SGTCid condition conc unit YJL055W|YJL055W.score YJL055W|YJL055W.strain.pval YJL055W|YJL055W.strain.significant YJL055W|YJL055W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2932 9016711 44.54 µM 10.7885021238788 3.83801972696647e-27 yes 1 1.95047802639766e-27 6 7117328
SGTC_1434 4073-0095 163 µM 6.4181108135378 8.91879470902839e-11 yes 2 6.89879058942699e-11 1 24133745
SGTC_1524 corynanthine 62.1 µM 6.16412900995343 4.49857861521731e-10 yes 3 3.54360729044577e-10 5 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2939 9044578 71.43 µM 6.1449645205921 5.06995776903807e-10 yes 4 3.99906952038939e-10 14 2653634
SGTC_47 0149-0135 24.25 µM 5.71250125938454 6.85300007988041e-09 yes 5 5.56637961700524e-09 3 5239155
SGTC_3295 9122362 53.5725 µM 5.70217735727218 7.27645942239889e-09 yes 6 5.91433293484233e-09 2 4730473
SGTC_3349 9149703 23.001 µM 5.13524434538723 1.67309710776169e-07 yes 7 1.40888841991674e-07 4 4910494
SGTC_66 0109-0187 42.4 µM 4.93555693598351 4.6905175436914e-07 yes 8 3.9961179969082e-07 21 759417
SGTC_1442 4112-3290 3 µM 4.91594977732801 5.17948798682582e-07 yes 9 4.41765239814212e-07 1 704353
SGTC_679 0422-0091 41.4 µM 4.7549719245901 1.1530174576447e-06 yes 10 9.92369984733767e-07 13 627384 YHR062C RPP1
SGTC_1739 st037196 92.5 µM 4.68767083530249 1.59939012005935e-06 yes 11 1.38166002094666e-06 9 612214
SGTC_1002 4049-0206 172 µM 4.55256599561512 3.04505466959845e-06 yes 12 2.64977642213379e-06 16 4662749
SGTC_75 0159-0059 199.013 µM 4.53741754818791 3.2694821423345e-06 yes 13 2.84736419561331e-06 14 5377270
SGTC_1370 2001-0092 44.6 µM 4.19374176661456 1.54781515518373e-05 yes 14 1.37195167113775e-05 22 790957
SGTC_1952 st077036 64.1 µM 4.18898619429168 1.58023479554213e-05 yes 15 1.40101722003778e-05 28 2937007
SGTC_1578 josamycin 24.2 µM 4.00231132392565 3.5056876761616e-05 yes 16 3.13633426079526e-05 13 5282165 A P450 substrate.
SGTC_1822 st052468 42 µM 3.98479956275626 3.77140462905064e-05 yes 17 3.3768554304818e-05 10 2873678
SGTC_1148 3909-7663 27.7 µM 3.9602984304169 4.17528914140356e-05 yes 18 3.74280779707733e-05 17 4084526
SGTC_1441 4106-0040 13 µM 3.95614780711379 4.24763445415438e-05 yes 19 3.80840223128133e-05 9 2904180
SGTC_1287 0971-0001 34.6 µM 3.94033369608644 4.53427429369892e-05 yes 20 4.06841716592617e-05 45 4665869
SGTC_2929 9013348 24.6 µM 3.91082754993736 5.11858588855728e-05 yes 21 4.59902147477757e-05 20 2995952
SGTC_2802 7925815 54.55 µM 3.85288936221854 6.47862561621165e-05 yes 22 5.83660720927288e-05 46 1262923
SGTC_1288 0973-0013 65.5 µM 3.8225869196152 7.31911249976915e-05 yes 23 6.60294526380182e-05 17 4315430
SGTC_2416 tofa 880 nM 3.66228492845453 0.000137554662534175 yes 24 0.00012498779951671 61 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1045 1348-1485 165 µM 3.58715613604636 0.000183358470080866 yes 25 0.000167152080829499 48 6810614
SGTC_1193 1488-0126 41.5 µM 3.57885855490222 0.000189211167752116 yes 26 0.000172549084536494 36 1384710
SGTC_2450 5739737 12.93 µM 3.5361063017621 0.000222234925268924 yes 27 0.0002030356297044 39 2262825
SGTC_1281 0884-0031 11.8 µM 3.41262022623148 0.000350311903346976 yes 28 0.000321707694196916 41 1548255
SGTC_874 0599-0792 117 µM 3.40130940456107 0.000364963812639255 yes 29 0.000335319378985062 49 765305
SGTC_1967 st070177 51.4 µM 3.37495029042339 0.00040134617176338 yes 30 0.000369145126319052 33 5729214
SGTC_1673 st016611 27.3 µM 3.36835615437142 0.000410959865255542 yes 31 0.000378089221706485 70 5226799
SGTC_2585 alliin 100 µM 3.32398969313032 0.000481405228059693 yes 32 0.00044369737751992 51 87310 A garlic compound which reacts with lipids.
SGTC_322 k048-0136 19.3 µM 3.31797851287971 0.000491767021995237 yes 33 0.000453357296387767 30 6823282
SGTC_1914 st062367 72.6 µM 3.28801696481437 0.000546562810021812 yes 34 0.000504478796934872 42 978205
SGTC_346 4513-0042 7.16 µM 3.23269387717555 0.000662838258738601 yes 35 0.000613144465038819 68 2827372
SGTC_2893 9048488 25.97 µM 3.1981726201015 0.000746542146851929 yes 36 0.000691507333164476 49 6467338
SGTC_550 4123-0385 25.7 µM 3.13339201112982 0.00093042256553932 yes 37 0.000863992450137675 65 5731123
SGTC_1731 st035964 63 µM 3.11916070121334 0.000976028062922052 yes 38 0.000906835066459471 70 6739575
SGTC_825 1988-2224 89.6 µM 3.10993115630142 0.00100669262218962 no 39 0.000935654766919673 71 1180859
SGTC_1999 st074831 12.5 µM 3.08841500174418 0.00108164179718686 no 40 0.0010061362384205 75 17112523
SGTC_695 3505-6186 243 µM 3.08030247791351 0.00111120462752774 no 41 0.00103395233014739 53 1819379
SGTC_3233 9132340 49.47 µM 3.07090626174187 0.00114636980769304 no 42 0.00106705069292678 56 17682950
SGTC_678 1218-2179 85.9 µM 3.06598855067711 0.00116517790249797 no 43 0.00108475811140389 16 6820081 YOR116C RPO31
SGTC_2067 5224629 34.075 µM 3.05017476241611 0.00122759046502018 no 44 0.00114354120521047 59 2835000
SGTC_1930 st074634 34.3 µM 3.01039866394354 0.00139833449742385 no 45 0.00130452496202509 78 684253 YOR116C RPO31
SGTC_1289 0976-0073 69.1 µM 3.00068799982373 0.00144318727116302 no 46 0.00134685206546193 52 3391136
SGTC_3340 9146634 11.102 µM 2.99861967668541 0.00145290873256096 no 47 0.00135602809682345 56 4907387
SGTC_924 2046-0044 21.3 µM 2.98313803866326 0.00152759441675671 no 48 0.00142654642137833 47 3623589
SGTC_1443 4112-3303 14 µM 2.97887575259763 0.00154876224167508 no 49 0.00144654032305799 40 704433
SGTC_331 k048-0133 24.5 µM 2.97577661051246 0.00156432109380528 no 50 0.00146123829651009 41 6813582
SGTC_3140 9094243 49.47 µM 2.96363546444371 0.00162665639744197 no 51 0.00152014105841604 71 19291112
SGTC_482 fipronil 114 µM 2.95756781443507 0.0016586497255903 no 52 0.00155038267491378 22 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1174 0739-0097 51.1 µM 2.95732468217232 0.00165994356821345 no 53 0.00155160581686317 82 728447
SGTC_2464 5717415 7.67 µM 2.95553103796263 0.00166951699174744 no 54 0.00156065644677756 59 5285744
SGTC_1072 oxiconazole 14.9 nM 2.94600952237033 0.00172118439629341 no 55 0.00160951245051598 96 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2394 5221648 200 µM 2.9255784720306 0.00183699608131765 no 56 0.00171908225997501 76 788586
SGTC_2294 7971431 200 µM 2.91703982698824 0.00188746216218722 no 57 0.00176685324247399 58 5741572
SGTC_24 0417-1663 219 µM 2.87453369032179 0.00215793797487252 no 58 0.00202312299605884 62 4329390
SGTC_3079 9117512 49.47 µM 2.86715414524512 0.00220832580581499 no 59 0.0020709061319466 15 7185044
SGTC_2265 7929201 200 µM 2.8168564972106 0.00258113289908353 no 60 0.00242480943399285 81 1265108
SGTC_272 doxorubicin 8.13 µM 2.75250263992866 0.00314071083749253 no 61 0.00295708347966387 111 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1456 k015-0012 13 µM 2.7362697638144 0.00329810711427213 no 62 0.00310700309019463 96 2989616
SGTC_1985 st071382 65.5 µM 2.70160136561009 0.0036582331769763 no 63 0.00345032210782958 80 6123237
SGTC_2401 5128683 200 µM 2.6850424056925 0.00384238482173743 no 64 0.00362603021661565 106 708373
SGTC_2360 9040895 200 µM 2.66781284396752 0.00404277282690709 no 65 0.00381733869116963 91 4914414
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.65236960587213 0.00423028225079945 no 66 0.00399644968753887 114 6708561
SGTC_667 1498-1044 59 µM 2.63976569410635 0.00438904084080573 no 67 0.00414816816628726 98 6739982
SGTC_865 0488-0499 301 µM 2.62448213061232 0.00458867982169389 no 68 0.00433904230776259 78 9634651
SGTC_1371 2421-0008 32.7 µM 2.62248356604348 0.00461537622791441 no 69 0.00436457387977283 139 2827552
SGTC_3036 9090181 49.47 µM 2.6096514495334 0.00479011143086043 no 70 0.00453172584454835 50 25236586
SGTC_1213 1315-0166 115 µM 2.60157117410563 0.00490314440554345 no 71 0.0046398903536221 107 768401
SGTC_2253 7938677 135.83 µM 2.59370255201406 0.00501549469986983 no 72 0.0047474296040215 77 2301972
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.59102088331558 0.00505430486243453 no 73 0.00478458422207154 139 1273210
SGTC_1264 0783-0040 158 µM 2.57315691722581 0.00531973298172295 no 74 0.00503877527727853 110 2855798
SGTC_2063 5246145 200 µM 2.56559731301677 0.00543573959725575 no 75 0.00514991626331729 112 711240
SGTC_2048 5246248 200 µM 2.56210485537706 0.00549008872165161 no 76 0.00520199512134683 61 677046
SGTC_1454 4239-0054 42.6 µM 2.55975219844928 0.00552697210181312 no 77 0.00523734114372051 129 1340767
SGTC_928 2764-0428 58.7 µM 2.55465546391452 0.00560763123817258 no 78 0.00531464756884985 158 662578
SGTC_1841 st054148 70 µM 2.55346550283995 0.00562661301049591 no 79 0.00533284217512073 96 675442
SGTC_3316 9136639 10.545 µM 2.55254233764597 0.00564137824411642 no 80 0.00534699558177264 89 4903665
SGTC_2593 nobiletin 86.24 µM 2.5368718969441 0.00589731586276583 no 81 0.00559239368240168 115 72344 An anti-infammatory.
SGTC_3328 9140624 29.0385 µM 2.53326036038236 0.00595774174541759 no 82 0.00565034903195217 111 4904392
SGTC_1941 st076221 61.8 µM 2.51737731014095 0.00623005148751023 no 83 0.00591160696650573 210 2828568
SGTC_1221 2958-7315 257 µM 2.51483877518214 0.00627458071984832 no 84 0.00595434141976175 99 4562705
SGTC_371 0195-0006 7.36 µM 2.49936793835284 0.00655210152180004 no 85 0.00622075304936906 99 3928593
SGTC_1549 4'-methoxyflavonol 74.6 µM 2.49542844433623 0.00662448088962404 no 86 0.00629025630270727 83 97141
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.46676894852033 0.00717264913025102 no 87 0.0068169149671114 100 803109
SGTC_2382 9035899 200 µM 2.46174157415335 0.00727282725864774 no 88 0.00691321252358408 106 6462679
SGTC_1406 3909-7906 11.9 µM 2.4568538588943 0.00737140311673635 no 89 0.0070079845332132 113 X1406
SGTC_2513 baicalein 25.65 µM 2.44852875987204 0.00754201736107548 no 90 0.00717204889993237 118 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_815 1582-0027 36.9 µM 2.44613989012803 0.00759161264897597 no 91 0.00721974814764896 126 3128206
SGTC_2516 gossypol 71.55 µM 2.41277089423318 0.00831501461174233 no 92 0.00791588384898161 127 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_414 piperonyl butoxide 100 µM 2.40689906667293 0.00844838904964836 no 93 0.00804430784515131 98 5794 A potent inhibitor of cytochrome P450.
SGTC_3286 9117135 37.221 µM 2.4014661625631 0.00857346230477018 no 94 0.00816475961471032 122 3438150
SGTC_1966 st070145 16.1 µM 2.37511923839317 0.00920332071896434 no 95 0.00877164097380557 129 3748532
SGTC_1175 0741-0056 27.6 µM 2.37459755367098 0.0092161908164851 no 96 0.00878404658323606 157 765927
SGTC_2393 9031399 185.94 µM 2.3688919579253 0.00935798084285892 no 97 0.00892073224215928 163 1526623 YDL150W RPC53
SGTC_100 0086-0128 49.5915 µM 2.36319985780951 0.00950133337374529 no 98 0.00905894795526241 192 93297
SGTC_1179 1021-1431 9.29 µM 2.36218542087201 0.00952708203550198 no 99 0.00908377646068884 197 2840958
SGTC_3172 9105863 49.47 µM 2.35690758563166 0.00966203192387475 no 100 0.00921391612540877 48 2348785
SGTC_1961 st076550 68.7 µM 2.3308654164252 0.010352645415282 no 101 0.00988022868959457 123 1579337
SGTC_837 0091-0265 12.5 µM 2.30642848597602 0.0110394354606092 no 102 0.0105433509079291 151 759367
SGTC_860 0443-0016 25.1 µM 2.2947015598613 0.0113828594839342 no 103 0.0108751166769359 145 5337942
SGTC_765 1319-0117 244 µM 2.29211489957343 0.0114598476265718 no 104 0.0109495069249929 124 3487746 YGL099W LSG1
SGTC_2507 purpurin 79.67 µM 2.28069768425176 0.0118050929927155 no 105 0.0112831711502979 186 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2283 7944793 200 µM 2.27600813051378 0.0119494943744727 no 106 0.0114227614954079 195 2970533
SGTC_513 4245-1575 41.7 µM 2.27544395016417 0.0119669695099316 no 107 0.0114396557058537 315 719745
SGTC_2404 5161160 200 µM 2.27290620011652 0.0120458490837281 no 108 0.0115159165489199 161 2831543
SGTC_787 4152-0075 138 µM 2.26323826503415 0.0123504967650805 no 109 0.0118105027923689 141 9566539
SGTC_3169 9102970 49.47 µM 2.25290575457792 0.012683442249445 no 110 0.0121325459793474 87 17027839
SGTC_1829 berberine 14.4 µM 2.24574453292288 0.0129187311078656 no 111 0.0123601879766064 143 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1078 idebenone 36.1 µM 2.24318595237952 0.0130037061625767 no 112 0.0124424128920585 236 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1202 1988-0068 29.6 µM 2.23379878685144 0.0133196224782588 no 113 0.0127481577065661 186 2850480
SGTC_2710 st078562 53.7235 µM 2.22244696893852 0.0137104936532251 no 114 0.0131265570690951 147 17250908
SGTC_2406 ethylparaben 405.7 µM 2.21637492956032 0.0139236025457096 no 115 0.0133329176066165 181 8434 A possible steroid mimic.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.20945161042679 0.0141700674985254 no 116 0.0135716223146241 161 2374 Ca(2+)-ATPase inhibitor.
SGTC_95 0471-0001 561.058 µM 2.19833665422045 0.0145736126975836 no 117 0.0139625620953794 178 4015405
SGTC_2885 9057732 51.95 µM 2.18780962657718 0.0149648925340818 no 118 0.0143417361882894 160 6471414
SGTC_850 0388-0143 75.9 µM 2.18482874490874 0.0150773166217382 no 119 0.0144507027947935 161 67273
SGTC_400 oxethazaine 37.5 µM 2.18197369960917 0.0151856745112861 no 120 0.0145557369186344 166 4621 A local anesthetic.
SGTC_1160 4092-0570 10.5 µM 2.16624084392022 0.0157948620762656 no 121 0.0151463937615024 214 4994975
SGTC_556 4058-0063 51.5 µM 2.16479771446257 0.0158517762774455 no 122 0.01520158996544 168 6615692
SGTC_2388 9080168 200 µM 2.16378649465827 0.0158917615162093 no 123 0.0152403695553502 129 15943073
SGTC_141 0443-0274 32.331 µM 2.16254995912846 0.0159407736006448 no 124 0.0152879053088427 295 1627241
SGTC_1476 4112-3294 3.34 µM 2.15979199523802 0.0160505570016229 no 125 0.0153943878032034 145 704369
SGTC_724 3910-0327 137 µM 2.1482471169799 0.0165171730670506 no 126 0.0158470647516169 179 2885483
SGTC_1116 jasmonic acid 1.58368 µM 2.14365142032731 0.0167061253535455 no 127 0.0160304136968651 191 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1562 morin hydrate 59.1 µM 2.14103902775006 0.0168143561390709 no 128 0.016135445452046 169 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1745 st081495 74 µM 2.13310970942934 0.0171465458093069 no 129 0.0164578637395487 290 13842402 YBL026W LSM2
SGTC_2078 5212016 200 µM 2.12841921488582 0.0173456764276408 no 130 0.0166511707045619 139 1899708
SGTC_1969 st069479 40.1 µM 2.12743584143344 0.0173876741718164 no 131 0.0166919434064152 145 3895485
SGTC_192 3455-0609 60.9 µM 2.09470780349015 0.0188357987411317 no 132 0.0180984875622044 172 3769639
SGTC_2990 9074105 71.4286 µM 2.09291437102864 0.0189180345985488 no 133 0.018178399569829 160 6502001
SGTC_525 k781-2675 26.7 µM 2.08878641360255 0.0191084786795012 no 134 0.0183634769803501 240 3651118 YDL195W SEC31
SGTC_2449 5812982 45.77 µM 2.08739940016821 0.0191728335860216 no 135 0.0184260230780714 145 776185
SGTC_995 3931-2021 34.6 µM 2.08704580822032 0.0191892690521956 no 136 0.0184419969749237 190 730143
SGTC_1419 3993-2473 62.6 µM 2.08246882937364 0.0194030967817577 no 137 0.0186498335901738 187 704026
SGTC_555 4296-0685 37 µM 2.07830344160167 0.0195994519058225 no 138 0.0188407098357524 185 2908540 YHR072W ERG7
SGTC_1826 st055655 41.6 µM 2.07611714904679 0.0197031866114025 no 139 0.0189415587312494 223 676168
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.07083531777908 0.01995572257941 no 140 0.0191870942471097 232 5379071
SGTC_1795 st049545 62.3 µM 2.06384094697054 0.0202943605123309 no 141 0.0195163996504235 155 5291882
SGTC_302 1094-0063 18.9 µM 2.05097462197349 0.0209300222852422 no 142 0.0201347091137872 150 5440289
SGTC_2715 st079500 56.4 µM 2.05044084673036 0.0209567535362152 no 143 0.0201607153212041 172 28246688
SGTC_2971 9092186 9.93 µM 2.0480174465089 0.0210784801236977 no 144 0.0202791449678631 201 25236400
SGTC_1241 0364-0022 50.8 µM 2.04273394866406 0.0213459435569768 no 145 0.0205393911208907 228 4563895
SGTC_1465 k213-0056 144 µM 2.04024976814085 0.0214726872553167 no 146 0.0206627275592031 207 24048857 YMR208W ERG12
SGTC_2553 4-methylesculetin 85.09 µM 2.03414529770507 0.0217868440519753 no 147 0.0209684739909556 217 5319502
SGTC_2350 9023895 38.85 µM 2.02773529757421 0.0221208942637095 no 148 0.0212936355424509 215 2997209
SGTC_1798 st045719 60.953 µM 2.02428027100527 0.0223027352623069 no 149 0.0214706611975608 147 3980186
SGTC_509 pifithrin 175 µM 2.02426633021481 0.0223034715247266 no 150 0.02147137799598 148 4817 A p53 inhibitor.
SGTC_856 0433-0016 11.3 µM 2.02179526522375 0.0224343015378691 no 151 0.0215987535647107 211 3911780
SGTC_3026 9090633 49.47 µM 2.02009551242059 0.022524669823063 no 152 0.0216867406297373 205 25236842
SGTC_771 0250-0039 27.3 µM 2.01697421741482 0.0226914145517774 no 153 0.0218491019908175 194 3005115
SGTC_3122 9126309 49.47 µM 2.01214985543879 0.0229511860535996 no 154 0.0221020712827417 171 17591206
SGTC_1046 2001-0062 216 µM 2.01099397113255 0.0230137961847487 no 155 0.0221630467628752 221 739778
SGTC_786 4544-0069 423 µM 2.00791640681574 0.0231811986122969 no 156 0.0223260877044089 245 748821 YLR208W SEC13
SGTC_3236 9132701 49.47 µM 2.00757430651115 0.0231998701246011 no 157 0.0223442735714331 206 24282524
SGTC_2271 7849410 118.62 µM 2.00218185045539 0.0234958619212851 no 158 0.0226325884754679 203 972430
SGTC_36 0335-0881 14.2 µM 1.99763561395809 0.0237478669854122 no 159 0.0228780896196035 331 23828853
SGTC_1212 0520-0165 585 µM 1.99396603465826 0.0239529314869905 no 160 0.023077883248386 231 5403258
SGTC_3084 9116877 49.47 µM 1.99132307754554 0.0241015461211452 no 161 0.0232226899637426 140 27241325
SGTC_2043 5101342 149 µM 1.98840888046619 0.0242663098836627 no 162 0.0233832437210871 229 678451
SGTC_1902 st060212 70.5 µM 1.98191376467662 0.0246369383865192 no 163 0.0237444465502799 217 688944
SGTC_576 1073-0113 22.7 µM 1.98186230066621 0.0246398939203166 no 164 0.0237473271661539 352 5439563
SGTC_1612 st002233 45.4 µM 1.97828954401376 0.0248458026946875 no 165 0.023948025998812 220 1035021
SGTC_2822 7994718 71.43 µM 1.9761768603399 0.0249682406476211 no 166 0.0240673748517281 187 1018011
SGTC_906 1165-0455 526 µM 1.97457711725597 0.0250612879743273 no 167 0.024158078989374 181 3252859
SGTC_2438 5259590 200 µM 1.97240605666656 0.0251880301303181 no 168 0.0242816354955613 212 1201127
SGTC_1329 1447-1697 50.6 µM 1.96860089127325 0.0254114637460937 no 169 0.0244994700766261 244 2840515
SGTC_931 2812-0076 566 µM 1.96713603578434 0.0254979192946586 no 170 0.0245837648997486 239 3450959
SGTC_2686 alizarin 95.37 µM 1.96402033526699 0.0256826268071999 no 171 0.0247638668560529 220 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_909 3448-9333 149 µM 1.96364168352242 0.0257051504922879 no 172 0.0247858299230554 200 3344074
SGTC_1685 st024049 53.0905 µM 1.93602826448828 0.0273928468684226 no 173 0.0264321196690895 202 1941139
SGTC_508 roscovitine 141 µM 1.92602800523806 0.0280264128182167 no 174 0.0270504385453736 177 160355 A CDKinase inhibitor.
SGTC_2281 7943571 200 µM 1.92571472778806 0.0280464559951241 no 175 0.0270700019446634 226 1244024
SGTC_1523 st012844 44.7 µM 1.92196455555513 0.0282873162873243 no 176 0.0273051089172122 248 4274103
SGTC_216 k038-0035 28.382 µM 1.91953285329113 0.0284444141325078 no 177 0.0274584663176481 213 4444231 YPR107C YTH1
SGTC_2136 5328288 199.296 µM 1.9131993888814 0.0288569920362711 no 178 0.0278612658677645 209 262395
SGTC_1986 st071812 45 µM 1.91157678422239 0.0289634894463031 no 179 0.0279652497192375 185 11838594
SGTC_859 0439-0102 54.6 µM 1.9115633462696 0.0289643727896681 no 180 0.0279661122317791 246 610143
SGTC_347 4534-1311 26.2 µM 1.90966261924117 0.0290895427650905 no 181 0.0280883334441919 224 2862016
SGTC_2634 4'-methoxyflavone 100 µM 1.90779886001131 0.0292127143537453 no 182 0.0282086090891026 239 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2701 st077767 14.721 µM 1.90311250264809 0.0295243402148624 no 183 0.028512933439719 301 5721188
SGTC_484 loperamide 105 µM 1.90279628769997 0.0295454663726554 no 184 0.0285335659079058 123 3955 An opioid-receptor agonist.
SGTC_1352 1496-0991 99 µM 1.90132408235325 0.0296439889192642 no 185 0.0286297882927106 259 3000039
SGTC_2206 7254556 146.969 µM 1.89503583080254 0.0300678839163257 no 186 0.0290438274366821 162 4398905
SGTC_2756 carbadox 75.1 µM 1.88293062803499 0.0308980552965543 no 187 0.0298548849328281 330 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1165 k072-0275 30.3 µM 1.87621585236463 0.0313666750120718 no 188 0.0303128230884467 255 6153523 YGL055W OLE1
SGTC_656 4090-1979 187 µM 1.87068426380703 0.0317571218365865 no 189 0.0306944286148313 282 22330961
SGTC_2853 9015042 58.44 µM 1.86848773268813 0.031913273652878 no 190 0.0308470592260997 225 6457456
SGTC_2348 9022543 33.42 µM 1.86810369357598 0.0319406400893483 no 191 0.0308738094126782 269 3162678 YDL140C RPO21
SGTC_1724 st037281 8.293 µM 1.86727608858015 0.0319996807000895 no 192 0.0309315213914063 296 574124 YDL195W SEC31
SGTC_1845 st056753 3.01 µM 1.86661058097738 0.0320472227717543 no 193 0.030977994454988 292 5375839
SGTC_1778 st046819 58.9 µM 1.85924214813969 0.0325775117362845 no 194 0.0314964115171245 324 671715
SGTC_469 w7 172 µM 1.84856575262669 0.0333586885857355 no 195 0.0322602708621982 167 45115570 A P450 inhibitor.
SGTC_2086 5274770 176.623 µM 1.8447224926823 0.0336436433932326 no 196 0.032538958596045 276 689278
SGTC_3147 9097027 49.47 µM 1.83930482776121 0.0340487303706259 no 197 0.0329351816841246 272 25236841
SGTC_2962 9082311 13.18 µM 1.83827668183527 0.0341260573839847 no 198 0.0330108226670851 244 16459453
SGTC_1025 k007-0731 70 µM 1.83694105013761 0.0342267260053917 no 199 0.0331092991839185 266 6256118
SGTC_3192 9110362 49.47 µM 1.8328232962494 0.0345386248491791 no 200 0.0334144267580787 249 16649480
SGTC_3184 9108758 49.47 µM 1.83182521797064 0.0346145747082578 no 201 0.0334887324221977 222 902885
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.79968224181729 0.037134807129089 no 202 0.035955413347154 315 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2059 5238311 157 µM 1.79918900598119 0.0371746183728707 no 203 0.0359943939685848 280 703021
SGTC_3134 9127454 49.47 µM 1.79876971188501 0.0372084888717334 no 204 0.0360275581589428 240 24262820
SGTC_781 4335-2806 94.4 µM 1.79789142773946 0.0372795182308629 no 205 0.0360971074196669 318 845254
SGTC_3158 9100007 49.47 µM 1.79608775334986 0.0374257339046991 no 206 0.0362402809173662 238 19297233
SGTC_2030 5175110 200 µM 1.79231323871152 0.0377332324438913 no 207 0.0365414019106281 263 2831986
SGTC_2012 4023501 200 µM 1.79158309005928 0.0377929528893896 no 208 0.0365998869246354 282 3477460
SGTC_1888 azatryptophan 97.5 µM 1.78824825348988 0.0380666979507681 no 209 0.0368679821898136 237 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2640 pentamidine 10.38 µM 1.7859129937648 0.0382593524434537 no 210 0.0370566733834691 324 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2173 5763948 167 µM 1.77253815954553 0.0393781204151408 no 211 0.0381526333708118 292 2867177
SGTC_1424 4048-1941 275 µM 1.77213503035328 0.0394122499467388 no 212 0.0381860726109651 321 X1424
SGTC_1386 3228-0095 33.8 µM 1.76992113327373 0.0396001110692473 no 213 0.0383701398822917 267 870181
SGTC_2984 9022109 38.96 µM 1.75149445448447 0.0411921242986329 no 214 0.0399303878436573 209 6459207
SGTC_3035 9091303 49.47 µM 1.75011701489106 0.0413131863959535 no 215 0.0400490621663885 238 25237002
SGTC_3092 9117248 49.47 µM 1.74775326361749 0.0415216066331618 no 216 0.0402533806650317 223 17141857
SGTC_2141 5621638 7.665 µM 1.74619721659585 0.0416592731724089 no 217 0.0403883441625171 279 2856238
SGTC_1964 st076914 61 µM 1.74348001825023 0.0419005554029787 no 218 0.0406249008337227 263 24208661
SGTC_2005 4024620 188 µM 1.74040707677141 0.0421747890075201 no 219 0.0408937818933116 286 236743
SGTC_2187 6125751 200 µM 1.73364739730357 0.0427831445594541 no 220 0.0414903326019582 309 874498
SGTC_1500 4488-1866 171 µM 1.72745372028184 0.0433467696640575 no 221 0.0420431049515963 328 2900003
SGTC_2511 berberine 10.47 µM 1.72712428183457 0.0433769157188128 no 222 0.0420726727938141 284 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2112 5488546 200 µM 1.72234114145123 0.0438165183691567 no 223 0.0425038695425967 337 600757
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.72138023609063 0.0439052640722276 no 224 0.0425909241288946 261 6857784
SGTC_2371 9071574 200 µM 1.71862963518758 0.0441601011816534 no 225 0.0428409159675245 254 45596039
SGTC_3325 9138760 55.175 µM 1.71248719510607 0.0447334899624006 no 226 0.0434034611938751 324 43844959
SGTC_105 0111-0055 734.78 µM 1.70817769241738 0.0451393437891047 no 227 0.0438016882014528 255 5179370
SGTC_819 1013-0258 27.7 µM 1.70745897294957 0.045207317659022 no 228 0.0438683885975216 345 5753198
SGTC_1514 1189-1591 158 µM 1.70125721164442 0.0457972848588407 no 229 0.0444473494588133 394 767698 YMR146C TIF34
SGTC_3322 9139058 2.11 µM 1.70053830425285 0.0458660721809185 no 230 0.0445148589004218 319 4908926 YPR165W RHO1
SGTC_686 1319-0111 510 µM 1.69789904403564 0.0461193170830453 no 231 0.0447634088673317 342 4562600
SGTC_2431 5490079 200 µM 1.69413399001501 0.0464825277867527 no 232 0.0451199123647957 332 5722345
SGTC_1204 4049-0315 18.3 µM 1.68983484581226 0.0469000653535975 no 233 0.0455297776468664 339 588402
SGTC_294 k038-0071 157 µM 1.68140619721877 0.0477273920861446 no 234 0.0463420213116245 375 24152826
SGTC_1495 4469-0029 237 µM 1.68067941012825 0.047799274885841 no 235 0.0464126010158331 482 793680
SGTC_591 4299-0174 154 µM 1.67755506093124 0.0481092761406174 no 236 0.0467169959990661 296 5509088
SGTC_1738 st035555 74 µM 1.67711342899294 0.0481532248204768 no 237 0.0467601516432712 368 5331140
SGTC_2566 crystal violet carbinol 226 nM 1.6746907042681 0.0483948922958397 no 238 0.0469974661148255 304 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1950 st077106 7.18 µM 1.66725513921377 0.0491426536931704 no 239 0.0477318414090036 354 13831864
SGTC_88 0180-0332 8.668 µM 1.66699818565441 0.0491686583939132 no 240 0.0477573828222336 350 3101745
SGTC_1209 2323-2347 50.3 µM 1.66594411498621 0.0492754494810556 no 241 0.047862272936999 297 5412760
SGTC_399 oxolinic acid 75 µM 1.66554201402499 0.049316236314159 no 242 0.0479023343941853 301 4628 A DNA gyrase inhibitor.
SGTC_1488 4013-0813 75.9 µM 1.66547346322717 0.0493231924056162 no 243 0.0479091668112333 273 2910057
SGTC_3256 9138902 49.47 µM 1.66274577095815 0.0496006172885254 no 244 0.0481816679558242 253 17228773
SGTC_3161 9100388 49.47 µM 1.66227405932721 0.0496487196239621 no 245 0.0482289182897749 293 25236368
SGTC_878 0828-0289 13.7 µM 1.66117589756285 0.0497608478055048 no 246 0.0483390623933438 420 745350 YLR208W SEC13
SGTC_789 1309-1135 70.6 µM 1.65876356504334 0.0500078691612868 no 247 0.0485817224564962 376 3092424
SGTC_476 mead acid 10 µM 1.65411088736562 0.0504870615138634 no 248 0.0490524921848396 234 5312531 An omega 9 fatty acid.
SGTC_1450 4112-4260 37.6 µM 1.64445549260469 0.0514931683391781 no 249 0.0500410752878012 356 1633175
SGTC_305 1682-2595 20.8 µM 1.63958374977024 0.0520068290912241 no 250 0.0505458720764797 341 226033
SGTC_2897 9048598 12.99 µM 1.6380258889778 0.0521719411942356 no 251 0.0507081466650491 322 6467404
SGTC_873 0591-4978 488 µM 1.63798014438293 0.0521767957854626 no 252 0.050712917914288 368 3305145
SGTC_2673 kobusone 100 µM 1.6353702752808 0.0524543597161821 no 253 0.0509857248687678 281 6710676 An epoxy ketone and protein crosslinker.
SGTC_970 1315-0089 19.5 µM 1.6347270362745 0.0525229489888882 no 254 0.051053141099597 330 6811083 YLR033W RSC58
SGTC_2098 5376439 882.5 nM 1.63361344323904 0.0526418609056762 no 255 0.0511700216413252 372 2844116
SGTC_557 1315-0110 16.2 µM 1.63227026814086 0.0527855722394767 no 256 0.0513112818450887 363 6833801
SGTC_673 1082-0474 110 µM 1.62863526641812 0.0531760559869996 no 257 0.0516951269622693 442 3098046
SGTC_1647 st011722 22.4 µM 1.62607748894937 0.0534521908592534 no 258 0.0519665860695382 318 2854783
SGTC_918 glabranin 770.725 nM 1.62223790727885 0.0538688395612364 no 259 0.052376209001503 380 124049 Also referred to as licorice root.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.62095263616883 0.0540088826441269 no 260 0.0525138984700895 385 5393153
SGTC_1144 3486-0183 12.5 µM 1.61984922847452 0.0541293396726049 no 261 0.0526323342098068 379 6744069
SGTC_640 3381-0960 37.1 µM 1.61978622473417 0.054136224089068 no 262 0.0526391031926338 357 1745025
SGTC_3104 9120930 49.47 µM 1.6179983183422 0.054331877561895 no 263 0.0528314800390526 302 17014836
SGTC_215 1287-0124 461.5 µM 1.61637710295137 0.0545097729953055 no 264 0.0530064028832059 276 5560863
SGTC_672 1441-0018 53.7 µM 1.60967530751982 0.0552500516663115 no 265 0.0537343791444434 331 251141
SGTC_2709 st078560 56 µM 1.60856165579818 0.0553738311649553 no 266 0.0538561121465163 341 17250903
SGTC_2153 5569715 200 µM 1.60837140396335 0.0553949990456679 no 267 0.0538769303510373 334 2054701
SGTC_1084 voriconazole 435 nM 1.60711986055333 0.0555344081102166 no 268 0.0540140386830365 369 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2302 7771753 200 µM 1.60551499965059 0.055713578217151 no 269 0.054190257439926 421 2203047
SGTC_2607 solasodine 47.35 µM 1.60503516468421 0.0557672365135125 no 270 0.0542430330768308 416 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1728 st035614 33.7865 µM 1.60047373438807 0.0562793642273155 no 271 0.0547467645974126 447 15945546
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.59983351240245 0.0563515399565643 no 272 0.0548177611025884 387 5282309
SGTC_592 k241-0073 46.5 µM 1.59934248808406 0.0564069452388674 no 273 0.0548722618410899 377 4230158
SGTC_343 4130-2827 29.8 µM 1.59796148225634 0.0565630027962396 no 274 0.0550257747835076 393 1118244
SGTC_1691 st019933 84.6 µM 1.5914679000953 0.0573013612473053 no 275 0.0557521569766253 338 6176082
SGTC_530 4358-1714 28 µM 1.5875737019337 0.0577477794587472 no 276 0.0561913843951376 443 1564641
SGTC_3198 9112019 49.47 µM 1.5764612692842 0.059036716808556 no 277 0.0574597689370773 366 45595555
SGTC_3006 9075424 71.4286 µM 1.57501902894237 0.0592056449058149 no 278 0.0576260261497458 374 7465181
SGTC_2357 9067248 200 µM 1.56832629073733 0.059994524261417 no 279 0.0584025016599385 361 9150235
SGTC_1494 4358-1428 177 µM 1.56827081903686 0.0600010969911775 no 280 0.0584089715186938 401 1564571
SGTC_1703 st026983 48.3 µM 1.56390197207577 0.0605205262064628 no 281 0.0589202956632391 394 1104023
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.56042391182238 0.0609365562010696 no 282 0.0593298688801147 314 61125 An anti-inflammatory.
SGTC_852 0418-0143 439 µM 1.54885665668331 0.0623362772886143 no 283 0.0607080911147424 483 5369229
SGTC_831 k061-1017 217 µM 1.54819754893319 0.0624167829423773 no 284 0.0607873706814498 569 1240153
SGTC_1830 st055982 50.3 µM 1.53891856734827 0.0635587729598686 no 285 0.061912088847331 416 455313 An antimicrobial agent.
SGTC_1706 st031321 9.9705 µM 1.537408849276 0.0637461064353853 no 286 0.0620966103504948 380 6103185
SGTC_5 0352-0601 109.883 µM 1.53604254395663 0.0639160145309162 no 287 0.0622639731934814 333 762456
SGTC_499 genistein 192 µM 1.53155477655344 0.0644765737450112 no 288 0.0628161697459318 321 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1932 st074806 40.9 µM 1.53121059786167 0.0645197217083698 no 289 0.0628586762024053 433 17251235
SGTC_2178 5812956 200 µM 1.5259283333634 0.0651847502817819 no 290 0.0635138567756818 378 5403383
SGTC_2051 5263410 176 µM 1.52456483041253 0.0653572738291222 no 291 0.0636838375550698 415 227584
SGTC_2243 6634756 200 µM 1.523979252063 0.0654314754852214 no 292 0.0637569470938987 342 885676
SGTC_227 fluconazole 33.516 µM 1.51730750995796 0.0662815061304996 no 293 0.0645945315021931 488 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1696 st025591 34.7925 µM 1.51674754207217 0.0663532375144499 no 294 0.0646652180060609 442 2787147
SGTC_110 0850-0284 111.64 µM 1.51171166226168 0.0670010330192686 no 295 0.0653036152428112 276 3906265
SGTC_2979 9012552 45.46 µM 1.51118203454408 0.0670694455185697 no 296 0.0653710391751527 338 17100905
SGTC_1077 5-fluorocytosine 377 nM 1.50901542291612 0.0673498713844031 no 297 0.0656474207411297 393 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2777 climbazole 1.536 µM 1.50810771053995 0.0674676261973899 no 298 0.065763481063036 454 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_171 k064-0041 9.68 µM 1.50348331373841 0.0680700070369725 no 299 0.0663572283310403 334 53325
SGTC_479 n-linoleoylglycine 10 µM 1.49562455245478 0.069103213752206 no 300 0.0673757606390971 372 6433346 An anti-infammatory.
SGTC_1656 st012921 11 µM 1.49485328851499 0.0692052610645503 no 301 0.0674763676988917 390 6732821
SGTC_654 1124-0271 80.9 µM 1.49238266058415 0.0695329360411272 no 302 0.0677994289939594 461 5403748
SGTC_2284 7945075 39.21 µM 1.48538982593299 0.0704668600489193 no 303 0.0687202946018165 483 1245402
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.48422629660364 0.0706231859778903 no 304 0.0688744478515334 435 115019
SGTC_2718 lomofungin 53.02 µM 1.47853822226733 0.0713912459418709 no 305 0.0696318871636532 410 5351222 A RNA synthesis inhibitor.
SGTC_1763 st044482 94.5 µM 1.4778613521213 0.0714830688534146 no 306 0.0697224463500764 449 88505
SGTC_1806 st050005 60.3 µM 1.47626775048185 0.0716996116651605 no 307 0.0699360140040877 431 5194765
SGTC_2124 5246320 200 µM 1.47276550368751 0.0721772740008069 no 308 0.0704071385123717 422 579342
SGTC_1717 st033143 58.0435 µM 1.47225956428626 0.0722464789173565 no 309 0.0704753990486342 488 674616
SGTC_888 0916-0002 6.97 µM 1.46691848744172 0.0729801632934058 no 310 0.071199115345672 430 2802138 YIL048W NEO1
SGTC_295 k015-0027 31 µM 1.45944337244528 0.0740165510470056 no 311 0.0722215578833354 425 3887424
SGTC_1278 0874-0585 172 µM 1.45875658680539 0.0741123316561949 no 312 0.0723160576470196 442 766306
SGTC_3123 9126162 49.47 µM 1.45739019499123 0.0743031731410364 no 313 0.0725043510461492 431 25239884
SGTC_944 3370-0224 231 µM 1.45202174696031 0.0750566095983578 no 314 0.0732477792637195 452 4580514
SGTC_3074 9116018 49.47 µM 1.4482536245667 0.0755889181578116 no 315 0.0737730661602942 407 17027303
SGTC_3005 9076496 71.4286 µM 1.44550625885479 0.0759788378723515 no 316 0.0741578681295721 410 21368410
SGTC_3143 9086658 49.47 µM 1.4447847758079 0.0760814877696214 no 317 0.0742591743269838 515 25236626
SGTC_191 3914-0123 66.505 µM 1.44320882902853 0.0763060746810885 no 318 0.0744808265735536 313 3144412
SGTC_2773 thioridazine 9.09 µM 1.44199762724306 0.0764790246672793 no 319 0.0746515214906925 459 5452 An antipsychotic.
SGTC_1473 k844-0725 134 µM 1.43960862525498 0.0768210291107925 no 320 0.0749890789946356 499 54682906
SGTC_2923 7992654 58.14 µM 1.43878262610461 0.076939547519623 no 321 0.0751060601922431 451 2985126
SGTC_2017 5132927 60.65 µM 1.4361763193904 0.0773144244165167 no 322 0.0754760877922556 470 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1951 sophoraflavanone G 9.2 µM 1.43566344818219 0.0773883561126305 no 323 0.0755490654458855 500 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1132 3456-3614 2.5 µM 1.42858851621423 0.0784137124572845 no 324 0.0765612683733119 569 3125502
SGTC_981 1488-1094 54.9 µM 1.42620558012338 0.0787613757626021 no 325 0.0769045046981645 405 3449522
SGTC_3145 9085516 49.47 µM 1.41881069258002 0.0798477049179292 no 326 0.0779771072523289 458 25236195
SGTC_2842 9000675 19.48 µM 1.41746718860247 0.0800462799630579 no 327 0.0781731904219582 451 2989072
SGTC_2973 9094665 17.96 µM 1.41722084464319 0.0800827310169532 no 328 0.0782091846360699 522 25237061 YIL048W NEO1
SGTC_597 k018-0003 82.8 µM 1.41602339080737 0.0802600947847858 no 329 0.0783843280581143 500 6786234
SGTC_79 0052-0007 94.094 µM 1.40776688409317 0.0814911162795041 no 330 0.0796000546683101 469 2801472
SGTC_2694 st077685 81.9 µM 1.40768172540448 0.0815038869711643 no 331 0.0796126677442614 473 2838096
SGTC_2179 6298986 200 µM 1.4073790862751 0.0815492839948871 no 332 0.0796575046528392 430 738374
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.40591805977436 0.0817687117870887 no 333 0.0798742289444622 495 688751
SGTC_1709 st033179 39.1045 µM 1.40474203243095 0.081945659349829 no 334 0.0800490010083938 495 573381
SGTC_2967 9089538 49.85 µM 1.40376698935452 0.0820925850558827 no 335 0.0801941234470435 520 728216
SGTC_594 1487-1584 10.8 µM 1.40260185194475 0.0822684155491218 no 336 0.0803677996338027 484 5013332
SGTC_50 0929-0078 56.389 µM 1.40256088591138 0.082274602876835 no 337 0.0803739112269749 478 1377751
SGTC_2334 9017922 200 µM 1.40126481522392 0.0824705366202733 no 338 0.0805674492766503 455 3163164
SGTC_398 bronopol 33.3 µM 1.40118623299086 0.0824824275904751 no 339 0.0805791950165574 475 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_743 1275-0778 158 µM 1.39944122320598 0.0827468130816601 no 340 0.0808403561959166 504 2849257 YMR203W TOM40
SGTC_1139 k015-0024 46.9 µM 1.39921929989464 0.0827804822183766 no 341 0.0808736153738173 445 2766652
SGTC_2218 6965428 192.983 µM 1.39759883506873 0.083026643853837 no 342 0.0811167841921992 480 675684
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.39738085988804 0.0830597980023546 no 343 0.0811495358551541 359 1241132 A phosphatase inhibitor.
SGTC_2555 cholic acid 100 µM 1.39238530405386 0.083822356422856 no 344 0.0819028761217236 470 6708657 Influences liver metabolism.
SGTC_3243 9134147 49.47 µM 1.39013577042586 0.0841674539260242 no 345 0.0822438264903356 464 24282180
SGTC_1326 1431-2094 10.8 µM 1.3854383820028 0.0848915100254873 no 346 0.0829592307723222 514 616278
SGTC_579 4491-1009 110 µM 1.38539219122023 0.0848986529911529 no 347 0.0829662887176248 618 1271041
SGTC_510 ag-490 170 µM 1.37902409904913 0.0858877367616115 no 348 0.0839436618822084 503 5328779
SGTC_71 0417-1750 47.813 µM 1.37890960902909 0.0859055977844662 no 349 0.083961312562622 531 6811472
SGTC_3015 9080845 49.47 µM 1.37524111327941 0.0864793742152857 no 350 0.0845283530309057 503 5296973
SGTC_3082 9117008 49.47 µM 1.36883724985746 0.0874878384058245 no 351 0.0855250770933013 501 41448529
SGTC_2961 9083290 32.55 µM 1.36775633806403 0.0876589199089217 no 352 0.0856941793613351 456 17741490
SGTC_2419 paclitaxel 166.5 µM 1.36759683513426 0.087684186382522 no 353 0.0857191538321428 568 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_871 0574-0004 149 µM 1.36428039516992 0.0882107673005946 no 354 0.0862396668510639 556 9551173
SGTC_1963 st076565 50.3 µM 1.36316226549212 0.0883888330549468 no 355 0.0864156883632747 505 4914280
SGTC_3244 9134489 49.47 µM 1.3619229242082 0.0885865149695478 no 356 0.0866111053472867 495 16584271
SGTC_312 4092-0653 6.84 µM 1.36172660313988 0.0886178594783452 no 357 0.0866420911631614 602 1148278
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.35620622188025 0.0895026257414926 no 358 0.08751678147337 551 1377
SGTC_315 k915-0449 187 µM 1.35616626974692 0.0895090528346393 no 359 0.0875231357175912 592 20970215 YNL149C PGA2
SGTC_894 0960-0238 55.9 µM 1.35381564489683 0.0898878019220863 no 360 0.0878976005441612 508 6741907 YDL195W SEC31
SGTC_1215 3852-0577 11.2 µM 1.35230816082354 0.0901313243737816 no 361 0.0881383774138074 569 2884876
SGTC_263 alizarin 107.927 µM 1.35056076739051 0.090414215275282 no 362 0.0884180877366219 588 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1565 sinapyl alcohol 95.1 µM 1.34697599817736 0.0909966273114568 no 363 0.0889939815002197 487 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1187 1391-0724 117 µM 1.34692863142928 0.0910043415005831 no 364 0.0890016096220786 541 6997986
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.34584828437981 0.0911804194773503 no 365 0.0891757250010741 487 688803
SGTC_2041 5107442 45.335 µM 1.34564544335992 0.0912135072233063 no 366 0.0892084443520664 518 793005
SGTC_1493 4348-0038 111 µM 1.34490267008941 0.0913347455608296 no 367 0.0893283339360372 560 800424
SGTC_1089 terbinafine 2.25 µM 1.34426286145978 0.0914392733478759 no 368 0.0894317002565875 496 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1657 st012939 43.4 µM 1.34389889014328 0.0914987761769862 no 369 0.0894905424889528 473 24207257
SGTC_3241 9133421 49.47 µM 1.34369601151089 0.0915319556743887 no 370 0.0895233538098133 425 17018221
SGTC_2735 sertaconazole 140 nM 1.33875882439229 0.0923421519658774 no 371 0.0903245996556983 441 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_949 1165-0505 146 µM 1.33756701530535 0.0925385215881113 no 372 0.0905188114305052 558 6244267
SGTC_2849 9019321 12.99 µM 1.33629277590194 0.0927488144617122 no 373 0.0907267984102642 480 16489627
SGTC_3210 9128157 49.47 µM 1.33568435353203 0.0928493494325462 no 374 0.0908262328057162 505 17590849
SGTC_2974 9094440 9.66 µM 1.32885459852392 0.0939834235816572 no 375 0.0919479725211744 572 25236134
SGTC_2313 7726885 200 µM 1.32613088538946 0.0944385333196779 no 376 0.0923981737075806 524 726423
SGTC_162 k030-0015 37.8 µM 1.32514157850563 0.0946042399196893 no 377 0.09256209893091 513 1809920 YMR134W ERG29
SGTC_843 0310-0051 143 µM 1.32137168833544 0.0952376523410362 no 378 0.093188730651144 528 2065037
SGTC_1015 4130-4525 82 µM 1.32112693358793 0.0952788834320528 no 379 0.0932295219288319 535 1363237
SGTC_1510 1123-0200 71.5 µM 1.31402795752415 0.0964804935921339 no 380 0.0944183980287898 622 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1181 1222-0449 220 µM 1.31342185030514 0.0965836000935965 no 381 0.094520419349276 529 658318
SGTC_1307 1187-1599 12.2 µM 1.31317145217311 0.0966262196012138 no 382 0.0945625906368762 533 1538471
SGTC_2234 tolnaftate 200 µM 1.31172684644382 0.0968723713429695 no 383 0.0948061575876258 448 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2240 6690706 185.951 µM 1.30981999657482 0.0971979911274681 no 384 0.0951283683814455 450 805876
SGTC_329 k048-0121 21.3 µM 1.30977168976425 0.0972062505715582 no 385 0.0951365415073876 509 6832902
SGTC_1626 st003712 1.76 µM 1.30408571901162 0.0981820329170219 no 386 0.0961021787610555 516 24207035
SGTC_338 4055-0136 114 µM 1.29982463004751 0.0989179779393983 no 387 0.0968305409133074 545 2900563
SGTC_1228 0124-0032 52.5 µM 1.29844888488065 0.0991564466011008 no 388 0.0970665650718685 570 X1228
SGTC_2453 5731132 22.18 µM 1.29818232563828 0.0992026999792127 no 389 0.0971123450245133 591 1362040
SGTC_2170 morpholine 200 µM 1.2976997918903 0.0992864693958835 no 390 0.097195257607833 536 121171 Reacts with secondary amines.
SGTC_578 3460-0051 92 µM 1.29507984411331 0.0997422036612589 no 391 0.09764634362442 608 2876744
SGTC_866 0495-0101 262 µM 1.28956272076838 0.100706889160065 no 392 0.0986012631193294 529 635694
SGTC_2440 5628896 157.78 µM 1.28705001893683 0.101148490923215 no 393 0.0990384273197353 534 5522048
SGTC_3053 9095903 49.47 µM 1.28661749504393 0.101224648186186 no 394 0.0991138213789302 530 17174018
SGTC_3055 9094636 49.47 µM 1.28552453374337 0.101417279082986 no 395 0.0993045245713959 520 25236176
SGTC_566 0958-0068 16.5 µM 1.28539933555057 0.101439361894039 no 396 0.0993263866441667 501 6815365
SGTC_3274 9138298 49.47 µM 1.28128462329226 0.102167076718797 no 397 0.100046855933707 582 17015756
SGTC_2703 st077852 53.4 µM 1.27751322655451 0.102837402880895 no 398 0.100710556928478 523 6281836
SGTC_138 0850-0259 40.9225 µM 1.2760871089779 0.103091711196259 no 399 0.100962364007683 697 6813004
SGTC_1892 st058411 7.36 µM 1.27392250919188 0.103478579509075 no 400 0.101345440130816 634 3934738
SGTC_757 1066-0008 322 µM 1.27317019898817 0.103613282666142 no 401 0.10147882651588 603 6842497
SGTC_344 k064-0035 6.43 µM 1.27279103807207 0.103681220647715 no 402 0.101546101088149 542 5088750
SGTC_1707 st032323 6.317 µM 1.27251960402748 0.103729875995285 no 403 0.101594281611801 599 3132057 YMR211W DML1
SGTC_1791 st048313 56.1 µM 1.27077541388787 0.104042922439306 no 404 0.101904278876852 510 1204976
SGTC_2247 cerulenin 830 nM 1.26866444282157 0.10442271408503 no 405 0.102280384709589 568 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1870 st057514 26.5 µM 1.26729556114061 0.10466953034277 no 406 0.102524813559888 580 5393161
SGTC_299 1273-0059 1.44 µM 1.26526899200334 0.105035706348115 no 407 0.102887459044326 553 2848077
SGTC_3276 9139060 49.47 µM 1.26323682597419 0.105403823823818 no 408 0.103252041001149 513 4870619
SGTC_2927 9011802 47.9 µM 1.26199562469961 0.105629120258416 no 409 0.103475180381043 552 43912568
SGTC_403 arphamenine a 50 µM 1.26126531655818 0.105761844617762 no 410 0.103606636396753 583 5487158 An arginine aminopeptidase inhibitor.
