SGTCid condition conc unit CCT3|YJL014W.score CCT3|YJL014W.strain.pval CCT3|YJL014W.strain.significant CCT3|YJL014W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1875 nocodazole 6 µM 22.5006205214834 6.82424116758063e-67 yes 1 2.04648058256239e-112 1 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2174 5790901 200 µM 12.2076192676322 4.58834855968775e-21 yes 2 1.41525400024137e-34 2 786020
SGTC_229 benomyl 22.8748 µM 9.91550882080892 1.63202185989796e-14 yes 3 1.78217817206423e-23 3 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2151 5563267 85.4165 µM 9.66792163280465 6.93721268971309e-14 yes 4 2.06336706978481e-22 4 5310824
SGTC_435 c-PAF 6.7 µM 8.40457323999908 6.43479874069415e-11 yes 5 2.14710121972678e-17 3 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 7.05263628262122 3.48492498583609e-08 yes 6 8.77796617165597e-13 4 1377
SGTC_1643 st009866 20.2 µM 6.90898149491883 6.39666134408262e-08 yes 7 2.4407281162935e-12 8 3156273 YOR207C RET1
SGTC_2023 5144124 124 µM 6.65397708531778 1.826281040537e-07 yes 8 1.42638554329572e-11 3 2830192
SGTC_2183 6420625 130.508 µM 6.52052164635818 3.11601367964094e-07 yes 9 3.50316474164737e-11 7 2897619
SGTC_124 0136-0217 7.121 µM 6.42353931115426 4.56516940679611e-07 yes 10 6.65708702010273e-11 6 3976905
SGTC_2089 5281248 129.67 µM 6.33837174819452 6.35615739976628e-07 yes 11 1.16103006922196e-10 4 2737878
SGTC_887 0885-0007 9.62 µM 6.25774767038732 8.66195938052522e-07 yes 12 1.95288540708991e-10 7 5719458
SGTC_1773 st048542 73.5835 µM 6.00750446658417 2.21126865813178e-06 yes 13 9.42003090631538e-10 11 3237138
SGTC_1307 1187-1599 12.2 µM 5.92736571266838 2.96300832938356e-06 yes 14 1.53916449871634e-09 1 1538471
SGTC_464 bw-b 70c 158 µM 5.66131051256348 7.62719849459445e-06 yes 15 7.51106608948921e-09 2 5353454
SGTC_2254 7938975 95.19 µM 5.65537351326318 7.78628649709875e-06 yes 16 7.77538583472079e-09 1 2969277
SGTC_1171 0368-0077 21.4 µM 5.51401585428083 1.26544723923311e-05 yes 17 1.75368491774488e-08 5 3239779
SGTC_453 enantio-paf c16 10 µM 5.48511743759703 1.39559885613446e-05 yes 18 2.06597414109769e-08 7 13871343 A lipid and platelet activating factor
SGTC_2391 6285546 200 µM 5.41888679146085 1.74354199069823e-05 yes 19 2.99856377483848e-08 1 846083
SGTC_2745 rifampicin 24.3 µM 5.35636180875973 2.14641056070581e-05 yes 20 4.24571947290052e-08 1 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1719 st032227 49.2 µM 5.16702308548049 3.97455852560046e-05 yes 21 1.18925947360535e-07 4 3125804
SGTC_3071 9117417 49.47 µM 5.15902886457501 4.0775042179578e-05 yes 22 1.24117021439695e-07 4 45595590 YGL055W OLE1
SGTC_1003 4049-0218 100 µM 5.1306845687576 4.46318516264957e-05 yes 23 1.44345165873036e-07 3 295161
SGTC_2601 securinine 100 µM 5.10528151209231 4.8378953930798e-05 yes 24 1.65151212145331e-07 7 442872 A GABA receptor antagonist.
SGTC_3200 9114385 49.47 µM 5.04000494062058 5.9416127801573e-05 yes 25 2.32759914095618e-07 5 17018030 YLR208W SEC13
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 4.93855925561611 8.13862490079506e-05 yes 26 3.93509323120846e-07 5 94937 An inhibitor of serotonin biosynthesis.
SGTC_1199 1638-0010 4.46 µM 4.93273870233278 8.28544006647162e-05 yes 27 4.0542297431783e-07 1 3111136
SGTC_1289 0976-0073 69.1 µM 4.88595121882083 9.55941520503177e-05 yes 28 5.14653414715125e-07 1 3391136
SGTC_375 3970-0961 9.27 µM 4.87410799566227 9.90992732861197e-05 yes 29 5.46505940767968e-07 5 2898222
SGTC_2085 5307070 144.047 µM 4.77588687445152 0.000133187910721882 yes 30 8.94584788736558e-07 5 2840351
SGTC_2400 5203494 178.7 µM 4.75647288127525 0.000141112859784891 yes 31 9.85023448349275e-07 13 6777674
SGTC_2803 7707263 71.43 µM 4.75253743898371 0.000142772286660691 yes 32 1.00439778976384e-06 1 2199229
SGTC_212 3807-4682 38.772 µM 4.74668866917808 0.000145272298918325 yes 33 1.0338692404344e-06 19 3125501 YBL034C STU1
SGTC_900 1112-0045 141 µM 4.7359634919169 0.000149963573136647 yes 34 1.0900841752523e-06 3 56211 YIL048W NEO1
SGTC_21 0849-0113 22.993 µM 4.72221542989036 0.000156184696057742 yes 35 1.16644689193077e-06 6 1560156
SGTC_2035 5154463 94.595 µM 4.71773696645743 0.000158262866796068 yes 36 1.19241274041894e-06 5 2769623
SGTC_648 0375-0473 33.3 µM 4.64527904324225 0.000195696827582003 yes 37 1.69808546061643e-06 3 1713139
SGTC_379 3970-0972 5.9 µM 4.61806891524864 0.000211778748329244 yes 38 1.93663814909376e-06 3 2898042 YBL034C STU1
SGTC_1024 4507-0395 26 µM 4.58655523573353 0.000231943726043288 yes 39 2.25309611990559e-06 6 4201836
SGTC_1331 1472-0049 76.2 µM 4.5500995091966 0.000257501042805087 yes 40 2.68102758995559e-06 3 24051409
SGTC_3139 9095020 49.47 µM 4.47035797915236 0.000322821193888268 yes 41 3.90443917790522e-06 2 25236292
SGTC_1297 1068-0111 14.1 µM 4.44125328770353 0.000350281237940182 yes 42 4.47182232885076e-06 3 767057
SGTC_763 3453-1109 128 µM 4.41820575014674 0.000373549914673835 yes 43 4.97618282216018e-06 2 1560353
SGTC_3091 9116372 49.47 µM 4.38538628977706 0.000409169381191058 yes 44 5.78900640430268e-06 10 17169793
SGTC_2481 5478948 45.16 µM 4.38247868346755 0.000412472456583855 yes 45 5.86683248383225e-06 6 77792
SGTC_2030 5175110 200 µM 4.37739188993198 0.000418310676086336 yes 46 6.00539515877886e-06 1 2831986
SGTC_12 0849-0099 9.267 µM 4.35973295793138 0.000439178383353776 yes 47 6.5110629304995e-06 5 6071388
SGTC_3266 9136860 49.47 µM 4.35798460143428 0.00044129610319156 yes 48 6.56328084307495e-06 10 4871271 YPR165W RHO1
SGTC_1953 st076800 12.1 µM 4.34124008543433 0.000462063051835757 yes 49 7.08404037536551e-06 12 297591
SGTC_1030 k029-0042 36.7 µM 4.28365072170156 0.000540598830417139 yes 50 9.19257264906005e-06 1 6080581
SGTC_896 0964-0007 44.5 µM 4.28144367528252 0.000543841048866236 yes 51 9.28423625788535e-06 6 6756758
SGTC_832 4083-0019 164 µM 4.16958199554304 0.0007337805620111 yes 52 1.52579407054692e-05 24 1990758
SGTC_2935 9038016 29.96 µM 4.15413890051829 0.000764348686715591 yes 53 1.63257399044903e-05 7 6463195
SGTC_3081 9117243 49.47 µM 4.14314670676119 0.000786816570012617 yes 54 1.71286320937169e-05 25 45595589
SGTC_2451 5856223 45.7 µM 4.1389755385399 0.000795500372307336 yes 55 1.74430070073701e-05 9 2179896
SGTC_1291 0993-0025 5.79 µM 4.11473004284368 0.000847747307511082 yes 56 1.93816402950254e-05 1 4353356
SGTC_104 0074-0074 590.992 µM 4.10827541465242 0.000862178886666191 yes 57 1.9931228737538e-05 13 3943124
SGTC_579 4491-1009 110 µM 4.0623110364409 0.000971661851776883 yes 58 2.42946380947477e-05 6 1271041
SGTC_1884 5633444 25 µM 4.0617817335514 0.000972993815935809 yes 59 2.43497997106727e-05 14 5724239
SGTC_1452 4194-0072 190 µM 3.996410254699 0.00115099606187102 no 60 3.2155122927593e-05 3 1343545
SGTC_391 gliotoxin 8.33 µM 3.98816825869492 0.00117544117810021 no 61 3.32927161484942e-05 4 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2783 7738165 71.43 µM 3.97483971300551 0.00121598036610874 no 62 3.52133355019372e-05 4 17201110
SGTC_1022 4477-0945 21.3 µM 3.96631709685727 0.00124256868029614 no 63 3.64958701976157e-05 4 4648966
SGTC_313 3474-0040 5.03 µM 3.96267759799863 0.00125408418415455 no 64 3.70569182375253e-05 6 1043375 YIL048W NEO1
SGTC_1090 efavirenz 20.7 µM 3.91906083617277 0.00139989162002447 no 65 4.44473384072794e-05 3 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1197 1601-0112 267 µM 3.91616383123467 0.00141010395381202 no 66 4.49845603266358e-05 6 7350313
SGTC_1146 3579-1023 7 µM 3.91281331099853 0.0014219998011499 no 67 4.5613530581409e-05 5 X1146
SGTC_1518 st038567 90.8 µM 3.89911634205221 0.00147158911211825 no 68 4.827219031342e-05 3 77966
SGTC_1504 k297-0033 30 µM 3.89849546493527 0.00147387391847292 no 69 4.83961066236623e-05 1 4388117
SGTC_115 0527-0192 112.043 µM 3.88647928505515 0.0015187354507094 no 70 5.08543006981158e-05 25 4233931
SGTC_3190 9110366 49.47 µM 3.8823763705289 0.00153433634112935 no 71 5.17203048590712e-05 4 17123768
SGTC_3201 9113999 49.47 µM 3.86732445531012 0.00159282926011628 no 72 5.50179921975774e-05 7 16649224
SGTC_1249 0481-0015 10.2 µM 3.8628918807355 0.00161043791970207 no 73 5.60263047214206e-05 7 4227577
SGTC_2148 5546263 113.568 µM 3.83154349973042 0.00174012147393862 no 74 6.36709268221718e-05 4 792097
SGTC_1545 lovastatin 49.4 µM 3.81932433791629 0.00179319376498029 no 75 6.69088579631258e-05 6 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2214 7179297 48.276 µM 3.8108950560235 0.00183065891009829 no 76 6.92322715065564e-05 6 769744
SGTC_403 arphamenine a 50 µM 3.79566600723323 0.00190015584154552 no 77 7.36238124021143e-05 6 5487158 An arginine aminopeptidase inhibitor.
SGTC_3193 9111931 49.47 µM 3.74634803802664 0.00214198406902977 no 78 8.97138059225738e-05 10 17087244
SGTC_1661 st013063 9.66 µM 3.74432691810423 0.00215246509874083 no 79 9.0439007464169e-05 9 721395
SGTC_3225 9130819 49.47 µM 3.72736456700218 0.00224227727994455 no 80 9.67462375478707e-05 10 4547121
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 3.70292463306492 0.00237765760004783 no 81 0.000106564106325043 11 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1002 4049-0206 172 µM 3.68848239420136 0.002461093424733 no 82 0.00011279781649742 9 4662749
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 3.68227154691305 0.00249778219223846 no 83 0.00011558249544289 7 5393153
SGTC_1339 1486-1321 22.7 µM 3.66200196056184 0.00262098526134186 no 84 0.000125125972018973 8 3469382
SGTC_679 0422-0091 41.4 µM 3.66060795470221 0.00262965679386561 no 85 0.000125808755329957 15 627384 YHR062C RPP1
SGTC_1769 st044406 64.4 µM 3.6456747872713 0.00272418894876412 no 86 0.000133345536981469 13 670903
SGTC_883 0850-0245 24.6 µM 3.64489372096226 0.00272921676456871 no 87 0.00013375116172714 9 6823229 YPR165W RHO1
SGTC_53 0973-0023 39.979 µM 3.63087944827638 0.00282086322087836 no 88 0.000141228551318353 11 674768
SGTC_726 3448-4391 34.2 µM 3.6195049845654 0.00289727768152263 no 89 0.000147583562815059 4 1356692
SGTC_2959 9079155 11 µM 3.60863891449836 0.00297201464753648 no 90 0.000153903840541684 13 16189457
SGTC_874 0599-0792 117 µM 3.60043007782868 0.00302962233900122 no 91 0.000158845628333997 7 765305
SGTC_1805 st050013 60.3 µM 3.59872999512211 0.00304167811512191 no 92 0.000159887487594007 2 4037144
SGTC_3114 9122766 49.47 µM 3.57940121511816 0.00318181408873947 no 93 0.000172191198395269 5 17176985
SGTC_26 0302-0163 425.158 µM 3.57009840648377 0.00325130968350844 no 94 0.000178423573346306 14 3100915
SGTC_730 1436-0052 41.2 µM 3.56931601375914 0.0032572162495928 no 95 0.000178957238763048 18 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_170 4197-0004 226 µM 3.50676346664494 0.00376186121885348 no 96 0.000226796075670184 9 218692
SGTC_2146 5545642 200 µM 3.46871533837244 0.0041020811842637 no 97 0.000261476620049655 5 825326
SGTC_2576 guaiol 23.12 µM 3.44881581966751 0.004290768878859 no 98 0.00028152530377995 14 227829
SGTC_723 4182-0001 115 µM 3.41422199166772 0.00463732497730573 no 99 0.000319822176413149 9 744821 YLR208W SEC13
SGTC_1755 st041960 45.185 µM 3.39435724813506 0.00484742572777388 no 100 0.000343949462773455 13 2257073
SGTC_195 4234-0266 16.654 µM 3.38891755644044 0.00490641966303937 no 101 0.000350845520791305 23 2303354
SGTC_732 3970-1727 52.7 µM 3.38227148965218 0.004979364630875 no 102 0.00035944529615726 6 1275699
SGTC_705 1124-0212 310 µM 3.36042332621207 0.00522601769046554 no 103 0.000389115642170719 13 9554485
SGTC_1484 3473-2379 286 µM 3.35768207212756 0.00525772010906551 no 104 0.000392994799544528 5 671917
SGTC_349 k015-0014 24 µM 3.33697016336456 0.00550283308338384 no 105 0.000423485200249262 14 2196908
SGTC_130 0136-0219 337.655 µM 3.3276791003731 0.00561604843452503 no 106 0.00043786338819849 14 234244
SGTC_2571 chrysanthemic acid 100 µM 3.32429544611689 0.00565779062518974 no 107 0.000443211171513373 9 2743 An insecticide.
SGTC_1147 3809-1045 12.3 µM 3.29125783371791 0.0060800568341576 no 108 0.000498702253924159 10 325925
SGTC_3041 9091929 49.47 µM 3.26738431995979 0.00640234445728447 no 109 0.000542731083316116 10 25236887
SGTC_3093 9117344 49.47 µM 3.26417078307103 0.00644686135317963 no 110 0.000548924838534875 13 24824913
SGTC_1363 1636-0063 10.4 µM 3.22951427664531 0.00694463841664615 no 111 0.000620003450328892 15 6072185
SGTC_3311 9131146 2.8755 µM 3.22425682865324 0.00702304455001088 no 112 0.00063150035842359 28 4900406 YPR165W RHO1
SGTC_173 1273-0061 2.693 µM 3.21594717909511 0.00714856298615442 no 113 0.000650073799856889 41 2847414 YPL266W DIM1
SGTC_1934 st074720 32.6 µM 3.18239238369878 0.00767576744764343 no 114 0.00073031892827419 22 17250992
SGTC_2923 7992654 58.14 µM 3.16541826781 0.00795527273460495 no 115 0.000774300809200422 14 2985126
SGTC_1954 st077032 68.9 µM 3.15003470788276 0.00821627817367244 no 116 0.00081625533533648 12 698907
SGTC_734 2023-0417 80 µM 3.14162726640895 0.00836207842966716 no 117 0.000840058864419001 22 3935732
SGTC_849 0386-0493 241 µM 3.10763800259044 0.00897491970247688 no 118 0.000942944565383272 12 726119
SGTC_788 1182-0090 188 µM 3.10725676820077 0.00898201096216215 no 119 0.000944161531868364 21 5715185
SGTC_321 4534-3890 65.3 µM 3.10547477327467 0.00901522259775134 no 120 0.000949869123883862 14 699746
SGTC_316 k060-0003 58.6 µM 3.0954106412219 0.00920481768971718 no 121 0.000982702922295631 12 6152314
SGTC_2775 cyproheptadine 69.59 µM 3.09319264512302 0.00924706812318895 no 122 0.000990077740886129 8 2913 A selective serotonin reuptake inhibitor.
SGTC_2804 7954240 19.48 µM 3.09315919226275 0.00924770666114156 no 123 0.000990189359229761 21 828705
SGTC_2741 miltefosine 3.04 µM 3.08234349928202 0.00945618710943349 no 124 0.00102688846132272 7 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2960 9079389 5.97 µM 3.07365796251419 0.00962657135599651 no 125 0.00105725855410118 6 16457355
SGTC_1402 3909-7673 35.9 µM 3.04966827145295 0.0101111905739828 no 126 0.00114547127740288 11 5328014
SGTC_270 tamoxifen 5.46 µM 3.01842440937867 0.0107741769457575 no 127 0.00127046391052544 17 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_704 1310-0270 142 µM 3.01740304225306 0.0107964744430545 no 128 0.00127475292731057 16 5718033
SGTC_2682 pyrogallin 40.03 µM 3.01060634422592 0.010945879005751 no 129 0.00130363315132546 13 822798 An ATP competetive kinase inhibitor.
SGTC_2352 9027995 87.8 µM 3.0025830085201 0.0111245598753436 no 130 0.00133849478122774 9 2997347
SGTC_782 0083-0095 30.5 µM 2.98267661394953 0.0115788699462774 no 131 0.00142869866831873 13 3591729 An indicator and reagent.
SGTC_1449 4112-4002 201 µM 2.98044801547486 0.0116307209132972 no 132 0.0014391354301137 18 2059539
SGTC_1154 4088-0362 150 µM 2.97379569176635 0.01178669578233 no 133 0.00147070425888696 23 6618304
SGTC_1681 tripelennamine 100 µM 2.96849333614243 0.0119123152506223 no 134 0.0014963179555247 25 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1357 1503-1303 39.5 µM 2.96095748845137 0.0120928463339857 no 135 0.00153342133730351 22 292895
SGTC_1059 3448-6867 171 µM 2.95607929447677 0.0122109704112835 no 136 0.00155788488011552 18 3934407
SGTC_3166 9102297 49.47 µM 2.94746589696183 0.0124219839717174 no 137 0.00160195044790247 11 25237072
SGTC_2836 9010338 19.48 µM 2.94542693019921 0.0124723949910182 no 138 0.00161254656935011 14 2994051
SGTC_711 k292-0785 179 µM 2.9451066227945 0.0124803302881225 no 139 0.00161421693821905 17 4146315
SGTC_2539 epi(13)torulosol 80 µM 2.94259715642198 0.0125426512502328 no 140 0.00162735819840897 17 6708597
SGTC_66 0109-0187 42.4 µM 2.91700163568191 0.0131938407288249 no 141 0.00176706959727978 15 759417
SGTC_1885 st057546 99.9 µM 2.89516735540726 0.0137722264829646 no 142 0.00189478218213277 14 702008
SGTC_2557 derrustone 83.84 µM 2.89336564721132 0.0138209156513624 no 143 0.00190568655256404 11 629853 An antioxidant.
SGTC_827 3253-0474 693 µM 2.8876738703094 0.0139757061117609 no 144 0.0019405102083757 18 5402065
SGTC_2887 9044784 58.44 µM 2.86997505054601 0.0144666188194717 no 145 0.00205252093956967 38 6465546
SGTC_2634 4'-methoxyflavone 100 µM 2.85568861482775 0.0148736404980433 no 146 0.00214718036211735 22 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1971 st069429 63.5 µM 2.84625189894652 0.0151478608352545 no 147 0.00221185929374902 13 1246522 YGL099W LSG1
SGTC_2131 toluylene red 5.2905 µM 2.83905589186637 0.0153598774418642 no 148 0.00226236153610858 33 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_361 000s-0510 1.45 µM 2.83391486012235 0.0155129041778337 no 149 0.00229907904227008 14 660
SGTC_537 1334-0398 209 µM 2.83049440395526 0.0156154400416011 no 150 0.00232380621016775 23 5846986
SGTC_1735 st034310 56.75 µM 2.81932455430855 0.0159543415818169 no 151 0.00240624156445078 23 871153
SGTC_2014 4013930 200 µM 2.81890571717174 0.0159671711203019 no 152 0.0024093834986356 17 64556
SGTC_1764 st044502 93.5 µM 2.81333943148649 0.016138515400494 no 153 0.00245149329914361 18 8407
SGTC_3350 9150499 3.57 µM 2.81288632043982 0.0161525323856339 no 154 0.00245495028382956 31 4910996 YPR165W RHO1
SGTC_3356 9151811 4.48 µM 2.80766677665156 0.0163147525220046 no 155 0.00249509165237828 12 1859254 YPR165W RHO1
SGTC_3231 9132313 49.47 µM 2.80416452467083 0.0164243808254597 no 156 0.00252235777832135 17 4905967
SGTC_1902 st060212 70.5 µM 2.80343826011573 0.0164471933149196 no 157 0.00252804558578868 16 688944
SGTC_2993 9054257 71.4286 µM 2.79544464035417 0.0167000762201833 no 158 0.00259141887236484 58 6470217 YGL055W OLE1
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.79509628536474 0.0167111718683602 no 159 0.00259421298637508 24 165521
SGTC_1497 4476-2978 41.3 µM 2.78810275168272 0.0169352647226804 no 160 0.00265088625324041 21 1528379
SGTC_2584 androsterone 48.74 µM 2.78609143048096 0.0170001870257813 no 161 0.00266739110872571 54 2754130 A steroid.
SGTC_969 1313-0238 134 µM 2.76768388659775 0.0176043007162519 no 162 0.00282280930611484 52 5212874
SGTC_1961 st076550 68.7 µM 2.76697490052583 0.0176279306683877 no 163 0.00282895555219301 22 1579337
SGTC_1561 5-methoxyflavone 52.9 µM 2.76287369662517 0.0177651524408828 no 164 0.00286474663501247 11 94525
SGTC_3033 9090887 49.47 µM 2.76160297141803 0.0178078540087986 no 165 0.00287591879146108 42 19325384
SGTC_882 0843-0131 351 µM 2.76115046764393 0.0178230811143249 no 166 0.00287990666018345 31 5425421
SGTC_2575 plumbagin 510 nM 2.75625291889471 0.0179885993197422 no 167 0.00292338838196224 46 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2620 irigenin 100 µM 2.75438332958155 0.0180521289634355 no 168 0.00294014255746646 39 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1180 1193-0155 285 µM 2.75267302211767 0.018110413553352 no 169 0.00295554509080181 14 2921347
SGTC_886 0866-0150 153 µM 2.75242938829651 0.0181187292492973 no 170 0.00295774509392392 20 271463
SGTC_258 haloperidol 50.781 µM 2.75229935571215 0.0181231688461192 no 171 0.00295891988664126 40 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_786 4544-0069 423 µM 2.73365784698099 0.0187692987277874 no 172 0.00313175467328079 26 748821 YLR208W SEC13
SGTC_2952 9073731 13.78 µM 2.73253434492234 0.0188088587786914 no 173 0.00314245592369946 27 16457353
SGTC_548 1436-0017 110 µM 2.72361628833558 0.0191253996925138 no 174 0.00322857394355338 25 9677137
SGTC_2703 st077852 53.4 µM 2.71029655997241 0.0196066030834341 no 175 0.00336115365863898 24 6281836
SGTC_455 paf C-16 10 µM 2.70583675591891 0.0197700036041062 no 176 0.00340662645721336 22 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_514 4466-0038 2.65 nM 2.69479008659331 0.0201797213206633 no 177 0.00352164937725705 65 5722064
SGTC_61 0978-8327 98.565 µM 2.68673792916306 0.0204828908002711 no 178 0.0036076769785604 28 6150059 YHR072W ERG7
SGTC_2617 dihydrotanshinone i 20.83 µM 2.68446679848993 0.0205690950718427 no 179 0.0036322799162486 48 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1160 4092-0570 10.5 µM 2.67964133222267 0.0207532737152531 no 180 0.0036850541521797 32 4994975
SGTC_2976 9009005 19.48 µM 2.67835854057503 0.020802469682229 no 181 0.00369919878883769 15 2993148
SGTC_1625 st003711 30.1 µM 2.67662781620169 0.0208690006322293 no 182 0.00371835970694572 17 24207034 YER133W GLC7
SGTC_736 0958-0254 92.6 µM 2.675919612141 0.020896276663014 no 183 0.00372622589335996 20 6812352
SGTC_3087 9117406 49.47 µM 2.6724868157527 0.0210289166597342 no 184 0.00376456665312584 19 42546093
SGTC_812 4251-0442 148 µM 2.67001854493445 0.0211247280110554 no 185 0.00379235288645504 21 5723007
SGTC_752 1896-0090 130 µM 2.66576673979142 0.0212906371753125 no 186 0.00384064843581035 22 772567
SGTC_541 4513-1321 94 µM 2.65563943649799 0.0216902564149215 no 187 0.00395791003581629 30 747515
SGTC_1841 st054148 70 µM 2.65169776902715 0.021847497129996 no 188 0.00400440974136099 20 675442
SGTC_638 3970-0837 4.09 µM 2.64299129400508 0.0221982293440009 no 189 0.00410885741266514 18 4118451 YLR208W SEC13
SGTC_2570 licareol 100 µM 2.63042902313674 0.0227126536879936 no 190 0.00426385872753584 20 443158
SGTC_2582 agaric acid 100 µM 2.62668806228929 0.0228677737999474 no 191 0.00431101668079864 55 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3119 9125183 49.47 µM 2.62175168619437 0.0230738273024147 no 192 0.00437395714244362 16 22695334
SGTC_365 0121-0052 13.6 µM 2.61990671224472 0.0231512402812074 no 193 0.00439769117261256 24 3101739
SGTC_441 propafenone 146 µM 2.61614858270756 0.0233096035642926 no 194 0.00444639254350371 16 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_702 1488-0190 94 µM 2.60930943944689 0.0236001367325373 no 195 0.0045362580452578 10 949357
SGTC_2642 cholecalciferol 100 µM 2.60868650802768 0.0236267501250072 no 196 0.0045445233183969 11 9821465 A vitamin D precursor, similar to steriods.
SGTC_2143 5623677 140.463 µM 2.59861889890924 0.0240603790730623 no 197 0.00467998119302691 16 5375313
SGTC_1329 1447-1697 50.6 µM 2.59231490172093 0.0243352924507462 no 198 0.00476662330126043 14 2840515
SGTC_2249 haloperidol 116.36 µM 2.58262640131918 0.024762940604628 no 199 0.00490257184915304 74 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2422 chlorphenesin carbamate 384.24 µM 2.57649971222187 0.0250366113870687 no 200 0.00499031442880311 25 2724 A muscle relaxant with antifungal properties.
SGTC_134 0269-0018 6.916 µM 2.57330752226446 0.0251802039291887 no 201 0.00503658295755945 46 4378915
SGTC_655 k060-0012 42 µM 2.57299738606594 0.0251941913271124 no 202 0.00504109845910143 33 5994525
SGTC_1079 idarubicin 2.36 µM 2.5671914411086 0.0254572484788354 no 203 0.00512629956012992 24 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1503 4585-0012 61.3 µM 2.55886284381236 0.025838616201905 no 204 0.0052507582466142 29 2922052
SGTC_1683 st010134 710 nM 2.55323248582398 0.0260991302699145 no 205 0.00533641150338452 25 3818134
SGTC_1632 st005650 90 µM 2.5439217443821 0.0265347522754897 no 206 0.00548078196794338 23 2759605
SGTC_2774 tamoxifen 10.92 µM 2.54312564853823 0.0265722795212686 no 207 0.00549328567043099 17 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1825 st052143 62.6 µM 2.53896791507258 0.0267689925538707 no 208 0.00555900094502161 21 674173
SGTC_1042 0350-0096 82 µM 2.5247957489935 0.0274486731770866 no 209 0.0057882775423983 28 3122515
SGTC_2405 ticlatone 3.52 µM 2.52453466724213 0.027461328106295 no 210 0.00579257888779802 44 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_194 1486-1323 56.904 µM 2.52200019884368 0.0275844296871637 no 211 0.00583448211406509 33 5178754
SGTC_1608 st001473 40.5 µM 2.52104536787288 0.0276309258865069 no 212 0.00585033826390717 39 7292267
SGTC_2838 9002687 71.43 µM 2.51189604283481 0.0280797796809193 no 213 0.00600422287611488 46 6457060
SGTC_1665 st014639 11.4 µM 2.509757389553 0.0281855701098868 no 214 0.00604070668903703 26 981133 YIL048W NEO1
SGTC_1940 st075990 51.1 µM 2.50908748489388 0.0282187757178276 no 215 0.00605217510115896 30 1084979
SGTC_2638 epoxomicin 18 µM 2.47229253736037 0.0300932608439515 no 216 0.00671248047726681 12 9915668 A protesome inhibitor.
SGTC_326 k292-0812 17.5 µM 2.47213292007216 0.0301016119753531 no 217 0.00671547840887054 31 3579357
SGTC_1529 apigenin 74 µM 2.46382192303354 0.0305391028754177 no 218 0.00687321944918527 23 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_205 1486-1330 71.903 µM 2.45860686029276 0.0308163035212444 no 219 0.00697386303831497 26 4118834
SGTC_622 1348-1566 26.3 µM 2.45717698731603 0.0308926695721159 no 220 0.00700168390762163 30 7340407
SGTC_1983 st071813 46.9 µM 2.45616607832723 0.0309467542333069 no 221 0.00702141211316267 23 11838595
SGTC_2906 7926292 26.41 µM 2.45546960061808 0.0309840620746389 no 222 0.00703503262291469 23 2966319
SGTC_3058 9093861 49.47 µM 2.4440369959915 0.0316018043256966 no 223 0.00726196854577158 28 17217477
SGTC_466 geldanamycin 89.2 µM 2.4338621548887 0.0321601129741451 no 224 0.00746934146000535 10 5288382 HSP90 inhibitor.
SGTC_1675 st018485 24.5 µM 2.43115426346428 0.0323100632274398 no 225 0.00752540246171465 39 3323024
SGTC_3214 9129694 49.47 µM 2.4309696368758 0.0323203079527301 no 226 0.00752923821452531 29 17158655
SGTC_259 usnic acid 108.925 µM 2.42482737443576 0.0326626663074957 no 227 0.00765783373948494 40 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3351 9150312 21.596 µM 2.41518811812384 0.0332059656446196 no 228 0.00786354237167194 48 4904905
SGTC_1847 st056231 15 µM 2.41118199314329 0.0334339429971109 no 229 0.00795045586983066 33 5393180
SGTC_3191 9110352 49.47 µM 2.39428325697373 0.0344098286672519 no 230 0.0083264412801943 17 17122424
SGTC_2471 5466956 24.79 µM 2.39077857234171 0.0346151234705073 no 231 0.00840634461703308 55 724419
SGTC_335 4077-0256 27.6 µM 2.38364206579528 0.0350362707234553 no 232 0.00857113323354629 37 3121989
SGTC_2835 9006588 71.43 µM 2.38333185567149 0.0350546721264612 no 233 0.00857836010572945 32 2345538
SGTC_1271 0832-2808 169 µM 2.37740130823036 0.0354079949916337 no 234 0.00871755395736076 49 3663794
SGTC_1226 3909-7979 35.4 µM 2.37471163913644 0.0355691966195467 no 235 0.00878133232933958 43 6615510
SGTC_3019 9081971 49.47 µM 2.35854349568227 0.0365509345146186 no 236 0.00917340479707384 36 16451803
SGTC_1448 4255-0083 152 µM 2.3510361443163 0.0370142635999418 no 237 0.00936060761060185 38 5399660
SGTC_2019 4016004 108 µM 2.34876294629854 0.0371555011178599 no 238 0.0094179472081266 43 45595336
SGTC_119 0121-0043 24.815 µM 2.34425662059923 0.0374367883902496 no 239 0.00953252438127282 65 1092378
SGTC_1273 0849-0096 14.1 µM 2.34213150859951 0.0375700412284057 no 240 0.00958697873940415 34 5286025
SGTC_3181 9108277 49.47 µM 2.33331711045172 0.0381268788041581 no 241 0.00981575403129913 43 17097298
SGTC_3234 9132280 49.47 µM 2.32909864576849 0.0383957463577576 no 242 0.00992692021043612 33 17612295
SGTC_2724 maprotiline 69.64 µM 2.31778064142162 0.0391247523742343 no 243 0.0102306228597201 33 4011 A tricyclic antidepressant.
SGTC_1340 1486-1359 257 µM 2.31072274292956 0.0395850363736208 no 244 0.0104240870983834 33 4309068
SGTC_2073 5212005 126 µM 2.30875462142658 0.0397141706240538 no 245 0.0104786007190798 33 691789
SGTC_2103 5378138 10 µM 2.30635536922198 0.0398720556940738 no 246 0.0105453918206905 24 244142
SGTC_3271 9137798 49.47 µM 2.30448015678856 0.0399958107215769 no 247 0.0105978524934101 23 6498326
SGTC_2881 9058953 51.95 µM 2.30275883911002 0.040109684029798 no 248 0.0106462078000941 43 17122249
SGTC_1793 st048256 72.231 µM 2.2988544539968 0.0403689540517235 no 249 0.010756602725815 28 672022
SGTC_2235 salicylic acid 500 µM 2.29774921541042 0.0404425938743898 no 250 0.0107880333443057 19 338 A COX inhibitor and kinase inhibitor.
SGTC_1447 4239-0816 81.9 µM 2.29684068457153 0.0405032091009414 no 251 0.0108139298592725 43 1341554
SGTC_1912 st060209 90.8 µM 2.29492585801324 0.0406312037562401 no 252 0.010868686817363 45 688787
SGTC_1186 1319-0216 26 µM 2.2937131795393 0.0407124336817832 no 253 0.0109034896056907 38 4565136
SGTC_2002 4023503 131 µM 2.29069664192208 0.0409150648353623 no 254 0.0109904824939925 51 4736863 YCR052W RSC6
SGTC_2521 angolensin 13.4 µM 2.27856064546008 0.0417385624216104 no 255 0.0113465977995482 25 821428 A flavenoid.
SGTC_2859 9028643 45.46 µM 2.27685985014887 0.041855036320195 no 256 0.0113972980695397 21 17151580
SGTC_3334 9142812 21.919 µM 2.27072923381805 0.0422770590654561 no 257 0.0115816870877098 38 45283678
SGTC_2444 5485484 36.41 µM 2.26993717611373 0.0423318334278189 no 258 0.0116056975434846 47 6790631
SGTC_355 1311-2252 105 µM 2.26852559428637 0.0424295929963651 no 259 0.0116485954270011 40 5338538
SGTC_2947 9072639 7.68 µM 2.25705894828722 0.043230502685886 no 260 0.0120021957909356 46 16488146
SGTC_3128 9127691 49.47 µM 2.25137329593228 0.0436321318318527 no 261 0.0121809520061747 28 41316314
SGTC_1693 xanthone 101.9 µM 2.24173751932897 0.0443196652478783 no 262 0.0124891707392901 41 7020 An insecticide.
SGTC_630 4356-0227 183 µM 2.22895240245504 0.0452453600544513 no 263 0.0129085359520028 60 779312
SGTC_197 4544-0043 41.561 µM 2.22701084661594 0.0453872874584075 no 264 0.0129732744429844 68 896523
SGTC_74 000s-0487 160.283 µM 2.22688741239407 0.045396322571594 no 265 0.0129773996601078 31 677548
SGTC_2825 7998094 58.44 µM 2.20971778917352 0.0466672635132777 no 266 0.0135623771814588 50 2987815
SGTC_1044 1222-0021 1.78 µM 2.20539932118127 0.0469913808690233 no 267 0.0137130428213401 78 4306703
SGTC_3074 9116018 49.47 µM 2.18857632389133 0.048271258877826 no 268 0.0143138241130751 37 17027303
SGTC_2883 9059145 45.46 µM 2.17978044500837 0.0489514591079351 no 269 0.0146368700705726 44 16476510
SGTC_3177 9107506 49.47 µM 2.17727164079783 0.0491468664944072 no 270 0.0147301529040189 23 8897194
SGTC_2061 5245884 80.95 µM 2.16353611350585 0.0502277751844816 no 271 0.0152499846163526 32 573863
SGTC_1801 st050089 28.441 µM 2.1569284031537 0.0507544727600087 no 272 0.0155056217298866 49 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2697 mebhydrolin 72.4 µM 2.1561326527918 0.0508181972925417 no 273 0.0155366542324505 42 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2320 7373003 200 µM 2.14735256213641 0.051525553302601 no 274 0.0158826121056784 41 5415828
SGTC_1780 st038448 24.544 µM 2.13655287390204 0.0524063284547701 no 275 0.0163171880545693 48 728868 YDL195W SEC31
SGTC_1124 fisetin 1.16336 µM 2.13520581981433 0.0525170217420443 no 276 0.0163721008711101 43 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2979 9012552 45.46 µM 2.12904063325299 0.0530260122212395 no 277 0.016625449376509 30 17100905
SGTC_469 w7 172 µM 2.11971049868708 0.0538037280334564 no 278 0.017015233537578 30 45115570 A P450 inhibitor.
SGTC_2434 5670830 169.91 µM 2.11873284696604 0.0538857405939356 no 279 0.0170565253754282 41 1549830
SGTC_2211 7117706 200 µM 2.11253732949816 0.0544077692286761 no 280 0.0173201938229327 20 822771
SGTC_2496 diffractaic acid 79.83 µM 2.11043452334324 0.0545858562903543 no 281 0.0174104727160377 49 94870 An apoptosis inducer which activates caspases.
SGTC_160 3453-0671 289.699 µM 2.10913491750921 0.054696150431833 no 282 0.0174664688257711 39 5322268
SGTC_787 4152-0075 138 µM 2.10163842169968 0.0553358016474885 no 283 0.017792480749056 45 9566539
SGTC_3014 9081533 49.47 µM 2.1011493579499 0.0553777362476482 no 284 0.0178139286377079 49 21367265
SGTC_288 1315-0019 35.1 µM 2.10102886880541 0.0553880713989254 no 285 0.0178192160734911 67 6811474
SGTC_1491 4138-0063 26.5 µM 2.09520417871191 0.055889512579841 no 286 0.0180764229882147 32 23883227
SGTC_2130 NSC 7 2.4545 µM 2.08950502746678 0.0563836059679716 no 287 0.0183311429325581 44 21448
SGTC_2882 9058044 58.44 µM 2.08690753215718 0.0566099374988683 no 288 0.0184482469520438 44 18076804
SGTC_1900 st060200 72.8 µM 2.08457845534344 0.0568134886319645 no 289 0.0185537909129132 49 688945
SGTC_1647 st011722 22.4 µM 2.0828351915292 0.0569662191237339 no 290 0.0186331243122846 45 2854783
SGTC_47 0149-0135 24.25 µM 2.07543278792604 0.0576183608860135 no 291 0.0189732210219215 48 5239155
SGTC_2771 fluoxetine 41.05 µM 2.06952264138367 0.0581432403059586 no 292 0.0192485344616613 33 3386 A selective serotonin reuptake inhibitor.
SGTC_2367 9070478 135.38 µM 2.06800529963913 0.058278599503457 no 293 0.0193197623782943 55 572802
SGTC_2931 9014674 55.67 µM 2.06620153325391 0.0584398319993622 no 294 0.0194047270750025 35 2996810
SGTC_3027 9089541 49.47 µM 2.06575924143415 0.0584794203777531 no 295 0.0194256092077925 53 9943819
SGTC_2606 farnesol 9.78 µM 2.05175239660098 0.059744063146744 no 296 0.020096865879079 67 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.04708113566735 0.0601705514590665 no 297 0.0203250594255937 34 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3052 9092717 49.47 µM 2.04655101618137 0.060219101831779 no 298 0.0203510942724976 47 25237534
SGTC_562 3772-2733 112 µM 2.04003946897648 0.060817959004053 no 299 0.0206731973867071 43 2876874 YIL048W NEO1
SGTC_1700 st030840 7.9285 µM 2.03507356130145 0.0612777881874093 no 300 0.0209217358967232 63 5499307
SGTC_3182 9108849 49.47 µM 2.03205023268839 0.0615590675170148 no 301 0.0210742854312112 39 17133045
SGTC_1103 duloxetine 36.1 µM 2.02632684642937 0.0620943102954876 no 302 0.02136565095369 65 60835 A selective serotonin reuptake inhibitor.
SGTC_3157 9099274 49.47 µM 2.02381779154039 0.0623300952183457 no 303 0.0214944514612811 44 17217662
SGTC_2909 7941780 10.49 µM 2.02255022609526 0.0624494780878388 no 304 0.021559770155311 47 1243215
SGTC_287 k060-0039 29.6 µM 2.02159686388905 0.0625393858299355 no 305 0.0216090081597868 59 5861974
SGTC_772 k072-0172 35.3 µM 2.02095144315321 0.062600310113879 no 306 0.0216423959184687 34 5861980
SGTC_1442 4112-3290 3 µM 2.01219893685035 0.0634310751119975 no 307 0.0220994852655025 32 704353
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.0113127804235 0.0635156629192539 no 308 0.0221462146992051 59 368090
SGTC_2844 9010103 25.97 µM 2.00986845923805 0.0636537182907867 no 309 0.0222225563852669 53 2480525
SGTC_2999 9069765 71.4286 µM 2.00836703122053 0.063797479597899 no 310 0.0223021518122156 43 2097066
SGTC_1707 st032323 6.317 µM 2.00663550071133 0.0639635865890558 no 311 0.0223942441884403 81 3132057 YMR211W DML1
SGTC_1860 st056228 74.6 µM 2.00530782235176 0.0640911793928065 no 312 0.0224650745423979 60 688679
SGTC_1193 1488-0126 41.5 µM 2.00406717648692 0.0642105869415955 no 313 0.0225314324581732 45 1384710
SGTC_999 SEC7.066 22.7 µM 2.0020333112728 0.0644067129082661 no 314 0.0226405744982879 68 740511 YDR170C SEC7
SGTC_2611 pyromycin 23.93 µM 1.99954669931562 0.0646471293733371 no 315 0.02277461718691 50 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_767 0929-0023 86 µM 1.99464887435814 0.0651227102888 no 316 0.0230405945404285 71 1204563
SGTC_1799 st045822 46.1415 µM 1.99389933497786 0.0651957298163434 no 317 0.0230815283267081 45 3674992
SGTC_2460 5552655 174.22 µM 1.9891397867221 0.0656608846135856 no 318 0.0233428879234444 66 5401989
SGTC_84 0443-0269 128.823 µM 1.98478060382121 0.0660891649930916 no 319 0.0235844431921582 41 6150058
SGTC_1060 3448-7350 82 µM 1.9847576853662 0.0660914223873728 no 320 0.0235857187067134 64 570178
SGTC_1225 1216-0074 20.6 µM 1.98355666456797 0.0662098026877238 no 321 0.0236526421236732 39 4241466
SGTC_94 0334-0113 514.748 µM 1.97799926297364 0.0667597150803751 no 322 0.0239643949021025 44 6795178
SGTC_841 0251-0215 91.2 µM 1.97499945021292 0.0670580157758875 no 323 0.0241341052004347 52 3888614
SGTC_2050 5263056 171 µM 1.97429132432759 0.0671285818148601 no 324 0.024174313410557 82 763468 YGL055W OLE1
SGTC_2040 5100729 123 µM 1.97023552091109 0.06753385685867 no 325 0.0244056921702549 59 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1467 k284-1082 293 µM 1.95860505790842 0.0687065147123233 no 326 0.0250795284002202 49 3334705
SGTC_253 dyclonine 31.25 µM 1.9578497161286 0.068783212748033 no 327 0.0251238248538289 57 3180 An oral anasthetic.
SGTC_41 0478-0632 82.643 µM 1.95218529832779 0.0693604878709701 no 328 0.0254581045010459 72 3750424
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.94760758888252 0.0698297345324255 no 329 0.0257309675109212 51 688664
SGTC_1259 0671-0132 43 µM 1.93718525188477 0.0709072061925628 no 330 0.0263613511974178 56 X1259
SGTC_1573 oleylamine 1.06 µM 1.93147827500361 0.0715025860171418 no 331 0.0267119667114313 51 5356789 An amine of the fatty acid oleic acid.
SGTC_1242 0402-0103 60.1 µM 1.92305195848101 0.072388664494005 no 332 0.02723676243491 54 432868
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.91724701428116 0.0730039674051901 no 333 0.0276032789185285 55 15053
SGTC_1748 st037455 53.6035 µM 1.91279062176358 0.0734790386868969 no 334 0.0278874311163353 72 580690
SGTC_2782 7736369 71.43 µM 1.91164317721707 0.0736017432896037 no 335 0.0279609886221588 66 2950836 YOL077C BRX1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.90910571555932 0.0738736487736328 no 336 0.0281242277924705 49 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1037 k284-1091 78.7 µM 1.90517137569428 0.0742967557485519 no 337 0.0283788988745862 47 3334711
SGTC_710 3448-4187 58 µM 1.90069639027799 0.0747802515090258 no 338 0.0286708958208288 66 3946412
SGTC_1078 idebenone 36.1 µM 1.90003155030772 0.0748522879078878 no 339 0.028714489678903 69 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_954 1189-0853 2.85 µM 1.89971081054437 0.0748870594629993 no 340 0.0287355404315594 51 2828194
SGTC_3016 9080866 49.47 µM 1.89920557369354 0.0749418574286297 no 341 0.0287687261001446 54 17066299
SGTC_1680 diphenhydramine 100 µM 1.89336087086902 0.0755779989855445 no 342 0.0291549476476335 73 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_479 n-linoleoylglycine 10 µM 1.88691586640525 0.0762842386441354 no 343 0.029585821344751 57 6433346 An anti-infammatory.
SGTC_583 1488-1091 88.9 µM 1.88690729976681 0.0762851807018545 no 344 0.029586397556085 82 4303273
SGTC_916 4466-0038 42 nM 1.88490471585304 0.0765056442527392 no 345 0.029721351658892 93 5722064 YGL116W CDC20
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.8826836136466 0.0767507309041701 no 346 0.0298716287109462 44 2374 Ca(2+)-ATPase inhibitor.
SGTC_2395 5646831 180.19 µM 1.88124084620907 0.0769102520694199 no 347 0.0299695818459114 62 6808628
SGTC_1835 st008666 49.2 µM 1.88056868099407 0.0769846567616205 no 348 0.0300153077202446 36 690455
SGTC_2802 7925815 54.55 µM 1.87476319881045 0.0776295676495379 no 349 0.030412654053688 72 1262923
SGTC_1901 st060216 58.6 µM 1.86767330985667 0.0784227121994839 no 350 0.0309038105394446 61 688792
SGTC_1361 1608-0041 5.61 µM 1.86693481794457 0.0785056791838592 no 351 0.0309553454493309 61 X1361
SGTC_3229 9132204 49.47 µM 1.86344894714974 0.0788982031031223 no 352 0.0311995644835651 31 17682924
SGTC_3112 9123419 49.47 µM 1.86212821899969 0.0790473104679406 no 353 0.0312925096290844 63 17015854
SGTC_1137 ixabepilone 100 µM 1.85484330062166 0.0798735995235301 no 354 0.0318093033217804 64 154225 A novel microtubule stabilizer.
SGTC_405 ebelactone b 50 µM 1.85473284388238 0.0798861781165112 no 355 0.0318171930841476 38 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1391 3442-0225 151 µM 1.85057313944181 0.0803609681696953 no 356 0.0321154934653527 51 5227075
SGTC_1202 1988-0068 29.6 µM 1.84730366377517 0.0807356413874871 no 357 0.0323515711308512 59 2850480
SGTC_2158 5657123 3.6195 µM 1.84306667732593 0.0812231492614885 no 358 0.0326596379365692 72 2858827
SGTC_721 1187-1332 279 µM 1.83955796313805 0.0816285405770879 no 359 0.0329165803747293 58 25730
SGTC_1106 tegaserod maleate 11.7 µM 1.83619921383685 0.0820180325009774 no 360 0.0331640994580458 66 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2380 9035439 200 µM 1.83599487008482 0.0820417740024843 no 361 0.0331792076775211 53 6462575
SGTC_25 0118-0223 35.662 µM 1.83528394280134 0.0821244128152688 no 362 0.0332318144913825 45 5333628
SGTC_304 1310-0298 97 µM 1.83385389383441 0.0822908328690197 no 363 0.0333378425831442 67 1550234
SGTC_2475 5812728 15.03 µM 1.82955528796818 0.0827926065124808 no 364 0.0336582324082519 80 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2653 dihydrofissinolide 100 µM 1.82550371387347 0.0832676485228225 no 365 0.0339625256290919 48 6857746
SGTC_2674 ligustilide 100 µM 1.82362542443538 0.0834885695786896 no 366 0.0341043600949108 62 5319022 A signalling regulator.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.82140265957265 0.0837505759609497 no 367 0.0342728355987952 69 688801
SGTC_3323 9138564 53.9225 µM 1.819053760401 0.0840281210195362 no 368 0.0344516142920062 68 43912313 YNL103W MET4
SGTC_2848 9016370 25.97 µM 1.81696986206556 0.0842749312860341 no 369 0.0346108640905331 55 7894410
SGTC_2168 5727979 200 µM 1.81065286284188 0.0850264207498568 no 370 0.035097301876651 66 695210
SGTC_1560 lithocholic acid 53.1 µM 1.80987675591209 0.0851190941547092 no 371 0.0351574507367171 41 9903 A bile acid which acts as a detergent.
SGTC_1879 gemcitabine 100 µM 1.80152167840361 0.0861215559345599 no 372 0.0358103467867819 58 60750 A nucleoside analog which inhibits DNA replication.
SGTC_650 1328-0195 38 µM 1.79900565836325 0.0864251574808343 no 373 0.0360088928248369 63 2780821
SGTC_1588 farnesol 29.9 µM 1.79710342144613 0.0866552261305993 no 374 0.0361596013292357 62 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1618 st003135 44.5 µM 1.79346181355335 0.087096941835407 no 375 0.0364495556652841 63 1270615
SGTC_1570 verbenone 133 µM 1.79312648463098 0.0871377005872336 no 376 0.0364763508295266 61 29025 A natural terpanoid with antifungal properties.
SGTC_3098 9119039 49.47 µM 1.78917738777644 0.0876187797989226 no 377 0.0367931260566791 64 17161528
SGTC_3270 9137563 49.47 µM 1.78670490036708 0.087920985516719 no 378 0.0369925983268876 51 17015724
SGTC_2880 9042983 58.44 µM 1.78036109196251 0.0886999276651718 no 379 0.0375084424905911 82 6464714
SGTC_207 4185-0010 4.486 µM 1.77977056103244 0.0887726983099591 no 380 0.037556758663077 92 3761753
SGTC_336 4111-0029 111 µM 1.77910966834773 0.088854192284823 no 381 0.0376108919574353 53 3131175
SGTC_1999 st074831 12.5 µM 1.77194867893151 0.08974078060545 no 382 0.0382015383865845 81 17112523
SGTC_2795 7780010 54.55 µM 1.7644190251096 0.0906800878995754 no 383 0.0388307286958962 76 953673
SGTC_1173 0443-0020 122 µM 1.76431224320563 0.090693460976104 no 384 0.0388397119024513 72 5331295
SGTC_1637 st007924 17.4 µM 1.75621211275338 0.0917121711550975 no 385 0.0395260986095847 54 683336
SGTC_1982 st072467 71.9 µM 1.75314739760075 0.0920998064854266 no 386 0.039788354751557 85 3163533
SGTC_1809 st050081 57.6 µM 1.75092363247904 0.0923818341498123 no 387 0.0399795327091289 64 5036894
SGTC_611 3453-1652 23.7 µM 1.74863409511495 0.0926728705295932 no 388 0.040177144397006 97 1560575
SGTC_421 streptovitacin 30 mM 1.74630726535746 0.0929693415963069 no 389 0.0403787870410669 60 91467 include heat shock
SGTC_1641 st009299 47.1 µM 1.74525741218731 0.0931033370667215 no 390 0.0404700357796911 80 4046054
SGTC_1889 st059080 5.18 µM 1.73604312868358 0.0942855085980573 no 391 0.0412781044795496 61 176925 Isolated from Daphnopsis sellowiana.
SGTC_687 k029-0044 34.9 µM 1.73463752470464 0.0944668133149708 no 392 0.0414025142820327 44 5829338
SGTC_2008 4012253 172 µM 1.73460138308897 0.094471478502916 no 393 0.0414057171739696 74 603940
SGTC_2549 cedrol 20.94 µM 1.73359357883266 0.094601635081182 no 394 0.041495110296909 92 6708665 A sedative which affects the nervous system.
SGTC_3054 9094397 49.47 µM 1.72729871687044 0.0954176006390889 no 395 0.0420570147608679 81 2598354
SGTC_2912 7964298 10.93 µM 1.72290617782459 0.095990040397037 no 396 0.0424527464930325 102 2975850
SGTC_1053 3366-3204 134 µM 1.72109999452041 0.0962261551763373 no 397 0.042616340148998 83 3632071 YPR165W RHO1
SGTC_2619 obliquin 87.91 µM 1.71699457289224 0.0967644272319304 no 398 0.0429900817998143 90 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.71479593508015 0.0970536037217216 no 399 0.0431913235390819 55 641818 YHR062C RPP1
SGTC_1967 st070177 51.4 µM 1.70890090244647 0.0978320791265618 no 400 0.043734653667427 79 5729214
SGTC_2441 5730946 39.09 µM 1.70793727039575 0.0979597667111478 no 401 0.0438239913329422 69 1774275
SGTC_769 0302-0231 76 µM 1.70499435036266 0.0983504789498946 no 402 0.0440977390527821 107 571869 YER009W NTF2
SGTC_1839 st053978 48 µM 1.70304547185249 0.0986098461744871 no 403 0.0442797795550874 59 3788398
SGTC_2339 9000433 200 µM 1.70069445533421 0.0989233979754446 no 404 0.0445001884185071 66 2988954
SGTC_615 k087-0205 167 µM 1.69339384132881 0.0999017191389843 no 405 0.0451902631891747 77 9642773
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.68765732804772 0.100675386040625 no 406 0.0457385137994328 81 23847180
SGTC_2113 5491891 107.031 µM 1.68521859137396 0.101005611870908 no 407 0.0459732027107041 88 789979
SGTC_90 0870-0863 4.608 µM 1.68515604003955 0.101014092230698 no 408 0.045979234965635 86 1738164
SGTC_1645 Cervolide 78 µM 1.6809022947553 0.101592009560781 no 409 0.0463909470894361 79 23173 A fragrance.
