SGTCid condition conc unit NET1|YJL076W.score NET1|YJL076W.strain.pval NET1|YJL076W.strain.significant NET1|YJL076W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2988 9073640 71.4286 µM 6.18780040380481 4.27704400246519e-10 yes 1 3.05047539353376e-10 3 9102229
SGTC_1516 st013856 110 µM 6.08706521285753 7.99422448784211e-10 yes 2 5.74995693283442e-10 1 5281404 A mutagen and neurotoxin.
SGTC_542 3381-0244 89.3 µM 5.71623673276973 7.34591354976331e-09 yes 3 5.44544938921727e-09 6 1112843
SGTC_1014 4130-3005 69.3 µM 4.57315294866364 2.97927886897977e-06 yes 4 2.40219580847548e-06 3 743608
SGTC_638 3970-0837 4.09 µM 4.48506198509672 4.49352253033935e-06 yes 5 3.64463705935351e-06 2 4118451 YLR208W SEC13
SGTC_3189 9110682 49.47 µM 4.4312613716023 5.75457217783852e-06 yes 6 4.68417247840047e-06 7 17122418
SGTC_1766 st045414 44.774 µM 4.3089112866843 9.99703786494364e-06 yes 7 8.20300772201587e-06 10 253960
SGTC_2458 5808907 16.39 µM 4.09075415672322 2.58385621349812e-05 yes 8 2.14986363613796e-05 3 2731747
SGTC_1346 1488-2224 62.4 µM 4.06043712383455 2.93786599552519e-05 yes 9 2.44904634329608e-05 10 3722427
SGTC_2846 9008642 19.48 µM 3.95831403875687 4.49884420063422e-05 yes 10 3.77403372612211e-05 6 2992898
SGTC_2401 5128683 200 µM 3.8188446150913 7.92424547323496e-05 yes 11 6.70390905844094e-05 9 708373
SGTC_3078 9116413 49.47 µM 3.8079069601306 8.27757137775091e-05 yes 12 7.00739898006721e-05 6 17177322
SGTC_1090 efavirenz 20.7 µM 3.8024345645969 8.45986251220612e-05 yes 13 7.16405586173956e-05 4 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_66 0109-0187 42.4 µM 3.78529541452153 9.05552180777583e-05 yes 14 7.67630463851274e-05 6 759417
SGTC_2488 5268135 45.7 µM 3.74722596368822 0.000105225714630097 yes 15 8.94005023278124e-05 9 1270356 YLR208W SEC13
SGTC_599 1935-0052 86.5 µM 3.74707604129657 0.000105287670145167 yes 16 8.94539318910522e-05 5 9557311
SGTC_285 1486-1325 46 µM 3.74349290871729 0.000106778635148066 yes 17 9.07398632583312e-05 6 22310230
SGTC_1650 st011916 45.8 µM 3.67870201249204 0.000137406646615914 yes 18 0.000117211985490489 3 242528
SGTC_594 1487-1584 10.8 µM 3.67557010529368 0.000139078075834818 yes 19 0.000118659429448029 12 5013332
SGTC_695 3505-6186 243 µM 3.65116192979256 0.000152772281081012 yes 20 0.000130528286049014 9 1819379
SGTC_1324 1418-0026 34.4 µM 3.63856499759939 0.000160324242130663 yes 21 0.000137080719125807 5 1372513
SGTC_683 panaxydol 45 µM 3.60976791228533 0.000178920514900892 yes 22 0.000153235546439854 2 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_453 enantio-paf c16 10 µM 3.59211929948686 0.000191294825056664 yes 23 0.000163999810917971 25 13871343 A lipid and platelet activating factor
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.59043940474619 0.000192513466964372 yes 24 0.000165060486014949 4 688664
SGTC_2311 7694451 200 µM 3.55051723803118 0.000223699292917783 yes 25 0.000192237478202808 16 2163142
SGTC_129 0088-0017 176.636 µM 3.48535672719209 0.00028490559450402 yes 26 0.00024574067146782 8 182446
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.47453837098604 0.000296464917388758 yes 27 0.000255866584563279 18 1377
SGTC_885 0865-0106 16.8 µM 3.46846606144673 0.000303142938398756 yes 28 0.000261719318683209 19 2793380
SGTC_359 0081-0058 15.9 µM 3.463379734253 0.000308844089395558 yes 29 0.000266717498687339 19 3494159
SGTC_1135 dihydrocapsaicin 536.708 nM 3.46254141274304 0.000309793267390733 yes 30 0.000267549780242476 8 107982 A Capsaicinoid.
SGTC_2312 7706453 155.7 µM 3.39299100715602 0.000398700274109295 yes 31 0.000345669539123138 19 976098
SGTC_2507 purpurin 79.67 µM 3.38083871841823 0.000416477455855429 yes 32 0.00036132473016587 10 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2482 5981709 142.65 µM 3.33910059136678 0.000483287695738522 yes 33 0.000420250612539339 21 877755
SGTC_2236 dapsone 200 µM 3.26094989254786 0.000635771766274543 yes 34 0.000555198303430619 3 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1616 st002734 56.1 µM 3.25925568333926 0.000639522521774221 yes 35 0.000558524730885394 14 4026101
SGTC_1389 3405-0187 19 µM 3.22916715366036 0.000709630656762951 yes 36 0.000620756533147383 11 799890
SGTC_682 0kpi-0099 17 µM 3.21946832052937 0.00073369766480526 yes 37 0.00064214275168926 55 1714895 YML126C ERG13
SGTC_909 3448-9333 149 µM 3.21375349191771 0.000748228546858811 yes 38 0.000655060483301753 5 3344074
SGTC_371 0195-0006 7.36 µM 3.18536044662642 0.000824433330750047 yes 39 0.000722869069220766 20 3928593
SGTC_2495 cafestol 54.53 µM 3.16672298550345 0.000878270656911549 yes 40 0.000770835497900476 18 16667697 An anti-infammatory.
SGTC_974 1326-0144 138 µM 3.16362070889404 0.000887539721470691 yes 41 0.000779098600902569 17 5411856
SGTC_3140 9094243 49.47 µM 3.13755893644654 0.000969032712187402 yes 42 0.000851805102420629 12 19291112
SGTC_1127 asiatic acid 681.4 nM 3.10928965338302 0.00106515476930879 no 43 0.000937688833262221 12 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2877 9040724 71.43 µM 3.04818528731259 0.0013034729354771 no 44 0.00115113961919318 9 6463895
SGTC_2840 9008771 71.43 µM 3.00541302201387 0.00149828792317643 no 45 0.00132610218934412 3 2992978
SGTC_1822 st052468 42 µM 2.99745602531117 0.00153733444401176 no 46 0.00136121566234553 4 2873678
SGTC_455 paf C-16 10 µM 2.9960015610187 0.00154457129838411 no 47 0.00136772516703182 14 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1847 st056231 15 µM 2.97963334390638 0.00162818221872569 no 48 0.00144296796144534 16 5393180
SGTC_1214 0358-0031 63.7 µM 2.97565312687139 0.00164912732027967 no 49 0.00146182674297107 16 4301366
SGTC_1583 clindamycin 39.6 µM 2.92298868274857 0.00195034090971568 no 50 0.00173344558593631 24 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_893 0958-0369 48.9 µM 2.92026887540988 0.00196717564528439 no 51 0.00174864752141062 14 6819948
SGTC_1055 3448-0672 86 µM 2.91884762823824 0.00197602510900583 no 52 0.00175663952876965 32 748378
SGTC_2012 4023501 200 µM 2.89545041415349 0.00212700028456336 no 53 0.00189307420589623 24 3477460
SGTC_1941 st076221 61.8 µM 2.88136482637071 0.00222286058933242 no 54 0.00197978516583684 26 2828568
SGTC_936 3005-4620 401 µM 2.86981026607243 0.00230440044888086 no 55 0.00205359083181614 12 777207
SGTC_2008 4012253 172 µM 2.84972730303172 0.00245259362833393 no 56 0.00218783636601351 23 603940
SGTC_2328 6201408 200 µM 2.81960076033436 0.00269109953612601 no 57 0.00240417161599078 27 2890418
SGTC_1009 4106-0057 9.87 µM 2.77135495882443 0.00311691613009442 no 58 0.00279117679722254 26 2928005
SGTC_852 0418-0143 439 µM 2.77067967740882 0.00312328417293564 no 59 0.00279697137503891 31 5369229
SGTC_2855 9016525 58.44 µM 2.75483301575192 0.00327612353271653 no 60 0.00293610484475896 19 43811474
SGTC_1430 4049-0248 69.1 µM 2.74036407546129 0.00342151464179422 no 61 0.00306855803378704 9 22774488
SGTC_1488 4013-0813 75.9 µM 2.73929779895059 0.00343245509016423 no 62 0.00307852875535012 8 2910057
SGTC_914 3820-6779 408 µM 2.73428136014888 0.0034843488011124 no 63 0.00312582993473193 14 2893481
SGTC_339 3091-4833 71.4 µM 2.70762141153794 0.00377214418682051 no 64 0.0033883639187157 46 3240077
SGTC_1617 st002906 78 µM 2.68707605293095 0.00400828378158217 no 65 0.00360402693569011 16 5150859
SGTC_2938 9059746 27.26 µM 2.67301710153151 0.00417741234939984 no 66 0.00375862090663103 29 6471769
SGTC_1919 st067113 52.3 µM 2.6564869917965 0.00438441347332791 no 67 0.00394797485738853 26 1268243
SGTC_1366 1683-0113 21.9 µM 2.64375333363564 0.00455007218973405 no 68 0.00409961917092326 15 708623
SGTC_3013 9080133 71.4286 µM 2.63579641144372 0.00465640326967651 no 69 0.004197003866376 14 17050193
SGTC_3058 9093861 49.47 µM 2.62009894230323 0.00487269620799665 no 70 0.00439521293679158 20 17217477
SGTC_1010 4112-3296 15.2 µM 2.59874712229627 0.00518126062571597 no 71 0.00467823356626775 26 704384
SGTC_2597 laccaic acid a 100 µM 2.58255465717877 0.00542673562547643 no 72 0.00490359131695847 33 5491415 A textile dye.
SGTC_2923 7992654 58.14 µM 2.5676561363098 0.00566166970946652 no 73 0.00511943336049107 25 2985126
SGTC_3128 9127691 49.47 µM 2.56373164605013 0.00572503856824418 no 74 0.00517767870865848 18 41316314
SGTC_1311 1190-0148 100 µM 2.54301972526016 0.00607001477602885 no 75 0.00549495124002634 32 1961333
SGTC_1673 st016611 27.3 µM 2.51926284536504 0.00648828595766129 no 76 0.0058800415770737 29 5226799
SGTC_1387 3342-1166 1.8 µM 2.51867136857858 0.00649901725973799 no 77 0.00588992724811538 13 3418228
SGTC_690 glyoxal 20.3 µM 2.50845671115863 0.0066868369910353 no 78 0.00606299124752587 59 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2112 5488546 200 µM 2.47825387041726 0.00727054327700063 no 79 0.0066013583609269 33 600757
SGTC_865 0488-0499 301 µM 2.46836539770266 0.00747118025827352 no 80 0.00678658442148287 20 9634651
SGTC_504 lovastatin 124 µM 2.46439032211914 0.00755319911786237 no 81 0.00686232802365673 31 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1017 4239-0030 168 µM 2.46295930823305 0.00758291917285623 no 82 0.00688977767826153 19 1149593
SGTC_482 fipronil 114 µM 2.43664071805645 0.00814818082848864 no 83 0.00741220013985274 8 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1765 st044815 90.4 µM 2.42876712481126 0.0083243314317018 no 84 0.00757512999926871 42 645695
SGTC_1602 st001878 87.6 µM 2.42785774816534 0.00834489016523466 no 85 0.00759414960544671 47 595405 YLR310C CDC25
SGTC_1104 tacrolimus 29.8 µM 2.40931111129065 0.00877401992453671 no 86 0.00799133350616429 38 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1987 st072290 61.9 µM 2.38891681169223 0.0092681195858342 no 87 0.00844906405577172 31 54697379
SGTC_514 4466-0038 2.65 nM 2.36393017202264 0.00990653689085496 no 88 0.00904111021148413 75 5722064
SGTC_3067 9117431 49.47 µM 2.36298629123033 0.00993138821351009 no 89 0.00906417008683852 46 17150885
SGTC_3177 9107506 49.47 µM 2.35705348630176 0.0100888420648102 no 90 0.00921029672313034 18 8897194
SGTC_891 0929-0073 133 µM 2.35485037956305 0.0101478636929022 no 91 0.00926508254464995 26 5603632
SGTC_2873 9040596 71.43 µM 2.3456276214386 0.0103982250793478 no 92 0.00949753721433036 52 6463863
SGTC_348 k064-0012 10.7 µM 2.33800407641502 0.0106092220077839 no 93 0.0096935183400001 46 5066323
SGTC_680 0417-1641 114 µM 2.33282784747177 0.0107546015628939 no 94 0.00982859124215122 35 2835990
SGTC_2299 7976368 114.88 µM 2.33037158069602 0.0108241929846684 no 95 0.00989326023709852 34 2979718
SGTC_2913 7966556 36.57 µM 2.31229364127138 0.0113485462528202 no 96 0.0103807534349596 33 2976516
SGTC_2830 7992007 71.43 µM 2.30815933369992 0.011471517905997 no 97 0.0104951380380866 37 1952075
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.30734213539379 0.0114959613461684 no 98 0.0105178771549413 22 688751
SGTC_1977 st070720 65.3 µM 2.29118014646196 0.0119887661507558 no 99 0.0109764983677059 10 682188
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.28842909596508 0.0120744497487023 no 100 0.011056272422188 64 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2322 7413319 38.22 µM 2.28209602856379 0.0122737183827579 no 101 0.0112418357128088 70 1840400
SGTC_447 ml7 120 µM 2.27162603374626 0.0126094056271071 no 102 0.011554553551109 19 4216 Selective myosin light chain kinase inhibitor.
SGTC_1643 st009866 20.2 µM 2.26978058846333 0.012669390567424 no 103 0.011610449458595 45 3156273 YOR207C RET1
SGTC_1903 st060211 78.3 µM 2.26891387355846 0.0126976476654983 no 104 0.0116367819413412 38 688960
SGTC_1501 4491-0275 38.4 µM 2.26876893668681 0.012702378292637 no 105 0.0116411904615929 27 5104718
SGTC_1960 st011366 51.8 µM 2.26778748628858 0.0127344522196827 no 106 0.0116710812420383 36 3972846
SGTC_2083 5306046 65.942 µM 2.26728574518564 0.0127508762358796 no 107 0.0116863878497822 30 539837
SGTC_3007 9078383 71.4286 µM 2.26697332281177 0.0127611123402914 no 108 0.0116959277149917 41 6496995
SGTC_1936 st074407 74.3 µM 2.26528654671501 0.0128165002149641 no 109 0.0117475505372967 51 809813
SGTC_1912 st060209 90.8 µM 2.26528311926777 0.0128166129718102 no 110 0.0117476556333576 48 688787
SGTC_302 1094-0063 18.9 µM 2.26135966213147 0.0129462516696447 no 111 0.0118684972480753 60 5440289
SGTC_950 1165-0508 94.1 µM 2.24855997289399 0.0133770922194478 no 112 0.0122702527232706 34 6148369
SGTC_3340 9146634 11.102 µM 2.23530528522079 0.0138362427238347 no 113 0.0126986566645743 24 4907387
SGTC_1059 3448-6867 171 µM 2.22857743933934 0.0140744556310931 no 114 0.0129210167663964 42 3934407
SGTC_3132 9126706 49.47 µM 2.22418618200435 0.0142318361854537 no 115 0.0130679601748892 42 850858
SGTC_1755 st041960 45.185 µM 2.22148147070777 0.0143295242587526 no 116 0.0131591841743363 47 2257073
SGTC_637 1181-0519 7.26 µM 2.21902305572443 0.0144188170878315 no 117 0.0132425780193409 47 6252091 YGR060W ERG25
SGTC_1979 st071809 45.3 µM 2.20200076244343 0.0150503297894529 no 118 0.0138326273059338 37 4976333
SGTC_2174 5790901 200 µM 2.1983150396399 0.0151901550592394 no 119 0.0139633316920657 56 786020
SGTC_1344 1488-0097 29.1 µM 2.19136697169102 0.0154567804201257 no 120 0.014212623600318 35 747966
SGTC_3311 9131146 2.8755 µM 2.18343352438337 0.0157661218826347 no 121 0.0145019496948973 63 4900406 YPR165W RHO1
SGTC_1402 3909-7673 35.9 µM 2.18292466312199 0.015786143390257 no 122 0.014520679225187 35 5328014
SGTC_2683 piperine 63.03 µM 2.17841738472931 0.0159644394360852 no 123 0.0146874883807771 37 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3275 9138069 49.47 µM 2.17331387051227 0.0161684022929116 no 124 0.0148783511240992 38 17617007
SGTC_214 4373-3496 70 µM 2.16853379756023 0.0163614595835961 no 125 0.015059048006104 69 3779166
SGTC_3242 9133940 49.47 µM 2.16800893514799 0.0163827774809281 no 126 0.015079003356677 39 17248444
SGTC_369 0957-0393 4.5 µM 2.16735286036022 0.0164094581636789 no 127 0.0151039793746677 40 6997992
SGTC_1388 3346-4487 254 µM 2.16625529366945 0.0164541762404499 no 128 0.0151458419654775 31 3345614
SGTC_916 4466-0038 42 nM 2.15230240732893 0.0170318122316467 no 129 0.0156867721764549 71 5722064 YGL116W CDC20
SGTC_2671 danthron 100 µM 2.14491733365082 0.0173445019025183 no 130 0.0159797285402977 62 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1904 st060225 78 µM 2.14152626276136 0.0174897171080131 no 131 0.0161158114591604 33 66595
SGTC_2505 galangin 7.89 µM 2.12807427810576 0.0180760383804384 no 132 0.0166654627844712 52 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1039 k821-0043 94 µM 2.12147654491882 0.0183696806618381 no 133 0.0169408598633284 41 15992768
SGTC_2587 piperic acid 92.2 µM 2.11035104794611 0.0188740412039248 no 134 0.0174140648072964 35 5370536
SGTC_390 dec-rvkr-cmk 16.7 µM 2.10528696076806 0.0191074885140269 no 135 0.0176331682253777 48 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_499 genistein 192 µM 2.10284657247489 0.0192208607492357 no 136 0.0177395917107979 21 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_821 1114-0266 29.2 µM 2.10068297848661 0.0193218517294036 no 137 0.0178344022474353 39 3123235
SGTC_2969 9091408 28.7 µM 2.10006918661314 0.0193505839227622 no 138 0.017861377707836 47 4286311
SGTC_1799 st045822 46.1415 µM 2.0944040764059 0.0196174912777426 no 139 0.0181119999750905 38 3674992
SGTC_2297 7971671 152.32 µM 2.08940107904313 0.0198557968401417 no 140 0.0183358170917152 44 909016
SGTC_2686 alizarin 95.37 µM 2.08865371470999 0.019891605766539 no 141 0.0183694530811311 42 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1089 terbinafine 2.25 µM 2.08726309638919 0.0199583811727583 no 142 0.0184321793516962 42 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1245 0418-0076 17.2 µM 2.07147627759343 0.0207298685612678 no 143 0.0191571545543582 47 6790114
SGTC_866 0495-0101 262 µM 2.06824782529463 0.0208907121679488 no 144 0.0193083625848505 49 635694
SGTC_459 nigericin 15.3 µM 2.06479005068119 0.0210641511390366 no 145 0.0194714348295066 63 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_460 trequinsin 123 µM 2.06276067424099 0.0211665091294425 no 146 0.0195676860357267 27 5537 A vasodilator.
SGTC_1149 3909-7961 23.3 µM 2.06249453902853 0.0211799636528101 no 147 0.0195803384702836 49 735261
SGTC_2306 7482397 179.52 µM 2.06133298776006 0.021238770851067 no 148 0.0196356415809037 56 891448
SGTC_769 0302-0231 76 µM 2.05717192033238 0.0214505727480331 no 149 0.019834845771769 81 571869 YER009W NTF2
SGTC_1760 st045453 10.4495 µM 2.04736508139795 0.0219568215591498 no 150 0.0203111261016087 46 3323419 YIL048W NEO1
SGTC_2446 5162541 200 µM 2.0427060142851 0.0222008446594646 no 151 0.0205407745525977 34 1549321
SGTC_953 1188-0045 9.7 µM 2.04098994406015 0.0222913003250302 no 152 0.0206259133191901 57 6144426
SGTC_2062 5245942 200 µM 2.03509108247653 0.0226046096619793 no 153 0.0209208545537309 33 1376160
SGTC_1959 st077091 55.8 µM 2.03156946571666 0.02279341886654 no 154 0.0210986302379633 79 821356 YKL052C ASK1
SGTC_2878 9043973 25.97 µM 2.03066745009051 0.0228419930772291 no 155 0.0211443701983041 27 6465167
SGTC_3350 9150499 3.57 µM 2.02376360203239 0.0232166664535377 no 156 0.021497240464842 57 4910996 YPR165W RHO1
SGTC_534 k292-0788 63.4 µM 2.02371302198658 0.0232194304207071 no 157 0.0214998439740653 65 4146317
SGTC_833 3852-0053 558 µM 2.01533376477242 0.0236811580202964 no 158 0.0219348446810019 54 3123681
SGTC_653 0203-0016 55.2 µM 2.00573781329796 0.0242193897087442 no 159 0.0224421142855812 44 295302
SGTC_2200 6600604 21.907 µM 2.00160864136614 0.0244541345939694 no 160 0.0226634194475877 53 2904777
SGTC_540 1187-0821 17.3 µM 1.99936750349535 0.024582341718819 no 161 0.0227843026517977 64 847520
SGTC_2185 6113692 200 µM 1.97409488791295 0.0260675413188875 no 162 0.0241854772624673 55 874150
SGTC_854 0422-0053 192 µM 1.96714772702944 0.0264887156728384 no 163 0.0245830911670554 54 3596728
SGTC_1930 st074634 34.3 µM 1.96612243711375 0.0265513531788125 no 164 0.0246422345973403 67 684253 YOR116C RPO31
SGTC_150 3970-0969 77.2 µM 1.95795853817001 0.0270545347465851 no 165 0.0251174390263208 97 6615640
SGTC_1603 st002045 67.8 µM 1.95236217024955 0.0274040442852731 no 166 0.0254476105293467 32 5887985
SGTC_1725 st036284 20.55 µM 1.94963734727066 0.0275755756529079 no 167 0.0256096793475506 51 707914
SGTC_2618 avocadyne 43.43 µM 1.9449119601082 0.0278751669529433 no 168 0.025892787659337 42 3015189
SGTC_1741 st038134 10.228 µM 1.94462764645676 0.0278932786891467 no 169 0.0259099047037696 47 1272587
SGTC_2081 5214970 32.255 µM 1.93944739081711 0.0282249985618904 no 170 0.0262234423351312 38 2063512
SGTC_3108 9121785 49.47 µM 1.93796051698981 0.028320815473518 no 171 0.0263140198772485 65 17140271
SGTC_1834 st055981 52.8 µM 1.93305714570642 0.0286387181125927 no 172 0.0266145792349747 61 471719 YDL150W RPC53
SGTC_2695 st077686 51.995 µM 1.92936306880255 0.0288801733604454 no 173 0.0268429025696194 47 2876092
SGTC_1575 cyproterone acetate 48 µM 1.92893842769699 0.0289080372208456 no 174 0.0268692532616366 56 9880 An androgen receptor antagonist and liver toxin.
SGTC_1518 st038567 90.8 µM 1.92771936157315 0.0289881533918245 no 175 0.0269450212468317 49 77966
SGTC_2905 7799065 20.05 µM 1.92448499133792 0.0292016085587521 no 176 0.0271469101105984 64 1296806
SGTC_130 0136-0219 337.655 µM 1.92441249590344 0.029206407880165 no 177 0.0271514496863964 65 234244
SGTC_207 4185-0010 4.486 µM 1.92267556671772 0.0293215916015373 no 178 0.0272604036001551 80 3761753
SGTC_1327 1436-0082 2.18 µM 1.92034600380299 0.029476667606973 no 179 0.0274071045508015 59 15992205
SGTC_3165 9101544 49.47 µM 1.91979449751675 0.0295134801788628 no 180 0.0274419310947856 51 5002184
SGTC_943 3253-1379 105 µM 1.91958782144886 0.0295272854562819 no 181 0.0274549917863562 63 668464
SGTC_1955 wogonin 32.4 µM 1.91552626067901 0.0297996738141992 no 182 0.0277127117050424 45 5281703 A flavanone.
SGTC_1521 st012942 49.4 µM 1.9148742006102 0.0298435977875587 no 183 0.0277542743680375 55 24207259
SGTC_344 k064-0035 6.43 µM 1.90608785274257 0.0304407177396487 no 184 0.0283194042199912 53 5088750
SGTC_516 3992-2719 87.3 µM 1.90427222860005 0.0305653334883953 no 185 0.028437369565838 44 5350887 YDR037W KRS1
SGTC_1837 st055472 66.5 µM 1.89506891997581 0.0312035204663064 no 186 0.0290416357841254 40 676091
SGTC_1905 st060207 84.5 µM 1.89244978243268 0.0313871414705141 no 187 0.0292155392456558 61 1948547
SGTC_3247 9135149 49.47 µM 1.88944201261036 0.0315991096634042 no 188 0.0294163129458905 96 8934436 YOR116C RPO31
SGTC_720 r052-1644 49.9 µM 1.87894113685805 0.0323484385162141 no 189 0.0301262655237265 63 1422863 YOR257W CDC31
SGTC_1033 k072-0102 21.3 µM 1.87550656837764 0.0325966842702741 no 190 0.0303615333575045 54 5965931
SGTC_2744 captopril 92.04 µM 1.87457251052211 0.0326644677502588 no 191 0.0304257789615006 16 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1830 st055982 50.3 µM 1.87143323679524 0.0328931334566341 no 192 0.0306425278243567 51 455313 An antimicrobial agent.
SGTC_2470 5664817 21.68 µM 1.86945557357899 0.0330378633338683 no 193 0.0307797295057711 45 2859561
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.86532220342406 0.0333420474254758 no 194 0.0310681273637679 78 368090
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.85542375897524 0.0340798790990407 no 195 0.0317678685945747 53 6710655
SGTC_105 0111-0055 734.78 µM 1.85308397613799 0.0342562347839309 no 196 0.0319351615868197 45 5179370
SGTC_2075 5212009 200 µM 1.85267074104388 0.0342874592211072 no 197 0.0319647831000974 48 780898
SGTC_202 3594-0513 34.79 µM 1.84700340588738 0.0347180536217817 no 198 0.0323733233355224 62 708429
SGTC_2499 avocadenofuran 51.48 µM 1.84659214652145 0.0347494724478333 no 199 0.0324031366338571 51 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2882 9058044 58.44 µM 1.84528140808966 0.0348497642538464 no 200 0.032498306779079 62 18076804
SGTC_2228 7354201 200 µM 1.83710508195671 0.0354807571691026 no 201 0.0330971920479922 57 753451
SGTC_449 xestospongin c 11.1929 µM 1.83255251753026 0.0358361336472081 no 202 0.0334345724596629 51 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_376 3970-0862 59.1 µM 1.82783978471494 0.0362070797571121 no 203 0.0337868001801671 80 3135186
SGTC_23 0213-0011 39.996 µM 1.82758998184199 0.0362268295162464 no 204 0.0338055552240668 68 627608
SGTC_696 1560-0013 611 µM 1.81896647515568 0.0369140414278313 no 205 0.0344582724575363 74 1650269
SGTC_353 1988-1175 58.3 µM 1.81260051830594 0.0374281561897426 no 206 0.0349467289097597 80 2788357
SGTC_551 k048-0028 34.9 µM 1.81253005788077 0.0374338791307149 no 207 0.0349521669362231 76 6836383
SGTC_3198 9112019 49.47 µM 1.80688223974912 0.0378949363261148 no 208 0.0353903211331169 68 45595555
SGTC_213 1246-0773 967 nM 1.80406030850233 0.0381270335937627 no 209 0.0356109265638573 46 6251622
SGTC_2435 5706476 10.6 µM 1.7991325782821 0.0385351071668901 no 210 0.0359988556774469 54 5725375
SGTC_2061 5245884 80.95 µM 1.79824894474452 0.0386086573505425 no 211 0.0360687832296921 60 573863
SGTC_1491 4138-0063 26.5 µM 1.79662402747924 0.0387442076442019 no 212 0.0361976636411216 49 23883227
SGTC_2524 avocatin b 10.57 µM 1.79464740903452 0.0389096191452655 no 213 0.0363549472843338 36 6710748
SGTC_332 4112-0506 40.9 µM 1.79131843752197 0.0391895006403077 no 214 0.0366211045312856 95 2790355
SGTC_3191 9110352 49.47 µM 1.78915419388241 0.0393723356139107 no 215 0.036794993169719 48 17122424
SGTC_196 k015-0023 18.111 µM 1.78547314513443 0.0396849036955115 no 216 0.0370923017545572 40 5211998
SGTC_2741 miltefosine 3.04 µM 1.78529445977719 0.0397001275682155 no 217 0.0371067835197777 35 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1922 5578187 25 µM 1.78016163944535 0.0401394716103274 no 218 0.0375247556548328 70 1350412
SGTC_533 1222-0222 6.71 µM 1.77947969073741 0.040198139176307 no 219 0.0375805758182437 71 3982874
SGTC_15 0266-0086 27.098 µM 1.77884539819877 0.0402527694207099 no 220 0.037632555977277 84 1712902 YIL048W NEO1
SGTC_3034 9090421 49.47 µM 1.77836875828955 0.0402938610559951 no 221 0.0376716551463871 37 17173761
SGTC_797 k781-0471 270 µM 1.77732096309033 0.0403843123673792 no 222 0.0377577232440743 70 23738129
SGTC_1031 k035-0009 16 µM 1.77527590242737 0.0405613279205067 no 223 0.0379261711457871 59 5180959
SGTC_1607 st000305 50.6 µM 1.76873473390189 0.0411317487721372 no 224 0.038469076476738 61 5457690
SGTC_2111 5486399 200 µM 1.76805655445923 0.0411912595573694 no 225 0.038525724769362 78 689674
SGTC_2241 6772625 37.8075 µM 1.76439490295078 0.0415137794120505 no 226 0.0388327578649389 68 2285411
SGTC_827 3253-0474 693 µM 1.75734269507066 0.0421407051073813 no 227 0.0394297072797156 83 5402065
SGTC_1524 corynanthine 62.1 µM 1.74750868179362 0.0430276954557746 no 228 0.0402745701353338 70 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2534 helenine 20.12 µM 1.74723017199957 0.0430530339412232 no 229 0.0402987100032072 76 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.74460359491668 0.0432925901295969 no 230 0.0405269473224963 72 688669
SGTC_968 1309-0633 340 µM 1.74228889481929 0.0435045928408573 no 231 0.0407289528232159 71 3761976
SGTC_1132 3456-3614 2.5 µM 1.73979137482818 0.0437342790280816 no 232 0.040947828773904 69 3125502
SGTC_384 k007-0144 5.16 µM 1.7389701482324 0.0438100171074511 no 233 0.0410200069606794 91 6824886
SGTC_2253 7938677 135.83 µM 1.7284872749929 0.044786131917067 no 234 0.0419504502358257 59 2301972
SGTC_488 nitrendipine 139 µM 1.72295741442843 0.0453080582804649 no 235 0.042448113196192 51 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2986 9022445 71.43 µM 1.72166662613637 0.0454305887603968 no 236 0.0425649631476467 73 6459286
SGTC_3200 9114385 49.47 µM 1.71429328625641 0.0461356345008668 no 237 0.04323743777184 71 17018030 YLR208W SEC13
SGTC_668 1682-0499 62.6 µM 1.71047116834341 0.0465045525488295 no 238 0.0435893902538517 77 682214
SGTC_1503 4585-0012 61.3 µM 1.69960341281154 0.0475664787282439 no 239 0.0446027739929099 67 2922052
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.69913788213862 0.0476123976419448 no 240 0.0446466035834357 93 1273210
SGTC_2026 5148700 152 µM 1.69573267502971 0.0479493603393166 no 241 0.0449682587803922 74 79838
SGTC_3281 9140613 49.47 µM 1.69484994911614 0.0480370214340019 no 242 0.0450519446348231 65 16013766
SGTC_387 norethindrone acetate 66.7 µM 1.69463928068495 0.0480579612859258 no 243 0.0450719353374489 72 541197
SGTC_2564 betulinic acid 100 µM 1.6911991461052 0.048400935720268 no 244 0.0453993870255676 78 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2104 5389443 200 µM 1.69117671583154 0.0484031783798278 no 245 0.0454015283289633 84 2244536
SGTC_2826 7992541 19.48 µM 1.68899779558763 0.0486214311352896 no 246 0.0456099262012751 83 2985066
SGTC_1902 st060212 70.5 µM 1.68086507519843 0.049443006282423 no 247 0.0463945625195584 77 688944
SGTC_687 k029-0044 34.9 µM 1.67931927019263 0.0496004111991692 no 248 0.0465449186806434 48 5829338
SGTC_921 1561-0023 372 µM 1.67737907897466 0.0497985409956208 no 249 0.0467341888740713 89 24050882
SGTC_1716 st033144 30.6155 µM 1.67008894016514 0.0505486491466949 no 250 0.0474508840086396 79 674617
SGTC_2951 9072950 58.06 µM 1.65502563997087 0.0521270668136579 no 251 0.048959648514956 75 16488155
SGTC_3222 9128301 49.47 µM 1.65175088241742 0.0524753418552428 no 252 0.0492926726570688 97 4911358
SGTC_2191 5911152 200 µM 1.65025728289183 0.0526348004013614 no 253 0.0494451626023574 70 2875902
SGTC_3192 9110362 49.47 µM 1.6457021557305 0.0531234870130148 no 254 0.0499125474946696 71 16649480
SGTC_1359 1582-0056 520 nM 1.64240694694407 0.0534792433683863 no 255 0.0502528481008838 76 3661189
SGTC_3225 9130819 49.47 µM 1.63103397528687 0.05472160798235 no 256 0.0514415753709314 99 4547121
SGTC_3038 9091290 49.47 µM 1.62675443430956 0.0551949641805214 no 257 0.0518946313073204 68 25236843
SGTC_448 monastrol 171 µM 1.6266695296451 0.0552043880269341 no 258 0.0519036517604025 63 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.62332622003912 0.0555764842674877 no 259 0.0522598436778764 67 4213774
SGTC_935 2996-0153 430 µM 1.6207731246449 0.0558619639289825 no 260 0.0525331521582755 82 23738523
SGTC_3228 9131799 49.47 µM 1.61966106457675 0.0559866723887729 no 261 0.052652552173107 87 17015818
SGTC_3212 9128307 49.47 µM 1.61814896423406 0.0561565942767043 no 262 0.0528152492124662 81 27243542
SGTC_1924 st058459 75.1 µM 1.61780961462232 0.056194784418174 no 263 0.0528518168585638 54 688683
SGTC_79 0052-0007 94.094 µM 1.61665499854073 0.0563248774025078 no 264 0.0529763864541752 76 2801472
SGTC_1612 st002233 45.4 µM 1.61266195694568 0.0567766126416089 no 265 0.0534089849595842 82 1035021
SGTC_648 0375-0473 33.3 µM 1.61208429906183 0.0568421990496002 no 266 0.0534717984417164 88 1713139
SGTC_716 1683-5115 658 µM 1.60993192565607 0.0570871017771704 no 267 0.0537063591944024 83 723597
SGTC_1633 st005664 67.9 µM 1.60938027143066 0.0571500039882119 no 268 0.0537666082294196 75 2063822
SGTC_1560 lithocholic acid 53.1 µM 1.60850103494178 0.0572503714227408 no 269 0.053862744859518 63 9903 A bile acid which acts as a detergent.
SGTC_2261 9010538 184.68 µM 1.60768173932139 0.057344021235956 no 270 0.0539524499509438 77 6457250
SGTC_1251 0490-5699 265 µM 1.60700393379957 0.0574215890589892 no 271 0.0540267525852287 83 3883818
SGTC_2426 5582046 32.21 µM 1.60347179506898 0.0578271424744322 no 272 0.0544152656604534 78 2251934
SGTC_1331 1472-0049 76.2 µM 1.60343459259257 0.0578314259441656 no 273 0.0544193694290596 99 24051409
SGTC_3295 9122362 53.5725 µM 1.60150739331618 0.0580536638061339 no 274 0.0546322919064685 103 4730473
SGTC_2572 astragaloside iv 100 µM 1.59794144094904 0.058466646158214 no 275 0.0550280050755523 89 45006101 An anti-inflammatory agent.
SGTC_227 fluconazole 33.516 µM 1.597403415611 0.0585291560966875 no 276 0.0550879057968813 140 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_40 0327-0103 19.753 µM 1.59495813750935 0.0588139197546754 no 277 0.0553607987090551 74 409036
SGTC_1820 st053765 18.6 µM 1.59085153707189 0.0592945968328048 no 278 0.0558214956619118 78 3690829
SGTC_718 1130-0073 349 µM 1.5890632971963 0.0595048704365055 no 279 0.0560230515053377 81 6740020
SGTC_1441 4106-0040 13 µM 1.587477746027 0.059691798949625 no 280 0.0562022416258801 80 2904180
SGTC_783 0848-0141 92.7 µM 1.58367580913453 0.0601419025801017 no 281 0.0566337562685446 109 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_988 1497-1057 103 µM 1.57838529379798 0.0607726521946098 no 282 0.0572385608201439 83 3533044
SGTC_2457 5731572 11.68 µM 1.57661578885641 0.0609847680363834 no 283 0.0574419787792956 101 2865357
SGTC_1345 1488-0192 31.4 µM 1.57174755350519 0.0615713248929125 no 284 0.0580045545108779 81 658348
SGTC_1845 st056753 3.01 µM 1.56881284024612 0.0619270410876151 no 285 0.0583457778017254 79 5375839
SGTC_1040 k898-0338 155 µM 1.56847989353635 0.061967498607695 no 286 0.0583845893643412 79 20969351
SGTC_1029 k015-0030 64.7 µM 1.56655156616177 0.062202222220274 no 287 0.0586097732125575 96 2208316
SGTC_2363 9053361 176 µM 1.56284260656779 0.0626556406532436 no 288 0.0590448099555917 97 6469797 YMR079W SEC14
SGTC_3176 9106582 49.47 µM 1.56191485016493 0.062769460216748 no 289 0.0591540248090188 35 17018027
SGTC_3306 9127676 59.7925 µM 1.55484607253152 0.0636419741453155 no 290 0.0599913666999573 70 41905287
SGTC_823 0417-1665 178 µM 1.55193385115831 0.0640041686394172 no 291 0.0603390260797665 92 3429856
SGTC_1818 st052136 56.3 µM 1.5475040373701 0.0645581775903548 no 292 0.0608708758366588 116 674169
SGTC_640 3381-0960 37.1 µM 1.53931768461397 0.0655917876172177 no 293 0.0618633793296593 97 1745025
SGTC_758 0868-0029 16 µM 1.53804569843871 0.0657535341842699 no 294 0.0620187208049944 83 762687
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.53741183465574 0.0658342520451915 no 295 0.0620962450470293 107 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1493 4348-0038 111 µM 1.536719848292 0.0659224590477956 no 296 0.0621809642288091 130 800424
SGTC_3211 9128781 49.47 µM 1.53643714581603 0.0659585212679261 no 297 0.0622156011346181 95 17194361
SGTC_1197 1601-0112 267 µM 1.53531375935899 0.0661019742756874 no 298 0.0623533879755446 97 7350313
SGTC_413 propylparaben 100 µM 1.53451347623088 0.066204315314089 no 299 0.0624516902506228 97 7175 A pharmaceutical preservative.
SGTC_1192 1488-0095 21.4 µM 1.52238985750102 0.0677697503329961 no 300 0.0639557123390696 81 915875
SGTC_587 k089-0003 57 µM 1.52089755066414 0.0679644011102655 no 301 0.0641427743595383 66 9659696
SGTC_1975 st070967 30.8 µM 1.52088672178298 0.0679658151639642 no 302 0.0641441333223472 131 261391
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.51982802687007 0.0681041710519131 no 303 0.0642771015845269 80 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3119 9125183 49.47 µM 1.51929704011826 0.068173645047538 no 304 0.0643438722207893 59 22695334
SGTC_1757 st041620 31.8375 µM 1.51893084580006 0.0682215895606844 no 305 0.0643899518976972 70 5289815
SGTC_346 4513-0042 7.16 µM 1.51803958784569 0.0683383875217915 no 306 0.0645022095537659 109 2827372
SGTC_1982 st072467 71.9 µM 1.51785389470291 0.0683627417296313 no 307 0.0645256175072084 114 3163533
SGTC_2333 9017922 200 µM 1.50729682979447 0.06975837544797 no 308 0.065867294917134 81 3163164
SGTC_2156 5649887 115 µM 1.50536068709795 0.0700166949645138 no 309 0.0661156852601975 109 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1636 st007707 68.9 µM 1.50433651235256 0.0701536373148734 no 310 0.0662473711295586 89 403051
SGTC_619 1652-1634 108 µM 1.5036110718499 0.0702507605043082 no 311 0.0663407693200258 93 5400454
SGTC_1854 st056233 32.9 µM 1.49850284442664 0.0709375887398431 no 312 0.0670013270823978 106 5393174
SGTC_1992 st073643 23.3 µM 1.49490542917722 0.0714243673705916 no 313 0.0674695625846243 98 3161292
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.49153640478366 0.0718825624636793 no 314 0.0679103603458263 95 2724 A muscle relaxant with antifungal properties.
SGTC_257 daunorubicin 18.5 µM 1.48864328152632 0.0722778299773031 no 315 0.0682906639649971 100 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2858 9025781 8.96 µM 1.48783053056162 0.0723891696856177 no 316 0.0683977959631878 112 4894980 YPL153C RAD53
SGTC_2757 clomiphene 4.22 µM 1.4871277041914 0.072485556606131 no 317 0.0684905428658737 135 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1147 3809-1045 12.3 µM 1.48686877577794 0.0725210913039617 no 318 0.0685247362170425 110 325925
SGTC_2009 4012297 12.05 µM 1.48637242976189 0.0725892459137452 no 319 0.068590319076131 101 45595307
SGTC_566 0958-0068 16.5 µM 1.48008205011637 0.0734572508202065 no 320 0.0694256756158536 103 6815365
SGTC_1624 st003710 6.25 µM 1.4776821204596 0.0737904993865224 no 321 0.0697464411223483 85 24207033
SGTC_14 0354-0009 295 µM 1.47754783086421 0.0738091806044967 no 322 0.069764423406998 109 1713507
SGTC_1295 1013-0063 9.78 µM 1.47619592007487 0.0739974482629679 no 323 0.0699456522500038 100 6826038
SGTC_2376 9072922 81.32 µM 1.47196963311314 0.0745883693928417 no 324 0.0705145390241246 99 17087968
SGTC_211 3455-0679 143.504 µM 1.46958282774858 0.0749236811609219 no 325 0.070837386973087 80 748649
SGTC_2252 omeprazole 400 µM 1.46888913772083 0.0750213499526713 no 326 0.0709314306684334 63 4594 A proton pump inhibitor.
SGTC_3028 9087778 49.47 µM 1.46506935086141 0.0755609010138358 no 327 0.0714509988360441 96 17217395
SGTC_756 0508-1999 28.3 µM 1.46253119307982 0.0759210516723371 no 328 0.071797851458106 109 6753853
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.45767547232694 0.0766136921251387 no 329 0.0724650078794693 142 16725076
SGTC_2390 9097792 176.6 µM 1.4561373332305 0.0768340981059518 no 330 0.0726773294632635 97 4497149
SGTC_853 0419-0306 21 µM 1.4509392971778 0.0775825130481816 no 331 0.0733983820379465 127 762713
SGTC_3288 9119690 36.221 µM 1.44947968666047 0.0777936604061574 no 332 0.0736018345638357 122 17595618 YKL019W RAM2
SGTC_1146 3579-1023 7 µM 1.44898538137895 0.0778652654208805 no 333 0.0736708325497324 113 X1146
SGTC_765 1319-0117 244 µM 1.4471359030388 0.0781336244041916 no 334 0.0739294320959013 97 3487746 YGL099W LSG1
SGTC_1419 3993-2473 62.6 µM 1.44529820418038 0.0784009684942293 no 335 0.0741870710455415 103 704026
SGTC_1100 amiodarone 5.07 µM 1.4452860050541 0.0784027455087139 no 336 0.0741887836086892 79 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1246 0422-0085 105 µM 1.44432221264448 0.0785432351358583 no 337 0.0743241801723675 124 264295
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.44232259534025 0.0788353229313566 no 338 0.0746056943918806 104 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_910 3454-3003 490 µM 1.44076505102064 0.0790634058931104 no 339 0.0748255350460205 122 820824
SGTC_90 0870-0863 4.608 µM 1.44048989465999 0.0791037510030728 no 340 0.0748644234937388 110 1738164
SGTC_296 1222-0039 74.9 µM 1.43946878394171 0.0792536087957497 no 341 0.0750088740846873 87 5984176
SGTC_2178 5812956 200 µM 1.43917283074973 0.0792970829152564 no 342 0.0750507805695138 96 5403383
SGTC_1292 0kpi-0043 232 µM 1.43868544080912 0.0793687175273407 no 343 0.0751198330947699 99 3333905
SGTC_2394 5221648 200 µM 1.43545785098218 0.0798443324174565 no 344 0.0755783354486225 127 788586
SGTC_816 0325-0417 81.3 µM 1.43312645974696 0.0801892228612115 no 345 0.0759108505170951 109 68101
SGTC_2841 9004761 38.96 µM 1.43222184726009 0.0803233479940194 no 346 0.0760401705941001 82 2991039
SGTC_3322 9139058 2.11 µM 1.4321817868646 0.0803292915884394 no 347 0.0760459013569073 109 4908926 YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM 1.42957961400829 0.0807160774862266 no 348 0.0764188549743273 121 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2687 chenodiol 100 µM 1.42825357384795 0.0809137196980401 no 349 0.0766094427177742 110 5702181 A cholesterol synthesis inhibitor.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.42779719221193 0.0809818264161099 no 350 0.0766751206255034 91 6312947
SGTC_1771 st048882 4.1505 µM 1.42712309336961 0.0810825026410391 no 351 0.0767722085501205 111 4580403
SGTC_1751 st044839 27.194 µM 1.4270576642749 0.0810922794605831 no 352 0.0767816370313385 96 5291326
SGTC_1088 bifonazole 369 nM 1.42249349307993 0.0817764838837185 no 353 0.0774415195757304 89 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_847 0342-0274 5.54 µM 1.4165651170341 0.0826716783046299 no 354 0.0783050566484834 127 18097
SGTC_1664 st014217 9.02 µM 1.41506589854887 0.0828992268036384 no 355 0.078524587774424 107 3982782
SGTC_2284 7945075 39.21 µM 1.41478939676028 0.082941245127181 no 356 0.0785651269431405 111 1245402
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.4140880035217 0.0830479035255388 no 357 0.0786680325126519 124 5024745
SGTC_2096 5468907 200 µM 1.41317692172518 0.083186602507601 no 358 0.0788018552157263 101 759785
SGTC_269 exalamide 29 µM 1.41245404103859 0.0832967744687473 no 359 0.0789081569796818 117 3316 A derivative of salicylamide.
SGTC_2776 terbinafine 19.92 µM 1.41241220475337 0.0833031539610711 no 360 0.0789143124540935 110 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.41115819117506 0.0834945453617965 no 361 0.0790989874236206 103 16623 A steroid.
SGTC_1950 st077106 7.18 µM 1.41102125550454 0.0835154649009422 no 362 0.0791191733494659 89 13831864
SGTC_3263 9137018 49.47 µM 1.40963980018305 0.0837267289393647 no 363 0.0793230343210803 124 43844957
SGTC_2767 sibutramine 71.45 µM 1.40689165469424 0.0841481922973369 no 364 0.0797297592847693 85 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3026 9090633 49.47 µM 1.40654706064093 0.0842011523841592 no 365 0.0797808702400448 100 25236842
SGTC_502 l-744,832 89.3 µM 1.40602151257614 0.0842819711606384 no 366 0.0798588684113547 92 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2196 6573537 42.6665 µM 1.40599506228657 0.0842860402241249 no 367 0.0798627955022463 114 2903087
SGTC_2211 7117706 200 µM 1.4038051803048 0.0846234392389045 no 368 0.0801884354830361 94 822771
SGTC_1684 st024538 14.6195 µM 1.38629504435033 0.0873577731947487 no 369 0.0828284147313362 105 6732859
SGTC_1778 st046819 58.9 µM 1.3832346700248 0.0878423688547963 no 370 0.0832964611546409 133 671715
SGTC_3055 9094636 49.47 µM 1.37980647491384 0.0883875849682466 no 371 0.0838231192489516 136 25236176
SGTC_3303 9125618 40.5795 µM 1.37735606684686 0.0887788376084273 no 372 0.0842010943712751 108 22695467
SGTC_1773 st048542 73.5835 µM 1.3711627276803 0.0897734647958512 no 373 0.0851621171453788 163 3237138
SGTC_3092 9117248 49.47 µM 1.36897108612722 0.0901274113019137 no 374 0.0855041565974275 111 17141857
SGTC_3272 9137413 49.47 µM 1.36728369869176 0.0904006271801284 no 375 0.0857681996069929 112 17614870
SGTC_2996 9066192 71.4286 µM 1.36336283544217 0.0910378536770179 no 376 0.0863840938921324 111 6472854
SGTC_1690 st023502 41.2 µM 1.35757127099921 0.0919851966704477 no 377 0.0872998820653513 123 24207482
SGTC_49 0717-0965 32.132 µM 1.35755035561272 0.0919886310398345 no 378 0.0873032023843743 111 5889349 YGL099W LSG1
SGTC_2592 piperlongumine 83.33 µM 1.35005727479818 0.0932251365545209 no 379 0.0884988058698254 118 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1198 1612-1005 86.7 µM 1.34708327002089 0.0937192956301984 no 380 0.0889767078323077 137 6998509
SGTC_2441 5730946 39.09 µM 1.34521062325574 0.0940314442753937 no 381 0.0892786132784344 114 1774275
SGTC_361 000s-0510 1.45 µM 1.34420524509219 0.0941993453990743 no 382 0.0894410130171098 108 660
SGTC_2365 9042475 200 µM 1.34232836692059 0.0945133812129827 no 383 0.0897447748218873 117 6464479
SGTC_401 neomycin 50 µM 1.34061030040606 0.094801520985764 no 384 0.0900235056093778 104 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2213 7173844 200 µM 1.33746950950346 0.0953299406282552 no 385 0.0905347142401169 118 892728
SGTC_2653 dihydrofissinolide 100 µM 1.33548592349947 0.0956647826605013 no 386 0.0908586796825861 108 6857746
SGTC_3085 9117376 49.47 µM 1.33457666724577 0.0958185598745419 no 387 0.0910074694236627 127 16480349
SGTC_1448 4255-0083 152 µM 1.33437602598698 0.0958525176371509 no 388 0.0910403264771375 138 5399660
SGTC_1562 morin hydrate 59.1 µM 1.33423688749831 0.0958760714892278 no 389 0.0910631169904301 118 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.32671279858593 0.0971561230553411 no 390 0.0923018528085115 113 61125 An anti-inflammatory.
SGTC_981 1488-1094 54.9 µM 1.32647201569436 0.0971972928629981 no 391 0.0923416992627632 110 3449522
SGTC_2266 7929956 200 µM 1.32413579420694 0.0975974121450264 no 392 0.092728974858338 129 2967153
SGTC_2416 tofa 880 nM 1.32268523356555 0.0978464533683376 no 393 0.0929700380845384 102 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2377 9073351 62.6 µM 1.3194381325143 0.0984056235414704 no 394 0.0935113402758416 136 7337946 YHR072W ERG7
SGTC_2543 pimpinellin 60.67 µM 1.31478560647921 0.0992108894303662 no 395 0.0942909830832348 117 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1851 st056236 18.9 µM 1.30698872441407 0.100571170932619 no 396 0.0956082704866919 124 5393171
SGTC_108 0509-0257 621.132 µM 1.30692598335532 0.100582171949059 no 397 0.0956189252684458 142 536624
SGTC_987 1497-1013 404 µM 1.30433876184387 0.101036580086307 no 398 0.0960590523559728 117 1676435
SGTC_3352 9151559 45.5865 µM 1.30165792206546 0.101509007612367 no 399 0.0965166749027996 102 17159339
SGTC_2371 9071574 200 µM 1.30100955012645 0.101623507336773 no 400 0.0966275929088615 125 45596039
SGTC_925 2064-1272 59.6 µM 1.29498574662264 0.102691783555621 no 401 0.0976625732429319 139 6815817
SGTC_2954 9074818 52.69 µM 1.29138292858246 0.103334604202344 no 402 0.0982854636377715 136 16648742
SGTC_2462 5162487 171.77 µM 1.28740505617323 0.104047730299619 no 403 0.098976571463504 125 2259986
SGTC_1403 3909-7815 62.9 µM 1.28708192446876 0.104105815491342 no 404 0.0990328674678501 122 6615483
SGTC_2651 TUB2.036 5 µM 1.28449765715706 0.104571201685836 no 405 0.0994839414037898 150 15992207 YFL037W TUB2
SGTC_1143 3454-2408 5.08 µM 1.28303966506954 0.104834427348635 no 406 0.0997390899786964 103 X1143
SGTC_1817 st052116 64.4 µM 1.28149338760496 0.105114115903099 no 407 0.100010210511989 99 4361398
SGTC_792 4534-1957 155 µM 1.27444250828829 0.10639631548151 no 408 0.101253317741194 114 1717904
SGTC_1376 2910-0861 41.3 µM 1.27326690307234 0.106611192667665 no 409 0.101461673493937 143 1112859
SGTC_1193 1488-0126 41.5 µM 1.27012719392835 0.10718660388365 no 410 0.102019663177535 116 1384710
SGTC_472 calcifediol 10 µM 1.26965796128668 0.107272791649944 no 411 0.102103246714649 107 5283731 A vitamin D metabolite.
SGTC_473 2-arachidonoylglycerol 10 µM 1.26947585834292 0.107306253429679 no 412 0.102135697789004 133 5282280 An endocannabinoid.
