SGTCid condition conc unit KAR2|YJL034W.score KAR2|YJL034W.strain.pval KAR2|YJL034W.strain.significant KAR2|YJL034W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_69 0096-0274 206.684 µM 6.3663932659127 1.42328316724181e-12 yes 1 9.67624290652897e-11 19 6741392 SGTC_1635 st007035 42.4 µM 6.29427442317947 2.4969303007465e-12 yes 2 1.54420516974197e-10 4 3716403 SGTC_1620 st003704 16.5 µM 5.97463733263322 2.79938046979301e-11 yes 3 1.15301302111024e-09 1 2834414 SGTC_1629 st005085 44.9 µM 5.36808715713707 1.96956670325095e-09 yes 4 3.97880493791623e-08 6 24207091 SGTC_1636 st007707 68.9 µM 5.36753426630586 1.97682579661306e-09 yes 5 3.99101733924377e-08 5 403051 SGTC_1908 st060353 56.5 µM 4.95689183103739 2.75031057754622e-08 yes 6 3.58149143134936e-07 5 4227716 SGTC_67 0335-0847 266 µM 4.32835708552911 1.05400436944907e-06 yes 7 7.51128821588529e-06 16 4552207 YOR254C SEC63 SGTC_680 0417-1641 114 µM 4.22134615556977 1.87256561812642e-06 yes 8 1.21423836320946e-05 6 2835990 SGTC_514 4466-0038 2.65 nM 4.19651616030133 2.13561124746017e-06 yes 9 1.3552606490144e-05 34 5722064 SGTC_1604 st002052 72.4 µM 4.07927810409423 3.93409838294973e-06 yes 10 2.25878836744078e-05 7 6254834 YHR062C RPP1 SGTC_1286 0929-0070 131 µM 4.07812059021257 3.95758426756549e-06 yes 11 2.27006088988218e-05 5 1420408 SGTC_3346 9158254 43.5805 µM 3.97525107849171 6.67508663426497e-06 yes 12 3.51525223560316e-05 12 17639500 SGTC_2801 7907800 81.82 µM 3.70199584551871 2.52132948434314e-05 yes 13 0.000106955060874959 7 6620925 SGTC_1616 st002734 56.1 µM 3.66045143641744 3.06263168386353e-05 yes 14 0.000125885635714856 8 4026101 SGTC_1812 st052057 4.327 µM 3.59436355547938 4.15601914112099e-05 yes 15 0.000162592752457153 11 3645418 SGTC_474 dl-dihydrosphingosine 5 µM 3.38567198898568 0.000105440832928071 yes 16 0.000355020997817279 14 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1849 st056239 19.2 µM 3.31568912754236 0.000142473644932402 yes 17 0.000457087299262645 9 5393181 SGTC_513 4245-1575 41.7 µM 3.26298822993927 0.0001780615479095 yes 18 0.000551220491874496 49 719745 SGTC_1506 4226-2149 212 µM 3.25566696236445 0.000183617254892275 yes 19 0.000565631804934174 11 991114 SGTC_1284 0929-0043 16 µM 3.23766388337646 0.000197975635643887 yes 20 0.000602563502677771 11 1239883 SGTC_1528 arabinosylhypoxanthine 74.6 µM 3.21093243952251 0.000221241323934545 yes 21 0.000661525180515187 16 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1073 triclabendazole 3.09 µM 3.11646280172768 0.000325507831242731 yes 22 0.000915173854056475 7 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3324 9138759 60.749 µM 3.05355383960296 0.000418584602813649 yes 23 0.00113074068904113 13 45595710 SGTC_1288 0973-0013 65.5 µM 3.04849939049646 0.000427045229916062 yes 24 0.00114993689693467 5 4315430 SGTC_2431 5490079 200 µM 3.04039790718188 0.000440937737369421 yes 25 0.00118132888618053 17 5722345 SGTC_1789 tunicamycin 25 nM 3.02095161324217 0.000476012032879972 yes 26 0.00125990812012291 29 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1642 st009582 77.7 µM 3.005827788855 0.000505057709431379 yes 27 0.00132429476819949 19 6739311 SGTC_1085 doxorubicin 7.67 µM 2.9683901906866 0.000584159038287362 yes 28 0.00149682022344466 20 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1090 efavirenz 20.7 µM 2.94497708310816 0.000639291223072629 yes 29 0.00161489292146098 15 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2360 9040895 200 µM 2.87939253997558 0.000820312581005849 yes 30 0.0019922102919961 20 4914414 SGTC_3231 9132313 49.47 µM 2.86889962711423 0.000853310660992733 yes 31 0.00205951244741535 15 4905967 SGTC_758 0868-0029 16 µM 2.85248211779648 0.000907397130228969 yes 32 0.00216896265184272 8 762687 SGTC_1952 st077036 64.1 µM 2.84652941557848 0.000927773895816191 yes 33 0.00220993227817944 27 2937007 SGTC_2499 avocadenofuran 51.48 µM 2.8434791252568 0.000938377502348672 yes 34 0.00223119662091937 14 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1181 1222-0449 220 µM 2.80158369057012 0.00109573077378221 no 35 0.00254262246215773 14 658318 SGTC_184 1494-0393 24.714 µM 2.78742341242241 0.00115415764951157 no 36 0.00265645055076596 57 3090647 SGTC_2955 9076254 12.21 µM 2.77153691323956 0.00122309434985368 no 37 0.00278961730327317 19 16459619 SGTC_1133 3473-0247 50 µM 2.7561177014182 0.0012935870258897 no 38 0.00292459722913931 75 711311 SGTC_1608 st001473 40.5 µM 2.74639726031509 0.00133991548655025 no 39 0.00301268773348384 28 7292267 SGTC_969 1313-0238 134 µM 2.73066854101631 0.00141810091353866 no 40 0.00316030026547228 54 5212874 SGTC_1891 st059073 26.2 µM 2.71394597608156 0.00150577688795526 no 41 0.00332435039337913 17 688754 SGTC_1200 1643-0193 18.4 µM 2.71011768676706 0.00152653173913988 no 42 0.00336296692049596 18 5403974 SGTC_603 3794-0023 45.9 µM 2.67804052917713 0.00171095947397582 no 43 0.0037027128498178 10 3802260 SGTC_2692 st077426 47.7 µM 2.66345944470792 0.00180131703819115 no 44 0.00386708670397098 27 25238571 SGTC_459 nigericin 15.3 µM 2.64242876648007 0.00193929723149198 no 45 0.00411568890713957 28 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.63239779432725 0.00200843322946499 no 46 0.00423922641679894 15 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_572 0960-0087 17.7 µM 2.59747225706472 0.00226695982481782 no 47 0.0046956353136885 41 6796365 SGTC_3348 9149464 3.537 µM 2.5959434015814 0.00227893655738013 no 48 0.00471658012477816 8 1951442 SGTC_2711 st079103 59.1 µM 2.58753123390277 0.0023458669211042 no 49 0.00483332157139537 14 54693780 SGTC_360 0957-0399 1.01 µM 2.57730429522456 0.00242963042105757 no 50 0.00497871247187404 35 6752301 YPR165W RHO1 SGTC_1665 st014639 11.4 µM 2.5769226734226 0.00243280781476507 no 51 0.00498421239775777 22 981133 YIL048W NEO1 SGTC_1602 st001878 87.6 µM 2.57075885319997 0.00248465132148344 no 52 0.0050737979682703 40 595405 YLR310C CDC25 SGTC_857 0438-0306 1.35 µM 2.50818473373867 0.00307036245303358 no 53 0.00606766024375236 21 4686136 SGTC_1822 st052468 42 µM 2.50058012297413 0.00314942968085383 no 54 0.00619950412674481 14 2873678 SGTC_259 usnic acid 108.925 µM 2.48896080436128 0.00327378164109337 no 55 0.00640585446778324 33 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2807 7945238 51.95 µM 2.46315769143335 0.00356585517361263 no 56 0.00688596651902805 29 17148797 SGTC_934 2950-0684 338 µM 2.441191551538 0.00383270463170136 no 57 0.00731944385518391 26 1121253 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.43862535491093 0.00386501915583262 no 58 0.00737162213777082 30 4174840 SGTC_2983 9022671 12.99 µM 2.3995907263282 0.00438757257766557 no 59 0.00820670591888962 28 6405161 SGTC_487 nimodipine 119 µM 2.39156590188984 0.0045025163436443 no 60 0.00838833589576734 11 4497 L-type voltage-gated calcium channels inhibitor SGTC_2164 5685496 200 µM 2.38560162262188 0.00458967997594821 no 61 0.00852560534084958 28 759046 SGTC_763 3453-1109 128 µM 2.37523160227133 0.0047448216144441 no 62 0.00876897098348373 30 1560353 SGTC_1762 st045503 25.4615 µM 2.37052594343201 0.00481675104455326 no 63 0.00888139864157268 20 4645554 SGTC_1096 rimcazole 32.2 µM 2.36808888514267 0.00485438403522274 no 64 0.00894011983855309 22 18528119 A dopamine reuptake inhibitor. SGTC_965 1291-5240 308 µM 2.33368187885333 0.00541437377558269 no 65 0.00980619282231615 34 2834598 SGTC_2489 cantharidin 73.42 µM 2.33358414916437 0.00541604293855856 no 66 0.00980875368794654 43 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_167 3672-0051 66.205 µM 2.32126449598657 0.00563015353261806 no 67 0.0101362865838016 45 3237971 SGTC_2985 9022375 71.43 µM 2.31816391547101 0.00568521051419668 no 68 0.0102202071624751 38 4939335 SGTC_518 1021-0119 62.6 µM 2.31267791783244 0.00578379724798451 no 69 0.0103701769963155 40 1097762 SGTC_1088 bifonazole 369 nM 2.3011971862223 0.00599503578047704 no 70 0.0106902439374766 21 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1451 4152-0210 104 µM 2.29745321485933 0.00606538652539036 no 71 0.0107964645275781 31 659563 SGTC_922 1866-0035 480 µM 2.29221723053861 0.00616499965466502 no 72 0.0109465555795434 45 3156169 SGTC_2350 9023895 38.85 µM 2.28887429875643 0.0062293534566333 no 73 0.0110433284773963 40 2997209 SGTC_1357 1503-1303 39.5 µM 2.26711603312302 0.00666294301994191 no 74 0.0116915691953655 48 292895 SGTC_2114 5491910 81.25 µM 2.26381729266683 0.0067309567509079 no 75 0.0117926772441246 39 2849228 SGTC_1270 0831-1170 17.3 µM 2.25034986321519 0.00701503637224677 no 76 0.0122133724881869 30 6764716 SGTC_2821 7996764 71.43 µM 2.24906535587039 0.00704267659422277 no 77 0.0122541691441485 37 2987135 SGTC_2302 7771753 200 µM 2.23937919216291 0.0072542181122592 no 78 0.0125656270399483 43 2203047 SGTC_87 0100-0052 35.5 µM 2.23731906334986 0.0072999263132843 no 79 0.0126327470731975 62 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2257 7960413 200 µM 2.23461075860603 0.00736040183333937 no 80 0.0127214569567564 55 2974689 YIL048W NEO1 SGTC_108 0509-0257 621.132 µM 2.22954952744432 0.00747460199548894 no 81 0.0128886819013948 55 536624 SGTC_2045 5106652 78.05 µM 2.21085671873328 0.00791002303343712 no 82 0.0135228803314585 21 673349 SGTC_2300 7976697 71.57 µM 2.20245627827443 0.00811285890771118 no 83 0.0138165471374194 28 2236109 SGTC_1581 himbacine 57.9 µM 2.19548753078248 0.00828457975160598 no 84 0.0140643221921177 34 5281825 An alkaloid muscarinic receptor antagonist. SGTC_958 1222-0007 33 µM 2.19298861958832 0.00834692988448357 no 85 0.0141540995215921 46 7312461 SGTC_2802 7925815 54.55 µM 2.1921737185005 0.00836735131275785 no 86 0.0141834826963082 48 1262923 SGTC_1900 st060200 72.8 µM 2.18955970169657 0.00843315493095785 no 87 0.0142780921496384 44 688945 SGTC_1754 st042065 16.137 µM 2.18004997849005 0.00867639431270877 no 88 0.0146268785286049 72 1126236 YIL048W NEO1 SGTC_3019 9081971 49.47 µM 2.16105867268475 0.00918062634828521 no 89 0.0153454037173065 43 16451803 SGTC_891 0929-0073 133 µM 2.14344612707447 0.0096709902581986 no 90 0.0160386462835027 41 5603632 SGTC_561 1550-0330 72.9 µM 2.13730550364178 0.00984725793419423 no 91 0.0162865757583514 42 6812934 SGTC_1289 0976-0073 69.1 µM 2.13303876078348 0.00997138164320971 no 92 0.0164607733375827 42 3391136 SGTC_2771 fluoxetine 41.05 µM 2.13282351399028 0.00997767941049671 no 93 0.0164696032853602 29 3386 A selective serotonin reuptake inhibitor. SGTC_1253 0550-0034 176 µM 2.12206009749737 0.0102970593656401 no 94 0.0169163458318108 57 5969915 SGTC_1299 1079-1439 3.74 µM 2.11961160943399 0.0103709450863738 no 95 0.0170194063095001 44 323161 SGTC_1932 st074806 40.9 µM 2.11807251023902 0.0104176252373067 no 96 0.0170844636185981 50 17251235 SGTC_660 4031-1742 102 µM 2.11737656131052 0.0104387930976894 no 97 0.0171139509053079 61 6738706 SGTC_3251 9135047 49.47 µM 2.0807934641435 0.0116055813966982 no 98 0.0187264073310351 27 17682963 SGTC_2471 5466956 24.79 µM 2.07169927243979 0.0119126340594167 no 99 0.0191467476217657 76 724419 SGTC_2541 muurolladie-3-one 83.07 µM 2.06235354343769 0.0122354969875863 no 100 0.0195870444097805 85 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2713 st079149 53.4 µM 2.04524700405147 0.0128461421486967 no 101 0.020415256286747 44 3103253 SGTC_2812 7970281 58.44 µM 2.03827519126516 0.0131024725354855 no 102 0.0207612097436826 53 2233435 SGTC_1394 3474-0001 65.7 µM 2.03383867975446 0.0132678798830667 no 103 0.0209839316140532 27 5017666 YIL048W NEO1 SGTC_1695 st026914 34.495 µM 2.02900965018866 0.0134499688429204 no 104 0.0212286537050407 45 3289191 SGTC_3004 9076122 71.4286 µM 2.02212446641714 0.0137133187111533 no 105 0.0215817475051521 49 44782551 SGTC_1475 4092-1048 11.7 µM 2.01011202137827 0.0141834376896419 no 106 0.0222096670119605 55 2881759 SGTC_1194 1488-0194 225 µM 2.00935293689701 0.0142136061252736 no 107 0.0222498587839625 31 1391452 SGTC_718 1130-0073 349 µM 2.00876729076379 0.0142369193297124 no 108 0.022280909317104 51 6740020 SGTC_1271 0832-2808 169 µM 2.00558280933306 0.0143642634240335 no 109 0.0224503887609875 68 3663794 SGTC_3068 9116768 49.47 µM 2.00232459293165 0.0144955700475673 no 110 0.0226249163428077 49 41904888 SGTC_2460 5552655 174.22 µM 1.99417205539322 0.0148286536957588 no 111 0.0230666274589501 64 5401989 SGTC_3199 9111318 49.47 µM 1.98732710213716 0.015113376695728 no 112 0.0234430800870273 45 8548020 SGTC_674 0498-0004 451 µM 1.98597596270874 0.0151701305087653 no 113 0.0235179965055044 81 4231473 SGTC_2075 5212009 200 µM 1.97056356787938 0.0158305832094678 no 114 0.0243869086276787 39 780898 SGTC_1800 st050079 29.0735 µM 1.96465563834683 0.0160902094521361 no 115 0.0247270538271875 82 3645560 SGTC_2456 5770359 74.46 µM 1.95535079869474 0.0165065114769011 no 116 0.0252708395873299 54 3118787 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.95352745822303 0.0165891598734326 no 117 0.0253785634607737 60 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2756 carbadox 75.1 µM 1.9411633520289 0.0171589967243695 no 118 0.0261192333854845 88 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_854 0422-0053 192 µM 1.94017059605017 0.0172054677273587 no 119 0.0261794803578981 57 3596728 SGTC_2407 paclitaxel 400 µM 1.93415665723958 0.0174892856063144 no 120 0.0265469348006612 55 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_900 1112-0045 141 µM 1.92326933860881 0.0180132681206292 no 121 0.0272231165828903 43 56211 YIL048W NEO1 SGTC_3328 9140624 29.0385 µM 1.91116001799491 0.0186117279279746 no 122 0.0279920100972888 57 4904392 SGTC_211 3455-0679 143.504 µM 1.90284734172465 0.0190322801897187 no 123 0.0285302338822727 47 748649 SGTC_2708 st078559 56 µM 1.90195282579823 0.019078013143983 no 124 0.0285886610640174 34 17250902 SGTC_2060 5238662 140 µM 1.88428291396322 0.020000738419986 no 125 0.0297633586525968 46 790130 SGTC_3310 9130229 44.1445 µM 1.88423542169714 0.0200032686058962 no 126 0.0297665691055682 53 7761258 SGTC_3075 9116269 49.47 µM 1.88391145414575 0.0200205354636518 no 127 0.0297884768122661 55 17015205 YNL244C SUI1 SGTC_1846 st056244 14.8 µM 1.88319215701213 0.0200589178452282 no 128 0.0298371657742693 45 5393182 SGTC_1666 st014829 29 µM 1.88290783603048 0.020074106686619 no 129 0.029856429554248 51 3858230 SGTC_2506 ethyl hematommate 54.16 µM 1.86824163357182 0.0208709345522887 no 130 0.030864199014113 41 3940691 An allergen. SGTC_3252 9135871 49.47 µM 1.86773121180957 0.0208991416101134 no 131 0.0308997729141833 56 17682838 SGTC_208 k072-0098 12.366 µM 1.86388397495253 0.0211127885885082 no 132 0.0311689998036612 84 5948901 SGTC_1748 st037455 53.6035 µM 1.85464191851355 0.0216335860302884 no 133 0.0318236889624854 75 580690 SGTC_311 1315-0136 58 µM 1.84761339879783 0.0220368789191932 no 134 0.0323291449933719 52 6759207 SGTC_3151 9099821 49.47 µM 1.84528949711127 0.022171611650985 no 135 0.0324977187447483 73 17174189 SGTC_3190 9110366 49.47 µM 1.84321100430797 0.0222927045995913 no 136 0.0326491044170289 50 17123768 SGTC_756 0508-1999 28.3 µM 1.84055866151064 0.0224480398967443 no 137 0.0328431301708932 72 6753853 SGTC_1906 st060206 94.7 µM 1.83394711674996 0.0228392250973242 no 138 0.0333309222805058 67 5133468 SGTC_255 tunicamycin 200.472 nM 1.82493299892755 0.0233818039110217 no 139 0.0340055703820144 72 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1656 st012921 11 µM 1.82222607537187 0.0235468418731483 no 140 0.0342103448182566 55 6732821 SGTC_3164 9100705 49.47 µM 1.79699502566701 0.0251328083440897 no 141 0.0361682047308551 42 17174235 SGTC_470 aa-861 153 µM 1.79237259015084 0.0254328586379999 no 142 0.0365366512139424 82 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_600 1495-0418 41.6 µM 1.78297917311957 0.0260518504731763 no 143 0.0372948468275379 83 5377768 SGTC_3237 9133362 49.47 µM 1.7797525377665 0.0262673606016747 no 144 0.0375582340929044 64 43845137 SGTC_1047 2043-3044 82 µM 1.76863604772708 0.0270212859583784 no 145 0.0384773155043249 81 669592 SGTC_1724 st037281 8.293 µM 1.76104880964391 0.0275461579051346 no 146 0.0391150710516175 77 574124 YDL195W SEC31 SGTC_2623 humulene 100 µM 1.76089138422613 0.0275571376950405 no 147 0.0391283942324258 47 6187145 An anti-inflammatory. SGTC_650 1328-0195 38 µM 1.75465241270841 0.0279952272532332 no 148 0.0396593902171439 68 2780821 SGTC_1187 1391-0724 117 µM 1.75294814326517 0.0281159016699334 no 149 0.0398054543555417 67 6997986 SGTC_1300 1094-0077 113 µM 1.74966401038168 0.0283496631882359 no 150 0.0400881536706561 68 5532636 SGTC_1938 st074717 56.4 µM 1.73831106060309 0.0291702488359042 no 151 0.0410780092468529 55 17250979 SGTC_575 k072-0246 11.9 µM 1.73438213582062 0.0294587859990752 no 152 0.0414251513042111 72 6796779 SGTC_3058 9093861 49.47 µM 1.7306111873244 0.0297379460660048 no 153 0.0417605675049096 80 17217477 SGTC_558 k064-0027 21.3 µM 1.7276775550129 0.0299566352414373 no 154 0.0420230248786717 88 5088526 SGTC_480 am 92016 50 µM 1.72334870922043 0.0302817660173025 no 155 0.0424127421188564 82 2129 K+ channel blocker. SGTC_998 3996-0085 177 µM 1.71819007964651 0.0306730337350781 no 156 0.0428809752070202 72 715391 SGTC_3178 9107506 49.47 µM 1.71812699640393 0.0306778442115136 no 157 0.0428867268310292 95 8897194 SGTC_3090 9117696 49.47 µM 1.71777950183138 0.0307043539614057 no 158 0.0429184208770282 57 7923821 SGTC_770 0389-1121 67.2 µM 1.7103380885865 0.0312766137520909 no 159 0.0436016861811822 74 6753108 SGTC_1051 3253-3903 78 µM 1.69868891972788 0.0321901502034252 no 160 0.0446889061295983 92 5509239 SGTC_1833 st055984 71 µM 1.6973503178353 0.0322965211460148 no 161 0.0448152247286013 57 676288 SGTC_222 nsc-310342 10.666 µM 1.69117761408489 0.0327907896828031 no 162 0.0454014425757528 54 432556 SGTC_503 tyrphostin 8 294 µM 1.68926021585819 0.0329455854793108 no 163 0.0455847869510731 83 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3313 9133968 57.047 µM 1.68549889771395 0.0332509945907477 no 164 0.0459461786528635 59 1494643 SGTC_2687 chenodiol 100 µM 1.68357739857449 0.0334079129156153 no 165 0.0461316848567059 82 5702181 A cholesterol synthesis inhibitor. SGTC_29 0299-0004 12.984 µM 1.68178700336237 0.0335546729623534 no 166 0.0463050749065515 48 16871 A napthoquinone isolated from Swertia calycina. SGTC_456 gingerol 170 µM 1.68056661882718 0.0336550126333701 no 167 0.0464235621288308 70 442793 A herb. SGTC_865 0488-0499 301 µM 1.67777951944835 0.0338850932686887 no 168 0.0466950744832165 67 9634651 SGTC_236 1509-0011 5.31 µM 1.67536074635864 0.0340858150550089 no 169 0.0469317367063811 121 3107280 SGTC_673 1082-0474 110 µM 1.67454835218074 0.03415345048105 no 170 0.0470114399918996 135 3098046 SGTC_1282 0886-0010 32.4 µM 1.67448031739769 0.0341591196825927 no 171 0.0470181197476887 100 2836211 YNL267W PIK1 SGTC_1339 1486-1321 22.7 µM 1.67325054199056 0.0342617278398922 no 172 0.0471389921759873 84 3469382 SGTC_2646 retinol 96.75 µM 1.67286141811683 0.0342942476882322 no 173 0.0471772903054663 84 445354 A vitamin A analog and teratogen. SGTC_116 0155-0182 31.788 µM 1.6714229297569 0.0344146852989213 no 174 0.0473190849701675 71 771486 SGTC_1930 st074634 34.3 µM 1.67036235410248 0.034503704525363 no 175 0.0474238465971673 92 684253 YOR116C RPO31 SGTC_2063 5246145 200 µM 1.66855302876448 0.0346560065127101 no 176 0.0476029971504557 91 711240 SGTC_2717 st081029 62.2815 µM 1.66764115940856 0.0347329731375931 no 177 0.0476934912183677 66 5292846 SGTC_1383 3049-0032 20.7 µM 1.66310884883257 0.0351176095586831 no 178 0.0481453244620791 92 712864 SGTC_2184 6075246 200 µM 1.66269097960507 0.0351532474933884 no 179 0.0481871543852174 61 2267320 SGTC_1409 3909-8004 61.9 µM 1.65356908057968 0.0359386299356464 no 180 0.0491075496574445 80 2119279 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.65113842754703 0.0361503138944088 no 181 0.0493551561262252 73 3256 An antibiotic and ribosome inhibitor. SGTC_2362 9071156 126 µM 1.64577653560053 0.0366208886178007 no 182 0.0499048874500301 79 653133 SGTC_1671 st016596 74.5 µM 1.6409824982598 0.0370458588027952 no 183 0.0504005241413194 81 2829167 SGTC_704 1310-0270 142 µM 1.64039654831181 0.0370980760117515 no 184 0.0504613712807428 68 5718033 SGTC_8 0354-0001 70 µM 1.63829615446298 0.0372857480940282 no 185 0.0506799647500621 97 4993152 SGTC_3240 9133527 49.47 µM 1.63237821471629 0.0378186959832616 no 186 0.0512999177743832 67 17617455 SGTC_3001 9076041 71.4286 µM 1.63212202683301 0.0378419069923111 no 187 0.0513268912051905 69 16004211 SGTC_2829 7992743 58.44 µM 1.6286572719572 0.0381569623144006 no 188 0.0516927963958664 66 16462845 SGTC_166 k072-0058 166.424 µM 1.62822144602884 0.0381967436505037 no 189 0.0517389694795315 93 5846229 SGTC_2449 5812982 45.77 µM 1.62406782067944 0.0385775781317209 no 190 0.05218066742828 57 776185 SGTC_1365 1672-3266 55.4 µM 1.61339432032201 0.0395704080193414 no 191 0.0533294331564566 96 6415873 SGTC_683 panaxydol 45 µM 1.59406149559795 0.0414215685098507 no 192 0.0554611309728696 56 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1513 0337-0559 19 µM 1.58830016080304 0.0419866061231615 no 193 0.0561092405829875 78 775073 SGTC_2707 st078556 66.6 µM 1.58609466375689 0.0422045529445692 no 194 0.0563589185965902 66 17250899 SGTC_874 0599-0792 117 µM 1.58123970404338 0.0426875451902257 no 195 0.0569116201425206 107 765305 SGTC_1354 1498-1681 81 µM 1.57896747092391 0.0429151267864174 no 196 0.0571717592443979 95 5754243 SGTC_847 0342-0274 5.54 µM 1.57576681591926 0.0432373591184561 no 197 0.0575397763082264 104 18097 SGTC_3073 9114972 49.47 µM 1.57352732298737 0.0434639843010457 no 198 0.0577983833842655 73 41905075 SGTC_1472 k841-0093 193 µM 1.56559124018788 0.0442748050707791 no 199 0.0587221710261953 74 X1472 SGTC_2010 4012422 159 µM 1.56441936038502 0.0443955611935502 no 200 0.0588595584934913 92 952393 SGTC_2123 5259487 200 µM 1.56227150737213 0.0446175751713779 no 201 0.05911202063304 86 2173474 SGTC_989 1501-0895 10.3 µM 1.55910850110537 0.0449461482595801 no 202 0.0594853509608986 77 2830112 SGTC_975 1335-0046 28.5 µM 1.55791048627546 0.045071105484653 no 203 0.0596272345304839 75 16486740 SGTC_1798 st045719 60.953 µM 1.55634095135854 0.0452352364936556 no 204 0.0598135191998388 87 3980186 SGTC_1466 k213-0079 57.5 µM 1.55552155985103 0.0453211135967041 no 205 0.0599109519571266 120 3657981 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.55388813827578 0.045492697167492 no 206 0.0601055508071158 99 688801 SGTC_2023 5144124 124 µM 1.55301835266352 0.0455842771411553 no 207 0.0602093750790439 90 2830192 SGTC_3132 9126706 49.47 µM 1.55118577117012 0.0457777153067546 no 208 0.0604285855148602 105 850858 SGTC_689 0833-0039 98 µM 1.54844163438774 0.0460686057243107 no 209 0.0607580018757971 80 5374726 SGTC_45 0kpi-0036 14.9 µM 1.54514941141162 0.0464195528963572 no 210 0.0611550637778483 76 2795021 SGTC_1189 1431-2119 7.28 µM 1.54100532721484 0.0468643548865531 no 211 0.061657744726881 107 3107275 SGTC_2648 atorvastatin 78.68 µM 1.53936767908696 0.0470410702434458 no 212 0.0618572799566533 84 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2608 thymoquinone 42.66 µM 1.53657020108681 0.0473441760712487 no 213 0.0621992972351523 83 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1184 1269-1718 139 µM 1.52944965037957 0.0481227501563269 no 214 0.063076505949505 93 5403821 SGTC_1734 st037168 69.4 µM 1.52203247204482 0.0489446182164611 no 215 0.0640004722533022 97 708907 SGTC_632 0781-2353 4.65 µM 1.52137791905947 0.0490176819027791 no 216 0.0640825133808286 131 6811515 YHR007C ERG11 SGTC_746 1095-0025 46.6 µM 1.51834094125284 0.0493578215807118 no 217 0.0644642358346516 94 6749286 SGTC_3018 9082602 49.47 µM 1.51498155713447 0.0497362628271683 no 218 0.0648885373585923 106 17332089 SGTC_961 1252-1571 372 µM 1.51406994096084 0.0498393565279939 no 219 0.0650040507456582 108 6813498 SGTC_19 0279-0214 38.434 µM 1.5035445114314 0.0510420516008864 no 220 0.066349343869595 101 3566274 YBR002C RER2 SGTC_2243 6634756 200 µM 1.50203352548073 0.0512165857632202 no 221 0.066544225399249 64 885676 SGTC_2908 7930301 100 µM 1.49592775083773 0.0519267056976476 no 222 0.0673362418732387 97 2223178 SGTC_1751 st044839 27.194 µM 1.49395909923184 0.0521573264264581 no 223 0.0675931549660767 85 5291326 SGTC_538 2922-0838 53.3 µM 1.48843295921169 0.0528090433581194 no 224 0.0683183749744323 117 777039 SGTC_3117 9124945 49.47 µM 1.48732541215314 0.0529404341215551 no 225 0.0684644429771119 80 17592065 SGTC_18 0111-0177 500 nM 1.48677260641702 0.053006111625927 no 226 0.0685374394229705 106 721752 SGTC_2970 9090938 41.86 µM 1.48285238010444 0.0534737198559312 no 227 0.0690568178853588 105 17217104 SGTC_2034 5197015 53.07 µM 1.47932713522616 0.0538970000558513 no 228 0.0695264519622116 102 780676 SGTC_1198 1612-1005 86.7 µM 1.47509560488044 0.0544085832012145 no 229 0.070093420959277 117 6998509 SGTC_2479 5617353 43.85 µM 1.46928126032856 0.0551177814233634 no 230 0.0708782587515462 121 2731746 SGTC_1860 st056228 74.6 µM 1.46856446363655 0.0552057152635738 no 231 0.0709754797334186 122 688679 SGTC_458 nppb 133 µM 1.46415729746523 0.0557488068595539 no 232 0.0715754874115413 81 4549 A chloride channel blocker. SGTC_3345 9148410 3.559 µM 1.45619948445869 0.0567401122617104 no 233 0.0726687410085252 93 4903596 SGTC_3126 9127922 49.47 µM 1.45554302763491 0.0568225031763314 no 234 0.0727594936748867 151 45595682 SGTC_2198 6589944 200 µM 1.45495898731554 0.0568958843837324 no 235 0.0728403079608006 94 5290268 SGTC_1368 1852-0141 284 µM 1.4516189581184 0.0573169739553756 no 236 0.0733037922053957 105 2838987 SGTC_899 1083-0020 478 µM 1.44988948043259 0.0575359770836322 no 237 0.0735446706503065 104 767123 SGTC_2050 5263056 171 µM 1.44974628701227 0.0575541390779999 no 238 0.0735646414626696 122 763468 YGL055W OLE1 SGTC_1706 st031321 9.9705 µM 1.44925470153077 0.0576165238325957 no 239 0.0736332331588547 104 6103185 SGTC_3116 9124943 49.47 µM 1.44877971233686 0.0576768529381073 no 240 0.0736995555853768 98 41905195 YPL160W CDC60 SGTC_1238 0333-0287 48.8 µM 1.44707363680958 0.0578939539299701 no 241 0.0739381503985731 94 7226 SGTC_2763 lisinopril 49.32 µM 1.44669961427713 0.0579416346697848 no 242 0.0739905362771578 93 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3244 9134489 49.47 µM 1.44311000664597 0.0584008122420495 no 243 0.0744947424591718 113 16584271 SGTC_1638 st008370 60.6 µM 1.44141561083448 0.0586185475144668 no 244 0.0747336513081456 113 24207134 SGTC_634 1611-4317 11.2 µM 1.43990396866235 0.0588133357848266 no 245 0.074947285063307 117 2843522 SGTC_1476 4112-3294 3.34 µM 1.43984313964738 0.0588211847524352 no 246 0.0749558915005165 102 704369 SGTC_1820 st053765 18.6 µM 1.43359917746995 0.0596312456148012 no 247 0.0758433391880207 95 3690829 SGTC_2909 7941780 10.49 µM 1.43153887530032 0.0599004488715689 no 248 0.0761379168218102 114 1243215 SGTC_759 3486-0358 89.3 µM 1.42755021835949 0.060424319188887 no 249 0.0767106804983706 115 875103 SGTC_374 0880-0231 82.3 µM 1.42476688603791 0.06079200103947 no 250 0.077112298687178 116 6833587 SGTC_618 k072-0232 33.2 µM 1.42244026993482 0.0611006906268442 no 251 0.0774492398416787 121 5872756 YGL099W LSG1 SGTC_941 3237-0776 460 µM 1.42174545427888 0.0611931141932052 no 252 0.0775500797305461 95 760008 SGTC_104 0074-0074 590.992 µM 1.41653173483499 0.0618901266823815 no 253 0.0783099397449595 112 3943124 SGTC_2070 5230947 200 µM 1.41593347651747 0.0619705014485514 no 254 0.0783974912032171 108 2835538 SGTC_464 bw-b 70c 158 µM 1.4105265989084 0.0627006036881493 no 255 0.0791921240382425 116 5353454 SGTC_1416 3966-0321 25.3 µM 1.41010143594587 0.0627582974562376 no 256 0.0792548666730195 113 582530 YLR208W SEC13 SGTC_441 propafenone 146 µM 1.40828932740516 0.063004661009862 no 257 0.0795227073127214 117 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3316 9136639 10.545 µM 1.40723509027887 0.0631483350853006 no 258 0.0796788448042821 109 4903665 SGTC_1019 4262-0212 3.4 µM 1.40615859726636 0.0632953053924141 no 259 0.0798385177022257 122 4677213 SGTC_3266 9136860 49.47 µM 1.40580630950905 0.063343459956529 no 260 0.0798908239841016 126 4871271 YPR165W RHO1 SGTC_265 mycophenolic acid 32.932 µM 1.40544243600565 0.0633932281249035 no 261 0.0799448776746833 97 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3205 9113483 49.47 µM 1.40527631085382 0.0634159597225826 no 262 0.0799695648876191 101 17018033 SGTC_663 1486-0733 13.9 µM 1.40491675457519 0.0634651810346433 no 263 0.080023016887399 111 722445 YPR165W RHO1 SGTC_1255 0566-0045 221 µM 1.39866573069805 0.0643256726164652 no 264 0.0809566226409037 117 2788469 SGTC_2083 5306046 65.942 µM 1.3886056070325 0.0657295126028327 no 265 0.0824763557125186 110 539837 SGTC_2339 9000433 200 µM 1.38846711501023 0.0657490028837774 no 266 0.0824974258673795 97 2988954 SGTC_2227 7312221 64.1025 µM 1.37968836222444 0.0669936218118439 no 267 0.0838413088336588 112 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_925 2064-1272 59.6 µM 1.37518075261741 0.067639735414303 no 268 0.0845377069603211 122 6815817 SGTC_3148 9097893 49.47 µM 1.3730350880703 0.0679489779146513 no 269 0.0848707194328596 104 17174100 SGTC_3283 9109332 35.8195 µM 1.37027740481992 0.0683480290594861 no 270 0.0853001617890852 90 17027281 SGTC_2690 usnic acid 100 µM 1.36412423794249 0.0692449412919286 no 271 0.0862642337718662 112 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2666 tannic acid 100 µM 1.36335904499762 0.0693571101554787 no 272 0.0863846908959616 137 16134267 A thiamine antagonist. SGTC_2148 5546263 113.568 µM 1.36230415186129 0.0695119752823683 no 273 0.0865509589504236 112 792097 SGTC_1249 0481-0015 10.2 µM 1.36194361729809 0.0695649650971296 no 274 0.0866078397908496 128 4227577 SGTC_710 3448-4187 58 µM 1.36103809396113 0.0696981921715693 no 275 0.0867508256688915 121 3946412 SGTC_1878 temozolomide 1 mM 1.36018084850416 0.0698244971629066 no 276 0.0868863507492444 109 5394 DNA alkylating agent. SGTC_2785 7756463 72.73 µM 1.35817255182067 0.0701210856599816 no 277 0.0872044690023294 157 2201551 SGTC_795 0685-0265 78 µM 1.3579587840014 0.0701527122163147 no 278 0.0872383814033256 140 302754 SGTC_2174 5790901 200 µM 1.35584645346508 0.0704658177876697 no 279 0.0875740137657018 125 786020 SGTC_2396 5342950 42.78 µM 1.35425014437171 0.0707031466330686 no 280 0.087828293006446 170 1886677 SGTC_595 3909-8003 73.7 µM 1.35183654269422 0.0710631510602845 no 281 0.0882138056177274 116 699517 SGTC_1398 3558-0053 112 µM 1.35043726705594 0.0712725058316313 no 282 0.0884378817895352 89 4532369 SGTC_505 gw-5074 63.9 µM 1.34695391727198 0.0717957288286634 no 283 0.0889975374329251 113 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1564 D-Arginine 115 µM 1.34611607707011 0.071922016603242 no 284 0.0891325422734692 146 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1720 st037298 9.481 µM 1.34521566088305 0.0720579262877685 no 285 0.0892778000982243 121 597396 SGTC_3321 9137793 26.8275 µM 1.33911784352242 0.0729835237556004 no 286 0.0902661562294103 143 4904192 SGTC_491 tetrandrine 80.3 µM 1.33379540813609 0.0737988387797653 no 287 0.0911354581463987 113 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_665 3914-0008 307 µM 1.33157378107189 0.0741412099066638 no 288 0.0915001426588113 113 1069549 SGTC_751 0833-0568 350 µM 1.33099328957315 0.0742308680664045 no 289 0.0915956094745802 118 6954252 SGTC_2032 5185112 25.99 µM 1.32699565171529 0.0748505619855305 no 290 0.0922550605306032 101 5718189 SGTC_3049 9092223 49.47 µM 1.32482357616371 0.075188917019981 no 291 0.0926148366431623 102 8623917 SGTC_1169 aniline yellow 25.8 µM 1.32262171347498 0.0755331011504713 no 292 0.0929806048274116 120 6051 A DNA damaging agent. SGTC_1984 st072354 53.1 µM 1.31945126675286 0.0760307966138289 no 293 0.0935091460774986 118 5762938 SGTC_959 1222-0044 107 µM 1.31805020405224 0.0762515287005868 no 294 0.093743421179806 121 6083612 SGTC_1480 1070-0044 41.2 µM 1.31769207413989 0.0763080288901815 no 295 0.0938033744306142 116 3124987 SGTC_2351 9026858 72.31 µM 1.31470565288522 0.0767804213200101 no 296 0.0943044230091515 139 1409300 SGTC_2375 9072683 200 µM 1.31393495408896 0.0769026907440974 no 297 0.094434047298688 125 16798029 SGTC_716 1683-5115 658 µM 1.31341395980947 0.0769854289858955 no 298 0.0945217480308129 135 723597 SGTC_2358 9037157 4 µM 1.3125333568208 0.0771254298952494 no 299 0.0946701194121039 135 2388925 SGTC_2346 9031566 143.75 µM 1.31155175486388 0.0772817158510131 no 300 0.0948357101895387 111 4771086 SGTC_826 1683-5028 118 µM 1.31124398820736 0.0773307664906408 no 301 0.0948876726304813 107 722377 SGTC_2584 androsterone 48.74 µM 1.3107005692607 0.0774174322024178 no 302 0.0949794731430465 141 2754130 A steroid. SGTC_1261 0712-0010 12.7 µM 1.30756659502322 0.0779186857438386 no 303 0.0955101767007079 123 2840123 SGTC_2576 guaiol 23.12 µM 1.30695170749199 0.0780173203341008 no 304 0.0956145566508681 127 227829 SGTC_511 blebbistatin 171 µM 1.30405622344265 0.0784830609046374 no 305 0.0961072066538336 114 3476986 A myosin inhibitor. SGTC_1448 4255-0083 152 µM 1.29900799135593 0.079300108918724 no 306 0.0969705933458611 148 5399660 SGTC_1579 chlormadinone acetate 49.4 µM 1.29224406029512 0.0804049125049281 no 307 0.0981363187992572 128 45114258 A steroidal progestin. SGTC_2595 hexamethylquercetagetin 100 µM 1.29192133378626 0.0804579150686755 no 308 0.0981921944033539 141 386331 SGTC_2491 paeonol 100 µM 1.29024833706731 0.0807331006553876 no 309 0.0984822240820993 110 11092 Increases levels of cortical cytochrome oxidase. SGTC_839 0122-0028 230 µM 1.28756973853531 0.0811751733579315 no 310 0.0989478895105329 185 759448 SGTC_2911 7942208 15.64 µM 1.28570359904021 0.0814842366489818 no 311 0.0992732623548282 103 1243384 SGTC_3309 9129340 25.759 µM 1.2824000336245 0.0820335359725313 no 312 0.0998511762119943 115 17158987 SGTC_2321 7390090 138.78 µM 1.27096576315572 0.0839563123179182 no 313 0.101870414417159 106 649046 SGTC_771 0250-0039 27.3 µM 1.26483328889105 0.0850013875867263 no 314 0.10296554774384 146 3005115 SGTC_2210 7115885 190.385 µM 1.26470650398951 0.0850230962514219 no 315 0.102988278797303 123 2927039 SGTC_1470 k295-0292 231 µM 1.26323067233713 0.0852761003943388 no 316 0.103253146420774 143 5045612 SGTC_88 0180-0332 8.668 µM 1.26299826465623 0.0853159937609566 no 317 0.103294901682078 137 3101745 SGTC_1066 ketoconazole 628 nM 1.26162502683863 0.0855519989176317 no 318 0.103541873138498 137 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1092 toremifene 6.32 µM 1.2608248549428 0.0856897419929056 no 319 0.103685978380686 138 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1360 1598-0022 39.8 µM 1.26013373721081 0.0858088458564158 no 320 0.103810560817392 152 761525 SGTC_120 rhodamine 6G 52.259 µM 1.25688920169897 0.0863696500550802 no 321 0.104396879602032 185 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_257 daunorubicin 18.5 µM 1.25586248476175 0.0865476833538507 no 322 0.104582916106197 127 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1334 1486-0610 236 µM 1.25505241939585 0.0866883426451759 no 323 0.104729865713217 143 3742339 SGTC_2279 7948423 32.93 µM 1.24701991135721 0.0880923606469303 no 324 0.106195098392342 121 1247112 SGTC_757 1066-0008 322 µM 1.24436224589263 0.0885606120492317 no 325 0.106683135707793 140 6842497 SGTC_748 act1.228 77.9 µM 1.24256182745753 0.0888788778186682 no 326 0.107014671907389 120 4421505 YNR035C ARC35 SGTC_2781 5567276 71.43 µM 1.23484464130701 0.0902527212079392 no 327 0.108444164785563 146 2853274 SGTC_1089 terbinafine 2.25 µM 1.23351061057297 0.090491800971311 no 328 0.108692660242799 125 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2103 5378138 10 µM 1.23272503715587 0.0906328081571049 no 329 0.108839183712032 134 244142 SGTC_227 fluconazole 33.516 µM 1.22818704863692 0.0914505518521886 no 330 0.109688379700958 185 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_626 0214-0009 33 µM 1.22654554680876 0.0917476927124544 no 331 0.109996723182038 146 3437874 SGTC_910 3454-3003 490 µM 1.22437609239477 0.0921414988171156 no 332 0.110405191946666 170 820824 SGTC_1029 k015-0030 64.7 µM 1.22335874945817 0.0923266004802932 no 333 0.110597113228901 149 2208316 SGTC_625 k213-0058 121 µM 1.22027995314989 0.0928884521664262 no 334 0.111179383305027 173 3655420 SGTC_3338 9144300 39.5675 µM 1.21380526329903 0.094078263694216 no 335 0.112411047992918 113 4901274 SGTC_2808 7946468 45.46 µM 1.21312545193288 0.0942038375423089 no 336 0.112540930174733 162 2970879 SGTC_597 k018-0003 82.8 µM 1.21278282689261 0.0942671736238879 no 337 0.112606431427529 142 6786234 SGTC_658 3253-0951 102 µM 1.20935550114937 0.0949024624762837 no 338 0.113263148312396 156 1184878 SGTC_415 dibenzyl ketone 100 µM 1.20848729569707 0.0950638925669836 no 339 0.113429939789206 149 7593 SGTC_2953 9074162 66.49 µM 1.20729724738815 0.095285493110852 no 340 0.113658845186299 131 16451992 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.20655800483515 0.0954233398642297 no 341 0.113801203955485 147 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1948 st076329 66.6 µM 1.20504821235053 0.0957053272076064 no 342 0.114092345173439 130 24208413 SGTC_717 1532-0246 73.2 µM 1.2021033253192 0.0962571137019622 no 343 0.114661749087655 142 9561992 SGTC_2863 9028737 58.44 µM 1.20145021051298 0.096379804669812 no 344 0.11478830455664 126 6460917 SGTC_914 3820-6779 408 µM 1.20124941705536 0.0964175478381913 no 345 0.114827232704555 118 2893481 SGTC_1213 1315-0166 115 µM 1.20112877703968 0.0964402297776666 no 346 0.114850625892765 144 768401 SGTC_2669 eugenol 100 µM 1.2009795162884 0.0964682982249324 no 347 0.114879573591813 96 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1508 1080-0625 72.9 µM 1.19875693269917 0.0968869648888994 no 348 0.115311236619928 137 767111 SGTC_3269 9137823 49.47 µM 1.19841183794874 0.0969520896362174 no 349 0.115378363074543 112 17682936 SGTC_312 4092-0653 6.84 µM 1.19433554724874 0.0977237821663646 no 350 0.116173368922826 171 1148278 SGTC_369 0957-0393 4.5 µM 1.18856131799346 0.0988246092655842 no 351 0.117306168591034 142 6997992 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.18583817221837 0.0993469004229643 no 352 0.117843106789855 128 6710655 SGTC_2976 9009005 19.48 µM 1.17758010673686 0.100943106501066 no 353 0.119482022228203 122 2993148 SGTC_1188 1403-0014 4.57 µM 1.17652005806896 0.10114935034518 no 354 0.119693560965285 140 9614867 SGTC_2109 5483026 200 µM 1.1757385926742 0.101301589348119 no 355 0.119849675861428 199 759335 SGTC_422 cantharidin 155 µM 1.17500853650853 0.101443963971099 no 356 0.119995650286782 146 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_578 3460-0051 92 µM 1.17398581156467 0.10164365951422 no 357 0.120200354389518 180 2876744 SGTC_2066 5222451 176 µM 1.17363232423786 0.101712747371867 no 358 0.120271164035839 171 2281147 SGTC_2667 digitoxin 100 µM 1.17358313600855 0.101722363747751 no 359 0.120281019620527 107 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.16984543081113 0.102455028329782 no 360 0.121031588647436 154 1377 SGTC_1972 st070201 17.4 µM 1.16903587258 0.102614222131467 no 361 0.121194589342197 143 2829099 SGTC_586 0957-0265 8.15 µM 1.16665308699437 0.103083823047044 no 362 0.121675247672064 155 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1799 st045822 46.1415 µM 1.16400251597217 0.103608030937596 no 363 0.122211496081945 154 3674992 SGTC_1006 4099-6547 255 µM 1.16329702354254 0.103747882748152 no 364 0.122354506448573 153 3146833 SGTC_2215 7188065 200 µM 1.16261437411474 0.103883336643603 no 365 0.122492998085396 144 940217 SGTC_1302 1159-0335 255 µM 1.15861326168755 0.104679832186407 no 366 0.123306930382422 135 649284 SGTC_82 0054-0107 293.755 µM 1.15783218400321 0.104835834803686 no 367 0.123466263350319 143 3104697 SGTC_2986 9022445 71.43 µM 1.15639661332906 0.105122996495448 no 368 0.123759483110189 165 6459286 SGTC_1493 4348-0038 111 µM 1.15627274692793 0.105147800530785 no 369 0.123784806034769 185 800424 SGTC_1763 st044482 94.5 µM 1.15608377912673 0.105185649169253 no 370 0.123823445107672 164 88505 SGTC_1320 1313-0481 95.3 µM 1.15493560621371 0.105415830352274 no 371 0.124058398542987 124 6813365 YLR208W SEC13 SGTC_49 0717-0965 32.132 µM 1.15315702337319 0.105773112621976 no 372 0.124422969875296 144 5889349 YGL099W LSG1 SGTC_1125 tnp00248 1.32998 µM 1.1529408806443 0.105816591021379 no 373 0.124467325498663 172 24207736 SGTC_1784 st039334 36.3 µM 1.15104809581067 0.106197887967768 no 374 0.124856224761517 165 3496984 SGTC_1660 st012960 28.1 µM 1.15041499412076 0.106325646009866 no 375 0.124986493688751 138 24207266 SGTC_1991 st073000 8.92 µM 1.14649080894249 0.107120011618737 no 376 0.125796064017585 164 4301969 YIL048W NEO1 SGTC_202 3594-0513 34.79 µM 1.14574029592641 0.107272422886475 no 377 0.125951312669666 145 708429 SGTC_1574 spiramycin 23.7 µM 1.14490652677848 0.107441924738394 no 378 0.126123940011994 165 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2442 5158906 48.48 µM 1.14365477942516 0.107696762171639 no 379 0.126383417025123 156 1893835 SGTC_105 0111-0055 734.78 µM 1.14341200408354 0.107746238053846 no 380 0.12643378540799 129 5179370 SGTC_793 0488-0545 106 µM 1.14000253666693 0.108442793440483 no 381 0.12714262215608 154 292548 SGTC_1949 st076024 69.1 µM 1.13836873580028 0.108777725399816 no 382 0.127483271605981 180 2921930 SGTC_181 1447-1644 8.07 µM 1.13836788402997 0.108777900207963 no 383 0.127483449366486 173 534600 SGTC_1690 st023502 41.2 µM 1.13451942467601 0.109569779967345 no 384 0.128288365215296 162 24207482 SGTC_3281 9140613 49.47 µM 1.13448022699401 0.109577866733211 no 385 0.128296581631688 136 16013766 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.1331027233951 0.109862327923951 no 386 0.128585558917268 181 5393153 SGTC_3270 9137563 49.47 µM 1.12990056907041 0.11052563537273 no 387 0.12925906207715 142 17015724 SGTC_2592 piperlongumine 83.33 µM 1.1289249347151 0.110728301726382 no 388 0.12946475055401 170 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2249 haloperidol 116.36 µM 1.12781040108226 0.110960147022998 no 389 0.129699999903632 189 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_9 0092-0002 10.449 µM 1.12622580545316 0.111290372933531 no 390 0.130034976652376 173 759368 SGTC_2516 gossypol 71.55 µM 1.12492945266459 0.111561052488335 no 391 0.130309465062761 155 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1847 st056231 15 µM 1.12451724204085 0.111647221042227 no 392 0.130396830050636 155 5393180 SGTC_2052 5265182 7.135 µM 1.12128849675351 0.112323805758771 no 393 0.131082540215256 157 1239884 SGTC_1931 st074438 57.1 µM 1.12020625531182 0.112551244109127 no 394 0.131312939475313 199 2787313 SGTC_495 decylubiquinone 155 µM 1.11876554897545 0.112854525768876 no 395 0.131620086312364 148 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_892 0929-0076 29 µM 1.11801077306078 0.113013645580953 no 396 0.131781196147278 148 5751038 SGTC_2606 farnesol 9.78 µM 1.11579684452961 0.113481303454934 no 397 0.132254552404083 176 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_416 estradiol valerate 100 µM 1.11056738363215 0.114591420883431 no 398 0.133377304302283 172 13791 A steroid. SGTC_581 0958-0271 211 µM 1.10928245713634 0.114865365771125 no 399 0.133654175279733 131 4591145 SGTC_2439 5492030 7.2 µM 1.10875595683284 0.11497774949046 no 400 0.133767737578793 158 5722370 SGTC_1231 0242-0792 125 µM 1.10822208281417 0.115091786989645 no 401 0.133882958046901 152 3707635 SGTC_3060 1327-0027 12.5 µM 1.10794045108944 0.11515197697868 no 402 0.133943767162006 158 16000455 YPR107C YTH1 SGTC_2685 mycophenolic acid 18.85 µM 1.10649677510518 0.115460869057354 no 403 0.134255779541368 146 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_709 3807-1509 243 µM 1.10527865360484 0.115721958629206 no 404 0.134519432281626 181 1886677 YPL242C IQG1 SGTC_391 gliotoxin 8.33 µM 1.10316874562555 0.116175183494522 no 405 0.134976945662404 160 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2262 9014885 67.46 µM 1.1023811555461 0.116344686513379 no 406 0.135148000283535 149 6457424 SGTC_1164 k060-0068 93.7 µM 1.10041660549664 0.11676825616849 no 407 0.135575323327175 156 5963676 SGTC_824 1304-0008 100 µM 1.09971338656306 0.116920140081336 no 408 0.135728510150543 158 768245 SGTC_2443 5493264 126.67 µM 1.09895330058502 0.117084463759466 no 409 0.135894217972284 161 5340055 SGTC_1569 carminic acid 40.6 µM 1.09837606647844 0.117209365799781 no 410 0.136020154413027 151 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_275 trichlorophene 5.69 µM 1.09611124923892 0.117700339023899 no 411 0.136515046154093 152 62616 SGTC_1039 k821-0043 94 µM 1.09324585844071 0.118323589566712 no 412 0.137142933641749 141 15992768 SGTC_583 1488-1091 88.9 µM 1.09254960254962 0.118475383744493 no 413 0.137295800295678 197 4303273 SGTC_742 0kpi-0133 140 µM 1.0916650663424 0.118668424264588 no 414 0.137490172656701 165 2728852 SGTC_1703 st026983 48.3 µM 1.09097626293522 0.118818902034649 no 415 0.137641663771294 154 1104023 SGTC_676 falcarinol 140 µM 1.09065601746857 0.118888909565345 no 416 0.137712135338524 177 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3119 9125183 49.47 µM 1.08297088304413 0.120577668963316 no 417 0.139410673614308 128 22695334 SGTC_223 busulfan 5 mM 1.08201509152824 0.120788873155781 no 418 0.139622911075806 139 2478 A DNA alkylator. SGTC_357 1325-0123 420 µM 1.07863319696045 0.121538270956772 no 419 0.140375638196471 170 1098503 SGTC_1269 0831-0796 3.05 µM 1.07667473832841 0.12197373927303 no 420 0.140812800917973 174 927758 SGTC_2295 7971645 200 µM 1.07503910815149 0.122338264716132 no 421 0.141178609743785 152 2978226 YKL099C UTP11 SGTC_601 0986-0029 62.9 µM 1.07456768148349 0.122443471238971 no 422 0.141284163869392 169 24747981 SGTC_2141 5621638 7.665 µM 1.07378909119738 0.122617365304435 no 423 0.141458610146532 163 2856238 SGTC_194 1486-1323 56.904 µM 1.07237582171729 0.122933454154454 no 424 0.141775631641668 182 5178754 SGTC_253 dyclonine 31.25 µM 1.06619047344517 0.124323576167932 no 425 0.143168773859043 154 3180 An oral anasthetic. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.06490926972556 0.124612888545495 no 426 0.143458494900086 190 1273210 SGTC_1913 st060213 96.1 µM 1.06480962158303 0.124635410094175 no 427 0.143481045102765 180 688959 SGTC_1388 3346-4487 254 µM 1.06404473412619 0.124808377597967 no 428 0.143654217492242 177 3345614 SGTC_191 3914-0123 66.505 µM 1.06383046263634 0.124856861852505 no 429 0.143702754362254 172 3144412 SGTC_3263 9137018 49.47 µM 1.06373769392192 0.124877857163375 no 430 0.143723771803702 186 43844957 SGTC_649 1123-0311 367 µM 1.06312279163148 0.125017083517924 no 431 0.143863134924422 182 693629 YIL048W NEO1 SGTC_1035 k081-0041 55.2 µM 1.06215805688641 0.125235737471054 no 432 0.144081968677712 180 731709 SGTC_2565 isoliquiritigenin 100 µM 1.05920652650213 0.125906349689737 no 433 0.144752866695079 169 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_406 estrone 100 µM 1.05897153166882 0.125959849894548 no 434 0.144806372503108 167 5870 A steroid. SGTC_1191 1487-1166 10.6 µM 1.05771859947083 0.126245366840571 no 435 0.145091876542487 161 3955771 SGTC_147 4466-0538 29.23 µM 1.05714400177793 0.12637645633953 no 436 0.145222936003626 174 6742687 YHR072W ERG7 SGTC_1868 st057644 42.7 µM 1.05691880126049 0.126427859753555 no 437 0.145274323504494 158 688665 SGTC_2543 pimpinellin 60.67 µM 1.05440870486849 0.127001790967607 no 438 0.145847919295638 168 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2466 5983409 37.09 µM 1.05329198182117 0.127257710605746 no 439 0.146103596320024 159 2879657 SGTC_1351 1496-0003 46.5 µM 1.05212924135386 0.127524557068859 no 440 0.14637012893711 177 3891978 SGTC_2919 7978188 46.38 µM 1.05201064150739 0.127551797331808 no 441 0.146397333673171 165 2980291 SGTC_1167 k781-0610 148 µM 1.05003901797233 0.12800523672549 no 442 0.146850087024627 179 4525169 SGTC_2545 solidagenone 89.61 µM 1.04823469998716 0.128421178998891 no 443 0.147265243441702 128 6708572 An anti ulcer agent SGTC_2348 9022543 33.42 µM 1.04796175113912 0.128484182425223 no 444 0.147328114814 203 3162678 YDL140C RPO21 SGTC_2894 9048625 32.47 µM 1.04670468901099 0.128774620751318 no 445 0.147617900219876 186 4092861 SGTC_1211 1056-0033 32.3 µM 1.04501347686681 0.129166085531719 no 446 0.148008370423486 177 6741922 SGTC_2483 5729050 27.16 µM 1.04329062597892 0.12956572122342 no 447 0.148406855646234 171 2865180 SGTC_207 4185-0010 4.486 µM 1.04302424312298 0.129627588260632 no 448 0.148468532414483 177 3761753 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.04259736586363 0.129726772556592 no 449 0.148567404881088 149 77254 SGTC_2144 5628481 200 µM 1.04153161004234 0.129974628703244 no 450 0.1488144452574 152 2818399 SGTC_1251 0490-5699 265 µM 1.03981731703742 0.130373998429576 no 451 0.149212391067307 176 3883818 SGTC_2570 licareol 100 µM 1.03883048065902 0.130604281024319 no 452 0.149441791395576 163 443158 SGTC_2432 5630864 12.22 µM 1.03871269146545 0.130631786425353 no 453 0.149469188430537 174 5714970 SGTC_653 0203-0016 55.2 µM 1.03870298073057 0.130634054194549 no 454 0.14947144723674 185 295302 SGTC_2964 9083345 53.42 µM 1.03691803406741 0.131051359092196 no 455 0.149887029244287 189 17741579 SGTC_3084 9116877 49.47 µM 1.03499256201691 0.131502549168707 no 456 0.150336192412821 149 27241325 SGTC_2415 st077333 57.7 µM 1.03491063982418 0.131521769502503 no 457 0.150355322627134 208 2766255 SGTC_1361 1608-0041 5.61 µM 1.03342754632709 0.131870063698184 no 458 0.15070193046919 192 X1361 SGTC_1522 st012842 45.6 µM 1.03320780326858 0.131921722897518 no 459 0.150753330959233 183 3491067 YOR116C RPO31 SGTC_41 0478-0632 82.643 µM 1.03299960585263 0.131970680718454 no 460 0.150802041555039 185 3750424 SGTC_44 0929-0055 61.211 µM 1.03295764136335 0.131980550225379 no 461 0.150811860982485 190 1379590 SGTC_2522 biochanin a 4.94 µM 1.03142466495576 0.132341435506737 no 462 0.151170859648959 164 5280373 A possible chelator. SGTC_244 nsc-207895 1.295 µM 1.03028705020874 0.132609686066547 no 463 0.151437638113416 133 42640 SGTC_1863 st057641 20.1 µM 1.03014942711427 0.132642163093424 no 464 0.151469932886929 193 3921635 SGTC_309 k408-0051 1.48 µM 1.02951142240249 0.132792794398382 no 465 0.151619707529943 195 3640463 SGTC_85 0868-0259 160.055 µM 1.02851158092796 0.133029091337149 no 466 0.15185462302992 162 83173 SGTC_2059 5238311 157 µM 1.02772677913161 0.13321476964344 no 467 0.152039183680936 183 703021 SGTC_54 0159-0055 9 µM 1.02628729359244 0.133555804652237 no 468 0.152378092401221 171 3319099 SGTC_852 0418-0143 439 µM 1.02609659776065 0.133601028258543 no 469 0.152423026914399 183 5369229 SGTC_2315 7733312 200 µM 1.02229293441693 0.134505268877562 no 470 0.153321138172466 169 726316 SGTC_2205 7238770 200 µM 1.02133007392361 0.134734833455629 no 471 0.153549041292843 169 279867 SGTC_3118 9124250 49.47 µM 1.018790102644 0.135341701292838 no 472 0.154151312731548 162 1504786 SGTC_2551 apiole 73.87 µM 1.01655572427457 0.135877101504936 no 473 0.15468241294466 155 10659 A possible DNA adduct former. SGTC_3139 9095020 49.47 µM 1.01614411307183 0.135975889475914 no 474 0.154780382533208 150 25236292 SGTC_1042 0350-0096 82 µM 1.01316184293147 0.136693112292952 no 475 0.155491431449272 179 3122515 SGTC_2239 6685329 187.64 µM 1.01187087297946 0.13700438562634 no 476 0.155799898766428 153 805680 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.01122516778853 0.137160256966562 no 477 0.155954336316389 187 676296 Flavone; oxidizing agent. SGTC_612 0302-0167 22.4 µM 1.01039339618043 0.13736122266711 no 478 0.156153425256238 198 235821 SGTC_1242 0402-0103 60.1 µM 1.01004496913433 0.137445466422689 no 479 0.156236872860398 178 432868 SGTC_136 0097-0015 404.482 µM 1.0097447126153 0.137518091653209 no 480 0.156308807278538 189 4861337 SGTC_1711 st032263 62.8 µM 1.00720129060579 0.138134338473273 no 481 0.156919026501812 190 3958979 SGTC_1128 3448-9350 235 µM 1.00414434641014 0.138877495056749 no 482 0.157654521419049 142 619386 SGTC_2033 5192550 145 µM 1.00412304866677 0.138882682163718 no 483 0.157659653546842 178 182073 SGTC_193 1273-0060 1.558 µM 1.00229291178748 0.139328908362603 no 484 0.158101072478248 180 2847393 YHR072W ERG7 SGTC_74 000s-0487 160.283 µM 1.00181700051959 0.139445105260033 no 485 0.158215992431131 175 677548 SGTC_2539 epi(13)torulosol 80 µM 0.999521724728556 0.140006437529459 no 486 0.158771010220474 174 6708597 SGTC_939 1165-0479 45.3 µM 0.998886761225099 0.140161994858711 no 487 0.15892477506158 179 1377347 SGTC_1803 st050068 52.4 µM 0.997217033605279 0.140571615319595 no 488 0.159329587344859 195 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2421 5690543 90.72 µM 0.99641549976905 0.140768537360162 no 489 0.159524152543643 195 3397993 SGTC_2636 apigenin dimethyl ether 100 µM 0.996230897171222 0.140813917311378 no 490 0.159568985204178 182 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_164 4100-3994 89.624 µM 0.993205723408937 0.14155899511152 no 491 0.160304854867565 205 4615967 SGTC_440 fluspirilene 35.1 µM 0.991501783204851 0.141979836792299 no 492 0.160720311026351 190 3396 An atypical antipsychotic. SGTC_205 1486-1330 71.903 µM 0.988191612579187 0.142799806519206 no 493 0.161529407556675 180 4118834 SGTC_1937 st074714 47.2 µM 0.984174831836081 0.143799103246251 no 494 0.162514779152905 158 17250970 SGTC_42 0133-0086 60.653 µM 0.98305283242111 0.144079075804096 no 495 0.162790718461289 227 162923 Model of phenazepam hydroxylation. SGTC_1936 st074407 74.3 µM 0.982399057535011 0.144242381657494 no 496 0.162951645229563 206 809813 SGTC_237 nikkomycin 200 µM 0.981280098337158 0.144522174932126 no 497 0.163227317085638 187 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1871 st057448 67.3 µM 0.981217451717379 0.144537850383047 no 498 0.163242759943365 199 691747 SGTC_984 1492-0255 2.91 µM 0.977427984821883 0.145488182240398 no 499 0.164178657082555 186 1585198 SGTC_2136 5328288 199.296 µM 0.972661833348832 0.146689403343298 no 500 0.165360700077373 161 262395 SGTC_2014 4013930 200 µM 0.972641663943793 0.146694500772119 no 501 0.165365713919982 209 64556 SGTC_1670 st016595 4.04 µM 0.972090874315882 0.146833748187936 no 502 0.165502670825922 222 597879 SGTC_6 0844-0013 19.835 µM 0.971168445153635 0.147067149873626 no 503 0.165732202251568 220 1584900 SGTC_2185 6113692 200 µM 0.969635522723547 0.14745557423607 no 504 0.166114099936939 190 874150 SGTC_1001 4048-4355 44.4 µM 0.969062170340454 0.147601031396492 no 505 0.166257085458849 198 21824233 SGTC_3014 9081533 49.47 µM 0.965121068962856 0.148603473116457 no 506 0.167242087610109 218 21367265 SGTC_2619 obliquin 87.91 µM 0.960143984577972 0.149875912292112 no 507 0.168491377066746 190 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1843 st055809 45.5 µM 0.958314653312376 0.150345419218061 no 508 0.168952058496749 191 16413835 SGTC_796 1234-0020 70.7 µM 0.95728076415774 0.150611204997492 no 509 0.169212780856779 180 46495034 SGTC_399 oxolinic acid 75 µM 0.9567433305029 0.150749488628179 no 510 0.16934841087929 195 4628 A DNA gyrase inhibitor. SGTC_2741 miltefosine 3.04 µM 0.955875924111033 0.150972853713132 no 511 0.169567461974233 152 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2211 7117706 200 µM 0.95112512918632 0.152200132200316 no 512 0.170770429823085 184 822771 SGTC_1306 1185-0270 9.02 µM 0.950284917877156 0.152417872417914 no 513 0.170983750137962 201 1548076 SGTC_1015 4130-4525 82 µM 0.950141321341483 0.152455106042836 no 514 0.171020224751966 200 1363237 SGTC_2765 myclobutanil 7.74 µM 0.950101886511475 0.152465332287875 no 515 0.171030242370256 216 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_669 0108-0021 26.2 µM 0.949424520087076 0.152641058096056 no 516 0.171202372157198 224 17201 SGTC_3195 9113082 49.47 µM 0.948759607489132 0.15281368369788 no 517 0.171371444923578 189 17018038 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.946588917094978 0.153378142527178 no 518 0.171924146794009 213 6728940 SGTC_2481 5478948 45.16 µM 0.941458764142271 0.154717652726593 no 519 0.173234905737608 188 77792 SGTC_2783 7738165 71.43 µM 0.941282487971948 0.154763816318857 no 520 0.173280057262519 195 17201110 SGTC_1944 st076371 56.9 µM 0.940204417740571 0.155046341725238 no 521 0.173556358093161 204 24208455 SGTC_293 4049-0273 38.5 µM 0.939742076099843 0.155167609966721 no 522 0.173674938434068 198 1380311 SGTC_2038 4100038 30.985 µM 0.938730214778753 0.155433230920337 no 523 0.173934638143363 202 3596803 SGTC_2433 5607874 27.82 µM 0.936690712963392 0.155969526243734 no 524 0.174458837381606 216 2252428 SGTC_463 ikarugamyin 104 µM 0.936574313224708 0.156000170776922 no 525 0.174488785051592 186 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2998 9066762 71.4286 µM 0.934439488030603 0.156562909509066 no 526 0.175038618223573 186 4945196 SGTC_1105 epirubicin 18.1 µM 0.932836833889869 0.156986245422707 no 527 0.175452110037443 212 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2194 5927483 104.545 µM 0.931181547120267 0.157424273839608 no 528 0.175879830746518 176 760979 SGTC_3341 9147222 25.867 µM 0.930732534871169 0.157543231579588 no 529 0.175995967816094 202 1939759 SGTC_2444 5485484 36.41 µM 0.928584427809257 0.158113151046857 no 530 0.176552247553037 223 6790631 SGTC_1669 st015249 58.4 µM 0.928571103962817 0.158116690246335 no 531 0.176555701399505 201 722793 SGTC_3174 9107204 49.47 µM 0.926734773917078 0.158604970128872 no 532 0.177032129003233 206 3938802 SGTC_1412 3909-8563 178 µM 0.92503794516187 0.1590570346561 no 533 0.177473084970995 219 23767530 SGTC_1182 1222-0449 220 µM 0.924937504742817 0.159083820158525 no 534 0.177499208202843 207 658318 SGTC_2383 9036125 200 µM 0.924904037735774 0.159092745813443 no 535 0.177507913070234 188 79580 SGTC_1941 st076221 61.8 µM 0.923286362292304 0.159524571233173 no 536 0.177928996492979 192 2828568 SGTC_1240 0356-0016 42.1 µM 0.922659653835634 0.159692072000445 no 537 0.178092298832872 191 4305613 SGTC_546 peri-Naphthalide 147 µM 0.921079755504423 0.160114842990739 no 538 0.178504394428888 209 223824 A penicillin ester. SGTC_695 3505-6186 243 µM 0.92065798037676 0.160227831038813 no 539 0.17861451039291 221 1819379 SGTC_1043 0916-0009 19.3 µM 0.91720602609393 0.161154522768718 no 540 0.179517344826149 218 3101130 SGTC_2625 euphol 100 µM 0.916396321492248 0.161372396717313 no 541 0.179729531995227 216 6708538 A triterpene alcohol. SGTC_2704 st078022 71.1 µM 0.915894958267075 0.161507398944024 no 542 0.179860995710902 192 54697681 SGTC_2398 5228213 48.84 µM 0.915446025514215 0.161628345673231 no 543 0.179978762740349 224 80771 YMR134W ERG29 SGTC_1950 st077106 7.18 µM 0.909280640706188 0.163295329778503 no 544 0.181601003418722 182 13831864 SGTC_2150 5556613 200 µM 0.908686332568683 0.163456605779241 no 545 0.181757860316349 209 743190 SGTC_911 3456-4043 236 µM 0.90124952688984 0.165483456975408 no 546 0.183727831638001 202 914281 SGTC_2206 7254556 146.969 µM 0.900462065721995 0.165699022061644 no 547 0.18393720203919 181 4398905 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.899544327879823 0.165950478987836 no 548 0.184181397838055 215 16623 A steroid. SGTC_2536 dehydroabietamide 32.04 µM 0.899281298134183 0.166022593654242 no 549 0.184251423157935 185 3983547 SGTC_3111 9122088 49.47 µM 0.899129263699127 0.166064286053783 no 550 0.184291906210834 194 16876704 SGTC_2753 fluvastatin 17.09 µM 0.891955952415232 0.168039110402404 no 551 0.186208271155667 209 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1166 k206-0078 225 µM 0.890393616312616 0.16847122027154 no 552 0.186627284463143 203 5404595 SGTC_955 1216-0110 33 µM 0.887901342283392 0.169162009282793 no 553 0.18729691132193 202 3619719 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.885331591201859 0.169876174376615 no 554 0.187988908132187 183 6708630 An antioxidant. SGTC_738 1315-0003 72.4 µM 0.88530910769921 0.169882431334218 no 555 0.187994969571189 229 6251474 SGTC_141 0443-0274 32.331 µM 0.88505076056654 0.169954337632767 no 556 0.1880646273142 198 1627241 SGTC_2740 felodipine 17.08 µM 0.884255960978221 0.170175678193529 no 557 0.188279027794504 177 3333 L-type calcium channel blocker SGTC_1313 1220-0047 237 µM 0.88274419876222 0.170597192357902 no 558 0.188687247911007 212 3528706 SGTC_1017 4239-0030 168 µM 0.882365158964336 0.17070298211243 no 559 0.188789685250749 218 1149593 SGTC_477 mead ethanolamide 10 µM 0.880343884676763 0.171267827219492 no 560 0.189336522901585 160 16061185 SGTC_481 bay k-8644 50 µM 0.876652561389556 0.172302447499187 no 561 0.190337690364001 221 2303 A calcium channel antagonist. SGTC_2341 7987486 176.74 µM 0.876140893536822 0.172446174038841 no 562 0.190476722005194 201 1258686 SGTC_548 1436-0017 110 µM 0.875797523088253 0.172542669017423 no 563 0.190570058419841 201 9677137 SGTC_134 0269-0018 6.916 µM 0.875495407182428 0.172627598992157 no 564 0.19065220406546 211 4378915 SGTC_3127 9126946 49.47 µM 0.875125495084015 0.172731623932326 no 565 0.190752813162165 197 27243249 SGTC_1625 st003711 30.1 µM 0.872838110954642 0.173375758549285 no 566 0.191375661755782 212 24207034 YER133W GLC7 SGTC_301 4119-0100 24.5 µM 0.871989492376293 0.173615120621716 no 567 0.191607054941075 226 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_24 0417-1663 219 µM 0.871289186737045 0.173812807701026 no 568 0.191798136578921 220 4329390 SGTC_1062 mesoridazine 14.2 µM 0.870258084801129 0.174104134697453 no 569 0.192079689786372 203 4078 A neuroleptic. SGTC_1848 st056003 16.4 µM 0.870240400655276 0.174109133872459 no 570 0.192084520832908 210 146492 SGTC_2022 5136654 200 µM 0.867787870652656 0.174803329341236 no 571 0.192755235657688 231 1713771 SGTC_304 1310-0298 97 µM 0.8674441557908 0.174900758965909 no 572 0.192849348556811 249 1550234 SGTC_350 k064-0020 19.8 µM 0.86596276287901 0.17532106974304 no 573 0.19325529128318 216 2790705 SGTC_858 0438-0351 2.77 µM 0.864679319750363 0.175685734215778 no 574 0.193607411586156 230 2799119 SGTC_2778 tioconazole 65.09 nM 0.863248277542931 0.176092902199854 no 575 0.194000487593726 230 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_127 0180-0333 59.125 µM 0.861858322003232 0.176488951390488 no 576 0.194382743153091 183 771601 SGTC_1363 1636-0063 10.4 µM 0.861713686970899 0.176530195543439 no 577 0.194422545960942 238 6072185 SGTC_2175 5807670 165.306 µM 0.860948612499427 0.176748465721032 no 578 0.194633172996023 191 241186 SGTC_2884 9058502 51.95 µM 0.858400965138741 0.17747652028408 no 579 0.195335547423 206 6471554 SGTC_571 k831-0106 44.2 µM 0.858183771832036 0.177538676207775 no 580 0.195395497750401 230 4783639 SGTC_999 SEC7.066 22.7 µM 0.857682715250617 0.177682119926834 no 581 0.195533843470511 227 740511 YDR170C SEC7 SGTC_408 cantharidin 100 µM 0.856783580222389 0.177939709821955 no 582 0.195782250921247 206 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1494 4358-1428 177 µM 0.856485211285644 0.178025240457804 no 583 0.19586472474749 197 1564571 SGTC_2557 derrustone 83.84 µM 0.855974317339204 0.178171753834771 no 584 0.196005992746241 234 629853 An antioxidant. SGTC_2581 avocatin a 64 µM 0.855196627784391 0.178394924300067 no 585 0.196221151387929 203 6710728 A skin care supplement. SGTC_2886 9058944 51.95 µM 0.854847913083459 0.178495050729526 no 586 0.196317674649902 173 4949929 SGTC_1615 st002656 86.5 µM 0.851290282625028 0.179518574881185 no 587 0.197304060770535 204 1584458 SGTC_2401 5128683 200 µM 0.850739984871558 0.179677223402228 no 588 0.197456903210414 221 708373 SGTC_2819 7996655 46.38 µM 0.850577822890843 0.179723990817315 no 589 0.197501956540349 194 6456960 SGTC_1459 k035-0031 35.7 µM 0.848872362268562 0.180216307697436 no 590 0.197976159578048 201 3877128 YMR208W ERG12 SGTC_2882 9058044 58.44 µM 0.847023495753476 0.180750976883384 no 591 0.198491012678106 227 18076804 SGTC_712 r015-0009 80.6 µM 0.846698861337529 0.180844959651241 no 592 0.198581496784277 213 6813872 YLR060W FRS1 SGTC_792 4534-1957 155 µM 0.844306282992196 0.181538563660744 no 593 0.199249138027371 205 1717904 SGTC_604 1000-0114 314 µM 0.842172945159209 0.182158416511375 no 594 0.199845577627038 230 1572745 SGTC_61 0978-8327 98.565 µM 0.839775706971054 0.182856523526914 no 595 0.200517078346184 215 6150059 YHR072W ERG7 SGTC_1307 1187-1599 12.2 µM 0.834603649418113 0.18436837265218 no 596 0.201970453354034 239 1538471 SGTC_317 4495-0002 170 µM 0.832475707025218 0.184992645084645 no 597 0.202570242392428 203 15991618 SGTC_3200 9114385 49.47 µM 0.831940366601634 0.18514990392233 no 598 0.202721302709092 211 17018030 YLR208W SEC13 SGTC_1127 asiatic acid 681.4 nM 0.83159999705777 0.185249932287009 no 599 0.202817381881936 235 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1718 roemerine 11.9335 µM 0.831426004132215 0.185301078575399 no 600 0.202866506936062 222 235224 An aporphine alkaloid with mutagenic activity. SGTC_478 N-arachidonylglycine 10 µM 0.83125594184293 0.185351077901435 no 601 0.202914529084834 183 5283389 SGTC_2146 5545642 200 µM 0.830544855129141 0.185560232350277 no 602 0.203115399119828 218 825326 SGTC_2134 5324836 1.464 µM 0.827090329056564 0.186578407080205 no 603 0.204092932623347 240 699272 SGTC_1573 oleylamine 1.06 µM 0.826947997950676 0.186620431313736 no 604 0.204133268333842 242 5356789 An amine of the fatty acid oleic acid. SGTC_302 1094-0063 18.9 µM 0.826585239087876 0.186727564852461 no 605 0.204236093308538 241 5440289 SGTC_1285 0929-0069 65.5 µM 0.821262094962326 0.188304023892616 no 606 0.205748496817119 218 1206237 SGTC_2850 9015429 58.44 µM 0.82054094211842 0.188518224416062 no 607 0.205953899613506 253 6457570 SGTC_1115 galangin 695.678 nM 0.819918530145347 0.188703217167518 no 608 0.206131276232173 248 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2277 7947813 106.88 µM 0.817522250324013 0.189416481523189 no 609 0.206815019555228 218 1246798 SGTC_3207 9114163 49.47 µM 0.816807076516365 0.189629677575177 no 610 0.207019343769296 259 849233 SGTC_1345 1488-0192 31.4 µM 0.816777135056835 0.189638606457188 no 611 0.207027900608937 216 658348 SGTC_2716 st080858 38.6235 µM 0.815903703992651 0.189899187284579 no 612 0.207277606758127 230 5296050 SGTC_2204 7233102 200 µM 0.813038268764899 0.190755610470979 no 613 0.208098058741277 225 2172480 SGTC_1474 0330-0125 5.35 µM 0.812525059094487 0.190909248811645 no 614 0.208245206747071 229 X1474 SGTC_1226 3909-7979 35.4 µM 0.809701295242996 0.191755949348348 no 615 0.209055936712053 246 6615510 SGTC_1473 k844-0725 134 µM 0.806542578059673 0.19270580498838 no 616 0.209965033949031 252 54682906 SGTC_1790 st045711 43.5 µM 0.804850776036573 0.193215725818398 no 617 0.210452898292711 193 585119 SGTC_901 1112-0062 60.1 µM 0.804737862334942 0.193249788081527 no 618 0.210485482845755 244 1908457 SGTC_1217 1183-1422 255 µM 0.80425785488194 0.193394631074911 no 619 0.210624036090733 239 2849664 SGTC_541 4513-1321 94 µM 0.804141699101431 0.193429691212911 no 620 0.210657572277289 240 747515 SGTC_2323 6148992 148.28 µM 0.801854130064079 0.194120954626047 no 621 0.211318671237085 231 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.801392647629711 0.194260588752725 no 622 0.211452185114889 273 368090 SGTC_2461 5755302 26.15 µM 0.799531768113129 0.19482426906013 no 623 0.211991066808889 257 2788904 SGTC_2425 5628681 7.85 µM 0.798861280038379 0.195027610615501 no 624 0.212185426366798 255 5714958 SGTC_866 0495-0101 262 µM 0.79854640459495 0.195123148637217 no 625 0.212276737680188 222 635694 SGTC_2213 7173844 200 µM 0.797898472943063 0.195319830474882 no 626 0.212464704817285 246 892728 SGTC_1687 st020778 55.3625 µM 0.795482480731967 0.196054274332833 no 627 0.213166448950635 232 4259299 SGTC_679 0422-0091 41.4 µM 0.795386750076934 0.196083410208211 no 628 0.21319428249498 255 627384 YHR062C RPP1 SGTC_3093 9117344 49.47 µM 0.793822040619611 0.196560005806533 no 629 0.213649519781617 231 24824913 SGTC_1806 st050005 60.3 µM 0.793758489314322 0.196579377749206 no 630 0.213668021387103 224 5194765 SGTC_2934 9036370 36.88 µM 0.789005595372673 0.198031448564925 no 631 0.215054368109534 210 6462800 SGTC_1012 4112-3522 18 µM 0.788343665706887 0.198234189297324 no 632 0.215247856386934 224 3112398 SGTC_3226 9131256 49.47 µM 0.787885686498867 0.198374535872867 no 633 0.215381787137277 217 17178073 SGTC_327 1273-0057 3.96 µM 0.786732548489191 0.19872817756458 no 634 0.215719223126836 235 3108138 SGTC_588 3970-1144 52.9 µM 0.7864712472379 0.198808365622768 no 635 0.215795728743155 210 1888707 SGTC_2931 9014674 55.67 µM 0.784609602950609 0.199380230858784 no 636 0.216341248996915 249 2996810 SGTC_1367 1812-0510 76.9 µM 0.784057315237284 0.199550074487513 no 637 0.216503240049809 226 1142582 YDR527W RBA50 SGTC_1583 clindamycin 39.6 µM 0.782229845698071 0.200112691975888 no 638 0.217039753698853 248 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2182 6325192 200 µM 0.782074205084163 0.200160652598892 no 639 0.217085482584236 226 736248 SGTC_1437 4092-1038 11.6 µM 0.781157337917911 0.200443325221774 no 640 0.217354980983568 261 3977136 SGTC_831 k061-1017 217 µM 0.779372762511625 0.200994201701993 no 641 0.217880081885817 261 1240153 SGTC_881 0833-0569 170 µM 0.779244185687669 0.201033926830756 no 642 0.217917943099225 239 5418700 SGTC_1149 3909-7961 23.3 µM 0.778132840363671 0.201377484606072 no 643 0.218245352084993 230 735261 SGTC_627 1391-0720 175 µM 0.777769216361802 0.201489970541592 no 644 0.218352539402545 272 997839 SGTC_2932 9016711 44.54 µM 0.774016649237734 0.202653013024193 no 645 0.219460472808828 236 7117328 SGTC_1163 k060-0048 49.9 µM 0.772602652136648 0.203092295332101 no 646 0.219878787216683 240 6809982 SGTC_284 0988-0104 32.6 µM 0.772584613226904 0.20309790309712 no 647 0.219884126770441 259 4666532 SGTC_2742 clothiapine 36.27 µM 0.771482592828761 0.203440664044081 no 648 0.220210468148004 216 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_582 0987-0078 156 µM 0.770976055852074 0.203598327725862 no 649 0.220360562101167 256 1625765 SGTC_532 1548-0774 215 µM 0.770567527479344 0.20372553851349 no 650 0.220481657451474 267 5932993 SGTC_445 e6 berbamine 66 µM 0.766509603625282 0.20499169793632 no 651 0.221686569890256 261 6610268 A calcium/calmodulin antagonist. SGTC_1739 st037196 92.5 µM 0.766450189962899 0.205010270955092 no 652 0.221704239389684 239 612214 SGTC_697 0508-1955 564 µM 0.765670994935946 0.205253943929768 no 653 0.221936044832377 240 6243113 SGTC_2987 9018338 71.43 µM 0.764512544485452 0.205616537076891 no 654 0.222280931998261 262 5055682 SGTC_687 k029-0044 34.9 µM 0.764466423816618 0.205630980638737 no 655 0.222294669103433 229 5829338 SGTC_3284 9108171 64.8615 µM 0.764158122780994 0.205727546420649 no 656 0.222386509434154 240 8687505 SGTC_3354 9151612 71.43 µM 0.763828516134999 0.205830815287533 no 657 0.222484720464118 233 27261949 SGTC_2261 9010538 184.68 µM 0.763701462767268 0.205870630515739 no 658 0.222522584441812 285 6457250 SGTC_84 0443-0269 128.823 µM 0.762177612371768 0.206348521620105 no 659 0.222977002961582 236 6150058 SGTC_817 1391-0715 46 µM 0.761276710001633 0.20663136042562 no 660 0.223245904211912 272 1353946 SGTC_3213 9129884 49.47 µM 0.760096090943705 0.207002363823204 no 661 0.223598574554759 239 17190742 SGTC_3214 9129694 49.47 µM 0.758491466659311 0.207507240069923 no 662 0.224078409805585 259 17158655 SGTC_2335 9018011 154.17 µM 0.757930293147667 0.20768397836828 no 663 0.224246357021598 231 6458208 SGTC_2944 9067346 25.62 µM 0.757276379041143 0.207890036922427 no 664 0.224442149645739 264 6473075 SGTC_2624 nerol 100 µM 0.757031409087058 0.207967261857034 no 665 0.224515522645899 268 637566 A natural product oil. SGTC_2764 methyldopa 94.69 µM 0.753771397444589 0.208996567404466 no 666 0.225493250811678 254 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3203 9113543 49.47 µM 0.753030000765559 0.209231071697239 no 667 0.225715943103564 244 17018012 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.749272508150145 0.210421948804106 no 668 0.226846487161723 249 689007 SGTC_2920 7982904 15.77 µM 0.748824472583088 0.210564211523976 no 669 0.226981503698108 239 6456808 SGTC_2957 9076800 11.52 µM 0.748511579304494 0.210663596584275 no 670 0.227075821667579 262 16459615 SGTC_2078 5212016 200 µM 0.74830187749345 0.210730220085907 no 671 0.227139046157488 250 1899708 SGTC_1572 epiandrosterone 68.9 µM 0.74755485093278 0.210967655244411 no 672 0.227364353126365 233 441302 A steroid. SGTC_3337 9144342 33.5465 µM 0.746753820900933 0.211222429060417 no 673 0.227606087644978 241 17682949 SGTC_1983 st071813 46.9 µM 0.746212254889713 0.211394780426816 no 674 0.227769603173556 245 11838595 SGTC_144 4161-2749 112.381 µM 0.742647822187813 0.212531201233952 no 675 0.228847463720057 263 797501 YMR168C CEP3 SGTC_1524 corynanthine 62.1 µM 0.741698362349359 0.212834511040535 no 676 0.229135056129362 269 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1407 3909-7909 12.3 µM 0.740981302937466 0.213063746712413 no 677 0.229352388486675 241 4411780 SGTC_2417 cerulenin 830 nM 0.740964962969031 0.213068972090933 no 678 0.22935734228704 262 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2792 7535235 81.82 µM 0.7408036313092 0.213120568552992 no 679 0.229406256545621 250 1281891 SGTC_2750 bromebric acid 70.15 µM 0.739843348097689 0.213427833343619 no 680 0.229697526427837 246 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2504 purpurogallin 52.29 µM 0.7394995259132 0.213537909937329 no 681 0.229801863753407 249 5281571 An antioxidant. SGTC_1377 2944-0135 198 µM 0.738313430313022 0.213917898899602 no 682 0.230162003532743 233 1894137 SGTC_3271 9137798 49.47 µM 0.73729580598404 0.214244228338806 no 683 0.230471241073027 230 6498326 SGTC_2409 alverine citrate 63.97 µM 0.737105781240668 0.214305197110883 no 684 0.230529011861201 225 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1505 k297-0037 20.6 µM 0.736967391185935 0.214349605424831 no 685 0.230571089909367 256 4089396 SGTC_648 0375-0473 33.3 µM 0.736579535436973 0.214474093894874 no 686 0.230689041864926 259 1713139 SGTC_1195 1502-0147 41.1 µM 0.73558169591376 0.214794559483223 no 687 0.230992652652292 252 817940 SGTC_859 0439-0102 54.6 µM 0.735109541167758 0.214946293350752 no 688 0.231136392011887 273 610143 SGTC_3327 9140648 26.9345 µM 0.734734180117744 0.215066965546151 no 689 0.231250699805753 276 8029710 SGTC_2860 9025725 38.96 µM 0.734652075550364 0.215093366010448 no 690 0.231275707114136 242 40546248 SGTC_1220 1838-0075 193 µM 0.7342397431154 0.21522597865063 no 691 0.231401317629507 245 5529645 SGTC_114 0364-0001 490.298 µM 0.73344731584383 0.21548096899448 no 692 0.231642824765793 260 4003655 SGTC_2077 5212015 200 µM 0.733411465352546 0.215492509247302 no 693 0.23165375419854 250 780900 SGTC_376 3970-0862 59.1 µM 0.732362048542487 0.215830474720767 no 694 0.231973808225617 276 3135186 SGTC_1529 apigenin 74 µM 0.732355198877391 0.215832681669161 no 695 0.231975898063824 263 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1977 st070720 65.3 µM 0.731968647593464 0.215957248913323 no 696 0.23209385215256 240 682188 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.731457075647243 0.216122168442244 no 697 0.232250006955011 262 75037 A free radical scavenger. SGTC_978 1416-0512 87.4 µM 0.731376776484827 0.216148061745222 no 698 0.23227452318378 271 6814003 SGTC_1382 3002-2117 298 µM 0.73108149257084 0.216243294573823 no 699 0.232364689034054 287 1497314 SGTC_1969 st069479 40.1 µM 0.730609213558157 0.216395661068022 no 700 0.232508941346622 266 3895485 SGTC_1222 0366-0074 1.18 µM 0.730421428121668 0.216456261602153 no 701 0.232566312129515 264 286520 SGTC_2378 9074213 121.43 µM 0.730299194506326 0.216495713081027 no 702 0.23260366024549 265 657714 SGTC_3125 9127534 49.47 µM 0.729226531780058 0.216842098476413 no 703 0.232931552116209 237 1639235 SGTC_2729 fluphenazine 10.66 µM 0.729055083540166 0.216897492409506 no 704 0.232983984254022 272 3372 An atypical antipsychotic. SGTC_59 0330-0160 1.33 µM 0.728905960945006 0.216945679707141 no 705 0.233029594113939 270 4293482 SGTC_1588 farnesol 29.9 µM 0.728360556136412 0.217121973860781 no 706 0.233196451010004 257 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2025 5147754 141 µM 0.727889483151485 0.217274307931735 no 707 0.233340620767929 246 315777 YLR208W SEC13 SGTC_664 1222-0054 14.9 µM 0.72783999038556 0.217290316326195 no 708 0.233355770675714 261 6813991 SGTC_14 0354-0009 295 µM 0.727498237988663 0.217400874447595 no 709 0.233460397167155 278 1713507 SGTC_2877 9040724 71.43 µM 0.727313089389629 0.217460784242481 no 710 0.233517090731859 252 6463895 SGTC_1525 8-methoxypsoralen 92.5 µM 0.725612297815274 0.218011566692335 no 711 0.234038239967196 268 4114 Related to psoralen; DNA damaging agent. SGTC_2748 diazoxide 86.69 µM 0.725537334881597 0.218035861096155 no 712 0.234061224599533 205 3019 A potassium channel activatior. SGTC_2899 9053889 58.44 µM 0.723930662081689 0.218556935610919 no 713 0.234554152278361 250 6470052 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.722268375952688 0.219096800460105 no 714 0.23506474593159 251 88881 An O-methylated flavonoid and antioxidant. SGTC_2775 cyproheptadine 69.59 µM 0.722098045342413 0.219152162439166 no 715 0.235117099939073 269 2913 A selective serotonin reuptake inhibitor. SGTC_1324 1418-0026 34.4 µM 0.721354840357596 0.219393817914657 no 716 0.235345611961001 252 1372513 SGTC_2966 9084041 48.03 µM 0.720135792128202 0.219790526696514 no 717 0.235720696045069 243 17741380 SGTC_1428 4049-0204 61.7 µM 0.717426046306486 0.220673819147896 no 718 0.236555626497391 277 X1428 SGTC_1841 st054148 70 µM 0.71727864449178 0.220721925773352 no 719 0.236601090759253 272 675442 SGTC_1434 4073-0095 163 µM 0.716113319341005 0.221102457174097 no 720 0.236960690039287 263 24133745 SGTC_1867 st057372 64 µM 0.71536308547366 0.221347640989017 no 721 0.237192358163679 244 688837 SGTC_745 0469-0705 296 µM 0.709477501834636 0.223276494008661 no 722 0.239014104066277 288 3486736 SGTC_1875 nocodazole 6 µM 0.708687228092181 0.223536213012559 no 723 0.239259296157361 266 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2839 9003951 25.97 µM 0.708681884050786 0.223537969886324 no 724 0.239260954679203 247 2990634 SGTC_1419 3993-2473 62.6 µM 0.707950216649032 0.223778582441147 no 725 0.239488086755821 280 704026 SGTC_1782 st039423 80.636 µM 0.707552464684878 0.223909446948794 no 726 0.239611610585308 272 2068169 SGTC_2328 6201408 200 µM 0.707530520904472 0.223916667944954 no 727 0.239618426346356 294 2890418 SGTC_269 exalamide 29 µM 0.706433742009499 0.224277751352132 no 728 0.239959221801943 260 3316 A derivative of salicylamide. SGTC_2324 6149169 200 µM 0.705929272372675 0.224443944633372 no 729 0.240116061296417 254 2888231 SGTC_1974 st069448 26.9 µM 0.705725651068964 0.224511045753354 no 730 0.24017938293911 254 6323587 YNR016C ACC1 SGTC_3153 9100258 49.47 µM 0.705298125609063 0.224651969013494 no 731 0.240312363344917 271 25236848 SGTC_3302 9125395 16.351 µM 0.704178066277217 0.22502140685783 no 732 0.240660944295566 255 17599668 SGTC_2769 toremifene 3.73 µM 0.703752844561785 0.225161751142596 no 733 0.240793352352953 266 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_693 4161-2696 114 µM 0.703656829631454 0.225193447699231 no 734 0.240823255535708 284 805759 SGTC_2278 7948257 134.34 µM 0.701600899965534 0.225872759716374 no 735 0.241464045115009 269 1247028 SGTC_2305 7443522 69.23 µM 0.701498143940863 0.225906742327974 no 736 0.241496096265729 265 5415886 SGTC_1810 st050138 53 µM 0.701251341730695 0.22598837449653 no 737 0.241573087028285 297 3444541 SGTC_2180 6301957 200 µM 0.701108320604493 0.226035687719559 no 738 0.241617709038665 266 845462 SGTC_65 0798-0905 34.986 µM 0.70047606384599 0.226244913440945 no 739 0.241815024186371 297 3602145 SGTC_1248 0469-0687 58.6 µM 0.700293119399642 0.226305473622708 no 740 0.241872133928246 258 4017482 SGTC_2004 4023728 41.89 µM 0.700160034708311 0.226349534460515 no 741 0.241913683555046 293 360084 YDR527W RBA50 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.700125195544505 0.226361069590681 no 742 0.241924561134899 265 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2381 9035592 200 µM 0.697563629991941 0.227210104487603 no 743 0.242725066684289 265 4749657 SGTC_1882 5615643 20 µM 0.697210061846332 0.22732743600352 no 744 0.242835671485468 261 2253075 SGTC_389 tpck 16.7 µM 0.696871181291958 0.227439925479171 no 745 0.242941707240472 255 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_417 st075190 100 µM 0.696717815357344 0.227490844734282 no 746 0.242989703686885 281 222757 SGTC_2768 sulfasalazine 50.2 µM 0.69655850912998 0.227543743032549 no 747 0.243039564600918 287 5384001 An antioxidant and salicylic acid derivative. SGTC_1050 3232-1156 69.3 µM 0.696181596367285 0.227668926067199 no 748 0.243157555748427 272 700529 SGTC_864 0469-0573 172 µM 0.695856685139941 0.227776869078661 no 749 0.243259292859192 278 689425 SGTC_2196 6573537 42.6665 µM 0.692142345864278 0.229012903145265 no 750 0.244423970463581 288 2903087 SGTC_162 k030-0015 37.8 µM 0.692079861039294 0.229033728580655 no 751 0.244443589028427 294 1809920 YMR134W ERG29 SGTC_619 1652-1634 108 µM 0.691953141516516 0.229075965924794 no 752 0.244483378176336 273 5400454 SGTC_2825 7998094 58.44 µM 0.691832757925966 0.229116095463217 no 753 0.244521181112353 258 2987815 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.691615608817111 0.229188491490857 no 754 0.244589378383258 265 97141 SGTC_2891 9063876 19.48 µM 0.691456086904155 0.229241683178173 no 755 0.24463948393674 260 6472478 SGTC_2508 celastrol 40.54 µM 0.691211217841875 0.229323346860321 no 756 0.244716407633861 240 122724 Celastrol is a natural product and antioxidant. SGTC_2253 7938677 135.83 µM 0.689868748868719 0.229771349123184 no 757 0.245138365053694 253 2301972 SGTC_903 1134-0042 114 µM 0.689179061755922 0.230001698606874 no 758 0.245355295739753 285 701009 SGTC_1614 st002383 48.6 µM 0.689096108354106 0.230029413024274 no 759 0.245381394431471 248 1947235 SGTC_1968 st069590 43.6 µM 0.686402286269136 0.23093042384055 no 760 0.246229731583592 277 6384066 SGTC_2306 7482397 179.52 µM 0.683644288674369 0.231854937471182 no 761 0.247099905445235 295 891448 SGTC_1674 st016616 23.6 µM 0.683137043174299 0.232025196370179 no 762 0.247260125012097 265 625830 SGTC_893 0958-0369 48.9 µM 0.682339043104992 0.232293188996514 no 763 0.247512295278366 280 6819948 SGTC_1442 4112-3290 3 µM 0.682092815486482 0.232375914452955 no 764 0.247590131629865 288 704353 SGTC_2594 a-mangostin 100 µM 0.681497883923731 0.232575862104919 no 765 0.247778252632685 286 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1140 3229-1848 2.98 µM 0.681349272613607 0.232625823083262 no 766 0.247825256348589 278 2849525 SGTC_2054 5233173 129 µM 0.681198711340626 0.232676445694465 no 767 0.247872881664703 223 6889 SGTC_1403 3909-7815 62.9 µM 0.681180113616115 0.232682699157424 no 768 0.247878764808004 274 6615483 SGTC_1297 1068-0111 14.1 µM 0.680961497451567 0.232756215587966 no 769 0.247947926717028 277 767057 SGTC_790 1575-0012 79.1 µM 0.680491729094833 0.232914233352636 no 770 0.24809657854047 283 378741 YLR208W SEC13 SGTC_2212 7123476 200 µM 0.680225894829331 0.233003679428715 no 771 0.248180719245829 254 1085715 SGTC_1805 st050013 60.3 µM 0.68013329739396 0.233034840452848 no 772 0.24821003135669 274 4037144 SGTC_1454 4239-0054 42.6 µM 0.679163021521308 0.233361498239425 no 773 0.24851728729367 273 1340767 SGTC_2062 5245942 200 µM 0.678666960746035 0.233528602567399 no 774 0.248674452438229 277 1376160 SGTC_2699 st077704 54.6 µM 0.67848196942639 0.233590936210985 no 775 0.248733076118599 275 645852 SGTC_2259 7964009 200 µM 0.678201751353616 0.233685374500268 no 776 0.248821891136537 256 313134 SGTC_2312 7706453 155.7 µM 0.678173949656614 0.233694745302314 no 777 0.248830703794991 272 976098 SGTC_2851 9015922 71.43 µM 0.675387753396888 0.23463491262883 no 778 0.249714722063218 285 2996893 SGTC_106 0092-0003 11.579 µM 0.672350352436135 0.235662224540048 no 779 0.250680340717369 271 1072148 SGTC_1321 1326-2144 215 µM 0.67230654561381 0.235677059040007 no 780 0.250694281774839 293 3513030 SGTC_3301 9125354 19.7965 µM 0.672061173014326 0.235760160180241 no 781 0.250772376597583 259 41905162 SGTC_755 1995-0008 37.3 µM 0.671377874220898 0.235991660337679 no 782 0.250989918205478 254 689533 SGTC_368 fentichlor 4.58 µM 0.670490675714816 0.23629242810177 no 783 0.251272524233408 297 7329 A pesticide. SGTC_940 3232-1287 54.8 µM 0.668691689154863 0.236902947099604 no 784 0.251846085052361 280 1585493 YIL048W NEO1 SGTC_200 k038-0079 37.545 µM 0.667421333257393 0.237334587475325 no 785 0.252251521466573 302 3436683 SGTC_2044 5102272 200 µM 0.666786700025007 0.23755038423888 no 786 0.252454194664259 278 592666 SGTC_1794 st048918 76.9 µM 0.6666591941435 0.237593753538647 no 787 0.252494924635491 250 672303 SGTC_2256 7954252 200 µM 0.665061295257013 0.238137624215594 no 788 0.253005644548313 291 2972920 SGTC_556 4058-0063 51.5 µM 0.664748574284583 0.238244143611032 no 789 0.253105659881834 277 6615692 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.663022740639427 0.238832468399154 no 790 0.253657994911287 272 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_573 3702-0553 84.7 µM 0.662277515688896 0.239086755883781 no 791 0.253896691914216 271 1222756 SGTC_1469 k284-2957 126 µM 0.661124095258601 0.239480620438833 no 792 0.254266367029008 277 23884841 SGTC_545 4218-0007 221 µM 0.660404545194502 0.239726508328431 no 793 0.25449712809224 298 2840508 SGTC_2061 5245884 80.95 µM 0.659798460595062 0.239933729133138 no 794 0.25469158567202 296 573863 SGTC_2273 7815444 169.05 µM 0.659704850225104 0.239965743299805 no 795 0.254721626774021 325 2824616 SGTC_414 piperonyl butoxide 100 µM 0.658845309486304 0.240259809773273 no 796 0.254997554192853 282 5794 A potent inhibitor of cytochrome P450. SGTC_2386 9075165 157.42 µM 0.658762959483944 0.240287993698051 no 797 0.255023998172191 280 16452277 SGTC_2092 5303694 80.6725 µM 0.658504426046499 0.240376487329613 no 798 0.255107026955289 280 1963699 SGTC_1698 5-fluorocytosine 1.055 µM 0.658484928217228 0.240383161978138 no 799 0.255113289314512 284 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2318 6029776 164 µM 0.657208580064776 0.240820310941398 no 800 0.25552340469083 299 818325 SGTC_3289 9119912 71.43 µM 0.657066118225385 0.240869130909618 no 801 0.255569201796246 296 17014829 SGTC_1139 k015-0024 46.9 µM 0.656534824342377 0.241051246440247 no 802 0.255740034263176 287 2766652 SGTC_2736 butenafine 14.65 µM 0.655946663434508 0.241252941990569 no 803 0.255929221286072 287 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2369 9071472 200 µM 0.655812250718024 0.241299048450738 no 804 0.255972466543631 291 17296037 SGTC_336 4111-0029 111 µM 0.655385259030508 0.241445547566803 no 805 0.256109869946363 295 3131175 SGTC_3299 9121982 43.1275 µM 0.653789946581924 0.241993319991946 no 806 0.256623572202748 287 17594604 YPL160W CDC60 SGTC_1264 0783-0040 158 µM 0.653226453083575 0.242186964185736 no 807 0.256805149377944 294 2855798 SGTC_262 fenpropimorph 62.5 µM 0.65215992602657 0.242553705391859 no 808 0.257149004409014 307 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3038 9091290 49.47 µM 0.651713394443332 0.242707341198468 no 809 0.257293040066519 292 25236843 SGTC_2458 5808907 16.39 µM 0.651056665942169 0.242933394050163 no 810 0.257504954148852 302 2731747 SGTC_3124 9127567 49.47 µM 0.650638454510112 0.243077406162501 no 811 0.257639950440964 276 17592030 SGTC_2861 9024595 19.48 µM 0.649418324662527 0.243497824518913 no 812 0.258034011370901 262 16482810 SGTC_774 k060-0086 136 µM 0.649015722857733 0.24363663457205 no 813 0.25816410677864 296 5911235 SGTC_568 1193-0097 7.48 µM 0.647279627495758 0.244235698956388 no 814 0.258725492098978 269 3646150 SGTC_1907 st060210 83.7 µM 0.645960309010497 0.244691479051648 no 815 0.259152530233019 297 688793 SGTC_3021 9087658 49.47 µM 0.644777473638247 0.245100497868137 no 816 0.259535700948765 283 25237042 SGTC_2009 4012297 12.05 µM 0.644568819100129 0.245172687745943 no 817 0.259603323375848 294 45595307 SGTC_1453 4237-0541 195 µM 0.643547690749284 0.245526140514316 no 818 0.25993438993648 272 739892 SGTC_1976 st070609 63.5 µM 0.643324743128048 0.245603347865511 no 819 0.26000670216455 284 682556 SGTC_1172 0370-0043 85 µM 0.643024565249494 0.245707320853966 no 820 0.26010408012187 287 376585 SGTC_1336 1486-0901 104 µM 0.642092043831938 0.246030470166789 no 821 0.260406710739259 281 5006114 SGTC_553 k007-0256 45.7 µM 0.638225142201182 0.24737290817367 no 822 0.261663566483581 294 6287000 SGTC_1462 k081-0014 26.5 µM 0.638071117220733 0.247426460623684 no 823 0.261713693481745 265 3270634 SGTC_1621 st003705 32.4 µM 0.637752002188631 0.247537432415936 no 824 0.261817564251219 294 24207032 SGTC_1989 st071868 50.2 µM 0.636216168252413 0.24807188819807 no 825 0.262317768163277 293 16414057 SGTC_2282 7944268 200 µM 0.635845129974778 0.24820109829688 no 826 0.26243868453956 293 2970414 SGTC_1257 0669-0121 16 µM 0.635242926477588 0.248410885575863 no 827 0.262634995272357 304 4307855 SGTC_2638 epoxomicin 18 µM 0.6350427966883 0.24848062492523 no 828 0.262700251686408 289 9915668 A protesome inhibitor. SGTC_2995 9067767 71.4286 µM 0.634626775153314 0.248625629581793 no 829 0.262835930562094 277 11673567 SGTC_345 1362-0200 395 µM 0.633878382332604 0.248886595962829 no 830 0.263080097286214 288 1419823 SGTC_3265 9137266 49.47 µM 0.632918738368238 0.24922143935265 no 831 0.263393355220039 262 17224265 SGTC_812 4251-0442 148 µM 0.632776824989194 0.249270976747022 no 832 0.26343969636255 300 5723007 SGTC_2925 9010536 32.5 µM 0.631892164618921 0.249579901224876 no 833 0.263728671830786 264 2994177 SGTC_1680 diphenhydramine 100 µM 0.63110753774607 0.249854063984482 no 834 0.263985106441706 285 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2270 7924575 90.91 µM 0.631024099796695 0.249883228108248 no 835 0.264012383409271 308 1262135 SGTC_739 1486-1183 203 µM 0.631020080479624 0.249884633028521 no 836 0.264013697413361 285 4346692 SGTC_3120 9124077 49.47 µM 0.627832482557884 0.251000151444739 no 837 0.265056842341776 312 18774327 YGL155W CDC43 SGTC_2555 cholic acid 100 µM 0.627661294812297 0.251060134059647 no 838 0.265112922904083 286 6708657 Influences liver metabolism. SGTC_2682 pyrogallin 40.03 µM 0.626288731025213 0.251541341852245 no 839 0.265562788216919 277 822798 An ATP competetive kinase inhibitor. SGTC_726 3448-4391 34.2 µM 0.626042211481285 0.25162782084944 no 840 0.2656436273479 303 1356692 SGTC_764 1951-2361 146 µM 0.625286625910025 0.251892977890862 no 841 0.2658914780382 298 5438930 SGTC_1165 k072-0275 30.3 µM 0.625062360577131 0.251971707518919 no 842 0.26596506514012 299 6153523 YGL055W OLE1 SGTC_2214 7179297 48.276 µM 0.624804240837473 0.252062338001298 no 843 0.266049773494725 291 769744 SGTC_3025 9087895 49.47 µM 0.624374769605468 0.252213171178542 no 844 0.266190745340639 296 17173641 SGTC_2922 7999257 32.47 µM 0.624347173501329 0.252222864742625 no 845 0.266199804920661 307 2988377 SGTC_1156 4092-0367 4.88 µM 0.62388356029583 0.252385745518049 no 846 0.266352028759489 298 1357585 SGTC_26 0302-0163 425.158 µM 0.623017053905505 0.252690322949271 no 847 0.266636657534943 325 3100915 SGTC_2093 5331342 194.4 µM 0.622244767641117 0.252961945015585 no 848 0.26689046656045 298 33839 SGTC_3254 9136651 49.47 µM 0.622144301564774 0.252997291394313 no 849 0.266923493334547 319 16454030 SGTC_1094 duloxetine 25.4 µM 0.619990883175111 0.253755540102162 no 850 0.267631894589992 274 60834 A selective serotonin reuptake inhibitor. SGTC_47 0149-0135 24.25 µM 0.619775703862346 0.253831373263185 no 851 0.267702733293439 285 5239155 SGTC_3355 9151058 44.0485 µM 0.619237028754515 0.254021264467098 no 852 0.267880110754656 299 17015728 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.619016598082493 0.254098991130364 no 853 0.267952712262648 317 688798 SGTC_2866 9034245 58.44 µM 0.618018578869389 0.254451061466441 no 854 0.268281545901297 290 6462273 SGTC_1692 fluoroquinolonic acid 71 µM 0.617828238969211 0.254518236514167 no 855 0.268344283329992 304 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2110 5483698 200 µM 0.616266034893919 0.255069922830352 no 856 0.268859475919563 292 2848765 YHR062C RPP1 SGTC_2567 aureobasidin a 60 nM 0.616151392665243 0.255110432911344 no 857 0.268897302842683 328 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2289 7946404 165.07 µM 0.615804236577368 0.255233124819168 no 858 0.269011865469137 307 1246120 YPR165W RHO1 SGTC_1550 gossypolone 36.6 µM 0.615801276723643 0.255234171023325 no 859 0.269012842335714 293 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1885 st057546 99.9 µM 0.61379883557333 0.255942477072115 no 860 0.269674133410918 289 702008 SGTC_1778 st046819 58.9 µM 0.613003243480707 0.256224179359961 no 861 0.269937097542417 312 671715 SGTC_34 0469-0683 81.75 µM 0.612448930795192 0.256420545232804 no 862 0.270120388307416 287 3690923 SGTC_1423 4048-0112 5.59 µM 0.612383544598354 0.256443713533726 no 863 0.270142013215908 294 X1423 SGTC_1682 st012968 530 nM 0.608198195581316 0.257928975096888 no 864 0.271528015617215 290 24207270 SGTC_528 3492-0019 172 µM 0.608160867806878 0.257942241714913 no 865 0.2715403928407 314 2869262 SGTC_1372 2752-0194 270 µM 0.608150160261051 0.257946047335834 no 866 0.271543943323565 290 823334 SGTC_1663 st014140 55.4 µM 0.607606876441867 0.258139176704854 no 867 0.271724119509542 302 4207120 SGTC_1617 st002906 78 µM 0.607176958546961 0.258292059284792 no 868 0.271866740862869 304 5150859 SGTC_2693 st077581 40.7 µM 0.606604061382402 0.258495859454618 no 869 0.27205685215424 303 25238761 SGTC_971 1315-0384 26.7 µM 0.60626366576036 0.258616989879522 no 870 0.272169840986435 325 6769120 SGTC_1558 st069300 45.6 µM 0.605823479883119 0.258773674419762 no 871 0.272315988158465 298 24208000 SGTC_1121 fusaric acid 630.51 nM 0.605395424601942 0.258926088166729 no 872 0.272458145204789 279 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2036 5160441 105 µM 0.605201079134393 0.258995302312985 no 873 0.272522699445708 305 134534 YIL048W NEO1 SGTC_2113 5491891 107.031 µM 0.605051586467644 0.25904854910452 no 874 0.272572360443218 299 789979 SGTC_1405 3909-7894 12 µM 0.602815176532122 0.25984579624713 no 875 0.273315824723099 298 7104060 SGTC_3232 9132874 49.47 µM 0.60220468051688 0.260063648802001 no 876 0.273518950243775 292 3784940 SGTC_1422 4031-0024 15.5 µM 0.602140809682333 0.260086446241108 no 877 0.273540205799202 320 782427 SGTC_2331 7980721 200 µM 0.601750311192794 0.260225849404618 no 878 0.273670177447302 301 2981221 SGTC_3218 9131285 49.47 µM 0.601605605544245 0.260277517319929 no 879 0.273718348339994 317 17156417 SGTC_3048 9093155 49.47 µM 0.601517952000248 0.260308817050783 no 880 0.273747529264452 278 25236002 SGTC_2828 7998861 71.43 µM 0.599798894687888 0.260923057671759 no 881 0.274320135030568 255 2988188 SGTC_3257 9139206 32.98 µM 0.598300061740351 0.261459217015685 no 882 0.27481986771154 299 4910041 SGTC_1916 st067606 49.2 µM 0.5967508100056 0.262014006034068 no 883 0.275336881953176 297 19590279 SGTC_927 2425-1185 123 µM 0.595052843155124 0.262622742522349 no 884 0.275904074446128 335 730375 SGTC_1834 st055981 52.8 µM 0.593156977909513 0.263303281486248 no 885 0.27653805079862 310 471719 YDL150W RPC53 SGTC_2834 9001755 58.44 µM 0.592897466635235 0.263396505564867 no 886 0.276624886771475 321 2989575 SGTC_2096 5468907 200 µM 0.591719460610176 0.263819891711792 no 887 0.277019231412384 306 759785 SGTC_753 1322-0200 289 µM 0.591410538858907 0.263930978420614 no 888 0.277122690361015 293 5403907 SGTC_1732 st034308 51.822 µM 0.588513959751334 0.264973732269664 no 889 0.278093683315841 295 830119 SGTC_163 TUB2.036 7.546 µM 0.588185572239414 0.265092082096166 no 890 0.278203870224129 304 15992207 YJR013W GPI14 SGTC_1559 coumarin 343 70.1 µM 0.586121646943647 0.265836528466016 no 891 0.278896885194969 313 108770 A hepatotoxic, DNA x-linker. SGTC_592 k241-0073 46.5 µM 0.585772117910829 0.265962706473327 no 892 0.279014331496015 307 4230158 SGTC_1565 sinapyl alcohol 95.1 µM 0.584416427272641 0.266452390032182 no 893 0.279470088627877 314 5280507 A phenol propionate derived from cinnamic acid. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.584187741091285 0.266535037781449 no 894 0.279547004148069 285 6708739 YPR165W RHO1 SGTC_703 3875-0075 71.8 µM 0.584119617066982 0.266559660477749 no 895 0.279569918733748 332 2850814 SGTC_946 3434-1334 87.4 µM 0.581045983155649 0.267671787826313 no 896 0.28060473138116 299 4047976 SGTC_3211 9128781 49.47 µM 0.580682293478975 0.267803535556549 no 897 0.280727298753485 328 17194361 SGTC_3162 9099653 49.47 µM 0.580671277434279 0.267807526663114 no 898 0.280731011684222 283 25237511 SGTC_2647 atorvastatin 60.16 µM 0.579479368347711 0.268239531571258 no 899 0.281132881949148 296 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3069 9117009 49.47 µM 0.577939560998069 0.268798150040986 no 900 0.281652462404236 289 41904981 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.577897839374599 0.268813294132113 no 901 0.281666547060513 334 6708760 SGTC_398 bronopol 33.3 µM 0.577823587038769 0.26884024726261 no 902 0.281691614485673 300 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1243 0416-0003 5.65 µM 0.576111961428534 0.269461932570629 no 903 0.282269753486886 327 2141977 SGTC_1406 3909-7906 11.9 µM 0.574996874150023 0.269867334468775 no 904 0.282646705519818 322 X1406 SGTC_3305 9127027 53.8275 µM 0.573607514025765 0.270372878055207 no 905 0.283116712941645 322 41905295 SGTC_13 0199-0087 65 µM 0.573511063458689 0.270407990886377 no 906 0.283149355175159 311 4589825 SGTC_823 0417-1665 178 µM 0.573274276740308 0.270494202760975 no 907 0.283229499710929 330 3429856 SGTC_1221 2958-7315 257 µM 0.57277616515794 0.270675605444794 no 908 0.283398129652778 306 4562705 SGTC_1056 3448-1962 115 µM 0.572237536409221 0.270871832043521 no 909 0.283580530362249 318 715507 SGTC_2694 st077685 81.9 µM 0.571640475314061 0.271089428928744 no 910 0.283782784252111 285 2838096 SGTC_2518 prenyletin 46.28 µM 0.571253477293329 0.271230515592004 no 911 0.283913916352872 281 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1986 st071812 45 µM 0.570813413353108 0.271390992797321 no 912 0.284063064770041 315 11838594 SGTC_402 epigallocatechin gallate 10 µM 0.570419013204828 0.271534858071363 no 913 0.284196768452935 321 65064 An antioxidant. SGTC_216 k038-0035 28.382 µM 0.570032660951679 0.271675824534009 no 914 0.284327773026619 316 4444231 YPR107C YTH1 SGTC_890 0929-0006 47.2 µM 0.568936071568715 0.272076130099494 no 915 0.284699762401747 302 1378169 SGTC_2308 7584454 197.62 µM 0.567808218213589 0.27248815415148 no 916 0.285082599436788 334 893577 SGTC_3180 9109287 49.47 µM 0.567330049571524 0.272662930782158 no 917 0.285244982409988 302 18891271 SGTC_993 3909-8757 62.7 µM 0.56651298455165 0.272961706983366 no 918 0.285522554343664 303 4288324 YLR208W SEC13 SGTC_2207 7258803 200 µM 0.566476177283644 0.272975170118708 no 919 0.28553506147186 323 3666799 SGTC_465 cgp-37157 41 µM 0.565679324830448 0.273266718583934 no 920 0.285805896253364 307 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_246 cycloheximide 667 µM 0.565161662966503 0.273456200779945 no 921 0.285981904974997 306 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_530 4358-1714 28 µM 0.564840983080441 0.27357361335823 no 922 0.286090964256594 308 1564641 SGTC_964 1287-0107 19.4 µM 0.564113218585403 0.273840166949042 no 923 0.286338541283425 312 51516812 YPR165W RHO1 SGTC_1468 k284-1086 134 µM 0.563575035407235 0.274037366379728 no 924 0.286521690340506 304 15996457 SGTC_3041 9091929 49.47 µM 0.561885022761558 0.274657071434279 no 925 0.287097179351457 319 25236887 SGTC_526 4469-0568 170 µM 0.561675071897613 0.274734105847606 no 926 0.287168710755945 324 2901964 SGTC_803 4488-1585 147 µM 0.561261700618038 0.274885809675468 no 927 0.28730957325896 313 747204 SGTC_1153 4055-0057 267 µM 0.559792477501508 0.275425336256369 no 928 0.287810497635289 323 882706 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.558627600578886 0.275853471104492 no 929 0.288207949649824 325 2724278 An inhibitor of dopamine biosynthesis. SGTC_283 0987-0079 11.7 µM 0.557378591616913 0.276312890508725 no 930 0.288634394640371 310 411556 SGTC_855 0428-0020 25 µM 0.557146670660482 0.276398238636359 no 931 0.288713611349767 304 6812414 SGTC_2887 9044784 58.44 µM 0.556722684952546 0.276554301017022 no 932 0.288858457636832 301 6465546 SGTC_622 1348-1566 26.3 µM 0.555831351369695 0.276882527495342 no 933 0.289163075514922 337 7340407 SGTC_1773 st048542 73.5835 µM 0.554672398765805 0.277309587619726 no 934 0.289559379301205 321 3237138 SGTC_2482 5981709 142.65 µM 0.553824433319304 0.277622256640082 no 935 0.289849502507081 327 877755 SGTC_589 1227-0070 34.1 µM 0.553607225527078 0.277702375041796 no 936 0.289923839991006 317 2841384 SGTC_2531 methyl deoxycholate 70.07 µM 0.553490231299515 0.277745533745884 no 937 0.289963883955607 329 16667744 Haematoxylin. SGTC_846 0335-0850 148 µM 0.552739379414009 0.278022597956708 no 938 0.290220941987856 311 6819598 SGTC_2837 9008476 45.46 µM 0.552703080968907 0.278035995492849 no 939 0.290233371653342 328 2992805 SGTC_2952 9073731 13.78 µM 0.551017589292978 0.278658446910487 no 940 0.290810808491786 309 16457353 SGTC_57 miconazole 162.5 nM 0.550513813214523 0.278844622841892 no 941 0.290983502607308 313 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_454 lyso-paf C-16 6.67 µM 0.549742033581297 0.279129959746628 no 942 0.291248161061745 342 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3003 9075612 71.4286 µM 0.548778656361802 0.279486331823201 no 943 0.291578679690965 338 6501993 SGTC_1561 5-methoxyflavone 52.9 µM 0.548248779872973 0.279682437639347 no 944 0.291760545981299 319 94525 SGTC_3246 9135460 32.98 µM 0.548208133860425 0.279697483372897 no 945 0.291774498847996 342 41446951 SGTC_1411 3909-8223 150 µM 0.547590644152918 0.279926104782276 no 946 0.291986507478931 332 X1411 SGTC_2413 inermin 26.06 µM 0.547525896992355 0.279950082230861 no 947 0.292008741893272 358 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_64 000l-0018 272.079 µM 0.547429811752754 0.279985666767841 no 948 0.292041739372649 314 6811119 SGTC_2593 nobiletin 86.24 µM 0.543585490281225 0.281411182085822 no 949 0.293363373376339 299 72344 An anti-infammatory. SGTC_2738 aclarubicin 5.55 µM 0.541645730301972 0.282131792784918 no 950 0.294031291120373 285 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_375 3970-0961 9.27 µM 0.54113246081666 0.282322618242645 no 951 0.294208142798109 309 2898222 SGTC_1097 itavastatin 7.23 µM 0.540087316324207 0.282711378247935 no 952 0.294568408685133 328 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2996 9066192 71.4286 µM 0.538776022826822 0.28319950061167 no 953 0.295020704979934 306 6472854 SGTC_699 0375-0592 111 µM 0.537978317109654 0.283496640179977 no 954 0.295296009054736 298 762578 SGTC_821 1114-0266 29.2 µM 0.537400756898453 0.283711870362881 no 955 0.295495410306785 324 3123235 SGTC_2138 5575593 77.673 µM 0.53708411818356 0.283829900281732 no 956 0.295604755322904 336 762213 SGTC_266 formosanin C 406 nM 0.535691395492204 0.284349329041477 no 957 0.296085925678663 308 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2012 4023501 200 µM 0.535497025848113 0.284421857099923 no 958 0.296153106822767 350 3477460 SGTC_2402 5553605 200 µM 0.534632049262392 0.284744725920021 no 959 0.296452158637831 322 6758546 SGTC_2928 9011484 9.79 µM 0.533996391664324 0.284982108558599 no 960 0.296672015270057 329 2994751 SGTC_2183 6420625 130.508 µM 0.533684547881654 0.28509859930462 no 961 0.296779900826871 333 2897619 SGTC_2809 7964133 12.99 µM 0.533622477474933 0.285121788712265 no 962 0.296801376864054 346 1253665 SGTC_908 3448-7491 47.7 µM 0.533404705270025 0.285203155180111 no 963 0.296876730537386 289 1203031 SGTC_2427 5545055 42.75 µM 0.531706782279928 0.285837931167121 no 964 0.297464546895609 329 5372858 SGTC_122 0236-0016 402.397 µM 0.531212498070181 0.286022847670597 no 965 0.297635766584115 345 6808838 SGTC_1374 2889-5571 141 µM 0.529922912769275 0.28650556146546 no 966 0.298082689595391 323 2853281 SGTC_1512 0259-0544 12.2 µM 0.528209282819929 0.287147599829015 no 967 0.298677043587254 320 18476 SGTC_1340 1486-1359 257 µM 0.527803236311658 0.287299831288984 no 968 0.298817955344905 324 4309068 SGTC_1961 st076550 68.7 µM 0.527704743441056 0.287336763141999 no 969 0.298852140226765 334 1579337 SGTC_123 0083-0120 66.675 µM 0.526126487503125 0.287928867615329 no 970 0.299400163107094 329 16001701 SGTC_2754 granisetron 64.02 µM 0.525001340559457 0.288351333444094 no 971 0.299791129512828 351 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_784 4579-0127 173 µM 0.524682005235249 0.288471289461352 no 972 0.299902134352018 333 1948547 SGTC_2514 salinomycin 42.74 µM 0.524429939102565 0.288565992896688 no 973 0.299989768738904 347 23682228 A polyether potassium ionophore. SGTC_2960 9079389 5.97 µM 0.524089601191611 0.288693884041541 no 974 0.300108110449232 316 16457355 SGTC_1886 st057356 49.9 µM 0.522255306044184 0.28938362909522 no 975 0.300746291631462 328 24207747 SGTC_1294 1000-1494 117 µM 0.521935015233248 0.289504146537641 no 976 0.300857788795125 327 712797 YDL207W GLE1 SGTC_2101 5377231 179.231 µM 0.520629927899549 0.289995461881797 no 977 0.30131229835509 353 2844213 SGTC_863 0466-0191 129 µM 0.520485496459118 0.290049858797735 no 978 0.301362617027776 346 765160 YPR165W RHO1 SGTC_1120 ficusin 1.78878 µM 0.519854631573929 0.290287516194024 no 979 0.301582449269641 350 6199 A DNA cross-linker. SGTC_1401 3807-4679 7.6 µM 0.519663489660496 0.290359540561284 no 980 0.301649069139519 336 3291456 SGTC_1861 st057647 17.4 µM 0.518325896438816 0.290863794351445 no 981 0.302115453844824 359 688668 SGTC_3179 9107801 49.47 µM 0.516652205809843 0.291495328041595 no 982 0.302699482674114 290 4818259 SGTC_2126 5251174 33.877 µM 0.516415547543508 0.291584677889393 no 983 0.302782104594771 326 790722 SGTC_2000 st075254 36.4 µM 0.516129784162392 0.291692584289599 no 984 0.30288188350705 320 17234175 SGTC_873 0591-4978 488 µM 0.515747946364166 0.291836798154844 no 985 0.303015231328372 343 3305145 SGTC_3219 9131112 49.47 µM 0.515208793848933 0.292040483746756 no 986 0.303203562313373 315 17612988 YMR079W SEC14 SGTC_2382 9035899 200 µM 0.513851358341069 0.292553600040407 no 987 0.303677958758099 340 6462679 SGTC_354 2783-3500 4.88 µM 0.513505397352842 0.292684441700636 no 988 0.303798918132819 327 6740761 SGTC_1973 st070275 50.2 µM 0.512809139331536 0.29294784726371 no 989 0.304042418042789 327 17118334 SGTC_1681 tripelennamine 100 µM 0.512800982545961 0.29295093375817 no 990 0.304045271202693 305 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2616 abietic acid 100 µM 0.511343869838073 0.293502541233089 no 991 0.304555145630814 340 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2843 9000894 45.46 µM 0.511146559262514 0.293577272479986 no 992 0.304624217990341 283 2242070 SGTC_2662 daunorubicin 22.37 µM 0.510856470475951 0.293687159407056 no 993 0.304725781795861 312 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1420 4'-methoxyflavone 42 µM 0.510787189490269 0.293713406169592 no 994 0.304750040184658 334 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3204 9114183 49.47 µM 0.509803001703129 0.294086378088404 no 995 0.305094741267211 315 17027248 SGTC_324 1315-0088 19.6 µM 0.508781799447591 0.294473608408695 no 996 0.305452589137961 357 6787421 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.508700501488028 0.294504445943446 no 997 0.305481085419491 330 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1705 st027868 56.3335 µM 0.508463658543369 0.294594292516987 no 998 0.305564109512236 354 292948 SGTC_2585 alliin 100 µM 0.508010124675163 0.294766376261844 no 999 0.305723121411893 355 87310 A garlic compound which reacts with lipids. SGTC_2831 7999036 19.48 µM 0.507610577668382 0.294918014234268 no 1000 0.305863235528303 362 2988270 SGTC_1036 k216-0215 33.5 µM 0.506164023661656 0.295467317707118 no 1001 0.306370754196102 305 622330 SGTC_2435 5706476 10.6 µM 0.505854383139296 0.295584959371696 no 1002 0.306479438873967 315 5725375 SGTC_1967 st070177 51.4 µM 0.504987930728782 0.295914264852024 no 1003 0.306783656511045 353 5729214 SGTC_3122 9126309 49.47 µM 0.504045392393281 0.296272678873571 no 1004 0.307114739644089 359 17591206 SGTC_1956 st077085 54 µM 0.503466589223556 0.296492875886925 no 1005 0.307318132402108 351 24208685 SGTC_2747 doxorubicin 7.63 µM 0.503198441255806 0.29659491418636 no 1006 0.307412380307369 305 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1183 1254-0324 198 µM 0.502859124001295 0.296724057574117 no 1007 0.307531660824859 312 5799357 SGTC_2338 7999974 200 µM 0.502574199335174 0.296832519147116 no 1008 0.307631836386112 351 315925 SGTC_2678 equilin 100 µM 0.502311450801692 0.296932555065347 no 1009 0.307724227841178 310 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2465 5809242 33.21 µM 0.501003363499872 0.297430810885527 no 1010 0.308184377881388 358 2731748 SGTC_2186 6124449 200 µM 0.500963059958216 0.297446168731952 no 1011 0.308198560380178 338 3834182 YLR033W RSC58 SGTC_38 0929-0051 58.268 µM 0.500893776589656 0.297472570318533 no 1012 0.30822294132097 362 1379719 SGTC_2811 7967822 32.47 µM 0.498682166417567 0.298315903026669 no 1013 0.3090016549927 319 2232244 SGTC_2917 7979103 53.79 µM 0.498087912160342 0.298542689852863 no 1014 0.30921104004288 342 2980565 SGTC_646 4092-0839 27.3 µM 0.497533401775231 0.298754379824657 no 1015 0.30940647727557 363 877796 SGTC_3262 9137218 49.47 µM 0.497408613056812 0.298802028588446 no 1016 0.309450466505044 305 17650664 SGTC_2477 5967686 25.23 µM 0.496695894566866 0.299074235981695 no 1017 0.309701758979347 348 776118 SGTC_3329 9141233 27.5565 µM 0.496417952199236 0.299180420554718 no 1018 0.309799780872849 333 4909101 YNL103W MET4 SGTC_2303 7774051 200 µM 0.495563254805407 0.299507054668594 no 1019 0.310101291597166 360 2953184 SGTC_3307 9126885 69.2785 µM 0.494865337514403 0.299773892981294 no 1020 0.31034758990959 334 24824909 SGTC_1350 1495-0454 146 µM 0.493414834400493 0.300328815388674 no 1021 0.310859751375591 352 1069057 SGTC_2294 7971431 200 µM 0.491886540313217 0.30091400019059 no 1022 0.311399776929191 379 5741572 SGTC_326 k292-0812 17.5 µM 0.490833727597989 0.301317421730918 no 1023 0.311772026559774 355 3579357 SGTC_2583 asiatic acid 100 µM 0.48980198922677 0.301713004009368 no 1024 0.312137011476834 357 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1445 4239-0156 97.7 µM 0.488376536351433 0.30225992550517 no 1025 0.312641579214829 377 4008346 SGTC_2879 9041815 71.43 µM 0.487911890532805 0.302438298121586 no 1026 0.31280612592929 325 4942971 SGTC_2766 oltipraz 83.91 µM 0.486810913182938 0.302861139991282 no 1027 0.313196167928832 329 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1025 k007-0731 70 µM 0.4864902105272 0.302984358961363 no 1028 0.313309822238099 331 6256118 SGTC_2143 5623677 140.463 µM 0.48588415699541 0.303217275429563 no 1029 0.313524650899078 336 5375313 SGTC_1909 st060837 51.5 µM 0.485738084601829 0.303273425454796 no 1030 0.313576438853849 370 678937 SGTC_2380 9035439 200 µM 0.485521796096497 0.303356574991351 no 1031 0.313653127712199 340 6462575 SGTC_98 0074-0023 107.663 µM 0.484365952348866 0.303801097921154 no 1032 0.314063088705686 346 3563821 SGTC_409 arachidonic acid 100 µM 0.48415955277712 0.303880507164811 no 1033 0.314136319807391 342 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_421 streptovitacin 30 mM 0.483159560425677 0.304265370734713 no 1034 0.314491223257843 344 91467 include heat shock SGTC_425 3825-7017 13.1 µM 0.480396197457797 0.305330023571333 no 1035 0.315472848829213 379 3397440 SGTC_3082 9117008 49.47 µM 0.479518501353468 0.305668522817671 no 1036 0.315784904724884 344 41448529 SGTC_3288 9119690 36.221 µM 0.477421619318215 0.306477895183013 no 1037 0.316530961200175 374 17595618 YKL019W RAM2 SGTC_1903 st060211 78.3 µM 0.476355824568159 0.306889642184837 no 1038 0.316910450365931 327 688960 SGTC_952 1185-0122 232 µM 0.474067321252253 0.307774579534951 no 1039 0.317725950500747 331 678600 SGTC_401 neomycin 50 µM 0.472162817355466 0.308511882584346 no 1040 0.31840528880817 330 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3176 9106582 49.47 µM 0.469824646491025 0.309418130760516 no 1041 0.319240152077882 329 17018027 SGTC_333 3486-0131 40.1 µM 0.468778488110917 0.309823985812854 no 1042 0.319613988937822 356 6744690 SGTC_1124 fisetin 1.16336 µM 0.468088070965682 0.310091958830668 no 1043 0.319860804798638 353 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1737 st035557 69.7 µM 0.467947152975612 0.310146666020826 no 1044 0.319911191098705 349 5716916 SGTC_1859 st055998 20 µM 0.466757910469816 0.310608521098839 no 1045 0.320336546075555 346 676301 SGTC_2900 5328528 85.29 µM 0.466563234257121 0.310684154159815 no 1046 0.320406198196514 338 795359 SGTC_540 1187-0821 17.3 µM 0.465208689033264 0.311210625774669 no 1047 0.320891008453237 365 847520 SGTC_2235 salicylic acid 500 µM 0.464969991457387 0.311303440534344 no 1048 0.32097647327035 334 338 A COX inhibitor and kinase inhibitor. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.463502666634084 0.311874255994689 no 1049 0.321502051941089 367 23665772 A membrane-active detergent. SGTC_1283 0922-0125 16.4 µM 0.462118891970756 0.312412983311691 no 1050 0.321998031544036 357 3360884 SGTC_2553 4-methylesculetin 85.09 µM 0.461990925087193 0.312462823307272 no 1051 0.32204391412775 347 5319502 SGTC_2898 9056270 58.44 µM 0.461669546701621 0.31258800751432 no 1052 0.322159156452162 340 19154699 SGTC_279 1273-0055 2.93 µM 0.461185261897651 0.312776688328802 no 1053 0.322332847304101 372 2847562 SGTC_682 0kpi-0099 17 µM 0.460437462156296 0.31306813280651 no 1054 0.322601125130557 360 1714895 YML126C ERG13 SGTC_1225 1216-0074 20.6 µM 0.458227330791162 0.313930182952149 no 1055 0.32339456314079 347 4241466 SGTC_1328 1441-0025 69.2 µM 0.457920852783622 0.314049803449072 no 1056 0.323504652404632 347 4562601 SGTC_1658 st012944 20 µM 0.457345052878325 0.314274594988871 no 1057 0.323711525949 355 24207260 SGTC_3268 9137683 49.47 µM 0.455508314336748 0.31499211546511 no 1058 0.324371793704443 381 1953228 SGTC_247 mechlorethamine 29.705 µM 0.455217115398582 0.315105936344133 no 1059 0.324476524220038 352 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.45399561845725 0.315583573831624 no 1060 0.324915990209588 351 390807 SGTC_484 loperamide 105 µM 0.45226955570149 0.316259035269263 no 1061 0.32553740265667 337 3955 An opioid-receptor agonist. SGTC_1815 st051655 58.2 µM 0.45183703611363 0.316428389712615 no 1062 0.325693193285766 345 5984156 SGTC_2416 tofa 880 nM 0.45122126756583 0.316669562300526 no 1063 0.325915041477197 326 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2087 5276107 200 µM 0.4507628405919 0.316849160940649 no 1064 0.32608024291273 351 144405 SGTC_455 paf C-16 10 µM 0.448941837756874 0.317563004022716 no 1065 0.326736807079479 355 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2789 5281112 71.43 µM 0.448043569487279 0.317915380315943 no 1066 0.32706087636989 334 765948 SGTC_3160 9100216 49.47 µM 0.447945878302885 0.317953712956895 no 1067 0.327096128401212 355 17191039 SGTC_323 4013-0906 34.3 µM 0.443512308866564 0.319695430702771 no 1068 0.328697609038306 349 2910086 SGTC_1652 st011932 78 µM 0.442048490168088 0.320271365303923 no 1069 0.329227058651308 362 1551076 SGTC_1610 st001799 48.1 µM 0.441914323317876 0.320324174499057 no 1070 0.329275602712342 355 621897 SGTC_1881 5652484 16 µM 0.441709348616625 0.320404861283169 no 1071 0.329349771927882 368 2255129 SGTC_1315 1237-0019 3.69 µM 0.440492105675255 0.320884194827519 no 1072 0.329790364328995 358 825140 SGTC_362 0310-0100 9.03 µM 0.439481555256088 0.321282362685499 no 1073 0.330156321994194 322 790235 SGTC_2473 5854593 8.94 µM 0.437341295230984 0.322126326504331 no 1074 0.330931925645765 366 2872951 SGTC_2236 dapsone 200 µM 0.436820838943497 0.322331695763769 no 1075 0.331120642436744 340 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1072 oxiconazole 14.9 nM 0.43637380309273 0.322508137019009 no 1076 0.331282771328037 330 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_497 capsazepine 133 µM 0.43575864642779 0.322750999493522 no 1077 0.331505925202371 337 2733484 A calcium channel blocker. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.434538546944913 0.323232915704662 no 1078 0.331948704720168 347 94937 An inhibitor of serotonin biosynthesis. SGTC_2288 7946289 167.31 µM 0.433974972652406 0.323455617145107 no 1079 0.332153307646336 388 1246052 SGTC_2847 9005661 71.43 µM 0.433457529401261 0.323660145198287 no 1080 0.332341206991998 349 2991449 SGTC_1054 3429-0080 167 µM 0.43344835749269 0.323663771028433 no 1081 0.332344537970604 371 1162877 SGTC_3293 9120939 62.045 µM 0.43270265009617 0.323958619342899 no 1082 0.332615402158984 380 934087 SGTC_1726 st035556 14.5795 µM 0.431978803728198 0.324244929615821 no 1083 0.332878409348378 333 5919439 SGTC_1712 st032288 53.4 µM 0.431714317021288 0.324349570658542 no 1084 0.332974530244251 357 2883011 SGTC_1957 st077035 62.4 µM 0.431551675013602 0.324413924937528 no 1085 0.333033643752122 367 705593 SGTC_1981 st071826 47 µM 0.429526885126255 0.32521553344271 no 1086 0.333769916408098 350 11838600 SGTC_2284 7945075 39.21 µM 0.427736280421024 0.325925103413805 no 1087 0.334421566342171 388 1245402 SGTC_2520 obtusaquinone 4.71 µM 0.426662960697696 0.326350734663478 no 1088 0.334812416140745 393 5967872 SGTC_219 mitoxanthrone 164.414 µM 0.426220999803076 0.326526062645006 no 1089 0.334973408431983 364 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3330 9141424 71.43 µM 0.42608734836404 0.32657909035375 no 1090 0.335022099372472 347 27261020 SGTC_1988 st071872 53.4 µM 0.426079617967227 0.326582157582675 no 1091 0.335024915740425 352 16414116 SGTC_3225 9130819 49.47 µM 0.425564829243527 0.32678643930208 no 1092 0.335212486422595 365 4547121 SGTC_1250 0485-0349 40.2 µM 0.425490358780105 0.326815995443823 no 1093 0.33523962421154 361 6842794 YDL195W SEC31 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.42546119496938 0.326827570392279 no 1094 0.335250252033017 391 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1945 st075991 56.6 µM 0.42536441737481 0.326865982055996 no 1095 0.335285520488254 327 1084980 SGTC_2217 6934799 96.0675 µM 0.424623130810355 0.327160264392631 no 1096 0.335555714123956 367 675606 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.424588848443853 0.327173876703995 no 1097 0.335568211859475 388 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3261 9137475 49.47 µM 0.422318383290605 0.328075908876863 no 1098 0.336396320878271 354 17027690 SGTC_1436 4092-1007 8.32 µM 0.42198228441142 0.328209522867541 no 1099 0.336518974145711 341 2881121 SGTC_1318 1280-3875 124 µM 0.421799485373109 0.328282202702853 no 1100 0.336585690686125 367 373245 SGTC_886 0866-0150 153 µM 0.419314600324641 0.329270822313719 no 1101 0.33749311378333 377 271463 SGTC_1058 3448-5425 97.3 µM 0.419029495635559 0.329384328686913 no 1102 0.337597288067308 373 7279705 SGTC_3064 1327-0027 10 µM 0.417581813444521 0.329960924881984 no 1103 0.338126447965908 376 16000455 YPR107C YTH1 SGTC_359 0081-0058 15.9 µM 0.417138221468751 0.330137683746576 no 1104 0.338288654744824 429 3494159 SGTC_1826 st055655 41.6 µM 0.416981544098763 0.3302001243143 no 1105 0.338345953604112 365 676168 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.415729781866868 0.330699158304994 no 1106 0.338803872926577 375 688751 SGTC_974 1326-0144 138 µM 0.415696546068538 0.330712412366796 no 1107 0.338816034488396 380 5411856 SGTC_2935 9038016 29.96 µM 0.413670253259049 0.331520875513265 no 1108 0.339557807561082 366 6463195 SGTC_549 1661-1316 519 µM 0.413629419404614 0.331537175750583 no 1109 0.339572762175009 380 2857282 SGTC_1926 methyl fluorone black 53.6 µM 0.413246524934736 0.331690036765175 no 1110 0.339713002197216 344 72721 Reacts with homocysteine. SGTC_1520 flindersine 88 µM 0.412097407545775 0.332148961274049 no 1111 0.340134014385523 383 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2128 5255449 168.493 µM 0.411835032750883 0.332253781579808 no 1112 0.34023017091486 333 736008 SGTC_1769 st044406 64.4 µM 0.411533046971736 0.33237444295675 no 1113 0.340340857153152 388 670903 SGTC_3133 9127736 49.47 µM 0.410977299015511 0.332596542900146 no 1114 0.340544590277372 372 27243420 SGTC_3228 9131799 49.47 µM 0.41085790786565 0.332644264229826 no 1115 0.340588364271704 379 17015818 SGTC_1098 clofazimine 15.1 µM 0.410489708112344 0.332791452865991 no 1116 0.340723375854414 377 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3039 9090270 49.47 µM 0.410205297126928 0.332905164408212 no 1117 0.340827677720291 355 17173750 SGTC_435 c-PAF 6.7 µM 0.409722974222562 0.333098039068166 no 1118 0.341004587516774 385 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_138 0850-0259 40.9225 µM 0.409602327149639 0.333146291170241 no 1119 0.341048844769148 362 6813004 SGTC_365 0121-0052 13.6 µM 0.409266442497054 0.333280640850209 no 1120 0.341172069653033 343 3101739 SGTC_126 0417-1624 672.48 µM 0.4074482319849 0.334008273398613 no 1121 0.341839404244072 415 41912 YDL195W SEC31 SGTC_1653 st012112 65 µM 0.404943838468654 0.335011532670628 no 1122 0.342759396740531 375 720429 SGTC_536 3852-0578 10.6 µM 0.404867474202931 0.335042142721286 no 1123 0.342787463951678 369 2869208 SGTC_1061 3448-9325 110 µM 0.404275411842391 0.335279503701676 no 1124 0.343005102226843 403 723482 SGTC_621 3584-0052 32.1 µM 0.403498662916096 0.335591006265797 no 1125 0.343290709084689 395 2273927 SGTC_1567 st069303 68.4 µM 0.403353933121586 0.335649060301965 no 1126 0.343343935435778 395 5581319 SGTC_3351 9150312 21.596 µM 0.401163430311129 0.336528193438357 no 1127 0.344149901522813 365 4904905 SGTC_2153 5569715 200 µM 0.400564089331109 0.336768888082562 no 1128 0.344370544578291 403 2054701 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.399212149568245 0.337312070963824 no 1129 0.344868445871163 374 23847180 SGTC_2105 5350118 200 µM 0.397784670897883 0.337885972137221 no 1130 0.345394458858591 373 2133313 SGTC_2393 9031399 185.94 µM 0.397702290115671 0.337919103891799 no 1131 0.34542482455952 386 1526623 YDL150W RPC53 SGTC_1082 camptothecin 424.86 nM 0.397356474690758 0.338058197013112 no 1132 0.345552303583897 403 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2222 6885208 172.143 µM 0.395041601332675 0.338989848868769 no 1133 0.346406093103972 374 609514 SGTC_2643 anethole 100 µM 0.393142270402547 0.339754996538461 no 1134 0.347107202599566 412 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2367 9070478 135.38 µM 0.390480452287652 0.340828424489734 no 1135 0.348090653600616 377 572802 SGTC_1273 0849-0096 14.1 µM 0.389682584644242 0.341150431240182 no 1136 0.348385637970676 394 5286025 SGTC_3032 9089427 49.47 µM 0.389300628300943 0.341304623747192 no 1137 0.348526885788856 380 17173707 SGTC_3042 9091578 49.47 µM 0.387580746782286 0.341999253162366 no 1138 0.349163159580815 369 25236497 SGTC_2832 7992762 51.95 µM 0.386333233261086 0.342503436594742 no 1139 0.349624945415262 330 2985177 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.38456539911345 0.343218388652975 no 1140 0.350279716836257 381 229346 A bile salt which induces apoptosis. SGTC_297 0986-0032 24 µM 0.384490121279635 0.343248845191432 no 1141 0.350307608180185 384 2847425 SGTC_3010 9080089 71.4286 µM 0.383802195257665 0.343527219224336 no 1142 0.350562530436245 383 17027233 SGTC_1312 1218-2183 165 µM 0.383244790958327 0.343752839004132 no 1143 0.350769135103888 372 6744073 SGTC_411 enrofloxacin 100 µM 0.382978889724978 0.343860487099216 no 1144 0.350867708268443 405 71188 A bacterial gyrase inhibitor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.382976698983331 0.343861374056925 no 1145 0.350868520447548 377 688788 SGTC_942 3253-1115 227 µM 0.382741271294684 0.343956695827601 no 1146 0.350955805111373 405 46497897 SGTC_818 4072-2707 53.5 µM 0.380753350041321 0.344761975585702 no 1147 0.351693138830334 375 882871 SGTC_2523 spermine 47.74 µM 0.378715152653031 0.345588352365472 no 1148 0.352449699956206 368 1103 A DNA binding polyamine. SGTC_1925 st057770 10.1 µM 0.378181847885441 0.345804699784225 no 1149 0.352647754581966 359 5989122 SGTC_1915 st067105 30.6 µM 0.377161319115353 0.346218841231898 no 1150 0.353026862038397 391 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1332 1480-0653 17.5 µM 0.376396927748953 0.3465291599226 no 1151 0.353310914830812 401 5749438 SGTC_506 n9-isopropylolomoucine 153 µM 0.376325653877096 0.346558100111766 no 1152 0.353337404832384 397 6610355 SGTC_835 0312-0010 67.2 µM 0.376180065275493 0.346617217989245 no 1153 0.353391517223786 368 1626196 SGTC_798 1287-0182 476 µM 0.37564313041194 0.346835278669954 no 1154 0.353591110860267 405 1649755 SGTC_1260 0700-1617 7.75 µM 0.375109034814944 0.347052236607767 no 1155 0.353789689004905 372 2853078 SGTC_1662 st014054 52 µM 0.374527411695314 0.347288558001278 no 1156 0.354005983261931 395 2838777 SGTC_1030 k029-0042 36.7 µM 0.370128133894852 0.349077962053885 no 1157 0.35564351026396 368 6080581 SGTC_2116 5511452 16.8835 µM 0.368656529656147 0.349677288527996 no 1158 0.356191877085317 402 870744 SGTC_1857 st056007 79.3 µM 0.367716954944175 0.350060136481443 no 1159 0.356542148398675 370 619834 SGTC_3278 9139605 49.47 µM 0.367346923407426 0.350210954878754 no 1160 0.356680128548804 388 7958859 SGTC_3013 9080133 71.4286 µM 0.367279407556934 0.350238475710563 no 1161 0.356705306392221 371 17050193 SGTC_2614 arthonioic acid 13.39 µM 0.367177013939619 0.350280214929134 no 1162 0.356743491957304 369 6710684 SGTC_2915 7971052 15.16 µM 0.367016429493815 0.350345678405737 no 1163 0.35680338147006 391 5741558 SGTC_3230 9131665 49.47 µM 0.366717647877533 0.350467490845422 no 1164 0.356914820617355 403 15943720 SGTC_2424 5537928 59.2 µM 0.365293107634424 0.351048483248573 no 1165 0.357446311386206 392 5382802 SGTC_510 ag-490 170 µM 0.364690539898653 0.351294342744459 no 1166 0.35767121052317 376 5328779 SGTC_2658 polymyxin b sulfate 77.05 µM 0.364604756439886 0.351329349147587 no 1167 0.357703231900218 376 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1872 amphotericin b 148 nM 0.364301298030068 0.351453194184418 no 1168 0.357816515343405 413 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_797 k781-0471 270 µM 0.364163254966776 0.351509536443113 no 1169 0.357868052064255 399 23738129 SGTC_3055 9094636 49.47 µM 0.362558055200637 0.352164937776027 no 1170 0.35846752413361 381 25236176 SGTC_2588 indole-3-carbinol 100 µM 0.362352667535458 0.352248829082482 no 1171 0.358544252675569 419 3712 Induces cell cycle arrest. SGTC_1431 4049-0260 9.09 µM 0.360705244839526 0.352921984430236 no 1172 0.359159901751112 384 3854841 SGTC_973 1325-0077 65.9 µM 0.36037951219274 0.35305513704379 no 1173 0.359281672844988 415 2835149 SGTC_2067 5224629 34.075 µM 0.36035883548082 0.353063589853673 no 1174 0.359289403058899 372 2835000 SGTC_3136 9095672 49.47 µM 0.359751758219032 0.353311800331606 no 1175 0.359516391163314 372 17217380 SGTC_1774 st048371 48.465 µM 0.359576179279923 0.353383599427241 no 1176 0.35958204992929 377 4242727 SGTC_3297 9117502 71.43 µM 0.359055916365849 0.353596379985519 no 1177 0.359776629607086 360 7453720 SGTC_1498 4478-3555 97.6 µM 0.358196774569916 0.353947857602983 no 1178 0.360098030422851 396 3437919 SGTC_3086 9117350 49.47 µM 0.357778231124673 0.354119130164522 no 1179 0.360254641361293 377 2679265 SGTC_996 3970-0799 1.8 µM 0.355339087581693 0.355117840662689 no 1180 0.361167787983279 399 6615648 YGL040C HEM2 SGTC_1482 3346-2049 8.48 µM 0.354783761298596 0.355345359189596 no 1181 0.361375797324098 385 3826804 SGTC_3186 9110464 49.47 µM 0.35469094640006 0.35538339071072 no 1182 0.361410567129276 399 17018021 SGTC_1714 st033236 13.627 µM 0.35402474821784 0.355656412087954 no 1183 0.361660168194904 384 2916566 SGTC_2238 6671620 73.2395 µM 0.350379926700286 0.357151440923474 no 1184 0.363026794479238 347 729941 SGTC_1795 st049545 62.3 µM 0.349221925088279 0.357626889489502 no 1185 0.363461353653202 372 5291882 SGTC_330 1488-0319 80.1 µM 0.348976456472224 0.357727701617793 no 1186 0.363553492389492 385 6846614 SGTC_2975 9084847 53.72 µM 0.348506655591343 0.35792067300438 no 1187 0.363729858158148 361 27211724 SGTC_972 1319-0219 195 µM 0.34828858994863 0.358010256122439 no 1188 0.363811730984408 409 23903702 SGTC_3045 9092950 49.47 µM 0.347627478013472 0.358281893985091 no 1189 0.364059983695019 391 44120432 SGTC_775 4577-0580 57.3 µM 0.347372266718952 0.358386774475484 no 1190 0.364155832805754 399 2006902 SGTC_3040 9091894 49.47 µM 0.346465216251544 0.358759618288593 no 1191 0.36449656036816 377 25236966 SGTC_1384 3089-0840 101 µM 0.346183137095123 0.358875594609734 no 1192 0.364602543396817 364 1069836 SGTC_1331 1472-0049 76.2 µM 0.346159703190801 0.358885230001451 no 1193 0.36461134846968 391 24051409 SGTC_1828 st055811 49 µM 0.346107894769706 0.358906532550646 no 1194 0.364630815258356 417 5877589 SGTC_2336 9001819 198.65 µM 0.34543089847937 0.359184939706995 no 1195 0.364885225733244 429 2989602 SGTC_1081 sertraline 6 µM 0.345379173265768 0.359206214200252 no 1196 0.364904666155125 401 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_382 3229-0966 23.2 µM 0.3443476029652 0.359630588421525 no 1197 0.365292444357734 406 5722370 SGTC_926 2268-1401 59.4 µM 0.343444700689137 0.360002172467087 no 1198 0.365631967965474 413 2931578 SGTC_1492 4158-0558 28.5 µM 0.343009593534229 0.36018128549452 no 1199 0.36579562146034 386 3967268 SGTC_1317 1273-0028 910 nM 0.34300441703555 0.360183416598932 no 1200 0.365797568603907 405 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3062 9077494 49.47 µM 0.342924890709674 0.360216157210148 no 1201 0.365827482921038 365 16459633 SGTC_2999 9069765 71.4286 µM 0.342782949656228 0.360274596216533 no 1202 0.36588087694963 406 2097066 SGTC_1119 parthenolide 318.541 nM 0.342671956944525 0.360320295656572 no 1203 0.365922630936956 413 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_598 3937-0236 20.2 µM 0.342288202728773 0.360478315575202 no 1204 0.366067006422356 403 1379313 SGTC_1157 4092-0394 27.6 µM 0.342264666797292 0.36048800783025 no 1205 0.366075861695707 370 3659885 SGTC_343 4130-2827 29.8 µM 0.34025696964665 0.361315120409823 no 1206 0.366831509570371 369 1118244 SGTC_800 3448-7362 155 µM 0.338904173445969 0.361872798982379 no 1207 0.367340960178515 398 15991913 SGTC_2099 5377090 177.372 µM 0.338203489335931 0.362161765399087 no 1208 0.36760492326202 401 2243829 SGTC_1917 st066507 28.5 µM 0.337432045672906 0.362480004364648 no 1209 0.367895615373032 387 3156428 SGTC_1667 st014849 34.6 µM 0.336326911347621 0.362936064272773 no 1210 0.368312179200909 390 5348460 SGTC_2037 5169046 200 µM 0.335804121722188 0.363151873612535 no 1211 0.368509290901929 375 5718022 SGTC_2941 9056145 11.23 µM 0.334489160045158 0.363694886253667 no 1212 0.369005234679505 435 2119517 SGTC_1461 k072-0203 53.8 µM 0.33426028290439 0.36378942895001 no 1213 0.369091579048759 396 5418714 SGTC_1766 st045414 44.774 µM 0.333786033200887 0.363985354527544 no 1214 0.369270511739732 400 253960 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.333689146581705 0.364025385427054 no 1215 0.369307070195135 410 5282309 SGTC_705 1124-0212 310 µM 0.333594440140245 0.364064516970908 no 1216 0.369342807141322 436 9554485 SGTC_2161 5662504 8.5105 µM 0.333528260331271 0.364091862500276 no 1217 0.369367780392407 367 2859334 SGTC_628 1636-0253 16 µM 0.333095876890775 0.364270540573271 no 1218 0.369530955806239 400 4456143 SGTC_1216 1165-0504 9.65 µM 0.332628289668815 0.364463799455436 no 1219 0.369707443081302 419 6304004 SGTC_276 colchicine 750 µM 0.331663092492717 0.364862834868126 no 1220 0.37007183626521 425 2833 A microtubule depolymerizer. SGTC_3015 9080845 49.47 µM 0.331265243237469 0.365027357830328 no 1221 0.370222071213634 410 5296973 SGTC_379 3970-0972 5.9 µM 0.33087527654402 0.365188645227347 no 1222 0.370369348783504 381 2898042 YBL034C STU1 SGTC_2450 5739737 12.93 µM 0.330461661910665 0.365359739303641 no 1223 0.370525578168705 395 2262825 SGTC_3091 9116372 49.47 µM 0.329497491823958 0.365758677809681 no 1224 0.370889844722119 376 17169793 SGTC_1501 4491-0275 38.4 µM 0.329223108283793 0.365872234299393 no 1225 0.370993528873239 425 5104718 SGTC_2600 tangeritin 87.95 µM 0.328889915575559 0.36601014537644 no 1226 0.371119448446368 400 68077 A bioactive flavone. SGTC_403 arphamenine a 50 µM 0.32765641983578 0.366520849507821 no 1227 0.371585728886564 436 5487158 An arginine aminopeptidase inhibitor. SGTC_3081 9117243 49.47 µM 0.327173772761637 0.366720744240813 no 1228 0.37176822827586 413 45595589 SGTC_2359 9039622 200 µM 0.327100069455631 0.366751272632644 no 1229 0.371796099641477 409 6463596 SGTC_2874 9043904 71.43 µM 0.326608967609577 0.366954711742853 no 1230 0.371981830021395 397 4463428 SGTC_146 3448-8650 53.125 µM 0.326062600619672 0.367181088370076 no 1231 0.372188496199699 437 2891488 YIL048W NEO1 SGTC_230 MPP+ 141.667 µM 0.325554911743287 0.367391480861368 no 1232 0.372380565183147 404 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1755 st041960 45.185 µM 0.325151281810083 0.367558778465392 no 1233 0.37253328921711 421 2257073 SGTC_1765 st044815 90.4 µM 0.324632748074067 0.367773738588387 no 1234 0.372729519549846 399 645695 SGTC_466 geldanamycin 89.2 µM 0.32208449702182 0.368830726543333 no 1235 0.373694341296815 404 5288382 HSP90 inhibitor. SGTC_2640 pentamidine 10.38 µM 0.321326711376845 0.369145240025438 no 1236 0.373981408042717 400 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3067 9117431 49.47 µM 0.321177121930234 0.369207336411665 no 1237 0.374038084255098 417 17150885 SGTC_721 1187-1332 279 µM 0.321098805367884 0.369239847924019 no 1238 0.374067757796166 408 25730 SGTC_2176 5809774 33.9695 µM 0.319082661240782 0.370077130107964 no 1239 0.374831915658765 427 2870539 SGTC_62 0180-0423 3.232 µM 0.318721123786894 0.370227337844332 no 1240 0.374968997468163 410 30102 YGL099W LSG1 SGTC_1308 1187-1617 41.4 µM 0.315045677954244 0.37175549274863 no 1241 0.376363486211525 412 2882570 SGTC_2691 st077356 60.2 µM 0.314918954358848 0.371808217339682 no 1242 0.376411594902044 413 2839272 SGTC_1104 tacrolimus 29.8 µM 0.314294651219528 0.372067999848325 no 1243 0.376648630132685 409 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_329 k048-0121 21.3 µM 0.312873233178175 0.372659691702149 no 1244 0.377188487094781 402 6832902 SGTC_2173 5763948 167 µM 0.312854621660173 0.372667441091582 no 1245 0.3771955573755 430 2867177 SGTC_1353 1498-1206 8.11 µM 0.311705421413136 0.373146040224419 no 1246 0.377632203705218 420 6756808 SGTC_980 1473-0395 201 µM 0.310336109724382 0.373716563195933 no 1247 0.378152687062739 416 768876 SGTC_2854 9024559 71.43 µM 0.309354234374662 0.374125831532014 no 1248 0.37852603984901 401 3163529 SGTC_83 0170-0301 39.027 µM 0.3091221787959 0.374222578410546 no 1249 0.378614294309397 407 3089716 SGTC_2250 alverine citrate 130 µM 0.307784296901837 0.374780512451998 no 1250 0.379123235599163 397 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_948 3448-0295 75.3 µM 0.304851294228812 0.376004572379495 no 1251 0.380239706297127 392 678569 SGTC_2929 9013348 24.6 µM 0.304800881010265 0.37602562279207 no 1252 0.380258905243638 403 2995952 SGTC_2263 7948595 193.29 µM 0.304781920732621 0.37603353989181 no 1253 0.380266125992789 411 2971371 SGTC_2871 9038510 12.99 µM 0.30474691159614 0.376048158529267 no 1254 0.38027945882875 433 4945164 SGTC_3187 9109394 49.47 µM 0.303915133609043 0.376395533300859 no 1255 0.380596273927107 403 17098090 SGTC_580 1123-0028 41 µM 0.302736330326055 0.376888007430404 no 1256 0.381045404296356 428 1677248 YPR107C YTH1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.302515810160746 0.376980157437175 no 1257 0.381129441477965 417 4213774 SGTC_1341 1486-1360 280 µM 0.301123622512527 0.377562080322433 no 1258 0.381660114184522 432 3976547 SGTC_192 3455-0609 60.9 µM 0.300981274842695 0.377621596157559 no 1259 0.381714386682835 391 3769639 SGTC_2683 piperine 63.03 µM 0.300768594782402 0.377710523514311 no 1260 0.381795478947309 429 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3349 9149703 23.001 µM 0.298806428456704 0.378531264187529 no 1261 0.382543872855664 399 4910494 SGTC_916 4466-0038 42 nM 0.298703989103386 0.378574127909553 no 1262 0.382582956539142 432 5722064 YGL116W CDC20 SGTC_1897 st060201 15 µM 0.298152671726235 0.378804841408906 no 1263 0.382793321170848 403 611878 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.297879933225926 0.378918992102146 no 1264 0.382897402027773 432 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1618 st003135 44.5 µM 0.297829343240759 0.378940166958866 no 1265 0.382916708809308 438 1270615 SGTC_2453 5731132 22.18 µM 0.297359450192346 0.37913686193271 no 1266 0.383096049152323 419 1362040 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.295771681772719 0.379801725437668 no 1267 0.383702225291917 402 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3044 9093193 49.47 µM 0.295250746831146 0.380019939723119 no 1268 0.383901169252374 432 25236277 SGTC_148 3253-0744 288.01 µM 0.294374548306401 0.380387056401003 no 1269 0.384235856625207 396 6893655 SGTC_281 1672-3440 14.9 µM 0.293298629591183 0.380838000827262 no 1270 0.384646950521532 433 6833000 SGTC_2076 5212012 200 µM 0.292848733641123 0.381026611508458 no 1271 0.384818888135511 415 604802 SGTC_1556 plumbagin 1.48 µM 0.291773531495796 0.381477484857416 no 1272 0.385229891947218 422 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2325 6158266 200 µM 0.291143722032204 0.381741662796183 no 1273 0.385470701099617 401 3623240 SGTC_2568 diosmetin 100 µM 0.290295159406498 