SGTC_1804 st050076 49.1 µM 1.67649256282752 0.102193657227631 no 410 0.0468208758794497 91 3895976
SGTC_2456 5770359 74.46 µM 1.67625924969507 0.102225561658437 no 411 0.046843711573693 76 3118787
SGTC_820 1582-0060 59.9 µM 1.66763399726012 0.103410112397817 no 412 0.0476942025360908 82 3848840
SGTC_108 0509-0257 621.132 µM 1.66428858354047 0.103872226984327 no 413 0.048027386383542 88 536624
SGTC_2015 5119600 184 µM 1.66333789440992 0.104003822137224 no 414 0.0481224086652597 98 2828786
SGTC_853 0419-0306 21 µM 1.65958073327667 0.104525074347362 no 415 0.0484994134616663 102 762713
SGTC_3176 9106582 49.47 µM 1.6552670557218 0.10512586606541 no 416 0.048935169228494 31 17018027
SGTC_606 k015-0008 38.6 µM 1.6543526291424 0.105253544136313 no 417 0.0490279427156013 80 1970475
SGTC_105 0111-0055 734.78 µM 1.64694508410649 0.106291970327113 no 418 0.0497846669844392 64 5179370
SGTC_1301 naphtanilide LB 4.81 µM 1.63972753497465 0.107310859335748 no 419 0.0505309155657495 94 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2347 9049783 174.81 µM 1.63567855644033 0.107885520359302 no 420 0.0509534398393203 78 6467988 YPL169C MEX67
SGTC_2290 7904846 200 µM 1.63172247995199 0.108449133432313 no 421 0.0513689810907932 88 2962154
SGTC_109 0132-0036 33.701 µM 1.63110192424598 0.108537734433197 no 422 0.0514344073688876 77 67274 A color developer.
SGTC_1524 corynanthine 62.1 µM 1.62932290256158 0.108792026170319 no 423 0.0516223401413636 80 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_616 4092-0450 108 µM 1.62875375641924 0.108873469778022 no 424 0.051682578888864 70 787165
SGTC_2028 5153890 36.43 µM 1.62599826378512 0.109268394791049 no 425 0.0519750123534548 103 2830968 YPR165W RHO1
SGTC_868 0527-0199 213 µM 1.6240884982558 0.109542710974309 no 426 0.0521784611735653 80 2849450
SGTC_2627 acetyl isogambogic acid 100 µM 1.62237820508898 0.10978879465182 no 427 0.0523611964422837 88 6857789 A caspase activator and apoptosis inducer.
SGTC_3346 9158254 43.5805 µM 1.62195747593739 0.109849391575376 no 428 0.0524062267833587 96 17639500
SGTC_3206 9114350 49.47 µM 1.62168927314759 0.1098880329056 no 429 0.0524349483794064 68 17087243
SGTC_1182 1222-0449 220 µM 1.62079613531709 0.110016782110978 no 430 0.0525306838125614 65 658318
SGTC_1016 4226-1401 38 µM 1.61542792225058 0.110792910969237 no 431 0.0531090287746782 99 2901613
SGTC_1413 3910-0535 34.4 µM 1.61126615241071 0.111397307875435 no 432 0.0535608623867577 87 2876951
SGTC_3236 9132701 49.47 µM 1.60536956434517 0.112257680292696 no 433 0.0542062491482668 85 24282524
SGTC_1048 3161-0300 24.5 µM 1.60088541585487 0.112915134762293 no 434 0.0547011501799851 60 2165101
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.60056474510113 0.112962255780106 no 435 0.0547366779977739 82 803109
SGTC_1314 1222-0010 41.1 µM 1.60022088830616 0.113012799467279 no 436 0.0547747949135653 74 3526027
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.60010985458528 0.113029123817886 no 437 0.0547871076081035 84 688751
SGTC_3044 9093193 49.47 µM 1.5996149032338 0.113101912807031 no 438 0.0548420201155494 86 25236277
SGTC_833 3852-0053 558 µM 1.5984912321633 0.113267287305629 no 439 0.0549668475847846 87 3123681
SGTC_1877 wortmannin 25 µM 1.59756091016072 0.113404336435238 no 440 0.0550703659073155 82 312145 A covalent inhibitor of PI 3-kinase.
SGTC_351 caspofungin 25 nM 1.5953971372271 0.113723547031011 no 441 0.0553117278968488 114 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2644 guaiazulene 100 µM 1.5949428258283 0.113790650592539 no 442 0.055362510848887 55 3515 A coloring agent.
SGTC_989 1501-0895 10.3 µM 1.59396275842892 0.113935506452569 no 443 0.0554721882148738 72 2830112
SGTC_3228 9131799 49.47 µM 1.59334845312571 0.114026368927627 no 444 0.055541021294449 90 17015818
SGTC_964 1287-0107 19.4 µM 1.59305239400796 0.114070177740016 no 445 0.0555742188695489 96 51516812 YPR165W RHO1
SGTC_1302 1159-0335 255 µM 1.59126711275806 0.114334605653956 no 446 0.0557747373822711 79 649284
SGTC_1650 st011916 45.8 µM 1.59080540268715 0.114403063071966 no 447 0.0558266883546865 76 242528
SGTC_2210 7115885 190.385 µM 1.59003351016777 0.114517576180526 no 448 0.055913625883212 84 2927039
SGTC_302 1094-0063 18.9 µM 1.58934834287558 0.114619291613205 no 449 0.0559908850757805 115 5440289
SGTC_2954 9074818 52.69 µM 1.58880156923415 0.114700508147961 no 450 0.0560525994440179 99 16648742
SGTC_489 paxilline 115 µM 1.58077224248566 0.115897884648918 no 451 0.0569650616988944 81 105008 A toxic potassium channel blocker.
SGTC_69 0096-0274 206.684 µM 1.58018411622204 0.115985936770802 no 452 0.0570323541127902 154 6741392
SGTC_2915 7971052 15.16 µM 1.57901931074126 0.116160467354647 no 453 0.0571658138912456 59 5741558
SGTC_2896 9052656 71.43 µM 1.57487183621338 0.116783424281249 no 454 0.0576430153475707 124 6469436
SGTC_3282 9108498 15.4605 µM 1.57470700449243 0.116808231094159 no 455 0.0576620451384004 92 16459645
SGTC_3285 9112818 20.8695 µM 1.57237405979795 0.117159734789096 no 456 0.0579319132770579 112 17017947 YPR165W RHO1
SGTC_2760 etidronate 98.04 µM 1.56975185622728 0.117555714714171 no 457 0.0582364259725499 82 3305 A chelator and antioxidant.
SGTC_582 0987-0078 156 µM 1.5689053348425 0.11768375029552 no 458 0.0583349993139577 96 1625765
SGTC_174 3553-0389 74.3 µM 1.56528185889039 0.118232913050385 no 459 0.0587584174298167 86 738071
SGTC_2200 6600604 21.907 µM 1.55679581107381 0.119526116401663 no 460 0.0597594860378117 98 2904777
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.54870776906285 0.120767924243086 no 461 0.0607259927147175 71 1241132 A phosphatase inhibitor.
SGTC_619 1652-1634 108 µM 1.54743974608248 0.120963432259675 no 462 0.0608786216382436 88 5400454
SGTC_1465 k213-0056 144 µM 1.54364990004177 0.121549090485016 no 463 0.0613365847196464 115 24048857 YMR208W ERG12
SGTC_2268 7933382 153.85 µM 1.54024993861138 0.122076192038275 no 464 0.0617497206714886 93 935025 YOR257W CDC31
SGTC_274 sirtinol 40.1 µM 1.5367970789209 0.122613135174546 no 465 0.0621715044944221 99 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_594 1487-1584 10.8 µM 1.53662966156709 0.122639211759253 no 466 0.0621920123353366 100 5013332
SGTC_3171 9103192 49.47 µM 1.53644809233229 0.122667497009362 no 467 0.0622142596797306 73 13018434
SGTC_2319 6033012 152.6 µM 1.53324238150368 0.123167643373646 no 468 0.0626080727000078 87 847246
SGTC_544 k015-0020 52.4 µM 1.53118932373168 0.123488705678141 no 469 0.0628613043166888 104 3008304
SGTC_2526 patulin 37.61 µM 1.52967104730996 0.123726514280036 no 470 0.0630490868126548 113 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3026 9090633 49.47 µM 1.52862238652458 0.123890953781177 no 471 0.0631790415055827 81 25236842
SGTC_2474 5321570 43.32 µM 1.52494463622831 0.124468867034565 no 472 0.063636453627643 88 2841384
SGTC_2241 6772625 37.8075 µM 1.51880344466467 0.125438076199392 no 473 0.0644059892965071 98 2285411
SGTC_501 nsc-95397 161 µM 1.51560257358772 0.125945323904557 no 474 0.0648099379604413 98 262093
SGTC_589 1227-0070 34.1 µM 1.51534625999328 0.125986004140428 no 475 0.0648423695128744 94 2841384
SGTC_1238 0333-0287 48.8 µM 1.51524602331884 0.126001915470672 no 476 0.0648550559617096 82 7226
SGTC_2911 7942208 15.64 µM 1.51314382807466 0.126335935785583 no 477 0.0651215644250349 71 1243384
SGTC_457 grayanotoxin iii 135 µM 1.51221910174724 0.126483061889547 no 478 0.0652390665874606 115 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_631 k072-0230 41.5 µM 1.5109082439876 0.126691826862878 no 479 0.0654059150800272 105 5773147
SGTC_1443 4112-3303 14 µM 1.50882864286487 0.127023512672519 no 480 0.0656712894976711 110 704433
SGTC_1846 st056244 14.8 µM 1.49833493030084 0.128706423257804 no 481 0.0670231265289086 77 5393182
SGTC_189 3970-0742 2.116 µM 1.49247967042616 0.129652145326628 no 482 0.0677867214159042 91 2891807
SGTC_3265 9137266 49.47 µM 1.49218708801945 0.129699528199176 no 483 0.0678250531597195 61 17224265
SGTC_3294 9122953 26.2835 µM 1.49216827047393 0.12970257605654 no 484 0.067827519052834 94 16459826
SGTC_745 0469-0705 296 µM 1.48676701302168 0.13057946301238 no 485 0.0685381783217999 143 3486736
SGTC_252 miconazole 1.30953 nM 1.48348013976362 0.131115084390488 no 486 0.0689734446120495 123 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_952 1185-0122 232 µM 1.48288102597891 0.131212877905611 no 487 0.0690530117129298 87 678600
SGTC_2680 butyl paraben 22.24 µM 1.48124013128428 0.131480979511292 no 488 0.0692712978460099 107 7184 An antifungal and steroid mimetic.
SGTC_973 1325-0077 65.9 µM 1.48119937762777 0.131487642956613 no 489 0.069276726010537 87 2835149
SGTC_867 0518-0118 155 µM 1.47890832945025 0.131862616807838 no 490 0.0695824084347773 108 6848158
SGTC_27 0485-0001 32.618 µM 1.47583081017643 0.132367471702229 no 491 0.0699946587109866 87 2054479
SGTC_1352 1496-0991 99 µM 1.47376421998847 0.132707234372212 no 492 0.0702725425264922 98 3000039
SGTC_210 3551-0445 56.827 µM 1.46642196363843 0.133919211135708 no 493 0.071266683185516 92 2865180 YOR207C RET1
SGTC_3260 9137109 49.47 µM 1.46585159267405 0.134013678924498 no 494 0.0713443610179715 79 17478346
SGTC_31 0508-1974 57.237 µM 1.46570157227151 0.134038533683031 no 495 0.0713648028271849 84 6810525
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.46218487541428 0.134622072868153 no 496 0.0718452775445708 95 115019
SGTC_1064 honokiol 6.76 µM 1.46198433846025 0.134655401213359 no 497 0.0718727508359167 114 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1867 st057372 64 µM 1.46039419608977 0.1349198762396 no 498 0.0720908834897116 84 688837
SGTC_143 4032-1194 15.74 µM 1.4588558685666 0.135176072225978 no 499 0.0723023909015665 130 1806963
SGTC_2469 5655019 90.81 µM 1.45471502011553 0.135867353553121 no 500 0.0728740863054382 87 2788239
SGTC_2673 kobusone 100 µM 1.45171518238005 0.136369661902509 no 501 0.0732904080128244 92 6710676 An epoxy ketone and protein crosslinker.
SGTC_708 3448-5400 146 µM 1.45158841836166 0.136390915866336 no 502 0.0733080404852777 145 3462195
SGTC_2102 5377816 72.7585 µM 1.45125873085302 0.136446203727285 no 503 0.0733539141655319 113 1379702
SGTC_2322 7413319 38.22 µM 1.44847379855298 0.136913842356091 no 504 0.0737422942943542 128 1840400
SGTC_554 4483-2211 187 µM 1.44527243153859 0.137452759476111 no 505 0.0741906891496988 82 747107
SGTC_2819 7996655 46.38 µM 1.43937920115408 0.138448606763057 no 506 0.0750215569760846 74 6456960
SGTC_939 1165-0479 45.3 µM 1.43872925843204 0.138558735375449 no 507 0.0751136231119199 97 1377347
SGTC_2435 5706476 10.6 µM 1.43433323427066 0.139305180364688 no 508 0.0757385952840096 90 5725375
SGTC_3131 9127911 49.47 µM 1.43083892226927 0.139900462976322 no 509 0.0762381925717519 98 45595681
SGTC_397 arbidol 50 µM 1.42605650346849 0.140717982977931 no 510 0.0769260164036793 97 131410 A RNA synthesis inhibitor.
SGTC_520 3584-0023 682 µM 1.42600449082047 0.140726891949055 no 511 0.0769335228855576 118 1340790
SGTC_1136 pergolide 1.05886 µM 1.42518992255674 0.140866464969897 no 512 0.0770511542886128 136 47811 A dopamine receptor agonist.
SGTC_899 1083-0020 478 µM 1.42516961818017 0.140869945242992 no 513 0.0770540881787522 109 767123
SGTC_2223 6903751 107.57 µM 1.42405293296099 0.141061440578206 no 514 0.0772155748853614 96 5598863
SGTC_686 1319-0111 510 µM 1.42356832415176 0.141144598871684 no 515 0.0772857353598094 119 4562600
SGTC_1382 3002-2117 298 µM 1.42128614724581 0.14153666452451 no 516 0.0776167945289656 106 1497314
SGTC_1779 st039427 55 µM 1.41771009503532 0.142152493739357 no 517 0.0781377107819947 102 1124498
SGTC_1094 duloxetine 25.4 µM 1.41638472084059 0.142381195331848 no 518 0.0783314474725703 96 60834 A selective serotonin reuptake inhibitor.
SGTC_152 4469-0003 551.229 µM 1.41515760445246 0.142593163725999 no 519 0.0785111458623938 146 697280
SGTC_2271 7849410 118.62 µM 1.41475269189223 0.14266315390364 no 520 0.0785705096011375 107 972430
SGTC_2873 9040596 71.43 µM 1.41442048786212 0.142720593567851 no 521 0.0786192390326121 128 6463863
SGTC_2523 spermine 47.74 µM 1.41153841538651 0.143219573853659 no 522 0.0790429583591198 81 1103 A DNA binding polyamine.
SGTC_3126 9127922 49.47 µM 1.41065376286173 0.143372971983416 no 523 0.0791733653622826 158 45595682
SGTC_920 mycophenolic acid 780.421 nM 1.40326032829449 0.144659325754802 no 524 0.0802696118047122 94 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_575 k072-0246 11.9 µM 1.40100015483234 0.145054110956806 no 525 0.0806070134031896 112 6796779
SGTC_146 3448-8650 53.125 µM 1.39911604296856 0.145383763092288 no 526 0.080889093792197 126 2891488 YIL048W NEO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.39798938726035 0.145581128102053 no 527 0.0810581270761844 119 390807
SGTC_850 0388-0143 75.9 µM 1.3972352947912 0.145713328924916 no 528 0.0811714131629004 105 67273
SGTC_2541 muurolladie-3-one 83.07 µM 1.39356707633949 0.14635755940511 no 529 0.0817241882204162 156 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_341 1486-1430 230 µM 1.39194912553808 0.146642318713251 no 530 0.0819689021014427 152 2054753 YPL210C SRP72
SGTC_1000 4048-0884 8.67 µM 1.38646117548308 0.147610965626805 no 531 0.082803063767034 104 13040088
SGTC_2342 7990637 118.86 µM 1.38640779321797 0.147620408826252 no 532 0.0828112090562834 128 2033102 YER133W GLC7
SGTC_230 MPP+ 141.667 µM 1.3840340207766 0.14804073276453 no 533 0.0831740189244853 108 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_359 0081-0058 15.9 µM 1.38313236089962 0.148200599404194 no 534 0.0833121423464085 125 3494159
SGTC_2480 5767542 37.17 µM 1.38210101909982 0.148383600557096 no 535 0.0834703428127531 110 2867358
SGTC_2274 7947094 46.08 µM 1.38185849915729 0.148426655203409 no 536 0.0835075764055475 111 2971028
SGTC_2709 st078560 56 µM 1.37903537203076 0.148928460588113 no 537 0.0839419241015466 129 17250903
SGTC_3174 9107204 49.47 µM 1.37727637006774 0.149241692285627 no 538 0.0842134090341566 104 3938802
SGTC_1527 coumarin 137 µM 1.37580681242894 0.149503718657489 no 539 0.0844407258887902 123 323 A hepatotoxic, DNA x-linker.
SGTC_1648 st011736 69.8 µM 1.37571963571221 0.149519272159298 no 540 0.0844542251711839 107 2855514
SGTC_2142 5622915 118.518 µM 1.37525321397065 0.149602506432435 no 541 0.0845264779127673 81 5322196
SGTC_2780 5215298 71.43 µM 1.37279709336465 0.150041318079322 no 542 0.0849077173123917 137 2834131
SGTC_2785 7756463 72.73 µM 1.37231308991082 0.150127891474357 no 543 0.0849829962045077 153 2201551
SGTC_1135 dihydrocapsaicin 536.708 nM 1.37065098505519 0.150425444608752 no 544 0.0852418905748734 117 107982 A Capsaicinoid.
SGTC_3076 9116187 49.47 µM 1.36994313941066 0.1505522836811 no 545 0.0853523259511136 90 27241210
SGTC_1370 2001-0092 44.6 µM 1.36802439852856 0.150896461605847 no 546 0.0856522195616921 121 790957
SGTC_2123 5259487 200 µM 1.3677966702075 0.150937345563387 no 547 0.0856878651431825 105 2173474
SGTC_1559 coumarin 343 70.1 µM 1.3673690721923 0.151014131949101 no 548 0.0857548256875606 99 108770 A hepatotoxic, DNA x-linker.
SGTC_483 fpl-64176 144 µM 1.36712191345404 0.151058527606127 no 549 0.0857935478514109 94 3423
SGTC_951 1171-0579 82.7 µM 1.36478966501439 0.151477883157692 no 550 0.0861595840130328 132 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_959 1222-0044 107 µM 1.36344196128856 0.151720562819267 no 551 0.0863716320917695 114 6083612
SGTC_861 0443-0273 110 µM 1.36320074032463 0.151764026484126 no 552 0.0864096270051474 124 6149169
SGTC_1119 parthenolide 318.541 nM 1.36190678106295 0.151997315815452 no 553 0.086613652945277 132 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1687 st020778 55.3625 µM 1.36095266569274 0.152169486812407 no 554 0.0867643242464344 113 4259299
SGTC_1483 3453-0561 55.9 µM 1.35810899132603 0.152683398323961 no 555 0.0872145512922668 130 4546991
SGTC_992 3909-8734 162 µM 1.35787474586121 0.152725782649964 no 556 0.0872517160177477 114 4288319
SGTC_3148 9097893 49.47 µM 1.3557232494468 0.153115438959068 no 557 0.087593619593371 109 17174100
SGTC_3096 9117468 49.47 µM 1.35569479974455 0.153120595878866 no 558 0.0875981473458824 94 41316311
SGTC_2118 5526350 200 µM 1.34953581606654 0.154239710852444 no 559 0.0885824621295049 128 743594
SGTC_851 0394-0702 453 µM 1.34564048481985 0.154950295595499 no 560 0.0892092443031723 150 762646
SGTC_2826 7992541 19.48 µM 1.34159163439927 0.155691173225983 no 561 0.0898642200662892 124 2985066
SGTC_1163 k060-0048 49.9 µM 1.34060607703463 0.155871868096761 no 562 0.0900241915803514 111 6809982
SGTC_1256 0570-0116 285 µM 1.33840263403712 0.156276353451181 no 563 0.0903826103617223 120 410638
SGTC_1833 st055984 71 µM 1.33750904955798 0.156440585363492 no 564 0.0905282651640386 107 676288
SGTC_1463 k081-0032 34.1 µM 1.33693629273816 0.156545912103469 no 565 0.0906217164663636 106 977755
SGTC_2589 lobaric acid 100 µM 1.33416351853447 0.157056469569666 no 566 0.0910751363348437 95 73157 A novel microtubule depolymerizer.
SGTC_2797 7859098 81.82 µM 1.33207699917756 0.157441386665864 no 567 0.0914174438063616 127 972681
SGTC_1432 4049-0298 68.4 µM 1.3302173072627 0.157784981207103 no 568 0.0917233416867679 107 741646
SGTC_921 1561-0023 372 µM 1.3270139020786 0.158377992647142 no 569 0.0922520419835267 136 24050882
SGTC_1662 st014054 52 µM 1.32385495187841 0.158964204615923 no 570 0.0927756108687706 113 2838777
SGTC_1364 1653-0028 37.6 µM 1.32135748207325 0.159428669614356 no 571 0.0931910979324051 106 5718652
SGTC_380 3970-0968 6 µM 1.31862157954334 0.159938495666363 no 572 0.093647827824623 120 2891601
SGTC_1726 st035556 14.5795 µM 1.31666956460132 0.160302898023167 no 573 0.0939747048655456 96 5919439
SGTC_653 0203-0016 55.2 µM 1.31559810013638 0.160503149607295 no 574 0.0941544857894091 131 295302
SGTC_678 1218-2179 85.9 µM 1.31465681157776 0.160679206728759 no 575 0.0943126337611501 128 6820081 YOR116C RPO31
SGTC_1282 0886-0010 32.4 µM 1.31214622857145 0.161149398752016 no 576 0.0947354003212445 141 2836211 YNL267W PIK1
SGTC_1945 st075991 56.6 µM 1.31185134292399 0.161204684971367 no 577 0.094785148741428 126 1084980
SGTC_87 0100-0052 35.5 µM 1.31160136303706 0.16125156178754 no 578 0.0948273364502493 147 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_433 pimozide 108 µM 1.31110042486972 0.161345525651457 no 579 0.0949119186268346 100 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2302 7771753 200 µM 1.30505968605493 0.162481433063032 no 580 0.0959362623700112 111 2203047
SGTC_3118 9124250 49.47 µM 1.3039015828772 0.162699797156785 no 581 0.0961335702590577 117 1504786
SGTC_1965 Pectolinarigenin 58.4 µM 1.30214141843764 0.163032047213754 no 582 0.0964340233253905 116 5320438 An anti-inflammatory.
SGTC_2684 capsaicin 100 µM 1.3014305493786 0.163166356371252 no 583 0.0965555612506131 134 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2809 7964133 12.99 µM 1.29969097288116 0.163495329164056 no 584 0.0968534527659074 127 1253665
SGTC_1790 st045711 43.5 µM 1.29904890402277 0.163616860112009 no 585 0.0969635733422628 83 585119
SGTC_1105 epirubicin 18.1 µM 1.29641227999241 0.164116535743123 no 586 0.0974167417972466 130 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1958 st076513 41.9 µM 1.28671135695677 0.165963501417028 no 587 0.0990974565658751 137 732122 YGL099W LSG1
SGTC_1911 st060208 74.3 µM 1.28378229021342 0.166523798558553 no 588 0.0996090709241275 141 688783
SGTC_728 3030-5151 22.5 µM 1.28231870347235 0.166804223012299 no 589 0.0998654347447137 107 3125388
SGTC_2806 7952793 58.44 µM 1.28230056719367 0.166807699848523 no 590 0.0998686145397655 122 2972490
SGTC_275 trichlorophene 5.69 µM 1.28215242140885 0.166836102057837 no 591 0.0998945913934221 110 62616
SGTC_3322 9139058 2.11 µM 1.28013943220437 0.16722233743482 no 592 0.100248051347526 121 4908926 YPR165W RHO1
SGTC_1722 st034304 3.6505 µM 1.2791541672198 0.167411591692252 no 593 0.100421386003143 133 4036148 YLR033W RSC58
SGTC_1763 st044482 94.5 µM 1.27864495932521 0.167509456777119 no 594 0.100511055064545 141 88505
SGTC_2047 4141938 200 µM 1.27474252635602 0.168260691832045 no 595 0.101200194680334 131 3807862
SGTC_2722 naftopidil 47.16 µM 1.2736412073749 0.168473091959124 no 596 0.101395300652067 123 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1594 piperine 70.1 µM 1.27220246175672 0.16875082770971 no 597 0.101650596595904 121 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1489 4065-0444 182 µM 1.26855683515726 0.169455896738653 no 598 0.102299583876064 126 2877968
SGTC_3330 9141424 71.43 µM 1.26603760705271 0.169944221697976 no 599 0.102749809268572 103 27261020
SGTC_870 0573-2213 57.6 µM 1.26221961799844 0.17068601515135 no 600 0.103434885687776 121 3916321
SGTC_2034 5197015 53.07 µM 1.25652504856974 0.171796252388464 no 601 0.104462835053389 134 780676
SGTC_2329 6138490 200 µM 1.2556783365511 0.171961723929286 no 602 0.104616308319277 132 720019
SGTC_593 1203-0218 61.7 µM 1.25526339218786 0.172042852965513 no 603 0.104691579879114 144 3666956
SGTC_2299 7976368 114.88 µM 1.25502235693197 0.172089990880928 no 604 0.104735322059517 117 2979718
SGTC_1742 st038235 28.8875 µM 1.25455901434139 0.17218062734898 no 605 0.104819444920122 145 564103 YBR002C RER2
SGTC_32 0928-0142 34.1 µM 1.24998955054738 0.173076111249103 no 606 0.105651682262284 139 2244242
SGTC_2643 anethole 100 µM 1.24834459375643 0.173399200526021 no 607 0.105952445009544 142 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2173 5763948 167 µM 1.24571113482157 0.17391724226354 no 608 0.106435232136454 142 2867177
SGTC_3116 9124943 49.47 µM 1.24359204955979 0.174334812645333 no 609 0.106824871877316 119 41905195 YPL160W CDC60
SGTC_1200 1643-0193 18.4 µM 1.23970119853373 0.175103170299815 no 610 0.107542966842958 145 5403974
SGTC_1445 4239-0156 97.7 µM 1.23665325122088 0.175706571123264 no 611 0.108107920601148 132 4008346
SGTC_2687 chenodiol 100 µM 1.23186924445944 0.176656311929391 no 612 0.108998965894913 126 5702181 A cholesterol synthesis inhibitor.
SGTC_3153 9100258 49.47 µM 1.22318260872974 0.178389099167466 no 613 0.110630366367586 133 25236848
SGTC_2476 5806916 10.51 µM 1.22299204709343 0.178427231544418 no 614 0.110666350060244 126 2870194
SGTC_2221 6807166 181.081 µM 1.2221056785708 0.178604665991595 no 615 0.110833832988612 110 674925
SGTC_1071 trifluoperazine 6.31 µM 1.221907535406 0.17864434574897 no 616 0.110871297765844 145 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2461 5755302 26.15 µM 1.21752994279012 0.179522409477572 no 617 0.111701325550864 135 2788904
SGTC_2854 9024559 71.43 µM 1.21595338183381 0.179839301581116 no 618 0.112001340566038 121 3163529
SGTC_2756 carbadox 75.1 µM 1.21482136381989 0.18006705618933 no 619 0.112217115400569 155 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_863 0466-0191 129 µM 1.21279287590694 0.180475627421519 no 620 0.112604509922335 164 765160 YPR165W RHO1
SGTC_1495 4469-0029 237 µM 1.21209088819899 0.180617154770493 no 621 0.112738795634659 134 793680
SGTC_860 0443-0016 25.1 µM 1.21144687006544 0.180747056103414 no 622 0.112862092680415 166 5337942
SGTC_934 2950-0684 338 µM 1.21042893384174 0.180952497805268 no 623 0.113057172485611 154 1121253
SGTC_3138 9097216 49.47 µM 1.21025438887212 0.180987739473278 no 624 0.113090646867039 154 25237486
SGTC_1378 2093-0007 380 nM 1.20991727877244 0.181055816182035 no 625 0.113155318145784 153 3618014
SGTC_1410 3909-8106 77.9 µM 1.20847201472309 0.181347857577542 no 626 0.113432876994215 159 1039210
SGTC_1428 4049-0204 61.7 µM 1.20629079505956 0.181789170066843 no 627 0.113852692820863 161 X1428
SGTC_3103 9120822 49.47 µM 1.20547185694082 0.181955033998553 no 628 0.114010598062586 172 17141819
SGTC_1904 st060225 78 µM 1.20524984890032 0.182000014778125 no 629 0.114053431869611 135 66595
SGTC_1444 4112-3581 28 µM 1.2027803194191 0.182500831880129 no 630 0.114530671310596 142 2877249
SGTC_1508 1080-0625 72.9 µM 1.20216218262444 0.18262632372319 no 631 0.114650349059251 136 767111
SGTC_144 4161-2749 112.381 µM 1.20102759462646 0.182856803760573 no 632 0.114870248690148 163 797501 YMR168C CEP3
SGTC_2366 9070441 60.58 µM 1.19948215099246 0.18317103687133 no 633 0.115170260524181 136 6837235
SGTC_1441 4106-0040 13 µM 1.1971840504323 0.183638929155162 no 634 0.115617412563692 129 2904180
SGTC_1204 4049-0315 18.3 µM 1.19568613027591 0.18394430560173 no 635 0.115909532923054 132 588402
SGTC_1574 spiramycin 23.7 µM 1.19451042900392 0.184184213630333 no 636 0.116139181822449 156 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2114 5491910 81.25 µM 1.19445293742469 0.184195950081697 no 637 0.116150419887826 135 2849228
SGTC_2467 5474540 200 µM 1.19375418340742 0.18433863239479 no 638 0.116287069297535 141 5413519
SGTC_232 clozapine 119 µM 1.1907562375583 0.184951579083218 no 639 0.116874646706531 134 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1966 st070145 16.1 µM 1.19073981001965 0.184954941269798 no 640 0.11687787218129 160 3748532
SGTC_509 pifithrin 175 µM 1.19004943416598 0.185096273243456 no 641 0.117013481481892 148 4817 A p53 inhibitor.
SGTC_1770 st043884 66.3 µM 1.1895634422071 0.185195804494823 no 642 0.117109010864263 172 670149
SGTC_1006 4099-6547 255 µM 1.18914645752187 0.185281229532126 no 643 0.117191019812527 147 3146833
SGTC_1272 0839-0021 27 µM 1.18833236730754 0.18544807758922 no 644 0.117351245276182 153 5027250
SGTC_2353 9059630 146.67 µM 1.18782761660479 0.185551573234994 no 645 0.117450665851459 145 4779114
SGTC_2269 7935389 174.42 µM 1.18728705325971 0.185662451756857 no 646 0.117557206553116 141 97605
SGTC_793 0488-0545 106 µM 1.18510080386471 0.186111307025144 no 647 0.117988796646283 140 292548
SGTC_2995 9067767 71.4286 µM 1.18278974772833 0.186586516797263 no 648 0.118446242373701 122 11673567
SGTC_3125 9127534 49.47 µM 1.18196123534082 0.18675706204432 no 649 0.11861054127949 125 1639235
SGTC_1343 1487-0095 224 µM 1.18126259458736 0.186900948808759 no 650 0.118749210970652 162 4560101 YGL055W OLE1
SGTC_2747 doxorubicin 7.63 µM 1.17760129837232 0.187656122880305 no 651 0.119477796007744 90 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3235 9132602 49.47 µM 1.17653450591527 0.187876512221275 no 652 0.11969067604115 160 4912240
SGTC_1753 st043925 64 µM 1.17634428142823 0.187915827604803 no 653 0.119728663707198 138 670181
SGTC_2436 5633522 8.09 µM 1.17406962836664 0.188386343813833 no 654 0.120183568738563 152 5724242
SGTC_1768 st044301 37.178 µM 1.17368304493915 0.188466381498468 no 655 0.120261001993666 183 3931349
SGTC_233 rapamycin 362 pM 1.173077971419 0.188591697154065 no 656 0.12038226969816 149 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2292 7671323 168.05 µM 1.17208964842318 0.188796497356672 no 657 0.120580532741272 184 937504
SGTC_2308 7584454 197.62 µM 1.17108411818573 0.189005003844324 no 658 0.120782483490251 151 893577
SGTC_2176 5809774 33.9695 µM 1.16656195611733 0.189944470496103 no 659 0.121693657259676 119 2870539
SGTC_2420 aureobasidin a 50 nM 1.16650254727124 0.189956831592748 no 660 0.121705659650425 125 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_982 1491-0518 27.5 µM 1.16487669038659 0.190295312769849 no 661 0.122034455037008 127 3091256
SGTC_2331 7980721 200 µM 1.16081445069038 0.191142633420669 no 662 0.122858682507562 165 2981221
SGTC_492 tmb-8 126 µM 1.159089090746 0.19150321576846 no 663 0.123209936092055 133 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2916 7875993 68.79 µM 1.15875540426147 0.191573000848978 no 664 0.123277950051061 152 1299250
SGTC_2729 fluphenazine 10.66 µM 1.15418817013739 0.192529728386471 no 665 0.124211515749341 167 3372 An atypical antipsychotic.
SGTC_323 4013-0906 34.3 µM 1.14911521551799 0.193595809389084 no 666 0.125254237558789 142 2910086
SGTC_943 3253-1379 105 µM 1.14835415348145 0.193756056509059 no 667 0.125411195936663 168 668464
SGTC_928 2764-0428 58.7 µM 1.14811453689307 0.193806526249289 no 668 0.12546064190424 174 662578
SGTC_748 act1.228 77.9 µM 1.14659212796322 0.194127373951567 no 669 0.125775115728897 135 4421505 YNR035C ARC35
SGTC_52 0329-0193 875 nM 1.14621793921887 0.194206283743465 no 670 0.125852493500618 155 3739292
SGTC_508 roscovitine 141 µM 1.14252821848989 0.194985426238703 no 671 0.12661726173136 169 160355 A CDKinase inhibitor.
SGTC_691 1548-0686 185 µM 1.14001306760156 0.195517627564563 no 672 0.127140428499872 182 46495133
SGTC_1621 st003705 32.4 µM 1.13692612775127 0.196172022806125 no 673 0.127784584292857 146 24207032
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.13336828294837 0.196927889723696 no 674 0.128529813832747 152 4620898
SGTC_496 calpeptin 138 µM 1.13310568261823 0.196983749152651 no 675 0.128584937637834 139 73364 A calpain inhibitor.
SGTC_147 4466-0538 29.23 µM 1.13160561334934 0.197303022507862 no 676 0.128900139542844 160 6742687 YHR072W ERG7
SGTC_731 3966-0296 387 µM 1.13081717692204 0.19747095801099 no 677 0.129066024354548 146 660956
SGTC_2098 5376439 882.5 nM 1.12609486067744 0.198478610544017 no 678 0.130062684580719 151 2844116
SGTC_590 k048-0076 22.4 µM 1.12551524035744 0.198602503888145 no 679 0.130185381376013 154 6832814
SGTC_1362 1611-0397 101 µM 1.12520156962517 0.198669570183601 no 680 0.130251814083007 155 27816
SGTC_2360 9040895 200 µM 1.12489205182578 0.198735761921357 no 681 0.13031739022268 139 4914414
SGTC_1118 chelidonine 707.474 nM 1.12346274108396 0.19904159872753 no 682 0.130620508077057 142 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2231 micatex 6.853 µM 1.12331537109365 0.199073148344357 no 683 0.130651788935116 157 20737 An antifungal of unknown mechanism.
SGTC_2105 5350118 200 µM 1.12100422594956 0.199568322518656 no 684 0.131143031796643 165 2133313
SGTC_1863 st057641 20.1 µM 1.11647103717376 0.200541730776858 no 685 0.132110280480548 167 3921635
SGTC_1806 st050005 60.3 µM 1.10895393493075 0.202162142508019 no 686 0.133725027359061 156 5194765
SGTC_2595 hexamethylquercetagetin 100 µM 1.10817653818316 0.202330166555414 no 687 0.133892790626859 172 386331
SGTC_1087 pterostilbene 9.05 µM 1.10614730577819 0.202769151736005 no 688 0.134331383075859 175 5281727 Similar to reservatol, lowers cholesterol.
SGTC_458 nppb 133 µM 1.10078407567932 0.203932119177799 no 689 0.135495322010503 136 4549 A chloride channel blocker.
SGTC_1396 3511-0007 98.6 µM 1.09810958551701 0.204513540141523 no 690 0.136078320100395 171 X1396
SGTC_1818 st052136 56.3 µM 1.09734421314387 0.204680109693559 no 691 0.136245475142357 172 674169
SGTC_2849 9019321 12.99 µM 1.09682878444224 0.204792328955689 no 692 0.136358122370524 154 16489627
SGTC_2051 5263410 176 µM 1.09477160063783 0.205240583845751 no 693 0.136808355589295 156 227584
SGTC_2363 9053361 176 µM 1.09394452207875 0.205420966234773 no 694 0.136989655272888 167 6469797 YMR079W SEC14
SGTC_3217 9129673 49.47 µM 1.0933091491195 0.205559602354346 no 695 0.137129043606694 165 17248312
SGTC_404 fumagillin 50 µM 1.09291057445952 0.205646598272369 no 696 0.137216532488158 171 12015870 A methionine aminopeptidase binder.
SGTC_1631 benzylvanillin 81.9 µM 1.08790207629629 0.206741652477307 no 697 0.138319169715075 143 75506
SGTC_2010 4012422 159 µM 1.08434641579607 0.207521150624396 no 698 0.139105616250397 160 952393
SGTC_838 0109-0203 71.4 µM 1.08371079658071 0.207660678542671 no 699 0.139246523536154 157 759422
SGTC_2749 bexarotene 57.39 µM 1.08313148808447 0.207787893681168 no 700 0.139375032148956 162 82146 An retinoic acid receptor inhibitor.
SGTC_1375 2910-0797 186 µM 1.08047274286107 0.208372339645268 no 701 0.139965859106433 160 742508
SGTC_1063 disulfiram 1.84 µM 1.07798365135758 0.208920370082598 no 702 0.140520526045294 175 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1920 st075728 45.7 µM 1.07770071751027 0.208982718139276 no 703 0.140583669089485 155 3400306
SGTC_2744 captopril 92.04 µM 1.07655935191045 0.209234343758472 no 704 0.140838585996882 102 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_663 1486-0733 13.9 µM 1.07641208061706 0.209266824193951 no 705 0.140871500952662 172 722445 YPR165W RHO1
SGTC_1369 1866-0067 208 µM 1.07580993547467 0.20939965716082 no 706 0.141006133949549 159 3531355
SGTC_1355 1499-0035 1.68 µM 1.07520331142771 0.209533528328157 no 707 0.14114185659848 165 1548538
SGTC_822 1487-0950 154 µM 1.07515740284212 0.20954366158749 no 708 0.141152131531237 164 1958375
SGTC_2524 avocatin b 10.57 µM 1.07331655481027 0.209950223722299 no 709 0.141564554966268 128 6710748
SGTC_747 3448-8087 38.7 µM 1.07312880394711 0.209991715641858 no 710 0.141606664488452 156 5168703
SGTC_176 1486-1328 72.834 µM 1.07299019740725 0.210022350024668 no 711 0.141637757167521 165 22310231
SGTC_140 0062-0056 502.533 µM 1.0726414427292 0.210099442304929 no 712 0.141716011431718 143 3758964
SGTC_1485 3909-9022 254 µM 1.07047907592634 0.210577804799479 no 713 0.142201861193439 176 714516
SGTC_2531 methyl deoxycholate 70.07 µM 1.07018145148213 0.210643695791228 no 714 0.14226882086144 167 16667744 Haematoxylin.
SGTC_2742 clothiapine 36.27 µM 1.06926444783384 0.210846787008305 no 715 0.142475262825688 125 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2296 7971656 126.45 µM 1.06719009958795 0.211306621839035 no 716 0.142943001159097 141 666570
SGTC_2071 5230951 39.92 µM 1.06247920453379 0.212353097300184 no 717 0.144009096857605 179 1799272
SGTC_1919 st067113 52.3 µM 1.06153676290714 0.212562813681582 no 718 0.144223017469898 181 1268243
SGTC_773 4358-1457 44.6 µM 1.06039030776288 0.212818091088046 no 719 0.144483534866225 180 1186886
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.05688777166789 0.213599096965086 no 720 0.145281404967583 140 88881 An O-methylated flavonoid and antioxidant.
SGTC_613 3914-0030 117 µM 1.05670486796411 0.213639927202499 no 721 0.14532315131839 130 1145395
SGTC_2095 5432005 200 µM 1.05488568827813 0.214046276535999 no 722 0.145738804246431 173 783734
SGTC_503 tyrphostin 8 294 µM 1.0529174501555 0.214486427211252 no 723 0.146189413828736 186 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_285 1486-1325 46 µM 1.05245073131057 0.214590875159641 no 724 0.146296401820493 186 22310230
SGTC_657 3534-0529 86.7 µM 1.05243512169486 0.214594368977781 no 725 0.146299980989045 179 1049549
SGTC_368 fentichlor 4.58 µM 1.0523415827576 0.214615305998593 no 726 0.146321430002162 177 7329 A pesticide.
SGTC_1236 0330-0013 258 µM 1.05222286558486 0.214641880427459 no 727 0.146348655569075 153 4617066
SGTC_781 4335-2806 94.4 µM 1.04667306396424 0.215886317253728 no 728 0.147625195532899 183 845254
SGTC_1826 st055655 41.6 µM 1.04654032517787 0.215916132491054 no 729 0.147655818548347 160 676168
SGTC_2345 9052315 157.45 µM 1.04598462199796 0.216040978141052 no 730 0.147784066202003 166 6469265
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.04597204164953 0.216043804957179 no 731 0.147786970413953 165 5355888
SGTC_2981 9013952 38.96 µM 1.04536347313427 0.21618057646 no 732 0.147927505958359 169 2996344
SGTC_1704 st028805 70.8 µM 1.04251129509475 0.216822251244534 no 733 0.14858734575424 190 2876101
SGTC_2257 7960413 200 µM 1.04179776048772 0.216982952239627 no 734 0.148752726336606 181 2974689 YIL048W NEO1
SGTC_481 bay k-8644 50 µM 1.03978885957611 0.217435762880437 no 735 0.14921900300411 179 2303 A calcium channel antagonist.
SGTC_2287 7945887 168.79 µM 1.03970933469511 0.217453699180069 no 736 0.149237481216246 168 1245853
SGTC_3094 9117742 49.47 µM 1.03942623772598 0.217517556720858 no 737 0.149303273355177 211 17149698
SGTC_1039 k821-0043 94 µM 1.03856886006287 0.217711019472252 no 738 0.149502647267453 157 15992768
SGTC_2349 9023730 187.07 µM 1.03526214003017 0.21845809254622 no 739 0.150273252848271 163 4126287
SGTC_1243 0416-0003 5.65 µM 1.03331084843703 0.218899631246992 no 740 0.150729226027149 165 2141977
SGTC_1305 1181-0477 144 µM 1.03240508621962 0.2191047616649 no 741 0.150941195124566 186 6252086
SGTC_2851 9015922 71.43 µM 1.03165799220211 0.219274041217802 no 742 0.151116181472082 189 2996893
SGTC_2108 5365811 200 µM 1.03069959747445 0.219491308159017 no 743 0.151340856793001 165 780283
SGTC_976 1348-1067 47.6 µM 1.02988371772608 0.219676364536069 no 744 0.151532297472988 167 5310671 YGL099W LSG1
SGTC_1038 k292-0204 154 µM 1.02946266327996 0.219771902384824 no 745 0.151631158013829 171 4454212
SGTC_295 k015-0027 31 µM 1.0270280835742 0.220324779427492 no 746 0.152203620165222 140 3887424
SGTC_2178 5812956 200 µM 1.02582593307314 0.220598073706368 no 747 0.152486819945067 182 5403383
SGTC_958 1222-0007 33 µM 1.02500979711854 0.220783722908586 no 748 0.152679282481974 194 7312461
SGTC_2228 7354201 200 µM 1.02456053289449 0.220885956728348 no 749 0.15278529745477 212 753451
SGTC_929 2805-0021 398 µM 1.01827983390373 0.222318017179535 no 750 0.154272494574895 195 3098024
SGTC_1923 st058458 19.1 µM 1.01334373882407 0.223447202445213 no 751 0.155448001235773 206 3534982
SGTC_2920 7982904 15.77 µM 1.01223591161039 0.223701077522774 no 752 0.155712634713022 182 6456808
SGTC_2654 protoveratrine a 100 µM 1.01165313701448 0.223834694786337 no 753 0.155851964834311 199 5702278 A heart drug and vasodilator.
SGTC_1624 st003710 6.25 µM 1.01070649964349 0.224051834354005 no 754 0.15607846263865 172 24207033
SGTC_2138 5575593 77.673 µM 1.01022536937082 0.224162241806371 no 755 0.156193663685468 166 762213
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.00817409035347 0.224633305940999 no 756 0.156685447004565 187 5282362
SGTC_1845 st056753 3.01 µM 1.00628758169332 0.225067026772876 no 757 0.157138626199202 166 5375839
SGTC_112 phenothiazine 287.218 µM 1.00585669029644 0.225166158084969 no 758 0.157242256210729 178 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1998 st075797 76.8 µM 1.00435352881404 0.22551217052157 no 759 0.157604120464228 179 24208315
SGTC_3017 9080681 49.47 µM 1.00191852307976 0.226073322119462 no 760 0.158191472826118 183 16451914
SGTC_2313 7726885 200 µM 0.997501281355947 0.227093295363968 no 761 0.159260626074928 188 726423
SGTC_925 2064-1272 59.6 µM 0.99568249521937 0.22751401915329 no 762 0.15970221895402 190 6815817
SGTC_975 1335-0046 28.5 µM 0.994623661728675 0.227759151807486 no 763 0.159959667464858 188 16486740
SGTC_1227 3909-8010 46.6 µM 0.993709043988043 0.227971016391926 no 764 0.160182269216094 157 15982272
SGTC_926 2268-1401 59.4 µM 0.993697377696039 0.22797371951996 no 765 0.1601851098922 204 2931578
SGTC_1008 4106-0037 6 µM 0.992754773413171 0.228192184395746 no 766 0.160414737524254 208 2905394
SGTC_517 1365-0151 113 µM 0.991853585814267 0.228401160248734 no 767 0.160634476665595 170 768657
SGTC_2406 ethylparaben 405.7 µM 0.990744740425802 0.228658437241021 no 768 0.160905119233546 156 8434 A possible steroid mimic.
SGTC_227 fluconazole 33.516 µM 0.990495813663629 0.228716216190695 no 769 0.160965917174681 224 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_196 k015-0023 18.111 µM 0.990206145732451 0.228783461983067 no 770 0.161036684623832 170 5211998
SGTC_2532 xanthone 78.9 µM 0.98887551217029 0.229092508281349 no 771 0.1613620264523 162 7020 An insecticide.
SGTC_2691 st077356 60.2 µM 0.98886661358418 0.229094575810408 no 772 0.161364203611434 185 2839272
SGTC_1194 1488-0194 225 µM 0.98864896298401 0.229145148781467 no 773 0.161417460731739 186 1391452
SGTC_597 k018-0003 82.8 µM 0.988041767604824 0.229286268895129 no 774 0.161566096499549 206 6786234
SGTC_358 0075-0058 9.45 µM 0.987612650103184 0.229386030770172 no 775 0.161671194257734 186 1069125
SGTC_2769 toremifene 3.73 µM 0.987417155612974 0.229431487685602 no 776 0.161719088764715 205 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2161 5662504 8.5105 µM 0.985889692735322 0.229786831322293 no 777 0.162093622680825 167 2859334
SGTC_1783 st039459 87.517 µM 0.984978624514496 0.229998925693253 no 778 0.162317285356666 194 729761
SGTC_1778 st046819 58.9 µM 0.984337498739409 0.230148243799153 no 779 0.162474798888624 220 671715
SGTC_2365 9042475 200 µM 0.984284886379479 0.23016049961793 no 780 0.162487729251754 194 6464479
SGTC_2962 9082311 13.18 µM 0.983339706994535 0.23038073720074 no 781 0.162720136888051 193 16459453
SGTC_2603 homopterocarpin 100 µM 0.981447731219418 0.230821942928377 no 782 0.163185999002034 176 101795 A weak amylase inhibitor.
SGTC_2333 9017922 200 µM 0.979331158380842 0.23131608307936 no 783 0.163708189887398 163 3163164
SGTC_225 nsc-122657 1.016 µM 0.978762376735315 0.231448972714676 no 784 0.163848701732066 177 275685
SGTC_1848 st056003 16.4 µM 0.978712063017285 0.23146073001574 no 785 0.163861135002241 189 146492
SGTC_2181 6316240 54.2555 µM 0.977662777764358 0.231706002690068 no 786 0.164120568565089 178 12779990
SGTC_228 caffeine 993.056 µM 0.977583865251781 0.231724454512388 no 787 0.16414009028311 144 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2281 7943571 200 µM 0.975641984216526 0.232178775286674 no 788 0.164620955706183 198 1244024
SGTC_1420 4'-methoxyflavone 42 µM 0.973442498226742 0.232693963282265 no 789 0.165166712878647 181 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_42 0133-0086 60.653 µM 0.970884514582524 0.233293920891747 no 790 0.165802895141044 230 162923 Model of phenazepam hydroxylation.
SGTC_1092 toremifene 6.32 µM 0.97061865525834 0.233356325590297 no 791 0.165869106329545 197 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1640 st009078 66.4 µM 0.969163027292741 0.233698166752299 no 792 0.166231927481146 201 690618
SGTC_3066 9117245 49.47 µM 0.969043392857059 0.233726274165667 no 793 0.166261769626701 180 17176980
SGTC_2918 7977171 22.06 µM 0.968270829600192 0.233907828516047 no 794 0.166454564551278 190 2236483
SGTC_1189 1431-2119 7.28 µM 0.967819404107629 0.23401395082456 no 795 0.16656728559527 201 3107275
SGTC_2239 6685329 187.64 µM 0.964999125903767 0.234677552754486 no 796 0.167272624796837 164 805680
SGTC_2670 beta-carotene 100 µM 0.964373232018314 0.234824964431875 no 797 0.167429418758661 148 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1567 st069303 68.4 µM 0.964000840006809 0.234912695161798 no 798 0.167522752365039 203 5581319
SGTC_2949 9072542 2.23 µM 0.96225573056152 0.23532406155068 no 799 0.167960580287761 191 16457352
SGTC_1020 4335-0961 93.3 µM 0.958853784874867 0.236127128091694 no 800 0.168816204705832 206 669075
SGTC_2000 st075254 36.4 µM 0.9572217164547 0.236512930929308 no 801 0.169227679082722 177 17234175
SGTC_126 0417-1624 672.48 µM 0.956484462739953 0.236687323194003 no 802 0.169413765213212 240 41912 YDL195W SEC31
SGTC_2726 cimetidine 79.27 µM 0.955549639179257 0.236908550905402 no 803 0.169649907602882 218 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1222 0366-0074 1.18 µM 0.955168805413942 0.236998708492351 no 804 0.169746169138143 204 286520
SGTC_2006 4011487 200 µM 0.953070862109652 0.237495708006962 no 805 0.170277084113489 193 45595294
SGTC_2495 cafestol 54.53 µM 0.95233671245324 0.23766976195132 no 806 0.170463122328744 205 16667697 An anti-infammatory.
SGTC_1628 st004252 77.7 µM 0.946900978686535 0.238960653528634 no 807 0.171844619598474 185 692968
SGTC_876 0720-0963 56.8 µM 0.946399031821866 0.239080050167149 no 808 0.17197254951877 191 765861
SGTC_564 3555-0129 330 µM 0.946196545480994 0.239128224232147 no 809 0.172024173904163 201 563260
SGTC_1035 k081-0041 55.2 µM 0.945861927721464 0.239207845661436 no 810 0.172109507196219 210 731709
SGTC_1916 st067606 49.2 µM 0.944380135701205 0.239560608287209 no 811 0.172487714335687 200 19590279
SGTC_828 2074-0507 139 µM 0.943906952049394 0.239673316487874 no 812 0.172608599559683 195 X828
SGTC_2833 9001315 45.46 µM 0.940805348345009 0.240412807362507 no 813 0.173402309790236 186 2989378
SGTC_1387 3342-1166 1.8 µM 0.939002794875411 0.240843146285736 no 814 0.173864654691434 174 3418228
SGTC_2506 ethyl hematommate 54.16 µM 0.938964364443542 0.240852325670138 no 815 0.173874520410502 189 3940691 An allergen.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.936006897285113 0.241559308546738 no 816 0.174634818257083 189 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_560 2332-1943 155 µM 0.935036408940485 0.241791549226842 no 817 0.174884768150903 198 21177716
SGTC_445 e6 berbamine 66 µM 0.93479933290947 0.241848300619566 no 818 0.174945861722501 223 6610268 A calcium/calmodulin antagonist.
SGTC_1737 st035557 69.7 µM 0.93219970022976 0.242471076024517 no 819 0.175616665186465 197 5716916
SGTC_291 SEC14.278 35.5 µM 0.929735691416748 0.243062161963396 no 820 0.17625397500528 192 1068044
SGTC_3275 9138069 49.47 µM 0.928851419586393 0.243274477950503 no 821 0.176483046170853 221 17617007
SGTC_1950 st077106 7.18 µM 0.928454069101829 0.243369915477389 no 822 0.176586041354866 178 13831864
SGTC_712 r015-0009 80.6 µM 0.928117111975825 0.243450863290903 no 823 0.176673412064553 187 6813872 YLR060W FRS1
SGTC_169 k015-0017 16.025 µM 0.927746321780592 0.243539955690657 no 824 0.176769587042713 221 1840002
SGTC_305 1682-2595 20.8 µM 0.927341182874036 0.243637321429146 no 825 0.176874709165351 209 226033
SGTC_1116 jasmonic acid 1.58368 µM 0.926751951390374 0.243778967056379 no 826 0.177027668624546 199 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1814 st052110 31.539 µM 0.926542581633022 0.243829308249866 no 827 0.177082039343315 194 674163
SGTC_2189 6047310 154.431 µM 0.926372434943902 0.243870222719231 no 828 0.177126232089027 190 711535
SGTC_545 4218-0007 221 µM 0.925918583199387 0.243979376687011 no 829 0.177244146532287 213 2840508
SGTC_226 1,3-diallylurea 8.28947 mM 0.92483448637608 0.244240214876477 no 830 0.177526004446202 191 74537 YKL182W FAS1
SGTC_2267 7931562 200 µM 0.92436794206939 0.244352513623307 no 831 0.177647389864119 175 934880
SGTC_2792 7535235 81.82 µM 0.922347581589019 0.244839142039495 no 832 0.178173651183176 200 1281891
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.919219276249408 0.245593660402396 no 833 0.178990445292665 208 165506
SGTC_2629 bisabolol 100 µM 0.917567510553275 0.245992554274063 no 834 0.179422666862576 233 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2708 st078559 56 µM 0.91642233288635 0.246269313362598 no 835 0.179722713129679 182 17250902
SGTC_2755 lomerizine 42.69 µM 0.916239976261052 0.246313399528275 no 836 0.17977052119346 187 3949 A calcium channel blocker.