SGTC_2733 amorolfine 100 µM 1.26794225792299 0.107588354136954 no 413 0.102409285879248 137 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_244 nsc-207895 1.295 µM 1.26752944601548 0.107664380719623 no 414 0.102483020794503 80 42640
SGTC_2182 6325192 200 µM 1.26721674768391 0.107721995383221 no 415 0.102538899485835 127 736248
SGTC_2992 9074591 71.4286 µM 1.26550765217556 0.108037288685968 no 416 0.102844703523382 120 17741321
SGTC_2883 9059145 45.46 µM 1.26463127075793 0.108199220672142 no 417 0.103001768961101 154 16476510
SGTC_1136 pergolide 1.05886 µM 1.26441504197742 0.1082392008581 no 418 0.103040548357218 149 47811 A dopamine receptor agonist.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.25581723841171 0.109837540395489 no 419 0.104591120063145 110 688667
SGTC_2780 5215298 71.43 µM 1.25522995223396 0.10994733226466 no 420 0.10469764764678 155 2834131
SGTC_661 1304-0007 33.6 µM 1.25386448073168 0.110202908540142 no 421 0.10494563362945 140 3117130
SGTC_3284 9108171 64.8615 µM 1.24891996959212 0.111131940826517 no 422 0.105847173413281 128 8687505
SGTC_3054 9094397 49.47 µM 1.24640711037235 0.111606229581117 no 423 0.10630748608235 144 2598354
SGTC_2580 diallyl disulphide 81.36 µM 1.24385624884688 0.11208917054439 no 424 0.106776237030705 138 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_291 SEC14.278 35.5 µM 1.24078060388008 0.112673450165446 no 425 0.10734340417549 130 1068044
SGTC_1415 3966-0071 78.1 µM 1.23820850622667 0.113163738400474 no 426 0.107819379156126 126 2893185
SGTC_1871 st057448 67.3 µM 1.237815984706 0.113238693759669 no 427 0.10789215002161 141 691747
SGTC_689 0833-0039 98 µM 1.23626446724428 0.113535316033397 no 428 0.108180137211098 142 5374726
SGTC_2323 6148992 148.28 µM 1.2356405042954 0.113654762611591 no 429 0.108296110882145 132 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1307 1187-1599 12.2 µM 1.23481378221171 0.113813161752582 no 430 0.108449908415513 153 1538471
SGTC_1654 st012436 41.8 µM 1.23477970157981 0.11381969494313 no 431 0.108456251906294 110 4323132
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.23084821924303 0.114575147026268 no 432 0.109189818578738 141 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_701 4424-0219 185 µM 1.23068558078687 0.11460647542545 no 433 0.109220241538029 139 2911779
SGTC_131 0141-0277 33.849 µM 1.22873241395147 0.114983182473471 no 434 0.109586074481839 160 1547771
SGTC_205 1486-1330 71.903 µM 1.22867269999486 0.114994713353742 no 435 0.10959727289686 131 4118834
SGTC_1910 st062352 60.4 µM 1.22763480229109 0.115195264784727 no 436 0.109792045585432 121 2245730
SGTC_1451 4152-0210 104 µM 1.22587068115926 0.115536713559205 no 437 0.11012367173889 132 659563
SGTC_3113 9123498 49.47 µM 1.22283658007972 0.11612564993001 no 438 0.110695713059022 148 8897275
SGTC_1900 st060200 72.8 µM 1.22162074601528 0.116362247248144 no 439 0.110925539779987 142 688945
SGTC_2557 derrustone 83.84 µM 1.22136860518947 0.116411355810264 no 440 0.110973244226452 144 629853 An antioxidant.
SGTC_2832 7992762 51.95 µM 1.21925619580655 0.116823359807623 no 441 0.111373484416892 130 2985177
SGTC_3302 9125395 16.351 µM 1.21467686222435 0.117720058866412 no 442 0.112244680330573 130 17599668
SGTC_395 anisomycin 6.25 µM 1.21406903148408 0.11783944603558 no 443 0.112360682292319 139 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1237 0330-0133 46.1 µM 1.21276331260603 0.118096198640618 no 444 0.112610162885558 156 X1237 YHR072W ERG7
SGTC_435 c-PAF 6.7 µM 1.212623935293 0.118123628726255 no 445 0.112636816727208 143 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2346 9031566 143.75 µM 1.21261858603614 0.118124681573978 no 446 0.112637839782928 129 4771086
SGTC_1323 1348-1351 11.2 µM 1.21234810167305 0.118177927312028 no 447 0.11268957909226 136 6989654
SGTC_2452 5863136 48.41 µM 1.20724828835132 0.119185020406696 no 448 0.113668269488224 127 2184096
SGTC_1572 epiandrosterone 68.9 µM 1.20663753284259 0.119306035232082 no 449 0.113785882845216 129 441302 A steroid.
SGTC_352 k048-0007 5.11 µM 1.20561771189925 0.119508295334614 no 450 0.113982463324433 170 6811911
SGTC_180 1486-1293 102.781 µM 1.20413643843449 0.119802505525442 no 451 0.114268424076511 144 4140536
SGTC_1775 st081588 35.1725 µM 1.20250721457187 0.120126690934812 no 452 0.114583536296645 153 1426443 YGL099W LSG1
SGTC_1590 st077108 57.8 µM 1.20234015659 0.120159967293103 no 453 0.114615882318988 127 5489485
SGTC_1787 fluconazole 80 µM 1.20078129828293 0.120470790123667 no 454 0.114918024105431 136 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2728 chlorpromazine 9.18 µM 1.19943766272389 0.120739153411605 no 455 0.115178905125139 139 2726 A thorazine and dopamine antagonist.
SGTC_1335 1486-0900 202 µM 1.19913387422125 0.12079988713555 no 456 0.115237947183029 125 X1335
SGTC_3094 9117742 49.47 µM 1.19582599021412 0.121462594870005 no 457 0.115882235653801 176 17149698
SGTC_1429 4049-0205 9.46 µM 1.1940628842295 0.121816861166225 no 458 0.116226685231094 129 22774478
SGTC_704 1310-0270 142 µM 1.19338726287369 0.12195280803713 no 459 0.116358870500396 137 5718033
SGTC_1737 st035557 69.7 µM 1.19246869673 0.122137810538372 no 460 0.116538758928343 148 5716916
SGTC_1522 st012842 45.6 µM 1.18485429936906 0.12367896610303 no 461 0.118037529616142 148 3491067 YOR116C RPO31
SGTC_471 1-acyl-paf 4 µM 1.18221962178071 0.124215382756631 no 462 0.11855928444984 132 16759367
SGTC_3163 9099914 49.47 µM 1.17951754216181 0.124767210611492 no 463 0.119096077837544 161 16268368
SGTC_2752 diclazuril 33.15 µM 1.17884772647253 0.124904267208373 no 464 0.119229407965185 144 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2551 apiole 73.87 µM 1.17823255284409 0.125030235668877 no 465 0.11935195410286 121 10659 A possible DNA adduct former.
SGTC_1510 1123-0200 71.5 µM 1.17414196434638 0.125870118043906 no 466 0.120169083633176 171 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3037 9091026 49.47 µM 1.17322663567883 0.126058591431245 no 467 0.120352466706575 147 25236398 YIL048W NEO1
SGTC_217 ketoconazole 989 nM 1.17056575309879 0.126607605148985 no 468 0.120886684909644 150 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1393 3470-5649 58.2 µM 1.17014195584496 0.126695199761147 no 469 0.120971923354533 116 4108395
SGTC_159 3970-0959 50 µM 1.16884240030143 0.126964067857974 no 470 0.121233566912257 172 6615653
SGTC_1240 0356-0016 42.1 µM 1.16563731718303 0.127628871800994 no 471 0.121880556681009 138 4305613
SGTC_2795 7780010 54.55 µM 1.15980497595505 0.12884482631217 no 472 0.123064108857784 151 953673
SGTC_723 4182-0001 115 µM 1.15977457392024 0.12885118565643 no 473 0.123070299351516 140 744821 YLR208W SEC13
SGTC_2680 butyl paraben 22.24 µM 1.15974955022113 0.128856420150915 no 474 0.12307539486675 163 7184 An antifungal and steroid mimetic.
SGTC_411 enrofloxacin 100 µM 1.15714331298932 0.129402404566797 no 475 0.123606906604963 136 71188 A bacterial gyrase inhibitor.
SGTC_1539 benzyladenosine 56 µM 1.15494044349516 0.129865135352197 no 476 0.124057408024329 152 92208 A nucleotide analog.
SGTC_325 2810-4341 181 µM 1.15353003567642 0.130162003946209 no 477 0.124346448338817 136 774970
SGTC_3208 9114115 49.47 µM 1.14571671017626 0.131815090610838 no 478 0.125956193704668 174 650895
SGTC_3184 9108758 49.47 µM 1.14443926916597 0.132086733869606 no 479 0.126220755229379 156 902885
SGTC_849 0386-0493 241 µM 1.14373923200628 0.132235757882299 no 480 0.126365899001835 160 726119
SGTC_3099 9120367 49.47 µM 1.14335508640442 0.132317584088273 no 481 0.12644559609144 162 24824940
SGTC_463 ikarugamyin 104 µM 1.14298999850193 0.132395383185066 no 482 0.126521371808879 116 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_293 4049-0273 38.5 µM 1.14040093121575 0.132948009846333 no 483 0.127059652552843 157 1380311
SGTC_2396 5342950 42.78 µM 1.13971435548826 0.133094822871414 no 484 0.127202662227975 200 1886677
SGTC_2343 7990716 14.84 µM 1.13791306332869 0.133480530104066 no 485 0.127578392952008 157 6456862
SGTC_1509 1326-1131 80 µM 1.13367608364692 0.134390815157703 no 486 0.128465222664384 138 768313
SGTC_95 0471-0001 561.058 µM 1.13357470095612 0.134412648601283 no 487 0.128486495066904 164 4015405
SGTC_2927 9011802 47.9 µM 1.12701090162183 0.135831391965964 no 488 0.129868935903301 141 43912568
SGTC_1671 st016596 74.5 µM 1.12684642915665 0.13586707335462 no 489 0.129903708183728 165 2829167
SGTC_71 0417-1750 47.813 µM 1.12584501365954 0.136084463394747 no 490 0.13011556357201 163 6811472
SGTC_335 4077-0256 27.6 µM 1.12179262490295 0.136966597453067 no 491 0.130975311363146 180 3121989
SGTC_2529 gangaleoidin 93.61 µM 1.11576911827053 0.138285016388513 no 492 0.13226048792967 157 4565183
SGTC_938 3126-1755 342 µM 1.11109490837806 0.139314045469732 no 493 0.133263749639891 148 1777771
SGTC_2404 5161160 200 µM 1.11069437105489 0.139402465636765 no 494 0.133349962984168 197 2831543
SGTC_2255 7941087 197.44 µM 1.110179503408 0.13951618073215 no 495 0.1334608416214 150 935561
SGTC_2665 lovastatin 100 µM 1.10987573190171 0.139583302133047 no 496 0.133526289665399 159 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_707 0865-0008 204 µM 1.10849751577514 0.139888108799878 no 497 0.133823505705408 172 723043
SGTC_746 1095-0025 46.6 µM 1.10746294122563 0.140117212636874 no 498 0.134046913089984 173 6749286
SGTC_1780 st038448 24.544 µM 1.10680826396612 0.140262320829047 no 499 0.134188417266148 152 728868 YDL195W SEC31
SGTC_871 0574-0004 149 µM 1.10665764625768 0.140295719445709 no 500 0.134220986804476 175 9551173
SGTC_2636 apigenin dimethyl ether 100 µM 1.10390697567644 0.140906614988933 no 501 0.134816746298354 163 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1610 st001799 48.1 µM 1.10349854947983 0.140997475857558 no 502 0.134905360559261 141 621897
SGTC_3328 9140624 29.0385 µM 1.1003738711217 0.141693924861062 no 503 0.135584629056403 167 4904392
SGTC_2234 tolnaftate 200 µM 1.09901961961736 0.141996492000132 no 504 0.135879754117454 151 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_600 1495-0418 41.6 µM 1.09851576776725 0.142109174236874 no 505 0.135989668148391 182 5377768
SGTC_2948 9070189 9.45 µM 1.0978066148415 0.142267872848179 no 506 0.136144471198656 138 6473636 YDL196W YDL196W
SGTC_717 1532-0246 73.2 µM 1.09704213926221 0.142439086169243 no 507 0.136311485830029 153 9561992
SGTC_2853 9015042 58.44 µM 1.09616403669636 0.142635919515199 no 508 0.136503497415542 135 6457456
SGTC_2027 5150920 200 µM 1.09591485326525 0.142691809354871 no 509 0.136558019156088 148 786715
SGTC_233 rapamycin 362 pM 1.09553439572033 0.142777171480243 no 510 0.136641292611481 168 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2414 st077232 92.9 µM 1.09538263899292 0.14281123031367 no 511 0.136674518373736 129 729801
SGTC_819 1013-0258 27.7 µM 1.09371365573546 0.143186163317658 no 512 0.137040291606386 173 5753198
SGTC_2593 nobiletin 86.24 µM 1.09316250664448 0.143310123517702 no 513 0.137161227839264 138 72344 An anti-infammatory.
SGTC_993 3909-8757 62.7 µM 1.09308855976286 0.143326760591935 no 514 0.137177459225189 143 4288324 YLR208W SEC13
SGTC_1649 st011737 51.3 µM 1.09263978853484 0.143427756181961 no 515 0.137275992929 153 1761035
SGTC_2203 7227154 166.4 µM 1.08894275623799 0.144261598414212 no 516 0.138089564962036 150 896304
SGTC_3307 9126885 69.2785 µM 1.08885457044005 0.144281527985046 no 517 0.138109011270314 145 24824909
SGTC_2817 7995342 71.43 µM 1.08705902951958 0.144687715287559 no 518 0.138505361443459 146 18879975
SGTC_734 2023-0417 80 µM 1.08409112670605 0.145360801593414 no 519 0.139162198361934 175 3935732
SGTC_210 3551-0445 56.827 µM 1.0822832437938 0.145771839405192 no 520 0.139563344593943 153 2865180 YOR207C RET1
SGTC_483 fpl-64176 144 µM 1.08107348782776 0.146047323777743 no 521 0.139832212813899 144 3423
SGTC_2596 sinensetin 100 µM 1.07731302610403 0.14690588442261 no 522 0.140670222407461 164 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2004 4023728 41.89 µM 1.07725747286867 0.14691859324674 no 523 0.140682627802591 203 360084 YDR527W RBA50
SGTC_1969 st069479 40.1 µM 1.0746176846296 0.147523343437777 no 524 0.141272965449635 165 3895485
SGTC_1498 4478-3555 97.6 µM 1.07291144961195 0.147915111609569 no 525 0.141655424194382 138 3437919
SGTC_649 1123-0311 367 µM 1.07270835956121 0.147961789403957 no 526 0.141700994230677 181 693629 YIL048W NEO1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.0722205465813 0.148073947604757 no 527 0.141810491932515 157 2374 Ca(2+)-ATPase inhibitor.
SGTC_1655 st012546 55.1 µM 1.07220938127427 0.148076515403527 no 528 0.141812998841179 152 720985 YLR208W SEC13
SGTC_2415 st077333 57.7 µM 1.0701805506175 0.148543600850151 no 529 0.142269023570711 198 2766255
SGTC_544 k015-0020 52.4 µM 1.06881424206873 0.148858712351824 no 530 0.142576690263206 177 3008304
SGTC_800 3448-7362 155 µM 1.06776596697534 0.149100778464389 no 531 0.142813046684082 206 15991913
SGTC_2919 7978188 46.38 µM 1.0605955524128 0.150763607110897 no 532 0.144436872334624 162 2980291
SGTC_3224 9130643 49.47 µM 1.06054384933648 0.1507756417852 no 533 0.144448626112432 175 17644395
SGTC_714 4296-0578 26.1 µM 1.05914266631881 0.151102031900781 no 534 0.144767405657539 181 1589775
SGTC_1121 fusaric acid 630.51 nM 1.05525546788586 0.152009971392663 no 535 0.145654250982474 154 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.05275710373113 0.152595427550534 no 536 0.146226164810062 170 2333 A French combination drug.
SGTC_1594 piperine 70.1 µM 1.05256538954587 0.152640414767484 no 537 0.146270113343791 165 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2127 5253358 187.912 µM 1.05221947473978 0.152721608611093 no 538 0.14634943324604 152 20612
SGTC_2267 7931562 200 µM 1.05104558206505 0.152997360675027 no 539 0.146618827669317 156 934880
SGTC_2607 solasodine 47.35 µM 1.05060359646386 0.153101270334662 no 540 0.146720344297955 190 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_591 4299-0174 154 µM 1.04964651143936 0.153326438796949 no 541 0.146940332163579 174 5509088
SGTC_1348 1493-0373 93.8 µM 1.04908896491825 0.153457710976493 no 542 0.147068587243006 183 3010129
SGTC_3070 9117005 49.47 µM 1.0479955517421 0.153715366979429 no 543 0.147320328165924 140 8779016
SGTC_2222 6885208 172.143 µM 1.04765153350344 0.153796491928978 no 544 0.147399592562327 167 609514
SGTC_3320 9137005 35.139 µM 1.0454103233616 0.154325698393132 no 545 0.147916683749006 184 4908713
SGTC_2770 toltrazuril 17.5 µM 1.04396122851734 0.154668506580954 no 546 0.148251664035805 167 68591 Kills coccidiodes.
SGTC_3219 9131112 49.47 µM 1.04254059950881 0.155005068783536 no 547 0.14858055630757 183 17612988 YMR079W SEC14
SGTC_17 0960-0276 49.807 µM 1.04239780435897 0.155038925210747 no 548 0.14861364201975 184 6821114
SGTC_2147 5545932 89.7195 µM 1.0412094515528 0.155320870541729 no 549 0.14888917504711 194 797404
SGTC_2594 a-mangostin 100 µM 1.03821662723074 0.156032438167987 no 550 0.149584606678217 184 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3206 9114350 49.47 µM 1.03754786042145 0.156191735977018 no 551 0.14974030139177 160 17087243
SGTC_2537 larixol 68.93 µM 1.03463475920743 0.156886875516358 no 552 0.150419757334444 179 6708759
SGTC_1652 st011932 78 µM 1.03284417710588 0.157315162217117 no 553 0.150838413038866 179 1551076
SGTC_2970 9090938 41.86 µM 1.0325734635949 0.157379980608666 no 554 0.150901775958076 185 17217104
SGTC_1047 2043-3044 82 µM 1.03235365542155 0.157432623373503 no 555 0.150953237058605 199 669592
SGTC_1085 doxorubicin 7.67 µM 1.03197028491109 0.157524466048366 no 556 0.15104301903193 197 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3022 9087993 49.47 µM 1.03178503253158 0.157568858900063 no 557 0.151086416227661 192 17173644
SGTC_1416 3966-0321 25.3 µM 1.03148914489633 0.157639780818971 no 558 0.151155748029176 175 582530 YLR208W SEC13
SGTC_2656 pseudo-anisatin 100 µM 1.03140590626884 0.157659736236891 no 559 0.151175256152911 185 6708809 A neurotoxin.
SGTC_2896 9052656 71.43 µM 1.02985709316644 0.158031347483457 no 560 0.151538547457748 204 6469436
SGTC_429 1112-0049 25.5 µM 1.02761390250594 0.158570581438698 no 561 0.152065740955796 161 2836170
SGTC_169 k015-0017 16.025 µM 1.02739883822678 0.158622343417182 no 562 0.152116349162583 192 1840002
SGTC_261 5-fluorouridine 15.376 µM 1.02608401000717 0.158939039052774 no 563 0.152425993332524 160 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1848 st056003 16.4 µM 1.02577450791604 0.159013647371015 no 564 0.152498942356343 178 146492
SGTC_1264 0783-0040 158 µM 1.0256184915461 0.159051265245988 no 565 0.152535723883853 170 2855798
SGTC_2388 9080168 200 µM 1.02454001214387 0.159311462165846 no 566 0.152790140997568 194 15943073
SGTC_945 3381-0768 11.3 µM 1.02305502574903 0.159670189964944 no 567 0.153140914835982 183 1126236 YIL048W NEO1
SGTC_1777 st045864 34.765 µM 1.0222492062861 0.159865072641228 no 568 0.153331483490125 216 4691462
SGTC_2080 5212524 12.4 µM 1.02078404523428 0.160219811650503 no 569 0.153678382538495 189 260183
SGTC_2908 7930301 100 µM 1.019820085204 0.160453482257793 no 570 0.153906897834178 191 2223178
SGTC_2768 sulfasalazine 50.2 µM 1.01650227498015 0.161259443676829 no 571 0.154695132356271 162 5384001 An antioxidant and salicylic acid derivative.
SGTC_1846 st056244 14.8 µM 1.00942962331103 0.162986329466905 no 572 0.156384318739554 172 5393182
SGTC_1170 0310-0127 64.8 µM 1.00908124747493 0.163071699783382 no 573 0.156467835312099 203 774975
SGTC_2440 5628896 157.78 µM 1.00766202116499 0.163419784846981 no 574 0.156808371684932 177 5522048
SGTC_3253 9135987 49.47 µM 1.00552535508283 0.16394474156185 no 575 0.157321973368585 190 4182430
SGTC_748 act1.228 77.9 µM 1.00446169277216 0.164206479846756 no 576 0.157578063310414 161 4421505 YNR035C ARC35
SGTC_1230 0170-0365 3.77 µM 1.00008600574185 0.165286065795909 no 577 0.158634443954715 192 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1190 1486-1332 13 µM 0.999791444485551 0.1653589056939 no 578 0.158705723522698 184 4150046
SGTC_2962 9082311 13.18 µM 0.998477505433148 0.165684072977997 no 579 0.159023933487591 191 16459453
SGTC_1706 st031321 9.9705 µM 0.997527135282161 0.165919523486965 no 580 0.159254354630855 179 6103185
SGTC_3172 9105863 49.47 µM 0.994028152328689 0.166788245574291 no 581 0.160104580910218 180 2348785
SGTC_2999 9069765 71.4286 µM 0.993479519598962 0.16692472492526 no 582 0.160238163155888 174 2097066
SGTC_2892 9047358 58.44 µM 0.992169923145469 0.167250794751486 no 583 0.160557320850162 166 6466771
SGTC_2788 5282734 71.43 µM 0.99195111595477 0.167305314453751 no 584 0.160610686131046 185 743706
SGTC_3234 9132280 49.47 µM 0.991873115421384 0.167324752442683 no 585 0.160629712622767 173 17612295
SGTC_2144 5628481 200 µM 0.991725401671135 0.167361567181909 no 586 0.160665748133559 168 2818399
SGTC_1005 4092-0690 4.4 µM 0.989220384420089 0.167986688085519 no 587 0.161277663563167 189 1529343
SGTC_2706 st078239 82.5 µM 0.987934918596116 0.168308055620613 no 588 0.161592261369985 199 15434492
SGTC_2811 7967822 32.47 µM 0.987021415417887 0.168536672376483 no 589 0.161816070089377 163 2232244
SGTC_602 3130-1533 38.1 µM 0.985113338771298 0.169014838531139 no 590 0.16228420103208 209 720941
SGTC_406 estrone 100 µM 0.984951697409859 0.169055386033936 no 591 0.162323898880837 182 5870 A steroid.
SGTC_2474 5321570 43.32 µM 0.984378488132736 0.169199225109362 no 592 0.162464725527056 182 2841384
SGTC_694 1315-0438 43.2 µM 0.982925889140104 0.169564086828819 no 593 0.162821957476637 176 6793154
SGTC_2783 7738165 71.43 µM 0.981502564367226 0.16992208473786 no 594 0.163172485225731 186 17201110
SGTC_2303 7774051 200 µM 0.980841182504014 0.170088601796901 no 595 0.163335533076685 184 2953184
SGTC_834 0312-0008 75.7 µM 0.979527576612509 0.170419640248845 no 596 0.163659684894226 178 6385573 YIL048W NEO1
SGTC_2298 7976326 193.81 µM 0.979068714463868 0.170535374102936 no 597 0.163773014322586 146 2235818
SGTC_1697 st025554 27.742 µM 0.978553362409036 0.170665415782685 no 598 0.163900356300955 185 1269519
SGTC_18 0111-0177 500 nM 0.978185478425384 0.170758284835471 no 599 0.163991298645727 191 721752
SGTC_183 3914-0051 30.55 µM 0.977008354010702 0.171055656732567 no 600 0.164282508281463 163 1596232
SGTC_604 1000-0114 314 µM 0.976684919203203 0.171137422658544 no 601 0.164362581733355 195 1572745
SGTC_2732 terfenadine 20 µM 0.974603650417626 0.171664175535057 no 602 0.16487845109208 220 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1474 0330-0125 5.35 µM 0.972223852676859 0.172267751595993 no 603 0.165469598299753 181 X1474
SGTC_2584 androsterone 48.74 µM 0.972095491222411 0.172300345703943 no 604 0.165501522501578 193 2754130 A steroid.
SGTC_2060 5238662 140 µM 0.971353460280765 0.172488842588493 no 605 0.165686147767237 191 790130
SGTC_1284 0929-0043 16 µM 0.971252777234308 0.172514429064469 no 606 0.165711209047125 191 1239883
SGTC_801 0866-0028 10.1 µM 0.97002621114801 0.172826329341156 no 607 0.166016713603687 188 6849771
SGTC_3001 9076041 71.4286 µM 0.968309560757026 0.173263454934948 no 608 0.166444895667436 187 16004211
SGTC_356 1634-0012 32.5 µM 0.967581831626687 0.173448975214214 no 609 0.166626627278692 213 735457
SGTC_1053 3366-3204 134 µM 0.967083694105862 0.173576038480361 no 610 0.166751098099102 198 3632071 YPR165W RHO1
SGTC_3053 9095903 49.47 µM 0.966464753069152 0.173733998404836 no 611 0.166905837942716 238 17174018
SGTC_3290 9121031 71.43 µM 0.96367014097244 0.17444834935027 no 612 0.167605664442624 190 17014854
SGTC_42 0133-0086 60.653 µM 0.963490955677573 0.174494215756047 no 613 0.167650600393742 232 162923 Model of phenazepam hydroxylation.
SGTC_1835 st008666 49.2 µM 0.962996570789567 0.17462080412541 no 614 0.167774622091436 158 690455
SGTC_430 0958-0115 16.4 µM 0.962377309589571 0.174779449601557 no 615 0.167930053657917 186 6833180
SGTC_2958 9077254 16.72 µM 0.961055672735141 0.175118339118488 no 616 0.168262088013835 191 16457351
SGTC_793 0488-0545 106 µM 0.959157781500716 0.17560571827227 no 617 0.16873963266388 206 292548
SGTC_815 1582-0027 36.9 µM 0.958273407562118 0.175833119122019 no 618 0.168962454753627 211 3128206
SGTC_2358 9037157 4 µM 0.956969104611871 0.176168837382935 no 619 0.169291424656244 208 2388925
SGTC_2184 6075246 200 µM 0.956586648034842 0.176267355847797 no 620 0.169387965351957 198 2267320
SGTC_2614 arthonioic acid 13.39 µM 0.954350219672092 0.176844143862622 no 621 0.169953197696559 181 6710684
SGTC_786 4544-0069 423 µM 0.954159502665972 0.176893386041866 no 622 0.17000145518336 199 748821 YLR208W SEC13
SGTC_3089 9117425 49.47 µM 0.953016128635381 0.177188781187873 no 623 0.170290949436811 175 9401657
SGTC_1458 k015-0034 6.33 µM 0.951235669140132 0.177649389781276 no 624 0.170742377641061 177 3598957
SGTC_2624 nerol 100 µM 0.950829416459165 0.177754593971187 no 625 0.170845488566045 209 637566 A natural product oil.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.949371307061966 0.178132513163379 no 626 0.171215899140679 205 390807
SGTC_84 0443-0269 128.823 µM 0.944861739049587 0.179304525310189 no 627 0.172364733571468 191 6150058
SGTC_3332 9141069 11.198 µM 0.943803773350195 0.17958018550598 no 628 0.172634966011104 190 17332883
SGTC_222 nsc-310342 10.666 µM 0.939944238877521 0.180588070066161 no 629 0.173623081840684 186 432556
SGTC_1133 3473-0247 50 µM 0.939428818303064 0.180722935766972 no 630 0.17375531137335 201 711311
SGTC_3268 9137683 49.47 µM 0.934842467576205 0.181925786477466 no 631 0.174934745078826 257 1953228
SGTC_1486 3970-0793 4.53 µM 0.934570018113175 0.181997398312271 no 632 0.175004968137366 214 2844330
SGTC_2700 st077718 96.8 µM 0.934250494667059 0.182081405737095 no 633 0.175087347162695 190 904970
SGTC_1424 4048-1941 275 µM 0.931344465182433 0.182846556213191 no 634 0.175837703974156 199 X1424
SGTC_2658 polymyxin b sulfate 77.05 µM 0.927688522025847 0.183812003059533 no 635 0.176784582033411 206 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1738 st035555 74 µM 0.925920147456565 0.184280125615225 no 636 0.177243740040195 204 5331140
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.924341623335778 0.184698617203929 no 637 0.17765423902794 198 688662
SGTC_1396 3511-0007 98.6 µM 0.92429420765787 0.184711196980295 no 638 0.177666578862282 201 X1396
SGTC_2246 7293507 91.5585 µM 0.924152375648705 0.18474882937955 no 639 0.177703493584349 208 887656
SGTC_1427 4048-4900 550 nM 0.922030001858036 0.185312529663695 no 640 0.178256463291823 221 24132586
SGTC_2369 9071472 200 µM 0.921191620279229 0.18553549687655 no 641 0.178475196237664 196 17296037
SGTC_2302 7771753 200 µM 0.920456457487416 0.185731150043804 no 642 0.178667138568796 223 2203047
SGTC_3144 9087057 49.47 µM 0.918606158214335 0.186224147175322 no 643 0.179150804868702 180 17249618
SGTC_1988 st071872 53.4 µM 0.918262695514615 0.186315749162296 no 644 0.179240676208047 185 16414116
SGTC_153 4077-0274 519.67 µM 0.915706366339019 0.18699840257137 no 645 0.179910462504597 220 3121976
SGTC_2885 9057732 51.95 µM 0.912123920531209 0.187957674627967 no 646 0.180851743742892 231 6471414
SGTC_3110 9122132 49.47 µM 0.910597803627632 0.188367244319577 no 647 0.18125366410173 177 918317
SGTC_1906 st060206 94.7 µM 0.908434005304367 0.188948893743688 no 648 0.181824483164826 221 5133468
SGTC_957 1187-1561 14.1 µM 0.90561140240074 0.18970929711292 no 649 0.182570785705857 215 1538454
SGTC_281 1672-3440 14.9 µM 0.904523223785874 0.190002952155969 no 650 0.182859012779399 202 6833000
SGTC_2560 caryophyllene 100 µM 0.901864187262353 0.190721692359449 no 651 0.183564508781578 227 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2699 st077704 54.6 µM 0.90144772794257 0.190834412666545 no 652 0.18367515728242 191 645852
SGTC_2993 9054257 71.4286 µM 0.899489021705786 0.191365110820874 no 653 0.184196120396287 228 6470217 YGL055W OLE1
SGTC_1076 itraconazole 331 nM 0.89946897591442 0.191370546763319 no 654 0.184201456786621 205 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2879 9041815 71.43 µM 0.891697437974494 0.193485128115804 no 655 0.18627756358082 164 4942971
SGTC_2300 7976697 71.57 µM 0.890926253737565 0.193695736528276 no 656 0.186484367348587 179 2236109
SGTC_1404 3909-7820 48.3 µM 0.889655781127626 0.19404300397419 no 657 0.186825372181185 203 23741373
SGTC_913 3487-1245 167 µM 0.889191462424493 0.194170014146034 no 658 0.186950095202854 213 4016153
SGTC_1138 3761-0006 1.03 µM 0.887731680970576 0.19456965386174 no 659 0.18734255004561 194 12061087
SGTC_2167 5876490 200 µM 0.886847500857675 0.19481195626313 no 660 0.187580504869556 215 686534
SGTC_1445 4239-0156 97.7 µM 0.885970960103424 0.195052346231293 no 661 0.187816588001703 218 4008346
SGTC_81 0411-0046 9.971 µM 0.885922776809577 0.195065565652884 no 662 0.18782957076919 228 12925265
SGTC_1235 benzylparaben 21.5 µM 0.884867958433785 0.1953550988568 no 663 0.188113925597484 221 7180
SGTC_1431 4049-0260 9.09 µM 0.884462137879082 0.195466560550948 no 664 0.188223396241266 230 3854841
SGTC_863 0466-0191 129 µM 0.884093104782496 0.19556795181486 no 665 0.188322977535935 225 765160 YPR165W RHO1
SGTC_1201 1889-3372 45.9 µM 0.883861811249601 0.195631515627116 no 666 0.188385407228351 210 5392199
SGTC_226 1,3-diallylurea 8.28947 mM 0.880842352860553 0.196462469790741 no 667 0.189201576306591 207 74537 YKL182W FAS1
SGTC_2895 9054447 58.44 µM 0.877075875240661 0.197501996367895 no 668 0.190222713617324 227 2697450
SGTC_2682 pyrogallin 40.03 µM 0.876945338727727 0.197538083233606 no 669 0.190258164233858 202 822798 An ATP competetive kinase inhibitor.
SGTC_2926 9010726 65.15 µM 0.875786537872974 0.197858608876061 no 670 0.190573044931179 206 2994293
SGTC_2085 5307070 144.047 µM 0.875318589912184 0.197988132825921 no 671 0.190700290955698 229 2840351
SGTC_496 calpeptin 138 µM 0.875165230439776 0.198030592540998 no 672 0.190742004335021 204 73364 A calpain inhibitor.
SGTC_2428 5615643 7.78 µM 0.872833951655301 0.198676716614738 no 673 0.191376795455907 229 2253075
SGTC_80 0159-0065 512.242 µM 0.871193170019415 0.199132227696918 no 674 0.191824344277055 205 1548079
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.870519913148512 0.199319318048496 no 675 0.19200817086225 191 6708561
SGTC_550 4123-0385 25.7 µM 0.869808252479526 0.199517195405345 no 676 0.192202600415909 206 5731123
SGTC_3122 9126309 49.47 µM 0.867708892230562 0.200101611329333 no 677 0.192776858332353 254 17591206
SGTC_3033 9090887 49.47 µM 0.867235384289374 0.200233567650038 no 678 0.192906526183911 206 19325384
SGTC_1418 3966-3099 2.4 µM 0.865755717384223 0.200646255384597 no 679 0.193312068998066 224 740335
SGTC_1001 4048-4355 44.4 µM 0.865136110233927 0.20081921901232 no 680 0.193482043561088 219 21824233
SGTC_256 clotrimazole 625 nM 0.864586961460814 0.200972588921214 no 681 0.193632765717723 210 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_334 1502-1024 68.5 µM 0.863609948975208 0.201245629106103 no 682 0.193901098468589 204 3296216
SGTC_2742 clothiapine 36.27 µM 0.862110694774301 0.201665049484448 no 683 0.194313303361815 180 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1056 3448-1962 115 µM 0.862015552184648 0.201691683534603 no 684 0.194339479853977 215 715507
SGTC_1915 st067105 30.6 µM 0.861490652650517 0.201838660863054 no 685 0.194483933568251 226 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1940 st075990 51.1 µM 0.859797146823799 0.202313297139949 no 686 0.19495043616542 234 1084979
SGTC_1065 prochlorperazine maleate 2.48 µM 0.859307301561175 0.202450709692607 no 687 0.195085498444934 244 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2736 butenafine 14.65 µM 0.858469151518706 0.202685958917425 no 688 0.195316728725383 217 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1142 3253-1408 9.78 µM 0.858440640457275 0.202693964181255 no 689 0.195324597333559 221 256655
SGTC_2052 5265182 7.135 µM 0.857955955842632 0.202830081609083 no 690 0.195458392190034 216 1239884
SGTC_1152 3909-8331 15.9 µM 0.857366596777994 0.202995669057493 no 691 0.195621156897559 207 16001939
SGTC_1050 3232-1156 69.3 µM 0.857246671946007 0.203029373249394 no 692 0.195654286899681 232 700529
SGTC_218 alverine citrate 93.75 µM 0.857132748102492 0.203061393992355 no 693 0.19568576224506 220 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.857112697625146 0.203067029921675 no 694 0.195691302191025 207 71034 A hepatoprotective.
SGTC_1000 4048-0884 8.67 µM 0.855645435445107 0.20347971174955 no 695 0.196096965030826 220 13040088
SGTC_1696 st025591 34.7925 µM 0.854613940400172 0.203770129058583 no 696 0.196382453771772 205 2787147
SGTC_2372 9071633 200 µM 0.853535776202825 0.204073950023656 no 697 0.196681128339504 211 21321366
SGTC_2210 7115885 190.385 µM 0.847466268675269 0.2057893344516 no 698 0.198367640383905 222 2927039
SGTC_2807 7945238 51.95 µM 0.846343594154671 0.206107563529802 no 699 0.198680547550116 224 17148797
SGTC_3241 9133421 49.47 µM 0.845895367800275 0.206234697538003 no 700 0.198805558425493 256 17018221
SGTC_557 1315-0110 16.2 µM 0.844357546100106 0.206671235337413 no 701 0.199234819066053 220 6833801
SGTC_3267 9137951 49.47 µM 0.843750296023284 0.206843764558924 no 702 0.199404477744671 229 16643986
SGTC_3249 9135183 49.47 µM 0.842243569815788 0.207272217015259 no 703 0.199825815182046 217 4902779
SGTC_1963 st076565 50.3 µM 0.841508866260169 0.207481327421473 no 704 0.200031460056178 243 4914280
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.841395229017171 0.20751368184235 no 705 0.200063278686844 204 5379071
SGTC_1255 0566-0045 221 µM 0.837460979252874 0.208635666050384 no 706 0.201166750840567 222 2788469
SGTC_2317 5986382 200 µM 0.836028070107704 0.209045195226637 no 707 0.201569555917688 245 877883
SGTC_1850 st056238 17 µM 0.835544189198308 0.209183596507737 no 708 0.201705688741944 240 5393177
SGTC_2171 5739187 198.077 µM 0.83370656124913 0.209709692387026 no 709 0.202223179945218 220 2262761
SGTC_1128 3448-9350 235 µM 0.831649805796547 0.210299444154865 no 710 0.202803320222222 212 619386
SGTC_1141 3253-0389 52.6 µM 0.828728948331302 0.2111386389658 no 711 0.203628900627113 238 5402031
SGTC_996 3970-0799 1.8 µM 0.826350522239701 0.211823434612579 no 712 0.204302640861448 250 6615648 YGL040C HEM2
SGTC_59 0330-0160 1.33 µM 0.825553033008138 0.212053338038134 no 713 0.204528843588766 220 4293482
SGTC_1561 5-methoxyflavone 52.9 µM 0.825180018920788 0.212160922117723 no 714 0.204634697791402 218 94525
SGTC_2100 5377183 190 µM 0.824984071696531 0.21221744965995 no 715 0.20469031688957 217 2844202
SGTC_949 1165-0505 146 µM 0.824448445564844 0.212372013882118 no 716 0.204842398823029 233 6244267
SGTC_1067 clotrimazole 1.36 µM 0.823669663868898 0.212596862178124 no 717 0.205063640478144 224 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1892 st058411 7.36 µM 0.82099580745976 0.213369910031152 no 718 0.205824328156112 241 3934738
SGTC_1439 4092-1168 46 µM 0.820598800510722 0.213484829633929 no 719 0.205937415575435 240 2886240
SGTC_1507 4075-3230 155 µM 0.819372715986071 0.213839965794407 no 720 0.206286898317652 223 659771
SGTC_1225 1216-0074 20.6 µM 0.814457568627333 0.215267090773004 no 721 0.207691435290338 237 4241466
SGTC_581 0958-0271 211 µM 0.813818510983459 0.215453047898738 no 722 0.207874464498389 230 4591145
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.812854914872811 0.215733617433722 no 723 0.208150623110956 240 364106
SGTC_3169 9102970 49.47 µM 0.811878875523957 0.216018025856582 no 724 0.208430568450763 236 17027839
SGTC_2466 5983409 37.09 µM 0.810816140430422 0.216327943438959 no 725 0.208735632027192 219 2879657
SGTC_76 0433-0009 400.328 µM 0.810041869653664 0.216553900283369 no 726 0.208958056039441 221 2841569
SGTC_1184 1269-1718 139 µM 0.809038686611584 0.216846863979912 no 727 0.209246446978599 228 5403821
SGTC_2059 5238311 157 µM 0.808965606948425 0.216868214686782 no 728 0.209267464771337 246 703021
SGTC_68 0986-0284 82.829 µM 0.808246860736048 0.217078265890062 no 729 0.209474243186342 238 423278 YIL048W NEO1
SGTC_1513 0337-0559 19 µM 0.807723177919695 0.217231384462756 no 730 0.209624978853749 231 775073
SGTC_548 1436-0017 110 µM 0.807280339689553 0.217360913715712 no 731 0.209752494165951 214 9677137
SGTC_747 3448-8087 38.7 µM 0.806977997254655 0.217449373855845 no 732 0.209839579891405 235 5168703
SGTC_3121 9125696 49.47 µM 0.805883608089445 0.217769746816362 no 733 0.21015498181588 260 1235365
SGTC_1013 4112-3890 241 µM 0.805871577759907 0.217773270103613 no 734 0.210158450492147 250 705171
SGTC_1199 1638-0010 4.46 µM 0.805766290215809 0.217804106760352 no 735 0.210188809234037 232 3111136
SGTC_1372 2752-0194 270 µM 0.805283260851915 0.217945608865973 no 736 0.210328119535264 228 823334
SGTC_3343 9148379 18.9835 µM 0.80275527892328 0.218687038265622 no 737 0.211058097600621 234 1955036
SGTC_2570 licareol 100 µM 0.802426060210962 0.218783701234798 no 738 0.211153271704121 231 443158
SGTC_394 menadione 8.33 µM 0.801732275181092 0.218987486179003 no 739 0.211353920906457 244 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_575 k072-0246 11.9 µM 0.799841051549095 0.219543547937096 no 740 0.211901447534456 234 6796779
SGTC_975 1335-0046 28.5 µM 0.798045246289905 0.220072304445909 no 741 0.212422116862542 249 16486740
SGTC_3329 9141233 27.5565 µM 0.797345904936479 0.220278415834529 no 742 0.212625083437911 236 4909101 YNL103W MET4
SGTC_802 4112-3352 742 µM 0.792716612108189 0.221645559109685 no 743 0.213971474744123 218 704594
SGTC_2945 9067681 61.76 µM 0.792542747386185 0.221696999907404 no 744 0.214022138364124 284 16456930
SGTC_1657 st012939 43.4 µM 0.792173371654935 0.221806308557661 no 745 0.214129796434029 233 24207257
SGTC_856 0433-0016 11.3 µM 0.7920722241077 0.221836246325378 no 746 0.214159282343899 239 3911780
SGTC_1705 st027868 56.3335 µM 0.791977584369117 0.221864259994289 no 747 0.214186873276771 236 292948
SGTC_986 1493-0483 84 µM 0.791399610147791 0.222035386075628 no 748 0.214355418704123 239 40079
SGTC_1283 0922-0125 16.4 µM 0.790319030669622 0.222355525113722 no 749 0.214670737742438 220 3360884
SGTC_2152 5568786 200 µM 0.78951544672868 0.222593770391714 no 750 0.214905402629408 251 5399883
SGTC_230 MPP+ 141.667 µM 0.788950967589613 0.222761213245962 no 751 0.215070332500909 244 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_508 roscovitine 141 µM 0.788389109118179 0.222927949982603 no 752 0.21523456962056 264 160355 A CDKinase inhibitor.
SGTC_3154 9100113 49.47 µM 0.787607600590033 0.223159988091799 no 753 0.215463133747919 235 25237525
SGTC_2150 5556613 200 µM 0.786938633509532 0.223358720639724 no 754 0.215658895198907 247 743190
SGTC_2900 5328528 85.29 µM 0.786716181697521 0.223424827535345 no 755 0.215724014649463 249 795359
SGTC_2285 7945142 200 µM 0.786651242190811 0.223444127967489 no 756 0.215743026870901 250 2970608
SGTC_1279 0874-0590 65.2 µM 0.786561155867077 0.223470903763249 no 757 0.21576940288852 240 3523074
SGTC_515 4092-1064 102 µM 0.786330817718862 0.223539374032861 no 758 0.21583685118051 258 717353
SGTC_3243 9134147 49.47 µM 0.786016568613909 0.223632806897673 no 759 0.215928890228951 254 24282180
SGTC_2508 celastrol 40.54 µM 0.785331508183415 0.223836566719121 no 760 0.21612961339313 214 122724 Celastrol is a natural product and antioxidant.
SGTC_825 1988-2224 89.6 µM 0.783200063947417 0.22447120375968 no 761 0.216754818680963 241 1180859
SGTC_2484 5809818 12.04 µM 0.782994007851701 0.224532610997055 no 762 0.216815315417577 225 2870548
SGTC_1877 wortmannin 25 µM 0.782589373424711 0.224653224737941 no 763 0.216934141871559 243 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1886 st057356 49.9 µM 0.782358288045336 0.224722123329193 no 764 0.217002020149302 221 24207747
SGTC_1730 st033808 45.1 µM 0.781611735724608 0.224944791345597 no 765 0.217221393895954 243 1045166
SGTC_383 2324-0395 7.37 µM 0.781372437669847 0.225016191264964 no 766 0.217291738521949 233 3146421
SGTC_3000 9075062 71.4286 µM 0.781227486004297 0.225059447077162 no 767 0.217334355256121 242 17057871
SGTC_2099 5377090 177.372 µM 0.780755812603037 0.225200234300202 no 768 0.217473063711159 242 2243829
SGTC_627 1391-0720 175 µM 0.779979543579095 0.225432047187617 no 769 0.217701458061328 271 997839
SGTC_1413 3910-0535 34.4 µM 0.779555793416392 0.225558646310296 no 770 0.217826192463996 240 2876951
SGTC_3152 9099253 49.47 µM 0.779409380219892 0.225602397903519 no 771 0.217869299992294 252 25236131
SGTC_1202 1988-0068 29.6 µM 0.777519634340679 0.226167527771596 no 772 0.218426127525718 240 2850480
SGTC_2857 9024691 58.44 µM 0.776385235821388 0.22650715433608 no 773 0.218760779715442 239 16478292
SGTC_2916 7875993 68.79 µM 0.775625009226352 0.226734918952406 no 774 0.218985214690611 271 1299250
SGTC_2475 5812728 15.03 µM 0.775103919238252 0.226891112633885 no 775 0.219139127948738 246 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2875 9039966 71.43 µM 0.774361397626546 0.227113783972688 no 776 0.219358552422127 246 6463691
SGTC_561 1550-0330 72.9 µM 0.77309556189659 0.227493673415578 no 777 0.219732913731503 238 6812934
SGTC_2907 7721985 69.9 µM 0.771962265070346 0.227834090081256 no 778 0.220068388649455 237 3267881
SGTC_3143 9086658 49.47 µM 0.771296345165743 0.228034250944151 no 779 0.220265649105418 247 25236626
SGTC_306 1672-3436 11.6 µM 0.770592092322689 0.228246041409824 no 780 0.220474374901052 254 6797378
SGTC_106 0092-0003 11.579 µM 0.769063846227476 0.2287060120658 no 781 0.220927704698303 233 1072148
SGTC_2796 7949634 45.45 µM 0.76644608397542 0.229495112664079 no 782 0.221705460531533 264 2971588
SGTC_1558 st069300 45.6 µM 0.766301455338073 0.229538754078826 no 783 0.221748476285694 242 24208000
SGTC_1341 1486-1360 280 µM 0.765449126927661 0.229796036972634 no 784 0.222002074424713 268 3976547
SGTC_657 3534-0529 86.7 µM 0.764476853557504 0.230089723373242 no 785 0.222291562548265 247 1049549
SGTC_955 1216-0110 33 µM 0.763979622144538 0.23023999898991 no 786 0.222439693190193 247 3619719
SGTC_3348 9149464 3.537 µM 0.762922039995558 0.230559808914244 no 787 0.222754945547305 235 1951442
SGTC_1619 st003326 88.7 µM 0.761131498552052 0.231101829228974 no 788 0.223289264178016 221 2849032
SGTC_2453 5731132 22.18 µM 0.760919859031353 0.231165942240515 no 789 0.223352468069758 261 1362040
SGTC_1527 coumarin 137 µM 0.760885247050909 0.2311764283639 no 790 0.223362805538089 264 323 A hepatotoxic, DNA x-linker.
SGTC_2917 7979103 53.79 µM 0.760869834313947 0.231181097926736 no 791 0.223367408906938 225 2980565
SGTC_2218 6965428 192.983 µM 0.760703359540103 0.231231537774808 no 792 0.22341713387253 238 675684
SGTC_1682 st012968 530 nM 0.758617481073251 0.231864053933106 no 793 0.224040706215473 223 24207270
SGTC_2355 9061122 103.12 µM 0.757924180654401 0.23207450167401 no 794 0.224248186753348 257 5302957
SGTC_1484 3473-2379 286 µM 0.757287023095097 0.232268001269876 no 795 0.224438961864618 244 671917
SGTC_2820 7989630 71.43 µM 0.756537233018403 0.23249582137978 no 796 0.224663578867324 194 2984098
SGTC_1746 st038117 42 µM 0.755556594924122 0.23279397099664 no 797 0.224957544086424 242 2898218
SGTC_556 4058-0063 51.5 µM 0.751633783363648 0.233988770494307 no 798 0.226135660574579 246 6615692
SGTC_1864 st057645 30.4 µM 0.751315041219816 0.234086001122584 no 799 0.226231539578255 260 688666
SGTC_1954 st077032 68.9 µM 0.749084868314271 0.234766929329884 no 800 0.226903027338083 283 698907
SGTC_2281 7943571 200 µM 0.748289412488682 0.23501006679359 no 801 0.227142804632827 259 1244024
SGTC_3147 9097027 49.47 µM 0.74774819483652 0.235175573812529 no 802 0.227306027558495 280 25236841
SGTC_1764 st044502 93.5 µM 0.746264797926734 0.235629533699573 no 803 0.227753735910108 241 8407
SGTC_469 w7 172 µM 0.745588759214681 0.23583658019654 no 804 0.227957937648649 243 45115570 A P450 inhibitor.
SGTC_225 nsc-122657 1.016 µM 0.743989317074983 0.236326831276111 no 805 0.22844146904502 251 275685
SGTC_118 0083-0097 135.343 µM 0.743265540969647 0.236548862908431 no 806 0.228660464872762 292 5207356
SGTC_2511 berberine 10.47 µM 0.743121998686879 0.236592910779651 no 807 0.228703911039345 268 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1108 betulinic acid 729.144 nM 0.737977535100413 0.23817453386456 no 808 0.230264050312368 233 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_157 1348-1695 65.819 µM 0.737181027073905 0.238419930589869 no 809 0.23050613486673 250 5380510
SGTC_2202 7226349 200 µM 0.736969992431012 0.238484971595566 no 810 0.230570298950847 233 844334
SGTC_57 miconazole 162.5 nM 0.736455740008493 0.238643505174563 no 811 0.230726696753337 249 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1893 st059353 36.1 µM 0.735612657197232 0.238903535215551 no 812 0.230983228767825 277 3112488
SGTC_779 1360-0071 233 µM 0.73473410694178 0.239174669174266 no 813 0.231250722092927 257 7566
SGTC_3064 1327-0027 10 µM 0.734548309094959 0.239232030746986 no 814 0.231307314331691 241 16000455 YPR107C YTH1
SGTC_110 0850-0284 111.64 µM 0.733758002566842 0.239476106912845 no 815 0.231548120398418 238 3906265
SGTC_2952 9073731 13.78 µM 0.733590091506826 0.23952798162606 no 816 0.231599300821496 270 16457353
SGTC_673 1082-0474 110 µM 0.732435850919637 0.239884740552475 no 817 0.23195129172733 275 3098046
SGTC_826 1683-5028 118 µM 0.731218265173557 0.240261392453044 no 818 0.232322922679254 256 722377
SGTC_654 1124-0271 80.9 µM 0.730477370899561 0.240490740685037 no 819 0.232549220093086 257 5403748
SGTC_3020 9089140 49.47 µM 0.725538794623173 0.242022547966806 no 820 0.234060777011419 254 17217859
SGTC_2195 6536160 144.242 µM 0.721205474930299 0.243370968182234 no 821 0.235391551895388 250 3834386
SGTC_876 0720-0963 56.8 µM 0.720385622822258 0.243626541484914 no 822 0.235643799789213 259 765861
SGTC_2028 5153890 36.43 µM 0.71789726327204 0.244403126943124 no 823 0.236410317720564 268 2830968 YPR165W RHO1
SGTC_2561 acetosyringone 100 µM 0.717769457841739 0.244443049381193 no 824 0.236449724116296 287 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_309 k408-0051 1.48 µM 0.716794416866048 0.244747737454011 no 825 0.236750478597608 268 3640463
SGTC_919 tnp00227 403.569 nM 0.716686974873201 0.244781324230654 no 826 0.236783632285349 278 1269246 A methoxyflavone. YNL221C POP1
SGTC_424 splitomicin 100 mM 0.713743841381194 0.245702323096973 no 827 0.237692795704308 278 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1934 st074720 32.6 µM 0.713710238470578 0.245712849235513 no 828 0.237703187026069 264 17250992
SGTC_2272 7805186 180 µM 0.713646012210062 0.245732968836492 no 829 0.237723048967363 290 2956062 YPR165W RHO1
SGTC_2822 7994718 71.43 µM 0.713283214663944 0.245846635870925 no 830 0.237835261034918 300 1018011
SGTC_316 k060-0003 58.6 µM 0.713280970375943 0.245847339110031 no 831 0.23783595527608 264 6152314
SGTC_212 3807-4682 38.772 µM 0.712255506948808 0.246168777101444 no 832 0.238153285223968 266 3125501 YBL034C STU1
SGTC_613 3914-0030 117 µM 0.711888893182119 0.246283749171024 no 833 0.238266790230008 250 1145395
SGTC_1461 k072-0203 53.8 µM 0.711408870458377 0.246434330417918 no 834 0.238415451868425 269 5418714
SGTC_2079 5212404 121 µM 0.711295497883425 0.246469902151353 no 835 0.238450570437363 252 758462
SGTC_1162 k048-0130 20.1 µM 0.710779021188521 0.246631986481365 no 836 0.238610591369962 264 6797406
SGTC_2103 5378138 10 µM 0.70958921458436 0.247005597057288 no 837 0.238979454905149 267 244142
SGTC_1115 galangin 695.678 nM 0.709243939417898 0.247114073400531 no 838 0.239086555358193 285 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3 0833-0587 95.581 µM 0.708778320873391 0.2472603987986 no 839 0.239231026502735 260 5382644
SGTC_1878 temozolomide 1 mM 0.705819779611767 0.248191232064147 no 840 0.240150109949677 258 5394 DNA alkylating agent.