0.382097685356415 no 1274 0.385795220860996 439 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1290 0986-0249 10.2 µM 0.289782742163973 0.38231272321784 no 1275 0.385991225706378 424 53329 SGTC_929 2805-0021 398 µM 0.288014907282612 0.383054880178147 no 1276 0.386667663796142 420 3098024 SGTC_3171 9103192 49.47 µM 0.287629355633954 0.383216796236869 no 1277 0.386815235743246 440 13018434 SGTC_2285 7945142 200 µM 0.287565256009231 0.383243717458859 no 1278 0.386839771803212 429 2970608 SGTC_1040 k898-0338 155 µM 0.285750012809016 0.384006335647491 no 1279 0.387534798163578 431 20969351 SGTC_587 k089-0003 57 µM 0.285365617431903 0.38416788520845 no 1280 0.387682023082635 445 9659696 SGTC_1743 st037606 46.3785 µM 0.283819900645467 0.384817705372751 no 1281 0.388274201444976 376 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_320 4092-0846 5.34 µM 0.283359654028923 0.385011255918669 no 1282 0.388450576433748 415 1359356 SGTC_258 haloperidol 50.781 µM 0.283219708700739 0.385070113733981 no 1283 0.388504210625881 410 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1856 st057054 55.7 µM 0.283127821284937 0.385108760926943 no 1284 0.388539427729479 431 1266018 SGTC_1485 3909-9022 254 µM 0.282791003471209 0.385250433857673 no 1285 0.388668525576387 431 714516 SGTC_75 0159-0059 199.013 µM 0.282650152757842 0.38530968328756 no 1286 0.388722515453193 452 5377270 SGTC_12 0849-0099 9.267 µM 0.282272251182218 0.385468662357714 no 1287 0.388867380569305 436 6071388 SGTC_1796 st049173 110.4 µM 0.282027558390354 0.385571612212945 no 1288 0.388961189559255 438 94134 SGTC_691 1548-0686 185 µM 0.281491886269936 0.385797014241179 no 1289 0.389166575211742 440 46495133 SGTC_170 4197-0004 226 µM 0.281338425904414 0.385861594952014 no 1290 0.389225420192979 411 218692 SGTC_195 4234-0266 16.654 µM 0.280103206558207 0.386381527258224 no 1291 0.38969916233119 418 2303354 SGTC_2478 5763493 32.33 µM 0.280015710204968 0.386418364241235 no 1292 0.389732725923981 429 1365576 YLR208W SEC13 SGTC_2135 5326629 150.42 µM 0.27976205010979 0.386525163878036 no 1293 0.389830034559289 403 5020077 SGTC_1883 5-benzylidenerhodanine 20 µM 0.278975661524379 0.38685631515707 no 1294 0.390131751416285 421 1273210 SGTC_1889 st059080 5.18 µM 0.277632502672272 0.387422114966525 no 1295 0.390647239551675 404 176925 Isolated from Daphnopsis sellowiana. SGTC_2532 xanthone 78.9 µM 0.274940814985103 0.388556695580047 no 1296 0.391680854606036 439 7020 An insecticide. SGTC_923 1900-2434 73.3 µM 0.2741960059056 0.388870810557306 no 1297 0.391966998684788 463 5910570 SGTC_2973 9094665 17.96 µM 0.273797723554541 0.389038811556254 no 1298 0.39212003656874 457 25237061 YIL048W NEO1 SGTC_493 zm226600 134 µM 0.272608217126132 0.389540685207829 no 1299 0.392577197380535 447 5240098 A potassium channel opener. YCR052W RSC6 SGTC_96 0929-0093 37.281 µM 0.272365018625969 0.389643317641992 no 1300 0.392670683686849 388 6991579 SGTC_43 0570-0105 72.5 µM 0.271551254133609 0.389986791106065 no 1301 0.392983542442875 443 1114046 YDL195W SEC31 SGTC_2274 7947094 46.08 µM 0.271470873638767 0.39002072274696 no 1302 0.393014449170507 400 2971028 SGTC_1291 0993-0025 5.79 µM 0.271443452820122 0.390032298301247 no 1303 0.393024992775354 431 4353356 SGTC_58 0957-0393 9 µM 0.269215030564328 0.390973340142115 no 1304 0.39388210720311 411 6997992 SGTC_560 2332-1943 155 µM 0.268070215304134 0.391457033620828 no 1305 0.394322635880367 430 21177716 SGTC_1370 2001-0092 44.6 µM 0.267298715925656 0.391783092932692 no 1306 0.394619587676607 453 790957 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.266981507512283 0.391917177011246 no 1307 0.394741699664414 425 66535 A nucleotide analog. SGTC_2601 securinine 100 µM 0.266800585786123 0.391993658421964 no 1308 0.394811351603183 443 442872 A GABA receptor antagonist. SGTC_791 1348-1292 225 µM 0.26647197948842 0.392132581505202 no 1309 0.394937868311333 419 5437054 SGTC_1746 st038117 42 µM 0.266384185566699 0.392169699988649 no 1310 0.394971671724358 445 2898218 SGTC_2112 5488546 200 µM 0.265727788971743 0.392447249658499 no 1311 0.395224430032332 429 600757 SGTC_1730 st033808 45.1 µM 0.265659235464607 0.392476239870028 no 1312 0.395250830441579 435 1045166 SGTC_2971 9092186 9.93 µM 0.264160834743385 0.393110039002547 no 1313 0.395827994380415 366 25236400 SGTC_256 clotrimazole 625 nM 0.263158874040815 0.393534010324997 no 1314 0.39621406381296 423 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3282 9108498 15.4605 µM 0.263049374405763 0.393580351845403 no 1315 0.396256261727132 425 16459645 SGTC_1818 st052136 56.3 µM 0.262863722558503 0.393658925312791 no 1316 0.396327809224147 439 674169 SGTC_2946 9065502 71.43 µM 0.260678577521054 0.394584069276789 no 1317 0.39717019383969 407 16489101 SGTC_521 r062-0005 13.8 µM 0.260122407392078 0.394819635066095 no 1318 0.397384677054218 418 2832033 SGTC_3061 glucosamine 200 µM 0.259478399213533 0.395092452693941 no 1319 0.397633073179573 458 91431 and experimental redox chemotherapeutic SGTC_2451 5856223 45.7 µM 0.259015738095298 0.395288479026337 no 1320 0.397811548761728 423 2179896 SGTC_2220 6782180 200 µM 0.257471389905025 0.395943000326645 no 1321 0.398407449270696 439 833803 SGTC_3208 9114115 49.47 µM 0.255789456929269 0.39665616626554 no 1322 0.399056707653104 445 650895 SGTC_2700 st077718 96.8 µM 0.25572589385626 0.396683124801332 no 1323 0.399081249707722 411 904970 SGTC_3114 9122766 49.47 µM 0.255652928545183 0.3967140716476 no 1324 0.399109422510345 399 17176985 SGTC_1693 xanthone 101.9 µM 0.253710222129707 0.397538272223029 no 1325 0.39985971814374 447 7020 An insecticide. SGTC_2027 5150920 200 µM 0.252015514758269 0.398257632150805 no 1326 0.400514535860807 450 786715 SGTC_1114 scopoletin 1.73284 µM 0.251757955852591 0.398366989659304 no 1327 0.40061407853657 458 5280460 A coumarin with genotoxic properties. SGTC_2639 lactacystin 53 µM 0.251179035309844 0.398612823942951 no 1328 0.400837846242767 406 3870 A proteasome inhibitor. SGTC_2612 dictamnine 15.46 µM 0.250799941090337 0.398773825277395 no 1329 0.400984393561938 451 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2913 7966556 36.57 µM 0.250606591647188 0.398855947431226 no 1330 0.401059142465156 445 2976516 SGTC_2168 5727979 200 µM 0.248799482065457 0.399623705015135 no 1331 0.401757945881809 413 695210 SGTC_871 0574-0004 149 µM 0.246316227171261 0.400679358440226 no 1332 0.402718724691715 433 9551173 SGTC_1013 4112-3890 241 µM 0.245812756108703 0.400893477146385 no 1333 0.402913591020049 408 705171 SGTC_2722 naftopidil 47.16 µM 0.245435352222234 0.401054000899396 no 1334 0.403059679403422 441 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_287 k060-0039 29.6 µM 0.243593788703022 0.401837524753614 no 1335 0.40377271965656 421 5861974 SGTC_2080 5212524 12.4 µM 0.243398830769127 0.401920496011869 no 1336 0.403848224745001 424 260183 SGTC_956 1185-0240 191 µM 0.243128769494364 0.402035437460802 no 1337 0.40395282245961 425 1416193 SGTC_2361 9034121 116 µM 0.242005974671296 0.40251340368468 no 1338 0.404387766850595 434 6496917 SGTC_2007 4011539 71.82 µM 0.24173224978467 0.402629948659524 no 1339 0.40449381939452 426 45595301 SGTC_3096 9117468 49.47 µM 0.241729687343889 0.402631039721413 no 1340 0.404494812225115 463 41316311 SGTC_2618 avocadyne 43.43 µM 0.241606138313777 0.402683646573594 no 1341 0.404542682649004 445 3015189 SGTC_177 1327-0068 8.361 µM 0.241463252098899 0.402744489345498 no 1342 0.404598047258667 405 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3147 9097027 49.47 µM 0.240101978085061 0.403324255086432 no 1343 0.405125600385844 444 25236841 SGTC_730 1436-0052 41.2 µM 0.239983314833432 0.403374803780085 no 1344 0.405171595762941 417 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1378 2093-0007 380 nM 0.239539616589911 0.403563826605956 no 1345 0.405343590414116 463 3618014 SGTC_2840 9008771 71.43 µM 0.238848850305867 0.403858149346631 no 1346 0.40561139459507 420 2992978 SGTC_1488 4013-0813 75.9 µM 0.23723280405503 0.404546929172543 no 1347 0.406238094312084 430 2910057 SGTC_307 1501-1223 22.3 µM 0.236848554924993 0.404710744749292 no 1348 0.406387140826942 452 2830329 SGTC_677 0929-0063 136 µM 0.236101914356345 0.405029105127037 no 1349 0.406676794239587 450 1539583 SGTC_2463 5473429 200 µM 0.235941657987836 0.405097445107052 no 1350 0.406738971115461 446 5399405 SGTC_2730 imipramine 71.33 µM 0.235543334264094 0.40526731943978 no 1351 0.406893524450785 407 3696 A tricyclic antidepressant. SGTC_1067 clotrimazole 1.36 µM 0.232831512569802 0.406424311121245 no 1352 0.407946120903085 424 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2752 diclazuril 33.15 µM 0.232343527512347 0.406632595757121 no 1353 0.408135603610306 433 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1397 3532-0190 20.1 µM 0.23229050078657 0.406655230526591 no 1354 0.408156194977414 421 5322280 SGTC_3085 9117376 49.47 µM 0.232173816144965 0.406705039149527 no 1355 0.408201506914219 456 16480349 SGTC_2193 5925765 200 µM 0.231857613429498 0.406840022696737 no 1356 0.408324303514393 422 877370 SGTC_2737 bleomycin 30.5 nM 0.231737402690965 0.406891342276024 no 1357 0.408370989441889 461 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1531 st059297 52.4 µM 0.229120950426837 0.408008735554829 no 1358 0.409387455229514 435 7566702 SGTC_2265 7929201 200 µM 0.228880186604582 0.408111594929917 no 1359 0.409481020315101 466 1265108 SGTC_932 2857-0803 154 µM 0.228621340655047 0.408222186434188 no 1360 0.409581618187017 446 674898 SGTC_156 3474-0145 5.642 µM 0.228515964837801 0.40826721017245 no 1361 0.409622573142817 451 2265471 SGTC_15 0266-0086 27.098 µM 0.227208977232293 0.408825744928501 no 1362 0.410130623706218 460 1712902 YIL048W NEO1 SGTC_143 4032-1194 15.74 µM 0.22597304128062 0.409354086511137 no 1363 0.410611193985879 430 1806963 SGTC_1421 4029-0249 71.4 µM 0.225859635184007 0.409402573950696 no 1364 0.410655296532277 449 2894095 SGTC_3137 9097352 49.47 µM 0.225651276371507 0.409491662590883 no 1365 0.410736328225763 464 44120435 SGTC_1985 st071382 65.5 µM 0.225063948335954 0.40974281344949 no 1366 0.410964763275605 440 6123237 SGTC_2129 girgensonine 121.053 µM 0.22392166900468 0.410231376334423 no 1367 0.411409127194212 474 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_617 3770-0098 35 µM 0.223444788539204 0.410435383570255 no 1368 0.411594674566819 431 5962639 SGTC_1142 3253-1408 9.78 µM 0.221563938456393 0.411240238255024 no 1369 0.412326678843305 453 256655 SGTC_515 4092-1064 102 µM 0.220950416038869 0.411502858200659 no 1370 0.412565520518731 466 717353 SGTC_778 3456-2434 196 µM 0.220652893907822 0.411630227646224 no 1371 0.412681356286191 419 5539063 SGTC_2372 9071633 200 µM 0.220060755372747 0.411883750292008 no 1372 0.412911919139393 450 21321366 SGTC_2544 sphondin 68.51 µM 0.218840888919925 0.412406148926765 no 1373 0.413386997016758 459 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2540 epiandrosterone 100 µM 0.217641591645874 0.412919890291447 no 1374 0.413854187868143 448 441302 A steroid. SGTC_187 1488-2104 32.728 µM 0.216157605950884 0.413555789666347 no 1375 0.414432448938526 451 2852859 SGTC_81 0411-0046 9.971 µM 0.215614530517902 0.413788558472105 no 1376 0.41464411424563 428 12925265 SGTC_2702 st077768 96.8 µM 0.215180326922308 0.413974685267991 no 1377 0.41481336425574 421 6484119 SGTC_2166 5933061 31.504 µM 0.214809766351811 0.414133545971894 no 1378 0.414957819096901 440 2877375 SGTC_2980 9014342 25.29 µM 0.214803172558683 0.414136372883 no 1379 0.414960389645474 463 2996599 SGTC_2048 5246248 200 µM 0.2129368101886 0.414936703750016 no 1380 0.415688125176351 464 677046 SGTC_228 caffeine 993.056 µM 0.212528314762233 0.415111921403468 no 1381 0.415847445152189 437 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_688 0527-0193 473 µM 0.212082069618401 0.415303350498789 no 1382 0.41602150395032 460 4007154 SGTC_2024 5144227 134 µM 0.211995972100243 0.415340286706234 no 1383 0.416055088353872 440 3475211 SGTC_1668 st014914 51.6 µM 0.2113437590092 0.415620113219463 no 1384 0.416309519618422 467 2839556 SGTC_1637 st007924 17.4 µM 0.211312397395787 0.415633569734077 no 1385 0.416321754809703 449 683336 SGTC_1832 st054113 55 µM 0.209763328300019 0.416298360880226 no 1386 0.416926198020477 461 1251267 SGTC_813 k007-0158 173 µM 0.209549055443849 0.416390336102791 no 1387 0.417009822294516 480 6523916 SGTC_121 0557-0495 61.343 µM 0.209437607716814 0.416438176121145 no 1388 0.417053318486926 476 3104427 SGTC_2735 sertaconazole 140 nM 0.208707500776007 0.416751612196061 no 1389 0.417338292158841 443 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_905 2-aminofluorene 215 µM 0.208372400087707 0.416895489190253 no 1390 0.417469102442295 438 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1477 0139-0234 16 µM 0.207713664550578 0.417178352700454 no 1391 0.417726273804689 442 620880 SGTC_270 tamoxifen 5.46 µM 0.206934091117958 0.417513159837629 no 1392 0.418030665923951 466 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1491 4138-0063 26.5 µM 0.205778678878359 0.418009490212956 no 1393 0.418481898281213 460 23883227 SGTC_690 glyoxal 20.3 µM 0.205294119709006 0.418217681189586 no 1394 0.418671169006705 452 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1697 st025554 27.742 µM 0.20397629804272 0.418783999366892 no 1395 0.419186010468815 440 1269519 SGTC_1190 1486-1332 13 µM 0.203623861974764 0.418935483153148 no 1396 0.419323722319525 469 4150046 SGTC_1560 lithocholic acid 53.1 µM 0.203024943643207 0.419192937303646 no 1397 0.419557767995689 468 9903 A bile acid which acts as a detergent. SGTC_3144 9087057 49.47 µM 0.202697006093278 0.419333920913065 no 1398 0.419685931697684 484 17249618 SGTC_1651 st011928 86.1 µM 0.202275914034793 0.419514967756251 no 1399 0.419850514294496 460 720198 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.202203583486762 0.419546067701375 no 1400 0.419878785888815 430 165521 SGTC_1481 3346-2004 36 µM 0.201668675693329 0.419776077441206 no 1401 0.420087876298041 475 2770522 SGTC_2823 7987624 58.44 µM 0.201193731058769 0.41998032606579 no 1402 0.420273546581547 452 2239440 SGTC_1204 4049-0315 18.3 µM 0.200372829061663 0.420333403489296 no 1403 0.420594503919027 418 588402 SGTC_2492 derrusnin 100 µM 0.199632266707791 0.420651981119544 no 1404 0.420884095263019 472 1715307 Part of coumarin class of compounds. SGTC_2895 9054447 58.44 µM 0.197529722339492 0.421556743393951 no 1405 0.421706512273497 442 2697450 SGTC_2085 5307070 144.047 µM 0.197298121472861 0.421656430787445 no 1406 0.421797124651293 461 2840351 SGTC_2844 9010103 25.97 µM 0.197219059999615 0.421690462173513 no 1407 0.421828057902092 463 2480525 SGTC_1499 4480-0877 67.3 µM 0.196319354446167 0.422077774453184 no 1408 0.422180106743818 461 2861909 SGTC_1998 st075797 76.8 µM 0.195027360653688 0.42263409378565 no 1409 0.422685764084837 476 24208315 SGTC_1514 1189-1591 158 µM 0.194163719564523 0.423006054960177 no 1410 0.423023844912238 481 767698 YMR146C TIF34 SGTC_811 0416-0114 265 µM 0.193324213764141 0.423367687118165 no 1411 0.423352532087067 474 6612453 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.193270878975333 0.42339066421806 no 1412 0.423373415773741 441 688664 SGTC_1866 st057638 64 µM 0.19289563482531 0.423552330085221 no 1413 0.423520351869561 460 688802 SGTC_2582 agaric acid 100 µM 0.19228310391342 0.423816253485906 no 1414 0.42376022628771 441 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_949 1165-0505 146 µM 0.190336981703102 0.424655012411744 no 1415 0.424522538050916 439 6244267 SGTC_1176 0848-0131 83.3 µM 0.190093366807117 0.424760032071845 no 1416 0.424617983917191 482 6769040 SGTC_714 4296-0578 26.1 µM 0.189628256896748 0.424960550584209 no 1417 0.424800221573328 458 1589775 SGTC_3306 9127676 59.7925 µM 0.188262515638817 0.425549461946559 no 1418 0.425335434048915 425 41905287 SGTC_994 3910-0338 138 µM 0.186167214359594 0.426453284102564 no 1419 0.426156816813357 468 3479481 SGTC_2650 prasterone 100 µM 0.185070202824891 0.42692664173708 no 1420 0.426586986280586 470 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_909 3448-9333 149 µM 0.184120566439104 0.427336492393399 no 1421 0.42695943630345 448 3344074 SGTC_2311 7694451 200 µM 0.182109635220357 0.428204642421052 no 1422 0.427748343680054 487 2163142 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.18148541113432 0.428474200483284 no 1423 0.427993291619896 443 4330530 SGTC_1263 0774-1208 64.8 µM 0.180735612199399 0.428798029515509 no 1424 0.428287552293448 475 906585 SGTC_1433 4060-0023 7.6 µM 0.180516221059828 0.428892790952946 no 1425 0.428373660503883 462 3840627 SGTC_2981 9013952 38.96 µM 0.179671934140694 0.429257501309986 no 1426 0.428705064077415 414 2996344 SGTC_668 1682-0499 62.6 µM 0.178320410852704 0.42984145040726 no 1427 0.42923567507863 460 682214 SGTC_2841 9004761 38.96 µM 0.178246729933336 0.429873289951701 no 1428 0.429264606053633 427 2991039 SGTC_97 0535-0701 19.132 µM 0.177714006188393 0.430103508037804 no 1429 0.429473792498973 448 2832013 YGL099W LSG1 SGTC_696 1560-0013 611 µM 0.177177203371123 0.430335512944895 no 1430 0.429684600720562 431 1650269 SGTC_109 0132-0036 33.701 µM 0.175877170159148 0.430897483725795 no 1431 0.430195220665358 492 67274 A color developer. SGTC_2622 2-methoxyxanthone 59.94 µM 0.175318512689067 0.431139019979085 no 1432 0.430414683013646 465 71034 A hepatoprotective. SGTC_1063 disulfiram 1.84 µM 0.173911530458047 0.431747444416585 no 1433 0.430967495363084 446 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_574 1315-0397 40 µM 0.172344252947416 0.432425376310464 no 1434 0.431583447990798 472 6794277 SGTC_832 4083-0019 164 µM 0.172107409569421 0.432527841177698 no 1435 0.431676543846274 464 1990758 SGTC_1767 st044992 70.3 µM 0.171659574638475 0.43272159910797 no 1436 0.43185258436667 488 9600693 SGTC_814 3342-0569 96 µM 0.171632043154862 0.432733511264689 no 1437 0.431863407226341 477 4346283 SGTC_100 0086-0128 49.5915 µM 0.170851310405348 0.433071339420965 no 1438 0.432170341148565 469 93297 SGTC_2956 9076196 2.52 µM 0.17065608463744 0.433155822539813 no 1439 0.432247097775382 501 16423868 SGTC_2246 7293507 91.5585 µM 0.169998695208527 0.433440327454079 no 1440 0.432505581393836 490 887656 SGTC_3170 9103054 49.47 µM 0.16825147313327 0.434196657291542 no 1441 0.433192724183818 468 16432970 SGTC_875 0709-0210 25.7 µM 0.168124930353856 0.434251443965685 no 1442 0.433242498457545 477 6251364 SGTC_2307 7538926 6.34 µM 0.168014545652877 0.434299236033923 no 1443 0.433285917985554 468 96582 SGTC_1609 st001574 46.4 µM 0.167512976402933 0.434516407123264 no 1444 0.433483219048476 500 3960012 SGTC_3027 9089541 49.47 µM 0.166031005433903 0.435158190955871 no 1445 0.434066274995618 464 9943819 SGTC_749 1000-0129 128 µM 0.164904453533367 0.435646171047807 no 1446 0.434509593490503 468 708470 SGTC_1219 1469-0211 33.1 µM 0.164096528126836 0.435996194463564 no 1447 0.434827577459707 496 6822282 SGTC_2888 9058547 12.99 µM 0.163718417790475 0.436160023201041 no 1448 0.434976408942706 445 16476514 SGTC_1686 st019653 115.5 µM 0.162591818257992 0.436648224328856 no 1449 0.435419914676657 488 97252 SGTC_2203 7227154 166.4 µM 0.162136637750937 0.436845499861788 no 1450 0.435599127569784 456 896304 SGTC_1708 st033234 31.827 µM 0.161964405215127 0.436920149655286 no 1451 0.435666942121294 445 674664 SGTC_3322 9139058 2.11 µM 0.161928126547684 0.43693587400354 no 1452 0.4356812266646 441 4908926 YPR165W RHO1 SGTC_937 3122-0005 46.7 µM 0.161643290326329 0.43705933469771 no 1453 0.435793382412209 485 759535 SGTC_970 1315-0089 19.5 µM 0.159332190682464 0.438061293740811 no 1454 0.436703580103509 475 6811083 YLR033W RSC58 SGTC_2074 5212007 75.395 µM 0.158761962742362 0.438308572913151 no 1455 0.436928208989103 500 758611 SGTC_356 1634-0012 32.5 µM 0.157830679101448 0.438712475531257 no 1456 0.437295111605516 489 735457 SGTC_221 trifluoperazine 10.304 µM 0.157493645407465 0.438858664571809 no 1457 0.437427907814652 494 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1970 st070122 35.8 µM 0.153773540673614 0.440472817234133 no 1458 0.438894148573865 491 102928 SGTC_1760 st045453 10.4495 µM 0.151029109533043 0.441664261254733 no 1459 0.439976376593254 507 3323419 YIL048W NEO1 SGTC_3128 9127691 49.47 µM 0.150442261354884 0.441919099430369 no 1460 0.440207850458823 486 41316314 SGTC_1303 1160-0052 261 µM 0.150096759955594 0.442069144283191 no 1461 0.440344138104273 493 3562476 SGTC_1809 st050081 57.6 µM 0.14988164671422 0.442162568176107 no 1462 0.440428995969061 489 5036894 SGTC_1785 bathophenanthroline 24 µM 0.1496533725795 0.442261711376081 no 1463 0.440519048534763 450 72812 An iron chelator. SGTC_3145 9085516 49.47 µM 0.148869664956113 0.442602115932074 no 1464 0.440828239149451 452 25236195 SGTC_1895 st058434 18.3 µM 0.14839545683717 0.44280810951964 no 1465 0.441015342648274 487 5393175 SGTC_1132 3456-3614 2.5 µM 0.148134544587171 0.442921455067128 no 1466 0.441118293772414 450 3125502 SGTC_444 curcumin 90.4 µM 0.146481434299697 0.443639707724445 no 1467 0.441770672555378 467 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1400 3771-8998 51.5 µM 0.146191482080599 0.443765706952094 no 1468 0.441885114817119 480 670767 SGTC_3080 9117754 49.47 µM 0.146157161054191 0.443780621588746 no 1469 0.441898661425091 486 9550191 SGTC_3076 9116187 49.47 µM 0.145829562205158 0.443922987821774 no 1470 0.442027969052007 487 27241210 SGTC_551 k048-0028 34.9 µM 0.145524827340612 0.444055424438667 no 1471 0.442148257506103 483 6836383 SGTC_1839 st053978 48 µM 0.144958482500391 0.444301572342802 no 1472 0.442371825822952 467 3788398 SGTC_1578 josamycin 24.2 µM 0.14495455398911 0.444303279849087 no 1473 0.442373376692567 453 5282165 A P450 substrate. SGTC_94 0334-0113 514.748 µM 0.144364108614457 0.444559925489121 no 1474 0.442606478527045 498 6795178 SGTC_611 3453-1652 23.7 µM 0.142938080909315 0.44517986476008 no 1475 0.443169541567722 478 1560575 SGTC_720 r052-1644 49.9 µM 0.142276842140363 0.445467371728086 no 1476 0.44343066886132 471 1422863 YOR257W CDC31 SGTC_1987 st072290 61.9 µM 0.141564627721984 0.445777075015842 no 1477 0.443711954233699 491 54697379 SGTC_1425 4048-4433 7.33 µM 0.141522915003924 0.445795214634212 no 1478 0.443728429334831 496 23734946 SGTC_2388 9080168 200 µM 0.139253946868436 0.44678209121726 no 1479 0.444624740147541 504 15943073 SGTC_2930 9013230 14.89 µM 0.137855439057718 0.447390529951721 no 1480 0.445177334273767 473 2995857 SGTC_308 4092-1169 104 µM 0.137311660786682 0.447627141166067 no 1481 0.445392226883099 479 2268590 YDL196W YDL196W SGTC_86 0417-1630 471.922 µM 0.136178915966779 0.448120085873893 no 1482 0.445839921252254 463 3634867 SGTC_131 0141-0277 33.849 µM 0.13523793517972 0.448529640207626 no 1483 0.446211877325264 481 1547771 SGTC_640 3381-0960 37.1 µM 0.134979692053972 0.448642048067311 no 1484 0.446313965383549 478 1745025 SGTC_1112 tnp00069 1.16933 µM 0.134122592004824 0.449015155387677 no 1485 0.446652817604886 503 145826 SGTC_2357 9067248 200 µM 0.134003922655813 0.449066817332062 no 1486 0.446699736291609 482 9150235 SGTC_2158 5657123 3.6195 µM 0.133660866718027 0.449216169400381 no 1487 0.446835375628003 496 2858827 SGTC_2642 cholecalciferol 100 µM 0.130881293804353 0.450426541580166 no 1488 0.447934606380106 477 9821465 A vitamin D precursor, similar to steriods. SGTC_1450 4112-4260 37.6 µM 0.1307188716347 0.450497283103711 no 1489 0.447998851519274 492 1633175 SGTC_2744 captopril 92.04 µM 0.130091370280782 0.45077060046204 no 1490 0.448247068809179 492 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_4 0960-0234 25.671 µM 0.129785827580173 0.450903692496695 no 1491 0.448367938011084 449 6821112 SGTC_250 brefeldin a 552.239 µM 0.129763874973316 0.450913255095002 no 1492 0.448376622396268 490 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2313 7726885 200 µM 0.129629478062577 0.450971799272033 no 1493 0.448429789948742 464 726423 SGTC_741 4582-0002 126 µM 0.129454736334576 0.451047919511168 no 1494 0.448498919336296 484 2912688 SGTC_2486 5283202 22.39 µM 0.129294123728236 0.451117886471053 no 1495 0.448562460496485 468 1377751 SGTC_1518 st038567 90.8 µM 0.128306859390642 0.451547997350689 no 1496 0.448953068483525 500 77966 SGTC_2791 5663188 71.43 µM 0.12720741515006 0.452027047373024 no 1497 0.449388118310573 506 54690634 SGTC_3238 9133470 49.47 µM 0.126551907440499 0.452312698583498 no 1498 0.449647531544863 488 3534688 SGTC_954 1189-0853 2.85 µM 0.125971603089326 0.452565598960671 no 1499 0.449877201464674 485 2828194 SGTC_768 0384-0033 77.3 µM 0.125950438542045 0.452574822971176 no 1500 0.449885578179911 463 3965305 YMR134W ERG29 SGTC_1155 4088-0394 48.2 µM 0.124342094294246 0.45327585196406 no 1501 0.450522209732583 490 2326248 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.124158461846136 0.453355901141547 no 1502 0.450594905167913 485 616764 SGTC_585 0kpi-0023 191 µM 0.123675818176638 0.453566304515941 no 1503 0.450785979469418 490 64601 SGTC_1733 st037357 54.9 µM 0.123078613129571 0.453826667740149 no 1504 0.451022423376475 503 1272339 YGL099W LSG1 SGTC_70 0141-0289 43.283 µM 0.122835758121604 0.453932550814405 no 1505 0.451118578890626 471 352408 SGTC_547 1120-0019 610 nM 0.122767046346624 0.453962509259284 no 1506 0.451145785010845 498 3676939 SGTC_492 tmb-8 126 µM 0.120961349137148 0.45474988953973 no 1507 0.451860824630622 498 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_502 l-744,832 89.3 µM 0.12087482528256 0.454787623043784 no 1508 0.451895091227444 510 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1417 3966-0327 90.4 µM 0.120589577270199 0.454912024076738 no 1509 0.452008062363381 500 651118 SGTC_3291 9121177 71.43 µM 0.120511056382488 0.454946269016796 no 1510 0.452039160874747 474 17015612 SGTC_2745 rifampicin 24.3 µM 0.120280471946031 0.455046834641098 no 1511 0.452130486462513 511 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_862 0452-0056 10.2 µM 0.119516755651747 0.455379937528967 no 1512 0.452432983045558 501 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3183 9108214 49.47 µM 0.118726071046541 0.455724835979592 no 1513 0.452746190462378 507 4974831 SGTC_1761 st044296 37 µM 0.118625401180511 0.45576875080774 no 1514 0.452786070106094 481 1826700 SGTC_957 1187-1561 14.1 µM 0.117137796003046 0.456417745796419 no 1515 0.453375429505131 504 1538454 SGTC_178 4092-0806 87.505 µM 0.116268656029389 0.456796977945888 no 1516 0.453719812984112 486 2169044 SGTC_2746 daunorubicin 9.88 µM 0.115602805154164 0.457087535531231 no 1517 0.453983669811662 493 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.1142621500006 0.45767262714186 no 1518 0.454514992932359 471 688664 SGTC_1059 3448-6867 171 µM 0.114003898933387 0.457785344206688 no 1519 0.454617351347797 495 3934407 SGTC_1749 st037932 54.2 µM 0.113927026518733 0.457818896836295 no 1520 0.454647820491762 486 594497 SGTC_1460 k062-0059 9.15 µM 0.113452236662783 0.458026135800733 no 1521 0.454836014067067 450 1373085 SGTC_1440 4100-1550 40 µM 0.113387372621074 0.458054448912136 no 1522 0.454861725168317 504 742806 SGTC_3216 9129716 49.47 µM 0.113373893771967 0.458060332447592 no 1523 0.45486706799902 471 8056934 SGTC_190 3970-0790 3.722 µM 0.113347467789018 0.458071867450755 no 1524 0.454877542919492 497 2832352 SGTC_2021 4019055 173 µM 0.112671537895199 0.458366924401542 no 1525 0.455145483498935 496 44827708 YER133W GLC7 SGTC_310 1273-0058 1.06 µM 0.111878393757761 0.458713176962222 no 1526 0.455459914158743 481 2734232 SGTC_3196 9111891 49.47 µM 0.111372718918701 0.45893394918187 no 1527 0.45566039630086 507 18891510 SGTC_2438 5259590 200 µM 0.110449165363848 0.459337195418176 no 1528 0.456026581642184 503 1201127 SGTC_48 0382-0018 55 µM 0.108618615637665 0.460136581778891 no 1529 0.456752497485502 476 762596 SGTC_675 1309-0189 238 µM 0.108581816153704 0.460152653481136 no 1530 0.456767092037169 472 4246530 SGTC_614 0462-0418 107 µM 0.108468459739739 0.460202160848873 no 1531 0.456812049176399 492 5188303 SGTC_2755 lomerizine 42.69 µM 0.108128063401027 0.460350829513686 no 1532 0.456947053640606 475 3949 A calcium channel blocker. SGTC_2041 5107442 45.335 µM 0.107478782610567 0.46063441932682 no 1533 0.457204578417007 488 793005 SGTC_841 0251-0215 91.2 µM 0.107046364645267 0.460823299931314 no 1534 0.457376098688717 510 3888614 SGTC_1278 0874-0585 172 µM 0.106146840242233 0.461216241369408 no 1535 0.457732923950163 488 766306 SGTC_590 k048-0076 22.4 µM 0.106029686563693 0.461267420691688 no 1536 0.457779399235405 490 6832814 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.105961573819988 0.461297176467688 no 1537 0.457806420071015 512 1241132 A phosphatase inhibitor. SGTC_2145 5634607 200 µM 0.105402848342361 0.461541269794206 no 1538 0.458028078002885 493 308662 SGTC_1185 1319-0113 81.3 µM 0.104934789630104 0.461745764212026 no 1539 0.458213776608424 502 4672763 SGTC_2803 7707263 71.43 µM 0.10465599698798 0.461867573268729 no 1540 0.45832438972908 483 2199229 SGTC_845 0330-0138 4.51 µM 0.104469820312128 0.461948918890337 no 1541 0.458398258552041 516 9039800 SGTC_56 0957-0365 83.25 µM 0.10427274167041 0.462035029609668 no 1542 0.45847645448427 508 6752360 SGTC_2097 5376186 200 µM 0.10404503607209 0.462134524559249 no 1543 0.458566804436358 466 742755 SGTC_3071 9117417 49.47 µM 0.103951878265887 0.462175230132147 no 1544 0.458603768586317 506 45595590 YGL055W OLE1 SGTC_935 2996-0153 430 µM 0.103580193354657 0.462337642868657 no 1545 0.458751253257846 517 23738523 SGTC_348 k064-0012 10.7 µM 0.103467266115788 0.462386989194249 no 1546 0.458796063941816 483 5066323 SGTC_2820 7989630 71.43 µM 0.103067454777353 0.462561701208415 no 1547 0.458954717376664 511 2984098 SGTC_904 1141-0088 396 µM 0.10262204757933 0.462756346485389 no 1548 0.459131471892316 491 1378119 SGTC_153 4077-0274 519.67 µM 0.101068984036246 0.463435112843562 no 1549 0.45974784954699 512 3121976 SGTC_427 1354-0053 47.3 µM 0.0994920306568454 0.464124429173722 no 1550 0.460373807560531 484 6813657 SGTC_3024 9090631 49.47 µM 0.0989943165372496 0.464342011944986 no 1551 0.460571391342715 508 25236383 SGTC_3287 9117173 37.0625 µM 0.0989619109560814 0.46435617887388 no 1552 0.460584256128563 507 2789709 SGTC_1415 3966-0071 78.1 µM 0.0983010683925471 0.464645092939934 no 1553 0.460846614918885 507 2893185 SGTC_1210 3013-0140 750 nM 0.0979582527622358 0.464794976016873 no 1554 0.460982721672176 503 905973 SGTC_2918 7977171 22.06 µM 0.0972060251917888 0.465123876347409 no 1555 0.461281391648284 503 2236483 SGTC_347 4534-1311 26.2 µM 0.096342507910954 0.465501465813571 no 1556 0.461624275826266 505 2862016 SGTC_337 1315-0038 354 µM 0.0961398826260145 0.465590072111384 no 1557 0.461704738119492 513 1626437 SGTC_2603 homopterocarpin 100 µM 0.0949476745063965 0.466111448891885 no 1558 0.462178194378662 492 101795 A weak amylase inhibitor. SGTC_509 pifithrin 175 µM 0.0949344435053431 0.466117235404876 no 1559 0.462183449048662 505 4817 A p53 inhibitor. SGTC_2790 5423970 71.43 µM 0.0930436824478704 0.466944223476744 no 1560 0.462934429071068 484 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_657 3534-0529 86.7 µM 0.0920355849663071 0.467385207445458 no 1561 0.463334883423982 497 1049549 SGTC_3108 9121785 49.47 µM 0.0916801522946366 0.467540698123629 no 1562 0.463476083571295 513 17140271 SGTC_352 k048-0007 5.11 µM 0.0914508876153926 0.467640996880095 no 1563 0.463567164321969 515 6811911 SGTC_828 2074-0507 139 µM 0.0911740838299423 0.467762095790947 no 1564 0.463677133637594 520 X828 SGTC_292 k038-0015 474 µM 0.0911130225331074 0.467788809904778 no 1565 0.463701392599659 485 46368540 SGTC_963 1269-2853 151 µM 0.0910182992928547 0.467830251293671 no 1566 0.463739025337861 479 3668223 SGTC_788 1182-0090 188 µM 0.0901493887444635 0.468210415606173 no 1567 0.464084251209394 459 5715185 SGTC_3123 9126162 49.47 µM 0.0899292112825349 0.468306751904478 no 1568 0.464171733973589 513 25239884 SGTC_868 0527-0199 213 µM 0.0890525354893018 0.468690350391619 no 1569 0.464520079323957 503 2849450 SGTC_2905 7799065 20.05 µM 0.0887092395698862 0.468840570982936 no 1570 0.464656494686801 510 1296806 SGTC_1807 st050092 58.9 µM 0.0879765822886161 0.469161184447699 no 1571 0.464947644293068 491 5008496 SGTC_2749 bexarotene 57.39 µM 0.0863906764200853 0.469855250787781 no 1572 0.465577929180296 501 82146 An retinoic acid receptor inhibitor. SGTC_316 k060-0003 58.6 µM 0.0851228677489889 0.470410168951197 no 1573 0.466081855225524 495 6152314 SGTC_2157 5649910 96.377 µM 0.0849496038591353 0.470486010812081 no 1574 0.4661507280508 504 2858091 SGTC_286 k060-0067 22.9 µM 0.0849048931134412 0.470505581977695 no 1575 0.466168500847562 491 5985051 SGTC_727 3032-0951 202 µM 0.0848356872397768 0.470535875498282 no 1576 0.46619601074157 505 3652836 SGTC_1326 1431-2094 10.8 µM 0.0839698296245038 0.470914902126955 no 1577 0.46654020974948 503 616278 SGTC_1254 0550-0035 264 µM 0.0837755656416278 0.470999944246177 no 1578 0.466617437752224 509 15121435 SGTC_1741 st038134 10.228 µM 0.0836738344888148 0.471044479188992 no 1579 0.466657880612902 509 1272587 SGTC_2706 st078239 82.5 µM 0.0820714601987545 0.471745999506065 no 1580 0.467294944001832 514 15434492 SGTC_2091 4-phenylthiadiazole 200 µM 0.0817778815574415 0.471874537958139 no 1581 0.467411672555351 509 270010 SGTC_2940 9060638 45.86 µM 0.0815770503359676 0.471962470206426 no 1582 0.467491525817083 486 4027022 SGTC_334 1502-1024 68.5 µM 0.0815542368768567 0.471972458972674 no 1583 0.467500596845672 511 3296216 SGTC_373 0844-0104 25.9 µM 0.0815308203880966 0.471982711790964 no 1584 0.467509907666902 505 5375804 SGTC_381 3461-2219 42.7 µM 0.080743879723795 0.472327281445455 no 1585 0.46782281987227 509 2883159 SGTC_2142 5622915 118.518 µM 0.0805948347424864 0.472392544586609 no 1586 0.467882087060914 513 5322196 SGTC_1086 cerivastatin 2.18 µM 0.0804147030815221 0.472471420811261 no 1587 0.467953716703426 508 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_525 k781-2675 26.7 µM 0.0801530560461909 0.472585992988361 no 1588 0.468057762912178 510 3651118 YDL195W SEC31 SGTC_1792 st045773 43.6 µM 0.0770631792987432 0.473939182865421 no 1589 0.469286642261442 514 2919270 SGTC_3150 9097574 49.47 µM 0.0770080841060873 0.473963314194587 no 1590 0.469308556940461 508 17217476 SGTC_3247 9135149 49.47 µM 0.076798811310339 0.474054975161761 no 1591 0.469391798192151 520 8934436 YOR116C RPO31 SGTC_2107 5363541 170.161 µM 0.074368904440619 0.475119367673302 no 1592 0.470358425463577 524 244052 SGTC_215 1287-0124 461.5 µM 0.0737208092084438 0.475403288584781 no 1593 0.470616270244042 510 5560863 SGTC_364 0083-0097 67.7 µM 0.0734381796662655 0.475527108316085 no 1594 0.470728718311711 504 5207356 SGTC_2997 9067075 71.4286 µM 0.073299525256007 0.475587853545096 no 1595 0.470783884738167 511 27209819 SGTC_3152 9099253 49.47 µM 0.0724507741839759 0.475959708184808 no 1596 0.471121589485509 507 25236131 SGTC_260 nsc-65238 3.989 µM 0.0722974149388826 0.476026900147622 no 1597 0.471182610947445 480 3246252 SGTC_2448 5185112 27.17 µM 0.071739226974797 0.476271467245443 no 1598 0.471404718979295 490 5718189 SGTC_2373 9071805 200 µM 0.0717225497420408 0.476278774424562 no 1599 0.471411355138001 507 10149009 SGTC_529 4076-0302 30.3 µM 0.0716454790693969 0.476312543272514 no 1600 0.471442022991695 483 5816522 SGTC_2234 tolnaftate 200 µM 0.0712708090631853 0.476476708972574 no 1601 0.47159111356308 512 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0707291520533998 0.476714048878561 no 1602 0.471806659474711 521 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1964 st076914 61 µM 0.0700308235310277 0.477020050313712 no 1603 0.472084563113264 516 24208661 SGTC_1644 st010134 20.9 µM 0.0679043373679884 0.477951940604509 no 1604 0.472930893002383 527 3818134 SGTC_2859 9028643 45.46 µM 0.0673215436914848 0.478207359612533 no 1605 0.473162863203952 501 17151580 SGTC_1246 0422-0085 105 µM 0.0669889444248919 0.478353130783645 no 1606 0.473295252250554 525 264295 SGTC_2053 5265679 138 µM 0.066196500456467 0.478700453721801 no 1607 0.473610691448323 511 764595 SGTC_651 3253-0966 34.4 µM 0.0659395873099787 0.478813060535739 no 1608 0.47371296151709 506 781462 SGTC_2411 st077133 39.94 µM 0.0656810327892529 0.478926388482837 no 1609 0.473815886721038 522 1403142 YNL221C POP1 SGTC_1591 genipin 88.4 µM 0.0639263557419101 0.479695531739565 no 1610 0.474514433173749 521 442424 A DNA cross-linking agent. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0627572455011217 0.480208040418007 no 1611 0.47497990593443 522 5024745 SGTC_490 phenamil 164 µM 0.0609371254784803 0.481006000306453 no 1612 0.475704641257458 527 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_780 0109-0199 192 µM 0.0607096794616777 0.481105720463631 no 1613 0.475795211403327 524 610414 SGTC_1201 1889-3372 45.9 µM 0.057867777161052 0.482351805849693 no 1614 0.47692697509711 505 5392199 SGTC_1404 3909-7820 48.3 µM 0.0576202781957039 0.482460334752118 no 1615 0.47702554842132 516 23741373 SGTC_2364 9055074 200 µM 0.0549941891733292 0.483611959694383 no 1616 0.478071546578386 512 6470630 SGTC_869 0564-0080 44.1 µM 0.0549123190701955 0.483647864629232 no 1617 0.478104158744732 491 6843321 SGTC_1236 0330-0013 258 µM 0.0547695820837791 0.483710463648295 no 1618 0.478161016997776 514 4617066 SGTC_1813 st051246 8.6015 µM 0.0542620966771452 0.483933030707064 no 1619 0.478363173755105 524 5291959 SGTC_1355 1499-0035 1.68 µM 0.0542378789130872 0.483943651978608 no 1620 0.478372821038401 514 1548538 SGTC_652 0437-0092 114 µM 0.0533111966774311 0.484350078815217 no 1621 0.478741979615368 517 3091274 SGTC_2627 acetyl isogambogic acid 100 µM 0.0531980894478649 0.484399686816076 no 1622 0.47878703893072 511 6857789 A caspase activator and apoptosis inducer. SGTC_725 1497-0963 19 µM 0.0530397343955667 0.484469140585454 no 1623 0.478850124391957 530 3549977 SGTC_220 paclitaxel 373.376 µM 0.0517547474305329 0.485032746969929 no 1624 0.479362056756644 513 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0515060031835582 0.485141851835061 no 1625 0.479461159177002 499 641818 YHR062C RPP1 SGTC_1725 st036284 20.55 µM 0.0513485247135572 0.485210926037189 no 1626 0.479523900973385 484 707914 SGTC_2653 dihydrofissinolide 100 µM 0.0506346328276014 0.485524063344666 no 1627 0.479808332602636 523 6857746 SGTC_3236 9132701 49.47 µM 0.0503909377795565 0.485630958350206 no 1628 0.479905428908909 532 24282524 SGTC_3248 9135562 49.47 µM 0.0502138108789123 0.485708654385451 no 1629 0.479976002974178 503 17650701 SGTC_3259 9138485 49.47 µM 0.0500715459064331 0.485771058762698 no 1630 0.480032687181644 495 17646153 SGTC_1811 st050069 61.5 µM 0.0488780628928709 0.48629459237912 no 1631 0.480508235618869 534 3877702 SGTC_534 k292-0788 63.4 µM 0.0484657365777063 0.486475469100114 no 1632 0.480672535293676 523 4146317 SGTC_563 tetrahydrosecaminediol 614 µM 0.0479212586082971 0.486714321536418 no 1633 0.480889498466619 523 334274 A psychoactive constituent of the cannabis plant. SGTC_2082 5219693 150 µM 0.0464575528073868 0.487356445645856 no 1634 0.481472782742595 526 2834649 SGTC_2160 5660466 132.927 µM 0.0438055620298951 0.488519949782749 no 1635 0.482529696741674 530 2859134 SGTC_3234 9132280 49.47 µM 0.0432733034139171 0.488753478938185 no 1636 0.482741836035529 510 17612295 SGTC_2298 7976326 193.81 µM 0.0423223253444364 0.489170731341525 no 1637 0.483120874088827 531 2235818 SGTC_2824 7998404 51.95 µM 0.0408761494118386 0.489805279983315 no 1638 0.483697315782029 525 837851 SGTC_802 4112-3352 742 µM 0.0400397634737185 0.490172278721297 no 1639 0.484030712514487 505 704594 SGTC_1004 4084-0029 199 µM 0.0391623613050981 0.490557283954817 no 1640 0.484380470964383 530 716894 YLR208W SEC13 SGTC_1447 4239-0816 81.9 µM 0.0384631759272228 0.490864093740839 no 1641 0.484659195549019 520 1341554 SGTC_1835 st008666 49.2 µM 0.0378291596743975 0.491142311317801 no 1642 0.48491194747412 526 690455 SGTC_2902 5787006 60.46 µM 0.0374155471266066 0.491323814170937 no 1643 0.485076838268026 520 591003 SGTC_321 4534-3890 65.3 µM 0.0361144420357522 0.49189478103366 no 1644 0.485595553380475 532 699746 SGTC_519 k048-0011 62.8 µM 0.0355304563325598 0.492151058258148 no 1645 0.485828380529915 516 6836379 SGTC_2507 purpurin 79.67 µM 0.0353314203434995 0.492238404277045 no 1646 0.4859077345769 538 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_655 k060-0012 42 µM 0.0349472036986177 0.492407017015171 no 1647 0.486060920236611 529 5994525 SGTC_837 0091-0265 12.5 µM 0.0329061706899992 0.493302742458816 no 1648 0.486874705981602 530 759367 SGTC_1101 ebselen 5.29 µM 0.0323397791498992 0.493551314589739 no 1649 0.487100543304568 532 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_405 ebelactone b 50 µM 0.0320920967755885 0.493660015691615 no 1650 0.487199303012535 526 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_848 0368-0089 85.6 µM 0.0319108450295644 0.49373956248441 no 1651 0.487271574981195 539 762535 SGTC_2969 9091408 28.7 µM 0.031415239765345 0.493957072322537 no 1652 0.487469193787433 499 4286311 SGTC_1684 st024538 14.6195 µM 0.0297922230498398 0.494669389545569 no 1653 0.488116380561267 542 6732859 SGTC_201 4262-0159 12.803 µM 0.029752482071546 0.494686831475812 no 1654 0.488132227892733 532 1341029 SGTC_2377 9073351 62.6 µM 0.0291500725094349 0.494951224419328 no 1655 0.488372450329156 528 7337946 YHR072W ERG7 SGTC_1840 st055363 71 µM 0.0278821972441597 0.495507692269868 no 1656 0.488878053732355 521 676033 SGTC_1027 k015-0025 8.67 µM 0.0276087267090374 0.495627719109356 no 1657 0.488987110706229 528 3598955 SGTC_1527 coumarin 137 µM 0.0267663832237768 0.495997428019621 no 1658 0.489323032953576 535 323 A hepatotoxic, DNA x-linker. SGTC_1438 4092-1045 4 µM 0.0262891401094719 0.496206894035608 no 1659 0.489513358428189 537 1351342 SGTC_410 α-linolenic acid 100 µM 0.0254534666256567 0.496573680638785 no 1660 0.48984663235096 536 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2397 5161689 200 µM 0.0247280578695078 0.496892073157441 no 1661 0.490135937488189 534 2259942 SGTC_2286 7945697 125 µM 0.0240375820475455 0.497195134942081 no 1662 0.490411315610364 529 1245733 SGTC_772 k072-0172 35.3 µM 0.0231989936783917 0.49756320804626 no 1663 0.490745770660419 535 5861980 SGTC_2434 5670830 169.91 µM 0.0230100949486896 0.497646119750966 no 1664 0.490821110238729 526 1549830 SGTC_182 3448-4371 550.524 µM 0.0228670214439435 0.49770891784926 no 1665 0.490878173294307 539 3491403 SGTC_3105 9121040 49.47 µM 0.022552187566438 0.497847105538931 no 1666 0.491003741455262 537 41448907 SGTC_3037 9091026 49.47 µM 0.0225064601339136 0.49786717636229 no 1667 0.491021979432353 538 25236398 YIL048W NEO1 SGTC_2470 5664817 21.68 µM 0.0221048943280435 0.498043433069815 no 1668 0.491182141160953 536 2859561 SGTC_1701 st028638 40.4 µM 0.0219577372293705 0.498108023890177 no 1669 0.491240834103536 528 3490878 SGTC_179 1273-0063 6.77 µM 0.0207272205099887 0.498648129306975 no 1670 0.491731627427427 539 3108139 SGTC_1046 2001-0062 216 µM 0.0196026112184876 0.499141751423464 no 1671 0.492180190391639 538 739778 SGTC_2948 9070189 9.45 µM 0.0193979313584178 0.499231591237491 no 1672 0.492261830317926 538 6473636 YDL196W YDL196W SGTC_2049 5262831 67.185 µM 0.0190522396904109 0.499383325232126 no 1673 0.492399715855718 533 763417 SGTC_66 0109-0187 42.4 µM 0.018549449624503 0.499604014375707 no 1674 0.492600264621768 522 759417 SGTC_743 1275-0778 158 µM 0.0185140979720175 0.499619531246721 no 1675 0.492614365469114 538 2849257 YMR203W TOM40 SGTC_3188 9110789 49.47 µM 0.0184770496723231 0.49963579282628 no 1676 0.492629143074454 531 849217 SGTC_666 0272-0154 136 µM 0.018052643527202 0.499822077101185 no 1677 0.492798428388998 540 6870312 SGTC_607 4491-0986 66.8 µM 0.0177969960575836 0.499934288276977 no 1678 0.492900400590122 540 698981 YDR232W HEM1 SGTC_2896 9052656 71.43 µM 0.0174975778430619 0.499934288276977 no 1679 0.493019832576366 541 6469436 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0172459419083227 0.499823837881467 no 1680 0.4931202056434 537 4000243 SGTC_2384 9036245 200 µM 0.0164205631945109 0.499461555084835 no 1681 0.493449437451737 539 6462766 SGTC_2605 digitonin 300 nM 0.0161483440494228 0.499342070243224 no 1682 0.493558022779443 544 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1757 st041620 31.8375 µM 0.015768864124854 0.499175505649763 no 1683 0.493709394088383 536 5289815 SGTC_1087 pterostilbene 9.05 µM 0.0154873590180127 0.499051945097495 no 1684 0.493821684663637 539 5281727 Similar to reservatol, lowers cholesterol. SGTC_2845 9003024 42.97 µM 0.0143483002373079 0.498551981037794 no 1685 0.494276052785835 537 2990173 SGTC_3050 9093513 49.47 µM 0.0135309726780789 0.498193234968536 no 1686 0.494602087619057 543 25236664 SGTC_856 0433-0016 11.3 µM 0.0132271392586044 0.498059875029904 no 1687 0.494723288767882 534 3911780 SGTC_2119 5528445 120.635 µM 0.0131588169382229 0.498029886717366 no 1688 0.494750543058201 537 791935 SGTC_584 0986-0246 15.4 µM 0.0119465764763914 0.497497807179865 no 1689 0.495234118902761 539 53315 YDR232W HEM1 SGTC_1764 st044502 93.5 µM 0.0116716810677067 0.497377150002403 no 1690 0.495343778657032 536 8407 SGTC_1107 amlodipine 47 µM 0.0111554561839453 0.497150569074444 no 1691 0.495549709173399 540 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_233 rapamycin 362 pM 0.00955734316412027 0.496449133000596 no 1692 0.496187229768472 540 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2268 7933382 153.85 µM 0.00906757497631488 0.496234168402489 no 1693 0.496382610532152 546 935025 YOR257W CDC31 SGTC_3131 9127911 49.47 µM 0.00811370992249773 0.495815509824482 no 1694 0.496763133576096 540 45595681 SGTC_3217 9129673 49.47 µM 0.00784921251757164 0.495699420711808 no 1695 0.496868649412741 541 17248312 SGTC_2301 7769476 200 µM 0.00774315800717953 0.495652873007112 no 1696 0.496910957755163 542 977820 SGTC_2245 6637752 200 µM 0.00708710710540941 0.495364931254933 no 1697 0.497172676997972 543 681890 SGTC_439 amiodarone 