SGTC_2442 5158906 48.48 µM 0.916203046308296 0.246322328153424 no 837 0.179780204016426 200 1893835
SGTC_2759 disulfiram 3.38 µM 0.914211482184692 0.246804089270677 no 838 0.180302865958311 210 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_263 alizarin 107.927 µM 0.913712538487818 0.246924863158337 no 839 0.180433956919752 228 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_741 4582-0002 126 µM 0.911988282666328 0.247342478461515 no 840 0.180887442892804 212 2912688
SGTC_3003 9075612 71.4286 µM 0.910416493925169 0.247723494893264 no 841 0.181301451236919 229 6501993
SGTC_3263 9137018 49.47 µM 0.910028134003288 0.247817685268904 no 842 0.181403836386519 217 43844957
SGTC_164 4100-3994 89.624 µM 0.904060260790733 0.249267496913485 no 843 0.182981724370515 225 4615967
SGTC_2994 9053520 71.4286 µM 0.903132454818855 0.249493298832285 no 844 0.183227800485896 180 4647384
SGTC_3298 9116858 71.43 µM 0.902074715993185 0.249750855288787 no 845 0.183508589505457 224 2506942
SGTC_172 1112-0046 2.638 µM 0.899598988068659 0.250354239658825 no 846 0.184166847961373 191 2802135 YIL048W NEO1
SGTC_1899 st063254 59.6 µM 0.899535204854614 0.250369795107204 no 847 0.184183826345945 195 3093813
SGTC_2772 vinpocetine 57.06 µM 0.89779642494909 0.250794045980185 no 848 0.184647045492894 210 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2251 lansoprazole 556 µM 0.897123881641941 0.250958244152072 no 849 0.184826408299376 195 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1400 3771-8998 51.5 µM 0.894866827964927 0.251509708387999 no 850 0.18542914059624 182 670767
SGTC_1132 3456-3614 2.5 µM 0.894348721184636 0.251636387331399 no 851 0.185567669817884 187 3125502
SGTC_907 3448-6986 75.5 µM 0.89315089734557 0.251929388482264 no 852 0.185888184734184 212 590582
SGTC_2293 7624732 200 µM 0.89278014955557 0.252020114028293 no 853 0.185987459336657 198 894453
SGTC_1281 0884-0031 11.8 µM 0.891667417126749 0.252292513824384 no 854 0.186285611429059 223 1548255
SGTC_3240 9133527 49.47 µM 0.89068758206647 0.252532508465684 no 855 0.186548399276343 215 17617455
SGTC_1819 st053448 58.6 µM 0.890460634049816 0.25258811283794 no 856 0.186609298555316 239 2857616
SGTC_840 0245-0196 390 µM 0.885121728527045 0.253898052608827 no 857 0.188045490744445 198 3827528
SGTC_3317 9138495 8.753 µM 0.885027725391978 0.253921148869479 no 858 0.188070839026636 220 17020139
SGTC_110 0850-0284 111.64 µM 0.88419991462349 0.254124586847371 no 859 0.18829415222054 183 3906265
SGTC_217 ketoconazole 989 nM 0.883741750986526 0.254237219228501 no 860 0.188417818377772 207 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3152 9099253 49.47 µM 0.88283522429286 0.254460151778963 no 861 0.188662652923729 233 25236131
SGTC_1979 st071809 45.3 µM 0.882744190939081 0.254482544310016 no 862 0.188687250024894 219 4976333
SGTC_3008 9078912 71.4286 µM 0.881093989371541 0.254888642483543 no 863 0.189133475120054 220 16648731
SGTC_3355 9151058 44.0485 µM 0.880373430990889 0.255066071046748 no 864 0.189328522395613 208 17015728
SGTC_35 0133-0054 64.071 µM 0.877696722257979 0.255725742711087 no 865 0.190054161870216 222 99677
SGTC_1892 st058411 7.36 µM 0.877646872447362 0.255738036580878 no 866 0.190067692043808 224 3934738
SGTC_487 nimodipine 119 µM 0.876288024540879 0.256073271992637 no 867 0.190436736822555 195 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1292 0kpi-0043 232 µM 0.875944315363543 0.25615810328368 no 868 0.19053015328425 219 3333905
SGTC_2990 9074105 71.4286 µM 0.874928891501056 0.256408806887209 no 869 0.190806298876907 216 6502001
SGTC_2326 6164455 177.58 µM 0.873918021793845 0.256658513028808 no 870 0.191081449756853 220 2888790
SGTC_3321 9137793 26.8275 µM 0.87362661115635 0.256730521109594 no 871 0.191160814627353 223 4904192
SGTC_956 1185-0240 191 µM 0.873034042278357 0.25687697835257 no 872 0.191322261422984 212 1416193
SGTC_3053 9095903 49.47 µM 0.872257468882159 0.257068979310682 no 873 0.191533967167593 261 17174018
SGTC_2936 9038235 15.59 µM 0.872076878160215 0.257113639476457 no 874 0.191583219510753 219 4749415
SGTC_1937 st074714 47.2 µM 0.871830445566394 0.257174588875276 no 875 0.191650441362872 189 17250970
SGTC_530 4358-1714 28 µM 0.871414852158706 0.257277393300897 no 876 0.191763839599483 222 1564641
SGTC_3046 9092212 49.47 µM 0.871334706818878 0.25729722113362 no 877 0.191785712669439 225 25236637
SGTC_1479 0549-0158 134 µM 0.870441068148468 0.257518359742655 no 878 0.192029705812856 208 5440202
SGTC_3083 9117465 49.47 µM 0.870318222064453 0.257548766783881 no 879 0.192063261733686 223 16420915
SGTC_859 0439-0102 54.6 µM 0.869222261764034 0.257820122974806 no 880 0.192362786636589 236 610143
SGTC_1223 0764-0573 147 µM 0.868213882389571 0.258069925414132 no 881 0.192638627923642 203 1609797
SGTC_795 0685-0265 78 µM 0.867404089105193 0.258270623622328 no 882 0.192860321081238 217 302754
SGTC_2052 5265182 7.135 µM 0.867369093563054 0.258279298699171 no 883 0.192869905151795 214 1239884
SGTC_121 0557-0495 61.343 µM 0.865495412820988 0.258743987529316 no 884 0.193383466294184 243 3104427
SGTC_1185 1319-0113 81.3 µM 0.865248640570949 0.258805221388363 no 885 0.193451166751877 222 4672763
SGTC_2466 5983409 37.09 µM 0.860743958550372 0.259924325854254 no 886 0.194689538300597 208 2879657
SGTC_1596 piperlongumine 63 µM 0.858845457050346 0.260396719780035 no 887 0.195212892315406 199 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1689 st020265 53.493 µM 0.858446325395985 0.260496089792924 no 888 0.195323028363789 212 5758320 YPR016C TIF6
SGTC_328 k915-0120 63.5 µM 0.857773564371555 0.260663628263743 no 889 0.195508754889455 188 6624543
SGTC_3288 9119690 36.221 µM 0.855275274622596 0.261286265300174 no 890 0.196199386138643 229 17595618 YKL019W RAM2
SGTC_317 4495-0002 170 µM 0.854264020682892 0.261538512434091 no 891 0.196479358879482 196 15991618
SGTC_495 decylubiquinone 155 µM 0.85409373551987 0.26158100065145 no 892 0.196526527325376 213 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1602 st001878 87.6 µM 0.853581129888845 0.261708923367131 no 893 0.196668558856366 241 595405 YLR310C CDC25
SGTC_401 neomycin 50 µM 0.852267040389284 0.262037006032544 no 894 0.197032947503049 206 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_535 2293-4129 48.2 µM 0.85224329440097 0.262042936522629 no 895 0.197039535870817 246 396118 YIL048W NEO1
SGTC_256 clotrimazole 625 nM 0.852030975772429 0.262095965527332 no 896 0.197098449987204 215 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2757 clomiphene 4.22 µM 0.847580954055627 0.263208673576364 no 897 0.198335692501926 247 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2865 9030313 51.95 µM 0.845611031997148 0.263702013192474 no 898 0.198884884602355 212 42562754
SGTC_3272 9137413 49.47 µM 0.840788646148224 0.264911700080261 no 899 0.200233174433222 229 17614870
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.839040472711311 0.265350921728402 no 900 0.200723299191395 233 66535 A nucleotide analog.
SGTC_2690 usnic acid 100 µM 0.837991470657664 0.265614656660799 no 901 0.201017746921936 226 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2012 4023501 200 µM 0.835488575943533 0.266244458669295 no 902 0.201721338245926 246 3477460
SGTC_923 1900-2434 73.3 µM 0.834834372136426 0.266409200132324 no 903 0.201905485006613 250 5910570
SGTC_1992 st073643 23.3 µM 0.833754052408924 0.266681358869519 no 904 0.202209796052625 223 3161292
SGTC_2970 9090938 41.86 µM 0.833533458378492 0.26673694913005 no 905 0.202271968041369 221 17217104
SGTC_1782 st039423 80.636 µM 0.832023053306689 0.267117732349153 no 906 0.202697966095831 211 2068169
SGTC_1333 1482-0047 286 µM 0.831799761193917 0.267174049059438 no 907 0.202760989364893 225 3811116
SGTC_1711 st032263 62.8 µM 0.83115731922488 0.267336113362864 no 908 0.202942381226477 237 3958979
SGTC_3161 9100388 49.47 µM 0.828594656796065 0.267983071249734 no 909 0.203666906258678 245 25236368
SGTC_532 1548-0774 215 µM 0.828119834635393 0.268103029160513 no 910 0.203801318826719 238 5932993
SGTC_1513 0337-0559 19 µM 0.827770829202403 0.26819121827123 no 911 0.203900148927118 224 775073
SGTC_2546 rhodinyl acetate 100 µM 0.827766648821633 0.268192274687268 no 912 0.203901332885351 232 6708682
SGTC_3335 9143315 29.6265 µM 0.827030798053724 0.268378262747211 no 913 0.204109802745069 220 4899691
SGTC_343 4130-2827 29.8 µM 0.820068923717908 0.270141097003652 no 914 0.206088408375416 217 1118244
SGTC_3029 9088683 49.47 µM 0.815581834234158 0.27128034598764 no 915 0.207369671341105 217 25236615
SGTC_534 k292-0788 63.4 µM 0.81555567287182 0.271286995238413 no 916 0.207377155352068 262 4146317
SGTC_1996 st072960 66.8 µM 0.815226148283287 0.271370755156802 no 917 0.20747143650169 221 1719405
SGTC_2893 9048488 25.97 µM 0.814799371453163 0.271479254199662 no 918 0.20759358039406 247 6467338
SGTC_2195 6536160 144.242 µM 0.814471797525451 0.271562547644343 no 919 0.207687361148706 226 3834386
SGTC_1066 ketoconazole 628 nM 0.813590102235323 0.271786802803409 no 920 0.207939904969778 237 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_354 2783-3500 4.88 µM 0.812352153936147 0.272101824742769 no 921 0.208294796114687 226 6740761
SGTC_654 1124-0271 80.9 µM 0.809186239615003 0.27290828296441 no 922 0.209204014357416 238 5403748
SGTC_2439 5492030 7.2 µM 0.80870409518923 0.273031204277827 no 923 0.209342686024163 230 5722370
SGTC_1796 st049173 110.4 µM 0.806776239146151 0.27352297964846 no 924 0.209897705458566 241 94134
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.805624649034162 0.273816946930621 no 925 0.210229654292308 230 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.804939069375867 0.2739920295301 no 926 0.210427420728743 255 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1270 0831-1170 17.3 µM 0.804763943151312 0.274036761948029 no 927 0.210477956199951 225 6764716
SGTC_1694 st024011 44.9 µM 0.804574023227613 0.27408527719297 no 928 0.210532768680163 252 2787533
SGTC_85 0868-0259 160.055 µM 0.801811165865399 0.274791531554279 no 929 0.211331099347168 228 83173
SGTC_2485 5633444 17.78 µM 0.800779728260087 0.27505542218875 no 930 0.211629588351455 240 5724239
SGTC_1117 retinoic acid 1.10837 µM 0.799709720764961 0.275329312679729 no 931 0.211939499789304 236 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3049 9092223 49.47 µM 0.798773860803898 0.275568975325245 no 932 0.212210774929845 232 8623917
SGTC_2428 5615643 7.78 µM 0.796850673330122 0.276061802645222 no 933 0.212768880665658 250 2253075
SGTC_570 0987-0065 62.6 µM 0.793209713587467 0.276996002025012 no 934 0.213827824545602 229 3104428
SGTC_1905 st060207 84.5 µM 0.793153485622053 0.277010441151695 no 935 0.213844202024942 229 1948547
SGTC_2054 5233173 129 µM 0.793070301281254 0.277031803248291 no 936 0.213868432408086 181 6889
SGTC_674 0498-0004 451 µM 0.792725346054186 0.277120397838791 no 937 0.213968929884569 241 4231473
SGTC_516 3992-2719 87.3 µM 0.790726767759392 0.277633963873463 no 938 0.214551726160453 219 5350887 YDR037W KRS1
SGTC_300 r073-0011 5.04 µM 0.789310805263942 0.277998098822306 no 939 0.214965186411388 232 2735780
SGTC_1738 st035555 74 µM 0.789034990823527 0.278069055547717 no 940 0.215045777884912 238 5331140
SGTC_871 0574-0004 149 µM 0.788844608149951 0.278118039032834 no 941 0.215101416895289 245 9551173
SGTC_1075 aripiprazole 15.2 µM 0.788340372098859 0.278247794065002 no 942 0.215248819392127 234 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2082 5219693 150 µM 0.788286828641924 0.278261574132796 no 943 0.215264475105214 242 2834649
SGTC_1929 genistein trimethyl ether 50.5 µM 0.787434277567021 0.278481033462353 no 944 0.215513843786473 226 136420
SGTC_1082 camptothecin 424.86 nM 0.787067504807917 0.278575472161934 no 945 0.215621175262551 265 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3070 9117005 49.47 µM 0.786350671640975 0.278760091393215 no 946 0.215831037015643 228 8779016
SGTC_3219 9131112 49.47 µM 0.78607426669444 0.278831294949507 no 947 0.215911989585858 242 17612988 YMR079W SEC14
SGTC_2325 6158266 200 µM 0.785561690341367 0.278963361083992 no 948 0.216062157815478 239 3623240
SGTC_2972 9093619 59.92 µM 0.78367899854681 0.279448700661856 no 949 0.216614244297841 225 25236256
SGTC_1720 st037298 9.481 µM 0.782932468479715 0.279641262312299 no 950 0.216833384872067 240 597396
SGTC_3331 9141060 1.957 µM 0.780578810982315 0.280248791308645 no 951 0.217525129059558 230 4906567 YPR165W RHO1
SGTC_2101 5377231 179.231 µM 0.780158651733408 0.280357310552577 no 952 0.217648748471712 247 2844213
SGTC_1817 st052116 64.4 µM 0.776968808435151 0.281181850170134 no 953 0.218588586575756 233 4361398
SGTC_1511 0906-3109 28.5 µM 0.776537940068523 0.281293314646025 no 954 0.218715714161092 243 2882180
SGTC_3186 9110464 49.47 µM 0.774137480490715 0.281914697173988 no 955 0.219424747520872 233 17018021
SGTC_1341 1486-1360 280 µM 0.77365030607528 0.282040887732492 no 956 0.219568807219193 264 3976547
SGTC_76 0433-0009 400.328 µM 0.773528155883939 0.282072532002028 no 957 0.219604936104108 234 2841569
SGTC_2505 galangin 7.89 µM 0.772572770862176 0.282320093325587 no 958 0.219887632174807 254 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_776 4476-4378 112 µM 0.770959379470775 0.282738395778944 no 959 0.220365504541882 272 2892008
SGTC_48 0382-0018 55 µM 0.770703895051528 0.28280466228253 no 960 0.220441231346327 222 762596
SGTC_2625 euphol 100 µM 0.769394382240098 0.283144435428566 no 961 0.220829611270715 251 6708538 A triterpene alcohol.
SGTC_1903 st060211 78.3 µM 0.768843158714331 0.283287517365269 no 962 0.220993212186173 232 688960
SGTC_482 fipronil 114 µM 0.768783557342074 0.283302990262115 no 963 0.221010905787641 243 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3039 9090270 49.47 µM 0.768229593130247 0.283446822295058 no 964 0.221175397529674 225 17173750
SGTC_3274 9138298 49.47 µM 0.768064521946448 0.283489688373256 no 965 0.221224426596029 262 17015756
SGTC_1157 4092-0394 27.6 µM 0.764743772125241 0.284352687858796 no 966 0.222212067826828 251 3659885
SGTC_412 gemfibrozil 100 µM 0.763869913694011 0.284579995469846 no 967 0.222472384109374 231 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3303 9125618 40.5795 µM 0.759852877751926 0.285626019518509 no 968 0.223671265676008 234 22695467
SGTC_1836 st055642 81 µM 0.759181489943388 0.285801025170015 no 969 0.223871998584048 268 8571
SGTC_2943 9068529 45.32 µM 0.758179943537382 0.286062185537222 no 970 0.224171633181748 274 3270634
SGTC_780 0109-0199 192 µM 0.758093530325218 0.286084723711346 no 971 0.224197496259789 259 610414
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.75733750362657 0.286281945518104 no 972 0.224423843831444 214 4000243
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.756319980485482 0.286547484771717 no 973 0.224728685717589 241 4330530
SGTC_529 4076-0302 30.3 µM 0.755557145294483 0.286746635653641 no 974 0.224957379041153 257 5816522
SGTC_325 2810-4341 181 µM 0.755000905250307 0.286891892771866 no 975 0.225124219529015 245 774970
SGTC_997 3996-0078 137 µM 0.754763695429628 0.286953848600307 no 976 0.225195390348157 244 735687
SGTC_2372 9071633 200 µM 0.754237782663246 0.287091232128214 no 977 0.225353227076659 239 21321366
SGTC_1732 st034308 51.822 µM 0.753958625756283 0.287164168585898 no 978 0.225437032978179 234 830119
SGTC_2327 6189656 200 µM 0.752282592864777 0.28760225682742 no 979 0.225940566856686 258 5349088
SGTC_2961 9083290 32.55 µM 0.747333783249775 0.288897636825036 no 980 0.227431052387465 256 17741490
SGTC_1866 st057638 64 µM 0.746549428107431 0.289103198204071 no 981 0.227667792384448 237 688802
SGTC_2070 5230947 200 µM 0.743212638832148 0.289978461488254 no 982 0.22867647630591 273 2835538
SGTC_2639 lactacystin 53 µM 0.738284417163612 0.291273436433577 no 983 0.230170816885864 248 3870 A proteasome inhibitor.
SGTC_3255 9139072 49.47 µM 0.737402863373436 0.291505364153117 no 984 0.230438697350749 263 17646060
SGTC_672 1441-0018 53.7 µM 0.736656726509021 0.291701732349293 no 985 0.230665564373875 251 251141
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.736050658677057 0.291861282560712 no 986 0.230849934444885 270 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_131 0141-0277 33.849 µM 0.733999334485036 0.2924016047226 no 987 0.231474571846719 260 1547771
SGTC_289 k017-0060 526 µM 0.732145509338592 0.292890305005032 no 988 0.232039879579594 258 5512909
SGTC_2379 9035213 200 µM 0.728783786215466 0.293777478904789 no 989 0.233066965535057 251 646551
SGTC_2930 9013230 14.89 µM 0.728385628810397 0.293882636741162 no 990 0.233188779017556 244 2995857
SGTC_1031 k035-0009 16 µM 0.727878513235752 0.294016596854803 no 991 0.233343978650211 267 5180959
SGTC_910 3454-3003 490 µM 0.727597011317804 0.294090970841174 no 992 0.233430155329639 272 820824
SGTC_1488 4013-0813 75.9 µM 0.72674498110112 0.294316133765949 no 993 0.233691096404618 251 2910057
SGTC_2922 7999257 32.47 µM 0.725553108499457 0.294631239107561 no 994 0.234056388094684 283 2988377
SGTC_3194 9111903 49.47 µM 0.723616784066945 0.295143492930952 no 995 0.234650517145467 265 17087251
SGTC_1433 4060-0023 7.6 µM 0.72284698354018 0.295347257205062 no 996 0.234886949159918 261 3840627
SGTC_937 3122-0005 46.7 µM 0.722334878825559 0.295482845885445 no 997 0.235044306891661 264 759535
SGTC_2402 5553605 200 µM 0.721859101452263 0.295608841914214 no 998 0.235190554257174 269 6758546
SGTC_2712 st079126 47.7 µM 0.720917314671309 0.295858320007905 no 999 0.235480194577214 259 3152970
SGTC_33 0986-0033 35.816 µM 0.720642844086462 0.295931045102722 no 1000 0.235564643222377 229 2848082
SGTC_485 niflumic acid 177 µM 0.720249964739867 0.296035158655109 no 1001 0.235685552744096 261 4488 A COX2 inhibitor.
SGTC_1747 st037496 66.6 µM 0.719111249848989 0.296337014565962 no 1002 0.23603618815537 275 723305
SGTC_633 0437-0093 97.7 µM 0.718133386031587 0.296596343890313 no 1003 0.236337523228068 263 2831118
SGTC_277 nystatin 15.5 µM 0.716661484834252 0.296986887730117 no 1004 0.236791498195389 282 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1109 tnp00067 928.257 nM 0.716480576716958 0.297034904837474 no 1005 0.236847328326525 257 676295
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.715182935207421 0.297379432281889 no 1006 0.237248006102653 299 6708760
SGTC_3020 9089140 49.47 µM 0.714499507181685 0.297560957686613 no 1007 0.237459180394377 257 17217859
SGTC_400 oxethazaine 37.5 µM 0.713201664356075 0.297905817044447 no 1008 0.237860488270354 261 4621 A local anesthetic.
SGTC_1791 st048313 56.1 µM 0.709846761060333 0.29879811627131 no 1009 0.238899583983891 242 1204976
SGTC_1856 st057054 55.7 µM 0.70967708181716 0.298843277888795 no 1010 0.238952203670695 274 1266018
SGTC_3095 9117207 49.47 µM 0.709542235582981 0.298879170607392 no 1011 0.238994025718326 240 17015229
SGTC_1456 k015-0012 13 µM 0.708286530105462 0.299213502214114 no 1012 0.239383670091755 272 2989616
SGTC_154 3389-1638 511.116 µM 0.707565209617125 0.299405630516537 no 1013 0.239607652044658 290 5238686
SGTC_2236 dapsone 200 µM 0.707354067879119 0.299461880044363 no 1014 0.239673236686331 256 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_685 1278-0033 54.9 µM 0.706645433334793 0.299650699893767 no 1015 0.239893423661823 278 3590572
SGTC_1468 k284-1086 134 µM 0.706339032911024 0.29973235879145 no 1016 0.239988662578609 265 15996457
SGTC_1670 st016595 4.04 µM 0.706276708951184 0.299748970008011 no 1017 0.240008037354387 288 597879
SGTC_1970 st070122 35.8 µM 0.70430308660421 0.300275215434616 no 1018 0.240622022265663 283 102928
SGTC_2926 9010726 65.15 µM 0.704011631161198 0.300352964307403 no 1019 0.240712765127438 274 2994293
SGTC_2715 st079500 56.4 µM 0.703763967846892 0.300419038307528 no 1020 0.240789888213706 274 28246688
SGTC_668 1682-0499 62.6 µM 0.703005458556939 0.300621441549879 no 1021 0.241026173868278 278 682214
SGTC_311 1315-0136 58 µM 0.702991699436287 0.30062511364964 no 1022 0.241030461179965 258 6759207
SGTC_2563 tomatine 8.54 µM 0.702273599127354 0.300816791785093 no 1023 0.241254277205838 290 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_835 0312-0010 67.2 µM 0.70133596888136 0.301067150662633 no 1024 0.241546685808419 277 1626196
SGTC_758 0868-0029 16 µM 0.700067964781083 0.301405872734348 no 1025 0.241942430457686 246 762687
SGTC_449 xestospongin c 11.1929 µM 0.698158267694094 0.301916333772002 no 1026 0.242539110919182 278 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_390 dec-rvkr-cmk 16.7 µM 0.696170700425204 0.302448021570628 no 1027 0.243160967143384 260 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2636 apigenin dimethyl ether 100 µM 0.695740568970229 0.30256313990746 no 1028 0.243295657058487 281 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_95 0471-0001 561.058 µM 0.695058710870021 0.302745669396633 no 1029 0.243509254408173 262 4015405
SGTC_136 0097-0015 404.482 µM 0.695004772260743 0.302760110556812 no 1030 0.243526155419137 274 4861337
SGTC_1507 4075-3230 155 µM 0.694905221400728 0.30278676444413 no 1031 0.243557350141088 268 659771
SGTC_3122 9126309 49.47 µM 0.693488397012927 0.303166220845123 no 1032 0.244001552453894 300 17591206
SGTC_974 1326-0144 138 µM 0.689769613013677 0.304163202209586 no 1033 0.245169540393703 282 5411856
SGTC_366 0181-0206 4.31 µM 0.688480531390715 0.304509137083057 no 1034 0.245575113064982 279 274874
SGTC_2184 6075246 200 µM 0.688363430157741 0.3045405707632 no 1035 0.245611973466841 274 2267320
SGTC_1462 k081-0014 26.5 µM 0.688105666696455 0.304609767726702 no 1036 0.245693121123443 247 3270634
SGTC_185 k048-0037 25.491 µM 0.687906345662398 0.304663280532688 no 1037 0.245755880129778 254 6827589
SGTC_2518 prenyletin 46.28 µM 0.685923567907099 0.305195835169911 no 1038 0.246380653732585 248 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2097 5376186 200 µM 0.683332012225077 0.305892523731996 no 1039 0.247198535131068 263 742755
SGTC_2964 9083345 53.42 µM 0.677983519619946 0.307332580847676 no 1040 0.248891071298955 275 17741579
SGTC_1736 st036774 51 µM 0.677959110832002 0.30733915963874 no 1041 0.248898809599872 281 1272247
SGTC_222 nsc-310342 10.666 µM 0.67749049064266 0.307465476753116 no 1042 0.249047400756403 278 432556
SGTC_908 3448-7491 47.7 µM 0.675321319614921 0.308050476640743 no 1043 0.249735820844579 241 1203031
SGTC_2761 levamisole 97.89 µM 0.67526162316039 0.308066582978655 no 1044 0.249754780717827 283 26879 An alkaline phosphatase inhibitor.
SGTC_1578 josamycin 24.2 µM 0.673028977933273 0.308669224654779 no 1045 0.250464427795208 271 5282165 A P450 substrate.
SGTC_2820 7989630 71.43 µM 0.672882837993852 0.308708689143329 no 1046 0.250510915659293 234 2984098
SGTC_1830 st055982 50.3 µM 0.67234267242062 0.308854577802896 no 1047 0.250682784771325 310 455313 An antimicrobial agent.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.671896632769239 0.308975067543424 no 1048 0.250824752092856 307 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2585 alliin 100 µM 0.670039090769872 0.309477070687523 no 1049 0.251416435578347 298 87310 A garlic compound which reacts with lipids.
SGTC_3129 9127257 49.47 µM 0.669924499487139 0.309508050789337 no 1050 0.251452960521384 289 837894
SGTC_1028 k015-0029 4.8 µM 0.66811493670307 0.309997450953886 no 1051 0.252030114008005 285 4588309
SGTC_1298 1079-1278 263 µM 0.6672130452181 0.310241495288425 no 1052 0.25231802980145 285 2840950
SGTC_614 0462-0418 107 µM 0.666804227321151 0.310352145550216 no 1053 0.252448596085251 264 5188303
SGTC_2939 9044578 71.43 µM 0.666436193368783 0.310451771952883 no 1054 0.252566167438036 289 2653634
SGTC_1579 chlormadinone acetate 49.4 µM 0.665078270517795 0.310819480510471 no 1055 0.253000216065998 292 45114258 A steroidal progestin.
SGTC_1115 galangin 695.678 nM 0.664142760435172 0.311072914952432 no 1056 0.25329947218776 300 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1897 st060201 15 µM 0.662655600956086 0.311475978449563 no 1057 0.253775575735725 283 611878
SGTC_1949 st076024 69.1 µM 0.662231842267801 0.311590870790372 no 1058 0.253911325033009 289 2921930
SGTC_1993 st073995 70.8 µM 0.662060831778286 0.311637241515016 no 1059 0.253966118308539 291 3098394
SGTC_1939 st074455 53.6 µM 0.659877282795853 0.312229588908494 no 1060 0.254666291774768 294 1644229
SGTC_2283 7944793 200 µM 0.657865198400379 0.312775851917312 no 1061 0.255312377496976 276 2970533
SGTC_3004 9076122 71.4286 µM 0.657582681752958 0.312852585640032 no 1062 0.255403162903538 295 44782551
SGTC_578 3460-0051 92 µM 0.65547297099976 0.313425855724552 no 1063 0.256081641613817 308 2876744
SGTC_2419 paclitaxel 166.5 µM 0.654840237013805 0.313597876027676 no 1064 0.256285310681595 297 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_729 4092-0585 94.1 µM 0.653523208308971 0.313956064350791 no 1065 0.256709516203576 282 2169061
SGTC_2276 7947513 42.08 µM 0.651231707392985 0.314579694806765 no 1066 0.257448462665038 288 2105100
SGTC_2137 5261020 140 µM 0.65085328025195 0.314682734478712 no 1067 0.257570601313147 282 763655
SGTC_3212 9128307 49.47 µM 0.649025231786118 0.31518068603851 no 1068 0.258161033703102 282 27243542
SGTC_310 1273-0058 1.06 µM 0.646704645265144 0.315813286525431 no 1069 0.258911558049498 261 2734232
SGTC_1987 st072290 61.9 µM 0.645852036818917 0.316045846469734 no 1070 0.259187592040193 298 54697379
SGTC_1925 st057770 10.1 µM 0.644010251301469 0.316548465643427 no 1071 0.259784393242782 278 5989122
SGTC_2298 7976326 193.81 µM 0.642466833063458 0.316969922155695 no 1072 0.260285058820303 269 2235818
SGTC_817 1391-0715 46 µM 0.6420016305253 0.317097000216908 no 1073 0.260436062157006 312 1353946
SGTC_45 0kpi-0036 14.9 µM 0.640571150796286 0.317487895426016 no 1074 0.26090067406052 299 2795021
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.639824036961972 0.317692133932706 no 1075 0.261143501856992 302 2346 DNA damaging agent; causes G2/M arrest.
SGTC_880 0833-0487 87.2 µM 0.63893453285744 0.317935370026906 no 1076 0.261432760901335 300 76075
SGTC_2067 5224629 34.075 µM 0.637930943007555 0.318209897351816 no 1077 0.26175931706858 288 2835000
SGTC_2975 9084847 53.72 µM 0.634183987463148 0.319235741262092 no 1078 0.2629803781558 273 27211724
SGTC_2508 celastrol 40.54 µM 0.633675850865742 0.319374966089108 no 1079 0.263146194065143 262 122724 Celastrol is a natural product and antioxidant.
SGTC_2232 chlorophetanol 41.5365 µM 0.633387557051646 0.319453967309979 no 1080 0.263240294286852 292 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2088 5278280 127.392 µM 0.631813083970935 0.319885565061674 no 1081 0.263754511497727 297 791502
SGTC_1436 4092-1007 8.32 µM 0.63113867069095 0.320070511255582 no 1082 0.263974929038815 270 2881121
SGTC_2153 5569715 200 µM 0.631039044362365 0.320097835847688 no 1083 0.264007497727804 295 2054701
SGTC_3273 9137859 49.47 µM 0.630617046851355 0.320213588258783 no 1084 0.264145474984732 328 2377234
SGTC_872 0588-0139 234 µM 0.627607479994624 0.321039608544851 no 1085 0.265130553712594 281 2047100
SGTC_1142 3253-1408 9.78 µM 0.627576892750263 0.321048008224826 no 1086 0.265140574969842 298 256655
SGTC_1388 3346-4487 254 µM 0.627281318213919 0.321129181794361 no 1087 0.265237423563263 319 3345614
SGTC_3012 9080433 71.4286 µM 0.625870470084621 0.321516760422768 no 1088 0.265699952468835 310 17688859
SGTC_1262 0737-0114 49.6 µM 0.625508408593374 0.3216162548586 no 1089 0.265818715703788 293 765919
SGTC_1415 3966-0071 78.1 µM 0.62337060609765 0.32220398325682 no 1090 0.266520504648821 300 2893185
SGTC_652 0437-0092 114 µM 0.623004088084584 0.32230479173886 no 1091 0.266640917696639 282 3091274
SGTC_3015 9080845 49.47 µM 0.622792997462138 0.322362856823391 no 1092 0.266710280288492 286 5296973
SGTC_378 3970-0959 8.33 µM 0.62230958473947 0.322495846373717 no 1093 0.266869159969551 314 6615653
SGTC_1172 0370-0043 85 µM 0.62213877151573 0.322542843481551 no 1094 0.266925311318384 293 376585
SGTC_2940 9060638 45.86 µM 0.621389980023042 0.322748897485467 no 1095 0.267171531589619 293 4027022
SGTC_171 k064-0041 9.68 µM 0.621072960963655 0.322836151856923 no 1096 0.267275809452059 286 53325
SGTC_1390 3413-2614 145 µM 0.619527992663758 0.323261518925446 no 1097 0.267784293445039 324 3421432
SGTC_371 0195-0006 7.36 µM 0.61932591503194 0.323317172882269 no 1098 0.26785083778752 285 3928593
SGTC_1290 0986-0249 10.2 µM 0.618793047258486 0.323463948310464 no 1099 0.268026351548937 311 53329
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.617531609369093 0.323811513743019 no 1100 0.268442069332485 310 364106
SGTC_1931 st074438 57.1 µM 0.616815580335015 0.324008870450425 no 1101 0.268678187064949 319 2787313
SGTC_2525 harmine 47.85 µM 0.615902255839891 0.324260678851654 no 1102 0.26897951631505 282 5280953 A monoamine oxidase inhibitor
SGTC_1760 st045453 10.4495 µM 0.615531599131007 0.324362893811688 no 1103 0.269101853876018 314 3323419 YIL048W NEO1
SGTC_1851 st056236 18.9 µM 0.614627088166055 0.32461238380805 no 1104 0.269400510522357 277 5393171
SGTC_1981 st071826 47 µM 0.614543002820748 0.3246355809523 no 1105 0.269428282746124 286 11838600
SGTC_2868 9035608 32.47 µM 0.612893620147689 0.325090743800336 no 1106 0.26997334099769 297 6462614
SGTC_2252 omeprazole 400 µM 0.612173558929395 0.325289533477583 no 1107 0.270211466769708 283 4594 A proton pump inhibitor.
SGTC_2711 st079103 59.1 µM 0.610473090832191 0.325759184612531 no 1108 0.270774231767881 308 54693780
SGTC_806 3966-4455 5.86 µM 0.609736542984371 0.325962697182064 no 1109 0.271018171625338 294 714982
SGTC_2594 a-mangostin 100 µM 0.60722497496444 0.326657048033952 no 1110 0.271850810005508 309 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1414 3917-0015 5.4 µM 0.605230828281321 0.327208780109513 no 1111 0.272512817407881 310 6618702
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.604021296129712 0.327543612495963 no 1112 0.272914741804505 300 4213774
SGTC_2127 5253358 187.912 µM 0.602259903063807 0.32803146355859 no 1113 0.273500573408321 305 20612
SGTC_2827 7993847 71.43 µM 0.601726293719601 0.328179314711429 no 1114 0.273678172305339 281 2985692
SGTC_2242 6630449 61.2675 µM 0.600690763762152 0.328466313582485 no 1115 0.274022985981342 305 691249 YDR170C SEC7
SGTC_2197 6588183 93.1375 µM 0.59889751902711 0.328963553767884 no 1116 0.27462061299358 300 884136
SGTC_2866 9034245 58.44 µM 0.597555685186851 0.329335822543362 no 1117 0.275068220335761 303 6462273
SGTC_3226 9131256 49.47 µM 0.595139756225287 0.330006507079707 no 1118 0.275875027885272 274 17178073
SGTC_1167 k781-0610 148 µM 0.593141287040346 0.330561714204937 no 1119 0.276543300795496 297 4525169
SGTC_2777 climbazole 1.536 µM 0.592949684721133 0.330614964052252 no 1120 0.276607412821633 299 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_17 0960-0276 49.807 µM 0.592026482503682 0.330871587161125 no 1121 0.276916427468552 295 6821114
SGTC_1933 st074711 15.9 µM 0.591847681428897 0.330921297802675 no 1122 0.276976295375552 302 17250958
SGTC_2710 st078562 53.7235 µM 0.591209575024149 0.33109872975404 no 1123 0.27719000398409 329 17250908
SGTC_1255 0566-0045 221 µM 0.591186767419796 0.331105072341935 no 1124 0.277197643985843 303 2788469
SGTC_2874 9043904 71.43 µM 0.590006750552243 0.331433290410701 no 1125 0.277593061883756 302 4463428
SGTC_60 0986-0278 202 µM 0.588737677858373 0.33178642361785 no 1126 0.278018629297654 340 3110598
SGTC_2664 lyso-paf C-16 73.48 µM 0.5859401922859 0.332565381945517 no 1127 0.278957853317703 322 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1480 1070-0044 41.2 µM 0.585561527149064 0.332670876716498 no 1128 0.2790851043412 302 3124987
SGTC_948 3448-0295 75.3 µM 0.585302344355397 0.332743091768009 no 1129 0.279172219400804 307 678569
SGTC_3213 9129884 49.47 µM 0.584443848748575 0.332982335229625 no 1130 0.279460866473504 303 17190742
SGTC_180 1486-1293 102.781 µM 0.582216494332657 0.333603365814009 no 1131 0.280210432258478 307 4140536
SGTC_742 0kpi-0133 140 µM 0.581454004721545 0.333816067949609 no 1132 0.280467254506995 310 2728852
SGTC_1228 0124-0032 52.5 µM 0.579472663019215 0.334369027498646 no 1133 0.28113514353834 306 X1228
SGTC_3036 9090181 49.47 µM 0.579121058994948 0.334467191940299 no 1134 0.281253745692319 322 25236586
SGTC_2720 fluspirilene 36.88 µM 0.577356010105103 0.334960147424299 no 1135 0.281849492136658 309 3396 An atypical antipsychotic.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.577320980412008 0.334969933649258 no 1136 0.281861321651587 312 5106787 A p450 inhibitor.
SGTC_96 0929-0093 37.281 µM 0.572518164881788 0.336312751817393 no 1137 0.283485491593974 312 6991579
SGTC_911 3456-4043 236 µM 0.571306315324911 0.336651903600477 no 1138 0.283896010773997 322 914281
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.571129552504873 0.336701384076588 no 1139 0.283955913699044 315 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_387 norethindrone acetate 66.7 µM 0.568957854433988 0.337309528927445 no 1140 0.284692370871322 322 541197
SGTC_1781 st038725 66.3 µM 0.56791625116157 0.337601362137096 no 1141 0.285045918251463 311 4270275 YIL048W NEO1
SGTC_1303 1160-0052 261 µM 0.563704606266947 0.338782362407281 no 1142 0.286477591016519 314 3562476
SGTC_72 0744-0168 198.391 µM 0.560683571872644 0.339630478005488 no 1143 0.287506634174072 358 677577
SGTC_2839 9003951 25.97 µM 0.5602922606168 0.339740393023685 no 1144 0.287640052754099 301 2990634
SGTC_478 N-arachidonylglycine 10 µM 0.55996861029582 0.339831313129228 no 1145 0.287750424269533 284 5283389
SGTC_92 0063-0024 660.874 µM 0.556382444197312 0.340839364383659 no 1146 0.288974718856787 317 3594437
SGTC_2309 7664088 163.95 µM 0.555822335881696 0.340996910590224 no 1147 0.289166157376163 321 704922
SGTC_2125 5246583 200 µM 0.554934422099034 0.34124671811118 no 1148 0.289469758127062 336 835267
SGTC_1935 st074532 41.6 µM 0.553824080548547 0.341559201837093 no 1149 0.289849623232566 325 2829742
SGTC_2564 betulinic acid 100 µM 0.552132757637084 0.342035400011405 no 1150 0.290428700030448 328 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_43 0570-0105 72.5 µM 0.550941165080025 0.342371048258312 no 1151 0.290837003579439 315 1114046 YDL195W SEC31
SGTC_2740 felodipine 17.08 µM 0.54818382501597 0.343148214024636 no 1152 0.291782843678988 310 3333 L-type calcium channel blocker
SGTC_740 k014-0057 261 µM 0.547757601355828 0.343268405953064 no 1153 0.291929177395443 342 4012779
SGTC_3150 9097574 49.47 µM 0.547621008388542 0.343306927517623 no 1154 0.291976080559671 329 17217476
SGTC_2596 sinensetin 100 µM 0.547545035475434 0.343328353889546 no 1155 0.292002169585353 323 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.546496554783084 0.343624104593957 no 1156 0.292362327646982 336 279621
SGTC_1125 tnp00248 1.32998 µM 0.545854300144907 0.343805316186163 no 1157 0.292583047113673 340 24207736
SGTC_1190 1486-1332 13 µM 0.545835002645033 0.343810761514699 no 1158 0.292589680157662 333 4150046
SGTC_567 1080-0542 68.4 µM 0.538744591561598 0.345813703834397 no 1159 0.295031550295458 301 5950415
SGTC_799 1310-0557 151 µM 0.537497030469468 0.346166571263001 no 1160 0.295462167791196 350 5354492
SGTC_3120 9124077 49.47 µM 0.53745595182851 0.346178192458097 no 1161 0.295476351716169 344 18774327 YGL155W CDC43
SGTC_1512 0259-0544 12.2 µM 0.53743766590136 0.346183365614654 no 1162 0.295482665711725 316 18476
SGTC_1267 0828-0272 9.49 µM 0.536440122876704 0.346465617699866 no 1163 0.295827203932331 319 745334
SGTC_2314 7727897 200 µM 0.535809316825608 0.346644146576842 no 1164 0.296045171230936 304 900724
SGTC_1787 fluconazole 80 µM 0.535464931445017 0.346741627893797 no 1165 0.296164200476222 310 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1353 1498-1206 8.11 µM 0.53452673357122 0.347007244530224 no 1166 0.29648857930255 309 6756808
SGTC_98 0074-0023 107.663 µM 0.53408142218102 0.347133344591356 no 1167 0.296642601206815 321 3563821
SGTC_2773 thioridazine 9.09 µM 0.531155176191536 0.347962398306597 no 1168 0.297655625751021 324 5452 An antipsychotic.
SGTC_2676 harmalol 100 µM 0.528684781675619 0.348662868205482 no 1169 0.298512067951236 320 5459187 A monoamine oxidase inhibitor
SGTC_762 1165-0429 115 µM 0.52748797153492 0.349002404438468 no 1170 0.298927383626159 339 5967793
SGTC_1717 st033143 58.0435 µM 0.527486044352441 0.349002951279655 no 1171 0.298928052606421 353 674616
SGTC_949 1165-0505 146 µM 0.526496955864565 0.349283648116703 no 1172 0.299271483262416 307 6244267
SGTC_1210 3013-0140 750 nM 0.525916302340374 0.349448472208887 no 1173 0.299473180748943 329 905973
SGTC_1320 1313-0481 95.3 µM 0.524887761310153 0.349740503151736 no 1174 0.299830608908239 315 6813365 YLR208W SEC13
SGTC_1203 3992-3522 103 µM 0.524819550860989 0.349759873110801 no 1175 0.299854319540192 370 5322312
SGTC_2700 st077718 96.8 µM 0.523179276820218 0.350225785119504 no 1176 0.300424750587002 329 904970
SGTC_2157 5649910 96.377 µM 0.522245253241324 0.350491190868059 no 1177 0.300749790852127 328 2858091
SGTC_2133 5320837 200 µM 0.51606864404936 0.352248126143927 no 1178 0.302903233479142 341 2841355
SGTC_1417 3966-0327 90.4 µM 0.514807407683387 0.35260727407011 no 1179 0.303343804209372 337 651118
SGTC_2987 9018338 71.43 µM 0.514663800460218 0.352648175804552 no 1180 0.303393986744035 327 5055682
SGTC_818 4072-2707 53.5 µM 0.512724287641456 0.35320074812611 no 1181 0.304072098877016 331 882871
SGTC_3315 9136395 68.55 µM 0.51247368665552 0.353272167622275 no 1182 0.304159765792419 373 16876844
SGTC_2728 chlorpromazine 9.18 µM 0.511256170112204 0.353619224667527 no 1183 0.304585845745336 372 2726 A thorazine and dopamine antagonist.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.509862915715039 0.354016525684899 no 1184 0.305073752087706 352 6708784 An antioxidant flavonoid
SGTC_224 benfluorex 43.875 µM 0.50811373100003 0.354515549019529 no 1185 0.305686793136155 355 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2718 lomofungin 53.02 µM 0.507994018835853 0.354549710738826 no 1186 0.305728768896878 336 5351222 A RNA synthesis inhibitor.
SGTC_1284 0929-0043 16 µM 0.507182169590625 0.354781415349011 no 1187 0.306013502288386 335 1239883
SGTC_1246 0422-0085 105 µM 0.506102465797091 0.355089649819582 no 1188 0.306392359820199 378 264295
SGTC_1975 st070967 30.8 µM 0.505347320023572 0.355305285659038 no 1189 0.30665745619108 353 261391
SGTC_1334 1486-0610 236 µM 0.505257981424111 0.355330799831586 no 1190 0.306688825491512 320 3742339
SGTC_1169 aniline yellow 25.8 µM 0.504752983903831 0.35547503404778 no 1191 0.30686617097408 344 6051 A DNA damaging agent.
SGTC_1470 k295-0292 231 µM 0.503861935060559 0.355729580291293 no 1192 0.307179200550596 346 5045612
SGTC_39 0986-0283 58.349 µM 0.502994020476078 0.355977579625885 no 1193 0.307484238100603 309 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1164 k060-0068 93.7 µM 0.498346772542822 0.357306526495326 no 1194 0.309119823154718 329 5963676
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.496541720462577 0.357823174981887 no 1195 0.309756129867002 335 616764
SGTC_3155 9099265 49.47 µM 0.494537278878285 0.358397198766667 no 1196 0.310463392754503 366 25236499
SGTC_3269 9137823 49.47 µM 0.492047362619214 0.35911069653665 no 1197 0.311342930932931 329 17682936
SGTC_2222 6885208 172.143 µM 0.490615076325299 0.359521348177224 no 1198 0.31184936060933 334 609514
SGTC_500 h-89 112 µM 0.49057694613172 0.359532282726998 no 1199 0.31186284760172 363 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2730 imipramine 71.33 µM 0.488513189246682 0.36012427516415 no 1200 0.312593192931383 320 3696 A tricyclic antidepressant.
SGTC_8 0354-0001 70 µM 0.488254974750692 0.360198368114728 no 1201 0.312684624661808 351 4993152
SGTC_3158 9100007 49.47 µM 0.485459295516953 0.361000905576712 no 1202 0.313675289881751 329 19297233
SGTC_2385 9074692 200 µM 0.484324316874687 0.361326891471965 no 1203 0.314077860490218 330 17046906
SGTC_2432 5630864 12.22 µM 0.482981292095581 0.361712761972492 no 1204 0.314554509808396 355 5714970
SGTC_1316 1272-0050 65.9 µM 0.482909432972641 0.361733412108592 no 1205 0.314580021859466 344 7340392
SGTC_1752 st044819 83.042 µM 0.482776173554608 0.361771707896009 no 1206 0.314627335120668 332 441209 YML126C ERG13
SGTC_2811 7967822 32.47 µM 0.481574788834012 0.362117021551121 no 1207 0.315054019647717 322 2232244
SGTC_3142 9086498 49.47 µM 0.481395249615276 0.362168636103737 no 1208 0.315117806125872 342 25236367
SGTC_199 4063-0024 41.6 µM 0.478882629773996 0.362891235286198 no 1209 0.316011064447453 349 306215
SGTC_528 3492-0019 172 µM 0.477286576370087 0.363350494870903 no 1210 0.316579034208444 355 2869262
SGTC_957 1187-1561 14.1 µM 0.476956200592038 0.363445584079554 no 1211 0.316696655466108 337 1538454
SGTC_414 piperonyl butoxide 100 µM 0.476637190332423 0.363537410034551 no 1212 0.316810247932054 354 5794 A potent inhibitor of cytochrome P450.
SGTC_3105 9121040 49.47 µM 0.474658366308595 0.364107182384542 no 1213 0.317515248745 319 41448907
SGTC_1706 st031321 9.9705 µM 0.473765635134407 0.36436432922573 no 1214 0.317833521402538 331 6103185
SGTC_3254 9136651 49.47 µM 0.473199454187541 0.36452744652418 no 1215 0.318035443570817 360 16454030
SGTC_3283 9109332 35.8195 µM 0.472307895955576 0.36478435506831 no 1216 0.318353517607897 321 17027281
SGTC_830 4076-0286 57.8 µM 0.467442663501125 0.366187371912886 no 1217 0.320091602385532 344 6866659
SGTC_3336 9143619 71.43 µM 0.466790834545282 0.366375480262171 no 1218 0.320324766979066 333 45595730
SGTC_2823 7987624 58.44 µM 0.466753115790904 0.366386366328909 no 1219 0.320338261461087 361 2239440
SGTC_2005 4024620 188 µM 0.466269495060502 0.366525954363189 no 1220 0.320511305486587 363 236743
SGTC_565 1418-0001 44.5 µM 0.466144487292698 0.366562038378609 no 1221 0.320556040785051 357 2862145
SGTC_141 0443-0274 32.331 µM 0.466013844905317 0.366599750110999 no 1222 0.320602795275088 325 1627241
SGTC_1515 3460-0031 42.1 µM 0.463599956528537 0.367296783776781 no 1223 0.321467192755364 344 2876596
SGTC_1667 st014849 34.6 µM 0.463361125205667 0.367365772459555 no 1224 0.321552769356945 333 5348460
SGTC_2017 5132927 60.65 µM 0.462950909462585 0.36748427714171 no 1225 0.321699777493658 346 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1565 sinapyl alcohol 95.1 µM 0.460292002749095 0.368252697768898 no 1226 0.322653320338146 366 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1454 4239-0054 42.6 µM 0.459961450852518 0.36834826375865 no 1227 0.322771945287769 370 1340767
SGTC_3127 9126946 49.47 µM 0.454582080799161 0.369904636577106 no 1228 0.324704964339326 379 27243249
SGTC_211 3455-0679 143.504 µM 0.453493826185677 0.370219753381377 no 1229 0.325096593986582 338 748649
SGTC_2702 st077768 96.8 µM 0.452272688191055 0.370573451845753 no 1230 0.32553627446624 316 6484119
SGTC_1811 st050069 61.5 µM 0.451890746053783 0.370684102565408 no 1231 0.325673845672464 368 3877702
SGTC_2958 9077254 16.72 µM 0.451048779842955 0.370928062537089 no 1232 0.325977196157594 331 16457351
SGTC_2984 9022109 38.96 µM 0.449553202787135 0.371361534349043 no 1233 0.326516318919153 372 6459207
SGTC_3101 9120531 49.47 µM 0.448510654484259 0.371663798775215 no 1234 0.326892349277519 391 24824904
SGTC_3227 9130768 49.47 µM 0.445534856455029 0.372527002080395 no 1235 0.327966637955589 370 17720899
SGTC_293 4049-0273 38.5 µM 0.444440482431144 0.372844613513971 no 1236 0.328362075249167 345 1380311
SGTC_2878 9043973 25.97 µM 0.441669086765378 0.373649319811984 no 1237 0.329364341295055 364 6465167
SGTC_2814 7977482 42.97 µM 0.438723524140083 0.374505201680471 no 1238 0.330430939807769 360 6456762
SGTC_1148 3909-7663 27.7 µM 0.43802221165571 0.374709070953374 no 1239 0.330685091072889 368 4084526
SGTC_3069 9117009 49.47 µM 0.437765231921512 0.374783782902648 no 1240 0.330778238477604 331 41904981
SGTC_2450 5739737 12.93 µM 0.437068752167902 0.374986294711442 no 1241 0.331030744061276 359 2262825
SGTC_1276 0871-0068 94.2 µM 0.437029737559614 0.374997639806992 no 1242 0.331044890905738 365 3414906
SGTC_333 3486-0131 40.1 µM 0.436063884941985 0.375278535480317 no 1243 0.331395189574164 372 6744690
SGTC_3223 9129970 49.47 µM 0.435990497293018 0.375299881269601 no 1244 0.331421812088521 363 17248386
SGTC_2407 paclitaxel 400 µM 0.433241369854346 0.376099776662899 no 1245 0.332419713566321 412 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1557 sumaresinolic acid 42.3 µM 0.433073699258655 0.376148579930705 no 1246 0.33248061459438 348 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2031 5180455 200 µM 0.432139456115661 0.376420542911444 no 1247 0.332820029727769 355 29949
SGTC_3137 9097352 49.47 µM 0.431923815702093 0.376483325665221 no 1248 0.332898392429149 391 44120435
SGTC_209 4077-0173 175.592 µM 0.431809325853208 0.376516660207055 no 1249 0.332940000462662 332 15993494
SGTC_2259 7964009 200 µM 0.430970920839543 0.376760795897219 no 1250 0.333244757243097 327 313134
SGTC_1051 3253-3903 78 µM 0.430663300264157 0.376850384494309 no 1251 0.333356603687413 366 5509239
SGTC_57 miconazole 162.5 nM 0.429250161040518 0.377262019343844 no 1252 0.33387059117 368 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3031 9088762 49.47 µM 0.428651469945431 0.377436454815581 no 1253 0.334088441402024 359 205253
SGTC_125 0133-0007 11.75 µM 0.428231805227458 0.377558743822521 no 1254 0.334241181297377 374 26541
SGTC_660 4031-1742 102 µM 0.426878855345815 0.377953072776404 no 1255 0.33473378362425 367 6738706
SGTC_2091 4-phenylthiadiazole 200 µM 0.425080104361714 0.378477531234359 no 1256 0.335389140478628 354 270010
SGTC_129 0088-0017 176.636 µM 0.424327982162219 0.378696892543426 no 1257 0.335663317372286 371 182446
SGTC_1838 st055369 84.5 µM 0.422439497963912 0.379247853323501 no 1258 0.3363521265133 325 676036
SGTC_3040 9091894 49.47 µM 0.421497467478363 0.379522780275462 no 1259 0.336695930047541 351 25236966
SGTC_214 4373-3496 70 µM 0.419684883414108 0.380051945284705 no 1260 0.337357834789735 372 3779166
SGTC_231 b-estradiol 524 µM 0.419167117184762 0.380203143024441 no 1261 0.337547001032241 346 450 A steroid.