SGTC_839 0122-0028 230 µM 1.26049658013739 0.105901683030607 no 411 0.103745140403296 644 759448
SGTC_201 4262-0159 12.803 µM 1.25819447649879 0.106321250579896 no 412 0.104160716035924 500 1341029
SGTC_1678 st019265 80.2 µM 1.25549471566988 0.106814820561941 no 413 0.104649612599009 616 5367020
SGTC_3038 9091290 49.47 µM 1.25486330460647 0.106930493233073 no 414 0.104764193530735 583 25236843
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.25191018726894 0.107472695480342 no 415 0.105301296122729 664 688664
SGTC_1379 2144-0755 36.5 µM 1.25145232858639 0.107556936977605 no 416 0.105384747910166 627 5392327
SGTC_1990 st072050 59.8 µM 1.25046185958369 0.107739336322029 no 417 0.105565439785665 592 17233948
SGTC_614 0462-0418 107 µM 1.24815853833344 0.108164364704736 no 418 0.105986502162542 519 5188303
SGTC_971 1315-0384 26.7 µM 1.2466713302127 0.108439437442599 no 419 0.106259017638701 582 6769120
SGTC_526 4469-0568 170 µM 1.24281687787919 0.109154695376628 no 420 0.106967660780677 579 2901964
SGTC_2120 5538279 151.968 µM 1.24183787451074 0.10933690445755 no 421 0.107148192757121 582 2058197
SGTC_3088 9117578 49.47 µM 1.23907422807892 0.109852444487972 no 422 0.107659005100328 563 678341
SGTC_3066 9117245 49.47 µM 1.23865869359336 0.109930110338198 no 423 0.107735960961451 601 17176980
SGTC_524 r073-0010 27.8 µM 1.23499686597465 0.110616231564752 no 424 0.108415835266441 585 2772106
SGTC_345 1362-0200 395 µM 1.23428686925065 0.110749619023612 no 425 0.108548013539266 564 1419823
SGTC_2242 6630449 61.2675 µM 1.23234919356565 0.111114237572337 no 426 0.108909335456427 513 691249 YDR170C SEC7
SGTC_1567 st069303 68.4 µM 1.23190287908169 0.111198343643752 no 427 0.108992682906101 622 5581319
SGTC_3067 9117431 49.47 µM 1.23101683195824 0.111365450515522 no 428 0.109158284510737 544 17150885
SGTC_573 3702-0553 84.7 µM 1.23092520768266 0.111382740936255 no 429 0.109175419334928 589 1222756
SGTC_3312 9133330 71.43 µM 1.22927486317094 0.111694506565806 no 430 0.109484384277664 635 17617324
SGTC_1231 0242-0792 125 µM 1.22695630667663 0.112133557557492 no 431 0.10991950682349 584 3707635
SGTC_739 1486-1183 203 µM 1.22684540995406 0.112154588267895 no 432 0.109940349819102 619 4346692
SGTC_2232 chlorophetanol 41.5365 µM 1.22658011681667 0.112204910509964 no 433 0.109990223067752 740 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2332 7982454 138.89 µM 1.22654498329116 0.112211576037649 no 434 0.109996829141161 620 2981748
SGTC_2623 humulene 100 µM 1.22277433546359 0.11292858862605 no 435 0.110707470742229 524 6187145 An anti-inflammatory.
SGTC_1987 st072290 61.9 µM 1.22140035454919 0.113190671029917 no 436 0.110967236514305 625 54697379
SGTC_364 0083-0097 67.7 µM 1.22000967746557 0.113456379780523 no 437 0.111230603161277 610 5207356
SGTC_1819 st053448 58.6 µM 1.21924465439162 0.113602737889418 no 438 0.111375674013941 592 2857616
SGTC_721 1187-1332 279 µM 1.21922629446868 0.113606252016548 no 439 0.111379157258081 518 25730
SGTC_273 hydroxyurea 18.1 mM 1.21620892877774 0.114184835400264 no 440 0.111952671632753 680 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1349 flufenamic acid 69 µM 1.21564227631673 0.11429372532202 no 441 0.1120606110491 574 3371 A non-steroidal anti-inflammatory.
SGTC_1470 k295-0292 231 µM 1.2131330248754 0.114776800514899 no 442 0.112539482726898 626 5045612
SGTC_1610 st001799 48.1 µM 1.21094792942676 0.115198651742729 no 443 0.112957680846738 545 621897
SGTC_3289 9119912 71.43 µM 1.21081060120957 0.11522520088732 no 444 0.112984000632747 598 17014829
SGTC_360 0957-0399 1.01 µM 1.21066108315325 0.115254111593024 no 445 0.113012661652164 641 6752301 YPR165W RHO1
SGTC_1569 carminic acid 40.6 µM 1.21002317006776 0.115377515946251 no 446 0.113135001093508 638 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1366 1683-0113 21.9 µM 1.20998789614402 0.115384342429297 no 447 0.113141768708664 576 708623
SGTC_1891 st059073 26.2 µM 1.20934920936372 0.115507995698934 no 448 0.11326435640146 660 688754
SGTC_2146 5545642 200 µM 1.20880215230768 0.115613983789452 no 449 0.113369432262537 626 825326
SGTC_3182 9108849 49.47 µM 1.20756425140104 0.115854072556712 no 450 0.113607458421316 638 17133045
SGTC_2166 5933061 31.504 µM 1.20657032240845 0.116047099476939 no 451 0.11379883087263 611 2877375
SGTC_1817 st052116 64.4 µM 1.20399788740234 0.116547741374705 no 452 0.11429519754249 587 4361398
SGTC_2626 ethyl orsellinate 100 µM 1.20326069115434 0.116691494932145 no 453 0.114437727738661 588 75653 A natural product.
SGTC_1863 st057641 20.1 µM 1.20277218852967 0.116786822364448 no 454 0.114532244958494 669 3921635
SGTC_699 0375-0592 111 µM 1.20218052060997 0.116902355599342 no 455 0.114646797353048 638 762578
SGTC_3037 9091026 49.47 µM 1.20161102348954 0.117013636097041 no 456 0.114757134260051 727 25236398 YIL048W NEO1
SGTC_3227 9130768 49.47 µM 1.2007988333446 0.117172468967094 no 457 0.114914622268784 618 17720899
SGTC_1499 4480-0877 67.3 µM 1.19865705532158 0.117592049889212 no 458 0.11533066151409 575 2861909
SGTC_2945 9067681 61.76 µM 1.19863575118405 0.11759622877097 no 459 0.115334805201918 592 16456930
SGTC_2952 9073731 13.78 µM 1.19840287648147 0.117641914820845 no 460 0.115380106593293 669 16457353
SGTC_2216 7189485 200 µM 1.19212489991365 0.118878284237275 no 461 0.116606137461899 638 731273
SGTC_2833 9001315 45.46 µM 1.18776239410286 0.11974281196919 no 462 0.117463517055551 640 2989378
SGTC_1302 1159-0335 255 µM 1.18759251143429 0.119776567459327 no 463 0.117496994791363 605 649284
SGTC_2214 7179297 48.276 µM 1.18695600871633 0.119903099478349 no 464 0.117622486548665 624 769744
SGTC_2659 sanguinarine 24.21 µM 1.18515329371496 0.120261977138595 no 465 0.117978421447475 624 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1653 st012112 65 µM 1.18505480229542 0.12028160621544 no 466 0.117997889895358 600 720429
SGTC_441 propafenone 146 µM 1.18193523500722 0.120904495872809 no 467 0.118615699904227 561 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1074 carmofur 3.8 µM 1.18146163638404 0.120999258274337 no 468 0.118709692503727 704 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.17917639399123 0.121457247085501 no 469 0.119163971910084 724 368090
SGTC_2520 obtusaquinone 4.71 µM 1.17799153413401 0.121695185745015 no 470 0.119399990646155 630 5967872
SGTC_1076 itraconazole 331 nM 1.17453062725964 0.122392065801586 no 471 0.120091275884593 646 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1833 st055984 71 µM 1.16163910297321 0.125012499755908 no 472 0.122691045749333 647 676288
SGTC_2887 9044784 58.44 µM 1.16084638331954 0.125174903642586 no 473 0.122852188199029 688 6465546
SGTC_3280 9140961 49.47 µM 1.16078447500701 0.125187592951864 no 474 0.122864779040685 618 4901226
SGTC_1207 2099-0101 141 µM 1.16003242281093 0.125341812369324 no 475 0.123017802818832 706 5837381
SGTC_420 mitomycin C 81.9 mM 1.15998324976674 0.125351900646146 no 476 0.123027812952709 659 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2105 5350118 200 µM 1.15901262560915 0.125551148641276 no 477 0.123225519346904 661 2133313
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.15884224475439 0.12558614690892 no 478 0.123260247174742 663 16623 A steroid.
SGTC_2812 7970281 58.44 µM 1.150784332105 0.127249117695235 no 479 0.124910486049816 661 2233435
SGTC_2018 5133068 143 µM 1.15076368692278 0.127253397975967 no 480 0.124914733857632 624 785362
SGTC_3268 9137683 49.47 µM 1.1489527895989 0.127629233634893 no 481 0.12528772411037 628 1953228
SGTC_18 0111-0177 500 nM 1.14489190962315 0.128474836706395 no 482 0.126126967884466 771 721752
SGTC_3121 9125696 49.47 µM 1.14325230171323 0.128817354305468 no 483 0.126466926340779 643 1235365
SGTC_3229 9132204 49.47 µM 1.14169416984047 0.129143437923325 no 484 0.126790582532468 622 17682924
SGTC_2277 7947813 106.88 µM 1.13946158463936 0.129611666887048 no 485 0.12725534109867 645 1246798
SGTC_3279 9140807 49.47 µM 1.13709717347515 0.13010882377323 no 486 0.12774883270684 677 45595718
SGTC_395 anisomycin 6.25 µM 1.13703365396329 0.130122197988792 no 487 0.127762108598344 595 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_260 nsc-65238 3.989 µM 1.13697054577576 0.13013548654098 no 488 0.127775299470607 646 3246252
SGTC_1852 st056254 31.4 µM 1.13690073600578 0.130150187324625 no 489 0.127789892210131 654 442583
SGTC_1646 st011709 75.6 µM 1.13360746209769 0.130845002523662 no 490 0.128479620764281 637 5757843
SGTC_1957 st077035 62.4 µM 1.13347847394529 0.130872268527125 no 491 0.128506687951624 678 705593
SGTC_666 0272-0154 136 µM 1.13223212465189 0.131135928833076 no 492 0.128768428806933 707 6870312
SGTC_2733 amorolfine 100 µM 1.13206953256074 0.131170351588562 no 493 0.128802601376875 577 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_711 k292-0785 179 µM 1.12983508385708 0.13164404429156 no 494 0.129272860926121 676 4146315
SGTC_2101 5377231 179.231 µM 1.12948292962919 0.131718806898838 no 495 0.129347083323753 678 2844213
SGTC_3057 9095946 49.47 µM 1.12915762096954 0.131787896199608 no 496 0.129415673805808 683 24540043
SGTC_3016 9080866 49.47 µM 1.12913924183155 0.131791800320976 no 497 0.129419549751154 711 17066299
SGTC_3115 9123671 49.47 µM 1.12853743012549 0.131919682063553 no 498 0.129546509245357 702 3286988
SGTC_1446 4239-0190 62 µM 1.12789720324886 0.132055820755847 no 499 0.129681667577634 721 1340085
SGTC_474 dl-dihydrosphingosine 5 µM 1.12635034212469 0.132385147077453 no 500 0.130008628470401 688 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2458 5808907 16.39 µM 1.1244194806859 0.132797020587625 no 501 0.130417555787907 752 2731747
SGTC_2815 7968870 71.43 µM 1.12231071344866 0.133247850511312 no 502 0.130865176277811 714 2977326 YHR190W ERG9
SGTC_1977 st070720 65.3 µM 1.12134597110842 0.133454451915304 no 503 0.131070312267347 629 682188
SGTC_3314 9135860 59.4275 µM 1.11994619457165 0.133754608310569 no 504 0.131368345664874 717 25252478
SGTC_170 4197-0004 226 µM 1.11989005905591 0.133766655213092 no 505 0.131380307508102 620 218692
SGTC_766 1391-0721 126 µM 1.1156431512381 0.134680221667513 no 506 0.132287456755573 687 1020919 YIL115C NUP159
SGTC_793 0488-0545 106 µM 1.11306424670065 0.135237063189331 no 507 0.132840418842602 707 292548
SGTC_750 4073-0104 132 µM 1.11153148536767 0.135568766464392 no 508 0.13316982265753 581 22330957
SGTC_2085 5307070 144.047 µM 1.11066774695188 0.135755932554559 no 509 0.133355695028209 637 2840351
SGTC_2959 9079155 11 µM 1.11016297763355 0.135865394442756 no 510 0.133464401557606 627 16189457
SGTC_3039 9090270 49.47 µM 1.1084659079925 0.136233856040914 no 511 0.133830327339118 652 17173750
SGTC_1486 3970-0793 4.53 µM 1.10497970848189 0.136992910519734 no 512 0.134584190863832 707 2844330
SGTC_1648 st011736 69.8 µM 1.1019888140701 0.137646420743756 no 513 0.135233267339886 690 2855514
SGTC_2706 st078239 82.5 µM 1.10022418175355 0.138032989212357 no 514 0.135617228485019 708 15434492
SGTC_2913 7966556 36.57 µM 1.10009669996647 0.138060944607868 no 515 0.135644995768572 671 2976516
SGTC_3022 9087993 49.47 µM 1.09943436273617 0.138206250236505 no 516 0.135789324592552 683 17173644
SGTC_732 3970-1727 52.7 µM 1.09898237155923 0.138305469319723 no 517 0.135887877605997 708 1275699
SGTC_3090 9117696 49.47 µM 1.09586538025088 0.138991019200344 no 518 0.136568845703909 696 7923821
SGTC_1908 st060353 56.5 µM 1.09565454664493 0.139037473251037 no 519 0.136614990571505 765 4227716
SGTC_1318 1280-3875 124 µM 1.09225241916277 0.139788542878417 no 520 0.137361083898255 736 373245
SGTC_1856 st057054 55.7 µM 1.09154870237371 0.139944242303612 no 521 0.137515757026542 748 1266018
SGTC_1164 k060-0068 93.7 µM 1.08988569008465 0.140312656902698 no 522 0.137881750447032 760 5963676
SGTC_758 0868-0029 16 µM 1.08943387763354 0.140412862628904 no 523 0.137981299389632 718 762687
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.08895963485086 0.140518095348228 no 524 0.138085843184364 754 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3047 9092122 49.47 µM 1.08650790072136 0.141062979821771 no 525 0.138627173684876 680 17173831
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.08638514348507 0.141090299561783 no 526 0.138654315815618 747 23665772 A membrane-active detergent.
SGTC_1478 0453-0656 35.7 µM 1.08390301597654 0.141643469182312 no 527 0.139203901126281 720 5258496
SGTC_638 3970-0837 4.09 µM 1.08366885412783 0.141695730481165 no 528 0.139255824966203 724 4118451 YLR208W SEC13
SGTC_1807 st050092 58.9 µM 1.08161946437359 0.142153679910107 no 529 0.139710825984106 695 5008496
SGTC_983 1491-0821 12.2 µM 1.0784507242825 0.142863725203968 no 530 0.140416330360281 734 46495113
SGTC_1438 4092-1045 4 µM 1.07834594912027 0.142887243893105 no 531 0.140439699275335 741 1351342
SGTC_3290 9121031 71.43 µM 1.07713903279147 0.143158346869154 no 532 0.140709078713165 659 17014854
SGTC_2193 5925765 200 µM 1.07513214126359 0.143609912664856 no 533 0.141157785614201 670 877370
SGTC_1843 st055809 45.5 µM 1.07434756804248 0.143786708680376 no 534 0.141333466376201 697 16413835
SGTC_1260 0700-1617 7.75 µM 1.0735947480941 0.143956487401209 no 535 0.141502176252782 745 2853078
SGTC_37 0566-0070 1.56 µM 1.07342244258037 0.143995365381527 no 536 0.141540809771438 784 1626686
SGTC_2904 7225135 42.03 µM 1.07291410432915 0.144110105028679 no 537 0.141654828585648 768 4446116
SGTC_1550 gossypolone 36.6 µM 1.07269393671649 0.144159819323003 no 538 0.141704230855219 747 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2809 7964133 12.99 µM 1.07065318516378 0.144621175464531 no 539 0.14216269991551 738 1253665
SGTC_29 0299-0004 12.984 µM 1.06966895732469 0.144844036644632 no 540 0.142384171994537 623 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3347 9188721 44.724 µM 1.06693383892144 0.145464570074041 no 541 0.143000856513095 709 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.06567643275551 0.145750444744165 no 542 0.143284967350368 796 16486 A toxic proline analog.
SGTC_921 1561-0023 372 µM 1.06529671847964 0.145836847996838 no 543 0.143370838654384 751 24050882
SGTC_2731 amoxapine 43.43 µM 1.06227576014392 0.14652548755879 no 544 0.144055257669401 643 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2134 5324836 1.464 µM 1.05754812030709 0.147607545977532 no 545 0.145130752670535 667 699272
SGTC_880 0833-0487 87.2 µM 1.05678958963075 0.147781654885848 no 546 0.145303813252343 721 76075
SGTC_340 k038-0059 454 µM 1.05364038006439 0.148505977087153 no 547 0.146023797224292 765 23733424
SGTC_377 3970-0964 33.1 µM 1.05079299069314 0.149162920475463 no 548 0.146676837868673 842 16481235
SGTC_107 0358-0022 2.6945 µM 1.04918688112461 0.149534333379586 no 549 0.147046057680142 611 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1341 1486-1360 280 µM 1.04831649227368 0.149735868484301 no 550 0.147246406808538 759 3976547
SGTC_2469 5655019 90.81 µM 1.04705784340289 0.150027623997997 no 551 0.147536450442104 805 2788239
SGTC_472 calcifediol 10 µM 1.04691272606586 0.150061286631018 no 552 0.147569915940507 704 5283731 A vitamin D metabolite.
SGTC_3206 9114350 49.47 µM 1.04634866696025 0.15019217832881 no 553 0.147700041861388 702 17087243
SGTC_2865 9030313 51.95 µM 1.04554046622383 0.150379856459028 no 554 0.147886624065557 704 42562754
SGTC_2544 sphondin 68.51 µM 1.04477726765096 0.150557227701769 no 555 0.148062961815652 713 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1865 st057639 52.2 µM 1.0446509791482 0.150586591225423 no 556 0.14809215445677 754 688818
SGTC_2323 6148992 148.28 µM 1.04314188831677 0.150937767231138 no 557 0.148441291403665 684 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2549 cedrol 20.94 µM 1.04253101042659 0.151080077654542 no 558 0.148582777948759 706 6708665 A sedative which affects the nervous system.
SGTC_1051 3253-3903 78 µM 1.04214764945715 0.151169431200856 no 559 0.148671614915208 777 5509239
SGTC_2682 pyrogallin 40.03 µM 1.04133893661382 0.151358040798533 no 560 0.148859135912793 806 822798 An ATP competetive kinase inhibitor.
SGTC_2319 6033012 152.6 µM 1.04116246590166 0.151399218436619 no 561 0.1489000762117 702 847246
SGTC_454 lyso-paf C-16 6.67 µM 1.03844898767879 0.15203331875814 no 562 0.149530536447042 753 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2992 9074591 71.4286 µM 1.03787923280471 0.152166685916589 no 563 0.149663141519496 731 17741321
SGTC_225 nsc-122657 1.016 µM 1.0372220429759 0.152320616138719 no 564 0.149816193669736 633 275685
SGTC_2793 7325131 81.82 µM 1.03691149570299 0.152393389992407 no 565 0.149888552960759 733 4176441
SGTC_3356 9151811 4.48 µM 1.03658321505983 0.152470344582812 no 566 0.149965069566793 754 1859254 YPR165W RHO1
SGTC_106 0092-0003 11.579 µM 1.03637850376141 0.152518345460345 no 567 0.150012797454125 695 1072148
SGTC_3050 9093513 49.47 µM 1.03574113290841 0.152667860921114 no 568 0.150161463601067 777 25236664
SGTC_3273 9137859 49.47 µM 1.03455226641858 0.152947006838958 no 569 0.150439027931777 766 2377234
SGTC_1122 capsaicin 818.572 nM 1.03122056783952 0.153731091797378 no 570 0.151218698793983 791 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_64 000l-0018 272.079 µM 1.02994500182931 0.154031987836176 no 571 0.151517911981625 842 6811119
SGTC_1000 4048-0884 8.67 µM 1.02626640409748 0.154901921070926 no 572 0.152383014257643 749 13040088
SGTC_752 1896-0090 130 µM 1.02273431595572 0.155740254991892 no 573 0.153216740844696 791 772567
SGTC_1018 4259-0013 28.1 µM 1.02021069832302 0.156341059586281 no 574 0.153814272436959 754 6801262
SGTC_463 ikarugamyin 104 µM 1.01899453705142 0.156631138834738 no 575 0.15410278002827 751 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.01864576147509 0.156714394249604 no 576 0.154185585395949 757 140250 A respiratory chain inhibitor.
SGTC_297 0986-0032 24 µM 1.01800199864467 0.156868141875083 no 577 0.154338503129505 737 2847425
SGTC_2254 7938975 95.19 µM 1.01770438435463 0.156939253590938 no 578 0.154409231532125 853 2969277
SGTC_1979 st071809 45.3 µM 1.01352385548112 0.157940386687233 no 579 0.155405003727284 809 4976333
SGTC_3110 9122132 49.47 µM 1.0132939933037 0.157995554337374 no 580 0.155459877886174 815 918317
SGTC_314 1671-0008 2.74 µM 1.00702792872044 0.159504302150437 no 581 0.15696067656063 820 3913060
SGTC_2560 caryophyllene 100 µM 1.00633119246806 0.15967264355522 no 582 0.15712814024756 873 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_31 0508-1974 57.237 µM 1.0047124447374 0.160064204739066 no 583 0.157517666992479 779 6810525
SGTC_804 1595-0054 20.9 µM 1.00307693561741 0.160460457455566 no 584 0.157911871021893 751 761523 Stimulates phospholipase C.
SGTC_1402 3909-7673 35.9 µM 0.996976581995133 0.161944105606756 no 585 0.159387938508957 779 5328014
SGTC_1864 st057645 30.4 µM 0.994191932940031 0.162624312745006 no 586 0.160064717380056 791 688666
SGTC_1984 st072354 53.1 µM 0.993674694691757 0.16275086309307 no 587 0.160190633169687 811 5762938
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.993413464967445 0.16281480132729 no 588 0.160254251188026 837 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.99331178806724 0.162839692043718 no 589 0.160279017317027 792 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3155 9099265 49.47 µM 0.993247995731331 0.162855309803294 no 590 0.160294556923968 754 25236499
SGTC_1805 st050013 60.3 µM 0.991918499077989 0.163181021343261 no 591 0.160618642112125 783 4037144
SGTC_2600 tangeritin 87.95 µM 0.991668948985266 0.16324220542869 no 592 0.16067952144398 746 68077 A bioactive flavone.
SGTC_963 1269-2853 151 µM 0.988242186374885 0.164083878197741 no 593 0.161517025991126 773 3668223
SGTC_3087 9117406 49.47 µM 0.986929491196742 0.16440704346704 no 594 0.16183860274794 776 42546093
SGTC_1723 st034307 2.5525 µM 0.986316218808658 0.164558162965333 no 595 0.161988981680722 808 867466
SGTC_1267 0828-0272 9.49 µM 0.98272173610168 0.165445706684632 no 596 0.162872204938946 856 745334
SGTC_845 0330-0138 4.51 µM 0.982474549168848 0.165506855265734 no 597 0.162933057674568 813 9039800
SGTC_2540 epiandrosterone 100 µM 0.98094974287837 0.165884381800039 no 598 0.163308762859344 980 441302 A steroid.
SGTC_1559 coumarin 343 70.1 µM 0.980034978106919 0.166111135165611 no 599 0.163534426546905 780 108770 A hepatotoxic, DNA x-linker.
SGTC_177 1327-0068 8.361 µM 0.979658685742676 0.166204469224607 no 600 0.163627313014167 828 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2677 mitomycin C 100 µM 0.977283461728516 0.16679439188143 no 601 0.164214419182516 791 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1848 st056003 16.4 µM 0.974354106513509 0.167523799392146 no 602 0.164940374099187 879 146492
SGTC_1861 st057647 17.4 µM 0.973413167924539 0.167758527860964 no 603 0.165173998493093 829 688668
SGTC_194 1486-1323 56.904 µM 0.97143329978766 0.168253121086155 no 604 0.165666276449481 806 5178754
SGTC_2091 4-phenylthiadiazole 200 µM 0.971043780312247 0.168350537726183 no 605 0.165763238840389 839 270010
SGTC_261 5-fluorouridine 15.376 µM 0.970811925821744 0.168408540455113 no 606 0.165820971382207 837 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_166 k072-0058 166.424 µM 0.967327273444046 0.16928183898446 no 607 0.166690226850412 851 5846229
SGTC_2810 7959871 45.46 µM 0.96499455227301 0.16986807024818 no 608 0.167273770203093 886 2974535
SGTC_2456 5770359 74.46 µM 0.964784281319137 0.169920976880026 no 609 0.167326435283705 872 3118787
SGTC_423 5-fluorouracil 457 µM 0.964264245255492 0.170051869403836 no 610 0.16745673093397 801 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2071 5230951 39.92 µM 0.961126410039453 0.170843030077961 no 611 0.168244306016711 894 1799272
SGTC_1959 st077091 55.8 µM 0.960502685170665 0.171000573647881 no 612 0.168401140111234 866 821356 YKL052C ASK1
SGTC_1466 k213-0079 57.5 µM 0.960167536747271 0.171085265498028 no 613 0.168485451182858 855 3657981
SGTC_1399 3562-5772 25 µM 0.956540189964844 0.172003610322765 no 614 0.16939969482649 774 23847490
SGTC_2667 digitoxin 100 µM 0.956260997094817 0.172074424501154 no 615 0.169470194864733 809 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1608 st001473 40.5 µM 0.956128430219716 0.172108055135234 no 616 0.169503676414617 808 7292267
SGTC_1531 st059297 52.4 µM 0.953759319549134 0.172709777530546 no 617 0.170102742826564 869 7566702
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.952404976997089 0.173054364126715 no 618 0.17044581817001 820 5355888
SGTC_1172 0370-0043 85 µM 0.948914435257805 0.173944483115 no 619 0.171332066070457 854 376585
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.947752396865932 0.174241457942226 no 620 0.171627759824336 808 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2328 6201408 200 µM 0.947252431642718 0.17436932997876 no 621 0.171755081860611 816 2890418
SGTC_2621 lithochol-11-enic acid 100 µM 0.947004139066894 0.174432855900414 no 622 0.171818334905319 885 6708711
SGTC_992 3909-8734 162 µM 0.945451876322381 0.174830337174906 no 623 0.172214114198557 840 4288319
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.940954827064075 0.175985119439473 no 624 0.173364004506919 876 2724 A muscle relaxant with antifungal properties.
SGTC_1377 2944-0135 198 µM 0.939251679440695 0.176423723080836 no 625 0.173800770580298 896 1894137
SGTC_3223 9129970 49.47 µM 0.935046529695327 0.177509614088887 no 626 0.1748821603731 904 17248386
SGTC_684 1140-0066 328 µM 0.934622797089662 0.177619267556444 no 627 0.17499136311273 890 6813534
SGTC_2413 inermin 26.06 µM 0.933166685711821 0.177996405601226 no 628 0.175366956252744 897 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2563 tomatine 8.54 µM 0.932185341022274 0.178250861983148 no 629 0.175620374924977 901 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_779 1360-0071 233 µM 0.931848704590004 0.178338202432638 no 630 0.175707360048737 934 7566
SGTC_2942 9052777 62.25 µM 0.9304507285691 0.178701196280296 no 631 0.176068881843232 931 6469503
SGTC_481 bay k-8644 50 µM 0.929912276056257 0.17884113309377 no 632 0.17620825319415 812 2303 A calcium channel antagonist.
SGTC_2366 9070441 60.58 µM 0.928795965825655 0.179131467280252 no 633 0.176497417774265 891 6837235
SGTC_647 0140-0236 81 µM 0.926706125502085 0.179675797442241 no 634 0.177039568135338 976 990837
SGTC_1736 st036774 51 µM 0.926197671842688 0.179808388831345 no 635 0.177171631122516 910 1272247
SGTC_2082 5219693 150 µM 0.925496246391735 0.179991403058539 no 636 0.17735391765274 874 2834649
SGTC_2465 5809242 33.21 µM 0.919941877968612 0.181444763058852 no 637 0.178801566511001 910 2731748
SGTC_3175 9106517 49.47 µM 0.919872605789665 0.181462935125676 no 638 0.178819667927002 861 41468073
SGTC_2720 fluspirilene 36.88 µM 0.91973480395306 0.181499087862075 no 639 0.178855680161413 809 3396 An atypical antipsychotic.
SGTC_2766 oltipraz 83.91 µM 0.919196413017851 0.181640379595678 no 640 0.178996423495224 864 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_182 3448-4371 550.524 µM 0.918706881393188 0.181768908741877 no 641 0.179124454756936 954 3491403
SGTC_92 0063-0024 660.874 µM 0.91846302725941 0.181832955173595 no 642 0.179188253439547 984 3594437
SGTC_448 monastrol 171 µM 0.918039674372372 0.18194417910676 no 643 0.179299047678013 906 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_827 3253-0474 693 µM 0.917485298770499 0.182089889851076 no 644 0.179444196549065 939 5402065
SGTC_3217 9129673 49.47 µM 0.916374657718135 0.182382027468119 no 645 0.179735211259834 837 17248312
SGTC_1815 st051655 58.2 µM 0.913894824109069 0.183035366947137 no 646 0.180386056815204 889 5984156
SGTC_32 0928-0142 34.1 µM 0.913852114770799 0.183046631968717 no 647 0.180397279045948 886 2244242
SGTC_2996 9066192 71.4286 µM 0.912025374939254 0.183528857997712 no 648 0.180877679969153 870 6472854
SGTC_1265 0819-1001 68.8 µM 0.910647687798428 0.183893065551232 no 649 0.181240517697112 865 3106768
SGTC_2705 st078069 42.8 µM 0.909683599676122 0.184148200928035 no 650 0.181494697884389 837 1530061
SGTC_3301 9125354 19.7965 µM 0.908898057931204 0.184356248778334 no 651 0.181701969514817 817 41905162
SGTC_2819 7996655 46.38 µM 0.908117040752903 0.184563243231169 no 652 0.181908194064807 793 6456960
SGTC_77 0828-0286 12.516 µM 0.908019384492994 0.184589135415788 no 653 0.181933990112453 920 745345
SGTC_217 ketoconazole 989 nM 0.907684645882189 0.184677903793217 no 654 0.182022429177669 895 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_608 k048-0125 159 µM 0.90575088875754 0.185191230715566 no 655 0.182533860326809 928 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1525 8-methoxypsoralen 92.5 µM 0.899506743693001 0.186854817022478 no 656 0.184191402706016 983 4114 Related to psoralen; DNA damaging agent.
SGTC_44 0929-0055 61.211 µM 0.899003208616435 0.186989372317118 no 657 0.184325475793992 841 1379590
SGTC_2446 5162541 200 µM 0.895971500509998 0.187800775686152 no 658 0.185133992294552 874 1549321
SGTC_2723 salbutamol 83.58 µM 0.895757839217859 0.187858041691955 no 659 0.18519105591121 851 9884233 β2-adrenoceptor agonist
SGTC_204 PMA1.184 62.41 µM 0.895543468145359 0.187915508770548 no 660 0.185248320069415 972 2252213 YGL008C PMA1
SGTC_1927 st060202 13.8 µM 0.893076051826158 0.188577737494685 no 661 0.185908223363484 921 688887
SGTC_54 0159-0055 9 µM 0.891953064157948 0.188879611516179 no 662 0.186209045238299 917 3319099
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.89121953231024 0.189076955306251 no 663 0.18640570387441 900 6708514
SGTC_966 1300-0360 30.2 µM 0.890899913752262 0.189162982742167 no 664 0.186491433292022 881 70588
SGTC_147 4466-0538 29.23 µM 0.890461477115468 0.189281030046208 no 665 0.186609072304123 973 6742687 YHR072W ERG7
SGTC_1982 st072467 71.9 µM 0.890410176631438 0.189294845458648 no 666 0.186622839982153 951 3163533
SGTC_905 2-aminofluorene 215 µM 0.887776523490524 0.190004931871993 no 667 0.187330486784172 989 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.884386859937912 0.190921260142463 no 668 0.188243706888961 980 676296 Flavone; oxidizing agent.
SGTC_2883 9059145 45.46 µM 0.884173789973979 0.190978949792748 no 669 0.188301202361185 896 16476510
SGTC_2751 anetholtrithion 17.25 µM 0.88372880859813 0.191099464976877 no 670 0.188421312475882 905 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_914 3820-6779 408 µM 0.881857181749766 0.191606871755932 no 671 0.188927022283708 939 2893481
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.879186775592655 0.192332258447888 no 672 0.189650006782038 915 4330530
SGTC_1821 st053465 65.6 µM 0.877123073645323 0.192893989379701 no 673 0.190209896650642 890 675086
SGTC_1874 staurosporine 7.6 µM 0.875661389650931 0.193292459157263 no 674 0.190607070560611 970 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3078 9116413 49.47 µM 0.874350445797152 0.193650262616774 no 675 0.190963717535908 938 17177322
SGTC_962 1254-0300 21.5 µM 0.87346468784707 0.193892246117184 no 676 0.191204922720747 932 7340576
SGTC_1790 st045711 43.5 µM 0.872911492297738 0.194043469109684 no 677 0.191355660881651 940 585119
SGTC_2161 5662504 8.5105 µM 0.872405837738019 0.19418175901418 no 678 0.191493508469547 887 2859334
SGTC_2817 7995342 71.43 µM 0.871612729359896 0.194398784653694 no 679 0.191709841979837 876 18879975
SGTC_1238 0333-0287 48.8 µM 0.8678182210874 0.195439153096299 no 680 0.19274692672432 937 7226
SGTC_534 k292-0788 63.4 µM 0.867764443417103 0.195453921980791 no 681 0.192761649400455 1029 4146317
SGTC_980 1473-0395 201 µM 0.867334391568207 0.195572050886451 no 682 0.192879409117155 880 768876
SGTC_3202 9113761 49.47 µM 0.867038695108505 0.195653299492674 no 683 0.192960404218013 1004 4798415
SGTC_2267 7931562 200 µM 0.86511966521754 0.196181089797508 no 684 0.193486556103903 847 934880
SGTC_1037 k284-1091 78.7 µM 0.863167549513054 0.196718864553056 no 685 0.19402267629849 905 3334711
SGTC_2188 6126565 140.678 µM 0.860793396119513 0.197374105439107 no 686 0.194675921413062 922 874518
SGTC_2907 7721985 69.9 µM 0.859720700141989 0.197670590442512 no 687 0.194971510634076 965 3267881
SGTC_198 3454-2873 16.191 µM 0.859327405061692 0.197779361610747 no 688 0.195079954300772 945 710957
SGTC_1698 5-fluorocytosine 1.055 µM 0.854970083708207 0.198986857131928 no 689 0.196283854884729 995 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3258 9138477 49.47 µM 0.854773484836118 0.199041442906931 no 690 0.196338279909007 986 4970355
SGTC_3345 9148410 3.559 µM 0.852802421365505 0.199589208184809 no 691 0.196884440468412 959 4903596
SGTC_1362 1611-0397 101 µM 0.852478569728662 0.199679294354531 no 692 0.196974264186189 974 27816
SGTC_401 neomycin 50 µM 0.85198586803184 0.199816396646832 no 693 0.197110967843827 939 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1518 st038567 90.8 µM 0.851593625529835 0.199925584998639 no 694 0.197219839405564 957 77966
SGTC_1781 st038725 66.3 µM 0.84946820586269 0.200517860705485 no 695 0.197810407265057 1000 4270275 YIL048W NEO1
SGTC_1319 1306-0155 43.7 µM 0.84897212081264 0.200656252749642 no 696 0.197948402810457 995 3122360
SGTC_3041 9091929 49.47 µM 0.847890436454929 0.200958207244752 no 697 0.198249495552848 1049 25236887
SGTC_123 0083-0120 66.675 µM 0.847331062029216 0.201114464689635 no 698 0.198405308858883 958 16001701
SGTC_1325 1431-0015 227 µM 0.847290855407583 0.201125698942482 no 699 0.198416511227456 915 1103340
SGTC_393 acivicin 6.25 µM 0.846814911242143 0.201258712523886 no 700 0.198549147782446 894 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_324 1315-0088 19.6 µM 0.846725396279013 0.201283735437392 no 701 0.198574099868227 934 6787421
SGTC_725 1497-0963 19 µM 0.845454738294237 0.201639134869434 no 702 0.198928496739422 1013 3549977
SGTC_964 1287-0107 19.4 µM 0.844748374514095 0.201836865271642 no 703 0.199125672105254 995 51516812 YPR165W RHO1
SGTC_2657 nystatin 74.44 µM 0.844483540286558 0.201911029476462 no 704 0.199199628634797 1003 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2612 dictamnine 15.46 µM 0.843408904900649 0.202212137849894 no 705 0.199499896676101 929 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.842845696692542 0.20237005368198 no 706 0.19965737361362 976 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_488 nitrendipine 139 µM 0.842158463785779 0.202562844199958 no 707 0.199849630002174 1020 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1786 berberine 21.6 µM 0.841747151622481 0.202678282741496 no 708 0.199964749608991 921 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_529 4076-0302 30.3 µM 0.840502268610573 0.203027910095095 no 709 0.20031341506966 927 5816522
SGTC_631 k072-0230 41.5 µM 0.839972015343774 0.203176941864765 no 710 0.200462038677831 1006 5773147
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.838187360020772 0.203679012541899 no 711 0.200962742446241 1166 16725076
SGTC_1935 st074532 41.6 µM 0.834965478559116 0.204587283913141 no 712 0.201868572814566 1073 2829742
SGTC_1887 st057648 70.8 µM 0.834891945332493 0.204608041544046 no 713 0.201889275136334 993 688672
SGTC_1688 st021091 57.6 µM 0.829322728331196 0.206183809665317 no 714 0.203460906600634 1028 3656366
SGTC_1150 3909-7983 10.9 µM 0.827713226845953 0.206640542570553 no 715 0.203916463300335 990 23965914
SGTC_2642 cholecalciferol 100 µM 0.825334925826878 0.207316535660858 no 716 0.20459073424282 1002 9821465 A vitamin D precursor, similar to steriods.
SGTC_514 4466-0038 2.65 nM 0.822457759680197 0.208136068283033 no 717 0.205408208878883 1019 5722064
SGTC_1070 indatraline 8.81 µM 0.820645724742409 0.208653188502837 no 718 0.20592404728888 987 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2589 lobaric acid 100 µM 0.818149516641488 0.209366797548473 no 719 0.206635908704062 998 73157 A novel microtubule depolymerizer.
SGTC_2930 9013230 14.89 µM 0.815468610396568 0.210134804860201 no 720 0.20740206256425 1033 2995857
SGTC_947 3447-0010 211 µM 0.815395853746437 0.210155670716827 no 721 0.207422878460067 1047 748350
SGTC_2222 6885208 172.143 µM 0.814275796390963 0.210477045162822 no 722 0.207743486049198 979 609514
SGTC_2087 5276107 200 µM 0.813684861097255 0.21064671649809 no 723 0.207912754513281 1025 144405
SGTC_1469 k284-2957 126 µM 0.813398180060731 0.210729058225211 no 724 0.207994901222832 1043 23884841
SGTC_2780 5215298 71.43 µM 0.811413061933505 0.211299749982271 no 725 0.208564250258631 1049 2834131
SGTC_2892 9047358 58.44 µM 0.811294283223381 0.211333925767675 no 726 0.2085983461285 965 6466771
SGTC_2680 butyl paraben 22.24 µM 0.810818154072165 0.211470953253141 no 727 0.208735053752259 1043 7184 An antifungal and steroid mimetic.
SGTC_174 3553-0389 74.3 µM 0.810148074877617 0.211663886656843 no 728 0.208927538309266 973 738071
SGTC_2094 5332512 191.667 µM 0.80973395941262 0.211783172871911 no 729 0.20904654789885 1065 755774
SGTC_548 1436-0017 110 µM 0.808856028767568 0.212036191393028 no 730 0.209298981906959 1089 9677137
SGTC_2330 7979373 200 µM 0.80757793725025 0.212404851604357 no 731 0.209666795893695 999 1863007
SGTC_3196 9111891 49.47 µM 0.805320300100919 0.21305697197127 no 732 0.210317435141797 1059 18891510
SGTC_2127 5253358 187.912 µM 0.804117649932163 0.213404834772001 no 733 0.210664516080615 963 20612
SGTC_1507 4075-3230 155 µM 0.803677898334874 0.213532114161083 no 734 0.210791510820097 971 659771
SGTC_2322 7413319 38.22 µM 0.801181863861008 0.214255390909591 no 735 0.211513184491716 1052 1840400
SGTC_1752 st044819 83.042 µM 0.800463992024261 0.214463672461705 no 736 0.21172100896207 1019 441209 YML126C ERG13
SGTC_1035 k081-0041 55.2 µM 0.800434139012199 0.214472336489418 no 737 0.211729654020301 1064 731709
SGTC_193 1273-0060 1.558 µM 0.80018103334481 0.214545801726832 no 738 0.211802958550373 924 2847393 YHR072W ERG7
SGTC_3130 9127414 49.47 µM 0.798887101785658 0.214921600584773 no 739 0.212177939289294 1060 1494646
SGTC_104 0074-0074 590.992 µM 0.798778931337875 0.214953034028631 no 740 0.212209304601508 911 3943124
SGTC_2010 4012422 159 µM 0.797758719091841 0.215249630645745 no 741 0.212505260621266 1015 952393
SGTC_148 3253-0744 288.01 µM 0.79491799680717 0.21607673716659 no 742 0.213330602400184 1073 6893655
SGTC_1114 scopoletin 1.73284 µM 0.794138209639534 0.216304102100243 no 743 0.213557487795715 1060 5280460 A coumarin with genotoxic properties.
SGTC_131 0141-0277 33.849 µM 0.79296549225161 0.216646295530794 no 744 0.213898964023058 1019 1547771
SGTC_2293 7624732 200 µM 0.792924703146892 0.216658203232392 no 745 0.213910846865015 1048 894453
SGTC_596 1155-0152 116 µM 0.79239305848499 0.216813442679945 no 746 0.214065762820808 1054 280313
SGTC_3337 9144342 33.5465 µM 0.791840218753877 0.216974939245136 no 747 0.214226924039102 1051 17682949
SGTC_3102 9121669 49.47 µM 0.791445805056377 0.217090198586254 no 748 0.214341944782253 1053 41905072
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.790636424376039 0.217326834301811 no 749 0.214578092562617 1046 279621
SGTC_2804 7954240 19.48 µM 0.788374177347406 0.217989028764274 no 750 0.215238935326347 1052 828705
SGTC_3302 9125395 16.351 µM 0.788275284927254 0.218018002608601 no 751 0.21526785048909 1026 17599668
SGTC_58 0957-0393 9 µM 0.788112226028514 0.218065781018462 no 752 0.215315532216236 1077 6997992
SGTC_429 1112-0049 25.5 µM 0.787790124346613 0.218160178798518 no 753 0.215409739284735 969 2836170
SGTC_2656 pseudo-anisatin 100 µM 0.78769603048153 0.218187759168014 no 754 0.215437264010995 1064 6708809 A neurotoxin.
SGTC_527 4476-4215 268 µM 0.783997911833025 0.219273325365631 no 755 0.216520667792653 1030 4418754
SGTC_1011 4112-3381 17.4 µM 0.783134509827404 0.219527219431028 no 756 0.216774063887686 1055 2877139
SGTC_3189 9110682 49.47 µM 0.781169030258481 0.220105822385962 no 757 0.217351542991905 1065 17122418
SGTC_2428 5615643 7.78 µM 0.780534989016943 0.22029265952438 no 758 0.217538020481364 1036 2253075
SGTC_2020 4017018 200 µM 0.780509915550516 0.220300049957598 no 759 0.217545396721116 1080 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_599 1935-0052 86.5 µM 0.780499073858386 0.220303245602907 no 760 0.217548586229898 1106 9557311
SGTC_2684 capsaicin 100 µM 0.779738131650002 0.220527603672454 no 761 0.217772514628906 1051 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_585 0kpi-0023 191 µM 0.778392129353828 0.22092478274169 no 762 0.218168938656236 1039 64601
SGTC_460 trequinsin 123 µM 0.777485772272537 0.221192461617838 no 763 0.218436112702725 1109 5537 A vasodilator.
SGTC_1787 fluconazole 80 µM 0.775979144850165 0.221637831571651 no 764 0.218880649888907 1027 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2845 9003024 42.97 µM 0.775872135637484 0.221669483747444 no 765 0.218912243221283 1095 2990173
SGTC_455 paf C-16 10 µM 0.775372017796447 0.22181744747331 no 766 0.219059932472495 1048 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2224 6650123 117.647 µM 0.772006787381849 0.22281454268384 no 767 0.22005520375443 1045 2908370
SGTC_245 methotrexate 289.6 µM 0.771915997085874 0.222841478572639 no 768 0.220082090990501 1080 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1163 k060-0048 49.9 µM 0.771856896994745 0.222859013530241 no 769 0.220099594293213 1122 6809982
SGTC_762 1165-0429 115 µM 0.770254278917018 0.223334808839287 no 770 0.220574535933092 1085 5967793
SGTC_113 0099-0221 2.5 µM 0.769672120073771 0.223507786835634 no 771 0.220747206084242 1052 89219
SGTC_751 0833-0568 350 µM 0.769364271637584 0.223599289240372 no 772 0.220838546184908 1087 6954252
SGTC_1659 st012954 42.1 µM 0.768451160891123 0.223870820239888 no 773 0.22110959775201 1047 24207262
SGTC_150 3970-0969 77.2 µM 0.766399172258408 0.224481701675754 no 774 0.221719412590844 1083 6615640
SGTC_1949 st076024 69.1 µM 0.765668252988672 0.224699526178334 no 775 0.221936860788115 1111 2921930
SGTC_1591 genipin 88.4 µM 0.765285783703366 0.224813555309753 no 776 0.222050693767576 1032 442424 A DNA cross-linking agent.
SGTC_453 enantio-paf c16 10 µM 0.763707621729464 0.225284414287612 no 777 0.222520748885796 1106 13871343 A lipid and platelet activating factor
SGTC_1403 3909-7815 62.9 µM 0.763546580061355 0.225332493917546 no 778 0.222568746986016 1054 6615483
SGTC_1617 st002906 78 µM 0.762468234399313 0.225654587974406 no 779 0.22289029749842 1093 5150859
SGTC_3298 9116858 71.43 µM 0.761998906182545 0.225794854241372 no 780 0.223030328494871 1098 2506942
SGTC_1604 st002052 72.4 µM 0.758568837010308 0.22682148143241 no 781 0.224055260121912 1139 6254834 YHR062C RPP1
SGTC_6 0844-0013 19.835 µM 0.756843767475339 0.227338792094355 no 782 0.22457173395874 1237 1584900
SGTC_372 0155-0182 15.9 µM 0.756685236777089 0.227386365315184 no 783 0.224619230812152 1123 771486
SGTC_3091 9116372 49.47 µM 0.755910265396296 0.227619005925563 no 784 0.224851499401002 1073 17169793
SGTC_1893 st059353 36.1 µM 0.755617528516809 0.227706918205193 no 785 0.224939271714475 1076 3112488
SGTC_810 3825-7150 143 µM 0.751801837603328 0.228854561102769 no 786 0.226085118385464 1165 22330411 YGL099W LSG1
SGTC_2117 5521686 200 µM 0.750150961931362 0.229352098283799 no 787 0.22658189466212 1106 803312
SGTC_2013 4024628 200 µM 0.746887589875297 0.230337387648369 no 788 0.227565708835739 1106 5230760
SGTC_323 4013-0906 34.3 µM 0.746365576646916 0.230495215101506 no 789 0.227723303885004 1145 2910086
SGTC_2922 7999257 32.47 µM 0.744782224340753 0.230974301355276 no 790 0.228201691249836 1083 2988377
SGTC_2305 7443522 69.23 µM 0.744541912323656 0.231047062841906 no 791 0.22827434745644 1108 5415886
SGTC_3319 9138450 16.7555 µM 0.742619757738545 0.231629511510035 no 792 0.228855961565198 1075 2029690
SGTC_930 2810-3379 265 µM 0.742580796595728 0.231641325917967 no 793 0.228867759195534 1171 1015764
SGTC_982 1491-0518 27.5 µM 0.741563973498738 0.231949781670347 no 794 0.229175779027408 1071 3091256
SGTC_3098 9119039 49.47 µM 0.740557100300457 0.232255444345932 no 795 0.229481013746853 1163 17161528
SGTC_2587 piperic acid 92.2 µM 0.740059279045212 0.232406653761999 no 796 0.229632012932188 1088 5370536
SGTC_1472 k841-0093 193 µM 0.738026821265651 0.233024565115758 no 797 0.230249075325352 1201 X1472
SGTC_2185 6113692 200 µM 0.733881318332997 0.234287711670526 no 798 0.231510536937301 1128 874150
SGTC_1208 2323-2347 50.3 µM 0.733830218170992 0.234303305646239 no 799 0.231526110534452 1139 5412760
SGTC_2227 7312221 64.1025 µM 0.732880131950015 0.23459334322329 no 800 0.231815770957658 1161 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2813 7971799 71.43 µM 0.732786694562571 0.234621878043084 no 801 0.231844268863912 1119 2234054
SGTC_2236 dapsone 200 µM 0.732540472878087 0.234697080813021 no 802 0.231919374513896 1172 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_256 clotrimazole 625 nM 0.731949789675385 0.23487754578627 no 803 0.232099607400944 1113 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2729 fluphenazine 10.66 µM 0.731656982388285 0.234967032414516 no 804 0.232188979454802 1110 3372 An atypical antipsychotic.
SGTC_747 3448-8087 38.7 µM 0.731336072339727 0.23506512933306 no 805 0.232286951162627 1159 5168703
SGTC_794 k038-0031 316 µM 0.731052758375608 0.235151752547245 no 806 0.232373464148231 1176 6624242
SGTC_308 4092-1169 104 µM 0.730255774096373 0.235395524929766 no 807 0.232616928024575 1141 2268590 YDL196W YDL196W
SGTC_1339 1486-1321 22.7 µM 0.729850832549244 0.235519437208529 no 808 0.232740684444634 1134 3469382
SGTC_1513 0337-0559 19 µM 0.729738063750881 0.235553950912456 no 809 0.232775154851668 1091 775073
SGTC_2480 5767542 37.17 µM 0.728533616737372 0.235922754611482 no 810 0.233143499016768 1156 2867358
SGTC_2058 5236698 133 µM 0.728385290572025 0.235968194332318 no 811 0.23318888251425 1120 766665
SGTC_1925 st057770 10.1 µM 0.727894616600189 0.23611854666697 no 812 0.233339049432666 1104 5989122
SGTC_985 1493-0307 8.71 µM 0.72544744047727 0.236869197853064 no 813 0.234088789067769 1130 3278274
SGTC_2800 7887935 81.82 µM 0.723951982859932 0.237328562301834 no 814 0.234547607300288 1116 2961002
SGTC_2314 7727897 200 µM 0.7222846942353 0.237841284850185 no 815 0.235059730568187 1160 900724
SGTC_621 3584-0052 32.1 µM 0.721687246271934 0.238025159041779 no 816 0.235243392506963 1177 2273927
SGTC_1516 st013856 110 µM 0.721462448065201 0.238094364464274 no 817 0.235312518406751 1103 5281404 A mutagen and neurotoxin.
SGTC_169 k015-0017 16.025 µM 0.720404843861826 0.238420101939838 no 818 0.235637884252029 1165 1840002
SGTC_1436 4092-1007 8.32 µM 0.719488818657471 0.238702430792491 no 819 0.235919894556233 1138 2881121
SGTC_1775 st081588 35.1725 µM 0.71904400042883 0.238839594524518 no 820 0.23605690471883 1202 1426443 YGL099W LSG1
SGTC_219 mitoxanthrone 164.414 µM 0.717342070112611 0.239364797962099 no 821 0.236581527323792 1131 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1367 1812-0510 76.9 µM 0.716756405627985 0.239545675582758 no 822 0.236762207543874 1149 1142582 YDR527W RBA50
SGTC_2878 9043973 25.97 µM 0.716730752642246 0.239553600000173 no 823 0.236770123343822 1154 6465167
SGTC_2852 9023854 51.95 µM 0.716700263210239 0.239563018621579 no 824 0.236779531726246 1197 19798528
SGTC_802 4112-3352 742 µM 0.71643307233906 0.23964556634911 no 825 0.236861989872543 1188 704594
SGTC_1784 st039334 36.3 µM 0.715614400715449 0.239898588842343 no 826 0.237114739532627 1183 3496984
SGTC_1675 st018485 24.5 µM 0.715481739989026 0.239939603303133 no 827 0.237155710015842 1156 3323024
SGTC_1755 st041960 45.185 µM 0.715449105701273 0.239949693368947 no 828 0.237165789273233 1167 2257073
SGTC_956 1185-0240 191 µM 0.713792836621792 0.240462092398059 no 829 0.237677644924417 1161 1416193
SGTC_776 4476-4378 112 µM 0.712905710290192 0.240736787045512 no 830 0.23795205270644 1114 2892008
SGTC_630 4356-0227 183 µM 0.712806048380285 0.240767657570808 no 831 0.237982891186758 1178 779312
SGTC_257 daunorubicin 18.5 µM 0.712256338698004 0.240937970219478 no 832 0.238153027744968 1201 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.711336255104603 0.241223179755138 no 833 0.238437945053754 1258 688801
SGTC_1809 st050081 57.6 µM 0.709794259098547 0.241701582242667 no 834 0.238915864831517 1222 5036894
SGTC_178 4092-0806 87.505 µM 0.709037347438786 0.241936601524118 no 835 0.239150650397594 1155 2169044
SGTC_2261 9010538 184.68 µM 0.708861394719381 0.241991252180209 no 836 0.239205247028727 1116 6457250
SGTC_1632 st005650 90 µM 0.707340664476605 0.242463867654745 no 837 0.239677400368886 1162 2759605
SGTC_1503 4585-0012 61.3 µM 0.706467189692673 0.242735553738008 no 838 0.23994882490014 1170 2922052
SGTC_3154 9100113 49.47 µM 0.706269841072472 0.24279695997648 no 839 0.240010172437939 1178 25237525
SGTC_2792 7535235 81.82 µM 0.705018734313976 0.243186445071756 no 840 0.240399288768433 1154 1281891
SGTC_82 0054-0107 293.755 µM 0.704601487676938 0.243316414212055 no 841 0.240529136220988 1189 3104697
SGTC_929 2805-0021 398 µM 0.703227550345694 0.243744650401136 no 842 0.240956976293488 1177 3098024
SGTC_391 gliotoxin 8.33 µM 0.70229352690161 0.244036004010174 no 843 0.241248064634866 1211 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2272 7805186 180 µM 0.701678315658728 0.244228011842064 no 844 0.241439899521223 1171 2956062 YPR165W RHO1
SGTC_2787 5284540 71.43 µM 0.700848980395724 0.24448697676762 no 845 0.24169863354328 1187 736958
SGTC_2176 5809774 33.9695 µM 0.69780642353548 0.245438299024178 no 846 0.242649130695365 1188 2870539
SGTC_3267 9137951 49.47 µM 0.697502950424948 0.245533295533503 no 847 0.242744046804748 1183 16643986
SGTC_2387 9077560 195.08 µM 0.697070148571069 0.245668810121601 no 848 0.242879447325664 1186 5303272
SGTC_2734 clemastine 41.6 µM 0.696547542580181 0.245832496798467 no 849 0.243042997201359 1161 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_893 0958-0369 48.9 µM 0.696113827683879 0.245968386121939 no 850 0.243178773768834 1208 6819948
SGTC_1526 st051518 75 µM 0.696091264869245 0.245975456489875 no 851 0.243185838290225 1134 673993
SGTC_788 1182-0090 188 µM 0.696071040460905 0.245981794178754 no 852 0.243192170740116 1251 5715185
SGTC_1906 st060206 94.7 µM 0.69558732479036 0.246133401450529 no 853 0.243343653165267 1199 5133468
SGTC_2417 cerulenin 830 nM 0.694659389342586 0.246424377327584 no 854 0.243634391996572 1240 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2359 9039622 200 µM 0.693559209150767 0.246769603281248 no 855 0.243979341085261 1174 6463596
SGTC_1640 st009078 66.4 µM 0.692624031054974 0.247063256640721 no 856 0.244272762672419 1184 690618
SGTC_2132 5317594 122.667 µM 0.6920600540679 0.247240440221905 no 857 0.244449808065106 1177 794577
SGTC_2137 5261020 140 µM 0.689928247900444 0.247910799077789 no 858 0.245119655364347 1199 763655
SGTC_3024 9090631 49.47 µM 0.688449683276028 0.248376311441087 no 859 0.245584822955441 1166 25236383
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.686310297434166 0.249050701193624 no 860 0.246258728404427 1261 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2054 5233173 129 µM 0.686058787238939 0.249130047660309 no 861 0.246338019067409 1214 6889
SGTC_932 2857-0803 154 µM 0.686057279084103 0.249130523493732 no 862 0.246338494566929 1261 674898
SGTC_2159 5658611 73.75 µM 0.685623661548095 0.249267352914389 no 863 0.246475228340879 1234 793844
SGTC_311 1315-0136 58 µM 0.685331577129495 0.249359543619009 no 864 0.246567355017235 1246 6759207
SGTC_34 0469-0683 81.75 µM 0.684159095443161 0.249729796747512 no 865 0.246937354360049 1209 3690923
SGTC_1415 3966-0071 78.1 µM 0.68385059642637 0.249827264862291 no 866 0.247034756560893 1204 2893185
SGTC_1246 0422-0085 105 µM 0.68375677881003 0.249856909888683 no 867 0.247064381613371 1207 264295
SGTC_1464 k208-0027 110 µM 0.682650206627236 0.250206711750213 no 868 0.247413950389256 1233 X1464
SGTC_879 0831-1030 162 µM 0.680751287151499 0.250807589612741 no 869 0.248014439038172 1245 1549252
SGTC_2204 7233102 200 µM 0.680330361082518 0.250940887232868 no 870 0.24814765222672 1152 2172480
SGTC_2826 7992541 19.48 µM 0.680136845835272 0.251002181646361 no 871 0.248208908048527 1282 2985066
SGTC_1225 1216-0074 20.6 µM 0.680022215805703 0.251038493531307 no 872 0.248245197140172 1213 4241466
SGTC_86 0417-1630 471.922 µM 0.680006633147685 0.251043429936587 no 873 0.248250130450794 1259 3634867
SGTC_669 0108-0021 26.2 µM 0.679295877952235 0.251268643521072 no 874 0.24847520385754 1307 17201
SGTC_3051 9093778 49.47 µM 0.677306879849029 0.251899455139281 no 875 0.249105633350962 1235 17217378
SGTC_2836 9010338 19.48 µM 0.676984334058479 0.252001829386539 no 876 0.249207947041392 1141 2994051
SGTC_2003 4023581 200 µM 0.675894630405954 0.252347857599275 no 877 0.249553773579098 1245 16641307
SGTC_2598 perillyl alcohol 100 µM 0.674490759476595 0.252794016484122 no 878 0.249999679274407 1230 10819 An apoptosis inducer.
