SGTCid condition conc unit ASF1|YJL115W.score ASF1|YJL115W.strain.pval ASF1|YJL115W.strain.significant ASF1|YJL115W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 6.14914269527353 1.51729027550769e-09 yes 1 3.89514346952127e-10 6 6708760 SGTC_2751 anetholtrithion 17.25 µM 5.28902768397246 1.55341263285533e-07 yes 2 6.14841402831432e-08 9 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2407 paclitaxel 400 µM 5.22876688176187 2.09740220494234e-07 yes 3 8.53221844227659e-08 13 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2123 5259487 200 µM 4.69133216482188 2.65710078073357e-06 yes 4 1.35715941307882e-06 10 2173474 SGTC_2934 9036370 36.88 µM 4.28701453588706 1.52381709237549e-05 yes 5 9.05452238570382e-06 23 6462800 SGTC_2110 5483698 200 µM 4.27794650758671 1.58215275320916e-05 yes 6 9.43126663640254e-06 15 2848765 YHR062C RPP1 SGTC_2421 5690543 90.72 µM 3.973501133202 5.36228158809339e-05 yes 7 3.54119105405797e-05 18 3397993 SGTC_1944 st076371 56.9 µM 3.86472034034847 8.13688966407655e-05 yes 8 5.56082764747472e-05 22 24208455 SGTC_2662 daunorubicin 22.37 µM 3.8586440900837 8.32618818270664e-05 yes 9 5.70089191087823e-05 16 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2814 7977482 42.97 µM 3.74638990969344 0.000126625333329771 yes 10 8.96988398488035e-05 59 6456762 SGTC_1836 st055642 81 µM 3.71223214389588 0.00014355067066947 yes 11 0.000102719713451099 20 8571 SGTC_417 st075190 100 µM 3.51008588186686 0.000295592662689458 yes 12 0.000223980991688846 21 222757 SGTC_2546 rhodinyl acetate 100 µM 3.43960011755396 0.000377189846389378 yes 13 0.000291287131995104 22 6708682 SGTC_2907 7721985 69.9 µM 3.42525961287028 0.000396165744688954 yes 14 0.000307106100632144 45 3267881 SGTC_710 3448-4187 58 µM 3.41483998480999 0.000410505061538897 yes 15 0.000319097457885811 81 3946412 SGTC_393 acivicin 6.25 µM 3.31081209659883 0.000582529392540599 yes 16 0.000465128259000721 32 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1423 4048-0112 5.59 µM 3.28490929991975 0.000634678263319365 yes 17 0.000510076029752174 48 X1423 SGTC_1591 genipin 88.4 µM 3.26257575591517 0.000683066463143107 yes 18 0.000552023300916056 30 442424 A DNA cross-linking agent. SGTC_2282 7944268 200 µM 3.23191939802715 0.00075503822202218 yes 19 0.000614808673047849 68 2970414 SGTC_176 1486-1328 72.834 µM 3.23118840230404 0.000756836676450019 yes 20 0.000616383269441122 98 22310231 SGTC_2568 diosmetin 100 µM 3.19953161904763 0.000838613695550343 yes 21 0.000688255436632311 59 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2819 7996655 46.38 µM 3.14265099214044 0.00100627063668764 no 22 0.000837126683081624 51 6456960 SGTC_2569 tetrandrine 100 µM 3.07980397376241 0.00122690235377997 no 23 0.00103568438682644 64 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3093 9117344 49.47 µM 3.07014500747862 0.00126449042847526 no 24 0.00106977432212017 58 24824913 SGTC_1357 1503-1303 39.5 µM 3.04443611970783 0.00136972717726979 no 25 0.00116558465752138 90 292895 SGTC_165 k038-0023 64.381 µM 3.00681861542378 0.00153817332790206 no 26 0.00131998617386479 136 46368543 SGTC_3094 9117742 49.47 µM 2.99508173086868 0.00159447269001246 no 27 0.00137185656526553 74 17149698 SGTC_2473 5854593 8.94 µM 2.98873095989021 0.0016257130316964 no 28 0.00140069342838244 41 2872951 SGTC_2973 9094665 17.96 µM 2.96310464529011 0.00175751849673441 no 29 0.00152276506374864 82 25237061 YIL048W NEO1 SGTC_2783 7738165 71.43 µM 2.93279969421255 0.00192589410757598 no 30 0.00167960269921069 73 17201110 SGTC_1293 1000-1278 195 µM 2.85806635885134 0.00240550151160375 no 31 0.00213115622597683 69 678847 SGTC_2654 protoveratrine a 100 µM 2.83658113257765 0.00256211828831822 no 32 0.00227996956043364 47 5702278 A heart drug and vasodilator. SGTC_2745 rifampicin 24.3 µM 2.80643730025476 0.00279739575202329 no 33 0.00250463300243549 20 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1899 st063254 59.6 µM 2.80332451688142 0.00282276954803692 no 34 0.00252893742576902 52 3093813 SGTC_600 1495-0418 41.6 µM 2.78092411277613 0.00301157393148978 no 35 0.00271022031375946 58 5377768 SGTC_2308 7584454 197.62 µM 2.75889837990369 0.00320823797867395 no 36 0.0028998283365772 95 893577 SGTC_1358 1509-0022 2.48 µM 2.74096465081462 0.00337681851569291 no 37 0.00306295488284943 73 3258434 SGTC_1325 1431-0015 227 µM 2.73158750493468 0.00346809867946636 no 38 0.00315150003056731 73 1103340 SGTC_1237 0330-0133 46.1 µM 2.68694865140062 0.00393373292654696 no 39 0.00360540184467445 84 X1237 YHR072W ERG7 SGTC_2522 biochanin a 4.94 µM 2.67437932140828 0.00407458119918415 no 40 0.00374338580947526 73 5280373 A possible chelator. SGTC_1383 3049-0032 20.7 µM 2.66524534300377 0.00417974831978655 no 41 0.00384660868117063 81 712864 SGTC_3011 9081274 71.4286 µM 2.62292466220889 0.00469938343032707 no 42 0.00435892737915748 99 6625322 SGTC_1871 st057448 67.3 µM 2.61888777908801 0.00475184226099989 no 43 0.00441084814962436 95 691747 SGTC_1680 diphenhydramine 100 µM 2.61664420931957 0.00478122241315297 no 44 0.00443994229072224 119 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.59774772989268 0.00503517481199726 no 45 0.00469187026180546 47 88881 An O-methylated flavonoid and antioxidant. SGTC_1791 st048313 56.1 µM 2.59133140966576 0.00512409733375822 no 46 0.00478026863512426 72 1204976 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.58771468769718 0.00517483444727317 no 47 0.00483074842863611 85 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2978 9011784 42.97 µM 2.58708185802499 0.00518375789955124 no 48 0.00483962972875685 146 2994934 SGTC_2930 9013230 14.89 µM 2.56902308078396 0.00544424145008237 no 49 0.00509928322631494 148 2995857 SGTC_1462 k081-0014 26.5 µM 2.56422365195664 0.00551539776689702 no 50 0.0051703444117531 55 3270634 SGTC_1432 4049-0298 68.4 µM 2.56263753187029 0.00553909457837967 no 51 0.00519402178713174 78 741646 SGTC_2563 tomatine 8.54 µM 2.55030169958498 0.00572650153488334 no 52 0.00538148668501548 172 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_126 0417-1624 672.48 µM 2.54747544456093 0.00577022259672476 no 53 0.00542527445792368 139 41912 YDL195W SEC31 SGTC_3301 9125354 19.7965 µM 2.54697697356336 0.00577796440407417 no 54 0.00543303014392443 80 41905162 SGTC_727 3032-0951 202 µM 2.54439065205796 0.0058182810098737 no 55 0.0054734290147145 109 3652836 SGTC_2760 etidronate 98.04 µM 2.54387059676446 0.00582641791203807 no 56 0.00548158454574417 119 3305 A chelator and antioxidant. SGTC_3123 9126162 49.47 µM 2.53072357759589 0.0060355007093961 no 57 0.00569137573669367 103 25239884 SGTC_2544 sphondin 68.51 µM 2.5235222106047 0.00615282368223393 no 58 0.00580928603972375 103 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2423 st077119 87.2 µM 2.52249681286049 0.00616969250662923 no 59 0.00582625030455994 100 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_382 3229-0966 23.2 µM 2.49719489317738 0.00659911836939088 no 60 0.00625900682448988 112 5722370 SGTC_2685 mycophenolic acid 18.85 µM 2.49333748442802 0.0066668573785872 no 61 0.00632742503051222 71 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1116 jasmonic acid  1.58368 µM 2.48093777234727 0.00688878729101445 no 62 0.00655186234143693 115 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1960 st011366 51.8 µM 2.4649631015522 0.00718430352566891 no 63 0.00685136808594499 76 3972846 SGTC_1727 st034309 9.9045 µM 2.45612711414073 0.00735251765859637 no 64 0.00702217349243783 188 870305 SGTC_86 0417-1630 471.922 µM 2.45187648917319 0.00743466811974053 no 65 0.00710567161343688 300 3634867 SGTC_1830 st055982 50.3 µM 2.44627425107041 0.00754417561579344 no 66 0.00721705791753832 113 455313 An antimicrobial agent. SGTC_2996 9066192 71.4286 µM 2.42688770448701 0.00793416773186948 no 67 0.0076144844029655 161 6472854 SGTC_1390 3413-2614 145 µM 2.42389159705926 0.00799599506902469 no 68 0.00767759413660465 142 3421432 SGTC_1498 4478-3555 97.6 µM 2.4201144143904 0.00807454394361313 no 69 0.00775781220367204 55 3437919 SGTC_3098 9119039 49.47 µM 2.41191768749511 0.00824733648565944 no 70 0.00793443183120506 136 17161528 SGTC_1676 st018489 23.4 µM 2.40313959574009 0.00843597817980425 no 71 0.00812749049657609 162 3696235 SGTC_2985 9022375 71.43 µM 2.39091419502329 0.00870500899496241 no 72 0.00840324007911686 158 4939335 SGTC_411 enrofloxacin 100 µM 2.36216578057404 0.00936747728650562 no 73 0.00908425774753011 105 71188 A bacterial gyrase inhibitor. SGTC_114 0364-0001 490.298 µM 2.34667892063226 0.00974231144330464 no 74 0.00947078476335968 184 4003655 SGTC_2746 daunorubicin 9.88 µM 2.34001926248745 0.0099074849586115 no 75 0.00964137266510473 48 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1424 4048-1941 275 µM 2.3343598246199 0.0100497674799845 no 76 0.0097884443014986 144 X1424 SGTC_2040 5100729 123 µM 2.33058891636798 0.0101455579610673 no 77 0.00988752324289712 156 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1305 1181-0477 144 µM 2.32993840908795 0.0101621627800863 no 78 0.00990470330730094 132 6252086 SGTC_91 0417-1751 58.384 µM 2.31533211509962 0.0105412957224377 no 79 0.010297381748393 215 6795624 SGTC_801 0866-0028 10.1 µM 2.31207576389798 0.0106274810542602 no 80 0.0103867542471381 182 6849771 SGTC_1119 parthenolide 318.541 nM 2.30964036112123 0.0106923390235245 no 81 0.0104540365659431 211 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1910 st062352 60.4 µM 2.30209343338117 0.0108955175437193 no 82 0.0106649518331151 176 2245730 SGTC_691 1548-0686 185 µM 2.29174264514736 0.0111796414083871 no 83 0.0109602490218066 197 46495133 SGTC_1421 4029-0249 71.4 µM 2.28982876903043 0.0112328761634161 no 84 0.0110156223691113 154 2894095 SGTC_1299 1079-1439 3.74 µM 2.28725258933266 0.0113048808481983 no 85 0.0110905420232888 127 323161 SGTC_1382 3002-2117 298 µM 2.28463383927049 0.0113784861879068 no 86 0.0111671535000062 124 1497314 SGTC_2730 imipramine 71.33 µM 2.27708471535157 0.0115930048486318 no 87 0.0113905836243036 199 3696 A tricyclic antidepressant. SGTC_1707 st032323 6.317 µM 2.27399264707235 0.0116818788316701 no 88 0.0114832143111676 216 3132057 YMR211W DML1 SGTC_3259 9138485 49.47 µM 2.25585066379455 0.0122153324420135 no 89 0.0120399925903622 156 17646153 SGTC_2127 5253358 187.912 µM 2.22873006674421 0.0130521284290954 no 90 0.0129159352364633 160 20612 SGTC_717 1532-0246 73.2 µM 2.2221182807138 0.0132634910018178 no 91 0.0131376565807074 185 9561992 SGTC_3162 9099653 49.47 µM 2.21230612410643 0.0135826092711474 no 92 0.01347276012349 107 25237511 SGTC_791 1348-1292 225 µM 2.20481540971608 0.0138306678152747 no 93 0.0137335251325475 234 5437054 SGTC_2117 5521686 200 µM 2.20336259537903 0.0138792281788339 no 94 0.013784601173271 166 803312 SGTC_580 1123-0028 41 µM 2.20141147690373 0.0139446756345682 no 95 0.0138534536235554 234 1677248 YPR107C YTH1 SGTC_1112 tnp00069 1.16933 µM 2.19314071403328 0.0142250692422801 no 96 0.0141486212106544 184 145826 SGTC_1064 honokiol 6.76 µM 2.18230283302908 0.0145998346480135 no 97 0.0145435950344614 176 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1839 st053978 48 µM 2.17759583519924 0.0147652267716822 no 98 0.0147180699466036 173 3788398 SGTC_2598 perillyl alcohol 100 µM 2.17293042262945 0.014930745377689 no 99 0.0148927771693442 209 10819 An apoptosis inducer. SGTC_786 4544-0069 423 µM 2.1457060383197 0.0159287588791848 no 100 0.0159482195665779 205 748821 YLR208W SEC13 SGTC_3350 9150499 3.57 µM 2.13129735386958 0.0164797359911376 no 101 0.0165323264667626 249 4910996 YPR165W RHO1 SGTC_3265 9137266 49.47 µM 2.12603532262755 0.0166849796520866 no 102 0.0167501592567034 132 17224265 SGTC_1965 Pectolinarigenin 58.4 µM 2.11376961577297 0.01717190562115 no 103 0.0172674746411708 160 5320438 An anti-inflammatory. SGTC_635 k038-0028 24.7 µM 2.11176003264832 0.0172528290224373 no 104 0.0173535184892151 219 4035102 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.09459663937153 0.0179573463232871 no 105 0.0181034321082471 178 4330530 SGTC_605 1315-0399 119 µM 2.09326189803704 0.0180131480338811 no 106 0.018162890966889 216 24020461 SGTC_2384 9036245 200 µM 2.07698562213171 0.0187055917169793 no 107 0.018901443129196 178 6462766 SGTC_1429 4049-0205 9.46 µM 2.07274604952464 0.0188896318721171 no 108 0.0190979598589909 199 22774478 SGTC_1682 st012968 530 nM 2.0707478914771 0.0189769047616834 no 109 0.019191181073431 171 24207270 SGTC_2572 astragaloside iv 100 µM 2.05197735400059 0.0198136113261659 no 110 0.0200859316539559 220 45006101 An anti-inflammatory agent. SGTC_1272 0839-0021 27 µM 2.02980719340826 0.0208419897730908 no 111 0.0211880707437749 218 5027250 SGTC_1250 0485-0349 40.2 µM 2.01103796458762 0.0217475988720993 no 112 0.0221607234137574 229 6842794 YDL195W SEC31 SGTC_1512 0259-0544 12.2 µM 1.98880751656586 0.0228629952881288 no 113 0.023361226406454 242 18476 SGTC_1666 st014829 29 µM 1.98587115050844 0.0230138676190845 no 114 0.0235238164193704 244 3858230 SGTC_3111 9122088 49.47 µM 1.97017187122462 0.0238348032687087 no 115 0.0244093380750527 132 16876704 SGTC_1693 xanthone 101.9 µM 1.96792029698826 0.023954535481604 no 116 0.0245386045207882 231 7020 An insecticide. SGTC_1275 0867-0008 21.1 µM 1.96726111893011 0.023989684170817 no 117 0.0245765575231465 228 3422836 SGTC_2629 bisabolol 100 µM 1.96648730879314 0.0240310005597211 no 118 0.0246211734542199 257 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2019 4016004 108 µM 1.96376553760504 0.0241768005969917 no 119 0.0247786441748161 214 45595336 SGTC_839 0122-0028 230 µM 1.95953925853521 0.0244046664236919 no 120 0.0250248334751048 303 759448 SGTC_593 1203-0218 61.7 µM 1.94014513694666 0.0254735754798492 no 121 0.026181026910884 242 3666956 SGTC_1789 tunicamycin 25 nM 1.93930167544101 0.0255209389437491 no 122 0.0262323075033912 245 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3261 9137475 49.47 µM 1.92665341154248 0.0262400744853298 no 123 0.0270114187623641 82 17027690 SGTC_2391 6285546 200 µM 1.91548491187693 0.0268890864712079 no 124 0.0277153457590108 282 846083 SGTC_3052 9092717 49.47 µM 1.89801496001134 0.0279311240223781 no 125 0.0288470556794405 254 25237534 SGTC_2469 5655019 90.81 µM 1.89307602505709 0.02823174524883 no 126 0.0291738799853973 260 2788239 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.89183300584212 0.0283078276467999 no 127 0.0292566170875094 121 6708630 An antioxidant. SGTC_994 3910-0338 138 µM 1.88815457572616 0.0285339763329952 no 128 0.0295026009646017 291 3479481 SGTC_1638 st008370 60.6 µM 1.88329036850075 0.0288353320016187 no 129 0.0298305139852659 287 24207134 SGTC_2466 5983409 37.09 µM 1.87847608549417 0.0291361952366709 no 130 0.030158032787745 237 2879657 SGTC_2099 5377090 177.372 µM 1.87701110544008 0.0292282634146345 no 131 0.0302582858983234 283 2243829 SGTC_121 0557-0495 61.343 µM 1.87680609297661 0.0292411668876896 no 132 0.030272337540938 408 3104427 SGTC_3180 9109287 49.47 µM 1.87046540829001 0.0296425913608937 no 133 0.0307096081497782 222 18891271 SGTC_350 k064-0020 19.8 µM 1.86865201553348 0.0297582334486693 no 134 0.0308356219896071 296 2790705 SGTC_1186 1319-0216 26 µM 1.86060418985974 0.0302759780053929 no 135 0.0314000463617688 265 4565136 SGTC_2377 9073351 62.6 µM 1.85910832471414 0.0303730302538965 no 136 0.0315058927693604 274 7337946 YHR072W ERG7 SGTC_270 tamoxifen 5.46 µM 1.83931819600219 0.0316814604068509 no 137 0.0329341991204555 292 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2379 9035213 200 µM 1.82611677285034 0.0325799119969463 no 138 0.0339163371164753 274 646551 SGTC_1341 1486-1360 280 µM 1.8168444059039 0.0332234447655263 no 139 0.0346204706110612 293 3976547 SGTC_1146 3579-1023 7 µM 1.81336804135014 0.033467398806733 no 140 0.0348875376419672 312 X1146 SGTC_1545 lovastatin 49.4 µM 1.80962531404572 0.0337316914845607 no 141 0.0351769557960269 321 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1523 st012844 44.7 µM 1.80889645681916 0.0337833589967652 no 142 0.035233545491272 301 4274103 SGTC_3107 9121808 49.47 µM 1.80627941151283 0.0339694140050023 no 143 0.0354373530601112 183 662681 SGTC_137 0438-0332 85.389 µM 1.802952007834 0.0342071869383066 no 144 0.0356978760684013 452 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_787 4152-0075 138 µM 1.80030736632636 0.0343971447275546 no 145 0.0359060592048148 283 9566539 SGTC_1329 1447-1697 50.6 µM 1.79504054234062 0.0347780293261417 no 146 0.0363236203644469 299 2840515 SGTC_1413 3910-0535 34.4 µM 1.78689731147439 0.0353737397473764 no 147 0.0369770435678225 285 2876951 SGTC_2707 st078556 66.6 µM 1.77945440106357 0.0359255140499237 no 148 0.0375826471797983 255 17250899 SGTC_77 0828-0286 12.516 µM 1.77670016492794 0.0361314761547544 no 149 0.0378087925800297 320 745345 SGTC_2611 pyromycin 23.93 µM 1.77654618250034 0.0361430194596618 no 150 0.037821468511146 312 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1082 camptothecin 424.86 nM 1.77630862126115 0.0361608341798275 no 151 0.0378410315058083 301 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2888 9058547 12.99 µM 1.77536787403227 0.0362314514485816 no 152 0.0379185824673965 221 16476514 SGTC_726 3448-4391 34.2 µM 1.77507939408714 0.0362531288248573 no 153 0.0379423894177102 312 1356692 SGTC_2471 5466956 24.79 µM 1.76642070148274 0.0369087304333564 no 154 0.0386626472820345 241 724419 SGTC_2411 st077133 39.94 µM 1.76441269510368 0.0370621451661905 no 155 0.038831261171059 351 1403142 YNL221C POP1 SGTC_356 1634-0012 32.5 µM 1.75850333901902 0.0375166550795958 no 156 0.0393309519696488 328 735457 SGTC_1169 aniline yellow 25.8 µM 1.75403362662611 0.0378634517313391 no 157 0.0397123727034361 256 6051 A DNA damaging agent. SGTC_526 4469-0568 170 µM 1.75326629338603 0.0379232499671476 no 158 0.039778154200929 319 2901964 SGTC_776 4476-4378 112 µM 1.75326033065355 0.0379237149440999 no 159 0.0397786657172396 262 2892008 SGTC_1657 st012939 43.4 µM 1.74829819821832 0.038312280338797 no 160 0.0402062025413781 257 24207257 SGTC_523 1934-0222 13.7 µM 1.74151876636161 0.0388483919615355 no 161 0.040796343344122 329 1361595 SGTC_684 1140-0066 328 µM 1.73862727517384 0.0390788997890218 no 162 0.041050172834629 356 