.111757715720215 988 16584271 SGTC_2770 toltrazuril 17.5 µM -1.21877126599178 0.148854453014126 no 2837 0.111465510164402 942 68591 Kills coccidiodes. SGTC_322 k048-0136 19.3 µM -1.22003186708408 0.148624565937443 no 2838 0.111226397377493 992 6823282 SGTC_1871 st057448 67.3 µM -1.22280913271532 0.148118933151803 no 2839 0.110700897612638 991 691747 SGTC_2666 tannic acid 100 µM -1.22361445030162 0.147972531469935 no 2840 0.110548852897896 964 16134267 A thiamine antagonist. SGTC_2905 7799065 20.05 µM -1.22413162235962 0.147878563928368 no 2841 0.110451289296461 951 1296806 SGTC_1883 5-benzylidenerhodanine 20 µM -1.2247397788078 0.14776811610551 no 2842 0.110336640645001 957 1273210 SGTC_3320 9137005 35.139 µM -1.2275657423924 0.147255615244464 no 2843 0.109805014229868 982 4908713 SGTC_2724 maprotiline 69.64 µM -1.22914702656267 0.146969362905043 no 2844 0.109508343052645 959 4011 A tricyclic antidepressant. SGTC_2139 5578692 56.4705 µM -1.22975594361051 0.146859233139676 no 2845 0.109394255284794 938 650991 YMR113W FOL3 SGTC_2041 5107442 45.335 µM -1.23039243009329 0.14674417630687 no 2846 0.10927509334533 977 793005 SGTC_643 k048-0106 28.4 µM -1.23044258587896 0.146735112282168 no 2847 0.10926570722798 988 6763920 SGTC_1917 st066507 28.5 µM -1.2305831885079 0.14670970493891 no 2848 0.109239398041825 971 3156428 SGTC_1194 1488-0194 225 µM -1.23092920357942 0.146647191483797 no 2849 0.109174672014626 976 1391452 SGTC_878 0828-0289 13.7 µM -1.2342690503536 0.146044710876934 no 2850 0.108551332328248 964 745350 YLR208W SEC13 SGTC_1611 st001856 99.4 µM -1.23464819091773 0.145976422321936 no 2851 0.108480732730644 1001 647478 SGTC_2338 7999974 200 µM -1.23533146843505 0.145853408599641 no 2852 0.108353583348134 965 315925 SGTC_646 4092-0839 27.3 µM -1.23772493690488 0.145423050595896 no 2853 0.107909034728016 978 877796 SGTC_1268 0828-0275 2.46 µM -1.23819464787686 0.145338694492366 no 2854 0.107821947799321 981 745337 SGTC_1888 azatryptophan 97.5 µM -1.23883580273191 0.145223601666297 no 2855 0.10770315598452 976 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3034 9090421 49.47 µM -1.23952017919368 0.145100817873496 no 2856 0.107576460229886 963 17173761 SGTC_561 1550-0330 72.9 µM -1.24283316063095 0.144507424737906 no 2857 0.106964660034973 980 6812934 SGTC_1130 3454-2858 15.9 µM -1.24431115716382 0.144243226700387 no 2858 0.106692533158536 980 715628 YIL048W NEO1 SGTC_760 0568-0725 82.9 µM -1.24501382636802 0.144117735924689 no 2859 0.106563333964766 991 3916171 SGTC_2953 9074162 66.49 µM -1.24517941525318 0.144088173871882 no 2860 0.106532903726588 958 16451992 SGTC_1393 3470-5649 58.2 µM -1.24891238952113 0.143422823026834 no 2861 0.10584855978245 967 4108395 SGTC_3187 9109394 49.47 µM -1.25042897153779 0.143153106827487 no 2862 0.105571443413005 976 17098090 SGTC_2226 7298446 200 µM -1.25129141027784 0.142999879517632 no 2863 0.105414089105877 985 3283010 SGTC_2262 9014885 67.46 µM -1.25162439626556 0.142940748404547 no 2864 0.105353380319543 998 6457424 SGTC_1959 st077091 55.8 µM -1.25390664341618 0.142535915402365 no 2865 0.104937970024129 967 821356 YKL052C ASK1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.25532215012994 0.142285217833465 no 2866 0.104680918712786 993 689007 SGTC_3136 9095672 49.47 µM -1.25616226781509 0.142136567431333 no 2867 0.104528571955669 932 17217380 SGTC_2147 5545932 89.7195 µM -1.2567238662245 0.142037256858323 no 2868 0.104426821438757 1012 797404 SGTC_468 gf-109203x 121 µM -1.25902988658585 0.141629962934622 no 2869 0.104009768565465 1013 2396 A protein kinase C inhibitor. SGTC_271 rotenone 740 µM -1.25982047305277 0.141490510276128 no 2870 0.103867066268116 998 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1830 st055982 50.3 µM -1.26179065707845 0.141143391707029 no 2871 0.103512062481078 995 455313 An antimicrobial agent. SGTC_493 zm226600 134 µM -1.26289391449583 0.140949265763839 no 2872 0.103313653622293 987 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3297 9117502 71.43 µM -1.26391547634785 0.140769676292311 no 2873 0.103130183149538 981 7453720 SGTC_2368 9071271 200 µM -1.26854108631299 0.13995844275828 no 2874 0.102302393976475 990 27209959 SGTC_334 1502-1024 68.5 µM -1.26898705261651 0.139880398016952 no 2875 0.102222840954983 996 3296216 SGTC_2948 9070189 9.45 µM -1.26946412427513 0.139796942545518 no 2876 0.102137789078428 942 6473636 YDL196W YDL196W SGTC_1345 1488-0192 31.4 µM -1.27372417493319 0.13905322064238 no 2877 0.101380592861328 993 658348 SGTC_2303 7774051 200 µM -1.27561425373529 0.138724113813089 no 2878 0.101045956465017 989 2953184 SGTC_3204 9114183 49.47 µM -1.27902990238057 0.138130716321769 no 2879 0.100443263057444 966 17027248 SGTC_3162 9099653 49.47 µM -1.27921622220168 0.138098397008547 no 2880 0.100410462410834 972 25237511 SGTC_56 0957-0365 83.25 µM -1.28003832106903 0.137955856092632 no 2881 0.100265829458195 989 6752360 SGTC_3309 9129340 25.759 µM -1.28007334082397 0.137949786366245 no 2882 0.100259671764356 988 17158987 SGTC_642 0335-0876 158 µM -1.28035144303642 0.137901591344401 no 2883 0.100210781499134 998 6812350 SGTC_3048 9093155 49.47 µM -1.28204336515312 0.137608629322502 no 2884 0.0999137171859812 962 25236002 SGTC_1715 st032160 10.2275 µM -1.28228915291654 0.13756610570687 no 2885 0.0998706158185419 977 5289825 SGTC_1218 1348-1416 30.7 µM -1.2848265062355 0.137127643764641 no 2886 0.0994264588174869 974 6787668 SGTC_2430 5571206 200 µM -1.28498584088721 0.137100142173476 no 2887 0.0993986159661716 986 1731771 SGTC_408 cantharidin 100 µM -1.28875541827009 0.13645060195803 no 2888 0.0987415647167132 984 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3210 9128157 49.47 µM -1.28994626316473 0.136245844340811 no 2889 0.0985346582084418 982 17590849 SGTC_1636 st007707 68.9 µM -1.29478083237811 0.135416733395218 no 2890 0.0976979230054225 994 403051 SGTC_1246 0422-0085 105 µM -1.29560805952628 0.135275214146983 no 2891 0.0975552755153823 978 264295 SGTC_3168 9103419 49.47 µM -1.29672807413932 0.135083767413022 no 2892 0.0973623830836166 999 16649256 SGTC_1731 st035964 63 µM -1.30025806819167 0.134481593230898 no 2893 0.0967562672210684 1002 6739575 SGTC_729 4092-0585 94.1 µM -1.30172608242165 0.13423171117709 no 2894 0.0965050200395301 977 2169061 SGTC_824 1304-0008 100 µM -1.302464372748 0.134106161667542 no 2895 0.096378844685875 997 768245 SGTC_3158 9100007 49.47 µM -1.30450796934172 0.13375905989984 no 2896 0.0960302220516028 1001 19297233 SGTC_2707 st078556 66.6 µM -1.30780199275327 0.133200876029002 no 2897 0.0954702390736313 965 17250899 SGTC_151 3013-0144 2.285 µM -1.30798422977853 0.133170042184625 no 2898 0.0954393291449478 987 906558 YHR107C CDC12 SGTC_1385 3091-4834 14.1 µM -1.30951158889048 0.132911811656732 no 2899 0.0951805573834699 991 4072814 SGTC_2024 5144227 134 µM -1.30964834398965 0.132888707306889 no 2900 0.0951574129718667 989 3475211 SGTC_2401 5128683 200 µM -1.31040275015016 0.132761302431506 no 2901 0.0950298118817407 1005 708373 SGTC_1035 k081-0041 55.2 µM -1.31055416312281 0.132735741795188 no 2902 0.0950042169181658 986 731709 SGTC_2309 7664088 163.95 µM -1.31267793184463 0.132377576970712 no 2903 0.0946457484280251 973 704922 SGTC_2745 rifampicin 24.3 µM -1.315593006671 0.131887047053016 no 2904 0.0941553410270178 