SGTCid condition conc unit UBX6|YJL048C.score UBX6|YJL048C.strain.pval UBX6|YJL048C.strain.significant UBX6|YJL048C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1575 cyproterone acetate 48 µM 6.38967027139747 6.50262565106483e-12 yes 1 8.31219159066009e-11 3 9880 An androgen receptor antagonist and liver toxin.
SGTC_1531 st059297 52.4 µM 6.1109717672316 4.79235012589462e-11 yes 2 4.95131426946138e-10 1 7566702
SGTC_766 1391-0721 126 µM 5.04228888547739 4.61344528836564e-08 yes 3 2.29998065104528e-07 3 1020919 YIL115C NUP159
SGTC_2612 dictamnine 15.46 µM 4.81415412809042 1.70124861704562e-07 yes 4 7.39123435123853e-07 25 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2519 cryptotanshinone 88.04 µM 4.75861791900354 2.31746856007275e-07 yes 5 9.74615037691883e-07 6 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2908 7930301 100 µM 4.31568201435337 2.41953128107192e-06 yes 6 7.95554424608793e-06 17 2223178
SGTC_1271 0832-2808 169 µM 4.15026097404769 5.50255446055786e-06 yes 7 1.66048205068768e-05 8 3663794
SGTC_259 usnic acid 108.925 µM 4.08645708932867 7.4950612529357e-06 yes 8 2.19005225497612e-05 15 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_796 1234-0020 70.7 µM 4.02604949185305 1.00020538180954e-05 yes 9 2.83608776417289e-05 25 46495034
SGTC_24 0417-1663 219 µM 3.77105770834639 3.23830020237138e-05 yes 10 8.12785359385118e-05 21 4329390
SGTC_2715 st079500 56.4 µM 3.7150712594398 4.15235748064578e-05 yes 11 0.000101573218824386 14 28246688
SGTC_2914 7968218 45.32 µM 3.7027372005131 4.38416734542447e-05 yes 12 0.000106642894066719 17 2977111
SGTC_2576 guaiol 23.12 µM 3.68503512221272 4.73831636009318e-05 yes 13 0.000114335552337026 29 227829
SGTC_1248 0469-0687 58.6 µM 3.62354372678208 6.18994403814485e-05 yes 14 0.000145297024636041 38 4017482
SGTC_2701 st077767 14.721 µM 3.49392667450304 0.000107300365805686 yes 15 0.000237985864266653 64 5721188
SGTC_1933 st074711 15.9 µM 3.48131136996361 0.000113093989868849 yes 16 0.000249482543953167 64 17250958
SGTC_2611 pyromycin 23.93 µM 3.45460766307615 0.000126339953026338 yes 17 0.000275547067146725 57 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1746 st038117 42 µM 3.42182675134574 0.000144590237267735 yes 18 0.000311009673395923 52 2898218
SGTC_646 4092-0839 27.3 µM 3.42153773599188 0.000144761609453912 yes 19 0.000311340416485296 44 877796
SGTC_2505 galangin 7.89 µM 3.39174113263823 0.000163487019646256 yes 20 0.000347250111134736 21 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2129 girgensonine 121.053 µM 3.38365702441276 0.000168945254307421 yes 21 0.000357636466255952 58 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1286 0929-0070 131 µM 3.36483771470301 0.000182319100299448 yes 22 0.000382943460161789 40 1420408
SGTC_1263 0774-1208 64.8 µM 3.36255413037795 0.000184007633308839 yes 23 0.000386124919930429 72 906585
SGTC_1548 st061468 90.8 µM 3.32887303272345 0.000210672661776089 yes 24 0.000435990730011057 21 390799
SGTC_1268 0828-0275 2.46 µM 3.28122932442196 0.000254597423188462 yes 25 0.000516778366963598 44 745337
SGTC_1596 piperlongumine 63 µM 3.26835818478675 0.00026785152292077 yes 26 0.000540866862634092 39 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_206 4546-0025 72.014 µM 3.26515161858904 0.000271252095817956 yes 27 0.000547027484592378 114 6620745 YIL048W NEO1
SGTC_2708 st078559 56 µM 3.15250741477222 0.000419616937475745 yes 28 0.000809373551979754 23 17250902
SGTC_1120 ficusin 1.78878 µM 3.07033240288538 0.00057202645459039 yes 29 0.00106910326466208 54 6199 A DNA cross-linker.
SGTC_291 SEC14.278 35.5 µM 3.02891927632809 0.000666902158940793 yes 30 0.00122715126300995 45 1068044
SGTC_4 0960-0234 25.671 µM 3.02715429129886 0.00067125128135234 yes 31 0.00123433957686966 44 6821112
SGTC_1533 dihydroergotamine mesylate 29.4 µM 3.02000123511565 0.000689146474973672 yes 32 0.00126386827363943 43 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2628 lathosterol 100 µM 2.99209546035122 0.000763248168960364 yes 33 0.00138534804903496 76 6710616
SGTC_329 k048-0121 21.3 µM 2.97244408591473 0.000819761288918804 yes 34 0.00147719508498888 45 6832902
SGTC_1559 coumarin 343 70.1 µM 2.96985999338298 0.00082747250845263 yes 35 0.00148967750302564 43 108770 A hepatotoxic, DNA x-linker.
SGTC_884 0851-0618 334 µM 2.96665326823919 0.000837134523493814 yes 36 0.00150530132174915 57 9642473
SGTC_1052 3253-3998 198 µM 2.94838819880204 0.000894175479236931 yes 37 0.00159717829595579 79 5450317
SGTC_2347 9049783 174.81 µM 2.92213420648656 0.000982439589757614 yes 38 0.00173820853829612 90 6467988 YPL169C MEX67
SGTC_2570 licareol 100 µM 2.91763775023897 0.000998335198865413 yes 39 0.00176346913169486 78 443158
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.87910567408077 0.00114454640491598 no 40 0.00199402339296661 56 688801
SGTC_952 1185-0122 232 µM 2.86476330028889 0.00120380224970493 no 41 0.00208660526678838 75 678600
SGTC_1284 0929-0043 16 µM 2.8637784879277 0.00120797229586129 no 42 0.00209310323150452 81 1239883
SGTC_1258 0671-0043 57.1 µM 2.86057802841209 0.00122161565115749 no 43 0.00211434739126137 86 4298767
SGTC_270 tamoxifen 5.46 µM 2.84688534814731 0.00128159347999783 no 44 0.00220746298648821 93 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3334 9142812 21.919 µM 2.82933971489109 0.00136238260770653 no 45 0.00233220790081168 79 45283678
SGTC_971 1315-0384 26.7 µM 2.81609486963922 0.00142642156314599 no 46 0.00243056548517776 85 6769120
SGTC_263 alizarin 107.927 µM 2.74772348123524 0.00180286722351879 no 47 0.00300052981883032 158 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2566 crystal violet carbinol 226 nM 2.73491470820835 0.00188271417562297 no 48 0.00311982207541148 110 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_371 0195-0006 7.36 µM 2.70279485987896 0.00209726995349533 no 49 0.00343795840282984 85 3928593
SGTC_1631 benzylvanillin 81.9 µM 2.68917615002048 0.002194757895807 no 50 0.00358143053803077 105 75506
SGTC_2439 5492030 7.2 µM 2.66129156841935 0.00240728904141721 no 51 0.00389207591788884 75 5722370
SGTC_349 k015-0014 24 µM 2.66081808431504 0.00241105338738473 no 52 0.00389755300532857 108 2196908
SGTC_645 0845-0943 5.41 µM 2.64484704442691 0.00254118995125747 no 53 0.00408639254901685 78 1885106
SGTC_2141 5621638 7.665 µM 2.60717802159701 0.00287362508676316 no 54 0.0045645941727632 88 2856238
SGTC_1246 0422-0085 105 µM 2.58836960325674 0.00305387371645546 no 55 0.00482157247060661 134 264295
SGTC_747 3448-8087 38.7 µM 2.58365444288636 0.00310062875353553 no 56 0.00488798434362405 129 5168703
SGTC_2686 alizarin 95.37 µM 2.56476137633153 0.00329450307846488 no 57 0.00516233916860126 116 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1086 cerivastatin 2.18 µM 2.56402482133775 0.00330227745633009 no 58 0.00517330725163043 69 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1487 3970-0795 2.82 µM 2.52633910672616 0.00372274884621376 no 59 0.00576290843341651 97 3765103
SGTC_274 sirtinol 40.1 µM 2.52288128866478 0.00376363683331077 no 60 0.00581988436181048 99 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1194 1488-0194 225 µM 2.49569076149934 0.00409944970645878 no 61 0.00628560704797662 142 1391452
SGTC_3068 9116768 49.47 µM 2.49378907569821 0.00412391014215622 no 62 0.00631938116223466 127 41904888
SGTC_397 arbidol 50 µM 2.42977532901672 0.00502732058999542 no 63 0.00755409246180499 121 131410 A RNA synthesis inhibitor.
SGTC_1449 4112-4002 201 µM 2.42574573978811 0.00508968348515666 no 64 0.00763848457005465 105 2059539
SGTC_290 2043-6722 48.1 µM 2.4251100704834 0.0050995839004846 no 65 0.00765187298470245 126 773758 YLR208W SEC13
SGTC_3277 9138724 49.47 µM 2.4043645904713 0.00543224531814975 no 66 0.00810030342569876 91 15943418
SGTC_414 piperonyl butoxide 100 µM 2.39090461933351 0.0056582667838929 no 67 0.00840345924314174 101 5794 A potent inhibitor of cytochrome P450.
SGTC_893 0958-0369 48.9 µM 2.38485091156894 0.00576261575915593 no 68 0.00854302205332365 152 6819948
SGTC_2341 7987486 176.74 µM 2.38016424751002 0.0058445699540406 no 69 0.0086524614437118 149 1258686
SGTC_1579 chlormadinone acetate 49.4 µM 2.37425523642482 0.00594937156116951 no 70 0.00879219520711775 116 45114258 A steroidal progestin.
SGTC_2260 7964312 200 µM 2.35634485732546 0.00627727904237514 no 71 0.00922788756032942 115 231951
SGTC_299 1273-0059 1.44 µM 2.33792555083834 0.00663109652278941 no 72 0.00969555527478673 131 2848077
SGTC_2934 9036370 36.88 µM 2.33552048123276 0.00667857339170687 no 73 0.00975812361727261 176 6462800
SGTC_333 3486-0131 40.1 µM 2.33514807235333 0.00668595166681195 no 74 0.00976784337593584 113 6744690
SGTC_1611 st001856 99.4 µM 2.33492734316112 0.00669032821871418 no 75 0.00977360833182984 133 647478
SGTC_1966 st070145 16.1 µM 2.3290479397315 0.00680783899621675 no 76 0.00992826308866429 138 3748532
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.32393729521791 0.0069114621372826 no 77 0.0100644275081668 78 88881 An O-methylated flavonoid and antioxidant.
SGTC_1035 k081-0041 55.2 µM 2.31985655783356 0.00699520043360195 no 78 0.0101743191523525 152 731709
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.30399757976145 0.00732919670204075 no 79 0.0106113897235422 144 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3047 9092122 49.47 µM 2.28725192844838 0.007697049243904 no 80 0.0110905612996354 149 17173831
SGTC_3119 9125183 49.47 µM 2.28418910017106 0.00776606109990152 no 81 0.0111802099391999 85 22695334
SGTC_415 dibenzyl ketone 100 µM 2.28103161036619 0.00783777530196033 no 82 0.0112732882159062 126 7593
SGTC_1373 2887-0003 58.5 µM 2.27838281468523 0.00789838453440243 no 83 0.0113518896985181 164 776948
SGTC_2754 granisetron 64.02 µM 2.26686997996718 0.0081666342568974 no 84 0.0116990847920907 184 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2309 7664088 163.95 µM 2.24462498182776 0.00870769793239796 no 85 0.0123961088104284 207 704922
SGTC_2050 5263056 171 µM 2.21036431882113 0.00960252153129751 no 86 0.0135399440295636 209 763468 YGL055W OLE1
SGTC_849 0386-0493 241 µM 2.21022474712244 0.00960632543522233 no 87 0.0135447841468202 148 726119
SGTC_2084 5306078 60.6385 µM 2.20325318369398 0.00979801284910779 no 88 0.0137884543438456 167 679340
SGTC_337 1315-0038 354 µM 2.1919673314297 0.010115409075882 no 89 0.0141909328023828 154 1626437
SGTC_557 1315-0110 16.2 µM 2.18594119093628 0.0102885304072317 no 90 0.0144099540746865 177 6833801
SGTC_42 0133-0086 60.653 µM 2.1655311754722 0.0108942140819884 no 91 0.0151735153036987 166 162923 Model of phenazepam hydroxylation.
SGTC_3105 9121040 49.47 µM 2.14986051561073 0.0113800880537681 no 92 0.0157831248317445 63 41448907
SGTC_3034 9090421 49.47 µM 2.12570616080225 0.0121658691721254 no 93 0.0167638668204323 134 17173761
SGTC_1738 st035555 74 µM 2.12419364773686 0.0122166017143462 no 94 0.0168269770947473 218 5331140
SGTC_16 erodoxin 22.806 µM 2.11731718550256 0.0124495693822977 no 95 0.0171164686648767 263 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_57 miconazole 162.5 nM 2.11480990227895 0.0125354656761632 no 96 0.0172230762838519 175 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2555 cholic acid 100 µM 2.09972260095624 0.0130632466841674 no 97 0.0178766251245915 164 6708657 Influences liver metabolism.
SGTC_1150 3909-7983 10.9 µM 2.09443352677797 0.013252761506047 no 98 0.0181106893909422 222 23965914
SGTC_1862 st057513 3.81 µM 2.09392941545176 0.0132709478752955 no 99 0.0181331342280469 158 5393163
SGTC_808 0711-0032 135 µM 2.09033727821877 0.0134011633866881 no 100 0.0182937564155561 171 4252555
SGTC_3261 9137475 49.47 µM 2.07541872009174 0.0139538370833526 no 101 0.0189738723488118 58 17027690
SGTC_256 clotrimazole 625 nM 2.07302293758003 0.0140443981778329 no 102 0.0190850724639141 229 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2532 xanthone 78.9 µM 2.07007983351491 0.0141563411378767 no 103 0.0192224345208163 200 7020 An insecticide.
SGTC_1166 k206-0078 225 µM 2.06180838567439 0.0144750766529781 no 104 0.0196129911966426 223 5404595
SGTC_2859 9028643 45.46 µM 2.05225779148369 0.0148507699182166 no 105 0.0200723078434474 151 17151580
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.04336316098136 0.0152081700005755 no 106 0.0205082507035748 182 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_431 k089-0097 107 µM 2.02943729901939 0.0157825677541334 no 107 0.0212068846404726 288 5499420
SGTC_2969 9091408 28.7 µM 2.02706479568916 0.01588225847422 no 108 0.0213278932838235 243 4286311
SGTC_2155 5570423 76 µM 2.02078698940266 0.0161486552185839 no 109 0.0216509101124812 176 797402
SGTC_1851 st056236 18.9 µM 2.01780384464972 0.0162765801228979 no 110 0.0218058471657718 201 5393171
SGTC_1478 0453-0656 35.7 µM 2.01694360937368 0.0163136300735754 no 111 0.0218506992075855 199 5258496
SGTC_1483 3453-0561 55.9 µM 2.01547245898538 0.016377159257621 no 112 0.0219275844748752 234 4546991
SGTC_2994 9053520 71.4286 µM 2.01233944003845 0.0165131597466896 no 113 0.0220920838001179 209 4647384
SGTC_1301 naphtanilide LB 4.81 µM 2.01016299073519 0.0166082047806028 no 114 0.0222069704983643 194 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_74 000s-0487 160.283 µM 2.0069095536793 0.0167511543974894 no 115 0.0223796472050566 228 677548
SGTC_2843 9000894 45.46 µM 1.98670147441077 0.0176628349616609 no 116 0.023477744171866 119 2242070
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.9858197271697 0.0177035605567022 no 117 0.0235266722494425 280 2724 A muscle relaxant with antifungal properties.
SGTC_522 1273-0010 11.6 µM 1.96315835373809 0.0187780586231335 no 118 0.024813888402449 225 5705015
SGTC_1677 st019204 53.9 µM 1.96061787590669 0.0189019059435914 no 119 0.0249618077550401 231 3945625
SGTC_2539 epi(13)torulosol 80 µM 1.93681691321427 0.0200963152789784 no 120 0.0263838638547849 239 6708597
SGTC_1610 st001799 48.1 µM 1.93261588744604 0.0203136486916295 no 121 0.0266417668983369 192 621897
SGTC_2092 5303694 80.6725 µM 1.92907914759836 0.0204981579362596 no 122 0.0268605186330973 268 1963699
SGTC_2831 7999036 19.48 µM 1.92210254772758 0.0208662876302276 no 123 0.0272964277851308 290 2988270
SGTC_2935 9038016 29.96 µM 1.91763085208738 0.0211051738500169 no 124 0.0275789176251521 253 6463195
SGTC_2163 5671233 125 µM 1.91640020052123 0.0211713221155746 no 125 0.0276570876615802 267 701023
SGTC_1969 st069479 40.1 µM 1.91584519537823 0.0212012113098161 no 126 0.0276924015308753 195 3895485
SGTC_579 4491-1009 110 µM 1.90135606876071 0.0219942290895172 no 127 0.0286276948174876 337 1271041
SGTC_575 k072-0246 11.9 µM 1.89793652486044 0.0221849971773045 no 128 0.0288522220875371 252 6796779
SGTC_403 arphamenine a 50 µM 1.8893279135929 0.0226714417424179 no 129 0.0294239517445277 254 5487158 An arginine aminopeptidase inhibitor.
SGTC_1703 st026983 48.3 µM 1.88815370519598 0.0227384840832052 no 130 0.0295026593812472 244 1104023
SGTC_2144 5628481 200 µM 1.87439642133692 0.0235364905128129 no 131 0.0304379031931323 247 2818399
SGTC_1731 st035964 63 µM 1.86831429607539 0.0238967293213189 no 132 0.0308591375506035 278 6739575
SGTC_1900 st060200 72.8 µM 1.86814552793652 0.0239067910221666 no 133 0.0308708945150195 241 688945
SGTC_2201 6605497 169.863 µM 1.85767117123768 0.0245382613691103 no 134 0.0316078624105941 210 670741
SGTC_2045 5106652 78.05 µM 1.85663518926842 0.0246014717372475 no 135 0.031681536975818 231 673349
SGTC_556 4058-0063 51.5 µM 1.85098502346577 0.0249486256783215 no 136 0.032085853853817 277 6615692
SGTC_3345 9148410 3.559 µM 1.84732693313753 0.0251755670669615 no 137 0.0323498858838589 209 4903596
SGTC_77 0828-0286 12.516 µM 1.84395911574262 0.0253860275062687 no 138 0.0325945493536069 307 745345
SGTC_1177 0983-0204 23.6 µM 1.81934795256427 0.0269691800355103 no 139 0.0344291809402906 270 766818
SGTC_262 fenpropimorph 62.5 µM 1.81911889790056 0.0269842928347869 no 140 0.0344466462572327 260 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1668 st014914 51.6 µM 1.81641645654183 0.0271631315125424 no 141 0.0346532563390431 243 2839556
SGTC_3011 9081274 71.4286 µM 1.81357163438706 0.0273524598229359 no 142 0.0348718503943502 301 6625322
SGTC_1657 st012939 43.4 µM 1.81243394050787 0.0274284829694745 no 143 0.0349595862461276 234 24207257
SGTC_85 0868-0259 160.055 µM 1.81082295782801 0.0275364336055451 no 144 0.035084130676984 237 83173
SGTC_2469 5655019 90.81 µM 1.80588246241838 0.0278697030569773 no 145 0.0354683505228222 294 2788239
SGTC_2215 7188065 200 µM 1.79504407763054 0.0286126063076013 no 146 0.0363233387543133 197 940217
SGTC_871 0574-0004 149 µM 1.79452314710655 0.0286487237468145 no 147 0.0363648537235165 328 9551173
SGTC_1461 k072-0203 53.8 µM 1.79018155518269 0.0289512146074541 no 148 0.0367123646444784 276 5418714
SGTC_2130 NSC 7 2.4545 µM 1.79015628759251 0.0289529828104931 no 149 0.0367143950420809 307 21448
SGTC_2689 tacrolimus 100 µM 1.78714420160722 0.0291644098488161 no 150 0.0369570924871382 313 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1106 tegaserod maleate 11.7 µM 1.78465206783214 0.0293403080902614 no 151 0.0371588851038029 318 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1039 k821-0043 94 µM 1.78292094088565 0.029463011225632 no 152 0.0372995868651139 293 15992768
SGTC_1720 st037298 9.481 µM 1.77563580034319 0.0299840635348654 no 153 0.0378964826340021 296 597396
SGTC_293 4049-0273 38.5 µM 1.77126287493894 0.0303004805962088 no 154 0.0382584989897339 253 1380311
SGTC_763 3453-1109 128 µM 1.76228741390618 0.0309586008059221 no 155 0.0390103746485185 303 1560353
SGTC_1971 st069429 63.5 µM 1.75807664998383 0.0312714048940042 no 156 0.0393672340920227 253 1246522 YGL099W LSG1
SGTC_768 0384-0033 77.3 µM 1.75279337040386 0.0316675754561261 no 157 0.039818740771477 375 3965305 YMR134W ERG29
SGTC_2289 7946404 165.07 µM 1.74806207165303 0.0320258668157126 no 158 0.0402266398591924 415 1246120 YPR165W RHO1
SGTC_353 1988-1175 58.3 µM 1.74661411646252 0.0321361840586046 no 159 0.0403521484319889 277 2788357
SGTC_2693 st077581 40.7 µM 1.73921137070752 0.0327050990189297 no 160 0.0409987950514978 393 25238761
SGTC_2569 tetrandrine 100 µM 1.73843178657663 0.0327654919097026 no 161 0.0410673799168587 273 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_199 4063-0024 41.6 µM 1.73412438165777 0.0331008379586951 no 162 0.0414480081475723 268 306215
SGTC_2627 acetyl isogambogic acid 100 µM 1.72748133093723 0.0336235613503906 no 163 0.0420406275972276 317 6857789 A caspase activator and apoptosis inducer.
SGTC_653 0203-0016 55.2 µM 1.72719014719587 0.0336466283419964 no 164 0.0420667598836524 310 295302
SGTC_195 4234-0266 16.654 µM 1.72494831215326 0.0338246584654699 no 165 0.0422683939321696 366 2303354
SGTC_2450 5739737 12.93 µM 1.71920277423967 0.0342844674235203 no 166 0.0427887279251575 302 2262825
SGTC_2302 7771753 200 µM 1.71140307158092 0.034916877502015 no 167 0.0435033652833151 374 2203047
SGTC_466 geldanamycin 89.2 µM 1.71066703811988 0.0349770473264308 no 168 0.0435712979223593 208 5288382 HSP90 inhibitor.
SGTC_1496 4469-0713 57.4 µM 1.70991499925589 0.0350386134434079 no 169 0.0436407961903537 313 746691
SGTC_2955 9076254 12.21 µM 1.70819869080194 0.0351794531939063 no 170 0.0437997406877662 296 16459619
SGTC_2060 5238662 140 µM 1.69075803329097 0.0366371327010014 no 171 0.0454415127187443 323 790130
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.67121360381392 0.0383289677754548 no 172 0.0473397470818284 426 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.66753987221949 0.0386539830557912 no 173 0.0477035514716485 385 165506
SGTC_1935 st074532 41.6 µM 1.66408564781529 0.0389616233855809 no 174 0.0480476573856259 415 2829742
SGTC_1416 3966-0321 25.3 µM 1.65425468268753 0.0398481144490975 no 175 0.0490378882348703 354 582530 YLR208W SEC13
SGTC_1469 k284-2957 126 µM 1.65396426633416 0.0398745495498678 no 176 0.0490673866928666 306 23884841
SGTC_1128 3448-9350 235 µM 1.6529710857061 0.0399650614016452 no 177 0.0491683741587643 337 619386
SGTC_25 0118-0223 35.662 µM 1.64357314651814 0.0408298173246714 no 178 0.0501322023069404 336 5333628
SGTC_1691 st019933 84.6 µM 1.63745664601065 0.0414007413996405 no 179 0.0507675452622634 309 6176082
SGTC_904 1141-0088 396 µM 1.63340527919576 0.0417824521147259 no 180 0.0511918937334439 341 1378119
SGTC_2102 5377816 72.7585 µM 1.63212750259291 0.0419034308698936 no 181 0.0513263145571017 364 1379702
SGTC_3194 9111903 49.47 µM 1.63106442904736 0.0420042977232954 no 182 0.0514383626757648 366 17087251
SGTC_3043 9092303 49.47 µM 1.61901922525648 0.0431609588493544 no 183 0.0527215633333783 344 25236084
SGTC_2974 9094440 9.66 µM 1.61867114722314 0.0431947622944761 no 184 0.0527590190106625 415 25236134
SGTC_1013 4112-3890 241 µM 1.61678648815315 0.0433781616168695 no 185 0.0529621885218588 383 705171
SGTC_67 0335-0847 266 µM 1.61468241083444 0.0435836550941353 no 186 0.0531897442528702 535 4552207 YOR254C SEC63
SGTC_3219 9131112 49.47 µM 1.61277320502005 0.0437707957564808 no 187 0.0533968947611029 353 17612988 YMR079W SEC14
SGTC_1766 st045414 44.774 µM 1.60961247703364 0.0440820353457784 no 188 0.0537412413242094 394 253960
SGTC_983 1491-0821 12.2 µM 1.60795897095222 0.0442455670305383 no 189 0.0539220824893213 325 46495113
SGTC_686 1319-0111 510 µM 1.60453924677102 0.044585329007733 no 190 0.0542976203580293 382 4562600
SGTC_1524 corynanthine 62.1 µM 1.60409848791036 0.044629272482557 no 191 0.0543461725765922 354 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2764 methyldopa 94.69 µM 1.60212171342198 0.0448267853283706 no 192 0.0545643486633267 394 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2115 tiliquinol 12.7705 µM 1.59814560357618 0.0452261965848859 no 193 0.0550052882290005 313 71208 A bioactive hydroxyquinoline.
SGTC_572 0960-0087 17.7 µM 1.59360944995354 0.0456853570315525 no 194 0.0555117682942297 436 6796365
SGTC_842 0271-0008 11.1 µM 1.58472600366015 0.0465954126331341 no 195 0.0565143005234615 401 1221709
SGTC_2239 6685329 187.64 µM 1.57849218505766 0.0472426732368642 no 196 0.0572262910430291 399 805680
SGTC_1307 1187-1599 12.2 µM 1.5767185959666 0.0474281369035637 no 197 0.0574301447849609 363 1538471
SGTC_913 3487-1245 167 µM 1.57649084664257 0.0474519947880652 no 198 0.0574563632992763 391 4016153
SGTC_1337 1486-1011 40.3 µM 1.57401699556839 0.0477117630320044 no 199 0.0577417601702544 343 X1337
SGTC_120 rhodamine 6G 52.259 µM 1.57320736846556 0.0477970253333779 no 200 0.0578354048513961 475 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1221 2958-7315 257 µM 1.57277937456099 0.0478421468876533 no 201 0.057884956540965 393 4562705
SGTC_1454 4239-0054 42.6 µM 1.57155617971137 0.0479712910828875 no 202 0.0580267579063276 434 1340767
SGTC_1939 st074455 53.6 µM 1.56968282535818 0.0481696195010688 no 203 0.0582444593816625 402 1644229
SGTC_2186 6124449 200 µM 1.56490838636371 0.0486780476670548 no 204 0.058802196005113 363 3834182 YLR033W RSC58
SGTC_11 0438-0307 1.3 µM 1.56404260671815 0.0487707020476469 no 205 0.0589037814379933 355 4011476
SGTC_3164 9100705 49.47 µM 1.56313868226344 0.048867588975484 no 206 0.0590099894398813 306 17174235
SGTC_218 alverine citrate 93.75 µM 1.5598120817138 0.0492254750801282 no 207 0.0594021477659366 347 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2926 9010726 65.15 µM 1.55394592179342 0.0498616719331079 no 208 0.0600986582925858 410 2994293
SGTC_41 0478-0632 82.643 µM 1.5537011442881 0.0498883604209238 no 209 0.0601278600046769 460 3750424
SGTC_373 0844-0104 25.9 µM 1.55341023923085 0.0499200930855441 no 210 0.0601625791328157 405 5375804
SGTC_626 0214-0009 33 µM 1.54825606776538 0.0504849969442579 no 211 0.060780328577641 396 3437874
SGTC_280 3448-3607 3.04 µM 1.54652509166058 0.0506758525589186 no 212 0.0609889025138703 354 626179
SGTC_2402 5553605 200 µM 1.54226253230943 0.051148288096384 no 213 0.0615049049247437 412 6758546
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.54155542892844 0.0512269968727193 no 214 0.0615908318065722 294 77254
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.53890608092983 0.0515227571805372 no 215 0.0619136132115609 398 390807
SGTC_2337 9009472 200 µM 1.53846040416743 0.0515726435237145 no 216 0.0619680414092231 446 5742383
SGTC_2741 miltefosine 3.04 µM 1.53198305245757 0.0523020226740444 no 217 0.0627633084673433 325 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3287 9117173 37.0625 µM 1.5290163737788 0.0526388077196537 no 218 0.0631301924187043 317 2789709
SGTC_306 1672-3436 11.6 µM 1.52777602884481 0.0527801240770337 no 219 0.0632840779266218 400 6797378
SGTC_616 4092-0450 108 µM 1.52602675461225 0.0529799357203803 no 220 0.0635016007898221 439 787165
SGTC_2482 5981709 142.65 µM 1.52303665777752 0.0533228695562437 no 221 0.0638747672337772 443 877755
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.52057096153586 0.0536069815219725 no 222 0.0641837692741935 437 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1684 st024538 14.6195 µM 1.51885122684768 0.0538058483287519 no 223 0.0643999740576519 396 6732859
SGTC_584 0986-0246 15.4 µM 1.51773517834072 0.0539352183085174 no 224 0.064540586014453 455 53315 YDR232W HEM1
SGTC_399 oxolinic acid 75 µM 1.51680078637959 0.0540437203393925 no 225 0.0646584942265055 385 4628 A DNA gyrase inhibitor.
SGTC_1523 st012844 44.7 µM 1.51266101053079 0.0545265129081037 no 226 0.0651828940767326 427 4274103
SGTC_1407 3909-7909 12.3 µM 1.51116216541254 0.0547021512480612 no 227 0.0653735696532535 428 4411780
SGTC_2184 6075246 200 µM 1.51028044208216 0.0548056825188734 no 228 0.0654859400357655 405 2267320
SGTC_1402 3909-7673 35.9 µM 1.50184626749499 0.0558038608561697 no 229 0.0665684080873946 405 5328014
SGTC_478 N-arachidonylglycine 10 µM 1.50103123662671 0.055901074351862 no 230 0.0666737412523221 262 5283389
SGTC_2508 celastrol 40.54 µM 1.49816761238875 0.0562436952332546 no 231 0.0670448540280564 361 122724 Celastrol is a natural product and antioxidant.
SGTC_2749 bexarotene 57.39 µM 1.49634148145982 0.0564630474004491 no 232 0.0672823452853424 440 82146 An retinoic acid receptor inhibitor.
SGTC_2158 5657123 3.6195 µM 1.49592973747529 0.0565125985065989 no 233 0.0673359829947281 387 2858827
SGTC_3249 9135183 49.47 µM 1.48699804150184 0.0575959352594287 no 234 0.0685076641068738 435 4902779
SGTC_2592 piperlongumine 83.33 µM 1.48489984203868 0.0578527827025821 no 235 0.0687851789490455 410 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_546 peri-Naphthalide 147 µM 1.48078448152929 0.0583591716843678 no 236 0.0693320065562606 430 223824 A penicillin ester.
SGTC_1404 3909-7820 48.3 µM 1.47822999456298 0.0586752444416454 no 237 0.0696731140446571 417 23741373
SGTC_1370 2001-0092 44.6 µM 1.47474208444446 0.0591089799769156 no 238 0.0701409485294714 513 790957
SGTC_1561 5-methoxyflavone 52.9 µM 1.47457071482588 0.0591303551149497 no 239 0.0701639965169778 338 94525
SGTC_1871 st057448 67.3 µM 1.47386711837245 0.0592181790950775 no 240 0.0702586862668271 456 691747
SGTC_166 k072-0058 166.424 µM 1.47161024541257 0.0595005758362698 no 241 0.0705630786460848 440 5846229
SGTC_2174 5790901 200 µM 1.46968489886564 0.0597423229226268 no 242 0.0708235572597527 434 786020
SGTC_565 1418-0001 44.5 µM 1.46571909446555 0.0602426949471667 no 243 0.0713624150177664 473 2862145
SGTC_2804 7954240 19.48 µM 1.46533968766438 0.0602907367482477 no 244 0.0714141317959795 479 828705
SGTC_1958 st076513 41.9 µM 1.46507155178985 0.0603247071209167 no 245 0.0714506986266158 464 732122 YGL099W LSG1
SGTC_2366 9070441 60.58 µM 1.45637500844638 0.0614346228504707 no 246 0.0726444901768735 462 6837235
SGTC_692 k241-0027 77.8 µM 1.45270634155951 0.061907601845459 no 247 0.073152652755897 426 3600480
SGTC_317 4495-0002 170 µM 1.4506016108614 0.0621802321517272 no 248 0.0734454132479288 394 15991618
SGTC_2520 obtusaquinone 4.71 µM 1.4492924079973 0.0623502879248097 no 249 0.0736279701854429 443 5967872
SGTC_9 0092-0002 10.449 µM 1.44890743799783 0.0624003616247736 no 250 0.0736817168487973 463 759368
SGTC_2324 6149169 200 µM 1.44592251785809 0.0627896800940106 no 251 0.0740994676501597 405 2888231
SGTC_1891 st059073 26.2 µM 1.44291019677167 0.0631844886860423 no 252 0.0745228851783598 480 688754
SGTC_116 0155-0182 31.788 µM 1.44207827027285 0.0632938647328798 no 253 0.0746401471827846 602 771486
SGTC_1481 3346-2004 36 µM 1.44086356161084 0.0634538310532262 no 254 0.074811616076942 455 2770522
SGTC_3108 9121785 49.47 µM 1.43748272979579 0.06390071336869 no 255 0.0752904382884859 439 17140271
SGTC_718 1130-0073 349 µM 1.43527170999149 0.064194289790868 no 256 0.0756048430051106 484 6740020
SGTC_205 1486-1330 71.903 µM 1.43512105978066 0.0642143310233487 no 257 0.075626301654547 377 4118834
SGTC_2899 9053889 58.44 µM 1.43027015398706 0.0648622575832205 no 258 0.0763197486982508 414 6470052
SGTC_211 3455-0679 143.504 µM 1.42900496360072 0.065032078500466 no 259 0.0765014034022955 484 748649
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.42825560665959 0.0651328239792066 no 260 0.0766091502714807 526 65057 A dermal irritant. YDR527W RBA50
SGTC_2522 biochanin a 4.94 µM 1.42647537872355 0.0653726480271339 no 261 0.0768655844885258 414 5280373 A possible chelator.
SGTC_406 estrone 100 µM 1.42575245251003 0.065470232624552 no 262 0.0769699050207609 476 5870 A steroid.
SGTC_2848 9016370 25.97 µM 1.42454704539391 0.0656331963584648 no 263 0.077144088334228 531 7894410
SGTC_1462 k081-0014 26.5 µM 1.42391717687186 0.065718475777795 no 264 0.077235224437822 320 3270634
SGTC_2203 7227154 166.4 µM 1.42362183483644 0.065758492418633 no 265 0.0772779858364505 419 896304
SGTC_2470 5664817 21.68 µM 1.42241974352322 0.0659215617316265 no 266 0.0774522174497938 426 2859561
SGTC_800 3448-7362 155 µM 1.41760012195288 0.0665785144924525 no 267 0.0781537722657866 747 15991913
SGTC_372 0155-0182 15.9 µM 1.41395162679665 0.06707919480667 no 268 0.0786880530085183 496 771486
SGTC_2212 7123476 200 µM 1.41088194131651 0.0675026968285843 no 269 0.0791397138996265 365 1085715
SGTC_21 0849-0113 22.993 µM 1.40841874492483 0.0678440177953517 no 270 0.0795035559344319 491 1560156
SGTC_2478 5763493 32.33 µM 1.40609774023784 0.0681668537536446 no 271 0.0798475516600797 474 1365576 YLR208W SEC13
SGTC_2920 7982904 15.77 µM 1.40357518561877 0.0685190672487645 no 272 0.080222694322176 414 6456808
SGTC_1786 berberine 21.6 µM 1.39788299426792 0.0693190001328792 no 273 0.0810741030887818 488 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1529 apigenin 74 µM 1.39396446735523 0.0698738445600307 no 274 0.081664167449642 519 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.3931969833226 0.0699829157415561 no 275 0.0817801158822462 497 688798
SGTC_88 0180-0332 8.668 µM 1.39009457587266 0.0704251505860003 no 276 0.082250080091056 481 3101745
SGTC_93 0109-0045 59.227 µM 1.38597372108441 0.0710158790862925 no 277 0.0828774639807109 596 88733
SGTC_3263 9137018 49.47 µM 1.38014500549913 0.0718579198238181 no 278 0.0837710013003167 477 43844957
SGTC_1793 st048256 72.231 µM 1.37831468681209 0.0721239089689573 no 279 0.0840530753108137 457 672022
SGTC_3297 9117502 71.43 µM 1.3770875834029 0.0723026586643396 no 280 0.0842425855457966 454 7453720
SGTC_1704 st028805 70.8 µM 1.3767698031731 0.0723490043684604 no 281 0.0842917148262338 480 2876101
SGTC_1157 4092-0394 27.6 µM 1.37227795674039 0.0730065415472763 no 282 0.0849884625466273 562 3659885
SGTC_2384 9036245 200 µM 1.37073177072366 0.073233934452344 no 283 0.085229293512779 513 6462766
SGTC_851 0394-0702 453 µM 1.36978659247217 0.07337320558339 no 284 0.0853767642733489 538 762646
SGTC_250 brefeldin a 552.239 µM 1.3692066820752 0.0734587550591378 no 285 0.0854673389405912 413 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.36783634586481 0.0736612127231032 no 286 0.0856816540414018 520 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_825 1988-2224 89.6 µM 1.36661682247317 0.0738417473305296 no 287 0.0858727207550637 533 1180859
SGTC_856 0433-0016 11.3 µM 1.36563918786546 0.0739867174852066 no 288 0.0860261201012093 535 3911780
SGTC_185 k048-0037 25.491 µM 1.36162474095251 0.0745842869649353 no 289 0.0866581715761167 519 6827589
SGTC_2019 4016004 108 µM 1.35961223369158 0.0748852411179642 no 290 0.0869763323692071 438 45595336
SGTC_1807 st050092 58.9 µM 1.35713359742709 0.0752571731212848 no 291 0.0873693824315479 490 5008496
SGTC_3152 9099253 49.47 µM 1.35092070390693 0.0761956372882199 no 292 0.0883604176346172 624 25236131
SGTC_94 0334-0113 514.748 µM 1.34852991034748 0.0765591330896484 no 293 0.0887440033420263 499 6795178
SGTC_3129 9127257 49.47 µM 1.34410005509999 0.0772361314426487 no 294 0.0894580171505554 438 837894
SGTC_3305 9127027 53.8275 µM 1.34345286443432 0.0773354188019635 no 295 0.089562689483998 512 41905295
SGTC_1729 st035615 45.989 µM 1.34290806486397 0.0774190731845291 no 296 0.0896508723395501 518 17385451
SGTC_1988 st071872 53.4 µM 1.34159244078428 0.0776213716075412 no 297 0.0898640892638384 478 16414116
SGTC_959 1222-0044 107 µM 1.33653432091902 0.0784028779719625 no 298 0.0906873451477287 514 6083612
SGTC_1987 st072290 61.9 µM 1.33468576905148 0.0786899727740227 no 299 0.0909896065820686 534 54697379
SGTC_2560 caryophyllene 100 µM 1.33405792659854 0.0787876627260203 no 300 0.0910924365296378 580 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_855 0428-0020 25 µM 1.33244323479032 0.0790393248017507 no 301 0.0913572914967957 478 6812414
SGTC_1045 1348-1485 165 µM 1.3322904518006 0.0790631686922259 no 302 0.0913823817464761 575 6810614
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.33156093225239 0.0791770953787763 no 303 0.0915022549592186 573 23665772 A membrane-active detergent.
SGTC_821 1114-0266 29.2 µM 1.32989685781271 0.0794374335477034 no 304 0.091776128430329 504 3123235
SGTC_968 1309-0633 340 µM 1.32526823620423 0.0801649708440156 no 305 0.0925411001243615 534 3761976
SGTC_665 3914-0008 307 µM 1.32524277265796 0.0801689871457755 no 306 0.0925453214882088 517 1069549
SGTC_2254 7938975 95.19 µM 1.3246700751765 0.0802593574769668 no 307 0.0926403012975915 639 2969277
SGTC_2518 prenyletin 46.28 µM 1.32461786540754 0.0802675998848329 no 308 0.0926489636841187 419 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2531 methyl deoxycholate 70.07 µM 1.31716140835667 0.0814513395405491 no 309 0.0938922633309486 514 16667744 Haematoxylin.
SGTC_2640 pentamidine 10.38 µM 1.3163594006628 0.0815794413182396 no 310 0.0940267211727699 592 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2183 6420625 130.508 µM 1.31565898179733 0.0816914408982761 no 311 0.0941442636670186 624 2897619
SGTC_464 bw-b 70c 158 µM 1.31284221282414 0.0821430233716136 no 312 0.0946180612279473 580 5353454
SGTC_3213 9129884 49.47 µM 1.3121522361083 0.0822539261546104 no 313 0.0947343870251423 458 17190742
SGTC_998 3996-0085 177 µM 1.31016309345258 0.0825742803557799 no 314 0.0950703340129083 598 715391
SGTC_846 0335-0850 148 µM 1.3081474136475 0.0828998655194151 no 315 0.0954116571478673 496 6819598
SGTC_2953 9074162 66.49 µM 1.30791264006678 0.0829378503178224 no 316 0.0954514708750228 506 16451992
SGTC_3284 9108171 64.8615 µM 1.30587905367404 0.083267419053708 no 317 0.0957968454044354 497 8687505
SGTC_2467 5474540 200 µM 1.30566821259681 0.0833016448048502 no 318 0.0958327061672071 545 5413519
SGTC_2888 9058547 12.99 µM 1.30410139244646 0.0835563175058834 no 319 0.0960995071045446 452 16476514
SGTC_2659 sanguinarine 24.21 µM 1.30293685507814 0.0837459814146835 no 320 0.0962981601140013 542 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_128 0906-2981 13.371 µM 1.30062681545794 0.0841231657929158 no 321 0.0966931118629562 483 6740226
SGTC_2231 micatex 6.853 µM 1.29751684412796 0.0846329756859236 no 322 0.0972267066477272 499 20737 An antifungal of unknown mechanism.
SGTC_1859 st055998 20 µM 1.29338679146638 0.0853135824702377 no 323 0.0979386580682964 574 676301
SGTC_1236 0330-0013 258 µM 1.29125422466613 0.0856666173864748 no 324 0.0983077689346435 532 4617066
SGTC_138 0850-0259 40.9225 µM 1.29020239701384 0.0858411440246325 no 325 0.0984901970601388 687 6813004
SGTC_2013 4024628 200 µM 1.28964237627687 0.0859341750995752 no 326 0.098587427653361 522 5230760
SGTC_2312 7706453 155.7 µM 1.28756045618879 0.0862806869279247 no 327 0.0989495060114738 544 976098
SGTC_3002 9075603 71.4286 µM 1.28713109037827 0.0863522797640428 no 328 0.09902430027286 574 20105405
SGTC_1796 st049173 110.4 µM 1.28616414671038 0.0865136714641519 no 329 0.0991928904334585 494 94134
SGTC_1740 st038286 13.222 µM 1.2857794194798 0.0865779486141012 no 330 0.0992600273690565 560 716786
SGTC_1169 aniline yellow 25.8 µM 1.27988631867698 0.0875669866549423 no 331 0.10029255997743 521 6051 A DNA damaging agent.
SGTC_2881 9058953 51.95 µM 1.27978449268213 0.0875841498845398 no 332 0.100310469589537 575 17122249
SGTC_2919 7978188 46.38 µM 1.27945989701326 0.0876388787000975 no 333 0.100367576509574 581 2980291
SGTC_180 1486-1293 102.781 µM 1.27616312872096 0.0881961803635809 no 334 0.100948929764736 557 4140536
SGTC_2351 9026858 72.31 µM 1.27495916264005 0.0884003617712202 no 335 0.101161848344916 517 1409300
SGTC_1925 st057770 10.1 µM 1.27244735097282 0.0888274751950427 no 336 0.101607109594995 514 5989122
SGTC_2670 beta-carotene 100 µM 1.27016009676943 0.0892177393556065 no 337 0.102013804124246 467 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3252 9135871 49.47 µM 1.27009561810545 0.0892287595279525 no 338 0.102025286157153 560 17682838
SGTC_1836 st055642 81 µM 1.26739975107244 0.0896904222591085 no 339 0.102506194385563 572 8571
SGTC_316 k060-0003 58.6 µM 1.26688518853442 0.0897787417041016 no 340 0.102598172765893 553 6152314
SGTC_2154 5570129 200 µM 1.26151367721925 0.0907045700895334 no 341 0.103561917699146 614 673366
SGTC_2252 omeprazole 400 µM 1.25787088507439 0.0913364581125794 no 342 0.104219227344269 470 4594 A proton pump inhibitor.
SGTC_550 4123-0385 25.7 µM 1.25779822250735 0.091349095459784 no 343 0.104232369353885 566 5731123
SGTC_874 0599-0792 117 µM 1.25503279963798 0.0918310169101648 no 344 0.104733426681878 664 765305
SGTC_745 0469-0705 296 µM 1.25344008810899 0.0921094269494715 no 345 0.105022794962912 660 3486736
SGTC_198 3454-2873 16.191 µM 1.2518813876937 0.0923824963164788 no 346 0.105306543878819 578 710957
SGTC_1562 morin hydrate 59.1 µM 1.25085868228674 0.0925619896922794 no 347 0.105493020292701 554 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3114 9122766 49.47 µM 1.24734013311997 0.093181495231437 no 348 0.106136403880371 541 17176985
SGTC_1159 4092-0538 61.2 µM 1.24363202381455 0.0938376867079894 no 349 0.106817512232787 634 717301
SGTC_3299 9121982 43.1275 µM 1.24242594318602 0.0940518495878499 no 350 0.107039724304561 597 17594604 YPL160W CDC60
SGTC_342 k048-0088 23.3 µM 1.24124636059431 0.0942616558674472 no 351 0.107257376619324 580 6820570
SGTC_3208 9114115 49.47 µM 1.23824985999745 0.094796179943781 no 352 0.107811714502511 528 650895
SGTC_1641 st009299 47.1 µM 1.23675214997565 0.0950641813157621 no 353 0.10808955569939 514 4046054
SGTC_1330 1469-0054 61.8 µM 1.23665105106731 0.0950822921179293 no 354 0.108108329181926 590 7102664
SGTC_2515 chrysin 20.77 µM 1.23524760064335 0.0953339679985871 no 355 0.108369184316709 605 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1442 4112-3290 3 µM 1.23429499895863 0.0955050739434533 no 356 0.108546499396548 619 704353
SGTC_2781 5567276 71.43 µM 1.2340576448459 0.0955477425500801 no 357 0.108590712404521 564 2853274
SGTC_3354 9151612 71.43 µM 1.23121569013674 0.0960597242911464 no 358 0.109121102325938 639 27261949
SGTC_601 0986-0029 62.9 µM 1.23108663095522 0.0960830222553561 no 359 0.109145232568882 629 24747981
SGTC_1182 1222-0449 220 µM 1.22924318606165 0.0964162574035728 no 360 0.109490320760883 568 658318
SGTC_2297 7971671 152.32 µM 1.22486809788471 0.0972105297202182 no 361 0.110312461050528 580 909016
SGTC_2876 9059903 25.97 µM 1.22446917504602 0.0972831900449424 no 362 0.110387643878015 646 6916095
SGTC_519 k048-0011 62.8 µM 1.22247912983459 0.0976462547362969 no 363 0.110763245732499 594 6836379
SGTC_1491 4138-0063 26.5 µM 1.22232506740035 0.0976744033317537 no 364 0.110792361677415 557 23883227
SGTC_221 trifluoperazine 10.304 µM 1.22166630886844 0.0977948315640147 no 365 0.110916920963527 752 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_578 3460-0051 92 µM 1.22156746035732 0.0978129115357516 no 366 0.110935620075752 663 2876744
SGTC_153 4077-0274 519.67 µM 1.21855895820485 0.0983643568926999 no 367 0.111505817206151 554 3121976
SGTC_1122 capsaicin 818.572 nM 1.21685930653265 0.098676900347168 no 368 0.111828875366408 614 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_379 3970-0972 5.9 µM 1.21579876659593 0.0988722875239911 no 369 0.112030794392954 596 2898042 YBL034C STU1
SGTC_3268 9137683 49.47 µM 1.21537383507508 0.0989506536030308 no 370 0.112111771336902 557 1953228
SGTC_1914 st062367 72.6 µM 1.21484337428381 0.0990485451982385 no 371 0.112212917138707 580 978205
SGTC_629 3448-6466 76.7 µM 1.21231335217924 0.0995164119092458 no 372 0.112696227341689 634 573744
SGTC_712 r015-0009 80.6 µM 1.21104280936818 0.0997519765561237 no 373 0.112939499086762 551 6813872 YLR060W FRS1
SGTC_2913 7966556 36.57 µM 1.21079081772246 0.0997987453680583 no 374 0.112987792618751 571 2976516
SGTC_2641 levomentholum 100 µM 1.20909136624025 0.100114576251762 no 375 0.113313872902446 563 16666
SGTC_1331 1472-0049 76.2 µM 1.20902642329143 0.100126659892772 no 376 0.11332634705784 580 24051409
SGTC_1791 st048313 56.1 µM 1.2077094034815 0.100371941612753 no 377 0.113579529852488 560 1204976
SGTC_1604 st002052 72.4 µM 1.20657580067811 0.100583414655728 no 378 0.113797775449786 624 6254834 YHR062C RPP1
SGTC_346 4513-0042 7.16 µM 1.20488042663396 0.100900292102103 no 379 0.114124732902889 632 2827372
SGTC_2805 7950783 58.44 µM 1.20274489894071 0.10130047239801 no 380 0.114537526683142 673 1178958 YDL195W SEC31
SGTC_445 e6 berbamine 66 µM 1.20242241261731 0.101361004034798 no 381 0.114599954968984 736 6610268 A calcium/calmodulin antagonist.
SGTC_1655 st012546 55.1 µM 1.19371376917463 0.103005618614987 no 382 0.116294976255155 576 720985 YLR208W SEC13
SGTC_425 3825-7017 13.1 µM 1.19212308205109 0.103308099453992 no 383 0.116606493806532 670 3397440
SGTC_2616 abietic acid 100 µM 1.19120007240015 0.103483911913664 no 384 0.116787525571856 666 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_640 3381-0960 37.1 µM 1.18560488399111 0.104554318281216 no 385 0.117889186301233 676 1745025
SGTC_1309 pyrazolanthrone 13.4 µM 1.18513208024801 0.104645135771931 no 386 0.117982614445873 677 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_967 1306-0166 352 µM 1.18451469774044 0.104763810363031 no 387 0.118104690838874 626 4437607
SGTC_97 0535-0701 19.132 µM 1.18317304111792 0.105022042444959 no 388 0.118370287476545 592 2832013 YGL099W LSG1
SGTC_2839 9003951 25.97 µM 1.18291670641045 0.105071432219573 no 389 0.118421079936769 593 2990634
SGTC_150 3970-0969 77.2 µM 1.17821166422645 0.105980973048711 no 390 0.119356116795769 722 6615640
SGTC_1574 spiramycin 23.7 µM 1.17745551460478 0.106127674846056 no 391 0.119506871608855 643 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_877 0771-0151 33.1 µM 1.17619988134823 0.106371606232126 no 392 0.1197575059548 671 6166523
SGTC_119 0121-0043 24.815 µM 1.172459365951 0.107100673644687 no 393 0.120506338466738 809 1092378
SGTC_1710 st031758 61.5 µM 1.16922513735433 0.107733959597907 no 394 0.1211564679593 618 5394341
SGTC_1032 k061-1018 98.7 µM 1.16867168886551 0.107842598666665 no 395 0.121267966327807 727 4005393
SGTC_3190 9110366 49.47 µM 1.1680557527879 0.107963596470848 no 396 0.121392138336161 547 17123768
SGTC_1161 k007-0610 110 µM 1.16734705998818 0.108102936819774 no 397 0.121535120562771 736 5843850
SGTC_39 0986-0283 58.349 µM 1.16719652447776 0.108132551174459 no 398 0.121565507072611 727 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_669 0108-0021 26.2 µM 1.1655611729347 0.108454644892864 no 399 0.121895956876639 759 17201
SGTC_1357 1503-1303 39.5 µM 1.16447208054231 0.108669531693927 no 400 0.12211637572114 686 292895
SGTC_661 1304-0007 33.6 µM 1.16236621114582 0.109085905009537 no 401 0.12254337108405 637 3117130
SGTC_1001 4048-4355 44.4 µM 1.16002170013804 0.109550810028575 no 402 0.123019985579715 643 21824233
SGTC_2946 9065502 71.43 µM 1.15950782366838 0.10965289902903 no 403 0.123124624673179 487 16489101
SGTC_3270 9137563 49.47 µM 1.15681433881167 0.110189116112101 no 404 0.123674111139726 586 17015724
SGTC_1476 4112-3294 3.34 µM 1.15348045367003 0.110855425029071 no 405 0.124356617932793 635 704369
SGTC_2785 7756463 72.73 µM 1.15243851977238 0.111064256348591 no 406 0.124570459943584 635 2201551
SGTC_822 1487-0950 154 µM 1.15090359447614 0.111372409276493 no 407 0.124885949436609 657 1958375
SGTC_2729 fluphenazine 10.66 µM 1.14868328167633 0.111819243324237 no 408 0.125343301019716 668 3372 An atypical antipsychotic.
SGTC_1305 1181-0477 144 µM 1.14766724349966 0.112024146277581 no 409 0.125552979322901 657 6252086
SGTC_1180 1193-0155 285 µM 1.14683136775471 0.112192917287246 no 410 0.125725661186521 619 2921347
SGTC_183 3914-0051 30.55 µM 1.14492734692739 0.112578034887308 no 411 0.12611962730713 658 1596232
SGTC_139 0099-0334 718.624 µM 1.14186974402917 0.113198456247585 no 412 0.126754083340232 773 97690
SGTC_1217 1183-1422 255 µM 1.1410997553057 0.113355079238914 no 413 0.126914206557587 721 2849664
SGTC_1455 4262-0120 131 µM 1.14095928562813 0.113383668763356 no 414 0.126943433148168 697 1529587
SGTC_2910 7948405 25.97 µM 1.14078280574603 0.113419594664625 no 415 0.126980158782088 606 2971328
SGTC_1893 st059353 36.1 µM 1.13953709822097 0.113673413488767 no 416 0.127239602052828 655 3112488
SGTC_1206 3978-0017 132 µM 1.13582713031725 0.114431734999405 no 417 0.128014460096637 626 3873677
SGTC_2941 9056145 11.23 µM 1.13459090328138 0.114685219321862 no 418 0.128273383178508 574 2119517
SGTC_3207 9114163 49.47 µM 1.13166115516478 0.115287549455209 no 419 0.128888459278877 733 849233
SGTC_3040 9091894 49.47 µM 1.13095870070376 0.115432301443773 no 420 0.129036237252769 602 25236966
SGTC_1743 st037606 46.3785 µM 1.12983212197047 0.115664720612454 no 421 0.129273485070172 670 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1269 0831-0796 3.05 µM 1.12866669324069 0.115905504346678 no 422 0.129519232346726 677 927758
SGTC_1519 esterone 74 µM 1.12842359238071 0.115955775099016 no 423 0.129570534402075 678 698 A steroid.
