SGTCid condition conc unit LAS21|YJL062W.score LAS21|YJL062W.strain.pval LAS21|YJL062W.strain.significant LAS21|YJL062W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3084 9116877 49.47 µM 8.70128726762182 4.394897413364e-18 yes 1 1.64070222046338e-18 1 27241325 SGTC_1921 5740136 50 µM 7.50143888507609 6.64247174245938e-14 yes 2 3.15605293176126e-14 7 1774243 SGTC_800 3448-7362 155 µM 6.84938038241233 6.94557272313499e-12 yes 3 3.70852687398142e-12 28 15991913 SGTC_976 1348-1067 47.6 µM 6.75816392546362 1.28852683614682e-11 yes 4 6.98756831263176e-12 3 5310671 YGL099W LSG1 SGTC_1991 st073000 8.92 µM 6.16265377147482 5.98929508702824e-10 yes 5 3.5767903234215e-10 32 4301969 YIL048W NEO1 SGTC_1076 itraconazole 331 nM 5.92981640376559 2.45079053368154e-09 yes 6 1.51636793189446e-09 8 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3091 9116372 49.47 µM 5.7639916490614 6.47818308887425e-09 yes 7 4.10737407914652e-09 3 17169793 SGTC_928 2764-0428 58.7 µM 5.37021325807513 5.86756908921895e-08 yes 8 3.9321793152435e-08 23 662578 SGTC_767 0929-0023 86 µM 5.30130921385245 8.49870342843572e-08 yes 9 5.7487580251994e-08 25 1204563 SGTC_1862 st057513 3.81 µM 4.94084622607582 5.48619432526301e-07 yes 10 3.88921188509277e-07 2 5393163 SGTC_730 1436-0052 41.2 µM 4.833221902942 9.34901802610752e-07 yes 11 6.71704492180935e-07 3 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1386 3228-0095 33.8 µM 4.83253559119176 9.3805221705859e-07 yes 12 6.74025010707493e-07 7 870181 SGTC_1594 piperine 70.1 µM 4.7276342860729 1.56054565988491e-06 yes 13 1.1357541743046e-06 5 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2600 tangeritin 87.95 µM 4.5627452173884 3.40134817555619e-06 yes 14 2.52445351864423e-06 20 68077 A bioactive flavone. SGTC_808 0711-0032 135 µM 4.55955582246642 3.45212769555421e-06 yes 15 2.56309647841495e-06 5 4252555 SGTC_723 4182-0001 115 µM 4.46717159983944 5.28089305368195e-06 yes 16 3.96302753183503e-06 19 744821 YLR208W SEC13 SGTC_43 0570-0105 72.5 µM 4.43178635750609 6.20156109950808e-06 yes 17 4.67277962241448e-06 76 1114046 YDL195W SEC31 SGTC_227 fluconazole 33.516 µM 4.38810931722601 7.55000362446512e-06 yes 18 5.71701521005342e-06 68 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1613 st002381 52.1 µM 4.38232354125084 7.74832451016799e-06 yes 19 5.87101301884859e-06 15 551167 SGTC_3131 9127911 49.47 µM 4.35694774090344 8.67830902868125e-06 yes 20 6.59443708292404e-06 18 45595681 SGTC_2005 4024620 188 µM 4.21779282471953 1.59859447984559e-05 yes 21 1.23352664716691e-05 15 236743 SGTC_3129 9127257 49.47 µM 4.15472406061601 2.09601806217564e-05 yes 22 1.62840169270213e-05 19 837894 SGTC_146 3448-8650 53.125 µM 4.09509501744256 2.69869407712003e-05 yes 23 2.10997641053975e-05 129 2891488 YIL048W NEO1 SGTC_969 1313-0238 134 µM 4.05260968138121 3.22462040722049e-05 yes 24 2.5324732726583e-05 23 5212874 SGTC_1400 3771-8998 51.5 µM 4.02312307733296 3.64515902212955e-05 yes 25 2.87157322058227e-05 9 670767 SGTC_920 mycophenolic acid 780.421 nM 3.96643146043185 4.60348068800788e-05 yes 26 3.64783713169167e-05 29 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2115 tiliquinol 12.7705 µM 3.96555998155285 4.6199203311627e-05 yes 27 3.6611917560514e-05 8 71208 A bioactive hydroxyquinoline. SGTC_1334 1486-0610 236 µM 3.96157327169442 4.69583546119146e-05 yes 28 3.72287626107698e-05 17 3742339 SGTC_3031 9088762 49.47 µM 3.90813905342101 5.83399896714083e-05 yes 29 4.65048861304479e-05 20 205253 SGTC_2193 5925765 200 µM 3.90251234296719 5.96793943153394e-05 yes 30 4.75996909756794e-05 7 877370 SGTC_797 k781-0471 270 µM 3.89912278462506 6.0500197562607e-05 yes 31 4.82709060593844e-05 22 23738129 SGTC_3016 9080866 49.47 µM 3.88266690064674 6.46386085733464e-05 yes 32 5.16585275013981e-05 28 17066299 SGTC_2885 9057732 51.95 µM 3.83508963248 7.81551867445712e-05 yes 33 6.27592560810463e-05 14 6471414 SGTC_44 0929-0055 61.211 µM 3.76758307421167 0.00010195397706104 yes 34 8.24178478255712e-05 38 1379590 SGTC_1873 rapamycin 2 nM 3.76251277539178 0.000103992298478371 yes 35 8.41073563549132e-05 75 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2630 antimycin a 100 µM 3.74839422512301 0.000109871646092994 yes 36 8.89851823702236e-05 46 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_380 3970-0968 6 µM 3.7477991291183 0.000110126186543018 yes 37 8.91965133085319e-05 17 2891601 SGTC_1521 st012942 49.4 µM 3.72710111408473 0.000119331724518424 yes 38 9.68473829523505e-05 38 24207259 SGTC_131 0141-0277 33.849 µM 3.72229983924371 0.000121567915935333 yes 39 9.87081964656629e-05 44 1547771 SGTC_3263 9137018 49.47 µM 3.69424069845508 0.000135442590477318 yes 40 0.000110272409623551 24 43844957 SGTC_744 1594-0068 283 µM 3.67016524941814 0.000148516935817237 yes 41 0.000121196858150281 35 668392 SGTC_418 lividomycin a 100 µM 3.60566655472988 0.000189603997092372 yes 42 0.000155676359923769 13 72394 An antibiotic. SGTC_362 0310-0100 9.03 µM 3.55933251509524 0.000225433337777618 yes 43 0.000185899275559793 45 790235 SGTC_1411 3909-8223 150 µM 3.52835147933886 0.000252814299130472 yes 44 0.000209078263242468 17 X1411 SGTC_1319 1306-0155 43.7 µM 3.52547955160297 0.000255503651388187 yes 45 0.000211358405055304 37 3122360 SGTC_3295 9122362 53.5725 µM 3.50589784469177 0.000274563428862446 yes 46 0.000227534920580396 26 4730473 SGTC_3089 9117425 49.47 µM 3.46602167674373 0.000317539521908838 yes 47 0.000264110345494654 46 9401657 SGTC_2557 derrustone 83.84 µM 3.44775025510711 0.000339253024992657 yes 48 0.000282638231435205 51 629853 An antioxidant. SGTC_2827 7993847 71.43 µM 3.40544530333881 0.00039493335559367 yes 49 0.000330281222464839 41 2985692 SGTC_2522 biochanin a 4.94 µM 3.39026761757104 0.000416896995374151 yes 50 0.000349122121861589 23 5280373 A possible chelator. SGTC_3199 9111318 49.47 µM 3.33962309077598 0.000498650271981581 yes 51 0.000419460818689717 44 8548020 SGTC_1714 st033236 13.627 µM 3.3377527311584 0.000501936246131892 yes 52 0.000422294369030066 47 2916566 SGTC_1238 0333-0287 48.8 µM 3.33002382817847 0.000515728595434342 yes 53 0.000434192761756269 47 7226 SGTC_1938 st074717 56.4 µM 3.29814058841657 0.000576414311435084 yes 54 0.000486636952087016 27 17250979 SGTC_1356 1502-0781 85.8 µM 3.28787965417115 0.000597306911070542 yes 55 0.000504724902492094 37 567702 SGTC_1912 st060209 90.8 µM 3.25042559299025 0.00067964873506717 yes 56 0.000576162090731874 63 688787 SGTC_2148 5546263 113.568 µM 3.24267839324916 0.000697937258537847 yes 57 0.000592058959162166 39 792097 SGTC_2808 7946468 45.46 µM 3.21563823693555 0.000765384694177692 yes 58 0.000650773960280896 64 2970879 SGTC_2585 alliin 100 µM 3.21238030501882 0.000773904283350833 yes 59 0.000658199947893818 55 87310 A garlic compound which reacts with lipids. SGTC_2268 7933382 153.85 µM 3.15497385694236 0.000939091839998556 yes 60 0.000802562437845064 62 935025 YOR257W CDC31 SGTC_2706 st078239 82.5 µM 3.14857257604149 0.000959392369432208 yes 61 0.000820349883454394 43 15434492 SGTC_807 1315-0151 48 µM 3.14198852747495 0.000980692255447123 yes 62 0.000839023054184352 56 4011080 SGTC_2448 5185112 27.17 µM 3.13559560605267 0.00100178840705499 no 63 0.000857527580188683 32 5718189 SGTC_656 4090-1979 187 µM 3.09170504480435 0.0011582427208058 no 64 0.000995052425146227 55 22330961 SGTC_2832 7992762 51.95 µM 3.08310576379245 0.00119140221705697 no 65 0.00102426167881087 64 2985177 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.06794127124116 0.00125200271777581 no 66 0.00107769486511488 105 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2567 aureobasidin a 60 nM 3.04727964165725 0.00133911213593135 no 67 0.00115461385062261 152 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1376 2910-0861 41.3 µM 3.04158269928902 0.00136408603367583 no 68 0.00117668953957676 69 1112859 SGTC_3269 9137823 49.47 µM 3.02612682807043 0.00143399878501001 no 69 0.00123854188296658 48 17682936 SGTC_1419 3993-2473 62.6 µM 3.01263177771925 0.00149770057825274 no 70 0.00129496481235039 53 704026 SGTC_963 1269-2853 151 µM 3.00675313508456 0.00152624880717524 no 71 0.00132027051822239 70 3668223 SGTC_1722 st034304 3.6505 µM 3.00390444323894 0.00154026055275989 no 72 0.00133269512325678 88 4036148 YLR033W RSC58 SGTC_794 k038-0031 316 µM 2.99357279123018 0.00159206820987172 no 73 0.0013786586341007 156 6624242 SGTC_1002 4049-0206 172 µM 2.99135172090924 0.00160341103266658 no 74 0.00138872693949644 94 4662749 SGTC_1304 1165-0502 251 µM 2.97456504409376 0.00169154941833709 no 75 0.00146702122713939 110 767425 SGTC_1781 st038725 66.3 µM 2.94379284719863 0.00186465613096756 no 76 0.00162108464536996 165 4270275 YIL048W NEO1 SGTC_1694 st024011 44.9 µM 2.92708714655884 0.00196523543215552 no 77 0.00171076496501339 89 2787533 SGTC_2475 5812728 15.03 µM 2.92150383307922 0.00199993361969549 no 78 0.00174172994574551 69 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2737 bleomycin 30.5 nM 2.90917021387179 0.00207856179414654 no 79 0.00181194748306489 150 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_612 0302-0167 22.4 µM 2.90293007074955 0.00211940262256429 no 80 0.00184844587594054 99 235821 SGTC_1887 st057648 70.8 µM 2.88080182060155 0.00227016249588548 no 81 0.00198332482655433 60 688672 SGTC_1734 st037168 69.4 µM 2.8683267459978 0.00235937516330545 no 82 0.0020632456593743 81 708907 SGTC_221 trifluoperazine 10.304 µM 2.8591095053276 0.00242731583259201 no 83 0.00212416052235866 297 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_834 0312-0008 75.7 µM 2.85586762798926 0.00245162942110186 no 84 0.00214597016110934 100 6385573 YIL048W NEO1 SGTC_1117 retinoic acid 1.10837 µM 2.85421277844023 0.00246412527940887 no 85 0.0021571812164849 59 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2623 humulene 100 µM 2.83459742887205 0.00261669231284487 no 86 0.00229417322886466 68 6187145 An anti-inflammatory. SGTC_2239 6685329 187.64 µM 2.81784170755739 0.00275372038534906 no 87 0.00241738193692615 97 805680 SGTC_70 0141-0289 43.283 µM 2.8015947190316 0.00289273867738759 no 88 0.00254253555459575 320 352408 SGTC_2758 dehydroepiandrosterone 69.35 µM 2.79581920984881 0.00294366164164637 no 89 0.00258841752914467 111 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1140 3229-1848 2.98 µM 2.7954480223075 0.00294696188936222 no 90 0.00259139175945204 43 2849525 SGTC_798 1287-0182 476 µM 2.79398425042653 0.00296000889177041 no 91 0.00260315071114497 83 1649755 SGTC_851 0394-0702 453 µM 2.79195131217012 0.00297821538806175 no 92 0.00261956193638729 60 762646 SGTC_168 3970-0862 530.542 µM 2.78830999585395 0.0030110785410773 no 93 0.00264919086501385 258 3135186 SGTC_1064 honokiol 6.76 µM 2.78208246529219 0.00306804034211718 no 94 0.00270056570300339 82 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1374 2889-5571 141 µM 2.76733883944591 0.00320678398526918 no 95 0.00282579903589051 121 2853281 SGTC_2023 5144124 124 µM 2.7595825393612 0.00328201765711986 no 96 0.00289376325098848 75 2830192 SGTC_2638 epoxomicin 18 µM 2.75957269277432 0.00328211416634579 no 97 0.00289385045996976 84 9915668 A protesome inhibitor. SGTC_86 0417-1630 471.922 µM 2.73392753548933 0.00354230293653903 no 98 0.00312919080319998 257 3634867 SGTC_2011 4012611 177 µM 2.71997604314156 0.00369149752735442 no 99 0.00326433230543041 100 2049887 SGTC_2367 9070478 135.38 µM 2.70602102234353 0.00384634458310537 no 100 0.00340473675630047 110 572802 SGTC_223 busulfan 5 mM 2.70258851419116 0.00388531334177568 no 101 0.00344009313919966 45 2478 A DNA alkylator. SGTC_1970 st070122 35.8 µM 2.69888930552993 0.00392770562956291 no 102 0.00347856564789037 107 102928 SGTC_2968 9090663 33.37 µM 2.6979930481498 0.00393803873694705 no 103 0.00348794487077006 108 25236811 SGTC_2802 7925815 54.55 µM 2.69586871310578 0.00396262788788318 no 104 0.00351026655673881 115 1262923 SGTC_1506 4226-2149 212 µM 2.67688155011332 0.0041885850908168 no 105 0.0037155450516755 112 991114 SGTC_3355 9151058 44.0485 µM 2.66925116516415 0.0042825904753897 no 106 0.00380102895335272 61 17015728 SGTC_3114 9122766 49.47 µM 2.65636561470036 0.0044456275503803 no 107 0.00394939628725702 96 17176985 SGTC_2286 7945697 125 µM 2.65303391299847 0.00448867470142504 no 108 0.00398859278187293 143 1245733 SGTC_338 4055-0136 114 µM 2.64213350955947 0.00463212605936609 no 109 0.00411927865719255 84 2900563 SGTC_1629 st005085 44.9 µM 2.63287118520219 0.00475722018951471 no 110 0.00423332258991451 127 24207091 SGTC_2411 st077133 39.94 µM 2.62897599515834 0.00481072119965156 no 111 0.0042821203050432 133 1403142 YNL221C POP1 SGTC_645 0845-0943 5.41 µM 2.62133626846938 0.00491721413575817 no 112 0.00437929113311416 81 1885106 SGTC_1747 st037496 66.6 µM 2.60563578587743 0.00514268594683052 no 113 0.00458519583936632 104 723305 SGTC_1173 0443-0020 122 µM 2.60068249394066 0.00521570459349135 no 114 0.00465192595037187 137 5331295 SGTC_2831 7999036 19.48 µM 2.58656998782224 0.00542882665120279 no 115 0.00484682409629725 154 2988270 SGTC_2163 5671233 125 µM 2.58491996719317 0.00545424335396924 no 116 0.00487008017707708 122 701023 SGTC_3078 9116413 49.47 µM 2.579783117601 0.00553404914709497 no 117 0.00494311915228438 110 17177322 SGTC_2711 st079103 59.1 µM 2.57777726273687 0.00556549253719474 no 118 0.00497190357590766 68 54693780 SGTC_2244 6635614 200 µM 2.57405864824594 0.00562420485581472 no 119 0.00502566168305175 48 836499 SGTC_2584 androsterone 48.74 µM 2.57219970376883 0.00565376097647418 no 120 0.00505272906860867 279 2754130 A steroid. SGTC_3136 9095672 49.47 µM 2.57191777797205 0.00565825545349772 no 121 0.00505684539991275 104 17217380 SGTC_3011 9081274 71.4286 µM 2.56551484893261 0.00576118909354272 no 122 0.00515114058299065 107 6625322 SGTC_2089 5281248 129.67 µM 2.5653909035768 0.00576319793202176 no 123 0.00515298125003457 116 2737878 SGTC_2983 9022671 12.99 µM 2.55697009075268 0.00590114203631311 no 124 0.00527941478579894 89 6405161 SGTC_2101 5377231 179.231 µM 2.55679841164825 0.00590398456959808 no 125 0.00528202089921511 72 2844213 SGTC_792 4534-1957 155 µM 2.55520415126297 0.00593043918379927 no 126 0.0053062767043745 121 1717904 SGTC_1666 st014829 29 µM 2.55387005334809 0.00595265747992127 no 127 0.00532665035838867 105 3858230 SGTC_1996 st072960 66.8 µM 2.55125984787064 0.00599634186213356 no 128 0.0053667133635223 90 1719405 SGTC_1847 st056231 15 µM 2.53474994031346 0.00627929399278343 no 129 0.00562638101413392 152 5393180 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.51870548858204 0.0065655310327722 no 130 0.00588935658167589 122 688761 SGTC_2738 aclarubicin 5.55 µM 2.50268669546275 0.00686276052475321 no 131 0.00616272997961339 63 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2951 9072950 58.06 µM 2.48691566911457 0.00716693973654953 no 132 0.00644279698951067 123 16488155 SGTC_1252 0493-0875 34.8 µM 2.4837814529612 0.00722878727379197 no 133 0.00649977806716832 135 3960963 SGTC_2245 6637752 200 µM 2.48096811453968 0.00728470328270572 no 134 0.00655130465758675 74 681890 SGTC_803 4488-1585 147 µM 2.47853020554147 0.00733346555130803 no 135 0.00659624701743725 95 747204 SGTC_3187 9109394 49.47 µM 2.46354452411947 0.00763957264932519 no 136 0.0068785403922912 137 17098090 SGTC_22 0964-0034 14.468 µM 2.44357824188479 0.00806486681213726 no 137 0.00727120795569483 164 138402 SGTC_3153 9100258 49.47 µM 2.44302013819 0.00807704797642537 no 138 0.00728246226205902 133 25236848 SGTC_641 4092-0595 30 µM 2.4385780763984 0.00817457828124918 no 139 0.00737258651592549 113 786260 SGTC_667 1498-1044 59 µM 2.43072893442276 0.00834944618150274 no 140 0.00753424157053845 131 6739982 SGTC_2324 6149169 200 µM 2.41183566092788 0.00878389170011418 no 141 0.00793621703058742 107 2888231 SGTC_693 4161-2696 114 µM 2.40233858152765 0.00900966578827985 no 142 0.00814531123253271 74 805759 SGTC_481 bay k-8644 50 µM 2.39551614218756 0.00917497758228112 no 143 0.0082984917082343 133 2303 A calcium channel antagonist. SGTC_2525 harmine 47.85 µM 2.39423313329351 0.00920636054860511 no 144 0.00832757933315175 85 5280953 A monoamine oxidase inhibitor SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.38588997348673 0.00941273932308512 no 145 0.00851892380421674 104 2724278 An inhibitor of dopamine biosynthesis. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.36343634414368 0.00998838169113229 no 146 0.00905316846391356 95 61125 An anti-inflammatory. SGTC_1947 st076332 61.6 µM 2.3567132628453 0.0101666145870273 no 147 0.00921873868300866 115 24208416 SGTC_2156 5649887 115 µM 2.35668816381147 0.0101672851421937 no 148 0.00921936173313311 140 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_725 1497-0963 19 µM 2.35023801308163 0.0103408938916684 no 149 0.00938070494697301 111 3549977 SGTC_2814 7977482 42.97 µM 2.34943812220909 0.0103626024252365 no 150 0.00940088445074031 200 6456762 SGTC_2866 9034245 58.44 µM 2.33421829579801 0.0107832946042535 no 151 0.0097921471861329 99 6462273 SGTC_583 1488-1091 88.9 µM 2.31777709552816 0.011254378370948 no 152 0.0102307192646622 163 4303273 SGTC_1443 4112-3303 14 µM 2.31565874939346 0.0113163568812564 no 153 0.0102884541884454 130 704433 SGTC_2160 5660466 132.927 µM 2.31447850762859 0.01135101686813 no 154 0.0103207444254437 133 2859134 SGTC_2332 7982454 138.89 µM 2.31349949110119 0.0113798374628461 no 155 0.0103475963533287 205 2981748 SGTC_1987 st072290 61.9 µM 2.31210725448495 0.011420932051067 no 156 0.0103858867416421 127 54697379 SGTC_2826 7992541 19.48 µM 2.30330415129292 0.0116837697036781 no 157 0.0106308681201817 151 2985066 SGTC_2629 bisabolol 100 µM 2.29793415658889 0.0118466690289499 no 158 0.010782768449917 166 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.28050765156175 0.0123889502713527 no 159 0.0112887987517342 149 75037 A free radical scavenger. SGTC_2523 spermine 47.74 µM 2.2664951632074 0.0128404621425642 no 160 0.0117105414818382 146 1103 A DNA binding polyamine. SGTC_2176 5809774 33.9695 µM 2.26107396012604 0.0130189253438223 no 161 0.0118773387792892 132 2870539 SGTC_318 1488-0629 67.2 µM 2.25946424409925 0.0130723275424678 no 162 0.011927261027782 124 3662576 SGTC_1926 methyl fluorone black 53.6 µM 2.25904285834046 0.0130863382110188 no 163 0.0119403595170253 193 72721 Reacts with homocysteine. SGTC_1289 0976-0073 69.1 µM 2.25838099774236 0.0131083706375199 no 164 0.0119609581911655 136 3391136 SGTC_3235 9132602 49.47 µM 2.25771835793538 0.0131304611112187 no 165 0.0119816119831341 166 4912240 SGTC_269 exalamide 29 µM 2.24801914288968 0.0134575050600463 no 166 0.0122874846445596 116 3316 A derivative of salicylamide. SGTC_738 1315-0003 72.4 µM 2.24608964005736 0.0135233972766033 no 167 0.0123491333989391 164 6251474 SGTC_274 sirtinol 40.1 µM 2.24500935792748 0.0135604102083668 no 168 0.0123837659113021 150 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1269 0831-0796 3.05 µM 2.2404382955865 0.0137179945508856 no 169 0.0125312412269494 147 927758 SGTC_59 0330-0160 1.33 µM 2.23753887889742 0.0138187667878705 no 170 0.0126255706144628 337 4293482 SGTC_2365 9042475 200 µM 2.22512792218462 0.0142573702876976 no 171 0.0130363258888887 186 6464479 SGTC_2199 6590217 200 µM 2.21901234471641 0.0144778699823719 no 172 0.0132429423525902 76 703109 SGTC_1434 4073-0095 163 µM 2.21621206624232 0.0145798110631494 no 173 0.013338490945673 133 24133745 SGTC_3293 9120939 62.045 µM 2.21575336063663 0.014596568483237 no 174 0.0133541991073654 151 934087 SGTC_14 0354-0009 295 µM 2.21500994583986 0.0146237620884968 no 175 0.0133796909316352 162 1713507 SGTC_2235 salicylic acid 500 µM 2.20398433832276 0.0150322174163737 no 176 0.0137627227724068 98 338 A COX inhibitor and kinase inhibitor. SGTC_184 1494-0393 24.714 µM 2.19831443797825 0.015246056208907 no 177 0.0139633531150177 224 3090647 SGTC_2189 6047310 154.431 µM 2.19750529617031 0.0152767848196869 no 178 0.0139921893244399 139 711535 SGTC_632 0781-2353 4.65 µM 2.18456350420133 0.0157755492889821 no 179 0.0144604331523473 214 6811515 YHR007C ERG11 SGTC_799 1310-0557 151 µM 2.18289052046614 0.0158410328922374 no 180 0.014521936650461 181 5354492 SGTC_1362 1611-0397 101 µM 2.18023475821037 0.0159454629123308 no 181 0.0146200321796312 167 27816 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.17342815546044 0.0162158109305452 no 182 0.0148740538299206 220 6708561 SGTC_2380 9035439 200 µM 2.17275512501923 0.0162427547797656 no 183 0.0148993762066197 197 6462575 SGTC_648 0375-0473 33.3 µM 2.16393636810282 0.0165993600580142 no 184 0.0152346166525737 185 1713139 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.16360586792001 0.0166128537811272 no 185 0.0152473054050646 186 5355888 SGTC_1414 3917-0015 5.4 µM 2.16079718492392 0.0167279065342531 no 186 0.0153555048159972 139 6618702 SGTC_575 k072-0246 11.9 µM 2.15857571090295 0.0168193874534759 no 187 0.0154415494078287 185 6796779 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.15847838813861 0.0168234049964953 no 188 0.0154453284662308 235 688664 SGTC_2344 7990960 76.95 µM 2.1573042850206 0.0168719374021681 no 189 0.0154909816796852 176 140813 SGTC_343 4130-2827 29.8 µM 2.14363712811369 0.0174457442035243 no 190 0.0160309867200884 204 1118244 SGTC_1052 3253-3998 198 µM 2.14116680628942 0.0175512177548772 no 191 0.0161302944090234 217 5450317 SGTC_3245 9134821 49.47 µM 2.14040912340144 0.0175836768807762 no 192 0.0161608589315508 188 17014901 SGTC_1557 sumaresinolic acid 42.3 µM 2.13970347019926 0.0176139531238369 no 193 0.0161893692184534 184 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_961 1252-1571 372 µM 2.13693912297404 0.0177329871140987 no 194 0.0163014716949524 203 6813498 SGTC_572 0960-0087 17.7 µM 2.136449014926 0.0177541628528157 no 195 0.0163214162585205 239 6796365 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.10508368015596 0.0191549512291488 no 196 0.0176420122867829 232 442882 SGTC_672 1441-0018 53.7 µM 2.10379100606458 0.0192146437698218 no 197 0.0176983408491416 171 251141 SGTC_316 k060-0003 58.6 µM 2.10101472243606 0.0193433804131725 no 198 0.0178198369476764 170 6152314 SGTC_1755 st041960 45.185 µM 2.09798685365435 0.0194846179082318 no 199 0.017953153349994 189 2257073 SGTC_1445 4239-0156 97.7 µM 2.09695542533563 0.0195329293483254 no 200 0.0179987606989477 220 4008346 SGTC_2572 astragaloside iv 100 µM 2.09553510927286 0.0195996225195447 no 201 0.0180617254049352 213 45006101 An anti-inflammatory agent. SGTC_1612 st002233 45.4 µM 2.08911903737853 0.0199033140729483 no 202 0.0183485045312286 179 1035021 SGTC_665 3914-0008 307 µM 2.08787786270229 0.01996252113572 no 203 0.0184044267807379 203 1069549 SGTC_2396 5342950 42.78 µM 2.07685679606503 0.0204948374637764 no 204 0.0189073891593085 256 1886677 SGTC_3240 9133527 49.47 µM 2.07063411075505 0.0208006704670374 no 205 0.0191965009705406 167 17617455 SGTC_2513 baicalein 25.65 µM 2.06783943021498 0.0209392759573933 no 206 0.0193275622781469 195 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2807 7945238 51.95 µM 2.05657228736566 0.0215060382521639 no 207 0.0198636931131432 235 17148797 SGTC_1564 D-Arginine 115 µM 2.05438466880105 0.021617570380818 no 208 0.0199692378638889 217 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_879 0831-1030 162 µM 2.04341605758312 0.0221841826169551 no 209 0.0205056346157181 276 1549252 SGTC_377 3970-0964 33.1 µM 2.03907203359223 0.0224120235755258 no 210 0.0207214194371777 312 16481235 SGTC_1166 k206-0078 225 µM 2.03675196254825 0.0225345160503516 no 211 0.0208374522017724 237 5404595 SGTC_3303 9125618 40.5795 µM 2.02639222741802 0.0230883869347975 no 212 0.0213623034111591 282 22695467 SGTC_1620 st003704 16.5 µM 2.02310370801409 0.0232665831531247 no 213 0.0215312281714401 173 2834414 SGTC_382 3229-0966 23.2 µM 2.01379920514183 0.0237770519391799 no 214 0.0220153096111361 223 5722370 SGTC_3028 9087778 49.47 µM 2.00807900889665 0.0240955258423683 no 215 0.0223174482445239 188 17217395 SGTC_36 0335-0881 14.2 µM 2.00038954267017 0.0245292794691928 no 216 0.022729108354101 330 23828853 SGTC_941 3237-0776 460 µM 1.99928784367351 0.0245919584680901 no 217 0.0227886093487231 200 760008 SGTC_1806 st050005 60.3 µM 1.99819095934692 0.0246544970117762 no 218 0.0228479806537238 224 5194765 SGTC_565 1418-0001 44.5 µM 1.99158833169586 0.025033769332101 no 219 0.0232081223331017 255 2862145 SGTC_1065 prochlorperazine maleate 2.48 µM 1.98293632502817 0.0255381562991203 no 220 0.0236872712509671 242 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1637 st007924 17.4 µM 1.98213066309287 0.0255855541429779 no 221 0.0237323092356564 223 683336 SGTC_1387 3342-1166 1.8 µM 1.97591023777881 0.0259539928432032 no 222 0.024082472235232 138 3418228 SGTC_391 gliotoxin 8.33 µM 1.96728756729625 0.0264720494744116 no 223 0.0245750337772919 268 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2661 dactinomycin 12.96 µM 1.96271880993805 0.0267500280056837 no 224 0.0248394281233514 228 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3188 9110789 49.47 µM 1.95119668372189 0.0274619150024904 no 225 0.0255168266684266 234 849217 SGTC_3099 9120367 49.47 µM 1.95107363082701 0.0274696021759816 no 226 0.0255241437501018 204 24824940 SGTC_2084 5306078 60.6385 µM 1.94047725157118 0.028138324589981 no 227 0.0261608580902666 239 679340 SGTC_1194 1488-0194 225 µM 1.9391304926142 0.0282242794046212 no 228 0.0262427252849134 266 1391452 SGTC_1965 Pectolinarigenin 58.4 µM 1.93687853093594 0.0283684956329189 no 229 0.0263800966946543 210 5320438 An anti-inflammatory. SGTC_1116 jasmonic acid  1.58368 µM 1.93506275033687 0.0284852247913472 no 230 0.0264912979221046 235 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_626 0214-0009 33 µM 1.92878779969377 0.0288916964868056 no 231 0.0268786055237955 235 3437874 SGTC_863 0466-0191 129 µM 1.92817604170535 0.0289315809074244 no 232 0.0269166165777321 296 765160 YPR165W RHO1 SGTC_708 3448-5400 146 µM 1.92671930483646 0.0290267391676131 no 233 0.0270073103446026 284 3462195 SGTC_3058 9093861 49.47 µM 1.92522290813314 0.0291247587756514 no 234 0.0271007386791964 252 17217477 SGTC_54 0159-0055 9 µM 1.92436094083112 0.0291813455918461 no 235 0.0271546783875864 233 3319099 SGTC_2815 7968870 71.43 µM 1.92368461170771 0.029225809467054 no 236 0.0271970640232363 287 2977326 YHR190W ERG9 SGTC_658 3253-0951 102 µM 1.92275484038587 0.0292870272255548 no 237 0.0272554229989365 328 1184878 SGTC_329 k048-0121 21.3 µM 1.92260813049652 0.0292966965804425 no 238 0.0272646410765761 225 6832902 SGTC_1942 st076330 65.2 µM 1.92118440419964 0.0293906693060323 no 239 0.0273542318132526 251 24208414 SGTC_892 0929-0076 29 µM 1.91997587369431 0.0294706343553703 no 240 0.0274304734736366 314 5751038 SGTC_2214 7179297 48.276 µM 1.91875007468579 0.0295519264388062 no 241 0.0275079854674825 166 769744 SGTC_1221 2958-7315 257 µM 1.91461870356006 0.0298272810937853 no 242 0.0277705740459934 250 4562705 SGTC_2003 4023581 200 µM 1.90845587710972 0.0302419844198519 no 243 0.0281661603788269 261 16641307 SGTC_2051 5263410 176 µM 1.90373396982398 0.0305629504705172 no 244 0.0284724199662883 248 227584 SGTC_3356 9151811 4.48 µM 1.90115352119348 0.0307395423728061 no 245 0.0286409534829047 250 1859254 YPR165W RHO1 SGTC_2111 5486399 200 µM 1.90101622243065 0.0307489619767721 no 246 0.0286499438971507 294 689674 SGTC_2196 6573537 42.6665 µM 1.90055009219975 0.0307809594271327 no 247 0.0286804839260305 197 2903087 SGTC_3044 9093193 49.47 µM 1.89964118176899 0.030843430748739 no 248 0.0287401119935712 283 25236277 SGTC_130 0136-0219 337.655 µM 1.89644022541402 0.031064275400299 no 249 0.0289509285230547 249 234244 SGTC_2690 usnic acid 100 µM 1.89304300757698 0.0313000902734063 no 250 0.029176075159634 283 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2741 miltefosine 3.04 µM 1.88305560547424 0.0320019438789598 no 251 0.0298464163501138 197 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2102 5377816 72.7585 µM 1.88112081738803 0.0321394005850459 no 252 0.0299777428947645 264 1379702 SGTC_3183 9108214 49.47 µM 1.87969022379862 0.0322413500056592 no 253 0.0300751543639067 111 4974831 SGTC_2109 5483026 200 µM 1.87807978248634 0.0323564352515248 no 254 0.0301851258197879 296 759335 SGTC_918 glabranin 770.725 nM 1.87688154066487 0.0324422836847626 no 255 0.0302671656950844 276 124049 Also referred to as licorice root. SGTC_265 mycophenolic acid 32.932 µM 1.87554400086687 0.0325383340343697 no 256 0.0303589610510654 273 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1958 st076513 41.9 µM 1.87397280872351 0.0326514627241955 no 257 0.0304670865007809 288 732122 YGL099W LSG1 SGTC_3211 9128781 49.47 µM 1.87236852020556 0.0327673088938976 no 258 0.0305778185390406 315 17194361 SGTC_3093 9117344 49.47 µM 1.86124175649395 0.0335801336029698 no 259 0.0313550220255578 239 24824913 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.85925152481036 0.0337272580096599 no 260 0.0314957472780696 283 115019 SGTC_2507 purpurin 79.67 µM 1.8570648056718 0.0338895185166486 no 261 0.0316509673084616 287 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2416 tofa 880 nM 1.85400848128769 0.0341173815047494 no 262 0.0318689733097573 293 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1840 st055363 71 µM 1.84889511255205 0.0345014223222298 no 263 0.0322364797869121 228 676033 SGTC_1565 sinapyl alcohol 95.1 µM 1.84298418394881 0.0349497822922649 no 264 0.0326656598684078 279 5280507 A phenol propionate derived from cinnamic acid. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.84205291343735 0.0350208558736037 no 265 0.0327337051947771 314 23665772 A membrane-active detergent. SGTC_3299 9121982 43.1275 µM 1.84150167523317 0.0350629816475392 no 266 0.0327740376596386 277 17594604 YPL160W CDC60 SGTC_731 3966-0296 387 µM 1.83809422909553 0.0353243034557004 no 267 0.0330242607107641 267 660956 SGTC_1876 myriocin 605 nM 1.83735598801597 0.0353811302150032 no 268 0.0330786798094373 239 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_140 0062-0056 502.533 µM 1.83422184230837 0.0356232191972538 no 269 0.0333105352046188 308 3758964 SGTC_1737 st035557 69.7 µM 1.83079864680668 0.0358891847357575 no 270 0.0335653012031382 217 5716916 SGTC_370 0180-0345 38.7 µM 1.82523871360253 0.0363246295743954 no 271 0.0339825070380273 234 3989527 SGTC_580 1123-0028 41 µM 1.80908436450045 0.0376143997978445 no 272 0.0352189488843005 357 1677248 YPR107C YTH1 SGTC_24 0417-1663 219 µM 1.80743774915975 0.037747940381439 no 273 0.0353470262946929 261 4329390 SGTC_2750 bromebric acid 70.15 µM 1.8065897375846 0.0378168649791753 no 274 0.0354131353998731 333 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_548 1436-0017 110 µM 1.80656099686229 0.0378192027629396 no 275 0.035415377738164 334 9677137 SGTC_129 0088-0017 176.636 µM 1.80319854324435 0.038093521443144 no 276 0.0356785195954389 318 182446 SGTC_2318 6029776 164 µM 1.80313481881438 0.0380987358953595 no 277 0.0356835220286302 307 818325 SGTC_1902 st060212 70.5 µM 1.80208435396893 0.0381847774235332 no 278 0.0357660674715436 277 688944 SGTC_2928 9011484 9.79 µM 1.80133633791349 0.038246142506244 no 279 0.0358249418429809 263 2994751 SGTC_1808 st050063 61.5 µM 1.79763918093178 0.0385506286240362 no 280 0.0361171025634208 264 4011993 SGTC_302 1094-0063 18.9 µM 1.77871720213551 0.0401400511884657 no 281 0.037643068748737 226 5440289 SGTC_1481 3346-2004 36 µM 1.77702325229017 0.0402849001441033 no 282 0.0377822070929504 294 2770522 SGTC_552 k242-0005 476 µM 1.7583484480398 0.0419100788774647 no 283 0.0393441194761609 252 4088318 SGTC_1136 pergolide 1.05886 µM 1.75182857388484 0.0424898215668669 no 284 0.0399016446538908 411 47811 A dopamine receptor agonist. SGTC_1969 st069479 40.1 µM 1.75093712070312 0.0425695905911673 no 285 0.0399783708750152 261 3895485 SGTC_1338 1486-1223 76 µM 1.74882309218339 0.0427592422513451 no 286 0.0401608019288688 311 3444526 SGTC_1283 0922-0125 16.4 µM 1.74842422404456 0.0427951015915436 no 287 0.0401952981579043 320 3360884 SGTC_2654 protoveratrine a 100 µM 1.74687543156796 0.0429345727813668 no 288 0.0403294741847064 271 5702278 A heart drug and vasodilator. SGTC_3193 9111931 49.47 µM 1.74307703357257 0.0432781797830148 no 289 0.0406600798582777 304 17087244 SGTC_445 e6 berbamine 66 µM 1.7368246266662 0.043848611959558 no 290 0.0412090653954301 460 6610268 A calcium/calmodulin antagonist. SGTC_305 1682-2595 20.8 µM 1.73474337116318 0.0440398331904102 no 291 0.0413931352596659 300 226033 SGTC_581 0958-0271 211 µM 1.72977055919327 0.0444994476624598 no 292 0.0418356382310275 401 4591145 SGTC_1432 4049-0298 68.4 µM 1.72902450972651 0.0445687338180065 no 293 0.0419023542777285 274 741646 SGTC_1782 st039423 80.636 µM 1.72805524383314 0.0446588800090994 no 294 0.0419891602536063 306 2068169 SGTC_1062 mesoridazine 14.2 µM 1.72662239775172 0.0447924102352446 no 295 0.0421177503692496 325 4078 A neuroleptic. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.72517818485796 0.0449273248913383 no 296 0.0422476829196754 319 390807 SGTC_691 1548-0686 185 µM 1.72155349872126 0.0452673748434818 no 297 0.0425752165092708 355 46495133 SGTC_924 2046-0044 21.3 µM 1.71989632987232 0.0454235303619999 no 298 0.0427256438961353 314 3623589 SGTC_3344 9148862 3.898 µM 1.71622639105753 0.0457708919578437 no 299 0.0430603073501931 293 4905352 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.71226148901719 0.0461485678743348 no 300 0.0434242451674487 286 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1484 3473-2379 286 µM 1.70814482943494 0.0465433437300424 no 301 0.0438047362479441 363 671917 SGTC_1982 st072467 71.9 µM 1.70757639383134 0.0465980674078586 no 302 0.0438574858163668 383 3163533 SGTC_2142 5622915 118.518 µM 1.70680502902213 0.0466724097755006 no 303 0.0439291486946594 271 5322196 SGTC_1085 doxorubicin 7.67 µM 1.70287364993058 0.0470527867620739 no 304 0.0442958580786107 369 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_214 4373-3496 70 µM 1.69994775035314 0.0473374896514756 no 305 0.0445703770078708 474 3779166 SGTC_467 ro 31-8220 72.8 µM 1.69852232729533 0.0474766888039044 no 306 0.0447046111627312 392 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1891 st059073 26.2 µM 1.69835612979577 0.0474929400831012 no 307 0.0447202833934141 346 688754 SGTC_2107 5363541 170.161 µM 1.69405014268079 0.0479155478115087 no 308 0.0451278775898487 327 244052 SGTC_1504 k297-0033 30 µM 1.69101794337593 0.0482149428955218 no 309 0.0454166878450615 257 4388117 SGTC_2561 acetosyringone 100 µM 1.69075721489742 0.0482407565844335 no 310 0.045441590903456 391 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2781 5567276 71.43 µM 1.69031892288208 0.0482841750466236 no 311 0.0454834784008316 345 2853274 SGTC_981 1488-1094 54.9 µM 1.68541002440477 0.0487726033041546 no 312 0.0459547454588016 269 3449522 SGTC_2210 7115885 190.385 µM 1.68191295013388 0.0491229596549233 no 313 0.0462928605605191 319 2927039 SGTC_1614 st002383 48.6 µM 1.6725284384149 0.0500730932724324 no 314 0.0472100824452705 337 1947235 SGTC_455 paf C-16 10 µM 1.67081536363899 0.050248104498768 no 315 0.0473790764709464 313 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2096 5468907 200 µM 1.67014085314856 0.0503171475066414 no 316 0.0474457494776455 322 759785 SGTC_294 k038-0071 157 µM 1.66746654935484 0.0505916341237553 no 317 0.0477108352554556 379 24152826 SGTC_1236 0330-0013 258 µM 1.66254075701198 0.0511003308008156 no 318 0.0482021992068394 294 4617066 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.65613849427392 0.0517675796942238 no 319 0.0488468876875324 339 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1980 st071811 45.7 µM 1.65344935855723 0.0520499007557314 no 320 0.0491197222592699 326 4974850 SGTC_1867 st057372 64 µM 1.639197476946 0.0535666206513345 no 321 0.0505860695684167 340 688837 SGTC_2063 5246145 200 µM 1.6369222820918 0.0538119614259053 no 322 0.0508233547518392 375 711240 SGTC_1664 st014217 9.02 µM 1.63550331576394 0.053965422604988 no 323 0.0509717900845157 357 3982782 SGTC_1458 k015-0034 6.33 µM 1.63050603719385 0.0545086383949843 no 324 0.0514972951457835 338 3598957 SGTC_490 phenamil 164 µM 1.62504487056888 0.0551072155819641 no 325 0.0520764991567998 248 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3350 9150499 3.57 µM 1.61951784865592 0.0557182861369601 no 326 0.0526679446656215 421 4910996 YPR165W RHO1 SGTC_1244 0416-0015 52.5 µM 1.61928413402821 0.0557442431196693 no 327 0.0526930714030785 369 96201 SGTC_3202 9113761 49.47 µM 1.61485364466886 0.0562381125543332 no 328 0.0531711964070848 451 4798415 SGTC_1219 1469-0211 33.1 µM 1.61319484286277 0.0564239053761735 no 329 0.0533510917652374 320 6822282 SGTC_513 4245-1575 41.7 µM 1.60736858447531 0.0570803068513799 no 330 0.0539867686608684 530 719745 SGTC_2472 5377652 49.4 µM 1.60302472310351 0.0575735978336541 no 331 0.0544645979372205 424 1610903 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.60171721592059 0.0577227336681572 no 332 0.0546090781996502 347 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1524 corynanthine 62.1 µM 1.59656612280495 0.0583132310403603 no 333 0.0551812277310251 360 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_235 0330-0087 5 mM 1.59621835299528 0.058353268114344 no 334 0.055220025710909 403 46494818 YHR062C RPP1 SGTC_2168 5727979 200 µM 1.59231367762967 0.0588042781730622 no 335 0.0556571205996366 341 695210 SGTC_3261 9137475 49.47 µM 1.59139263387029 0.0589110611838328 no 336 0.0557606205190727 183 17027690 SGTC_1606 st000094 49.2 µM 1.59128934126103 0.0589230460967847 no 337 0.0557722372249666 372 1242210 SGTC_2643 anethole 100 µM 1.58905495802896 0.0591827673661113 no 338 0.0560239927712289 393 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1545 lovastatin 49.4 µM 1.57276236801292 0.0611038242043166 no 339 0.0578869261908636 430 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_505 gw-5074 63.9 µM 1.56250707113605 0.0623377982368166 no 340 0.059084290685686 412 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2313 7726885 200 µM 1.56239833228434 0.0623509856536228 no 341 0.0590970898694021 401 726423 SGTC_2232 chlorophetanol 41.5365 µM 1.56069906471925 0.0625573488459728 no 342 0.0592973860279705 528 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2431 5490079 200 µM 1.56049668637999 0.0625819616052036 no 343 0.0593212762084728 395 5722345 SGTC_3086 9117350 49.47 µM 1.56043584392001 0.0625893625922053 no 344 0.0593284599610161 272 2679265 SGTC_633 0437-0093 97.7 µM 1.55958070406241 0.0626934555503596 no 345 0.0594294996737268 363 2831118 SGTC_1625 st003711 30.1 µM 1.55726621016541 0.0629758670001626 no 346 0.0597036471711885 375 24207034 YER133W GLC7 SGTC_2856 9022925 19.48 µM 1.55093516121991 0.063753436774701 no 347 0.0604586115526874 405 4944862 SGTC_1112 tnp00069 1.16933 µM 1.54952688873558 0.0639274098601391 no 348 0.0606275564332395 450 145826 SGTC_3220 9131269 49.47 µM 1.54920625377612 0.0639670715387068 no 349 0.0606660733046908 346 17722206 SGTC_119 0121-0043 24.815 µM 1.54690039061464 0.0642528644322516 no 350 0.0609436334337061 596 1092378 SGTC_2480 5767542 37.17 µM 1.54505248364567 0.0644826129259762 no 351 0.0611667845072583 370 2867358 SGTC_675 1309-0189 238 µM 1.5444372261119 0.0645592487651903 no 352 0.0612412238118275 378 4246530 SGTC_69 0096-0274 206.684 µM 1.54357152937422 0.0646671988379631 no 353 0.0613460833172475 470 6741392 SGTC_570 0987-0065 62.6 µM 1.54121077731748 0.0649622907564914 no 354 0.0616327476810849 292 3104428 SGTC_1437 4092-1038 11.6 µM 1.53859724258176 0.0652901982801785 no 355 0.0619513260707394 408 3977136 SGTC_2845 9003024 42.97 µM 1.53145587712353 0.0661927395994346 no 356 0.0628283816431524 430 2990173 SGTC_2798 7813637 45.45 µM 1.53060700656984 0.0663006612142149 no 357 0.0629332745164171 434 956368 SGTC_1145 3546-0597 10.2 µM 1.53036504380685 0.0663314482229013 no 358 0.0629631982393756 437 875334 SGTC_1268 0828-0275 2.46 µM 1.5276307037725 0.0666801317616721 no 359 0.0633021270260697 407 745337 SGTC_1660 st012960 28.1 µM 1.52669003257937 0.0668004137078365 no 360 0.0634190535546334 430 24207266 SGTC_2184 6075246 200 µM 1.52549515082023 0.0669534430844854 no 361 0.0635678210658226 395 2267320 SGTC_2958 9077254 16.72 µM 1.52485410046975 0.0670356545615407 no 362 0.0636477462239889 375 16457351 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.51908419061456 0.0677791342023969 no 363 0.0643706527946016 467 6708784 An antioxidant flavonoid SGTC_1673 st016611 27.3 µM 1.51429412558748 0.0684011813563738 no 364 0.0649756289076675 440 5226799 SGTC_1031 k035-0009 16 µM 1.50719775722894 0.0693308140580164 no 365 0.0658799874877601 457 5180959 SGTC_573 3702-0553 84.7 µM 1.50289147105948 0.0698996693147701 no 366 0.0664335163706615 405 1222756 SGTC_256 clotrimazole 625 nM 1.49400137599103 0.0710853938203515 no 367 0.0675876298155113 425 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_424 splitomicin 100 mM 1.4938635914815 0.0711038917558802 no 368 0.0676056381607412 414 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_523 1934-0222 13.7 µM 1.48819418660242 0.0718682339367298 no 369 0.0683498449677093 442 1361595 SGTC_1526 st051518 75 µM 1.48585307532787 0.0721856917115728 no 370 0.068658993887896 379 673993 SGTC_1250 0485-0349 40.2 µM 1.48542069903293 0.072244439910145 no 371 0.0687162079241938 441 6842794 YDL195W SEC31 SGTC_577 r071-0003 38.6 µM 1.48453914956809 0.0723643320512066 no 372 0.0688329725230768 572 4568517 YMR134W ERG29 SGTC_276 colchicine 750 µM 1.48170721185378 0.0727505117428982 no 373 0.069209108659994 455 2833 A microtubule depolymerizer. SGTC_1562 morin hydrate 59.1 µM 1.48167990583501 0.0727542430184392 no 374 0.0692127431206016 421 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_855 0428-0020 25 µM 1.48065653682611 0.0728941886288509 no 375 0.0693490606967567 384 6812414 SGTC_277 nystatin 15.5 µM 1.48055895859975 0.0729075431953301 no 376 0.0693620693685219 449 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_486 niguldipine 82 µM 1.47568943007995 0.073576368976882 no 377 0.0700136423876105 367 1236 A calcium channel blocker. SGTC_2025 5147754 141 µM 1.47458671488756 0.0737284754525953 no 378 0.0701618443766446 394 315777 YLR208W SEC13 SGTC_2461 5755302 26.15 µM 1.4705435896711 0.0742882334371104 no 379 0.0707072945386892 477 2788904 SGTC_2083 5306046 65.942 µM 1.46932413737757 0.0744576982203775 no 380 0.0708724464713686 471 539837 SGTC_1134 3477-0009 42.5 µM 1.46822137573622 0.0746112007134585 no 381 0.0710220498598893 488 3973534 SGTC_3351 9150312 21.596 µM 1.46599073199381 0.0749224406771464 no 382 0.0713254058848461 454 4904905 SGTC_1086 cerivastatin 2.18 µM 1.46586700961169 0.074939732509002 no 383 0.0713422605577517 410 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_336 4111-0029 111 µM 1.46531727903827 0.0750166014094284 no 384 0.0714171872055946 364 3131175 SGTC_332 4112-0506 40.9 µM 1.46131693171037 0.0755777826105117 no 385 0.0719642426841823 438 2790355 SGTC_956 1185-0240 191 µM 1.45502827966078 0.0764664329860597 no 386 0.072830716313259 430 1416193 SGTC_2059 5238311 157 µM 1.4530150895975 0.0767525904391377 no 387 0.0731097822159725 431 703021 SGTC_2473 5854593 8.94 µM 1.44790855434313 0.077482091663207 no 388 0.0738213134664043 406 2872951 SGTC_1850 st056238 17 µM 1.446356782636 0.0777048120723961 no 389 0.0740385784411658 507 5393177 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.4453888206089 0.0778439862247016 no 390 0.0741743508865183 511 676296 Flavone; oxidizing agent. SGTC_2339 9000433 200 µM 1.44516768159738 0.0778758082530968 no 391 0.0742053959053879 410 2988954 SGTC_150 3970-0969 77.2 µM 1.43726264378806 0.0790198426766939 no 392 0.0753216895505924 549 6615640 SGTC_345 1362-0200 395 µM 1.437133666609 0.0790386135092082 no 393 0.0753400083474072 415 1419823 SGTC_3179 9107801 49.47 µM 1.43620565830318 0.0791737717721153 no 394 0.0754719147142056 446 4818259 SGTC_181 1447-1644 8.07 µM 1.43550491318771 0.0792759465676383 no 395 0.0755716346392809 452 534600 SGTC_2688 kanamycin b 96.69 µM 1.43517589388344 0.0793239548976812 no 396 0.0756184905357488 992 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1616 st002734 56.1 µM 1.43511960870427 0.0793321698643517 no 397 0.0756265083687507 475 4026101 SGTC_2767 sibutramine 71.45 µM 1.43388563894413 0.079512432791038 no 398 0.0758024503596649 467 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1189 1431-2119 7.28 µM 1.43099280305205 0.0799362439750445 no 399 0.0762161388906874 493 3107275 SGTC_1133 3473-0247 50 µM 1.42889424224505 0.080244758388748 no 400 0.0765173162962226 495 711311 SGTC_2531 methyl deoxycholate 70.07 µM 1.42542798687613 0.0807563103623192 no 401 0.0770167614092487 448 16667744 Haematoxylin. SGTC_124 0136-0217 7.121 µM 1.42357140750118 0.0810313161589637 no 402 0.07728528880701 556 3976905 SGTC_843 0310-0051 143 µM 1.42216119574284 0.0812406756552561 no 403 0.0774897304255598 457 2065037 SGTC_2483 5729050 27.16 µM 1.42055215998809 0.0814800506605613 no 404 0.0777234973436642 573 2865180 SGTC_3036 9090181 49.47 µM 1.41978263944382 0.0815947194905917 no 405 0.0778354853099241 428 25236586 SGTC_518 1021-0119 62.6 µM 1.41911485762043 0.0816943264679214 no 406 0.0779327664968514 473 1097762 SGTC_126 0417-1624 672.48 µM 1.41886242922304 0.0817320027952911 no 407 0.0779695638058776 584 41912 YDL195W SEC31 SGTC_1738 st035555 74 µM 1.41613361189065 0.0821401303053816 no 408 0.0783681943540648 475 5331140 SGTC_2888 9058547 12.99 µM 1.41586111652224 0.0821809694261587 no 409 0.0784080856765824 384 16476514 SGTC_597 k018-0003 82.8 µM 1.41546255316491 0.0822407300094557 no 410 0.0784664601522172 502 6786234 SGTC_1094 duloxetine 25.4 µM 1.40995803984134 0.0830694272782655 no 411 0.0792760365717066 478 60834 A selective serotonin reuptake inhibitor. SGTC_2939 9044578 71.43 µM 1.40762032626371 0.0834232608418592 no 412 0.0796217626695997 457 2653634 SGTC_2743 auranofin 4.32 µM 1.40440488339594 0.0839117954919422 no 413 0.0800991587687365 451 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1363 1636-0063 10.4 µM 1.40414344608068 0.0839516109190468 no 414 0.0801380692263307 507 6072185 SGTC_3314 9135860 59.4275 µM 1.40280285751799 0.0841559978953589 no 415 0.0803378173353575 475 25252478 SGTC_2269 7935389 174.42 µM 1.40205840651367 0.0842696585503726 no 416 0.0804489031147397 469 97605 SGTC_884 0851-0618 334 µM 1.40156509983261 0.0843450386478008 no 417 