975 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.31643919001366 0.131744891905398 no 2905 0.0940133380025714 976 17037758 SGTC_294 k038-0071 157 µM -1.32010024690915 0.131131068571316 no 2906 0.0934007751782264 1000 24152826 SGTC_3084 9116877 49.47 µM -1.3203331139846 0.131092092342098 no 2907 0.0933619121554993 982 27241325 SGTC_2356 9061756 188.97 µM -1.32187336145607 0.130834494274904 no 2908 0.0931051621073441 989 20104043 SGTC_163 TUB2.036 7.546 µM -1.32742386297694 0.12990910587493 no 2909 0.0921842551299361 969 15992207 YJR013W GPI14 SGTC_2971 9092186 9.93 µM -1.3277251787009 0.129859000038156 no 2910 0.0921344562223719 989 25236400 SGTC_276 colchicine 750 µM -1.32825517713064 0.129770898990638 no 2911 0.0920469109057805 1003 2833 A microtubule depolymerizer. SGTC_1097 itavastatin 7.23 µM -1.33232200082776 0.129096252726306 no 2912 0.0913772002998941 989 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_487 nimodipine 119 µM -1.33293232126753 0.128995216773704 no 2913 0.0912770073291444 1023 4497 L-type voltage-gated calcium channels inhibitor SGTC_3060 1327-0027 12.5 µM -1.33321714792021 0.128948083704836 no 2914 0.0912302767801701 968 16000455 YPR107C YTH1 SGTC_2103 5378138 10 µM -1.33405108985895 0.128810151811083 no 2915 0.0910935567458358 981 244142 SGTC_2166 5933061 31.504 µM -1.33430740587044 0.128767778359874 no 2916 0.0910515657403897 1004 2877375 SGTC_1924 st058459 75.1 µM -1.33596549156462 0.128493901856035 no 2917 0.0907802764055085 983 688683 SGTC_1104 tacrolimus 29.8 µM -1.33771400233163 0.128205527550802 no 2918 0.09049484234902 969 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1171 0368-0077 21.4 µM -1.33805511273223 0.128149322124869 no 2919 0.0904392358487194 998 3239779 SGTC_112 phenothiazine 287.218 µM -1.33903448548993 0.12798804408024 no 2920 0.0902797232780006 997 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2456 5770359 74.46 µM -1.34703554518826 0.126675752177946 no 2921 0.0889843925128393 1003 3118787 SGTC_1387 3342-1166 1.8 µM -1.34830499337856 0.1264684083186 no 2922 0.0887801533787093 975 3418228 SGTC_1234 0326-0494 15.5 µM -1.34859012844859 0.12642186864606 no 2923 0.0887343265795154 1002 1547813 SGTC_635 k038-0028 24.7 µM -1.35085330052565 0.126052897489894 no 2924 0.0883712150717615 1011 4035102 SGTC_601 0986-0029 62.9 µM -1.35087288513357 0.126049707837537 no 2925 0.0883680776860838 974 24747981 SGTC_1018 4259-0013 28.1 µM -1.35479911446353 0.125411397574527 no 2926 0.087740784416978 997 6801262 SGTC_1798 st045719 60.953 µM -1.35759240978998 0.12495865087335 no 2927 0.087296526376675 969 3980186 SGTC_1831 st055328 12 µM -1.36041318632398 0.124502609884622 no 2928 0.0868496039945775 993 1103068 SGTC_423 5-fluorouracil 457 µM -1.36277514817584 0.124121642578914 no 2929 0.0864766928499902 983 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1657 st012939 43.4 µM -1.36622515786437 0.123566647952641 no 2930 0.0859341517305639 990 24207257 SGTC_203 k066-0004 30.888 µM -1.36752347900643 0.123358240962791 no 2931 0.0857306415346822 1035 6795412 SGTC_2955 9076254 12.21 µM -1.37032012327136 0.122910159457736 no 2932 0.085293497034973 996 16459619 SGTC_500 h-89 112 µM -1.37451641384975 0.12223996799055 no 2933 0.0846407090608369 1016 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2485 5633444 17.78 µM -1.37774190898633 0.121726569493674 no 2934 0.0841414935599964 995 5724239 SGTC_2983 9022671 12.99 µM -1.37868719334661 0.121576397117728 no 2935 0.0839956098761312 990 6405161 SGTC_1498 4478-3555 97.6 µM -1.38101511334856 0.121207127995691 no 2936 0.0836371568892409 1012 3437919 SGTC_477 mead ethanolamide 10 µM -1.38296222407142 0.120898871606836 no 2937 0.0833382245844104 1011 16061185 SGTC_1213 1315-0166 115 µM -1.38379560184063 0.120767104332906 no 2938 0.0832105250740619 988 768401 SGTC_3300 9124615 50.48 µM -1.38419011165126 0.120704762745743 no 2939 0.0831501251790044 1003 24824903 SGTC_971 1315-0384 26.7 µM -1.38439525927016 0.120672353677315 no 2940 0.0831187298802323 1025 6769120 SGTC_3096 9117468 49.47 µM -1.38441665518599 0.120668973919238 no 2941 0.0831154560140851 982 41316311 SGTC_1909 st060837 51.5 µM -1.38589507264856 0.120435600378519 no 2942 0.0828894728097517 979 678937 SGTC_2428 5615643 7.78 µM -1.38796383471792 0.120109572708606 no 2943 0.0825740289738462 995 2253075 SGTC_2519 cryptotanshinone 88.04 µM -1.38909142324357 0.119932131909515 no 2944 0.0824024757415193 996 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2355 9061122 103.12 µM -1.38921146074203 0.119913253328179 no 2945 0.082384228849156 1032 5302957 SGTC_3329 9141233 27.5565 µM -1.39144764052614 0.119561947015779 no 2946 0.0820448633256616 976 4909101 YNL103W MET4 SGTC_2876 9059903 25.97 µM -1.39294284145925 0.119327454686762 no 2947 0.081818537958897 1002 6916095 SGTC_3242 9133940 49.47 µM -1.39392406457032 0.11917374597742 no 2948 0.081670268249426 1012 17248444 SGTC_1292 0kpi-0043 232 µM -1.39578014772235 0.118883372699977 no 2949 0.0813903551718889 1010 3333905 SGTC_1280 0880-0253 10.1 µM -1.40590041318905 0.117308906677136 no 2950 0.0798768493088151 1003 6836607 SGTC_2233 sulbentine 40.3845 µM -1.40632510974493 0.117243158693284 no 2951 0.0798138036092769 979 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_992 3909-8734 162 µM -1.40693601844707 0.117148628680515 no 2952 0.0797231809545086 1024 4288319 SGTC_932 2857-0803 154 µM -1.40915444433012 0.116805810820263 no 2953 0.0793947524594622 1014 674898 SGTC_862 0452-0056 10.2 µM -1.40956765889871 0.116742034582372 no 2954 0.0793336911042697 1031 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_533 1222-0222 6.71 µM -1.40966613765314 0.116726838847897 no 2955 0.0793191439935037 1019 3982874 SGTC_605 1315-0399 119 µM -1.41099198236874 0.116522391303712 no 2956 0.0791234890594777 1010 24020461 SGTC_1076 itraconazole 331 nM -1.41275446305091 0.116251007134045 no 2957 0.078863965841384 1014 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2524 avocatin b 10.57 µM -1.41385349560197 0.116082006931651 no 2958 0.0787024613390077 1017 6710748 SGTC_3018 9082602 49.47 µM -1.4169147233102 0.115612196041571 no 2959 0.0782539306539539 984 17332089 SGTC_2278 7948257 134.34 µM -1.41999860796886 0.115140275374382 no 2960 0.0778040431565485 1006 1247028 SGTC_2140 5586273 200 µM -1.42016934251136 0.115114188282013 no 2961 0.0777791932948539 1012 854421 SGTC_549 1661-1316 519 µM -1.4207594074151 0.115024062685381 no 2962 0.0776933576382342 1015 2857282 SGTC_1206 3978-0017 132 µM -1.42414686419918 0.11450763867685 no 2963 0.0772019813517131 992 3873677 SGTC_505 gw-5074 63.9 µM -1.42659156788602 0.114135965856409 no 2964 0.0768488280568363 1017 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1033 k072-0102 21.3 µM -1.42690764180734 0.114087975354994 no 2965 0.0768032589334661 993 5965931 SGTC_2651 TUB2.036 5 µM -1.42845090523906 0.113853863220333 no 2966 0.0765810579994763 981 15992207 YFL037W TUB2 SGTC_2404 5161160 200 µM -1.43144840957811 0.113400122301845 no 2967 0.0761508713508756 995 2831543 SGTC_1716 st033144 30.6155 µM -1.43166105235188 0.113367983008705 no 2968 0.0761204239499755 1016 674617 SGTC_2768 sulfasalazine 50.2 µM -1.43204438097271 0.113310062297047 no 2969 0.0760655601905244 1024 5384001 An antioxidant and salicylic acid