SGTC_132 0417-1715 25.805 µM 0.70571507255397 0.248224209806542 no 841 0.240182672867864 269 6769098
SGTC_3075 9116269 49.47 µM 0.704648177303473 0.248560364219198 no 842 0.240514604478416 270 17015205 YNL244C SUI1
SGTC_1931 st074438 57.1 µM 0.704122780870548 0.248725993759566 no 843 0.240678157151404 296 2787313
SGTC_1722 st034304 3.6505 µM 0.700280163044442 0.249939151406065 no 844 0.241876178789275 275 4036148 YLR033W RSC58
SGTC_872 0588-0139 234 µM 0.700091258520568 0.249998871567692 no 845 0.241935157301263 253 2047100
SGTC_1707 st032323 6.317 µM 0.699499537500847 0.250185986887071 no 846 0.242119950976396 260 3132057 YMR211W DML1
SGTC_570 0987-0065 62.6 µM 0.699494178720699 0.250187681791601 no 847 0.242121624865803 259 3104428
SGTC_2933 9026794 32.47 µM 0.698334271770491 0.250554686822937 no 848 0.242484085530251 264 17586027
SGTC_3130 9127414 49.47 µM 0.697891195318106 0.250694955464302 no 849 0.242622620544223 274 1494646
SGTC_2023 5144124 124 µM 0.695628202032105 0.251412019465485 no 850 0.243330849904856 273 2830192
SGTC_8 0354-0001 70 µM 0.695374029549789 0.251492625562254 no 851 0.243410465792397 257 4993152
SGTC_2208 7283366 200 µM 0.691334297374835 0.252775583006511 no 852 0.244677741535313 273 898663
SGTC_959 1222-0044 107 µM 0.690928318929412 0.252904705867595 no 853 0.244805294321567 268 6083612
SGTC_749 1000-0129 128 µM 0.690661446445765 0.252989604499106 no 854 0.244889161441038 270 708470
SGTC_1499 4480-0877 67.3 µM 0.68844587908332 0.253695009039862 no 855 0.245586020394425 266 2861909
SGTC_2630 antimycin a 100 µM 0.687209159628819 0.254089211312387 no 856 0.245975466558074 287 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1711 st032263 62.8 µM 0.686672838425597 0.254260262634003 no 857 0.246144458449446 286 3958979
SGTC_799 1310-0557 151 µM 0.685427124303241 0.254657796664294 no 858 0.246537216345245 285 5354492
SGTC_1321 1326-2144 215 µM 0.685395727099792 0.254667820387471 no 859 0.246547119821995 283 3513030
SGTC_1046 2001-0062 216 µM 0.685328315053598 0.254689342737633 no 860 0.246568384016426 282 739778
SGTC_1468 k284-1086 134 µM 0.684222642312678 0.255042481936058 no 861 0.246917293299892 271 15996457
SGTC_2485 5633444 17.78 µM 0.683862530156615 0.255157552904842 no 862 0.247030988349595 265 5724239
SGTC_495 decylubiquinone 155 µM 0.682936599335913 0.255453551327523 no 863 0.24732345290739 289 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.682462609551919 0.255605144175395 no 864 0.247473238944354 274 521171
SGTC_2703 st077852 53.4 µM 0.682148224778397 0.255705717576402 no 865 0.247572614757204 288 6281836
SGTC_304 1310-0298 97 µM 0.681809070959174 0.25581423789407 no 866 0.247679843868744 298 1550234
SGTC_2005 4024620 188 µM 0.681255064439638 0.255991557128903 no 867 0.247855055564888 281 236743
SGTC_1739 st037196 92.5 µM 0.680011124778365 0.256389934741643 no 868 0.248248708440962 281 612214
SGTC_2657 nystatin 74.44 µM 0.679564176370418 0.256533150955336 no 869 0.248390229567044 265 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1436 4092-1007 8.32 µM 0.675912325044312 0.25770487739623 no 870 0.24954815600235 252 2881121
SGTC_1362 1611-0397 101 µM 0.675897854692013 0.257709525847689 no 871 0.249552749949081 275 27816
SGTC_1804 st050076 49.1 µM 0.675391531881593 0.257872204233292 no 872 0.249713522078359 279 3895976
SGTC_1444 4112-3581 28 µM 0.674866044192056 0.258041096507045 no 873 0.249880437759935 277 2877249
SGTC_1570 verbenone 133 µM 0.674271420012102 0.258232278482772 no 874 0.250069385325794 283 29025 A natural terpanoid with antifungal properties.
SGTC_1257 0669-0121 16 µM 0.674172758938644 0.258264006827525 no 875 0.250100743163103 284 4307855
SGTC_1217 1183-1422 255 µM 0.673535028228722 0.258469142924912 no 876 0.250303485932981 270 2849664
SGTC_31 0508-1974 57.237 µM 0.673360633898478 0.258525254292048 no 877 0.250358943295156 255 6810525
SGTC_204 PMA1.184 62.41 µM 0.670355326071602 0.259493202117824 no 878 0.251315652962631 283 2252213 YGL008C PMA1
SGTC_2876 9059903 25.97 µM 0.668568576512709 0.260069563283634 no 879 0.251885361618727 272 6916095
SGTC_2280 7785178 200 µM 0.667819226925135 0.260311481206138 no 880 0.252124495967417 279 2954328
SGTC_1011 4112-3381 17.4 µM 0.667566489336152 0.260393100440061 no 881 0.252205177228343 292 2877139
SGTC_2163 5671233 125 µM 0.666092196714002 0.26086947199459 no 882 0.252676085962879 274 701023
SGTC_2412 st077135 33.4 µM 0.664930192061768 0.261245253102016 no 883 0.253047571822898 304 13258915
SGTC_3349 9149703 23.001 µM 0.663784267975803 0.261616106098755 no 884 0.253414198031611 273 4910494
SGTC_1914 st062367 72.6 µM 0.663216195470583 0.261800050326912 no 885 0.253596050226499 293 978205
SGTC_1635 st007035 42.4 µM 0.661665936090538 0.262302368072435 no 886 0.254092670087216 270 3716403
SGTC_715 0868-0130 184 µM 0.6566011853881 0.263946891359416 no 887 0.255718693245835 294 2876258
SGTC_2455 5377712 9.75 µM 0.655372317214081 0.264346695305955 no 888 0.256114035146977 261 2243908
SGTC_712 r015-0009 80.6 µM 0.653025469556197 0.265111081970684 no 889 0.256869929426061 293 6813872 YLR060W FRS1
SGTC_1496 4469-0713 57.4 µM 0.651326473642023 0.265665157964972 no 890 0.257417881247247 298 746691
SGTC_667 1498-1044 59 µM 0.651036782440589 0.265759690527674 no 891 0.257511371599027 300 6739982
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.650686229407284 0.265874106432291 no 892 0.257624527114592 299 4620898
SGTC_3123 9126162 49.47 µM 0.648571484886867 0.26656486035225 no 893 0.258307695811534 272 25239884
SGTC_1475 4092-1048 11.7 µM 0.648308919497301 0.266650687228661 no 894 0.2583925830926 295 2881759
SGTC_3203 9113543 49.47 µM 0.647549146862124 0.266899118944434 no 895 0.258638298665947 279 17018012
SGTC_3063 1327-0034 4 µM 0.646929929138038 0.267101678229039 no 896 0.25883864727486 293 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2606 farnesol 9.78 µM 0.646863975523368 0.267123257631575 no 897 0.258859991374118 301 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_928 2764-0428 58.7 µM 0.645066166050967 0.267711822766903 no 898 0.259442154209798 292 662578
SGTC_2838 9002687 71.43 µM 0.644350960788591 0.267946147547006 no 899 0.259673938341152 284 6457060
SGTC_1715 st032160 10.2275 µM 0.643750849716841 0.268142843341395 no 900 0.259868505118305 273 5289825
SGTC_1534 6-azauridine 81.6 µM 0.641008889899401 0.269042487136118 no 901 0.260758453568373 287 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_497 capsazepine 133 µM 0.640899069896717 0.269078550877748 no 902 0.260794130101976 276 2733484 A calcium channel blocker.
SGTC_2610 ononetin 44.17 µM 0.640754594219792 0.269125998875541 no 903 0.260841068831286 288 259632
SGTC_2904 7225135 42.03 µM 0.63901272351966 0.269698385781189 no 904 0.261407327379801 324 4446116
SGTC_2814 7977482 42.97 µM 0.63865156778429 0.269817139528459 no 905 0.261524813179616 285 6456762
SGTC_822 1487-0950 154 µM 0.638214389039134 0.269960925869312 no 906 0.261667065910044 269 1958375
SGTC_1588 farnesol 29.9 µM 0.637670548321733 0.27013984641407 no 907 0.261844080572505 293 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1744 st037937 38.9 µM 0.637377700509738 0.270236216264461 no 908 0.261939425012723 287 1016152
SGTC_3197 9113331 49.47 µM 0.637241399867464 0.270281075705542 no 909 0.261983807403465 280 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3017 9080681 49.47 µM 0.635360091455423 0.270900634424431 no 910 0.262596795083047 307 16451914
SGTC_1177 0983-0204 23.6 µM 0.63522250778533 0.270945971728974 no 911 0.262641652824912 296 766818
SGTC_2288 7946289 167.31 µM 0.634860068659911 0.271065422721759 no 912 0.262759841143783 299 1246052
SGTC_3079 9117512 49.47 µM 0.634570620038804 0.271160836705829 no 913 0.262854247413478 339 7185044
SGTC_2162 5663267 200 µM 0.633799923645686 0.271414971068608 no 914 0.263105701517839 311 6456493
SGTC_2872 9044037 25.97 µM 0.633643120153303 0.271466690980067 no 915 0.263156876632036 292 6465195
SGTC_1454 4239-0054 42.6 µM 0.633612152512642 0.271476905897063 no 916 0.263166983976008 300 1340767
SGTC_266 formosanin C 406 nM 0.633540669418069 0.271500485882535 no 917 0.263190315675161 279 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_739 1486-1183 203 µM 0.63203479082528 0.271997464025377 no 918 0.263682071864665 284 4346692
SGTC_656 4090-1979 187 µM 0.630803296143264 0.272404224517419 no 919 0.26408457396852 283 22330961
SGTC_321 4534-3890 65.3 µM 0.630324428672069 0.272562475131687 no 920 0.26424117164557 302 699746
SGTC_2710 st078562 53.7235 µM 0.63010357297434 0.272635476358261 no 921 0.264313411085701 308 17250908
SGTC_963 1269-2853 151 µM 0.630042912632221 0.272655528612166 no 922 0.26433325416831 277 3668223
SGTC_2546 rhodinyl acetate 100 µM 0.628480647619589 0.273172212529838 no 923 0.264844560144268 282 6708682
SGTC_1169 aniline yellow 25.8 µM 0.625268342320756 0.274236132090533 no 924 0.265897476957863 300 6051 A DNA damaging agent.
SGTC_2447 5741742 33.78 µM 0.624878824099277 0.274365279990606 no 925 0.266025295755395 290 1776504
SGTC_2619 obliquin 87.91 µM 0.623834223418637 0.274711773902271 no 926 0.266368230737363 296 6708593 A bioactive alkalod. YER133W GLC7
SGTC_254 nsc-64875 3.808 µM 0.623819529837691 0.274716649299669 no 927 0.266373056130492 290 56993
SGTC_2774 tamoxifen 10.92 µM 0.623604292083662 0.274788071060968 no 928 0.266443745587689 293 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1469 k284-2957 126 µM 0.6235794818727 0.274796304354472 no 929 0.266451894490932 292 23884841
SGTC_1191 1487-1166 10.6 µM 0.623179621007336 0.274929015357131 no 930 0.266583246009875 302 3955771
SGTC_568 1193-0097 7.48 µM 0.621414832805317 0.275515113133598 no 931 0.267163357570693 278 3646150
SGTC_400 oxethazaine 37.5 µM 0.621080352790443 0.275626265382769 no 932 0.267273377806381 297 4621 A local anesthetic.
SGTC_389 tpck 16.7 µM 0.620414153434501 0.275847718140038 no 933 0.267492578306865 284 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1605 st000082 49.1 µM 0.619787116526739 0.276056232655246 no 934 0.267698975918275 297 1114022
SGTC_3285 9112818 20.8695 µM 0.619547897825757 0.276135802702469 no 935 0.267777739108294 302 17017947 YPR165W RHO1
SGTC_1296 1068-0102 11.9 µM 0.618342084757536 0.276537057220428 no 936 0.268174932915965 302 767053
SGTC_2430 5571206 200 µM 0.616949579230159 0.277000792155287 no 937 0.268633991653848 304 1731771
SGTC_3129 9127257 49.47 µM 0.615887813541858 0.277354639060206 no 938 0.268984282562916 308 837894
SGTC_3183 9108214 49.47 µM 0.615267653471075 0.277561417479769 no 939 0.269188987806287 274 4974831
SGTC_2931 9014674 55.67 µM 0.61508279591513 0.277623068642265 no 940 0.269250021541526 310 2996810
SGTC_1012 4112-3522 18 µM 0.615080161842216 0.277623947170559 no 941 0.269250891273786 300 3112398
SGTC_2420 aureobasidin a 50 nM 0.614814593241987 0.277712527820448 no 942 0.269338585364374 278 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_939 1165-0479 45.3 µM 0.614134466766743 0.277939447553936 no 943 0.269563236963697 304 1377347
SGTC_898 1000-0849 28.3 µM 0.614051893470898 0.27796700375099 no 944 0.269590518020821 303 6751807
SGTC_2334 9017922 200 µM 0.613948181247798 0.278001616277862 no 945 0.2696247850424 313 3163164
SGTC_1028 k015-0029 4.8 µM 0.613351954572981 0.278200639510786 no 946 0.269821823549327 298 4588309
SGTC_3331 9141060 1.957 µM 0.611776667073133 0.278726811843057 no 947 0.270342764636511 293 4906567 YPR165W RHO1
SGTC_1176 0848-0131 83.3 µM 0.611466177666372 0.278830577615138 no 948 0.270445501486671 306 6769040
SGTC_2135 5326629 150.42 µM 0.611081230119952 0.278959253444975 no 949 0.270572902637251 303 5020077
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.610168621284794 0.279264425175191 no 950 0.270875056810584 294 279621
SGTC_1216 1165-0504 9.65 µM 0.609734902389606 0.27940951540877 no 951 0.271018715101996 316 6304004
SGTC_2350 9023895 38.85 µM 0.609182886850505 0.279594231882275 no 952 0.271201611083312 307 2997209
SGTC_27 0485-0001 32.618 µM 0.608501653880228 0.279822269021529 no 953 0.271427404692297 301 2054479
SGTC_956 1185-0240 191 µM 0.608338457464842 0.279876911072868 no 954 0.271481509792864 293 1416193
SGTC_402 epigallocatechin gallate 10 µM 0.608027771307385 0.279980950508361 no 955 0.271584527550397 302 65064 An antioxidant.
SGTC_888 0916-0002 6.97 µM 0.607075306622361 0.280300019046053 no 956 0.271900468408106 291 2802138 YIL048W NEO1
SGTC_2723 salbutamol 83.58 µM 0.606698120371369 0.280426422277183 no 957 0.272025634904411 303 9884233 β2-adrenoceptor agonist
SGTC_1304 1165-0502 251 µM 0.604423719060377 0.281189207459197 no 958 0.272780985082153 291 767425
SGTC_3261 9137475 49.47 µM 0.603570954481962 0.281475464369417 no 959 0.273064464231463 257 17027690
SGTC_2712 st079126 47.7 µM 0.603142825821738 0.281619232041683 no 960 0.273206839378128 302 3152970
SGTC_3048 9093155 49.47 µM 0.60055886526924 0.282487689490554 no 961 0.274066921321714 279 25236002
SGTC_2972 9093619 59.92 µM 0.599116205937898 0.282973120334538 no 962 0.274547697734621 270 25236256
SGTC_879 0831-1030 162 µM 0.598797466728024 0.283080424761815 no 963 0.274653975921693 308 1549252
SGTC_3277 9138724 49.47 µM 0.596267726678949 0.283932760485558 no 964 0.275498193725201 290 15943418
SGTC_247 mechlorethamine 29.705 µM 0.596237889196706 0.283942820839248 no 965 0.275508158617621 298 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2719 novobiocin 32.65 µM 0.594715379026804 0.284456394426567 no 966 0.276016870023334 316 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.592734470417298 0.285125258663468 no 967 0.276679434336702 333 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1185 1319-0113 81.3 µM 0.590714400511459 0.285808117005112 no 968 0.277355898754803 317 4672763
SGTC_590 k048-0076 22.4 µM 0.589078218004103 0.286361776671422 no 969 0.277904402240266 318 6832814
SGTC_1282 0886-0010 32.4 µM 0.588246906753364 0.286643274866025 no 970 0.27818328846895 309 2836211 YNL267W PIK1
SGTC_2338 7999974 200 µM 0.586135912100171 0.287358687915588 no 971 0.278892092427756 330 315925
SGTC_1275 0867-0008 21.1 µM 0.585704855773915 0.287504876072424 no 972 0.279036935208362 305 3422836
SGTC_2678 equilin 100 µM 0.58305413900119 0.288404610513312 no 973 0.279928427631451 277 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1398 3558-0053 112 µM 0.581055547457102 0.28908387013519 no 974 0.280601508457104 297 4532369
SGTC_2787 5284540 71.43 µM 0.580531467952713 0.289262113032094 no 975 0.2807781361891 323 736958
SGTC_2313 7726885 200 µM 0.579644658250961 0.28956384046236 no 976 0.281077135354607 295 726423
SGTC_2676 harmalol 100 µM 0.579227209239992 0.289705924118746 no 977 0.281217936822455 301 5459187 A monoamine oxidase inhibitor
SGTC_1291 0993-0025 5.79 µM 0.579018543288211 0.289776958280318 no 978 0.281288330571633 304 4353356
SGTC_98 0074-0023 107.663 µM 0.577258749360687 0.290376352977926 no 979 0.281882337645552 303 3563821
SGTC_1125 tnp00248 1.32998 µM 0.576385747249592 0.290673917170016 no 980 0.28217723798491 327 24207736
SGTC_2128 5255449 168.493 µM 0.575906875492961 0.29083720194104 no 981 0.282339064036782 286 736008
SGTC_2746 daunorubicin 9.88 µM 0.57590064932341 0.29083932521071 no 982 0.282341168352204 283 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_605 1315-0399 119 µM 0.574833832628584 0.291203241637976 no 983 0.282701841501901 320 24020461
SGTC_1456 k015-0012 13 µM 0.574059348925318 0.291467569483015 no 984 0.282963820312585 326 2989616
SGTC_338 4055-0136 114 µM 0.572428921621141 0.292024392563329 no 985 0.283515713420457 303 2900563
SGTC_2381 9035592 200 µM 0.571688415060569 0.292277453593195 no 986 0.283766542157758 308 4749657
SGTC_2076 5212012 200 µM 0.571368447355572 0.292386831044582 no 987 0.283874956366665 310 604802
SGTC_92 0063-0024 660.874 µM 0.569789658161344 0.292926801242192 no 988 0.284410185353713 312 3594437
SGTC_513 4245-1575 41.7 µM 0.569494512281639 0.293027796995759 no 989 0.284510296912625 303 719745
SGTC_2034 5197015 53.07 µM 0.568985223614012 0.293202108090669 no 990 0.284683083879202 327 780676
SGTC_1382 3002-2117 298 µM 0.567691577024404 0.293645092546649 no 991 0.285122205964934 345 1497314
SGTC_1656 st012921 11 µM 0.566800775439336 0.293950310467266 no 992 0.285424771847361 317 6732821
SGTC_2238 6671620 73.2395 µM 0.56485577326271 0.294617241501869 no 993 0.286085933863041 286 729941
SGTC_1700 st030840 7.9285 µM 0.564729167029384 0.294660678302524 no 994 0.286128996164751 331 5499307
SGTC_2870 9038528 12.99 µM 0.563065437265617 0.295231754607828 no 995 0.286695162838284 316 6463316
SGTC_2001 4023502 57.655 µM 0.56241154330117 0.295456343514671 no 996 0.286917828050936 314 108941 YCR052W RSC6
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.562315117376315 0.295489468976738 no 997 0.28695067012057 321 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2340 7987427 183.45 µM 0.561599818212898 0.295735250969545 no 998 0.287194352150632 303 2239331
SGTC_2869 9037858 32.47 µM 0.561427630731579 0.295794429864988 no 999 0.287253026140473 306 27187042
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.559309966955428 0.296522691480056 no 1000 0.287975097168557 331 279621
SGTC_1836 st055642 81 µM 0.556104672240578 0.297626547877627 no 1001 0.289069650633532 334 8571
SGTC_1051 3253-3903 78 µM 0.554655548938354 0.298126219499188 no 1002 0.289565142979256 312 5509239
SGTC_2173 5763948 167 µM 0.553496625363146 0.298526102282844 no 1003 0.289961695373309 314 2867177
SGTC_307 1501-1223 22.3 µM 0.553094735188387 0.298664830126854 no 1004 0.290099270791325 324 2830329
SGTC_2991 9074669 71.4286 µM 0.549812858526257 0.299798791340465 no 1005 0.291223869109427 331 17333109
SGTC_3161 9100388 49.47 µM 0.54776383863811 0.300507760225811 no 1006 0.291927035727111 334 25236368
SGTC_324 1315-0088 19.6 µM 0.54634771768945 0.300998185652432 no 1007 0.292413470628393 342 6787421
SGTC_1281 0884-0031 11.8 µM 0.546097846515291 0.301084757489033 no 1008 0.292499340006536 327 1548255
SGTC_790 1575-0012 79.1 µM 0.5458285489692 0.301178072462589 no 1009 0.292591898466604 349 378741 YLR208W SEC13
SGTC_761 k216-0224 480 µM 0.545825261639665 0.30117921164395 no 1010 0.292593028416741 361 1340404
SGTC_60 0986-0278 202 µM 0.545749589969654 0.301205435215137 no 1011 0.292619039516473 353 3110598
SGTC_33 0986-0033 35.816 µM 0.545635420408921 0.301245001949861 no 1012 0.292658285771623 305 2848082
SGTC_1161 k007-0610 110 µM 0.545117787879551 0.301424422636847 no 1013 0.292836254744699 319 5843850
SGTC_1437 4092-1038 11.6 µM 0.544557298380374 0.30161875253464 no 1014 0.293029015149343 328 3977136
SGTC_3237 9133362 49.47 µM 0.544501115901633 0.301638234927821 no 1015 0.293048340357776 345 43845137
SGTC_111 0083-0039 52.457 µM 0.544344477547493 0.301692555384455 no 1016 0.293102222712124 329 759313
SGTC_1659 st012954 42.1 µM 0.543637499842761 0.301937782179215 no 1017 0.293345474600613 322 24207262
SGTC_632 0781-2353 4.65 µM 0.542941590076945 0.302179257296801 no 1018 0.293585009636279 332 6811515 YHR007C ERG11
SGTC_1328 1441-0025 69.2 µM 0.541833670200595 0.302563875364599 no 1019 0.29396654700994 323 4562601
SGTC_536 3852-0578 10.6 µM 0.538441364835274 0.303742887479329 no 1020 0.295136187697873 334 2869208
SGTC_3230 9131665 49.47 µM 0.536497113237102 0.304419544398864 no 1021 0.295807515243195 331 15943720
SGTC_385 1494-0393 12.4 µM 0.535153655546718 0.304887498937653 no 1022 0.296271805043729 329 3090647
SGTC_2778 tioconazole 65.09 nM 0.535010613332003 0.304937342368397 no 1023 0.296321259136247 326 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.534373126855038 0.305159520185198 no 1024 0.296541703825479 355 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2487 5918373 44.05 µM 0.533064664256715 0.305615772616334 no 1025 0.29699440924412 332 2876279
SGTC_2045 5106652 78.05 µM 0.530686356998223 0.306445845924973 no 1026 0.297818070868935 319 673349
SGTC_1995 st072814 61.1 µM 0.530608654651154 0.306472982276876 no 1027 0.297844998516319 319 5769371
SGTC_3185 9108267 49.47 µM 0.530030547450131 0.306674910654429 no 1028 0.298045375665674 328 4910486
SGTC_2036 5160441 105 µM 0.5291753874621 0.306973719043733 no 1029 0.298341894389291 333 134534 YIL048W NEO1
SGTC_862 0452-0056 10.2 µM 0.528764421473042 0.307117363648432 no 1030 0.298484440757996 320 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1805 st050013 60.3 µM 0.528674032795119 0.3071489611014 no 1031 0.29851579684689 327 4037144
SGTC_1685 st024049 53.0905 µM 0.528596254682218 0.30717615138597 no 1032 0.298542779494423 344 1941139
SGTC_409 arachidonic acid 100 µM 0.523615632099808 0.308919518961632 no 1033 0.300272953331312 326 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1365 1672-3266 55.4 µM 0.523103232858042 0.309099119458545 no 1034 0.300451207955538 344 6415873
SGTC_3294 9122953 26.2835 µM 0.523098735120238 0.309100696157812 no 1035 0.300452772850504 323 16459826
SGTC_663 1486-0733 13.9 µM 0.523035838697133 0.309122745108971 no 1036 0.300474656747493 328 722445 YPR165W RHO1
SGTC_264 promethazine 12.5 mM 0.52205927646606 0.309465176648214 no 1037 0.300814529720815 342 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1740 st038286 13.222 µM 0.521751543877852 0.309573117385998 no 1038 0.300921665824272 305 716786
SGTC_2563 tomatine 8.54 µM 0.521242101208763 0.309751846355821 no 1039 0.301099064448284 380 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1568 digitonin 820 nM 0.518178454069332 0.310827620431392 no 1040 0.302166883049302 357 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3148 9097893 49.47 µM 0.517273714657338 0.311145622188232 no 1041 0.302482550172987 282 17174100
SGTC_2132 5317594 122.667 µM 0.5163929656089 0.311455327186254 no 1042 0.302789988907239 361 794577
SGTC_2702 st077768 96.8 µM 0.514613376892498 0.312081505659836 no 1043 0.303411607785179 299 6484119
SGTC_1692 fluoroquinolonic acid 71 µM 0.513896587531924 0.31233387376441 no 1044 0.303662146729874 343 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1689 st020265 53.493 µM 0.513446171241814 0.312492501964671 no 1045 0.303819627689838 353 5758320 YPR016C TIF6
SGTC_2256 7954252 200 µM 0.512901370203988 0.312684417142931 no 1046 0.304010157460349 344 2972920
SGTC_333 3486-0131 40.1 µM 0.51178510891575 0.313077797266922 no 1047 0.304400706629912 339 6744690
SGTC_735 3076-0345 636 µM 0.510974613465351 0.313363556288356 no 1048 0.304684416602535 321 2888990
SGTC_846 0335-0850 148 µM 0.510164596723892 0.313649258518718 no 1049 0.304968076422075 331 6819598
SGTC_1223 0764-0573 147 µM 0.507666252280149 0.314531157023038 no 1050 0.305843709715447 325 1609797
SGTC_3223 9129970 49.47 µM 0.505130469577275 0.315427354402767 no 1051 0.306733600947872 340 17248386
SGTC_3188 9110789 49.47 µM 0.503796985047565 0.315899071495642 no 1052 0.307202023289229 343 849217
SGTC_809 3998-0021 90 µM 0.50309165808552 0.316148700633118 no 1053 0.307449915701392 339 715485
SGTC_2351 9026858 72.31 µM 0.502931992741839 0.316205220990801 no 1054 0.307506043490563 356 1409300
SGTC_3289 9119912 71.43 µM 0.501955636895589 0.316550937172404 no 1055 0.307849363732006 347 17014829
SGTC_564 3555-0129 330 µM 0.501070310715947 0.316864559441377 no 1056 0.308160820316402 328 563260
SGTC_2131 toluylene red 5.2905 µM 0.500606711867961 0.317028839493516 no 1057 0.308323968922516 296 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2015 5119600 184 µM 0.500034071888552 0.317231808959907 no 1058 0.30852554329759 359 2828786
SGTC_3115 9123671 49.47 µM 0.499998048206237 0.317244579218497 no 1059 0.308538225885231 341 3286988
SGTC_2981 9013952 38.96 µM 0.499857074039564 0.317294556117109 no 1060 0.308587859798805 294 2996344
SGTC_48 0382-0018 55 µM 0.499632927740739 0.317374025314435 no 1061 0.308666783998213 302 762596
SGTC_24 0417-1663 219 µM 0.498335046351834 0.317834343738447 no 1062 0.309123954960397 351 4329390
SGTC_2046 4110841 106 µM 0.497581175074166 0.318101847952921 no 1063 0.309389637448785 331 44119630 YMR134W ERG29
SGTC_1732 st034308 51.822 µM 0.497375820511519 0.318174732565238 no 1064 0.309462026647311 320 830119
SGTC_1964 st076914 61 µM 0.496477500431839 0.318493647813065 no 1065 0.309778778867829 370 24208661
SGTC_2525 harmine 47.85 µM 0.494470062663805 0.319206800138147 no 1066 0.310487122017967 352 5280953 A monoamine oxidase inhibitor
SGTC_164 4100-3994 89.624 µM 0.493936113342882 0.319396601144719 no 1067 0.310675649547509 371 4615967
SGTC_2309 7664088 163.95 µM 0.493249589732977 0.319640706722347 no 1068 0.310918121275194 360 704922
SGTC_2679 rapamycin 1 nM 0.493208094646661 0.31965546353789 no 1069 0.310932779463962 322 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_146 3448-8650 53.125 µM 0.493130260189971 0.319683144421966 no 1070 0.310960275387784 373 2891488 YIL048W NEO1
SGTC_1641 st009299 47.1 µM 0.490140160225901 0.320747296607458 no 1071 0.312017360698637 334 4046054
SGTC_1921 5740136 50 µM 0.487132343566214 0.321819242160239 no 1072 0.313082273522025 358 1774243
SGTC_784 4579-0127 173 µM 0.487012263869631 0.321862067831472 no 1073 0.313124820014234 353 1948547
SGTC_1383 3049-0032 20.7 µM 0.486744933359956 0.321957418079941 no 1074 0.313219549170815 372 712864
SGTC_881 0833-0569 170 µM 0.486343654677137 0.32210056636665 no 1075 0.313361766296258 327 5418700
SGTC_168 3970-0862 530.542 µM 0.485041905959992 0.322565121261219 no 1076 0.313823309876391 351 3135186
SGTC_983 1491-0821 12.2 µM 0.484755803194449 0.32266725989201 no 1077 0.313924788592295 321 46495113
SGTC_2107 5363541 170.161 µM 0.484728921713226 0.322676857263338 no 1078 0.313934323995328 340 244052
SGTC_3003 9075612 71.4286 µM 0.484237498931842 0.322852328487645 no 1079 0.314108663450018 358 6501993
SGTC_2227 7312221 64.1025 µM 0.484194819004101 0.322867569975383 no 1080 0.314123806740416 358 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3354 9151612 71.43 µM 0.484038475404068 0.322923404594484 no 1081 0.314179281778284 344 27261949
SGTC_2399 5884133 200 µM 0.48399706414651 0.322938194367325 no 1082 0.314193976342315 338 722445
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.482480072311115 0.323480171391913 no 1083 0.314732475662219 352 23847180
SGTC_2086 5274770 176.623 µM 0.481820952968777 0.323715772393264 no 1084 0.314966571713969 345 689278
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.481530671124331 0.323819555526333 no 1085 0.31506969322365 317 66535 A nucleotide analog.
SGTC_2051 5263410 176 µM 0.478350308146459 0.324957511884195 no 1086 0.316200447645476 337 227584
SGTC_10 0279-0212 42.575 µM 0.4782292291618 0.325000867175148 no 1087 0.316243530452706 329 39851 YBR002C RER2
SGTC_2522 biochanin a 4.94 µM 0.477990890133855 0.32508621721532 no 1088 0.316328344484435 363 5280373 A possible chelator.
SGTC_2121 5257820 149.641 µM 0.477238444743335 0.325355730759293 no 1089 0.316596169003533 328 791256
SGTC_552 k242-0005 476 µM 0.477010700215249 0.325437323115668 no 1090 0.31667725108931 377 4088318
SGTC_3012 9080433 71.4286 µM 0.476227510897323 0.325717974429918 no 1091 0.316956151010836 370 17688859
SGTC_2889 9059656 51.95 µM 0.472624011806571 0.327010538401361 no 1092 0.318240724167119 348 3949838
SGTC_279 1273-0055 2.93 µM 0.472027948223486 0.327224545267567 no 1093 0.318453419947574 366 2847562
SGTC_1160 4092-0570 10.5 µM 0.471997255997402 0.327235566347126 no 1094 0.3184643735996 333 4994975
SGTC_1003 4049-0218 100 µM 0.471058116754597 0.3275728687633 no 1095 0.318799616724751 349 295161
SGTC_1154 4088-0362 150 µM 0.470703163561156 0.327700390867478 no 1096 0.318926362473998 346 6618304
SGTC_2635 hydroquinidine 100 µM 0.470695851897535 0.327703017900437 no 1097 0.3189289735262 323 442912 An experimental heart treatment.
SGTC_29 0299-0004 12.984 µM 0.46880974468496 0.328380968424321 no 1098 0.319602816976027 343 16871 A napthoquinone isolated from Swertia calycina.
SGTC_32 0928-0142 34.1 µM 0.468219297584082 0.328593317612014 no 1099 0.319813886710754 367 2244242
SGTC_433 pimozide 108 µM 0.468156938833467 0.328615747630383 no 1100 0.319836181777205 339 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1506 4226-2149 212 µM 0.467209974334695 0.32895644016812 no 1101 0.320174829070911 356 991114
SGTC_2664 lyso-paf C-16 73.48 µM 0.465805639487226 0.329461944003509 no 1102 0.320677314019812 359 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2050 5263056 171 µM 0.465495600917845 0.329573587420213 no 1103 0.320788293233612 348 763468 YGL055W OLE1
SGTC_342 k048-0088 23.3 µM 0.46499378770465 0.32975432016392 no 1104 0.320967952682984 330 6820570
SGTC_1080 nisoldipine 24.4 µM 0.464712764684834 0.329855550615175 no 1105 0.321068583019401 369 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_840 0245-0196 390 µM 0.464588720908199 0.329900237779161 no 1106 0.321113005508418 337 3827528
SGTC_300 r073-0011 5.04 µM 0.463402368818758 0.330327747442556 no 1107 0.321537990517187 340 2735780
SGTC_2735 sertaconazole 140 nM 0.46189549270142 0.330871079419257 no 1108 0.322078133218478 369 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_560 2332-1943 155 µM 0.461790643423717 0.330908898037221 no 1109 0.322115730653296 346 21177716
SGTC_1316 1272-0050 65.9 µM 0.461779708075638 0.330912842462784 no 1110 0.322119652015826 350 7340392
SGTC_755 1995-0008 37.3 µM 0.458011659163672 0.332273108371539 no 1111 0.323472032441443 343 689533
SGTC_2407 paclitaxel 400 µM 0.457582779609715 0.332428074496758 no 1112 0.323626108818317 407 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_126 0417-1624 672.48 µM 0.456199066831547 0.332928243659073 no 1113 0.324123418199724 390 41912 YDL195W SEC31
SGTC_857 0438-0306 1.35 µM 0.45529269292035 0.333256030932701 no 1114 0.324449341217791 331 4686136
SGTC_608 k048-0125 159 µM 0.45382712055802 0.333786320031095 no 1115 0.324976630951892 349 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2087 5276107 200 µM 0.453664674052576 0.333845118634229 no 1116 0.325035098247388 347 144405
SGTC_85 0868-0259 160.055 µM 0.452196916355924 0.334376568204692 no 1117 0.32556356472902 363 83173
SGTC_1340 1486-1359 257 µM 0.45157577071261 0.334601574333718 no 1118 0.325787314068475 353 4309068
SGTC_3239 9133757 49.47 µM 0.449595848663498 0.335319184925502 no 1119 0.326500940988249 375 17036923
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.448896346720484 0.335572859000309 no 1120 0.326753215794463 353 1241132 A phosphatase inhibitor.
SGTC_310 1273-0058 1.06 µM 0.448878559656107 0.335579310449254 no 1121 0.326759631718088 324 2734232
SGTC_2072 5231554 129 µM 0.448795385680992 0.335609478670606 no 1122 0.326789633856285 349 789545
SGTC_1064 honokiol 6.76 µM 0.445183060631317 0.336920733416677 no 1123 0.328093733627212 354 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1733 st037357 54.9 µM 0.444502907112318 0.337167847996453 no 1124 0.328339513755079 369 1272339 YGL099W LSG1
SGTC_3356 9151811 4.48 µM 0.443951140825626 0.337368368334781 no 1125 0.328538954504164 361 1859254 YPR165W RHO1
SGTC_104 0074-0074 590.992 µM 0.443321886823616 0.337597105283301 no 1126 0.328766463497625 347 3943124
SGTC_45 0kpi-0036 14.9 µM 0.443126310302027 0.337668210546708 no 1127 0.328837187809133 372 2795021
SGTC_112 phenothiazine 287.218 µM 0.442236148148479 0.337991917740134 no 1128 0.329159165334471 383 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_109 0132-0036 33.701 µM 0.442003370863059 0.338076586903873 no 1129 0.329243383333533 355 67274 A color developer.
SGTC_189 3970-0742 2.116 µM 0.441097899157245 0.338406016204213 no 1130 0.329571062175202 385 2891807
SGTC_3209 9113616 49.47 µM 0.440577772324425 0.33859530504531 no 1131 0.329759348752611 385 16649353
SGTC_64 000l-0018 272.079 µM 0.439011586865228 0.339165530277853 no 1132 0.33032657032204 349 6811119
SGTC_2393 9031399 185.94 µM 0.437971417610173 0.339544444481048 no 1133 0.330703501551564 371 1526623 YDL150W RPC53
SGTC_1825 st052143 62.6 µM 0.437308532485861 0.339786005807179 no 1134 0.330943804109343 365 674173
SGTC_1812 st052057 4.327 µM 0.436703809548703 0.340006429713584 no 1135 0.331163083057623 340 3645418
SGTC_26 0302-0163 425.158 µM 0.436692025305993 0.340010725660352 no 1136 0.331167356724477 385 3100915
SGTC_1173 0443-0020 122 µM 0.435820836881904 0.340328374982129 no 1137 0.33148336230982 370 5331295
SGTC_3282 9108498 15.4605 µM 0.435425335148112 0.340472618696902 no 1138 0.331626862002842 346 16459645
SGTC_3304 9125678 46.087 µM 0.434488632918107 0.340814337087683 no 1139 0.331966823745297 354 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2094 5332512 191.667 µM 0.434401696105118 0.340846059141551 no 1140 0.331998383153154 368 755774
SGTC_2438 5259590 200 µM 0.434106289587602 0.340953857346768 no 1141 0.332105629192925 388 1201127
SGTC_3061 glucosamine 200 µM 0.431401109728603 0.341941620452516 no 1142 0.333088371579372 359 91431 and experimental redox chemotherapeutic
SGTC_2939 9044578 71.43 µM 0.431168012322939 0.342026783866473 no 1143 0.333173105389318 373 2653634
SGTC_1236 0330-0013 258 µM 0.431116684729257 0.342045537763894 no 1144 0.333191764753117 370 4617066
SGTC_3042 9091578 49.47 µM 0.429491610600122 0.342639502950753 no 1145 0.333782748939133 357 25236497
SGTC_1476 4112-3294 3.34 µM 0.428975246057533 0.342828315947637 no 1146 0.333970619605957 364 704369
SGTC_1718 roemerine 11.9335 µM 0.425951445138642 0.34393478080773 no 1147 0.335071613511091 344 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3245 9134821 49.47 µM 0.423854060887481 0.34470303909113 no 1148 0.335836124496343 374 17014901
SGTC_2434 5670830 169.91 µM 0.421390092096284 0.345606393526796 no 1149 0.336735126450263 375 1549830
SGTC_3317 9138495 8.753 µM 0.421385385436718 0.345608119953046 no 1150 0.336736844613936 365 17020139
SGTC_1525 8-methoxypsoralen 92.5 µM 0.421238028639595 0.34566217278653 no 1151 0.33679063886081 404 4114 Related to psoralen; DNA damaging agent.
SGTC_2532 xanthone 78.9 µM 0.421176237404147 0.345684839737872 no 1152 0.336813197436163 371 7020 An insecticide.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.420473015475962 0.345942842418678 no 1153 0.337069969118905 400 5393153
SGTC_2032 5185112 25.99 µM 0.418247341663464 0.346759883298382 no 1154 0.337883142870116 352 5718189
SGTC_1779 st039427 55 µM 0.417738027668411 0.346946951967832 no 1155 0.33806933279014 388 1124498
SGTC_422 cantharidin 155 µM 0.416318853037008 0.347468404935829 no 1156 0.338588349341516 352 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1876 myriocin 605 nM 0.415475937860137 0.347778257376603 no 1157 0.33889676316161 393 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_319 1348-1596 45.5 µM 0.415171043104987 0.347890360595661 no 1158 0.339008347568246 388 5380505
SGTC_2318 6029776 164 µM 0.414572924362015 0.348110314567139 no 1159 0.339227286178948 384 818325
SGTC_764 1951-2361 146 µM 0.412617932430637 0.348829605322902 no 1160 0.339943280396462 370 5438930
SGTC_3073 9114972 49.47 µM 0.408985494064743 0.350167512745131 no 1161 0.341275153280162 393 41905075
SGTC_360 0957-0399 1.01 µM 0.406616072905384 0.351041227432883 no 1162 0.342144995205399 355 6752301 YPR165W RHO1
SGTC_9 0092-0002 10.449 µM 0.405997840993814 0.351269327834206 no 1163 0.34237209338435 377 759368
SGTC_743 1275-0778 158 µM 0.40535402908329 0.351506923088302 no 1164 0.342608648585479 395 2849257 YMR203W TOM40
SGTC_1374 2889-5571 141 µM 0.404776241285106 0.351720201916658 no 1165 0.342820997181134 355 2853281
SGTC_2987 9018338 71.43 µM 0.403781124513997 0.352087638793717 no 1166 0.34318683894243 387 5055682
SGTC_2850 9015429 58.44 µM 0.402473485739043 0.352570681278229 no 1167 0.343667798854142 374 6457570
SGTC_554 4483-2211 187 µM 0.402266069982196 0.352647322647135 no 1168 0.343744111297707 368 747107
SGTC_326 k292-0812 17.5 µM 0.401900569626683 0.352782391780838 no 1169 0.343878601750822 396 3579357
SGTC_362 0310-0100 9.03 µM 0.40137956741932 0.352974958054006 no 1170 0.34407034521672 338 790235
SGTC_2053 5265679 138 µM 0.400132726412555 0.353435952563557 no 1171 0.344529380512734 362 764595
SGTC_1247 0448-0043 5.84 µM 0.398535475410661 0.354026818352028 no 1172 0.345117756879174 391 3089013 YGL099W LSG1
SGTC_2726 cimetidine 79.27 µM 0.398454304490457 0.354056855044512 no 1173 0.345147667673676 393 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_574 1315-0397 40 µM 0.397445971080593 0.354430056947924 no 1174 0.345519310568384 367 6794277
SGTC_35 0133-0054 64.071 µM 0.39296820619834 0.356089041005567 no 1175 0.347171482016904 371 99677
SGTC_1609 st001574 46.4 µM 0.392527424992593 0.356252495701618 no 1176 0.347334275863716 421 3960012
SGTC_672 1441-0018 53.7 µM 0.390277164873374 0.357087369737572 no 1177 0.348165803476891 369 251141
SGTC_1768 st044301 37.178 µM 0.390022856378697 0.357181764440329 no 1178 0.34825982286572 419 3931349
SGTC_972 1319-0219 195 µM 0.389803948105855 0.357263026223848 no 1179 0.348340762047553 394 23903702
SGTC_1041 0206-0046 107 µM 0.389788252243781 0.357268852994071 no 1180 0.348346565703661 381 50494
SGTC_2842 9000675 19.48 µM 0.389649713332506 0.357320284196182 no 1181 0.348397792986463 366 2989072
SGTC_3074 9116018 49.47 µM 0.387969261457747 0.357944341507565 no 1182 0.349019390604759 393 17027303
SGTC_1220 1838-0075 193 µM 0.38716858884469 0.358241815233805 no 1183 0.349315701358982 381 5529645
SGTC_181 1447-1644 8.07 µM 0.385169343687548 0.358984969777596 no 1184 0.350055977334608 388 534600
SGTC_665 3914-0008 307 µM 0.384747340280809 0.359141904207342 no 1185 0.350212308777102 375 1069549
SGTC_2084 5306078 60.6385 µM 0.382149993847018 0.360108326687168 no 1186 0.351175055517866 409 679340
SGTC_1265 0819-1001 68.8 µM 0.379800448169485 0.360983318342032 no 1187 0.352046774819587 420 3106768
SGTC_2296 7971656 126.45 µM 0.378703774619568 0.361391978797343 no 1188 0.35245392502543 373 666570
SGTC_932 2857-0803 154 µM 0.378505260738977 0.361465969213042 no 1189 0.352527643231644 392 674898
SGTC_1632 st005650 90 µM 0.378394100641345 0.361507403248135 no 1190 0.352568924996317 356 2759605
SGTC_115 0527-0192 112.043 µM 0.37821838662573 0.36157290255124 no 1191 0.352634183830112 414 4233931
SGTC_3116 9124943 49.47 µM 0.377377807477045 0.361886293625438 no 1192 0.352946428430879 345 41905195 YPL160W CDC60
SGTC_1929 genistein trimethyl ether 50.5 µM 0.377356601994355 0.361894200812673 no 1193 0.352954306778813 385 136420
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.376173211620362 0.362335561620185 no 1194 0.353394064664315 414 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1287 0971-0001 34.6 µM 0.374652203356155 0.362903110192173 no 1195 0.353959571712528 363 4665869
SGTC_2956 9076196 2.52 µM 0.374290717716992 0.363038039190102 no 1196 0.354094018614451 400 16423868
SGTC_2789 5281112 71.43 µM 0.374085604284812 0.363114607884263 no 1197 0.354170314287669 367 765948
SGTC_855 0428-0020 25 µM 0.373945620178069 0.363166866990275 no 1198 0.354222387284526 376 6812414
SGTC_2591 skatole 100 µM 0.372546876415179 0.363689188158779 no 1199 0.354742858620443 402 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2247 cerulenin 830 nM 0.372327313850139 0.363771200606976 no 1200 0.354824582316432 355 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.371877870112113 0.363939099239509 no 1201 0.354991891244211 378 77254
SGTC_738 1315-0003 72.4 µM 0.368705144271571 0.365125075431361 no 1202 0.356173756965708 406 6251474
SGTC_635 k038-0028 24.7 µM 0.368066092086713 0.365364112007454 no 1203 0.356411976720647 399 4035102
SGTC_2583 asiatic acid 100 µM 0.365126054130131 0.366464501702631 no 1204 0.357508656580502 416 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_182 3448-4371 550.524 µM 0.364163514165708 0.366824997814574 no 1205 0.357867955293017 356 3491403
SGTC_3296 9122258 64.045 µM 0.363131808564836 0.367211528696699 no 1206 0.358253212142119 388 4730474
SGTC_1838 st055369 84.5 µM 0.361762422162548 0.367724780336021 no 1207 0.358764787795887 344 676036
SGTC_1933 st074711 15.9 µM 0.359860074565473 0.368438180025221 no 1208 0.359475887703543 373 17250958
SGTC_3158 9100007 49.47 µM 0.359754220643593 0.368477889671535 no 1209 0.359515470354806 365 19297233
SGTC_1956 st077085 54 µM 0.359555910749661 0.368552286687741 no 1210 0.35958962973105 418 24208685
SGTC_2424 5537928 59.2 µM 0.359038086190374 0.368746574563732 no 1211 0.35978329878343 396 5382802
SGTC_314 1671-0008 2.74 µM 0.358181527950789 0.369068029014206 no 1212 0.360103735003727 392 3913060
SGTC_2154 5570129 200 µM 0.354758714474497 0.370353475804798 no 1213 0.361385180114361 409 673366
SGTC_2755 lomerizine 42.69 µM 0.352047679799189 0.371372641436904 no 1214 0.362401252558564 378 3949 A calcium channel blocker.
SGTC_1452 4194-0072 190 µM 0.351742699059097 0.371487350169627 no 1215 0.362515617546043 400 1343545
SGTC_1037 k284-1091 78.7 µM 0.351296755538824 0.371655098079174 no 1216 0.362682864369833 368 3334711
SGTC_2031 5180455 200 µM 0.350911833200733 0.371799911615735 no 1217 0.362827246857609 392 29949
SGTC_2043 5101342 149 µM 0.350818386013594 0.371835070581528 no 1218 0.362862301383687 390 678451
SGTC_1683 st010134 710 nM 0.350494701574764 0.371956863248726 no 1219 0.362983732911166 381 3818134
SGTC_1691 st019933 84.6 µM 0.348603317368746 0.37266878976082 no 1220 0.36369356844809 424 6176082
SGTC_298 1391-0729 10 µM 0.3485063707283 0.372705292708877 no 1221 0.363729965106025 395 3237558
SGTC_2833 9001315 45.46 µM 0.348496161707906 0.372709136738851 no 1222 0.363733797948093 371 2989378
SGTC_951 1171-0579 82.7 µM 0.347999964005571 0.372895986672659 no 1223 0.363920105263168 403 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2650 prasterone 100 µM 0.347868749264939 0.372945402353726 no 1224 0.363969377832859 390 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1030 k029-0042 36.7 µM 0.347705870618124 0.373006745620596 no 1225 0.364030543674146 377 6080581
SGTC_684 1140-0066 328 µM 0.346874922813712 0.373319746812179 no 1226 0.36434264350708 376 6813534
SGTC_1994 st072947 40.9 µM 0.346866123517548 0.373323061776375 no 1227 0.364345948960393 411 5286565 YDL195W SEC31
SGTC_133 0724-0033 378.92 µM 0.344825550469492 0.374092060820596 no 1228 0.365112761677644 416 280309
SGTC_3137 9097352 49.47 µM 0.342891159874767 0.37482150749304 no 1229 0.365840171228679 428 44120435
SGTC_2378 9074213 121.43 µM 0.34122839355679 0.375448884582925 no 1230 0.36646582483325 381 657714
SGTC_2569 tetrandrine 100 µM 0.33907281042593 0.376262696339037 no 1231 0.367277440279705 359 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1241 0364-0022 50.8 µM 0.335758776551861 0.377514938372092 no 1232 0.368526389398659 408 4563895
SGTC_2793 7325131 81.82 µM 0.334640483144878 0.377937788585973 no 1233 0.368948151360349 391 4176441
SGTC_128 0906-2981 13.371 µM 0.334177042444457 0.378113068146751 no 1234 0.369122983320809 396 6740226
SGTC_36 0335-0881 14.2 µM 0.333221440864474 0.378474568800956 no 1235 0.369483567310206 387 23828853
SGTC_850 0388-0143 75.9 µM 0.332284164220917 0.378829240543824 no 1236 0.369837348177682 390 67273
SGTC_2383 9036125 200 µM 0.332261430495748 0.378837844406238 no 1237 0.369845930532868 399 79580
SGTC_2463 5473429 200 µM 0.3314631234212 0.37914001174013 no 1238 0.370147345663578 410 5399405
SGTC_3283 9109332 35.8195 µM 0.330560733969329 0.37948166424042 no 1239 0.370488154996467 379 17027281
SGTC_2160 5660466 132.927 µM 0.330167872120913 0.379630434581468 no 1240 0.370636560615486 417 2859134
SGTC_1824 st053723 68.6 µM 0.330139451545618 0.379641197678861 no 1241 0.370647297383474 396 675225
SGTC_700 3453-2283 142 µM 0.328997015059459 0.380073924575606 no 1242 0.371078972101616 379 565664
SGTC_2800 7887935 81.82 µM 0.32789255599524 0.380492409337713 no 1243 0.371496451163698 383 2961002
SGTC_999 SEC7.066 22.7 µM 0.327509308485483 0.380637656350887 no 1244 0.371641351842055 403 740511 YDR170C SEC7
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.327486964587905 0.380646124986219 no 1245 0.371649800327574 384 4174840
SGTC_2729 fluphenazine 10.66 µM 0.327256918084442 0.380733319005569 no 1246 0.371736787159349 407 3372 An atypical antipsychotic.
SGTC_2764 methyldopa 94.69 µM 0.325462137091317 0.38141379857548 no 1247 0.372415667145006 417 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_940 3232-1287 54.8 µM 0.324105955995762 0.381928229229621 no 1248 0.372928908940657 423 1585493 YIL048W NEO1
SGTC_3213 9129884 49.47 µM 0.322326636217012 0.382603482307213 no 1249 0.373602628125979 385 17190742
SGTC_1370 2001-0092 44.6 µM 0.321859794946959 0.382780708104693 no 1250 0.373779456344762 426 790957
SGTC_1800 st050079 29.0735 µM 0.320987936677073 0.383111755207066 no 1251 0.374109766363377 405 3645560
SGTC_2966 9084041 48.03 µM 0.320432442960971 0.383322722322787 no 1252 0.37432026753925 379 17741380
SGTC_1183 1254-0324 198 µM 0.319780567979536 0.383570337539261 no 1253 0.374567339630328 382 5799357
SGTC_1687 st020778 55.3625 µM 0.319009377382675 0.383863336290128 no 1254 0.374859700946243 402 4259299
SGTC_1472 k841-0093 193 µM 0.318546540971747 0.384039213808107 no 1255 0.375035198557663 409 X1472
SGTC_2950 9072895 21.46 µM 0.318283903196162 0.384139026606453 no 1256 0.375134796662941 370 17332245
SGTC_386 1509-0011 3.07 µM 0.314982719989361 0.385394260776953 no 1257 0.376387387007756 415 3107280
SGTC_1883 5-benzylidenerhodanine 20 µM 0.313102229185263 0.386109832226683 no 1258 0.377101497773086 409 1273210
SGTC_1704 st028805 70.8 µM 0.312231754784631 0.386441199817454 no 1259 0.377432200367602 390 2876101
SGTC_2271 7849410 118.62 µM 0.311224292150244 0.386824818763712 no 1260 0.37781505847891 430 972430
SGTC_3047 9092122 49.47 µM 0.311092423766664 0.386875039450233 no 1261 0.377865180278517 407 17173831
SGTC_1123 mangostin 811.285 nM 0.310327032208544 0.387166568150347 no 1262 0.378156138218554 399 5281650 An antioxidant.
SGTC_1976 st070609 63.5 µM 0.308701220220195 0.387786031963225 no 1263 0.378774407767153 436 682556
SGTC_839 0122-0028 230 µM 0.307617186643088 0.388199227254074 no 1264 0.379186820460905 406 759448
SGTC_3286 9117135 37.221 µM 0.307401849323346 0.388281321315138 no 1265 0.379268760368213 426 3438150
SGTC_1263 0774-1208 64.8 µM 0.306671726739552 0.38855970652225 no 1266 0.379546626121476 435 906585
SGTC_393 acivicin 6.25 µM 0.306082380360232 0.388784457556279 no 1267 0.379770961486016 410 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_810 3825-7150 143 µM 0.303539377125285 0.389754674215854 no 1268 0.380739421721337 397 22330411 YGL099W LSG1
SGTC_2743 auranofin 4.32 µM 0.30330704573351 0.389843348567135 no 1269 0.380827938613652 408 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_523 1934-0222 13.7 µM 0.302878639324035 0.39000687426341 no 1270 0.380991175285811 448 1361595
SGTC_2750 bromebric acid 70.15 µM 0.302380169642011 0.390197168099038 no 1271 0.381181134986553 398 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2263 7948595 193.29 µM 0.301490146464621 0.390537005273112 no 1272 0.381520381330356 412 2971371
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.30116369829303 0.390661673819573 no 1273 0.38164483502329 407 229346 A bile salt which induces apoptosis.