0.0805225774445975 507 9642473 SGTC_268 camptothecin 39.6153 µM 1.40132428933308 0.0843818542504875 no 418 0.0805585605008606 593 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.39997439760215 0.0845884517380056 no 419 0.0807604926846158 491 4213774 SGTC_1000 4048-0884 8.67 µM 1.39951988950399 0.0846580983560865 no 420 0.0808285691233794 480 13040088 SGTC_2274 7947094 46.08 µM 1.38512407984653 0.086886357588076 no 421 0.0830072650190754 507 2971028 SGTC_3049 9092223 49.47 µM 1.38347461695666 0.0871444422928534 no 422 0.0832596925547985 459 8623917 SGTC_2070 5230947 200 µM 1.38293593803647 0.0872288510643526 no 423 0.0833422548214558 508 2835538 SGTC_536 3852-0578 10.6 µM 1.38287545266811 0.0872383326836192 no 424 0.0833515291376149 483 2869208 SGTC_433 pimozide 108 µM 1.38081858544611 0.0875612231071103 no 425 0.083667373754301 388 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_353 1988-1175 58.3 µM 1.37521955200513 0.0884446856083763 no 426 0.0845316942344386 461 2788357 SGTC_2213 7173844 200 µM 1.3741250682704 0.0886181557785773 no 427 0.0847014290969053 503 892728 SGTC_1348 1493-0373 93.8 µM 1.37042712995593 0.0892061350905125 no 428 0.0852768040122009 480 3010129 SGTC_1041 0206-0046 107 µM 1.36898322875142 0.0894365044974477 no 429 0.0855022587237143 493 50494 SGTC_2276 7947513 42.08 µM 1.36655998736766 0.0898241182262755 no 430 0.085881633067336 462 2105100 SGTC_973 1325-0077 65.9 µM 1.36448415184726 0.0901571538635529 no 431 0.086207619372831 538 2835149 SGTC_3207 9114163 49.47 µM 1.36234500369167 0.0905013057995646 no 432 0.0865445155980025 568 849233 SGTC_985 1493-0307 8.71 µM 1.36136696409344 0.0906589799689358 no 433 0.0866988753297191 431 3278274 SGTC_225 nsc-122657 1.016 µM 1.3602747173098 0.0908353068853151 no 434 0.0868715029778556 359 275685 SGTC_1012 4112-3522 18 µM 1.35612570386129 0.0915074224780805 no 435 0.0875295879291939 496 3112398 SGTC_3146 9095609 49.47 µM 1.35162178165415 0.0922411956555622 no 436 0.0882481693451589 500 17173999 SGTC_1124 fisetin 1.16336 µM 1.3512884508517 0.0922956740714444 no 437 0.0883015250765834 469 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_429 1112-0049 25.5 µM 1.35070375945708 0.0923912914939684 no 438 0.0883951737644687 486 2836170 SGTC_2060 5238662 140 µM 1.34996644543113 0.0925119725121838 no 439 0.0885133731526947 494 790130 SGTC_844 0330-0132 15.3 µM 1.34831472449949 0.0927827436874484 no 440 0.0887785891062673 512 2828079 SGTC_1550 gossypolone 36.6 µM 1.3482864040282 0.0927873914454812 no 441 0.0887831416638062 531 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1797 st048695 56.8 µM 1.33743825404319 0.094580403049238 no 442 0.0905398123207044 525 592262 YIL048W NEO1 SGTC_1375 2910-0797 186 µM 1.3373607915151 0.0945932974661272 no 443 0.0905524481583732 510 742508 SGTC_1695 st026914 34.495 µM 1.33640126311535 0.0947531280761722 no 444 0.0907090768479822 526 3289191 SGTC_144 4161-2749 112.381 µM 1.33275106544786 0.0953629676831658 no 445 0.091306754599642 443 797501 YMR168C CEP3 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.33129425672969 0.0956071621831892 no 446 0.0915461036296691 543 3256 An antibiotic and ribosome inhibitor. SGTC_1169 aniline yellow 25.8 µM 1.3274389844564 0.0962556136303154 no 447 0.092181755505266 488 6051 A DNA damaging agent. SGTC_176 1486-1328 72.834 µM 1.32705530358927 0.0963203246651093 no 448 0.0922451945876357 560 22310231 SGTC_2212 7123476 200 µM 1.32447925540086 0.0967556252081504 no 449 0.0926719640771799 424 1085715 SGTC_1278 0874-0585 172 µM 1.32289272469086 0.0970244350138457 no 450 0.0929355275476089 533 766306 SGTC_1332 1480-0653 17.5 µM 1.32143367190799 0.0972721294445823 no 451 0.093178402447857 537 5749438 SGTC_1799 st045822 46.1415 µM 1.32115936414724 0.0973187487557397 no 452 0.0932241162338509 508 3674992 SGTC_471 1-acyl-paf 4 µM 1.32050358706964 0.0974302661941499 no 453 0.0933334695964153 520 16759367 SGTC_1831 st055328 12 µM 1.31565410362728 0.0982578504926301 no 454 0.0941450826889288 546 1103068 SGTC_2311 7694451 200 µM 1.31479476109226 0.0984050362921231 no 455 0.0942894443142081 540 2163142 SGTC_3242 9133940 49.47 µM 1.31331192269075 0.0986593922731399 no 456 0.094538931314206 517 17248444 SGTC_1070 indatraline 8.81 µM 1.3128197142718 0.0987439286342347 no 457 0.0946218526829987 559 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2043 5101342 149 µM 1.30961265192118 0.0992960370129212 no 458 0.0951634530922243 547 678451 SGTC_1910 st062352 60.4 µM 1.30611993463416 0.0998998858076413 no 459 0.0957558874106698 539 2245730 SGTC_2902 5787006 60.46 µM 1.30187798258406 0.10063686955737 no 460 0.0964790500744678 516 591003 SGTC_751 0833-0568 350 µM 1.30130152968315 0.100737326006489 no 461 0.0965776319244908 547 6954252 SGTC_207 4185-0010 4.486 µM 1.30104146456756 0.100782670583865 no 462 0.0966221310652638 625 3761753 SGTC_2960 9079389 5.97 µM 1.2954480136278 0.101761542000571 no 463 0.0975828619915951 556 16457355 SGTC_1901 st060216 58.6 µM 1.29281017833976 0.10222556566037 no 464 0.0980383596140383 565 688792 SGTC_1805 st050013 60.3 µM 1.29196417238841 0.10237471269678 no 465 0.0981847761543672 504 4037144 SGTC_125 0133-0007 11.75 µM 1.29063234081864 0.102609829142957 no 466 0.0984155980310262 582 26541 SGTC_2441 5730946 39.09 µM 1.2890196483736 0.102895052786825 no 467 0.0986956279295331 562 1774275 SGTC_2400 5203494 178.7 µM 1.28738493927363 0.103184757768858 no 468 0.09898007554617 516 6777674 SGTC_2000 st075254 36.4 µM 1.28129854182653 0.104268603730638 no 469 0.100044412440252 515 17234175 SGTC_609 0986-0026 86.3 µM 1.28054591081135 0.104403200983334 no 470 0.100176604477766 578 2848610 SGTC_1998 st075797 76.8 µM 1.28037726519655 0.104433378089302 no 471 0.100206242856127 607 24208315 SGTC_113 0099-0221 2.5 µM 1.27648055831338 0.10513240794563 no 472 0.10089284754728 530 89219 SGTC_1800 st050079 29.0735 µM 1.2764704943377 0.10513421769458 no 473 0.10089462526234 725 3645560 SGTC_1314 1222-0010 41.1 µM 1.27488249303655 0.105420061672641 no 474 0.101175418260246 555 3526027 SGTC_945 3381-0768 11.3 µM 1.27013149859538 0.106278607711102 no 475 0.10201889662575 598 1126236 YIL048W NEO1 SGTC_2265 7929201 200 µM 1.26497759953742 0.107215660038673 no 476 0.102939678964301 563 1265108 SGTC_791 1348-1292 225 µM 1.26372205438207 0.107444835728148 no 477 0.103164903177161 668 5437054 SGTC_2082 5219693 150 µM 1.25901524805554 0.10830711542644 no 478 0.104012412186732 590 2834649 SGTC_2319 6033012 152.6 µM 1.25595906370215 0.108869663760793 no 479 0.104565406209619 512 847246 SGTC_2899 9053889 58.44 µM 1.25288422425449 0.109437762787837 no 480 0.105123921965426 546 6470052 SGTC_143 4032-1194 15.74 µM 1.24737410644203 0.110461117532935 no 481 0.106130178172525 680 1806963 SGTC_2201 6605497 169.863 µM 1.24567028114903 0.110778941137962 no 482 0.106442734255479 547 670741 SGTC_98 0074-0023 107.663 µM 1.24539267981322 0.110830785605675 no 483 0.106493721381745 618 3563821 SGTC_1428 4049-0204 61.7 µM 1.24318639825173 0.111243446082691 no 484 0.106899576877959 599 X1428 SGTC_1026 k007-1105 30.6 µM 1.24142634652997 0.111573432134425 no 485 0.107224145651437 675 7066794 SGTC_159 3970-0959 50 µM 1.24095676622776 0.111661590371202 no 486 0.107310860276352 805 6615653 SGTC_615 k087-0205 167 µM 1.23294529524045 0.113173334273266 no 487 0.108798087326892 569 9642773 SGTC_2034 5197015 53.07 µM 1.22877833347325 0.113965377097501 no 488 0.109577463555337 606 780676 SGTC_853 0419-0306 21 µM 1.22761178567546 0.11418781668881 no 489 0.109796367715554 566 762713 SGTC_779 1360-0071 233 µM 1.22708623157519 0.114288131330462 no 490 0.109895091097077 638 7566 SGTC_1493 4348-0038 111 µM 1.22648813787448 0.114402368224506 no 491 0.110007518252867 651 800424 SGTC_94 0334-0113 514.748 µM 1.22524348236506 0.114640360062091 no 492 0.110241747910841 593 6795178 SGTC_1956 st077085 54 µM 1.22349460033151 0.11497536057829 no 493 0.110571471198512 637 24208685 SGTC_1193 1488-0126 41.5 µM 1.22252539295355 0.115161313002359 no 494 0.110754503630587 608 1384710 SGTC_2734 clemastine 41.6 µM 1.21599064085295 0.116420654599702 no 495 0.111994243641399 445 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.21343455192429 0.116915898376758 no 496 0.112481861419493 629 688669 SGTC_111 0083-0039 52.457 µM 1.21172826817769 0.117247321818402 no 497 0.112808207274136 459 759313 SGTC_2520 obtusaquinone 4.71 µM 1.21100366628838 0.117388267437317 no 498 0.112946999787674 603 5967872 SGTC_1316 1272-0050 65.9 µM 1.20964367481379 0.117653129426858 no 499 0.113207825787821 609 7340392 SGTC_367 0335-0881 7.1 µM 1.20760671359693 0.118050623867009 no 500 0.113599287805432 643 23828853 SGTC_122 0236-0016 402.397 µM 1.20456891148624 0.118645186374707 no 501 0.114184882134624 684 6808838 SGTC_1644 st010134 20.9 µM 1.2007145993924 0.119402598328335 no 502 0.114930964476536 577 3818134 SGTC_2918 7977171 22.06 µM 1.20042517309326 0.119459610975941 no 503 0.114987128597007 596 2236483 SGTC_12 0849-0099 9.267 µM 1.20039964562229 0.119464640427077 no 504 0.114992083222859 597 6071388 SGTC_2745 rifampicin 24.3 µM 1.19895274406205 0.119749954848438 no 505 0.115273160520746 471 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2709 st078560 56 µM 1.1955288290934 0.120427029354756 no 506 0.1159402397551 623 17250903 SGTC_1158 4092-0494 91.8 µM 1.19520057130206 0.120492083241009 no 507 0.116004337702039 651 1148199 SGTC_3233 9132340 49.47 µM 1.18938055675246 0.121649600272503 no 508 0.117144974189455 607 17682950 SGTC_932 2857-0803 154 µM 1.18873864129094 0.121777744878713 no 509 0.117271264931333 666 674898 SGTC_560 2332-1943 155 µM 1.18695134671049 0.122135039335276 no 510 0.117623406051402 620 21177716 SGTC_3094 9117742 49.47 µM 1.18687700916811 0.12214991593071 no 511 0.117638068576699 666 17149698 SGTC_1337 1486-1011 40.3 µM 1.18451033624514 0.122624204980803 no 512 0.118105553564535 616 X1337 SGTC_472 calcifediol 10 µM 1.17915528748971 0.123702139087986 no 513 0.119168173346829 562 5283731 A vitamin D metabolite. SGTC_2859 9028643 45.46 µM 1.17878335682559 0.123777251781177 no 514 0.119242226608592 590 17151580 SGTC_841 0251-0215 91.2 µM 1.17759177333053 0.124018111209073 no 515 0.119479695561464 700 3888614 SGTC_2640 pentamidine 10.38 µM 1.17684540424605 0.124169144658091 no 516 0.119628608212892 698 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_100 0086-0128 49.5915 µM 1.17675328096635 0.124187795420392 no 517 0.119646997362536 692 93297 SGTC_1635 st007035 42.4 µM 1.17512741365454 0.124517281930731 no 518 0.119971872313319 807 3716403 SGTC_690 glyoxal 20.3 µM 1.1725189319805 0.125047173885717 no 519 0.120494387866558 655 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3241 9133421 49.47 µM 1.1694452322561 0.125673590059486 no 520 0.121112147433532 610 17018221 SGTC_2519 cryptotanshinone 88.04 µM 1.1688695401433 0.125791158394599 no 521 0.12122809869771 630 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2467 5474540 200 µM 1.1681230104014 0.12594372955049 no 522 0.121378574932086 642 5413519 SGTC_839 0122-0028 230 µM 1.16759346636393 0.126052032705249 no 523 0.121485393457259 692 759448 SGTC_2315 7733312 200 µM 1.16353745999767 0.126883726783951 no 524 0.122305754388072 599 726316 SGTC_1623 st003709 20.3 µM 1.16117216102807 0.127370496792483 no 525 0.122785946810206 717 16192618 SGTC_2343 7990716 14.84 µM 1.16081703004415 0.127443693464347 no 526 0.122858157921738 670 6456862 SGTC_2462 5162487 171.77 µM 1.15648141731505 0.128339673214725 no 527 0.123742148095699 662 2259986 SGTC_2676 harmalol 100 µM 1.15608746151259 0.128421302703638 no 528 0.123822692073477 678 5459187 A monoamine oxidase inhibitor SGTC_905 2-aminofluorene 215 µM 1.15574634951302 0.128492011817928 no 529 0.123892461813383 709 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1471 k673-0312 37 µM 1.15552524881909 0.128537858217962 no 530 0.123937699596336 637 24099884 SGTC_2852 9023854 51.95 µM 1.15460439027456 0.128728925220188 no 531 0.124126234007983 662 19798528 SGTC_421 streptovitacin 30 mM 1.15354077863965 0.12894985689144 no 532 0.12434424496342 690 91467 include heat shock SGTC_195 4234-0266 16.654 µM 1.15310112742248 0.129041257295415 no 533 0.12443443947549 712 2303354 SGTC_203 k066-0004 30.888 µM 1.14897779232906 0.129900656247924 no 534 0.125282569013689 782 6795412 SGTC_262 fenpropimorph 62.5 µM 1.14854416084358 0.129991264870309 no 535 0.125371996728235 615 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_621 3584-0052 32.1 µM 1.14757318357975 0.130194312161957 no 536 0.125572402701339 698 2273927 SGTC_2130 NSC 7 2.4545 µM 1.14661074429892 0.130395790490747 no 537 0.125771266959352 707 21448 SGTC_1790 st045711 43.5 µM 1.1461996532389 0.130481914542378 no 538 0.125856275673984 651 585119 SGTC_1668 st014914 51.6 µM 1.14548693370201 0.130631323317423 no 539 0.126003752497312 649 2839556 SGTC_205 1486-1330 71.903 µM 1.14398547895443 0.130946463134142 no 540 0.12631482958559 613 4118834 SGTC_1343 1487-0095 224 µM 1.14233756526805 0.131292947422822 no 541 0.126656866169904 648 4560101 YGL055W OLE1 SGTC_25 0118-0223 35.662 µM 1.1414070252447 0.131488878797552 no 542 0.126850291277425 667 5333628 SGTC_1783 st039459 87.517 µM 1.13911631756407 0.131972062198478 no 543 0.127327321225168 734 729761 SGTC_832 4083-0019 164 µM 1.13826043529077 0.132152908964115 no 544 0.127505874801203 867 1990758 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.13629370102587 0.132569124461092 no 545 0.127916833065172 704 6728940 SGTC_967 1306-0166 352 µM 1.1360559248163 0.132619505624914 no 546 0.12796657979852 672 4437607 SGTC_952 1185-0122 232 µM 1.13432343907029 0.132986991176081 no 547 0.128329450363188 653 678600 SGTC_2477 5967686 25.23 µM 1.13330562419372 0.133203211181465 no 548 0.128542965368674 664 776118 SGTC_710 3448-4187 58 µM 1.12813928553861 0.134304454453756 no 549 0.12963055009338 773 3946412 SGTC_1369 1866-0067 208 µM 1.12566135246288 0.134834856673576 no 550 0.130154444120643 747 3531355 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.12340854169237 0.135318317040036 no 551 0.13063201187607 735 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3103 9120822 49.47 µM 1.12039372137076 0.135967164160684 no 552 0.131273009662017 707 17141819 SGTC_2178 5812956 200 µM 1.11998318000614 0.136055685034014 no 553 0.131360464898228 664 5403383 SGTC_2662 daunorubicin 22.37 µM 1.11761456290895 0.13656717625497 no 554 0.131865823171006 651 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2732 terfenadine 20 µM 1.11561490308711 0.137000015452597 no 555 0.132293505044482 638 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_128 0906-2981 13.371 µM 1.11360964032294 0.137435007864554 no 556 0.132723344437749 632 6740226 SGTC_2718 lomofungin 53.02 µM 1.11235439178481 0.13770778255579 no 557 0.132992903054553 673 5351222 A RNA synthesis inhibitor. SGTC_2341 7987486 176.74 µM 1.1112666995516 0.137944444620829 no 558 0.133226784337133 717 1258686 SGTC_224 benfluorex 43.875 µM 1.1107384840378 0.138059474741038 no 559 0.133340466039701 619 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2679 rapamycin 1 nM 1.11045727675574 0.138120740261019 no 560 0.133401014237008 782 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_292 k038-0015 474 µM 1.10689182117894 0.138899139753477 no 561 0.134170351215194 650 46368540 SGTC_435 c-PAF 6.7 µM 1.10617002971336 0.139057081932904 no 562 0.134326466134071 711 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3232 9132874 49.47 µM 1.10124647078299 0.140137714283349 no 563 0.135394700718932 668 3784940 SGTC_317 4495-0002 170 µM 1.10091716108457 0.140210194814597 no 564 0.135466356191151 644 15991618 SGTC_527 4476-4215 268 µM 1.09505439820479 0.141504841921393 no 565 0.136746402618607 713 4418754 SGTC_2437 5741531 144.16 µM 1.09416081165697 0.141702877676681 no 566 0.136942227689001 751 2262990 SGTC_187 1488-2104 32.728 µM 1.0928164336885 0.142001170895904 no 567 0.137237202364138 735 2852859 SGTC_2524 avocatin b 10.57 µM 1.09026406800739 0.142568663704821 no 568 0.137798419221211 662 6710748 SGTC_5 0352-0601 109.883 µM 1.0899440212454 0.142639930942941 no 569 0.137868901771804 677 762456 SGTC_2657 nystatin 74.44 µM 1.08969768961795 0.142694799875651 no 570 0.137923167095989 745 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1442 4112-3290 3 µM 1.08839791842417 0.142984552600185 no 571 0.138209739849633 747 704353 SGTC_1039 k821-0043 94 µM 1.08810958175738 0.143048884167453 no 572 0.138273367118516 734 15992768 SGTC_1530 rhein 70.4 µM 1.08658558886485 0.143389231116736 no 573 0.138609998386602 764 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2871 9038510 12.99 µM 1.08348005683552 0.144084467664482 no 574 0.139297699111488 766 4945164 SGTC_579 4491-1009 110 µM 1.08214818398734 0.144383329837339 no 575 0.139593344184468 921 1271041 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.07869922648908 0.145159190309903 no 576 0.140360915311056 751 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_341 1486-1430 230 µM 1.07783245996338 0.14535461416783 no 577 0.140554265405828 708 2054753 YPL210C SRP72 SGTC_1101 ebselen 5.29 µM 1.07366843196931 0.146295915449582 no 578 0.141485657387851 786 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_823 0417-1665 178 µM 1.07171029667151 0.146739974566258 no 579 0.141925087274857 737 3429856 SGTC_3225 9130819 49.47 µM 1.07107625810644 0.146883953245842 no 580 0.142067571240651 740 4547121 SGTC_2890 9046729 58.44 µM 1.06802607556924 0.147577918563104 no 581 0.142754374853503 668 903329 SGTC_2194 5927483 104.545 µM 1.06271076619683 0.148792477087191 no 582 0.143956568476463 773 760979 SGTC_1468 k284-1086 134 µM 1.05938534934868 0.149555728990492 no 583 0.144712159569344 793 15996457 SGTC_1669 st015249 58.4 µM 1.05844432567809 0.149772186834475 no 584 0.144926460115001 756 722793 SGTC_1721 st082152 9.2685 µM 1.05581897261795 0.150377184879583 no 585 0.145525464251528 692 5296051 SGTC_748 act1.228 77.9 µM 1.05486210713121 0.150598093555349 no 586 0.145744197395894 770 4421505 YNR035C ARC35 SGTC_3311 9131146 2.8755 µM 1.05462797315802 0.150652180262703 no 587 0.145797752515883 744 4900406 YPR165W RHO1 SGTC_546 peri-Naphthalide 147 µM 1.05352980612721 0.150906037710135 no 588 0.146049120528954 744 223824 A penicillin ester. SGTC_868 0527-0199 213 µM 1.05305008863177 0.151017020763581 no 589 0.146159018125387 770 2849450 SGTC_2021 4019055 173 µM 1.05217236854642 0.151220222633177 no 590 0.146360237153 870 44827708 YER133W GLC7 SGTC_2258 7960471 200 µM 1.05197993023122 0.151264798522273 no 591 0.146404378857542 640 2974708 SGTC_1855 st056195 39.6 µM 1.04999052155457 0.151726131931251 no 592 0.146861235312064 725 4028379 SGTC_66 0109-0187 42.4 µM 1.04870495510069 0.152024744860361 no 593 0.147156966489144 689 759417 SGTC_206 4546-0025 72.014 µM 1.04607126168287 0.152637720557546 no 594 0.14776406620337 813 6620745 YIL048W NEO1 SGTC_102 gallobenzophenone 83.616 µM 1.04426628956993 0.153058762168237 no 595 0.148181102397839 754 70837 SGTC_2474 5321570 43.32 µM 1.04402536409705 0.153115020470894 no 596 0.148236827396634 760 2841384 SGTC_2211 7117706 200 µM 1.04187773392388 0.153617117319699 no 597 0.148734184250878 727 822771 SGTC_563 tetrahydrosecaminediol 614 µM 1.04089078203097 0.15384822311905 no 598 0.148963120180562 801 334274 A psychoactive constituent of the cannabis plant. SGTC_3175 9106517 49.47 µM 1.04004878274729 0.154045568455609 no 599 0.149158618532365 744 41468073 SGTC_74 000s-0487 160.283 µM 1.0384167565685 0.154428554697271 no 600 0.149538035840883 758 677548 SGTC_732 3970-1727 52.7 µM 1.03437457746901 0.155379837688847 no 601 0.150480542264256 775 1275699 SGTC_3144 9087057 49.47 µM 1.0329890117957 0.155706803569554 no 602 0.15080452045779 737 17249618 SGTC_3354 9151612 71.43 µM 1.03221960930231 0.155888563016604 no 603 0.150984625431532 799 27261949 SGTC_1024 4507-0395 26 µM 1.03012352685792 0.156384439392962 no 604 0.151476011179032 733 4201836 SGTC_1848 st056003 16.4 µM 1.02838270564384 0.156797059382298 no 605 0.151884920216332 807 146492 SGTC_2683 piperine 63.03 µM 1.02371312511536 0.157907406869549 no 606 0.152985397079093 769 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1014 4130-3005 69.3 µM 1.02370934354086 0.157908308151393 no 607 0.152986290416958 783 743608 SGTC_983 1491-0821 12.2 µM 1.02323453197885 0.158021499239366 no 608 0.153098484704354 806 46495113 SGTC_2352 9027995 87.8 µM 1.02239117951723 0.158222678677654 no 609 0.15329789677166 723 2997347 SGTC_3253 9135987 49.47 µM 1.02219386700043 0.158269771293901 no 610 0.153344576468677 726 4182430 SGTC_1047 2043-3044 82 µM 1.02061608372891 0.1586466719128 no 611 0.153718183137974 798 669592 SGTC_2581 avocatin a 64 µM 1.02020343577429 0.158745342197617 no 612 0.153815994255578 790 6710728 A skin care supplement. SGTC_547 1120-0019 610 nM 1.0201744129812 0.158752283494567 no 613 0.153822875160935 772 3676939 SGTC_1561 5-methoxyflavone 52.9 µM 1.012764461161 0.16053101035922 no 614 0.155586339805085 754 94525 SGTC_212 3807-4682 38.772 µM 1.00989655595375 0.161222919742592 no 615 0.156272426450583 925 3125501 YBL034C STU1 SGTC_3002 9075603 71.4286 µM 1.00727271806742 0.161857647226972 no 616 0.156901868224705 802 20105405 SGTC_1655 st012546 55.1 µM 1.00599028327208 0.162168470080313 no 617 0.157210122099585 767 720985 YLR208W SEC13 SGTC_1364 1653-0028 37.6 µM 1.00523716519486 0.162351183820878 no 618 0.157391331634008 791 5718652 SGTC_139 0099-0334 718.624 µM 1.00505543446414 0.162395293517177 no 619 0.157435078851681 922 97690 SGTC_625 k213-0058 121 µM 1.00390994409708 0.162673506538668 no 620 0.157711011504176 958 3655420 SGTC_3003 9075612 71.4286 µM 1.00291990990097 0.162914212502941 no 621 0.157949752721657 772 6501993 SGTC_4 0960-0234 25.671 µM 0.999767144865853 0.163682283032697 no 622 0.158711604616984 765 6821112 SGTC_15 0266-0086 27.098 µM 0.998853450129633 0.163905314231557 no 623 0.158932844478779 904 1712902 YIL048W NEO1 SGTC_2388 9080168 200 µM 0.996473915967734 0.164487079204444 no 624 0.159509967279846 755 15943073 SGTC_81 0411-0046 9.971 µM 0.995896461785994 0.164628460757856 no 625 0.159650227316115 733 12925265 SGTC_1390 3413-2614 145 µM 0.995869322739857 0.164635107309239 no 626 0.159656821207067 819 3421432 SGTC_899 1083-0020 478 µM 0.994071676403929 0.165075751260576 no 627 0.160093986695303 824 767123 SGTC_2304 7443016 91.4 µM 0.992132199602431 0.165552016530315 no 628 0.160566520486786 743 939854 SGTC_2719 novobiocin 32.65 µM 0.991332564581262 0.165748636421895 no 629 0.160761608402648 769 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_454 lyso-paf C-16 6.67 µM 0.987962638636971 0.166578915596366 no 630 0.161585473102716 836 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1057 3448-5381 134 µM 0.985613210837633 0.167159350791292 no 631 0.162161476376539 840 5497911 SGTC_1656 st012921 11 µM 0.985042585247566 0.167300522609547 no 632 0.162301576763937 760 6732821 SGTC_860 0443-0016 25.1 µM 0.984963366912488 0.167320127165946 no 633 0.162321032730961 844 5337942 SGTC_627 1391-0720 175 µM 0.984812112287243 0.167357563014324 no 634 0.162358184976463 789 997839 SGTC_900 1112-0045 141 µM 0.984692483260802 0.167387175280763 no 635 0.16238757303533 691 56211 YIL048W NEO1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.983493176525329 0.167684231204346 no 636 0.162682385978531 852 16623 A steroid. SGTC_1596 piperlongumine 63 µM 0.982925118548613 0.167825051728982 no 637 0.162822147120628 884 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1264 0783-0040 158 µM 0.982017126190482 0.168050299428181 no 638 0.163045705520049 782 2855798 SGTC_1511 0906-3109 28.5 µM 0.981625587274298 0.168147489371747 no 639 0.163142168546713 892 2882180 SGTC_1684 st024538 14.6195 µM 0.979338984834443 0.168715804553578 no 640 0.163706256985673 828 6732859 SGTC_1282 0886-0010 32.4 µM 0.978469006247066 0.168932353983657 no 641 0.163921206578435 915 2836211 YNL267W PIK1 SGTC_2257 7960413 200 µM 0.978434603002936 0.168940921084525 no 642 0.163929710508063 875 2974689 YIL048W NEO1 SGTC_2123 5259487 200 µM 0.975281115690733 0.16972738808548 no 643 0.164710417580241 865 2173474 SGTC_2821 7996764 71.43 µM 0.974413138426121 0.169944269556141 no 644 0.164925724280862 853 2987135 SGTC_2936 9038235 15.59 µM 0.971485137956024 0.170677198860101 no 645 0.165653375232084 797 4749415 SGTC_2357 9067248 200 µM 0.970768538054683 0.170856883991191 no 646 0.165831776524576 779 9150235 SGTC_2405 ticlatone 3.52 µM 0.970658554161957 0.170884472811161 no 647 0.1658591685793 825 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_342 k048-0088 23.3 µM 0.970125368861496 0.171018259644932 no 648 0.165992002576331 819 6820570 SGTC_2393 9031399 185.94 µM 0.970120614674602 0.17101945286661 no 649 0.165993187309811 835 1526623 YDL150W RPC53 SGTC_852 0418-0143 439 µM 0.969845774019166 0.171088442343421 no 650 0.166061686317776 909 5369229 SGTC_476 mead acid 10 µM 0.969118922418193 0.171270979693239 no 651 0.166242928794512 786 5312531 An omega 9 fatty acid. SGTC_768 0384-0033 77.3 µM 0.968415209950286 0.17144782459998 no 652 0.166418523143184 833 3965305 YMR134W ERG29 SGTC_2909 7941780 10.49 µM 0.967231085680885 0.171745661635049 no 653 0.166714262763936 868 1243215 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.965287575123904 0.172235219294308 no 654 0.167200396659766 907 688788 SGTC_891 0929-0073 133 µM 0.963854498017636 0.172596771872156 no 655 0.16755943962172 849 5603632 SGTC_966 1300-0360 30.2 µM 0.963702867618611 0.172635055160478 no 656 0.167597458117272 815 70588 SGTC_2839 9003951 25.97 µM 0.962305851770016 0.172988025140991 no 657 0.167947995188094 818 2990634 SGTC_3054 9094397 49.47 µM 0.96199399533715 0.173066881509423 no 658 0.168026310110101 855 2598354 SGTC_1256 0570-0116 285 µM 0.958798804166474 0.173876139941483 no 659 0.168830055878559 793 410638 SGTC_2521 angolensin 13.4 µM 0.956800852510947 0.174383389725979 no 660 0.169333890942262 811 821428 A flavenoid. SGTC_2162 5663267 200 µM 0.956349701194341 0.174498060217159 no 661 0.169447793819668 882 6456493 SGTC_1004 4084-0029 199 µM 0.95482253713209 0.174886579456616 no 662 0.169833724119637 896 716894 YLR208W SEC13 SGTC_869 0564-0080 44.1 µM 0.951140767950512 0.175825497598361 no 663 0.170766460929983 833 6843321 SGTC_3185 9108267 49.47 µM 0.950785657142661 0.175916225838872 no 664 0.170856597487493 842 4910486 SGTC_2606 farnesol 9.78 µM 0.950214875579888 0.176062118509233 no 665 0.171001540793326 847 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_356 1634-0012 32.5 µM 0.9478422716087 0.176669380488859 no 666 0.171604878557646 888 735457 SGTC_311 1315-0136 58 µM 0.945678348252556 0.177224384497582 no 667 0.17215633459785 861 6759207 SGTC_2677 mitomycin C 100 µM 0.945557227043808 0.177255482226387 no 668 0.172187234614909 829 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3119 9125183 49.47 µM 0.945093542075911 0.177374564645898 no 669 0.172305561001904 709 22695334 SGTC_272 doxorubicin 8.13 µM 0.944018970116183 0.177650727651343 no 670 0.172579977189117 895 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.943002546034796 0.17791219630652 no 671 0.172839800319237 905 688664 SGTC_397 arbidol 50 µM 0.94069192325636 0.178507491803078 no 672 0.173431379597252 919 131410 A RNA synthesis inhibitor. SGTC_1597 7-benzyloxygramine 47.5 µM 0.940312587462211 0.178605341443195 no 673 0.173528622405944 953 260807 SGTC_670 4204-0025 119 µM 0.93723732404834 0.179399851883048 no 674 0.17431824732828 905 719039 SGTC_2714 st079313 56.9 µM 0.936462820523264 0.179600298682361 no 675 0.174517473285907 857 2939799 SGTC_1446 4239-0190 62 µM 0.936035023835032 0.179711075703256 no 676 0.174627577630011 888 1340085 SGTC_994 3910-0338 138 µM 0.935989279856158 0.1797229235471 no 677 0.174639353614754 898 3479481 SGTC_2485 5633444 17.78 µM 0.935281018638988 0.179906428194511 no 678 0.174821747376188 834 5724239 SGTC_13 0199-0087 65 µM 0.932985046815598 0.180502104225065 no 679 0.17541384448863 903 4589825 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.932901363949323 0.180523838581069 no 680 0.175435449044386 742 88881 An O-methylated flavonoid and antioxidant. SGTC_1361 1608-0041 5.61 µM 0.932856727284864 0.180535432415907 no 681 0.17544697366194 871 X1361 SGTC_1398 3558-0053 112 µM 0.932441341702056 0.180643346201412 no 682 0.17555424393425 813 4532369 SGTC_1019 4262-0212 3.4 µM 0.932354581701061 0.180665890847318 no 683 0.175576654312913 971 4677213 SGTC_923 1900-2434 73.3 µM 0.929198781166528 0.181487126700765 no 684 0.176393039489697 853 5910570 SGTC_2659 sanguinarine 24.21 µM 0.92869302561296 0.181618956688616 no 685 0.176524098106085 831 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_439 amiodarone 34.4 µM 0.926551900753429 0.182177724821346 no 686 0.177079619059483 872 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1937 st074714 47.2 µM 0.925980975954935 0.182326900008242 no 687 0.177227933439034 862 17250970 SGTC_3273 9137859 49.47 µM 0.925839189590956 0.182363958759813 no 688 0.177264778742914 889 2377234 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.922902297109782 0.183132633444954 no 689 0.178029061713586 820 1241132 A phosphatase inhibitor. SGTC_2066 5222451 176 µM 0.922003475041345 0.183368286037397 no 690 0.178263381523546 952 2281147 SGTC_2129 girgensonine 121.053 µM 0.921821710238373 0.183415963988761 no 691 0.178310790595999 927 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1071 trifluoperazine 6.31 µM 0.921104122452889 0.18360426685626 no 692 0.178498034075565 910 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3283 9109332 35.8195 µM 0.919745231536765 0.183961184596464 no 693 0.178852954924974 798 17027281 SGTC_2146 5545642 200 µM 0.916306375118564 0.18486634139119 no 694 0.179753112615852 907 825326 SGTC_1267 0828-0272 9.49 µM 0.916205471589073 0.18489294239364 no 695 0.179779568111588 910 745334 SGTC_3020 9089140 49.47 µM 0.9145199793177 0.185337637135767 no 696 0.180221842260996 898 17217859 SGTC_3095 9117207 49.47 µM 0.913874471016775 0.185508121636659 no 697 0.180391404703372 857 17015229 SGTC_2068 5226020 147 µM 0.913280569808604 0.185665062183577 no 698 0.180547499346621 946 1810509 SGTC_2728 chlorpromazine 9.18 µM 0.911746857432721 0.186070732138924 no 699 0.180950995629934 824 2726 A thorazine and dopamine antagonist. SGTC_361 000s-0510 1.45 µM 0.911291474545885 0.186191287524658 no 700 0.181070908625751 869 660 SGTC_1027 k015-0025 8.67 µM 0.911268677498873 0.18619732395276 no 701 0.181076912931213 888 3598955 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.909322811811213 0.186713016480449 no 702 0.18158987633709 935 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1672 st016598 6.51 µM 0.908552015007658 0.186917536981863 no 703 0.181793322749669 864 4665860 YNL267W PIK1 SGTC_3019 9081971 49.47 µM 0.908269832919167 0.186992444830682 no 704 0.181867838374246 963 16451803 SGTC_1817 st052116 64.4 µM 0.907887768568705 0.18709389694292 no 705 0.181968760275486 889 4361398 SGTC_3050 9093513 49.47 µM 0.907612783789116 0.187166936563751 no 706 0.182041418888178 920 25236664 SGTC_1771 st048882 4.1505 µM 0.903432401589111 0.188279472516987 no 707 0.183148224933101 897 4580403 SGTC_1138 3761-0006 1.03 µM 0.902618417758926 0.188496573757309 no 708 0.183364224092846 918 12061087 SGTC_960 1222-0186 7.7 µM 0.901981617092284 0.188666525270804 no 709 0.183533316522141 910 3126296 SGTC_1315 1237-0019 3.69 µM 0.901798604755098 0.188715385690655 no 710 0.183581930550924 944 825140 SGTC_2592 piperlongumine 83.33 µM 0.898632339838026 0.189561945713855 no 711 0.18442426349103 842 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.89671420487055 0.190075929531246 no 712 0.184935719412634 916 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2241 6772625 37.8075 µM 0.895240319714583 0.190471453403628 no 713 0.185329317764643 889 2285411 SGTC_2320 7373003 200 µM 0.894532382266597 0.190661611216472 no 714 0.185518555940523 920 5415828 SGTC_2002 4023503 131 µM 0.889388375728777 0.192046830335597 no 715 0.186897195023015 1029 4736863 YCR052W RSC6 SGTC_2916 7875993 68.79 µM 0.888782666887205 0.192210344757161 no 716 0.187059946497791 914 1299250 SGTC_1883 5-benzylidenerhodanine 20 µM 0.888720570339158 0.192227112872301 no 717 0.187076636538008 955 1273210 SGTC_386 1509-0011 3.07 µM 0.887203746137349 0.192636983246409 no 718 0.187484607963541 977 3107280 SGTC_926 2268-1401 59.4 µM 0.887085778154944 0.19266888246779 no 719 0.187516360156873 939 2931578 SGTC_1231 0242-0792 125 µM 0.884612041204241 0.193338538525768 no 720 0.18818295503903 913 3707635 SGTC_1184 1269-1718 139 µM 0.883707721407467 0.193583697626763 no 721 0.18842700553799 950 5403821 SGTC_1835 st008666 49.2 µM 0.881486658591347 0.194186627012946 no 722 0.189027235965759 832 690455 SGTC_2569 tetrandrine 100 µM 0.880101516974033 0.194563215758551 no 723 0.189402158714166 833 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1262 0737-0114 49.6 µM 0.88000811065784 0.194588626814002 no 724 0.189427457899556 997 765919 SGTC_2929 9013348 24.6 µM 0.878277088008881 0.195059914508639 no 725 0.18989668328682 897 2995952 SGTC_2760 etidronate 98.04 µM 0.877409266876185 0.195296448131152 no 726 0.190132190787415 915 3305 A chelator and antioxidant. SGTC_2360 9040895 200 µM 0.876652560444929 0.195502838455238 no 727 0.190337690620619 880 4914414 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.875929853672974 0.195700079050224 no 728 0.190534084433064 950 2333 A French combination drug. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.873064104473877 0.19648338563896 no 729 0.191314068894782 1008 5106787 A p450 inhibitor. SGTC_3333 9141820 12.094 µM 0.871380696097674 0.196944402865182 no 730 0.191773161201268 900 1939433 SGTC_282 k297-0036 65.7 µM 0.868906962479047 0.197623045029186 no 731 0.192449010511857 941 5061378 SGTC_895 0964-0006 13.7 µM 0.865950434627478 0.198435988206582 no 732 0.193258671752502 953 6738897 SGTC_415 dibenzyl ketone 100 µM 0.865195213353417 0.198643971086978 no 733 0.193465826086132 956 7593 SGTC_1931 st074438 57.1 µM 0.862887578961525 0.199280292216449 no 734 0.194099640284799 969 2787313 SGTC_2426 5582046 32.21 µM 0.862760251870879 0.19931543785895 no 735 0.194134648690814 952 2251934 SGTC_1762 st045503 25.4615 µM 0.862412164043166 0.199411538347717 no 736 0.19423037458216 967 4645554 SGTC_2198 6589944 200 µM 0.858053006924595 0.20061738002143 no 737 0.195431597249606 882 5290268 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.857674135044183 0.200722390958745 no 738 0.195536213051874 1042 65057 A dermal irritant. YDR527W RBA50 SGTC_1575 cyproterone acetate 48 µM 0.857364402427418 0.200808263252845 no 739 0.195621763070352 930 9880 An androgen receptor antagonist and liver toxin. SGTC_1661 st013063 9.66 µM 0.855274593260779 0.201388231613009 no 740 0.196199574696959 1037 721395 SGTC_872 0588-0139 234 µM 0.854755237780553 0.201532519871517 no 741 0.196343331757114 1017 2047100 SGTC_3194 9111903 49.47 µM 0.85430994137546 0.201656282214234 no 742 0.196466640168972 949 17087251 SGTC_1160 4092-0570 10.5 µM 0.853246394608994 0.201952060582431 no 743 0.196761340048732 957 4994975 SGTC_2663 amphotericin b 100 µM 0.852774195796772 0.202083464942858 no 744 0.196892268145338 958 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2934 9036370 36.88 µM 0.852498836738868 0.202160115983895 no 745 0.196968642186466 993 6462800 SGTC_2694 st077685 81.9 µM 0.852325779974425 0.202208298281152 no 746 0.197016650670864 937 2838096 SGTC_2418 pentamidine 31.67 µM 0.852020400569919 0.202293338476004 no 747 0.197101384670246 945 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1181 1222-0449 220 µM 0.851716937400111 0.202377866236744 no 748 0.197185608812288 974 658318 SGTC_153 4077-0274 519.67 µM 0.849297125324256 0.203052645098825 no 749 0.197857990021727 939 3121976 SGTC_614 0462-0418 107 µM 0.848530196145013 0.203266787862269 no 750 0.198071381567357 893 5188303 SGTC_1801 st050089 28.441 µM 0.846588040242711 0.203809681147035 no 751 0.198612391218421 1020 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2992 9074591 71.4286 µM 0.842933192005192 0.204833666066346 no 752 0.19963290440879 950 17741321 SGTC_784 4579-0127 173 µM 0.84266496409664 0.204908936238542 no 753 0.199707923553751 1036 1948547 SGTC_1190 1486-1332 13 µM 0.841630910192233 0.20519926653255 no 754 0.199997290926104 977 4150046 SGTC_2026 5148700 152 µM 0.838740891436151 0.206011989357595 no 755 0.200807363192586 985 79838 SGTC_2653 dihydrofissinolide 100 µM 0.837305770086961 0.206416278448876 no 756 0.201210358363209 1002 6857746 SGTC_1945 st075991 56.6 µM 0.837020795260433 0.206496614823496 no 757 0.201290439564278 901 1084980 SGTC_1162 k048-0130 20.1 µM 0.83700186535388 0.20650195195106 no 758 0.201295759762232 965 6797406 SGTC_1736 st036774 51 µM 0.836970899295158 0.206510682746429 no 759 0.201304462869241 1035 1272247 SGTC_2181 6316240 54.2555 µM 0.836855837186391 0.206543126108343 no 760 0.201336803408622 946 12779990 SGTC_2696 st077691 74.316 µM 0.835959586749824 0.206795939715171 no 761 0.201588819365245 908 757133 SGTC_1488 4013-0813 75.9 µM 0.834324854666654 0.207257535151117 no 762 0.202048974818891 953 2910057 SGTC_2534 helenine 20.12 µM 0.829103368697053 0.208735989346754 no 763 0.203522958856973 972 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_830 4076-0286 57.8 µM 0.827378768188695 0.209225668972451 no 764 0.204011205408809 1091 6866659 SGTC_2996 9066192 71.4286 µM 0.824956051739197 0.209914711279199 no 765 0.204698271014742 1008 6472854 SGTC_2289 7946404 165.07 µM 0.824694433591188 0.209989197529856 no 766 0.204772546363417 1052 1246120 YPR165W RHO1 SGTC_2987 9018338 71.43 µM 0.823876966105013 0.210222041720995 no 767 0.205004734767833 1016 5055682 SGTC_3064 1327-0027 10 µM 0.822876593584482 0.210507190075068 no 768 0.205289087227176 885 16000455 YPR107C YTH1 SGTC_1103 duloxetine 36.1 µM 0.822376651174018 0.210649779774234 no 769 0.205431281905989 1102 60835 A selective serotonin reuptake inhibitor. SGTC_368 fentichlor 4.58 µM 0.821555297517815 0.210884162882674 no 770 0.205665019993796 948 7329 A pesticide. SGTC_3255 9139072 49.47 µM 0.820800538200198 0.211099677266673 no 771 0.205879945994581 1047 17646060 SGTC_3040 9091894 49.47 µM 0.820145347480217 0.211286865401078 no 772 0.206066626738259 941 25236966 SGTC_1449 4112-4002 201 µM 0.819881589409782 0.21136224858405 no 773 0.2061418065478 945 2059539 SGTC_642 0335-0876 158 µM 0.818477791838675 0.211763724885303 no 774 0.206542208991708 1018 6812350 SGTC_1187 1391-0724 117 µM 0.816943008501801 0.212203172441615 no 775 0.206980498989386 1018 6997986 SGTC_2994 9053520 71.4286 µM 0.816834173982646 0.212234354764591 no 776 0.207011599882527 1017 4647384 SGTC_42 0133-0086 60.653 µM 0.816474388746234 0.21233745637191 no 777 0.207114432916677 989 162923 Model of phenazepam hydroxylation. SGTC_79 0052-0007 94.094 µM 0.814116534355497 0.213013857368563 no 778 0.207789097310121 1014 2801472 SGTC_2377 9073351 62.6 µM 0.813902747231749 0.213075248879108 no 779 0.20785033337979 975 7337946 YHR072W ERG7 SGTC_2145 5634607 200 µM 0.811765497207761 0.213689552740018 no 780 0.208463101744683 971 308662 SGTC_1680 diphenhydramine 100 µM 0.807315958685059 0.214971775849029 no 781 0.209742235986392 988 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2144 5628481 200 µM 0.807287016392685 0.214980130746463 no 782 0.20975057127007 1021 2818399 SGTC_2280 7785178 200 µM 0.807234285085057 0.214995353407164 no 783 0.209765758211459 981 2954328 SGTC_458 nppb 133 µM 0.806360634323537 0.215247653086608 no 784 0.210017469083245 1016 4549 A chloride channel blocker. SGTC_2667 digitoxin 100 µM 0.805402035630618 0.215524682297521 no 785 0.210293858724421 996 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2971 9092186 9.93 µM 0.805310944617278 0.215551017802441 no 786 0.210320133807585 941 25236400 SGTC_1294 1000-1494 117 µM 0.80317942983954 0.216167796868932 no 787 0.210935516543186 1017 712797 YDL207W GLE1 SGTC_3258 9138477 49.47 µM 0.801814688280137 0.216563237095491 no 788 0.211330080413923 1083 4970355 SGTC_1496 4469-0713 57.4 µM 0.801565793076909 0.216635400736273 no 789 0.211402085717866 1029 746691 SGTC_2171 5739187 198.077 µM 0.795923630591017 0.218274993560438 no 790 0.213038212680661 1014 2262761 SGTC_1843 st055809 45.5 µM 0.79591921941822 0.218276278222663 no 791 0.213039494725846 986 16413835 SGTC_724 3910-0327 137 µM 0.794448851327873 0.218704734983193 no 792 0.213467087234142 1066 2885483 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.792524024227834 0.219266349397417 no 793 0.214027594648577 991 2374 Ca(2+)-ATPase inhibitor. SGTC_2442 5158906 48.48 µM 0.792491944559185 0.219275716426415 no 794 0.21403694346237 1043 1893835 SGTC_613 3914-0030 117 µM 0.79193085661912 0.219439587194572 no 795 0.214200496881494 844 1145395 SGTC_2046 4110841 106 µM 0.788570150828227 0.220422583119757 no 796 0.215181641284444 1073 44119630 YMR134W ERG29 SGTC_3324 9138759 60.749 µM 0.788129378657327 0.220551694550869 no 797 0.215310516151482 1055 45595710 SGTC_2924 9010168 62.78 µM 0.787589418020865 0.220709919407947 no 798 0.215468453193895 1066 2993929 SGTC_1368 1852-0141 284 µM 0.784779258755961 0.221534430284992 no 799 0.21629150148246 1011 2838987 SGTC_1122 capsaicin 818.572 nM 0.784299557872052 0.221675351969293 no 800 0.216432179423628 1063 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2029 5175081 200 µM 0.784208875623811 0.221701997440495 no 801 0.216458779012159 1119 1380876 SGTC_2177 5811945 192 µM 0.783535249463518 0.221899988567743 no 802 0.216656431238354 1082 5343475 SGTC_358 0075-0058 9.45 µM 0.780948521323343 0.222661213263284 no 803 0.217416386271579 1089 1069125 SGTC_1168 k815-0004 80.5 µM 0.779409180640736 0.223114917398496 no 804 0.217869358756503 1068 642433 SGTC_185 k048-0037 25.491 µM 0.778938139689002 0.223253856770607 no 805 0.218008077811876 1106 6827589 SGTC_2735 sertaconazole 140 nM 0.777054864990081 0.223809843793947 no 806 0.218563200712229 1072 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_219 mitoxanthrone 164.414 µM 0.776047612830684 0.224107531078593 no 807 0.218860436821775 1040 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_403 arphamenine a 50 µM 0.774482779475392 0.224570453903959 no 808 0.219322673929202 1056 5487158 An arginine aminopeptidase inhibitor. SGTC_3315 9136395 68.55 µM 0.773645218500907 0.224818451311798 no 809 0.219570311924705 1126 16876844 SGTC_3219 9131112 49.47 µM 0.773088877233379 0.224983266830763 no 810 0.219734891643035 1031 17612988 YMR079W SEC14 SGTC_2565 isoliquiritigenin 100 µM 0.772097043934885 0.225277266205136 no 811 0.220028476452402 986 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_453 enantio-paf c16 10 µM 0.771504461586527 0.225453023333224 no 812 0.220203989451277 1098 13871343 A lipid and platelet activating factor SGTC_75 0159-0059 199.013 µM 0.770428360415424 0.225772388245673 no 813 0.220522917844607 1047 5377270 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.768602896034584 0.226314733683121 no 814 0.221064542881421 1107 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3165 9101544 49.47 µM 0.767183420607282 0.226736967931082 no 815 0.221486234441283 1085 5002184 SGTC_2895 9054447 58.44 µM 0.767163124273893 0.226743008458377 no 816 0.221492267320026 1101 2697450 SGTC_2067 5224629 34.075 µM 0.766617162856979 0.226905529750971 no 817 0.221654584045784 1092 2835000 SGTC_1729 st035615 45.989 µM 0.766099112247494 0.227059803312979 no 818 0.221808665595194 1024 17385451 SGTC_789 1309-1135 70.6 µM 0.764792469145867 0.227449179387359 no 819 0.222197566441602 1119 3092424 SGTC_480 am 92016 50 µM 0.763676469386684 0.227782041852075 no 820 0.222530033309715 1040 2129 K+ channel blocker. SGTC_3334 9142812 21.919 µM 0.760695561112976 0.228672482022296 no 821 0.223419463367971 1057 45283678 SGTC_1936 st074407 74.3 µM 0.760570626908184 0.228709844294414 no 822 0.223456784785253 1147 809813 SGTC_3248 9135562 49.47 µM 0.760559083398901 0.228713296618344 no 823 0.223460233340346 1115 17650701 SGTC_149 3970-0822 46.1 µM 0.755351871313085 0.230273600955819 no 824 0.225018941440898 1173 3114250 YBL034C STU1 SGTC_1968 st069590 43.6 µM 0.754209564789223 0.230616679507483 no 825 0.225361697583949 1073 6384066 SGTC_2533 agelasine 13.65 µM 0.752890750826388 0.231013124997797 no 826 0.225757783288703 1142 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2355 9061122 103.12 µM 0.752157197471264 0.231233801248703 no 827 0.225978265193395 1106 5302957 SGTC_3100 9120536 49.47 µM 0.751510397246867 0.23142847691432 no 828 0.226172772923245 1013 16421196 SGTC_809 3998-0021 90 µM 0.750633889291843 0.231692436406643 no 829 0.226436509964489 1071 715485 SGTC_1084 voriconazole 435 nM 0.750142127356529 0.231840603454136 no 830 0.226584554790884 1140 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3076 9116187 49.47 µM 0.750139372035832 0.231841433776308 no 831 0.226585384433492 1059 27241210 SGTC_1286 0929-0070 131 µM 0.748388325685172 0.232369450487968 no 832 0.227112981075441 1137 1420408 SGTC_2904 7225135 42.03 µM 0.74829128451724 0.232398732175264 no 833 0.227142240172469 1163 4446116 SGTC_1502 4534-4282 27.7 µM 0.747810082748976 0.232543962721051 no 834 0.227287359769373 1077 3278949 SGTC_3009 9080819 71.4286 µM 0.747231654276645 0.232718603831011 no 835 0.22746186987151 1143 17027216 SGTC_2384 9036245 200 µM 0.74628955786316 0.23300320079122 no 836 0.227746258970732 1123 6462766 SGTC_2880 9042983 58.44 µM 0.745823250171783 0.233144138694612 no 837 0.2278870965184 1139 6464714 SGTC_160 3453-0671 289.699 µM 0.745728195500872 0.233172874041681 no 838 0.227915811613943 1136 5322268 SGTC_2686 alizarin 95.37 µM 0.744861357219865 0.233435012867967 no 839 0.22817776897156 1099 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3298 9116858 71.43 µM 0.74309659841579 0.233969194900555 no 840 0.228711599461636 1129 2506942 SGTC_1917 st066507 28.5 µM 0.742326553066982 0.234202495101921 no 841 0.228944753797744 1093 3156428 SGTC_3332 9141069 11.198 µM 0.741686706677243 0.234396446928976 no 842 0.22913858790408 1105 17332883 SGTC_161 4065-0411 162.148 µM 0.741401236398401 0.234483008053754 no 843 0.229225097527049 1107 1906281 YLR208W SEC13 SGTC_2813 7971799 71.43 µM 0.74106190596562 0.234585923811177 no 844 0.229327952884448 1103 2234054 SGTC_1742 st038235 28.8875 µM 0.739814516792063 