34.4 µM 0.00623717885088502 0.494991900046396 no 1698 0.49751174177917 537 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_737 1950-0117 57.9 µM 0.00600882210826851 0.494891675623448 no 1699 0.497602841230889 543 5393513 SGTC_2502 avocadyne acetate 18.59 µM 0.00573639171001079 0.494772107956189 no 1700 0.49771152336078 547 3952079 SGTC_1002 4049-0206 172 µM 0.00478373642672583 0.494353998429853 no 1701 0.49809157255987 545 4662749 SGTC_3034 9090421 49.47 µM 0.00446152595350811 0.494212585312895 no 1702 0.498220114566873 542 17173761 SGTC_2770 toltrazuril 17.5 µM 0.00391914361299876 0.493974543872448 no 1703 0.49843649191231 543 68591 Kills coccidiodes. SGTC_3077 9117319 49.47 µM 0.00292719843636364 0.49353920334249 no 1704 0.498832218448297 546 17154678 SGTC_1077 5-fluorocytosine 377 nM 0.00243704005665429 0.493324087600056 no 1705 0.499027762644748 546 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1954 st077032 68.9 µM 0.00239943562834694 0.493307584229031 no 1706 0.499042764597265 545 698907 SGTC_2474 5321570 43.32 µM 0.00175896853856433 0.493026505657396 no 1707 0.499298273441924 548 2841384 SGTC_488 nitrendipine 139 µM 0.00125959322266901 0.49280734971834 no 1708 0.499497495140247 547 4507 Dihydropyridine L-type calcium channel blocker. SGTC_180 1486-1293 102.781 µM 0.000918349374914498 0.492657592627881 no 1709 0.499633631657663 547 4140536 SGTC_1287 0971-0001 34.6 µM 0.00073769191073669 0.492578310337892 no 1710 0.499705703533589 547 4665869 SGTC_2071 5230951 39.92 µM 0.000716657175289892 0.492569079174533 no 1711 0.499714095176697 545 1799272 SGTC_2189 6047310 154.431 µM 0.000716546708374969 0.492569030695771 no 1712 0.499714139246609 546 711535 SGTC_1664 st014217 9.02 µM 0.000649706801467201 0.492539697807624 no 1713 0.499740804505266 543 3982782 SGTC_2798 7813637 45.45 µM 0.000369043267879518 0.492416528239281 no 1714 0.499852773040487 548 956368 SGTC_72 0744-0168 198.391 µM 0.000290150222255522 0.49238190605002 no 1715 0.499884246810299 547 677577 SGTC_2172 5754775 163.918 µM -0.000300604744516705 0.492122655252905 no 1716 0.499880076059529 548 2263357 SGTC_3300 9124615 50.48 µM -0.00233845009058783 0.491228380013416 no 1717 0.499067094238498 552 24824903 SGTC_3332 9141069 11.198 µM -0.00238843485397534 0.491206445549717 no 1718 0.499047153258703 549 17332883 SGTC_2089 5281248 129.67 µM -0.00256475765425313 0.491129071262764 no 1719 0.498976810854489 550 2737878 SGTC_2907 7721985 69.9 µM -0.00347301228621098 0.490730514690746 no 1720 0.498614471344009 554 3267881 SGTC_3333 9141820 12.094 µM -0.00408654683937577 0.490461291187773 no 1721 0.498369708222542 550 1939433 SGTC_2088 5278280 127.392 µM -0.00419086550197224 0.490415515815401 no 1722 0.498328091453842 550 791502 SGTC_1597 7-benzyloxygramine 47.5 µM -0.00540233329454473 0.48988392916356 no 1723 0.497844791319359 554 260807 SGTC_576 1073-0113 22.7 µM -0.00609979889362362 0.48957789246623 no 1724 0.497566547409864 553 5439563 SGTC_2628 lathosterol 100 µM -0.00738501868967082 0.489013974874769 no 1725 0.497053830583104 553 6710616 SGTC_2419 paclitaxel 166.5 µM -0.00965036669633633 0.488020059297041 no 1726 0.496150120459822 555 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_661 1304-0007 33.6 µM -0.010778766538207 0.487525004159516 no 1727 0.495699977561558 555 3117130 SGTC_2794 7785382 27.27 µM -0.0123094444209088 0.486853491198157 no 1728 0.495089366184416 552 2205081 SGTC_1633 st005664 67.9 µM -0.0140028164846325 0.486110647317553 no 1729 0.494413867013948 560 2063822 SGTC_366 0181-0206 4.31 µM -0.0140771656174418 0.486078033126512 no 1730 0.494384208924631 556 274874 SGTC_747 3448-8087 38.7 µM -0.0154544976006944 0.485473866036985 no 1731 0.493834792903579 565 5168703 SGTC_2317 5986382 200 µM -0.0157156263020902 0.485359325571215 no 1732 0.493730630275276 554 877883 SGTC_630 4356-0227 183 µM -0.0164907301584493 0.485019344217113 no 1733 0.493421448672914 552 779312 SGTC_117 lucigenin 22.078 µM -0.0168319079113915 0.484869697934933 no 1734 0.493285357333551 563 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3260 9137109 49.47 µM -0.0168548267399297 0.484859645428656 no 1735 0.493276215340709 552 17478346 SGTC_1008 4106-0037 6 µM -0.0170828924452602 0.484759613269914 no 1736 0.493185243386616 558 2905394 SGTC_1346 1488-2224 62.4 µM -0.0173140173292178 0.484658240299885 no 1737 0.493093051534134 558 3722427 SGTC_838 0109-0203 71.4 µM -0.0183296191378035 0.484212802173179 no 1738 0.492687949388859 557 759422 SGTC_226 1,3-diallylurea 8.28947 mM -0.0189448452182256 0.4839429764847 no 1739 0.492442552319841 557 74537 YKL182W FAS1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0192146046501332 0.4838246677774 no 1740 0.492334953463948 558 279621 SGTC_1924 st058459 75.1 µM -0.0196178545487709 0.483647816659816 no 1741 0.492174110351881 564 688683 SGTC_609 0986-0026 86.3 µM -0.0209801520679979 0.483050385232137 no 1742 0.491630744273386 564 2848610 SGTC_2187 6125751 200 µM -0.0213381875894718 0.482893376105133 no 1743 0.491487940737645 564 874498 SGTC_37 0566-0070 1.56 µM -0.0220855346853871 0.482565650956783 no 1744 0.491189862655901 560 1626686 SGTC_1338 1486-1223 76 µM -0.0222507579563129 0.48249319916195 no 1745 0.491123964301592 562 3444526 SGTC_1103 duloxetine 36.1 µM -0.0226440751628452 0.482320728587417 no 1746 0.490967092966962 571 60835 A selective serotonin reuptake inhibitor. SGTC_1862 st057513 3.81 µM -0.0233082385103905 0.482029498832819 no 1747 0.490702200059613 562 5393163 SGTC_2858 9025781 8.96 µM -0.0235555012282477 0.481921078758872 no 1748 0.490603583583873 567 4894980 YPL153C RAD53 SGTC_815 1582-0027 36.9 µM -0.0242682593749909 0.481608555162142 no 1749 0.490319315510188 558 3128206 SGTC_1212 0520-0165 585 µM -0.024725325893964 0.481408150799941 no 1750 0.490137027055606 569 5403258 SGTC_990 3985-0011 41.3 µM -0.0247805649526146 0.481383931123218 no 1751 0.490114996609736 563 5399565 YGL099W LSG1 SGTC_2881 9058953 51.95 µM -0.0252547784770006 0.481176014082818 no 1752 0.489925871980983 554 17122249 SGTC_656 4090-1979 187 µM -0.0259585195688612 0.480867471044672 no 1753 0.48964521194032 561 22330961 SGTC_467 ro 31-8220 72.8 µM -0.0265177104318002 0.480622311702335 no 1754 0.489422203842097 570 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1943 st076331 65.2 µM -0.0268825988742068 0.480462341985282 no 1755 0.489276686294447 560 24208415 SGTC_485 niflumic acid 177 µM -0.0273138404107467 0.480273286653288 no 1756 0.489104708968018 570 4488 A COX2 inhibitor. SGTC_198 3454-2873 16.191 µM -0.0289651613990987 0.479549392596069 no 1757 0.488446188052465 569 710957 SGTC_2777 climbazole 1.536 µM -0.0291916623751219 0.47945010595591 no 1758 0.488355865431172 561 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_706 4262-0057 46.9 µM -0.0296402750687772 0.479253460475405 no 1759 0.488176972276447 568 883298 SGTC_2563 tomatine 8.54 µM -0.0314110873919095 0.478477290028393 no 1760 0.487470849527628 563 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_249 wiskostatin 11.211 µM -0.0317290759994481 0.478337919977755 no 1761 0.487344053630513 569 2775510 A n-wasp and actin depolymerizer. SGTC_1717 st033143 58.0435 µM -0.0317601888332466 0.4783242837909 no 1762 0.487331647658107 559 674616 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0321267723499187 0.47816361884537 no 1763 0.487185476589306 567 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_154 3389-1638 511.116 µM -0.0327097898404474 0.477908103292824 no 1764 0.486953008453118 591 5238686 SGTC_535 2293-4129 48.2 µM -0.0329206500260444 0.477815693103986 no 1765 0.486868932690191 587 396118 YIL048W NEO1 SGTC_1009 4106-0057 9.87 µM -0.0331231403558607 0.477726952155354 no 1766 0.486788194768549 560 2928005 SGTC_3020 9089140 49.47 µM -0.0333677262630549 0.477619764384067 no 1767 0.486690673017505 560 17217859 SGTC_1864 st057645 30.4 µM -0.0334491975766926 0.477584060606984 no 1768 0.486658188799152 563 688666 SGTC_20 0481-0013 4.944 µM -0.0335074892081153 0.477558515144088 no 1769 0.486634946831231 565 182045 SGTC_2118 5526350 200 µM -0.0342822535443573 0.47721899469729 no 1770 0.48632603808566 571 743594 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0343843181276758 0.477174268758796 no 1771 0.486285344199588 581 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_393 acivicin 6.25 µM -0.0353518851912987 0.476750283495983 no 1772 0.485899575380993 562 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1041 0206-0046 107 µM -0.0355883226081959 0.476646681244254 no 1773 0.485805309816684 602 50494 SGTC_3344 9148862 3.898 µM -0.035813599666517 0.476547970711796 no 1774 0.485715494529172 573 4905352 SGTC_1151 3909-8316 15.3 µM -0.0361663256659514 0.476393418269678 no 1775 0.485574868319804 564 800431 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0368508205923879 0.476093506209214 no 1776 0.485301976284477 561 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3056 9094900 49.47 µM -0.0378615363120498 0.47565068502953 no 1777 0.484899040311048 567 25236784 SGTC_2939 9044578 71.43 µM -0.0390714091040051 0.475120647482842 no 1778 0.484416727893348 566 2653634 SGTC_1060 3448-7350 82 µM -0.0391639088831359 0.475080125719961 no 1779 0.484379854043354 575 570178 SGTC_2521 angolensin 13.4 µM -0.0393281042641391 0.475008196601796 no 1780 0.484314399990885 559 821428 A flavenoid. SGTC_1510 1123-0200 71.5 µM -0.0393796424829566 0.474985619407188 no 1781 0.484293855131698 577 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_36 0335-0881 14.2 µM -0.039536578085162 0.474916871588536 no 1782 0.484231295604496 561 23828853 SGTC_2333 9017922 200 µM -0.0395839455418006 0.474896121763374 no 1783 0.48421241350449 571 3163164 SGTC_3318 9139014 38.6185 µM -0.039824230248738 0.474790863506413 no 1784 0.484116629303357 565 16643984 SGTC_1775 st081588 35.1725 µM -0.0407902030891685 0.474367730737839 no 1785 0.483731574831185 566 1426443 YGL099W LSG1 SGTC_2068 5226020 147 µM -0.0408093854097249 0.474359328444551 no 1786 0.483723928559209 571 1810509 SGTC_1055 3448-0672 86 µM -0.0416360785635456 0.47399722890192 no 1787 0.483394405816828 582 748378 SGTC_335 4077-0256 27.6 µM -0.0416400325719407 0.473995497059641 no 1788 0.483392829762519 569 3121989 SGTC_2712 st079126 47.7 µM -0.0446920720240682 0.472658863215243 no 1789 0.482176376496991 582 3152970 SGTC_483 fpl-64176 144 µM -0.0447840449251856 0.472618588591552 no 1790 0.482139721319015 572 3423 SGTC_2399 5884133 200 µM -0.0452258684902179 0.472425119449909 no 1791 0.481963637634213 569 722445 SGTC_2644 guaiazulene 100 µM -0.0453385425412306 0.47237578189871 no 1792 0.481918733252717 571 3515 A coloring agent. SGTC_2353 9059630 146.67 µM -0.0453589111728061 0.472366862956862 no 1793 0.481910615695588 576 4779114 SGTC_2260 7964312 200 µM -0.0466833651157449 0.471786945858214 no 1794 0.481382794302285 586 231951 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0479592505135459 0.471228351223511 no 1795 0.480874359296238 564 6312947 SGTC_2480 5767542 37.17 µM -0.048448587823473 0.471014129700404 no 1796 0.480679368629418 570 2867358 SGTC_681 1642-0006 26.6 µM -0.0487723314800345 0.470872406181966 no 1797 0.480550366102429 560 4446530 SGTC_2709 st078560 56 µM -0.0491284982836138 0.47071649321925 no 1798 0.480408446238403 580 17250903 SGTC_199 4063-0024 41.6 µM -0.0496197814684909 0.470501440073188 no 1799 0.48021269135793 565 306215 SGTC_2322 7413319 38.22 µM -0.0501095055212482 0.470287077979794 no 1800 0.480017562472662 565 1840400 SGTC_2878 9043973 25.97 µM -0.0511216271567197 0.46984407928567 no 1801 0.47961430127215 577 6465167 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0514645898434974 0.469693975310302 no 1802 0.47947765882672 577 147795 SGTC_3052 9092717 49.47 µM -0.0525421187504035 0.469222402936982 no 1803 0.479048367877015 584 25237534 SGTC_3315 9136395 68.55 µM -0.0536824912600554 0.468723374572149 no 1804 0.478594066317676 574 16876844 SGTC_500 h-89 112 µM -0.0536888328245199 0.468720599632661 no 1805 0.478591540042664 577 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1622 st003707 19.4 µM -0.0539659137975478 0.468599356126138 no 1806 0.47848116074938 574 10140899 SGTC_358 0075-0058 9.45 µM -0.0540668150042216 0.468555205076307 no 1807 0.478440965674651 612 1069125 SGTC_3142 9086498 49.47 µM -0.0542105747345691 0.468492301214101 no 1808 0.478383697827553 581 25236367 SGTC_1824 st053723 68.6 µM -0.0553823254409591 0.467979616558403 no 1809 0.4779169382397 588 675225 SGTC_2519 cryptotanshinone 88.04 µM -0.0582202259263243 0.466738150924199 no 1810 0.476786605043773 578 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2237 6667747 47.222 µM -0.0584915912383726 0.466619456432918 no 1811 0.476678530124265 600 729940 YDL015C TSC13 SGTC_750 4073-0104 132 µM -0.0586297598154092 0.466559022991697 no 1812 0.476623503271289 576 22330957 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0586670311911809 0.466542721027028 no 1813 0.47660865969385 575 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2780 5215298 71.43 µM -0.0593913527902358 0.466225924336233 no 1814 0.476320200188428 600 2834131 SGTC_2857 9024691 58.44 µM -0.0597338204538287 0.466076146620054 no 1815 0.476183817495667 596 16478292 SGTC_2347 9049783 174.81 µM -0.0602904231120237 0.465832727546551 no 1816 0.475962164660698 583 6467988 YPL169C MEX67 SGTC_1628 st004252 77.7 µM -0.0605000838487759 0.465741039913446 no 1817 0.475878674536089 573 692968 SGTC_2013 4024628 200 µM -0.0606862213527281 0.465659640849568 no 1818 0.475804552611315 586 5230760 SGTC_3250 9135583 49.47 µM -0.0615832160033284 0.465267399831219 no 1819 0.475447371629614 569 7699353 SGTC_2297 7971671 152.32 µM -0.061766208847898 0.465187384199561 no 1820 0.47537450675948 576 909016 SGTC_1439 4092-1168 46 µM -0.0620479392828085 0.465064197224604 no 1821 0.47526232774602 580 2886240 SGTC_3215 9129942 49.47 µM -0.0622308793867639 0.464984208234027 no 1822 0.475189485971912 568 17682944 SGTC_1645 Cervolide 78 µM -0.0641697671235101 0.464136533807288 no 1823 0.474417525052346 579 23173 A fragrance. SGTC_591 4299-0174 154 µM -0.0651792360015411 0.463695261998596 no 1824 0.474015646619463 582 5509088 SGTC_371 0195-0006 7.36 µM -0.0657529968376589 0.463444472273121 no 1825 0.473787239146816 578 3928593 SGTC_3030 9087619 49.47 µM -0.0663202795483211 0.463196528404619 no 1826 0.473561419011271 575 25236973 SGTC_3334 9142812 21.919 µM -0.0668419013054565 0.46296855431319 no 1827 0.473353782780777 587 45283678 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0669221213068703 0.462933495345987 no 1828 0.473321851128802 574 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1657 st012939 43.4 µM -0.0672810482108547 0.462776635171851 no 1829 0.473178982017176 587 24207257 SGTC_2684 capsaicin 100 µM -0.0677452266479333 0.46257378599061 no 1830 0.472994223162425 578 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1143 3454-2408 5.08 µM -0.0678993752560269 0.462506424134954 no 1831 0.472932868040276 585 X1143 SGTC_2591 skatole 100 µM -0.0679077256542256 0.462502775100461 no 1832 0.472929544384724 585 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3065 9113888 49.47 µM -0.0681581038618979 0.462393363975093 no 1833 0.472829888825677 597 16648368 SGTC_295 k015-0027 31 µM -0.0690039483216082 0.462023765061668 no 1834 0.472493238343427 586 3887424 SGTC_1113 artemisinin 1.17947 µM -0.0695805886833215 0.461771815940649 no 1835 0.47226374373741 598 2240 An anti-malaria and mitochondrial poison. SGTC_1851 st056236 18.9 µM -0.0711091833300088 0.461104007815037 no 1836 0.471655429717273 583 5393171 SGTC_2826 7992541 19.48 µM -0.0717813136459992 0.460810404016524 no 1837 0.471387972001857 582 2985066 SGTC_928 2764-0428 58.7 µM -0.0744432750591989 0.45964780222842 no 1838 0.470328837895203 583 662578 SGTC_79 0052-0007 94.094 µM -0.0782947579032832 0.457966294563063 no 1839 0.468796793625712 574 2801472 SGTC_2404 5161160 200 µM -0.0791459981846282 0.457594754471264 no 1840 0.468458248488482 589 2831543 SGTC_1600 coumarin 106 71.1 µM -0.0808272478389363 0.456861050098024 no 1841 0.467789669158873 597 100336 A hepatotoxic, DNA x-linker. SGTC_1627 st003713 25.6 µM -0.0811338591923383 0.456727259401459 no 1842 0.46766774934886 594 16195070 YER133W GLC7 SGTC_429 1112-0049 25.5 µM -0.0817102909851294 0.456475745114728 no 1843 0.467438547352253 580 2836170 SGTC_1122 capsaicin 818.572 nM -0.0832270344656325 0.455814028513353 no 1844 0.466835508455581 576 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1031 k035-0009 16 µM -0.0840044858526076 0.455474893638877 no 1845 0.466526432591552 603 5180959 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0871904156170003 0.454085489235033 no 1846 0.465260078786739 574 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1206 3978-0017 132 µM -0.0885855004644329 0.4534772596088 no 1847 0.464705665865295 619 3873677 SGTC_2081 5214970 32.255 µM -0.0906362401737256 0.452583375801414 no 1848 0.463890817468463 597 2063512 SGTC_2330 7979373 200 µM -0.0911913834657731 0.452341439078423 no 1849 0.463670260712645 586 1863007 SGTC_2156 5649887 115 µM -0.09120707954371 0.452334598835279 no 1850 0.463664024870203 592 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2408 sulbentine 18.36 µM -0.0912530645510642 0.45231455896582 no 1851 0.463645755691429 593 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2569 tetrandrine 100 µM -0.092970998367754 0.451565985711708 no 1852 0.462963300678314 597 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3272 9137413 49.47 µM -0.0931153050316729 0.45150311326353 no 1853 0.462905979302923 629 17614870 SGTC_1709 st033179 39.1045 µM -0.0940538407021365 0.451094235807278 no 1854 0.462533193776707 597 573381 SGTC_1804 st050076 49.1 µM -0.0948435740511095 0.450750224958947 no 1855 0.46221953787913 590 3895976 SGTC_2923 7992654 58.14 µM -0.0954447347758112 0.45048838184639 no 1856 0.461980792512023 579 2985126 SGTC_919 tnp00227 403.569 nM -0.0962968628980996 0.450117263674978 no 1857 0.461642401277198 613 1269246 A methoxyflavone. YNL221C POP1 SGTC_1562 morin hydrate 59.1 µM -0.0966102580366263 0.449980785023548 no 1858 0.4615179549351 607 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2776 terbinafine 19.92 µM -0.0969200276416213 0.449845891048243 no 1859 0.461394951961847 574 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2258 7960471 200 µM -0.0988971174299708 0.448985073834954 no 1860 0.460609978822502 596 2974708 SGTC_671 0560-0003 407 µM -0.0990421365337296 0.448921942482176 no 1861 0.460552407218723 607 3238678 SGTC_1145 3546-0597 10.2 µM -0.0994810744749126 0.448730866951543 no 1862 0.460378156867595 589 875334 SGTC_3166 9102297 49.47 µM -0.100183877752107 0.448424952107142 no 1863 0.460099172652324 605 25237072 SGTC_1033 k072-0102 21.3 µM -0.100397891111913 0.448331802870307 no 1864 0.460014221978828 589 5965931 SGTC_1208 2323-2347 50.3 µM -0.100733696676805 0.448185649364069 no 1865 0.459880930668097 600 5412760 SGTC_1275 0867-0008 21.1 µM -0.101072636854103 0.448038138704333 no 1866 0.459746399707726 606 3422836 SGTC_1781 st038725 66.3 µM -0.101264874294164 0.447954477953461 no 1867 0.459670099536555 590 4270275 YIL048W NEO1 SGTC_447 ml7 120 µM -0.101638582866812 0.447791848521458 no 1868 0.459521776657821 589 4216 Selective myosin light chain kinase inhibitor. SGTC_1797 st048695 56.8 µM -0.102702486259393 0.447328910218707 no 1869 0.45909955016606 591 592262 YIL048W NEO1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.103236720261064 0.447096474983805 no 1870 0.458887548521122 598 688761 SGTC_3194 9111903 49.47 µM -0.103319336864144 0.447060531663274 no 1871 0.458854764574705 606 17087251 SGTC_2505 galangin 7.89 µM -0.103643314500585 0.446919585597753 no 1872 0.458726206369553 620 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2342 7990637 118.86 µM -0.1074112484094 0.445280847645083 no 1873 0.457231365596728 625 2033102 YER133W GLC7 SGTC_1393 3470-5649 58.2 µM -0.108916725769152 0.444626349902472 no 1874 0.456634270161354 594 4108395 SGTC_2621 lithochol-11-enic acid 100 µM -0.108929693500617 0.444620712907934 no 1875 0.456629127383301 618 6708711 SGTC_2030 5175110 200 µM -0.109248420715455 0.444482167636394 no 1876 0.456502727967171 633 2831986 SGTC_555 4296-0685 37 µM -0.110140676639177 0.444094355365492 no 1877 0.456148904542457 601 2908540 YHR072W ERG7 SGTC_2634 4'-methoxyflavone 100 µM -0.110256841162204 0.444043869266402 no 1878 0.456102842139129 611 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_616 4092-0450 108 µM -0.111959386180529 0.443304033184531 no 1879 0.455427804587611 603 787165 SGTC_3189 9110682 49.47 µM -0.112682980144905 0.442989657178588 no 1880 0.455140947587671 612 17122418 SGTC_533 1222-0222 6.71 µM -0.113087911665795 0.442813744390962 no 1881 0.454980429301808 616 3982874 SGTC_3155 9099265 49.47 µM -0.113173401507819 0.442776606819457 no 1882 0.454946541342931 613 25236499 SGTC_3169 9102970 49.47 µM -0.113326978027085 0.442709893033929 no 1883 0.454885664819738 590 17027839 SGTC_512 prima-1 270 µM -0.115006054532643 0.441980606975993 no 1884 0.454220161533167 593 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2814 7977482 42.97 µM -0.116955119673957 0.44113430143391 no 1885 0.453447809317232 590 6456762 SGTC_2959 9079155 11 µM -0.117639443378704 0.440837224090457 no 1886 0.453176675312885 602 16189457 SGTC_2885 9057732 51.95 µM -0.118013040095781 0.440675053011407 no 1887 0.453028662792336 620 6471414 SGTC_1899 st063254 59.6 µM -0.11823938473103 0.440576806039307 no 1888 0.452938992158262 595 3093813 SGTC_263 alizarin 107.927 µM -0.119313497892745 0.440110627303047 no 1889 0.452513495058406 601 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2739 tacrine 100.86 µM -0.120329595441169 0.439669704473773 no 1890 0.452111030331248 606 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2208 7283366 200 µM -0.12109141014739 0.439339173554693 no 1891 0.451809316409738 597 898663 SGTC_2445 5742597 35.57 µM -0.12170156057041 0.439074476176253 no 1892 0.451567688635255 600 1774255 SGTC_2272 7805186 180 µM -0.123043603189425 0.438492363040376 no 1893 0.451036284963261 603 2956062 YPR165W RHO1 SGTC_2493 resveratrol 26.09 µM -0.124162933922776 0.438006953238817 no 1894 0.450593134766335 593 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2800 7887935 81.82 µM -0.124229715608188 0.437977995584216 no 1895 0.450566697411246 618 2961002 SGTC_1982 st072467 71.9 µM -0.12470453616614 0.437772115041387 no 1896 0.450378733048545 621 3163533 SGTC_1980 st071811 45.7 µM -0.124768302833583 0.437744467317896 no 1897 0.450353490967629 620 4974850 SGTC_446 go6976 132 µM -0.1252857240565 0.437520136926034 no 1898 0.450148676841491 597 3501 A protein kinase C inhibitor. SGTC_783 0848-0141 92.7 µM -0.126906842652469 0.436817423726367 no 1899 0.449507065390477 600 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3047 9092122 49.47 µM -0.128262457504752 0.436229952496592 no 1900 0.448970637113667 626 17173831 SGTC_1005 4092-0690 4.4 µM -0.129168906725732 0.435837210725478 no 1901 0.448611999451302 625 1529343 SGTC_827 3253-0474 693 µM -0.130406281364203 0.435301189449318 no 1902 0.448122498609662 616 5402065 SGTC_1362 1611-0397 101 µM -0.130797148344772 0.435131893504621 no 1903 0.447967889454075 597 27816 SGTC_1010 4112-3296 15.2 µM -0.131154560894863 0.434977098060798 no 1904 0.447826520263484 593 704384 SGTC_1277 0873-0036 22 µM -0.131233742379467 0.434942805892263 no 1905 0.447795202107115 611 5965735 SGTC_2057 5236571 38.335 µM -0.13153654875722 0.434811670061811 no 1906 0.447675438001836 604 54684039 YBR257W POP4 SGTC_917 harmaline 728.087 nM -0.132351436252488 0.434458803808033 no 1907 0.447353162462413 606 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_654 1124-0271 80.9 µM -0.132495035564106 0.434396627190038 no 1908 0.447296374727254 602 5403748 SGTC_3177 9107506 49.47 µM -0.133175157008572 0.434102165596262 no 1909 0.447027428827428 595 8897194 SGTC_2654 protoveratrine a 100 µM -0.133339242701915 0.434031129436451 no 1910 0.446962546742997 611 5702278 A heart drug and vasodilator. SGTC_1309 pyrazolanthrone 13.4 µM -0.134533358450525 0.433514235831767 no 1911 0.446490417308662 620 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.134753239418882 0.433419068930005 no 1912 0.446403489029358 635 165506 SGTC_1202 1988-0068 29.6 µM -0.136058293139085 0.432854306957903 no 1913 0.445887599052203 605 2850480 SGTC_2561 acetosyringone 100 µM -0.136358105125786 0.43272458265417 no 1914 0.4457690957658 606 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2355 9061122 103.12 µM -0.136982092505907 0.432454615617545 no 1915 0.445522474891166 626 5302957 SGTC_2714 st079313 56.9 µM -0.137452202314826 0.432251244258817 no 1916 0.445336685544257 597 2939799 SGTC_1268 0828-0275 2.46 µM -0.137671903274808 0.432156206907573 no 1917 0.445249862927058 626 745337 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.138508282109152 0.431794445504229 no 1918 0.444919362264856 593 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_280 3448-3607 3.04 µM -0.13949461820028 0.431367896158748 no 1919 0.444529654208559 600 626179 SGTC_443 clozapine 122 µM -0.13993749274903 0.431176397335207 no 1920 0.444354688900435 599 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1912 st060209 90.8 µM -0.140300524989962 0.431019434365556 no 1921 0.444211274772941 621 688787 SGTC_1327 1436-0082 2.18 µM -0.140391714236085 0.430980008903857 no 1922 0.444175252050271 615 15992205 SGTC_918 glabranin 770.725 nM -0.141002645187523 0.43071589206445 no 1923 0.443933926332495 629 124049 Also referred to as licorice root. SGTC_732 3970-1727 52.7 µM -0.142664648124221 0.429997534358022 no 1924 0.443277518885254 612 1275699 SGTC_1196 1588-0294 184 µM -0.143382338027487 0.429687402971253 no 1925 0.442994115528393 628 6144269 SGTC_2281 7943571 200 µM -0.143953575416119 0.429440588301879 no 1926 0.442768564577946 604 1244024 SGTC_2629 bisabolol 100 µM -0.144424118899648 0.42923730118218 no 1927 0.442582786167739 613 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1366 1683-0113 21.9 µM -0.144737640486751 0.429101862051947 no 1928 0.442459009625216 622 708623 SGTC_2055 5235184 200 µM -0.145040543464857 0.428971018013694 no 1929 0.442339430583637 628 2836034 SGTC_1548 st061468 90.8 µM -0.145847590870252 0.428622438445888 no 1930 0.44202085273713 603 390799 SGTC_3233 9132340 49.47 µM -0.145941704297942 0.428581792634273 no 1931 0.441983704378992 657 17682950 SGTC_889 0919-1524 82.7 µM -0.146241264872076 0.428452423125889 no 1932 0.441865465526745 628 3905452 SGTC_397 arbidol 50 µM -0.146494934247874 0.428342878397466 no 1933 0.441765344331671 594 131410 A RNA synthesis inhibitor. SGTC_520 3584-0023 682 µM -0.146547199656599 0.428320308759165 no 1934 0.441744716071134 603 1340790 SGTC_21 0849-0113 22.993 µM -0.146605396181266 0.428295178178056 no 1935 0.44172174708676 604 1560156 SGTC_3006 9075424 71.4286 µM -0.147401580932189 0.427951396764497 no 1936 0.441407528875083 610 7465181 SGTC_1178 0988-0033 191 µM -0.14744847047355 0.427931152220409 no 1937 0.441389024835771 608 5392207 SGTC_1084 voriconazole 435 nM -0.147490323548572 0.427913082329246 no 1938 0.441372508447332 625 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_631 k072-0230 41.5 µM -0.148075728655132 0.427660351970552 no 1939 0.4411415019958 638 5773147 SGTC_2873 9040596 71.43 µM -0.149266487545514 0.427146370723771 no 1940 0.44067167902509 621 6463863 SGTC_2159 5658611 73.75 µM -0.149461500085279 0.427062206930951 no 1941 0.440594743285172 643 793844 SGTC_2560 caryophyllene 100 µM -0.149531393852207 0.427032042886354 no 1942 0.440567169559614 606 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3201 9113999 49.47 µM -0.149906668185355 0.426870093087033 no 1943 0.440419125359217 647 16649224 SGTC_1877 wortmannin 25 µM -0.150301842738968 0.426699568663766 no 1944 0.440263239605365 622 312145 A covalent inhibitor of PI 3-kinase. SGTC_1750 st081859 2.357 µM -0.151385370246827 0.426232078808779 no 1945 0.439835864655436 635 5291695 SGTC_880 0833-0487 87.2 µM -0.151822091636298 0.426043683861741 no 1946 0.439663628754797 603 76075 SGTC_203 k066-0004 30.888 µM -0.153292333682527 0.425409568161722 no 1947 0.439083873029948 605 6795412 SGTC_1267 0828-0272 9.49 µM -0.154535202125383 0.424873669128306 no 1948 0.438593878647091 632 745334 SGTC_125 0133-0007 11.75 µM -0.155621255135206 0.424405499257292 no 1949 0.438165784945048 617 26541 SGTC_3347 9188721 44.724 µM -0.15656647864704 0.423998124172818 no 1950 0.437793261415342 621 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1887 st057648 70.8 µM -0.156916642204163 0.423847230288137 no 1951 0.437655271879531 621 688672 SGTC_569 4130-2812 160 µM -0.157067607173005 0.423782179301241 no 1952 0.437595783200995 639 743552 SGTC_1343 1487-0095 224 µM -0.157535078570712 0.423580758493769 no 1953 0.437411582161489 649 4560101 YGL055W OLE1 SGTC_822 1487-0950 154 µM -0.159793377111469 0.422608000738037 no 1954 0.436521920671805 622 1958375 SGTC_1079 idarubicin 2.36 µM -0.160071747435422 0.42248812579776 no 1955 0.436412278225956 639 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_968 1309-0633 340 µM -0.160728422128277 0.422205369662432 no 1956 0.436153651421979 626 3761976 SGTC_1258 0671-0043 57.1 µM -0.161558070523678 0.421848190493468 no 1957 0.435826939157961 661 4298767 SGTC_2332 7982454 138.89 µM -0.162315197778466 0.421522289121616 no 1958 0.435528823641601 628 2981748 SGTC_2556 citropten 84.59 µM -0.162926540755987 0.421259179022338 no 1959 0.4352881367659 603 2775 A potential DNA crosslinker. SGTC_2084 5306078 60.6385 µM -0.163328775589953 0.421086084160169 no 1960 0.435129789227752 644 679340 SGTC_499 genistein 192 µM -0.163615692119521 0.420962623870599 no 1961 0.435016845330204 629 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1458 k015-0034 6.33 µM -0.165497798309015 0.420152946133271 no 1962 0.434276091316924 653 3598957 SGTC_1443 4112-3303 14 µM -0.165657420361776 0.42008429258624 no 1963 0.434213278298981 614 704433 SGTC_1148 3909-7663 27.7 µM -0.167053200248179 0.419484070581347 no 1964 0.433664094628797 667 4084526 SGTC_3165 9101544 49.47 µM -0.167092131674863 0.419467331723937 no 1965 0.433648778497024 635 5002184 SGTC_744 1594-0068 283 µM -0.167680485511751 0.419214382361265 no 1966 0.433417324555981 616 668392 SGTC_1349 flufenamic acid 69 µM -0.167828929574283 0.419150567479965 no 1967 0.433358931390769 633 3371 A non-steroidal anti-inflammatory. SGTC_2686 alizarin 95.37 µM -0.168509023405288 0.418858227954952 no 1968 0.433091422762464 623 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_63 0099-0242 26.702 µM -0.170202553946877 0.418130455896083 no 1969 0.432425421633398 633 3898502 YLR359W ADE13 SGTC_1880 MG-132 525 µM -0.170423132483699 0.418035685798998 no 1970 0.432338690575686 627 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_418 lividomycin a 100 µM -0.170708724777963 0.417912990045139 no 1971 0.432226401077156 617 72394 An antibiotic. SGTC_1704 st028805 70.8 µM -0.171513853223735 0.41756713495889 no 1972 0.431909869271411 617 2876101 SGTC_113 0099-0221 2.5 µM -0.171943358759653 0.417382660428825 no 1973 0.43174102940447 606 89219 SGTC_1673 st016611 27.3 µM -0.172255110184751 0.417248773197505 no 1974 0.431618486826429 656 5226799 SGTC_1934 st074720 32.6 µM -0.172656235446687 0.417076516888806 no 1975 0.431460823055542 613 17250992 SGTC_3295 9122362 53.5725 µM -0.173699947041726 0.416628387655781 no 1976 0.431050639573225 641 4730473 SGTC_902 1120-0002 2.07 µM -0.174763049345095 0.416172044170024 no 1977 0.430632911897137 638 3280475 SGTC_27 0485-0001 32.618 µM -0.175166413292891 0.415998927141213 no 1978 0.430474437288551 621 2054479 SGTC_3129 9127257 49.47 µM -0.176450249942006 0.415448034667455 no 1979 0.429970115077547 677 837894 SGTC_2387 9077560 195.08 µM -0.17668292293162 0.415348212773564 no 1980 0.42987872768109 613 5303272 SGTC_2782 7736369 71.43 µM -0.177293787488323 0.415086164293021 no 1981 0.429638815181313 623 2950836 YOL077C BRX1 SGTC_2641 levomentholum 100 µM -0.17864619963036 0.414506141512156 no 1982 0.429107757956933 618 16666 SGTC_2002 4023503 131 µM -0.17971400782769 0.414048311327111 no 1983 0.428688547918694 658 4736863 YCR052W RSC6 SGTC_629 3448-6466 76.7 µM -0.17989423426073 0.413971049493718 no 1984 0.428617800876714 647 573744 SGTC_3134 9127454 49.47 µM -0.181981679592744 0.413076419389619 no 1985 0.427798551696293 622 24262820 SGTC_633 0437-0093 97.7 µM -0.182069500423978 0.413038791299824 no 1986 0.42776409189244 629 2831118 SGTC_1138 3761-0006 1.03 µM -0.182643771598413 0.412792756318446 no 1987 0.427538768606749 628 12061087 SGTC_1446 4239-0190 62 µM -0.183870032302147 0.412267504267491 no 1988 0.427057707357236 650 1340085 SGTC_1444 4112-3581 28 µM -0.184088812380084 0.412173809292529 no 1989 0.426971891460509 615 2877249 SGTC_306 1672-3436 11.6 µM -0.184994053582714 0.411786183052939 no 1990 0.426616849814959 642 6797378 SGTC_1234 0326-0494 15.5 µM -0.185188710123237 0.411702841932239 no 1991 0.426540511976642 649 1547813 SGTC_662 k832-1615 104 µM -0.186022588475597 0.411345866655106 no 1992 0.426213523725332 625 5878478 SGTC_135 0933-0004 26.348 µM -0.186059314686869 0.411330146203466 no 1993 0.426199123461147 613 21230617 YGL099W LSG1 SGTC_2659 sanguinarine 24.21 µM -0.186691299109587 0.411059651090448 no 1994 0.425951339233048 633 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2200 6600604 21.907 µM -0.187134235366039 0.410870095515731 no 1995 0.425777693164873 665 2904777 SGTC_2890 9046729 58.44 µM -0.187516238819655 0.410706632984901 no 1996 0.425627946384291 638 903329 SGTC_1710 st031758 61.5 µM -0.189662156939352 0.409788665365882 no 1997 0.424786938439655 617 5394341 SGTC_2095 5432005 200 µM -0.190164704750028 0.409573759805029 no 1998 0.424590033970677 630 783734 SGTC_2316 5844804 197.44 µM -0.191022389212362 0.409207049203382 no 1999 0.424254026041134 657 776813 SGTC_426 0988-0037 14.6 µM -0.191022609267134 0.409206955127192 no 2000 0.424253939839154 652 5383008 SGTC_2046 4110841 106 µM -0.191314894183224 0.409082004257924 no 2001 0.424139446369918 657 44119630 YMR134W ERG29 SGTC_2026 5148700 152 µM -0.191868184384129 0.408845499766611 no 2002 0.423922729785997 622 79838 SGTC_2751 anetholtrithion 17.25 µM -0.191890163606733 0.408836105409049 no 2003 0.423914121284698 657 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2232 chlorophetanol 41.5365 µM -0.191961380188687 0.408805666383107 no 2004 0.423886228462146 638 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1723 st034307 2.5525 µM -0.193996522824828 0.407936049295554 no 2005 0.423089302284131 622 867466 SGTC_988 1497-1057 103 µM -0.194672083503214 0.407647482012562 no 2006 0.422824833951551 650 3533044 SGTC_2972 9093619 59.92 µM -0.195308240120067 0.407375792062883 no 2007 0.422575823304471 623 25236256 SGTC_2670 beta-carotene 100 µM -0.195987281494766 0.407085836039137 no 2008 0.422310060423681 631 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2537 larixol 68.93 µM -0.197229619250169 0.406555479910098 no 2009 0.421823926507381 632 6708759 SGTC_1252 0493-0875 34.8 µM -0.197743431051949 0.406336182803014 no 2010 0.421622903765283 634 3960963 SGTC_3191 9110352 49.47 µM -0.198127849024949 0.406172130751338 no 2011 0.421472518169521 623 17122424 SGTC_1707 st032323 6.317 µM -0.198543760811857 0.405994657128636 no 2012 0.42130982498863 637 3132057 YMR211W DML1 SGTC_1502 4534-4282 27.7 µM -0.19975342927411 0.405478589694171 no 2013 0.420836712618293 675 3278949 SGTC_218 alverine citrate 93.75 µM -0.199975702845029 0.405383781425526 no 2014 0.420749791808917 642 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2842 9000675 19.48 µM -0.200518411786905 0.405152318421725 no 2015 0.420537579937176 620 2989072 SGTC_2155 5570423 76 µM -0.200585336516048 0.405123777611735 no 2016 0.420511412403185 660 797402 SGTC_2822 7994718 71.43 µM -0.202895092609464 0.404139066142652 no 2017 0.419608515019941 629 1018011 SGTC_1940 st075990 51.1 µM -0.203180681817473 0.404017353788104 no 2018 0.419496905794209 654 1084979 SGTC_3095 9117207 49.47 µM -0.203723626321823 0.403785987434802 no 2019 0.419284739117152 618 17015229 SGTC_2016 5121758 140 µM -0.204377867504953 0.403507238662405 no 2020 0.419029112165635 659 2795203 SGTC_1022 4477-0945 21.3 µM -0.205194551044467 0.403159347800389 no 2021 0.418710063253789 627 4648966 SGTC_2264 7948757 110.76 µM -0.205994642904491 0.402818598973768 no 2022 0.418397547956844 621 2971411 SGTC_883 0850-0245 24.6 µM -0.206267916205005 0.402702232287123 no 2023 0.418290819394926 624 6823229 YPR165W RHO1 SGTC_384 k007-0144 5.16 µM -0.206329019396972 0.402676214180459 no 2024 0.41826695599159 637 6824886 SGTC_1534 6-azauridine 81.6 µM -0.207505414921304 0.40217538205392 no 2025 0.417807582104938 637 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3059 1327-0034 3 µM -0.207855792008439 0.402026245445352 no 2026 0.417670784046593 634 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2190 6049624 200 µM -0.207919982399828 0.401998924606779 no 2027 0.417645723210503 631 2265554 SGTC_1939 st074455 53.6 µM -0.210738026504359 0.400799976992151 no 2028 0.416545850012397 658 1644229 SGTC_165 k038-0023 64.381 µM -0.211307906561582 0.400557632501945 no 2029 0.416323506837666 640 46368543 SGTC_1131 3454-3128 32.3 µM -0.211492165627544 0.400479283549327 no 2030 0.416251622442038 615 710982 SGTC_213 1246-0773 967 nM -0.21270712642672 0.399962769434509 no 2031 0.41577770394045 651 6251622 SGTC_2229 7354935 190 µM -0.213249748901691 0.399732141778473 no 2032 0.415566083272914 652 318112 SGTC_1207 2099-0101 141 µM -0.21367655681265 0.399550762679831 no 2033 0.415399647039176 648 5837381 SGTC_785 1270-0111 65.3 µM -0.215018622618133 0.398980570977649 no 2034 0.414876399686305 631 6741994 SGTC_1281 0884-0031 11.8 µM -0.21509973374221 0.398946116900861 no 2035 0.414844780744724 631 1548255 SGTC_806 3966-4455 5.86 µM -0.215504424042422 0.398774225853583 no 2036 0.414687031604455 690 714982 SGTC_2343 7990716 14.84 µM -0.216747810394841 0.398246224014393 no 2037 0.414202443131261 611 6456862 SGTC_53 0973-0023 39.979 µM -0.217225249359037 0.398043529830674 no 2038 0.414016404153661 678 674768 SGTC_1691 st019933 84.6 µM -0.217239912982148 0.398037304902349 no 2039 0.41401069062805 662 6176082 SGTC_1247 0448-0043 5.84 µM -0.217643006303578 0.397866195899267 no 2040 0.413853636710838 661 3089013 YGL099W LSG1 SGTC_2566 crystal violet carbinol 226 nM -0.217734762179734 0.397827249209375 no 2041 0.413817888551832 692 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1117 retinoic acid 1.10837 µM -0.217863206538909 0.397772731440097 no 2042 0.413767847731681 662 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1193 1488-0126 41.5 µM -0.218361965915744 0.397561053662655 no 2043 0.413573548641177 621 1384710 SGTC_1395 3486-0190 4.35 µM -0.220256068602393 0.396757455418412 no 2044 0.412835866085232 668 6748079 SGTC_2108 5365811 200 µM -0.22033322369921 0.396724730609799 no 2045 0.412805823549315 629 780283 SGTC_1876 myriocin 605 nM -0.220697270163996 0.396570332598443 no 2046 0.412664078575415 664 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1467 k284-1082 293 µM -0.220703379081553 0.396567741845685 no 2047 0.412661700107022 668 3334705 SGTC_1997 st073024 93.8 µM -0.22164688483134 0.396167661991159 no 2048 0.412294390660646 644 686268 SGTC_2224 6650123 117.647 µM -0.221905082846989 0.396058195923911 no 2049 0.412193886817834 642 2908370 SGTC_752 1896-0090 130 µM -0.222044924489104 0.395998911845838 no 2050 0.412139455718495 641 772567 SGTC_2688 kanamycin b 96.69 µM -0.222049195319001 0.395997101319898 no 2051 0.412137793393566 648 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2916 7875993 68.79 µM -0.222300717311934 0.395890477970579 no 2052 0.412039896869746 675 1299250 SGTC_1387 3342-1166 1.8 µM -0.222788785892728 0.395683601764372 no 2053 0.411849948118684 642 3418228 SGTC_95 0471-0001 561.058 µM -0.222808195951943 0.395675375086353 no 2054 0.411842394450248 634 4015405 SGTC_1568 digitonin 820 nM -0.222920423641463 0.395627809884914 no 2055 0.41179872027527 675 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2852 9023854 51.95 µM -0.224238421386394 0.395069322463558 no 2056 0.411285894317998 670 19798528 SGTC_3012 9080433 71.4286 µM -0.224587314248657 0.394921518878425 no 2057 0.411150167281467 647 17688859 SGTC_1359 1582-0056 520 nM -0.227084558953773 0.393864038702192 no 2058 0.410178995300286 660 3661189 SGTC_599 1935-0052 86.5 µM -0.227582884597456 0.393653111700031 no 2059 0.409985263464558 651 9557311 SGTC_3083 9117465 49.47 µM -0.229238041052867 0.392952755518807 no 2060 0.409341953603494 696 16420915 SGTC_3115 9123671 49.47 µM -0.230084002958261 0.39259493224756 no 2061 0.409013247622785 631 3286988 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.230131931098656 0.392574662412892 no 2062 0.40899462663272 689 61125 An anti-inflammatory. SGTC_1753 st043925 64 µM -0.230810593200942 0.392287673008677 no 2063 0.408730975619043 668 670181 SGTC_25 0118-0223 35.662 µM -0.232063993109532 0.391757795304634 no 2064 0.408244155417272 645 5333628 SGTC_3102 9121669 49.47 µM -0.235256990113895 0.390408857580409 no 2065 0.407004637623418 632 41905072 SGTC_1330 1469-0054 61.8 µM -0.235460694182954 0.390322843775543 no 2066 0.406925591393381 670 7102664 SGTC_3220 9131269 49.47 µM -0.236028288846699 0.390083205923151 no 2067 0.406705359453038 649 17722206 SGTC_1613 st002381 52.1 µM -0.236512199487589 0.389878932352995 no 2068 0.406517620977491 631 551167 SGTC_2248 tofa 1.1 µM -0.237191126181306 0.389592387781662 no 2069 0.406254260099002 659 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3275 9138069 49.47 µM -0.239408580409222 0.388656918430912 no 2070 0.405394388619036 636 17617007 SGTC_2340 7987427 183.45 µM -0.239598781939811 0.388576708777174 no 2071 0.405320654572323 658 2239331 SGTC_2440 5628896 157.78 µM -0.240260393797216 0.388297738277459 no 2072 0.405064198494881 647 5522048 SGTC_1074 carmofur 3.8 µM -0.240588745807741 0.388159309113672 no 2073 0.404936936780218 656 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1854 st056233 32.9 µM -0.240978956835245 0.387994819426579 no 2074 0.404785713001468 683 5393174 SGTC_1745 st081495 74 µM -0.241200035210028 0.387901634889691 no 2075 0.404700041805333 644 13842402 YBL026W LSM2 SGTC_2671 danthron 100 µM -0.24170174387572 0.38769018863639 no 2076 0.404505639102598 656 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_449 xestospongin c 11.1929 µM -0.242187841388054 0.387485353502286 no 2077 0.404317307912459 676 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_264 promethazine 12.5 mM -0.242695557114783 0.387271442171914 no 2078 0.404120624741309 646 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1141 3253-0389 52.6 µM -0.243345952446738 0.38699746692919 no 2079 0.403868704562242 654 5402031 SGTC_1373 2887-0003 58.5 µM -0.244528744162932 0.386499367171587 no 2080 0.403410671448879 643 776948 SGTC_3028 9087778 49.47 µM -0.245316084564777 0.386167904300332 no 2081 0.403105849255579 619 17217395 SGTC_2 0422-0095 29 µM -0.245736953037576 0.385990756702221 no 2082 0.40294293236568 645 6790840 SGTC_346 4513-0042 7.16 µM -0.246262565547907 0.385769554711304 no 2083 0.402739493044564 657 2827372 SGTC_1942 st076330 65.2 µM -0.246423442703674 0.385701857603265 no 2084 0.402677230496272 697 24208414 SGTC_2947 9072639 7.68 µM -0.24675844553596 0.385560899584295 no 2085 0.402547585890905 677 16488146 SGTC_2813 7971799 71.43 µM -0.24683214386776 0.385529891811724 no 2086 0.402519066402086 673 2234054 SGTC_3094 9117742 49.47 µM -0.247505326880805 0.385246691257579 no 2087 0.402258584734168 654 17149698 SGTC_282 k297-0036 65.7 µM -0.248370833235123 0.384882672349797 no 2088 0.401923749186735 672 5061378 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.249807428470763 0.384278686150502 no 2089 0.401368137379595 660 5377381 SGTC_2893 9048488 25.97 µM -0.250057296483143 0.384173663043107 no 2090 0.401271519752525 644 6467338 SGTC_1170 0310-0127 64.8 µM -0.250662860374089 0.383919171150845 no 2091 0.401037388599085 690 774975 SGTC_943 3253-1379 105 µM -0.251055782981058 0.383754069812383 no 2092 0.400885490647417 681 668464 SGTC_734 2023-0417 80 µM -0.251187495662961 0.383698730453146 no 2093 0.400834575863825 687 3935732 SGTC_2954 9074818 52.69 µM -0.251190516240736 0.383697461378883 no 2094 0.400833408250656 694 16648742 SGTC_3312 9133330 71.43 µM -0.251992738300848 0.38336045768952 no 2095 0.400523338361583 687 17617324 SGTC_1771 st048882 4.1505 µM -0.252271584653878 0.383243338394658 no 2096 0.400415575070286 656 4580403 SGTC_3323 9138564 53.9225 µM -0.253687106322083 0.38264896464555 no 2097 0.399868647967481 648 43912313 YNL103W MET4 SGTC_2349 9023730 187.07 µM -0.254490622530355 0.382311693188699 no 2098 0.399558273905014 677 4126287 SGTC_1563 conessine 56.1 µM -0.255565856908269 0.381860509230358 no 2099 0.399143042626345 651 441082 An anti-amoebic, histamine inhibitor. SGTC_2191 5911152 200 µM -0.255832001505245 0.381748855838125 no 2100 0.399040281179543 655 2875902 SGTC_2051 5263410 176 µM -0.25749263021189 0.381052408840928 no 2101 0.398399251898674 636 227584 SGTC_3273 9137859 49.47 µM -0.258423759078921 0.380662073352663 no 2102 0.398039941044264 650 2377234 SGTC_711 k292-0785 179 µM -0.259032607486821 0.380406905645407 no 2103 0.397805040870126 656 4146315 SGTC_3043 9092303 49.47 µM -0.259231495761226 0.38032356305405 no 2104 0.397728315687016 665 25236084 SGTC_1295 1013-0063 9.78 µM -0.259259304247453 0.380311910565826 no 2105 0.397717588314949 664 6826038 SGTC_183 3914-0051 30.55 µM -0.259483587134631 0.380217934099869 no 2106 0.397631072014932 645 1596232 SGTC_2436 5633522 8.09 µM -0.259598955177298 0.3801695966476 no 2107 0.397586571176968 686 5724242 SGTC_1715 st032160 10.2275 µM -0.260392583664212 0.379837129159254 no 2108 0.397280481539057 688 5289825 SGTC_3253 9135987 49.47 µM -0.260994298999769 0.379585117253711 no 2109 0.397048451837713 