SGTC_1473 k844-0725 134 µM 0.418065149997562 0.380524999649654 no 1262 0.337949742124696 367 54682906
SGTC_2024 5144227 134 µM 0.417738309646356 0.380620477330157 no 1263 0.338069229696496 364 3475211
SGTC_759 3486-0358 89.3 µM 0.41719326412338 0.380779713996221 no 1264 0.338268525851502 382 875103
SGTC_2864 9034755 47.6 µM 0.415027022253527 0.381412787388202 no 1265 0.339061060771142 345 4930451
SGTC_3050 9093513 49.47 µM 0.41371061640844 0.381797655607461 no 1266 0.339543025582082 367 25236664
SGTC_563 tetrahydrosecaminediol 614 µM 0.412744522183973 0.382080180087546 no 1267 0.339896900776505 365 334274 A psychoactive constituent of the cannabis plant.
SGTC_703 3875-0075 71.8 µM 0.411515210222187 0.382439770717086 no 1268 0.340347395251319 380 2850814
SGTC_602 3130-1533 38.1 µM 0.408811892355695 0.383230884573876 no 1269 0.341338855922457 391 720941
SGTC_888 0916-0002 6.97 µM 0.405640672624085 0.384159548643777 no 1270 0.342503319790448 353 2802138 YIL048W NEO1
SGTC_1702 st027038 51 µM 0.403049844817384 0.384918744178978 no 1271 0.343455778168848 365 5521182
SGTC_803 4488-1585 147 µM 0.402480495572117 0.385085641007247 no 1272 0.343665219906329 396 747204
SGTC_2285 7945142 200 µM 0.402282302663779 0.385143743504324 no 1273 0.343738138736801 382 2970608
SGTC_2667 digitoxin 100 µM 0.402241664175165 0.385155657456412 no 1274 0.34375309110549 353 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_681 1642-0006 26.6 µM 0.401533878806087 0.385363175684059 no 1275 0.344013550104552 407 4446530
SGTC_895 0964-0006 13.7 µM 0.401445205572354 0.385389176434758 no 1276 0.344046186321542 385 6738897
SGTC_1253 0550-0034 176 µM 0.40112603644242 0.385482767416729 no 1277 0.344163666254843 353 5969915
SGTC_2312 7706453 155.7 µM 0.399571865217085 0.385938597208161 no 1278 0.344735941142941 368 976098
SGTC_3024 9090631 49.47 µM 0.39892556141532 0.386128200935751 no 1279 0.344974027001586 365 25236383
SGTC_2463 5473429 200 µM 0.398702600048801 0.386193616589892 no 1280 0.345056175916985 387 5399405
SGTC_3232 9132874 49.47 µM 0.39560327654882 0.387103275563688 no 1281 0.346198859782377 370 3784940
SGTC_1520 flindersine 88 µM 0.394193144697538 0.387517358336889 no 1282 0.34671922327364 388 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2903 5923464 63.88 µM 0.393613981033357 0.387687465848172 no 1283 0.346933028736853 382 2876576
SGTC_3175 9106517 49.47 µM 0.393203879547373 0.387807930752818 no 1284 0.347084452278736 393 41468073
SGTC_2180 6301957 200 µM 0.392281330546789 0.388078963562438 no 1285 0.347425178250229 382 845462
SGTC_1371 2421-0008 32.7 µM 0.389639107485412 0.3888555153622 no 1286 0.348401714805339 390 2827552
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.389190604299782 0.388987375055737 no 1287 0.348567576666298 392 5282309
SGTC_2387 9077560 195.08 µM 0.389132031014356 0.389004596514319 no 1288 0.348589239908437 363 5303272
SGTC_671 0560-0003 407 µM 0.38808751747155 0.389311736359858 no 1289 0.348975634535306 401 3238678
SGTC_1471 k673-0312 37 µM 0.387430961957586 0.389504832324179 no 1290 0.349218592899575 370 24099884
SGTC_1055 3448-0672 86 µM 0.38698072873243 0.389637263737106 no 1291 0.349385237433237 373 748378
SGTC_2415 st077333 57.7 µM 0.386516313575266 0.389773880044905 no 1292 0.34955716153959 431 2766255
SGTC_3169 9102970 49.47 µM 0.386050971985448 0.389910782540473 no 1293 0.349729459562787 378 17027839
SGTC_5 0352-0601 109.883 µM 0.385901328249969 0.389954810308861 no 1294 0.349784873439471 370 762456
SGTC_2841 9004761 38.96 µM 0.383630482550431 0.390623105253341 no 1295 0.350626171894981 342 2991039
SGTC_2847 9005661 71.43 µM 0.381331516076051 0.391300005237033 no 1296 0.3514786353697 386 2991449
SGTC_1351 1496-0003 46.5 µM 0.379052424362024 0.391971378481267 no 1297 0.352324467224007 369 3891978
SGTC_1977 st070720 65.3 µM 0.376983086847448 0.392581241273443 no 1298 0.353093086990909 362 682188
SGTC_1973 st070275 50.2 µM 0.374967211521479 0.393175601758877 no 1299 0.353842425964991 369 17118334
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.370314446260126 0.394548371398569 no 1300 0.355574105590092 429 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1221 2958-7315 257 µM 0.36943186772206 0.394808919141276 no 1301 0.355902924161006 378 4562705
SGTC_422 cantharidin 155 µM 0.366272734036334 0.395741918067382 no 1302 0.357080786583696 367 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2707 st078556 66.6 µM 0.364537050055691 0.396254778962508 no 1303 0.357728506147203 379 17250899
SGTC_3338 9144300 39.5675 µM 0.363856157004986 0.396456018725033 no 1304 0.357982712694124 362 4901274
SGTC_3208 9114115 49.47 µM 0.361003816974097 0.397299334714658 no 1305 0.359048296843074 403 650895
SGTC_666 0272-0154 136 µM 0.358464889641772 0.398050392078649 no 1306 0.35999771923501 383 6870312
SGTC_3215 9129942 49.47 µM 0.358138931120794 0.398146843518446 no 1307 0.360119672935736 421 17682944
SGTC_2850 9015429 58.44 µM 0.356196595677167 0.398721711296215 no 1308 0.360846670617673 400 6457570
SGTC_2443 5493264 126.67 µM 0.35518854102651 0.399020149228394 no 1309 0.361224174363856 404 5340055
SGTC_1751 st044839 27.194 µM 0.353999268674112 0.399372313165306 no 1310 0.361669715654796 358 5291326
SGTC_3115 9123671 49.47 µM 0.353972214840179 0.399380325223229 no 1311 0.361679853112471 379 3286988
SGTC_3055 9094636 49.47 µM 0.350354792790318 0.400452013849364 no 1312 0.363036224523143 387 25236176
SGTC_2870 9038528 12.99 µM 0.348811325217357 0.400909506499704 no 1313 0.363615480254114 395 6463316
SGTC_3237 9133362 49.47 µM 0.348697199271388 0.400943339489882 no 1314 0.363658323556382 427 43845137
SGTC_2483 5729050 27.16 µM 0.34744201069633 0.401315492997595 no 1315 0.364129638378767 417 2865180
SGTC_2423 st077119 87.2 µM 0.345540054999179 0.401879578392287 no 1316 0.364844201449705 362 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_497 capsazepine 133 µM 0.345514375054857 0.401887195997314 no 1317 0.364853852601346 367 2733484 A calcium channel blocker.
SGTC_2094 5332512 191.667 µM 0.345136362030816 0.40199933271326 no 1318 0.364995929053282 409 755774
SGTC_2713 st079149 53.4 µM 0.341328424240652 0.403129397404479 no 1319 0.366428175962224 388 3103253
SGTC_2144 5628481 200 µM 0.340279138282132 0.403440931981964 no 1320 0.366823163016311 380 2818399
SGTC_1482 3346-2049 8.48 µM 0.339806064229255 0.40358140843431 no 1321 0.367001290395796 390 3826804
SGTC_1849 st056239 19.2 µM 0.339631198858915 0.403633336788547 no 1322 0.367067140002586 423 5393181
SGTC_2343 7990716 14.84 µM 0.339404290619027 0.40370072242499 no 1323 0.367152593387501 388 6456862
SGTC_389 tpck 16.7 µM 0.339402621564871 0.403701218099719 no 1324 0.367153221975784 370 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_407 eburnamonine 100 µM 0.338665139867295 0.403920250104557 no 1325 0.367431002336391 377 3195
SGTC_971 1315-0384 26.7 µM 0.338323473044312 0.404021735340356 no 1326 0.367559718323282 412 6769120
SGTC_70 0141-0289 43.283 µM 0.334964746391516 0.405019720205037 no 1327 0.368825839900264 379 352408
SGTC_1947 st076332 61.6 µM 0.332307740306693 0.405809639675163 no 1328 0.36982844788599 434 24208416
SGTC_56 0957-0365 83.25 µM 0.329742904737467 0.406572521144923 no 1329 0.370797115942868 396 6752360
SGTC_576 1073-0113 22.7 µM 0.329422001187226 0.406667995320767 no 1330 0.370918370216756 424 5439563
SGTC_2240 6690706 185.951 µM 0.328930295170968 0.406814296849649 no 1331 0.371104187529132 366 805876
SGTC_961 1252-1571 372 µM 0.328766133944673 0.40686314405106 no 1332 0.371166231287967 420 6813498
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.32621376054744 0.407622804688555 no 1333 0.372131315477896 401 6708514
SGTC_1056 3448-1962 115 µM 0.325251016837063 0.407909435658984 no 1334 0.372495549972969 406 715507
SGTC_2487 5918373 44.05 µM 0.325152184447331 0.407938863129625 no 1335 0.372532947658122 445 2876279
SGTC_261 5-fluorouridine 15.376 µM 0.322991719963465 0.408582273680677 no 1336 0.373350756397254 375 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2626 ethyl orsellinate 100 µM 0.320879855363383 0.409211448897093 no 1337 0.374150720221934 394 75653 A natural product.
SGTC_2504 purpurogallin 52.29 µM 0.31879075011522 0.409834073763377 no 1338 0.374942596476583 393 5281571 An antioxidant.
SGTC_1261 0712-0010 12.7 µM 0.317987151188868 0.410073634400881 no 1339 0.375247341664374 418 2840123
SGTC_3314 9135860 59.4275 µM 0.317947270090877 0.410085524218151 no 1340 0.37526246762282 408 25252478
SGTC_1177 0983-0204 23.6 µM 0.316677529079191 0.410464117347954 no 1341 0.375744150544031 402 766818
SGTC_1815 st051655 58.2 µM 0.316377687481052 0.410553532000111 no 1342 0.37585792532958 399 5984156
SGTC_2381 9035592 200 µM 0.315523895964469 0.410808163457231 no 1343 0.376181955304359 402 4749657
SGTC_1616 st002734 56.1 µM 0.310047946224812 0.412442178673938 no 1344 0.378262247895185 408 4026101
SGTC_1072 oxiconazole 14.9 nM 0.309687120246147 0.412549902249308 no 1345 0.378399449073885 391 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2871 9038510 12.99 µM 0.309154563691584 0.412708907536444 no 1346 0.378601977433675 429 4945164
SGTC_1093 fluphenazine 7.97 µM 0.308638838258925 0.412862901212516 no 1347 0.378798136793154 429 6602611 An atypical antipsychotic.
SGTC_2154 5570129 200 µM 0.308091771350746 0.413026267992865 no 1348 0.379006251205593 432 673366
SGTC_1335 1486-0900 202 µM 0.307971367219009 0.413062225463457 no 1349 0.37905205988553 399 X1335
SGTC_2588 indole-3-carbinol 100 µM 0.30573533255898 0.413730126728447 no 1350 0.379903084560976 442 3712 Induces cell cycle arrest.
SGTC_2583 asiatic acid 100 µM 0.301649154485636 0.414951307617894 no 1351 0.381459766233421 452 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2277 7947813 106.88 µM 0.301364923125486 0.415036282730361 no 1352 0.381568119488679 434 1246798
SGTC_2895 9054447 58.44 µM 0.301235060489516 0.415075108383475 no 1353 0.381617628161813 400 2697450
SGTC_1980 st071811 45.7 µM 0.300343530097572 0.415341675860125 no 1354 0.381957566371238 426 4974850
SGTC_411 enrofloxacin 100 µM 0.300335037875841 0.415344215220941 no 1355 0.381960804871298 435 71188 A bacterial gyrase inhibitor.
SGTC_889 0919-1524 82.7 µM 0.299703930020451 0.415532940219742 no 1356 0.382201500306991 395 3905452
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.296313735176313 0.416547068503373 no 1357 0.383495248775368 444 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2060 5238662 140 µM 0.29596843957151 0.416650390038956 no 1358 0.38362709187364 397 790130
SGTC_2136 5328288 199.296 µM 0.294665788591509 0.4170402292895 no 1359 0.384124600047225 403 262395
SGTC_377 3970-0964 33.1 µM 0.293550040293446 0.417374199786772 no 1360 0.384550878281373 395 16481235
SGTC_1342 1486-1464 234 µM 0.292848203983417 0.417584306958439 no 1361 0.384819090569188 426 3253938
SGTC_1828 st055811 49 µM 0.292514158865996 0.417684317569522 no 1362 0.384946767920854 443 5877589
SGTC_2079 5212404 121 µM 0.291742418618063 0.417915391180187 no 1363 0.385241786992104 399 758462
SGTC_2373 9071805 200 µM 0.290631968880244 0.418247930520518 no 1364 0.385666403662675 424 10149009
SGTC_286 k060-0067 22.9 µM 0.290628349504979 0.418249014487561 no 1365 0.385667787873194 395 5985051
SGTC_3238 9133470 49.47 µM 0.29057657811251 0.418264519574776 no 1366 0.385687587721938 429 3534688
SGTC_774 k060-0086 136 µM 0.290188506866828 0.418380747621313 no 1367 0.385836014149208 437 5911235
SGTC_510 ag-490 170 µM 0.288491629305589 0.418889049132149 no 1368 0.386485218561336 416 5328779
SGTC_2552 juarezic acid 87.02 µM 0.287294126750472 0.4192478438846 no 1369 0.38694355968592 390 1549512
SGTC_3205 9113483 49.47 µM 0.286389062177686 0.419519063182534 no 1370 0.387290075576423 459 17018033
SGTC_854 0422-0053 192 µM 0.283090817530586 0.420507765702023 no 1371 0.388553610181111 416 3596728
SGTC_893 0958-0369 48.9 µM 0.282245276334783 0.420761311485436 no 1372 0.388877721721744 443 6819948
SGTC_1754 st042065 16.137 µM 0.281786190808882 0.420898987625308 no 1373 0.3890537300908 423 1126236 YIL048W NEO1
SGTC_2824 7998404 51.95 µM 0.280684515147554 0.421229410928293 no 1374 0.389476193309434 423 837851
SGTC_1429 4049-0205 9.46 µM 0.279823235392095 0.421487771441829 no 1375 0.389806562137748 403 22774478
SGTC_3307 9126885 69.2785 µM 0.279138606182192 0.421693165714806 no 1376 0.390069228344053 396 24824909
SGTC_3309 9129340 25.759 µM 0.278987518376976 0.421738496143993 no 1377 0.390127201758211 385 17158987
SGTC_592 k241-0073 46.5 µM 0.278480730363304 0.421890553828896 no 1378 0.390321677590168 432 4230158
SGTC_1659 st012954 42.1 µM 0.277033486554645 0.42232485178332 no 1379 0.390877196742179 415 24207262
SGTC_3 0833-0587 95.581 µM 0.276534689582363 0.422474555805723 no 1380 0.391068709779307 403 5382644
SGTC_978 1416-0512 87.4 µM 0.27492239800534 0.422958529656996 no 1381 0.391687929417712 413 6814003
SGTC_2194 5927483 104.545 µM 0.274606466444711 0.423053378891278 no 1382 0.391809298883086 360 760979
SGTC_3313 9133968 57.047 µM 0.273474681851094 0.423393200768706 no 1383 0.39224417589141 448 1494643
SGTC_640 3381-0960 37.1 µM 0.273160039799838 0.423487683167611 no 1384 0.392365097916919 422 1745025
SGTC_2116 5511452 16.8835 µM 0.272960254746679 0.423547677976489 no 1385 0.392441883937327 445 870744
SGTC_1096 rimcazole 32.2 µM 0.27180060649522 0.423895951576008 no 1386 0.392887669427259 446 18528119 A dopamine reuptake inhibitor.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.271383718896151 0.424021168690633 no 1387 0.393047961394494 403 688761
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.270494817554409 0.424288186308597 no 1388 0.393389801686462 405 688664
SGTC_634 1611-4317 11.2 µM 0.270267188076307 0.424356569661308 no 1389 0.393477353233811 434 2843522
SGTC_1293 1000-1278 195 µM 0.270191727307142 0.424379239725223 no 1390 0.393506378375064 437 678847
SGTC_1017 4239-0030 168 µM 0.270179840801377 0.424382810714091 no 1391 0.393510950440578 392 1149593
SGTC_314 1671-0008 2.74 µM 0.269345530323017 0.424633472904628 no 1392 0.393831899075958 429 3913060
SGTC_159 3970-0959 50 µM 0.269198866976844 0.424677539936196 no 1393 0.393888326061196 416 6615653
SGTC_3325 9138760 55.175 µM 0.268581624900744 0.424863009169886 no 1394 0.394125827043767 394 43844959
SGTC_353 1988-1175 58.3 µM 0.266622853689019 0.425451691765897 no 1395 0.394879778860151 426 2788357
SGTC_3284 9108171 64.8615 µM 0.265397655808347 0.42581999325928 no 1396 0.395351570914663 437 8687505
SGTC_432 NS 1619 61.3 µM 0.265278592240674 0.425855787904602 no 1397 0.395397427409323 391 4552 A K+/calcium channel activator.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.265215995748063 0.425874606830262 no 1398 0.395421536588607 423 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2053 5265679 138 µM 0.265205500885832 0.425877762008107 no 1399 0.395425578747474 420 764595
SGTC_1365 1672-3266 55.4 µM 0.261088546966724 0.427115848079141 no 1400 0.397012111825119 455 6415873
SGTC_1419 3993-2473 62.6 µM 0.260859933264137 0.427184619935976 no 1401 0.397100261954683 416 704026
SGTC_2497 7-hydroxyflavone 100 µM 0.256585786138102 0.428470779398868 no 1402 0.398749274377845 449 5281894
SGTC_2359 9039622 200 µM 0.252028801821526 0.429842886081689 no 1403 0.400509400784225 436 6463596
SGTC_2734 clemastine 41.6 µM 0.251768612030744 0.429921254895788 no 1404 0.400609959954595 455 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2855 9016525 58.44 µM 0.250746255649511 0.43022921397013 no 1405 0.401005147992344 433 43811474
SGTC_2778 tioconazole 65.09 nM 0.249795084782658 0.43051576832365 no 1406 0.401372910527286 440 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.249627601105533 0.430566229062607 no 1407 0.401437675796116 436 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3110 9122132 49.47 µM 0.249099949560983 0.430725211287897 no 1408 0.401641734235835 414 918317
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.248809919946029 0.430812602442312 no 1409 0.401753908682833 446 97141
SGTC_1212 0520-0165 585 µM 0.248390694344276 0.430938928664897 no 1410 0.401916066429709 455 5403258
SGTC_3188 9110789 49.47 µM 0.248387141162217 0.430939999383701 no 1411 0.401917440883619 430 849217
SGTC_2388 9080168 200 µM 0.247959720914757 0.431068802253505 no 1412 0.402082785875179 442 15943073
SGTC_463 ikarugamyin 104 µM 0.247870640423897 0.431095647536885 no 1413 0.402117248343282 452 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2512 diallyl trisulfide 49.23 µM 0.247587977028843 0.431180833042372 no 1414 0.402226607046172 465 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2390 9097792 176.6 µM 0.247536730383002 0.43119627744883 no 1415 0.402246434510742 409 4497149
SGTC_1679 SEC14.276 6.7 µM 0.24621374548855 0.431595027042769 no 1416 0.402758387832868 454 1005053 YMR079W SEC14
SGTC_518 1021-0119 62.6 µM 0.244774171600379 0.432028995920803 no 1417 0.40331564686559 421 1097762
SGTC_962 1254-0300 21.5 µM 0.244365379253569 0.432152244000082 no 1418 0.403473926228326 416 7340576
SGTC_82 0054-0107 293.755 µM 0.243904890050065 0.432291086233805 no 1419 0.403652240914057 424 3104697
SGTC_429 1112-0049 25.5 µM 0.243820061457633 0.432316663839972 no 1420 0.403685091174523 389 2836170
SGTC_688 0527-0193 473 µM 0.243227895052395 0.432495222371306 no 1421 0.403914429237929 439 4007154
SGTC_2951 9072950 58.06 µM 0.242867255677686 0.432603974299893 no 1422 0.404054116194819 459 16488155
SGTC_179 1273-0063 6.77 µM 0.241977900481523 0.432872183937058 no 1423 0.404398643650358 448 3108139
SGTC_3013 9080133 71.4286 µM 0.241060338661914 0.43314893247469 no 1424 0.404754175788277 416 17050193
SGTC_1691 st019933 84.6 µM 0.240742232620283 0.433244885040664 no 1425 0.404877452256176 465 6176082
SGTC_1474 0330-0125 5.35 µM 0.239411572977694 0.433646303878159 no 1426 0.405393228485734 444 X1474
SGTC_3102 9121669 49.47 µM 0.239350948051915 0.43366459417575 no 1427 0.40541673119959 433 41905072
SGTC_791 1348-1292 225 µM 0.238623086256118 0.433884198247531 no 1428 0.405698930973439 440 5437054
SGTC_392 N-ethylmaleimide 8.33 µM 0.238587625581507 0.433894897652917 no 1429 0.4057126807082 417 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2953 9074162 66.49 µM 0.238357599465167 0.433964303674914 no 1430 0.405801875238932 470 16451992
SGTC_1347 1493-0251 600 nM 0.236902295907406 0.434403461048479 no 1431 0.406366294404105 434 3986378
SGTC_717 1532-0246 73.2 µM 0.236109163559813 0.434642833494559 no 1432 0.406673981721635 408 9561992
SGTC_364 0083-0097 67.7 µM 0.23581686449699 0.434731057279572 no 1433 0.406787390597351 412 5207356
SGTC_542 3381-0244 89.3 µM 0.23369680747264 0.435371044994828 no 1434 0.407610183201748 472 1112843
SGTC_1386 3228-0095 33.8 µM 0.233623959511448 0.435393038837066 no 1435 0.407638462709228 453 870181
SGTC_491 tetrandrine 80.3 µM 0.233514714453265 0.435426021858443 no 1436 0.407680872436286 450 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_538 2922-0838 53.3 µM 0.233258514274927 0.435503374999737 no 1437 0.407780335454007 415 777039
SGTC_3097 9117246 49.47 µM 0.232007925458877 0.435880993921678 no 1438 0.408265929058767 423 16423892
SGTC_2374 9071832 200 µM 0.23173681929831 0.435962862935837 no 1439 0.408371216015727 448 17381698
SGTC_1668 st014914 51.6 µM 0.231266655793351 0.436104850066616 no 1440 0.408553824685739 460 2839556
SGTC_2273 7815444 169.05 µM 0.231138173118695 0.436143652653549 no 1441 0.408603730037942 475 2824616
SGTC_2488 5268135 45.7 µM 0.229360472940397 0.436680592361041 no 1442 0.409294377659902 439 1270356 YLR208W SEC13
SGTC_2081 5214970 32.255 µM 0.227824486638547 0.437144618382146 no 1443 0.409891344822778 433 2063512
SGTC_3010 9080089 71.4286 µM 0.227101144817111 0.437363172085566 no 1444 0.410172546935279 432 17027233
SGTC_2982 9019404 25.97 µM 0.226411158105395 0.437571665541735 no 1445 0.410440825164545 380 22333232
SGTC_1629 st005085 44.9 µM 0.225362972034214 0.437888429338709 no 1446 0.410848457381249 472 24207091
SGTC_2992 9074591 71.4286 µM 0.224975976642994 0.438005390143856 no 1447 0.41099898154063 437 17741321
SGTC_2213 7173844 200 µM 0.222375888977523 0.4387913491215 no 1448 0.41201063987509 440 892728
SGTC_191 3914-0123 66.505 µM 0.220851527590241 0.439252248166783 no 1449 0.412604020404723 457 3144412
SGTC_857 0438-0306 1.35 µM 0.219739197333064 0.439588619351409 no 1450 0.413037137803021 407 4686136
SGTC_2029 5175081 200 µM 0.219084169184509 0.439786721766257 no 1451 0.413292241193542 421 1380876
SGTC_186 3455-3465 67.277 µM 0.217119647902949 0.440380948915376 no 1452 0.414057551181212 462 755278
SGTC_2517 totarol 10 µM 0.216672329898916 0.440516272200101 no 1453 0.414231856642363 420 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1739 st037196 92.5 µM 0.215794085798944 0.440781980062098 no 1454 0.414574129281269 444 612214
SGTC_3210 9128157 49.47 µM 0.213894863018659 0.441356670357172 no 1455 0.415314523126427 420 17590849
SGTC_2117 5521686 200 µM 0.213687162969418 0.441419526317219 no 1456 0.41539551129965 430 803312
SGTC_3043 9092303 49.47 µM 0.21126525524751 0.44215257318518 no 1457 0.416340146656387 418 25236084
SGTC_2886 9058944 51.95 µM 0.206327693538479 0.443647652503032 no 1458 0.418267473792704 452 4949929
SGTC_2591 skatole 100 µM 0.205767932596651 0.44381719752777 no 1459 0.41848609561683 459 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1617 st002906 78 µM 0.201238726333981 0.445189416572373 no 1460 0.42025595580033 467 5150859
SGTC_418 lividomycin a 100 µM 0.200104526702545 0.445533149898718 no 1461 0.42069941658486 438 72394 An antibiotic.
SGTC_1026 k007-1105 30.6 µM 0.196799979859663 0.446534866506935 no 1462 0.421992033438872 419 7066794
SGTC_2502 avocadyne acetate 18.59 µM 0.196250883323705 0.446701348925527 no 1463 0.422206901591789 418 3952079
SGTC_3035 9091303 49.47 µM 0.195411084797323 0.446955988415456 no 1464 0.422535569737119 472 25237002
SGTC_2956 9076196 2.52 µM 0.195046813430038 0.447066447756021 no 1465 0.422678149758349 497 16423868
SGTC_83 0170-0301 39.027 µM 0.194572949836776 0.447210145292623 no 1466 0.422863640601017 443 3089716
SGTC_3192 9110362 49.47 µM 0.194306694132663 0.447290889479138 no 1467 0.422967872183939 454 16649480
SGTC_1251 0490-5699 265 µM 0.193010874795855 0.447683888256752 no 1468 0.423475225686145 462 3883818
SGTC_2321 7390090 138.78 µM 0.192434370447282 0.447858748223839 no 1469 0.423700985876564 454 649046
SGTC_2493 resveratrol 26.09 µM 0.190069673778201 0.448576091807844 no 1470 0.424627266843582 469 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1776 st049249 45.9 µM 0.188737891933832 0.448980169240654 no 1471 0.425149125906098 443 1822314
SGTC_714 4296-0578 26.1 µM 0.188388221875912 0.449086271816816 no 1472 0.425286165990085 459 1589775
SGTC_629 3448-6466 76.7 µM 0.188151554217726 0.449158087433538 no 1473 0.425378924139324 476 573744
SGTC_2062 5245942 200 µM 0.187055231278074 0.449490782836136 no 1474 0.425808664399066 452 1376160
SGTC_2340 7987427 183.45 µM 0.185747678294102 0.449887625531025 no 1475 0.426321318507448 451 2239331
SGTC_2491 paeonol 100 µM 0.185456429047258 0.449976026597687 no 1476 0.426435525990526 455 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1612 st002233 45.4 µM 0.18318999047099 0.450664029040948 no 1477 0.427324473959776 473 1035021
SGTC_2657 nystatin 74.44 µM 0.181256605018204 0.451251046804203 no 1478 0.428083082977826 444 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2427 5545055 42.75 µM 0.179235977169565 0.451864667184469 no 1479 0.42887620770758 450 5372858
SGTC_2648 atorvastatin 78.68 µM 0.175886225818757 0.452882165914194 no 1480 0.430191663428022 483 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_836 0330-0104 1.35 µM 0.17451675625398 0.45329823659976 no 1481 0.430729681620537 449 46494820
SGTC_1155 4088-0394 48.2 µM 0.174373713000592 0.453341698803555 no 1482 0.430785885902854 453 2326248
SGTC_2351 9026858 72.31 µM 0.174261712025315 0.453375729524361 no 1483 0.430829894091092 462 1409300
SGTC_1150 3909-7983 10.9 µM 0.174173354613925 0.453402576553602 no 1484 0.430864612694826 466 23965914
SGTC_369 0957-0393 4.5 µM 0.173805528820902 0.453514341166881 no 1485 0.43100914958004 450 6997992
SGTC_2160 5660466 132.927 µM 0.173480108755546 0.453613223783715 no 1486 0.431137030869156 480 2859134
SGTC_2075 5212009 200 µM 0.171816840367208 0.454118671730529 no 1487 0.431790762855928 495 780898
SGTC_396 dithiazanine 1.25 µM 0.171792101289287 0.454126190211907 no 1488 0.431800487732272 472 10578 An antihelmenthic.
SGTC_1207 2099-0101 141 µM 0.171191965609637 0.454308583160357 no 1489 0.432036412377903 465 5837381
SGTC_1399 3562-5772 25 µM 0.170895717479807 0.454398622304645 no 1490 0.432152882041991 463 23847490
SGTC_1821 st053465 65.6 µM 0.170594540280528 0.454490161950595 no 1491 0.432271295609586 441 675086
SGTC_1762 st045503 25.4615 µM 0.169665510195386 0.454772546092344 no 1492 0.432636599813503 457 4645554
SGTC_20 0481-0013 4.944 µM 0.169261233424279 0.454895435533339 no 1493 0.432795583606055 478 182045
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.169212077743986 0.454910377854037 no 1494 0.432814915057041 445 6312947
SGTC_2686 alizarin 95.37 µM 0.168868762911351 0.45501474031389 no 1495 0.432949934938242 431 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_166 k072-0058 166.424 µM 0.168378144060327 0.455163886330293 no 1496 0.433142900565904 496 5846229
SGTC_2649 anisomycin 9.56 µM 0.16769828056847 0.455370572344481 no 1497 0.433410324470865 468 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3324 9138759 60.749 µM 0.164851058168282 0.456236290011399 no 1498 0.43453060757862 462 45595710
SGTC_1244 0416-0015 52.5 µM 0.16368675881069 0.456590363378544 no 1499 0.434988870942877 468 96201
SGTC_3130 9127414 49.47 µM 0.162576580594455 0.456928010152314 no 1500 0.435425913809203 487 1494646
SGTC_1311 1190-0148 100 µM 0.162004693859797 0.457101954477489 no 1501 0.435651078767935 470 1961333
SGTC_1102 cgs 12066b 26.1 µM 0.161906018193414 0.457131968372134 no 1502 0.435689931759335 458 6438352 A 5-HT1B full agonist.
SGTC_1184 1269-1718 139 µM 0.160455791675913 0.457573107731264 no 1503 0.436261021739983 459 5403821
SGTC_1401 3807-4679 7.6 µM 0.159042715468421 0.458002996756649 no 1504 0.436817610017534 472 3291456
SGTC_2902 5787006 60.46 µM 0.158099174919534 0.458290070041078 no 1505 0.437189325377231 454 591003
SGTC_1882 5615643 20 µM 0.15732844712322 0.458524581001012 no 1506 0.437493000932177 475 2253075
SGTC_2787 5284540 71.43 µM 0.155843496873181 0.458976450553899 no 1507 0.438078191963313 476 736958
SGTC_2134 5324836 1.464 µM 0.151546152072195 0.460284426856878 no 1508 0.439772453560104 506 699272
SGTC_1068 loratadine 26.9 µM 0.150812722247397 0.460507703112179 no 1509 0.440061725077923 477 3957 A H1 histamine antagonist.
SGTC_1695 st026914 34.495 µM 0.15001517401299 0.460750512909187 no 1510 0.440376321802078 460 3289191
SGTC_913 3487-1245 167 µM 0.149709668242531 0.460843526581122 no 1511 0.440496839999487 474 4016153
SGTC_2193 5925765 200 µM 0.149620144176437 0.460870783304181 no 1512 0.440532157166325 458 877370
SGTC_220 paclitaxel 373.376 µM 0.149539564958614 0.460895316813368 no 1513 0.44056394600277 476 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2545 solidagenone 89.61 µM 0.149507066505536 0.460905211479922 no 1514 0.440576766886033 466 6708572 An anti ulcer agent
SGTC_586 0957-0265 8.15 µM 0.149376475735697 0.460944972143256 no 1515 0.440628286551264 499 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2247 cerulenin 830 nM 0.149220317912187 0.460992517659597 no 1516 0.440689894053037 494 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1630 st005209 31.3 µM 0.149215350531358 0.460994030091767 no 1517 0.440691853811419 489 3367314
SGTC_1126 isoteolin 1.0172 µM 0.14769670861085 0.461456441544628 no 1518 0.441291064648266 443 133323
SGTC_1857 st056007 79.3 µM 0.147250649367315 0.461592272104137 no 1519 0.441467091929832 463 619834
SGTC_2829 7992743 58.44 µM 0.147162922168452 0.461618986649499 no 1520 0.441501712864045 496 16462845
SGTC_581 0958-0271 211 µM 0.146735324689574 0.461749200422275 no 1521 0.441670467654976 458 4591145
SGTC_1525 8-methoxypsoralen 92.5 µM 0.145432736102505 0.462145895359507 no 1522 0.442184609869973 499 4114 Related to psoralen; DNA damaging agent.
SGTC_1295 1013-0063 9.78 µM 0.142959659666413 0.462899158105519 no 1523 0.443161020397852 480 6826038
SGTC_1258 0671-0043 57.1 µM 0.141351314808679 0.463389107891322 no 1524 0.443796206582715 470 4298767
SGTC_1610 st001799 48.1 µM 0.14119450324117 0.463436880352374 no 1525 0.44385814417648 472 621897
SGTC_120 rhodamine 6G 52.259 µM 0.138817272074064 0.464161165240629 no 1526 0.444797272496498 505 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_977 1348-1378 135 µM 0.138744232784281 0.464183420440262 no 1527 0.444826131699314 503 X977
SGTC_553 k007-0256 45.7 µM 0.138529984266303 0.464248702985494 no 1528 0.444910787021648 466 6287000
SGTC_2440 5628896 157.78 µM 0.136889732021456 0.464748527430277 no 1529 0.445558977545306 495 5522048
SGTC_3078 9116413 49.47 µM 0.13635230297806 0.464912307167938 no 1530 0.445771389069043 487 17177322
SGTC_621 3584-0052 32.1 µM 0.135807691773378 0.465078281709762 no 1531 0.445986655123566 501 2273927
SGTC_1636 st007707 68.9 µM 0.135229503024501 0.465254495920407 no 1532 0.446215210648541 501 403051
SGTC_2119 5528445 120.635 µM 0.135010049879732 0.465321380298967 no 1533 0.446301964215364 488 791935
SGTC_2332 7982454 138.89 µM 0.135000820011614 0.465324193376484 no 1534 0.44630561299583 505 2981748
SGTC_1326 1431-2094 10.8 µM 0.134508401861767 0.465474274998906 no 1535 0.446500283870015 490 616278
SGTC_1004 4084-0029 199 µM 0.133645962347951 0.465737145370192 no 1536 0.446841268740601 488 716894 YLR208W SEC13
SGTC_1546 5-methoxyflavanone 78.7 µM 0.132683842449527 0.466030415821852 no 1537 0.447221710864648 477 147795
SGTC_2163 5671233 125 µM 0.129166119416751 0.46710283325505 no 1538 0.448613102189052 489 701023
SGTC_2968 9090663 33.37 µM 0.128660032613598 0.467257139345129 no 1539 0.448813330920042 494 25236811
SGTC_2927 9011802 47.9 µM 0.127875766018754 0.467496272289632 no 1540 0.449123644744255 463 43912568
SGTC_1466 k213-0079 57.5 µM 0.127001596124782 0.467762831724711 no 1541 0.449469567627775 497 3657981
SGTC_3154 9100113 49.47 µM 0.126254818298459 0.467990557124071 no 1542 0.449765109879995 465 25237525
SGTC_443 clozapine 122 µM 0.126104089776936 0.468036522151618 no 1543 0.449824765072038 506 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_122 0236-0016 402.397 µM 0.126071718349925 0.468046393952265 no 1544 0.449837577152838 496 6808838
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.125544654523991 0.468207127007558 no 1545 0.450046187732461 499 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2234 tolnaftate 200 µM 0.125508368120957 0.468218193077367 no 1546 0.450060550311025 494 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1252 0493-0875 34.8 µM 0.125296854803591 0.468282697648383 no 1547 0.450144271032919 473 3960963
SGTC_2738 aclarubicin 5.55 µM 0.125060930011483 0.468354647894709 no 1548 0.450237656866937 491 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2671 danthron 100 µM 0.123741169561516 0.468757155705841 no 1549 0.450760106773462 475 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_428 3448-4153 16.5 µM 0.121504569214808 0.469439359105216 no 1550 0.451645697904811 441 3834874
SGTC_408 cantharidin 100 µM 0.119870740025057 0.469937763269526 no 1551 0.452292771694593 463 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3162 9099653 49.47 µM 0.119413210064735 0.470077342539377 no 1552 0.452473998030866 507 25237511
SGTC_3196 9111891 49.47 µM 0.118586104857666 0.470329677937835 no 1553 0.452801637191146 505 18891510
SGTC_2335 9018011 154.17 µM 0.115897561911148 0.471149987369283 no 1554 0.453866863994416 499 6458208
SGTC_2727 riluzole 51.77 µM 0.114586821334098 0.47154995597852 no 1555 0.454386312975116 499 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3167 9103034 49.47 µM 0.114473759150056 0.471584457919608 no 1556 0.454431123401368 471 5127859
SGTC_1957 st077035 62.4 µM 0.114427248956124 0.471598650985005 no 1557 0.454449557156845 508 705593
SGTC_2001 4023502 57.655 µM 0.114258076833606 0.471650275907144 no 1558 0.454516607318213 484 108941 YCR052W RSC6
SGTC_2568 diosmetin 100 µM 0.113803684588601 0.471788941559724 no 1559 0.454696708846558 513 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_525 k781-2675 26.7 µM 0.113726182160373 0.471812593108003 no 1560 0.454727428404073 503 3651118 YDL195W SEC31
SGTC_3245 9134821 49.47 µM 0.112702764051628 0.472124920649901 no 1561 0.455133104909021 482 17014901
SGTC_2748 diazoxide 86.69 µM 0.111997171840221 0.472340263829706 no 1562 0.455412824504044 507 3019 A potassium channel activatior.
SGTC_2203 7227154 166.4 µM 0.111590749552914 0.472464305533327 no 1563 0.4555739534983 473 896304
SGTC_536 3852-0578 10.6 µM 0.111157238628801 0.472596617740171 no 1564 0.455745830028521 460 2869208
SGTC_2892 9047358 58.44 µM 0.111052555841817 0.472628568508942 no 1565 0.455787335448408 484 6466771
SGTC_2652 actinonin 100 µM 0.110972336230386 0.472653052865999 no 1566 0.455819141850765 501 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_766 1391-0721 126 µM 0.110842929347274 0.472692550212637 no 1567 0.455870451190041 498 1020919 YIL115C NUP159
SGTC_1603 st002045 67.8 µM 0.110381429528052 0.472833410578518 no 1568 0.45605344010795 502 5887985
SGTC_345 1362-0200 395 µM 0.107451715403207 0.473727705266102 no 1569 0.45721531449679 470 1419823
SGTC_2556 citropten 84.59 µM 0.107003872653201 0.473864420961789 no 1570 0.457392953731971 460 2775 A potential DNA crosslinker.
SGTC_1308 1187-1617 41.4 µM 0.105355284035926 0.474367722092043 no 1571 0.458046948349128 513 2882570
SGTC_1430 4049-0248 69.1 µM 0.104243556093622 0.474707147029608 no 1572 0.4584880347362 498 22774488
SGTC_440 fluspirilene 35.1 µM 0.104242847402831 0.474707363407965 no 1573 0.458488315930941 498 3396 An atypical antipsychotic.
SGTC_19 0279-0214 38.434 µM 0.103906502621244 0.474810057457655 no 1574 0.458621773349207 511 3566274 YBR002C RER2
SGTC_1439 4092-1168 46 µM 0.1033235847331 0.474988040092482 no 1575 0.458853078941572 510 2886240
SGTC_2078 5212016 200 µM 0.102319190371768 0.475294724057336 no 1576 0.45925166176701 517 1899708
SGTC_1001 4048-4355 44.4 µM 0.102252410728912 0.475315115220109 no 1577 0.459278163988533 492 21824233
SGTC_547 1120-0019 610 nM 0.101413552813286 0.475571265959626 no 1578 0.459611089175889 508 3676939
SGTC_3082 9117008 49.47 µM 0.0991949568731237 0.476248777094948 no 1579 0.460491739471975 500 41448529
SGTC_1379 2144-0755 36.5 µM 0.0989488987431839 0.476323922183144 no 1580 0.460589421896388 509 5392327
SGTC_2226 7298446 200 µM 0.0980547398235495 0.476597001517949 no 1581 0.460944413327487 502 3283010
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0959891287720461 0.477227888336904 no 1582 0.461764603337679 463 16623 A steroid.
SGTC_2764 methyldopa 94.69 µM 0.0952056756053758 0.477467188611565 no 1583 0.462075730993021 504 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1521 st012942 49.4 µM 0.0927510807831733 0.478216979592316 no 1584 0.463050657640605 493 24207259
SGTC_1192 1488-0095 21.4 µM 0.0919755486081367 0.478453893105998 no 1585 0.463358733306768 498 915875
SGTC_968 1309-0633 340 µM 0.0907430780351466 0.478830410115868 no 1586 0.463848370243845 513 3761976
SGTC_3141 9094609 49.47 µM 0.0904100064709059 0.478932165992307 no 1587 0.46398070262302 502 25236309 YDL196W YDL196W
SGTC_2980 9014342 25.29 µM 0.0901652170700809 0.479006951877439 no 1588 0.464077962232555 505 2996599
SGTC_3207 9114163 49.47 µM 0.0897647033523653 0.47912931486647 no 1589 0.464237098781257 495 849233
SGTC_3132 9126706 49.47 µM 0.0865947278329073 0.480097858718365 no 1590 0.465496828369623 520 850858
SGTC_2394 5221648 200 µM 0.0851519794617531 0.480538710548 no 1591 0.466070283347228 504 788586
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0844389206056013 0.480756604421481 no 1592 0.466353731798184 466 6708561
SGTC_2610 ononetin 44.17 µM 0.0840261528096665 0.480882739101144 no 1593 0.466517819179204 500 259632
SGTC_991 3996-0057 64.7 µM 0.0834143201577582 0.481069708065823 no 1594 0.466761051177368 486 715343
SGTC_3179 9107801 49.47 µM 0.0826754674492049 0.481295498434116 no 1595 0.467054796107522 486 4818259
SGTC_3047 9092122 49.47 µM 0.0824640349160534 0.481360112459605 no 1596 0.467138858436762 505 17173831
SGTC_825 1988-2224 89.6 µM 0.0813951880574344 0.481686760749556 no 1597 0.467563837894485 499 1180859
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0811657035838385 0.481756894681205 no 1598 0.467655087035895 503 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1606 st000094 49.2 µM 0.0801414485991577 0.482069929374432 no 1599 0.468062378764581 507 1242210
SGTC_789 1309-1135 70.6 µM 0.0800118888731254 0.482109526447916 no 1600 0.468113900167364 501 3092424
SGTC_2967 9089538 49.85 µM 0.0797047247028936 0.482203405108111 no 1601 0.468236050821078 522 728216
SGTC_2416 tofa 880 nM 0.0795206909605976 0.482259651858677 no 1602 0.468309237359053 455 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1910 st062352 60.4 µM 0.0788466759878874 0.482465655958 no 1603 0.468577288756995 508 2245730
SGTC_903 1134-0042 114 µM 0.0775847749387311 0.482851352499908 no 1604 0.469079176855283 506 701009
SGTC_1571 st070080 73.4 µM 0.0771857776611638 0.48297330826343 no 1605 0.469237877836989 511 4315245
SGTC_1622 st003707 19.4 µM 0.077172954023726 0.482977227906871 no 1606 0.46924297851402 510 10140899
SGTC_262 fenpropimorph 62.5 µM 0.0752334393738829 0.483570074205135 no 1607 0.470014489481615 512 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1409 3909-8004 61.9 µM 0.0742468522005712 0.4838716557105 no 1608 0.47040698301812 511 2119279
SGTC_1771 st048882 4.1505 µM 0.0741487201693881 0.48390165337016 no 1609 0.470446024418823 515 4580403
SGTC_3342 9147791 14.508 µM 0.0741227714875439 0.483909585553084 no 1610 0.470456348036252 516 1838168
SGTC_3281 9140613 49.47 µM 0.0727344492820167 0.484333987247423 no 1611 0.471008717288118 510 16013766
SGTC_2120 5538279 151.968 µM 0.0726463161800761 0.484360929607364 no 1612 0.471043784540501 509 2058197
SGTC_1744 st037937 38.9 µM 0.0722726340146219 0.484475165336719 no 1613 0.471192471311384 499 1016152
SGTC_2026 5148700 152 µM 0.0703953461897966 0.485049076798051 no 1614 0.471939497631895 517 79838
SGTC_814 3342-0569 96 µM 0.0681857797265657 0.485724609778885 no 1615 0.472818873379545 522 4346283
SGTC_484 loperamide 105 µM 0.0677478269074235 0.485858510461952 no 1616 0.47299318818676 510 3955 An opioid-receptor agonist.
SGTC_1054 3429-0080 167 µM 0.0674917690355884 0.485936798913025 no 1617 0.473095107222041 511 1162877
SGTC_2714 st079313 56.9 µM 0.0672917453109232 0.485997955572903 no 1618 0.473174724141279 512 2939799
SGTC_1323 1348-1351 11.2 µM 0.0670676084251528 0.486066485151383 no 1619 0.473263940273044 524 6989654
SGTC_2762 leflunomide 42.06 µM 0.0657327826579941 0.486474614948968 no 1620 0.473795286029118 519 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2080 5212524 12.4 µM 0.0650847327042368 0.48667276466803 no 1621 0.474053268097238 520 260183
SGTC_574 1315-0397 40 µM 0.0644899831184609 0.486854620001639 no 1622 0.474290041411607 524 6794277
SGTC_1139 k015-0024 46.9 µM 0.0640133289955254 0.487000367508295 no 1623 0.474479806786184 523 2766652
SGTC_2399 5884133 200 µM 0.0634997577166731 0.487157405191935 no 1624 0.474684276085172 504 722445
SGTC_988 1497-1057 103 µM 0.0632152191105131 0.487244411079 no 1625 0.474797562960396 524 3533044
SGTC_2171 5739187 198.077 µM 0.0629922986319935 0.487312575870363 no 1626 0.474886318472251 519 2262761
SGTC_1359 1582-0056 520 nM 0.0624669503470338 0.487473218726015 no 1627 0.475095490161628 505 3661189
SGTC_2614 arthonioic acid 13.39 µM 0.0622183927049288 0.487549224270361 no 1628 0.475194457802686 516 6710684
SGTC_756 0508-1999 28.3 µM 0.0621319305406934 0.487575663329679 no 1629 0.475228884608568 514 6753853
SGTC_472 calcifediol 10 µM 0.0619282966468157 0.487637932268731 no 1630 0.47530996663719 520 5283731 A vitamin D metabolite.
SGTC_802 4112-3352 742 µM 0.0615494836877338 0.487753769783018 no 1631 0.475460803396394 482 704594
SGTC_1788 fluconazole 20 µM 0.0595939529060897 0.488351769304096 no 1632 0.4762395173462 524 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2938 9059746 27.26 µM 0.0590688451862095 0.488512351279713 no 1633 0.476448636618523 512 6471769
SGTC_2910 7948405 25.97 µM 0.0588395437192764 0.488582474015931 no 1634 0.47653995583607 523 2971328
SGTC_283 0987-0079 11.7 µM 0.0584757015942653 0.488693741386305 no 1635 0.47668485834354 522 411556
SGTC_2369 9071472 200 µM 0.0584413456731885 0.48870424789263 no 1636 0.47669854097355 520 17296037
SGTC_1277 0873-0036 22 µM 0.0560763771856829 0.489427505756672 no 1637 0.477640481297525 507 5965735
SGTC_2565 isoliquiritigenin 100 µM 0.0560749472728898 0.489427943065294 no 1638 0.477641050854011 524 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1854 st056233 32.9 µM 0.0531829075438646 0.490312437607532 no 1639 0.478793087072279 521 5393174
SGTC_413 propylparaben 100 µM 0.0515591577671319 0.490809062533318 no 1640 0.479439981704417 509 7175 A pharmaceutical preservative.
SGTC_383 2324-0395 7.37 µM 0.04953776486089 0.491427326690703 no 1641 0.480245371061446 537 3146421
SGTC_3178 9107506 49.47 µM 0.0495366772021398 0.491427659368182 no 1642 0.480245804442437 517 8897194
SGTC_2695 st077686 51.995 µM 0.0488476541258387 0.491638409066094 no 1643 0.480520352488104 521 2876092
SGTC_2058 5236698 133 µM 0.0464538748710372 0.492370605870734 no 1644 0.481474248444466 510 766665
SGTC_3297 9117502 71.43 µM 0.0463722885622053 0.492395561535467 no 1645 0.481506761634149 529 7453720
SGTC_1671 st016596 74.5 µM 0.0461776316827917 0.492455103408166 no 1646 0.481584335391782 529 2829167
SGTC_1178 0988-0033 191 µM 0.0433203223597811 0.493329119155765 no 1647 0.482723095763669 523 5392207
SGTC_1217 1183-1422 255 µM 0.0429241330130323 0.493450311222994 no 1648 0.482881005557101 525 2849664
SGTC_480 am 92016 50 µM 0.0428621055788751 0.493469285117244 no 1649 0.482905728170088 529 2129 K+ channel blocker.
SGTC_2966 9084041 48.03 µM 0.0428304323585641 0.493478973808941 no 1650 0.482918352363741 486 17741380
SGTC_1029 k015-0030 64.7 µM 0.0413220966568583 0.493940371079256 no 1651 0.483519558764108 535 2208316
SGTC_1286 0929-0070 131 µM 0.0401877492058067 0.494287371368046 no 1652 0.483971722229243 526 1420408
SGTC_707 0865-0008 204 µM 0.0397299783753003 0.494427406077553 no 1653 0.484154200625893 534 723043
SGTC_1896 st058441 89 µM 0.0395420190264951 0.494484904114864 no 1654 0.484229126679017 530 688759
SGTC_2767 sibutramine 71.45 µM 0.0378441911973474 0.495004286189285 no 1655 0.484905955055028 527 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1703 st026983 48.3 µM 0.0368464381200001 0.495309512583526 no 1656 0.485303723451432 515 1104023
SGTC_301 4119-0100 24.5 µM 0.0368265805896471 0.495315587303738 no 1657 0.485311640086897 528 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_722 3534-0461 190 µM 0.0354196720270359 0.495745984688222 no 1658 0.485872549271882 528 658262
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0345474799271896 0.49601280568248 no 1659 0.486220290709226 533 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_281 1672-3440 14.9 µM 0.0345259744803519 0.496019384651481 no 1660 0.486228865026043 533 6833000
SGTC_2317 5986382 200 µM 0.0326832602495071 0.4965831135675 no 1661 0.486963586572777 540 877883
SGTC_2204 7233102 200 µM 0.0320121086782984 0.496788436115173 no 1662 0.487231197259181 531 2172480
SGTC_1837 st055472 66.5 µM 0.0317825216037228 0.496858672911136 no 1663 0.487322742667293 516 676091
SGTC_1913 st060213 96.1 µM 0.0315254899007444 0.496937305864719 no 1664 0.487425232121878 520 688959
SGTC_190 3970-0790 3.722 µM 0.0314011663891777 0.496975339834162 no 1665 0.487474805483632 532 2832352
SGTC_2529 gangaleoidin 93.61 µM 0.0301237633472462 0.497366133964224 no 1666 0.487984174459149 534 4565183
SGTC_2641 levomentholum 100 µM 0.0300577197086471 0.497386338674357 no 1667 0.488010510133379 536 16666
SGTC_2311 7694451 200 µM 0.0270979859560694 0.498291815220422 no 1668 0.489190790573185 537 2163142
SGTC_1562 morin hydrate 59.1 µM 0.0264557143358292 0.498488307828196 no 1669 0.489446928031897 531 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2393 9031399 185.94 µM 0.0258031198035335 0.498687958939201 no 1670 0.489707186717661 538 1526623 YDL150W RPC53
SGTC_149 3970-0822 46.1 µM 0.025376810737363 0.498818381724433 no 1671 0.489877203750759 527 3114250 YBL034C STU1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.025212234638887 0.498868731317201 no 1672 0.489942839114176 540 229346 A bile salt which induces apoptosis.
SGTC_1254 0550-0035 264 µM 0.0250978438472696 0.498903727477535 no 1673 0.489988460001231 539 15121435
SGTC_701 4424-0219 185 µM 0.023617945597965 0.499356480987027 no 1674 0.490578678813267 531 2911779
SGTC_460 trequinsin 123 µM 0.0228259260998485 0.499598788298589 no 1675 0.49089456368646 540 5537 A vasodilator.