6813534 SGTC_1930 st074634 34.3 µM 1.73726387582846 0.0391879747517807 no 163 0.0411703023662004 324 684253 YOR116C RPO31 SGTC_2015 5119600 184 µM 1.73131905992803 0.0396664724049012 no 164 0.0416974369098681 318 2828786 SGTC_1279 0874-0590 65.2 µM 1.72463300443254 0.0402102974923534 no 165 0.0422968158078949 314 3523074 SGTC_2293 7624732 200 µM 1.72437640478774 0.0402312886713511 no 166 0.0423199571403408 298 894453 SGTC_1975 st070967 30.8 µM 1.72204751415051 0.0404222112418926 no 167 0.042530455844072 359 261391 SGTC_2070 5230947 200 µM 1.71725877514289 0.040817103962164 no 168 0.0429659503882578 307 2835538 SGTC_1292 0kpi-0043 232 µM 1.71049642692456 0.0413800708302588 no 169 0.0435870567988528 307 3333905 SGTC_3157 9099274 49.47 µM 1.70371573111296 0.0419508673462633 no 170 0.0442171038835181 273 17217662 SGTC_1665 st014639 11.4 µM 1.70366121885625 0.0419554818661882 no 171 0.0442221986295924 364 981133 YIL048W NEO1 SGTC_744 1594-0068 283 µM 1.70320018223627 0.0419945255378714 no 172 0.0442653062971847 381 668392 SGTC_2966 9084041 48.03 µM 1.7028889014265 0.0420209035131165 no 173 0.0442944307041167 321 17741380 SGTC_2891 9063876 19.48 µM 1.70187665741003 0.0421067739311392 no 174 0.0443892462069395 213 6472478 SGTC_3127 9126946 49.47 µM 1.70156357627468 0.0421333618850653 no 175 0.0444186051784204 293 27243249 SGTC_824 1304-0008 100 µM 1.69941614193973 0.0423160959842284 no 176 0.0446204013276768 367 768245 SGTC_2844 9010103 25.97 µM 1.69734587077783 0.0424928704439704 no 177 0.0448156448585665 369 2480525 SGTC_2420 aureobasidin a 50 nM 1.6936564368841 0.0428093807202346 no 178 0.0451652934961686 388 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1845 st056753 3.01 µM 1.69314056821584 0.0428537876704541 no 179 0.0452143569510305 359 5375839 SGTC_1802 st050112 57.9 µM 1.69175962410702 0.0429728451851769 no 180 0.045345907427836 312 4662563 SGTC_439 amiodarone 34.4 µM 1.68679347719892 0.0434032098344299 no 181 0.0458215350719042 405 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_934 2950-0684 338 µM 1.68676799279193 0.04340542724554 no 182 0.0458239861148286 347 1121253 SGTC_1319 1306-0155 43.7 µM 1.68492168787849 0.0435663186554909 no 183 0.0460018408090327 374 3122360 SGTC_1931 st074438 57.1 µM 1.68225996131408 0.0437991146227683 no 184 0.0462592207213976 305 2787313 SGTC_974 1326-0144 138 µM 1.6818330856262 0.0438365425937376 no 185 0.0463006055381683 375 5411856 SGTC_12 0849-0099 9.267 µM 1.67274987189707 0.0446390812675838 no 186 0.0471882734429085 311 6071388 SGTC_530 4358-1714 28 µM 1.6726438601633 0.044648517230598 no 187 0.0471987135396482 404 1564641 SGTC_284 0988-0104 32.6 µM 1.67077387380304 0.0448152264745853 no 188 0.0473831754282219 326 4666532 SGTC_1213 1315-0166 115 µM 1.66907018802847 0.044967545994835 no 189 0.0475517353278841 297 768401 SGTC_695 3505-6186 243 µM 1.66698767220873 0.045154300866758 no 190 0.0477584281011273 320 1819379 SGTC_3324 9138759 60.749 µM 1.66190420306665 0.0456127955263629 no 191 0.0482659919140947 328 45595710 SGTC_2056 5235370 200 µM 1.65015531167482 0.0466867925822087 no 192 0.0494555871319428 368 5511916 SGTC_2439 5492030 7.2 µM 1.64279914572213 0.047369504862358 no 193 0.0502122485139737 321 5722370 SGTC_1972 st070201 17.4 µM 1.64235465934293 0.0474110117876662 no 194 0.0502582627787354 339 2829099 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.63773823883645 0.0478438265019016 no 195 0.0507381550727673 341 4213774 SGTC_933 2914-0560 114 µM 1.637237599821 0.0478909536754694 no 196 0.0507904167552851 394 463887 SGTC_2828 7998861 71.43 µM 1.63674750286043 0.0479371244722455 no 197 0.0508416194635933 276 2988188 SGTC_2739 tacrine 100.86 µM 1.63502749254784 0.0480994443157883 no 198 0.0510216422234081 312 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_323 4013-0906 34.3 µM 1.63431202320629 0.0481670935841964 no 199 0.0510966751953562 316 2910086 SGTC_1627 st003713 25.6 µM 1.62718846974553 0.048844801991575 no 200 0.0518485379149439 464 16195070 YER133W GLC7 SGTC_1440 4100-1550 40 µM 1.62528498500339 0.0490271766963516 no 201 0.0520509246361272 284 742806 SGTC_2999 9069765 71.4286 µM 1.61788467645243 0.0497413813425662 no 202 0.0528437266140948 365 2097066 SGTC_3024 9090631 49.47 µM 1.61621442202017 0.0499037204076666 no 203 0.0530239808508212 288 25236383 SGTC_3270 9137563 49.47 µM 1.61598239850669 0.0499263051402359 no 204 0.0530490594071719 307 17015724 SGTC_3010 9080089 71.4286 µM 1.61550990977472 0.0499723215064772 no 205 0.053100158030874 348 17027233 SGTC_1346 1488-2224 62.4 µM 1.61463707482847 0.0500574171202629 no 206 0.0531946558539541 355 3722427 SGTC_1617 st002906 78 µM 1.60834121356907 0.0506746490585011 no 207 0.0538802345043691 390 5150859 SGTC_1834 st055981 52.8 µM 1.60640296883303 0.0508658856888632 no 208 0.0540926995029349 365 471719 YDL150W RPC53 SGTC_1202 1988-0068 29.6 µM 1.60610665276234 0.0508951722391219 no 209 0.0541252392036719 376 2850480 SGTC_3333 9141820 12.094 µM 1.60246733755891 0.0512559617755956 no 210 0.0545261523318433 330 1939433 SGTC_3099 9120367 49.47 µM 1.59216080774014 0.0522887652222949 no 211 0.0556742884576285 373 24824940 SGTC_2351 9026858 72.31 µM 1.58557423916724 0.0529574055566243 no 212 0.0564179618938796 340 1409300 SGTC_3316 9136639 10.545 µM 1.57882325032126 0.053649756266088 no 213 0.0571883020330914 337 4903665 SGTC_902 1120-0002 2.07 µM 1.57781127216076 0.0537541553095303 no 214 0.057304486726668 432 3280475 SGTC_584 0986-0246 15.4 µM 1.57258260407155 0.0542961276576867 no 215 0.0579077491596908 418 53315 YDR232W HEM1 SGTC_1391 3442-0225 151 µM 1.56947952647613 0.0546198126857944 no 216 0.058268123174629 317 5227075 SGTC_1495 4469-0029 237 µM 1.56805186723276 0.0547692447821065 no 217 0.0584345141303697 531 793680 SGTC_2475 5812728 15.03 µM 1.56259533241663 0.0553433565121587 no 218 0.0590739034278071 414 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3012 9080433 71.4286 µM 1.55850738874744 0.0557765770711555 no 219 0.0595565089250142 393 17688859 SGTC_1799 st045822 46.1415 µM 1.55843746841757 0.0557840100995219 no 220 0.0595647902233582 369 3674992 SGTC_2296 7971656 126.45 µM 1.54686233818646 0.0570253410453477 no 221 0.0609482221732951 420 666570 SGTC_3118 9124250 49.47 µM 1.54679537183243 0.0570325853558824 no 222 0.0609562982970839 343 1504786 SGTC_2954 9074818 52.69 µM 1.54449964808974 0.0572813714391912 no 223 0.0612336682231418 406 16648742 SGTC_1659 st012954 42.1 µM 1.538838900348 0.0578984723833653 no 224 0.0619218152395603 353 24207262 SGTC_1485 3909-9022 254 µM 1.53709195789882 0.0580899651961278 no 225 0.0621353960313055 398 714516 SGTC_2430 5571206 200 µM 1.5369673379985 0.0581036445237047 no 226 0.0621506539664589 454 1731771 SGTC_2862 9027634 71.43 µM 1.53669859474743 0.0581331526563285 no 227 0.0621835677049671 392 5012562 SGTC_2679 rapamycin 1 nM 1.53563817973284 0.0582497016219812 no 228 0.0623135723924291 539 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_407 eburnamonine 100 µM 1.53116392282306 0.0587434842738018 no 229 0.0628644423475437 339 3195 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.52059065609367 0.0599234131080214 no 230 0.0641812965491151 436 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_644 1498-1197 63.3 µM 1.52031982772424 0.0599538783796811 no 231 0.0642153065524333 434 6741615 SGTC_1952 st077036 64.1 µM 1.52008748576644 0.0599800240109052 no 232 0.0642444946828269 450 2937007 SGTC_1812 st052057 4.327 µM 1.51309975098271 0.0607705398882378 no 233 0.0651271614370275 423 3645418 SGTC_3133 9127736 49.47 µM 1.51208414673599 0.0608861093178517 no 234 0.0652562286567261 411 27243420 SGTC_2812 7970281 58.44 µM 1.50956178954982 0.0611738812241096 no 235 0.065577638770572 440 2233435 SGTC_1021 4476-0760 85.3 µM 1.50485404752108 0.0617138223905553 no 236 0.0661808023638618 433 746768 SGTC_3343 9148379 18.9835 µM 1.50242724293585 0.0619936074995726 no 237 0.066493402504131 402 1955036 SGTC_871 0574-0004 149 µM 1.50180994027542 0.0620649336922465 no 238 0.0665731002094819 469 9551173 SGTC_3150 9097574 49.47 µM 1.50176322636396 0.0620703338528127 no 239 0.0665791342810778 361 17217476 SGTC_1218 1348-1416 30.7 µM 1.50091116180811 0.0621688974465561 no 240 0.0666892704074636 423 6787668 SGTC_2362 9071156 126 µM 1.50054450572713 0.0622113483857751 no 241 0.0667367069920595 426 653133 SGTC_708 3448-5400 146 µM 1.49975594616933 0.0623027233359561 no 242 0.0668388163203836 445 3462195 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.4934206807367 0.063040630219616 no 243 0.0676635514183272 435 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1170 0310-0127 64.8 µM 1.48364260010729 0.0641928818572213 no 244 0.0689518807635487 444 774975 SGTC_3210 9128157 49.47 µM 1.48239935507251 0.0643405517774048 no 245 0.0691170327430584 439 17590849 SGTC_872 0588-0139 234 µM 1.4787898793635 0.064770773331677 no 246 0.0695982407923526 462 2047100 SGTC_2943 9068529 45.32 µM 1.47773843894393 0.0648965161007345 no 247 0.0697389007585402 475 3270634 SGTC_2710 st078562 53.7235 µM 1.47548767851834 0.0651663236732774 no 248 0.0700407392441276 412 17250908 SGTC_2481 5478948 45.16 µM 1.4736016096793 0.0653930838250583 no 249 0.070294443857214 440 77792 SGTC_2540 epiandrosterone 100 µM 1.47243698513215 0.0655334108062841 no 250 0.0704514559214351 589 441302 A steroid. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.46965800655146 0.0658691965375522 no 251 0.0708272007238527 426 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_891 0929-0073 133 µM 1.46819796681365 0.0660461475678313 no 252 0.0710252281994306 418 5603632 SGTC_3271 9137798 49.47 µM 1.46802122844696 0.0660675925231166 no 253 0.0710492283248864 358 6498326 SGTC_2650 prasterone 100 µM 1.46623085259 0.0662851361079482 no 254 0.0712927030318 329 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3058 9093861 49.47 µM 1.46003113866742 0.0670427343017085 no 255 0.0721407580952441 448 17217477 SGTC_2755 lomerizine 42.69 µM 1.45782085140452 0.0673144424434539 no 256 0.0724449646527904 468 3949 A calcium channel blocker. SGTC_3260 9137109 49.47 µM 1.45247165304136 0.0679755359978407 no 257 0.0731852527873144 349 17478346 SGTC_1739 st037196 92.5 µM 1.45029115063035 0.0682464525150585 no 258 0.0734886728807315 457 612214 SGTC_921 1561-0023 372 µM 1.44444400793041 0.0689770442167528 no 259 0.0743070595823465 466 24050882 SGTC_2093 5331342 194.4 µM 1.4422236431072 0.0692560493802216 no 260 0.074619646391379 456 33839 SGTC_45 0kpi-0036 14.9 µM 1.44193394544128 0.0692925160499956 no 261 0.0746605044344197 417 2795021 SGTC_1605 st000082 49.1 µM 1.43952449525078 0.0695963870736034 no 262 0.0750009874513731 420 1114022 SGTC_367 0335-0881 7.1 µM 1.43846482829254 0.0697303527893779 no 263 0.0751511050001908 494 23828853 SGTC_686 1319-0111 510 µM 1.43425888251294 0.0702640370282888 no 264 0.0757491996541051 490 4562600 SGTC_2525 harmine 47.85 µM 1.43301587854431 0.0704223592127558 no 265 0.0759266498085757 384 5280953 A monoamine oxidase inhibitor SGTC_262 fenpropimorph 62.5 µM 1.43135458638575 0.0706343870889513 no 266 0.0761643084358764 404 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1454 4239-0054 42.6 µM 1.42296160224978 0.0717130770980031 no 267 0.0773736433269494 521 1340767 SGTC_1134 3477-0009 42.5 µM 1.42032379641585 0.0720546922681087 no 268 0.0777567182178227 518 3973534 SGTC_219 mitoxanthrone 164.414 µM 1.42013676676005 0.0720789612615777 no 269 0.0777839341252248 472 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1606 st000094 49.2 µM 1.42007875386888 0.0720864902953427 no 270 0.0777923774291216 481 1242210 SGTC_1784 st039334 36.3 µM 1.41891230698571 0.0722380021590882 no 271 0.0779622919171827 462 3496984 SGTC_1024 4507-0395 26 µM 1.41858022248546 0.0722811818072013 no 272 0.0780107176065492 467 4201836 SGTC_583 1488-1091 88.9 µM 1.41022039057068 0.0733747060605895 no 273 0.0792373083745912 570 4303273 SGTC_1087 pterostilbene 9.05 µM 1.40950076672367 0.0734694262048866 no 274 0.0793435734520551 514 5281727 Similar to reservatol, lowers cholesterol. SGTC_2029 5175081 200 µM 1.40889243617812 0.0735495703325158 no 275 0.0794334882332287 510 1380876 SGTC_2334 9017922 200 µM 1.40713429712492 0.0737815710529432 no 276 0.0796937848841009 452 3163164 SGTC_59 0330-0160 1.33 µM 1.40554787122336 0.0739913925183685 no 277 0.0799292123465994 632 4293482 SGTC_1338 1486-1223 76 µM 1.40324585221184 0.0742966690231223 no 278 0.0802717694115541 506 3444526 SGTC_653 0203-0016 55.2 µM 1.40023275036255 0.0746976961928671 no 279 0.0807218157893601 479 295302 SGTC_770 0389-1121 67.2 µM 1.39956427251781 0.0747868903686104 no 280 0.0808219195062851 546 6753108 SGTC_2636 apigenin dimethyl ether 100 µM 1.39749312261228 0.0750637572942889 no 281 0.0811326666754395 526 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3001 9076041 71.4286 µM 1.39676967464871 0.075160650267041 no 282 0.0812414221528103 469 16004211 SGTC_2061 5245884 80.95 µM 1.39405463884866 0.0755251316269106 no 283 0.0816505528395208 507 573863 SGTC_3137 9097352 49.47 µM 1.39359360956486 0.0755871562819266 no 284 0.0817201796843019 527 44120435 SGTC_2921 7974240 10.71 µM 1.39099102337731 0.0759380238373385 no 285 0.0821140744185179 485 2979074 YDR527W RBA50 SGTC_1947 st076332 61.6 µM 1.38985580999745 0.0760914554758538 no 286 0.0822863333551322 404 24208416 SGTC_268 camptothecin 39.6153 µM 1.38560727830326 0.0766677675845939 no 287 0.0829334272854917 603 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1600 coumarin 106 71.1 µM 1.38471098728474 0.0767897721314396 no 288 0.0830704290415464 506 100336 A hepatotoxic, DNA x-linker. SGTC_1534 6-azauridine 81.6 µM 1.38412358373967 0.0768698104665447 no 289 0.0831603083653248 547 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1742 st038235 28.8875 µM 1.38397702137208 0.0768897906201191 no 290 0.0831827454443255 531 564103 YBR002C RER2 SGTC_1232 0279-0259 161 µM 1.37718576887039 0.07781994598056 no 291 0.0842274102782082 502 1560000 SGTC_1626 st003712 1.76 µM 1.37684252045023 0.0778671843111385 no 292 0.0842804707338499 472 24207035 SGTC_283 0987-0079 11.7 µM 1.37445938878517 0.0781957544615066 no 293 0.0846495548705863 544 411556 SGTC_2381 9035592 200 µM 1.37368854848972 0.0783022575016201 no 294 0.0847691967647399 421 4749657 SGTC_3075 9116269 49.47 µM 1.36731084259535 0.0791876563267003 no 295 0.0857639472941662 503 17015205 YNL244C SUI1 SGTC_3218 9131285 49.47 µM 1.36574061894636 0.0794068045304704 no 296 0.0860101951589937 586 17156417 SGTC_390 dec-rvkr-cmk 16.7 µM 1.36381152798163 0.0796766660486051 no 297 0.0863134455700756 526 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.35996884009055 0.0802162883131087 no 298 0.0869198923216929 511 16623 A steroid. SGTC_3319 9138450 16.7555 µM 1.35516812293806 0.0808943205114059 no 299 0.0876819991784437 478 2029690 SGTC_1792 st045773 43.6 µM 1.35510136441467 0.080903779598407 no 300 0.0876926320294546 499 2919270 SGTC_2084 5306078 60.6385 µM 1.35363072273049 0.0811123682581529 no 301 0.0879271100738903 507 679340 SGTC_1838 st055369 84.5 µM 1.35343061923332 0.0811407813028191 no 302 0.0879590505339981 456 676036 SGTC_1667 st014849 34.6 µM 1.34410971600713 0.0824726108602022 no 303 0.0894564553489245 528 5348460 SGTC_95 0471-0001 561.058 µM 1.34300324465388 0.0826317969810101 no 304 0.0896354616075447 531 4015405 SGTC_540 1187-0821 17.3 µM 1.34176580401268 0.0828100992376583 no 305 0.0898359715710825 493 847520 SGTC_1001 4048-4355 44.4 µM 1.34154861121369 0.08284142429011 no 306 0.0898711989951004 507 21824233 SGTC_518 1021-0119 62.6 µM 1.34138527753049 0.0828649872797282 no 307 0.0898976975428813 517 1097762 SGTC_1681 tripelennamine 100 µM 1.34125148579779 0.0828842922185935 no 308 0.0899194076588196 447 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1327 1436-0082 2.18 µM 1.33556447400844 0.0837080086669862 no 309 0.0908458342342565 505 15992205 SGTC_3336 9143619 71.43 µM 1.33483278621539 0.0838144325284551 no 310 0.0909655401106561 566 45595730 SGTC_2495 cafestol 54.53 µM 1.32816450320502 0.0847890208721887 no 311 0.0920618840859759 493 16667697 An anti-infammatory. SGTC_1954 st077032 68.9 µM 1.32387445084446 0.0854205008857427 no 312 0.0927723723565472 478 698907 SGTC_274 sirtinol 40.1 µM 1.32332495447476 0.0855016385710162 no 313 0.0928636682270938 522 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 1.32255854156728 0.0856149021501562 no 314 0.0929911145295957 509 16667744 Haematoxylin. SGTC_2444 5485484 36.41 µM 1.32154093824688 0.0857654612159496 no 315 0.0931605308630853 553 6790631 SGTC_196 k015-0023 18.111 µM 1.31979046389864 0.0860249154659862 no 316 0.0934524931679865 567 5211998 SGTC_2467 5474540 200 µM 1.31891683956435 0.0861546230175606 no 317 0.0935984578839434 534 5413519 SGTC_1165 k072-0275 30.3 µM 1.31852062207649 0.0862134978747291 no 318 0.0936647131665001 504 6153523 YGL055W OLE1 SGTC_855 0428-0020 25 µM 1.31429580401451 0.086843145490279 no 319 0.094373339388286 498 6812414 SGTC_36 0335-0881 14.2 µM 1.31377839369117 0.0869204935169712 no 320 0.0944603953324361 604 23828853 SGTC_2142 5622915 118.518 µM 1.31376945376856 0.0869218304043311 no 321 0.0944619000232506 484 5322196 SGTC_170 4197-0004 226 µM 1.31236011124519 0.087132777413152 no 322 0.0946993294774343 475 218692 SGTC_1025 k007-0731 70 µM 1.30598318858591 0.0880920400879469 no 323 0.0957791373301726 511 6256118 SGTC_2023 5144124 124 µM 1.30575224344779 0.0881269276678627 no 324 0.095818412653147 539 2830192 SGTC_1223 0764-0573 147 µM 1.30567048442814 0.0881392810103896 no 325 0.0958323197116867 584 1609797 SGTC_138 0850-0259 40.9225 µM 1.30550440574779 0.0881643785687153 no 326 0.0958605739601184 678 6813004 SGTC_259 usnic acid 108.925 µM 1.30509182338948 0.0882267504446289 no 327 0.0959307913310924 553 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.30383170483878 0.0884174516880533 no 328 0.0961454850286008 340 4000243 SGTC_2063 5246145 200 µM 1.30277359185614 0.0885778193154715 no 329 0.096326034532209 565 711240 SGTC_2280 7785178 200 µM 1.30142279605175 0.0887828606887242 no 330 0.0965568874639904 509 2954328 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.30076066577133 0.0888834964329109 no 331 0.0966701948060767 