0.23496445995753 no 845 0.22970627464424 1087 564103 YBR002C RER2 SGTC_52 0329-0193 875 nM 0.738349481871442 0.23540947412516 no 846 0.230151052378189 1161 3739292 SGTC_3059 1327-0034 3 µM 0.737874661254421 0.235553803816602 no 847 0.230295309003219 1104 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_995 3931-2021 34.6 µM 0.736388995132079 0.236005712144194 no 848 0.230746999984652 1104 730143 SGTC_3137 9097352 49.47 µM 0.735304484826572 0.236335898758179 no 849 0.231077038732312 1221 44120435 SGTC_3041 9091929 49.47 µM 0.733624757385114 0.23684780496627 no 850 0.231588733911619 1218 25236887 SGTC_3143 9086658 49.47 µM 0.73262641771737 0.237152343105502 no 851 0.231893156993589 1181 25236626 SGTC_787 4152-0075 138 µM 0.731563548139378 0.237476802043366 no 852 0.232217501937566 1100 9566539 SGTC_833 3852-0053 558 µM 0.731443266901504 0.237513535270099 no 853 0.232254222816389 1175 3123681 SGTC_2041 5107442 45.335 µM 0.729989278867395 0.237957821815137 no 854 0.23269836898571 1150 793005 SGTC_1104 tacrolimus 29.8 µM 0.72933338498035 0.238158388464572 no 855 0.232898877687664 1184 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1904 st060225 78 µM 0.727890494033622 0.23859993782223 no 856 0.233340311339078 1164 66595 SGTC_1324 1418-0026 34.4 µM 0.727741111295356 0.238645677080727 no 857 0.233386039543434 1140 1372513 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.72712604402077 0.238834054073474 no 858 0.23357437285103 1139 6708514 SGTC_61 0978-8327 98.565 µM 0.726478513290352 0.239032461519545 no 859 0.233772737487423 1195 6150059 YHR072W ERG7 SGTC_3348 9149464 3.537 µM 0.72532092278402 0.239387378869351 no 860 0.234127586440335 1162 1951442 SGTC_3115 9123671 49.47 µM 0.722990099440442 0.24010288189676 no 861 0.234842983421824 1248 3286988 SGTC_2192 5915882 198.485 µM 0.722360788590373 0.240296263877578 no 862 0.235036344032011 1111 2876149 SGTC_819 1013-0258 27.7 µM 0.721415982063346 0.240586754323124 no 863 0.235326808193925 1183 5753198 SGTC_3032 9089427 49.47 µM 0.721305465391648 0.24062074629134 no 864 0.235360797542705 1149 17173707 SGTC_1789 tunicamycin 25 nM 0.720936806283368 0.240734154863488 no 865 0.23547419806636 1169 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_652 0437-0092 114 µM 0.720840206246213 0.240763876210172 no 866 0.235503917479496 1142 3091274 SGTC_327 1273-0057 3.96 µM 0.719406159093908 0.241205330393513 no 867 0.235945351528151 1116 3108138 SGTC_1892 st058411 7.36 µM 0.718507077078726 0.241482326208626 no 868 0.236222342912103 1155 3934738 SGTC_3017 9080681 49.47 µM 0.717345406021055 0.241840478065205 no 869 0.236580498397847 1143 16451914 SGTC_68 0986-0284 82.829 µM 0.716161933182834 0.242205647761506 no 870 0.236945682642202 1090 423278 YIL048W NEO1 SGTC_2032 5185112 25.99 µM 0.715840757779692 0.242304800455248 no 871 0.237044841174179 1100 5718189 SGTC_1667 st014849 34.6 µM 0.713245540648939 0.243106797630726 no 872 0.237846915146348 1207 5348460 SGTC_1802 st050112 57.9 µM 0.711543776960118 0.243633470075 no 873 0.238373666587538 1180 4662563 SGTC_3077 9117319 49.47 µM 0.710906934165218 0.243830722468068 no 874 0.238570954380479 1201 17154678 SGTC_634 1611-4317 11.2 µM 0.710782383000362 0.243869310375966 no 875 0.238609549583564 1198 2843522 SGTC_450 aminopyrene 156 nM 0.710355541003318 0.244001577728972 no 876 0.23874184286044 1147 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1280 0880-0253 10.1 µM 0.710217932981818 0.244044227162056 no 877 0.238784500955652 1158 6836607 SGTC_2334 9017922 200 µM 0.709976337856544 0.244119115481722 no 878 0.238859404842555 1183 3163164 SGTC_740 k014-0057 261 µM 0.709030850256264 0.244412311610151 no 879 0.239152666296927 1187 4012779 SGTC_2484 5809818 12.04 µM 0.707950216106027 0.244747648981531 no 880 0.23948808692443 1167 2870548 SGTC_2920 7982904 15.77 µM 0.707047334345489 0.245028016875165 no 881 0.239768531410708 1144 6456808 SGTC_2999 9069765 71.4286 µM 0.704780441535976 0.245732705907466 no 882 0.240473440975155 1189 2097066 SGTC_600 1495-0418 41.6 µM 0.704269059439028 0.245891825052922 no 883 0.240632615454288 1187 5377768 SGTC_1895 st058434 18.3 µM 0.704034091821098 0.245964954961249 no 884 0.240705771476686 1194 5393175 SGTC_782 0083-0095 30.5 µM 0.702822845936118 0.246342120913498 no 885 0.241083078935752 1206 3591729 An indicator and reagent. SGTC_1106 tegaserod maleate 11.7 µM 0.702725736696014 0.24637237286459 no 886 0.241113342731727 1195 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1388 3346-4487 254 µM 0.70225479371492 0.246519111592269 no 887 0.241260139955328 1225 3345614 SGTC_1470 k295-0292 231 µM 0.702146654734897 0.246552812676088 no 888 0.241293854717561 1206 5045612 SGTC_504 lovastatin 124 µM 0.698396725178481 0.247722988570643 no 889 0.242464561908807 1159 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_517 1365-0151 113 µM 0.697661455128177 0.247952778888626 no 890 0.242694469395677 1229 768657 SGTC_1967 st070177 51.4 µM 0.697094017549076 0.248130195090508 no 891 0.242871978936195 1219 5729214 SGTC_2914 7968218 45.32 µM 0.695969251960748 0.248482066650042 no 892 0.243224043017273 1125 2977111 SGTC_2407 paclitaxel 400 µM 0.695959036484172 0.248485263676756 no 893 0.24322724183827 1210 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2915 7971052 15.16 µM 0.694385574056287 0.24897795470319 no 894 0.243720219067425 1085 5741558 SGTC_2505 galangin 7.89 µM 0.693594622964456 0.249225817764898 no 895 0.243968233380848 1113 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2504 purpurogallin 52.29 µM 0.693233129702847 0.249339143825207 no 896 0.244081630213865 1139 5281571 An antioxidant. SGTC_2800 7887935 81.82 µM 0.691736863012673 0.249808506043506 no 897 0.244551296350468 1179 2961002 SGTC_911 3456-4043 236 µM 0.691164797582019 0.249988080483719 no 898 0.244730991662987 1244 914281 SGTC_1971 st069429 63.5 µM 0.691145017636354 0.249994290740854 no 899 0.24473720614572 1192 1246522 YGL099W LSG1 SGTC_2248 tofa 1.1 µM 0.691110692620011 0.25000506786959 no 900 0.244747990614666 1146 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3023 9089636 49.47 µM 0.689355511383504 0.250556475849652 no 901 0.245299786348986 1289 17249241 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.68847888888317 0.250832116775248 no 902 0.245575630062801 1243 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1712 st032288 53.4 µM 0.688284665409522 0.250893209178635 no 903 0.245636768218606 1212 2883011 SGTC_1050 3232-1156 69.3 µM 0.687921232224196 0.251007547136446 no 904 0.245751192590881 1168 700529 SGTC_1522 st012842 45.6 µM 0.687270634047593 0.251212297520986 no 905 0.245956100280925 1129 3491067 YOR116C RPO31 SGTC_3281 9140613 49.47 µM 0.684730572319657 0.252012527635942 no 906 0.246756976636637 1158 16013766 SGTC_1674 st016616 23.6 µM 0.684439689471608 0.252104254165582 no 907 0.246848780434359 1207 625830 SGTC_977 1348-1378 135 µM 0.684360447584027 0.252129245227032 no 908 0.246873792661285 1216 X977 SGTC_2946 9065502 71.43 µM 0.683086977769904 0.252531047376222 no 909 0.247275941780931 1047 16489101 SGTC_479 n-linoleoylglycine 10 µM 0.682745378851019 0.252638885208056 no 910 0.247383874871995 1212 6433346 An anti-infammatory. SGTC_3096 9117468 49.47 µM 0.681576745713659 0.253007989114539 no 911 0.247753311665084 1125 41316311 SGTC_1884 5633444 25 µM 0.680150672889633 0.253458787482722 no 912 0.248204530929139 1227 5724239 SGTC_1296 1068-0102 11.9 µM 0.679070398314632 0.253800555724513 no 913 0.248546628750829 1187 767053 SGTC_840 0245-0196 390 µM 0.6785450792289 0.253966839175145 no 914 0.248713075818635 1276 3827528 SGTC_1255 0566-0045 221 µM 0.677538245256102 0.25428570009574 no 915 0.249032256455454 1242 2788469 SGTC_522 1273-0010 11.6 µM 0.674490759476595 0.255252106113748 no 916 0.249999679274407 1284 5705015 SGTC_608 k048-0125 159 µM 0.673897605563145 0.255440427612224 no 917 0.250188207263054 1251 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2543 pimpinellin 60.67 µM 0.673337073213798 0.255618458731462 no 918 0.250366436087569 1168 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2790 5423970 71.43 µM 0.672504949982718 0.25588286950317 no 919 0.250631144966281 1250 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2427 5545055 42.75 µM 0.671248145475048 0.256282495023459 no 920 0.25103123117935 1247 5372858 SGTC_2346 9031566 143.75 µM 0.669313582955847 0.256898262142343 no 921 0.251647732000207 1199 4771086 SGTC_173 1273-0061 2.693 µM 0.669288677806295 0.256906194414573 no 922 0.251655673912241 1195 2847414 YPL266W DIM1 SGTC_1463 k081-0032 34.1 µM 0.668748475111603 0.257078279941274 no 923 0.2518279697458 1097 977755 SGTC_825 1988-2224 89.6 µM 0.6604910152991 0.259716197117134 no 924 0.254469391166795 1260 1180859 SGTC_1222 0366-0074 1.18 µM 0.65967861408207 0.259976478512297 no 925 0.254730046715191 1279 286520 SGTC_2133 5320837 200 µM 0.657910762642845 0.260543336616219 no 926 0.255297737220084 1250 2841355 SGTC_1350 1495-0454 146 µM 0.656977992383502 0.260842683829745 no 927 0.255597533693755 1281 1069057 SGTC_1731 st035964 63 µM 0.656871873206345 0.260876751095278 no 928 0.255631652511026 1265 6739575 SGTC_2434 5670830 169.91 µM 0.656215584398593 0.261087489246382 no 929 0.255842711480466 1247 1549830 SGTC_404 fumagillin 50 µM 0.655926810076795 0.261180244075332 no 930 0.255935608563517 1253 12015870 A methionine aminopeptidase binder. SGTC_1325 1431-0015 227 µM 0.653667382769337 0.261906560305357 no 931 0.256663060829351 1206 1103340 SGTC_1780 st038448 24.544 µM 0.653617197057612 0.261922704770906 no 932 0.256679230991549 1325 728868 YDL195W SEC31 SGTC_118 0083-0097 135.343 µM 0.653442137582283 0.261979024429059 no 933 0.256735640443274 1331 5207356 SGTC_2536 dehydroabietamide 32.04 µM 0.65257093781572 0.26225939675116 no 934 0.257016463276341 1299 3983547 SGTC_2622 2-methoxyxanthone 59.94 µM 0.650915701373549 0.262792513411746 no 935 0.257550452611302 1294 71034 A hepatoprotective. SGTC_1886 st057356 49.9 µM 0.649923034295704 0.26311249615312 no 936 0.25787096922277 1227 24207747 SGTC_2756 carbadox 75.1 µM 0.648577553382838 0.263546524762596 no 937 0.2583057340402 1275 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_288 1315-0019 35.1 µM 0.645612328526344 0.264504342616095 no 938 0.259265225551135 1306 6811474 SGTC_182 3448-4371 550.524 µM 0.645378672651137 0.26457989264002 no 939 0.259340910450381 1303 3491403 SGTC_2366 9070441 60.58 µM 0.645223106761851 0.264630199224044 no 940 0.259391307075669 1264 6837235 SGTC_1513 0337-0559 19 µM 0.645172284544798 0.264646635064569 no 941 0.259407772374021 1211 775073 SGTC_1451 4152-0210 104 µM 0.643768849392847 0.265100709254454 no 942 0.259862668206521 1291 659563 SGTC_1529 apigenin 74 µM 0.641076362136942 0.265972956067039 no 943 0.260736535532361 1363 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3349 9149703 23.001 µM 0.640508118934678 0.266157227363812 no 944 0.260921156262095 1258 4910494 SGTC_2900 5328528 85.29 µM 0.639701580774233 0.26641888447141 no 945 0.261183313784579 1282 795359 SGTC_1191 1487-1166 10.6 µM 0.638457642085605 0.266822698039663 no 946 0.26158790938072 1347 3955771 SGTC_1690 st023502 41.2 µM 0.638251365121449 0.266889690577354 no 947 0.261655032798518 1268 24207482 SGTC_2391 6285546 200 µM 0.637462021549937 0.267146124015279 no 948 0.261911970217336 1251 846083 SGTC_1331 1472-0049 76.2 µM 0.637419954034546 0.267159793946718 no 949 0.261925667148392 1255 24051409 SGTC_1770 st043884 66.3 µM 0.637388143250795 0.267170131165152 no 950 0.261936024792934 1280 670149 SGTC_1183 1254-0324 198 µM 0.636008035720694 0.267618804607318 no 951 0.262385592237644 1317 5799357 SGTC_2986 9022445 71.43 µM 0.635771628091462 0.267695698895913 no 952 0.262462641199175 1260 6459286 SGTC_2982 9019404 25.97 µM 0.635768157035985 0.26769682797939 no 953 0.26246377255698 1158 22333232 SGTC_1192 1488-0095 21.4 µM 0.634206530630022 0.26820504546753 no 954 0.2629730230727 1290 915875 SGTC_942 3253-1115 227 µM 0.631991297827406 0.268926805214099 no 955 0.263696281796987 1354 46497897 SGTC_2331 7980721 200 µM 0.631503384773433 0.26908590636021 no 956 0.263855718393809 1283 2981221 SGTC_2861 9024595 19.48 µM 0.631390182379658 0.269122826716694 no 957 0.263892716852626 1244 16482810 SGTC_1925 st057770 10.1 µM 0.630342634835659 0.269464599301545 no 958 0.264235217060745 1223 5989122 SGTC_930 2810-3379 265 µM 0.629742350563285 0.269660545895346 no 959 0.26443158458296 1418 1015764 SGTC_2963 9082507 9 µM 0.626722922365412 0.27064723790066 no 960 0.265420437763414 1315 16459611 SGTC_2860 9025725 38.96 µM 0.626595125147126 0.270689039351573 no 961 0.265462332302063 1259 40546248 SGTC_2705 st078069 42.8 µM 0.624833661828687 0.271265528203382 no 962 0.266040117581354 1283 1530061 SGTC_2753 fluvastatin 17.09 µM 0.623892482970924 0.271573806347419 no 963 0.266349098651921 1330 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1670 st016595 4.04 µM 0.623839189436638 0.271591267579677 no 964 0.266366599899906 1296 597879 SGTC_2371 9071574 200 µM 0.623585174887059 0.27167450124946 no 965 0.26645002461164 1281 45596039 SGTC_1804 st050076 49.1 µM 0.622854967257504 0.271913841158782 no 966 0.266689916592545 1325 3895976 SGTC_2118 5526350 200 µM 0.622844472524934 0.271917281778184 no 967 0.266693365177716 1330 743594 SGTC_278 4092-0821 23.9 µM 0.621840388965226 0.272246563166463 no 968 0.267023412786828 1313 877900 SGTC_1407 3909-7909 12.3 µM 0.621825135435779 0.272251566970289 no 969 0.267028428293212 1298 4411780 SGTC_2451 5856223 45.7 µM 0.621390111328585 0.272394292540716 no 970 0.267171488403217 1282 2179896 SGTC_2879 9041815 71.43 µM 0.620951204898857 0.272538329503049 no 971 0.26731586443313 1261 4942971 SGTC_3015 9080845 49.47 µM 0.618783073657833 0.273250404558928 no 972 0.268029637163784 1368 5296973 SGTC_3111 9122088 49.47 µM 0.616835388577903 0.27389086378348 no 973 0.268671653695625 1230 16876704 SGTC_1115 galangin 695.678 nM 0.616316947806809 0.274061468156639 no 974 0.268842677741224 1353 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2777 climbazole 1.536 µM 0.615759932700145 0.274244824761038 no 975 0.269026487653817 1306 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1992 st073643 23.3 µM 0.615647537300352 0.274281830093947 no 976 0.26906358475871 1305 3161292 SGTC_1040 k898-0338 155 µM 0.615362781356285 0.274375594863521 no 977 0.26915758248945 1381 20969351 SGTC_1745 st081495 74 µM 0.615052069546098 0.274477924459497 no 978 0.26926016702578 1280 13842402 YBL026W LSM2 SGTC_2825 7998094 58.44 µM 0.614048537271063 0.274808555615368 no 979 0.269591626891361 1316 2987815 SGTC_2183 6420625 130.508 µM 0.613486390407048 0.274993850425788 no 980 0.269777389460519 1303 2897619 SGTC_914 3820-6779 408 µM 0.613294307489968 0.275057178890017 no 981 0.269840878338734 1296 2893481 SGTC_3117 9124945 49.47 µM 0.612808743724815 0.275217298068548 no 982 0.270001404349837 1230 17592065 SGTC_2363 9053361 176 µM 0.61062409891466 0.275938272237786 no 983 0.270724232416422 1403 6469797 YMR079W SEC14 SGTC_2078 5212016 200 µM 0.60942535133136 0.276334275444228 no 984 0.271121269210524 1281 1899708 SGTC_519 k048-0011 62.8 µM 0.607427480380052 0.276994885906593 no 985 0.271783627994238 1341 6836379 SGTC_676 falcarinol 140 µM 0.60716711403332 0.27708103482739 no 986 0.271870007126905 1416 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_680 0417-1641 114 µM 0.604937351719477 0.277819345719964 no 987 0.272610311898036 1316 2835990 SGTC_2903 5923464 63.88 µM 0.60442696150907 0.277988479287558 no 988 0.272779907494073 1357 2876576 SGTC_233 rapamycin 362 pM 0.601668670888581 0.278903392629722 no 989 0.273697354076275 1349 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1932 st074806 40.9 µM 0.601069919353112 0.279102189336328 no 990 0.273896708777413 1427 17251235 SGTC_2433 5607874 27.82 µM 0.599630624412236 0.279580343842937 no 991 0.274376216421215 1321 2252428 SGTC_1029 k015-0030 64.7 µM 0.59787623827607 0.280163713441725 no 992 0.274961257955508 1384 2208316 SGTC_1381 2324-0066 62.1 µM 0.595602117595926 0.280920782180023 no 993 0.275720530842171 1355 10885928 SGTC_2840 9008771 71.43 µM 0.595497097797025 0.280955767788579 no 994 0.275755619245705 1338 2992978 SGTC_1515 3460-0031 42.1 µM 0.595177241481233 0.281062335599842 no 995 0.275862500684671 1306 2876596 SGTC_3208 9114115 49.47 µM 0.593373827354047 0.281663551493054 no 996 0.276465500299767 1295 650895 SGTC_777 1315-0167 517 µM 0.592127444662722 0.282079428246906 no 997 0.27688262514025 1307 4221767 SGTC_2420 aureobasidin a 50 nM 0.591013561960201 0.282451344141564 no 998 0.277255667032117 1479 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_166 k072-0058 166.424 µM 0.588154255487527 0.283407120272776 no 999 0.278214379336245 1343 5846229 SGTC_2155 5570423 76 µM 0.587100749829114 0.283759664509833 no 1000 0.278568022007415 1341 797402 SGTC_3104 9120930 49.47 µM 0.58626541134245 0.284039350652335 no 1001 0.27884858546936 1350 17014836 SGTC_901 1112-0062 60.1 µM 0.584876272532833 0.284504750761932 no 1002 0.279315456979623 1371 1908457 SGTC_1691 st019933 84.6 µM 0.583768970446517 0.284875988428621 no 1003 0.279687878656766 1358 6176082 SGTC_1631 benzylvanillin 81.9 µM 0.582375292015875 0.285343565762232 no 1004 0.280156960257436 1392 75506 SGTC_3163 9099914 49.47 µM 0.580460340627811 0.285986625075236 no 1005 0.280802111996541 1396 16268368 SGTC_115 0527-0192 112.043 µM 0.580003330482882 0.286140195274587 no 1006 0.280956185927618 1382 4233931 SGTC_2919 7978188 46.38 µM 0.579092666459287 0.286446324608592 no 1007 0.281263324042568 1371 2980291 SGTC_1972 st070201 17.4 µM 0.578905371081299 0.286509305193482 no 1008 0.281326512930767 1381 2829099 SGTC_273 hydroxyurea 18.1 mM 0.577494812760742 0.286983835292738 no 1009 0.281802620881361 1403 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3166 9102297 49.47 µM 0.57566466644886 0.287600074524075 no 1010 0.282420931203034 1318 25237072 SGTC_707 0865-0008 204 µM 0.573765951377782 0.288240062260871 no 1011 0.283063096139478 1433 723043 SGTC_145 3737-0113 38.366 µM 0.572704748144985 0.288598047627661 no 1012 0.283422311005052 1371 6849351 SGTC_1983 st071813 46.9 µM 0.572222863317764 0.288760675352205 no 1013 0.283585500030408 1370 11838595 SGTC_770 0389-1121 67.2 µM 0.571689033973314 0.288940883804277 no 1014 0.283766332471633 1477 6753108 SGTC_971 1315-0384 26.7 µM 0.57154558789061 0.288989316906194 no 1015 0.283814933637781 1370 6769120 SGTC_71 0417-1750 47.813 µM 0.571348495528497 0.289055869353805 no 1016 0.283881717272885 1488 6811472 SGTC_2537 larixol 68.93 µM 0.567760945563123 0.290268540215782 no 1017 0.285098650959451 1373 6708759 SGTC_2594 a-mangostin 100 µM 0.566783519425239 0.290599344351876 no 1018 0.285430634461035 1450 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1237 0330-0133 46.1 µM 0.565355125869633 0.291083092736631 no 1019 0.285916120180925 1366 X1237 YHR072W ERG7 SGTC_426 0988-0037 14.6 µM 0.562601102318818 0.29201684714537 no 1020 0.286853270621985 1402 5383008 SGTC_871 0574-0004 149 µM 0.562600182789214 0.292017159145545 no 1021 0.28685358376624 1402 9551173 SGTC_275 trichlorophene 5.69 µM 0.561932818594698 0.292243639478962 no 1022 0.287080896229444 1434 62616 SGTC_508 roscovitine 141 µM 0.561588552183601 0.292360503535057 no 1023 0.287198190949003 1449 160355 A CDKinase inhibitor. SGTC_1743 st037606 46.3785 µM 0.559925488460978 0.292925349957032 no 1024 0.287765131225772 1433 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1433 4060-0023 7.6 µM 0.559713998313183 0.292997217193168 no 1025 0.287837266329967 1419 3840627 SGTC_1240 0356-0016 42.1 µM 0.559343680510347 0.293123075931481 no 1026 0.287963594969971 1429 4305613 SGTC_2321 7390090 138.78 µM 0.557987749178704 0.293584125851046 no 1027 0.288426374864129 1335 649046 SGTC_1730 st033808 45.1 µM 0.55794704191383 0.29359797250979 no 1028 0.288440273688155 1449 1045166 SGTC_3216 9129716 49.47 µM 0.556294523654318 0.2941603350443 no 1029 0.289004765131939 1344 8056934 SGTC_2088 5278280 127.392 µM 0.555935192062438 0.294282683732728 no 1030 0.289127579647296 1407 791502 SGTC_1610 st001799 48.1 µM 0.555039946432572 0.294587607782672 no 1031 0.289433668782579 1353 621897 SGTC_307 1501-1223 22.3 µM 0.554753726654812 0.294685126065415 no 1032 0.289531560915134 1391 2830329 SGTC_1751 st044839 27.194 µM 0.554677615549886 0.29471106047678 no 1033 0.289557594850891 1414 5291326 SGTC_1003 4049-0218 100 µM 0.553607145522174 0.295075928298369 no 1034 0.289923867373638 1467 295161 SGTC_2252 omeprazole 400 µM 0.552847629462502 0.295334934117779 no 1035 0.29018387543762 1392 4594 A proton pump inhibitor. SGTC_549 1661-1316 519 µM 0.552361647032674 0.295500715928709 no 1036 0.290350300975173 1475 2857282 SGTC_2620 irigenin 100 µM 0.552123774045313 0.295581876464758 no 1037 0.290431777286885 1500 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1383 3049-0032 20.7 µM 0.551221046408997 0.29588997378202 no 1038 0.290741077109467 1483 712864 SGTC_48 0382-0018 55 µM 0.55086962066215 0.296009953847553 no 1039 0.290861527072941 1508 762596 SGTC_2455 5377712 9.75 µM 0.548257084289583 0.296902597697327 no 1040 0.29175769529913 1362 2243908 SGTC_558 k064-0027 21.3 µM 0.547550692280113 0.297144167048611 no 1041 0.292000227006641 1484 5088526 SGTC_89 0302-0250 142.109 µM 0.546851545737659 0.297383347063344 no 1042 0.292240363452528 1469 4203518 YLR208W SEC13 SGTC_2560 caryophyllene 100 µM 0.544761010040867 0.29809904931759 no 1043 0.292958948968676 1430 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_677 0929-0063 136 µM 0.543401809459368 0.298564796991193 no 1044 0.293426590068301 1391 1539583 SGTC_389 tpck 16.7 µM 0.542845862090385 0.298755394883046 no 1045 0.293617966691725 1411 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1676 st018489 23.4 µM 0.542393571101646 0.298910496586144 no 1046 0.293773703761552 1439 3696235 SGTC_101 0490-5701 117.494 µM 0.541309602695757 0.299282364809463 no 1047 0.294147101396335 1393 4661669 SGTC_2770 toltrazuril 17.5 µM 0.541046136697937 0.299372781641732 no 1048 0.294237891386635 1411 68591 Kills coccidiodes. SGTC_3048 9093155 49.47 µM 0.536287931174362 0.30100784035917 no 1049 0.29587978516208 1402 25236002 SGTC_2443 5493264 126.67 µM 0.535988368302399 0.301110913504495 no 1050 0.295983294696135 1506 5340055 SGTC_1489 4065-0444 182 µM 0.535373522523565 0.301322518527806 no 1051 0.296195797649862 1480 2877968 SGTC_3190 9110366 49.47 µM 0.534912680028553 0.301481165743866 no 1052 0.296355119873659 1450 17123768 SGTC_2247 cerulenin 830 nM 0.534409804286519 0.301654325979203 no 1053 0.29652901862538 1482 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2736 butenafine 14.65 µM 0.533678729939038 0.301906143869072 no 1054 0.296781913774476 1462 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1144 3486-0183 12.5 µM 0.533430380133289 0.30199170921979 no 1055 0.296867846050054 1423 6744069 SGTC_831 k061-1017 217 µM 0.532930068470037 0.302164117467378 no 1056 0.297040994984047 1520 1240153 SGTC_501 nsc-95397 161 µM 0.53147039662544 0.302667375158184 no 1057 0.297546425101686 1496 262093 SGTC_1074 carmofur 3.8 µM 0.528919484073331 0.303547765179121 no 1058 0.298430652592607 1454 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2616 abietic acid 100 µM 0.528899584074094 0.303554637709314 no 1059 0.29843755526412 1464 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2246 7293507 91.5585 µM 0.524381734477651 0.305116686624683 no 1060 0.300006529084161 1562 887656 SGTC_635 k038-0028 24.7 µM 0.52336605050364 0.305468350622814 no 1061 0.300359772378472 1500 4035102 SGTC_3224 9130643 49.47 µM 0.523045726855433 0.305579294718928 no 1062 0.30047121625872 1491 17644395 SGTC_1108 betulinic acid 729.144 nM 0.522940628733382 0.305615699343896 no 1063 0.300507785041391 1441 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2940 9060638 45.86 µM 0.522852241192936 0.30564631712797 no 1064 0.300538540950448 1477 4027022 SGTC_639 0833-0042 114 µM 0.520380443934858 0.306503106974963 no 1065 0.301399218800868 1418 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_492 tmb-8 126 µM 0.519860533462057 0.306683456525553 no 1066 0.301580392353514 1388 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2775 cyproheptadine 69.59 µM 0.517792743866806 0.307401206358927 no 1067 0.302301440767521 1462 2913 A selective serotonin reuptake inhibitor. SGTC_1258 0671-0043 57.1 µM 0.515859582287905 0.308072893318267 no 1068 0.30297624240459 1432 4298767 SGTC_3075 9116269 49.47 µM 0.515510046740803 0.308194409991441 no 1069 0.303098325425681 1496 17015205 YNL244C SUI1 SGTC_2980 9014342 25.29 µM 0.515094174975834 0.308339015961288 no 1070 0.303243606496308 1454 2996599 SGTC_2950 9072895 21.46 µM 0.512328239608198 0.309301536553916 no 1071 0.304210652216834 1408 17332245 SGTC_197 4544-0043 41.561 µM 0.510967425859765 0.309775568758789 no 1072 0.304686933114676 1458 896523 SGTC_1102 cgs 12066b 26.1 µM 0.510494362170811 0.309940432149173 no 1073 0.304852581679571 1462 6438352 A 5-HT1B full agonist. SGTC_1016 4226-1401 38 µM 0.51026105861679 0.310021752857015 no 1074 0.304934290272593 1454 2901613 SGTC_1579 chlormadinone acetate 49.4 µM 0.50743292240119 0.311008271368479 no 1075 0.305925545238386 1555 45114258 A steroidal progestin. SGTC_2867 9039098 71.43 µM 0.506974085699279 0.31116845245995 no 1076 0.306086500772389 1443 6463460 SGTC_826 1683-5028 118 µM 0.506287340862092 0.311408263704541 no 1077 0.306327474260492 1491 722377 SGTC_1827 berberine 7.24 µM 0.503424550939615 0.312408811139387 no 1078 0.307332907060927 1359 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1046 2001-0062 216 µM 0.502974053106152 0.312566386777842 no 1079 0.307491257407171 1463 739778 SGTC_1482 3346-2049 8.48 µM 0.501762143712147 0.312990459853322 no 1080 0.307917422568723 1509 3826804 SGTC_2399 5884133 200 µM 0.501400929379051 0.313116904402346 no 1081 0.308044492928426 1460 722445 SGTC_2052 5265182 7.135 µM 0.500219614725726 0.313530581832175 no 1082 0.308460224241361 1574 1239884 SGTC_1750 st081859 2.357 µM 0.499614112029284 0.313742710149381 no 1083 0.308673409604432 1508 5291695 SGTC_1397 3532-0190 20.1 µM 0.499038163313431 0.313944541853519 no 1084 0.308876249460693 1488 5322280 SGTC_2300 7976697 71.57 µM 0.498648871113767 0.314080994405839 no 1085 0.309013384928353 1413 2236109 SGTC_2139 5578692 56.4705 µM 0.498530964257992 0.31412232748232 no 1086 0.309054925079967 1528 650991 YMR113W FOL3 SGTC_2390 9097792 176.6 µM 0.497197574911478 0.314589918654683 no 1087 0.30952486570455 1429 4497149 SGTC_1087 pterostilbene 9.05 µM 0.495629181755814 0.315140301443379 no 1088 0.310078030065891 1591 5281727 Similar to reservatol, lowers cholesterol. SGTC_1626 st003712 1.76 µM 0.494615529144799 0.315496232422939 no 1089 0.310435769145873 1524 24207035 SGTC_468 gf-109203x 121 µM 0.491841881116591 0.316471037647283 no 1090 0.31141556345096 1489 2396 A protein kinase C inhibitor. SGTC_3291 9121177 71.43 µM 0.49143935317055 0.316612613272562 no 1091 0.311557868180233 1465 17015612 SGTC_2601 securinine 100 µM 0.491195483762034 0.316698399182377 no 1092 0.311644096437381 1467 442872 A GABA receptor antagonist. SGTC_2302 7771753 200 µM 0.489855077663854 0.317170089577927 no 1093 0.312118226553124 1428 2203047 SGTC_726 3448-4391 34.2 µM 0.48906627352543 0.317447809587913 no 1094 0.312397388933311 1605 1356692 SGTC_3120 9124077 49.47 µM 0.487160322246438 0.318119275733946 no 1095 0.313072360507507 1506 18774327 YGL155W CDC43 SGTC_3297 9117502 71.43 µM 0.486563421375521 0.318329686874883 no 1096 0.313283875370158 1495 7453720 SGTC_27 0485-0001 32.618 µM 0.485783871462539 0.318604571170399 no 1097 0.313560205357738 1480 2054479 SGTC_2284 7945075 39.21 µM 0.485473033270114 0.318714206553331 no 1098 0.313670418534624 1618 1245402 SGTC_2976 9009005 19.48 µM 0.48526212077743 0.318788606295128 no 1099 0.313745210760227 1660 2993148 SGTC_3313 9133968 57.047 µM 0.485198615014662 0.318811009492194 no 1100 0.313767732202961 1475 1494643 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.484020877000376 0.319226605053676 no 1101 0.314185526442051 1506 165521 SGTC_2292 7671323 168.05 µM 0.483544718932698 0.319394694388427 no 1102 0.314354507805909 1493 937504 SGTC_1838 st055369 84.5 µM 0.48297358472469 0.31959636037138 no 1103 0.314557246103882 1472 676036 SGTC_1861 st057647 17.4 µM 0.481302918525114 0.320186574348918 no 1104 0.315150611551562 1617 688668 SGTC_1203 3992-3522 103 µM 0.479487568419684 0.32082841848186 no 1105 0.315795905011419 1736 5322312 SGTC_496 calpeptin 138 µM 0.479143896709581 0.320949989134886 no 1106 0.315918131592949 1454 73364 A calpain inhibitor. SGTC_739 1486-1183 203 µM 0.476749702996693 0.321797444912932 no 1107 0.316770182699808 1581 4346692 SGTC_38 0929-0051 58.268 µM 0.476596738553214 0.321851620232293 no 1108 0.316824653146125 1622 1379719 SGTC_1788 fluconazole 20 µM 0.47410690928772 0.322733973299029 no 1109 0.317711835909419 1484 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_759 3486-0358 89.3 µM 0.469459233116173 0.324383700672259 no 1110 0.319370708949966 1679 875103 SGTC_1713 st033146 12.748 µM 0.469275461912229 0.324449002804232 no 1111 0.319436376187884 1641 674619 SGTC_3243 9134147 49.47 µM 0.46693542962176 0.32528099244093 no 1112 0.320273038000726 1576 24282180 SGTC_984 1492-0255 2.91 µM 0.466751999385266 0.325346247262035 no 1113 0.320338660876513 1563 1585198 SGTC_2921 7974240 10.71 µM 0.466057275196649 0.325593442089012 no 1114 0.320587252062563 1585 2979074 YDR527W RBA50 SGTC_2669 eugenol 100 µM 0.463993345517923 0.326328276001676 no 1115 0.321326256639011 1578 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_250 brefeldin a 552.239 µM 0.462408334621983 0.326893055620145 no 1116 0.321894261760935 1470 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2937 9044753 11.33 µM 0.461387562264016 0.327256992870389 no 1117 0.322260286677337 1485 6465530 YGL099W LSG1 SGTC_1705 st027868 56.3335 µM 0.460230295566331 0.327669793317023 no 1118 0.322675463785948 1633 292948 SGTC_2733 amorolfine 100 µM 0.459045887813321 0.328092493261389 no 1119 0.323100606952711 1606 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1865 st057639 52.2 µM 0.457196866913986 0.328752825298832 no 1120 0.323764775059569 1537 688818 SGTC_3098 9119039 49.47 µM 0.457054017112007 0.328803862857285 no 1121 0.323816110090008 1533 17161528 SGTC_2298 7976326 193.81 µM 0.455629043050904 0.329313154041468 no 1122 0.32432837735643 1504 2235818 SGTC_1885 st057546 99.9 µM 0.454383014419408 0.329758749172858 no 1123 0.324776587794614 1609 702008 SGTC_1075 aripiprazole 15.2 µM 0.452933447416328 0.330277436306939 no 1124 0.32529833264409 1532 60795 An atypical antipschotic. YIL048W NEO1 SGTC_236 1509-0011 5.31 µM 0.451384892115766 0.330831904142635 no 1125 0.32585608504672 1567 3107280 SGTC_1312 1218-2183 165 µM 0.450650673220015 0.331094924674112 no 1126 0.326120669405175 1561 6744073 SGTC_2264 7948757 110.76 µM 0.448216538436623 0.331967504840431 no 1127 0.326998464012679 1510 2971411 SGTC_1796 st049173 110.4 µM 0.442873209477829 0.333886156373611 no 1128 0.328928723137028 1596 94134 SGTC_1053 3366-3204 134 µM 0.442790151556339 0.333916014796677 no 1129 0.328958763734972 1528 3632071 YPR165W RHO1 SGTC_136 0097-0015 404.482 µM 0.442780133485934 0.333919616255535 no 1130 0.328962387170542 1589 4861337 SGTC_1567 st069303 68.4 µM 0.441385121610984 0.334421267053169 no 1131 0.329467105789343 1550 5581319 SGTC_412 gemfibrozil 100 µM 0.440231578548992 0.334836308374534 no 1132 0.329884695263165 1574 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_99 0109-0120 622.8 µM 0.43931866437158 0.335164915249115 no 1133 0.330215326026993 1658 759414 SGTC_1754 st042065 16.137 µM 0.439156524104567 0.335223291448767 no 1134 0.330274062356704 1514 1126236 YIL048W NEO1 SGTC_801 0866-0028 10.1 µM 0.43778526956417 0.335717150347719 no 1135 0.330770975059587 1582 6849771 SGTC_3060 1327-0027 12.5 µM 0.437556729852159 0.3357994868089 no 1136 0.330853821891361 1649 16000455 YPR107C YTH1 SGTC_2006 4011487 200 µM 0.437164280254426 0.335940893801882 no 1137 0.330996106234439 1694 45595294 SGTC_315 k915-0449 187 µM 0.435563712738936 0.336517848814869 no 1138 0.33157665172016 1636 20970215 YNL149C PGA2 SGTC_1425 4048-4433 7.33 µM 0.434141733799787 0.337030751299959 no 1139 0.332092760600966 1629 23734946 SGTC_3134 9127454 49.47 µM 0.431695489549721 0.337913811350216 no 1140 0.33298137302343 1622 24262820 SGTC_2650 prasterone 100 µM 0.431665029316321 0.337924812707049 no 1141 0.332992443807289 1572 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_912 3474-0017 2.18 µM 0.431532504043723 0.337972678620493 no 1142 0.333040611864231 1677 3360550 SGTC_2508 celastrol 40.54 µM 0.430366623300364 0.338393888090385 no 1143 0.333464485228193 1517 122724 Celastrol is a natural product and antioxidant. SGTC_2829 7992743 58.44 µM 0.430180603289439 0.338461112138165 no 1144 0.333532135273748 1751 16462845 SGTC_753 1322-0200 289 µM 0.430028462380165 0.338516096758659 no 1145 0.333587468504043 1585 5403907 SGTC_3112 9123419 49.47 µM 0.42880979295157 0.338956655214935 no 1146 0.334030825778213 1601 17015854 SGTC_1483 3453-0561 55.9 µM 0.427258469976533 0.339517789243337 no 1147 0.334595539070001 1625 4546991 SGTC_413 propylparaben 100 µM 0.426913655584094 0.339642561563832 no 1148 0.334721109461474 1554 7175 A pharmaceutical preservative. SGTC_1399 3562-5772 25 µM 0.425198198346966 0.340263566888704 no 1149 0.335346098727119 1549 23847490 SGTC_2801 7907800 81.82 µM 0.422360867858515 0.341291647562263 no 1150 0.336380818135069 1584 6620925 SGTC_668 1682-0499 62.6 µM 0.42207739318844 0.341394426915373 no 1151 0.336484264135228 1586 682214 SGTC_1420 4'-methoxyflavone 42 µM 0.41804931736778 0.342856153649463 no 1152 0.337955529903131 1694 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3342 9147791 14.508 µM 0.418017388158647 0.342867749705831 no 1153 0.33796720206597 1582 1838168 SGTC_2776 terbinafine 19.92 µM 0.416738862915323 0.343332206288219 no 1154 0.338434712515182 1580 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2896 9052656 71.43 µM 0.414928727374752 0.343990188434399 no 1155 0.339097039578336 1587 6469436 SGTC_180 1486-1293 102.781 µM 0.414594870903487 0.344111596561094 no 1156 0.339219251788567 1768 4140536 SGTC_2673 kobusone 100 µM 0.414590039991563 0.344113353457865 no 1157 0.339221020326659 1663 6710676 An epoxy ketone and protein crosslinker. SGTC_1915 st067105 30.6 µM 0.414306139031893 0.344216607921967 no 1158 0.339324959234127 1535 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_366 0181-0206 4.31 µM 0.413394552868946 0.344548229283252 no 1159 0.339658782430977 1775 274874 SGTC_718 1130-0073 349 µM 0.41291215102788 0.344723768204861 no 1160 0.339835489091843 1672 6740020 SGTC_462 ag-879 158 µM 0.412684458984301 0.344806633602032 no 1161 0.339918906271112 1684 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1292 0kpi-0043 232 µM 0.412584722886396 0.344842933532488 no 1162 0.339955448022859 1588 3333905 SGTC_204 PMA1.184 62.41 µM 0.411689463380712 0.345168835921389 no 1163 0.340283524444494 1611 2252213 YGL008C PMA1 SGTC_3262 9137218 49.47 µM 0.410267585770571 0.345686679736774 no 1164 0.340804833603305 1573 17650664 SGTC_584 0986-0246 15.4 µM 0.408935184625177 0.346172198686612 no 1165 0.341293613717353 1668 53315 YDR232W HEM1 SGTC_2312 7706453 155.7 µM 0.408239866500172 0.346425668918404 no 1166 0.341548791130646 1603 976098 SGTC_376 3970-0862 59.1 µM 0.40681508998186 0.346945269610697 no 1167 0.342071901422359 1711 3135186 SGTC_1702 st027038 51 µM 0.406057464073812 0.347221684972395 no 1168 0.342350189259098 1631 5521182 SGTC_722 3534-0461 190 µM 0.404946639020768 0.347627109906385 no 1169 0.342758367431508 1585 658262 SGTC_3177 9107506 49.47 µM 0.403820192682318 0.348038414280013 no 1170 0.343172473262743 1700 8897194 SGTC_293 4049-0273 38.5 µM 0.40347698479218 0.348163766875102 no 1171 0.343298681311815 1616 1380311 SGTC_2907 7721985 69.9 µM 0.403406757324074 0.348189418666732 no 1172 0.343324508256459 1573 3267881 SGTC_1061 3448-9325 110 µM 0.403045597669758 0.34832134941572 no 1173 0.343457340353633 1631 723482 SGTC_1201 1889-3372 45.9 µM 0.402806467777425 0.348408713088321 no 1174 0.34354530136448 1619 5392199 SGTC_1988 st071872 53.4 µM 0.401917330230285 0.348733620957028 no 1175 0.343872434043565 1696 16414116 SGTC_1760 st045453 10.4495 µM 0.399212754022609 0.349722606146982 no 1176 0.344868223198604 1695 3323419 YIL048W NEO1 SGTC_1916 st067606 49.2 µM 0.397884009994312 0.350208863688577 no 1177 0.345357843616689 1726 19590279 SGTC_3123 9126162 49.47 µM 0.397274575923081 0.350431969993761 no 1178 0.345582496749593 1641 25239884 SGTC_2421 5690543 90.72 µM 0.397030054510423 0.350521500783162 no 1179 0.345672648950787 1659 3397993 SGTC_1006 4099-6547 255 µM 0.396435082374345 0.350739382742474 no 1180 0.34589204480755 1661 3146833 SGTC_3338 9144300 39.5675 µM 0.394978958326564 0.35127283012016 no 1181 0.346429208455079 1685 4901274 SGTC_2369 9071472 200 µM 0.394873712521689 0.351311398027535 no 1182 0.346468045582225 1683 17296037 SGTC_1429 4049-0205 9.46 µM 0.393924121088487 0.351659450250201 no 1183 0.346818530615345 1647 22774478 SGTC_2953 9074162 66.49 µM 0.393596490301728 0.351779565111331 no 1184 0.346939486416371 1790 16451992 SGTC_2460 5552655 174.22 µM 0.393376092118684 0.351860375053091 no 1185 0.347020862512273 1580 5401989 SGTC_1235 benzylparaben 21.5 µM 0.391903908985979 0.352400328826334 no 1186 0.347564607306081 1641 7180 SGTC_2955 9076254 12.21 µM 0.391271771418056 0.352632269816147 no 1187 0.347798181080036 1758 16459619 SGTC_859 0439-0102 54.6 µM 0.390700336626767 0.352841985183242 no 1188 0.348009375004314 1751 610143 SGTC_2945 9067681 61.76 µM 0.389428525665682 0.353308897578174 no 1189 0.348479586882036 1661 16456930 SGTC_2290 7904846 200 µM 0.388027176281394 0.353823622407086 no 1190 0.348997961210757 1626 2962154 SGTC_2262 9014885 67.46 µM 0.387556625689634 0.353996518725454 no 1191 0.349172086250547 1755 6457424 SGTC_1460 k062-0059 9.15 µM 0.386992960607289 0.354203668114378 no 1192 0.349380709673419 1590 1373085 SGTC_3035 9091303 49.47 µM 0.385803216299575 0.354641045957877 no 1193 0.349821206557076 1661 25237002 SGTC_2064 5220758 200 µM 0.383720244207462 0.355407256588384 no 1194 0.350592903229529 1669 788518 SGTC_2809 7964133 12.99 µM 0.381163939571626 0.356348379220457 no 1195 0.351540802508227 1679 1253665 SGTC_18 0111-0177 500 nM 0.380872076851027 0.356455886456026 no 1196 0.351649086535723 1682 721752 SGTC_1273 0849-0096 14.1 µM 0.38012176892504 0.356732313698547 no 1197 0.351927513612655 1630 5286025 SGTC_1170 0310-0127 64.8 µM 0.379092352842633 0.357111691954211 no 1198 0.352309642395192 1712 774975 SGTC_1297 1068-0111 14.1 µM 0.376791943593099 0.357959988916146 no 1199 0.353164114164866 1601 767057 SGTC_2080 5212524 12.4 µM 0.376566081275322 0.358043315617663 no 1200 0.353248049235056 1784 260183 SGTC_1422 4031-0024 15.5 µM 0.376131700825765 0.35820358929068 no 1201 0.353409493984937 1714 782427 SGTC_1546 5-methoxyflavanone 78.7 µM 0.374753808924787 0.358712156312172 no 1202 0.353921784957768 1763 147795 SGTC_63 0099-0242 26.702 µM 0.373491335872599 0.359178343354038 no 1203 0.35439139627888 1720 3898502 YLR359W ADE13 SGTC_1478 0453-0656 35.7 µM 0.372732423669401 0.359458684018103 no 1204 0.354673801023099 1684 5258496 SGTC_3251 9135047 49.47 µM 0.371802762722031 0.359802202032247 no 1205 0.355019853282456 1769 17682963 SGTC_3033 9090887 49.47 µM 0.371741191057079 0.359824957314662 no 1206 0.35504277663254 1602 19325384 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.369938829298578 0.36049128308621 no 1207 0.355714034499343 1626 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_457 grayanotoxin iii 135 µM 0.366509911432683 0.361760108865335 no 1208 0.356992309061522 1677 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3142 9086498 49.47 µM 0.364756926328948 0.362409366444554 no 1209 0.357646430385337 1795 25236367 SGTC_535 2293-4129 48.2 µM 0.364625728039364 0.362457974639157 no 1210 0.357695403497877 1789 396118 YIL048W NEO1 SGTC_866 0495-0101 262 µM 0.363854498240819 0.362743755547096 no 1211 0.357983332058805 1615 635694 SGTC_402 epigallocatechin gallate 10 µM 0.363764497813039 0.362777110390435 no 1212 0.358016937809854 1646 65064 An antioxidant. SGTC_46 0329-0187a 2.197 µM 0.362864702655837 0.363110638525949 no 1213 0.358352977682816 1740 46494817 SGTC_218 alverine citrate 93.75 µM 0.360399523634047 0.364024940635816 no 1214 0.359274191404592 1748 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3214 9129694 49.47 µM 0.360111847806843 0.364131686341058 no 1215 0.359381746542886 1801 17158655 SGTC_2855 9016525 58.44 µM 0.359577434646828 0.364330014988745 no 1216 0.359581580462815 1653 43811474 SGTC_3302 9125395 16.351 µM 0.356565375052992 0.365448513018384 no 1217 0.36070860123577 1708 17599668 SGTC_3102 9121669 49.47 µM 0.355839875585225 0.365718091449953 no 1218 0.360980242314448 1739 41905072 SGTC_822 1487-0950 154 µM 0.35456185308082 0.366193135629654 no 1219 0.361458929259414 1807 1958375 SGTC_2740 felodipine 17.08 µM 0.354421887515076 0.366245173659523 no 1220 0.361511366951975 1815 3333 L-type calcium channel blocker SGTC_447 ml7 120 µM 0.354059707648322 0.366379840528959 no 1221 0.361647068659329 1771 4216 Selective myosin light chain kinase inhibitor. SGTC_2095 5432005 200 µM 0.353877485722703 0.366447601088011 no 1222 0.361715350229768 1670 783734 SGTC_2234 tolnaftate 200 µM 0.353494241512948 0.366590126841811 no 1223 0.361858972542509 1731 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2182 6325192 200 µM 0.353219040904753 0.366692483311118 no 1224 0.361962117084228 1721 736248 SGTC_618 k072-0232 33.2 µM 0.350575932517922 0.367676027050627 no 1225 0.362953257498687 1719 5872756 YGL099W LSG1 SGTC_1841 st054148 70 µM 0.350573346549902 0.367676989757788 no 1226 0.362954227662921 1658 675442 SGTC_1619 st003326 88.7 µM 0.350034606512761 0.367877570641766 no 1227 0.363156363143173 1797 2849032 SGTC_2995 9067767 71.4286 µM 0.348264082964181 0.368537016287677 no 1228 0.363820932529548 1710 11673567 SGTC_3155 9099265 49.47 µM 0.348037994580117 0.368621252644587 no 1229 0.363905824787145 1742 25236499 SGTC_1126 isoteolin 1.0172 µM 0.346089870711693 0.369347348807413 no 1230 0.364637587801532 1625 133323 SGTC_2870 9038528 12.99 µM 0.346059782289906 0.369358566894913 no 1231 0.364648893625785 1686 6463316 SGTC_528 3492-0019 172 µM 0.345751828402726 0.36947339000077 no 1232 0.364764615086752 1710 2869262 SGTC_485 niflumic acid 177 µM 0.344285018269139 0.370020461703852 no 1233 0.365315975044335 1758 4488 A COX2 inhibitor. SGTC_401 neomycin 50 µM 0.342726325300119 0.370602091013702 no 1234 0.365902178083583 1744 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2049 5262831 67.185 µM 0.342720284449632 0.370604345745205 no 1235 0.365904450574718 1705 763417 SGTC_2401 5128683 200 µM 0.342007587200375 0.370870389286381 no 1236 0.366172591217867 1610 708373 SGTC_405 ebelactone b 50 µM 0.341704980608055 0.370983368315176 no 1237 0.366286461758054 1700 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_873 0591-4978 488 µM 0.341396835562675 0.371098426570558 no 1238 0.366402428512518 1875 3305145 SGTC_2602 kawain 100 µM 0.339698252575145 0.371732866923133 no 1239 0.367041888909719 1733 5369129 SGTC_972 1319-0219 195 µM 0.338741528538468 0.372090367946985 no 1240 0.367402226503637 1684 23903702 SGTC_67 0335-0847 266 µM 0.337202751596145 0.372665597101385 no 1241 0.367982031586046 1923 4552207 YOR254C SEC63 SGTC_211 3455-0679 143.504 µM 0.337034701985351 0.37272843502594 no 1242 0.368045370265093 1733 748649 SGTC_1321 1326-2144 215 µM 0.336187793773045 0.373045166564269 no 1243 0.368364628469945 1824 3513030 SGTC_3301 9125354 19.7965 µM 0.335591175446681 0.373268344811666 no 1244 0.368589589721108 1688 41905162 SGTC_865 0488-0499 301 µM 0.33380348985702 0.373937322378204 no 1245 0.369263924904392 1806 9634651 SGTC_1944 st076371 56.9 µM 0.332804307445657 0.374311396395172 no 1246 0.369641003273449 1669 24208455 SGTC_709 3807-1509 243 µM 0.332277573825256 0.374508642648934 no 1247 0.369839836153772 1738 1886677 YPL242C IQG1 SGTC_598 3937-0236 20.2 µM 0.331142589660012 0.374933772421064 no 1248 0.370268391378261 1790 1379313 SGTC_3128 9127691 49.47 µM 0.326435754142255 0.376698423671663 no 1249 0.372047344933903 1757 41316314 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.326400706709538 0.376711573110561 no 1250 0.372060601452495 1764 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3052 9092717 49.47 µM 0.32562685542333 0.377001950632492 no 1251 0.372353345500287 1716 25237534 SGTC_2959 9079155 11 µM 0.323687069837444 0.377730135145727 no 1252 0.373087480531596 1768 16189457 SGTC_3097 9117246 49.47 µM 0.323656522330951 0.377741605990276 no 1253 0.373099045294713 1715 16423892 SGTC_3246 9135460 32.98 µM 0.323031447576766 0.377976350457622 no 1254 0.373335712991788 1811 41446951 SGTC_2236 dapsone 200 µM 0.322670414384906 0.378111955647331 no 1255 0.373472430251895 1808 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1120 ficusin 1.78878 µM 0.322140498576378 0.378311020866631 no 1256 0.373673129389573 1837 6199 A DNA cross-linker. SGTC_3226 9131256 49.47 µM 0.32176590252975 0.378451759021782 no 1257 0.373815023739524 1743 17178073 SGTC_440 fluspirilene 35.1 µM 0.321351745794332 0.378607379152003 no 1258 0.373971923308378 1823 3396 An atypical antipsychotic. SGTC_2 0422-0095 29 µM 0.321219605988131 0.378657035063153 no 1259 0.374021987685683 1730 6790840 SGTC_1336 1486-0901 104 µM 0.321035942502763 0.378726056031374 no 1260 0.374091576590503 1782 5006114 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.32026375236155 0.379016288351009 no 1261 0.374384199300128 1722 16486 A toxic proline analog. SGTC_2035 5154463 94.595 µM 0.320251201796649 0.379021006120338 no 1262 0.374388955955259 1842 2769623 SGTC_856 0433-0016 11.3 µM 0.31983720910961 0.379176636464479 no 1263 0.374545869600415 1747 3911780 SGTC_2583 asiatic acid 100 µM 0.319796754124374 0.379191845569631 no 1264 0.374561204172553 1767 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1990 st072050 59.8 µM 0.317096423296546 0.380207460244741 no 1265 0.375585219375547 1703 17233948 SGTC_2619 obliquin 87.91 µM 0.317049032165679 0.380225291804517 no 1266 0.375603198817798 1815 