SGTC_2304 7443016 91.4 µM 0.301120726092111 0.390678085475958 no 1274 0.381661218471458 412 939854
SGTC_798 1287-0182 476 µM 0.29978760741456 0.39118731786771 no 1275 0.38216958433537 440 1649755
SGTC_2320 7373003 200 µM 0.298912998616331 0.39152150742145 no 1276 0.38250321441543 387 5415828
SGTC_1354 1498-1681 81 µM 0.297446984232631 0.392081853585096 no 1277 0.383062638830821 404 5754243
SGTC_562 3772-2733 112 µM 0.297120269718125 0.392206762324621 no 1278 0.383187344888629 441 2876874 YIL048W NEO1
SGTC_2013 4024628 200 µM 0.295066451226008 0.392992227373897 no 1279 0.383971558687619 412 5230760
SGTC_719 2810-4230 27.3 µM 0.29354126151968 0.393575805163581 no 1280 0.384554232818105 421 721079
SGTC_2166 5933061 31.504 µM 0.293294968704239 0.393670065748311 no 1281 0.384648349518338 409 2877375
SGTC_1179 1021-1431 9.29 µM 0.28930339033057 0.395198577977717 no 1282 0.38617460904504 437 2840958
SGTC_2188 6126565 140.678 µM 0.288367105444123 0.395557348127757 no 1283 0.386532872394553 414 874518
SGTC_445 e6 berbamine 66 µM 0.288353435901102 0.395562586745447 no 1284 0.386538103673898 424 6610268 A calcium/calmodulin antagonist.
SGTC_1887 st057648 70.8 µM 0.287844687936411 0.395757569080787 no 1285 0.386732814138512 428 688672
SGTC_828 2074-0507 139 µM 0.287289944194945 0.395970209454204 no 1286 0.386945160825382 406 X828
SGTC_391 gliotoxin 8.33 µM 0.286627901779959 0.396224019299847 no 1287 0.387198623953986 419 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1008 4106-0037 6 µM 0.286503534030807 0.396271703572302 no 1288 0.387246243552328 443 2905394
SGTC_170 4197-0004 226 µM 0.285721521412506 0.396571573287233 no 1289 0.38754570992424 406 218692
SGTC_2106 5357045 167.29 µM 0.284859768665724 0.396902090923107 no 1290 0.38787578972811 413 668842
SGTC_2810 7959871 45.46 µM 0.284407234075733 0.397075686235958 no 1291 0.388049157908965 398 2974535
SGTC_336 4111-0029 111 µM 0.280234145757792 0.398677467934879 no 1292 0.389648935603318 431 3131175
SGTC_2332 7982454 138.89 µM 0.279685139803794 0.398888323934704 no 1293 0.389859540118915 442 2981748
SGTC_1330 1469-0054 61.8 µM 0.279346067238171 0.399018565838103 no 1294 0.38998962811552 446 7102664
SGTC_2224 6650123 117.647 µM 0.279265680619446 0.399049444966982 no 1295 0.390020470914711 439 2908370
SGTC_1097 itavastatin 7.23 µM 0.278009097190806 0.399532221758609 no 1296 0.390502687693412 417 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1318 1280-3875 124 µM 0.277895075047694 0.399576036448587 no 1297 0.39054645230134 416 373245
SGTC_869 0564-0080 44.1 µM 0.277890081191606 0.399577955440346 no 1298 0.390548369102432 399 6843321
SGTC_1801 st050089 28.441 µM 0.277636860159634 0.399675264001455 no 1299 0.390645566889361 397 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_234 nsc-17383 10.7 µM 0.276751744587886 0.400015447872814 no 1300 0.390985368286899 413 408974
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.276085096043177 0.40027171660343 no 1301 0.391241353803145 443 140250 A respiratory chain inhibitor.
SGTC_3093 9117344 49.47 µM 0.275387199141239 0.400540043636841 no 1302 0.391509388817725 398 24824913
SGTC_1020 4335-0961 93.3 µM 0.274837260367375 0.400751516884436 no 1303 0.391720635178175 428 669075
SGTC_2110 5483698 200 µM 0.272912617165149 0.40149184712161 no 1304 0.392460193734757 391 2848765 YHR062C RPP1
SGTC_2417 cerulenin 830 nM 0.272779069653786 0.401543230452446 no 1305 0.39251152481102 448 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_901 1112-0062 60.1 µM 0.272017556696292 0.40183626034757 no 1306 0.392804259942443 404 1908457
SGTC_2601 securinine 100 µM 0.271508635593367 0.40203212377341 no 1307 0.392999929414185 441 442872 A GABA receptor antagonist.
SGTC_87 0100-0052 35.5 µM 0.271341980901554 0.402096267864779 no 1308 0.393064010520987 418 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1581 himbacine 57.9 µM 0.269852533526033 0.402669661445246 no 1309 0.393636852777375 429 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_507 nimesulide 162 µM 0.269635548790387 0.402753211714471 no 1310 0.3937203244688 445 4495 A COX2 inhibitor.
SGTC_529 4076-0302 30.3 µM 0.267201755757287 0.40369065048014 no 1311 0.394656912192786 420 5816522
SGTC_1867 st057372 64 µM 0.267161368842176 0.40370621123589 no 1312 0.394672459295835 418 688837
SGTC_1663 st014140 55.4 µM 0.266055358747892 0.404132407248571 no 1313 0.395098287385105 425 4207120
SGTC_770 0389-1121 67.2 µM 0.265608310919346 0.40430470744567 no 1314 0.395270442132196 410 6753108
SGTC_1219 1469-0211 33.1 µM 0.26518122745232 0.404469330361091 no 1315 0.395434927848463 462 6822282
SGTC_50 0929-0078 56.389 µM 0.26495091993724 0.404558111352108 no 1316 0.39552363556585 436 1377751
SGTC_1849 st056239 19.2 µM 0.262044180597963 0.405679048063148 no 1317 0.396643690363605 446 5393181
SGTC_3342 9147791 14.508 µM 0.261427493315807 0.405916963295178 no 1318 0.396881428710766 437 1838168
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.261286080231737 0.405971524740354 no 1319 0.396935950098628 449 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_94 0334-0113 514.748 µM 0.260873941010223 0.406130550932539 no 1320 0.397094860619626 457 6795178
SGTC_3187 9109394 49.47 µM 0.260719348291812 0.406190205381488 no 1321 0.397154472092679 428 17098090
SGTC_2982 9019404 25.97 µM 0.259697351925285 0.406584629458918 no 1322 0.397548617718223 371 22333232
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.258639161098068 0.406993122128048 no 1323 0.397956832431016 438 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1380 2291-0730 164 µM 0.25769836153082 0.407356383327488 no 1324 0.398319855359042 400 2999191
SGTC_762 1165-0429 115 µM 0.25725964329084 0.407525808325045 no 1325 0.398489172092884 449 5967793
SGTC_3315 9136395 68.55 µM 0.256278676280939 0.407904702465883 no 1326 0.398867830712201 473 16876844
SGTC_1857 st056007 79.3 µM 0.2560473236501 0.407994073956888 no 1327 0.398957147977572 414 619834
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.256015825971346 0.408006241876412 no 1328 0.398969308553475 425 23665772 A membrane-active detergent.
SGTC_83 0170-0301 39.027 µM 0.255815701171225 0.408083554485732 no 1329 0.399046574722277 425 3089716
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.254022494157565 0.408776469129321 no 1330 0.399739090063959 410 165521
SGTC_3220 9131269 49.47 µM 0.253982059374353 0.408792096864561 no 1331 0.399754709144423 454 17722206
SGTC_1466 k213-0079 57.5 µM 0.25377206186741 0.408873261630597 no 1332 0.399835829209581 454 3657981
SGTC_1485 3909-9022 254 µM 0.253346842630707 0.409037622307385 no 1333 0.400000100644201 447 714516
SGTC_3251 9135047 49.47 µM 0.253305098906945 0.409053758438841 no 1334 0.400016228106535 435 17682963
SGTC_518 1021-0119 62.6 µM 0.252919569707408 0.409202792910017 no 1335 0.400165183288547 418 1097762
SGTC_1548 st061468 90.8 µM 0.251522569684163 0.409742942633627 no 1336 0.400705057425432 458 390799
SGTC_3280 9140961 49.47 µM 0.251364219748117 0.409804179429068 no 1337 0.400766264142808 422 4901226
SGTC_2827 7993847 71.43 µM 0.251156435844928 0.409884536574573 no 1338 0.400846582178661 438 2985692
SGTC_726 3448-4391 34.2 µM 0.250853345902099 0.410001758613287 no 1339 0.400963747898095 440 1356692
SGTC_2186 6124449 200 µM 0.24992714596285 0.410360022364198 no 1340 0.40132184490694 449 3834182 YLR033W RSC58
SGTC_567 1080-0542 68.4 µM 0.249455887835314 0.410542338638503 no 1341 0.401504079442917 436 5950415
SGTC_2137 5261020 140 µM 0.247646592316858 0.41124248252188 no 1342 0.402203928942636 428 763655
SGTC_2450 5739737 12.93 µM 0.246991659311477 0.411495992063058 no 1343 0.402457339523745 445 2262825
SGTC_1406 3909-7906 11.9 µM 0.245955112347235 0.411897291099436 no 1344 0.402858490197215 445 X1406
SGTC_606 k015-0008 38.6 µM 0.245843719214196 0.411940422429349 no 1345 0.402901606185585 437 1970475
SGTC_998 3996-0085 177 µM 0.244442554704266 0.412483042866766 no 1346 0.403444043632625 416 715391
SGTC_3333 9141820 12.094 µM 0.244136893875928 0.412601436538518 no 1347 0.403562399843273 455 1939433
SGTC_1681 tripelennamine 100 µM 0.241173793982902 0.413749564648504 no 1348 0.404710210436759 404 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_584 0986-0246 15.4 µM 0.241088512203111 0.413782620202865 no 1349 0.404743258077533 459 53315 YDR232W HEM1
SGTC_2934 9036370 36.88 µM 0.240141115348659 0.414149876002184 no 1350 0.405110430574844 432 6462800
SGTC_2151 5563267 85.4165 µM 0.239071690748729 0.414564525722266 no 1351 0.405524996427068 461 5310824
SGTC_1885 st057546 99.9 µM 0.2388059039489 0.414667594457391 no 1352 0.405628045990678 408 702008
SGTC_633 0437-0093 97.7 µM 0.238724130653469 0.414699306281813 no 1353 0.405659752050632 431 2831118
SGTC_1134 3477-0009 42.5 µM 0.238388291814308 0.414829550988262 no 1354 0.405789973743651 457 3973534
SGTC_1206 3978-0017 132 µM 0.237179702921554 0.415298342185481 no 1355 0.406258690918753 457 3873677
SGTC_1953 st076800 12.1 µM 0.23443813838713 0.416362194805392 no 1356 0.407322426666734 418 297591
SGTC_1259 0671-0132 43 µM 0.230940998945159 0.417720133869734 no 1357 0.40868031948404 401 X1259
SGTC_1298 1079-1278 263 µM 0.230713723518582 0.417808419053041 no 1358 0.408768605651757 444 2840950
SGTC_2273 7815444 169.05 µM 0.230682082241801 0.417820710441713 no 1359 0.408780897216096 476 2824616
SGTC_2335 9018011 154.17 µM 0.229507157150438 0.41827717925868 no 1360 0.409237379238474 455 6458208
SGTC_107 0358-0022 2.6945 µM 0.229238878070314 0.418381423521219 no 1361 0.409341628341417 456 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.228859499373796 0.418528847156657 no 1362 0.409489059980007 428 4330530
SGTC_141 0443-0274 32.331 µM 0.228231263786329 0.418772999817795 no 1363 0.409733228878041 438 1627241
SGTC_2804 7954240 19.48 µM 0.227309982831633 0.419131095946953 no 1364 0.41009135554729 420 828705
SGTC_923 1900-2434 73.3 µM 0.226948368498604 0.419271671497547 no 1365 0.410231945272135 480 5910570
SGTC_1435 4092-0789 56.7 µM 0.226748285182738 0.41934945719782 no 1366 0.410309739344893 459 2248285
SGTC_3050 9093513 49.47 µM 0.22616884411018 0.41957474227554 no 1367 0.41053505079859 447 25236664
SGTC_1645 Cervolide 78 µM 0.225916330099323 0.419672927272947 no 1368 0.41063324828068 443 23173 A fragrance.
SGTC_3312 9133330 71.43 µM 0.225681524985958 0.41976423100875 no 1369 0.410724564165014 450 17617324
SGTC_609 0986-0026 86.3 µM 0.224275997682154 0.42031085905279 no 1370 0.411271275797699 446 2848610
SGTC_664 1222-0054 14.9 µM 0.22193484410761 0.421221705260619 no 1371 0.412182302586561 429 6813991
SGTC_450 aminopyrene 156 nM 0.221740560891496 0.421297311859073 no 1372 0.412257926492818 460 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_571 k831-0106 44.2 µM 0.221433293295348 0.421416892999595 no 1373 0.412377535732876 458 4783639
SGTC_1446 4239-0190 62 µM 0.221071316026471 0.421557775123967 no 1374 0.412518452101931 463 1340085
SGTC_1227 3909-8010 46.6 µM 0.220241537340433 0.421880764163015 no 1375 0.412841524303364 441 15982272
SGTC_415 dibenzyl ketone 100 µM 0.219886741986444 0.422018883317401 no 1376 0.412979680997346 467 7593
SGTC_2025 5147754 141 µM 0.219729505889129 0.422080097212114 no 1377 0.413040911908147 463 315777 YLR208W SEC13
SGTC_2287 7945887 168.79 µM 0.218866608803338 0.422416066849914 no 1378 0.413376979078103 446 1245853
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.218714587810297 0.422475262195331 no 1379 0.413436192333546 430 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3109 9122853 49.47 µM 0.218498019312611 0.422559594670911 no 1380 0.413520550699955 468 1234709
SGTC_11 0438-0307 1.3 µM 0.217212002270522 0.423060446875884 no 1381 0.4140215657572 451 4011476
SGTC_754 3474-0146 171 µM 0.215382954052975 0.423773002065546 no 1382 0.414734379421047 415 24762078
SGTC_1285 0929-0069 65.5 µM 0.215194369774022 0.423846484388076 no 1383 0.414807890187039 428 1206237
SGTC_2819 7996655 46.38 µM 0.213905093161724 0.424348924958458 no 1384 0.415310534194805 476 6456960
SGTC_3319 9138450 16.7555 µM 0.213837834358031 0.42437513959033 no 1385 0.415336759869601 463 2029690
SGTC_294 k038-0071 157 µM 0.212203292475233 0.42501231734728 no 1386 0.415974219104906 449 24152826
SGTC_407 eburnamonine 100 µM 0.206170169446471 0.427365835597092 no 1387 0.418328994299719 423 3195
SGTC_1721 st082152 9.2685 µM 0.204109302569544 0.428170375820378 no 1388 0.419134042481636 427 5296051
SGTC_886 0866-0150 153 µM 0.203782413370862 0.428298017372057 no 1389 0.419261768281497 463 271463
SGTC_2565 isoliquiritigenin 100 µM 0.203580161912157 0.42837699495347 no 1390 0.419340798492727 439 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1785 bathophenanthroline 24 µM 0.202952511591333 0.428622105648466 no 1391 0.419586074968452 425 72812 An iron chelator.
SGTC_937 3122-0005 46.7 µM 0.202540000080226 0.42878321509934 no 1392 0.419747295396832 475 759535
SGTC_2206 7254556 146.969 µM 0.2014392923848 0.429213162717551 no 1393 0.420177546982774 452 4398905
SGTC_1928 4'-methoxychalcone 40.3 µM 0.201392361801409 0.429231496151165 no 1394 0.420195893630266 473 641818
SGTC_2204 7233102 200 µM 0.200552751578223 0.429559515665488 no 1395 0.420524153052911 453 2172480
SGTC_1628 st004252 77.7 µM 0.198738923968214 0.430268308859003 no 1396 0.421233487192191 435 692968
SGTC_187 1488-2104 32.728 µM 0.197740653127655 0.430658501268583 no 1397 0.421623990540181 464 2852859
SGTC_2520 obtusaquinone 4.71 µM 0.195847197304936 0.431398778793266 no 1398 0.422364883613782 481 5967872
SGTC_1442 4112-3290 3 µM 0.195732989144007 0.431443438075227 no 1399 0.422409581103533 467 704353
SGTC_1675 st018485 24.5 µM 0.195637931987303 0.431480609330358 no 1400 0.422446784253228 464 3323024
SGTC_3044 9093193 49.47 µM 0.195469165657987 0.431546605396211 no 1401 0.422512837154924 474 25236277
SGTC_143 4032-1194 15.74 µM 0.194608283122859 0.431883283170753 no 1402 0.42284980902382 441 1806963
SGTC_3339 9145883 14.936 µM 0.193942358163861 0.432143750022897 no 1403 0.423110508155165 470 2030670
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.193859483594365 0.432176167270284 no 1404 0.42314295460188 497 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1109 tnp00067 928.257 nM 0.192825330116284 0.432580725461078 no 1405 0.423547882594873 464 676295
SGTC_2478 5763493 32.33 µM 0.19242637273462 0.432736815484544 no 1406 0.423704117972243 454 1365576 YLR208W SEC13
SGTC_1151 3909-8316 15.3 µM 0.192208233213502 0.432822165890278 no 1407 0.423789548487252 460 800431
SGTC_767 0929-0023 86 µM 0.191223546142838 0.433207478632664 no 1408 0.42417522841881 441 1204563
SGTC_1776 st049249 45.9 µM 0.190507315605705 0.433487782968614 no 1409 0.424455805569515 441 1822314
SGTC_829 1635-0120 117 µM 0.189090555507642 0.434042345317036 no 1410 0.425010921785977 462 285054
SGTC_2091 4-phenylthiadiazole 200 µM 0.18860288130667 0.434233265704471 no 1411 0.425202037194303 445 270010
SGTC_679 0422-0091 41.4 µM 0.188255935250453 0.434369101537541 no 1412 0.425338013133346 477 627384 YHR062C RPP1
SGTC_444 curcumin 90.4 µM 0.188032886626944 0.434456433314858 no 1413 0.425425435581666 445 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1343 1487-0095 224 µM 0.185135344112235 0.435591217411453 no 1414 0.426561440082297 484 4560101 YGL055W OLE1
SGTC_3008 9078912 71.4286 µM 0.184375688875398 0.435888814472612 no 1415 0.426859370165171 475 16648731
SGTC_1043 0916-0009 19.3 µM 0.184063604118127 0.436011085078637 no 1416 0.426981779157318 482 3101130
SGTC_3256 9138902 49.47 µM 0.183968648161757 0.436048288757911 no 1417 0.427019025124151 474 17228773
SGTC_2626 ethyl orsellinate 100 µM 0.183057194400121 0.436405424459806 no 1418 0.427376571044449 466 75653 A natural product.
SGTC_1379 2144-0755 36.5 µM 0.183047035527317 0.436409405312274 no 1419 0.427380556513142 485 5392327
SGTC_3098 9119039 49.47 µM 0.182346864182568 0.436683789717264 no 1420 0.427655261416446 451 17161528
SGTC_236 1509-0011 5.31 µM 0.181878248757295 0.436867448599066 no 1421 0.427839137378249 475 3107280
SGTC_21 0849-0113 22.993 µM 0.18169241562479 0.436940283743467 no 1422 0.427912059179109 447 1560156
SGTC_2973 9094665 17.96 µM 0.181599589603279 0.436976666628401 no 1423 0.427948485471634 488 25237061 YIL048W NEO1
SGTC_52 0329-0193 875 nM 0.180982219809516 0.437218656442785 no 1424 0.428190766043228 475 3739292
SGTC_1981 st071826 47 µM 0.180088328677389 0.437569075650466 no 1425 0.428541612588031 440 11838600
SGTC_2070 5230947 200 µM 0.180003111296151 0.437602484748709 no 1426 0.428575062817748 473 2835538
SGTC_1305 1181-0477 144 µM 0.179760289587967 0.437697684366781 no 1427 0.428670380011757 449 6252086
SGTC_2711 st079103 59.1 µM 0.178756265368767 0.43809135594159 no 1428 0.429064543624469 476 54693780
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.178639589597054 0.438137107758541 no 1429 0.429110353234615 451 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2824 7998404 51.95 µM 0.177213468659458 0.438696396105163 no 1430 0.429670358320824 469 837851
SGTC_3080 9117754 49.47 µM 0.17681208942196 0.438853828956777 no 1431 0.429827996343369 470 9550191
SGTC_2971 9092186 9.93 µM 0.17626054883796 0.439070175321168 no 1432 0.43004462710456 398 25236400
SGTC_2122 5258151 111.688 µM 0.174666601549411 0.43969551644891 no 1433 0.43067080619755 439 2173356
SGTC_911 3456-4043 236 µM 0.173993394738156 0.439959675813005 no 1434 0.430935326644999 451 914281
SGTC_2998 9066762 71.4286 µM 0.173744795339975 0.440057230400246 no 1435 0.431033015647762 482 4945196
SGTC_2897 9048598 12.99 µM 0.17288074542899 0.440396326394015 no 1436 0.431372583339237 446 6467404
SGTC_155 k072-0202 43.6 µM 0.172820787704712 0.440419858400496 no 1437 0.431396148337612 483 5857737
SGTC_1826 st055655 41.6 µM 0.172651015815102 0.440486491043398 no 1438 0.431462874581019 477 676168
SGTC_1459 k035-0031 35.7 µM 0.171781148535327 0.440827925881278 no 1439 0.431804793248621 464 3877128 YMR208W ERG12
SGTC_2011 4012611 177 µM 0.171327223396594 0.441006115208122 no 1440 0.431983237873958 469 2049887
SGTC_2661 dactinomycin 12.96 µM 0.170347079633455 0.441390913523738 no 1441 0.432368594042509 468 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3052 9092717 49.47 µM 0.16979391663959 0.441608106306075 no 1442 0.43258610563983 460 25237534
SGTC_636 0kpi-0074 126 µM 0.168061060038543 0.442288604928889 no 1443 0.43326762157769 460 616434
SGTC_1761 st044296 37 µM 0.167765067297373 0.442404859362422 no 1444 0.433384052597816 450 1826700
SGTC_2429 5902844 64.44 µM 0.167562431556085 0.442484449659014 no 1445 0.433463764258956 477 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_147 4466-0538 29.23 µM 0.166061439634054 0.443074074156089 no 1446 0.434054299736589 429 6742687 YHR072W ERG7
SGTC_1651 st011928 86.1 µM 0.166047230795048 0.443079656322607 no 1447 0.434059890627677 466 720198
SGTC_659 k018-0002 107 µM 0.165298938715501 0.443373650606542 no 1448 0.434354347056074 465 6797879 YHR007C ERG11
SGTC_1793 st048256 72.231 µM 0.165230707243162 0.443400459423182 no 1449 0.4343811982736 486 672022
SGTC_2205 7238770 200 µM 0.16321152335635 0.444193933385894 no 1450 0.435175946768886 475 279867
SGTC_625 k213-0058 121 µM 0.16311000525697 0.44423383264921 no 1451 0.435215911120634 473 3655420
SGTC_631 k072-0230 41.5 µM 0.162797051176568 0.444356835327755 no 1452 0.435339115057842 457 5773147
SGTC_2279 7948423 32.93 µM 0.162584761823096 0.444440276048624 no 1453 0.435422692823056 417 1247112
SGTC_1355 1499-0035 1.68 µM 0.161928297133533 0.444698316266743 no 1454 0.435681159497082 468 1548538
SGTC_3117 9124945 49.47 µM 0.161417821466368 0.444898987974776 no 1455 0.435882165613779 463 17592065
SGTC_2963 9082507 9 µM 0.160989166592943 0.445067506242299 no 1456 0.436050966575644 467 16459611
SGTC_1351 1496-0003 46.5 µM 0.160983303944299 0.445069811110348 no 1457 0.436053275321993 473 3891978
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.157980051984452 0.446250765493983 no 1458 0.437236258761216 446 5282362
SGTC_882 0843-0131 351 µM 0.157963962997131 0.446257093383072 no 1459 0.437242597747793 480 5425421
SGTC_543 3844-1095 191 µM 0.156298510748012 0.446912198851866 no 1460 0.437898865082206 478 4230703
SGTC_597 k018-0003 82.8 µM 0.155695406441094 0.447149465696108 no 1461 0.43813655907176 480 6786234
SGTC_1550 gossypolone 36.6 µM 0.15569081221693 0.447151273179334 no 1462 0.438138369821884 467 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2149 5554786 194.827 µM 0.155485483210921 0.447232055889897 no 1463 0.43821929874113 452 745063 YPR165W RHO1
SGTC_1971 st069429 63.5 µM 0.154781765475667 0.447508936557602 no 1464 0.438496683498306 494 1246522 YGL099W LSG1
SGTC_1938 st074717 56.4 µM 0.15441132239573 0.447654699213151 no 1465 0.438642713372428 474 17250979
SGTC_194 1486-1323 56.904 µM 0.154051865331329 0.447796145828401 no 1466 0.438784420508785 482 5178754
SGTC_724 3910-0327 137 µM 0.153781647476003 0.447902481122182 no 1467 0.438890952442267 491 2885483
SGTC_1086 cerivastatin 2.18 µM 0.153021512472211 0.448201627150233 no 1468 0.439190655289631 472 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2353 9059630 146.67 µM 0.152284761793662 0.448491598548899 no 1469 0.439481171535105 461 4779114
SGTC_2912 7964298 10.93 µM 0.152016988053478 0.448596996152248 no 1470 0.43958676842197 468 2975850
SGTC_3316 9136639 10.545 µM 0.151480909979008 0.448808011099309 no 1471 0.439798184345574 487 4903665
SGTC_2874 9043904 71.43 µM 0.150490599772248 0.449197862242428 no 1472 0.440188783288433 453 4463428
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.150263168744415 0.449287400972381 no 1473 0.440278495049774 469 803109
SGTC_2038 4100038 30.985 µM 0.149525918875856 0.44957767117038 no 1474 0.440569329477086 479 3596803
SGTC_1786 berberine 21.6 µM 0.14936707938166 0.449640213033052 no 1475 0.440631993567294 489 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_427 1354-0053 47.3 µM 0.14782271654989 0.450248359323607 no 1476 0.441241340538917 459 6813657
SGTC_1978 st071761 42 µM 0.147122096818066 0.450524291193271 no 1477 0.441517824459528 445 5147680
SGTC_139 0099-0334 718.624 µM 0.146982747535953 0.450579175329286 no 1478 0.441572818941961 471 97690
SGTC_535 2293-4129 48.2 µM 0.146661629644309 0.450705654482499 no 1479 0.441699553069037 491 396118 YIL048W NEO1
SGTC_1646 st011709 75.6 µM 0.146640654437803 0.450713916190734 no 1480 0.441707831465499 493 5757843
SGTC_97 0535-0701 19.132 µM 0.145376405121713 0.451211917646716 no 1481 0.442206846365603 460 2832013 YGL099W LSG1
SGTC_2667 digitoxin 100 µM 0.144902528975373 0.451398602407946 no 1482 0.442393914839069 474 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_864 0469-0573 172 µM 0.144626134856151 0.451507493568242 no 1483 0.442503030772135 480 689425
SGTC_693 4161-2696 114 µM 0.143846759902527 0.451814564019969 no 1484 0.442810738877134 496 805759
SGTC_1156 4092-0367 4.88 µM 0.142300468462122 0.45242388150702 no 1485 0.443421338256339 485 1357585
SGTC_3221 9128209 49.47 µM 0.142139388702884 0.452487361595755 no 1486 0.443484953164823 485 16460723
SGTC_2054 5233173 129 µM 0.141173204940282 0.452868151386808 no 1487 0.443866556707022 466 6889
SGTC_1073 triclabendazole 3.09 µM 0.13998649596297 0.453335913275114 no 1488 0.444335329992473 457 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2791 5663188 71.43 µM 0.139302697647322 0.453605473665665 no 1489 0.444605479126556 500 54690634
SGTC_475 α-linolenic acid 10 µM 0.13878762584615 0.453808534435288 no 1490 0.444808986245775 465 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2515 chrysin 20.77 µM 0.138315221851483 0.453994784561121 no 1491 0.444995647920013 466 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1615 st002656 86.5 µM 0.138121493197311 0.454071166999943 no 1492 0.445072199732442 445 1584458
SGTC_355 1311-2252 105 µM 0.137706170358311 0.454234924291193 no 1493 0.44523632131174 495 5338538
SGTC_2349 9023730 187.07 µM 0.137527589098467 0.454305339338584 no 1494 0.445306893490448 468 4126287
SGTC_2553 4-methylesculetin 85.09 µM 0.137341532052533 0.454378703635101 no 1495 0.445380421812161 443 5319502
SGTC_78 0336-0123 156.75 µM 0.135690272381815 0.455029881020517 no 1496 0.446033069054141 464 6765896
SGTC_1342 1486-1464 234 µM 0.135596536540698 0.455066849568815 no 1497 0.44607012180237 486 3253938
SGTC_1984 st072354 53.1 µM 0.134329476233 0.455566604480228 no 1498 0.446571022900451 486 5762938
SGTC_509 pifithrin 175 µM 0.132915046154592 0.456124568117467 no 1499 0.447130283687207 494 4817 A p53 inhibitor.
SGTC_144 4161-2749 112.381 µM 0.128775016558732 0.457758218129213 no 1500 0.448767837401018 477 797501 YMR168C CEP3
SGTC_398 bronopol 33.3 µM 0.128135934799883 0.458010463219248 no 1501 0.44902069928834 498 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1208 2323-2347 50.3 µM 0.128019532538228 0.458056408928205 no 1502 0.449066757749227 497 5412760
SGTC_2549 cedrol 20.94 µM 0.127884931440451 0.458109538687958 no 1503 0.449120018045985 486 6708665 A sedative which affects the nervous system.
SGTC_1563 conessine 56.1 µM 0.126758141864652 0.458554334458647 no 1504 0.449565913186181 501 441082 An anti-amoebic, histamine inhibitor.
SGTC_2077 5212015 200 µM 0.126492053896561 0.458659379237278 no 1505 0.44967121929884 491 780900
SGTC_1855 st056195 39.6 µM 0.125958266511962 0.4588701136507 no 1506 0.44988247994544 495 4028379
SGTC_1114 scopoletin 1.73284 µM 0.125682038728446 0.458979170414113 no 1507 0.449991810066222 504 5280460 A coumarin with genotoxic properties.
SGTC_2716 st080858 38.6235 µM 0.124352025599687 0.459504312467148 no 1508 0.45051827822758 501 5296050
SGTC_1713 st033146 12.748 µM 0.124327128801777 0.459514143389243 no 1509 0.450528134129927 489 674619
SGTC_1831 st055328 12 µM 0.123537342422692 0.459826016726702 no 1510 0.450840802886474 490 1103068
SGTC_1727 st034309 9.9045 µM 0.122586765435574 0.460201416331943 no 1511 0.451217167522545 507 870305
SGTC_2766 oltipraz 83.91 µM 0.122102896077075 0.460392518516449 no 1512 0.451408764152842 464 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_796 1234-0020 70.7 µM 0.12143625241351 0.460655821626681 no 1513 0.451672752034577 498 46495034
SGTC_2480 5767542 37.17 µM 0.121348215840938 0.460690594573542 no 1514 0.451707615719985 487 2867358
SGTC_1948 st076329 66.6 µM 0.121326337656441 0.460699236130465 no 1515 0.451716279837716 502 24208413
SGTC_216 k038-0035 28.382 µM 0.119116791917679 0.461572068673127 no 1516 0.452591413716788 479 4444231 YPR107C YTH1
SGTC_102 gallobenzophenone 83.616 µM 0.117433156902317 0.462237276228626 no 1517 0.453258405215412 491 70837
SGTC_167 3672-0051 66.205 µM 0.116994621967258 0.462410559673245 no 1518 0.453432157631355 497 3237971
SGTC_708 3448-5400 146 µM 0.116846182508114 0.462469215912923 no 1519 0.453490973016231 511 3462195
SGTC_2517 totarol 10 µM 0.116560752586001 0.462582006583981 no 1520 0.453604070276182 471 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_603 3794-0023 45.9 µM 0.116385535852009 0.462651246831866 no 1521 0.453673499103221 477 3802260
SGTC_479 n-linoleoylglycine 10 µM 0.115788948074904 0.462887008390706 no 1522 0.453909904877844 497 6433346 An anti-infammatory.
SGTC_737 1950-0117 57.9 µM 0.114769171230417 0.463290037368954 no 1523 0.454314042672493 475 5393513
SGTC_3262 9137218 49.47 µM 0.114452022967468 0.463415386159179 no 1524 0.454439738263464 499 17650664
SGTC_3051 9093778 49.47 µM 0.112964254281592 0.464003455965254 no 1525 0.455029447358258 503 17217378
SGTC_2847 9005661 71.43 µM 0.10897628657831 0.465580163010159 no 1526 0.456610649434353 511 2991449
SGTC_629 3448-6466 76.7 µM 0.108916558110615 0.465603781788342 no 1527 0.456634336651878 501 573744
SGTC_1882 5615643 20 µM 0.108673871797675 0.465699749905419 no 1528 0.456730583187708 490 2253075
SGTC_2802 7925815 54.55 µM 0.108388021396612 0.465812789430492 no 1529 0.456843951348292 473 1262923
SGTC_2961 9083290 32.55 µM 0.106768025412785 0.466453468596975 no 1530 0.457486507232473 507 17741490
SGTC_3196 9111891 49.47 µM 0.106182326291116 0.466685123511201 no 1531 0.457718846621073 509 18891510
SGTC_1758 st042942 75.2445 µM 0.105675731040554 0.466885500476174 no 1532 0.457919818167719 505 669317
SGTC_2881 9058953 51.95 µM 0.105212638194727 0.467068677991735 no 1533 0.458103541277279 500 17122249
SGTC_1462 k081-0014 26.5 µM 0.104696747607955 0.467272747994865 no 1534 0.458308221406221 493 3270634
SGTC_1004 4084-0029 199 µM 0.104213106481794 0.467464068944709 no 1535 0.458500116569455 502 716894 YLR208W SEC13
SGTC_378 3970-0959 8.33 µM 0.103883034591967 0.467594644597703 no 1536 0.458631085345044 503 6615653
SGTC_280 3448-3607 3.04 µM 0.103420055219499 0.467777804006668 no 1537 0.458814797863807 497 626179
SGTC_1280 0880-0253 10.1 µM 0.101530359363705 0.468525457488094 no 1538 0.459564729392853 502 6836607
SGTC_3156 9099931 49.47 µM 0.100116296038078 0.469085000904976 no 1539 0.460125998982932 485 18111053
SGTC_2359 9039622 200 µM 0.09972116121845 0.469241366313849 no 1540 0.460282850029397 505 6463596
SGTC_1103 duloxetine 36.1 µM 0.0991823618330234 0.469454591271628 no 1541 0.46049673950924 479 60835 A selective serotonin reuptake inhibitor.
SGTC_228 caffeine 993.056 µM 0.0977656973901063 0.470015264983853 no 1542 0.461059173186635 487 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_125 0133-0007 11.75 µM 0.0976980950147372 0.470042021491314 no 1543 0.461086014139841 511 26541
SGTC_2314 7727897 200 µM 0.0974132332937112 0.470154769084514 no 1544 0.46119911803051 507 900724
SGTC_341 1486-1430 230 µM 0.0971173566399875 0.470271878895162 no 1545 0.46131659870545 499 2054753 YPL210C SRP72
SGTC_414 piperonyl butoxide 100 µM 0.0955059866792868 0.470909713969501 no 1546 0.461956467658157 497 5794 A potent inhibitor of cytochrome P450.
SGTC_2696 st077691 74.316 µM 0.0952267709922586 0.471020244674078 no 1547 0.46206735321449 512 757133
SGTC_2848 9016370 25.97 µM 0.0941059314004677 0.471463964153076 no 1548 0.462512504358908 519 7894410
SGTC_3005 9076496 71.4286 µM 0.0939550907790015 0.471523681856956 no 1549 0.462572415614255 495 21368410
SGTC_1194 1488-0194 225 µM 0.0939442326419313 0.471527980611075 no 1550 0.462576728309073 486 1391452
SGTC_1644 st010134 20.9 µM 0.0937011882035146 0.471624203166558 no 1551 0.462673263191082 514 3818134
SGTC_1078 idebenone 36.1 µM 0.0915179006254765 0.472488651660626 no 1552 0.463540541640206 521 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_357 1325-0123 420 µM 0.0903946882941008 0.472933425866275 no 1553 0.463986788770747 509 1098503
SGTC_191 3914-0123 66.505 µM 0.0893950082536935 0.473329311653365 no 1554 0.464383995213239 512 3144412
SGTC_134 0269-0018 6.916 µM 0.0874805538233944 0.474087532729893 no 1555 0.465144770983452 501 4378915
SGTC_2779 methotrexate 400 µM 0.0874439563889589 0.474102028093721 no 1556 0.465159315510636 519 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1519 esterone 74 µM 0.0869627039891248 0.474292643780668 no 1557 0.465350578830968 489 698 A steroid.
SGTC_2946 9065502 71.43 µM 0.0860336957867826 0.474660624344252 no 1558 0.46571981557823 494 16489101
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0859874129269439 0.474678957573619 no 1559 0.465738211596699 509 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2979 9012552 45.46 µM 0.0859333695063268 0.474700364927658 no 1560 0.465759692292911 505 17100905
SGTC_3031 9088762 49.47 µM 0.08587857817207 0.474722068615307 no 1561 0.465781470364997 481 205253
SGTC_272 doxorubicin 8.13 µM 0.0847349852061869 0.475175080349916 no 1562 0.466236040902123 486 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_750 4073-0104 132 µM 0.0841666928061777 0.475400210118013 no 1563 0.466461949742411 504 22330957
SGTC_2465 5809242 33.21 µM 0.0838036934373698 0.475544016901893 no 1564 0.466606255707128 516 2731748
SGTC_2792 7535235 81.82 µM 0.083713182299488 0.475579874529076 no 1565 0.466642237988822 494 1281891
SGTC_2582 agaric acid 100 µM 0.0836630754556005 0.475599725348205 no 1566 0.466662157848713 498 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2257 7960413 200 µM 0.0814201495134416 0.476488366204196 no 1567 0.467553912657162 504 2974689 YIL048W NEO1
SGTC_3018 9082602 49.47 µM 0.0811210324175966 0.476606884477825 no 1568 0.46767284967965 503 17332089
SGTC_685 1278-0033 54.9 µM 0.0802311621734896 0.476959487302348 no 1569 0.468026703105683 526 3590572
SGTC_1101 ebselen 5.29 µM 0.0799501339845989 0.47707084587493 no 1570 0.468138458129486 512 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2644 guaiazulene 100 µM 0.079457833780591 0.477265926160492 no 1571 0.46833423464768 510 3515 A coloring agent.
SGTC_1293 1000-1278 195 µM 0.0787232376598465 0.477557029434004 no 1572 0.468626380929111 513 678847
SGTC_677 0929-0063 136 µM 0.0782064531808645 0.477761826229453 no 1573 0.468831914423183 519 1539583
SGTC_3240 9133527 49.47 µM 0.0770621504699387 0.478215323379206 no 1574 0.469287051487819 511 17617455
SGTC_2360 9040895 200 µM 0.07702984603961 0.478228126319001 no 1575 0.46929990089667 484 4914414
SGTC_3131 9127911 49.47 µM 0.076936008904011 0.478265316119286 no 1576 0.469337225733076 488 45595681
SGTC_709 3807-1509 243 µM 0.0760272207149047 0.478625499380805 no 1577 0.469698720933842 527 1886677 YPL242C IQG1
SGTC_1277 0873-0036 22 µM 0.0759258934495463 0.478665659864087 no 1578 0.46973902816062 491 5965735
SGTC_2751 anetholtrithion 17.25 µM 0.0730163479690962 0.479818932415227 no 1579 0.470896554218362 506 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2598 perillyl alcohol 100 µM 0.0712534223426528 0.48051779576611 no 1580 0.471598032271096 507 10819 An apoptosis inducer.
SGTC_2014 4013930 200 µM 0.0699828584467756 0.48102151311598 no 1581 0.47210365158011 511 64556
SGTC_179 1273-0063 6.77 µM 0.069964983387983 0.481028599933351 no 1582 0.47211076525996 518 3108139
SGTC_1215 3852-0577 11.2 µM 0.0697070898225425 0.481130846114913 no 1583 0.472213399324509 496 2884876
SGTC_1674 st016616 23.6 µM 0.0676463542395153 0.481947902943378 no 1584 0.473033577268676 523 625830
SGTC_897 1000-0139 31.4 µM 0.0675124769706068 0.482000986327571 no 1585 0.47308686475119 519 6151020
SGTC_1565 sinapyl alcohol 95.1 µM 0.0666201727789029 0.482354800024456 no 1586 0.473442042933068 522 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2269 7935389 174.42 µM 0.0664730484684017 0.48241313864286 no 1587 0.473500607222723 497 97605
SGTC_343 4130-2827 29.8 µM 0.0656470474416043 0.482740676505093 no 1588 0.473829415714737 492 1118244
SGTC_2254 7938975 95.19 µM 0.0654166128582455 0.482832053843341 no 1589 0.473921148631213 513 2969277
SGTC_1865 st057639 52.2 µM 0.0648895225075051 0.483041071483347 no 1590 0.474130981420389 521 688818
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0647906402160006 0.483080283769756 no 1591 0.474170346909294 509 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2125 5246583 200 µM 0.0641218069061108 0.483345517371658 no 1592 0.474436619087464 518 835267
SGTC_1614 st002383 48.6 µM 0.0627771782874946 0.483878767620394 no 1593 0.474971969552161 523 1947235
SGTC_2771 fluoxetine 41.05 µM 0.0615763764525909 0.484355003721178 no 1594 0.475450095046987 522 3386 A selective serotonin reuptake inhibitor.
SGTC_3168 9103419 49.47 µM 0.0615513621820489 0.484364924580811 no 1595 0.475460055403799 530 16649256
SGTC_982 1491-0518 27.5 µM 0.0612512064226453 0.48448396950722 no 1596 0.475579574713065 507 3091256
SGTC_1861 st057647 17.4 µM 0.0609427878677969 0.484606292985619 no 1597 0.475702386481597 528 688668
SGTC_555 4296-0685 37 µM 0.0608396814327664 0.484647186885836 no 1598 0.475743443812292 526 2908540 YHR072W ERG7
SGTC_777 1315-0167 517 µM 0.06049277598705 0.484784777121277 no 1599 0.475881584621045 528 4221767
SGTC_462 ag-879 158 µM 0.0600498191819634 0.484960466043555 no 1600 0.476057978140275 530 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1092 toremifene 6.32 µM 0.0596487699095569 0.485119535798352 no 1601 0.476217687359935 524 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1634 st006576 41 µM 0.0595652396611024 0.485152667029074 no 1602 0.476250951960724 522 3915356
SGTC_1204 4049-0315 18.3 µM 0.0588273024197857 0.485445365054054 no 1603 0.476544830963385 487 588402
SGTC_2862 9027634 71.43 µM 0.0585637128766326 0.4855499180473 no 1604 0.476649806990938 519 5012562
SGTC_1573 oleylamine 1.06 µM 0.0582042568109254 0.485692498169382 no 1605 0.476792965014047 519 5356789 An amine of the fatty acid oleic acid.
SGTC_3120 9124077 49.47 µM 0.0575576998348177 0.485948962955776 no 1606 0.477050472211255 518 18774327 YGL155W CDC43
SGTC_418 lividomycin a 100 µM 0.0569440135310496 0.486192394563007 no 1607 0.477294896722196 497 72394 An antibiotic.
SGTC_2024 5144227 134 µM 0.0563429737781732 0.486430814637193 no 1608 0.477534292531029 507 3475211
SGTC_3248 9135562 49.47 µM 0.0552711894088962 0.486855981373011 no 1609 0.477961207294969 494 17650701
SGTC_2113 5491891 107.031 µM 0.0543463262545733 0.487222877876873 no 1610 0.478329620525264 515 789979
SGTC_520 3584-0023 682 µM 0.0543019917763896 0.487240465796209 no 1611 0.478347281344307 501 1340790
SGTC_1261 0712-0010 12.7 µM 0.053645841862519 0.487500769741437 no 1612 0.478608666273972 521 2840123
SGTC_379 3970-0972 5.9 µM 0.0514937255164494 0.488354581499362 no 1613 0.479466050766388 526 2898042 YBL034C STU1
SGTC_322 k048-0136 19.3 µM 0.0513684914874714 0.488404267430431 no 1614 0.479515945881548 506 6823282
SGTC_2469 5655019 90.81 µM 0.0506959603113029 0.488671093635981 no 1615 0.479783897858231 524 2788239
SGTC_2048 5246248 200 µM 0.0501348673033131 0.488893710722576 no 1616 0.480007457286759 528 677046
SGTC_1897 st060201 15 µM 0.0495819872738944 0.48911307264453 no 1617 0.480227750524069 493 611878
SGTC_1515 3460-0031 42.1 µM 0.0494832790120329 0.489152236704534 no 1618 0.480267081145048 514 2876596
SGTC_2115 tiliquinol 12.7705 µM 0.0484309370240123 0.489569776414954 no 1619 0.480686402023149 526 71208 A bioactive hydroxyquinoline.
SGTC_752 1896-0090 130 µM 0.0481709784071124 0.489672922462788 no 1620 0.480789989601785 523 772567
SGTC_1106 tegaserod maleate 11.7 µM 0.0477858844466754 0.489825720819652 no 1621 0.480943443142258 517 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_538 2922-0838 53.3 µM 0.0473478161335723 0.489999540260982 no 1622 0.48111800951352 500 777039
SGTC_1182 1222-0449 220 µM 0.0471655768518994 0.490071850846028 no 1623 0.481190631333384 530 658318
SGTC_989 1501-0895 10.3 µM 0.0469263922532883 0.490166757214597 no 1624 0.481285946642114 531 2830112
SGTC_3308 9128332 17.569 µM 0.0467985056584361 0.490217501731977 no 1625 0.481336910021067 527 17332805 YDL196W YDL196W
SGTC_3318 9139014 38.6185 µM 0.0463031482257964 0.490414057626278 no 1626 0.481534315040614 531 16643984
SGTC_1587 estradiol valerate 56.1 µM 0.0460043911357697 0.490532604401008 no 1627 0.481653374998396 518 13791 A steroid.
SGTC_1267 0828-0272 9.49 µM 0.0453448482560571 0.490794313876532 no 1628 0.481916220221026 516 745334
SGTC_3259 9138485 49.47 µM 0.0450866662229851 0.490896762712716 no 1629 0.482019114713915 503 17646153
SGTC_2259 7964009 200 µM 0.0439618811263009 0.491343093966262 no 1630 0.482467394464111 509 313134
SGTC_1200 1643-0193 18.4 µM 0.0436774714945459 0.491455953626114 no 1631 0.482580748609254 530 5403974
SGTC_6 0844-0013 19.835 µM 0.0418641663399449 0.492175526544559 no 1632 0.483303491229284 535 1584900
SGTC_1408 3909-7976 48.8 µM 0.0416650744825536 0.492254533653923 no 1633 0.483382848148078 530 24152374
SGTC_3004 9076122 71.4286 µM 0.0412819749973365 0.492406562737332 no 1634 0.483535551344094 529 44782551
SGTC_3226 9131256 49.47 µM 0.0409505323105576 0.492538093243276 no 1635 0.483667666124488 514 17178073
SGTC_1213 1315-0166 115 µM 0.040838206016059 0.49258266926254 no 1636 0.483712440377785 500 768401
SGTC_366 0181-0206 4.31 µM 0.0405331100913369 0.49270374522438 no 1637 0.483834055343586 516 274874
SGTC_1559 coumarin 343 70.1 µM 0.0401469536138 0.492856990668757 no 1638 0.483987984191798 517 108770 A hepatotoxic, DNA x-linker.
SGTC_1870 st057514 26.5 µM 0.0395893527020183 0.493078275356516 no 1639 0.484210258049234 525 5393161
SGTC_1553 gossypol 38.6 µM 0.0385649549736381 0.493484814503808 no 1640 0.484618621687604 529 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_89 0302-0250 142.109 µM 0.0379128409896908 0.49374361388799 no 1641 0.484878587390687 535 4203518 YLR208W SEC13
SGTC_1294 1000-1494 117 µM 0.037888547232923 0.493753255213072 no 1642 0.484888272238951 522 712797 YDL207W GLE1
SGTC_711 k292-0785 179 µM 0.0375170589201882 0.493900686118158 no 1643 0.485036369335197 534 4146315
SGTC_1489 4065-0444 182 µM 0.0366383998245575 0.494249398902572 no 1644 0.48538666272015 538 2877968
SGTC_3041 9091929 49.47 µM 0.0358985893173167 0.494543010369048 no 1645 0.485681610352841 523 25236887
SGTC_3310 9130229 44.1445 µM 0.0345913196808636 0.495061838669611 no 1646 0.486202811625178 529 7761258
SGTC_2932 9016711 44.54 µM 0.0341772142034596 0.495226190358788 no 1647 0.486367918177721 530 7117328
SGTC_2120 5538279 151.968 µM 0.0337534129564171 0.495394390979049 no 1648 0.486536892916051 530 2058197
SGTC_733 4069-0007 56.1 µM 0.0333095746039175 0.495570544915561 no 1649 0.486713859284057 534 5717425 YNL287W SEC21
SGTC_2130 NSC 7 2.4545 µM 0.0324537185472333 0.495910225976438 no 1650 0.487055111909095 539 21448
SGTC_246 cycloheximide 667 µM 0.0320808420849697 0.496058218010113 no 1651 0.487203790673764 534 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2623 humulene 100 µM 0.0319159379986551 0.496123667451212 no 1652 0.487269544214888 532 6187145 An anti-inflammatory.
SGTC_1926 methyl fluorone black 53.6 µM 0.0318792254595453 0.496138238451675 no 1653 0.487284182949932 536 72721 Reacts with homocysteine.
SGTC_692 k241-0027 77.8 µM 0.0310143653038225 0.496481498035276 no 1654 0.487629041664225 534 3600480
SGTC_2689 tacrolimus 100 µM 0.0309054683570753 0.4965247189937 no 1655 0.487672464444756 538 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_675 1309-0189 238 µM 0.0295524256925767 0.497061741889547 no 1656 0.48821200376074 529 4246530
SGTC_61 0978-8327 98.565 µM 0.029485190785663 0.497088427584039 no 1657 0.488238814924188 516 6150059 YHR072W ERG7
SGTC_837 0091-0265 12.5 µM 0.0293187310370929 0.497154495910023 no 1658 0.488305194058039 535 759367
SGTC_1901 st060216 58.6 µM 0.0290805727131538 0.497249021730419 no 1659 0.488400164986991 529 688792
SGTC_1022 4477-0945 21.3 µM 0.0288709040780752 0.497332240027818 no 1660 0.488483775563432 506 4648966
SGTC_2634 4'-methoxyflavone 100 µM 0.0286883844652817 0.497404682867233 no 1661 0.488556560205042 534 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_220 paclitaxel 373.376 µM 0.0286566877300336 0.497417263450057 no 1662 0.488569200176064 527 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1862 st057513 3.81 µM 0.0283046525442697 0.497556988035571 no 1663 0.488709584947129 534 5393163
SGTC_2801 7907800 81.82 µM 0.028046990179504 0.497659255751368 no 1664 0.488812336564054 541 6620925
SGTC_2391 6285546 200 µM 0.0273677551794586 0.497928848857978 no 1665 0.489083208124892 532 846083
SGTC_3150 9097574 49.47 µM 0.0273356086971658 0.497941608045311 no 1666 0.48909602791961 533 17217476
SGTC_1172 0370-0043 85 µM 0.0270577645864526 0.498051886607102 no 1667 0.489206830696622 529 376585
SGTC_2815 7968870 71.43 µM 0.026818492606162 0.498146855699765 no 1668 0.489302251777803 529 2977326 YHR190W ERG9
SGTC_457 grayanotoxin iii 135 µM 0.0265090968036488 0.498269657691329 no 1669 0.489425638974961 540 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_763 3453-1109 128 µM 0.0264337170408089 0.498299576626065 no 1670 0.489455700614964 536 1560353
SGTC_3276 9139060 49.47 µM 0.0259037443616781 0.498509928012613 no 1671 0.489667056740666 538 4870619
SGTC_572 0960-0087 17.7 µM 0.025019529185032 0.498860882635542 no 1672 0.490019693223365 531 6796365
SGTC_2649 anisomycin 9.56 µM 0.0250072053525809 0.498865774105572 no 1673 0.490024608183378 538 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_86 0417-1630 471.922 µM 0.0242292795714844 0.49917454205839 no 1674 0.490334861630634 535 3634867
SGTC_2762 leflunomide 42.06 µM 0.0241171618467375 0.499219042955885 no 1675 0.490379577064875 539 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2239 6685329 187.64 µM 0.0224725299752869 0.499871818306014 no 1676 0.491035512184496 528 805680
SGTC_3334 9142812 21.919 µM 0.0224291886959552 0.499889021024465 no 1677 0.491052798496252 528 45283678
SGTC_782 0083-0095 30.5 µM 0.0223032914909729 0.499938991266465 no 1678 0.491103011653167 518 3591729 An indicator and reagent.
SGTC_72 0744-0168 198.391 µM 0.0219958753740724 0.499938991266465 no 1679 0.491225622858927 540 677577
SGTC_1606 st000094 49.2 µM 0.0214517801950027 0.499723032813287 no 1680 0.491442634215193 536 1242210
SGTC_674 0498-0004 451 µM 0.021279633938059 0.499654705738838 no 1681 0.491511294962037 534 4231473
SGTC_1203 3992-3522 103 µM 0.0206703528917437 0.499412874311315 no 1682 0.491754309465264 536 5322312
SGTC_643 k048-0106 28.4 µM 0.0196978239800721 0.499026865651136 no 1683 0.492142213328193 536 6763920
SGTC_971 1315-0384 26.7 µM 0.0194045315146843 0.498910454434555 no 1684 0.492259197732044 538 6769120
SGTC_1916 st067606 49.2 µM 0.0192969606027267 0.498867758301713 no 1685 0.492302104282984 533 19590279
SGTC_899 1083-0020 478 µM 0.0191001523129235 0.498789642860613 no 1686 0.49238060496239 542 767123
SGTC_2217 6934799 96.0675 µM 0.0190313813149493 0.498762346882766 no 1687 0.492408035635117 529 675606
SGTC_942 3253-1115 227 µM 0.0190282546430986 0.498761105871894 no 1688 0.492409282770879 537 46497897
SGTC_377 3970-0964 33.1 µM 0.0188884605223678 0.498705620041242 no 1689 0.492465042534676 540 16481235
SGTC_1819 st053448 58.6 µM 0.0186466152641739 0.498609629046642 no 1690 0.492561507843225 538 2857616
SGTC_466 geldanamycin 89.2 µM 0.0182036959142726 0.498433829786397 no 1691 0.492738177106317 539 5288382 HSP90 inhibitor.