derivative. SGTC_1423 4048-0112 5.59 µM -1.43472903590632 0.112905004189769 no 2970 0.0756821633699482 1008 X1423 SGTC_1328 1441-0025 69.2 µM -1.43525985606642 0.112825037106268 no 2971 0.0756065313126567 1006 4562601 SGTC_2190 6049624 200 µM -1.43631465107584 0.11266625419795 no 2972 0.0754564134524305 997 2265554 SGTC_306 1672-3436 11.6 µM -1.43961660664738 0.112170228246028 no 2973 0.0749879493172339 1020 6797378 SGTC_2580 diallyl disulphide 81.36 µM -1.44024751472193 0.112075629940115 no 2974 0.0748986923497501 1006 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2910 7948405 25.97 µM -1.44041215310137 0.112050953460812 no 2975 0.0748754136706453 972 2971328 SGTC_893 0958-0369 48.9 µM -1.44109648906845 0.111948424822965 no 2976 0.0747787126499281 1014 6819948 SGTC_2046 4110841 106 µM -1.44259313887653 0.111724427459542 no 2977 0.0745675586422134 998 44119630 YMR134W ERG29 SGTC_1579 chlormadinone acetate 49.4 µM -1.449380048751 0.110712682287053 no 2978 0.0736157386213618 1019 45114258 A steroidal progestin. SGTC_2221 6807166 181.081 µM -1.44949764141264 0.110695210448504 no 2979 0.073599329266065 1011 674925 SGTC_2396 5342950 42.78 µM -1.45048863879734 0.110548047212725 no 2980 0.0734611525587245 981 1886677 SGTC_567 1080-0542 68.4 µM -1.45226788308149 0.110284181247408 no 2981 0.073213567008873 988 5950415 SGTC_97 0535-0701 19.132 µM -1.4555747816939 0.109794961166773 no 2982 0.0727551018002345 983 2832013 YGL099W LSG1 SGTC_2879 9041815 71.43 µM -1.45584934425846 0.109754412734022 no 2983 0.0727171357698751 1014 4942971 SGTC_1796 st049173 110.4 µM -1.45821503615738 0.109405483720928 no 2984 0.0723906402774678 1008 94134 SGTC_1482 3346-2049 8.48 µM -1.45932360719092 0.109242248886152 no 2985 0.0722380304273459 1017 3826804 SGTC_3269 9137823 49.47 µM -1.46124270774122 0.108960079026106 no 2986 0.0719744232362854 980 17682936 SGTC_977 1348-1378 135 µM -1.46344554206298 0.108636837399667 no 2987 0.0716727523431301 1000 X977 SGTC_3188 9110789 49.47 µM -1.46596297116437 0.108268277622525 no 2988 0.0713291874705354 1020 849217 SGTC_1463 k081-0032 34.1 µM -1.46602741729963 0.10825885432767 no 2989 0.0713204088412739 946 977755 SGTC_2177 5811945 192 µM -1.46660602986473 0.1081742762099 no 2990 0.0712416293874484 1008 5343475 SGTC_1413 3910-0535 34.4 µM -1.4666858880144 0.108162606760476 no 2991 0.0712307617621415 1014 2876951 SGTC_2205 7238770 200 µM -1.46778402134308 0.108002231488153 no 2992 0.0710814495701901 1015 279867 SGTC_1649 st011737 51.3 µM -1.46939244625498 0.107767640596556 no 2993 0.070863187487521 967 1761035 SGTC_558 k064-0027 21.3 µM -1.47083676759979 0.107557297413272 no 2994 0.07066763322049 1013 5088526 SGTC_2982 9019404 25.97 µM -1.4710782243115 0.10752216184145 no 2995 0.0706349816256321 994 22333232 SGTC_1373 2887-0003 58.5 µM -1.47318258811967 0.107216295493027 no 2996 0.0703509043815907 1022 776948 SGTC_1137 ixabepilone 100 µM -1.47511181524068 0.106936436696819 no 2997 0.0700912422196692 1009 154225 A novel microtubule stabilizer. SGTC_1652 st011932 78 µM -1.47670958671186 0.106705058990409 no 2998 0.0698767506360633 1005 1551076 SGTC_2932 9016711 44.54 µM -1.47717144908646 0.106638242787304 no 2999 0.0698148424890457 1023 7117328 SGTC_281 1672-3440 14.9 µM -1.47766213287542 0.106567290168782 no 3000 0.0697491173689735 1024 6833000 SGTC_50 0929-0078 56.389 µM -1.47914277918076 0.106353396071239 no 3001 0.0695510794290046 978 1377751 SGTC_1795 st049545 62.3 µM -1.48071001651766 0.106127330974154 no 3002 0.0693419318322315 986 5291882 SGTC_1828 st055811 49 µM -1.48158770276857 0.106000881453254 no 3003 0.0692250165349832 1024 5877589 SGTC_2432 5630864 12.22 µM -1.48194136419843 0.105949959726597 no 3004 0.0691779487663347 1018 5714970 SGTC_2131 toluylene red 5.2905 µM -1.48628964124038 0.105325320037382 no 3005 0.0686012627429508 988 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_959 1222-0044 107 µM -1.4867532450275 0.105258879817644 no 3006 0.0685399971278381 1005 6083612 SGTC_1088 bifonazole 369 nM -1.48723462174399 0.10518992461065 no 3007 0.0684764274776929 1022 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2591 skatole 100 µM -1.48870416056493 0.104979621528263 no 3008 0.0682826444682916 1019 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_939 1165-0479 45.3 µM -1.49226565435963 0.104471205539396 no 3009 0.0678147583993743 1003 1377347 SGTC_2717 st081029 62.2815 µM -1.49313784046586 0.104346970242342 no 3010 0.067700554541536 1010 5292846 SGTC_168 3970-0862 530.542 µM -1.49754648325154 0.103720635748688 no 3011 0.0671255600044671 1005 3135186 SGTC_2627 acetyl isogambogic acid 100 µM -1.50152663570969 0.103157523478842 no 3012 0.0666097013781365 1019 6857789 A caspase activator and apoptosis inducer. SGTC_1129 3453-1384 223 µM -1.50389128581396 0.10282402571839 no 3013 0.0663046805717118 1031 1084452 SGTC_1997 st073024 93.8 µM -1.50662959896915 0.102438808224809 no 3014 0.0659528130536649 1028 686268 SGTC_1377 2944-0135 198 µM -1.50699279548441 0.102387793779111 no 3015 0.0659062519487617 996 1894137 SGTC_2225 6654152 15.4 µM -1.51109951257931 0.101812250846851 no 3016 0.0653815494438021 996 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_206 4546-0025 72.014 µM -1.51407206746356 0.101397128730234 no 3017 0.0650037811050583 1026 6620745 YIL048W NEO1 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.51853504763734 0.100776183689857 no 3018 0.0644397855739168 1024 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2295 7971645 200 µM -1.51872443002852 0.100749895935574 no 3019 0.0644159373074052 1035 2978226 YKL099C UTP11 SGTC_2716 st080858 38.6235 µM -1.52182897666289 0.100319673336113 no 3020 0.064025969442425 1012 5296050 SGTC_1988 st071872 53.4 µM -1.52696918015745 0.0996103033866956 no 3021 0.0633843376564357 1027 16414116 SGTC_2490 carminic acid 95.39 µM -1.53148056469626 0.0989907393514282 no 3022 0.0628253330994565 1023 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3064 1327-0027 10 µM -1.54033935444752 0.0977823427977802 no 3023 0.0617388278338843 1010 16000455 YPR107C YTH1 SGTC_3293 9120939 62.045 µM -1.54095949488181 0.0976981583782896 no 3024 0.0616633222114172 1025 934087 SGTC_33 0986-0033 35.816 µM -1.54127325792167 0.0976555851157018 no 3025 0.0616251472561041 994 2848082 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.54485459208855 0.0971706115022271 no 3026 0.0611907194622233 989 4000243 SGTC_2357 9067248 200 µM -1.54548343102885 0.0970856387388881 no 3027 0.061114686799573 1046 9150235 SGTC_1015 4130-4525 82 µM -1.5504071720535 0.096422195783792 no 3028 0.0605219091084539 1028 1363237 SGTC_2311 7694451 200 µM -1.55131040200218 0.096300853740439 no 3029 0.0604136576113751 1028 2163142 SGTC_181 1447-1644 8.07 µM -1.55359800065018 0.0959940344850577 no 3030 0.0601401682640416 1036 534600 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.55448327120256 0.095875492593222 no 3031 0.06003459198971 1009 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2122 5258151 111.688 µM -1.55470100013367 0.0958463541687327 no 3032 0.0600086481557439 1042 2173356 SGTC_891 0929-0073 133 µM -1.55633864822511 0.0956273982426328 no 3033 0.0598137928883158 1039 5603632 SGTC_459 nigericin 15.3 µM -1.55944394912142 0.0952132260467492 no 3034 0.0594456705633945 1035 