SGTC_1421 4029-0249 71.4 µM 0.0220689300169556 0.499830380824637 no 1676 0.49119648534603 538 2894095
SGTC_3248 9135562 49.47 µM 0.0209600771301285 0.499830380824637 no 1677 0.491638751254167 528 17650701
SGTC_2215 7188065 200 µM 0.0187417086925953 0.499151702003948 no 1678 0.492523577682391 536 940217
SGTC_1960 st011366 51.8 µM 0.0185988136974919 0.499107985340387 no 1679 0.492580574602727 542 3972846
SGTC_1395 3486-0190 4.35 µM 0.0182425538409746 0.498998992821448 no 1680 0.492722677610195 536 6748079
SGTC_598 3937-0236 20.2 µM 0.0174986997722995 0.498771421743804 no 1681 0.493019385059874 540 1379313
SGTC_3075 9116269 49.47 µM 0.0174865742172273 0.498767712113868 no 1682 0.493024221716419 540 17015205 YNL244C SUI1
SGTC_1714 st033236 13.627 µM 0.0168820312957659 0.498582761504398 no 1683 0.493265363837142 542 2916566
SGTC_1583 clindamycin 39.6 µM 0.0156997826216223 0.498221071621416 no 1684 0.493736950209579 530 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1367 1812-0510 76.9 µM 0.0150498446058886 0.498022234188936 no 1685 0.49399620731509 538 1142582 YDR527W RBA50
SGTC_1531 st059297 52.4 µM 0.014610846763915 0.497887930573929 no 1686 0.494171322855412 541 7566702
SGTC_1216 1165-0504 9.65 µM 0.0143613540854921 0.497811602813234 no 1687 0.4942708455904 537 6304004
SGTC_2907 7721985 69.9 µM 0.0119222675640652 0.497065413172356 no 1688 0.495243816065068 543 3267881
SGTC_1325 1431-0015 227 µM 0.0101847757239909 0.496533868473047 no 1689 0.495936932590847 535 1103340
SGTC_268 camptothecin 39.6153 µM 0.00961520311212321 0.496359622442776 no 1690 0.496164148049465 546 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1344 1488-0097 29.1 µM 0.00899989617664055 0.496171385958764 no 1691 0.496409609365136 541 747966
SGTC_1481 3346-2004 36 µM 0.00830244439324918 0.495958020517376 no 1692 0.496687841952392 543 2770522
SGTC_632 0781-2353 4.65 µM 0.00774784010654888 0.495788356007612 no 1693 0.496909089923792 542 6811515 YHR007C ERG11
SGTC_1411 3909-8223 150 µM 0.00762877184107457 0.495751930749342 no 1694 0.496956589885233 545 X1411
SGTC_864 0469-0573 172 µM 0.00676429515485165 0.495487471888513 no 1695 0.497301457244578 531 689425
SGTC_963 1269-2853 151 µM 0.00592974694680747 0.49523217056384 no 1696 0.497634387094086 543 3668223
SGTC_2917 7979103 53.79 µM 0.0048913407699501 0.494914508642545 no 1697 0.498048645140116 547 2980565
SGTC_2867 9039098 71.43 µM 0.00436206403112628 0.494752597249574 no 1698 0.498259793746826 542 6463460
SGTC_1646 st011709 75.6 µM 0.0040394566290121 0.494653908630738 no 1699 0.498388494343386 545 5757843
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.00302943566364579 0.494344935923003 no 1700 0.498791431876618 542 65057 A dermal irritant. YDR527W RBA50
SGTC_219 mitoxanthrone 164.414 µM 0.00282861848019804 0.494283504894678 no 1701 0.498871545997933 537 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2255 7941087 197.44 µM 0.0027638795737509 0.49426370095291 no 1702 0.498897372983927 546 935561
SGTC_49 0717-0965 32.132 µM 0.000887771261337841 0.493689796767231 no 1703 0.499645830555049 546 5889349 YGL099W LSG1
SGTC_2013 4024628 200 µM -0.000330876098887352 0.49331701773937 no 1704 0.499867999536988 550 5230760
SGTC_1728 st035614 33.7865 µM -0.000777657701673073 0.493180350598208 no 1705 0.499689759494393 551 15945546
SGTC_1464 k208-0027 110 µM -0.000994494103343741 0.493114022256873 no 1706 0.499603254319964 546 X1464
SGTC_1158 4092-0494 91.8 µM -0.00120235833336439 0.493050438602358 no 1707 0.499520328540202 549 1148199
SGTC_2270 7924575 90.91 µM -0.00175462531503394 0.49288150634421 no 1708 0.49930000613475 553 1262135
SGTC_2515 chrysin 20.77 µM -0.00424988550335035 0.492118250675913 no 1709 0.498304546089598 553 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1713 st033146 12.748 µM -0.00438630821231064 0.492076522204558 no 1710 0.498250121810428 551 674619
SGTC_2284 7945075 39.21 µM -0.0044684633604153 0.492051392934896 no 1711 0.498217346969529 551 1245402
SGTC_3247 9135149 49.47 µM -0.00566278062825111 0.491686083827541 no 1712 0.497740889456607 551 8934436 YOR116C RPO31
SGTC_1085 doxorubicin 7.67 µM -0.00584375704672546 0.491630728673514 no 1713 0.49766869150651 551 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2003 4023581 200 µM -0.00602278336979441 0.491575970152638 no 1714 0.497597271594162 553 16641307
SGTC_2246 7293507 91.5585 µM -0.00657791786601585 0.491406172986218 no 1715 0.497375809370604 549 887656
SGTC_1324 1418-0026 34.4 µM -0.00724829669069512 0.491201128493843 no 1716 0.497108373309163 569 1372513
SGTC_3310 9130229 44.1445 µM -0.00748200669876667 0.491129645649161 no 1717 0.497015139034605 558 7761258
SGTC_2397 5161689 200 µM -0.00776715803896681 0.491042429278315 no 1718 0.496901383415669 555 2259942
SGTC_3290 9121031 71.43 µM -0.00865039325803695 0.490772285746307 no 1719 0.496549035426202 550 17014854
SGTC_2875 9039966 71.43 µM -0.00908453332597031 0.490639502581401 no 1720 0.496375845408112 563 6463691
SGTC_3312 9133330 71.43 µM -0.00968914089689376 0.490454583102612 no 1721 0.496134652515007 550 17617324
SGTC_3341 9147222 25.867 µM -0.00971683738215302 0.490446112169837 no 1722 0.496123603736142 557 1939759
SGTC_2934 9036370 36.88 µM -0.0125457740711171 0.489580909063584 no 1723 0.494995091575479 558 6462800
SGTC_1041 0206-0046 107 µM -0.0129173062817755 0.489467283061163 no 1724 0.494846883681121 570 50494
SGTC_276 colchicine 750 µM -0.0138316000071364 0.489187667516302 no 1725 0.494482165891159 553 2833 A microtubule depolymerizer.
SGTC_604 1000-0114 314 µM -0.0148306027031373 0.488882151776348 no 1726 0.494083662418574 556 1572745
SGTC_2472 5377652 49.4 µM -0.0148310969161243 0.488882000637369 no 1727 0.494083465277801 558 1610903
SGTC_1772 st048439 82.2 µM -0.0159975019049462 0.488525298076325 no 1728 0.493618192315917 557 2927068 YDL195W SEC31
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0164502727453951 0.488386837032537 no 1729 0.493437586656452 560 75037 A free radical scavenger.
SGTC_2414 st077232 92.9 µM -0.0167368932433387 0.488299186851294 no 1730 0.493323257362981 554 729801
SGTC_1023 4482-3888 16 µM -0.0171930649949317 0.488159688097881 no 1731 0.49314129735261 555 3303168
SGTC_698 k064-0052 127 µM -0.0197095162028113 0.487390175917788 no 1732 0.492137549711567 552 5088751
SGTC_2357 9067248 200 µM -0.0202289194454695 0.487231351995536 no 1733 0.491930379110614 568 9150235
SGTC_1144 3486-0183 12.5 µM -0.0206879779089093 0.487090982077712 no 1734 0.491747279603967 569 6744069
SGTC_266 formosanin C 406 nM -0.0262066821185751 0.48540361465047 no 1735 0.489546243077168 559 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1062 mesoridazine 14.2 µM -0.026617341015118 0.485278064009404 no 1736 0.489382471014861 551 4078 A neuroleptic.
SGTC_842 0271-0008 11.1 µM -0.0266907456051646 0.485255622195955 no 1737 0.489353197220777 558 1221709
SGTC_2212 7123476 200 µM -0.0269226138884353 0.485184733955671 no 1738 0.489260728389235 554 1085715
SGTC_3061 glucosamine 200 µM -0.0269502265256468 0.485176292076471 no 1739 0.489249716536442 554 91431 and experimental redox chemotherapeutic
SGTC_116 0155-0182 31.788 µM -0.0286143901976532 0.484667527699008 no 1740 0.488586067533101 565 771486
SGTC_1234 0326-0494 15.5 µM -0.0288844667865928 0.484584962823472 no 1741 0.48847836708116 558 1547813
SGTC_2897 9048598 12.99 µM -0.029392644823842 0.484429609958978 no 1742 0.48827571942612 561 6467404
SGTC_995 3931-2021 34.6 µM -0.0300144182825017 0.484239533557055 no 1743 0.488027777112476 567 730143
SGTC_947 3447-0010 211 µM -0.0302535366210804 0.484166435933784 no 1744 0.487932425999358 569 748350
SGTC_775 4577-0580 57.3 µM -0.0307639117761407 0.484010417852274 no 1745 0.487728910509692 584 2006902
SGTC_1690 st023502 41.2 µM -0.032373877896127 0.483518278729765 no 1746 0.48708694699228 559 24207482
SGTC_2057 5236571 38.335 µM -0.0324265887130483 0.483502166354473 no 1747 0.487065929453519 572 54684039 YBR257W POP4
SGTC_80 0159-0065 512.242 µM -0.0356878588690395 0.482505331263328 no 1748 0.485765625802628 562 1548079
SGTC_1437 4092-1038 11.6 µM -0.0359097351519721 0.482437516784279 no 1749 0.485677166673263 565 3977136
SGTC_1800 st050079 29.0735 µM -0.0365015353431594 0.482256640898991 no 1750 0.485441227249942 563 3645560
SGTC_519 k048-0011 62.8 µM -0.0369515527971105 0.482119101470757 no 1751 0.485261817300537 569 6836379
SGTC_3100 9120536 49.47 µM -0.0371158492729212 0.482068887851518 no 1752 0.485196317421672 568 16421196
SGTC_955 1216-0110 33 µM -0.037462884843677 0.481962824966402 no 1753 0.485057966482109 562 3619719
SGTC_1946 st076057 65.1 µM -0.0375874922404099 0.481924742092034 no 1754 0.485008290310946 562 953009
SGTC_299 1273-0059 1.44 µM -0.0380236563567064 0.48179144164983 no 1755 0.48483441030954 567 2848077
SGTC_1121 fusaric acid 630.51 nM -0.0405824661050845 0.481009459909302 no 1756 0.483814381330797 574 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_790 1575-0012 79.1 µM -0.0417893420561204 0.480640659321809 no 1757 0.483333315699664 602 378741 YLR208W SEC13
SGTC_1107 amlodipine 47 µM -0.042898068177983 0.480301866234134 no 1758 0.482891394352659 571 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1009 4106-0057 9.87 µM -0.0471109521548996 0.479014668448684 no 1759 0.481212399236815 570 2928005
SGTC_3291 9121177 71.43 µM -0.0472448786294732 0.478973752287335 no 1760 0.481159029730485 568 17015612
SGTC_37 0566-0070 1.56 µM -0.0516185427832021 0.477637669145186 no 1761 0.479416322015705 577 1626686
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0525939374616246 0.477339735704423 no 1762 0.479027723745881 590 6710655
SGTC_2356 9061756 188.97 µM -0.0533217474040198 0.477117435043634 no 1763 0.478737776462729 578 20104043
SGTC_2941 9056145 11.23 µM -0.0539982612877572 0.476910808521549 no 1764 0.478468274756871 574 2119517
SGTC_1907 st060210 83.7 µM -0.0543507703182372 0.476803144725006 no 1765 0.478327850216841 583 688793
SGTC_942 3253-1115 227 µM -0.0555497629584685 0.476436959452596 no 1766 0.477850243007009 572 46497897
SGTC_1678 st019265 80.2 µM -0.0563504426116326 0.476192434319939 no 1767 0.47753131762392 577 5367020
SGTC_599 1935-0052 86.5 µM -0.0574004191723004 0.475871788270602 no 1768 0.477113114551634 584 9557311
SGTC_587 k089-0003 57 µM -0.0574991673410209 0.475841632959745 no 1769 0.477073784689306 573 9659696
SGTC_733 4069-0007 56.1 µM -0.0577073605749936 0.475778056217226 no 1770 0.476990865289035 562 5717425 YNL287W SEC21
SGTC_2985 9022375 71.43 µM -0.0582272378278495 0.475619302062173 no 1771 0.476783812437274 611 4939335
SGTC_419 nsc-638432 893 µM -0.0590601062741101 0.475364978322403 no 1772 0.476452116864133 594 368090
SGTC_1337 1486-1011 40.3 µM -0.0601974981532129 0.475017681894159 no 1773 0.475999169143864 573 X1337
SGTC_2925 9010536 32.5 µM -0.061323304174901 0.474673941835899 no 1774 0.475550865839134 568 2994177
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0633536907410747 0.47405405587442 no 1775 0.474742431282024 581 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1440 4100-1550 40 µM -0.0643553087727017 0.473748280521272 no 1776 0.474343657326198 588 742806
SGTC_927 2425-1185 123 µM -0.0656617372704578 0.47334947547214 no 1777 0.473823567937926 595 730375
SGTC_2122 5258151 111.688 µM -0.0660198524473134 0.473240160596247 no 1778 0.473681009983599 589 2173356
SGTC_2608 thymoquinone 42.66 µM -0.0679252992135845 0.472658555895759 no 1779 0.472922549699523 574 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3172 9105863 49.47 µM -0.068113890760673 0.472600994734562 no 1780 0.47284748640515 579 2348785
SGTC_719 2810-4230 27.3 µM -0.069172442109134 0.472277918559575 no 1781 0.472426179281251 572 721079
SGTC_3230 9131665 49.47 µM -0.0702877647485645 0.471937535184675 no 1782 0.471982310368934 573 15943720
SGTC_3001 9076041 71.4286 µM -0.0714915085158336 0.471570189723824 no 1783 0.471503291244785 590 16004211
SGTC_264 promethazine 12.5 mM -0.0716641945486199 0.471517493250523 no 1784 0.471434575738942 574 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_945 3381-0768 11.3 µM -0.0735974170686986 0.470927589756617 no 1785 0.470665363223782 582 1126236 YIL048W NEO1
SGTC_1318 1280-3875 124 µM -0.0737893362815135 0.470869030989858 no 1786 0.470589006153933 590 373245
SGTC_332 4112-0506 40.9 µM -0.0749751339254238 0.470507232103469 no 1787 0.470117248223661 575 2790355
SGTC_1287 0971-0001 34.6 µM -0.0770360077157198 0.469878496704184 no 1788 0.469297450026171 584 4665869
SGTC_713 1488-1073 324 µM -0.078455719063487 0.469445411983505 no 1789 0.468732776334527 592 3312542
SGTC_735 3076-0345 636 µM -0.0800148334106418 0.468969843867661 no 1790 0.468112729221138 578 2888990
SGTC_1569 carminic acid 40.6 µM -0.0801557476281822 0.468926863746421 no 1791 0.468056692570177 572 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_67 0335-0847 266 µM -0.0802375461456606 0.468901914618814 no 1792 0.468024164453784 638 4552207 YOR254C SEC63
SGTC_627 1391-0720 175 µM -0.0817152403867291 0.468451228526814 no 1793 0.46743657940763 595 997839
SGTC_807 1315-0151 48 µM -0.0821762169054935 0.468310642257541 no 1794 0.467253292814032 616 4011080
SGTC_3099 9120367 49.47 µM -0.0822799154997521 0.468279017332634 no 1795 0.467212062684096 571 24824940
SGTC_1921 5740136 50 µM -0.0830442081693591 0.468045937445696 no 1796 0.466908193976381 590 1774243
SGTC_878 0828-0289 13.7 µM -0.0832188192851281 0.467992689301176 no 1797 0.466838774508387 578 745350 YLR208W SEC13
SGTC_670 4204-0025 119 µM -0.0833753562404878 0.46794495340884 no 1798 0.466776541572096 582 719039
SGTC_3241 9133421 49.47 µM -0.0834848122342695 0.467911575113827 no 1799 0.466733026656698 585 17018221
SGTC_2237 6667747 47.222 µM -0.0836948645737102 0.467847520880455 no 1800 0.46664952014865 610 729940 YDL015C TSC13
SGTC_2831 7999036 19.48 µM -0.0841332247299893 0.46771384819592 no 1801 0.46647525438304 600 2988270
SGTC_1590 st077108 57.8 µM -0.0848031983265909 0.467509554803253 no 1802 0.46620892540281 581 5489485
SGTC_1248 0469-0687 58.6 µM -0.0872203827828293 0.466772560242638 no 1803 0.465248168989177 602 4017482
SGTC_829 1635-0120 117 µM -0.0878383618034586 0.466584157895743 no 1804 0.46500257363861 580 285054
SGTC_881 0833-0569 170 µM -0.0891962164545148 0.466170217121953 no 1805 0.464462986113063 584 5418700
SGTC_1458 k015-0034 6.33 µM -0.0897180372382863 0.466011150232783 no 1806 0.46425564105148 623 3598957
SGTC_2107 5363541 170.161 µM -0.090488529123546 0.465776290742638 no 1807 0.463949504495322 586 244052
SGTC_1045 1348-1485 165 µM -0.0932317391655628 0.464940209354702 no 1808 0.462859729992577 589 6810614
SGTC_808 0711-0032 135 µM -0.0942354228168759 0.464634342993437 no 1809 0.46246107331258 590 4252555
SGTC_2592 piperlongumine 83.33 µM -0.096438322301791 0.463963096567195 no 1810 0.461586228576525 597 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_153 4077-0274 519.67 µM -0.0966568044461129 0.46389652834078 no 1811 0.461499472102838 578 3121976
SGTC_3221 9128209 49.47 µM -0.0970422852164851 0.463779080608333 no 1812 0.461346407074494 593 16460723
SGTC_1235 benzylparaben 21.5 µM -0.0976255038496354 0.463601392389214 no 1813 0.46111483604733 612 7180
SGTC_3007 9078383 71.4286 µM -0.0991944950940839 0.463123406661202 no 1814 0.460491922791044 597 6496995
SGTC_250 brefeldin a 552.239 µM -0.0991965535540692 0.463122779595965 no 1815 0.460491105614636 583 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0993994805386758 0.463060962736565 no 1816 0.460410547596292 607 77254
SGTC_1808 st050063 61.5 µM -0.0995024280097287 0.463029602589133 no 1817 0.460369680097827 596 4011993
SGTC_2190 6049624 200 µM -0.100557596115929 0.462708187601215 no 1818 0.459950829706538 593 2265554
SGTC_2020 4017018 200 µM -0.101371208162916 0.462460369670389 no 1819 0.459627895636169 593 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2238 6671620 73.2395 µM -0.101655547133698 0.462373766351061 no 1820 0.459515043767041 599 729941
SGTC_2693 st077581 40.7 µM -0.10335824562007 0.461855199767953 no 1821 0.458839324886858 622 25238761
SGTC_3045 9092950 49.47 µM -0.104148853954461 0.461614437457407 no 1822 0.458525610889581 621 44120432
SGTC_2558 carylophyllene oxide 100 µM -0.105203676311933 0.461293236518965 no 1823 0.458107096818972 582 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_451 chloral hydrate 100 µM -0.10633096500311 0.460949996978762 no 1824 0.457659882164096 612 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_998 3996-0085 177 µM -0.106395006337216 0.460930498391972 no 1825 0.457634477478112 586 715391
SGTC_2477 5967686 25.23 µM -0.109143923691314 0.46009362804413 no 1826 0.456544168446231 602 776118
SGTC_1279 0874-0590 65.2 µM -0.10951304624861 0.459981267101806 no 1827 0.456397787297921 603 3523074
SGTC_3295 9122362 53.5725 µM -0.109647789041309 0.459940252178359 no 1828 0.456344354473108 614 4730473
SGTC_1878 temozolomide 1 mM -0.109904139107291 0.459862221884618 no 1829 0.456242699949736 592 5394 DNA alkylating agent.
SGTC_797 k781-0471 270 µM -0.110419711724198 0.459705291626851 no 1830 0.456038260510407 597 23738129
SGTC_471 1-acyl-paf 4 µM -0.111241962273445 0.459455027581728 no 1831 0.455712238513324 596 16759367
SGTC_2837 9008476 45.46 µM -0.111359905180851 0.459419131238767 no 1832 0.45566547664043 632 2992805
SGTC_1523 st012844 44.7 µM -0.111921698851033 0.459248151884957 no 1833 0.455442745751405 617 4274103
SGTC_1853 st056710 91.2 µM -0.112198939197047 0.459163777819612 no 1834 0.45533283512908 626 269167
SGTC_167 3672-0051 66.205 µM -0.113202251003113 0.458858449870912 no 1835 0.454935105549361 606 3237971
SGTC_248 streptozotocin 5.23457 mM -0.113345960418343 0.458814718190208 no 1836 0.454878140422827 611 5300 DNA alkylating agent.
SGTC_319 1348-1596 45.5 µM -0.113512917029156 0.458763912867317 no 1837 0.454811961481199 620 5380505
SGTC_1127 asiatic acid 681.4 nM -0.11502543793345 0.458303679686782 no 1838 0.454212479653795 609 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2800 7887935 81.82 µM -0.116944150393825 0.457719930150197 no 1839 0.453452155602457 612 2961002
SGTC_2543 pimpinellin 60.67 µM -0.117746866355681 0.457475738639249 no 1840 0.453134115530814 601 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1459 k035-0031 35.7 µM -0.117883005159587 0.457434325903244 no 1841 0.453080179632741 588 3877128 YMR208W ERG12
SGTC_2378 9074213 121.43 µM -0.118314515668493 0.457303065643863 no 1842 0.452909228171276 581 657714
SGTC_2425 5628681 7.85 µM -0.118592743052872 0.457218434719291 no 1843 0.452799007490909 590 5714958
SGTC_2813 7971799 71.43 µM -0.119383406287877 0.456977942178989 no 1844 0.452485803567344 621 2234054
SGTC_474 dl-dihydrosphingosine 5 µM -0.120655213406667 0.456591135321889 no 1845 0.451982067135177 619 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1451 4152-0210 104 µM -0.122191128595668 0.456124057612612 no 1846 0.451373826081405 648 659563
SGTC_2188 6126565 140.678 µM -0.12270147455001 0.455968872834377 no 1847 0.451171748084672 610 874518
SGTC_623 k072-0108 16.9 µM -0.124072791032838 0.455551919532743 no 1848 0.450628820640252 625 5382803
SGTC_3326 9140064 16.379 µM -0.124145419993146 0.455529837818656 no 1849 0.450600068170265 619 1868434
SGTC_2699 st077704 54.6 µM -0.12559628255776 0.455088754328158 no 1850 0.450025752871553 613 645852
SGTC_446 go6976 132 µM -0.125761439763525 0.455038547615851 no 1851 0.449960382987748 598 3501 A protein kinase C inhibitor.
SGTC_1611 st001856 99.4 µM -0.126101834677016 0.454935072050788 no 1852 0.449825657601969 629 647478
SGTC_512 prima-1 270 µM -0.126530848683283 0.454804661806314 no 1853 0.449655865778777 599 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2473 5854593 8.94 µM -0.127194203478988 0.454603027025067 no 1854 0.449393346536737 608 2872951
SGTC_1519 esterone 74 µM -0.127883300665823 0.454393579917512 no 1855 0.44912066333268 609 698 A steroid.
SGTC_360 0957-0399 1.01 µM -0.128708635952478 0.454142740720356 no 1856 0.448794100875661 631 6752301 YPR165W RHO1
SGTC_3354 9151612 71.43 µM -0.129676532101236 0.453848597164177 no 1857 0.4484111752185 615 27261949
SGTC_38 0929-0051 58.268 µM -0.131722882613882 0.453226794946611 no 1858 0.447601742757677 629 1379719
SGTC_1654 st012436 41.8 µM -0.131930318153755 0.453163770146031 no 1859 0.447519703902476 620 4323132
SGTC_2623 humulene 100 µM -0.13250455715702 0.452989306207619 no 1860 0.447292609359527 616 6187145 An anti-inflammatory.
SGTC_682 0kpi-0099 17 µM -0.132506645327261 0.452988671801204 no 1861 0.447291783581439 618 1714895 YML126C ERG13
SGTC_221 trifluoperazine 10.304 µM -0.134473660111046 0.452391127108186 no 1862 0.446514019040096 603 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1820 st053765 18.6 µM -0.135403862435825 0.452108585374785 no 1863 0.44614628523792 611 3690829
SGTC_1195 1502-0147 41.1 µM -0.137607663912218 0.451439294839304 no 1864 0.44527524911537 617 817940
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.1388186568835 0.45107157709185 no 1865 0.444796725334962 644 689007
SGTC_2721 ifenprodil 61.44 µM -0.141693301319763 0.450198860641287 no 1866 0.443661133163697 620 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1461 k072-0203 53.8 µM -0.142626555847393 0.449915584444511 no 1867 0.443292561680216 613 5418714
SGTC_324 1315-0088 19.6 µM -0.14375491177451 0.449573122071743 no 1868 0.442847004075432 635 6787421
SGTC_1499 4480-0877 67.3 µM -0.144000180718932 0.44949868652723 no 1869 0.442750163465442 585 2861909
SGTC_1963 st076565 50.3 µM -0.145851605256636 0.448936863722478 no 1870 0.442019268172134 607 4914280
SGTC_161 4065-0411 162.148 µM -0.14771321568336 0.448372053184533 no 1871 0.441284550724426 647 1906281 YLR208W SEC13
SGTC_2370 9071495 200 µM -0.147853500417064 0.44832949517729 no 1872 0.441229193029369 650 21791103
SGTC_2692 st077426 47.7 µM -0.14838110776018 0.448169440913948 no 1873 0.441021004423824 627 25238571
SGTC_3246 9135460 32.98 µM -0.150158475629194 0.447630323190259 no 1874 0.440319793012881 600 41446951
SGTC_1423 4048-0112 5.59 µM -0.150165894623973 0.447628073035667 no 1875 0.440316866444021 621 X1423
SGTC_2065 5221596 34.26 µM -0.150306961123124 0.447585288391596 no 1876 0.440261220600891 606 788581
SGTC_936 3005-4620 401 µM -0.150697740618356 0.447466770442641 no 1877 0.440107077802992 621 777207
SGTC_2489 cantharidin 73.42 µM -0.151142939845164 0.44733175346741 no 1878 0.439931480228776 611 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_71 0417-1750 47.813 µM -0.151972901989986 0.447080064533675 no 1879 0.439604154224854 598 6811472
SGTC_2175 5807670 165.306 µM -0.152646934519969 0.446875677480115 no 1880 0.439338355149772 615 241186
SGTC_2784 7567673 72.73 µM -0.153843782429883 0.446512791791739 no 1881 0.438866455679276 614 3471247
SGTC_1134 3477-0009 42.5 µM -0.154203919410091 0.446403606589612 no 1882 0.438724475956813 593 3973534
SGTC_2890 9046729 58.44 µM -0.154289175174771 0.446377759608313 no 1883 0.438690866038793 623 903329
SGTC_2928 9011484 9.79 µM -0.15534366508661 0.446058088880916 no 1884 0.438275196821715 649 2994751
SGTC_3262 9137218 49.47 µM -0.15576919358974 0.445929098980095 no 1885 0.438107477061735 605 17650664
SGTC_2132 5317594 122.667 µM -0.157402206378826 0.445434139177688 no 1886 0.437463937346752 610 794577
SGTC_2288 7946289 167.31 µM -0.160275747421504 0.444563387046892 no 1887 0.436331931320668 642 1246052
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.160835427757249 0.444393821418244 no 1888 0.436111510575607 599 688803
SGTC_2798 7813637 45.45 µM -0.16102059973788 0.444337722341381 no 1889 0.436038588050995 615 956368
SGTC_3327 9140648 26.9345 µM -0.161351226519192 0.44423755954388 no 1890 0.435908389421525 637 8029710
SGTC_1672 st016598 6.51 µM -0.16180014390872 0.444101566517935 no 1891 0.435731619856703 662 4665860 YNL267W PIK1
SGTC_44 0929-0055 61.211 µM -0.16233397795586 0.443939857787275 no 1892 0.435521429494533 605 1379590
SGTC_3113 9123498 49.47 µM -0.16272774673168 0.44382058353516 no 1893 0.4353663997198 603 8897275
SGTC_2479 5617353 43.85 µM -0.16376086651528 0.443507671336459 no 1894 0.434959699850681 623 2731746
SGTC_620 0109-0052 432 µM -0.163831608701614 0.443486246169169 no 1895 0.434931853861171 622 493037
SGTC_543 3844-1095 191 µM -0.164849700324858 0.443177922551821 no 1896 0.434531141969014 619 4230703
SGTC_912 3474-0017 2.18 µM -0.164887150714433 0.443166581555977 no 1897 0.434516403105519 641 3360550
SGTC_3199 9111318 49.47 µM -0.165207834782576 0.44306947161133 no 1898 0.434390199369669 622 8548020
SGTC_656 4090-1979 187 µM -0.166117303032995 0.442794083935152 no 1899 0.434032318745616 623 22330961
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.167356669781438 0.442418847258422 no 1900 0.433544708390314 631 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.167905975365801 0.442252553340267 no 1901 0.433328624604222 625 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2705 st078069 42.8 µM -0.170931359873972 0.441336847283673 no 1902 0.43213886895715 654 1530061
SGTC_1843 st055809 45.5 µM -0.17210363940627 0.44098211243145 no 1903 0.431678025812278 625 16413835
SGTC_2172 5754775 163.918 µM -0.173460936859294 0.440571449836868 no 1904 0.431144565131465 624 2263357
SGTC_844 0330-0132 15.3 µM -0.173520670922525 0.440553378221876 no 1905 0.431121090639856 632 2828079
SGTC_1709 st033179 39.1045 µM -0.173538480088809 0.440547990358605 no 1906 0.431114091981309 626 573381
SGTC_1229 0139-0193 12.2 µM -0.174742471066372 0.440183768744384 no 1907 0.430640997041041 614 3090752
SGTC_675 1309-0189 238 µM -0.175356184217297 0.439998132659026 no 1908 0.430399883497852 611 4246530
SGTC_755 1995-0008 37.3 µM -0.17628546367344 0.439717069129589 no 1909 0.430034840752101 609 689533
SGTC_265 mycophenolic acid 32.932 µM -0.177044889243624 0.439487401000885 no 1910 0.429736564979491 628 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3077 9117319 49.47 µM -0.178086957351448 0.439172288291585 no 1911 0.429327342414307 620 17154678
SGTC_1888 azatryptophan 97.5 µM -0.178104647816845 0.439166939174467 no 1912 0.429320395981757 633 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_188 3229-0966 278.469 µM -0.179619859407734 0.438708821593415 no 1913 0.428725506351213 627 5722370
SGTC_3011 9081274 71.4286 µM -0.179666290586099 0.438694784623579 no 1914 0.428707279482094 615 6625322
SGTC_73 0327-0325 16.231 µM -0.181102913996739 0.438260506040984 no 1915 0.428143398690577 638 53298
SGTC_465 cgp-37157 41 µM -0.182099444380521 0.437959307332251 no 1916 0.427752342381607 633 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1575 cyproterone acetate 48 µM -0.182984371598864 0.437691870510902 no 1917 0.427405140617532 656 9880 An androgen receptor antagonist and liver toxin.
SGTC_315 k915-0449 187 µM -0.183171336912426 0.437635370734366 no 1918 0.427331791840918 632 20970215 YNL149C PGA2
SGTC_426 0988-0037 14.6 µM -0.184134880644673 0.437344213887137 no 1919 0.426953821748085 639 5383008
SGTC_1345 1488-0192 31.4 µM -0.185702289505406 0.436870657887765 no 1920 0.426339116393896 657 658348
SGTC_760 0568-0725 82.9 µM -0.186066422476983 0.436760656532289 no 1921 0.42619633652412 650 3916171
SGTC_1952 st077036 64.1 µM -0.187374741964292 0.436365465172565 no 1922 0.425683412430488 641 2937007
SGTC_2846 9008642 19.48 µM -0.18742629744883 0.436349893606222 no 1923 0.425663202772938 688 2992898
SGTC_16 erodoxin 22.806 µM -0.187461874359717 0.436339148187619 no 1924 0.425649256801497 648 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2789 5281112 71.43 µM -0.190328359127604 0.43547352885479 no 1925 0.424525916213764 638 765948
SGTC_1218 1348-1416 30.7 µM -0.191294999989816 0.43518169271598 no 1926 0.424147239094684 636 6787668
SGTC_680 0417-1641 114 µM -0.191911845957367 0.434995480726016 no 1927 0.423905629093457 622 2835990
SGTC_3079 9117512 49.47 µM -0.19226439152684 0.434889061581697 no 1928 0.423767554726897 638 7185044
SGTC_524 r073-0010 27.8 µM -0.192609643038573 0.434784848787457 no 1929 0.423632346145949 656 2772106
SGTC_15 0266-0086 27.098 µM -0.194618563526045 0.434178554241266 no 1930 0.422845784672423 631 1712902 YIL048W NEO1
SGTC_2445 5742597 35.57 µM -0.196080922553578 0.433737309852744 no 1931 0.422273414004088 630 1774255
SGTC_1208 2323-2347 50.3 µM -0.196478198408046 0.433617452200973 no 1932 0.422117947622222 660 5412760
SGTC_2295 7971645 200 µM -0.197651572125892 0.433263482429518 no 1933 0.42165884097723 651 2978226 YKL099C UTP11
SGTC_3006 9075424 71.4286 µM -0.198701673985328 0.432946745262539 no 1934 0.421248057242505 630 7465181
SGTC_2364 9055074 200 µM -0.199359851554034 0.432748244277787 no 1935 0.420990631941877 650 6470630
SGTC_3347 9188721 44.724 µM -0.199672387594939 0.432653991897004 no 1936 0.420868405193209 657 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_114 0364-0001 490.298 µM -0.199809228241005 0.432612725680819 no 1937 0.42081489188619 641 4003655
SGTC_1472 k841-0093 193 µM -0.200294426319939 0.432466413320758 no 1938 0.420625160690994 656 X1472
SGTC_1822 st052468 42 µM -0.200589903135424 0.432377316286902 no 1939 0.420509626870205 634 2873678
SGTC_2624 nerol 100 µM -0.201018191809611 0.432248177740392 no 1940 0.420342174698682 636 637566 A natural product oil.
SGTC_2192 5915882 198.485 µM -0.202019868222588 0.431946178340245 no 1941 0.419950595905343 635 2876149
SGTC_809 3998-0021 90 µM -0.20486728624488 0.431087916729629 no 1942 0.418837907443119 637 715485
SGTC_2354 9060492 162 µM -0.205495767728875 0.43089852509822 no 1943 0.418592402203785 663 6471895
SGTC_2426 5582046 32.21 µM -0.206154370815725 0.430700073433641 no 1944 0.418335164512358 656 2251934
SGTC_54 0159-0055 9 µM -0.206532596616548 0.430586113548436 no 1945 0.418187452573452 704 3319099
SGTC_1767 st044992 70.3 µM -0.207640332094606 0.430252384817164 no 1946 0.417754905086576 644 9600693
SGTC_2635 hydroquinidine 100 µM -0.212543809850175 0.428775709997765 no 1947 0.415841401558935 626 442912 An experimental heart treatment.
SGTC_2412 st077135 33.4 µM -0.213171655694057 0.428586706712512 no 1948 0.415596537814978 703 13258915
SGTC_1500 4488-1866 171 µM -0.213303116977298 0.428547134397614 no 1949 0.415545271251333 667 2900003
SGTC_1040 k898-0338 155 µM -0.214567241501675 0.428166645901762 no 1950 0.415052368271711 663 20969351
SGTC_552 k242-0005 476 µM -0.215350580454741 0.427930902410309 no 1951 0.414746998542836 664 4088318
SGTC_1914 st062367 72.6 µM -0.215412258897039 0.427912341560748 no 1952 0.414722956565383 659 978205
SGTC_488 nitrendipine 139 µM -0.217062235923243 0.427415874489724 no 1953 0.414079921839791 623 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3085 9117376 49.47 µM -0.218521006825875 0.426977035753838 no 1954 0.413511596350113 643 16480349
SGTC_2908 7930301 100 µM -0.219678045143718 0.426629030775896 no 1955 0.413060952220933 657 2223178
SGTC_111 0083-0039 52.457 µM -0.222550978932221 0.425765179629575 no 1956 0.41194249633633 628 759313
SGTC_3289 9119912 71.43 µM -0.222794680241874 0.425691918372252 no 1957 0.411847654255196 706 17014829
SGTC_1424 4048-1941 275 µM -0.224531167557398 0.425169971600202 no 1958 0.411172008868028 664 X1424
SGTC_1231 0242-0792 125 µM -0.22573777101483 0.424807372469264 no 1959 0.410702689601359 670 3707635
SGTC_3202 9113761 49.47 µM -0.22619310094281 0.424670556759435 no 1960 0.410525618112642 676 4798415
SGTC_2087 5276107 200 µM -0.226433353496921 0.424598370292249 no 1961 0.410432194576639 630 144405
SGTC_504 lovastatin 124 µM -0.227082525202421 0.424403332317013 no 1962 0.410179785997672 683 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1460 k062-0059 9.15 µM -0.227366401487339 0.424318049977879 no 1963 0.41006942194047 618 1373085
SGTC_2536 dehydroabietamide 32.04 µM -0.22924105491403 0.423754954249879 no 1964 0.409340782427793 664 3983547
SGTC_1047 2043-3044 82 µM -0.230141833202657 0.42348443984774 no 1965 0.408990779503418 716 669592
SGTC_901 1112-0062 60.1 µM -0.231711703383796 0.423013075475495 no 1966 0.408380970382801 639 1908457
SGTC_2853 9015042 58.44 µM -0.232536364880618 0.422765509262374 no 1967 0.408060723037389 636 6457456
SGTC_3198 9112019 49.47 µM -0.232680830515909 0.422722143319435 no 1968 0.40800462786544 688 45595555
SGTC_3211 9128781 49.47 µM -0.233465031446927 0.422486756887792 no 1969 0.407700160099044 681 17194361
SGTC_3145 9085516 49.47 µM -0.233550906808642 0.422460982144661 no 1970 0.407666822180528 641 25236195
SGTC_1553 gossypol 38.6 µM -0.234623354685657 0.42213912423755 no 1971 0.407250540528542 638 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2265 7929201 200 µM -0.23795713390271 0.421138939369449 no 1972 0.405957170741683 688 1265108
SGTC_1865 st057639 52.2 µM -0.237971012094614 0.42113477675797 no 1973 0.405951788705921 641 688818
SGTC_1425 4048-4433 7.33 µM -0.238307563169843 0.421033834653557 no 1974 0.405821277874398 669 23734946
SGTC_1233 0325-0408 14.2 µM -0.238672341626263 0.420924432144405 no 1975 0.405679832593698 672 12874
SGTC_694 1315-0438 43.2 µM -0.239521173037903 0.420669878572463 no 1976 0.405350740246307 685 6793154
SGTC_1873 rapamycin 2 nM -0.239692665500966 0.420618454222829 no 1977 0.405284260652119 648 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.241091856405671 0.420198938473674 no 1978 0.404741962148943 638 17037758
SGTC_2551 apiole 73.87 µM -0.241146123878037 0.420182669422317 no 1979 0.404720932836506 644 10659 A possible DNA adduct former.
SGTC_1128 3448-9350 235 µM -0.241883653136625 0.419961576261327 no 1980 0.404435158494661 643 619386
SGTC_208 k072-0098 12.366 µM -0.244789018044695 0.419090865573769 no 1981 0.403309898803049 665 5948901
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.244989839967858 0.419030695709615 no 1982 0.403232149109469 671 688667
SGTC_327 1273-0057 3.96 µM -0.245368379603263 0.418917283569191 no 1983 0.403085605091439 657 3108138
SGTC_2045 5106652 78.05 µM -0.247469403532181 0.418287930290062 no 1984 0.402272483831979 636 673349
SGTC_3151 9099821 49.47 µM -0.250261989723968 0.417451746295217 no 1985 0.40119237456252 695 17174189
SGTC_649 1123-0311 367 µM -0.252004485764619 0.416930179579159 no 1986 0.400518798269998 673 693629 YIL048W NEO1
SGTC_2150 5556613 200 µM -0.252345252870484 0.416828197680815 no 1987 0.400387106429732 643 743190
SGTC_2822 7994718 71.43 µM -0.253826996400463 0.41638481916969 no 1988 0.3998146080976 668 1018011
SGTC_347 4534-1311 26.2 µM -0.255099627804415 0.416004097660675 no 1989 0.399323075813352 660 2862016
SGTC_1761 st044296 37 µM -0.255926373442814 0.41575680992916 no 1990 0.399003844784293 670 1826700
SGTC_749 1000-0129 128 µM -0.256100434590455 0.415704750779491 no 1991 0.398936643208618 700 708470
SGTC_1098 clofazimine 15.1 µM -0.256163737288869 0.415685818232792 no 1992 0.398912204028155 647 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1036 k216-0215 33.5 µM -0.256298045812808 0.415645649939271 no 1993 0.398860353044685 657 622330
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.258879379551913 0.414873809834382 no 1994 0.39786415434774 657 6857784
SGTC_2185 6113692 200 µM -0.260380598324004 0.414425083898439 no 1995 0.397285103620498 664 874150
SGTC_3022 9087993 49.47 µM -0.260401750605075 0.414418762113956 no 1996 0.397276946367772 638 17173644
SGTC_79 0052-0007 94.094 µM -0.261276447376089 0.414157360829661 no 1997 0.396939664090357 659 2801472
SGTC_88 0180-0332 8.668 µM -0.262559168336255 0.413774091173142 no 1998 0.396445187512449 649 3101745
SGTC_155 k072-0202 43.6 µM -0.262716464939797 0.41372709749691 no 1999 0.396384562632316 636 5857737
SGTC_2879 9041815 71.43 µM -0.263362846838594 0.413533998475051 no 2000 0.396135461984219 649 4942971
SGTC_1626 st003712 1.76 µM -0.263389610208388 0.413526003682269 no 2001 0.396125148913405 698 24207035
SGTC_2032 5185112 25.99 µM -0.263500823363506 0.413492782310729 no 2002 0.396082294507925 641 5718189
SGTC_1777 st045864 34.765 µM -0.264731886132572 0.413125083118597 no 2003 0.395608006002001 652 4691462
SGTC_3086 9117350 49.47 µM -0.265075169535224 0.413022563308093 no 2004 0.395475777582809 645 2679265
SGTC_2946 9065502 71.43 µM -0.269426745550275 0.411723504088922 no 2005 0.393800653438088 645 16489101
SGTC_1555 citronellol 128 µM -0.269454862074396 0.411715113700237 no 2006 0.393789836429724 661 8842 A terpine precursor.
SGTC_1898 st060199 18.6 µM -0.270044643036976 0.411539123605306 no 2007 0.39356295439605 645 688866
SGTC_2449 5812982 45.77 µM -0.272511265991101 0.410803278838759 no 2008 0.392614464974297 658 776185
SGTC_2355 9061122 103.12 µM -0.273008509474551 0.410654978720815 no 2009 0.392423337178634 692 5302957
SGTC_385 1494-0393 12.4 µM -0.273180007094821 0.410603833465451 no 2010 0.392357423853774 687 3090647
SGTC_1247 0448-0043 5.84 µM -0.276324244127638 0.40966640672723 no 2011 0.391149518212972 699 3089013 YGL099W LSG1
SGTC_877 0771-0151 33.1 µM -0.27681909330773 0.409518918652115 no 2012 0.39095950976335 684 6166523
SGTC_2162 5663267 200 µM -0.277082555404784 0.409440399913454 no 2013 0.390858358192034 710 6456493
SGTC_3092 9117248 49.47 µM -0.277181614906814 0.409410878476724 no 2014 0.390820327973423 669 17141857
SGTC_3168 9103419 49.47 µM -0.278250644855444 0.409092321868929 no 2015 0.390409980119316 673 16649256
SGTC_1976 st070609 63.5 µM -0.284398622120532 0.407261478509786 no 2016 0.388052457406951 647 682556
SGTC_1812 st052057 4.327 µM -0.286173847745795 0.406733198198664 no 2017 0.387372486485348 667 3645418
SGTC_22 0964-0034 14.468 µM -0.287135798047449 0.40644700715041 no 2018 0.387004171420811 680 138402
SGTC_571 k831-0106 44.2 µM -0.291756561812044 0.405072976958778 no 2019 0.385236379766673 704 4783639
SGTC_3163 9099914 49.47 µM -0.2927959048066 0.404764078444297 no 2020 0.384839079321286 669 16268368
SGTC_2986 9022445 71.43 µM -0.29466665118881 0.404208231869039 no 2021 0.384124270540972 710 6459286
SGTC_1651 st011928 86.1 µM -0.295047095987374 0.404095215613084 no 2022 0.383978951404647 669 720198
SGTC_2156 5649887 115 µM -0.29714353302545 0.403472584553294 no 2023 0.38317846494588 682 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_641 4092-0595 30 µM -0.298013078984407 0.403214405528332 no 2024 0.382846590672306 672 786260
SGTC_1505 k297-0037 20.6 µM -0.298804219750359 0.402979542627223 no 2025 0.382544715530714 669 4089396
SGTC_3056 9094900 49.47 µM -0.300035576767112 0.402614064089028 no 2026 0.382075009337969 683 25236784
SGTC_1969 st069479 40.1 µM -0.301540599211281 0.402167474625558 no 2027 0.38150114803529 697 3895485
SGTC_970 1315-0089 19.5 µM -0.302153988389273 0.401985498551986 no 2028 0.381267338889326 650 6811083 YLR033W RSC58
SGTC_557 1315-0110 16.2 µM -0.302293292749348 0.401944173653615 no 2029 0.381214245465166 665 6833801
SGTC_750 4073-0104 132 µM -0.302803115435536 0.401792943153096 no 2030 0.381019954522483 699 22330957
SGTC_3005 9076496 71.4286 µM -0.303533674667883 0.401576260430841 no 2031 0.380741594249324 690 21368410
SGTC_2465 5809242 33.21 µM -0.30376585131882 0.401507403533488 no 2032 0.380653142395105 697 2731748
SGTC_234 nsc-17383 10.7 µM -0.304578836532081 0.401266319685992 no 2033 0.380343470307439 681 408974
SGTC_178 4092-0806 87.505 µM -0.305198285307841 0.401082652645757 no 2034 0.380107569137416 652 2169044
SGTC_3183 9108214 49.47 µM -0.305264149631648 0.401063125107853 no 2035 0.380082489021318 695 4974831
SGTC_1174 0739-0097 51.1 µM -0.306528357126965 0.400688359229909 no 2036 0.379601196197385 685 728447
SGTC_1141 3253-0389 52.6 µM -0.307616448981182 0.400365874826049 no 2037 0.379187101145896 707 5402031
SGTC_65 0798-0905 34.986 µM -0.308054800614726 0.400235977063512 no 2038 0.379020316826314 770 3602145
SGTC_55 0767-0285 6.563 µM -0.31034074222345 0.399558757793813 no 2039 0.378150925849388 693 3116166
SGTC_1077 5-fluorocytosine 377 nM -0.312488164089865 0.398922850667173 no 2040 0.377334778362672 710 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_307 1501-1223 22.3 µM -0.312611387982307 0.398886369007483 no 2041 0.377287962562828 705 2830329
SGTC_1457 k015-0032 57.3 µM -0.315244140707029 0.3981071279039 no 2042 0.376288146697825 696 4302660
SGTC_123 0083-0120 66.675 µM -0.316211351799583 0.397820955015833 no 2043 0.375921045998761 684 16001701
SGTC_2942 9052777 62.25 µM -0.317184172692329 0.397533177780141 no 2044 0.375551929361988 677 6469503
SGTC_2112 5488546 200 µM -0.317382066128445 0.397474644301002 no 2045 0.375476856745814 715 600757
SGTC_247 mechlorethamine 29.705 µM -0.318269468026187 0.397212194467211 no 2046 0.37514027104296 668 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1887 st057648 70.8 µM -0.318508709188313 0.397141446657876 no 2047 0.375049544700636 691 688672
SGTC_1300 1094-0077 113 µM -0.320029341059558 0.3966918483465 no 2048 0.374473044171648 676 5532636
SGTC_1486 3970-0793 4.53 µM -0.320034147276377 0.396690427531592 no 2049 0.374471222487265 696 2844330
SGTC_2145 5634607 200 µM -0.322405411974669 0.39598960136008 no 2050 0.373572792390703 709 308662
SGTC_3109 9122853 49.47 µM -0.322845093339454 0.395859690604777 no 2051 0.373406280249586 704 1234709
SGTC_3133 9127736 49.47 µM -0.323420988534805 0.395689550836142 no 2052 0.373188218197481 691 27243420
SGTC_1642 st009582 77.7 µM -0.325149140637863 0.395179113133583 no 2053 0.372534099439578 717 6739311
SGTC_865 0488-0499 301 µM -0.327053260453626 0.394616908749115 no 2054 0.371813801106915 708 9634651
SGTC_1112 tnp00069 1.16933 µM -0.327249054437436 0.394559111658718 no 2055 0.371739760733666 698 145826
SGTC_1564 D-Arginine 115 µM -0.328519741676182 0.394184069645147 no 2056 0.371259360064341 734 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1688 st021091 57.6 µM -0.332436608199216 0.393028629192149 no 2057 0.369779799743553 717 3656366
SGTC_2260 7964312 200 µM -0.332714320287068 0.392946742255929 no 2058 0.369674969410656 704 231951
SGTC_1746 st038117 42 µM -0.335665660645431 0.39207679543209 no 2059 0.36856150182668 685 2898218
SGTC_526 4469-0568 170 µM -0.337689815835805 0.391480460205338 no 2060 0.367798475092991 674 2901964
SGTC_2661 dactinomycin 12.96 µM -0.337791598335452 0.39145048084083 no 2061 0.367760120846408 683 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.338036275790301 0.39137841534725 no 2062 0.367667925525259 729 641818
SGTC_1376 2910-0861 41.3 µM -0.340481860014833 0.390658316253529 no 2063 0.366746840630523 685 1112859
SGTC_236 1509-0011 5.31 µM -0.342127616668358 0.39017393618557 no 2064 0.366127427519834 728 3107280
SGTC_1550 gossypolone 36.6 µM -0.342553308725182 0.390048673965944 no 2065 0.365967266580984 692 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2677 mitomycin C 100 µM -0.344015007955982 0.389618647936031 no 2066 0.365417499732646 683 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1257 0669-0121 16 µM -0.344079450951466 0.38959969217189 no 2067 0.365393268115825 678 4307855
SGTC_1802 st050112 57.9 µM -0.34445738973424 0.38948852760566 no 2068 0.365251167790985 684 4662563
SGTC_1730 st033808 45.1 µM -0.345102970046833 0.389298661540645 no 2069 0.365008480344491 698 1045166
SGTC_1943 st076331 65.2 µM -0.345353262364207 0.389225057329355 no 2070 0.36491440464775 705 24208415
SGTC_2266 7929956 200 µM -0.346155953123633 0.38898903447873 no 2071 0.364612757529372 698 2967153
SGTC_919 tnp00227 403.569 nM -0.346732856693008 0.388819427291404 no 2072 0.36439601184168 715 1269246 A methoxyflavone. YNL221C POP1
SGTC_993 3909-8757 62.7 µM -0.346862641531621 0.388781274021212 no 2073 0.364347256970286 677 4288324 YLR208W SEC13
SGTC_2663 amphotericin b 100 µM -0.347378000232945 0.388629782941693 no 2074 0.364153679389944 698 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_439 amiodarone 34.4 µM -0.349394772227427 0.388037110400435 no 2075 0.363396478745444 700 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3023 9089636 49.47 µM -0.349882225226971 0.387893900745843 no 2076 0.363213543581842 700 17249241
SGTC_2828 7998861 71.43 µM -0.350950542876372 0.387580091215625 no 2077 0.362812726165086 688 2988188
SGTC_1013 4112-3890 241 µM -0.350993667584793 0.387567425227411 no 2078 0.362796549547002 694 705171
SGTC_1886 st057356 49.9 µM -0.352439166729896 0.387142942672781 no 2079 0.362254466538738 674 24207747
SGTC_2628 lathosterol 100 µM -0.352604053052465 0.387094531029765 no 2080 0.362192649316328 717 6710616
SGTC_1368 1852-0141 284 µM -0.352846760799559 0.387023273731052 no 2081 0.362101662748351 721 2838987
SGTC_2810 7959871 45.46 µM -0.353126125245065 0.386941258995398 no 2082 0.361996943919787 696 2974535
SGTC_2786 7743617 45.45 µM -0.354555177650425 0.386521802334374 no 2083 0.361461430130929 707 583674
SGTC_1563 conessine 56.1 µM -0.356570989664308 0.385930344966014 no 2084 0.360706499290163 713 441082 An anti-amoebic, histamine inhibitor.
SGTC_3021 9087658 49.47 µM -0.356587903437384 0.385925383432354 no 2085 0.360700167295615 701 25237042
SGTC_3180 9109287 49.47 µM -0.357127656371431 0.385767060595191 no 2086 0.360498120521832 681 18891271
SGTC_3067 9117431 49.47 µM -0.357790746349111 0.385572586012437 no 2087 0.360249958063798 713 17150885
SGTC_785 1270-0111 65.3 µM -0.358958295703301 0.385230230817889 no 2088 0.359813144039565 674 6741994
SGTC_1140 3229-1848 2.98 µM -0.359078907656604 0.385194869414458 no 2089 0.359768030036716 724 2849525
SGTC_2801 7907800 81.82 µM -0.361064188833142 0.384612955620514 no 2090 0.359025731578062 739 6620925
SGTC_2743 auranofin 4.32 µM -0.361375548239787 0.384521715347979 no 2091 0.358909362196013 681 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3344 9148862 3.898 µM -0.363694907756726 0.383842255488913 no 2092 0.358042923175151 741 4905352
SGTC_784 4579-0127 173 µM -0.366133906450464 0.383128132187919 no 2093 0.357132578899982 737 1948547
SGTC_2033 5192550 145 µM -0.368321234272778 0.382488034080276 no 2094 0.356316860534175 677 182073
SGTC_834 0312-0008 75.7 µM -0.368584817978624 0.382410920758897 no 2095 0.356218606762866 719 6385573 YIL048W NEO1
SGTC_1723 st034307 2.5525 µM -0.368948884712553 0.382304418068826 no 2096 0.35608291251837 677 867466
SGTC_1005 4092-0690 4.4 µM -0.371740748492427 0.381487993394093 no 2097 0.355042941402835 719 1529343
SGTC_724 3910-0327 137 µM -0.372447530402128 0.38128139262854 no 2098 0.354779835514071 752 2885483
SGTC_2110 5483698 200 µM -0.373430337857499 0.38099416254684 no 2099 0.354414091770385 686 2848765 YHR062C RPP1
SGTC_4 0960-0234 25.671 µM -0.375927114772115 0.380264762969263 no 2100 0.353485540948781 686 6821112
SGTC_1366 1683-0113 21.9 µM -0.375990936124925 0.380246123992299 no 2101 0.353461817197973 707 708623
SGTC_2665 lovastatin 100 µM -0.37770830520615 0.379744672224842 no 2102 0.352823648708929 716 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1122 capsaicin 818.572 nM -0.377905846411587 0.37968700544212 no 2103 0.352750269578409 738 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3187 9109394 49.47 µM -0.378003104890193 0.379658614457198 no 2104 0.352714143722616 698 17098090
SGTC_499 genistein 192 µM -0.378404324902961 0.379541500100671 no 2105 0.352565127917759 719 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2036 5160441 105 µM -0.378436346144424 0.379532153717201 no 2106 0.352553235988341 699 134534 YIL048W NEO1
SGTC_1831 st055328 12 µM -0.379302534491754 0.379279356749431 no 2107 0.352231608891637 723 1103068
SGTC_2607 solasodine 47.35 µM -0.37988799769249 0.379108518607087 no 2108 0.352014278551322 695 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2165 5727197 32.143 µM -0.381068919758216 0.378763997457997 no 2109 0.351576054500007 717 1361712
SGTC_2196 6573537 42.6665 µM -0.381531932130821 0.378628944910906 no 2110 0.351404290708432 742 2903087
SGTC_148 3253-0744 288.01 µM -0.383244351865419 0.378129591149572 no 2111 0.350769297873259 692 6893655
SGTC_2860 9025725 38.96 µM -0.383257666027153 0.378125709441675 no 2112 0.350764362397567 734 40546248
SGTC_603 3794-0023 45.9 µM -0.384068655613101 0.377889290828946 no 2113 0.350463781193902 742 3802260
SGTC_1061 3448-9325 110 µM -0.384280748560991 0.377827469312767 no 2114 0.350385187538479 746 723482
SGTC_2989 9073649 71.4286 µM -0.385746550180788 0.377400298487471 no 2115 0.349842191954106 753 21367202
SGTC_2458 5808907 16.39 µM -0.388925635814972 0.376474350244453 no 2116 0.348665578799675 733 2731747
SGTC_374 0880-0231 82.3 µM -0.389447164911378 0.376322516090699 no 2117 0.348472693926932 720 6833587
SGTC_737 1950-0117 57.9 µM -0.389755577571826 0.376232736095137 no 2118 0.348358647508805 724 5393513
SGTC_1398 3558-0053 112 µM -0.390169955368762 0.376112119824852 no 2119 0.348205438341886 692 4532369
SGTC_1710 st031758 61.5 µM -0.391638624640844 0.375684719992898 no 2120 0.347662622386906 727 5394341
SGTC_502 l-744,832 89.3 µM -0.392806277544793 0.375345028209523 no 2121 0.347231283897077 740 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2656 pseudo-anisatin 100 µM -0.393031976463639 0.375279379364466 no 2122 0.347147932060922 720 6708809 A neurotoxin.