668 4182430 SGTC_2607 solasodine 47.35 µM -0.263436213480884 0.378562914555597 no 2110 0.39610719085322 655 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2219 9098279 200 µM -0.264286340612027 0.378207244204577 no 2111 0.395779642411964 664 902349 SGTC_1457 k015-0032 57.3 µM -0.265065153141811 0.377881500517392 no 2112 0.39547963560036 661 4302660 SGTC_762 1165-0429 115 µM -0.265519458553633 0.377691524234888 no 2113 0.395304660944432 665 5967793 SGTC_2697 mebhydrolin 72.4 µM -0.265712638530052 0.377610751385486 no 2114 0.395230264526291 665 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2534 helenine 20.12 µM -0.266255105544489 0.377383962475053 no 2115 0.395021373016351 632 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1111 tnp00062 510.699 nM -0.26646466282681 0.377296364284115 no 2116 0.394940685425296 651 676306 SGTC_3103 9120822 49.47 µM -0.267197729605353 0.376989980709134 no 2117 0.394658462068402 675 17141819 SGTC_2862 9027634 71.43 µM -0.267214491384383 0.376982976066952 no 2118 0.39465200959745 650 5012562 SGTC_878 0828-0289 13.7 µM -0.268118275246685 0.37660535046762 no 2119 0.39430413953362 653 745350 YLR208W SEC13 SGTC_1829 berberine 14.4 µM -0.269983169839271 0.375826519995815 no 2120 0.393586600751085 688 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1259 0671-0132 43 µM -0.27083084029125 0.375472676808213 no 2121 0.393260569445173 662 X1259 SGTC_2680 butyl paraben 22.24 µM -0.270896003701843 0.375445479968464 no 2122 0.393235509366368 665 7184 An antifungal and steroid mimetic. SGTC_2525 harmine 47.85 µM -0.2713032906577 0.37527550722304 no 2123 0.393078887886306 668 5280953 A monoamine oxidase inhibitor SGTC_2838 9002687 71.43 µM -0.272913644087175 0.374603697110714 no 2124 0.392459799028451 687 6457060 SGTC_2484 5809818 12.04 µM -0.273790883804138 0.374237888619663 no 2125 0.392122664852438 663 2870548 SGTC_251 melphalan 456.522 µM -0.275035382852563 0.373719127453722 no 2126 0.391644527289131 680 460612 A DNA alkylator. SGTC_2065 5221596 34.26 µM -0.277937538862829 0.372510272938515 no 2127 0.390530153443494 657 788581 SGTC_2943 9068529 45.32 µM -0.280574869700711 0.371412815674085 no 2128 0.389518246569164 658 3270634 SGTC_1953 st076800 12.1 µM -0.280674494653147 0.371371379736259 no 2129 0.389480036501971 658 297591 SGTC_1955 wogonin 32.4 µM -0.282359179658894 0.370670912872419 no 2130 0.388834055962797 663 5281703 A flavanone. SGTC_2773 thioridazine 9.09 µM -0.282462712751923 0.370627879310284 no 2131 0.388794366934026 662 5452 An antipsychotic. SGTC_273 hydroxyurea 18.1 mM -0.282539023609567 0.370596161714825 no 2132 0.388765114191628 669 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1648 st011736 69.8 µM -0.282582040532261 0.37057828268929 no 2133 0.388748624510009 665 2855514 SGTC_3336 9143619 71.43 µM -0.28340152476853 0.370237735746787 no 2134 0.388434529842692 692 45595730 SGTC_2805 7950783 58.44 µM -0.283661608536553 0.370129675923852 no 2135 0.38833485930204 663 1178958 YDL195W SEC31 SGTC_853 0419-0306 21 µM -0.28384942381095 0.370051648648761 no 2136 0.38826288840959 668 762713 SGTC_760 0568-0725 82.9 µM -0.284058112808024 0.369964955723167 no 2137 0.388182923197974 694 3916171 SGTC_1319 1306-0155 43.7 µM -0.284672657955036 0.369709701706552 no 2138 0.387947470034622 652 3122360 SGTC_338 4055-0136 114 µM -0.284746343346242 0.369679100008575 no 2139 0.387919241416891 657 2900563 SGTC_2597 laccaic acid a 100 µM -0.28562821485944 0.369312921016605 no 2140 0.387581445501098 699 5491415 A textile dye. SGTC_3007 9078383 71.4286 µM -0.285814203655323 0.36923570812298 no 2141 0.387510214395779 678 6496995 SGTC_707 0865-0008 204 µM -0.286699501756367 0.368868250670038 no 2142 0.387171209560858 674 723043 SGTC_448 monastrol 171 µM -0.290714985679084 0.367203067362641 no 2143 0.385634654736157 679 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2721 ifenprodil 61.44 µM -0.292111738352164 0.366624430388128 no 2144 0.38510059600265 667 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_637 1181-0519 7.26 µM -0.292446124141851 0.366485948273986 no 2145 0.384972773403169 691 6252091 YGR060W ERG25 SGTC_754 3474-0146 171 µM -0.293160198853863 0.366190280473488 no 2146 0.384699852451967 663 24762078 SGTC_3209 9113616 49.47 µM -0.293368597042261 0.366104006660764 no 2147 0.384620212961716 714 16649353 SGTC_2447 5741742 33.78 µM -0.293511905837525 0.366044682835666 no 2148 0.384565450246399 669 1776504 SGTC_1596 piperlongumine 63 µM -0.293700877353457 0.365966461456521 no 2149 0.384493241917122 678 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1396 3511-0007 98.6 µM -0.294258895643222 0.365735512290705 no 2150 0.384280039696628 688 X1396 SGTC_1603 st002045 67.8 µM -0.295991931046967 0.365018564827307 no 2151 0.383618121772597 680 5887985 SGTC_1175 0741-0056 27.6 µM -0.296053044716872 0.364993291023973 no 2152 0.383594786119166 676 765927 SGTC_1971 st069429 63.5 µM -0.296897935436047 0.364643943227263 no 2153 0.383272216213619 688 1246522 YGL099W LSG1 SGTC_232 clozapine 119 µM -0.298319890682337 0.364056242997785 no 2154 0.382729512244367 672 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1530 rhein 70.4 µM -0.298369692444186 0.364035665499484 no 2155 0.382710509051298 664 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_708 3448-5400 146 µM -0.298724827623502 0.363888939216837 no 2156 0.382575005922262 676 3462195 SGTC_1464 k208-0027 110 µM -0.299188396207915 0.363697443032859 no 2157 0.382398151260465 659 X1464 SGTC_1699 st031318 29.054 µM -0.299513205112091 0.363563287556895 no 2158 0.382274248999829 690 5340658 SGTC_2788 5282734 71.43 µM -0.300352978388133 0.363216514467468 no 2159 0.381953963285017 718 743706 SGTC_1484 3473-2379 286 µM -0.300938032088565 0.362974990630971 no 2160 0.381730874187401 680 671917 SGTC_450 aminopyrene 156 nM -0.300978313412315 0.362958363563326 no 2161 0.381715515803815 685 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2121 5257820 149.641 µM -0.301624512311057 0.362691665039159 no 2162 0.381469159832103 678 791256 SGTC_1465 k213-0056 144 µM -0.301631236918647 0.362688890016171 no 2163 0.381466596404289 667 24048857 YMR208W ERG12 SGTC_1070 indatraline 8.81 µM -0.30172496591696 0.362650211911618 no 2164 0.381430867348344 694 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3140 9094243 49.47 µM -0.302143348275922 0.362477579806791 no 2165 0.3812713942746 701 19291112 SGTC_468 gf-109203x 121 µM -0.30274177725342 0.362230705821554 no 2166 0.381043328618738 685 2396 A protein kinase C inhibitor. SGTC_22 0964-0034 14.468 µM -0.303454006544998 0.36193695969345 no 2167 0.380771946684566 690 138402 SGTC_2018 5133068 143 µM -0.305610184179022 0.361048179436086 no 2168 0.379950732702257 713 785362 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.30579276636908 0.360972953095026 no 2169 0.379881218213813 690 5282362 SGTC_386 1509-0011 3.07 µM -0.306523866910116 0.36067178364997 no 2170 0.379602905325446 698 3107280 SGTC_1078 idebenone 36.1 µM -0.307334938044515 0.360337772220828 no 2171 0.379294222475219 672 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2710 st078562 53.7235 µM -0.307545370659378 0.360251130269538 no 2172 0.379214147192727 709 17250908 SGTC_779 1360-0071 233 µM -0.307796652328403 0.360147678836291 no 2173 0.379118534532919 678 7566 SGTC_979 1426-2828 121 µM -0.310770995225506 0.358923936303911 no 2174 0.3779873605331 697 747872 SGTC_2602 kawain 100 µM -0.31093564543824 0.358856235927799 no 2175 0.377924772764249 692 5369129 SGTC_1590 st077108 57.8 µM -0.3116158977138 0.358576578875029 no 2176 0.3776662254091 680 5489485 SGTC_2201 6605497 169.863 µM -0.31406751124774 0.357569331253253 no 2177 0.376734882114414 711 670741 SGTC_1335 1486-0900 202 µM -0.31484281225211 0.357251004106431 no 2178 0.376440502021163 655 X1335 SGTC_3092 9117248 49.47 µM -0.31495005295649 0.357206980470792 no 2179 0.376399788613438 686 17141857 SGTC_1504 k297-0033 30 µM -0.314986819304248 0.357191887867768 no 2180 0.37638583076625 666 4388117 SGTC_1333 1482-0047 286 µM -0.315185219809743 0.357110448223599 no 2181 0.376310513484923 707 3811116 SGTC_1719 st032227 49.2 µM -0.315266692003292 0.357077007318782 no 2182 0.376279586177053 662 3125804 SGTC_2225 6654152 15.4 µM -0.316167299129146 0.356707419218404 no 2183 0.375937763557614 700 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1898 st060199 18.6 µM -0.317994208272527 0.35595811184364 no 2184 0.37524466509921 660 688866 SGTC_2833 9001315 45.46 µM -0.320471206747966 0.354943058557461 no 2185 0.374305577006339 667 2989378 SGTC_1130 3454-2858 15.9 µM -0.320830619348004 0.354795859572498 no 2186 0.374169377061295 729 715628 YIL048W NEO1 SGTC_1836 st055642 81 µM -0.320996793979733 0.35472780935964 no 2187 0.374106410242871 710 8571 SGTC_115 0527-0192 112.043 µM -0.32215650711966 0.354253024124752 no 2188 0.37366706584724 703 4233931 SGTC_2165 5727197 32.143 µM -0.323250564671251 0.353805325769171 no 2189 0.373252744769123 691 1361712 SGTC_370 0180-0345 38.7 µM -0.323484316449165 0.353709698584983 no 2190 0.373164241632971 674 3989527 SGTC_985 1493-0307 8.71 µM -0.3249422362447 0.353113476290877 no 2191 0.372612395002459 700 3278274 SGTC_1793 st048256 72.231 µM -0.325306256960943 0.352964664694444 no 2192 0.372474647908302 695 672022 SGTC_3149 9097855 49.47 µM -0.326686016289182 0.35240082367716 no 2193 0.371952688919923 670 25236625 YMR079W SEC14 SGTC_1624 st003710 6.25 µM -0.32710302056842 0.352230477905646 no 2194 0.371794983646825 729 24207033 SGTC_2818 7996756 12.99 µM -0.327273387342655 0.35216089180025 no 2195 0.37173055946777 676 2241621 SGTC_2994 9053520 71.4286 µM -0.327311337700782 0.352145391695835 no 2196 0.371716209032673 727 4647384 SGTC_452 diindolylmethane 8 µM -0.327732413840184 0.351973427615934 no 2197 0.371556996524116 703 3071 Inhibits expression of several cancer promoting factors. SGTC_139 0099-0334 718.624 µM -0.33015822372888 0.350983337032946 no 2198 0.370640205588349 693 97690 SGTC_765 1319-0117 244 µM -0.330447888117792 0.350865178387166 no 2199 0.370530781135535 668 3487746 YGL099W LSG1 SGTC_3168 9103419 49.47 µM -0.33114384593648 0.350581345249546 no 2200 0.370267916935495 689 16649256 SGTC_962 1254-0300 21.5 µM -0.331498857056262 0.350436592837073 no 2201 0.370133852083168 684 7340576 SGTC_930 2810-3379 265 µM -0.332850561421889 0.349885647145843 no 2202 0.369623544857023 738 1015764 SGTC_3197 9113331 49.47 µM -0.33335986864006 0.349678138794475 no 2203 0.369431326246352 700 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2830 7992007 71.43 µM -0.334547762001378 0.349194326930663 no 2204 0.368983128034442 689 1952075 SGTC_2345 9052315 157.45 µM -0.334993257193225 0.349012946275431 no 2205 0.368815086317023 678 6469265 SGTC_1933 st074711 15.9 µM -0.33561915502959 0.34875817405822 no 2206 0.368579038716112 681 17250958 SGTC_2327 6189656 200 µM -0.336215235819899 0.348515602279131 no 2207 0.368354282240677 725 5349088 SGTC_137 0438-0332 85.389 µM -0.33623600643008 0.348507150910306 no 2208 0.368346451346925 722 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1109 tnp00067 928.257 nM -0.336974464851893 0.348206727911229 no 2209 0.368068074794071 692 676295 SGTC_3184 9108758 49.47 µM -0.337472125079222 0.348004321221336 no 2210 0.367880510956963 698 902885 SGTC_2727 riluzole 51.77 µM -0.337575002469213 0.347962484674731 no 2211 0.367841741285444 697 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2657 nystatin 74.44 µM -0.337837419592288 0.347855777419953 no 2212 0.367742854656443 699 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3286 9117135 37.221 µM -0.337863176475577 0.347845304490809 no 2213 0.367733149163982 683 3438150 SGTC_55 0767-0285 6.563 µM -0.339057779015829 0.347359698397831 no 2214 0.367283101960725 704 3116166 SGTC_2677 mitomycin C 100 µM -0.340767202273276 0.346665253350497 no 2215 0.366639421499517 682 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2167 5876490 200 µM -0.341603757953063 0.346325594095574 no 2216 0.366324554364538 724 686534 SGTC_3104 9120930 49.47 µM -0.341819791199951 0.346237900101696 no 2217 0.366243257267165 719 17014836 SGTC_2675 theaflavin digallate 100 µM -0.343653665897053 0.345493811003469 no 2218 0.365553380185732 702 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2517 totarol 10 µM -0.34374673782007 0.34545606323799 no 2219 0.365518379448952 702 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1521 st012942 49.4 µM -0.344062948178447 0.345327827296239 no 2220 0.365399473376326 701 24207259 SGTC_2240 6690706 185.951 µM -0.344774332463159 0.345039397446768 no 2221 0.365132015490726 663 805876 SGTC_3074 9116018 49.47 µM -0.345285960517972 0.344832014139427 no 2222 0.364939700142805 702 17027303 SGTC_150 3970-0969 77.2 µM -0.346054909816832 0.344520415928444 no 2223 0.364650724484774 709 6615640 SGTC_2252 omeprazole 400 µM -0.34691935728012 0.344170245325069 no 2224 0.364325951865456 685 4594 A proton pump inhibitor. SGTC_3342 9147791 14.508 µM -0.347000964055775 0.34413719492649 no 2225 0.364295297254701 718 1838168 SGTC_2774 tamoxifen 10.92 µM -0.347438306055392 0.343960093560333 no 2226 0.364131029750997 689 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2743 auranofin 4.32 µM -0.348539261026843 0.34351441414918 no 2227 0.363717616969941 675 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1455 4262-0120 131 µM -0.349352098366671 0.343185507620753 no 2228 0.363412495208602 680 1529587 SGTC_197 4544-0043 41.561 µM -0.349633313525762 0.343071744346695 no 2229 0.363306953211003 693 896523 SGTC_2292 7671323 168.05 µM -0.35096083790705 0.342534897500249 no 2230 0.362808864347929 701 937504 SGTC_2079 5212404 121 µM -0.352327932403203 0.34198238088973 no 2231 0.362296171221161 709 758462 SGTC_1386 3228-0095 33.8 µM -0.353047716616655 0.34169161310823 no 2232 0.362026334089568 732 870181 SGTC_1471 k673-0312 37 µM -0.353727597996607 0.341417050916402 no 2233 0.361771518941314 694 24099884 SGTC_133 0724-0033 378.92 µM -0.356377978471818 0.34034752783728 no 2234 0.36077875942675 697 280309 SGTC_1000 4048-0884 8.67 µM -0.356604151164306 0.340256318378394 no 2235 0.360694084684152 714 13040088 SGTC_3212 9128307 49.47 µM -0.3566499459077 0.340237851708323 no 2236 0.360676940836834 710 27243542 SGTC_3353 9151644 39.2805 µM -0.358067170954206 0.339666547177916 no 2237 0.36014652310455 705 4909158 SGTC_2008 4012253 172 µM -0.358416887317387 0.339525627884351 no 2238 0.36001567786836 687 603940 SGTC_1736 st036774 51 µM -0.358477685485195 0.339501131362486 no 2239 0.359992932105233 740 1272247 SGTC_1014 4130-3005 69.3 µM -0.358634793775575 0.339437833143457 no 2240 0.359934157169991 713 743608 SGTC_872 0588-0139 234 µM -0.359287403487313 0.339174948148382 no 2241 0.35969004833233 671 2047100 SGTC_1028 k015-0029 4.8 µM -0.360411376304051 0.33872237167047 no 2242 0.359269760212772 683 4588309 SGTC_2933 9026794 32.47 µM -0.360795030612307 0.338567943501875 no 2243 0.359126338972751 726 17586027 SGTC_3026 9090633 49.47 µM -0.361384248704307 0.338330824848598 no 2244 0.358906110618821 695 25236842 SGTC_1044 1222-0021 1.78 µM -0.362230384079996 0.337990427270921 no 2245 0.358589937932785 722 4306703 SGTC_1414 3917-0015 5.4 µM -0.362471305639828 0.33789352950093 no 2246 0.358499931260873 723 6618702 SGTC_1293 1000-1278 195 µM -0.363674488588067 0.337409774601785 no 2247 0.358050547946131 729 678847 SGTC_1091 telmisartan 47.6 µM -0.364727783034273 0.336986504731815 no 2248 0.35765730866198 726 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3 0833-0587 95.581 µM -0.365600700736806 0.336635876174049 no 2249 0.357331526071287 695 5382644 SGTC_3319 9138450 16.7555 µM -0.3658652312642 0.336529649091708 no 2250 0.357232820852215 714 2029690 SGTC_3053 9095903 49.47 µM -0.36712166511736 0.336025283291603 no 2251 0.356764133744561 738 17174018 SGTC_3325 9138760 55.175 µM -0.368666435056645 0.33540557625293 no 2252 0.356188185020267 700 43844959 SGTC_2115 tiliquinol 12.7705 µM -0.368838584685372 0.33533654360054 no 2253 0.356124021406128 738 71208 A bioactive hydroxyquinoline. SGTC_3326 9140064 16.379 µM -0.370106807655151 0.334828152870481 no 2254 0.355651454973346 715 1868434 SGTC_92 0063-0024 660.874 µM -0.370984180959222 0.334476618490806 no 2255 0.355324657046377 710 3594437 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.372134501325286 0.334015943101253 no 2256 0.35489635485159 701 5355888 SGTC_471 1-acyl-paf 4 µM -0.372490516405589 0.33387341832708 no 2257 0.354763835822555 693 16759367 SGTC_1689 st020265 53.493 µM -0.373418556481482 0.333502005451617 no 2258 0.354418475318808 721 5758320 YPR016C TIF6 SGTC_473 2-arachidonoylglycerol 10 µM -0.374091908699007 0.333232623845946 no 2259 0.354167969158878 683 5282280 An endocannabinoid. SGTC_1496 4469-0713 57.4 µM -0.374716601434673 0.332982785876892 no 2260 0.353935622125948 734 746691 SGTC_2094 5332512 191.667 µM -0.374971822672774 0.332880734687164 no 2261 0.353840711265293 730 755774 SGTC_171 k064-0041 9.68 µM -0.37504438603288 0.332851722209284 no 2262 0.35381372829222 682 53325 SGTC_557 1315-0110 16.2 µM -0.375801526086029 0.332549060160886 no 2263 0.353532226589754 706 6833801 SGTC_1503 4585-0012 61.3 µM -0.376054222240163 0.332448070716773 no 2264 0.353438292968458 724 2922052 SGTC_2199 6590217 200 µM -0.376615916365021 0.332223634504872 no 2265 0.35322952887955 687 703109 SGTC_2111 5486399 200 µM -0.37792606185151 0.331700373384027 no 2266 0.352742760611475 699 689674 SGTC_1037 k284-1091 78.7 µM -0.378819318911667 0.331343802099001 no 2267 0.352411020159284 708 3334711 SGTC_1777 st045864 34.765 µM -0.380573167631523 0.33064414381478 no 2268 0.351759997362898 721 4691462 SGTC_229 benomyl 22.8748 µM -0.380973856880577 0.330484380796964 no 2269 0.351611323745787 709 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2468 5987765 72.9 µM -0.381263281583141 0.330369000445775 no 2270 0.351503948362456 679 26772094 SGTC_507 nimesulide 162 µM -0.381614475332323 0.33022901726377 no 2271 0.351373672826275 716 4495 A COX2 inhibitor. SGTC_2876 9059903 25.97 µM -0.381706427245675 0.330192369847934 no 2272 0.351339566091146 712 6916095 SGTC_870 0573-2213 57.6 µM -0.381860054816146 0.33013114524639 no 2273 0.35128258533814 701 3916321 SGTC_1996 st072960 66.8 µM -0.382472288788544 0.329887199205682 no 2274 0.351055539828743 679 1719405 SGTC_761 k216-0224 480 µM -0.383709294620165 0.329394532168653 no 2275 0.350596961450611 766 1340404 SGTC_2793 7325131 81.82 µM -0.384768395129724 0.328972955342564 no 2276 0.35020450839247 709 4176441 SGTC_2533 agelasine 13.65 µM -0.38593099627526 0.328510430278998 no 2277 0.349773886956449 719 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_550 4123-0385 25.7 µM -0.386068136380394 0.328455888257289 no 2278 0.34972310370004 736 5731123 SGTC_2344 7990960 76.95 µM -0.386241484867556 0.328386951022408 no 2279 0.349658916254332 729 140813 SGTC_2951 9072950 58.06 µM -0.387477631872672 0.327895529515242 no 2280 0.349201320656074 721 16488155 SGTC_3002 9075603 71.4286 µM -0.388862361110091 0.327345393890928 no 2281 0.348688983288591 691 20105405 SGTC_1071 trifluoperazine 6.31 µM -0.390043023836758 0.326876627271152 no 2282 0.348252366493951 745 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1966 st070145 16.1 µM -0.393079344514993 0.325672351640395 no 2283 0.347130439720937 711 3748532 SGTC_884 0851-0618 334 µM -0.393185032661519 0.325630465910599 no 2284 0.347091411782825 743 9642473 SGTC_2452 5863136 48.41 µM -0.393563989396904 0.325480298017624 no 2285 0.346951486056905 730 2184096 SGTC_3087 9117406 49.47 µM -0.39484237060178 0.324973927319237 no 2286 0.346479611486993 705 42546093 SGTC_842 0271-0008 11.1 µM -0.395801677429191 0.324594155128856 no 2287 0.346125669630665 725 1221709 SGTC_1241 0364-0022 50.8 µM -0.3960749380761 0.324486009534365 no 2288 0.3460248730954 714 4563895 SGTC_1314 1222-0010 41.1 µM -0.396640085371982 0.324262393883624 no 2289 0.345816444145588 722 3526027 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.399786339975142 0.323018654342187 no 2290 0.344656946358855 768 65057 A dermal irritant. YDR527W RBA50 SGTC_2762 leflunomide 42.06 µM -0.401899533366264 0.32218440058148 no 2291 0.343878983083972 717 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1162 k048-0130 20.1 µM -0.402006657149839 0.322142133686801 no 2292 0.343839563476556 739 6797406 SGTC_544 k015-0020 52.4 µM -0.40327076180908 0.321643540799712 no 2293 0.34337452422353 714 3008304 SGTC_2733 amorolfine 100 µM -0.404015540564027 0.321349932623451 no 2294 0.343100645675777 726 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2732 terfenadine 20 µM -0.404673565322713 0.32109061763106 no 2295 0.342858737854264 730 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_430 0958-0115 16.4 µM -0.404846192396546 0.321022603035064 no 2296 0.342795286101941 720 6833180 SGTC_479 n-linoleoylglycine 10 µM -0.405266163767999 0.320857160538047 no 2297 0.342640937645163 743 6433346 An anti-infammatory. SGTC_698 k064-0052 127 µM -0.407454463417944 0.319995683223698 no 2298 0.341837116286577 734 5088751 SGTC_2870 9038528 12.99 µM -0.407688238706313 0.319903709154625 no 2299 0.341751286628702 737 6463316 SGTC_2817 7995342 71.43 µM -0.408698251460314 0.319506467742049 no 2300 0.341380558567122 751 18879975 SGTC_1893 st059353 36.1 µM -0.408737331068168 0.319491101758267 no 2301 0.341366217358097 774 3112488 SGTC_32 0928-0142 34.1 µM -0.409318020869611 0.319262812813323 no 2302 0.341153146166026 730 2244242 SGTC_3285 9112818 20.8695 µM -0.411721118659927 0.31831880236637 no 2303 0.34027192200035 731 17017947 YPR165W RHO1 SGTC_1611 st001856 99.4 µM -0.412971488390289 0.317828084564435 no 2304 0.339813751564044 752 647478 SGTC_3292 9120825 59.784 µM -0.413173549744707 0.317748813928244 no 2305 0.339739732817085 751 24824900 SGTC_2696 st077691 74.316 µM -0.413197168348743 0.317739548665162 no 2306 0.339731081296424 755 757133 SGTC_3274 9138298 49.47 µM -0.414104857559951 0.317383560825135 no 2307 0.339398657749469 729 17015756 SGTC_1838 st055369 84.5 µM -0.414184283424378 0.317352418719039 no 2308 0.339369575509789 683 676036 SGTC_1342 1486-1464 234 µM -0.414503534134437 0.317227256677151 no 2309 0.33925268966827 732 3253938 SGTC_686 1319-0111 510 µM -0.41536811260854 0.316888404207011 no 2310 0.338936223087117 774 4562600 SGTC_2326 6164455 177.58 µM -0.416146291563723 0.316583545397976 no 2311 0.338651478971331 725 2888790 SGTC_3054 9094397 49.47 µM -0.417108284996995 0.316206847738423 no 2312 0.338299602594833 749 2598354 SGTC_2799 7812892 81.82 µM -0.417126482324754 0.316199723860109 no 2313 0.338292947765758 750 20205235 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.417594195858598 0.316016647081543 no 2314 0.338121920561295 740 91467 include heat shock SGTC_1742 st038235 28.8875 µM -0.418452740066978 0.315680705152623 no 2315 0.337808066593979 753 564103 YBR002C RER2 SGTC_3173 9105693 49.47 µM -0.418874607069931 0.31551568751135 no 2316 0.33765388795394 770 17096658 SGTC_1274 0865-0114 173 µM -0.419976512243067 0.31508483948248 no 2317 0.337251306091436 707 870624 SGTC_234 nsc-17383 10.7 µM -0.421986345882695 0.314299636732305 no 2318 0.336517491880631 727 408974 SGTC_3222 9128301 49.47 µM -0.422134536924536 0.314241774578063 no 2319 0.336463410161356 732 4911358 SGTC_290 2043-6722 48.1 µM -0.422692545709479 0.314023937389912 no 2320 0.336259797481283 737 773758 YLR208W SEC13 SGTC_2132 5317594 122.667 µM -0.423916837229685 0.313546221779497 no 2321 0.335813232203068 729 794577 SGTC_1923 st058458 19.1 µM -0.424359226856596 0.31337367924079 no 2322 0.335651925760216 763 3534982 SGTC_252 miconazole 1.30953 nM -0.425230213105873 0.313034093140621 no 2323 0.335334430670334 739 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_801 0866-0028 10.1 µM -0.425594715199441 0.312892025601794 no 2324 0.335201595920263 721 6849771 SGTC_876 0720-0963 56.8 µM -0.426568506687713 0.312512619062721 no 2325 0.334846820181578 770 765861 SGTC_836 0330-0104 1.35 µM -0.426745943609648 0.312443507854828 no 2326 0.334782191490391 707 46494820 SGTC_2035 5154463 94.595 µM -0.428291702825195 0.311841718020756 no 2327 0.33421937946977 759 2769623 SGTC_1990 st072050 59.8 µM -0.428654788787773 0.311700435350669 no 2328 0.334087233595717 712 17233948 SGTC_1713 st033146 12.748 µM -0.431725889306654 0.310506530214013 no 2329 0.332970324364908 765 674619 SGTC_1237 0330-0133 46.1 µM -0.432898875917596 0.310051051393398 no 2330 0.332544118339824 758 X1237 YHR072W ERG7 SGTC_522 1273-0010 11.6 µM -0.434255475521607 0.309524637672265 no 2331 0.332051466174759 743 5705015 SGTC_849 0386-0493 241 µM -0.436041316896853 0.308832256891764 no 2332 0.331403376393843 741 726119 SGTC_2031 5180455 200 µM -0.436306234252495 0.308729604700357 no 2333 0.331307279634372 734 29949 SGTC_2147 5545932 89.7195 µM -0.436690836440539 0.308580602715576 no 2334 0.331167787878977 757 797404 SGTC_2467 5474540 200 µM -0.437458369792241 0.308283340352109 no 2335 0.330889480473993 708 5413519 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.438277524831041 0.307966223766219 no 2336 0.330592558128076 738 4620898 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.439800433061331 0.307377046791469 no 2337 0.330040826983076 731 16725076 SGTC_423 5-fluorouracil 457 µM -0.440300897993252 0.307183537174052 no 2338 0.329859595215775 730 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_570 0987-0065 62.6 µM -0.441075724092736 0.306884049053111 no 2339 0.329579088695661 702 3104428 SGTC_702 1488-0190 94 µM -0.441154588857212 0.306853573227384 no 2340 0.329550543041116 740 949357 SGTC_3011 9081274 71.4286 µM -0.441614666574367 0.306675811338275 no 2341 0.329384034485954 722 6625322 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.443560129487987 0.305924638768675 no 2342 0.3286803185553 727 688662 SGTC_1910 st062352 60.4 µM -0.444009149794624 0.305751380986596 no 2343 0.328517984355831 708 2245730 SGTC_1379 2144-0755 36.5 µM -0.444586627959201 0.305528620704706 no 2344 0.328309256395263 752 5392327 SGTC_2620 irigenin 100 µM -0.444763319231093 0.305460477009599 no 2345 0.328245402503472 744 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2635 hydroquinidine 100 µM -0.445544870668157 0.305159140587293 no 2346 0.327963020344172 743 442912 An experimental heart treatment. SGTC_2459 5811157 9.22 µM -0.446671732674905 0.304724898027089 no 2347 0.327556047207681 729 2870684 YBR192W RIM2 SGTC_305 1682-2595 20.8 µM -0.446817694736744 0.304668670835401 no 2348 0.327503347084972 744 226033 SGTC_834 0312-0008 75.7 µM -0.447590118485701 0.304371196262541 no 2349 0.327224517977283 754 6385573 YIL048W NEO1 SGTC_1650 st011916 45.8 µM -0.44767956177819 0.304336758362761 no 2350 0.327192237009867 765 242528 SGTC_2414 st077232 92.9 µM -0.447882304758103 0.304258703679805 no 2351 0.327119069852432 700 729801 SGTC_766 1391-0721 126 µM -0.448449752952661 0.304040287359214 no 2352 0.326914320917805 762 1020919 YIL115C NUP159 SGTC_367 0335-0881 7.1 µM -0.450491675145411 0.303254910595685 no 2353 0.326177977756885 766 23828853 SGTC_1808 st050063 61.5 µM -0.452514178884757 0.302477898012885 no 2354 0.325449304530523 777 4011993 SGTC_189 3970-0742 2.116 µM -0.452649443704449 0.302425963359345 no 2355 0.325400594703213 757 2891807 SGTC_2676 harmalol 100 µM -0.453032967799949 0.302278731807046 no 2356 0.325262501156194 726 5459187 A monoamine oxidase inhibitor SGTC_318 1488-0629 67.2 µM -0.453494917093982 0.30210143621645 no 2357 0.32509620130509 756 3662576 SGTC_3242 9133940 49.47 µM -0.454108426749476 0.301866044147322 no 2358 0.324875394203248 761 17248444 SGTC_168 3970-0862 530.542 µM -0.455347045154051 0.301391061017661 no 2359 0.32442979290293 752 3135186 SGTC_3143 9086658 49.47 µM -0.455490962186661 0.301335893799708 no 2360 0.324378034064796 721 25236626 SGTC_2296 7971656 126.45 µM -0.455515105437773 0.301326639496191 no 2361 0.324369351431621 737 666570 SGTC_2945 9067681 61.76 µM -0.456407992424977 0.300984478611231 no 2362 0.324048309740938 774 16456930 SGTC_2586 curcumin 80 µM -0.456851600817207 0.300814549757074 no 2363 0.323888856893928 745 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2154 5570129 200 µM -0.457268640680365 0.300654837737644 no 2364 0.323738983440172 768 673366 SGTC_1993 st073995 70.8 µM -0.457784050628472 0.300457506237494 no 2365 0.323553797782042 738 3098394 SGTC_1787 fluconazole 80 µM -0.457879671977795 0.300420902776804 no 2366 0.323519446045412 742 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_50 0929-0078 56.389 µM -0.458500512000113 0.300183296778591 no 2367 0.323296447374894 729 1377751 SGTC_1192 1488-0095 21.4 µM -0.459834719785159 0.299672960600214 no 2368 0.322817429969462 767 915875 SGTC_2936 9038235 15.59 µM -0.461073698424764 0.29919940196138 no 2369 0.322372865528492 732 4749415 SGTC_2130 NSC 7 2.4545 µM -0.461243387448666 0.299134570388621 no 2370 0.322311998272863 746 21448 SGTC_2869 9037858 32.47 µM -0.462402305659676 0.298691963427769 no 2371 0.321896423097984 718 27187042 SGTC_719 2810-4230 27.3 µM -0.462649978098697 0.298597412510477 no 2372 0.321807639376946 743 721079 SGTC_2630 antimycin a 100 µM -0.462887702190574 0.298506672258412 no 2373 0.321722431431269 761 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_694 1315-0438 43.2 µM -0.463781222769677 0.298165724066074 no 2374 0.321402248851471 758 6793154 SGTC_2441 5730946 39.09 µM -0.464453927017238 0.297909151730081 no 2375 0.321161280724973 724 1774275 SGTC_3066 9117245 49.47 µM -0.465069799381541 0.297674343623574 no 2376 0.320940736244306 753 17176980 SGTC_2663 amphotericin b 100 µM -0.465220513355933 0.297616895129119 no 2377 0.320886775043269 744 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.465685777905149 0.297439579551042 no 2378 0.320720216924332 709 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.46608821145375 0.297286248231799 no 2379 0.320576180516153 750 521171 SGTC_472 calcifediol 10 µM -0.466910237540345 0.296973160134941 no 2380 0.320282050232279 735 5283731 A vitamin D metabolite. SGTC_3100 9120536 49.47 µM -0.467177531587924 0.296871387376383 no 2381 0.320186433691708 761 16421196 SGTC_438 sphingosine 6.67 µM -0.471040671476587 0.295402274721065 no 2382 0.318805845543525 735 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_130 0136-0219 337.655 µM -0.472942953190146 0.294680087475979 no 2383 0.318126939623921 794 234244 SGTC_1500 4488-1866 171 µM -0.473574117701031 0.294440650559929 no 2384 0.317901817916834 770 2900003 SGTC_2005 4024620 188 µM -0.47441105869748 0.294123289388124 no 2385 0.317603404290708 753 236743 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.477004042224546 0.293141056244654 no 2386 0.316679621613702 744 442882 SGTC_1344 1488-0097 29.1 µM -0.478154135043906 0.292705883719379 no 2387 0.316270251994697 774 747966 SGTC_596 1155-0152 116 µM -0.4792668666459 0.292285133742657 no 2388 0.315874395115737 739 280313 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.479484137318809 0.292203011431851 no 2389 0.315797125180317 731 6708784 An antioxidant flavonoid SGTC_298 1391-0729 10 µM -0.480552058848257 0.291799522745323 no 2390 0.315417447650957 741 3237558 SGTC_3175 9106517 49.47 µM -0.481634703432395 0.291390736480799 no 2391 0.3150327344883 774 41468073 SGTC_1065 prochlorperazine maleate 2.48 µM -0.482287000135613 0.291144570556161 no 2392 0.314801040416241 776 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_245 methotrexate 289.6 µM -0.482330027140455 0.291128336295013 no 2393 0.314785759898698 729 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_142 0335-0849 62.6745 µM -0.482339053877572 0.291124930524617 no 2394 0.314782554203023 733 3889043 YPR107C YTH1 SGTC_2056 5235370 200 µM -0.483139880085416 0.290822854427728 no 2395 0.314498209653789 750 5511916 SGTC_3078 9116413 49.47 µM -0.484665008971858 0.290247972953736 no 2396 0.313956995631367 738 17177322 SGTC_2476 5806916 10.51 µM -0.486076075079078 0.289716560819954 no 2397 0.313456614573484 738 2870194 SGTC_1776 st049249 45.9 µM -0.486327411088008 0.289621954780803 no 2398 0.313367523769224 746 1822314 SGTC_1150 3909-7983 10.9 µM -0.486382657290618 0.289601161358771 no 2399 0.313347942166987 749 23965914 SGTC_1874 staurosporine 7.6 µM -0.487382389232221 0.289225006001939 no 2400 0.312993685632653 779 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1978 st071761 42 µM -0.488932666104645 0.288642159332207 no 2401 0.312444684049098 730 5147680 SGTC_149 3970-0822 46.1 µM -0.492572591551565 0.287275860993433 no 2402 0.311157309158894 742 3114250 YBL034C STU1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.492839597160555 0.28717575720388 no 2403 0.31106296479985 761 279621 SGTC_2906 7926292 26.41 µM -0.4941291595804 0.286692516504822 no 2404 0.310607482786178 799 2966319 SGTC_2309 7664088 163.95 µM -0.494205706417588 0.286663844058796 no 2405 0.310580455051611 766 704922 SGTC_2949 9072542 2.23 µM -0.49573687681813 0.286090593458105 no 2406 0.310040032793798 777 16457352 SGTC_1235 benzylparaben 21.5 µM -0.495796269932816 0.286068368413552 no 2407 0.310019078417347 773 7180 SGTC_209 4077-0173 175.592 µM -0.496040063898115 0.285977148728878 no 2408 0.309933072378335 739 15993494 SGTC_2664 lyso-paf C-16 73.48 µM -0.496622939971695 0.285759111728811 no 2409 0.309727486556097 769 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_110 0850-0284 111.64 µM -0.497139106273606 0.285566094954134 no 2410 0.309545479567187 751 3906265 SGTC_1296 1068-0102 11.9 µM -0.497495454665411 0.285432877185507 no 2411 0.309419853709637 758 767053 SGTC_2389 9091542 195.52 µM -0.498624389391734 0.285011030181232 no 2412 0.309022009963362 750 3626624 YOL127W RPL25 SGTC_2865 9030313 51.95 µM -0.499000619139813 0.284870511165533 no 2413 0.308889473938521 768 42562754 SGTC_1700 st030840 7.9285 µM -0.499450301008398 0.28470260170135 no 2414 0.308731095269581 758 5499307 SGTC_1519 esterone 74 µM -0.500229887247274 0.284411619219587 no 2415 0.308456608049191 747 698 A steroid. SGTC_1199 1638-0010 4.46 µM -0.500799580043737 0.284199069882798 no 2416 0.30825609061043 759 3111136 SGTC_419 nsc-638432 893 µM -0.500805323887858 0.284196927272056 no 2417 0.308254069213923 751 368090 SGTC_938 3126-1755 342 µM -0.501424344059249 0.283966061122352 no 2418 0.308036255260088 756 1777771 SGTC_2827 7993847 71.43 µM -0.502061457694552 0.283728540694789 no 2419 0.3078121453692 756 2985692 SGTC_2314 7727897 200 µM -0.502597939599746 0.283528610297407 no 2420 0.307623489090381 743 900724 SGTC_2903 5923464 63.88 µM -0.5032560584714 0.283283441768972 no 2421 0.307392128095026 771 2876576 SGTC_2319 6033012 152.6 µM -0.504795447219125 0.282710371819421 no 2422 0.306851256927445 745 847246 SGTC_1962 st076595 64.5 µM -0.507323852426186 0.281770330258539 no 2423 0.305963802550225 764 279619 SGTC_2927 9011802 47.9 µM -0.507626186752915 0.28165802561321 no 2424 0.305857761163001 765 43912568 SGTC_248 streptozotocin 5.23457 mM -0.507796470663447 0.281594781715791 no 2425 0.305798042584166 793 5300 DNA alkylating agent. SGTC_1177 0983-0204 23.6 µM -0.509968091200703 0.280788837253209 no 2426 0.305036908381715 760 766818 SGTC_2914 7968218 45.32 µM -0.511395376482747 0.280259742992329 no 2427 0.304537115886732 759 2977111 SGTC_1747 st037496 66.6 µM -0.511992514627629 0.280038527423535 no 2428 0.304328124175092 773 723305 SGTC_2926 9010726 65.15 µM -0.512274823604251 0.279933972823104 no 2429 0.304229341409743 782 2994293 SGTC_80 0159-0065 512.242 µM -0.512543976797903 0.279834308165072 no 2430 0.304135175287681 729 1548079 SGTC_2661 dactinomycin 12.96 µM -0.51338846957389 0.279521712949219 no 2431 0.303839804801464 753 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_169 k015-0017 16.025 µM -0.513731336940933 0.279394846481724 no 2432 0.30371991976388 815 1840002 SGTC_1845 st056753 3.01 µM -0.514217748783715 0.279214914238729 no 2433 0.303549880015731 740 5375839 SGTC_3290 9121031 71.43 µM -0.514668486172332 0.279048228892428 no 2434 0.303392349296334 744 17014854 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.514915125454907 0.278957040718817 no 2435 0.30330616542626 742 6708514 SGTC_641 4092-0595 30 µM -0.517925601396231 0.277845168833754 no 2436 0.302255089448398 760 786260 SGTC_3340 9146634 11.102 µM -0.518226592634288 0.277734121542331 no 2437 0.30215009145938 759 4907387 SGTC_794 k038-0031 316 µM -0.518906676649788 0.277483292129995 no 2438 0.301912910802003 768 6624242 SGTC_3141 9094609 49.47 µM -0.521935710525733 0.276367466841798 no 2439 0.300857546735083 772 25236309 YDL196W YDL196W SGTC_2064 5220758 200 µM -0.52212183809375 0.276298973637814 no 2440 0.300792751197708 758 788518 SGTC_2287 7945887 168.79 µM -0.525197834896333 0.275168243246519 no 2441 0.299722834940996 761 1245853 SGTC_2689 tacrolimus 100 µM -0.52641630515866 0.27472096685957 no 2442 0.299299494638935 783 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1298 1079-1278 263 µM -0.527339013400146 0.274382497568108 no 2443 0.298979093268095 789 2840950 SGTC_2725 haloperidol 53.21 µM -0.52795367905463 0.274157139235303 no 2444 0.298765743144098 777 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2701 st077767 14.721 µM -0.528880513230646 0.273817501763652 no 2445 0.298444170396257 763 5721188 SGTC_1322 1348-1070 12 µM -0.530943855082085 0.273062140155632 no 2446 0.297728843180027 773 6758089 SGTC_3057 9095946 49.47 µM -0.533055578243089 0.272290137785367 no 2447 0.296997553952583 780 24540043 SGTC_3193 9111931 49.47 µM -0.534252144510057 0.271853179732556 no 2448 0.296583548355991 794 17087244 SGTC_724 3910-0327 137 µM -0.535518649055732 0.271391062239139 no 2449 0.296145632718291 805 2885483 SGTC_2406 ethylparaben 405.7 µM -0.537581792273351 0.270639109276087 no 2450 0.29543290162321 774 8434 A possible steroid mimic. SGTC_3005 9076496 71.4286 µM -0.538737439131799 0.270218366274937 no 2451 0.29503401825733 781 21368410 SGTC_2767 sibutramine 71.45 µM -0.539019263945993 0.270115810326591 no 2452 0.294936781171787 782 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_564 3555-0129 330 µM -0.539286446461297 0.270018600688383 no 2453 0.294844609709146 770 563260 SGTC_2334 9017922 200 µM -0.539882528973619 0.269801789708065 no 2454 0.294639023624916 778 3163164 SGTC_2267 7931562 200 µM -0.540811473094518 0.269464082020568 no 2455 0.294318767012623 748 934880 SGTC_2403 6032726 181.2 µM -0.541420083818668 0.269242943047183 no 2456 0.29410903361871 757 2881040 SGTC_1276 0871-0068 94.2 µM -0.542481220338753 0.268857596465827 no 2457 0.29374352056965 774 3414906 SGTC_2178 5812956 200 µM -0.543068092656723 0.26864459563805 no 2458 0.293541460187809 770 5403383 SGTC_966 1300-0360 30.2 µM -0.544767355056984 0.268028339921579 no 2459 0.292956766739089 791 70588 SGTC_2001 4023502 57.655 µM -0.545825011716436 0.267645129077913 no 2460 0.292593114322659 765 108941 YCR052W RSC6 SGTC_76 0433-0009 400.328 µM -0.545908392600034 0.267614930210243 no 2461 0.292564454526558 810 2841569 SGTC_820 1582-0060 59.9 µM -0.547334939164185 0.26709853015143 no 2462 0.292074322107834 775 3848840 SGTC_879 0831-1030 162 µM -0.548160811490456 0.266799800148444 no 2463 0.291790743950523 783 1549252 SGTC_300 r073-0011 5.04 µM -0.550031807787633 0.266123658738779 no 2464 0.291148778598453 786 2735780 SGTC_322 k048-0136 19.3 µM -0.550106711845797 0.266096607954317 no 2465 0.291123091690563 768 6823282 SGTC_129 0088-0017 176.636 µM -0.550343948283705 0.266010941789743 no 2466 0.291041742996488 787 182446 SGTC_2921 7974240 10.71 µM -0.551372091946572 0.26563984027327 no 2467 0.290689313940258 783 2979074 YDR527W RBA50 SGTC_3113 9123498 49.47 µM -0.551618836428216 0.265550818597414 no 2468 0.290604764102587 793 8897275 SGTC_527 4476-4215 268 µM -0.55234955479529 0.265287275261468 no 2469 0.290354442552947 761 4418754 SGTC_3255 9139072 49.47 µM -0.552485424712086 0.265238286605407 no 2470 0.290307908849348 773 17646060 SGTC_1229 0139-0193 12.2 µM -0.55512174727201 0.264288655873591 no 2471 0.289405694332429 768 3090752 SGTC_1547 harmine 94.2 µM -0.556116467166463 0.263930797809723 no 2472 0.289065619283106 767 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_482 fipronil 114 µM -0.556125518922258 0.263927542505941 no 2473 0.289062525530045 769 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1304 1165-0502 251 µM -0.557247796080188 0.263524094020374 no 2474 0.288679068913192 768 767425 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.557766961701541 0.263337565209757 no 2475 0.288501762892733 770 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2848 9016370 25.97 µM -0.559159578949335 0.262837550857979 no 2476 0.288026408333162 772 7894410 SGTC_1160 4092-0570 10.5 µM -0.560587503482214 0.262325364154665 no 2477 0.287539386228856 789 4994975 SGTC_1215 3852-0577 11.2 µM -0.560963625069149 0.262190537037432 no 2478 0.287411167284349 759 2884876 SGTC_3245 9134821 49.47 µM -0.562388294958782 0.261680162266864 no 2479 0.286925746128674 800 17014901 SGTC_2596 sinensetin 100 µM -0.562830805175745 0.261521740915318 no 2480 0.286775050776788 766 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2139 5578692 56.4705 µM -0.562980382706313 0.261468202385504 no 2481 0.286724121142009 784 650991 YMR113W FOL3 SGTC_160 3453-0671 289.699 µM -0.564494718686433 0.2609264907144 no 2482 0.286208746697344 813 5322268 SGTC_1134 3477-0009 42.5 µM -0.564550693372464 0.260906478391278 no 2483 0.286189705249337 791 3973534 SGTC_781 4335-2806 94.4 µM -0.565817570070445 0.260453750117113 no 2484 0.285758900604373 813 845254 SGTC_672 1441-0018 53.7 µM -0.568697088043563 0.259426238810745 no 2485 0.284780862156052 757 251141 SGTC_383 2324-0395 7.37 µM -0.569229007067688 0.259236661142821 no 2486 0.284600368929409 782 3146421 SGTC_1173 0443-0020 122 µM -0.57079889360928 0.258677566267498 no 2487 0.284067986504501 788 5331295 SGTC_3317 9138495 8.753 µM -0.570828801861602 0.258666920891134 no 2488 0.28405784859633 804 17020139 SGTC_1159 4092-0538 61.2 µM -0.571359614850475 0.258478024018471 no 2489 0.283877949353159 783 717301 SGTC_645 0845-0943 5.41 µM -0.57136047687188 0.258477717314794 no 2490 0.283877657247548 775 1885106 SGTC_2810 7959871 45.46 µM -0.572147269634486 0.258197858307233 no 2491 0.283611103716182 780 2974535 SGTC_475 α-linolenic acid 10 µM -0.576649115448602 0.25659959585257 no 2492 0.282088256497642 780 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2304 7443016 91.4 µM -0.578667504870506 0.255884696105364 no 2493 0.281406773059671 806 939854 SGTC_1032 k061-1018 98.7 µM -0.579348480953844 0.255643733746233 no 2494 0.281177029549924 810 4005393 SGTC_931 2812-0076 566 µM -0.582462039534147 0.25454351711275 no 2495 0.280127751822768 810 3450959 SGTC_2280 7785178 200 µM -0.582811197300724 0.254420292518744 no 2496 0.280010203133774 779 2954328 SGTC_2385 9074692 200 µM -0.582812682397016 0.254419768466037 no 2497 0.280009703207078 768 17046906 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.583959264920297 0.254015337535471 no 2498 0.279623859296216 778 6857784 SGTC_107 0358-0022 2.6945 µM -0.584058755726907 0.253980260325117 no 2499 0.279590391172717 819 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1161 k007-0610 110 µM -0.584386302717774 0.253864795910092 no 2500 0.279480220028814 804 5843850 SGTC_539 4859-0462 2.54 µM -0.585595209271448 0.25343887983863 no 2501 0.279073784266659 780 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_361 000s-0510 1.45 µM -0.585723812097533 0.253393593226238 no 2502 0.279030564769245 787 660 SGTC_420 mitomycin C 81.9 mM -0.587290618964072 0.252842194569478 no 2503 0.278504270224471 781 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1801 st050089 28.441 µM -0.587428651002426 0.252793647922849 no 2504 0.278457928088284 786 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.588583237950463 0.252387765461454 no 2505 0.278070440478577 778 15053 SGTC_888 0916-0002 6.97 µM -0.588666388881002 0.252358547923221 no 2506 0.278042544591042 775 2802138 YIL048W NEO1 SGTC_2524 avocatin b 10.57 µM -0.589094661363904 0.25220808996756 no 2507 0.277898887239529 790 6710748 SGTC_559 1550-0661 158 µM -0.590141660558948 0.251840464174671 no 2508 0.277547840248816 787 5830875 SGTC_2950 9072895 21.46 µM -0.590571140008073 0.251689745801389 no 2509 0.277403903348108 778 17332245 SGTC_2241 6772625 37.8075 µM -0.591770393155035 0.2512691410399 no 2510 0.277002175745025 792 2285411 SGTC_2017 5132927 60.65 µM -0.592163184939444 0.251131461063776 no 2511 0.276870659709971 795 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_161 4065-0411 162.148 µM -0.592985962950075 0.25084319323759 no 2512 0.276595273209272 793 1906281 YLR208W SEC13 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.593286951635165 0.250737782868127 no 2513 0.276494564859977 806 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3135 9127742 49.47 µM -0.595067319525235 0.250114753620232 no 2514 0.275899236303517 797 3643468 SGTC_1106 tegaserod maleate 11.7 µM -0.596315564063751 0.249678428014502 no 2515 0.275482217733986 791 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2497 7-hydroxyflavone 100 µM -0.596346895058629 0.249667481425139 no 2516 0.275471754539017 797 5281894 SGTC_2100 5377183 190 µM -0.596598706272614 0.249579511543907 no 2517 0.275387667602681 772 2844202 SGTC_196 k015-0023 18.111 µM -0.598021004433841 0.24908294308198 no 2518 0.274912959000503 784 5211998 SGTC_740 k014-0057 261 µM -0.599788842674284 0.2484664692448 no 2519 0.274323485023035 796 4012779 SGTC_3339 9145883 14.936 µM -0.600083246344191 0.248363884948978 no 2520 0.274225378712878 796 2030670 SGTC_1146 3579-1023 7 µM -0.600770176090267 0.248124613648463 no 2521 0.27399653544224 821 X1146 SGTC_2140 5586273 200 µM -0.601447810093752 0.24788870076458 no 2522 0.273770881461326 800 854421 SGTC_3107 9121808 49.47 µM -0.602252837000823 0.247608592727583 no 2523 0.273502924802833 745 662681 SGTC_3296 9122258 64.045 µM -0.603065443560406 0.247326018916748 no 2524 0.273232576946802 803 4730474 SGTC_1483 3453-0561 55.9 µM -0.603281307507912 0.247250983907271 no 2525 0.27316078295868 