SGTC_500 h-89 112 µM 1.12568907683299 0.11652231131075 no 424 0.13014857443584 731 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2626 ethyl orsellinate 100 µM 1.12434462418339 0.116801573403739 no 425 0.130433427159347 645 75653 A natural product.
SGTC_1826 st055655 41.6 µM 1.1238049398486 0.11691380692533 no 426 0.130547892699192 700 676168
SGTC_2858 9025781 8.96 µM 1.12158999973659 0.117375229546293 no 427 0.131018402768617 790 4894980 YPL153C RAD53
SGTC_731 3966-0296 387 µM 1.12016241465682 0.117673310748517 no 428 0.13132227863779 684 660956
SGTC_247 mechlorethamine 29.705 µM 1.11711345970878 0.118311728783496 no 429 0.131972908113086 631 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1916 st067606 49.2 µM 1.1160194814065 0.118541391801983 no 430 0.132206897857456 730 19590279
SGTC_872 0588-0139 234 µM 1.11488592928363 0.118779694871726 no 431 0.132449653551627 706 2047100
SGTC_1400 3771-8998 51.5 µM 1.11139619129881 0.119515455311395 no 432 0.133198925511162 636 670767
SGTC_367 0335-0881 7.1 µM 1.11069859978232 0.119662917090102 no 433 0.13334905257466 718 23828853
SGTC_540 1187-0821 17.3 µM 1.1105866041679 0.11968660345638 no 434 0.133373165733124 670 847520
SGTC_20 0481-0013 4.944 µM 1.11029625737388 0.119748025369792 no 435 0.133435692668629 681 182045
SGTC_227 fluconazole 33.516 µM 1.11001145449039 0.1198082960789 no 436 0.133497045294994 740 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1725 st036284 20.55 µM 1.10761398392816 0.12031650283076 no 437 0.134014280765717 763 707914
SGTC_2480 5767542 37.17 µM 1.10756557654892 0.120326779660982 no 438 0.134024738440856 718 2867358
SGTC_1992 st073643 23.3 µM 1.10672085789073 0.120506211996565 no 439 0.134207317274481 675 3161292
SGTC_1076 itraconazole 331 nM 1.09976087235317 0.121991802959774 no 440 0.135718162276415 720 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_92 0063-0024 660.874 µM 1.09962779172408 0.122020333450299 no 441 0.135747163929557 769 3594437
SGTC_3216 9129716 49.47 µM 1.09685577916624 0.122615676962434 no 442 0.13635222107793 648 8056934
SGTC_165 k038-0023 64.381 µM 1.09591444421617 0.122818309649283 no 443 0.136558108668934 702 46368543
SGTC_3015 9080845 49.47 µM 1.09495639342072 0.123024781616419 no 444 0.136767870530559 751 5296973
SGTC_2314 7727897 200 µM 1.09464240939193 0.123092502024859 no 445 0.136836664131005 684 900724
SGTC_2476 5806916 10.51 µM 1.09335773929925 0.123369853177764 no 446 0.13711838045635 697 2870194
SGTC_542 3381-0244 89.3 µM 1.09069032867177 0.123947125728536 no 447 0.137704583814455 787 1112843
SGTC_887 0885-0007 9.62 µM 1.08809188470133 0.124511287922607 no 448 0.138277272979199 744 5719458
SGTC_3254 9136651 49.47 µM 1.08487962064458 0.125211198205844 no 449 0.138987487580796 753 16454030
SGTC_946 3434-1334 87.4 µM 1.08322512306234 0.125572761467841 no 450 0.139354255538537 697 4047976
SGTC_935 2996-0153 430 µM 1.08177753592391 0.125889704893886 no 451 0.13967569535321 731 23738523
SGTC_1338 1486-1223 76 µM 1.07989702780814 0.126302267145751 no 452 0.14009401848243 758 3444526
SGTC_592 k241-0073 46.5 µM 1.07948914201032 0.126391876890963 no 453 0.140184865786244 762 4230158
SGTC_700 3453-2283 142 µM 1.07740101041327 0.126851319088673 no 454 0.140650576463773 773 565664
SGTC_549 1661-1316 519 µM 1.07724384036999 0.126885947496051 no 455 0.140685672140765 760 2857282
SGTC_1457 k015-0032 57.3 µM 1.07633686448779 0.127085905036239 no 456 0.140888313679629 734 4302660
SGTC_1678 st019265 80.2 µM 1.07625017756781 0.127105028047798 no 457 0.140907692109831 755 5367020
SGTC_2898 9056270 58.44 µM 1.07615754405304 0.127125465082717 no 458 0.140928401870076 654 19154699
SGTC_2205 7238770 200 µM 1.07257426785837 0.127917771733593 no 459 0.141731087624953 716 279867
SGTC_1403 3909-7815 62.9 µM 1.07155908917669 0.128142862690497 no 460 0.141959058506586 684 6615483
SGTC_668 1682-0499 62.6 µM 1.07131327562926 0.128197407156975 no 461 0.142014296280648 775 682214
SGTC_412 gemfibrozil 100 µM 1.06959085679862 0.128580053280765 no 462 0.142401756254656 690 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1841 st054148 70 µM 1.06890189280004 0.128733332657851 no 463 0.142556939490055 674 675442
SGTC_2928 9011484 9.79 µM 1.06833922304706 0.128858608345307 no 464 0.142683760838616 680 2994751
SGTC_2265 7929201 200 µM 1.06798676808431 0.128937123792084 no 465 0.14276324026685 719 1265108
SGTC_402 epigallocatechin gallate 10 µM 1.06668449481933 0.129227515465201 no 466 0.143057165516827 749 65064 An antioxidant.
SGTC_2861 9024595 19.48 µM 1.06631558505142 0.129309860358613 no 467 0.143140503329741 633 16482810
SGTC_2369 9071472 200 µM 1.06373609535349 0.129886648174172 no 468 0.143724133989433 754 17296037
SGTC_1302 1159-0335 255 µM 1.06196347379797 0.130284047049823 no 469 0.144126133747226 716 649284
SGTC_1968 st069590 43.6 µM 1.05923668528641 0.130896998669978 no 470 0.144746000826905 723 6384066
SGTC_384 k007-0144 5.16 µM 1.05326190845304 0.132247020811633 no 471 0.146110485866818 784 6824886
SGTC_740 k014-0057 261 µM 1.05090567114523 0.132782050864562 no 472 0.146650957744598 829 4012779
SGTC_2377 9073351 62.6 µM 1.04831109150826 0.133372923582533 no 473 0.147247650546401 714 7337946 YHR072W ERG7
SGTC_2746 daunorubicin 9.88 µM 1.04766791508671 0.133519675745033 no 474 0.147395817474113 634 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_485 niflumic acid 177 µM 1.04729114870523 0.133605693270681 no 475 0.147482658581773 717 4488 A COX2 inhibitor.
SGTC_1312 1218-2183 165 µM 1.04589259399392 0.13392532305148 no 476 0.14780531203121 789 6744073
SGTC_2012 4023501 200 µM 1.04313817179104 0.134556362383101 no 477 0.148442151922473 689 3477460
SGTC_2847 9005661 71.43 µM 1.04291069459954 0.134608568595907 no 478 0.14849482800229 651 2991449
SGTC_1116 jasmonic acid 1.58368 µM 1.03832885052272 0.135663066448652 no 479 0.149558490711168 780 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2767 sibutramine 71.45 µM 1.03400661061394 0.136662991256615 no 480 0.150566536411717 793 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3313 9133968 57.047 µM 1.03207351927398 0.137111827442289 no 481 0.151018838964472 816 1494643
SGTC_945 3381-0768 11.3 µM 1.03023814799391 0.137538905452416 no 482 0.151449113031805 822 1126236 YIL048W NEO1
SGTC_2918 7977171 22.06 µM 1.03009755743666 0.137571657291689 no 483 0.151482105865633 761 2236483
SGTC_2151 5563267 85.4165 µM 1.02662890827354 0.138381396594205 no 484 0.152297618188919 797 5310824
SGTC_1054 3429-0080 167 µM 1.0246605093908 0.138842351697249 no 485 0.152761701312672 797 1162877
SGTC_1876 myriocin 605 nM 1.02410322886008 0.138973044069186 no 486 0.152893259746876 791 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3086 9117350 49.47 µM 1.02379996698735 0.139044199647083 no 487 0.152964882995894 730 2679265
SGTC_2424 5537928 59.2 µM 1.0203563337509 0.139853933219346 no 488 0.153779747610602 800 5382802
SGTC_3187 9109394 49.47 µM 1.01975832213109 0.139994875234126 no 489 0.1539215469813 778 17098090
SGTC_799 1310-0557 151 µM 1.01917653997884 0.140132084811448 no 490 0.15405958106178 780 5354492
SGTC_513 4245-1575 41.7 µM 1.01718110056111 0.140603390241828 no 491 0.154533642524959 888 719745
SGTC_1072 oxiconazole 14.9 nM 1.01702887127695 0.140639389593284 no 492 0.154569847553654 809 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1009 4106-0057 9.87 µM 1.01229589561381 0.141761770253573 no 493 0.155698298363252 844 2928005
SGTC_2049 5262831 67.185 µM 1.0114697837805 0.141958295036779 no 494 0.15589581803489 779 763417
SGTC_2648 atorvastatin 78.68 µM 1.01034077734065 0.142227173963505 no 495 0.156166025483722 774 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.00967758318128 0.142385277774043 no 496 0.156324892899621 824 6728940
SGTC_1784 st039334 36.3 µM 1.00795782469029 0.142795817578561 no 497 0.156737354881683 776 3496984
SGTC_1927 st060202 13.8 µM 1.00713792666827 0.142991824578925 no 498 0.15693424879556 790 688887
SGTC_1948 st076329 66.6 µM 1.00629555742347 0.143193392866163 no 499 0.157136708447897 754 24208413
SGTC_1067 clotrimazole 1.36 µM 1.00470381709906 0.143574799908233 no 500 0.157519744799589 807 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1547 harmine 94.2 µM 1.00133106262287 0.144385231135396 no 501 0.158333390097277 870 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2466 5983409 37.09 µM 1.00080706923154 0.144511416428748 no 502 0.158460045609871 772 2879657
SGTC_1091 telmisartan 47.6 µM 0.999999412688148 0.144706057457739 no 503 0.158655396043773 822 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2066 5222451 176 µM 0.999980210790122 0.144710687163243 no 504 0.158660042388288 850 2281147
SGTC_839 0122-0028 230 µM 0.998533162050266 0.145059867308854 no 505 0.15901044608656 849 759448
SGTC_1415 3966-0071 78.1 µM 0.995615966967888 0.145765523934009 no 506 0.159718386880985 808 2893185
SGTC_2795 7780010 54.55 µM 0.994348753187986 0.146072775038348 no 507 0.160026554056382 758 953673
SGTC_3251 9135047 49.47 µM 0.990079648817402 0.147111070269865 no 508 0.161067594875843 789 17682963
SGTC_2331 7980721 200 µM 0.990013246332011 0.147127259101805 no 509 0.161083822256329 821 2981221
SGTC_1132 3456-3614 2.5 µM 0.987873342523557 0.147649604097566 no 510 0.161607341191759 902 3125502
SGTC_779 1360-0071 233 µM 0.987665124426826 0.147700495824954 no 511 0.161658340063502 866 7566
SGTC_1721 st082152 9.2685 µM 0.987393788815841 0.14776683207735 no 512 0.161724814052248 760 5296051
SGTC_145 3737-0113 38.366 µM 0.987114165347415 0.14783521541968 no 513 0.161793337103387 936 6849351
SGTC_3188 9110789 49.47 µM 0.986261729665321 0.148043813640519 no 514 0.162002347223671 814 849217
SGTC_491 tetrandrine 80.3 µM 0.981951150364051 0.14910166447457 no 515 0.163061957316469 791 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2283 7944793 200 µM 0.980428409788383 0.149476561089587 no 516 0.163437345922297 814 2970533
SGTC_620 0109-0052 432 µM 0.978396482148703 0.149977797948622 no 517 0.163939133705554 845 493037
SGTC_1759 st043059 70 µM 0.978387405474457 0.149980039498342 no 518 0.163941377445118 834 669426
SGTC_503 tyrphostin 8 294 µM 0.977221746892111 0.150268092889245 no 519 0.164229691998314 822 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2890 9046729 58.44 µM 0.975837550702492 0.150610629072313 no 520 0.164572486541157 760 903329
SGTC_1571 st070080 73.4 µM 0.973874124965067 0.151097393942657 no 521 0.165059521331357 824 4315245
SGTC_1820 st053765 18.6 µM 0.971310511347662 0.151734529015373 no 522 0.165696837998529 788 3690829
SGTC_1822 st052468 42 µM 0.971210054352515 0.151759531898508 no 523 0.16572184405177 801 2873678
SGTC_545 4218-0007 221 µM 0.968854646959579 0.152346557229338 no 524 0.166308858277759 793 2840508
SGTC_738 1315-0003 72.4 µM 0.968795408816123 0.152361340232481 no 525 0.166323638887202 840 6251474
SGTC_335 4077-0256 27.6 µM 0.965441895764323 0.153199769149771 no 526 0.167161762786051 933 3121989
SGTC_440 fluspirilene 35.1 µM 0.964177011070546 0.15351680203429 no 527 0.167478593963045 840 3396 An atypical antipsychotic.
SGTC_648 0375-0473 33.3 µM 0.96342021961271 0.153706693158387 no 528 0.16766834166591 866 1713139
SGTC_506 n9-isopropylolomoucine 153 µM 0.963275830748789 0.153742940298714 no 529 0.167704559507599 852 6610355
SGTC_538 2922-0838 53.3 µM 0.961354215953143 0.154225878023801 no 530 0.16818704820927 934 777039
SGTC_3095 9117207 49.47 µM 0.960944075915755 0.154329083664807 no 531 0.168290143764813 789 17015229
SGTC_532 1548-0774 215 µM 0.960638286528296 0.154406060726803 no 532 0.16836703548557 885 5932993
SGTC_797 k781-0471 270 µM 0.959453144428148 0.154704639059779 no 533 0.168665256698511 854 23738129
SGTC_1602 st001878 87.6 µM 0.957583862575009 0.15517635078368 no 534 0.169136319864085 851 595405 YLR310C CDC25
SGTC_3101 9120531 49.47 µM 0.956516862736606 0.155446032534935 no 535 0.169405584551613 854 24824904
SGTC_2602 kawain 100 µM 0.954810596543413 0.155877929654735 no 536 0.169836743849984 909 5369129
SGTC_654 1124-0271 80.9 µM 0.950101000326946 0.157074143542333 no 537 0.171030467491764 862 5403748
SGTC_3339 9145883 14.936 µM 0.949189265210311 0.157306415421966 no 538 0.171262180142573 810 2030670
SGTC_3195 9113082 49.47 µM 0.947999699731227 0.157609806154967 no 539 0.171564803531203 836 17018038
SGTC_444 curcumin 90.4 µM 0.947181426712418 0.15781872425961 no 540 0.171773168994069 842 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2147 5545932 89.7195 µM 0.947137487014522 0.157829947905749 no 541 0.171784362392066 843 797404
SGTC_3083 9117465 49.47 µM 0.947029343493251 0.157857573555843 no 542 0.171811913347489 854 16420915
SGTC_2266 7929956 200 µM 0.946446837915049 0.158006431307893 no 543 0.17196036268238 855 2967153
SGTC_2399 5884133 200 µM 0.943792250547518 0.158685970605444 no 544 0.1726379107261 823 722445
SGTC_2829 7992743 58.44 µM 0.943457485065366 0.158771802000114 no 545 0.172723475848721 879 16462845
SGTC_1453 4237-0541 195 µM 0.943067593819485 0.15887180558873 no 546 0.1728231650342 881 739892
SGTC_190 3970-0790 3.722 µM 0.941996910235153 0.159146638567212 no 547 0.17309711090245 843 2832352
SGTC_3045 9092950 49.47 µM 0.941557787070805 0.159259446771609 no 548 0.173209545208965 904 44120432
SGTC_3132 9126706 49.47 µM 0.940517709660399 0.159526845504821 no 549 0.173476034980506 819 850858
SGTC_919 tnp00227 403.569 nM 0.939702659418342 0.159736596132513 no 550 0.173685050319603 893 1269246 A methoxyflavone. YNL221C POP1
SGTC_588 3970-1144 52.9 µM 0.934211309760484 0.161154478849204 no 551 0.175097451445901 859 1888707
SGTC_2123 5259487 200 µM 0.933487656537574 0.16134193876069 no 552 0.175284120323482 901 2173474
SGTC_939 1165-0479 45.3 µM 0.928226016815773 0.162709223218551 no 553 0.176645170785237 880 1377347
SGTC_627 1391-0720 175 µM 0.927891265359656 0.162796465663843 no 554 0.176731987865534 849 997839
SGTC_3155 9099265 49.47 µM 0.924374139637772 0.163714932465199 no 555 0.177645777038676 814 25236499
SGTC_2475 5812728 15.03 µM 0.922543766808513 0.164194246625249 no 556 0.178122506033314 968 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1266 0828-0227 32.9 µM 0.920337687685615 0.164773154073007 no 557 0.178698160154094 859 3913820
SGTC_1234 0326-0494 15.5 µM 0.916113783460805 0.165885252938219 no 558 0.179803609578882 897 1547813
SGTC_662 k832-1615 104 µM 0.912091602640985 0.166948739325898 no 559 0.180860249235434 868 5878478
SGTC_1245 0418-0076 17.2 µM 0.909248319424751 0.167703165817494 no 560 0.181609531858209 880 6790114
SGTC_1367 1812-0510 76.9 µM 0.908503019386703 0.167901283644851 no 561 0.181806259618294 888 1142582 YDR527W RBA50
SGTC_2704 st078022 71.1 µM 0.907529657264228 0.168160252376012 no 562 0.182063386793736 922 54697681
SGTC_2128 5255449 168.493 µM 0.907445680242687 0.168182606993782 no 563 0.182085581143483 945 736008
SGTC_2771 fluoxetine 41.05 µM 0.90690190316397 0.168327406299172 no 564 0.182229337328009 864 3386 A selective serotonin reuptake inhibitor.
SGTC_3232 9132874 49.47 µM 0.906265781264095 0.168496897314661 no 565 0.182397596342283 886 3784940
SGTC_439 amiodarone 34.4 µM 0.905628478054989 0.168666813078284 no 566 0.182566265120678 896 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2368 9071271 200 µM 0.904423613188121 0.168988351142421 no 567 0.182885410929782 872 27209959
SGTC_2382 9035899 200 µM 0.903821657586467 0.169149140314875 no 568 0.183044987885253 900 6462679
SGTC_56 0957-0365 83.25 µM 0.898299001310761 0.170628887143613 no 569 0.184513082416974 897 6752360
SGTC_2594 a-mangostin 100 µM 0.89774047397543 0.170778999670738 no 570 0.184661963115051 909 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3111 9122088 49.47 µM 0.89773956827543 0.1707792431597 no 571 0.18466220459852 806 16876704
SGTC_2657 nystatin 74.44 µM 0.896105536945737 0.171218898948009 no 572 0.18509820007193 938 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2237 6667747 47.222 µM 0.894070478529014 0.171767466894303 no 573 0.185642091673489 858 729940 YDL015C TSC13
SGTC_615 k087-0205 167 µM 0.894054664334952 0.171771734140566 no 574 0.185646322068708 865 9642773
SGTC_2853 9015042 58.44 µM 0.890261921946081 0.172797109453863 no 575 0.186662631109963 881 6457456
SGTC_167 3672-0051 66.205 µM 0.889662171752728 0.172959609591548 no 576 0.186823655922037 866 3237971
SGTC_1698 5-fluorocytosine 1.055 µM 0.889292986146954 0.173059687490065 no 577 0.186922819996701 948 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1181 1222-0449 220 µM 0.887336627245961 0.173590627784787 no 578 0.187448845741615 933 658318
SGTC_176 1486-1328 72.834 µM 0.885701748795778 0.174035114973787 no 579 0.187889132855543 951 22310231
SGTC_2647 atorvastatin 60.16 µM 0.884806693682329 0.17427876683158 no 580 0.188130449328326 911 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2264 7948757 110.76 µM 0.882955142685507 0.174783483536629 no 581 0.188630254137361 896 2971411
SGTC_1984 st072354 53.1 µM 0.880649176847159 0.175413365700749 no 582 0.189253866386432 925 5762938
SGTC_997 3996-0078 137 µM 0.880579841056701 0.175432327258036 no 583 0.189272636797296 954 735687
SGTC_3133 9127736 49.47 µM 0.877828218969785 0.17618587397459 no 584 0.190018474036614 935 27243420
SGTC_932 2857-0803 154 µM 0.872012226807692 0.177785344709926 no 585 0.191600853700937 1000 674898
SGTC_908 3448-7491 47.7 µM 0.872010175376372 0.177785910490411 no 586 0.191601413262041 984 1203031
SGTC_216 k038-0035 28.382 µM 0.871039600393164 0.178053720434369 no 587 0.19186626555998 904 4444231 YPR107C YTH1
SGTC_2964 9083345 53.42 µM 0.870921353471624 0.178086365581135 no 588 0.191898548307809 887 17741579
SGTC_79 0052-0007 94.094 µM 0.870449063293336 0.178216791232944 no 589 0.192027522030003 954 2801472
SGTC_696 1560-0013 611 µM 0.869436530417012 0.1784966108413 no 590 0.192304204765461 941 1650269
SGTC_137 0438-0332 85.389 µM 0.867249493376209 0.179101955635848 no 591 0.192902661709102 1038 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2177 5811945 192 µM 0.867220830678124 0.179109897680343 no 592 0.192910512463374 966 5343475
SGTC_2390 9097792 176.6 µM 0.865992725305794 0.179450397101827 no 593 0.193247075583685 906 4497149
SGTC_140 0062-0056 502.533 µM 0.865892730780383 0.179478139074603 no 594 0.19327449492087 1020 3758964
SGTC_2959 9079155 11 µM 0.865590162505375 0.179562098497826 no 595 0.193357476138962 897 16189457
SGTC_1996 st072960 66.8 µM 0.865587944790909 0.179562713980714 no 596 0.193358084441094 979 1719405
SGTC_1101 ebselen 5.29 µM 0.865459273116898 0.17959842653493 no 597 0.193393380097381 1030 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3209 9113616 49.47 µM 0.861980789440303 0.180565563358951 no 598 0.194349044631012 995 16649353
SGTC_407 eburnamonine 100 µM 0.861125518318077 0.180803857202535 no 599 0.194584458017725 901 3195
SGTC_969 1313-0238 134 µM 0.860464839422852 0.180988069061858 no 600 0.194766428634468 979 5212874
SGTC_1087 pterostilbene 9.05 µM 0.858845409559004 0.181440099068459 no 601 0.195212905417881 981 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3055 9094636 49.47 µM 0.85472085268997 0.182594571757511 no 602 0.196352851767702 944 25236176
SGTC_1353 1498-1206 8.11 µM 0.852998445232085 0.183078032284408 no 603 0.196830083201423 993 6756808
SGTC_3283 9109332 35.8195 µM 0.852283998920032 0.183278803489238 no 604 0.197028242409375 875 17027281
SGTC_84 0443-0269 128.823 µM 0.851897298353136 0.183387529977256 no 605 0.19713554822984 986 6150058
SGTC_2702 st077768 96.8 µM 0.851387486672567 0.183530932384428 no 606 0.197277070272744 858 6484119
SGTC_378 3970-0959 8.33 µM 0.85011776984365 0.183888388438411 no 607 0.197629806524757 957 6615653
SGTC_113 0099-0221 2.5 µM 0.849329416680281 0.184110546983305 no 608 0.197849008273623 931 89219
SGTC_1199 1638-0010 4.46 µM 0.84860353045828 0.184315249968067 no 609 0.198050970909135 948 3111136
SGTC_2046 4110841 106 µM 0.848157780365069 0.184441023534809 no 610 0.198175053209999 995 44119630 YMR134W ERG29
SGTC_2798 7813637 45.45 µM 0.847739378689657 0.184559128990907 no 611 0.19829156529308 943 956368
SGTC_422 cantharidin 155 µM 0.846104051068 0.185021196497692 no 612 0.19874735051008 947 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1798 st045719 60.953 µM 0.844863625090214 0.185372162080746 no 613 0.199093492864141 939 3980186
SGTC_2213 7173844 200 µM 0.844273815109765 0.185539187546518 no 614 0.199258207371878 995 892728
SGTC_475 α-linolenic acid 10 µM 0.843178000436966 0.18584975392257 no 615 0.199564450127879 1064 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2777 climbazole 1.536 µM 0.842701224399809 0.185984978282489 no 616 0.199697781123549 1002 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1119 parthenolide 318.541 nM 0.842613956212129 0.186009736097733 no 617 0.199722191579268 1031 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2093 5331342 194.4 µM 0.841394996808228 0.186355766075324 no 618 0.200063343708877 993 33839
SGTC_3237 9133362 49.47 µM 0.84134346973297 0.186370402013712 no 619 0.200077772387197 965 43845137
SGTC_2661 dactinomycin 12.96 µM 0.839236335331176 0.186969530012489 no 620 0.200668350584396 1014 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2463 5473429 200 µM 0.839083263158028 0.187013099871987 no 621 0.200711293702804 953 5399405
SGTC_249 wiskostatin 11.211 µM 0.838285194295929 0.187240360773449 no 622 0.200935274591132 1007 2775510 A n-wasp and actin depolymerizer.
SGTC_2440 5628896 157.78 µM 0.838174175830625 0.187271988307349 no 623 0.200966444198765 978 5522048
SGTC_1002 4049-0206 172 µM 0.837042209427928 0.1875946574624 no 624 0.201284421273264 1034 4662749
SGTC_3282 9108498 15.4605 µM 0.836692189393234 0.187694500822887 no 625 0.201382805304369 929 16459645
SGTC_1024 4507-0395 26 µM 0.835924452069547 0.187913613152033 no 626 0.201598702706335 938 4201836
SGTC_493 zm226600 134 µM 0.835527475781993 0.18802697215474 no 627 0.201710391801057 991 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1251 0490-5699 265 µM 0.835476892034931 0.18804141968411 no 628 0.201724626176393 1060 3883818
SGTC_2352 9027995 87.8 µM 0.834459932953127 0.188332024863926 no 629 0.202010928260016 928 2997347
SGTC_973 1325-0077 65.9 µM 0.834245635618811 0.188393297573027 no 630 0.202071289890444 1044 2835149
SGTC_2308 7584454 197.62 µM 0.833515442725477 0.188602169415408 no 631 0.202277046058993 1021 893577
SGTC_1005 4092-0690 4.4 µM 0.83278055947613 0.188812527026999 no 632 0.202484250367933 942 1529343
SGTC_2065 5221596 34.26 µM 0.829547619716764 0.189739660121039 no 633 0.203397301245499 965 788581
SGTC_892 0929-0076 29 µM 0.829068979610383 0.189877160703573 no 634 0.203532687834351 1018 5751038
SGTC_1193 1488-0126 41.5 µM 0.826864656070859 0.190511194701025 no 635 0.20415688908499 1057 1384710
SGTC_1334 1486-0610 236 µM 0.826372676035784 0.190652881143377 no 636 0.204296359205805 994 3742339
SGTC_3177 9107506 49.47 µM 0.825726543214792 0.190839060618147 no 637 0.204479615845004 979 8897194
SGTC_2055 5235184 200 µM 0.823728817926586 0.191415398991471 no 638 0.205046830604426 982 2836034
SGTC_732 3970-1727 52.7 µM 0.821854419082943 0.19195712674302 no 639 0.205579878705516 1014 1275699
SGTC_1351 1496-0003 46.5 µM 0.821458510566929 0.192071669817833 no 640 0.205692573694414 1030 3891978
SGTC_2441 5730946 39.09 µM 0.82119175615204 0.192148869990052 no 641 0.205768525759534 998 1774275
SGTC_1707 st032323 6.317 µM 0.821160283397334 0.192157979627553 no 642 0.205777487985955 980 3132057 YMR211W DML1
SGTC_1460 k062-0059 9.15 µM 0.820841057261153 0.192250393028208 no 643 0.205868404363645 1014 1373085
SGTC_2292 7671323 168.05 µM 0.820482110682878 0.192354337640366 no 644 0.205970661677113 993 937504
SGTC_2998 9066762 71.4286 µM 0.819958408060927 0.192506054339616 no 645 0.206119909002831 1009 4945196
SGTC_1615 st002656 86.5 µM 0.819765032993378 0.192562093602768 no 646 0.206175034177596 993 1584458
SGTC_2393 9031399 185.94 µM 0.819537217379844 0.192628126380069 no 647 0.206239988485785 1034 1526623 YDL150W RPC53
SGTC_2886 9058944 51.95 µM 0.818904972545779 0.192811456200024 no 648 0.206420316334314 876 4949929
SGTC_236 1509-0011 5.31 µM 0.818502141674813 0.192928319230493 no 649 0.206535259811659 1143 3107280
SGTC_1336 1486-0901 104 µM 0.81802291519462 0.193067401298483 no 650 0.206672051327609 999 5006114
SGTC_926 2268-1401 59.4 µM 0.817085801645191 0.193339549111291 no 651 0.206939698167285 1057 2931578
SGTC_2605 digitonin 300 nM 0.816846639119043 0.193409041947151 no 652 0.207008037665892 1106 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2286 7945697 125 µM 0.816810494627001 0.193419545684044 no 653 0.207018366935616 1025 1245733
SGTC_1093 fluphenazine 7.97 µM 0.815908137925608 0.193681887011933 no 654 0.207276338686653 1064 6602611 An atypical antipsychotic.
SGTC_3042 9091578 49.47 µM 0.815222047549436 0.193881498552684 no 655 0.207472609933055 986 25236497
SGTC_3013 9080133 71.4286 µM 0.812951684111451 0.194542932885363 no 656 0.208122880078094 1063 17050193
SGTC_2344 7990960 76.95 µM 0.812660616236635 0.194627830092995 no 657 0.208206333698515 954 140813
SGTC_3027 9089541 49.47 µM 0.812575195230531 0.194652749538718 no 658 0.208230828957304 1026 9943819
SGTC_2589 lobaric acid 100 µM 0.812123560023773 0.194784535096657 no 659 0.208360367763439 1008 73157 A novel microtubule depolymerizer.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.809980165166095 0.195410709776919 no 660 0.208975787831731 1075 551469
SGTC_1578 josamycin 24.2 µM 0.806663306484733 0.196382108752255 no 661 0.20993024496049 951 5282165 A P450 substrate.
SGTC_1384 3089-0840 101 µM 0.805912187950397 0.1966024924773 no 662 0.210146741587471 986 1069836
SGTC_2360 9040895 200 µM 0.805733400928357 0.196654971978173 no 663 0.210198293100191 968 4914414
SGTC_772 k072-0172 35.3 µM 0.804983934004241 0.196875055945053 no 664 0.210414475469304 982 5861980
SGTC_2291 7917025 104.35 µM 0.80492428150142 0.196892579546434 no 665 0.21043168773093 990 2964612
SGTC_473 2-arachidonoylglycerol 10 µM 0.8035605569416 0.197293446666469 no 666 0.210825405128695 963 5282280 An endocannabinoid.
SGTC_1886 st057356 49.9 µM 0.80308350448583 0.197433792810002 no 667 0.210963235643383 970 24207747
SGTC_345 1362-0200 395 µM 0.802899425902762 0.197487963829685 no 668 0.211016433950144 996 1419823
SGTC_883 0850-0245 24.6 µM 0.801377211408959 0.197936268542011 no 669 0.211456651901668 1057 6823229 YPR165W RHO1
SGTC_2336 9001819 198.65 µM 0.800879128037623 0.198083091569955 no 670 0.211600812186011 1052 2989602
SGTC_1359 1582-0056 520 nM 0.799913015177292 0.198368065883738 no 671 0.211880598228506 1074 3661189
SGTC_693 4161-2696 114 µM 0.798805586291832 0.198695028337314 no 672 0.212201575427872 1005 805759
SGTC_2793 7325131 81.82 µM 0.798757779464258 0.198709150360681 no 673 0.212215438156484 1007 4176441
SGTC_1794 st048918 76.9 µM 0.798464328166957 0.198795848435811 no 674 0.212300542948611 995 672303
SGTC_1945 st075991 56.6 µM 0.797800891765672 0.198991939988926 no 675 0.212493021865369 992 1084980
SGTC_1376 2910-0861 41.3 µM 0.797417552620307 0.199105296453509 no 676 0.21260428425956 1055 1112859
SGTC_1431 4049-0260 9.09 µM 0.797009584434506 0.199225978645355 no 677 0.21272273248189 1049 3854841
SGTC_837 0091-0265 12.5 µM 0.795223574005715 0.199754821704162 no 678 0.213241730578052 1036 759367
SGTC_3137 9097352 49.47 µM 0.793401298861161 0.200295272316891 no 679 0.213772027124245 1122 44120435
SGTC_1558 st069300 45.6 µM 0.791866150201148 0.200751248030484 no 680 0.214219363049007 993 24208000
SGTC_18 0111-0177 500 nM 0.791864926262415 0.20075161181783 no 681 0.214219719916791 1151 721752
SGTC_2801 7907800 81.82 µM 0.788894581823652 0.201635642956281 no 682 0.215086811365807 1063 6620925
SGTC_2617 dihydrotanshinone i 20.83 µM 0.788382063094112 0.201788413857457 no 683 0.215236629709272 1096 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.78733412311287 0.202100998081025 no 684 0.215543149663091 1078 6710655
SGTC_683 panaxydol 45 µM 0.784823535473595 0.202851045034686 no 685 0.216278519481872 1071 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_194 1486-1323 56.904 µM 0.784699986698069 0.202887998547563 no 686 0.21631474529655 1084 5178754
SGTC_426 0988-0037 14.6 µM 0.784399042955439 0.202978027826346 no 687 0.216402999898435 1091 5383008
SGTC_1636 st007707 68.9 µM 0.78332318243339 0.20330007354819 no 688 0.216718676549056 1087 403051
SGTC_26 0302-0163 425.158 µM 0.782894409658382 0.203428506377928 no 689 0.216844560302229 1081 3100915
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.782806357828127 0.203454887049811 no 690 0.21687041674292 1061 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.782700924470757 0.203486477979786 no 691 0.216901379617881 1060 97141
SGTC_2187 6125751 200 µM 0.782412007343657 0.203573061028884 no 692 0.216986239720057 1042 874498
SGTC_1534 6-azauridine 81.6 µM 0.78214655687006 0.203652630925605 no 693 0.217064224159402 1124 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_124 0136-0217 7.121 µM 0.780546909052495 0.204132524568106 no 694 0.217534513835366 1213 3976905
SGTC_2380 9035439 200 µM 0.779257252698997 0.204519910878659 no 695 0.21791409516492 1123 6462575
SGTC_614 0462-0418 107 µM 0.774206507285728 0.206041257529927 no 696 0.219404340375734 982 5188303
SGTC_2173 5763948 167 µM 0.773863615662908 0.206144783405065 no 697 0.219505723916226 1120 2867177
SGTC_1809 st050081 57.6 µM 0.773567956075688 0.206234073734604 no 698 0.219593163856081 1096 5036894
SGTC_217 ketoconazole 989 nM 0.772890472843269 0.206438762702829 no 699 0.21979360177216 1046 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2000 st075254 36.4 µM 0.772661780678572 0.206507884954393 no 700 0.219861285570457 1039 17234175
SGTC_2545 solidagenone 89.61 µM 0.771825563499988 0.206760748456129 no 701 0.220108874461396 904 6708572 An anti ulcer agent
SGTC_2001 4023502 57.655 µM 0.770936770717076 0.207029711141974 no 702 0.220372205283185 1056 108941 YCR052W RSC6
SGTC_1712 st032288 53.4 µM 0.767271762905038 0.208140985003556 no 703 0.221459976685755 1121 2883011
SGTC_2973 9094665 17.96 µM 0.766943672131955 0.208240637399505 no 704 0.221557503236583 1117 25237061 YIL048W NEO1
SGTC_1997 st073024 93.8 µM 0.766706239876465 0.208312771255103 no 705 0.221628096417481 1095 686268
SGTC_755 1995-0008 37.3 µM 0.766110977575775 0.208493681586468 no 706 0.221805135857522 1115 689533
SGTC_864 0469-0573 172 µM 0.765813303326298 0.208584184588429 no 707 0.221893698686405 1049 689425
SGTC_1665 st014639 11.4 µM 0.765688736756495 0.208622063895743 no 708 0.221930765217084 1163 981133 YIL048W NEO1
SGTC_2211 7117706 200 µM 0.765353809636277 0.208723931612243 no 709 0.222030445013391 1058 822771
SGTC_2385 9074692 200 µM 0.763926472710772 0.20915838312256 no 710 0.222455530313946 1089 17046906
SGTC_2742 clothiapine 36.27 µM 0.763246962233001 0.209365398828788 no 711 0.222658063098914 1043 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2787 5284540 71.43 µM 0.762815860338318 0.209496798313636 no 712 0.222786610468716 1070 736958
SGTC_2810 7959871 45.46 µM 0.761726117229779 0.209829167314104 no 713 0.223111742120625 1115 2974535
SGTC_2644 guaiazulene 100 µM 0.760463683598219 0.210214593786595 no 714 0.223488734625335 1109 3515 A coloring agent.
SGTC_2299 7976368 114.88 µM 0.759963677757925 0.210367362623069 no 715 0.223638148303306 1089 2979718
SGTC_2513 baicalein 25.65 µM 0.759920653130172 0.210380511159115 no 716 0.223651007742503 1106 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2744 captopril 92.04 µM 0.75940311866697 0.210538710017946 no 717 0.223805724254907 1058 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2634 4'-methoxyflavone 100 µM 0.756204151825583 0.211518111862902 no 718 0.224763401948929 1065 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1773 st048542 73.5835 µM 0.755197677218906 0.211826806883093 no 719 0.225065191078796 1051 3237138
SGTC_2124 5246320 200 µM 0.755193633840512 0.211828047555807 no 720 0.225066403939523 1068 579342
SGTC_3060 1327-0027 12.5 µM 0.755044139398803 0.211873921506713 no 721 0.225111249222644 1061 16000455 YPR107C YTH1
SGTC_2430 5571206 200 µM 0.754019194691321 0.212188593118644 no 722 0.225418848034763 1175 1731771
SGTC_2820 7989630 71.43 µM 0.753284631457491 0.212414281738973 no 723 0.225639446011897 999 2984098
SGTC_2474 5321570 43.32 µM 0.75038495550062 0.213306552269684 no 724 0.226511444601836 1110 2841384
SGTC_813 k007-0158 173 µM 0.74938962208497 0.213613333254536 no 725 0.226811202081894 1145 6523916
SGTC_1143 3454-2408 5.08 µM 0.748511230682177 0.213884283862531 no 726 0.227075926767965 1079 X1143
SGTC_2523 spermine 47.74 µM 0.748289809431777 0.213952615529842 no 727 0.227142684945141 1094 1103 A DNA binding polyamine.
SGTC_142 0335-0849 62.6745 µM 0.747854046422778 0.214087131209804 no 728 0.227274099149041 1135 3889043 YPR107C YTH1
SGTC_642 0335-0876 158 µM 0.747667392234107 0.214144764542802 no 729 0.227330402050297 1123 6812350
SGTC_1133 3473-0247 50 µM 0.747272358695952 0.214266769068696 no 730 0.227449587004625 1075 711311
SGTC_3356 9151811 4.48 µM 0.745266131698922 0.214887008060985 no 731 0.228055425608575 1084 1859254 YPR165W RHO1
SGTC_583 1488-1091 88.9 µM 0.744266315974598 0.215196496990006 no 732 0.228357687572167 1241 4303273
SGTC_394 menadione 8.33 µM 0.743798544760885 0.215341382476889 no 733 0.228499180346473 1101 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1495 4469-0029 237 µM 0.740599034495004 0.216333901746769 no 734 0.229468296804819 1170 793680
SGTC_2756 carbadox 75.1 µM 0.740515234144443 0.216359932968631 no 735 0.229493710449523 1112 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2747 doxorubicin 7.63 µM 0.739462843730548 0.216686995327083 no 736 0.229812997006524 1002 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1861 st057647 17.4 µM 0.739417146557779 0.216701203589465 no 737 0.22982686678336 1140 688668
SGTC_1256 0570-0116 285 µM 0.738368842895257 0.217027292324742 no 738 0.230145171322387 1128 410638
SGTC_2665 lovastatin 100 µM 0.738289180820225 0.217052083855715 no 739 0.230169369812225 1135 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2167 5876490 200 µM 0.737917514478215 0.217167771281863 no 740 0.230282287565884 1132 686534
SGTC_1946 st076057 65.1 µM 0.737823438252088 0.217197059744456 no 741 0.230310874232777 1035 953009
SGTC_2678 equilin 100 µM 0.737228232993731 0.217382416047959 no 742 0.230491783496296 1155 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1804 st050076 49.1 µM 0.736588394553384 0.217581773655412 no 743 0.230686347316771 1130 3895976
SGTC_2873 9040596 71.43 µM 0.735131098265719 0.218036224243358 no 744 0.231129828238437 1149 6463863
SGTC_1762 st045503 25.4615 µM 0.734836844234546 0.218128052250898 no 745 0.231219432617478 1172 4645554
SGTC_2240 6690706 185.951 µM 0.734700747103671 0.218170531690673 no 746 0.231260882610089 1043 805876
SGTC_2357 9067248 200 µM 0.733151091640474 0.218654555385411 no 747 0.231733140728176 1119 9150235
SGTC_1473 k844-0725 134 µM 0.732898827687871 0.218733406669657 no 748 0.231810069091327 1224 54682906
SGTC_1515 3460-0031 42.1 µM 0.727889721603468 0.220302510865585 no 749 0.233340547778268 1088 2876596
SGTC_2591 skatole 100 µM 0.727730203150676 0.22035258587606 no 750 0.233389378878156 1157 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1361 1608-0041 5.61 µM 0.727697134241609 0.220362967472539 no 751 0.233399502499223 1143 X1361
SGTC_1172 0370-0043 85 µM 0.726901512399505 0.220612828135579 no 752 0.233643145319562 1168 376585
SGTC_1847 st056231 15 µM 0.72649608499648 0.22074021278064 no 753 0.233767353336783 1182 5393180
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.725541836700042 0.221040202275976 no 754 0.234059844246847 1158 5355888
SGTC_2363 9053361 176 µM 0.721291612700319 0.222379186625876 no 755 0.235365058122313 1170 6469797 YMR079W SEC14
SGTC_2673 kobusone 100 µM 0.720099132091885 0.222755693459062 no 756 0.235731980928946 1211 6710676 An epoxy ketone and protein crosslinker.
SGTC_3212 9128307 49.47 µM 0.718330961863289 0.223314633273913 no 757 0.2362766218863 1091 27243542
SGTC_2983 9022671 12.99 µM 0.718228533996766 0.223347036389856 no 758 0.236308193467222 1137 6405161
SGTC_2310 7668677 200 µM 0.718216126042206 0.223350961835272 no 759 0.236312018157813 1173 2197143
SGTC_1114 scopoletin 1.73284 µM 0.717720029094977 0.223507941822109 no 760 0.236464965508249 1182 5280460 A coumarin with genotoxic properties.
SGTC_3329 9141233 27.5565 µM 0.717603899389447 0.223544697814868 no 761 0.236500776319448 1153 4909101 YNL103W MET4
SGTC_1634 st006576 41 µM 0.716453477723659 0.22390900126663 no 762 0.236855691981636 1154 3915356
SGTC_3150 9097574 49.47 µM 0.716130796390851 0.224011245156054 no 763 0.236955294704516 1140 17217476
SGTC_275 trichlorophene 5.69 µM 0.715382974011109 0.22424829996504 no 764 0.237186215086787 1189 62616
SGTC_2763 lisinopril 49.32 µM 0.714756000474625 0.224447156199903 no 765 0.237379913737818 1135 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3236 9132701 49.47 µM 0.712007295169818 0.225320138975666 no 766 0.238230129288201 1148 24282524
SGTC_3211 9128781 49.47 µM 0.710619792982258 0.225761535852744 no 767 0.238659937190664 1104 17194361
SGTC_2783 7738165 71.43 µM 0.710584774010892 0.225772682530509 no 768 0.238670790538815 1115 17201110
SGTC_330 1488-0319 80.1 µM 0.708001313518884 0.226595866411476 no 769 0.239472220892112 1143 6846614
SGTC_1227 3909-8010 46.6 µM 0.707937448051304 0.226616237693492 no 770 0.239492051566422 1146 15982272
SGTC_2506 ethyl hematommate 54.16 µM 0.7077892756819 0.226663504479304 no 771 0.239538063576497 1154 3940691 An allergen.
SGTC_2874 9043904 71.43 µM 0.706251688488649 0.227154321038388 no 772 0.240015815756234 1100 4463428
SGTC_417 st075190 100 µM 0.705708634625868 0.227327813500101 no 773 0.240184675081971 1184 222757
SGTC_3311 9131146 2.8755 µM 0.705212927419356 0.227486245018505 no 774 0.240338868757852 1140 4900406 YPR165W RHO1
SGTC_2153 5569715 200 µM 0.705052803273407 0.22753743510983 no 775 0.240388688170182 1175 2054701
SGTC_784 4579-0127 173 µM 0.704854485512107 0.227600844310114 no 776 0.240450398556032 1224 1948547
SGTC_507 nimesulide 162 µM 0.704609784101373 0.227679097713448 no 777 0.240526553995687 1189 4495 A COX2 inhibitor.
SGTC_3165 9101544 49.47 µM 0.703763115805942 0.22794997177184 no 778 0.240790153564976 1168 5002184
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.702480649131586 0.228360615600585 no 779 0.241189732700953 1131 279621
SGTC_1202 1988-0068 29.6 µM 0.701672330604024 0.228619651373159 no 780 0.241441766185103 1141 2850480
SGTC_1392 3455-1037 33.9 µM 0.697988061683587 0.229802409239729 no 781 0.242592330049516 1198 981132
SGTC_2730 imipramine 71.33 µM 0.697978175863336 0.229805587478749 no 782 0.242595421290682 1212 3696 A tricyclic antidepressant.
SGTC_3017 9080681 49.47 µM 0.697125662807832 0.23007975848396 no 783 0.242862077609704 1171 16451914
SGTC_1140 3229-1848 2.98 µM 0.695498154300214 0.230603678446512 no 784 0.24337158373483 1202 2849525
SGTC_2607 solasodine 47.35 µM 0.695328493050909 0.230658333349757 no 785 0.24342473093464 1211 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1681 tripelennamine 100 µM 0.695017859108262 0.230758420139551 no 786 0.243522054755505 1198 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2426 5582046 32.21 µM 0.694525619460551 0.23091707026465 no 787 0.24367631996541 1199 2251934
SGTC_2061 5245884 80.95 µM 0.692305489833925 0.231633380098908 no 788 0.244372751617577 1201 573863
SGTC_605 1315-0399 119 µM 0.692020765383744 0.231725334027778 no 789 0.244462144265297 1242 24020461
SGTC_2738 aclarubicin 5.55 µM 0.69170482846433 0.231827392063018 no 790 0.244561357058656 1110 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_173 1273-0061 2.693 µM 0.691612687853371 0.231857161231703 no 791 0.244590295803174 1170 2847414 YPL266W DIM1
SGTC_45 0kpi-0036 14.9 µM 0.691148517124245 0.232007159801702 no 792 0.244736106666996 1193 2795021
SGTC_121 0557-0495 61.343 µM 0.690550578232555 0.2322004656772 no 793 0.244924007336813 1328 3104427
SGTC_75 0159-0059 199.013 µM 0.690445648535841 0.232234397327139 no 794 0.24495698921336 1238 5377270
SGTC_647 0140-0236 81 µM 0.690115165355014 0.232341285383128 no 795 0.245060883479705 1226 990837
SGTC_338 4055-0136 114 µM 0.689494537035835 0.232542088913597 no 796 0.245256054943735 1179 2900563
SGTC_1755 st041960 45.185 µM 0.687922138536311 0.233051268193596 no 797 0.245750907209321 1209 2257073
SGTC_1401 3807-4679 7.6 µM 0.6859807479868 0.233680788865138 no 798 0.246362624366711 1191 3291456
SGTC_2745 rifampicin 24.3 µM 0.684523955132635 0.234153790986489 no 799 0.246822183971715 1129 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.684461981019269 0.23417392494252 no 800 0.246841744485405 1211 442882
SGTC_2094 5332512 191.667 µM 0.683995113892258 0.234325630079346 no 801 0.24698912559321 1242 755774
SGTC_1219 1469-0211 33.1 µM 0.682961085596809 0.234661823753563 no 802 0.247315716293681 1186 6822282
SGTC_2778 tioconazole 65.09 nM 0.682679808785886 0.234753321422542 no 803 0.2474045955573 1185 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2034 5197015 53.07 µM 0.682678849241512 0.234753633590357 no 804 0.24740489878818 1209 780676
SGTC_1998 st075797 76.8 µM 0.679208774576514 0.235884050127226 no 805 0.248502794184676 1225 24208315
SGTC_1902 st060212 70.5 µM 0.677908056852237 0.236308545684498 no 806 0.248914995621292 1247 688944
SGTC_3007 9078383 71.4286 µM 0.677846319849268 0.236328704306411 no 807 0.248934569309002 1218 6496995
SGTC_3289 9119912 71.43 µM 0.676944022676587 0.23662343413126 no 808 0.24922073565324 1242 17014829
SGTC_1866 st057638 64 µM 0.674490759476595 0.237425798874406 no 809 0.249999679274407 1224 688802
SGTC_3310 9130229 44.1445 µM 0.674189527941517 0.237524422579504 no 810 0.250095413257781 1235 7761258
SGTC_744 1594-0068 283 µM 0.673283004016069 0.237821355625004 no 811 0.2503836316771 1257 668392
SGTC_465 cgp-37157 41 µM 0.670384921068825 0.238771990611629 no 812 0.251306222277486 1160 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2646 retinol 96.75 µM 0.670004908101733 0.238896797207397 no 813 0.251427330703581 1249 445354 A vitamin A analog and teratogen.
SGTC_2662 daunorubicin 22.37 µM 0.668801688823992 0.239292202357454 no 814 0.251810994646446 1193 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1063 disulfiram 1.84 µM 0.668351727035671 0.23944016180827 no 815 0.251954550864117 1245 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_363 0455-0021 3.06 µM 0.668195343867037 0.239491596466442 no 816 0.252004453604165 1259 4597466
SGTC_754 3474-0146 171 µM 0.667776479072573 0.23962939143861 no 817 0.252138141380704 1188 24762078
SGTC_1421 4029-0249 71.4 µM 0.667536994974157 0.239708194545515 no 818 0.252214593582004 1318 2894095
SGTC_3125 9127534 49.47 µM 0.667070577064126 0.23986171162561 no 819 0.25236352654996 1135 1639235
SGTC_1920 st075728 45.7 µM 0.666444317883848 0.240067923280518 no 820 0.252563571686194 1274 3400306
SGTC_3197 9113331 49.47 µM 0.666092350890759 0.240183859714017 no 821 0.252676036692566 1288 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2759 disulfiram 3.38 µM 0.665642418359652 0.240332110006121 no 822 0.252819843303278 1202 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3306 9127676 59.7925 µM 0.66206559709377 0.24151242443692 no 823 0.253964591375215 1245 41905287
SGTC_152 4469-0003 551.229 µM 0.661686260123943 0.241637786133348 no 824 0.254086156059675 1235 697280
SGTC_2420 aureobasidin a 50 nM 0.661494420983148 0.241701197778756 no 825 0.254147645643335 1326 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1978 st071761 42 µM 0.661055753566649 0.241846231439755 no 826 0.254288279622719 1206 5147680
SGTC_2856 9022925 19.48 µM 0.660594114317791 0.24199891110416 no 827 0.254436322272222 1245 4944862
SGTC_2328 6201408 200 µM 0.660178004386819 0.24213657747433 no 828 0.254569802861891 1219 2890418
SGTC_2944 9067346 25.62 µM 0.658586644946032 0.242663456453428 no 829 0.255080620577803 1218 6473075
SGTC_1216 1165-0504 9.65 µM 0.658470801002166 0.242701835139736 no 830 0.255117826777311 1249 6304004
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.657327091331721 0.243080918387093 no 831 0.255485310225742 1232 61125 An anti-inflammatory.
SGTC_2372 9071633 200 µM 0.657325766389225 0.243081357725679 no 832 0.25548573610113 1275 21321366
SGTC_3262 9137218 49.47 µM 0.65694384862868 0.243208015996423 no 833 0.25560851113461 1128 17650664
SGTC_38 0929-0051 58.268 µM 0.656465044812672 0.243366855710425 no 834 0.255762475632059 1257 1379719
SGTC_1625 st003711 30.1 µM 0.65495887690819 0.243866881374967 no 835 0.256247115569216 1323 24207034 YER133W GLC7
SGTC_1846 st056244 14.8 µM 0.654808341706214 0.24391688731216 no 836 0.256295579612742 1273 5393182
SGTC_449 xestospongin c 11.1929 µM 0.65268529765477 0.244622725253787 no 837 0.256979591378067 1240 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.652122937009859 0.244809874618197 no 838 0.257160934194636 1394 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_612 0302-0167 22.4 µM 0.651840381045606 0.244903936185155 no 839 0.25725207431054 1294 235821
SGTC_716 1683-5115 658 µM 0.65004825709867 0.245500978513595 no 840 0.257830525341279 1289 723597
SGTC_442 cape 100 µM 0.649461407938542 0.245696655902475 no 841 0.258020091598684 1260 5281787
SGTC_2844 9010103 25.97 µM 0.649423340519359 0.245709351891107 no 842 0.258032390778085 1261 2480525
SGTC_1638 st008370 60.6 µM 0.648779498544015 0.245924135072588 no 843 0.258240455344393 1262 24207134
SGTC_727 3032-0951 202 µM 0.648500303576928 0.246017304737548 no 844 0.258330707271396 1267 3652836
SGTC_2338 7999974 200 µM 0.647437642153582 0.246372096768705 no 845 0.258674370214924 1315 315925
SGTC_1961 st076550 68.7 µM 0.647436106366377 0.246372609722183 no 846 0.258674867057178 1253 1579337
SGTC_2691 st077356 60.2 µM 0.64676210270003 0.246597782428723 no 847 0.25889296154098 1314 2839272
SGTC_2992 9074591 71.4286 µM 0.646626867130786 0.246642975515343 no 848 0.25893673259812 1283 17741321
SGTC_1074 carmofur 3.8 µM 0.646403895878833 0.24671749783909 no 849 0.259008909006912 1297 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_285 1486-1325 46 µM 0.646094348551961 0.246820975942131 no 850 0.259109127576317 1290 22310230
SGTC_940 3232-1287 54.8 µM 0.644382217291651 0.247393741081156 no 851 0.259663806482628 1249 1585493 YIL048W NEO1
SGTC_617 3770-0098 35 µM 0.644319677957457 0.2474146760189 no 852 0.25968407893829 1257 5962639
SGTC_917 harmaline 728.087 nM 0.643555209780342 0.247670656970371 no 853 0.259931951347675 1286 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2740 felodipine 17.08 µM 0.643330391226511 0.24774596401104 no 854 0.260004870096848 1238 3333 L-type calcium channel blocker
SGTC_136 0097-0015 404.482 µM 0.643168438656304 0.247800220528774 no 855 0.26005740512117 1282 4861337
SGTC_3104 9120930 49.47 µM 0.638704795153964 0.249298101033759 no 856 0.261507496342211 1279 17014836
SGTC_2067 5224629 34.075 µM 0.638681661326188 0.249305876652948 no 857 0.261515022562026 1269 2835000
SGTC_1696 st025591 34.7925 µM 0.633905192140668 0.250914075974575 no 858 0.263071348457231 1303 2787147
SGTC_788 1182-0090 188 µM 0.633597051638858 0.251018012647482 no 859 0.263171912732284 1399 5715185
SGTC_2405 ticlatone 3.52 µM 0.633439979393072 0.251071002329918 no 860 0.263223182152392 1193 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3230 9131665 49.47 µM 0.632784529873909 0.25129218775902 no 861 0.263437180262055 1238 15943720
SGTC_55 0767-0285 6.563 µM 0.63277119923652 0.25129668733246 no 862 0.26344153351123 1256 3116166
SGTC_1805 st050013 60.3 µM 0.632024647573372 0.25154874356283 no 863 0.263685385809695 1263 4037144
SGTC_1324 1418-0026 34.4 µM 0.631869020886461 0.251601304202198 no 864 0.263736233930812 1322 1372513
SGTC_1190 1486-1332 13 µM 0.631660027999062 0.251671897621732 no 865 0.263804526330248 1277 4150046
SGTC_3199 9111318 49.47 µM 0.627780340527195 0.252984272097079 no 866 0.265073923267328 1290 8548020
SGTC_1070 indatraline 8.81 µM 0.627588641713148 0.253049210923272 no 867 0.265136725650365 1276 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.627368815249854 0.253123688908754 no 868 0.265208752223345 1361 94937 An inhibitor of serotonin biosynthesis.