SGTC_1111 tnp00062 510.699 nM -0.393702826864579 0.375084271032185 no 2123 0.346900227027409 694 676306
SGTC_2324 6149169 200 µM -0.394277450916634 0.374917174322431 no 2124 0.346688104653225 733 2888231
SGTC_2459 5811157 9.22 µM -0.394517842535655 0.374847277061602 no 2125 0.346599378379678 712 2870684 YBR192W RIM2
SGTC_2821 7996764 71.43 µM -0.39924484873045 0.373473671079094 no 2126 0.344856400032918 670 2987135
SGTC_204 PMA1.184 62.41 µM -0.400579468785656 0.373086137980679 no 2127 0.34436488208056 722 2252213 YGL008C PMA1
SGTC_1278 0874-0585 172 µM -0.400810248348098 0.373019139617462 no 2128 0.344279916498304 705 766306
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.401009147544894 0.372961399627504 no 2129 0.344206694542397 709 688662
SGTC_2616 abietic acid 100 µM -0.404163075026828 0.372046203741444 no 2130 0.343046402392386 741 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1682 st012968 530 nM -0.404615147281197 0.371915082035218 no 2131 0.342880211313347 706 24207270
SGTC_1990 st072050 59.8 µM -0.405444526398093 0.371674562652146 no 2132 0.342575393511414 705 17233948
SGTC_18 0111-0177 500 nM -0.406059143634563 0.371496356373131 no 2133 0.342349572235435 748 721752
SGTC_447 ml7 120 µM -0.406818392879243 0.371276252537273 no 2134 0.342070688404183 726 4216 Selective myosin light chain kinase inhibitor.
SGTC_3136 9095672 49.47 µM -0.407446182527813 0.371094290189608 no 2135 0.341840156732076 686 17217380
SGTC_1906 st060206 94.7 µM -0.407664100108605 0.371031134375568 no 2136 0.341760148639234 754 5133468
SGTC_625 k213-0058 121 µM -0.408039256433778 0.370922416531101 no 2137 0.341622427243581 706 3655420
SGTC_1438 4092-1045 4 µM -0.408950438326952 0.370658404905787 no 2138 0.341288016516819 716 1351342
SGTC_1032 k061-1018 98.7 µM -0.409373356757238 0.370535886518521 no 2139 0.341132844535977 757 4005393
SGTC_3216 9129716 49.47 µM -0.412535775372698 0.369620158868563 no 2140 0.339973382179057 703 8056934
SGTC_1294 1000-1494 117 µM -0.41431231466848 0.369106058032084 no 2141 0.339322698143292 698 712797 YDL207W GLE1
SGTC_1263 0774-1208 64.8 µM -0.414480363060139 0.369057439733719 no 2142 0.339261172670149 772 906585
SGTC_2021 4019055 173 µM -0.414544838716876 0.36903878675377 no 2143 0.339237568135113 741 44827708 YER133W GLC7
SGTC_1852 st056254 31.4 µM -0.41715602372517 0.368283623558766 no 2144 0.338282144475538 725 442583
SGTC_2832 7992762 51.95 µM -0.419903172356597 0.367489688224743 no 2145 0.337278095091173 697 2985177
SGTC_1123 mangostin 811.285 nM -0.419945207597793 0.367477544284997 no 2146 0.337262740697796 707 5281650 An antioxidant.
SGTC_3267 9137951 49.47 µM -0.422686087988844 0.366685993204212 no 2147 0.33626215357431 724 16643986
SGTC_2261 9010538 184.68 µM -0.423988196514861 0.3663101497884 no 2148 0.335787210756412 776 6457250
SGTC_2945 9067681 61.76 µM -0.424346979670055 0.366206612357865 no 2149 0.335656390986663 764 16456930
SGTC_2842 9000675 19.48 µM -0.42513099225136 0.365980396376781 no 2150 0.33537059308871 700 2989072
SGTC_608 k048-0125 159 µM -0.426246665528412 0.365658564615264 no 2151 0.334964058395137 754 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_946 3434-1334 87.4 µM -0.426791601534602 0.365501404455433 no 2152 0.334765562079492 713 4047976
SGTC_6 0844-0013 19.835 µM -0.428584267899402 0.364984556883264 no 2153 0.334112898207549 738 1584900
SGTC_1187 1391-0724 117 µM -0.42878016095626 0.364928093371468 no 2154 0.334041608916031 725 6997986
SGTC_2808 7946468 45.46 µM -0.429539420907752 0.364709274694034 no 2155 0.333765356059002 762 2970879
SGTC_3002 9075603 71.4286 µM -0.429951533629615 0.364590522275681 no 2156 0.333615448657209 711 20105405
SGTC_770 0389-1121 67.2 µM -0.430330842813879 0.36448123384921 no 2157 0.333477497125615 717 6753108
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.430518308851726 0.364427224279672 no 2158 0.333409325631312 705 6708630 An antioxidant.
SGTC_1084 voriconazole 435 nM -0.433304822319242 0.363624738641279 no 2159 0.332396667623903 758 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3352 9151559 45.5865 µM -0.435048754818197 0.363122808986744 no 2160 0.331763519421924 706 17159339
SGTC_9 0092-0002 10.449 µM -0.436497865917937 0.362705912016285 no 2161 0.331237773625234 733 759368
SGTC_339 3091-4833 71.4 µM -0.437439273918619 0.362435164069217 no 2162 0.330896403500302 733 3240077
SGTC_1274 0865-0114 173 µM -0.43838722445309 0.362162604001143 no 2163 0.330552802963742 717 870624
SGTC_1215 3852-0577 11.2 µM -0.441213762399236 0.361350317184469 no 2164 0.329529125414749 718 2884876
SGTC_2845 9003024 42.97 µM -0.441744758060807 0.361197789922366 no 2165 0.329336958692624 720 2990173
SGTC_1669 st015249 58.4 µM -0.441892572180578 0.361155334586938 no 2166 0.329283472949402 743 722793
SGTC_1120 ficusin 1.78878 µM -0.442308452595881 0.361035894129084 no 2167 0.329133007605411 756 6199 A DNA cross-linker.
SGTC_561 1550-0330 72.9 µM -0.44252746593522 0.360972999152852 no 2168 0.329053779802978 741 6812934
SGTC_2141 5621638 7.665 µM -0.442561080707322 0.36096334619093 no 2169 0.329041620380692 755 2856238
SGTC_2752 diclazuril 33.15 µM -0.442602549738593 0.360951437888319 no 2170 0.329026620097965 723 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3250 9135583 49.47 µM -0.442804410112381 0.360893473317874 no 2171 0.328953606586003 724 7699353
SGTC_2645 abamectin 100 µM -0.442837198199954 0.360884058460974 no 2172 0.328941747650905 739 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_816 0325-0417 81.3 µM -0.443330653414691 0.360742376628748 no 2173 0.328763293469678 725 68101
SGTC_897 1000-0139 31.4 µM -0.443446735476047 0.360709049694881 no 2174 0.328721318979139 739 6151020
SGTC_3030 9087619 49.47 µM -0.444088156235217 0.360524918120946 no 2175 0.328489424524288 727 25236973
SGTC_1864 st057645 30.4 µM -0.446583712912068 0.359808830884429 no 2176 0.327587828717617 761 688666
SGTC_1938 st074717 56.4 µM -0.448428632584052 0.359279756648644 no 2177 0.326921940720861 732 17250979
SGTC_1883 5-benzylidenerhodanine 20 µM -0.451438112430569 0.358417296506409 no 2178 0.325836909890866 749 1273210
SGTC_523 1934-0222 13.7 µM -0.451940032049316 0.358273525917684 no 2179 0.325656092083658 762 1361595
SGTC_821 1114-0266 29.2 µM -0.452602887547485 0.358083687409855 no 2180 0.325417359571181 734 3123235
SGTC_2304 7443016 91.4 µM -0.452746766957123 0.358042485697215 no 2181 0.325365549749856 748 939854
SGTC_2207 7258803 200 µM -0.453711773436792 0.357766186479569 no 2182 0.325018145924101 767 3666799
SGTC_2888 9058547 12.99 µM -0.453987475280642 0.35768726161661 no 2183 0.324918920752368 723 16476514
SGTC_2830 7992007 71.43 µM -0.454037318985209 0.3576729935636 no 2184 0.324900983314329 747 1952075
SGTC_1354 1498-1681 81 µM -0.4555030946469 0.357253495676921 no 2185 0.324373670858307 753 5754243
SGTC_644 1498-1197 63.3 µM -0.45567056406503 0.35720557771047 no 2186 0.324313446159787 744 6741615
SGTC_918 glabranin 770.725 nM -0.459539437285196 0.356099206699309 no 2187 0.322923419241727 739 124049 Also referred to as licorice root.
SGTC_215 1287-0124 461.5 µM -0.45956391844383 0.356092209734346 no 2188 0.322914631380345 748 5560863
SGTC_2884 9058502 51.95 µM -0.460975080084152 0.355688967313041 no 2189 0.322408242000878 752 6471554
SGTC_2455 5377712 9.75 µM -0.462209848697868 0.355336261981861 no 2190 0.321965420618182 712 2243908
SGTC_2264 7948757 110.76 µM -0.462571203605497 0.355233066220221 no 2191 0.321835876751558 747 2971411
SGTC_1015 4130-4525 82 µM -0.465534607686254 0.354387178167858 no 2192 0.320774329765611 738 1363237
SGTC_2027 5150920 200 µM -0.4682609946765 0.353609579182958 no 2193 0.31979897915101 745 786715
SGTC_282 k297-0036 65.7 µM -0.468846733689575 0.353442598793617 no 2194 0.319589596296907 747 5061378
SGTC_2790 5423970 71.43 µM -0.469165239777977 0.35335181204916 no 2195 0.319475764744363 748 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2723 salbutamol 83.58 µM -0.470150959875301 0.353070895997055 no 2196 0.319123584005245 762 9884233 β2-adrenoceptor agonist
SGTC_1986 st071812 45 µM -0.472748744946042 0.352330948459822 no 2197 0.318196222714529 765 11838594
SGTC_1653 st012112 65 µM -0.472781944188121 0.352321495667957 no 2198 0.318184378553832 767 720429
SGTC_1138 3761-0006 1.03 µM -0.474314743659135 0.351885162404513 no 2199 0.317637739655054 759 12061087
SGTC_715 0868-0130 184 µM -0.475117996340224 0.351656582882822 no 2200 0.317351436003651 749 2876258
SGTC_1431 4049-0260 9.09 µM -0.476832653470187 0.351168826856767 no 2201 0.316740645801332 764 3854841
SGTC_2275 7947463 200 µM -0.477263814761988 0.351046216072012 no 2202 0.316587137261588 769 1225414
SGTC_51 1013-0126 23.419 µM -0.477288181805262 0.351039287196876 no 2203 0.316578462682441 768 1627850
SGTC_1348 1493-0373 93.8 µM -0.479732590890055 0.350344460832616 no 2204 0.315708775253944 775 3010129
SGTC_2770 toltrazuril 17.5 µM -0.481345751940264 0.349886191769113 no 2205 0.315135392570017 745 68591 Kills coccidiodes.
SGTC_1985 st071382 65.5 µM -0.482296451813025 0.34961621793323 no 2206 0.314797683740766 772 6123237
SGTC_2600 tangeritin 87.95 µM -0.485012242962081 0.348845423708172 no 2207 0.313833830486942 751 68077 A bioactive flavone.
SGTC_2788 5282734 71.43 µM -0.485340703790755 0.348752242346968 no 2208 0.313717343339328 782 743706
SGTC_2303 7774051 200 µM -0.485656767852169 0.348662586448871 no 2209 0.313605270179431 796 2953184
SGTC_2452 5863136 48.41 µM -0.486855374963902 0.348322661967026 no 2210 0.313180412449843 765 2184096
SGTC_658 3253-0951 102 µM -0.487684691242141 0.348087539482265 no 2211 0.312886598423856 754 1184878
SGTC_1743 st037606 46.3785 µM -0.489156467269359 0.34767041468642 no 2212 0.312365463385308 713 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_885 0865-0106 16.8 µM -0.48928137840112 0.347635021359449 no 2213 0.312321251377254 760 2793380
SGTC_2383 9036125 200 µM -0.490524204906521 0.347282941264791 no 2214 0.311881503063214 758 79580
SGTC_2932 9016711 44.54 µM -0.491777546565127 0.346928015751 no 2215 0.311438305598076 771 7117328
SGTC_1509 1326-1131 80 µM -0.493348028975666 0.346483470793759 no 2216 0.310883348695332 727 768313
SGTC_473 2-arachidonoylglycerol 10 µM -0.494041987378205 0.3462871043626 no 2217 0.310638263449775 741 5282280 An endocannabinoid.
SGTC_1179 1021-1431 9.29 µM -0.495540719748351 0.345863155511353 no 2218 0.310109242995218 776 2840958
SGTC_1205 4161-2785 76 µM -0.495615614785288 0.345841974894621 no 2219 0.310082816946105 770 3498106
SGTC_2092 5303694 80.6725 µM -0.499080869695322 0.344862515415573 no 2220 0.308861206959099 753 1963699
SGTC_1615 st002656 86.5 µM -0.499762557574409 0.344669957383999 no 2221 0.308621138932816 749 1584458
SGTC_757 1066-0008 322 µM -0.500730352653496 0.344396651077326 no 2222 0.308280453846751 749 6842497
SGTC_3090 9117696 49.47 µM -0.501641060583155 0.344139540415601 no 2223 0.307960015424895 767 7923821
SGTC_1874 staurosporine 7.6 µM -0.502332387147544 0.343944413491258 no 2224 0.307716865452003 783 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_898 1000-0849 28.3 µM -0.505393800591973 0.343080829600679 no 2225 0.306641136113446 768 6751807
SGTC_1655 st012546 55.1 µM -0.50698291415992 0.342632884446792 no 2226 0.306083403479298 761 720985 YLR208W SEC13
SGTC_14 0354-0009 295 µM -0.507701683927521 0.342430347605893 no 2227 0.30583128366172 775 1713507
SGTC_2448 5185112 27.17 µM -0.507984697490048 0.342350611725525 no 2228 0.305732037431938 737 5718189
SGTC_3089 9117425 49.47 µM -0.508296852048571 0.342262673847394 no 2229 0.305622588683891 792 9401657
SGTC_2433 5607874 27.82 µM -0.509063605472022 0.342046706045557 no 2230 0.305353820583103 758 2252428
SGTC_1201 1889-3372 45.9 µM -0.511451827253 0.341374358284512 no 2231 0.304517356012021 758 5392199
SGTC_2694 st077685 81.9 µM -0.515587127214092 0.340211352524097 no 2232 0.303071401474267 733 2838096
SGTC_3304 9125678 46.087 µM -0.517395247048497 0.339703315958772 no 2233 0.302440138450196 772 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1360 1598-0022 39.8 µM -0.518121861743145 0.339499237291354 no 2234 0.302186623997554 787 761525
SGTC_1145 3546-0597 10.2 µM -0.518995394684578 0.339253957120091 no 2235 0.301881976379215 753 875334
SGTC_2914 7968218 45.32 µM -0.519523073483182 0.339105822659172 no 2236 0.301698013472224 762 2977111
SGTC_2429 5902844 64.44 µM -0.524172523680205 0.337801666812955 no 2237 0.300079274839269 785 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1731 st035964 63 µM -0.524208309961022 0.337791636399222 no 2238 0.30006683084308 787 6739575
SGTC_1674 st016616 23.6 µM -0.531312790973713 0.33580263548164 no 2239 0.297601021558715 764 625830
SGTC_2048 5246248 200 µM -0.531685593401434 0.335698390410065 no 2240 0.29747188578479 761 677046
SGTC_2719 novobiocin 32.65 µM -0.532417494029187 0.335493769099311 no 2241 0.297218435730652 781 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_639 0833-0042 114 µM -0.532596274547581 0.33544379389991 no 2242 0.297156540781826 779 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3037 9091026 49.47 µM -0.53416567136763 0.335005219467055 no 2243 0.296613458741498 783 25236398 YIL048W NEO1
SGTC_1224 0823-0416 294 µM -0.536388340972872 0.334384470132807 no 2244 0.295845093756946 781 3598164
SGTC_505 gw-5074 63.9 µM -0.537911674172922 0.333959293408745 no 2245 0.295319014205175 769 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_468 gf-109203x 121 µM -0.543164607559007 0.332494786759118 no 2246 0.293508236231015 751 2396 A protein kinase C inhibitor.
SGTC_133 0724-0033 378.92 µM -0.54442210223339 0.332144577845875 no 2247 0.293075519860095 764 280309
SGTC_1166 k206-0078 225 µM -0.548255083878402 0.331078007867808 no 2248 0.291758381985131 760 5404595
SGTC_677 0929-0063 136 µM -0.54965554696747 0.330688654432673 no 2249 0.291277826027196 795 1539583
SGTC_1427 4048-4900 550 nM -0.550324527521465 0.330502730646369 no 2250 0.291048402002943 788 24132586
SGTC_2889 9059656 51.95 µM -0.550935059477786 0.330333087456968 no 2251 0.290839096377204 775 3949838
SGTC_2965 9082772 38.63 µM -0.554814668158272 0.329255910350426 no 2252 0.289510716560341 742 16459634
SGTC_980 1473-0395 201 µM -0.555441434278342 0.329082020738679 no 2253 0.289296379176052 790 768876
SGTC_34 0469-0683 81.75 µM -0.556500156890595 0.328788373378577 no 2254 0.288934493608764 764 3690923
SGTC_2377 9073351 62.6 µM -0.556843973184994 0.328693035193155 no 2255 0.288817018431232 807 7337946 YHR072W ERG7
SGTC_2318 6029776 164 µM -0.557012972807382 0.328646176703192 no 2256 0.288759282870676 807 818325
SGTC_2857 9024691 58.44 µM -0.559046236780012 0.328082625406378 no 2257 0.288065082611095 808 16478292
SGTC_2093 5331342 194.4 µM -0.559348677803596 0.327998832474755 no 2258 0.28796189004039 777 33839
SGTC_2793 7325131 81.82 µM -0.560730825475378 0.327616011168433 no 2259 0.287490524916926 763 4176441
SGTC_1666 st014829 29 µM -0.562891281993718 0.327017980209138 no 2260 0.286754458516169 775 3858230
SGTC_1091 telmisartan 47.6 µM -0.564348831886229 0.326614769869924 no 2261 0.286258377242596 809 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1758 st042942 75.2445 µM -0.565703441890537 0.326240217864322 no 2262 0.285797697537224 780 669317
SGTC_342 k048-0088 23.3 µM -0.56574122078581 0.326229774443868 no 2263 0.285784854636199 765 6820570
SGTC_521 r062-0005 13.8 µM -0.566640563658671 0.32598120456791 no 2264 0.285479204917525 774 2832033
SGTC_24 0417-1663 219 µM -0.567320134983629 0.325793428747596 no 2265 0.285248349806118 806 4329390
SGTC_2417 cerulenin 830 nM -0.567903337557889 0.325632316296264 no 2266 0.285050302779568 795 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2622 2-methoxyxanthone 59.94 µM -0.572684612209762 0.324312696950635 no 2267 0.283429129085066 778 71034 A hepatoprotective.
SGTC_1705 st027868 56.3335 µM -0.574339590757487 0.323856439699866 no 2268 0.282869011547306 790 292948
SGTC_50 0929-0078 56.389 µM -0.57631628234074 0.323311836815354 no 2269 0.282200709626158 763 1377751
SGTC_2022 5136654 200 µM -0.576401705467221 0.32328831021289 no 2270 0.2821718459626 804 1713771
SGTC_981 1488-1094 54.9 µM -0.577343862281338 0.323028875282693 no 2271 0.281853594425336 789 3449522
SGTC_235 0330-0087 5 mM -0.578414383484395 0.322734198039241 no 2272 0.281492192679401 769 46494818 YHR062C RPP1
SGTC_1926 methyl fluorone black 53.6 µM -0.579138276684693 0.322534998479608 no 2273 0.281247937303565 764 72721 Reacts with homocysteine.
SGTC_2328 6201408 200 µM -0.58030314533843 0.322214559067899 no 2274 0.28085510335732 826 2890418
SGTC_1676 st018489 23.4 µM -0.580852688718545 0.3220634330523 no 2275 0.280669870482735 792 3696235
SGTC_1384 3089-0840 101 µM -0.58521945994223 0.320863605704206 no 2276 0.279200080831765 776 1069836
SGTC_1749 st037932 54.2 µM -0.585821121529909 0.320698437518841 no 2277 0.278997864192973 810 594497
SGTC_2177 5811945 192 µM -0.586090827017384 0.320624409466189 no 2278 0.278907240124025 787 5343475
SGTC_3239 9133757 49.47 µM -0.589514661240681 0.319685265413651 no 2279 0.277758040001057 819 17036923
SGTC_3048 9093155 49.47 µM -0.592590477356132 0.318842565829747 no 2280 0.276727626777283 776 25236002
SGTC_1397 3532-0190 20.1 µM -0.593522026632412 0.318587528164761 no 2281 0.276415923197034 777 5322280
SGTC_3051 9093778 49.47 µM -0.596278391258839 0.317833399870999 no 2282 0.275494632093987 822 17217378
SGTC_605 1315-0399 119 µM -0.596536899142383 0.317762712015021 no 2283 0.275408305594262 797 24020461
SGTC_13 0199-0087 65 µM -0.597289932411929 0.317556836203415 no 2284 0.275156912444329 789 4589825
SGTC_2149 5554786 194.827 µM -0.597342780225232 0.317542389973503 no 2285 0.275139273937715 788 745063 YPR165W RHO1
SGTC_2675 theaflavin digallate 100 µM -0.597876495330605 0.317396511695548 no 2286 0.274961172189594 800 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3140 9094243 49.47 µM -0.598534603685313 0.317216672537021 no 2287 0.274741638411754 814 19291112
SGTC_2566 crystal violet carbinol 226 nM -0.598559058567433 0.317209990661166 no 2288 0.274733482343788 816 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2553 4-methylesculetin 85.09 µM -0.601057407098284 0.316527674220519 no 2289 0.273900875506154 797 5319502
SGTC_933 2914-0560 114 µM -0.601526246915396 0.316399700251453 no 2290 0.273744767721006 776 463887
SGTC_1089 terbinafine 2.25 µM -0.604204503663721 0.315669068254965 no 2291 0.272853843529827 807 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1080 nisoldipine 24.4 µM -0.606017400242386 0.31517491598141 no 2292 0.27225159938895 816 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1049 3226-0134 66 µM -0.609211753852959 0.314305016210507 no 2293 0.271192045228779 798 5702385
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.609677550897435 0.314178254366197 no 2294 0.271037714161672 803 676296 Flavone; oxidizing agent.
SGTC_1012 4112-3522 18 µM -0.61008794327538 0.314066588488381 no 2295 0.270901776460494 779 3112398
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.610484966424688 0.313958576513903 no 2296 0.270770299546954 813 1273210
SGTC_2437 5741531 144.16 µM -0.611565776548105 0.313664617916488 no 2297 0.270412543404778 820 2262990
SGTC_839 0122-0028 230 µM -0.611956371531918 0.31355841302765 no 2298 0.270283311715663 816 759448
SGTC_1908 st060353 56.5 µM -0.613132495843907 0.313238711813812 no 2299 0.269894367503641 833 4227716
SGTC_2618 avocadyne 43.43 µM -0.613856044907657 0.313042102033363 no 2300 0.26965522916637 806 3015189
SGTC_2310 7668677 200 µM -0.615941944891217 0.312475598650959 no 2301 0.26896641835084 827 2197143
SGTC_2371 9071574 200 µM -0.616239072757359 0.312394938581292 no 2302 0.268868372005466 804 45596039
SGTC_2957 9076800 11.52 µM -0.616564240491597 0.312306676945566 no 2303 0.26876109362769 811 16459615
SGTC_569 4130-2812 160 µM -0.618838050058165 0.311689788494862 no 2304 0.268011526476544 814 743552
SGTC_2291 7917025 104.35 µM -0.620731117821478 0.31117659867653 no 2305 0.267388275769443 808 2964612
SGTC_2446 5162541 200 µM -0.621204095824758 0.311048436788626 no 2306 0.267232672447709 809 1549321
SGTC_3251 9135047 49.47 µM -0.621408697574668 0.310993003366442 no 2307 0.26716537542122 780 17682963
SGTC_725 1497-0963 19 µM -0.624975967948188 0.310027201172779 no 2308 0.265993415489326 808 3549977
SGTC_1951 sophoraflavanone G 9.2 µM -0.629345624864292 0.308845945272991 no 2309 0.264561403918069 797 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1392 3455-1037 33.9 µM -0.630834399849281 0.308443932863409 no 2310 0.264074404171676 798 981132
SGTC_1478 0453-0656 35.7 µM -0.63141025359321 0.308288497200238 no 2311 0.263886156692737 827 5258496
SGTC_2155 5570423 76 µM -0.63315802958841 0.30781694432833 no 2312 0.263315225230495 824 797402
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.636117550011713 0.307019184441583 no 2313 0.262349903735055 827 61125 An anti-inflammatory.
SGTC_36 0335-0881 14.2 µM -0.63640264821131 0.306942382324908 no 2314 0.262257007632778 808 23828853
SGTC_1660 st012960 28.1 µM -0.63806050336604 0.306495943505357 no 2315 0.261717147912458 823 24207266
SGTC_2376 9072922 81.32 µM -0.638220999000734 0.306452739347641 no 2316 0.261664914812068 815 17087968
SGTC_292 k038-0015 474 µM -0.638963881188456 0.306252796380078 no 2317 0.261423214453775 822 46368540
SGTC_1701 st028638 40.4 µM -0.643099043602098 0.305140893982466 no 2318 0.26007991752778 813 3490878
SGTC_1181 1222-0449 220 µM -0.644501502579982 0.304764194629252 no 2319 0.259625141791256 822 658318
SGTC_399 oxolinic acid 75 µM -0.644744294234856 0.304699001983277 no 2320 0.259546453386249 801 4628 A DNA gyrase inhibitor.
SGTC_2955 9076254 12.21 µM -0.646514916880475 0.304223754923226 no 2321 0.258972969902149 801 16459619
SGTC_486 niguldipine 82 µM -0.647478576531111 0.303965241005055 no 2322 0.258661127723571 810 1236 A calcium channel blocker.
SGTC_662 k832-1615 104 µM -0.649559799073225 0.303407261159648 no 2323 0.257988303875246 813 5878478
SGTC_477 mead ethanolamide 10 µM -0.649995925594336 0.303290392806826 no 2324 0.257847426728019 778 16061185
SGTC_1011 4112-3381 17.4 µM -0.650642548704601 0.303117154954904 no 2325 0.257638628679978 826 2877139
SGTC_935 2996-0153 430 µM -0.65175396943479 0.302819495881335 no 2326 0.257279950244626 820 23738523
SGTC_2152 5568786 200 µM -0.656503787170785 0.301548884338093 no 2327 0.255750015811661 826 5399883
SGTC_1721 st082152 9.2685 µM -0.657218881884326 0.301357799107506 no 2328 0.255520093138512 830 5296051
SGTC_1385 3091-4834 14.1 µM -0.658377155090866 0.301048404916185 no 2329 0.255147905594247 807 4072814
SGTC_187 1488-2104 32.728 µM -0.661055182063466 0.300333607817248 no 2330 0.254288462869606 817 2852859
SGTC_2263 7948595 193.29 µM -0.662354193337974 0.299987162805168 no 2331 0.253872126474148 814 2971371
SGTC_3062 9077494 49.47 µM -0.663598127050007 0.299655576521159 no 2332 0.253473778184629 775 16459633
SGTC_879 0831-1030 162 µM -0.663848527097928 0.299588849298759 no 2333 0.253393631623838 826 1549252
SGTC_3337 9144342 33.5465 µM -0.664419837077355 0.299436630418931 no 2334 0.253210819992311 806 17682949
SGTC_932 2857-0803 154 µM -0.664959014739936 0.29929300499239 no 2335 0.253038353913019 824 674898
SGTC_2872 9044037 25.97 µM -0.665384846368033 0.299179594623575 no 2336 0.252902187380165 822 6465195
SGTC_2300 7976697 71.57 µM -0.667034564008271 0.298740414878578 no 2337 0.252375027888647 808 2236109
SGTC_2086 5274770 176.623 µM -0.667135041892482 0.298713675618823 no 2338 0.252342939377911 822 689278
SGTC_612 0302-0167 22.4 µM -0.672009443583543 0.297417804605269 no 2339 0.250788842185451 848 235821
SGTC_2900 5328528 85.29 µM -0.672169909728683 0.297375187994273 no 2340 0.250737767336358 819 795359
SGTC_2262 9014885 67.46 µM -0.672849255074614 0.297194798316217 no 2341 0.25052159920411 822 6457424
SGTC_549 1661-1316 519 µM -0.672875857324824 0.297187735516778 no 2342 0.250513136360311 836 2857282
SGTC_1548 st061468 90.8 µM -0.673269633539397 0.297083198356949 no 2343 0.250387883977083 824 390799
SGTC_2250 alverine citrate 130 µM -0.673952109882081 0.29690205879396 no 2344 0.250170880469654 816 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_118 0083-0097 135.343 µM -0.675033689786966 0.296615094655926 no 2345 0.249827180453685 860 5207356
SGTC_2121 5257820 149.641 µM -0.675496283152853 0.296492398459498 no 2346 0.249680256009467 801 791256
SGTC_2457 5731572 11.68 µM -0.678879645393407 0.295595718573695 no 2347 0.248607061847336 832 2865357
SGTC_175 3793-3120 23.7 µM -0.679616896472021 0.295400493217633 no 2348 0.248373534110227 854 5322297
SGTC_800 3448-7362 155 µM -0.679803920887792 0.295350978263819 no 2349 0.24831431184813 838 15991913
SGTC_3264 9137442 49.47 µM -0.683306755003539 0.294424304862056 no 2350 0.247206513315678 827 17015726
SGTC_2418 pentamidine 31.67 µM -0.683902495582446 0.29426683556792 no 2351 0.247018369034968 817 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1131 3454-3128 32.3 µM -0.688564630770509 0.293035861021947 no 2352 0.245548642615772 822 710982
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.690710690823326 0.292470026551158 no 2353 0.244873684781637 819 6708739 YPR165W RHO1
SGTC_924 2046-0044 21.3 µM -0.690920446118106 0.292414749307911 no 2354 0.244807768203209 823 3623589
SGTC_2683 piperine 63.03 µM -0.691278461374692 0.29232041203462 no 2355 0.244695282307965 837 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1394 3474-0001 65.7 µM -0.691573161203736 0.292242769043573 no 2356 0.244602710564558 809 5017666 YIL048W NEO1
SGTC_157 1348-1695 65.819 µM -0.693719173391047 0.291677660175681 no 2357 0.243929169737881 824 5380510
SGTC_1285 0929-0069 65.5 µM -0.693761138371859 0.291666614626684 no 2358 0.243916008720321 826 1206237
SGTC_127 0180-0333 59.125 µM -0.694040935241984 0.291592974634057 no 2359 0.243828268885186 798 771601
SGTC_938 3126-1755 342 µM -0.696718661013466 0.290888660421124 no 2360 0.242989439021556 821 1777771
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.69703230403317 0.290806215882493 no 2361 0.242891288797368 834 16486 A toxic proline analog.
SGTC_1319 1306-0155 43.7 µM -0.697394763481332 0.290710953014955 no 2362 0.242777888874734 841 3122360
SGTC_462 ag-879 158 µM -0.69814169841684 0.290514686987442 no 2363 0.242544291436814 856 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_823 0417-1665 178 µM -0.698853387261495 0.290327740000089 no 2364 0.242321830205026 852 3429856
SGTC_279 1273-0055 2.93 µM -0.698961840970984 0.290299256241511 no 2365 0.242287939222348 850 2847562
SGTC_1634 st006576 41 µM -0.699933528754421 0.290044115266024 no 2366 0.241984408613838 830 3915356
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.700899305300461 0.289790630639491 no 2367 0.241682929012377 835 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1422 4031-0024 15.5 µM -0.701159968058187 0.289722233041972 no 2368 0.241601594726722 856 782427
SGTC_2544 sphondin 68.51 µM -0.701736448304845 0.289570992221494 no 2369 0.241421769082138 822 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_906 1165-0455 526 µM -0.704864562005535 0.288750971936169 no 2370 0.240447262853254 841 3252859
SGTC_596 1155-0152 116 µM -0.705340202622899 0.288626380815631 no 2371 0.240299273646937 835 280313
SGTC_1151 3909-8316 15.3 µM -0.707941946999305 0.287945318452464 no 2372 0.239490654582249 842 800431
SGTC_2096 5468907 200 µM -0.708565892149695 0.287782100307139 no 2373 0.239296954282887 831 759785
SGTC_58 0957-0393 9 µM -0.709321664617637 0.287584455935898 no 2374 0.239062443591984 836 6997992
SGTC_271 rotenone 740 µM -0.710086122449084 0.287384605529523 no 2375 0.238825365755318 853 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1972 st070201 17.4 µM -0.711038744528042 0.287135655770052 no 2376 0.238530113460411 836 2829099
SGTC_2334 9017922 200 µM -0.711101443527853 0.287119274154298 no 2377 0.238510687766408 846 3163164
SGTC_3279 9140807 49.47 µM -0.711197413330079 0.287094200601414 no 2378 0.238480955635979 849 45595718
SGTC_1699 st031318 29.054 µM -0.711601383905651 0.286988668587566 no 2379 0.23835582491561 836 5340658
SGTC_3348 9149464 3.537 µM -0.711790256695101 0.286939334353489 no 2380 0.238297333516919 828 1951442
SGTC_1924 st058459 75.1 µM -0.715219553741919 0.286044289455741 no 2381 0.237236694153932 836 688683
SGTC_852 0418-0143 439 µM -0.716051695767946 0.285827300974427 no 2382 0.236979714372682 835 5369229
SGTC_163 TUB2.036 7.546 µM -0.71710938611982 0.285551611776299 no 2383 0.236653302334276 847 15992207 YJR013W GPI14
SGTC_931 2812-0076 566 µM -0.718177051105499 0.285273451098484 no 2384 0.236324063036368 847 3450959
SGTC_2998 9066762 71.4286 µM -0.718179122439632 0.285272911575568 no 2385 0.236323424537583 846 4945196
SGTC_415 dibenzyl ketone 100 µM -0.719078600048995 0.285038669505006 no 2386 0.236046245985425 849 7593
SGTC_1765 st044815 90.4 µM -0.719283091745591 0.284985428549421 no 2387 0.235983255839982 853 645695
SGTC_777 1315-0167 517 µM -0.719767902907793 0.284859223259838 no 2388 0.235833955131446 834 4221767
SGTC_591 4299-0174 154 µM -0.720689891853265 0.284619286126741 no 2389 0.23555016645868 851 5509088
SGTC_555 4296-0685 37 µM -0.72393598104123 0.283775297163357 no 2390 0.234552519473272 856 2908540 YHR072W ERG7
SGTC_573 3702-0553 84.7 µM -0.725515773116015 0.283364982380553 no 2391 0.234067835955098 842 1222756
SGTC_251 melphalan 456.522 µM -0.725853263845007 0.283277363788449 no 2392 0.233964365046727 852 460612 A DNA alkylator.
SGTC_3220 9131269 49.47 µM -0.726261585451507 0.283171373615127 no 2393 0.23383921205951 856 17722206
SGTC_2514 salinomycin 42.74 µM -0.726422520938557 0.283129603977695 no 2394 0.233789894575653 853 23682228 A polyether potassium ionophore.
SGTC_1240 0356-0016 42.1 µM -0.726572047313677 0.283090798142135 no 2395 0.233744078495987 811 4305613
SGTC_7 0192-1582 4.227 µM -0.727062240735663 0.282963598587453 no 2396 0.23359391421016 867 252616
SGTC_902 1120-0002 2.07 µM -0.727627322145202 0.282817000518337 no 2397 0.233420875374406 831 3280475
SGTC_406 estrone 100 µM -0.729348168145808 0.282370789338718 no 2398 0.232894357373273 844 5870 A steroid.
SGTC_362 0310-0100 9.03 µM -0.730357554917029 0.282109215483794 no 2399 0.232585827980429 830 790235
SGTC_23 0213-0011 39.996 µM -0.731404113790892 0.281838132046671 no 2400 0.23226617663806 862 627608
SGTC_3111 9122088 49.47 µM -0.731772564956514 0.281742724387703 no 2401 0.232153698497594 843 16876704
SGTC_3146 9095609 49.47 µM -0.734457907601982 0.281047845726661 no 2402 0.231334852551225 850 17173999
SGTC_2482 5981709 142.65 µM -0.734724129817158 0.280979001282656 no 2403 0.231253760832948 870 877755
SGTC_2341 7987486 176.74 µM -0.73501435593313 0.280903958771997 no 2404 0.231165375557139 825 1258686
SGTC_1745 st081495 74 µM -0.735463649849588 0.28078780589953 no 2405 0.231028585059211 832 13842402 YBL026W LSM2
SGTC_2282 7944268 200 µM -0.739318762309266 0.279792125859025 no 2406 0.229856729468004 853 2970414
SGTC_647 0140-0236 81 µM -0.739431297909582 0.279763086450584 no 2407 0.229822571585896 836 990837
SGTC_2650 prasterone 100 µM -0.740550749577712 0.279474295609511 no 2408 0.229482939698165 835 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_507 nimesulide 162 µM -0.741516594409119 0.279225247926507 no 2409 0.229190136943792 841 4495 A COX2 inhibitor.
SGTC_1114 scopoletin 1.73284 µM -0.741865139007896 0.27913540053773 no 2410 0.229084524628223 847 5280460 A coumarin with genotoxic properties.
SGTC_1862 st057513 3.81 µM -0.743321312729346 0.278760182004226 no 2411 0.228643585597555 863 5393163
SGTC_2630 antimycin a 100 µM -0.744340419663228 0.278497730462394 no 2412 0.228335276995385 869 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_91 0417-1751 58.384 µM -0.744673717061437 0.278411922208384 no 2413 0.22823449585322 857 6795624
SGTC_203 k066-0004 30.888 µM -0.74548785378647 0.278202374846683 no 2414 0.22798842559815 861 6795412
SGTC_290 2043-6722 48.1 µM -0.746406569035294 0.277966002840719 no 2415 0.22771092611921 850 773758 YLR208W SEC13
SGTC_693 4161-2696 114 µM -0.746660623835174 0.277900655556491 no 2416 0.227634222012334 868 805759
SGTC_1065 prochlorperazine maleate 2.48 µM -0.747249895018227 0.27774911369995 no 2417 0.227456365543356 868 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1230 0170-0365 3.77 µM -0.748394113827071 0.277454972226072 no 2418 0.227111235947132 842 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2996 9066192 71.4286 µM -0.748421851867359 0.277447843568033 no 2419 0.227102873016004 842 6472854
SGTC_2794 7785382 27.27 µM -0.749161843217182 0.277257699340897 no 2420 0.226879832076908 845 2205081
SGTC_2754 granisetron 64.02 µM -0.749386324034823 0.277200030551276 no 2421 0.226812195704048 853 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2430 5571206 200 µM -0.750070411488408 0.277024325694728 no 2422 0.226606149401927 850 1731771
SGTC_3318 9139014 38.6185 µM -0.750813476210978 0.27683353457384 no 2423 0.226382458979793 870 16643984
SGTC_2199 6590217 200 µM -0.751902913180048 0.27655392446732 no 2424 0.226054723055081 813 703109
SGTC_308 4092-1169 104 µM -0.752227308952661 0.276470693231151 no 2425 0.225957186738149 871 2268590 YDL196W YDL196W
SGTC_1813 st051246 8.6015 µM -0.753888060613563 0.276044781499451 no 2426 0.225458220185185 834 5291959
SGTC_3256 9138902 49.47 µM -0.754806281072231 0.275809435632099 no 2427 0.225182612303386 882 17228773
SGTC_162 k030-0015 37.8 µM -0.756288399528853 0.275429767180334 no 2428 0.2247381508782 874 1809920 YMR134W ERG29
SGTC_2043 5101342 149 µM -0.756687619958171 0.275327544429186 no 2429 0.224618516753035 858 678451
SGTC_3117 9124945 49.47 µM -0.756982642098105 0.275252014265278 no 2430 0.224530130878936 841 17592065
SGTC_585 0kpi-0023 191 µM -0.757067510450633 0.27523028856288 no 2431 0.224504708769499 829 64601
SGTC_338 4055-0136 114 µM -0.757910517698491 0.27501453047695 no 2432 0.224252276693492 858 2900563
SGTC_909 3448-9333 149 µM -0.759578144240865 0.274587966086431 no 2433 0.223753393693088 865 3344074
SGTC_2812 7970281 58.44 µM -0.761955872211946 0.273980328900845 no 2434 0.223043170821888 872 2233435
SGTC_739 1486-1183 203 µM -0.765180643931565 0.273157289858151 no 2435 0.222081991985351 858 4346692
SGTC_1358 1509-0022 2.48 µM -0.76672449072464 0.272763697275612 no 2436 0.221622669632928 872 3258434
SGTC_2528 xanthyletin 44.79 µM -0.767890983337382 0.272466495146244 no 2437 0.221275977340768 872 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_348 k064-0012 10.7 µM -0.768208913076825 0.272385520047812 no 2438 0.221181539531316 863 5066323
SGTC_3144 9087057 49.47 µM -0.769595246873541 0.272032567600336 no 2439 0.22077001270271 856 17249618
SGTC_1587 estradiol valerate 56.1 µM -0.769938678983814 0.271945166962129 no 2440 0.220668134263798 869 13791 A steroid.
SGTC_1067 clotrimazole 1.36 µM -0.77025980649667 0.271863455298111 no 2441 0.220572896806466 840 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2751 anetholtrithion 17.25 µM -0.772662442280108 0.27125248674275 no 2442 0.219861089745426 869 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2337 9009472 200 µM -0.775178143251483 0.270613501088295 no 2443 0.219117200759515 847 5742383
SGTC_257 daunorubicin 18.5 µM -0.776425470950633 0.270296960069859 no 2444 0.218748905143453 846 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_138 0850-0259 40.9225 µM -0.778259210692476 0.269831938496639 no 2445 0.218208108353331 857 6813004
SGTC_2572 astragaloside iv 100 µM -0.778663820568323 0.269729386670521 no 2446 0.218088886790822 865 45006101 An anti-inflammatory agent.
SGTC_3185 9108267 49.47 µM -0.78086532479822 0.26917173891355 no 2447 0.217440854102645 863 4910486
SGTC_2484 5809818 12.04 µM -0.781579581799825 0.268990939779952 no 2448 0.217230845175182 850 2870548
SGTC_2817 7995342 71.43 µM -0.782008842624561 0.268882310767389 no 2449 0.217104688437223 875 18879975
SGTC_1633 st005664 67.9 µM -0.783282007275054 0.268560252535112 no 2450 0.216730763363109 873 2063822
SGTC_697 0508-1955 564 µM -0.784410190540886 0.268275030742963 no 2451 0.21639973039183 851 6243113
SGTC_1498 4478-3555 97.6 µM -0.784930317510847 0.268143586120763 no 2452 0.216247212682897 856 3437919
SGTC_1350 1495-0454 146 µM -0.785890935536367 0.267900907419557 no 2453 0.215965692714756 854 1069057
SGTC_1663 st014140 55.4 µM -0.787210322394056 0.267567774179896 no 2454 0.215579377791924 866 4207120
SGTC_216 k038-0035 28.382 µM -0.789098410036241 0.267091412694554 no 2455 0.215027245584219 865 4444231 YPR107C YTH1
SGTC_1176 0848-0131 83.3 µM -0.790793288123441 0.266664162679886 no 2456 0.214532313627559 874 6769040
SGTC_3242 9133940 49.47 µM -0.791632321560698 0.266452784514886 no 2457 0.214287547502282 871 17248444
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.793580317298992 0.265962351912562 no 2458 0.21371989734103 858 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_139 0099-0334 718.624 µM -0.793857697244047 0.265892555211813 no 2459 0.213639139525554 895 97690
SGTC_1501 4491-0275 38.4 µM -0.794597702085263 0.265706394322549 no 2460 0.213423777733576 868 5104718
SGTC_884 0851-0618 334 µM -0.796439338827024 0.265243386114707 no 2461 0.212888360378626 872 9642473
SGTC_117 lucigenin 22.078 µM -0.79698625214984 0.26510596487972 no 2462 0.212729507869897 887 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2294 7971431 200 µM -0.800872626731008 0.264130490091719 no 2463 0.211602694239676 895 5741572
SGTC_1260 0700-1617 7.75 µM -0.802324046709881 0.263766655144496 no 2464 0.211182767972847 847 2853078
SGTC_2011 4012611 177 µM -0.802810273084183 0.263644827443685 no 2465 0.211042201745544 875 2049887
SGTC_3159 9100096 49.47 µM -0.803823605642322 0.263391021582556 no 2466 0.210749427406075 866 25236875
SGTC_744 1594-0068 283 µM -0.80462094408891 0.263191402740595 no 2467 0.210519226147618 875 668392
SGTC_1917 st066507 28.5 µM -0.804833002529741 0.263138325550594 no 2468 0.210458027161889 869 3156428
SGTC_527 4476-4215 268 µM -0.805013925995697 0.263093045616271 no 2469 0.210405821827737 851 4418754
SGTC_559 1550-0661 158 µM -0.805801864097235 0.262895893834603 no 2470 0.210178551528549 874 5830875
SGTC_2569 tetrandrine 100 µM -0.806541163658733 0.262710980724217 no 2471 0.209965441541542 864 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_771 0250-0039 27.3 µM -0.806584671074044 0.262700100752099 no 2472 0.209952904081234 879 3005115
SGTC_1027 k015-0025 8.67 µM -0.80829270858658 0.262273151195515 no 2473 0.209461049482138 883 3598955
SGTC_213 1246-0773 967 nM -0.809019854082262 0.26209149821787 no 2474 0.209251863116214 879 6251622
SGTC_2540 epiandrosterone 100 µM -0.809050571995814 0.262083825794534 no 2475 0.209243028846301 884 441302 A steroid.
SGTC_2164 5685496 200 µM -0.809367940215387 0.262004563369426 no 2476 0.209151768686097 896 759046
SGTC_798 1287-0182 476 µM -0.809533823974145 0.26196313894191 no 2477 0.209104077652956 903 1649755
SGTC_1727 st034309 9.9045 µM -0.809801494695869 0.261896303395265 no 2478 0.209027136707821 904 870305
SGTC_2072 5231554 129 µM -0.812272612832818 0.261279695386396 no 2479 0.208317610919831 869 789545
SGTC_572 0960-0087 17.7 µM -0.812494199389679 0.261224440258864 no 2480 0.208254056829733 886 6796365
SGTC_2007 4011539 71.82 µM -0.813163866849867 0.261057487563282 no 2481 0.208062056478184 879 45595301
SGTC_950 1165-0508 94.1 µM -0.815143690594918 0.260564224919481 no 2482 0.207495032650997 882 6148369
SGTC_3299 9121982 43.1275 µM -0.815542699361114 0.260464872117907 no 2483 0.2073808667584 875 17594604 YPL160W CDC60
SGTC_424 splitomicin 100 mM -0.815603186798972 0.260449812506749 no 2484 0.207363563106724 896 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_206 4546-0025 72.014 µM -0.816118477565277 0.26032153829093 no 2485 0.207216188402712 877 6620745 YIL048W NEO1
SGTC_511 blebbistatin 171 µM -0.81613161735426 0.260318267755303 no 2486 0.207212431193789 888 3476986 A myosin inhibitor.
SGTC_1381 2324-0066 62.1 µM -0.816345373389219 0.260265066166023 no 2487 0.207151315165128 865 10885928
SGTC_11 0438-0307 1.3 µM -0.816843792191248 0.26014103682665 no 2488 0.207008851241724 891 4011476
SGTC_2560 caryophyllene 100 µM -0.817560469553847 0.259962748215299 no 2489 0.206804103733004 888 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2899 9053889 58.44 µM -0.818319442900185 0.259774006316419 no 2490 0.206587403446033 850 6470052
SGTC_1530 rhein 70.4 µM -0.819064057705665 0.259588903849606 no 2491 0.206374933528623 869 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1870 st057514 26.5 µM -0.820180744549825 0.259311436353863 no 2492 0.206056538635418 881 5393161
SGTC_1506 4226-2149 212 µM -0.822351207541155 0.258772571764069 no 2493 0.205438520201703 888 991114
SGTC_3068 9116768 49.47 µM -0.823476807568395 0.258493345482095 no 2494 0.205118450353426 877 41904888
SGTC_738 1315-0003 72.4 µM -0.825792227041691 0.257919453159258 no 2495 0.204460982086389 888 6251474
SGTC_156 3474-0145 5.642 µM -0.827231038114365 0.257563167441331 no 2496 0.20405306125795 850 2265471
SGTC_2492 derrusnin 100 µM -0.828540963253536 0.257239019544802 no 2497 0.203682103165404 884 1715307 Part of coumarin class of compounds.
SGTC_2581 avocatin a 64 µM -0.82891018040486 0.257147693135765 no 2498 0.203577617134675 890 6710728 A skin care supplement.
SGTC_3233 9132340 49.47 µM -0.830451658718225 0.256766588399914 no 2499 0.203141734334402 911 17682950
SGTC_3173 9105693 49.47 µM -0.830545800533002 0.256743322940582 no 2500 0.203115131980354 897 17096658
SGTC_2004 4023728 41.89 µM -0.830924633809581 0.256649712192413 no 2501 0.203008103264681 897 360084 YDR527W RBA50
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.832143116537321 0.256348742307612 no 2502 0.202664083588866 883 140250 A respiratory chain inhibitor.
SGTC_2746 daunorubicin 9.88 µM -0.832720981367895 0.256206071819809 no 2503 0.202501054297117 842 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3197 9113331 49.47 µM -0.832897986941634 0.256162378756972 no 2504 0.202451132542597 875 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1816 st051957 91.6 µM -0.833035842170751 0.256128352479617 no 2505 0.202412257650443 908 674121
SGTC_2490 carminic acid 95.39 µM -0.834045878282505 0.255879121060575 no 2506 0.202127565724389 872 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1175 0741-0056 27.6 µM -0.834432372209049 0.255783785260456 no 2507 0.202018690754373 886 765927
SGTC_1034 k072-0165 12.7 µM -0.83450995190992 0.255764651042249 no 2508 0.201996840857258 899 5835461
SGTC_2805 7950783 58.44 µM -0.836175174771914 0.255354121546634 no 2509 0.201528181082933 877 1178958 YDL195W SEC31
SGTC_2807 7945238 51.95 µM -0.838201244813059 0.254855096775485 no 2510 0.200958844028422 894 17148797
SGTC_2598 perillyl alcohol 100 µM -0.841239211429506 0.2541077976283 no 2511 0.200106968845586 903 10819 An apoptosis inducer.