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2978 9011784 42.97 µM 0.316859719027817 0.380296525995602 no 1267 0.375675023909779 1920 2994934 SGTC_2762 leflunomide 42.06 µM 0.315596467096091 0.380771962545048 no 1268 0.376154409793993 1769 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_704 1310-0270 142 µM 0.315536611696745 0.380794494152613 no 1269 0.376177128803309 1703 5718033 SGTC_1882 5615643 20 µM 0.315268250847404 0.380895519269899 no 1270 0.376278994438709 1788 2253075 SGTC_1868 st057644 42.7 µM 0.314781929878662 0.381078616709465 no 1271 0.376463616327567 1730 688665 SGTC_2077 5212015 200 µM 0.312372440447281 0.381986169612009 no 1272 0.377378746273855 1730 780900 SGTC_2263 7948595 193.29 µM 0.311704431321625 0.38223789553896 no 1273 0.377632579964641 1743 2971371 SGTC_3259 9138485 49.47 µM 0.31108944528784 0.382469684784973 no 1274 0.377866312391056 1872 17646153 SGTC_1940 st075990 51.1 µM 0.30999641080102 0.382881755174057 no 1275 0.378281842886784 1837 1084979 SGTC_1317 1273-0028 910 nM 0.308319299017221 0.383514278440351 no 1276 0.378919691191253 1762 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2447 5741742 33.78 µM 0.308313057079519 0.383516633170355 no 1277 0.378922065776281 1820 1776504 SGTC_1846 st056244 14.8 µM 0.30726200938277 0.383913195300966 no 1278 0.379321975005507 1804 5393182 SGTC_3057 9095946 49.47 µM 0.305759102942369 0.384480455671744 no 1279 0.379894034593205 1797 24540043 SGTC_3192 9110362 49.47 µM 0.305017939717005 0.384760293164762 no 1280 0.380176244529734 1799 16649480 SGTC_1091 telmisartan 47.6 µM 0.304644653315895 0.384901255892057 no 1281 0.380318403559413 1850 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2678 equilin 100 µM 0.300313968713311 0.38653774352279 no 1282 0.381968839610518 1890 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2378 9074213 121.43 µM 0.299644012940509 0.38679108887448 no 1283 0.382224354185197 1755 657714 SGTC_249 wiskostatin 11.211 µM 0.298832587192862 0.3870979960294 no 1284 0.382533892705556 1874 2775510 A n-wasp and actin depolymerizer. SGTC_955 1216-0110 33 µM 0.298704757891745 0.38714635159871 no 1285 0.382582663218887 1715 3619719 SGTC_1352 1496-0991 99 µM 0.297978212164132 0.387421224274033 no 1286 0.382859896424438 1752 3000039 SGTC_1615 st002656 86.5 µM 0.294898960099991 0.388586816929795 no 1287 0.384035533179418 1768 1584458 SGTC_1671 st016596 74.5 µM 0.2946070214459 0.388697377050786 no 1288 0.384147048891023 1779 2829167 SGTC_1825 st052143 62.6 µM 0.294327806718519 0.38880312692757 no 1289 0.384253713247925 1875 674173 SGTC_754 3474-0146 171 µM 0.293505872440056 0.389114474386907 no 1290 0.384567755747413 1679 24762078 SGTC_2487 5918373 44.05 µM 0.292708690707383 0.389416513652613 no 1291 0.384872413242004 1911 2876279 SGTC_2116 5511452 16.8835 µM 0.292620279326306 0.389450015414378 no 1292 0.384906205641921 1816 870744 SGTC_1384 3089-0840 101 µM 0.291882063310725 0.389729779968461 no 1293 0.385188399015619 1897 1069836 SGTC_1638 st008370 60.6 µM 0.290758895387725 0.39015554079205 no 1294 0.385617862226527 1777 24207134 SGTC_525 k781-2675 26.7 µM 0.290502034267543 0.39025292802851 no 1295 0.385716097365415 1816 3651118 YDL195W SEC31 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.290172086813419 0.390378035582039 no 1296 0.38584229473039 1803 4620898 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.290090790377294 0.390408862834721 no 1297 0.385873390616164 1894 23847180 SGTC_1247 0448-0043 5.84 µM 0.288317673228082 0.391081392171897 no 1298 0.386551790003113 1790 3089013 YGL099W LSG1 SGTC_1290 0986-0249 10.2 µM 0.287870547556753 0.391251034929843 no 1299 0.386722916332133 1895 53329 SGTC_1358 1509-0022 2.48 µM 0.28679732655578 0.391658307220184 no 1300 0.387133755046079 1839 3258434 SGTC_1856 st057054 55.7 µM 0.286150385456656 0.391903869685084 no 1301 0.387381471080877 1928 1266018 SGTC_2908 7930301 100 µM 0.285962419268004 0.391975224970827 no 1302 0.387453452601772 1765 2223178 SGTC_1924 st058459 75.1 µM 0.285841186351596 0.392021249055143 no 1303 0.38749988071527 1830 688683 SGTC_1196 1588-0294 184 µM 0.285692602087523 0.392077658689625 no 1304 0.387556785665674 1757 6144269 SGTC_2019 4016004 108 µM 0.285061244264767 0.392317377350144 no 1305 0.387798610643344 1751 45595336 SGTC_1042 0350-0096 82 µM 0.284446704494995 0.392550749658264 no 1306 0.388034035712512 1751 3122515 SGTC_167 3672-0051 66.205 µM 0.283771735271424 0.392807114658095 no 1307 0.388292658225584 1762 3237971 SGTC_529 4076-0302 30.3 µM 0.283486195596203 0.392915581577013 no 1308 0.388402081077868 1784 5816522 SGTC_500 h-89 112 µM 0.282670443070064 0.39322550431027 no 1309 0.388714737784912 1928 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_301 4119-0100 24.5 µM 0.280739941884626 0.39395921440571 no 1310 0.389454935509473 1827 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_908 3448-7491 47.7 µM 0.27975835759376 0.394332421842272 no 1311 0.389831451126741 1761 1203031 SGTC_2582 agaric acid 100 µM 0.278712855032074 0.394730038304288 no 1312 0.390232598202269 1750 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1266 0828-0227 32.9 µM 0.278490884217602 0.39481447044742 no 1313 0.390317780860473 1869 3913820 SGTC_2642 cholecalciferol 100 µM 0.278206585311191 0.394922617852478 no 1314 0.390426889996215 1884 9821465 A vitamin D precursor, similar to steriods. SGTC_1452 4194-0072 190 µM 0.275679053065363 0.395884447059082 no 1315 0.391397292819747 1960 1343545 SGTC_702 1488-0190 94 µM 0.27412098297376 0.396477672742965 no 1316 0.391995824572181 1954 949357 SGTC_1699 st031318 29.054 µM 0.273430367845844 0.396740697003827 no 1317 0.39226120585059 1896 5340658 SGTC_2412 st077135 33.4 µM 0.272054886015503 0.397264696087904 no 1318 0.392789908669149 1886 13258915 SGTC_1306 1185-0270 9.02 µM 0.27133228966451 0.397540048420918 no 1319 0.393067737029076 1914 1548076 SGTC_752 1896-0090 130 µM 0.270985368181551 0.397672264360183 no 1320 0.393201142932672 1803 772567 SGTC_21 0849-0113 22.993 µM 0.269964915154996 0.398061239340361 no 1321 0.393593622695731 1796 1560156 SGTC_351 caspofungin 25 nM 0.269658330857706 0.398178122564662 no 1322 0.393711560223279 1868 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3304 9125678 46.087 µM 0.269408286159743 0.398273457208302 no 1323 0.393807755191982 1795 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1534 6-azauridine 81.6 µM 0.268163015124195 0.398748332522022 no 1324 0.394286921161123 1833 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2373 9071805 200 µM 0.268086186230782 0.398777635595522 no 1325 0.39431648928401 1997 10149009 SGTC_1406 3909-7906 11.9 µM 0.265450878043716 0.399783104828521 no 1326 0.395331073214083 1882 X1406 SGTC_2710 st078562 53.7235 µM 0.263453866220587 0.400545483196171 no 1327 0.396100388621056 1840 17250908 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.263245414134758 0.400625083671033 no 1328 0.396180714685713 1857 368090 SGTC_2224 6650123 117.647 µM 0.260925038451503 0.401511430968345 no 1329 0.397075157802675 1851 2908370 SGTC_1512 0259-0544 12.2 µM 0.259110278426168 0.402204994526238 no 1330 0.397775077260386 1873 18476 SGTC_2846 9008642 19.48 µM 0.259033000408892 0.402234535430696 no 1331 0.397804889288576 1803 2992898 SGTC_965 1291-5240 308 µM 0.257952938492405 0.402647466786042 no 1332 0.398221613967921 1934 2834598 SGTC_3167 9103034 49.47 µM 0.255012565696392 0.403772184952301 no 1333 0.399356696999538 1861 5127859 SGTC_1824 st053723 68.6 µM 0.254862983016972 0.403829422986845 no 1334 0.399414463793467 1792 675225 SGTC_1933 st074711 15.9 µM 0.254318474688793 0.404037797292099 no 1335 0.399624764085842 1973 17250958 SGTC_1710 st031758 61.5 µM 0.254189422784907 0.404087187309237 no 1336 0.399674610851363 1958 5394341 SGTC_1649 st011737 51.3 µM 0.251678537083826 0.40504844267425 no 1337 0.400644774008559 1851 1761035 SGTC_1305 1181-0477 144 µM 0.251567107050609 0.405091115335475 no 1338 0.400687842916064 1975 6252086 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.251413149766022 0.40515007586644 no 1339 0.400747351050395 1860 5379071 SGTC_3277 9138724 49.47 µM 0.248428141959084 0.406293658764537 no 1340 0.401901580890365 1897 15943418 SGTC_1038 k292-0204 154 µM 0.248372100066368 0.406315136588825 no 1341 0.40192325914466 1808 4454212 SGTC_1761 st044296 37 µM 0.245018154422842 0.407601033469301 no 1342 0.403221187266313 1850 1826700 SGTC_592 k241-0073 46.5 µM 0.244093280884877 0.407955804181119 no 1343 0.403579288132635 1986 4230158 SGTC_2453 5731132 22.18 µM 0.243239816436193 0.408283250169712 no 1344 0.403909811920664 1984 1362040 SGTC_1844 rapamycin 4 nM 0.242914715711616 0.40840799738915 no 1345 0.404035732733535 1884 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_771 0250-0039 27.3 µM 0.242598582319202 0.408529312577604 no 1346 0.40415818977909 1874 3005115 SGTC_3206 9114350 49.47 µM 0.242585575249109 0.408534304187404 no 1347 0.404163228383149 1979 17087243 SGTC_2150 5556613 200 µM 0.242400681557077 0.408605260830634 no 1348 0.404234853157818 1906 743190 SGTC_477 mead ethanolamide 10 µM 0.241849021835942 0.40881698905203 no 1349 0.404448576127444 1949 16061185 SGTC_192 3455-0609 60.9 µM 0.240907725369572 0.409178322131043 no 1350 0.404813317238434 1900 3769639 SGTC_1157 4092-0394 27.6 µM 0.240225752444412 0.409440157577314 no 1351 0.405077625275092 1959 3659885 SGTC_2014 4013930 200 µM 0.239803205744512 0.409602409668757 no 1352 0.405241410826321 2031 64556 SGTC_893 0958-0369 48.9 µM 0.239536508531409 0.409704825683906 no 1353 0.405344795282674 2023 6819948 SGTC_746 1095-0025 46.6 µM 0.239131462651467 0.409860381592762 no 1354 0.40550182285762 1942 6749286 SGTC_3072 9116419 49.47 µM 0.239083695246626 0.409878727369036 no 1355 0.405520342256102 1843 17170162 SGTC_578 3460-0051 92 µM 0.238066714678259 0.410269360505248 no 1356 0.405914675224946 2009 2876744 SGTC_3008 9078912 71.4286 µM 0.237908356136055 0.410330195741038 no 1357 0.405976087156971 1840 16648731 SGTC_1220 1838-0075 193 µM 0.236805969166145 0.410753749955944 no 1358 0.406403660265613 1923 5529645 SGTC_3024 9090631 49.47 µM 0.234534424957696 0.411626840259055 no 1359 0.407285055539274 2037 25236383 SGTC_1864 st057645 30.4 µM 0.233318439312939 0.412094396443025 no 1360 0.407757070592682 2024 688666 SGTC_369 0957-0393 4.5 µM 0.232761099730263 0.412308739712632 no 1361 0.407973460607858 1817 6997992 SGTC_189 3970-0742 2.116 µM 0.232752802881028 0.412311930736679 no 1362 0.407976682115301 2008 2891807 SGTC_2731 amoxapine 43.43 µM 0.23268554916878 0.412337797180895 no 1363 0.408002795671572 2010 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1465 k213-0056 144 µM 0.232668527534973 0.412344343930328 no 1364 0.408009404968456 1873 24048857 YMR208W ERG12 SGTC_137 0438-0332 85.389 µM 0.232566750894181 0.412383489104892 no 1365 0.408048924167255 1960 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2085 5307070 144.047 µM 0.23237024514951 0.412459071306906 no 1366 0.408125228698964 1833 2840351 SGTC_2975 9084847 53.72 µM 0.231970382787668 0.412612880790255 no 1367 0.408280508759024 1842 27211724 SGTC_854 0422-0053 192 µM 0.231800315491839 0.412678302276201 no 1368 0.408346556001075 1962 3596728 SGTC_2707 st078556 66.6 µM 0.23112803683302 0.412936938155398 no 1369 0.408607667245922 2036 17250899 SGTC_1777 st045864 34.765 µM 0.230455975755569 0.413195528106295 no 1370 0.408868734538315 1918 4691462 SGTC_630 4356-0227 183 µM 0.229982098655083 0.413377885158409 no 1371 0.409052840056528 1926 779312 SGTC_962 1254-0300 21.5 µM 0.229141394522126 0.413701450292643 no 1372 0.409379510529658 1893 7340576 SGTC_123 0083-0120 66.675 µM 0.228881229078851 0.413801593082926 no 1373 0.409480615180018 1812 16001701 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.228161642987003 0.414078605083862 no 1374 0.409760289727652 1873 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_785 1270-0111 65.3 µM 0.227525580901895 0.414323499269489 no 1375 0.41000754004938 1941 6741994 SGTC_1787 fluconazole 80 µM 0.227455983185838 0.414350297538935 no 1376 0.410034596276598 1925 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1147 3809-1045 12.3 µM 0.227208872024292 0.414445449736272 no 1377 0.410130664608624 1879 325925 SGTC_1662 st014054 52 µM 0.225384021117396 0.415148278770515 no 1378 0.410840270591368 2013 2838777 SGTC_3 0833-0587 95.581 µM 0.224515552305424 0.415482859218335 no 1379 0.411178083395625 1944 5382644 SGTC_337 1315-0038 354 µM 0.221977110396877 0.416461152774921 no 1380 0.412165851047002 1910 1626437 SGTC_2489 cantharidin 73.42 µM 0.221807465643514 0.416526550917375 no 1381 0.412231883737925 1842 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_398 bronopol 33.3 µM 0.221677419893595 0.416576685187621 no 1382 0.412282504556282 1930 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1013 4112-3890 241 µM 0.221576821967848 0.416615467882646 no 1383 0.412321663694654 1882 705171 SGTC_1067 clotrimazole 1.36 µM 0.220587464922861 0.4169969297944 no 1384 0.412706831097961 1894 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1131 3454-3128 32.3 µM 0.220460557520558 0.417045866569417 no 1385 0.4127562436139 1961 710982 SGTC_950 1165-0508 94.1 µM 0.219581407216086 0.417384911050775 no 1386 0.413098586456175 1864 6148369 SGTC_3196 9111891 49.47 µM 0.219486296406907 0.417421594239419 no 1387 0.413135626757122 2001 18891510 SGTC_531 3788-1495 174 µM 0.219267705436164 0.417505905086199 no 1388 0.413220758553443 1869 2896655 SGTC_174 3553-0389 74.3 µM 0.2188267142396 0.417676007554629 no 1389 0.413392518103132 1957 738071 SGTC_392 N-ethylmaleimide 8.33 µM 0.215808599377123 0.418840589589131 no 1390 0.414568472466374 1891 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_470 aa-861 153 µM 0.215079424804482 0.419122058958516 no 1391 0.414852697573943 1889 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3317 9138495 8.753 µM 0.214527197105418 0.419335252453582 no 1392 0.415067980195334 2017 17020139 SGTC_202 3594-0513 34.79 µM 0.213120150961536 0.41987856479317 no 1393 0.415616623745094 2025 708429 SGTC_887 0885-0007 9.62 µM 0.212599483323503 0.420079652518806 no 1394 0.41581968723991 2000 5719458 SGTC_951 1171-0579 82.7 µM 0.209288448189103 0.421358897802525 no 1395 0.417111534555918 1946 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2238 6671620 73.2395 µM 0.208663027016208 0.421600628013265 no 1396 0.41735565245979 2002 729941 SGTC_530 4358-1714 28 µM 0.206708665136597 0.422356194304696 no 1397 0.418118694878233 1989 1564641 SGTC_1774 st048371 48.465 µM 0.206477784559158 0.422445472846054 no 1398 0.418208858106985 1865 4242727 SGTC_729 4092-0585 94.1 µM 0.20334900241128 0.423655723566491 no 1399 0.419431128571101 1878 2169061 SGTC_2670 beta-carotene 100 µM 0.202478446268899 0.423992593816479 no 1400 0.419771353412843 2022 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2008 4012253 172 µM 0.20192886208913 0.4242052894308 no 1401 0.419986169069909 1923 603940 SGTC_594 1487-1584 10.8 µM 0.201711507406712 0.424289414373815 no 1402 0.420071132953888 1876 5013332 SGTC_2338 7999974 200 µM 0.201687603255753 0.424298666445553 no 1403 0.420080477307187 2074 315925 SGTC_1205 4161-2785 76 µM 0.201191613839723 0.424490647934261 no 1404 0.420274374306533 1845 3498106 SGTC_711 k292-0785 179 µM 0.200455515561989 0.424775600821956 no 1405 0.42056217264822 1979 4146315 SGTC_781 4335-2806 94.4 µM 0.198401245962592 0.425571041880858 no 1406 0.421365571342029 2062 845254 SGTC_120 rhodamine 6G 52.259 µM 0.19641856015808 0.426339052138154 no 1407 0.422141285148385 2080 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1707 st032323 6.317 µM 0.19572804484318 0.426606594887948 no 1408 0.422411516170269 1994 3132057 YMR211W DML1 SGTC_551 k048-0028 34.9 µM 0.195669428571994 0.426629307539046 no 1409 0.422434457149381 2033 6836383 SGTC_1272 0839-0021 27 µM 0.195162269527024 0.426825831835927 no 1410 0.422632957810763 1978 5027250 SGTC_290 2043-6722 48.1 µM 0.195029288081697 0.426877365197814 no 1411 0.42268500963771 2012 773758 YLR208W SEC13 SGTC_520 3584-0023 682 µM 0.19411898623798 0.427230161522051 no 1412 0.423041357760857 1900 1340790 SGTC_2897 9048598 12.99 µM 0.194116791059026 0.427231012355448 no 1413 0.423042217165127 1953 6467404 SGTC_1007 4101-0031 70 µM 0.194003073258707 0.427275088907053 no 1414 0.423086737755238 2066 1146276 SGTC_589 1227-0070 34.1 µM 0.193402668628289 0.42750781830937 no 1415 0.423321812814247 1990 2841384 SGTC_1767 st044992 70.3 µM 0.192514047131143 0.427852312879103 no 1416 0.423669782843608 1930 9600693 SGTC_1163 k060-0048 49.9 µM 0.19247013822713 0.42786933660428 no 1417 0.423686978416975 1980 6809982 SGTC_867 0518-0118 155 µM 0.189916031955479 0.428859807788236 no 1418 0.424687464708835 2118 6848158 SGTC_1803 st050068 52.4 µM 0.188153630644702 0.429543520976448 no 1419 0.425378110298611 2044 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1957 st077035 62.4 µM 0.187927885544783 0.429631112771198 no 1420 0.425466591338248 2096 705593 SGTC_1573 oleylamine 1.06 µM 0.186567454976991 0.430159049272657 no 1421 0.425999892912742 1942 5356789 An amine of the fatty acid oleic acid. SGTC_3180 9109287 49.47 µM 0.186256454018297 0.430279755662866 no 1422 0.426121827258373 1979 18891271 SGTC_3257 9139206 32.98 µM 0.185781186138894 0.430464230281919 no 1423 0.42630817948206 2057 4910041 SGTC_2695 st077686 51.995 µM 0.185369129861351 0.430624181683216 no 1424 0.426469759797186 1927 2876092 SGTC_264 promethazine 12.5 mM 0.185326430934348 0.430640757141356 no 1425 0.426486504104825 2116 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_165 k038-0023 64.381 µM 0.185166559627105 0.430702819274454 no 1426 0.426549198527781 1976 46368543 SGTC_2382 9035899 200 µM 0.182761254738848 0.431636765746338 no 1427 0.427492675371442 1946 6462679 SGTC_1949 st076024 69.1 µM 0.182677803233406 0.431669175698131 no 1428 0.427525416562264 1940 2921930 SGTC_946 3434-1334 87.4 µM 0.182677545783909 0.431669275684167 no 1429 0.427525517570239 2032 4047976 SGTC_562 3772-2733 112 µM 0.182151542655841 0.43187356941664 no 1430 0.427731900037033 2070 2876874 YIL048W NEO1 SGTC_114 0364-0001 490.298 µM 0.180850851505191 0.432378821435352 no 1431 0.428242323710364 1931 4003655 SGTC_3070 9117005 49.47 µM 0.180787784350774 0.432403322618742 no 1432 0.428267075895057 2093 8779016 SGTC_2949 9072542 2.23 µM 0.180616107837906 0.43247001915513 no 1433 0.428334455800579 1956 16457352 SGTC_1055 3448-0672 86 µM 0.18038291282007 0.432560618788141 no 1434 0.428425983945331 2005 748378 SGTC_2647 atorvastatin 60.16 µM 0.180318238189021 0.432585746444815 no 1435 0.428451369170663 2052 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3289 9119912 71.43 µM 0.180051766877679 0.43268927986179 no 1436 0.428555964064508 2007 17014829 SGTC_610 4215-0184 155 µM 0.178322013436447 0.4333614615774 no 1437 0.429235045824822 2014 5605015 SGTC_3173 9105693 49.47 µM 0.177409692279511 0.433716067120446 no 1438 0.429593297368721 2042 17096658 SGTC_2868 9035608 32.47 µM 0.176989520469654 0.433879399560885 no 1439 0.429758310541896 2046 6462614 SGTC_90 0870-0863 4.608 µM 0.174540679474538 0.434831555782815 no 1440 0.430720281891257 1950 1738164 SGTC_650 1328-0195 38 µM 0.1744895460578 0.434851441482064 no 1441 0.430740372890899 2106 2780821 SGTC_3149 9097855 49.47 µM 0.17433021978442 0.434913404256723 no 1442 0.43080297545239 2088 25236625 YMR079W SEC14 SGTC_3205 9113483 49.47 µM 0.174316612733032 0.434918696180326 no 1443 0.430808322022653 2073 17018033 SGTC_2456 5770359 74.46 µM 0.17388132228861 0.435087991301675 no 1444 0.430979365834018 2078 3118787 SGTC_1963 st076565 50.3 µM 0.17246688549635 0.435638182434937 no 1445 0.431535246396214 1999 4914280 SGTC_1903 st060211 78.3 µM 0.172220867405529 0.435733891913035 no 1446 0.431631946582764 2101 688960 SGTC_3309 9129340 25.759 µM 0.171957214857642 0.435836465978334 no 1447 0.431735582739769 2039 17158987 SGTC_1849 st056239 19.2 µM 0.171638789836631 0.4359603550368 no 1448 0.431860755043796 1882 5393181 SGTC_2854 9024559 71.43 µM 0.17029246745347 0.436484235610909 no 1449 0.432390067421651 1957 3163529 SGTC_993 3909-8757 62.7 µM 0.168888168927262 0.437030794566186 no 1450 0.432942302673551 2001 4288324 YLR208W SEC13 SGTC_1355 1499-0035 1.68 µM 0.168691436807701 0.43710737316687 no 1451 0.433019677343907 1990 1548538 SGTC_148 3253-0744 288.01 µM 0.168340872822971 0.437243837147276 no 1452 0.433157560393225 2145 6893655 SGTC_2062 5245942 200 µM 0.167993691140521 0.437378991858316 no 1453 0.433294121142878 2117 1376160 SGTC_1341 1486-1360 280 µM 0.166973627602758 0.437776135651854 no 1454 0.433695399856712 1962 3976547 SGTC_1961 st076550 68.7 µM 0.166536981825223 0.437946155187776 no 1455 0.433867191107569 2024 1579337 SGTC_1328 1441-0025 69.2 µM 0.165581219543687 0.438318346348594 no 1456 0.434243263944537 2079 4562601 SGTC_3198 9112019 49.47 µM 0.158903023206054 0.440920461624601 no 1457 0.436872639393804 2051 45595555 SGTC_766 1391-0721 126 µM 0.157686543156971 0.441394733232948 no 1458 0.437351902413954 2109 1020919 YIL115C NUP159 SGTC_11 0438-0307 1.3 µM 0.157008964813232 0.441658938601016 no 1459 0.437618891417647 2144 4011476 SGTC_1284 0929-0043 16 µM 0.156993711657321 0.441664886501286 no 1460 0.437624902009269 2023 1239883 SGTC_92 0063-0024 660.874 µM 0.156985637972583 0.441668034804045 no 1461 0.43762808349584 2161 3594437 SGTC_1822 st052468 42 µM 0.155798299398868 0.442131072998955 no 1462 0.438096005570212 2057 2873678 SGTC_2016 5121758 140 µM 0.155767197606239 0.442143203138954 no 1463 0.438108263741919 2129 2795203 SGTC_2113 5491891 107.031 µM 0.155502161884767 0.442246573026991 no 1464 0.438212724867906 1994 789979 SGTC_1402 3909-7673 35.9 µM 0.155382917808217 0.442293082179939 no 1465 0.438259725108966 2108 5328014 SGTC_1491 4138-0063 26.5 µM 0.154176125224451 0.442763816045845 no 1466 0.438735433203491 2150 23883227 SGTC_1574 spiramycin 23.7 µM 0.153176375725007 0.443153849800169 no 1467 0.439129593621286 2106 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1719 st032227 49.2 µM 0.151967808811513 0.443625423317206 no 1468 0.439606162780867 2012 3125804 SGTC_1287 0971-0001 34.6 µM 0.151538188061402 0.443793077301414 no 1469 0.439775594467361 2052 4665869 SGTC_3065 9113888 49.47 µM 0.150892094625747 0.444045225904519 no 1470 0.440030418329779 2084 16648368 SGTC_2943 9068529 45.32 µM 0.150871223065525 0.444053371752842 no 1471 0.440038650636905 2131 3270634 SGTC_820 1582-0060 59.9 µM 0.150709105143067 0.444116644684244 no 1472 0.440102595206997 2014 3848840 SGTC_2333 9017922 200 µM 0.15029184812313 0.444279502286804 no 1473 0.440267182099009 2122 3163164 SGTC_194 1486-1323 56.904 µM 0.149823959992178 0.444462132666365 no 1474 0.440451752690776 1994 5178754 SGTC_459 nigericin 15.3 µM 0.149727652816634 0.444499725629632 no 1475 0.440489745157606 2064 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1417 3966-0327 90.4 µM 0.149223972082365 0.444696342691859 no 1476 0.440688452390666 2049 651118 SGTC_55 0767-0285 6.563 µM 0.147805016792523 0.44525031979917 no 1477 0.441248325000645 2148 3116166 SGTC_2425 5628681 7.85 µM 0.14705187596383 0.445544398490883 no 1478 0.441545537124049 2084 5714958 SGTC_1607 st000305 50.6 µM 0.145397572015601 0.446190459072163 no 1479 0.44219849077264 2146 5457690 SGTC_2979 9012552 45.46 µM 0.14518402545834 0.446273866536531 no 1480 0.442282789067059 2190 17100905 SGTC_2353 9059630 146.67 µM 0.144416900215466 0.446573511513042 no 1481 0.442585636129324 2117 4779114 SGTC_313 3474-0040 5.03 µM 0.143938794669652 0.446760278632301 no 1482 0.442774400467083 2073 1043375 YIL048W NEO1 SGTC_2778 tioconazole 65.09 nM 0.143711078025399 0.446849238001739 no 1483 0.442864311506108 2112 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2058 5236698 133 µM 0.143203896245738 0.447047382317661 no 1484 0.44306457639007 2057 766665 SGTC_488 nitrendipine 139 µM 0.141577643697806 0.447682810879007 no 1485 0.443706813387038 2155 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1345 1488-0192 31.4 µM 0.14113814493377 0.447854560133814 no 1486 0.443880404973623 2141 658348 SGTC_87 0100-0052 35.5 µM 0.140832649082948 0.447973948903985 no 1487 0.444001074934012 2122 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3306 9127676 59.7925 µM 0.140609483296724 0.448061165797195 no 1488 0.444089228043815 2018 41905287 SGTC_2787 5284540 71.43 µM 0.140012773848287 0.448294382074333 no 1489 0.444324948867603 2047 736958 SGTC_441 propafenone 146 µM 0.139897847532754 0.448339301613868 no 1490 0.44437035099261 2113 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2665 lovastatin 100 µM 0.139585572532015 0.448461359241994 no 1491 0.444493720231689 2062 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1150 3909-7983 10.9 µM 0.139241751834673 0.448595752647674 no 1492 0.444629558322828 2026 23965914 SGTC_679 0422-0091 41.4 µM 0.137747853239171 0.449179759385687 no 1493 0.445219849218744 2063 627384 YHR062C RPP1 SGTC_1082 camptothecin 424.86 nM 0.137663132625352 0.449212882354165 no 1494 0.445253328909591 2045 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1519 esterone 74 µM 0.137649907029085 0.44921805315847 no 1495 0.445258555404538 1947 698 A steroid. SGTC_456 gingerol 170 µM 0.136443354775547 0.449689814419997 no 1496 0.445735400986962 2107 442793 A herb. SGTC_2159 5658611 73.75 µM 0.133812699248633 0.450718644935516 no 1497 0.446775342481979 2173 793844 SGTC_2361 9034121 116 µM 0.132777614010641 0.451123550535244 no 1498 0.447184629506521 2057 6496917 SGTC_331 k048-0133 24.5 µM 0.132403814047377 0.451269786472956 no 1499 0.447332449032277 2099 6813582 SGTC_2834 9001755 58.44 µM 0.131571183825221 0.451595547171151 no 1500 0.447661739657808 2024 2989575 SGTC_60 0986-0278 202 µM 0.13066651644034 0.451949528843993 no 1501 0.448019560600956 1892 3110598 SGTC_1229 0139-0193 12.2 µM 0.12972952701027 0.45231619788083 no 1502 0.448390210396678 2193 3090752 SGTC_2061 5245884 80.95 µM 0.129291521006603 0.452487615319836 no 1503 0.448563490189618 2117 573863 SGTC_2717 st081029 62.2815 µM 0.128737927620987 0.452704281546943 no 1504 0.44878251160474 2186 5292846 SGTC_257 daunorubicin 18.5 µM 0.12873482676846 0.452705495203077 no 1505 0.448783738457332 2165 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2680 butyl paraben 22.24 µM 0.12763102601941 0.45313754455849 no 1506 0.4492204883552 2184 7184 An antifungal and steroid mimetic. SGTC_2752 diclazuril 33.15 µM 0.125646176852243 0.453914592860556 no 1507 0.45000600436685 2178 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3325 9138760 55.175 µM 0.124507550792834 0.454360433238415 no 1508 0.450456711116802 2055 43844959 SGTC_3135 9127742 49.47 µM 0.12205025710234 0.455322806314512 no 1509 0.451429608169398 2035 3643468 SGTC_1357 1503-1303 39.5 µM 0.121471499540308 0.455549508955616 no 1510 0.451658793795323 2152 292895 SGTC_286 k060-0067 22.9 µM 0.121170915220015 0.455667255265429 no 1511 0.451777830318086 2122 5985051 SGTC_2608 thymoquinone 42.66 µM 0.121157286642137 0.455672594008691 no 1512 0.451783227570435 2206 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2962 9082311 13.18 µM 0.120977813164331 0.45574290016985 no 1513 0.451854304316995 2094 16459453 SGTC_686 1319-0111 510 µM 0.120677990054476 0.455860354663913 no 1514 0.451973046479305 2182 4562600 SGTC_232 clozapine 119 µM 0.118471158791149 0.456724989939295 no 1515 0.452847173043501 2184 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2874 9043904 71.43 µM 0.118376156565931 0.456762216388909 no 1516 0.452884808616733 2058 4463428 SGTC_2381 9035592 200 µM 0.117585326244791 0.457072116511529 no 1517 0.453198116119855 2020 4749657 SGTC_1798 st045719 60.953 µM 0.11681057373983 0.457375741590173 no 1518 0.453505082242651 2197 3980186 SGTC_1246 0422-0085 105 µM 0.116239823321666 0.457599434289797 no 1519 0.453731238103315 2200 264295 SGTC_919 tnp00227 403.569 nM 0.116052085698594 0.457673016738477 no 1520 0.453805631106191 2106 1269246 A methoxyflavone. YNL221C POP1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.114709498995483 0.458199276347736 no 1521 0.454337692261695 2129 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_934 2950-0684 338 µM 0.11445199236313 0.45830022075802 no 1522 0.454439750393123 2224 1121253 SGTC_1979 st071809 45.3 µM 0.113943369158529 0.458499612526268 no 1523 0.454641342902053 2170 4976333 SGTC_1403 3909-7815 62.9 µM 0.112855525657087 0.45892610670412 no 1524 0.455072548187594 2124 6615483 SGTC_2325 6158266 200 µM 0.112573635987617 0.459036630612311 no 1525 0.455184293795127 2107 3623240 SGTC_1466 k213-0079 57.5 µM 0.112231606336699 0.459170738584774 no 1526 0.45531988462125 2120 3657981 SGTC_1048 3161-0300 24.5 µM 0.110563284107019 0.459824945014494 no 1527 0.455981331981724 2192 2165101 SGTC_2820 7989630 71.43 µM 0.108930575916545 0.460465291298745 no 1528 0.456628777432667 2219 2984098 SGTC_2836 9010338 19.48 µM 0.108603152621969 0.460593718737244 no 1529 0.456758630058456 2044 2994051 SGTC_423 5-fluorouracil 457 µM 0.108478281730537 0.460642698769394 no 1530 0.456808153754227 2034 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_8 0354-0001 70 µM 0.108236610911741 0.460737494730724 no 1531 0.456904002112721 2148 4993152 SGTC_373 0844-0104 25.9 µM 0.108093982025648 0.460793442302541 no 1532 0.456960570916033 2238 5375804 SGTC_484 loperamide 105 µM 0.106558301015871 0.461395877094396 no 1533 0.457569700566347 2222 3955 An opioid-receptor agonist. SGTC_2091 4-phenylthiadiazole 200 µM 0.10629410231543 0.461499529001159 no 1534 0.457674505376469 2143 270010 SGTC_1254 0550-0035 264 µM 0.105837109686389 0.461678825066831 no 1535 0.457855796428773 2171 15121435 SGTC_3256 9138902 49.47 µM 0.105766368269934 0.461706580385831 no 1536 0.457883860654784 2220 17228773 SGTC_2135 5326629 150.42 µM 0.105734913808914 0.461718921569838 no 1537 0.457896339198736 2118 5020077 SGTC_2127 5253358 187.912 µM 0.102704921831536 0.462907912482032 no 1538 0.459098583624387 2151 20612 SGTC_1217 1183-1422 255 µM 0.102291410298178 0.463070203359602 no 1539 0.459262686566848 2189 2849664 SGTC_2272 7805186 180 µM 0.100706334146226 0.463692354925231 no 1540 0.459891791509475 2236 2956062 YPR165W RHO1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.100029447699757 0.463958063920787 no 1541 0.460160473400748 2194 17037758 SGTC_2786 7743617 45.45 µM 0.100020685858736 0.46396150345116 no 1542 0.460163951427143 2103 583674 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0999491276040289 0.463989594313925 no 1543 0.460192356701505 2054 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2635 hydroquinidine 100 µM 0.0995835055726636 0.464133125463945 no 1544 0.4603374946851 2164 442912 An experimental heart treatment. SGTC_821 1114-0266 29.2 µM 0.0994287539811534 0.464193877241587 no 1545 0.460398926749896 2149 3123235 SGTC_2354 9060492 162 µM 0.0976187345826187 0.464904509227211 no 1546 0.461117523756549 2207 6471895 SGTC_3172 9105863 49.47 µM 0.0970804702421128 0.465115858968585 no 1547 0.46133124504185 2233 2348785 SGTC_1339 1486-1321 22.7 µM 0.0964184955067807 0.465375797141208 no 1548 0.461594101634547 2112 3469382 SGTC_805 3852-0218 479 µM 0.0953961688792715 0.46577726398052 no 1549 0.462000079496764 2149 6615355 SGTC_1146 3579-1023 7 µM 0.0932364811793473 0.466625485608767 no 1550 0.462857846407227 2231 X1146 SGTC_3347 9188721 44.724 µM 0.0930340908115577 0.466704982656093 no 1551 0.46293823905454 2153 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2783 7738165 71.43 µM 0.0929235664103377 0.466748396170186 no 1552 0.462982141729757 2124 17201110 SGTC_350 k064-0020 19.8 µM 0.0928806237574226 0.466765263968106 no 1553 0.462999199599053 2245 2790705 SGTC_2013 4024628 200 µM 0.0922795697158879 0.467001363180748 no 1554 0.463237960052999 2180 5230760 SGTC_1227 3909-8010 46.6 µM 0.0908754549328798 0.46755295668163 no 1555 0.463795776801355 2151 15982272 SGTC_2848 9016370 25.97 µM 0.0900885599636941 0.467862108402117 no 1556 0.464108420039644 2242 7894410 SGTC_56 0957-0365 83.25 µM 0.0893779390558752 0.468141310578045 no 1557 0.464390777687957 2248 6752360 SGTC_228 caffeine 993.056 µM 0.0892033642914986 0.468209903214838 no 1558 0.464460145860563 2248 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3038 9091290 49.47 µM 0.0879318003302913 0.468709545150614 no 1559 0.46496544074022 2234 25236843 SGTC_2556 citropten 84.59 µM 0.0872831467783213 0.468964442842464 no 1560 0.465223224906663 2241 2775 A potential DNA crosslinker. SGTC_2340 7987427 183.45 µM 0.087044968310722 0.469058041677097 no 1561 0.465317884093541 2203 2239331 SGTC_1572 epiandrosterone 68.9 µM 0.0869824574458896 0.469082607338667 no 1562 0.465342728090504 2172 441302 A steroid. SGTC_1769 st044406 64.4 µM 0.0867470556219854 0.469175117137237 no 1563 0.465436286193382 2099 670903 SGTC_3212 9128307 49.47 µM 0.0856188308185641 0.469618517554145 no 1564 0.465884714299579 1979 27243542 SGTC_671 0560-0003 407 µM 0.0815082438237913 0.471234322283065 no 1565 0.467518884535745 2213 3238678 SGTC_3148 9097893 49.47 µM 0.0810969341384383 0.471396027920949 no 1566 0.467682431930975 2180 17174100 SGTC_280 3448-3607 3.04 µM 0.0809245523613088 0.471463800899962 no 1567 0.467750977018915 2260 626179 SGTC_949 1165-0505 146 µM 0.0804572118741273 0.471647542900992 no 1568 0.467936812920571 2178 6244267 SGTC_2652 actinonin 100 µM 0.0801812958593499 0.471756026302972 no 1569 0.468046533000823 2282 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3238 9133470 49.47 µM 0.0796705278825075 0.47195685325383 no 1570 0.468249650131354 2272 3534688 SGTC_1248 0469-0687 58.6 µM 0.0789944643261385 0.472222683111793 no 1571 0.468518513066594 2202 4017482 SGTC_2197 6588183 93.1375 µM 0.0774070472117578 0.472846907865213 no 1572 0.469149867370803 2259 884136 SGTC_999 SEC7.066 22.7 µM 0.076770504462781 0.473097236282679 no 1573 0.469403057748975 2207 740511 YDR170C SEC7 SGTC_3182 9108849 49.47 µM 0.0754962342869448 0.473598390832963 no 1574 0.469909946795836 2192 17133045 SGTC_1188 1403-0014 4.57 µM 0.0750187115529063 0.473786205368867 no 1575 0.470099912088079 2200 9614867 SGTC_927 2425-1185 123 µM 0.0747202218666416 0.473903607352848 no 1576 0.470218658962861 2278 730375 SGTC_2793 7325131 81.82 µM 0.0746415591570848 0.473934547352971 no 1577 0.470249953453424 2212 4176441 SGTC_2816 7982706 58.44 µM 0.0746187266578252 0.473943527972256 no 1578 0.470259036971444 2201 2981853 SGTC_1322 1348-1070 12 µM 0.0745526910746177 0.473969501569218 no 1579 0.47028530818213 2256 6758089 SGTC_796 1234-0020 70.7 µM 0.073315984744806 0.47445595223878 no 1580 0.470777335972456 2288 46495034 SGTC_1404 3909-7820 48.3 µM 0.0728272465325288 0.47464820488587 no 1581 0.470971794462074 2268 23741373 SGTC_682 0kpi-0099 17 µM 0.0719986108533588 0.474974174863745 no 1582 0.471301506681126 2187 1714895 YML126C ERG13 SGTC_2330 7979373 200 µM 0.0715900576041764 0.47513489834893 no 1583 0.471464076327891 2213 1863007 SGTC_1510 1123-0200 71.5 µM 0.071011121637624 0.475362656749968 no 1584 0.471694452025503 2267 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_574 1315-0397 40 µM 0.0709585179101127 0.475383351910052 no 1585 0.471715385070838 2281 6794277 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0706468978680535 0.475505949651869 no 1586 0.471839392265179 2258 279621 SGTC_970 1315-0089 19.5 µM 0.0698690420113803 0.475811984258384 no 1587 0.472148946894035 2279 6811083 YLR033W RSC58 SGTC_2684 capsaicin 100 µM 0.0691286300185968 0.476103300450183 no 1588 0.47244361603717 2227 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_699 0375-0592 111 µM 0.0682165545797546 0.476462175420729 no 1589 0.472806624509778 2308 762578 SGTC_3271 9137798 49.47 µM 0.0678137497109944 0.47662067343357 no 1590 0.472966949136644 2274 6498326 SGTC_2161 5662504 8.5105 µM 0.0663122644637106 0.477211519010678 no 1591 0.473564609543945 2202 2859334 SGTC_674 0498-0004 451 µM 0.06626276482975 0.477230998343784 no 1592 0.473584313702827 2201 4231473 SGTC_3004 9076122 71.4286 µM 0.0661620132559016 0.477270646753824 no 1593 0.473624419754929 2280 44782551 SGTC_1153 4055-0057 267 µM 0.0654640184350197 0.477545332341042 no 1594 0.473902276993884 2205 882706 SGTC_2261 9010538 184.68 µM 0.0649420317042429 0.477750759514636 no 1595 0.474110077373572 2141 6457250 SGTC_2974 9094440 9.66 µM 0.0647223588039437 0.477837213258783 no 1596 0.474197530196476 2230 25236134 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0637183195709613 0.478232372853123 no 1597 0.474597258739843 2243 4330530 SGTC_2990 9074105 71.4286 µM 0.0636651476734536 0.478253300310205 no 1598 0.474618428275749 2310 6502001 SGTC_3125 9127534 49.47 µM 0.0636491992286939 0.47825957732928 no 1599 0.474624777906528 2309 1639235 SGTC_1581 himbacine 57.9 µM 0.0628086285174798 0.478590418335293 no 1600 0.474959447437072 2177 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3079 9117512 49.47 µM 0.0624175668404612 0.478744341705745 no 1601 0.475115152959987 2299 7185044 SGTC_1617 st002906 78 µM 0.0621826125155594 0.478836822151887 no 1602 0.475208704446913 2301 5150859 SGTC_2558 carylophyllene oxide 100 µM 0.0620796685117743 0.478877342333053 no 1603 0.475249693970627 2310 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0620418782382567 0.478892217161258 no 1604 0.475264741103287 2241 6708739 YPR165W RHO1 SGTC_1175 0741-0056 27.6 µM 0.0603866238208891 0.47954377910958 no 1605 0.475923855930067 2287 765927 SGTC_3286 9117135 37.221 µM 0.0599723794336422 0.479706847786969 no 1606 0.476088816550354 2234 3438150 SGTC_1748 st037455 53.6035 µM 0.0589230861745966 0.480119920695369 no 1607 0.476506684943709 2264 580690 SGTC_595 3909-8003 73.7 µM 0.0584735999640556 0.480296875474591 no 1608 0.476685695340499 2253 699517 SGTC_2186 6124449 200 µM 0.0584531440702223 0.480304928691202 no 1609 0.47669384212681 2267 3834182 YLR033W RSC58 SGTC_324 1315-0088 19.6 µM 0.0580448103345947 0.480465685994855 no 1610 0.476856467593689 2296 6787421 SGTC_1476 4112-3294 3.34 µM 0.0579797282017787 0.48049130853694 no 1611 0.476882387954951 2267 704369 SGTC_2240 6690706 185.951 µM 0.057495295643636 0.480682029975354 no 1612 0.477075326722054 2282 805876 SGTC_188 3229-0966 278.469 µM 0.0567073520502867 0.480992253347984 no 1613 0.477389158676482 2306 5722370 SGTC_2759 disulfiram 3.38 µM 0.0566701481070882 0.481006901297711 no 1614 0.477403977072975 2278 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3113 9123498 49.47 µM 0.0549967279590634 0.481665787091089 no 1615 0.478070535279909 2314 8897275 SGTC_1518 st038567 90.8 µM 0.0547028830625529 0.481781489632412 no 1616 0.478187586226136 2302 77966 SGTC_653 0203-0016 55.2 µM 0.0512472942659714 0.483142253330071 no 1617 0.479564232977707 2271 295302 SGTC_1583 clindamycin 39.6 µM 0.0511874375663893 0.483165825857386 no 1618 0.479588081046062 2162 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3151 9099821 49.47 µM 0.0472401798572141 0.484720445141802 no 1619 0.481160902178721 2271 17174189 SGTC_1923 st058458 19.1 µM 0.0464375096525601 0.485036604329433 no 1620 0.481480770183893 2341 3534982 SGTC_375 3970-0961 9.27 µM 0.0458200495846143 0.485279818564743 no 1621 0.481726839167529 2281 2898222 SGTC_326 k292-0812 17.5 µM 0.0447398779698737 0.485705305531309 no 1622 0.482157323741649 2330 3579357 SGTC_1955 wogonin 32.4 µM 0.0443416103954591 0.485862189977597 no 1623 0.482316051988103 2299 5281703 A flavanone. SGTC_663 1486-0733 13.9 µM 0.0441443485219926 0.485939895633563 no 1624 0.482394671105795 2287 722445 YPR165W RHO1 SGTC_2288 7946289 167.31 µM 0.0439149490506599 0.48603026164546 no 1625 0.482486099588761 2310 1246052 SGTC_2465 5809242 33.21 µM 0.0435326688474218 0.486180852674638 no 1626 0.482638461613551 2333 2731748 SGTC_3319 9138450 16.7555 µM 0.0429005964405768 0.486429848259796 no 1627 0.482890386649506 2214 2029690 SGTC_399 oxolinic acid 75 µM 0.041391889105072 0.487024202425466 no 1628 0.48349173940697 2243 4628 A DNA gyrase inhibitor. SGTC_178 4092-0806 87.505 µM 0.04081797835794 0.487250301788917 no 1629 0.483720503322846 2335 2169044 SGTC_3236 9132701 49.47 µM 0.040377864970853 0.487423692778271 no 1630 0.483895938524741 2290 24282524 SGTC_2699 st077704 54.6 µM 0.0401622830288352 0.487508626229451 no 1631 0.483981873568357 2306 645852 SGTC_1704 st028805 70.8 µM 0.0396442882801146 0.487712704451428 no 1632 0.484188359116286 2256 2876101 SGTC_2479 5617353 43.85 µM 0.0383872431750871 0.48820796508025 no 1633 0.48468946597896 2339 2731746 SGTC_1758 st042942 75.2445 µM 0.0353282051242189 0.489413263669814 no 1634 0.48590901646354 2334 669317 SGTC_2612 dictamnine 15.46 µM 0.0351285534947301 0.489491932345996 no 1635 0.485988616531051 2293 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1413 3910-0535 34.4 µM 0.0348848474275347 0.489587960333799 no 1636 0.48608578163035 2327 2876951 SGTC_2941 9056145 11.23 µM 0.0340658093050183 0.489910691949592 no 1637 0.486412336436811 2360 2119517 SGTC_3267 9137951 49.47 µM 0.0339288486826341 0.489964660201419 no 1638 0.486466944252308 2318 16643986 SGTC_763 3453-1109 128 µM 0.0338510130375223 0.489995330804735 no 1639 0.48649797835518 2343 1560353 SGTC_283 0987-0079 11.7 µM 0.0326129826759131 0.490483176029254 no 1640 0.486991608330069 2327 411556 SGTC_2175 5807670 165.306 µM 0.030875698561183 0.491167775778219 no 1641 0.487684335209955 2342 241186 SGTC_2789 5281112 71.43 µM 0.0302408440735667 0.491417955170899 no 1642 0.487937487277415 2334 765948 SGTC_3279 9140807 49.47 µM 0.0301050120110784 0.491471483442396 no 1643 0.487991651768694 2339 45595718 SGTC_17 0960-0276 49.807 µM 0.0294457930985098 0.491731268519667 no 1644 0.488254525505779 2349 6821114 SGTC_138 0850-0259 40.9225 µM 0.0290792727136443 0.491875708446162 no 1645 0.488400683392521 2361 6813004 SGTC_1600 coumarin 106 71.1 µM 0.0255168379116333 0.493279660672888 no 1646 0.489821359074365 2329 100336 A hepatotoxic, DNA x-linker. SGTC_1214 0358-0031 63.7 µM 0.0226821734977861 0.49439685959213 no 1647 0.490951897833084 2354 4301366 SGTC_2493 resveratrol 26.09 µM 0.0225573929241464 0.494446039229012 no 1648 0.491001665346133 2363 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2515 chrysin 20.77 µM 0.0224594448263693 0.494484643469443 no 1649 0.491040731086435 2355 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1054 3429-0080 167 µM 0.0221439748345074 0.494608979866986 no 1650 0.49116655410991 2361 1162877 SGTC_2069 5228469 200 µM 0.0219875504141515 0.494670631722713 no 1651 0.491228943234399 2343 2835210 SGTC_3068 9116768 49.47 µM 0.021423938041633 0.494892770389173 no 1652 0.49145373907526 2337 41904888 SGTC_395 anisomycin 6.25 µM 0.0207706954812415 0.495150237315946 no 1653 0.491714287156319 2313 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1034 k072-0165 12.7 µM 0.0204841831990985 0.4952631629912 no 1654 0.491828564704494 2370 5835461 SGTC_2797 7859098 81.82 µM 0.0203027077980407 0.495334689728113 no 1655 0.491900947861354 2352 972681 SGTC_793 0488-0545 106 µM 0.020177260377769 0.495384133677592 no 1656 0.491950983891381 2351 292548 SGTC_870 0573-2213 57.6 µM 0.0194065619693565 0.495687898910053 no 1657 0.492258387850331 2373 3916321 SGTC_2007 4011539 71.82 µM 0.0193609775455823 0.495705865762746 no 1658 0.492276569988188 2365 45595301 SGTC_2713 st079149 53.4 µM 0.0190130048810624 0.495843017580182 no 1659 0.492415365445314 2352 3103253 SGTC_1487 3970-0795 2.82 µM 0.018889946631849 0.495891520538793 no 1660 0.49246444976853 2324 3765103 SGTC_1077 5-fluorocytosine 377 nM 0.0188213474388963 0.495918558686076 no 1661 0.492491812022438 2353 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2511 berberine 10.47 µM 0.0187380580589096 0.495951386947667 no 1662 0.492525033818811 2380 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1494 4358-1428 177 µM 0.0180415318299116 0.49622592174276 no 1663 0.492802860593017 2374 1564571 SGTC_1234 0326-0494 15.5 µM 0.0179783447224106 0.496250826939202 no 1664 0.492828064513895 2356 1547813 SGTC_3037 9091026 49.47 µM 0.017633344872166 0.496386808874523 no 1665 0.492965677723474 2373 25236398 YIL048W NEO1 SGTC_511 blebbistatin 171 µM 0.0174302804348127 0.496466847063611 no 1666 0.493046676264048 2374 3476986 A myosin inhibitor. SGTC_314 1671-0008 2.74 µM 0.0171985275347176 0.496558193032071 no 1667 0.493139118436702 2364 3913060 SGTC_3012 9080433 71.4286 µM 0.0169157686152177 0.496669643390887 no 1668 0.493251906515645 2373 17688859 SGTC_72 0744-0168 198.391 µM 0.016280087413849 0.49692020016456 no 1669 0.493505471689564 2316 677577 SGTC_1693 xanthone 101.9 µM 0.0155282013823144 0.497216561186135 no 1670 0.49380539287682 2338 7020 An insecticide. SGTC_2625 euphol 100 µM 0.0153449445770476 0.497288793348319 no 1671 0.493878493054552 2385 6708538 A triterpene alcohol. SGTC_1523 st012844 44.7 µM 0.0151667078167075 0.497359046904197 no 1672 0.493949590959926 2287 4274103 SGTC_2125 5246583 200 µM 0.0136070375126691 0.497973807656199 no 1673 0.494571744933939 2373 835267 SGTC_2040 5100729 123 µM 0.0134618551040276 0.498031033124484 no 1674 0.494629659030435 2376 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2205 7238770 200 µM 0.011321368587638 0.498874736822114 no 1675 0.495483523880595 2387 279867 SGTC_2105 5350118 200 µM 0.01071682006733 0.499113029434077 no 1676 0.495724689200584 2377 2133313 SGTC_9 0092-0002 10.449 µM 0.0100119039272335 0.499390883966171 no 1677 0.496005894943218 2393 759368 SGTC_2237 6667747 47.222 µM 0.00909046232528121 0.499754086069237 no 1678 0.496373480177272 2337 729940 YDL015C TSC13 SGTC_1005 4092-0690 4.4 µM 0.00784269861021288 0.499754086069237 no 1679 0.496871248005812 2383 1529343 SGTC_2027 5150920 200 µM 0.0057024729582461 0.498910480033058 no 1680 0.497725054763636 2387 786715 SGTC_2124 5246320 200 µM 0.00561366666207077 0.498875475612908 no 1681 0.497760482782838 2392 579342 SGTC_2028 5153890 36.43 µM 0.00403478497007892 0.498253135871216 no 1682 0.498390358050467 2394 2830968 YPR165W RHO1 SGTC_285 1486-1325 46 µM 0.00251333573975657 0.497653437994487 no 1683 0.498997325164193 2399 22310230 SGTC_3335 9143315 29.6265 µM 0.00230965692056789 0.497573155862263 no 1684 0.499078581020384 2395 4899691 SGTC_158 k038-0087 26.446 µM 0.00205710573552898 0.497473610313841 no 1685 0.499179334125641 2395 X158 SGTC_1785 bathophenanthroline 24 µM 0.00168139396386921 0.497325520094541 no 1686 0.499329221173859 2400 72812 An iron chelator. SGTC_3087 9117406 49.47 µM 0.00115397830557712 0.497117635032016 no 