SGTC_723 4182-0001 115 µM 0.626990606630852 0.253251854309028 no 869 0.265332696268346 1266 744821 YLR208W SEC13
SGTC_1936 st074407 74.3 µM 0.626538903387823 0.253404969891659 no 870 0.265480764005839 1315 809813
SGTC_3214 9129694 49.47 µM 0.624867248802896 0.253972039999495 no 871 0.266029094617272 1295 17158655
SGTC_1360 1598-0022 39.8 µM 0.624397123838862 0.254131638889383 no 872 0.266183406739248 1361 761525
SGTC_2091 4-phenylthiadiazole 200 µM 0.623340265871654 0.254490614937439 no 873 0.266530471352344 1305 270010
SGTC_2567 aureobasidin a 60 nM 0.619214254453372 0.255894609587804 no 874 0.26788761128722 1383 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_289 k017-0060 526 µM 0.615185295396013 0.257269469869072 no 875 0.269216178809894 1306 5512909
SGTC_1022 4477-0945 21.3 µM 0.615033286014736 0.257321417303652 no 876 0.269266369220482 1311 4648966
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.613799156569385 0.257743368364053 no 877 0.269674027339174 1366 5377381
SGTC_2027 5150920 200 µM 0.613602571711249 0.257810614224385 no 878 0.269738991859295 1300 786715
SGTC_2471 5466956 24.79 µM 0.613158016058225 0.257962717123299 no 879 0.269885931077543 1320 724419
SGTC_1171 0368-0077 21.4 µM 0.611244889807455 0.258617816281127 no 880 0.270518734626924 1284 3239779
SGTC_2225 6654152 15.4 µM 0.610295929082754 0.258943081926785 no 881 0.27083289657417 1296 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2695 st077686 51.995 µM 0.610038569185556 0.259031331032164 no 882 0.270918129252825 1295 2876092
SGTC_780 0109-0199 192 µM 0.609948265985612 0.259062299824385 no 883 0.270948039118403 1396 610414
SGTC_233 rapamycin 362 pM 0.607961021690414 0.259744294403887 no 884 0.271606663023347 1340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_976 1348-1067 47.6 µM 0.60747552032665 0.259911052435006 no 885 0.271767691755374 1358 5310671 YGL099W LSG1
SGTC_3295 9122362 53.5725 µM 0.606294749919252 0.260316848997718 no 886 0.272159522133989 1323 4730473
SGTC_1800 st050079 29.0735 µM 0.605944698694798 0.260437214155031 no 887 0.272275738119375 1293 3645560
SGTC_667 1498-1044 59 µM 0.604866530879081 0.260808122310531 no 888 0.272633841554451 1362 6739982
SGTC_2220 6782180 200 µM 0.604506883245108 0.260931907660674 no 889 0.272753347152292 1283 833803
SGTC_3327 9140648 26.9345 µM 0.604364440669662 0.260980942621886 no 890 0.272800685900952 1334 8029710
SGTC_1382 3002-2117 298 µM 0.60339013685165 0.261316467585373 no 891 0.273124591053819 1385 1497314
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.603263278497103 0.261360170610602 no 892 0.273166778852724 1341 616764
SGTC_2436 5633522 8.09 µM 0.601378524823839 0.262009914961399 no 893 0.273793949427188 1337 5724242
SGTC_1787 fluconazole 80 µM 0.59902635246954 0.262821955802611 no 894 0.274577655796969 1251 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_988 1497-1057 103 µM 0.597727080406052 0.263271054891194 no 895 0.27501102650905 1362 3533044
SGTC_1277 0873-0036 22 µM 0.595259600811886 0.264125027662381 no 896 0.275834977995171 1420 5965735
SGTC_643 k048-0106 28.4 µM 0.59366096898067 0.264679052242707 no 897 0.276369446775533 1379 6763920
SGTC_2597 laccaic acid a 100 µM 0.593233049263965 0.264827453044696 no 898 0.276512598830349 1341 5491415 A textile dye.
SGTC_1048 3161-0300 24.5 µM 0.593154395341381 0.264854734503401 no 899 0.276538914894915 1335 2165101
SGTC_3149 9097855 49.47 µM 0.592914963953979 0.264937791124799 no 900 0.276619031512478 1403 25236625 YMR079W SEC14
SGTC_391 gliotoxin 8.33 µM 0.591907733434878 0.265287335344252 no 901 0.27695618747481 1414 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.591895956511833 0.265291423732708 no 902 0.276960130820458 1299 2333 A French combination drug.
SGTC_182 3448-4371 550.524 µM 0.591177609208879 0.265540860266938 no 903 0.277200711796364 1399 3491403
SGTC_468 gf-109203x 121 µM 0.590463418080387 0.265788971508151 no 904 0.277440002136462 1298 2396 A protein kinase C inhibitor.
SGTC_1878 temozolomide 1 mM 0.589427132245525 0.266149187844094 no 905 0.277787390032254 1361 5394 DNA alkylating agent.
SGTC_1430 4049-0248 69.1 µM 0.58937095474699 0.266168722386745 no 906 0.277806228146014 1428 22774488
SGTC_1096 rimcazole 32.2 µM 0.587289619563111 0.266892974178618 no 907 0.278504605771689 1304 18528119 A dopamine reuptake inhibitor.
SGTC_1208 2323-2347 50.3 µM 0.587189096326554 0.266927978899169 no 908 0.278538357288034 1363 5412760
SGTC_2625 euphol 100 µM 0.586474481901275 0.26717689245089 no 909 0.278778352460972 1395 6708538 A triterpene alcohol.
SGTC_282 k297-0036 65.7 µM 0.584947758563179 0.267709070949741 no 910 0.279291422186727 1380 5061378
SGTC_927 2425-1185 123 µM 0.584868304201494 0.267736781417946 no 911 0.279318136127461 1326 730375
SGTC_2325 6158266 200 µM 0.584037555539938 0.268026599486785 no 912 0.279597522628165 1367 3623240
SGTC_1818 st052136 56.3 µM 0.582501028188035 0.268563054027418 no 913 0.280114624578627 1282 674169
SGTC_3303 9125618 40.5795 µM 0.582426201766162 0.268589192278711 no 914 0.280139818445617 1444 22695467
SGTC_3136 9095672 49.47 µM 0.579696657406284 0.269543545662001 no 915 0.281059598933828 1245 17217380
SGTC_1967 st070177 51.4 µM 0.577706901935208 0.270240309739042 no 916 0.281731009292903 1440 5729214
SGTC_1739 st037196 92.5 µM 0.576413507795009 0.270693707469795 no 917 0.282167858179811 1414 612214
SGTC_621 3584-0052 32.1 µM 0.575318490825341 0.271077861022305 no 918 0.282537959108383 1384 2273927
SGTC_660 4031-1742 102 µM 0.573272703410279 0.271796291352251 no 919 0.283230032267916 1319 6738706
SGTC_1321 1326-2144 215 µM 0.572673659615179 0.272006840033352 no 920 0.283432837695079 1397 3513030
SGTC_3024 9090631 49.47 µM 0.572374464904889 0.272112029740294 no 921 0.283534155699566 1343 25236383
SGTC_1643 st009866 20.2 µM 0.572047224935623 0.272227102640558 no 922 0.283644990697581 1378 3156273 YOR207C RET1
SGTC_573 3702-0553 84.7 µM 0.571258048919665 0.272504713338896 no 923 0.283912367113772 1356 1222756
SGTC_529 4076-0302 30.3 µM 0.571161632563045 0.272538639629268 no 924 0.283945041680101 1359 5816522
SGTC_819 1013-0258 27.7 µM 0.571017338591571 0.272589416665786 no 925 0.283993944866365 1365 5753198
SGTC_845 0330-0138 4.51 µM 0.570234484551355 0.272864984765315 no 926 0.284259334948512 1391 9039800
SGTC_2669 eugenol 100 µM 0.570093121596767 0.272914759876727 no 927 0.284307270086924 1392 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2010 4012422 159 µM 0.569709998469087 0.273049683457217 no 928 0.284437203743779 1424 952393
SGTC_672 1441-0018 53.7 µM 0.568124904080698 0.273608253597731 no 929 0.284975079231752 1340 251141
SGTC_62 0180-0423 3.232 µM 0.567359473169649 0.273878185474029 no 930 0.285234989074323 1343 30102 YGL099W LSG1
SGTC_179 1273-0063 6.77 µM 0.566469770896126 0.274192107449218 no 931 0.285537238392209 1348 3108139
SGTC_2685 mycophenolic acid 18.85 µM 0.566163304559073 0.274300281970714 no 932 0.285641386309767 1401 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_734 2023-0417 80 µM 0.565230677790896 0.274629604159578 no 933 0.285958436466959 1413 3935732
SGTC_3328 9140624 29.0385 µM 0.562382407333564 0.275636569755153 no 934 0.286927751392333 1455 4904392
SGTC_1233 0325-0408 14.2 µM 0.561108270292616 0.27608760973323 no 935 0.287361865276447 1446 12874
SGTC_192 3455-0609 60.9 µM 0.56060506834614 0.27626584118987 no 936 0.28753339780704 1418 3769639
SGTC_758 0868-0029 16 µM 0.559452580630083 0.276674258817262 no 937 0.287926442529489 1411 762687
SGTC_376 3970-0862 59.1 µM 0.559425404600187 0.276683893005402 no 938 0.287935713710793 1433 3135186
SGTC_3168 9103419 49.47 µM 0.559137482238725 0.276785974603595 no 939 0.288033947914714 1375 16649256
SGTC_854 0422-0053 192 µM 0.558888226927852 0.276874361866854 no 940 0.288119002352434 1376 3596728
SGTC_3115 9123671 49.47 µM 0.557039558514062 0.277530340645313 no 941 0.288750200855851 1457 3286988
SGTC_2248 tofa 1.1 µM 0.556326541494912 0.277783549357982 no 942 0.288993823072494 1413 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1038 k292-0204 154 µM 0.556178398208366 0.277836172590049 no 943 0.28904445250204 1338 4454212
SGTC_1950 st077106 7.18 µM 0.554191208697331 0.278542529136747 no 944 0.289723997112577 1377 13831864
SGTC_3081 9117243 49.47 µM 0.553760399898273 0.278695777594547 no 945 0.289871416460953 1503 45595589
SGTC_1192 1488-0095 21.4 µM 0.552974647956432 0.278975393043162 no 946 0.290140385099553 1406 915875
SGTC_628 1636-0253 16 µM 0.552566037251764 0.279120853997275 no 947 0.290280301739536 1442 4456143
SGTC_690 glyoxal 20.3 µM 0.55234974786599 0.279197865582137 no 948 0.290354376426231 1311 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2443 5493264 126.67 µM 0.551326485770244 0.279562346274027 no 949 0.29070494268141 1477 5340055
SGTC_2762 leflunomide 42.06 µM 0.551215274596579 0.279601973034818 no 950 0.290743055189865 1426 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1719 st032227 49.2 µM 0.550598168237103 0.279821909876273 no 951 0.290954582420149 1386 3125804
SGTC_1606 st000094 49.2 µM 0.55055015395838 0.279839025693868 no 952 0.290971043420258 1447 1242210
SGTC_1525 8-methoxypsoralen 92.5 µM 0.55045356710558 0.279873457884713 no 953 0.291004158142025 1526 4114 Related to psoralen; DNA damaging agent.
SGTC_1965 Pectolinarigenin 58.4 µM 0.55000006765206 0.280035153107837 no 954 0.291159663587489 1389 5320438 An anti-inflammatory.
SGTC_1913 st060213 96.1 µM 0.547823235611252 0.280811932290641 no 955 0.291906641214911 1463 688959
SGTC_1290 0986-0249 10.2 µM 0.546133759707411 0.28141552083968 no 956 0.292486997551747 1371 53329
SGTC_1995 st072814 61.1 µM 0.546101644320289 0.281427000565237 no 957 0.292498034785675 1368 5769371
SGTC_502 l-744,832 89.3 µM 0.545600522726926 0.281606157000094 no 958 0.292670282480955 1425 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2114 5491910 81.25 µM 0.543916719222454 0.282208537685918 no 959 0.29324939159381 1496 2849228
SGTC_1620 st003704 16.5 µM 0.543333420537621 0.282417357323012 no 960 0.293450128821445 1420 2834414
SGTC_23 0213-0011 39.996 µM 0.542415278797303 0.282746200510543 no 961 0.293766228291332 1481 627608
SGTC_1839 st053978 48 µM 0.541065978673417 0.283229801682504 no 962 0.294231053420728 1444 3788398
SGTC_3050 9093513 49.47 µM 0.540428134782063 0.283458548638465 no 963 0.294450904704326 1403 25236664
SGTC_1673 st016611 27.3 µM 0.538447544580036 0.284169402222448 no 964 0.295134055022529 1506 5226799
SGTC_594 1487-1584 10.8 µM 0.536999106380267 0.284689800218174 no 965 0.295634115661288 1373 5013332
SGTC_1289 0976-0073 69.1 µM 0.536322009255553 0.284933225069154 no 966 0.29586801103677 1465 3391136
SGTC_3151 9099821 49.47 µM 0.534472764663762 0.285598556886977 no 967 0.296507243825784 1392 17174189
SGTC_1475 4092-1048 11.7 µM 0.534461556280824 0.285602591756448 no 968 0.29651112018307 1417 2881759
SGTC_1565 sinapyl alcohol 95.1 µM 0.533190770857791 0.286060233486968 no 969 0.296950764778939 1373 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2986 9022445 71.43 µM 0.532735404459647 0.286224307116616 no 970 0.297108377201827 1500 6459286
SGTC_691 1548-0686 185 µM 0.532552648469046 0.286290168718603 no 971 0.297171643863257 1397 46495133
SGTC_103 0844-0104 51.839 µM 0.531490378543951 0.286673131936867 no 972 0.29753950345601 1465 5375804
SGTC_2841 9004761 38.96 µM 0.530790996874535 0.286925401386561 no 973 0.2977818098103 1334 2991039
SGTC_251 melphalan 456.522 µM 0.530466400157569 0.287042520298364 no 974 0.297894299502971 1528 460612 A DNA alkylator.
SGTC_1226 3909-7979 35.4 µM 0.529270773283544 0.287474113913593 no 975 0.298308813595123 1503 6615510
SGTC_867 0518-0118 155 µM 0.529091287323474 0.28753893067182 no 976 0.298371062576538 1466 6848158
SGTC_1751 st044839 27.194 µM 0.528148552357012 0.287879488667869 no 977 0.298698117173395 1465 5291326
SGTC_1903 st060211 78.3 µM 0.527409009063045 0.288146778004006 no 978 0.298954794319679 1494 688960
SGTC_1777 st045864 34.765 µM 0.527141999106162 0.288243310803285 no 979 0.299047491465757 1445 4691462
SGTC_1372 2752-0194 270 µM 0.524486190293032 0.289204301596717 no 980 0.299970211205733 1392 823334
SGTC_3093 9117344 49.47 µM 0.523352129023851 0.289615114246138 no 981 0.300364615415719 1440 24824913
SGTC_191 3914-0123 66.505 µM 0.522409446771646 0.289956808388794 no 982 0.300692639998272 1370 3144412
SGTC_2204 7233102 200 µM 0.522394501362919 0.289962227174672 no 983 0.300697841844985 1452 2172480
SGTC_2275 7947463 200 µM 0.521894577975358 0.290143512721036 no 984 0.300871866826506 1426 1225414
SGTC_2995 9067767 71.4286 µM 0.519755165327737 0.290919920118012 no 985 0.301617116027902 1463 11673567
SGTC_2103 5378138 10 µM 0.51717608509927 0.291857174545665 no 986 0.302516622344437 1499 244142
SGTC_3021 9087658 49.47 µM 0.516622483338769 0.292058540220078 no 987 0.302709858801826 1454 25237042
SGTC_58 0957-0393 9 µM 0.515424542317657 0.292494497429704 no 988 0.303128193086228 1427 6997992
SGTC_2277 7947813 106.88 µM 0.514468515982588 0.292842633398414 no 989 0.303462233483201 1561 1246798
SGTC_1196 1588-0294 184 µM 0.512423456587643 0.293587984687661 no 990 0.304177338965924 1427 6144269
SGTC_611 3453-1652 23.7 µM 0.512247015689247 0.293652332248092 no 991 0.30423907104622 1520 1560575
SGTC_344 k064-0035 6.43 µM 0.510244016701067 0.294383278329916 no 992 0.30494025914827 1433 5088750
SGTC_2088 5278280 127.392 µM 0.508573808342914 0.29499342203623 no 993 0.305525495814826 1496 791502
SGTC_3094 9117742 49.47 µM 0.506546566899022 0.295734775205365 no 994 0.306236503985049 1409 17149698
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.504984043224875 0.296306766701827 no 995 0.30678502174161 1447 229346 A bile salt which induces apoptosis.
SGTC_2929 9013348 24.6 µM 0.502767224940058 0.297119144428971 no 996 0.307563969692631 1476 2995952
SGTC_1079 idarubicin 2.36 µM 0.502665968168144 0.29715627540798 no 997 0.307599570170644 1472 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2619 obliquin 87.91 µM 0.502393846809543 0.297256073144138 no 998 0.307695253247613 1531 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1326 1431-2094 10.8 µM 0.501620928485452 0.297539616568072 no 999 0.307967097451295 1445 616278
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.499902023521465 0.298170635365814 no 1000 0.308572033691779 1497 756377
SGTC_3003 9075612 71.4286 µM 0.499003847007135 0.298500602844613 no 1001 0.30888833695184 1483 6501993
SGTC_3253 9135987 49.47 µM 0.497951388002869 0.298887461070946 no 1002 0.309259152987368 1485 4182430
SGTC_785 1270-0111 65.3 µM 0.497533290737386 0.299041206605623 no 1003 0.30940651641627 1446 6741994
SGTC_252 miconazole 1.30953 nM 0.497303554126916 0.299125702178922 no 1004 0.309487502910469 1471 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1741 st038134 10.228 µM 0.496718095885199 0.299341078747068 no 1005 0.309693929827222 1605 1272587
SGTC_1425 4048-4433 7.33 µM 0.496304186271071 0.299493388964302 no 1006 0.309839906587292 1530 23734946
SGTC_1061 3448-9325 110 µM 0.496289012279314 0.299498973348392 no 1007 0.309845258688341 1470 723482
SGTC_355 1311-2252 105 µM 0.495482399757959 0.299795893549424 no 1008 0.310129821365476 1450 5338538
SGTC_1365 1672-3266 55.4 µM 0.495058610824426 0.299951946869908 no 1009 0.310279374322466 1535 6415873
SGTC_2751 anetholtrithion 17.25 µM 0.494795994054092 0.300048669630735 no 1010 0.310372066192772 1574 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1960 st011366 51.8 µM 0.494174189104955 0.300277739005959 no 1011 0.310591583298234 1485 3972846
SGTC_336 4111-0029 111 µM 0.49357359186646 0.300499070601309 no 1012 0.310803677453186 1447 3131175
SGTC_3242 9133940 49.47 µM 0.493569825935201 0.300500458651593 no 1013 0.310805007547866 1516 17248444
SGTC_2329 6138490 200 µM 0.492740120025066 0.300806342962409 no 1014 0.311098112822702 1513 720019
SGTC_454 lyso-paf C-16 6.67 µM 0.489047708254428 0.302169309591482 no 1015 0.312403960588825 1402 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_637 1181-0519 7.26 µM 0.488233659855521 0.30247016888257 no 1016 0.312692172614367 1483 6252091 YGR060W ERG25
SGTC_144 4161-2749 112.381 µM 0.48795893743388 0.302571732206572 no 1017 0.312789463341038 1419 797501 YMR168C CEP3
SGTC_284 0988-0104 32.6 µM 0.486746358779417 0.303020198171989 no 1018 0.313219044037587 1540 4666532
SGTC_492 tmb-8 126 µM 0.484527301343972 0.30384167429147 no 1019 0.314005846763238 1459 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1377 2944-0135 198 µM 0.484058127209419 0.304015485694989 no 1020 0.314172308542949 1555 1894137
SGTC_1778 st046819 58.9 µM 0.483937583835007 0.304060149645789 no 1021 0.314215083129157 1524 671715
SGTC_1660 st012960 28.1 µM 0.483813860036272 0.304105995054365 no 1022 0.314258988877831 1491 24207266
SGTC_568 1193-0097 7.48 µM 0.483596366897385 0.304186593820758 no 1023 0.314336176835149 1448 3646150
SGTC_443 clozapine 122 µM 0.482343350517423 0.304651122768309 no 1024 0.314781028327686 1502 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2320 7373003 200 µM 0.482102153569408 0.304740577560481 no 1025 0.314866690033441 1433 5415828
SGTC_1931 st074438 57.1 µM 0.481319029311014 0.305031102080793 no 1026 0.315144887251287 1467 2787313
SGTC_207 4185-0010 4.486 µM 0.479131221796381 0.305843388922169 no 1027 0.315922639801096 1552 3761753
SGTC_421 streptovitacin 30 mM 0.4791201186645 0.305847513722632 no 1028 0.315926588981176 1531 91467 include heat shock
SGTC_543 3844-1095 191 µM 0.478360463238773 0.306129783283984 no 1029 0.316196834333435 1585 4230703
SGTC_1709 st033179 39.1045 µM 0.477920592400853 0.306293281286615 no 1030 0.31635336209932 1496 573381
SGTC_2185 6113692 200 µM 0.477323669243291 0.30651521662531 no 1031 0.316565829463495 1520 874150
SGTC_881 0833-0569 170 µM 0.477310194342876 0.306520227397212 no 1032 0.316570626385516 1459 5418700
SGTC_2378 9074213 121.43 µM 0.477190748798866 0.306564645958069 no 1033 0.316613149084575 1484 657714
SGTC_2584 androsterone 48.74 µM 0.476132885758024 0.306958160524204 no 1034 0.316989854819906 1532 2754130 A steroid.
SGTC_2 0422-0095 29 µM 0.475978591230118 0.307015575163122 no 1035 0.317044815071611 1431 6790840
SGTC_2472 5377652 49.4 µM 0.474323996433147 0.307631564795149 no 1036 0.317634441063966 1485 1610903
SGTC_2870 9038528 12.99 µM 0.473969866461458 0.307763474529083 no 1037 0.317760697848281 1494 6463316
SGTC_3166 9102297 49.47 µM 0.473945852705533 0.307772420303508 no 1038 0.317769260160478 1462 25237072
SGTC_2416 tofa 880 nM 0.47306481693822 0.308100708957809 no 1039 0.318083468420427 1430 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1378 2093-0007 380 nM 0.472682340233217 0.308243274000423 no 1040 0.318219913815823 1540 3618014
SGTC_2121 5257820 149.641 µM 0.471628813058969 0.308636117126514 no 1041 0.318595878424743 1595 791256
SGTC_295 k015-0027 31 µM 0.471358537957945 0.308736933645632 no 1042 0.318692359671406 1517 3887424
SGTC_2915 7971052 15.16 µM 0.46838926460799 0.309845463343003 no 1043 0.319753121863158 1432 5741558
SGTC_2840 9008771 71.43 µM 0.46710619738928 0.310325011844109 no 1044 0.320211950223882 1657 2992978
SGTC_246 cycloheximide 667 µM 0.466846600960707 0.310422075709978 no 1045 0.320304816095664 1478 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1952 st077036 64.1 µM 0.466316337795692 0.310620383687305 no 1046 0.320494543009929 1508 2937007
SGTC_2138 5575593 77.673 µM 0.466102672041985 0.310700306030931 no 1047 0.32057100537879 1494 762213
SGTC_697 0508-1955 564 µM 0.465413409105231 0.310958187868716 no 1048 0.320817716720004 1623 6243113
SGTC_1168 k815-0004 80.5 µM 0.465413092061606 0.310958306509255 no 1049 0.32081783021924 1503 642433
SGTC_2709 st078560 56 µM 0.464095061080443 0.311451695113072 no 1050 0.321289820056999 1645 17250903
SGTC_2564 betulinic acid 100 µM 0.460095735397981 0.312950864218135 no 1051 0.32272375250209 1738 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1098 clofazimine 15.1 µM 0.459382596043938 0.313218514602273 no 1052 0.322979721989768 1580 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1364 1653-0028 37.6 µM 0.459273085375747 0.313259624087606 no 1053 0.32301903645034 1552 5718652
SGTC_2229 7354935 190 µM 0.458774897153847 0.313446669504485 no 1054 0.323197911570136 1558 318112
SGTC_2458 5808907 16.39 µM 0.458683553827526 0.313480969682503 no 1055 0.323230712945272 1572 2731747
SGTC_3032 9089427 49.47 µM 0.457065426820689 0.314088856971146 no 1056 0.323812009731939 1515 17173707
SGTC_1754 st042065 16.137 µM 0.456825608861783 0.314178993187391 no 1057 0.323898198683106 1483 1126236 YIL048W NEO1
SGTC_10 0279-0212 42.575 µM 0.456025139954782 0.314479931767351 no 1058 0.324185950129504 1525 39851 YBR002C RER2
SGTC_2948 9070189 9.45 µM 0.45577698979748 0.314573249579163 no 1059 0.324275176141396 1622 6473636 YDL196W YDL196W
SGTC_1727 st034309 9.9045 µM 0.455575010175263 0.31464921353116 no 1060 0.324347808313759 1667 870305
SGTC_2296 7971656 126.45 µM 0.454208955879664 0.315163188443981 no 1061 0.324839218817128 1535 666570
SGTC_733 4069-0007 56.1 µM 0.453334356513495 0.315492442584633 no 1062 0.325153998507274 1580 5717425 YNL287W SEC21
SGTC_354 2783-3500 4.88 µM 0.453216737915579 0.315536732797806 no 1063 0.325196340497651 1481 6740761
SGTC_2116 5511452 16.8835 µM 0.452680643559505 0.315738636924388 no 1064 0.325389359835904 1568 870744
SGTC_688 0527-0193 473 µM 0.452395823125855 0.31584592851646 no 1065 0.325491927730144 1581 4007154
SGTC_3089 9117425 49.47 µM 0.452327462724119 0.315871682125588 no 1066 0.32551654725136 1482 9401657
SGTC_1422 4031-0024 15.5 µM 0.450647497172206 0.316504860967678 no 1067 0.326121814121396 1535 782427
SGTC_2784 7567673 72.73 µM 0.449651384796006 0.316880549913045 no 1068 0.326480915325001 1540 3471247
SGTC_374 0880-0231 82.3 µM 0.448173768141672 0.31743818855832 no 1069 0.327013896360857 1550 6833587
SGTC_695 3505-6186 243 µM 0.447569727849987 0.317666267145623 no 1070 0.32723187733995 1608 1819379
SGTC_3118 9124250 49.47 µM 0.44710777888422 0.317840740414549 no 1071 0.327398621373079 1529 1504786
SGTC_1081 sertraline 6 µM 0.446801034072308 0.317956617056026 no 1072 0.327509362303509 1644 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3233 9132340 49.47 µM 0.446502867928426 0.318069270085348 no 1073 0.327617020713273 1503 17682950
SGTC_60 0986-0278 202 µM 0.446361646487464 0.318122632196783 no 1074 0.327668016333324 1386 3110598
SGTC_269 exalamide 29 µM 0.445908139419571 0.318294020473666 no 1075 0.327831801259799 1600 3316 A derivative of salicylamide.
SGTC_3078 9116413 49.47 µM 0.445583201292444 0.318416844218138 no 1076 0.327949173643604 1490 17177322
SGTC_859 0439-0102 54.6 µM 0.443320715133055 0.319272596762974 no 1077 0.32876688718569 1639 610143
SGTC_1158 4092-0494 91.8 µM 0.442609792373418 0.319541692186004 no 1078 0.329024000302044 1643 1148199
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.442462973714104 0.319597277199154 no 1079 0.329077108986081 1522 6312947
SGTC_2326 6164455 177.58 µM 0.441685521666016 0.319891685261159 no 1080 0.329358394043391 1559 2888790
SGTC_424 splitomicin 100 mM 0.43986355886078 0.320582076403228 no 1081 0.330017965239523 1527 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3321 9137793 26.8275 µM 0.439687811012436 0.320648704919001 no 1082 0.330081615946178 1559 4904192
SGTC_610 4215-0184 155 µM 0.438622849630762 0.321052570511448 no 1083 0.33046741881741 1595 5605015
SGTC_3071 9117417 49.47 µM 0.438043663925111 0.321272304205269 no 1084 0.33067731574617 1646 45595590 YGL055W OLE1
SGTC_456 gingerol 170 µM 0.437033904430392 0.321655540253978 no 1085 0.331043379971135 1623 442793 A herb.
SGTC_2534 helenine 20.12 µM 0.436989150877848 0.321672530056251 no 1086 0.331059608045975 1576 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_362 0310-0100 9.03 µM 0.436819883201704 0.321736792558697 no 1087 0.331120989026991 1572 790235
SGTC_1175 0741-0056 27.6 µM 0.435549228101746 0.322219367163299 no 1088 0.331581907326236 1680 765927
SGTC_1699 st031318 29.054 µM 0.43524478906136 0.322335032824328 no 1089 0.331692377665001 1627 5340658
SGTC_340 k038-0059 454 µM 0.434982017173549 0.322434881698557 no 1090 0.331787740214337 1614 23733424
SGTC_2125 5246583 200 µM 0.434155780817871 0.322748920981881 no 1091 0.332087660659654 1725 835267
SGTC_3018 9082602 49.47 µM 0.433371493127955 0.32304713324457 no 1092 0.332372453461292 1581 17332089
SGTC_875 0709-0210 25.7 µM 0.433228993289911 0.323101328642181 no 1093 0.332424208809763 1628 6251364
SGTC_3269 9137823 49.47 µM 0.432757863723827 0.323280534900723 no 1094 0.332595343849024 1547 17682936
SGTC_1482 3346-2049 8.48 µM 0.432184532493411 0.323498671514938 no 1095 0.33280365010896 1619 3826804
SGTC_1849 st056239 19.2 µM 0.431511404435729 0.323754855482821 no 1096 0.333048281049066 1471 5393181
SGTC_1154 4088-0362 150 µM 0.431508922703958 0.323755800152953 no 1097 0.333049183101679 1535 6618304
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.430597455628825 0.324102826449069 no 1098 0.333380545781349 1574 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1448 4255-0083 152 µM 0.430072270087683 0.324302851770567 no 1099 0.333571535390114 1720 5399660
SGTC_2033 5192550 145 µM 0.429884069321438 0.324374543391365 no 1100 0.333639987210855 1551 182073
SGTC_3215 9129942 49.47 µM 0.42980047688238 0.324406388481908 no 1101 0.333670392979571 1663 17682944
SGTC_1573 oleylamine 1.06 µM 0.427346146066663 0.325341953521164 no 1102 0.334563613186844 1556 5356789 An amine of the fatty acid oleic acid.
SGTC_1828 st055811 49 µM 0.427234239644519 0.325384637377183 no 1103 0.334604362379093 1675 5877589
SGTC_1434 4073-0095 163 µM 0.426105231485681 0.325815396846396 no 1104 0.335015584160243 1596 24133745
SGTC_848 0368-0089 85.6 µM 0.425582608338017 0.326014876221327 no 1105 0.33520600766818 1648 762535
SGTC_1137 ixabepilone 100 µM 0.424653017714205 0.326369813551959 no 1106 0.335544818915452 1538 154225 A novel microtubule stabilizer.
SGTC_3144 9087057 49.47 µM 0.424155739609858 0.32655974943018 no 1107 0.335726118595995 1748 17249618
SGTC_1689 st020265 53.493 µM 0.421377785194736 0.327621618079249 no 1108 0.336739619085587 1693 5758320 YPR016C TIF6
SGTC_2507 purpurin 79.67 µM 0.4210828310617 0.32773444593921 no 1109 0.336847299082862 1509 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2198 6589944 200 µM 0.421054750278599 0.327745188411432 no 1110 0.3368575513357 1638 5290268
SGTC_305 1682-2595 20.8 µM 0.418761068055336 0.3286231310319 no 1111 0.337695380084932 1626 226033
SGTC_416 estradiol valerate 100 µM 0.418420618438461 0.328753524243093 no 1112 0.337819807117757 1609 13791 A steroid.
SGTC_1717 st033143 58.0435 µM 0.418147575679745 0.328858115495166 no 1113 0.337919611199286 1723 674616
SGTC_3096 9117468 49.47 µM 0.417300445015472 0.329182701068797 no 1114 0.338229331525757 1565 41316311
SGTC_326 k292-0812 17.5 µM 0.417131238212858 0.329247549586399 no 1115 0.338291208528473 1696 3579357
SGTC_2002 4023503 131 µM 0.415450250465381 0.329892067019841 no 1116 0.338906163607006 1755 4736863 YCR052W RSC6
SGTC_1726 st035556 14.5795 µM 0.415125372609768 0.330016688684896 no 1117 0.339025063126539 1693 5919439
SGTC_2827 7993847 71.43 µM 0.413854398098976 0.330504409879736 no 1118 0.339490371193146 1633 2985692
SGTC_1690 st023502 41.2 µM 0.41293345190648 0.330857991921757 no 1119 0.339827685710326 1689 24207482
SGTC_1113 artemisinin 1.17947 µM 0.412667399360132 0.330960166507874 no 1120 0.339925156544891 1717 2240 An anti-malaria and mitochondrial poison.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.412205057637571 0.331137753766951 no 1121 0.340094565207007 1596 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_702 1488-0190 94 µM 0.412077684604685 0.331186684922191 no 1122 0.340141242193996 1733 949357
SGTC_2445 5742597 35.57 µM 0.410855983452985 0.331656155460666 no 1123 0.34058906986277 1568 1774255
SGTC_1011 4112-3381 17.4 µM 0.407516788416499 0.33294067618881 no 1124 0.341814233114303 1654 2877139
SGTC_3248 9135562 49.47 µM 0.407448424623 0.332966994911009 no 1125 0.341839333514221 1623 17650701
SGTC_1814 st052110 31.539 µM 0.40742664276596 0.332975380672425 no 1126 0.341847331071639 1716 674163
SGTC_2136 5328288 199.296 µM 0.406145424416779 0.33346878165769 no 1127 0.342317875654394 1591 262395
SGTC_1344 1488-0097 29.1 µM 0.406037136236232 0.333510496978979 no 1128 0.342357657171664 1637 747966
SGTC_66 0109-0187 42.4 µM 0.405392243361854 0.333758968501201 no 1129 0.342594605824823 1538 759417
SGTC_1506 4226-2149 212 µM 0.403298720951106 0.33456608629612 no 1130 0.343364241281523 1665 991114
SGTC_2077 5212015 200 µM 0.402457015906322 0.334890805553784 no 1131 0.343673858205242 1542 780900
SGTC_965 1291-5240 308 µM 0.401011721122496 0.33544867012152 no 1132 0.344205747154083 1716 2834598
SGTC_811 0416-0114 265 µM 0.399219881210591 0.336140800413307 no 1133 0.344865597645981 1624 6612453
SGTC_2101 5377231 179.231 µM 0.398552779449639 0.336398622556397 no 1134 0.345111380612934 1716 2844213
SGTC_1497 4476-2978 41.3 µM 0.398484380952031 0.33642506162612 no 1135 0.345136584640275 1637 1528379
SGTC_3076 9116187 49.47 µM 0.397287620728799 0.336887793610742 no 1136 0.34557768752744 1757 27241210
SGTC_452 diindolylmethane 8 µM 0.394431836124717 0.337992990654262 no 1137 0.346631121566257 1674 3071 Inhibits expression of several cancer promoting factors.
SGTC_2951 9072950 58.06 µM 0.392795515351684 0.338626882242171 no 1138 0.347235258618046 1656 16488155
SGTC_923 1900-2434 73.3 µM 0.392260485244378 0.33883424598882 no 1139 0.347432878492969 1585 5910570
SGTC_2262 9014885 67.46 µM 0.391428143714616 0.339156937003467 no 1140 0.34774039639639 1748 6457424
SGTC_255 tunicamycin 200.472 nM 0.389054848998879 0.340077688487129 no 1141 0.34861778631558 1756 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_722 3534-0461 190 µM 0.388975308210185 0.34010856396426 no 1142 0.348647206031418 1606 658262
SGTC_2142 5622915 118.518 µM 0.387532853316773 0.340668669880104 no 1143 0.349180883948636 1629 5322196
SGTC_2909 7941780 10.49 µM 0.386740036972594 0.340976670619126 no 1144 0.349474336431972 1787 1243215
SGTC_2236 dapsone 200 µM 0.385974268538436 0.341274264188524 no 1145 0.349757862860183 1685 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1253 0550-0034 176 µM 0.385559989842932 0.341435302692634 no 1146 0.349911284852828 1649 5969915
SGTC_2038 4100038 30.985 µM 0.385184570109101 0.341581260872468 no 1147 0.350050337171406 1675 3596803
SGTC_19 0279-0214 38.434 µM 0.383313928063478 0.342308894292967 no 1148 0.350743506694007 1682 3566274 YBR002C RER2
SGTC_1875 nocodazole 6 µM 0.382323353604771 0.342694440631802 no 1149 0.351110767196452 1743 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_484 loperamide 105 µM 0.382171248318675 0.342753656802669 no 1150 0.351167173330886 1660 3955 An opioid-receptor agonist.
SGTC_1934 st074720 32.6 µM 0.380989112813336 0.343214006064143 no 1151 0.351605663561328 1583 17250992
SGTC_938 3126-1755 342 µM 0.378115992115713 0.344333830909776 no 1152 0.352672214363713 1745 1777771
SGTC_3183 9108214 49.47 µM 0.376238323860151 0.345066407937607 no 1153 0.35336986330931 1669 4974831
SGTC_1257 0669-0121 16 µM 0.375963729790213 0.345173590275066 no 1154 0.353471930300159 1774 4307855
SGTC_781 4335-2806 94.4 µM 0.373191507673155 0.346256366468838 no 1155 0.354502958134618 1799 845254
SGTC_2388 9080168 200 µM 0.37125855464332 0.347012085343773 no 1156 0.355222482057857 1591 15943073
SGTC_3301 9125354 19.7965 µM 0.370563608785789 0.347283934500779 no 1157 0.355481295596361 1629 41905162
SGTC_3257 9139206 32.98 µM 0.369926521077971 0.347533219738834 no 1158 0.355718620020459 1732 4910041
SGTC_824 1304-0008 100 µM 0.369727475198824 0.347611117673883 no 1159 0.355792778973807 1680 768245
SGTC_1426 4048-4480 71.7 µM 0.3689352891501 0.347921208719067 no 1160 0.356087979502448 1744 14224343
SGTC_1030 k029-0042 36.7 µM 0.367842453365075 0.348349152191576 no 1161 0.356495355863432 1684 6080581
SGTC_2428 5615643 7.78 µM 0.367393887749385 0.348524861898549 no 1162 0.356662615091201 1722 2253075
SGTC_1926 methyl fluorone black 53.6 µM 0.367121511636844 0.34863157146621 no 1163 0.356764190984161 1620 72721 Reacts with homocysteine.
SGTC_1527 coumarin 137 µM 0.365781408545593 0.349156761776677 no 1164 0.35726409688854 1733 323 A hepatotoxic, DNA x-linker.
SGTC_1993 st073995 70.8 µM 0.36428573792492 0.349743260739168 no 1165 0.35782232439232 1690 3098394
SGTC_3091 9116372 49.47 µM 0.36330944936262 0.350126287461423 no 1166 0.358186867674572 1697 17169793
SGTC_203 k066-0004 30.888 µM 0.363239546648972 0.350153718207855 no 1167 0.358212974107506 1820 6795412
SGTC_2401 5128683 200 µM 0.358034818672354 0.352198309470307 no 1168 0.360158628433493 1595 708373
SGTC_2863 9028737 58.44 µM 0.357402064683699 0.352447169338997 no 1169 0.36039541564914 1804 6460917
SGTC_197 4544-0043 41.561 µM 0.356326071702293 0.35287049852375 no 1170 0.360798193294406 1691 896523
SGTC_792 4534-1957 155 µM 0.356181032393872 0.352927575456858 no 1171 0.360852497841715 1724 1717904
SGTC_536 3852-0578 10.6 µM 0.354925248888115 0.353421898863749 no 1172 0.361322796227025 1796 2869208
SGTC_2078 5212016 200 µM 0.35484114131502 0.353455015600786 no 1173 0.361354302511626 1800 1899708
SGTC_1313 1220-0047 237 µM 0.354463638600634 0.35360366817368 no 1174 0.361495724756781 1748 3528706
SGTC_1670 st016595 4.04 µM 0.354072433466585 0.353757740028533 no 1175 0.361642300249217 1715 597879
SGTC_1835 st008666 49.2 µM 0.353035931999601 0.354166070536006 no 1176 0.362030751427529 1649 690455
SGTC_1671 st016596 74.5 µM 0.352820861944903 0.354250818569737 no 1177 0.362111371370417 1686 2829167
SGTC_1000 4048-0884 8.67 µM 0.352296094025293 0.354457632871906 no 1178 0.362308108569535 1730 13040088
SGTC_2707 st078556 66.6 µM 0.352214649530781 0.354489734503001 no 1179 0.362338645637304 1822 17250899
SGTC_581 0958-0271 211 µM 0.351170959996478 0.354901199791172 no 1180 0.362730047516372 1647 4591145
SGTC_1521 st012942 49.4 µM 0.351077466899606 0.354938066879763 no 1181 0.36276511607499 1875 24207259
SGTC_1399 3562-5772 25 µM 0.350107059829549 0.35532080720037 no 1182 0.36312917640953 1699 23847490
SGTC_947 3447-0010 211 µM 0.349435760583159 0.355585661214293 no 1183 0.363381095115208 1683 748350
SGTC_1770 st043884 66.3 µM 0.346384352269603 0.356790439417203 no 1184 0.364526941595892 1693 670149
SGTC_675 1309-0189 238 µM 0.346207286571568 0.35686039373362 no 1185 0.36459346952908 1694 4246530
SGTC_1395 3486-0190 4.35 µM 0.346175460027057 0.356872968131548 no 1186 0.364605427976288 1852 6748079
SGTC_2614 arthonioic acid 13.39 µM 0.346025701936692 0.356932138370725 no 1187 0.364661699573692 1636 6710684
SGTC_3029 9088683 49.47 µM 0.344227571474097 0.357642857927053 no 1188 0.365337574421606 1724 25236615
SGTC_487 nimodipine 119 µM 0.344136198115361 0.357678986885817 no 1189 0.365371930702012 1796 4497 L-type voltage-gated calcium channels inhibitor
SGTC_606 k015-0008 38.6 µM 0.342563664361173 0.358300965152115 no 1190 0.365963370702404 1816 1970475
SGTC_1994 st072947 40.9 µM 0.33995393644779 0.359334010374872 no 1191 0.366945608739002 1767 5286565 YDL195W SEC31
SGTC_3322 9139058 2.11 µM 0.338885808625518 0.359757119635599 no 1192 0.367347877810151 1772 4908926 YPR165W RHO1
SGTC_472 calcifediol 10 µM 0.33859812913341 0.359871105312371 no 1193 0.367456246086093 1743 5283731 A vitamin D metabolite.
SGTC_3064 1327-0027 10 µM 0.338181374834204 0.360036255700441 no 1194 0.367613255299205 1711 16000455 YPR107C YTH1
SGTC_1472 k841-0093 193 µM 0.337967385280583 0.360121065118873 no 1195 0.367693882939373 1815 X1472
SGTC_47 0149-0135 24.25 µM 0.336000467319242 0.360900925965669 no 1196 0.368435257035243 1609 5239155
SGTC_3181 9108277 49.47 µM 0.33554868067491 0.361080136129273 no 1197 0.368605614543661 1685 17097298
SGTC_2235 salicylic acid 500 µM 0.335501844064129 0.361098716548412 no 1198 0.368623276942925 1766 338 A COX inhibitor and kinase inhibitor.
SGTC_535 2293-4129 48.2 µM 0.335368014194558 0.36115180962274 no 1199 0.368673746611498 1836 396118 YIL048W NEO1
SGTC_3127 9126946 49.47 µM 0.33526207661854 0.361193839144733 no 1200 0.368713699197124 1657 27243249
SGTC_3069 9117009 49.47 µM 0.334593751814597 0.361459027980428 no 1201 0.368965779420915 1779 41904981
SGTC_2529 gangaleoidin 93.61 µM 0.33408388045087 0.361661387845775 no 1202 0.36915813174296 1725 4565183
SGTC_1581 himbacine 57.9 µM 0.333981242955812 0.361702127721728 no 1203 0.369196856375804 1690 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2939 9044578 71.43 µM 0.333644085650716 0.361835966519277 no 1204 0.369324073544689 1681 2653634
SGTC_157 1348-1695 65.819 µM 0.332571830702623 0.362261723767106 no 1205 0.369728754950969 1712 5380510
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.332115617516871 0.362442922769044 no 1206 0.369900978871983 1891 688664
SGTC_3200 9114385 49.47 µM 0.330764521850883 0.362979732336068 no 1207 0.370411180647575 1670 17018030 YLR208W SEC13
SGTC_3331 9141060 1.957 µM 0.330594015598522 0.363047496061326 no 1208 0.370475583572046 1681 4906567 YPR165W RHO1
SGTC_3266 9136860 49.47 µM 0.33047507926372 0.363094767066786 no 1209 0.370520509867628 1718 4871271 YPR165W RHO1
SGTC_1788 fluconazole 20 µM 0.330020686736573 0.36327538365626 no 1210 0.370692165622951 1696 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2851 9015922 71.43 µM 0.329507457372792 0.363479423877517 no 1211 0.370886079113294 1815 2996893
SGTC_649 1123-0311 367 µM 0.327427556483122 0.364306708367989 no 1212 0.37167226351824 1833 693629 YIL048W NEO1
SGTC_708 3448-5400 146 µM 0.324519496280559 0.365464454659497 no 1213 0.372772382175002 1799 3462195
SGTC_1868 st057644 42.7 µM 0.324179200223759 0.365600012464891 no 1214 0.372901184157632 1712 688665
SGTC_193 1273-0060 1.558 µM 0.323646703886681 0.365812167425455 no 1215 0.373102762413947 1822 2847393 YHR072W ERG7
SGTC_531 3788-1495 174 µM 0.323592891968717 0.365833609229012 no 1216 0.373123135027907 1712 2896655
SGTC_3139 9095020 49.47 µM 0.322882440960783 0.366116733576429 no 1217 0.37339213738561 1689 25236292
SGTC_3348 9149464 3.537 µM 0.322208540914521 0.366385359255145 no 1218 0.373647357267002 1737 1951442
SGTC_918 glabranin 770.725 nM 0.322163993862983 0.366403118621461 no 1219 0.373664230110566 1775 124049 Also referred to as licorice root.
SGTC_2418 pentamidine 31.67 µM 0.321992795291318 0.366471372223787 no 1220 0.373729076312375 1680 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1374 2889-5571 141 µM 0.321138333765965 0.366812092828147 no 1221 0.374052780697914 1719 2853281
SGTC_1485 3909-9022 254 µM 0.32024723083657 0.367167536175576 no 1222 0.374390460950273 1804 714516
SGTC_561 1550-0330 72.9 µM 0.320025071949101 0.367256168710674 no 1223 0.374474662280743 1716 6812934
SGTC_526 4469-0568 170 µM 0.317695384050402 0.36818604646745 no 1224 0.375358006478581 1703 2901964
SGTC_2551 apiole 73.87 µM 0.317405765522233 0.36830169968377 no 1225 0.375467866488349 1790 10659 A possible DNA adduct former.
SGTC_3075 9116269 49.47 µM 0.317031234823045 0.36845127852821 no 1226 0.375609950916663 1766 17015205 YNL244C SUI1
SGTC_793 0488-0545 106 µM 0.316590311596368 0.368627398554197 no 1227 0.375777244072498 1707 292548
SGTC_504 lovastatin 124 µM 0.316160387080257 0.368799151889209 no 1228 0.375940386633899 1693 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1802 st050112 57.9 µM 0.316083266493043 0.368829964066261 no 1229 0.37596965376926 1772 4662563
SGTC_1817 st052116 64.4 µM 0.314798787622273 0.369343278879839 no 1230 0.376457216154097 1820 4361398
SGTC_2354 9060492 162 µM 0.314720862997015 0.369374427314498 no 1231 0.376486801128455 1867 6471895
SGTC_357 1325-0123 420 µM 0.314501739414859 0.369462021122583 no 1232 0.376569997788415 1876 1098503
SGTC_1813 st051246 8.6015 µM 0.31152937739206 0.370650879053679 no 1233 0.377699106640868 1879 5291959
SGTC_160 3453-0671 289.699 µM 0.31102958405867 0.370850903490107 no 1234 0.377889065720687 1706 5322268
SGTC_3173 9105693 49.47 µM 0.310366574283426 0.371116303338588 no 1235 0.378141104896772 1828 17096658
SGTC_1306 1185-0270 9.02 µM 0.310312689966897 0.371137875685085 no 1236 0.37816159097583 1850 1548076
SGTC_2258 7960471 200 µM 0.306684788624104 0.372591218028061 no 1237 0.379541654559344 1748 2974708
SGTC_381 3461-2219 42.7 µM 0.305853196811443 0.372924611447046 no 1238 0.379858211395757 1882 2883159
SGTC_61 0978-8327 98.565 µM 0.305322855191765 0.373137280402357 no 1239 0.380060135276764 1849 6150059 YHR072W ERG7
SGTC_818 4072-2707 53.5 µM 0.304494080407728 0.373469699552583 no 1240 0.380375750966063 1706 882871
SGTC_862 0452-0056 10.2 µM 0.303181916816743 0.373996197051378 no 1241 0.380875614578936 1842 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_117 lucigenin 22.078 µM 0.302632232931702 0.374216824245476 no 1242 0.381085073673136 1676 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_266 formosanin C 406 nM 0.302342443841235 0.374333153785923 no 1243 0.381195512918364 1815 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1040 k898-0338 155 µM 0.301957236165146 0.374487804758016 no 1244 0.38134233137072 1953 20969351
SGTC_2496 diffractaic acid 79.83 µM 0.301878080661564 0.374519586158273 no 1245 0.381372502897199 1902 94870 An apoptosis inducer which activates caspases.
SGTC_3054 9094397 49.47 µM 0.301245578489726 0.374773570105734 no 1246 0.381613618220136 1727 2598354
SGTC_2243 6634756 200 µM 0.300098458387652 0.375234339627577 no 1247 0.382051027536301 1894 885676
SGTC_2021 4019055 173 µM 0.298985462956662 0.3756815723499 no 1248 0.382475568700829 1815 44827708 YER133W GLC7
SGTC_2035 5154463 94.595 µM 0.298911930897639 0.375711125480234 no 1249 0.382503621762969 1881 2769623
SGTC_40 0327-0103 19.753 µM 0.298058159919313 0.376054316296698 no 1250 0.382829387250964 1729 409036
SGTC_742 0kpi-0133 140 µM 0.296162370573971 0.376816718052394 no 1251 0.383553042169765 1912 2728852
SGTC_941 3237-0776 460 µM 0.296035239234641 0.376867861824266 no 1252 0.38360158492375 1891 760008
SGTC_1003 4049-0218 100 µM 0.295991719455884 0.376885369928613 no 1253 0.383618202567303 1848 295161
SGTC_302 1094-0063 18.9 µM 0.295349376920736 0.37714381519471 no 1254 0.383863500278311 1792 5440289
SGTC_2414 st077232 92.9 µM 0.294692069185418 0.37740833866338 no 1255 0.384114561078184 1678 729801
SGTC_1444 4112-3581 28 µM 0.294612651320952 0.377440303068485 no 1256 0.384144898281637 1808 2877249
SGTC_1685 st024049 53.0905 µM 0.293735787737489 0.377793282232192 no 1257 0.384479902670564 1819 1941139
SGTC_1666 st014829 29 µM 0.29245403936655 0.378309430291995 no 1258 0.384969747873953 1778 3858230
SGTC_156 3474-0145 5.642 µM 0.291995169737353 0.378494265644073 no 1259 0.385145158557286 1932 2265471
SGTC_2063 5246145 200 µM 0.289972466112155 0.379309353270285 no 1260 0.385918650956458 1849 711240
SGTC_1108 betulinic acid 729.144 nM 0.289744827992594 0.379401118133169 no 1261 0.386005729422464 1775 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_202 3594-0513 34.79 µM 0.289716995402567 0.37941233839782 no 1262 0.386016376624131 1859 708429
SGTC_903 1134-0042 114 µM 0.28913406377464 0.379647361310256 no 1263 0.386239393576559 1786 701009
SGTC_2978 9011784 42.97 µM 0.287957427725369 0.380121885837617 no 1264 0.386689663363964 1953 2994934
SGTC_98 0074-0023 107.663 µM 0.286766498909075 0.38060235830111 no 1265 0.387145558018994 1749 3563821
SGTC_2398 5228213 48.84 µM 0.284335776178446 0.381583588550803 no 1266 0.388076535814404 1983 80771 YMR134W ERG29
SGTC_987 1497-1013 404 µM 0.283900252019363 0.381759480868602 no 1267 0.388243411678238 1844 1676435
SGTC_1850 st056238 17 µM 0.283614456361678 0.381874916577395 no 1268 0.388352928637621 1830 5393177
SGTC_1765 st044815 90.4 µM 0.283229541824356 0.382030403986087 no 1269 0.38850044200161 1740 645695
SGTC_739 1486-1183 203 µM 0.28248794252965 0.382330028928735 no 1270 0.388784695367798 1933 4346692
SGTC_161 4065-0411 162.148 µM 0.282237847058481 0.382431089747002 no 1271 0.388880569843571 1828 1906281 YLR208W SEC13
SGTC_1872 amphotericin b 148 nM 0.279544373353781 0.383519998947648 no 1272 0.389913544835891 1904 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_511 blebbistatin 171 µM 0.279426670304037 0.383567604628451 no 1273 0.389958702965114 1891 3476986 A myosin inhibitor.