SGTC_3017 9080681 49.47 µM 0.673601585640884 0.253076816116106 no 879 0.250282322406507 1224 16451914
SGTC_1621 st003705 32.4 µM 0.672590833293492 0.253398485511658 no 880 0.250603817544558 1257 24207032
SGTC_1316 1272-0050 65.9 µM 0.672265338054684 0.253502119277837 no 881 0.250707396019085 1230 7340392
SGTC_2691 st077356 60.2 µM 0.671849745602954 0.253634471274345 no 882 0.250839678003522 1275 2839272
SGTC_2721 ifenprodil 61.44 µM 0.670629717443758 0.254023218121856 no 883 0.251228223108307 1240 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1899 st063254 59.6 µM 0.670111929135921 0.254188299386742 no 884 0.251393220460571 1184 3093813
SGTC_2399 5884133 200 µM 0.669661644537236 0.254331904841718 no 885 0.251536753770461 1244 722445
SGTC_2903 5923464 63.88 µM 0.667621646188714 0.254983036648297 no 886 0.252187568379723 1270 2876576
SGTC_3032 9089427 49.47 µM 0.667049434713974 0.255165833059622 no 887 0.252370278660214 1215 17173707
SGTC_1159 4092-0538 61.2 µM 0.666419805359222 0.255367051121414 no 888 0.252571403387889 1277 717301
SGTC_1919 st067113 52.3 µM 0.665819331794246 0.255559028756194 no 889 0.252763293415962 1241 1268243
SGTC_370 0180-0345 38.7 µM 0.665600428498334 0.255629033159607 no 890 0.25283326622362 1191 3989527
SGTC_2031 5180455 200 µM 0.664591244638798 0.255951895609147 no 891 0.253155985370455 1217 29949
SGTC_3208 9114115 49.47 µM 0.663873913643223 0.256181516533027 no 892 0.25338550679284 1217 650895
SGTC_2818 7996756 12.99 µM 0.663818377210182 0.256199298477463 no 893 0.253403281115541 1240 2241621
SGTC_1134 3477-0009 42.5 µM 0.663095964781286 0.256430662870787 no 894 0.25363454743689 1307 3973534
SGTC_2757 clomiphene 4.22 µM 0.662772403034121 0.256534324100194 no 895 0.253738165385733 1301 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1725 st036284 20.55 µM 0.662651215030405 0.256573155375416 no 896 0.253776980553227 1266 707914
SGTC_1835 st008666 49.2 µM 0.662187579983426 0.25672174239529 no 897 0.253925506465841 1198 690455
SGTC_812 4251-0442 148 µM 0.658167090715536 0.258012115895868 no 898 0.255215384457024 1249 5723007
SGTC_877 0771-0151 33.1 µM 0.658083404929633 0.258039010491664 no 899 0.255242269394559 1261 6166523
SGTC_1166 k206-0078 225 µM 0.654835079694968 0.259084066408147 no 900 0.256286971104159 1264 5404595
SGTC_1477 0139-0234 16 µM 0.654728813916739 0.259118291319105 no 901 0.256321185109234 1264 620880
SGTC_3211 9128781 49.47 µM 0.654373549631586 0.259232727893197 no 902 0.256435585536836 1257 17194361
SGTC_1842 st055362 61.2 µM 0.65245733962858 0.259850421318474 no 903 0.257053092327159 1252 676032
SGTC_2288 7946289 167.31 µM 0.6517923208958 0.260064968545967 no 904 0.25726757806994 1305 1246052
SGTC_1126 isoteolin 1.0172 µM 0.649262075791098 0.260882105993438 no 905 0.258084497073742 1248 133323
SGTC_290 2043-6722 48.1 µM 0.647802112622099 0.261354198200918 no 906 0.258556474408287 1267 773758 YLR208W SEC13
SGTC_2164 5685496 200 µM 0.647240707593573 0.261535850298038 no 907 0.258738084510201 1256 759046
SGTC_2605 digitonin 300 nM 0.647029874327059 0.261604085706285 no 908 0.258806304459809 1318 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2664 lyso-paf C-16 73.48 µM 0.646377645280964 0.261815235070718 no 909 0.259017407082338 1276 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1168 k815-0004 80.5 µM 0.646174441237369 0.261881037185624 no 910 0.25908319496839 1249 642433
SGTC_1401 3807-4679 7.6 µM 0.645948093220066 0.26195434383234 no 911 0.259156485952353 1279 3291456
SGTC_1445 4239-0156 97.7 µM 0.644263589552048 0.262500229247206 no 912 0.259702260986151 1350 4008346
SGTC_1766 st045414 44.774 µM 0.641959900095678 0.263247711491472 no 913 0.260449609933061 1311 253960
SGTC_1758 st042942 75.2445 µM 0.640492390683533 0.26372444311405 no 914 0.260926267285759 1249 669317
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.640340659172696 0.263773759358108 no 915 0.260975576323542 1380 6728940
SGTC_2592 piperlongumine 83.33 µM 0.640039076885399 0.263871794525516 no 916 0.261073597430861 1252 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2877 9040724 71.43 µM 0.639328103879239 0.264102983571737 no 917 0.261304754716611 1301 6463895
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.635318199752573 0.265408824546474 no 918 0.26261045302713 1326 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1100 amiodarone 5.07 µM 0.633594301792503 0.265971224052378 no 919 0.263172810256449 1321 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2045 5106652 78.05 µM 0.633508299830936 0.265999296887311 no 920 0.263200881282588 1269 673349
SGTC_2478 5763493 32.33 µM 0.63286159611348 0.266210442544204 no 921 0.263412014252463 1259 1365576 YLR208W SEC13
SGTC_1642 st009582 77.7 µM 0.632608815974067 0.266292997103275 no 922 0.263494564291351 1309 6739311
SGTC_2260 7964312 200 µM 0.630888813779693 0.266855070264474 no 923 0.264056613246992 1335 231951
SGTC_1210 3013-0140 750 nM 0.630187306174074 0.267084485313808 no 924 0.264286021704811 1329 905973
SGTC_335 4077-0256 27.6 µM 0.62927567292782 0.267382766771695 no 925 0.264584297438151 1306 3121989
SGTC_2223 6903751 107.57 µM 0.625426678495651 0.268643986569722 no 926 0.265845528492644 1282 5598863
SGTC_2868 9035608 32.47 µM 0.623978023151957 0.269119448025092 no 927 0.266321009032688 1296 6462614
SGTC_870 0573-2213 57.6 µM 0.623235566366634 0.269363292439395 no 928 0.266564866377748 1294 3916321
SGTC_2894 9048625 32.47 µM 0.623178692487312 0.269381976043444 no 929 0.266583551060359 1387 4092861
SGTC_1934 st074720 32.6 µM 0.622879058748292 0.269480419271012 no 930 0.266682000177104 1292 17250992
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.620041735642581 0.270413501025722 no 931 0.267615154942607 1333 66535 A nucleotide analog.
SGTC_2782 7736369 71.43 µM 0.618912858554044 0.270785191915532 no 932 0.267986883559641 1346 2950836 YOL077C BRX1
SGTC_644 1498-1197 63.3 µM 0.615331256418581 0.271966145791691 no 933 0.269167989861393 1366 6741615
SGTC_277 nystatin 15.5 µM 0.614614560962766 0.272202767442852 no 934 0.269404647992939 1287 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1636 st007707 68.9 µM 0.614550815168124 0.272223818484216 no 935 0.269425702375622 1345 403051
SGTC_889 0919-1524 82.7 µM 0.613499761614919 0.272571028914313 no 936 0.26977297017375 1302 3905452
SGTC_1439 4092-1168 46 µM 0.612993846691668 0.27273823379218 no 937 0.269940204195284 1324 2886240
SGTC_1996 st072960 66.8 µM 0.610885504370839 0.273435588405632 no 938 0.270637690972037 1306 1719405
SGTC_1059 3448-6867 171 µM 0.609789002933197 0.273798615473454 no 939 0.27100079360609 1305 3934407
SGTC_1700 st030840 7.9285 µM 0.609759554091793 0.273808368610934 no 940 0.271010548837536 1369 5499307
SGTC_1252 0493-0875 34.8 µM 0.609110418828755 0.274023398804604 no 941 0.271225626044755 1328 3960963
SGTC_1435 4092-0789 56.7 µM 0.608637136039159 0.274180229330528 no 942 0.271382491881372 1384 2248285
SGTC_1013 4112-3890 241 µM 0.606227147620529 0.274979508103662 no 943 0.272181963978728 1286 705171
SGTC_1368 1852-0141 284 µM 0.606102432412601 0.275020901438371 no 944 0.272223367933056 1320 2838987
SGTC_304 1310-0298 97 µM 0.605814737326473 0.275116399967392 no 945 0.272318891190557 1276 1550234
SGTC_3221 9128209 49.47 µM 0.605762000213106 0.275133907483172 no 946 0.272336403274244 1348 16460723
SGTC_834 0312-0008 75.7 µM 0.605368561474229 0.275264537460114 no 947 0.272467067671249 1347 6385573 YIL048W NEO1
SGTC_2379 9035213 200 µM 0.604774999478585 0.275461670341901 no 948 0.272664253621615 1425 646551
SGTC_23 0213-0011 39.996 µM 0.604431645201096 0.275575736325747 no 949 0.272778350930165 1369 627608
SGTC_821 1114-0266 29.2 µM 0.602337232106271 0.276272025424185 no 950 0.273474841049951 1327 3123235
SGTC_2951 9072950 58.06 µM 0.601456485205636 0.276565087956084 no 951 0.273767993221248 1326 16488155
SGTC_571 k831-0106 44.2 µM 0.600706032212936 0.276814916261131 no 952 0.274017900290682 1379 4783639
SGTC_2333 9017922 200 µM 0.600637534412461 0.276837724911474 no 953 0.274040716239613 1417 3163164
SGTC_1597 7-benzyloxygramine 47.5 µM 0.60035694753292 0.276931165372554 no 954 0.274134186788777 1334 260807
SGTC_744 1594-0068 283 µM 0.599448542213405 0.277233786513935 no 955 0.27443690744671 1359 668392
SGTC_842 0271-0008 11.1 µM 0.598864793454937 0.277428338694149 no 956 0.274631525275571 1396 1221709
SGTC_1062 mesoridazine 14.2 µM 0.598402613482129 0.277582421673112 no 957 0.274785661174273 1345 4078 A neuroleptic.
SGTC_2135 5326629 150.42 µM 0.598394066993474 0.277585271321458 no 958 0.274788511809041 1320 5020077
SGTC_572 0960-0087 17.7 µM 0.597473811790289 0.277892194824449 no 959 0.275095543193702 1308 6796365
SGTC_2489 cantharidin 73.42 µM 0.594126244461605 0.279010070669647 no 960 0.276213839352699 1317 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2373 9071805 200 µM 0.592745573017826 0.279471763842833 no 961 0.276675718624154 1384 10149009
SGTC_1777 st045864 34.765 µM 0.591742984089119 0.279807259508671 no 962 0.277011354093732 1342 4691462
SGTC_714 4296-0578 26.1 µM 0.590675984766436 0.280164523251553 no 963 0.277368770935706 1349 1589775
SGTC_2096 5468907 200 µM 0.590655612833531 0.280171346542462 no 964 0.277375597192976 1369 759785
SGTC_2571 chrysanthemic acid 100 µM 0.590359792725507 0.280270436377921 no 965 0.277474730285609 1292 2743 An insecticide.
SGTC_1759 st043059 70 µM 0.58974490507997 0.280476457456424 no 966 0.27768084237215 1339 669426
SGTC_2872 9044037 25.97 µM 0.589432173404382 0.280581267831483 no 967 0.277785699600797 1364 6465195
SGTC_854 0422-0053 192 µM 0.589160284481568 0.280672405371041 no 968 0.277876878185526 1341 3596728
SGTC_2556 citropten 84.59 µM 0.589063853855425 0.28070473248886 no 969 0.277909219930223 1332 2775 A potential DNA crosslinker.
SGTC_248 streptozotocin 5.23457 mM 0.58809242506889 0.281030491815494 no 970 0.278235128633717 1382 5300 DNA alkylating agent.
SGTC_2522 biochanin a 4.94 µM 0.587582758877428 0.281201476510876 no 971 0.278406193176304 1349 5280373 A possible chelator.
SGTC_49 0717-0965 32.132 µM 0.585990242032228 0.281736063428453 no 972 0.278941036132602 1431 5889349 YGL099W LSG1
SGTC_291 SEC14.278 35.5 µM 0.578868590352789 0.284132683541266 no 973 0.281338922655585 1407 1068044
SGTC_1588 farnesol 29.9 µM 0.578864539051131 0.284134049679423 no 974 0.281340289570677 1369 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_48 0382-0018 55 µM 0.578416292806981 0.284285222052568 no 975 0.281491548302951 1467 762596
SGTC_2228 7354201 200 µM 0.577227654189248 0.284686279987304 no 976 0.281892839051601 1400 753451
SGTC_1629 st005085 44.9 µM 0.576171059629711 0.28504301160061 no 977 0.282249782262962 1349 24207091
SGTC_67 0335-0847 266 µM 0.57497814888548 0.285446022789081 no 978 0.282653037606331 1603 4552207 YOR254C SEC63
SGTC_447 ml7 120 µM 0.572023948967571 0.28644523150645 no 979 0.283652874974593 1443 4216 Selective myosin light chain kinase inhibitor.
SGTC_1794 st048918 76.9 µM 0.571310786422695 0.286686695292444 no 980 0.283894495647845 1343 672303
SGTC_773 4358-1457 44.6 µM 0.569596269522976 0.287267593928343 no 981 0.284475779618409 1437 1186886
SGTC_1929 genistein trimethyl ether 50.5 µM 0.569483553036529 0.287305803114428 no 982 0.284514014541218 1424 136420
SGTC_470 aa-861 153 µM 0.568260957638331 0.287720398903082 no 983 0.284928892688813 1344 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3070 9117005 49.47 µM 0.567226199661915 0.288071517645426 no 984 0.285280254990676 1447 8779016
SGTC_1007 4101-0031 70 µM 0.565956344396006 0.288502686810111 no 985 0.285711728792945 1412 1146276
SGTC_252 miconazole 1.30953 nM 0.565832699433747 0.288544685706998 no 986 0.285753757690243 1365 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1710 st031758 61.5 µM 0.564726774753458 0.288920466888107 no 987 0.286129809873979 1456 5394341
SGTC_1162 k048-0130 20.1 µM 0.564493279806969 0.288999835366128 no 988 0.28620923618276 1358 6797406
SGTC_2671 danthron 100 µM 0.563798354031225 0.289236111860383 no 989 0.28644568605862 1366 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2420 aureobasidin a 50 nM 0.562356552648064 0.289726617337569 no 990 0.286936557306785 1537 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_200 k038-0079 37.545 µM 0.558745025592571 0.290956980900542 no 991 0.288167872905797 1414 3436683
SGTC_1413 3910-0535 34.4 µM 0.558732249433632 0.290961337772321 no 992 0.28817223323642 1456 2876951
SGTC_1880 MG-132 525 µM 0.558572841039614 0.291015701112728 no 993 0.288226639786798 1393 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1229 0139-0193 12.2 µM 0.557254358589526 0.291465527462937 no 994 0.288676827357487 1450 3090752
SGTC_1490 4089-0339 670 nM 0.556769382001596 0.291631068362777 no 995 0.288842502842534 1382 742542
SGTC_235 0330-0087 5 mM 0.555713971003575 0.291991471557955 no 996 0.289203202116491 1379 46494818 YHR062C RPP1
SGTC_3112 9123419 49.47 µM 0.555598859542957 0.292030792516587 no 997 0.289242555632467 1419 17015854
SGTC_1247 0448-0043 5.84 µM 0.555527063899612 0.292055318460249 no 998 0.28926710190868 1424 3089013 YGL099W LSG1
SGTC_896 0964-0007 44.5 µM 0.555204525590686 0.292165511853462 no 999 0.289377386894685 1387 6756758
SGTC_1714 st033236 13.627 µM 0.555038861910689 0.292222117434122 no 1000 0.289434039678544 1489 2916566
SGTC_1203 3992-3522 103 µM 0.554094865409633 0.292544768687063 no 1001 0.289756961965811 1632 5322312
SGTC_1214 0358-0031 63.7 µM 0.553670653765982 0.292689815085987 no 1002 0.289902131301905 1602 4301366
SGTC_43 0570-0105 72.5 µM 0.553106773835696 0.292882668542208 no 1003 0.290095149265963 1447 1114046 YDL195W SEC31
SGTC_2712 st079126 47.7 µM 0.552518285133296 0.293084001357774 no 1004 0.290296655101134 1357 3152970
SGTC_659 k018-0002 107 µM 0.552128517592624 0.293217383334604 no 1005 0.290430152421357 1414 6797879 YHR007C ERG11
SGTC_1348 1493-0373 93.8 µM 0.550683036110617 0.293712285704624 no 1006 0.290925487763178 1433 3010129
SGTC_1989 st071868 50.2 µM 0.550341649626976 0.293829225643749 no 1007 0.291042531158028 1453 16414057
SGTC_680 0417-1641 114 µM 0.549968136641205 0.293957194996675 no 1008 0.291170614227194 1386 2835990
SGTC_2956 9076196 2.52 µM 0.549886392766102 0.293985204717637 no 1009 0.291198648908255 1433 16423868
SGTC_617 3770-0098 35 µM 0.549534362754872 0.294105842682858 no 1010 0.29131939466422 1418 5962639
SGTC_2033 5192550 145 µM 0.549455458208267 0.294132885799833 no 1011 0.291346462008398 1381 182073
SGTC_1382 3002-2117 298 µM 0.547480285711599 0.294810214801387 no 1012 0.292024405448959 1493 1497314
SGTC_1085 doxorubicin 7.67 µM 0.547325888742533 0.294863191120038 no 1013 0.2920774304438 1480 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1458 k015-0034 6.33 µM 0.545732271281077 0.295410245516382 no 1014 0.292624992729439 1355 3598957
SGTC_3193 9111931 49.47 µM 0.545487074661534 0.295494457639502 no 1015 0.292709283883448 1446 17087244
SGTC_497 capsazepine 133 µM 0.545309004275775 0.295555622356594 no 1016 0.292770506143693 1354 2733484 A calcium channel blocker.
SGTC_2408 sulbentine 18.36 µM 0.545143530319079 0.295612465591859 no 1017 0.292827402963338 1511 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3282 9108498 15.4605 µM 0.543667857585013 0.296119607411643 no 1018 0.293335027401312 1395 16459645
SGTC_2772 vinpocetine 57.06 µM 0.543190293618848 0.296283816433464 no 1019 0.293499394443875 1454 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2526 patulin 37.61 µM 0.541385729583842 0.296904687377981 no 1020 0.294120870594915 1465 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_665 3914-0008 307 µM 0.540480665178296 0.297216304149457 no 1021 0.294432795724007 1373 1069549
SGTC_1780 st038448 24.544 µM 0.539809605479987 0.297447448762619 no 1022 0.294664171048206 1515 728868 YDL195W SEC31
SGTC_247 mechlorethamine 29.705 µM 0.536083032386831 0.298732547414771 no 1023 0.295950583120753 1407 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3007 9078383 71.4286 µM 0.53457731274222 0.299252505686258 no 1024 0.296471087569272 1435 6496995
SGTC_2444 5485484 36.41 µM 0.534568797204234 0.299255447457073 no 1025 0.296474032454323 1539 6790631
SGTC_2300 7976697 71.57 µM 0.533889757497839 0.299490070185137 no 1026 0.296708904433508 1365 2236109
SGTC_313 3474-0040 5.03 µM 0.533637007584459 0.299577421971252 no 1027 0.296796349458124 1385 1043375 YIL048W NEO1
SGTC_457 grayanotoxin iii 135 µM 0.531300714936143 0.300385403799149 no 1028 0.29760520502918 1399 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2925 9010536 32.5 µM 0.530954721854782 0.300505145465497 no 1029 0.297725077917262 1515 2994177
SGTC_564 3555-0129 330 µM 0.530050318978303 0.300818243981717 no 1030 0.298038521661941 1387 563260
SGTC_365 0121-0052 13.6 µM 0.530019742675999 0.300828831874168 no 1031 0.298049121282182 1475 3101739
SGTC_3109 9122853 49.47 µM 0.528865993266652 0.301228472377954 no 1032 0.298449207002735 1521 1234709
SGTC_1423 4048-0112 5.59 µM 0.528481272210894 0.301361786798064 no 1033 0.298582671045445 1502 X1423
SGTC_187 1488-2104 32.728 µM 0.528007848732611 0.301525875029547 no 1034 0.298746944195771 1509 2852859
SGTC_2512 diallyl trisulfide 49.23 µM 0.526689086175708 0.301983168973733 no 1035 0.299204757894681 1404 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.524813968724659 0.302633920260794 no 1036 0.299856259983991 1394 390807
SGTC_1942 st076330 65.2 µM 0.522295167630975 0.303509046610741 no 1037 0.300732416628427 1464 24208414
SGTC_25 0118-0223 35.662 µM 0.522261121377566 0.303520883299965 no 1038 0.300744267414862 1497 5333628
SGTC_2259 7964009 200 µM 0.518841425276957 0.304710840425754 no 1039 0.301935663720251 1486 313134
SGTC_1663 st014140 55.4 µM 0.518486617006722 0.304834422316026 no 1040 0.302059397564238 1527 4207120
SGTC_3063 1327-0034 4 µM 0.518028686235481 0.304993955321451 no 1041 0.302219127419213 1380 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3135 9127742 49.47 µM 0.517589422495061 0.305147019979836 no 1042 0.302372381677451 1433 3643468
SGTC_1867 st057372 64 µM 0.517198323834257 0.305283329852349 no 1043 0.302508860998597 1438 688837
SGTC_2994 9053520 71.4286 µM 0.515201145655252 0.305979828450189 no 1044 0.303206234274978 1535 4647384
SGTC_1304 1165-0502 251 µM 0.514398609959126 0.306259903731853 no 1045 0.303486665448774 1483 767425
SGTC_2889 9059656 51.95 µM 0.512780498114028 0.306824949518045 no 1046 0.304052436499427 1526 3949838
SGTC_378 3970-0959 8.33 µM 0.51268002017922 0.306860051641599 no 1047 0.304087583998177 1473 6615653
SGTC_2210 7115885 190.385 µM 0.51063276947549 0.307575647144035 no 1048 0.304804112665429 1455 2927039
SGTC_2950 9072895 21.46 µM 0.507342966977404 0.308727098237491 no 1049 0.30595709778996 1416 17332245
SGTC_89 0302-0250 142.109 µM 0.507287067954184 0.308746679539048 no 1050 0.305976705524535 1535 4203518 YLR208W SEC13
SGTC_1650 st011916 45.8 µM 0.504795362677456 0.309620069912688 no 1051 0.306851286620014 1530 242528
SGTC_2384 9036245 200 µM 0.502248509044845 0.310513903164857 no 1052 0.307746362146497 1544 6462766
SGTC_2496 diffractaic acid 79.83 µM 0.500560298718888 0.311107008140302 no 1053 0.308340304613552 1604 94870 An apoptosis inducer which activates caspases.
SGTC_2029 5175081 200 µM 0.500475166052119 0.31113693010946 no 1054 0.308370269111872 1463 1380876
SGTC_546 peri-Naphthalide 147 µM 0.499996911729373 0.311305047550235 no 1055 0.308538625999834 1552 223824 A penicillin ester.
SGTC_137 0438-0332 85.389 µM 0.499298031387597 0.311550790918553 no 1056 0.308784720890585 1447 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1744 st037937 38.9 µM 0.49848578675459 0.311836501438532 no 1057 0.309070842361647 1542 1016152
SGTC_1459 k035-0031 35.7 µM 0.497703022197109 0.312111949407565 no 1058 0.309346688816418 1382 3877128 YMR208W ERG12
SGTC_2514 salinomycin 42.74 µM 0.497408076570554 0.312215765445585 no 1059 0.309450655627531 1607 23682228 A polyether potassium ionophore.
SGTC_246 cycloheximide 667 µM 0.496812062458611 0.31242559817557 no 1060 0.309660794075511 1428 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_702 1488-0190 94 µM 0.495955573012736 0.3127272403693 no 1061 0.309962878035458 1571 949357
SGTC_2788 5282734 71.43 µM 0.494048535217824 0.313399319720199 no 1062 0.310635951349613 1628 743706
SGTC_835 0312-0010 67.2 µM 0.49396392907048 0.313429151048314 no 1063 0.310665827105616 1461 1626196
SGTC_1940 st075990 51.1 µM 0.493773684160663 0.3134962340635 no 1064 0.310733010123648 1574 1084979
SGTC_2936 9038235 15.59 µM 0.493227382726777 0.313688901875002 no 1065 0.310925965889325 1465 4749415
SGTC_2583 asiatic acid 100 µM 0.492267360409409 0.314027602538479 no 1066 0.311265175413909 1500 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2484 5809818 12.04 µM 0.489982105596892 0.314834481988725 no 1067 0.31207328070633 1499 2870548
SGTC_3228 9131799 49.47 µM 0.48914347772677 0.315130807454896 no 1068 0.312370061159139 1532 17015818
SGTC_1096 rimcazole 32.2 µM 0.487593748499827 0.315678710501301 no 1069 0.312918812244251 1481 18528119 A dopamine reuptake inhibitor.
SGTC_1343 1487-0095 224 µM 0.487180165393034 0.315825000389545 no 1070 0.313065330043332 1529 4560101 YGL055W OLE1
SGTC_1767 st044992 70.3 µM 0.48518817837001 0.31652999672796 no 1071 0.313771433481414 1442 9600693
SGTC_2482 5981709 142.65 µM 0.484576699018113 0.316746543078858 no 1072 0.313988322796231 1545 877755
SGTC_288 1315-0019 35.1 µM 0.483424844207496 0.317154625940043 no 1073 0.314397055682085 1510 6811474
SGTC_342 k048-0088 23.3 µM 0.482678869334042 0.317419031056569 no 1074 0.314661884545463 1467 6820570
SGTC_2654 protoveratrine a 100 µM 0.482432567100592 0.317506351479268 no 1075 0.314749345357215 1498 5702278 A heart drug and vasodilator.
SGTC_3239 9133757 49.47 µM 0.48201672450044 0.317653801330579 no 1076 0.314897032772362 1558 17036923
SGTC_3113 9123498 49.47 µM 0.481518842930927 0.317830378686067 no 1077 0.315073895449605 1550 8897275
SGTC_1812 st052057 4.327 µM 0.480632865577306 0.318144699512763 no 1078 0.315388726404269 1464 3645418
SGTC_254 nsc-64875 3.808 µM 0.480552606892295 0.318173179600551 no 1079 0.315417252855155 1624 56993
SGTC_2184 6075246 200 µM 0.480404667378901 0.318225679294733 no 1080 0.315469838075733 1536 2267320
SGTC_2023 5144124 124 µM 0.479130941739857 0.318677840724862 no 1081 0.315922739411799 1490 2830192
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.478982620213846 0.318730511136129 no 1082 0.31597549639554 1564 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2784 7567673 72.73 µM 0.478294936231821 0.318974762219211 no 1083 0.316220149991388 1500 3471247
SGTC_2799 7812892 81.82 µM 0.477236447754986 0.319350868999184 no 1084 0.316596879937232 1603 20205235
SGTC_609 0986-0026 86.3 µM 0.476168334672371 0.319730584150516 no 1085 0.316977228362677 1561 2848610
SGTC_1928 4'-methoxychalcone 40.3 µM 0.475520143162888 0.319961108996806 no 1086 0.31720813969069 1684 641818
SGTC_2871 9038510 12.99 µM 0.475224436295233 0.320066298211376 no 1087 0.317313505765004 1647 4945164
SGTC_1449 4112-4002 201 µM 0.474515653326702 0.320318486248235 no 1088 0.317566119110554 1447 2059539
SGTC_535 2293-4129 48.2 µM 0.474359249843158 0.320374146465527 no 1089 0.317621873443004 1627 396118 YIL048W NEO1
SGTC_777 1315-0167 517 µM 0.4700971783879 0.321892466538724 no 1090 0.31914279499415 1480 4221767
SGTC_730 1436-0052 41.2 µM 0.470041868262259 0.321912189844155 no 1091 0.319162552526114 1526 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_396 dithiazanine 1.25 µM 0.466525463317399 0.323167149594582 no 1092 0.320419712784162 1473 10578 An antihelmenthic.
SGTC_2662 daunorubicin 22.37 µM 0.465326662669996 0.323595447507826 no 1093 0.320848771916614 1484 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2564 betulinic acid 100 µM 0.46473632518272 0.32380644451254 no 1094 0.32106014583622 1728 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1645 Cervolide 78 µM 0.463878794372763 0.324113041990924 no 1095 0.321367293246492 1521 23173 A fragrance.
SGTC_3046 9092212 49.47 µM 0.463740203348153 0.324162604371864 no 1096 0.321416944774605 1558 25236637
SGTC_740 k014-0057 261 µM 0.461431423596854 0.324988718975213 no 1097 0.322244555489354 1652 4012779
SGTC_2279 7948423 32.93 µM 0.458965880906457 0.325871876629744 no 1098 0.323129333774183 1679 1247112
SGTC_1235 benzylparaben 21.5 µM 0.458811166119454 0.325927328141307 no 1099 0.323184887771118 1528 7180
SGTC_1381 2324-0066 62.1 µM 0.458463294642855 0.326052023232957 no 1100 0.323309813638411 1573 10885928
SGTC_2713 st079149 53.4 µM 0.458440293486035 0.326060268720517 no 1101 0.323318074401395 1577 3103253
SGTC_2474 5321570 43.32 µM 0.456250271833325 0.326845739868937 no 1102 0.324105009410781 1618 2841384
SGTC_3222 9128301 49.47 µM 0.456229015791262 0.326853367309604 no 1103 0.324112651150948 1541 4911358
SGTC_483 fpl-64176 144 µM 0.454969621664007 0.327305412744629 no 1104 0.324565546951301 1551 3423
SGTC_1054 3429-0080 167 µM 0.453750124181532 0.327743379224073 no 1105 0.325004342736833 1613 1162877
SGTC_2622 2-methoxyxanthone 59.94 µM 0.452863911383832 0.328061799673276 no 1106 0.325323369473848 1694 71034 A hepatoprotective.
SGTC_1092 toremifene 6.32 µM 0.45136840066117 0.328599427120381 no 1107 0.325862026973008 1546 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2145 5634607 200 µM 0.450415646273019 0.328942122010631 no 1108 0.326205382617282 1511 308662
SGTC_1093 fluphenazine 7.97 µM 0.448970990548323 0.329462022549968 no 1109 0.326726291780886 1586 6602611 An atypical antipsychotic.
SGTC_671 0560-0003 407 µM 0.448678732553287 0.329567240064863 no 1110 0.326831714329041 1597 3238678
SGTC_3311 9131146 2.8755 µM 0.448269310651751 0.329714661134952 no 1111 0.326979423186302 1546 4900406 YPR165W RHO1
SGTC_1314 1222-0010 41.1 µM 0.44781764448856 0.329877323846972 no 1112 0.327142404134384 1575 3526027
SGTC_650 1328-0195 38 µM 0.44760257000848 0.329954791918889 no 1113 0.327220024022329 1595 2780821
SGTC_317 4495-0002 170 µM 0.445693423524608 0.330642770268823 no 1114 0.327909357862901 1533 15991618
SGTC_2991 9074669 71.4286 µM 0.445635302645715 0.330663723650096 no 1115 0.327930352731702 1651 17333109
SGTC_172 1112-0046 2.638 µM 0.444944900498024 0.330912663757215 no 1116 0.328179786660117 1573 2802135 YIL048W NEO1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.444055402060789 0.331233502767583 no 1117 0.328501264623534 1642 688798
SGTC_69 0096-0274 206.684 µM 0.441840395054231 0.332032986273656 no 1118 0.329302352562698 1641 6741392
SGTC_130 0136-0219 337.655 µM 0.437184225763457 0.333716073386904 no 1119 0.33098887431264 1639 234244
SGTC_2722 naftopidil 47.16 µM 0.436477792659863 0.333971724691571 no 1120 0.331245054049504 1616 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1156 4092-0367 4.88 µM 0.435675679775736 0.334262095016075 no 1121 0.331536026716929 1592 1357585
SGTC_1437 4092-1038 11.6 µM 0.435210087956018 0.33443068794294 no 1122 0.331704970418707 1542 3977136
SGTC_1727 st034309 9.9045 µM 0.433977201046305 0.334877283166023 no 1123 0.332152498540101 1697 870305
SGTC_3251 9135047 49.47 µM 0.433290501542886 0.335126131345181 no 1124 0.332401868876131 1676 17682963
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.433048965054078 0.335213677259372 no 1125 0.332489598884361 1730 551469
SGTC_2268 7933382 153.85 µM 0.432607484684634 0.335373716802911 no 1126 0.33264997549724 1549 935025 YOR257W CDC31
SGTC_517 1365-0151 113 µM 0.432512142735141 0.335408282812082 no 1127 0.332684614398613 1607 768657
SGTC_3146 9095609 49.47 µM 0.431917765859645 0.33562380421887 no 1128 0.332900591018416 1643 17173999
SGTC_3293 9120939 62.045 µM 0.430980485974546 0.335963772333144 no 1129 0.333241279734366 1635 934087
SGTC_1034 k072-0165 12.7 µM 0.43096471493956 0.335969493917763 no 1130 0.333247013473114 1697 5835461
SGTC_569 4130-2812 160 µM 0.427779110654601 0.33712597916744 no 1131 0.334405973415563 1611 743552
SGTC_1384 3089-0840 101 µM 0.42733173880288 0.337288514369381 no 1132 0.334568859285513 1691 1069836
SGTC_1988 st071872 53.4 µM 0.424701031260031 0.338244893398375 no 1133 0.335527315966909 1643 16414116
SGTC_2937 9044753 11.33 µM 0.423832288698464 0.33856094965153 no 1134 0.335844064179506 1540 6465530 YGL099W LSG1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.423465883733021 0.338694285144076 no 1135 0.335977692387001 1546 688669
SGTC_2364 9055074 200 µM 0.422155929003078 0.339171145519923 no 1136 0.33645560348852 1537 6470630
SGTC_3187 9109394 49.47 µM 0.420373368420256 0.339820461622246 no 1137 0.337106359996808 1538 17098090
SGTC_2326 6164455 177.58 µM 0.419537264578882 0.340125185044909 no 1138 0.337411763244337 1587 2888790
SGTC_920 mycophenolic acid 780.421 nM 0.419353242691565 0.340192267037314 no 1139 0.337478995223086 1574 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_424 splitomicin 100 mM 0.418799700189812 0.340394081856172 no 1140 0.337681261988757 1555 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_20 0481-0013 4.944 µM 0.417844710218775 0.340742366955786 no 1141 0.338030329568139 1562 182045
SGTC_1347 1493-0251 600 nM 0.416998946590993 0.341050930592054 no 1142 0.338339589111827 1710 3986378
SGTC_2457 5731572 11.68 µM 0.416833256430633 0.341111392519741 no 1143 0.338400187693522 1729 2865357
SGTC_2689 tacrolimus 100 µM 0.416315293797479 0.341300428356486 no 1144 0.338589651402551 1585 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1115 galangin 695.678 nM 0.413457625376112 0.342344079030208 no 1145 0.339635681200741 1673 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_808 0711-0032 135 µM 0.413380385087103 0.342372304760947 no 1146 0.339663971671592 1745 4252555
SGTC_1237 0330-0133 46.1 µM 0.412723822009973 0.342612266544228 no 1147 0.339904484685949 1598 X1237 YHR072W ERG7
SGTC_990 3985-0011 41.3 µM 0.41223226423779 0.342791963502653 no 1148 0.34008459542266 1600 5399565 YGL099W LSG1
SGTC_126 0417-1624 672.48 µM 0.411339381253139 0.343118462410558 no 1149 0.340411848298735 1693 41912 YDL195W SEC31
SGTC_1170 0310-0127 64.8 µM 0.411085937626784 0.343211160041147 no 1150 0.34050476049825 1651 774975
SGTC_2641 levomentholum 100 µM 0.41019453546588 0.343537267493251 no 1151 0.340831624576621 1612 16666
SGTC_1953 st076800 12.1 µM 0.408832853034229 0.344035645468542 no 1152 0.341331164222405 1560 297591
SGTC_2429 5902844 64.44 µM 0.408688241833007 0.344088589339047 no 1153 0.34138423187925 1730 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1192 1488-0095 21.4 µM 0.408355495128362 0.344210423447887 no 1154 0.341506351120936 1626 915875
SGTC_2343 7990716 14.84 µM 0.408019158775135 0.344333588328643 no 1155 0.341629804640627 1651 6456862
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.407141457646047 0.344655076321087 no 1156 0.341952047899357 1603 75037 A free radical scavenger.
SGTC_1355 1499-0035 1.68 µM 0.406254818913973 0.344979951965765 no 1157 0.342277689489247 1589 1548538
SGTC_231 b-estradiol 524 µM 0.405288744569498 0.345334063953311 no 1158 0.342632639461846 1566 450 A steroid.
SGTC_1345 1488-0192 31.4 µM 0.404516302126177 0.345617298136523 no 1159 0.342916546234302 1709 658348
SGTC_1679 SEC14.276 6.7 µM 0.403474633455862 0.345999387315031 no 1160 0.343299546030465 1771 1005053 YMR079W SEC14
SGTC_1102 cgs 12066b 26.1 µM 0.403086026718143 0.34614197036755 no 1161 0.343442469859527 1632 6438352 A 5-HT1B full agonist.
SGTC_1475 4092-1048 11.7 µM 0.403008090671696 0.346170568379546 no 1162 0.343471136284428 1599 2881759
SGTC_1440 4100-1550 40 µM 0.401341080460832 0.34678247432703 no 1163 0.344084511091038 1620 742806
SGTC_2352 9027995 87.8 µM 0.400848451851817 0.346963379097371 no 1164 0.344265851960013 1674 2997347
SGTC_2838 9002687 71.43 µM 0.400120852558762 0.347230634417407 no 1165 0.344533753076738 1566 6457060
SGTC_1274 0865-0114 173 µM 0.39853219171852 0.347814431159123 no 1166 0.345118966873053 1647 870624
SGTC_119 0121-0043 24.815 µM 0.397551050469349 0.348175158679115 no 1167 0.345480574348322 1635 1092378
SGTC_3326 9140064 16.379 µM 0.396480435840411 0.348568938856436 no 1168 0.345875318902934 1564 1868434
SGTC_1813 st051246 8.6015 µM 0.396073401044434 0.34871869218937 no 1169 0.346025440023472 1733 5291959
SGTC_2194 5927483 104.545 µM 0.395105048676607 0.349075056188526 no 1170 0.346382681534242 1654 760979
SGTC_2205 7238770 200 µM 0.39448863709444 0.349301971596003 no 1171 0.34661015738293 1689 279867
SGTC_1631 benzylvanillin 81.9 µM 0.394280856952922 0.349378472433043 no 1172 0.346686847458692 1665 75506
SGTC_1090 efavirenz 20.7 µM 0.39380323149075 0.349554348563009 no 1173 0.346863159214145 1680 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1008 4106-0037 6 µM 0.393475205547961 0.349675156339857 no 1174 0.346984266673456 1640 2905394
SGTC_2390 9097792 176.6 µM 0.391150179568804 0.350531869531949 no 1175 0.34784311569313 1575 4497149
SGTC_948 3448-0295 75.3 µM 0.391019536118052 0.350580030951299 no 1176 0.347891397732977 1607 678569
SGTC_2104 5389443 200 µM 0.389978420014992 0.350963921881008 no 1177 0.348276252215473 1721 2244536
SGTC_237 nikkomycin 200 µM 0.389745978979334 0.351049650699773 no 1178 0.348362196719021 1725 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3099 9120367 49.47 µM 0.389280854348099 0.351221220559204 no 1179 0.348534198787384 1642 24824940
SGTC_560 2332-1943 155 µM 0.388787616797516 0.351403193522548 no 1180 0.348716630977867 1649 21177716
SGTC_694 1315-0438 43.2 µM 0.388429184045708 0.35153545355215 no 1181 0.348849225302759 1693 6793154
SGTC_3120 9124077 49.47 µM 0.385369856625285 0.352665061255553 no 1182 0.349981706086615 1660 18774327 YGL155W CDC43
SGTC_2837 9008476 45.46 µM 0.384801963602258 0.352874890056441 no 1183 0.350192072100638 1693 2992805
SGTC_562 3772-2733 112 µM 0.384014620991219 0.353165876546281 no 1184 0.350483805412359 1725 2876874 YIL048W NEO1
SGTC_1947 st076332 61.6 µM 0.382643621340759 0.353672776185558 no 1185 0.35099201107686 1728 24208416
SGTC_755 1995-0008 37.3 µM 0.381438347564312 0.354118616447275 no 1186 0.351439005348178 1652 689533
SGTC_2149 5554786 194.827 µM 0.380546189506219 0.354448761628484 no 1187 0.35177000826787 1672 745063 YPR165W RHO1
SGTC_3002 9075603 71.4286 µM 0.38007691628202 0.354622461205089 no 1188 0.351944160216604 1651 20105405
SGTC_122 0236-0016 402.397 µM 0.376971056308661 0.355772843371979 no 1189 0.353097557283783 1679 6808838
SGTC_907 3448-6986 75.5 µM 0.374444913387498 0.35670947376676 no 1190 0.354036666585641 1754 590582
SGTC_1677 st019204 53.9 µM 0.374187473607321 0.356804974617247 no 1191 0.354132421407672 1601 3945625
SGTC_1713 st033146 12.748 µM 0.372999028528674 0.357245961048184 no 1192 0.354574583496927 1785 674619
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.37059281932591 0.35813939660388 no 1193 0.35547041558846 1689 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2081 5214970 32.255 µM 0.370365501542587 0.358223840914027 no 1194 0.35555508742397 1759 2063512
SGTC_836 0330-0104 1.35 µM 0.369756354349942 0.358450161900275 no 1195 0.355782019067521 1714 46494820
SGTC_2486 5283202 22.39 µM 0.36974333007701 0.358455001448517 no 1196 0.355786871687491 1621 1377751
SGTC_412 gemfibrozil 100 µM 0.369429222882864 0.358571724015945 no 1197 0.355903909698873 1692 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1681 tripelennamine 100 µM 0.368768033774311 0.35881746575858 no 1198 0.356150316650963 1618 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_118 0083-0097 135.343 µM 0.368267663666824 0.359003475350603 no 1199 0.356336830742662 1680 5207356
SGTC_2905 7799065 20.05 µM 0.36819631737584 0.359030000631756 no 1200 0.356363428035202 1774 1296806
SGTC_960 1222-0186 7.7 µM 0.36743245144823 0.359314034957818 no 1201 0.356648234540646 1736 3126296
SGTC_822 1487-0950 154 µM 0.366088777527147 0.359813852512992 no 1202 0.357149415684804 1785 1958375
SGTC_2910 7948405 25.97 µM 0.365392508045494 0.360072944052937 no 1203 0.357409216466244 1795 2971328
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.365028292615722 0.360208499290145 no 1204 0.357545143425389 1560 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2874 9043904 71.43 µM 0.364610570247683 0.360363990605409 no 1205 0.357701061681757 1670 4463428
SGTC_496 calpeptin 138 µM 0.363445900823013 0.360797644432469 no 1206 0.358135909318651 1636 73364 A calpain inhibitor.
SGTC_1481 3346-2004 36 µM 0.361296077706245 0.361598580981033 no 1207 0.358939062758584 1695 2770522
SGTC_863 0466-0191 129 µM 0.358829850953938 0.362518143857147 no 1208 0.359861189989056 1784 765160 YPR165W RHO1
SGTC_266 formosanin C 406 nM 0.356477575947906 0.363395958126084 no 1209 0.360741471189935 1721 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2433 5607874 27.82 µM 0.354269854588226 0.364220481518701 no 1210 0.361568328593704 1637 2252428
SGTC_3054 9094397 49.47 µM 0.353588165713727 0.364475200859622 no 1211 0.361823772268834 1623 2598354
SGTC_1393 3470-5649 58.2 µM 0.352270167725399 0.364967852628446 no 1212 0.362317829366992 1682 4108395
SGTC_2368 9071271 200 µM 0.352162503049374 0.365008106250086 no 1213 0.362358198071277 1638 27209959
SGTC_1183 1254-0324 198 µM 0.351945366457173 0.365089293708965 no 1214 0.362439617757662 1778 5799357
SGTC_74 000s-0487 160.283 µM 0.351595188167601 0.365220238252017 no 1215 0.362570937183696 1658 677548
SGTC_375 3970-0961 9.27 µM 0.350128944456372 0.365768691212998 no 1216 0.363120964753781 1732 2898222
SGTC_2965 9082772 38.63 µM 0.34764283010981 0.366699256672756 no 1217 0.364054218215081 1867 16459634
SGTC_1547 harmine 94.2 µM 0.345708809920704 0.367423712968617 no 1218 0.364780781350364 1699 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3341 9147222 25.867 µM 0.345218090489784 0.367607604642743 no 1219 0.364965209785156 1728 1939759
SGTC_3077 9117319 49.47 µM 0.34451904682581 0.36786961593498 no 1220 0.365227987238947 1728 17154678
SGTC_1627 st003713 25.6 µM 0.343890738177559 0.368105167238481 no 1221 0.365464228711834 1684 16195070 YER133W GLC7
SGTC_327 1273-0057 3.96 µM 0.342769364242173 0.368525690656138 no 1222 0.36588598751706 1746 3108138
SGTC_234 nsc-17383 10.7 µM 0.341771309702294 0.368900100904515 no 1223 0.366261501182189 1813 408974
SGTC_1356 1502-0781 85.8 µM 0.340382537545989 0.369421291987586 no 1224 0.366784233732312 1718 567702
SGTC_2315 7733312 200 µM 0.339432143344438 0.369778103015963 no 1225 0.367142103728386 1674 726316
SGTC_2175 5807670 165.306 µM 0.338903897425162 0.369976473412084 no 1226 0.367341064149279 1805 241186
SGTC_407 eburnamonine 100 µM 0.338375349530041 0.370174991837333 no 1227 0.367540173959968 1676 3195
SGTC_433 pimozide 108 µM 0.337523049559505 0.370495181831077 no 1228 0.367861319736392 1591 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2964 9083345 53.42 µM 0.337216013993705 0.370610550208139 no 1229 0.367977033079572 1660 17741579
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.336715833973268 0.370798517379303 no 1230 0.368165562960736 1788 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1670 st016595 4.04 µM 0.336045685009161 0.371050407048372 no 1231 0.368418207991903 1766 597879
SGTC_1149 3909-7961 23.3 µM 0.335802232059877 0.371141927680227 no 1232 0.368510003439756 1665 735261
SGTC_1080 nisoldipine 24.4 µM 0.335661982898318 0.371194654490449 no 1233 0.368562888665231 1707 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_133 0724-0033 378.92 µM 0.335567536858778 0.371230162934275 no 1234 0.368598503828946 1730 280309
SGTC_3168 9103419 49.47 µM 0.33413336671201 0.371769495840074 no 1235 0.369139461289249 1800 16649256
SGTC_558 k064-0027 21.3 µM 0.334089712655929 0.371785916303867 no 1236 0.36915593131993 1797 5088526
SGTC_2492 derrusnin 100 µM 0.333974130013761 0.371829393816111 no 1237 0.369199540103792 1694 1715307 Part of coumarin class of compounds.
SGTC_285 1486-1325 46 µM 0.332720848964463 0.372300932274807 no 1238 0.369672505092026 1784 22310230
SGTC_1422 4031-0024 15.5 µM 0.330324373978999 0.373203122396065 no 1239 0.370577438911562 1819 782427
SGTC_2468 5987765 72.9 µM 0.330171631135418 0.373260648438613 no 1240 0.370635140536835 1777 26772094
SGTC_701 4424-0219 185 µM 0.328859201443324 0.373755052293426 no 1241 0.371131056569363 1859 2911779
SGTC_1451 4152-0210 104 µM 0.328693067508749 0.373817651248063 no 1242 0.37119384738973 1848 659563
SGTC_2111 5486399 200 µM 0.328335317992251 0.373952461893451 no 1243 0.371329071535623 1703 689674
SGTC_1705 st027868 56.3335 µM 0.327846261179167 0.374136777973237 no 1244 0.371513953638411 1828 292948
SGTC_386 1509-0011 3.07 µM 0.327629922351379 0.374218321087282 no 1245 0.37159574741521 1726 3107280
SGTC_2651 TUB2.036 5 µM 0.327568020689711 0.374241654292702 no 1246 0.371619152374779 1820 15992207 YFL037W TUB2
SGTC_158 k038-0087 26.446 µM 0.325493100293235 0.375024040573701 no 1247 0.372403951875334 1753 X158
SGTC_993 3909-8757 62.7 µM 0.324524649147221 0.375389388929251 no 1248 0.372770431925387 1751 4288324 YLR208W SEC13
SGTC_1262 0737-0114 49.6 µM 0.323278951651103 0.375859492863149 no 1249 0.373241996529352 1877 765919
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.322962489072024 0.375978949562072 no 1250 0.37336182519834 1832 6710655
SGTC_2665 lovastatin 100 µM 0.32132269611817 0.376598120451647 no 1251 0.373982929301983 1760 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2157 5649910 96.377 µM 0.320746829984495 0.376815637696556 no 1252 0.374201127763314 1699 2858091
SGTC_1240 0356-0016 42.1 µM 0.320268776270835 0.376996238760823 no 1253 0.374382295247457 1777 4305613
SGTC_1811 st050069 61.5 µM 0.317549742497577 0.378023957124932 no 1254 0.375413250929803 1876 3877702
SGTC_2274 7947094 46.08 µM 0.317247629219356 0.378138200906716 no 1255 0.375527856056742 1705 2971028
SGTC_1471 k673-0312 37 µM 0.316935915887459 0.378256086106862 no 1256 0.375646114428795 1852 24099884
SGTC_2341 7987486 176.74 µM 0.316263844168162 0.378510291868905 no 1257 0.375901125960834 1896 1258686
SGTC_2727 riluzole 51.77 µM 0.315303036866023 0.378873800857396 no 1258 0.376265789716743 1818 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2025 5147754 141 µM 0.31420349021778 0.379289931562683 no 1259 0.376683246008675 1851 315777 YLR208W SEC13
SGTC_547 1120-0019 610 nM 0.314179478691955 0.379299020446134 no 1260 0.376692363888303 1753 3676939
SGTC_1049 3226-0134 66 µM 0.313679709688809 0.379488208994094 no 1261 0.376882156424403 1767 5702385
SGTC_1479 0549-0158 134 µM 0.313072878098649 0.379717965087258 no 1262 0.377112647099969 1737 5440202
SGTC_3220 9131269 49.47 µM 0.312871112124239 0.3797943663069 no 1263 0.377189292854315 1758 17722206
SGTC_1904 st060225 78 µM 0.31172741143823 0.38022753153792 no 1264 0.377623846978159 1734 66595
SGTC_1219 1469-0211 33.1 µM 0.310884200675212 0.380546985468736 no 1265 0.377944327894052 1863 6822282
SGTC_901 1112-0062 60.1 µM 0.309288625060605 0.381151698764968 no 1266 0.378550991481777 1761 1908457
SGTC_2289 7946404 165.07 µM 0.308306972665367 0.381523883312498 no 1267 0.378924380439915 1711 1246120 YPR165W RHO1
SGTC_2985 9022375 71.43 µM 0.307001622042853 0.382018964772195 no 1268 0.379421068795909 1772 4939335
SGTC_1227 3909-8010 46.6 µM 0.306822580018028 0.382086885264518 no 1269 0.37948921016474 1783 15982272
SGTC_2304 7443016 91.4 µM 0.306684805999207 0.38213915300208 no 1270 0.379541647946116 1752 939854
SGTC_319 1348-1596 45.5 µM 0.303668763832786 0.383283894486219 no 1271 0.380690128853447 1892 5380505
SGTC_2237 6667747 47.222 µM 0.303140380072212 0.383484548276348 no 1272 0.380891441091936 1728 729940 YDL015C TSC13
SGTC_1431 4049-0260 9.09 µM 0.302447440867732 0.383747739376991 no 1273 0.381155497207584 1835 3854841
SGTC_1161 k007-0610 110 µM 0.302289540513362 0.383807720354348 no 1274 0.381215675535091 1843 5843850
SGTC_2119 5528445 120.635 µM 0.30196562257643 0.383930774479716 no 1275 0.381339134783312 1872 791935
SGTC_1299 1079-1439 3.74 µM 0.301600025584394 0.384069676241102 no 1276 0.381478494243188 1734 323161
SGTC_649 1123-0311 367 µM 0.300569394936331 0.384461325253322 no 1277 0.381871436078318 1872 693629 YIL048W NEO1
SGTC_2933 9026794 32.47 µM 0.299053561876317 0.385037569841365 no 1278 0.3824495889744 1823 17586027
SGTC_3275 9138069 49.47 µM 0.296923571313827 0.385847715613579 no 1279 0.383262429983428 1827 17617007
SGTC_1674 st016616 23.6 µM 0.296431268557958 0.386035034861533 no 1280 0.383450374462763 1672 625830
SGTC_2537 larixol 68.93 µM 0.296007746385046 0.386196204635083 no 1281 0.383612082800902 1817 6708759
SGTC_2097 5376186 200 µM 0.295946569991777 0.38621948670596 no 1282 0.383635442718064 1883 742755
SGTC_2321 7390090 138.78 µM 0.294820536363398 0.386648097561883 no 1283 0.384065488800081 1718 649046
SGTC_1615 st002656 86.5 µM 0.2946870104023 0.386698931760039 no 1284 0.384116493485362 1770 1584458
SGTC_1392 3455-1037 33.9 µM 0.293958014781128 0.38697649937316 no 1285 0.384394992995721 1872 981132
SGTC_3085 9117376 49.47 µM 0.2938255078012 0.387026958078921 no 1286 0.384445621290491 1824 16480349
SGTC_1765 st044815 90.4 µM 0.292486904849374 0.387536805497322 no 1287 0.384957185389717 1726 645695
SGTC_2969 9091408 28.7 µM 0.291574517800005 0.387884426938821 no 1288 0.385305980531364 1688 4286311
SGTC_1773 st048542 73.5835 µM 0.290320632087547 0.388362306683412 no 1289 0.385785478059774 1723 3237138
SGTC_3181 9108277 49.47 µM 0.289411564827666 0.388708875296573 no 1290 0.386133223021485 1774 17097298
SGTC_1337 1486-1011 40.3 µM 0.288170167367859 0.389182282998147 no 1291 0.386608241798358 1872 X1337
SGTC_1740 st038286 13.222 µM 0.285489010118744 0.390205304629731 no 1292 0.387634761444358 1829 716786
SGTC_1658 st012944 20 µM 0.284864243245676 0.390443800065632 no 1293 0.387874075606503 1870 24207260
SGTC_3234 9132280 49.47 µM 0.284698768517376 0.390506974485115 no 1294 0.387937467101032 1815 17612295
SGTC_2869 9037858 32.47 µM 0.284302950647201 0.390658100306843 no 1295 0.38808911255748 1778 27187042
SGTC_1408 3909-7976 48.8 µM 0.2824016585549 0.391384255779141 no 1296 0.38881777169454 1836 24152374
SGTC_1836 st055642 81 µM 0.282284088651666 0.391429171400845 no 1297 0.388862842548996 1735 8571
SGTC_428 3448-4153 16.5 µM 0.281021816144315 0.391911492661129 no 1298 0.389346833478377 1707 3834874
SGTC_677 0929-0063 136 µM 0.280532998662341 0.392098317179105 no 1299 0.38953430606943 1792 1539583
SGTC_2508 celastrol 40.54 µM 0.280128142562838 0.392253070755643 no 1300 0.389689597032791 1863 122724 Celastrol is a natural product and antioxidant.