SGTC_2864 9034755 47.6 µM 0.0180031993574763 0.498354250732125 no 1692 0.492818150553649 535 4930451
SGTC_2065 5221596 34.26 µM 0.0177858101450119 0.498267966890858 no 1693 0.492904862417376 541 788581
SGTC_1500 4488-1866 171 µM 0.0177095530677063 0.498237699752249 no 1694 0.492935279798871 540 2900003
SGTC_1983 st071813 46.9 µM 0.0162588514412193 0.497661905003429 no 1695 0.493513942495745 514 11838595
SGTC_2781 5567276 71.43 µM 0.0161951719134147 0.497636630206829 no 1696 0.493539343607299 538 2853274
SGTC_785 1270-0111 65.3 µM 0.0155254449265458 0.49737081203689 no 1697 0.493806492411023 544 6741994
SGTC_3025 9087895 49.47 µM 0.0155168804818973 0.49736741277099 no 1698 0.493809908718572 534 17173641
SGTC_470 aa-861 153 µM 0.0134141037294215 0.496532817785725 no 1699 0.494648707352767 540 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_277 nystatin 15.5 µM 0.0124468063486108 0.49614890099989 no 1700 0.495034570901754 533 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2413 inermin 26.06 µM 0.0123863926066263 0.49612492312173 no 1701 0.495058670639921 539 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_175 3793-3120 23.7 µM 0.0123616034232541 0.496115084436777 no 1702 0.495068559336178 545 5322297
SGTC_2694 st077685 81.9 µM 0.0122007267492858 0.496051233463657 no 1703 0.49513273500339 535 2838096
SGTC_583 1488-1091 88.9 µM 0.012098035327164 0.496010475915787 no 1704 0.495173699930015 543 4303273
SGTC_2612 dictamnine 15.46 µM 0.0117971697258278 0.495891064585068 no 1705 0.495293719372249 545 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0116215168644302 0.495821349433763 no 1706 0.495363789921437 543 3256 An antibiotic and ribosome inhibitor.
SGTC_1908 st060353 56.5 µM 0.0106837442127945 0.495449157524482 no 1707 0.495737883802032 539 4227716
SGTC_1303 1160-0052 261 µM 0.00966566962554095 0.495045099133179 no 1708 0.49614401575907 545 3562476
SGTC_1985 st071382 65.5 µM 0.00961454732776361 0.495024809597695 no 1709 0.496164409657481 535 6123237
SGTC_1467 k284-1082 293 µM 0.00945397844903431 0.4949610827346 no 1710 0.496228464460627 543 3334705
SGTC_780 0109-0199 192 µM 0.00904872437642251 0.494800245350658 no 1711 0.496390130524945 544 610414
SGTC_2985 9022375 71.43 µM 0.00893578722106314 0.494755422960785 no 1712 0.496435184109654 533 4939335
SGTC_2197 6588183 93.1375 µM 0.00880003244328116 0.494701544822493 no 1713 0.496489340300778 546 884136
SGTC_1802 st050112 57.9 µM 0.00863361072268269 0.494635495769131 no 1714 0.496555730439117 543 4662563
SGTC_178 4092-0806 87.505 µM 0.00803594460356204 0.494398296698376 no 1715 0.496794156438355 546 2169044
SGTC_1079 idarubicin 2.36 µM 0.00687909304902288 0.493939176300615 no 1716 0.497255660576515 546 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2512 diallyl trisulfide 49.23 µM 0.00678553970737907 0.493902048070315 no 1717 0.497292982088852 544 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3027 9089541 49.47 µM 0.00625408757437747 0.493691133289799 no 1718 0.497504996306026 542 9943819
SGTC_3046 9092212 49.47 µM 0.00607823106424154 0.493621342371514 no 1719 0.497575151569395 543 25236637
SGTC_117 lucigenin 22.078 µM 0.00542632191996294 0.493362625561632 no 1720 0.497835221382703 545 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3173 9105693 49.47 µM 0.00492209344842691 0.493162519246019 no 1721 0.498036376744124 540 17096658
SGTC_88 0180-0332 8.668 µM 0.00395146163286976 0.49277732264785 no 1722 0.498423598987599 543 3101745
SGTC_368 fentichlor 4.58 µM 0.0031778372951143 0.492470313549484 no 1723 0.49873222847654 544 7329 A pesticide.
SGTC_2242 6630449 61.2675 µM 0.00226960301683826 0.492109890848816 no 1724 0.499094560174192 541 691249 YDR170C SEC7
SGTC_1391 3442-0225 151 µM 0.0014307501054467 0.491777007089732 no 1725 0.499429213484986 546 5227075
SGTC_3090 9117696 49.47 µM 0.000365247946102786 0.491354189921405 no 1726 0.49985428715471 548 7923821
SGTC_1880 MG-132 525 µM -6.04863135654299e-05 0.491185250903548 no 1727 0.499975869452148 549 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1120 ficusin 1.78878 µM -0.000637898424133996 0.49095612591642 no 1728 0.49974551536527 550 6199 A DNA cross-linker.
SGTC_2541 muurolladie-3-one 83.07 µM -0.000639127943572235 0.490955638029523 no 1729 0.499745024858082 548 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1750 st081859 2.357 µM -0.000651989552215619 0.490950534401936 no 1730 0.499739893819669 549 5291695
SGTC_1310 1188-0297 994 nM -0.000938945272917512 0.490836667606711 no 1731 0.49962541508669 548 1588352
SGTC_2983 9022671 12.99 µM -0.00107834249411571 0.490781353714953 no 1732 0.499569803669717 548 6405161
SGTC_3218 9131285 49.47 µM -0.0012154076186698 0.490726965389971 no 1733 0.499515122632369 548 17156417
SGTC_2368 9071271 200 µM -0.00136905228640367 0.490665998400384 no 1734 0.499453827329489 550 27209959
SGTC_775 4577-0580 57.3 µM -0.00155314107422085 0.490592951315606 no 1735 0.499380386607175 555 2006902
SGTC_1412 3909-8563 178 µM -0.00171083965316497 0.490530376210237 no 1736 0.499317474060321 550 23767530
SGTC_2813 7971799 71.43 µM -0.00215164986048686 0.490355463096707 no 1737 0.49914161656036 550 2234054
SGTC_1567 st069303 68.4 µM -0.00218097640103359 0.49034382641591 no 1738 0.499129916990851 552 5581319
SGTC_2344 7990960 76.95 µM -0.00224253019484148 0.490319402087203 no 1739 0.499105360640049 552 140813
SGTC_1181 1222-0449 220 µM -0.0023552362113206 0.490274680830747 no 1740 0.499060397563656 551 658318
SGTC_2319 6033012 152.6 µM -0.00388925106227119 0.489666002810557 no 1741 0.498448417223776 552 847246
SGTC_2959 9079155 11 µM -0.00403898579370323 0.489606591197147 no 1742 0.498388682177966 549 16189457
SGTC_1052 3253-3998 198 µM -0.00422871791580197 0.489531309786087 no 1743 0.498312990659363 557 5450317
SGTC_521 r062-0005 13.8 µM -0.0062623745484379 0.488724424837881 no 1744 0.497501690346437 553 2832033
SGTC_2405 ticlatone 3.52 µM -0.00728871708709284 0.488317224762681 no 1745 0.497092248330007 559 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1669 st015249 58.4 µM -0.00740730030359285 0.488270177801604 no 1746 0.497044941748362 550 722793
SGTC_867 0518-0118 155 µM -0.00753709369208275 0.488218683479836 no 1747 0.49699316312353 549 6848158
SGTC_1463 k081-0032 34.1 µM -0.00956732848230225 0.487413232785394 no 1748 0.496183246384987 546 977755
SGTC_3194 9111903 49.47 µM -0.00967412088538379 0.487370866656855 no 1749 0.496140644351825 557 17087251
SGTC_1965 Pectolinarigenin 58.4 µM -0.0101218343762003 0.487193253638484 no 1750 0.495962041261407 554 5320438 An anti-inflammatory.
SGTC_2734 clemastine 41.6 µM -0.0131743244401739 0.485982365736026 no 1751 0.494744356996236 553 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_929 2805-0021 398 µM -0.0135011625275343 0.485852720266944 no 1752 0.494613979062256 576 3098024
SGTC_1455 4262-0120 131 µM -0.0137802111383121 0.485742032428354 no 1753 0.494502665129971 560 1529587
SGTC_2117 5521686 200 µM -0.0149499616522969 0.485278049495646 no 1754 0.494036050365815 559 803312
SGTC_580 1123-0028 41 µM -0.0154331041894845 0.485086416213833 no 1755 0.493843326622078 553 1677248 YPR107C YTH1
SGTC_2693 st077581 40.7 µM -0.01624043210487 0.48476620600304 no 1756 0.493521289777699 559 25238761
SGTC_193 1273-0060 1.558 µM -0.0164190528186746 0.484695361046839 no 1757 0.493450039923296 562 2847393 YHR072W ERG7
SGTC_614 0462-0418 107 µM -0.0165940752551407 0.484625943716221 no 1758 0.493380225585147 549 5188303
SGTC_1333 1482-0047 286 µM -0.01669016265724 0.484587833766191 no 1759 0.493341897565884 554 3811116
SGTC_1968 st069590 43.6 µM -0.0170105837086169 0.484460750173197 no 1760 0.493214086207858 554 6384066
SGTC_991 3996-0057 64.7 µM -0.019730579436219 0.483382025651335 no 1761 0.492129148330923 563 715343
SGTC_920 mycophenolic acid 780.421 nM -0.0204675246879128 0.483089780761136 no 1762 0.491835209095923 558 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2753 fluvastatin 17.09 µM -0.0206745715913172 0.483007675340641 no 1763 0.491752626807216 562 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1397 3532-0190 20.1 µM -0.020934211514501 0.482904714930355 no 1764 0.491649067878222 557 5322280
SGTC_2248 tofa 1.1 µM -0.020956066889806 0.482896048216474 no 1765 0.491640350757265 556 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1096 rimcazole 32.2 µM -0.022350772748588 0.48234299674564 no 1766 0.49108407409272 573 18528119 A dopamine reuptake inhibitor.
SGTC_1363 1636-0063 10.4 µM -0.0235247697029839 0.481877490655211 no 1767 0.490615840292217 556 6072185
SGTC_1790 st045711 43.5 µM -0.0238557189713728 0.481746269112669 no 1768 0.490483847681142 559 585119
SGTC_1798 st045719 60.953 µM -0.0252347275525488 0.481199513003059 no 1769 0.489933868593991 556 3980186
SGTC_1231 0242-0792 125 µM -0.0257154910057434 0.481008905803857 no 1770 0.489742133953669 558 3707635
SGTC_1093 fluphenazine 7.97 µM -0.0260023992200782 0.4808951580187 no 1771 0.489627712399156 560 6602611 An atypical antipsychotic.
SGTC_1048 3161-0300 24.5 µM -0.0264241425526981 0.480727956256361 no 1772 0.489459518949321 557 2165101
SGTC_73 0327-0325 16.231 µM -0.0290719929299046 0.479678284460536 no 1773 0.488403586378706 566 53298
SGTC_2638 epoxomicin 18 µM -0.0294611067453272 0.479524042053867 no 1774 0.488248418893932 564 9915668 A protesome inhibitor.
SGTC_209 4077-0173 175.592 µM -0.0294809056923803 0.47951619395056 no 1775 0.488240523686242 550 15993494
SGTC_902 1120-0002 2.07 µM -0.0304299219944328 0.479140022810233 no 1776 0.487862090799842 561 3280475
SGTC_3086 9117350 49.47 µM -0.0331823865275289 0.478049107035502 no 1777 0.486764571951277 566 2679265
SGTC_2264 7948757 110.76 µM -0.0331888718321163 0.478046536831488 no 1778 0.486761986113341 565 2971411
SGTC_1756 st041558 35.5 µM -0.0358326318978898 0.47699886025619 no 1779 0.485707906637703 573 3955792
SGTC_56 0957-0365 83.25 µM -0.0364309921131344 0.4767617622108 no 1780 0.485469351221306 563 6752360
SGTC_1140 3229-1848 2.98 µM -0.0371527736811443 0.476475769860318 no 1781 0.48518159686706 569 2849525
SGTC_2114 5491910 81.25 µM -0.0390974774804566 0.475705278328105 no 1782 0.484406336056085 567 2849228
SGTC_2155 5570423 76 µM -0.039572910277514 0.475516925589421 no 1783 0.484216812491239 571 797402
SGTC_3056 9094900 49.47 µM -0.0397555490702459 0.475444570828527 no 1784 0.484144007447717 569 25236784
SGTC_861 0443-0273 110 µM -0.0400397014877312 0.475332001720303 no 1785 0.484030737223503 580 6149169
SGTC_1426 4048-4480 71.7 µM -0.0401273609338629 0.475297275171226 no 1786 0.483995794246711 574 14224343
SGTC_2398 5228213 48.84 µM -0.0407775100088414 0.475039722565302 no 1787 0.483736634427974 559 80771 YMR134W ERG29
SGTC_1139 k015-0024 46.9 µM -0.0419895326511146 0.474559615087399 no 1788 0.483253521246695 572 2766652
SGTC_375 3970-0961 9.27 µM -0.0424078445702592 0.474393921541207 no 1789 0.483086787456949 565 2898222
SGTC_3088 9117578 49.47 µM -0.0424872357386253 0.474362475161601 no 1790 0.483055143484006 562 678341
SGTC_487 nimodipine 119 µM -0.042866031057378 0.474212438743621 no 1791 0.482904163568746 567 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2518 prenyletin 46.28 µM -0.0430082495508776 0.47415610859649 no 1792 0.482847478874667 558 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3252 9135871 49.47 µM -0.0431816844840341 0.474087414887264 no 1793 0.482778352566697 578 17682838
SGTC_2942 9052777 62.25 µM -0.0434733358861675 0.473971900009231 no 1794 0.482662109652733 567 6469503
SGTC_3021 9087658 49.47 µM -0.0434858075050809 0.473966960402162 no 1795 0.482657138897404 564 25237042
SGTC_297 0986-0032 24 µM -0.0444470639425527 0.473586249749097 no 1796 0.48227402354601 564 2847425
SGTC_1970 st070122 35.8 µM -0.0449160890016227 0.473400498650263 no 1797 0.482087096309066 577 102928
SGTC_1360 1598-0022 39.8 µM -0.045391710508222 0.473212141022936 no 1798 0.48189754411751 581 761525
SGTC_438 sphingosine 6.67 µM -0.0455331277831873 0.473156137512808 no 1799 0.481841185059838 569 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_311 1315-0136 58 µM -0.045969170724023 0.472983460856394 no 1800 0.481667411060305 579 6759207
SGTC_954 1189-0853 2.85 µM -0.0471173799924963 0.47252878473981 no 1801 0.481209837745133 573 2828194
SGTC_838 0109-0203 71.4 µM -0.047304098547113 0.472454849959387 no 1802 0.481135430786611 572 759422
SGTC_3141 9094609 49.47 µM -0.0478144826822334 0.47225275845639 no 1803 0.480932047123529 582 25236309 YDL196W YDL196W
SGTC_2641 levomentholum 100 µM -0.0481165129606487 0.472133170026113 no 1804 0.480811693004325 564 16666
SGTC_2629 bisabolol 100 µM -0.0483052004690478 0.472058460767852 no 1805 0.480736505009574 573 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2928 9011484 9.79 µM -0.0491385205340571 0.471728526374756 no 1806 0.480404452762195 584 2994751
SGTC_3009 9080819 71.4286 µM -0.0493195559053834 0.471656852036451 no 1807 0.480332317561169 575 17027216
SGTC_323 4013-0906 34.3 µM -0.0504132148161513 0.471223877370328 no 1808 0.479896552938414 564 2910086
SGTC_199 4063-0024 41.6 µM -0.0511419623089445 0.470935388350946 no 1809 0.479606199318194 566 306215
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0542619002559932 0.469700473875888 no 1810 0.478363252000531 596 689007
SGTC_1935 st074532 41.6 µM -0.0545456325570019 0.469588182993847 no 1811 0.478250226578164 595 2829742
SGTC_283 0987-0079 11.7 µM -0.055441086409005 0.469233810967906 no 1812 0.47789353196669 571 411556
SGTC_3060 1327-0027 12.5 µM -0.0555718964391852 0.469182045492271 no 1813 0.477841426644327 563 16000455 YPR107C YTH1
SGTC_537 1334-0398 209 µM -0.055830589631457 0.469079674325668 no 1814 0.47773838296974 596 5846986
SGTC_517 1365-0151 113 µM -0.0563874022886075 0.468859337004574 no 1815 0.477516596252944 599 768657
SGTC_1077 5-fluorocytosine 377 nM -0.0570566210724371 0.468594531882173 no 1816 0.477250045733325 578 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2884 9058502 51.95 µM -0.0570733841446432 0.468587899031371 no 1817 0.477243369114846 592 6471554
SGTC_530 4358-1714 28 µM -0.0576049210766454 0.468377583812079 no 1818 0.477031664866103 576 1564641
SGTC_2921 7974240 10.71 µM -0.0582746832671434 0.468112589057471 no 1819 0.476764916531292 579 2979074 YDR527W RBA50
SGTC_206 4546-0025 72.014 µM -0.0583825725173769 0.468069903455181 no 1820 0.476721948104211 583 6620745 YIL048W NEO1
SGTC_2754 granisetron 64.02 µM -0.0584141199598923 0.468057422006844 no 1821 0.476709383938038 582 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1626 st003712 1.76 µM -0.0586065037136078 0.467981307867723 no 1822 0.476632765187531 593 24207035
SGTC_2493 resveratrol 26.09 µM -0.05916548694232 0.467760160048356 no 1823 0.476410149448006 572 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_524 r073-0010 27.8 µM -0.0593595412209007 0.467683389619954 no 1824 0.476332868817478 592 2772106
SGTC_2165 5727197 32.143 µM -0.0599570258240462 0.467447024401812 no 1825 0.476094930751873 595 1361712
SGTC_658 3253-0951 102 µM -0.0605894460514558 0.467196851138204 no 1826 0.475843089456543 580 1184878
SGTC_2265 7929201 200 µM -0.0606500101072956 0.467172893842275 no 1827 0.475818972247108 579 1265108
SGTC_151 3013-0144 2.285 µM -0.0616213996869289 0.466788658018406 no 1828 0.475432167419996 569 906558 YHR107C CDC12
SGTC_1844 rapamycin 4 nM -0.0636734669520297 0.465977059339601 no 1829 0.474615116084041 592 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1071 trifluoperazine 6.31 µM -0.0645702684086664 0.465622415933538 no 1830 0.474258078832466 595 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2769 toremifene 3.73 µM -0.0647184363067384 0.465563825018291 no 1831 0.474199091772518 574 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1571 st070080 73.4 µM -0.064870245072222 0.465503795147358 no 1832 0.474138655835033 580 4315245
SGTC_3301 9125354 19.7965 µM -0.0649724040969973 0.465463398757945 no 1833 0.474097986078122 576 41905162
SGTC_2786 7743617 45.45 µM -0.0649740800990775 0.465462736025212 no 1834 0.474097318859856 588 583674
SGTC_301 4119-0100 24.5 µM -0.0653768842990394 0.465303460050332 no 1835 0.473936964177585 592 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1767 st044992 70.3 µM -0.0657273463387962 0.465164885621421 no 1836 0.473797450126714 580 9600693
SGTC_1145 3546-0597 10.2 µM -0.0658325086768544 0.46512330473454 no 1837 0.473755587092473 578 875334
SGTC_1250 0485-0349 40.2 µM -0.0660826363588822 0.465024406497292 no 1838 0.473656017404653 589 6842794 YDL195W SEC31
SGTC_1205 4161-2785 76 µM -0.0668499658771296 0.464721024808849 no 1839 0.473350572662194 624 3498106
SGTC_2558 carylophyllene oxide 100 µM -0.0681252082594416 0.464216873326725 no 1840 0.472842981839723 565 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_263 alizarin 107.927 µM -0.0682289238134148 0.464175873165932 no 1841 0.472801701369826 578 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_977 1348-1378 135 µM -0.0683387293882331 0.464132465952149 no 1842 0.472757997291378 572 X977
SGTC_3227 9130768 49.47 µM -0.0684956957865233 0.464070416346729 no 1843 0.472695523147881 576 17720899
SGTC_831 k061-1017 217 µM -0.0691212071173499 0.463823157271656 no 1844 0.472446570279821 589 1240153
SGTC_3065 9113888 49.47 µM -0.0709717971030746 0.463091717664264 no 1845 0.471710100762113 601 16648368
SGTC_585 0kpi-0023 191 µM -0.0713990913075578 0.462922848674094 no 1846 0.471540066398599 577 64601
SGTC_1661 st013063 9.66 µM -0.0735321528426925 0.462079951703242 no 1847 0.470691329525857 597 721395
SGTC_2275 7947463 200 µM -0.0735495946544176 0.462073060123264 no 1848 0.470684390040379 575 1225414
SGTC_1816 st051957 91.6 µM -0.0745420593111346 0.461680937939977 no 1849 0.470289537872901 581 674121
SGTC_1407 3909-7909 12.3 µM -0.0753256911225599 0.461371351782727 no 1850 0.469977790492924 574 4411780
SGTC_2920 7982904 15.77 µM -0.0775337806336125 0.460499137559996 no 1851 0.469099459543156 585 6456808
SGTC_1269 0831-0796 3.05 µM -0.0797400489612896 0.459627832498125 no 1852 0.468222003192854 573 927758
SGTC_2747 doxorubicin 7.63 µM -0.0803322684170403 0.459393984524005 no 1853 0.467986497325547 571 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_292 k038-0015 474 µM -0.0805344503780082 0.459314152733732 no 1854 0.467906098884081 597 46368540
SGTC_588 3970-1144 52.9 µM -0.0805974910127862 0.459289261398685 no 1855 0.467881030798564 574 1888707
SGTC_697 0508-1955 564 µM -0.0812609444612026 0.459027309233122 no 1856 0.46761721651873 574 6243113
SGTC_185 k048-0037 25.491 µM -0.0812825855683719 0.459018764946341 no 1857 0.467608611431794 579 6827589
SGTC_887 0885-0007 9.62 µM -0.0822401347952246 0.458640726807928 no 1858 0.467227879285256 587 5719458
SGTC_669 0108-0021 26.2 µM -0.0841130100178933 0.45790142859544 no 1859 0.466483290401774 642 17201
SGTC_1425 4048-4433 7.33 µM -0.0844205926149078 0.457780027386202 no 1860 0.466361017594279 582 23734946
SGTC_1608 st001473 40.5 µM -0.0846949243676165 0.457671753430654 no 1861 0.466251965618921 617 7292267
SGTC_1023 4482-3888 16 µM -0.0848772780398371 0.457599783355978 no 1862 0.466179478043092 580 3303168
SGTC_3244 9134489 49.47 µM -0.085159675796118 0.457488331325049 no 1863 0.466067224066389 606 16584271
SGTC_812 4251-0442 148 µM -0.0853376322711067 0.457418100151627 no 1864 0.465996487206252 595 5723007
SGTC_776 4476-4378 112 µM -0.0853995643899416 0.457393658726322 no 1865 0.465971869732754 591 2892008
SGTC_3153 9100258 49.47 µM -0.0858802030343712 0.457203980833166 no 1866 0.465780824524745 594 25236848
SGTC_165 k038-0023 64.381 µM -0.085911811597333 0.457191507259261 no 1867 0.4657682609659 588 46368543
SGTC_1024 4507-0395 26 µM -0.0860109529940175 0.457152383718889 no 1868 0.46572885513226 583 4201836
SGTC_3337 9144342 33.5465 µM -0.0880022859569867 0.456366645070971 no 1869 0.464937429631301 581 17682949
SGTC_1680 diphenhydramine 100 µM -0.0882856469753098 0.456254850488615 no 1870 0.464824823231371 574 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1443 4112-3303 14 µM -0.0888462822911308 0.456033672933099 no 1871 0.464602037576128 581 704433
SGTC_2859 9028643 45.46 µM -0.089930674764899 0.455605905430161 no 1872 0.464171152484723 597 17151580
SGTC_219 mitoxanthrone 164.414 µM -0.0907952356361173 0.455264893205103 no 1873 0.463827647913703 595 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1399 3562-5772 25 µM -0.090935815510522 0.455209446828086 no 1874 0.463771795707756 574 23847490
SGTC_1195 1502-0147 41.1 µM -0.0912249979222924 0.455095392584832 no 1875 0.463656906148263 593 817940
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0912690712430713 0.455078010285237 no 1876 0.463639396482033 585 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_5 0352-0601 109.883 µM -0.0913458702101891 0.455047721358218 no 1877 0.463608885577954 604 762456
SGTC_1555 citronellol 128 µM -0.0923429837442208 0.454654491169379 no 1878 0.463212769075749 581 8842 A terpine precursor.
SGTC_1719 st032227 49.2 µM -0.0940562155313886 0.453978950459813 no 1879 0.462532250538258 587 3125804
SGTC_3135 9127742 49.47 µM -0.0944955019168829 0.453805757762285 no 1880 0.462357777704475 592 3643468
SGTC_1367 1812-0510 76.9 µM -0.0946746927021237 0.453735112667785 no 1881 0.462286609982489 592 1142582 YDR527W RBA50
SGTC_992 3909-8734 162 µM -0.0962829956982364 0.453101112838041 no 1882 0.461647907902243 619 4288319
SGTC_934 2950-0684 338 µM -0.0965432143275658 0.452998544747789 no 1883 0.461544577062159 620 1121253
SGTC_3336 9143619 71.43 µM -0.0971569420610339 0.452756649512024 no 1884 0.461300880736942 596 45595730
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0972853215236708 0.452706052122078 no 1885 0.46124990621582 594 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2740 felodipine 17.08 µM -0.097465245868715 0.452635140964413 no 1886 0.461178466286319 581 3333 L-type calcium channel blocker
SGTC_1827 berberine 7.24 µM -0.0982866752968604 0.452311421277587 no 1887 0.460852329261425 580 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_37 0566-0070 1.56 µM -0.0984219474548402 0.452258114484913 no 1888 0.460798623868958 612 1626686
SGTC_235 0330-0087 5 mM -0.100271620652955 0.451529299231676 no 1889 0.460064343678459 586 46494818 YHR062C RPP1
SGTC_492 tmb-8 126 µM -0.100542079631087 0.451422745588559 no 1890 0.45995698867514 617 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_858 0438-0351 2.77 µM -0.100736146066353 0.451346290731461 no 1891 0.459879958448392 601 2799119
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.100901955336063 0.45128096956161 no 1892 0.459814145449176 601 75037 A free radical scavenger.
SGTC_19 0279-0214 38.434 µM -0.101955313859165 0.450866025992732 no 1893 0.459396072277507 580 3566274 YBR002C RER2
SGTC_1748 st037455 53.6035 µM -0.102916866934798 0.4504872936887 no 1894 0.459014475453488 596 580690
SGTC_706 4262-0057 46.9 µM -0.103046307331365 0.450436313708809 no 1895 0.458963109304295 605 883298
SGTC_245 methotrexate 289.6 µM -0.104285234211978 0.449948405000495 no 1896 0.458471497704922 587 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1668 st014914 51.6 µM -0.104696514236409 0.449786453207226 no 1897 0.458308313999131 584 2839556
SGTC_305 1682-2595 20.8 µM -0.104718380812862 0.449777842929897 no 1898 0.458299638187132 613 226033
SGTC_1868 st057644 42.7 µM -0.105119660806059 0.449619837393712 no 1899 0.458140429334198 595 688665
SGTC_1772 st048439 82.2 µM -0.106862741828996 0.448933585579839 no 1900 0.457448935798076 586 2927068 YDL195W SEC31
SGTC_1326 1431-2094 10.8 µM -0.106946592093256 0.448900577525843 no 1901 0.457415674988895 624 616278
SGTC_229 benomyl 22.8748 µM -0.107933695121036 0.448512026389719 no 1902 0.457024144200996 601 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1171 0368-0077 21.4 µM -0.109872322131247 0.447749073091686 no 1903 0.456255316680106 583 3239779
SGTC_1155 4088-0394 48.2 µM -0.111590438515537 0.447073063957978 no 1904 0.455574076814073 599 2326248
SGTC_476 mead acid 10 µM -0.111723907383317 0.447020555780637 no 1905 0.455521161327153 596 5312531 An omega 9 fatty acid.
SGTC_3232 9132874 49.47 µM -0.112057585950269 0.446889286885554 no 1906 0.455388873527733 615 3784940
SGTC_1630 st005209 31.3 µM -0.112394331510097 0.446756817337025 no 1907 0.455255374825184 584 3367314
SGTC_1482 3346-2049 8.48 µM -0.113559057291447 0.44629868140354 no 1908 0.454793672437165 608 3826804
SGTC_276 colchicine 750 µM -0.114624280623816 0.445879746729448 no 1909 0.454371466700201 585 2833 A microtubule depolymerizer.
SGTC_2223 6903751 107.57 µM -0.114751856615192 0.445829577249225 no 1910 0.454320904867995 593 5598863
SGTC_2073 5212005 126 µM -0.114890299984508 0.445775135135073 no 1911 0.454266036836084 599 691789
SGTC_1038 k292-0204 154 µM -0.114998901661639 0.445732428822216 no 1912 0.454222996307963 584 4454212
SGTC_399 oxolinic acid 75 µM -0.115213527995148 0.445648031431336 no 1913 0.454137938146334 601 4628 A DNA gyrase inhibitor.
SGTC_2090 5301565 104.445 µM -0.115805201434893 0.445415380786564 no 1914 0.453903464052819 617 2056344
SGTC_2198 6589944 200 µM -0.116282435679599 0.445227742223358 no 1915 0.453714352735365 593 5290268
SGTC_2540 epiandrosterone 100 µM -0.116555094672505 0.445120543892487 no 1916 0.453606312176306 593 441302 A steroid.
SGTC_505 gw-5074 63.9 µM -0.117173352005078 0.444877485349994 no 1917 0.45336134172551 591 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_124 0136-0217 7.121 µM -0.117543150882054 0.444732114399511 no 1918 0.453214825780281 614 3976905
SGTC_166 k072-0058 166.424 µM -0.117686644101559 0.444675708046894 no 1919 0.453157974848107 592 5846229
SGTC_3133 9127736 49.47 µM -0.119481925703388 0.443970088315628 no 1920 0.452446779325994 617 27243420
SGTC_2717 st081029 62.2815 µM -0.120019363310886 0.443758887600653 no 1921 0.45223390456405 613 5292846
SGTC_1879 gemcitabine 100 µM -0.120346836775164 0.443630205830109 no 1922 0.452104201657572 595 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2748 diazoxide 86.69 µM -0.120374440814246 0.443619359003964 no 1923 0.452093268717788 588 3019 A potassium channel activatior.
SGTC_149 3970-0822 46.1 µM -0.120402184828997 0.443608457217861 no 1924 0.45208228037542 608 3114250 YBL034C STU1
SGTC_510 ag-490 170 µM -0.120433556583514 0.443596129992185 no 1925 0.452069855268399 598 5328779
SGTC_2229 7354935 190 µM -0.120566794771437 0.443543775951015 no 1926 0.452017085432744 602 318112
SGTC_2704 st078022 71.1 µM -0.122478253880943 0.442792804335563 no 1927 0.451260133604813 635 54697681
SGTC_41 0478-0632 82.643 µM -0.125371469419282 0.441656513246682 no 1928 0.450114736991358 605 3750424
SGTC_1958 st076513 41.9 µM -0.126407183204568 0.441249859753342 no 1929 0.449704808195003 632 732122 YGL099W LSG1
SGTC_1917 st066507 28.5 µM -0.126408184150396 0.441249466780718 no 1930 0.449704412053025 611 3156428
SGTC_2237 6667747 47.222 µM -0.126445252941912 0.441234913566049 no 1931 0.449689741459853 630 729940 YDL015C TSC13
SGTC_2437 5741531 144.16 µM -0.12798916821896 0.440628842841268 no 1932 0.449078772523966 607 2262990
SGTC_676 falcarinol 140 µM -0.129724366518732 0.439947849148919 no 1933 0.448392251884285 612 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_944 3370-0224 231 µM -0.129728547494321 0.439946208502324 no 1934 0.448390597892543 613 4580514
SGTC_617 3770-0098 35 µM -0.13004534717971 0.439821896899703 no 1935 0.448265274715151 615 5962639
SGTC_3149 9097855 49.47 µM -0.130565936258321 0.439617631611713 no 1936 0.448059345459747 591 25236625 YMR079W SEC14
SGTC_3076 9116187 49.47 µM -0.133625429679911 0.438417494468414 no 1937 0.446849387272993 645 27241210
SGTC_1998 st075797 76.8 µM -0.134586315667501 0.438040687261529 no 1938 0.446469480837862 616 24208315
SGTC_451 chloral hydrate 100 µM -0.135731549073653 0.437591662421697 no 1939 0.446016752980751 631 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2305 7443522 69.23 µM -0.135833789965227 0.437551579557643 no 1940 0.445976339043348 609 5415886
SGTC_3353 9151644 39.2805 µM -0.136735356577837 0.437198154128485 no 1941 0.445619990743873 623 4909158
SGTC_3300 9124615 50.48 µM -0.136859772042719 0.437149385632913 no 1942 0.445570818408917 623 24824903
SGTC_1546 5-methoxyflavanone 78.7 µM -0.138036927943146 0.436688010277285 no 1943 0.445105616306537 621 147795
SGTC_3231 9132313 49.47 µM -0.138337146435858 0.436570356175147 no 1944 0.444986984557037 630 4905967
SGTC_1422 4031-0024 15.5 µM -0.138612509352959 0.436462447780028 no 1945 0.444878178853975 624 782427
SGTC_2325 6158266 200 µM -0.138700374690465 0.436428016369473 no 1946 0.444843461001026 598 3623240
SGTC_1105 epirubicin 18.1 µM -0.139142615331223 0.436254724757023 no 1947 0.444668726787782 619 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_904 1141-0088 396 µM -0.139899233028825 0.435958273157589 no 1948 0.444369803642203 641 1378119
SGTC_1980 st071811 45.7 µM -0.140448789712491 0.435742973013788 no 1949 0.444152705612517 638 4974850
SGTC_1923 st058458 19.1 µM -0.140492573733942 0.435725820540246 no 1950 0.444135409800292 659 3534982
SGTC_2421 5690543 90.72 µM -0.141492838354116 0.435333997970871 no 1951 0.443740308646168 624 3397993
SGTC_1736 st036774 51 µM -0.142619468843515 0.434892751535374 no 1952 0.443295360375873 655 1272247
SGTC_3327 9140648 26.9345 µM -0.143086233515901 0.434709966207761 no 1953 0.443111038564185 628 8029710
SGTC_744 1594-0068 283 µM -0.143142225876984 0.434688040501935 no 1954 0.443088928433677 604 668392
SGTC_1939 st074455 53.6 µM -0.143147409934896 0.434686010518598 no 1955 0.443086881374168 597 1644229
SGTC_2947 9072639 7.68 µM -0.144029679079889 0.434340555001108 no 1956 0.442738516728875 629 16488146
SGTC_1789 tunicamycin 25 nM -0.14487900750658 0.434008044890775 no 1957 0.442403200564946 616 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1512 0259-0544 12.2 µM -0.145060301629857 0.433937074700539 no 1958 0.442331630702632 604 18476
SGTC_154 3389-1638 511.116 µM -0.145867970952042 0.433620926843721 no 1959 0.442012808288344 678 5238686
SGTC_354 2783-3500 4.88 µM -0.146751427899823 0.433275161897499 no 1960 0.441664112201217 607 6740761
SGTC_1129 3453-1384 223 µM -0.147048825042372 0.433158778898951 no 1961 0.441546741176881 681 1084452
SGTC_2745 rifampicin 24.3 µM -0.147769546581632 0.43287675676484 no 1962 0.441262321876351 597 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1625 st003711 30.1 µM -0.147977177122224 0.432795516177314 no 1963 0.44118038997322 623 24207034 YER133W GLC7
SGTC_1688 st021091 57.6 µM -0.148225262382209 0.432698450404548 no 1964 0.441082497765119 641 3656366
SGTC_215 1287-0124 461.5 µM -0.148276691215553 0.432678328880907 no 1965 0.441062204861169 620 5560863
SGTC_1111 tnp00062 510.699 nM -0.148640557939959 0.43253597106722 no 1966 0.440918633939805 611 676306
SGTC_2539 epi(13)torulosol 80 µM -0.149491659767014 0.432203023499015 no 1967 0.440582844981596 644 6708597
SGTC_2673 kobusone 100 µM -0.149536162978221 0.432185615346481 no 1968 0.440565288106608 602 6710676 An epoxy ketone and protein crosslinker.
SGTC_3066 9117245 49.47 µM -0.149568239199734 0.432173068294071 no 1969 0.440552633851521 629 17176980
SGTC_1148 3909-7663 27.7 µM -0.152056270639139 0.431200050202073 no 1970 0.439571277019261 661 4084526
SGTC_2216 7189485 200 µM -0.152828742606222 0.43089803688768 no 1971 0.439266665333763 620 731273
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.153966703588962 0.430453202009931 no 1972 0.43881799458864 610 641818 YHR062C RPP1
SGTC_2496 diffractaic acid 79.83 µM -0.154888256602728 0.430093026771884 no 1973 0.438454705896164 607 94870 An apoptosis inducer which activates caspases.
SGTC_1036 k216-0215 33.5 µM -0.155149365284413 0.429990986903049 no 1974 0.438351782727588 613 622330
SGTC_1122 capsaicin 818.572 nM -0.155355749058071 0.429910336542222 no 1975 0.438270433836571 614 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1843 st055809 45.5 µM -0.156055491407045 0.42963691399785 no 1976 0.437994640578189 622 16413835
SGTC_2126 5251174 33.877 µM -0.156581188134486 0.429431521530939 no 1977 0.437787464670799 616 790722
SGTC_2118 5526350 200 µM -0.157552947357415 0.42905190043947 no 1978 0.437404541466819 631 743594
SGTC_1405 3909-7894 12 µM -0.157590641362498 0.429037176466109 no 1979 0.437389689265415 607 7104060
SGTC_188 3229-0966 278.469 µM -0.158414310941164 0.428715460630623 no 1980 0.437065168832766 618 5722370
SGTC_2089 5281248 129.67 µM -0.158660065006874 0.428619481091091 no 1981 0.436968351527924 610 2737878
SGTC_2307 7538926 6.34 µM -0.159809860923427 0.428170483111936 no 1982 0.436515428013845 615 96582
SGTC_980 1473-0395 201 µM -0.161094717027653 0.427668853839853 no 1983 0.436009400551525 602 768876
SGTC_884 0851-0618 334 µM -0.163338407262848 0.426793160478994 no 1984 0.435125997660474 656 9642473
SGTC_3193 9111931 49.47 µM -0.163460531008948 0.426745506923477 no 1985 0.435077923414071 633 17087244
SGTC_278 4092-0821 23.9 µM -0.164284075402872 0.426424181985821 no 1986 0.434753758678269 651 877900
SGTC_1714 st033236 13.627 µM -0.165671760862047 0.42588285490289 no 1987 0.434207635237075 651 2916566
SGTC_1907 st060210 83.7 µM -0.166289256166501 0.425642018830482 no 1988 0.433964660335794 646 688793
SGTC_3043 9092303 49.47 µM -0.166439730432351 0.425583334922222 no 1989 0.433905454804468 628 25236084
SGTC_1483 3453-0561 55.9 µM -0.166641534945921 0.425504635165377 no 1990 0.433826055226879 624 4546991
SGTC_791 1348-1292 225 µM -0.167950206555102 0.424994351363262 no 1991 0.433311225969735 618 5437054
SGTC_2677 mitomycin C 100 µM -0.168089329742457 0.424940111125677 no 1992 0.433256501775173 619 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2374 9071832 200 µM -0.168667297553028 0.4247147928749 no 1993 0.433029171480832 607 17381698
SGTC_967 1306-0166 352 µM -0.168739711004343 0.424686564536534 no 1994 0.433000690882243 605 4437607
SGTC_1828 st055811 49 µM -0.169413766749708 0.424423821495316 no 1995 0.432735597859837 663 5877589
SGTC_1743 st037606 46.3785 µM -0.169597204874943 0.424352324180235 no 1996 0.432663460445753 622 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1945 st075991 56.6 µM -0.169952143086027 0.424213989621069 no 1997 0.43252388665006 625 1084980
SGTC_728 3030-5151 22.5 µM -0.171128884710467 0.423755430098922 no 1998 0.432061212077436 620 3125388
SGTC_2451 5856223 45.7 µM -0.171199805116592 0.423727796714468 no 1999 0.432033330363546 601 2179896
SGTC_3264 9137442 49.47 µM -0.173508961889072 0.422828263939136 no 2000 0.431125692075746 642 17015726
SGTC_3160 9100216 49.47 µM -0.175387953876511 0.422096598579564 no 2001 0.430387402647385 621 17191039
SGTC_318 1488-0629 67.2 µM -0.176506759477861 0.421661071588649 no 2002 0.429947919378456 639 3662576
SGTC_3002 9075603 71.4286 µM -0.177638970542562 0.421220423676174 no 2003 0.429503258593895 618 20105405
SGTC_1371 2421-0008 32.7 µM -0.179025405025016 0.420680968370076 no 2004 0.42895887680709 647 2827552
SGTC_1338 1486-1223 76 µM -0.179366256053155 0.420548367563976 no 2005 0.428825062723126 637 3444526
SGTC_417 st075190 100 µM -0.179371615194633 0.420546282776495 no 2006 0.428822958852824 622 222757
SGTC_1949 st076024 69.1 µM -0.180059983551923 0.420278515572437 no 2007 0.428552738793624 616 2921930
SGTC_137 0438-0332 85.389 µM -0.181298958881705 0.419796661760091 no 2008 0.428066461589915 660 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1909 st060837 51.5 µM -0.181937169808313 0.419548499996712 no 2009 0.427816016993414 650 678937
SGTC_1788 fluconazole 20 µM -0.183589996629229 0.418905964216746 no 2010 0.427167555633047 612 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1795 st049545 62.3 µM -0.18383241426512 0.418811742599631 no 2011 0.427072463278947 605 5291882
SGTC_2621 lithochol-11-enic acid 100 µM -0.18446684609617 0.418565177013844 no 2012 0.426823616900621 661 6708711
SGTC_2697 mebhydrolin 72.4 µM -0.185348053533528 0.418222757653132 no 2013 0.426478024824777 632 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_526 4469-0568 170 µM -0.18627844782155 0.417861292538618 no 2014 0.426113203901575 632 2901964
SGTC_2235 salicylic acid 500 µM -0.186773149480431 0.417669125490142 no 2015 0.425919250022959 621 338 A COX inhibitor and kinase inhibitor.
SGTC_441 propafenone 146 µM -0.187247999551792 0.417484688289153 no 2016 0.425733096058873 614 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1258 0671-0043 57.1 µM -0.187607884319295 0.417344917017417 no 2017 0.425592022600679 670 4298767
SGTC_2722 naftopidil 47.16 µM -0.188880694229856 0.416850669743668 no 2018 0.425093162494114 661 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_721 1187-1332 279 µM -0.189237732911891 0.416712050928859 no 2019 0.424953247661712 649 25730
SGTC_2600 tangeritin 87.95 µM -0.189320306356347 0.41667999359901 no 2020 0.424920890469344 656 68077 A bioactive flavone.
SGTC_771 0250-0039 27.3 µM -0.190548033477625 0.416203420932939 no 2021 0.424439853665774 644 3005115
SGTC_1637 st007924 17.4 µM -0.192554155172345 0.415424960522499 no 2022 0.423654075888424 606 683336
SGTC_2168 5727979 200 µM -0.192556537171034 0.415424036402501 no 2023 0.423653143063173 623 695210
SGTC_2029 5175081 200 µM -0.193324161997724 0.415126253138764 no 2024 0.42335255235654 639 1380876
SGTC_2808 7946468 45.46 µM -0.194239447570251 0.414771251850774 no 2025 0.42299419816578 675 2970879
SGTC_948 3448-0295 75.3 µM -0.194298498782808 0.414748350722829 no 2026 0.422971080517363 641 678569
SGTC_1278 0874-0585 172 µM -0.196623816010683 0.41384678176684 no 2027 0.422060965969018 625 766306
SGTC_2899 9053889 58.44 µM -0.197428064268411 0.413535065087568 no 2028 0.42174628484225 632 6470052
SGTC_2341 7987486 176.74 µM -0.197799111591411 0.413391270089036 no 2029 0.421601120643639 628 1258686
SGTC_610 4215-0184 155 µM -0.198348432381393 0.413178408651624 no 2030 0.42138623039359 638 5605015
SGTC_2262 9014885 67.46 µM -0.198499441897065 0.413119897035052 no 2031 0.421327160682578 637 6457424
SGTC_3057 9095946 49.47 µM -0.199251782126853 0.412828416749669 no 2032 0.421032897559225 628 24540043
SGTC_962 1254-0300 21.5 µM -0.199896642049263 0.412578615960068 no 2033 0.420780708350074 632 7340576
SGTC_598 3937-0236 20.2 µM -0.200386929105378 0.412388716083426 no 2034 0.420588990619238 628 1379313
SGTC_2093 5331342 194.4 µM -0.200785301856542 0.412234431909905 no 2035 0.420433228153192 626 33839
SGTC_1124 fisetin 1.16336 µM -0.201802839656069 0.411840415422883 no 2036 0.420035430749401 661 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2974 9094440 9.66 µM -0.202101097409388 0.41172493926819 no 2037 0.419918844979888 638 25236134
SGTC_1130 3454-2858 15.9 µM -0.202208213318086 0.411683469174756 no 2038 0.419876976230067 637 715628 YIL048W NEO1
SGTC_1233 0325-0408 14.2 µM -0.203178458355842 0.41130788226551 no 2039 0.419497774705511 660 12874
SGTC_2175 5807670 165.306 µM -0.204636934215059 0.410743451668915 no 2040 0.418927898334165 629 241186
SGTC_794 k038-0031 316 µM -0.205242590018908 0.410509116921084 no 2041 0.418691297815579 626 6624242
SGTC_1520 flindersine 88 µM -0.206299890101204 0.410100112745451 no 2042 0.418278332186824 660 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_806 3966-4455 5.86 µM -0.206677190831238 0.409954182018465 no 2043 0.418130985936079 682 714982
SGTC_1504 k297-0033 30 µM -0.207090106004147 0.409794490785709 no 2044 0.417969744439902 638 4388117
SGTC_3344 9148862 3.898 µM -0.21061291339158 0.408432687626243 no 2045 0.416594667452087 676 4905352
SGTC_3174 9107204 49.47 µM -0.211590184528485 0.408055101369591 no 2046 0.41621338378536 656 3938802
SGTC_3134 9127454 49.47 µM -0.213486040957631 0.407322846924409 no 2047 0.415473937934088 639 24262820
SGTC_2214 7179297 48.276 µM -0.214084161445 0.407091896288512 no 2048 0.415240713404613 631 769744
SGTC_2180 6301957 200 µM -0.215059206692786 0.406715473999491 no 2049 0.414860579031712 670 845462
SGTC_1523 st012844 44.7 µM -0.215859050677466 0.406406753569241 no 2050 0.414548808696142 664 4274103
SGTC_2449 5812982 45.77 µM -0.221478497551781 0.404239433404893 no 2051 0.412359938681348 629 776185
SGTC_2479 5617353 43.85 µM -0.221722550918192 0.40414537242903 no 2052 0.412264936962512 650 2731746
SGTC_1735 st034310 56.75 µM -0.221880834315412 0.40408437114834 no 2053 0.412203325338759 618 871153
SGTC_3138 9097216 49.47 µM -0.222051639639123 0.404018546623796 no 2054 0.412136841997387 639 25237486
SGTC_814 3342-0569 96 µM -0.222161755844964 0.403976111759001 no 2055 0.412093982297038 642 4346283
SGTC_458 nppb 133 µM -0.222220002682487 0.40395366595875 no 2056 0.412071311743696 647 4549 A chloride channel blocker.
SGTC_1249 0481-0015 10.2 µM -0.22297522088057 0.403662666338884 no 2057 0.411777395950856 643 4227577
SGTC_486 niguldipine 82 µM -0.223477026133119 0.403469340915237 no 2058 0.411582130756244 625 1236 A calcium channel blocker.
SGTC_2794 7785382 27.27 µM -0.22605993703099 0.402474623139548 no 2059 0.410577401824344 676 2205081
SGTC_2472 5377652 49.4 µM -0.227436973299902 0.401944563297621 no 2060 0.410041986475672 679 1610903
SGTC_2731 amoxapine 43.43 µM -0.227922839174648 0.401757582891558 no 2061 0.409853113444693 641 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3204 9114183 49.47 µM -0.22939428418358 0.401191449992522 no 2062 0.409281239146628 643 17027248
SGTC_666 0272-0154 136 µM -0.229896430784316 0.400998298391944 no 2063 0.40908612493805 638 6870312
SGTC_3096 9117468 49.47 µM -0.23003396152227 0.400945401163343 no 2064 0.409032689887328 664 41316311
SGTC_2652 actinonin 100 µM -0.230674244247719 0.4006991588166 no 2065 0.40878394202519 633 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2645 abamectin 100 µM -0.231130189091166 0.40052383387337 no 2066 0.408606831249775 639 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3260 9137109 49.47 µM -0.231257150682423 0.400475016766773 no 2067 0.408557516618407 651 17478346
SGTC_113 0099-0221 2.5 µM -0.234061196873451 0.399397250362723 no 2068 0.407468734821587 632 89219
SGTC_3011 9081274 71.4286 µM -0.235305950081946 0.398919060674561 no 2069 0.406985638634418 636 6625322
SGTC_2692 st077426 47.7 µM -0.235372775408588 0.398893393056362 no 2070 0.406959707319493 690 25238571
SGTC_1810 st050138 53 µM -0.236062776759049 0.398628389016045 no 2071 0.406691978776511 682 3444541
SGTC_890 0929-0006 47.2 µM -0.238382358999627 0.397737866409644 no 2072 0.405792274289538 660 1378169
SGTC_2627 acetyl isogambogic acid 100 µM -0.238739953068606 0.397600627920051 no 2073 0.405653617157939 668 6857789 A caspase activator and apoptosis inducer.
SGTC_1832 st054113 55 µM -0.2387481166813 0.397597495012976 no 2074 0.405650451854536 665 1251267
SGTC_2489 cantharidin 73.42 µM -0.239071589791037 0.397473362742253 no 2075 0.40552503556865 653 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3266 9136860 49.47 µM -0.239295684843486 0.397387372723513 no 2076 0.405438155611604 663 4871271 YPR165W RHO1
SGTC_1094 duloxetine 25.4 µM -0.240378697746285 0.396971868088596 no 2077 0.405018345437604 645 60834 A selective serotonin reuptake inhibitor.
SGTC_3023 9089636 49.47 µM -0.240477093686158 0.396934123661591 no 2078 0.404980209456529 630 17249241
SGTC_2691 st077356 60.2 µM -0.240643445569283 0.396870313707297 no 2079 0.404915737382665 669 2839272
SGTC_3014 9081533 49.47 µM -0.24073856084155 0.396833830232126 no 2080 0.404878875245349 689 21367265
SGTC_34 0469-0683 81.75 µM -0.242892383587813 0.396007928268867 no 2081 0.404044382969249 646 3690923
SGTC_1574 spiramycin 23.7 µM -0.24350075711246 0.395774726529136 no 2082 0.40380874933314 642 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2022 5136654 200 µM -0.244516752517983 0.395385358377005 no 2083 0.403415314519562 683 1713771
SGTC_1187 1391-0724 117 µM -0.244635622515381 0.395339809679935 no 2084 0.40336928959226 663 6997986
SGTC_345 1362-0200 395 µM -0.244894033874092 0.395240796350067 no 2085 0.403269240670654 670 1419823
SGTC_660 4031-1742 102 µM -0.245840360107663 0.394878258181261 no 2086 0.402902906384596 644 6738706
SGTC_1596 piperlongumine 63 µM -0.246997909515797 0.39443492404364 no 2087 0.402454920963533 663 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2047 4141938 200 µM -0.24782808806566 0.394117055027744 no 2088 0.40213371079426 648 3807862
SGTC_1266 0828-0227 32.9 µM -0.248357628513508 0.393914334862244 no 2089 0.401928857113163 659 3913820
SGTC_2286 7945697 125 µM -0.250513487662371 0.393089320041769 no 2090 0.401095137761923 674 1245733
SGTC_374 0880-0231 82.3 µM -0.251019334851498 0.392895809324911 no 2091 0.400899580314259 673 6833587
SGTC_328 k915-0120 63.5 µM -0.25149051706409 0.392715583424858 no 2092 0.400717446470571 652 6624543
SGTC_2481 5478948 45.16 µM -0.254048515398294 0.391737558414816 no 2093 0.399729038707429 655 77792
SGTC_1334 1486-0610 236 µM -0.254778867286279 0.391458440917442 no 2094 0.399446949110756 635 3742339
SGTC_93 0109-0045 59.227 µM -0.254789192785793 0.391454495236845 no 2095 0.399442961387193 650 88733
SGTC_848 0368-0089 85.6 µM -0.255415823543321 0.391215061898766 no 2096 0.399200975291097 684 762535
SGTC_2924 9010168 62.78 µM -0.256610994984589 0.390758505581723 no 2097 0.398739543198619 657 2993929
SGTC_1990 st072050 59.8 µM -0.25674491603814 0.390707357014931 no 2098 0.398687847728794 652 17233948
SGTC_1647 st011722 22.4 µM -0.257213491525756 0.390528408521743 no 2099 0.398506984786859 675 2854783
SGTC_478 N-arachidonylglycine 10 µM -0.257385267912535 0.390462813103533 no 2100 0.398440687197671 640 5283389
SGTC_22 0964-0034 14.468 µM -0.258029097356371 0.390216984822742 no 2101 0.398192225473313 664 138402
SGTC_1438 4092-1045 4 µM -0.259186384330233 0.389775217547402 no 2102 0.397745717989126 662 1351342
SGTC_315 k915-0449 187 µM -0.261503428560976 0.388891168378291 no 2103 0.396852152937799 660 20970215 YNL149C PGA2
SGTC_2620 irigenin 100 µM -0.263141402319746 0.388266559591732 no 2104 0.396220796814943 635 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1720 st037298 9.481 µM -0.263391514056125 0.388171209827303 no 2105 0.396124415282231 719 597396
SGTC_1410 3909-8106 77.9 µM -0.263824004055967 0.388006348147909 no 2106 0.395957768559567 668 1039210
SGTC_1243 0416-0003 5.65 µM -0.265536041900794 0.387353931556187 no 2107 0.395298274306514 681 2141977
SGTC_1131 3454-3128 32.3 µM -0.266578896877674 0.386956680251872 no 2108 0.394896702831584 627 710982
SGTC_3049 9092223 49.47 µM -0.266614056672539 0.386943289007959 no 2109 0.394883165815512 695 8623917
SGTC_781 4335-2806 94.4 µM -0.26670815329596 0.386907451268804 no 2110 0.394846937914901 697 845254
SGTC_1091 telmisartan 47.6 µM -0.269091633949949 0.38599999862607 no 2111 0.393929584108146 687 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2199 6590217 200 µM -0.269602027636027 0.385805759437984 no 2112 0.393733220131555 660 703109
SGTC_3105 9121040 49.47 µM -0.2703978585838 0.385502949276516 no 2113 0.393427093684028 653 41448907
SGTC_1991 st073000 8.92 µM -0.271141440056202 0.385220082861346 no 2114 0.393141125178734 683 4301969 YIL048W NEO1
SGTC_2568 diosmetin 100 µM -0.271789218634887 0.38497371065924 no 2115 0.392892047782484 670 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1973 st070275 50.2 µM -0.273872032954152 0.384181860727982 no 2116 0.392091482308397 652 17118334
SGTC_2504 purpurogallin 52.29 µM -0.276575803802367 0.383154654980529 no 2117 0.391052922979878 651 5281571 An antioxidant.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.277091724816648 0.382958741402139 no 2118 0.390854837892882 662 97141
SGTC_3102 9121669 49.47 µM -0.27896150697552 0.382248969739893 no 2119 0.390137182755727 649 41905072
SGTC_592 k241-0073 46.5 µM -0.279073201916088 0.382206582694505 no 2120 0.390094324103891 694 4230158
SGTC_3233 9132340 49.47 µM -0.280604496604888 0.381625615139278 no 2121 0.389506883380627 712 17682950
SGTC_2915 7971052 15.16 µM -0.280630940379738 0.381615584806356 no 2122 0.389496741138507 676 5741558
SGTC_3126 9127922 49.47 µM -0.28113719139956 0.381423575127005 no 2123 0.38930258820596 721 45595682
SGTC_1449 4112-4002 201 µM -0.28131125305432 0.381357564176589 no 2124 0.389235839994108 653 2059539
SGTC_1158 4092-0494 91.8 µM -0.282381088780728 0.380951916716728 no 2125 0.388825657085073 694 1148199
SGTC_2523 spermine 47.74 µM -0.28257365565285 0.380878915401494 no 2126 0.388751838671012 659 1103 A DNA binding polyamine.