SGTC_2991 9074669 71.4286 µM 0.276958278374045 0.384566363959281 no 1274 0.390906071220929 1880 17333109
SGTC_91 0417-1751 58.384 µM 0.276886373447749 0.38459546961339 no 1275 0.390933678052357 1894 6795624
SGTC_3056 9094900 49.47 µM 0.275416652505415 0.3851905251254 no 1276 0.391498075885755 1723 25236784
SGTC_2608 thymoquinone 42.66 µM 0.27506397737267 0.385333355294685 no 1277 0.391633543171273 1884 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1613 st002381 52.1 µM 0.273039155716324 0.386153689816118 no 1278 0.39241155838815 1950 551167
SGTC_1058 3448-5425 97.3 µM 0.272187533817699 0.386498867531461 no 1279 0.392738913342118 1915 7279705
SGTC_1189 1431-2119 7.28 µM 0.271038129935556 0.386964884049824 no 1280 0.393180853009752 1827 3107275
SGTC_3010 9080089 71.4286 µM 0.270569222522552 0.387155045622326 no 1281 0.393361184988412 1919 17027233
SGTC_3294 9122953 26.2835 µM 0.268741446278633 0.387896543516711 no 1282 0.394064327561345 1810 16459826
SGTC_1406 3909-7906 11.9 µM 0.267405738481337 0.388438676363746 no 1283 0.394578390798777 1880 X1406
SGTC_2800 7887935 81.82 µM 0.266703213801015 0.388723902167007 no 1284 0.394848839634624 1853 2961002
SGTC_2117 5521686 200 µM 0.266451267547849 0.388826207251508 no 1285 0.3949458429867 1784 803312
SGTC_717 1532-0246 73.2 µM 0.265640048477322 0.389155662533165 no 1286 0.395258219563473 1825 9561992
SGTC_1623 st003709 20.3 µM 0.265434447971484 0.389239174438986 no 1287 0.395337400965151 1780 16192618
SGTC_1664 st014217 9.02 µM 0.265364330271527 0.389267656389072 no 1288 0.395364405864495 1944 3982782
SGTC_1240 0356-0016 42.1 µM 0.263996329386788 0.389823459941223 no 1289 0.395891373587873 1860 4305613
SGTC_3141 9094609 49.47 µM 0.26365964873583 0.389960284148999 no 1290 0.396021095590098 1752 25236309 YDL196W YDL196W
SGTC_1136 pergolide 1.05886 µM 0.262953003082072 0.390247503371882 no 1291 0.39629340138482 1823 47811 A dopamine receptor agonist.
SGTC_2639 lactacystin 53 µM 0.262602710229397 0.390389903659685 no 1292 0.396428405449621 1922 3870 A proteasome inhibitor.
SGTC_597 k018-0003 82.8 µM 0.262362125423493 0.390487714190827 no 1293 0.396521134852496 1933 6786234
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.262247143651139 0.39053446285055 no 1294 0.396565454727413 1796 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1603 st002045 67.8 µM 0.261063721174819 0.391015704130835 no 1295 0.39702168403601 1953 5887985
SGTC_1025 k007-0731 70 µM 0.25973725835269 0.391555311464124 no 1296 0.397533225342157 1789 6256118
SGTC_3039 9090270 49.47 µM 0.259288336929444 0.391737980790877 no 1297 0.397706388780948 1980 17173750
SGTC_200 k038-0079 37.545 µM 0.258996612798827 0.391856698217746 no 1298 0.397818926973107 1888 3436683
SGTC_1041 0206-0046 107 µM 0.258836319124842 0.391921934176197 no 1299 0.397880766960033 1831 50494
SGTC_348 k064-0012 10.7 µM 0.257922346381919 0.392293958749563 no 1300 0.39823341913946 1803 5066323
SGTC_2891 9063876 19.48 µM 0.257371032308432 0.392518413930318 no 1301 0.398446181358542 2019 6472478
SGTC_2866 9034245 58.44 µM 0.256743631053994 0.392773889798515 no 1302 0.398688343742875 1984 6462273
SGTC_1970 st070122 35.8 µM 0.253949064800756 0.393912388376597 no 1303 0.399767454352004 1937 102928
SGTC_2699 st077704 54.6 µM 0.253594278871661 0.394056992290523 no 1304 0.399904508490891 1862 645852
SGTC_2711 st079103 59.1 µM 0.253517151764746 0.394088429747801 no 1305 0.399934304397329 1957 54693780
SGTC_446 go6976 132 µM 0.253187971205436 0.394222613413576 no 1306 0.400061480672185 1993 3501 A protein kinase C inhibitor.
SGTC_933 2914-0560 114 µM 0.252366580534278 0.394557491098758 no 1307 0.40037886458073 2011 463887
SGTC_865 0488-0499 301 µM 0.250665526318878 0.395251251655705 no 1308 0.401036357934616 2014 9634651
SGTC_3324 9138759 60.749 µM 0.249302740694068 0.395807291991029 no 1309 0.401563305737672 1891 45595710
SGTC_2311 7694451 200 µM 0.248850011058797 0.395992060581448 no 1310 0.401738402203254 1896 2163142
SGTC_1107 amlodipine 47 µM 0.247951900834848 0.396358667588663 no 1311 0.402085811190117 1894 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1270 0831-1170 17.3 µM 0.246704937148618 0.396867827881583 no 1312 0.4025682926799 1884 6764716
SGTC_1907 st060210 83.7 µM 0.246665038193552 0.396884122333657 no 1313 0.402583733039893 1968 688793
SGTC_2150 5556613 200 µM 0.246320912452365 0.397024668331074 no 1314 0.402716911387049 1895 743190
SGTC_746 1095-0025 46.6 µM 0.245929544257406 0.397184525093714 no 1315 0.402868386514883 1932 6749286
SGTC_2803 7707263 71.43 µM 0.245514401484028 0.397354111609501 no 1316 0.403029079289432 1831 2199229
SGTC_323 4013-0906 34.3 µM 0.244593392010408 0.397730414755691 no 1317 0.403385640544959 2002 2910086
SGTC_762 1165-0429 115 µM 0.243873448501463 0.398024633301048 no 1318 0.403664416718321 1985 5967793
SGTC_118 0083-0097 135.343 µM 0.24326631979968 0.398272793024554 no 1319 0.403899546848422 1856 5207356
SGTC_1042 0350-0096 82 µM 0.243235584610633 0.398285356918968 no 1320 0.403911450963856 1818 3122515
SGTC_2877 9040724 71.43 µM 0.243227778292016 0.398288547993499 no 1321 0.403914474460909 2029 6463895
SGTC_3148 9097893 49.47 µM 0.242509789348281 0.398582077271026 no 1322 0.404192586206015 1763 17174100
SGTC_477 mead ethanolamide 10 µM 0.242120720522573 0.39874116093349 no 1323 0.404343311566686 1947 16061185
SGTC_1170 0310-0127 64.8 µM 0.241887412701981 0.398836564626609 no 1324 0.404433701886558 1909 774975
SGTC_370 0180-0345 38.7 µM 0.241512458015693 0.398989902888743 no 1325 0.404578981058342 1845 3989527
SGTC_3234 9132280 49.47 µM 0.24096617214286 0.399213335184188 no 1326 0.404790667401744 1886 17612295
SGTC_1815 st051655 58.2 µM 0.240845307413205 0.399262773626184 no 1327 0.404837506377049 2004 5984156
SGTC_1017 4239-0030 168 µM 0.240183978923245 0.399533311651167 no 1328 0.405093816589518 1798 1149593
SGTC_2041 5107442 45.335 µM 0.240012030965394 0.399603660489149 no 1329 0.405160464906854 1979 793005
SGTC_843 0310-0051 143 µM 0.239799922918106 0.399690444460847 no 1330 0.405242683364959 1895 2065037
SGTC_2192 5915882 198.485 µM 0.239274587583333 0.399905406652332 no 1331 0.40544633466122 1892 2876149
SGTC_3023 9089636 49.47 µM 0.238922236980232 0.400049602148475 no 1332 0.405582941109006 2034 17249241
SGTC_3131 9127911 49.47 µM 0.238330614237971 0.400291747703095 no 1333 0.405812339304759 1909 45595681
SGTC_1088 bifonazole 369 nM 0.236101090038941 0.401204614420729 no 1334 0.406677114055373 1952 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_327 1273-0057 3.96 µM 0.235850855853321 0.401307105235385 no 1335 0.406774201916787 1978 3108138
SGTC_2585 alliin 100 µM 0.234253583749201 0.401961475021485 no 1336 0.407394059106042 1937 87310 A garlic compound which reacts with lipids.
SGTC_1134 3477-0009 42.5 µM 0.233420105035278 0.402303043517762 no 1337 0.407717601375461 2037 3973534
SGTC_2980 9014342 25.29 µM 0.233053131085484 0.402453457042081 no 1338 0.407860074397895 1900 2996599
SGTC_2818 7996756 12.99 µM 0.232868418422379 0.402529171649183 no 1339 0.407931791378596 1869 2241621
SGTC_956 1185-0240 191 µM 0.23271699924257 0.402591241825039 no 1340 0.407990584052828 1894 1416193
SGTC_1761 st044296 37 µM 0.229142530421723 0.404057208039137 no 1341 0.409379069113253 1890 1826700
SGTC_2725 haloperidol 53.21 µM 0.229101944606868 0.40407386093191 no 1342 0.409394841040207 1982 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1117 retinoic acid 1.10837 µM 0.228061523289615 0.404500818728121 no 1343 0.409799205921694 2014 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_562 3772-2733 112 µM 0.227378377306505 0.404781223308288 no 1344 0.410064766195603 2002 2876874 YIL048W NEO1
SGTC_2020 4017018 200 µM 0.225970937412822 0.405359076087429 no 1345 0.410612012149658 1886 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2912 7964298 10.93 µM 0.225166727801453 0.4056893532572 no 1346 0.410924786103663 1862 2975850
SGTC_922 1866-0035 480 µM 0.224780222031412 0.405848109451512 no 1347 0.411075126453925 1889 3156169
SGTC_1785 bathophenanthroline 24 µM 0.224134151751314 0.406113515627355 no 1348 0.411326459572909 1839 72812 An iron chelator.
SGTC_1231 0242-0792 125 µM 0.223369739684927 0.406427592424218 no 1349 0.411623876804976 1852 3707635
SGTC_1792 st045773 43.6 µM 0.221695108413461 0.40711586451334 no 1350 0.412275619144762 1894 2919270
SGTC_2415 st077333 57.7 µM 0.221450125793116 0.407216576278491 no 1351 0.412370983180429 2104 2766255
SGTC_2346 9031566 143.75 µM 0.220874704300057 0.407453154783001 no 1352 0.412594997023737 1996 4771086
SGTC_1398 3558-0053 112 µM 0.219901752998619 0.407853250252107 no 1353 0.412973835516817 1907 4532369
SGTC_122 0236-0016 402.397 µM 0.218952910739031 0.408243524217991 no 1354 0.413343364738403 1924 6808838
SGTC_809 3998-0021 90 µM 0.215521353177235 0.40965573591202 no 1355 0.414680432891289 2055 715485
SGTC_1029 k015-0030 64.7 µM 0.214970354478917 0.409882601834263 no 1356 0.414895215954988 1947 2208316
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.213960191770008 0.410298600354763 no 1357 0.415289050326615 2003 17037758
SGTC_1283 0922-0125 16.4 µM 0.213329539777023 0.41055836250253 no 1358 0.415534967203596 1987 3360884
SGTC_2753 fluvastatin 17.09 µM 0.212910135082015 0.410731134761842 no 1359 0.415698528486686 1947 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.212511915008312 0.410895196124774 no 1360 0.415853841616569 1983 688761
SGTC_2675 theaflavin digallate 100 µM 0.212485562821567 0.410906053424724 no 1361 0.415864119916498 1949 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1343 1487-0095 224 µM 0.212396023480187 0.410942944819497 no 1362 0.415899043907641 2047 4560101 YGL055W OLE1
SGTC_2512 diallyl trisulfide 49.23 µM 0.211891011070321 0.411151031363467 no 1363 0.416096031752114 2036 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1492 4158-0558 28.5 µM 0.210912440500167 0.411554315075048 no 1364 0.416477798184795 2028 3967268
SGTC_2246 7293507 91.5585 µM 0.210772101934458 0.411612158390085 no 1365 0.416532554464723 2064 887656
SGTC_2922 7999257 32.47 µM 0.2105769673476 0.41169259016112 no 1366 0.416608693348828 1972 2988377
SGTC_1115 galangin 695.678 nM 0.209600275793944 0.412095224579588 no 1367 0.416989832185294 2034 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1438 4092-1045 4 µM 0.208373425122382 0.412601116482802 no 1368 0.417468702294666 1957 1351342
SGTC_2586 curcumin 80 µM 0.208302237265308 0.41263047526294 no 1369 0.417496492437897 2007 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3098 9119039 49.47 µM 0.207284591064699 0.4130502188944 no 1370 0.417893803683355 2021 17161528
SGTC_847 0342-0274 5.54 µM 0.205868627554474 0.413634419859675 no 1371 0.418446766048477 2046 18097
SGTC_80 0159-0065 512.242 µM 0.205118925308689 0.413943810972403 no 1372 0.418739605268233 2059 1548079
SGTC_975 1335-0046 28.5 µM 0.204805595181253 0.414073133557176 no 1373 0.418862007677541 1854 16486740
SGTC_1186 1319-0216 26 µM 0.204251089191694 0.414302020900853 no 1374 0.419078644677505 2077 4565136
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.204189213319719 0.414327563647062 no 1375 0.41910282015626 2026 66535 A nucleotide analog.
SGTC_2052 5265182 7.135 µM 0.203756272869519 0.414506294298749 no 1376 0.419271982557821 2021 1239884
SGTC_2486 5283202 22.39 µM 0.203548585741748 0.414592039987016 no 1377 0.41935313724591 1864 1377751
SGTC_3337 9144342 33.5465 µM 0.20349753918483 0.414613115687016 no 1378 0.419373084445165 1998 17682949
SGTC_265 mycophenolic acid 32.932 µM 0.203273211681492 0.414705737171027 no 1379 0.419460746199862 2036 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2024 5144227 134 µM 0.202916554106896 0.41485300553124 no 1380 0.419600127569507 1998 3475211
SGTC_2268 7933382 153.85 µM 0.201781890465026 0.4153216017978 no 1381 0.420043619828254 2067 935025 YOR257W CDC31
SGTC_1474 0330-0125 5.35 µM 0.201109315995659 0.415599420218696 no 1382 0.420306548851889 2030 X1474
SGTC_836 0330-0104 1.35 µM 0.197851236213746 0.41694582078977 no 1383 0.421580728871323 2052 46494820
SGTC_1882 5615643 20 µM 0.197759140371778 0.41698389361042 no 1384 0.421616758002677 2069 2253075
SGTC_1325 1431-0015 227 µM 0.196839683183066 0.417364043832418 no 1385 0.421976497944883 1867 1103340
SGTC_520 3584-0023 682 µM 0.196301107214963 0.417586754348644 no 1386 0.422187247409231 1896 1340790
SGTC_2624 nerol 100 µM 0.195771693132275 0.417805702034145 no 1387 0.422394433465295 2007 637566 A natural product oil.
SGTC_2224 6650123 117.647 µM 0.194404414862341 0.418371279613505 no 1388 0.422929616653402 1975 2908370
SGTC_2464 5717415 7.67 µM 0.190837740997701 0.419847433591549 no 1389 0.424326359499471 1878 5285744
SGTC_955 1216-0110 33 µM 0.189515902678862 0.420394795965019 no 1390 0.424844246202001 1942 3619719
SGTC_3004 9076122 71.4286 µM 0.189502925963489 0.420400170281037 no 1391 0.4248493310299 2041 44782551
SGTC_2664 lyso-paf C-16 73.48 µM 0.187138084243096 0.42137981796178 no 1392 0.425776184337269 2019 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2037 5169046 200 µM 0.186808615397011 0.421516340881403 no 1393 0.42590534586139 2007 5718022
SGTC_2556 citropten 84.59 µM 0.186647701841298 0.421583022508181 no 1394 0.425968431620907 1955 2775 A potential DNA crosslinker.
SGTC_2452 5863136 48.41 µM 0.18575965482887 0.42195106434329 no 1395 0.426316622284517 1999 2184096
SGTC_314 1671-0008 2.74 µM 0.184812802634302 0.422343552464758 no 1396 0.42668793289632 2007 3913060
SGTC_671 0560-0003 407 µM 0.184197300945891 0.422598730928923 no 1397 0.426929338394169 2025 3238678
SGTC_1901 st060216 58.6 µM 0.183456259170921 0.422905999663798 no 1398 0.427220018189702 1988 688792
SGTC_694 1315-0438 43.2 µM 0.182504232438146 0.423300820921751 no 1399 0.427593516567067 2017 6793154
SGTC_595 3909-8003 73.7 µM 0.182269328099775 0.423398251506156 no 1400 0.427685684047014 2030 699517
SGTC_3090 9117696 49.47 µM 0.181835659557421 0.423578135239225 no 1401 0.427855849364272 2076 7923821
SGTC_2168 5727979 200 µM 0.181156421017979 0.423859912284412 no 1402 0.428122399783931 2073 695210
SGTC_3063 1327-0034 4 µM 0.179945972284626 0.424362154343471 no 1403 0.428597491781457 2060 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1317 1273-0028 910 nM 0.179742112135354 0.424446752555496 no 1404 0.42867751555352 1987 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2206 7254556 146.969 µM 0.179650517632894 0.424484763722697 no 1405 0.42871347124315 2083 4398905
SGTC_1414 3917-0015 5.4 µM 0.179154291550594 0.424690706760552 no 1406 0.428908276520009 2056 6618702
SGTC_1293 1000-1278 195 µM 0.178639994748079 0.424904171177761 no 1407 0.429110194161287 2058 678847
SGTC_3338 9144300 39.5675 µM 0.17857686699789 0.424930374547898 no 1408 0.429134979974332 2031 4901274
SGTC_2700 st077718 96.8 µM 0.177341480137372 0.425443231485567 no 1409 0.42962008534133 1949 904970
SGTC_2825 7998094 58.44 µM 0.173854502165447 0.426891489043139 no 1410 0.430989905005272 2000 2987815
SGTC_1942 st076330 65.2 µM 0.172105270736756 0.427618375493046 no 1411 0.431677384572981 2049 24208414
SGTC_1957 st077035 62.4 µM 0.170605060058574 0.428241978185499 no 1412 0.432267159455341 2137 705593
SGTC_390 dec-rvkr-cmk 16.7 µM 0.169854659345489 0.428553969660593 no 1413 0.432562219739756 2026 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.169650744154333 0.428638758489468 no 1414 0.432642406438738 1996 15053
SGTC_885 0865-0106 16.8 µM 0.169089431877863 0.428872171591178 no 1415 0.432863148689315 2040 2793380
SGTC_2896 9052656 71.43 µM 0.168852951509641 0.428970515778521 no 1416 0.432956153482139 2082 6469436
SGTC_2396 5342950 42.78 µM 0.168721752361473 0.429025078969349 no 1417 0.43300775408031 1975 1886677
SGTC_149 3970-0822 46.1 µM 0.167891962252285 0.42937020401718 no 1418 0.433334136783212 2021 3114250 YBL034C STU1
SGTC_3031 9088762 49.47 µM 0.167620244635215 0.429483228145594 no 1419 0.433441021812395 2081 205253
SGTC_827 3253-0474 693 µM 0.167163079017996 0.429673404584053 no 1420 0.433620867141774 2115 5402065
SGTC_2176 5809774 33.9695 µM 0.166894845770022 0.429784994599286 no 1421 0.433726394375269 2134 2870539
SGTC_1178 0988-0033 191 µM 0.166629599548938 0.429895347472212 no 1422 0.433830751110417 2043 5392207
SGTC_1564 D-Arginine 115 µM 0.166221430557466 0.430065172541624 no 1423 0.433991347451338 1916 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1149 3909-7961 23.3 µM 0.165439629510835 0.430390489149486 no 1424 0.434298981785768 1944 735261
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.165199340067311 0.430490485915776 no 1425 0.434393542339526 2110 165521
SGTC_2082 5219693 150 µM 0.165164127416338 0.430505140081164 no 1426 0.434407399808798 2052 2834649
SGTC_567 1080-0542 68.4 µM 0.164421357588504 0.430814274889111 no 1427 0.434699725724527 2118 5950415
SGTC_277 nystatin 15.5 µM 0.163878622097741 0.431040183839013 no 1428 0.434913348327543 2067 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1315 1237-0019 3.69 µM 0.163412179554605 0.431234354541928 no 1429 0.435096956941898 2118 825140
SGTC_902 1120-0002 2.07 µM 0.160950669581559 0.432259306116014 no 1430 0.436066126970433 2090 3280475
SGTC_2095 5432005 200 µM 0.160943864839795 0.432262140187224 no 1431 0.436068806735536 2031 783734
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.160463939663421 0.432462030490202 no 1432 0.436257812741954 2125 688662
SGTC_3157 9099274 49.47 µM 0.160022717076637 0.432645816299719 no 1433 0.436431589587074 2131 17217662
SGTC_2595 hexamethylquercetagetin 100 µM 0.159324377758143 0.432936730671661 no 1434 0.436706657697261 2027 386331
SGTC_228 caffeine 993.056 µM 0.158772799794051 0.433166532862612 no 1435 0.436923939778667 2131 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2963 9082507 9 µM 0.158724773340414 0.433186543043522 no 1436 0.436942859651733 2060 16459611
SGTC_2775 cyproheptadine 69.59 µM 0.158670446209678 0.433209178602642 no 1437 0.436964261830928 2136 2913 A selective serotonin reuptake inhibitor.
SGTC_992 3909-8734 162 µM 0.158548348207556 0.43326005189454 no 1438 0.437012363025601 1994 4288319
SGTC_2814 7977482 42.97 µM 0.157226058649266 0.433811067062936 no 1439 0.43753334593521 2092 6456762
SGTC_387 norethindrone acetate 66.7 µM 0.154207590929543 0.43506938199564 no 1440 0.438723028544493 2005 541197
SGTC_281 1672-3440 14.9 µM 0.154088624424392 0.435118989369029 no 1441 0.438769928776901 2114 6833000
SGTC_15 0266-0086 27.098 µM 0.153052522227934 0.435551072627842 no 1442 0.439178428209703 2139 1712902 YIL048W NEO1
SGTC_2846 9008642 19.48 µM 0.151709629634725 0.436111210394441 no 1443 0.439707980871234 2001 2992898
SGTC_1650 st011916 45.8 µM 0.148937633194975 0.437267849849528 no 1444 0.440801422690506 2128 242528
SGTC_2164 5685496 200 µM 0.147914401095999 0.437694938340919 no 1445 0.441205161397473 2127 759046
SGTC_1736 st036774 51 µM 0.146682746164861 0.438209117015816 no 1446 0.441691218925131 2179 1272247
SGTC_684 1140-0066 328 µM 0.145630900933904 0.438648313210265 no 1447 0.442106386310338 2038 6813534
SGTC_2981 9013952 38.96 µM 0.145605083234485 0.438659094299189 no 1448 0.442116577457801 1912 2996344
SGTC_1212 0520-0165 585 µM 0.144204429840866 0.439244054419052 no 1449 0.442669521501162 2166 5403258
SGTC_2884 9058502 51.95 µM 0.14174608814837 0.440271060952452 no 1450 0.443640284686027 2056 6471554
SGTC_89 0302-0250 142.109 µM 0.141328014665381 0.440445757164236 no 1451 0.443805409610409 2187 4203518 YLR208W SEC13
SGTC_1470 k295-0292 231 µM 0.140928000003304 0.440612918168869 no 1452 0.443963411043734 2136 5045612
SGTC_2214 7179297 48.276 µM 0.140123735157324 0.440949042149892 no 1453 0.4442811138283 2094 769744
SGTC_1428 4049-0204 61.7 µM 0.139194489087637 0.441337452117182 no 1454 0.444648231591535 2152 X1428
SGTC_1985 st071382 65.5 µM 0.138951469249879 0.441439039838447 no 1455 0.444744249420681 2185 6123237
SGTC_2667 digitoxin 100 µM 0.138796570103266 0.44150379315308 no 1456 0.444805452206431 2185 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_273 hydroxyurea 18.1 mM 0.138509557110756 0.441623778853103 no 1457 0.444918858468656 2106 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2108 5365811 200 µM 0.137932107986663 0.441865197516022 no 1458 0.44514703721468 2116 780283
SGTC_264 promethazine 12.5 mM 0.137868496140188 0.441891793539425 no 1459 0.445172174518186 2186 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.136957370683022 0.442272762499413 no 1460 0.445532245389626 2074 6708514
SGTC_480 am 92016 50 µM 0.135552028294782 0.442860482995896 no 1461 0.446087715587941 2016 2129 K+ channel blocker.
SGTC_830 4076-0286 57.8 µM 0.134889876721349 0.443137441419765 no 1462 0.446349471801628 2076 6866659
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.134750561814304 0.443195716268256 no 1463 0.446404547584611 2185 6708630 An antioxidant.
SGTC_2074 5212007 75.395 µM 0.134591159674413 0.443262395030155 no 1464 0.446467565782264 2180 758611
SGTC_1375 2910-0797 186 µM 0.134239144100666 0.443409650703789 no 1465 0.446606736750332 2086 742508
SGTC_889 0919-1524 82.7 µM 0.134100279697539 0.443467742816324 no 1466 0.446661639237448 2018 3905452
SGTC_3049 9092223 49.47 µM 0.13400234811154 0.443508711949127 no 1467 0.446700358829319 2086 8623917
SGTC_1724 st037281 8.293 µM 0.133237603868704 0.443828659172984 no 1468 0.447002736181739 2082 574124 YDL195W SEC31
SGTC_2650 prasterone 100 µM 0.132853990602704 0.443989165848031 no 1469 0.447154427217694 2162 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1642 st009582 77.7 µM 0.132634733438869 0.444080908822089 no 1470 0.447241130889795 2176 6739311
SGTC_1019 4262-0212 3.4 µM 0.132489938543399 0.444141496464396 no 1471 0.44729839037485 2182 4677213
SGTC_164 4100-3994 89.624 µM 0.132475055872303 0.444147724008994 no 1472 0.447304275824731 2180 4615967
SGTC_1205 4161-2785 76 µM 0.13238824244761 0.444184050724809 no 1473 0.447338606994039 1976 3498106
SGTC_1223 0764-0573 147 µM 0.127841732847334 0.446087166850182 no 1474 0.449137111487945 2136 1609797
SGTC_771 0250-0039 27.3 µM 0.126022175508231 0.446849163074382 no 1475 0.449857185499669 2064 3005115
SGTC_174 3553-0389 74.3 µM 0.125681980974102 0.446991651978642 no 1476 0.449991832925614 2125 738071
SGTC_566 0958-0068 16.5 µM 0.123811643635256 0.4477751558501 no 1477 0.450732206232973 2147 6815365
SGTC_1619 st003326 88.7 µM 0.123702268691314 0.447820980495329 no 1478 0.450775507651996 2194 2849032
SGTC_3026 9090633 49.47 µM 0.122972524156333 0.448126738189429 no 1479 0.451064427673924 2118 25236842
SGTC_2862 9027634 71.43 µM 0.122268180337331 0.448421882399052 no 1480 0.451343315651533 2085 5012562
SGTC_1424 4048-1941 275 µM 0.121793189193795 0.4486209361031 no 1481 0.451531404015254 2180 X1424
SGTC_2290 7904846 200 µM 0.12045457380326 0.449181976733668 no 1482 0.452061531207954 2070 2962154
SGTC_2582 agaric acid 100 µM 0.120396570267748 0.449206289486978 no 1483 0.452084504085277 2132 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_447 ml7 120 µM 0.120112562764458 0.449325336781108 no 1484 0.452196990397031 2213 4216 Selective myosin light chain kinase inhibitor.
SGTC_1917 st066507 28.5 µM 0.119136398108426 0.449734549988425 no 1485 0.45258364728162 2062 3156428
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.118901207609657 0.449833151054208 no 1486 0.452676812508099 2027 641818 YHR062C RPP1
SGTC_2766 oltipraz 83.91 µM 0.117896999473878 0.450254189194825 no 1487 0.453074635370484 2180 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_135 0933-0004 26.348 µM 0.117710822964358 0.450332254290769 no 1488 0.453148395459365 2059 21230617 YGL099W LSG1
SGTC_964 1287-0107 19.4 µM 0.117085746359588 0.450594367267159 no 1489 0.453396052399344 2169 51516812 YPR165W RHO1
SGTC_1545 lovastatin 49.4 µM 0.116997738873083 0.450631273123876 no 1490 0.453430922647125 2108 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_423 5-fluorouracil 457 µM 0.116420671565473 0.450873276317976 no 1491 0.453659576624386 1979 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2774 tamoxifen 10.92 µM 0.116334118224413 0.450909575541496 no 1492 0.453693873371077 2184 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1155 4088-0394 48.2 µM 0.116182616456207 0.450973114187184 no 1493 0.45375390675211 2041 2326248
SGTC_2710 st078562 53.7235 µM 0.115390479672867 0.451305350520869 no 1494 0.454067812338932 2190 17250908
SGTC_3175 9106517 49.47 µM 0.11472987177304 0.451582447386025 no 1495 0.454329618005604 2100 41468073
SGTC_2938 9059746 27.26 µM 0.114456323538299 0.451697196129344 no 1496 0.454438033784701 2148 6471769
SGTC_1314 1222-0010 41.1 µM 0.113617458691146 0.452049110517159 no 1497 0.454770523469702 2110 3526027
SGTC_3281 9140613 49.47 µM 0.113396830436833 0.452141673122938 no 1498 0.454857976224893 2003 16013766
SGTC_1617 st002906 78 µM 0.113327441675341 0.452170785093598 no 1499 0.454885481034822 2141 5150859
SGTC_2085 5307070 144.047 µM 0.112984313069522 0.452314748060687 no 1500 0.455021495964483 2099 2840351
SGTC_1656 st012921 11 µM 0.111940305221528 0.452752810257961 no 1501 0.455435369237076 2185 6732821
SGTC_253 dyclonine 31.25 µM 0.111545390931439 0.452918529992521 no 1502 0.455591936698822 2186 3180 An oral anasthetic.
SGTC_2107 5363541 170.161 µM 0.111532448049906 0.452923961413508 no 1503 0.455597068142047 2224 244052
SGTC_1554 st069299 38.7 µM 0.11138226648643 0.452986985062901 no 1504 0.455656610924079 2136 24207999
SGTC_710 3448-4187 58 µM 0.109701949480344 0.453692209992306 no 1505 0.456322877144123 2168 3946412
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.109521405419516 0.453767992620424 no 1506 0.456394472410364 2138 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2736 butenafine 14.65 µM 0.109424109556164 0.453808832857711 no 1507 0.456433055951805 2182 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1899 st063254 59.6 µM 0.107311467934338 0.454695740383967 no 1508 0.457270943491884 2141 3093813
SGTC_3326 9140064 16.379 µM 0.106532430828993 0.455022844991538 no 1509 0.45757996286371 2191 1868434
SGTC_3206 9114350 49.47 µM 0.105497525393407 0.455457431549235 no 1510 0.457990516741646 2225 17087243
SGTC_3065 9113888 49.47 µM 0.104779325651356 0.455759055641583 no 1511 0.458275457736693 2178 16648368
SGTC_2257 7960413 200 µM 0.103043902925037 0.456487990262855 no 1512 0.458964063444498 2151 2974689 YIL048W NEO1
SGTC_2278 7948257 134.34 µM 0.102906721644479 0.456545617190436 no 1513 0.459018501462791 2247 1247028
SGTC_1834 st055981 52.8 µM 0.102347685402102 0.456780465820625 no 1514 0.459240353262 2210 471719 YDL150W RPC53
SGTC_970 1315-0089 19.5 µM 0.102334683104555 0.456785928207748 no 1515 0.45924551333478 2221 6811083 YLR033W RSC58
SGTC_3271 9137798 49.47 µM 0.102295172154119 0.456802527178624 no 1516 0.459261193634887 2220 6498326
SGTC_1433 4060-0023 7.6 µM 0.101835702001334 0.456995561008044 no 1517 0.45944354342481 2193 3840627
SGTC_3205 9113483 49.47 µM 0.101821136181816 0.457001680605277 no 1518 0.459449324297226 2202 17018033
SGTC_1397 3532-0190 20.1 µM 0.101511299365249 0.457131856025242 no 1519 0.459572294148488 2144 5322280
SGTC_552 k242-0005 476 µM 0.10124184832968 0.457245067427655 no 1520 0.459679238599109 2128 4088318
SGTC_1949 st076024 69.1 µM 0.100925927272359 0.457377807895265 no 1521 0.459804630601611 2232 2921930
SGTC_1953 st076800 12.1 µM 0.100883757822122 0.457395526582122 no 1522 0.459821368350883 1999 297591
SGTC_1675 st018485 24.5 µM 0.100815095739811 0.457424377078613 no 1523 0.45984862161447 2096 3323024
SGTC_1951 sophoraflavanone G 9.2 µM 0.0992942052445235 0.458063483490658 no 1524 0.460452339613145 2118 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_920 mycophenolic acid 780.421 nM 0.0988450591014878 0.458252243850734 no 1525 0.460630645828431 2149 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1238 0333-0287 48.8 µM 0.0982920851093581 0.45848465233897 no 1526 0.460850181458339 2176 7226
SGTC_1522 st012842 45.6 µM 0.0981989551366561 0.458523795173624 no 1527 0.46088715606789 2186 3491067 YOR116C RPO31
SGTC_1418 3966-3099 2.4 µM 0.0981831918083946 0.458530420592286 no 1528 0.460893414482962 2203 740335
SGTC_33 0986-0033 35.816 µM 0.0979026749176388 0.458648325399969 no 1529 0.46100478795815 2232 2848082
SGTC_679 0422-0091 41.4 µM 0.097672495446407 0.458745075469522 no 1530 0.461096178278907 2193 627384 YHR062C RPP1
SGTC_547 1120-0019 610 nM 0.0972385538263932 0.458927478402869 no 1531 0.461268475786572 2195 3676939
SGTC_2053 5265679 138 µM 0.0960169656552322 0.4594410068423 no 1532 0.4617535490868 2204 764595
SGTC_1280 0880-0253 10.1 µM 0.0946057723226335 0.460034325262178 no 1533 0.462313982376775 2154 6836607
SGTC_1789 tunicamycin 25 nM 0.0941044072037542 0.460245139392759 no 1534 0.46251310973892 2221 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0937802154297681 0.460381461584255 no 1535 0.462641874105607 2180 521171
SGTC_729 4092-0585 94.1 µM 0.092985046243835 0.46071584881093 no 1536 0.462957720558622 2158 2169061
SGTC_949 1165-0505 146 µM 0.0926349403718863 0.460863085334989 no 1537 0.463096792340237 2144 6244267
SGTC_2832 7992762 51.95 µM 0.0919882313565355 0.46113507198141 no 1538 0.463353694981146 2044 2985177
SGTC_1419 3993-2473 62.6 µM 0.0901997121592361 0.461887364433017 no 1539 0.464064256529894 2176 704026
SGTC_2954 9074818 52.69 µM 0.0895077058800953 0.462178474983693 no 1540 0.464339214879982 2202 16648742
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0894430060121967 0.462205693714423 no 1541 0.464364923277925 2188 5393153
SGTC_2838 9002687 71.43 µM 0.0884135860702578 0.462638786395803 no 1542 0.46477398173043 2128 6457060
SGTC_497 capsazepine 133 µM 0.0877038993483933 0.462937388256998 no 1543 0.465056010168688 2205 2733484 A calcium channel blocker.
SGTC_1507 4075-3230 155 µM 0.0869087265058424 0.463271983347036 no 1544 0.465372031510141 2260 659771
SGTC_2316 5844804 197.44 µM 0.086062794565264 0.463627965514444 no 1545 0.465708249743004 2250 776813
SGTC_1837 st055472 66.5 µM 0.083237396361339 0.464817149342073 no 1546 0.466831388951163 2212 676091
SGTC_560 2332-1943 155 µM 0.0821709113728512 0.465266105241527 no 1547 0.467255402281204 2262 21177716
SGTC_900 1112-0045 141 µM 0.0813589080612101 0.465607962214344 no 1548 0.467578263674372 2261 56211 YIL048W NEO1
SGTC_1437 4092-1038 11.6 µM 0.0804283159698078 0.46599977678337 no 1549 0.467948303480398 2242 3977136
SGTC_3176 9106582 49.47 µM 0.080223191833727 0.466086146271567 no 1550 0.468029872594724 2253 17018027
SGTC_2643 anethole 100 µM 0.0795351436852114 0.466375867196315 no 1551 0.468303489760795 2239 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1693 xanthone 101.9 µM 0.0789050777970724 0.466641188785683 no 1552 0.468554062169547 2191 7020 An insecticide.
SGTC_2408 sulbentine 18.36 µM 0.0787288093087397 0.4667154183411 no 1553 0.46862416504025 2132 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1410 3909-8106 77.9 µM 0.0786958116316427 0.466729314333596 no 1554 0.468637288491753 2250 1039210
SGTC_1121 fusaric acid 630.51 nM 0.077759245737659 0.467123738113428 no 1555 0.469009782718386 2122 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2557 derrustone 83.84 µM 0.0770054003829594 0.467441234743023 no 1556 0.469309624421287 2092 629853 An antioxidant.
SGTC_1734 st037168 69.4 µM 0.0768560569703191 0.467504136090032 no 1557 0.469369027777947 2087 708907
SGTC_726 3448-4391 34.2 µM 0.0760951747350558 0.467824621561996 no 1558 0.46967168950782 2221 1356692
SGTC_2288 7946289 167.31 µM 0.07580969884475 0.467944870101865 no 1559 0.469785249885266 2260 1246052
SGTC_438 sphingosine 6.67 µM 0.0739888533200827 0.468711917476272 no 1560 0.470509627355922 2220 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1600 coumarin 106 71.1 µM 0.0737080652511409 0.468830212356633 no 1561 0.47062134055313 2232 100336 A hepatotoxic, DNA x-linker.
SGTC_3319 9138450 16.7555 µM 0.0731194078935412 0.469078220245508 no 1562 0.470855548865379 2150 2029690
SGTC_890 0929-0006 47.2 µM 0.0718951851555504 0.46959403720922 no 1563 0.471342660912407 2185 1378169
SGTC_2367 9070478 135.38 µM 0.0692083886831737 0.47072627622543 no 1564 0.472411872958476 2260 572802
SGTC_1874 staurosporine 7.6 µM 0.0671586604671095 0.471590208877318 no 1565 0.473227697477689 2260 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_73 0327-0325 16.231 µM 0.0670638575435587 0.471630170290406 no 1566 0.473265433296852 2306 53298
SGTC_2134 5324836 1.464 µM 0.0668180290086382 0.471733793483772 no 1567 0.473363285205522 2246 699272
SGTC_3016 9080866 49.47 µM 0.066567704726756 0.471839313718984 no 1568 0.473462928295347 2292 17066299
SGTC_2743 auranofin 4.32 µM 0.0652716467799416 0.472385677861057 no 1569 0.473978858391248 2259 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1888 azatryptophan 97.5 µM 0.065259116600785 0.472390960318878 no 1570 0.473983846574415 2173 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_986 1493-0483 84 µM 0.064748045739562 0.472606421084224 no 1571 0.474187304041368 2294 40079
SGTC_2386 9075165 157.42 µM 0.0644753359508518 0.472721395234621 no 1572 0.474295872650259 2210 16452277
SGTC_2737 bleomycin 30.5 nM 0.0643106675602155 0.472790820350208 no 1573 0.474361429777507 2283 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3218 9131285 49.47 µM 0.0635705792779802 0.473102855889846 no 1574 0.474656079338633 2280 17156417
SGTC_2834 9001755 58.44 µM 0.0631818957076224 0.473266739026379 no 1575 0.474810830552497 2162 2989575
SGTC_1060 3448-7350 82 µM 0.0630223707799751 0.473334001851864 no 1576 0.474874345211032 2283 570178
SGTC_1919 st067113 52.3 µM 0.0620298322910201 0.473752517360024 no 1577 0.475269537502716 2234 1268243
SGTC_2004 4023728 41.89 µM 0.0609287668296551 0.474216828417571 no 1578 0.475707969691198 2292 360084 YDR527W RBA50
SGTC_651 3253-0966 34.4 µM 0.0608394403865042 0.474254498254 no 1579 0.47574353979803 2261 781462
SGTC_1633 st005664 67.9 µM 0.0606620675922018 0.474329298781526 no 1580 0.47581417084726 2285 2063822
SGTC_2301 7769476 200 µM 0.0605387442942011 0.474381306432476 no 1581 0.475863279468645 2240 977820
SGTC_2923 7992654 58.14 µM 0.058854211218601 0.475091747640218 no 1582 0.476534114473391 2263 2985126
SGTC_1291 0993-0025 5.79 µM 0.0585914833572742 0.475202558657038 no 1583 0.476638747163337 2283 4353356
SGTC_1446 4239-0190 62 µM 0.0581220778453181 0.475400545101588 no 1584 0.476825694270346 2192 1340085
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.057047263664882 0.475853904370831 no 1585 0.477253772728352 2292 91467 include heat shock
SGTC_833 3852-0053 558 µM 0.0569927728961554 0.475876889548868 no 1586 0.477275476089314 2261 3123681
SGTC_1015 4130-4525 82 µM 0.0567423098521789 0.475982540358856 no 1587 0.477375234950539 2231 1363237
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0561349066755755 0.476238763350303 no 1588 0.477617168131345 2196 689007
SGTC_886 0866-0150 153 µM 0.0560167047724221 0.476288626014926 no 1589 0.47766424978585 2308 271463
SGTC_3128 9127691 49.47 µM 0.0559567255234909 0.476313927993023 no 1590 0.477688140571854 2249 41316314
SGTC_2976 9009005 19.48 µM 0.0555116514166986 0.476501683492621 no 1591 0.477865423888004 2305 2993148
SGTC_481 bay k-8644 50 µM 0.0550336334675396 0.476703342234591 no 1592 0.478055834376434 2246 2303 A calcium channel antagonist.
SGTC_2823 7987624 58.44 µM 0.0542337550021119 0.477040795780029 no 1593 0.478374463822927 2256 2239440
SGTC_2425 5628681 7.85 µM 0.054014975888332 0.477133097414082 no 1594 0.478461616313476 2275 5714958
SGTC_2218 6965428 192.983 µM 0.0539096148075643 0.477177549078455 no 1595 0.478503588149266 2280 675684
SGTC_2999 9069765 71.4286 µM 0.0526229225582464 0.477720425136716 no 1596 0.479016176355948 2291 2097066
SGTC_2432 5630864 12.22 µM 0.0513137150463744 0.478272843175429 no 1597 0.479537769738058 2268 5714970
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0507023036712958 0.478530841602564 no 1598 0.479781370474015 2273 368090
SGTC_3122 9126309 49.47 µM 0.0494277825924956 0.479068682498089 no 1599 0.480289193954365 2325 17591206
SGTC_2375 9072683 200 µM 0.0491560689997901 0.479183349104294 no 1600 0.480397460387249 2326 16798029
SGTC_1388 3346-4487 254 µM 0.0475875960410663 0.479845298107408 no 1601 0.481022458877858 2276 3345614
SGTC_791 1348-1292 225 µM 0.0469970303737735 0.480094551434378 no 1602 0.48125779716683 2293 5437054
SGTC_287 k060-0039 29.6 µM 0.0446210413969411 0.481097435707777 no 1603 0.482204685376375 2330 5861974
SGTC_1856 st057054 55.7 µM 0.0441109100712003 0.481312773520117 no 1604 0.482407998135773 2324 1266018
SGTC_2083 5306046 65.942 µM 0.0401303392229813 0.482993243658464 no 1605 0.48399460703754 2314 539837
SGTC_2794 7785382 27.27 µM 0.0394559727543807 0.483277970438731 no 1606 0.484263427407089 2354 2205081
SGTC_2251 lansoprazole 556 µM 0.0393563925351066 0.483320015300387 no 1607 0.48430312333401 2227 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_315 k915-0449 187 µM 0.0390698660664978 0.483440993830985 no 1608 0.484417343006581 2270 20970215 YNL149C PGA2
SGTC_721 1187-1332 279 µM 0.0388595420072724 0.483529798798794 no 1609 0.484501186494462 2318 25730
SGTC_3343 9148379 18.9835 µM 0.038199525709937 0.483808482263464 no 1610 0.484764299525019 2342 1955036
SGTC_501 nsc-95397 161 µM 0.0380101937248835 0.483888426745647 no 1611 0.4848397772428 2320 262093
SGTC_1144 3486-0183 12.5 µM 0.0370130093414323 0.484309493469682 no 1612 0.485237316447109 2256 6744069
SGTC_2666 tannic acid 100 µM 0.0365579419461308 0.484501654084062 no 1613 0.485418739280351 2344 16134267 A thiamine antagonist.
SGTC_2011 4012611 177 µM 0.0361683324367801 0.484666176758638 no 1614 0.485574068257515 2318 2049887
SGTC_2739 tacrine 100.86 µM 0.0356360976517438 0.484890930851562 no 1615 0.485786262413936 2300 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3185 9108267 49.47 µM 0.0343609955778654 0.485429405108454 no 1616 0.486294643055967 2285 4910486
SGTC_3226 9131256 49.47 µM 0.0310353952216749 0.486833925163163 no 1617 0.487620655977605 2343 17178073
SGTC_271 rotenone 740 µM 0.0303443225002612 0.487125810980582 no 1618 0.487896224294553 2297 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_17 0960-0276 49.807 µM 0.03026443423725 0.487159553537056 no 1619 0.487928080469365 2346 6821114
SGTC_2245 6637752 200 µM 0.0301585303974824 0.487204284483457 no 1620 0.487970310711805 2340 681890
SGTC_2160 5660466 132.927 µM 0.0296282120212552 0.487428279176616 no 1621 0.488181782623474 2369 2859134
SGTC_505 gw-5074 63.9 µM 0.0295638949805076 0.48745544553593 no 1622 0.488207430175231 2331 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2455 5377712 9.75 µM 0.0295041501686074 0.487480680720301 no 1623 0.488231254513972 2234 2243908
SGTC_1031 k035-0009 16 µM 0.0294496311922334 0.487503708645072 no 1624 0.488252994991667 2342 5180959
SGTC_2807 7945238 51.95 µM 0.0293076877435323 0.487563663433678 no 1625 0.488309597802358 2333 17148797
SGTC_1417 3966-0327 90.4 µM 0.0287113953904204 0.487815531454991 no 1626 0.488547383954036 2336 651118
SGTC_3231 9132313 49.47 µM 0.0282341158405884 0.488017133145923 no 1627 0.488737713778604 2287 4905967
SGTC_1222 0366-0074 1.18 µM 0.0277086400537381 0.488239096346457 no 1628 0.488947266292127 2352 286520
SGTC_112 phenothiazine 287.218 µM 0.0274855934535027 0.488333313281465 no 1629 0.48903621513307 2355 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1225 1216-0074 20.6 µM 0.0266609905023139 0.488681638762784 no 1630 0.489365063566553 2333 4241466
SGTC_911 3456-4043 236 µM 0.0258629530785682 0.489018750763544 no 1631 0.489683324657929 2345 914281
SGTC_467 ro 31-8220 72.8 µM 0.024594916429373 0.489554418840163 no 1632 0.490189037088143 2360 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_430 0958-0115 16.4 µM 0.0241865509653626 0.489726932377372 no 1633 0.490351902884182 2269 6833180
SGTC_838 0109-0203 71.4 µM 0.0238540841928501 0.489867384017303 no 1634 0.490484499677876 2357 759422
SGTC_3134 9127454 49.47 µM 0.0235665663744127 0.489988847843135 no 1635 0.490599170454312 2366 24262820
SGTC_154 3389-1638 511.116 µM 0.0235543133254268 0.489994024246355 no 1636 0.490604057357082 2283 5238686
SGTC_2809 7964133 12.99 µM 0.0230442505313929 0.490209506032629 no 1637 0.490807487744825 2332 1253665
SGTC_2868 9035608 32.47 µM 0.0221160446963827 0.490601644355086 no 1638 0.491177693894787 2367 6462614
SGTC_2381 9035592 200 µM 0.0215918852343671 0.490823089590719 no 1639 0.49138675333455 2281 4749657
SGTC_1241 0364-0022 50.8 µM 0.020427423549448 0.491315057711763 no 1640 0.491851203791513 2350 4563895
SGTC_1445 4239-0156 97.7 µM 0.0201547871483692 0.491430244561239 no 1641 0.491959947589954 2354 4008346
SGTC_1892 st058411 7.36 µM 0.0199563600490086 0.491514078983167 no 1642 0.492039092630638 2372 3934738
SGTC_1974 st069448 26.9 µM 0.0193940264332725 0.491751664047903 no 1643 0.492263387864663 2364 6323587 YNR016C ACC1
SGTC_2905 7799065 20.05 µM 0.0193315359186863 0.491778066373848 no 1644 0.492288313300125 2367 1296806
SGTC_3308 9128332 17.569 µM 0.0185918692843708 0.492090579220364 no 1645 0.492583344543787 2367 17332805 YDL196W YDL196W
SGTC_810 3825-7150 143 µM 0.0185448147766886 0.4921104601511 no 1646 0.492602113340521 2369 22330411 YGL099W LSG1
SGTC_2572 astragaloside iv 100 µM 0.0180967469015111 0.49229977362391 no 1647 0.492780836562092 2333 45006101 An anti-inflammatory agent.
SGTC_2444 5485484 36.41 µM 0.0167155578802148 0.492883351495289 no 1648 0.493331767750854 2352 6790631
SGTC_948 3448-0295 75.3 µM 0.0164392748442332 0.493000088048958 no 1649 0.493441973591 2387 678569
SGTC_2040 5100729 123 µM 0.0142991888613105 0.493904347918852 no 1650 0.494295643380366 2373 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_618 k072-0232 33.2 µM 0.0139335472120232 0.4940588473421 no 1651 0.494441498759771 2363 5872756 YGL099W LSG1
SGTC_2064 5220758 200 µM 0.0116273920788212 0.495033317297075 no 1652 0.495361446208366 2360 788518
SGTC_1345 1488-0192 31.4 µM 0.0115428774760994 0.495069029691273 no 1653 0.495395160394137 2377 658348
SGTC_2770 toltrazuril 17.5 µM 0.0107118868622616 0.495420174197578 no 1654 0.495726657151703 2386 68591 Kills coccidiodes.
SGTC_229 benomyl 22.8748 µM 0.0103599810877232 0.495568877058085 no 1655 0.495867039451311 2371 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_658 3253-0951 102 µM 0.0100839297171817 0.495685526978118 no 1656 0.495977162260806 2379 1184878
SGTC_3250 9135583 49.47 µM 0.00980776560721357 0.495802224907125 no 1657 0.496087330351209 2388 7699353
SGTC_2340 7987427 183.45 µM 0.00869459634384489 0.496272617404097 no 1658 0.496531401609502 2386 2239331
SGTC_49 0717-0965 32.132 µM 0.00862274403496771 0.496302980255553 no 1659 0.49656006545893 2381 5889349 YGL099W LSG1
SGTC_2003 4023581 200 µM 0.00843812724507 0.496380994438832 no 1660 0.49663371422229 2379 16641307
SGTC_2451 5856223 45.7 µM 0.00775738165650081 0.496668660732299 no 1661 0.496905283510486 2382 2179896
SGTC_125 0133-0007 11.75 µM 0.0060646744287261 0.497383964239357 no 1662 0.497580559784801 2394 26541
SGTC_2468 5987765 72.9 µM 0.00467741690235162 0.497970197314356 no 1663 0.498133987438765 2382 26772094
SGTC_2916 7875993 68.79 µM 0.00408100591122941 0.498222232581227 no 1664 0.49837191871462 2398 1299250
SGTC_1744 st037937 38.9 µM 0.00369809160929735 0.498384047397779 no 1665 0.498524678262975 2396 1016152
SGTC_1767 st044992 70.3 µM 0.00337997975490484 0.498518477710137 no 1666 0.498651585736308 2394 9600693
SGTC_1262 0737-0114 49.6 µM 0.00329117758827797 0.498556004487576 no 1667 0.498687012478074 2397 765919
SGTC_2431 5490079 200 µM 0.00320197953382816 0.498593698575531 no 1668 0.498722597165775 2398 5722345
SGTC_2489 cantharidin 73.42 µM 0.00261480817932941 0.498841830840001 no 1669 0.498956843650841 2397 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3316 9136639 10.545 µM 0.00255437042630781 0.498867371207887 no 1670 0.498980954745318 2377 4903665
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.00238004510429063 0.49894103930743 no 1671 0.499050500275061 2398 3256 An antibiotic and ribosome inhibitor.
SGTC_3006 9075424 71.4286 µM 0.00200866053512613 0.499097982748195 no 1672 0.499198660924427 2401 7465181
SGTC_1659 st012954 42.1 µM 0.0017978507588914 0.499187068935456 no 1673 0.499282761704811 2396 24207262
SGTC_1499 4480-0877 67.3 µM 0.0013966708038615 0.499356603840641 no 1674 0.499442809145688 2403 2861909
SGTC_1094 duloxetine 25.4 µM 0.000970207524259308 0.499536823369549 no 1675 0.499612943258532 2403 60834 A selective serotonin reuptake inhibitor.
SGTC_2819 7996655 46.38 µM 0.00045998291956098 0.499752439798697 no 1676 0.499816493371596 2405 6456960
SGTC_1333 1482-0047 286 µM 0.00036010348166519 0.499794647980883 no 1677 0.499856339498949 2404 3811116
SGTC_823 0417-1665 178 µM 0 0.499946824597471 no 1678 0.5 2406 3429856
SGTC_1557 sumaresinolic acid 42.3 µM -0.000251663454664991 0.499946824597471 no 1679 0.499899600808562 2407 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1064 honokiol 6.76 µM -0.000646013814832062 0.499780175547459 no 1680 0.499742277793466 2410 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1824 st053723 68.6 µM -0.00109790786372813 0.499589209081399 no 1681 0.499561998221168 2410 675225
SGTC_432 NS 1619 61.3 µM -0.00156786903111687 0.499390607709815 no 1682 0.49937451100962 2427 4552 A K+/calcium channel activator.
SGTC_735 3076-0345 636 µM -0.00183942260393854 0.499275851672735 no 1683 0.499266176965575 2408 2888990
SGTC_1628 st004252 77.7 µM -0.00275682611785632 0.498888165901891 no 1684 0.498900186894985 2412 692968
SGTC_2256 7954252 200 µM -0.00403596589633434 0.498347615749241 no 1685 0.498389886932889 2424 2972920
SGTC_1977 st070720 65.3 µM -0.00484252268789641 0.498006775373796 no 1686 0.498068120506435 2433 682188
SGTC_410 α-linolenic acid 100 µM -0.00515777602382954 0.497873553809483 no 1687 0.497942354194397 2451 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3106 9121286 49.47 µM -0.00660835345749466 0.497260563756635 no 1688 0.497363667590236 2466 15943471
SGTC_3265 9137266 49.47 µM -0.00671560192230575 0.497215242566714 no 1689 0.497320882592586 2418 17224265
SGTC_457 grayanotoxin iii 135 µM -0.00741381168911409 0.49692019311818 no 1690 0.4970423441527 2428 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1516 st013856 110 µM -0.00861841584094608 0.496411155607798 no 1691 0.496561792094365 2475 5281404 A mutagen and neurotoxin.