541 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1115 galangin 695.678 nM 1.30039489652293 0.0889391253102992 no 332 0.0967328290937119 587 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_826 1683-5028 118 µM 1.29777070668533 0.0893389916298568 no 333 0.0971830692384868 524 722377 SGTC_3299 9121982 43.1275 µM 1.29724080022392 0.0894198992657893 no 334 0.0972741732090272 560 17594604 YPL160W CDC60 SGTC_1915 st067105 30.6 µM 1.29324424270921 0.0900318614448426 no 335 0.0979632991010329 553 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1991 st073000 8.92 µM 1.29298950580345 0.0900709725885002 no 336 0.098007344333381 614 4301969 YIL048W NEO1 SGTC_831 k061-1017 217 µM 1.29292020387951 0.0900816150740621 no 337 0.0980193294788684 721 1240153 SGTC_328 k915-0120 63.5 µM 1.29169864478276 0.0902693595868088 no 338 0.0982307634918286 533 6624543 SGTC_2847 9005661 71.43 µM 1.29088916381896 0.0903939307694072 no 339 0.0983710567268818 405 2991449 SGTC_1455 4262-0120 131 µM 1.29076409804761 0.0904131885445161 no 340 0.0983927452783975 569 1529587 SGTC_1368 1852-0141 284 µM 1.29013442712162 0.0905101922989033 no 341 0.0985019942227621 537 2838987 SGTC_1253 0550-0034 176 µM 1.29003532116815 0.0905254670700884 no 342 0.0985191973552862 516 5969915 SGTC_2987 9018338 71.43 µM 1.28512371457636 0.0912848713639011 no 343 0.0993745278998021 563 5055682 SGTC_1759 st043059 70 µM 1.28428774064701 0.0914145938318799 no 344 0.0995206473603498 575 669426 SGTC_3119 9125183 49.47 µM 1.27958313455077 0.0921471814893197 no 345 0.100345892231074 423 22695334 SGTC_2507 purpurin 79.67 µM 1.27730026903112 0.0925042249358611 no 346 0.100748129345579 577 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_667 1498-1044 59 µM 1.27364392344083 0.0930782134981357 no 347 0.10139481914614 578 6739982 SGTC_2866 9034245 58.44 µM 1.27075694511165 0.093533280091484 no 348 0.101907565036688 497 6462273 SGTC_807 1315-0151 48 µM 1.26876231111102 0.0938486472671145 no 349 0.102262925500691 655 4011080 SGTC_1705 st027868 56.3335 µM 1.26610704893684 0.094269681795248 no 350 0.102737379651476 552 292948 SGTC_1916 st067606 49.2 µM 1.25936039241315 0.0953457369882089 no 351 0.103950094377728 626 19590279 SGTC_1417 3966-0327 90.4 µM 1.25411090217814 0.0961892370889295 no 352 0.104900849126192 639 651118 SGTC_1034 k072-0165 12.7 µM 1.24763649298922 0.0972370987909704 no 353 0.106082103978835 615 5835461 SGTC_1323 1348-1351 11.2 µM 1.24329978615838 0.0979436495125158 no 354 0.106878691495379 554 6989654 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.23940378053273 0.0985816016982096 no 355 0.107598001044695 622 2333 A French combination drug. SGTC_814 3342-0569 96 µM 1.23759167800872 0.098879359061672 no 356 0.107933750862489 620 4346283 SGTC_2606 farnesol 9.78 µM 1.23707408207676 0.0989645290301924 no 357 0.10802979040698 599 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3284 9108171 64.8615 µM 1.23279554832525 0.0996706142424802 no 358 0.10882602632141 552 8687505 SGTC_836 0330-0104 1.35 µM 1.23194173104164 0.0998119589475207 no 359 0.10898542563622 600 46494820 SGTC_2627 acetyl isogambogic acid 100 µM 1.22917551584273 0.100270896042308 no 360 0.10950300334646 567 6857789 A caspase activator and apoptosis inducer. SGTC_2395 5646831 180.19 µM 1.22870769659081 0.10034866299763 no 361 0.109590709735093 590 6808628 SGTC_2657 nystatin 74.44 µM 1.22747360363557 0.100554021050173 no 362 0.10982231852701 622 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1226 3909-7979 35.4 µM 1.22687764980583 0.100653299877927 no 363 0.109934290059194 652 6615510 SGTC_1152 3909-8331 15.9 µM 1.22377448104968 0.101171406460159 no 364 0.110518656780084 567 16001939 SGTC_2825 7998094 58.44 µM 1.2225461746939 0.101377021079822 no 365 0.11075057677371 582 2987815 SGTC_2601 securinine 100 µM 1.22228061667722 0.101421514649935 no 366 0.110800763348108 588 442872 A GABA receptor antagonist. SGTC_1506 4226-2149 212 µM 1.22062050311402 0.101699984895195 no 367 0.111114869841308 663 991114 SGTC_3161 9100388 49.47 µM 1.21966248772093 0.101860937107202 no 368 0.111296423762647 600 25236368 SGTC_1846 st056244 14.8 µM 1.21629966141771 0.102427379219705 no 369 0.111935395233389 642 5393182 SGTC_1220 1838-0075 193 µM 1.21475628645876 0.10268811426754 no 370 0.11222952887159 617 5529645 SGTC_2111 5486399 200 µM 1.2117966869714 0.103189452606806 no 371 0.112795108418574 673 689674 SGTC_425 3825-7017 13.1 µM 1.2116764021619 0.103209865649734 no 372 0.112818137805288 658 3397440 SGTC_3153 9100258 49.47 µM 1.21077617187508 0.103362733148965 no 373 0.112990599909778 565 25236848 SGTC_58 0957-0393 9 µM 1.20593494535146 0.104187637803412 no 374 0.113921287558077 852 6997992 SGTC_2089 5281248 129.67 µM 1.20112768902793 0.105011465966265 no 375 0.114850836883491 636 2737878 SGTC_1832 st054113 55 µM 1.19878195061724 0.105415166829405 no 376 0.115306371313643 576 1251267 SGTC_2607 solasodine 47.35 µM 1.19821176744737 0.105513464554882 no 377 0.115417292705837 636 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_671 0560-0003 407 µM 1.19568403277578 0.105950036160029 no 378 0.115909942338974 593 3238678 SGTC_3338 9144300 39.5675 µM 1.19417010752825 0.106212134344758 no 379 0.11620571680204 640 4901274 SGTC_634 1611-4317 11.2 µM 1.19150509774853 0.106674651194474 no 380 0.116727678299276 685 2843522 SGTC_1019 4262-0212 3.4 µM 1.19064583470163 0.106824087167087 no 381 0.116896325033353 701 4677213 SGTC_2146 5545642 200 µM 1.18959074417192 0.107007786378092 no 382 0.117103642768134 637 825326 SGTC_2524 avocatin b 10.57 µM 1.18857595334652 0.107184683974382 no 383 0.117303287543918 574 6710748 SGTC_1273 0849-0096 14.1 µM 1.18619640196026 0.107600312368596 no 384 0.117772373417865 639 5286025 SGTC_848 0368-0089 85.6 µM 1.18611600903958 0.107614374586784 no 385 0.117788244588821 661 762535 SGTC_1030 k029-0042 36.7 µM 1.1855801509549 0.107708139970093 no 386 0.117894072362474 689 6080581 SGTC_2418 pentamidine 31.67 µM 1.17433729011867 0.109689023767413 no 387 0.120129976264436 600 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_99 0109-0120 622.8 µM 1.17128950116371 0.110230492839395 no 388 0.120741215026555 590 759414 SGTC_765 1319-0117 244 µM 1.16939740667288 0.110567604656732 no 389 0.121121777104578 609 3487746 YGL099W LSG1 SGTC_1303 1160-0052 261 µM 1.16877693030904 0.110678314798025 no 390 0.121246758711358 647 3562476 SGTC_3355 9151058 44.0485 µM 1.16526173866918 0.111307022246379 no 391 0.121956530797414 632 17015728 SGTC_1696 st025591 34.7925 µM 1.15933415903621 0.11237297870325 no 392 0.123160001570453 667 2787147 SGTC_3121 9125696 49.47 µM 1.1566279812834 0.11286204812003 no 393 0.123712192562419 624 1235365 SGTC_3136 9095672 49.47 µM 1.15466137654628 0.113218411540009 no 394 0.124114560951622 576 17217380 SGTC_3041 9091929 49.47 µM 1.15418085168385 0.113305608130096 no 395 0.124213015636029 682 25236887 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.1525379838428 0.113604086633875 no 396 0.124550035276128 607 2346 DNA damaging agent; causes G2/M arrest. SGTC_3263 9137018 49.47 µM 1.15210556680311 0.113682741867903 no 397 0.124638847937659 618 43844957 SGTC_456 gingerol 170 µM 1.15066738801051 0.113944621090607 no 398 0.124934548979291 647 442793 A herb. SGTC_3248 9135562 49.47 µM 1.15002774504487 0.114061232227289 no 399 0.125066222017288 710 17650701 SGTC_1188 1403-0014 4.57 µM 1.14929096478159 0.114195657464653 no 400 0.12521801123842 728 9614867 SGTC_1045 1348-1485 165 µM 1.14747606089625 0.114527267063901 no 401 0.125592460740826 712 6810614 SGTC_2705 st078069 42.8 µM 1.14620427430285 0.114760049218995 no 402 0.12585531987058 612 1530061 SGTC_1015 4130-4525 82 µM 1.14585803709224 0.114823481193941 no 403 0.125926948287774 669 1363237 SGTC_3108 9121785 49.47 µM 1.14578629746166 0.114836627286166 no 404 0.125941793101646 650 17140271 SGTC_2772 vinpocetine 57.06 µM 1.14563801761067 0.114863802559177 no 405 0.125972479965221 644 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2137 5261020 140 µM 1.14559021543565 0.114872564246768 no 406 0.125982373848898 646 763655 SGTC_260 nsc-65238 3.989 µM 1.14551726633843 0.114885936044216 no 407 0.125997473576135 631 3246252 SGTC_1176 0848-0131 83.3 µM 1.14233612153051 0.115470127072109 no 408 0.126657166110751 729 6769040 SGTC_1363 1636-0063 10.4 µM 1.13765328251285 0.116333927596354 no 409 0.127632644116246 705 6072185 SGTC_2248 tofa 1.1 µM 1.13675531230482 0.116500090456592 no 410 0.127820294685929 627 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1054 3429-0080 167 µM 1.1365045470427 0.116546522799549 no 411 0.127872731817594 688 1162877 SGTC_3235 9132602 49.47 µM 1.12660891604878 0.118389311485236 no 412 0.129953933874105 711 4912240 SGTC_1766 st045414 44.774 µM 1.124949656455 0.118700308181743 no 413 0.130305184060321 728 253960 SGTC_1913 st060213 96.1 µM 1.12462842907758 0.118760582777578 no 414 0.130373260792664 723 688959 SGTC_467 ro 31-8220 72.8 µM 1.12107595766698 0.119428604870773 no 415 0.131127765782867 715 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_71 0417-1750 47.813 µM 1.11503482879693 0.120570684161848 no 416 0.13241774848535 734 6811472 SGTC_876 0720-0963 56.8 µM 1.11291021927179 0.120974164952472 no 417 0.132873495303313 741 765861 SGTC_378 3970-0959 8.33 µM 1.11117839642838 0.121303754419569 no 418 0.133245784150736 697 6615653 SGTC_67 0335-0847 266 µM 1.10743100814213 0.122019093552342 no 419 0.134053812836254 826 4552207 YOR254C SEC63 SGTC_1092 toremifene 6.32 µM 1.10726425516211 0.122050993740608 no 420 0.134089846933438 745 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2785 7756463 72.73 µM 1.09715246834332 0.12399635438231 no 421 0.136287373634136 682 2201551 SGTC_1375 2910-0797 186 µM 1.0939254912857 0.124621720502338 no 422 0.136993828847632 708 742508 SGTC_1032 k061-1018 98.7 µM 1.09294640757025 0.124811895418823 no 423 0.137208665404179 799 4005393 SGTC_175 3793-3120 23.7 µM 1.08891475283504 0.125597130909903 no 424 0.138095739935514 663 5322297 SGTC_199 4063-0024 41.6 µM 1.08515353811402 0.126332795519502 no 425 0.138926829198522 741 306215 SGTC_1324 1418-0026 34.4 µM 1.08206503844376 0.126939123296564 no 426 0.139611814718681 739 1372513 SGTC_1940 st075990 51.1 µM 1.07609437230415 0.128117007944195 no 427 0.140942526147472 797 1084979 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.07226008680397 0.128877421443072 no 428 0.141801614341236 794 91467 include heat shock SGTC_1486 3970-0793 4.53 µM 1.07125120363858 0.129078021784766 no 429 0.142028247033851 740 2844330 SGTC_1481 3346-2004 36 µM 1.07011410932666 0.129304374260912 no 430 0.14228397448607 755 2770522 SGTC_247 mechlorethamine 29.705 µM 1.06966249399359 0.129394350079075 no 431 0.142385627151714 687 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_289 k017-0060 526 µM 1.06942688564388 0.12944130780652 no 432 0.142438678985771 697 5512909 SGTC_1864 st057645 30.4 µM 1.0685663200037 0.12961292245238 no 433 0.142632565788363 716 688666 SGTC_153 4077-0274 519.67 µM 1.06250837633287 0.130825461827528 no 434 0.144002478697529 697 3121976 SGTC_3292 9120825 59.784 µM 1.06104746266526 0.131119043355783 no 435 0.144334165985605 763 24824900 SGTC_100 0086-0128 49.5915 µM 1.06078436804877 0.131171962508026 no 436 0.144393953921722 778 93297 SGTC_415 dibenzyl ketone 100 µM 1.06028869880606 0.131271702060058 no 437 0.144506639500714 760 7593 SGTC_2485 5633444 17.78 µM 1.05524300752308 0.132289986499807 no 438 0.145657099613731 720 5724239 SGTC_2026 5148700 152 µM 1.0548636818471 0.132366758675629 no 439 0.145743837244762 734 79838 SGTC_1722 st034304 3.6505 µM 1.05284216150044 0.132776414415329 no 440 0.146206669019021 751 4036148 YLR033W RSC58 SGTC_1719 st032227 49.2 µM 1.05282612829416 0.132779666988208 no 441 0.146210343800108 734 3125804 SGTC_2857 9024691 58.44 µM 1.05175842862381 0.13299638915059 no 442 0.146455198194354 709 16478292 SGTC_3269 9137823 49.47 µM 1.05044795289215 0.133262722804185 no 443 0.146756104223265 673 17682936 SGTC_2382 9035899 200 µM 1.05032468711855 0.133287793510288 no 444 0.146784429329047 771 6462679 SGTC_2596 sinensetin 100 µM 1.05021324972222 0.133310461266222 no 445 0.14681003956156 705 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_512 prima-1 270 µM 1.04842435518092 0.133674707770627 no 446 0.147221568622276 776 322968 A re-activator of the apoptotic function of mutant p53. SGTC_115 0527-0192 112.043 µM 1.04741134660397 0.133881275112247 no 447 0.147454950373704 846 4233931 SGTC_949 1165-0505 146 µM 1.04653189361484 0.134060786325013 no 448 0.147657763864907 810 6244267 SGTC_1643 st009866 20.2 µM 1.04525477288545 0.134321762564432 no 449 0.147952617309201 754 3156273 YOR207C RET1 SGTC_2670 beta-carotene 100 µM 1.04520350366467 0.134332246572935 no 450 0.147964462240982 689 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_477 mead ethanolamide 10 µM 1.04514578217305 0.134344050674407 no 451 0.147977798626134 603 16061185 SGTC_2692 st077426 47.7 µM 1.04056609387762 0.135282872146437 no 452 0.149038487128293 775 25238571 SGTC_1762 st045503 25.4615 µM 1.03815710671954 0.135778507658289 no 453 0.149598459188451 768 4645554 SGTC_3318 9139014 38.6185 µM 1.03415927095005 0.136603781393436 no 454 0.150530855597384 730 16643984 SGTC_1747 st037496 66.6 µM 1.03277363263425 0.13689061769875 no 455 0.150854922896982 782 723305 SGTC_2912 7964298 10.93 µM 1.03121658926371 0.137213426838403 no 456 0.151219631448451 811 2975850 SGTC_2098 5376439 882.5 nM 1.03111086051403 0.137235365557113 no 457 0.15124441769692 814 2844116 SGTC_3047 9092122 49.47 µM 1.02895499572355 0.137683230095689 no 458 0.151750411680482 737 17173831 SGTC_17 0960-0276 49.807 µM 1.02853613887944 0.137770360018377 no 459 0.151848850176458 792 6821114 SGTC_2000 st075254 36.4 µM 1.02835464094633 0.137808126605764 no 460 0.151891518455844 744 17234175 SGTC_2144 5628481 200 µM 1.0272311416654 0.138042064606943 no 461 0.152155818716455 743 2818399 SGTC_2714 st079313 56.9 µM 1.02681924324257 0.13812789900004 no 462 0.152252793197959 758 2939799 SGTC_2138 5575593 77.673 µM 1.02603884148238 0.138290624582585 no 463 0.152436638019924 745 762213 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.0258135815339 0.138337618986953 no 464 0.152489731505211 822 6708784 An antioxidant flavonoid SGTC_3246 9135460 32.98 µM 1.02336664728801 0.138848807093954 no 465 0.153067261407383 705 41446951 SGTC_3029 9088683 49.47 µM 1.02042776746398 0.13946446566082 no 466 0.153762815168576 759 25236615 SGTC_1900 st060200 72.8 µM 1.01997034296583 0.139560457110772 no 467 0.153871263109508 788 688945 SGTC_2176 5809774 33.9695 µM 1.01846852866495 0.139875931737869 no 468 0.154227674812375 819 2870539 SGTC_3202 9113761 49.47 µM 1.01843102744125 0.139883815530424 no 469 0.154236581612606 847 4798415 SGTC_2770 toltrazuril 17.5 µM 1.01612875262386 0.140368395717598 no 470 0.154784039341565 829 68591 Kills coccidiodes. SGTC_1151 3909-8316 15.3 µM 1.01534006855413 0.140534658864585 no 471 0.154971875313684 785 800431 SGTC_171 k064-0041 9.68 µM 1.0150503212337 0.140595774304223 no 472 0.1550409204237 681 53325 SGTC_1646 st011709 75.6 µM 1.01402255015092 0.140812704114041 no 473 0.155285996117596 747 5757843 SGTC_1763 st044482 94.5 µM 1.01379310335228 0.140861164032331 no 474 0.155340743421006 808 88505 SGTC_1824 st053723 68.6 µM 1.0118729790929 0.141267144092738 no 475 0.155799395198493 790 675225 SGTC_546 peri-Naphthalide 147 µM 1.01046885019587 0.14156452668798 no 476 0.156135358034493 785 223824 A penicillin ester. SGTC_2307 7538926 6.34 µM 1.00880816507757 0.141916792826643 no 477 0.156533322225559 799 96582 SGTC_305 1682-2595 20.8 µM 1.00776725597935 0.142137893814675 no 478 0.15678310438035 818 226033 SGTC_2493 resveratrol 26.09 µM 1.00718073170328 0.142262580913183 no 479 0.156923965382182 739 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2204 7233102 200 µM 1.00566089909551 0.142586020972188 no 480 0.157289359125331 754 2172480 SGTC_2553 4-methylesculetin 85.09 µM 1.00195901393272 0.143375909411135 no 481 0.158181694220348 812 5319502 SGTC_386 1509-0011 3.07 µM 1.00180887773799 0.143408006892859 no 482 0.158217954343198 873 3107280 SGTC_450 aminopyrene 156 nM 0.999744247965023 0.143849894336268 no 483 0.158717146350202 806 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1902 st060212 70.5 µM 0.999714353488496 0.143856299313931 no 484 0.158724381896473 809 688944 SGTC_2667 digitoxin 100 µM 0.99740089324508 0.144352548411598 no 485 0.159284978974311 755 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2072 5231554 129 µM 0.997114134125252 0.144414139988041 no 486 0.159354556579573 863 789545 SGTC_3049 9092223 49.47 µM 0.995845673616651 0.144686798772001 no 487 0.159662567307441 769 8623917 SGTC_2406 ethylparaben 405.7 µM 0.99541353567448 0.144779767045893 no 488 0.159767589024695 683 8434 A possible steroid mimic. SGTC_1734 st037168 69.4 µM 0.994233961506786 0.145033740229464 no 489 0.160054488845475 782 708907 SGTC_2044 5102272 200 µM 0.988583522758232 0.146254488911718 no 490 0.161433475600229 740 592666 SGTC_478 N-arachidonylglycine 10 µM 0.987857295550837 0.146411885590135 no 491 0.161611271204779 710 5283389 SGTC_936 3005-4620 401 µM 0.98525373305197 0.14697709527692 no 492 0.162249726428603 870 777207 SGTC_544 k015-0020 52.4 µM 0.984763066101548 0.147083778252389 no 493 0.162370233240524 796 3008304 SGTC_1038 k292-0204 154 µM 0.984081194449237 0.147232119990161 no 494 0.162537796248567 753 4454212 SGTC_1554 st069299 38.7 µM 0.983369449545484 0.14738706761506 no 495 0.162712820278344 804 24207999 SGTC_1204 4049-0315 18.3 µM 0.98254744328124 0.147566155186549 no 496 0.162915110989699 799 588402 SGTC_158 k038-0087 26.446 µM 0.981839149799458 0.147720585430666 no 497 0.163089548777342 886 X158 SGTC_1012 4112-3522 18 µM 0.981736578772885 0.14774295810705 no 498 0.163114819923133 843 3112398 SGTC_1513 0337-0559 19 µM 0.979864046350899 0.148151791593331 no 499 0.163576616213883 749 775073 SGTC_1306 1185-0270 9.02 µM 0.979624507152573 0.148204145192913 no 500 0.163635751577439 859 1548076 SGTC_141 0443-0274 32.331 µM 0.976219915965233 0.148949589594982 no 501 0.164477747918496 931 1627241 SGTC_1959 st077091 