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2447 5741742 33.78 µM -1.56796997412573 0.0940828547365226 no 3035 0.0584440699195485 1024 1776504 SGTC_356 1634-0012 32.5 µM -1.56983760369757 0.0938365738064094 no 3036 0.0582264483952567 1031 735457 SGTC_1962 st076595 64.5 µM -1.57270367119985 0.093459556636821 no 3037 0.0578937246930771 1019 279619 SGTC_1066 ketoconazole 628 nM -1.57540195574275 0.0931056341055849 no 3038 0.0575818466322136 1033 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2074 5212007 75.395 µM -1.57601674123584 0.0930251340381487 no 3039 0.0575109725416841 1027 758611 SGTC_702 1488-0190 94 µM -1.57833540379911 0.0927219910570981 no 3040 0.0572442882754435 1022 949357 SGTC_515 4092-1064 102 µM -1.57912449139508 0.0926189921948072 no 3041 0.0571537525328985 1049 717353 SGTC_1597 7-benzyloxygramine 47.5 µM -1.58163974720561 0.0922912430708298 no 3042 0.056865917408533 1004 260807 SGTC_588 3970-1144 52.9 µM -1.58230536241873 0.092204654227076 no 3043 0.0567899385854408 1027 1888707 SGTC_2534 helenine 20.12 µM -1.5896541260203 0.0912526590139665 no 3044 0.0559563946918371 1016 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3042 9091578 49.47 µM -1.5921331755596 0.09093316023607 no 3045 0.0556773921003732 1016 25236497 SGTC_813 k007-0158 173 µM -1.59493576610555 0.0905729639133811 no 3046 0.0553633002754774 1035 6523916 SGTC_1079 idarubicin 2.36 µM -1.59923375439357 0.0900226343744949 no 3047 0.054884336414933 1022 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1794 st048918 76.9 µM -1.60287797658245 0.0895579650569334 no 3048 0.0544807984307258 974 672303 SGTC_135 0933-0004 26.348 µM -1.60841486159213 0.0888553823144836 no 3049 0.0538721744620144 1018 21230617 YGL099W LSG1 SGTC_38 0929-0051 58.268 µM -1.61079536543999 0.088554581633403 no 3050 0.0536121657919846 1032 1379719 SGTC_1214 0358-0031 63.7 µM -1.61226259751465 0.0883695602988321 no 3051 0.0534524043454683 1048 4301366 SGTC_1074 carmofur 3.8 µM -1.61910156220807 0.0875109505496483 no 3052 0.0527127063770024 1052 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2218 6965428 192.983 µM -1.61977742759498 0.087426437065189 no 3053 0.0526400483928185 1016 675684 SGTC_1881 5652484 16 µM -1.61978591843776 0.0874253757166583 no 3054 0.0526391361021314 1042 2255129 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.62578580106568 0.0866777973140977 no 3055 0.0519976149672528 1025 688788 SGTC_2697 mebhydrolin 72.4 µM -1.62814025085853 0.0863857444863702 no 3056 0.0517475752313518 1041 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2125 5246583 200 µM -1.63013865528557 0.0861384344176408 no 3057 0.0515360977719407 1050 835267 SGTC_2596 sinensetin 100 µM -1.63131070158435 0.0859936358971638 no 3058 0.0514123882135971 1023 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_751 0833-0568 350 µM -1.63133559437785 0.0859905625345979 no 3059 0.0514097633414103 1049 6954252 SGTC_556 4058-0063 51.5 µM -1.63507551846094 0.0855297499577473 no 3060 0.0510166087742039 1043 6615692 SGTC_1686 st019653 115.5 µM -1.63674996431841 0.0853240344270032 no 3061 0.0508413622009843 1058 97252 SGTC_1112 tnp00069 1.16933 µM -1.63690500159724 0.0853050059493063 no 3062 0.0508251603586421 1038 145826 SGTC_3086 9117350 49.47 µM -1.63693866681658 0.0853008744736901 no 3063 0.0508216427895277 1022 2679265 SGTC_2671 danthron 100 µM -1.63784626253882 0.08518954866157 no 3064 0.0507268841025946 1040 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2648 atorvastatin 78.68 µM -1.6400914007358 0.084914627509644 no 3065 0.0504930820656442 1041 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2164 5685496 200 µM -1.64235078856527 0.0846386334685695 no 3066 0.0502586636382163 1045 759046 SGTC_2847 9005661 71.43 µM -1.64589007746517 0.0842076472217257 no 3067 0.0498931960976984 1028 2991449 SGTC_3218 9131285 49.47 µM -1.65065169936174 0.0836304166481138 no 3068 0.0494048578718013 1034 17156417 SGTC_3142 9086498 49.47 µM -1.6581460670337 0.0827279365243795 no 3069 0.0486439937880015 993 25236367 SGTC_158 k038-0087 26.446 µM -1.65878317481143 0.0826515546015523 no 3070 0.0485797459621673 1019 X158 SGTC_2941 9056145 11.23 µM -1.6606237074988 0.0824311939724447 no 3071 0.0483945222645594 1032 2119517 SGTC_894 0960-0238 55.9 µM -1.66156476626418 0.0823186952962618 no 3072 0.0483000364146031 1036 6741907 YDL195W SEC31 SGTC_3058 9093861 49.47 µM -1.66702084656289 0.0816687266714796 no 3073 0.0477551298677699 1024 17217477 SGTC_2353 9059630 146.67 µM -1.67033221559368 0.0812761429595311 no 3074 0.0474268263345113 1055 4779114 SGTC_676 falcarinol 140 µM -1.6718356852518 0.0810983677950433 no 3075 0.0472783639427059 1028 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2597 laccaic acid a 100 µM -1.67331024232067 0.0809242965382986 no 3076 0.0471331185898031 1046 5491415 A textile dye. SGTC_746 1095-0025 46.6 µM -1.68413989780311 0.0796544896383215 no 3077 0.04607731764315 1037 6749286 SGTC_1656 st012921 11 µM -1.68528860021932 0.0795206903444009 no 3078 0.0459664520308269 1035 6732821 SGTC_2027 5150920 200 µM -1.68581698025087 0.0794592024945893 no 3079 0.0459155280898875 1006 786715 SGTC_1996 st072960 66.8 µM -1.68592645880067 0.0794464669219343 no 3080 0.0459049824934013 1037 1719405 SGTC_2650 prasterone 100 µM -1.68692870002833 0.0793299486116471 no 3081 0.0458085313540158 1046 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1133 3473-0247 50 µM -1.6871238961754 0.0793072706046455 no 3082 0.0457897655263237 1002 711311 SGTC_2084 5306078 60.6385 µM -1.68979134448145 0.0789978564207686 no 3083 0.0455339401593304 1053 679340 SGTC_1654 st012436 41.8 µM -1.69035377323841 0.0789327336277841 no 3084 0.0454801466220037 1057 4323132 SGTC_1490 4089-0339 670 nM -1.69147513230468 0.0788030145004077 no 3085 0.0453730466836791 1047 742542 SGTC_64 000l-0018 272.079 µM -1.69497387661068 0.0783993169332089 no 3086 0.0450401882680728 1017 6811119 SGTC_1043 0916-0009 19.3 µM -1.69941330445207 0.0778893394405521 no 3087 0.0446206684563804 1047 3101130 SGTC_1278 0874-0585 172 µM -1.70065366814725 0.0777473040792546 no 3088 0.0445040200217691 1057 766306 SGTC_566 0958-0068 16.5 µM -1.70480504229499 0.0772733558334883 no 3089 0.0441153954057144 1025 6815365 SGTC_2108 5365811 200 µM -1.70962866270074 0.0767254200228946 no 3090 0.0436672809511049 1035 780283 SGTC_2348 9022543 33.42 µM -1.71353312617808 0.0762840629046215 no 3091 0.0433072522432239 1015 3162678 YDL140C RPO21 SGTC_406 estrone 100 µM -1.72135650737732 0.0754055325322123 no 3092 0.0425930756880718 1040 5870 A steroid. SGTC_3012 9080433 71.4286 µM -1.72291467598465 0.0752314817622322 no 3093 0.0424519779809749 1030 17688859 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.72689589407608 0.0747881623499091 no 3094 0.0420931809860732 1008 279621 SGTC_1508 1080-0625 72.9 µM -1.73088361347999 0.0743461198743872 no 3095 0.0417362624152436 1009 767111 SGTC_2077 5212015 200 µM -1.73134274488669 0.0742953530640471 no 3096 0.0416953259382767 1039 780900 SGTC_1974 st069448 26.9 µM -1.73309313989228 0.0741020522260358 no 3097 0.0415395577419564 1044 6323587 YNR016C ACC1 SGTC_2196 6573537 42.6665 µM -1.74350829020377 0.0729598142935896 no 3098 0.0406224337277167 1061 2903087 SGTC_1976 st070609 63.5 µM -1.7453034634816 0.0727643051342128 no 3099 