1687 0.499539629365416 2396 42546093 SGTC_371 0195-0006 7.36 µM 0.000802375616555774 0.496979048476324 no 1688 0.49967989847614 2376 3928593 SGTC_1724 st037281 8.293 µM 0.000448385459314982 0.496839521252366 no 1689 0.499821120088356 2402 574124 YDL195W SEC31 SGTC_244 nsc-207895 1.295 µM 0.000289025266278507 0.496776708655524 no 1690 0.499884695602783 2391 42640 SGTC_605 1315-0399 119 µM 0.000220303185226711 0.49674962153688 no 1691 0.499912111745617 2404 24020461 SGTC_1178 0988-0033 191 µM 0.00012403041310536 0.49671167521414 no 1692 0.499950519024284 2403 5392207 SGTC_2666 tannic acid 100 µM 7.34605675787772e-05 0.496691742906265 no 1693 0.499970693473677 2405 16134267 A thiamine antagonist. SGTC_1130 3454-2858 15.9 µM 2.28462904450551e-05 0.496671793093763 no 1694 0.499990885648792 2404 715628 YIL048W NEO1 SGTC_2200 6600604 21.907 µM -0.0001523478532102 0.49660273971107 no 1695 0.499939222000261 2407 2904777 SGTC_2754 granisetron 64.02 µM -0.000727642690899663 0.496375985971511 no 1696 0.499709712591191 2408 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1984 st072354 53.1 µM -0.00131365327891408 0.496145009799365 no 1697 0.499475928315984 2407 5762938 SGTC_2985 9022375 71.43 µM -0.00151527333462026 0.496065541515271 no 1698 0.499395493631785 2423 4939335 SGTC_3001 9076041 71.4286 µM -0.00221442961329176 0.495789971202128 no 1699 0.499116571122296 2411 16004211 SGTC_1877 wortmannin 25 µM -0.0028852761641162 0.495525560968671 no 1700 0.498848942944557 2407 312145 A covalent inhibitor of PI 3-kinase. SGTC_1206 3978-0017 132 µM -0.00320750980414808 0.495398555161071 no 1701 0.498720390918452 2417 3873677 SGTC_45 0kpi-0036 14.9 µM -0.00456982119313989 0.494861616348496 no 1702 0.498176911457525 2393 2795021 SGTC_1011 4112-3381 17.4 µM -0.00539248855569591 0.494537376249081 no 1703 0.497848718744718 2462 2877139 SGTC_2893 9048488 25.97 µM -0.00564853478494784 0.494436460786703 no 1704 0.497746572634927 2416 6467338 SGTC_1295 1013-0063 9.78 µM -0.00586284246261762 0.494351996006918 no 1705 0.497661077657602 2416 6826038 SGTC_1826 st055655 41.6 µM -0.00613576984344282 0.494244427894088 no 1706 0.49755219734566 2430 676168 SGTC_1401 3807-4679 7.6 µM -0.00679427699497163 0.493984894032108 no 1707 0.497289496495764 2419 3291456 SGTC_2591 skatole 100 µM -0.00710251004781149 0.493863412674238 no 1708 0.497166532267658 2424 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2202 7226349 200 µM -0.00718016983675289 0.493832805349695 no 1709 0.497135551284376 2417 844334 SGTC_84 0443-0269 128.823 µM -0.00743475387291488 0.493732468785844 no 1710 0.497033989660391 2413 6150058 SGTC_2188 6126565 140.678 µM -0.00755447874486168 0.493685283001382 no 1711 0.496986227688381 2418 874518 SGTC_1098 clofazimine 15.1 µM -0.00775568453430139 0.493605984280978 no 1712 0.49690596054392 2436 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1455 4262-0120 131 µM -0.00863061692418927 0.493261161103802 no 1713 0.496556924747418 2421 1529587 SGTC_2323 6148992 148.28 µM -0.00955563124838831 0.492896605412316 no 1714 0.496187912692853 2445 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2417 cerulenin 830 nM -0.00988057635809884 0.492768543286148 no 1715 0.496058284471639 2418 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2299 7976368 114.88 µM -0.0099373912729426 0.492746152384355 no 1716 0.496035619712684 2435 2979718 SGTC_3278 9139605 49.47 µM -0.00994386851894786 0.492743599686754 no 1717 0.496033035793061 2449 7958859 SGTC_1828 st055811 49 µM -0.0111580778100249 0.49226508236644 no 1718 0.495548663361002 2421 5877589 SGTC_1605 st000082 49.1 µM -0.0116186387691244 0.49208357913848 no 1719 0.495364938037826 2477 1114022 SGTC_3140 9094243 49.47 µM -0.0118988635033058 0.491973145710436 no 1720 0.49525315227219 2428 19291112 SGTC_1665 st014639 11.4 µM -0.0125876041381305 0.491701723374862 no 1721 0.494978405110786 2432 981133 YIL048W NEO1 SGTC_107 0358-0022 2.6945 µM -0.0132829343954736 0.491427708065971 no 1722 0.494701031684073 2469 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0141164343485378 0.491099248272864 no 1723 0.494368544523991 2440 1273210 SGTC_1708 st033234 31.827 µM -0.0150929123090087 0.490714452406633 no 1724 0.493979027738648 2467 674664 SGTC_975 1335-0046 28.5 µM -0.0153426345536155 0.490616046963499 no 1725 0.493879414512091 2443 16486740 SGTC_1853 st056710 91.2 µM -0.0153465506314437 0.490614503800043 no 1726 0.493877852406987 2441 269167 SGTC_846 0335-0850 148 µM -0.0160337715887942 0.490343700789108 no 1727 0.493603724661135 2430 6819598 SGTC_2226 7298446 200 µM -0.0163884399145884 0.490203943614631 no 1728 0.493462251062046 2441 3283010 SGTC_1935 st074532 41.6 µM -0.0181094634147999 0.489525791108955 no 1729 0.492775764238507 2534 2829742 SGTC_215 1287-0124 461.5 µM -0.0186652840515232 0.489306781788238 no 1730 0.492554061370592 2493 5560863 SGTC_1733 st037357 54.9 µM -0.0187640605541092 0.489267861340123 no 1731 0.492514662147592 2450 1272339 YGL099W LSG1 SGTC_2875 9039966 71.43 µM -0.0190469824835245 0.489156383488647 no 1732 0.49240181279731 2502 6463691 SGTC_728 3030-5151 22.5 µM -0.0192117267174766 0.489091470800439 no 1733 0.492336101381071 2443 3125388 SGTC_1405 3909-7894 12 µM -0.0209774347057131 0.488395763263051 no 1734 0.491631828105564 2462 7104060 SGTC_1285 0929-0069 65.5 µM -0.0216220413345539 0.48814179015086 no 1735 0.491374725599141 2461 1206237 SGTC_1959 st077091 55.8 µM -0.0236367604750823 0.487348028218665 no 1736 0.490571174858125 2442 821356 YKL052C ASK1 SGTC_2478 5763493 32.33 µM -0.0245453474170761 0.486990078042973 no 1737 0.490208806294793 2459 1365576 YLR208W SEC13 SGTC_2843 9000894 45.46 µM -0.0245730691473895 0.486979156853815 no 1738 0.490197750259238 2447 2242070 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0265380174925322 0.486205075681771 no 1739 0.489414105347049 2450 77254 SGTC_673 1082-0474 110 µM -0.0265415678771567 0.486203677072392 no 1740 0.489412689447251 2456 3098046 SGTC_3292 9120825 59.784 µM -0.0266693030799958 0.486153358228003 no 1741 0.48936174850662 2446 24824900 SGTC_1879 gemcitabine 100 µM -0.0271484770447053 0.485964598764429 no 1742 0.489170654951093 2458 60750 A nucleoside analog which inhibits DNA replication. SGTC_3280 9140961 49.47 µM -0.0277362911111924 0.485733047353183 no 1743 0.48893623935432 2456 4901226 SGTC_3329 9141233 27.5565 µM -0.0281542314980126 0.485568415414809 no 1744 0.488769570356296 2485 4909101 YNL103W MET4 SGTC_1728 st035614 33.7865 µM -0.0282139457022656 0.485544893444109 no 1745 0.488745757295228 2561 15945546 SGTC_3152 9099253 49.47 µM -0.0294232611456214 0.485068543976798 no 1746 0.488263510561316 2488 25236131 SGTC_2869 9037858 32.47 µM -0.0295633063128042 0.485013381535889 no 1747 0.488207664917061 2451 27187042 SGTC_106 0092-0003 11.579 µM -0.029859727425124 0.484896625065359 no 1748 0.488089462187664 2509 1072148 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0302555118527076 0.484740732681069 no 1749 0.48793163835651 2448 97141 SGTC_234 nsc-17383 10.7 µM -0.0306028086926572 0.484603940607903 no 1750 0.487793151093762 2470 408974 SGTC_1265 0819-1001 68.8 µM -0.0306419261804264 0.484588533260911 no 1751 0.487777552789198 2460 3106768 SGTC_2098 5376439 882.5 nM -0.0308343195916258 0.484512754904549 no 1752 0.487700835174316 2511 2844116 SGTC_1622 st003707 19.4 µM -0.0309876792538003 0.484452351245162 no 1753 0.487639682743271 2542 10140899 SGTC_3085 9117376 49.47 µM -0.0313103918574546 0.484325245832001 no 1754 0.487511001484253 2516 16480349 SGTC_1072 oxiconazole 14.9 nM -0.0326148200671175 0.48381149271602 no 1755 0.486990875706769 2464 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3341 9147222 25.867 µM -0.0344043389307868 0.483106729030743 no 1756 0.486277361777618 2520 1939759 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0348358133050846 0.482936809901497 no 1757 0.486105331532428 2454 2346 DNA damaging agent; causes G2/M arrest. SGTC_2810 7959871 45.46 µM -0.0348712593230978 0.482922851025566 no 1758 0.486091199203537 2499 2974535 SGTC_1888 azatryptophan 97.5 µM -0.0369765831479381 0.482093798744133 no 1759 0.485251838454888 2553 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2187 6125751 200 µM -0.0371132110071081 0.48203999890317 no 1760 0.485197369212787 2497 874498 SGTC_32 0928-0142 34.1 µM -0.0372044818826613 0.482004059426911 no 1761 0.485160982531245 2484 2244242 SGTC_3138 9097216 49.47 µM -0.0373099585993123 0.481962526338691 no 1762 0.485118932604286 2460 25237486 SGTC_2495 cafestol 54.53 µM -0.0385185064488225 0.481486656018563 no 1763 0.484637138210081 2629 16667697 An anti-infammatory. SGTC_1366 1683-0113 21.9 µM -0.0393310260754892 0.481166738106972 no 1764 0.484313235257963 2475 708623 SGTC_2748 diazoxide 86.69 µM -0.0393347756166181 0.48116526180706 no 1765 0.484311740564125 2517 3019 A potassium channel activatior. SGTC_619 1652-1634 108 µM -0.0396369117515495 0.481046303154837 no 1766 0.48419129961419 2490 5400454 SGTC_582 0987-0078 156 µM -0.0398140250712154 0.480976569936966 no 1767 0.484120697353796 2477 1625765 SGTC_1642 st009582 77.7 µM -0.0404969926114038 0.48070767680286 no 1768 0.48384845231245 2484 6739311 SGTC_3320 9137005 35.139 µM -0.0407621893604048 0.480603267779732 no 1769 0.483742741404839 2502 4908713 SGTC_1149 3909-7961 23.3 µM -0.0415468880530065 0.480294336580075 no 1770 0.483429956920115 2489 735261 SGTC_1309 pyrazolanthrone 13.4 µM -0.0420572751062812 0.480093406579288 no 1771 0.483226519769537 2485 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3181 9108277 49.47 µM -0.0429099806911918 0.479757723374853 no 1772 0.48288664631947 2476 17097298 SGTC_2693 st077581 40.7 µM -0.0429416497396927 0.479745256547658 no 1773 0.482874023831661 2477 25238761 SGTC_599 1935-0052 86.5 µM -0.0432304163123744 0.479631581709357 no 1774 0.482758929517549 2485 9557311 SGTC_2104 5389443 200 µM -0.0447992210359088 0.479014040718207 no 1775 0.482133672997185 2547 2244536 SGTC_78 0336-0123 156.75 µM -0.0448147003663212 0.479007947715686 no 1776 0.482127503833723 2499 6765896 SGTC_2812 7970281 58.44 µM -0.0454534630435922 0.478756521069873 no 1777 0.481872933821454 2527 2233435 SGTC_2092 5303694 80.6725 µM -0.0461458464705233 0.478483998037272 no 1778 0.481597002353601 2499 1963699 SGTC_590 k048-0076 22.4 µM -0.0461971370606056 0.478463810391811 no 1779 0.481576562167511 2511 6832814 SGTC_1118 chelidonine 707.474 nM -0.0464669420813133 0.478357617786754 no 1780 0.481469041005144 2496 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1784 st039334 36.3 µM -0.0468568791643245 0.478204145099291 no 1781 0.481313647880496 2573 3496984 SGTC_816 0325-0417 81.3 µM -0.047103090547031 0.478107242097009 no 1782 0.481215532086648 2525 68101 SGTC_1349 flufenamic acid 69 µM -0.047493498231058 0.477953589481668 no 1783 0.481059956075023 2494 3371 A non-steroidal anti-inflammatory. SGTC_253 dyclonine 31.25 µM -0.0483589000534459 0.477613005305597 no 1784 0.480715106982279 2489 3180 An oral anasthetic. SGTC_1073 triclabendazole 3.09 µM -0.0498808607540423 0.477014068184549 no 1785 0.480108664610387 2526 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1818 st052136 56.3 µM -0.0504225672160608 0.476800902925177 no 1786 0.479892826609774 2517 674169 SGTC_1211 1056-0033 32.3 µM -0.0505668404856975 0.476744131507323 no 1787 0.479835343232485 2517 6741922 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0513045526558035 0.476453849751986 no 1788 0.479541420194736 2499 6312947 SGTC_646 4092-0839 27.3 µM -0.051310476428562 0.476451518861877 no 1789 0.47953906005985 2520 877796 SGTC_902 1120-0002 2.07 µM -0.0522394545157532 0.476085993958355 no 1790 0.479168947839306 2519 3280475 SGTC_2779 methotrexate 400 µM -0.0524676363097824 0.475996214360055 no 1791 0.47907804114245 2486 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_947 3447-0010 211 µM -0.0526818341030721 0.475911937965797 no 1792 0.478992706604752 2481 748350 SGTC_2576 guaiol 23.12 µM -0.0533913146279635 0.475632799667089 no 1793 0.478710062633383 2578 227829 SGTC_1872 amphotericin b 148 nM -0.0537764644900943 0.475481271152176 no 1794 0.478556630497944 2526 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2588 indole-3-carbinol 100 µM -0.0543069522730505 0.475272568524957 no 1795 0.478345305308247 2550 3712 Induces cell cycle arrest. SGTC_259 usnic acid 108.925 µM -0.0543449235537247 0.47525763025753 no 1796 0.47833017929618 2594 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2110 5483698 200 µM -0.0555951370472759 0.474765803780706 no 1797 0.477832169294607 2538 2848765 YHR062C RPP1 SGTC_2544 sphondin 68.51 µM -0.0574779646501315 0.474025183512043 no 1798 0.477082229373057 2578 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2766 oltipraz 83.91 µM -0.0575936354386981 0.473979686691761 no 1799 0.477036159721814 2539 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2307 7538926 6.34 µM -0.0576949682590984 0.47393982970696 no 1800 0.476995800884609 2547 96582 SGTC_1142 3253-1408 9.78 µM -0.0600076007293218 0.473030279458198 no 1801 0.47607479054744 2490 256655 SGTC_300 r073-0011 5.04 µM -0.0600793491940294 0.473002063262569 no 1802 0.476046218601828 2516 2735780 SGTC_3189 9110682 49.47 µM -0.0602529467607449 0.472933793889906 no 1803 0.475977088430495 2555 17122418 SGTC_2439 5492030 7.2 µM -0.0606380606925947 0.472782345953076 no 1804 0.475823730615885 2542 5722370 SGTC_2413 inermin 26.06 µM -0.060690610063754 0.472761680960491 no 1805 0.475802804990213 2671 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2087 5276107 200 µM -0.0618987253734725 0.472286611039219 no 1806 0.475321741279005 2513 144405 SGTC_2112 5488546 200 µM -0.0630418634756155 0.47183712854081 no 1807 0.474866584183373 2517 600757 SGTC_877 0771-0151 33.1 µM -0.0639748093888345 0.471470320275612 no 1808 0.474495142452122 2618 6166523 SGTC_1812 st052057 4.327 µM -0.0641469891120946 0.471402626655378 no 1809 0.474426593480768 2514 3645418 SGTC_1696 st025591 34.7925 µM -0.0646639785158 0.471199373754767 no 1810 0.474220771875224 2523 2787147 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0662512455756956 0.47057539136334 no 1811 0.473588899144231 2615 1609 A potent and irreversible inhibitor of serine proteases. SGTC_576 1073-0113 22.7 µM -0.0662987794301267 0.470556706081756 no 1812 0.473569977481156 2529 5439563 SGTC_2459 5811157 9.22 µM -0.0692754156852432 0.469386738501135 no 1813 0.472385197078104 2519 2870684 YBR192W RIM2 SGTC_1821 st053465 65.6 µM -0.0693003343662929 0.469376945309067 no 1814 0.472375279796746 2579 675086 SGTC_2153 5569715 200 µM -0.0703481204881181 0.468965175878675 no 1815 0.471958291368363 2529 2054701 SGTC_2977 9011197 71.43 µM -0.0704199615552066 0.468936944271297 no 1816 0.471929701832055 2717 2704722 SGTC_420 mitomycin C 81.9 mM -0.0716407290079039 0.468457239483915 no 1817 0.471443913135027 2531 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0725829099295345 0.468087037510255 no 1818 0.471069013372594 2525 229346 A bile salt which induces apoptosis. SGTC_2838 9002687 71.43 µM -0.0738241850958476 0.46759935752658 no 1819 0.470575141303904 2536 6457060 SGTC_2742 clothiapine 36.27 µM -0.0742835958317534 0.467418873641498 no 1820 0.470392364797848 2530 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_922 1866-0035 480 µM -0.0754024751515945 0.466979339334171 no 1821 0.469947244965982 2547 3156169 SGTC_2886 9058944 51.95 µM -0.0755553957555324 0.466919269973106 no 1822 0.469886412003438 2526 4949929 SGTC_1495 4469-0029 237 µM -0.0756177074951093 0.466894793262582 no 1823 0.469861624127814 2538 793680 SGTC_666 0272-0154 136 µM -0.0759870369528238 0.466749719317504 no 1824 0.469714705696117 2562 6870312 SGTC_1372 2752-0194 270 µM -0.0773023156425923 0.466233109107064 no 1825 0.469191524402624 2547 823334 SGTC_847 0342-0274 5.54 µM -0.0782779023851139 0.465849958519741 no 1826 0.468803497430091 2585 18097 SGTC_427 1354-0053 47.3 µM -0.0782812708910088 0.465848635632026 no 1827 0.468802157701685 2785 6813657 SGTC_716 1683-5115 658 µM -0.0783306665978087 0.465829236874917 no 1828 0.468782511990231 2527 723597 SGTC_2664 lyso-paf C-16 73.48 µM -0.0783956915097306 0.465803700316397 no 1829 0.468756650331099 2547 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2671 danthron 100 µM -0.0784771852098128 0.465771696340518 no 1830 0.468724238904069 2575 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3215 9129942 49.47 µM -0.0785471914074933 0.465744203880907 no 1831 0.468696396417131 2577 17682944 SGTC_1697 st025554 27.742 µM -0.0787946998828667 0.46564700498762 no 1832 0.468597959911172 2539 1269519 SGTC_451 chloral hydrate 100 µM -0.0789070373119246 0.465602889704308 no 1833 0.46855328286604 2636 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1208 2323-2347 50.3 µM -0.0801131826920825 0.465129259131889 no 1834 0.468073619088414 2567 5412760 SGTC_1223 0764-0573 147 µM -0.0801140822793179 0.465128905899277 no 1835 0.468073261354877 2559 1609797 SGTC_3201 9113999 49.47 µM -0.080146821468371 0.46511605052297 no 1836 0.468060242172668 2711 16649224 SGTC_2270 7924575 90.91 µM -0.0804565175525662 0.464994447001621 no 1837 0.467937089019713 2707 1262135 SGTC_2689 tacrolimus 100 µM -0.0805105767751069 0.464973220746369 no 1838 0.467915592246831 2638 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2436 5633522 8.09 µM -0.0811481369771191 0.464722891430159 no 1839 0.467662072056888 2572 5724242 SGTC_1224 0823-0416 294 µM -0.0844788881100052 0.463415346684469 no 1840 0.466337843838854 2645 3598164 SGTC_2047 4141938 200 µM -0.0846320934114094 0.463355212654914 no 1841 0.466276941869513 2579 3807862 SGTC_2763 lisinopril 49.32 µM -0.0852110762599681 0.463127965873948 no 1842 0.466046792514049 2535 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_6 0844-0013 19.835 µM -0.0855115625487268 0.463010031812778 no 1843 0.465927351778625 2587 1584900 SGTC_3284 9108171 64.8615 µM -0.0861564484553207 0.462756939692582 no 1844 0.465671025509061 2628 8687505 SGTC_47 0149-0135 24.25 µM -0.0863192907672254 0.462693032929115 no 1845 0.465606301947499 2530 5239155 SGTC_2445 5742597 35.57 µM -0.0865529512646564 0.462601335556518 no 1846 0.465513432468183 2579 1774255 SGTC_1889 st059080 5.18 µM -0.0875783225116518 0.462198963974979 no 1847 0.465105916047125 2544 176925 Isolated from Daphnopsis sellowiana. SGTC_3234 9132280 49.47 µM -0.0883118693583945 0.46191113252542 no 1848 0.464814402716012 2630 17612295 SGTC_624 k048-0052 28 µM -0.0904689740038047 0.46106483706324 no 1849 0.463957273992088 2616 6835531 SGTC_306 1672-3436 11.6 µM -0.0912170631561782 0.460771380710801 no 1850 0.463660058518755 2641 6797378 SGTC_898 1000-0849 28.3 µM -0.0921844581979281 0.46039192793117 no 1851 0.463275743011613 2533 6751807 SGTC_876 0720-0963 56.8 µM -0.0925834079377275 0.460235453648276 no 1852 0.463117262836361 2624 765861 SGTC_344 k064-0035 6.43 µM -0.093138644765828 0.460017691396595 no 1853 0.462896708385082 2583 5088750 SGTC_2925 9010536 32.5 µM -0.0942987187019694 0.459562752588606 no 1854 0.462435933854498 2637 2994177 SGTC_1591 genipin 88.4 µM -0.0943523581300135 0.459541718431707 no 1855 0.462414629804219 2730 442424 A DNA cross-linking agent. SGTC_755 1995-0008 37.3 µM -0.0947861350054753 0.459371621401821 no 1856 0.462242349973449 2565 689533 SGTC_452 diindolylmethane 8 µM -0.0949968281371043 0.459289004935238 no 1857 0.462158673154031 2659 3071 Inhibits expression of several cancer promoting factors. SGTC_3244 9134489 49.47 µM -0.0957776447166861 0.458982848439021 no 1858 0.461848586326164 2645 16584271 SGTC_1954 st077032 68.9 µM -0.0984763829849138 0.457924867460812 no 1859 0.46077701222126 2670 698907 SGTC_1701 st028638 40.4 µM -0.0993792337003693 0.457570990859976 no 1860 0.460418585119628 2582 3490878 SGTC_2589 lobaric acid 100 µM -0.101658971678481 0.456677587116024 no 1861 0.459513684612398 2638 73157 A novel microtubule depolymerizer. SGTC_3083 9117465 49.47 µM -0.101676530432814 0.456670706881003 no 1862 0.459506715792151 2681 16420915 SGTC_2452 5863136 48.41 µM -0.102559973559817 0.456324554697408 no 1863 0.459156105866264 2575 2184096 SGTC_2564 betulinic acid 100 µM -0.103904990710467 0.455797611525803 no 1864 0.458622373267106 2670 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_717 1532-0246 73.2 µM -0.1039771572057 0.455769340735962 no 1865 0.458593738103011 2643 9561992 SGTC_1415 3966-0071 78.1 µM -0.107197794165044 0.454507905717272 no 1866 0.457316032674365 2612 2893185 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.107407125616056 0.454425932076518 no 1867 0.457233000893058 2845 6710655 SGTC_1182 1222-0449 220 µM -0.107531047301734 0.454377405587657 no 1868 0.457183847962831 2661 658318 SGTC_1899 st063254 59.6 µM -0.107609659687735 0.454346622118939 no 1869 0.457152667084099 2580 3093813 SGTC_2628 lathosterol 100 µM -0.108090600204439 0.454158298774329 no 1870 0.456961912208771 2707 6710616 SGTC_2277 7947813 106.88 µM -0.108501985140082 0.453997219696626 no 1871 0.456798752949333 2836 1246798 SGTC_2157 5649910 96.377 µM -0.109904437150083 0.453448142183066 no 1872 0.456242581763806 2613 2858091 SGTC_1156 4092-0367 4.88 µM -0.11012247588671 0.45336278525449 no 1873 0.456156121690899 2618 1357585 SGTC_2496 diffractaic acid 79.83 µM -0.111438308698837 0.4528477141858 no 1874 0.455634391640526 2712 94870 An apoptosis inducer which activates caspases. SGTC_3118 9124250 49.47 µM -0.111611897163541 0.452779770427048 no 1875 0.45556556919783 2677 1504786 SGTC_1293 1000-1278 195 µM -0.111689057784278 0.452749569655456 no 1876 0.455534977832671 2693 678847 SGTC_937 3122-0005 46.7 µM -0.11193315458002 0.452654031639488 no 1877 0.455438204114289 2661 759535 SGTC_3265 9137266 49.47 µM -0.112542357278716 0.452415605340203 no 1878 0.455196693398112 2573 17224265 SGTC_1547 harmine 94.2 µM -0.11258464976594 0.452399053782197 no 1879 0.455179927689291 2608 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3330 9141424 71.43 µM -0.112900136608556 0.45227558768573 no 1880 0.455054864013125 2721 27261020 SGTC_2863 9028737 58.44 µM -0.115623124897397 0.451210136511272 no 1881 0.453975617402879 2737 6460917 SGTC_3157 9099274 49.47 µM -0.117532552988513 0.450463224406223 no 1882 0.453219024623873 2638 17217662 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.120104094885235 0.449457590512437 no 1883 0.452200344312808 2588 4000243 SGTC_1165 k072-0275 30.3 µM -0.120831650234087 0.449173129436188 no 1884 0.451912190252728 2628 6153523 YGL055W OLE1 SGTC_2506 ethyl hematommate 54.16 µM -0.123444663920417 0.448151704416708 no 1885 0.450877495409122 2686 3940691 An allergen. SGTC_1107 amlodipine 47 µM -0.123833668808185 0.447999671932886 no 1886 0.450723486562348 2657 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2723 salbutamol 83.58 µM -0.124069846130948 0.44790737186906 no 1887 0.45062998647823 2710 9884233 β2-adrenoceptor agonist SGTC_217 ketoconazole 989 nM -0.124345787215836 0.447799535368979 no 1888 0.450520747815474 2681 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2803 7707263 71.43 µM -0.124585782384273 0.447705749503387 no 1889 0.450425742352944 2655 2199229 SGTC_1978 st071761 42 µM -0.124726672521669 0.447650693492003 no 1890 0.450369970333625 2644 5147680 SGTC_179 1273-0063 6.77 µM -0.125516583576717 0.44734203656978 no 1891 0.450057298532761 2642 3108139 SGTC_3101 9120531 49.47 µM -0.126214113210195 0.447069504097665 no 1892 0.449781219989588 2784 24824904 SGTC_1307 1187-1599 12.2 µM -0.126600578192897 0.44691851874491 no 1893 0.4496282696463 2629 1538471 SGTC_1717 st033143 58.0435 µM -0.126626595907993 0.446908354338459 no 1894 0.449617972944582 2717 674616 SGTC_1977 st070720 65.3 µM -0.127217434983959 0.446677539146456 no 1895 0.449384153189124 2739 682188 SGTC_1025 k007-0731 70 µM -0.128275572417204 0.4462642159534 no 1896 0.448965447885688 2626 6256118 SGTC_1703 st026983 48.3 µM -0.128482427026296 0.446183422474787 no 1897 0.448883602080197 2667 1104023 SGTC_1154 4088-0362 150 µM -0.129158030450211 0.445919560201513 no 1898 0.448616302413743 2624 6618304 SGTC_542 3381-0244 89.3 µM -0.129931420689784 0.445617535918383 no 1899 0.448310342441642 2809 1112843 SGTC_1340 1486-1359 257 µM -0.130053489821109 0.445569868371794 no 1900 0.448262053625624 2683 4309068 SGTC_1792 st045773 43.6 µM -0.130111804249628 0.445547097079726 no 1901 0.448238985535807 2632 2919270 SGTC_1552 6-methylflavone 10.6 µM -0.130203093080203 0.445511449922763 no 1902 0.448202873744961 2636 689013 SGTC_2309 7664088 163.95 µM -0.130590620221715 0.445360130284402 no 1903 0.448049581579372 2670 704922 SGTC_2858 9025781 8.96 µM -0.131405811531652 0.445041844514782 no 1904 0.447727145795989 2730 4894980 YPL153C RAD53 SGTC_737 1950-0117 57.9 µM -0.131930566665864 0.44483697625675 no 1905 0.44751960561956 2664 5393513 SGTC_2729 fluphenazine 10.66 µM -0.132787906381642 0.444502296260491 no 1906 0.447180559483005 2662 3372 An atypical antipsychotic. SGTC_117 lucigenin 22.078 µM -0.133265737566367 0.444315782293651 no 1907 0.446991611663466 2668 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_213 1246-0773 967 nM -0.135570140648185 0.443416468264353 no 1908 0.446080555893696 2667 6251622 SGTC_604 1000-0114 314 µM -0.135615706217611 0.443398688813427 no 1909 0.446062544201362 2729 1572745 SGTC_1807 st050092 58.9 µM -0.137494744702403 0.442665597307882 no 1910 0.445319873207924 2665 5008496 SGTC_2229 7354935 190 µM -0.139064826152204 0.442053193262755 no 1911 0.444699461382328 2654 318112 SGTC_2514 salinomycin 42.74 µM -0.13928900570222 0.441965764180888 no 1912 0.444610888685215 2783 23682228 A polyether potassium ionophore. SGTC_2552 juarezic acid 87.02 µM -0.13931852990744 0.441954250075581 no 1913 0.444599223962439 2622 1549512 SGTC_157 1348-1695 65.819 µM -0.140165879757117 0.44162381418098 no 1914 0.444264464868489 2660 5380510 SGTC_1678 st019265 80.2 µM -0.14050166137608 0.441492882680438 no 1915 0.444131819961738 2754 5367020 SGTC_2173 5763948 167 µM -0.142713510243486 0.440630575724368 no 1916 0.443258223155423 2651 2867177 SGTC_2170 morpholine 200 µM -0.146052947163503 0.439329204073232 no 1917 0.441939795364261 2770 121171 Reacts with secondary amines. SGTC_432 NS 1619 61.3 µM -0.146735592403168 0.439063258864392 no 1918 0.441670361996333 2834 4552 A K+/calcium channel activator. SGTC_2065 5221596 34.26 µM -0.146764498569594 0.439051998194529 no 1919 0.441658953611208 2778 788581 SGTC_2152 5568786 200 µM -0.147283331635384 0.438849890275267 no 1920 0.441454194212387 2644 5399883 SGTC_83 0170-0301 39.027 µM -0.147671505322478 0.438698690258253 no 1921 0.441301010252281 2655 3089716 SGTC_1675 st018485 24.5 µM -0.147740279213649 0.438671902632031 no 1922 0.441273871107692 2754 3323024 SGTC_3307 9126885 69.2785 µM -0.147965656240233 0.438584119608581 no 1923 0.441184936096807 2673 24824909 SGTC_2966 9084041 48.03 µM -0.148230743847445 0.438480873414947 no 1924 0.441080334868955 2633 17741380 SGTC_2755 lomerizine 42.69 µM -0.148444915999226 0.438397460805674 no 1925 0.440995827431455 2713 3949 A calcium channel blocker. SGTC_1177 0983-0204 23.6 µM -0.14853851857708 0.438361006713977 no 1926 0.440958894836411 2773 766818 SGTC_2892 9047358 58.44 µM -0.149013909204094 0.43817587103023 no 1927 0.440771328774151 2723 6466771 SGTC_2596 sinensetin 100 µM -0.152584991471653 0.436785587389061 no 1928 0.43936278073207 2732 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.152671776913107 0.436751809970887 no 1929 0.439328559282186 2663 66535 A nucleotide analog. SGTC_323 4013-0906 34.3 µM -0.153569348710484 0.436402496694779 no 1930 0.43897465319239 2794 2910086 SGTC_2297 7971671 152.32 µM -0.153661997905703 0.436366442683655 no 1931 0.438938125055207 2816 909016 SGTC_2278 7948257 134.34 µM -0.154159838547235 0.436172719332142 no 1932 0.438741853889765 2711 1247028 SGTC_2739 tacrine 100.86 µM -0.154988946145404 0.435850124990201 no 1933 0.438415015850024 2770 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_889 0919-1524 82.7 µM -0.155199319339225 0.43576827845883 no 1934 0.438332092437847 2752 3905452 SGTC_1359 1582-0056 520 nM -0.156565143515976 0.435236966168461 no 1935 0.437793787567151 2791 3661189 SGTC_340 k038-0059 454 µM -0.156706218362382 0.435182094007319 no 1936 0.437738193045061 2673 23733424 SGTC_694 1315-0438 43.2 µM -0.157068055126137 0.435041360486396 no 1937 0.437595606684394 2733 6793154 SGTC_742 0kpi-0133 140 µM -0.158583975766869 0.43445184490788 no 1938 0.436998327251979 2839 2728852 SGTC_2627 acetyl isogambogic acid 100 µM -0.159050474930779 0.434270460632131 no 1939 0.436814553345954 2785 6857789 A caspase activator and apoptosis inducer. SGTC_2850 9015429 58.44 µM -0.159444072649742 0.434117432667997 no 1940 0.43665950903034 2749 6457570 SGTC_346 4513-0042 7.16 µM -0.159789778061045 0.433983033031816 no 1941 0.436523338271141 2702 2827372 SGTC_3126 9127922 49.47 µM -0.160569332399716 0.433679994300223 no 1942 0.436216305314366 2954 45595682 SGTC_2409 alverine citrate 63.97 µM -0.160683541013026 0.433635600878437 no 1943 0.436171326672244 2967 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3231 9132313 49.47 µM -0.161838945786759 0.433186536813188 no 1944 0.435716341498466 2746 4905967 SGTC_2215 7188065 200 µM -0.162037765823566 0.4331092713349 no 1945 0.435638057006237 2821 940217 SGTC_1677 st019204 53.9 µM -0.163119899834745 0.432688777128141 no 1946 0.435212015920227 2805 3945625 SGTC_1981 st071826 47 µM -0.163523865528723 0.43253182418219 no 1947 0.435052992036993 2800 11838600 SGTC_2878 9043973 25.97 µM -0.163693018705119 0.432466106194238 no 1948 0.434986406840491 2870 6465167 SGTC_1627 st003713 25.6 µM -0.16453032054683 0.432140832179381 no 1949 0.434656839815627 2781 16195070 YER133W GLC7 SGTC_1857 st056007 79.3 µM -0.166319240872124 0.43144602893424 no 1950 0.433952862449895 2781 619834 SGTC_2824 7998404 51.95 µM -0.168882321861504 0.430450917569421 no 1951 0.432944602285313 2701 837851 SGTC_2379 9035213 200 µM -0.169558340461832 0.430188527944581 no 1952 0.432678743767595 2781 646551 SGTC_271 rotenone 740 µM -0.169760315229809 0.430110139503691 no 1953 0.432599318853388 2839 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2607 solasodine 47.35 µM -0.171935123562147 0.429266249637119 no 1954 0.431744266567255 2748 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1174 0739-0097 51.1 µM -0.172128716870053 0.429191145323454 no 1955 0.431668168445588 2774 728447 SGTC_2415 st077333 57.7 µM -0.173305530274783 0.428734657086921 no 1956 0.431205638469286 2891 2766255 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.173719911124432 0.428573940599028 no 1957 0.431042794319786 2780 6857784 SGTC_473 2-arachidonoylglycerol 10 µM -0.176409239672251 0.42753118085024 no 1958 0.429986223145417 2690 5282280 An endocannabinoid. SGTC_1447 4239-0816 81.9 µM -0.177827328511833 0.4269815346476 no 1959 0.429429292176342 2729 1341554 SGTC_1109 tnp00067 928.257 nM -0.177837015439203 0.426977780515129 no 1960 0.429425488277283 2745 676295 SGTC_2490 carminic acid 95.39 µM -0.178194306196957 0.426839318441887 no 1961 0.429285190580348 2676 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_51 1013-0126 23.419 µM -0.178584000562689 0.426688309169165 no 1962 0.429132179112793 2889 1627850 SGTC_566 0958-0068 16.5 µM -0.179524599072101 0.426323865024925 no 1963 0.428762901907906 2876 6815365 SGTC_3321 9137793 26.8275 µM -0.180215360876145 0.426056262612949 no 1964 0.428491749814128 2720 4904192 SGTC_270 tamoxifen 5.46 µM -0.180331674275445 0.426011205930752 no 1965 0.428446095392494 2896 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2191 5911152 200 µM -0.181412321676107 0.425592638445805 no 1966 0.428021974021979 2757 2875902 SGTC_1378 2093-0007 380 nM -0.184463464613639 0.42441129234614 no 1967 0.426824943159362 2838 3618014 SGTC_3287 9117173 37.0625 µM -0.184835498909897 0.424267293763022 no 1968 0.426679031729925 2751 2789709 SGTC_2708 st078559 56 µM -0.184965860897269 0.424216838597388 no 1969 0.426627906278993 2763 17250902 SGTC_1360 1598-0022 39.8 µM -0.185052374386452 0.42418335519366 no 1970 0.426593978041713 2833 761525 SGTC_2362 9071156 126 µM -0.185205875453772 0.424123946866442 no 1971 0.426533780435379 2908 653133 SGTC_478 N-arachidonylglycine 10 µM -0.185663624587267 0.423946798012297 no 1972 0.426354277829421 2724 5283389 SGTC_1239 0337-0584 35.4 µM -0.185882057040677 0.423862270095542 no 1973 0.426268626690702 2895 914301 YML130C ERO1 SGTC_364 0083-0097 67.7 µM -0.186515336014034 0.423617226725443 no 1974 0.42602032673487 2876 5207356 SGTC_989 1501-0895 10.3 µM -0.187020278764365 0.42342186342016 no 1975 0.425822366652382 2752 2830112 SGTC_2057 5236571 38.335 µM -0.188002111965781 0.423042044227435 no 1976 0.425437497796656 2863 54684039 YBR257W POP4 SGTC_365 0121-0052 13.6 µM -0.188081146055303 0.423011473235429 no 1977 0.425406520303556 2868 3101739 SGTC_1880 MG-132 525 µM -0.18846392415644 0.422863418293011 no 1978 0.425256496550082 2830 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1974 st069448 26.9 µM -0.189427278128325 0.422490850363049 no 1979 0.424878973311587 2871 6323587 YNR016C ACC1 SGTC_1320 1313-0481 95.3 µM -0.189460007914809 0.422478193647253 no 1980 0.424866148232153 2861 6813365 YLR208W SEC13 SGTC_2081 5214970 32.255 µM -0.19043430361459 0.42210146701427 no 1981 0.424484409541576 2807 2063512 SGTC_2828 7998861 71.43 µM -0.190446238522163 0.422096852637182 no 1982 0.424479733765129 2824 2988188 SGTC_611 3453-1652 23.7 µM -0.191931637289862 0.421522638618354 no 1983 0.423897877576362 2826 1560575 SGTC_2036 5160441 105 µM -0.192388322968293 0.42134613006182 no 1984 0.423719019237353 2797 134534 YIL048W NEO1 SGTC_2149 5554786 194.827 µM -0.192488958800014 0.421307236537728 no 1985 0.423679607899979 2761 745063 YPR165W RHO1 SGTC_2389 9091542 195.52 µM -0.19437471270038 0.420578576747161 no 1986 0.422941244323977 2809 3626624 YOL127W RPL25 SGTC_1230 0170-0365 3.77 µM -0.194732405314351 0.42044039409062 no 1987 0.422801220873024 2844 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_664 1222-0054 14.9 µM -0.196761699589735 0.419656629752594 no 1988 0.422007012221904 2777 6813991 SGTC_175 3793-3120 23.7 µM -0.198708338483422 0.418905088338875 no 1989 0.421245450466337 2779 5322297 SGTC_2349 9023730 187.07 µM -0.199305945081491 0.41867442880545 no 1990 0.421011714482082 2887 4126287 SGTC_2440 5628896 157.78 µM -0.199326868874508 0.418666353309136 no 1991 0.421003531268883 2775 5522048 SGTC_31 0508-1974 57.237 µM -0.199463924113341 0.41861345795991 no 1992 0.420949930347833 2835 6810525 SGTC_3260 9137109 49.47 µM -0.199800928623283 0.418483400083372 no 1993 0.420818137517527 2866 17478346 SGTC_1941 st076221 61.8 µM -0.200371283009953 0.418263307372921 no 1994 0.420595108446225 2926 2828568 SGTC_2568 diosmetin 100 µM -0.202219343225467 0.41755033990741 no 1995 0.419872625898326 2832 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1028 k015-0029 4.8 µM -0.203572152137011 0.417028608230188 no 1996 0.419343928397343 2749 4588309 SGTC_1756 st041558 35.5 µM -0.205278805681662 0.416370619394272 no 1997 0.418677151033438 2939 3955792 SGTC_177 1327-0068 8.361 µM -0.20555988966259 0.416262271771358 no 1998 0.418567355878853 2762 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_773 4358-1457 44.6 µM -0.206327380481563 0.415966464481877 no 1999 0.418267596054053 2859 1186886 SGTC_85 0868-0259 160.055 µM -0.206546094764399 0.415882176052411 no 2000 0.418182181232945 2837 83173 SGTC_935 2996-0153 430 µM -0.208503259478993 0.415128093735769 no 2001 0.417418018934598 2931 23738523 SGTC_3346 9158254 43.5805 µM -0.208558419105391 0.415106845620726 no 2002 0.417396486719485 2868 17639500 SGTC_1641 st009299 47.1 µM -0.208854724862061 0.414992709526415 no 2003 0.417280824489899 2779 4046054 SGTC_2516 gossypol 71.55 µM -0.209019182288718 0.41492936411134 no 2004 0.417216632022561 2929 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2883 9059145 45.46 µM -0.209220261468022 0.414851915801118 no 2005 0.417138148029534 2735 16476510 SGTC_1033 k072-0102 21.3 µM -0.210149912821983 0.414493891328777 no 2006 0.41677533517752 2952 5965931 SGTC_1001 4048-4355 44.4 µM -0.210551570154643 0.414339228246817 no 2007 0.41661860322116 2784 21824233 SGTC_2614 arthonioic acid 13.39 µM -0.210704246841863 0.414280441698442 no 2008 0.416559030251736 2745 6710684 SGTC_430 0958-0115 16.4 µM -0.210920169051151 0.414197306407307 no 2009 0.416474782762109 2808 6833180 SGTC_1634 st006576 41 µM -0.211331575424806 0.414038915611985 no 2010 0.416314272823607 2935 3915356 SGTC_2488 5268135 45.7 µM -0.211992675984726 0.413784422250043 no 2011 0.416056374095031 2903 1270356 YLR208W SEC13 SGTC_1253 0550-0034 176 µM -0.212333290997659 0.413653315235195 no 2012 0.415923512527364 2899 5969915 SGTC_2898 9056270 58.44 µM -0.214406302057118 0.412855595199709 no 2013 0.415115113802413 2753 19154699 SGTC_385 1494-0393 12.4 µM -0.214516937857532 0.412813031272044 no 2014 0.415071979942457 2833 3090647 SGTC_1960 st011366 51.8 µM -0.2151704195451 0.412561643997904 no 2015 0.414817226277809 2761 3972846 SGTC_1834 st055981 52.8 µM -0.216842180033349 0.41191869943768 no 2016 0.414165669508076 2942 471719 YDL150W RPC53 SGTC_2476 5806916 10.51 µM -0.217297504724918 0.411743626402701 no 2017 0.4139882507909 2809 2870194 SGTC_516 3992-2719 87.3 µM -0.217352042547269 0.411722657704701 no 2018 0.413967001131073 2731 5350887 YDR037W KRS1 SGTC_1127 asiatic acid 681.4 nM -0.21840131646782 0.411319282094385 no 2019 0.413558219951715 2770 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1462 k081-0014 26.5 µM -0.220007842370999 0.410701862135637 no 2020 0.412932523505675 2819 3270634 SGTC_1113 artemisinin 1.17947 µM -0.220843643762752 0.410380734363556 no 2021 0.412607089823274 2896 2240 An anti-malaria and mitochondrial poison. SGTC_1441 4106-0040 13 µM -0.221805951294267 0.410011075400898 no 2022 0.41223247319591 2791 2904180 SGTC_1681 tripelennamine 100 µM -0.223066839834806 0.409526841171376 no 2023 0.411741743052256 2777 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2406 ethylparaben 405.7 µM -0.223120653454782 0.409506177543141 no 2024 0.411720802184361 2758 8434 A possible steroid mimic. SGTC_1438 4092-1045 4 µM -0.22434191329957 0.409037299657208 no 2025 0.411245632567347 2803 1351342 SGTC_2327 6189656 200 µM -0.225219419836972 0.408700479163874 no 2026 0.410904291331813 2930 5349088 SGTC_2375 9072683 200 µM -0.225466211004679 0.408605763432938 no 2027 0.410808304186808 2949 16798029 SGTC_1281 0884-0031 11.8 µM -0.225584024443499 0.408560549815248 no 2028 0.4107624836211 2803 1548255 SGTC_1881 5652484 16 µM -0.229062885201085 0.40722600800985 no 2029 0.409410019932574 2946 2255129 SGTC_1226 3909-7979 35.4 µM -0.229414903236501 0.407091028453786 no 2030 0.409273226959445 2927 6615510 SGTC_3127 9126946 49.47 µM -0.230297185702442 0.406752770169083 no 2031 0.408930423665236 2896 27243249 SGTC_2716 st080858 38.6235 µM -0.230719605629532 0.406590843195965 no 2032 0.40876632066077 2947 5296050 SGTC_3336 9143619 71.43 µM -0.230895503941694 0.406523420494986 no 2033 0.408697991853162 2840 45595730 SGTC_3176 9106582 49.47 µM -0.231793282603246 0.406179340660411 no 2034 0.408349287345921 2869 17018027 SGTC_1139 k015-0024 46.9 µM -0.232083660884849 0.406068066683551 no 2035 0.408236517584747 2898 2766652 SGTC_475 α-linolenic acid 10 µM -0.232599763271731 0.405870313169411 no 2036 0.408036105576122 3051 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1393 3470-5649 58.2 µM -0.233294644958743 0.405604095234299 no 2037 0.407766308300926 2899 4108395 SGTC_1588 farnesol 29.9 µM -0.233352634762266 0.405581880581431 no 2038 0.407743794945672 2824 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3029 9088683 49.47 µM -0.234508537712024 0.405139142429581 no 2039 0.40729510291729 2966 25236615 SGTC_1456 k015-0012 13 µM -0.235153927156757 0.404891995783714 no 2040 0.407044632073572 2856 2989616 SGTC_681 1642-0006 26.6 µM -0.235372459402586 0.404808319226773 no 2041 0.406959829943465 2846 4446530 SGTC_3296 9122258 64.045 µM -0.236763166971869 0.404275915876369 no 2042 0.406420263829599 2919 4730474 SGTC_802 4112-3352 742 µM -0.23700087740939 0.404184931108377 no 2043 0.406328054786947 2976 704594 SGTC_2720 fluspirilene 36.88 µM -0.237325348158591 0.404060746796241 no 2044 0.406202199380191 2918 3396 An atypical antipsychotic. SGTC_2830 7992007 71.43 µM -0.239196992428819 0.403344603661935 no 2045 0.405476417340543 2709 1952075 SGTC_190 3970-0790 3.722 µM -0.239298395874745 0.403305813115661 no 2046 0.405437104593801 2877 2832352 SGTC_2518 prenyletin 46.28 µM -0.239554382215284 0.403207893161934 no 2047 0.405337866390694 2946 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2881 9058953 51.95 µM -0.240343351804605 0.402906134536033 no 2048 0.405032044923927 2790 17122249 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.24071598452985 0.402763633116737 no 2049 0.404887624669252 2926 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_687 k029-0044 34.9 µM -0.241058465742284 0.402632673565761 no 2050 0.404754901578077 2975 5829338 SGTC_2435 5706476 10.6 µM -0.241360714381971 0.402517107406758 no 2051 0.404637779075349 2987 5725375 SGTC_2254 7938975 95.19 µM -0.241456255835752 0.402480578463486 no 2052 0.404600758173706 3039 2969277 SGTC_2220 6782180 200 µM -0.241961371428913 0.402287468714203 no 2053 0.404405047545436 2865 833803 SGTC_419 nsc-638432 893 µM -0.242866365320015 0.401941541940849 no 2054 0.404054461073458 2910 368090 SGTC_2692 st077426 47.7 µM -0.242879837624621 0.401936392838254 no 2055 0.404049242605508 3004 25238571 SGTC_1813 st051246 8.6015 µM -0.242966342266508 0.401903331248181 no 2056 0.404015735627073 2916 5291959 SGTC_886 0866-0150 153 µM -0.242996166381658 0.401891932800977 no 2057 0.404004183624311 3027 271463 SGTC_2305 7443522 69.23 µM -0.243080014884621 0.401859887276949 no 2058 0.403971706390552 2837 5415886 SGTC_1009 4106-0057 9.87 µM -0.243563751490387 0.401675023961952 no 2059 0.403784352508885 2858 2928005 SGTC_1854 st056233 32.9 µM -0.243710607521149 0.401618906257878 no 2060 0.403727478716024 2866 5393174 SGTC_121 0557-0495 61.343 µM -0.245158016503939 0.40106592042641 no 2061 0.403167041261906 2834 3104427 SGTC_698 k064-0052 127 µM -0.245392332334546 0.400976418146579 no 2062 0.403076332730199 2814 5088751 SGTC_347 4534-1311 26.2 µM -0.245659160901751 0.400874503213909 no 2063 0.40297304419343 2800 2862016 SGTC_1839 st053978 48 µM -0.246651373169749 0.400495587860866 no 2064 0.402589021255596 2916 3788398 SGTC_2291 7917025 104.35 µM -0.24737488758862 0.40021934437467 no 2065 0.402309053572714 2830 2964612 SGTC_1180 1193-0155 285 µM -0.249482261292826 0.399415017441899 no 2066 0.401493880315551 2987 2921347 SGTC_1568 digitonin 820 nM -0.250920824800327 0.398866201944419 no 2067 0.400937661755664 2999 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2528 xanthyletin 44.79 µM -0.252416152252329 0.398295942742471 no 2068 0.400359708288526 2850 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1602 st001878 87.6 µM -0.25472616729592 0.397415420876593 no 2069 0.399467302090314 3033 595405 YLR310C CDC25 SGTC_1759 st043059 70 µM -0.254971514655382 0.397321931013497 no 2070 0.399372550133255 2860 669426 SGTC_1132 3456-3614 2.5 µM -0.255897560123812 0.396969113629028 no 2071 0.399014969327253 3124 3125502 SGTC_2136 5328288 199.296 µM -0.256036814171887 0.396916066015261 no 2072 0.398961205450033 2893 262395 SGTC_2387 9077560 195.08 µM -0.256106166556448 0.396889647541342 no 2073 0.398934430260551 2857 5303272 SGTC_1766 st045414 44.774 µM -0.256162694597704 0.396868114607511 no 2074 0.398912606575203 2850 253960 SGTC_3171 9103192 49.47 µM -0.257411715209049 0.396392412002739 no 2075 0.398430480048061 2932 13018434 SGTC_2841 9004761 38.96 µM -0.258801379430035 0.395863325045434 no 2076 0.39789424674884 2886 2991039 SGTC_559 1550-0661 158 µM -0.25901298322855 0.395782777919368 no 2077 0.39781261153982 2939 5830875 SGTC_910 3454-3003 490 µM -0.260059525935137 0.395384476242423 no 2078 0.397408928812693 2969 820824 SGTC_849 0386-0493 241 µM -0.260812078270283 0.395098131300982 no 2079 0.397118714812117 2873 726119 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.261078616621362 0.394996727466642 no 2080 0.397015940713058 2961 616764 SGTC_2541 muurolladie-3-one 83.07 µM -0.261537621501738 0.394822116905654 no 2081 0.396838970516971 3040 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.261791407223099 0.394725583061374 no 2082 0.396741132071816 2846 803109 SGTC_3080 9117754 49.47 µM -0.262157854772789 0.394586206834928 no 2083 0.396599872164526 3079 9550191 SGTC_3013 9080133 71.4286 µM -0.263131854924798 0.394215817092776 no 2084 0.39622447606654 3074 17050193 SGTC_1501 4491-0275 38.4 µM -0.263649586547385 0.394018974634143 no 2085 0.396024972697142 2914 5104718 SGTC_2273 7815444 169.05 µM -0.263935524412425 0.393910272163871 no 2086 0.395914800701701 3051 2824616 SGTC_596 1155-0152 116 µM -0.265092673479702 0.393470453518804 no 2087 0.39546903560734 2893 280313 SGTC_76 0433-0009 400.328 µM -0.265644980994573 0.393260575855261 no 2088 0.395256319992703 2992 2841569 SGTC_1995 st072814 61.1 µM -0.265992584313513 0.393128501984802 no 2089 0.395122460111391 2883 5769371 SGTC_2469 5655019 90.81 µM -0.267846396250457 0.392424343597232 no 2090 0.394408778006995 3000 2788239 SGTC_2351 9026858 72.31 µM -0.268378302010802 0.392222367555751 no 2091 0.39420406978224 2853 1409300 SGTC_880 0833-0487 87.2 µM -0.268626588582826 0.392128097747378 no 2092 0.394108524691132 2873 76075 SGTC_750 4073-0104 132 µM -0.269538948343391 0.391781746076956 no 2093 0.393757487191936 2955 22330957 SGTC_1975 st070967 30.8 µM -0.270752812991964 0.391321069553122 no 2094 0.393290577208213 3029 261391 SGTC_246 cycloheximide 667 µM -0.270803117243826 0.391301981756944 no 2095 0.39327123111076 2869 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3164 9100705 49.47 µM -0.272728385068856 0.390571641840592 no 2096 0.392531006714118 3042 17174235 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.276816490071698 0.389022123997784 no 2097 0.390960509266194 2867 364106 SGTC_303 1348-1668 34.2 µM -0.276944054901706 0.388973801240115 no 2098 0.390911532068847 2915 5380509 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.280090203499993 0.38778255583513 no 2099 0.389704150251054 3085 688798 SGTC_660 4031-1742 102 µM -0.28086149875603 0.387490676271862 no 2100 0.389408315997068 2888 6738706 SGTC_2147 5545932 89.7195 µM -0.28132697810127 0.387314556702537 no 2101 0.389229810000005 2934 797404 SGTC_65 0798-0905 34.986 µM -0.281704652692625 0.38717167613135 no 2102 0.389084993294966 3299 3602145 SGTC_2285 7945142 200 µM -0.283693651909544 0.386419457333125 no 2103 0.388322579996625 3016 2970608 SGTC_2730 imipramine 71.33 µM -0.284590325154314 0.386080484195347 no 2104 0.38797901214538 2920 3696 A tricyclic antidepressant. SGTC_1151 3909-8316 15.3 µM -0.285039510279292 0.385910709534363 no 2105 0.387806936049268 3024 800431 SGTC_466 geldanamycin 89.2 µM -0.285494545385482 0.385738746083677 no 2106 0.38763264137576 2966 5288382 HSP90 inhibitor. SGTC_2605 digitonin 300 nM -0.285612142178982 0.385694308436375 no 2107 0.387587601290396 3036 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2190 6049624 200 µM -0.287052710264065 0.385150066391476 no 2108 0.387035980367454 2970 2265554 SGTC_319 1348-1596 45.5 µM -0.288413403879514 0.384636208322943 no 2109 0.386515154322035 3104 5380505 SGTC_3270 9137563 49.47 µM -0.289027920339354 0.384404206098141 no 2110 0.386280005792186 3018 17015724 SGTC_3010 9080089 71.4286 µM -0.289049889818412 0.384395912589986 no 2111 0.386271599807649 3029 17027233 SGTC_2998 9066762 71.4286 µM -0.290218346513797 0.38395489494408 no 2112 0.385824600723036 3098 4945196 SGTC_2335 9018011 154.17 µM -0.293512840009625 0.382712245096905 no 2113 0.384565093277952 3019 6458208 SGTC_1950 st077106 7.18 µM -0.294196240291992 0.382454624045626 no 2114 0.384303976702592 3013 13831864 SGTC_3191 9110352 49.47 µM -0.29601368020935 0.381769758039175 no 2115 0.383609817020589 2935 17122424 SGTC_1560 lithocholic acid 53.1 µM -0.296749448676494 0.381492603423204 no 2116 0.383328900957484 2974 9903 A bile acid which acts as a detergent. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.297285949320907 0.381290548752227 no 2117 0.383124103912901 2857 6708630 An antioxidant. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.297820922003579 0.381089101750899 no 2118 0.382919922655186 3343 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2402 5553605 200 µM -0.297839855745668 0.381081972732853 no 2119 0.382912696872037 3131 6758546 SGTC_487 nimodipine 119 µM -0.299083776197391 0.380613694727053 no 2120 0.382438062385416 2997 4497 L-type voltage-gated calcium channels inhibitor SGTC_93 0109-0045 59.227 µM -0.299501207991089 0.380456590286883 no 2121 0.382278825231536 2903 88733 SGTC_2512 diallyl trisulfide 49.23 µM -0.299801858807321 0.380343449694112 no 2122 0.382164148693215 2965 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_142 0335-0849 62.6745 µM -0.299940987131902 0.38029109653604 no 2123 0.382111084799112 3003 3889043 YPR107C YTH1 SGTC_669 0108-0021 26.2 µM -0.301574091013314 0.379676733475233 no 2124 0.381488380651927 3157 17201 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.302047024838909 0.379498875470491 no 2125 0.38130810769548 2986 1377 SGTC_1396 3511-0007 98.6 µM -0.304301699105765 0.378651302744889 no 2126 0.380449025401226 3048 X1396 SGTC_1373 2887-0003 58.5 µM -0.305021527618809 0.378380828875931 no 2127 0.38017487822404 3011 776948 SGTC_108 0509-0257 621.132 µM -0.305059570032311 0.378366536185006 no 2128 0.380160391418381 3030 536624 SGTC_1301 naphtanilide LB 4.81 µM -0.305503782388155 0.378199656100876 no 2129 0.379991244828373 3061 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2121 5257820 149.641 µM -0.306209738750654 0.377934491734696 no 2130 0.379722478940578 3100 791256 SGTC_829 1635-0120 117 µM -0.30820896874644 0.377183873046796 no 2131 0.378961664185076 3082 285054 SGTC_2804 7954240 19.48 µM -0.308256846292586 0.377165902911284 no 2132 0.378943449933645 3101 828705 SGTC_2674 ligustilide 100 µM -0.309114333083756 0.376844102887772 no 2133 0.378617278270292 3048 5319022 A signalling regulator. SGTC_321 4534-3890 65.3 µM -0.310015663213656 0.376505941426778 no 2134 0.378274522625808 3057 699746 SGTC_1097 itavastatin 7.23 µM -0.310799683175633 0.376211869494763 no 2135 0.377976455277026 2990 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2012 4023501 200 µM -0.312691353623571 0.375502633704128 no 2136 0.377257582605732 3035 3477460 SGTC_1914 st062367 72.6 µM -0.314204955872567 0.374935448113347 no 2137 0.376682689458853 2950 978205 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.315048074573708 0.374619627075585 no 2138 0.376362576389806 3127 5393153 SGTC_2137 5261020 140 µM -0.315784035469148 0.374344014649976 no 2139 0.376083218201154 2947 763655 SGTC_1727 st034309 9.9045 µM -0.315794695168644 0.374340023135264 no 2140 0.376079172437859 3208 870305 SGTC_2203 7227154 166.4 µM -0.316153310242221 0.374205747900276 no 2141 0.375943072252501 2981 896304 SGTC_1480 1070-0044 41.2 µM -0.316643582607205 0.37402220128812 no 2142 0.37575703097839 3033 3124987 SGTC_640 3381-0960 37.1 µM -0.317137470658329 0.373837329921266 no 2143 0.37556964687687 3027 1745025 SGTC_3122 9126309 49.47 µM -0.317889056750709 0.37355605314149 no 2144 0.375284546912009 3037 17591206 SGTC_3046 9092212 49.47 µM -0.318095522596039 0.373478796269227 no 2145 0.375206239918343 2990 25236637 SGTC_795 0685-0265 78 µM -0.318131644505644 0.373465280436311 no 2146 0.375192540369019 2961 302754 SGTC_2491 paeonol 100 µM -0.318926673913821 0.373167841567755 no 2147 0.374891058422384 2908 11092 Increases levels of cortical cytochrome oxidase. SGTC_2282 7944268 200 µM -0.31896908325635 0.373151977374533 no 2148 0.374874978583038 3168 2970414 SGTC_1298 1079-1278 263 µM -0.321187555988479 0.372322406912485 no 2149 0.374034130927295 2991 2840950 SGTC_1469 k284-2957 126 µM -0.321575825830992 0.372177278978419 no 2150 0.373887029999647 3000 23884841 SGTC_3197 9113331 49.47 µM -0.321647301360079 0.37215056475355 no 2151 0.373859952594864 3200 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1176 0848-0131 83.3 µM -0.322342216197041 0.371890870033618 no 2152 0.373596727263729 3052 6769040 SGTC_1391 3442-0225 151 µM -0.324155073248394 0.371213666765477 no 2153 0.372910316752109 2965 5227075 SGTC_735 3076-0345 636 µM -0.324563738511587 0.371061062460351 no 2154 0.372755637544798 3138 2888990 SGTC_3318 9139014 38.6185 µM -0.32479740270668 0.370973816386359 no 2155 0.372667205203965 2975 16643984 SGTC_1037 k284-1091 78.7 µM -0.325731775775389 0.37062500434953 no 2156 0.372313650332242 2944 3334711 SGTC_2090 5301565 104.445 µM -0.325830619388006 0.370588111124279 no 2157 0.372276255455755 2990 2056344 SGTC_1453 4237-0541 195 µM -0.326210405458942 0.370446367635212 no 2158 0.372132584608946 3110 739892 SGTC_2782 7736369 71.43 µM -0.326470505336447 0.370349303488141 no 2159 0.372034200615818 3028 2950836 YOL077C BRX1 SGTC_882 0843-0131 351 µM -0.326601753290793 0.370300327471949 no 2160 0.371984558635174 3065 5425421 SGTC_1905 st060207 84.5 µM -0.327786947833177 0.369858159831418 no 2161 0.371536378358889 2956 1948547 SGTC_850 0388-0143 75.9 µM -0.32790592898675 0.369813780309092 no 2162 0.371491395345875 2988 67273 SGTC_555 4296-0685 37 µM -0.330607572539641 0.368806545157824 no 2163 0.370470462766806 3031 2908540 YHR072W ERG7 SGTC_587 k089-0003 57 µM -0.330612926517559 0.368804549962902 no 2164 0.370468440438005 3010 9659696 SGTC_2597 laccaic acid a 100 µM -0.330654458048091 0.36878907308626 no 2165 0.370452753081683 3116 5491415 A textile dye. SGTC_1045 1348-1485 165 µM -0.331415264542724 0.36850559344212 no 2166 0.370165418176228 2978 6810614 SGTC_1161 k007-0610 110 µM -0.332073722323345 0.368260307106169 no 2167 0.369916795932534 3085 5843850 SGTC_348 k064-0012 10.7 µM -0.332286615810873 0.368181012266723 no 2168 0.369836422666021 2943 5066323 SGTC_1479 0549-0158 134 µM -0.333457549743464 0.36774498375327 no 2169 0.369394463962569 3028 5440202 SGTC_564 3555-0129 330 µM -0.333651964260405 0.367672604796588 no 2170 0.369321100601552 3006 563260 SGTC_3156 9099931 49.47 µM -0.335000629363067 0.367170637159747 no 2171 0.368812305729988 2961 18111053 SGTC_199 4063-0024 41.6 µM -0.335093744978856 0.367135988274384 no 2172 0.368777185579307 3106 306215 SGTC_1078 idebenone 36.1 µM -0.335143748244043 0.367117382202681 no 2173 0.368758326442899 3064 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2306 7482397 179.52 µM -0.335217375506253 0.367089986277447 no 2174 0.368730557899998 3165 891448 SGTC_684 1140-0066 328 µM -0.336515000546734 0.366607264911909 no 2175 0.368241270847275 3061 6813534 SGTC_1657 st012939 43.4 µM -0.33657015132347 0.366586753284223 no 2176 0.368220480228934 3131 24207257 SGTC_885 0865-0106 16.8 µM -0.336854966467645 0.366480831155911 no 2177 0.368113117387097 2998 2793380 SGTC_992 3909-8734 162 µM -0.33736434449292 0.366291419946189 no 2178 0.367921129857391 3033 4288319 SGTC_1645 Cervolide 78 µM -0.338039189943905 0.366040530167178 no 2179 0.367666827507924 3046 23173 A fragrance. SGTC_19 0279-0214 38.434 µM -0.339996018584273 0.365313356897626 no 2180 0.366929763115965 3012 3566274 YBR002C RER2 SGTC_2993 9054257 71.4286 µM -0.340049574343646 0.365293461938446 no 2181 0.366909597538638 2969 6470217 YGL055W OLE1 SGTC_3160 9100216 49.47 µM -0.342362667417642 0.364434537879545 no 2182 0.366038989935506 2998 17191039 SGTC_1682 st012968 530 nM -0.342962948919055 0.3642117455179 no 2183 0.36581316698945 3006 24207270 SGTC_700 3453-2283 142 µM -0.343443771374073 0.364033323047052 no 2184 0.365632317475525 3183 565664 SGTC_7 0192-1582 4.227 µM -0.343531187850013 0.36400088791069 no 2185 0.365599441129973 3045 252616 SGTC_2682 pyrogallin 40.03 µM -0.343906438267949 0.363861665520234 no 2186 0.365458324920067 3048 822798 An ATP competetive kinase inhibitor. SGTC_2580 diallyl disulphide 81.36 µM -0.344597990225754 0.363605138564263 no 2187 0.365198308458734 2985 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2466 5983409 37.09 µM -0.345132338850095 0.363406967084823 no 2188 0.364997441268218 3041 2879657 SGTC_890 0929-0006 47.2 µM -0.345234481994647 0.363369089874135 no 2189 0.364959048816116 3019 1378169 SGTC_749 1000-0129 128 µM -0.345655803600976 0.363212867498563 no 2190 0.364800701354996 3186 708470 SGTC_2873 9040596 71.43 µM -0.346226673422134 0.363001230253286 no 2191 0.364586185214138 3136 6463863 SGTC_1741 st038134 10.228 µM -0.348739666288237 0.362070092380674 no 2192 0.363642381081964 3246 1272587 SGTC_299 1273-0059 1.44 µM -0.349043653222872 0.361957511465199 no 2193 0.363528268731828 3112 2848077 SGTC_16 erodoxin 22.806 µM -0.349244923642492 0.36188297796403 no 2194 0.363452721354529 3135 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_80 0159-0065 512.242 µM -0.349636377644863 0.361738031590018 no 2195 0.363305803283009 3079 1548079 SGTC_2056 5235370 200 µM -0.350013437190274 0.36159843390397 no 2196 0.363164306660298 3029 5511916 SGTC_1439 4092-1168 46 µM -0.351514505637733 0.361042880374204 no 2197 0.362601196016361 3091 2886240 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.351529617035938 0.361037289051979 no 2198 0.362595528636564 3147 5024745 SGTC_1651 st011928 86.1 µM -0.352970632492227 0.36050423991071 no 2199 0.362055228584161 3127 720198 SGTC_2463 5473429 200 µM -0.353544444305986 0.360292055319379 no 2200 0.361840157735491 3074 5399405 SGTC_503 tyrphostin 8 294 µM -0.355035011612162 0.359741073333292 no 2201 0.361281681063248 3129 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_550 4123-0385 25.7 µM -0.355578978676222 0.359540070687487 no 2202 0.361077944332133 3028 5731123 SGTC_1137 ixabepilone 100 µM -0.3574837264366 0.358836549074036 no 2203 0.360364853432177 2992 154225 A novel microtubule stabilizer. SGTC_252 miconazole 1.30953 nM -0.357788322540555 0.35872409034523 no 2204 0.360250865070788 3111 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1125 tnp00248 1.32998 µM -0.359595590058862 0.358057088416651 no 2205 0.35957479095171 3202 24207736 SGTC_1636 st007707 68.9 µM -0.359820477001337 0.357974120429614 no 2206 0.359490694503908 3243 403051 SGTC_858 0438-0351 2.77 µM -0.35995235286694 0.357925470324082 no 2207 0.359441382703166 3073 2799119 SGTC_2143 5623677 140.463 µM -0.360713671282363 0.357644658750166 no 2208 0.359156751820173 3100 5375313 SGTC_2587 piperic acid 92.2 µM -0.361945456787921 0.357190479053657 no 2209 0.358696394987849 3084 5370536 SGTC_2681 menadione 3.18 µM -0.362284765167597 0.357065405944809 no 2210 0.358569620838179 3131 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2348 9022543 33.42 µM -0.363832443990526 0.356495108084812 no 2211 0.357991566913934 3167 3162678 YDL140C RPO21 SGTC_988 1497-1057 103 µM -0.364570934576321 0.356223097648722 no 2212 0.35771585725104 3150 3533044 SGTC_1726 st035556 14.5795 µM -0.365718847029009 0.355800428890993 no 2213 0.357287440543866 3228 5919439 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.366333916395141 0.355574029266639 no 2214 0.357057962157274 3058 689007 SGTC_2932 9016711 44.54 µM -0.366487218158733 0.355517608662456 no 2215 0.357000774310659 3181 7117328 SGTC_1167 k781-0610 148 µM -0.366919429057517 0.355358556438468 no 2216 0.356839559217286 3074 4525169 SGTC_814 3342-0569 96 µM -0.367115657623337 0.355286353268634 no 2217 0.356766374204343 3094 4346283 SGTC_1114 scopoletin 1.73284 µM -0.367977702239481 0.35496922170076 no 2218 0.356444930255051 3188 5280460 A coumarin with genotoxic properties. SGTC_1380 2291-0730 164 µM -0.368796136217279 0.354668226697037 no 2219 0.356139842421907 3137 2999191 SGTC_357 1325-0123 420 µM -0.370955838710431 0.353874390085816 no 2220 0.355335212109633 3178 1098503 SGTC_431 k089-0097 107 µM -0.371266015252032 0.353760431302727 no 2221 0.355219703920654 3147 5499420 SGTC_1934 st074720 32.6 µM -0.371361283313338 0.353725432470784 no 2222 0.355184229241829 3018 17250992 SGTC_1121 fusaric acid 630.51 nM -0.371755329161775 0.35358068413755 no 2223 0.355037512919414 3060 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2259 7964009 200 µM -0.372653096699635 0.353250978366372 no 2224 0.354703324615572 3207 313134 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.37413662618334 0.352706392515703 no 2225 0.354151335217027 3248 551469 SGTC_77 0828-0286 12.516 µM -0.3754834459613 0.352212252380806 no 2226 0.353650477785593 3155 745345 SGTC_3162 9099653 49.47 µM -0.375799709467085 0.352096253317187 no 2227 0.353532901905764 3192 25237511 SGTC_1689 st020265 53.493 µM -0.37802870178352 0.35127909479594 no 2228 0.352704636189491 3204 5758320 YPR016C TIF6 SGTC_2727 riluzole 51.77 µM -0.378338181160312 0.351165692509151 no 2229 0.352589692590831 3106 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_659 k018-0002 107 µM -0.378400743618746 0.351142769406161 no 2230 0.352566457930715 3203 6797879 YHR007C ERG11 SGTC_556 4058-0063 51.5 µM -0.378805273461902 0.350994561337085 no 2231 0.352416235532084 3120 6615692 SGTC_2233 sulbentine 40.3845 µM -0.379132504972657 0.350874689729123 no 2232 0.352294734755083 3127 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_105 0111-0055 734.78 µM -0.380042994543766 0.350541236870597 no 2233 0.351956750114488 3150 5179370 SGTC_2470 5664817 21.68 µM -0.384651293255273 0.348855288792424 no 2234 0.350247893008632 3108 2859561 SGTC_95 0471-0001 561.058 µM -0.384991023673749 0.348731115811094 no 2235 0.350122033003739 3092 4015405 SGTC_1311 1190-0148 100 µM -0.385249961374395 0.348636483808059 no 2236 0.350026115348807 3213 1961333 SGTC_442 cape 100 µM -0.385670830677732 0.348482691982466 no 2237 0.349870234185362 3214 5281787 SGTC_1764 st044502 93.5 µM -0.386430599112165 0.348205124504911 no 2238 0.349588895968467 3211 8407 SGTC_1418 3966-3099 2.4 µM -0.386650391211371 0.348124842641214 no 2239 0.349507523516824 3170 740335 SGTC_2347 9049783 174.81 µM -0.387696780836979 0.34774272888623 no 2240 0.34912021917326 3235 6467988 YPL169C MEX67 SGTC_657 3534-0529 86.7 µM -0.389188162155471 0.347198383246023 no 2241 0.348568479879859 3227 1049549 SGTC_53 0973-0023 39.979 µM -0.389632589665486 0.347036230636283 no 2242 0.34840412496591 3263 674768 SGTC_1105 epirubicin 18.1 µM -0.391217865223582 0.34645805960202 no 2243 0.347818102003494 3071 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_141 0443-0274 32.331 µM -0.392122707802733 0.346128211693548 no 2244 0.347483774984042 3254 1627241 SGTC_287 k060-0039 29.6 µM -0.392201305726224 0.34609956540763 no 2245 0.347454739716095 3226 5861974 SGTC_3056 9094900 49.47 µM -0.392524328312763 0.345981843843872 no 2246 0.347335419661026 3113 25236784 SGTC_2905 7799065 20.05 µM -0.394301278345846 0.345334522930356 no 2247 0.346679309798851 3258 1296806 SGTC_2618 avocadyne 43.43 µM -0.396216895941959 0.344637193590915 no 2248 0.345972513984175 3082 3015189 SGTC_2529 gangaleoidin 93.61 µM -0.396407626334781 0.344567792135651 no 2249 0.345902170466436 3062 4565183 SGTC_1093 fluphenazine 7.97 µM -0.397413734829677 0.344201784029129 no 2250 0.34553119438881 3120 6602611 An atypical antipsychotic. SGTC_655 k060-0012 42 µM -0.397620333767194 0.344126644287344 no 2251 0.345455034800644 3103 5994525 SGTC_1202 1988-0068 29.6 µM -0.39777998203097 0.344068584654105 no 2252 0.345396187156461 3107 2850480 SGTC_1711 st032263 62.8 µM -0.400926197767812 0.342925145053316 no 2253 0.344237230632268 3139 3958979 SGTC_231 b-estradiol 524 µM -0.403269014700165 0.342074620163694 no 2254 0.343375166787142 3102 450 A steroid. SGTC_1746 st038117 42 µM -0.40387132537943 0.341856089425154 no 2255 0.343153671701223 3186 2898218 SGTC_1659 st012954 42.1 µM -0.40390059979215 0.341845469413813 no 2256 0.343142907635057 3217 24207262 SGTC_1900 st060200 72.8 µM -0.404011049139206 0.341805402330653 no 2257 0.343102297066968 3099 688945 SGTC_328 k915-0120 63.5 µM -0.404175957610047 0.341745582736574 no 2258 0.343041666068758 3218 6624543 SGTC_2598 perillyl alcohol 100 µM -0.404285168588695 0.341705969272735 no 2259 0.343001515287943 3252 10819 An apoptosis inducer. SGTC_2322 7413319 38.22 µM -0.404397617934993 0.341665182996045 no 2260 0.342960175792451 3214 1840400 SGTC_2140 5586273 200 µM -0.40461433608629 0.341586582804831 no 2261 0.342880509498102 3191 854421 SGTC_1218 1348-1416 30.7 µM -0.404887132023042 0.34148765386697 no 2262 0.342780238759153 3101 6787668 SGTC_298 1391-0729 10 µM -0.405233165391304 0.341362181178811 no 2263 0.342653064303416 3106 3237558 SGTC_790 1575-0012 79.1 µM -0.407439874777994 0.340562434993487 no 2264 0.341842472718188 3258 378741 YLR208W SEC13 SGTC_3082 9117008 49.47 µM -0.407688345628639 0.340472430053112 no 2265 0.341751247374471 3143 41448529 SGTC_2314 7727897 200 µM -0.407844487367566 0.340415874634357 no 2266 0.341693925120869 3097 900724 SGTC_1271 0832-2808 169 µM -0.410464627558067 0.339467381327938 no 2267 0.340732573141237 3251 3663794 SGTC_2419 paclitaxel 166.5 µM -0.411085863129627 0.339242642224496 no 2268 0.340504787810263 3128 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1068 loratadine 26.9 µM -0.411219926341231 0.339194150816013 no 2269 0.340455639152764 3170 3957 A H1 histamine antagonist. SGTC_2368 9071271 200 µM -0.412544213167419 0.338715292120007 no 2270 0.339970290581924 3153 27209959 SGTC_3161 9100388 49.47 µM -0.412644067670817 0.338679195545112 no 2271 0.339933704837623 3144 25236368 SGTC_2430 5571206 200 µM -0.412729549140651 0.338648295879788 no 2272 0.33990238643428 3277 1731771 SGTC_2342 7990637 118.86 µM -0.413431659299253 0.338394539658843 no 2273 0.33964519158404 3232 2033102 YER133W GLC7 SGTC_1371 2421-0008 32.7 µM -0.415055401025062 0.337807969132845 no 2274 0.339050673581854 3128 2827552 SGTC_3107 9121808 49.47 µM -0.415444591926949 0.33766743383609 no 2275 0.338908234394192 3220 662681 SGTC_1018 4259-0013 28.1 µM -0.416590946055464 0.337253621463716 no 2276 0.33848881645473 3243 6801262 SGTC_774 k060-0086 136 µM -0.41737493330339 0.336970730036618 no 2277 0.338202093391202 3316 5911235 SGTC_266 formosanin C 406 nM -0.417693774530695 0.336855706758062 no 2278 0.33808551228122 3218 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1920 st075728 45.7 µM -0.417986516238591 0.336750112421846 no 2279 0.337978487870339 3292 3400306 SGTC_407 eburnamonine 100 µM -0.418194311697093 0.336675166703219 no 2280 0.337902527186276 3098 3195 SGTC_1092 toremifene 6.32 µM -0.418218228972443 0.33666654086068 no 2281 0.33789378452847 3138 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1749 st037932 54.2 µM -0.418265972636944 0.33664932221099 no 2282 0.33787633269668 3241 594497 SGTC_721 1187-1332 279 µM -0.419579970773704 0.336175566135884 no 2283 0.337396161374984 3092 25730 SGTC_2806 7952793 58.44 µM -0.420464926315425 0.335856645932734 no 2284 0.33707292320506 3271 2972490 SGTC_2785 7756463 72.73 µM -0.420926338400747 0.335690409135087 no 2285 0.336904435868998 3111 2201551 SGTC_998 3996-0085 177 µM -0.421409459198137 0.335516385612006 no 2286 0.336728056535476 3171 715391 SGTC_325 2810-4341 181 µM -0.422132437761465 0.335256029535646 no 2287 0.33646417621878 3259 774970 SGTC_1563 conessine 56.1 µM -0.422614924856037 0.335082322269469 no 2288 0.336288117799284 3232 441082 An anti-amoebic, histamine inhibitor. SGTC_835 0312-0010 67.2 µM -0.422946253654868 0.334963056143924 no 2289 0.336167237477257 3115 1626196 SGTC_3006 9075424 71.4286 µM -0.423030359969884 0.33493278362597 no 2290 0.336136555250123 3155 7465181 SGTC_1654 st012436 41.8 µM -0.423442594095702 0.334784423063822 no 2291 0.335986186838894 3239 4323132 SGTC_2225 6654152 15.4 µM -0.424535767101972 0.334391121629932 no 2292 0.335587563174548 3200 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3276 9139060 49.47 µM -0.426550570648389 0.333666712576825 no 2293 0.334853353382469 3184 4870619 SGTC_1450 4112-4260 37.6 µM -0.428185896609922 0.33307919753479 no 2294 0.334257891724481 3286 1633175 SGTC_1423 4048-0112 5.59 µM -0.430387966277284 0.332288718472776 no 2295 0.333456723757065 3244 X1423 SGTC_541 4513-1321 94 µM -0.430480398280103 0.332255554347158 no 2296 0.333423111259694 3176 747515 SGTC_1464 k208-0027 110 µM -0.432442397926261 0.331551909206066 no 2297 0.332709954449048 3347 X1464 SGTC_3254 9136651 49.47 µM -0.434101685567765 0.330957291194221 no 2298 0.332107300770991 3198 16454030 SGTC_2397 5161689 200 µM -0.434552709632456 0.330795736981414 no 2299 0.331943563669936 3352 2259942 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.434891854173125 0.330674278120602 no 2300 0.331820463782118 3271 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2655 perillic acid 100 µM -0.435106952281988 0.330597253621956 no 2301 0.331742398652829 3182 5702197 An apoptosis inducer. SGTC_2114 5491910 81.25 µM -0.436317926201857 0.330163749840072 no 2302 0.331303038724379 3273 2849228 SGTC_954 1189-0853 2.85 µM -0.436402264901853 0.330133566800589 no 2303 0.331272447987878 3236 2828194 SGTC_2658 polymyxin b sulfate 77.05 µM -0.436568711654309 0.33007400226719 no 2304 0.33121207890335 3192 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_524 r073-0010 27.8 µM -0.438478855892233 0.329390747871702 no 2305 0.330519597177802 3121 2772106 SGTC_2844 9010103 25.97 µM -0.438527200918616 0.329373462339172 no 2306 0.330502078241621 3310 2480525 SGTC_2172 5754775 163.918 µM -0.440176914007193 0.32878383406376 no 2307 0.329904489421217 3149 2263357 SGTC_1044 1222-0021 1.78 µM -0.440588499909809 0.32863679439782 no 2308 0.329755464917042 3229 4306703 SGTC_3223 9129970 49.47 µM -0.440962316715979 0.328503270784117 no 2309 0.329620139031543 3150 17248386 SGTC_2882 9058044 58.44 µM -0.441095090205141 0.328455850694702 no 2310 0.329572078903484 3250 18076804 SGTC_1775 st081588 35.1725 µM -0.442154746077735 0.328077493376163 no 2311 0.329188615330394 3278 1426443 YGL099W LSG1 SGTC_2024 5144227 134 µM -0.442770519909607 0.327857708134502 no 2312 0.328965864319774 3295 3475211 SGTC_446 go6976 132 µM -0.442984986239125 0.327781173674241 no 2313 0.328888297181064 3276 3501 A protein kinase C inhibitor. SGTC_1461 k072-0203 53.8 µM -0.443291366011166 0.327671851528888 no 2314 0.328777500019135 3212 5418714 SGTC_1327 1436-0082 2.18 µM -0.446333106590982 0.326587303010915 no 2315 0.327678322593157 3199 15992205 SGTC_2570 licareol 100 µM -0.447599104835137 0.326136335632936 no 2316 0.327221274656639 3224 443158 SGTC_1261 0712-0010 12.7 µM -0.448543190154348 0.325800203793984 no 2317 0.326880611525736 3353 2840123 SGTC_1232 0279-0259 161 µM -0.450193768549731 0.325212872587044 no 2318 0.326285364547311 3215 1560000 SGTC_654 1124-0271 80.9 µM -0.450697932535453 0.325033560565658 no 2319 0.326103636320847 3211 5403748 SGTC_996 3970-0799 1.8 µM -0.451465122581059 0.324760777894303 no 2320 0.32582717837259 3235 6615648 YGL040C HEM2 SGTC_2624 nerol 100 µM -0.451819304450753 0.324634876411128 no 2321 0.325699580760651 3213 637566 A natural product oil. SGTC_1416 3966-0321 25.3 µM -0.452165724689359 0.324511753346156 no 2322 0.325574799106053 3226 582530 YLR208W SEC13 SGTC_2726 cimetidine 79.27 µM -0.452269785374991 0.324474772327932 no 2323 0.325537319937922 3229 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1837 st055472 66.5 µM -0.452331370774783 0.324452886964193 no 2324 0.325515139773692 3367 676091 SGTC_2038 4100038 30.985 µM -0.453126321993716 0.324170442690074 no 2325 0.325228891222183 3286 3596803 SGTC_1700 st030840 7.9285 µM -0.453161620097417 0.324157903702459 no 2326 0.325216183358614 3286 5499307 SGTC_3007 9078383 71.4286 µM -0.455550478223031 0.323309770908823 no 2327 0.324356630495483 3200 6496995 SGTC_980 1473-0395 201 µM -0.456320420050769 0.323036608429019 no 2328 0.324079791015397 3159 768876 SGTC_2242 6630449 61.2675 µM -0.456636481106456 0.322924502868855 no 2329 0.323966176578372 3308 691249 YDR170C SEC7 SGTC_2316 5844804 197.44 µM -0.457772820467826 0.322521580905806 no 2330 0.323557832288554 3287 776813 SGTC_372 0155-0182 15.9 µM -0.459411638260771 0.321940857688824 no 2331 0.322969296131049 3199 771486 SGTC_1640 st009078 66.4 µM -0.459994101572528 0.321734563524902 no 2332 0.322760227141572 3298 690618 SGTC_247 mechlorethamine 29.705 µM -0.460814329093904 0.321444152306983 no 2333 0.322465910208363 3211 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3061 glucosamine 200 µM -0.462096620041716 0.320990360754247 no 2334 0.322006016959219 3321 91431 and experimental redox chemotherapeutic SGTC_3055 9094636 49.47 µM -0.462272112414266 0.320928276313986 no 2335 0.321943097854306 3391 25236176 SGTC_210 3551-0445 56.827 µM -0.463043838943951 0.320655319841749 no 2336 0.321666472107749 3346 2865180 YOR207C RET1 SGTC_678 1218-2179 85.9 µM -0.463491365836661 0.320497075837048 no 2337 0.321506101143865 3276 6820081 YOR116C RPO31 SGTC_2045 5106652 78.05 µM -0.463887779144871 0.320356932671428 no 2338 0.321364074478191 3307 673349 SGTC_1066 ketoconazole 628 nM -0.464187191874805 0.320251098895808 no 2339 0.321256818418255 3338 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1778 st046819 58.9 µM -0.467134142480955 0.319210217976287 no 2340 0.320201954049945 3222 671715 SGTC_1036 k216-0215 33.5 µM -0.467202668906374 0.319186030930094 no 2341 0.320177442173562 3258 622330 SGTC_3045 9092950 49.47 µM -0.469988818108313 0.318203286109322 no 2342 0.319181503247947 3373 44120432 SGTC_638 3970-0837 4.09 µM -0.470373624465274 0.318067655556593 no 2343 0.319044052382589 3239 4118451 YLR208W SEC13 SGTC_713 1488-1073 324 µM -0.470602742679381 0.317986911121718 no 2344 0.318962224341226 3301 3312542 SGTC_1646 st011709 75.6 µM -0.47094156389498 0.317867521685942 no 2345 0.318841232776088 3329 5757843 SGTC_591 4299-0174 154 µM -0.471711817788431 0.317596180034469 no 2346 0.318566250343241 3249 5509088 SGTC_1454 4239-0054 42.6 µM -0.473393885876894 0.317003969175834 no 2347 0.317966095558381 3400 1340767 SGTC_2502 avocadyne acetate 18.59 µM -0.474257221604266 0.316700193743954 no 2348 0.317658246450312 3162 3952079 SGTC_2132 5317594 122.667 µM -0.474351708114696 0.316666954986509 no 2349 0.317624562004529 3186 794577 SGTC_186 3455-3465 67.277 µM -0.475009808291868 0.316435487538187 no 2350 0.317389991147036 3224 755278 SGTC_1516 st013856 110 µM -0.475374190556958 0.316307357671045 no 2351 0.317260143574995 3306 5281404 A mutagen and neurotoxin. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.475613580258556 0.316223191671134 no 2352 0.317174849326787 3407 94937 An inhibitor of serotonin biosynthesis. SGTC_2228 7354201 200 µM -0.475886142497579 0.316127374272319 no 2353 0.317077747568105 3263 753451 SGTC_1335 1486-0900 202 µM -0.475953637802824 0.316103648664672 no 2354 0.317053703949101 3279 X1335 SGTC_40 0327-0103 19.753 µM -0.475982879031231 0.316093370171349 no 2355 0.317043287687292 3209 409036 SGTC_502 l-744,832 89.3 µM -0.476875193917993 0.315779783718629 no 2356 0.316725498506291 3333 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2721 ifenprodil 61.44 µM -0.476903874663963 0.315769706634251 no 2357 0.316715286381919 3365 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_601 0986-0029 62.9 µM -0.476974353200445 0.31574494432594 no 2358 0.316690192245154 3282 24747981 SGTC_2031 5180455 200 µM -0.47857640715256 0.315182293311416 no 2359 0.316120002875937 3257 29949 SGTC_1720 st037298 9.481 µM -0.479528249782558 0.314848203249237 no 2360 0.31578143804862 3314 597396 SGTC_26 0302-0163 425.158 µM -0.47966953311287 0.314798626698299 no 2361 0.315731197561055 3286 3100915 SGTC_2267 7931562 200 µM -0.480115775932146 0.314642061288062 no 2362 0.315572535550137 3172 934880 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.481761625284603 0.314064899173655 no 2363 0.314987646473425 3312 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2651 TUB2.036 5 µM -0.48211589133238 0.313940725482957 no 2364 0.314861810764633 3410 15992207 YFL037W TUB2 SGTC_1630 st005209 31.3 µM -0.482495445973329 0.31380771127 no 2365 0.314727016365107 3373 3367314 SGTC_1554 st069299 38.7 µM -0.483370235723752 0.313501235007631 no 2366 0.314416439025812 3319 24207999 SGTC_3345 9148410 3.559 µM -0.483904241305817 0.313314213262702 no 2367 0.314226915102553 3337 4903596 SGTC_425 3825-7017 13.1 µM -0.485578489669535 0.312728162086883 no 2368 0.313633025239044 3414 3397440 SGTC_964 1287-0107 19.4 µM -0.485918175398543 0.312609316728789 no 2369 0.313512590670532 3381 51516812 YPR165W RHO1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.485929966354013 0.312605191793934 no 2370 0.313508410579111 3209 279621 SGTC_2795 7780010 54.55 µM -0.486415785619254 0.312435253731855 no 2371 0.313336200331677 3355 953673 SGTC_1096 rimcazole 32.2 µM -0.486510783851589 0.312402028307455 no 2372 0.313302530693491 3230 18528119 A dopamine reuptake inhibitor. SGTC_2746 daunorubicin 9.88 µM -0.486738431761434 0.312322415154599 no 2373 0.31322185318018 3262 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.486904677240652 0.312264281228606 no 2374 0.313162942091282 3296 91467 include heat shock SGTC_857 0438-0306 1.35 µM -0.487106158463622 0.312193832076247 no 2375 0.313091551183604 3364 4686136 SGTC_35 0133-0054 64.071 µM -0.487335299713952 0.312113719770073 no 2376 0.313010368004423 3279 99677 SGTC_775 4577-0580 57.3 µM -0.487642957750763 0.312006170417785 no 2377 0.312901381121531 3445 2006902 SGTC_2922 7999257 32.47 µM -0.487825798191089 0.311942261683884 no 2378 0.312836618221066 3344 2988377 SGTC_1497 4476-2978 41.3 µM -0.488648193502281 0.311654877553001 no 2379 0.312545393572777 3342 1528379 SGTC_3169 9102970 49.47 µM -0.489584175359417 0.311327940397712 no 2380 0.312214088304511 3357 17027839 SGTC_1913 st060213 96.1 µM -0.48960929640901 0.311319167698934 no 2381 0.312205198410664 3408 688959 SGTC_1897 st060201 15 µM -0.490669351877205 0.310949075971716 no 2382 0.311830163293668 3281 611878 SGTC_978 1416-0512 87.4 µM -0.491804397163616 0.310553015310587 no 2383 0.31142881387278 3344 6814003 SGTC_620 0109-0052 432 µM -0.491929851925187 0.310509252815065 no 2384 0.311384467094626 3389 493037 SGTC_906 1165-0455 526 µM -0.492483685913163 0.310316090474194 no 2385 0.311188726030076 3310 3252859 SGTC_765 1319-0117 244 µM -0.493115587041254 0.31009576431438 no 2386 0.310965458965846 3301 3487746 YGL099W LSG1 SGTC_3227 9130768 49.47 µM -0.494748407987674 0.309526761323692 no 2387 0.310388863216259 3337 17720899 SGTC_2151 5563267 85.4165 µM -0.49587427193868 0.30913468761679 no 2388 0.309991559609264 3297 5310824 SGTC_907 3448-6986 75.5 µM -0.496515126079526 0.308911611962125 no 2389 0.309765509036873 3421 590582 SGTC_1164 k060-0068 93.7 µM -0.498768449654014 0.308127809863925 no 2390 0.308971258314524 3336 5963676 SGTC_291 SEC14.278 35.5 µM -0.499175984468097 0.307986145115225 no 2391 0.308827705762083 3379 1068044 SGTC_50 0929-0078 56.389 µM -0.500271595295161 0.307605437491409 no 2392 0.308441925932967 3234 1377751 SGTC_2957 9076800 11.52 µM -0.502600797292505 0.30679676477241 no 2393 0.307622484305996 3278 16459615 SGTC_1836 st055642 81 µM -0.503251141764855 0.30657114007871 no 2394 0.307393856274071 3275 8571 SGTC_3239 9133757 49.47 µM -0.503533112622491 0.306473338403831 no 2395 0.30729475291155 3351 17036923 SGTC_1245 0418-0076 17.2 µM -0.505718065065027 0.305715954623433 no 2396 0.306527292292135 3392 6790114 SGTC_2645 abamectin 100 µM -0.505795123461148 0.305689258528387 no 2397 0.306500241125697 3359 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_333 3486-0131 40.1 µM -0.506043497958512 0.305603218747561 no 2398 0.30641305702633 3427 6744690 SGTC_838 0109-0203 71.4 µM -0.506184123045007 0.305554509359576 no 2399 0.306363699845691 3336 759422 SGTC_3204 9114183 49.47 µM -0.507778123400287 0.305002623995147 no 2400 0.305804476722403 3255 17027248 SGTC_2414 st077232 92.9 µM -0.508415632111515 0.304782025510238 no 2401 0.305580946153739 3214 729801 SGTC_2571 chrysanthemic acid 100 µM -0.511351091294607 0.303767178867282 no 2402 0.304552617753328 3306 2743 An insecticide. SGTC_837 0091-0265 12.5 µM -0.512925009764177 0.303223665640959 no 2403 0.304001889043279 3284 759367 SGTC_1279 0874-0590 65.2 µM -0.514400114804402 0.302714670238678 no 2404 0.303486139500179 3340 3523074 SGTC_1159 4092-0538 61.2 µM -0.515501110108802 0.302335013673501 no 2405 0.30310144703055 3372 717301 SGTC_2174 5790901 200 µM -0.515731515122836 0.302255590073182 no 2406 0.303020970140334 3378 786020 SGTC_554 4483-2211 187 µM -0.516881882296556 0.30185918371684 no 2407 0.302619307884978 3352 747107 SGTC_2944 9067346 25.62 µM -0.520055193726549 0.300766901787315 no 2408 0.301512553222543 3400 6473075 SGTC_2293 7624732 200 µM -0.520845368914247 0.300495194048002 no 2409 0.301237247588342 3364 894453 SGTC_1558 st069300 45.6 µM -0.52101797965073 0.300435855292017 no 2410 0.301177123200774 3376 24208000 SGTC_3159 9100096 49.47 µM -0.522248856132689 0.300012867844233 no 2411 0.300748536740878 3340 25236875 SGTC_191 3914-0123 66.505 µM -0.522428731381421 0.299951076762286 no 2412 0.300685927924425 3273 3144412 SGTC_776 4476-4378 112 µM -0.523643181969785 0.299534037224787 no 2413 0.300263370573667 3401 2892008 SGTC_743 1275-0778 158 µM -0.523843620554131 0.299465232350333 no 2414 0.30019365555449 3382 2849257 YMR203W TOM40 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.524581003929842 0.299212171265255 no 2415 0.299937247505391 3490 16725076 SGTC_1976 st070609 63.5 µM -0.525519127540391 0.298890358888473 no 2416 0.299611180018234 3366 682556 SGTC_3327 9140648 26.9345 µM -0.527199897076285 0.298314184071955 no 2417 0.299027390071311 3416 8029710 SGTC_2218 6965428 192.983 µM -0.527321229767215 0.298272610294358 no 2418 0.298985266987482 3402 675684 SGTC_1500 4488-1866 171 µM -0.52747302623009 0.298220602038554 no 2419 0.298932571587532 3479 2900003 SGTC_2697 mebhydrolin 72.4 µM -0.527785625426662 0.298113512824688 no 2420 0.29882406759618 3451 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.529014831291888 0.297692585480375 no 2421 0.298397580708446 3421 756377 SGTC_448 monastrol 171 µM -0.52903887326246 0.297684355289899 no 2422 0.298389241837421 3365 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2610 ononetin 44.17 µM -0.533059631160546 0.296309408723836 no 2423 0.296996151218507 3383 259632 SGTC_2398 5228213 48.84 µM -0.533871196739172 0.29603223770578 no 2424 0.296715325581315 3475 80771 YMR134W ERG29 SGTC_73 0327-0325 16.231 µM -0.534144035103508 0.295939082955638 no 2425 0.296620942772603 3402 53298 SGTC_1171 0368-0077 21.4 µM -0.534858846178513 0.295695090043863 no 2426 0.296373733846545 3333 3239779 SGTC_2015 5119600 184 µM -0.535032179917382 0.295635938404938 no 2427 0.296313802662137 3447 2828786 SGTC_3282 9108498 15.4605 µM -0.535214587641853 0.295573696064134 no 2428 0.296250740094309 3384 16459645 SGTC_1063 disulfiram 1.84 µM -0.535979352159248 0.295312803786679 no 2429 0.295986410349168 3391 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_703 3875-0075 71.8 µM -0.536537671972025 0.295122405142261 no 2430 0.295793503620482 3397 2850814 SGTC_2575 plumbagin 510 nM -0.538401603102742 0.294487175693117 no 2431 0.295149909933768 3330 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1129 3453-1384 223 µM -0.538675052277033 0.294394037067649 no 2432 0.295055545384087 3478 1084452 SGTC_2457 5731572 11.68 µM -0.540429337462089 0.293796839508763 no 2433 0.294450490094641 3435 2865357 SGTC_2725 haloperidol 53.21 µM -0.540723102088946 0.293696890331744 no 2434 0.294349226294202 3372 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_701 4424-0219 185 µM -0.541082947880379 0.293574479441623 no 2435 0.294225205530065 3477 2911779 SGTC_2386 9075165 157.42 µM -0.541806590784222 0.293328385064741 no 2436 0.293975875291707 3411 16452277 SGTC_378 3970-0959 8.33 µM -0.541877640289499 0.293304227910274 no 2437 0.293951400543048 3430 6615653 SGTC_557 1315-0110 16.2 µM -0.544261618362254 0.292494199606324 no 2438 0.293130727474272 3406 6833801 SGTC_3090 9117696 49.47 µM -0.545262246386685 0.292154516193791 no 2439 0.292786582927829 3352 7923821 SGTC_1986 st071812 45 µM -0.545416575070963 0.292102142545549 no 2440 0.29273352158951 3432 11838594 SGTC_1308 1187-1617 41.4 µM -0.54587533556451 0.291946481412185 no 2441 0.29257581678184 3397 2882570 SGTC_2093 5331342 194.4 µM -0.546367994764638 0.291779361202754 no 2442 0.29240650283241 3462 33839 SGTC_417 st075190 100 µM -0.548721856708509 0.29098149838899 no 2443 0.291598172161535 3483 222757 SGTC_2204 7233102 200 µM -0.548981123205025 0.29089368002365 no 2444 0.291509202185704 3361 2172480 SGTC_806 3966-4455 5.86 µM -0.549953768070113 0.290564337644707 no 2445 0.291175541946179 3351 714982 SGTC_538 2922-0838 53.3 µM -0.551126858344051 0.290167355726195 no 2446 0.290773357455985 3491 777039 SGTC_543 3844-1095 191 µM -0.552415320752954 0.289731624153448 no 2447 0.290331918119937 3423 4230703 SGTC_2656 pseudo-anisatin 100 µM -0.552703319629096 0.289634270839825 no 2448 0.290233289928192 3417 6708809 A neurotoxin. SGTC_2266 7929956 200 µM -0.552945975986089 0.289552256745224 no 2449 0.290150201935995 3454 2967153 SGTC_507 nimesulide 162 µM -0.554254453827597 0.289110199525278 no 2450 0.28970235809345 3515 4495 A COX2 inhibitor. SGTC_2818 7996756 12.99 µM -0.554348714258097 0.289078366763528 no 2451 0.289670108745251 3375 2241621 SGTC_3339 9145883 14.936 µM -0.555181660270208 0.288797143601293 no 2452 0.289385205945395 3431 2030670 SGTC_1997 st073024 93.8 µM -0.556308141768568 0.288417020606056 no 2453 0.289000111133558 3464 686268 SGTC_2768 sulfasalazine 50.2 µM -0.557155274797284 0.288131317181065 no 2454 0.288710672271626 3514 5384001 An antioxidant and salicylic acid derivative. SGTC_3051 9093778 49.47 µM -0.557823442719869 0.287906065632109 no 2455 0.288482476528191 3423 17217378 SGTC_155 k072-0202 43.6 µM -0.557931377588379 0.287869686629013 no 2456 0.28844562209777 3433 5857737 SGTC_1520 flindersine 88 µM -0.559768344319704 0.287250877682566 no 2457 0.28781872916728 3541 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_438 sphingosine 6.67 µM -0.563034592674104 0.286152151898713 no 2458 0.286705664255558 3297 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3121 9125696 49.47 µM -0.563857469057464 0.285875661550729 no 2459 0.286425568446567 3478 1235365 SGTC_2849 9019321 12.99 µM -0.564091112067129 0.285797179556345 no 2460 0.286346063255517 3445 16489627 SGTC_1485 3909-9022 254 µM -0.564276967979017 0.285734756833956 no 2461 0.286282826775092 3482 714516 SGTC_3025 9087895 49.47 µM -0.564919434749354 0.285519023923024 no 2462 0.286064281984084 3485 17173641 SGTC_1049 3226-0134 66 µM -0.5652506164707 0.285407847225661 no 2463 0.285951656484423 3475 5702385 SGTC_810 3825-7150 143 µM -0.568500255603291 0.284318048291935 no 2464 0.284847666095376 3514 22330411 YGL099W LSG1 SGTC_2329 6138490 200 µM -0.569469661210011 0.283993334016709 no 2465 0.284518727002377 3461 720019 SGTC_571 k831-0106 44.2 µM -0.570917014840779 0.283508855688977 no 2466 0.284027948322569 3471 4783639 SGTC_261 5-fluorouridine 15.376 µM -0.571168972329965 0.283424557470367 no 2467 0.283942554241137 3543 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_62 0180-0423 3.232 µM -0.573542812580411 0.282630924652854 no 2468 0.283138609966435 3442 30102 YGL099W LSG1 SGTC_258 haloperidol 50.781 µM -0.573813985220324 0.282540333031826 no 2469 0.283046841964161 3430 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.576645271390357 0.2815953098287 no 2470 0.282089555152647 3542 165506 SGTC_1135 dihydrocapsaicin 536.708 nM -0.576728227084495 0.281567643982083 no 2471 0.282061530507049 3454 107982 A Capsaicinoid. SGTC_97 0535-0701 19.132 µM -0.576988024953728 0.281481009491605 no 2472 0.281973772534035 3469 2832013 YGL099W LSG1 SGTC_2010 4012422 159 µM -0.577348789057994 0.281360727242297 no 2473 0.281851930662129 3415 952393 SGTC_374 0880-0231 82.3 µM -0.579423819420135 0.280669374122486 no 2474 0.281151617889105 3467 6833587 SGTC_623 k072-0108 16.9 µM -0.580207054498481 0.280408631734102 no 2475 0.280887498466805 3453 5382803 SGTC_2744 captopril 92.04 µM -0.580232773899533 0.280400071621992 no 2476 0.280878827506866 3457 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1318 1280-3875 124 µM -0.581298155928895 0.280045594889343 no 2477 0.280519761620306 3475 373245 SGTC_913 3487-1245 167 µM -0.581485656171396 0.279983231797524 no 2478 0.280456591378651 3416 4016153 SGTC_2018 5133068 143 µM -0.582075330662834 0.279787148350294 no 2479 0.280257970502795 3472 785362 SGTC_836 0330-0104 1.35 µM -0.583760616608565 0.279227110676447 no 2480 0.279690689239577 3487 46494820 SGTC_1723 st034307 2.5525 µM -0.586440484571719 0.27833768685558 no 2481 0.278789772587184 3478 867466 SGTC_3053 9095903 49.47 µM -0.586673140682326 0.278260535601617 no 2482 0.278711625056341 3519 17174018 SGTC_1964 st076914 61 µM -0.587719602904881 0.277913646510634 no 2483 0.278360257765236 3514 24208661 SGTC_1274 0865-0114 173 µM -0.588125715283953 0.277779082228409 no 2484 0.278223956877361 3456 870624 SGTC_2356 9061756 188.97 µM -0.592653396265993 0.276281005275204 no 2485 0.276706568202317 3466 20104043 SGTC_2923 7992654 58.14 µM -0.594581468386904 0.275644268355376 no 2486 0.276061635212215 3486 2985126 SGTC_428 3448-4153 16.5 µM -0.594952388062659 0.275521856644151 no 2487 0.275937648655591 3430 3834874 SGTC_1587 estradiol valerate 56.1 µM -0.595937523720403 0.27519686991578 no 2488 0.27560848223905 3539 13791 A steroid. SGTC_1943 st076331 65.2 µM -0.598490369693526 0.274355589944449 no 2489 0.274756391411089 3559 24208415 SGTC_2444 5485484 36.41 µM -0.600135412178626 0.273814146389736 no 2490 0.27420799691376 3550 6790631 SGTC_135 0933-0004 26.348 µM -0.600585993454218 0.273665935876638 no 2491 0.274057884648776 3503 21230617 YGL099W LSG1 SGTC_400 oxethazaine 37.5 µM -0.602269222178383 0.273112619728379 no 2492 0.27349747227452 3489 4621 A local anesthetic. SGTC_1571 st070080 73.4 µM -0.603652780761095 0.272658227615455 no 2493 0.273037256905442 3569 4315245 SGTC_483 fpl-64176 144 µM -0.605457748265273 0.272065999803878 no 2494 0.272437445240537 3538 3423 SGTC_1 0258-0098 57.368 µM -0.605663296004269 0.271998598131425 no 2495 0.272369180867475 3441 6790032 YDR047W HEM12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.609222459185957 0.270832822544617 no 2496 0.271188497772684 3550 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3021 9087658 49.47 µM -0.610269939474195 0.270490204310436 no 2497 0.270841503228162 3541 25237042 SGTC_1833 st055984 71 µM -0.61110495916404 0.270217234607842 no 2498 0.270565048473004 3483 676288 SGTC_719 2810-4230 27.3 µM -0.611172746287537 0.270195080900821 no 2499 0.270542611989181 3506 721079 SGTC_3323 9138564 53.9225 µM -0.612631229026499 0.269718650042707 no 2500 0.270060102134611 3560 43912313 YNL103W MET4 SGTC_1815 st051655 58.2 µM -0.613226445299425 0.269524336483185 no 2501 0.269863310514834 3518 5984156 SGTC_1548 st061468 90.8 µM -0.614007174589939 0.269269566982076 no 2502 0.269605293088407 3510 390799 SGTC_2761 levamisole 97.89 µM -0.614870003008825 0.268988147263238 no 2503 0.269320287180449 3577 26879 An alkaline phosphatase inhibitor. SGTC_352 k048-0007 5.11 µM -0.61535707915139 0.268829347955675 no 2504 0.269159464951401 3525 6811911 SGTC_2108 5365811 200 µM -0.615518140715737 0.268776848117567 no 2505 0.269106296435255 3542 780283 SGTC_1259 0671-0132 43 µM -0.615874521755809 0.268660699995516 no 2506 0.268988669156226 3459 X1259 SGTC_631 k072-0230 41.5 µM -0.616686324095804 0.268396219737885 no 2507 0.26872082171834 3548 5773147 SGTC_1344 1488-0097 29.1 µM -0.617815009124511 0.268028718732227 no 2508 0.268348644258202 3543 747966 SGTC_248 streptozotocin 5.23457 mM -0.617921142372245 0.267994174673096 no 2509 0.268313660764359 3576 5300 DNA alkylating agent. SGTC_1346 1488-2224 62.4 µM -0.619174344892109 0.267586454144178 no 2510 0.267900755434716 3554 3722427 SGTC_968 1309-0633 340 µM -0.622123653828691 0.266628153020853 no 2511 0.266930281235829 3547 3761976 SGTC_304 1310-0298 97 µM -0.622630588953493 0.266463612583463 no 2512 0.266763652557116 3518 1550234 SGTC_1832 st054113 55 µM -0.622834055155166 0.266397586198861 no 2513 0.266696788363644 3559 1251267 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.623664761182446 0.266128101467699 no 2514 0.266423885066013 3528 15053 SGTC_2251 lansoprazole 556 µM -0.625431157217427 0.265555533935053 no 2515 0.26584405914505 3436 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1866 st057638 64 µM -0.626777037946095 0.265119693935083 no 2516 0.265402698581861 3519 688802 SGTC_1874 staurosporine 7.6 µM -0.626884455756301 0.265084924212901 no 2517 0.265367488619196 3559 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_335 4077-0256 27.6 µM -0.62761107187126 0.264849789044986 no 2518 0.265129376923561 3568 3121989 SGTC_2423 st077119 87.2 µM -0.627742140884104 0.264807386006522 no 2519 0.265086437236468 3523 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1299 1079-1439 3.74 µM -0.628165504163015 0.264670444420878 no 2520 0.264947762788312 3491 323161 SGTC_384 k007-0144 5.16 µM -0.629258950396226 0.264316923731489 no 2521 0.264589770453952 3560 6824886 SGTC_514 4466-0038 2.65 nM -0.630041927658429 0.264063928156614 no 2522 0.264333576377108 3540 5722064 SGTC_1621 st003705 32.4 µM -0.63081384924903 0.263814625729545 no 2523 0.264081123458883 3595 24207032 SGTC_2208 7283366 200 µM -0.631103157382096 0.263721220717423 no 2524 0.263986538404816 3585 898663 SGTC_1989 st071868 50.2 µM -0.632535075966384 0.263259164964953 no 2525 0.2635186479448 3565 16414057 SGTC_1709 st033179 39.1045 µM -0.632627984348255 0.263229199302112 no 2526 0.263488304040916 3557 573381 SGTC_349 k015-0014 24 µM -0.633592561017472 0.26291819816615 no 2527 0.263173378429967 3535 2196908 SGTC_2917 7979103 53.79 µM -0.634111098913924 0.262751087600995 no 2528 0.263004159976792 3592 2980565 SGTC_3228 9131799 49.47 µM -0.635407095416323 0.262333661134622 no 2529 0.262581470823194 3534 17015818 SGTC_1486 3970-0793 4.53 µM -0.635660413038619 0.262252109965058 no 2530 0.262498891938528 3591 2844330 SGTC_34 0469-0683 81.75 µM -0.635714917234846 0.262234564992086 no 2531 0.262481125880997 3547 3690923 SGTC_1952 st077036 64.1 µM -0.635885668937043 0.262179603686004 no 2532 0.262425472049399 3586 2937007 SGTC_1875 nocodazole 6 µM -0.636635722582937 0.261938247451002 no 2533 0.262181075441429 3589 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3139 9095020 49.47 µM -0.636725496959136 0.261909367012588 no 2534 0.262151831279583 3408 25236292 SGTC_948 3448-0295 75.3 µM -0.637148249645517 0.261773389324363 no 2535 0.262014141316356 3603 678569 SGTC_3217 9129673 49.47 µM -0.638321684009121 0.261396146008893 no 2536 0.261632149734873 3584 17248312 SGTC_2295 7971645 200 µM -0.638484014266061 0.261343981013825 no 2537 0.261579328396211 3545 2978226 YKL099C UTP11 SGTC_2933 9026794 32.47 µM -0.639794955479438 0.260922904752191 no 2538 0.261152956302014 3551 17586027 SGTC_254 nsc-64875 3.808 µM -0.640408673370385 0.260725897630341 no 2539 0.260953472776772 3598 56993 SGTC_2703 st077852 53.4 µM -0.642634626304255 0.26001199622643 no 2540 0.260230604714153 3577 6281836 SGTC_387 norethindrone acetate 66.7 µM -0.644124305775927 0.259534794033196 no 2541 0.25974741512534 3567 541197 SGTC_1911 st060208 74.3 µM -0.644334861389914 0.259467381389892 no 2542 0.259679157073333 3582 688783 SGTC_1207 2099-0101 141 µM -0.644472005062794 0.259423477581537 no 2543 0.259634702730557 3580 5837381 SGTC_2486 5283202 22.39 µM -0.645130307310137 0.259212788693353 no 2544 0.259421372496641 3538 1377751 SGTC_1578 josamycin 24.2 µM -0.645437316535496 0.259114560988352 no 2545 0.259321913679271 3514 5282165 A P450 substrate. SGTC_812 4251-0442 148 µM -0.646123380452197 0.258895124183358 no 2546 0.259099727400736 3593 5723007 SGTC_2471 5466956 24.79 µM -0.646400695899195 0.25880645242913 no 2547 0.25900994492487 3539 724419 SGTC_1056 3448-1962 115 µM -0.646437809061775 0.258794586669147 no 2548 0.258997930545239 3575 715507 SGTC_465 cgp-37157 41 µM -0.646787399494859 0.258682830001931 no 2549 0.258884774272048 3509 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_330 1488-0319 80.1 µM -0.647652654364777 0.258406333798678 no 2550 0.258604816527941 3568 6846614 SGTC_2639 lactacystin 53 µM -0.647790468816323 0.25836230869213 no 2551 0.258560240417193 3614 3870 A proteasome inhibitor. SGTC_688 0527-0193 473 µM -0.648436268869694 0.258156058341979 no 2552 0.258351409288589 3579 4007154 SGTC_2253 7938677 135.83 µM -0.648965459112324 0.257987113539076 no 2553 0.258180351225572 3634 2301972 SGTC_1569 carminic acid 40.6 µM -0.651736086029165 0.257103523688068 no 2554 0.257285719533912 3611 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1448 4255-0083 152 µM -0.651978615599197 0.257026252755011 no 2555 0.257207483830894 3638 5399660 SGTC_1249 0481-0015 10.2 µM -0.653000970645849 0.256700659007203 no 2556 0.256877826378951 3562 4227577 SGTC_1347 1493-0251 600 nM -0.65352621339582 0.25653346626329 no 2557 0.256708547870669 3607 3986378 SGTC_2464 5717415 7.67 µM -0.654450059349126 0.256239529753311 no 2558 0.256410946012815 3507 5285744 SGTC_1716 st033144 30.6155 µM -0.656154679907488 0.255697638428016 no 2559 0.255862302649798 3619 674617 SGTC_862 0452-0056 10.2 µM -0.659476163105773 0.254643475076332 no 2560 0.254795024020832 3564 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_953 1188-0045 9.7 µM -0.659937631863677 0.25449719566352 no 2561 0.254646926760654 3593 6144426 SGTC_2033 5192550 145 µM -0.660625484931296 0.254279237208596 no 2562 0.25442626063002 3582 182073 SGTC_2250 alverine citrate 130 µM -0.662008932092765 0.253841163946794 no 2563 0.253982748654645 3561 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_756 0508-1999 28.3 µM -0.662823045829197 0.25358355734013 no 2564 0.253721945986225 3585 6753853 SGTC_3222 9128301 49.47 µM -0.663872122373704 0.253251805048592 no 2565 0.253386080074788 3631 4911358 SGTC_1540 guanosine 70.6 µM -0.663964616261038 0.253222566409426 no 2566 0.253356479013189 3569 6802 Guanosine is a purine nucleoside SGTC_82 0054-0107 293.755 µM -0.665000555541793 0.252895212518017 no 2567 0.253025068873805 3634 3104697 SGTC_64 000l-0018 272.079 µM -0.665908568537082 0.252608466256475 no 2568 0.252734771666464 3581 6811119 SGTC_1457 k015-0032 57.3 µM -0.666862524480173 0.252307396011132 no 2569 0.25242997524396 3627 4302660 SGTC_1633 st005664 67.9 µM -0.667724772165745 0.252035431920488 no 2570 0.252154647107259 3630 2063822 SGTC_2326 6164455 177.58 µM -0.668008788216594 0.251945883454854 no 2571 0.252063991372257 3608 2888790 SGTC_162 k030-0015 37.8 µM -0.669235268206202 0.251559374965221 no 2572 0.251672705950592 3673 1809920 YMR134W ERG29 SGTC_409 arachidonic acid 100 µM -0.669711240360732 0.251409463232602 no 2573 0.251520942419021 3651 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1440 4100-1550 40 µM -0.670258556792661 0.251237139357807 no 2574 0.251346490581801 3638 742806 SGTC_545 4218-0007 221 µM -0.671844705330884 0.250738089742265 no 2575 0.250841282535614 3600 2840508 SGTC_1353 1498-1206 8.11 µM -0.673505616304259 0.250216080800675 no 2576 0.250312838462473 3678 6756808 SGTC_2967 9089538 49.85 µM -0.673517636298347 0.25021230512947 no 2577 0.250309016270974 3640 728216 SGTC_2167 5876490 200 µM -0.674994902310799 0.249748502527112 no 2578 0.24983950184314 3678 686534 SGTC_198 3454-2873 16.191 µM -0.677486565163808 0.248967255315194 no 2579 0.249048645655473 3629 710957 SGTC_2811 7967822 32.47 µM -0.677879249668516 0.248844249983317 no 2580 0.248924128823383 3651 2232244 SGTC_974 1326-0144 138 µM -0.678297141444401 0.248713384213739 no 2581 0.248791655386096 3674 5411856 SGTC_1473 k844-0725 134 µM -0.678878774819534 0.248531302623923 no 2582 0.248607337674815 3709 54682906 SGTC_2154 5570129 200 µM -0.67888007443243 0.248530895856827 no 2583 0.248606925913209 3654 673366 SGTC_2847 9005661 71.43 µM -0.681529154235171 0.247702495580301 no 2584 0.247768362868915 3558 2991449 SGTC_1395 3486-0190 4.35 µM -0.682844227974366 0.24729180398965 no 2585 0.247352639481089 3671 6748079 SGTC_2022 5136654 200 µM -0.683605151733025 0.247054337301433 no 2586 0.247112265339534 3644 1713771 SGTC_1017 4239-0030 168 µM -0.685761747684193 0.246381976995884 no 2587 0.246431680858625 3649 1149593 SGTC_1408 3909-7976 48.8 µM -0.686100984027393 0.246276302875229 no 2588 0.246324715226586 3689 24152374 SGTC_1313 1220-0047 237 µM -0.68663758015472 0.24610919964708 no 2589 0.246155570319543 3673 3528706 SGTC_588 3970-1144 52.9 µM -0.687422870142588 0.245864759482298 no 2590 0.245908144888237 3586 1888707 SGTC_2784 7567673 72.73 µM -0.689119322946426 0.245337143364244 no 2591 0.245374090536196 3678 3471247 SGTC_2644 guaiazulene 100 µM -0.690105673755956 0.245030657055921 no 2592 0.24506386771153 3677 3515 A coloring agent. SGTC_1186 1319-0216 26 µM -0.690346339903611 0.244955906739608 no 2593 0.244988206457853 3705 4565136 SGTC_296 1222-0039 74.9 µM -0.691243002867636 0.244677513467125 no 2594 0.244706421881645 3614 5984176 SGTC_1896 st058441 89 µM -0.692520888587932 0.244281053874468 no 2595 0.244305136307783 3644 688759 SGTC_2122 5258151 111.688 µM -0.692664414031147 0.244236547246151 no 2596 0.244260088176595 3660 2173356 SGTC_842 0271-0008 11.1 µM -0.693047387771702 0.244117810119435 no 2597 0.244139906659995 3715 1221709 SGTC_3250 9135583 49.47 µM -0.694368304504689 0.24370851223463 no 2598 0.243725632734671 3680 7699353 SGTC_1732 st034308 51.822 µM -0.695043845912194 0.24349933295347 no 2599 0.243513912099707 3589 830119 SGTC_1735 st034310 56.75 µM -0.696035030013967 0.243192591531051 no 2600 0.24320344616583 3743 871153 SGTC_622 1348-1566 26.3 µM -0.697932962701372 0.242605822370233 no 2601 0.242609559467535 3716 7340407 SGTC_1618 st003135 44.5 µM -0.699488532698686 0.242125471071796 no 2602 0.242123388485983 3613 1270615 SGTC_2103 5378138 10 µM -0.699857208284532 0.24201170175374 no 2603 0.242008241726146 3712 244142 SGTC_2704 st078022 71.1 µM -0.70008759301085 0.241940622229027 no 2604 0.24193630179944 3687 54697681 SGTC_3170 9103054 49.47 µM -0.700302845369769 0.241874221657567 no 2605 0.241869097589362 3643 16432970 SGTC_2747 doxorubicin 7.63 µM -0.700995469788898 0.24166062951835 no 2606 0.241652921193018 3571 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.70169023222477 0.241446480965727 no 2607 0.241436182916312 3635 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.702473106116093 0.241205297143488 no 2608 0.24119208394982 3671 6708760 SGTC_1275 0867-0008 21.1 µM -0.702518301194364 0.24119137767186 no 2609 0.241177996285367 3666 3422836 SGTC_2055 5235184 200 µM -0.703151728392374 0.240996336628645 no 2610 0.240980599073579 3688 2836034 SGTC_2004 4023728 41.89 µM -0.704982792540787 0.240433009178507 no 2611 0.240410472370968 3669 360084 YDR527W RBA50 SGTC_689 0833-0039 98 µM -0.705198505863665 0.240366692162079 no 2612 0.240343355504786 3684 5374726 SGTC_2545 solidagenone 89.61 µM -0.70867423204834 0.239299520289925 no 2613 0.239263329487086 3526 6708572 An anti ulcer agent SGTC_2853 9015042 58.44 µM -0.710104164149429 0.23886123278111 no 2614 0.238819772118468 3641 6457456 SGTC_2891 9063876 19.48 µM -0.711129010743902 0.238547378048186 no 2615 0.238502147038186 3675 6472478 SGTC_2287 7945887 168.79 µM -0.712847512706121 0.238021601435753 no 2616 0.237970060574525 3718 1245853 SGTC_3288 9119690 36.221 µM -0.715154301186115 0.237316837982843 no 2617 0.237256851736243 3699 17595618 YKL019W RAM2 SGTC_2555 cholic acid 100 µM -0.715455202383713 0.237224992069561 no 2618 0.237163906265539 3735 6708657 Influences liver metabolism. SGTC_2935 9038016 29.96 µM -0.716121552093162 0.237021667585022 no 2619 0.236958148500447 3691 6463195 SGTC_312 4092-0653 6.84 µM -0.716293749240701 0.236969140337215 no 2620 0.236904992829623 3703 1148278 SGTC_216 k038-0035 28.382 µM -0.71641505236725 0.236932141711139 no 2621 0.236867551609356 3628 4444231 YPR107C YTH1 SGTC_2930 9013230 14.89 µM -0.716460167931515 0.23691838183817 no 2622 0.236853627144777 3690 2995857 SGTC_2774 tamoxifen 10.92 µM -0.716912995796022 0.236780297430133 no 2623 0.236713891316733 3717 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2942 9052777 62.25 µM -0.718443488036329 0.236313919992388 no 2624 0.236241940358405 3792 6469503 SGTC_237 nikkomycin 200 µM -0.71948967255114 0.235995413915757 no 2625 0.235919631587338 3731 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2227 7312221 64.1025 µM -0.720285600212164 0.235753255927231 no 2626 0.235674584434356 3730 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1624 st003710 6.25 µM -0.722047626474372 0.23521765382641 no 2627 0.235132598270178 3719 24207033 SGTC_2086 5274770 176.623 µM -0.722702819038566 0.235018666827818 no 2628 0.234931241630898 3741 689278 SGTC_736 0958-0254 92.6 µM -0.723548148203498 0.234762071345622 no 2629 0.234671592216259 3766 6812352 SGTC_2072 5231554 129 µM -0.724778290809794 0.234388944490669 no 2630 0.234294028011036 3769 789545 SGTC_3158 9100007 49.47 µM -0.727181010714569 0.233661098887248 no 2631 0.233557538646928 3726 19297233 SGTC_3285 9112818 20.8695 µM -0.72763973476181 0.23352228217844 no 2632 0.233417075189919 3741 17017947 YPR165W RHO1 SGTC_3322 9139058 2.11 µM -0.729367252747626 0.232999920267043 no 2633 0.232888521861588 3811 4908926 YPR165W RHO1 SGTC_1379 2144-0755 36.5 µM -0.729838532915509 0.232857528672809 no 2634 0.232744443976029 3767 5392327 SGTC_416 estradiol valerate 100 µM -0.732478700497137 0.232060728704851 no 2635 0.23193821923211 3749 13791 A steroid. SGTC_904 1141-0088 396 µM -0.73249702015134 0.232055205159112 no 2636 0.231932630420247 3690 1378119 SGTC_2044 5102272 200 µM -0.732865667702985 0.231944070058334 no 2637 0.231820182348422 3717 592666 SGTC_909 3448-9333 149 µM -0.73366777595736 0.231702363259569 no 2638 0.231575621293529 3679 3344074 SGTC_3074 9116018 49.47 µM -0.734261949151132 0.231523406011351 no 2639 0.23139455194496 3772 17027303 SGTC_1608 st001473 40.5 µM -0.734488563505458 0.231455173014762 no 2640 0.231325513905419 3695 7292267 SGTC_2927 9011802 47.9 µM -0.735646758253046 0.231106618714783 no 2641 0.230972849459092 3734 43912568 SGTC_2517 totarol 10 µM -0.737333212210788 0.23059961102863 no 2642 0.230459869890514 3715 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3203 9113543 49.47 µM -0.738298416209014 0.230309716466006 no 2643 0.230166564358413 3797 17018012 SGTC_827 3253-0474 693 µM -0.738920843329121 0.230122881491732 no 2644 0.229977532434155 3732 5402065 SGTC_2128 5255449 168.493 µM -0.742146496814839 0.229155991393232 no 2645 0.228999290463994 3748 736008 SGTC_1870 st057514 26.5 µM -0.742547460277768 0.229035961954359 no 2646 0.228877853871538 3746 5393161 SGTC_251 melphalan 456.522 µM -0.744349542848507 0.228496939635012 no 2647 0.228332518030004 3806 460612 A DNA alkylator. SGTC_1351 1496-0003 46.5 µM -0.744791461022815 0.228364866037394 no 2648 0.228198898880435 3770 3891978 SGTC_3229 9132204 49.47 µM -0.747070127214197 0.227684535229278 no 2649 0.227510615569028 3748 17682924 SGTC_2383 9036125 200 µM -0.748286868405828 0.22732172623485 no 2650 0.227143571734528 3682 79580 SGTC_1030 k029-0042 36.7 µM -0.751584203917709 0.226340163031201 no 2651 0.226150572776199 3763 6080581 SGTC_1765 st044815 90.4 µM -0.75213870939758 0.226175331223773 no 2652 0.225983823669858 3788 645695 SGTC_2997 9067075 71.4286 µM -0.753090105069021 0.225892678280775 no 2653 0.225697885024304 3801 27209819 SGTC_2364 9055074 200 µM -0.753192969316572 0.225862130008428 no 2654 0.225666981800365 3771 6470630 SGTC_2773 thioridazine 9.09 µM -0.753226362960321 0.225852213380685 no 2655 0.225656949954282 3780 5452 An antipsychotic. SGTC_2675 theaflavin digallate 100 µM -0.753524949599794 0.225763555577938 no 2656 0.225567262206771 3729 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1559 coumarin 343 70.1 µM -0.7542732617973 0.225541449580481 no 2657 0.225342577123212 3752 108770 A hepatotoxic, DNA x-linker. SGTC_3353 9151644 39.2805 µM -0.755302236439733 0.225236242403855 no 2658 0.225033828549829 3809 4909158 SGTC_2780 5215298 71.43 µM -0.755373296342051 0.225215173757227 no 2659 0.225012515552028 3759 2834131 SGTC_230 MPP+ 141.667 µM -0.758175459349717 0.224385247082645 no 2660 0.224172975236866 3759 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1079 idarubicin 2.36 µM -0.758387944132131 0.224322385586483 no 2661 0.224109386505808 3728 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_888 0916-0002 6.97 µM -0.758653956657256 0.224243702537335 no 2662 0.224029793370916 3855 2802138 YIL048W NEO1 SGTC_903 1134-0042 114 µM -0.75890114324948 0.224170602002757 no 2663 0.223955847506311 3764 701009 SGTC_2221 6807166 181.081 µM -0.759712832847052 0.223930656097743 no 2664 0.223713128140634 3708 674925 SGTC_88 0180-0332 8.668 µM -0.760169642953568 0.22379568134764 no 2665 0.22357659410849 3834 3101745 SGTC_1412 3909-8563 178 µM -0.760816314520341 0.223604686881142 no 2666 0.223383394245052 3850 23767530 SGTC_1023 4482-3888 16 µM -0.763787405830541 0.222728367229596 no 2667 0.222496971603861 3763 3303168 SGTC_2468 5987765 72.9 µM -0.765584165873479 0.222199366268681 no 2668 0.221961884480399 3813 26772094 SGTC_2079 5212404 121 µM -0.768363391649183 0.221382522324463 no 2669 0.221135661560789 3739 758462 SGTC_1692 fluoroquinolonic acid 71 µM -0.768567526767918 0.221322592614567 no 2670 0.22107504464416 3815 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2532 xanthone 78.9 µM -0.773947210691973 0.219746579866336 no 2671 0.21948100470485 3728 7020 An insecticide. SGTC_2131 toluylene red 5.2905 µM -0.77398874239647 0.219734438003584 no 2672 0.219468724294335 3799 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2973 9094665 17.96 µM -0.774671368785773 0.219534926244854 no 2673 0.219266936698739 3855 25237061 YIL048W NEO1 SGTC_861 0443-0273 110 µM -0.774861182806156 0.219479467644656 no 2674 0.219210845729253 3826 6149169 SGTC_933 2914-0560 114 µM -0.776552208534742 0.218985750341941 no 2675 0.218711503573185 3818 463887 SGTC_414 piperonyl butoxide 100 µM -0.776593871769819 0.218973594278479 no 2676 0.218699209126019 3779 5794 A potent inhibitor of cytochrome P450. SGTC_1081 sertraline 6 µM -0.776643302194678 0.218959172488949 no 2677 0.218684623166716 3798 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3022 9087993 49.47 µM -0.776795691545879 0.218914714906733 no 2678 0.218639659550024 3817 17173644 SGTC_2751 anetholtrithion 17.25 µM -0.778328521090936 0.218467821012066 no 2679 0.218187682820232 3807 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_629 3448-6466 76.7 µM -0.778841670806538 0.218318330531693 no 2680 0.218036493665603 3801 573744 SGTC_828 2074-0507 139 µM -0.780123077673457 0.217945289237949 no 2681 0.217659216946101 3863 X828 SGTC_279 1273-0055 2.93 µM -0.780204781667694 0.217921516161733 no 2682 0.217635174124404 3814 2847562 SGTC_878 0828-0289 13.7 µM -0.780531659574281 0.217826420796997 no 2683 0.217538999945412 3784 745350 YLR208W SEC13 SGTC_3081 9117243 49.47 µM -0.781746895837912 0.217473094064429 no 2684 0.217181667720956 3827 45595589 SGTC_959 1222-0044 107 µM -0.783225737329736 0.217043571408242 no 2685 0.21674728182593 3761 6083612 SGTC_720 r052-1644 49.9 µM -0.783433155821994 0.216983366893913 no 2686 0.216686396182353 3803 1422863 YOR257W CDC31 SGTC_164 4100-3994 89.624 µM -0.784157477547403 0.21677320370071 no 2687 0.216473856316469 3793 4615967 SGTC_3150 9097574 49.47 µM -0.785346350682059 0.216428505393689 no 2688 0.216125263386168 3789 17217476 SGTC_1270 0831-1170 17.3 µM -0.786492972565475 0.216096357984806 no 2689 0.215789367249753 3807 6764716 SGTC_1410 3909-8106 77.9 µM -0.786764990003321 0.216017604750411 no 2690 0.215709725769765 3836 1039210 SGTC_2912 7964298 10.93 µM -0.787077931418003 0.215927023964356 no 2691 0.215618123617105 3865 2975850 SGTC_334 1502-1024 68.5 µM -0.787496403762349 0.21580593168462 no 2692 0.215495666399269 3862 3296216 SGTC_3343 9148379 18.9835 µM -0.787798017792119 0.215718678811111 no 2693 0.21540743035419 3868 1955036 SGTC_1973 st070275 50.2 µM -0.790278447960152 0.215001899842324 no 2694 0.214682585250068 3720 17118334 SGTC_1377 2944-0135 198 µM -0.791136438546822 0.214754285475123 no 2695 0.214432188802256 3871 1894137 SGTC_2009 4012297 12.05 µM -0.791271999017283 0.214715178158283 no 2696 0.214392642301025 3834 45595307 SGTC_651 3253-0966 34.4 µM -0.791815645359333 0.214558385305848 no 2697 0.214234089196759 3842 781462 SGTC_745 0469-0705 296 µM -0.792788690879486 0.214277915824368 no 2698 0.213950473269608 3887 3486736 SGTC_1603 st002045 67.8 µM -0.79416779348511 0.213880770491869 no 2699 0.213548877570921 3817 5887985 SGTC_1342 1486-1464 234 µM -0.794519309207665 0.213779611779563 no 2700 0.213446586225821 3852 3253938 SGTC_134 0269-0018 6.916 µM -0.795479502652627 0.213503430681998 no 2701 0.213167314790794 3779 4378915 SGTC_152 4469-0003 551.229 µM -0.79548134492821 0.213502900986948 no 2702 0.213166779171449 3760 697280 SGTC_359 0081-0058 15.9 µM -0.795887314983033 0.213386194281615 no 2703 0.213048767434157 3828 3494159 SGTC_957 1187-1561 14.1 µM -0.797082328434826 0.213042872349347 no 2704 0.212701609391548 3790 1538454 SGTC_881 0833-0569 170 µM -0.798033614516742 0.212769802705069 no 2705 0.212425491771742 3840 5418700 SGTC_2551 apiole 73.87 µM -0.799188781314666 0.21243848333252 no 2706 0.212090478030286 3654 10659 A possible DNA adduct former. SGTC_864 0469-0573 172 µM -0.799919555131688 0.212229042057988 no 2707 0.211878703532082 3818 689425 SGTC_780 0109-0199 192 µM -0.800868020830986 0.211957389910015 no 2708 0.211604027600812 3882 610414 SGTC_1051 3253-3903 78 µM -0.800971137884673 0.211927868190513 no 2709 0.2115741774418 3825 5509239 SGTC_741 4582-0002 126 µM -0.802061518768989 0.211615846685851 no 2710 0.211258686621407 3793 2912688 SGTC_2099 5377090 177.372 µM -0.802070601541368 0.211613248705314 no 2711 0.211256059769965 3865 2243829 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.802309940180253 0.211544796476588 no 2712 0.211186846936593 3777 140250 A respiratory chain inhibitor. SGTC_2180 6301957 200 µM -0.804086801823417 0.211037009354392 no 2713 0.210673423162838 3781 845462 SGTC_824 1304-0008 100 µM -0.804519128904799 0.210913568145913 no 2714 0.210548613201821 3868 768245 SGTC_636 0kpi-0074 126 µM -0.808847913763012 0.209679917725062 no 2715 0.209301316074872 3868 616434 SGTC_2988 9073640 71.4286 µM -0.809056327726461 0.209620629569744 no 2716 0.209241373560444 3879 9102229 SGTC_1233 0325-0408 14.2 µM -0.809180204570545 0.209585394618578 no 2717 0.209205749788671 3905 12874 SGTC_460 trequinsin 123 µM -0.809398764415462 0.20952323697235 no 2718 0.209142906345907 3876 5537 A vasodilator. SGTC_3312 9133330 71.43 µM -0.809486756054182 0.209498215523853 no 2719 0.209117608873875 3908 17617324 SGTC_2961 9083290 32.55 µM -0.809516431852283 0.209489777261044 no 2720 0.209109077530083 3800 17741490 SGTC_1212 0520-0165 585 µM -0.810934441982269 0.209086801586732 no 2721 0.208701659948019 3930 5403258 SGTC_3069 9117009 49.47 µM -0.811291344333681 0.208985447626906 no 2722 0.208599189789359 3787 41904981 SGTC_2164 5685496 200 µM -0.811570075388028 0.208906313062436 no 2723 0.208519184006225 3786 759046 SGTC_1962 st076595 64.5 µM -0.811756330738183 0.208853443125948 no 2724 0.20846573214433 3859 279619 SGTC_2446 5162541 200 µM -0.814275433240068 0.208139152229829 no 2725 0.207743590045726 3812 1549321 SGTC_997 3996-0078 137 µM -0.815272004799494 0.207856973074756 no 2726 0.207458314855504 3886 735687 SGTC_406 estrone 100 µM -0.815294462378043 0.207850616817202 no 2727 0.207451888894302 3824 5870 A steroid. SGTC_411 enrofloxacin 100 µM -0.817817724818822 0.207137179091806 no 2728 0.206730637743085 3941 71188 A bacterial gyrase inhibitor. SGTC_938 3126-1755 342 µM -0.817961951555259 0.207096443636909 no 2729 0.206689456775713 3893 1777771 SGTC_2074 5212007 75.395 µM -0.819250659566979 0.206732670860331 no 2730 0.206321708468495 3727 758611 SGTC_297 0986-0032 24 µM -0.820611290157269 0.206349006875255 no 2731 0.205933857338528 3827 2847425 SGTC_1435 4092-0789 56.7 µM -0.821212039679739 0.206179744817859 no 2732 0.205762749916062 3845 2248285 SGTC_1323 1348-1351 11.2 µM -0.82274435466005 0.205748385724477 no 2733 0.205326693213499 3817 6989654 SGTC_91 0417-1751 58.384 µM -0.824406408782655 0.205281110022353 no 2734 0.204854337295629 3961 6795624 SGTC_1527 coumarin 137 µM -0.826793751539687 0.204611028397642 no 2735 0.204176986125008 3991 323 A hepatotoxic, DNA x-linker. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.827677685157771 0.204363255577513 no 2736 0.203926529949583 3962 688801 SGTC_2126 5251174 33.877 µM -0.828794232568655 0.204050534915809 no 2737 0.203610426167832 3871 790722 SGTC_567 1080-0542 68.4 µM -0.829901559777494 0.20374067836627 no 2738 0.203297221472639 3776 5950415 SGTC_1930 st074634 34.3 µM -0.830121437383888 0.203679184767362 no 2739 0.203235063879851 3803 684253 YOR116C RPO31 SGTC_2408 sulbentine 18.36 µM -0.83031095951852 0.203626189623715 no 2740 0.203181496632662 3872 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2370 9071495 200 µM -0.832046140123346 0.203141371971275 no 2741 0.202691450605765 3901 21791103 SGTC_2823 7987624 58.44 µM -0.834349650807792 0.202498825927493 no 2742 0.202041990341418 3873 2239440 SGTC_1477 0139-0234 16 µM -0.835512285689834 0.202174980074996 no 2743 0.201714666262495 3896 620880 SGTC_3174 9107204 49.47 µM -0.839325721252079 0.201114944648147 no 2744 0.200643276662696 3926 3938802 SGTC_2020 4017018 200 µM -0.844010031187936 0.199817400972069 no 2745 0.199331900087999 3977 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_644 1498-1197 63.3 µM -0.844160306454128 0.199775858580527 no 2746 0.199289916016316 3954 6741615 SGTC_606 k015-0008 38.6 µM -0.8444030319412 0.199708770041127 no 2747 0.199222114346747 3943 1970475 SGTC_381 3461-2219 42.7 µM -0.844698665939437 0.199627076071423 no 2748 0.199139552258565 3868 2883159 SGTC_2097 5376186 200 µM -0.845521666693031 0.199399758236128 no 2749 0.198909820358193 3836 742755 SGTC_3168 9103419 49.47 µM -0.846620842546852 0.199096402327668 no 2750 0.198603246370173 3861 16649256 SGTC_2788 5282734 71.43 µM -0.848226360911132 0.198653803541056 no 2751 0.198155959566438 3968 743706 SGTC_1100 amiodarone 5.07 µM -0.848286652129538 0.198637194420526 no 2752 0.198139174688174 3983 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_379 3970-0972 5.9 µM -0.848705354744284 0.198521872664492 no 2753 0.198022632929918 3898 2898042 YBL034C STU1 SGTC_3300 9124615 50.48 µM -0.849199901270125 0.198385713529273 no 2754 0.197885034100969 3960 24824903 SGTC_2593 nobiletin 86.24 µM -0.850443273431814 0.198043635859728 no 2755 0.197539343023533 3917 72344 An anti-infammatory. SGTC_1474 0330-0125 5.35 µM -0.851070147673557 0.197871304800462 no 2756 0.197365193559162 3898 X1474 SGTC_2017 5132927 60.65 µM -0.851472126588935 0.197760846347155 no 2757 0.197253570257052 3932 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3247 9135149 49.47 µM -0.852171249105761 0.197568825564915 no 2758 0.197059525785311 3880 8934436 YOR116C RPO31 SGTC_772 k072-0172 35.3 µM -0.853001729244082 0.197340872663004 no 2759 0.196829172624832 3953 5861980 SGTC_1021 4476-0760 85.3 µM -0.853312576584609 0.197255591199926 no 2760 0.196742993771456 3944 746768 SGTC_1507 4075-3230 155 µM -0.853522315299052 0.197198061648155 no 2761 0.196684859036274 3793 659771 SGTC_1195 1502-0147 41.1 µM -0.854173844467902 0.197019417475004 no 2762 0.196504336548208 3893 817940 SGTC_788 1182-0090 188 µM -0.854267512949185 0.19699374237018 no 2763 0.196478391604676 3994 5715185 SGTC_2206 7254556 146.969 µM -0.856329416004168 0.196429075215435 no 2764 0.195907797369293 3928 4398905 SGTC_2603 homopterocarpin 100 µM -0.862838622923774 0.194652928201846 no 2765 0.19411310022401 3966 101795 A weak amylase inhibitor. SGTC_2337 9009472 200 µM -0.865381895795074 0.19396161655695 no 2766 0.193414607200427 3875 5742383 SGTC_875 0709-0210 25.7 µM -0.865716257187151 0.193870841954693 no 2767 0.19332289125198 3916 6251364 SGTC_2179 6298986 200 µM -0.865968777945174 0.19380230314432 no 2768 0.19325364193452 3868 738374 SGTC_2563 tomatine 8.54 µM -0.867501369687363 0.19338664630245 no 2769 0.192833680817372 3820 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1015 4130-4525 82 µM -0.867632539257005 0.193351096864453 no 2770 0.192797763621758 3926 1363237 SGTC_1922 5578187 25 µM -0.868292734946899 0.193172231876651 no 2771 0.192617049167723 3933 1350412 SGTC_1210 3013-0140 750 nM -0.868318735008198 0.193165189819976 no 2772 0.192609934326341 3963 905973 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.868625225597593 0.193082189362544 no 2773 0.192526076172477 3953 5282309 SGTC_3290 9121031 71.43 µM -0.869811995938367 0.192761006537497 no 2774 0.192201577367661 3936 17014854 SGTC_2796 7949634 45.45 µM -0.871639501673838 0.192267056439323 no 2775 0.191702536945718 3884 2971588 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.871953917522744 0.192182152207958 no 2776 0.19161675889251 3982 5377381 SGTC_939 1165-0479 45.3 µM -0.872028928594251 0.192161899756488 no 2777 0.191596298055515 3888 1377347 SGTC_2636 apigenin dimethyl ether 100 µM -0.873511222720249 0.19176195885114 no 2778 0.191192245929572 3955 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1993 st073995 70.8 µM -0.876242093576878 0.191026472533601 no 2779 0.19044921873668 3920 3098394 SGTC_2166 5933061 31.504 µM -0.87886839393792 0.190320783819115 no 2780 0.18973631868843 4026 2877375 SGTC_322 k048-0136 19.3 µM -0.883400558128336 0.189106760171515 no 2781 0.188509944668138 4004 6823282 SGTC_1632 st005650 90 µM -0.887842641288451 0.18792150573917 no 2782 0.187312701053153 3985 2759605 SGTC_506 n9-isopropylolomoucine 153 µM -0.888645764052591 0.187707703949763 no 2783 0.187096743869661 3947 6610355 SGTC_2687 chenodiol 100 µM -0.890039794175568 0.187336951822754 no 2784 0.186722259389504 4036 5702181 A cholesterol synthesis inhibitor. SGTC_2965 9082772 38.63 µM -0.891269989124768 0.187010149125785 no 2785 0.186392172369447 3965 16459634 SGTC_1611 st001856 99.4 µM -0.891725704990182 0.186889177263354 no 2786 0.186269986088587 3941 647478 SGTC_1172 0370-0043 85 µM -0.892474289806099 0.186690567129666 no 2787 0.18606938370228 4009 376585 SGTC_2877 9040724 71.43 µM -0.89277749726163 0.186610159100186 no 2788 0.185988169655991 3932 6463895 SGTC_727 3032-0951 202 µM -0.893098843116296 0.186524964331891 no 2789 0.185902121236942 3969 3652836 SGTC_449 xestospongin c 11.1929 µM -0.894112676560043 0.186256336124828 no 2790 0.18563080373061 3973 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1663 st014140 55.4 µM -0.895269364395567 0.185950149745787 no 2791 0.185321556415183 4037 4207120 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.896928879807423 0.185511405537756 no 2792 0.184878434230457 3957 688751 SGTC_2222 6885208 172.143 µM -0.897806907395915 0.185279531908446 no 2793 0.184644250751219 3893 609514 SGTC_2283 7944793 200 µM -0.8988436297435 0.185005981231506 no 2794 0.184367978515568 4006 2970533 SGTC_2764 methyldopa 94.69 µM -0.898972037624491 0.184972116863054 no 2795 0.184333777491479 3954 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2243 6634756 200 µM -0.899086769876563 0.184941862358189 no 2796 0.184303222266445 4056 885676 SGTC_2771 fluoxetine 41.05 µM -0.904117380935226 0.183618331817639 no 2797 0.182966581497148 3957 3386 A selective serotonin reuptake inhibitor. SGTC_1326 1431-2094 10.8 µM -0.904375951518333 0.183550462954909 no 2798 0.182898042755627 3960 616278 SGTC_3039 9090270 49.47 µM -0.905039738805784 0.183376305573518 no 2799 0.182722167482421 3972 17173750 SGTC_510 ag-490 170 µM -0.907802109956098 0.18265265131743 no 2800 0.181991391714025 4095 5328779 SGTC_1185 1319-0113 81.3 µM -0.909145333637387 0.182301414264379 no 2801 0.181636707825411 4050 4672763 SGTC_2857 9024691 58.44 µM -0.911605777994868 0.181659132752441 no 2802 0.180988139833578 4071 16478292 SGTC_2075 5212009 200 µM -0.912717142294568 0.181369483808614 no 2803 0.180695662891847 3874 780898 SGTC_603 3794-0023 45.9 µM -0.913155668597013 0.181255272643688 no 2804 0.180580337823966 3989 3802260 SGTC_537 1334-0398 209 µM -0.913700717263361 0.18111338125714 no 2805 0.180437063517528 3998 5846986 SGTC_2794 7785382 27.27 µM -0.915078253091294 0.18075508049228 no 2806 0.180075275324442 3914 2205081 SGTC_1531 st059297 52.4 µM -0.918869350338416 0.17977130232798 no 2807 0.179081956522053 4003 7566702 SGTC_515 4092-1064 102 µM -0.919075927939463 0.179717792884597 no 2808 0.179027929612658 4024 717353 SGTC_845 0330-0138 4.51 µM -0.921526946510861 0.179083673639469 no 2809 0.178387689666875 3954 9039800 SGTC_3147 9097027 49.47 µM -0.923974266344387 0.178451917599453 no 2810 0.177749857078567 4016 25236841 SGTC_109 0132-0036 33.701 µM -0.924464449095422 0.178325549808503 no 2811 0.177622276387234 3808 67274 A color developer. SGTC_1475 4092-1048 11.7 µM -0.924940320482229 0.178202925403828 no 2812 0.177498475832993 4023 2881759 SGTC_2281 7943571 200 µM -0.92775268508653 0.177479309851501 no 2813 0.176767936259351 4105 1244024 SGTC_1953 st076800 12.1 µM -0.928957398254793 0.177169907895003 no 2814 0.17645558240313 4026 297591 SGTC_422 cantharidin 155 µM -0.931191515600349 0.176597030305694 no 2815 0.175877252948864 3941 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1753 st043925 64 µM -0.932855229520494 0.176171178766819 no 2816 0.175447360373922 4067 670181 SGTC_1119 parthenolide 318.541 nM -0.937408151454983 0.17500911943491 no 2817 0.174274324761475 4128 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3108 9121785 49.47 µM -0.937635141206227 0.174951311549171 no 2818 0.174215972803398 3869 17140271 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.938686033100802 0.174683836956061 no 2819 0.173945983234744 4055 4174840 SGTC_1200 1643-0193 18.4 µM -0.939972130951931 0.174356850879928 no 2820 0.17361592804308 4020 5403974 SGTC_1795 st049545 62.3 µM -0.940258082207141 0.17428420160571 no 2821 0.173542597689815 3935 5291882 SGTC_2345 9052315 157.45 µM -0.940463508265186 0.174232022577564 no 2822 0.173489929671497 4067 6469265 SGTC_2432 5630864 12.22 µM -0.941974445542576 0.173848543643352 no 2823 0.173102861695782 4076 5714970 SGTC_1499 4480-0877 67.3 µM -0.944881666345398 0.173112196500816 no 2824 0.172359646203286 3944 2861909 SGTC_1367 1812-0510 76.9 µM -0.945926717807489 0.172847989725065 no 2825 0.172092982499544 4060 1142582 YDR527W RBA50 SGTC_1509 1326-1131 80 µM -0.946401469040729 0.172728049475602 no 2826 0.171971928204138 3943 768313 SGTC_1570 verbenone 133 µM -0.94694073130266 0.172591875655235 no 2827 0.171834490548126 4054 29025 A natural terpanoid with antifungal properties. SGTC_1241 0364-0022 50.8 µM -0.947252968560221 0.172513061200559 no 2828 0.17175494509589 4050 4563895 SGTC_3200 9114385 49.47 µM -0.947842828666894 0.172364232255596 no 2829 0.171604736741932 4089 17018030 YLR208W SEC13 SGTC_2120 5538279 151.968 µM -0.947914376894641 0.172346185331254 no 2830 0.171586522637181 4000 2058197 SGTC_2048 5246248 200 µM -0.948246396871095 0.172262454248246 no 2831 0.171502016142336 4036 677046 SGTC_491 tetrandrine 80.3 µM -0.949650722719925 0.171908588813551 no 2832 0.171144878086601 4044 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1688 st021091 57.6 µM -0.952456312948888 0.171203020404169 no 2833 0.170432805926515 4041 3656366 SGTC_2685 mycophenolic acid 18.85 µM -0.953544766563415 0.170929788143621 no 2834 0.170157062804906 4004 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_585 0kpi-0023 191 µM -0.95374220850225 0.17088025461243 no 2835 0.170107074549972 3970 64601 SGTC_2906 7926292 26.41 µM -0.954855182778479 0.170601207419099 no 2836 0.169825468333145 4061 2966319 SGTC_1773 st048542 73.5835 µM -0.954990691897008 0.170567252228554 no 2837 0.169791202063019 3989 3237138 SGTC_2956 9076196 2.52 µM -0.957705980916461 0.169887780982043 no 2838 0.169105520003757 4064 16423868 SGTC_3000 9075062 71.4286 µM -0.957824683115154 0.169858116705836 no 2839 0.169075585192008 3983 17057871 SGTC_987 1497-1013 404 µM -0.959079566037409 0.169544718317563 no 2840 0.168759331794821 3995 1676435 SGTC_172 1112-0046 2.638 µM -0.964422516308654 0.168214508978381 no 2841 0.167417069016159 4022 2802135 YIL048W NEO1 SGTC_661 1304-0007 33.6 µM -0.965574569119061 0.167928570077824 no 2842 0.167128552869546 4050 3117130 SGTC_1472 k841-0093 193 µM -0.966190058493454 0.167775934242211 no 2843 0.16697454328685 4153 X1472 SGTC_786 4544-0069 423 µM -0.967568066693765 0.167434524589749 no 2844 0.166630065949801 4060 748821 YLR208W SEC13 SGTC_170 4197-0004 226 µM -0.970775514171324 0.166641595482095 no 2845 0.16583003918544 4095 218692 SGTC_1919 st067113 52.3 µM -0.971650855881426 0.166425619508632 no 2846 0.165612136563303 4097 1268243 SGTC_1197 1601-0112 267 µM -0.972438776706298 0.166231367805569 no 2847 0.165416154427407 4029 7350313 SGTC_2835 9006588 71.43 µM -0.972592325552321 0.166193529377787 no 2848 0.165377979194593 4135 2345538 SGTC_209 4077-0173 175.592 µM -0.972944466758143 0.166106773641186 no 2849 0.165290451562549 4035 15993494 SGTC_309 k408-0051 1.48 µM -0.973638103501332 0.1659359704966 no 2850 0.165118130065401 4000 3640463 SGTC_2913 7966556 36.57 µM -0.974647983523372 0.165687497685531 no 2851 0.164867451640323 3922 2976516 SGTC_2404 5161160 200 µM -0.974944005337185 0.16561470953126 no 2852 0.164794018084265 4019 2831543 SGTC_2138 5575593 77.673 µM -0.978150879585616 0.164827503985786 no 2853 0.163999853296819 4036 762213 SGTC_183 3914-0051 30.55 µM -0.979226023122565 0.164564127135957 no 2854 0.163734156611676 4100 1596232 SGTC_1394 3474-0001 65.7 µM -0.979660627457828 0.164457739989964 no 2855 0.163626833620599 4051 5017666 YIL048W NEO1 SGTC_2207 7258803 200 µM -0.981120204848693 0.164100775212809 no 2856 0.163266733900346 4025 3666799 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.983137830130269 0.163608158410068 no 2857 0.162769803859679 4048 641818 YHR062C RPP1 SGTC_1908 st060353 56.5 µM -0.984114583748454 0.163370022721999 no 2858 0.162529588549658 4135 4227716 SGTC_3249 9135183 49.47 µM -0.987273320134891 0.162601454865719 no 2859 0.161754333151995 4083 4902779 SGTC_2715 st079500 56.4 µM -0.987707520973753 0.162495991499521 no 2860 0.161647955024123 4029 28246688 SGTC_2359 9039622 200 µM -0.991095261976113 0.161674669434541 no 2861 0.160819533172523 4033 6463596 SGTC_2910 7948405 25.97 µM -0.99140076211793 0.161600737382061 no 2862 0.160744964133179 3996 2971328 SGTC_169 k015-0017 16.025 µM -0.996965393184728 0.160257935662066 no 2863 0.159390654074133 4040 1840002 SGTC_2030 5175110 200 µM -0.99893957328566 0.159783303716478 no 2864 0.158911982200422 4125 2831986 SGTC_2646 retinol 96.75 µM -1.00041572778503 0.159429008506104 no 2865 0.158554680887962 4101 445354 A vitamin A analog and teratogen. SGTC_2255 7941087 197.44 µM -1.00128618607291 0.159220329070963 no 2866 0.158344234698487 4179 935561 SGTC_58 0957-0393 9 µM -1.00441177115374 0.158472491653694 no 2867 0.157590089287127 3884 6997992 SGTC_3221 9128209 49.47 µM -1.00542060839399 0.158231606667834 no 2868 0.157347180285977 4121 16460723 SGTC_284 0988-0104 32.6 µM -1.00554736316542 0.158201357813573 no 2869 0.157316677539435 4079 4666532 SGTC_394 menadione 8.33 µM -1.0065625272102 0.157959235212907 no 2870 0.157072524878348 4081 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2053 5265679 138 µM -1.00713307134016 0.157823263931492 no 2871 0.156935415259843 4024 764595 SGTC_2279 7948423 32.93 µM -1.00789977274535 0.157640665811248 no 2872 0.156751290380374 4055 1247112 SGTC_2864 9034755 47.6 µM -1.00828151889415 0.157549800671644 no 2873 0.156659666316102 4048 4930451 SGTC_222 nsc-310342 10.666 µM -1.00924639009004 0.157320290627462 no 2874 0.156428241806895 4096 432556 SGTC_499 genistein 192 µM -1.01058822179218 0.157001480051254 no 2875 0.156106777702417 4153 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_897 1000-0139 31.4 µM -1.01081525198091 0.156947581204943 no 2876 0.156052430917047 4050 6151020 SGTC_112 phenothiazine 287.218 µM -1.0108691976854 0.156934775838204 no 2877 0.156039519156925 4028 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2876 9059903 25.97 µM -1.01155036844946 0.156773142000768 no 2878 0.155876543330754 4077 6916095 SGTC_2981 9013952 38.96 µM -1.01281218031596 0.156474018377138 no 2879 0.155574940820678 4075 2996344 SGTC_2438 5259590 200 µM -1.01454857134384 0.156063006397838 no 2880 0.155160532556021 4122 1201127 SGTC_2308 7584454 197.62 µM -1.01497661329075 0.155961796252283 no 2881 0.155058487840446 4174 893577 SGTC_2219 9098279 200 µM -1.01500421700619 0.155955270863115 no 2882 0.155051908667295 4038 902349 SGTC_2700 st077718 96.8 µM -1.01530148895934 0.155885008569231 no 2883 0.154981067435835 4098 904970 SGTC_1251 0490-5699 265 µM -1.01804325637521 0.155237956724717 no 2884 0.154328699869988 4164 3883818 SGTC_3071 9117417 49.47 µM -1.01946553444288 0.154903001177737 no 2885 0.153991003779979 4061 45595590 YGL055W OLE1 SGTC_734 2023-0417 80 µM -1.02107720891517 0.15452401894027 no 2886 0.153608930051028 4104 3935732 SGTC_813 k007-0158 173 µM -1.02155152271254 0.154412601761284 no 2887 0.153496605880237 4095 6523916 SGTC_3005 9076496 71.4286 µM -1.02299495003926 0.154073864868686 no 2888 0.153155116753615 4082 21368410 SGTC_3308 9128332 17.569 µM -1.02331271914053 0.153999358351866 no 2889 0.153080005934981 4130 17332805 YDL196W YDL196W SGTC_2540 epiandrosterone 100 µM -1.0238642738463 0.153870093324445 no 2890 0.152949693385643 4152 441302 A steroid. SGTC_320 4092-0846 5.34 µM -1.02518376503836 0.153561142455894 no 2891 0.152638243570582 4082 1359356 SGTC_1628 st004252 77.7 µM -1.02553559049697 0.153478834074064 no 2892 0.15255527055603 4148 692968 SGTC_2372 9071633 200 µM -1.02719951571992 0.153089960313941 no 2893 0.152163263053715 4143 21321366 SGTC_3124 9127567 49.47 µM -1.02858952040832 0.152765605251644 no 2894 0.151836302249057 4118 17592030 SGTC_943 3253-1379 105 µM -1.0299571308346 0.152446921002057 no 2895 0.151515064993656 4155 668464 SGTC_1089 terbinafine 2.25 µM -1.03027084742088 0.152373880177621 no 2896 0.151441440038078 4129 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_308 4092-1169 104 µM -1.03204151602786 0.15196206120521 no 2897 0.151026334648903 4055 2268590 YDL196W YDL196W SGTC_1752 st044819 83.042 µM -1.03332557861473 0.151663879112236 no 2898 0.150725780466977 4119 441209 YML126C ERG13 SGTC_1022 4477-0945 21.3 µM -1.03522222536044 0.151224156004017 no 2899 0.150282570794075 4082 4648966 SGTC_1128 3448-9350 235 µM -1.03676109559586 0.150868004466726 no 2900 0.149923605422239 4189 619386 SGTC_1444 4112-3581 28 µM -1.03726166441507 0.150752274759903 no 2901 0.149806963324051 4159 2877249 SGTC_3043 9092303 49.47 µM -1.03989187413226 0.150145151208595 no 2902 0.149195069058429 4132 25236084 SGTC_2249 haloperidol 116.36 µM -1.04664600212271 0.148593591482698 no 2903 0.147631438390658 4123 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_944 3370-0224 231 µM -1.049220882572 0.14800492170776 no 2904 0.147038234820523 4178 4580514 SGTC_1842 st055362 61.2 µM -1.05008682219438 0.147807301605713 no 2905 0.146839098413748 4116 676032 SGTC_1198 1612-1005 86.7 µM -1.05066012752991 0.147676562184917 no 2906 0.146707357437127 4215 6998509 SGTC_1010 4112-3296 15.2 µM -1.05196438449508 0.147379421494573 no 2907 0.146407945145098 4223 704384 SGTC_2539 epi(13)torulosol 80 µM -1.05214272300301 0.147338822908919 no 2908 0.146367036696815 4173 6708597 SGTC_133 0724-0033 378.92 µM -1.05474308879222 0.146747703604143 no 2909 0.145771419649794 3980 280309 SGTC_3237 9133362 49.47 µM -1.0562285120631 0.146410749847891 no 2910 0.145431913730782 4120 43845137 SGTC_1035 k081-0041 55.2 µM -1.05778702951569 0.14605777420599 no 2911 0.145076273702641 4179 731709 SGTC_3092 9117248 49.47 µM -1.05928027652988 0.145720117828197 no 2912 0.14473607734861 4261 17141857 SGTC_1816 st051957 91.6 µM -1.06030029377537 0.145489771114016 no 2913 0.144504002820633 4136 674121 SGTC_602 3130-1533 38.1 µM -1.06159390379995 0.145197992352006 no 2914 0.144210041216701 4197 720941 SGTC_1148 3909-7663 27.7 µM -1.06311824762594 0.144854676381812 no 2915 0.143864165129357 4192 4084526 SGTC_649 1123-0311 367 µM -1.06459005840849 0.14452371107855 no 2916 0.143530740314974 4053 693629 YIL048W NEO1 SGTC_2497 7-hydroxyflavone 100 µM -1.06500471826012 0.144430558803493 no 2917 0.143436897305118 4183 5281894 SGTC_469 w7 172 µM -1.06561626347003 0.144293250589338 no 2918 0.143298572146828 4236 45115570 A P450 inhibitor. SGTC_2911 7942208 15.64 µM -1.07001145161629 0.143309002671449 no 2919 0.142307077071709 4191 1243384 SGTC_2553 4-methylesculetin 85.09 µM -1.07366871923517 0.142493466635872 no 2920 0.141485592989535 4194 5319502 SGTC_2621 lithochol-11-enic acid 100 µM -1.07399456184805 0.142420959412658 no 2921 0.141412559452025 4117 6708711 SGTC_1779 st039427 55 µM -1.07403044930292 0.142412975182355 no 2922 0.141404517291063 4127 1124498 SGTC_1020 4335-0961 93.3 µM -1.07448246821856 0.142312436072415 no 2923 0.141303249133259 4113 669075 SGTC_647 0140-0236 81 µM -1.07468199715713 0.142268071657777 no 2924 0.141258563266982 4185 990837 SGTC_2833 9001315 45.46 µM -1.07503009172162 0.142190696711002 no 2925 0.141180628053175 4132 2989378 SGTC_2526 patulin 37.61 µM -1.07694334588845 0.141765924375633 no 2926 0.140752788347961 4199 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_883 0850-0245 24.6 µM -1.079612506518 0.14117476613929 no 2927 0.140157384921751 4238 6823229 YPR165W RHO1 SGTC_2712 st079126 47.7 µM -1.08160197071803 0.140735233831004 no 2928 0.139714714232882 4173 3152970 SGTC_2851 9015922 71.43 µM -1.08192593153766 0.140663749182295 no 2929 0.139642720618499 4199 2996893 SGTC_662 k832-1615 104 µM -1.08267574281516 0.140498391624402 no 2930 0.139476187289327 4193 5878478 SGTC_931 2812-0076 566 µM -1.08412685930599 0.140178748618977 no 2931 0.139154277668568 4125 3450959 SGTC_2310 7668677 200 µM -1.08620731065428 0.139721342004999 no 2932 0.138693641807712 4199 2197143 SGTC_3066 9117245 49.47 µM -1.0889496994081 0.13911995422559 no 2933 0.138088033966836 4246 17176980 SGTC_2634 4'-methoxyflavone 100 µM -1.08914677680141 0.139076804409191 no 2934 0.138044582485428 4196 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_29 0299-0004 12.984 µM -1.08988496634408 0.138915259827822 no 2935 0.137881909871371 4073 16871 A napthoquinone isolated from Swertia calycina. SGTC_2586 curcumin 80 µM -1.09164294987646 0.138531059261411 no 2936 0.137495035044462 4108 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2499 avocadenofuran 51.48 µM -1.09400109956681 0.138016832640247 no 2937 0.136977247980691 4160 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3063 1327-0034 4 µM -1.09466805563458 0.137871630272989 no 2938 0.136831044176868 4087 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1111 tnp00062 510.699 nM -1.09498411450087 0.137802857807703 no 2939 0.136761798004469 4233 676306 SGTC_2991 9074669 71.4286 µM -1.09607666543734 0.137565305766631 no 