SGTC_907 3448-6986 75.5 µM -0.283248725702857 0.380623032603457 no 2127 0.388493089655006 682 590582
SGTC_145 3737-0113 38.366 µM -0.283843551565282 0.380397609336203 no 2128 0.388265138598517 670 6849351
SGTC_2419 paclitaxel 166.5 µM -0.28447248239661 0.380159305358635 no 2129 0.388024159585471 660 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2461 5755302 26.15 µM -0.284842495946128 0.380019127243823 no 2130 0.387882406580175 718 2788904
SGTC_646 4092-0839 27.3 µM -0.286794808590929 0.379279762979134 no 2131 0.3871347190947 694 877796
SGTC_573 3702-0553 84.7 µM -0.290027331366713 0.378056539197494 no 2132 0.385897664196552 678 1222756
SGTC_1339 1486-1321 22.7 µM -0.290047159502062 0.378049039759933 no 2133 0.385890079727799 679 3469382
SGTC_539 4859-0462 2.54 µM -0.290375104318824 0.377925010473449 no 2134 0.385764643740787 658 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_875 0709-0210 25.7 µM -0.293473611508277 0.376753772495952 no 2135 0.384580083466462 710 6251364
SGTC_2074 5212007 75.395 µM -0.2954347962738 0.376013028235148 no 2136 0.38383087765821 659 758611
SGTC_2990 9074105 71.4286 µM -0.295751503552657 0.375893449874385 no 2137 0.383709930741487 690 6502001
SGTC_2773 thioridazine 9.09 µM -0.29616821974152 0.375736129561049 no 2138 0.383550808817137 670 5452 An antipsychotic.
SGTC_3291 9121177 71.43 µM -0.296476181062668 0.37561988007888 no 2139 0.3834332272555 692 17015612
SGTC_2189 6047310 154.431 µM -0.296559933154967 0.37558826722548 no 2140 0.383401252038292 664 711535
SGTC_931 2812-0076 566 µM -0.298490883477834 0.374859647613999 no 2141 0.382664266553597 665 3450959
SGTC_3207 9114163 49.47 µM -0.299578467148391 0.374449458079876 no 2142 0.382249355465451 741 849233
SGTC_2270 7924575 90.91 µM -0.300603742515679 0.374062898609066 no 2143 0.381858338637286 705 1262135
SGTC_817 1391-0715 46 µM -0.301502336730356 0.373724205809621 no 2144 0.381515734203177 697 1353946
SGTC_1487 3970-0795 2.82 µM -0.302261056183897 0.37343830967285 no 2145 0.381226531670346 676 3765103
SGTC_2836 9010338 19.48 µM -0.30252987647428 0.37333703111747 no 2146 0.381124080833203 652 2994051
SGTC_691 1548-0686 185 µM -0.304612890194973 0.372552548805774 no 2147 0.380330500686817 657 46495133
SGTC_2176 5809774 33.9695 µM -0.304955162030314 0.372423696515608 no 2148 0.380200151086701 686 2870539
SGTC_1759 st043059 70 µM -0.305071314923233 0.372379972626425 no 2149 0.380155918919279 715 669426
SGTC_2041 5107442 45.335 µM -0.30560046740274 0.372180802506906 no 2150 0.379954432277687 676 793005
SGTC_2016 5121758 140 µM -0.307239301849791 0.371564171250846 no 2151 0.379330616337207 707 2795203
SGTC_1840 st055363 71 µM -0.30772936801058 0.371379841850488 no 2152 0.379144135487061 694 676033
SGTC_351 caspofungin 25 nM -0.3087280593531 0.371004293753019 no 2153 0.378764198762828 659 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1769 st044406 64.4 µM -0.310270475156575 0.370424524836769 no 2154 0.378177640707781 698 670903
SGTC_2190 6049624 200 µM -0.310300337835311 0.370413302842384 no 2155 0.378166287135329 678 2265554
SGTC_1084 voriconazole 435 nM -0.310851593338718 0.370206168229759 no 2156 0.377956722722823 695 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2389 9091542 195.52 µM -0.313165238115993 0.36933722579263 no 2157 0.377077563497104 671 3626624 YOL127W RPL25
SGTC_2616 abietic acid 100 µM -0.313628401500056 0.369163354145634 no 2158 0.376901642933747 686 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2715 st079500 56.4 µM -0.314845887573358 0.36870643730501 no 2159 0.376439334471379 687 28246688
SGTC_142 0335-0849 62.6745 µM -0.314926980467435 0.368676010104027 no 2160 0.376408547854723 659 3889043 YPR107C YTH1
SGTC_75 0159-0059 199.013 µM -0.318102474785796 0.367485168788655 no 2161 0.375203603227498 675 5377270
SGTC_2782 7736369 71.43 µM -0.318805777810215 0.367221595114741 no 2162 0.374936898334724 687 2950836 YOL077C BRX1
SGTC_874 0599-0792 117 µM -0.31891175853902 0.367181882619922 no 2163 0.374896713757004 726 765305
SGTC_2471 5466956 24.79 µM -0.319075717841965 0.36712044752373 no 2164 0.374834548193343 683 724419
SGTC_431 k089-0097 107 µM -0.319615765174745 0.366918117351348 no 2165 0.374629810954838 714 5499420
SGTC_1401 3807-4679 7.6 µM -0.31986806047008 0.366823606910654 no 2166 0.374534175441704 668 3291456
SGTC_255 tunicamycin 200.472 nM -0.320029753981613 0.366763040366048 no 2167 0.374472887663065 708 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1866 st057638 64 µM -0.320069946713021 0.366747985639255 no 2168 0.374457653633968 687 688802
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.320307579322834 0.366658981346149 no 2169 0.374367589063074 669 6708784 An antioxidant flavonoid
SGTC_1557 sumaresinolic acid 42.3 µM -0.320642392761149 0.366533590550737 no 2170 0.374240703851685 691 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1966 st070145 16.1 µM -0.32081348721311 0.366469519560906 no 2171 0.374175868953241 678 3748532
SGTC_484 loperamide 105 µM -0.321408416730859 0.366246760934374 no 2172 0.373950452797976 659 3955 An opioid-receptor agonist.
SGTC_713 1488-1073 324 µM -0.322934337625541 0.365675618693344 no 2173 0.373372485347019 703 3312542
SGTC_2887 9044784 58.44 µM -0.323537108884854 0.365450087279892 no 2174 0.373144254278581 681 6465546
SGTC_1667 st014849 34.6 µM -0.325431258269726 0.364741680059491 no 2175 0.372427350606027 667 5348460
SGTC_586 0957-0265 8.15 µM -0.326126667691368 0.364481714347301 no 2176 0.372164260587225 697 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_195 4234-0266 16.654 µM -0.327120231809165 0.364110397265872 no 2177 0.371788475054755 691 2303354
SGTC_2867 9039098 71.43 µM -0.327366199019921 0.364018493511244 no 2178 0.371695464252381 683 6463460
SGTC_883 0850-0245 24.6 µM -0.327974750758817 0.36379114645905 no 2179 0.37146537681051 683 6823229 YPR165W RHO1
SGTC_979 1426-2828 121 µM -0.328406889727486 0.363629734040717 no 2180 0.371302017182735 702 747872
SGTC_1356 1502-0781 85.8 µM -0.328623700076638 0.363548760219693 no 2181 0.37122006603422 687 567702
SGTC_628 1636-0253 16 µM -0.332421044902085 0.36213152802658 no 2182 0.369785674839543 715 4456143
SGTC_2898 9056270 58.44 µM -0.333102729490652 0.361877311337237 no 2183 0.369528369548303 660 19154699
SGTC_2403 6032726 181.2 µM -0.333245212808797 0.361824183553258 no 2184 0.369474595878112 691 2881040
SGTC_2289 7946404 165.07 µM -0.335590419012038 0.360950109354876 no 2185 0.368589874971399 680 1246120 YPR165W RHO1
SGTC_622 1348-1566 26.3 µM -0.338735204879097 0.359779165980152 no 2186 0.367404608616095 700 7340407
SGTC_966 1300-0360 30.2 µM -0.339577096734847 0.359465914946092 no 2187 0.367087514203208 703 70588
SGTC_1829 berberine 14.4 µM -0.339671574407622 0.359430767591983 no 2188 0.36705193530691 720 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2386 9075165 157.42 µM -0.339941691135754 0.359330285985209 no 2189 0.366950219635848 697 16452277
SGTC_62 0180-0423 3.232 µM -0.341374782626126 0.358797348447569 no 2190 0.366410728343087 718 30102 YGL099W LSG1
SGTC_308 4092-1169 104 µM -0.342711548678696 0.358300480031632 no 2191 0.365907736868977 701 2268590 YDL196W YDL196W
SGTC_12 0849-0099 9.267 µM -0.343059891741476 0.358171042235305 no 2192 0.365776701934829 699 6071388
SGTC_370 0180-0345 38.7 µM -0.344229716030876 0.35773647666296 no 2193 0.36533676808364 678 3989527
SGTC_1913 st060213 96.1 µM -0.345745136049766 0.357173803537342 no 2194 0.364767130044455 717 688959
SGTC_1392 3455-1037 33.9 µM -0.346577722663966 0.356864797463803 no 2195 0.364454292248851 695 981132
SGTC_252 miconazole 1.30953 nM -0.348496263427609 0.356153108267235 no 2196 0.363733759758705 705 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_253 dyclonine 31.25 µM -0.348900416756718 0.35600325000172 no 2197 0.363582036146017 687 3180 An oral anasthetic.
SGTC_1502 4534-4282 27.7 µM -0.348933381624532 0.355991027755494 no 2198 0.363569661714763 721 3278949
SGTC_1464 k208-0027 110 µM -0.349225782143225 0.355882622117148 no 2199 0.363459905937782 701 X1464
SGTC_474 dl-dihydrosphingosine 5 µM -0.349565877387878 0.355756548619683 no 2200 0.363332261515242 687 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1881 5652484 16 µM -0.349942162420726 0.355617077930641 no 2201 0.36319105203735 724 2255129
SGTC_2301 7769476 200 µM -0.351048747659787 0.355207032287231 no 2202 0.362775888677316 698 977820
SGTC_3111 9122088 49.47 µM -0.352518335837448 0.354662734884338 no 2203 0.362224784948448 707 16876704
SGTC_268 camptothecin 39.6153 µM -0.353283913643722 0.354379302119848 no 2204 0.361937802030529 716 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1701 st028638 40.4 µM -0.353513065191521 0.354294481141403 no 2205 0.361851917838524 709 3490878
SGTC_2918 7977171 22.06 µM -0.354015613483756 0.354108487032635 no 2206 0.361663591068402 692 2236483
SGTC_703 3875-0075 71.8 µM -0.355815921850566 0.353442475293412 no 2207 0.360989212254271 719 2850814
SGTC_1770 st043884 66.3 µM -0.355979485079176 0.353381988392518 no 2208 0.360927964357337 705 670149
SGTC_2831 7999036 19.48 µM -0.358592836042714 0.352416054891263 no 2209 0.359949853427108 740 2988270
SGTC_906 1165-0455 526 µM -0.360142940183836 0.351843562203842 no 2210 0.359370121306643 732 3252859
SGTC_860 0443-0016 25.1 µM -0.361462328984245 0.351356542966836 no 2211 0.358876930558886 708 5337942
SGTC_286 k060-0067 22.9 µM -0.361650901576025 0.351286956037689 no 2212 0.358806460853437 692 5985051
SGTC_3265 9137266 49.47 µM -0.363871805226124 0.350467775340316 no 2213 0.35797686983523 679 17224265
SGTC_1058 3448-5425 97.3 µM -0.364789463430968 0.350129499632684 no 2214 0.357634285443617 723 7279705
SGTC_924 2046-0044 21.3 µM -0.367436000862414 0.349154575007159 no 2215 0.356646910960784 685 3623589
SGTC_3180 9109287 49.47 µM -0.367947906294854 0.34896611521056 no 2216 0.356456039031333 684 18891271
SGTC_1579 chlormadinone acetate 49.4 µM -0.370069089330162 0.348185591589469 no 2217 0.355665506414619 730 45114258 A steroidal progestin.
SGTC_1796 st049173 110.4 µM -0.37016335991985 0.348150918090836 no 2218 0.355630387575367 733 94134
SGTC_2865 9030313 51.95 µM -0.371414185218082 0.347690974506805 no 2219 0.355164530862067 694 42562754
SGTC_340 k038-0059 454 µM -0.371739140161099 0.347571521288469 no 2220 0.355043540197446 694 23733424
SGTC_824 1304-0008 100 µM -0.372038514349464 0.347461484931433 no 2221 0.354932086964135 692 768245
SGTC_576 1073-0113 22.7 µM -0.372042051327782 0.347460184975624 no 2222 0.354930770265907 740 5439563
SGTC_705 1124-0212 310 µM -0.373088418952292 0.347075689306464 no 2223 0.354541318882084 732 9554485
SGTC_997 3996-0078 137 µM -0.375055259451215 0.346353385130171 no 2224 0.353809685031773 706 735687
SGTC_2709 st078560 56 µM -0.37708347937354 0.345609124706088 no 2225 0.353055784049513 732 17250903
SGTC_2049 5262831 67.185 µM -0.377771830242428 0.345356668017668 no 2226 0.35280005094904 712 763417
SGTC_2140 5586273 200 µM -0.378329360101707 0.345152241108556 no 2227 0.352592968630031 697 854421
SGTC_404 fumagillin 50 µM -0.38098973603386 0.344177396314894 no 2228 0.351605432337678 714 12015870 A methionine aminopeptidase binder.
SGTC_1072 oxiconazole 14.9 nM -0.380990928778476 0.344176959487579 no 2229 0.351604989812669 700 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_918 glabranin 770.725 nM -0.382255353986809 0.343713997121606 no 2230 0.351135983505725 720 124049 Also referred to as licorice root.
SGTC_2528 xanthyletin 44.79 µM -0.382643853965416 0.343571797001709 no 2231 0.350991924824312 709 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1384 3089-0840 101 µM -0.384280743936914 0.342972900118765 no 2232 0.350385189251918 711 1069836
SGTC_303 1348-1668 34.2 µM -0.385494265247495 0.342529157600116 no 2233 0.349935627238539 718 5380509
SGTC_3330 9141424 71.43 µM -0.386215711765322 0.342265452638692 no 2234 0.349668459241919 694 27261020
SGTC_489 paxilline 115 µM -0.386466853928105 0.342173672554634 no 2235 0.34957547306605 741 105008 A toxic potassium channel blocker.
SGTC_1471 k673-0312 37 µM -0.386740561060516 0.342073656702919 no 2236 0.349474142416696 714 24099884
SGTC_177 1327-0068 8.361 µM -0.386901939279829 0.34201469236771 no 2237 0.349414402708733 687 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2843 9000894 45.46 µM -0.388241450428065 0.34152541093482 no 2238 0.348918680599749 687 2242070
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.3903030532348 0.340772892374892 no 2239 0.348156232916277 703 16486 A toxic proline analog.
SGTC_1361 1608-0041 5.61 µM -0.391251292255533 0.340426982120329 no 2240 0.347805749062999 721 X1361
SGTC_3040 9091894 49.47 µM -0.393426882308375 0.339633851278147 no 2241 0.347002108976274 698 25236966
SGTC_1364 1653-0028 37.6 µM -0.396371860707826 0.338561363825467 no 2242 0.345915360827542 721 5718652
SGTC_140 0062-0056 502.533 µM -0.397032689451931 0.338320885896588 no 2243 0.345671677431838 719 3758964
SGTC_760 0568-0725 82.9 µM -0.398035524435248 0.337956076650359 no 2244 0.34530199993339 734 3916171
SGTC_439 amiodarone 34.4 µM -0.39812676971188 0.337922891177607 no 2245 0.345268371282965 713 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_288 1315-0019 35.1 µM -0.398361411755298 0.337837558768602 no 2246 0.345181899044456 710 6811474
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.400059379221669 0.337220306543842 no 2247 0.344556391055088 713 442882
SGTC_2439 5492030 7.2 µM -0.401704588486838 0.336622650851001 no 2248 0.343950723614439 718 5722370
SGTC_3258 9138477 49.47 µM -0.402510058148106 0.336330197923391 no 2249 0.343654343787207 710 4970355
SGTC_423 5-fluorouracil 457 µM -0.402630693718923 0.336286405630955 no 2250 0.343609963108874 701 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1495 4469-0029 237 µM -0.40513913961516 0.335376310983694 no 2251 0.342687618966812 728 793680
SGTC_3257 9139206 32.98 µM -0.405243333792385 0.335338528913696 no 2252 0.342649327474286 729 4910041
SGTC_546 peri-Naphthalide 147 µM -0.405394302073725 0.335283788942036 no 2253 0.342593849307544 712 223824 A penicillin ester.
SGTC_3069 9117009 49.47 µM -0.406905065001494 0.334736190363208 no 2254 0.342038857885941 707 41904981
SGTC_1621 st003705 32.4 µM -0.407038645050859 0.334687789166237 no 2255 0.341989802531664 711 24207032
SGTC_1895 st058434 18.3 µM -0.408686338685057 0.334090992405998 no 2256 0.341384930294211 755 5393175
SGTC_3087 9117406 49.47 µM -0.409467422277389 0.333808229306328 no 2257 0.341098334834003 714 42546093
SGTC_1526 st051518 75 µM -0.409628684878353 0.333749861752271 no 2258 0.341039175714173 717 673993
SGTC_2364 9055074 200 µM -0.411509087946731 0.333069563958738 no 2259 0.340349639395363 751 6470630
SGTC_970 1315-0089 19.5 µM -0.412117850883452 0.33284944142144 no 2260 0.340126522637425 711 6811083 YLR033W RSC58
SGTC_2215 7188065 200 µM -0.413905980923901 0.332203204927485 no 2261 0.339471481775962 725 940217
SGTC_1666 st014829 29 µM -0.414848858685434 0.331862646242453 no 2262 0.339126274940626 719 3858230
SGTC_670 4204-0025 119 µM -0.417906988868859 0.330759034928282 no 2263 0.338007561249743 730 719039
SGTC_363 0455-0021 3.06 µM -0.418017538434521 0.330719167507893 no 2264 0.337967147130187 730 4597466
SGTC_1421 4029-0249 71.4 µM -0.420831274946244 0.329705098962423 no 2265 0.336939146173143 751 2894095
SGTC_2411 st077133 39.94 µM -0.421313271200104 0.329531513134076 no 2266 0.336763170305283 767 1403142 YNL221C POP1
SGTC_678 1218-2179 85.9 µM -0.422032806386106 0.329272448523347 no 2267 0.336500535944476 735 6820081 YOR116C RPO31
SGTC_1578 josamycin 24.2 µM -0.422545545087191 0.329087889824282 no 2268 0.336313432106765 750 5282165 A P450 substrate.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.423537323786886 0.328731020399749 no 2269 0.335951636509855 717 5377381
SGTC_1312 1218-2183 165 µM -0.423903047634473 0.328599462219899 no 2270 0.335818260724469 741 6744073
SGTC_174 3553-0389 74.3 µM -0.430019408920763 0.326402443833541 no 2271 0.333590761336466 709 738071
SGTC_1709 st033179 39.1045 µM -0.430931051697366 0.326075491314563 no 2272 0.333259252257212 718 573381
SGTC_1986 st071812 45 µM -0.432163510345691 0.325633693569322 no 2273 0.33281128898754 746 11838594
SGTC_349 k015-0014 24 µM -0.433226206365164 0.325252946917623 no 2274 0.332425221041099 719 2196908
SGTC_2714 st079313 56.9 µM -0.434160242596406 0.324918447520998 no 2275 0.332086040763024 723 2939799
SGTC_3299 9121982 43.1275 µM -0.43418811576211 0.32490846767989 no 2276 0.332075921181809 739 17594604 YPL160W CDC60
SGTC_161 4065-0411 162.148 µM -0.434309365004095 0.324865056485552 no 2277 0.332031902076107 743 1906281 YLR208W SEC13
SGTC_947 3447-0010 211 µM -0.434662647659507 0.324738583301308 no 2278 0.331903657283754 747 748350
SGTC_1611 st001856 99.4 µM -0.436955510630161 0.323918242964625 no 2279 0.331071806536978 764 647478
SGTC_2576 guaiol 23.12 µM -0.437155550524399 0.323846713177499 no 2280 0.330999271514427 728 227829
SGTC_2427 5545055 42.75 µM -0.440266143218026 0.322735273316817 no 2281 0.329872179561726 725 5372858
SGTC_2763 lisinopril 49.32 µM -0.44041102119026 0.32268354572472 no 2282 0.329819722012837 764 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.44082393716429 0.322536136005307 no 2283 0.32967023138525 739 94937 An inhibitor of serotonin biosynthesis.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.44120407031558 0.322400454309159 no 2284 0.329532633387292 721 5106787 A p450 inhibitor.
SGTC_1313 1220-0047 237 µM -0.442567794613105 0.321913892182867 no 2285 0.329039191791057 732 3528706
SGTC_2082 5219693 150 µM -0.445623362775627 0.320824807232115 no 2286 0.327934665810309 745 2834649
SGTC_2666 tannic acid 100 µM -0.445722293042314 0.320789571571033 no 2287 0.327898929596868 751 16134267 A thiamine antagonist.
SGTC_1302 1159-0335 255 µM -0.447064742235023 0.320311595641082 no 2288 0.327414157537025 736 649284
SGTC_250 brefeldin a 552.239 µM -0.447440976074662 0.320177691872863 no 2289 0.327278347820058 729 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3338 9144300 39.5675 µM -0.448201252650496 0.319907176587263 no 2290 0.327003979385464 737 4901274
SGTC_978 1416-0512 87.4 µM -0.448609940421176 0.319761800261214 no 2291 0.326856530859351 757 6814003
SGTC_1754 st042065 16.137 µM -0.449044641397007 0.319607201033325 no 2292 0.32669972681905 759 1126236 YIL048W NEO1
SGTC_813 k007-0158 173 µM -0.449580493393679 0.31941667108298 no 2293 0.326506478002606 746 6523916
SGTC_2337 9009472 200 µM -0.449753637998701 0.319355117194503 no 2294 0.326444045354627 755 5742383
SGTC_1648 st011736 69.8 µM -0.44982447094332 0.31932993711598 no 2295 0.326418505744589 736 2855514
SGTC_2730 imipramine 71.33 µM -0.449956836870952 0.319282885193117 no 2296 0.326370781910851 730 3696 A tricyclic antidepressant.
SGTC_25 0118-0223 35.662 µM -0.450619065328901 0.319047527527696 no 2297 0.326132061644724 749 5333628
SGTC_3210 9128157 49.47 µM -0.451217035003927 0.31883507024939 no 2298 0.325916566591814 743 17590849
SGTC_3136 9095672 49.47 µM -0.452734516547171 0.3182961797858 no 2299 0.325369960892789 715 17217380
SGTC_1378 2093-0007 380 nM -0.453217615357239 0.318124701559609 no 2300 0.325196024615555 775 3618014
SGTC_1390 3413-2614 145 µM -0.455746740235703 0.317227613469615 no 2301 0.324286053503144 768 3421432
SGTC_224 benfluorex 43.875 µM -0.456422536829133 0.316988087832038 no 2302 0.324043081314578 755 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2212 7123476 200 µM -0.460014388439767 0.315716300320738 no 2303 0.322752946396101 737 1085715
SGTC_3166 9102297 49.47 µM -0.461774341916577 0.315093937889842 no 2304 0.322121576301558 755 25237072
SGTC_2071 5230951 39.92 µM -0.462328181998252 0.314898194962359 no 2305 0.321922996358225 744 1799272
SGTC_426 0988-0037 14.6 µM -0.465002295754961 0.313953818903804 no 2306 0.320964906276518 763 5383008
SGTC_1478 0453-0656 35.7 µM -0.465054664388423 0.313935336803489 no 2307 0.320946155343032 766 5258496
SGTC_2809 7964133 12.99 µM -0.465418323966863 0.313807005815766 no 2308 0.32081595723861 770 1253665
SGTC_1070 indatraline 8.81 µM -0.465511364226987 0.313774176671062 no 2309 0.320782650324379 758 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3032 9089427 49.47 µM -0.465710159250752 0.313704037025156 no 2310 0.320711489742677 741 17173707
SGTC_1749 st037932 54.2 µM -0.465925276413558 0.313628146122722 no 2311 0.32063449391648 772 594497
SGTC_1792 st045773 43.6 µM -0.467182019488915 0.313184939090565 no 2312 0.320184828379752 719 2919270
SGTC_2384 9036245 200 µM -0.468612015386784 0.312680960237433 no 2313 0.319673493639151 746 6462766
SGTC_2316 5844804 197.44 µM -0.468865139548055 0.3125917871689 no 2314 0.319583017726017 749 776813
SGTC_1514 1189-1591 158 µM -0.469244948700491 0.312458004846681 no 2315 0.319447280067546 779 767698 YMR146C TIF34
SGTC_491 tetrandrine 80.3 µM -0.470352513358469 0.312068022255271 no 2316 0.31905159251731 758 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1622 st003707 19.4 µM -0.470978475794684 0.311847708837199 no 2317 0.318828052865029 750 10140899
SGTC_641 4092-0595 30 µM -0.472345430423224 0.311366830251291 no 2318 0.318340124036083 741 786260
SGTC_2258 7960471 200 µM -0.472364001471365 0.311360299387683 no 2319 0.318333497343692 775 2974708
SGTC_1694 st024011 44.9 µM -0.473087202111446 0.311106018265171 no 2320 0.318075483459874 771 2787533
SGTC_985 1493-0307 8.71 µM -0.473306618929943 0.311028887982354 no 2321 0.317997220298727 760 3278274
SGTC_299 1273-0059 1.44 µM -0.474652459419331 0.310555974398255 no 2322 0.317517354200699 746 2848077
SGTC_271 rotenone 740 µM -0.478069383124773 0.309356711968957 no 2323 0.316300411327776 777 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_655 k060-0012 42 µM -0.478774132197159 0.309109612931851 no 2324 0.316049660538249 744 5994525
SGTC_545 4218-0007 221 µM -0.479838397232022 0.308736624106169 no 2325 0.315671153785117 769 2840508
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.480563646445715 0.308482561793476 no 2326 0.315413328986773 749 17037758
SGTC_725 1497-0963 19 µM -0.481277240949711 0.308232671720591 no 2327 0.315159735105871 755 3549977
SGTC_2142 5622915 118.518 µM -0.481732725137733 0.308073214449125 no 2328 0.314997912786638 728 5322196
SGTC_1016 4226-1401 38 µM -0.483264804429316 0.30753712549823 no 2329 0.314453863431759 751 2901613
SGTC_2837 9008476 45.46 µM -0.483268494589725 0.307535834771877 no 2330 0.314452553522237 783 2992805
SGTC_1175 0741-0056 27.6 µM -0.484007639569878 0.307277348294478 no 2331 0.314190223681694 759 765927
SGTC_380 3970-0968 6 µM -0.484321648534655 0.307167565142599 no 2332 0.314078807196546 755 2891601
SGTC_2348 9022543 33.42 µM -0.484327242961962 0.307165609387384 no 2333 0.314076822338574 744 3162678 YDL140C RPO21
SGTC_1290 0986-0249 10.2 µM -0.484659996627967 0.307049291938291 no 2334 0.313958773679564 761 53329
SGTC_2143 5623677 140.463 µM -0.48560044799398 0.306720652550568 no 2335 0.313625239379464 732 5375313
SGTC_1417 3966-0327 90.4 µM -0.488076796903384 0.305856039367986 no 2336 0.312747722764032 749 651118
SGTC_2102 5377816 72.7585 µM -0.488184195814726 0.305818565635907 no 2337 0.312709688941852 767 1379702
SGTC_2367 9070478 135.38 µM -0.488979458790253 0.305541144992429 no 2338 0.312428119756147 741 572802
SGTC_2431 5490079 200 µM -0.490439503764405 0.305032111489669 no 2339 0.311911464296663 802 5722345
SGTC_559 1550-0661 158 µM -0.490553962356723 0.304992222301256 no 2340 0.311870977291508 744 5830875
SGTC_58 0957-0393 9 µM -0.491344018387784 0.304716948441806 no 2341 0.311591575779112 759 6997992
SGTC_2370 9071495 200 µM -0.492140912180998 0.304439404106714 no 2342 0.311309865959589 777 21791103
SGTC_1896 st058441 89 µM -0.494312193980677 0.303683755772216 no 2343 0.310542857320291 731 688759
SGTC_1564 D-Arginine 115 µM -0.494529341133864 0.303608230404246 no 2344 0.310466194966282 794 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2935 9038016 29.96 µM -0.495817050850011 0.303160527976125 no 2345 0.310011746885572 762 6463195
SGTC_1774 st048371 48.465 µM -0.496843954042681 0.302803712792063 no 2346 0.309649548389554 757 4242727
SGTC_1841 st054148 70 µM -0.496897570681657 0.302785087935236 no 2347 0.309630642364862 775 675442
SGTC_2330 7979373 200 µM -0.498073716323313 0.302376658373501 no 2348 0.309216042693884 746 1863007
SGTC_382 3229-0966 23.2 µM -0.499578709351027 0.301854393650132 no 2349 0.308685876174339 781 5722370
SGTC_616 4092-0450 108 µM -0.499595723772613 0.301848491600411 no 2350 0.308679884750501 768 787165
SGTC_952 1185-0122 232 µM -0.499813275070985 0.301773030862964 no 2351 0.308603281167644 754 678600
SGTC_2379 9035213 200 µM -0.501102521901843 0.301326011558549 no 2352 0.30814948603995 763 646551
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.503781463432686 0.300398099600672 no 2353 0.307207477528948 801 6728940
SGTC_859 0439-0102 54.6 µM -0.504588259822704 0.300118900592562 no 2354 0.306924028705242 768 610143
SGTC_1319 1306-0155 43.7 µM -0.506945117392635 0.299303962253627 no 2355 0.306096663834708 750 3122360
SGTC_615 k087-0205 167 µM -0.508088610496184 0.298908934903689 no 2356 0.305695601154356 770 9642773
SGTC_1385 3091-4834 14.1 µM -0.508775710643481 0.298671685528349 no 2357 0.305454723323833 745 4072814
SGTC_2519 cryptotanshinone 88.04 µM -0.509362675868282 0.298469079659561 no 2358 0.305249016635683 773 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1336 1486-0901 104 µM -0.511135760184604 0.297857434945797 no 2359 0.304627998616234 748 5006114
SGTC_412 gemfibrozil 100 µM -0.511303280198259 0.297799676659226 no 2360 0.304569354245158 746 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1228 0124-0032 52.5 µM -0.511469603259113 0.297742336117586 no 2361 0.304511133865096 745 X1228
SGTC_1530 rhein 70.4 µM -0.512383637770494 0.297427308994424 no 2362 0.30419127004658 755 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_808 0711-0032 135 µM -0.512554490887082 0.297368440400243 no 2363 0.304131497084774 773 4252555
SGTC_1920 st075728 45.7 µM -0.513103755609249 0.29717922360461 no 2364 0.30393937229306 774 3400306
SGTC_2354 9060492 162 µM -0.513896525888146 0.296906218407209 no 2365 0.303662168280157 773 6471895
SGTC_2595 hexamethylquercetagetin 100 µM -0.514547259528015 0.296682211965812 no 2366 0.303434713879988 789 386331
SGTC_100 0086-0128 49.5915 µM -0.515125460733509 0.296483238814747 no 2367 0.303232676014612 806 93297
SGTC_2628 lathosterol 100 µM -0.515148888713498 0.296475177964128 no 2368 0.303224490964392 759 6710616
SGTC_611 3453-1652 23.7 µM -0.515946181817909 0.296200913708684 no 2369 0.302945999005067 778 1560575
SGTC_787 4152-0075 138 µM -0.518123493258433 0.295452524632067 no 2370 0.30218605487238 741 9566539
SGTC_1856 st057054 55.7 µM -0.518143426324524 0.295445677225028 no 2371 0.302179101614628 794 1266018
SGTC_2006 4011487 200 µM -0.518786012457392 0.295224975148227 no 2372 0.301954986575331 752 45595294
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.519591443457308 0.294948449745183 no 2373 0.301674181564398 761 676296 Flavone; oxidizing agent.
SGTC_2989 9073649 71.4286 µM -0.51961823373463 0.294939253997673 no 2374 0.301664843435428 800 21367202
SGTC_1244 0416-0015 52.5 µM -0.521535690557341 0.29428143142596 no 2375 0.300996824724272 758 96201
SGTC_912 3474-0017 2.18 µM -0.522078400172457 0.294095366969254 no 2376 0.30080787243232 798 3360550
SGTC_2095 5432005 200 µM -0.522182152458315 0.294059802365547 no 2377 0.300771755649875 807 783734
SGTC_1529 apigenin 74 µM -0.524400089222514 0.293300005505238 no 2378 0.300000147242806 800 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_547 1120-0019 610 nM -0.524916041213102 0.29312338677195 no 2379 0.299820778781049 764 3676939
SGTC_1842 st055362 61.2 µM -0.525202309462122 0.293025413788018 no 2380 0.299721279820199 730 676032
SGTC_577 r071-0003 38.6 µM -0.526182698657516 0.292689998703791 no 2381 0.299380636903205 775 4568517 YMR134W ERG29
SGTC_933 2914-0560 114 µM -0.52708920241602 0.292380020397248 no 2382 0.299065822299399 750 463887
SGTC_3321 9137793 26.8275 µM -0.529451183764663 0.291573060452098 no 2383 0.298246249931999 749 4904192
SGTC_198 3454-2873 16.191 µM -0.529707348220854 0.291485605514608 no 2384 0.298157426187207 778 710957
SGTC_337 1315-0038 354 µM -0.529835784386265 0.291441761816614 no 2385 0.298112896124668 777 1626437
SGTC_3270 9137563 49.47 µM -0.530176951220133 0.291325314112919 no 2386 0.297994624995349 756 17015724
SGTC_1329 1447-1697 50.6 µM -0.531024841419226 0.29103600471922 no 2387 0.297700782487889 761 2840515
SGTC_2566 crystal violet carbinol 226 nM -0.531947095091508 0.290721474171058 no 2388 0.297381318966744 794 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3255 9139072 49.47 µM -0.532873121493747 0.290405816987046 no 2389 0.297060706243259 764 17646060
SGTC_1791 st048313 56.1 µM -0.534432037420819 0.289874787730946 no 2390 0.296521329228751 762 1204976
SGTC_892 0929-0076 29 µM -0.534756563269514 0.289764298518189 no 2391 0.296409101385385 746 5751038
SGTC_1794 st048918 76.9 µM -0.537866405840533 0.288706513891888 no 2392 0.295334641309773 762 672303
SGTC_2648 atorvastatin 78.68 µM -0.53887835164847 0.288362702291431 no 2393 0.294985397830837 791 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1729 st035615 45.989 µM -0.54038638878695 0.287850700663966 no 2394 0.294465296308365 775 17385451
SGTC_2545 solidagenone 89.61 µM -0.54118125104693 0.287581005699219 no 2395 0.294191329566221 730 6708572 An anti ulcer agent
SGTC_1620 st003704 16.5 µM -0.541434635405399 0.287495058075413 no 2396 0.294104019840748 775 2834414
SGTC_3190 9110366 49.47 µM -0.542456747692469 0.287148482379369 no 2397 0.293751947909655 765 17123768
SGTC_2327 6189656 200 µM -0.542802425621887 0.287031315405078 no 2398 0.293632921484231 796 5349088
SGTC_1726 st035556 14.5795 µM -0.542924092941878 0.286990081851888 no 2399 0.293591033389891 766 5919439
SGTC_3298 9116858 71.43 µM -0.543107766423432 0.286927839472088 no 2400 0.293527802816504 809 2506942
SGTC_1734 st037168 69.4 µM -0.543839036453693 0.286680093667481 no 2401 0.293276121776377 783 708907
SGTC_158 k038-0087 26.446 µM -0.545076816477599 0.286260979452252 no 2402 0.292850343405034 740 X158
SGTC_722 3534-0461 190 µM -0.545414737042125 0.286146609609232 no 2403 0.292734153514905 762 658262
SGTC_121 0557-0495 61.343 µM -0.546942961922035 0.285629650296844 no 2404 0.292208959439186 793 3104427
SGTC_1126 isoteolin 1.0172 µM -0.547130644313593 0.285566192807886 no 2405 0.29214449021527 746 133323
SGTC_313 3474-0040 5.03 µM -0.54764038925905 0.285393876282912 no 2406 0.291969425361036 774 1043375 YIL048W NEO1
SGTC_2608 thymoquinone 42.66 µM -0.549037154534255 0.284921961238975 no 2407 0.291489976120247 784 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2643 anethole 100 µM -0.549327874025766 0.284823784751881 no 2408 0.291390230853557 806 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2849 9019321 12.99 µM -0.549723608866658 0.284690170341392 no 2409 0.291254480632767 751 16489627
SGTC_2294 7971431 200 µM -0.550604051326455 0.284393008472184 no 2410 0.290952565518091 808 5741572
SGTC_729 4092-0585 94.1 µM -0.551137056306381 0.284213183752174 no 2411 0.290769862306387 767 2169061
SGTC_3095 9117207 49.47 µM -0.552719168460595 0.283679732654752 no 2412 0.2902278627877 774 17015229
SGTC_1159 4092-0538 61.2 µM -0.552736150122342 0.283674009439166 no 2413 0.290222047783111 777 717301
SGTC_1253 0550-0034 176 µM -0.553363383687794 0.283462655873003 no 2414 0.290007303397426 758 5969915
SGTC_2588 indole-3-carbinol 100 µM -0.55475853901445 0.282992813076108 no 2415 0.2895299148761 789 3712 Induces cell cycle arrest.
SGTC_1116 jasmonic acid 1.58368 µM -0.554942247026165 0.282930974077154 no 2416 0.289467081927771 802 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1394 3474-0001 65.7 µM -0.556026754587298 0.282566044091042 no 2417 0.289096282526189 754 5017666 YIL048W NEO1
SGTC_2290 7904846 200 µM -0.556450320772506 0.282423578200582 no 2418 0.288951523482919 762 2962154
SGTC_1165 k072-0275 30.3 µM -0.556676629717266 0.282347473668394 no 2419 0.288874193551457 770 6153523 YGL055W OLE1
SGTC_2492 derrusnin 100 µM -0.559888363732126 0.281268477372427 no 2420 0.287777793118084 800 1715307 Part of coumarin class of compounds.
SGTC_973 1325-0077 65.9 µM -0.560694138905893 0.280998086337807 no 2421 0.287503031722685 780 2835149
SGTC_1042 0350-0096 82 µM -0.561273452972263 0.280803765677594 no 2422 0.287305568015368 765 3122515
SGTC_836 0330-0104 1.35 µM -0.562290261694438 0.280462852364076 no 2423 0.28695913609975 757 46494820
SGTC_1508 1080-0625 72.9 µM -0.562458150593787 0.280406582233481 no 2424 0.286901954535715 788 767111
SGTC_3071 9117417 49.47 µM -0.563306211135971 0.280122427371713 no 2425 0.28661319470735 777 45595590 YGL055W OLE1
SGTC_2922 7999257 32.47 µM -0.564075027403925 0.279864945096168 no 2426 0.286351536287927 795 2988377
SGTC_3313 9133968 57.047 µM -0.56449834638466 0.279723221446532 no 2427 0.286207512610068 783 1494643
SGTC_3097 9117246 49.47 µM -0.565765312095386 0.279299260146698 no 2428 0.28577666496079 776 16423892
SGTC_1852 st056254 31.4 µM -0.566692263037787 0.278989274981412 no 2429 0.285461639152709 785 442583
SGTC_2136 5328288 199.296 µM -0.56691408864589 0.278915118264236 no 2430 0.285386275879064 778 262395
SGTC_1209 2323-2347 50.3 µM -0.567214078477504 0.278814846356733 no 2431 0.285284372081583 779 5412760
SGTC_2965 9082772 38.63 µM -0.567481082985283 0.278725614586189 no 2432 0.285193687679707 745 16459634
SGTC_2861 9024595 19.48 µM -0.567676969314952 0.278660159050373 no 2433 0.285127166324265 755 16482810
SGTC_2821 7996764 71.43 µM -0.569025733135527 0.278209672100331 no 2434 0.284669338332504 742 2987135
SGTC_501 nsc-95397 161 µM -0.569116374932991 0.278179410490329 no 2435 0.284638583227968 791 262093
SGTC_2812 7970281 58.44 µM -0.571269494345375 0.277461043815221 no 2436 0.283908488489711 793 2233435
SGTC_618 k072-0232 33.2 µM -0.571771152924535 0.277293800807336 no 2437 0.283738511429726 793 5872756 YGL099W LSG1
SGTC_2476 5806916 10.51 µM -0.574197900963386 0.276485467999897 no 2438 0.282916944791137 775 2870194
SGTC_410 α-linolenic acid 100 µM -0.574382256357814 0.276424107758889 no 2439 0.282854578663308 787 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_741 4582-0002 126 µM -0.577847015363937 0.275272152624246 no 2440 0.281683705018513 791 2912688
SGTC_373 0844-0104 25.9 µM -0.578925607432395 0.274914027716756 no 2441 0.281319685349745 788 5375804
SGTC_1712 st032288 53.4 µM -0.580352222575113 0.274440701662132 no 2442 0.280838558643034 781 2883011
SGTC_1320 1313-0481 95.3 µM -0.58041412002178 0.274420174274656 no 2443 0.280817692704727 791 6813365 YLR208W SEC13
SGTC_1556 plumbagin 1.48 µM -0.581860990864075 0.273940556618182 no 2444 0.280330158991419 784 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1937 st074714 47.2 µM -0.582390002591489 0.273765300055141 no 2445 0.280152007010256 778 17250970
SGTC_820 1582-0060 59.9 µM -0.582655791966349 0.273677267493006 no 2446 0.280062519490345 787 3848840
SGTC_593 1203-0218 61.7 µM -0.583090383614013 0.273533355812369 no 2447 0.279916228489782 801 3666956
SGTC_2556 citropten 84.59 µM -0.583222165448834 0.27348972467344 no 2448 0.279871875787629 760 2775 A potential DNA crosslinker.
SGTC_2502 avocadyne acetate 18.59 µM -0.583384830379194 0.273435873320714 no 2449 0.279817133722785 766 3952079
SGTC_397 arbidol 50 µM -0.584353072742673 0.273115438641048 no 2450 0.279491396042358 787 131410 A RNA synthesis inhibitor.
SGTC_1710 st031758 61.5 µM -0.585082957411663 0.272874010258291 no 2451 0.279245968832049 795 5394341
SGTC_1465 k213-0056 144 µM -0.585142968241877 0.272854164821806 no 2452 0.279225794564138 795 24048857 YMR208W ERG12
SGTC_702 1488-0190 94 µM -0.585483470854898 0.272741574987113 no 2453 0.27911133879178 780 949357
SGTC_2464 5717415 7.67 µM -0.585608930206867 0.272700096689725 no 2454 0.27906917292257 777 5285744
SGTC_176 1486-1328 72.834 µM -0.585917583815098 0.272598065600167 no 2455 0.278965450138063 784 22310231
SGTC_1957 st077035 62.4 µM -0.586520129477728 0.272398937743503 no 2456 0.278763019229912 802 705593
SGTC_1597 7-benzyloxygramine 47.5 µM -0.588526311950219 0.271736460524019 no 2457 0.278089539083433 805 260807
SGTC_2153 5569715 200 µM -0.58879023399317 0.271649368484193 no 2458 0.278000998948488 783 2054701
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.589888212356192 0.271287194154861 no 2459 0.277632798682909 793 616764
SGTC_2456 5770359 74.46 µM -0.590319531888831 0.271144986855111 no 2460 0.277488223544376 820 3118787
SGTC_47 0149-0135 24.25 µM -0.591431818382544 0.270778434386012 no 2461 0.27711556316964 777 5239155
SGTC_1762 st045503 25.4615 µM -0.59201973919484 0.27058478588249 no 2462 0.276918685213524 795 4645554
SGTC_2775 cyproheptadine 69.59 µM -0.592574734497145 0.270402045831477 no 2463 0.276732895938875 804 2913 A selective serotonin reuptake inhibitor.
SGTC_2347 9049783 174.81 µM -0.594331095611336 0.269824145870113 no 2464 0.276145342265204 830 6467988 YPL169C MEX67
SGTC_2835 9006588 71.43 µM -0.59500951957565 0.269601087988849 no 2465 0.275918553853529 764 2345538
SGTC_1242 0402-0103 60.1 µM -0.595284618901739 0.269510664875803 no 2466 0.275826617763139 801 432868
SGTC_2138 5575593 77.673 µM -0.595319976565202 0.26949904417582 no 2467 0.27581480259418 807 762213
SGTC_3355 9151058 44.0485 µM -0.595704509775177 0.269372679162791 no 2468 0.275686322471635 798 17015728
SGTC_2585 alliin 100 µM -0.596573530039832 0.269087211853991 no 2469 0.275396074095606 813 87310 A garlic compound which reacts with lipids.
SGTC_3162 9099653 49.47 µM -0.597083482895994 0.268919766482619 no 2470 0.275225822450256 774 25237511
SGTC_2362 9071156 126 µM -0.598263016724495 0.268532661666394 no 2471 0.274832224738484 802 653133
SGTC_582 0987-0078 156 µM -0.600853651168044 0.267683439741321 no 2472 0.273968733048955 811 1625765
SGTC_138 0850-0259 40.9225 µM -0.605675804105152 0.266106328520698 no 2473 0.272365027081631 792 6813004
SGTC_2035 5154463 94.595 µM -0.606993139633987 0.265676306562582 no 2474 0.271927732480684 816 2769623
SGTC_2685 mycophenolic acid 18.85 µM -0.608402064933973 0.265216776946864 no 2475 0.271460421138628 790 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_99 0109-0120 622.8 µM -0.608475679353001 0.265192778252117 no 2476 0.271436015762202 806 759414
SGTC_184 1494-0393 24.714 µM -0.608526048508541 0.265176358273133 no 2477 0.271419317514089 812 3090647
SGTC_1066 ketoconazole 628 nM -0.609993647178258 0.264698158547962 no 2478 0.270933007934904 814 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_805 3852-0218 479 µM -0.611402156070817 0.264239625306799 no 2479 0.270466687814364 792 6615355
SGTC_1989 st071868 50.2 µM -0.611983294631662 0.264050556412034 no 2480 0.27027440511568 804 16414057
SGTC_2603 homopterocarpin 100 µM -0.613464192959301 0.263569069536816 no 2481 0.269784725967315 807 101795 A weak amylase inhibitor.
SGTC_2109 5483026 200 µM -0.613520168104899 0.263550879037757 no 2482 0.26976622574216 835 759335
SGTC_930 2810-3379 265 µM -0.614387519113906 0.263269093911926 no 2483 0.269479640639138 828 1015764
SGTC_2116 5511452 16.8835 µM -0.61489468021604 0.263104398657521 no 2484 0.269312138130477 815 870744
SGTC_2146 5545642 200 µM -0.616050848693975 0.26272914196553 no 2485 0.268930480156645 795 825326
SGTC_2250 alverine citrate 130 µM -0.616127261587376 0.262704350341924 no 2486 0.268905265383758 799 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2326 6164455 177.58 µM -0.616761155925808 0.262498733955348 no 2487 0.268696138324331 797 2888790
SGTC_3167 9103034 49.47 µM -0.61697101316333 0.262430680692543 no 2488 0.268626922669651 800 5127859
SGTC_270 tamoxifen 5.46 µM -0.618170480041236 0.262041886683095 no 2489 0.26823148345427 816 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.618400486074074 0.26196736650589 no 2490 0.268155688741756 833 65057 A dermal irritant. YDR527W RBA50
SGTC_2010 4012422 159 µM -0.619491847821064 0.261613921884676 no 2491 0.267796195361931 803 952393
SGTC_1166 k206-0078 225 µM -0.621555423495112 0.260946288980207 no 2492 0.267117120015838 795 5404595
SGTC_1260 0700-1617 7.75 µM -0.622398721473316 0.260673707450586 no 2493 0.266839860463816 791 2853078
SGTC_1660 st012960 28.1 µM -0.625410049797364 0.259701544846842 no 2494 0.265850983955235 817 24207266
SGTC_1150 3909-7983 10.9 µM -0.625824751727393 0.259567811237916 no 2495 0.265714947498009 808 23965914
SGTC_3029 9088683 49.47 µM -0.625885587962895 0.259548195682071 no 2496 0.265694994094914 788 25236615
SGTC_976 1348-1067 47.6 µM -0.626942297319704 0.25920760081071 no 2497 0.265348529995901 814 5310671 YGL099W LSG1
SGTC_1604 st002052 72.4 µM -0.628049276658589 0.25885105102056 no 2498 0.264985829931819 780 6254834 YHR062C RPP1
SGTC_2295 7971645 200 µM -0.631509419523882 0.257738203332053 no 2499 0.263853746102827 802 2978226 YKL099C UTP11
SGTC_511 blebbistatin 171 µM -0.632226638908856 0.257507843086942 no 2500 0.263619396361449 809 3476986 A myosin inhibitor.
SGTC_563 tetrahydrosecaminediol 614 µM -0.635080493630469 0.256592287748618 no 2501 0.262687959192782 821 334274 A psychoactive constituent of the cannabis plant.
SGTC_1678 st019265 80.2 µM -0.637085371769184 0.255950110963725 no 2502 0.262034618206203 809 5367020
SGTC_2329 6138490 200 µM -0.639859835747274 0.255062815519921 no 2503 0.261131863845685 816 720019
SGTC_2957 9076800 11.52 µM -0.640736522362764 0.2547827791495 no 2504 0.260846940506034 822 16459615
SGTC_2866 9034245 58.44 µM -0.641375847297768 0.254578663772343 no 2505 0.260639260643558 800 6462273
SGTC_1638 st008370 60.6 µM -0.642705652491361 0.254154375351251 no 2506 0.260207556284157 799 24207134
SGTC_1174 0739-0097 51.1 µM -0.642911296099841 0.254088795707117 no 2507 0.260140829614827 806 728447
SGTC_7 0192-1582 4.227 µM -0.644480021043677 0.253588822374893 no 2508 0.259632104517403 842 252616
SGTC_2069 5228469 200 µM -0.645409340955516 0.25329287980347 no 2509 0.259330975842116 833 2835210
SGTC_2336 9001819 198.65 µM -0.645958481488515 0.253118091005218 no 2510 0.259153122019513 821 2989602
SGTC_136 0097-0015 404.482 µM -0.646727858355799 0.252873308793383 no 2511 0.258904044883984 812 4861337
SGTC_3039 9090270 49.47 µM -0.647725338057303 0.252556139781964 no 2512 0.258581306477778 796 17173750
SGTC_811 0416-0114 265 µM -0.649215059875428 0.252082842880263 no 2513 0.25809968942787 811 6612453
SGTC_428 3448-4153 16.5 µM -0.649835813206136 0.251885762630118 no 2514 0.257899141431569 792 3834874
SGTC_248 streptozotocin 5.23457 mM -0.650090521992854 0.251804919793637 no 2515 0.25781687556437 836 5300 DNA alkylating agent.
SGTC_2514 salinomycin 42.74 µM -0.650139920949435 0.251789242486968 no 2516 0.257800922261755 823 23682228 A polyether potassium ionophore.