0.0404660296907776 1043 682556 SGTC_819 1013-0258 27.7 µM -1.75784330382972 0.071409783829957 no 3100 0.0393870874432887 1042 5753198 SGTC_1100 amiodarone 5.07 µM -1.75806655125328 0.071385845757801 no 3101 0.0393680931346953 1042 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_645 0845-0943 5.41 µM -1.76176359247949 0.0709903194064063 no 3102 0.0390546242069025 1041 1885106 SGTC_344 k064-0035 6.43 µM -1.77122659466026 0.0699855929693177 no 3103 0.0382615142369384 1018 5088750 SGTC_3117 9124945 49.47 µM -1.77882940584563 0.0691863261809684 no 3104 0.0376338673059719 1040 17592065 SGTC_113 0099-0221 2.5 µM -1.77901314362369 0.0691670976374436 no 3105 0.0376188035643244 1050 89219 SGTC_1416 3966-0321 25.3 µM -1.78663818678805 0.0683727466431338 no 3106 0.0369979927862383 1058 582530 YLR208W SEC13 SGTC_3183 9108214 49.47 µM -1.78898207905917 0.0681299877163413 no 3107 0.0368088508678799 1064 4974831 SGTC_2038 4100038 30.985 µM -1.79418883125895 0.0675931010149985 no 3108 0.0363915171002742 1016 3596803 SGTC_673 1082-0474 110 µM -1.79553483702619 0.0674548427471642 no 3109 0.0362842637358131 1038 3098046 SGTC_2659 sanguinarine 24.21 µM -1.7960228129946 0.0674047731205377 no 3110 0.0362454444626507 1000 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_71 0417-1750 47.813 µM -1.80378182194417 0.0666125005859807 no 3111 0.0356327583210637 1019 6811472 SGTC_329 k048-0121 21.3 µM -1.80508178500827 0.0664804691695533 no 3112 0.0355309424812132 1062 6832902 SGTC_204 PMA1.184 62.41 µM -1.81034880595897 0.0659475939559657 no 3113 0.0351208564415113 1065 2252213 YGL008C PMA1 SGTC_2275 7947463 200 µM -1.81053336441827 0.0659289819977653 no 3114 0.0351065575892244 1023 1225414 SGTC_943 3253-1379 105 µM -1.81347006029358 0.0656333757395139 no 3115 0.0348796761558906 1027 668464 SGTC_1975 st070967 30.8 µM -1.81547555288649 0.0654320951406296 no 3116 0.0347254297966023 1039 261391 SGTC_2310 7668677 200 µM -1.8181849205982 0.0651609310481126 no 3117 0.0345179369871329 1049 2197143 SGTC_2780 5215298 71.43 µM -1.82133629528431 0.064846627083563 no 3118 0.0342778762090952 1056 2834131 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.82137144296741 0.064843128260416 no 3119 0.0342752065381861 1056 1273210 SGTC_2048 5246248 200 µM -1.82339868747126 0.0646415714133884 no 3120 0.0341215144822069 1047 677046 SGTC_2384 9036245 200 µM -1.82933224353343 0.0640544291932124 no 3121 0.0336749255879755 1035 6462766 SGTC_3166 9102297 49.47 µM -1.83263092041597 0.0637298137718096 no 3122 0.0334287383247446 1051 25237072 SGTC_1323 1348-1351 11.2 µM -1.83542671749248 0.0634556888689318 no 3123 0.0332212440170295 1056 6989654 SGTC_3063 1327-0034 4 µM -1.83716043995255 0.0632861607936834 no 3124 0.0330931069154055 1040 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1509 1326-1131 80 µM -1.84531414413417 0.0624935941272089 no 3125 0.0324959270746865 1038 768313 SGTC_3197 9113331 49.47 µM -1.8537693336014 0.0616799172079547 no 3126 0.031886083782675 1029 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1608 st001473 40.5 µM -1.86625165222393 0.0604938419104554 no 3127 0.031003082785898 1054 7292267 SGTC_617 3770-0098 35 µM -1.8734748272902 0.059815688342878 no 3128 0.0305014228251555 1054 5962639 SGTC_909 3448-9333 149 µM -1.87549191524533 0.0596273800852686 no 3129 0.0303625403487158 1060 3344074 SGTC_2969 9091408 28.7 µM -1.87712620763807 0.0594751492193799 no 3130 0.0302503991138326 1051 4286311 SGTC_2810 7959871 45.46 µM -1.87910344119631 0.0592913815419612 no 3131 0.0301151851845519 1047 2974535 SGTC_2567 aureobasidin a 60 nM -1.88034001856854 0.0591766782799272 no 3132 0.0300308762878286 1043 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2491 paeonol 100 µM -1.88174376839183 0.0590466793142897 no 3133 0.0299354069856306 1070 11092 Increases levels of cortical cytochrome oxidase. SGTC_1493 4348-0038 111 µM -1.88810792258731 0.0584601135342755 no 3134 0.0295057317436481 1048 800424 SGTC_1946 st076057 65.1 µM -1.88817956956195 0.0584535361808398 no 3135 0.0295009238023224 1060 953009 SGTC_2843 9000894 45.46 µM -1.88860882504806 0.0584141417314126 no 3136 0.0294721318059532 1046 2242070 SGTC_1739 st037196 92.5 µM -1.88907448256493 0.0583714301065002 no 3137 0.029440924553601 1048 612214 SGTC_1207 2099-0101 141 µM -1.89350847258603 0.0579659578289317 no 3138 0.0291451412834038 1057 5837381 SGTC_3271 9137798 49.47 µM -1.8983745317713 0.0575235257405953 no 3139 0.0288233810591185 1032 6498326 SGTC_1255 0566-0045 221 µM -1.89988098723255 0.0573870955013803 no 3140 0.0287243698186705 1046 2788469 SGTC_1756 st041558 35.5 µM -1.90027386033548 0.0573515573312547 no 3141 0.0286985949214635 1054 3955792 SGTC_2718 lomofungin 53.02 µM -1.90159465913359 0.0572322086272843 no 3142 0.0286120833560248 1060 5351222 A RNA synthesis inhibitor. SGTC_1568 digitonin 820 nM -1.90317797557922 0.057089396261817 no 3143 0.0285086629976171 1039 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2096 5468907 200 µM -1.90752397001058 0.0566988367694855 no 3144 0.0282263850397801 1069 759785 SGTC_2616 abietic acid 100 µM -1.90855846317586 0.0566061812895578 no 3145 0.0281595372772617 1059 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_451 chloral hydrate 100 µM -1.90894173215263 0.0565718836985867 no 3146 0.0281348043597981 1048 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1634 st006576 41 µM -1.91094454215159 0.0563929245099259 no 3147 0.0280058540688376 1048 3915356 SGTC_1114 scopoletin 1.73284 µM -1.91095795692016 0.0563917273521172 no 3148 0.0280049920254195 1065 5280460 A coumarin with genotoxic properties. SGTC_3236 9132701 49.47 µM -1.91417252101374 0.0561054309939389 no 3149 0.0277990578137801 1067 24282524 SGTC_145 3737-0113 38.366 µM -1.93512267114221 0.0542675458869321 no 3150 0.0264876220392108 1054 6849351 SGTC_454 lyso-paf C-16 6.67 µM -1.93921468701861 0.0539141908279087 no 3151 0.0262376009806403 1061 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_372 0155-0182 15.9 µM -1.94454292547432 0.0534568181722967 no 3152 0.0259150071434697 935 771486 SGTC_1698 5-fluorocytosine 1.055 µM -1.94924211251037 0.053055999300624 no 3153 0.0256332589909738 1058 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1955 wogonin 32.4 µM -1.95006937028925 0.0529856853762243 no 3154 0.0255839256992461 1047 5281703 A flavanone. SGTC_1432 4049-0298 68.4 µM -1.95126942948277 0.052883816063867 no 3155 0.0255125018209191 1073 741646 SGTC_3277 9138724 49.47 µM -1.95600349710056 0.0524834701336512 no 3156 0.0252323710718602 1072 15943418 SGTC_109 0132-0036 33.701 µM -1.95973036027351 0.0521699960368942 no 3157 0.025013657313012 1036 67274 A color developer. SGTC_2436 5633522 8.09 µM -1.96729100137059 0.0515386245704095 no 3158 0.0245748359388806 1063 5724242 SGTC_1559 coumarin 343 70.1 µM -1.97178755138286 0.0511660190145426 no 3159 0.0243169320144914 1062 108770 A hepatotoxic, DNA x-linker. SGTC_398 bronopol 33.3 µM -1.97297113154478 0.0510682991289066 no 3160 0.024249425732386 1065 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1792 st045773 43.6 µM -1.97641493800426 0.0507848129079574 no 3161 0.0240539005314222 1057 2919270 SGTC_182 3448-4371 550.524 µM -1.97810905209442 0.0506458179021928 no 3162 0.0239582028052036 1056 3491403 SGTC_214 4373-3496 70 µM -1.97953562956576 