2940 0.13652261269409 4181 17333109 SGTC_3210 9128157 49.47 µM -1.09681757293751 0.137404370283908 no 2941 0.136360573358951 4206 17590849 SGTC_2931 9014674 55.67 µM -1.09710173472563 0.137342680486542 no 2942 0.136298461000449 4147 2996810 SGTC_2649 anisomycin 9.56 µM -1.10149200597108 0.136391982497783 no 2943 0.135341290898247 4221 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2691 st077356 60.2 µM -1.10166990752875 0.136353553674881 no 2944 0.135302602045515 4241 2839272 SGTC_894 0960-0238 55.9 µM -1.10320105132414 0.136023114894158 no 2945 0.134969932444446 4191 6741907 YDL195W SEC31 SGTC_2050 5263056 171 µM -1.10369102123264 0.135917489518705 no 2946 0.134863595915177 4194 763468 YGL055W OLE1 SGTC_1768 st044301 37.178 µM -1.10522295099637 0.135587605760966 no 2947 0.134531497161898 4195 3931349 SGTC_1556 plumbagin 1.48 µM -1.10703931100993 0.135197184464668 no 2948 0.134138466258687 4118 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1810 st050138 53 µM -1.10807078261552 0.134975816108478 no 2949 0.13391562399336 4206 3444541 SGTC_683 panaxydol 45 µM -1.10898596472202 0.134779613375534 no 2950 0.133718118387875 4182 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1863 st057641 20.1 µM -1.10952909674568 0.134663265749531 no 2951 0.133600999709854 4221 3921635 SGTC_2948 9070189 9.45 µM -1.11116106955624 0.134314085690692 no 2952 0.13324951252013 4155 6473636 YDL196W YDL196W SGTC_263 alizarin 107.927 µM -1.11258613941611 0.1340096839406 no 2953 0.132943108013347 4232 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_489 paxilline 115 µM -1.11377490472825 0.133756120877564 no 2954 0.132687882750692 4197 105008 A toxic potassium channel blocker. SGTC_896 0964-0007 44.5 µM -1.11517401385657 0.13345811434033 no 2955 0.132387929748665 4173 6756758 SGTC_3305 9127027 53.8275 µM -1.1162078375681 0.133238206236677 no 2956 0.132166590207993 4140 41905295 SGTC_41 0478-0632 82.643 µM -1.11645443009627 0.13318578956458 no 2957 0.132113832960397 4166 3750424 SGTC_1365 1672-3266 55.4 µM -1.11821851341711 0.132811222999976 no 2958 0.131736839601008 4226 6415873 SGTC_818 4072-2707 53.5 µM -1.11902212567215 0.132640833303453 no 2959 0.131565349996971 4108 882871 SGTC_2223 6903751 107.57 µM -1.12063924074777 0.13229841336804 no 2960 0.131220727316714 4184 5598863 SGTC_443 clozapine 122 µM -1.12064188248229 0.132297854486549 no 2961 0.131220164848386 4170 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3133 9127736 49.47 µM -1.1217991142927 0.132053188701674 no 2962 0.130973931454942 4230 27243420 SGTC_2872 9044037 25.97 µM -1.12228112710042 0.131951372063016 no 2963 0.130871464009899 4227 6465195 SGTC_3106 9121286 49.47 µM -1.12422174077354 0.131541999815176 no 2964 0.130459484281869 4196 15943471 SGTC_2722 naftopidil 47.16 µM -1.12460108949053 0.131462078786496 no 2965 0.130379055923278 4147 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2984 9022109 38.96 µM -1.12550362408913 0.13127206794584 no 2966 0.130187841181513 4242 6459207 SGTC_1179 1021-1431 9.29 µM -1.1255939875327 0.131253054157317 no 2967 0.130168707098227 4232 2840958 SGTC_1333 1482-0047 286 µM -1.12613165523084 0.131139960345808 no 2968 0.130054898436587 4228 3811116 SGTC_208 k072-0098 12.366 µM -1.12855170132911 0.130631757729174 no 2969 0.129543497563068 4191 5948901 SGTC_3018 9082602 49.47 µM -1.12870081880071 0.130600488092326 no 2970 0.129512031888831 4161 17332089 SGTC_1242 0402-0103 60.1 µM -1.12940661729412 0.130452553776823 no 2971 0.129363171318234 4150 432868 SGTC_2954 9074818 52.69 µM -1.13185976913454 0.129939278432803 no 2972 0.128846697410402 4251 16648742 SGTC_1898 st060199 18.6 µM -1.1340819905567 0.129475529213353 no 2973 0.128380078618432 4205 688866 SGTC_925 2064-1272 59.6 µM -1.13538067788647 0.129205041298985 no 2974 0.128107925954431 4202 6815817 SGTC_1860 st056228 74.6 µM -1.13648984678272 0.128974336236037 no 2975 0.127875806229728 4209 688679 SGTC_3105 9121040 49.47 µM -1.13694141472658 0.128880492823333 no 2976 0.127781388761298 4119 41448907 SGTC_1706 st031321 9.9705 µM -1.13701073026747 0.128866092082256 no 2977 0.127766899999386 4248 6103185 SGTC_692 k241-0027 77.8 µM -1.13958238895767 0.12833260248075 no 2978 0.127230162904223 4286 3600480 SGTC_1263 0774-1208 64.8 µM -1.14570589524257 0.127068462307072 no 2979 0.125958431882798 4280 906585 SGTC_2641 levomentholum 100 µM -1.14598497172228 0.127011056791501 no 2980 0.125900685168403 4231 16666 SGTC_226 1,3-diallylurea 8.28947 mM -1.14636227752353 0.126933474387145 no 2981 0.125822642127395 4163 74537 YKL182W FAS1 SGTC_936 3005-4620 401 µM -1.14919545273827 0.126351964797458 no 2982 0.125237697752524 4298 777207 SGTC_2889 9059656 51.95 µM -1.151263386242 0.125928694829527 no 2983 0.124811947571017 4311 3949838 SGTC_512 prima-1 270 µM -1.15177541207558 0.12582404495972 no 2984 0.124706687086074 4255 322968 A re-activator of the apoptotic function of mutant p53. SGTC_110 0850-0284 111.64 µM -1.15191935410248 0.125794636443709 no 2985 0.124677107161787 4048 3906265 SGTC_2970 9090938 41.86 µM -1.15239260038976 0.125697982208976 no 2986 0.124579890149779 4316 17217104 SGTC_804 1595-0054 20.9 µM -1.15420248747612 0.125328814951125 no 2987 0.124208581506805 4187 761523 Stimulates phospholipase C. SGTC_2395 5646831 180.19 µM -1.15769442567477 0.124618695976059 no 2988 0.123494379789761 4267 6808628 SGTC_493 zm226600 134 µM -1.15840714367634 0.124474104249221 no 2989 0.123348962641519 4279 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.1602217674397 0.124106494492243 no 2990 0.122979263352485 4307 804 An inhibitor of viral and cellular DNA polymerases. SGTC_815 1582-0027 36.9 µM -1.16087366593605 0.123974617359406 no 2991 0.122846639778989 4290 3128206 SGTC_1553 gossypol 38.6 µM -1.16533097213054 0.123075545060541 no 2992 0.121942523366613 4133 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_929 2805-0021 398 µM -1.16974115440854 0.122190485936578 no 2993 0.121052575546398 4325 3098024 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.17055565806901 0.122027517026205 no 2994 0.120888714833912 4246 688662 SGTC_2385 9074692 200 µM -1.17079328190137 0.121980001145016 no 2995 0.120840939427479 4288 17046906 SGTC_817 1391-0715 46 µM -1.17109010824485 0.121920665231811 no 2996 0.120781279741995 4237 1353946 SGTC_444 curcumin 90.4 µM -1.17391557948308 0.121356865320967 no 2997 0.120214420755526 4194 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1291 0993-0025 5.79 µM -1.17450839634783 0.121238806551616 no 2998 0.120095725408792 4260 4353356 SGTC_1647 st011722 22.4 µM -1.1763392874485 0.120874696818321 no 2999 0.119729661115166 4237 2854783 SGTC_783 0848-0141 92.7 µM -1.178369369356 0.120471874434838 no 3000 0.119324691781236 4185 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_156 3474-0145 5.642 µM -1.17863255792225 0.120419720115042 no 3001 0.119272260679257 4131 2265471 SGTC_2837 9008476 45.46 µM -1.17874333998401 0.120397771930307 no 3002 0.11925019609744 4266 2992805 SGTC_2842 9000675 19.48 µM -1.18166528425287 0.119819892195157 no 3003 0.118669269147948 4315 2989072 SGTC_2938 9059746 27.26 µM -1.18266259650944 0.11962309981696 no 3004 0.118471446757661 4266 6471769 SGTC_3310 9130229 44.1445 µM -1.18358962400677 0.119440380757069 no 3005 0.118287774857875 4297 7761258 SGTC_3154 9100113 49.47 µM -1.18526739012309 0.119110190425154 no 3006 0.117955871258051 4278 25237525 SGTC_2216 7189485 200 µM -1.18567990590612 0.119029104648119 no 3007 0.117874366446859 4276 731273 SGTC_3252 9135871 49.47 µM -1.1877219643063 0.118628283389804 no 3008 0.117471483695179 4286 17682838 SGTC_3178 9107506 49.47 µM -1.1931400320259 0.117569433953885 no 3009 0.116407267843048 4267 8897194 SGTC_2134 5324836 1.464 µM -1.19575286405224 0.117061208165182 no 3010 0.115896507538319 4228 699272 SGTC_2887 9044784 58.44 µM -1.19659870169994 0.116897017069638 no 3011 0.11573150338202 4235 6465546 SGTC_463 ikarugamyin 104 µM -1.19985738371134 0.116265978912319 no 3012 0.115097366685998 4429 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2492 derrusnin 100 µM -1.20532710627493 0.115212217333422 no 3013 0.114038524679039 4309 1715307 Part of coumarin class of compounds. SGTC_1382 3002-2117 298 µM -1.20681615718752 0.11492652580049 no 3014 0.113751476135436 4358 1497314 SGTC_1643 st009866 20.2 µM -1.2119344483668 0.113948366536221 no 3015 0.112768737138028 4248 3156273 YOR207C RET1 SGTC_1698 5-fluorocytosine 1.055 µM -1.21214441292724 0.113908367149416 no 3016 0.112728552674819 4308 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_811 0416-0114 265 µM -1.21255379056107 0.113830407264322 no 3017 0.112650232569889 4337 6612453 SGTC_396 dithiazanine 1.25 µM -1.21383799844418 0.113586095720002 no 3018 0.112404796443956 4276 10578 An antihelmenthic. SGTC_1845 st056753 3.01 µM -1.21500010626062 0.11336533528487 no 3019 0.11218302542698 4277 5375839 SGTC_2071 5230951 39.92 µM -1.21690865567782 0.11300344098066 no 3020 0.111819485992646 4343 1799272 SGTC_1609 st001574 46.4 µM -1.22158925211619 0.112119410674854 no 3021 0.110931497548065 4303 3960012 SGTC_1088 bifonazole 369 nM -1.22185156831389 0.112070013377727 no 3022 0.110881881629286 4275 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2260 7964312 200 µM -1.22667488003478 0.111164497587215 no 3023 0.109972406384202 4361 231951 SGTC_49 0717-0965 32.132 µM -1.22722396546266 0.11106174683634 no 3024 0.109869212141274 4378 5889349 YGL099W LSG1 SGTC_1459 k035-0031 35.7 µM -1.23106961225241 0.1103440142369 no 3025 0.10914841484818 4041 3877128 YMR208W ERG12 SGTC_696 1560-0013 611 µM -1.23175454275942 0.110216531910501 no 3026 0.109020394271276 4365 1650269 SGTC_1302 1159-0335 255 µM -1.23300728776043 0.109983638779313 no 3027 0.108786522597095 4333 649284 SGTC_848 0368-0089 85.6 µM -1.23463724388307 0.109681148632887 no 3028 0.108482770709906 4306 762535 SGTC_96 0929-0093 37.281 µM -1.23673786509826 0.109292193120674 no 3029 0.108092208176102 4322 6991579 SGTC_151 3013-0144 2.285 µM -1.23722287477643 0.109202528674298 no 3030 0.108002175731594 4139 906558 YHR107C CDC12 SGTC_383 2324-0395 7.37 µM -1.23765850464463 0.10912203821391 no 3031 0.107921355712381 4308 3146421 SGTC_1090 efavirenz 20.7 µM -1.23903582602509 0.108867833805115 no 3032 0.107666115395302 4334 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2429 5902844 64.44 µM -1.23917432342175 0.108842295702405 no 3033 0.107640473634521 4314 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.24040349580025 0.108615832298269 no 3034 0.107413094325165 4337 5282362 SGTC_2792 7535235 81.82 µM -1.24365282390177 0.108018806923693 no 3035 0.106813682881518 4299 1281891 SGTC_1794 st048918 76.9 µM -1.24658566375251 0.107481964587293 no 3036 0.106274730531113 4259 672303 SGTC_685 1278-0033 54.9 µM -1.24896727901232 0.107047438105447 no 3037 0.105838520978034 4405 3590572 SGTC_196 k015-0023 18.111 µM -1.25061969298609 0.106746700071721 no 3038 0.105536631143643 4280 5211998 SGTC_363 0455-0021 3.06 µM -1.25695365272079 0.105599572800426 no 3039 0.10438520937018 4289 4597466 SGTC_33 0986-0033 35.816 µM -1.25790127923623 0.105428720055662 no 3040 0.104213730504639 4298 2848082 SGTC_2757 clomiphene 4.22 µM -1.25870549192155 0.105283881090518 no 3041 0.104068363509527 4352 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_714 4296-0578 26.1 µM -1.26170357409417 0.104745194317376 no 3042 0.103527735176943 4394 1589775 SGTC_637 1181-0519 7.26 µM -1.26336984537251 0.104446667828939 no 3043 0.103228147923524 4334 6252091 YGR060W ERG25 SGTC_2296 7971656 126.45 µM -1.2736746356856 0.102614165761985 no 3044 0.10138937457542 4356 666570 SGTC_1687 st020778 55.3625 µM -1.27616086930077 0.102175559279206 no 3045 0.100949329031689 4357 4259299 SGTC_697 0508-1955 564 µM -1.27909520461811 0.101659657952765 no 3046 0.100431766044469 4344 6243113 SGTC_1409 3909-8004 61.9 µM -1.27965651178256 0.101561187996406 no 3047 0.100332982753789 4396 2119279 SGTC_1539 benzyladenosine 56 µM -1.28326896498234 0.100929117992046 no 3048 0.0996989308499851 4348 92208 A nucleotide analog. SGTC_1143 3454-2408 5.08 µM -1.28576851705555 0.100493453845173 no 3049 0.0992619303837158 4366 X1143 SGTC_2546 rhodinyl acetate 100 µM -1.28730631819755 0.100226102535559 no 3050 0.0989937711088718 4304 6708682 SGTC_1852 st056254 31.4 µM -1.2874944048592 0.100193438776162 no 3051 0.0989610092681613 4308 442583 SGTC_705 1124-0212 310 µM -1.29020340298742 0.0997238467778026 no 3052 0.0984900224665719 4343 9554485 SGTC_408 cantharidin 100 µM -1.29226714496096 0.0993671874318468 no 3053 0.0981323229034897 4324 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1288 0973-0013 65.5 µM -1.29463145996087 0.0989597297164114 no 3054 0.097723697156593 4406 4315430 SGTC_2141 5621638 7.665 µM -1.29557430524008 0.0987975844431819 no 3055 0.0975610931317478 4387 2856238 SGTC_1330 1469-0054 61.8 µM -1.29567486311527 0.0987803025404211 no 3056 0.097543762537907 4355 7102664 SGTC_3184 9108758 49.47 µM -1.29744405748427 0.0984766100932711 no 3057 0.097239220875006 4372 902885 SGTC_2358 9037157 4 µM -1.29775183440065 0.0984238482876792 no 3058 0.0971863127733307 4366 2388925 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.29791240337346 0.0983963303707274 no 3059 0.0971587187017857 4333 2724 A muscle relaxant with antifungal properties. SGTC_2566 crystal violet carbinol 226 nM -1.29846421203727 0.0983018057042844 no 3060 0.0970639332062366 4361 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_733 4069-0007 56.1 µM -1.30419761627131 0.0973236081229867 no 3061 0.0960831062163946 4383 5717425 YNL287W SEC21 SGTC_2256 7954252 200 µM -1.30845911563538 0.0966011779357512 no 3062 0.095358816522334 4372 2972920 SGTC_3067 9117431 49.47 µM -1.30856163261478 0.0965838474103094 no 3063 0.0953414422553074 4384 17150885 SGTC_1228 0124-0032 52.5 µM -1.31201705839107 0.0960010418443815 no 3064 0.0947571894924002 4419 X1228 SGTC_3195 9113082 49.47 µM -1.31681263888749 0.0951964914213702 no 3065 0.0939507176289115 4375 17018038 SGTC_2799 7812892 81.82 µM -1.32223887075752 0.0942921372861275 no 3066 0.0930443105743982 4410 20205235 SGTC_593 1203-0218 61.7 µM -1.32443742208714 0.0939275286457908 no 3067 0.092678906560393 4418 3666956 SGTC_2073 5212005 126 µM -1.32545239033375 0.0937595573873308 no 3068 0.0925105751690729 4279 691789 SGTC_1430 4049-0248 69.1 µM -1.32737276971615 0.093442352816826 no 3069 0.0921927013661822 4412 22774488 SGTC_39 0986-0283 58.349 µM -1.328290371769 0.0932910652439483 no 3070 0.0920410996253133 4447 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_339 3091-4833 71.4 µM -1.33155241525756 0.0927547083523465 no 3071 0.091503655142912 4224 3240077 SGTC_1772 st048439 82.2 µM -1.33375129128827 0.0923944501493328 no 3072 0.0911426895094018 4438 2927068 YDL195W SEC31 SGTC_1966 st070145 16.1 µM -1.33613209113656 0.0920055546119718 no 3073 0.0907530512483439 4373 3748532 SGTC_1725 st036284 20.55 µM -1.33795218573784 0.0917090668627444 no 3074 0.0904560119365491 4427 707914 SGTC_1199 1638-0010 4.46 µM -1.33923138666647 0.0915011129768048 no 3075 0.090247678798604 4375 3111136 SGTC_2374 9071832 200 µM -1.3432123874188 0.0908561760966488 no 3076 0.0896016058433932 4328 17381698 SGTC_1739 st037196 92.5 µM -1.34338092272394 0.0908289473594181 no 3077 0.0895743304823191 4425 612214 SGTC_1829 berberine 14.4 µM -1.34828089544449 0.0900399475884517 no 3078 0.0887840271969581 4367 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2481 5478948 45.16 µM -1.34936186499152 0.0898665762015565 no 3079 0.0886103817437911 4398 77792 SGTC_2119 5528445 120.635 µM -1.35012712269102 0.0897439903666081 no 3080 0.0884876048266714 4433 791935 SGTC_3316 9136639 10.545 µM -1.35159836576224 0.0895086627755157 no 3081 0.0882519167048299 4387 4903665 SGTC_1209 2323-2347 50.3 µM -1.35292545032912 0.0892967875122598 no 3082 0.088039723934867 4396 5412760 SGTC_2595 hexamethylquercetagetin 100 µM -1.35366103217116 0.0891795092716579 no 3083 0.0879222728444676 4391 386331 SGTC_1650 st011916 45.8 µM -1.35477954708307 0.0890013974141081 no 3084 0.0877439024373952 4347 242528 SGTC_526 4469-0568 170 µM -1.35563761206312 0.0888649390825331 no 3085 0.0876072492583392 4361 2901964 SGTC_1300 1094-0077 113 µM -1.35945495241087 0.0882597539174744 no 3086 0.0870012339545939 4380 5532636 SGTC_1951 sophoraflavanone G 9.2 µM -1.36085880131568 0.0880379678595382 no 3087 0.0867791576287488 4354 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1141 3253-0389 52.6 µM -1.36126911600158 0.0879732231320605 no 3088 0.0867143295829746 4396 5402031 SGTC_3186 9110464 49.47 µM -1.36225896833272 0.0878171776582005 no 3089 0.0865580859373253 4396 17018021 SGTC_1155 4088-0394 48.2 µM -1.36285900464816 0.087722685372085 no 3090 0.086463475465768 4402 2326248 SGTC_3027 9089541 49.47 µM -1.36293271349174 0.0877110831124982 no 3091 0.0864518587893036 4404 9943819 SGTC_1776 st049249 45.9 µM -1.36321122700981 0.0876672535775751 no 3092 0.0864079749788992 4434 1822314 SGTC_982 1491-0518 27.5 µM -1.36373145801997 0.087585428851132 no 3093 0.0863260497172134 4348 3091256 SGTC_3088 9117578 49.47 µM -1.36481800128406 0.0874147153230986 no 3094 0.0861551297602862 4476 678341 SGTC_617 3770-0098 35 µM -1.36537108141278 0.0873279129311849 no 3095 0.0860682241306027 4328 5962639 SGTC_3014 9081533 49.47 µM -1.36806458710305 0.086906103993318 no 3096 0.0856459301260837 4444 21367265 SGTC_2865 9030313 51.95 µM -1.36855418918131 0.0868295949843266 no 3097 0.085569336094223 4400 42562754 SGTC_2947 9072639 7.68 µM -1.37170319841226 0.086338708838612 no 3098 0.0850779261664307 4385 16488146 SGTC_1490 4089-0339 670 nM -1.37181533962082 0.0863212659528146 no 3099 0.0850604653625778 4380 742542 SGTC_360 0957-0399 1.01 µM -1.37291798380104 0.0861498966571078 no 3100 0.0848889225693039 4435 6752301 YPR165W RHO1 SGTC_200 k038-0079 37.545 µM -1.37436818962099 0.0859248981220717 no 3101 0.0846637032567768 4410 3436683 SGTC_2989 9073649 71.4286 µM -1.37527619762009 0.0857842452848821 no 3102 0.0845229164618235 4404 21367202 SGTC_2271 7849410 118.62 µM -1.37551405790188 0.0857474286011253 no 3103 0.0844860652302205 4341 972430 SGTC_569 4130-2812 160 µM -1.37618023185627 0.085644379276518 no 3104 0.0843829203473674 4277 743552 SGTC_616 4092-0450 108 µM -1.37886242112752 0.0852304140481446 no 3105 0.083968588231004 4423 787165 SGTC_1909 st060837 51.5 µM -1.37993620371757 0.0850651088743883 no 3106 0.0838031441757319 4373 678937 SGTC_917 harmaline 728.087 nM -1.38284126643673 0.0846190889102046 no 3107 0.0833567713090959 4360 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1152 3909-8331 15.9 µM -1.38809307275062 0.083817224254787 no 3108 0.0825543528504173 4401 16001939 SGTC_1658 st012944 20 µM -1.38988806883346 0.0835444705727932 no 3109 0.082281434598358 4269 24207260 SGTC_1814 st052110 31.539 µM -1.39548917763819 0.0826976571980708 no 3110 0.0814341880366313 4363 674163 SGTC_2403 6032726 181.2 µM -1.39601791565042 0.082618053898969 no 3111 0.081354550101243 4444 2881040 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.39783977345514 0.0823442087371798 no 3112 0.0810805938213394 4438 688667 SGTC_3275 9138069 49.47 µM -1.39864739819444 0.0822230327872803 no 3113 0.0809593726851803 4495 17617007 SGTC_1225 1216-0074 20.6 µM -1.40507075737744 0.0812640502745515 no 3114 0.0800001193689658 4444 4241466 SGTC_1763 st044482 94.5 µM -1.4075423169429 0.0808973125825767 no 3115 0.0796333191597353 4422 88505 SGTC_1830 st055982 50.3 µM -1.40828920559302 0.0807867331245375 no 3116 0.0795227253402899 4430 455313 An antimicrobial agent. SGTC_2972 9093619 59.92 µM -1.41393537763271 0.0799544873730987 no 3117 0.0786904386899772 4394 25236256 SGTC_2450 5739737 12.93 µM -1.41770363835949 0.079402663596544 no 3118 0.0781386537053246 4472 2262825 SGTC_281 1672-3440 14.9 µM -1.41793763321777 0.0793684927040973 no 3119 0.0781044869558539 4485 6833000 SGTC_607 4491-0986 66.8 µM -1.41914877110684 0.0791918048960254 no 3120 0.0779278238218737 4450 698981 YDR232W HEM1 SGTC_1421 4029-0249 71.4 µM -1.41914879272288 0.0791918017452125 no 3121 0.0779278206715494 4525 2894095 SGTC_1555 citronellol 128 µM -1.42416825523843 0.0784627072654395 no 3122 0.0771988859391498 4417 8842 A terpine precursor. SGTC_916 4466-0038 42 nM -1.42692705651273 0.0780641548449041 no 3123 0.0768004605394278 4509 5722064 YGL116W CDC20 SGTC_986 1493-0483 84 µM -1.43500698138708 0.0769057179362815 no 3124 0.0756425540932384 4408 40079 SGTC_747 3448-8087 38.7 µM -1.43508240451994 0.0768949662527875 no 3125 0.0756318084664501 4500 5168703 SGTC_940 3232-1287 54.8 µM -1.43696206205646 0.0766273871157983 no 3126 0.0753643868304953 4439 1585493 YIL048W NEO1 SGTC_20 0481-0013 4.944 µM -1.43757476060238 0.0765403194677341 no 3127 0.0752773732427999 4495 182045 SGTC_3034 9090421 49.47 µM -1.4381853066508 0.0764536325773841 no 3128 0.075190741550898 4372 17173761 SGTC_2301 7769476 200 µM -1.4402470782041 0.0761614489268677 no 3129 0.0748987540775591 4440 977820 SGTC_3062 9077494 49.47 µM -1.44109978059873 0.0760408570818118 no 3130 0.0747782477661596 4411 16459633 SGTC_2424 5537928 59.2 µM -1.44134609157677 0.0760060500857208 no 3131 0.0747434659554369 4471 5382802 SGTC_1329 1447-1697 50.6 µM -1.44252448026592 0.075839696012307 no 3132 0.0745772353337507 4460 2840515 SGTC_154 3389-1638 511.116 µM -1.44314780824237 0.0757518125105607 no 3133 0.0744894191119658 4441 5238686 SGTC_1718 roemerine 11.9335 µM -1.44628691296134 0.075310406278313 no 3134 0.0740483724390733 4087 235224 An aporphine alkaloid with mutagenic activity. SGTC_1508 1080-0625 72.9 µM -1.44721228236074 0.0751806600626869 no 3135 0.0739187387994635 4389 767111 SGTC_2350 9023895 38.85 µM -1.44890047722236 0.0749443971303006 no 3136 0.0736826889367564 4436 2997209 SGTC_1946 st076057 65.1 µM -1.44944419034124 0.0748684251574946 no 3137 0.0736067876978912 4450 953009 SGTC_289 k017-0060 526 µM -1.45348997107651 0.0743049600690768 no 3138 0.0730438811067149 4458 5512909 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.45567545286304 0.0740019331926277 no 3139 0.072741179405432 4475 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1871 st057448 67.3 µM -1.4570387075212 0.0738133905337981 no 3140 0.0725528478820949 4465 691747 SGTC_295 k015-0027 31 µM -1.45770888025335 0.0737208381228701 no 3141 0.0724604015956649 4534 3887424 SGTC_171 k064-0041 9.68 µM -1.45938307101513 0.0734900161143483 no 3142 0.0722298513977361 4462 53325 SGTC_2076 5212012 200 µM -1.45955581078733 0.0734662318333188 no 3143 0.0722060957049301 4450 604802 SGTC_354 2783-3500 4.88 µM -1.46936035116462 0.0721258859666164 no 3144 0.07086753772761 4459 6740761 SGTC_778 3456-2434 196 µM -1.47000979004174 0.072037769680792 no 3145 0.0707795512527499 4403 5539063 SGTC_1354 1498-1681 81 µM -1.4763353715514 0.0711838224591729 no 3146 0.0699269415034371 4483 5754243 SGTC_2458 5808907 16.39 µM -1.48121995616631 0.0705297432280358 no 3147 0.0692739850206101 4592 2731747 SGTC_1878 temozolomide 1 mM -1.48247281331204 0.0703627238381007 no 3148 0.0691072661257817 4438 5394 DNA alkylating agent. SGTC_695 3505-6186 243 µM -1.48313400673349 0.0702747022978994 no 3149 0.0690194052216821 4484 1819379 SGTC_2894 9048625 32.47 µM -1.49345339408199 0.068911880704421 no 3150 0.0676592726402104 4500 4092861 SGTC_103 0844-0104 51.839 µM -1.49554588430706 0.0686380386546737 no 3151 0.0673860171451128 4315 5375804 SGTC_979 1426-2828 121 µM -1.50044683391222 0.067999941716946 no 3152 0.0667493478071426 4567 747872 SGTC_1505 k297-0037 20.6 µM -1.50562714711361 0.067330461472902 no 3153 0.0660814577504046 4491 4089396 SGTC_2862 9027634 71.43 µM -1.50766542636466 0.0670684445908256 no 3154 0.0658200892223053 4454 5012562 SGTC_1043 0916-0009 19.3 µM -1.52199340265407 0.0652488094028541 no 3155 0.0640053668852865 4517 3101130 SGTC_1467 k284-1082 293 µM -1.52378587859432 0.0650238888811225 no 3156 0.0637811041332553 4479 3334705 SGTC_2037 5169046 200 µM -1.52497523386263 0.0648749805895304 no 3157 0.0636326375131327 4564 5718022 SGTC_3116 9124943 49.47 µM -1.53049141671587 0.0641878087317496 no 3158 0.0629475682210785 4497 41905195 YPL160W CDC60 SGTC_10 0279-0212 42.575 µM -1.5330771275513 0.0638676507696745 no 3159 0.0626284262521258 4528 39851 YBR002C RER2 SGTC_990 3985-0011 41.3 µM -1.53966792957547 0.0630572070507266 no 3160 0.0618206589867327 4480 5399565 YGL099W LSG1 SGTC_2376 9072922 81.32 µM -1.54161401639977 0.0628194428908349 no 3161 0.0615837087237496 4504 17087968 SGTC_2449 5812982 45.77 µM -1.54273313301218 0.0626830309431684 no 3162 0.0614477696517151 4449 776185 SGTC_482 fipronil 114 µM -1.54566026256996 0.0623273273134564 no 3163 0.0610933194756418 4628 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3110 9122132 49.47 µM -1.54653879554553 0.0622208760326199 no 3164 0.0609872490700011 4537 918317 SGTC_310 1273-0058 1.06 µM -1.55080657155136 0.061705768907994 no 3165 0.0604740226478694 4242 2734232 SGTC_1683 st010134 710 nM -1.55176647093305 0.0615903719877225 no 3166 0.0603590556567376 4489 3818134 SGTC_2195 6536160 144.242 µM -1.55247236134227 0.0615056190309176 no 3167 0.0602746204756067 4526 3834386 SGTC_3331 9141060 1.957 µM -1.55290033984007 0.0614542780275284 no 3168 0.0602234728034396 4465 4906567 YPR165W RHO1 SGTC_532 1548-0774 215 µM -1.55293895745386 0.0614496470421623 no 3169 0.0602188592875247 4584 5932993 SGTC_132 0417-1715 25.805 µM -1.55807409360526 0.0608362711000378 no 3170 0.0596078425286008 4494 6769098 SGTC_1757 st041620 31.8375 µM -1.56187683574972 0.0603851387809742 no 3171 0.0591585032168585 4533 5289815 SGTC_1679 SEC14.276 6.7 µM -1.56695913833997 0.0597863004453949 no 3172 0.0585621215104089 4488 1005053 YMR079W SEC14 SGTC_1791 st048313 56.1 µM -1.58026258706724 0.0582408002024115 no 3173 0.0570233719948643 4546 1204976 SGTC_3230 9131665 49.47 µM -1.5838382939806 0.0578307975003686 no 3174 0.0566152612207077 4562 15943720 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.58610732908914 0.057571801290807 no 3175 0.056357482294528 4520 688803 SGTC_2482 5981709 142.65 µM -1.58970711531376 0.0571627809320618 no 3176 0.0559504195423746 4486 877755 SGTC_2791 5663188 71.43 µM -1.59154424029492 0.0569549236478976 no 3177 0.0557435737033313 4545 54690634 SGTC_201 4262-0159 12.803 µM -1.5920689987069 0.0568956604674312 no 3178 0.05568460096255 4597 1341029 SGTC_2772 vinpocetine 57.06 µM -1.59219858273327 0.0568810334756992 no 3179 0.0556700457964786 4541 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_991 3996-0057 64.7 µM -1.59601559295836 0.0564515095425994 no 3180 0.0552426560166378 4573 715343 SGTC_1590 st077108 57.8 µM -1.59953032643263 0.0560582648781319 no 3181 0.0548514078613765 4560 5489485 SGTC_2611 pyromycin 23.93 µM -1.60049357486456 0.0559508702227636 no 3182 0.0547445655778211 4491 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2394 5221648 200 µM -1.60258862426888 0.0557178490148694 no 3183 0.0545127534568257 4567 788586 SGTC_628 1636-0253 16 µM -1.60861329323278 0.0550520232965011 no 3184 0.0538504628472056 4543 4456143 SGTC_3109 9122853 49.47 µM -1.61013866128106 0.0548844461367725 no 3185 0.0536837942978333 4571 1234709 SGTC_1060 3448-7350 82 µM -1.61240290204234 0.0546364399865012 no 3186 0.0534371468898258 4499 570178 SGTC_3264 9137442 49.47 µM -1.61327767567659 0.054540862170994 no 3187 0.053342097203546 4524 17015726 SGTC_706 4262-0057 46.9 µM -1.61391497925174 0.0544713136401587 no 3188 0.0532729345483562 4539 883298 SGTC_1652 st011932 78 µM -1.61545224267645 0.0543038417244315 no 3189 0.0531063972728916 4489 1551076 SGTC_1310 1188-0297 994 nM -1.61657330465415 0.0541819685156611 no 3190 0.0529852090839068 4438 1588352 SGTC_3047 9092122 49.47 µM -1.61984107898578 0.0538279560195349 no 3191 0.0526332097339943 4541 17173831 SGTC_2884 9058502 51.95 µM -1.62069385152561 0.05373587339163 no 3192 0.0525416564593457 4528 6471554 SGTC_2648 atorvastatin 78.68 µM -1.62072011396187 0.0537330395475439 no 3193 0.0525388389436324 4543 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1686 st019653 115.5 µM -1.62405854025514 0.0533737699707357 no 3194 0.0521816576544844 4548 97252 SGTC_355 1311-2252 105 µM -1.62711629903101 0.0530463776924167 no 3195 0.0518561999940728 4522 5338538 SGTC_958 1222-0007 33 µM -1.63232866745449 0.0524919658033185 no 3196 0.0513051336114486 4601 7312461 SGTC_544 k015-0020 52.4 µM -1.63254082553591 0.052469497466244 no 3197 0.0512828027077986 4591 3008304 SGTC_1715 st032160 10.2275 µM -1.63553764701166 0.0521529376920171 no 3198 0.0509681946897451 4463 5289825 SGTC_712 r015-0009 80.6 µM -1.63812493675143 0.0518808593745772 no 3199 0.050697817016771 4592 6813872 YLR060W FRS1 SGTC_497 capsazepine 133 µM -1.64111615471573 0.0515677113160981 no 3200 0.0503866529687847 4512 2733484 A calcium channel blocker. SGTC_2952 9073731 13.78 µM -1.64741458444612 0.0509132487168398 no 3201 0.0497364298185082 4550 16457353 SGTC_586 0957-0265 8.15 µM -1.64849787758825 0.0508013543162462 no 3202 0.0496252729351091 4485 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1514 1189-1591 158 µM -1.65910058487107 0.0497164987181534 no 3203 0.0485477627260156 4578 767698 YMR146C TIF34 SGTC_127 0180-0333 59.125 µM -1.67501974343688 0.0481224669854911 no 3204 0.0469651789989219 4489 771601 SGTC_1216 1165-0504 9.65 µM -1.67864101021097 0.0477656303704411 no 3205 0.0466110144680547 4616 6304004 SGTC_1928 4'-methoxychalcone 40.3 µM -1.68178075893198 0.0474579598486406 no 3206 0.0463056805601261 4576 641818 SGTC_2617 dihydrotanshinone i 20.83 µM -1.68330656938805 0.0473090168552884 no 3207 0.0461578796674904 4522 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_57 miconazole 162.5 nM -1.68557164806145 0.0470886008011272 no 3208 0.0459391669501333 4423 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1204 4049-0315 18.3 µM -1.68578155398483 0.0470682164937084 no 3209 0.0459189409661213 4587 588402 SGTC_1492 4158-0558 28.5 µM -1.68814054068279 0.0468396176494331 no 3210 0.0456921269095591 4602 3967268 SGTC_220 paclitaxel 373.376 µM -1.68820091052852 0.0468337791854399 no 3211 0.0456863342529989 4557 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2158 5657123 3.6195 µM -1.6884481781781 0.0468098716287321 no 3212 0.0456626143866526 4586 2858827 SGTC_1431 4049-0260 9.09 µM -1.68857969126839 0.0467971600168137 no 3213 0.0456500026456352 4615 3854841 SGTC_3130 9127414 49.47 µM -1.68911011722107 0.0467459189366896 no 3214 0.0455991646865688 4623 1494646 SGTC_2926 9010726 65.15 µM -1.69132337012947 0.0465325962048899 no 3215 0.0453875294644944 4566 2994293 SGTC_3132 9126706 49.47 µM -1.69313588423654 0.0463584808993726 no 3216 0.0452148026332764 4593 850858 SGTC_1260 0700-1617 7.75 µM -1.69925446749105 0.0457745722228351 no 3217 0.0446356238485425 4559 2853078 SGTC_1793 st048256 72.231 µM -1.70064249776757 0.0456429357296062 no 3218 0.0445050694286395 4583 672022 SGTC_255 tunicamycin 200.472 nM -1.70243103524983 0.0454737652727023 no 3219 0.0443372981606988 4507 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1525 8-methoxypsoralen 92.5 µM -1.70375874687331 0.0453485088306137 no 3220 0.0442130839404289 4606 4114 Related to psoralen; DNA damaging agent. SGTC_1215 3852-0577 11.2 µM -1.7041778645709 0.0453090269055796 no 3221 0.0441739316365214 4607 2884876 SGTC_1303 1160-0052 261 µM -1.70726489353154 0.0450190723474685 no 3222 0.0438864140814579 4552 3562476 SGTC_3294 9122953 26.2835 µM -1.7091646295693 0.0448413799190241 no 3223 0.043710229333739 4564 16459826 SGTC_1498 4478-3555 97.6 µM -1.71406237256995 0.0443858716516272 no 3224 0.0432586356829588 4615 3437919 SGTC_769 0302-0231 76 µM -1.71835418631557 0.0439897890603228 no 3225 0.042866015677169 4519 571869 YER009W NTF2 SGTC_2724 maprotiline 69.64 µM -1.71931209183654 0.0439017761803503 no 3226 0.04277877968382 4520 4011 A tricyclic antidepressant. SGTC_509 pifithrin 175 µM -1.71976282292025 0.0438604119299621 no 3227 0.0427377814968842 4674 4817 A p53 inhibitor. SGTC_1994 st072947 40.9 µM -1.72095843429281 0.0437508412077906 no 3228 0.0426291833678117 4640 5286565 YDL195W SEC31 SGTC_3268 9137683 49.47 µM -1.72327240098229 0.043539407177284 no 3229 0.0424196381271464 4649 1953228 SGTC_1685 st024049 53.0905 µM -1.72557882702467 0.0433294836097692 no 3230 0.0422116055906871 4619 1941139 SGTC_2231 micatex 6.853 µM -1.75628356135995 0.0406119440098328 no 3231 0.0395200013669823 4629 20737 An antifungal of unknown mechanism. SGTC_1059 3448-6867 171 µM -1.76286145086878 0.0400481426750295 no 3232 0.0389619300440193 4578 3934407 SGTC_2428 5615643 7.78 µM -1.76375796883928 0.0399717955488123 no 3233 0.0388863683615528 4605 2253075 SGTC_1389 3405-0187 19 µM -1.76783334113745 0.0396262280409611 no 3234 0.0385443846297985 4598 799890 SGTC_715 0868-0130 184 µM -1.77328749263953 0.0391675538031941 no 3235 0.0380905402519499 4668 2876258 SGTC_1820 st053765 18.6 µM -1.77540826154912 0.0389903757681569 no 3236 0.0379152504404225 4648 3690829 SGTC_1653 st012112 65 µM -1.77593465543993 0.0389464998291 no 3237 0.0378718440488401 4594 720429 SGTC_1385 3091-4834 14.1 µM -1.7782893892284 0.038750720197371 no 3238 0.0376781690763452 4607 4072814 SGTC_3141 9094609 49.47 µM -1.78309765769794 0.0383534361833843 no 3239 0.0372852038369798 4563 25236309 YDL196W YDL196W SGTC_2275 7947463 200 µM -1.78425679872268 0.0382581603594915 no 3240 0.037190973340068 4584 1225414 SGTC_1370 2001-0092 44.6 µM -1.79493830474017 0.037389244877273 no 3241 0.0363317650649687 4591 790957 SGTC_3272 9137413 49.47 µM -1.79657124741771 0.0372578404494423 no 3242 0.0362018562090981 4572 17614870 SGTC_260 nsc-65238 3.989 µM -1.79695192372258 0.0372272613659213 no 3243 0.0361716262092716 4622 3246252 SGTC_1811 st050069 61.5 µM -1.8009181577455 0.0369098787673815 no 3244 0.035857890291215 4620 3877702 SGTC_245 methotrexate 289.6 µM -1.80898480233946 0.0362712010630979 no 3245 0.0352266822222618 4587 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_534 k292-0788 63.4 µM -1.81466457563794 0.0358269542672844 no 3246 0.0347877360540135 4668 4146317 SGTC_1740 st038286 13.222 µM -1.81726758724016 0.0356248531473904 no 3247 0.0345880752247544 4624 716786 SGTC_2185 6113692 200 µM -1.83059420882087 0.0346047468692868 no 3248 0.0335805667957506 4625 874150 SGTC_1257 0669-0121 16 µM -1.83064885289679 0.0346006139769861 no 3249 0.0335764859074688 4627 4307855 SGTC_1939 st074455 53.6 µM -1.84632790681679 0.0334313998289046 no 3250 0.0324223040319951 4590 1644229 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.8467697697934 0.0333989265378729 no 3251 0.0323902574668262 4652 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3026 9090633 49.47 µM -1.8498701443446 0.033171804289099 no 3252 0.0321661339512192 4649 25236842 SGTC_540 1187-0821 17.3 µM -1.85912980578929 0.0325010386559366 no 3253 0.031504370698312 4584 847520 SGTC_3352 9151559 45.5865 µM -1.86043141937532 0.0324076535678067 no 3254 0.0314122564468134 4637 17159339 SGTC_2769 toremifene 3.73 µM -1.86213452589906 0.0322857975782915 no 3255 0.0312920652427559 4635 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_921 1561-0023 372 µM -1.86772086854013 0.0318887506319297 no 3256 0.0309004941401372 4621 24050882 SGTC_760 0568-0725 82.9 µM -1.89259493435617 0.0301694922087564 no 3257 0.0292058789720378 4654 3916171 SGTC_1080 nisoldipine 24.4 µM -1.89461269608341 0.0300334627999165 no 3258 0.0290718657695453 4686 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1277 0873-0036 22 µM -1.8995824817096 0.029700587526771 no 3259 0.0287439664872234 4689 5965735 SGTC_2805 7950783 58.44 µM -1.90553276306424 0.0293060716560603 no 3260 0.0283554263949175 4646 1178958 YDL195W SEC31 SGTC_23 0213-0011 39.996 µM -1.91253523960095 0.028847377477964 no 3261 0.0279037885561935 4646 627608 SGTC_1906 st060206 94.7 µM -1.91991728481672 0.0283702980798622 no 3262 0.0274341741252276 4668 5133468 SGTC_1426 4048-4480 71.7 µM -1.91995855995894 0.0283676491625177 no 3263 0.0274315670184572 4681 14224343 SGTC_1392 3455-1037 33.9 µM -1.92000011311192 0.0283649826111617 no 3264 0.0274289425600779 4673 981132 SGTC_2106 5357045 167.29 µM -1.92517789760031 0.0280343420582789 no 3265 0.0271035531090339 4674 668842 SGTC_3073 9114972 49.47 µM -1.92715567584696 0.0279088960453437 no 3266 0.0269801159664739 4669 41905075 SGTC_757 1066-0008 322 µM -1.93227708305396 0.0275862283038701 no 3267 0.0266626577156003 4663 6842497 SGTC_1999 st074831 12.5 µM -1.93303666801373 0.0275386374704471 no 3268 0.0266158404334338 4648 17112523 SGTC_1503 4585-0012 61.3 µM -1.93673609237235 0.0273078321159974 no 3269 0.0263888057293879 4686 2922052 SGTC_1809 st050081 57.6 µM -1.93743414243335 0.0272644625481944 no 3270 0.0263461482354002 4696 5036894 SGTC_1893 st059353 36.1 µM -1.94238758774995 0.0269583546247163 no 3271 0.0260450983911415 4661 3112488 SGTC_2702 st077768 96.8 µM -1.94980952537101 0.026505074569203 no 3272 0.0255994129094366 4646 6484119 SGTC_163 TUB2.036 7.546 µM -1.95040426049094 0.0264690295462742 no 3273 0.0255639772305399 4613 15992207 YJR013W GPI14 SGTC_2165 5727197 32.143 µM -1.95498116475382 0.026193006098229 no 3274 0.0252926467317517 4666 1361712 SGTC_1985 st071382 65.5 µM -1.95699376437937 0.026072394526697 no 3275 0.0251741007431911 4680 6123237 SGTC_1436 4092-1007 8.32 µM -1.98305691642999 0.0245519907510688 no 3276 0.0236805361577103 4689 2881121 SGTC_643 k048-0106 28.4 µM -1.98342513429448 0.024531055381631 no 3277 0.0236599809610653 4709 6763920 SGTC_464 bw-b 70c 158 µM -1.99032881586197 0.0241413055570383 no 3278 0.0232773628578344 4671 5353454 SGTC_568 1193-0097 7.48 µM -1.9911978621986 0.0240926138661148 no 3279 0.0232295694045441 4493 3646150 SGTC_2749 bexarotene 57.39 µM -1.99794102614599 0.0237175986937544 no 3280 0.0228615270601642 4666 82146 An retinoic acid receptor inhibitor. SGTC_533 1222-0222 6.71 µM -2.00008158230655 0.0235995847315256 no 3281 0.02274572759993 4709 3982874 SGTC_1744 st037937 38.9 µM -2.00899533138785 0.0231134457026187 no 3282 0.0222688144252676 4688 1016152 SGTC_1427 4048-4900 550 nM -2.01031627107071 0.0230421265555325 no 3283 0.0221988629276106 4690 24132586 SGTC_2626 ethyl orsellinate 100 µM -2.02605286500097 0.0222066499546574 no 3284 0.0213796837773885 4635 75653 A natural product. SGTC_1276 0871-0068 94.2 µM -2.02780661417477 0.0221151443306321 no 3285 0.0212899945253357 4692 3414906 SGTC_2698 st077697 67.5 µM -2.03976342039738 0.0214997159580253 no 3286 0.0206869473944368 4658 3154499 SGTC_1008 4106-0037 6 µM -2.04512338700734 0.0212285684589251 no 3287 0.0204213475693023 4713 2905394 SGTC_1948 st076329 66.6 µM -2.04980559946613 0.020994079143008 no 3288 0.0201917024903812 4634 24208413 SGTC_2328 6201408 200 µM -2.06236829657533 0.02037573386847 no 3289 0.0195863426394086 4646 2890418 SGTC_1123 mangostin 811.285 nM -2.06495628728664 0.0202502870507391 no 3290 0.0194635682528912 4695 5281650 An antioxidant. SGTC_2765 myclobutanil 7.74 µM -2.06723193490887 0.0201405219566805 no 3291 0.0193561521940951 4688 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_874 0599-0792 117 µM -2.07576447465852 0.0197334397258274 no 3292 0.0189578697613982 4692 765305 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -2.08321775883958 0.0193835842516038 no 3293 0.018615689542922 4706 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1058 3448-5425 97.3 µM -2.0897646929854 0.0190806340213402 no 3294 0.0183194712117905 4671 7279705 SGTC_3213 9129884 49.47 µM -2.10096403887794 0.0185717331357448 no 3295 0.0178220615648388 4659 17190742 SGTC_2094 5332512 191.667 µM -2.10455600305692 0.0184109805890638 no 3296 0.0176649874268691 4717 755774 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.1111937885555 0.0181170348395347 no 3297 0.0173778292573574 4717 7104 SGTC_764 1951-2361 146 µM -2.1209102519784 0.0176939726815615 no 3298 0.016964677880151 4716 5438930 SGTC_1604 st002052 72.4 µM -2.12263324541353 0.017619839043272 no 3299 0.016892298413486 4734 6254834 YHR062C RPP1 SGTC_2317 5986382 200 µM -2.13712016975724 0.0170069431291705 no 3300 0.0162941094192363 4709 877883 SGTC_2964 9083345 53.42 µM -2.13887604667732 0.0169339107712786 no 3301 0.0162228542297895 4684 17741579 SGTC_147 4466-0538 29.23 µM -2.14351796490834 0.0167421292923736 no 3302 0.0160357650598072 4697 6742687 YHR072W ERG7 SGTC_410 α-linolenic acid 100 µM -2.15109528555632 0.0164330634306213 no 3303 0.0157343397751109 4730 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_539 4859-0462 2.54 µM -2.15254567069856 0.0163744650731404 no 3304 0.0156772011396762 4701 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_762 1165-0429 115 µM -2.16822646542998 0.0157522721619479 no 3305 0.0150707300657842 4721 5967793 SGTC_561 1550-0330 72.9 µM -2.18689102676303 0.015038221891291 no 3306 0.0143752400746759 4714 6812934 SGTC_2054 5233173 129 µM -2.20580975296302 0.0143430162753324 no 3307 0.0136986615675446 4723 6889 SGTC_3274 9138298 49.47 µM -2.22908275398257 0.0135259204926368 no 3308 0.012904199586105 4708 17015756 SGTC_2100 5377183 190 µM -2.24326026373155 0.0130481136235029 no 3309 0.0124400180908184 4745 2844202 SGTC_758 0868-0029 16 µM -2.2563393162601 0.0126203358106904 no 3310 0.0120246944582331 4655 762687 SGTC_1424 4048-1941 275 µM -2.27626151482782 0.0119920750588899 no 3311 0.0114151810347054 4770 X1424 SGTC_761 k216-0224 480 µM -2.28404350659166 0.01175413387222 no 3312 0.0111844870890463 4739 1340404 SGTC_393 acivicin 6.25 µM -2.28923839915943 0.0115975855421522 no 3313 0.0110327523252619 4643 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_495 decylubiquinone 155 µM -2.32799472831288 0.0104857523876458 no 3314 0.0099561917971863 4744 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1819 st053448 58.6 µM -2.32927717684976 0.0104506065836057 no 3315 0.00992219332733979 4730 2857616 SGTC_1213 1315-0166 115 µM -2.33872095870712 0.0101949446114398 no 3316 0.00967493986615038 4725 768401 SGTC_3042 9091578 49.47 µM -2.34558568502648 0.0100125432764529 no 3317 0.00949860574089312 4743 25236497 SGTC_3337 9144342 33.5465 µM -2.38034240229183 0.00913209364502769 no 3318 0.00864827893489983 4738 17682949 SGTC_1907 st060210 83.7 µM -2.39044667591247 0.00888919493320579 no 3319 0.00841394630321892 4741 688793 SGTC_3218 9131285 49.47 µM -2.3941087475589 0.00880256979084118 no 3320 0.00833040408840275 4711 17156417 SGTC_104 0074-0074 590.992 µM -2.43197549275103 0.00794933650427427 no 3321 0.00750836166843159 4729 3943124 SGTC_2294 7971431 200 µM -2.43871093656598 0.00780543677780208 no 3322 0.00736987674213434 4742 5741572 SGTC_2819 7996655 46.38 µM -2.44031963808681 0.00777140855370777 no 3323 0.00733713577190378 4737 6456960 SGTC_2217 6934799 96.0675 µM -2.45713783210832 0.00742340214326586 no 3324 0.00700244712196305 4761 675606 SGTC_2117 5521686 200 µM -2.47462266213677 0.00707623253774925 no 3325 0.00666885054332925 4763 803312 SGTC_3328 9140624 29.0385 µM -2.50563736617602 0.00649554259243695 no 3326 0.00611154544518307 4753 4904392 SGTC_521 r062-0005 13.8 µM -2.51240111935789 0.00637465077159373 no 3327 0.00599563521666419 4733 2832033 SGTC_3266 9136860 49.47 µM -2.53214002528027 0.00603315633833009 no 3328 0.00566843542218175 4579 4871271 YPR165W RHO1 SGTC_116 0155-0182 31.788 µM -2.5385201968467 0.00592629701671275 no 3329 0.00556611886038041 4696 771486 SGTC_2701 st077767 14.721 µM -2.54690608726738 0.00578839896462008 no 3330 0.0054341338603086 4751 5721188 SGTC_2336 9001819 198.65 µM -2.5499366052744 0.00573926982746359 no 3331 0.00538712544035643 4737 2989602 SGTC_1648 st011736 69.8 µM -2.59928942582242 0.00498966422962937 no 3332 0.00467084865132089 4776 2855514 SGTC_474 dl-dihydrosphingosine 5 µM -2.6553529576829 0.00424497662800505 no 3333 0.00396127324640697 4770 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1032 k061-1018 98.7 µM -2.67504165041689 0.00400805702928593 no 3334 0.00373599833511612 4785 4005393 SGTC_3340 9146634 11.102 µM -2.68775014916007 0.00386148958343717 no 3335 0.0035967599624397 4772 4907387 SGTC_2969 9091408 28.7 µM -2.71199839428064 0.00359509510562279 no 3336 0.00334394583978696 4733 4286311 SGTC_1929 genistein trimethyl ether 50.5 µM -2.74308011597934 0.00327779837153201 no 3337 0.00304329167416602 4773 136420 SGTC_37 0566-0070 1.56 µM -2.7438987612031 0.00326979278393669 no 3338 0.00303571294668547 4756 1626686 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.77253332833241 0.00300060586972871 no 3339 0.00278109116685452 4759 521171 SGTC_553 k007-0256 45.7 µM -2.84404675783585 0.00241338746063416 no 3340 0.00222722552514775 4793 6287000 SGTC_2303 7774051 200 µM -2.84734654012563 0.00238899125719179 no 3341 0.00220426717409631 4773 2953184 SGTC_193 1273-0060 1.558 µM -2.85055971036955 0.00236545009655361 no 3342 0.00218211776282476 4745 2847393 YHR072W ERG7 SGTC_1851 st056236 18.9 µM -2.85217437189381 0.00235369979138327 no 3343 0.00217106372394208 4772 5393171 SGTC_3030 9087619 49.47 µM -2.91275636625367 0.00194925018579374 no 3344 0.00179126996594834 4780 25236973 SGTC_3145 9085516 49.47 µM -3.00329213461714 0.00146154563156247 no 3345 0.00133537962916264 4775 25236195 SGTC_2549 cedrol 20.94 µM -3.02712870737532 0.00135316616992342 no 3346 0.00123444405607763 4783 6708665 A sedative which affects the nervous system. SGTC_229 benomyl 22.8748 µM -3.15056797384005 0.000900501055952844 yes 3347 0.000814766666109057 4807 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3209 9113616 49.47 µM -3.18524243200044 0.000801158309906486 yes 3348 0.000723163944559704 4787 16649353 SGTC_3326 9140064 16.379 µM -3.30025859631816 0.000539404502795716 yes 3349 0.00048297888241561 4791 1868434 SGTC_1243 0416-0003 5.65 µM -3.44643274404757 0.000320613205428491 yes 3350 0.000284019969294711 4788 2141977 SGTC_2822 7994718 71.43 µM -3.54629439263911 0.000222193852612593 yes 3351 0.000195344742237575 4798 1018011 SGTC_1859 st055998 20 µM -3.93737938146483 4.83713032978288e-05 yes 3352 4.11881577006828e-05 4797 676301 SGTC_2001 4023502 57.655 µM -4.06023138462679 2.90989157569574e-05 yes 3353 2.45120542703565e-05 4804 108941 YCR052W RSC6 SGTC_1927 st060202 13.8 µM -4.18709963159479 1.69646738883277e-05 yes 3354 1.41270909506667e-05 4809 688887 SGTC_2817 7995342 71.43 µM -4.2890712119726 1.08760728878571e-05 yes 3355 8.97109218406313e-06 4805 18879975 SGTC_1786 berberine 21.6 µM -4.54466189888409 3.41957732396521e-06 yes 3356 2.7511751004945e-06 4795 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.