SGTC_2459 5811157 9.22 µM -0.00954171758448528 0.496020993820932 no 1692 0.496193463188614 2427 2870684 YBR192W RIM2
SGTC_1546 5-methoxyflavanone 78.7 µM -0.011003151925299 0.495403440006246 no 1693 0.495610466052502 2425 147795
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0112022302107581 0.495319316926916 no 1694 0.49553105020239 2425 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1310 1188-0297 994 nM -0.0116289957276081 0.495138982397882 no 1695 0.495360806488313 2432 1588352
SGTC_1999 st074831 12.5 µM -0.0116352903285676 0.495136322551384 no 1696 0.495358295475737 2438 17112523
SGTC_748 act1.228 77.9 µM -0.0125281463970829 0.494759039549613 no 1697 0.495002123447316 2434 4421505 YNR035C ARC35
SGTC_2272 7805186 180 µM -0.0128417074478224 0.494626543080109 no 1698 0.49487704075097 2423 2956062 YPR165W RHO1
SGTC_184 1494-0393 24.714 µM -0.0129259466873794 0.494590947554695 no 1699 0.494843436945766 2424 3090647
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0131283851745935 0.494505406784462 no 1700 0.494762682526762 2438 4330530
SGTC_1477 0139-0234 16 µM -0.013175312801431 0.494485577461851 no 1701 0.494743962731361 2426 620880
SGTC_2957 9076800 11.52 µM -0.0134701502597832 0.494360993868942 no 1702 0.49462635004211 2442 16459615
SGTC_72 0744-0168 198.391 µM -0.0135641033405947 0.494321294101692 no 1703 0.494588871609863 2458 677577
SGTC_2407 paclitaxel 400 µM -0.0137861615872653 0.49422746386683 no 1704 0.494500291469777 2531 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1105 epirubicin 18.1 µM -0.0161528219869401 0.493227457479933 no 1705 0.493556236573811 2429 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3041 9091929 49.47 µM -0.0181837136970735 0.492369360163275 no 1706 0.492746147538354 2445 25236887
SGTC_2032 5185112 25.99 µM -0.0189265312211932 0.492055511701838 no 1707 0.492449857237836 2437 5718189
SGTC_814 3342-0569 96 µM -0.0194513105512394 0.491833789695587 no 1708 0.492240539118151 2444 4346283
SGTC_3142 9086498 49.47 µM -0.0197478734824284 0.49170849142055 no 1709 0.492122250348677 2443 25236367
SGTC_3048 9093155 49.47 µM -0.0198869390079648 0.491649736312292 no 1710 0.492066782123915 2441 25236002
SGTC_1845 st056753 3.01 µM -0.0208851681414278 0.491227990445782 no 1711 0.491668629076619 2431 5375839
SGTC_703 3875-0075 71.8 µM -0.0216712088743343 0.490895899793083 no 1712 0.491355115183729 2456 2850814
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.021731939992545 0.490870242048229 no 1713 0.491330892677509 2467 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1148 3909-7663 27.7 µM -0.0220057291235838 0.490754571807077 no 1714 0.491221692732901 2504 4084526
SGTC_2682 pyrogallin 40.03 µM -0.0225341950419908 0.490531308101644 no 1715 0.491010917610319 2445 822798 An ATP competetive kinase inhibitor.
SGTC_1463 k081-0032 34.1 µM -0.0225413850235032 0.490528270533596 no 1716 0.491008049951107 2441 977755
SGTC_1680 diphenhydramine 100 µM -0.0226283586968843 0.490491526609069 no 1717 0.490973361323579 2505 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3014 9081533 49.47 µM -0.0233217499383589 0.490198591273641 no 1718 0.490696811244577 2458 21367265
SGTC_2300 7976697 71.57 µM -0.0233385181786406 0.490191507300203 no 1719 0.490690123504861 2457 2236109
SGTC_778 3456-2434 196 µM -0.0241505880860785 0.489848440958476 no 1720 0.490366245807648 2465 5539063
SGTC_1349 flufenamic acid 69 µM -0.026575754209719 0.488823953106088 no 1721 0.489399055882931 2456 3371 A non-steroidal anti-inflammatory.
SGTC_3344 9148862 3.898 µM -0.0266382147992356 0.48879756818228 no 1722 0.489374146531537 2480 4905352
SGTC_635 k038-0028 24.7 µM -0.0278110349673297 0.488302148678513 no 1723 0.488906432368333 2470 4035102
SGTC_589 1227-0070 34.1 µM -0.0280431863140247 0.488204086054176 no 1724 0.488813853490154 2483 2841384
SGTC_3244 9134489 49.47 µM -0.028130881572817 0.488167043046092 no 1725 0.488778881940567 2488 16584271
SGTC_3323 9138564 53.9225 µM -0.0282141848425222 0.488131855335315 no 1726 0.488745661930033 2457 43912313 YNL103W MET4
SGTC_1530 rhein 70.4 µM -0.028367719858742 0.488067001631688 no 1727 0.488684434827917 2440 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_331 k048-0133 24.5 µM -0.0286287563389836 0.487956739675832 no 1728 0.488580338618947 2453 6813582
SGTC_1356 1502-0781 85.8 µM -0.0287729017742022 0.48789585295701 no 1729 0.488522856590291 2457 567702
SGTC_2335 9018011 154.17 µM -0.0288918794168702 0.487845597271574 no 1730 0.488475411103212 2500 6458208
SGTC_2227 7312221 64.1025 µM -0.0289531522298011 0.487819715953105 no 1731 0.488450977009341 2464 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_963 1269-2853 151 µM -0.0290476986219229 0.487779780147997 no 1732 0.488413274313861 2469 3668223
SGTC_2057 5236571 38.335 µM -0.0295466067127555 0.487569046527383 no 1733 0.488214324184531 2465 54684039 YBR257W POP4
SGTC_805 3852-0218 479 µM -0.0295937142812688 0.487549148955781 no 1734 0.488195539198265 2461 6615355
SGTC_2145 5634607 200 µM -0.0311698538937007 0.486883428019334 no 1735 0.487567040667689 2452 308662
SGTC_2442 5158906 48.48 µM -0.0313771030778997 0.486795893959886 no 1736 0.487484400627802 2498 1893835
SGTC_687 k029-0044 34.9 µM -0.0325022052210295 0.486320705431909 no 1737 0.487035778724069 2468 5829338
SGTC_786 4544-0069 423 µM -0.0328952300883175 0.486154715349952 no 1738 0.486879068288544 2569 748821 YLR208W SEC13
SGTC_2355 9061122 103.12 µM -0.0332199412992523 0.486017578658918 no 1739 0.486749598020293 2479 5302957
SGTC_2733 amorolfine 100 µM -0.0345583540259582 0.485452338652125 no 1740 0.486215955160354 2479 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3107 9121808 49.47 µM -0.0354313927276142 0.485083651620394 no 1741 0.485867876321988 2476 662681
SGTC_2365 9042475 200 µM -0.0360888343000869 0.484806020344299 no 1742 0.485605762733699 2491 6464479
SGTC_2977 9011197 71.43 µM -0.0367220119109614 0.484538642467788 no 1743 0.485353328755668 2560 2704722
SGTC_2677 mitomycin C 100 µM -0.0373607995036709 0.484268902656286 no 1744 0.485098664149299 2469 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1909 st060837 51.5 µM -0.0379064262773836 0.484038507410196 no 1745 0.48488114465241 2493 678937
SGTC_3153 9100258 49.47 µM -0.0392913294687166 0.483453745125792 no 1746 0.484329059680783 2511 25236848
SGTC_1272 0839-0021 27 µM -0.0396936558397273 0.483283873233301 no 1747 0.484168679799527 2518 5027250
SGTC_2298 7976326 193.81 µM -0.0413183072141155 0.482597937441851 no 1748 0.483521069243021 2513 2235818
SGTC_512 prima-1 270 µM -0.041470110513366 0.48253384794305 no 1749 0.483460560351321 2543 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1715 st032160 10.2275 µM -0.0423341053803951 0.482169088507048 no 1750 0.483116178742577 2501 5289825
SGTC_3286 9117135 37.221 µM -0.0424696979422977 0.482111845687304 no 1751 0.483062133742938 2508 3438150
SGTC_3267 9137951 49.47 µM -0.0425524155429804 0.482076925157059 no 1752 0.48302916399946 2476 16643986
SGTC_1049 3226-0134 66 µM -0.0436929965733471 0.481595425153908 no 1753 0.482574560906037 2470 5702385
SGTC_2487 5918373 44.05 µM -0.0440436857720424 0.481447385928192 no 1754 0.482434790711909 2485 2876279
SGTC_816 0325-0417 81.3 µM -0.0440686417994298 0.481436851138769 no 1755 0.482424844354788 2514 68101
SGTC_2079 5212404 121 µM -0.0441158029634327 0.481416942840044 no 1756 0.482406048052531 2477 758462
SGTC_380 3970-0968 6 µM -0.0445115153104191 0.481249901303949 no 1757 0.482248336592541 2491 2891601
SGTC_2812 7970281 58.44 µM -0.0445941946541839 0.481215000395371 no 1758 0.48221538502656 2525 2233435
SGTC_953 1188-0045 9.7 µM -0.0446519385989876 0.48119062539446 no 1759 0.482192371449479 2532 6144426
SGTC_960 1222-0186 7.7 µM -0.044744947608208 0.481151364374933 no 1760 0.482155303271956 2532 3126296
SGTC_234 nsc-17383 10.7 µM -0.0453938829795985 0.48087744049014 no 1761 0.481896678319276 2500 408974
SGTC_3258 9138477 49.47 µM -0.0471009637739335 0.480156903397251 no 1762 0.481216379605682 2498 4970355
SGTC_2897 9048598 12.99 µM -0.0491987627145905 0.479271538175848 no 1763 0.480380448642508 2518 6467404
SGTC_1742 st038235 28.8875 µM -0.0493367241531226 0.479213315798656 no 1764 0.480325476749086 2567 564103 YBR002C RER2
SGTC_1768 st044301 37.178 µM -0.0499467671603205 0.478955871264891 no 1765 0.480082404490845 2520 3931349
SGTC_3192 9110362 49.47 µM -0.0501459981513525 0.478871795598134 no 1766 0.480003022299284 2489 16649480
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0504825413628639 0.478729776181691 no 1767 0.479868930819142 2512 115019
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0511267786154992 0.478457919091113 no 1768 0.479612248821419 2531 688788
SGTC_2960 9079389 5.97 µM -0.0512468674697929 0.478407244755115 no 1769 0.479564403021312 2511 16457355
SGTC_1211 1056-0033 32.3 µM -0.0523231102817003 0.477953114292527 no 1770 0.479135619597003 2519 6741922
SGTC_1244 0416-0015 52.5 µM -0.0531224835626568 0.477615829945381 no 1771 0.478817158725375 2522 96201
SGTC_990 3985-0011 41.3 µM -0.0538218351716281 0.477320761481003 no 1772 0.478538556390111 2556 5399565 YGL099W LSG1
SGTC_2786 7743617 45.45 µM -0.0540699609553631 0.47721607592776 no 1773 0.478439712454893 2524 583674
SGTC_1632 st005650 90 µM -0.0544174887706738 0.477069454787394 no 1774 0.478301272737583 2560 2759605
SGTC_2022 5136654 200 µM -0.0562606700430871 0.476291873454096 no 1775 0.477567074971134 2576 1713771
SGTC_636 0kpi-0074 126 µM -0.0562975636044886 0.476276310110039 no 1776 0.477552379860253 2560 616434
SGTC_3178 9107506 49.47 µM -0.0571075053033047 0.475934649860882 no 1777 0.477229778907466 2566 8897194
SGTC_3314 9135860 59.4275 µM -0.05739591734496 0.475812992362866 no 1778 0.47711490756488 2519 25252478
SGTC_750 4073-0104 132 µM -0.0578095985003594 0.475638497990444 no 1779 0.476950146234878 2512 22330957
SGTC_1010 4112-3296 15.2 µM -0.0586682214961146 0.475276338162644 no 1780 0.476608185647395 2521 704384
SGTC_2904 7225135 42.03 µM -0.0592194166353081 0.47504385951871 no 1781 0.476388672271572 2558 4446116
SGTC_2967 9089538 49.85 µM -0.0592286812549787 0.47503995203447 no 1782 0.476384982699316 2525 728216
SGTC_2543 pimpinellin 60.67 µM -0.0594790887242966 0.474934340057054 no 1783 0.476285260382591 2512 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2768 sulfasalazine 50.2 µM -0.0606329560650779 0.474447707271433 no 1784 0.475825763327391 2522 5384001 An antioxidant and salicylic acid derivative.
SGTC_2350 9023895 38.85 µM -0.0615385544585667 0.474065806261974 no 1785 0.475465155278454 2579 2997209
SGTC_730 1436-0052 41.2 µM -0.0616697754387966 0.474010470869929 no 1786 0.47541290492249 2509 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_459 nigericin 15.3 µM -0.0626323612131775 0.473604567481489 no 1787 0.47502962973778 2580 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_100 0086-0128 49.5915 µM -0.0639817500710166 0.473035603107823 no 1788 0.474492379181673 2516 93297
SGTC_2692 st077426 47.7 µM -0.0668991145947473 0.471805697666935 no 1789 0.473331008956101 2534 25238571
SGTC_2600 tangeritin 87.95 µM -0.0675800409315933 0.471518670326222 no 1790 0.473059972049492 2542 68077 A bioactive flavone.
SGTC_551 k048-0028 34.9 µM -0.0697631060805417 0.47059855468922 no 1791 0.472191106341967 2568 6836383
SGTC_1026 k007-1105 30.6 µM -0.0698256210729514 0.470572208234562 no 1792 0.472166227138644 2521 7066794
SGTC_2330 7979373 200 µM -0.0701654049923629 0.470429011214687 no 1793 0.472031004626388 2555 1863007
SGTC_1456 k015-0012 13 µM -0.0702979760466697 0.470373142096684 no 1794 0.471978246702261 2533 2989616
SGTC_1452 4194-0072 190 µM -0.0708909861535204 0.47012323834994 no 1795 0.471742258667333 2580 1343545
SGTC_641 4092-0595 30 µM -0.0718353600063281 0.469725288748117 no 1796 0.471366466141969 2566 786260
SGTC_1350 1495-0454 146 µM -0.072212841525315 0.469566230285973 no 1797 0.471216262898038 2608 1069057
SGTC_2950 9072895 21.46 µM -0.0734129635235745 0.469060570208609 no 1798 0.470738751015962 2585 17332245
SGTC_3020 9089140 49.47 µM -0.0734528292668691 0.469043774005772 no 1799 0.470722889708308 2581 17217859
SGTC_2721 ifenprodil 61.44 µM -0.0737598089139478 0.468914439435968 no 1800 0.470600753856207 2562 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2845 9003024 42.97 µM -0.073933780397622 0.468841144413223 no 1801 0.470531538261806 2671 2990173
SGTC_2413 inermin 26.06 µM -0.0741073506636427 0.468768019477775 no 1802 0.470462483181437 2730 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1447 4239-0816 81.9 µM -0.0741934916077994 0.468731728797057 no 1803 0.470428212262015 2544 1341554
SGTC_2110 5483698 200 µM -0.0756805305955022 0.468105289098015 no 1804 0.469836632948916 2589 2848765 YHR062C RPP1
SGTC_1864 st057645 30.4 µM -0.0759818279783236 0.467978372177392 no 1805 0.469716777785896 2549 688666
SGTC_1047 2043-3044 82 µM -0.0765593021362168 0.467735129116656 no 1806 0.469487068037934 2539 669592
SGTC_2226 7298446 200 µM -0.0770316023777922 0.467536196254276 no 1807 0.469299202294847 2552 3283010
SGTC_310 1273-0058 1.06 µM -0.0777423079589078 0.467236862357645 no 1808 0.469016519521057 2558 2734232
SGTC_587 k089-0003 57 µM -0.0789249186421124 0.466738813334038 no 1809 0.46854617142598 2540 9659696
SGTC_1797 st048695 56.8 µM -0.079264614865218 0.466595762007518 no 1810 0.468411075481248 2540 592262 YIL048W NEO1
SGTC_2947 9072639 7.68 µM -0.0805224814504877 0.46606609267593 no 1811 0.46791085833814 2609 16488146
SGTC_3046 9092212 49.47 µM -0.0814669139752078 0.465668445321679 no 1812 0.467535318107799 2535 25236637
SGTC_224 benfluorex 43.875 µM -0.0817371580367856 0.465554667054807 no 1813 0.467427864682559 2543 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2148 5546263 113.568 µM -0.0818079669224036 0.465524855533576 no 1814 0.467399710312442 2556 792097
SGTC_943 3253-1379 105 µM -0.0827440132221676 0.465130785328547 no 1815 0.467027543675747 2628 668464
SGTC_1799 st045822 46.1415 µM -0.0828901510339284 0.465069265211425 no 1816 0.466969442713593 2549 3674992
SGTC_652 0437-0092 114 µM -0.0837732490105623 0.464697522359611 no 1817 0.466618358716892 2558 3091274
SGTC_3 0833-0587 95.581 µM -0.0855694199707416 0.463941513991924 no 1818 0.465904354299152 2520 5382644
SGTC_2720 fluspirilene 36.88 µM -0.0859704411072933 0.463772741873779 no 1819 0.465744957393264 2626 3396 An atypical antipsychotic.
SGTC_2552 juarezic acid 87.02 µM -0.086007186924589 0.463757277504736 no 1820 0.46573035202964 2539 1549512
SGTC_2638 epoxomicin 18 µM -0.0867873498269313 0.46342896120404 no 1821 0.465420271528561 2655 9915668 A protesome inhibitor.
SGTC_488 nitrendipine 139 µM -0.0874727924168208 0.463140526641073 no 1822 0.465147855512417 2555 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2175 5807670 165.306 µM -0.0881682216999286 0.46284790947557 no 1823 0.464871487168742 2572 241186
SGTC_3179 9107801 49.47 µM -0.0881962308729705 0.46283612442008 no 1824 0.464860356486295 2586 4818259
SGTC_37 0566-0070 1.56 µM -0.0882576825066014 0.462810268329665 no 1825 0.464835936060885 2642 1626686
SGTC_631 k072-0230 41.5 µM -0.0884400727025168 0.462733527643801 no 1826 0.464763456324181 2652 5773147
SGTC_3330 9141424 71.43 µM -0.0891074344387153 0.462452746996871 no 1827 0.464498264536648 2653 27261020
SGTC_1590 st077108 57.8 µM -0.0926369271751509 0.460968089772621 no 1828 0.463096003114026 2544 5489485
SGTC_1239 0337-0584 35.4 µM -0.0927205413153464 0.460932924564002 no 1829 0.463062788849452 2664 914301 YML130C ERO1
SGTC_1318 1280-3875 124 µM -0.0944443486986353 0.460208019408007 no 1830 0.462378094026255 2622 373245
SGTC_2238 6671620 73.2395 µM -0.0949528616800972 0.459994201825552 no 1831 0.462176134303079 2546 729941
SGTC_593 1203-0218 61.7 µM -0.0954820728335781 0.459771693440904 no 1832 0.461965964502049 2643 3666956
SGTC_2907 7721985 69.9 µM -0.0956860984499067 0.45968591363209 no 1833 0.46188494103231 2617 3267881
SGTC_1591 genipin 88.4 µM -0.095838456326688 0.459621858048707 no 1834 0.461824437093639 2736 442424 A DNA cross-linking agent.
SGTC_2005 4024620 188 µM -0.0962653135711763 0.459442400713358 no 1835 0.461654929434533 2590 236743
SGTC_3028 9087778 49.47 µM -0.0964956768614135 0.459345555882192 no 1836 0.4615634536351 2596 17217395
SGTC_876 0720-0963 56.8 µM -0.0981989741630402 0.458629564167241 no 1837 0.46088714851397 2675 765861
SGTC_3126 9127922 49.47 µM -0.0984867528859275 0.458508607762664 no 1838 0.460772895242293 2803 45595682
SGTC_288 1315-0019 35.1 µM -0.0986287471432766 0.458448927507165 no 1839 0.460716522188963 2628 6811474
SGTC_3260 9137109 49.47 µM -0.0988473774638822 0.458357038908747 no 1840 0.460629725442999 2539 17478346
SGTC_3198 9112019 49.47 µM -0.101004058155763 0.457450723054355 no 1841 0.459773619355562 2590 45595555
SGTC_3044 9093193 49.47 µM -0.101226913249835 0.457357083750213 no 1842 0.459685166380824 2679 25236277
SGTC_1959 st077091 55.8 µM -0.101297542094687 0.457327407399883 no 1843 0.459657133641868 2567 821356 YKL052C ASK1
SGTC_1215 3852-0577 11.2 µM -0.102578372365259 0.456789278245445 no 1844 0.459148804313814 2726 2884876
SGTC_803 4488-1585 147 µM -0.102606437390902 0.456777487864405 no 1845 0.459137666755505 2628 747204
SGTC_2797 7859098 81.82 µM -0.102840735267829 0.456679058610054 no 1846 0.459044687288762 2621 972681
SGTC_3059 1327-0034 3 µM -0.103363952451722 0.456459263075564 no 1847 0.458837060319563 2623 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1085 doxorubicin 7.67 µM -0.105922847195527 0.455384503678466 no 1848 0.457821783299982 2612 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.106436231246573 0.455168916706265 no 1849 0.457618123977249 2711 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_844 0330-0132 15.3 µM -0.106876149881838 0.454984190797348 no 1850 0.457443617217747 2650 2828079
SGTC_715 0868-0130 184 µM -0.107432896258809 0.454750421797196 no 1851 0.457222779039811 2658 2876258
SGTC_1264 0783-0040 158 µM -0.108269298603797 0.454399259157573 no 1852 0.456891037795778 2586 2855798
SGTC_3100 9120536 49.47 µM -0.10881014206799 0.454172205557704 no 1853 0.456676539689243 2564 16421196
SGTC_1981 st071826 47 µM -0.109242032186913 0.453990902836194 no 1854 0.456505261458121 2681 11838600
SGTC_937 3122-0005 46.7 µM -0.110348373314556 0.453526516821626 no 1855 0.456066547558496 2652 759535
SGTC_1441 4106-0040 13 µM -0.110486740374372 0.453468441789777 no 1856 0.456011682567665 2596 2904180
SGTC_979 1426-2828 121 µM -0.112425355901137 0.452654876749767 no 1857 0.455243075834718 2698 747872
SGTC_720 r052-1644 49.9 µM -0.113748341860096 0.452099782480478 no 1858 0.454718644959107 2698 1422863 YOR257W CDC31
SGTC_753 1322-0200 289 µM -0.114355071895568 0.451845243856648 no 1859 0.454478163860171 2732 5403907
SGTC_984 1492-0255 2.91 µM -0.114609243553102 0.451738618282772 no 1860 0.454377426348678 2746 1585198
SGTC_2549 cedrol 20.94 µM -0.114724686077427 0.45169019103708 no 1861 0.454331673228452 2619 6708665 A sedative which affects the nervous system.
SGTC_3036 9090181 49.47 µM -0.116466556726829 0.450959577439984 no 1862 0.453641394777148 2602 25236586
SGTC_1646 st011709 75.6 µM -0.117546395997548 0.450506730819862 no 1863 0.453213540079376 2618 5757843
SGTC_3160 9100216 49.47 µM -0.118070169983592 0.450287101594116 no 1864 0.453006029499301 2582 17191039
SGTC_2166 5933061 31.504 µM -0.118835009962702 0.449966415794111 no 1865 0.452703035630889 3073 2877375
SGTC_2949 9072542 2.23 µM -0.121065308754686 0.449031472628615 no 1866 0.451819653311164 2702 16457352
SGTC_894 0960-0238 55.9 µM -0.121270012352242 0.448945674802762 no 1867 0.451738585682234 2596 6741907 YDL195W SEC31
SGTC_2880 9042983 58.44 µM -0.12186093103174 0.448698015288559 no 1868 0.451504578740533 2754 6464714
SGTC_1880 MG-132 525 µM -0.122103850136836 0.448596211424756 no 1869 0.451408386364853 2670 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_676 falcarinol 140 µM -0.122273823757724 0.448524979964768 no 1870 0.451341081019219 2658 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1663 st014140 55.4 µM -0.123032091959766 0.448207230012832 no 1871 0.451040842650734 2624 4207120
SGTC_2207 7258803 200 µM -0.123684165689108 0.447934007091824 no 1872 0.450782674667018 2677 3666799
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.124276136310498 0.447685989130414 no 1873 0.450548320636925 2626 16486 A toxic proline analog.
SGTC_2837 9008476 45.46 µM -0.124341232723692 0.447658716929287 no 1874 0.45052255080267 2819 2992805
SGTC_2933 9026794 32.47 µM -0.124607351957834 0.447547228610495 no 1875 0.450417203872955 2674 17586027
SGTC_2269 7935389 174.42 µM -0.125194582107421 0.44730122836422 no 1876 0.450184753175749 2615 97605
SGTC_2970 9090938 41.86 µM -0.125433223480843 0.447201263405124 no 1877 0.45009029363782 2684 17217104
SGTC_1383 3049-0032 20.7 µM -0.125833068372217 0.447033779105306 no 1878 0.449932032519437 2752 712864
SGTC_2997 9067075 71.4286 µM -0.126038421142377 0.446947766007572 no 1879 0.449850755696969 2710 27209819
SGTC_1089 terbinafine 2.25 µM -0.127711804010398 0.446246954087061 no 1880 0.449188524171676 2746 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_231 b-estradiol 524 µM -0.128909125382449 0.445745619386787 no 1881 0.448714777954677 2640 450 A steroid.
SGTC_1242 0402-0103 60.1 µM -0.129276610920825 0.445591765565487 no 1882 0.448569388949645 2644 432868
SGTC_1991 st073000 8.92 µM -0.130383662904838 0.445128329786717 no 1883 0.448131445682319 2837 4301969 YIL048W NEO1
SGTC_2596 sinensetin 100 µM -0.130633245724869 0.445023859383771 no 1884 0.448032720896269 2688 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1494 4358-1428 177 µM -0.132468596167769 0.444255735944723 no 1885 0.447306830360861 2735 1564571
SGTC_1867 st057372 64 µM -0.132848800458895 0.444096640461986 no 1886 0.447156479593652 2637 688837
SGTC_2900 5328528 85.29 µM -0.134025067956421 0.443604491586541 no 1887 0.446691375950643 2625 795359
SGTC_1294 1000-1494 117 µM -0.13408178850746 0.443580761969652 no 1888 0.446668950132225 2661 712797 YDL207W GLE1
SGTC_1147 3809-1045 12.3 µM -0.134252727197124 0.443509249261781 no 1889 0.446601366488888 2665 325925
SGTC_996 3970-0799 1.8 µM -0.134678586616137 0.443331097716477 no 1890 0.44643300216223 2718 6615648 YGL040C HEM2
SGTC_3193 9111931 49.47 µM -0.135085669558094 0.443160811720142 no 1891 0.446272070177754 2659 17087244
SGTC_2096 5468907 200 µM -0.138511867445461 0.441728025203382 no 1892 0.444917945577603 2785 759785
SGTC_644 1498-1197 63.3 µM -0.138661221498996 0.441665584693395 no 1893 0.444858931380949 2743 6741615
SGTC_802 4112-3352 742 µM -0.138754936668089 0.441626405894568 no 1894 0.444821902374375 2796 704594
SGTC_2828 7998861 71.43 µM -0.139381795229274 0.441364354536357 no 1895 0.444574228618291 2693 2988188
SGTC_2048 5246248 200 µM -0.139645687925603 0.441254044754289 no 1896 0.444469970264566 2681 677046
SGTC_895 0964-0006 13.7 µM -0.139835062752958 0.44117488699358 no 1897 0.444395154692674 2619 6738897
SGTC_2864 9034755 47.6 µM -0.140186053920475 0.441028180601635 no 1898 0.444256495226596 2637 4930451
SGTC_3336 9143619 71.43 µM -0.140266361571902 0.44099461495142 no 1899 0.444224770554625 2642 45595730
SGTC_2779 methotrexate 400 µM -0.140704854028794 0.440811348683369 no 1900 0.444051555144438 2642 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1303 1160-0052 261 µM -0.140903229089213 0.440728442737368 no 1901 0.443973195578044 2663 3562476
SGTC_3293 9120939 62.045 µM -0.141825777214028 0.440342920775725 no 1902 0.443608811302419 2788 934087
SGTC_1276 0871-0068 94.2 µM -0.142572494270749 0.440030917929972 no 1903 0.443313910956887 2759 3414906
SGTC_1173 0443-0020 122 µM -0.143286829733729 0.439732480021008 no 1904 0.443031828426255 2689 5331295
SGTC_2387 9077560 195.08 µM -0.143347341743257 0.439707200644073 no 1905 0.443007934281896 2640 5303272
SGTC_2284 7945075 39.21 µM -0.144240553267408 0.439334083021204 no 1906 0.442655259439334 2789 1245402
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.144995836438472 0.439018623685194 no 1907 0.442357079546284 2627 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2403 6032726 181.2 µM -0.14535123679973 0.438870196902974 no 1908 0.442216781548509 2728 2881040
SGTC_2017 5132927 60.65 µM -0.145460243797754 0.43882467374693 no 1909 0.442173751351129 2682 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_600 1495-0418 41.6 µM -0.14753681936103 0.437957616083925 no 1910 0.441354160025012 2680 5377768
SGTC_2792 7535235 81.82 µM -0.148838665303834 0.43741419222405 no 1911 0.440840469965506 2744 1281891
SGTC_2076 5212012 200 µM -0.149192819480718 0.437266379575367 no 1912 0.440700742903565 2622 604802
SGTC_1705 st027868 56.3335 µM -0.149628274479684 0.4370846465623 no 1913 0.440528949749175 2750 292948
SGTC_325 2810-4341 181 µM -0.149674429508175 0.437065384976418 no 1914 0.440510741593315 2788 774970
SGTC_608 k048-0125 159 µM -0.150287239341558 0.436809659084564 no 1915 0.440269000089044 2745 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2073 5212005 126 µM -0.151395474504031 0.436347259043306 no 1916 0.439831879569898 2647 691789
SGTC_2133 5320837 200 µM -0.153016386381055 0.435671106570845 no 1917 0.439192676501927 2810 2841355
SGTC_1006 4099-6547 255 µM -0.153053852259274 0.43565548014749 no 1918 0.439177903782506 2775 3146833
SGTC_1295 1013-0063 9.78 µM -0.154167426699937 0.435191071889551 no 1919 0.438738862415205 2724 6826038
SGTC_2481 5478948 45.16 µM -0.154868821390019 0.434898606086996 no 1920 0.438462366986343 2804 77792
SGTC_1863 st057641 20.1 µM -0.155033498981349 0.434829944393978 no 1921 0.438397454103623 2677 3921635
SGTC_1386 3228-0095 33.8 µM -0.155604802956232 0.434591756631719 no 1922 0.438172269425429 2803 870181
SGTC_2989 9073649 71.4286 µM -0.155994653380758 0.434429234012614 no 1923 0.438018617807011 2661 21367202
SGTC_413 propylparaben 100 µM -0.156362184289215 0.434276026201987 no 1924 0.437873771528507 2667 7175 A pharmaceutical preservative.
SGTC_2493 resveratrol 26.09 µM -0.157027781088099 0.433998592696583 no 1925 0.43761147677885 2657 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1782 st039423 80.636 µM -0.157091554605687 0.433972012376374 no 1926 0.437586346696806 2728 2068169
SGTC_2305 7443522 69.23 µM -0.157104502081164 0.433966616002891 no 1927 0.437581244748963 2698 5415886
SGTC_1989 st071868 50.2 µM -0.157210784259212 0.433922319158724 no 1928 0.437539364688986 2815 16414057
SGTC_2879 9041815 71.43 µM -0.159141155996533 0.433117913642897 no 1929 0.436778831790325 2685 4942971
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.160419414749924 0.432585402480706 no 1930 0.436275348455707 2688 16623 A steroid.
SGTC_401 neomycin 50 µM -0.161507253556372 0.432132314947362 no 1931 0.435846949422466 2726 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1198 1612-1005 86.7 µM -0.164625935937037 0.430833872761256 no 1932 0.434619207908709 2883 6998509
SGTC_1508 1080-0625 72.9 µM -0.165097243575343 0.430637711690481 no 1933 0.434433721274515 2671 767111
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.165248425208055 0.430574792609444 no 1934 0.434374225671385 2832 5282362
SGTC_1220 1838-0075 193 µM -0.165633904433225 0.430414371056773 no 1935 0.43422253196895 2722 5529645
SGTC_2906 7926292 26.41 µM -0.166540240000132 0.430037234516979 no 1936 0.433865909184808 2830 2966319
SGTC_1716 st033144 30.6155 µM -0.168715954853745 0.429132155950488 no 1937 0.433010034265274 2795 674617
SGTC_1883 5-benzylidenerhodanine 20 µM -0.169844629718584 0.428662783388174 no 1938 0.432566163680528 2798 1273210
SGTC_318 1488-0629 67.2 µM -0.17068672985016 0.42831265193293 no 1939 0.432235048873081 2794 3662576
SGTC_219 mitoxanthrone 164.414 µM -0.171279057305149 0.428066405655649 no 1940 0.432002173485547 2779 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1682 st012968 530 nM -0.173204396557922 0.427266184898158 no 1941 0.431245383960089 2733 24207270
SGTC_1687 st020778 55.3625 µM -0.174110392717517 0.42688973278855 no 1942 0.430889352871176 2731 4259299
SGTC_2342 7990637 118.86 µM -0.175030967565518 0.426507291256904 no 1943 0.430527650287862 2824 2033102 YER133W GLC7
SGTC_1078 idebenone 36.1 µM -0.175872797793027 0.42615762368049 no 1944 0.430196938216928 2790 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2228 7354201 200 µM -0.176232526484293 0.426008222331404 no 1945 0.430055634117203 2732 753451
SGTC_2015 5119600 184 µM -0.176698716705743 0.425814621528294 no 1946 0.429872524467595 2880 2828786
SGTC_495 decylubiquinone 155 µM -0.1768392228573 0.42575627523812 no 1947 0.429817339582072 2777 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2071 5230951 39.92 µM -0.177456020161087 0.425500164528687 no 1948 0.429575103871563 2737 1799272
SGTC_2279 7948423 32.93 µM -0.17841177831849 0.425103370345467 no 1949 0.429199799970236 2779 1247112
SGTC_65 0798-0905 34.986 µM -0.178690221673988 0.424987785580133 no 1950 0.429090473791284 3128 3602145
SGTC_2157 5649910 96.377 µM -0.179526316162426 0.42464075275487 no 1951 0.428762227838395 2743 2858091
SGTC_3037 9091026 49.47 µM -0.179556500346857 0.424628225473537 no 1952 0.428750378618889 2787 25236398 YIL048W NEO1
SGTC_853 0419-0306 21 µM -0.181052643105766 0.424007380012902 no 1953 0.428163127758692 2723 762713
SGTC_1821 st053465 65.6 µM -0.181213684924254 0.423940564660362 no 1954 0.428099926707891 2812 675086
SGTC_2197 6588183 93.1375 µM -0.182483443541878 0.423413825619708 no 1955 0.427601673175727 2741 884136
SGTC_2893 9048488 25.97 µM -0.182892236910267 0.423244273307926 no 1956 0.427441287104617 2744 6467338
SGTC_244 nsc-207895 1.295 µM -0.183666033353045 0.422923370213591 no 1957 0.427137728506261 2704 42640
SGTC_2855 9016525 58.44 µM -0.184041375143581 0.422767729668128 no 1958 0.426990498295537 2717 43811474
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.18412846275032 0.422731619337328 no 1959 0.426956339079333 2729 4174840
SGTC_1043 0916-0009 19.3 µM -0.184672094003002 0.422506220730882 no 1960 0.426743117714779 2832 3101130
SGTC_435 c-PAF 6.7 µM -0.185515000606318 0.42215678775486 no 1961 0.426412557846123 2869 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_14 0354-0009 295 µM -0.185595962782002 0.42212322752507 no 1962 0.426380809897057 2691 1713507
SGTC_633 0437-0093 97.7 µM -0.185708740275104 0.422076480235403 no 1963 0.426336586904015 2719 2831118
SGTC_2972 9093619 59.92 µM -0.18576831591936 0.422051786035786 no 1964 0.426313226115709 2755 25236256
SGTC_863 0466-0191 129 µM -0.185804916632228 0.422036615133855 no 1965 0.426298874380566 2812 765160 YPR165W RHO1
SGTC_3171 9103192 49.47 µM -0.186247704599282 0.421853089825251 no 1966 0.426125257750911 2758 13018434
SGTC_1320 1313-0481 95.3 µM -0.186653342968524 0.42168497705387 no 1967 0.425966219998944 2850 6813365 YLR208W SEC13
SGTC_1881 5652484 16 µM -0.18881020298564 0.420791328376148 no 1968 0.425120787425372 2855 2255129
SGTC_2097 5376186 200 µM -0.189382778499858 0.42055416234057 no 1969 0.424896410499717 2844 742755
SGTC_450 aminopyrene 156 nM -0.190238207172039 0.420199889677067 no 1970 0.424561236385722 2795 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2391 6285546 200 µM -0.190727862075319 0.419997129958271 no 1971 0.424369404301528 2717 846083
SGTC_1008 4106-0037 6 µM -0.190971713225103 0.419896162289324 no 1972 0.42427387742467 2719 2905394
SGTC_1162 k048-0130 20.1 µM -0.191264772543518 0.419774826732212 no 1973 0.424159079499255 2748 6797406
SGTC_2030 5175110 200 µM -0.192209645953021 0.419383672113419 no 1974 0.423788995201085 2874 2831986
SGTC_3170 9103054 49.47 µM -0.192510231163126 0.419259253826406 no 1975 0.423671277244488 2804 16432970
SGTC_972 1319-0219 195 µM -0.194179032211165 0.418568650539159 no 1976 0.423017850131162 2825 23903702
SGTC_309 k408-0051 1.48 µM -0.194643772121007 0.418376370866061 no 1977 0.422835916587275 2788 3640463
SGTC_13 0199-0087 65 µM -0.195845217915958 0.41787937987146 no 1978 0.422365658275993 2746 4589825
SGTC_1188 1403-0014 4.57 µM -0.196241460407505 0.417715498610727 no 1979 0.422210589095776 2787 9614867
SGTC_773 4358-1457 44.6 µM -0.196713869617156 0.417520134361525 no 1980 0.422025727890637 2802 1186886
SGTC_528 3492-0019 172 µM -0.19685550647675 0.417461564576543 no 1981 0.421970306489874 2779 2869262
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.19792421695804 0.4170196897076 no 1982 0.421552178289357 2814 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1941 st076221 61.8 µM -0.198404045519304 0.416821331227918 no 1983 0.421364476247432 2922 2828568
SGTC_3201 9113999 49.47 µM -0.198737042105472 0.416683684720052 no 1984 0.421234223266045 2958 16649224
SGTC_604 1000-0114 314 µM -0.198764800147624 0.416672211196846 no 1985 0.421223365982948 2913 1572745
SGTC_334 1502-1024 68.5 µM -0.199269062537756 0.416463791492443 no 1986 0.421026139183046 2854 3296216
SGTC_1745 st081495 74 µM -0.199700088709228 0.416285660100438 no 1987 0.420857572195609 2765 13842402 YBL026W LSM2
SGTC_2656 pseudo-anisatin 100 µM -0.201273677658551 0.415635484818053 no 1988 0.420242291784381 2771 6708809 A neurotoxin.
SGTC_2811 7967822 32.47 µM -0.201785037198331 0.415424250968651 no 1989 0.420042389761977 2898 2232244
SGTC_2984 9022109 38.96 µM -0.202283467677468 0.415218381412878 no 1990 0.419847561851829 2815 6459207
SGTC_2025 5147754 141 µM -0.202380138841695 0.415178455469082 no 1991 0.419809777027591 2857 315777 YLR208W SEC13
SGTC_2882 9058044 58.44 µM -0.202967352549429 0.414935950468591 no 1992 0.41958027498017 2864 18076804
SGTC_3255 9139072 49.47 µM -0.203091232910741 0.414884795024604 no 1993 0.419531862032536 2837 17646060
SGTC_189 3970-0742 2.116 µM -0.204022703889856 0.414500197518048 no 1994 0.419167878456076 2783 2891807
SGTC_369 0957-0393 4.5 µM -0.204248131739263 0.414407132322588 no 1995 0.419079800174728 2838 6997992
SGTC_76 0433-0009 400.328 µM -0.204924419859003 0.414127963699607 no 1996 0.418815587893846 2905 2841569
SGTC_365 0121-0052 13.6 µM -0.205319314447541 0.413964973083864 no 1997 0.418661327377892 2911 3101739
SGTC_3285 9112818 20.8695 µM -0.205588597840579 0.413853836309136 no 1998 0.418556142438264 2751 17017947 YPR165W RHO1
SGTC_2690 usnic acid 100 µM -0.206664212394206 0.413409985033228 no 1999 0.418136054179883 2967 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_991 3996-0057 64.7 µM -0.207439843627129 0.413089990194231 no 2000 0.417833184272852 2862 715343
SGTC_1658 st012944 20 µM -0.208523068180544 0.412643191147124 no 2001 0.417410286344244 2826 24207260
SGTC_1779 st039427 55 µM -0.209691858888998 0.412161225452691 no 2002 0.416954089972105 2859 1124498
SGTC_2014 4013930 200 µM -0.211822439912639 0.411282994570396 no 2003 0.416122780611561 2800 64556
SGTC_1688 st021091 57.6 µM -0.212566681802104 0.410976320685943 no 2004 0.415832480782797 2827 3656366
SGTC_1118 chelidonine 707.474 nM -0.212704450286739 0.41091955747516 no 2005 0.415778747685277 2869 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_375 3970-0961 9.27 µM -0.213007251631514 0.410794804174231 no 2006 0.415660653248129 2829 2898222
SGTC_1570 verbenone 133 µM -0.213316674953321 0.410667331958703 no 2007 0.415539984066579 2957 29025 A natural terpanoid with antifungal properties.
SGTC_489 paxilline 115 µM -0.214296708116301 0.41026365290823 no 2008 0.415157842478712 2847 105008 A toxic potassium channel blocker.
SGTC_418 lividomycin a 100 µM -0.215208124214712 0.409888322766833 no 2009 0.414802528560383 2832 72394 An antibiotic.
SGTC_2546 rhodinyl acetate 100 µM -0.215225106056716 0.409881330259087 no 2010 0.414795908880407 2803 6708682
SGTC_2143 5623677 140.463 µM -0.215289400637283 0.409854856338141 no 2011 0.414770846474062 2772 5375313
SGTC_1556 plumbagin 1.48 µM -0.215962919018399 0.409577553294463 no 2012 0.414508325910647 2774 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1362 1611-0397 101 µM -0.216386232928097 0.409403288337723 no 2013 0.414343348304699 2809 27816
SGTC_1832 st054113 55 µM -0.216969232996273 0.409163314945525 no 2014 0.414116161152551 2853 1251267
SGTC_1056 3448-1962 115 µM -0.217768915974241 0.408834206324553 no 2015 0.413804582389944 2894 715507
SGTC_563 tetrahydrosecaminediol 614 µM -0.218461266242963 0.408549322256252 no 2016 0.413534867254663 2945 334274 A psychoactive constituent of the cannabis plant.
SGTC_2327 6189656 200 µM -0.218613817515254 0.408486557879502 no 2017 0.413475444163643 2913 5349088
SGTC_2234 tolnaftate 200 µM -0.21893354619782 0.408355019091398 no 2018 0.413350907112649 2824 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2271 7849410 118.62 µM -0.219321415196994 0.408195460725739 no 2019 0.413199840529739 2769 972430
SGTC_1505 k297-0037 20.6 µM -0.22025790009771 0.407810280042053 no 2020 0.412835152934415 2801 4089396
SGTC_1539 benzyladenosine 56 µM -0.220376525549819 0.407761495180395 no 2021 0.412788962963384 2790 92208 A nucleotide analog.
SGTC_389 tpck 16.7 µM -0.221453653689584 0.407318590462108 no 2022 0.412369609844467 2868 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1749 st037932 54.2 µM -0.2214973627737 0.407300620205033 no 2023 0.412352594905493 2932 594497
SGTC_308 4092-1169 104 µM -0.221544784572886 0.407281123748075 no 2024 0.41233413487843 2820 2268590 YDL196W YDL196W
SGTC_910 3454-3003 490 µM -0.222392222659217 0.406932756504809 no 2025 0.412004282831214 2889 820824
SGTC_2089 5281248 129.67 µM -0.223775765419116 0.406364164168531 no 2026 0.411465894092123 2813 2737878
SGTC_1183 1254-0324 198 µM -0.223861786791736 0.406328818609488 no 2027 0.411432425420413 2936 5799357
SGTC_3033 9090887 49.47 µM -0.224028929949552 0.406260142879082 no 2028 0.411367396221599 2808 19325384
SGTC_2833 9001315 45.46 µM -0.22426148415411 0.406164595875376 no 2029 0.411276922063553 2823 2989378
SGTC_2892 9047358 58.44 µM -0.224585802760039 0.406031355967076 no 2030 0.411150755261029 2861 6466771
SGTC_1352 1496-0991 99 µM -0.225936812382124 0.405476437548498 no 2031 0.410625282935195 2788 3000039
SGTC_3162 9099653 49.47 µM -0.226072401807505 0.405420755542851 no 2032 0.410572554556098 2841 25237511
SGTC_2544 sphondin 68.51 µM -0.226113539609188 0.405403862013061 no 2033 0.410556557097071 3032 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2031 5180455 200 µM -0.228502619507751 0.404423072702168 no 2034 0.409627759957321 2807 29949
SGTC_232 clozapine 119 µM -0.228619850714682 0.404374961160032 no 2035 0.409582197254576 2788 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_534 k292-0788 63.4 µM -0.228643124983382 0.404365409601001 no 2036 0.40957315169764 2885 4146317
SGTC_582 0987-0078 156 µM -0.232783848536819 0.402667004692749 no 2037 0.407964627714457 2842 1625765
SGTC_2966 9084041 48.03 µM -0.234585169693669 0.401928725859413 no 2038 0.407265360629696 2766 17741380
SGTC_453 enantio-paf c16 10 µM -0.236364529709235 0.401199791290612 no 2039 0.406574908822334 2929 13871343 A lipid and platelet activating factor
SGTC_3223 9129970 49.47 µM -0.237059609349116 0.40091513743496 no 2040 0.40630527318005 2812 17248386
SGTC_1979 st071809 45.3 µM -0.237145981994173 0.400879769178785 no 2041 0.406271770561006 2968 4976333
SGTC_1059 3448-6867 171 µM -0.237513990994744 0.400729084319376 no 2042 0.406129033229844 2784 3934407
SGTC_1750 st081859 2.357 µM -0.240318981113202 0.399581040762711 no 2043 0.405041490657542 2865 5291695
SGTC_3145 9085516 49.47 µM -0.240549706791291 0.39948664642965 no 2044 0.404952066882049 2923 25236195
SGTC_1911 st060208 74.3 µM -0.241029961402225 0.399290183837097 no 2045 0.404765947559269 2940 688783
SGTC_677 0929-0063 136 µM -0.241130471505035 0.399249070382252 no 2046 0.404726998295159 2826 1539583
SGTC_2362 9071156 126 µM -0.241758040781017 0.398992389723979 no 2047 0.404483826577256 3011 653133
SGTC_514 4466-0038 2.65 nM -0.243052787134996 0.398462966621289 no 2048 0.403982252504956 2871 5722064
SGTC_2400 5203494 178.7 µM -0.243528399697387 0.398268535027151 no 2049 0.403798043708105 2785 6777674
SGTC_1509 1326-1131 80 µM -0.244492206551872 0.397874605887344 no 2050 0.403424818567191 2887 768313
SGTC_339 3091-4833 71.4 µM -0.245936169422462 0.397284621295536 no 2051 0.402865822189931 2852 3240077
SGTC_1708 st033234 31.827 µM -0.247379568754991 0.396695101746601 no 2052 0.402307242333927 2972 674664
SGTC_382 3229-0966 23.2 µM -0.247629618722873 0.396592999181172 no 2053 0.40221049594845 3012 5722370
SGTC_1130 3454-2858 15.9 µM -0.248718218066 0.396148575592892 no 2054 0.401789377806652 2948 715628 YIL048W NEO1
SGTC_2111 5486399 200 µM -0.249899235845967 0.39566657454739 no 2055 0.401332637093446 2846 689674
SGTC_978 1416-0512 87.4 µM -0.251126427143632 0.395165898007369 no 2056 0.40085818226847 2920 6814003
SGTC_1347 1493-0251 600 nM -0.251283331282387 0.395101895815844 no 2057 0.400797530756903 2977 3986378
SGTC_1346 1488-2224 62.4 µM -0.253012504044286 0.39439674311277 no 2058 0.400129275337548 2929 3722427
SGTC_2806 7952793 58.44 µM -0.255204188511044 0.393503476540154 no 2059 0.399282698097472 3015 2972490
SGTC_3154 9100113 49.47 µM -0.255866082912846 0.393233817642028 no 2060 0.399027122466809 2883 25237525
SGTC_220 paclitaxel 373.376 µM -0.257784427470756 0.392452564777504 no 2061 0.398286641743478 2972 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3073 9114972 49.47 µM -0.258319313078445 0.39223480775082 no 2062 0.398080241135668 2985 41905075
SGTC_1572 epiandrosterone 68.9 µM -0.258383021256114 0.392208873792235 no 2063 0.398055659448638 2839 441302 A steroid.
SGTC_2731 amoxapine 43.43 µM -0.259197786613612 0.39187724604976 no 2064 0.39774131939563 2886 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_404 fumagillin 50 µM -0.259801355348433 0.391631630687351 no 2065 0.397508502714721 2914 12015870 A methionine aminopeptidase binder.
SGTC_1126 isoteolin 1.0172 µM -0.259883353048158 0.391598265995886 no 2066 0.397476876269751 2856 133323
SGTC_1830 st055982 50.3 µM -0.260081421466204 0.391517675663233 no 2067 0.397400484225255 2932 455313 An antimicrobial agent.
SGTC_2533 agelasine 13.65 µM -0.260105040679802 0.391508065757874 no 2068 0.39739137490823 3056 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3355 9151058 44.0485 µM -0.260294435591498 0.391431009398252 no 2069 0.397318332235482 2858 17015728
SGTC_509 pifithrin 175 µM -0.260950724420605 0.39116402766249 no 2070 0.397065253571361 2931 4817 A p53 inhibitor.
SGTC_2120 5538279 151.968 µM -0.261308747888652 0.391018403447064 no 2071 0.396927210516296 2906 2058197
SGTC_1224 0823-0416 294 µM -0.262115993644661 0.39069011645392 no 2072 0.396616008300863 3001 3598164
SGTC_1877 wortmannin 25 µM -0.262170005303202 0.390668154018765 no 2073 0.396595188553834 3003 312145 A covalent inhibitor of PI 3-kinase.
SGTC_537 1334-0398 209 µM -0.262474980000789 0.390544150542471 no 2074 0.396477636207799 3044 5846986
SGTC_2674 ligustilide 100 µM -0.263351907314702 0.390187651765618 no 2075 0.39613967747149 2961 5319022 A signalling regulator.
SGTC_1986 st071812 45 µM -0.26423149039474 0.389830166079855 no 2076 0.395800773624777 2902 11838594
SGTC_2280 7785178 200 µM -0.264360047346231 0.389777924952389 no 2077 0.395751247151126 2887 2954328
SGTC_1838 st055369 84.5 µM -0.266572828096642 0.388879039747641 no 2078 0.394899039410571 2858 676036
SGTC_393 acivicin 6.25 µM -0.266574131604916 0.388878510405721 no 2079 0.394898537538455 2875 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1686 st019653 115.5 µM -0.266878118084975 0.388755070114479 no 2080 0.394781502510138 3014 97252
SGTC_2645 abamectin 100 µM -0.267183950730493 0.388630891481389 no 2081 0.394663766287745 3004 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2339 9000433 200 µM -0.269687121432329 0.387614946411131 no 2082 0.393700484586174 2937 2988954
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.269905354047531 0.387526410151493 no 2083 0.393616534031044 3059 1273210
SGTC_1612 st002233 45.4 µM -0.270119550139557 0.387439517183501 no 2084 0.39353414106941 2889 1035021
SGTC_169 k015-0017 16.025 µM -0.270424164004005 0.387315954133109 no 2085 0.393416976094782 3100 1840002
SGTC_1033 k072-0102 21.3 µM -0.271052286162646 0.387061199778779 no 2086 0.39317540917724 3064 5965931
SGTC_1962 st076595 64.5 µM -0.272342527364157 0.386538055270955 no 2087 0.392679329715049 2879 279619
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.272940758415002 0.386295564863934 no 2088 0.39244937744353 2943 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_994 3910-0338 138 µM -0.274244545509768 0.385767234281826 no 2089 0.391948348740993 3076 3479481
SGTC_3346 9158254 43.5805 µM -0.274882634797266 0.385508740006247 no 2090 0.391703204422744 2976 17639500
SGTC_1142 3253-1408 9.78 µM -0.275027176384727 0.385450192293505 no 2091 0.391647679685665 2902 256655
SGTC_2748 diazoxide 86.69 µM -0.275395745753905 0.385300912173805 no 2092 0.391506106084879 2969 3019 A potassium channel activatior.
SGTC_2479 5617353 43.85 µM -0.275886856172209 0.38510202617317 no 2093 0.391317484769808 3043 2731746
SGTC_2361 9034121 116 µM -0.277567532718 0.384421628095457 no 2094 0.390672179116788 2925 6496917
SGTC_2752 diclazuril 33.15 µM -0.27871314125984 0.383958048571915 no 2095 0.390232488364014 3043 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3274 9138298 49.47 µM -0.279537327888672 0.383624637584049 no 2096 0.389916247867837 2882 17015756
SGTC_553 k007-0256 45.7 µM -0.280639309796916 0.383178983765308 no 2097 0.389493531148963 2947 6287000
SGTC_3099 9120367 49.47 µM -0.280661382790105 0.383170058776793 no 2098 0.389485065353416 2891 24824940
SGTC_613 3914-0030 117 µM -0.281572925744699 0.382801539938781 no 2099 0.389135501331663 2833 1145395
SGTC_1028 k015-0029 4.8 µM -0.281940555792211 0.382652944359474 no 2100 0.388994545701951 2885 4588309
SGTC_1905 st060207 84.5 µM -0.282663275075893 0.382360872556477 no 2101 0.388717485410326 2854 1948547
SGTC_283 0987-0079 11.7 µM -0.283253697537089 0.382122315386217 no 2102 0.388491184173615 2995 411556
SGTC_1176 0848-0131 83.3 µM -0.284129495533347 0.381768536125731 no 2103 0.388155571934627 3000 6769040
SGTC_3315 9136395 68.55 µM -0.284380365580017 0.381667215159008 no 2104 0.388059452061174 3083 16876844
SGTC_1910 st062352 60.4 µM -0.286556685269707 0.380788587790064 no 2105 0.38722589208266 2860 2245730
SGTC_1674 st016616 23.6 µM -0.287750459853914 0.380306895797041 no 2106 0.386768880694085 2853 625830
SGTC_2356 9061756 188.97 µM -0.287854826855731 0.380264792176467 no 2107 0.386728933443975 2980 20104043
SGTC_245 methotrexate 289.6 µM -0.288648836965051 0.379944519981428 no 2108 0.386425059463753 2998 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_469 w7 172 µM -0.289500598543316 0.379601044655141 no 2109 0.386099160960616 2938 45115570 A P450 inhibitor.