SGTC_972 1319-0219 195 µM -0.843298814634679 0.25360181732277 no 2512 0.19953067280117 884 23903702
SGTC_59 0330-0160 1.33 µM -0.843397458332617 0.253577596928613 no 2513 0.199503096471767 895 4293482
SGTC_1627 st003713 25.6 µM -0.843439054003408 0.253567384136188 no 2514 0.199491468885705 899 16195070 YER133W GLC7
SGTC_2843 9000894 45.46 µM -0.844142324778699 0.253394746035447 no 2515 0.199294939476383 822 2242070
SGTC_2202 7226349 200 µM -0.847139719849201 0.252659642259589 no 2516 0.198458624028887 875 844334
SGTC_2182 6325192 200 µM -0.847465416670397 0.252579833622346 no 2517 0.198367877738341 859 736248
SGTC_1487 3970-0795 2.82 µM -0.851329625469656 0.251633963634977 no 2518 0.197293136234554 876 3765103
SGTC_1956 st077085 54 µM -0.855915263682248 0.250513936438238 no 2519 0.19602232573961 899 24208685
SGTC_1214 0358-0031 63.7 µM -0.857131713219734 0.250217266529707 no 2520 0.195686048180788 927 4301366
SGTC_1377 2944-0135 198 µM -0.857812342768156 0.250051354690762 no 2521 0.195498046576044 882 1894137
SGTC_855 0428-0020 25 µM -0.85823642260665 0.249948009525333 no 2522 0.195380963904459 877 6812414
SGTC_2025 5147754 141 µM -0.858823268621483 0.24980503682512 no 2523 0.195219013980698 853 315777 YLR208W SEC13
SGTC_751 0833-0568 350 µM -0.85892460414901 0.249780352950075 no 2524 0.195191057017108 888 6954252
SGTC_1211 1056-0033 32.3 µM -0.861237508711219 0.249217314989106 no 2525 0.194553622791065 878 6741922
SGTC_1834 st055981 52.8 µM -0.863135177204601 0.248755863848115 no 2526 0.194031574504716 870 471719 YDL150W RPC53
SGTC_75 0159-0059 199.013 µM -0.863285622202511 0.248719300000799 no 2527 0.193990223656907 892 5377270
SGTC_1922 5578187 25 µM -0.864473819907709 0.248430623430205 no 2528 0.193663828015249 841 1350412
SGTC_659 k018-0002 107 µM -0.864791120908911 0.248353564320943 no 2529 0.193576722721028 908 6797879 YHR007C ERG11
SGTC_3164 9100705 49.47 µM -0.866506042126322 0.247937302483825 no 2530 0.19310635718723 855 17174235
SGTC_1149 3909-7961 23.3 µM -0.86920979452739 0.247281779245398 no 2531 0.192366195562808 894 735261
SGTC_2205 7238770 200 µM -0.87051464804578 0.24696575006892 no 2532 0.192009608874757 882 279867
SGTC_1389 3405-0187 19 µM -0.870838360771116 0.246887381893606 no 2533 0.191921208239979 870 799890
SGTC_3149 9097855 49.47 µM -0.873928719899969 0.24613990200977 no 2534 0.191078536542192 859 25236625 YMR079W SEC14
SGTC_1021 4476-0760 85.3 µM -0.876648282244911 0.245483113877464 no 2535 0.190338852845131 913 746768
SGTC_1408 3909-7976 48.8 µM -0.877410046752701 0.24529931283494 no 2536 0.190131979065603 898 24152374
SGTC_1850 st056238 17 µM -0.881237673861378 0.244376891168063 no 2537 0.189094596102596 882 5393177
SGTC_2297 7971671 152.32 µM -0.884813030515257 0.243516955668292 no 2538 0.18812874017806 897 909016
SGTC_2336 9001819 198.65 µM -0.887244659145653 0.242933041830154 no 2539 0.187473596618179 883 2989602
SGTC_77 0828-0286 12.516 µM -0.888293386290572 0.242681442017328 no 2540 0.187191478172444 911 745345
SGTC_684 1140-0066 328 µM -0.889006259030934 0.242510497504462 no 2541 0.186999858003017 885 6813534
SGTC_2815 7968870 71.43 µM -0.889705096168512 0.242342982008515 no 2542 0.186812128441703 921 2977326 YHR190W ERG9
SGTC_1113 artemisinin 1.17947 µM -0.889747296456882 0.242332868351579 no 2543 0.186800795857104 889 2240 An anti-malaria and mitochondrial poison.
SGTC_1007 4101-0031 70 µM -0.892383623943177 0.241701503794575 no 2544 0.1860936728015 932 1146276
SGTC_743 1275-0778 158 µM -0.895283797767321 0.241007984304587 no 2545 0.185317699589833 901 2849257 YMR203W TOM40
SGTC_805 3852-0218 479 µM -0.895362177377637 0.240989256393584 no 2546 0.185296756187722 889 6615355
SGTC_626 0214-0009 33 µM -0.895922143247634 0.240855481984489 no 2547 0.185147173421481 913 3437874
SGTC_2074 5212007 75.395 µM -0.895991731611268 0.240838860325726 no 2548 0.185128589636708 869 758611
SGTC_1984 st072354 53.1 µM -0.896113484902245 0.240809780216889 no 2549 0.185096077836053 893 5762938
SGTC_2520 obtusaquinone 4.71 µM -0.89816068194088 0.240321104628575 no 2550 0.184549945785249 894 5967872
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.898903519887078 0.240143919387691 no 2551 0.184352026478154 901 6728940
SGTC_2315 7733312 200 µM -0.900039671879044 0.239873056804983 no 2552 0.184049569433362 901 726316
SGTC_1673 st016611 27.3 µM -0.900828352808532 0.239685130565388 no 2553 0.183839795048154 920 5226799
SGTC_1712 st032288 53.4 µM -0.901649493862809 0.239489555161535 no 2554 0.183621545185451 901 2883011
SGTC_566 0958-0068 16.5 µM -0.903984857050642 0.238933806272254 no 2555 0.183001715526007 881 6815365
SGTC_2862 9027634 71.43 µM -0.907281014550566 0.238150617683695 no 2556 0.182129105672069 890 5012562
SGTC_696 1560-0013 611 µM -0.909112183547211 0.237716128512961 no 2557 0.181645456037562 896 1650269
SGTC_456 gingerol 170 µM -0.909341918864004 0.237661648965295 no 2558 0.181584834974935 908 442793 A herb.
SGTC_2753 fluvastatin 17.09 µM -0.910386416846195 0.237414042588191 no 2559 0.181309379305501 926 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2516 gossypol 71.55 µM -0.916859170665053 0.235882788700635 no 2560 0.179608220752948 922 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1412 3909-8563 178 µM -0.917257231474224 0.235788797814863 no 2561 0.179503931494028 922 23767530
SGTC_3038 9091290 49.47 µM -0.917759830026379 0.235670152777564 no 2562 0.179372308430603 897 25236843
SGTC_430 0958-0115 16.4 µM -0.917851883995381 0.235648425788553 no 2563 0.17934820744597 909 6833180
SGTC_2170 morpholine 200 µM -0.917898057667652 0.235637528088227 no 2564 0.179336119315635 908 121171 Reacts with secondary amines.
SGTC_979 1426-2828 121 µM -0.919506893641555 0.23525799156443 no 2565 0.178915250775167 916 747872
SGTC_2621 lithochol-11-enic acid 100 µM -0.920502466780384 0.235023297522202 no 2566 0.178655122273814 926 6708711
SGTC_2706 st078239 82.5 µM -0.922839287666381 0.23447292939195 no 2567 0.178045481725464 918 15434492
SGTC_2409 alverine citrate 63.97 µM -0.925101924275372 0.233940713301152 no 2568 0.177456446110498 896 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2861 9024595 19.48 µM -0.925109549328266 0.233938920872813 no 2569 0.177454463151022 874 16482810
SGTC_996 3970-0799 1.8 µM -0.926098428728743 0.233706528552442 no 2570 0.177197415245066 918 6615648 YGL040C HEM2
SGTC_357 1325-0123 420 µM -0.928158874219122 0.233222723446733 no 2571 0.176662581912937 936 1098503
SGTC_558 k064-0027 21.3 µM -0.929356318725794 0.232941811818141 no 2572 0.176352228680174 879 5088526
SGTC_858 0438-0351 2.77 µM -0.932094201751686 0.232300231356786 no 2573 0.175643922149824 915 2799119
SGTC_754 3474-0146 171 µM -0.932224146747237 0.232269805218254 no 2574 0.175610349479479 891 24762078
SGTC_2983 9022671 12.99 µM -0.933151163775777 0.232052811966014 no 2575 0.175370962772325 898 6405161
SGTC_1088 bifonazole 369 nM -0.937093537873493 0.231131255033974 no 2576 0.174355222595785 900 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1604 st002052 72.4 µM -0.937896644313347 0.230943774115191 no 2577 0.174148763935809 906 6254834 YHR062C RPP1
SGTC_665 3914-0008 307 µM -0.940542523674865 0.23032670870044 no 2578 0.173469674069484 919 1069549
SGTC_588 3970-1144 52.9 µM -0.942359672979926 0.229903452231113 no 2579 0.173004263201694 894 1888707
SGTC_1299 1079-1439 3.74 µM -0.945255999953175 0.229229731019398 no 2580 0.172264097957089 927 323161
SGTC_801 0866-0028 10.1 µM -0.947735092207033 0.228653944140237 no 2581 0.171632165651983 910 6849771
SGTC_306 1672-3436 11.6 µM -0.949883109688889 0.228155709149407 no 2582 0.171085824999492 914 6797378
SGTC_1426 4048-4480 71.7 µM -0.952065054231905 0.227650230299713 no 2583 0.170531995240134 911 14224343
SGTC_1332 1480-0653 17.5 µM -0.952494610323004 0.22755079178059 no 2584 0.170423099016086 921 5749438
SGTC_2076 5212012 200 µM -0.954597712546133 0.227064294994902 no 2585 0.169890587197514 909 604802
SGTC_986 1493-0483 84 µM -0.954854058477562 0.227005036301217 no 2586 0.169825752654323 919 40079
SGTC_2468 5987765 72.9 µM -0.955896835890344 0.226764070592748 no 2587 0.169562178865579 908 26772094
SGTC_746 1095-0025 46.6 µM -0.95806091770197 0.226264453945579 no 2588 0.169016020702348 924 6749286
SGTC_1756 st041558 35.5 µM -0.960629835804844 0.22567218174558 no 2589 0.168369160767826 955 3955792
SGTC_905 2-aminofluorene 215 µM -0.960966772301618 0.22559456508993 no 2590 0.168284437586503 916 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2840 9008771 71.43 µM -0.963651431221704 0.224976667323141 no 2591 0.167610356096828 882 2992978
SGTC_1052 3253-3998 198 µM -0.966430373777129 0.224338080874127 no 2592 0.166914435734727 926 5450317
SGTC_2279 7948423 32.93 µM -0.966504830974858 0.224320985165523 no 2593 0.166895815365771 911 1247112
SGTC_2403 6032726 181.2 µM -0.966871607054862 0.224236782517721 no 2594 0.166804111004746 925 2881040
SGTC_2358 9037157 4 µM -0.967274749542031 0.224144251756356 no 2595 0.166703351527244 915 2388925
SGTC_431 k089-0097 107 µM -0.969399690303348 0.223656885998342 no 2596 0.166172903399536 895 5499420
SGTC_1988 st071872 53.4 µM -0.970223648953246 0.223468069219312 no 2597 0.165967512606009 919 16414116
SGTC_2104 5389443 200 µM -0.970462786281238 0.223413285952656 no 2598 0.165907932813323 936 2244536
SGTC_3261 9137475 49.47 µM -0.970684696186865 0.223362456101532 no 2599 0.165852657508462 866 17027690
SGTC_1310 1188-0297 994 nM -0.971637330023643 0.223144324142412 no 2600 0.165615502204823 900 1588352
SGTC_2905 7799065 20.05 µM -0.972317944002809 0.222988552988261 no 2601 0.165446199798292 903 1296806
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.973380672434017 0.222745451737345 no 2602 0.165182070579692 892 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3259 9138485 49.47 µM -0.973805163436104 0.222648390803175 no 2603 0.165076644431515 915 17646153
SGTC_940 3232-1287 54.8 µM -0.974092945744292 0.222582602370449 no 2604 0.1650051958961 932 1585493 YIL048W NEO1
SGTC_1798 st045719 60.953 µM -0.976234700191749 0.222093335206999 no 2605 0.164474085541369 887 3980186
SGTC_2944 9067346 25.62 µM -0.977903191828914 0.221712607035727 no 2606 0.164061103179422 928 6473075
SGTC_2513 baicalein 25.65 µM -0.980071851088761 0.221218304879332 no 2607 0.163525326421424 947 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2346 9031566 143.75 µM -0.980240165659746 0.221179967346612 no 2608 0.163483791139152 926 4771086
SGTC_2678 equilin 100 µM -0.980456107382517 0.221130787196486 no 2609 0.163430512856051 870 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.981878583307981 0.220806978505689 no 2610 0.163079833943544 910 3256 An antibiotic and ribosome inhibitor.
SGTC_522 1273-0010 11.6 µM -0.985638133220258 0.219952472747435 no 2611 0.162155359211353 886 5705015
SGTC_2555 cholic acid 100 µM -0.988918056860366 0.21920853325708 no 2612 0.161351617584705 917 6708657 Influences liver metabolism.
SGTC_2470 5664817 21.68 µM -0.989163466963356 0.219152928516683 no 2613 0.16129158476827 937 2859561
SGTC_352 k048-0007 5.11 µM -0.989699922648597 0.219031407243181 no 2614 0.161160406413223 949 6811911
SGTC_695 3505-6186 243 µM -0.991149313383805 0.218703276112037 no 2615 0.160806338206958 929 1819379
SGTC_1803 st050068 52.4 µM -0.992573939869727 0.218381027313159 no 2616 0.160458814923527 936 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1685 st024049 53.0905 µM -0.998315020911537 0.217085176844562 no 2617 0.159063313038269 933 1941139
SGTC_930 2810-3379 265 µM -0.999324633123409 0.216857752060028 no 2618 0.158818728127792 958 1015764
SGTC_2244 6635614 200 µM -1.00130729471665 0.216411539690988 no 2619 0.158339133647992 942 836499
SGTC_2411 st077133 39.94 µM -1.00144691001641 0.216380138294551 no 2620 0.15830539735512 959 1403142 YNL221C POP1
SGTC_3057 9095946 49.47 µM -1.00489668391416 0.215605074844153 no 2621 0.157473300693564 954 24540043
SGTC_847 0342-0274 5.54 µM -1.00514653306952 0.215549003623362 no 2622 0.157413148097143 938 18097
SGTC_3332 9141069 11.198 µM -1.00725212508609 0.215076802102803 no 2623 0.156906814936042 933 17332883
SGTC_2044 5102272 200 µM -1.00752934449266 0.21501467746067 no 2624 0.156840231709325 930 592666
SGTC_2055 5235184 200 µM -1.0081841217318 0.214867983796032 no 2625 0.156683039557384 917 2836034
SGTC_260 nsc-65238 3.989 µM -1.00837776303893 0.214824612316123 no 2626 0.156636572029071 938 3246252
SGTC_2129 girgensonine 121.053 µM -1.01124605949654 0.214182771582521 no 2627 0.15594933793035 935 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3203 9113543 49.47 µM -1.01157167585729 0.214109978766746 no 2628 0.155871447165154 932 17018012
SGTC_1927 st060202 13.8 µM -1.01334209248198 0.213714447200815 no 2629 0.155448394287304 909 688887
SGTC_2733 amorolfine 100 µM -1.01450288753531 0.21345534332194 no 2630 0.155171426142014 977 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2386 9075165 157.42 µM -1.01536787293789 0.213262386937479 no 2631 0.154965250757878 930 16452277
SGTC_1416 3966-0321 25.3 µM -1.01600530875116 0.213120256232944 no 2632 0.154813429266965 928 582530 YLR208W SEC13
SGTC_624 k048-0052 28 µM -1.0182522060678 0.212619700598255 no 2633 0.154279057605217 936 6835531
SGTC_1213 1315-0166 115 µM -1.01998159590113 0.212234901422158 no 2634 0.153868594613588 922 768401
SGTC_636 0kpi-0074 126 µM -1.02009448711836 0.21220979663928 no 2635 0.153841825537621 946 616434
SGTC_2586 curcumin 80 µM -1.02035081350244 0.212152801146672 no 2636 0.153781056165803 957 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_476 mead acid 10 µM -1.02056004483763 0.212106284115816 no 2637 0.153731463778897 949 5312531 An omega 9 fatty acid.
SGTC_3244 9134489 49.47 µM -1.0217923973484 0.211832424292779 no 2638 0.153439584215146 941 16584271
SGTC_309 k408-0051 1.48 µM -1.02450266202507 0.211230863416683 no 2639 0.152798957062116 913 3640463
SGTC_2685 mycophenolic acid 18.85 µM -1.02784513362408 0.2104903601903 no 2640 0.152011340898476 916 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2064 5220758 200 µM -1.02805874057363 0.210443088789422 no 2641 0.151961098637919 937 788518
SGTC_3106 9121286 49.47 µM -1.03197709930258 0.209577058810069 no 2642 0.15104142285175 910 15943471
SGTC_346 4513-0042 7.16 µM -1.03267414653605 0.209423218357667 no 2643 0.15087820814595 917 2827372
SGTC_1750 st081859 2.357 µM -1.03353361174594 0.209233623264622 no 2644 0.150677124694514 927 5291695
SGTC_875 0709-0210 25.7 µM -1.03456704704013 0.209005784804687 no 2645 0.150435575007138 950 6251364
SGTC_1288 0973-0013 65.5 µM -1.03486408070893 0.20894032570472 no 2646 0.150366195689016 941 4315430
SGTC_1649 st011737 51.3 µM -1.03591355741027 0.208709142931099 no 2647 0.150121236062797 878 1761035
SGTC_493 zm226600 134 µM -1.03717430567207 0.208431619876299 no 2648 0.149827315218804 936 5240098 A potassium channel opener. YCR052W RSC6
SGTC_200 k038-0079 37.545 µM -1.03864327776461 0.20810853608814 no 2649 0.149485335196109 967 3436683
SGTC_2891 9063876 19.48 µM -1.03867615172475 0.208101309215577 no 2650 0.149477688028556 926 6472478
SGTC_2662 daunorubicin 22.37 µM -1.03947588520914 0.207925544820215 no 2651 0.149291733809282 899 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1741 st038134 10.228 µM -1.04556354435971 0.206590482660553 no 2652 0.147881294031438 958 1272587
SGTC_792 4534-1957 155 µM -1.04597311406308 0.206500844088489 no 2653 0.147786722842512 933 1717904
SGTC_3305 9127027 53.8275 µM -1.04622886085737 0.206444882940827 no 2654 0.147727690486576 940 41905295
SGTC_1968 st069590 43.6 µM -1.04686708893881 0.206305268476346 no 2655 0.147580441365969 933 6384066
SGTC_2963 9082507 9 µM -1.05077042671853 0.205452619073631 no 2656 0.146682020666117 954 16459611
SGTC_356 1634-0012 32.5 µM -1.05100577968582 0.205401275292136 no 2657 0.146627967671881 947 735457
SGTC_1872 amphotericin b 148 nM -1.05117505191816 0.205364352164852 no 2658 0.146589099558893 931 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3072 9116419 49.47 µM -1.05342855803793 0.204873173564897 no 2659 0.146072310643896 942 17170162
SGTC_3277 9138724 49.47 µM -1.05447921974098 0.204644408254966 no 2660 0.145831784807893 939 15943418
SGTC_2187 6125751 200 µM -1.056325519377 0.204242773479811 no 2661 0.145409760412904 954 874498
SGTC_1876 myriocin 605 nM -1.05668821592389 0.204163929486785 no 2662 0.145326952418094 937 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2646 retinol 96.75 µM -1.057557605479 0.203975012964329 no 2663 0.14512858948447 912 445354 A vitamin A analog and teratogen.
SGTC_513 4245-1575 41.7 µM -1.05790349731007 0.203899880369644 no 2664 0.145049720298442 915 719745
SGTC_2306 7482397 179.52 µM -1.05843806087526 0.203783798053207 no 2665 0.144927887522274 984 891448
SGTC_2431 5490079 200 µM -1.05877767274221 0.203710070636791 no 2666 0.144850522129619 966 5722345
SGTC_2997 9067075 71.4286 µM -1.05995190425019 0.203455275578344 no 2667 0.14458324026532 931 27209819
SGTC_3296 9122258 64.045 µM -1.06037939913982 0.203362561211964 no 2668 0.144486015234461 951 4730474
SGTC_3328 9140624 29.0385 µM -1.06167645167396 0.203081412979045 no 2669 0.144191296625198 946 4904392
SGTC_843 0310-0051 143 µM -1.06579948448615 0.202189249771037 no 2670 0.143257147004747 942 2065037
SGTC_3135 9127742 49.47 µM -1.06632460934455 0.202075789117765 no 2671 0.143138464323873 939 3643468
SGTC_3034 9090421 49.47 µM -1.07356155920992 0.200516027822522 no 2672 0.141509617150086 932 17173761
SGTC_1220 1838-0075 193 µM -1.0745591108368 0.20030159650019 no 2673 0.141286083363009 920 5529645
SGTC_1708 st033234 31.827 µM -1.07504723449069 0.200196720824439 no 2674 0.141176790696134 941 674664
SGTC_3195 9113082 49.47 µM -1.07561447762267 0.200074887421094 no 2675 0.141049854919859 937 17018038
SGTC_416 estradiol valerate 100 µM -1.07650166204055 0.199884425900932 no 2676 0.140851478991278 954 13791 A steroid.
SGTC_3258 9138477 49.47 µM -1.07684124409825 0.199811552995558 no 2677 0.140775597987154 970 4970355
SGTC_848 0368-0089 85.6 µM -1.07977935363186 0.19918171435838 no 2678 0.140120223628206 933 762535
SGTC_531 3788-1495 174 µM -1.08150352142023 0.198812664236414 no 2679 0.139736597558688 927 2896655
SGTC_1795 st049545 62.3 µM -1.08332140877369 0.198424000645228 no 2680 0.139332892955959 896 5291882
SGTC_3165 9101544 49.47 µM -1.08725605086644 0.197584347190115 no 2681 0.138461832860971 958 5002184
SGTC_2924 9010168 62.78 µM -1.08739119747982 0.19755554508015 no 2682 0.138431979860612 964 2993929
SGTC_2698 st077697 67.5 µM -1.08907928394941 0.197195998186545 no 2683 0.138059462210701 952 3154499
SGTC_2462 5162487 171.77 µM -1.08907967799254 0.197195914305228 no 2684 0.138059375335313 967 2259986
SGTC_386 1509-0011 3.07 µM -1.09421077611385 0.196105470939624 no 2685 0.136931273169826 948 3107280
SGTC_831 k061-1017 217 µM -1.09421876651185 0.196103775704637 no 2686 0.136929521360673 981 1240153
SGTC_192 3455-0609 60.9 µM -1.09454656479403 0.196034238004828 no 2687 0.136857668301842 951 3769639
SGTC_753 1322-0200 289 µM -1.09511118996182 0.195914495956729 no 2688 0.136733963459411 960 5403907
SGTC_86 0417-1630 471.922 µM -1.09640924235209 0.195639381751654 no 2689 0.136449860554439 938 3634867
SGTC_716 1683-5115 658 µM -1.09808864659893 0.195283790606316 no 2690 0.136082891229159 946 723597
SGTC_994 3910-0338 138 µM -1.09957121459725 0.194970203461572 no 2691 0.135759494809949 957 3479481
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.10002868213658 0.194873503514264 no 2692 0.135659812579057 969 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2988 9073640 71.4286 µM -1.10096668167614 0.194675319466867 no 2693 0.135455579199228 970 9102229
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.10114141446895 0.194638414823378 no 2694 0.13541755741109 980 91467 include heat shock
SGTC_2115 tiliquinol 12.7705 µM -1.10140730742839 0.194582264758553 no 2695 0.135359713240663 952 71208 A bioactive hydroxyquinoline.
SGTC_1245 0418-0076 17.2 µM -1.10186386494023 0.194485874018752 no 2696 0.135260430111131 987 6790114
SGTC_1997 st073024 93.8 µM -1.1039766852572 0.194040183246859 no 2697 0.13480162573771 946 686268
SGTC_1373 2887-0003 58.5 µM -1.10659915614506 0.193487850133371 no 2698 0.1342336361564 973 776948
SGTC_815 1582-0027 36.9 µM -1.10674608292738 0.193456933467993 no 2699 0.13420186262152 956 3128206
SGTC_3253 9135987 49.47 µM -1.10702434747599 0.193398388672406 no 2700 0.134141700899538 955 4182430
SGTC_869 0564-0080 44.1 µM -1.10706756165915 0.193389297698846 no 2701 0.134132359511538 943 6843321
SGTC_2220 6782180 200 µM -1.11210793611742 0.192330742876238 no 2702 0.133045872461281 945 833803
SGTC_284 0988-0104 32.6 µM -1.11233330808179 0.19228349426787 no 2703 0.132997433894855 957 4666532
SGTC_568 1193-0097 7.48 µM -1.11253027073823 0.192242207406095 no 2704 0.132955111203805 900 3646150
SGTC_1196 1588-0294 184 µM -1.1126690820053 0.192213113363327 no 2705 0.132925289463539 959 6144269
SGTC_459 nigericin 15.3 µM -1.11313469102985 0.192115544062129 no 2706 0.132825293237737 963 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_595 3909-8003 73.7 µM -1.11316033776162 0.192110170618947 no 2707 0.132819786739351 972 699517
SGTC_2225 6654152 15.4 µM -1.11328610045062 0.192083822445941 no 2708 0.13279278705407 923 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1623 st003709 20.3 µM -1.11508509491519 0.191707162465155 no 2709 0.132406979035971 946 16192618
SGTC_132 0417-1715 25.805 µM -1.11565277454213 0.191588399905404 no 2710 0.132285396327139 959 6769098
SGTC_643 k048-0106 28.4 µM -1.1181024453643 0.191076428622955 no 2711 0.131761621083965 967 6763920
SGTC_102 gallobenzophenone 83.616 µM -1.11989749259599 0.19070180417979 no 2712 0.131378723461624 931 70837
SGTC_3301 9125354 19.7965 µM -1.12072814407303 0.190528600770286 no 2713 0.131201799264913 937 41905162
SGTC_202 3594-0513 34.79 µM -1.12092143027225 0.190488311527427 no 2714 0.131160653979351 956 708429
SGTC_340 k038-0059 454 µM -1.12373605518057 0.189902214270707 no 2715 0.130562507942256 945 23733424
SGTC_417 st075190 100 µM -1.12389793088983 0.189868540185721 no 2716 0.130528164607382 969 222757
SGTC_2681 menadione 3.18 µM -1.12745985788687 0.189128502196177 no 2717 0.129774051708481 965 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_89 0302-0250 142.109 µM -1.12776551670916 0.189065080348023 no 2718 0.129709480036417 979 4203518 YLR208W SEC13
SGTC_1792 st045773 43.6 µM -1.12826323361827 0.188961835963205 no 2719 0.12960438293333 903 2919270
SGTC_249 wiskostatin 11.211 µM -1.13023743329731 0.188552658175717 no 2720 0.129188095185322 923 2775510 A n-wasp and actin depolymerizer.
SGTC_645 0845-0943 5.41 µM -1.13053934506521 0.188490131351258 no 2721 0.129124514652991 955 1885106
SGTC_873 0591-4978 488 µM -1.13094262098339 0.188406631659709 no 2722 0.129039621378656 963 3305145
SGTC_2898 9056270 58.44 µM -1.13172252727411 0.188245214068928 no 2723 0.128875553776753 907 19154699
SGTC_1613 st002381 52.1 µM -1.13209864438933 0.18816739943077 no 2724 0.128796482375878 951 551167
SGTC_1241 0364-0022 50.8 µM -1.13245748811459 0.1880931769801 no 2725 0.12872107375176 982 4563895
SGTC_3218 9131285 49.47 µM -1.13295734481108 0.187989817836531 no 2726 0.128616083251284 959 17156417
SGTC_3065 9113888 49.47 µM -1.13429768490765 0.187712838705723 no 2727 0.128334849977414 973 16648368
SGTC_1759 st043059 70 µM -1.13875754141739 0.186793032780992 no 2728 0.127402147676572 968 669426
SGTC_1614 st002383 48.6 µM -1.1396520744534 0.186608879695033 no 2729 0.127215640538133 937 1947235
SGTC_1043 0916-0009 19.3 µM -1.13985483578954 0.186567153856101 no 2730 0.127173391900776 965 3101130
SGTC_3257 9139206 32.98 µM -1.14048155760577 0.18643821859202 no 2731 0.127042865895476 963 4910041
SGTC_914 3820-6779 408 µM -1.14090115359993 0.186351926106107 no 2732 0.126955529662698 958 2893481
SGTC_2159 5658611 73.75 µM -1.14434348048307 0.185644925013677 no 2733 0.12624060892571 968 793844
SGTC_10 0279-0212 42.575 µM -1.14447034198281 0.185618901446125 no 2734 0.126214315371661 979 39851 YBR002C RER2
SGTC_1336 1486-0901 104 µM -1.1490103572842 0.184689081798383 no 2735 0.125275854949296 954 5006114
SGTC_2750 bromebric acid 70.15 µM -1.15033807909551 0.184417705423544 no 2736 0.125002326423608 975 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3143 9086658 49.47 µM -1.15553485786542 0.183357910231858 no 2737 0.123935733319947 943 25236626
SGTC_2877 9040724 71.43 µM -1.15875943067023 0.182702226143385 no 2738 0.123277129207764 967 6463895
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.16370974472726 0.181698483000136 no 2739 0.122270829488278 990 688798
SGTC_1568 digitonin 820 nM -1.16695636806984 0.181042063352714 no 2740 0.121613995160765 981 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1349 flufenamic acid 69 µM -1.16707756841703 0.181017587222744 no 2741 0.121589522854952 964 3371 A non-steroidal anti-inflammatory.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.16771965297775 0.180887954320182 no 2742 0.121459933359836 965 2333 A French combination drug.
SGTC_2126 5251174 33.877 µM -1.16876078855382 0.180677879182669 no 2743 0.121250011330462 973 790722
SGTC_3224 9130643 49.47 µM -1.16958486309712 0.180511710043568 no 2744 0.121084035874821 977 17644395
SGTC_2869 9037858 32.47 µM -1.17107771529345 0.180210930556822 no 2745 0.120783770209829 960 27187042
SGTC_1964 st076914 61 µM -1.17131760332257 0.180162627327925 no 2746 0.120735569113885 981 24208661
SGTC_1962 st076595 64.5 µM -1.17305133078758 0.17981377013467 no 2747 0.120387610942649 960 279619
SGTC_1766 st045414 44.774 µM -1.1741038220077 0.179602197074929 no 2748 0.120176721391135 951 253960
SGTC_1380 2291-0730 164 µM -1.17992609743597 0.178434624527553 no 2749 0.119014804590424 973 2999191
SGTC_2537 larixol 68.93 µM -1.18141818778776 0.178136178981668 no 2750 0.118718318149899 959 6708759
SGTC_2580 diallyl disulphide 81.36 µM -1.18292892027413 0.177834325448779 no 2751 0.118418659422684 954 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2208 7283366 200 µM -1.18325758894227 0.177768698206422 no 2752 0.118353537789587 946 898663
SGTC_1312 1218-2183 165 µM -1.18376017829103 0.177668372728734 no 2753 0.118254004887395 971 6744073
SGTC_1317 1273-0028 910 nM -1.18383705206163 0.177653030552782 no 2754 0.118238786009559 953 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2398 5228213 48.84 µM -1.18453652850016 0.177513470106447 no 2755 0.118100372672013 981 80771 YMR134W ERG29
SGTC_201 4262-0159 12.803 µM -1.18597720638522 0.177226242300252 no 2756 0.117815650572194 999 1341029
SGTC_667 1498-1044 59 µM -1.18881153161745 0.17666202048209 no 2757 0.117256919603557 984 6739982
SGTC_600 1495-0418 41.6 µM -1.19139945766656 0.176147841838851 no 2758 0.116748402871605 980 5377768
SGTC_296 1222-0039 74.9 µM -1.19275461275846 0.175878972928175 no 2759 0.11648274511374 974 5984176
SGTC_3134 9127454 49.47 µM -1.1959123562861 0.175253471391983 no 2760 0.115865381370263 988 24262820
SGTC_761 k216-0224 480 µM -1.1966689355532 0.175103814153651 no 2761 0.115717809821958 1008 1340404
SGTC_778 3456-2434 196 µM -1.20125351990089 0.174198682639561 no 2762 0.11482643718537 883 5539063
SGTC_2191 5911152 200 µM -1.2020770206131 0.174036415005178 no 2763 0.114666844287742 971 2875902
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.20289214311428 0.173875892929926 no 2764 0.114509030574947 973 551469
SGTC_3306 9127676 59.7925 µM -1.203041653422 0.173846460087062 no 2765 0.114480101066536 957 41905287
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.20559000031194 0.17334527571261 no 2766 0.113987808379132 989 521171
SGTC_3025 9087895 49.47 µM -1.20607880470321 0.173249247609065 no 2767 0.113893553220363 977 17173641
SGTC_467 ro 31-8220 72.8 µM -1.20692988230588 0.17308212994699 no 2768 0.113729574210746 977 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3204 9114183 49.47 µM -1.20731327825743 0.173006879848198 no 2769 0.113655759467398 956 17027248
SGTC_1152 3909-8331 15.9 µM -1.2091514725785 0.172646382357815 no 2770 0.113302328629546 961 16001939
SGTC_2605 digitonin 300 nM -1.20948529789755 0.17258096562402 no 2771 0.113238228021498 976 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_826 1683-5028 118 µM -1.21364047427333 0.171768036269591 no 2772 0.112442522121385 972 722377
SGTC_862 0452-0056 10.2 µM -1.21581224747903 0.171344119818217 no 2773 0.112028226097153 987 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1266 0828-0227 32.9 µM -1.21729996496843 0.171054113058671 no 2774 0.111745053818942 985 3913820
SGTC_3042 9091578 49.47 µM -1.22027998458148 0.170474150756092 no 2775 0.111179377349419 959 25236497
SGTC_3018 9082602 49.47 µM -1.22065195572173 0.17040184737253 no 2776 0.111108912841536 955 17332089
SGTC_515 4092-1064 102 µM -1.22714790278224 0.169142339067254 no 2777 0.109883503092438 1007 717353
SGTC_255 tunicamycin 200.472 nM -1.2307485654057 0.168446783254494 no 2778 0.109208458986409 955 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1807 st050092 58.9 µM -1.23147342949654 0.16830698079027 no 2779 0.109072924176038 986 5008496
SGTC_2593 nobiletin 86.24 µM -1.2335398993805 0.167908836436255 no 2780 0.108687200101671 960 72344 An anti-infammatory.
SGTC_334 1502-1024 68.5 µM -1.2348633666737 0.167654164281289 no 2781 0.108440679645013 988 3296216
SGTC_2852 9023854 51.95 µM -1.23667284271423 0.167306373245922 no 2782 0.108104282400689 981 19798528
SGTC_297 0986-0032 24 µM -1.23724244433513 0.167196989042851 no 2783 0.107998544164101 981 2847425
SGTC_2561 acetosyringone 100 µM -1.23801281094047 0.167049124026191 no 2784 0.107855655333438 982 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3028 9087778 49.47 µM -1.23941022871502 0.166781117399381 no 2785 0.107596807658413 965 17217395
SGTC_1058 3448-5425 97.3 µM -1.23983547361779 0.166699616020733 no 2786 0.107518127240187 982 7279705
SGTC_273 hydroxyurea 18.1 mM -1.24284814893852 0.166122950333479 no 2787 0.106961897895854 1000 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2368 9071271 200 µM -1.2443833198641 0.165829594697355 no 2788 0.106679259457158 984 27209959
SGTC_2286 7945697 125 µM -1.24729123406688 0.165274840197364 no 2789 0.106145365234013 979 1245733
SGTC_427 1354-0053 47.3 µM -1.24911032395202 0.164928416444368 no 2790 0.105812362552259 1007 6813657
SGTC_303 1348-1668 34.2 µM -1.24931539271072 0.164889393083465 no 2791 0.105774870070882 990 5380509
SGTC_101 0490-5701 117.494 µM -1.25005004645568 0.164749641948452 no 2792 0.105640633013416 962 4661669
SGTC_100 0086-0128 49.5915 µM -1.25185298442448 0.164406999402991 no 2793 0.105311719606754 987 93297
SGTC_1306 1185-0270 9.02 µM -1.25297485072417 0.164194025659645 no 2794 0.105107429698759 983 1548076
SGTC_2768 sulfasalazine 50.2 µM -1.25297486486503 0.164194022976289 no 2795 0.105107427125541 1001 5384001 An antioxidant and salicylic acid derivative.
SGTC_1620 st003704 16.5 µM -1.25328462673855 0.164135249692826 no 2796 0.105051070588503 985 2834414
SGTC_2069 5228469 200 µM -1.25418956627616 0.163963627366065 no 2797 0.104886555668544 990 2835210
SGTC_1315 1237-0019 3.69 µM -1.25453869766388 0.163897445525731 no 2798 0.10482313466439 961 825140
SGTC_2362 9071156 126 µM -1.25489781435642 0.163829388945048 no 2799 0.104757928767793 990 653133
SGTC_1797 st048695 56.8 µM -1.25894300558174 0.163064047622098 no 2800 0.104025459410835 970 592262 YIL048W NEO1
SGTC_1948 st076329 66.6 µM -1.26148258554992 0.16258475405327 no 2801 0.103567515157421 988 24208413
SGTC_1108 betulinic acid 729.144 nM -1.26176076690546 0.162532308790036 no 2802 0.103517441748817 976 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1237 0330-0133 46.1 µM -1.26191728361959 0.162502805684187 no 2803 0.103489276035218 990 X1237 YHR072W ERG7
SGTC_223 busulfan 5 mM -1.26378135071173 0.162151700471123 no 2804 0.103154258343272 974 2478 A DNA alkylator.
SGTC_813 k007-0158 173 µM -1.26393526357095 0.162122732402819 no 2805 0.103126631741242 990 6523916
SGTC_1552 6-methylflavone 10.6 µM -1.26494543511649 0.161932690819651 no 2806 0.102945444272128 986 689013
SGTC_1539 benzyladenosine 56 µM -1.26535712648835 0.161855281773975 no 2807 0.102871668413401 965 92208 A nucleotide analog.
SGTC_2655 perillic acid 100 µM -1.26703790389336 0.161539500627734 no 2808 0.102570868540208 1002 5702197 An apoptosis inducer.
SGTC_1050 3232-1156 69.3 µM -1.26718105551512 0.16151262415752 no 2809 0.102545279027414 985 700529
SGTC_845 0330-0138 4.51 µM -1.2683050351549 0.161301700238192 no 2810 0.102344519823288 980 9039800
SGTC_394 menadione 8.33 µM -1.26860420794022 0.161245588321903 no 2811 0.102291131386155 985 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1309 pyrazolanthrone 13.4 µM -1.27349842497917 0.160329452505395 no 2812 0.101420615553 989 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_917 harmaline 728.087 nM -1.27560149360271 0.159936831499244 no 2813 0.101048212929976 965 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3268 9137683 49.47 µM -1.27569567076818 0.159919264326007 no 2814 0.101031559777077 1035 1953228
SGTC_1219 1469-0211 33.1 µM -1.27673938213453 0.159724661944945 no 2815 0.100847136382977 984 6822282
SGTC_2344 7990960 76.95 µM -1.27979711991879 0.159155432002175 no 2816 0.100308248527818 951 140813
SGTC_609 0986-0026 86.3 µM -1.28024431847481 0.159072292822765 no 2817 0.100229611896023 965 2848610
SGTC_1434 4073-0095 163 µM -1.28160506944134 0.158819489142326 no 2818 0.0999906104772895 981 24133745
SGTC_1554 st069299 38.7 µM -1.28312440496978 0.158537534568835 no 2819 0.0997242474253595 981 24207999
SGTC_3278 9139605 49.47 µM -1.28503791212032 0.158182897956682 no 2820 0.0993895180412739 985 7958859
SGTC_2876 9059903 25.97 µM -1.28905712167615 0.157439701096934 no 2821 0.0986891144081111 984 6916095
SGTC_3293 9120939 62.045 µM -1.2891862621355 0.157415859695509 no 2822 0.0986666699272361 995 934087
SGTC_1989 st071868 50.2 µM -1.28947760228136 0.157362082344588 no 2823 0.0986160490277615 974 16414057
SGTC_1418 3966-3099 2.4 µM -1.29019775684071 0.157229203625702 no 2824 0.0984910023967219 975 740335
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.29045105487581 0.15718248409278 no 2825 0.0984470476890703 971 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1450 4112-4260 37.6 µM -1.29100079145056 0.157081119389015 no 2826 0.0983517015366264 977 1633175
SGTC_689 0833-0039 98 µM -1.29396202513443 0.15653584379365 no 2827 0.0978392691048078 992 5374726
SGTC_2486 5283202 22.39 µM -1.29851273214891 0.155700317813985 no 2828 0.0970556020379597 982 1377751
SGTC_1930 st074634 34.3 µM -1.29942332961667 0.155533482669548 no 2829 0.0968993448235207 992 684253 YOR116C RPO31
SGTC_3243 9134147 49.47 µM -1.30253176542222 0.154964859210362 no 2830 0.0963673331784826 981 24282180
SGTC_651 3253-0966 34.4 µM -1.30300991846727 0.154877513081127 no 2831 0.09628568770341 1002 781462
SGTC_1810 st050138 53 µM -1.30369864617661 0.154751757602144 no 2832 0.0961681756061138 1010 3444541
SGTC_64 000l-0018 272.079 µM -1.30495414911807 0.154522687698223 no 2833 0.0959542305235613 972 6811119
SGTC_2084 5306078 60.6385 µM -1.30515705903366 0.154485687285014 no 2834 0.095919686363125 998 679340
SGTC_128 0906-2981 13.371 µM -1.30655890638021 0.15423022188246 no 2835 0.0956812803475298 997 6740226
SGTC_987 1497-1013 404 µM -1.30764049560858 0.15403330971008 no 2836 0.0954976373883231 1002 1676435
SGTC_1435 4092-0789 56.7 µM -1.30837131439928 0.153900352373715 no 2837 0.0953736986626671 984 2248285
SGTC_856 0433-0016 11.3 µM -1.31304885012118 0.153051170824758 no 2838 0.0945832439571143 995 3911780
SGTC_168 3970-0862 530.542 µM -1.31351216021349 0.152967228741048 no 2839 0.0945052130333723 980 3135186
SGTC_145 3737-0113 38.366 µM -1.31383006094909 0.152909649446893 no 2840 0.0944516994905726 980 6849351
SGTC_2219 9098279 200 µM -1.31424314804665 0.152834851137856 no 2841 0.0943821962183576 985 902349
SGTC_700 3453-2283 142 µM -1.32205209059002 0.151425439117113 no 2842 0.0930754028520801 988 565664
SGTC_1891 st059073 26.2 µM -1.32331367287858 0.151198553530235 no 2843 0.0928655432993679 995 688754
SGTC_40 0327-0103 19.753 µM -1.324178766805 0.151043104010161 no 2844 0.0927218404603477 969 409036
SGTC_3287 9117173 37.0625 µM -1.32551697471859 0.15080284977464 no 2845 0.0924998715779302 949 2789709
SGTC_269 exalamide 29 µM -1.32976686940881 0.150041535687398 no 2846 0.0917975474719173 1000 3316 A derivative of salicylamide.
SGTC_2716 st080858 38.6235 µM -1.33141206993614 0.149747508320859 no 2847 0.0915267300315305 981 5296050
SGTC_93 0109-0045 59.227 µM -1.33151000932723 0.14973001689418 no 2848 0.0915106268631549 1009 88733
SGTC_1073 triclabendazole 3.09 µM -1.33258132522507 0.149538774874856 no 2849 0.0913346184744686 1002 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_245 methotrexate 289.6 µM -1.33328620227301 0.14941303529029 no 2850 0.0912189499374751 980 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1283 0922-0125 16.4 µM -1.33447818011709 0.149200564794711 no 2851 0.0910235965966288 976 3360884
SGTC_811 0416-0114 265 µM -1.33486952635887 0.14913085119915 no 2852 0.0909595265462787 973 6612453
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.33566213178021 0.148989724798975 no 2853 0.0908298660339796 979 5379071
SGTC_1502 4534-4282 27.7 µM -1.34454210752079 0.147414711617974 no 2854 0.0893865748339961 1022 3278949
SGTC_1657 st012939 43.4 µM -1.34606600792307 0.147145547951154 no 2855 0.089140614956611 984 24207257
SGTC_1895 st058434 18.3 µM -1.3487021852249 0.146680703339562 no 2856 0.0887163216800518 1021 5393175
SGTC_1304 1165-0502 251 µM -1.35021838018925 0.146413795210565 no 2857 0.0884729720586457 987 767425
SGTC_1372 2752-0194 270 µM -1.35107336929432 0.146263428391035 no 2858 0.0883359655985539 992 823334
SGTC_2885 9057732 51.95 µM -1.35222518221336 0.146061023219467 no 2859 0.0881516451038242 994 6471414
SGTC_1446 4239-0190 62 µM -1.35425575438107 0.145704654381495 no 2860 0.0878273984136763 1017 1340085
SGTC_3280 9140961 49.47 µM -1.35681785615668 0.145255835915939 no 2861 0.0874195462000147 1021 4901226
SGTC_628 1636-0253 16 µM -1.35985922857832 0.144724269463998 no 2862 0.0869372376079573 990 4456143
SGTC_1684 st024538 14.6195 µM -1.36200085939786 0.144350745550383 no 2863 0.0865988069500341 1012 6732859
SGTC_272 doxorubicin 8.13 µM -1.36250296242184 0.14426326738109 no 2864 0.0865196049408425 1006 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1597 7-benzyloxygramine 47.5 µM -1.36796223314741 0.143314440549089 no 2865 0.0856619490069653 985 260807
SGTC_1664 st014217 9.02 µM -1.37178782652199 0.142652065284476 no 2866 0.0850647490058849 975 3982782
SGTC_2447 5741742 33.78 µM -1.37261510418766 0.142509100473952 no 2867 0.0849360169123678 1003 1776504
SGTC_350 k064-0020 19.8 µM -1.37371494178194 0.142319183706905 no 2868 0.0847650981742985 951 2790705
SGTC_2361 9034121 116 µM -1.3786591923597 0.141467540624932 no 2869 0.0839999284763943 1021 6496917
SGTC_3286 9117135 37.221 µM -1.38053457417206 0.141145412900323 no 2870 0.0837110559892076 998 3438150
SGTC_1477 0139-0234 16 µM -1.38089181563822 0.141084107231714 no 2871 0.0836561133928686 1017 620880
SGTC_2978 9011784 42.97 µM -1.38102427759732 0.141061380224661 no 2872 0.083635748053459 973 2994934
SGTC_1692 fluoroquinolonic acid 71 µM -1.38107987474523 0.141051841948249 no 2873 0.0836272013901399 1003 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_866 0495-0101 262 µM -1.38602622432405 0.14020499380077 no 2874 0.0828694479900446 986 635694
SGTC_699 0375-0592 111 µM -1.38644807630978 0.140132930083826 no 2875 0.082805062437861 983 762578
SGTC_1609 st001574 46.4 µM -1.38944346647309 0.139621960230093 no 2876 0.0823489702960003 993 3960012
SGTC_2732 terfenadine 20 µM -1.39174588156874 0.139230064034745 no 2877 0.0819996815991246 1037 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_373 0844-0104 25.9 µM -1.39295592434708 0.139024401895008 no 2878 0.0818165597089687 994 5375804
SGTC_78 0336-0123 156.75 µM -1.394752135719 0.138719494473984 no 2879 0.0815452985624038 993 6765896
SGTC_298 1391-0729 10 µM -1.39620361273931 0.13847343880466 no 2880 0.081326594554647 1012 3237558
SGTC_2424 5537928 59.2 µM -1.39771719194713 0.138217172473662 no 2881 0.0810990047659633 990 5382802
SGTC_1534 6-azauridine 81.6 µM -1.40758226124367 0.136554826351042 no 2882 0.0796274015555347 1013 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1159 4092-0538 61.2 µM -1.40884875993199 0.136342405360042 no 2883 0.0794399468015647 1017 717301
SGTC_1514 1189-1591 158 µM -1.41171986819266 0.135861691898626 no 2884 0.0790162304407784 1019 767698 YMR146C TIF34
SGTC_442 cape 100 µM -1.41205542425565 0.135805585144679 no 2885 0.0789668212154678 1017 5281787
SGTC_1162 k048-0130 20.1 µM -1.4137854097271 0.135516574201976 no 2886 0.0787124593734579 1002 6797406
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.41532404130652 0.135259885126283 no 2887 0.0784867546198156 1011 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1696 st025591 34.7925 µM -1.4182810208455 0.134767510129647 no 2888 0.0780543677462853 992 2787147
SGTC_3329 9141233 27.5565 µM -1.41840505857937 0.134746883167834 no 2889 0.0780362697939181 982 4909101 YNL103W MET4
SGTC_2863 9028737 58.44 µM -1.41960410930534 0.134547597683642 no 2890 0.0778614842107061 1010 6460917
SGTC_2856 9022925 19.48 µM -1.42147710610884 0.134236705555035 no 2891 0.07758905227591 1011 4944862
SGTC_2597 laccaic acid a 100 µM -1.42328256105328 0.133937491826551 no 2892 0.0773271301327557 1018 5491415 A textile dye.
SGTC_3088 9117578 49.47 µM -1.42893681062321 0.133003393374368 no 2893 0.0765111980630536 1048 678341
SGTC_1403 3909-7815 62.9 µM -1.42965452027336 0.132885147187338 no 2894 0.0764080996972983 994 6615483
SGTC_3276 9139060 49.47 µM -1.43037843654508 0.13276595177488 no 2895 0.0763042168636771 1025 4870619
SGTC_244 nsc-207895 1.295 µM -1.43274555300545 0.132376711676821 no 2896 0.0759652831174822 987 42640
SGTC_546 peri-Naphthalide 147 µM -1.43428654544305 0.132123739492811 no 2897 0.0757452541149552 999 223824 A penicillin ester.
SGTC_1453 4237-0541 195 µM -1.4359972479582 0.131843298029704 no 2898 0.0755015621822066 982 739892
SGTC_2933 9026794 32.47 µM -1.44093588872585 0.131035994370371 no 2899 0.0748013979371512 1000 17586027
SGTC_1868 st057644 42.7 µM -1.44176050694796 0.130901530138826 no 2900 0.0746849738204763 1030 688665
SGTC_3320 9137005 35.139 µM -1.44512664501041 0.130353628794696 no 2901 0.0742111579958657 1015 4908713
SGTC_2063 5246145 200 µM -1.44564422715334 0.130269523631715 no 2902 0.0741385075016727 1018 711240
SGTC_1915 st067105 30.6 µM -1.4512346182977 0.129363498410742 no 2903 0.0733572701181977 1001 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_804 1595-0054 20.9 µM -1.45264491644862 0.129135625215404 no 2904 0.0731611841002248 1021 761523 Stimulates phospholipase C.
SGTC_438 sphingosine 6.67 µM -1.45431550285649 0.128866055411906 no 2905 0.0729294271434465 1024 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1101 ebselen 5.29 µM -1.45626466043511 0.128552028388764 no 2906 0.0726597354096263 1009 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2717 st081029 62.2815 µM -1.45864536198713 0.128169196712901 no 2907 0.0723313707787561 1003 5292846
SGTC_1881 5652484 16 µM -1.45903239837051 0.128107033749851 no 2908 0.0722780953760386 1023 2255129
SGTC_320 4092-0846 5.34 µM -1.46012341762227 0.127931914920528 no 2909 0.0721280788712815 1013 1359356
SGTC_3252 9135871 49.47 µM -1.46358649174345 0.127377161180784 no 2910 0.0716534828177431 1025 17682838
SGTC_1991 st073000 8.92 µM -1.46441700816207 0.127244368933279 no 2911 0.0715400218778092 1018 4301969 YIL048W NEO1
SGTC_3184 9108758 49.47 µM -1.47202276029031 0.126032755173963 no 2912 0.0705073657393747 1026 902885
SGTC_382 3229-0966 23.2 µM -1.47454024236329 0.125633492125123 no 2913 0.070168095455106 1033 5722370
SGTC_1974 st069448 26.9 µM -1.47572652922185 0.125445657785246 no 2914 0.0700086605526655 1008 6323587 YNR016C ACC1
SGTC_2056 5235370 200 µM -1.47812311875852 0.125066784692861 no 2915 0.0696874135644433 1007 5511916
SGTC_1198 1612-1005 86.7 µM -1.479679374032 0.124821187136752 no 2916 0.069479416308489 1018 6998509
SGTC_1942 st076330 65.2 µM -1.4812144390468 0.124579264025154 no 2917 0.0692747198735871 1016 24208414
SGTC_113 0099-0221 2.5 µM -1.48517770937041 0.123956176915177 no 2918 0.0687483775756944 1008 89219
SGTC_1871 st057448 67.3 µM -1.48616658445757 0.123801051092225 no 2919 0.0686175318878592 1030 691747
SGTC_3059 1327-0034 3 µM -1.4868006852578 0.123701650607219 no 2920 0.0685337302441966 1014 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.49035870463476 0.123144938453814 no 2921 0.0680649722327269 1009 756377
SGTC_1893 st059353 36.1 µM -1.49193149869449 0.122899408804738 no 2922 0.0678585520716858 1028 3112488
SGTC_331 k048-0133 24.5 µM -1.49561781492207 0.122325281856139 no 2923 0.0673766390102012 1031 6813582
SGTC_1074 carmofur 3.8 µM -1.49649256228458 0.122189320750875 no 2924 0.0672626723377522 1032 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2602 kawain 100 µM -1.49703342255039 0.122105308481332 no 2925 0.0671922808241162 1006 5369129
SGTC_783 0848-0141 92.7 µM -1.49740488401418 0.122047632566525 no 2926 0.0671439691126427 1021 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_193 1273-0060 1.558 µM -1.50069298380441 0.121537931460237 no 2927 0.0667174943120363 1012 2847393 YHR072W ERG7
SGTC_1206 3978-0017 132 µM -1.50134118147376 0.121437628633195 no 2928 0.0666336693329656 999 3873677
SGTC_577 r071-0003 38.6 µM -1.50145939667318 0.1214193421583 no 2929 0.0666183905254137 1043 4568517 YMR134W ERG29
SGTC_3147 9097027 49.47 µM -1.50398569400604 0.121029016915136 no 2930 0.0662925251679318 1025 25236841
SGTC_1100 amiodarone 5.07 µM -1.50683242727702 0.120590241595544 no 2931 0.065926807707382 1012 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2929 9013348 24.6 µM -1.51001513589645 0.120101008917052 no 2932 0.0655197810286559 1026 2995952
SGTC_1046 2001-0062 216 µM -1.51041201346583 0.12004010077953 no 2933 0.0654691625450483 1021 739778
SGTC_1558 st069300 45.6 µM -1.51071460580701 0.119993677067685 no 2934 0.0654305897511575 1004 24208000
SGTC_2059 5238311 157 µM -1.5160314462239 0.119180031565256 no 2935 0.0647557005520294 1013 703021
SGTC_2894 9048625 32.47 µM -1.5183712383594 0.118823205839925 no 2936 0.0644604190396171 1024 4092861
SGTC_891 0929-0073 133 µM -1.51924895623962 0.118689545904613 no 2937 0.0643499213431853 1034 5603632
SGTC_1296 1068-0102 11.9 µM -1.52129223002246 0.118378805275124 no 2938 0.0640932596233148 1023 767053
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.52231782290995 0.118223050295309 no 2939 0.0639647321853767 1023 16725076
SGTC_944 3370-0224 231 µM -1.52257855614458 0.118183476312455 no 2940 0.0639320890357711 1013 4580514
SGTC_1832 st054113 55 µM -1.52566791317451 0.117715287935907 no 2941 0.063546294690585 1022 1251267
SGTC_3353 9151644 39.2805 µM -1.52583306915965 0.117690295758987 no 2942 0.0635257213811041 1034 4909158
SGTC_2106 5357045 167.29 µM -1.52790467902232 0.117377129012691 no 2943 0.0632681031612545 1028 668842
SGTC_2522 biochanin a 4.94 µM -1.53238542545765 0.116701791096062 no 2944 0.0627136759245073 1027 5280373 A possible chelator.