SGTC_1548 st061468 90.8 µM 0.278206352381432 0.392987894451103 no 1301 0.390426979394276 1923 390799
SGTC_737 1950-0117 57.9 µM 0.278169350656163 0.393002046336468 no 1302 0.390441180669525 1939 5393513
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.277775785626193 0.39315258015188 no 1303 0.390592240109433 1947 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3178 9107506 49.47 µM 0.277227866486086 0.393362179129873 no 1304 0.390802571754039 1852 8897194
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.275281745997192 0.394106890395519 no 1305 0.391549893745998 1886 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2342 7990637 118.86 µM 0.271782436887698 0.395446924563528 no 1306 0.392894655205713 1835 2033102 YER133W GLC7
SGTC_3285 9112818 20.8695 µM 0.271008369964419 0.39574351533649 no 1307 0.393192297391195 1836 17017947 YPR165W RHO1
SGTC_2771 fluoxetine 41.05 µM 0.26974533981999 0.396227586375138 no 1308 0.393678088431268 1910 3386 A selective serotonin reuptake inhibitor.
SGTC_2022 5136654 200 µM 0.268884561282069 0.396557581541262 no 1309 0.394009258956024 1841 1713771
SGTC_1331 1472-0049 76.2 µM 0.268806401264393 0.396587549284463 no 1310 0.39403933354978 1786 24051409
SGTC_2056 5235370 200 µM 0.267991692161009 0.396899957522335 no 1311 0.394352856805471 1791 5511916
SGTC_3333 9141820 12.094 µM 0.266137562428989 0.397611188240049 no 1312 0.395066633595169 1800 1939433
SGTC_355 1311-2252 105 µM 0.265754116804657 0.397758317767557 no 1313 0.395214291137462 1780 5338538
SGTC_2427 5545055 42.75 µM 0.263174068181241 0.398748669284942 no 1314 0.396208208537598 1848 5372858
SGTC_2423 st077119 87.2 µM 0.261625800459665 0.399343285350582 no 1315 0.396804975385137 1889 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.259608216363704 0.4001184938881 no 1316 0.397582998923508 1887 4000243
SGTC_2750 bromebric acid 70.15 µM 0.259518162045694 0.400153104312404 no 1317 0.39761773531778 1851 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1224 0823-0416 294 µM 0.259340799468791 0.400221272065763 no 1318 0.397686151250517 1913 3598164
SGTC_93 0109-0045 59.227 µM 0.258308752067876 0.400617990694562 no 1319 0.398084316121902 1973 88733
SGTC_1055 3448-0672 86 µM 0.257926537902571 0.400764939715061 no 1320 0.398231801670512 1863 748378
SGTC_349 k015-0014 24 µM 0.257902459387689 0.400774197597971 no 1321 0.398241093369937 1794 2196908
SGTC_3094 9117742 49.47 µM 0.25757767568896 0.400899078245573 no 1322 0.398366430344902 1851 17149698
SGTC_1545 lovastatin 49.4 µM 0.257228181759732 0.401033471389271 no 1323 0.39850131493435 1875 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1292 0kpi-0043 232 µM 0.257002790380571 0.401120148796018 no 1324 0.398588309498203 1832 3333905
SGTC_1374 2889-5571 141 µM 0.255327992053182 0.401764368086607 no 1325 0.39923489085953 1823 2853281
SGTC_3163 9099914 49.47 µM 0.253429858142622 0.402494817246362 no 1326 0.399968028556195 1954 16268368
SGTC_382 3229-0966 23.2 µM 0.253391798869046 0.402509466892973 no 1327 0.399982732234953 1949 5722370
SGTC_262 fenpropimorph 62.5 µM 0.251830131804721 0.40311069632206 no 1328 0.400586182956279 1832 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3197 9113331 49.47 µM 0.250981869192595 0.40343736682047 no 1329 0.40091406345936 1963 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_63 0099-0242 26.702 µM 0.249917329706954 0.403847422031764 no 1330 0.401325640613899 1996 3898502 YLR359W ADE13
SGTC_1605 st000082 49.1 µM 0.248830586219468 0.404266139138478 no 1331 0.40174591534218 1926 1114022
SGTC_941 3237-0776 460 µM 0.247440624541956 0.404801844585961 no 1332 0.402283618796223 1958 760008
SGTC_156 3474-0145 5.642 µM 0.247131871059714 0.404920865596645 no 1333 0.402403084506307 2010 2265471
SGTC_1270 0831-1170 17.3 µM 0.246487815049433 0.4051691702775 no 1334 0.402652317853777 1886 6764716
SGTC_1033 k072-0102 21.3 µM 0.2463471935986 0.405223389532596 no 1335 0.402706740056393 1992 5965931
SGTC_913 3487-1245 167 µM 0.245972543313439 0.405367851899346 no 1336 0.402851743448912 1799 4016153
SGTC_823 0417-1665 178 µM 0.244838407857081 0.405805244617814 no 1337 0.403290776817181 1884 3429856
SGTC_3264 9137442 49.47 µM 0.244152104665377 0.406069982699466 no 1338 0.403556509800811 1973 17015726
SGTC_154 3389-1638 511.116 µM 0.2431971177046 0.406438435672485 no 1339 0.403926349793434 1735 5238686
SGTC_778 3456-2434 196 µM 0.242414033281233 0.40674062706986 no 1340 0.404229680811959 2006 5539063
SGTC_1301 naphtanilide LB 4.81 µM 0.240202223210698 0.407594461502824 no 1341 0.405086745128431 1975 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2846 9008642 19.48 µM 0.23920138770242 0.407980962846602 no 1342 0.405474713332545 1846 2992898
SGTC_1310 1188-0297 994 nM 0.238934977239816 0.408083859997908 no 1343 0.405578001505566 1938 1588352
SGTC_1884 5633444 25 µM 0.238468302820762 0.408264121452479 no 1344 0.405758948485682 1897 5724239
SGTC_806 3966-4455 5.86 µM 0.237559763761319 0.408615116794322 no 1345 0.406111280507412 1822 714982
SGTC_3148 9097893 49.47 µM 0.237509542225892 0.408634520990389 no 1346 0.406130758671315 1773 17174100
SGTC_2536 dehydroabietamide 32.04 µM 0.237018151670273 0.408824392361665 no 1347 0.406321354218973 1991 3983547
SGTC_1119 parthenolide 318.541 nM 0.236456421710119 0.40904146881235 no 1348 0.406539259487303 1943 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_760 0568-0725 82.9 µM 0.235849927074795 0.409275875567685 no 1349 0.406774562282388 2018 3916171
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.235618886000176 0.409365180177784 no 1350 0.406864208554491 1882 688788
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.235160289975178 0.40954245583164 no 1351 0.407042162900117 1893 4213774
SGTC_406 estrone 100 µM 0.233484025127186 0.410190592709055 no 1352 0.40769278645081 2017 5870 A steroid.
SGTC_301 4119-0100 24.5 µM 0.233464318504135 0.410198213844465 no 1353 0.407700436875391 1876 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2100 5377183 190 µM 0.232124438670723 0.410716464505386 no 1354 0.408220681949577 1957 2844202
SGTC_1630 st005209 31.3 µM 0.231986865719437 0.410769685038512 no 1355 0.408274107595126 2053 3367314
SGTC_1197 1601-0112 267 µM 0.231210529652394 0.411070043876299 no 1356 0.408575625067857 1832 7350313
SGTC_1376 2910-0861 41.3 µM 0.230002558459452 0.411537502865896 no 1357 0.409044890823655 1919 1112859
SGTC_2882 9058044 58.44 µM 0.229697462919072 0.411655588201439 no 1358 0.409163433249928 1801 18076804
SGTC_900 1112-0045 141 µM 0.229193060322588 0.411850831641977 no 1359 0.409359433051033 2004 56211 YIL048W NEO1
SGTC_2681 menadione 3.18 µM 0.227158478093777 0.412638595930191 no 1360 0.410150256700265 1926 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2546 rhodinyl acetate 100 µM 0.227136981606208 0.412646920980767 no 1361 0.410158614147068 2032 6708682
SGTC_791 1348-1292 225 µM 0.226060736012504 0.41306377406652 no 1362 0.410577091118185 1976 5437054
SGTC_1682 st012968 530 nM 0.223731364147561 0.413966325057942 no 1363 0.411483169720527 1823 24207270
SGTC_486 niguldipine 82 µM 0.223195034624413 0.414174198748867 no 1364 0.411691858136902 1957 1236 A calcium channel blocker.
SGTC_2591 skatole 100 µM 0.222514301731136 0.414438075753126 no 1365 0.411956770574941 1899 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_475 α-linolenic acid 10 µM 0.221685304139297 0.414759477731009 no 1366 0.412279435541148 2017 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1131 3454-3128 32.3 µM 0.221532826388119 0.414818599503735 no 1367 0.412338789858863 1959 710982
SGTC_767 0929-0023 86 µM 0.221434864084231 0.414856584457318 no 1368 0.412376924255359 1964 1204563
SGTC_1803 st050068 52.4 µM 0.219589572478761 0.415572245946028 no 1369 0.413095406582504 1966 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2900 5328528 85.29 µM 0.217995281393737 0.416190787298017 no 1370 0.4137163939618 1926 795359
SGTC_3266 9136860 49.47 µM 0.2176863653804 0.416310662326047 no 1371 0.413836743892607 1911 4871271 YPR165W RHO1
SGTC_603 3794-0023 45.9 µM 0.217471607888256 0.416394003676335 no 1372 0.413920415575642 2023 3802260
SGTC_1905 st060207 84.5 µM 0.215408440851353 0.41719485183313 no 1373 0.414724444813026 1903 1948547
SGTC_2466 5983409 37.09 µM 0.215360850028025 0.417213328968042 no 1374 0.414742995487522 1909 2879657
SGTC_2786 7743617 45.45 µM 0.214109013740272 0.417699419884277 no 1375 0.415231023419343 1843 583674
SGTC_696 1560-0013 611 µM 0.213722653774754 0.417849469784282 no 1376 0.415381672167655 1986 1650269
SGTC_3247 9135149 49.47 µM 0.213615323191227 0.417891155686733 no 1377 0.415423524515017 1949 8934436 YOR116C RPO31
SGTC_1716 st033144 30.6155 µM 0.21350878747114 0.417932533786152 no 1378 0.415465067863315 2040 674617
SGTC_829 1635-0120 117 µM 0.213484101347338 0.417942121919576 no 1379 0.415474694292899 2025 285054
SGTC_1124 fisetin 1.16336 µM 0.213450720829544 0.417955087048314 no 1380 0.415487711208727 1861 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1068 loratadine 26.9 µM 0.211677249806289 0.418644038270279 no 1381 0.416179418967901 1905 3957 A H1 histamine antagonist.
SGTC_958 1222-0007 33 µM 0.211110618649063 0.418864213688913 no 1382 0.416400477237917 1986 7312461
SGTC_2292 7671323 168.05 µM 0.211073944675726 0.418878464942067 no 1383 0.41641478566716 1919 937504
SGTC_33 0986-0033 35.816 µM 0.211050855636007 0.418887437238301 no 1384 0.416423793962274 2026 2848082
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.210881547495464 0.41895323090336 no 1385 0.416489851653393 1981 165521
SGTC_1877 wortmannin 25 µM 0.208166521480921 0.420008606781569 no 1386 0.417549473978693 2046 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1312 1218-2183 165 µM 0.207408557748632 0.420303343001996 no 1387 0.417845399898179 2043 6744073
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.206648386680012 0.420598982441012 no 1388 0.418142234339824 1953 364106
SGTC_1334 1486-0610 236 µM 0.206526550474705 0.420646370138525 no 1389 0.418189813737153 1980 3742339
SGTC_940 3232-1287 54.8 µM 0.205873762235841 0.420900289044905 no 1390 0.418444760559755 2083 1585493 YIL048W NEO1
SGTC_1130 3454-2858 15.9 µM 0.202915433213432 0.422051418799074 no 1391 0.419600565629293 1860 715628 YIL048W NEO1
SGTC_2675 theaflavin digallate 100 µM 0.201370440538384 0.422652863857574 no 1392 0.420204463403849 1973 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2361 9034121 116 µM 0.200840532715063 0.422859191521039 no 1393 0.420411634047754 1934 6496917
SGTC_2270 7924575 90.91 µM 0.200256975772272 0.423086432767718 no 1394 0.420639804645994 2080 1262135
SGTC_2724 maprotiline 69.64 µM 0.198981057065615 0.423583373683332 no 1395 0.421138781284566 2024 4011 A tricyclic antidepressant.
SGTC_623 k072-0108 16.9 µM 0.198555062144766 0.423749315990958 no 1396 0.42130540440731 1976 5382803
SGTC_3209 9113616 49.47 µM 0.197792722618832 0.424046311905361 no 1397 0.421603620100179 2117 16649353
SGTC_1855 st056195 39.6 µM 0.195090925815732 0.425099237229597 no 1398 0.422660883121521 2076 4028379
SGTC_726 3448-4391 34.2 µM 0.194584844912192 0.425296523198939 no 1399 0.422858984141137 2021 1356692
SGTC_2732 terfenadine 20 µM 0.192893630762977 0.425955946161897 no 1400 0.423521136638135 2052 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_209 4077-0173 175.592 µM 0.192792577390705 0.425995354556591 no 1401 0.42356070841072 1997 15993494
SGTC_3317 9138495 8.753 µM 0.192632684657411 0.426057710402465 no 1402 0.423623322828038 2082 17020139
SGTC_3177 9107506 49.47 µM 0.191132691604093 0.426642775748242 no 1403 0.424210817777578 2075 8897194
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.190848967048443 0.426753459393567 no 1404 0.424321961772058 1930 5282362
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.189063098034325 0.427450275935297 no 1405 0.425021681670541 1992 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1145 3546-0597 10.2 µM 0.189016307794234 0.427468535765638 no 1406 0.425040017702769 1981 875334
SGTC_1285 0929-0069 65.5 µM 0.188695234593532 0.427593838353687 no 1407 0.425165843369082 1960 1206237
SGTC_2152 5568786 200 µM 0.188217112411915 0.427780444683648 no 1408 0.425353229227108 2013 5399883
SGTC_2252 omeprazole 400 µM 0.187531568032834 0.428048034011374 no 1409 0.42562193749918 2036 4594 A proton pump inhibitor.
SGTC_899 1083-0020 478 µM 0.187287117384692 0.428143458724774 no 1410 0.425717761556527 2056 767123
SGTC_157 1348-1695 65.819 µM 0.187063597821527 0.428230716375811 no 1411 0.425805384519562 2008 5380510
SGTC_633 0437-0093 97.7 µM 0.186239323686465 0.428552527121709 no 1412 0.426128543763926 1989 2831118
SGTC_1277 0873-0036 22 µM 0.18584019895167 0.428708369343226 no 1413 0.426285039701329 2046 5965735
SGTC_84 0443-0269 128.823 µM 0.18506032252753 0.429012911907534 no 1414 0.426590861024212 2068 6150058
SGTC_824 1304-0008 100 µM 0.184155963685506 0.429366117897381 no 1415 0.42694555223472 1966 768245
SGTC_997 3996-0078 137 µM 0.183953915103428 0.429445037641529 no 1416 0.427024804145925 1971 735687
SGTC_1568 digitonin 820 nM 0.183111407380662 0.429774149716674 no 1417 0.427355302654952 2121 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_709 3807-1509 243 µM 0.182727935266558 0.429923963099795 no 1418 0.427505747804324 2070 1886677 YPL242C IQG1
SGTC_9 0092-0002 10.449 µM 0.182493440793928 0.430015579454639 no 1419 0.427597750709046 2044 759368
SGTC_1742 st038235 28.8875 µM 0.182341197733034 0.430075062423613 no 1420 0.427657484731904 1969 564103 YBR002C RER2
SGTC_1671 st016596 74.5 µM 0.180272821724347 0.430883355436988 no 1421 0.42846919561381 2017 2829167
SGTC_3191 9110352 49.47 µM 0.180201762680661 0.430911129502811 no 1422 0.428497087333473 2020 17122424
SGTC_2867 9039098 71.43 µM 0.179299422659073 0.431263846882633 no 1423 0.42885130007921 1952 6463460
SGTC_374 0880-0231 82.3 µM 0.179033481774018 0.431367811485121 no 1424 0.428955705876405 2059 6833587
SGTC_584 0986-0246 15.4 µM 0.177581778829929 0.431935411168304 no 1425 0.429525717735909 2104 53315 YDR232W HEM1
SGTC_1030 k029-0042 36.7 µM 0.177257405701697 0.432062256699165 no 1426 0.429653103129963 1980 6080581
SGTC_817 1391-0715 46 µM 0.17345914910998 0.433548075899198 no 1427 0.431145267690909 1949 1353946
SGTC_2763 lisinopril 49.32 µM 0.171701750077408 0.434235862439423 no 1428 0.431836004943181 2135 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_163 TUB2.036 7.546 µM 0.168199318691431 0.435607187495073 no 1429 0.43321323845762 2125 15992207 YJR013W GPI14
SGTC_2251 lansoprazole 556 µM 0.166951529958029 0.436095928674628 no 1430 0.433704093518629 1914 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_189 3970-0742 2.116 µM 0.166560466778863 0.43624912270655 no 1431 0.433857951012509 2117 2891807
SGTC_2338 7999974 200 µM 0.165881413674472 0.43651515584129 no 1432 0.434125137289516 2126 315925
SGTC_1268 0828-0275 2.46 µM 0.16520005975804 0.436782119231201 no 1433 0.434393259115677 2050 745337
SGTC_809 3998-0021 90 µM 0.164993600604703 0.436863018321816 no 1434 0.434474509501645 2133 715485
SGTC_898 1000-0849 28.3 µM 0.163362065722464 0.437502412634286 no 1435 0.435116684387648 2125 6751807
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.162816775039419 0.437716147126271 no 1436 0.435331349971032 1959 4174840
SGTC_984 1492-0255 2.91 µM 0.161548070465837 0.438213504281022 no 1437 0.435830876880997 2028 1585198
SGTC_2864 9034755 47.6 µM 0.160619564830091 0.438577558660883 no 1438 0.436196522234508 2159 4930451
SGTC_2760 etidronate 98.04 µM 0.160576635236199 0.438594392027875 no 1439 0.436213429222283 2018 3305 A chelator and antioxidant.
SGTC_3253 9135987 49.47 µM 0.160473963208142 0.438634651790659 no 1440 0.436253865081465 2059 4182430
SGTC_2594 a-mangostin 100 µM 0.160160987903097 0.438757379605237 no 1441 0.436377129883843 2105 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_615 k087-0205 167 µM 0.159948709940906 0.43884062406293 no 1442 0.43646073872299 2000 9642773
SGTC_2231 micatex 6.853 µM 0.15974149088679 0.438921887287484 no 1443 0.436542357774015 2055 20737 An antifungal of unknown mechanism.
SGTC_2765 myclobutanil 7.74 µM 0.159660948177718 0.438953473689133 no 1444 0.43657408251401 2008 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2066 5222451 176 µM 0.159557901147499 0.438993886168143 no 1445 0.436614672012295 2106 2281147
SGTC_2630 antimycin a 100 µM 0.158984969405116 0.439218587314988 no 1446 0.436840357942815 2060 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_504 lovastatin 124 µM 0.15794613850275 0.439626061836825 no 1447 0.437249620534935 1950 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3097 9117246 49.47 µM 0.157750347747533 0.439702866637526 no 1448 0.437326762694273 2136 16423892
SGTC_729 4092-0585 94.1 µM 0.157191418295977 0.43992213596933 no 1449 0.437546995715909 1976 2169061
SGTC_1712 st032288 53.4 µM 0.157019749432328 0.439989485768694 no 1450 0.437614641686701 2048 2883011
SGTC_2620 irigenin 100 µM 0.154982978174186 0.440788691823691 no 1451 0.43841736830201 2082 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1482 3346-2049 8.48 µM 0.154780646888703 0.440868097562043 no 1452 0.438497124436353 2110 3826804
SGTC_1249 0481-0015 10.2 µM 0.154232498620276 0.441083232522543 no 1453 0.438713209280436 2027 4227577
SGTC_1198 1612-1005 86.7 µM 0.152689972643227 0.441688729831544 no 1454 0.439321384354379 2121 6998509
SGTC_2851 9015922 71.43 µM 0.151213080248363 0.442268591321341 no 1455 0.439903816197364 2101 2996893
SGTC_2090 5301565 104.445 µM 0.150837997312835 0.44241587714755 no 1456 0.440051755824726 2037 2056344
SGTC_2529 gangaleoidin 93.61 µM 0.150316961380706 0.442620488323081 no 1457 0.440257275890758 2050 4565183
SGTC_1774 st048371 48.465 µM 0.149740810495454 0.44284676099713 no 1458 0.440484554518531 2004 4242727
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.148681807942417 0.443262713363288 no 1459 0.440902358412856 2111 6312947
SGTC_515 4092-1064 102 µM 0.147408234863277 0.443763026981059 no 1460 0.441404903023688 2156 717353
SGTC_1832 st054113 55 µM 0.147354867838396 0.443783993778451 no 1461 0.441425963409991 2154 1251267
SGTC_392 N-ethylmaleimide 8.33 µM 0.147149960178431 0.443864499210359 no 1462 0.441506828261948 2024 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_183 3914-0051 30.55 µM 0.146613807118937 0.444075157405791 no 1463 0.441718427476974 2167 1596232
SGTC_1571 st070080 73.4 µM 0.146558266894029 0.444096980443356 no 1464 0.441740348042579 2094 4315245
SGTC_1485 3909-9022 254 µM 0.145637868118294 0.444458651016588 no 1465 0.442103636125944 2134 714516
SGTC_210 3551-0445 56.827 µM 0.14551464062219 0.44450707676158 no 1466 0.442152278617079 2100 2865180 YOR207C RET1
SGTC_471 1-acyl-paf 4 µM 0.143395668316637 0.445339916107022 no 1467 0.442988851902675 2008 16759367
SGTC_2483 5729050 27.16 µM 0.142786162215076 0.445579520792207 no 1468 0.44322953302326 2146 2865180
SGTC_2439 5492030 7.2 µM 0.142141144833226 0.445833107066165 no 1469 0.443484259611909 2159 5722370
SGTC_1804 st050076 49.1 µM 0.142028733349165 0.445877303509004 no 1470 0.443528654907333 2099 3895976
SGTC_1079 idarubicin 2.36 µM 0.140746278628366 0.446381569360982 no 1471 0.444035191950818 2181 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_559 1550-0661 158 µM 0.139442264746858 0.446894401273475 no 1472 0.444550338067746 2072 5830875
SGTC_3291 9121177 71.43 µM 0.138436752438343 0.447289901621851 no 1473 0.444947626196386 2050 17015612
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.137532597112411 0.447645579779844 no 1474 0.445304914387627 2106 6708784 An antioxidant flavonoid
SGTC_1087 pterostilbene 9.05 µM 0.137367555654662 0.447710508621257 no 1475 0.445370137370531 2149 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2924 9010168 62.78 µM 0.137321511595461 0.447728623031582 no 1476 0.445388333855704 2050 2993929
SGTC_2425 5628681 7.85 µM 0.137300791779198 0.447736774547714 no 1477 0.445396522307469 2097 5714958
SGTC_1254 0550-0035 264 µM 0.136538911830663 0.448036525936148 no 1478 0.445697632689602 2109 15121435
SGTC_1269 0831-0796 3.05 µM 0.132989143893499 0.449433522745665 no 1479 0.447100983076632 2154 927758
SGTC_1730 st033808 45.1 µM 0.132639312395408 0.449571231738363 no 1480 0.447239320148496 1996 1045166
SGTC_1226 3909-7979 35.4 µM 0.132026936828122 0.449812304182011 no 1481 0.447481492868314 2151 6615510
SGTC_2740 felodipine 17.08 µM 0.129900808502416 0.450649435333045 no 1482 0.44832245230868 2187 3333 L-type calcium channel blocker
SGTC_1282 0886-0010 32.4 µM 0.129895133060014 0.450651670248914 no 1483 0.448324697460719 2169 2836211 YNL267W PIK1
SGTC_2007 4011539 71.82 µM 0.129649240673487 0.450748500994335 no 1484 0.448421971781964 2094 45595301
SGTC_2635 hydroquinidine 100 µM 0.129483140660993 0.450813911706072 no 1485 0.448487682224701 2079 442912 An experimental heart treatment.
SGTC_3309 9129340 25.759 µM 0.128335506116802 0.451265890234879 no 1486 0.448941733798789 2121 17158987
SGTC_1024 4507-0395 26 µM 0.128273786644462 0.451290199312457 no 1487 0.448966154468761 2065 4201836
SGTC_3043 9092303 49.47 µM 0.128231273369999 0.45130694386658 no 1488 0.44898297589556 2079 25236084
SGTC_1557 sumaresinolic acid 42.3 µM 0.126837476069707 0.451855961725961 no 1489 0.449534516825089 2105 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2749 bexarotene 57.39 µM 0.125805291032696 0.452262599636634 no 1490 0.449943026707738 2040 82146 An retinoic acid receptor inhibitor.
SGTC_132 0417-1715 25.805 µM 0.125331324646704 0.452449339454099 no 1491 0.450130627106313 2202 6769098
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.125132711936518 0.45252759476032 no 1492 0.450209243219787 2126 688761
SGTC_2108 5365811 200 µM 0.125120922003278 0.452532240164721 no 1493 0.450213910045673 2136 780283
SGTC_3124 9127567 49.47 µM 0.124798495976873 0.452659283203862 no 1494 0.450341539060314 2190 17592030
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.123898004501623 0.453014122539665 no 1495 0.450698016476004 2173 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2803 7707263 71.43 µM 0.122864349637215 0.453421481246784 no 1496 0.451107258275447 2084 2199229
SGTC_3321 9137793 26.8275 µM 0.122392789975564 0.453607337083602 no 1497 0.45129397417437 2198 4904192
SGTC_2719 novobiocin 32.65 µM 0.122377391153291 0.45361340639386 no 1498 0.451300071580415 2165 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2255 7941087 197.44 µM 0.121985480383041 0.453767878217099 no 1499 0.451455258681982 2196 935561
SGTC_1943 st076331 65.2 µM 0.121884890964722 0.453807526714808 no 1500 0.451495090834488 2218 24208415
SGTC_973 1325-0077 65.9 µM 0.120577358914899 0.454322947534115 no 1501 0.452012901472485 2138 2835149
SGTC_2943 9068529 45.32 µM 0.119664951224844 0.454682658464208 no 1502 0.452374282834577 2195 3270634
SGTC_818 4072-2707 53.5 µM 0.118852523002524 0.455002984414303 no 1503 0.452696098104503 2175 882871
SGTC_3072 9116419 49.47 µM 0.118209581729045 0.455256505436215 no 1504 0.452950799034322 2090 17170162
SGTC_2858 9025781 8.96 µM 0.11695095514755 0.455752852719681 no 1505 0.453449459399295 2188 4894980 YPL153C RAD53
SGTC_2652 actinonin 100 µM 0.116774816258664 0.455822319721553 no 1506 0.453519250452482 2203 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1065 prochlorperazine maleate 2.48 µM 0.116156590673439 0.456066150930313 no 1507 0.453764219713278 2199 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2695 st077686 51.995 µM 0.114412544204552 0.456754100311569 no 1508 0.454455385228529 2094 2876092
SGTC_2060 5238662 140 µM 0.114063298176409 0.456891878105184 no 1509 0.454593808051576 2112 790130
SGTC_1749 st037932 54.2 µM 0.113975905866747 0.456926355241526 no 1510 0.45462844664649 2109 594497
SGTC_1385 3091-4834 14.1 µM 0.113027109016837 0.457300685859721 no 1511 0.455004531518682 2143 4072814
SGTC_660 4031-1742 102 µM 0.112885278326373 0.457356645853709 no 1512 0.455060753957288 2116 6738706
SGTC_1926 methyl fluorone black 53.6 µM 0.112784697891872 0.457396330869517 no 1513 0.455100625121046 2186 72721 Reacts with homocysteine.
SGTC_1190 1486-1332 13 µM 0.111901868153013 0.457744678352427 no 1514 0.455450607668527 2188 4150046
SGTC_3141 9094609 49.47 µM 0.111486181412452 0.457908711531032 no 1515 0.455615411461231 2007 25236309 YDL196W YDL196W
SGTC_419 nsc-638432 893 µM 0.111395655539534 0.457944434686989 no 1516 0.455651302499206 2095 368090
SGTC_2683 piperine 63.03 µM 0.111154533571652 0.458039587457897 no 1517 0.455746902543878 2136 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1983 st071813 46.9 µM 0.110566870126228 0.458271504242029 no 1518 0.455979910084745 2086 11838595
SGTC_3128 9127691 49.47 µM 0.110514015348693 0.45829236366423 no 1519 0.456000867656015 2131 41316314
SGTC_1603 st002045 67.8 µM 0.109940116968741 0.458518863128708 no 1520 0.456228433311527 2224 5887985
SGTC_3167 9103034 49.47 µM 0.109911380173849 0.458530204983725 no 1521 0.456239828577292 2200 5127859
SGTC_250 brefeldin a 552.239 µM 0.109591730761248 0.458656366675169 no 1522 0.456366584525521 2164 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1256 0570-0116 285 µM 0.109316618377854 0.458764953484136 no 1523 0.456475683013815 2108 410638
SGTC_3249 9135183 49.47 µM 0.109196591636362 0.458812328982243 no 1524 0.456523281812683 2155 4902779
SGTC_282 k297-0036 65.7 µM 0.109127336665712 0.458839664729599 no 1525 0.456550746421403 2178 5061378
SGTC_348 k064-0012 10.7 µM 0.10902185638378 0.458881299405163 no 1526 0.45659257738691 2198 5066323
SGTC_1633 st005664 67.9 µM 0.108838421535953 0.458953705010451 no 1527 0.45666532442048 2168 2063822
SGTC_537 1334-0398 209 µM 0.107522688400052 0.459473092412237 no 1528 0.457187163459688 2246 5846986
SGTC_3042 9091578 49.47 µM 0.106616723098922 0.459830763685934 no 1529 0.457546525546437 2201 25236497
SGTC_903 1134-0042 114 µM 0.105867103972502 0.460126734741865 no 1530 0.457843897289909 2083 701009
SGTC_2957 9076800 11.52 µM 0.105364835911188 0.460325056899641 no 1531 0.458043158794145 2122 16459615
SGTC_1859 st055998 20 µM 0.103434543359062 0.461087330541779 no 1532 0.458809048764403 2233 676301
SGTC_2036 5160441 105 µM 0.103400574200541 0.461100746270631 no 1533 0.458822528222196 2141 134534 YIL048W NEO1
SGTC_1915 st067105 30.6 µM 0.10296277056802 0.461273655741642 no 1534 0.458996259324082 2203 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1390 3413-2614 145 µM 0.102378244869444 0.461504524139766 no 1535 0.459228225503541 2118 3421432
SGTC_2764 methyldopa 94.69 µM 0.102131911326541 0.46160182166569 no 1536 0.459325985933824 2202 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_184 1494-0393 24.714 µM 0.102113780113972 0.461608983274662 no 1537 0.459333181620929 2151 3090647
SGTC_3033 9090887 49.47 µM 0.101052535077499 0.462028183798733 no 1538 0.459754378306813 2151 19325384
SGTC_3237 9133362 49.47 µM 0.100732650426678 0.462154549163981 no 1539 0.459881345949191 2231 43845137
SGTC_2386 9075165 157.42 µM 0.100037652581415 0.462429110205023 no 1540 0.460157216463001 2140 16452277
SGTC_722 3534-0461 190 µM 0.0998982418616174 0.462484186999485 no 1541 0.460212556080676 2128 658262
SGTC_2160 5660466 132.927 µM 0.099542786948991 0.462624619317996 no 1542 0.460353658751071 2234 2859134
SGTC_1916 st067606 49.2 µM 0.0992591906742369 0.462736665231294 no 1543 0.460466239737745 2192 19590279
SGTC_619 1652-1634 108 µM 0.0981474105334415 0.463175946334894 no 1544 0.460907620533444 2131 5400454
SGTC_1721 st082152 9.2685 µM 0.0958827548293801 0.46407088429542 no 1545 0.461806845560474 2238 5296051
SGTC_1 0258-0098 57.368 µM 0.0939481821849576 0.464835525475265 no 1546 0.462575159607264 2135 6790032 YDR047W HEM12
SGTC_2154 5570129 200 µM 0.0938635303549631 0.4648689871561 no 1547 0.46260878222671 2236 673366
SGTC_1505 k297-0037 20.6 µM 0.0912417630778007 0.465905456816404 no 1548 0.463650245596306 2103 4089396
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0910381826740671 0.465985948522569 no 1549 0.463731125812598 2241 77254
SGTC_531 3788-1495 174 µM 0.0900718352982079 0.466368042278979 no 1550 0.464115065200179 2123 2896655
SGTC_2830 7992007 71.43 µM 0.0896340865161075 0.466541138372488 no 1551 0.464288998148517 2197 1952075
SGTC_754 3474-0146 171 µM 0.0895282968589692 0.466582971024769 no 1552 0.464331033115848 2128 24762078
SGTC_3008 9078912 71.4286 µM 0.0894010071393572 0.466633305986474 no 1553 0.464381611548299 2188 16648731
SGTC_190 3970-0790 3.722 µM 0.0881483947884989 0.467128662580914 no 1554 0.464879366284634 2259 2832352
SGTC_1111 tnp00062 510.699 nM 0.0880072414841971 0.467184486105379 no 1555 0.464935460302825 2228 676306
SGTC_1365 1672-3266 55.4 µM 0.0868580339891117 0.467639000363915 no 1556 0.465392178711865 2238 6415873
SGTC_707 0865-0008 204 µM 0.0862051757673744 0.467897226152578 no 1557 0.465651658179643 2192 723043
SGTC_3320 9137005 35.139 µM 0.0855540649537938 0.468154774241719 no 1558 0.465910457682829 2093 4908713
SGTC_1417 3966-0327 90.4 µM 0.0835072515890007 0.468964481374393 no 1559 0.466724105799878 2187 651118
SGTC_2714 st079313 56.9 µM 0.0831120562356304 0.469120833184745 no 1560 0.466881219762603 2216 2939799
SGTC_1828 st055811 49 µM 0.0830937019095326 0.469128094853929 no 1561 0.466888516838632 2270 5877589
SGTC_2982 9019404 25.97 µM 0.0822792211067899 0.46945034472793 no 1562 0.467212338770682 2111 22333232
SGTC_87 0100-0052 35.5 µM 0.0821605128682397 0.469497313397786 no 1563 0.467259536704596 2247 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1353 1498-1206 8.11 µM 0.0812205683541395 0.469869231276658 no 1564 0.46763327118655 2242 6756808
SGTC_713 1488-1073 324 µM 0.0804039943596426 0.470192355176115 no 1565 0.467957975076473 2273 3312542
SGTC_2229 7354935 190 µM 0.0801350397542624 0.470298786655621 no 1566 0.468064927327015 2258 318112
SGTC_607 4491-0986 66.8 µM 0.0800627494051394 0.47032739395979 no 1567 0.468093674636697 2267 698981 YDR232W HEM1
SGTC_1776 st049249 45.9 µM 0.0785103974816498 0.470941739554291 no 1568 0.468711029879567 2177 1822314
SGTC_1690 st023502 41.2 µM 0.0780564078681933 0.471121419758309 no 1569 0.468891591414354 2280 24207482
SGTC_334 1502-1024 68.5 µM 0.0780370735107459 0.471129072049368 no 1570 0.468899281250777 2183 3296216
SGTC_977 1348-1378 135 µM 0.0776618565087717 0.471277580240616 no 1571 0.469048518262059 2268 X977
SGTC_3300 9124615 50.48 µM 0.0776045815948581 0.471300249591568 no 1572 0.469071298894795 2237 24824903
SGTC_867 0518-0118 155 µM 0.077360930263806 0.471396687571597 no 1573 0.469168210367364 2284 6848158
SGTC_570 0987-0065 62.6 µM 0.0773426243701399 0.471403933170963 no 1574 0.46917549154698 2279 3104428
SGTC_2473 5854593 8.94 µM 0.0752648607305337 0.472226387318158 no 1575 0.470001989613926 2182 2872951
SGTC_2558 carylophyllene oxide 100 µM 0.0749158504966162 0.472364549930545 no 1576 0.47014083256227 2292 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2824 7998404 51.95 µM 0.0740556044888129 0.472705109512448 no 1577 0.470483070348985 2227 837851
SGTC_999 SEC7.066 22.7 µM 0.0737680797860258 0.472818941055612 no 1578 0.4705974632202 2214 740511 YDR170C SEC7
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.073570033473071 0.472897349236166 no 1579 0.47067625816223 2256 4620898
SGTC_1057 3448-5381 134 µM 0.0724306829799285 0.473348447867428 no 1580 0.471129583713234 2257 5497911
SGTC_2249 haloperidol 116.36 µM 0.0713540573152543 0.473774743519082 no 1581 0.471557986655585 2239 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1655 st012546 55.1 µM 0.0703635005217952 0.474166986283333 no 1582 0.471952170789666 2242 720985 YLR208W SEC13
SGTC_354 2783-3500 4.88 µM 0.0699092277383192 0.474346878575604 no 1583 0.472132954214277 2195 6740761
SGTC_622 1348-1566 26.3 µM 0.0698192314113899 0.474382517796492 no 1584 0.472168770038701 2233 7340407
SGTC_2811 7967822 32.47 µM 0.0684864245664939 0.474910343156084 no 1585 0.472699213164403 2249 2232244
SGTC_1460 k062-0059 9.15 µM 0.0681194178488601 0.475055694909268 no 1586 0.472845286525496 2255 1373085
SGTC_2452 5863136 48.41 µM 0.0662867700387589 0.475781558092587 no 1587 0.473574758018994 2272 2184096
SGTC_3018 9082602 49.47 µM 0.0662223077234945 0.475807091383155 no 1588 0.473600418380008 2213 17332089
SGTC_129 0088-0017 176.636 µM 0.0652840779907134 0.476178731988366 no 1589 0.473973909610785 2298 182446
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0639984976614163 0.476687994641858 no 1590 0.474485711524899 2311 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2208 7283366 200 µM 0.0639027974035955 0.476725906343619 no 1591 0.47452381241394 2276 898663
SGTC_2212 7123476 200 µM 0.0610660732211524 0.477849770136653 no 1592 0.475653294176166 2268 1085715
SGTC_3304 9125678 46.087 µM 0.0608630361811356 0.477930216958006 no 1593 0.475734143850028 2265 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2093 5331342 194.4 µM 0.0605594607999577 0.478050500502498 no 1594 0.475855029914697 2298 33839
SGTC_636 0kpi-0074 126 µM 0.0601529591553621 0.478211568927815 no 1595 0.476016905491971 2227 616434
SGTC_2190 6049624 200 µM 0.0598765891820216 0.478321077225663 no 1596 0.476126962779754 2275 2265554
SGTC_135 0933-0004 26.348 µM 0.0588486579242974 0.478728396996602 no 1597 0.476536326084019 2224 21230617 YGL099W LSG1
SGTC_2774 tamoxifen 10.92 µM 0.0581842014848677 0.478991701009104 no 1598 0.476800952395195 2290 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_641 4092-0595 30 µM 0.0544011010954852 0.480491000686268 no 1599 0.478307800804188 2276 786260
SGTC_1363 1636-0063 10.4 µM 0.0537807360155475 0.480736887620656 no 1600 0.478554928868293 2309 6072185
SGTC_3152 9099253 49.47 µM 0.0534198872485272 0.480879916452034 no 1601 0.478698680051021 2266 25236131
SGTC_91 0417-1751 58.384 µM 0.0527236963453513 0.481155871047084 no 1602 0.478976029163922 2314 6795624
SGTC_337 1315-0038 354 µM 0.0521296785863099 0.48139133362405 no 1603 0.479212682508589 2255 1626437
SGTC_1067 clotrimazole 1.36 µM 0.0519538321689094 0.481461038598235 no 1604 0.479282740144893 2250 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1195 1502-0147 41.1 µM 0.0506462938422619 0.481979360366258 no 1605 0.479803686492051 2307 817940
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0498708375277304 0.482286773746861 no 1606 0.480112658328671 2295 688664
SGTC_446 go6976 132 µM 0.0492489564063363 0.482533313083889 no 1607 0.480360448501401 2302 3501 A protein kinase C inhibitor.
SGTC_2367 9070478 135.38 µM 0.0482367622428817 0.482934602857098 no 1608 0.480763776121027 2306 572802
SGTC_1771 st048882 4.1505 µM 0.0482052791493178 0.48294708477675 no 1609 0.48077632146405 2285 4580403
SGTC_1651 st011928 86.1 µM 0.0479586728508094 0.483044855923996 no 1610 0.480874589485451 2292 720198
SGTC_1974 st069448 26.9 µM 0.04731096953814 0.483301653459408 no 1611 0.481132692723393 2323 6323587 YNR016C ACC1
SGTC_2244 6635614 200 µM 0.0458536263931853 0.48387947731854 no 1612 0.481713458023333 2231 836499
SGTC_2649 anisomycin 9.56 µM 0.0454013726103822 0.484058798943243 no 1613 0.481893693466285 2279 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2502 avocadyne acetate 18.59 µM 0.0453398026913757 0.484083212074691 no 1614 0.481918231041993 2326 3952079
SGTC_368 fentichlor 4.58 µM 0.0451415494470343 0.484161822011555 no 1615 0.481997241745526 2268 7329 A pesticide.
SGTC_2523 spermine 47.74 µM 0.0442233238764742 0.484525918127469 no 1616 0.482363195236565 2325 1103 A DNA binding polyamine.
SGTC_1624 st003710 6.25 µM 0.0442022133497691 0.484534289056585 no 1617 0.482371608890834 2313 24207033
SGTC_3305 9127027 53.8275 µM 0.0427520628660728 0.485109331418497 no 1618 0.482949588656441 2261 41905295
SGTC_1866 st057638 64 µM 0.0416474606102488 0.485547371002639 no 1619 0.483389868972395 2295 688802
SGTC_1043 0916-0009 19.3 µM 0.0411879755819047 0.485729588933639 no 1620 0.483573019817428 2339 3101130
SGTC_115 0527-0192 112.043 µM 0.0411275841317179 0.485753538587275 no 1621 0.483597092122846 2205 4233931
SGTC_1611 st001856 99.4 µM 0.0390110861261321 0.486592917619384 no 1622 0.484440774946225 2310 647478
SGTC_1091 telmisartan 47.6 µM 0.0375675483888363 0.487165442563091 no 1623 0.485016241141026 2306 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1468 k284-1086 134 µM 0.0364230787731308 0.487619372243716 no 1624 0.485472506093372 2325 15996457
SGTC_2844 9010103 25.97 µM 0.036415886950164 0.4876222247796 no 1625 0.485475373313486 2286 2480525
SGTC_2487 5918373 44.05 µM 0.0362806272182738 0.487675873776202 no 1626 0.485529298504695 2353 2876279
SGTC_2072 5231554 129 µM 0.0362666717715976 0.48768140903359 no 1627 0.485534862260879 2344 789545
SGTC_1040 k898-0338 155 µM 0.0347246012882594 0.488293066825326 no 1628 0.486149671881458 2345 20969351
SGTC_2327 6189656 200 µM 0.0344017671580239 0.488421121582037 no 1629 0.486278387159524 2334 5349088
SGTC_2744 captopril 92.04 µM 0.033350409490939 0.488838159269382 no 1630 0.486697577567207 2339 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_103 0844-0104 51.839 µM 0.033330906580171 0.488845895524848 no 1631 0.486705353779684 2349 5375804
SGTC_2115 tiliquinol 12.7705 µM 0.0329298467152399 0.48900498560503 no 1632 0.486865265730194 2309 71208 A bioactive hydroxyquinoline.
SGTC_1123 mangostin 811.285 nM 0.0328323629791634 0.489043655148223 no 1633 0.486904135096331 2247 5281650 An antioxidant.
SGTC_2405 ticlatone 3.52 µM 0.0321486878144117 0.489314856145437 no 1634 0.487176738097795 2368 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2381 9035592 200 µM 0.0314970387563506 0.489573357592781 no 1635 0.487436576852473 2208 4749657
SGTC_518 1021-0119 62.6 µM 0.0312079738158604 0.489688027632732 no 1636 0.487551840413824 2219 1097762
SGTC_306 1672-3436 11.6 µM 0.0311514351552876 0.489710456223864 no 1637 0.487574385114651 2324 6797378
SGTC_501 nsc-95397 161 µM 0.0297966199423036 0.490247913906424 no 1638 0.488114627233354 2333 262093
SGTC_922 1866-0035 480 µM 0.0297945176395994 0.490248747907779 no 1639 0.488115465558584 2274 3156169
SGTC_2122 5258151 111.688 µM 0.0282545440429983 0.490859679740095 no 1640 0.488729567354971 2319 2173356
SGTC_2835 9006588 71.43 µM 0.0279666176105739 0.490973907122903 no 1641 0.488844388007238 2275 2345538
SGTC_1694 st024011 44.9 µM 0.0277568588581547 0.491057123962206 no 1642 0.48892803716837 2361 2787533
SGTC_1296 1068-0102 11.9 µM 0.0274780262770899 0.4911677448164 no 1643 0.4890392328599 2343 767053
SGTC_339 3091-4833 71.4 µM 0.0269125914120223 0.491392071064589 no 1644 0.489264725330562 2336 3240077
SGTC_3058 9093861 49.47 µM 0.0261728671543921 0.491685547635947 no 1645 0.489559728670384 2337 17217477
SGTC_1275 0867-0008 21.1 µM 0.0258109488479109 0.491829135956653 no 1646 0.489704064420746 2330 3422836
SGTC_1223 0764-0573 147 µM 0.0251949524211237 0.492073530253447 no 1647 0.489949731532088 2359 1609797
SGTC_1782 st039423 80.636 µM 0.0244711907056304 0.492360683823728 no 1648 0.490238381658725 2335 2068169
SGTC_927 2425-1185 123 µM 0.0237749204720301 0.492636933844393 no 1649 0.490516072478957 2366 730375
SGTC_1573 oleylamine 1.06 µM 0.0232214833145967 0.492856516381811 no 1650 0.490736801010034 2341 5356789 An amine of the fatty acid oleic acid.
SGTC_655 k060-0012 42 µM 0.0225387296727145 0.493127409692318 no 1651 0.491009109013742 2356 5994525
SGTC_2287 7945887 168.79 µM 0.0218416099949336 0.493404006224191 no 1652 0.491287151059195 2349 1245853
SGTC_1389 3405-0187 19 µM 0.0209001307887914 0.493777562420296 no 1653 0.491662661146611 2360 799890
SGTC_1075 aripiprazole 15.2 µM 0.0197236560928081 0.494244366778962 no 1654 0.492131909807952 2371 60795 An atypical antipschotic. YIL048W NEO1
SGTC_586 0957-0265 8.15 µM 0.019655451103624 0.494271429560632 no 1655 0.49215911438804 2368 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2397 5161689 200 µM 0.0195066118289837 0.494330486985518 no 1656 0.4922184812854 2350 2259942
SGTC_1868 st057644 42.7 µM 0.0183610752309745 0.494785024581967 no 1657 0.492675402334862 2374 688665
SGTC_2601 securinine 100 µM 0.0172176277152852 0.495238740003663 no 1658 0.493131499695217 2356 442872 A GABA receptor antagonist.
SGTC_2742 clothiapine 36.27 µM 0.0170212375015446 0.495316667494632 no 1659 0.493209836574679 2378 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2455 5377712 9.75 µM 0.0167462295843987 0.495425790731609 no 1660 0.493319533223725 2332 2243908
SGTC_1039 k821-0043 94 µM 0.0151232215571356 0.496069807579072 no 1661 0.493966937477985 2355 15992768
SGTC_2816 7982706 58.44 µM 0.0139721007497765 0.496526583773468 no 1662 0.494426119620591 2360 2981853
SGTC_1253 0550-0034 176 µM 0.0139200754589568 0.496547228038771 no 1663 0.494446872690482 2355 5969915
SGTC_1837 st055472 66.5 µM 0.0133601058966803 0.496769431314992 no 1664 0.494670247441059 2353 676091
SGTC_1391 3442-0225 151 µM 0.0119944122808308 0.497311360541311 no 1665 0.495215036545085 2383 5227075
SGTC_489 paxilline 115 µM 0.0105859210077731 0.497870277753663 no 1666 0.495776907407663 2366 105008 A toxic potassium channel blocker.
SGTC_1693 xanthone 101.9 µM 0.0101527359492557 0.498042175049426 no 1667 0.495949713950806 2374 7020 An insecticide.
SGTC_735 3076-0345 636 µM 0.00953704068694387 0.498286496999439 no 1668 0.496195328915892 2390 2888990
SGTC_432 NS 1619 61.3 µM 0.00923512461337076 0.498406304437381 no 1669 0.496315770696826 2324 4552 A K+/calcium channel activator.
SGTC_279 1273-0055 2.93 µM 0.00920726295706406 0.498417360608906 no 1670 0.496326885416973 2377 2847562
SGTC_2126 5251174 33.877 µM 0.00915598919816631 0.498437707265804 no 1671 0.496347339825076 2379 790722
SGTC_2459 5811157 9.22 µM 0.00904109827040356 0.498483298755302 no 1672 0.496393172776625 2391 2870684 YBR192W RIM2
SGTC_1317 1273-0028 910 nM 0.00647474801083851 0.49950169245747 no 1673 0.497416967311349 2394 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1563 conessine 56.1 µM 0.00574646317027571 0.499790695469008 no 1674 0.497707505495678 2396 441082 An anti-amoebic, histamine inhibitor.
SGTC_2009 4012297 12.05 µM 0.00531158680601411 0.499963266168186 no 1675 0.497880993410969 2385 45595307
SGTC_1981 st071826 47 µM 0.00512644906896505 0.499963266168186 no 1676 0.497954851675982 2367 11838600
SGTC_444 curcumin 90.4 µM 0.0050499934215121 0.499932926498715 no 1677 0.497985352671482 2390 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3306 9127676 59.7925 µM 0.00463847044082964 0.499769623057002 no 1678 0.498149524660385 2391 41905287
SGTC_1936 st074407 74.3 µM 0.00364378221985232 0.499374904098468 no 1679 0.49854634442866 2397 809813
SGTC_3324 9138759 60.749 µM 0.00260225600252102 0.498961599229358 no 1680 0.498961851227844 2395 45595710
SGTC_1860 st056228 74.6 µM 0.00136319673505555 0.498469909562897 no 1681 0.499456163354317 2399 688679
SGTC_1272 0839-0021 27 µM 0.000725116614931615 0.498216704292858 no 1682 0.499710720349432 2405 5027250
SGTC_226 1,3-diallylurea 8.28947 mM 0.000388432476992198 0.498083100353851 no 1683 0.499845037865744 2401 74537 YKL182W FAS1
SGTC_2158 5657123 3.6195 µM 0 0.49792896176261 no 1684 0.5 2405 2858827
SGTC_2801 7907800 81.82 µM 0 0.49792896176261 no 1685 0.5 2406 6620925
SGTC_1735 st034310 56.75 µM -0.000553200863581965 0.497709439973504 no 1686 0.499779304797219 2414 871153
SGTC_1261 0712-0010 12.7 µM -0.000944337467582533 0.497554229120858 no 1687 0.499623263913208 2409 2840123
SGTC_923 1900-2434 73.3 µM -0.00114113061494759 0.497476137789837 no 1688 0.499544754849039 2407 5910570
SGTC_1350 1495-0454 146 µM -0.00167390006380319 0.497264725051337 no 1689 0.499332210803233 2412 1069057
SGTC_610 4215-0184 155 µM -0.00234404512265009 0.496998800236438 no 1690 0.499064862149766 2410 5605015
SGTC_1029 k015-0030 64.7 µM -0.00244987675421316 0.496956804586414 no 1691 0.499022641558639 2424 2208316
SGTC_3224 9130643 49.47 µM -0.00332417440288165 0.496609870910381 no 1692 0.498673848725621 2419 17644395
SGTC_3334 9142812 21.919 µM -0.0040635159318539 0.496316491722214 no 1693 0.498378896149021 2430 45283678
SGTC_452 diindolylmethane 8 µM -0.00429745466920799 0.496223662558734 no 1694 0.498285568911398 2418 3071 Inhibits expression of several cancer promoting factors.