0.050529008309671 no 3163 0.0238778661284236 1066 3779166 SGTC_410 α-linolenic acid 100 µM -1.98250578211875 0.0502864978786591 no 3164 0.023711330442158 1064 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_110 0850-0284 111.64 µM -1.98483812583133 0.0500967149708016 no 3165 0.0235812420904991 1052 3906265 SGTC_546 peri-Naphthalide 147 µM -1.98537329329076 0.0500532490205076 no 3166 0.0235514775172543 1058 223824 A penicillin ester. SGTC_1882 5615643 20 µM -1.98621989520369 0.0499845499838087 no 3167 0.0235044563397481 1043 2253075 SGTC_764 1951-2361 146 µM -1.992032963391 0.0495148665898014 no 3168 0.0231837206294536 1046 5438930 SGTC_1638 st008370 60.6 µM -1.99280031970688 0.0494531299017177 no 3169 0.023141658375651 1037 24207134 SGTC_762 1165-0429 115 µM -1.9974814321848 0.0490778464792299 no 3170 0.0228864547648307 1054 5967793 SGTC_3251 9135047 49.47 µM -2.0049470328964 0.0484840420845652 no 3171 0.0224843549232883 1075 17682963 SGTC_1053 3366-3204 134 µM -2.00538737978018 0.0484491976703326 no 3172 0.0224608249158927 1067 3632071 YPR165W RHO1 SGTC_513 4245-1575 41.7 µM -2.01350927067845 0.0478101007237571 no 3173 0.0220305403349551 1045 719745 SGTC_3292 9120825 59.784 µM -2.01522831032905 0.0476757019470133 no 3174 0.0219403662479167 1055 24824900 SGTC_2669 eugenol 100 µM -2.01669988647065 0.0475608910040628 no 3175 0.0218634208978254 1067 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1972 st070201 17.4 µM -2.01943723941221 0.0473479146087564 no 3176 0.0217208971387113 1073 2829099 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.02061280849586 0.0472566857889347 no 3177 0.0216599309924177 1028 688669 SGTC_2127 5253358 187.912 µM -2.03791867778947 0.0459299167196279 no 3178 0.0207790331751348 1068 20612 SGTC_202 3594-0513 34.79 µM -2.04619447034959 0.0453061109920826 no 3179 0.020368620589385 1080 708429 SGTC_1405 3909-7894 12 µM -2.05126756569404 0.0449270970294357 no 3180 0.0201204486189133 1031 7104060 SGTC_1451 4152-0210 104 µM -2.05183685623698 0.0448847247475652 no 3181 0.0200927600626359 1060 659563 SGTC_279 1273-0055 2.93 µM -2.0599884252493 0.0442815250236531 no 3182 0.0196998236841358 1077 2847562 SGTC_2602 kawain 100 µM -2.06285077333411 0.0440712733728566 no 3183 0.0195634041742471 1051 5369129 SGTC_1628 st004252 77.7 µM -2.06641278756233 0.0438107531734466 no 3184 0.0193947597574765 1060 692968 SGTC_107 0358-0022 2.6945 µM -2.07151617151651 0.0434396661198545 no 3185 0.0191552923942334 1075 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1758 st042942 75.2445 µM -2.07431563004367 0.0432371867256987 no 3186 0.0190250035750945 1066 669317 SGTC_2415 st077333 57.7 µM -2.08390416506545 0.0425494363184095 no 3187 0.018584442710462 1055 2766255 SGTC_198 3454-2873 16.191 µM -2.08425067869198 0.0425247487562331 no 3188 0.0185686855597236 1070 710957 SGTC_106 0092-0003 11.579 µM -2.08677663575625 0.0423451352933634 no 3189 0.0184541650357916 1063 1072148 SGTC_230 MPP+ 141.667 µM -2.08708342118039 0.0423233625303649 no 3190 0.0184402972085952 1076 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_41 0478-0632 82.643 µM -2.08768665824504 0.042280576812573 no 3191 0.0184130545622118 1047 3750424 SGTC_1461 k072-0203 53.8 µM -2.08855216357766 0.0422192503575575 no 3192 0.0183740275600188 1051 5418714 SGTC_2462 5162487 171.77 µM -2.09210102623305 0.0419685435090687 no 3193 0.0182147396928401 1072 2259986 SGTC_2143 5623677 140.463 µM -2.09674852897635 0.0416420481023374 no 3194 0.0180079210577992 1054 5375313 SGTC_2182 6325192 200 µM -2.09964910796058 0.0414393221094844 no 3195 0.0178798597438559 1053 736248 SGTC_2126 5251174 33.877 µM -2.10830395062321 0.0408391712577509 no 3196 0.0175023532266748 1065 790722 SGTC_683 panaxydol 45 µM -2.11228086554524 0.0405657753954489 no 3197 0.0173311830287199 1074 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1948 st076329 66.6 µM -2.1124094678441 0.0405569593970624 no 3198 0.0173256718137294 1069 24208413 SGTC_3032 9089427 49.47 µM -2.1148583030304 0.0403893824024825 no 3199 0.0172210129662669 1028 17173707 SGTC_2837 9008476 45.46 µM -2.11821923455304 0.0401603052890749 no 3200 0.0170782524695376 1058 2992805 SGTC_738 1315-0003 72.4 µM -2.12588444712272 0.0396418011201186 no 3201 0.0167564411020323 1079 6251474 SGTC_1403 3909-7815 62.9 µM -2.12631359672652 0.039612933481188 no 3202 0.0167385783339145 1079 6615483 SGTC_3302 9125395 16.351 µM -2.1330328685281 0.0391631729909005 no 3203 0.016461014998287 1063 17599668 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.13576604556293 0.0389814185654114 no 3204 0.0163492440119583 1052 6708739 YPR165W RHO1 SGTC_1406 3909-7906 11.9 µM -2.13929651919992 0.0387476616622445 no 3205 0.0162058307158221 1030 X1406 SGTC_1241 0364-0022 50.8 µM -2.14077220376718 0.0386502938075345 no 3206 0.016146206277324 1070 4563895 SGTC_2320 7373003 200 µM -2.14557737031204 0.0383346224382949 no 3207 0.0159533562509656 1048 5415828 SGTC_2109 5483026 200 µM -2.14687598629979 0.0382496726936464 no 3208 0.0159015779275716 1068 759335 SGTC_2930 9013230 14.89 µM -2.15054675587779 0.0380103770114082 no 3209 0.015755995879388 1051 2995857 SGTC_1893 st059353 36.1 µM -2.15258765649149 0.0378778608613527 no 3210 0.015675549743423 1071 3112488 SGTC_2004 4023728 41.89 µM -2.15838038641891 0.0375037899874085 no 3211 0.015449134690852 1060 360084 YDR527W RBA50 SGTC_2679 rapamycin 1 nM -2.17051625751613 0.0367298833715236 no 3212 0.0149838791944886 1024 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2179 6298986 200 µM -2.1772303070237 0.0363073702470478 no 3213 0.0147316940565089 1033 738374 SGTC_3207 9114163 49.47 µM -2.17851461751355 0.0362270040222999 no 3214 0.014683872583601 1067 849233 SGTC_245 methotrexate 289.6 µM -2.17947502753967 0.0361670012175809 no 3215 0.0146481989202115 1065 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1932 st074806 40.9 µM -2.18104535586393 0.0360690683295088 no 3216 0.0145900309652589 1058 17251235 SGTC_2919 7978188 46.38 µM -2.18480171001271 0.0358356857167966 no 3217 0.0144516943121309 1078 2980291 SGTC_1313 1220-0047 237 µM -2.18821747902165 0.03562453915009 no 3218 0.0143268822461684 1061 3528706 SGTC_3024 9090631 49.47 µM -2.18956892694524 0.035541281118979 no 3219 0.0142777573055727 1072 25236383 SGTC_3067 9117431 49.47 µM -2.19033922776516 0.035493896969463 no 3220 0.0142498219462971 1081 17150885 SGTC_1717 st033143 58.0435 µM -2.19998942454179 0.0349046537496181 no 3221 0.013903822677937 1069 674616 SGTC_352 k048-0007 5.11 µM -2.20397638857493 0.0346635643239399 no 3222 0.0137630023255005 1061 6811911 SGTC_3105 9121040 49.47 µM -2.21548733624404 0.0339751684217391 no 3223 0.0133633163071899 1063 41448907 SGTC_2852 9023854 51.95 µM -2.21560557705578 0.0339681559677009 no 3224 0.0133592632893851 1064 19798528 SGTC_376 3970-0862 59.1 µM -2.21871396508951 0.0337842347739445 no 3225 0.0132530951697817 1069 3135186 SGTC_610 4215-0184 155 µM -2.21973432897888 0.0337240394579588 no 3226 0.0132184035439749 1046 5605015 SGTC_907 3448-6986 75.5 µM -2.22129604254493 0.033632078706141 no 3227 0.0131654583682267 1066 590582 SGTC_540 1187-0821 17.3 µM -2.22505712073056 0.0334114562132535 no 3228 0.0130387018989621 1072 847520 SGTC_102 gallobenzophenone 83.616 µM -2.22599215323134 0.0333567931326987 no 3229 