55.8 µM 0.974807914957028 0.149259484673028 no 502 0.164827775128814 855 821356 YKL052C ASK1 SGTC_2447 5741742 33.78 µM 0.974276861789531 0.149376147448459 no 503 0.164959545023085 836 1776504 SGTC_136 0097-0015 404.482 µM 0.97173095021897 0.149936283431064 no 504 0.165592207581973 909 4861337 SGTC_1974 st069448 26.9 µM 0.966092457222638 0.151181810731643 no 505 0.16699895925903 830 6323587 YNR016C ACC1 SGTC_1807 st050092 58.9 µM 0.963845346446328 0.151680103987068 no 506 0.167561734050059 802 5008496 SGTC_558 k064-0027 21.3 µM 0.956569178754548 0.153301064648237 no 507 0.169392375837312 866 5088526 SGTC_2192 5915882 198.485 µM 0.955463564602295 0.153548370516706 no 508 0.169671661199989 818 2876149 SGTC_2773 thioridazine 9.09 µM 0.954818181225554 0.153692853150622 no 509 0.169834825708167 888 5452 An antipsychotic. SGTC_883 0850-0245 24.6 µM 0.954315561327202 0.153805437503364 no 510 0.169961966710497 875 6823229 YPR165W RHO1 SGTC_2741 miltefosine 3.04 µM 0.952777478105337 0.15415029951867 no 511 0.170351413885787 751 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_588 3970-1144 52.9 µM 0.949415558210703 0.154905873393315 no 512 0.171204650257473 846 1888707 SGTC_2245 6637752 200 µM 0.949343624246595 0.154922066858975 no 513 0.17122293650353 770 681890 SGTC_2397 5161689 200 µM 0.948111634066584 0.155199580755427 no 514 0.171536313076716 867 2259942 SGTC_4 0960-0234 25.671 µM 0.945465267070477 0.155796801189586 no 515 0.172210697483638 823 6821112 SGTC_1873 rapamycin 2 nM 0.944676076736884 0.155975195118921 no 516 0.172412137107347 886 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1046 2001-0062 216 µM 0.944491432502931 0.156016952780289 no 517 0.17245928895268 831 739778 SGTC_2064 5220758 200 µM 0.939039142248671 0.157253319888991 no 518 0.173855324055095 890 788518 SGTC_2294 7971431 200 µM 0.938587380470582 0.157356050068566 no 519 0.173971317223604 772 5741572 SGTC_404 fumagillin 50 µM 0.93739652435314 0.157627060936988 no 520 0.174277314059645 888 12015870 A methionine aminopeptidase binder. SGTC_1690 st023502 41.2 µM 0.93729466764762 0.157650255357577 no 521 0.174303502551217 847 24207482 SGTC_2025 5147754 141 µM 0.935872179755883 0.157974413183126 no 522 0.174669501278369 869 315777 YLR208W SEC13 SGTC_3156 9099931 49.47 µM 0.93534542981089 0.158094560385681 no 523 0.174805155002924 919 18111053 SGTC_2460 5552655 174.22 µM 0.933094705293368 0.158608607099659 no 524 0.175385536315954 839 5401989 SGTC_2387 9077560 195.08 µM 0.932391813375482 0.158769366090723 no 525 0.175567037033311 851 5303272 SGTC_1198 1612-1005 86.7 µM 0.931251581303978 0.159030376604323 no 526 0.175861720773471 903 6998509 SGTC_2114 5491910 81.25 µM 0.931002873790627 0.159087345566738 no 527 0.175926038808235 878 2849228 SGTC_2022 5136654 200 µM 0.928789358215492 0.159594962551546 no 528 0.17649913027651 843 1713771 SGTC_2671 danthron 100 µM 0.926651379818453 0.160086262184154 no 529 0.177053784492852 867 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2244 6635614 200 µM 0.926515521327073 0.16011751535018 no 530 0.177089067337579 736 836499 SGTC_2320 7373003 200 µM 0.926071517568 0.160219682705494 no 531 0.177204407379578 874 5415828 SGTC_1735 st034310 56.75 µM 0.92166151103502 0.161236758958334 no 532 0.17835258137554 863 871153 SGTC_2256 7954252 200 µM 0.921521878393628 0.161269030963219 no 533 0.178389012039068 763 2972920 SGTC_2269 7935389 174.42 µM 0.918726488457292 0.161915990114676 no 534 0.179119325651793 844 97605 SGTC_2926 9010726 65.15 µM 0.918687005154457 0.16192514014013 no 535 0.179129654371054 865 2994293 SGTC_822 1487-0950 154 µM 0.915148781942503 0.162746470354467 no 536 0.180056764291031 899 1958375 SGTC_579 4491-1009 110 µM 0.911792028140106 0.163528176231653 no 537 0.180939103836695 1094 1271041 SGTC_3293 9120939 62.045 µM 0.91172387109827 0.163544073555281 no 538 0.180957047278133 875 934087 SGTC_531 3788-1495 174 µM 0.905308422969456 0.165044940516606 no 539 0.182651007687209 848 2896655 SGTC_280 3448-3607 3.04 µM 0.904622111679772 0.165206026506805 no 540 0.182832808507823 928 626179 SGTC_1803 st050068 52.4 µM 0.903177063304476 0.165545530310641 no 541 0.183215964538278 1031 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1002 4049-0206 172 µM 0.901762735123635 0.165878253276065 no 542 0.183591459632067 927 4662749 SGTC_2915 7971052 15.16 µM 0.899485190601787 0.166414957057415 no 543 0.184197140267087 758 5741558 SGTC_29 0299-0004 12.984 µM 0.89852356689228 0.166641900117228 no 544 0.184453243404199 821 16871 A napthoquinone isolated from Swertia calycina. SGTC_3349 9149703 23.001 µM 0.898370762965989 0.166677980204165 no 545 0.184493959088608 937 4910494 SGTC_3050 9093513 49.47 µM 0.896084249590116 0.167218474124585 no 546 0.185103884222508 933 25236664 SGTC_82 0054-0107 293.755 µM 0.895479753624921 0.167361555585973 no 547 0.185265342015048 934 3104697 SGTC_3062 9077494 49.47 µM 0.895187085937038 0.167430857041608 no 548 0.185343543473222 888 16459633 SGTC_1816 st051957 91.6 µM 0.894834162389619 0.167514451209852 no 549 0.185437872684471 935 674121 SGTC_2747 doxorubicin 7.63 µM 0.892705711714003 0.168019170178646 no 550 0.18600739541221 743 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2846 9008642 19.48 µM 0.892156428370992 0.168149580308849 no 551 0.186154546412543 853 2992898 SGTC_325 2810-4341 181 µM 0.8919931882296 0.168188349118745 no 552 0.186198291753358 925 774970 SGTC_2489 cantharidin 73.42 µM 0.890592365241156 0.168521274756759 no 553 0.186573948280715 908 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1414 3917-0015 5.4 µM 0.889961635562074 0.168671314935502 no 554 0.186743243197631 935 6618702 SGTC_837 0091-0265 12.5 µM 0.888968837162145 0.168907659166751 no 555 0.187009913981152 936 759367 SGTC_2792 7535235 81.82 µM 0.888846183100562 0.168936872783695 no 556 0.187042875839035 844 1281891 SGTC_1243 0416-0003 5.65 µM 0.885203948082812 0.169805855557875 no 557 0.188023321675645 895 2141977 SGTC_98 0074-0023 107.663 µM 0.883969914222176 0.170100926516906 no 558 0.188356226979735 966 3563821 SGTC_1190 1486-1332 13 µM 0.883956160315825 0.170104217076508 no 559 0.18835993941855 927 4150046 SGTC_890 0929-0006 47.2 µM 0.882453626883883 0.170463937014851 no 560 0.188765773301713 900 1378169 SGTC_889 0919-1524 82.7 µM 0.880414615217329 0.170952873144891 no 561 0.18931737094066 889 3905452 SGTC_2502 avocadyne acetate 18.59 µM 0.877773967637049 0.171587407953265 no 562 0.190033197194871 1025 3952079 SGTC_578 3460-0051 92 µM 0.874497068863693 0.172376920397326 no 563 0.190923807886544 1042 2876744 SGTC_550 4123-0385 25.7 µM 0.873926085485333 0.17251472572965 no 564 0.19107925392041 928 5731123 SGTC_2864 9034755 47.6 µM 0.873288550329867 0.17266867615079 no 565 0.191252909864895 991 4930451 SGTC_914 3820-6779 408 µM 0.873126744367921 0.172707762587682 no 566 0.191296999006077 952 2893481 SGTC_1059 3448-6867 171 µM 0.872850389770394 0.172774532851791 no 567 0.191372314943266 965 3934407 SGTC_370 0180-0345 38.7 µM 0.872151896491377 0.172943369731243 no 568 0.191562758887674 865 3989527 SGTC_640 3381-0960 37.1 µM 0.870330637612395 0.173384091033935 no 569 0.192059870211939 1008 1745025 SGTC_3154 9100113 49.47 µM 0.869023114082394 0.17370093546504 no 570 0.192417244160028 941 25237525 SGTC_1637 st007924 17.4 µM 0.868986398414522 0.173709837868985 no 571 0.192427285197221 904 683336 SGTC_1989 st071868 50.2 µM 0.86868440224156 0.173783073530851 no 572 0.192509887564066 985 16414057 SGTC_993 3909-8757 62.7 µM 0.867373020728629 0.174101318210155 no 573 0.192868829622262 867 4288324 YLR208W SEC13 SGTC_2349 9023730 187.07 µM 0.864580836676068 0.174780155696031 no 574 0.193634447160835 947 4126287 SGTC_2677 mitomycin C 100 µM 0.861123588718534 0.175623008623051 no 575 0.194584989336137 940 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_65 0798-0905 34.986 µM 0.860699555539578 0.175726561983065 no 576 0.194701768983335 1009 3602145 SGTC_790 1575-0012 79.1 µM 0.859802929753588 0.175945654771047 no 577 0.194948842010361 1002 378741 YLR208W SEC13 SGTC_800 3448-7362 155 µM 0.859510913413004 0.17601704703115 no 578 0.195029350787886 1118 15991913 SGTC_2281 7943571 200 µM 0.857802751624028 0.176435026398567 no 579 0.195500695053046 1045 1244024 SGTC_1768 st044301 37.178 µM 0.857556202017011 0.176495407770812 no 580 0.195568784187144 1008 3931349 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.85630722302445 0.176801490469511 no 581 0.195913933515826 948 140250 A respiratory chain inhibitor. SGTC_2370 9071495 200 µM 0.85473989860224 0.177186063329285 no 582 0.196347578596336 902 21791103 SGTC_142 0335-0849 62.6745 µM 0.854419268432641 0.177264801090765 no 583 0.19643636172795 1014 3889043 YPR107C YTH1 SGTC_2474 5321570 43.32 µM 0.8541346300427 0.177334718794252 no 584 0.19651519904728 964 2841384 SGTC_665 3914-0008 307 µM 0.853450485329341 0.177502841221604 no 585 0.196704767475895 954 1069549 SGTC_1692 fluoroquinolonic acid 71 µM 0.852565404331538 0.177720491153148 no 586 0.196950177246057 959 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_140 0062-0056 502.533 µM 0.851481991548673 0.177987141872324 no 587 0.19725083139114 1041 3758964 SGTC_1449 4112-4002 201 µM 0.849085776943021 0.178577796252148 no 588 0.197916782050095 905 2059539 SGTC_2786 7743617 45.45 µM 0.848332036794035 0.1787638441909 no 589 0.198126540312131 875 583674 SGTC_288 1315-0019 35.1 µM 0.846769479477183 0.17914992341916 no 590 0.198561811543887 990 6811474 SGTC_742 0kpi-0133 140 µM 0.844695842774971 0.179663090202283 no 591 0.19914034058986 1004 2728852 SGTC_984 1492-0255 2.91 µM 0.844394658142009 0.17973770167761 no 592 0.199224453208661 939 1585198 SGTC_1174 0739-0097 51.1 µM 0.843092197804573 0.180060579947507 no 593 0.199588440983828 976 728447 SGTC_2482 5981709 142.65 µM 0.841975442604308 0.18033771193267 no 594 0.199900849740987 965 877755 SGTC_615 k087-0205 167 µM 0.841380866648994 0.180485369966001 no 595 0.20006730039211 953 9642773 SGTC_2071 5230951 39.92 µM 0.837819544847985 0.181371381621198 no 596 0.201066030026195 1067 1799272 SGTC_581 0958-0271 211 µM 0.83632679712761 0.181743566881345 no 597 0.201485540922681 1057 4591145 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.835337494740457 0.181990491705778 no 598 0.201763855988353 1002 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2565 isoliquiritigenin 100 µM 0.834931780976415 0.182091816415942 no 599 0.201878059772103 838 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1349 flufenamic acid 69 µM 0.833615802917654 0.182420717125475 no 600 0.20224875880599 947 3371 A non-steroidal anti-inflammatory. SGTC_3288 9119690 36.221 µM 0.832766143020201 0.182633268573339 no 601 0.202488316434418 924 17595618 YKL019W RAM2 SGTC_3287 9117173 37.0625 µM 0.832398268927007 0.182725344139889 no 602 0.20259208941579 989 2789709 SGTC_2290 7904846 200 µM 0.83055882272567 0.183186175559627 no 603 0.203111452366094 980 2962154 SGTC_1964 st076914 61 µM 0.829987504698848 0.183329453709494 no 604 0.203272924199073 1041 24208661 SGTC_169 k015-0017 16.025 µM 0.829593477377843 0.183428310663146 no 605 0.20338433291728 962 1840002 SGTC_2728 chlorpromazine 9.18 µM 0.829198368480516 0.183527472333323 no 606 0.203496084017925 947 2726 A thorazine and dopamine antagonist. SGTC_577 r071-0003 38.6 µM 0.82770697251882 0.183902073467084 no 607 0.203918234723068 1116 4568517 YMR134W ERG29 SGTC_3194 9111903 49.47 µM 0.826368060592225 0.184238779774435 no 608 0.204297667894252 984 17087251 SGTC_1746 st038117 42 µM 0.82470264713112 0.18465812889658 no 609 0.204770214234312 971 2898218 SGTC_1489 4065-0444 182 µM 0.823254606295579 0.185023225778105 no 610 0.205181610880089 999 2877968 SGTC_3278 9139605 49.47 µM 0.822474018770161 0.185220222484853 no 611 0.205403583822638 970 7958859 SGTC_1906 st060206 94.7 µM 0.821699804193324 0.18541573946602 no 612 0.205623885326433 1047 5133468 SGTC_2781 5567276 71.43 µM 0.818014799455933 0.186348090531238 no 613 0.206674368364728 986 2853274 SGTC_527 4476-4215 268 µM 0.81772373739624 0.186421856337991 no 614 0.206757476525684 990 4418754 SGTC_3206 9114350 49.47 µM 0.814680271654704 0.187194265235528 no 615 0.207627674439972 930 17087243 SGTC_3175 9106517 49.47 µM 0.812782276728408 0.187676962661057 no 616 0.208171449369505 993 41468073 SGTC_433 pimozide 108 µM 0.812516444309982 0.187744630407651 no 617 0.208247677310754 982 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_507 nimesulide 162 µM 0.809395394600264 0.188540221546125 no 618 0.209143875198847 1020 4495 A COX2 inhibitor. SGTC_1809 st050081 57.6 µM 0.809174226974007 0.188596678461745 no 619 0.209207468708615 1033 5036894 SGTC_31 0508-1974 57.237 µM 0.809148220041229 0.188603317872275 no 620 0.209214947368915 1004 6810525 SGTC_730 1436-0052 41.2 µM 0.807880214981818 0.188927206568226 no 621 0.209579770968772 1030 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_470 aa-861 153 µM 0.807564347423138 0.189007942441328 no 622 0.209670708866519 1042 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.805736958728765 0.189475440734036 no 623 0.210197267170346 1063 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_324 1315-0088 19.6 µM 0.804184162294006 0.189873249170145 no 624 0.210645312054519 985 6787421 SGTC_3188 9110789 49.47 µM 0.802251464125511 0.190369100764407 no 625 0.211203756031781 1028 849217 SGTC_3321 9137793 26.8275 µM 0.800753623361445 0.190753932159293 no 626 0.21163714608097 1062 4904192 SGTC_1645 Cervolide 78 µM 0.799761414300811 0.191009117249125 no 627 0.211924521440886 984 23173 A fragrance. SGTC_1091 telmisartan 47.6 µM 0.79951175662268 0.191073359370279 no 628 0.211996866186327 1096 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1290 0986-0249 10.2 µM 0.798861808764218 0.191240666630786 no 629 0.212185273059925 1039 53329 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.796769218448269 0.191779943515808 no 630 0.212792537633428 1077 688788 SGTC_2059 5238311 157 µM 0.795244125348944 0.192173557906188 no 631 0.213235754351654 1023 703021 SGTC_913 3487-1245 167 µM 0.793975402584071 0.192501381451091 no 632 0.213604875564438 1020 4016153 SGTC_2982 9019404 25.97 µM 0.788938478325205 0.193806234887651 no 633 0.215073982452872 982 22333232 SGTC_2919 7978188 46.38 µM 0.786604547192091 0.19441268104663 no 634 0.215756698281155 1070 2980291 SGTC_773 4358-1457 44.6 µM 0.786103780212723 0.194542950166418 no 635 0.215903344924939 1109 1186886 SGTC_2276 7947513 42.08 µM 0.783460802327615 0.1952313719865 no 636 0.216678281571683 1009 2105100 SGTC_655 k060-0012 42 µM 0.782882189518013 0.195382281722101 no 637 0.216848148642812 1055 5994525 SGTC_2911 7942208 15.64 µM 0.781554706369935 0.195728774245231 no 638 0.21723815718686 1039 1243384 SGTC_522 1273-0010 11.6 µM 0.777522198449807 0.196783603011554 no 639 0.218425371437199 1078 5705015 SGTC_2048 5246248 200 µM 0.776224969191813 0.197123664462389 no 640 0.218808082800822 1070 677046 SGTC_16 erodoxin 22.806 µM 0.775449376855494 0.197327151446349 no 641 0.21903708390829 1118 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_782 0083-0095 30.5 µM 0.76840651255387 0.199180749678489 no 642 0.221122856228663 1127 3591729 An indicator and reagent. SGTC_2060 5238662 140 µM 0.767561423007679 0.1994038697971 no 643 0.221373894238372 1035 790130 SGTC_1271 0832-2808 169 µM 0.767364847109948 0.199455791230654 no 644 0.221432311430895 1110 3663794 SGTC_1572 epiandrosterone 68.9 µM 0.766831306452592 0.199596755910217 no 645 0.221590910114454 1072 441302 A steroid. SGTC_2140 5586273 200 µM 0.765362070144737 0.199985246807035 no 646 0.2220279862434 1111 854421 SGTC_3128 9127691 49.47 µM 0.76506763203359 0.200063155866777 no 647 0.222115636401334 983 41316314 SGTC_1478 0453-0656 35.7 µM 0.762107984198876 0.200847299102683 no 648 0.222997778991462 1122 5258496 SGTC_582 0987-0078 156 µM 0.7619365757825 0.200892769297357 no 649 0.223048929457183 1181 1625765 SGTC_306 1672-3436 11.6 µM 0.761869246134487 0.200910631791297 no 650 0.223069023313623 1118 6797378 SGTC_1767 st044992 70.3 µM 0.761211663014586 0.201085138089239 no 651 0.223265326572256 1103 9600693 SGTC_2595 hexamethylquercetagetin 100 µM 0.756998622363267 0.20220533029018 no 652 0.224525343904397 1035 386331 SGTC_2795 7780010 54.55 µM 0.755498363602577 0.202605129075426 no 653 0.224975006904891 1057 953673 SGTC_2390 9097792 176.6 µM 0.749914488440683 0.204097303263788 no 654 0.226653103933991 1059 4497149 SGTC_1911 st060208 74.3 µM 0.749054783123872 0.204327621721486 no 655 0.226912093433727 1116 688783 SGTC_2908 7930301 100 µM 0.748585880986158 0.204453307649639 no 656 0.227053422306148 1112 2223178 SGTC_13 0199-0087 65 µM 0.748158404258968 0.204567929874609 no 657 0.227182308639496 1139 4589825 SGTC_834 0312-0008 75.7 µM 0.747355223758006 0.204783395479311 no 658 0.22742458299888 1127 6385573 YIL048W NEO1 SGTC_1331 1472-0049 76.2 µM 0.745847678031153 0.205188182202033 no 659 0.227879717427436 1106 24051409 SGTC_1460 k062-0059 9.15 µM 0.744838597765408 0.205459392834145 no 660 0.228184649127806 1106 1373085 SGTC_326 k292-0812 17.5 µM 0.742505864645534 0.206087176102849 no 661 0.228890449927069 1111 3579357 SGTC_3167 9103034 49.47 µM 0.74220198821067 0.206169038737707 no 662 0.228982482074402 1141 5127859 SGTC_3275 9138069 49.47 µM 0.741500855594791 0.206357993535538 no 663 0.229194906597879 1119 17617007 SGTC_366 0181-0206 4.31 µM 0.740752560558384 0.206559771744356 no 664 0.229421741940522 1132 274874 SGTC_943 3253-1379 105 µM 0.740661287681642 0.206584391524814 no 665 0.229449418664157 1093 668464 SGTC_3096 9117468 49.47 µM 0.740161278552263 0.206719293918572 no 666 0.229601069900244 1041 41316311 SGTC_1474 0330-0125 5.35 µM 0.739110381579742 0.207002995737964 no 667 0.229919986684202 1144 X1474 SGTC_911 3456-4043 236 µM 0.738843711084975 0.207075023160539 no 668 0.23000095287923 1161 914281 SGTC_468 gf-109203x 121 µM 0.738710089648428 0.207111119746637 no 669 0.230041528869281 1050 2396 A protein kinase C inhibitor. SGTC_2486 5283202 22.39 µM 0.737150816332271 0.207532617989844 no 670 0.230515319687573 1096 1377751 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.736938672003207 0.20759000338253 no 671 0.230579822629175 1088 