SGTC_38 0929-0051 58.268 µM -0.00449205585062133 0.496146443075156 no 1695 0.498207935022148 2419 1379719
SGTC_2380 9035439 200 µM -0.00501014997668212 0.495940859419051 no 1696 0.498001247705134 2451 6462575
SGTC_2095 5432005 200 µM -0.00589864867812567 0.4955882989741 no 1697 0.497646793291337 2420 783734
SGTC_2163 5671233 125 µM -0.00623746375412014 0.495453856458083 no 1698 0.497511628121434 2416 701023
SGTC_3354 9151612 71.43 µM -0.00691710303015866 0.495184175773616 no 1699 0.497240497148735 2418 27261949
SGTC_868 0527-0199 213 µM -0.00697720778066204 0.49516032632868 no 1700 0.497216519401135 2432 2849450
SGTC_2711 st079103 59.1 µM -0.00756613973823175 0.494926640232699 no 1701 0.496981575758044 2424 54693780
SGTC_2432 5630864 12.22 µM -0.00894959389534564 0.494377697557595 no 1702 0.496429676263772 2441 5714970
SGTC_2409 alverine citrate 63.97 µM -0.00919240881196866 0.494281351762129 no 1703 0.496332811112719 2484 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2875 9039966 71.43 µM -0.00949712185371542 0.494160446069682 no 1704 0.49621125350505 2472 6463691
SGTC_2317 5986382 200 µM -0.011049918851016 0.493544327427371 no 1705 0.495591809882695 2437 877883
SGTC_883 0850-0245 24.6 µM -0.0110899606021927 0.493528439862579 no 1706 0.495575836513918 2499 6823229 YPR165W RHO1
SGTC_427 1354-0053 47.3 µM -0.0115987455540239 0.493326567628893 no 1707 0.49537287374769 2487 6813657
SGTC_1280 0880-0253 10.1 µM -0.0118493334610319 0.493227141687987 no 1708 0.495272910507253 2431 6836607
SGTC_211 3455-0679 143.504 µM -0.012844484564337 0.492832299095374 no 1709 0.494875932933143 2435 748649
SGTC_1747 st037496 66.6 µM -0.0132099629300133 0.492687291276201 no 1710 0.494730140532948 2441 723305
SGTC_3059 1327-0034 3 µM -0.0133258272425185 0.492641320954956 no 1711 0.494683921428242 2436 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2730 imipramine 71.33 µM -0.0137122842468416 0.492487990995263 no 1712 0.494529761478775 2435 3696 A tricyclic antidepressant.
SGTC_2997 9067075 71.4286 µM -0.0140382487766856 0.492358662778821 no 1713 0.494399732963828 2443 27209819
SGTC_2165 5727197 32.143 µM -0.014215566618228 0.492288311288333 no 1714 0.49432900043824 2492 1361712
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0149756326566352 0.491986755102685 no 1715 0.494025810263173 2451 6708739 YPR165W RHO1
SGTC_3283 9109332 35.8195 µM -0.0154047110744875 0.491816520260307 no 1716 0.493854652489721 2426 17027281
SGTC_1041 0206-0046 107 µM -0.0156281599925814 0.491727868542197 no 1717 0.493765519999374 2483 50494
SGTC_385 1494-0393 12.4 µM -0.0160154777882665 0.491574204020202 no 1718 0.493611021894651 2453 3090647
SGTC_2768 sulfasalazine 50.2 µM -0.0161518429724679 0.491520102772445 no 1719 0.493556627093131 2440 5384001 An antioxidant and salicylic acid derivative.
SGTC_1662 st014054 52 µM -0.0168862780340075 0.491228727197073 no 1720 0.493263669875173 2432 2838777
SGTC_2676 harmalol 100 µM -0.0169408275865377 0.491207085703694 no 1721 0.493241910864798 2432 5459187 A monoamine oxidase inhibitor
SGTC_3174 9107204 49.47 µM -0.0170929774898308 0.491146723271744 no 1722 0.493181220623298 2442 3938802
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0182320300848167 0.490694833465088 no 1723 0.492726875283347 2464 521171
SGTC_1129 3453-1384 223 µM -0.0183349055041854 0.490654020869054 no 1724 0.49268584078815 2507 1084452
SGTC_520 3584-0023 682 µM -0.0184726678372856 0.490599368137517 no 1725 0.492630890875411 2488 1340790
SGTC_682 0kpi-0099 17 µM -0.0195148153120224 0.490185935763065 no 1726 0.492215209192019 2474 1714895 YML126C ERG13
SGTC_52 0329-0193 875 nM -0.0196003586529576 0.490152000158262 no 1727 0.492181088862647 2487 3739292
SGTC_214 4373-3496 70 µM -0.0213169143373134 0.489471046649459 no 1728 0.49149642560742 2458 3779166
SGTC_832 4083-0019 164 µM -0.0218675559961481 0.489252614834683 no 1729 0.491276802573935 2483 1990758
SGTC_1333 1482-0047 286 µM -0.0222957848386248 0.489082744690251 no 1730 0.491106005629674 2450 3811116
SGTC_2441 5730946 39.09 µM -0.0224909123764596 0.489005342004366 no 1731 0.491028180520501 2472 1774275
SGTC_68 0986-0284 82.829 µM -0.0228096007413827 0.488878926421643 no 1732 0.490901074866949 2579 423278 YIL048W NEO1
SGTC_3353 9151644 39.2805 µM -0.0229752769662161 0.48881320731043 no 1733 0.490834996932875 2489 4909158
SGTC_2138 5575593 77.673 µM -0.0232561676894 0.48870178653442 no 1734 0.490722967682257 2448 762213
SGTC_1411 3909-8223 150 µM -0.0241748324196115 0.488337386480867 no 1735 0.490356576540989 2452 X1411
SGTC_2256 7954252 200 µM -0.0259149315610537 0.487647180950901 no 1736 0.489662595191592 2496 2972920
SGTC_164 4100-3994 89.624 µM -0.0260060818238451 0.487611027452054 no 1737 0.48962624374946 2442 4615967
SGTC_1328 1441-0025 69.2 µM -0.0263065672198244 0.487491844772647 no 1738 0.489506408420693 2450 4562601
SGTC_541 4513-1321 94 µM -0.0277319776003215 0.486926494164759 no 1739 0.48893795953449 2472 747515
SGTC_2076 5212012 200 µM -0.0278901013818886 0.486863780226904 no 1740 0.488874901663446 2455 604802
SGTC_3288 9119690 36.221 µM -0.0278921740864823 0.486862958167596 no 1741 0.488874075095512 2491 17595618 YKL019W RAM2
SGTC_3344 9148862 3.898 µM -0.0280208773740934 0.486811913021555 no 1742 0.488822749973431 2486 4905352
SGTC_2575 plumbagin 510 nM -0.0287368027756215 0.486527973063266 no 1743 0.48853725205449 2452 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3023 9089636 49.47 µM -0.0308245277224096 0.485700009368327 no 1744 0.487704739708971 2453 17249241
SGTC_2909 7941780 10.49 µM -0.0311984864413557 0.485551708765832 no 1745 0.487555623486517 2458 1243215
SGTC_451 chloral hydrate 100 µM -0.0316860949343493 0.485358341139879 no 1746 0.487361191977272 2502 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2363 9053361 176 µM -0.0318150297021459 0.485307210918449 no 1747 0.487309780367528 2478 6469797 YMR079W SEC14
SGTC_1324 1418-0026 34.4 µM -0.0330794239048824 0.484805817155472 no 1748 0.486805625557163 2529 1372513
SGTC_961 1252-1571 372 µM -0.0332945126272291 0.484720526390721 no 1749 0.486719864812317 2473 6813498
SGTC_657 3534-0529 86.7 µM -0.0333239500165626 0.484708853413438 no 1750 0.486708127506193 2475 1049549
SGTC_3156 9099931 49.47 µM -0.0334093947233432 0.484674971606731 no 1751 0.486674058970156 2469 18111053
SGTC_2074 5212007 75.395 µM -0.0346696805751409 0.484175237287395 no 1752 0.486171568891207 2459 758611
SGTC_3131 9127911 49.47 µM -0.0357834882296789 0.483733605839002 no 1753 0.485727499559547 2541 45595681
SGTC_3160 9100216 49.47 µM -0.0359255930555716 0.483677261843086 no 1754 0.485670844364492 2467 17191039
SGTC_2986 9022445 71.43 µM -0.0371600561856741 0.483187815977926 no 1755 0.485178693572931 2456 6459286
SGTC_2561 acetosyringone 100 µM -0.037335170236953 0.483118387953329 no 1756 0.485108881618891 2454 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1245 0418-0076 17.2 µM -0.0376439580348721 0.482995963121924 no 1757 0.484985779649425 2529 6790114
SGTC_1881 5652484 16 µM -0.0432136517125228 0.480788037978092 no 1758 0.482765611380986 2472 2255129
SGTC_2068 5226020 147 µM -0.0432759020089706 0.480763364062533 no 1759 0.482740800316338 2505 1810509
SGTC_1619 st003326 88.7 µM -0.0435783060870105 0.480643502347352 no 1760 0.482620272250647 2482 2849032
SGTC_2834 9001755 58.44 µM -0.0436261751567914 0.480624528990864 no 1761 0.482601193399343 2601 2989575
SGTC_62 0180-0423 3.232 µM -0.0442076996967682 0.480394039782745 no 1762 0.482369422292487 2512 30102 YGL099W LSG1
SGTC_996 3970-0799 1.8 µM -0.0454680329537744 0.479894525055714 no 1763 0.481867127271501 2460 6615648 YGL040C HEM2
SGTC_2349 9023730 187.07 µM -0.0457868526854866 0.479768170471856 no 1764 0.481740068929158 2513 4126287
SGTC_144 4161-2749 112.381 µM -0.0464833827626873 0.479492128875604 no 1765 0.481462489201801 2475 797501 YMR168C CEP3
SGTC_1960 st011366 51.8 µM -0.046883563713151 0.479333537740514 no 1766 0.481303013972531 2495 3972846
SGTC_1879 gemcitabine 100 µM -0.047474533312809 0.479099343328656 no 1767 0.481067513458016 2499 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1520 flindersine 88 µM -0.048788940789287 0.478578484849824 no 1768 0.480543747825668 2612 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1484 3473-2379 286 µM -0.0488806416700718 0.478542148020279 no 1769 0.480507208063858 2486 671917
SGTC_3183 9108214 49.47 µM -0.0491180994027449 0.478448055302717 no 1770 0.480412589789235 2484 4974831
SGTC_258 haloperidol 50.781 µM -0.0495460145180465 0.478278496810604 no 1771 0.480242083960811 2500 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1234 0326-0494 15.5 µM -0.0495858315779015 0.478262719767363 no 1772 0.480226218752798 2566 1547813
SGTC_1266 0828-0227 32.9 µM -0.0516967722570212 0.4774263336545 no 1773 0.479385154584145 2548 3913820
SGTC_1042 0350-0096 82 µM -0.0527065984088762 0.477026260434432 no 1774 0.478982840782752 2481 3122515
SGTC_3013 9080133 71.4286 µM -0.053910896501913 0.476549171569491 no 1775 0.478503077569692 2572 17050193
SGTC_1965 Pectolinarigenin 58.4 µM -0.0541613616435037 0.476449952718995 no 1776 0.47840330220879 2513 5320438 An anti-inflammatory.
SGTC_838 0109-0203 71.4 µM -0.0555347558421667 0.475905924708846 no 1777 0.477856220752593 2504 759422
SGTC_165 k038-0023 64.381 µM -0.0557360518953272 0.475826191197647 no 1778 0.477776039434862 2522 46368543
SGTC_1107 amlodipine 47 µM -0.0568279960560628 0.475393688280619 no 1779 0.477341106170396 2537 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3065 9113888 49.47 µM -0.0579930949977232 0.474932241820901 no 1780 0.47687706433256 2583 16648368
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0591232906830198 0.474484651188587 no 1781 0.476426953902711 2584 616764
SGTC_733 4069-0007 56.1 µM -0.0596063172168998 0.474293368307085 no 1782 0.476234593452889 2510 5717425 YNL287W SEC21
SGTC_1338 1486-1223 76 µM -0.0596642182624379 0.474270439365618 no 1783 0.476211535315801 2569 3444526
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0599596655748838 0.474153442908239 no 1784 0.476093879534917 2547 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2988 9073640 71.4286 µM -0.060316462188059 0.474012155241068 no 1785 0.475951795443332 2584 9102229
SGTC_1290 0986-0249 10.2 µM -0.0605775371533731 0.473908774399177 no 1786 0.475847831708625 2517 53329
SGTC_1276 0871-0068 94.2 µM -0.0612380991223783 0.473647211979249 no 1787 0.47558479397166 2574 3414906
SGTC_2075 5212009 200 µM -0.0626470330336744 0.473089355164226 no 1788 0.475023788000208 2537 780898
SGTC_1596 piperlongumine 63 µM -0.0637392456324443 0.472656938034284 no 1789 0.474588927384652 2524 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1628 st004252 77.7 µM -0.0638120815964657 0.472628102738894 no 1790 0.474559929072013 2567 692968
SGTC_3207 9114163 49.47 µM -0.0642749983468528 0.472444840297926 no 1791 0.474375630354946 2550 849233
SGTC_2276 7947513 42.08 µM -0.0653071075305057 0.472036263377555 no 1792 0.473964741718231 2594 2105100
SGTC_292 k038-0015 474 µM -0.0665461265606737 0.471545816789089 no 1793 0.473471517692291 2596 46368540
SGTC_1373 2887-0003 58.5 µM -0.0679121699999226 0.471005139583654 no 1794 0.472927775431019 2591 776948
SGTC_1558 st069300 45.6 µM -0.0682501355819382 0.47087138170373 no 1795 0.472793258778448 2526 24208000
SGTC_2329 6138490 200 µM -0.07045629904996 0.46999832170177 no 1796 0.471915241187032 2757 720019
SGTC_2280 7785178 200 µM -0.0718335126232607 0.46945338049611 no 1797 0.471367201242107 2550 2954328
SGTC_1244 0416-0015 52.5 µM -0.0726169590079847 0.469143408858834 no 1798 0.471055465506391 2566 96201
SGTC_3028 9087778 49.47 µM -0.0728437286304553 0.469053690628275 no 1799 0.470965236474521 2548 17217395
SGTC_3044 9093193 49.47 µM -0.0741989206676349 0.468517560758767 no 1800 0.470426052333979 2610 25236277
SGTC_120 rhodamine 6G 52.259 µM -0.074822646727122 0.468270826537309 no 1801 0.470177911419839 2545 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_507 nimesulide 162 µM -0.0748692124231219 0.468252406517237 no 1802 0.470159386355527 2616 4495 A COX2 inhibitor.
SGTC_2044 5102272 200 µM -0.0750683753118778 0.46817362430234 no 1803 0.470080154825064 2610 592666
SGTC_553 k007-0256 45.7 µM -0.0772700942436639 0.467302781256946 no 1804 0.46920434054735 2592 6287000
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0779011434091495 0.467053211864776 no 1805 0.468953344933956 2565 65057 A dermal irritant. YDR527W RBA50
SGTC_2396 5342950 42.78 µM -0.0781698270903542 0.466946955887523 no 1806 0.46884648152398 2594 1886677
SGTC_1405 3909-7894 12 µM -0.0782519050360448 0.466914497101086 no 1807 0.468813837155816 2614 7104060
SGTC_697 0508-1955 564 µM -0.0788113961392533 0.466693244972433 no 1808 0.468591319718152 2536 6243113
SGTC_2155 5570423 76 µM -0.0796501730907217 0.466361567871611 no 1809 0.468257744794177 2559 797402
SGTC_2014 4013930 200 µM -0.0804177480203963 0.466058066610753 no 1810 0.467952505869994 2540 64556
SGTC_2698 st077697 67.5 µM -0.0804417185952414 0.466048588895742 no 1811 0.467942973875079 2586 3154499
SGTC_94 0334-0113 514.748 µM -0.0805855331204656 0.46599172653857 no 1812 0.467885785840315 2553 6795178
SGTC_2006 4011487 200 µM -0.0814183777456894 0.465662444500242 no 1813 0.467554617151275 2613 45595294
SGTC_1789 tunicamycin 25 nM -0.0815214279655843 0.465621703132483 no 1814 0.467513642269677 2629 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_718 1130-0073 349 µM -0.0817123238901123 0.465546232522724 no 1815 0.467437739043445 2628 6740020
SGTC_197 4544-0043 41.561 µM -0.0817590320634616 0.465527766657979 no 1816 0.467419167318242 2559 896523
SGTC_255 tunicamycin 200.472 nM -0.08189448993646 0.465474214421426 no 1817 0.467365308058228 2575 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1824 st053723 68.6 µM -0.0832940211857881 0.464920957197361 no 1818 0.46680887708937 2578 675225
SGTC_2855 9016525 58.44 µM -0.0833590456965461 0.464895253602058 no 1819 0.466783025964935 2547 43811474
SGTC_1579 chlormadinone acetate 49.4 µM -0.0836440164476618 0.46478260899555 no 1820 0.466669734735161 2590 45114258 A steroidal progestin.
SGTC_426 0988-0037 14.6 µM -0.0841542732327503 0.464580919301082 no 1821 0.466466886919378 2533 5383008
SGTC_2880 9042983 58.44 µM -0.0843849995574772 0.464489722867572 no 1822 0.466375166682051 2666 6464714
SGTC_320 4092-0846 5.34 µM -0.0848635923924846 0.464300561157853 no 1823 0.466184918198437 2648 1359356
SGTC_847 0342-0274 5.54 µM -0.0857040281113857 0.463968402194059 no 1824 0.465850849971707 2633 18097
SGTC_2463 5473429 200 µM -0.0858637582890459 0.463905276093849 no 1825 0.465787360884913 2638 5399405
SGTC_1912 st060209 90.8 µM -0.0860210926807688 0.463843097707582 no 1826 0.465724824919398 2619 688787
SGTC_986 1493-0483 84 µM -0.0860437524190319 0.463834142675553 no 1827 0.465715818384777 2547 40079
SGTC_1452 4194-0072 190 µM -0.0862835668143697 0.463739370172135 no 1828 0.465620500768181 2661 1343545
SGTC_3339 9145883 14.936 µM -0.0865233494722194 0.463644612268317 no 1829 0.465525197738 2595 2030670
SGTC_763 3453-1109 128 µM -0.0890671742658392 0.462639465350493 no 1830 0.464514262411746 2558 1560353
SGTC_2928 9011484 9.79 µM -0.089149018742419 0.462607129893915 no 1831 0.464481740562127 2647 2994751
SGTC_3254 9136651 49.47 µM -0.0900666107438324 0.462244620789901 no 1832 0.464117141058552 2565 16454030
SGTC_2568 diosmetin 100 µM -0.090642303001593 0.462017200529107 no 1833 0.463888408665172 2553 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.090966840612099 0.461889001341308 no 1834 0.463759469570353 2622 1273210
SGTC_2116 5511452 16.8835 µM -0.0910478368056968 0.461857006756721 no 1835 0.46372729030025 2663 870744
SGTC_8 0354-0001 70 µM -0.0914772475322532 0.461687387879032 no 1836 0.463556692131838 2561 4993152
SGTC_2499 avocadenofuran 51.48 µM -0.0922954366329366 0.461364219371558 no 1837 0.463231656967798 2574 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2688 kanamycin b 96.69 µM -0.0923757640839909 0.46133249298939 no 1838 0.463199747270513 2621 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_910 3454-3003 490 µM -0.0926159189535112 0.461237642136889 no 1839 0.463104348305549 2562 820824
SGTC_723 4182-0001 115 µM -0.0928862655324965 0.461130869495153 no 1840 0.462996958544483 2596 744821 YLR208W SEC13
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0931342668250422 0.461032924527049 no 1841 0.462898447372048 2572 3256 An antibiotic and ribosome inhibitor.
SGTC_2226 7298446 200 µM -0.0949532958820604 0.460314594682738 no 1842 0.46217596186069 2593 3283010
SGTC_598 3937-0236 20.2 µM -0.0949798321006108 0.460304116551706 no 1843 0.462165423071276 2635 1379313
SGTC_1081 sertraline 6 µM -0.0952546445867663 0.460195605303765 no 1844 0.462056283578343 2606 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1222 0366-0074 1.18 µM -0.096807466139882 0.459582520957142 no 1845 0.461439647332343 2641 286520
SGTC_2064 5220758 200 µM -0.100004387799159 0.458320617886751 no 1846 0.460170420975299 2708 788518
SGTC_522 1273-0010 11.6 µM -0.10024573301945 0.458225369922725 no 1847 0.460074619574366 2816 5705015
SGTC_2443 5493264 126.67 µM -0.100681161381327 0.45805353225561 no 1848 0.459901783207028 2684 5340055
SGTC_1140 3229-1848 2.98 µM -0.10104716517277 0.457909098398954 no 1849 0.459756509679226 2636 2849525
SGTC_4 0960-0234 25.671 µM -0.10116724605769 0.457861712817522 no 1850 0.459708848572656 2629 6821112
SGTC_186 3455-3465 67.277 µM -0.101783467373636 0.457618552783556 no 1851 0.459464274307622 2577 755278
SGTC_1896 st058441 89 µM -0.10385813059748 0.456800010828647 no 1852 0.458640967149472 2614 688759
SGTC_363 0455-0021 3.06 µM -0.103901483225403 0.456782908335105 no 1853 0.458623765018291 2604 4597466
SGTC_459 nigericin 15.3 µM -0.104711954501282 0.456463194397089 no 1854 0.458302187897013 2693 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_593 1203-0218 61.7 µM -0.105328990897608 0.456219805351274 no 1855 0.458057379754346 2672 3666956
SGTC_2355 9061122 103.12 µM -0.106106480124356 0.455913149335863 no 1856 0.457748934888726 2674 5302957
SGTC_367 0335-0881 7.1 µM -0.106733379138269 0.455665907978344 no 1857 0.457500250565184 2700 23828853
SGTC_807 1315-0151 48 µM -0.10839808277154 0.455009452661209 no 1858 0.456839960951119 2615 4011080
SGTC_532 1548-0774 215 µM -0.10907245527694 0.454743557052277 no 1859 0.456572511011936 2799 5932993
SGTC_2569 tetrandrine 100 µM -0.109660753274305 0.454511615968595 no 1860 0.456339213493252 2666 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1420 4'-methoxyflavone 42 µM -0.110404914554288 0.454218246794272 no 1861 0.456044127853857 2593 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2995 9067767 71.4286 µM -0.110908618151912 0.454019686922253 no 1862 0.455844405735641 2682 11673567
SGTC_462 ag-879 158 µM -0.111255749121023 0.453882854639169 no 1863 0.455706772287634 2649 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2519 cryptotanshinone 88.04 µM -0.111922860074054 0.453619907845445 no 1864 0.455442285382919 2635 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_936 3005-4620 401 µM -0.113186116514213 0.453122041621913 no 1865 0.454941501174302 2633 777207
SGTC_2790 5423970 71.43 µM -0.113381480061954 0.45304505279882 no 1866 0.454864060896835 2720 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_720 r052-1644 49.9 µM -0.11385307644194 0.452859213481272 no 1867 0.454677131589956 2700 1422863 YOR257W CDC31
SGTC_3296 9122258 64.045 µM -0.114611862132995 0.452560224784659 no 1868 0.454376388525083 2703 4730474
SGTC_887 0885-0007 9.62 µM -0.114763253774396 0.452500574277375 no 1869 0.454316387900095 2760 5719458
SGTC_1684 st024538 14.6195 µM -0.115297800452066 0.452289963700687 no 1870 0.454104540861071 2609 6732859
SGTC_1944 st076371 56.9 µM -0.116695801336533 0.45173921709393 no 1871 0.453550558795833 2613 24208455
SGTC_681 1642-0006 26.6 µM -0.117408757678711 0.451458381513102 no 1872 0.453268072224258 2609 4446530
SGTC_438 sphingosine 6.67 µM -0.117747721841127 0.451324871053381 no 1873 0.453133776599208 2616 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1746 st038117 42 µM -0.117886243947456 0.451270311854365 no 1874 0.453078896490148 2711 2898218
SGTC_3011 9081274 71.4286 µM -0.118556903601453 0.451006174607575 no 1875 0.452813205201903 2647 6625322
SGTC_167 3672-0051 66.205 µM -0.119690780833919 0.450559649943023 no 1876 0.452364051842592 2611 3237971
SGTC_3281 9140613 49.47 µM -0.121326236884065 0.449915712207433 no 1877 0.451716319745273 2654 16013766
SGTC_1539 benzyladenosine 56 µM -0.121424093704386 0.449877186629485 no 1878 0.451677567027313 2617 92208 A nucleotide analog.
SGTC_3259 9138485 49.47 µM -0.123106458518683 0.449214924990798 no 1879 0.451011398513731 2732 17646153
SGTC_3190 9110366 49.47 µM -0.124146740412298 0.44880548946634 no 1880 0.450599545443 2657 17123768
SGTC_1991 st073000 8.92 µM -0.124446361528709 0.448687574283505 no 1881 0.450480933713896 2823 4301969 YIL048W NEO1
SGTC_46 0329-0187a 2.197 µM -0.124638322558199 0.448612030855179 no 1882 0.450404943965032 2696 46494817
SGTC_1044 1222-0021 1.78 µM -0.124800260127782 0.448548304164862 no 1883 0.450340840725401 2765 4306703
SGTC_897 1000-0139 31.4 µM -0.125155184546972 0.448408636722078 no 1884 0.450200347873798 2697 6151020
SGTC_952 1185-0122 232 µM -0.125412282356145 0.448307469333891 no 1885 0.450098582485413 2597 678600
SGTC_1101 ebselen 5.29 µM -0.125894211023928 0.448117840589259 no 1886 0.449907832575285 2643 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_605 1315-0399 119 µM -0.127631266293226 0.44743444473674 no 1887 0.449220393277374 2728 24020461
SGTC_2761 levamisole 97.89 µM -0.128547896775244 0.447073884850257 no 1888 0.448857698230852 2689 26879 An alkaline phosphatase inhibitor.
SGTC_55 0767-0285 6.563 µM -0.129135668222407 0.446842705841682 no 1889 0.448625149563 2668 3116166
SGTC_1910 st062352 60.4 µM -0.129146226753198 0.446838553183775 no 1890 0.448620972297217 2602 2245730
SGTC_2752 diclazuril 33.15 µM -0.129624425105347 0.446650484444073 no 1891 0.448431788921756 2734 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2946 9065502 71.43 µM -0.129917958193663 0.446535047916303 no 1892 0.44831566806096 2619 16489101
SGTC_676 falcarinol 140 µM -0.130171024763283 0.446435529123141 no 1893 0.448215559194899 2672 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3180 9109287 49.47 µM -0.130636291428418 0.446252571144148 no 1894 0.44803151616001 2748 18891271
SGTC_1622 st003707 19.4 µM -0.131368192987146 0.445964786827802 no 1895 0.447742024446418 2743 10140899
SGTC_2797 7859098 81.82 µM -0.13255442846928 0.445498418542883 no 1896 0.447272887544866 2675 972681
SGTC_577 r071-0003 38.6 µM -0.132648812589624 0.445461314671701 no 1897 0.447235563314857 2648 4568517 YMR134W ERG29
SGTC_2347 9049783 174.81 µM -0.133143630520335 0.445266801842773 no 1898 0.447039895063103 2747 6467988 YPL169C MEX67
SGTC_2597 laccaic acid a 100 µM -0.133563904394918 0.445101602613477 no 1899 0.446873714250682 2737 5491415 A textile dye.
SGTC_2806 7952793 58.44 µM -0.133876427112939 0.444978763868373 no 1900 0.446750145450724 2767 2972490
SGTC_2896 9052656 71.43 µM -0.134726208054756 0.444644779619352 no 1901 0.446414175536129 2650 6469436
SGTC_1283 0922-0125 16.4 µM -0.134948261835455 0.444557513635095 no 1902 0.446326390545827 2740 3360884
SGTC_350 k064-0020 19.8 µM -0.135852626130462 0.444202130961479 no 1903 0.445968893516099 2775 2790705
SGTC_626 0214-0009 33 µM -0.136855780384832 0.443807979870613 no 1904 0.445572396006379 2747 3437874
SGTC_2180 6301957 200 µM -0.137377397012195 0.443603052508743 no 1905 0.445366248108112 2671 845462
SGTC_1152 3909-8331 15.9 µM -0.137529952434463 0.443543120955428 no 1906 0.445305959530231 2646 16001939
SGTC_40 0327-0103 19.753 µM -0.137907021395396 0.44339499457254 no 1907 0.44515695058174 2705 409036
SGTC_620 0109-0052 432 µM -0.138701531561518 0.443082908038176 no 1908 0.444843003894364 2685 493037
SGTC_1388 3346-4487 254 µM -0.138827149093833 0.443033568233963 no 1909 0.444793369921905 2720 3345614
SGTC_3052 9092717 49.47 µM -0.138980648543225 0.442973278225153 no 1910 0.444732720427489 2809 25237534
SGTC_2653 dihydrofissinolide 100 µM -0.139845167521782 0.44263374563556 no 1911 0.444391162696855 2686 6857746
SGTC_1895 st058434 18.3 µM -0.140016931230419 0.442566291885991 no 1912 0.44432330648997 2725 5393175
SGTC_221 trifluoperazine 10.304 µM -0.140683966969544 0.442304354440739 no 1913 0.444059805809418 2657 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2567 aureobasidin a 60 nM -0.144559010835243 0.44078317065782 no 1914 0.442529530909782 2920 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1425 4048-4433 7.33 µM -0.145108710877098 0.440567451113639 no 1915 0.442312520400584 2697 23734946
SGTC_618 k072-0232 33.2 µM -0.146675048286803 0.439952868107405 no 1916 0.441694257075295 2750 5872756 YGL099W LSG1
SGTC_2850 9015429 58.44 µM -0.147475048163358 0.439639028283319 no 1917 0.441378536527734 2722 6457570
SGTC_2412 st077135 33.4 µM -0.148158413550393 0.439370974181175 no 1918 0.441108875357727 2962 13258915
SGTC_782 0083-0095 30.5 µM -0.148266357512985 0.439328635064487 no 1919 0.441066282344192 2651 3591729 An indicator and reagent.
SGTC_1003 4049-0218 100 µM -0.148339941392723 0.439299773482452 no 1920 0.44103724767716 2815 295161
SGTC_1616 st002734 56.1 µM -0.149334725762963 0.438909623954459 no 1921 0.44064475764117 2700 4026101
SGTC_1779 st039427 55 µM -0.150818803658055 0.438327686339544 no 1922 0.440059326381447 2671 1124498
SGTC_1502 4534-4282 27.7 µM -0.153252954777501 0.437373494611226 no 1923 0.43909939948711 2702 3278949
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.154213200395906 0.436997176405912 no 1924 0.438720817142641 2652 688667
SGTC_1797 st048695 56.8 µM -0.154837411191614 0.436752580077316 no 1925 0.438474748497858 2801 592262 YIL048W NEO1
SGTC_2307 7538926 6.34 µM -0.15516075648484 0.436625887072227 no 1926 0.438347292667495 2752 96582
SGTC_128 0906-2981 13.371 µM -0.156577956884218 0.436070677111027 no 1927 0.437788738047291 2800 6740226
SGTC_742 0kpi-0133 140 µM -0.157682304017855 0.435638119464948 no 1928 0.437353572690965 2836 2728852
SGTC_490 phenamil 164 µM -0.158258367374614 0.435412513859846 no 1929 0.437126606336371 2791 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2 0422-0095 29 µM -0.159372307399767 0.434976317516544 no 1930 0.436687777763437 2628 6790840
SGTC_3350 9150499 3.57 µM -0.160111021258002 0.434687095737704 no 1931 0.436396809736043 2684 4910996 YPR165W RHO1
SGTC_634 1611-4317 11.2 µM -0.160711611701819 0.434451977886731 no 1932 0.436160271752665 2679 2843522
SGTC_1808 st050063 61.5 µM -0.161411557559815 0.434177993850024 no 1933 0.435884632207544 2760 4011993
SGTC_1634 st006576 41 µM -0.161545177508822 0.43412569377581 no 1934 0.435832016041943 2800 3915356
SGTC_3270 9137563 49.47 µM -0.162293371704193 0.433832865031912 no 1935 0.435537417050042 2811 17015724
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.163578048123047 0.433330152303382 no 1936 0.435031663483217 2674 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1457 k015-0032 57.3 µM -0.164543406643537 0.432952464279281 no 1937 0.434651689409231 2675 4302660
SGTC_2690 usnic acid 100 µM -0.165257190290983 0.432673242069353 no 1938 0.434370776330375 2867 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1527 coumarin 137 µM -0.165471861826258 0.432589272127085 no 1939 0.434286297762404 2935 323 A hepatotoxic, DNA x-linker.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.166007916618917 0.432379604670474 no 1940 0.434075360030456 2668 6708630 An antioxidant.
SGTC_2028 5153890 36.43 µM -0.166642618943428 0.432131377764339 no 1941 0.43382562873746 2694 2830968 YPR165W RHO1
SGTC_1188 1403-0014 4.57 µM -0.167746530476756 0.431699710832371 no 1942 0.43339134439119 2727 9614867
SGTC_2902 5787006 60.46 µM -0.167954199858446 0.431618514142909 no 1943 0.433309655183486 2718 591003
SGTC_1574 spiramycin 23.7 µM -0.168701652872135 0.431326291289734 no 1944 0.433015659306281 2677 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2290 7904846 200 µM -0.17019180066194 0.430743818164829 no 1945 0.432429649887688 2792 2962154
SGTC_1012 4112-3522 18 µM -0.173636194981435 0.429398042225829 no 1946 0.431075692299852 2802 3112398
SGTC_1009 4106-0057 9.87 µM -0.174547897523303 0.429041963151568 no 1947 0.43071744583832 2706 2928005
SGTC_1992 st073643 23.3 µM -0.177285367472894 0.427973151372065 no 1948 0.429642121903194 2704 3161292
SGTC_2177 5811945 192 µM -0.177352956372878 0.427946768759988 no 1949 0.429615578421893 2868 5343475
SGTC_1995 st072814 61.1 µM -0.178015979518731 0.42768798178536 no 1950 0.429355213168909 2725 5769371
SGTC_487 nimodipine 119 µM -0.178062313159326 0.427669898295194 no 1951 0.42933701937078 2783 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2475 5812728 15.03 µM -0.179365064057794 0.42716151184693 no 1952 0.428825530672167 2703 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1511 0906-3109 28.5 µM -0.179442469239135 0.427131308991612 no 1953 0.428795143445899 2703 2882180
SGTC_775 4577-0580 57.3 µM -0.179646435064827 0.427051725275971 no 1954 0.428715073880952 2944 2006902
SGTC_1432 4049-0298 68.4 µM -0.181243629148509 0.426428632409388 no 1955 0.428088175265221 2828 741646
SGTC_99 0109-0120 622.8 µM -0.182354314144092 0.425995443226916 no 1956 0.427652338317122 2753 759414
SGTC_3313 9133968 57.047 µM -0.183131791237885 0.425692264830275 no 1957 0.42734730588278 2703 1494643
SGTC_1128 3448-9350 235 µM -0.183688743218191 0.425475107535972 no 1958 0.427128820128162 2839 619386
SGTC_2344 7990960 76.95 µM -0.185092683848162 0.424927807209096 no 1959 0.426578169952738 2769 140813
SGTC_1956 st077085 54 µM -0.185180312013774 0.42489365177287 no 1960 0.426543805379823 2774 24208685
SGTC_3095 9117207 49.47 µM -0.18537822084035 0.42481651355572 no 1961 0.426466194803189 2873 17015229
SGTC_2603 homopterocarpin 100 µM -0.185489795182365 0.424773026891386 no 1962 0.42642244182454 2850 101795 A weak amylase inhibitor.
SGTC_1047 2043-3044 82 µM -0.185683244410519 0.424697631245971 no 1963 0.426346584415713 2739 669592
SGTC_111 0083-0039 52.457 µM -0.188130210476335 0.423744180004586 no 1964 0.425387289684656 2712 759313
SGTC_431 k089-0097 107 µM -0.188571797831203 0.423572164502455 no 1965 0.425214219142707 2818 5499420
SGTC_3126 9127922 49.47 µM -0.188693516982078 0.423524752703752 no 1966 0.425166516505895 2996 45595682
SGTC_1762 st045503 25.4615 µM -0.190188781916453 0.422942410666008 no 1967 0.424580600710036 2807 4645554
SGTC_1769 st044406 64.4 µM -0.191031347020832 0.422614341496289 no 1968 0.424250517004835 2746 670903
SGTC_2533 agelasine 13.65 µM -0.191788265465609 0.42231966628224 no 1969 0.423954031568184 2896 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_353 1988-1175 58.3 µM -0.192689876307821 0.421968717752681 no 1970 0.423600926204826 2674 2788357
SGTC_1248 0469-0687 58.6 µM -0.193992035972474 0.421461966569597 no 1971 0.423091058912018 2856 4017482
SGTC_1814 st052110 31.539 µM -0.194414925786076 0.421297421819208 no 1972 0.422925501899699 2855 674163
SGTC_540 1187-0821 17.3 µM -0.196277594566152 0.420572828745813 no 1973 0.422196448621426 2755 847520
SGTC_1643 st009866 20.2 µM -0.198501788891784 0.419707951962196 no 1974 0.421326242633212 2842 3156273 YOR207C RET1
SGTC_3014 9081533 49.47 µM -0.200425416079178 0.418960263020578 no 1975 0.420573941793097 2896 21367265
SGTC_683 panaxydol 45 µM -0.200446412607574 0.418952103551746 no 1976 0.420565731970636 2806 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1783 st039459 87.517 µM -0.20056260533663 0.418906950481778 no 1977 0.420520300243027 2980 729761
SGTC_2211 7117706 200 µM -0.200842139138079 0.418798326639368 no 1978 0.420411005973686 2837 822771
SGTC_2702 st077768 96.8 µM -0.202282333061421 0.418238780985379 no 1979 0.419848005331458 2846 6484119
SGTC_2627 acetyl isogambogic acid 100 µM -0.202467387304737 0.418166895486877 no 1980 0.419775675788455 2862 6857789 A caspase activator and apoptosis inducer.
SGTC_885 0865-0106 16.8 µM -0.202570966010881 0.418126660872344 no 1981 0.419735192622695 2766 2793380
SGTC_1857 st056007 79.3 µM -0.202806731755542 0.418035082079321 no 1982 0.419643048050131 2844 619834
SGTC_2972 9093619 59.92 µM -0.204377976405878 0.417424875215966 no 1983 0.419029069618402 2781 25236256
SGTC_2497 7-hydroxyflavone 100 µM -0.206344237293891 0.41666154049612 no 1984 0.418261012800386 2954 5281894
SGTC_1907 st060210 83.7 µM -0.207263334060636 0.416304839620216 no 1985 0.417902103775885 2947 688793
SGTC_1330 1469-0054 61.8 µM -0.207594800921703 0.416176214434619 no 1986 0.417772682098361 2929 7102664
SGTC_1360 1598-0022 39.8 µM -0.208137501689695 0.415965639656305 no 1987 0.417560803092892 2873 761525
SGTC_2948 9070189 9.45 µM -0.208938093251865 0.415655044038647 no 1988 0.417248283132033 2927 6473636 YDL196W YDL196W
SGTC_1993 st073995 70.8 µM -0.209142415379788 0.415575784138168 no 1989 0.417168532046119 2793 3098394
SGTC_2197 6588183 93.1375 µM -0.20945101039601 0.415456081588447 no 1990 0.417048087590655 2784 884136
SGTC_1211 1056-0033 32.3 µM -0.210319302979515 0.415119317124454 no 1991 0.416709235302964 2811 6741922
SGTC_35 0133-0054 64.071 µM -0.210825894854399 0.414922865894408 no 1992 0.416511565743334 2814 99677
SGTC_160 3453-0671 289.699 µM -0.21285713623901 0.414135385055526 no 1993 0.415719198248053 2820 5322268
SGTC_1850 st056238 17 µM -0.213626137423088 0.41383734508235 no 1994 0.41541930758411 2741 5393177
SGTC_2040 5100729 123 µM -0.213969156666548 0.413704417918321 no 1995 0.415285554787586 2778 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_668 1682-0499 62.6 µM -0.214560535474176 0.413475269432388 no 1996 0.415054982710296 2837 682214
SGTC_57 miconazole 162.5 nM -0.215934420199839 0.412943028070316 no 1997 0.414519433262133 2742 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1729 st035615 45.989 µM -0.215995538160764 0.412919354752299 no 1998 0.414495612755975 2911 17385451
SGTC_1118 chelidonine 707.474 nM -0.216809070512677 0.41260427282952 no 1999 0.414178571421986 2888 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1920 st075728 45.7 µM -0.218266390110385 0.412039992340019 no 2000 0.413610779971964 2988 3400306
SGTC_1504 k297-0033 30 µM -0.219280738482504 0.411647339481379 no 2001 0.413215682627132 2752 4388117
SGTC_1664 st014217 9.02 µM -0.219639790322629 0.411508372186707 no 2002 0.413075849909044 2819 3982782
SGTC_1448 4255-0083 152 µM -0.220149260429709 0.411311206114511 no 2003 0.412877455733911 2942 5399660
SGTC_3075 9116269 49.47 µM -0.220293750675634 0.411255292140562 no 2004 0.412821193432257 2996 17015205 YNL244C SUI1
SGTC_1652 st011932 78 µM -0.220879862954238 0.411028500403461 no 2005 0.412592988612847 2879 1551076
SGTC_1313 1220-0047 237 µM -0.221031197298709 0.410969947544246 no 2006 0.412534070864018 2840 3528706
SGTC_3214 9129694 49.47 µM -0.224975202977722 0.409444673196625 no 2007 0.410999282475473 2934 17158655
SGTC_772 k072-0172 35.3 µM -0.225417715281756 0.40927362443846 no 2008 0.410827165728809 2828 5861980
SGTC_704 1310-0270 142 µM -0.226974566243987 0.408671976568654 no 2009 0.410221759630295 2881 5718033
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.227877750631432 0.408323037855066 no 2010 0.409870640056106 2809 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_450 aminopyrene 156 nM -0.228951738962365 0.407908204896382 no 2011 0.409453213262868 2898 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_551 k048-0028 34.9 µM -0.230351139017422 0.407367835082332 no 2012 0.40890946282404 2975 6836383
SGTC_3352 9151559 45.5865 µM -0.232422717262896 0.406568231564173 no 2013 0.408104853075476 2902 17159339
SGTC_639 0833-0042 114 µM -0.233140156732243 0.406291399439144 no 2014 0.407826286681731 2825 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2201 6605497 169.863 µM -0.233415990082799 0.406184978482196 no 2015 0.407719198886409 2857 670741
SGTC_2728 chlorpromazine 9.18 µM -0.235553582335151 0.40536049644922 no 2016 0.406889547921393 2784 2726 A thorazine and dopamine antagonist.
SGTC_2383 9036125 200 µM -0.236562054561235 0.404971668230608 no 2017 0.406498280371367 2816 79580
SGTC_1672 st016598 6.51 µM -0.240538936899485 0.403439252653276 no 2018 0.404956240925117 2883 4665860 YNL267W PIK1
SGTC_2168 5727979 200 µM -0.241355384419449 0.403124832724233 no 2019 0.404639844382216 2780 695210
SGTC_3003 9075612 71.4286 µM -0.244844946375332 0.401781685017786 no 2020 0.403288245351853 2901 6501993
SGTC_1530 rhein 70.4 µM -0.245875149613309 0.401385376209416 no 2021 0.402889440569911 2829 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_869 0564-0080 44.1 µM -0.247732233790769 0.400671231088593 no 2022 0.402170795069458 2878 6843321
SGTC_2065 5221596 34.26 µM -0.248276037028748 0.400462173269927 no 2023 0.401960419172487 2968 788581
SGTC_1483 3453-0561 55.9 µM -0.248461693258064 0.400390806762995 no 2024 0.401888602643879 2940 4546991
SGTC_2987 9018338 71.43 µM -0.248718551610402 0.400292075546885 no 2025 0.401789248794443 2803 5055682
SGTC_2238 6671620 73.2395 µM -0.248739920911846 0.400283861901583 no 2026 0.401780983348128 2776 729941
SGTC_580 1123-0028 41 µM -0.249667790456935 0.399927262438363 no 2027 0.401422134487502 2832 1677248 YPR107C YTH1
SGTC_203 k066-0004 30.888 µM -0.250167403079956 0.399735285510411 no 2028 0.401228946238174 2851 6795412
SGTC_2445 5742597 35.57 µM -0.253957844756257 0.398279594955538 no 2029 0.399764062803416 2854 1774255
SGTC_1810 st050138 53 µM -0.254935471547387 0.397904373401077 no 2030 0.399386469434995 2939 3444541
SGTC_2608 thymoquinone 42.66 µM -0.255508037984484 0.397684661304818 no 2031 0.399165368092884 2868 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_195 4234-0266 16.654 µM -0.255602996157919 0.397648225945021 no 2032 0.399128702321123 2885 2303354
SGTC_2156 5649887 115 µM -0.256751027694038 0.397207798086262 no 2033 0.398685488583341 2967 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2275 7947463 200 µM -0.257036285063725 0.397098382988605 no 2034 0.398575381198813 2935 1225414
SGTC_2748 diazoxide 86.69 µM -0.257209461727896 0.39703196221622 no 2035 0.398508540134076 2945 3019 A potassium channel activatior.
SGTC_774 k060-0086 136 µM -0.258417089916524 0.396568867485699 no 2036 0.398042514282663 2911 5911235
SGTC_1840 st055363 71 µM -0.259629488685587 0.396104090080223 no 2037 0.397574793730248 2885 676033
SGTC_2739 tacrine 100.86 µM -0.259815732955037 0.396032705739402 no 2038 0.397502957235028 2969 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2881 9058953 51.95 µM -0.261293334735707 0.395466489207868 no 2039 0.396933153097481 2822 17122249
SGTC_689 0833-0039 98 µM -0.262378251889569 0.395050889670617 no 2040 0.396514918991896 2913 5374726
SGTC_1491 4138-0063 26.5 µM -0.262418194057897 0.395035591287682 no 2041 0.396499523608744 2896 23883227
SGTC_2057 5236571 38.335 µM -0.264180255907434 0.394360859453028 no 2042 0.395820512143276 3036 54684039 YBR257W POP4
SGTC_289 k017-0060 526 µM -0.266340147849103 0.39353422222095 no 2043 0.394988627924375 2877 5512909
SGTC_2016 5121758 140 µM -0.266780755089416 0.393365651107042 no 2044 0.394818986305219 2814 2795203
SGTC_976 1348-1067 47.6 µM -0.267351169154703 0.393147447130775 no 2045 0.394599396371904 2900 5310671 YGL099W LSG1
SGTC_1556 plumbagin 1.48 µM -0.268392538738383 0.392749172282617 no 2046 0.394198591064006 2860 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_27 0485-0001 32.618 µM -0.268604698029286 0.392668045093131 no 2047 0.394116948309606 2855 2054479
SGTC_745 0469-0705 296 µM -0.270430014967196 0.391970258595795 no 2048 0.393414725707432 3089 3486736
SGTC_1761 st044296 37 µM -0.272489300251091 0.391183447147607 no 2049 0.392622908645849 2876 1826700
SGTC_967 1306-0166 352 µM -0.272679851575098 0.391110663773949 no 2050 0.392549662043278 3046 4437607
SGTC_2301 7769476 200 µM -0.274647630626247 0.390359270318872 no 2051 0.391793484498276 2953 977820
SGTC_188 3229-0966 278.469 µM -0.277285415069485 0.389352678883895 no 2052 0.390780478874496 2978 5722370
SGTC_828 2074-0507 139 µM -0.277338413273943 0.38933246209146 no 2053 0.390760133195548 3041 X828
SGTC_1066 ketoconazole 628 nM -0.278829435029635 0.388763817141466 no 2054 0.390187862025306 3052 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_658 3253-0951 102 µM -0.279966366769413 0.388330374849932 no 2055 0.38975165442383 2935 1184878
SGTC_1019 4262-0212 3.4 µM -0.281281076509207 0.387829330089462 no 2056 0.389247411696528 2981 4677213
SGTC_523 1934-0222 13.7 µM -0.282748460897008 0.387270320500154 no 2057 0.388684832461635 2913 1361595
SGTC_1112 tnp00069 1.16933 µM -0.282822695105061 0.38724204669803 no 2058 0.388656378064821 3001 145826
SGTC_76 0433-0009 400.328 µM -0.282905977532239 0.387210327385936 no 2059 0.388624456144895 3022 2841569
SGTC_464 bw-b 70c 158 µM -0.283344854016082 0.387043187400308 no 2060 0.388456248453464 3035 5353454
SGTC_2000 st075254 36.4 µM -0.283466434950376 0.386996888700905 no 2061 0.388409653965344 2909 17234175
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.285255317839752 0.386315858288541 no 2062 0.387724271236759 2931 689007
SGTC_1741 st038134 10.228 µM -0.286128146121501 0.385983698187746 no 2063 0.387389987416881 3149 1272587
SGTC_2077 5212015 200 µM -0.287400590910576 0.385499611371335 no 2064 0.386902804397122 2845 780900
SGTC_811 0416-0114 265 µM -0.287976408815577 0.385280606707404 no 2065 0.386682398553374 3001 6612453
SGTC_3106 9121286 49.47 µM -0.289019120312508 0.384884118430134 no 2066 0.386283372882426 3117 15943471
SGTC_3257 9139206 32.98 µM -0.289555445571935 0.384680229017671 no 2067 0.386078178303576 3032 4910041
SGTC_2895 9054447 58.44 µM -0.290740467022453 0.384229844410476 no 2068 0.385624909810412 2927 2697450
SGTC_356 1634-0012 32.5 µM -0.291015673267788 0.384125270619031 no 2069 0.385519666255187 3040 735457
SGTC_2395 5646831 180.19 µM -0.292598025790248 0.383524166898681 no 2070 0.384914711476326 3090 6808628
SGTC_2754 granisetron 64.02 µM -0.292649756636235 0.383504520119253 no 2071 0.384894938793426 3062 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2916 7875993 68.79 µM -0.293846160076349 0.383050223542325 no 2072 0.384437730335165 2965 1299250
SGTC_152 4469-0003 551.229 µM -0.294091768620394 0.382956981297122 no 2073 0.384343890300605 2900 697280
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.294606660350099 0.382761531039123 no 2074 0.384147186829556 3042 5024745
SGTC_2462 5162487 171.77 µM -0.295494673370076 0.382424516019233 no 2075 0.383808010406565 2888 2259986
SGTC_853 0419-0306 21 µM -0.295764986644791 0.38232194551053 no 2076 0.383704781952891 2904 762713
SGTC_1489 4065-0444 182 µM -0.296047083274241 0.382214912606281 no 2077 0.383597062418786 3059 2877968
SGTC_1515 3460-0031 42.1 µM -0.29620460451838 0.382155149922183 no 2078 0.383536916322496 2947 2876596
SGTC_1233 0325-0408 14.2 µM -0.296399715549893 0.382081129774299 no 2079 0.383462421265866 3033 12874
SGTC_2624 nerol 100 µM -0.296989125474256 0.381857548870886 no 2080 0.383237405702067 2900 637566 A natural product oil.
SGTC_3062 9077494 49.47 µM -0.297831960378228 0.381537904725302 no 2081 0.382915710017508 3061 16459633
SGTC_207 4185-0010 4.486 µM -0.297915480862718 0.381506234075032 no 2082 0.382883836069004 3015 3761753
SGTC_101 0490-5701 117.494 µM -0.298446925074304 0.381304731042898 no 2083 0.382681039435935 2914 4661669
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.298806959179109 0.381168238352392 no 2084 0.382543670372275 2985 17037758
SGTC_1200 1643-0193 18.4 µM -0.29890565899268 0.381130822802813 no 2085 0.382506014572861 3031 5403974
SGTC_2311 7694451 200 µM -0.299466395229666 0.380918277598959 no 2086 0.382292104449049 2985 2163142
SGTC_911 3456-4043 236 µM -0.299682359575229 0.380836426612343 no 2087 0.382209727768942 3026 914281
SGTC_942 3253-1115 227 µM -0.30006812138506 0.380690235265762 no 2088 0.382062597410307 3135 46497897
SGTC_1618 st003135 44.5 µM -0.300818199049716 0.380406028678663 no 2089 0.381776564992535 2948 1270615
SGTC_1120 ficusin 1.78878 µM -0.300898946701306 0.380375437006492 no 2090 0.381745776764652 3084 6199 A DNA cross-linker.
SGTC_180 1486-1293 102.781 µM -0.304191791405032 0.37912856484881 no 2091 0.380490889111763 3071 4140536
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.304309783289491 0.379083909156129 no 2092 0.380445946200678 2900 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3255 9139072 49.47 µM -0.305195025305964 0.378748928336832 no 2093 0.380108810508819 3015 17646060
SGTC_612 0302-0167 22.4 µM -0.307942158638246 0.377709977649808 no 2094 0.37906317277125 3016 235821
SGTC_2618 avocadyne 43.43 µM -0.308717086611313 0.37741706370657 no 2095 0.378768372537533 2908 3015189
SGTC_2856 9022925 19.48 µM -0.309114816934574 0.377266753543412 no 2096 0.378617094247028 3112 4944862
SGTC_1097 itavastatin 7.23 µM -0.309578671538201 0.377091477192416 no 2097 0.378440688820898 2988 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2374 9071832 200 µM -0.310539596494599 0.376728453883496 no 2098 0.378075326538598 2914 17381698
SGTC_2582 agaric acid 100 µM -0.311751041470476 0.376270943117881 no 2099 0.377614867073637 3069 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1875 nocodazole 6 µM -0.312380909880109 0.376033137488511 no 2100 0.377375528353118 3048 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_574 1315-0397 40 µM -0.314152385753655 0.375364572707681 no 2101 0.376702651953091 2946 6794277
SGTC_957 1187-1561 14.1 µM -0.314396662095246 0.375272410777922 no 2102 0.376609895492196 2972 1538454
SGTC_2938 9059746 27.26 µM -0.314758130340102 0.375136047101416 no 2103 0.376472652065296 3079 6471769
SGTC_1820 st053765 18.6 µM -0.315218635288728 0.374962344493524 no 2104 0.376297828683043 3021 3690829
SGTC_2340 7987427 183.45 µM -0.315377388599367 0.37490246857241 no 2105 0.376237566392761 3087 2239331
SGTC_2128 5255449 168.493 µM -0.316777432701785 0.374374554027562 no 2106 0.37570624454956 2971 736008
SGTC_230 MPP+ 141.667 µM -0.318396822339547 0.373764224568143 no 2107 0.375091974183283 3004 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1359 1582-0056 520 nM -0.322330875203709 0.372282845695735 no 2108 0.373601022621848 3078 3661189
SGTC_2716 st080858 38.6235 µM -0.324208400331788 0.371576522350264 no 2109 0.372890131365633 3129 5296050
SGTC_2491 paeonol 100 µM -0.326746378396247 0.370622424440076 no 2110 0.371929859472154 2922 11092 Increases levels of cortical cytochrome oxidase.