SGTC_2371 9071574 200 µM -0.289544046709057 0.379583526600212 no 2110 0.386082539103642 3029 45596039
SGTC_2058 5236698 133 µM -0.290832888571984 0.379063985405216 no 2111 0.385589565296319 2948 766665
SGTC_574 1315-0397 40 µM -0.291420831625928 0.378827053914834 no 2112 0.385364742139056 2909 6794277
SGTC_1622 st003707 19.4 µM -0.292161079258799 0.378528810911101 no 2113 0.385081734119668 3046 10140899
SGTC_2423 st077119 87.2 µM -0.292383116396919 0.378439367073238 no 2114 0.384996857842615 2899 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_32 0928-0142 34.1 µM -0.293008764971322 0.378187370361826 no 2115 0.384757726051847 3001 2244242
SGTC_2364 9055074 200 µM -0.293054501842051 0.378168950643683 no 2116 0.384740246487105 3006 6470630
SGTC_352 k048-0007 5.11 µM -0.29366799040937 0.377921905724769 no 2117 0.384505808133035 3015 6811911
SGTC_1090 efavirenz 20.7 µM -0.293904226857541 0.377826789280435 no 2118 0.384415544059153 2966 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2945 9067681 61.76 µM -0.296400795059082 0.376822043867615 no 2119 0.383462009112027 2886 16456930
SGTC_1062 mesoridazine 14.2 µM -0.297664252545343 0.376313881890898 no 2120 0.382979714804271 2913 4078 A neuroleptic.
SGTC_2755 lomerizine 42.69 µM -0.29786654275331 0.376232540750874 no 2121 0.382902512238743 2960 3949 A calcium channel blocker.
SGTC_385 1494-0393 12.4 µM -0.300664920140026 0.375107875249996 no 2122 0.381835010681197 2974 3090647
SGTC_1275 0867-0008 21.1 µM -0.300845518762711 0.375035329162061 no 2123 0.381766148190399 2898 3422836
SGTC_659 k018-0002 107 µM -0.301660581658194 0.374707975138652 no 2124 0.381455410218136 3069 6797879 YHR007C ERG11
SGTC_3272 9137413 49.47 µM -0.302623932802757 0.374321180455193 no 2125 0.38108823673543 2902 17614870
SGTC_1323 1348-1351 11.2 µM -0.303297897178436 0.374050652482223 no 2126 0.380831424286947 2960 6989654
SGTC_769 0302-0231 76 µM -0.303532622283839 0.373956448841569 no 2127 0.380741995188073 3041 571869 YER009W NTF2
SGTC_638 3970-0837 4.09 µM -0.304722895747645 0.373478865199873 no 2128 0.380288605076858 2955 4118451 YLR208W SEC13
SGTC_2921 7974240 10.71 µM -0.304963964149691 0.373382162887626 no 2129 0.380196799097939 3069 2979074 YDR527W RBA50
SGTC_1471 k673-0312 37 µM -0.305098221748229 0.373328310176763 no 2130 0.380145672758466 2978 24099884
SGTC_714 4296-0578 26.1 µM -0.305104476283896 0.373325801450196 no 2131 0.380143291033603 2941 1589775
SGTC_1379 2144-0755 36.5 µM -0.30638344265704 0.372812914383325 no 2132 0.379656356721936 3125 5392327
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.30671647809768 0.372679398508658 no 2133 0.37952959312173 3002 1377
SGTC_490 phenamil 164 µM -0.308555275126817 0.371942489702007 no 2134 0.378829923488413 3018 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3288 9119690 36.221 µM -0.310336499432923 0.371229100491606 no 2135 0.378152538900737 2977 17595618 YKL019W RAM2
SGTC_812 4251-0442 148 µM -0.310658126775171 0.371100334200836 no 2136 0.378030266576223 3086 5723007
SGTC_111 0083-0039 52.457 µM -0.31126086442662 0.370859061833952 no 2137 0.377801158101762 2911 759313
SGTC_624 k048-0052 28 µM -0.31146228779537 0.370778444546621 no 2138 0.377724604019034 3004 6835531
SGTC_476 mead acid 10 µM -0.311768714528382 0.370655811802251 no 2139 0.377608150986701 2935 5312531 An omega 9 fatty acid.
SGTC_2491 paeonol 100 µM -0.312999834689395 0.370163246998114 no 2140 0.377140393871664 2901 11092 Increases levels of cortical cytochrome oxidase.
SGTC_102 gallobenzophenone 83.616 µM -0.313627696502336 0.369912124643454 no 2141 0.376901910689384 3132 70837
SGTC_1976 st070609 63.5 µM -0.315013991665066 0.369357852517961 no 2142 0.376375515250458 2894 682556
SGTC_2499 avocadenofuran 51.48 µM -0.315613265187112 0.369118333389649 no 2143 0.376148033905191 2940 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_257 daunorubicin 18.5 µM -0.315965901525315 0.368977414562092 no 2144 0.376014194949475 3062 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_396 dithiazanine 1.25 µM -0.317248593218828 0.368464980167375 no 2145 0.375527490350999 2972 10578 An antihelmenthic.
SGTC_1479 0549-0158 134 µM -0.3173157382627 0.368438162204751 no 2146 0.375502018280083 3005 5440202
SGTC_1637 st007924 17.4 µM -0.319204479906204 0.367684055272042 no 2147 0.374785730027093 2941 683336
SGTC_765 1319-0117 244 µM -0.319298829868786 0.367646398055571 no 2148 0.37474995995631 2957 3487746 YGL099W LSG1
SGTC_2353 9059630 146.67 µM -0.319425381038777 0.367595890602656 no 2149 0.374701983417279 3073 4779114
SGTC_680 0417-1641 114 µM -0.320580985200131 0.367134786967918 no 2150 0.37426397463201 2937 2835990
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.321149706016783 0.366907929010717 no 2151 0.374048471848223 2931 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_177 1327-0068 8.361 µM -0.321469994536732 0.366780189059867 no 2152 0.373927123700585 3058 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_159 3970-0959 50 µM -0.32421863136395 0.365684564251405 no 2153 0.372886258751618 3069 6615653
SGTC_1801 st050089 28.441 µM -0.324769015585021 0.365465308734634 no 2154 0.372677948210414 2969 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_175 3793-3120 23.7 µM -0.325656293110034 0.365111938245826 no 2155 0.372342208020661 2983 5322297
SGTC_8 0354-0001 70 µM -0.327058583077846 0.364553690563644 no 2156 0.371811788269986 3007 4993152
SGTC_82 0054-0107 293.755 µM -0.327257727665801 0.364474434920728 no 2157 0.371736481023161 3042 3104697
SGTC_1697 st025554 27.742 µM -0.329942212915372 0.363406629070224 no 2158 0.370721813267168 2961 1269519
SGTC_985 1493-0307 8.71 µM -0.330230786067446 0.363291906507711 no 2159 0.370612793247833 3134 3278274
SGTC_1732 st034308 51.822 µM -0.330326809208786 0.363253735124521 no 2160 0.370576518978998 2893 830119
SGTC_3221 9128209 49.47 µM -0.331463242527271 0.362802080264722 no 2161 0.370147300686994 3021 16460723
SGTC_2629 bisabolol 100 µM -0.332227445542054 0.362498468854096 no 2162 0.369858760532779 3164 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1339 1486-1321 22.7 µM -0.332357425590509 0.362446837474878 no 2163 0.369809691246744 3013 3469382
SGTC_1803 st050068 52.4 µM -0.333938177443637 0.361819123131303 no 2164 0.369213105181622 3076 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3224 9130643 49.47 µM -0.334405930438403 0.361633450242759 no 2165 0.369036632454213 3182 17644395
SGTC_2958 9077254 16.72 µM -0.336552960224587 0.360781612909739 no 2166 0.36822696085013 3193 16457351
SGTC_2307 7538926 6.34 µM -0.337756157678733 0.360304543985636 no 2167 0.367773475641809 3034 96582
SGTC_50 0929-0078 56.389 µM -0.338106952838537 0.360165494277886 no 2168 0.367641295585368 2987 1377751
SGTC_3038 9091290 49.47 µM -0.338193256305972 0.360131287769466 no 2169 0.367608778732782 3156 25236843
SGTC_2679 rapamycin 1 nM -0.338671222053232 0.359941865611909 no 2170 0.367428711132127 3077 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_395 anisomycin 6.25 µM -0.340685314561801 0.359144040775235 no 2171 0.366670247645071 3055 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1526 st051518 75 µM -0.340766300560396 0.359111973316084 no 2172 0.366639760939324 3045 673993
SGTC_2196 6573537 42.6665 µM -0.341031387565923 0.359007015612693 no 2173 0.366539976370724 3121 2903087
SGTC_408 cantharidin 100 µM -0.343002396808751 0.358226954723995 no 2174 0.365798328514556 3038 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_187 1488-2104 32.728 µM -0.344876911494649 0.357485631765711 no 2175 0.365093454442563 3072 2852859
SGTC_2427 5545055 42.75 µM -0.346448971738904 0.356864336053618 no 2176 0.364502663489747 3016 5372858
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.346991875915643 0.356649862347162 no 2177 0.364298711063065 3151 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2172 5754775 163.918 µM -0.347813612387316 0.356325322465147 no 2178 0.363990083004375 3004 2263357
SGTC_1514 1189-1591 158 µM -0.35060995557078 0.35522170411951 no 2179 0.362940493328003 3193 767698 YMR146C TIF34
SGTC_2304 7443016 91.4 µM -0.353805434744127 0.353962046375444 no 2180 0.361742350138383 2965 939854
SGTC_2889 9059656 51.95 µM -0.353914641298434 0.353919025297343 no 2181 0.361701427063348 3116 3949838
SGTC_1279 0874-0590 65.2 µM -0.354319021655906 0.353759739023636 no 2182 0.361549907005745 3076 3523074
SGTC_2927 9011802 47.9 µM -0.354452918896474 0.35370700225868 no 2183 0.361499740910624 3121 43912568
SGTC_866 0495-0101 262 µM -0.354645588335218 0.35363112240314 no 2184 0.361427559333658 3012 635694
SGTC_158 k038-0087 26.446 µM -0.355423023256654 0.35332500088018 no 2185 0.361136351649507 2983 X158
SGTC_2146 5545642 200 µM -0.355588270905919 0.353259945450758 no 2186 0.361074464374413 3096 825326
SGTC_2383 9036125 200 µM -0.356012614462773 0.353092907638407 no 2187 0.360915559160513 3025 79580
SGTC_974 1326-0144 138 µM -0.356846044498475 0.352764920191228 no 2188 0.360603531990818 3063 5411856
SGTC_962 1254-0300 21.5 µM -0.357820888123655 0.352381419773207 no 2189 0.360238678855768 2982 7340576
SGTC_2334 9017922 200 µM -0.357849937333577 0.352369994205415 no 2190 0.360227808606189 3157 3163164
SGTC_1947 st076332 61.6 µM -0.358260483398565 0.352208533430864 no 2191 0.360074193857961 3154 24208416
SGTC_1597 7-benzyloxygramine 47.5 µM -0.358358257967503 0.352170084284397 no 2192 0.360037612704471 3037 260807
SGTC_1937 st074714 47.2 µM -0.360170386351822 0.351457751727718 no 2193 0.359359859472254 3004 17250970
SGTC_1964 st076914 61 µM -0.361040870750355 0.351115756785142 no 2194 0.359034447148635 3041 24208661
SGTC_1050 3232-1156 69.3 µM -0.361190417706201 0.351057015069549 no 2195 0.358978552444293 3089 700529
SGTC_320 4092-0846 5.34 µM -0.361428890007495 0.350963351036677 no 2196 0.358889427228658 3128 1359356
SGTC_554 4483-2211 187 µM -0.361549698928875 0.350915904743088 no 2197 0.358844279753978 3120 747107
SGTC_2558 carylophyllene oxide 100 µM -0.362416386603308 0.350575591471554 no 2198 0.35852044795153 3019 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1391 3442-0225 151 µM -0.362448096755851 0.350563142446226 no 2199 0.358508601601557 3021 5227075
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.362876105404325 0.350395127094705 no 2200 0.358348718495277 3009 803109
SGTC_3235 9132602 49.47 µM -0.363255946669124 0.350246044424007 no 2201 0.358206849163787 3160 4912240
SGTC_2098 5376439 882.5 nM -0.365420258493077 0.34939702154207 no 2202 0.357398860606447 3143 2844116
SGTC_3143 9086658 49.47 µM -0.366110651693763 0.349126350177645 no 2203 0.357141254794245 3094 25236626
SGTC_3246 9135460 32.98 µM -0.368480493404504 0.348197828921044 no 2204 0.356257493772469 3128 41446951
SGTC_2484 5809818 12.04 µM -0.369115493376676 0.347949185520887 no 2205 0.356020820539153 3078 2870548
SGTC_1831 st055328 12 µM -0.36929749303434 0.347877932976645 no 2206 0.355952996984092 3187 1103068
SGTC_52 0329-0193 875 nM -0.370229992544352 0.347512945383001 no 2207 0.355605565509952 3257 3739292
SGTC_1340 1486-1359 257 µM -0.37050196348517 0.34740652043674 no 2208 0.355504256919408 3066 4309068
SGTC_428 3448-4153 16.5 µM -0.372095572151391 0.346783167415321 no 2209 0.354910846472405 2976 3834874
SGTC_2716 st080858 38.6235 µM -0.373078363212435 0.346398947208379 no 2210 0.354545060841791 3198 5296050
SGTC_364 0083-0097 67.7 µM -0.373563609186415 0.346209299500302 no 2211 0.35436450626362 3183 5207356
SGTC_2259 7964009 200 µM -0.375308150172078 0.345527802847041 no 2212 0.353715652738308 3212 313134
SGTC_2267 7931562 200 µM -0.378430358656763 0.344309377197433 no 2213 0.35255545958826 3013 934880
SGTC_798 1287-0182 476 µM -0.37883494743338 0.344151606397844 no 2214 0.352405216990977 3240 1649755
SGTC_1737 st035557 69.7 µM -0.379121419440209 0.344039912042734 no 2215 0.352298850557097 3092 5716916
SGTC_1811 st050069 61.5 µM -0.381078799267244 0.34327710157547 no 2216 0.351572389180019 3166 3877702
SGTC_3124 9127567 49.47 µM -0.382569135616242 0.342696730267018 no 2217 0.351019629281286 3250 17592030
SGTC_350 k064-0020 19.8 µM -0.382671495654966 0.342656882513731 no 2218 0.350981675896025 3246 2790705
SGTC_3191 9110352 49.47 µM -0.38273155304189 0.342633503580408 no 2219 0.3509594083164 3129 17122424
SGTC_1138 3761-0006 1.03 µM -0.384203755532223 0.342060598337753 no 2220 0.350413717513644 3166 12061087
SGTC_95 0471-0001 561.058 µM -0.38483772995129 0.341814000071449 no 2221 0.350178821726489 3091 4015405
SGTC_2447 5741742 33.78 µM -0.387136364001412 0.340920462442384 no 2222 0.349327628966017 3178 1776504
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.387336349272681 0.340842765161963 no 2223 0.34925360942045 3159 1241132 A phosphatase inhibitor.
SGTC_777 1315-0167 517 µM -0.387415540286782 0.340812000129738 no 2224 0.349224300432079 3146 4221767
SGTC_3342 9147791 14.508 µM -0.387791378575567 0.340666004605286 no 2225 0.349085213074325 3082 1838168
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.388435201379026 0.340415965152231 no 2226 0.34884699917004 3269 23847180
SGTC_1885 st057546 99.9 µM -0.388697801724252 0.340314000006311 no 2227 0.348749854357519 3263 702008
SGTC_2649 anisomycin 9.56 µM -0.389516455767158 0.339996199601514 no 2228 0.348447070004822 3151 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1167 k781-0610 148 µM -0.389702103367512 0.339924147253261 no 2229 0.348378420492723 3122 4525169
SGTC_707 0865-0008 204 µM -0.391955736006416 0.339049948889679 no 2230 0.347545459873894 3078 723043
SGTC_2318 6029776 164 µM -0.391998660652019 0.339033306536936 no 2231 0.347529601708171 3274 818325
SGTC_2541 muurolladie-3-one 83.07 µM -0.392603920879941 0.338798674006948 no 2232 0.347306021595259 3261 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_795 0685-0265 78 µM -0.393100016098148 0.338606406535449 no 2233 0.347122806104714 3095 302754
SGTC_2525 harmine 47.85 µM -0.393630520718927 0.338400849831531 no 2234 0.346926922229952 3103 5280953 A monoamine oxidase inhibitor
SGTC_1722 st034304 3.6505 µM -0.393825832675727 0.338325183664743 no 2235 0.3468548154132 3102 4036148 YLR033W RSC58
SGTC_632 0781-2353 4.65 µM -0.394328108155016 0.338130626179184 no 2236 0.346669406846005 3175 6811515 YHR007C ERG11
SGTC_1560 lithocholic acid 53.1 µM -0.394352010421956 0.338121368661701 no 2237 0.34666058454491 3171 9903 A bile acid which acts as a detergent.
SGTC_2606 farnesol 9.78 µM -0.396398863799916 0.33732897142852 no 2238 0.34590540207148 3252 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_90 0870-0863 4.608 µM -0.39785848455812 0.336764349366604 no 2239 0.345367251859077 3066 1738164
SGTC_609 0986-0026 86.3 µM -0.398294102361774 0.336595911428112 no 2240 0.345206703635763 3107 2848610
SGTC_405 ebelactone b 50 µM -0.398867693765158 0.336374173997782 no 2241 0.344995347323882 3131 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1915 st067105 30.6 µM -0.399252739275241 0.336225356047949 no 2242 0.344853493308413 3158 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2610 ononetin 44.17 µM -0.400253140169781 0.33583882665447 no 2243 0.344485039144416 3165 259632
SGTC_1185 1319-0113 81.3 µM -0.402304942611284 0.335046605967681 no 2244 0.343729808787898 3211 4672763
SGTC_2849 9019321 12.99 µM -0.403195814844041 0.334702859722688 no 2245 0.343402089135398 3210 16489627
SGTC_2179 6298986 200 µM -0.403824253790979 0.334460457581654 no 2246 0.343170979973432 3223 738374
SGTC_3097 9117246 49.47 µM -0.40448828498133 0.334204401731074 no 2247 0.342926845442855 3126 16423892
SGTC_1145 3546-0597 10.2 µM -0.4063891434389 0.333471841982236 no 2248 0.342228347699222 3154 875334
SGTC_3238 9133470 49.47 µM -0.406459573076961 0.333444711727295 no 2249 0.342202477666608 3235 3534688
SGTC_2925 9010536 32.5 µM -0.406828059244642 0.333302781093209 no 2250 0.342067138355654 3144 2994177
SGTC_2924 9010168 62.78 µM -0.407350490273651 0.333101596082557 no 2251 0.341875292235775 3206 2993929
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.408356716221837 0.332714239950555 no 2252 0.34150590294488 3129 364106
SGTC_1298 1079-1278 263 µM -0.408500416687686 0.332658935663846 no 2253 0.341453162345059 3171 2840950
SGTC_1806 st050005 60.3 µM -0.408807925490996 0.332540600648802 no 2254 0.341340311604765 3135 5194765
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.409405393678531 0.332310731669434 no 2255 0.341121091040725 3138 6708784 An antioxidant flavonoid
SGTC_3186 9110464 49.47 µM -0.409484655884921 0.33228024118809 no 2256 0.341092012505608 3243 17018021
SGTC_834 0312-0008 75.7 µM -0.410186287219319 0.332010386993325 no 2257 0.34083464964598 3139 6385573 YIL048W NEO1
SGTC_857 0438-0306 1.35 µM -0.410239115061484 0.33199007241901 no 2258 0.340815275052331 3222 4686136
SGTC_2261 9010538 184.68 µM -0.41027924507892 0.331974641033742 no 2259 0.340800557662327 3218 6457250
SGTC_774 k060-0086 136 µM -0.410327951233299 0.331955912208866 no 2260 0.34078269536243 3306 5911235
SGTC_2687 chenodiol 100 µM -0.411340752051585 0.331566558284048 no 2261 0.34041134579162 3235 5702181 A cholesterol synthesis inhibitor.
SGTC_304 1310-0298 97 µM -0.411394567478435 0.331545874951596 no 2262 0.340391618363428 3191 1550234
SGTC_2717 st081029 62.2815 µM -0.411428006808319 0.331533023193407 no 2263 0.340379360537407 3231 5292846
SGTC_2588 indole-3-carbinol 100 µM -0.411701534887116 0.331427905426515 no 2264 0.340279099920469 3250 3712 Induces cell cycle arrest.
SGTC_1146 3579-1023 7 µM -0.412121066731886 0.331266703720655 no 2265 0.340125344150364 3238 X1146
SGTC_3276 9139060 49.47 µM -0.412128947493535 0.331263675901013 no 2266 0.340122456155303 3126 4870619
SGTC_3109 9122853 49.47 µM -0.415380356874457 0.330015414741847 no 2267 0.338931742064298 3181 1234709
SGTC_1661 st013063 9.66 µM -0.416082634788337 0.329746048254523 no 2268 0.338674768215033 3149 721395
SGTC_1319 1306-0155 43.7 µM -0.41793522725801 0.329035889763911 no 2269 0.337997237832741 3152 3122360
SGTC_31 0508-1974 57.237 µM -0.418540632983266 0.328803951756199 no 2270 0.33777594235218 3235 6810525
SGTC_2598 perillyl alcohol 100 µM -0.419051247084983 0.328608380766084 no 2271 0.337589339875591 3278 10819 An apoptosis inducer.
SGTC_3117 9124945 49.47 µM -0.419339113005936 0.328498145540797 no 2272 0.337484157686164 3077 17592065
SGTC_2374 9071832 200 µM -0.419943966629236 0.328266571848969 no 2273 0.337263193987836 3249 17381698
SGTC_148 3253-0744 288.01 µM -0.420174396721755 0.328178366949505 no 2274 0.337179028568758 3213 6893655
SGTC_1252 0493-0875 34.8 µM -0.421848813148421 0.327537715484659 no 2275 0.336567686919797 3121 3960963
SGTC_471 1-acyl-paf 4 µM -0.422088745456285 0.327445956081063 no 2276 0.336480121210716 3148 16759367
SGTC_1396 3511-0007 98.6 µM -0.422279060305467 0.327373179727381 no 2277 0.336410670198539 3215 X1396
SGTC_518 1021-0119 62.6 µM -0.423379087140263 0.326952658346225 no 2278 0.336009350217683 3153 1097762
SGTC_486 niguldipine 82 µM -0.426521121624147 0.325752723661064 no 2279 0.334864080295602 3139 1236 A calcium channel blocker.
SGTC_664 1222-0054 14.9 µM -0.426961388052414 0.325584730810513 no 2280 0.334703725717992 3168 6813991
SGTC_3174 9107204 49.47 µM -0.427356086171022 0.325434155609583 no 2281 0.334559993728094 3266 3938802
SGTC_3116 9124943 49.47 µM -0.427878568894214 0.325234875090956 no 2282 0.33436976539843 3169 41905195 YPL160W CDC60
SGTC_1493 4348-0038 111 µM -0.428079459709107 0.32515826647507 no 2283 0.334296635301988 3251 800424
SGTC_1265 0819-1001 68.8 µM -0.428717616365106 0.324914957953161 no 2284 0.334064369458032 3239 3106768
SGTC_2100 5377183 190 µM -0.429644096354752 0.324561853956379 no 2285 0.333727277494621 3215 2844202
SGTC_1829 berberine 14.4 µM -0.43007090021163 0.324399241672286 no 2286 0.333572033617327 3300 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_719 2810-4230 27.3 µM -0.430204960521022 0.324348171598003 no 2287 0.333523276951871 3211 721079
SGTC_2982 9019404 25.97 µM -0.431647209001079 0.323798958329992 no 2288 0.332998920675394 3138 22333232
SGTC_2965 9082772 38.63 µM -0.432458821656352 0.323490061910757 no 2289 0.332703987224332 3342 16459634
SGTC_1624 st003710 6.25 µM -0.433676224425708 0.323026951494797 no 2290 0.332261787047756 3269 24207033
SGTC_46 0329-0187a 2.197 µM -0.435392242523143 0.322374629326365 no 2291 0.331638870103862 3238 46494817
SGTC_576 1073-0113 22.7 µM -0.435711837701096 0.322253199653751 no 2292 0.331522907959104 3348 5439563
SGTC_86 0417-1630 471.922 µM -0.43717125757807 0.32169893664446 no 2293 0.330993576361577 3263 3634867
SGTC_1055 3448-0672 86 µM -0.439263253387946 0.320905123854757 no 2294 0.330235398533195 3305 748378
SGTC_1955 wogonin 32.4 µM -0.439460902620368 0.320830167620578 no 2295 0.330163802773226 3371 5281703 A flavanone.
SGTC_2565 isoliquiritigenin 100 µM -0.439623537685027 0.32076849559002 no 2296 0.330104895085257 3261 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2263 7948595 193.29 µM -0.439978203291642 0.320634021772778 no 2297 0.329976447046862 3156 2971371
SGTC_1004 4084-0029 199 µM -0.440335016079595 0.320498757588463 no 2298 0.32984724159562 3292 716894 YLR208W SEC13
SGTC_1626 st003712 1.76 µM -0.441324374493608 0.320123826369297 no 2299 0.329489091310124 3304 24207035
SGTC_1502 4534-4282 27.7 µM -0.441813277936272 0.319938617324817 no 2300 0.329312164710381 3211 3278949
SGTC_2165 5727197 32.143 µM -0.442574640608472 0.319650283165199 no 2301 0.329036715428708 3481 1361712
SGTC_3298 9116858 71.43 µM -0.443271439722891 0.31938649523693 no 2302 0.328784705573329 3299 2506942
SGTC_1316 1272-0050 65.9 µM -0.444019864365381 0.319103265171761 no 2303 0.328514111114949 3224 7340392
SGTC_1439 4092-1168 46 µM -0.444535290104093 0.318908271416102 no 2304 0.328327810158529 3251 2886240
SGTC_1285 0929-0069 65.5 µM -0.445630372213078 0.318494150826085 no 2305 0.327932133765345 3220 1206237
SGTC_2790 5423970 71.43 µM -0.446157946150267 0.318294722242215 no 2306 0.327741578991931 3320 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_525 k781-2675 26.7 µM -0.446351913723932 0.318221413661969 no 2307 0.327671530991091 3298 3651118 YDL195W SEC31
SGTC_1747 st037496 66.6 µM -0.446884971387479 0.318019985216094 no 2308 0.327479057767508 3170 723305
SGTC_3088 9117578 49.47 µM -0.449411116725764 0.317066154142215 no 2309 0.326567556706818 3299 678341
SGTC_951 1171-0579 82.7 µM -0.449699301070232 0.316957417501027 no 2310 0.32646363769311 3232 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3140 9094243 49.47 µM -0.452191073465534 0.316017891265719 no 2311 0.325565669164743 3311 19291112
SGTC_1218 1348-1416 30.7 µM -0.452642603567196 0.315847768078352 no 2312 0.325403057813888 3206 6787668
SGTC_2620 irigenin 100 µM -0.453010659397614 0.315709124377109 no 2313 0.325270532970785 3358 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_496 calpeptin 138 µM -0.45380738038384 0.315409094758239 no 2314 0.324983735550573 3246 73364 A calpain inhibitor.
SGTC_757 1066-0008 322 µM -0.454101646540564 0.3152983106075 no 2315 0.324877834119435 3297 6842497
SGTC_458 nppb 133 µM -0.45430981501151 0.315219950198325 no 2316 0.324802926339899 3367 4549 A chloride channel blocker.
SGTC_2987 9018338 71.43 µM -0.454920562181083 0.31499009593896 no 2317 0.324583194686318 3352 5055682
SGTC_2622 2-methoxyxanthone 59.94 µM -0.455780499094548 0.31466658074236 no 2318 0.32427391425204 3205 71034 A hepatoprotective.
SGTC_2404 5161160 200 µM -0.455979313729269 0.314591805306736 no 2319 0.324202426857947 3203 2831543
SGTC_1073 triclabendazole 3.09 µM -0.456351893187038 0.314451696306017 no 2320 0.324068476635342 3298 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.456752113395436 0.314301222732251 no 2321 0.323924614346822 3169 107982 A Capsaicinoid.
SGTC_2233 sulbentine 40.3845 µM -0.460942688640896 0.312727519754728 no 2322 0.32241986184354 3254 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1394 3474-0001 65.7 µM -0.461042173721952 0.312690201035256 no 2323 0.322384173927349 3243 5017666 YIL048W NEO1
SGTC_2200 6600604 21.907 µM -0.461430370359039 0.312544599563704 no 2324 0.322244933237072 3212 2904777
SGTC_2139 5578692 56.4705 µM -0.461731758476622 0.312431577660228 no 2325 0.322136846742135 3276 650991 YMR113W FOL3
SGTC_2723 salbutamol 83.58 µM -0.463277374929682 0.311852241934902 no 2326 0.321582780494628 3286 9884233 β2-adrenoceptor agonist
SGTC_977 1348-1378 135 µM -0.463278169949702 0.311851944061096 no 2327 0.321582495601074 3185 X977
SGTC_204 PMA1.184 62.41 µM -0.464115586655794 0.311538253663377 no 2328 0.321282467587246 3251 2252213 YGL008C PMA1
SGTC_448 monastrol 171 µM -0.464121246294546 0.311536134067546 no 2329 0.321280440259428 3266 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2056 5235370 200 µM -0.464352802514309 0.311449419118447 no 2330 0.321197499538112 3192 5511916
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.465885524585118 0.310875697521137 no 2331 0.320648721511416 3261 5379071
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.466821938913032 0.310525409132977 no 2332 0.320313639077412 3406 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_701 4424-0219 185 µM -0.467308748913419 0.310343373925995 no 2333 0.320139498942985 3381 2911779
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.467652419641723 0.310214891443834 no 2334 0.320016585987185 3187 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1924 st058459 75.1 µM -0.469339806266101 0.309584392445768 no 2335 0.319413383279707 3305 688683
SGTC_1273 0849-0096 14.1 µM -0.471841200738897 0.308650766662665 no 2336 0.318520070124348 3268 5286025
SGTC_2802 7925815 54.55 µM -0.472554329074711 0.308384823200579 no 2337 0.318265586246897 3202 1262923
SGTC_3350 9150499 3.57 µM -0.474401205628077 0.307696544087033 no 2338 0.317606916741056 3230 4910996 YPR165W RHO1
SGTC_1780 st038448 24.544 µM -0.474463127178827 0.307673479364925 no 2339 0.317584843042266 3375 728868 YDL195W SEC31
SGTC_2718 lomofungin 53.02 µM -0.474618675662742 0.307615543559463 no 2340 0.317529396219718 3362 5351222 A RNA synthesis inhibitor.
SGTC_2943 9068529 45.32 µM -0.475705342848876 0.307210935885186 no 2341 0.317142157006178 3319 3270634
SGTC_2181 6316240 54.2555 µM -0.475797936487451 0.307176470578053 no 2342 0.317109170053939 3307 12779990
SGTC_3349 9149703 23.001 µM -0.475834112979134 0.307163005386803 no 2343 0.31709628239053 3286 4910494
SGTC_2714 st079313 56.9 µM -0.476779142173223 0.306811349812961 no 2344 0.316759699901768 3247 2939799
SGTC_2062 5245942 200 µM -0.478381470312236 0.306215512405658 no 2345 0.31618935980308 3344 1376160
SGTC_2962 9082311 13.18 µM -0.479607998256313 0.3057597650171 no 2346 0.315753078996516 3204 16459453
SGTC_2029 5175081 200 µM -0.4810043618478 0.305241276913116 no 2347 0.315256699328926 3264 1380876
SGTC_3189 9110682 49.47 µM -0.481549403758087 0.305039001623329 no 2348 0.315063038092314 3329 17122418
SGTC_751 0833-0568 350 µM -0.481674702219553 0.304992509427129 no 2349 0.315018524928364 3309 6954252
SGTC_599 1935-0052 86.5 µM -0.482031799602929 0.304860025137147 no 2350 0.314891678299218 3220 9557311
SGTC_1274 0865-0114 173 µM -0.482125366942643 0.304825315578687 no 2351 0.314858445311978 3285 870624
SGTC_64 000l-0018 272.079 µM -0.484304806696292 0.304017332305857 no 2352 0.314084782578284 3276 6811119
SGTC_1752 st044819 83.042 µM -0.484657125513175 0.303886806911698 no 2353 0.3139597921632 3237 441209 YML126C ERG13
SGTC_2735 sertaconazole 140 nM -0.486566900043905 0.303179718133167 no 2354 0.313282642508262 3333 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1465 k213-0056 144 µM -0.487218713520757 0.302938554499555 no 2355 0.31305167256341 3216 24048857 YMR208W ERG12
SGTC_1369 1866-0067 208 µM -0.487390368898839 0.302875058232141 no 2356 0.312990858719496 3383 3531355
SGTC_1808 st050063 61.5 µM -0.488363758951193 0.302515108652492 no 2357 0.312646103622967 3374 4011993
SGTC_2835 9006588 71.43 µM -0.492095474979314 0.301136939119335 no 2358 0.311325925490481 3401 2345538
SGTC_1104 tacrolimus 29.8 µM -0.49231148012677 0.301057252391835 no 2359 0.31124958285483 3363 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2772 vinpocetine 57.06 µM -0.494171882467858 0.300371322861659 no 2360 0.310592397740801 3436 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3019 9081971 49.47 µM -0.49449172013768 0.30025347002522 no 2361 0.310479476218564 3432 16451803
SGTC_625 k213-0058 121 µM -0.495011558553764 0.300061966116887 no 2362 0.310295980765002 3334 3655420
SGTC_3009 9080819 71.4286 µM -0.49552805960246 0.299871746406706 no 2363 0.310113710112251 3322 17027216
SGTC_999 SEC7.066 22.7 µM -0.495572727605504 0.299855298405547 no 2364 0.310097949186864 3252 740511 YDR170C SEC7
SGTC_1432 4049-0298 68.4 µM -0.496766590693462 0.299415836236547 no 2365 0.309676828745245 3358 741646
SGTC_1259 0671-0132 43 µM -0.497328732600419 0.29920901243138 no 2366 0.309478626571472 3234 X1259
SGTC_292 k038-0015 474 µM -0.498352001006953 0.298832697019078 no 2367 0.309117980876476 3373 46368540
SGTC_1943 st076331 65.2 µM -0.498458480125949 0.298793550800073 no 2368 0.309080463414597 3380 24208415
SGTC_586 0957-0265 8.15 µM -0.498604261595297 0.29873995915791 no 2369 0.309029101167137 3310 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_728 3030-5151 22.5 µM -0.499126214055075 0.298548116770444 no 2370 0.308845235631472 3309 3125388
SGTC_1616 st002734 56.1 µM -0.500258027139956 0.298132314185509 no 2371 0.308446702177352 3245 4026101
SGTC_1237 0330-0133 46.1 µM -0.5004348828997 0.2980673652103 no 2372 0.308384448185343 3287 X1237 YHR072W ERG7
SGTC_2975 9084847 53.72 µM -0.501032026369211 0.297848116319651 no 2373 0.308174291817728 3339 27211724
SGTC_2652 actinonin 100 µM -0.501739425085054 0.297588481009051 no 2374 0.307925413998637 3274 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2776 terbinafine 19.92 µM -0.503124066497193 0.297080577739714 no 2375 0.30743852359476 3352 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_909 3448-9333 149 µM -0.503869166272655 0.296807430252087 no 2376 0.307176659626352 3271 3344074
SGTC_852 0418-0143 439 µM -0.504575952165174 0.296548434613667 no 2377 0.306928351843331 3389 5369229
SGTC_2887 9044784 58.44 µM -0.50571858023091 0.296129947499803 no 2378 0.306527111440878 3325 6465546
SGTC_2902 5787006 60.46 µM -0.508290276855225 0.295189057248531 no 2379 0.305624893922702 3246 591003
SGTC_3158 9100007 49.47 µM -0.508361614755428 0.295162976935378 no 2380 0.30559988352669 3275 19297233
SGTC_347 4534-1311 26.2 µM -0.508570971599903 0.295086444614963 no 2381 0.3055264902256 3346 2862016
SGTC_674 0498-0004 451 µM -0.510343971592426 0.294438674910118 no 2382 0.304905251012535 3334 4231473
SGTC_2161 5662504 8.5105 µM -0.510425164993623 0.294409026435002 no 2383 0.304876815203266 3302 2859334
SGTC_1812 st052057 4.327 µM -0.511328703078595 0.294079184711698 no 2384 0.304560454799277 3311 3645418
SGTC_474 dl-dihydrosphingosine 5 µM -0.511611524342108 0.29397597430921 no 2385 0.304461459165475 3427 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_279 1273-0055 2.93 µM -0.512706221204574 0.293576642847345 no 2386 0.304078418622284 3366 2847562
SGTC_420 mitomycin C 81.9 mM -0.513149956744788 0.293414845348023 no 2387 0.303923214277307 3289 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_411 enrofloxacin 100 µM -0.513423713363743 0.29331504718638 no 2388 0.303827480686629 3454 71188 A bacterial gyrase inhibitor.
SGTC_2642 cholecalciferol 100 µM -0.513585119078326 0.293256213996139 no 2389 0.30377104288166 3375 9821465 A vitamin D precursor, similar to steriods.
SGTC_2191 5911152 200 µM -0.514045298004651 0.293088506513601 no 2390 0.303610160458034 3333 2875902
SGTC_2932 9016711 44.54 µM -0.514705658053954 0.292847922827375 no 2391 0.30337935951911 3400 7117328
SGTC_2156 5649887 115 µM -0.516894718250212 0.292051056454728 no 2392 0.302614827429 3405 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1621 st003705 32.4 µM -0.51783453134808 0.291709253654652 no 2393 0.302286861612231 3426 24207032
SGTC_1733 st037357 54.9 µM -0.519615153334397 0.291062166884619 no 2394 0.301665917145756 3257 1272339 YGL099W LSG1
SGTC_2315 7733312 200 µM -0.521257766608776 0.290465828379049 no 2395 0.301093608725119 3286 726316
SGTC_950 1165-0508 94.1 µM -0.522897649738411 0.289871052121852 no 2396 0.300522740117196 3367 6148369
SGTC_1855 st056195 39.6 µM -0.52327673502061 0.289733641383924 no 2397 0.300390844272499 3433 4028379
SGTC_2359 9039622 200 µM -0.523735080585352 0.289567541231624 no 2398 0.300231406189822 3348 6463596
SGTC_463 ikarugamyin 104 µM -0.52458455851921 0.28925981663645 no 2399 0.299936011719066 3390 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1124 fisetin 1.16336 µM -0.524635030098731 0.289241538073225 no 2400 0.299918465049832 3343 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3123 9126162 49.47 µM -0.525163104746771 0.289050325467985 no 2401 0.299734905415862 3344 25239884
SGTC_650 1328-0195 38 µM -0.52523877748011 0.289022929704641 no 2402 0.299708605615345 3394 2780821
SGTC_210 3551-0445 56.827 µM -0.525788224880743 0.288824050166012 no 2403 0.299517678399842 3446 2865180 YOR207C RET1
SGTC_1944 st076371 56.9 µM -0.525868605613591 0.288794960730372 no 2404 0.299489751560452 3283 24208455
SGTC_2127 5253358 187.912 µM -0.525994335785139 0.288749462297438 no 2405 0.29944607124185 3285 20612
SGTC_1769 st044406 64.4 µM -0.526928013500876 0.288411694596576 no 2406 0.299121789705796 3306 670903
SGTC_2140 5586273 200 µM -0.527102427567382 0.288348619131328 no 2407 0.299061230523338 3392 854421
SGTC_1654 st012436 41.8 µM -0.527265394338309 0.28828968936819 no 2408 0.299004651044844 3386 4323132
SGTC_70 0141-0289 43.283 µM -0.527745975668604 0.288115941350815 no 2409 0.298837829138903 3336 352408
SGTC_1644 st010134 20.9 µM -0.527851926809596 0.28807764272303 no 2410 0.298801056514958 3410 3818134
SGTC_1694 st024011 44.9 µM -0.527869828481334 0.288071171963801 no 2411 0.298794843557552 3434 2787533
SGTC_171 k064-0041 9.68 µM -0.528370499318289 0.287890226689234 no 2412 0.298621104434978 3312 53325
SGTC_767 0929-0023 86 µM -0.529457335281902 0.28749762283885 no 2413 0.298244116782945 3442 1204563
SGTC_258 haloperidol 50.781 µM -0.52982328396837 0.287365486139963 no 2414 0.298117230007528 3359 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_101 0490-5701 117.494 µM -0.530782193867711 0.287019379435074 no 2415 0.297784860255691 3386 4661669
SGTC_3243 9134147 49.47 µM -0.530965282874617 0.286953318169614 no 2416 0.297721418616598 3424 24282180
SGTC_286 k060-0067 22.9 µM -0.533802677188451 0.285930465601631 no 2417 0.296739030667819 3350 5985051
SGTC_2571 chrysanthemic acid 100 µM -0.535426626076097 0.285345829022354 no 2418 0.296177441242739 3345 2743 An insecticide.
SGTC_3332 9141069 11.198 µM -0.535737928818484 0.285233822231979 no 2419 0.296069843124097 3314 17332883
SGTC_2696 st077691 74.316 µM -0.537013691675647 0.284775021474689 no 2420 0.295629078274839 3435 757133
SGTC_1016 4226-1401 38 µM -0.53914581511357 0.284009036069859 no 2421 0.294893122445063 3418 2901613
SGTC_1760 st045453 10.4495 µM -0.539974671269021 0.283711528017181 no 2422 0.294607250077821 3445 3323419 YIL048W NEO1
SGTC_2788 5282734 71.43 µM -0.540355512688354 0.283574879584817 no 2423 0.294475940809792 3466 743706
SGTC_1311 1190-0148 100 µM -0.540849818833537 0.283397566295841 no 2424 0.294305550645608 3455 1961333
SGTC_307 1501-1223 22.3 µM -0.541077606748627 0.283315874050323 no 2425 0.294227046173314 3413 2830329
SGTC_569 4130-2812 160 µM -0.541127336847112 0.283298040701731 no 2426 0.294209908556222 3376 743552
SGTC_2728 chlorpromazine 9.18 µM -0.541224147412181 0.283263325713893 no 2427 0.294176547741271 3395 2726 A thorazine and dopamine antagonist.
SGTC_2180 6301957 200 µM -0.5446714787917 0.28202849010191 no 2428 0.29298974208873 3422 845462
SGTC_3240 9133527 49.47 µM -0.545044984783886 0.281894855904952 no 2429 0.292861289450268 3388 17617455
SGTC_3302 9125395 16.351 µM -0.54669248735715 0.281305771384827 no 2430 0.292295008192185 3339 17599668
SGTC_398 bronopol 33.3 µM -0.54690332316092 0.281230427399285 no 2431 0.29222257626827 3342 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1489 4065-0444 182 µM -0.547598540348843 0.280982054626998 no 2432 0.291983795949983 3434 2877968
SGTC_1652 st011932 78 µM -0.547808915248632 0.280906917144823 no 2433 0.291911558186077 3419 1551076
SGTC_1420 4'-methoxyflavone 42 µM -0.548042559391829 0.280823480206103 no 2434 0.291831340071199 3438 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3161 9100388 49.47 µM -0.548057995730648 0.280817968138742 no 2435 0.291826040603895 3434 25236368
SGTC_1165 k072-0275 30.3 µM -0.548093367601962 0.280805337611881 no 2436 0.291813897214986 3478 6153523 YGL055W OLE1
SGTC_2026 5148700 152 µM -0.548230835001423 0.28075625359809 no 2437 0.291766706015872 3353 79838
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.549842221703894 0.280181202576525 no 2438 0.291213798233036 3370 5106787 A p450 inhibitor.
SGTC_3222 9128301 49.47 µM -0.550416009759457 0.27997657432614 no 2439 0.291017035122183 3353 4911358
SGTC_2087 5276107 200 µM -0.55087794612548 0.27981188806165 no 2440 0.29085867327935 3418 144405
SGTC_2865 9030313 51.95 µM -0.55200852131106 0.279409021807508 no 2441 0.290471257529383 3319 42562754
SGTC_1366 1683-0113 21.9 µM -0.552485158080331 0.279239262755465 no 2442 0.290308000163884 3405 708623
SGTC_196 k015-0023 18.111 µM -0.552634182638671 0.279186196425497 no 2443 0.290256965173423 3408 5211998
SGTC_2449 5812982 45.77 µM -0.553147711486046 0.279003370894721 no 2444 0.290081134145505 3432 776185
SGTC_869 0564-0080 44.1 µM -0.553870523866775 0.278746135356113 no 2445 0.289833729566712 3399 6843321
SGTC_3203 9113543 49.47 µM -0.554064703327869 0.278677050160697 no 2446 0.28976728259605 3447 17018012
SGTC_639 0833-0042 114 µM -0.554390766607016 0.278561062078272 no 2447 0.289655721906584 3369 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.558692612480646 0.277033003645598 no 2448 0.288185760991623 3404 2374 Ca(2+)-ATPase inhibitor.
SGTC_1235 benzylparaben 21.5 µM -0.559953944682613 0.276585745026899 no 2449 0.287755426023611 3430 7180
SGTC_35 0133-0054 64.071 µM -0.56173927875284 0.275953285077353 no 2450 0.287146834234633 3397 99677
SGTC_1097 itavastatin 7.23 µM -0.562654980034241 0.275629170978932 no 2451 0.286834922939714 3464 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2726 cimetidine 79.27 µM -0.563883199843524 0.275194734488887 no 2452 0.286416812134969 3428 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_433 pimozide 108 µM -0.56403433937266 0.275141297878572 no 2453 0.286365381183319 3313 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_44 0929-0055 61.211 µM -0.564212047130923 0.275078474391163 no 2454 0.286304914993016 3352 1379590
SGTC_882 0843-0131 351 µM -0.564409709531644 0.275008604812229 no 2455 0.286237666230937 3501 5425421
SGTC_5 0352-0601 109.883 µM -0.568045769439855 0.273724894544053 no 2456 0.285001944967426 3407 762456
SGTC_705 1124-0212 310 µM -0.568790440566006 0.273462354686315 no 2457 0.284749181393954 3488 9554485
SGTC_351 caspofungin 25 nM -0.570256054302674 0.272946005035999 no 2458 0.284252021144197 3462 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_114 0364-0001 490.298 µM -0.57199957802237 0.272332375356409 no 2459 0.283661130266106 3467 4003655
SGTC_2313 7726885 200 µM -0.573014041215018 0.271975652742222 no 2460 0.283317593447765 3452 726423
SGTC_1555 citronellol 128 µM -0.573394013493256 0.271842100347258 no 2461 0.283188971388334 3466 8842 A terpine precursor.
SGTC_3241 9133421 49.47 µM -0.576293903539727 0.27082392504128 no 2462 0.282208271445493 3467 17018221
SGTC_2593 nobiletin 86.24 µM -0.577994784413999 0.270227618672473 no 2463 0.281633820247536 3409 72344 An anti-infammatory.
SGTC_1423 4048-0112 5.59 µM -0.579525385502082 0.269691571988783 no 2464 0.281117361410631 3488 X1423
SGTC_248 streptozotocin 5.23457 mM -0.580217848309388 0.269449232968941 no 2465 0.280883859458764 3496 5300 DNA alkylating agent.
SGTC_2883 9059145 45.46 µM -0.580502239200477 0.269349737217703 no 2466 0.280787988582875 3417 16476510
SGTC_212 3807-4682 38.772 µM -0.582092851637606 0.268793592393243 no 2467 0.280252069931099 3509 3125501 YBL034C STU1
SGTC_1300 1094-0077 113 µM -0.582451668446219 0.268668214763786 no 2468 0.280131243755593 3451 5532636
SGTC_83 0170-0301 39.027 µM -0.583037971682919 0.268463412170697 no 2469 0.279933869279305 3439 3089716
SGTC_1103 duloxetine 36.1 µM -0.583634087290999 0.268255262507119 no 2470 0.279733260705198 3539 60835 A selective serotonin reuptake inhibitor.
SGTC_2285 7945142 200 µM -0.585178772471869 0.267716272537302 no 2471 0.27921375833872 3490 2970608
SGTC_1757 st041620 31.8375 µM -0.585206847412654 0.267706481346164 no 2472 0.279204320627022 3481 5289815
SGTC_713 1488-1073 324 µM -0.585349727248438 0.267656654517122 no 2473 0.279156292342549 3478 3312542
SGTC_860 0443-0016 25.1 µM -0.58643772071871 0.267277389315397 no 2474 0.278790701009823 3491 5337942
SGTC_916 4466-0038 42 nM -0.586483456584624 0.267261452125814 no 2475 0.278775337791102 3571 5722064 YGL116W CDC20
SGTC_1082 camptothecin 424.86 nM -0.586617194684712 0.267214852295025 no 2476 0.278730415944641 3375 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3172 9105863 49.47 µM -0.586846875491568 0.267134831666188 no 2477 0.278653275727041 3465 2348785
SGTC_3278 9139605 49.47 µM -0.587242336981033 0.266997081517559 no 2478 0.278520481045399 3557 7958859
SGTC_858 0438-0351 2.77 µM -0.589288351319753 0.266284971667363 no 2479 0.277833928852514 3470 2799119
SGTC_2232 chlorophetanol 41.5365 µM -0.589456113062427 0.266226625308208 no 2480 0.277777672080431 3531 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_759 3486-0358 89.3 µM -0.590049763117928 0.266020209959535 no 2481 0.277578643744375 3549 875103
SGTC_1923 st058458 19.1 µM -0.590220557859438 0.265960838720275 no 2482 0.277521395658599 3562 3534982
SGTC_1904 st060225 78 µM -0.590256828408989 0.265948231307132 no 2483 0.277509239004113 3505 66595
SGTC_1895 st058434 18.3 µM -0.590571893417143 0.265838729447184 no 2484 0.277403650880629 3544 5393175
SGTC_2651 TUB2.036 5 µM -0.592032895640578 0.265331252244347 no 2485 0.276914280277679 3596 15992207 YFL037W TUB2
SGTC_1781 st038725 66.3 µM -0.592878225801683 0.265037852651112 no 2486 0.276631325546032 3452 4270275 YIL048W NEO1
SGTC_3001 9076041 71.4286 µM -0.593279843070596 0.264898515967785 no 2487 0.276496943120164 3511 16004211
SGTC_499 genistein 192 µM -0.594333389641 0.26453317661851 no 2488 0.276144575246423 3510 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2857 9024691 58.44 µM -0.594604641050686 0.264439156025413 no 2489 0.276053888532598 3492 16478292
SGTC_2581 avocatin a 64 µM -0.594809700842123 0.264368089921989 no 2490 0.275985341181851 3447 6710728 A skin care supplement.
SGTC_2028 5153890 36.43 µM -0.595121951475431 0.264259894132811 no 2491 0.27588097815391 3489 2830968 YPR165W RHO1
SGTC_1092 toremifene 6.32 µM -0.597025954396501 0.263600639660426 no 2492 0.275245026184779 3524 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1679 SEC14.276 6.7 µM -0.59743616670116 0.263458715009008 no 2493 0.275108106592704 3492 1005053 YMR079W SEC14
SGTC_928 2764-0428 58.7 µM -0.597478832935031 0.263443955647719 no 2494 0.275093867494633 3513 662578
SGTC_1513 0337-0559 19 µM -0.598507373160006 0.263088284573896 no 2495 0.274750720338601 3410 775073
SGTC_2537 larixol 68.93 µM -0.599373517361886 0.262788960775669 no 2496 0.274461916404882 3528 6708759
SGTC_570 0987-0065 62.6 µM -0.599416803335829 0.26277400649568 no 2497 0.274447487220588 3412 3104428
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.600166031679032 0.262515234813918 no 2498 0.274197794665676 3514 688669
SGTC_1922 5578187 25 µM -0.600333106709582 0.262457547519321 no 2499 0.274142129492755 3573 1350412
SGTC_455 paf C-16 10 µM -0.600354491814639 0.262450164186395 no 2500 0.274135004919841 3496 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1607 st000305 50.6 µM -0.60148072598105 0.262061475560969 no 2501 0.273759922721761 3517 5457690
SGTC_873 0591-4978 488 µM -0.603363489381796 0.261412351321389 no 2502 0.273133452623234 3607 3305145
SGTC_2421 5690543 90.72 µM -0.604177089178418 0.261132100557843 no 2503 0.272862955689433 3532 3397993
SGTC_1341 1486-1360 280 µM -0.604823042450154 0.260909706962458 no 2504 0.272648290735813 3484 3976547
SGTC_2760 etidronate 98.04 µM -0.605229127749831 0.260769946781054 no 2505 0.272513382283705 3480 3305 A chelator and antioxidant.
SGTC_2483 5729050 27.16 µM -0.60676370276177 0.260242148433897 no 2506 0.272003869810536 3579 2865180
SGTC_530 4358-1714 28 µM -0.607403246189097 0.260022347907488 no 2507 0.271791667352328 3520 1564641
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.609765604648212 0.259211274936245 no 2508 0.271008544514224 3452 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1500 4488-1866 171 µM -0.611221552493555 0.258712053731919 no 2509 0.270526458469444 3604 2900003
SGTC_324 1315-0088 19.6 µM -0.611789088451405 0.258517589635835 no 2510 0.270338654972137 3499 6787421
SGTC_1436 4092-1007 8.32 µM -0.612520670133491 0.258267027616768 no 2511 0.270096663246793 3509 2881121
SGTC_1683 st010134 710 nM -0.612914211707634 0.258132294244418 no 2512 0.269966532870033 3539 3818134
SGTC_2854 9024559 71.43 µM -0.613528869141835 0.257921932312254 no 2513 0.269763350038183 3506 3163529
SGTC_3340 9146634 11.102 µM -0.613635798990394 0.257885345451859 no 2514 0.26972801083835 3536 4907387
SGTC_2942 9052777 62.25 µM -0.615001193141084 0.257418402306018 no 2515 0.269276966235561 3599 6469503
SGTC_2461 5755302 26.15 µM -0.615855631441793 0.257126421577967 no 2516 0.268994903453557 3563 2788904
SGTC_1084 voriconazole 435 nM -0.617095976209846 0.256702874618223 no 2517 0.268585711292391 3549 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1608 st001473 40.5 µM -0.617376459210499 0.256607147016717 no 2518 0.268493222792625 3442 7292267
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.619284228832016 0.255956527332533 no 2519 0.267864566126261 3509 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_921 1561-0023 372 µM -0.619428360643231 0.255907408071553 no 2520 0.267817101316331 3555 24050882
SGTC_2199 6590217 200 µM -0.619488964244594 0.255886756195011 no 2521 0.267797144888885 3474 703109
SGTC_2601 securinine 100 µM -0.619502107958415 0.25588227732918 no 2522 0.267792816836198 3485 442872 A GABA receptor antagonist.