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_391 gliotoxin 8.33 µM 0.734801817745441 0.208168548692347 no 672 0.231230099953337 1149 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1398 3558-0053 112 µM 0.734514347701674 0.208246452680312 no 673 0.231317659480735 1061 4532369 SGTC_2337 9009472 200 µM 0.734285978418742 0.208308352701602 no 674 0.231387230886536 1129 5742383 SGTC_2726 cimetidine 79.27 µM 0.732620570511103 0.208760093462589 no 675 0.231894940634732 1146 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2619 obliquin 87.91 µM 0.730361057509308 0.20937390690271 no 676 0.232584757773037 1147 6708593 A bioactive alkalod. YER133W GLC7 SGTC_357 1325-0123 420 µM 0.72940636227897 0.209633575774824 no 677 0.232876563567364 1126 1098503 SGTC_1876 myriocin 605 nM 0.729179028643858 0.20969543647165 no 678 0.232946078823735 1156 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_988 1497-1057 103 µM 0.72767926771317 0.210103811544591 no 679 0.233404972208414 1139 3533044 SGTC_1935 st074532 41.6 µM 0.725308827918308 0.21075021867897 no 680 0.234131295586381 1222 2829742 SGTC_841 0251-0215 91.2 µM 0.724809449797991 0.210886545220175 no 681 0.234284468838784 1176 3888614 SGTC_236 1509-0011 5.31 µM 0.7223326204085 0.211563465217286 no 682 0.235045000979051 1252 3107280 SGTC_2945 9067681 61.76 µM 0.721830573879058 0.211700829940054 no 683 0.235199324834048 1219 16456930 SGTC_106 0092-0003 11.579 µM 0.721502354511449 0.211790662103088 no 684 0.235300246275864 1102 1072148 SGTC_1315 1237-0019 3.69 µM 0.721460306062188 0.21180217218589 no 685 0.235313177130905 1152 825140 SGTC_2855 9016525 58.44 µM 0.718935959570552 0.212493841516929 no 686 0.23609018941257 1201 43811474 SGTC_3200 9114385 49.47 µM 0.71872999905148 0.212550332728612 no 687 0.23615364787363 1154 17018030 YLR208W SEC13 SGTC_2252 omeprazole 400 µM 0.716435537018469 0.213180254736472 no 688 0.236861229172262 1091 4594 A proton pump inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.716356811582975 0.213201887333443 no 689 0.236885527706429 1271 5282309 SGTC_271 rotenone 740 µM 0.716195740515465 0.213246151293339 no 690 0.236935246415143 1214 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_440 fluspirilene 35.1 µM 0.715995763803257 0.2133011143744 no 691 0.236996982328374 1183 3396 An atypical antipsychotic. SGTC_2597 laccaic acid a 100 µM 0.715849618487825 0.21334128725897 no 692 0.23704210524535 1134 5491415 A textile dye. SGTC_2591 skatole 100 µM 0.714474099928177 0.213719610212742 no 693 0.237467033039827 1183 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2520 obtusaquinone 4.71 µM 0.714199842858061 0.213795088640904 no 694 0.237551807022664 1217 5967872 SGTC_1044 1222-0021 1.78 µM 0.713439856005055 0.214004326104732 no 695 0.237786808829017 1115 4306703 SGTC_1778 st046819 58.9 µM 0.712123640234623 0.214366984808264 no 696 0.238194108244194 1224 671715 SGTC_1850 st056238 17 µM 0.712069351952145 0.214381950602979 no 697 0.238210915810631 1190 5393177 SGTC_956 1185-0240 191 µM 0.711931126841577 0.21442005822855 no 698 0.238253713019542 1167 1416193 SGTC_2139 5578692 56.4705 µM 0.711692125420832 0.214485958419383 no 699 0.238327722490174 1126 650991 YMR113W FOL3 SGTC_1936 st074407 74.3 µM 0.711209324276207 0.21461911775908 no 700 0.238477265681318 1207 809813 SGTC_1511 0906-3109 28.5 µM 0.710030983187512 0.214944312698867 no 701 0.238842461539706 1234 2882180 SGTC_308 4092-1169 104 µM 0.707960427541861 0.215516430966276 no 702 0.239484916170634 1161 2268590 YDL196W YDL196W SGTC_3244 9134489 49.47 µM 0.70717298729133 0.215734241337756 no 703 0.239729491565943 1164 16584271 SGTC_1163 k060-0048 49.9 µM 0.707027580443601 0.215774475636691 no 704 0.239774669180925 1193 6809982 SGTC_658 3253-0951 102 µM 0.706791369682173 0.215839844789257 no 705 0.239848069290323 1192 1184878 SGTC_2006 4011487 200 µM 0.705462120402968 0.216207916237816 no 706 0.240261348554946 1201 45595294 SGTC_1222 0366-0074 1.18 µM 0.703950386279512 0.216626959436348 no 707 0.240731835712865 1202 286520 SGTC_1469 k284-2957 126 µM 0.699944460638029 0.21773964599774 no 708 0.241980994944415 1217 23884841 SGTC_1027 k015-0025 8.67 µM 0.69824767233642 0.218211938448967 no 709 0.242511158873677 1185 3598955 SGTC_2446 5162541 200 µM 0.697592387100352 0.218394491675092 no 710 0.24271607195372 1148 1549321 SGTC_731 3966-0296 387 µM 0.696555257000086 0.218683601209742 no 711 0.243040582535703 1231 660956 SGTC_2767 sibutramine 71.45 µM 0.696113969387463 0.218806680956777 no 712 0.243178729401138 1229 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1079 idarubicin 2.36 µM 0.695882103439864 0.218871366774015 no 713 0.243251332980629 1171 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2202 7226349 200 µM 0.695046460506902 0.219104585173189 no 714 0.243513092855709 1168 844334 SGTC_3072 9116419 49.47 µM 0.694516866811328 0.219252462669971 no 715 0.243679063475104 1176 17170162 SGTC_1905 st060207 84.5 µM 0.694463092917328 0.219267481065365 no 716 0.243695919217748 1150 1948547 SGTC_181 1447-1644 8.07 µM 0.691999443970396 0.219956182122809 no 717 0.244468839087108 1167 534600 SGTC_107 0358-0022 2.6945 µM 0.69095519066395 0.220248472190694 no 718 0.244796850489972 1154 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2775 cyproheptadine 69.59 µM 0.689768753773858 0.220580830035513 no 719 0.245169810608927 1224 2913 A selective serotonin reuptake inhibitor. SGTC_2831 7999036 19.48 µM 0.689102905592162 0.22076748061719 no 720 0.24537925583713 1201 2988270 SGTC_3026 9090633 49.47 µM 0.688718534375207 0.220875268731309 no 721 0.245500205115411 1204 25236842 SGTC_2827 7993847 71.43 µM 0.68360277389669 0.222312732967927 no 722 0.247113016298137 1165 2985692 SGTC_3021 9087658 49.47 µM 0.68266997205595 0.222575412647233 no 723 0.247407704125692 1202 25237042 SGTC_629 3448-6466 76.7 µM 0.681427033883387 0.222925702444388 no 724 0.247800660933466 1222 573744 SGTC_149 3970-0822 46.1 µM 0.681313438022189 0.222957732137882 no 725 0.247836591049831 1262 3114250 YBL034C STU1 SGTC_155 k072-0202 43.6 µM 0.680592712937247 0.223161010145005 no 726 0.248064619562652 1164 5857737 SGTC_359 0081-0058 15.9 µM 0.680541468524334 0.223175467470388 no 727 0.248080836922759 1301 3494159 SGTC_1525 8-methoxypsoralen 92.5 µM 0.680085323670274 0.223304180791197 no 728 0.248225218368364 1259 4114 Related to psoralen; DNA damaging agent. SGTC_2603 homopterocarpin 100 µM 0.679697541492196 0.223413636993546 no 729 0.248347996518409 1233 101795 A weak amylase inhibitor. SGTC_965 1291-5240 308 µM 0.676382922842082 0.224350472827398 no 730 0.249398778383622 1218 2834598 SGTC_372 0155-0182 15.9 µM 0.675693774870528 0.224545531585746 no 731 0.249617544575437 1223 771486 SGTC_625 k213-0058 121 µM 0.675350141116129 0.224642830778902 no 732 0.249726667274546 1286 3655420 SGTC_1172 0370-0043 85 µM 0.675208898936392 0.22468283014652 no 733 0.249771526813655 1255 376585 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.67471507543561 0.224822711248445 no 734 0.249928402359076 1222 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2271 7849410 118.62 µM 0.673420755648333 0.225189576203116 no 735 0.250339823855063 1221 972430 SGTC_2201 6605497 169.863 µM 0.672492369405411 0.22545292883677 no 736 0.250635148143635 1225 670741 SGTC_3247 9135149 49.47 µM 0.671806324735589 0.225647649107038 no 737 0.250853500883004 1203 8934436 YOR116C RPO31 SGTC_1743 st037606 46.3785 µM 0.67171567712913 0.22567338476045 no 738 0.250882359527329 1258 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3112 9123419 49.47 µM 0.671295831624228 0.225792604250816 no 739 0.251016044792758 1272 17015854 SGTC_2903 5923464 63.88 µM 0.671049825915543 0.225862476674515 no 740 0.251094394303485 1265 2876576 SGTC_2388 9080168 200 µM 0.669214096656246 0.226384260441905 no 741 0.251679457614141 1203 15943073 SGTC_480 am 92016 50 µM 0.668764678793928 0.226512105673743 no 742 0.251822800729976 1169 2129 K+ channel blocker. SGTC_458 nppb 133 µM 0.668224519858309 0.22666581780811 no 743 0.251995142987139 1279 4549 A chloride channel blocker. SGTC_980 1473-0395 201 µM 0.668027145698137 0.226721998928371 no 744 0.252058132397281 1192 768876 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.667188677944024 0.226960750254239 no 745 0.252325811105794 1202 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2867 9039098 71.43 µM 0.667000563846384 0.227014334679904 no 746 0.252385886631382 1220 6463460 SGTC_1866 st057638 64 µM 0.666513826986671 0.227153015101246 no 747 0.252541364365188 1238 688802 SGTC_1670 st016595 4.04 µM 0.664612510920573 0.227695192921612 no 748 0.25314918255583 1240 597879 SGTC_1562 morin hydrate 59.1 µM 0.659966690752873 0.229023051314592 no 749 0.254637602520549 1274 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_435 c-PAF 6.7 µM 0.659503383580625 0.229155710593634 no 750 0.254786287015179 1218 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1842 st055362 61.2 µM 0.657426596981576 0.22975088856288 no 751 0.255453327250614 1246 676032 SGTC_621 3584-0052 32.1 µM 0.654839346861848 0.230493567708701 no 752 0.256285597269719 1270 2273927 SGTC_766 1391-0721 126 µM 0.65475467936324 0.230517894462294 no 753 0.256312857086547 1274 1020919 YIL115C NUP159 SGTC_2243 6634756 200 µM 0.654031172404272 0.230725831746654 no 754 0.256545861307272 1312 885676 SGTC_1518 st038567 90.8 µM 0.653010026513553 0.231019489247758 no 755 0.2568749073054 1258 77966 SGTC_1977 st070720 65.3 µM 0.650590609458996 0.231716088626224 no 756 0.257655396895849 1259 682188 SGTC_2472 5377652 49.4 µM 0.650533916310979 0.231732425758317 no 757 0.257673700522081 1258 1610903 SGTC_343 4130-2827 29.8 µM 0.649667409672133 0.231982204804128 no 758 0.25795353989867 1276 1118244 SGTC_3005 9076496 71.4286 µM 0.648235341658319 0.232395340889444 no 759 0.25841637336962 1278 21368410 SGTC_491 tetrandrine 80.3 µM 0.647620094442821 0.232572958636163 no 760 0.25861534862202 1291 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_167 3672-0051 66.205 µM 0.647289288003043 0.232668491429306 no 761 0.25872236652155 1229 3237971 SGTC_322 k048-0136 19.3 µM 0.646925545252244 0.232773560992943 no 762 0.258840065972388 1271 6823282 SGTC_1367 1812-0510 76.9 µM 0.64554758985806 0.233171831799784 no 763 0.259286194304673 1267 1142582 YDR527W RBA50 SGTC_1563 conessine 56.1 µM 0.645400484482348 0.233214372040666 no 764 0.259333844764087 1342 441082 An anti-amoebic, histamine inhibitor. SGTC_525 k781-2675 26.7 µM 0.64436373789047 0.233514302725201 no 765 0.259669796593142 1315 3651118 YDL195W SEC31 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.64134753057662 0.234388106599793 no 766 0.260648457314296 1303 165521 SGTC_2145 5634607 200 µM 0.641162140762658 0.234441873519119 no 767 0.26070867212184 1241 308662 SGTC_1476 4112-3294 3.34 µM 0.640779062207047 0.234552995920138 no 768 0.26083311911673 1321 704369 SGTC_200 k038-0079 37.545 µM 0.637911817179053 0.235385643098388 no 769 0.261765542416443 1271 3436683 SGTC_2302 7771753 200 µM 0.637264942916792 0.235573720509541 no 770 0.261976141009965 1261 2203047 SGTC_2174 5790901 200 µM 0.637024552600257 0.235643634641166 no 771 0.262054425435201 1289 786020 SGTC_1127 asiatic acid 681.4 nM 0.636785688134119 0.235713116335183 no 772 0.26213222483395 1273 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_700 3453-2283 142 µM 0.63661718778234 0.235762137075794 no 773 0.262187113393682 1348 565664 SGTC_585 0kpi-0023 191 µM 0.636479187944585 0.235802288681754 no 774 0.262232070874754 1264 64601 SGTC_365 0121-0052 13.6 µM 0.635884002142019 0.235975503564207 no 775 0.262426015285817 1294 3101739 SGTC_1878 temozolomide 1 mM 0.63568435278242 0.236033622534303 no 776 0.26249108852105 1258 5394 DNA alkylating agent. SGTC_2178 5812956 200 µM 0.633472137423017 0.236678137571084 no 777 0.263212685143362 1279 5403383 SGTC_1080 nisoldipine 24.4 µM 0.633336491577451 0.236717688610876 no 778 0.263256964047808 1268 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3056 9094900 49.47 µM 0.631113440283366 0.237366394185414 no 779 0.263983176878709 1225 25236784 SGTC_2643 anethole 100 µM 0.630999554335489 0.237399653352704 no 780 0.264020407918095 1277 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2470 5664817 21.68 µM 0.630461512599397 0.237556817252894 no 781 0.264196338076694 1323 2859561 SGTC_2134 5324836 1.464 µM 0.6292866530116 0.237900196296058 no 782 0.264580703864541 1301 699272 SGTC_925 2064-1272 59.6 µM 0.629053995471371 0.237968227945159 no 783 0.264656853584734 1274 6815817 SGTC_1137 ixabepilone 100 µM 0.628199352476491 0.238218226574605 no 784 0.264936677220559 1301 154225 A novel microtubule stabilizer. SGTC_2083 5306046 65.942 µM 0.627834001386065 0.238325142304252 no 785 0.265056344805455 1307 539837 SGTC_38 0929-0051 58.268 µM 0.626225260178966 0.238796234130377 no 786 0.265583600497825 1314 1379719 SGTC_2328 6201408 200 µM 0.625849006358015 0.238906486958376 no 787 0.265706992239801 1276 2890418 SGTC_2776 terbinafine 19.92 µM 0.625476243186111 0.239015744374794 no 788 0.265829267886265 1300 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_720 r052-1644 49.9 µM 0.624911213926361 0.23918140732682 no 789 0.266014665980997 1280 1422863 YOR257W CDC31 SGTC_3164 9100705 49.47 µM 0.624276756674201 0.239367500880597 no 790 0.266222922908483 1337 17174235 SGTC_1246 0422-0085 105 µM 0.62373220822937 0.239527286200822 no 791 0.266401733584787 1298 264295 SGTC_2336 9001819 198.65 µM 0.622497059401678 0.239889928194177 no 792 0.266807538384267 1397 2989602 SGTC_2356 9061756 188.97 µM 0.621152627926367 0.240284995915494 no 793 0.267249602469261 1304 20104043 SGTC_1978 st071761 42 µM 0.620396111726988 0.240507457644529 no 794 0.267498515855522 1275 5147680 SGTC_122 0236-0016 402.397 µM 0.61913177844509 0.240879498665457 no 795 0.267914774981072 1343 6808838 SGTC_2843 9000894 45.46 µM 0.618617469184912 0.241030928153271 no 796 0.268084195401067 1193 2242070 SGTC_614 0462-0418 107 µM 0.617120330952463 0.241472029195612 no 797 0.268577679748062 1225 5188303 SGTC_2694 st077685 81.9 µM 0.616751126788346 0.24158087497728 no 798 0.268699446384614 1282 2838096 SGTC_1408 3909-7976 48.8 µM 0.616749779411511 0.241581272248789 no 799 0.26869989081161 1335 24152374 SGTC_3334 9142812 21.919 µM 0.616162247626084 0.241754538681372 no 800 0.268893721065672 1363 45283678 SGTC_3135 9127742 49.47 µM 0.615544169786932 0.241936886088717 no 801 0.269097704395184 1315 3643468 SGTC_2851 9015922 71.43 µM 0.615447650068492 0.241965368395158 no 802 0.269129565665726 1352 2996893 SGTC_1037 k284-1091 78.7 µM 0.614023193047139 0.242385927302527 no 803 0.269600000561668 1287 3334711 SGTC_2560 caryophyllene 100 µM 0.613769557903305 0.242460852453109 no 804 0.26968380817696 1346 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2698 st077697 67.5 µM 0.611875036039911 0.243020900780756 no 805 0.270310219712691 1254 3154499 SGTC_1444 4112-3581 28 µM 0.611283448111477 0.243195926061593 no 806 0.270505973405316 1345 2877249 SGTC_309 k408-0051 1.48 µM 0.610298053095853 0.243487613058414 no 807 0.27083219319732 1308 3640463 SGTC_251 melphalan 456.522 µM 0.609603422178002 0.243693344423091 no 808 0.271062272065219 1397 460612 A DNA alkylator. SGTC_1950 st077106 7.18 µM 0.609145637208907 0.243828979551379 no 809 0.271213954998458 1305 13831864 SGTC_3224 9130643 49.47 µM 0.609119079132853 0.243836849579073 no 810 0.271222756076653 1371 17644395 SGTC_2791 5663188 71.43 µM 0.608862636285386 0.243912849045559 no 811 0.271307745970676 1349 54690634 SGTC_195 4234-0266 16.654 µM 0.607403048158839 0.244345656246097 no 812 0.271791733046618 1323 2303354 SGTC_3141 9094609 49.47 µM 0.607023997667453 0.244458122592923 no 813 0.271917493225448 1289 25236309 YDL196W YDL196W SGTC_2834 9001755 58.44 µM 0.606158473210503 0.244715032934655 no 814 0.272204762672557 1340 2989575 SGTC_3341 9147222 25.867 µM 0.604910195191664 0.24508581042775 no 815 0.27261933431752 1323 1939759 SGTC_2432 5630864 12.22 µM 0.604290142193095 0.245270097763407 no 816 0.272825379552216 1308 5714970 SGTC_475 α-linolenic acid 10 µM 0.604164765859161 0.245307370195861 no 817 0.272867051823236 1405 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1508 1080-0625 72.9 µM 0.602521357539027 0.245796211301026 no 818 0.27341357547124 1290 767111 SGTC_1438 4092-1045 4 µM 0.601840134595923 0.245998998128179 no 819 0.273640278350379 1317 1351342 SGTC_1608 st001473 40.5 µM 0.601277147331811 0.24616665621368 no 820 0.273827703968907 1296 7292267 SGTC_2835 9006588 71.43 µM 0.600731623183145 0.246329172207185 no 821 0.274009376429105 1341 2345538 SGTC_2706 st078239 82.5 µM 0.600013715120296 0.246543130357287 no 822 0.274248547553364 1331 15434492 SGTC_970 1315-0089 19.5 µM 0.599754167801222 0.246620507745051 no 823 0.274335041127737 1266 6811083 YLR033W RSC58 SGTC_2612 dictamnine 15.46 µM 0.597365862210995 0.247333130032304 no 824 0.275131570259921 1330 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2187 6125751 200 µM 0.597057669191175 0.247425168742878 no 825 0.275234439307038 1334 874498 SGTC_1085 doxorubicin 7.67 µM 0.595658459552474 0.247843258561497 no 826 0.275701707207649 1374 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_22 0964-0034 14.468 µM 0.595132142296323 0.248000621959453 no 827 0.275877572418934 1316 138402 SGTC_737 1950-0117 57.9 µM 0.594794425592546 0.248101623821999 no 828 0.275990447101405 1315 5393513 SGTC_794 k038-0031 316 µM 0.594519921012449 0.248183736824508 no 829 0.276082211172071 1350 6624242 SGTC_3241 9133421 49.47 µM 0.594449999772801 0.248204654794739 no 830 0.276105587520102 1350 17018221 SGTC_2078 5212016 200 µM 0.593998402572454 0.248339779401829 no 831 0.276256590699698 1299 1899708 SGTC_2964 9083345 53.42 µM 0.593168883716961 0.248588085933382 no 832 0.276534067275486 1313 17741579 SGTC_1353 1498-1206 8.11 µM 0.592508014958117 0.248786003697179 no 833 0.276755227627297 1370 6756808 SGTC_2961 9083290 32.55 µM 0.59105412407403 0.249221711815644 no 834 0.277242078374595 1378 17741490 SGTC_662 k832-1615 104 µM 0.590740974602738 0.249315610847845 no 835 0.277346994594694 1372 5878478 SGTC_2191 5911152 200 µM 0.588603672588822 0.249956990744148 no 836 0.278063584837977 