SGTC_3112 9123419 49.47 µM -0.6506696838934 0.251621148744796 no 2517 0.257629868502707 838 17015854
SGTC_1098 clofazimine 15.1 µM -0.650697025240045 0.251612474946468 no 2518 0.25762104192699 827 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1314 1222-0010 41.1 µM -0.651601725262665 0.251325556036251 no 2519 0.257329067238651 829 3526027
SGTC_2797 7859098 81.82 µM -0.65189973149767 0.251231083452271 no 2520 0.257232929074393 811 972681
SGTC_20 0481-0013 4.944 µM -0.652059214182193 0.251180532690711 no 2521 0.257181486907432 818 182045
SGTC_969 1313-0238 134 µM -0.652531669997832 0.251030811327271 no 2522 0.257029124640505 830 5212874
SGTC_1873 rapamycin 2 nM -0.655786982170019 0.250000486982506 no 2523 0.255980596742293 800 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2179 6298986 200 µM -0.655999752970922 0.249933222058604 no 2524 0.255912141581418 809 738374
SGTC_2245 6637752 200 µM -0.656570734335546 0.249752760667681 no 2525 0.255728485869995 817 681890
SGTC_3273 9137859 49.47 µM -0.658539171835992 0.2491311573788 no 2526 0.255095867419212 856 2377234
SGTC_1074 carmofur 3.8 µM -0.659076631611325 0.248961578706799 no 2527 0.2549232804196 827 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1061 3448-9325 110 µM -0.659422530680186 0.248852473539096 no 2528 0.254812238977614 828 723482
SGTC_1221 2958-7315 257 µM -0.662260234011641 0.247958353108209 no 2529 0.253902228667381 820 4562705
SGTC_843 0310-0051 143 µM -0.662555140861122 0.247865530545213 no 2530 0.253807754254509 830 2065037
SGTC_732 3970-1727 52.7 µM -0.663939293352142 0.247430113519437 no 2531 0.253364582989499 826 1275699
SGTC_964 1287-0107 19.4 µM -0.665427694589066 0.246962359148389 no 2532 0.252888488106115 806 51516812 YPR165W RHO1
SGTC_2436 5633522 8.09 µM -0.665470022498738 0.24694906383536 no 2533 0.252874955567588 831 5724242
SGTC_900 1112-0045 141 µM -0.666934827792601 0.246489200529754 no 2534 0.252406881667865 814 56211 YIL048W NEO1
SGTC_1358 1509-0022 2.48 µM -0.670267390821068 0.245444682111579 no 2535 0.25134367534503 834 3258434
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.671075139753115 0.245191869591482 no 2536 0.251086331589483 828 688761
SGTC_3199 9111318 49.47 µM -0.671903157313163 0.244932858719478 no 2537 0.250822675127663 801 8548020
SGTC_1891 st059073 26.2 µM -0.672235435047673 0.244828960853262 no 2538 0.25071691283395 826 688754
SGTC_103 0844-0104 51.839 µM -0.672436557323701 0.244766084701253 no 2539 0.250652908123494 827 5375804
SGTC_1381 2324-0066 62.1 µM -0.675061901497735 0.243946130470347 no 2540 0.249818218808086 831 10885928
SGTC_3019 9081971 49.47 µM -0.675722823881597 0.243739943247704 no 2541 0.249608321071018 832 16451803
SGTC_1068 loratadine 26.9 µM -0.675763807278708 0.24372716080127 no 2542 0.249595308524762 840 3957 A H1 histamine antagonist.
SGTC_2064 5220758 200 µM -0.67615419254654 0.243605420400441 no 2543 0.249471376243657 817 788518
SGTC_1309 pyrazolanthrone 13.4 µM -0.676172535868555 0.243599700901837 no 2544 0.249465553750168 840 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_101 0490-5701 117.494 µM -0.677775266920949 0.243100245017057 no 2545 0.24895709762033 816 4661669
SGTC_1271 0832-2808 169 µM -0.678354380816213 0.242919913198318 no 2546 0.248773513189518 840 3663794
SGTC_740 k014-0057 261 µM -0.68041360669515 0.242279271995402 no 2547 0.248121303923611 832 4012779
SGTC_2400 5203494 178.7 µM -0.680570673741553 0.242230444827397 no 2548 0.248071594255124 840 6777674
SGTC_1821 st053465 65.6 µM -0.681453192045502 0.241956197055145 no 2549 0.247792387559341 815 675086
SGTC_2233 sulbentine 40.3845 µM -0.682748031067592 0.241554123216045 no 2550 0.247383036769043 822 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1119 parthenolide 318.541 nM -0.683417431022049 0.241346403277798 no 2551 0.247171554286785 850 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2760 etidronate 98.04 µM -0.683937438760531 0.241185107892674 no 2552 0.247007335806768 834 3305 A chelator and antioxidant.
SGTC_2260 7964312 200 µM -0.684164226665361 0.241114781442342 no 2553 0.246935734456266 827 231951
SGTC_1060 3448-7350 82 µM -0.684311468452036 0.241069128044668 no 2554 0.246889253309096 831 570178
SGTC_2571 chrysanthemic acid 100 µM -0.684636715419887 0.240968299492725 no 2555 0.246786596254279 856 2743 An insecticide.
SGTC_1254 0550-0035 264 µM -0.685693234265592 0.240640930500542 no 2556 0.246453287051674 833 15121435
SGTC_578 3460-0051 92 µM -0.686632257048237 0.240350171730736 no 2557 0.24615724795405 853 2876744
SGTC_3106 9121286 49.47 µM -0.6874545166915 0.240095724719774 no 2558 0.245898176642726 812 15943471
SGTC_2278 7948257 134.34 µM -0.688313503627788 0.239830069409849 no 2559 0.245627689934657 827 1247028
SGTC_1434 4073-0095 163 µM -0.688351972973424 0.239818175908204 no 2560 0.245615580048044 833 24133745
SGTC_1420 4'-methoxyflavone 42 µM -0.689206558532464 0.239554048143152 no 2561 0.245346645068814 822 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_403 arphamenine a 50 µM -0.689446921398345 0.239479787534727 no 2562 0.245271032274109 834 5487158 An arginine aminopeptidase inhibitor.
SGTC_3146 9095609 49.47 µM -0.690695085045708 0.23909436696391 no 2563 0.244878589351683 831 17173999
SGTC_273 hydroxyurea 18.1 mM -0.690781729882199 0.23906762448741 no 2564 0.244851359356853 856 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2937 9044753 11.33 µM -0.691996898110618 0.238692741475671 no 2565 0.244469638481502 821 6465530 YGL099W LSG1
SGTC_1433 4060-0023 7.6 µM -0.692603012556025 0.238505873668649 no 2566 0.244279359624087 830 3840627
SGTC_1967 st070177 51.4 µM -0.692927465967806 0.23840587614356 no 2567 0.244177536056835 846 5729214
SGTC_67 0335-0847 266 µM -0.694445120737185 0.237938435334379 no 2568 0.24370155284343 852 4552207 YOR254C SEC63
SGTC_3323 9138564 53.9225 µM -0.695287970944826 0.237679052907733 no 2569 0.243437425606317 831 43912313 YNL103W MET4
SGTC_3164 9100705 49.47 µM -0.69694386742704 0.23716991213334 no 2570 0.24291896163251 808 17174235
SGTC_2397 5161689 200 µM -0.697199180001693 0.237091464171918 no 2571 0.242839076026357 841 2259942
SGTC_1677 st019204 53.9 µM -0.698324407611122 0.236745893956752 no 2572 0.242487169252704 827 3945625
SGTC_1226 3909-7979 35.4 µM -0.698490134937836 0.236695020621974 no 2573 0.242435362581144 837 6615510
SGTC_2148 5546263 113.568 µM -0.700083891794323 0.236206092010592 no 2574 0.241937457449491 832 792097
SGTC_804 1595-0054 20.9 µM -0.701231415723052 0.235854402303836 no 2575 0.241579303593428 840 761523 Stimulates phospholipase C.
SGTC_1731 st035964 63 µM -0.701887554432803 0.235653440658409 no 2576 0.241374645486348 861 6739575
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.704303255998509 0.23491437606067 no 2577 0.240621969531204 851 688801
SGTC_2105 5350118 200 µM -0.706099843146678 0.234365556179159 no 2578 0.240063024629887 844 2133313
SGTC_1400 3771-8998 51.5 µM -0.706102279246899 0.23436481248342 no 2579 0.240062267203857 819 670767
SGTC_1753 st043925 64 µM -0.707107222236457 0.234058133640625 no 2580 0.239749924060808 843 670181
SGTC_2994 9053520 71.4286 µM -0.70736630438419 0.233979105492857 no 2581 0.239669435527586 833 4647384
SGTC_1889 st059080 5.18 µM -0.707414246886831 0.233964483152904 no 2582 0.239654542943198 827 176925 Isolated from Daphnopsis sellowiana.
SGTC_274 sirtinol 40.1 µM -0.707722236492955 0.233870559188613 no 2583 0.239558882861476 819 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3175 9106517 49.47 µM -0.707824713828529 0.233839312515064 no 2584 0.23952705851917 848 41468073
SGTC_2738 aclarubicin 5.55 µM -0.709260945553077 0.233401630275405 no 2585 0.239081279633117 800 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_468 gf-109203x 121 µM -0.710098375775327 0.233146638791578 no 2586 0.238821566734341 819 2396 A protein kinase C inhibitor.
SGTC_1007 4101-0031 70 µM -0.710237266873615 0.233104362407465 no 2587 0.238778507252446 860 1146276
SGTC_490 phenamil 164 µM -0.712572801065233 0.232394098434943 no 2588 0.238055073690512 828 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2003 4023581 200 µM -0.713156478319014 0.23221678337248 no 2589 0.237874467007466 851 16641307
SGTC_727 3032-0951 202 µM -0.716592085563971 0.231174608942022 no 2590 0.236812914678081 840 3652836
SGTC_651 3253-0966 34.4 µM -0.717198486789166 0.230990931483823 no 2591 0.236625816426492 848 781462
SGTC_317 4495-0002 170 µM -0.71735093587614 0.23094476784393 no 2592 0.236578792777511 830 15991618
SGTC_2448 5185112 27.17 µM -0.717694297063872 0.230840812312232 no 2593 0.23647290021378 827 5718189
SGTC_2839 9003951 25.97 µM -0.719206724045442 0.230383223321388 no 2594 0.236006778511036 822 2990634
SGTC_2159 5658611 73.75 µM -0.722942192037469 0.229255223068869 no 2595 0.234857700248131 853 793844
SGTC_926 2268-1401 59.4 µM -0.723368390660819 0.229126720867073 no 2596 0.234726792853097 850 2931578
SGTC_2856 9022925 19.48 µM -0.723462058351673 0.229098484745353 no 2597 0.234698028122975 830 4944862
SGTC_2526 patulin 37.61 µM -0.724067500407097 0.228916021350225 no 2598 0.234512147883429 844 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_639 0833-0042 114 µM -0.725519578616462 0.228478737888882 no 2599 0.234066669089679 865 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_275 trichlorophene 5.69 µM -0.726784860815373 0.228098089693808 no 2600 0.233678879316691 838 62616
SGTC_1670 st016595 4.04 µM -0.726802117532989 0.228092900639614 no 2601 0.233673592858072 863 597879
SGTC_2701 st077767 14.721 µM -0.727505023743067 0.227881594833662 no 2602 0.233458319475223 835 5721188
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.728450359593082 0.227597584222756 no 2603 0.233168972680426 871 6708760
SGTC_1723 st034307 2.5525 µM -0.728925094681466 0.227455033080448 no 2604 0.233023741691737 855 867466
SGTC_1252 0493-0875 34.8 µM -0.72912811538806 0.22739408636581 no 2605 0.23296164892234 831 3960963
SGTC_2995 9067767 71.4286 µM -0.732234378317759 0.226462735772827 no 2606 0.23201276223485 837 11673567
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.732277207391085 0.226449909406839 no 2607 0.231999694066857 842 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2067 5224629 34.075 µM -0.73298564078997 0.226237808696625 no 2608 0.231783593668468 845 2835000
SGTC_2019 4016004 108 µM -0.733659641493705 0.22603612115943 no 2609 0.231578100751698 853 45595336
SGTC_3250 9135583 49.47 µM -0.735614972788333 0.225451584565394 no 2610 0.230982523965133 842 7699353
SGTC_2145 5634607 200 µM -0.73579298386373 0.225398411568468 no 2611 0.230928345849083 856 308662
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.736329460711838 0.225238205603298 no 2612 0.230765110697752 872 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2533 agelasine 13.65 µM -0.736431583915484 0.225207716262522 no 2613 0.230734044718894 825 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_753 1322-0200 289 µM -0.736806700292019 0.225095743651427 no 2614 0.230619954001436 833 5403907
SGTC_1144 3486-0183 12.5 µM -0.737299069340676 0.224948818886759 no 2615 0.230470249027204 879 6744069
SGTC_327 1273-0057 3.96 µM -0.73773072189136 0.224820056879529 no 2616 0.23033904962286 841 3108138
SGTC_39 0986-0283 58.349 µM -0.738033444374566 0.224729779662424 no 2617 0.230247063017774 818 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1859 st055998 20 µM -0.739747071362573 0.224219133420918 no 2618 0.229726740183786 856 676301
SGTC_1545 lovastatin 49.4 µM -0.740040270699769 0.224131828573474 no 2619 0.229637779648078 835 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.741193093417528 0.223788744210245 no 2620 0.229288185236661 845 6708514
SGTC_2941 9056145 11.23 µM -0.741589092909704 0.223670962196537 no 2621 0.229168166962458 843 2119517
SGTC_1211 1056-0033 32.3 µM -0.742874013687155 0.223289031411963 no 2622 0.228778979965462 841 6741922
SGTC_2953 9074162 66.49 µM -0.744960581843664 0.222669609841176 no 2623 0.228147774847506 820 16451992
SGTC_1118 chelidonine 707.474 nM -0.747331084861755 0.221967088893327 no 2624 0.227431866597554 851 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_223 busulfan 5 mM -0.748028045699204 0.221760778972596 no 2625 0.22722162058917 842 2478 A DNA alkylator.
SGTC_681 1642-0006 26.6 µM -0.748478193616969 0.22162758729118 no 2626 0.227085886691746 877 4446530
SGTC_1679 SEC14.276 6.7 µM -0.74944703577459 0.221341077284198 no 2627 0.22679390512955 845 1005053 YMR079W SEC14
SGTC_350 k064-0020 19.8 µM -0.74975669820961 0.221249547317739 no 2628 0.226700626337721 845 2790705
SGTC_844 0330-0132 15.3 µM -0.749824208626136 0.221229595475939 no 2629 0.226680293229394 850 2828079
SGTC_731 3966-0296 387 µM -0.749885775183893 0.221211401163021 no 2630 0.226661751218034 836 660956
SGTC_51 1013-0126 23.419 µM -0.752444441403612 0.220456014677216 no 2631 0.22589191465867 840 1627850
SGTC_425 3825-7017 13.1 µM -0.752810118019909 0.220348178056366 no 2632 0.225782012892267 840 3397440
SGTC_2581 avocatin a 64 µM -0.753092321892971 0.2202649779015 no 2633 0.22569721900472 860 6710728 A skin care supplement.
SGTC_803 4488-1585 147 µM -0.753211500416973 0.22022984675788 no 2634 0.22566141480717 841 747204
SGTC_2911 7942208 15.64 µM -0.754526538129958 0.219842416653847 no 2635 0.225266558148397 823 1243384
SGTC_2663 amphotericin b 100 µM -0.755345555961967 0.219601319371778 no 2636 0.225020835588612 846 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2231 micatex 6.853 µM -0.75579811159964 0.219468164070261 no 2637 0.22488512456796 859 20737 An antifungal of unknown mechanism.
SGTC_1531 st059297 52.4 µM -0.755935394131889 0.219427780645611 no 2638 0.224843965870122 864 7566702
SGTC_1317 1273-0028 910 nM -0.757609321049482 0.218935717007653 no 2639 0.224342449219222 860 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1350 1495-0454 146 µM -0.757620843715409 0.218932332032909 no 2640 0.224338999174458 845 1069057
SGTC_527 4476-4215 268 µM -0.760023782380831 0.218227086869887 no 2641 0.223620184604462 837 4418754
SGTC_2324 6149169 200 µM -0.761955183373657 0.217661184774731 no 2642 0.223043376390507 851 2888231
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.763681885558535 0.217155977256769 no 2643 0.222528419096299 851 15053
SGTC_420 mitomycin C 81.9 mM -0.763923435414585 0.217085357393895 no 2644 0.222456435367199 842 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2018 5133068 143 µM -0.764481973069936 0.216922113349808 no 2645 0.222290037682648 869 785362
SGTC_842 0271-0008 11.1 µM -0.76706891272822 0.216166953385873 no 2646 0.221520271974102 841 1221709
SGTC_1699 st031318 29.054 µM -0.767534290310689 0.216031265610424 no 2647 0.221381956838832 852 5340658
SGTC_889 0919-1524 82.7 µM -0.769813347312095 0.215367485377264 no 2648 0.220705310529013 864 3905452
SGTC_2293 7624732 200 µM -0.770293606687701 0.215227759910599 no 2649 0.220562873983204 846 894453
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.771185171263627 0.214968509875719 no 2650 0.220298591188918 846 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2960 9079389 5.97 µM -0.771256970491627 0.214947639918142 no 2651 0.220277315943274 860 16457355
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.772129124636945 0.214694223927534 no 2652 0.220018976974621 867 165506
SGTC_506 n9-isopropylolomoucine 153 µM -0.774157843806731 0.214105424683169 no 2653 0.219418727178001 845 6610355
SGTC_2277 7947813 106.88 µM -0.774418582109802 0.214029818289414 no 2654 0.219341649202262 878 1246798
SGTC_2816 7982706 58.44 µM -0.775462074733598 0.213727391886585 no 2655 0.219033333628017 867 2981853
SGTC_532 1548-0774 215 µM -0.775653083365019 0.213672060477299 no 2656 0.218976924256594 884 5932993
SGTC_1196 1588-0294 184 µM -0.777079309121908 0.213259175039458 no 2657 0.218555990235872 868 6144269
SGTC_3274 9138298 49.47 µM -0.77802330858711 0.212986147831114 no 2658 0.218277636139044 873 17015756
SGTC_1210 3013-0140 750 nM -0.778069805394429 0.212972705115548 no 2659 0.218263931054552 849 905973
SGTC_3205 9113483 49.47 µM -0.778363250614862 0.212887878441217 no 2660 0.218177448564827 871 17018033
SGTC_1018 4259-0013 28.1 µM -0.778815621968098 0.212757149374958 no 2661 0.218044166972075 865 6801262
SGTC_3246 9135460 32.98 µM -0.779254016836545 0.212630504047786 no 2662 0.21791504804834 865 41446951
SGTC_1306 1185-0270 9.02 µM -0.779672791990951 0.212509567668128 no 2663 0.217791748836729 873 1548076
SGTC_2674 ligustilide 100 µM -0.78184495729399 0.211882921895095 no 2664 0.217152848187098 854 5319022 A signalling regulator.
SGTC_549 1661-1316 519 µM -0.78421823946182 0.21119949345369 no 2665 0.216456032254274 864 2857282
SGTC_2432 5630864 12.22 µM -0.785190435083599 0.210919905944925 no 2666 0.216170961319176 879 5714970
SGTC_1180 1193-0155 285 µM -0.786292094040257 0.210603349342987 no 2667 0.215848191561301 869 2921347
SGTC_1600 coumarin 106 71.1 µM -0.786551126042004 0.210528958196893 no 2668 0.215772339596874 868 100336 A hepatotoxic, DNA x-linker.
SGTC_789 1309-1135 70.6 µM -0.787468369142786 0.210265660070325 no 2669 0.215503868886029 851 3092424
SGTC_2098 5376439 882.5 nM -0.788890449761353 0.209857828945457 no 2670 0.215088018998987 861 2844116
SGTC_2720 fluspirilene 36.88 µM -0.789490198914234 0.20968596949011 no 2671 0.214912777981988 885 3396 An atypical antipsychotic.
SGTC_2925 9010536 32.5 µM -0.791131226935391 0.209216152491864 no 2672 0.214433709248996 824 2994177
SGTC_1540 guanosine 70.6 µM -0.791816615358284 0.209020113280638 no 2673 0.214233806359956 858 6802 Guanosine is a purine nucleoside
SGTC_2134 5324836 1.464 µM -0.791826167119153 0.209017381989052 no 2674 0.21423102122472 881 699272
SGTC_1002 4049-0206 172 µM -0.791943103523693 0.208983946149624 no 2675 0.214196926213849 862 4662749
SGTC_807 1315-0151 48 µM -0.792103739177594 0.208938020440738 no 2676 0.214150095011499 888 4011080
SGTC_958 1222-0007 33 µM -0.792375565683184 0.208860318827912 no 2677 0.214070861158219 868 7312461
SGTC_1075 aripiprazole 15.2 µM -0.792566915955902 0.208805631559993 no 2678 0.214015095302938 863 60795 An atypical antipschotic. YIL048W NEO1
SGTC_595 3909-8003 73.7 µM -0.793131956967653 0.208644193980331 no 2679 0.213850472854108 878 699517
SGTC_3326 9140064 16.379 µM -0.797028303657292 0.207532975236425 no 2680 0.212717296757357 888 1868434
SGTC_446 go6976 132 µM -0.797213619702131 0.207480211297804 no 2681 0.212663488697335 879 3501 A protein kinase C inhibitor.
SGTC_148 3253-0744 288.01 µM -0.799657592152646 0.206785095637563 no 2682 0.211954604829414 871 6893655
SGTC_2980 9014342 25.29 µM -0.802077513392184 0.206098180897271 no 2683 0.211254060789031 854 2996599
SGTC_265 mycophenolic acid 32.932 µM -0.802234492371927 0.206053667891191 no 2684 0.211208663778781 875 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3062 9077494 49.47 µM -0.803306160895498 0.205749937591585 no 2685 0.210898898937889 800 16459633
SGTC_3081 9117243 49.47 µM -0.804151383787915 0.205510573602991 no 2686 0.21065477602078 865 45595589
SGTC_894 0960-0238 55.9 µM -0.805024867958382 0.205263379935282 no 2687 0.21040266477619 883 6741907 YDL195W SEC31
SGTC_1034 k072-0165 12.7 µM -0.805430612576289 0.205148615410169 no 2688 0.210285616139188 889 5835461
SGTC_3271 9137798 49.47 µM -0.805921023842827 0.205009953902001 no 2689 0.210144194035746 826 6498326
SGTC_1270 0831-1170 17.3 µM -0.806012920778959 0.204983976669447 no 2690 0.210117699519536 864 6764716
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.806065188998549 0.204969202472133 no 2691 0.210102631109255 839 88881 An O-methylated flavonoid and antioxidant.
SGTC_331 k048-0133 24.5 µM -0.806476454380546 0.204852975796932 no 2692 0.209984089521587 864 6813582
SGTC_1997 st073024 93.8 µM -0.806912228992188 0.204729865403687 no 2693 0.2098585263806 868 686268
SGTC_644 1498-1197 63.3 µM -0.807071002813389 0.204685021258359 no 2694 0.20981278861151 886 6741615
SGTC_2943 9068529 45.32 µM -0.807657263994615 0.204519488031127 no 2695 0.209643955886504 885 3270634
SGTC_2232 chlorophetanol 41.5365 µM -0.808845393943118 0.204184259140899 no 2696 0.209302040869048 871 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_905 2-aminofluorene 215 µM -0.80898338955349 0.204145345131277 no 2697 0.209262350359866 872 1539 An established DNA mutagen. YPR165W RHO1
SGTC_454 lyso-paf C-16 6.67 µM -0.809224529676236 0.204077355536291 no 2698 0.209193003903757 877 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2402 5553605 200 µM -0.809516630403841 0.203995015638388 no 2699 0.209109020450198 893 6758546
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.810241920514559 0.203790650155948 no 2700 0.208900574251865 865 6857784
SGTC_1782 st039423 80.636 µM -0.81030730682207 0.20377223221116 no 2701 0.208881788440633 883 2068169
SGTC_3077 9117319 49.47 µM -0.810545387290069 0.203705178345685 no 2702 0.208813395148516 880 17154678
SGTC_1662 st014054 52 µM -0.813032539904156 0.203005474351358 no 2703 0.208099700987365 882 2838777
SGTC_1911 st060208 74.3 µM -0.813138650712631 0.202975654438318 no 2704 0.208069284303018 894 688783
SGTC_3229 9132204 49.47 µM -0.813794639625462 0.202791362475263 no 2705 0.20788130321597 886 17682924
SGTC_1490 4089-0339 670 nM -0.814071818230648 0.20271352263244 no 2706 0.207801904682526 863 742542
SGTC_569 4130-2812 160 µM -0.814652494220752 0.202550509757164 no 2707 0.20763562660937 874 743552
SGTC_2893 9048488 25.97 µM -0.81511242338707 0.202421449707376 no 2708 0.207503980511626 898 6467338
SGTC_565 1418-0001 44.5 µM -0.816079256811187 0.202150308376195 no 2709 0.207227403477472 892 2862145
SGTC_231 b-estradiol 524 µM -0.816688799269861 0.201979478413932 no 2710 0.207053146929147 884 450 A steroid.
SGTC_3151 9099821 49.47 µM -0.816960475566891 0.201903366443963 no 2711 0.206975507803643 872 17174189
SGTC_2000 st075254 36.4 µM -0.817471970907717 0.201760114135051 no 2712 0.206829380415631 849 17234175
SGTC_2033 5192550 145 µM -0.817840485998362 0.201656943425829 no 2713 0.206724138435298 845 182073
SGTC_3082 9117008 49.47 µM -0.817939893256046 0.201629118452538 no 2714 0.206695754753046 880 41448529
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.81866375266912 0.201426573138572 no 2715 0.206489141290787 874 688803
SGTC_841 0251-0215 91.2 µM -0.821077569547762 0.200752037476514 no 2716 0.205801042803746 883 3888614
SGTC_120 rhodamine 6G 52.259 µM -0.822901371043892 0.200243280640409 no 2717 0.205282041490738 904 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_347 4534-1311 26.2 µM -0.826675222135274 0.199193012822928 no 2718 0.204210584495853 884 2862016
SGTC_1288 0973-0013 65.5 µM -0.827111926744412 0.199071691905012 no 2719 0.20408681239386 877 4315430
SGTC_2187 6125751 200 µM -0.828104802338566 0.198796026834641 no 2720 0.203805575029807 883 874498
SGTC_2997 9067075 71.4286 µM -0.828600554961276 0.198658470716505 no 2721 0.203665236939623 874 27209819
SGTC_1308 1187-1617 41.4 µM -0.828866839962169 0.198584608513466 no 2722 0.203589880539327 883 2882570
SGTC_1178 0988-0033 191 µM -0.829115757515209 0.198515578678551 no 2723 0.203519454018491 872 5392207
SGTC_2433 5607874 27.82 µM -0.829770549384986 0.198334060881161 no 2724 0.20333426242718 874 2252428
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.832413958228558 0.197602288628086 no 2725 0.20258766299837 881 5355888
SGTC_2490 carminic acid 95.39 µM -0.832844369294443 0.197483293051213 no 2726 0.202466253814981 871 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2226 7298446 200 µM -0.833587326618033 0.1972779899072 no 2727 0.202256784818507 882 3283010
SGTC_2491 paeonol 100 µM -0.834996487907054 0.196888947896087 no 2728 0.201859842917744 900 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1395 3486-0190 4.35 µM -0.835039784049813 0.196877002033288 no 2729 0.201847654363041 881 6748079
SGTC_119 0121-0043 24.815 µM -0.836106106583324 0.196582930902653 no 2730 0.201547606650967 897 1092378
SGTC_2586 curcumin 80 µM -0.836143350337854 0.196572664607538 no 2731 0.20153713163015 907 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2321 7390090 138.78 µM -0.838693706051682 0.19587042827762 no 2732 0.200820605572772 903 649046
SGTC_3159 9100096 49.47 µM -0.838981079351122 0.195791396044703 no 2733 0.200739963585677 878 25236875
SGTC_1353 1498-1206 8.11 µM -0.839110213374796 0.195755888435452 no 2734 0.200703732644714 851 6756808
SGTC_1032 k061-1018 98.7 µM -0.840801784653522 0.195291122990052 no 2735 0.200229493595293 904 4005393
SGTC_16 erodoxin 22.806 µM -0.84142122488215 0.195121097349428 no 2736 0.200055999529903 867 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3201 9113999 49.47 µM -0.842390850405939 0.194855132612821 no 2737 0.199784606380255 891 16649224
SGTC_2765 myclobutanil 7.74 µM -0.845992459820463 0.193869156328278 no 2738 0.198778475320416 898 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1222 0366-0074 1.18 µM -0.851983071035361 0.192235917355705 no 2739 0.197111744054627 898 286520
SGTC_456 gingerol 170 µM -0.853074573140204 0.191939246733753 no 2740 0.196808975441307 900 442793 A herb.
SGTC_960 1222-0186 7.7 µM -0.854832283400121 0.191462089912267 no 2741 0.196322001576747 896 3126296
SGTC_421 streptovitacin 30 mM -0.855211205903322 0.191359321023955 no 2742 0.196217116831769 914 91467 include heat shock
SGTC_3182 9108849 49.47 µM -0.857105196023297 0.190846152350038 no 2743 0.195693374907743 880 17133045
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.858119730289959 0.190571616152897 no 2744 0.195413176816274 869 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1386 3228-0095 33.8 µM -0.858252559962753 0.190535689979323 no 2745 0.195376509441514 893 870181
SGTC_2477 5967686 25.23 µM -0.8582542269657 0.190535239134821 no 2746 0.195376049295126 902 776118
SGTC_3091 9116372 49.47 µM -0.859620516173827 0.190165943587068 no 2747 0.194999130985374 897 17169793
SGTC_3297 9117502 71.43 µM -0.860051046264937 0.190049666407425 no 2748 0.194880452278563 869 7453720
SGTC_1833 st055984 71 µM -0.860405240039412 0.18995403884118 no 2749 0.194782849165876 882 676288
SGTC_2617 dihydrotanshinone i 20.83 µM -0.861888032056339 0.189554026101367 no 2750 0.194374567715387 875 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2555 cholic acid 100 µM -0.862672086956355 0.189342721280128 no 2751 0.194158891764651 878 6708657 Influences liver metabolism.
SGTC_2681 menadione 3.18 µM -0.863394466996243 0.189148166380916 no 2752 0.193960310260897 902 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1248 0469-0687 58.6 µM -0.863626541175867 0.189085689173109 no 2753 0.193896539593166 897 4017482
SGTC_2516 gossypol 71.55 µM -0.863823089809926 0.189032785818372 no 2754 0.193842540832795 903 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_778 3456-2434 196 µM -0.866022831805834 0.188441321818675 no 2755 0.193238820594006 836 5539063
SGTC_200 k038-0079 37.545 µM -0.866910138986157 0.18820306712799 no 2756 0.192995623887031 914 3436683
SGTC_392 N-ethylmaleimide 8.33 µM -0.86997647010227 0.187381145353783 no 2757 0.192156631583018 874 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_698 k064-0052 127 µM -0.870268642598964 0.187302945257544 no 2758 0.192076805587934 937 5088751
SGTC_53 0973-0023 39.979 µM -0.872239146723435 0.18677606605071 no 2759 0.191538963799657 905 674768
SGTC_262 fenpropimorph 62.5 µM -0.872849366314182 0.186613089946338 no 2760 0.19137259390333 918 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_851 0394-0702 453 µM -0.872956499177348 0.186584486226312 no 2761 0.191343394406489 904 762646
SGTC_2315 7733312 200 µM -0.873166425592365 0.18652844522419 no 2762 0.191286186027559 893 726316
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.873216343736357 0.186515120837433 no 2763 0.191272584060576 898 688798
SGTC_1239 0337-0584 35.4 µM -0.873614445206209 0.186408878809975 no 2764 0.191164128429221 910 914301 YML130C ERO1
SGTC_3125 9127534 49.47 µM -0.874511547417288 0.186169605045868 no 2765 0.190919867215334 873 1639235
SGTC_2646 retinol 96.75 µM -0.877268556179475 0.18543545192714 no 2766 0.190170393467405 878 445354 A vitamin A analog and teratogen.
SGTC_1686 st019653 115.5 µM -0.8774588775469 0.185384838389413 no 2767 0.19011872271151 914 97252
SGTC_258 haloperidol 50.781 µM -0.878300639625351 0.185161085375441 no 2768 0.189890294398633 899 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_835 0312-0010 67.2 µM -0.878813667046371 0.185024797278628 no 2769 0.189751157347816 905 1626196
SGTC_1951 sophoraflavanone G 9.2 µM -0.880893398567563 0.184472945704618 no 2770 0.189187760424497 889 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.880947506386515 0.18445860200766 no 2771 0.189173116438367 879 6708739 YPR165W RHO1
SGTC_2409 alverine citrate 63.97 µM -0.884265584822808 0.18358032300513 no 2772 0.188276430820976 881 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2707 st078556 66.6 µM -0.884712895838618 0.183462121649208 no 2773 0.188155749302807 874 17250899
SGTC_364 0083-0097 67.7 µM -0.886176813719552 0.183075615040346 no 2774 0.187761127931015 926 5207356
SGTC_2871 9038510 12.99 µM -0.887728752316439 0.182666424189394 no 2775 0.187343337911004 900 4945164
SGTC_2640 pentamidine 10.38 µM -0.888964861156975 0.182340915282002 no 2776 0.187010982430112 871 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2366 9070441 60.58 µM -0.889686950445361 0.182150932766201 no 2777 0.186817001476252 895 6837235
SGTC_2805 7950783 58.44 µM -0.889789502429644 0.182123961259722 no 2778 0.186789462171591 892 1178958 YDL195W SEC31
SGTC_1763 st044482 94.5 µM -0.890752885613499 0.181870710238347 no 2779 0.186530877989144 891 88505
SGTC_2308 7584454 197.62 µM -0.891689049715262 0.181624825600298 no 2780 0.186279812244375 904 893577
SGTC_607 4491-0986 66.8 µM -0.892771689241993 0.181340728544054 no 2781 0.185989725126204 875 698981 YDR232W HEM1
SGTC_2611 pyromycin 23.93 µM -0.895364238939319 0.180661545430425 no 2782 0.185296205348539 894 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_172 1112-0046 2.638 µM -0.896394251303859 0.180392151299907 no 2783 0.185021118260116 929 2802135 YIL048W NEO1
SGTC_1717 st033143 58.0435 µM -0.897170680063574 0.180189247268673 no 2784 0.184813923968581 900 674616
SGTC_3045 9092950 49.47 µM -0.89777882078478 0.180030422011991 no 2785 0.184651739026071 885 44120432
SGTC_2891 9063876 19.48 µM -0.897895661887154 0.17999991723922 no 2786 0.184620588830514 885 6472478
SGTC_941 3237-0776 460 µM -0.898881453602142 0.17974267682302 no 2787 0.184357903842909 899 760008
SGTC_1962 st076595 64.5 µM -0.901995982561157 0.178931465172486 no 2788 0.183529500926053 892 279619
SGTC_2352 9027995 87.8 µM -0.903628742940166 0.178507117661999 no 2789 0.183096147461391 903 2997347
SGTC_1813 st051246 8.6015 µM -0.903789478206309 0.17846537754712 no 2790 0.183053521005523 881 5291959
SGTC_990 3985-0011 41.3 µM -0.905437975812954 0.178037646718458 no 2791 0.182616702382193 905 5399565 YGL099W LSG1
SGTC_1695 st026914 34.495 µM -0.906342414312257 0.177803249541001 no 2792 0.182377321185561 905 3289191
SGTC_3345 9148410 3.559 µM -0.908111362568233 0.177345366246592 no 2793 0.181909693903173 880 4903596
SGTC_3157 9099274 49.47 µM -0.910048477197354 0.176844808814473 no 2794 0.181398472316494 877 17217662
SGTC_1853 st056710 91.2 µM -0.910818470814826 0.176646087947884 no 2795 0.18119551430188 912 269167
SGTC_601 0986-0029 62.9 µM -0.911501476395567 0.176469935278717 no 2796 0.181015604028532 884 24747981
SGTC_3127 9126946 49.47 µM -0.912647647258553 0.176174578319163 no 2797 0.180713943159645 886 27243249
SGTC_2044 5102272 200 µM -0.91458228044496 0.17567675261207 no 2798 0.180205482264748 902 592666
SGTC_2567 aureobasidin a 60 nM -0.917106388617151 0.175028582863346 no 2799 0.179543446829786 904 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.917922868515521 0.174819242877983 no 2800 0.179329624120917 902 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2058 5236698 133 µM -0.918556516383927 0.174656889373015 no 2801 0.179163792525944 882 766665
SGTC_917 harmaline 728.087 nM -0.918940738506363 0.17455849046944 no 2802 0.179063284983405 879 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_558 k064-0027 21.3 µM -0.920821223234725 0.174077408139624 no 2803 0.17857188629476 875 5088526
SGTC_1299 1079-1439 3.74 µM -0.921955514005529 0.173787631703388 no 2804 0.178275890259795 920 323161
SGTC_203 k066-0004 30.888 µM -0.922266902693063 0.173708135169228 no 2805 0.178194686718608 932 6795412
SGTC_3309 9129340 25.759 µM -0.923134838911984 0.173486675962278 no 2806 0.177968470503692 891 17158987
SGTC_160 3453-0671 289.699 µM -0.92368017517071 0.173347622061808 no 2807 0.177826428424529 929 5322268
SGTC_873 0591-4978 488 µM -0.924225090929062 0.173208746279011 no 2808 0.177684567319998 904 3305145
SGTC_1063 disulfiram 1.84 µM -0.929404026036378 0.171892394956106 no 2809 0.176339871066534 932 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2002 4023503 131 µM -0.930259071808345 0.171675680427197 no 2810 0.176118481673625 930 4736863 YCR052W RSC6
SGTC_54 0159-0055 9 µM -0.930779761423855 0.171543795254177 no 2811 0.175983750378351 900 3319099
SGTC_152 4469-0003 551.229 µM -0.930822611359419 0.171532944702553 no 2812 0.175972665629526 890 697280
SGTC_1473 k844-0725 134 µM -0.93105221633001 0.171474811115845 no 2813 0.175913277192451 903 54682906
SGTC_818 4072-2707 53.5 µM -0.934180585338592 0.170683995439052 no 2814 0.175105374353601 915 882871
SGTC_123 0083-0120 66.675 µM -0.934690774284059 0.170555247307213 no 2815 0.174973841378162 934 16001701
SGTC_1703 st026983 48.3 µM -0.936921571908691 0.169993027588203 no 2816 0.174399450967 901 1104023
SGTC_589 1227-0070 34.1 µM -0.937591925506934 0.169824313233926 no 2817 0.174227081249584 893 2841384
SGTC_2219 9098279 200 µM -0.938065952136907 0.169705075210805 no 2818 0.174105258951731 887 902349
SGTC_1027 k015-0025 8.67 µM -0.939597748367926 0.169320130001033 no 2819 0.173711965839447 916 3598955
SGTC_65 0798-0905 34.986 µM -0.940892926016959 0.168995085439075 no 2820 0.173379866560536 949 3602145
SGTC_1019 4262-0212 3.4 µM -0.941951478617198 0.16872972338799 no 2821 0.173108741182761 912 4677213
SGTC_1 0258-0098 57.368 µM -0.943891577092004 0.168244067568101 no 2822 0.17261252833832 874 6790032 YDR047W HEM12
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.944193863284505 0.168168478721743 no 2823 0.17253529529687 886 756377
SGTC_3059 1327-0034 3 µM -0.944482622368746 0.168096292834749 no 2824 0.17246153896629 899 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2357 9067248 200 µM -0.945629489197496 0.167809788443361 no 2825 0.172168798922374 952 9150235
SGTC_442 cape 100 µM -0.94952698023391 0.166838488561544 no 2826 0.171176328264944 916 5281787
SGTC_2342 7990637 118.86 µM -0.951160251261843 0.166432539047549 no 2827 0.170761516428782 954 2033102 YER133W GLC7
SGTC_1946 st076057 65.1 µM -0.951643684741386 0.166312504075569 no 2828 0.170638859367968 894 953009
SGTC_2852 9023854 51.95 µM -0.951769173533816 0.166281354755599 no 2829 0.170607029491689 911 19798528
SGTC_2823 7987624 58.44 µM -0.951866420132421 0.166257218415146 no 2830 0.170582365782153 911 2239440
SGTC_1972 st070201 17.4 µM -0.955340268589719 0.165396503018361 no 2831 0.169702824874127 919 2829099
SGTC_1062 mesoridazine 14.2 µM -0.956695688762706 0.165061453843238 no 2832 0.169360437404308 897 4078 A neuroleptic.
SGTC_1815 st051655 58.2 µM -0.958260002978956 0.164675314312601 no 2833 0.16896583355358 924 5984156
SGTC_1974 st069448 26.9 µM -0.958302967667373 0.164664717058066 no 2834 0.168955003897082 903 6323587 YNR016C ACC1
SGTC_3216 9129716 49.47 µM -0.95854989423887 0.164603821105263 no 2835 0.168892772362018 909 8056934
SGTC_480 am 92016 50 µM -0.958609857060259 0.164589035538552 no 2836 0.168877662487006 938 2129 K+ channel blocker.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.960496042938954 0.164124381252987 no 2837 0.16840281078995 894 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_358 0075-0058 9.45 µM -0.963557119936782 0.163372109999622 no 2838 0.167634006867944 960 1069125
SGTC_320 4092-0846 5.34 µM -0.963950588153851 0.163275576410844 no 2839 0.167535349687637 899 1359356
SGTC_736 0958-0254 92.6 µM -0.965029535769841 0.163011057325727 no 2840 0.167265009170487 931 6812352
SGTC_1117 retinoic acid 1.10837 µM -0.96967580394458 0.161875144523675 no 2841 0.166104057389661 939 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_522 1273-0010 11.6 µM -0.970022165693143 0.161790673560201 no 2842 0.16601772181925 882 5705015
SGTC_1927 st060202 13.8 µM -0.970231966103131 0.161739521249933 no 2843 0.165965440200318 890 688887
SGTC_1961 st076550 68.7 µM -0.971516245157883 0.161426625591694 no 2844 0.165645633743185 919 1579337
SGTC_2375 9072683 200 µM -0.97175423695131 0.161368685780585 no 2845 0.16558641369493 921 16798029
SGTC_2940 9060638 45.86 µM -0.97239102585285 0.161213724328421 no 2846 0.165428027381364 905 4027022
SGTC_1693 xanthone 101.9 µM -0.973786519959929 0.160874472908813 no 2847 0.165081273791276 929 7020 An insecticide.
SGTC_1629 st005085 44.9 µM -0.975293985536703 0.160508524708571 no 2848 0.164707226512368 901 24207091
SGTC_3155 9099265 49.47 µM -0.97549603436612 0.160459517252312 no 2849 0.164657133919412 925 25236499
SGTC_2976 9009005 19.48 µM -0.976006126478939 0.160335836616566 no 2850 0.164530714171425 872 2993148
SGTC_201 4262-0159 12.803 µM -0.978485782424253 0.159735489033532 no 2851 0.163917059880594 940 1341029
SGTC_1167 k781-0610 148 µM -0.979141236636689 0.159577043607329 no 2852 0.163755099462563 907 4525169
SGTC_1432 4049-0298 68.4 µM -0.979542204836447 0.159480166775242 no 2853 0.163656072864105 932 741646
SGTC_965 1291-5240 308 µM -0.980690902558215 0.159202846232927 no 2854 0.163372595748468 946 2834598
SGTC_994 3910-0338 138 µM -0.981182063401533 0.1590843658097 no 2855 0.163251483846016 915 3479481
SGTC_1087 pterostilbene 9.05 µM -0.981330409489566 0.159048592340848 no 2856 0.163214915699689 931 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1315 1237-0019 3.69 µM -0.983557105013031 0.158512260908645 no 2857 0.162666662332522 920 825140
SGTC_2283 7944793 200 µM -0.983602050987198 0.158501447255966 no 2858 0.1626556081566 892 2970533
SGTC_662 k832-1615 104 µM -0.985869343679542 0.157956582055571 no 2859 0.162098616079456 931 5878478
SGTC_1702 st027038 51 µM -0.986138588713805 0.157891960133374 no 2860 0.162032554889765 926 5521182
SGTC_1332 1480-0653 17.5 µM -0.989723400726008 0.157033218339572 no 2861 0.161154666959763 932 5749438
SGTC_2863 9028737 58.44 µM -0.989889851294899 0.156993419876545 no 2862 0.161113980259258 917 6460917
SGTC_122 0236-0016 402.397 µM -0.990306333285772 0.156893867775707 no 2863 0.161012205963787 920 6808838
SGTC_1613 st002381 52.1 µM -0.991364011639392 0.156641236590363 no 2864 0.160753933303665 919 551167
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.993424507238952 0.156149847422586 no 2865 0.160251561697991 930 7104
SGTC_116 0155-0182 31.788 µM -0.996180210610741 0.155494253616014 no 2866 0.159581296405323 839 771486
SGTC_1708 st033234 31.827 µM -0.997858874632407 0.155095783458854 no 2867 0.159173898234969 921 674664
SGTC_2356 9061756 188.97 µM -1.00170352448684 0.154185708383344 no 2868 0.158243401975969 922 20104043
SGTC_1898 st060199 18.6 µM -1.00349224895009 0.153763502046037 no 2869 0.157811707433418 901 688866
SGTC_3171 9103192 49.47 µM -1.00368236992861 0.153718671372607 no 2870 0.157765868751336 940 13018434
SGTC_868 0527-0199 213 µM -1.0037494617683 0.153702853130818 no 2871 0.157749694815148 928 2849450
SGTC_197 4544-0043 41.561 µM -1.00620032370299 0.153125752163379 no 2872 0.15715960824599 941 896523
SGTC_745 0469-0705 296 µM -1.00662067010453 0.153026918258673 no 2873 0.157058548735139 937 3486736
SGTC_91 0417-1751 58.384 µM -1.00822986430946 0.152648947533092 no 2874 0.156672062028682 952 6795624
SGTC_927 2425-1185 123 µM -1.00851044619898 0.152583107364079 no 2875 0.156604737683969 936 730375
SGTC_3145 9085516 49.47 µM -1.00858050436687 0.152566670748329 no 2876 0.156587930517924 943 25236195
SGTC_3010 9080089 71.4286 µM -1.00927680066484 0.152403373862556 no 2877 0.156420951487294 922 17027233
SGTC_2020 4017018 200 µM -1.01043641475588 0.152131676262656 no 2878 0.156143124427666 958 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1440 4100-1550 40 µM -1.01060237169741 0.152092818874811 no 2879 0.156103390115085 936 742806
SGTC_2737 bleomycin 30.5 nM -1.01115738882173 0.151962914282778 no 2880 0.155970553306887 931 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_481 bay k-8644 50 µM -1.01124011487197 0.151943558141597 no 2881 0.155950760183804 937 2303 A calcium channel antagonist.
SGTC_2445 5742597 35.57 µM -1.01238606843099 0.151675597798368 no 2882 0.15567674843785 933 1774255
SGTC_2642 cholecalciferol 100 µM -1.01337321597583 0.151445023304551 no 2883 0.155440963903136 908 9821465 A vitamin D precursor, similar to steriods.
SGTC_1481 3346-2004 36 µM -1.01385030253674 0.151333670666972 no 2884 0.155327094180431 938 2770522
SGTC_3335 9143315 29.6265 µM -1.01456398497647 0.151167197914939 no 2885 0.155156857194137 909 4899691
SGTC_845 0330-0138 4.51 µM -1.01584860959461 0.15086785496409 no 2886 0.15485074202999 921 9039800
SGTC_1591 genipin 88.4 µM -1.01593699611538 0.150847273674386 no 2887 0.154829694949608 953 442424 A DNA cross-linking agent.
SGTC_1809 st050081 57.6 µM -1.01960148041095 0.14999562332559 no 2888 0.153958751307907 923 5036894
SGTC_3036 9090181 49.47 µM -1.02113550742322 0.149640059138066 no 2889 0.153595121212344 941 25236586
SGTC_3202 9113761 49.47 µM -1.0216134477505 0.149529394819482 no 2890 0.153481945176956 935 4798415
SGTC_519 k048-0011 62.8 µM -1.02161479202467 0.14952908363762 no 2891 0.153481626931405 918 6836379
SGTC_2949 9072542 2.23 µM -1.02381237386838 0.149020950056659 no 2892 0.152961952349034 956 16457352
SGTC_2141 5621638 7.665 µM -1.02697475335427 0.148291758702681 no 2893 0.152216176165469 942 2856238
SGTC_1352 1496-0991 99 µM -1.02720023357113 0.148239858086034 no 2894 0.152163094078171 963 3000039
SGTC_2684 capsaicin 100 µM -1.02739599064479 0.148194808943582 no 2895 0.152117019321071 933 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1035 k081-0041 55.2 µM -1.02977266034356 0.147648601921927 no 2896 0.151558368782173 914 731709
SGTC_396 dithiazanine 1.25 µM -1.03033967546849 0.147518489790492 no 2897 0.151425290227323 928 10578 An antihelmenthic.
SGTC_2395 5646831 180.19 µM -1.03411898059458 0.146653220822956 no 2898 0.150540271986771 965 6808628
SGTC_773 4358-1457 44.6 µM -1.03451987945167 0.146561635547376 no 2899 0.150446594087513 962 1186886
SGTC_1860 st056228 74.6 µM -1.03491449491509 0.146471523209461 no 2900 0.150354422361991 954 688679
SGTC_1724 st037281 8.293 µM -1.0391676308631 0.145502659962111 no 2901 0.149363390881163 924 574124 YDL195W SEC31
SGTC_1450 4112-4260 37.6 µM -1.03961941003908 0.145399998593509 no 2902 0.149258377736031 923 1633175
SGTC_2659 sanguinarine 24.21 µM -1.04121840469833 0.145037037810279 no 2903 0.148887097883797 915 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2170 morpholine 200 µM -1.04145156153693 0.144984163804648 no 2904 0.148833011441627 939 121171 Reacts with secondary amines.
SGTC_465 cgp-37157 41 µM -1.0422456589111 0.144804180202282 no 2905 0.148648899620423 905 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1742 st038235 28.8875 µM -1.04266988869853 0.144708089442473 no 2906 0.148550604181916 935 564103 YBR002C RER2
SGTC_3139 9095020 49.47 µM -1.04422499015608 0.144356216349015 no 2907 0.14819065377449 867 25236292
SGTC_2655 perillic acid 100 µM -1.04530792947476 0.144111520360302 no 2908 0.147940337001395 949 5702197 An apoptosis inducer.
SGTC_1300 1094-0077 113 µM -1.0459550823673 0.143965426250924 no 2909 0.14779088557666 944 5532636
SGTC_1212 0520-0165 585 µM -1.04710022949407 0.143707155295114 no 2910 0.147526676748182 975 5403258
SGTC_1492 4158-0558 28.5 µM -1.04821038798583 0.143457074156741 no 2911 0.147270842768223 907 3967268
SGTC_2201 6605497 169.863 µM -1.04999710235858 0.143055205155728 no 2912 0.146859722492922 944 670741
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.05443559762907 0.142060190023349 no 2913 0.145841765829286 947 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_162 k030-0015 37.8 µM -1.05443716839515 0.142059838722669 no 2914 0.145841406419879 961 1809920 YMR134W ERG29
SGTC_2068 5226020 147 µM -1.05529377864764 0.141868346067833 no 2915 0.145645492785625 966 1810509
SGTC_2544 sphondin 68.51 µM -1.05529555270604 0.14186794966385 no 2916 0.145645087227933 926 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_553 k007-0256 45.7 µM -1.05561109735887 0.141797454807686 no 2917 0.145572964385586 943 6287000
SGTC_3178 9107506 49.47 µM -1.05711145174991 0.141462589867468 no 2918 0.145230362692977 941 8897194
SGTC_2806 7952793 58.44 µM -1.05974848480455 0.140875328587315 no 2919 0.144629519359594 937 2972490
SGTC_630 4356-0227 183 µM -1.0640183702661 0.139927946297346 no 2920 0.143660188848206 943 779312
SGTC_1698 5-fluorocytosine 1.055 µM -1.06529173402238 0.139646258385705 no 2921 0.143371966106243 942 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_832 4083-0019 164 µM -1.06537711570317 0.139627384430675 no 2922 0.143352654151603 949 1990758
SGTC_3217 9129673 49.47 µM -1.06639838162258 0.139401764055979 no 2923 0.143121796484579 959 17248312
SGTC_984 1492-0255 2.91 µM -1.07181980696059 0.13820820452181 no 2924 0.141900487437958 958 1585198
SGTC_13 0199-0087 65 µM -1.07226551831531 0.138110389362066 no 2925 0.141800394884899 946 4589825
SGTC_1414 3917-0015 5.4 µM -1.07432709102346 0.137658573873533 no 2926 0.141338053551137 945 6618702
SGTC_3195 9113082 49.47 µM -1.07873551222541 0.136695809691461 no 2927 0.140352824972241 941 17018038
SGTC_55 0767-0285 6.563 µM -1.07932917702799 0.136566510602029 no 2928 0.140220505277606 944 3116166
SGTC_686 1319-0111 510 µM -1.08128316830741 0.136141525760346 no 2929 0.139785586128507 961 4562600
SGTC_284 0988-0104 32.6 µM -1.08251106201768 0.135874927664895 no 2930 0.139512751366813 953 4666532
SGTC_1168 k815-0004 80.5 µM -1.08563819714366 0.135197584980289 no 2931 0.138819546758211 961 642433
SGTC_1289 0976-0073 69.1 µM -1.08667802282434 0.134972870754609 no 2932 0.138589564971332 957 3391136
SGTC_2268 7933382 153.85 µM -1.08680634225105 0.134945157720218 no 2933 0.138561202130764 939 935025 YOR257W CDC31
SGTC_870 0573-2213 57.6 µM -1.08681358854641 0.134943592860579 no 2934 0.138559600577625 940 3916321
SGTC_440 fluspirilene 35.1 µM -1.08724506784721 0.13485043602294 no 2935 0.138464259130613 969 3396 An atypical antipsychotic.
SGTC_2761 levamisole 97.89 µM -1.08741061995537 0.134814704861943 no 2936 0.138427689923698 940 26879 An alkaline phosphatase inhibitor.
SGTC_3254 9136651 49.47 µM -1.0886691197615 0.134543294851833 no 2937 0.138149912055161 964 16454030
SGTC_329 k048-0121 21.3 µM -1.08987695977297 0.134283163166585 no 2938 0.137883673553608 959 6832902
SGTC_2157 5649910 96.377 µM -1.0902402547876 0.134204988181175 no 2939 0.137803662659571 949 2858091
SGTC_1552 6-methylflavone 10.6 µM -1.09089537769534 0.134064095758653 no 2940 0.13765946063674 950 689013
SGTC_2 0422-0095 29 µM -1.09105510559211 0.134029759679827 no 2941 0.137624317838866 930 6790840
SGTC_1863 st057641 20.1 µM -1.09341065679788 0.133524097639638 no 2942 0.137106768317128 973 3921635
SGTC_416 estradiol valerate 100 µM -1.0941536140889 0.133364880824935 no 2943 0.136943805778068 959 13791 A steroid.