SGTC_517 1365-0151 113 µM -0.621918996698588 0.255059391720238 no 2523 0.266997566566522 3588 768657
SGTC_2524 avocatin b 10.57 µM -0.625033345778004 0.254001084350133 no 2524 0.265974586379925 3497 6710748
SGTC_1247 0448-0043 5.84 µM -0.625281153874034 0.253916974125925 no 2525 0.265893273428172 3554 3089013 YGL099W LSG1
SGTC_907 3448-6986 75.5 µM -0.626346190603458 0.253555649275121 no 2526 0.265543947762299 3606 590582
SGTC_1014 4130-3005 69.3 µM -0.62726876620802 0.253242874327332 no 2527 0.26524153677827 3560 743608
SGTC_764 1951-2361 146 µM -0.630430270938229 0.252172590174155 no 2528 0.264206555382737 3505 5438930
SGTC_68 0986-0284 82.829 µM -0.632306939243942 0.251538400013718 no 2529 0.263593165028397 3537 423278 YIL048W NEO1
SGTC_2171 5739187 198.077 µM -0.633970112232491 0.250977062325815 no 2530 0.263050163737586 3499 2262761
SGTC_699 0375-0592 111 µM -0.634192407299148 0.250902085748942 no 2531 0.262977631031975 3601 762578
SGTC_2734 clemastine 41.6 µM -0.634196470905169 0.250900715269859 no 2532 0.262976305212241 3530 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_807 1315-0151 48 µM -0.63569604635295 0.250395243772383 no 2533 0.26248727691889 3633 4011080
SGTC_2485 5633444 17.78 µM -0.636096633344109 0.250260306762076 no 2534 0.262356719863847 3560 5724239
SGTC_3130 9127414 49.47 µM -0.636344409866897 0.250176862988848 no 2535 0.262275982585069 3579 1494646
SGTC_78 0336-0123 156.75 µM -0.637396953295561 0.249822562169859 no 2536 0.261933156206554 3459 6765896
SGTC_2782 7736369 71.43 µM -0.637773236176391 0.249695964765349 no 2537 0.261810652009638 3595 2950836 YOL077C BRX1
SGTC_3247 9135149 49.47 µM -0.637949879409226 0.249636546297644 no 2538 0.261753153452898 3551 8934436 YOR116C RPO31
SGTC_533 1222-0222 6.71 µM -0.638377917506004 0.249492595894981 no 2539 0.261613851056413 3625 3982874
SGTC_2621 lithochol-11-enic acid 100 µM -0.639288005197169 0.249186677524342 no 2540 0.261317795055442 3587 6708711
SGTC_2517 totarol 10 µM -0.639356203817896 0.249163761165507 no 2541 0.261295616642391 3541 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_268 camptothecin 39.6153 µM -0.641296621245124 0.248512204678089 no 2542 0.260664992005995 3603 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_126 0417-1624 672.48 µM -0.642357862747359 0.248156243701473 no 2543 0.260320426208915 3676 41912 YDL195W SEC31
SGTC_2453 5731132 22.18 µM -0.643197282899038 0.247874878642659 no 2544 0.260048048073836 3632 1362040
SGTC_208 k072-0098 12.366 µM -0.643710916672927 0.247702797860792 no 2545 0.259881454795893 3592 5948901
SGTC_2007 4011539 71.82 µM -0.644522700148755 0.247430959255179 no 2546 0.259618271200886 3590 45595301
SGTC_2516 gossypol 71.55 µM -0.644861534435773 0.247317542385236 no 2547 0.259508460425586 3614 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_657 3534-0529 86.7 µM -0.644942340209114 0.247290498643296 no 2548 0.259482276109013 3610 1049549
SGTC_1125 tnp00248 1.32998 µM -0.646518486891889 0.246763316710213 no 2549 0.2589718142806 3640 24207736
SGTC_2221 6807166 181.081 µM -0.646575748343142 0.246744175510348 no 2550 0.258953278971308 3541 674925
SGTC_2683 piperine 63.03 µM -0.647885573393639 0.246306547969037 no 2551 0.258529481144008 3539 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_516 3992-2719 87.3 µM -0.649282822634605 0.245840170069901 no 2552 0.258077793248969 3534 5350887 YDR037W KRS1
SGTC_96 0929-0093 37.281 µM -0.650201738467295 0.245533710248299 no 2553 0.257780959129252 3571 6991579
SGTC_1191 1487-1166 10.6 µM -0.650782510854376 0.245340127672656 no 2554 0.257593445716779 3646 3955771
SGTC_2698 st077697 67.5 µM -0.651829578905903 0.244991327181738 no 2555 0.257255558938492 3543 3154499
SGTC_2826 7992541 19.48 µM -0.652687023017302 0.244705893244739 no 2556 0.256979035107769 3651 2985066
SGTC_2722 naftopidil 47.16 µM -0.65438991067401 0.244139551549907 no 2557 0.256430316451487 3572 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2536 dehydroabietamide 32.04 µM -0.656460738276494 0.243451794899099 no 2558 0.255763860664569 3627 3983547
SGTC_2008 4012253 172 µM -0.65701713658065 0.243267184232116 no 2559 0.255584948880908 3614 603940
SGTC_1254 0550-0035 264 µM -0.65842121988037 0.242801651776344 no 2560 0.255133751870366 3628 15121435
SGTC_1884 5633444 25 µM -0.659106511228696 0.242574614422072 no 2561 0.254913687385969 3632 5724239
SGTC_1775 st081588 35.1725 µM -0.659128244359527 0.242567416106643 no 2562 0.254906709950272 3637 1426443 YGL099W LSG1
SGTC_2294 7971431 200 µM -0.659382020523215 0.242483370471404 no 2563 0.254825242347141 3554 5741572
SGTC_1156 4092-0367 4.88 µM -0.66004714788065 0.242263168341222 no 2564 0.254611786858389 3599 1357585
SGTC_2521 angolensin 13.4 µM -0.660442168346454 0.242132441171898 no 2565 0.254485059558283 3619 821428 A flavenoid.
SGTC_2319 6033012 152.6 µM -0.661411854306629 0.241811697759403 no 2566 0.254174112877124 3565 847246
SGTC_1662 st014054 52 µM -0.665554057782108 0.240444179117254 no 2567 0.252848090009987 3626 2838777
SGTC_2247 cerulenin 830 nM -0.666650807737748 0.240082801566047 no 2568 0.252497603676917 3670 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1292 0kpi-0043 232 µM -0.666750135368296 0.240050087881622 no 2569 0.252465874378548 3606 3333905
SGTC_1371 2421-0008 32.7 µM -0.667000083472449 0.239967777901646 no 2570 0.252386040051738 3603 2827552
SGTC_1912 st060209 90.8 µM -0.667874448686807 0.239679963326013 no 2571 0.252106869371799 3592 688787
SGTC_670 4204-0025 119 µM -0.66793146476522 0.239661201903083 no 2572 0.25208867071858 3625 719039
SGTC_2210 7115885 190.385 µM -0.668661382463969 0.239421089694744 no 2573 0.251855753481232 3634 2927039
SGTC_2438 5259590 200 µM -0.669368315476284 0.239188663773394 no 2574 0.251630279012141 3629 1201127
SGTC_3085 9117376 49.47 µM -0.669872684445417 0.239022912392657 no 2575 0.251469477021575 3647 16480349
SGTC_1066 ketoconazole 628 nM -0.672106950411517 0.238289418639646 no 2576 0.250757806032085 3649 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2894 9048625 32.47 µM -0.673488442447755 0.237836502142202 no 2577 0.250318299564464 3690 4092861
SGTC_2345 9052315 157.45 µM -0.676031742253806 0.237003927736551 no 2578 0.24951024597333 3637 6469265
SGTC_1865 st057639 52.2 µM -0.67691043536881 0.236716651591637 no 2579 0.249231391348133 3641 688818
SGTC_2822 7994718 71.43 µM -0.677299777298829 0.236589423075955 no 2580 0.249107886086945 3607 1018011
SGTC_2705 st078069 42.8 µM -0.678057354232948 0.236341971195512 no 2581 0.248867664342964 3619 1530061
SGTC_1204 4049-0315 18.3 µM -0.679712497494958 0.235801837941732 no 2582 0.248343260604347 3668 588402
SGTC_2358 9037157 4 µM -0.680343590109508 0.235596068905676 no 2583 0.248143464970429 3652 2388925
SGTC_3279 9140807 49.47 µM -0.681604926725769 0.235185104511852 no 2584 0.247744399414018 3681 45595718
SGTC_328 k915-0120 63.5 µM -0.68386586273917 0.234449445842912 no 2585 0.247029936054175 3621 6624543
SGTC_12 0849-0099 9.267 µM -0.684512293734266 0.234239345756565 no 2586 0.246825864524808 3590 6071388
SGTC_558 k064-0027 21.3 µM -0.685548610898222 0.233902744216548 no 2587 0.246498898390238 3674 5088526
SGTC_1213 1315-0166 115 µM -0.685869473986932 0.233798580473516 no 2588 0.246397710657014 3628 768401
SGTC_2697 mebhydrolin 72.4 µM -0.68596971789803 0.233766042952153 no 2589 0.246366102192545 3657 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3300 9124615 50.48 µM -0.688048352082223 0.233091918447518 no 2590 0.245711166547182 3675 24824903
SGTC_303 1348-1668 34.2 µM -0.688308408086137 0.23300765538643 no 2591 0.24562929400033 3672 5380509
SGTC_3061 glucosamine 200 µM -0.689195401801422 0.232720379943491 no 2592 0.245350155031715 3592 91431 and experimental redox chemotherapeutic
SGTC_1627 st003713 25.6 µM -0.690758592272991 0.23221458047523 no 2593 0.244858630686405 3701 16195070 YER133W GLC7
SGTC_673 1082-0474 110 µM -0.69154817867959 0.231959327775541 no 2594 0.244610557396947 3684 3098046
SGTC_1567 st069303 68.4 µM -0.691950336937211 0.231829380573559 no 2595 0.244484258836391 3695 5581319
SGTC_3113 9123498 49.47 µM -0.693209327234521 0.231422832215758 no 2596 0.244089097808302 3695 8897275
SGTC_850 0388-0143 75.9 µM -0.693665448176361 0.231275641539474 no 2597 0.243946019548108 3636 67273
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.693839614942351 0.231219451533315 no 2598 0.24389139800081 3712 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_891 0929-0073 133 µM -0.695487667548704 0.230688130914601 no 2599 0.243374868578204 3688 5603632
SGTC_27 0485-0001 32.618 µM -0.695759673700555 0.230600503661323 no 2600 0.243289673811969 3600 2054479
SGTC_1296 1068-0102 11.9 µM -0.697787242083637 0.229947905367857 no 2601 0.242655129408802 3660 767053
SGTC_2126 5251174 33.877 µM -0.697979137276432 0.229886195087329 no 2602 0.242595120661203 3692 790722
SGTC_1518 st038567 90.8 µM -0.698143820793898 0.229833243018872 no 2603 0.242543627855232 3665 77966
SGTC_105 0111-0055 734.78 µM -0.698536373973434 0.229707049656212 no 2604 0.24242090924228 3648 5179370
SGTC_2370 9071495 200 µM -0.699403377248674 0.22942847322549 no 2605 0.242149988920598 3629 21791103
SGTC_1701 st028638 40.4 µM -0.69981557781721 0.229296095685919 no 2606 0.242021242491966 3659 3490878
SGTC_1983 st071813 46.9 µM -0.701686125327908 0.228695910793884 no 2607 0.241437463794643 3709 11838595
SGTC_2952 9073731 13.78 µM -0.701948309120728 0.228611856901181 no 2608 0.241355700083241 3703 16457353
SGTC_591 4299-0174 154 µM -0.705306073052254 0.227536921551812 no 2609 0.24030989095266 3660 5509088
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.707126840293311 0.226955223788065 no 2610 0.239743828842201 3509 4000243
SGTC_2936 9038235 15.59 µM -0.707919022033199 0.226702400042857 no 2611 0.239497773140563 3682 4749415
SGTC_1929 genistein trimethyl ether 50.5 µM -0.708620230952812 0.226478742819985 no 2612 0.239280089156184 3695 136420
SGTC_429 1112-0049 25.5 µM -0.710027558046971 0.226030238688144 no 2613 0.238843523517687 3672 2836170
SGTC_2322 7413319 38.22 µM -0.711381434580239 0.225599243062896 no 2614 0.238423950214058 3738 1840400
SGTC_2406 ethylparaben 405.7 µM -0.711521961745498 0.225554534034536 no 2615 0.238380423253716 3678 8434 A possible steroid mimic.
SGTC_123 0083-0120 66.675 µM -0.711675803966922 0.225505594541811 no 2616 0.238332777070701 3655 16001701
SGTC_1887 st057648 70.8 µM -0.711848983754723 0.225450510674037 no 2617 0.238279148127671 3696 688672
SGTC_2118 5526350 200 µM -0.712095391660965 0.225372148027039 no 2618 0.238202853876859 3717 743594
SGTC_1848 st056003 16.4 µM -0.712646346871135 0.225196989044445 no 2619 0.238032312345888 3740 146492
SGTC_3307 9126885 69.2785 µM -0.713396930438773 0.224958488598949 no 2620 0.237800086000942 3704 24824909
SGTC_2219 9098279 200 µM -0.713524121834411 0.224918087296799 no 2621 0.237760746012879 3673 902349
SGTC_1825 st052143 62.6 µM -0.715958481317938 0.224145626098831 no 2622 0.237008492987661 3712 674173
SGTC_1816 st051957 91.6 µM -0.716207770317294 0.224066607847856 no 2623 0.23693153291062 3699 674121
SGTC_541 4513-1321 94 µM -0.716848397690996 0.223863617916822 no 2624 0.236733822541314 3699 747515
SGTC_3035 9091303 49.47 µM -0.717645197625257 0.223611288865012 no 2625 0.236488040878241 3743 25237002
SGTC_906 1165-0455 526 µM -0.71790355777121 0.223529506614748 no 2626 0.236408377023788 3686 3252859
SGTC_577 r071-0003 38.6 µM -0.718068221496988 0.223477392244663 no 2627 0.236357611626532 3735 4568517 YMR134W ERG29
SGTC_470 aa-861 153 µM -0.718813746488081 0.223241527785511 no 2628 0.236127843331535 3709 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1210 3013-0140 750 nM -0.719151270830887 0.223134790593164 no 2629 0.236023859941502 3730 905973
SGTC_801 0866-0028 10.1 µM -0.719563998824741 0.223004310830761 no 2630 0.235896742356351 3729 6849771
SGTC_141 0443-0274 32.331 µM -0.719866803484984 0.222908609855885 no 2631 0.235803504460437 3784 1627241
SGTC_2009 4012297 12.05 µM -0.720211527721311 0.222799688743726 no 2632 0.235697383662671 3707 45595307
SGTC_2694 st077685 81.9 µM -0.720355171845661 0.222754311048226 no 2633 0.235653171660417 3689 2838096
SGTC_1873 rapamycin 2 nM -0.720498735193399 0.222708964133314 no 2634 0.235608989091003 3704 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3217 9129673 49.47 µM -0.721104526589684 0.22251767261364 no 2635 0.235422603115602 3704 17248312
SGTC_1451 4152-0210 104 µM -0.722922440226881 0.221944190486243 no 2636 0.234863768017557 3700 659563
SGTC_3121 9125696 49.47 µM -0.723505123157983 0.221760555103052 no 2637 0.23468480385905 3770 1235365
SGTC_1288 0973-0013 65.5 µM -0.727585291006713 0.220477104616932 no 2638 0.233433743671981 3753 4315430
SGTC_1728 st035614 33.7865 µM -0.728504786672561 0.220188458523732 no 2639 0.233152319795104 3733 15945546
SGTC_1853 st056710 91.2 µM -0.728614861691499 0.220153918542082 no 2640 0.233118642499763 3801 269167
SGTC_899 1083-0020 478 µM -0.728944438878076 0.220050520472471 no 2641 0.233017824979215 3750 767123
SGTC_1695 st026914 34.495 µM -0.730193413857335 0.219658933164772 no 2642 0.232635983897903 3686 3289191
SGTC_226 1,3-diallylurea 8.28947 mM -0.730467645590012 0.219573007732881 no 2643 0.232552191388855 3679 74537 YKL182W FAS1
SGTC_1200 1643-0193 18.4 µM -0.730783319580913 0.21947412104277 no 2644 0.232455756825958 3722 5403974
SGTC_1057 3448-5381 134 µM -0.731690537375154 0.219190072320338 no 2645 0.23217873666818 3752 5497911
SGTC_312 4092-0653 6.84 µM -0.73281066334463 0.218839654048137 no 2646 0.231836958326774 3719 1148278
SGTC_1594 piperine 70.1 µM -0.736294622468562 0.217751800966364 no 2647 0.230775709059993 3719 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_482 fipronil 114 µM -0.737357787957576 0.217420453845296 no 2648 0.230452399238145 3770 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_914 3820-6779 408 µM -0.737981423574632 0.217226226536811 no 2649 0.23026286882815 3718 2893481
SGTC_2488 5268135 45.7 µM -0.738961103617806 0.216921313947794 no 2650 0.229965308324824 3777 1270356 YLR208W SEC13
SGTC_630 4356-0227 183 µM -0.740140363629676 0.216554613042287 no 2651 0.229607414555404 3730 779312
SGTC_2630 antimycin a 100 µM -0.740606368501075 0.216409803796121 no 2652 0.229466072738527 3748 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2104 5389443 200 µM -0.741307569866644 0.216192013773025 no 2653 0.229253486455658 3778 2244536
SGTC_1053 3366-3204 134 µM -0.741842182261693 0.216026050845625 no 2654 0.22909147989989 3753 3632071 YPR165W RHO1
SGTC_3072 9116419 49.47 µM -0.742422443146422 0.215846000536159 no 2655 0.228915712930639 3750 17170162
SGTC_2274 7947094 46.08 µM -0.745478160723095 0.214899271815803 no 2656 0.227991354417892 3732 2971028
SGTC_775 4577-0580 57.3 µM -0.745485322054954 0.21489705591388 no 2657 0.227989190574625 3799 2006902
SGTC_1569 carminic acid 40.6 µM -0.745873370673546 0.214777003446106 no 2658 0.227871956419856 3771 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3025 9087895 49.47 µM -0.746401162310964 0.214613780567392 no 2659 0.227712558672992 3768 17173641
SGTC_1467 k284-1082 293 µM -0.748199605209801 0.214058142501039 no 2660 0.227169884554964 3718 3334705
SGTC_2036 5160441 105 µM -0.748898013615431 0.21384259158258 no 2661 0.226959338832618 3744 134534 YIL048W NEO1
SGTC_2217 6934799 96.0675 µM -0.749838038505831 0.213552669812905 no 2662 0.226676128007472 3694 675606
SGTC_59 0330-0160 1.33 µM -0.750191885170263 0.21344359605436 no 2663 0.226569572727528 3730 4293482
SGTC_127 0180-0333 59.125 µM -0.750968473311198 0.213204325476271 no 2664 0.226335814749128 3695 771601
SGTC_1692 fluoroquinolonic acid 71 µM -0.751044940502522 0.213180774025736 no 2665 0.22631280500677 3780 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2216 7189485 200 µM -0.751710635233104 0.212975808027808 no 2666 0.226112546639003 3747 731273
SGTC_1990 st072050 59.8 µM -0.752215759612386 0.212820358060284 no 2667 0.22596065887831 3763 17233948
SGTC_3067 9117431 49.47 µM -0.752571126444081 0.212711035065669 no 2668 0.225853836856431 3792 17150885
SGTC_1833 st055984 71 µM -0.754537584509517 0.212106678302279 no 2669 0.225263242991727 3804 676288
SGTC_724 3910-0327 137 µM -0.754950018158384 0.211980051464608 no 2670 0.225139486271786 3792 2885483
SGTC_2193 5925765 200 µM -0.755406253526434 0.211840027988565 no 2671 0.225002631091436 3751 877370
SGTC_743 1275-0778 158 µM -0.756425995960071 0.211527253934685 no 2672 0.224696913365258 3774 2849257 YMR203W TOM40
SGTC_2917 7979103 53.79 µM -0.757466486016491 0.211208395061796 no 2673 0.224385218494509 3811 2980565
SGTC_276 colchicine 750 µM -0.757506414157556 0.211196164670052 no 2674 0.224373262294526 3801 2833 A microtubule depolymerizer.
SGTC_1071 trifluoperazine 6.31 µM -0.757792990681317 0.21110839557341 no 2675 0.224287459589879 3853 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_297 0986-0032 24 µM -0.760575867986549 0.210257202844084 no 2676 0.223455219054098 3752 2847425
SGTC_1484 3473-2379 286 µM -0.760602847130187 0.210248960667731 no 2677 0.223447159344781 3875 671917
SGTC_3087 9117406 49.47 µM -0.761035131264927 0.21011692297473 no 2678 0.223318041980974 3739 42546093
SGTC_3053 9095903 49.47 µM -0.765416324666278 0.20878147384857 no 2679 0.222011837576679 3846 17174018
SGTC_1342 1486-1464 234 µM -0.766169428330004 0.208552422120265 no 2680 0.221787748199367 3808 3253938
SGTC_63 0099-0242 26.702 µM -0.766317601651971 0.208507373588215 no 2681 0.221743673778555 3830 3898502 YLR359W ADE13
SGTC_2791 5663188 71.43 µM -0.766372708585722 0.208490621115303 no 2682 0.221727283398741 3754 54690634
SGTC_2504 purpurogallin 52.29 µM -0.767111007224595 0.208266255355832 no 2683 0.221507759013339 3717 5281571 An antioxidant.
SGTC_1322 1348-1070 12 µM -0.767432853188651 0.208168492362637 no 2684 0.221412100813843 3745 6758089
SGTC_1354 1498-1681 81 µM -0.768467582405381 0.20785436957277 no 2685 0.221104721441534 3840 5754243
SGTC_1635 st007035 42.4 µM -0.770315772736831 0.207293993534317 no 2686 0.220556301191829 3777 3716403
SGTC_360 0957-0399 1.01 µM -0.770740675908154 0.207165288218646 no 2687 0.220430328405477 3805 6752301 YPR165W RHO1
SGTC_2253 7938677 135.83 µM -0.770914958965691 0.207112510673439 no 2688 0.220378669921084 3826 2301972
SGTC_2528 xanthyletin 44.79 µM -0.772088914505618 0.206757212997876 no 2689 0.220030883710553 3853 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_787 4152-0075 138 µM -0.772109082672806 0.20675111225619 no 2690 0.220024911611208 3797 9566539
SGTC_131 0141-0277 33.849 µM -0.773495231671418 0.206332066482774 no 2691 0.219614674823469 3743 1547771
SGTC_2348 9022543 33.42 µM -0.775718046257436 0.205661140630132 no 2692 0.218957741080688 3820 3162678 YDL140C RPO21
SGTC_2663 amphotericin b 100 µM -0.775729978767954 0.205657542464652 no 2693 0.218954217582688 3789 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2703 st077852 53.4 µM -0.775805784610927 0.205634684613136 no 2694 0.21893183397397 3787 6281836
SGTC_590 k048-0076 22.4 µM -0.775953721795578 0.205590081231422 no 2695 0.218888155537908 3786 6832814
SGTC_1 0258-0098 57.368 µM -0.776269607794632 0.205494860145284 no 2696 0.218794907017353 3728 6790032 YDR047W HEM12
SGTC_2433 5607874 27.82 µM -0.776379257663661 0.205461813269862 no 2697 0.218762544077559 3792 2252428
SGTC_681 1642-0006 26.6 µM -0.776461338640378 0.205437077323049 no 2698 0.218738319844265 3818 4446530
SGTC_1328 1441-0025 69.2 µM -0.778082234850439 0.204948965956736 no 2699 0.218260267516137 3751 4562601
SGTC_1131 3454-3128 32.3 µM -0.780736979674965 0.204151015847384 no 2700 0.217478603109156 3886 710982
SGTC_2462 5162487 171.77 µM -0.781337213555698 0.203970857323082 no 2701 0.217302094197109 3715 2259986
SGTC_548 1436-0017 110 µM -0.78344390506559 0.203339289889309 no 2702 0.216683241118009 3856 9677137
SGTC_1389 3405-0187 19 µM -0.784154612895725 0.203126489498817 no 2703 0.216474696662004 3772 799890
SGTC_3058 9093861 49.47 µM -0.784203084146952 0.203111981064203 no 2704 0.2164604778753 3813 17217477
SGTC_2878 9043973 25.97 µM -0.784689111048778 0.20296653750094 no 2705 0.216317934320759 3904 6465167
SGTC_2931 9014674 55.67 µM -0.784696454877377 0.202964340337159 no 2706 0.216315780915568 3827 2996810
SGTC_1676 st018489 23.4 µM -0.785001539009988 0.202873076276425 no 2707 0.216226333128127 3862 3696235
SGTC_2526 patulin 37.61 µM -0.788287915092615 0.201891532026131 no 2708 0.215264157428453 3883 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1490 4089-0339 670 nM -0.78885483174162 0.201722498616519 no 2709 0.215098428855794 3764 742542
SGTC_3273 9137859 49.47 µM -0.789301815805516 0.201589284410981 no 2710 0.214967812805501 3882 2377234
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.789422591512839 0.201553298796025 no 2711 0.214932528075614 3852 688664
SGTC_689 0833-0039 98 µM -0.790716531151262 0.201168005748406 no 2712 0.214554713584313 3797 5374726
SGTC_2490 carminic acid 95.39 µM -0.791907142644545 0.200813870920221 no 2713 0.214207410949204 3733 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1250 0485-0349 40.2 µM -0.79367844948224 0.20028770727666 no 2714 0.213691324603042 3827 6842794 YDL195W SEC31
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.794000887115181 0.200192016929023 no 2715 0.213597457452829 3820 6708739 YPR165W RHO1
SGTC_3167 9103034 49.47 µM -0.794053147349918 0.20017651016091 no 2716 0.213582245860863 3842 5127859
SGTC_878 0828-0289 13.7 µM -0.79471878494713 0.199979063916332 no 2717 0.213388551336284 3811 745350 YLR208W SEC13
SGTC_2306 7482397 179.52 µM -0.795859562737809 0.199640950580987 no 2718 0.21305683354104 3806 891448
SGTC_172 1112-0046 2.638 µM -0.796638934375915 0.199410151753107 no 2719 0.212830379270727 3789 2802135 YIL048W NEO1
SGTC_925 2064-1272 59.6 µM -0.796677197676953 0.199398824808035 no 2720 0.212819265102968 3819 6815817
SGTC_1468 k284-1086 134 µM -0.798691804816374 0.198802995270574 no 2721 0.212234569946786 3826 15996457
SGTC_2688 kanamycin b 96.69 µM -0.799014295667337 0.198707716842722 no 2722 0.212141061372656 3929 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.799696135327014 0.198506361145297 no 2723 0.211943436311177 3833 676296 Flavone; oxidizing agent.
SGTC_2043 5101342 149 µM -0.802051643709112 0.197811698021107 no 2724 0.211261542634021 3843 678451
SGTC_1774 st048371 48.465 µM -0.802076532650754 0.197804365872198 no 2725 0.211254344429232 3813 4242727
SGTC_1308 1187-1617 41.4 µM -0.802140785221068 0.197785438168261 no 2726 0.211235762416708 3830 2882570
SGTC_3146 9095609 49.47 µM -0.802152836344831 0.197781888236012 no 2727 0.211232277306637 3904 17173999
SGTC_1230 0170-0365 3.77 µM -0.802731874807908 0.197611364672692 no 2728 0.211064862684897 3917 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_278 4092-0821 23.9 µM -0.80345126949099 0.197399630830973 no 2729 0.210856975913545 3849 877900
SGTC_897 1000-0139 31.4 µM -0.805925889313517 0.196672343553668 no 2730 0.210142791238018 3811 6151020
SGTC_1327 1436-0082 2.18 µM -0.806711899209836 0.196441676430137 no 2731 0.209916243483086 3837 15992205
SGTC_2895 9054447 58.44 µM -0.807770071074179 0.196131398112734 no 2732 0.209611478635296 3867 2697450
SGTC_912 3474-0017 2.18 µM -0.807822897276705 0.196115916148694 no 2733 0.209596270945395 3872 3360550
SGTC_1520 flindersine 88 µM -0.808005026423699 0.196062544591424 no 2734 0.209543844297182 3978 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_888 0916-0002 6.97 µM -0.808351491114017 0.195961040079932 no 2735 0.209444134262001 3934 2802138 YIL048W NEO1
SGTC_1842 st055362 61.2 µM -0.809023154217232 0.195764352318932 no 2736 0.209250914008575 3828 676032
SGTC_1504 k297-0033 30 µM -0.809909332298685 0.195505030064257 no 2737 0.208996143905663 3763 4388117
SGTC_1184 1269-1718 139 µM -0.81024853223308 0.195405825235414 no 2738 0.20889867462703 3908 5403821
SGTC_1718 roemerine 11.9335 µM -0.810869411033212 0.195224317827224 no 2739 0.208720334164888 3702 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3259 9138485 49.47 µM -0.813283346415913 0.194519603173936 no 2740 0.208027811480168 3913 17646153
SGTC_2435 5706476 10.6 µM -0.813345113790119 0.194501591392204 no 2741 0.208010109141696 3861 5725375
SGTC_1568 digitonin 820 nM -0.8134617444222 0.194467583883643 no 2742 0.207976685588145 3832 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1355 1499-0035 1.68 µM -0.814350352500073 0.194208599736663 no 2743 0.207722135860895 3829 1548538
SGTC_3292 9120825 59.784 µM -0.817526160195021 0.193284731220467 no 2744 0.206813902838445 3827 24824900
SGTC_655 k060-0012 42 µM -0.817726650058838 0.193226497220872 no 2745 0.206756644763017 3861 5994525
SGTC_451 chloral hydrate 100 µM -0.818830690140843 0.192906011206336 no 2746 0.206441509172787 3927 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3228 9131799 49.47 µM -0.819423047651308 0.192734192755839 no 2747 0.206272544880605 3867 17015818
SGTC_555 4296-0685 37 µM -0.819702677726699 0.192653116118991 no 2748 0.206192811574404 3805 2908540 YHR072W ERG7
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.821095612253011 0.192249555829446 no 2749 0.205795904560019 3941 4213774
SGTC_993 3909-8757 62.7 µM -0.824252410905371 0.191336885404448 no 2750 0.204898076323812 3837 4288324 YLR208W SEC13
SGTC_2727 riluzole 51.77 µM -0.825447549247681 0.190992049914688 no 2751 0.204558774540292 3869 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3351 9150312 21.596 µM -0.827895413209408 0.190286954045577 no 2752 0.203864866399547 3821 4904905
SGTC_383 2324-0395 7.37 µM -0.828861254038739 0.190009188564407 no 2753 0.203591461137589 3897 3146421
SGTC_1111 tnp00062 510.699 nM -0.833444529422852 0.18869448802078 no 2754 0.202297034917911 3942 676306
SGTC_2137 5261020 140 µM -0.833789083200692 0.188595880800539 no 2755 0.202199924063232 3850 763655
SGTC_1667 st014849 34.6 µM -0.833836545377344 0.18858230017638 no 2756 0.202186549258744 3915 5348460
SGTC_1795 st049545 62.3 µM -0.835624926882884 0.188071019815912 no 2757 0.201682970547351 3821 5291882
SGTC_3202 9113761 49.47 µM -0.836193642739533 0.187908609121568 no 2758 0.201522987119695 3936 4798415
SGTC_2255 7941087 197.44 µM -0.836983639091892 0.187683150126921 no 2759 0.201300882282478 3918 935561
SGTC_69 0096-0274 206.684 µM -0.838041655386014 0.187381462161911 no 2760 0.201003654511985 4011 6741392
SGTC_806 3966-4455 5.86 µM -0.838918738666302 0.187131593719354 no 2761 0.200757455823881 3872 714982
SGTC_607 4491-0986 66.8 µM -0.84075663272016 0.186608672814716 no 2762 0.200242143374079 3906 698981 YDR232W HEM1
SGTC_1827 berberine 7.24 µM -0.841634337628609 0.186359266176526 no 2763 0.199996331383633 3837 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2113 5491891 107.031 µM -0.843640627577261 0.185789939361879 no 2764 0.199435127115593 3910 789979
SGTC_1348 1493-0373 93.8 µM -0.844278412740545 0.185609180681859 no 2765 0.19925692308769 3898 3010129
SGTC_2653 dihydrofissinolide 100 µM -0.844579769693662 0.18552380919972 no 2766 0.199172754088437 3934 6857746
SGTC_698 k064-0052 127 µM -0.844605287279698 0.185516581436073 no 2767 0.199165628010101 3943 5088751
SGTC_225 nsc-122657 1.016 µM -0.844892690590671 0.185435187560254 no 2768 0.199085377948256 3901 275685
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.845381041052499 0.185296935414634 no 2769 0.198949063190003 3891 75037 A free radical scavenger.
SGTC_2842 9000675 19.48 µM -0.846465196243166 0.184990239626869 no 2770 0.198646640755989 3952 2989072
SGTC_1020 4335-0961 93.3 µM -0.849354777346558 0.184174350138664 no 2771 0.197841954449702 3839 669075
SGTC_1630 st005209 31.3 µM -0.85058634298911 0.18382729241506 no 2772 0.197499589253757 3843 3367314
SGTC_1299 1079-1439 3.74 µM -0.85067546594275 0.183802193199631 no 2773 0.197474827706977 3855 323161
SGTC_3291 9121177 71.43 µM -0.852305404607934 0.183343538966404 no 2774 0.197022303562333 3921 17015612
SGTC_36 0335-0881 14.2 µM -0.852854142065818 0.183189288485087 no 2775 0.196870097475531 3823 23828853
SGTC_2323 6148992 148.28 µM -0.853034100273058 0.183138719737937 no 2776 0.196820197062922 3883 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1458 k015-0034 6.33 µM -0.853115707797061 0.183115790671023 no 2777 0.196797570726993 3941 3598957
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.854557747437677 0.182710919757429 no 2778 0.196398013631612 3892 7104
SGTC_1075 aripiprazole 15.2 µM -0.854824167990816 0.182636180022119 no 2779 0.196324248272217 3933 60795 An atypical antipschotic. YIL048W NEO1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.855366685202243 0.18248404511502 no 2780 0.19617409040628 3899 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_934 2950-0684 338 µM -0.855617666677726 0.182413690646975 no 2781 0.196104647344065 3977 1121253
SGTC_1511 0906-3109 28.5 µM -0.85618318874321 0.182255227105454 no 2782 0.195948229954819 3943 2882180
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.857516160627346 0.181882058838965 no 2783 0.195579843700297 3935 6708760
SGTC_1956 st077085 54 µM -0.858191575704838 0.181693157522146 no 2784 0.195393343509204 3955 24208685
SGTC_2189 6047310 154.431 µM -0.859286300028071 0.181387243864146 no 2785 0.195091290350849 3865 711535
SGTC_3135 9127742 49.47 µM -0.86197632556901 0.180636904346661 no 2786 0.194350272861299 3999 3643468
SGTC_929 2805-0021 398 µM -0.862776508751616 0.180414082208914 no 2787 0.194130178669947 3989 3098024
SGTC_386 1509-0011 3.07 µM -0.863003319725796 0.180350954917493 no 2788 0.194067820860133 3947 3107280
SGTC_2051 5263410 176 µM -0.864254302373476 0.180003023551455 no 2789 0.193724103831321 3951 227584
SGTC_1413 3910-0535 34.4 µM -0.86814567310217 0.178923427431764 no 2790 0.192657295238723 3924 2876951
SGTC_2295 7971645 200 µM -0.869212248627261 0.178628236762174 no 2791 0.19236552453345 3989 2978226 YKL099C UTP11
SGTC_3204 9114183 49.47 µM -0.869915444728605 0.178433784613725 no 2792 0.192173307210509 3936 17027248
SGTC_1329 1447-1697 50.6 µM -0.870502126543192 0.178271653798742 no 2793 0.192013028792209 3948 2840515
SGTC_826 1683-5028 118 µM -0.872296386312093 0.177776382518588 no 2794 0.191523354268381 3994 722377
SGTC_359 0081-0058 15.9 µM -0.875154491250204 0.176989251527784 no 2795 0.190744925576538 3964 3494159
SGTC_2281 7943571 200 µM -0.876998319116653 0.176482626029218 no 2796 0.190243775529241 4042 1244024
SGTC_2135 5326629 150.42 µM -0.877780687443661 0.176267933461859 no 2797 0.19003137348225 3913 5020077
SGTC_685 1278-0033 54.9 µM -0.879228999379246 0.175870933244669 no 2798 0.189638561908113 3954 3590572
SGTC_3159 9100096 49.47 µM -0.880730584180181 0.175459928697579 no 2799 0.189231829460691 3910 25236875
SGTC_1466 k213-0079 57.5 µM -0.881021458707158 0.175380382762013 no 2800 0.189153102775024 3877 3657981
SGTC_2149 5554786 194.827 µM -0.881783098236981 0.175172204277425 no 2801 0.1889470566897 3969 745063 YPR165W RHO1
SGTC_2780 5215298 71.43 µM -0.883386378211301 0.174734493161723 no 2802 0.188513774022163 3981 2834131
SGTC_709 3807-1509 243 µM -0.885152247632491 0.174253197794318 no 2803 0.18803726161181 4008 1886677 YPL242C IQG1
SGTC_961 1252-1571 372 µM -0.886361089493938 0.173924208912474 no 2804 0.187711489837737 3936 6813498
SGTC_1629 st005085 44.9 µM -0.88656321417907 0.173869238816071 no 2805 0.187657053132594 3930 24207091
SGTC_725 1497-0963 19 µM -0.887669989477159 0.173568434667056 no 2806 0.18735914669999 4034 3549977
SGTC_3030 9087619 49.47 µM -0.887821642889867 0.173527243462954 no 2807 0.187318349523015 3977 25236973
SGTC_1209 2323-2347 50.3 µM -0.887833417342034 0.17352404561609 no 2808 0.187315182238126 3939 5412760
SGTC_2273 7815444 169.05 µM -0.891340514561573 0.172573215632493 no 2809 0.186373259882456 3902 2824616
SGTC_580 1123-0028 41 µM -0.892870959406957 0.17215933083098 no 2810 0.185963140274188 4014 1677248 YPR107C YTH1
SGTC_1278 0874-0585 172 µM -0.896527015446295 0.171173174497835 no 2811 0.184985679192313 4025 766306
SGTC_2903 5923464 63.88 µM -0.898405234242768 0.170667965623081 no 2812 0.184484773485407 3976 2876576
SGTC_1201 1889-3372 45.9 µM -0.898990610574788 0.170510704656765 no 2813 0.184328830972991 3846 5392199
SGTC_1443 4112-3303 14 µM -0.900607356494224 0.170076849145634 no 2814 0.183898560913417 3983 704433
SGTC_1203 3992-3522 103 µM -0.90101267122815 0.169968193515139 no 2815 0.183790791270731 4105 5322312
SGTC_3256 9138902 49.47 µM -0.901330382668024 0.169883053447031 no 2816 0.183706342088938 4029 17228773
SGTC_1614 st002383 48.6 µM -0.902723123235665 0.169510150629473 no 2817 0.18333643049691 3968 1947235
SGTC_1012 4112-3522 18 µM -0.903034349504343 0.169426892421325 no 2818 0.183253832398432 3993 3112398
SGTC_2376 9072922 81.32 µM -0.903560549026442 0.16928618499488 no 2819 0.183114234130325 4019 17087968
SGTC_2389 9091542 195.52 µM -0.906060053828441 0.168618834272614 no 2820 0.182452033557036 3969 3626624 YOL127W RPL25
SGTC_22 0964-0034 14.468 µM -0.908646904367068 0.167929946097051 no 2821 0.181768269675214 4022 138402
SGTC_1100 amiodarone 5.07 µM -0.911843524385606 0.167081180189827 no 2822 0.180925547358341 4072 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1938 st074717 56.4 µM -0.912159018551674 0.16699756047572 no 2823 0.180842506853636 3822 17250979
SGTC_3138 9097216 49.47 µM -0.914809100521078 0.166296238888215 no 2824 0.180145928206007 3964 25237486
SGTC_1335 1486-0900 202 µM -0.915846457526271 0.166022229965779 no 2825 0.179873716415663 3981 X1335
SGTC_2799 7812892 81.82 µM -0.916639561569467 0.165812935261317 no 2826 0.179665773156218 4025 20205235
SGTC_1034 k072-0165 12.7 µM -0.920245078847616 0.164863615284403 no 2827 0.178722351088013 4046 5835461
SGTC_2684 capsaicin 100 µM -0.924762414056954 0.16367919502996 no 2828 0.177544752790177 4027 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1412 3909-8563 178 µM -0.925290663837788 0.163541052519183 no 2829 0.177407366903447 4077 23767530
SGTC_2940 9060638 45.86 µM -0.926809681617381 0.163144236446658 no 2830 0.177012678658797 4001 4027022
SGTC_2816 7982706 58.44 µM -0.929853509944536 0.162350975867258 no 2831 0.176223468254152 4069 2981853
SGTC_237 nikkomycin 200 µM -0.932090078972652 0.161769700252036 no 2832 0.175644987380153 4032 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1304 1165-0502 251 µM -0.933211788415895 0.161478683617662 no 2833 0.175355314679488 4013 767425
SGTC_147 4466-0538 29.23 µM -0.934599194536259 0.161119207077874 no 2834 0.174997447143983 4090 6742687 YHR072W ERG7
SGTC_1870 st057514 26.5 µM -0.935394638554247 0.160913343443924 no 2835 0.174792479461878 4001 5393161
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.935519156788375 0.16088113324835 no 2836 0.17476040776811 4057 5282309
SGTC_2112 5488546 200 µM -0.936155380676597 0.160716621479077 no 2837 0.174596596281493 3983 600757
SGTC_1843 st055809 45.5 µM -0.936163842560762 0.160714434185538 no 2838 0.174594418218555 4080 16413835
SGTC_1232 0279-0259 161 µM -0.940839824182672 0.159508723612016 no 2839 0.173393474564829 4029 1560000
SGTC_2303 7774051 200 µM -0.944525344111866 0.158562588828073 no 2840 0.172450628466852 4047 2953184
SGTC_2871 9038510 12.99 µM -0.946731835169854 0.157997910458781 no 2841 0.171887721985462 3952 4945164
SGTC_2676 harmalol 100 µM -0.95231044748921 0.15657614495897 no 2842 0.170469780449335 3978 5459187 A monoamine oxidase inhibitor
SGTC_2223 6903751 107.57 µM -0.953266596205946 0.156333309012401 no 2843 0.170227505813384 3993 5598863
SGTC_2732 terfenadine 20 µM -0.954175120667928 0.15610279830055 no 2844 0.169997503000465 4060 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1980 st071811 45.7 µM -0.955587205304716 0.155744969166197 no 2845 0.169640414090219 4135 4974850
SGTC_3103 9120822 49.47 µM -0.956922240910724 0.155407162439356 no 2846 0.169303252215866 4069 17141819
SGTC_1228 0124-0032 52.5 µM -0.957465594830636 0.155269815042241 no 2847 0.169166151986249 4108 X1228
SGTC_2222 6885208 172.143 µM -0.958550090290758 0.15499591909833 no 2848 0.168892722957999 3977 609514
SGTC_2872 9044037 25.97 µM -0.959120754537848 0.154851922558252 no 2849 0.16874895798846 4042 6465195
SGTC_957 1187-1561 14.1 µM -0.960264085247759 0.154563690220833 no 2850 0.1684611603327 4011 1538454
SGTC_790 1575-0012 79.1 µM -0.960339008789496 0.154544814471096 no 2851 0.168442311705452 4107 378741 YLR208W SEC13
SGTC_2750 bromebric acid 70.15 µM -0.96171799607977 0.154197673476901 no 2852 0.168095640002669 4104 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_619 1652-1634 108 µM -0.96394102570737 0.153639143140431 no 2853 0.167537746906623 4012 5400454
SGTC_2332 7982454 138.89 µM -0.966122186857332 0.153092435670802 no 2854 0.166991521838116 3979 2981748
SGTC_989 1501-0895 10.3 µM -0.967745084621614 0.152686494422648 no 2855 0.166585847909509 4014 2830112
SGTC_1051 3253-3903 78 µM -0.968074420723417 0.152604203630363 no 2856 0.166503601837055 4032 5509239
SGTC_2830 7992007 71.43 µM -0.968932567711956 0.152389917784567 no 2857 0.166289417430708 3937 1952075
SGTC_1810 st050138 53 µM -0.969402552236447 0.152272643746361 no 2858 0.166172189712327 4054 3444541
SGTC_1764 st044502 93.5 µM -0.970207629717496 0.152071894073966 no 2859 0.165971504207425 4104 8407
SGTC_1267 0828-0272 9.49 µM -0.972790451224067 0.151429042933657 no 2860 0.165328729718329 4148 745334
SGTC_2456 5770359 74.46 µM -0.973595165544646 0.151229123374023 no 2861 0.165128793845878 4088 3118787
SGTC_510 ag-490 170 µM -0.974524310506134 0.150998509323182 no 2862 0.164898137241046 4167 5328779
SGTC_942 3253-1115 227 µM -0.974717663715742 0.150950548434371 no 2863 0.164850164303521 4121 46497897
SGTC_2250 alverine citrate 130 µM -0.975142220416583 0.150845273544203 no 2864 0.164744859099568 3952 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1776 st049249 45.9 µM -0.975250115103331 0.150818527308196 no 2865 0.164718104315189 4092 1822314
SGTC_1973 st070275 50.2 µM -0.976636603007321 0.150475108933077 no 2866 0.16437454564994 4009 17118334
SGTC_3022 9087993 49.47 µM -0.98049749117516 0.149521554745878 no 2867 0.163420303715904 4126 17173644
SGTC_2719 novobiocin 32.65 µM -0.980848607649438 0.149435037216672 no 2868 0.163333701997736 4073 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1077 5-fluorocytosine 377 nM -0.981202902404446 0.149347770414762 no 2869 0.163246346593054 4096 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_130 0136-0219 337.655 µM -0.981386505446922 0.149302560297333 no 2870 0.163201089117232 3908 234244
SGTC_2808 7946468 45.46 µM -0.981422457635642 0.149293708558232 no 2871 0.163192227989383 4074 2970879
SGTC_1940 st075990 51.1 µM -0.982331479677637 0.14907001591876 no 2872 0.162968285423365 4171 1084979
SGTC_1756 st041558 35.5 µM -0.982469914931522 0.149035969349804 no 2873 0.162934198677068 4170 3955792
SGTC_634 1611-4317 11.2 µM -0.98326218084774 0.148841220535895 no 2874 0.162739209175282 4069 2843522
SGTC_3275 9138069 49.47 µM -0.983266744858473 0.148840099138184 no 2875 0.162738086338023 4153 17617007
SGTC_1164 k060-0068 93.7 µM -0.984082921201566 0.148639651766838 no 2876 0.162537371774728 4073 5963676
SGTC_1260 0700-1617 7.75 µM -0.985366503765512 0.148324777836821 no 2877 0.162222038400378 4088 2853078
SGTC_1112 tnp00069 1.16933 µM -0.986132958535097 0.148136972746269 no 2878 0.16203393611474 4085 145826
SGTC_682 0kpi-0099 17 µM -0.986937570228959 0.147939989303534 no 2879 0.161836622316619 4109 1714895 YML126C ERG13
SGTC_2343 7990716 14.84 µM -0.987053130215288 0.147911712542935 no 2880 0.161808296565813 4068 6456862
SGTC_2080 5212524 12.4 µM -0.987716959889751 0.147749347926633 no 2881 0.161645643019675 3958 260183
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.987818879010327 0.147724430329612 no 2882 0.161620679930555 4093 5024745
SGTC_1503 4585-0012 61.3 µM -0.992176407818158 0.146661716224685 no 2883 0.160555739468371 4138 2922052
SGTC_3325 9138760 55.175 µM -0.994965461979684 0.14598422085942 no 2884 0.15987653129521 4016 43844959
SGTC_2394 5221648 200 µM -0.998439503686647 0.145143278947158 no 2885 0.159033142972242 4147 788586
SGTC_980 1473-0395 201 µM -0.99895832583181 0.145017970910447 no 2886 0.158907439864034 3967 768876
SGTC_1553 gossypol 38.6 µM -1.00058454636021 0.144625671477394 no 2887 0.158513852165186 3951 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.00291283153572 0.144065255800891 no 2888 0.157951460483806 4139 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2789 5281112 71.43 µM -1.00315663210459 0.144006658085838 no 2889 0.157892646909689 4115 765948
SGTC_1645 Cervolide 78 µM -1.0059971704961 0.1433251164828 no 2890 0.157208465581466 4072 23173 A fragrance.
SGTC_1605 st000082 49.1 µM -1.00914019853467 0.142573539669952 no 2891 0.156453700837153 4081 1114022
SGTC_2159 5658611 73.75 µM -1.01065064822775 0.142213303131894 no 2892 0.156091832737053 4091 793844
SGTC_663 1486-0733 13.9 µM -1.01079051847158 0.142179975794569 no 2893 0.156058351051781 4120 722445 YPR165W RHO1
SGTC_1197 1601-0112 267 µM -1.01335209103951 0.141570556317253 no 2894 0.155446007218579 4066 7350313
SGTC_741 4582-0002 126 µM -1.01462384480021 0.141268653878859 no 2895 0.155142584237271 4083 2912688
SGTC_1046 2001-0062 216 µM -1.01617931406587 0.14089999378959 no 2896 0.154772002570413 4012 739778
SGTC_2069 5228469 200 µM -1.01790923145811 0.140490755114679 no 2897 0.154360547067294 4121 2835210
SGTC_817 1391-0715 46 µM -1.01800108159304 0.140469049129664 no 2898 0.154338721035046 4105 1353946
SGTC_2990 9074105 71.4286 µM -1.01877357926583 0.140286582908175 no 2899 0.154155235821058 4022 6502001
SGTC_815 1582-0027 36.9 µM -1.01913921114173 0.140200275734658 no 2900 0.154068440525371 4152 3128206
SGTC_1036 k216-0215 33.5 µM -1.02086235821416 0.13979401354157 no 2901 0.153659827621471 4095 622330
SGTC_2979 9012552 45.46 µM -1.02203797378222 0.139517301194742 no 2902 0.153381463951097 4136 17100905
SGTC_564 3555-0129 330 µM -1.02264487818028 0.139374596022144 no 2903 0.153237891218894 3943 563260
SGTC_2988 9073640 71.4286 µM -1.02373957538031 0.139117444292509 no 2904 0.15297914871414 4181 9102229
SGTC_2293 7624732 200 µM -1.02436535519327 0.138970589563552 no 2905 0.152831369655031 3994 894453
SGTC_666 0272-0154 136 µM -1.02539065503424 0.138730205764886 no 2906 0.152589447891454 4127 6870312
SGTC_3352 9151559 45.5865 µM -1.02549815155914 0.138705019381884 no 2907 0.152564098572213 4125 17159339
SGTC_2195 6536160 144.242 µM -1.02727843487084 0.138288352789381 no 2908 0.152144686960687 4066 3834386
SGTC_508 roscovitine 141 µM -1.02834793843118 0.138038451387729 no 2909 0.151893094300048 4189 160355 A CDKinase inhibitor.
SGTC_2817 7995342 71.43 µM -1.03340522596708 0.136860932839787 no 2910 0.150707150931796 4122 18879975
SGTC_1896 st058441 89 µM -1.03364736299973 0.136804727370547 no 2911 0.150650524436936 4132 688759
SGTC_2869 9037858 32.47 µM -1.0348409027254 0.136527910453892 no 2912 0.150371608694438 4083 27187042
SGTC_2241 6772625 37.8075 µM -1.03671956092703 0.136092970945794 no 2913 0.149933286514044 3981 2285411
SGTC_2930 9013230 14.89 µM -1.03702252381189 0.136022919082097 no 2914 0.149862680099804 4137 2995857
SGTC_2875 9039966 71.43 µM -1.03908225655591 0.135547316744227 no 2915 0.149383241126079 4146 6463691
SGTC_1982 st072467 71.9 µM -1.04171386188371 0.134941325826542 no 2916 0.148772180145021 4108 3163533
SGTC_1609 st001574 46.4 µM -1.04188138889044 0.134902811687808 no 2917 0.14873333687262 4113 3960012
SGTC_2132 5317594 122.667 µM -1.04254999062859 0.13474917653189 no 2918 0.148578380552725 4087 794577
SGTC_2603 homopterocarpin 100 µM -1.04792696188311 0.133517990474196 no 2919 0.147336129506209 4131 101795 A weak amylase inhibitor.
SGTC_544 k015-0020 52.4 µM -1.04998674699904 0.133048409317867 no 2920 0.146862103025325 4147 3008304
SGTC_2761 levamisole 97.89 µM -1.05064423840614 0.132898756826706 no 2921 0.146711007561704 4130 26879 An alkaline phosphatase inhibitor.
SGTC_1771 st048882 4.1505 µM -1.05311689450687 0.132336990033236 no 2922 0.146143710362562 4160 4580403
SGTC_1229 0139-0193 12.2 µM -1.05480159136166 0.131955179718769 no 2923 0.14575803832855 4235 3090752
SGTC_706 4262-0057 46.9 µM -1.05664885724389 0.131537399728627 no 2924 0.145335936944448 4152 883298
SGTC_598 3937-0236 20.2 µM -1.06128286823967 0.130493386926545 no 2925 0.144280684496926 4213 1379313
SGTC_861 0443-0273 110 µM -1.06181672361812 0.130373481902061 no 2926 0.144159448084741 4153 6149169
SGTC_1297 1068-0111 14.1 µM -1.06558303227595 0.129529726621686 no 2927 0.143306086381496 4132 767057
SGTC_2671 danthron 100 µM -1.06755787732074 0.129088822900897 no 2928 0.142859996509896 4145 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2208 7283366 200 µM -1.06765815286849 0.129066463184585 no 2929 0.142837370731257 4137 898663
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.06864220326768 0.128847179413404 no 2930 0.142615461998095 4133 688803
SGTC_2099 5377090 177.372 µM -1.06888224393005 0.128793728476137 no 2931 0.142561366906283 4168 2243829
SGTC_3196 9111891 49.47 µM -1.0705090017952 0.128431896326943 no 2932 0.142195129639537 4155 18891510
SGTC_3184 9108758 49.47 µM -1.07139624288945 0.128234849100493 no 2933 0.141995650739609 4187 902885
SGTC_115 0527-0192 112.043 µM -1.07175429006105 0.128155389950396 no 2934 0.141915204475599 4156 4233931
SGTC_400 oxethazaine 37.5 µM -1.07196500644432 0.128108642980264 no 2935 0.141867875013049 4161 4621 A local anesthetic.
SGTC_1748 st037455 53.6035 µM -1.0755559239544 0.127313826148357 no 2936 0.141062954280785 4220 580690
SGTC_1908 st060353 56.5 µM -1.07690229113722 0.127016706058932 no 2937 0.140761959717821 4237 4227716
SGTC_2075 5212009 200 µM -1.07752774961736 0.126878842422178 no 2938 0.140622280244933 4086 780898
SGTC_3220 9131269 49.47 µM -1.07866735526583 0.126627918288028 no 2939 0.140368021642617 4189 17722206
SGTC_341 1486-1430 230 µM -1.08033354806271 0.126261669942644 no 2940 0.139996837821803 4130 2054753 YPL210C SRP72
SGTC_1027 k015-0025 8.67 µM -1.08096352249176 0.126123386837324 no 2941 0.139856670050593 4140 3598955
SGTC_1563 conessine 56.1 µM -1.08149838086262 0.12600606516505 no 2942 0.139737740266673 4254 441082 An anti-amoebic, histamine inhibitor.
SGTC_1153 4055-0057 267 µM -1.08295001160743 0.125688032226493 no 2943 0.139415305858052 4223 882706
SGTC_1857 st056007 79.3 µM -1.08382425174177 0.125496768281126 no 2944 0.139221365103221 4145 619834
SGTC_782 0083-0095 30.5 µM -1.08392130427037 0.12547554791867 no 2945 0.13919984637295 4163 3591729 An indicator and reagent.
SGTC_1772 st048439 82.2 µM -1.08451995323456 0.125344709753941 no 2946 0.139067162464225 4234 2927068 YDL195W SEC31
SGTC_2492 derrusnin 100 µM -1.08578995138252 0.125067459790725 no 2947 0.138785966568398 4170 1715307 Part of coumarin class of compounds.