1348 2875902 SGTC_735 3076-0345 636 µM 0.588461522900047 0.249999679274407 no 837 0.278111276510652 1432 2888990 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.588354552269963 0.250031805841902 no 838 0.27814716812802 1377 66535 A nucleotide analog. SGTC_2363 9053361 176 µM 0.587636488871854 0.250247519039472 no 839 0.278388156805261 1446 6469797 YMR079W SEC14 SGTC_1885 st057546 99.9 µM 0.5872117607814 0.250375157903782 no 840 0.278530747334039 1418 702008 SGTC_1770 st043884 66.3 µM 0.587069612288966 0.250417883933895 no 841 0.278578477643088 1347 670149 SGTC_2933 9026794 32.47 µM 0.586357676465169 0.250631930908268 no 842 0.278817589813699 1400 17586027 SGTC_1664 st014217 9.02 µM 0.585243149055923 0.250967213518318 no 843 0.279192117645282 1396 3982782 SGTC_250 brefeldin a 552.239 µM 0.584418208895178 0.251215532547528 no 844 0.279469489443456 1297 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2802 7925815 54.55 µM 0.58377839025306 0.251408216728343 no 845 0.279684709453681 1350 1262923 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.583317827488154 0.251546965555175 no 846 0.279839681756117 1346 279621 SGTC_1822 st052468 42 µM 0.583020729692261 0.251636490497792 no 847 0.279939672700361 1338 2873678 SGTC_2365 9042475 200 µM 0.582350934344601 0.251838382698882 no 848 0.280165161903806 1363 6464479 SGTC_958 1222-0007 33 µM 0.581762135869314 0.252015931122077 no 849 0.280363455854672 1451 7312461 SGTC_1300 1094-0077 113 µM 0.580896339889114 0.252277126289544 no 850 0.280655159652619 1335 5532636 SGTC_1399 3562-5772 25 µM 0.580622745434167 0.252359694513516 no 851 0.280747369558151 1325 23847490 SGTC_1426 4048-4480 71.7 µM 0.579680735981935 0.252644092999254 no 852 0.281064968287917 1407 14224343 SGTC_962 1254-0300 21.5 µM 0.579244991852633 0.252775703931055 no 853 0.281211938226714 1379 7340576 SGTC_2807 7945238 51.95 µM 0.578952284207371 0.252864132789826 no 854 0.281310684944072 1408 17148797 SGTC_2808 7946468 45.46 µM 0.578240022381985 0.253079379662932 no 855 0.281551040731815 1408 2970879 SGTC_620 0109-0052 432 µM 0.577739503257404 0.253230695136283 no 856 0.281720002283777 1381 493037 SGTC_402 epigallocatechin gallate 10 µM 0.577216072951548 0.253388987925342 no 857 0.281896750294795 1368 65064 An antioxidant. SGTC_2177 5811945 192 µM 0.576507010974342 0.25360350129396 no 858 0.282136266187187 1435 5343475 SGTC_3251 9135047 49.47 µM 0.576061740483426 0.253738258252966 no 859 0.282286725328747 1441 17682963 SGTC_951 1171-0579 82.7 µM 0.575331666333848 0.253959289717951 no 860 0.282533504577814 1328 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2274 7947094 46.08 µM 0.573399113743025 0.254544861369826 no 861 0.283187245124966 1361 2971028 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.572957868772658 0.254678659590236 no 862 0.283336610409457 1349 688803 SGTC_2124 5246320 200 µM 0.57084077299385 0.255321136104951 no 863 0.284053790827006 1394 579342 SGTC_2077 5212015 200 µM 0.568872286832974 0.255919273160716 no 864 0.284721406858751 1276 780900 SGTC_2704 st078022 71.1 µM 0.568383062957328 0.256068040313399 no 865 0.284887444240096 1459 54697681 SGTC_2861 9024595 19.48 µM 0.56587713726911 0.256830769150989 no 866 0.285738652221799 1345 16482810 SGTC_2329 6138490 200 µM 0.565598503064359 0.256915650056271 no 867 0.285833372835623 1414 720019 SGTC_244 nsc-207895 1.295 µM 0.563219367880984 0.257641004824018 no 868 0.286642758009752 1306 42640 SGTC_336 4111-0029 111 µM 0.562023760949359 0.258005924540282 no 869 0.287049915124274 1348 3131175 SGTC_446 go6976 132 µM 0.561187303548361 0.258261384965208 no 870 0.287334928654539 1391 3501 A protein kinase C inhibitor. SGTC_3076 9116187 49.47 µM 0.560521909466988 0.258464694941583 no 871 0.287561749840051 1442 27241210 SGTC_3296 9122258 64.045 µM 0.560307742238355 0.258530150989106 no 872 0.287634773699464 1409 4730474 SGTC_2533 agelasine 13.65 µM 0.560006105696619 0.258622354889143 no 873 0.287737636530469 1493 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3314 9135860 59.4275 µM 0.558667795033528 0.259031653363969 no 874 0.288194231127921 1391 25252478 SGTC_900 1112-0045 141 µM 0.557912824397635 0.259262695383414 no 875 0.288451956938761 1330 56211 YIL048W NEO1 SGTC_867 0518-0118 155 µM 0.557383365362664 0.25942478808875 no 876 0.28863276419052 1431 6848158 SGTC_2065 5221596 34.26 µM 0.556621582335732 0.259658098076196 no 877 0.288893002385397 1427 788581 SGTC_1288 0973-0013 65.5 µM 0.554928916418496 0.260176895414635 no 878 0.289471641128988 1447 4315430 SGTC_1162 k048-0130 20.1 µM 0.554121553624908 0.26042453789234 no 879 0.289747830140444 1379 6797406 SGTC_3173 9105693 49.47 µM 0.552887749066914 0.260803217282863 no 880 0.290170138405937 1442 17096658 SGTC_1597 7-benzyloxygramine 47.5 µM 0.550084440691001 0.261664660712476 no 881 0.291130729044727 1405 260807 SGTC_2005 4024620 188 µM 0.549674106750329 0.261790876791166 no 882 0.291271459890613 1395 236743 SGTC_327 1273-0057 3.96 µM 0.548552300629201 0.262136096462615 no 883 0.291656363927554 1371 3108138 SGTC_2253 7938677 135.83 µM 0.548397854830247 0.262183643195365 no 884 0.291709374545369 1516 2301972 SGTC_2442 5158906 48.48 µM 0.547979772488599 0.262312373618042 no 885 0.291852895977475 1508 1893835 SGTC_2879 9041815 71.43 µM 0.54750571147835 0.262458379411819 no 886 0.292015673834598 1374 4942971 SGTC_211 3455-0679 143.504 µM 0.544564772832109 0.263365086266784 no 887 0.293026444190613 1420 748649 SGTC_146 3448-8650 53.125 µM 0.544506076546982 0.263383198905312 no 888 0.293046634010097 1467 2891488 YIL048W NEO1 SGTC_598 3937-0236 20.2 µM 0.544021343988569 0.263532803134191 no 889 0.293213392613759 1455 1379313 SGTC_1718 roemerine 11.9335 µM 0.543090671727479 0.263820160365393 no 890 0.293533687490381 1364 235224 An aporphine alkaloid with mutagenic activity. SGTC_1806 st050005 60.3 µM 0.54174285185133 0.26423660042248 no 891 0.293997832535746 1385 5194765 SGTC_11 0438-0307 1.3 µM 0.540937699097354 0.264485530568908 no 892 0.294275262582234 1488 4011476 SGTC_1372 2752-0194 270 µM 0.53908629774897 0.265058383125724 no 893 0.29491365489416 1377 823334 SGTC_2194 5927483 104.545 µM 0.537610608101827 0.265515435588212 no 894 0.295422952529471 1443 760979 SGTC_1291 0993-0025 5.79 µM 0.536504373643222 0.265858321927143 no 895 0.295805007004706 1507 4353356 SGTC_2681 menadione 3.18 µM 0.536421423679229 0.265884041982245 no 896 0.295833664150482 1419 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2688 kanamycin b 96.69 µM 0.535345062491218 0.266217900471675 no 897 0.296205635698773 1452 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2582 agaric acid 100 µM 0.534040081179293 0.266622955236055 no 898 0.296656901868514 1312 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1841 st054148 70 µM 0.534032015516502 0.266625459715685 no 899 0.296659691975959 1371 675442 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.532860114957449 0.266989474478242 no 900 0.297065208325787 1413 115019 SGTC_3090 9117696 49.47 µM 0.532494475292152 0.267103100513688 no 901 0.297191783607034 1506 7923821 SGTC_551 k048-0028 34.9 µM 0.531840472463057 0.267306399039963 no 902 0.297418244443191 1492 6836383 SGTC_802 4112-3352 742 µM 0.530690864364217 0.267663946924218 no 903 0.297816508881179 1534 704594 SGTC_89 0302-0250 142.109 µM 0.530646845943302 0.267677642199929 no 904 0.297831763234917 1499 4203518 YLR208W SEC13 SGTC_1851 st056236 18.9 µM 0.530616565996607 0.26768706328398 no 905 0.297842256799068 1474 5393171 SGTC_827 3253-0474 693 µM 0.530512794576359 0.267719351242265 no 906 0.297878220230352 1503 5402065 SGTC_248 streptozotocin 5.23457 mM 0.529118821815966 0.268153269055702 no 907 0.298361512731972 1507 5300 DNA alkylating agent. SGTC_1896 st058441 89 µM 0.529079785073905 0.268165425560687 no 908 0.298375051966572 1383 688759 SGTC_1943 st076331 65.2 µM 0.528628535024568 0.268305970313563 no 909 0.298531580719575 1466 24208415 SGTC_438 sphingosine 6.67 µM 0.528443642989909 0.268363566835305 no 910 0.298595726500844 1302 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_159 3970-0959 50 µM 0.527417933723592 0.268683202883496 no 911 0.298951696194106 1504 6615653 SGTC_1459 k035-0031 35.7 µM 0.527064364679161 0.268793427945199 no 912 0.29907444605473 1341 3877128 YMR208W ERG12 SGTC_3205 9113483 49.47 µM 0.524642439940772 0.269549072491952 no 913 0.299915889024382 1552 17018033 SGTC_125 0133-0007 11.75 µM 0.523875016432387 0.269788731802259 no 914 0.300182736342642 1523 26541 SGTC_131 0141-0277 33.849 µM 0.522325691937471 0.270272896530539 no 915 0.300721791936973 1504 1547771 SGTC_1257 0669-0121 16 µM 0.521590659596563 0.270502746374656 no 916 0.300977684013947 1530 4307855 SGTC_938 3126-1755 342 µM 0.519413103495455 0.271184256406596 no 917 0.301736347785714 1475 1777771 SGTC_873 0591-4978 488 µM 0.51930929091294 0.271216768011215 no 918 0.301772537705536 1601 3305145 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.518237378397252 0.271552578810257 no 919 0.302146329250354 1458 6857784 SGTC_2663 amphotericin b 100 µM 0.517608575336212 0.271749667750716 no 920 0.302365698736368 1438 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2676 harmalol 100 µM 0.516639270176149 0.272053621389688 no 921 0.302703998489938 1507 5459187 A monoamine oxidase inhibitor SGTC_2797 7859098 81.82 µM 0.516265762659567 0.272170790566998 no 922 0.302834402576904 1459 972681 SGTC_410 α-linolenic acid 100 µM 0.516212344012241 0.272187550027937 no 923 0.302853054886409 1486 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1039 k821-0043 94 µM 0.516017073338254 0.272248818227835 no 924 0.302921242364152 1546 15992768 SGTC_529 4076-0302 30.3 µM 0.514471482065441 0.272734005189652 no 925 0.303461196864721 1441 5816522 SGTC_749 1000-0129 128 µM 0.513337181203187 0.273090353973908 no 926 0.303857739813929 1577 708470 SGTC_1467 k284-1082 293 µM 0.512849906937593 0.273243505520123 no 927 0.304028158131362 1537 3334705 SGTC_1139 k015-0024 46.9 µM 0.512164997406599 0.273458846243949 no 928 0.304267769009419 1459 2766652 SGTC_1786 berberine 21.6 µM 0.510660532817245 0.273932156021273 no 929 0.304794390601112 1418 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.509417919853594 0.274323391492341 no 930 0.305229659101634 1509 688801 SGTC_1852 st056254 31.4 µM 0.509224504044076 0.274384313072494 no 931 0.305297434531779 1506 442583 SGTC_799 1310-0557 151 µM 0.50906746557893 0.274433781528538 no 932 0.30535246777503 1478 5354492 SGTC_3237 9133362 49.47 µM 0.508835908199283 0.274506732107625 no 933 0.305433623777466 1512 43845137 SGTC_2189 6047310 154.431 µM 0.508493059820378 0.274614761728417 no 934 0.305553802500084 1424 711535 SGTC_513 4245-1575 41.7 µM 0.507877506763398 0.274808771687616 no 935 0.305769625031757 1525 719745 SGTC_2149 5554786 194.827 µM 0.507612296522442 0.274892381449877 no 936 0.305862632695499 1465 745063 YPR165W RHO1 SGTC_3201 9113999 49.47 µM 0.507156033069758 0.275036251675649 no 937 0.306022670890389 1554 16649224 SGTC_2273 7815444 169.05 µM 0.504914365584039 0.275743638638158 no 938 0.30680949189368 1586 2824616 SGTC_2497 7-hydroxyflavone 100 µM 0.50451552711867 0.275869590876659 no 939 0.306949576890641 1509 5281894 SGTC_952 1185-0122 232 µM 0.503647342140502 0.276143859317045 no 940 0.307254609045691 1405 678600 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.502704756196964 0.276441783240495 no 941 0.307585932623016 1448 75037 A free radical scavenger. SGTC_592 k241-0073 46.5 µM 0.500363422238942 0.277182491945889 no 942 0.308409601983613 1562 4230158 SGTC_3190 9110366 49.47 µM 0.498206786816475 0.277865627070199 no 943 0.309169149683937 1552 17123768 SGTC_2902 5787006 60.46 µM 0.495407297077407 0.278753616583819 no 944 0.310156322430425 1464 591003 SGTC_1669 st015249 58.4 µM 0.495102574454517 0.278850356959389 no 945 0.310263858322096 1547 722793 SGTC_2826 7992541 19.48 µM 0.494796838405641 0.278947435483546 no 946 0.310371768155469 1534 2985066 SGTC_861 0443-0273 110 µM 0.493248370853537 0.279439363392122 no 947 0.310918551841535 1514 6149169 SGTC_2218 6965428 192.983 µM 0.491953395208674 0.279851083495455 no 948 0.311376145126638 1542 675684 SGTC_232 clozapine 119 µM 0.490375496949904 0.280353152380179 no 949 0.311934106176074 1501 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.488889151919739 0.28082648868639 no 950 0.312460088115136 1517 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1615 st002656 86.5 µM 0.488549212932666 0.280934798748423 no 951 0.312580438142935 1476 1584458 SGTC_828 2074-0507 139 µM 0.486806014285776 0.281490527048957 no 952 0.31319790392314 1578 X828 SGTC_94 0334-0113 514.748 µM 0.485572387791798 0.281884124945255 no 953 0.313635188823384 1433 6795178 SGTC_568 1193-0097 7.48 µM 0.480943190421174 0.283363465379577 no 954 0.315278437587482 1451 3646150 SGTC_1166 k206-0078 225 µM 0.480658828508405 0.28345445938627 no 955 0.315379498600776 1472 5404595 SGTC_1547 harmine 94.2 µM 0.480179840155027 0.283607764276364 no 956 0.315549760251157 1513 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2997 9067075 71.4286 µM 0.478683616382552 0.284086900946601 no 957 0.316081861469774 1561 27209819 SGTC_1480 1070-0044 41.2 µM 0.477425152215662 0.284490199256509 no 958 0.316529703589963 1553 3124987 SGTC_2968 9090663 33.37 µM 0.476032255391263 0.284936897633739 no 959 0.317025699251435 1528 25236811 SGTC_1701 st028638 40.4 µM 0.473783837515465 0.285658664424496 no 960 0.317827030623051 1607 3490878 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.473647200986457 0.285702554272367 no 961 0.317875755152929 1649 551469 SGTC_519 k048-0011 62.8 µM 0.473567581843546 0.28572813069923 no 962 0.317904148760626 1552 6836379 SGTC_1957 st077035 62.4 µM 0.469737990052169 0.286959612452646 no 963 0.319271111133508 1558 705593 SGTC_60 0986-0278 202 µM 0.46958112132163 0.287010110287569 no 964 0.31932715758071 1348 3110598 SGTC_964 1287-0107 19.4 µM 0.467382561809873 0.287718294176649 no 965 0.320113098284542 1638 51516812 YPR165W RHO1 SGTC_1238 0333-0287 48.8 µM 0.466929507620879 0.287864331211819 no 966 0.320275156531633 1503 7226 SGTC_1663 st014140 55.4 µM 0.466435913920262 0.288023475546731 no 967 0.32045175485479 1596 4207120 SGTC_1550 gossypolone 36.6 µM 0.465269091022523 0.288399847270133 no 968 0.320869383240433 1526 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_52 0329-0193 875 nM 0.464732675784813 0.288572951738771 no 969 0.321061452705724 1606 3739292 SGTC_1673 st016611 27.3 µM 0.464278078402308 0.288719691396567 no 970 0.321224263863995 1613 5226799 SGTC_1473 k844-0725 134 µM 0.463149167583611 0.289084244827998 no 971 0.32162872466829 1573 54682906 SGTC_981 1488-1094 54.9 µM 0.462538086469501 0.28928166841086 no 972 0.321847748172607 1501 3449522 SGTC_3198 9112019 49.47 µM 0.462311073884906 0.289355026102915 no 973 0.321929129729507 1567 45595555 SGTC_853 0419-0306 21 µM 0.462032239767202 0.289445141557736 no 974 0.322029100434086 1478 762713 SGTC_462 ag-879 158 µM 0.461997174588236 0.289456475087345 no 975 0.322041673303329 1611 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2132 5317594 122.667 µM 0.460847836161005 0.289828071801629 no 976 0.322453889447844 1578 794577 SGTC_1048 3161-0300 24.5 µM 0.459886646409055 0.290139009223545 no 977 0.322798792814144 1496 2165101 SGTC_1583 clindamycin 39.6 µM 0.457999197029282 0.29075003887464 no 978 0.323476509077027 1466 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1929 genistein trimethyl ether 50.5 µM 0.457052224429601 0.291056831674145 no 979 0.323816754336251 1709 136420 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.455810675652702 0.291459287901176 no 980 0.324263063308256 1521 229346 A bile salt which induces apoptosis. SGTC_2887 9044784 58.44 µM 0.454772880944204 0.291795894950451 no 981 0.324636321132129 1517 6465546 SGTC_1133 3473-0247 50 µM 0.453708597743661 0.292141281500284 no 982 0.325019288929283 1463 711311 SGTC_2079 5212404 121 µM 0.452161017429209 0.292643849236873 no 983 0.325576494544942 1649 758462 SGTC_3065 9113888 49.47 µM 0.451762473036911 0.292773339221156 no 984 0.325720053479184 1611 16648368 SGTC_2659 sanguinarine 24.21 µM 0.450318535256261 0.293242707812864 no 985 0.326240387971764 1539 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1394 3474-0001 65.7 µM 0.450074362829292 0.293322113338204 no 986 0.326328410931547 1504 5017666 YIL048W NEO1 SGTC_1351 1496-0003 46.5 µM 0.449935575014707 0.293367251947373 no 987 0.32637844756885 1605 3891978 SGTC_3328 9140624 29.0385 µM 0.449460185780882 0.293521889396925 no 988 0.326549861498994 1660 4904392 SGTC_1181 1222-0449 220 µM 0.449268616026609 0.293584215019974 no 989 0.326618947303634 1619 658318 SGTC_560 2332-1943 155 µM 0.448473698889793 0.293842900127568 no 990 0.326905681793908 1572 21177716 SGTC_2988 9073640 71.4286 µM 0.448082374163522 0.293970285299486 no 991 0.327046874064112 1590 9102229 SGTC_2433 5607874 27.82 µM 0.446499471129794 0.294485816882914 no 992 0.327618247272936 1506 2252428 SGTC_879 0831-1030 162 µM 0.446269559548524 0.294560730880993 no 993 0.327701271022236 1541 1549252 SGTC_3148 9097893 49.47 µM 0.445479400010564 0.29481826213652 no 994 0.327986671760541 1420 17174100 SGTC_1703 st026983 48.3 µM 0.445319074442465 0.294870528608814 no 995 0.328044592630856 1642 1104023 SGTC_2203 7227154 166.4 µM 0.445310613341268 0.294873287064232 no 996 0.32804764949054 1554 896304 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.445117393382061 0.294936283123187 no 997 0.328117459886373 1520 23665772 A membrane-active detergent. SGTC_444 curcumin 90.4 µM 0.444680968975076 0.295078594645891 no 998 0.328275162174012 1574 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_452 diindolylmethane 8 µM 0.444421796333091 0.295163121962973 no 999 0.328368828890227 1593 3071 Inhibits expression of several cancer promoting factors. SGTC_2129 girgensonine 121.053 µM 0.443704675263117 0.295397063989671 no 1000 0.328628057426886 1638 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2967 9089538 49.85 µM 0.443511527528471 0.295460087973885 no 1001 0.328697891549453 1736 728216 SGTC_945 3381-0768 11.3 µM 0.442087497324773 0.295924938900974 no 1002 0.329212945676898 