0.0130073535078754 1049 70837 SGTC_506 n9-isopropylolomoucine 153 µM -2.22629919728082 0.0333388590529546 no 3230 0.012997073609035 1079 6610355 SGTC_608 k048-0125 159 µM -2.22735245467831 0.0332773998603758 no 3231 0.0129618636860987 1074 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2816 7982706 58.44 µM -2.23213279296791 0.0329996314875107 no 3232 0.0128030938218428 1062 2981853 SGTC_1250 0485-0349 40.2 µM -2.24845944397066 0.0320653193115914 no 3233 0.0122734541897976 1065 6842794 YDL195W SEC31 SGTC_1407 3909-7909 12.3 µM -2.2732783462533 0.0306869503052069 no 3234 0.0115047057907565 1059 4411780 SGTC_953 1188-0045 9.7 µM -2.27740365529621 0.03046266827371 no 3235 0.0113810660142882 1064 6144426 SGTC_184 1494-0393 24.714 µM -2.28612796283949 0.0299928221061159 no 3236 0.0111233867673411 1077 3090647 SGTC_2488 5268135 45.7 µM -2.28966804822126 0.0298038930362815 no 3237 0.0110202834917986 1065 1270356 YLR208W SEC13 SGTC_2625 euphol 100 µM -2.290316970534 0.0297693683229074 no 3238 0.0110014743747576 1069 6708538 A triterpene alcohol. SGTC_639 0833-0042 114 µM -2.29241684043389 0.0296578759576034 no 3239 0.0109408005871731 1084 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1561 5-methoxyflavone 52.9 µM -2.32643778139038 0.027899306866256 no 3240 0.00999760402711262 1066 94525 SGTC_1746 st038117 42 µM -2.3381781079453 0.0273129676049104 no 3241 0.00968900533609522 1071 2898218 SGTC_2933 9026794 32.47 µM -2.33853838973301 0.0272951380871724 no 3242 0.00967966830520457 1072 17586027 SGTC_1790 st045711 43.5 µM -2.3407008443121 0.0271883270681268 no 3243 0.00962379137502155 1069 585119 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.34795035948593 0.0268327897309272 no 3244 0.00943851846617582 1066 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2678 equilin 100 µM -2.36355071588806 0.0260808555823356 no 3245 0.00905037449064076 1074 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2743 auranofin 4.32 µM -2.36490423193734 0.0260164554880066 no 3246 0.0090173669179861 1076 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_780 0109-0199 192 µM -2.36666889093579 0.0259326930803097 no 3247 0.00897449136578163 1077 610414 SGTC_2824 7998404 51.95 µM -2.3832249253994 0.0251577671046937 no 3248 0.00858085246680651 1081 837851 SGTC_2689 tacrolimus 100 µM -2.3851139393294 0.0250705958180828 no 3249 0.00853691618410773 1046 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.39156165162831 0.0247749615367955 no 3250 0.00838843302171972 1083 688798 SGTC_965 1291-5240 308 µM -2.39295221926747 0.024711587377991 no 3251 0.00835670873465558 1081 2834598 SGTC_910 3454-3003 490 µM -2.39337354720454 0.0246924125152688 no 3252 0.00834711741307794 1078 820824 SGTC_2612 dictamnine 15.46 µM -2.39439003698279 0.0246462028952652 no 3253 0.00832401730652068 1059 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2751 anetholtrithion 17.25 µM -2.40307306835858 0.0242544217370913 no 3254 0.00812896927308257 1084 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1476 4112-3294 3.34 µM -2.43045309905179 0.0230531158814986 no 3255 0.00753997881675954 1047 704369 SGTC_1927 st060202 13.8 µM -2.43071175871413 0.0230420104887493 no 3256 0.00753459870492387 1072 688887 SGTC_2111 5486399 200 µM -2.43384674014294 0.0229077698406543 no 3257 0.00746965954466674 1066 689674 SGTC_1844 rapamycin 4 nM -2.43796483663271 0.0227324336560816 no 3258 0.00738510534317102 1042 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3287 9117173 37.0625 µM -2.43934611880122 0.0226738766920795 no 3259 0.00735693389341839 1052 2789709 SGTC_768 0384-0033 77.3 µM -2.43963522336902 0.0226616367293743 no 3260 0.00735104956529901 1073 3965305 YMR134W ERG29 SGTC_3343 9148379 18.9835 µM -2.46594301707424 0.0215709073320345 no 3261 0.00683265358561505 1068 1955036 SGTC_1751 st044839 27.194 µM -2.46711407760772 0.021523404445277 no 3262 0.00681034781814529 1079 5291326 SGTC_1475 4092-1048 11.7 µM -2.48730145351468 0.0207183221967339 no 3263 0.00643581394033841 1087 2881759 SGTC_779 1360-0071 233 µM -2.48967241367883 0.0206254624710429 no 3264 0.00639304426384555 1078 7566 SGTC_694 1315-0438 43.2 µM -2.49156877666805 0.0205514445279077 no 3265 0.00635901707467938 1083 6793154 SGTC_810 3825-7150 143 µM -2.49568205319067 0.0203916702083521 no 3266 0.0062857613433868 1056 22330411 YGL099W LSG1 SGTC_68 0986-0284 82.829 µM -2.49573059214278 0.0203897910851352 no 3267 0.00628490136407428 1056 423278 YIL048W NEO1 SGTC_3108 9121785 49.47 µM -2.49605625229638 0.020377187365473 no 3268 0.00627913423805399 1036 17140271 SGTC_1143 3454-2408 5.08 µM -2.49917747032231 0.0202567243594307 no 3269 0.00622409770524505 1063 X1143 SGTC_462 ag-879 158 µM -2.50869081935866 0.0198932760483259 no 3270 0.00605897489679174 1081 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1315 1237-0019 3.69 µM -2.5116071194122 0.0197829758003405 no 3271 0.00600914025264121 1083 825140 SGTC_3316 9136639 10.545 µM -2.52368085373646 0.0193318303553022 no 3272 0.0058066653531063 1077 4903665 SGTC_2124 5246320 200 µM -2.52617245544912 0.0192398258396106 no 3273 0.0057656430214722 1080 579342 SGTC_490 phenamil 164 µM -2.52793777703006 0.0191748653183576 no 3274 0.00573673420729322 1014 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1322 1348-1070 12 µM -2.52794349904831 0.0191746550623533 no 3275 0.00573664071337437 1086 6758089 SGTC_2739 tacrine 100.86 µM -2.55429083945846 0.0182270740932918 no 3276 0.00532021683275908 1003 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1813 st051246 8.6015 µM -2.56197637737369 0.0179582970669856 no 3277 0.00520391986563253 1083 5291959 SGTC_403 arphamenine a 50 µM -2.5794462732321 0.0173598912061594 no 3278 0.0049479425399456 1080 5487158 An arginine aminopeptidase inhibitor. SGTC_3252 9135871 49.47 µM -2.58187835504712 0.0172779496171526 no 3279 0.00491321070307218 1088 17682838 SGTC_3137 9097352 49.47 µM -2.58624431794392 0.0171316806158909 no 3280 0.0048514063673433 1073 44120435 SGTC_756 0508-1999 28.3 µM -2.59498389109507 0.0168420635396279 no 3281 0.0047297676214842 1086 6753853 SGTC_3345 9148410 3.559 µM -2.59565093007881 0.0168201318295226 no 3282 0.00472059636926643 1078 4903596 SGTC_3069 9117009 49.47 µM -2.59782212576587 0.0167489137183456 no 3283 0.00469085391089394 1085 41904981 SGTC_1057 3448-5381 134 µM -2.60807708868364 0.0164160136638381 no 3284 0.00455262231649487 1064 5497911 SGTC_922 1866-0035 480 µM -2.62623305834299 0.0158405144571635 no 3285 0.00431678407330073 1068 3156169 SGTC_2913 7966556 36.57 µM -2.63289904896035 0.0156336052673073 no 3286 0.00423297532026022 1057 2976516 SGTC_1012 4112-3522 18 µM -2.63303019372474 0.0156295579668136 no 3287 0.00423134118804668 1084 3112398 SGTC_607 4491-0986 66.8 µM -2.63746229548726 0.0154933050776238 no 3288 0.00417644553661821 1052 698981 YDR232W HEM1 SGTC_525 k781-2675 26.7 µM -2.63948222161375 0.0154315469552901 no 3289 0.0041516389112511 1068 3651118 YDL195W SEC31 SGTC_3339 9145883 14.936 µM -2.64637410353708 0.0152224196574444 no 3290 0.00406798918620206 1061 2030670 SGTC_1455 4262-0120 131 µM -2.65329161460911 0.0150149674356957 no 3291 0.00398554861418781 1085 1529587 SGTC_2692 st077426 47.7 µM -2.66557886452213 0.0146524684215166 no 3292 0.00384279514060575 1086 25238571 SGTC_3319 9138450 16.7555 µM -2.69633027512458 0.013778080751865 no 3293 0.00350540576316423 1080 2029690 SGTC_367 0335-0881 7.1 µM -2.70910555117623 0.0134282802015313 no 3294 0.00337324364928871 1083 23828853 SGTC_1607 st000305 50.6 µM -2.7215940249538 0.0130937711838563 no 3295 0.00324839501902047 1088 5457690 SGTC_3308 9128332 17.569 µM -2.72636441403784 0.0129679085836185 no 3296 0.00320181278102171 1080 17332805 YDL196W YDL196W SGTC_1374 2889-5571 141 µM -2.72826068275468 0.012918168491921 no 3297 0.00318346352620643 1084 2853281 SGTC_1061 3448-9325 110 µM -2.73334790540944 0.0127855422705538 no 3298 0.003134703555844 1082 723482 SGTC_2973 9094665 17.96 µM -2.73819674691686 0.0126602288387988 no 3299 0.00308885527055027 1079 25237061 YIL048W NEO1 SGTC_1312 1218-2183 165 µM -2.75212755563613 0.0123060975392109 no 3300 0.00296047267689169 1083 6744073 SGTC_2849 9019321 12.99 µM -2.75681553365223 0.0121888713721912 no 3301 0.002918363428412 1074 16489627 SGTC_2271 7849410 118.62 µM -2.76485155529097 0.0119901757203445 no 3302 0.00284743525139151 1083 972430 SGTC_1458 k015-0034 6.33 µM -2.76910897355022 0.0118860511922597 no 3303 0.00281049156310832 1090 3598957 SGTC_1855 st056195 39.6 µM -2.7825165654928 0.0115632475900384 no 3304 0.0026969555808565 1072 4028379 SGTC_2483 5729050 27.16 µM -2.78496177670231 0.0115052043328686 no 3305 0.00267670166715089 1082 2865180 SGTC_1880 MG-132 525 µM -2.79748424765849 0.0112119017302793 no 3306 0.00257511392589648 1070 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_551 k048-0028 34.9 µM -2.79878993901114 0.0111816972060058 no 3307 0.00256472475184896 1076 6836383 SGTC_1560 lithocholic acid 53.1 µM -2.80950755870245 0.0109364292930601 no 3308 0.00248086770060778 1079 9903 A bile acid which acts as a detergent. SGTC_1195 1502-0147 41.1 µM -2.83872145357114 0.0102915078475104 no 3309 0.00226473385863807 1091 817940 SGTC_3073 9114972 49.47 µM -2.87698861123064 0.00949705855077455 no 3310 0.00200745042657633 1090 41905075 SGTC_2986 9022445 71.43 µM -2.88638414740485 0.00931040156386119 no 3311 0.00194848094089203 1084 6459286 SGTC_765 1319-0117 244 µM -2.89509754465397 0.00914017313607997 no 3312 0.0018952036353804 1082 3487746 YGL099W LSG1 SGTC_2794 7785382 27.27 µM -2.93790188404289 0.00834291358303269 no 3313 0.00165220791315235 1077 2205081 SGTC_1941 st076221 61.8 µM -2.94783973429341 0.00816679282745759 no 3314 0.00160001458395501 1077 2828568 SGTC_1404 3909-7820 48.3 µM -2.98116582219055 0.00759979891264916 no 3315 0.00143576629177101 1066 23741373 SGTC_470 aa-861 153 µM -2.99423953372478 0.00738701679902732 no 3316 0.00137564927098847 1091 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2350 9023895 38.85 µM -3.01293632448413 0.0070918424958241 no 3317 0.00129366599738543 1076 2997209 SGTC_1427 4048-4900 550 nM -3.01765753988555 0.00701897257701634 no 3318 0.00127368298097532 1089 24132586 SGTC_1620 st003704 16.5 µM -3.02473610879763 0.00691095605702555 no 3319 0.0012442507506135 1089 2834414 SGTC_1450 4112-4260 37.6 µM -3.03492232674848 0.00675809410998205 no 3320 0.00120298820551335 1088 1633175 SGTC_2965 9082772 38.63 µM -3.06938658940391 0.00626281967752097 no 3321 0.00107249414136332 985 16459634 SGTC_2817 7995342 71.43 µM -3.07863079320593 0.00613556349782102 no 3322 0.00103977111981159 1085 18879975 SGTC_2286 7945697 125 µM -3.08312488391954 0.00607452928280265 no 3323 0.00102419586970273 1081 1245733 SGTC_150 3970-0969 77.2 µM -3.08498929697624 0.00604936701887459 no 3324 0.00101779739138905 1090 6615640 SGTC_1040 k898-0338 155 µM -3.09009921823267 0.00598087604819327 no 3325 0.00100044821122667 1090 20969351 SGTC_1861 st057647 17.4 µM -3.11012718405573 0.0057190124998688 no 3326 0.00093503401451836 1092 688668 SGTC_1086 cerivastatin 2.18 µM -3.12699010804286 0.00550647624735344 no 3327 0.000883029347050102 1086 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_46 0329-0187a 2.197 µM -3.12882252050359 0.0054838090500854 no 3328 0.000877541410095603 1075 46494817 SGTC_3065 9113888 49.47 µM -3.15878082126496 0.00512480026557671 no 3329 0.000792152957122914 1084 16648368 SGTC_3262 9137218 49.47 µM -3.21298057075472 0.00452811416012438 no 3330 0.000656825879102414 1091 17650664 SGTC_1211 1056-0033 32.3 µM -3.23318239569368 0.00432209991046067 no 3331 0.000612096872781558 1084 6741922 SGTC_2820 7989630 71.43 µM -3.29349108306613 0.00375600601247344 no 3332 0.000494757401145385 1091 2984098 SGTC_1635 st007035 42.4 µM -3.35814636259824 0.00322379235440032 no 3333 0.000392335265717183 1088 3716403 SGTC_280 3448-3607 3.04 µM -3.40014789725407 0.00291544646774726 no 3334 0.000336747069658654 1078 626179 SGTC_2354 9060492 162 µM -3.40366407151105 0.00289088018468936 no 3335 0.000332442343314718 1088 6471895 SGTC_1332 1480-0653 17.5 µM -3.41476152281125 0.00281456550129566 no 3336 0.000319189385279786 1093 5749438 SGTC_183 3914-0051 30.55 µM -3.45863514287231 0.00253033573973452 no 3337 0.000271459911844058 1092 1596232 SGTC_3222 9128301 49.47 µM -3.46643877604679 0.00248258910861797 no 3338 0.000263700915815555 1078 4911358 SGTC_940 3232-1287 54.8 µM -3.51702767332892 0.0021923238732834 no 3339 0.000218204140327299 1093 1585493 YIL048W NEO1 SGTC_918 glabranin 770.725 nM -3.56487289105701 0.00194647293237564 no 3340 0.000182016282655995 1093 124049 Also referred to as licorice root. SGTC_3068 9116768 49.47 µM -3.56566328936526 0.00194263063085518 no 3341 0.000181468550840622 1088 41904888 SGTC_1081 sertraline 6 µM -3.60969588365771 0.00173915550194299 no 3342 0.000153278101476008 1095 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1269 0831-0796 3.05 µM -3.6143562152982 0.0017187964503268 no 3343 0.000150547428283621 1076 927758 SGTC_2799 7812892 81.82 µM -3.7128277012463 0.00133629358258493 no 3344 0.000102478212016802 1085 20205235 SGTC_2411 st077133 39.94 µM -3.79798909797587 0.00107004851785366 no 3345 7.29373689674387e-05 1085 1403142 YNL221C POP1 SGTC_2620 irigenin 100 µM -3.85790797168696 0.000912893733031793 yes 3346 5.71808445780977e-05 1086 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1174 0739-0097 51.1 µM -3.88012024225653 0.000860239037008289 yes 3347 5.22024190467966e-05 1094 728447 SGTC_2781 5567276 71.43 µM -3.97179545024522 0.00067115368147768 yes 3348 3.56664796078907e-05 1089 2853274 SGTC_1827 berberine 7.24 µM -3.99332474236594 0.000632703731752367 yes 3349 3.25766198640288e-05 1084 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1010 4112-3296 15.2 µM -4.00951964912529 0.000605132304677828 yes 3350 3.04211951540375e-05 1094 704384 SGTC_1209 2323-2347 50.3 µM -4.19439239475782 0.000359979667172264 yes 3351 1.36801997516801e-05 1093 5412760 SGTC_2413 inermin 26.06 µM -4.4998109020841 0.000146114303568849 yes 3352 3.40069690318915e-06 1091 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -4.89706272191626 4.16753659200711e-05 yes 3353 4.86398974188768e-07 1095 756377 SGTC_1829 berberine 14.4 µM -5.17616618708724 1.63294229405625e-05 yes 3354 1.13245864448864e-07 1086 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1786 berberine 21.6 µM -5.47152834667479 5.76191092174955e-06 yes 3355 2.23085479518967e-08 1087 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2858 9025781 8.96 µM -5.72838662956326 2.23283409923225e-06 yes 3356 5.06951383170193e-09 1094 4894980 YPL153C RAD53