SGTC_318 1488-0629 67.2 µM -0.327464066295519 0.370352769169486 no 2111 0.371658458500308 3059 3662576
SGTC_1939 st074455 53.6 µM -0.328061001377406 0.370128532601315 no 2112 0.371432770011313 3199 1644229
SGTC_326 k292-0812 17.5 µM -0.328838763140364 0.369836435350091 no 2113 0.371138781102431 3071 3579357
SGTC_268 camptothecin 39.6153 µM -0.330721470208008 0.36912967450466 no 2114 0.370427441595399 3071 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3103 9120822 49.47 µM -0.330762425809782 0.369114304838211 no 2115 0.370411972333602 3203 17141819
SGTC_1375 2910-0797 186 µM -0.331486953562839 0.36884244136351 no 2116 0.370138347011014 3043 742508
SGTC_379 3970-0972 5.9 µM -0.33268302055541 0.36839378653995 no 2117 0.369686783901177 3038 2898042 YBL034C STU1
SGTC_2565 isoliquiritigenin 100 µM -0.333158556209853 0.368215458905506 no 2118 0.369507300057775 3128 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3200 9114385 49.47 µM -0.333228406484686 0.368189267183744 no 2119 0.369480938506989 3127 17018030 YLR208W SEC13
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.334386661921795 0.367755046125603 no 2120 0.369043901489068 2916 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_561 1550-0330 72.9 µM -0.334656126276451 0.36765405021876 no 2121 0.368942250497024 2994 6812934
SGTC_2685 mycophenolic acid 18.85 µM -0.336424413555078 0.366991519136501 no 2122 0.368275420969237 3025 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2303 7774051 200 µM -0.336557408268041 0.366941705474521 no 2123 0.368225284043621 3186 2953184
SGTC_440 fluspirilene 35.1 µM -0.337836363520053 0.366462782524046 no 2124 0.367743252598517 3218 3396 An atypical antipsychotic.
SGTC_264 promethazine 12.5 mM -0.338523013595381 0.366205742367874 no 2125 0.367484543693907 3072 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_855 0428-0020 25 µM -0.338641146196496 0.366161526732819 no 2126 0.36744004097503 3024 6812414
SGTC_2225 6654152 15.4 µM -0.339488250040002 0.365844517877896 no 2127 0.367120973597836 3056 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2246 7293507 91.5585 µM -0.340277583299511 0.365549210732858 no 2128 0.36682374846962 3155 887656
SGTC_2435 5706476 10.6 µM -0.341216702376948 0.365197969175642 no 2129 0.366470225164187 3150 5725375
SGTC_994 3910-0338 138 µM -0.341897069165234 0.36494357461323 no 2130 0.366214177671921 3187 3479481
SGTC_2049 5262831 67.185 µM -0.342453334190771 0.364735626847437 no 2131 0.366004878564175 3077 763417
SGTC_2470 5664817 21.68 µM -0.34352518214737 0.364335051688778 no 2132 0.365601699775069 2986 2859561
SGTC_820 1582-0060 59.9 µM -0.343873133597233 0.364205045757005 no 2133 0.365470848697389 3032 3848840
SGTC_1889 st059080 5.18 µM -0.34398648903631 0.364162695866719 no 2134 0.365428223482824 3184 176925 Isolated from Daphnopsis sellowiana.
SGTC_2770 toltrazuril 17.5 µM -0.345096886360481 0.363747936279738 no 2135 0.36501076708011 3067 68591 Kills coccidiodes.
SGTC_271 rotenone 740 µM -0.345837850179011 0.363471257576046 no 2136 0.364732288988225 3127 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2978 9011784 42.97 µM -0.347360129344294 0.362903056297696 no 2137 0.364160391422972 3121 2994934
SGTC_3219 9131112 49.47 µM -0.348688938443086 0.362407315616384 no 2138 0.363661424768063 3124 17612988 YMR079W SEC14
SGTC_876 0720-0963 56.8 µM -0.349764872555623 0.362006084288569 no 2139 0.363257581757863 3201 765861
SGTC_2133 5320837 200 µM -0.350409447094754 0.361765785746667 no 2140 0.363015718767148 3166 2841355
SGTC_2863 9028737 58.44 µM -0.351129890355091 0.361497267707187 no 2141 0.362745452288693 3093 6460917
SGTC_890 0929-0006 47.2 µM -0.35123528810038 0.361457990390317 no 2142 0.362705919196238 3027 1378169
SGTC_2356 9061756 188.97 µM -0.352127945833002 0.361125392895729 no 2143 0.362371155570785 3081 20104043
SGTC_153 4077-0274 519.67 µM -0.354316552884183 0.360310379116514 no 2144 0.361550831980964 3319 3121976
SGTC_3029 9088683 49.47 µM -0.354806272145128 0.360128099642417 no 2145 0.361367364607481 3161 25236615
SGTC_2026 5148700 152 µM -0.356216996773359 0.359603188603731 no 2146 0.360839032062588 3008 79838
SGTC_3108 9121785 49.47 µM -0.356633678596311 0.359448197692277 no 2147 0.360683030680639 2983 17140271
SGTC_1570 verbenone 133 µM -0.357809923819874 0.359010800868746 no 2148 0.36024278174091 3215 29025 A natural terpanoid with antifungal properties.
SGTC_2125 5246583 200 µM -0.358684166931166 0.358685825771969 no 2149 0.359915687128831 3199 835267
SGTC_336 4111-0029 111 µM -0.358813235652509 0.358637856792562 no 2150 0.359867405258392 3051 3131175
SGTC_2385 9074692 200 µM -0.36053773952963 0.35799715126846 no 2151 0.359222519739239 3067 17046906
SGTC_965 1291-5240 308 µM -0.360697490532424 0.357937819127481 no 2152 0.359162800436073 3168 2834598
SGTC_687 k029-0044 34.9 µM -0.362110651805291 0.357413115146265 no 2153 0.358634672026348 3162 5829338
SGTC_606 k015-0008 38.6 µM -0.363679778489823 0.356830817220807 no 2154 0.358048572625733 3190 1970475
SGTC_1522 st012842 45.6 µM -0.364385482304672 0.356569041395791 no 2155 0.357785087427015 2953 3491067 YOR116C RPO31
SGTC_2219 9098279 200 µM -0.364818342011539 0.356408508573389 no 2156 0.357623506218443 3148 902349
SGTC_1756 st041558 35.5 µM -0.365000733319028 0.356340873508128 no 2157 0.357555429423834 3231 3955792
SGTC_14 0354-0009 295 µM -0.366722917836376 0.355702469271048 no 2158 0.356912854929698 3044 1713507
SGTC_3262 9137218 49.47 µM -0.36722964999179 0.355514703418099 no 2159 0.356723862259557 2962 17650664
SGTC_1201 1889-3372 45.9 µM -0.368137382641879 0.355178437477299 no 2160 0.356385398931444 3053 5392199
SGTC_2092 5303694 80.6725 µM -0.368784265043398 0.354938871255257 no 2161 0.356144266984654 3061 1963699
SGTC_2241 6772625 37.8075 µM -0.369129397149756 0.354811078593126 no 2162 0.356015639031717 3087 2285411
SGTC_59 0330-0160 1.33 µM -0.369587308903618 0.354641552032007 no 2163 0.355845004308335 3096 4293482
SGTC_2935 9038016 29.96 µM -0.37077303833275 0.354202709088741 no 2164 0.35540329227919 3229 6463195
SGTC_590 k048-0076 22.4 µM -0.373381622314016 0.353237944271262 no 2165 0.354432217702037 3175 6832814
SGTC_1572 epiandrosterone 68.9 µM -0.373674930558309 0.353129525290186 no 2166 0.354323089444909 3008 441302 A steroid.
SGTC_1708 st033234 31.827 µM -0.373846744436926 0.353066021238731 no 2167 0.354259169932469 3182 674664
SGTC_2418 pentamidine 31.67 µM -0.374197823731509 0.352936271701854 no 2168 0.354128571497115 3164 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2975 9084847 53.72 µM -0.374420117748385 0.352854126606546 no 2169 0.354045888931234 3141 27211724
SGTC_2490 carminic acid 95.39 µM -0.375286288535703 0.3525341129097 no 2170 0.35372378119277 3060 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_168 3970-0862 530.542 µM -0.376717193715676 0.352005682246427 no 2171 0.353191891961977 3148 3135186
SGTC_1022 4477-0945 21.3 µM -0.378317382155568 0.351415073983574 no 2172 0.352597417118272 3053 4648966
SGTC_3171 9103192 49.47 µM -0.378589311589618 0.351314744052891 no 2173 0.352496430239498 3183 13018434
SGTC_90 0870-0863 4.608 µM -0.379050355457396 0.351144662938901 no 2174 0.352325235382491 3025 1738164
SGTC_2037 5169046 200 µM -0.383818030679942 0.349387600211531 no 2175 0.350556661603798 3190 5718022
SGTC_223 busulfan 5 mM -0.386021485472423 0.348576632992357 no 2176 0.34974037832327 3171 2478 A DNA alkylator.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.386578194986661 0.348371848956864 no 2177 0.349534251575918 3124 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3269 9137823 49.47 µM -0.386612614591766 0.348359189251503 no 2178 0.34952150886034 3052 17682936
SGTC_1555 citronellol 128 µM -0.387094321317783 0.348182032805589 no 2179 0.349343190742804 3164 8842 A terpine precursor.
SGTC_1303 1160-0052 261 µM -0.387298083561302 0.348107105485744 no 2180 0.349267772072815 3137 3562476
SGTC_840 0245-0196 390 µM -0.387589001421333 0.348000139635399 no 2181 0.349160104745146 3225 3827528
SGTC_2481 5478948 45.16 µM -0.388437466048072 0.34768824184172 no 2182 0.34884616134945 3229 77792
SGTC_790 1575-0012 79.1 µM -0.389601824485909 0.347260388455596 no 2183 0.348415501401926 3229 378741 YLR208W SEC13
SGTC_1924 st058459 75.1 µM -0.390166325340172 0.347053027827952 no 2184 0.348206780375924 3169 688683
SGTC_2726 cimetidine 79.27 µM -0.390877339160644 0.346791913098256 no 2185 0.347943952417959 3087 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2717 st081029 62.2815 µM -0.392752003425676 0.346103805145031 no 2186 0.347251328726287 3200 5292846
SGTC_1818 st052136 56.3 µM -0.393559596151852 0.345807529243955 no 2187 0.346953108096181 3191 674169
SGTC_805 3852-0218 479 µM -0.39404117361594 0.345630901199766 no 2188 0.346775320566094 3060 6615355
SGTC_330 1488-0319 80.1 µM -0.394501862134945 0.345461966032469 no 2189 0.34660527633344 3171 6846614
SGTC_1480 1070-0044 41.2 µM -0.394637099240807 0.345412380226095 no 2190 0.346555364979726 3171 3124987
SGTC_1220 1838-0075 193 µM -0.395511565685773 0.345091813924169 no 2191 0.346232693892368 3113 5529645
SGTC_361 000s-0510 1.45 µM -0.395994667529008 0.344914763665347 no 2192 0.346054481031942 3169 660
SGTC_2870 9038528 12.99 µM -0.396273311060008 0.344812660035018 no 2193 0.345951706899278 3208 6463316
SGTC_1178 0988-0033 191 µM -0.396698668593279 0.344656817640391 no 2194 0.345794841052587 3210 5392207
SGTC_2202 7226349 200 µM -0.397264388876861 0.34444959001853 no 2195 0.345586252420279 3087 844334
SGTC_2027 5150920 200 µM -0.397833142469177 0.344241298328932 no 2196 0.3453765926173 3142 786715
SGTC_1886 st057356 49.9 µM -0.398600742286306 0.343960259121796 no 2197 0.345093707291755 3092 24207747
SGTC_333 3486-0131 40.1 µM -0.398682051245782 0.343930494741815 no 2198 0.345063747380453 3247 6744690
SGTC_528 3492-0019 172 µM -0.398712066995714 0.34391950726491 no 2199 0.345052687722867 3180 2869262
SGTC_664 1222-0054 14.9 µM -0.400229143220471 0.343364342676326 no 2200 0.344493875651668 3120 6813991
SGTC_1665 st014639 11.4 µM -0.400559000271556 0.343243678211982 no 2201 0.344372418305751 3161 981133 YIL048W NEO1
SGTC_1340 1486-1359 257 µM -0.4006519062164 0.343209695324986 no 2202 0.344338212111794 3125 4309068
SGTC_2400 5203494 178.7 µM -0.403403972017554 0.342203628161108 no 2203 0.34332553259948 3143 6777674
SGTC_1972 st070201 17.4 µM -0.404099850668485 0.341949414166059 no 2204 0.343069647390889 3237 2829099
SGTC_83 0170-0301 39.027 µM -0.406099064540063 0.341219472851553 no 2205 0.34233490653474 3173 3089716
SGTC_698 k064-0052 127 µM -0.40648236647811 0.341079591628607 no 2206 0.342194105412025 3220 5088751
SGTC_3139 9095020 49.47 µM -0.407354002325435 0.340761580409528 no 2207 0.341874002684949 3067 25236292
SGTC_3346 9158254 43.5805 µM -0.407477328638046 0.340716594659954 no 2208 0.341828721052091 3192 17639500
SGTC_218 alverine citrate 93.75 µM -0.407836838324198 0.340585469210223 no 2209 0.341696733128079 3244 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2908 7930301 100 µM -0.409663595166496 0.339919486588777 no 2210 0.341026369403616 3120 2223178
SGTC_145 3737-0113 38.366 µM -0.410627172937102 0.339568395046796 no 2211 0.340672967828132 3262 6849351
SGTC_276 colchicine 750 µM -0.410901138678369 0.3394685976199 no 2212 0.34057251372529 3262 2833 A microtubule depolymerizer.
SGTC_411 enrofloxacin 100 µM -0.411824019799002 0.339132502821541 no 2213 0.340234207228101 3302 71188 A bacterial gyrase inhibitor.
SGTC_3045 9092950 49.47 µM -0.412002337729566 0.339067577750828 no 2214 0.34016885488356 3275 44120432
SGTC_2414 st077232 92.9 µM -0.413479517244769 0.338529924661285 no 2215 0.339627663123795 3070 729801
SGTC_1157 4092-0394 27.6 µM -0.41422201718791 0.338259799071192 no 2216 0.33935575940922 3317 3659885
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.41625408367367 0.337520947951284 no 2217 0.338612043936404 3099 15053
SGTC_2610 ononetin 44.17 µM -0.417819626947866 0.336952149458026 no 2218 0.338039499874846 3204 259632
SGTC_1839 st053978 48 µM -0.41825291087689 0.336794793053883 no 2219 0.337881107151855 3225 3788398
SGTC_582 0987-0078 156 µM -0.419256802989263 0.336430317781889 no 2220 0.337514231321555 3283 1625765
SGTC_1975 st070967 30.8 µM -0.419652864978296 0.336286564895073 no 2221 0.337369531555121 3301 261391
SGTC_2934 9036370 36.88 µM -0.419847070423678 0.336216085699277 no 2222 0.337298588107779 3207 6462800
SGTC_851 0394-0702 453 µM -0.421126649971886 0.335751856853212 no 2223 0.336831301105024 3272 762646
SGTC_583 1488-1091 88.9 µM -0.421741823697679 0.33552876221291 no 2224 0.336606736653602 3245 4303273
SGTC_404 fumagillin 50 µM -0.423294962824564 0.334965769628449 no 2225 0.336040034483276 3220 12015870 A methionine aminopeptidase binder.
SGTC_1026 k007-1105 30.6 µM -0.423943752230798 0.33473070164808 no 2226 0.335803417448587 3178 7066794
SGTC_972 1319-0219 195 µM -0.424272734999854 0.334611530055583 no 2227 0.335683460497479 3212 23903702
SGTC_1058 3448-5425 97.3 µM -0.425133038855222 0.334299970070925 no 2228 0.335369847160101 3195 7279705
SGTC_1169 aniline yellow 25.8 µM -0.425201929769756 0.334275026082846 no 2229 0.335344738769515 3161 6051 A DNA damaging agent.
SGTC_1073 triclabendazole 3.09 µM -0.425971513662595 0.333996425301209 no 2230 0.335064301689086 3245 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_796 1234-0020 70.7 µM -0.430951054132216 0.332195974051124 no 2231 0.333251980046153 3179 46495034
SGTC_2207 7258803 200 µM -0.432848853336394 0.331510802499687 no 2232 0.33256228968846 3242 3666799
SGTC_954 1189-0853 2.85 µM -0.433276252887083 0.331356574043564 no 2233 0.332407043966476 3228 2828194
SGTC_1882 5615643 20 µM -0.433837723849282 0.331154008963974 no 2234 0.332203142741928 3241 2253075
SGTC_269 exalamide 29 µM -0.434234814481684 0.331010778134051 no 2235 0.332058967103473 3173 3316 A derivative of salicylamide.
SGTC_3165 9101544 49.47 µM -0.434435449353053 0.330938418417515 no 2236 0.331986130060504 3241 5002184
SGTC_1734 st037168 69.4 µM -0.435575641630219 0.330527323797143 no 2237 0.331572323465883 3237 708907
SGTC_134 0269-0018 6.916 µM -0.43636006628147 0.330244619306195 no 2238 0.33128775383215 3204 4378915
SGTC_2235 salicylic acid 500 µM -0.436902198546904 0.330049292928387 no 2239 0.33109113871694 3235 338 A COX inhibitor and kinase inhibitor.
SGTC_1768 st044301 37.178 µM -0.436979618593727 0.330021402817626 no 2240 0.331063064586209 3205 3931349
SGTC_895 0964-0006 13.7 µM -0.437109534913438 0.329974603360039 no 2241 0.331015956341441 3294 6738897
SGTC_661 1304-0007 33.6 µM -0.437445704174413 0.329853518231019 no 2242 0.330894072266118 3209 3117130
SGTC_521 r062-0005 13.8 µM -0.437816131008569 0.329720114478618 no 2243 0.33075978826094 3185 2832033
SGTC_387 norethindrone acetate 66.7 µM -0.438923451202588 0.329321458675634 no 2244 0.330358501805758 3199 541197
SGTC_2278 7948257 134.34 µM -0.439246584372587 0.329205161280433 no 2245 0.330241436942718 3271 1247028
SGTC_2448 5185112 27.17 µM -0.439640675315242 0.329063348162295 no 2246 0.330098687947287 3279 5718189
SGTC_309 k408-0051 1.48 µM -0.440035356089383 0.32892134744623 no 2247 0.329955750086916 3243 3640463
SGTC_1378 2093-0007 380 nM -0.440216395911365 0.32885622006583 no 2248 0.329890192883877 3267 3618014
SGTC_233 rapamycin 362 pM -0.440427456396483 0.328780299593293 no 2249 0.329813771349678 3256 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1699 st031318 29.054 µM -0.441279006063954 0.328474060827619 no 2250 0.329505511379956 3272 5340658
SGTC_1847 st056231 15 µM -0.441690158765254 0.328326241154962 no 2251 0.329356716037029 3160 5393180
SGTC_1142 3253-1408 9.78 µM -0.442031876457285 0.328203405550692 no 2252 0.32923306964462 3303 256655
SGTC_10 0279-0212 42.575 µM -0.44244763267736 0.328053980722074 no 2253 0.329082658495313 3210 39851 YBR002C RER2
SGTC_369 0957-0393 4.5 µM -0.444874974523162 0.327182132048054 no 2254 0.328205054342952 3230 6997992
SGTC_3164 9100705 49.47 µM -0.446431753080928 0.326623466397875 no 2255 0.327642700163693 3311 17174235
SGTC_1937 st074714 47.2 µM -0.447676831127781 0.326176937183335 no 2256 0.327193222509435 3165 17250970
SGTC_2198 6589944 200 µM -0.448057610905385 0.326040425736425 no 2257 0.327055809626918 3250 5290268
SGTC_1980 st071811 45.7 µM -0.449152213814909 0.325648135013551 no 2258 0.326660928340112 3343 4974850
SGTC_1463 k081-0032 34.1 µM -0.450963806639943 0.324999309108133 no 2259 0.326007817403429 3249 977755
SGTC_938 3126-1755 342 µM -0.45278273940497 0.324348387930088 no 2260 0.325352596887258 3336 1777771
SGTC_2186 6124449 200 µM -0.452860209378303 0.324320676510345 no 2261 0.325324702423342 3296 3834182 YLR033W RSC58
SGTC_1171 0368-0077 21.4 µM -0.453790393275732 0.32398802081987 no 2262 0.324989849356385 3168 3239779
SGTC_1753 st043925 64 µM -0.454887732795965 0.323595766995965 no 2263 0.324595004331396 3284 670181
SGTC_690 glyoxal 20.3 µM -0.455579090110821 0.32334873571133 no 2264 0.32434634109672 3268 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3076 9116187 49.47 µM -0.455806824226689 0.323267380284827 no 2265 0.324264448202988 3277 27241210
SGTC_142 0335-0849 62.6745 µM -0.456162076906993 0.323140487174319 no 2266 0.324136716771921 3361 3889043 YPR107C YTH1
SGTC_3117 9124945 49.47 µM -0.456488840560425 0.323023788259515 no 2267 0.324019246871009 3157 17592065
SGTC_728 3030-5151 22.5 µM -0.45830570285727 0.322375240107129 no 2268 0.323366413772019 3208 3125388
SGTC_3048 9093155 49.47 µM -0.459703886736153 0.321876511346717 no 2269 0.322864389662342 3319 25236002
SGTC_539 4859-0462 2.54 µM -0.459752648288685 0.32185912400272 no 2270 0.322846887427621 3325 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2320 7373003 200 µM -0.459924639829777 0.321797798551182 no 2271 0.322785156752536 3268 5415828
SGTC_480 am 92016 50 µM -0.462285832787506 0.320956380910927 no 2272 0.321938178917708 3262 2129 K+ channel blocker.
SGTC_73 0327-0325 16.231 µM -0.463618960911942 0.320481722468132 no 2273 0.321460383626038 3283 53298
SGTC_2310 7668677 200 µM -0.465463526292158 0.319825451529188 no 2274 0.320799775354213 3402 2197143
SGTC_265 mycophenolic acid 32.932 µM -0.466539577053858 0.319442867638359 no 2275 0.320414662807052 3447 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2021 4019055 173 µM -0.466617761937176 0.319415076918268 no 2276 0.320386688402748 3368 44827708 YER133W GLC7
SGTC_244 nsc-207895 1.295 µM -0.466704593945352 0.31938421377718 no 2277 0.320355621269534 3201 42640
SGTC_953 1188-0045 9.7 µM -0.467612848179394 0.319061463398894 no 2278 0.320030737613293 3321 6144426
SGTC_2217 6934799 96.0675 µM -0.468605696070919 0.318708809324204 no 2279 0.319675752533099 3296 675606
SGTC_2199 6590217 200 µM -0.468960920537915 0.318582675407419 no 2280 0.319548784866711 3244 703109
SGTC_3335 9143315 29.6265 µM -0.469343061176056 0.318447007504304 no 2281 0.319412220183739 3229 4899691
SGTC_21 0849-0113 22.993 µM -0.469873006960867 0.318258905975731 no 2282 0.319222875266015 3252 1560156
SGTC_416 estradiol valerate 100 µM -0.470560584614946 0.318014923661558 no 2283 0.318977280150407 3305 13791 A steroid.
SGTC_2753 fluvastatin 17.09 µM -0.47069015714767 0.317968954557358 no 2284 0.318931007172094 3281 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2584 androsterone 48.74 µM -0.47076236284059 0.317943338994574 no 2285 0.318905222279738 3320 2754130 A steroid.
SGTC_652 0437-0092 114 µM -0.472082345958186 0.31747521775207 no 2286 0.318434006501022 3277 3091274
SGTC_663 1486-0733 13.9 µM -0.47259620501443 0.317293060683149 no 2287 0.318250645245488 3224 722445 YPR165W RHO1
SGTC_1407 3909-7909 12.3 µM -0.472619132964041 0.317284934022127 no 2288 0.31824246486114 3275 4411780
SGTC_3323 9138564 53.9225 µM -0.473089030491186 0.317118401340416 no 2289 0.318074831266731 3379 43912313 YNL103W MET4
SGTC_146 3448-8650 53.125 µM -0.473568405322954 0.316948548039009 no 2290 0.31790385508769 3241 2891488 YIL048W NEO1
SGTC_700 3453-2283 142 µM -0.473971611674033 0.316805712807409 no 2291 0.317760075581454 3382 565664
SGTC_2807 7945238 51.95 µM -0.474153891233689 0.316741149513359 no 2292 0.317695085460683 3292 17148797
SGTC_283 0987-0079 11.7 µM -0.475531877282498 0.316253248515072 no 2293 0.317203958902556 3331 411556
SGTC_51 1013-0126 23.419 µM -0.477116136143666 0.315692707984164 no 2294 0.316639712473097 3478 1627850
SGTC_2767 sibutramine 71.45 µM -0.477760450841685 0.315464858469216 no 2295 0.316410356546933 3421 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3020 9089140 49.47 µM -0.478085908580505 0.315349793251988 no 2296 0.316294530577729 3351 17217859
SGTC_1958 st076513 41.9 µM -0.480265148476327 0.3145797872632 no 2297 0.315519433607717 3219 732122 YGL099W LSG1
SGTC_205 1486-1330 71.903 µM -0.480857443802489 0.314370646554756 no 2298 0.315308910115655 3283 4118834
SGTC_3204 9114183 49.47 µM -0.481056802283822 0.314300266057428 no 2299 0.315238064278669 3182 17027248
SGTC_1733 st037357 54.9 µM -0.481859536392541 0.314016941254426 no 2300 0.314952866186668 3148 1272339 YGL099W LSG1
SGTC_780 0109-0199 192 µM -0.482281925147099 0.313867903242318 no 2301 0.314802842757604 3388 610414
SGTC_3242 9133940 49.47 µM -0.482365177230363 0.313838531692528 no 2302 0.314773277007056 3370 17248444
SGTC_693 4161-2696 114 µM -0.482499163126224 0.313791263599778 no 2303 0.314725696383679 3325 805759
SGTC_1038 k292-0204 154 µM -0.482875239219177 0.313658606265805 no 2304 0.314592161934214 3237 4454212
SGTC_2297 7971671 152.32 µM -0.484770254285479 0.312990524205488 no 2305 0.31391966255048 3382 909016
SGTC_516 3992-2719 87.3 µM -0.484868690554341 0.312955837530718 no 2306 0.313884746527738 3147 5350887 YDR037W KRS1
SGTC_731 3966-0296 387 µM -0.486552038379605 0.312362920967771 no 2307 0.313287909589898 3266 660956
SGTC_1063 disulfiram 1.84 µM -0.486868977200592 0.31225134157406 no 2308 0.313175592428678 3292 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_925 2064-1272 59.6 µM -0.487715636330631 0.311953356787604 no 2309 0.312875637352407 3258 6815817
SGTC_2859 9028643 45.46 µM -0.488436938284844 0.311699588961514 no 2310 0.312620191599946 3299 17151580
SGTC_2778 tioconazole 65.09 nM -0.489377505975797 0.311368813548323 no 2311 0.312287229082861 3310 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_768 0384-0033 77.3 µM -0.491067381049103 0.310774907006362 no 2312 0.311689395611965 3249 3965305 YMR134W ERG29
SGTC_13 0199-0087 65 µM -0.492452415561768 0.310288503946988 no 2313 0.311199776461666 3357 4589825
SGTC_1831 st055328 12 µM -0.493556020227374 0.309901172124251 no 2314 0.310809883626824 3373 1103068
SGTC_1412 3909-8563 178 µM -0.493722215850413 0.309842860755048 no 2315 0.310751186708714 3387 23767530
SGTC_1770 st043884 66.3 µM -0.493953482150413 0.309761726659226 no 2316 0.310669516163354 3328 670149
SGTC_1177 0983-0204 23.6 µM -0.493959199151682 0.309759721107236 no 2317 0.310667497350893 3379 766818
SGTC_2106 5357045 167.29 µM -0.494389437766085 0.30960880755067 no 2318 0.31051558597394 3316 668842
SGTC_3245 9134821 49.47 µM -0.49554782327707 0.309202643593011 no 2319 0.310106736536049 3265 17014901
SGTC_2693 st077581 40.7 µM -0.495657173778355 0.309164314129798 no 2320 0.310068153647379 3372 25238761
SGTC_2495 cafestol 54.53 µM -0.495728704999717 0.309139242178556 no 2321 0.310042915926431 3407 16667697 An anti-infammatory.
SGTC_3083 9117465 49.47 µM -0.497221929550173 0.308616064684569 no 2322 0.309516279343413 3338 16420915
SGTC_2725 haloperidol 53.21 µM -0.497778056280592 0.308421315071419 no 2323 0.309320242123972 3274 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_554 4483-2211 187 µM -0.499672265979212 0.307758387833502 no 2324 0.308652931963356 3317 747107
SGTC_1695 st026914 34.495 µM -0.500333933342154 0.307526968051381 no 2325 0.308419982191234 3285 3289191
SGTC_1028 k015-0029 4.8 µM -0.501783159851175 0.307020365184617 no 2326 0.307910030081551 3316 4588309
SGTC_759 3486-0358 89.3 µM -0.501795253919375 0.307016139036185 no 2327 0.307905775993718 3428 875103
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.501941341397653 0.306965092286647 no 2328 0.307854391770678 3314 2333 A French combination drug.
SGTC_568 1193-0097 7.48 µM -0.501980963775297 0.306951247846463 no 2329 0.307840455804153 3306 3646150
SGTC_2398 5228213 48.84 µM -0.502303134173869 0.306838688628137 no 2330 0.307727152453761 3443 80771 YMR134W ERG29
SGTC_2755 lomerizine 42.69 µM -0.50460929243441 0.306033500069396 no 2331 0.306916640937121 3298 3949 A calcium channel blocker.
SGTC_1945 st075991 56.6 µM -0.506379237985843 0.30541616342536 no 2332 0.306295223407321 3297 1084980
SGTC_506 n9-isopropylolomoucine 153 µM -0.506726755455434 0.305295018215194 no 2333 0.3061732773944 3402 6610355
SGTC_1361 1608-0041 5.61 µM -0.509155299739936 0.304449019112254 no 2334 0.305321686247052 3326 X1361
SGTC_1053 3366-3204 134 µM -0.510484591243151 0.303986394122544 no 2335 0.304856003501459 3309 3632071 YPR165W RHO1
SGTC_1196 1588-0294 184 µM -0.512172236586425 0.303399505489115 no 2336 0.304265235992534 3341 6144269
SGTC_2189 6047310 154.431 µM -0.512329991496871 0.30334467117063 no 2337 0.30421003927464 3314 711535
SGTC_882 0843-0131 351 µM -0.513578019125832 0.302911023174283 no 2338 0.303773525382725 3419 5425421
SGTC_2505 galangin 7.89 µM -0.514165714765126 0.302706914681077 no 2339 0.303568068026108 3267 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1336 1486-0901 104 µM -0.514317317774257 0.302654272490506 no 2340 0.303515077951751 3369 5006114
SGTC_792 4534-1957 155 µM -0.515072783722608 0.3023920078513 no 2341 0.303251080180546 3300 1717904
SGTC_2551 apiole 73.87 µM -0.516201513586577 0.302000352387818 no 2342 0.302856836633267 3296 10659 A possible DNA adduct former.
SGTC_1113 artemisinin 1.17947 µM -0.517704914785468 0.301479044701164 no 2343 0.302332084317826 3401 2240 An anti-malaria and mitochondrial poison.
SGTC_1216 1165-0504 9.65 µM -0.518317248740613 0.301266832670645 no 2344 0.302118470130067 3425 6304004
SGTC_1103 duloxetine 36.1 µM -0.518579023131196 0.301176131996636 no 2345 0.302027170178417 3425 60835 A selective serotonin reuptake inhibitor.
SGTC_3355 9151058 44.0485 µM -0.518946337704124 0.301048884069896 no 2346 0.301899081511903 3403 17015728
SGTC_2130 NSC 7 2.4545 µM -0.519318981573339 0.300919814695725 no 2347 0.301769159379075 3392 21448
SGTC_3040 9091894 49.47 µM -0.519595785680927 0.300823956650758 no 2348 0.301672668012293 3309 25236966
SGTC_1098 clofazimine 15.1 µM -0.521310664997916 0.300230396369159 no 2349 0.301075186354194 3431 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3159 9100096 49.47 µM -0.52282260772633 0.299707516864483 no 2350 0.300548852724268 3345 25236875
SGTC_3265 9137266 49.47 µM -0.52336354729917 0.299520542414024 no 2351 0.300360643196549 3356 17224265
SGTC_3089 9117425 49.47 µM -0.526331985625044 0.298495451398705 no 2352 0.299328781534036 3369 9401657
SGTC_1023 4482-3888 16 µM -0.526925137175118 0.298290809817812 no 2353 0.299122788455938 3442 3303168
SGTC_70 0141-0289 43.283 µM -0.527217569061885 0.298189942213423 no 2354 0.299021254718441 3334 352408
SGTC_3235 9132602 49.47 µM -0.527601092939177 0.298057678090077 no 2355 0.298888117136858 3450 4912240
SGTC_1186 1319-0216 26 µM -0.528218799757246 0.29784470858963 no 2356 0.298673741253169 3466 4565136
SGTC_60 0986-0278 202 µM -0.528771687617112 0.297654145881973 no 2357 0.298481920177071 3271 3110598
SGTC_2411 st077133 39.94 µM -0.528901828651169 0.29760929853355 no 2358 0.298436776688685 3537 1403142 YNL221C POP1
SGTC_418 lividomycin a 100 µM -0.53029862298082 0.297128149490038 no 2359 0.297952450639981 3439 72394 An antibiotic.
SGTC_1692 fluoroquinolonic acid 71 µM -0.530895239521171 0.296922743452631 no 2360 0.297745688406933 3424 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1180 1193-0155 285 µM -0.531422513875594 0.296741264980592 no 2361 0.297563011767534 3422 2921347
SGTC_2779 methotrexate 400 µM -0.531861497925698 0.296590213215448 no 2362 0.297410962753458 3451 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1050 3232-1156 69.3 µM -0.533103585538145 0.296163009302464 no 2363 0.296980938593291 3343 700529
SGTC_1242 0402-0103 60.1 µM -0.534187220243899 0.295790534472022 no 2364 0.296606005024014 3362 432868
SGTC_627 1391-0720 175 µM -0.537066330109348 0.294801952831371 no 2365 0.295610898639836 3368 997839
SGTC_1497 4476-2978 41.3 µM -0.539190616302042 0.294073528183073 no 2366 0.294877667253787 3427 1528379
SGTC_394 menadione 8.33 µM -0.539714583645308 0.293893986062501 no 2367 0.294696940495983 3426 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3138 9097216 49.47 µM -0.542964194790798 0.292781611534284 no 2368 0.293577227576882 3447 25237486
SGTC_567 1080-0542 68.4 µM -0.543273226430061 0.292675928773133 no 2369 0.293470847728807 3419 5950415
SGTC_1638 st008370 60.6 µM -0.54384405486375 0.292480763249046 no 2370 0.293274394936952 3427 24207134
SGTC_799 1310-0557 151 µM -0.545204981281331 0.292015708412655 no 2371 0.292806272970829 3470 5354492
SGTC_2147 5545932 89.7195 µM -0.546569169100423 0.291549884886661 no 2372 0.292337377630247 3405 797404
SGTC_978 1416-0512 87.4 µM -0.546795735992567 0.291472553600911 no 2373 0.292259536431008 3434 6814003
SGTC_275 trichlorophene 5.69 µM -0.546948511950009 0.291420413867146 no 2374 0.292207052900074 3439 62616
SGTC_179 1273-0063 6.77 µM -0.547252021127284 0.2913168444607 no 2375 0.292102800596042 3327 3108139
SGTC_2977 9011197 71.43 µM -0.549820560881831 0.290441045122867 no 2376 0.291221227367659 3497 2704722
SGTC_2192 5915882 198.485 µM -0.550682016974944 0.290147589235992 no 2377 0.290925837138237 3395 2876149
SGTC_384 k007-0144 5.16 µM -0.550804625207781 0.290105833914909 no 2378 0.290883806596562 3398 6824886
SGTC_1844 rapamycin 4 nM -0.551369934354254 0.289913349307017 no 2379 0.290690053314849 3409 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2144 5628481 200 µM -0.55159693310698 0.289836074356408 no 2380 0.290612269062453 3387 2818399
SGTC_3030 9087619 49.47 µM -0.552199673450277 0.2896309362973 no 2381 0.290405779042121 3385 25236973
SGTC_2655 perillic acid 100 µM -0.554349143170595 0.288899936222031 no 2382 0.289669962005146 3371 5702197 An apoptosis inducer.
SGTC_1182 1222-0449 220 µM -0.555611692415977 0.288470968700528 no 2383 0.289238168293266 3424 658318
SGTC_769 0302-0231 76 µM -0.557431081723881 0.287853336042038 no 2384 0.288616467135762 3473 571869 YER009W NTF2
SGTC_2663 amphotericin b 100 µM -0.559649539147122 0.287101076876842 no 2385 0.287859253773998 3442 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_26 0302-0163 425.158 µM -0.560717526001173 0.286739264269879 no 2386 0.287495058806365 3410 3100915
SGTC_2316 5844804 197.44 µM -0.561207456562331 0.286573357942857 no 2387 0.287328060166015 3441 776813
SGTC_2746 daunorubicin 9.88 µM -0.562940664427102 0.285986803488759 no 2388 0.286737644395797 3372 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2619 obliquin 87.91 µM -0.563118679719929 0.2859265916496 no 2389 0.286677036224647 3455 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2647 atorvastatin 60.16 µM -0.563282035364485 0.285871343588447 no 2390 0.286621424512061 3447 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3027 9089541 49.47 µM -0.564028979937617 0.285618786215909 no 2391 0.286367204859197 3480 9943819
SGTC_848 0368-0089 85.6 µM -0.565156301241288 0.285237816799363 no 2392 0.285983728269299 3457 762535
SGTC_2264 7948757 110.76 µM -0.565646789317736 0.285072135815263 no 2393 0.285816957042138 3378 2971411
SGTC_3272 9137413 49.47 µM -0.567016002562425 0.284609874978579 no 2394 0.28535165471108 3430 17614870
SGTC_1660 st012960 28.1 µM -0.567151976679873 0.284563988225854 no 2395 0.285305466070389 3431 24207266
SGTC_2679 rapamycin 1 nM -0.568779736097268 0.284014947922363 no 2396 0.284752814051627 3470 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_249 wiskostatin 11.211 µM -0.56903674159276 0.283928306783484 no 2397 0.284665603036716 3473 2775510 A n-wasp and actin depolymerizer.
SGTC_1973 st070275 50.2 µM -0.569224976011963 0.283864857627482 no 2398 0.284601736560471 3432 17118334
SGTC_3336 9143619 71.43 µM -0.570294126282748 0.283504602390693 no 2399 0.284239112034918 3502 45595730
SGTC_2389 9091542 195.52 µM -0.571831265720138 0.282987040284985 no 2400 0.283718146671291 3410 3626624 YOL127W RPL25
SGTC_2286 7945697 125 µM -0.572363986600453 0.282807776549626 no 2401 0.283537704341856 3422 1245733
SGTC_3056 9094900 49.47 µM -0.572379212330834 0.282802653802967 no 2402 0.283532547916248 3396 25236784
SGTC_2699 st077704 54.6 µM -0.573776988794258 0.28233255733419 no 2403 0.283059361147706 3444 645852
SGTC_637 1181-0519 7.26 µM -0.574223127960934 0.282182592181584 no 2404 0.282908410286107 3485 6252091 YGR060W ERG25
SGTC_2552 juarezic acid 87.02 µM -0.5746610688498 0.282035420098901 no 2405 0.282760270912592 3514 1549512
SGTC_2239 6685329 187.64 µM -0.575477105553274 0.281761285803035 no 2406 0.282484335023069 3484 805680
SGTC_604 1000-0114 314 µM -0.57631454893735 0.281480093881452 no 2407 0.282201295341419 3511 1572745
SGTC_3287 9117173 37.0625 µM -0.576455078547455 0.281432920926793 no 2408 0.282153812426799 3421 2789709
SGTC_2666 tannic acid 100 µM -0.576498203814526 0.281418445409766 no 2409 0.282139241796547 3505 16134267 A thiamine antagonist.
SGTC_286 k060-0067 22.9 µM -0.576768268374943 0.281327803147523 no 2410 0.282048003971141 3429 5985051
SGTC_803 4488-1585 147 µM -0.578655772086704 0.280694690570074 no 2411 0.28141073218759 3469 747204
SGTC_3246 9135460 32.98 µM -0.579095938497707 0.28054714769233 no 2412 0.281262220197588 3441 41446951
SGTC_397 arbidol 50 µM -0.579973451548771 0.280253119160207 no 2413 0.280966260572777 3523 131410 A RNA synthesis inhibitor.
SGTC_251 melphalan 456.522 µM -0.580777410790995 0.279983867418127 no 2414 0.280695240685621 3495 460612 A DNA alkylator.
SGTC_359 0081-0058 15.9 µM -0.581813300850688 0.279637125388314 no 2415 0.280346221955391 3638 3494159
SGTC_22 0964-0034 14.468 µM -0.583567520942756 0.279050413523878 no 2416 0.279755658571179 3475 138402
SGTC_643 k048-0106 28.4 µM -0.583941977109107 0.278925251467851 no 2417 0.279629675012753 3503 6763920
SGTC_969 1313-0238 134 µM -0.58526090551594 0.278484616998072 no 2418 0.27918614881549 3443 5212874
SGTC_3271 9137798 49.47 µM -0.585743902556978 0.278323339709525 no 2419 0.279023813271025 3461 6498326
SGTC_950 1165-0508 94.1 µM -0.587404275059789 0.277769273111407 no 2420 0.278466111663349 3456 6148369
SGTC_3263 9137018 49.47 µM -0.590436621691977 0.27675877069096 no 2421 0.277448982254003 3456 43844957
SGTC_485 niflumic acid 177 µM -0.59252794886041 0.276062905526809 no 2422 0.276748555460913 3515 4488 A COX2 inhibitor.
SGTC_1295 1013-0063 9.78 µM -0.592739514773788 0.275992557269376 no 2423 0.276677746136508 3521 6826038
SGTC_1793 st048256 72.231 µM -0.593795713187789 0.275641490101252 no 2424 0.276324378299904 3477 672022
SGTC_409 arachidonic acid 100 µM -0.595009770176772 0.27523822413038 no 2425 0.275918470097702 3509 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_380 3970-0968 6 µM -0.595845682415377 0.274960733148303 no 2426 0.275639161295072 3465 2891601
SGTC_3329 9141233 27.5565 µM -0.596503124090237 0.274742584469341 no 2427 0.27541958372855 3542 4909101 YNL103W MET4
SGTC_2955 9076254 12.21 µM -0.596617830676694 0.274704531906084 no 2428 0.275381281935513 3447 16459619
SGTC_1194 1488-0194 225 µM -0.596868865608084 0.274621263083685 no 2429 0.275297467751651 3487 1391452
SGTC_2805 7950783 58.44 µM -0.598260988960514 0.274159718876585 no 2430 0.274832901143296 3491 1178958 YDL195W SEC31
SGTC_3230 9131665 49.47 µM -0.598873474171736 0.273956777136038 no 2431 0.274628630685643 3451 15943720
SGTC_738 1315-0003 72.4 µM -0.598889766438221 0.273951379846772 no 2432 0.274623198060789 3532 6251474
SGTC_3332 9141069 11.198 µM -0.599007832060781 0.273912268730497 no 2433 0.274583830890497 3484 17332883
SGTC_2638 epoxomicin 18 µM -0.599490075541922 0.273752546572221 no 2434 0.274423063114221 3497 9915668 A protesome inhibitor.
SGTC_2004 4023728 41.89 µM -0.601226580029989 0.273177786926069 no 2435 0.27384454157299 3520 360084 YDR527W RBA50
SGTC_2661 dactinomycin 12.96 µM -0.601796074185097 0.272989422301489 no 2436 0.273654944331713 3524 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2769 toremifene 3.73 µM -0.602073941648887 0.272897538855296 no 2437 0.273562459667459 3570 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1702 st027038 51 µM -0.603460977357752 0.272439112193264 no 2438 0.273101033860506 3520 5521182
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.604467461749699 0.272106700481618 no 2439 0.27276644791345 3543 5377381
SGTC_1644 st010134 20.9 µM -0.604735561732806 0.272018189091794 no 2440 0.272677357658795 3514 3818134
SGTC_2114 5491910 81.25 µM -0.605537409313581 0.271753550032589 no 2441 0.272410988034924 3563 2849228
SGTC_1583 clindamycin 39.6 µM -0.606187972250087 0.271538934641097 no 2442 0.272194969395015 3456 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_648 0375-0473 33.3 µM -0.606435894961794 0.271457169185985 no 2443 0.272112669367994 3530 1713139
SGTC_770 0389-1121 67.2 µM -0.606556570290982 0.271417374635704 no 2444 0.272072614655344 3594 6753108
SGTC_2335 9018011 154.17 µM -0.607080239639997 0.271244720274112 no 2445 0.271898831612138 3514 6458208
SGTC_2629 bisabolol 100 µM -0.607105563017265 0.271236372516689 no 2446 0.271890429286383 3554 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1021 4476-0760 85.3 µM -0.607640859395771 0.271059944022395 no 2447 0.271712847561924 3442 746768
SGTC_2353 9059630 146.67 µM -0.608983862277645 0.270617555402476 no 2448 0.271267567784622 3518 4779114
SGTC_1529 apigenin 74 µM -0.610031032240398 0.27027286530052 no 2449 0.270920625546711 3607 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2213 7173844 200 µM -0.610191526794059 0.270220055762584 no 2450 0.270867471003092 3503 892728
SGTC_1001 4048-4355 44.4 µM -0.610776497222182 0.270027619287519 no 2451 0.2706737774302 3528 21824233
SGTC_296 1222-0039 74.9 µM -0.612339786879182 0.269513683946018 no 2452 0.270156485510406 3502 5984176
SGTC_229 benomyl 22.8748 µM -0.612830126662368 0.269352584583778 no 2453 0.269994334205253 3541 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_651 3253-0966 34.4 µM -0.612990678485229 0.269299846358092 no 2454 0.269941251633454 3511 781462
SGTC_601 0986-0029 62.9 µM -0.613859920171054 0.269014406910866 no 2455 0.269653948648875 3547 24747981
SGTC_2109 5483026 200 µM -0.613965114190304 0.268979873861122 no 2456 0.269619190167013 3530 759335
SGTC_1851 st056236 18.9 µM -0.61422861188645 0.268893382714223 no 2457 0.269532134426325 3579 5393171
SGTC_121 0557-0495 61.343 µM -0.614700488954419 0.268738527502665 no 2458 0.269376268432896 3614 3104427
SGTC_16 erodoxin 22.806 µM -0.614918785008027 0.268666904763675 no 2459 0.269304178226153 3568 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1006 4099-6547 255 µM -0.616828482608272 0.268040743954077 no 2460 0.268673931488302 3550 3146833
SGTC_2829 7992743 58.44 µM -0.620420351197769 0.266865018688614 no 2461 0.267490538630507 3499 16462845
SGTC_208 k072-0098 12.366 µM -0.620462611685835 0.266851201099991 no 2462 0.267476630964324 3555 5948901
SGTC_1462 k081-0014 26.5 µM -0.620690778268719 0.266776605462058 no 2463 0.267401549047851 3382 3270634
SGTC_236 1509-0011 5.31 µM -0.620898621534043 0.26670866340088 no 2464 0.26733316410275 3621 3107280
SGTC_1487 3970-0795 2.82 µM -0.62106099341117 0.266655591606471 no 2465 0.267279746370909 3573 3765103
SGTC_783 0848-0141 92.7 µM -0.621592601342035 0.266481871128514 no 2466 0.267104893617511 3552 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_991 3996-0057 64.7 µM -0.621720513923715 0.266440080006855 no 2467 0.267062830129194 3536 715343
SGTC_1199 1638-0010 4.46 µM -0.621879381464756 0.266388180012893 no 2468 0.26701059189626 3495 3111136
SGTC_2891 9063876 19.48 µM -0.621907787084779 0.266378900799188 no 2469 0.267001252209955 3492 6472478
SGTC_2911 7942208 15.64 µM -0.62200438961162 0.266347345046332 no 2470 0.266969490811185 3521 1243384
SGTC_2471 5466956 24.79 µM -0.622008299793183 0.266346067803604 no 2471 0.266968205244876 3488 724419
SGTC_2011 4012611 177 µM -0.624244911990966 0.265615997055753 no 2472 0.266233377916595 3542 2049887
SGTC_1108 betulinic acid 729.144 nM -0.625033693165721 0.265358766875374 no 2473 0.265974472383223 3554 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3142 9086498 49.47 µM -0.626289830754282 0.264949387808084 no 2474 0.265562427619749 3484 25236367
SGTC_849 0386-0493 241 µM -0.627240201786169 0.264639872399018 no 2475 0.265250897284048 3490 726119
SGTC_1701 st028638 40.4 µM -0.627678139255584 0.264497307508157 no 2476 0.265107404450588 3551 3490878
SGTC_1722 st034304 3.6505 µM -0.627754468464765 0.264472463519223 no 2477 0.265082398763743 3540 4036148 YLR033W RSC58
SGTC_1263 0774-1208 64.8 µM -0.629446074670391 0.263922176561507 no 2478 0.26452853097042 3610 906585
SGTC_2960 9079389 5.97 µM -0.629553927794949 0.263887111266728 no 2479 0.264493237545473 3558 16457355
SGTC_565 1418-0001 44.5 µM -0.629933986686793 0.263763565146999 no 2480 0.264368887696394 3595 2862145
SGTC_278 4092-0821 23.9 µM -0.630114305474334 0.263704959059787 no 2481 0.264309900372003 3564 877900
SGTC_2616 abietic acid 100 µM -0.630199109157846 0.26367739899228 no 2482 0.264282161029618 3585 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_670 4204-0025 119 µM -0.630352834360557 0.263627444095055 no 2483 0.264231881190881 3543 719039
SGTC_1206 3978-0017 132 µM -0.631016152644895 0.26341194603369 no 2484 0.264014981513061 3625 3873677
SGTC_2586 curcumin 80 µM -0.631063949480064 0.2633964213285 no 2485 0.263999355842335 3563 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1838 st055369 84.5 µM -0.632349868883662 0.262978922234752 no 2486 0.263579141951093 3543 676036
SGTC_2079 5212404 121 µM -0.63388548082198 0.262480799088297 no 2487 0.263077780825856 3589 758462
SGTC_715 0868-0130 184 µM -0.634298616937751 0.262346868135253 no 2488 0.262942979475472 3625 2876258
SGTC_602 3130-1533 38.1 µM -0.635571376323621 0.261934483601501 no 2489 0.26252791545739 3594 720941
SGTC_2795 7780010 54.55 µM -0.635823586402356 0.261852804933003 no 2490 0.262445706176055 3555 953673
SGTC_2796 7949634 45.45 µM -0.638290605831579 0.261054545831447 no 2491 0.261642263020678 3559 2971588
SGTC_303 1348-1668 34.2 µM -0.638586527568689 0.260958877860593 no 2492 0.261545973973042 3570 5380509
SGTC_2708 st078559 56 µM -0.639867435994458 0.260544983444724 no 2493 0.261129393076529 3527 17250902
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.640098341602076 0.26047040788298 no 2494 0.261054333555051 3553 756377
SGTC_2099 5377090 177.372 µM -0.641004918580509 0.260177717143427 no 2495 0.260759743662 3553 2243829
SGTC_1587 estradiol valerate 56.1 µM -0.641463659488782 0.260029676064362 no 2496 0.260610742167573 3609 13791 A steroid.
SGTC_2998 9066762 71.4286 µM -0.642743308437831 0.259616948007946 no 2497 0.260195337127105 3631 4945196
SGTC_2181 6316240 54.2555 µM -0.642874346320419 0.259574703162084 no 2498 0.260152818326999 3561 12779990
SGTC_1534 6-azauridine 81.6 µM -0.643224968176366 0.259461684861514 no 2499 0.260039067157147 3594 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_477 mead ethanolamide 10 µM -0.644025398324268 0.259203772100939 no 2500 0.259779482201539 3471 16061185
SGTC_1971 st069429 63.5 µM -0.644293417343359 0.259117441253621 no 2501 0.259692591698654 3578 1246522 YGL099W LSG1
SGTC_1917 st066507 28.5 µM -0.64448388552624 0.259056099123941 no 2502 0.259630851930709 3529 3156428
SGTC_2861 9024595 19.48 µM -0.645397598081271 0.258761933567073 no 2503 0.259334779774072 3532 16482810
SGTC_2143 5623677 140.463 µM -0.645863080199451 0.258612140235986 no 2504 0.259184015747599 3573 5375313
SGTC_1125 tnp00248 1.32998 µM -0.647355829157637 0.258132072856646 no 2505 0.258700838210939 3644 24207736
SGTC_1143 3454-2408 5.08 µM -0.647643249728832 0.25803969161081 no 2506 0.25860785860427 3556 X1143
SGTC_1243 0416-0003 5.65 µM -0.647760983735243 0.258001855101405 no 2507 0.258569777037721 3560 2141977
SGTC_2643 anethole 100 µM -0.64817273131515 0.257869553255547 no 2508 0.25843661836702 3580 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2461 5755302 26.15 µM -0.649630807875291 0.257401330450674 no 2509 0.257965363963153 3608 2788904
SGTC_328 k915-0120 63.5 µM -0.649814245054151 0.257342455741092 no 2510 0.257906108140688 3575 6624543
SGTC_872 0588-0139 234 µM -0.651819168858134 0.256699426008006 no 2511 0.257258917105967 3621 2047100
SGTC_181 1447-1644 8.07 µM -0.652145338250761 0.256594894414986 no 2512 0.257153709258788 3561 534600
SGTC_2968 9090663 33.37 µM -0.652329858373344 0.25653576875851 no 2513 0.257094201122552 3550 25236811
SGTC_1661 st013063 9.66 µM -0.653464300503398 0.256172416242586 no 2514 0.256728498523726 3630 721395
SGTC_1418 3966-3099 2.4 µM -0.653607752160917 0.256126488972577 no 2515 0.256682274257902 3597 740335
SGTC_2437 5741531 144.16 µM -0.654719363371176 0.255770742791089 no 2516 0.256324227982194 3666 2262990
SGTC_674 0498-0004 451 µM -0.654773823803608 0.255753320584536 no 2517 0.256306693149481 3560 4231473
SGTC_933 2914-0560 114 µM -0.655617809576374 0.255483403885744 no 2518 0.256035031784685 3629 463887
SGTC_1205 4161-2785 76 µM -0.655624913176891 0.25548113270151 no 2519 0.25603274592187 3570 3498106
SGTC_159 3970-0959 50 µM -0.656617715924176 0.255163814654573 no 2520 0.25571337734321 3700 6615653
SGTC_1357 1503-1303 39.5 µM -0.656779679295568 0.255112067738953 no 2521 0.255661296088812 3613 292895
SGTC_2354 9060492 162 µM -0.657980305341288 0.254728641766062 no 2522 0.255275393255718 3610 6471895
SGTC_1016 4226-1401 38 µM -0.658230411646623 0.254648807050314 no 2523 0.255195042927044 3607 2901613
SGTC_1105 epirubicin 18.1 µM -0.658333153615826 0.25461601528966 no 2524 0.255162039391099 3565 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1308 1187-1617 41.4 µM -0.658482269848419 0.254568426367788 no 2525 0.255114143141964 3608 2882570
SGTC_2808 7946468 45.46 µM -0.658793501375079 0.254469115019642 no 2526 0.255014190486726 3595 2970879
SGTC_3149 9097855 49.47 µM -0.660656627244184 0.253875032089928 no 2527 0.254416272417979 3602 25236625 YMR079W SEC14
SGTC_1849 st056239 19.2 µM -0.661113347170634 0.253729511931199 no 2528 0.254269813153832 3540 5393181
SGTC_3111 9122088 49.47 µM -0.661412223705387 0.253634307567688 no 2529 0.25417399446096 3535 16876704
SGTC_1720 st037298 9.481 µM -0.661804425197806 0.253509403871024 no 2530 0.254048284872311 3602 597396
SGTC_1354 1498-1681 81 µM -0.661840485751993 0.253497921354419 no 2531 0.254036728273822 3648 5754243
SGTC_2595 hexamethylquercetagetin 100 µM -0.663089657009432 0.253100325020047 no 2532 0.253636567235744 3557 386331
SGTC_511 blebbistatin 171 µM -0.664655613514118 0.252602363467016 no 2533 0.25313539487612 3668 3476986 A myosin inhibitor.