822 4546991 SGTC_1740 st038286 13.222 µM -0.604288438613904 0.246901062793256 no 2526 0.272825945762433 780 716786 SGTC_2804 7954240 19.48 µM -0.605638814423419 0.246432299802467 no 2527 0.272377310989228 793 828705 SGTC_1516 st013856 110 µM -0.60600538192695 0.24630513367054 no 2528 0.272255589696612 792 5281404 A mutagen and neurotoxin. SGTC_299 1273-0059 1.44 µM -0.607475575096772 0.245795461831563 no 2529 0.271767673586807 797 2848077 SGTC_594 1487-1584 10.8 µM -0.608602193010669 0.245405280710367 no 2530 0.271394075263509 821 5013332 SGTC_1605 st000082 49.1 µM -0.609202090830066 0.245197654229946 no 2531 0.271195247311531 791 1114022 SGTC_3224 9130643 49.47 µM -0.609767348750513 0.245002103189108 no 2532 0.271007966759659 812 17644395 SGTC_1024 4507-0395 26 µM -0.609853534382021 0.244972294633644 no 2533 0.270979417512824 768 4201836 SGTC_453 enantio-paf c16 10 µM -0.610052078845399 0.244903632566219 no 2534 0.270913654778875 820 13871343 A lipid and platelet activating factor SGTC_885 0865-0106 16.8 µM -0.610459768615569 0.244762674844095 no 2535 0.27077864302584 814 2793380 SGTC_172 1112-0046 2.638 µM -0.611241559978832 0.244492494652797 no 2536 0.270519836678117 802 2802135 YIL048W NEO1 SGTC_3277 9138724 49.47 µM -0.611368905696709 0.24444850031961 no 2537 0.270477691511851 795 15943418 SGTC_776 4476-4378 112 µM -0.611717467091604 0.244328104063376 no 2538 0.270362351624341 830 2892008 SGTC_442 cape 100 µM -0.612597067328202 0.244024424333334 no 2539 0.270071398923352 790 5281787 SGTC_2572 astragaloside iv 100 µM -0.617359366599443 0.24238379377955 no 2540 0.268498858576043 790 45006101 An anti-inflammatory agent. SGTC_476 mead acid 10 µM -0.617520699356759 0.242328318873905 no 2541 0.268445666235212 805 5312531 An omega 9 fatty acid. SGTC_2867 9039098 71.43 µM -0.617620792412246 0.242293904940304 no 2542 0.268412667640977 786 6463460 SGTC_2472 5377652 49.4 µM -0.618160112993786 0.242108521657348 no 2543 0.268234899998432 830 1610903 SGTC_895 0964-0006 13.7 µM -0.618411805169657 0.242022032611279 no 2544 0.268151958997899 819 6738897 SGTC_3157 9099274 49.47 µM -0.618599501322644 0.241957545443678 no 2545 0.268090115232476 803 17217662 SGTC_2015 5119600 184 µM -0.618943388792953 0.241839419477687 no 2546 0.267976826819327 821 2828786 SGTC_2011 4012611 177 µM -0.620632567948959 0.241259638017947 no 2547 0.267420703087956 798 2049887 SGTC_615 k087-0205 167 µM -0.620700552761784 0.241236319232768 no 2548 0.267398332829782 811 9642773 SGTC_372 0155-0182 15.9 µM -0.622398380226154 0.240654362022665 no 2549 0.266839972629659 785 771486 SGTC_1399 3562-5772 25 µM -0.62241294025931 0.240649374648073 no 2550 0.266835186857495 813 23847490 SGTC_579 4491-1009 110 µM -0.624156065455621 0.240052693593387 no 2551 0.266262548445075 832 1271041 SGTC_1837 st055472 66.5 µM -0.624608859248428 0.23989783194066 no 2552 0.266113901863863 793 676091 SGTC_2430 5571206 200 µM -0.629506201026428 0.238226361150467 no 2553 0.264508855166677 817 1731771 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.630981761556785 0.23772400354534 no 2554 0.264026224888317 806 5379071 SGTC_1965 Pectolinarigenin 58.4 µM -0.632353317476054 0.23725757613467 no 2555 0.263578015476031 813 5320438 An anti-inflammatory. SGTC_2989 9073649 71.4286 µM -0.633056868319266 0.23701851356151 no 2556 0.263348253535234 832 21367202 SGTC_1879 gemcitabine 100 µM -0.633152481257626 0.236986035050388 no 2557 0.263317036659069 819 60750 A nucleoside analog which inhibits DNA replication. SGTC_1305 1181-0477 144 µM -0.634502986006453 0.236527546981638 no 2558 0.262876309360782 818 6252086 SGTC_1888 azatryptophan 97.5 µM -0.634802377020126 0.236425971711835 no 2559 0.262778656406703 788 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1619 st003326 88.7 µM -0.636376103834613 0.235892443803245 no 2560 0.262265656113553 786 2849032 SGTC_2978 9011784 42.97 µM -0.638914397704437 0.235033306703887 no 2561 0.261439310582843 793 2994934 SGTC_332 4112-0506 40.9 µM -0.641159110989652 0.234274980454889 no 2562 0.260709656254764 824 2790355 SGTC_2003 4023581 200 µM -0.64119268748778 0.234263647674947 no 2563 0.260698750020662 803 16641307 SGTC_2728 chlorpromazine 9.18 µM -0.642242758092825 0.233909379772824 no 2564 0.260357787246144 855 2726 A thorazine and dopamine antagonist. SGTC_2984 9022109 38.96 µM -0.642656927215705 0.233769731004757 no 2565 0.260223367819353 839 6459207 SGTC_1137 ixabepilone 100 µM -0.645891468869328 0.23268070547628 no 2566 0.259174822466908 811 154225 A novel microtubule stabilizer. SGTC_2040 5100729 123 µM -0.646709872487879 0.232405607944835 no 2567 0.258909866193012 818 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1424 4048-1941 275 µM -0.647151511418428 0.232257230976382 no 2568 0.258766944847008 814 X1424 SGTC_1265 0819-1001 68.8 µM -0.647965805444148 0.23198379170728 no 2569 0.258503533503409 821 3106768 SGTC_1280 0880-0253 10.1 µM -0.649952939633458 0.231317266717003 no 2570 0.257861310235956 822 6836607 SGTC_701 4424-0219 185 µM -0.651132639134552 0.230922077487645 no 2571 0.25748043437496 820 2911779 SGTC_2864 9034755 47.6 µM -0.651619424401067 0.230759118523042 no 2572 0.25732335689471 805 4930451 SGTC_1233 0325-0408 14.2 µM -0.651746201889851 0.230716688325519 no 2573 0.25728245609094 818 12874 SGTC_186 3455-3465 67.277 µM -0.651922046637539 0.230657843394243 no 2574 0.257225730860469 821 755278 SGTC_1788 fluconazole 20 µM -0.653020191190301 0.230290548529506 no 2575 0.256871630838272 832 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1672 st016598 6.51 µM -0.653464389734117 0.230142071028282 no 2576 0.256728469769665 824 4665860 YNL267W PIK1 SGTC_537 1334-0398 209 µM -0.653471945012653 0.230139546069335 no 2577 0.256726035132818 820 5846986 SGTC_291 SEC14.278 35.5 µM -0.654777619835752 0.229703424992767 no 2578 0.256305470949873 820 1068044 SGTC_2558 carylophyllene oxide 100 µM -0.657020925668195 0.228955198664227 no 2579 0.255583730710948 836 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2993 9054257 71.4286 µM -0.657438052463208 0.228816222235427 no 2580 0.255449645379063 824 6470217 YGL055W OLE1 SGTC_1935 st074532 41.6 µM -0.658197653624587 0.228563263410345 no 2581 0.255205566170679 823 2829742 SGTC_623 k072-0108 16.9 µM -0.658366166603469 0.228507167302264 no 2582 0.255151435188668 814 5382803 SGTC_1526 st051518 75 µM -0.65907513481668 0.228271244358753 no 2583 0.254923760979631 819 673993 SGTC_2216 7189485 200 µM -0.659174970136983 0.228238033217884 no 2584 0.254891708947681 801 731273 SGTC_1540 guanosine 70.6 µM -0.660974993337938 0.227639705067422 no 2585 0.254314175283833 823 6802 Guanosine is a purine nucleoside SGTC_102 gallobenzophenone 83.616 µM -0.660983668508824 0.227636823578352 no 2586 0.254311393535427 812 70837 SGTC_1408 3909-7976 48.8 µM -0.663046959320834 0.226952077655689 no 2587 0.253650239598302 827 24152374 SGTC_2889 9059656 51.95 µM -0.663256372724239 0.226882644459812 no 2588 0.253583186373456 838 3949838 SGTC_394 menadione 8.33 µM -0.66329809407255 0.226868812743591 no 2589 0.253569828498834 825 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1654 st012436 41.8 µM -0.663379173861984 0.226841934037017 no 2590 0.253543870336017 821 4323132 SGTC_1553 gossypol 38.6 µM -0.663485701516682 0.226806621856568 no 2591 0.253509767014429 814 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_804 1595-0054 20.9 µM -0.663793963419471 0.226704455535967 no 2592 0.253411094907066 823 761523 Stimulates phospholipase C. SGTC_1256 0570-0116 285 µM -0.664125857288921 0.226594485982705 no 2593 0.253304880970415 822 410638 SGTC_1963 st076565 50.3 µM -0.664732683501201 0.226393498359412 no 2594 0.253110742673721 843 4914280 SGTC_314 1671-0008 2.74 µM -0.665126164070976 0.226263227023999 no 2595 0.252984900619514 836 3913060 SGTC_2266 7929956 200 µM -0.666340835287485 0.225861347763855 no 2596 0.252596635034964 826 2967153 SGTC_789 1309-1135 70.6 µM -0.666494134548265 0.225810656738908 no 2597 0.252547655757588 812 3092424 SGTC_1575 cyproterone acetate 48 µM -0.667216762211832 0.225571794203951 no 2598 0.252316842849294 834 9880 An androgen receptor antagonist and liver toxin. SGTC_2429 5902844 64.44 µM -0.667788561931494 0.225382888800787 no 2599 0.252134284408203 830 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1995 st072814 61.1 µM -0.668141503406491 0.225266332289505 no 2600 0.25202163560177 818 5769371 SGTC_1507 4075-3230 155 µM -0.670855595633944 0.224371163320337 no 2601 0.251156263174987 822 659771 SGTC_2152 5568786 200 µM -0.672622992799842 0.223789322973482 no 2602 0.250593585038398 833 5399883 SGTC_3243 9134147 49.47 µM -0.674205970816714 0.22326892367315 no 2603 0.250090187068274 836 24282180 SGTC_843 0310-0051 143 µM -0.674507011045196 0.223170035601424 no 2604 0.249994514938456 832 2065037 SGTC_2912 7964298 10.93 µM -0.674557102112274 0.223153583712109 no 2605 0.249978597625064 821 2975850 SGTC_1064 honokiol 6.76 µM -0.674587658824833 0.22314354801719 no 2606 0.249968887958874 828 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.674821447352697 0.223066773708693 no 2607 0.249894606206458 822 140250 A respiratory chain inhibitor. SGTC_2192 5915882 198.485 µM -0.675245466930027 0.222927567411663 no 2608 0.249759912143595 818 2876149 SGTC_995 3931-2021 34.6 µM -0.676259221063428 0.22259495099516 no 2609 0.249438039319572 828 730143 SGTC_1994 st072947 40.9 µM -0.676804937540481 0.222416016646554 no 2610 0.249264862491341 837 5286565 YDL195W SEC31 SGTC_33 0986-0033 35.816 µM -0.677108284379419 0.222316588086914 no 2611 0.249168626523682 796 2848082 SGTC_2836 9010338 19.48 µM -0.67908560481259 0.221669099763542 no 2612 0.248541811464176 815 2994051 SGTC_1325 1431-0015 227 µM -0.679260453804451 0.221611896058973 no 2613 0.248486424394786 811 1103340 SGTC_1292 0kpi-0043 232 µM -0.679865077622475 0.221414151993737 no 2614 0.24829494788083 827 3333905 SGTC_319 1348-1596 45.5 µM -0.679865327874283 0.221414070169011 no 2615 0.24829486864562 835 5380505 SGTC_606 k015-0008 38.6 µM -0.680566497362654 0.22118487698353 no 2616 0.248072915955731 842 1970475 SGTC_920 mycophenolic acid 780.421 nM -0.681016914703524 0.221037719462841 no 2617 0.247930393814331 819 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_395 anisomycin 6.25 µM -0.681051356982693 0.221026469004578 no 2618 0.247919497304107 842 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3235 9132602 49.47 µM -0.681063512925876 0.221022498383592 no 2619 0.24791565158714 827 4912240 SGTC_2880 9042983 58.44 µM -0.681095617917395 0.221012011795667 no 2620 0.247905494839298 839 6464714 SGTC_2982 9019404 25.97 µM -0.68386661436265 0.22010798315426 no 2621 0.247029698722067 799 22333232 SGTC_188 3229-0966 278.469 µM -0.68428881093115 0.219970429333837 no 2622 0.246896405508877 829 5722370 SGTC_2437 5741531 144.16 µM -0.684402097871659 0.219933528259022 no 2623 0.246860645828483 838 2262990 SGTC_2665 lovastatin 100 µM -0.685854090580053 0.21946088377916 no 2624 0.246402561476844 838 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_833 3852-0053 558 µM -0.685905584182581 0.219444132593182 no 2625 0.24638632430019 845 3123681 SGTC_2580 diallyl disulphide 81.36 µM -0.686089245570626 0.219384392395503 no 2626 0.24632841609896 823 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3063 1327-0034 4 µM -0.687477372131266 0.218933173829385 no 2627 0.245890977615513 831 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1487 3970-0795 2.82 µM -0.688123636856959 0.218723284002332 no 2628 0.245687463390836 827 3765103 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.688938714307343 0.218458733438396 no 2629 0.245430917643157 845 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_11 0438-0307 1.3 µM -0.690303213286842 0.218016269255355 no 2630 0.245001763792228 834 4011476 SGTC_1364 1653-0028 37.6 µM -0.690718286583264 0.217881776570865 no 2631 0.244871297612021 817 5718652 SGTC_1102 cgs 12066b 26.1 µM -0.691544532119664 0.217614197696576 no 2632 0.244611702766711 824 6438352 A 5-HT1B full agonist. SGTC_2883 9059145 45.46 µM -0.691603032770049 0.217595259504869 no 2633 0.24459332829691 851 16476510 SGTC_2133 5320837 200 µM -0.691985847455898 0.217471355849819 no 2634 0.244473108379207 833 2841355 SGTC_2188 6126565 140.678 µM -0.692524453802426 0.217297096893966 no 2635 0.244304017244635 824 874518 SGTC_1034 k072-0165 12.7 µM -0.694614612570134 0.216621617836042 no 2636 0.243648426105494 843 5835461 SGTC_385 1494-0393 12.4 µM -0.696145195811475 0.216127748769773 no 2637 0.243168952447675 827 3090647 SGTC_2006 4011487 200 µM -0.696444842447856 0.216031139000632 no 2638 0.243075144274177 840 45595294 SGTC_2019 4016004 108 µM -0.697296487883788 0.215756694641145 no 2639 0.242808632779554 840 45595336 SGTC_1555 citronellol 128 µM -0.698388129345864 0.215405206827157 no 2640 0.242467249009981 833 8842 A terpine precursor. SGTC_1048 3161-0300 24.5 µM -0.699069964613974 0.215185837467366 no 2641 0.242254153940304 821 2165101 SGTC_517 1365-0151 113 µM -0.699135026376138 0.215164911687619 no 2642 0.242233825389876 837 768657 SGTC_7 0192-1582 4.227 µM -0.699285968301741 0.215116368866195 no 2643 0.242186667139714 861 252616 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.69942876705277 0.215070450737406 no 2644 0.242142057614499 857 364106 SGTC_1011 4112-3381 17.4 µM -0.700364041094062 0.214769846302117 no 2645 0.241849993444434 844 2877139 SGTC_1426 4048-4480 71.7 µM -0.700762381316444 0.214641890784804 no 2646 0.241725659191498 834 14224343 SGTC_808 0711-0032 135 µM -0.701490267077691 0.214408192580899 no 2647 0.241498553273255 825 4252555 SGTC_2703 st077852 53.4 µM -0.704295351423881 0.213508964855408 no 2648 0.240624430325964 849 6281836 SGTC_608 k048-0125 159 µM -0.704868963119832 0.213325352819546 no 2649 0.240445893278013 830 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1768 st044301 37.178 µM -0.705000866279375 0.213283143886129 no 2650 0.240404848530966 869 3931349 SGTC_342 k048-0088 23.3 µM -0.705197461291376 0.213220242636587 no 2651 0.240343680487554 838 6820570 SGTC_451 chloral hydrate 100 µM -0.705619690832976 0.213085185417559 no 2652 0.24021233778766 858 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_469 w7 172 µM -0.708197954011055 0.212261568022667 no 2653 0.239411168274934 829 45115570 A P450 inhibitor. SGTC_810 3825-7150 143 µM -0.708507110006077 0.212162934279756 no 2654 0.23931519921974 805 22330411 YGL099W LSG1 SGTC_325 2810-4341 181 µM -0.708526174295499 0.212156852848228 no 2655 0.239309281918508 826 774970 SGTC_1958 st076513 41.9 µM -0.709362572192301 0.211890145619093 no 2656 0.239049753854536 849 732122 YGL099W LSG1 SGTC_1371 2421-0008 32.7 µM -0.712017051046025 0.211044996102623 no 2657 0.23822710870299 842 2827552 SGTC_1678 st019265 80.2 µM -0.71235318613523 0.21093811644814 no 2658 0.238123048378592 829 5367020 SGTC_542 3381-0244 89.3 µM -0.712718299990842 0.21082205848559 no 2659 0.238010045068672 861 1112843 SGTC_2293 7624732 200 µM -0.714160252838176 0.210364074157477 no 2660 0.237564045831558 830 894453 SGTC_3121 9125696 49.47 µM -0.714443421430844 0.210274204530578 no 2661 0.237476515063897 871 1235365 SGTC_387 norethindrone acetate 66.7 µM -0.714706249678617 0.210190810526437 no 2662 0.237395287582063 845 541197 SGTC_2426 5582046 32.21 µM -0.714775322363851 0.210168897354885 no 2663 0.237373943091984 833 2251934 SGTC_2938 9059746 27.26 µM -0.715289187848199 0.210005916685208 no 2664 0.237215184076582 848 6471769 SGTC_2617 dihydrotanshinone i 20.83 µM -0.716260171720733 0.209698156420268 no 2665 0.236915357385734 836 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2757 clomiphene 4.22 µM -0.71727705048314 0.209376133922975 no 2666 0.236601582437725 855 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2366 9070441 60.58 µM -0.717869904001609 0.209188524988311 no 2667 0.236418753131846 830 6837235 SGTC_1390 3413-2614 145 µM -0.719034405412639 0.208820305899955 no 2668 0.23605986059939 861 3421432 SGTC_2695 st077686 51.995 µM -0.719545682412413 0.208658759192217 no 2669 0.235902382894001 845 2876092 SGTC_1209 2323-2347 50.3 µM -0.719660974034478 0.208622341014748 no 2670 0.235866880087344 824 5412760 SGTC_1814 st052110 31.539 µM -0.719689287597628 0.208613397933948 no 2671 0.235858161682653 842 674163 SGTC_1688 st021091 57.6 µM -0.720021219071283 0.208508571398512 no 2672 0.23575596551131 861 3656366 SGTC_1197 1601-0112 267 µM -0.720507420070142 0.208355081429841 no 2673 0.235606316409352 853 7350313 SGTC_2291 7917025 104.35 µM -0.721667378822823 0.207989160534363 no 2674 0.235249501335735 837 2964612 SGTC_3264 9137442 49.47 µM -0.722562007149238 0.207707200166237 no 2675 0.234974508515196 842 17015726 SGTC_1348 1493-0373 93.8 µM -0.723246747238708 0.207491542995058 no 2676 0.234764151654944 861 3010129 SGTC_1 0258-0098 57.368 µM -0.723656043676913 0.207362699329562 no 2677 0.234638462707463 815 6790032 YDR047W HEM12 SGTC_91 0417-1751 58.384 µM -0.725479013484327 0.206789415917564 no 2678 0.234079107580157 843 6795624 SGTC_2587 piperic acid 92.2 µM -0.726224684131671 0.20655518975816 no 2679 0.233850521007158 830 5370536 SGTC_3106 9121286 49.47 µM -0.72762691214614 0.206115155084115 no 2680 0.23342100089825 830 15943471 SGTC_174 3553-0389 74.3 µM -0.727636397762479 0.206112180286665 no 2681 0.233418096825536 836 738071 SGTC_278 4092-0821 23.9 µM -0.72772728686889 0.206083677717076 no 2682 0.23339027165051 840 877900 SGTC_877 0771-0151 33.1 µM -0.728227458783222 0.205926867029468 no 2683 0.233237179841211 842 6166523 SGTC_2977 9011197 71.43 µM -0.728525452773288 0.205833475521871 no 2684 0.233145996825077 848 2704722 SGTC_1626 st003712 1.76 µM -0.728691178903362 0.205781547722154 no 2685 0.233095294942866 864 24207035 SGTC_715 0868-0130 184 µM -0.730596685468047 0.205185044518912 no 2686 0.232512768588715 859 2876258 SGTC_1920 st075728 45.7 µM -0.732369824236517 0.204630901884197 no 2687 0.231971435867959 827 3400306 SGTC_3016 9080866 49.47 µM -0.732427900444799 0.204612766936803 no 2688 0.231953717293321 837 17066299 SGTC_2991 9074669 71.4286 µM -0.733051682289126 0.204418044359106 no 2689 0.231763454097045 845 17333109 SGTC_1244 0416-0015 52.5 µM -0.735615756290259 0.203618790702631 no 2690 0.230982285488817 846 96201 SGTC_231 b-estradiol 524 µM -0.735881774539838 0.20353597634913 no 2691 0.230901324837016 848 450 A steroid. SGTC_786 4544-0069 423 µM -0.736427754733326 0.203366069759925 no 2692 0.23073520951771 849 748821 YLR208W SEC13 SGTC_924 2046-0044 21.3 µM -0.736526047909524 0.203335490355807 no 2693 0.23070531075914 840 3623589 SGTC_504 lovastatin 124 µM -0.736559410730338 0.203325111671229 no 2694 0.230695162968596 859 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_638 3970-0837 4.09 µM -0.73766094479307 0.202982618118742 no 2695 0.230360255317202 839 4118451 YLR208W SEC13 SGTC_1057 3448-5381 134 µM -0.738309253749261 0.202781204360071 no 2696 0.23016327224002 826 5497911 SGTC_1478 0453-0656 35.7 µM -0.738990993780611 0.202569533238263 no 2697 0.229956233100583 858 5258496 SGTC_554 4483-2211 187 µM -0.739120538164334 0.20252932638536 no 2698 0.229916903268864 859 747107 SGTC_2374 9071832 200 µM -0.741214976680755 0.201879935200787 no 2699 0.229281552006665 838 17381698 SGTC_951 1171-0579 82.7 µM -0.741807231165412 0.201696530063001 no 2700 0.229102069361876 860 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2469 5655019 90.81 µM -0.7436179560551 0.201136417010739 no 2701 0.228553818509065 845 2788239 SGTC_3072 9116419 49.47 µM -0.744723093642467 0.200795022730942 no 2702 0.228219567685895 842 17170162 SGTC_1497 4476-2978 41.3 µM -0.744726020069175 0.200794119173893 no 2703 0.228218682947911 837 1528379 SGTC_46 0329-0187a 2.197 µM -0.74500487275813 0.200708032428384 no 2704 0.228134387080236 841 46494817 SGTC_2423 st077119 87.2 µM -0.745698225611709 0.200494078220187 no 2705 0.227924865649295 838 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2354 9060492 162 µM -0.745924973903723 0.200424138166651 no 2706 0.227856369019008 864 6471895 SGTC_1023 4482-3888 16 µM -0.747739918317773 0.199864850505457 no 2707 0.227308524142298 851 3303168 SGTC_3008 9078912 71.4286 µM -0.748072193951074 0.199762559220009 no 2708 0.227208306466764 868 16648731 SGTC_412 gemfibrozil 100 µM -0.7500730175551 0.199147270341122 no 2709 0.226605364659907 837 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_274 sirtinol 40.1 µM -0.750084172527761 0.199143843191702 no 2710 0.226602005678099 839 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1380 2291-0730 164 µM -0.750340960592325 0.199064959852525 no 2711 0.226524689508675 848 2999191 SGTC_225 nsc-122657 1.016 µM -0.752161284763624 0.198506310059905 no 2712 0.225977036351175 860 275685 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.753127493970712 0.198210169161267 no 2713 0.2256866521021 855 16486 A toxic proline analog. SGTC_799 1310-0557 151 µM -0.754527228876635 0.197781626971282 no 2714 0.22526635084587 861 5354492 SGTC_1850 st056238 17 µM -0.755588864927744 0.197456970609973 no 2715 0.224947867061515 847 5393177 SGTC_2526 patulin 37.61 µM -0.755989662566754 0.197334487490198 no 2716 0.224827696819917 861 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1677 st019204 53.9 µM -0.756855368187053 0.197070086104562 no 2717 0.224568258531968 859 3945625 SGTC_3031 9088762 49.47 µM -0.757337694210245 0.196922868488184 no 2718 0.224423786756074 863 205253 SGTC_1179 1021-1431 9.29 µM -0.757797429096619 0.19678260822784 no 2719 0.224286130848616 869 2840958 SGTC_982 1491-0518 27.5 µM -0.758913554022074 0.196442342114375 no 2720 0.223952135189578 860 3091256 SGTC_1640 st009078 66.4 µM -0.759355929754891 0.196307576488376 no 2721 0.22381983436809 855 690618 SGTC_3298 9116858 71.43 µM -0.760537917159931 0.195947770127635 no 2722 0.223466556707647 902 2506942 SGTC_1632 st005650 90 µM -0.764062400471976 0.194877267015054 no 2723 0.222415028721463 863 2759605 SGTC_3314 9135860 59.4275 µM -0.765402850477993 0.194471063000319 no 2724 0.222015848058643 848 25252478 SGTC_2673 kobusone 100 µM -0.76617048425517 0.194238674923619 no 2725 0.221787434094826 880 6710676 An epoxy ketone and protein crosslinker. SGTC_1245 0418-0076 17.2 µM -0.76739900768509 0.193867112431115 no 2726 0.22142215917272 869 6790114 SGTC_1279 0874-0590 65.2 µM -0.769485229144513 0.193237135553162 no 2727 0.220802654934492 858 3523074 SGTC_1449 4112-4002 201 µM -0.770577739432436 0.192907728976341 no 2728 0.220478629975438 875 2059539 SGTC_2058 5236698 133 µM -0.77126654748147 0.192700220462665 no 2729 0.220274478218922 849 766665 SGTC_636 0kpi-0074 126 µM -0.772264518656824 0.192399816350227 no 2730 0.219978887785741 867 616434 SGTC_1770 st043884 66.3 µM -0.773630349739815 0.191989145387264 no 2731 0.219574709556631 886 670149 SGTC_2761 levamisole 97.89 µM -0.776339071310654 0.191176289609168 no 2732 0.21877440467956 850 26879 An alkaline phosphatase inhibitor. SGTC_685 1278-0033 54.9 µM -0.777641646492472 0.190786154400617 no 2733 0.218390151013577 870 3590572 SGTC_1587 estradiol valerate 56.1 µM -0.778768770922194 0.190448963137462 no 2734 0.218057968456551 871 13791 A steroid. SGTC_997 3996-0078 137 µM -0.778893657766421 0.190411624443087 no 2735 0.218021180132359 854 735687 SGTC_3046 9092212 49.47 µM -0.780319949286981 0.189985510435662 no 2736 0.217601286651567 886 25236637 SGTC_2363 9053361 176 µM -0.78236045315774 0.189376916512273 no 2737 0.217001384119174 861 6469797 YMR079W SEC14 SGTC_907 3448-6986 75.5 µM -0.784399741761912 0.188769885408931 no 2738 0.216402794942684 882 590582 SGTC_913 3487-1245 167 µM -0.785375866076684 0.188479749232687 no 2739 0.216116613229692 858 4016153 SGTC_1135 dihydrocapsaicin 536.708 nM -0.786399447785725 0.188175802723525 no 2740 0.215816753445214 897 107982 A Capsaicinoid. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.787384591962863 0.187883555834509 no 2741 0.215528381844379 875 5106787 A p450 inhibitor. SGTC_2651 TUB2.036 5 µM -0.788420900025222 0.187576433633234 no 2742 0.215225274862906 853 15992207 YFL037W TUB2 SGTC_3033 9090887 49.47 µM -0.789038026679934 0.187393688275051 no 2743 0.21504489072877 878 19325384 SGTC_1123 mangostin 811.285 nM -0.790625548634289 0.186924092527929 no 2744 0.214581266737026 813 5281650 An antioxidant. SGTC_3279 9140807 49.47 µM -0.791499895343843 0.186665768285258 no 2745 0.214326168598097 883 45595718 SGTC_1921 5740136 50 µM -0.791760843821579 0.186588714348276 no 2746 0.214250068836719 857 1774243 SGTC_1052 3253-3998 198 µM -0.792005196982279 0.186516578603677 no 2747 0.214178822980036 867 5450317 SGTC_3304 9125678 46.087 µM -0.792156134702111 0.186472028756568 no 2748 0.214134821077337 875 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2020 4017018 200 µM -0.79427785232628 0.185846493294724 no 2749 0.213516847292282 887 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2368 9071271 200 µM -0.795769995563345 0.18540735253587 no 2750 0.213082867187128 884 27209959 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.795866911018346 0.185378852417481 no 2751 0.213054697767988 861 756377 SGTC_355 1311-2252 105 µM -0.797141446196604 0.185004300462687 no 2752 0.212684443931925 887 5338538 SGTC_1831 st055328 12 µM -0.797407564009026 0.184926154899475 no 2753 0.21260718386202 875 1103068 SGTC_1791 st048313 56.1 µM -0.797542827041305 0.184886442739455 no 2754 0.212567920202661 837 1204976 SGTC_1630 st005209 31.3 µM -0.799540036543613 0.184300694772786 no 2755 0.211988670625196 845 3367314 SGTC_2269 7935389 174.42 µM -0.799576923425609 0.184289887342156 no 2756 0.211977981033047 858 97605 SGTC_2512 diallyl trisulfide 49.23 µM -0.80073424590859 0.183951005520736 no 2757 0.211642756223965 908 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_17 0960-0276 49.807 µM -0.802332113997708 0.183483763356457 no 2758 0.211180435302606 865 6821114 SGTC_2598 perillyl alcohol 100 µM -0.8035985996759 0.183113948740057 no 2759 0.210814416054632 885 10819 An apoptosis inducer. SGTC_2784 7567673 72.73 µM -0.805970571890498 0.182422583302927 no 2760 0.210129908750395 865 3471247 SGTC_1545 lovastatin 49.4 µM -0.806123309999564 0.182378120250071 no 2761 0.210085876145482 856 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3029 9088683 49.47 µM -0.806287105560544 0.182330445825999 no 2762 0.21003866183104 848 25236615 SGTC_2457 5731572 11.68 µM -0.806756707704732 0.182193806344707 no 2763 0.209903332877807 867 2865357 SGTC_787 4152-0075 138 µM -0.808308395449535 0.181742769216618 no 2764 0.209456535362494 854 9566539 SGTC_1819 st053448 58.6 µM -0.80880235208006 0.181599334987749 no 2765 0.209314421542196 908 2857616 SGTC_731 3966-0296 387 µM -0.808870616916261 0.181579517941837 no 2766 0.209294785867917 855 660956 SGTC_945 3381-0768 11.3 µM -0.810687207302723 0.181052665319708 no 2767 0.208772660835338 883 1126236 YIL048W NEO1 SGTC_1683 st010134 710 nM -0.81603949632941 0.179505954882246 no 2768 0.207238773252402 904 3818134 SGTC_1435 4092-0789 56.7 µM -0.816330912365068 0.179421980250268 no 2769 0.207155449450651 865 2248285 SGTC_1685 st024049 53.0905 µM -0.817402057217587 0.179113530732398 no 2770 0.206849350219256 875 1941139 SGTC_3223 9129970 49.47 µM -0.818032315076469 0.178932196101159 no 2771 0.206669367687837 897 17248386 SGTC_204 PMA1.184 62.41 µM -0.819501609598609 0.178509906856166 no 2772 0.206250141997427 867 2252213 YGL008C PMA1 SGTC_3249 9135183 49.47 µM -0.819620399219759 0.178475793036843 no 2773 0.206216270448894 850 4902779 SGTC_140 0062-0056 502.533 µM -0.820115594581075 0.178333627846275 no 2774 0.206075106488948 883 3758964 SGTC_1136 pergolide 1.05886 µM -0.820545582939377 0.178210240771823 no 2775 0.20595257740014 870 47811 A dopamine receptor agonist. SGTC_3051 9093778 49.47 µM -0.820578033953102 0.178200930993015 no 2776 0.205943331943024 909 17217378 SGTC_2674 ligustilide 100 µM -0.820899483401736 0.178108727835069 no 2777 0.205851762675708 871 5319022 A signalling regulator. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.821434878739014 0.177955224146024 no 2778 0.205699301631521 884 6708561 SGTC_844 0330-0132 15.3 µM -0.82356998651102 0.177343895521128 no 2779 0.20509196775557 870 2828079 SGTC_2137 5261020 140 µM -0.824091090001595 0.177194893602162 no 2780 0.20494390121878 872 763655 SGTC_2734 clemastine 41.6 µM -0.824943794699382 0.176951245778492 no 2781 0.204701750522134 914 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3036 9090181 49.47 µM -0.825312665169932 0.17684591209947 no 2782 0.204597051610663 888 25236586 SGTC_3181 9108277 49.47 µM -0.825543480250092 0.176780021316135 no 2783 0.204531554070602 896 17097298 SGTC_986 1493-0483 84 µM -0.827278039981984 0.176285353174853 no 2784 0.204039743827091 873 40079 SGTC_524 r073-0010 27.8 µM -0.827341553776371 0.176267256715974 no 2785 0.204021748757055 890 2772106 SGTC_1154 4088-0362 150 µM -0.832488653318894 0.174804645342025 no 2786 0.202566590090182 873 6618304 SGTC_2122 5258151 111.688 µM -0.832819108210688 0.174711006437317 no 2787 0.202473378190916 884 2173356 SGTC_1316 1272-0050 65.9 µM -0.833767592684367 0.174442417326728 no 2788 0.202205980248118 886 7340392 SGTC_577 r071-0003 38.6 µM -0.834149919555926 0.174334225311304 no 2789 0.202098253944055 904 4568517 YMR134W ERG29 SGTC_2228 7354201 200 µM -0.835153631787453 0.174050394716413 no 2790 0.201815606511973 905 753451 SGTC_2428 5615643 7.78 µM -0.838065235058794 0.173228712294641 no 2791 0.200997033291632 878 2253075 SGTC_1646 st011709 75.6 µM -0.838078947359275 0.173224848405117 no 2792 0.200993182909775 886 5757843 SGTC_896 0964-0007 44.5 µM -0.840336188966955 0.172589544886983 no 2793 0.200359958072642 865 6756758 SGTC_2846 9008642 19.48 µM -0.840817322635546 0.172454321530823 no 2794 0.200225140580793 907 2992898 SGTC_1716 st033144 30.6155 µM -0.840941500519523 0.172419432119667 no 2795 0.200190353799733 880 674617 SGTC_2772 vinpocetine 57.06 µM -0.845318903044514 0.1711924206732 no 2796 0.198966404838324 896 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2231 micatex 6.853 µM -0.846329864111866 0.170909838016022 no 2797 0.198684376171837 900 20737 An antifungal of unknown mechanism. SGTC_1960 st011366 51.8 µM -0.84652068962826 0.170856532192689 no 2798 0.19863116847435 887 3972846 SGTC_2233 sulbentine 40.3845 µM -0.847031530036698 0.170713884730089 no 2799 0.198488773628593 868 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_667 1498-1044 59 µM -0.847413077019236 0.170607391007431 no 2800 0.198382459026306 904 6739982 SGTC_642 0335-0876 158 µM -0.848965087009629 0.170174647386496 no 2801 0.197950359815274 888 6812350 SGTC_733 4069-0007 56.1 µM -0.849135425204275 0.170127195223086 no 2802 0.197902970151605 900 5717425 YNL287W SEC21 SGTC_2086 5274770 176.623 µM -0.850120327755005 0.169852991110914 no 2803 0.197629095536015 881 689278 SGTC_700 3453-2283 142 µM -0.850172036205672 0.169838602931647 no 2804 0.197614723154345 883 565664 SGTC_90 0870-0863 4.608 µM -0.850954463033653 0.169620983471499 no 2805 0.197397324464887 905 1738164 SGTC_3241 9133421 49.47 µM -0.851527973287166 0.169461584463706 no 2806 0.197238065518279 919 17018221 SGTC_272 doxorubicin 8.13 µM -0.852620747630489 0.16915812955934 no 2807 0.19693482656909 895 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2310 7668677 200 µM -0.853015791409525 0.169048514905231 no 2808 0.196825273557483 892 2197143 SGTC_1369 1866-0067 208 µM -0.853076007460143 0.169031810482291 no 2809 0.196808577764812 876 3531355 SGTC_1049 3226-0134 66 µM -0.853160129237505 0.169008476191087 no 2810 0.196785255190947 882 5702385 SGTC_2197 6588183 93.1375 µM -0.854691449181073 0.168584069541417 no 2811 0.196360992777141 869 884136 SGTC_567 1080-0542 68.4 µM -0.855019286064108 0.16849329837944 no 2812 0.19627023548785 856 5950415 SGTC_1919 st067113 52.3 µM -0.855218703407449 0.168438099270424 no 2813 0.196215041885332 905 1268243 SGTC_2244 6635614 200 µM -0.857270487677951 0.167870836817384 no 2814 0.19564770738031 897 836499 SGTC_71 0417-1750 47.813 µM -0.860346305617866 0.167022763561331 no 2815 0.194799087318248 860 6811472 SGTC_1634 st006576 41 µM -0.860500222184454 0.166980397961738 no 2816 0.194756680546938 879 3915356 SGTC_268 camptothecin 39.6153 µM -0.860806627335237 0.166896080448109 no 2817 0.19467227715789 909 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_396 dithiazanine 1.25 µM -0.863136582941775 0.166255814718754 no 2818 0.194031188103281 875 10578 An antihelmenthic. SGTC_3101 9120531 49.47 µM -0.863384096076813 0.166187892090898 no 2819 0.193963160339637 902 24824904 SGTC_1337 1486-1011 40.3 µM -0.863650259876493 0.16611487134667 no 2820 0.193890022753033 880 X1337 SGTC_722 3534-0461 190 µM -0.863790312448418 0.166076456928804 no 2821 0.193851545279535 885 658262 SGTC_767 0929-0023 86 µM -0.863817639355218 0.166068962218274 no 2822 0.193844038139095 894 1204563 SGTC_1523 st012844 44.7 µM -0.864708005066242 0.165824888998179 no 2823 0.193599537325842 909 4274103 SGTC_2106 5357045 167.29 µM -0.865168121270773 0.165698849679314 no 2824 0.193473259857674 885 668842 SGTC_1570 verbenone 133 µM -0.865884439634651 0.165502752392562 no 2825 0.193276768529132 905 29025 A natural terpanoid with antifungal properties. SGTC_3161 9100388 49.47 µM -0.867127799654348 0.165162730246296 no 2826 0.192935995139324 898 25236368 SGTC_735 3076-0345 636 µM -0.867534898203954 0.165051499179162 no 2827 0.19282449956216 887 2888990 SGTC_2299 7976368 114.88 µM -0.86766590971969 0.165015713371511 no 2828 0.192788626686335 898 2979718 SGTC_2171 5739187 198.077 µM -0.868018442364859 0.16491944399534 no 2829 0.192692118322869 872 2262761 SGTC_2418 pentamidine 31.67 µM -0.869108808574694 0.164621917794756 no 2830 0.192393809591952 855 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1979 st071809 45.3 µM -0.869919436532123 0.164400948800697 no 2831 0.192172216394086 911 4976333 SGTC_1038 k292-0204 154 µM -0.870373176302801 0.164277347894611 no 2832 0.192048250310491 890 4454212 SGTC_1612 st002233 45.4 µM -0.87049464628264 0.164244269112502 no 2833 0.19201507184544 881 1035021 SGTC_303 1348-1668 34.2 µM -0.87171235545399 0.16391290048338 no 2834 0.191682659088187 896 5380509 SGTC_1659 st012954 42.1 µM -0.871760920474437 0.163899693748381 no 2835 0.191669409021153 890 24207262 SGTC_2356 9061756 188.97 µM -0.872997130426829 0.163563752249924 no 2836 0.191332320908672 879 20104043 SGTC_1928 4'-methoxychalcone 40.3 µM -0.873259466251931 0.163492519733241 no 2837 0.191260834280644 878 641818 SGTC_363 0455-0021 3.06 µM -0.873338456544915 0.163471075304491 no 2838 0.191239312598473 883 4597466 SGTC_976 1348-1067 47.6 µM -0.875940630256739 0.162765653867839 no 2839 0.190531155009104 897 5310671 YGL099W LSG1 SGTC_2655 perillic acid 100 µM -0.876924198256681 0.162499535471823 no 2840 0.19026390586554 902 5702197 An apoptosis inducer. SGTC_1429 4049-0205 9.46 µM -0.876956866607583 0.162490701442874 no 2841 0.190255033372111 877 22774478 SGTC_2992 9074591 71.4286 µM -0.877906584783785 0.162234019520559 no 2842 0.189997207736502 905 17741321 SGTC_887 0885-0007 9.62 µM -0.880145965489226 0.161629824052069 no 2843 0.18939012052383 900 5719458 SGTC_2681 menadione 3.18 µM -0.881228382655718 0.161338309300957 no 2844 0.189097110024302 911 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1230 0170-0365 3.77 µM -0.881537331401434 0.161255166696831 no 2845 0.189013528793141 869 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2255 7941087 197.44 µM -0.882687886842958 0.160945781386826 no 2846 0.188702464312371 909 935561 SGTC_3167 9103034 49.47 µM -0.882731175408468 0.160934148623742 no 2847 0.188690766966905 889 5127859 SGTC_2390 9097792 176.6 µM -0.883067970019566 0.160843661900843 no 2848 0.188599774299988 884 4497149 SGTC_2875 9039966 71.43 µM -0.883774685532152 0.160653896399648 no 2849 0.188408927113088 909 6463691 SGTC_1490 4089-0339 670 nM -0.884391143792442 0.160488486004388 no 2850 0.188242551031211 881 742542 SGTC_152 4469-0003 551.229 µM -0.885834618359944 0.160101602940984 no 2851 0.18785332609364 878 697280 SGTC_1352 1496-0991 99 µM -0.886918564595621 0.159811482620025 no 2852 0.187561372954197 919 3000039 SGTC_89 0302-0250 142.109 µM -0.888626594359964 0.15935502352034 no 2853 0.187101896744912 918 4203518 YLR208W SEC13 SGTC_647 0140-0236 81 µM -0.889502333483014 0.159121319697528 no 2854 0.186866584839441 908 990837 SGTC_782 0083-0095 30.5 µM -0.889657923910037 0.159079821611879 no 2855 0.186824796716844 907 3591729 An indicator and reagent. SGTC_2462 5162487 171.77 µM -0.890647831576434 0.158815965826703 no 2856 0.186559065042137 898 2259986 SGTC_1053 3366-3204 134 µM -0.890852340397307 0.158761490622371 no 2857 0.186504195702443 916 3632071 YPR165W RHO1 SGTC_1884 5633444 25 µM -0.892268840613166 0.158384512428109 no 2858 0.186124425713183 890 5724239 SGTC_921 1561-0023 372 µM -0.892332218935918 0.158367659067989 no 2859 0.186107444914108 880 24050882 SGTC_1992 st073643 23.3 µM -0.895317072667546 0.157575268856327 no 2860 0.185308808199788 913 3161292 SGTC_805 3852-0218 479 µM -0.895560991699432 0.157510630921652 no 2861 0.185243638654055 890 6615355 SGTC_2988 9073640 71.4286 µM -0.896935145132088 0.157146809320993 no 2862 0.184876762518278 902 9102229 SGTC_2645 abamectin 100 µM -0.904212385268927 0.155229303129304 no 2863 0.182941397042949 859 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_531 3788-1495 174 µM -0.905442648152507 0.154906669365279 no 2864 0.182615465232241 878 2896655 SGTC_3229 9132204 49.47 µM -0.905652477676609 0.154851686273618 no 2865 0.182559911612092 922 17682924 SGTC_3023 9089636 49.47 µM -0.906043699761823 0.154749206055034 no 2866 0.182456361416434 927 17249241 SGTC_1093 fluphenazine 7.97 µM -0.906384625431323 0.154659937476805 no 2867 0.182366153797808 920 6602611 An atypical antipsychotic. SGTC_3110 9122132 49.47 µM -0.907658210988052 0.154326760645155 no 2868 0.182029414510499 887 918317 SGTC_93 0109-0045 59.227 µM -0.907921334048237 0.154257985436807 no 2869 0.181959892586021 914 88733 SGTC_670 4204-0025 119 µM -0.908810244565913 0.154025791583908 no 2870 0.181725148991141 906 719039 SGTC_2495 cafestol 54.53 µM -0.912337655693141 0.153106670981838 no 2871 0.180795498770993 910 16667697 An anti-infammatory. SGTC_2043 5101342 149 µM -0.919370413414365 0.151285049232214 no 2872 0.178950929604473 916 678451 SGTC_983 1491-0821 12.2 µM -0.919649236879489 0.151213126830417 no 2873 0.178878044000213 903 46495113 SGTC_593 1203-0218 61.7 µM -0.921940633123617 0.150622923735189 no 2874 0.178279771460778 918 3666956 SGTC_3294 9122953 26.2835 µM -0.927723207212265 0.149140314906877 no 2875 0.176775583558824 917 16459826 SGTC_328 k915-0120 63.5 µM -0.928414723312074 0.148963670058884 no 2876 0.176596242043459 907 6624543 SGTC_1901 st060216 58.6 µM -0.930801935404528 0.148354941426123 no 2877 0.175978014188362 902 688792 SGTC_1722 st034304 3.6505 µM -0.933986063488999 0.147545595867456 no 2878 0.175155540986987 933 4036148 YLR033W RSC58 SGTC_987 1497-1013 404 µM -0.934181224839765 0.147496085904398 no 2879 0.175105209443095 907 1676435 SGTC_906 1165-0455 526 µM -0.934989088842814 0.147291259448213 no 2880 0.174896961274457 916 3252859 SGTC_1999 st074831 12.5 µM -0.935295619329832 0.147213591389579 no 2881 0.174817986138059 919 17112523 SGTC_566 0958-0068 16.5 µM -0.935870640844863 0.147067967698699 no 2882 0.174669897496199 890 6815365 SGTC_639 0833-0042 114 µM -0.938882343611672 0.146306834767425 no 2883 0.173895577687407 934 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1694 st024011 44.9 µM -0.939418671077293 0.146171569308997 no 2884 0.173757915255135 910 2787533 SGTC_175 3793-3120 23.7 µM -0.940868122040265 0.145806428214187 no 2885 0.173386222802887 914 5322297 SGTC_1356 1502-0781 85.8 µM -0.940881707366275 0.145803008744446 no 2886 0.173382741422407 921 567702 SGTC_1735 st034310 56.75 µM -0.941270407720821 0.145705194463143 no 2887 0.173283151782417 873 871153 SGTC_2731 amoxapine 43.43 µM -0.943407843827333 0.145168108929813 no 2888 0.172736166311777 951 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2151 5563267 85.4165 µM -0.943855287792018 0.145055846032803 no 2889 0.172621801606484 943 5310824 SGTC_1779 st039427 55 µM -0.946770909067793 0.144325753011352 no 2890 0.171877764276128 912 1124498 SGTC_2195 6536160 144.242 µM -0.950253066924738 0.143457045778267 no 2891 0.170991840092995 906 3834386 SGTC_936 3005-4620 401 µM -0.953544861381918 0.142639081505761 no 2892 0.170157038796544 907 777207 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.955633072729389 0.142121828482406 no 2893 0.169628823179169 911 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2958 9077254 16.72 µM -0.957211586499563 0.141731671845914 no 2894 0.16923023503917 922 16457351 SGTC_2029 5175081 200 µM -0.958989487105743 0.141293102799601 no 2895 0.168782020657193 912 1380876 SGTC_992 3909-8734 162 µM -0.959283583109155 0.141220644540751 no 2896 0.168707951717553 924 4288319 SGTC_2720 fluspirilene 36.88 µM -0.960581957960803 0.140901057009233 no 2897 0.168381201948209 933 3396 An atypical antipsychotic. SGTC_2028 5153890 36.43 µM -0.961495836072084 0.140676405567912 no 2898 0.168151459064097 931 2830968 YPR165W RHO1 SGTC_1203 3992-3522 103 µM -0.961624584121498 0.140644775997397 no 2899 0.168119108875942 940 5322312 SGTC_460 trequinsin 123 µM -0.96407121461028 0.140044628887307 no 2900 0.167505111621724 953 5537 A vasodilator. SGTC_2589 lobaric acid 100 µM -0.96528146553563 0.13974840411956 no 2901 0.16720192630181 938 73157 A novel microtubule depolymerizer. SGTC_2892 9047358 58.44 µM -0.966647275022196 0.139414616316964 no 2902 0.166860196476096 930 6466771 SGTC_2855 9016525 58.44 µM -0.969383055107365 0.138747656045176 no 2903 0.166177051797973 919 43811474 SGTC_377 3970-0964 33.1 µM -0.969863208934282 0.138630823119992 no 2904 0.166057340441509 910 16481235 SGTC_1842 st055362 61.2 µM -0.972946404850262 0.137882204811328 no 2905 0.16528996991656 907 676032 SGTC_2626 ethyl orsellinate 100 µM -0.973650775492853 0.137711567149191 no 2906 0.165114983020501 932 75653 A natural product. SGTC_2098 5376439 882.5 nM -0.974721322584494 0.137452497290788 no 2907 0.164849256587374 916 2844116 SGTC_967 1306-0166 352 µM -0.975659472325519 0.137225741014868 no 2908 0.164616621079634 913 4437607 SGTC_2719 novobiocin 32.65 µM -0.978850866300478 0.136456276176785 no 2909 0.163826836126003 937 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_713 1488-1073 324 µM -0.979121991659501 0.136391042456012 no 2910 0.16375985334771 935 3312542 SGTC_1126 isoteolin 1.0172 µM -0.979196790482122 0.136373049349924 no 2911 0.163741377080505 905 133323 SGTC_2223 6903751 107.57 µM -0.979448013156586 0.136312628784858 no 2912 0.163679331767164 915 5598863 SGTC_1744 st037937 38.9 µM -0.984243464525286 0.135162804902764 no 2913 0.162497909832975 936 1016152 SGTC_1430 4049-0248 69.1 µM -0.985430987197575 0.134879098322349 no 2914 0.162206207488977 926 22774488 SGTC_2179 6298986 200 µM -0.986621224801783 0.134595153322388 no 2915 0.161914180578299 889 738374 SGTC_2420 aureobasidin a 50 nM -0.987085903306557 0.134484410306222 no 2916 0.161800263902511 929 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_60 0986-0278 202 µM -0.987454303064565 0.13439665708111 no 2917 0.16170998723975 927 3110598 SGTC_433 pimozide 108 µM -0.987506116874057 0.134384318129476 no 2918 0.161697292857025 928 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1301 naphtanilide LB 4.81 µM -0.988630481371249 0.134116753302389 no 2919 0.161421983542045 910 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2724 maprotiline 69.64 µM -0.990384750457795 0.133700021568701 no 2920 0.160993048119503 911 4011 A tricyclic antidepressant. SGTC_1675 st018485 24.5 µM -0.991691965023216 0.133390068371447 no 2921 0.160673905904413 933 3323024 SGTC_173 1273-0061 2.693 µM -0.993784169445049 0.132895015843968 no 2922 0.160163977381125 904 2847414 YPL266W DIM1 SGTC_2337 9009472 200 µM -0.996584877196684 0.132234301248449 no 2923 0.159483024727747 904 5742383 SGTC_1068 loratadine 26.9 µM -0.996601527144718 0.132230380144508 no 2924 0.159478982202504 950 3957 A H1 histamine antagonist. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.996990619391707 0.132138770780585 no 2925 0.159384531624349 922 688803 SGTC_1410 3909-8106 77.9 µM -0.999986816507056 0.131434800605709 no 2926 0.158658443971824 921 1039210 SGTC_1045 1348-1485 165 µM -1.00111443967274 0.131170532207704 no 2927 0.15838574241727 928 6810614 SGTC_2990 9074105 71.4286 µM -1.00328355206494 0.130663214226232 no 2928 0.157862034886558 932 6502001 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.00494351380654 0.13027589520899 no 2929 0.157462024982045 926 551469 SGTC_2856 9022925 19.48 µM -1.00753855224969 0.129671987508889 no 2930 0.156838020487062 940 4944862 SGTC_73 0327-0325 16.231 µM -1.00874688287029 0.129391451937203 no 2931 0.156548020571475 880 53298 SGTC_613 3914-0030 117 µM -1.01105021714233 0.128857857296684 no 2932 0.15599619777924 897 1145395 SGTC_2218 6965428 192.983 µM -1.01186029811177 0.1286705557688 no 2933 0.155802427214485 925 675684 SGTC_2511 berberine 10.47 µM -1.0119349943149 0.128653294527596 no 2934 0.155784567951537 926 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2370 9071495 200 µM -1.01325015717757 0.128349642081645 no 2935 0.155470344175924 961 21791103 SGTC_1729 st035615 45.989 µM -1.01451455088076 0.128058181002729 no 2936 0.155168644897337 918 17385451 SGTC_158 k038-0087 26.446 µM -1.01558354468609 0.127812121365003 no 2937 0.15491387206368 890 X158 SGTC_3088 9117578 49.47 µM -1.01854787926201 0.127131514180367 no 2938 0.154208829617694 966 678341 SGTC_132 0417-1715 25.805 µM -1.0190353490002 0.127019833694202 no 2939 0.154093092487138 937 6769098 SGTC_894 0960-0238 55.9 µM -1.02007918961518 0.126780917002999 no 2940 0.153845452743105 956 6741907 YDL195W SEC31 SGTC_428 3448-4153 16.5 µM -1.0266206560217 0.12529081544069 no 2941 0.152299561840299 924 3834874 SGTC_1738 st035555 74 µM -1.02664348677273 0.125285636253575 no 2942 0.152294184557889 946 5331140 SGTC_523 1934-0222 13.7 µM -1.03491739585054 0.123418522937392 no 2943 0.150353744919615 957 1361595 SGTC_1783 st039459 87.517 µM -1.03718472356035 0.122910291624069 no 2944 0.149824888075066 955 729761 SGTC_1413 3910-0535 34.4 µM -1.03744314229509 0.122852459240158 no 2945 0.149764690465613 931 2876951 SGTC_2487 5918373 44.05 µM -1.03754170632295 0.12283040629795 no 2946 0.149741734621085 934 2876279 SGTC_3035 9091303 49.47 µM -1.03913620553979 0.12247403504738 no 2947 0.149370697328498 956 25237002 SGTC_620 0109-0052 432 µM -1.04093337803946 0.122073236703269 no 2948 0.148953234641 951 493037 SGTC_2786 7743617 45.45 µM -1.04169097589824 0.121904556482091 no 2949 0.148777487078862 930 583674 SGTC_953 1188-0045 9.7 µM -1.0423496752324 0.121758029272892 no 2950 0.148624794673743 932 6144426 SGTC_3017 9080681 49.47 µM -1.04490063889524 0.121191736960017 no 2951 0.148034447242264 959 16451914 SGTC_1509 1326-1131 80 µM -1.04559513619565 0.12103788577542 no 2952 0.147873997915674 902 768313 SGTC_3009 9080819 71.4286 µM -1.04608481882525 0.120929489580609 no 2953 0.147760936821952 951 17027216 SGTC_882 0843-0131 351 µM -1.04929956547692 0.120219569096669 no 2954 0.147020132975437 935 5425421 SGTC_1721 st082152 9.2685 µM -1.05125545740544 0.119789084077565 no 2955 0.146570639357576 939 5296051 SGTC_1232 0279-0259 161 µM -1.05396286667658 0.119194988052141 no 2956 0.145949959175921 926 1560000 SGTC_2394 5221648 200 µM -1.05472622200097 0.119027858901519 no 2957 0.145775277752534 954 788586 SGTC_39 0986-0283 58.349 µM -1.05710210193056 0.118508742478609 no 2958 0.145232496016538 902 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2202 7226349 200 µM -1.05780635499785 0.118355175033604 no 2959 0.145071867474222 939 844334 SGTC_288 1315-0019 35.1 µM -1.05788236017788 0.118338609971901 no 2960 0.145054539094207 936 6811474 SGTC_2652 actinonin 100 µM -1.05810643382371 0.1182897834479 no 2961 0.145003460772786 946 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_413 propylparaben 100 µM -1.05891178105783 0.118114412732662 no 2962 0.144819979201052 935 7175 A pharmaceutical preservative. SGTC_124 0136-0217 7.121 µM -1.06023793586155 0.117826032902815 no 2963 0.144518183306129 934 3976905 SGTC_851 0394-0702 453 µM -1.06288437721623 0.117252039275119 no 2964 0.14391719433063 950 762646 SGTC_1786 berberine 21.6 µM -1.06471456231273 0.116856245889476 no 2965 0.143502559081672 914 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_10 0279-0212 42.575 µM -1.06500797061608 0.116792881986378 no 2966 0.143436161417706 958 39851 YBR002C RER2 SGTC_1144 3486-0183 12.5 µM -1.06734031043438 0.116290060538659 no 2967 0.142909095772174 956 6744069 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.0697982195103 0.115761832351034 no 2968 0.142355071962354 941 2724 A muscle relaxant with antifungal properties. SGTC_1679 SEC14.276 6.7 µM -1.0726003440149 0.115161710374415 no 2969 0.141725235170978 937 1005053 YMR079W SEC14 SGTC_1911 st060208 74.3 µM -1.07509181028303 0.114629981601869 no 2970 0.141166812870772 960 688783 SGTC_78 0336-0123 156.75 µM -1.07638169660581 0.114355381496966 no 2971 0.140878292391741 932 6765896 SGTC_235 0330-0087 5 mM -1.07737525704497 0.114144184895293 no 2972 0.140656326719324 956 46494818 YHR062C RPP1 SGTC_119 0121-0043 24.815 µM -1.077448585838 0.114128608744735 no 2973 0.140639954162233 953 1092378 SGTC_68 0986-0284 82.829 µM -1.07811365914513 0.113987406194869 no 2974 0.140491518343664 920 423278 YIL048W NEO1 SGTC_2177 5811945 192 µM -1.0793938229716 0.113715963462963 no 2975 0.140206101706024 931 5343475 SGTC_2120 5538279 151.968 µM -1.07946511665645 0.113700860084575 no 2976 0.140190218136231 946 2058197 SGTC_809 3998-0021 90 µM -1.08110955921737 0.11335288607732 no 2977 0.139824190859802 954 715485 SGTC_2649 anisomycin 9.56 µM -1.08182294398306 0.113202166015099 no 2978 0.139665604744195 955 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_5 0352-0601 109.883 µM -1.08331372218984 0.112887664198912 no 2979 0.139334598270279 946 762456 SGTC_562 3772-2733 112 µM -1.08383516774316 0.112777804889235 no 2980 0.139218944667008 947 2876874 YIL048W NEO1 SGTC_212 3807-4682 38.772 µM -1.08797062685263 0.111909239818157 no 2981 0.138304037434686 951 3125501 YBL034C STU1 SGTC_1311 1190-0148 100 µM -1.08956625874821 0.111575393521533 no 2982 0.137952126458523 947 1961333 SGTC_99 0109-0120 622.8 µM -1.09000718237767 0.11148326700813 no 2983 0.13785499011404 931 759414 SGTC_1076 itraconazole 331 nM -1.09065365393522 0.111348291780537 no 2984 0.137712655537009 949 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1441 4106-0040 13 µM -1.09215240218122 0.111035821820065 no 2985 0.137383059842264 947 2904180 SGTC_118 0083-0097 135.343 µM -1.09329675082326 0.110797662847905 no 2986 0.137131764512549 977 5207356 SGTC_128 0906-2981 13.371 µM -1.09382118212491 0.110688641905842 no 2987 0.137016706057616 946 6740226 SGTC_1855 st056195 39.6 µM -1.09449855791344 0.110547940037383 no 2988 0.136868189751463 910 4028379 SGTC_271 rotenone 740 µM -1.09519697693047 0.110403001440515 no 2989 0.136715174914929 955 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1902 st060212 70.5 µM -1.0956352438963 0.110312120200356 no 2990 0.136619215870812 935 688944 SGTC_508 roscovitine 141 µM -1.09681017873922 0.110068744539641 no 2991 0.136362189848423 968 160355 A CDKinase inhibitor. SGTC_1830 st055982 50.3 µM -1.09943180212623 0.109527091507835 no 2992 0.135789882774891 967 455313 An antimicrobial agent. SGTC_1347 1493-0251 600 nM -1.0995081214246 0.109511351918017 no 2993 0.135773246755254 899 3986378 SGTC_1228 0124-0032 52.5 µM -1.09953227640158 0.109506370692954 no 2994 0.135767981763508 941 X1228 SGTC_3097 9117246 49.47 µM -1.10185892866324 0.109027332235379 no 2995 0.135261503288335 939 16423892 SGTC_1329 1447-1697 50.6 µM -1.10241035139317 0.108914019974594 no 2996 0.135141656662518 960 2840515 SGTC_684 1140-0066 328 µM -1.10348984262755 0.108692439675548 no 2997 0.134907250077847 952 6813534 SGTC_3221 9128209 49.47 µM -1.10426096960445 0.108534353980906 no 2998 0.134739974257762 956 16460723 SGTC_2872 9044037 25.97 µM -1.10492370610895 0.108398621207098 no 2999 0.134596324681377 950 6465195 SGTC_3022 9087993 49.47 µM -1.10529821264476 0.108321973850577 no 3000 0.134515196076776 955 17173644 SGTC_2104 5389443 200 µM -1.10927649668833 0.107510176037381 no 3001 0.133655460534081 969 2244536 SGTC_1223 0764-0573 147 µM -1.10941954670396 0.107481067524287 no 3002 0.133624616933905 942 1609797 SGTC_1391 3442-0225 151 µM -1.1103973417411 0.107282253128085 no 3003 0.133413921600323 955 5227075 SGTC_2611 pyromycin 23.93 µM -1.11279123735867 0.106796623484498 no 3004 0.13289904983295 943 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1463 k081-0032 34.1 µM -1.11325276991423 0.10670317890012 no 3005 0.132799942337569 910 977755 SGTC_1180 1193-0155 285 µM -1.11418604775392 0.106514402333758 no 3006 0.132599689859055 980 2921347 SGTC_2163 5671233 125 µM -1.11513232257329 0.106323243127023 no 3007 0.132396861122657 925 701023 SGTC_1418 3966-3099 2.4 µM -1.11772125501233 0.105801513267138 no 3008 0.131843030983192 936 740335 SGTC_315 k915-0449 187 µM -1.11859946822732 0.105624953999545 no 3009 0.13165552521971 947 20970215 YNL149C PGA2 SGTC_1606 st000094 49.2 µM -1.11931268200635 0.105481723675881 no 3010 0.131503383671013 942 1242210 SGTC_898 1000-0849 28.3 µM -1.12265772836451 0.104811832947966 no 3011 0.130791443767468 952 6751807 SGTC_830 4076-0286 57.8 µM -1.1233464586235 0.104674288686234 no 3012 0.130645189843115 948 6866659 SGTC_1873 rapamycin 2 nM -1.12501152664143 0.104342303109006 no 3013 0.130292074926521 940 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_378 3970-0959 8.33 µM -1.12623269832536 0.104099308228254 no 3014 0.130033518233092 977 6615653 SGTC_1080 nisoldipine 24.4 µM -1.1312390830294 0.10310740141121 no 3015 0.128977238090992 968 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2391 6285546 200 µM -1.13297350440486 0.102765369407563 no 3016 0.128612690062731 966 846083 SGTC_1323 1348-1351 11.2 µM -1.13531041883732 0.102305829292855 no 3017 0.128122639165806 956 6989654 SGTC_2221 6807166 181.081 µM -1.1378686201038 0.101804490016824 no 3018 0.127587673088105 943 674925 SGTC_380 3970-0968 6 µM -1.13827232159157 0.101725538939482 no 3019 0.127503393897631 953 2891601 SGTC_1975 st070967 30.8 µM -1.13984372231684 0.101418647753044 no 3020 0.127175707321491 962 261391 SGTC_2942 9052777 62.25 µM -1.14072984397019 0.101245887757298 no 3021 0.12699118162131 981 6469503 SGTC_1376 2910-0861 41.3 µM -1.1435874082307 0.100690232354131 no 3022 0.126397393064752 973 1112859 SGTC_825 1988-2224 89.6 µM -1.14509428493018 0.100398116349395 no 3023 0.126085051331825 965 1180859 SGTC_1947 st076332 61.6 µM -1.14648258101738 0.100129535601497 no 3024 0.125797765295131 953 24208416 SGTC_1456 k015-0012 13 µM -1.14954686165433 0.0995385751306391 no 3025 0.125165277572631 961 2989616 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.15000692380184 0.0994500705854323 no 3026 0.12507050978091 951 17037758 SGTC_1016 4226-1401 38 µM -1.15005648520189 0.0994405396345553 no 3027 0.12506030366324 955 2901613 SGTC_2170 morpholine 200 µM -1.15013170894826 0.0994260749381819 no 3028 0.125044814041909 969 121171 Reacts with secondary amines. SGTC_1007 4101-0031 70 µM -1.15389570546406 0.0987042625102793 no 3029 0.124271465034371 989 1146276 SGTC_3109 9122853 49.47 µM -1.1560262134156 0.0982974038372126 no 3030 0.123835217498002 987 1234709 SGTC_2515 chrysin 20.77 µM -1.16235635528238 0.0970957984942043 no 3031 0.122545371962166 937 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_644 1498-1197 63.3 µM -1.16313390492298 0.0969489485069921 no 3032 0.122387588934709 974 6741615 SGTC_1865 st057639 52.2 µM -1.16422094106607 0.0967439215272363 no 3033 0.122167242932387 964 688818 SGTC_2967 9089538 49.85 µM -1.16716061831224 0.0961910613039852 no 3034 0.121572755739542 971 728216 SGTC_991 3996-0057 64.7 µM -1.16913418983115 0.0958212002255362 no 3035 0.121174785399015 955 715343 SGTC_3202 9113761 49.47 µM -1.16948918389742 0.0957547830145391 no 3036 0.121103298254766 971 4798415 SGTC_2127 5253358 187.912 µM -1.17011638703693 0.095637519945528 no 3037 0.120977067367461 965 20612 SGTC_3182 9108849 49.47 µM -1.17171660562517 0.0953388188599673 no 3038 0.120655426918914 955 17133045 SGTC_1003 4049-0218 100 µM -1.17203263554409 0.0952799091715031 no 3039 0.120591976849104 965 295161 SGTC_1432 4049-0298 68.4 µM -1.17286483000472 0.0951249118310682 no 3040 0.120425007609354 985 741646 SGTC_185 k048-0037 25.491 µM -1.17394265339092 0.0949244418778771 no 3041 0.120208998146144 963 6827589 SGTC_2412 st077135 33.4 µM -1.17410633782933 0.0948940246052673 no 3042 0.120176217603502 991 13258915 SGTC_1224 0823-0416 294 µM -1.17415331250865 0.0948852966861927 no 3043 0.120166811302704 959 3598164 SGTC_1021 4476-0760 85.3 µM -1.17469626907423 0.0947844580066603 no 3044 0.120058126279475 977 746768 SGTC_3172 9105863 49.47 µM -1.17535844693375 0.0946615842891936 no 3045 0.119925670212885 1000 2348785 SGTC_331 k048-0133 24.5 µM -1.17783323307027 0.0942034023095098 no 3046 0.119431548464366 964 6813582 SGTC_3163 9099914 49.47 µM -1.17818114707517 0.094139120880091 no 3047 0.119362198451264 998 16268368 SGTC_1728 st035614 33.7865 µM -1.1789398608979 0.0939990513290301 no 3048 0.119211061905242 958 15945546 SGTC_2868 9035608 32.47 µM -1.18052902668447 0.0937061668470981 no 3049 0.118894936393406 967 6462614 SGTC_3070 9117005 49.47 µM -1.18322476159272 0.0932108825417551 no 3050 0.118360040984773 1009 8779016 SGTC_1946 st076057 65.1 µM -1.18348775712265 0.0931626664336214 no 3051 0.118307947885665 961 953009 SGTC_2275 7947463 200 µM -1.18544082268173 0.0928051790277625 no 3052 0.11792159962109 943 1225414 SGTC_3280 9140961 49.47 µM -1.1861262256221 0.0926799642301784 no 3053 0.117786227547083 992 4901226 SGTC_736 0958-0254 92.6 µM -1.19125757691795 0.0917464958386275 no 3054 0.116776241276973 984 6812352 SGTC_1495 4469-0029 237 µM -1.19262568612909 0.0914987967040608 no 3055 0.116508000767673 971 793680 SGTC_3198 9112019 49.47 µM -1.19325144305019 0.0913856673924226 no 3056 0.116385456509616 1004 45595555 SGTC_1266 0828-0227 32.9 µM -1.19389494409318 0.0912694383293251 no 3057 0.116259532750458 981 3913820 SGTC_602 3130-1533 38.1 µM -1.19832713554005 0.0904718723364125 no 3058 0.115394843293206 988 720941 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.20267941127294 0.0896937340642701 no 3059 0.114550202107762 990 803109 SGTC_2226 7298446 200 µM -1.20295604418484 0.0896444438962516 no 3060 0.114496665395737 977 3283010 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.20364474722005 0.0895218189858625 no 3061 0.11436345820726 985 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_111 0083-0039 52.457 µM -1.20525447694272 0.089235690098453 no 3062 0.114052538826971 947 759313 SGTC_1515 3460-0031 42.1 µM -1.20683672258512 0.0889551101755693 no 3063 0.113747515294446 961 2876596 SGTC_23 0213-0011 39.996 µM -1.20692871087425 0.0889388180982101 no 3064 0.113729799797364 985 627608 SGTC_1158 4092-0494 91.8 µM -1.20770932333545 0.0888006529553252 no 3065 0.113579545271959 977 1148199 SGTC_3192 9110362 49.47 µM -1.20826593075796 0.0887022334212553 no 3066 0.113472494352548 1008 16649480 SGTC_2718 lomofungin 53.02 µM -1.21012679973123 0.0883737836669147 no 3067 0.113115120494176 983 5351222 A RNA synthesis inhibitor. SGTC_692 k241-0027 77.8 µM -1.21061612812298 0.0882875662054281 no 3068 0.113021280067334 959 3600480 SGTC_819 1013-0258 27.7 µM -1.21300191983 0.0878680982209783 no 3069 0.112564543254331 977 5753198 SGTC_1696 st025591 34.7925 µM -1.21348426910337 0.087783472891115 no 3070 0.112472362575318 955 2787147 SGTC_1152 3909-8331 15.9 µM -1.22427126941381 0.0859068066318011 no 3071 0.110424955712664 966 16001939 SGTC_2485 5633444 17.78 µM -1.22595108712844 0.0856172829680938 no 3072 0.110108541109345 969 5724239 SGTC_1020 4335-0961 93.3 µM -1.22596682886973 0.0856145732722364 no 3073 0.110105579035493 999 669075 SGTC_206 4546-0025 72.014 µM -1.22656658763176 0.0855113819548343 no 3074 0.109992766894572 983 6620745 YIL048W NEO1 SGTC_2552 juarezic acid 87.02 µM -1.22889386624153 0.085111844589678 no 3075 0.109555800753582 982 1549512 SGTC_1075 aripiprazole 15.2 µM -1.23414766175498 0.084215041468145 no 3076 0.108573943029308 1000 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1174 0739-0097 51.1 µM -1.23662595748143 0.0837944757643758 no 3077 0.108112989279295 986 728447 SGTC_816 0325-0417 81.3 µM -1.24583592359707 0.0822453681710847 no 3078 0.106412319051653 971 68101 SGTC_1018 4259-0013 28.1 µM -1.25115435875207 0.0813606909170598 no 3079 0.105439083187694 980 6801262 SGTC_2090 5301565 104.445 µM -1.25281252536617 0.0810863418415772 no 3080 0.105136971104819 982 2056344 SGTC_155 k072-0202 43.6 µM -1.25574318513558 0.0806031628676248 no 3081 0.104604548226963 967 5857737 SGTC_1168 k815-0004 80.5 µM -1.25678853818779 0.0804313423234119 no 3082 0.104415108768724 996 642433 SGTC_1511 0906-3109 28.5 µM -1.25850151477038 0.0801503856128795 no 3083 0.104105219864612 987 2882180 SGTC_1147 3809-1045 12.3 µM -1.25873186650068 0.0801126607468956 no 3084 0.104063598613367 993 325925 SGTC_1100 amiodarone 5.07 µM -1.2593291084649 0.0800149125254674 no 3085 0.103955741759288 973 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2835 9006588 71.43 µM -1.26487447772735 0.0791116254095919 no 3086 0.102958163850519 952 2345538 SGTC_840 0245-0196 390 µM -1.26523683750894 0.0790528703789959 no 3087 0.102893220448547 994 3827528 SGTC_1118 chelidonine 707.474 nM -1.26609952238603 0.0789131228561765 no 3088 0.102738726799224 989 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_543 3844-1095 191 µM -1.26892508057441 0.0784567169110501 no 3089 0.102233893050691 986 4230703 SGTC_2726 cimetidine 79.27 µM -1.27204522221286 0.0779550557141759 no 3090 0.101678526063912 986 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3112 9123419 49.47 µM -1.27874892670661 0.0768854611624927 no 3091 0.100492742164343 1009 17015854 SGTC_296 1222-0039 74.9 µM -1.27882480913386 0.0768734180927814 no 3092 0.100479377707978 994 5984176 SGTC_1026 k007-1105 30.6 µM -1.27946090742498 0.0767725212534213 no 3093 0.100367398708532 977 7066794 SGTC_2125 5246583 200 µM -1.28437658770374 0.0759961972301273 no 3094 0.0995051103748804 1007 835267 SGTC_2513 baicalein 25.65 µM -1.29194952510248 0.0748119342641562 no 3095 0.0981873125404741 1010 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1385 3091-4834 14.1 µM -1.29252008840066 0.0747232826362747 no 3096 0.098088546858769 983 4072814 SGTC_2816 7982706 58.44 µM -1.29369829131648 0.074540472330874 no 3097 0.0978848278938474 986 2981853 SGTC_2276 7947513 42.08 µM -1.30292053314503 0.07312132144967 no 3098 0.096300946539715 1010 2105100 SGTC_344 k064-0035 6.43 µM -1.30402044883997 0.0729534519113429 no 3099 0.0961133051468557 965 5088750 SGTC_829 1635-0120 117 µM -1.30647838442578 0.0725793871889254 no 3100 0.0956949625494001 976 285054 SGTC_2897 9048598 12.99 µM -1.30661320168789 0.0725589123932759 no 3101 0.0956720553611166 1003 6467404 SGTC_2528 xanthyletin 44.79 µM -1.30790679598373 0.0723626781139316 no 3102 0.0954524620910858 1005 65188 An natural product with antifungal activity of unknown mechanism. SGTC_457 grayanotoxin iii 135 µM -1.30810969066271 0.0723319365413918 no 3103 0.095418053519499 969 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1539 benzyladenosine 56 µM -1.30934466304278 0.0721450355836151 no 3104 0.0952088135056118 970 92208 A nucleotide analog. SGTC_2924 9010168 62.78 µM -1.31163594350428 0.0717992535837946 no 3105 0.0948214996735324 1011 2993929 SGTC_2760 etidronate 98.04 µM -1.314761438248 0.071329629868457 no 3106 0.094295045531326 989 3305 A chelator and antioxidant. SGTC_1758 st042942 75.2445 µM -1.31560283452908 0.0712036088876695 no 3107 0.0941536908483986 990 669317 SGTC_1402 3909-7673 35.9 µM -1.31950883732929 0.0706208210631742 no 3108 0.0934995288187137 1003 5328014 SGTC_565 1418-0001 44.5 µM -1.32045010527833 0.070480930624405 no 3109 0.0933423920695277 998 2862145 SGTC_353 1988-1175 58.3 µM -1.33353832404691 0.0685577771916554 no 3110 0.091177603778042 977 2788357 SGTC_950 1165-0508 94.1 µM -1.33391483861471 0.0685030580002875 no 3111 0.0911158839702257 1000 6148369 SGTC_3206 9114350 49.47 µM -1.33394640497691 0.0684984719644057 no 3112 0.0911107108911278 989 17087243 SGTC_35 0133-0054 64.071 µM -1.33449307904408 0.068419087423586 no 3113 0.0910211567755315 986 99677 SGTC_2787 5284540 71.43 µM -1.33473091381004 0.0683845727333144 no 3114 0.0909822159558328 1006 736958 SGTC_897 1000-0139 31.4 µM -1.33521829653268 0.0683138855038427 no 3115 0.0909024551228794 999 6151020 SGTC_1389 3405-0187 19 µM -1.3369731468112 0.0680598388842389 no 3116 0.0906157011818536 983 799890 SGTC_3079 9117512 49.47 µM -1.33963083145343 0.0676764800709066 no 3117 0.090182697522114 1049 7185044 SGTC_1641 st009299 47.1 µM -1.34092934525506 0.0674897830798232 no 3118 0.0899716967431846 988 4046054 SGTC_1929 genistein trimethyl ether 50.5 µM -1.34099800583749 0.0674799223273098 no 3119 0.0899605500269303 977 136420 SGTC_1802 st050112 57.9 µM -1.34353998681891 0.0671156364973442 no 3120 0.0895485935837323 1003 4662563 SGTC_1171 0368-0077 21.4 µM -1.34367321655082 0.0670965856546325 no 3121 0.0895270409707119 999 3239779 SGTC_3308 9128332 17.569 µM -1.34372519338028 0.0670891544957152 no 3122 0.0895186337098376 992 17332805 YDL196W YDL196W SGTC_2910 7948405 25.97 µM -1.34466644700816 0.0669546929911264 no 3123 0.0893664873534594 959 2971328 SGTC_1552 6-methylflavone 10.6 µM -1.34467474763762 0.0669535081439655 no 3124 0.0893651464772214 1003 689013 SGTC_1427 4048-4900 550 nM -1.35520293146136 0.0654637099496262 no 3125 0.0876764554912408 999 24132586 SGTC_624 k048-0052 28 µM -1.35683443215928 0.065235161994451 no 3126 0.0874169121333907 1012 6835531 SGTC_1239 0337-0584 35.4 µM -1.35765842600645 0.0651199687632276 no 3127 0.0872860472169656 1007 914301 YML130C ERO1 SGTC_31 0508-1974 57.237 µM -1.35855724794187 0.064994494737801 no 3128 0.0871434651144152 965 6810525 SGTC_773 4358-1457 44.6 µM -1.35858299159463 0.0649909037336471 no 3129 0.0871393839057604 1026 1186886 SGTC_2705 st078069 42.8 µM -1.35972329807321 0.0648319958449879 no 3130 0.0869587512896559 1006 1530061 SGTC_285 1486-1325 46 µM -1.36028822471236 0.0647533820849111 no 3131 0.0868693665899695 994 22310230 SGTC_2149 5554786 194.827 µM -1.36662630855324 0.0638764565317446 no 3132 0.0858712333103599 1020 745063 YPR165W RHO1 SGTC_2529 gangaleoidin 93.61 µM -1.36868260775276 0.0635939438637044 no 3133 0.0855492546076346 1019 4565183 SGTC_2181 6316240 54.2555 µM -1.36994195724986 0.0634214038867758 no 3134 0.0853525104769335 1017 12779990 SGTC_1922 5578187 25 µM -1.37012688026657 0.0633960988074059 no 3135 0.0853236491097171 956 1350412 SGTC_2759 disulfiram 3.38 µM -1.3701668948041 0.0633906242062792 no 3136 0.085317404909632 975 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3276 9139060 49.47 µM -1.37022818217009 0.0633822398701259 no 3137 0.0853078417847893 1010 4870619 SGTC_431 k089-0097 107 µM -1.37129358335647 0.0632366269785274 no 3138 0.0851417275824774 952 5499420 SGTC_3158 9100007 49.47 µM -1.37285454608022 0.0630237541358406 no 3139 0.0848987847939729 1009 19297233 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.37349369714823 0.0629367525508366 no 3140 0.0847994596513789 1000 5357218 A potent inhibitor of glutathione S-transferases. SGTC_210 3551-0445 56.827 µM -1.37445415905051 0.0628061899380874 no 3141 0.0846503661492307 1011 2865180 YOR207C RET1 SGTC_254 nsc-64875 3.808 µM -1.37982979895662 0.0620793323964855 no 3142 0.0838195276513106 1012 56993 SGTC_489 paxilline 115 µM -1.38079008832905 0.061950182273957 no 3143 0.0836717559683399 1011 105008 A toxic potassium channel blocker. SGTC_1676 st018489 23.4 µM -1.38293656400469 0.0616622591691783 no 3144 0.0833421588448237 990 3696235 SGTC_341 1486-1430 230 µM -1.38339855900471 0.0616004251249796 no 3145 0.0832713460790581 1021 2054753 YPL210C SRP72 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.38628143606373 0.0612156700394599 no 3146 0.0828304915616429 985 688667 SGTC_1108 betulinic acid 729.144 nM -1.38918216944028 0.0608304297526665 no 3147 0.0823886811373932 1004 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1661 st013063 9.66 µM -1.39147109297844 0.0605277829032031 no 3148 0.082041309740682 1008 721395 SGTC_2849 9019321 12.99 µM -1.39451181407192 0.0601275551322834 no 3149 0.0815815522288168 995 16489627 SGTC_424 splitomicin 100 mM -1.39574686084082 0.059965587906102 no 3150 0.0813953687354819 1017 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3331 9141060 1.957 µM -1.39618543568656 0.05990815434885 no 3151 0.0813293306773671 1000 4906567 YPR165W RHO1 SGTC_214 4373-3496 70 µM -1.39955647902255 0.0594681366519258 no 3152 0.0808230871248839 1015 3779166 SGTC_289 k017-0060 526 µM -1.40160502108281 0.0592019832579122 no 3153 0.0805166133939164 1017 5512909 SGTC_1486 3970-0793 4.53 µM -1.40300275888347 0.0590209212930549 no 3154 0.0803080081256579 1025 2844330 SGTC_2963 9082507 9 µM -1.40377058030468 0.0589216432741959 no 3155 0.0801935886163796 1020 16459611 SGTC_2117 5521686 200 µM -1.40535875635534 0.0587167106145354 no 3156 0.0799573122617659 1020 803312 SGTC_1218 1348-1416 30.7 µM -1.40565321438344 0.0586787763371254 no 3157 0.0799135630145299 996 6787668 SGTC_1227 3909-8010 46.6 µM -1.40601495295111 0.0586322008154345 no 3158 0.0798598423093311 1014 15982272 SGTC_1959 st077091 55.8 µM -1.40665748009045 0.0585495440205529 no 3159 0.0797644898844822 996 821356 YKL052C ASK1 SGTC_610 4215-0184 155 µM -1.408857739906 0.0582671883031846 no 3160 0.0794386188670802 959 5605015 SGTC_1479 0549-0158 134 µM -1.41025690894359 0.0580881923452066 no 3161 0.0792319186707179 1018 5440202 SGTC_2379 9035213 200 µM -1.41073786024804 0.0580267640415515 no 3162 0.0791609615282764 997 646551 SGTC_1927 st060202 13.8 µM -1.41564158246859 0.0574033583984236 no 3163 0.0784402350476935 986 688887 SGTC_1631 benzylvanillin 81.9 µM -1.42268726023781 0.0565168867758838 no 3164 0.0774134176810725 981 75506 SGTC_2400 5203494 178.7 µM -1.42433417516819 0.0563112391460463 no 3165 0.0771748795255716 994 6777674 SGTC_2779 methotrexate 400 µM -1.43314336471971 0.0552212483621002 no 3166 0.0759084354394141 985 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3267 9137951 49.47 µM -1.43356965709035 0.0551689274950006 no 3167 0.0758475538111882 1051 16643986 SGTC_1358 1509-0022 2.48 µM -1.44264323584012 0.0540645449690087 no 3168 0.0745604986196386 1008 3258434 SGTC_3138 9097216 49.47 µM -1.44319666957951 0.0539977546089842 no 3169 0.0744825387253562 1009 25237486 SGTC_3098 9119039 49.47 µM -1.44500096784759 0.0537804589587924 no 3170 0.0742288068910256 1003 17161528 SGTC_351 caspofungin 25 nM -1.44500689495662 0.053779746286722 no 3171 0.0742279744726714 1010 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.44622193794456 0.0536338080847762 no 3172 0.0740574812153444 991 2346 DNA damaging agent; causes G2/M arrest. SGTC_2376 9072922 81.32 µM -1.45286015136975 0.0528420265111741 no 3173 0.0731312934241577 1015 17087968 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.45511670935957 0.0525749942613631 no 3174 0.0728184770221757 968 688669 SGTC_912 3474-0017 2.18 µM -1.45601626877594 0.0524688429478593 no 3175 0.0726940611566483 1023 3360550 SGTC_261 5-fluorouridine 15.376 µM -1.46866114391083 0.0509946351382136 no 3176 0.0709623607660167 1019 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.47113071499043 0.0507106045093284 no 3177 0.0706278849752447 1024 2333 A French combination drug. SGTC_294 k038-0071 157 µM -1.47270308873314 0.050530419871411 no 3178 0.0704155566886719 1025 24152826 SGTC_3239 9133757 49.47 µM -1.47947742633598 0.0497599463209097 no 3179 0.0695063800776236 1051 17036923 SGTC_2131 toluylene red 5.2905 µM -1.48037170230182 0.0496589406201064 no 3180 0.0693870387648184 986 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2352 9027995 87.8 µM -1.48235087398377 0.0494359809897518 no 3181 0.0691234791136651 1007 2997347 SGTC_2715 st079500 56.4 µM -1.48468520200833 0.0491740397699632 no 3182 0.0688136167534186 1019 28246688 SGTC_400 oxethazaine 37.5 µM -1.48763128614793 0.0488450353190692 no 3183 0.0684240789573841 1015 4621 A local anesthetic. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.4888132826507 0.0487135311154252 no 3184 0.0682682718123246 1016 7104 SGTC_2656 pseudo-anisatin 100 µM -1.49153813373527 0.0484114531898129 no 3185 0.0679101335635878 1054 6708809 A neurotoxin. SGTC_2904 7225135 42.03 µM -1.50071234000024 0.0474053969424763 no 3186 0.0667149899856437 1051 4446116 SGTC_981 1488-1094 54.9 µM -1.5040413733372 0.0470444996336199 no 3187 0.0662853570572552 1013 3449522 SGTC_807 1315-0151 48 µM -1.51741232511893 0.0456171062021035 no 3188 0.0645813070264585 1024 4011080 SGTC_2102 5377816 72.7585 µM -1.52139399319986 0.0451988438698095 no 3189 0.0640804976826081 1015 1379702 SGTC_3159 9100096 49.47 µM -1.52380511626202 0.0449470662533629 no 3190 0.0637787005627929 1035 25236875 SGTC_3311 9131146 2.8755 µM -1.53281666321035 0.0440160291939516 no 3191 0.0626605168903494 1036 4900406 YPR165W RHO1 SGTC_77 0828-0286 12.516 µM -1.53327020255674 0.0439695854717178 no 3192 0.0626046466188905 1011 745345 SGTC_2571 chrysanthemic acid 100 µM -1.53918527803828 0.0433674763509635 no 3193 0.0618795353250757 1038 2743 An insecticide. SGTC_2072 5231554 129 µM -1.54081105785079 0.0432031559536743 no 3194 0.061681388696796 1023 789545 SGTC_1951 sophoraflavanone G 9.2 µM -1.54838566831625 0.0424441943392361 no 3195 0.0607647348345942 1008 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1896 st058441 89 µM -1.55012472802441 0.0422714748647649 no 3196 0.0605557909633533 1017 688759 SGTC_2251 lansoprazole 556 µM -1.5579065645395 0.0415055537350599 no 3197 0.0596276994255251 1041 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_960 1222-0186 7.7 µM -1.5598389232008 0.0413171160242782 no 3198 0.05939897538503 1029 3126296 SGTC_3350 9150499 3.57 µM -1.56145454126544 0.0411600986851776 no 3199 0.0592082708341268 1037 4910996 YPR165W RHO1 SGTC_3000 9075062 71.4286 µM -1.56639092905775 0.0406833405612759 no 3200 0.0586285626184029 993 17057871 SGTC_2446 5162541 200 µM -1.56837041486009 0.0404934243517604 no 3201 0.058397355710835 1044 1549321 SGTC_217 ketoconazole 989 nM -1.57717103641878 0.0396577688885474 no 3202 0.0573780877387442 971 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3089 9117425 49.47 µM -1.58129974895755 0.0392705917877374 no 3203 0.0569047584965883 1042 9401657 SGTC_2961 9083290 32.55 µM -1.58285949794683 0.0391251265661386 no 3204 0.0567267459855299 1034 17741490 SGTC_159 3970-0959 50 µM -1.58490586001185 0.0389349444034063 no 3205 0.05649386245657 1011 6615653 SGTC_2124 5246320 200 µM -1.58727854575585 0.0387153779471937 no 3206 0.0562247860436578 1025 579342 SGTC_3227 9130768 49.47 µM -1.59371024923096 0.0381252627476131 no 3207 0.055500473783896 1067 17720899 SGTC_1594 piperine 70.1 µM -1.59964666989529 0.0375871206802225 no 3208 0.0548384944490396 1037 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.60103714042692 0.037461973846278 no 3209 0.0546843466360547 1043 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2575 plumbagin 510 nM -1.60140808717043 0.0374286450050662 no 3210 0.0546432813538173 1024 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_51 1013-0126 23.419 µM -1.60753877163613 0.0368813141166244 no 3211 0.0539681156684873 1032 1627850 SGTC_2455 5377712 9.75 µM -1.61305067387181 0.0363948296429072 no 3212 0.0533667495012891 1012 2243908 SGTC_1205 4161-2785 76 µM -1.61578048994634 0.0361558458219751 no 3213 0.0530708906035195 1028 3498106 SGTC_407 eburnamonine 100 µM -1.62502646523439 0.0353559293990588 no 3214 0.0520784599156105 1028 3195 SGTC_3130 9127414 49.47 µM -1.62606286199263 0.0352671771282128 no 3215 0.0519681416916492 1038 1494646 SGTC_2723 salbutamol 83.58 µM -1.629120010214 0.035006441057414 no 3216 0.0516438079754005 1028 9884233 β2-adrenoceptor agonist SGTC_3258 9138477 49.47 µM -1.6361864961579 0.0344098107644883 no 3217 0.0509002808807147 1061 4970355 SGTC_552 k242-0005 476 µM -1.63765317061143 0.0342870310325145 no 3218 0.0507470323193418 1047 4088318 SGTC_1310 1188-0297 994 nM -1.64169193075312 0.0339507941659696 no 3219 0.0503269323917144 1004 1588352 SGTC_3210 9128157 49.47 µM -1.64183090096636 0.0339392729844151 no 3220 0.050312526593032 1011 17590849 SGTC_2371 9071574 200 µM -1.64349718777565 0.0338013814695435 no 3221 0.0501400533616078 1056 45596039 SGTC_2047 4141938 200 µM -1.64656787430569 0.0335484779992775 no 3222 0.0498234491138957 1049 3807862 SGTC_1392 3455-1037 33.9 µM -1.64900563858289 0.0333488132634406 no 3223 0.049573239777628 1016 981132 SGTC_340 k038-0059 454 µM -1.65090665399698 0.0331937908364199 no 3224 0.0493788184619296 1045 23733424 SGTC_977 1348-1378 135 µM -1.65130072809532 0.0331617296036394 no 3225 0.0493385918511166 1025 X977 SGTC_339 3091-4833 71.4 µM -1.66991474491552 0.0316761390641709 no 3226 0.0474681163027226 1016 3240077 SGTC_861 0443-0273 110 µM -1.67272751850343 0.0314565081625225 no 3227 0.0471904746639949 1035 6149169 SGTC_1780 st038448 24.544 µM -1.67931064374818 0.0309473936312544 no 3228 0.046545758846907 1033 728868 YDL195W SEC31 SGTC_1489 4065-0444 182 µM -1.68403127761906 0.0305865311102768 no 3229 0.0460878120935212 1021 2877968 SGTC_2496 diffractaic acid 79.83 µM -1.68600139750271 0.0304369621306776 no 3230 0.0458977650935474 1035 94870 An apoptosis inducer which activates caspases. SGTC_224 benfluorex 43.875 µM -1.689087493602 0.0302038880450923 no 3231 0.0456013320870869 1060 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1272 0839-0021 27 µM -1.69116589858853 0.0300477539256003 no 3232 0.0454025610248076 1046 5027250 SGTC_2069 5228469 200 µM -1.69126721377987 0.0300401600553114 no 3233 0.0453928894503831 1044 2835210 SGTC_2320 7373003 200 µM -1.70743389008237 0.02884864583733 no 3234 0.0438707178789964 1021 5415828 SGTC_2806 7952793 58.44 µM -1.71428493973381 0.0283556988658297 no 3235 0.0432382038377119 1027 2972490 SGTC_2815 7968870 71.43 µM -1.71526930693335 0.0282854509411485 no 3236 0.0431479315744183 1050 2977326 YHR190W ERG9 SGTC_1607 st000305 50.6 µM -1.71558760773522 0.0282627668845858 no 3237 0.0431187741104916 1046 5457690 SGTC_462 ag-879 158 µM -1.7210811508672 0.0278736434049639 no 3238 0.0426180495811572 1045 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_635 k038-0028 24.7 µM -1.72458811523315 0.02762757673457 no 3239 0.0423008633827195 1055 4035102 SGTC_157 1348-1695 65.819 µM -1.72476349135131 0.0276153191300021 no 3240 0.0422850518266377 1017 5380510 SGTC_1852 st056254 31.4 µM -1.72856624549208 0.0273506451292244 no 3241 0.0419433775984955 1052 442583 SGTC_1381 2324-0066 62.1 µM -1.73002122422335 0.0272499388800595 no 3242 0.0418132416328503 1050 10885928 SGTC_860 0443-0016 25.1 µM -1.7303756855631 0.027225451776193 no 3243 0.0417815875413076 1047 5337942 SGTC_2290 7904846 200 µM -1.73085430489046 0.0271924166482806 no 3244 0.0417388766944491 1027 2962154 SGTC_313 3474-0040 5.03 µM -1.73187524880232 0.0271220610881881 no 3245 0.0416478882567277 1060 1043375 YIL048W NEO1 SGTC_3156 9099931 49.47 µM -1.73868740597619 0.0266564978838554 no 3246 0.0410448812432864 1060 18111053 SGTC_1825 st052143 62.6 µM -1.7411817625747 0.0264877041770742 no 3247 0.0408258614924579 1058 674173 SGTC_1816 st051957 91.6 µM -1.74173888523017 0.0264501258200375 no 3248 0.0407770724920384 1068 674121 SGTC_3352 9151559 45.5865 µM -1.74174268031386 0.0264498699915406 no 3249 0.0407767403068099 1050 17159339 SGTC_2962 9082311 13.18 µM -1.74566313330716 0.0261866924197064 no 3250 0.0404347524104852 1048 16459453 SGTC_2073 5212005 126 µM -1.74691027012483 0.026103433339649 no 3251 0.0403264520335535 1033 691789 SGTC_1752 st044819 83.042 µM -1.74823963142752 0.026014928813617 no 3252 0.0402112708501874 1037 441209 YML126C ERG13 SGTC_3185 9108267 49.47 µM -1.7534822161952 0.0256683378590709 no 3253 0.0397596347457463 1050 4910486 SGTC_729 4092-0585 94.1 µM -1.75840836151067 0.0253461976954465 no 3254 0.03933902571989 1032 2169061 SGTC_3356 9151811 4.48 µM -1.76138048344262 0.0251534820303681 no 3255 0.0390870130202924 1053 1859254 YPR165W RHO1 SGTC_2395 5646831 180.19 µM -1.76167401029202 0.0251345162318074 no 3256 0.0390621957084262 1062 6808628 SGTC_3256 9138902 49.47 µM -1.77938558642224 0.0240120883859974 no 3257 0.0375882839443652 1074 17228773 SGTC_1772 st048439 82.2 µM -1.78065331370202 0.0239333905575408 no 3258 0.0374845522168225 1037 2927068 YDL195W SEC31 SGTC_2475 5812728 15.03 µM -1.7819421454955 0.0238536049294731 no 3259 0.0373793333825721 1048 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2488 5268135 45.7 µM -1.78941375404529 0.0233954646951429 no 3260 0.0367741029431673 1037 1270356 YLR208W SEC13 SGTC_1904 st060225 78 µM -1.79427655487012 0.0231012854812221 no 3261 0.0363845191514658 1035 66595 SGTC_2271 7849410 118.62 µM -1.8018288531838 0.0226505813206152 no 3262 0.0357861683426927 1057 972430 SGTC_3146 9095609 49.47 µM -1.80285780736346 0.0225897532061934 no 3263 0.0357052743931657 1051 17173999 SGTC_1643 st009866 20.2 µM -1.80752198855263 0.0223157476514098 no 3264 0.0353404647083776 1033 3156273 YOR207C RET1 SGTC_1870 st057514 26.5 µM -1.81274567110363 0.0220122069616046 no 3265 0.034935528430601 1053 5393161 SGTC_1375 2910-0797 186 µM -1.82047466432535 0.0215694849268965 no 3266 0.0343433755586662 1053 742508 SGTC_2464 5717415 7.67 µM -1.82478523553585 0.0213258576821993 no 3267 0.0340167223765023 1056 5285744 SGTC_1452 4194-0072 190 µM -1.83256885979715 0.0208918316352519 no 3268 0.0334333563257052 1051 1343545 SGTC_3335 9143315 29.6265 µM -1.84265783161269 0.0203404036977632 no 3269 0.0326894922309436 1044 4899691 SGTC_1827 berberine 7.24 µM -1.84481432240135 0.0202241515197962 no 3270 0.0325322766303425 1012 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_176 1486-1328 72.834 µM -1.85156828755656 0.0198636971880512 no 3271 0.0320439201897257 1044 22310231 SGTC_867 0518-0118 155 µM -1.85232441700913 0.0198236845338332 no 3272 0.0319896257689295 1037 6848158 SGTC_145 3737-0113 38.366 µM -1.86073842566171 0.0193830311977484 no 3273 0.031390562319922 1046 6849351 SGTC_2937 9044753 11.33 µM -1.87214596885738 0.0187989143007314 no 3274 0.0305932058888427 1034 6465530 YGL099W LSG1 SGTC_850 0388-0143 75.9 µM -1.87760452740005 0.0185247526169414 no 3275 0.0302176429682372 1069 67273 SGTC_1844 rapamycin 4 nM -1.88284500936696 0.0182647546712386 no 3276 0.0298606876805032 1005 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2979 9012552 45.46 µM -1.89591383551312 0.0176298771999456 no 3277 0.02898571956805 1064 17100905 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.90250380840987 0.017316946941272 no 3278 0.0285526607210407 1068 2374 Ca(2+)-ATPase inhibitor. SGTC_1214 0358-0031 63.7 µM -1.90921117074985 0.0170033266278299 no 3279 0.0281174279148441 1065 4301366 SGTC_2698 st077697 67.5 µM -1.91046184641789 0.016945388297769 no 3280 0.0280368871772674 1066 3154499 SGTC_1186 1319-0216 26 µM -1.91754241335641 0.0166205498677187 no 3281 0.0275845290362892 1057 4565136 SGTC_486 niguldipine 82 µM -1.91799117848317 0.0166001424589137 no 3282 0.0275560648579774 1068 1236 A calcium channel blocker. SGTC_404 fumagillin 50 µM -1.9262356000766 0.0162290290214259 no 3283 0.0270374812639851 1056 12015870 A methionine aminopeptidase binder. SGTC_777 1315-0167 517 µM -1.93019286640354 0.0160534363154577 no 3284 0.0267914725593404 1039 4221767 SGTC_1557 sumaresinolic acid 42.3 µM -1.93062394138359 0.0160344072725646 no 3285 0.0267647874627987 1056 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_605 1315-0399 119 µM -1.93659714849918 0.0157727140917329 no 3286 0.0263973034055303 1071 24020461 SGTC_1116 jasmonic acid  1.58368 µM -1.94165111792598 0.0155541631130337 no 3287 0.0260896750424595 1055 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1817 st052116 64.4 µM -1.94268063308077 0.0155099634016832 no 3288 0.0260273788260521 1069 4361398 SGTC_643 k048-0106 28.4 µM -1.96281750158235 0.0146668655460078 no 3289 0.024833691720479 1065 6763920 SGTC_501 nsc-95397 161 µM -1.96928129598618 0.0144047334516342 no 3290 0.0244603989089887 1055 262093 SGTC_3343 9148379 18.9835 µM -1.97899723367793 0.0140183060195117 no 3291 0.0239081588611251 1034 1955036 SGTC_1702 st027038 51 µM -1.98736166266649 0.0136928218102691 no 3292 0.023441166451443 1072 5521182 SGTC_769 0302-0231 76 µM -1.98802049343802 0.0136674640649871 no 3293 0.0234047117543214 1068 571869 YER009W NTF2 SGTC_2853 9015042 58.44 µM -1.98992102331045 0.0135945414550166 no 3294 0.0232998180414255 1053 6457456 SGTC_1731 st035964 63 µM -1.99839577265039 0.0132734412431024 no 3295 0.0228368847929766 1055 6739575 SGTC_432 NS 1619 61.3 µM -2.00090567594006 0.0131796098270795 no 3296 0.0227012778948076 1048 4552 A K+/calcium channel activator. SGTC_933 2914-0560 114 µM -2.00349927307723 0.0130832522399049 no 3297 0.0225618627712487 1062 463887 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.02368326764834 0.0123539659712982 no 3298 0.0215013756451028 1060 115019 SGTC_2974 9094440 9.66 µM -2.02687984671451 0.0122417584124322 no 3299 0.0213373510200045 1054 25236134 SGTC_728 3030-5151 22.5 µM -2.02893536570506 0.0121700722353235 no 3300 0.0212324370133615 1079 3125388 SGTC_52 0329-0193 875 nM -2.03192438476811 0.0120664795841967 no 3301 0.0210806557496165 1056 3739292 SGTC_944 3370-0224 231 µM -2.07376468543678 0.0106946863041603 no 3302 0.0190505852045052 1062 4580514 SGTC_3303 9125618 40.5795 µM -2.09197520133224 0.0101413775833704 no 3303 0.0182203670561205 1058 22695467 SGTC_349 k015-0014 24 µM -2.09697560922857 0.00999388489963837 no 3304 0.0179978672676298 1062 2196908 SGTC_1821 st053465 65.6 µM -2.10388362134103 0.00979320698100419 no 3305 0.017694300020229 1081 675086 SGTC_2564 betulinic acid 100 µM -2.10459567778745 0.00977272320581099 no 3306 0.0176632590958613 1076 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1571 st070080 73.4 µM -2.11038106349794 0.00960767745457396 no 3307 0.0174127731131299 1069 4315245 SGTC_103 0844-0104 51.839 µM -2.11944950952942 0.00935387388927269 no 3308 0.0170262482364812 1043 5375804 SGTC_2490 carminic acid 95.39 µM -2.11969507502475 0.0093470834592352 no 3309 0.0170158843032579 1061 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3099 9120367 49.47 µM -2.16560086223881 0.00815104627708931 no 3310 0.0151708502243966 1078 24824940 SGTC_678 1218-2179 85.9 µM -2.17535599022121 0.00791494693011096 no 3311 0.0148017248869058 1085 6820081 YOR116C RPO31 SGTC_1554 st069299 38.7 µM -2.1782937598057 0.00784503370963879 no 3312 0.0146920867289292 1065 24207999 SGTC_1623 st003709 20.3 µM -2.18504903097987 0.00768632863225239 no 3313 0.0144426258835516 1076 16192618 SGTC_2546 rhodinyl acetate 100 µM -2.18544460781603 0.00767712335863649 no 3314 0.0144281315946222 1059 6708682 SGTC_1727 st034309 9.9045 µM -2.18567656974548 0.00767173000189085 no 3315 0.014419638128362 1074 870305 SGTC_2965 9082772 38.63 µM -2.20294818751568 0.00727940086248364 no 3316 0.0137992003526608 935 16459634 SGTC_1905 st060207 84.5 µM -2.20624856051036 0.00720647853507331 no 3317 0.0136833004404154 1066 1948547 SGTC_723 4182-0001 115 µM -2.27501598815617 0.00582680659033238 no 3318 0.0114524853727789 1068 744821 YLR208W SEC13 SGTC_3154 9100113 49.47 µM -2.27625371981493 0.00580428462294488 no 3319 0.011415414171768 1070 25237525 SGTC_2610 ononetin 44.17 µM -2.33077799098207 0.00488571787901608 no 3320 0.00988253461693524 1075 259632 SGTC_1892 st058411 7.36 µM -2.34849847424519 0.00461640695591077 no 3321 0.0094246382122808 1085 3934738 SGTC_392 N-ethylmaleimide 8.33 µM -2.35062018914316 0.00458506646249261 no 3322 0.00937107686136809 1073 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1756 st041558 35.5 µM -2.3697389953314 0.00431111135895016 no 3323 0.00890032318975867 1074 3955792 SGTC_112 phenothiazine 287.218 µM -2.38003541543397 0.00416971784869592 no 3324 0.00865548711713673 1084 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_151 3013-0144 2.285 µM -2.39658728883928 0.00395110262840933 no 3325 0.00827427567915561 1068 906558 YHR107C CDC12 SGTC_2329 6138490 200 µM -2.40235196184025 0.00387740900114938 no 3326 0.00814501326940046 1077 720019 SGTC_2549 cedrol 20.94 µM -2.4682824016287 0.00311805433834474 no 3327 0.00678815830058289 1080 6708665 A sedative which affects the nervous system. SGTC_496 calpeptin 138 µM -2.48876540147094 0.00291103752249889 no 3328 0.00640937603187075 1077 73364 A calpain inhibitor. SGTC_1262 0737-0114 49.6 µM -2.51253801240778 0.00268636767051481 no 3329 0.00599330954293177 1081 765919 SGTC_1647 st011722 22.4 µM -2.54643248535424 0.00239307929460711 no 3330 0.00544151306903538 1080 2854783 SGTC_2247 cerulenin 830 nM -2.54955324946309 0.00236758853277066 no 3331 0.00539305189088689 1073 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_101 0490-5701 117.494 µM -2.57859034168423 0.00214193156657571 no 3332 0.00496021778122557 1079 4661669 SGTC_2405 ticlatone 3.52 µM -2.57934612901589 0.0021363276953957 no 3333 0.00494937734701984 1072 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2254 7938975 95.19 µM -2.60108689293353 0.00198071323013628 no 3334 0.00464644563357746 1086 2969277 SGTC_2283 7944793 200 µM -2.60209283443223 0.00197376864555796 no 3335 0.00463283833924164 1068 2970533 SGTC_659 k018-0002 107 µM -2.70380243574527 0.00137570069987643 no 3336 0.00342755167465853 1087 6797879 YHR007C ERG11 SGTC_2968 9090663 33.37 µM -2.70922591249528 0.00134903312194651 no 3337 0.00337202008248823 1069 25236811 SGTC_2242 6630449 61.2675 µM -2.71756188923561 0.00130896452184502 no 3338 0.00328824273693629 1083 691249 YDR170C SEC7 SGTC_1649 st011737 51.3 µM -2.72524303289589 0.00127300974798227 no 3339 0.00321270855713174 1070 1761035 SGTC_40 0327-0103 19.753 µM -2.85053782282201 0.000800646284557743 yes 3340 0.00218226795572655 1073 409036 SGTC_947 3447-0010 211 µM -2.8590778085533 0.000775235741251725 yes 3341 0.00212437278479047 1091 748350 SGTC_16 erodoxin 22.806 µM -2.87016513997363 0.00074335349531947 yes 3342 0.00205128737878378 1091 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1853 st056710 91.2 µM -2.87407942606781 0.000732389404370091 yes 3343 0.00202603523307499 1090 269167 SGTC_2162 5663267 200 µM -2.89923395227786 0.000665412585932772 yes 3344 0.00187037829261423 1084 6456493 SGTC_2365 9042475 200 µM -2.98845369938129 0.000470813520521739 yes 3345 0.00140196490251988 1081 6464479 SGTC_2795 7780010 54.55 µM -3.02685706037321 0.000404549075771669 yes 3346 0.00123555390285731 1079 953673 SGTC_277 nystatin 15.5 µM -3.05646480078885 0.000359488057075321 yes 3347 0.00111981887534656 1094 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3320 9137005 35.139 µM -3.18335079990837 0.000214278976646721 yes 3348 0.000727905596741271 1092 4908713 SGTC_1759 st043059 70 µM -3.22623741215408 0.000179153928736108 yes 3349 0.000627146335240343 1091 669426 SGTC_2679 rapamycin 1 nM -3.33433395761962 0.00011302978238037 yes 3350 0.000427519662450174 1063 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1655 st012546 55.1 µM -3.47814685784998 5.99850522864215e-05 yes 3351 0.000252446612758911 1094 720985 YLR208W SEC13 SGTC_1129 3453-1384 223 µM -4.08262399709066 3.22229331039412e-06 yes 3352 2.22650193422857e-05 1094 1084452 SGTC_1914 st062367 72.6 µM -4.25645851388356 1.28490556826496e-06 yes 3353 1.03845276864684e-05 1092 978205 SGTC_516 3992-2719 87.3 µM -5.71297245618882 1.44082480002027e-10 yes 3354 5.55098270508747e-09 1095 5350887 YDR037W KRS1 SGTC_2797 7859098 81.82 µM -5.93357585964533 2.92089797127216e-11 yes 3355 1.48203475408521e-09 1094 972681 SGTC_2796 7949634 45.45 µM -7.61716611664052 2.23102880298751e-17 yes 3356 1.29652770006235e-14 1095 2971588