SGTC_1658 st012944 20 µM -1.09470087905155 0.133247684724867 no 2944 0.136823851692681 951 24207260
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.09495563536279 0.133193153161864 no 2945 0.13676803659185 940 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2784 7567673 72.73 µM -1.09720195515294 0.132712984530142 no 2946 0.136276559340851 930 3471247
SGTC_2467 5474540 200 µM -1.09743836122337 0.132662520290394 no 2947 0.136224905907521 924 5413519
SGTC_1640 st009078 66.4 µM -1.10036637702647 0.132038589248392 no 2948 0.135586260996694 953 690618
SGTC_1925 st057770 10.1 µM -1.10101766130947 0.131900082615651 no 2949 0.13544448529496 951 5989122
SGTC_2408 sulbentine 18.36 µM -1.10121072064404 0.131859044542824 no 2950 0.135402478440305 928 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_82 0054-0107 293.755 µM -1.10329982668759 0.131415532542602 no 2951 0.134948490931136 947 3104697
SGTC_1899 st063254 59.6 µM -1.10434855566213 0.131193278715071 no 2952 0.134720983759001 947 3093813
SGTC_1273 0849-0096 14.1 µM -1.10557362428005 0.130933982717063 no 2953 0.134455555627876 974 5286025
SGTC_312 4092-0653 6.84 µM -1.10597869028731 0.130848325073283 no 2954 0.134367871487106 933 1148278
SGTC_730 1436-0052 41.2 µM -1.10616096464548 0.130809792901472 no 2955 0.134328427593389 939 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_259 usnic acid 108.925 µM -1.10666047765395 0.130704237769467 no 2956 0.134220374493933 987 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2442 5158906 48.48 µM -1.10703776729689 0.130624549444176 no 2957 0.134138799957946 932 1893835
SGTC_1839 st053978 48 µM -1.10751381885166 0.130524049300133 no 2958 0.134035920521296 972 3788398
SGTC_2886 9058944 51.95 µM -1.1094085864337 0.130124571353547 no 2959 0.133626979949556 927 4949929
SGTC_2785 7756463 72.73 µM -1.11267950907305 0.129436948373357 no 2960 0.132923049533761 957 2201551
SGTC_1218 1348-1416 30.7 µM -1.11537259567201 0.128872692835927 no 2961 0.132345393978252 939 6787668
SGTC_1947 st076332 61.6 µM -1.11615606038454 0.128708862151039 no 2962 0.132177669524315 950 24208416
SGTC_1875 nocodazole 6 µM -1.11627806641336 0.128683362420931 no 2963 0.132151563616006 955 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2040 5100729 123 µM -1.11741290631907 0.128446344446777 no 2964 0.131908909648225 959 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3006 9075424 71.4286 µM -1.11784719873904 0.128355720152126 no 2965 0.131816129649318 955 7465181
SGTC_626 0214-0009 33 µM -1.11892652751965 0.128130687670343 no 2966 0.131585742415472 965 3437874
SGTC_156 3474-0145 5.642 µM -1.12010815337354 0.12788464134262 no 2967 0.131333838291387 919 2265471
SGTC_830 4076-0286 57.8 µM -1.12232246269905 0.127424447029236 no 2968 0.13086267936861 947 6866659
SGTC_38 0929-0051 58.268 µM -1.12276868070326 0.127331850268566 no 2969 0.130767875063579 958 1379719
SGTC_1286 0929-0070 131 µM -1.12448059479096 0.126977037339412 no 2970 0.130404599124369 958 1420408
SGTC_2670 beta-carotene 100 µM -1.12524820936198 0.126818164489156 no 2971 0.130241934712065 911 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1207 2099-0101 141 µM -1.12557190686365 0.12675121046233 no 2972 0.130173382408379 943 5837381
SGTC_1188 1403-0014 4.57 µM -1.1277121658178 0.126309135810123 no 2973 0.129720749026412 937 9614867
SGTC_2331 7980721 200 µM -1.12779495567809 0.126292057015245 no 2974 0.129703262109198 942 2981221
SGTC_2894 9048625 32.47 µM -1.1287573528461 0.126093641320314 no 2975 0.129500103873983 949 4092861
SGTC_1932 st074806 40.9 µM -1.13580972339207 0.124646297305238 no 2976 0.128018103389273 954 17251235
SGTC_2119 5528445 120.635 µM -1.13604939729063 0.124597314369518 no 2977 0.127967945654872 976 791935
SGTC_1999 st074831 12.5 µM -1.13766210962477 0.124268068975055 no 2978 0.127630800448671 956 17112523
SGTC_1627 st003713 25.6 µM -1.13794653115313 0.124210065709764 no 2979 0.127571404885791 971 16195070 YER133W GLC7
SGTC_1505 k297-0037 20.6 µM -1.14264982236307 0.123253649161277 no 2980 0.126592005435818 955 4089396
SGTC_1322 1348-1070 12 µM -1.14342916058426 0.123095670092988 no 2981 0.12643022550496 947 6758089
SGTC_751 0833-0568 350 µM -1.14440273331626 0.122898517363528 no 2982 0.126228327596493 969 6954252
SGTC_2057 5236571 38.335 µM -1.14445011890207 0.122888927229141 no 2983 0.126218506589816 953 54684039 YBR257W POP4
SGTC_477 mead ethanolamide 10 µM -1.14517025582267 0.122743246860119 no 2984 0.126069318530614 976 16061185
SGTC_1301 naphtanilide LB 4.81 µM -1.14772421479304 0.122227569470876 no 2985 0.125541215767348 950 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2425 5628681 7.85 µM -1.14916444815604 0.121937439306787 no 2986 0.125244088742582 965 5714958
SGTC_1274 0865-0114 173 µM -1.14940414384805 0.121889200407397 no 2987 0.125194686074133 961 870624
SGTC_788 1182-0090 188 µM -1.15359036672538 0.12104888145864 no 2988 0.1243340748303 963 5715185
SGTC_186 3455-3465 67.277 µM -1.15469197763553 0.120828429237935 no 2989 0.124108292947656 950 755278
SGTC_1054 3429-0080 167 µM -1.15594547804196 0.120577925059018 no 2990 0.123851729485686 990 1162877
SGTC_2944 9067346 25.62 µM -1.15952184390508 0.119865221592845 no 2991 0.123121768947735 954 6473075
SGTC_1460 k062-0059 9.15 µM -1.16077393623292 0.119616406100794 no 2992 0.122866922494609 938 1373085
SGTC_290 2043-6722 48.1 µM -1.16229225916682 0.119315174334022 no 2993 0.122558384929293 961 773758 YLR208W SEC13
SGTC_1049 3226-0134 66 µM -1.16296381185148 0.11918211073174 no 2994 0.122422092612134 963 5702385
SGTC_2274 7947094 46.08 µM -1.16380196524976 0.119016183329607 no 2995 0.122252137774457 969 2971028
SGTC_2536 dehydroabietamide 32.04 µM -1.16563853897925 0.118653171294084 no 2996 0.121880309583523 970 3983547
SGTC_3186 9110464 49.47 µM -1.16679453280688 0.118425082346629 no 2997 0.121646677708639 974 17018021
SGTC_2967 9089538 49.85 µM -1.16871360319859 0.118047115532399 no 2998 0.121259519693433 973 728216
SGTC_2133 5320837 200 µM -1.17097315918205 0.117603183781291 no 2999 0.1208047830788 992 2841355
SGTC_1874 staurosporine 7.6 µM -1.17225306846235 0.117352246759138 no 3000 0.120547733924717 957 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1189 1431-2119 7.28 µM -1.17344433492108 0.117119029840734 no 3001 0.120308833526383 970 3107275
SGTC_2101 5377231 179.231 µM -1.17373439652316 0.117062293573184 no 3002 0.12025071416854 986 2844213
SGTC_2418 pentamidine 31.67 µM -1.17630454351305 0.116560421568723 no 3003 0.119736600408052 913 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1642 st009582 77.7 µM -1.17829726563375 0.116172354780575 no 3004 0.119339058760008 970 6739311
SGTC_1256 0570-0116 285 µM -1.1816661079162 0.115518386570412 no 3005 0.118669105673544 975 410638
SGTC_208 k072-0098 12.366 µM -1.18527420864851 0.114820878504484 no 3006 0.117954523730773 982 5948901
SGTC_1232 0279-0259 161 µM -1.19039791347704 0.113835534382325 no 3007 0.116945016381317 961 1560000
SGTC_3107 9121808 49.47 µM -1.19387677832852 0.113169954862882 no 3008 0.116263086198823 909 662681
SGTC_171 k064-0041 9.68 µM -1.19680904010233 0.112611112180383 no 3009 0.115690496944626 947 53325
SGTC_699 0375-0592 111 µM -1.20003412073443 0.111998741969424 no 3010 0.115063044586541 945 762578
SGTC_710 3448-4187 58 µM -1.20177944055525 0.111668339637001 no 3011 0.114724496523266 967 3946412
SGTC_2078 5212016 200 µM -1.20236094088428 0.111558412215717 no 3012 0.114611857678189 971 1899708
SGTC_1337 1486-1011 40.3 µM -1.2037173347704 0.111302299125794 no 3013 0.114349424938268 967 X1337
SGTC_1872 amphotericin b 148 nM -1.20758135326379 0.110575006772898 no 3014 0.113604167614325 965 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2406 ethylparaben 405.7 µM -1.20762279147803 0.110567225704647 no 3015 0.113596194193698 1000 8434 A possible steroid mimic.
SGTC_3100 9120536 49.47 µM -1.20849204479511 0.110404091965268 no 3016 0.113429026960891 961 16421196
SGTC_2798 7813637 45.45 µM -1.21053978649114 0.110020472306838 no 3017 0.113035916742763 968 956368
SGTC_1006 4099-6547 255 µM -1.2131184498503 0.109538752599856 no 3018 0.112542268523579 989 3146833
SGTC_408 cantharidin 100 µM -1.21820648424895 0.10859270423638 no 3019 0.111572758095212 968 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2914 7968218 45.32 µM -1.22076856337136 0.108118552739966 no 3020 0.111086829808546 948 2977111
SGTC_995 3931-2021 34.6 µM -1.22093695284228 0.108087441999728 no 3021 0.111054945936147 999 730143
SGTC_877 0771-0151 33.1 µM -1.22525008754799 0.10729276585002 no 3022 0.110240503949076 993 6166523
SGTC_249 wiskostatin 11.211 µM -1.23305421906143 0.105865611343206 no 3023 0.108777768131719 949 2775510 A n-wasp and actin depolymerizer.
SGTC_1511 0906-3109 28.5 µM -1.23385104886428 0.105720669391971 no 3024 0.108629206501685 984 2882180
SGTC_1943 st076331 65.2 µM -1.23505953723 0.105501121335268 no 3025 0.108404173484054 984 24208415
SGTC_1569 carminic acid 40.6 µM -1.23563376791551 0.105396915551007 no 3026 0.108297363436028 977 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3269 9137823 49.47 µM -1.23573140441229 0.105379204840214 no 3027 0.108279210049914 939 17682936
SGTC_1297 1068-0111 14.1 µM -1.23711026189475 0.105129317706564 no 3028 0.108023075268884 977 767057
SGTC_3016 9080866 49.47 µM -1.23823172429452 0.10492639413443 no 3029 0.107815075789287 986 17066299
SGTC_742 0kpi-0133 140 µM -1.24057356384906 0.104503563457834 no 3030 0.10738166145345 984 2728852
SGTC_3305 9127027 53.8275 µM -1.24415228919707 0.103859793839877 no 3031 0.106721759740498 976 41905295
SGTC_2984 9022109 38.96 µM -1.24436353878923 0.103821882688918 no 3032 0.106682897895334 1012 6459207
SGTC_2688 kanamycin b 96.69 µM -1.24796935290074 0.103176325458669 no 3033 0.106021140369527 958 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2291 7917025 104.35 µM -1.2483700507748 0.103104767949804 no 3034 0.105947785757449 979 2964612
SGTC_1428 4049-0204 61.7 µM -1.25332938239747 0.102222101734739 no 3035 0.105042929774821 984 X1428
SGTC_1112 tnp00069 1.16933 µM -1.25431510368989 0.102047318959051 no 3036 0.104863748136396 982 145826
SGTC_2910 7948405 25.97 µM -1.25504184007736 0.101918597315874 no 3037 0.104731785839252 942 2971328
SGTC_2282 7944268 200 µM -1.25541069448004 0.101853309988384 no 3038 0.104664854522363 993 2970414
SGTC_2017 5132927 60.65 µM -1.25669070279447 0.101626984293479 no 3039 0.104432828001314 997 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2818 7996756 12.99 µM -1.25889969097415 0.101237261977555 no 3040 0.104033282737918 1004 2241621
SGTC_1996 st072960 66.8 µM -1.26309432666429 0.100500219818432 no 3041 0.103277641324636 970 1719405
SGTC_512 prima-1 270 µM -1.263447123249 0.100438408651208 no 3042 0.103214269037708 988 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_4 0960-0234 25.671 µM -1.26429194957618 0.10029050494853 no 3043 0.103062629012287 964 6821112
SGTC_2123 5259487 200 µM -1.26784071374872 0.0996709592268295 no 3044 0.102427419740455 991 2173474
SGTC_3287 9117173 37.0625 µM -1.26880830744893 0.099502522236899 no 3045 0.102254720734985 941 2789709
SGTC_2803 7707263 71.43 µM -1.26940840289823 0.0993981632655741 no 3046 0.102147720375717 982 2199229
SGTC_2192 5915882 198.485 µM -1.27008476675039 0.0992806368529018 no 3047 0.102027218603778 977 2876149
SGTC_2575 plumbagin 510 nM -1.27188133189025 0.0989689553221824 no 3048 0.101707642814143 972 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2056 5235370 200 µM -1.27537517207989 0.0983648686333668 no 3049 0.101088241076915 996 5511916
SGTC_3104 9120930 49.47 µM -1.27595431189951 0.0982649965245486 no 3050 0.100985835093603 996 17014836
SGTC_3072 9116419 49.47 µM -1.27612399338653 0.0982357491873443 no 3051 0.100955845615751 988 17170162
SGTC_1797 st048695 56.8 µM -1.27925240137515 0.0976976597103171 no 3052 0.100404094159668 973 592262 YIL048W NEO1
SGTC_1807 st050092 58.9 µM -1.27942713780136 0.0976676687076377 no 3053 0.100373341236653 993 5008496
SGTC_260 nsc-65238 3.989 µM -1.28392057100034 0.0968987525359226 no 3054 0.099584874362897 994 3246252
SGTC_2194 5927483 104.545 µM -1.28520126207489 0.0966804167726615 no 3055 0.0993609813648823 979 760979
SGTC_3314 9135860 59.4275 µM -1.2887102771619 0.0960840418814744 no 3056 0.0987494141286122 967 25252478
SGTC_1784 st039334 36.3 µM -1.28913874965817 0.0960114065147033 no 3057 0.0986749271131473 979 3496984
SGTC_2903 5923464 63.88 µM -1.29190375216793 0.0955436494927355 no 3058 0.0981952390851672 997 2876576
SGTC_3293 9120939 62.045 µM -1.29277495181856 0.0953966161858309 no 3059 0.0980444530029647 996 934087
SGTC_135 0933-0004 26.348 µM -1.29388314842577 0.0952098254284613 no 3060 0.0978528930595325 964 21230617 YGL099W LSG1
SGTC_2589 lobaric acid 100 µM -1.29390637976006 0.0952059125827742 no 3061 0.0978488802901589 996 73157 A novel microtubule depolymerizer.
SGTC_1357 1503-1303 39.5 µM -1.29431237607609 0.0951375498785762 no 3062 0.0977787716517552 978 292895
SGTC_1157 4092-0394 27.6 µM -1.29442022863465 0.0951193954661328 no 3063 0.0977601535466397 999 3659885
SGTC_1186 1319-0216 26 µM -1.29564031849357 0.0949142000238636 no 3064 0.0975497158578729 987 4565136
SGTC_579 4491-1009 110 µM -1.29665256565227 0.0947442073649124 no 3065 0.0973753785900069 1010 1271041
SGTC_1806 st050005 60.3 µM -1.29729597285578 0.094636272881116 no 3066 0.0972646847533852 981 5194765
SGTC_1497 4476-2978 41.3 µM -1.30075131137941 0.0940581741694985 no 3067 0.0966717962799131 969 1528379
SGTC_878 0828-0289 13.7 µM -1.30182092421219 0.0938797507836014 no 3068 0.0964888045897056 974 745350 YLR208W SEC13
SGTC_1107 amlodipine 47 µM -1.30324627323396 0.0936423750370869 no 3069 0.0962453484923008 884 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2669 eugenol 100 µM -1.30356724923669 0.0935889813070799 no 3070 0.0961905866720889 980 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2037 5169046 200 µM -1.30395752305968 0.0935240903105703 no 3071 0.0961240327888084 994 5718022
SGTC_3215 9129942 49.47 µM -1.30396525071332 0.0935228057658462 no 3072 0.0961227153242576 1005 17682944
SGTC_1480 1070-0044 41.2 µM -1.30399829853789 0.0935173124719454 no 3073 0.0961170812492983 998 3124987
SGTC_2240 6690706 185.951 µM -1.30503324501895 0.093345401585904 no 3074 0.0959407638468279 991 805876
SGTC_2221 6807166 181.081 µM -1.30613072766512 0.0931633582331718 no 3075 0.095754052528218 984 674925
SGTC_2177 5811945 192 µM -1.30721200777067 0.0929842591640307 no 3076 0.0955703592554516 982 5343475
SGTC_2007 4011539 71.82 µM -1.30750835621295 0.0929352176163246 no 3077 0.0955200594062786 975 45595301
SGTC_3235 9132602 49.47 µM -1.30831349863054 0.0928020742921788 no 3078 0.0953834992576332 989 4912240
SGTC_1783 st039459 87.517 µM -1.31002611038419 0.0925193354322606 no 3079 0.0950935013838586 1015 729761
SGTC_2955 9076254 12.21 µM -1.32041878696612 0.090817241452798 no 3080 0.0933476172580849 989 16459619
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.3215818166251 0.090628217663603 no 3081 0.0931537208059965 995 5282309
SGTC_163 TUB2.036 7.546 µM -1.32180295303699 0.0905923100782988 no 3082 0.093116887376329 967 15992207 YJR013W GPI14
SGTC_1268 0828-0275 2.46 µM -1.32656452247979 0.089821698028864 no 3083 0.0923263890806326 999 745337
SGTC_774 k060-0086 136 µM -1.33007269447254 0.0892570607050166 no 3084 0.0917471605624829 1009 5911235
SGTC_2799 7812892 81.82 µM -1.33238255431793 0.0888867352304108 no 3085 0.0913672559227481 983 20205235
SGTC_1262 0737-0114 49.6 µM -1.33271487894352 0.0888335499540487 no 3086 0.0913126943025731 1003 765919
SGTC_3324 9138759 60.749 µM -1.33524192131032 0.0884298966885891 no 3087 0.0908985902151571 999 45595710
SGTC_2513 baicalein 25.65 µM -1.33839138916525 0.0879287362328235 no 3088 0.090384442200717 1023 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2066 5222451 176 µM -1.33930774053444 0.087783319964936 no 3089 0.0902352549403551 951 2281147
SGTC_2021 4019055 173 µM -1.34006546065166 0.0876632125293833 no 3090 0.0901120319712991 997 44827708 YER133W GLC7
SGTC_1477 0139-0234 16 µM -1.34107567802055 0.0875032721068866 no 3091 0.0899479415576898 1010 620880
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.3411003478867 0.0874993690309472 no 3092 0.0899439371909818 971 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1081 sertraline 6 µM -1.34727314442641 0.0865268352246174 no 3093 0.0889461390367076 993 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3325 9138760 55.175 µM -1.35355632610699 0.0855452321341812 no 3094 0.0879389842303218 975 43844959
SGTC_2888 9058547 12.99 µM -1.35557809792422 0.08523115666171 no 3095 0.0876167221958609 979 16476514
SGTC_2772 vinpocetine 57.06 µM -1.35596913229533 0.0851705106211909 no 3096 0.0875544947666781 1004 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2759 disulfiram 3.38 µM -1.35608312867096 0.0851528368605533 no 3097 0.0875363601127558 973 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_232 clozapine 119 µM -1.35883521325247 0.0847269930291869 no 3098 0.0870994060956866 1003 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2860 9025725 38.96 µM -1.3595278253258 0.0846200736553981 no 3099 0.0869896956759988 1021 40546248
SGTC_3181 9108277 49.47 µM -1.36711399000167 0.083455604975253 no 3100 0.0857947894288952 1010 17097298
SGTC_1347 1493-0251 600 nM -1.37049019539942 0.0829412503703039 no 3101 0.0852669669612443 946 3986378
SGTC_1993 st073995 70.8 µM -1.37450163130895 0.0823332245158065 no 3102 0.0846430020831833 1002 3098394
SGTC_70 0141-0289 43.283 µM -1.37631530231207 0.0820594251305709 no 3103 0.0843620186776547 974 352408
SGTC_895 0964-0006 13.7 µM -1.37765519239091 0.0818575907004634 no 3104 0.0841548858624254 1011 6738897
SGTC_2975 9084847 53.72 µM -1.38467951766434 0.0808055989611843 no 3105 0.083075242393168 1004 27211724
SGTC_1349 flufenamic acid 69 µM -1.39246710706543 0.0796512651810864 no 3106 0.0818904977571379 1007 3371 A non-steroidal anti-inflammatory.
SGTC_1884 5633444 25 µM -1.40400086240416 0.0779646281982044 no 3107 0.0801592963799131 997 5724239
SGTC_1025 k007-0731 70 µM -1.40468026375567 0.0778661277517356 no 3108 0.0800581885751052 1016 6256118
SGTC_2880 9042983 58.44 µM -1.40549368591691 0.0777483210615881 no 3109 0.0799372627879038 1022 6464714
SGTC_2380 9035439 200 µM -1.40584070791223 0.0776981035858531 no 3110 0.0798857155049294 998 6462575
SGTC_1676 st018489 23.4 µM -1.40679257217161 0.0775604859188585 no 3111 0.0797444528868436 997 3696235
SGTC_2605 digitonin 300 nM -1.41224487228815 0.0767757727932102 no 3112 0.078938936123729 1008 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.41621395179291 0.0762083370168857 no 3113 0.0783564361197336 1038 91467 include heat shock
SGTC_3015 9080845 49.47 µM -1.41787292491729 0.075972111551864 no 3114 0.0781139342017735 1018 5296973
SGTC_2251 lansoprazole 556 µM -1.42023024125982 0.0756374067106033 no 3115 0.0777703311362806 1020 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2092 5303694 80.6725 µM -1.42083849613874 0.0755512259165877 no 3116 0.0776818582142854 1013 1963699
SGTC_1102 cgs 12066b 26.1 µM -1.42248189361107 0.0753187547750411 no 3117 0.0774432020830907 1012 6438352 A 5-HT1B full agonist.
SGTC_1276 0871-0068 94.2 µM -1.42406473200776 0.075095366063027 no 3118 0.077213867251963 1014 3414906
SGTC_671 0560-0003 407 µM -1.42966344913791 0.0743092625091618 no 3119 0.0764068177396823 1021 3238678
SGTC_2690 usnic acid 100 µM -1.43214100899962 0.0739634059704674 no 3120 0.0760517350936243 1030 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2909 7941780 10.49 µM -1.43296069225501 0.0738492529527203 no 3121 0.0759345354872961 984 1243215
SGTC_2851 9015922 71.43 µM -1.43382160550601 0.0737295030722167 no 3122 0.0758115888827063 1001 2996893
SGTC_2183 6420625 130.508 µM -1.4387422063722 0.073047912299661 no 3123 0.0751117881606464 1005 2897619
SGTC_2713 st079149 53.4 µM -1.44430463415725 0.0722832354235202 no 3124 0.0743266514040224 1015 3103253
SGTC_1457 k015-0032 57.3 µM -1.44468671626239 0.07223093592008 no 3125 0.0742729513978753 1014 4302660
SGTC_251 melphalan 456.522 µM -1.44590981406864 0.0720637129562161 no 3126 0.0741012494518147 1031 460612 A DNA alkylator.
SGTC_1453 4237-0541 195 µM -1.44871041608516 0.0716819302646683 no 3127 0.0737092351909426 984 739892
SGTC_2244 6635614 200 µM -1.45041133943914 0.071450816091025 no 3128 0.0734719234208259 1029 836499
SGTC_1653 st012112 65 µM -1.45518223252358 0.0708056189736237 no 3129 0.0728094091720496 1014 720429
SGTC_295 k015-0027 31 µM -1.45545981060508 0.0707682186339908 no 3130 0.072771004308717 1020 3887424
SGTC_2097 5376186 200 µM -1.4558143299575 0.0707204734505833 no 3131 0.0727219766418994 1017 742755
SGTC_1494 4358-1428 177 µM -1.4580061558773 0.0704258369128734 no 3132 0.0724194231204262 1004 1564571
SGTC_2718 lomofungin 53.02 µM -1.45822919316532 0.0703959080727358 no 3133 0.0723886898172354 1017 5351222 A RNA synthesis inhibitor.
SGTC_1618 st003135 44.5 µM -1.45996764057387 0.070162965037822 no 3134 0.0721494837912884 1035 1270615
SGTC_1021 4476-0760 85.3 µM -1.46027449516612 0.0701219097293397 no 3135 0.0721073243480035 1029 746768
SGTC_221 trifluoperazine 10.304 µM -1.46239335780524 0.0698389227671568 no 3136 0.0718167242787115 1010 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_114 0364-0001 490.298 µM -1.46334530083513 0.0697120714954265 no 3137 0.0716864589496875 1031 4003655
SGTC_485 niflumic acid 177 µM -1.46507869493807 0.0694815434907309 no 3138 0.0714497242988204 1045 4488 A COX2 inhibitor.
SGTC_757 1066-0008 322 µM -1.46525152025018 0.069458591283261 no 3139 0.0714261539763141 1002 6842497
SGTC_2443 5493264 126.67 µM -1.46710136738748 0.0692132864082152 no 3140 0.0711742411161583 1033 5340055
SGTC_2124 5246320 200 µM -1.47764435895531 0.0678279229362852 no 3141 0.069751497282443 1010 579342
SGTC_2777 climbazole 1.536 µM -1.47876843337771 0.0676814904850592 no 3142 0.0696011076170937 1030 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2459 5811157 9.22 µM -1.48096868369423 0.0673955723021609 no 3143 0.0693074593605755 1034 2870684 YBR192W RIM2
SGTC_2423 st077119 87.2 µM -1.48136353731561 0.0673443607999881 no 3144 0.069254862834755 1010 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_759 3486-0358 89.3 µM -1.48394829775214 0.0670098666264786 no 3145 0.0689113186880482 1039 875103
SGTC_1447 4239-0816 81.9 µM -1.4843200968664 0.0669618579536615 no 3146 0.0688620106057437 1012 1341554
SGTC_647 0140-0236 81 µM -1.49240656019849 0.0659242600236645 no 3147 0.0677962981489071 1038 990837
SGTC_621 3584-0052 32.1 µM -1.49455609412923 0.0656505539689074 no 3148 0.0675151660146132 1019 2273927
SGTC_3341 9147222 25.867 µM -1.49504596524924 0.0655883007791683 no 3149 0.0674512232259714 1007 1939759
SGTC_493 zm226600 134 µM -1.50087499618283 0.064851051377545 no 3150 0.0666939482197438 1026 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2930 9013230 14.89 µM -1.50671025895556 0.0641194744216176 no 3151 0.0659424703950996 988 2995857
SGTC_896 0964-0007 44.5 µM -1.50950591525359 0.0637712590877811 no 3152 0.0655847723968436 1003 6756758
SGTC_2158 5657123 3.6195 µM -1.51130192552309 0.0635483327402679 no 3153 0.0653557718012327 1038 2858827
SGTC_2890 9046729 58.44 µM -1.51887172901016 0.0626154038230393 no 3154 0.0643973932000699 1027 903329
SGTC_961 1252-1571 372 µM -1.51891641687822 0.0626099282053293 no 3155 0.0643917680708451 1029 6813498
SGTC_1045 1348-1485 165 µM -1.5216676573223 0.0622735361913393 no 3156 0.0640461877473903 1025 6810614
SGTC_2055 5235184 200 µM -1.52934117675423 0.0613427478332335 no 3157 0.0630899433696204 1014 2836034
SGTC_77 0828-0286 12.516 µM -1.54062992355305 0.0599932364753571 no 3158 0.0617034404120034 1012 745345
SGTC_3346 9158254 43.5805 µM -1.54487193700234 0.0594921772495898 no 3159 0.0611886213048386 1025 17639500
SGTC_96 0929-0093 37.281 µM -1.54939829148936 0.0589611557017037 no 3160 0.0606430021187095 1026 6991579
SGTC_1238 0333-0287 48.8 µM -1.55327542737238 0.0585092621890266 no 3161 0.0601786740682696 1019 7226
SGTC_2139 5578692 56.4705 µM -1.56042545713501 0.0576830381187893 no 3162 0.0593296864110979 985 650991 YMR113W FOL3
SGTC_1163 k060-0048 49.9 µM -1.5624579292407 0.0574498575727312 no 3163 0.0590900746980471 1047 6809982
SGTC_541 4513-1321 94 µM -1.56412297324012 0.0572593842785292 no 3164 0.0588943459143604 1013 747515
SGTC_1747 st037496 66.6 µM -1.56518686231797 0.05713794076658 no 3165 0.0587695505334194 1031 723305
SGTC_1411 3909-8223 150 µM -1.56548908233709 0.0571034791914272 no 3166 0.058734137664575 1042 X1411
SGTC_2721 ifenprodil 61.44 µM -1.57719591703028 0.055781119485041 no 3167 0.0573752260942629 1027 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_922 1866-0035 480 µM -1.57736398014987 0.0557623131588717 no 3168 0.0573558992490884 1001 3156169
SGTC_443 clozapine 122 µM -1.57868381241255 0.0556147973068428 no 3169 0.0572042998059288 1052 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_419 nsc-638432 893 µM -1.58374265348799 0.0550522286477646 no 3170 0.0566261470472762 1030 368090
SGTC_44 0929-0055 61.211 µM -1.58424197760843 0.0549969459592628 no 3171 0.0565693320072733 995 1379590
SGTC_3236 9132701 49.47 µM -1.59352817270631 0.0539767973840138 no 3172 0.0555208766918599 1049 24282524
SGTC_1888 azatryptophan 97.5 µM -1.59624478608932 0.0536812091460346 no 3173 0.0552170760192511 1030 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1547 harmine 94.2 µM -1.60470085926358 0.0527693245636161 no 3174 0.0542798263787058 1009 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3084 9116877 49.47 µM -1.60615550956683 0.0526137043957566 no 3175 0.054119872968355 1028 27241325
SGTC_43 0570-0105 72.5 µM -1.61569429219729 0.0516022403987163 no 3176 0.0530802128335444 1029 1114046 YDL195W SEC31
SGTC_1234 0326-0494 15.5 µM -1.61605189308135 0.0515646242518338 no 3177 0.0530415470112443 1036 1547813
SGTC_612 0302-0167 22.4 µM -1.61656660230864 0.0515105201096684 no 3178 0.0529859329635064 1038 235821
SGTC_237 nikkomycin 200 µM -1.62135002637354 0.0510098626012044 no 3179 0.0524712959103419 1048 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2181 6316240 54.2555 µM -1.62305256862706 0.0508326033159264 no 3180 0.0522890838828418 1041 12779990
SGTC_3118 9124250 49.47 µM -1.62356279446458 0.0507795770418388 no 3181 0.0522345756900724 1020 1504786
SGTC_908 3448-7491 47.7 µM -1.6331000898598 0.0497964772261133 no 3182 0.0512239738579831 988 1203031
SGTC_2361 9034121 116 µM -1.63465593515221 0.0496375515460672 no 3183 0.0510605973783394 1055 6496917
SGTC_1781 st038725 66.3 µM -1.63655549857055 0.0494440649437756 no 3184 0.0508616902454167 1043 4270275 YIL048W NEO1
SGTC_2602 kawain 100 µM -1.64230883130632 0.0488617104257254 no 3185 0.0502630089144011 1024 5369129
SGTC_3170 9103054 49.47 µM -1.64406622142969 0.0486849236615003 no 3186 0.050081262177008 1012 16432970
SGTC_2739 tacrine 100.86 µM -1.66161911952263 0.0469470913113646 no 3187 0.0482945836533109 958 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.66168068680101 0.0469410845441748 no 3188 0.0482884077707264 1041 115019
SGTC_1631 benzylvanillin 81.9 µM -1.66537000941742 0.0465822620723881 no 3189 0.0479194794676391 1015 75506
SGTC_795 0685-0265 78 µM -1.66634645301611 0.0464876627434098 no 3190 0.0478222147115973 1035 302754
SGTC_173 1273-0061 2.693 µM -1.67207407413857 0.0459358631313769 no 3191 0.04725485811849 1003 2847414 YPL266W DIM1
SGTC_2207 7258803 200 µM -1.67746173788934 0.0454216301748662 no 3192 0.0467261127300537 1043 3666799
SGTC_624 k048-0052 28 µM -1.6838378025892 0.0448190506404276 no 3193 0.0461065096372056 1049 6835531
SGTC_2129 girgensonine 121.053 µM -1.69322986066349 0.043943180994425 no 3194 0.0452058614197477 1038 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2387 9077560 195.08 µM -1.69545235821698 0.043737951752756 no 3195 0.0449948203367126 1029 5303272
SGTC_1623 st003709 20.3 µM -1.70188545127905 0.0431482647615708 no 3196 0.0443884217936569 1031 16192618
SGTC_2345 9052315 157.45 µM -1.70228190048822 0.0431121354879327 no 3197 0.0443512680330271 1032 6469265
SGTC_2225 6654152 15.4 µM -1.70528690594928 0.04283907679697 no 3198 0.044070464234178 1024 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1470 k295-0292 231 µM -1.70661929588121 0.042718453349983 no 3199 0.0439464181470697 1064 5045612
SGTC_1375 2910-0797 186 µM -1.70878103873672 0.0425233314605172 no 3200 0.0437457581413347 1044 742508
SGTC_2756 carbadox 75.1 µM -1.71624583764658 0.0418550836278694 no 3201 0.0430585284417332 1014 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2698 st077697 67.5 µM -1.7178048018416 0.0417166043573086 no 3202 0.0429161126924284 1050 3154499
SGTC_768 0384-0033 77.3 µM -1.7235649984908 0.0412081545589855 no 3203 0.0423932008919626 1016 3965305 YMR134W ERG29
SGTC_634 1611-4317 11.2 µM -1.72573458325352 0.0410179537311015 no 3204 0.0421975866673156 1053 2843522
SGTC_1665 st014639 11.4 µM -1.73009448071158 0.0406378880088736 no 3205 0.0418066980935187 1053 981133 YIL048W NEO1
SGTC_2108 5365811 200 µM -1.73762151286611 0.0399884636938373 no 3206 0.0411387633140033 1037 780283
SGTC_405 ebelactone b 50 µM -1.74650940071653 0.0392325120317266 no 3207 0.0403612374963968 1047 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2030 5175110 200 µM -1.76384866235008 0.0377912196704278 no 3208 0.0388787310457381 1053 2831986
SGTC_1057 3448-5381 134 µM -1.7655225017358 0.0376544023744579 no 3209 0.0387379959440572 993 5497911
SGTC_2647 atorvastatin 60.16 µM -1.76752773310841 0.037491030228536 no 3210 0.0385699443469761 1036 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_620 0109-0052 432 µM -1.77710670498567 0.0367185721246714 no 3211 0.0377753426049957 1049 493037
SGTC_903 1134-0042 114 µM -1.77959382106212 0.0365201514548401 no 3212 0.0375712290846891 1042 701009
SGTC_2468 5987765 72.9 µM -1.78281253520913 0.0362646675820143 no 3213 0.0373084122747466 1054 26772094
SGTC_2506 ethyl hematommate 54.16 µM -1.78346499787986 0.0362130574455027 no 3214 0.0372553204210007 1047 3940691 An allergen.
SGTC_2654 protoveratrine a 100 µM -1.7884450492101 0.0358211109249871 no 3215 0.0368521168660035 1064 5702278 A heart drug and vasodilator.
SGTC_282 k297-0036 65.7 µM -1.78852656544088 0.0358147243563703 no 3216 0.0368455468065808 1047 5061378
SGTC_2727 riluzole 51.77 µM -1.80210016174997 0.0347642111216477 no 3217 0.0357648241387592 1065 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2292 7671323 168.05 µM -1.80582967090071 0.0344800427284928 no 3218 0.0354724746480361 1056 937504
SGTC_1808 st050063 61.5 µM -1.81166454165889 0.0340392878517016 no 3219 0.0350190228219455 1046 4011993
SGTC_3351 9150312 21.596 µM -1.81632698591537 0.033690435222409 no 3220 0.0346601140158618 1062 4904905
SGTC_3030 9087619 49.47 µM -1.82319325341721 0.0331820499135112 no 3221 0.0341370632664292 1045 25236973
SGTC_74 000s-0487 160.283 µM -1.82631992137361 0.0329526512831569 no 3222 0.0339010430934766 1033 677548
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.82779898772545 0.0328445908104147 no 3223 0.0337898626076743 1055 551469
SGTC_1745 st081495 74 µM -1.83213685415827 0.0325293501810284 no 3224 0.0334655169105626 1031 13842402 YBL026W LSM2
SGTC_3278 9139605 49.47 µM -1.83490556712172 0.0323294507231639 no 3225 0.0332598413325626 1047 7958859
SGTC_2724 maprotiline 69.64 µM -1.83585532013528 0.0322611130539946 no 3226 0.0331895286046048 1028 4011 A tricyclic antidepressant.
SGTC_2968 9090663 33.37 µM -1.83775485118985 0.0321247935670932 no 3227 0.0330492686269728 1025 25236811
SGTC_2531 methyl deoxycholate 70.07 µM -1.8378391632253 0.0321187539686361 no 3228 0.0330430544258792 1051 16667744 Haematoxylin.
SGTC_464 bw-b 70c 158 µM -1.84504354865713 0.0316061276052061 no 3229 0.0325156019801145 1059 5353454
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.8450585364282 0.0316050682438247 no 3230 0.0325145119673588 1045 688664
SGTC_1224 0823-0416 294 µM -1.84694063451052 0.0314722713496331 no 3231 0.0323778723373601 1054 3598164
SGTC_2521 angolensin 13.4 µM -1.84799841854734 0.0313978390216246 no 3232 0.0323012858067133 1051 821428 A flavenoid.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.84934392041294 0.0313033714336867 no 3233 0.0322040837899896 1056 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1325 1431-0015 227 µM -1.85246496720727 0.0310851476972839 no 3234 0.0319795418383183 1060 1103340
SGTC_1113 artemisinin 1.17947 µM -1.85298735038742 0.0310487458930506 no 3235 0.0319420858812378 1023 2240 An anti-malaria and mitochondrial poison.
SGTC_1229 0139-0193 12.2 µM -1.86779723185854 0.0300313178073405 no 3236 0.0308951697297081 1043 3090752
SGTC_2749 bexarotene 57.39 µM -1.87905687167432 0.0292764215352939 no 3237 0.0301183640890573 1042 82146 An retinoic acid receptor inhibitor.
SGTC_2444 5485484 36.41 µM -1.88452282640617 0.0289156812515309 no 3238 0.0297471450846375 1067 6790631
SGTC_190 3970-0790 3.722 µM -1.8908406283197 0.0285033319604686 no 3239 0.0293228109466596 1065 2832352
SGTC_63 0099-0242 26.702 µM -1.89461281716815 0.0282594700334596 no 3240 0.0290718577428465 1059 3898502 YLR359W ADE13
SGTC_2164 5685496 200 µM -1.89661616372322 0.0281306666628945 no 3241 0.0289393078544207 1058 759046
SGTC_3024 9090631 49.47 µM -1.90211276374125 0.027779775897104 no 3242 0.0285782070818208 1045 25236383
SGTC_69 0096-0274 206.684 µM -1.90442778061162 0.0276330856735915 no 3243 0.0284272470001861 1055 6741392
SGTC_766 1391-0721 126 µM -1.93392519277082 0.0258198550652123 no 3244 0.0265611630688347 1066 1020919 YIL115C NUP159
SGTC_1423 4048-0112 5.59 µM -1.93992832997179 0.0254633009952195 no 3245 0.0261942002845984 1065 X1423
SGTC_1026 k007-1105 30.6 µM -1.96419500458135 0.0240637454428805 no 3246 0.0247537409554753 1059 7066794
SGTC_2339 9000433 200 µM -1.9741932725692 0.0235062048251105 no 3247 0.0241798853357347 1055 2988954
SGTC_467 ro 31-8220 72.8 µM -1.97446403592152 0.0234912584699432 no 3248 0.0241645014611043 1052 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_880 0833-0487 87.2 µM -1.97688868308444 0.0233577720156231 no 3249 0.0240271071558876 1069 76075
SGTC_3347 9188721 44.724 µM -1.98045511561967 0.0231625861315338 no 3250 0.0238262060343431 1072 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1672 st016598 6.51 µM -1.98631944802189 0.0228446253760757 no 3251 0.0234989322625893 1059 4665860 YNL267W PIK1
SGTC_1811 st050069 61.5 µM -1.98632015143628 0.0228445874590543 no 3252 0.0234988932347797 1072 3877702
SGTC_2220 6782180 200 µM -1.99917260263469 0.0221605810405488 no 3253 0.022794840908397 1061 833803
SGTC_1164 k060-0068 93.7 µM -2.00707436477214 0.0217486911992835 no 3254 0.0223708726765706 1071 5963676
SGTC_2063 5246145 200 µM -2.00809463328212 0.0216959827752435 no 3255 0.0223166182299412 1066 711240
SGTC_2373 9071805 200 µM -2.01552359037673 0.0213154374888296 no 3256 0.021924908419209 1075 10149009
SGTC_3124 9127567 49.47 µM -2.02463866363385 0.0208562471770854 no 3257 0.0214522405436675 1049 17592030
SGTC_2276 7947513 42.08 µM -2.04022126389551 0.0200906374131968 no 3258 0.020664146391237 1072 2105100
SGTC_2708 st078559 56 µM -2.04139741191936 0.0200338306955224 no 3259 0.0206056707508706 1047 17250902
SGTC_2625 euphol 100 µM -2.04726830586229 0.0197523060689769 no 3260 0.020315874003805 1054 6708538 A triterpene alcohol.
SGTC_688 0527-0193 473 µM -2.06009279896858 0.0191490007728287 no 3261 0.0196948350820908 1079 4007154
SGTC_1272 0839-0021 27 µM -2.06268260556492 0.0190290882297241 no 3262 0.0195713968082697 1076 5027250
SGTC_372 0155-0182 15.9 µM -2.06909462853231 0.0187349451527269 no 3263 0.019268603848278 942 771486
SGTC_2639 lactacystin 53 µM -2.0735387973327 0.0185333527611286 no 3264 0.0190610821621125 1050 3870 A proteasome inhibitor.
SGTC_2088 5278280 127.392 µM -2.07526945072843 0.0184553496170699 no 3265 0.0189807845449994 1076 791502
SGTC_289 k017-0060 526 µM -2.08490493805063 0.0180261571095154 no 3266 0.0185389651783322 1077 5512909
SGTC_2825 7998094 58.44 µM -2.09631529465244 0.0175289396267058 no 3267 0.0180271154317003 1075 2987815
SGTC_2473 5854593 8.94 µM -2.0982138263385 0.0174473558395223 no 3268 0.0179431303882837 1071 2872951
SGTC_3179 9107801 49.47 µM -2.09891399826199 0.0174173499644772 no 3269 0.0179122413244754 1066 4818259
SGTC_192 3455-0609 60.9 µM -2.10258081112303 0.0172609273617742 no 3270 0.0177512143839753 1074 3769639
SGTC_3279 9140807 49.47 µM -2.10540259252395 0.0171413715315957 no 3271 0.0176281391619079 1075 45595718
SGTC_2382 9035899 200 µM -2.10668772088901 0.0170871569960032 no 3272 0.0175723286359134 1072 6462679
SGTC_650 1328-0195 38 µM -2.10724580877548 0.0170636591313774 no 3273 0.0175481390189505 1078 2780821
SGTC_2725 haloperidol 53.21 µM -2.10786828872415 0.0170374826769039 no 3274 0.0175211919486608 1063 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_946 3434-1334 87.4 µM -2.11441367577023 0.0167643086038783 no 3275 0.0172399753104045 1058 4047976
SGTC_2193 5925765 200 µM -2.11564236245913 0.016713448791724 no 3276 0.0171876180263126 1064 877370
SGTC_2243 6634756 200 µM -2.12831409688535 0.0161965757095189 no 3277 0.0166555250430019 1059 885676
SGTC_596 1155-0152 116 µM -2.15087050766103 0.01531036192597 no 3278 0.0157432109792952 1071 280313
SGTC_2385 9074692 200 µM -2.16114993071494 0.0149205133135982 no 3279 0.0153418798235558 1074 17046906
SGTC_3083 9117465 49.47 µM -2.17343798816432 0.0144657132000424 no 3280 0.0148736841546224 1072 16420915
SGTC_46 0329-0187a 2.197 µM -2.18972044639217 0.0138814939043197 no 3281 0.0142722586505401 1060 46494817
SGTC_3214 9129694 49.47 µM -2.19070418939732 0.0138468581275241 no 3282 0.0142366028689381 1073 17158655
SGTC_2249 haloperidol 116.36 µM -2.19308583118284 0.0137633133937925 no 3283 0.014150597832948 1049 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3238 9133470 49.47 µM -2.19403364255746 0.0137301866187456 no 3284 0.0141164955285246 1066 3534688
SGTC_127 0180-0333 59.125 µM -2.20922885552497 0.013208418050945 no 3285 0.0135793633961845 1035 771601
SGTC_1015 4130-4525 82 µM -2.21045156871114 0.0131671876403834 no 3286 0.0135369191050727 1073 1363237
SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.216164851886 0.0129760039370036 no 3287 0.0133401070424251 1071 6708630 An antioxidant.
SGTC_1554 st069299 38.7 µM -2.21712098572469 0.0129442443727298 no 3288 0.0133074125510904 1070 24207999
SGTC_531 3788-1495 174 µM -2.25079886645349 0.0118676509526014 no 3289 0.012199139688828 1073 2896655
SGTC_2486 5283202 22.39 µM -2.25636778465963 0.0116973241170644 no 3290 0.0120238037243084 1067 1377751
SGTC_525 k781-2675 26.7 µM -2.26741396091419 0.0113657437334404 no 3291 0.0116824747180179 1053 3651118 YDL195W SEC31
SGTC_1153 4055-0057 267 µM -2.27163605740901 0.0112411807740093 no 3292 0.0115542505878577 1071 882706
SGTC_2845 9003024 42.97 µM -2.28010778354748 0.010994817840195 no 3293 0.0113006483549098 1074 2990173
SGTC_1369 1866-0067 208 µM -2.28640723445364 0.0108146837674163 no 3294 0.0111152227485236 1064 3531355
SGTC_652 0437-0092 114 µM -2.3003764559995 0.0104243721004592 no 3295 0.0107134507539447 1081 3091274
SGTC_3292 9120825 59.784 µM -2.30535443539622 0.0102882809855614 no 3296 0.0105733655799303 1068 24824900
SGTC_2552 juarezic acid 87.02 µM -2.31698037896729 0.00997646311742649 no 3297 0.0102524003114606 1068 1549512
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.31760164849179 0.00996003484816244 no 3298 0.0102354902682099 1070 4000243
SGTC_1728 st035614 33.7865 µM -2.33792207734615 0.00943556132518995 no 3299 0.00969564538498531 1071 15945546
SGTC_367 0335-0881 7.1 µM -2.3379242958474 0.00943550540994836 no 3300 0.00969558783198964 1073 23828853
SGTC_623 k072-0108 16.9 µM -2.3469535986326 0.00921031730496158 no 3301 0.0094638058885168 1074 5382803
SGTC_1368 1852-0141 284 µM -2.35757575004723 0.00895143779510896 no 3302 0.0091973509655584 1072 2838987
SGTC_1044 1222-0021 1.78 µM -2.38452904678436 0.00832295196128618 no 3303 0.00855049896532213 1039 4306703
SGTC_3068 9116768 49.47 µM -2.39490899640464 0.00809145355375218 no 3304 0.0083122454215267 1072 41904888
SGTC_2868 9035608 32.47 µM -2.42415227492145 0.00746941359623764 no 3305 0.00767208501215736 1080 6462614
SGTC_2310 7668677 200 µM -2.42628520253392 0.00742573768634957 no 3306 0.00762713863287613 1078 2197143
SGTC_2705 st078069 42.8 µM -2.43542114813539 0.00724119723405115 no 3307 0.0074372330651671 1083 1530061
SGTC_330 1488-0319 80.1 µM -2.45088520413584 0.00693803681063042 no 3308 0.00712526965739451 1076 6846614
SGTC_1377 2944-0135 198 µM -2.46460999917309 0.00667841711366751 no 3309 0.00685812274950728 1068 1894137
SGTC_1814 st052110 31.539 µM -2.52978083790254 0.0055592865817625 no 3310 0.0057066896801895 1085 674163
SGTC_2828 7998861 71.43 µM -2.56028497840231 0.0050952256690548 no 3311 0.00522931806331374 1081 2988188
SGTC_3114 9122766 49.47 µM -2.57755790995402 0.0048480337221844 no 3312 0.00497506037225625 1079 17176985
SGTC_2854 9024559 71.43 µM -2.57959125864878 0.00481964943359589 no 3313 0.00494586593130333 1070 3163529
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.58212648156342 0.00478446686504406 no 3314 0.00490967952340047 1079 688788
SGTC_432 NS 1619 61.3 µM -2.59905148533393 0.00455540083463514 no 3315 0.0046740875668024 1079 4552 A K+/calcium channel activator.
SGTC_2790 5423970 71.43 µM -2.6214055022369 0.00426788040864811 no 3316 0.00437840176359957 1077 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2929 9013348 24.6 µM -2.63037646055887 0.00415713358653976 no 3317 0.00426451811536528 1078 2995952
SGTC_287 k060-0039 29.6 µM -2.64049113155466 0.00403535697693168 no 3318 0.0041392979655289 1090 5861974
SGTC_3101 9120531 49.47 µM -2.64401642337793 0.00399367042385497 no 3319 0.0040964340410712 1083 24824904
SGTC_3035 9091303 49.47 µM -2.64494719715935 0.00398272857368466 no 3320 0.00408518327834809 1090 25237002
SGTC_2964 9083345 53.42 µM -2.64769007881149 0.00395064017558273 no 3321 0.00405218925196764 1072 17741579
SGTC_3142 9086498 49.47 µM -2.66005706204951 0.0038088187784688 no 3322 0.00390637069760176 1062 25236367
SGTC_2161 5662504 8.5105 µM -2.67248341901876 0.00367093025289262 no 3323 0.0037646047656429 1070 2859334
SGTC_2978 9011784 42.97 µM -2.70020598995916 0.00337932192138703 no 3324 0.00346482779195093 1069 2994934
SGTC_528 3492-0019 172 µM -2.70319759750183 0.00334913254229426 no 3325 0.0034337953340354 1084 2869262
SGTC_2675 theaflavin digallate 100 µM -2.72415270980016 0.00314437593604979 no 3326 0.00322333453653121 1089 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_503 tyrphostin 8 294 µM -2.73684621584468 0.00302589458040628 no 3327 0.00310156417913211 1089 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_642 0335-0876 158 µM -2.75881655175647 0.00283029431955909 no 3328 0.00290055451138773 1088 6812350
SGTC_1952 st077036 64.1 µM -2.78109316307703 0.00264368422262359 no 3329 0.00270880937783303 1076 2937007
SGTC_2977 9011197 71.43 µM -2.82128938433425 0.00233486210153861 no 3330 0.00239155169791955 1081 2704722
SGTC_2902 5787006 60.46 µM -2.84496314329089 0.00216864233716067 no 3331 0.0022208281064109 1080 591003
SGTC_1803 st050068 52.4 µM -2.85271775061168 0.00211657437514335 no 3332 0.00216735516335326 1083 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2829 7992743 58.44 µM -2.8696553083786 0.00200676974371826 no 3333 0.00205459738366186 1086 16462845
SGTC_365 0121-0052 13.6 µM -2.87772867344356 0.00195627320949033 no 3334 0.00200274743172228 1076 3101739
SGTC_381 3461-2219 42.7 µM -2.90949104966938 0.00176861625334951 no 3335 0.00181008876210614 1090 2883159
SGTC_452 diindolylmethane 8 µM -2.91187999050563 0.00175518681893421 no 3336 0.00179630317647028 1090 3071 Inhibits expression of several cancer promoting factors.
SGTC_1373 2887-0003 58.5 µM -2.98357986112091 0.00139287607657987 no 3337 0.001424488380828 1092 776948
SGTC_2497 7-hydroxyflavone 100 µM -2.9951730635232 0.00134117132188567 no 3338 0.00137144583731631 1087 5281894
SGTC_500 h-89 112 µM -3.01050498238464 0.00127548567643219 no 3339 0.00130406834482115 1090 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2460 5552655 174.22 µM -3.01833319386882 0.0012430947101163 no 3340 0.00127084641348872 1089 5401989
SGTC_2936 9038235 15.59 µM -3.05462996909397 0.00110251885327568 no 3341 0.00112669177273412 1078 4749415
SGTC_645 0845-0943 5.41 µM -3.06340606867856 0.00107079256057378 no 3342 0.00109416446362588 1089 1885106
SGTC_1479 0549-0158 134 µM -3.0743717194535 0.0010323277712184 no 3343 0.00105473209057761 1094 5440202
SGTC_2172 5754775 163.918 µM -3.22098196962959 0.000626275092848124 yes 3344 0.000638760924993949 1088 2263357
SGTC_2906 7926292 26.41 µM -3.24883212964004 0.000568273310672125 yes 3345 0.000579399209755878 1090 2966319
SGTC_1137 ixabepilone 100 µM -3.28935089231533 0.000492710430096433 yes 3346 0.000502093737411537 1088 154225 A novel microtubule stabilizer.
SGTC_1942 st076330 65.2 µM -3.35876763718066 0.000384497497906715 yes 3347 0.000391454339963835 1089 24208414
SGTC_1752 st044819 83.042 µM -3.402832746492 0.000327731233320543 yes 3348 0.000333455461352252 1090 441209 YML126C ERG13
SGTC_2483 5729050 27.16 µM -3.60294252171443 0.000155086031751288 yes 3349 0.000157317561036312 1093 2865180
SGTC_2834 9001755 58.44 µM -3.60469265365509 0.00015404906818128 yes 3350 0.00015626127517277 1083 2989575
SGTC_1082 camptothecin 424.86 nM -3.74006090907564 9.08913768311219e-05 yes 3351 9.1987834199711e-05 1078 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3103 9120822 49.47 µM -3.83759426303537 6.14893154909811e-05 yes 3352 6.21227734808174e-05 1092 17141819
SGTC_772 k072-0172 35.3 µM -3.89973090425438 4.77140420745612e-05 yes 3353 4.81498294199984e-05 1092 5861980
SGTC_1409 3909-8004 61.9 µM -4.00719559822005 3.05076067655822e-05 yes 3354 3.0721987979072e-05 1094 2119279
SGTC_2844 9010103 25.97 µM -4.56648747465635 2.49394072925894e-06 yes 3355 2.47982329083473e-06 1093 2480525
SGTC_1944 st076371 56.9 µM -4.94421986929705 3.88399629205555e-07 yes 3356 3.82246918032286e-07 1095 24208455