SGTC_1130 3454-2858 15.9 µM -1.5325949245119 0.116670282962888 no 2945 0.0626878464147827 1018 715628 YIL048W NEO1
SGTC_965 1291-5240 308 µM -1.53426404185729 0.116419467350449 no 2946 0.0624823540531223 1027 2834598
SGTC_967 1306-0166 352 µM -1.53670702514428 0.116053054132651 no 2947 0.0621825350041207 1037 4437607
SGTC_2147 5545932 89.7195 µM -1.54391546403033 0.114976663050902 no 2948 0.0613044066610789 1043 797404
SGTC_151 3013-0144 2.285 µM -1.54566184888548 0.11471695822347 no 2949 0.061093127820668 1012 906558 YHR107C CDC12
SGTC_410 α-linolenic acid 100 µM -1.54571117408587 0.114709629140636 no 2950 0.0610871686984849 1034 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2818 7996756 12.99 µM -1.54795133714128 0.114377121174515 no 2951 0.0608170065777081 1043 2241621
SGTC_1070 indatraline 8.81 µM -1.54980546907857 0.114102431389356 no 2952 0.0605941069833473 1024 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2796 7949634 45.45 µM -1.55801032435615 0.112892522585628 no 2953 0.0596154003637245 1010 2971588
SGTC_550 4123-0385 25.7 µM -1.56129365302366 0.112410929388252 no 2954 0.0592272402294155 1039 5731123
SGTC_1168 k815-0004 80.5 µM -1.56340896522861 0.112101437394451 no 2955 0.0589782163920943 1038 642433
SGTC_1 0258-0098 57.368 µM -1.56353211903343 0.112083437504993 no 2956 0.0589637435285027 990 6790032 YDR047W HEM12
SGTC_1591 genipin 88.4 µM -1.56440048537633 0.111956577632648 no 2957 0.0588617734018266 1037 442424 A DNA cross-linking agent.
SGTC_106 0092-0003 11.579 µM -1.5719163233356 0.110862875135088 no 2958 0.0579849791929425 1023 1072148
SGTC_1995 st072814 61.1 µM -1.57313314239268 0.110686526412761 no 2959 0.0578439961045954 1033 5769371
SGTC_3060 1327-0027 12.5 µM -1.57372546623138 0.110600756070237 no 2960 0.0577754658643915 992 16000455 YPR107C YTH1
SGTC_1978 st071761 42 µM -1.57476454077027 0.110450409932196 no 2961 0.057655402024876 1024 5147680
SGTC_278 4092-0821 23.9 µM -1.57503521827164 0.110411269035593 no 2962 0.0576241577943342 1040 877900
SGTC_1374 2889-5571 141 µM -1.57894181575053 0.109847468866184 no 2963 0.0571747017392968 1013 2853281
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.58672380020544 0.108730536753986 no 2964 0.0562876067454564 992 279621
SGTC_1572 epiandrosterone 68.9 µM -1.58864652601404 0.108455834528107 no 2965 0.0560701089395574 1026 441302 A steroid.
SGTC_846 0335-0850 148 µM -1.59121261791711 0.10808999219165 no 2966 0.0557808670794464 1030 6819598
SGTC_1346 1488-2224 62.4 µM -1.59468341311944 0.107596582906844 no 2967 0.0553915245245112 1017 3722427
SGTC_2408 sulbentine 18.36 µM -1.59575389270341 0.107444731183146 no 2968 0.0552718755430563 1002 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1383 3049-0032 20.7 µM -1.60258573179084 0.106479245743682 no 2969 0.0545130729664833 1025 712864
SGTC_81 0411-0046 9.971 µM -1.60384358593236 0.106302168905565 no 2970 0.0543742672218694 1020 12925265
SGTC_2438 5259590 200 µM -1.60430322326429 0.106237515661446 no 2971 0.0543236154857632 1039 1201127
SGTC_2688 kanamycin b 96.69 µM -1.6058627017923 0.106018368847852 no 2972 0.0541520401002544 999 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1607 st000305 50.6 µM -1.60780036021913 0.105746533344314 no 2973 0.0539394547711866 1029 5457690
SGTC_1097 itavastatin 7.23 µM -1.61554121391037 0.104665590844182 no 2974 0.0530967713502848 1041 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_990 3985-0011 41.3 µM -1.6208114074601 0.103934247833717 no 2975 0.052529045626639 1016 5399565 YGL099W LSG1
SGTC_1264 0783-0040 158 µM -1.62423940734451 0.103460538970083 no 2976 0.0521623617287241 1022 2855798
SGTC_29 0299-0004 12.984 µM -1.62465971449383 0.103402565538806 no 2977 0.0521175428682845 1030 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2991 9074669 71.4286 µM -1.62475090880555 0.103389990120064 no 2978 0.0521078225310173 1023 17333109
SGTC_1729 st035615 45.989 µM -1.63111898317337 0.102514595526617 no 2979 0.0514326079307369 1015 17385451
SGTC_384 k007-0144 5.16 µM -1.63236068415866 0.102344533339898 no 2980 0.0513017631668346 1035 6824886
SGTC_1794 st048918 76.9 µM -1.63261642107427 0.102309533349007 no 2981 0.0512748476951512 980 672303
SGTC_1280 0880-0253 10.1 µM -1.63526830722698 0.101947110963356 no 2982 0.0509964071503466 1029 6836607
SGTC_556 4058-0063 51.5 µM -1.63584239614973 0.101868775765448 no 2983 0.0509362881980675 1044 6615692
SGTC_454 lyso-paf C-16 6.67 µM -1.63906017057376 0.101430517028768 no 2984 0.0506003644928632 1032 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_794 k038-0031 316 µM -1.64114511826161 0.101147282747025 no 2985 0.0503836474668586 1024 6624242
SGTC_3333 9141820 12.094 µM -1.64418237494704 0.10073571203648 no 2986 0.0500692682330124 1018 1939433
SGTC_142 0335-0849 62.6745 µM -1.64945252680153 0.100024468158804 no 2987 0.0495274806313359 1011 3889043 YPR107C YTH1
SGTC_2921 7974240 10.71 µM -1.65375525863769 0.0994465089129894 no 2988 0.0490886249999595 1035 2979074 YDR527W RBA50
SGTC_2323 6148992 148.28 µM -1.65549409566253 0.0992136356103368 no 2989 0.0489121565570238 1018 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_150 3970-0969 77.2 µM -1.65888306410517 0.0987609152944676 no 2990 0.0485696789866224 1029 6615640
SGTC_1183 1254-0324 198 µM -1.66370157979082 0.0981198323741986 no 2991 0.0480860402140289 1029 5799357
SGTC_68 0986-0284 82.829 µM -1.66778479246507 0.0975789692153113 no 2992 0.0476792279154134 1006 423278 YIL048W NEO1
SGTC_1540 guanosine 70.6 µM -1.6680157369857 0.0975484437145619 no 2993 0.0476563014179642 1035 6802 Guanosine is a purine nucleoside
SGTC_2567 aureobasidin a 60 nM -1.66849008233745 0.0974857682431869 no 2994 0.0476092395420442 1022 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_690 glyoxal 20.3 µM -1.66922225630902 0.0973890837441105 no 2995 0.0475366704427605 1031 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1861 st057647 17.4 µM -1.68352548543526 0.0955144114233152 no 2996 0.046136705010957 1047 688668
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.68477681544184 0.095351676292308 no 2997 0.0460158198142395 1034 688788
SGTC_1859 st055998 20 µM -1.68572445647467 0.0952285717194948 no 2998 0.045924442023808 1041 676301
SGTC_2330 7979373 200 µM -1.68656869885573 0.0951189978947263 no 2999 0.0458431574694216 1022 1863007
SGTC_1840 st055363 71 µM -1.68726155064269 0.0950291423792621 no 3000 0.0457765353737511 1060 676033
SGTC_1774 st048371 48.465 µM -1.69241304614536 0.094363008109019 no 3001 0.0452836232986889 1050 4242727
SGTC_1697 st025554 27.742 µM -1.69340507605723 0.0942351261743666 no 3002 0.0451891946736381 1041 1269519
SGTC_2969 9091408 28.7 µM -1.6946530625681 0.0940744306618831 no 3003 0.0450706273318182 1037 4286311
SGTC_669 0108-0021 26.2 µM -1.70228354563483 0.0930962957807032 no 3004 0.0443511139081734 1039 17201
SGTC_1209 2323-2347 50.3 µM -1.71037631185526 0.0920671370588258 no 3005 0.0435981542491086 1020 5412760
SGTC_103 0844-0104 51.839 µM -1.71431554286122 0.0915692429925972 no 3006 0.0432353950554946 1015 5375804
SGTC_402 epigallocatechin gallate 10 µM -1.71433709544133 0.0915665243810479 no 3007 0.0432334170289788 1026 65064 An antioxidant.
SGTC_3064 1327-0027 10 µM -1.71453113088306 0.0915420517218256 no 3008 0.0432156123704642 1033 16000455 YPR107C YTH1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.71662605678672 0.0912781384627233 no 3009 0.0430237592023837 1022 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1652 st011932 78 µM -1.71869468743579 0.0910180917643947 no 3010 0.0428349899499165 1027 1551076
SGTC_3292 9120825 59.784 µM -1.72352675476723 0.0904127963372273 no 3011 0.0423966555923313 1022 24824900
SGTC_3080 9117754 49.47 µM -1.72403769402576 0.090348967993743 no 3012 0.0423505193123478 1037 9550191
SGTC_3104 9120930 49.47 µM -1.72881847605866 0.0897533564070785 no 3013 0.0419207941685547 1042 17014836
SGTC_254 nsc-64875 3.808 µM -1.73537443237604 0.0889413381611069 no 3014 0.0413372528491419 1048 56993
SGTC_1356 1502-0781 85.8 µM -1.73539760384353 0.088938477883395 no 3015 0.0413352021088965 1042 567702
SGTC_3209 9113616 49.47 µM -1.73604645199379 0.0888584121015124 no 3016 0.0412778106933394 1040 16649353
SGTC_312 4092-0653 6.84 µM -1.74264098225702 0.0880477105229412 no 3017 0.040698173319839 1017 1148278
SGTC_1526 st051518 75 µM -1.7435066945865 0.0879416946089446 no 3018 0.0406225729634227 1038 673993
SGTC_1516 st013856 110 µM -1.74379814224657 0.0879060250919848 no 3019 0.0405971472746538 1056 5281404 A mutagen and neurotoxin.
SGTC_2766 oltipraz 83.91 µM -1.7464061967072 0.0875873122870788 no 3020 0.0403701969724477 981 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_983 1491-0821 12.2 µM -1.74759114059869 0.0874427934572725 no 3021 0.0402674252628986 1046 46495113
SGTC_2135 5326629 150.42 µM -1.7502167839928 0.087123197419323 no 3022 0.040040456869652 1048 5020077
SGTC_904 1141-0088 396 µM -1.75226394253078 0.0868746209874409 no 3023 0.039864216560904 1058 1378119
SGTC_1724 st037281 8.293 µM -1.75477527021778 0.0865704069520324 no 3024 0.039648877597999 1027 574124 YDL195W SEC31
SGTC_2111 5486399 200 µM -1.75879802259457 0.0860847643470537 no 3025 0.0393059103927053 1038 689674
SGTC_1677 st019204 53.9 µM -1.76761212670804 0.0850278207221033 no 3026 0.038562884655828 1047 3945625
SGTC_322 k048-0136 19.3 µM -1.76796459361757 0.084985757801149 no 3027 0.0385334114852143 1060 6823282
SGTC_2 0422-0095 29 µM -1.76981718615833 0.0847649283386777 no 3028 0.0383787999739837 1026 6790840
SGTC_727 3032-0951 202 µM -1.77222777120167 0.0844782305906016 no 3029 0.0381783777166279 1059 3652836
SGTC_3302 9125395 16.351 µM -1.77311550914484 0.0843728328761077 no 3030 0.038104784286616 1040 17599668
SGTC_2348 9022543 33.42 µM -1.77659288167237 0.083960927942765 no 3031 0.0378176238393109 1022 3162678 YDL140C RPO21
SGTC_1994 st072947 40.9 µM -1.77926147686541 0.0836458504783875 no 3032 0.0375984517869403 1050 5286565 YDL195W SEC31
SGTC_2904 7225135 42.03 µM -1.78020959584927 0.0835341214770206 no 3033 0.0375208327853499 1068 4446116
SGTC_452 diindolylmethane 8 µM -1.78265691694329 0.0832462406895055 no 3034 0.0373210842883908 1050 3071 Inhibits expression of several cancer promoting factors.
SGTC_985 1493-0307 8.71 µM -1.78914975276391 0.0824860972033998 no 3035 0.0367953506894714 1053 3278274
SGTC_837 0091-0265 12.5 µM -1.79438803576133 0.0818766474305279 no 3036 0.0363756276096074 1059 759367
SGTC_2258 7960471 200 µM -1.79771906935557 0.0814908661364526 no 3037 0.0361107689728412 1065 2974708
SGTC_2009 4012297 12.05 µM -1.80046757753357 0.0811735830865897 no 3038 0.0358934193243166 1026 45595307
SGTC_1275 0867-0008 21.1 µM -1.80179421372004 0.0810207724305849 no 3039 0.0357888942263924 1058 3422836
SGTC_2128 5255449 168.493 µM -1.80220583285834 0.0809734036003214 no 3040 0.0357565136761661 1029 736008
SGTC_941 3237-0776 460 µM -1.80523075492533 0.0806259388494402 no 3041 0.0355192900915996 1054 760008
SGTC_3308 9128332 17.569 µM -1.80541631594331 0.0806046606648623 no 3042 0.0355047799372818 1047 17332805 YDL196W YDL196W
SGTC_1932 st074806 40.9 µM -1.80692123255332 0.0804322493273159 no 3043 0.0353872807253314 1037 17251235
SGTC_2533 agelasine 13.65 µM -1.80866442720832 0.0802328880352962 no 3044 0.0352515763222474 1038 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2737 bleomycin 30.5 nM -1.81487999454111 0.0795250810122494 no 3045 0.0347711767723997 1046 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_824 1304-0008 100 µM -1.82019043814569 0.0789240980619289 no 3046 0.0343650043747703 1053 768245
SGTC_1619 st003326 88.7 µM -1.82115565099413 0.0788152353709621 no 3047 0.0342915998899837 1006 2849032
SGTC_1740 st038286 13.222 µM -1.8310316477579 0.0777078882102827 no 3048 0.0335479097502905 1041 716786
SGTC_1496 4469-0713 57.4 µM -1.83770029070434 0.0769668724578627 no 3049 0.0330532905094331 1066 746691
SGTC_580 1123-0028 41 µM -1.83833136749275 0.0768970267095429 no 3050 0.0330067958264968 1064 1677248 YPR107C YTH1
SGTC_3156 9099931 49.47 µM -1.83872584031113 0.076853392081057 no 3051 0.0329777603617538 1066 18111053
SGTC_2421 5690543 90.72 µM -1.84754032551101 0.0758832800301474 no 3052 0.0323344346545966 1051 3397993
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.84936147874808 0.0756840134545628 no 3053 0.032202816934881 1059 4174840
SGTC_1824 st053723 68.6 µM -1.85682763264094 0.0748712485158506 no 3054 0.0316678405125199 1047 675225
SGTC_1716 st033144 30.6155 µM -1.85707499569815 0.0748444349984398 no 3055 0.0316502425257724 1052 674617
SGTC_2731 amoxapine 43.43 µM -1.85909115947023 0.074626161174817 no 3056 0.0315071090799598 1081 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2776 terbinafine 19.92 µM -1.85968219213591 0.0745622669985658 no 3057 0.0314652514797988 1034 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1785 bathophenanthroline 24 µM -1.86094883736999 0.0744254756958754 no 3058 0.0313757010560461 1000 72812 An iron chelator.
SGTC_966 1300-0360 30.2 µM -1.86243902937079 0.0742647878674704 no 3059 0.0312706160299909 1010 70588
SGTC_2401 5128683 200 µM -1.86412776541465 0.0740830113766 no 3060 0.0311518821274629 1056 708373
SGTC_2659 sanguinarine 24.21 µM -1.86879384286282 0.0735825192308439 no 3061 0.0308257509112558 1010 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_107 0358-0022 2.6945 µM -1.87876407358918 0.0725217623932026 no 3062 0.0301383572934609 1068 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_683 panaxydol 45 µM -1.88172457937785 0.0722090533183572 no 3063 0.0299367103353312 1062 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_617 3770-0098 35 µM -1.88504547774753 0.0718595080426821 no 3064 0.0297118490566392 1055 5962639
SGTC_1393 3470-5649 58.2 µM -1.8875722961879 0.0715944150583152 no 3065 0.0295416960968895 1058 4108395
SGTC_337 1315-0038 354 µM -1.89443134387758 0.0708786030038063 no 3066 0.0290838896613878 1062 1626437
SGTC_2166 5933061 31.504 µM -1.90191101523659 0.0701043029455517 no 3067 0.0285913944412613 1068 2877375
SGTC_2229 7354935 190 µM -1.90297441836207 0.0699947491599045 no 3068 0.0285219416690493 1062 318112
SGTC_2124 5246320 200 µM -1.90541853169523 0.0697434513549031 no 3069 0.0283628440923596 1054 579342
SGTC_330 1488-0319 80.1 µM -1.91089471152686 0.069182925526666 no 3070 0.028009056416888 1047 6846614
SGTC_890 0929-0006 47.2 µM -1.91301209540066 0.0689671291522017 no 3071 0.0278732520137631 1067 1378169
SGTC_601 0986-0029 62.9 µM -1.9183817202923 0.06842220203476 no 3072 0.0275313135858767 1036 24747981
SGTC_370 0180-0345 38.7 µM -1.91910555188611 0.0683490000208589 no 3073 0.0274854884978381 1029 3989527
SGTC_1789 tunicamycin 25 nM -1.92864405931689 0.0673899947520043 no 3074 0.0268875326777212 1029 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_294 k038-0071 157 µM -1.93364653584049 0.0668912186717519 no 3075 0.0265783007390292 1071 24152826
SGTC_2587 piperic acid 92.2 µM -1.94213282158101 0.0660516243227116 no 3076 0.0260605115291465 1052 5370536
SGTC_1129 3453-1384 223 µM -1.94399071530183 0.0658689068500316 no 3077 0.0259482853754439 1061 1084452
SGTC_425 3825-7017 13.1 µM -1.94699227028821 0.0655745421679157 no 3078 0.0257678306892718 1057 3397440
SGTC_3349 9149703 23.001 µM -1.94748801310165 0.065526022610491 no 3079 0.0257381277299409 1064 4910494
SGTC_475 α-linolenic acid 10 µM -1.95395823854103 0.0648953158267711 no 3080 0.0253530781003335 1051 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2280 7785178 200 µM -1.95402748959586 0.0648885909315038 no 3081 0.0253489831450879 1052 2954328
SGTC_198 3454-2873 16.191 µM -1.9557661523396 0.0647199285122932 no 3082 0.0252463539350413 1062 710957
SGTC_2186 6124449 200 µM -1.96571141232206 0.0637617042067076 no 3083 0.0246659778963242 1057 3834182 YLR033W RSC58
SGTC_646 4092-0839 27.3 µM -1.96609812909204 0.0637246682252525 no 3084 0.0246436382432208 1056 877796
SGTC_1232 0279-0259 161 µM -1.96626483666023 0.0637087077543784 no 3085 0.024634013205039 1056 1560000
SGTC_1018 4259-0013 28.1 µM -1.98136505996799 0.0622758788539461 no 3086 0.0237751745581981 1058 6801262
SGTC_2763 lisinopril 49.32 µM -1.98217420844542 0.0621998157500438 no 3087 0.0237298731310031 1049 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_63 0099-0242 26.702 µM -1.98345550192978 0.0620795174382393 no 3088 0.0236582864044335 1068 3898502 YLR359W ADE13
SGTC_2301 7769476 200 µM -1.98472335938049 0.061960659371009 no 3089 0.0235876292099169 1046 977820
SGTC_1239 0337-0584 35.4 µM -1.98517570585181 0.0619182961715904 no 3090 0.0235624631166303 1057 914301 YML130C ERO1
SGTC_3160 9100216 49.47 µM -1.98803810273164 0.0616507505618279 no 3091 0.0234037380445235 1062 17191039
SGTC_1658 st012944 20 µM -1.98887195272953 0.0615729813855454 no 3092 0.0233576691316563 1060 24207260
SGTC_1581 himbacine 57.9 µM -1.99162912973207 0.0613163781236144 no 3093 0.0232058824072868 1075 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3170 9103054 49.47 µM -2.00207207687256 0.0603520488173276 no 3094 0.0226384900854119 1042 16432970
SGTC_2305 7443522 69.23 µM -2.0051652523883 0.0600687070425149 no 3095 0.0224726917323948 1049 5415886
SGTC_381 3461-2219 42.7 µM -2.00757316100634 0.0598488591156114 no 3096 0.0223443344868332 1075 2883159
SGTC_2099 5377090 177.372 µM -2.01130374885206 0.0595094926573257 no 3097 0.0221466913874273 1058 2243829
SGTC_1909 st060837 51.5 µM -2.01508997030019 0.0591666093588083 no 3098 0.0219476114750139 1041 678937
SGTC_1153 4055-0057 267 µM -2.01527976849945 0.0591494619472113 no 3099 0.0219376717650552 1057 882706
SGTC_2256 7954252 200 µM -2.01739836180332 0.0589583210635276 no 3100 0.0218269790489754 1072 2972920
SGTC_165 k038-0023 64.381 µM -2.01752811515749 0.0589466303974916 no 3101 0.0218202150256306 1067 46368543
SGTC_796 1234-0020 70.7 µM -2.02099784734247 0.0586346845915739 no 3102 0.0216399939659658 1052 46495034
SGTC_3108 9121785 49.47 µM -2.02315872534999 0.0584410669506558 no 3103 0.0215283927804558 1007 17140271
SGTC_3000 9075062 71.4286 µM -2.03205839084485 0.0576489320493354 no 3104 0.0210738725282508 1038 17057871
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.03792802707502 0.0571311294579251 no 3105 0.0207785656042887 1056 5024745
SGTC_2046 4110841 106 µM -2.03856730558658 0.0570749559065286 no 3106 0.0207466155154742 1058 44119630 YMR134W ERG29
SGTC_1725 st036284 20.55 µM -2.04102533073819 0.0568593735661301 no 3107 0.0206241546791571 1048 707914
SGTC_539 4859-0462 2.54 µM -2.04464806131439 0.0565428098199026 no 3108 0.0204447837947829 1049 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1644 st010134 20.9 µM -2.0517976241359 0.055922138416186 no 3109 0.0200946671550585 1073 3818134
SGTC_1268 0828-0275 2.46 µM -2.05481476669142 0.0556618307528384 no 3110 0.0199484496886618 1074 745337
SGTC_1133 3473-0247 50 µM -2.05585457367519 0.0555723420368982 no 3111 0.0198982679247905 1033 711311
SGTC_3084 9116877 49.47 µM -2.06287676879287 0.0549709620397772 no 3112 0.0195621689162442 1067 27241325
SGTC_1188 1403-0014 4.57 µM -2.06804510224919 0.0545316409109915 no 3113 0.0193178910849111 1058 9614867
SGTC_376 3970-0862 59.1 µM -2.06968139688773 0.0543931320069367 no 3114 0.0192410949848906 1063 3135186
SGTC_2278 7948257 134.34 µM -2.07667366486436 0.0538043841994122 no 3115 0.0189158444080361 1063 1247028
SGTC_3009 9080819 71.4286 µM -2.08460798718733 0.0531424399425132 no 3116 0.0185524494427449 1073 17027216
SGTC_2669 eugenol 100 µM -2.08492889657358 0.053115803596407 no 3117 0.0185378776078254 1071 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2919 7978188 46.38 µM -2.09089437688336 0.0526225774291935 no 3118 0.0182687666440563 1069 2980291
SGTC_158 k038-0087 26.446 µM -2.10364834039101 0.0515802736461686 no 3119 0.0177045669307765 1054 X158
SGTC_1686 st019653 115.5 µM -2.10533589995288 0.0514435979385006 no 3120 0.017631039609898 1083 97252
SGTC_2384 9036245 200 µM -2.10701123022093 0.0513081977438306 no 3121 0.0175583030660058 1058 6462766
SGTC_2216 7189485 200 µM -2.11262506931945 0.0508565528592354 no 3122 0.0173164356321574 1076 731273
SGTC_2049 5262831 67.185 µM -2.1132900555851 0.0508032636761203 no 3123 0.017287974678877 1053 763417
SGTC_584 0986-0246 15.4 µM -2.11522534109606 0.0506484310408941 no 3124 0.0172053730544688 1073 53315 YDR232W HEM1
SGTC_137 0438-0332 85.389 µM -2.1180730495536 0.0504212836185014 no 3125 0.017084440784742 1055 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_506 n9-isopropylolomoucine 153 µM -2.12536740861523 0.0498431506988863 no 3126 0.0167779837816878 1074 6610355
SGTC_3073 9114972 49.47 µM -2.13170664779568 0.0493450236817157 no 3127 0.0165154849908977 1074 41905075
SGTC_2066 5222451 176 µM -2.13255785028555 0.0492784413148867 no 3128 0.0164805070482117 1021 2281147
SGTC_2413 inermin 26.06 µM -2.13601636597854 0.049008648466981 no 3129 0.0163390399322235 1039 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2701 st077767 14.721 µM -2.13815912197289 0.0488420886490206 no 3130 0.0162519154205845 1065 5721188
SGTC_2224 6650123 117.647 µM -2.14638090905986 0.0482071899548928 no 3131 0.0159213005919025 1088 2908370
SGTC_1076 itraconazole 331 nM -2.16326138750029 0.0469243550436828 no 3132 0.0152605405555551 1078 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_637 1181-0519 7.26 µM -2.1691778929857 0.0464812627579177 no 3133 0.0150345904164424 1057 6252091 YGR060W ERG25
SGTC_892 0929-0076 29 µM -2.17450364922623 0.046085290086734 no 3134 0.014833665821234 1072 5751038
SGTC_1522 st012842 45.6 µM -2.17828758048461 0.0458056028370134 no 3135 0.0146923166072281 1019 3491067 YOR116C RPO31
SGTC_99 0109-0120 622.8 µM -2.18921902430464 0.0450052677297168 no 3136 0.0142904622779418 1071 759414
SGTC_1014 4130-3005 69.3 µM -2.19796477021637 0.0443730937879624 no 3137 0.0139758082885163 1074 743608
SGTC_1959 st077091 55.8 µM -2.201992981689 0.0440843370156 no 3138 0.0138329021145564 1068 821356 YKL052C ASK1
SGTC_3063 1327-0034 4 µM -2.20340282363824 0.0439836330897011 no 3139 0.0137831846811201 1063 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1033 k072-0102 21.3 µM -2.20470724471285 0.0438906246000504 no 3140 0.0137373222153281 1062 5965931
SGTC_1338 1486-1223 76 µM -2.20573055470025 0.0438177711286545 no 3141 0.0137014356078344 1067 3444526
SGTC_1734 st037168 69.4 µM -2.20879770050565 0.0435999931587701 no 3142 0.0135943575347833 1072 708907
SGTC_318 1488-0629 67.2 µM -2.21389645312776 0.043239897809706 no 3143 0.0134179513968696 1080 3662576
SGTC_2647 atorvastatin 60.16 µM -2.22620049489277 0.0423808208298677 no 3144 0.0130003774192763 1070 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.22848728874104 0.0422226869884095 no 3145 0.0129240190247973 1075 23665772 A membrane-active detergent.
SGTC_953 1188-0045 9.7 µM -2.24328160123278 0.0412111484790953 no 3146 0.0124393305297491 1062 6144426
SGTC_922 1866-0035 480 µM -2.24331617217686 0.0412088079587037 no 3147 0.0124382166155899 1051 3156169
SGTC_2198 6589944 200 µM -2.24456196421024 0.0411245372952585 no 3148 0.0123981334179562 1067 5290268
SGTC_3300 9124615 50.48 µM -2.24483032916797 0.0411064022553139 no 3149 0.0123895134710945 1077 24824903
SGTC_3319 9138450 16.7555 µM -2.25388873786287 0.0404980649330134 no 3150 0.0121015841797917 1060 2029690
SGTC_2167 5876490 200 µM -2.25653923419153 0.0403214537317023 no 3151 0.0120184405329514 1072 686534
SGTC_533 1222-0222 6.71 µM -2.25979537688833 0.0401053431039332 no 3152 0.0119169767374986 1075 3982874
SGTC_444 curcumin 90.4 µM -2.26507479509095 0.0397569480722071 no 3153 0.0117540450248075 1055 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2206 7254556 146.969 µM -2.27278353422919 0.0392526626896117 no 3154 0.0115196138897641 1080 4398905
SGTC_984 1492-0255 2.91 µM -2.27332647292727 0.0392173421946038 no 3155 0.0115032566857626 1082 1585198
SGTC_1170 0310-0127 64.8 µM -2.281718691758 0.0386746749256451 no 3156 0.0112529769029557 1083 774975
SGTC_2140 5586273 200 µM -2.28531435324777 0.0384440478875512 no 3157 0.0111472009570924 1084 854421
SGTC_1086 cerivastatin 2.18 µM -2.29151623081134 0.0380488922666431 no 3158 0.0109667871139478 1071 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_661 1304-0007 33.6 µM -2.29223529980729 0.0380032915576902 no 3159 0.0109460345124808 1082 3117130
SGTC_664 1222-0054 14.9 µM -2.30556083596312 0.0371662743233521 no 3160 0.0105675918817958 1079 6813991
SGTC_540 1187-0821 17.3 µM -2.31289697654372 0.0367119370026781 no 3161 0.0103641520512024 1075 847520
SGTC_2704 st078022 71.1 µM -2.3132268981766 0.036691611714757 no 3162 0.0103550837144017 1079 54697681
SGTC_448 monastrol 171 µM -2.31524624744927 0.0365674073417712 no 3163 0.0102997298017664 1079 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1321 1326-2144 215 µM -2.31746575778077 0.0364312886711893 no 3164 0.0102391869337384 1080 3513030
SGTC_2090 5301565 104.445 µM -2.3191363277434 0.0363291092870864 no 3165 0.0101938227787629 1080 2056344
SGTC_3121 9125696 49.47 µM -2.33300698327788 0.0354897484126916 no 3166 0.00982388940248347 1091 1235365
SGTC_1165 k072-0275 30.3 µM -2.33432629156932 0.0354107474637414 no 3167 0.00978932153177121 1077 6153523 YGL055W OLE1
SGTC_2201 6605497 169.863 µM -2.34454535521194 0.0348036966090851 no 3168 0.00952514668481 1086 670741
SGTC_1161 k007-0610 110 µM -2.34657113587148 0.0346843782179445 no 3169 0.00947352453134568 1055 5843850
SGTC_2245 6637752 200 µM -2.34879138315657 0.0345539918234487 no 3170 0.00941722801797994 1077 681890
SGTC_2834 9001755 58.44 µM -2.36254523478718 0.0337552274071858 no 3171 0.00907496314683607 1061 2989575
SGTC_409 arachidonic acid 100 µM -2.37182818162958 0.0332247492598609 no 3172 0.00885015983207534 1075 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2971 9092186 9.93 µM -2.3742064776665 0.0330899510787412 no 3173 0.0087933564144009 1064 25236400
SGTC_2612 dictamnine 15.46 µM -2.37745782461013 0.0329063990941194 no 3174 0.00871621818950497 1056 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.38798631075104 0.0323177729137611 no 3175 0.00847048639558296 1077 7104
SGTC_393 acivicin 6.25 µM -2.38983369271247 0.0322153910543617 no 3176 0.00842800180661141 1033 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2038 4100038 30.985 µM -2.3963774053914 0.0318548901135315 no 3177 0.00827901574023714 1052 3596803
SGTC_2389 9091542 195.52 µM -2.40092579042247 0.0316062823718036 no 3178 0.00817682630173791 1075 3626624 YOL127W RPL25
SGTC_960 1222-0186 7.7 µM -2.40831996107842 0.0312055519781325 no 3179 0.00801306432811016 1078 3126296
SGTC_551 k048-0028 34.9 µM -2.41992348670681 0.030585172397627 no 3180 0.00776188655010823 1066 6836383
SGTC_1494 4358-1428 177 µM -2.4300275049805 0.0300533164950845 no 3181 0.00754883852247168 1083 1564571
SGTC_2799 7812892 81.82 µM -2.43638801478866 0.0297224615484535 no 3182 0.00741738102695487 1060 20205235
SGTC_1842 st055362 61.2 µM -2.43789578696772 0.0296444763940847 no 3183 0.00738651611280256 1087 676032
SGTC_2478 5763493 32.33 µM -2.44986384304174 0.029031467427267 no 3184 0.00714551217965189 1075 1365576 YLR208W SEC13
SGTC_673 1082-0474 110 µM -2.45453049396212 0.028795311316445 no 3185 0.0070534349677429 1069 3098046
SGTC_1757 st041620 31.8375 µM -2.45490572018134 0.0287763925451672 no 3186 0.00704607710060996 1082 5289815
SGTC_218 alverine citrate 93.75 µM -2.45646354643683 0.0286979579886857 no 3187 0.00701560184176908 1076 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2218 6965428 192.983 µM -2.45725709897479 0.0286580720291641 no 3188 0.00700012259785089 1079 675684
SGTC_1656 st012921 11 µM -2.45869294494603 0.0285860199517781 no 3189 0.00697219121815515 1080 6732821
SGTC_2765 myclobutanil 7.74 µM -2.46611533429539 0.0282159562075804 no 3190 0.0068293673306346 1084 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2725 haloperidol 53.21 µM -2.47071426294161 0.0279886712188763 no 3191 0.00674217566067012 1077 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2858 9025781 8.96 µM -2.47311053291438 0.0278708499803731 no 3192 0.00669713544071864 1063 4894980 YPL153C RAD53
SGTC_2511 berberine 10.47 µM -2.50077236060847 0.026540423878777 no 3193 0.00619614022031248 1071 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_46 0329-0187a 2.197 µM -2.50368599238124 0.0264034308047158 no 3194 0.0061453530628985 1066 46494817
SGTC_1936 st074407 74.3 µM -2.52037850931 0.0256299265764341 no 3195 0.00586143493543616 1079 809813
SGTC_1322 1348-1070 12 µM -2.52418460807938 0.025456239449381 no 3196 0.00579835059481769 1085 6758089
SGTC_1081 sertraline 6 µM -2.52597372926871 0.0253749361047969 no 3197 0.00576890543328268 1076 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_610 4215-0184 155 µM -2.5286771411698 0.0252524972206328 no 3198 0.00572466469253583 1064 5605015
SGTC_3123 9126162 49.47 µM -2.52943829296109 0.0252181137155831 no 3199 0.00571226306235899 1074 25239884
SGTC_2464 5717415 7.67 µM -2.53197713987906 0.0251037099372362 no 3200 0.0056710692758148 1087 5285744
SGTC_2453 5731132 22.18 µM -2.54526276344567 0.0245121136865095 no 3201 0.0054597767242378 1079 1362040
SGTC_1265 0819-1001 68.8 µM -2.54679881874583 0.0244444754432225 no 3202 0.00543580443550934 1084 3106768
SGTC_2068 5226020 147 µM -2.5586487643814 0.0239279266319069 no 3203 0.00525399248336021 1082 1810509
SGTC_709 3807-1509 243 µM -2.5636478909703 0.0237127784601078 no 3204 0.00517892816143592 1086 1886677 YPL242C IQG1
SGTC_2534 helenine 20.12 µM -2.56765438479161 0.0235415267197296 no 3205 0.00511945922503117 1075 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2519 cryptotanshinone 88.04 µM -2.56803746031874 0.023525207343162 no 3206 0.00511380514548309 1058 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2248 tofa 1.1 µM -2.56847222896223 0.023506697321909 no 3207 0.00510739482624443 1069 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2666 tannic acid 100 µM -2.57047919112295 0.0234214108214893 no 3208 0.00507789639187475 1080 16134267 A thiamine antagonist.
SGTC_1455 4262-0120 131 µM -2.57605902300139 0.0231856612179625 no 3209 0.00499667929833446 1083 1529587
SGTC_2338 7999974 200 µM -2.58376729623618 0.0228632730418613 no 3210 0.00488638535754511 1064 315925
SGTC_2651 TUB2.036 5 µM -2.587348330393 0.0227147907904971 no 3211 0.00483588821205207 1063 15992207 YFL037W TUB2
SGTC_2948 9070189 9.45 µM -2.60172782376293 0.0221267247984996 no 3212 0.00463777169482676 1068 6473636 YDL196W YDL196W
SGTC_2735 sertaconazole 140 nM -2.6138515659348 0.0216409434413083 no 3213 0.00447639611908612 1091 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3107 9121808 49.47 µM -2.63405708330812 0.0208513665561988 no 3214 0.00421856509913705 1082 662681
SGTC_692 k241-0027 77.8 µM -2.639184776338 0.0206549152165692 no 3215 0.00415528352754361 1083 3600480
SGTC_2243 6634756 200 µM -2.6473414447381 0.0203456492257277 no 3216 0.00405636968365052 1077 885676
SGTC_1250 0485-0349 40.2 µM -2.65289771847098 0.0201372340561574 no 3217 0.0039902024561959 1078 6842794 YDL195W SEC31
SGTC_2253 7938677 135.83 µM -2.65665239684355 0.0199974239831329 no 3218 0.00394603856016883 1088 2301972
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.6601116292663 0.0198693448854389 no 3219 0.00390573785251675 1090 442882
SGTC_2016 5121758 140 µM -2.66664217477038 0.0196294466362503 no 3220 0.00383065968601227 1083 2795203
SGTC_1510 1123-0200 71.5 µM -2.68189876538874 0.0190785672099973 no 3221 0.003660280456488 1087 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2736 butenafine 14.65 µM -2.68562471232357 0.0189460471119115 no 3222 0.00361971759816123 1086 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_470 aa-861 153 µM -2.7012044800553 0.0184003737144619 no 3223 0.00345444238566324 1085 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_423 5-fluorouracil 457 µM -2.70255126008237 0.018353838434793 no 3224 0.00344047867613134 1075 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2350 9023895 38.85 µM -2.70282102009037 0.0183445294809143 no 3225 0.00343768784902868 1069 2997209
SGTC_1556 plumbagin 1.48 µM -2.70545817527329 0.0182537374554212 no 3226 0.00341051185946078 1044 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2037 5169046 200 µM -2.71079760440992 0.0180710834590723 no 3227 0.00335607918102928 1092 5718022
SGTC_372 0155-0182 15.9 µM -2.73314780745274 0.0173233333357927 no 3228 0.00313660867886686 965 771486
SGTC_2913 7966556 36.57 µM -2.73987234739755 0.0171035940033227 no 3229 0.00307315255004149 1064 2976516
SGTC_2109 5483026 200 µM -2.76478530815121 0.0163101480223419 no 3230 0.0028480135547411 1086 759335
SGTC_1784 st039334 36.3 µM -2.76935095955034 0.016168208773505 no 3231 0.0028084047792584 1081 3496984
SGTC_1733 st037357 54.9 µM -2.76972572990749 0.0161566048701193 no 3232 0.00280517567867328 1080 1272339 YGL099W LSG1
SGTC_2781 5567276 71.43 µM -2.79236553244641 0.0154687268467825 no 3233 0.00261621051319746 1081 2853274
SGTC_329 k048-0121 21.3 µM -2.79327627899706 0.0154415893125976 no 3234 0.00260885535366176 1095 6832902
SGTC_765 1319-0117 244 µM -2.79331249480377 0.0154405110349126 no 3235 0.00260856326258713 1080 3487746 YGL099W LSG1
SGTC_2382 9035899 200 µM -2.80622319061349 0.0150602083058163 no 3236 0.00250629796890182 1088 6462679
SGTC_237 nikkomycin 200 µM -2.81361593211866 0.0148460904834269 no 3237 0.00244938591747173 1094 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_97 0535-0701 19.132 µM -2.81994289013405 0.014664925223029 no 3238 0.0024016098544497 1068 2832013 YGL099W LSG1
SGTC_1104 tacrolimus 29.8 µM -2.83721917714093 0.0141798960126222 no 3239 0.00227541800753412 1078 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_395 anisomycin 6.25 µM -2.84076950488743 0.0140819514100974 no 3240 0.00225024138361728 1090 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_718 1130-0073 349 µM -2.84109036944879 0.0140731283606019 no 3241 0.00224797850178039 1085 6740020
SGTC_398 bronopol 33.3 µM -2.85133833546598 0.0137938276502137 no 3242 0.00217678090985019 1085 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1698 5-fluorocytosine 1.055 µM -2.86002469829734 0.013560843865247 no 3243 0.00211804007830716 1087 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2791 5663188 71.43 µM -2.86138891177294 0.0135245635540042 no 3244 0.00210894645306816 1084 54690634
SGTC_450 aminopyrene 156 nM -2.86698886424328 0.013376513208534 no 3245 0.002071987967338 1090 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1025 k007-0731 70 µM -2.87857313445138 0.0130746875865993 no 3246 0.00199739321761987 1090 6256118
SGTC_2816 7982706 58.44 µM -2.88567839238607 0.012892489052639 no 3247 0.00195285521921685 1086 2981853
SGTC_1313 1220-0047 237 µM -2.89438392382849 0.0126722517934927 no 3248 0.00189951671176864 1079 3528706
SGTC_607 4491-0986 66.8 µM -2.90859345058 0.0123197642575443 no 3249 0.00181529325271257 1065 698981 YDR232W HEM1
SGTC_2289 7946404 165.07 µM -2.90941838731429 0.0122995639950091 no 3250 0.00181050957016253 1086 1246120 YPR165W RHO1
SGTC_363 0455-0021 3.06 µM -2.91204766003536 0.0122353722445668 no 3251 0.0017953392210472 1068 4597466
SGTC_2077 5212015 200 µM -2.91403593811393 0.012187022871707 no 3252 0.00178394415231733 1084 780900
SGTC_1605 st000082 49.1 µM -2.94820168960891 0.011381708536299 no 3253 0.00159814228096968 1079 1114022
SGTC_2139 5578692 56.4705 µM -2.96120361782943 0.0110876169184932 no 3254 0.00153219636309431 1074 650991 YMR113W FOL3
SGTC_764 1951-2361 146 µM -2.98628211572456 0.010538988857208 no 3255 0.00141195996773205 1087 5438930
SGTC_280 3448-3607 3.04 µM -3.00596116813495 0.0101251928140391 no 3256 0.00132371402263007 1075 626179
SGTC_2316 5844804 197.44 µM -3.02093809293291 0.0098198384489709 no 3257 0.0012599643785468 1082 776813
SGTC_706 4262-0057 46.9 µM -3.03199277137392 0.00959964105993189 no 3258 0.00121472510862303 1092 883298
SGTC_2041 5107442 45.335 µM -3.04747484854408 0.00929851416276365 no 3259 0.00115386418844425 1089 793005
SGTC_3343 9148379 18.9835 µM -3.04800779813989 0.00928829709947767 no 3260 0.00115181974656898 1084 1955036
SGTC_344 k064-0035 6.43 µM -3.05173217940323 0.00921717157159244 no 3261 0.00113762504446327 1072 5088750
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -3.05249132548487 0.00920273257854342 no 3262 0.0011347514524592 1086 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1490 4089-0339 670 nM -3.05408290195434 0.00917252497268602 no 3263 0.00112874843927789 1090 742542
SGTC_246 cycloheximide 667 µM -3.05609420273919 0.00913447531239546 no 3264 0.00112120395461185 1090 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3316 9136639 10.545 µM -3.07257870716012 0.00882779557836175 no 3265 0.00106108930301139 1088 4903665
SGTC_2396 5342950 42.78 µM -3.07946671697388 0.00870234745136711 no 3266 0.00103685769727977 1069 1886677
SGTC_642 0335-0876 158 µM -3.09196644836548 0.00847868374546154 no 3267 0.000994176607368824 1091 6812350
SGTC_3339 9145883 14.936 µM -3.09272123799518 0.00846534091305018 no 3268 0.000991651697107341 1074 2030670
SGTC_2179 6298986 200 µM -3.09856019285488 0.00836274370292595 no 3269 0.000972317313647155 1066 738374
SGTC_2973 9094665 17.96 µM -3.11479230916673 0.00808324106270796 no 3270 0.000920372346951344 1085 25237061 YIL048W NEO1
SGTC_2937 9044753 11.33 µM -3.12926179013073 0.00784104532248689 no 3271 0.000876230498798539 1086 6465530 YGL099W LSG1
SGTC_1057 3448-5381 134 µM -3.15247924343306 0.00746575168336388 no 3272 0.000809451653909886 1077 5497911
SGTC_1492 4158-0558 28.5 µM -3.15574170105589 0.0074143049283731 no 3273 0.000800452819471647 1091 3967268
SGTC_2307 7538926 6.34 µM -3.15660104115882 0.00740080580386598 no 3274 0.000798097873811021 1085 96582
SGTC_1469 k284-2957 126 µM -3.17862176639076 0.00706219838706242 no 3275 0.000739885244948666 1062 23884841
SGTC_2375 9072683 200 µM -3.18396170787717 0.00698217619120429 no 3276 0.000726371143134298 1092 16798029
SGTC_1955 wogonin 32.4 µM -3.18730253106838 0.00693251997048753 no 3277 0.000718032402174886 1084 5281703 A flavanone.
SGTC_2083 5306046 65.942 µM -3.19224467833297 0.00685963432141673 no 3278 0.00070585845532873 1092 539837
SGTC_1944 st076371 56.9 µM -3.19919516508025 0.00675827555006532 no 3279 0.0006890592081715 1090 24208455
SGTC_1191 1487-1166 10.6 µM -3.20150685807187 0.00672485867137759 no 3280 0.000683554104193372 1090 3955771
SGTC_1407 3909-7909 12.3 µM -3.20904137491273 0.00661695412445752 no 3281 0.000665891629615557 1083 4411780
SGTC_2696 st077691 74.316 µM -3.21270369970221 0.00656505966488542 no 3282 0.000657459335624416 1085 757133
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -3.21300195321963 0.00656084935918732 no 3283 0.000656776981346184 1088 5377381
SGTC_2227 7312221 64.1025 µM -3.23822767583816 0.00621327812946934 no 3284 0.000601373921415641 1095 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3222 9128301 49.47 µM -3.24540332850338 0.00611743519651573 no 3285 0.000586421892658676 1074 4911358
SGTC_1855 st056195 39.6 µM -3.28480030967848 0.00561420165753192 no 3286 0.00051027337200689 1081 4028379
SGTC_1330 1469-0054 61.8 µM -3.28905150801433 0.00556216008429863 no 3287 0.0005026281256166 1083 7102664
SGTC_1718 roemerine 11.9335 µM -3.30133364038689 0.00541420611734858 no 3288 0.000481131903344764 1068 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2018 5133068 143 µM -3.3093144217636 0.00531995255587867 no 3289 0.000467623716507923 1086 785362
SGTC_1635 st007035 42.4 µM -3.31303296369993 0.00527653679869743 no 3290 0.000461450509275895 1086 3716403
SGTC_3032 9089427 49.47 µM -3.31732600196692 0.0052268057020708 no 3291 0.000454417521501859 1067 17173707
SGTC_1475 4092-1048 11.7 µM -3.31960262138628 0.00520060262977932 no 3292 0.00045072832809248 1095 2881759
SGTC_2272 7805186 180 µM -3.3223593880011 0.00516902974445658 no 3293 0.000446298233301563 1087 2956062 YPR165W RHO1
SGTC_2974 9094440 9.66 µM -3.3274622931837 0.00511103668003316 no 3294 0.000438204244786195 1091 25236134
SGTC_819 1013-0258 27.7 µM -3.34634537655522 0.00490144083643629 no 3295 0.000409421669645297 1091 5753198
SGTC_420 mitomycin C 81.9 mM -3.34715928781269 0.00489258141143444 no 3296 0.000408221410483529 1093 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_135 0933-0004 26.348 µM -3.35462714556316 0.00481195758577149 no 3297 0.00039736011044348 1092 21230617 YGL099W LSG1
SGTC_2100 5377183 190 µM -3.3655364567012 0.00469630817024938 no 3298 0.000381974855572779 1084 2844202
SGTC_2779 methotrexate 400 µM -3.38161023154381 0.0045304269801456 no 3299 0.000360311568366831 1076 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2640 pentamidine 10.38 µM -3.412944066686 0.00422202824296831 no 3300 0.000321325653640001 1069 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3189 9110682 49.47 µM -3.43150448574546 0.00404833425434513 no 3301 0.000300121601604168 1090 17122418
SGTC_3345 9148410 3.559 µM -3.45935711745029 0.00379967102798055 no 3302 0.000270733236508 1089 4903596
SGTC_3340 9146634 11.102 µM -3.46732794148295 0.00373107462246366 no 3303 0.000262830074034972 1092 4907387
SGTC_1404 3909-7820 48.3 µM -3.47237865184711 0.00368818543238841 no 3304 0.000257934084393794 1081 23741373
SGTC_635 k038-0028 24.7 µM -3.48628020525544 0.00357241213279944 no 3305 0.000244893842287806 1094 4035102
SGTC_618 k072-0232 33.2 µM -3.55368073047429 0.00305606051661037 no 3306 0.000189940040145576 1082 5872756 YGL099W LSG1
SGTC_3124 9127567 49.47 µM -3.55638666174892 0.00303681061500439 no 3307 0.000187995288776238 1095 17592030
SGTC_1844 rapamycin 4 nM -3.55920151165172 0.00301690183936542 no 3308 0.000185992020164281 1080 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1638 st008370 60.6 µM -3.57861099595367 0.00288279374279029 no 3309 0.00017271258146579 1088 24207134
SGTC_810 3825-7150 143 µM -3.58198084726915 0.00286006553382392 no 3310 0.000170499398980972 1087 22330411 YGL099W LSG1
SGTC_2404 5161160 200 µM -3.59144149879875 0.00279711863681165 no 3311 0.000164427000128102 1089 2831543
SGTC_1600 coumarin 106 71.1 µM -3.60746166267752 0.00269337283213638 no 3312 0.000154603603770378 1094 100336 A hepatotoxic, DNA x-linker.
SGTC_768 0384-0033 77.3 µM -3.61035678127281 0.00267499922967208 no 3313 0.000152888053074397 1088 3965305 YMR134W ERG29
SGTC_1775 st081588 35.1725 µM -3.62101776368891 0.00260831207923486 no 3314 0.000146723181733655 1080 1426443 YGL099W LSG1
SGTC_62 0180-0423 3.232 µM -3.62104773299272 0.00260812674995257 no 3315 0.000146706184487918 1092 30102 YGL099W LSG1
SGTC_1493 4348-0038 111 µM -3.63215566868505 0.00254024940399685 no 3316 0.000140531739164914 1094 800424
SGTC_1019 4262-0212 3.4 µM -3.65832391747922 0.00238661187999303 no 3317 0.000126935033519924 1092 4677213
SGTC_1406 3909-7906 11.9 µM -3.66495518007377 0.00234903860294381 no 3318 0.000123690950884183 1085 X1406
SGTC_2217 6934799 96.0675 µM -3.70048029896996 0.00215671822746137 no 3319 0.000107595893135436 1091 675606
SGTC_1327 1436-0082 2.18 µM -3.72264258373966 0.00204408864199631 no 3320 9.85742545677395e-05 1093 15992205
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -3.72771367420876 0.00201907958439056 no 3321 9.66123604872661e-05 1092 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2689 tacrolimus 100 µM -3.74509521424981 0.00193545249631142 no 3322 9.01626868473822e-05 1083 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1156 4092-0367 4.88 µM -3.7964731820836 0.00170632694324778 no 3323 7.33846159384402e-05 1094 1357585
SGTC_3249 9135183 49.47 µM -3.81936185696534 0.00161243935514885 no 3324 6.68986825464922e-05 1083 4902779
SGTC_1328 1441-0025 69.2 µM -3.86401947026217 0.00144268219014549 no 3325 5.576816265554e-05 1095 4562601
SGTC_2977 9011197 71.43 µM -3.95918439240814 0.00113406470012374 no 3326 3.76030783290707e-05 1095 2704722
SGTC_2233 sulbentine 40.3845 µM -3.99827297060273 0.00102583559107857 no 3327 3.19031706255071e-05 1078 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1547 harmine 94.2 µM -4.03201698824875 0.000940115368244786 yes 3328 2.76500942873124e-05 1086 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1143 3454-2408 5.08 µM -4.03453936893909 0.000933979770809908 yes 3329 2.73547585466552e-05 1093 X1143
SGTC_1405 3909-7894 12 µM -4.11403403531794 0.000758472104647925 yes 3330 1.94402035679764e-05 1087 7104060
SGTC_676 falcarinol 140 µM -4.16983690196542 0.000654006619068441 yes 3331 1.5240885169294e-05 1093 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1715 st032160 10.2275 µM -4.18569805456653 0.00062683563779815 yes 3332 1.42145528963383e-05 1094 5289825
SGTC_894 0960-0238 55.9 µM -4.20338085531121 0.000597775078377359 yes 3333 1.31478795679154e-05 1091 6741907 YDL195W SEC31
SGTC_1827 berberine 7.24 µM -4.44853487763709 0.000304089328395935 yes 3334 4.32290057950907e-06 1088 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_490 phenamil 164 µM -4.49599018658191 0.00026577450337912 yes 3335 3.46234650544253e-06 1060 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2507 purpurin 79.67 µM -4.51327705711376 0.000252972261155243 yes 3336 3.19167728911183e-06 1093 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1880 MG-132 525 µM -4.87535932392107 8.65812252990142e-05 yes 3337 5.43052866324936e-07 1090 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -5.03115560147174 5.33705982424089e-05 yes 3338 2.43766127296569e-07 1093 688669
SGTC_177 1327-0068 8.361 µM -5.15357425156444 3.61460725341205e-05 yes 3339 1.27783906488098e-07 1093 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1941 st076221 61.8 µM -5.17092067478602 3.4181039144951e-05 yes 3340 1.16471721475043e-07 1095 2828568
SGTC_1010 4112-3296 15.2 µM -5.22968041809589 2.82493350085329e-05 yes 3341 8.49016585105552e-08 1095 704384
SGTC_2950 9072895 21.46 µM -5.2602029916647 2.55668994573223e-05 yes 3342 7.19482289402671e-08 1094 17332245
SGTC_1269 0831-0796 3.05 µM -5.29401686965546 2.28775984679575e-05 yes 3343 5.98291937005771e-08 1094 927758
SGTC_1476 4112-3294 3.34 µM -5.30332722291969 2.21856125603392e-05 yes 3344 5.68554129514457e-08 1093 704369
SGTC_1829 berberine 14.4 µM -5.56098965115987 9.30079566667199e-06 yes 3345 1.34124552895618e-08 1090 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2679 rapamycin 1 nM -5.97006196558113 2.16632232816864e-06 yes 3346 1.18581747525883e-09 1094 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_779 1360-0071 233 µM -6.21889377235872 8.52500175067262e-07 yes 3347 2.50336053315457e-10 1095 7566
SGTC_2499 avocadenofuran 51.48 µM -6.46967128590431 3.21411492516407e-07 yes 3348 4.91081702184813e-11 1095 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2739 tacrine 100.86 µM -6.58439509401207 2.03275323381773e-07 yes 3349 2.28370540959382e-11 1090 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_720 r052-1644 49.9 µM -6.92478058741776 4.99527649669398e-08 yes 3350 2.1832587998089e-12 1095 1422863 YOR257W CDC31
SGTC_367 0335-0881 7.1 µM -7.27240265157041 1.11283950703609e-08 yes 3351 1.76574535529691e-13 1094 23828853
SGTC_1786 berberine 21.6 µM -7.31195119296117 9.33984598950564e-09 yes 3352 1.31645376695752e-13 1094 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.