SGTC_2312 7706453 155.7 µM -0.665373363151079 0.252374297467554 no 2534 0.252905858817994 3644 976098
SGTC_2339 9000433 200 µM -0.665518434622917 0.252328213984214 no 2535 0.25285947832903 3580 2988954
SGTC_741 4582-0002 126 µM -0.66689645472445 0.251890692660132 no 2536 0.252419137833086 3594 2912688
SGTC_3000 9075062 71.4286 µM -0.667722276307205 0.25162868636041 no 2537 0.252155443842292 3608 17057871
SGTC_2917 7979103 53.79 µM -0.667852653479681 0.251587335090046 no 2538 0.252113826248992 3630 2980565
SGTC_1614 st002383 48.6 µM -0.668443396764348 0.251400016107917 no 2539 0.251925300967815 3629 1947235
SGTC_1666 st014829 29 µM -0.669717393945667 0.250996294973139 no 2540 0.25151898066759 3642 3858230
SGTC_800 3448-7362 155 µM -0.669801573292803 0.250969631192722 no 2541 0.251492145260076 3706 15991913
SGTC_830 4076-0286 57.8 µM -0.67241526381861 0.25014249193704 no 2542 0.250659684112027 3674 6866659
SGTC_813 k007-0158 173 µM -0.674490759476595 0.249486703493274 no 2543 0.249999679274407 3651 6523916
SGTC_3307 9126885 69.2785 µM -0.674490759476595 0.249486703493274 no 2544 0.249999679274407 3625 24824909
SGTC_3179 9107801 49.47 µM -0.675580182808721 0.249142847492275 no 2545 0.249653613527019 3641 4818259
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.677173835456558 0.248640295423958 no 2546 0.249147833217815 3513 88881 An O-methylated flavonoid and antioxidant.
SGTC_2191 5911152 200 µM -0.679035791252409 0.248053819662075 no 2547 0.248557592153387 3633 2875902
SGTC_1133 3473-0247 50 µM -0.679857466955178 0.247795244505747 no 2548 0.248297357591404 3626 711311
SGTC_3231 9132313 49.47 µM -0.680593340059788 0.24756379298674 no 2549 0.248064421100186 3648 4905967
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.681233143974788 0.247362651662727 no 2550 0.247861989554649 3603 279621
SGTC_1404 3909-7820 48.3 µM -0.68254004878661 0.24695205900748 no 2551 0.247448763973567 3621 23741373
SGTC_2814 7977482 42.97 µM -0.682568163940371 0.246943230027735 no 2552 0.247439878390143 3685 6456762
SGTC_1294 1000-1494 117 µM -0.682875157235787 0.246846836156337 no 2553 0.247342866559147 3627 712797 YDL207W GLE1
SGTC_2644 guaiazulene 100 µM -0.683688704649155 0.246591485071737 no 2554 0.247085878772329 3664 3515 A coloring agent.
SGTC_543 3844-1095 191 µM -0.68446691054807 0.246347359225769 no 2555 0.246840188577739 3651 4230703
SGTC_2269 7935389 174.42 µM -0.68483449090143 0.246232093077404 no 2556 0.246724183946341 3619 97605
SGTC_989 1501-0895 10.3 µM -0.684978332194215 0.246186995080467 no 2557 0.246678797041292 3643 2830112
SGTC_1978 st071761 42 µM -0.685661454775934 0.245972878815551 no 2558 0.246463309284009 3630 5147680
SGTC_642 0335-0876 158 µM -0.687139895340058 0.245509822380239 no 2559 0.245997287857065 3668 6812350
SGTC_2918 7977171 22.06 µM -0.687281024923336 0.245465644249806 no 2560 0.245952826925697 3608 2236483
SGTC_2182 6325192 200 µM -0.687664714731706 0.245345558508147 no 2561 0.245831972536529 3610 736248
SGTC_2377 9073351 62.6 µM -0.69002305170004 0.244608149391767 no 2562 0.245089845547712 3628 7337946 YHR072W ERG7
SGTC_1885 st057546 99.9 µM -0.690196799233223 0.244553868944931 no 2563 0.245035217966896 3712 702008
SGTC_2295 7971645 200 µM -0.690483931800313 0.244464180115292 no 2564 0.244944955604236 3659 2978226 YKL099C UTP11
SGTC_503 tyrphostin 8 294 µM -0.691388147637438 0.244181854753988 no 2565 0.244660825219703 3635 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_456 gingerol 170 µM -0.69268142089236 0.243778358845506 no 2566 0.244254750553476 3710 442793 A herb.
SGTC_1447 4239-0816 81.9 µM -0.69411080800209 0.243332815020208 no 2567 0.243806360560568 3656 1341554
SGTC_3310 9130229 44.1445 µM -0.694292394532331 0.243276245528887 no 2568 0.243749429798712 3698 7761258
SGTC_2841 9004761 38.96 µM -0.694524072941293 0.243204081280233 no 2569 0.243676804719209 3593 2991039
SGTC_2873 9040596 71.43 µM -0.69478261885021 0.2431235618856 no 2570 0.243595771182258 3657 6463863
SGTC_3004 9076122 71.4286 µM -0.696068283042718 0.242723379437408 no 2571 0.24319303412024 3641 44782551
SGTC_846 0335-0850 148 µM -0.697567846765298 0.242257068372906 no 2572 0.242723747738576 3664 6819598
SGTC_2884 9058502 51.95 µM -0.698280032460495 0.242035774092447 no 2573 0.242501042025308 3658 6471554
SGTC_2053 5265679 138 µM -0.69833996925163 0.242017155203621 no 2574 0.242482304399757 3653 764595
SGTC_1726 st035556 14.5795 µM -0.699395409686204 0.241689418313457 no 2575 0.242152477869065 3756 5919439
SGTC_2061 5245884 80.95 µM -0.699560892622204 0.24163805416953 no 2576 0.242100786299279 3666 573863
SGTC_1834 st055981 52.8 µM -0.700342989180698 0.241395379922917 no 2577 0.241856565360284 3706 471719 YDL150W RPC53
SGTC_717 1532-0246 73.2 µM -0.701445128883365 0.241053625383061 no 2578 0.241512633363639 3678 9561992
SGTC_1383 3049-0032 20.7 µM -0.701891345135252 0.240915336263997 no 2579 0.241373463391202 3709 712864
SGTC_2233 sulbentine 40.3845 µM -0.704139277543566 0.240219325002322 no 2580 0.240673020918365 3665 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2606 farnesol 9.78 µM -0.706149809639512 0.239597747801639 no 2581 0.240047489436845 3708 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2430 5571206 200 µM -0.706907109003539 0.239363848543032 no 2582 0.239812102933255 3719 1731771
SGTC_413 propylparaben 100 µM -0.707264386385111 0.239253543270293 no 2583 0.239701096429041 3658 7175 A pharmaceutical preservative.
SGTC_206 4546-0025 72.014 µM -0.709035907085987 0.238707017151623 no 2584 0.239151097299159 3697 6620745 YIL048W NEO1
SGTC_1250 0485-0349 40.2 µM -0.70927371047768 0.238633705233832 no 2585 0.2390773196786 3692 6842794 YDL195W SEC31
SGTC_2258 7960471 200 µM -0.709346799899596 0.23861117512232 no 2586 0.239054646456231 3642 2974708
SGTC_2762 leflunomide 42.06 µM -0.709592156009146 0.238535551618007 no 2587 0.238978542621135 3679 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2273 7815444 169.05 µM -0.711164922543152 0.238051106250838 no 2588 0.238491021286711 3647 2824616
SGTC_1788 fluconazole 20 µM -0.712196019164849 0.237733799563842 no 2589 0.238171700852445 3688 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_703 3875-0075 71.8 µM -0.712577609961968 0.237616428764392 no 2590 0.238053585371291 3739 2850814
SGTC_1970 st070122 35.8 µM -0.713016819061555 0.237481374931612 no 2591 0.237917674795724 3711 102928
SGTC_2886 9058944 51.95 µM -0.71586657466078 0.236606118776445 no 2592 0.23703686972094 3567 4949929
SGTC_3330 9141424 71.43 µM -0.718374743324017 0.235837246273043 no 2593 0.236263127732861 3728 27261020
SGTC_2860 9025725 38.96 µM -0.718761311785355 0.235718867355384 no 2594 0.236143999506844 3701 40546248
SGTC_736 0958-0254 92.6 µM -0.718965295494949 0.235656414603536 no 2595 0.236081151490233 3753 6812352
SGTC_2171 5739187 198.077 µM -0.720193520261417 0.235280567668083 no 2596 0.235702926473487 3652 2262761
SGTC_2518 prenyletin 46.28 µM -0.721594858698571 0.234852151021402 no 2597 0.235271800514033 3651 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2172 5754775 163.918 µM -0.72166063980108 0.234832051048445 no 2598 0.235251573465123 3675 2263357
SGTC_232 clozapine 119 µM -0.722380144712757 0.234612262319507 no 2599 0.235030395403486 3673 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2351 9026858 72.31 µM -0.722841203812829 0.23447148142516 no 2600 0.234888724809265 3655 1409300
SGTC_3012 9080433 71.4286 µM -0.723342162489844 0.234318570491651 no 2601 0.234734847700724 3706 17688859
SGTC_2245 6637752 200 µM -0.72334766415919 0.234316891487151 no 2602 0.234733158088417 3723 681890
SGTC_3064 1327-0027 10 µM -0.724323515192844 0.234019185733725 no 2603 0.234433571821426 3603 16000455 YPR107C YTH1
SGTC_222 nsc-310342 10.666 µM -0.728927539605219 0.23261745222097 no 2604 0.233022993870549 3671 432556
SGTC_2424 5537928 59.2 µM -0.729325612802387 0.232496475142436 no 2605 0.232901254240708 3797 5382802
SGTC_199 4063-0024 41.6 µM -0.730429167755527 0.232161280497899 no 2606 0.232563947419757 3738 306215
SGTC_1649 st011737 51.3 µM -0.734947295994895 0.230791749273225 no 2607 0.231185796273213 3740 1761035
SGTC_1921 5740136 50 µM -0.735194055146636 0.230717082019617 no 2608 0.23111065952346 3694 1774243
SGTC_1994 st072947 40.9 µM -0.735432092556132 0.23064506668154 no 2609 0.231038191409947 3774 5286565 YDL195W SEC31
SGTC_1553 gossypol 38.6 µM -0.736245114004559 0.230399191609769 no 2610 0.230790770810516 3630 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3216 9129716 49.47 µM -0.737537052979394 0.230008783252552 no 2611 0.230397909499788 3714 8056934
SGTC_3 0833-0587 95.581 µM -0.738161748748385 0.229820140602154 no 2612 0.230208082078228 3682 5382644
SGTC_1306 1185-0270 9.02 µM -0.738719371535244 0.229651825530037 no 2613 0.230038710167022 3741 1548076
SGTC_1743 st037606 46.3785 µM -0.739136213397032 0.229526049443959 no 2614 0.229912144504627 3752 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_616 4092-0450 108 µM -0.73924865667417 0.229492127900277 no 2615 0.229878010037847 3777 787165
SGTC_563 tetrahydrosecaminediol 614 µM -0.739560970591409 0.229397924732789 no 2616 0.229783215617283 3780 334274 A psychoactive constituent of the cannabis plant.
SGTC_1048 3161-0300 24.5 µM -0.739620858895161 0.229379863115819 no 2617 0.229765040648073 3736 2165101
SGTC_904 1141-0088 396 µM -0.740217328552131 0.229200018304414 no 2618 0.229584067313203 3714 1378119
SGTC_3118 9124250 49.47 µM -0.740588330998086 0.229088195238437 no 2619 0.229471542704192 3698 1504786
SGTC_1060 3448-7350 82 µM -0.741322038839935 0.228867140034548 no 2620 0.229249100996941 3685 570178
SGTC_3185 9108267 49.47 µM -0.741865216432956 0.228703565897518 no 2621 0.229084501170729 3699 4910486
SGTC_2324 6149169 200 µM -0.743127557797975 0.228323674273377 no 2622 0.228702228368248 3681 2888231
SGTC_1737 st035557 69.7 µM -0.743264332364086 0.228282534358014 no 2623 0.228660830663944 3659 5716916
SGTC_2821 7996764 71.43 µM -0.743844415416408 0.228108099640424 no 2624 0.228485303081758 3772 2987135
SGTC_3348 9149464 3.537 µM -0.744954158079887 0.227774601803516 no 2625 0.228149716588382 3730 1951442
SGTC_1461 k072-0203 53.8 µM -0.746553364669213 0.227294494168792 no 2626 0.22766660387534 3688 5418714
SGTC_140 0062-0056 502.533 µM -0.74657820018 0.227287042646889 no 2627 0.22765910572965 3730 3758964
SGTC_2103 5378138 10 µM -0.749047220579854 0.226546937591291 no 2628 0.226914372419276 3789 244142
SGTC_1498 4478-3555 97.6 µM -0.749065372538078 0.226541501465552 no 2629 0.226908902317376 3724 3437919
SGTC_2019 4016004 108 µM -0.750570530134439 0.22609099504971 no 2630 0.226455581159403 3765 45595336
SGTC_7 0192-1582 4.227 µM -0.751087475253081 0.22593638589194 no 2631 0.226300006447027 3793 252616
SGTC_1898 st060199 18.6 µM -0.751094187535866 0.225934378759888 no 2632 0.22629798678164 3762 688866
SGTC_2421 5690543 90.72 µM -0.752617449460289 0.22547914806974 no 2633 0.225839914424692 3792 3397993
SGTC_1853 st056710 91.2 µM -0.753003062580535 0.22536398901913 no 2634 0.225724036830554 3850 269167
SGTC_2921 7974240 10.71 µM -0.753937564172935 0.225085048745671 no 2635 0.225443356607409 3803 2979074 YDR527W RBA50
SGTC_1232 0279-0259 161 µM -0.754071603120463 0.225045055380043 no 2636 0.225403113834958 3784 1560000
SGTC_39 0986-0283 58.349 µM -0.754151925223532 0.225021091504984 no 2637 0.225379000523528 3804 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_916 4466-0038 42 nM -0.7561665204105 0.224420515840722 no 2638 0.224774681512384 3840 5722064 YGL116W CDC20
SGTC_3261 9137475 49.47 µM -0.75740438787541 0.224051943967142 no 2639 0.224403814063022 3661 17027690
SGTC_1239 0337-0584 35.4 µM -0.759144226973148 0.223534493076598 no 2640 0.223883142541545 3821 914301 YML130C ERO1
SGTC_2050 5263056 171 µM -0.75915555727207 0.223531125526836 no 2641 0.22387975404053 3802 763468 YGL055W OLE1
SGTC_2611 pyromycin 23.93 µM -0.759534849258488 0.223418410410921 no 2642 0.22376633772957 3778 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3203 9113543 49.47 µM -0.760261196207922 0.223202650416091 no 2643 0.223549235847175 3857 17018012
SGTC_632 0781-2353 4.65 µM -0.761333890541711 0.222884225621614 no 2644 0.223228831485925 3831 6811515 YHR007C ERG11
SGTC_542 3381-0244 89.3 µM -0.762653504829528 0.222492858927558 no 2645 0.222835033124449 3777 1112843
SGTC_1086 cerivastatin 2.18 µM -0.762696773067028 0.22248003322038 no 2646 0.222822127753159 3725 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_727 3032-0951 202 µM -0.763031509787521 0.222380823757201 no 2647 0.222722302126594 3773 3652836
SGTC_114 0364-0001 490.298 µM -0.763533057911683 0.2222322218757 no 2648 0.22257277750036 3831 4003655
SGTC_1697 st025554 27.742 µM -0.763588849246631 0.222215695165486 no 2649 0.222556148180874 3738 1269519
SGTC_15 0266-0086 27.098 µM -0.763785765179385 0.222157369625024 no 2650 0.222497460536624 3848 1712902 YIL048W NEO1
SGTC_2479 5617353 43.85 µM -0.76708191414252 0.221182364371851 no 2651 0.221516407145767 3803 2731746
SGTC_1802 st050112 57.9 µM -0.769436593489362 0.220487348717529 no 2652 0.220817086001687 3787 4662563
SGTC_97 0535-0701 19.132 µM -0.770015032829591 0.220316806157632 no 2653 0.220645487710045 3714 2832013 YGL099W LSG1
SGTC_2266 7929956 200 µM -0.770457552716134 0.220186388106601 no 2654 0.220514262514813 3762 2967153
SGTC_491 tetrandrine 80.3 µM -0.770528541136926 0.220165470747055 no 2655 0.220493215715955 3758 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1064 honokiol 6.76 µM -0.771960867682138 0.219743666736025 no 2656 0.220068802481144 3797 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_801 0866-0028 10.1 µM -0.772352593117761 0.219628388857244 no 2657 0.219952811825726 3800 6849771
SGTC_3292 9120825 59.784 µM -0.772602922166561 0.219554739629704 no 2658 0.219878707287848 3782 24824900
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.772806243634555 0.219494930928295 no 2659 0.219818528881312 3814 229346 A bile salt which induces apoptosis.
SGTC_2687 chenodiol 100 µM -0.773105531355197 0.219406909985448 no 2660 0.219729963907467 3821 5702181 A cholesterol synthesis inhibitor.
SGTC_1364 1653-0028 37.6 µM -0.773241600324733 0.219366898616017 no 2661 0.219689705266181 3796 5718652
SGTC_2318 6029776 164 µM -0.7733426559086 0.219337185720461 no 2662 0.219659808754432 3773 818325
SGTC_1259 0671-0132 43 µM -0.775110059953777 0.218817898338083 no 2663 0.219137313816379 3752 X1259
SGTC_919 tnp00227 403.569 nM -0.77570450556327 0.218643401225982 no 2664 0.218961739491595 3796 1269246 A methoxyflavone. YNL221C POP1
SGTC_1590 st077108 57.8 µM -0.777747005273868 0.218044444481171 no 2665 0.218359087661776 3747 5489485
SGTC_589 1227-0070 34.1 µM -0.779244881799196 0.21760579863288 no 2666 0.217917738109402 3834 2841384
SGTC_1668 st014914 51.6 µM -0.779578406628445 0.217508196875052 no 2667 0.217819535034991 3807 2839556
SGTC_2485 5633444 17.78 µM -0.783515906926506 0.216357849570228 no 2668 0.216662108176122 3837 5724239
SGTC_2517 totarol 10 µM -0.783962249993687 0.21622767228383 no 2669 0.216531130636229 3808 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_988 1497-1057 103 µM -0.787932394146924 0.215071765234604 no 2670 0.215368125809379 3770 3533044
SGTC_1311 1190-0148 100 µM -0.788876238234545 0.214797493907635 no 2671 0.215092172478351 3878 1961333
SGTC_502 l-744,832 89.3 µM -0.78926574486823 0.214684366570185 no 2672 0.214978351614132 3780 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_746 1095-0025 46.6 µM -0.790691357486943 0.214270610582658 no 2673 0.214562060300854 3837 6749286
SGTC_975 1335-0046 28.5 µM -0.790983118399073 0.214185989941362 no 2674 0.214476921372811 3822 16486740
SGTC_2083 5306046 65.942 µM -0.792016758032771 0.213886355612045 no 2675 0.214175452475306 3850 539837
SGTC_445 e6 berbamine 66 µM -0.79217351299884 0.213840936369367 no 2676 0.214129755231978 3900 6610268 A calcium/calmodulin antagonist.
SGTC_1719 st032227 49.2 µM -0.792419654539638 0.213769628991219 no 2677 0.214058011444365 3837 3125804
SGTC_1255 0566-0045 221 µM -0.792658010205346 0.213700590386833 no 2678 0.213988550369804 3888 2788469
SGTC_3318 9139014 38.6185 µM -0.793264967885018 0.213524846588458 no 2679 0.213811731377371 3791 16643984
SGTC_1185 1319-0113 81.3 µM -0.797634856346014 0.212262039475917 no 2680 0.2125412086931 3877 4672763
SGTC_955 1216-0110 33 µM -0.798883686706588 0.211901957005928 no 2681 0.212178929490792 3795 3619719
SGTC_2299 7976368 114.88 µM -0.801317263652882 0.211201297254285 no 2682 0.211473999537262 3891 2979718
SGTC_1637 st007924 17.4 µM -0.801457318981265 0.211161014782854 no 2683 0.211433471734828 3801 683336
SGTC_2696 st077691 74.316 µM -0.80235216614641 0.210903746689928 no 2684 0.211174637254503 3845 757133
SGTC_443 clozapine 122 µM -0.803906313860427 0.210457367089255 no 2685 0.21072554168109 3724 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_945 3381-0768 11.3 µM -0.803920995152168 0.210453152999976 no 2686 0.210721301962497 3876 1126236 YIL048W NEO1
SGTC_495 decylubiquinone 155 µM -0.8039862821705 0.210434413741747 no 2687 0.210702448738073 3861 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2981 9013952 38.96 µM -0.806238215695532 0.209788643607888 no 2688 0.210052753754702 3794 2996344
SGTC_3086 9117350 49.47 µM -0.806283340140533 0.20977571552605 no 2689 0.21003974714895 3751 2679265
SGTC_2200 6600604 21.907 µM -0.807726345374032 0.209362543849364 no 2690 0.209624066949205 3804 2904777
SGTC_2697 mebhydrolin 72.4 µM -0.8099877527684 0.208716005569822 no 2691 0.208973607362495 3882 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2876 9059903 25.97 µM -0.810491266675993 0.208572210853821 no 2692 0.208828941199298 3781 6916095
SGTC_2914 7968218 45.32 µM -0.810744188208169 0.208500002955888 no 2693 0.208756295789401 3839 2977111
SGTC_430 0958-0115 16.4 µM -0.811630221740606 0.208247160882567 no 2694 0.208501922225207 3822 6833180
SGTC_2285 7945142 200 µM -0.812335826850785 0.208045936044936 no 2695 0.208299479098599 3896 2970608
SGTC_2674 ligustilide 100 µM -0.813897581569606 0.207600962376326 no 2696 0.20785181313699 3895 5319022 A signalling regulator.
SGTC_2840 9008771 71.43 µM -0.813996178892555 0.207572889006145 no 2697 0.207823569990802 3815 2992978
SGTC_1300 1094-0077 113 µM -0.814506635369679 0.207427583880615 no 2698 0.207677386274032 3799 5532636
SGTC_946 3434-1334 87.4 µM -0.814594389259442 0.207402610159923 no 2699 0.207652261575005 3845 4047976
SGTC_533 1222-0222 6.71 µM -0.814609243098805 0.207398383108564 no 2700 0.20764800896981 3935 3982874
SGTC_2926 9010726 65.15 µM -0.814819953984823 0.207338425259973 no 2701 0.207587688680915 3882 2994293
SGTC_2966 9084041 48.03 µM -0.816130892297811 0.206965627640136 no 2702 0.207212638516354 3802 17741380
SGTC_2847 9005661 71.43 µM -0.817134372386963 0.206680531552782 no 2703 0.206925820951431 3830 2991449
SGTC_1751 st044839 27.194 µM -0.817594558093325 0.206549867217098 no 2704 0.206794367968051 3808 5291326
SGTC_884 0851-0618 334 µM -0.818932900544309 0.206170138753907 no 2705 0.206412348784084 3897 9642473
SGTC_625 k213-0058 121 µM -0.8192957809693 0.206067249906156 no 2706 0.206308839564625 3913 3655420
SGTC_1607 st000305 50.6 µM -0.819819806906758 0.205918724611082 no 2707 0.206159418963396 3853 5457690
SGTC_2532 xanthone 78.9 µM -0.820793826549382 0.2056428258365 no 2708 0.20588185780834 3830 7020 An insecticide.
SGTC_228 caffeine 993.056 µM -0.824227105356629 0.20467207376997 no 2709 0.204905264227479 3847 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3343 9148379 18.9835 µM -0.824525520287312 0.204587826568926 no 2710 0.204820510628099 3926 1955036
SGTC_1785 bathophenanthroline 24 µM -0.82471865412084 0.204533312867944 no 2711 0.204765669300691 3808 72812 An iron chelator.
SGTC_2121 5257820 149.641 µM -0.826723540822264 0.203967926971955 no 2712 0.204196887672784 3942 791256
SGTC_352 k048-0007 5.11 µM -0.82732658329038 0.203798048987412 no 2713 0.204025990190541 3886 6811911
SGTC_1506 4226-2149 212 µM -0.827361531334624 0.203788206656073 no 2714 0.204016088803222 3904 991114
SGTC_1519 esterone 74 µM -0.829195644608877 0.203272067603298 no 2715 0.203496854554539 3857 698 A steroid.
SGTC_2993 9054257 71.4286 µM -0.829214109266382 0.203266875421357 no 2716 0.203491631253408 3830 6470217 YGL055W OLE1
SGTC_764 1951-2361 146 µM -0.82935171519768 0.203228183720756 no 2717 0.203452707666184 3850 5438930
SGTC_2070 5230947 200 µM -0.830328629575479 0.20295362371956 no 2718 0.203176502731022 3928 2835538
SGTC_716 1683-5115 658 µM -0.830803480886613 0.202820247675125 no 2719 0.20304232796105 3858 723597
SGTC_151 3013-0144 2.285 µM -0.832638945224126 0.202305195794216 no 2720 0.2025241938508 3836 906558 YHR107C CDC12
SGTC_1052 3253-3998 198 µM -0.832814802691456 0.202255889317328 no 2721 0.202474592490175 3832 5450317
SGTC_2220 6782180 200 µM -0.833781015395815 0.201985113287896 no 2722 0.202202197617009 3776 833803
SGTC_912 3474-0017 2.18 µM -0.83418763403915 0.201871225452585 no 2723 0.202087629186632 3916 3360550
SGTC_1575 cyproterone acetate 48 µM -0.836298001197727 0.201280760824051 no 2724 0.201493638673172 3907 9880 An androgen receptor antagonist and liver toxin.
SGTC_1298 1079-1278 263 µM -0.837061917776531 0.201067278285254 no 2725 0.20127888248517 3903 2840950
SGTC_3069 9117009 49.47 µM -0.837208044001757 0.201026457633282 no 2726 0.201237818363715 3833 41904981
SGTC_2472 5377652 49.4 µM -0.8393570620698 0.200426699488017 no 2727 0.200634485598182 3970 1610903
SGTC_2515 chrysin 20.77 µM -0.840465563982507 0.200117754159612 no 2728 0.200323700801869 3914 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3114 9122766 49.47 µM -0.841386046532721 0.199861428484432 no 2729 0.200065849931721 3895 17176985
SGTC_1251 0490-5699 265 µM -0.841962219533967 0.199701082808689 no 2730 0.199904550614098 3916 3883818
SGTC_2823 7987624 58.44 µM -0.842318266875944 0.199602035557345 no 2731 0.199804914461588 3881 2239440
SGTC_1968 st069590 43.6 µM -0.844475476546397 0.19900256325347 no 2732 0.199201880741601 3903 6384066
SGTC_3060 1327-0027 12.5 µM -0.845960905863648 0.198590405087268 no 2733 0.19878727682065 3827 16000455 YPR107C YTH1
SGTC_2678 equilin 100 µM -0.846214259538058 0.198520159140787 no 2734 0.198716614265509 3899 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3186 9110464 49.47 µM -0.847362857988223 0.198201881776553 no 2735 0.198396450139297 3898 17018021
SGTC_2862 9027634 71.43 µM -0.84762891689508 0.198128200648062 no 2736 0.19832233242486 3831 5012562
SGTC_112 phenothiazine 287.218 µM -0.847934446582457 0.198043609066305 no 2737 0.198237239701414 3822 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3021 9087658 49.47 µM -0.848641048949951 0.197848056612406 no 2738 0.198040529124664 3844 25237042
SGTC_2944 9067346 25.62 µM -0.849271198133617 0.197673761047788 no 2739 0.197865201773764 3832 6473075
SGTC_1760 st045453 10.4495 µM -0.850070030546549 0.19745294212952 no 2740 0.197643076268597 3964 3323419 YIL048W NEO1
SGTC_1546 5-methoxyflavanone 78.7 µM -0.850954042652165 0.197208751179129 no 2741 0.197397441229786 3890 147795
SGTC_1654 st012436 41.8 µM -0.854090764221966 0.196343768957565 no 2742 0.1965273504263 3848 4323132
SGTC_3101 9120531 49.47 µM -0.854354010567458 0.196271280906926 no 2743 0.196454434740026 3909 24824904
SGTC_2331 7980721 200 µM -0.855442013559576 0.195971858328465 no 2744 0.196153246537919 3886 2981221
SGTC_3170 9103054 49.47 µM -0.856031749450452 0.19580967663616 no 2745 0.195990109030034 3936 16432970
SGTC_2738 aclarubicin 5.55 µM -0.856578594100047 0.195659363157627 no 2746 0.195838910015279 3851 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1594 piperine 70.1 µM -0.859380171983541 0.194890381057427 no 2747 0.19506540269261 3898 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2832 7992762 51.95 µM -0.859626865682068 0.1948227562883 no 2748 0.194997380378717 3879 2985177
SGTC_3096 9117468 49.47 µM -0.860405131955985 0.194609508042337 no 2749 0.19478287894526 3850 41316311
SGTC_2032 5185112 25.99 µM -0.860779073928308 0.194507096899922 no 2750 0.194679866200859 3812 5718189
SGTC_341 1486-1430 230 µM -0.861466788002604 0.194318838935961 no 2751 0.194490502734168 3901 2054753 YPL210C SRP72
SGTC_595 3909-8003 73.7 µM -0.863013773480609 0.193895765798729 no 2752 0.194064947072717 4001 699517
SGTC_3125 9127534 49.47 µM -0.863070990795589 0.193880128649575 no 2753 0.194049218217268 3790 1639235
SGTC_1909 st060837 51.5 µM -0.863132168339576 0.193863410043856 no 2754 0.194032401566844 3938 678937
SGTC_2953 9074162 66.49 µM -0.864389054455407 0.193520122576031 no 2755 0.193687101824681 3890 16451992
SGTC_2700 st077718 96.8 µM -0.864797177892813 0.193408733511936 no 2756 0.193575060193625 3913 904970
SGTC_2545 solidagenone 89.61 µM -0.86656186116947 0.192927549189685 no 2757 0.193091058974473 3727 6708572 An anti ulcer agent
SGTC_417 st075190 100 µM -0.867747182437983 0.192604753050556 no 2758 0.192766375072597 3917 222757
SGTC_3100 9120536 49.47 µM -0.868931647895659 0.192282519925135 no 2759 0.192442259018382 3760 16421196
SGTC_1933 st074711 15.9 µM -0.873930627442289 0.190926186541743 no 2760 0.191078017099818 3913 17250958
SGTC_2912 7964298 10.93 µM -0.87437918389415 0.190804770890352 no 2761 0.190955894848013 3979 2975850
SGTC_1732 st034308 51.822 µM -0.874708237808559 0.19071573242239 no 2762 0.19086633834671 3808 830119
SGTC_85 0868-0259 160.055 µM -0.876974131259101 0.190103298514189 no 2763 0.190250344517328 3880 83173
SGTC_2298 7976326 193.81 µM -0.878375253584681 0.189725203513296 no 2764 0.189870054611958 3807 2235818
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.879826294967634 0.189334125666633 no 2765 0.189476708807721 3942 7104
SGTC_2263 7948595 193.29 µM -0.880795230206653 0.189073259311425 no 2766 0.189214330938019 3923 2971371
SGTC_2140 5586273 200 µM -0.880843695193045 0.189060216903018 no 2767 0.189201212986843 3905 854421
SGTC_2336 9001819 198.65 µM -0.881353007942104 0.188923189303975 no 2768 0.189063391871603 3972 2989602
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.88143768912712 0.188900412263279 no 2769 0.189040482959108 4023 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1689 st020265 53.493 µM -0.882747816313613 0.188548237669913 no 2770 0.188686270415324 3931 5758320 YPR016C TIF6
SGTC_2947 9072639 7.68 µM -0.884780819001018 0.188002549456501 no 2771 0.188137428263883 3985 16488146
SGTC_3009 9080819 71.4286 µM -0.887889417200964 0.187170042766682 no 2772 0.187300118932577 3969 17027216
SGTC_287 k060-0039 29.6 µM -0.890875613754159 0.186372466770341 no 2773 0.186497952137167 4010 5861974
SGTC_1816 st051957 91.6 µM -0.890881204738139 0.186370975465434 no 2774 0.186496452257934 3935 674121
SGTC_310 1273-0058 1.06 µM -0.89248977840537 0.185942221416904 no 2775 0.186065234551846 3868 2734232
SGTC_81 0411-0046 9.971 µM -0.893433917993405 0.185690852696659 no 2776 0.185812422824252 3885 12925265
SGTC_3127 9126946 49.47 µM -0.89503653171163 0.18526465404792 no 2777 0.185383779879415 3967 27243249
SGTC_908 3448-7491 47.7 µM -0.898065482824686 0.184460796194568 no 2778 0.184575319875142 3980 1203031
SGTC_691 1548-0686 185 µM -0.898123211828858 0.184445496507442 no 2779 0.184559932698798 3984 46495133
SGTC_1167 k781-0610 148 µM -0.900631072353404 0.1837816104239 no 2780 0.183892253990094 3984 4525169
SGTC_624 k048-0052 28 µM -0.900699017448428 0.183763644591447 no 2781 0.183874185624388 3948 6835531
SGTC_937 3122-0005 46.7 µM -0.900883635953951 0.183714833861103 no 2782 0.183825096352143 4027 759535
SGTC_2002 4023503 131 µM -0.901051474739725 0.183670466480529 no 2783 0.183780475820275 3956 4736863 YCR052W RSC6
SGTC_2572 astragaloside iv 100 µM -0.901695368486526 0.183500318189793 no 2784 0.18360935700113 4054 45006101 An anti-inflammatory agent.
SGTC_3201 9113999 49.47 µM -0.903077200394579 0.183135502254882 no 2785 0.183242461776327 4009 16649224
SGTC_425 3825-7017 13.1 µM -0.903491463250938 0.183026221377551 no 2786 0.183132558478936 4071 3397440
SGTC_3250 9135583 49.47 µM -0.906115768778617 0.182334885732974 no 2787 0.182437289909249 3999 7699353
SGTC_465 cgp-37157 41 µM -0.906682466123056 0.182185811939099 no 2788 0.182287369108222 3923 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1014 4130-3005 69.3 µM -0.907551456869582 0.181957365722401 no 2789 0.182057625636278 3996 743608
SGTC_1667 st014849 34.6 µM -0.908233257095976 0.181778254890422 no 2790 0.181877498324377 4018 5348460
SGTC_1711 st032263 62.8 µM -0.909228103551187 0.181517103895091 no 2791 0.18161486623744 3968 3958979
SGTC_478 N-arachidonylglycine 10 µM -0.90971758687746 0.181388698891253 no 2792 0.181485733424087 3919 5283389
SGTC_2084 5306078 60.6385 µM -0.910101099292594 0.181288132730782 no 2793 0.181384597443586 3926 679340
SGTC_3213 9129884 49.47 µM -0.910276748334198 0.181242084996107 no 2794 0.181338288854631 3985 17190742
SGTC_2434 5670830 169.91 µM -0.910339475397557 0.181225642393694 no 2795 0.181321753115862 4029 1549830
SGTC_2704 st078022 71.1 µM -0.910405938875261 0.181208221386958 no 2796 0.181304233435815 4031 54697681
SGTC_439 amiodarone 34.4 µM -0.911695984463267 0.180870290184074 no 2797 0.180964389206383 3853 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2866 9034245 58.44 µM -0.911783162754028 0.180847467833753 no 2798 0.180941437729596 3955 6462273
SGTC_575 k072-0246 11.9 µM -0.913890467186943 0.180296347172003 no 2799 0.18038720161235 4025 6796779
SGTC_611 3453-1652 23.7 µM -0.915915649133876 0.179767698151543 no 2800 0.179855569111972 3987 1560575
SGTC_2658 polymyxin b sulfate 77.05 µM -0.917101787906675 0.179458523771467 no 2801 0.179544652134314 4010 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2055 5235184 200 µM -0.918829525247417 0.179008776839652 no 2802 0.17909237328638 4063 2836034
SGTC_1291 0993-0025 5.79 µM -0.921073678190357 0.17842566175485 no 2803 0.178505980774701 3992 4353356
SGTC_1394 3474-0001 65.7 µM -0.921092408355927 0.178420799996387 no 2804 0.178501091715773 3975 5017666 YIL048W NEO1
SGTC_998 3996-0085 177 µM -0.921180114054185 0.17839803548203 no 2805 0.178478199376327 4022 715391
SGTC_1138 3761-0006 1.03 µM -0.921726876781282 0.178256161362 no 2806 0.178335528825806 3972 12061087
SGTC_2088 5278280 127.392 µM -0.922049573837406 0.178172461231117 no 2807 0.178251359000096 4065 791502
SGTC_61 0978-8327 98.565 µM -0.923139130060764 0.177890038685592 no 2808 0.177967352522 3933 6150059 YHR072W ERG7
SGTC_389 tpck 16.7 µM -0.924803951550596 0.177459047966998 no 2809 0.177533947390495 4020 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_816 0325-0417 81.3 µM -0.925020427960059 0.177403054796346 no 2810 0.177477640790043 4036 68101
SGTC_2919 7978188 46.38 µM -0.9253550201053 0.177316532092211 no 2811 0.177390633873414 3995 2980291
SGTC_96 0929-0093 37.281 µM -0.925608281282975 0.177251058610627 no 2812 0.17732479406789 3984 6991579
SGTC_2195 6536160 144.242 µM -0.929033199735321 0.176367143012303 no 2813 0.176435940540079 3939 3834386
SGTC_442 cape 100 µM -0.929357091468446 0.176283696421084 no 2814 0.176352028512458 3954 5281787
SGTC_2372 9071633 200 µM -0.931040152389275 0.175850479475986 no 2815 0.175916397273151 4047 21321366
SGTC_259 usnic acid 108.925 µM -0.933209341669743 0.175293129430095 no 2816 0.175355946202768 4092 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1564 D-Arginine 115 µM -0.933842988852809 0.175130532168169 no 2817 0.175192445347719 4029 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2857 9024691 58.44 µM -0.934426796860707 0.17498080861013 no 2818 0.175041890170786 4104 16478292
SGTC_1036 k216-0215 33.5 µM -0.937681820568639 0.174147513799764 no 2819 0.174203974540245 4002 622330
SGTC_1217 1183-1422 255 µM -0.938841002821288 0.173851370085371 no 2820 0.173906191757829 4040 2849664
SGTC_2215 7188065 200 µM -0.939125532266963 0.173778728510134 no 2821 0.173833148384057 4035 940217
SGTC_1230 0170-0365 3.77 µM -0.939322778756244 0.173728381976927 no 2822 0.173782523429858 4074 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_143 4032-1194 15.74 µM -0.939463380232615 0.173692499566483 no 2823 0.173746442615436 4028 1806963
SGTC_3342 9147791 14.508 µM -0.939868772362951 0.17358906725833 no 2824 0.17364243853636 3917 1838168
SGTC_692 k241-0027 77.8 µM -0.940031710090017 0.173547506145931 no 2825 0.173600647732 4076 3600480
SGTC_3068 9116768 49.47 µM -0.940880396633987 0.173331131017533 no 2826 0.173383077309191 4004 41904888
SGTC_2467 5474540 200 µM -0.942232602843095 0.172986737069938 no 2827 0.173036782693371 3976 5413519
SGTC_1117 retinoic acid 1.10837 µM -0.942533477266212 0.172910166575753 no 2828 0.172959789921316 4065 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_202 3594-0513 34.79 µM -0.943948024313058 0.17255046348768 no 2829 0.172598104601603 4022 708429
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.944404127828497 0.172434583401611 no 2830 0.172481586454985 4018 5106787 A p450 inhibitor.
SGTC_2129 girgensonine 121.053 µM -0.94541912746125 0.172176885380333 no 2831 0.172222470413023 4043 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3351 9150312 21.596 µM -0.945693085841504 0.172107372292906 no 2832 0.17215257503747 3941 4904905
SGTC_1602 st001878 87.6 µM -0.946486969835983 0.171906036569689 no 2833 0.171950132588901 4042 595405 YLR310C CDC25
SGTC_662 k832-1615 104 µM -0.947195816035954 0.171726394295163 no 2834 0.171769503493763 4058 5878478
SGTC_2888 9058547 12.99 µM -0.947477511345936 0.171655037805336 no 2835 0.17169775519706 3936 16476514
SGTC_2848 9016370 25.97 µM -0.949510328167878 0.171140664844378 no 2836 0.171180560807647 4005 7894410
SGTC_2798 7813637 45.45 µM -0.949811943829429 0.171064429713647 no 2837 0.171103907949507 4050 956368
SGTC_3232 9132874 49.47 µM -0.954947776366786 0.169769652777716 no 2838 0.169802053658499 3989 3784940
SGTC_881 0833-0569 170 µM -0.955096918491013 0.169732147219523 no 2839 0.169764343582378 4039 5418700
SGTC_53 0973-0023 39.979 µM -0.955528068730613 0.169623753479073 no 2840 0.169655358926668 3911 674768
SGTC_1496 4469-0713 57.4 µM -0.956591211119003 0.169356662939316 no 2841 0.169386813318018 4014 746691
SGTC_3212 9128307 49.47 µM -0.958896056143851 0.168778550132479 no 2842 0.168805555891611 4004 27243542
SGTC_325 2810-4341 181 µM -0.959110497792987 0.168724827356795 no 2843 0.168751541231493 4044 774970
SGTC_3010 9080089 71.4286 µM -0.960822102020187 0.168296423428176 no 2844 0.168320811783116 4063 17027233
SGTC_2521 angolensin 13.4 µM -0.96362267902509 0.167596966753547 no 2845 0.16761756615809 4109 821428 A flavenoid.
SGTC_2162 5663267 200 µM -0.963835987153651 0.167543768940888 no 2846 0.167564080578015 4026 6456493
SGTC_2107 5363541 170.161 µM -0.964401900446132 0.167402686158992 no 2847 0.167422234903144 4026 244052
SGTC_2775 cyproheptadine 69.59 µM -0.965681238582009 0.167084028043372 no 2848 0.167101855160336 4053 2913 A selective serotonin reuptake inhibitor.
SGTC_127 0180-0333 59.125 µM -0.966396338120862 0.166906081252373 no 2849 0.166922947869522 3917 771601
SGTC_1109 tnp00067 928.257 nM -0.967868492418931 0.166540132467937 no 2850 0.166555025846234 4042 676295
SGTC_3215 9129942 49.47 µM -0.968889116775232 0.166286729436448 no 2851 0.16630025804612 4041 17682944
SGTC_280 3448-3607 3.04 µM -0.970582670777349 0.165866799551476 no 2852 0.165878069431839 4029 626179
SGTC_3105 9121040 49.47 µM -0.970680776343437 0.165842494535338 no 2853 0.165853633794845 3898 41448907
SGTC_2776 terbinafine 19.92 µM -0.972003951775172 0.165514911354973 no 2854 0.165524291300559 4087 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2646 retinol 96.75 µM -0.973131548145455 0.165236078911061 no 2855 0.165243963120055 4073 445354 A vitamin A analog and teratogen.
SGTC_3338 9144300 39.5675 µM -0.97368500150099 0.165099332052489 no 2856 0.165106483304807 4073 4901274
SGTC_1508 1080-0625 72.9 µM -0.973789317478213 0.165073565943499 no 2857 0.165080579134423 3931 767111
SGTC_3151 9099821 49.47 µM -0.976203230260554 0.164478055228952 no 2858 0.164481881396956 4042 17174189
SGTC_1010 4112-3296 15.2 µM -0.978252454440297 0.163973607149931 no 2859 0.163974739478449 4142 704384
SGTC_1474 0330-0125 5.35 µM -0.978898161471761 0.163814864624525 no 2860 0.16381515035424 4069 X1474
SGTC_1683 st010134 710 nM -0.979189830717956 0.16374319250802 no 2861 0.163743096174297 4059 3818134
SGTC_875 0709-0210 25.7 µM -0.979237492221008 0.163731482544013 no 2862 0.163731323798209 4080 6251364
SGTC_756 0508-1999 28.3 µM -0.984611347472343 0.162414665286745 no 2863 0.162407506818147 4074 6753853
SGTC_1512 0259-0544 12.2 µM -0.984976134488223 0.162325527865259 no 2864 0.162317896920775 4039 18476
SGTC_65 0798-0905 34.986 µM -0.987363188821056 0.161743026081308 no 2865 0.16173231180367 4190 3602145
SGTC_538 2922-0838 53.3 µM -0.987812084111126 0.161633636611826 no 2866 0.161622344129622 4065 777039
SGTC_1358 1509-0022 2.48 µM -0.991043562420469 0.160847594274519 no 2867 0.160832154668162 4099 3258434
SGTC_1397 3532-0190 20.1 µM -0.991097599931754 0.160834471147269 no 2868 0.160818962418937 4026 5322280
SGTC_1433 4060-0023 7.6 µM -0.994331490052602 0.160050386618542 no 2869 0.160030754871799 4095 3840627
SGTC_2131 toluylene red 5.2905 µM -0.994610007210963 0.159982974832006 no 2870 0.159962989244174 4074 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_902 1120-0002 2.07 µM -0.99505463661156 0.159875396028572 no 2871 0.15985484597441 4058 3280475
SGTC_466 geldanamycin 89.2 µM -0.996118696510487 0.159618137176598 no 2872 0.159596238330333 4005 5288382 HSP90 inhibitor.
SGTC_383 2324-0395 7.37 µM -0.996622199521234 0.159496499216694 no 2873 0.159473963144814 4086 3146421
SGTC_98 0074-0023 107.663 µM -0.997865752019842 0.159196337663832 no 2874 0.159172230551173 4108 3563821
SGTC_2024 5144227 134 µM -0.998689450465268 0.158997721901412 no 2875 0.158972576349044 4145 3475211
SGTC_467 ro 31-8220 72.8 µM -0.998850164747598 0.158958988320847 no 2876 0.158933640357824 4027 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2476 5806916 10.51 µM -0.999532062916639 0.15879471353856 no 2877 0.15876850749812 3954 2870194
SGTC_300 r073-0011 5.04 µM -1.000392220893 0.158587653306563 no 2878 0.158560366569859 4081 2735780
SGTC_1121 fusaric acid 630.51 nM -1.00245681108166 0.158091380777949 no 2879 0.158061507831338 4054 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2436 5633522 8.09 µM -1.00285226778481 0.157996439966745 no 2880 0.15796607289584 4081 5724242
SGTC_72 0744-0168 198.391 µM -1.00495628752859 0.157491938735845 no 2881 0.157458949414625 3990 677577
SGTC_1772 st048439 82.2 µM -1.00755757880504 0.156869667031848 no 2882 0.15683345136733 4153 2927068 YDL195W SEC31
SGTC_1613 st002381 52.1 µM -1.00848678357098 0.156647778635085 no 2883 0.156610414688174 4081 551167
SGTC_2337 9009472 200 µM -1.01084500989039 0.156085576607392 no 2884 0.156045308353912 4073 5742383
SGTC_1676 st018489 23.4 µM -1.01165491626244 0.155892801748729 no 2885 0.155851539325528 4129 3696235
SGTC_2282 7944268 200 µM -1.01220724893535 0.155761424938241 no 2886 0.155719485482362 4134 2970414
SGTC_3240 9133527 49.47 µM -1.01318548004401 0.155528923929536 no 2887 0.155485787302296 4034 17617455
SGTC_600 1495-0418 41.6 µM -1.01466614067354 0.155177443768099 no 2888 0.155132499745655 4090 5377768
SGTC_974 1326-0144 138 µM -1.02035334426981 0.153832290349114 no 2889 0.153780456255513 4137 5411856
SGTC_1878 temozolomide 1 mM -1.02045470821753 0.153808385676771 no 2890 0.153756429530303 4020 5394 DNA alkylating agent.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.02098402606052 0.153683596529362 no 2891 0.153631003455091 4112 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1305 1181-0477 144 µM -1.02174812495419 0.153503574909511 no 2892 0.153450063658481 4182 6252086
SGTC_2970 9090938 41.86 µM -1.02213779706562 0.153411821994959 no 2893 0.153357843070292 4192 17217104
SGTC_1027 k015-0025 8.67 µM -1.02327336836067 0.153144645514107 no 2894 0.15308930592134 4073 3598955
SGTC_688 0527-0193 473 µM -1.02338849316588 0.153117576251457 no 2895 0.153062098897415 4161 4007154
SGTC_587 k089-0003 57 µM -1.02608812603628 0.152483721445324 no 2896 0.152425023348765 3990 9659696
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.02679089067657 0.152319003298426 no 2897 0.152259469836723 4085 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3144 9087057 49.47 µM -1.02938800625608 0.151711301085113 no 2898 0.151648691417053 3989 17249618
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.0321939990485 0.151056536776955 no 2899 0.150990622848277 4101 641818 YHR062C RPP1
SGTC_2743 auranofin 4.32 µM -1.03532532415095 0.150328081081483 no 2900 0.150258503514303 4101 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_753 1322-0200 289 µM -1.03649133748781 0.150057424728901 no 2901 0.149986489322417 4202 5403907
SGTC_645 0845-0943 5.41 µM -1.03661511311744 0.150028712873962 no 2902 0.149957633532577 4124 1885106
SGTC_1625 st003711 30.1 µM -1.03821514351365 0.149657888431685 no 2903 0.149584951980812 4213 24207034 YER133W GLC7
SGTC_2958 9077254 16.72 µM -1.0386798908969 0.149550292882192 no 2904 0.149476818235806 4208 16457351
SGTC_2789 5281112 71.43 µM -1.03910176013421 0.149452668935307 no 2905 0.14937870622479 4148 765948
SGTC_185 k048-0037 25.491 µM -1.03957791396133 0.149342534205969 no 2906 0.149268021174074 4183 6827589
SGTC_2183 6420625 130.508 µM -1.0401025396973 0.149221250642649 no 2907 0.149146131936507 4120 2897619
SGTC_1606 st000094 49.2 µM -1.04033182598237 0.149168264643708 no 2908 0.149092881449557 4170 1242210
SGTC_284 0988-0104 32.6 µM -1.04037893869037 0.149157378876829 no 2909 0.149081941353475 4123 4666532
SGTC_2365 9042475 200 µM -1.04226279936701 0.148722532586821 no 2910 0.14864492727765 4218 6464479
SGTC_1997 st073024 93.8 µM -1.04249750213168 0.148668416225374 no 2911 0.148590541473861 4137 686268
SGTC_422 cantharidin 155 µM -1.04280781528862 0.14859688628116 no 2912 0.148518655500879 4051 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_891 0929-0073 133 µM -1.04808771602011 0.147383348607456 no 2913 0.147299097673949 4172 5603632
SGTC_1236 0330-0013 258 µM -1.04834349936464 0.147324728248965 no 2914 0.147240187473236 4155 4617066
SGTC_951 1171-0579 82.7 µM -1.0514692047091 0.146609642190703 no 2915 0.146521572952578 4102 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1184 1269-1718 139 µM -1.05505927090073 0.145791200227625 no 2916 0.145699108989904 4200 5403821
SGTC_1257 0669-0121 16 µM -1.05523509270103 0.145751196455408 no 2917 0.14565890908367 4170 4307855
SGTC_3034 9090421 49.47 µM -1.05643540691885 0.145478292668099 no 2918 0.145384668411619 4042 17173761
SGTC_2080 5212524 12.4 µM -1.05660962178261 0.145438711704339 no 2919 0.145344893715196 4037 260183
SGTC_3278 9139605 49.47 µM -1.05795103645374 0.145134189929632 no 2920 0.145038882825289 4171 7958859
SGTC_2296 7971656 126.45 µM -1.06122585807199 0.144392558655582 no 2921 0.144293635337399 4201 666570
SGTC_1020 4335-0961 93.3 µM -1.06239372396996 0.1441286972271 no 2922 0.144028490879581 4097 669075
SGTC_2843 9000894 45.46 µM -1.06260908771596 0.144080074611772 no 2923 0.143979632041314 4083 2242070
SGTC_1623 st003709 20.3 µM -1.06445102464543 0.143664672874553 no 2924 0.143562214770419 4116 16192618
SGTC_2415 st077333 57.7 µM -1.06707909068572 0.143073380396328 no 2925 0.142968061429587 4220 2766255
SGTC_358 0075-0058 9.45 µM -1.06718010950897 0.143050684883443 no 2926 0.142945256298839 3975 1069125
SGTC_1346 1488-2224 62.4 µM -1.0682994624046 0.142799366950392 no 2927 0.14269272546022 4177 3722427
SGTC_3049 9092223 49.47 µM -1.07044289930858 0.142318954299784 no 2928 0.142209999084766 4146 8623917
SGTC_2015 5119600 184 µM -1.07165835944114 0.142047017272507 no 2929 0.141936755200725 4198 2828786
SGTC_1258 0671-0043 57.1 µM -1.07452853265369 0.141406265073805 no 2930 0.141292931838278 4187 4298767
SGTC_653 0203-0016 55.2 µM -1.07475904700691 0.141354888980518 no 2931 0.141241309992014 4221 295302
SGTC_549 1661-1316 519 µM -1.07534402759943 0.141224567704048 no 2932 0.141110365666528 4196 2857282
SGTC_536 3852-0578 10.6 µM -1.07731461343004 0.14078616245732 no 2933 0.140669867958253 4227 2869208
SGTC_410 α-linolenic acid 100 µM -1.07781459351792 0.140675076626128 no 2934 0.14055825278469 4224 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3071 9117417 49.47 µM -1.07839955474769 0.140545185170747 no 2935 0.140427742816478 4127 45595590 YGL055W OLE1
SGTC_161 4065-0411 162.148 µM -1.07902813106141 0.140405699698212 no 2936 0.140287593677404 4173 1906281 YLR208W SEC13
SGTC_3061 glucosamine 200 µM -1.0792809135163 0.140349632016831 no 2937 0.140231259383229 4089 91431 and experimental redox chemotherapeutic
SGTC_1136 pergolide 1.05886 µM -1.08081441218119 0.140009824687316 no 2938 0.139889838110388 4143 47811 A dopamine receptor agonist.