SGTC_222 nsc-310342 10.666 µM -1.08604959545368 0.125010830350166 no 2948 0.138728525339086 4183 432556
SGTC_898 1000-0849 28.3 µM -1.086590415396 0.124892932808107 no 2949 0.13860893138471 4170 6751807
SGTC_1065 prochlorperazine maleate 2.48 µM -1.0872908310175 0.124740359246866 no 2950 0.138454149734543 4212 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1393 3470-5649 58.2 µM -1.08818636453207 0.124545472399519 no 2951 0.13825642150877 4156 4108395
SGTC_995 3931-2021 34.6 µM -1.09035159273665 0.124075153199305 no 2952 0.137779148300555 4190 730143
SGTC_3156 9099931 49.47 µM -1.09416690283385 0.123249439142673 no 2953 0.136940892189335 4213 18111053
SGTC_3066 9117245 49.47 µM -1.09433428490439 0.123213302492108 no 2954 0.136904196902129 4248 17176980
SGTC_2434 5670830 169.91 µM -1.09504275407636 0.123060431043186 no 2955 0.136748953140062 4226 1549830
SGTC_2996 9066192 71.4286 µM -1.09680914506323 0.122679863387179 no 2956 0.136362415827498 4222 6472854
SGTC_2023 5144124 124 µM -1.09703403190587 0.122631470988043 no 2957 0.136313257791351 4174 2830192
SGTC_2109 5483026 200 µM -1.09882566989181 0.122246414675747 no 2958 0.135922056565439 4202 759335
SGTC_3163 9099914 49.47 µM -1.10272060825375 0.121412250343587 no 2959 0.135074257224094 4215 16268368
SGTC_1068 loratadine 26.9 µM -1.10609130861791 0.120693597006133 no 2960 0.134343500112948 4221 3957 A H1 histamine antagonist.
SGTC_2188 6126565 140.678 µM -1.11233347951207 0.119370648111109 no 2961 0.132997397054446 4118 874518
SGTC_749 1000-0129 128 µM -1.11272778826605 0.119287424329873 no 2962 0.132912678596055 4256 708470
SGTC_2287 7945887 168.79 µM -1.11464545231409 0.118883261276884 no 2963 0.132501192330848 4224 1245853
SGTC_2411 st077133 39.94 µM -1.1182788232229 0.118120153489717 no 2964 0.131723964231678 4257 1403142 YNL221C POP1
SGTC_358 0075-0058 9.45 µM -1.11944149130776 0.11787669446505 no 2965 0.131475919234147 4024 1069125
SGTC_214 4373-3496 70 µM -1.12538751279951 0.116637167199105 no 2966 0.130212430121004 4299 3779166
SGTC_34 0469-0683 81.75 µM -1.12545545268664 0.116623057836155 no 2967 0.130198042070853 4181 3690923
SGTC_3051 9093778 49.47 µM -1.12627404606795 0.116453152234353 no 2968 0.130024769963106 4277 17217378
SGTC_1411 3909-8223 150 µM -1.12674121948712 0.116356265389423 no 2969 0.129925954679825 4247 X1411
SGTC_879 0831-1030 162 µM -1.13010250917666 0.115660855088716 no 2970 0.129216516288425 4229 1549252
SGTC_6 0844-0013 19.835 µM -1.13095861547023 0.115484209716229 no 2971 0.129036255190791 4357 1584900
SGTC_3264 9137442 49.47 µM -1.13115232840947 0.115444266412549 no 2972 0.128995491343389 4219 17015726
SGTC_905 2-aminofluorene 215 µM -1.13178984064245 0.11531288171502 no 2973 0.128861399960441 4243 1539 An established DNA mutagen. YPR165W RHO1
SGTC_441 propafenone 146 µM -1.13313846446572 0.11503529455858 no 2974 0.128578055333129 4206 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2460 5552655 174.22 µM -1.13513977102996 0.11462424209889 no 2975 0.128158380051306 4256 5401989
SGTC_1852 st056254 31.4 µM -1.13822138142186 0.113993349565891 no 2976 0.127514026344175 4171 442583
SGTC_409 arachidonic acid 100 µM -1.13871165762296 0.113893204754022 no 2977 0.127411719418561 4217 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_298 1391-0729 10 µM -1.14050864615944 0.113526684265278 no 2978 0.127037226323381 4159 3237558
SGTC_2713 st079149 53.4 µM -1.14139310550362 0.113346595805356 no 2979 0.12685318624082 4237 3103253
SGTC_215 1287-0124 461.5 µM -1.14256273087278 0.113108756532605 no 2980 0.126610093388045 4241 5560863
SGTC_737 1950-0117 57.9 µM -1.14483116342845 0.112648494187027 no 2981 0.126139551705446 4224 5393513
SGTC_736 0958-0254 92.6 µM -1.14632949421645 0.112345219036013 no 2982 0.125829421784165 4320 6812352
SGTC_931 2812-0076 566 µM -1.14641647594867 0.112327631113331 no 2983 0.125811434338014 4185 3450959
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.14833149918278 0.111940907049867 no 2984 0.125415870171435 4297 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2090 5301565 104.445 µM -1.14972141077298 0.111660822078934 no 2985 0.125129316453601 4244 2056344
SGTC_1672 st016598 6.51 µM -1.15140282627758 0.111322665891747 no 2986 0.124783275825455 4239 4665860 YNL267W PIK1
SGTC_1387 3342-1166 1.8 µM -1.15274483767406 0.111053295144079 no 2987 0.12450756592053 4211 3418228
SGTC_99 0109-0120 622.8 µM -1.15591937206659 0.110417956297531 no 2988 0.12385706900595 4199 759414
SGTC_2429 5902844 64.44 µM -1.16028989721268 0.109547526519278 no 2989 0.122965398195778 4253 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1840 st055363 71 µM -1.16266208059593 0.109077152817996 no 2990 0.122483316120113 4285 676033
SGTC_479 n-linoleoylglycine 10 µM -1.16556228497095 0.108504053632029 no 2991 0.121895731957159 4299 6433346 An anti-infammatory.
SGTC_260 nsc-65238 3.989 µM -1.16745970141955 0.108130285957857 no 2992 0.121512386696017 4253 3246252
SGTC_2773 thioridazine 9.09 µM -1.16864818109102 0.107896642710898 no 2993 0.12127270382814 4250 5452 An antipsychotic.
SGTC_1972 st070201 17.4 µM -1.16936629734733 0.107755644552792 no 2994 0.121128041249787 4269 2829099
SGTC_1044 1222-0021 1.78 µM -1.16970435913909 0.1076893139576 no 2995 0.1210599816546 4203 4306703
SGTC_110 0850-0284 111.64 µM -1.16983120870326 0.107664432586875 no 2996 0.121034450869493 4068 3906265
SGTC_828 2074-0507 139 µM -1.17136629170011 0.107363656428168 no 2997 0.120725787731372 4334 X828
SGTC_2194 5927483 104.545 µM -1.1733176152183 0.106982199235867 no 2998 0.12033423043842 4300 760979
SGTC_1700 st030840 7.9285 µM -1.17507333861871 0.106639815608833 no 2999 0.119982688066015 4308 5499307
SGTC_254 nsc-64875 3.808 µM -1.17523970241658 0.106607414071945 no 3000 0.119949415208092 4261 56993
SGTC_2119 5528445 120.635 µM -1.17897060663567 0.105882637212334 no 3001 0.119204940172889 4277 791935
SGTC_3082 9117008 49.47 µM -1.17904970240389 0.105867310471759 no 3002 0.11918919256665 4309 41448529
SGTC_2068 5226020 147 µM -1.18131133702151 0.105429741647928 no 3003 0.118739532615085 4281 1810509
SGTC_87 0100-0052 35.5 µM -1.18199892283225 0.105296970939323 no 3004 0.118603064132802 4306 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2417 cerulenin 830 nM -1.18276042223839 0.105150068962904 no 3005 0.118452055044282 4284 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_178 4092-0806 87.505 µM -1.18419119401652 0.104874457898104 no 3006 0.118168693594785 4165 2169044
SGTC_1037 k284-1091 78.7 µM -1.1842642865318 0.104860392066246 no 3007 0.118154230651137 4256 3334711
SGTC_1647 st011722 22.4 µM -1.18809668241486 0.104124802872231 no 3008 0.117397660629805 4250 2854783
SGTC_3080 9117754 49.47 µM -1.18970086178628 0.103818010290177 no 3009 0.117081993277762 4280 9550191
SGTC_3092 9117248 49.47 µM -1.19082833416182 0.103602778636324 no 3010 0.116860491602497 4413 17141857
SGTC_343 4130-2827 29.8 µM -1.19367257773353 0.103061258752084 no 3011 0.11630303566445 4272 1118244
SGTC_3062 9077494 49.47 µM -1.19562680245387 0.102690384336959 no 3012 0.115921113654612 4236 16459633
SGTC_2054 5233173 129 µM -1.1967640896664 0.102474996028864 no 3013 0.115699259371307 4310 6889
SGTC_361 000s-0510 1.45 µM -1.19969282080266 0.101921842607088 no 3014 0.115129331132554 4207 660
SGTC_1758 st042942 75.2445 µM -1.20072415746538 0.101727570938952 no 3015 0.114929110034078 4257 669317
SGTC_294 k038-0071 157 µM -1.20090328767857 0.101693855889172 no 3016 0.114894359405563 4296 24152826
SGTC_462 ag-879 158 µM -1.20183891590697 0.101517888541954 no 3017 0.114712972304665 4320 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_896 0964-0007 44.5 µM -1.20321583577269 0.101259329181319 no 3018 0.114446404201 4252 6756758
SGTC_1653 st012112 65 µM -1.20463557661987 0.100993231640472 no 3019 0.114172008128288 4273 720429
SGTC_2321 7390090 138.78 µM -1.20569335944107 0.100795306382063 no 3020 0.113967873216252 4314 649046
SGTC_1261 0712-0010 12.7 µM -1.21119104345527 0.0997711707653585 no 3021 0.11291109730003 4300 2840123
SGTC_332 4112-0506 40.9 µM -1.21183917697539 0.0996509359927567 no 3022 0.112786974205809 4267 2790355
SGTC_3180 9109287 49.47 µM -1.21186983518712 0.0996452512340416 no 3023 0.112781105310985 4335 18891271
SGTC_2867 9039098 71.43 µM -1.21479596079757 0.0991037682784321 no 3024 0.112221960896404 4269 6463460
SGTC_2796 7949634 45.45 µM -1.2173914508653 0.0986252736082964 no 3025 0.111727657110669 4274 2971588
SGTC_3008 9078912 71.4286 µM -1.2182002494029 0.0984765127443589 no 3026 0.111573942458871 4309 16648731
SGTC_1385 3091-4834 14.1 µM -1.21879821097033 0.0983666364237449 no 3027 0.111460395354148 4269 4072814
SGTC_3102 9121669 49.47 µM -1.22076449876149 0.0980059611785062 no 3028 0.111087599507177 4347 41905072
SGTC_2985 9022375 71.43 µM -1.22165238275388 0.0978434150042968 no 3029 0.110919555221429 4359 4939335
SGTC_81 0411-0046 9.971 µM -1.22403980355685 0.097407326703719 no 3030 0.110468606244035 4268 12925265
SGTC_1702 st027038 51 µM -1.22676610799175 0.0969110832935864 no 3031 0.109955256330968 4333 5521182
SGTC_3057 9095946 49.47 µM -1.22689688945426 0.0968873251215227 no 3032 0.109930673914514 4358 24540043
SGTC_1930 st074634 34.3 µM -1.22981134614493 0.0963589847546186 no 3033 0.109383879207455 4202 684253 YOR116C RPO31
SGTC_3147 9097027 49.47 µM -1.23008128164123 0.0963101574810253 no 3034 0.109333334384359 4297 25236841
SGTC_1488 4013-0813 75.9 µM -1.23081955908088 0.0961767070728654 no 3035 0.109195179273121 4250 2910057
SGTC_622 1348-1566 26.3 µM -1.23221293976842 0.0959252112237179 no 3036 0.108934775449248 4302 7340407
SGTC_3309 9129340 25.759 µM -1.23565497112984 0.0953060214349261 no 3037 0.108293420972645 4332 17158987
SGTC_1713 st033146 12.748 µM -1.23631446507911 0.0951877212090196 no 3038 0.10817084816984 4308 674619
SGTC_678 1218-2179 85.9 µM -1.23818397973787 0.0948529548991877 no 3039 0.107823925167411 4337 6820081 YOR116C RPO31
SGTC_2511 berberine 10.47 µM -1.24291157600179 0.0940102756444677 no 3040 0.106950209729276 4297 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_155 k072-0202 43.6 µM -1.24320878262235 0.0939574846475827 no 3041 0.106895453575883 4316 5857737
SGTC_427 1354-0053 47.3 µM -1.24428248656015 0.0937669514506777 no 3042 0.106697807197691 4374 6813657
SGTC_151 3013-0144 2.285 µM -1.24581848682986 0.0934948779614871 no 3043 0.106415520488708 4146 906558 YHR107C CDC12
SGTC_460 trequinsin 123 µM -1.24930863687394 0.0928788320929342 no 3044 0.105776105079628 4409 5537 A vasodilator.
SGTC_3229 9132204 49.47 µM -1.24942554354322 0.0928582489866376 no 3045 0.105754735287925 4392 17682924
SGTC_711 k292-0785 179 µM -1.24957008581343 0.0928328048970518 no 3046 0.10572831820015 4244 4146315
SGTC_596 1155-0152 116 µM -1.25079516424063 0.0926173586611 no 3047 0.105504609816013 4345 280313
SGTC_2680 butyl paraben 22.24 µM -1.25097610304585 0.0925855695528261 no 3048 0.105471598087271 4428 7184 An antifungal and steroid mimetic.
SGTC_1187 1391-0724 117 µM -1.25110464521521 0.0925629909049444 no 3049 0.105448150502962 4366 6997986
SGTC_1510 1123-0200 71.5 µM -1.25155956826042 0.0924831156255769 no 3050 0.105365197540963 4345 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_107 0358-0022 2.6945 µM -1.25160871093253 0.0924744902198983 no 3051 0.105356239444279 4360 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_527 4476-4215 268 µM -1.25494715167673 0.0918899277187549 no 3052 0.104748972737811 4334 4418754
SGTC_2446 5162541 200 µM -1.25645116193231 0.0916274708556716 no 3053 0.104476221092142 4296 1549321
SGTC_2655 perillic acid 100 µM -1.25685883866802 0.0915564251269112 no 3054 0.104402377803852 4362 5702197 An apoptosis inducer.
SGTC_1390 3413-2614 145 µM -1.25820058853223 0.0913228869745881 no 3055 0.104159611096544 4346 3421432
SGTC_2706 st078239 82.5 µM -1.25950788390295 0.0910957708447791 no 3056 0.103923472195916 4314 15434492
SGTC_2618 avocadyne 43.43 µM -1.26823388589385 0.0895905249161138 no 3057 0.102357219641677 4261 3015189
SGTC_235 0330-0087 5 mM -1.26834846218499 0.0895708841349747 no 3058 0.1023367688598 4393 46494818 YHR062C RPP1
SGTC_2122 5258151 111.688 µM -1.26933975219013 0.0894010898931877 no 3059 0.102159957051322 4343 2173356
SGTC_2152 5568786 200 µM -1.27021023168286 0.0892521863500202 no 3060 0.102004877003381 4365 5399883
SGTC_2860 9025725 38.96 µM -1.27688895501044 0.0881158633315403 no 3061 0.100820727036118 4383 40546248
SGTC_2448 5185112 27.17 µM -1.27698673841952 0.088099306874827 no 3062 0.100803464626962 4348 5718189
SGTC_2821 7996764 71.43 µM -1.28249129495844 0.0871710241547776 no 3063 0.0998351783479131 4381 2987135
SGTC_1429 4049-0205 9.46 µM -1.28308039103588 0.0870721138854559 no 3064 0.0997319564513451 4385 22774478
SGTC_3084 9116877 49.47 µM -1.28680683609327 0.0864483785411376 no 3065 0.0990808118177561 4305 27241325
SGTC_321 4534-3890 65.3 µM -1.28706328217373 0.0864055775684683 no 3066 0.0990361160428851 4338 699746
SGTC_186 3455-3465 67.277 µM -1.28706478376992 0.0864053269980199 no 3067 0.0990358543743669 4364 755278
SGTC_2373 9071805 200 µM -1.28715313963199 0.0863905840653152 no 3068 0.0990204583506723 4365 10149009
SGTC_2270 7924575 90.91 µM -1.28769234930157 0.0863006530751073 no 3069 0.0989265389189011 4322 1262135
SGTC_2477 5967686 25.23 µM -1.29042613015513 0.0858457820430177 no 3070 0.0984513722287225 4338 776118
SGTC_1783 st039459 87.517 µM -1.29245097940181 0.0855100279101499 no 3071 0.0981005058929467 4440 729761
SGTC_2971 9092186 9.93 µM -1.2971310617777 0.0847377561662167 no 3072 0.097293047780099 4325 25236400
SGTC_1669 st015249 58.4 µM -1.30652639099483 0.083203218005094 no 3073 0.0956868051527575 4477 722793
SGTC_2242 6630449 61.2675 µM -1.30696031800486 0.0831328528958207 no 3074 0.095613094397951 4415 691249 YDR170C SEC7
SGTC_1174 0739-0097 51.1 µM -1.31003472585789 0.0826355915976881 no 3075 0.0950920441624578 4417 728447
SGTC_835 0312-0010 67.2 µM -1.31039422480337 0.0825775919698421 no 3076 0.0950312531638476 4382 1626196
SGTC_2724 maprotiline 69.64 µM -1.31300380612786 0.0821574943202708 no 3077 0.0945908328220996 4314 4011 A tricyclic antidepressant.
SGTC_3347 9188721 44.724 µM -1.31378066759949 0.0820327444872306 no 3078 0.0944600126105828 4381 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_804 1595-0054 20.9 µM -1.31852256362387 0.081274374623336 no 3079 0.0936643884175497 4352 761523 Stimulates phospholipase C.
SGTC_2568 diosmetin 100 µM -1.31925844207927 0.0811571614573399 no 3080 0.0935413630754854 4398 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.32284198512259 0.0805881852524128 no 3081 0.0929439658275793 4381 140250 A respiratory chain inhibitor.
SGTC_1954 st077032 68.9 µM -1.32458642840237 0.0803123043736387 no 3082 0.0926541798454312 4332 698907
SGTC_1450 4112-4260 37.6 µM -1.32828213615487 0.079730192667477 no 3083 0.0920424594519477 4384 1633175
SGTC_2623 humulene 100 µM -1.33208387890796 0.07913471545829 no 3084 0.0914163135756484 4374 6187145 An anti-inflammatory.
SGTC_223 busulfan 5 mM -1.33230038197766 0.0791009056280166 no 3085 0.0913807508428448 4376 2478 A DNA alkylator.
SGTC_3012 9080433 71.4286 µM -1.33253786802832 0.0790638316083188 no 3086 0.0913417532472039 4389 17688859
SGTC_2813 7971799 71.43 µM -1.33515605426893 0.0786559775955669 no 3087 0.0909126382619549 4405 2234054
SGTC_48 0382-0018 55 µM -1.3367979510328 0.0784010220453207 no 3088 0.090644299104048 4428 762596
SGTC_2379 9035213 200 µM -1.33775675184521 0.0782524284550376 no 3089 0.0904878720974702 4389 646551
SGTC_1618 st003135 44.5 µM -1.33951836999258 0.0779799722333171 no 3090 0.0902009891233279 4368 1270615
SGTC_2106 5357045 167.29 µM -1.34416284891144 0.07726509645899 no 3091 0.0894478661395028 4416 668842
SGTC_1711 st032263 62.8 µM -1.34745544128062 0.0767613259478156 no 3092 0.088916797544677 4382 3958979
SGTC_1897 st060201 15 µM -1.35049367652973 0.0762986915382129 no 3093 0.0884288403347313 4417 611878
SGTC_1332 1480-0653 17.5 µM -1.35111116454241 0.0762049261414225 no 3094 0.0883299128063133 4392 5749438
SGTC_954 1189-0853 2.85 µM -1.35274962434692 0.075956551550508 no 3095 0.0880678155611551 4322 2828194
SGTC_1427 4048-4900 550 nM -1.35653604258494 0.0753849260416843 no 3096 0.087464337819474 4397 24132586
SGTC_2815 7968870 71.43 µM -1.35860058760074 0.0750746315607367 no 3097 0.0871365944469783 4346 2977326 YHR190W ERG9
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.36223834784382 0.0745302593361942 no 3098 0.0865613386390533 4365 6857784
SGTC_1860 st056228 74.6 µM -1.3687630757556 0.0735614230961505 no 3099 0.0855366732019663 4394 688679
SGTC_2070 5230947 200 µM -1.37342873758473 0.0728745597815848 no 3100 0.0848095504964621 4514 2835538
SGTC_2182 6325192 200 µM -1.37641355536787 0.0724377267815426 no 3101 0.084346816809894 4430 736248
SGTC_2317 5986382 200 µM -1.37887677785847 0.0720787433344754 no 3102 0.0839663745877969 4440 877883
SGTC_168 3970-0862 530.542 µM -1.37977075769621 0.0719487949486725 no 3103 0.0838286194575204 4363 3135186
SGTC_201 4262-0159 12.803 µM -1.37985229354562 0.0719369518903483 no 3104 0.0838160638882013 4468 1341029
SGTC_3296 9122258 64.045 µM -1.38487230750673 0.0712106716675193 no 3105 0.0830457580317822 4394 4730474
SGTC_3120 9124077 49.47 µM -1.387133916265 0.0708853142549697 no 3106 0.0827004658269881 4542 18774327 YGL155W CDC43
SGTC_752 1896-0090 130 µM -1.38779774870995 0.0707900317380017 no 3107 0.0825993202797468 4415 772567
SGTC_146 3448-8650 53.125 µM -1.38810260388493 0.0707463076454853 no 3108 0.0825529019020368 4406 2891488 YIL048W NEO1
SGTC_2178 5812956 200 µM -1.3912460843036 0.0702966609110774 no 3109 0.0820754085021822 4393 5403383
SGTC_2072 5231554 129 µM -1.39160986158304 0.07024476802553 no 3110 0.0820202854840582 4487 789545
SGTC_2282 7944268 200 µM -1.39290474547086 0.0700602916897528 no 3111 0.0818242986192033 4432 2970414
SGTC_3169 9102970 49.47 µM -1.39506989621748 0.0697526652384867 no 3112 0.0814973815287843 4508 17027839
SGTC_3290 9121031 71.43 µM -1.40021682921093 0.0690255588134277 no 3113 0.0807241988728937 4449 17014854
SGTC_1844 rapamycin 4 nM -1.40061760312294 0.0689691876058868 no 3114 0.0806642270555219 4279 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1195 1502-0147 41.1 µM -1.40383388345487 0.0685180831200281 no 3115 0.0801841607839827 4433 817940
SGTC_3182 9108849 49.47 µM -1.41632412257627 0.0667878013863689 no 3116 0.0783403141291916 4470 17133045
SGTC_29 0299-0004 12.984 µM -1.41798628054638 0.0665601132553753 no 3117 0.078097385141402 4351 16871 A napthoquinone isolated from Swertia calycina.
SGTC_132 0417-1715 25.805 µM -1.41892408447396 0.0664319150327745 no 3118 0.0779605749027673 4431 6769098
SGTC_3112 9123419 49.47 µM -1.42461127064452 0.0656585650972395 no 3119 0.0771348001319427 4504 17015854
SGTC_2409 alverine citrate 63.97 µM -1.42605214680937 0.065463745652627 no 3120 0.0769266451367417 4486 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_901 1112-0062 60.1 µM -1.4290184160177 0.0650640910851532 no 3121 0.0764994701899388 4443 1908457
SGTC_2635 hydroquinidine 100 µM -1.43047344130062 0.0648687445621721 no 3122 0.076290591551772 4377 442912 An experimental heart treatment.
SGTC_2885 9057732 51.95 µM -1.43120839272942 0.0647702458375984 no 3123 0.076185249463367 4479 6471414
SGTC_1007 4101-0031 70 µM -1.43210909341848 0.0646496917007947 no 3124 0.0760563012176617 4437 1146276
SGTC_2397 5161689 200 µM -1.43263627089001 0.064579212611598 no 3125 0.0759809053114956 4485 2259942
SGTC_230 MPP+ 141.667 µM -1.43319204197015 0.0645049754441527 no 3126 0.0759014816384025 4424 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_181 1447-1644 8.07 µM -1.4345827441599 0.0643195027956545 no 3127 0.0757030173662136 4412 534600
SGTC_2769 toremifene 3.73 µM -1.44039183228537 0.0635492448338828 no 3128 0.0748782865888107 4466 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1440 4100-1550 40 µM -1.44117648476409 0.0634457561688391 no 3129 0.0747674149731608 4487 742806
SGTC_603 3794-0023 45.9 µM -1.44620577343007 0.0627855496961294 no 3130 0.0740597474338477 4497 3802260
SGTC_106 0092-0003 11.579 µM -1.4470600716439 0.0626739377987867 no 3131 0.073940049850502 4363 1072148
SGTC_2437 5741531 144.16 µM -1.44866711342072 0.0624644009804806 no 3132 0.0737152843911486 4480 2262990
SGTC_2765 myclobutanil 7.74 µM -1.44902493793454 0.0624178198674366 no 3133 0.0736653091977159 4472 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_623 k072-0108 16.9 µM -1.45187967613453 0.0620471633379513 no 3134 0.0732675322906057 4432 5382803
SGTC_2757 clomiphene 4.22 µM -1.45198464449458 0.062033567151143 no 3135 0.0732529374666815 4472 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_392 N-ethylmaleimide 8.33 µM -1.45251438153351 0.0619649876198162 no 3136 0.0731793166452063 4420 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1255 0566-0045 221 µM -1.4533125555293 0.0618617681052409 no 3137 0.0730684964154942 4482 2788469
SGTC_1706 st031321 9.9705 µM -1.45428527327956 0.0617361581566661 no 3138 0.0729336158310808 4488 6103185
SGTC_1405 3909-7894 12 µM -1.4579795476421 0.0612609188567544 no 3139 0.0724230902552332 4458 7104060
SGTC_1512 0259-0544 12.2 µM -1.46566403124893 0.0602815314176448 no 3140 0.0713699188774044 4434 18476
SGTC_3005 9076496 71.4286 µM -1.46953333235914 0.0597930499217033 no 3141 0.0708440938976806 4450 21368410
SGTC_3317 9138495 8.753 µM -1.4726332591899 0.0594039402516285 no 3142 0.0704249758199904 4386 17020139
SGTC_1763 st044482 94.5 µM -1.47594114520411 0.0589909193251813 no 3143 0.0699798463327137 4460 88505
SGTC_1129 3453-1384 223 µM -1.47621190480317 0.0589572124197265 no 3144 0.0699435073214225 4482 1084452
SGTC_789 1309-1135 70.6 µM -1.47651235056401 0.058919827567928 no 3145 0.069903201087435 4462 3092424
SGTC_2712 st079126 47.7 µM -1.47890161384394 0.0586231902075525 no 3146 0.0695833059866419 4486 3152970
SGTC_924 2046-0044 21.3 µM -1.48098854952539 0.0583650485333236 no 3147 0.0693048123951424 4460 3623589
SGTC_2333 9017922 200 µM -1.48230469715422 0.0582027084193633 no 3148 0.0691296195253054 4488 3163164
SGTC_2349 9023730 187.07 µM -1.48295439670649 0.0581227021716705 no 3149 0.0690432636942983 4517 4126287
SGTC_2852 9023854 51.95 µM -1.48377142452863 0.0580222132360054 no 3150 0.0689347852062819 4491 19798528
SGTC_2465 5809242 33.21 µM -1.48401598014203 0.0579921611034814 no 3151 0.0689023406085163 4563 2731748
SGTC_51 1013-0126 23.419 µM -1.48438420610251 0.0579469348611824 no 3152 0.0688535111744477 4472 1627850
SGTC_2131 toluylene red 5.2905 µM -1.48868858115945 0.0574203167305074 no 3153 0.0682846966488291 4438 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1587 estradiol valerate 56.1 µM -1.48980612875369 0.0572842080718713 no 3154 0.0681376095965986 4535 13791 A steroid.
SGTC_1435 4092-0789 56.7 µM -1.49539256296829 0.0566076264909211 no 3155 0.0674060101676779 4489 2248285
SGTC_2457 5731572 11.68 µM -1.49542453254055 0.0566037728050657 no 3156 0.0674018409738595 4542 2865357
SGTC_1380 2291-0730 164 µM -1.49548608671445 0.056596353505339 no 3157 0.0673938141746943 4493 2999191
SGTC_1358 1509-0022 2.48 µM -1.49674230692519 0.0564451050305518 no 3158 0.0672301616608488 4529 3258434
SGTC_776 4476-4378 112 µM -1.50008674594872 0.056043988506584 no 3159 0.0667959668730803 4545 2892008
SGTC_1906 st060206 94.7 µM -1.50147655868707 0.0558779634657145 no 3160 0.0666161726341358 4510 5133468
SGTC_870 0573-2213 57.6 µM -1.50337826164485 0.0556514177440403 no 3161 0.0663707645063874 4482 3916321
SGTC_2006 4011487 200 µM -1.50476749401422 0.0554863802047174 no 3162 0.0661919318337871 4461 45595294
SGTC_2044 5102272 200 µM -1.50552035073787 0.0553971041682651 no 3163 0.0660951743850177 4494 592666
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.50680995208963 0.0552444429065845 no 3164 0.0659296889404066 4578 4620898
SGTC_783 0848-0141 92.7 µM -1.50722426665073 0.055195467496413 no 3165 0.0658765910771924 4434 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1409 3909-8004 61.9 µM -1.51378801066013 0.0544241452860657 no 3166 0.0650398072030425 4541 2119279
SGTC_2249 haloperidol 116.36 µM -1.51488779162986 0.0542957452245548 no 3167 0.0649004112853458 4445 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1588 farnesol 29.9 µM -1.51707658322981 0.0540409157862884 no 3168 0.0646236748325555 4514 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_930 2810-3379 265 µM -1.51709045522369 0.0540393037675799 no 3169 0.0646219238759976 4497 1015764
SGTC_1023 4482-3888 16 µM -1.51922677088423 0.0537915035185768 no 3170 0.0643527124885251 4506 3303168
SGTC_1649 st011737 51.3 µM -1.52081820682497 0.0536074916830846 no 3171 0.0641527320775123 4526 1761035
SGTC_2553 4-methylesculetin 85.09 µM -1.5273058027499 0.0528625096645461 no 3172 0.0633424936147689 4515 5319502
SGTC_1648 st011736 69.8 µM -1.53192434943626 0.0523371759431403 no 3173 0.0627705520186051 4491 2855514
SGTC_162 k030-0015 37.8 µM -1.53375772530309 0.0521297925862946 no 3174 0.062544633337758 4564 1809920 YMR134W ERG29
SGTC_3079 9117512 49.47 µM -1.53797651229734 0.0516550611000833 no 3175 0.0620271788914463 4599 7185044
SGTC_1243 0416-0003 5.65 µM -1.53945622590142 0.0514893684373658 no 3176 0.061846478313389 4501 2141977
SGTC_868 0527-0199 213 µM -1.5402822347305 0.0513970591190198 no 3177 0.0617457861127822 4505 2849450
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.54067710608768 0.0513529774179352 no 3178 0.061697695706575 4579 279621
SGTC_1214 0358-0031 63.7 µM -1.54495072320542 0.0508778113103952 no 3179 0.0611790915036865 4526 4301366
SGTC_2018 5133068 143 µM -1.54925971263633 0.0504022628926748 no 3180 0.0606596501303644 4485 785362
SGTC_1501 4491-0275 38.4 µM -1.55454198231453 0.0498241410477636 no 3181 0.0600275953099001 4530 5104718
SGTC_1363 1636-0063 10.4 µM -1.56006595087228 0.0492252370920416 no 3182 0.0593721484189731 4532 6072185
SGTC_982 1491-0518 27.5 µM -1.56337713667109 0.0488690059234094 no 3183 0.0589819572930246 4477 3091256
SGTC_3320 9137005 35.139 µM -1.57221234955952 0.0479285526901765 no 3184 0.0579506561691036 4567 4908713
SGTC_1879 gemcitabine 100 µM -1.57430074639182 0.0477083864033891 no 3185 0.0577089686528264 4494 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2473 5854593 8.94 µM -1.5793993819714 0.0471742716102743 no 3186 0.0571222395236249 4488 2872951
SGTC_1151 3909-8316 15.3 µM -1.57982876409933 0.0471295107873362 no 3187 0.0570730432229098 4566 800431
SGTC_2047 4141938 200 µM -1.58498178398259 0.0465949875400407 no 3188 0.0564852365465902 4560 3807862
SGTC_936 3005-4620 401 µM -1.58639836370134 0.0464489012402628 no 3189 0.0563244856911523 4544 777207
SGTC_1152 3909-8331 15.9 µM -1.58809620366072 0.0462742943145967 no 3190 0.05613229332269 4523 16001939
SGTC_2276 7947513 42.08 µM -1.59573942833048 0.0454947769029464 no 3191 0.0552734908844938 4473 2105100
SGTC_2395 5646831 180.19 µM -1.60307328018972 0.0447567729500849 no 3192 0.0544592381806551 4520 6808628
SGTC_880 0833-0487 87.2 µM -1.60318310838393 0.0447457946681086 no 3193 0.0544471168260817 4533 76075
SGTC_794 k038-0031 316 µM -1.61088608491303 0.0439812089916864 no 3194 0.0536022767272168 4527 6624242
SGTC_756 0508-1999 28.3 µM -1.61474103492483 0.0436025474507675 no 3195 0.0531833935836021 4574 6753853
SGTC_1898 st060199 18.6 µM -1.61918238437717 0.0431695518824251 no 3196 0.0527040135135145 4549 688866
SGTC_1102 cgs 12066b 26.1 µM -1.62165118493629 0.0429303697048252 no 3197 0.0524390282249087 4577 6438352 A 5-HT1B full agonist.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.6264324714079 0.0424701949777819 no 3198 0.051928843930341 4585 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_419 nsc-638432 893 µM -1.62663332362574 0.0424509516179638 no 3199 0.0519074987442333 4542 368090
SGTC_559 1550-0661 158 µM -1.62681489058776 0.0424335620200313 no 3200 0.051888209062434 4598 5830875
SGTC_515 4092-1064 102 µM -1.62777187425348 0.0423420019840569 no 3201 0.051786633195521 4527 717353
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.62971296300128 0.0421567779098761 no 3202 0.0515810881729247 4568 688751
SGTC_1889 st059080 5.18 µM -1.63430976649258 0.0417207525929656 no 3203 0.0510969120011422 4533 176925 Isolated from Daphnopsis sellowiana.
SGTC_981 1488-1094 54.9 µM -1.63493749572893 0.0416614944195532 no 3204 0.051031075579359 4532 3449522
SGTC_571 k831-0106 44.2 µM -1.63948758968812 0.0412339971188962 no 3205 0.0505558765984331 4460 4783639
SGTC_2412 st077135 33.4 µM -1.65106699811283 0.0401620967245733 no 3206 0.0493624475688043 4572 13258915
SGTC_832 4083-0019 164 µM -1.65231568765285 0.0400478707449511 no 3207 0.0492351064646615 4616 1990758
SGTC_944 3370-0224 231 µM -1.65513359801494 0.03979106756177 no 3208 0.0489487004812942 4532 4580514
SGTC_3000 9075062 71.4286 µM -1.65632140182893 0.039683221880195 no 3209 0.0488283743113052 4554 17057871
SGTC_1408 3909-7976 48.8 µM -1.65782463807697 0.0395470776237484 no 3210 0.0486764334011663 4612 24152374
SGTC_1753 st043925 64 µM -1.65816638233369 0.0395161797816431 no 3211 0.048641944085359 4585 670181
SGTC_1730 st033808 45.1 µM -1.65873808824908 0.0394645345080924 no 3212 0.0485842903921364 4502 1045166
SGTC_831 k061-1017 217 µM -1.66171129270183 0.0391968335583962 no 3213 0.0482853378936722 4608 1240153
SGTC_1139 k015-0024 46.9 µM -1.6672955883307 0.0386980310813985 no 3214 0.0477278217273457 4602 2766652
SGTC_1963 st076565 50.3 µM -1.66980905908772 0.0384752157552865 no 3215 0.0474785737343502 4598 4914280
SGTC_2824 7998404 51.95 µM -1.67369811022866 0.0381325189885609 no 3216 0.0470949726928177 4556 837851
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.67541583583831 0.0379819505114095 no 3217 0.0469263358514021 4576 6708561
SGTC_1018 4259-0013 28.1 µM -1.67613038288538 0.0379194593923155 no 3218 0.0468563283366715 4613 6801262
SGTC_2497 7-hydroxyflavone 100 µM -1.67631021298179 0.0379037454691772 no 3219 0.0468387227421532 4579 5281894
SGTC_539 4859-0462 2.54 µM -1.67881291600779 0.0376856051802583 no 3220 0.0465942552909587 4593 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1819 st053448 58.6 µM -1.68248299365455 0.0373675687257656 no 3221 0.0462376099608983 4526 2857616
SGTC_2836 9010338 19.48 µM -1.68299732941659 0.0373231737991467 no 3222 0.0461878042055249 4540 2994051
SGTC_829 1635-0120 117 µM -1.70454171027374 0.0355019290296197 no 3223 0.0441399652902361 4571 285054
SGTC_163 TUB2.036 7.546 µM -1.7056895971049 0.0354069742441298 no 3224 0.044032943777466 4539 15992207 YJR013W GPI14
SGTC_3225 9130819 49.47 µM -1.71923432952586 0.0343021841095999 no 3225 0.0427858561040034 4564 4547121
SGTC_356 1634-0012 32.5 µM -1.71928336731107 0.0342982363669487 no 3226 0.0427813935238854 4598 735457
SGTC_1723 st034307 2.5525 µM -1.72211673314304 0.0340707721201395 no 3227 0.0425241872422786 4585 867466
SGTC_1464 k208-0027 110 µM -1.72562599299255 0.0337907677719526 no 3228 0.0422073599945552 4585 X1464
SGTC_524 r073-0010 27.8 µM -1.72944937641511 0.0334878573375742 no 3229 0.0418643496959732 4551 2772106
SGTC_2162 5663267 200 µM -1.73691479209746 0.0329028474241597 no 3230 0.0412011060291634 4613 6456493
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.75787396004011 0.0313053130370408 no 3231 0.0393844787139829 4673 16725076
SGTC_840 0245-0196 390 µM -1.75998801287282 0.0311478004757674 no 3232 0.0392049195232274 4678 3827528
SGTC_2086 5274770 176.623 µM -1.7657798981453 0.0307196179448842 no 3233 0.0387163911175599 4641 689278
SGTC_1552 6-methylflavone 10.6 µM -1.77050742371666 0.0303737443200387 no 3234 0.0383213244008772 4576 689013
SGTC_3110 9122132 49.47 µM -1.7750738405105 0.0300427274921273 no 3235 0.0379428478489928 4625 918317
SGTC_1928 4'-methoxychalcone 40.3 µM -1.77600214137159 0.0299758026829662 no 3236 0.0378662820989446 4613 641818
SGTC_7 0192-1582 4.227 µM -1.78763975171209 0.0291472431513813 no 3237 0.0369170738642238 4662 252616
SGTC_143 4032-1194 15.74 µM -1.79208726395432 0.0288356610967717 no 3238 0.0365594943457216 4637 1806963
SGTC_1141 3253-0389 52.6 µM -1.79212519938939 0.0288330153877488 no 3239 0.0365564565725685 4621 5402031
SGTC_585 0kpi-0023 191 µM -1.7923792147121 0.0288153049437396 no 3240 0.0365361209922524 4566 64601
SGTC_1123 mangostin 811.285 nM -1.79324654664365 0.0287549010156975 no 3241 0.0364667551695576 4615 5281650 An antioxidant.
SGTC_1583 clindamycin 39.6 µM -1.79620027066543 0.0285499829404739 no 3242 0.036231335852773 4627 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2170 morpholine 200 µM -1.79973311667887 0.028306484398473 no 3243 0.0359513946549613 4657 121171 Reacts with secondary amines.
SGTC_1109 tnp00067 928.257 nM -1.81076305878626 0.0275573519756424 no 3244 0.0350887684593567 4621 676295
SGTC_1080 nisoldipine 24.4 µM -1.81173707808749 0.0274920001133015 no 3245 0.035013415795946 4651 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_188 3229-0966 278.469 µM -1.81260446032334 0.0274339118863908 no 3246 0.0349464246914779 4671 5722370
SGTC_1498 4478-3555 97.6 µM -1.81353012336387 0.0273720335433209 no 3247 0.0348750484310267 4644 3437919
SGTC_1249 0481-0015 10.2 µM -1.82265556062633 0.0267682268561652 no 3248 0.034177787452745 4582 4227577
SGTC_1160 4092-0570 10.5 µM -1.82445161015928 0.0266507064914136 no 3249 0.034041912802952 4638 4994975
SGTC_1540 guanosine 70.6 µM -1.82603387903821 0.0265475317407912 no 3250 0.0339225794016937 4592 6802 Guanosine is a purine nucleoside
SGTC_2016 5121758 140 µM -1.82856749660926 0.0263830176656596 no 3251 0.0337322128142282 4553 2795203
SGTC_2244 6635614 200 µM -1.83350680615374 0.026064745323446 no 3252 0.0333636186674138 4599 836499
SGTC_3052 9092717 49.47 µM -1.84258168743324 0.0254883598050161 no 3253 0.0326950548348069 4635 25237534
SGTC_3318 9139014 38.6185 µM -1.8435463394515 0.0254277230225515 no 3254 0.0326246412286074 4626 16643984
SGTC_1550 gossypolone 36.6 µM -1.84489104969338 0.0253433979137033 no 3255 0.032526694456801 4662 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1459 k035-0031 35.7 µM -1.8452252271549 0.0253224784415207 no 3256 0.0325023911144867 4413 3877128 YMR208W ERG12
SGTC_3239 9133757 49.47 µM -1.84657234712548 0.025238295523008 no 3257 0.0324045725167271 4704 17036923
SGTC_2081 5214970 32.255 µM -1.85765042445668 0.0245548692380045 no 3258 0.0316093364414824 4601 2063512
SGTC_704 1310-0270 142 µM -1.85765403945192 0.0245546487830459 no 3259 0.0316090795968451 4618 5718033
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.85823075220497 0.0245195001012723 no 3260 0.0315681263603741 4636 688667
SGTC_3210 9128157 49.47 µM -1.87022886467371 0.0237977796094953 no 3261 0.0307260214973834 4586 17590849
SGTC_313 3474-0040 5.03 µM -1.87037184224002 0.0237892879593442 no 3262 0.0307160996661753 4659 1043375 YIL048W NEO1
SGTC_3074 9116018 49.47 µM -1.87069794931325 0.0237699295061873 no 3263 0.0306934796122957 4654 17027303
SGTC_1854 st056233 32.9 µM -1.88024657377942 0.0232089454764916 no 3264 0.0300372404385847 4602 5393174
SGTC_3245 9134821 49.47 µM -1.88206955997484 0.0231031215634727 no 3265 0.0299132858615516 4675 17014901
SGTC_1714 st033236 13.627 µM -1.89653556183689 0.0222776925338492 no 3266 0.0289446311017573 4630 2916566
SGTC_2059 5238311 157 µM -1.8985790405615 0.0221631220378576 no 3267 0.0288099231714763 4615 703021
SGTC_319 1348-1596 45.5 µM -1.91832628545129 0.0210813638831512 no 3268 0.0275348257370588 4715 5380505
SGTC_2580 diallyl disulphide 81.36 µM -1.92576149690105 0.0206858042606466 no 3269 0.027067080580067 4627 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_841 0251-0215 91.2 µM -1.94052564260431 0.0199189516391818 no 3270 0.0261579204604698 4706 3888614
SGTC_1975 st070967 30.8 µM -1.94220743650079 0.0198331491139198 no 3271 0.0260559965997616 4650 261391
SGTC_2561 acetosyringone 100 µM -1.9481383096757 0.019533064452128 no 3272 0.0256992079739892 4630 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1735 st034310 56.75 µM -1.96993526603046 0.0184631157274642 no 3273 0.0244228950184853 4677 871153
SGTC_1651 st011928 86.1 µM -1.97609888897102 0.0181697693592285 no 3274 0.0240717891227718 4682 720198
SGTC_2654 protoveratrine a 100 µM -1.97705926670552 0.0181244215231925 no 3275 0.0240174656814746 4706 5702278 A heart drug and vasodilator.
SGTC_1163 k060-0048 49.9 µM -1.98010229678701 0.0179813700297596 no 3276 0.023846017568635 4681 6809982
SGTC_3280 9140961 49.47 µM -1.98242172705611 0.0178729822243865 no 3277 0.0237160299241598 4687 4901226
SGTC_1486 3970-0793 4.53 µM -1.99481670341832 0.0173031603492126 no 3278 0.0230314374546352 4726 2844330
SGTC_3227 9130768 49.47 µM -1.998711173955 0.0171273584024155 no 3279 0.0228198066527351 4737 17720899
SGTC_3312 9133330 71.43 µM -2.00343069738295 0.0169163601960762 no 3280 0.0225655396478975 4694 17617324
SGTC_483 fpl-64176 144 µM -2.00556345374746 0.016821741494332 no 3281 0.0224514221882452 4758 3423
SGTC_170 4197-0004 226 µM -2.00836274658993 0.0166982394531288 no 3282 0.0223023792976757 4676 218692
SGTC_2514 salinomycin 42.74 µM -2.01268487792453 0.0165090751228844 no 3283 0.0220738956237259 4668 23682228 A polyether potassium ionophore.
SGTC_104 0074-0074 590.992 µM -2.01521097425322 0.0163993684872252 no 3284 0.0219412740726008 4613 3943124
SGTC_770 0389-1121 67.2 µM -2.02231286052123 0.0160942770524571 no 3285 0.021572020428765 4716 6753108
SGTC_261 5-fluorouridine 15.376 µM -2.02309863438858 0.0160608215984706 no 3286 0.0215314896633184 4693 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3077 9117319 49.47 µM -2.03396019626404 0.0156044463980691 no 3287 0.0209778044124232 4653 17154678
SGTC_54 0159-0055 9 µM -2.03563779287192 0.0155349596440825 no 3288 0.0208933699349988 4656 3319099
SGTC_1207 2099-0101 141 µM -2.04215560664737 0.0152675036409817 no 3289 0.0205680492343156 4700 5837381
SGTC_322 k048-0136 19.3 µM -2.05271736159012 0.0148425030303169 no 3290 0.0200499986162083 4724 6823282
SGTC_1480 1070-0044 41.2 µM -2.06317427042323 0.0144317839108772 no 3291 0.0195480368836387 4736 3124987
SGTC_2190 6049624 200 µM -2.06402120033342 0.0143989513100606 no 3292 0.0195078531733014 4646 2265554
SGTC_2540 epiandrosterone 100 µM -2.07681101603363 0.0139108981245168 no 3293 0.0189095025422024 4708 441302 A steroid.
SGTC_2681 menadione 3.18 µM -2.08427710705391 0.0136326418012201 no 3294 0.0185674842393918 4713 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_523 1934-0222 13.7 µM -2.08655086600949 0.0135488600805594 no 3295 0.0184643763294539 4686 1361595
SGTC_521 r062-0005 13.8 µM -2.09222247486028 0.0133418114093978 no 3296 0.0182093094577596 4643 2832033
SGTC_2563 tomatine 8.54 µM -2.10777210124626 0.0127881137634092 no 3297 0.017525353582149 4636 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_366 0181-0206 4.31 µM -2.1105874922777 0.0126900167463516 no 3298 0.0174038918393535 4664 274874
SGTC_71 0417-1750 47.813 µM -2.11970281925015 0.0123768642911332 no 3299 0.0170155575509587 4669 6811472
SGTC_1368 1852-0141 284 µM -2.13327950580226 0.0119228594685769 no 3300 0.0164509021922211 4668 2838987
SGTC_958 1222-0007 33 µM -2.13355019817956 0.0119139563643197 no 3301 0.0164398091836735 4726 7312461
SGTC_3335 9143315 29.6265 µM -2.13775035492111 0.0117765498591242 no 3302 0.0162685051152295 4713 4899691
SGTC_133 0724-0033 378.92 µM -2.15441708216524 0.0112447723860814 no 3303 0.015603739071158 4664 280309
SGTC_2911 7942208 15.64 µM -2.15689455130918 0.011167534111171 no 3304 0.0155069407925694 4691 1243384
SGTC_1921 5740136 50 µM -2.16652635504783 0.0108716166376095 no 3305 0.0151354940803854 4665 1774243
SGTC_2502 avocadyne acetate 18.59 µM -2.18263648882609 0.0103919067457355 no 3306 0.0145312952161903 4705 3952079
SGTC_966 1300-0360 30.2 µM -2.18502931059896 0.0103222531309735 no 3307 0.0144433487838565 4715 70588
SGTC_1282 0886-0010 32.4 µM -2.20654068210872 0.00971413382816584 no 3308 0.0136730825206727 4729 2836211 YNL267W PIK1
SGTC_209 4077-0173 175.592 µM -2.24083008983981 0.0088094316457513 no 3309 0.0125185415375334 4717 15993494
SGTC_2202 7226349 200 µM -2.25602783440987 0.00843266040507813 no 3310 0.0120344440010304 4759 844334
SGTC_300 r073-0011 5.04 µM -2.26373957909534 0.00824694282290803 no 3311 0.0117950683237066 4738 2735780
SGTC_2105 5350118 200 µM -2.27085732298484 0.00807872833630414 no 3312 0.0115778082441799 4723 2133313
SGTC_2850 9015429 58.44 µM -2.27107009945428 0.00807374652786657 no 3313 0.0115713673617033 4711 6457570
SGTC_1127 asiatic acid 681.4 nM -2.28147788844112 0.00783333834601695 no 3314 0.0112600918414432 4707 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1932 st074806 40.9 µM -2.30384530047995 0.00733788442993954 no 3315 0.0106156645806769 4743 17251235
SGTC_2575 plumbagin 510 nM -2.3051836482169 0.00730913488681722 no 3316 0.0105781451328489 4678 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2961 9083290 32.55 µM -2.31585955009699 0.00708333515917252 no 3317 0.0102829692594647 4714 17741490
SGTC_3333 9141820 12.094 µM -2.31670748143984 0.00706566775502468 no 3318 0.0102598358792885 4717 1939433
SGTC_760 0568-0725 82.9 µM -2.31749106509371 0.00704937567573726 no 3319 0.010238498405002 4735 3916171
SGTC_761 k216-0224 480 µM -2.32287761836107 0.00693827431188916 no 3320 0.0100928639036564 4745 1340404
SGTC_1381 2324-0066 62.1 µM -2.32779665056772 0.00683816938276064 no 3321 0.00996145201223419 4753 10885928
SGTC_1021 4476-0760 85.3 µM -2.36495224194065 0.00612236000091078 no 3322 0.00901619805896678 4752 746768
SGTC_602 3130-1533 38.1 µM -2.3791522410341 0.00586684358646066 no 3323 0.00867625382070483 4758 720941
SGTC_1281 0884-0031 11.8 µM -2.40648028388634 0.00540158534351965 no 3324 0.00805353671208292 4759 1548255
SGTC_2968 9090663 33.37 µM -2.4294914546649 0.00503556930123399 no 3325 0.0075600106715249 4716 25236811
SGTC_2419 paclitaxel 166.5 µM -2.45721729504271 0.00462401410159825 no 3326 0.00700089830505008 4719 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3070 9117005 49.47 µM -2.47592506766173 0.00436355206758676 no 3327 0.0066445732929512 4782 8779016
SGTC_368 fentichlor 4.58 µM -2.47633758227945 0.00435795954848931 no 3328 0.00663690019855133 4745 7329 A pesticide.
SGTC_3353 9151644 39.2805 µM -2.49034723246892 0.00417179132425406 no 3329 0.0063809173010755 4758 4909158
SGTC_1640 st009078 66.4 µM -2.54059415612805 0.00356120524437071 no 3330 0.00553321460893144 4778 690618
SGTC_377 3970-0964 33.1 µM -2.55096636528243 0.00344563822228739 no 3331 0.00537123462371252 4768 16481235
SGTC_3304 9125678 46.087 µM -2.55969325045802 0.00335102554169402 no 3332 0.00523822950817865 4756 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_53 0973-0023 39.979 µM -2.58011999574389 0.0031386368963434 no 3333 0.00493829947126506 4729 674768
SGTC_2495 cafestol 54.53 µM -2.58172680209279 0.00312245549854916 no 3334 0.0049153686219878 4749 16667697 An anti-infammatory.
SGTC_296 1222-0039 74.9 µM -2.58917880553732 0.00304838741076598 no 3335 0.00481025627877785 4786 5984176
SGTC_2636 apigenin dimethyl ether 100 µM -2.59891635098341 0.00295398856433807 no 3336 0.00467592794711217 4731 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_134 0269-0018 6.916 µM -2.60897933161989 0.00285921078062916 no 3337 0.00454063635887118 4742 4378915
SGTC_2937 9044753 11.33 µM -2.610266833533 0.00284728448835559 no 3338 0.00452358116693106 4737 6465530 YGL099W LSG1
SGTC_272 doxorubicin 8.13 µM -2.6289043945788 0.00267959695113882 no 3339 0.004283021982294 4779 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_301 4119-0100 24.5 µM -2.63371583837755 0.0026377808667518 no 3340 0.00422280687934807 4780 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_43 0570-0105 72.5 µM -2.66513876640991 0.00237887650629823 no 3341 0.00384782801058009 4744 1114046 YDL195W SEC31
SGTC_820 1582-0060 59.9 µM -2.67730478356093 0.00228497527720358 no 3342 0.0037108544000447 4782 3848840
SGTC_1179 1021-1431 9.29 µM -2.69546017596113 0.00215108008984588 no 3343 0.00351457398463937 4783 2840958
SGTC_109 0132-0036 33.701 µM -2.72089299567255 0.00197546728232388 no 3344 0.00325529161624153 4760 67274 A color developer.
SGTC_108 0509-0257 621.132 µM -2.79034712259853 0.0015601852521536 no 3345 0.00263257793399709 4776 536624
SGTC_1287 0971-0001 34.6 µM -2.82964493097036 0.00136212909927081 no 3346 0.00232998443295742 4787 4665869
SGTC_129 0088-0017 176.636 µM -2.8435441887922 0.00129777094992637 no 3347 0.00223074111817785 4740 182446
SGTC_311 1315-0136 58 µM -2.85898023225434 0.00122956392647859 no 3348 0.0021250263405829 4794 6759207
SGTC_656 4090-1979 187 µM -3.11147014307151 0.000490738599654595 yes 3349 0.000930791489414334 4802 22330961
SGTC_3341 9147222 25.867 µM -3.17056871589704 0.000391996506605222 yes 3350 0.000760704218612145 4798 1939759
SGTC_1790 st045711 43.5 µM -3.32592172092064 0.000213388048495415 yes 3351 0.000440633371542428 4798 585119
SGTC_2587 piperic acid 92.2 µM -3.32710087136975 0.000212384621432694 yes 3352 0.000438773006276409 4791 5370536
SGTC_213 1246-0773 967 nM -3.46272595928762 0.000122293899754537 yes 3353 0.000267366355869641 4802 6251622
SGTC_2956 9076196 2.52 µM -3.5197227612571 9.64120611402492e-05 yes 3354 0.000215999048980894 4796 16423868
SGTC_2993 9054257 71.4286 µM -3.61206193291367 6.51079713289836e-05 yes 3355 0.000151885995220096 4792 6470217 YGL055W OLE1
SGTC_2583 asiatic acid 100 µM -5.28265454375061 1.09882954922206e-08 yes 3356 6.36626734585573e-08 4807 5320556 A kinase inhibitor; arrests cells at G2/M.