SGTC_2645 abamectin 100 µM -1.0819870991671 0.139750346982814 no 2939 0.139629130205263 4131 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1315 1237-0019 3.69 µM -1.08238764349657 0.139661794426103 no 2940 0.139540158254479 4194 825140
SGTC_1414 3917-0015 5.4 µM -1.08295456393542 0.139536524577364 no 2941 0.139414295497362 4152 6618702
SGTC_628 1636-0253 16 µM -1.08477147822413 0.139135564253875 no 2942 0.139011440430367 4177 4456143
SGTC_2358 9037157 4 µM -1.08572055050198 0.138926433156805 no 2943 0.138801322914104 4180 2388925
SGTC_80 0159-0065 512.242 µM -1.08660495494116 0.138731744566458 no 2944 0.138605717159322 4072 1548079
SGTC_2102 5377816 72.7585 µM -1.08831951428123 0.138354839187282 no 2945 0.138227039320039 4231 1379702
SGTC_1104 tacrolimus 29.8 µM -1.08872578238606 0.138265633118596 no 2946 0.138137414347862 4240 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3019 9081971 49.47 µM -1.0897967401127 0.138030666183625 no 2947 0.137901345137372 4210 16451803
SGTC_1923 st058458 19.1 µM -1.09275879471058 0.137382213528585 no 2948 0.137249858828747 4204 3534982
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.09419530028533 0.137068484112654 no 2949 0.136934666122979 4230 91467 include heat shock
SGTC_224 benfluorex 43.875 µM -1.09442499480737 0.137018364801757 no 2950 0.136884313315403 4224 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3303 9125618 40.5795 µM -1.09509523911144 0.13687218918114 no 2951 0.136737457113078 4198 22695467
SGTC_710 3448-4187 58 µM -1.09821058275916 0.136194153755621 no 2952 0.136056273092577 4168 3946412
SGTC_1293 1000-1278 195 µM -1.09966628300804 0.135878118820797 no 2953 0.135738775263729 4235 678847
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.09980071263392 0.135848959274801 no 2954 0.135709480891652 4171 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1846 st056244 14.8 µM -1.10138782274713 0.13550501824763 no 2955 0.135363951496176 4224 5393182
SGTC_56 0957-0365 83.25 µM -1.10162656851994 0.135453331568232 no 2956 0.135312026427624 4171 6752360
SGTC_1873 rapamycin 2 nM -1.10313828363505 0.135126370145583 no 2957 0.134983558860221 4158 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3238 9133470 49.47 µM -1.10350989977949 0.135046078056268 no 2958 0.134902897399886 4190 3534688
SGTC_449 xestospongin c 11.1929 µM -1.10407668042775 0.134923681371762 no 2959 0.134779938024276 4211 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1954 st077032 68.9 µM -1.10492258839397 0.134741148517384 no 2960 0.13459656686 4161 698907
SGTC_1141 3253-0389 52.6 µM -1.106142695172 0.13447816837465 no 2961 0.134332380721065 4196 5402031
SGTC_2827 7993847 71.43 µM -1.1066883159151 0.134360680124868 no 2962 0.134214354364671 4278 2985692
SGTC_3025 9087895 49.47 µM -1.10780292512019 0.134120890978926 no 2963 0.133973468271294 4190 17173641
SGTC_1757 st041620 31.8375 µM -1.10858145090163 0.133953578931347 no 2964 0.133805391874762 4266 5289815
SGTC_1669 st015249 58.4 µM -1.108657137689 0.133937320827151 no 2965 0.133789059542737 4280 722793
SGTC_2596 sinensetin 100 µM -1.10970883006457 0.133711549544181 no 2966 0.133562258319926 4225 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3248 9135562 49.47 µM -1.11197514424246 0.133225920015331 no 2967 0.133074418732608 4193 17650701
SGTC_3225 9130819 49.47 µM -1.11382863736997 0.132829653698642 no 2968 0.132676354449972 4147 4547121
SGTC_892 0929-0076 29 µM -1.11402763433644 0.132787157574144 no 2969 0.132633665798903 4183 5751038
SGTC_3136 9095672 49.47 µM -1.11416084028458 0.132758716460104 no 2970 0.132605095865221 3933 17217380
SGTC_2248 tofa 1.1 µM -1.1143644604597 0.132715249148095 no 2971 0.132561431723402 4175 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3195 9113082 49.47 µM -1.11613645695931 0.132337390415748 no 2972 0.132181864445447 4196 17018038
SGTC_1005 4092-0690 4.4 µM -1.11703676498301 0.132145693989254 no 2973 0.131989302942495 4228 1529343
SGTC_2504 purpurogallin 52.29 µM -1.12369397253101 0.130734162388679 no 2974 0.13057143716437 4108 5281571 An antioxidant.
SGTC_1686 st019653 115.5 µM -1.1242363427714 0.13061962420708 no 2975 0.130456387775939 4205 97252
SGTC_307 1501-1223 22.3 µM -1.12548858472239 0.130355439830701 no 2976 0.130191025893761 4254 2830329
SGTC_2196 6573537 42.6665 µM -1.12713987796433 0.130007633355659 no 2977 0.129841672616374 4231 2903087
SGTC_1158 4092-0494 91.8 µM -1.12884601288505 0.129648951010683 no 2978 0.129481399187326 4320 1148199
SGTC_2825 7998094 58.44 µM -1.13133930779238 0.129126016978089 no 2979 0.128956152938093 4215 2987815
SGTC_1641 st009299 47.1 µM -1.13153402149852 0.129085240126031 no 2980 0.128915196160307 4155 4046054
SGTC_706 4262-0057 46.9 µM -1.13351850634781 0.128670159426733 no 2981 0.128498287031466 4228 883298
SGTC_2221 6807166 181.081 µM -1.13379582267299 0.128612228962641 no 2982 0.128440101832611 4193 674925
SGTC_1154 4088-0362 150 µM -1.13392826470711 0.128584568646406 no 2983 0.128412319925895 4226 6618304
SGTC_979 1426-2828 121 µM -1.13521913157576 0.128315189282546 no 2984 0.128141757727261 4324 747872
SGTC_2402 5553605 200 µM -1.13568313940698 0.128218455479265 no 2985 0.128044599752595 4315 6758546
SGTC_795 0685-0265 78 µM -1.13889774275843 0.127549683388285 no 2986 0.127372903606878 4240 302754
SGTC_2113 5491891 107.031 µM -1.14030459001071 0.127257764577387 no 2987 0.127079713106193 4230 789979
SGTC_2407 paclitaxel 400 µM -1.14166640520873 0.12697563286565 no 2988 0.126796355045377 4329 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3194 9111903 49.47 µM -1.14171375870239 0.126965830325932 no 2989 0.126786509944626 4270 17087251
SGTC_116 0155-0182 31.788 µM -1.1423341749739 0.126837448013407 no 2990 0.126657570514567 4125 771486
SGTC_1327 1436-0082 2.18 µM -1.14245306867309 0.126812855744806 no 2991 0.126632871590488 4240 15992205
SGTC_3327 9140648 26.9345 µM -1.14288966316969 0.126722577931481 no 2992 0.126542202420909 4254 8029710
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.14567970053653 0.126146718467833 no 2993 0.125963853059002 4231 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2035 5154463 94.595 µM -1.14797031839668 0.125675303949539 no 2994 0.125490408602032 4255 2769623
SGTC_2736 butenafine 14.65 µM -1.14985238053483 0.125288892031085 no 2995 0.125102338419439 4172 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2426 5582046 32.21 µM -1.15326651277892 0.124590044941592 no 2996 0.124400505279062 4260 2251934
SGTC_858 0438-0351 2.77 µM -1.15475179859307 0.124286870325926 no 2997 0.124096040494096 4216 2799119
SGTC_1509 1326-1131 80 µM -1.15664678478545 0.123900817840085 no 2998 0.123708349768903 4208 768313
SGTC_1501 4491-0275 38.4 µM -1.16532168482287 0.122144258436137 no 2999 0.121944402324752 4232 5104718
SGTC_3277 9138724 49.47 µM -1.16784017336731 0.121637586818593 no 3000 0.12143562001303 4215 15943418
SGTC_3218 9131285 49.47 µM -1.17044954835918 0.121114190476649 no 3001 0.120910052990349 4250 17156417
SGTC_2139 5578692 56.4705 µM -1.17094714330407 0.121014561502852 no 3002 0.120810011946073 4227 650991 YMR113W FOL3
SGTC_3226 9131256 49.47 µM -1.17317484647417 0.120569235437861 no 3003 0.120362848391626 4218 17178073
SGTC_2110 5483698 200 µM -1.17343537462188 0.120517230365234 no 3004 0.120310629207746 4240 2848765 YHR062C RPP1
SGTC_2650 prasterone 100 µM -1.1735180434193 0.12050073181555 no 3005 0.120294062752113 4252 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1796 st049173 110.4 µM -1.17390488011231 0.120423550371345 no 3006 0.120216563770678 4228 94134
SGTC_2493 resveratrol 26.09 µM -1.17493801428011 0.120217590699429 no 3007 0.120009757811525 4180 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_117 lucigenin 22.078 µM -1.17494810346783 0.120215580601565 no 3008 0.120007739461822 4259 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_402 epigallocatechin gallate 10 µM -1.176192221225 0.119967892924952 no 3009 0.119759036112745 4206 65064 An antioxidant.
SGTC_1176 0848-0131 83.3 µM -1.17826655328116 0.119555720675652 no 3010 0.119345178699907 4317 6769040
SGTC_2451 5856223 45.7 µM -1.1790112177238 0.119407998917382 no 3011 0.119196854507269 4234 2179896
SGTC_1704 st028805 70.8 µM -1.18133608283355 0.118947635933922 no 3012 0.118734619270553 4306 2876101
SGTC_1273 0849-0096 14.1 µM -1.18258938056408 0.118699982200342 no 3013 0.118485961612295 4287 5286025
SGTC_1467 k284-1082 293 µM -1.18423716341113 0.11837493218495 no 3014 0.118159597404311 4242 3334705
SGTC_2625 euphol 100 µM -1.18526060326784 0.118173360293272 no 3015 0.117957212537251 4284 6708538 A triterpene alcohol.
SGTC_1552 6-methylflavone 10.6 µM -1.18607764891566 0.118012613161215 no 3016 0.117795818178123 4219 689013
SGTC_2346 9031566 143.75 µM -1.19046693241468 0.117151704420013 no 3017 0.116931459724353 4243 4771086
SGTC_798 1287-0182 476 µM -1.19278557370339 0.116698729173472 no 3018 0.116476680700525 4326 1649755
SGTC_1913 st060213 96.1 µM -1.19354895239417 0.116549865794825 no 3019 0.11632722625344 4300 688959
SGTC_1173 0443-0020 122 µM -1.19433210495415 0.116397286399014 no 3020 0.116174041918151 4269 5331295
SGTC_366 0181-0206 4.31 µM -1.19834040174532 0.115618579889332 no 3021 0.115392262028691 4306 274874
SGTC_2920 7982904 15.77 µM -1.20069035980925 0.115163769497024 no 3022 0.114935667498197 4291 6456808
SGTC_2034 5197015 53.07 µM -1.20394482042323 0.114536004632886 no 3023 0.114305453336641 4297 780676
SGTC_646 4092-0839 27.3 µM -1.208228396485 0.113713447995311 no 3024 0.113479710962622 4311 877796
SGTC_421 streptovitacin 30 mM -1.208646763063 0.113633337153228 no 3025 0.11339929129189 4327 91467 include heat shock
SGTC_1455 4262-0120 131 µM -1.20933528715055 0.113501582864197 no 3026 0.11326702964559 4349 1529587
SGTC_2148 5546263 113.568 µM -1.20960628012776 0.113449756195521 no 3027 0.113215003593951 4282 792097
SGTC_1922 5578187 25 µM -1.20961392650503 0.11344829409155 no 3028 0.113213535866663 4316 1350412
SGTC_2737 bleomycin 30.5 nM -1.20978515867722 0.113415555408112 no 3029 0.113180671291219 4387 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2291 7917025 104.35 µM -1.21229373103763 0.112936701931536 no 3030 0.112699981368825 4186 2964612
SGTC_1901 st060216 58.6 µM -1.21284253678406 0.112832134804819 no 3031 0.112595014445954 4261 688792
SGTC_1071 trifluoperazine 6.31 µM -1.21368881014133 0.11267102495971 no 3032 0.112433289486951 4363 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2203 7227154 166.4 µM -1.21435685967384 0.112543960670132 no 3033 0.112305740809582 4309 896304
SGTC_2741 miltefosine 3.04 µM -1.21564832760241 0.112298611285681 no 3034 0.112059457970424 4317 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_857 0438-0306 1.35 µM -1.21724195668518 0.111996385314714 no 3035 0.111756085519375 4365 4686136
SGTC_1754 st042065 16.137 µM -1.21926929798608 0.111612748482239 no 3036 0.111370998754358 4071 1126236 YIL048W NEO1
SGTC_2670 beta-carotene 100 µM -1.21965673325626 0.11153954066185 no 3037 0.111297514935033 4249 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.22257374420807 0.110989459983611 no 3038 0.110745367472914 4318 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2854 9024559 71.43 µM -1.22360057469698 0.110796286697707 no 3039 0.110551471357036 4322 3163529
SGTC_2879 9041815 71.43 µM -1.2239694440986 0.110726951700595 no 3040 0.110481877294784 4317 4942971
SGTC_1309 pyrazolanthrone 13.4 µM -1.22421637856994 0.110680553732116 no 3041 0.110435306075263 4271 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2980 9014342 25.29 µM -1.22476283882017 0.110577925643663 no 3042 0.110332295089348 4357 2996599
SGTC_826 1683-5028 118 µM -1.22549640792811 0.110440264801276 no 3043 0.11019412133387 4346 722377
SGTC_1931 st074438 57.1 µM -1.23336672285252 0.10897105532565 no 3044 0.108719487254288 4316 2787313
SGTC_1004 4084-0029 199 µM -1.23801042455897 0.108110799515639 no 3045 0.107856097752954 4328 716894 YLR208W SEC13
SGTC_2250 alverine citrate 130 µM -1.23815403916794 0.10808427275972 no 3046 0.107829474871635 4195 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1827 berberine 7.24 µM -1.23828769702016 0.108059589305844 no 3047 0.107804701999199 4235 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_719 2810-4230 27.3 µM -1.23885914689337 0.107954101758309 no 3048 0.107698832607379 4330 721079
SGTC_3001 9076041 71.4286 µM -1.24309009164052 0.107175391319518 no 3049 0.106917318299181 4311 16004211
SGTC_109 0132-0036 33.701 µM -1.24537299561465 0.10675690638053 no 3050 0.106497337454171 4157 67274 A color developer.
SGTC_2174 5790901 200 µM -1.24959609855248 0.105985869412783 no 3051 0.105723564520904 4316 786020
SGTC_390 dec-rvkr-cmk 16.7 µM -1.2497738612242 0.105953502713074 no 3052 0.105691083545402 4373 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1088 bifonazole 369 nM -1.25274929756842 0.105412800792972 no 3053 0.10514847948525 4307 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1635 st007035 42.4 µM -1.25385612458633 0.105212176278813 no 3054 0.104947152513482 4298 3716403
SGTC_3308 9128332 17.569 µM -1.25460397975061 0.105076775844842 no 3055 0.104811279014702 4325 17332805 YDL196W YDL196W
SGTC_581 0958-0271 211 µM -1.25558399164712 0.104899534024735 no 3056 0.104633419188957 4333 4591145
SGTC_12 0849-0099 9.267 µM -1.25774523210128 0.104509424221213 no 3057 0.104241954144081 4260 6071388
SGTC_1938 st074717 56.4 µM -1.25900265536515 0.104282940103939 no 3058 0.104014686381893 4204 17250979
SGTC_1332 1480-0653 17.5 µM -1.25986122167109 0.104128501667863 no 3059 0.103859714918487 4336 5749438
SGTC_458 nppb 133 µM -1.25989753265787 0.104121973724062 no 3060 0.103853164468117 4390 4549 A chloride channel blocker.
SGTC_2062 5245942 200 µM -1.26306252834208 0.103554114226073 no 3061 0.103283354594054 4376 1376160
SGTC_3166 9102297 49.47 µM -1.26361078790259 0.103455975011906 no 3062 0.103184879807263 4334 25237072
SGTC_405 ebelactone b 50 µM -1.2639235778744 0.103400015429831 no 3063 0.103128729077841 4275 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1146 3579-1023 7 µM -1.26443760607855 0.103308101120197 no 3064 0.103036501119109 4360 X1146
SGTC_935 2996-0153 430 µM -1.26610532424704 0.10301030188277 no 3065 0.102737688345791 4336 23738523
SGTC_2949 9072542 2.23 µM -1.2674857501948 0.1027642756095 no 3066 0.1024908278367 4353 16457352
SGTC_2759 disulfiram 3.38 µM -1.2729995726196 0.101785834353422 no 3067 0.101509096757075 4259 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2963 9082507 9 µM -1.27361679703933 0.101676729864217 no 3068 0.101399628206907 4362 16459611
SGTC_1297 1068-0111 14.1 µM -1.27796655481528 0.100910252942578 no 3069 0.100630609573233 4343 767057
SGTC_2376 9072922 81.32 µM -1.27809764145723 0.100887219549797 no 3070 0.100607500231523 4352 17087968
SGTC_1962 st076595 64.5 µM -1.27994612335777 0.100562828603876 no 3071 0.10028204235021 4324 279619
SGTC_2648 atorvastatin 78.68 µM -1.28167786477144 0.100259615465015 no 3072 0.0999778364901549 4350 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_213 1246-0773 967 nM -1.28232838294789 0.100145887872521 no 3073 0.0998637376931812 4379 6251622
SGTC_1492 4158-0558 28.5 µM -1.28325438268323 0.0999841613899353 no 3074 0.0997014844129088 4363 3967268
SGTC_3119 9125183 49.47 µM -1.28378644406495 0.099891322827581 no 3075 0.0996083440149243 4190 22695334
SGTC_3031 9088762 49.47 µM -1.28386991912588 0.099876763109826 no 3076 0.0995937369986082 4318 205253
SGTC_435 c-PAF 6.7 µM -1.28765751709317 0.0992177601823322 no 3077 0.0989326040162163 4314 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1430 4049-0248 69.1 µM -1.29334197458222 0.0982346987939276 no 3078 0.0979464046424455 4383 22774488
SGTC_3073 9114972 49.47 µM -1.29439096655381 0.0980540702100863 no 3079 0.0977652046719379 4361 41905075
SGTC_2325 6158266 200 µM -1.29532867414642 0.0978928100732451 no 3080 0.0976034357870932 4354 3623240
SGTC_1286 0929-0070 131 µM -1.301634673269 0.0968133966333825 no 3081 0.0965206504932979 4438 1420408
SGTC_2794 7785382 27.27 µM -1.30540758421459 0.0961717711679236 no 3082 0.0958770486162762 4360 2205081
SGTC_3252 9135871 49.47 µM -1.30704781363306 0.0958938089100242 no 3083 0.0955982366647843 4387 17682838
SGTC_3199 9111318 49.47 µM -1.30920624413059 0.0955289304532595 no 3084 0.0952322488433586 4294 8548020
SGTC_1387 3342-1166 1.8 µM -1.30983228714677 0.0954232905111992 no 3085 0.0951262889975076 4345 3418228
SGTC_373 0844-0104 25.9 µM -1.31099515740346 0.0952272933579987 no 3086 0.0949296998446425 4393 5375804
SGTC_45 0kpi-0036 14.9 µM -1.31796854680874 0.0940581718702915 no 3087 0.0937570886372702 4374 2795021
SGTC_987 1497-1013 404 µM -1.31797976217479 0.0940563001302882 no 3088 0.0937552113677521 4387 1676435
SGTC_2747 doxorubicin 7.63 µM -1.31928221533768 0.09383911971831 no 3089 0.0935373906148122 4404 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1946 st076057 65.1 µM -1.32091959557138 0.0935666166146088 no 3090 0.0932640875861827 4338 953009
SGTC_2001 4023502 57.655 µM -1.32277921525637 0.0932578362740575 no 3091 0.0929544055985657 4397 108941 YCR052W RSC6
SGTC_1082 camptothecin 424.86 nM -1.32395353987844 0.093063233911253 no 3092 0.0927592376042631 4255 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1429 4049-0205 9.46 µM -1.32397011728366 0.093060488948466 no 3093 0.0927564846774486 4430 22774478
SGTC_125 0133-0007 11.75 µM -1.32454536469837 0.0929652739075989 no 3094 0.0926609936366364 4463 26541
SGTC_1897 st060201 15 µM -1.32568780871163 0.0927763899717232 no 3095 0.0924715636217771 4401 611878
SGTC_281 1672-3440 14.9 µM -1.33144526009579 0.0918288095017517 no 3096 0.0915212726791634 4413 6833000
SGTC_2941 9056145 11.23 µM -1.33165265824714 0.0917948094932628 no 3097 0.0914871763225244 4306 2119517
SGTC_176 1486-1328 72.834 µM -1.33378708045823 0.0914454426706576 no 3098 0.0911368231356777 4434 22310231
SGTC_2983 9022671 12.99 µM -1.33735133288206 0.0908642367528156 no 3099 0.0905539911586023 4383 6405161
SGTC_2306 7482397 179.52 µM -1.33869279360643 0.0906462024094958 no 3100 0.0903353516274522 4414 891448
SGTC_1876 myriocin 605 nM -1.33943087007012 0.0905264048683378 no 3101 0.0902152226931338 4386 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_492 tmb-8 126 µM -1.34229813931478 0.0900621321757626 no 3102 0.0897496732513626 4411 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_959 1222-0044 107 µM -1.34277062379805 0.0899857968397197 no 3103 0.0896731291473169 4380 6083612
SGTC_376 3970-0862 59.1 µM -1.34312038149893 0.0899293204110738 no 3104 0.0896164984728065 4427 3135186
SGTC_1521 st012942 49.4 µM -1.34423749650331 0.0897491129200069 no 3105 0.0894358000055774 4341 24207259
SGTC_2580 diallyl disulphide 81.36 µM -1.34446911116207 0.0897117836063467 no 3106 0.0893983692165054 4386 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_784 4579-0127 173 µM -1.34532919784986 0.0895732645294898 no 3107 0.0892594742782072 4433 1948547
SGTC_1135 dihydrocapsaicin 536.708 nM -1.34641903558791 0.089397972009172 no 3108 0.0890837076677818 4306 107982 A Capsaicinoid.
SGTC_1372 2752-0194 270 µM -1.35436442967533 0.0881277175388781 no 3109 0.0878100699917541 4341 823334
SGTC_1369 1866-0067 208 µM -1.35680983377221 0.0877394841087163 no 3110 0.0874208210458467 4421 3531355
SGTC_1764 st044502 93.5 µM -1.35764867087519 0.0876066042819239 no 3111 0.0872875956497587 4425 8407
SGTC_2541 muurolladie-3-one 83.07 µM -1.35975740489622 0.0872732239348265 no 3112 0.0869533528389419 4363 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_298 1391-0729 10 µM -1.36367678210063 0.0866561076719509 no 3113 0.0863346572728881 4352 3237558
SGTC_2309 7664088 163.95 µM -1.36520611327644 0.0864161970574881 no 3114 0.0860941387517611 4404 704922
SGTC_3260 9137109 49.47 µM -1.36556145902762 0.0863605241099678 no 3115 0.0860383252229349 4359 17478346
SGTC_1900 st060200 72.8 µM -1.36719557332847 0.0861048483831653 no 3116 0.0857820062484246 4399 688945
SGTC_2403 6032726 181.2 µM -1.37050457391444 0.0855888527227708 no 3117 0.0852647242959851 4434 2881040
SGTC_3294 9122953 26.2835 µM -1.37161856908287 0.0854156616288351 no 3118 0.0850911050466731 4384 16459826
SGTC_212 3807-4682 38.772 µM -1.37164793537104 0.0854110996514449 no 3119 0.0850865318157852 4483 3125501 YBL034C STU1
SGTC_3205 9113483 49.47 µM -1.38238454840815 0.083755397479518 no 3120 0.0834268289569569 4433 17018033
SGTC_2976 9009005 19.48 µM -1.3850264109256 0.0833517142281048 no 3121 0.0830221958482996 4428 2993148
SGTC_1620 st003704 16.5 µM -1.38641838636296 0.0831396060611363 no 3122 0.0828095926619776 4419 2834414
SGTC_2543 pimpinellin 60.67 µM -1.38727426804079 0.0830093891176802 no 3123 0.0826790732107639 4283 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1153 4055-0057 267 µM -1.38797755884107 0.082902502768698 no 3124 0.0825719393475652 4469 882706
SGTC_1540 guanosine 70.6 µM -1.38882349318726 0.08277407461829 no 3125 0.0824432147479222 4353 6802 Guanosine is a purine nucleoside
SGTC_2308 7584454 197.62 µM -1.39036825825113 0.0825399376956926 no 3126 0.0822085400417865 4443 893577
SGTC_2999 9069765 71.4286 µM -1.39148466270325 0.0823710371174728 no 3127 0.0820392536687795 4387 2097066
SGTC_11 0438-0307 1.3 µM -1.39165490230574 0.0823453044908422 no 3128 0.0820134624233655 4411 4011476
SGTC_468 gf-109203x 121 µM -1.39325249066794 0.0821041153460636 no 3129 0.0817717258929605 4484 2396 A protein kinase C inhibitor.
SGTC_2369 9071472 200 µM -1.39842115513227 0.081327443944815 no 3130 0.0809933170319915 4454 17296037
SGTC_175 3793-3120 23.7 µM -1.40070229458148 0.0809864356504924 no 3131 0.0806515581314198 4425 5322297
SGTC_1792 st045773 43.6 µM -1.40216435128576 0.0807684405389289 no 3132 0.080433087127988 4400 2919270
SGTC_102 gallobenzophenone 83.616 µM -1.41228355804619 0.0792717794746644 no 3133 0.0789332428360378 4426 70837
SGTC_2073 5212005 126 µM -1.4254570259642 0.0773549617651986 no 3134 0.0770125669640248 4339 691789
SGTC_3107 9121808 49.47 µM -1.42697041348808 0.0771370290215704 no 3135 0.0767942114377692 4406 662681
SGTC_2915 7971052 15.16 µM -1.43256029691579 0.076336110484011 no 3136 0.0759917674518674 4383 5741558
SGTC_588 3970-1144 52.9 µM -1.43551628058811 0.0759151430185126 no 3137 0.0755700161943418 4344 1888707
SGTC_332 4112-0506 40.9 µM -1.44087298354053 0.0751567920578851 no 3138 0.0748102849170039 4444 2790355
SGTC_1137 ixabepilone 100 µM -1.44150516726706 0.0750676759395852 no 3139 0.0747210092854569 4406 154225 A novel microtubule stabilizer.
SGTC_1147 3809-1045 12.3 µM -1.44512345241864 0.0745591722246346 no 3140 0.0742116062931511 4471 325925
SGTC_1380 2291-0730 164 µM -1.44900416213469 0.0740167147555716 no 3141 0.0736682101200257 4458 2999191
SGTC_1609 st001574 46.4 µM -1.44901443319774 0.0740152830466043 no 3142 0.0736667759618739 4453 3960012
SGTC_2046 4110841 106 µM -1.45383169320697 0.0733461225119644 no 3143 0.0729964871612582 4471 44119630 YMR134W ERG29
SGTC_862 0452-0056 10.2 µM -1.45461110639013 0.0732382913428464 no 3144 0.0728884772641895 4420 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3315 9136395 68.55 µM -1.45560917185538 0.0731003869552946 no 3145 0.072750345557641 4454 16876844
SGTC_1351 1496-0003 46.5 µM -1.46074958948145 0.0723932720704971 no 3146 0.0720420873274649 4491 3891978
SGTC_1800 st050079 29.0735 µM -1.46255659925069 0.0721459489802748 no 3147 0.0717943731839638 4287 3645560
SGTC_220 paclitaxel 373.376 µM -1.46363687805016 0.0719984022555779 no 3148 0.071646595364879 4449 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2525 harmine 47.85 µM -1.46448961876511 0.0718820966350235 no 3149 0.0715301087425463 4456 5280953 A monoamine oxidase inhibitor
SGTC_17 0960-0276 49.807 µM -1.46474583759002 0.0718471790188422 no 3150 0.0714951369856736 4475 6821114
SGTC_293 4049-0273 38.5 µM -1.47014193942268 0.071114814001052 no 3151 0.0707616578353873 4346 1380311
SGTC_1872 amphotericin b 148 nM -1.47392002210007 0.0706054698138111 no 3152 0.0702515630876427 4488 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1854 st056233 32.9 µM -1.47422994784296 0.0705638117702104 no 3153 0.0702098445461307 4399 5393174
SGTC_1718 roemerine 11.9335 µM -1.48723506813342 0.0688327292540467 no 3154 0.0684763685495112 4106 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2570 licareol 100 µM -1.48946479629076 0.0685392512712775 no 3155 0.0681825084175071 4448 443158
SGTC_2636 apigenin dimethyl ether 100 µM -1.49424739079478 0.0679130200686412 no 3156 0.0675554850589203 4466 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_705 1124-0212 310 µM -1.49455472864148 0.0678729289537172 no 3157 0.0675153443169256 4489 9554485
SGTC_2442 5158906 48.48 µM -1.49774276327785 0.0674581387440507 no 3158 0.0671000483826657 4499 1893835
SGTC_1189 1431-2119 7.28 µM -1.50421364281695 0.0666222493701707 no 3159 0.0662631830295328 4480 3107275
SGTC_635 k038-0028 24.7 µM -1.51578758839094 0.065147181133682 no 3160 0.0647865357257212 4513 4035102
SGTC_3153 9100258 49.47 µM -1.51713533383199 0.064977075002945 no 3161 0.0646162594421491 4431 25236848
SGTC_2831 7999036 19.48 µM -1.51860360897107 0.0647921487929577 no 3162 0.0644311510913056 4473 2988270
SGTC_19 0279-0214 38.434 µM -1.5202822350417 0.0645812302852771 no 3163 0.06422002846193 4572 3566274 YBR002C RER2
SGTC_841 0251-0215 91.2 µM -1.52294863929664 0.0642472948666897 no 3164 0.0638857777954684 4551 3888614
SGTC_2576 guaiol 23.12 µM -1.53411191079457 0.0628637801154097 no 3165 0.0625010617960569 4410 227829
SGTC_1335 1486-0900 202 µM -1.53440441515899 0.0628278432941053 no 3166 0.0624650960493932 4509 X1335
SGTC_2089 5281248 129.67 µM -1.53445269992253 0.0628219126113732 no 3167 0.0624591606042752 4495 2737878
SGTC_1056 3448-1962 115 µM -1.54222133878818 0.0618733807872484 no 3168 0.0615099081730647 4479 715507
SGTC_1410 3909-8106 77.9 µM -1.54280695995952 0.0618023334218695 no 3169 0.0614388101414822 4572 1039210
SGTC_1561 5-methoxyflavone 52.9 µM -1.54311371682448 0.0617651432053488 no 3170 0.061401593588599 4480 94525
SGTC_1801 st050089 28.441 µM -1.54602933079652 0.0614125351418739 no 3171 0.0610487421681124 4563 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3116 9124943 49.47 µM -1.55215798780833 0.0606764765907568 no 3172 0.0603122128848967 4507 41905195 YPL160W CDC60
SGTC_2899 9053889 58.44 µM -1.55358420076677 0.0605061805457635 no 3173 0.0601418151709971 4518 6470052
SGTC_1155 4088-0394 48.2 µM -1.55436909567139 0.0604126203305437 no 3174 0.0600482002651908 4518 2326248
SGTC_3081 9117243 49.47 µM -1.55823309894627 0.0599536770292513 no 3175 0.0595890007259553 4490 45595589
SGTC_1911 st060208 74.3 µM -1.56025935100246 0.0597141046543817 no 3176 0.0593493025805127 4534 688783
SGTC_2783 7738165 71.43 µM -1.57329201615607 0.0581910800622141 no 3177 0.0578256085785121 4512 17201110
SGTC_173 1273-0061 2.693 µM -1.57382546001049 0.0581293969540922 no 3178 0.0577639031593219 4483 2847414 YPL266W DIM1
SGTC_1279 0874-0590 65.2 µM -1.57396440039841 0.0581133394539338 no 3179 0.0577478399130911 4601 3523074
SGTC_3297 9117502 71.43 µM -1.5770197178537 0.057761113187814 no 3180 0.0573954940676607 4554 7453720
SGTC_1554 st069299 38.7 µM -1.57859411691565 0.0575802681658835 no 3181 0.0572145924713131 4485 24207999
SGTC_2940 9060638 45.86 µM -1.58040486303323 0.05737282584201 no 3182 0.057007089302576 4512 4027022
SGTC_2839 9003951 25.97 µM -1.58156792889055 0.0572398933733796 no 3183 0.0568741201272057 4590 2990634
SGTC_2528 xanthyletin 44.79 µM -1.5832906192994 0.0570434442311642 no 3184 0.0566776200178265 4561 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1151 3909-8316 15.3 µM -1.5890820265286 0.0563869034865156 no 3185 0.0560209375169981 4573 800431
SGTC_274 sirtinol 40.1 µM -1.59231676038416 0.0560227998896471 no 3186 0.0556567744378075 4574 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_500 h-89 112 µM -1.59396895870592 0.0558375442459358 no 3187 0.0554714938155876 4513 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2488 5268135 45.7 µM -1.59647987347752 0.0555569293255723 no 3188 0.0551908478908985 4562 1270356 YLR208W SEC13
SGTC_78 0336-0123 156.75 µM -1.60082727639523 0.0550737056251564 no 3189 0.0547075902251132 4411 6765896
SGTC_544 k015-0020 52.4 µM -1.60307643541694 0.0548250131484692 no 3190 0.0544588899194597 4577 3008304
SGTC_3133 9127736 49.47 µM -1.60823288239024 0.054258208332272 no 3191 0.0538920920076916 4545 27243420
SGTC_2167 5876490 200 µM -1.60929885077153 0.0541416157439347 no 3192 0.0537755051355831 4552 686534
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.61549924877974 0.0534673599493385 no 3193 0.0531013114442471 4540 442882
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.62024703244336 0.0529555789510432 no 3194 0.0525896109777578 4583 94937 An inhibitor of serotonin biosynthesis.
SGTC_1427 4048-4900 550 nM -1.63109886832229 0.0518004080628507 no 3195 0.051434729724201 4539 24132586
SGTC_3162 9099653 49.47 µM -1.63222863984919 0.0516813046527749 no 3196 0.0513156647965681 4540 25237511
SGTC_408 cantharidin 100 µM -1.63633819265479 0.0512499002908438 no 3197 0.0508844134911505 4550 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2151 5563267 85.4165 µM -1.63779831077564 0.0510973145514624 no 3198 0.0507318870444851 4612 5310824
SGTC_712 r015-0009 80.6 µM -1.63981854947607 0.0508867913246065 no 3199 0.0505214500762274 4593 6813872 YLR060W FRS1
SGTC_2362 9071156 126 µM -1.64811273331083 0.0500297061751148 no 3200 0.0496647699184564 4568 653133
SGTC_2477 5967686 25.23 µM -1.65260513670094 0.0495703091676756 no 3201 0.0492056259935544 4565 776118
SGTC_861 0443-0273 110 µM -1.65278933338698 0.0495515451445567 no 3202 0.0491868728475267 4558 6149169
SGTC_1061 3448-9325 110 µM -1.65566637606728 0.0492591973810894 no 3203 0.0488947000596828 4540 723482
SGTC_3129 9127257 49.47 µM -1.6569514526591 0.0491290613926852 no 3204 0.048764645301711 4506 837894
SGTC_2008 4012253 172 µM -1.65816607139664 0.049006313033506 no 3205 0.0486419754566862 4573 603940
SGTC_1031 k035-0009 16 µM -1.66069019825618 0.0487520105296472 no 3206 0.0483878414918168 4600 5180959
SGTC_1191 1487-1166 10.6 µM -1.66391796970626 0.048428354714004 no 3207 0.0480644117131223 4584 3955771
SGTC_2692 st077426 47.7 µM -1.6783488467606 0.0470022993343425 no 3208 0.0466395087167852 4561 25238571
SGTC_1395 3486-0190 4.35 µM -1.6807717746183 0.0467662013474693 no 3209 0.0464036265375115 4563 6748079
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.68152105332967 0.0466933820945064 no 3210 0.0463308753010082 4580 688662
SGTC_2639 lactacystin 53 µM -1.68786090753637 0.0460808735083581 no 3211 0.0457189661980719 4587 3870 A proteasome inhibitor.
SGTC_381 3461-2219 42.7 µM -1.69330704877747 0.0455598770440925 no 3212 0.0451985185633751 4567 2883159
SGTC_3173 9105693 49.47 µM -1.69972184094436 0.0449523021235108 no 3213 0.0445916295470149 4572 17096658
SGTC_2669 eugenol 100 µM -1.70130660858672 0.0448032104708098 no 3214 0.0444427138389575 4622 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1127 asiatic acid 681.4 nM -1.70307936417798 0.0446369053755461 no 3215 0.0442766085795879 4534 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3137 9097352 49.47 µM -1.70545928229905 0.0444144235672684 no 3216 0.0440544000382428 4568 44120435
SGTC_3331 9141060 1.957 µM -1.70581981887078 0.0443807976069047 no 3217 0.0440208159719279 4559 4906567 YPR165W RHO1
SGTC_108 0509-0257 621.132 µM -1.71012881310798 0.0439804987771573 no 3218 0.0436210278873393 4564 536624
SGTC_1271 0832-2808 169 µM -1.71705638541857 0.0433430463947718 no 3219 0.0429844350549197 4626 3663794
SGTC_552 k242-0005 476 µM -1.71819311734662 0.0432391640869867 no 3220 0.0428806982599935 4637 4088318
SGTC_2052 5265182 7.135 µM -1.71927910007008 0.0431401074839409 no 3221 0.0427817818401972 4570 1239884
SGTC_1998 st075797 76.8 µM -1.72703530086059 0.0424379535369569 no 3222 0.0420806619227616 4597 24208315
SGTC_1032 k061-1018 98.7 µM -1.72884105323604 0.0422758159041966 no 3223 0.041918773204131 4621 4005393
SGTC_1094 duloxetine 25.4 µM -1.72941669154648 0.0422242350943589 no 3224 0.0418672723858854 4607 60834 A selective serotonin reuptake inhibitor.
SGTC_2707 st078556 66.6 µM -1.73034742157556 0.0421409435761806 no 3225 0.0417841108585024 4520 17250899
SGTC_124 0136-0217 7.121 µM -1.73340747538386 0.0418680345831482 no 3226 0.0415116349290776 4644 3976905
SGTC_155 k072-0202 43.6 µM -1.7406756616849 0.0412255599300153 no 3227 0.0408702233987371 4599 5857737
SGTC_2524 avocatin b 10.57 µM -1.7456942535354 0.0407866216321103 no 3228 0.0404320470844106 4627 6710748
SGTC_2123 5259487 200 µM -1.74655487245404 0.0407117320782075 no 3229 0.0403572904593043 4610 2173474
SGTC_253 dyclonine 31.25 µM -1.74997593061609 0.0404151402843899 no 3230 0.0400612335494628 4694 3180 An oral anasthetic.
SGTC_968 1309-0633 340 µM -1.75260389215602 0.0401885002397982 no 3231 0.039835011365887 4638 3761976
SGTC_943 3253-1379 105 µM -1.75274176173249 0.0401766386847077 no 3232 0.0398231718991476 4578 668464
SGTC_2506 ethyl hematommate 54.16 µM -1.75353761380144 0.0401082234435309 no 3233 0.0397548844858091 4613 3940691 An allergen.
SGTC_2989 9073649 71.4286 µM -1.76305932089208 0.0392970099875658 no 3234 0.0389452425900741 4572 21367202
SGTC_2898 9056270 58.44 µM -1.76775795328075 0.0389016520997933 no 3235 0.0385506884570709 4635 19154699
SGTC_1398 3558-0053 112 µM -1.76903815558206 0.0387944951401849 no 3236 0.0384437536718294 4605 4532369
SGTC_362 0310-0100 9.03 µM -1.76929120358572 0.0387733427112774 no 3237 0.038422645318612 4629 790235
SGTC_1344 1488-0097 29.1 µM -1.7716111908525 0.0385798512233808 no 3238 0.0382295603776283 4648 747966
SGTC_1948 st076329 66.6 µM -1.77308569432048 0.0384572842242466 no 3239 0.0381072540548812 4536 24208413
SGTC_761 k216-0224 480 µM -1.77651400011322 0.0381735354833437 no 3240 0.0378241182238045 4620 1340404
SGTC_1748 st037455 53.6035 µM -1.78495021786416 0.0374825650559515 no 3241 0.0371346960371928 4610 580690
SGTC_1862 st057513 3.81 µM -1.78836753423474 0.03720559126536 no 3242 0.0368583653200667 4623 5393163
SGTC_1687 st020778 55.3625 µM -1.79987603439665 0.0362851018770591 no 3243 0.0359401073089285 4655 4259299
SGTC_917 harmaline 728.087 nM -1.80409795799152 0.0359521270473399 no 3244 0.0356079759002566 4551 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_415 dibenzyl ketone 100 µM -1.80939265959653 0.0355380864110246 no 3245 0.0351950113689674 4615 7593
SGTC_748 act1.228 77.9 µM -1.80988397709917 0.0354998648615524 no 3246 0.035156890699842 4609 4421505 YNR035C ARC35
SGTC_2602 kawain 100 µM -1.82550184134074 0.0343023459143513 no 3247 0.0339626667868993 4600 5369129
SGTC_926 2268-1401 59.4 µM -1.82838428726989 0.03408500165613 no 3248 0.0337459489341826 4598 2931578
SGTC_2614 arthonioic acid 13.39 µM -1.83181547857134 0.0338277580247934 no 3249 0.0334894581777793 4506 6710684
SGTC_1400 3771-8998 51.5 µM -1.83350537636958 0.0337016510772868 no 3250 0.0333637248826911 4625 670767
SGTC_2890 9046729 58.44 µM -1.84681509943429 0.0327218903935727 no 3251 0.0323869713667924 4621 903329
SGTC_708 3448-5400 146 µM -1.84848553919285 0.0326006009486886 no 3252 0.0322660672152796 4593 3462195
SGTC_2745 rifampicin 24.3 µM -1.85402949542501 0.0322007129104278 no 3253 0.0318674701585948 4741 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1871 st057448 67.3 µM -1.86532180714855 0.0313987115631467 no 3254 0.0310681551199359 4639 691747
SGTC_797 k781-0471 270 µM -1.8790304832056 0.0304473628540439 no 3255 0.0301201655284717 4630 23738129
SGTC_1715 st032160 10.2275 µM -1.90191998272306 0.0289121735053169 no 3256 0.0285908081709973 4576 5289825
SGTC_2906 7926292 26.41 µM -1.91450158596117 0.0280960978021257 no 3257 0.0277780483405645 4636 2966319
SGTC_351 caspofungin 25 nM -1.92215088761689 0.0276093851208584 no 3258 0.027293387251632 4656 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2828 7998861 71.43 µM -1.92551647792901 0.027397475252018 no 3259 0.0270823882554725 4673 2988188
SGTC_675 1309-0189 238 µM -1.92744333105742 0.0272767652715288 no 3260 0.0269622019694273 4672 4246530
SGTC_2628 lathosterol 100 µM -1.93029042936485 0.0270992177143313 no 3261 0.0267854311157714 4681 6710616
SGTC_316 k060-0003 58.6 µM -1.93091767849031 0.027060231815434 no 3262 0.0267466167940138 4697 6152314
SGTC_1903 st060211 78.3 µM -1.93815120261591 0.0266140136589293 no 3263 0.0263023890703088 4678 688960
SGTC_1017 4239-0030 168 µM -1.95553366205966 0.0255668139229924 no 3264 0.0252600570970643 4673 1149593
SGTC_41 0478-0632 82.643 µM -1.95593647416836 0.0255429616553089 no 3265 0.0252363189845543 4640 3750424
SGTC_1428 4049-0204 61.7 µM -1.95768691439305 0.0254395267437732 no 3266 0.0251333808248407 4701 X1428
SGTC_2820 7989630 71.43 µM -1.96875903494082 0.0247933629293688 no 3267 0.0244903842564165 4699 2984098
SGTC_3132 9126706 49.47 µM -1.97428824052624 0.0244758699981402 no 3268 0.0241744886353554 4666 850858
SGTC_629 3448-6466 76.7 µM -1.97627126885262 0.0243628369697481 no 3269 0.0240620309185216 4699 573744
SGTC_270 tamoxifen 5.46 µM -1.97846641021465 0.0242382248774779 no 3270 0.0239380571483265 4675 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1976 st070609 63.5 µM -1.98614281386211 0.0238066579096153 no 3271 0.0235087342495635 4648 682556
SGTC_3157 9099274 49.47 µM -1.98807774521659 0.023698901309277 no 3272 0.0234015461292675 4680 17217662
SGTC_749 1000-0129 128 µM -1.99549988547289 0.0232893576966211 no 3273 0.0229941933156334 4698 708470
SGTC_2345 9052315 157.45 µM -2.01065023130296 0.0224718522661228 no 3274 0.02218120716983 4675 6469265
SGTC_2557 derrustone 83.84 µM -2.01142609962296 0.0224306464669524 no 3275 0.0221402344241258 4664 629853 An antioxidant.
SGTC_1218 1348-1416 30.7 µM -2.01533607392854 0.0222239590853123 no 3276 0.0219347237873236 4671 6787668
SGTC_2069 5228469 200 µM -2.02197771714466 0.0218765549436367 no 3277 0.0215893269629144 4668 2835210
SGTC_1342 1486-1464 234 µM -2.02545898292124 0.0216962998166229 no 3278 0.0214101280766834 4708 3253938
SGTC_2257 7960413 200 µM -2.02563591732789 0.0216871720047986 no 3279 0.0214010540210302 4717 2974689 YIL048W NEO1
SGTC_886 0866-0150 153 µM -2.03944674048772 0.0209846320428409 no 3280 0.0207027307912508 4714 271463
SGTC_2118 5526350 200 µM -2.0458851408068 0.0206637586214907 no 3281 0.0203838363112517 4691 743594
SGTC_321 4534-3890 65.3 µM -2.06018705060823 0.0199658307681555 no 3282 0.0196903311922334 4709 699746
SGTC_1560 lithocholic acid 53.1 µM -2.06953440093377 0.0195205742991235 no 3283 0.0192479833109575 4664 9903 A bile acid which acts as a detergent.
SGTC_1284 0929-0043 16 µM -2.07457548444468 0.0192839651478173 no 3284 0.0190129480777251 4706 1239883
SGTC_3080 9117754 49.47 µM -2.0753202748993 0.0192492150335084 no 3285 0.0189784307965805 4693 9550191
SGTC_785 1270-0111 65.3 µM -2.08040306713166 0.0190134824229762 no 3286 0.0187442890895679 4636 6741994
SGTC_1106 tegaserod maleate 11.7 µM -2.09328217117411 0.0184271348559718 no 3287 0.0181619866140858 4717 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2954 9074818 52.69 µM -2.11260202867084 0.0175764715452111 no 3288 0.0173174224729567 4698 16648742
SGTC_3150 9097574 49.47 µM -2.11924750890764 0.0172917218744707 no 3289 0.0170347775868185 4717 17217476
SGTC_136 0097-0015 404.482 µM -2.13396163981388 0.016675235338468 no 3290 0.0164229605173356 4701 4861337
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.14562833806795 0.0161998873925649 no 3291 0.0159513213465271 4705 23847180
SGTC_493 zm226600 134 µM -2.15171772874567 0.0159564253533494 no 3292 0.0157097964750278 4710 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2785 7756463 72.73 µM -2.15596027370054 0.0157886625568638 no 3293 0.0155433836551913 4691 2201551
SGTC_545 4218-0007 221 µM -2.16855980720675 0.015299328978476 no 3294 0.0150580597057852 4714 2840508
SGTC_2534 helenine 20.12 µM -2.17143898291899 0.0151893555314124 no 3295 0.0149490024112895 4708 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_519 k048-0011 62.8 µM -2.18115947100155 0.0148230727329567 no 3296 0.0145858116809536 4709 6836379
SGTC_3299 9121982 43.1275 µM -2.1973727894939 0.0142290261636143 no 3297 0.0139969164878856 4713 17594604 YPL160W CDC60
SGTC_2781 5567276 71.43 µM -2.2077332689253 0.0138602601080221 no 3298 0.0136314361217616 4696 2853274
SGTC_734 2023-0417 80 µM -2.2641401443174 0.0119938292987739 no 3299 0.0117827482954642 4732 3935732
SGTC_2150 5556613 200 µM -2.26549147751252 0.0119519281630982 no 3300 0.0117412682122963 4751 743190
SGTC_1955 wogonin 32.4 µM -2.2706467372159 0.0117932416341977 no 3301 0.0115841858776998 4705 5281703 A flavanone.
SGTC_685 1278-0033 54.9 µM -2.27732069306165 0.0115905251462635 no 3302 0.0113835410571919 4746 3590572
SGTC_833 3852-0053 558 µM -2.2775052601088 0.0115849623193805 no 3303 0.0113780354374797 4741 3123681
SGTC_149 3970-0822 46.1 µM -2.2883114547562 0.0112632806820671 no 3304 0.011059694957516 4726 3114250 YBL034C STU1
SGTC_814 3342-0569 96 µM -2.29192729584185 0.0111573909281619 no 3305 0.0109549194355528 4758 4346283
SGTC_2460 5552655 174.22 µM -2.30027118343194 0.0109163384146658 no 3306 0.0107164305936211 4723 5401989
SGTC_1444 4112-3581 28 µM -2.31022194345545 0.0106347996511911 no 3307 0.0104379348939831 4778 2877249
SGTC_939 1165-0479 45.3 µM -2.32207511098049 0.0103077071728213 no 3308 0.0101144457907933 4718 1377347
SGTC_1453 4237-0541 195 µM -2.32522525872404 0.0102222670267863 no 3309 0.010029959200377 4740 739892
SGTC_3093 9117344 49.47 µM -2.32564947200069 0.0102108085891992 no 3310 0.0100186290384199 4749 24824913
SGTC_512 prima-1 270 µM -2.32664906113183 0.0101838529479153 no 3311 0.00999197553050689 4748 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2047 4141938 200 µM -2.33614149353544 0.00993095147753023 no 3312 0.00974193417642179 4754 3807862
SGTC_2262 9014885 67.46 µM -2.34139229707109 0.0097934265017766 no 3313 0.00960598410387923 4763 6457424
SGTC_934 2950-0684 338 µM -2.34954437415739 0.00958320952873207 no 3314 0.00939820176066423 4744 1121253
SGTC_3188 9110789 49.47 µM -2.37060287266721 0.00905833069643556 no 3315 0.00887955053870225 4726 849217
SGTC_196 k015-0023 18.111 µM -2.37937889312005 0.0088471324209688 no 3316 0.00867092022654075 4742 5211998
SGTC_2142 5622915 118.518 µM -2.38685059516701 0.00867073693022617 no 3317 0.00849669784946691 4762 5322196
SGTC_3176 9106582 49.47 µM -2.39733606787797 0.00842839489330024 no 3318 0.00825738447764864 4781 17018027
SGTC_2588 indole-3-carbinol 100 µM -2.39766444840712 0.00842090228873846 no 3319 0.00824998632127852 4731 3712 Induces cell cycle arrest.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.40074337386186 0.00835093487563548 no 3320 0.00818090325921704 4751 165506
SGTC_2581 avocatin a 64 µM -2.41524237575742 0.0080282677947393 no 3321 0.00786237100306284 4694 6710728 A skin care supplement.
SGTC_1799 st045822 46.1415 µM -2.46511138566454 0.007000601383426 no 3322 0.00684853324090305 4758 3674992
SGTC_2447 5741742 33.78 µM -2.46581116562417 0.00698704767473717 no 3323 0.00683516906266207 4770 1776504
SGTC_139 0099-0334 718.624 µM -2.46968328277766 0.00691246835189857 no 3324 0.00676163614467516 4740 97690
SGTC_1825 st052143 62.6 µM -2.49440167834638 0.00645273044566073 no 3325 0.0063084837844419 4777 674173
SGTC_1581 himbacine 57.9 µM -2.55256859959542 0.00547600930280872 no 3326 0.00534659248843646 4777 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2378 9074213 121.43 µM -2.5776417762236 0.00509717646549323 no 3327 0.00497385320742655 4767 657714
SGTC_864 0469-0573 172 µM -2.58081593361015 0.00505092096768488 no 3328 0.004928356016657 4758 689425
SGTC_42 0133-0086 60.653 µM -2.62582055983707 0.00443415278994651 no 3329 0.00432201864848202 4719 162923 Model of phenazepam hydroxylation.
SGTC_357 1325-0123 420 µM -2.62629755678108 0.00442799292092201 no 3330 0.00431596610545956 4763 1098503
SGTC_2375 9072683 200 µM -2.63233596453214 0.00435067209620542 no 3331 0.00423999806166228 4782 16798029
SGTC_2038 4100038 30.985 µM -2.6783796416813 0.00379968397636463 no 3332 0.00369896572515772 4753 3596803
SGTC_1396 3511-0007 98.6 µM -2.69371903559575 0.00363052775118182 no 3333 0.00353298503865202 4778 X1396
SGTC_844 0330-0132 15.3 µM -2.70884851115514 0.00347033764602973 no 3334 0.00337585799798879 4784 2828079
SGTC_1750 st081859 2.357 µM -2.72813691704366 0.00327533192304933 no 3335 0.00318465825293006 4729 5291695
SGTC_3284 9108171 64.8615 µM -2.75575364831442 0.00301327072981372 no 3336 0.00292785411189407 4764 8687505
SGTC_1600 coumarin 106 71.1 µM -2.80964926016283 0.00255557648082514 no 3337 0.00247977580147265 4790 100336 A hepatotoxic, DNA x-linker.
SGTC_2370 9071495 200 µM -2.86817310583454 0.00213054626529662 no 3338 0.00206424790781951 4788 21791103
SGTC_1680 diphenhydramine 100 µM -2.96270061605549 0.00157767675459688 no 3339 0.00152476507490461 4763 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1416 3966-0321 25.3 µM -3.00672905467852 0.00136782859286195 no 3340 0.00132037509998917 4801 582530 YLR208W SEC13
SGTC_1409 3909-8004 61.9 µM -3.01066876757588 0.00135035313203635 no 3341 0.00130336520494058 4798 2119279
SGTC_2791 5663188 71.43 µM -3.10840707455559 0.000977062272479169 yes 3342 0.000940493937727038 4778 54690634
SGTC_505 gw-5074 63.9 µM -3.11146026036462 0.000967098884510857 yes 3343 0.000930822645056128 4793 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1421 4029-0249 71.4 µM -3.28825332005262 0.000526423966985351 yes 3344 0.000504055431240507 4805 2894095
SGTC_2391 6285546 200 µM -3.30532032056108 0.000495645966587857 yes 3345 0.000474339549208408 4800 846083
SGTC_2531 methyl deoxycholate 70.07 µM -3.44108315355051 0.000303989555585171 yes 3346 0.00028969522321031 4777 16667744 Haematoxylin.
SGTC_1426 4048-4480 71.7 µM -3.84566690238738 6.39498207029664e-05 yes 3347 6.01124978909987e-05 4809 14224343
SGTC_2931 9014674 55.67 µM -4.33675152430064 7.83869669020659e-06 yes 3348 7.23019671710759e-06 4803 2996810
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -5.27340277847867 7.57882309151116e-08 yes 3349 6.69586052216987e-08 4809 6708760
SGTC_2539 epi(13)torulosol 80 µM -6.31279910786817 1.64434596110257e-10 yes 3350 1.37016564187831e-10 4808 6708597