1583 1126236 YIL048W NEO1 SGTC_48 0382-0018 55 µM 0.439701574842219 0.296704535288594 no 1003 0.33007663091391 1702 762596 SGTC_675 1309-0189 238 µM 0.43930643111163 0.296833738595539 no 1004 0.330219757456311 1527 4246530 SGTC_1546 5-methoxyflavanone 78.7 µM 0.439158406198183 0.29688214611507 no 1005 0.33027338053248 1643 147795 SGTC_1695 st026914 34.495 µM 0.439036484882473 0.296922019876252 no 1006 0.330317550013079 1532 3289191 SGTC_2646 retinol 96.75 µM 0.437636491432201 0.297380056289315 no 1007 0.330824906963257 1587 445354 A vitamin A analog and teratogen. SGTC_1248 0469-0687 58.6 µM 0.437602782898659 0.297391088701779 no 1008 0.330837126756322 1643 4017482 SGTC_3216 9129716 49.47 µM 0.436339906096554 0.297804548278789 no 1009 0.331295066224032 1497 8056934 SGTC_2853 9015042 58.44 µM 0.43622562028983 0.29784197781598 no 1010 0.331336520561898 1480 6457456 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.435059882082823 0.298223889103344 no 1011 0.33175948112235 1617 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.434549696158456 0.298391102904387 no 1012 0.331944657557211 1582 97141 SGTC_269 exalamide 29 µM 0.434332550426508 0.298462285516667 no 1013 0.332023484955017 1613 3316 A derivative of salicylamide. SGTC_758 0868-0029 16 µM 0.432940064703487 0.298918940233442 no 1014 0.33252915627681 1707 762687 SGTC_3179 9107801 49.47 µM 0.431476599120541 0.299399214005743 no 1015 0.333060932071547 1547 4818259 SGTC_2575 plumbagin 510 nM 0.430817972474886 0.299615473350411 no 1016 0.333300365229565 1511 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_992 3909-8734 162 µM 0.430605955515418 0.299685103945206 no 1017 0.33337745505733 1561 4288319 SGTC_1507 4075-3230 155 µM 0.429289051796742 0.300117765441003 no 1018 0.33385644163357 1570 659771 SGTC_78 0336-0123 156.75 µM 0.427564001673049 0.300684948201002 no 1019 0.33448428963888 1532 6765896 SGTC_1355 1499-0035 1.68 µM 0.427179292837978 0.300811503352185 no 1020 0.334624371219967 1556 1548538 SGTC_471 1-acyl-paf 4 µM 0.425579387840124 0.30133807120851 no 1021 0.335207181223465 1526 16759367 SGTC_1777 st045864 34.765 µM 0.42469698128424 0.301628670240501 no 1022 0.335528792338939 1595 4691462 SGTC_511 blebbistatin 171 µM 0.424375323044163 0.301734631858479 no 1023 0.335646057254013 1679 3476986 A myosin inhibitor. SGTC_451 chloral hydrate 100 µM 0.422903927862442 0.302219556478934 no 1024 0.336182678461684 1625 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_622 1348-1566 26.3 µM 0.422884819583495 0.302225856254275 no 1025 0.336189649494089 1672 7340407 SGTC_177 1327-0068 8.361 µM 0.42224933540307 0.302435401492298 no 1026 0.336421517247951 1559 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_808 0711-0032 135 µM 0.420921700645394 0.302873387293893 no 1027 0.336906129209896 1734 4252555 SGTC_1573 oleylamine 1.06 µM 0.420120189986901 0.303137942502721 no 1028 0.337198827040553 1563 5356789 An amine of the fatty acid oleic acid. SGTC_1933 st074711 15.9 µM 0.41811200766872 0.30380123812039 no 1029 0.337932613052115 1549 17250958 SGTC_1376 2910-0861 41.3 µM 0.416808336669478 0.304232182416364 no 1030 0.33840930206807 1624 1112859 SGTC_687 k029-0044 34.9 µM 0.414714582620836 0.304924867434995 no 1031 0.339175427916548 1729 5829338 SGTC_88 0180-0332 8.668 µM 0.413603388700028 0.305292772530144 no 1032 0.339582295551811 1643 3101745 SGTC_1090 efavirenz 20.7 µM 0.413492979210824 0.305329338751528 no 1033 0.339622732604047 1657 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2452 5863136 48.41 µM 0.412623388083642 0.305617404174822 no 1034 0.339941281518744 1573 2184096 SGTC_772 k072-0172 35.3 µM 0.41217527349052 0.30576589602226 no 1035 0.34010547965455 1504 5861980 SGTC_2624 nerol 100 µM 0.411383534120702 0.306028332963008 no 1036 0.340395662888758 1695 637566 A natural product oil. SGTC_3039 9090270 49.47 µM 0.410761639249924 0.306234541593757 no 1037 0.340623662101954 1711 17173750 SGTC_216 k038-0035 28.382 µM 0.41048788466679 0.306325332925764 no 1038 0.340724044526706 1658 4444231 YPR107C YTH1 SGTC_316 k060-0003 58.6 µM 0.410191205575621 0.306423740651877 no 1039 0.340832845822708 1674 6152314 SGTC_610 4215-0184 155 µM 0.409620008415449 0.306613244662327 no 1040 0.341042358571616 1631 5605015 SGTC_954 1189-0853 2.85 µM 0.409141984521208 0.306771876668182 no 1041 0.341217733438244 1587 2828194 SGTC_1587 estradiol valerate 56.1 µM 0.407716274766056 0.307245212656013 no 1042 0.341740993851247 1732 13791 A steroid. SGTC_203 k066-0004 30.888 µM 0.406325751846757 0.307707176149822 no 1043 0.342251633168168 1682 6795412 SGTC_3242 9133940 49.47 µM 0.403039557570135 0.308800136341326 no 1044 0.343459562026182 1656 17248444 SGTC_2496 diffractaic acid 79.83 µM 0.402871409322511 0.308856106691914 no 1045 0.343521412571874 1729 94870 An apoptosis inducer which activates caspases. SGTC_960 1222-0186 7.7 µM 0.40235619044697 0.309027631691048 no 1046 0.343710953377228 1689 3126296 SGTC_3258 9138477 49.47 µM 0.402098083294944 0.309113575548225 no 1047 0.343805921657719 1666 4970355 SGTC_650 1328-0195 38 µM 0.401068575156477 0.309456482441464 no 1048 0.344184818231824 1700 2780821 SGTC_1570 verbenone 133 µM 0.400111647470326 0.309775363206983 no 1049 0.344537142878295 1747 29025 A natural terpanoid with antifungal properties. SGTC_297 0986-0032 24 µM 0.399004367139665 0.310144525291699 no 1050 0.344944993204057 1608 2847425 SGTC_1865 st057639 52.2 µM 0.398077922902173 0.310453544579899 no 1051 0.345286373731818 1621 688818 SGTC_2723 salbutamol 83.58 µM 0.39769527345444 0.310581217944322 no 1052 0.345427410959147 1691 9884233 β2-adrenoceptor agonist SGTC_348 k064-0012 10.7 µM 0.39752945719074 0.310636550657997 no 1053 0.345488534311953 1597 5066323 SGTC_3174 9107204 49.47 µM 0.396625811928211 0.310938171399506 no 1054 0.345821707683201 1679 3938802 SGTC_2779 methotrexate 400 µM 0.39610868359348 0.31111083682976 no 1055 0.346012426281287 1632 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2918 7977171 22.06 µM 0.396078068883707 0.311121060165114 no 1056 0.346023718310421 1613 2236483 SGTC_2953 9074162 66.49 µM 0.395560324347562 0.31129397546061 no 1057 0.346214705620472 1787 16451992 SGTC_1017 4239-0030 168 µM 0.395363193697713 0.311359823714155 no 1058 0.346287434108864 1550 1149593 SGTC_145 3737-0113 38.366 µM 0.394356858325627 0.311696067523741 no 1059 0.346658795199008 1762 6849351 SGTC_612 0302-0167 22.4 µM 0.394122166493585 0.311774506994382 no 1060 0.346745423136627 1724 235821 SGTC_3313 9133968 57.047 µM 0.390245073942481 0.313071555162332 no 1061 0.348177667173826 1641 1494643 SGTC_2893 9048488 25.97 µM 0.390068377206316 0.313130722857698 no 1062 0.348242992854982 1573 6467338 SGTC_1203 3992-3522 103 µM 0.388420722541543 0.313682678887377 no 1063 0.348852355673514 1862 5322312 SGTC_1013 4112-3890 241 µM 0.388209201159193 0.313753567739107 no 1064 0.348930612283802 1609 705171 SGTC_2378 9074213 121.43 µM 0.388026727498313 0.313814727120717 no 1065 0.348998127265691 1622 657714 SGTC_3095 9117207 49.47 µM 0.386629687096764 0.314283140166257 no 1066 0.349515188395322 1781 17015229 SGTC_20 0481-0013 4.944 µM 0.386267977728066 0.314404466334667 no 1067 0.349649106861391 1605 182045 SGTC_290 2043-6722 48.1 µM 0.386215082702246 0.314422210300654 no 1068 0.349668692165829 1658 773758 YLR208W SEC13 SGTC_246 cycloheximide 667 µM 0.385824442623716 0.314553266222041 no 1069 0.349813345843191 1622 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_516 3992-2719 87.3 µM 0.384372015279573 0.315040746250139 no 1070 0.350351369502278 1551 5350887 YDR037W KRS1 SGTC_2965 9082772 38.63 µM 0.383886250988259 0.3152038559072 no 1071 0.350531378596291 1811 16459634 SGTC_2283 7944793 200 µM 0.383753420350282 0.315248463977972 no 1072 0.35058060733392 1573 2970533 SGTC_2514 salinomycin 42.74 µM 0.38369099329458 0.315269429578706 no 1073 0.350603744468099 1802 23682228 A polyether potassium ionophore. SGTC_1311 1190-0148 100 µM 0.382838422636212 0.315555817772467 no 1074 0.35091978536071 1749 1961333 SGTC_279 1273-0055 2.93 µM 0.380370209449182 0.316385542999975 no 1075 0.3518353125703 1761 2847562 SGTC_1636 st007707 68.9 µM 0.379124282086009 0.316804730993719 no 1076 0.35229778772121 1773 403051 SGTC_492 tmb-8 126 µM 0.378768848321624 0.316924358630019 no 1077 0.352429761086979 1735 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3131 9127911 49.47 µM 0.378750769696814 0.316930443828534 no 1078 0.35243647419651 1696 45595681 SGTC_394 menadione 8.33 µM 0.377203546338842 0.317451416842363 no 1079 0.353011172513394 1702 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2890 9046729 58.44 µM 0.376866314636472 0.317565015808901 no 1080 0.353136477922668 1599 903329 SGTC_1804 st050076 49.1 µM 0.376752728723678 0.317603281923243 no 1081 0.353178686702404 1699 3895976 SGTC_21 0849-0113 22.993 µM 0.374151589367867 0.318480115963074 no 1082 0.354145769296529 1630 1560156 SGTC_210 3551-0445 56.827 µM 0.372545226500799 0.319022123349952 no 1083 0.354743472712509 1718 2865180 YOR207C RET1 SGTC_2170 morpholine 200 µM 0.372205901193084 0.319136665621694 no 1084 0.354869776363902 1740 121171 Reacts with secondary amines. SGTC_1623 st003709 20.3 µM 0.371531077341423 0.319364509721011 no 1085 0.355121006666858 1622 16192618 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.367738071271556 0.320646428481058 no 1086 0.356534274949339 1685 368090 SGTC_1129 3453-1384 223 µM 0.367720430938226 0.320652395383916 no 1087 0.356540852332777 1722 1084452 SGTC_2128 5255449 168.493 µM 0.367690159424735 0.320662634934503 no 1088 0.356552139483744 1638 736008 SGTC_466 geldanamycin 89.2 µM 0.367669279798941 0.320669697693092 no 1089 0.356559924813169 1753 5288382 HSP90 inhibitor. SGTC_3140 9094243 49.47 µM 0.364186484092829 0.321848697811692 no 1090 0.357859379567519 1738 19291112 SGTC_2541 muurolladie-3-one 83.07 µM 0.364127024508904 0.321868841764288 no 1091 0.357881578700113 1704 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2197 6588183 93.1375 µM 0.36292639195048 0.322275708746693 no 1092 0.358329935529605 1700 884136 SGTC_3219 9131112 49.47 µM 0.362147358599127 0.32253981936486 no 1093 0.358620957513355 1688 17612988 YMR079W SEC14 SGTC_733 4069-0007 56.1 µM 0.361902021810264 0.322623012856157 no 1094 0.358712624512998 1728 5717425 YNL287W SEC21 SGTC_1122 capsaicin 818.572 nM 0.361632366713706 0.322714462909111 no 1095 0.35881338713113 1755 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1788 fluconazole 20 µM 0.361218333409186 0.32285489784388 no 1096 0.358968118999125 1645 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3106 9121286 49.47 µM 0.361217214726386 0.322855277321369 no 1097 0.358968537102842 1762 15943471 SGTC_788 1182-0090 188 µM 0.359771400868928 0.323345877638149 no 1098 0.359509045937986 1843 5715185 SGTC_237 nikkomycin 200 µM 0.357043467175888 0.324272369323154 no 1099 0.360529632666337 1776 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1650 st011916 45.8 µM 0.356488206595999 0.324461086787003 no 1100 0.360737491266428 1800 242528 SGTC_547 1120-0019 610 nM 0.355922820445732 0.324653291978597 no 1101 0.360949182595923 1691 3676939 SGTC_2697 mebhydrolin 72.4 µM 0.355411849001875 0.324827038863015 no 1102 0.361140536676448 1833 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2729 fluphenazine 10.66 µM 0.354486787317484 0.325141686821598 no 1103 0.361487052106052 1627 3372 An atypical antipsychotic. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.35407529674762 0.325281690197201 no 1104 0.361641227370422 1816 756377 SGTC_2986 9022445 71.43 µM 0.353737291538814 0.325396709753955 no 1105 0.361767886307123 1824 6459286 SGTC_2305 7443522 69.23 µM 0.353610440329559 0.325439880156364 no 1106 0.361815424511167 1772 5415886 SGTC_1364 1653-0028 37.6 µM 0.351831078025792 0.326045684952885 no 1107 0.362482474979083 1697 5718652 SGTC_1396 3511-0007 98.6 µM 0.350985819509735 0.326333624203371 no 1108 0.362799493439996 1693 X1396 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.348554127781146 0.327162562444317 no 1109 0.363712035531474 1686 5106787 A p450 inhibitor. SGTC_1187 1391-0724 117 µM 0.34632368004416 0.327923649204525 no 1110 0.364549737182258 1736 6997986 SGTC_1691 st019933 84.6 µM 0.345112376890403 0.328337277223535 no 1111 0.365004944510211 1821 6176082 SGTC_2628 lathosterol 100 µM 0.344674912767531 0.328486711431318 no 1112 0.365169390197004 1714 6710616 SGTC_2684 capsaicin 100 µM 0.344423077525996 0.328572748759854 no 1113 0.365264067995251 1739 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_750 4073-0104 132 µM 0.343341977794895 0.328942200331334 no 1114 0.365670602130499 1681 22330957 SGTC_1268 0828-0275 2.46 µM 0.342310714341403 0.329294776830083 no 1115 0.366058536610461 1770 745337 SGTC_2009 4012297 12.05 µM 0.342043241226778 0.329386247465647 no 1116 0.366159175421341 1682 45595307 SGTC_636 0kpi-0074 126 µM 0.34127463620942 0.32964915234179 no 1117 0.36644842017723 1712 616434 SGTC_1729 st035615 45.989 µM 0.340422712459315 0.329940655164609 no 1118 0.366769108456377 1701 17385451 SGTC_1463 k081-0032 34.1 µM 0.339581672670945 0.330228535153612 no 1119 0.367085790946945 1634 977755 SGTC_1652 st011932 78 µM 0.338993918645835 0.330429777500765 no 1120 0.367307155717342 1797 1551076 SGTC_223 busulfan 5 mM 0.337380830641287 0.330982338003051 no 1121 0.367914916683426 1778 2478 A DNA alkylator. SGTC_333 3486-0131 40.1 µM 0.335350904849001 0.331678208948181 no 1122 0.368680199019025 1849 6744690 SGTC_2952 9073731 13.78 µM 0.333426571294379 0.332338419024627 no 1123 0.369406154285912 1671 16457353 SGTC_3213 9129884 49.47 µM 0.33175761422165 0.33291143490873 no 1124 0.370036146094127 1615 17190742 SGTC_2736 butenafine 14.65 µM 0.331721843367047 0.332923720670081 no 1125 0.370049652570308 1802 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_319 1348-1596 45.5 µM 0.331703483594301 0.332930026537821 no 1126 0.370056584975543 1855 5380505 SGTC_2001 4023502 57.655 µM 0.330492324267092 0.33334611694684 no 1127 0.370513995734329 1762 108941 YCR052W RSC6 SGTC_1737 st035557 69.7 µM 0.330354724996555 0.333393401779865 no 1128 0.370565973562037 1669 5716916 SGTC_3145 9085516 49.47 µM 0.329865949802306 0.333561386669282 no 1129 0.370750626434753 1676 25236195 SGTC_2709 st078560 56 µM 0.328946454840701 0.333877494080347 no 1130 0.371098080259191 1853 17250903 SGTC_245 methotrexate 289.6 µM 0.328419030332739 0.334058867282004 no 1131 0.371297428056831 1789 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3109 9122853 49.47 µM 0.326921755641471 0.334573968191763 no 1132 0.371863532903369 1781 1234709 SGTC_3063 1327-0034 4 µM 0.326568763043336 0.334695452118022 no 1133 0.371997036353097 1798 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_840 0245-0196 390 µM 0.325987649294286 0.334895482613072 no 1134 0.372216849804726 1802 3827528 SGTC_18 0111-0177 500 nM 0.322690895168166 0.336031173992905 no 1135 0.373464674093892 1761 721752 SGTC_2477 5967686 25.23 µM 0.322033098245066 0.336257956628035 no 1136 0.373713810130332 1703 776118 SGTC_2944 9067346 25.62 µM 0.321853994472872 0.336319714925453 no 1137 0.37378165359171 1777 6473075 SGTC_1126 isoteolin 1.0172 µM 0.320106306588022 0.33692258169315 no 1138 0.37444387252011 1655 133323 SGTC_3171 9103192 49.47 µM 0.319856900772959 0.337008648704336 no 1139 0.37453840549368 1842 13018434 SGTC_2505 galangin 7.89 µM 0.318926400514885 0.337329828670827 no 1140 0.374891162084469 1699 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1395 3486-0190 4.35 µM 0.317227665432778 0.337916485285734 no 1141 0.375535429604104 1890 6748079 SGTC_1098 clofazimine 15.1 µM 0.317188724508915 0.337929938122154 no 1142 0.375550202537358 1822 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1100 amiodarone 5.07 µM 0.314434398996506 0.338881993226041 no 1143 0.376595566694562 1913 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_273 hydroxyurea 18.1 mM 0.313479631129936 0.339212257281028 no 1144 0.376958146704925 1788 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1754 st042065 16.137 µM 0.31334794670998 0.339257817983109 no 1145 0.377008163340762 1796 1126236 YIL048W NEO1 SGTC_1296 1068-0102 11.9 µM 0.312777275748234 0.339455288158144 no 1146 0.377224940551976 1835 767053 SGTC_1687 st020778 55.3625 µM 0.312155969331847 0.339670329930515 no 1147 0.377460996333988 1796 4259299 SGTC_2506 ethyl hematommate 54.16 µM 0.31102694453416 0.340061232836016 no 1148 0.377890069017076 1688 3940691 An allergen. SGTC_1147 3809-1045 12.3 µM 0.310371297426215 0.340288316881592 no 1149 0.37813930923891 1750 325925 SGTC_2195 6536160 144.242 µM 0.309628126875481 0.340545784807514 no 1150 0.378421882287711 1729 3834386 SGTC_2962 9082311 13.18 µM 0.308756756795979 0.340847761513303 no 1151 0.378753282992638 1698 16459453 SGTC_990 3985-0011 41.3 µM 0.308716646735761 0.340861664268659 no 1152 0.378768539856214 1756 5399565 YGL099W LSG1 SGTC_55 0767-0285 6.563 µM 0.308641410332685 0.340887742930252 no 1153 0.378797158411467 1892 3116166 SGTC_80 0159-0065 512.242 µM 0.30724967148283 0.341370288517847 no 1154 0.379326670174996 1874 1548079 SGTC_1050 3232-1156 69.3 µM 0.304052807880369 0.342479690855372 no 1155 0.380543829772521 1735 700529 SGTC_2431 5490079 200 µM 0.301884178753278 0.343233041770471 no 1156 0.381370178475569 1731 5722345 SGTC_3069 9117009 49.47 µM 0.301278109844568 0.343443693077243 no 1157 0.381601215863498 1872 41904981 SGTC_2898 9056270 58.44 µM 0.298721061394103 0.344332980971462 no 1158 0.382576442865506 1799 19154699 SGTC_1920 st075728 45.7 µM 0.297344407703916 0.344812109312405 no 1159 0.383101790713416 1920 3400306 SGTC_2673 kobusone 100 µM 0.297179280480599 0.344869596665349 no 1160 0.383164819741972 1831 6710676 An epoxy ketone and protein crosslinker. SGTC_562 3772-2733 112 µM 0.297155740176434 0.34487779227305 no 1161 0.383173805323364 1883 2876874 YIL048W NEO1 SGTC_1233 0325-0408 14.2 µM 0.296673902355527 0.345045561137296 no 1162 0.383357741685295 1852 12874 SGTC_688 0527-0193 473 µM 0.295615656135072 0.345414133842497 no 1163 0.38376180794229 1822 4007154 SGTC_3113 9123498 49.47 µM 0.295532672032427 0.345443042276415 no 1164 0.383793498807586 1880 8897275 SGTC_2088 5278280 127.392 µM 0.295009872903157 0.345625185885383 no 1165 0.383993168848851 1802 791502 SGTC_2193 5925765 200 µM 0.294998587817062 0.345629118012106 no 1166 0.38399747924476 1872 877370 SGTC_2288 7946289 167.31 µM 0.293269884465836 0.346231656413008 no 1167 0.384657935424128 1905 1246052 SGTC_3087 9117406 49.47 µM 0.293269785368435 0.346231690964518 no 1168 0.384657973294197 1790 42546093 SGTC_1384 3089-0840 101 µM 0.292573136192219 0.346474617756394 no 1169 0.384924224942358 1895 1069836 SGTC_501 nsc-95397 161 µM 0.292557416744442 0.346480099974719 no 1170 0.384930233368878 1884 262093 SGTC_2266 7929956 200 µM 0.292294937197339 0.346571645484543 no 1171 0.385030564707284 1756 2967153 SGTC_3217 9129673 49.47 µM 0.29188396143656 0.346715000310087 no 1172 0.38518767335249 1802 17248312 SGTC_2836 9010338 19.48 µM 0.291379457419567 0.346891009276435 no 1173 0.38538056193552 1646 2994051 SGTC_116 0155-0182 31.788 µM 0.291055267667913 0.347004128499537 no 1174 0.385504525375627 1769 771486 SGTC_2765 myclobutanil 7.74 µM 0.290923427073008 0.347050135414294 no 1175 0.38555494183237 1788 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1111 tnp00062 510.699 nM 0.290381161590094 0.34723938734051 no 1176 0.385762327000498 1913 676306 SGTC_1062 mesoridazine 14.2 µM 0.289930366066828 0.347396745039074 no 1177 0.385934755064095 1788 4078 A neuroleptic. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.289099568938518 0.34768681753387 no 1178 0.386252591728762 1870 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2932 9016711 44.54 µM 0.288346729890241 0.347949748033327 no 1179 0.386540670044925 1947 7117328 SGTC_1068 loratadine 26.9 µM 0.287828643390382 0.348130733235589 no 1180 0.386738955248307 1771 3957 A H1 histamine antagonist. SGTC_3268 9137683 49.47 µM 0.287539059653804 0.348231909740945 no 1181 0.38684979937663 1792 1953228 SGTC_1337 1486-1011 40.3 µM 0.287091354864537 0.348388352787293 no 1182 0.387021185751127 1877 X1337 SGTC_1171 0368-0077 21.4 µM 0.286953058611808 0.348436683345334 no 1183 0.387074131550426 1790 3239779 SGTC_908 3448-7491 47.7 µM 0.285477017129379 0.348952670486807 no 1184 0.387639354903889 1747 1203031 SGTC_673 1082-0474 110 µM 0.283257451252271 0.34972910093945 no 1185 0.388489745544479 1758 3098046 SGTC_178 4092-0806 87.505 µM 0.282196596754514 0.350100422760541 no 1186 0.38889638386009 1818 2169044 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.280310271639784 0.350761030914291 no 1187 0.389619735462753 1854 2724278 An inhibitor of dopamine biosynthesis. SGTC_2161 5662504 8.5105 µM 0.280234041714531 0.35078773682914 no 1188 0.389648975512351 1779 2859334 SGTC_1256 0570-0116 285 µM 0.27944139691155 0.35106547071532 no 1189 0.389953052851409 1743 410638 SGTC_2805 7950783 58.44 µM 0.279416961527662 0.35107403386605 no 1190 0.389962427915187 1836 1178958 YDL195W SEC31 SGTC_555 4296-0685 37 µM 0.279125841355903 0.35117606001184 no 1191 0.390074126199816 1850 2908540 YHR072W ERG7 SGTC_2109 5483026 200 µM 0.278638705378066 0.351346805962243 no 1192 0.39026105299972 1820 759335 SGTC_2345 9052315 157.45 µM 0.274536597900683 0.352785822152651 no 1193 0.391836141269951 1802 6469265 SGTC_2306 7482397 179.52 µM 0.274378036563933 0.352841487809347 no 1194 0.391897059931517 1919 891448 SGTC_739 1486-1183 203 µM 0.272871425173443 0.353370566415801 no 1195 0.392476026322013 1961 4346692 SGTC_893 0958-0369 48.9 µM 0.272854429864767 0.353376536298417 no 1196 0.392482558704465 1959 6819948 SGTC_1661 st013063 9.66 µM 0.272613378182764 0.353461213563138 no 1197 0.392575213520469 1810 721395 SGTC_1805 st050013 60.3 µM 0.27148982045104 0.353855995493743 no 1198 0.393007163959696 1913 4037144 SGTC_698 k064-0052 127 µM 0.271080310758778 0.353999923094529 no 1199 0.393164632270763 1877 5088751 SGTC_1783 st039459 87.517 µM 0.270618817730598 0.354162145931021 no 1200 0.39334211062656 1953 729761 SGTC_2255 7941087 197.44 µM 0.27049812145905 0.354204577140392 no 1201 0.393388530968214 1952 935561 SGTC_2188 6126565 140.678 µM 0.269670450554204 0.354495596573465 no 1202 0.393706897806369 1915 874518 SGTC_762 1165-0429 115 µM 0.269341091199277 0.354611427080666 no 1203 0.39383360694353 1946 5967793 SGTC_3040 9091894 49.47 µM 0.269041121792335 0.35471693330472 no 1204 0.393949019139177 1916 25236966 SGTC_829 1635-0120 117 µM 0.266933050266606 0.355458705114561 no 1205 0.394760354590585 1942 285054 SGTC_2880 9042983 58.44 µM 0.265801644449076 0.355857041500895 no 1206 0.395195988337431 1828 6464714 SGTC_2347 9049783 174.81 µM 0.262817327105551 0.356908490552311 no 1207 0.396345689896161 1911 6467988 YPL169C MEX67 SGTC_3291 9121177 71.43 µM 0.262564944662966 0.356997461152276 no 1208 0.396442961170152 1810 17015612 SGTC_2695 st077686 51.995 µM 0.261116253086877 0.357508308483397 no 1209 0.397001429104208 1799 2876092 SGTC_1158 4092-0494 91.8 µM 0.26103220940401 0.357537952377246 no 1210 0.397033834284229 1917 1148199 SGTC_2242 6630449 61.2675 µM 0.259837166695459 0.357959560854015 no 1211 0.397494690224908 1882 691249 YDR170C SEC7 SGTC_2870 9038528 12.99 µM 0.25940049885471 0.358113659582284 no 1212 0.397663122426854 1844 6463316 SGTC_1244 0416-0015 52.5 µM 0.259053427689751 0.358236156412112 no 1213 0.397797008869553 1837 96201 SGTC_1088 bifonazole 369 nM 0.258972742808267 0.358264635781562 no 1214 0.397828135657366 1902 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2246 7293507 91.5585 µM 0.258487324049775 0.358435990839577 no 1215 0.398015415274815 1990 887656 SGTC_442 cape 100 µM 0.258228355628673 0.358527419549289 no 1216 0.398115337606943 1968 5281787 SGTC_1475 4092-1048 11.7 µM 0.257965416886257 0.358620258276526 no 1217 0.398216798714598 1853 2881759 SGTC_2641 levomentholum 100 µM 0.257856422189062 0.358658744705061 no 1218 0.398258858904134 1905 16666 SGTC_2358 9037157 4 µM 0.257543605505001 0.358769209396779 no 1219 0.398379578945782 1875 2388925 SGTC_907 3448-6986 75.5 µM 0.257466586822855 0.358796408751842 no 1220 0.398409302953115 1938 590582 SGTC_1622 st003707 19.4 µM 0.255059921354334 0.359646689282394 no 1221 0.399338409348446 1879 10140899 SGTC_3169 9102970 49.47 µM 0.251645243832793 0.360854295103633 no 1222 0.400657642082017 1906 17027839 SGTC_358 0075-0058 9.45 µM 0.2506888215101 0.361192784743166 no 1223 0.401027351953744 2080 1069125 SGTC_2035 5154463 94.595 µM 0.249276333987532 0.361692880238885 no 1224 0.401573518180311 1966 2769623 SGTC_2868 9035608 32.47 µM 0.24686252668258 0.362548042647673 no 1225 0.402507309131649 1826 6462614 SGTC_1193 1488-0126 41.5 µM 0.245794200280872 0.362926748095809 no 1226 0.402920773435213 1838 1384710 SGTC_572 0960-0087 17.7 µM 0.244514257463795 0.36338064488226 no 1227 0.403416280586646 1797 6796365 SGTC_1522 st012842 45.6 µM 0.244263492427758 0.363469594357661 no 1228 0.403513378015204 1762 3491067 YOR116C RPO31 SGTC_678 1218-2179 85.9 µM 0.244033669246968 0.363551121961802 no 1229 0.40360237188014 1907 6820081 YOR116C RPO31 SGTC_632 0781-2353 4.65 µM 0.243984342883451 0.363568620829323 no 1230 0.403621473057293 1917 6811515 YHR007C ERG11 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.243466455061322 0.363752362281145 no 1231 0.403822034185766 1977 6728940 SGTC_427 1354-0053 47.3 µM 0.242887902182341 0.363957664150468 no 1232 0.404046118824748 1958 6813657 SGTC_2584 androsterone 48.74 µM 0.242599845605649 0.364059896779145 no 1233 0.404157700415294 1938 2754130 A steroid. SGTC_3225 9130819 49.47 µM 0.242382991689965 0.364136865633735 no 1234 0.404241706089624 1956 4547121 SGTC_2399 5884133 200 µM 0.242062539162568 0.364250615203213 no 1235 0.40436585226111 1827 722445 SGTC_2199 6590217 200 µM 0.241089155950484 0.364596205886847 no 1236 0.404743008615701 1951 703109 SGTC_718 1130-0073 349 µM 0.240824696936584 0.364690118634837 no 1237 0.404845493736616 1937 6740020 SGTC_1262 0737-0114 49.6 µM 0.240084816572451 0.364952902653428 no 1238 0.405132252324136 2008 765919 SGTC_2267 7931562 200 µM 0.23912575536951 0.365293627748207 no 1239 0.405504035556795 1747 934880 SGTC_1439 4092-1168 46 µM 0.238705970594535 0.365442797911708 no 1240 0.405666793356514 1919 2886240 SGTC_2017 5132927 60.65 µM 0.23600971350397 0.366401394948639 no 1241 0.406712566389962 1850 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.235204235574025 0.366687927640792 no 1242 0.407025109346634 1966 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_144 4161-2749 112.381 µM 0.23451394763794 0.366933542926583 no 1243 0.407293003207575 1932 797501 YMR168C CEP3 SGTC_2960 9079389 5.97 µM 0.232720343579634 0.367571989880135 no 1244 0.407989285499313 1999 16457355 SGTC_1903 st060211 78.3 µM 0.231984898603075 0.367833883049278 no 1245 0.408274871525549 2007 688960 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.231227405034203 0.368103692007807 no 1246 0.408569070342464 1986 94937 An inhibitor of serotonin biosynthesis. SGTC_2173 5763948 167 µM 0.230413824394559 0.368393550901497 no 1247 0.408885109907366 1998 2867177 SGTC_1685 st024049 53.0905 µM 0.22841684321344 0.369105343799764 no 1248 0.409661098268459 1943 1941139 SGTC_1264 0783-0040 158 µM 0.227544305853108 0.369416487298149 no 1249 0.410000260766765 1833 2855798 SGTC_2905 7799065 20.05 µM 0.226362215126364 0.369838152776204 no 1250 0.410459856596543 2012 1296806 SGTC_2400 5203494 178.7 µM 0.225437728743176 0.370168036917416 no 1251 0.4108193818268 1922 6777674 SGTC_1490 4089-0339 670 nM 0.224793045374871 0.370398135601124 no 1252 0.411070138308566 2012 742542 SGTC_3353 9151644 39.2805 µM 0.224745215198252 0.370415208870427 no 1253 0.41108874381601 1906 4909158 SGTC_563 tetrahydrosecaminediol 614 µM 0.224651986742615 0.3704484880622 no 1254 0.411125009419468 2017 334274 A psychoactive constituent of the cannabis plant. SGTC_1154 4088-0362 150 µM 0.224619584175227 0.370460054835625 no 1255 0.411137614103693 1891 6618304 SGTC_3245 9134821 49.47 µM 0.222423320808546 0.371244329419925 no 1256 0.411992179543003 1848 17014901 SGTC_2925 9010536 32.5 µM 0.22229858119502 0.37128888939278 no 1257 0.412040728258777 1949 2994177 SGTC_2625 euphol 100 µM 0.221986280122489 0.371400458369956 no 1258 0.412162281884789 2037 6708538 A triterpene alcohol. SGTC_352 k048-0007 5.11 µM 0.221726412979968 0.371493303660515 no 1259 0.412263433633826 2001 6811911 SGTC_2003 4023581 200 µM 0.220600588765837 0.371895624254373 no 1260 0.4127017212929 1885 16641307 SGTC_92 0063-0024 660.874 µM 0.218283756839303 0.372723999017648 no 1261 0.413604014745699 2043 3594437 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.217850323877525 0.372879036898986 no 1262 0.413772866642843 1986 688751 SGTC_2845 9003024 42.97 µM 0.216161274401571 0.373483401922282 no 1263 0.414431019233093 1997 2990173 SGTC_2321 7390090 138.78 µM 0.215886369122945 0.373581796290776 no 1264 0.41453816121783 1851 649046 SGTC_2549 cedrol 20.94 µM 0.215304969037162 0.373789918722124 no 1265 0.414764777872223 2025 6708665 A sedative which affects the nervous system. SGTC_3019 9081971 49.47 µM 0.215249825839293 0.373809660115827 no 1266 0.41478627292246 2022 16451803 SGTC_1081 sertraline 6 µM 0.214260496653927 0.374163898479696 no 1267 0.41517196088725 2042 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2172 5754775 163.918 µM 0.212734362650993 0.374710553049429 no 1268 0.415767081335518 1870 2263357 SGTC_2975 9084847 53.72 µM 0.211431278645739 0.375177511475262 no 1269 0.416275375774269 1877 27211724 SGTC_3352 9151559 45.5865 µM 0.208561199403606 0.37620664508932 no 1270 0.417395401403621 1916 17159339 SGTC_1404 3909-7820 48.3 µM 0.208192080339269 0.376339065387833 no 1271 0.417539496044053 2056 23741373 SGTC_1160 4092-0570 10.5 µM 0.207986051208735 0.376412984018802 no 1272 0.41761992936296 1853 4994975 SGTC_1709 st033179 39.1045 µM 0.207304734596552 0.376657457402117 no 1273 0.417885938395265 1946 573381 SGTC_979 1426-2828 121 µM 0.206042645143397 0.377110457201738 no 1274 0.418378799953104 1998 747872 SGTC_197 4544-0043 41.561 µM 0.205856384121002 0.377177325921617 no 1275 0.418451548061208 2051 896523 SGTC_909 3448-9333 149 µM 0.205021446575851 0.377477118274376 no 1276 0.418777684491234 1879 3344074 SGTC_1567 st069303 68.4 µM 0.203298806994226 0.378095881729001 no 1277 0.419450743969499 1927 5581319 SGTC_3310 9130229 44.1445 µM 0.201836602119024 0.378621343885622 no 1278 0.420022233010906 2027 7761258 SGTC_597 k018-0003 82.8 µM 0.201587790629946 0.378710779874713 no 1279 0.42011949547084 2018 6786234 SGTC_1461 k072-0203 53.8 µM 0.200887370256041 0.378962582813814 no 1280 0.42039332174085 2054 5418714 SGTC_1717 st033143 58.0435 µM 0.200662459415367 0.379043449746097 no 1281 0.420481257825656 2043 674616 SGTC_1371 2421-0008 32.7 µM 0.199043283688817 0.379625782153203 no 1282 0.421114443222171 1913 2827552 SGTC_3036 9090181 49.47 µM 0.198091873818762 0.379968081764196 no 1283 0.421486591304965 1947 25236586 SGTC_2198 6589944 200 µM 0.196781934310661 0.380439527537631 no 1284 0.421999094513038 2002 5290268 SGTC_2343 7990716 14.84 µM 0.196484228362786 0.380546696376019 no 1285 0.422115588007062 1999 6456862 SGTC_81 0411-0046 9.971 µM 0.196454151619804 0.380557523977786 no 1286 0.422127357532609 1987 12925265 SGTC_573 3702-0553 84.7 µM 0.194352117313213 0.381314485864041 no 1287 0.422950089910848 1959 1222756 SGTC_2658 polymyxin b sulfate 77.05 µM 0.192711914309884 0.381905453745246 no 1288 0.423592296045395 1969 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.189512501874131 0.383058998524289 no 1289 0.424845578780437 2027 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1986 st071812 45 µM 0.189393103609134 0.383102067593303 no 1290 0.424892364590531 2050 11838594 SGTC_601 0986-0029 62.9 µM 0.189274648766413 0.383144797781194 no 1291 0.424938781769252 1970 24747981 SGTC_2886 9058944 51.95 µM 0.188559329572912 0.38340286490825 no 1292 0.425219105607319 2029 4949929 SGTC_1613 st002381 52.1 µM 0.187693882596904 0.383715163094708 no 1293 0.425558313012664 2113 551167 SGTC_2168 5727979 200 µM 0.18676017140967 0.384052179269381 no 1294 0.425924338006762 2060 695210 SGTC_198 3454-2873 16.191 µM 0.184793691711826 0.38476225218963 no 1295 0.426695427965605 1974 710957 SGTC_479 n-linoleoylglycine 10 µM 0.18353226298668 0.385217943170767 no 1296 0.427190203239837 1972 6433346 An anti-infammatory. SGTC_3120 9124077 49.47 µM 0.181741328052161 0.385865190414909 no 1297 0.427892865472229 2109 18774327 YGL155W CDC43 SGTC_1776 st049249 45.9 µM 0.181687070656841 0.38588480410922 no 1298 0.427914156606273 1927 1822314 SGTC_1471 k673-0312 37 µM 0.180664516274591 0.38625450534966 no 1299 0.428315456158981 2091 24099884 SGTC_924 2046-0044 21.3 µM 0.179545433346818 0.386659224550851 no 1300 0.428754723115524 2116 3623589 SGTC_1415 3966-0071 78.1 µM 0.178985118293191 0.386861910274157 no 1301 0.428974693441619 2058 2893185 SGTC_729 4092-0585 94.1 µM 0.1786124316377 0.386996741279016 no 1302 0.429121016215438 1929 2169061 SGTC_37 0566-0070 1.56 µM 0.17796546560038 0.387230833769255 no 1303 0.429375048604754 2069 1626686 SGTC_3330 9141424 71.43 µM 0.175666677659303 0.388062938179265 no 1304 0.430277907765218 2094 27261020 SGTC_2936 9038235 15.59 µM 0.174270756579467 0.388568478276453 no 1305 0.430826340211207 2056 4749415 SGTC_633 0437-0093 97.7 µM 0.173546512423938 0.388830841517311 no 1306 0.431110935435744 2024 2831118 SGTC_1377 2944-0135 198 µM 0.173228014509936 0.388946235996327 no 1307 0.431236102056617 1995 1894137 SGTC_1144 3486-0183 12.5 µM 0.173171535221001 0.38896669994184 no 1308 0.431258298595911 2000 6744069 SGTC_661 1304-0007 33.6 µM 0.173139770861767 0.388978209147658 no 1309 0.431270782185003 1968 3117130 SGTC_2360 9040895 200 µM 0.172627925008561 0.389163680094047 no 1310 0.431471950220342 1979 4914414 SGTC_408 cantharidin 100 µM 0.172218334386302 0.389312116332433 no 1311 0.431632942235872 2011 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2047 4141938 200 µM 0.170920733715935 0.389782475255909 no 1312 0.432143046705005 1990 3807862 SGTC_398 bronopol 33.3 µM 0.168679282029027 0.390595344651921 no 1313 0.433024457898151 2018 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1904 st060225 78 µM 0.168510877344056 0.390656436497618 no 1314 0.433090693574611 2087 66595 SGTC_1016 4226-1401 38 µM 0.167868164940714 0.390889616844211 no 1315 0.433343497690553 2104 2901613 SGTC_1932 st074806 40.9 µM 0.167514199629832 0.391018054579813 no 1316 0.433482737850532 2041 17251235 SGTC_214 4373-3496 70 µM 0.166899460762899 0.391241143290864 no 1317 0.433724578723578 2071 3779166 SGTC_2332 7982454 138.89 µM 0.164855264349551 0.391983239055401 no 1318 0.434528952202314 2102 2981748 SGTC_858 0438-0351 2.77 µM 0.163586878535878 0.392443893473697 no 1319 0.435028187478298 2000 2799119 SGTC_9 0092-0002 10.449 µM 0.162996348380329 0.392658414641766 no 1320 0.435260654896699 2097 759368 SGTC_881 0833-0569 170 µM 0.160800069796783 0.393456539801268 no 1321 0.436125435130902 1915 5418700 SGTC_854 0422-0053 192 µM 0.160327410166094 0.393628362461035 no 1322 0.436311583982865 2114 3596728 SGTC_1448 4255-0083 152 µM 0.158831223793353 0.394172397077761 no 1323 0.436900924019106 2100 5399660 SGTC_3196 9111891 49.47 µM 0.156265208722754 0.395105916947576 no 1324 0.437911989411039 2134 18891510 SGTC_769 0302-0231 76 µM 0.155367284735598 0.395432725504743 no 1325 0.438265886973806 2116 571869 YER009W NTF2 SGTC_939 1165-0479 45.3 µM 0.154344659638386 0.39580500986934 no 1326 0.4386689929369 2154 1377347 SGTC_421 streptovitacin 30 mM 0.151882647336164 0.396701689280016 no 1327 0.439639747460287 1991 91467 include heat shock SGTC_337 1315-0038 354 µM 0.151608351928889 0.396801623208393 no 1328 0.439747922837133 2038 1626437 SGTC_575 k072-0246 11.9 µM 0.150465328354739 0.397218133399695 no 1329 0.440198751624463 2090 6796779 SGTC_3332 9141069 11.198 µM 0.148471610691939 0.397944911203621 no 1330 0.440985294503882 1997 17332883 SGTC_627 1391-0720 175 µM 0.14846242000263 0.397948262344296 no 1331 0.44098892087037 2043 997839 SGTC_1123 mangostin 811.285 nM 0.148179580938475 0.398051395774392 no 1332 0.441100522980967 1992 5281650 An antioxidant. SGTC_72 0744-0168 198.391 µM 0.148151359266516 0.398061686815423 no 1333 0.441111658892458 2027 677577 SGTC_817 1391-0715 46 µM 0.147184062141126 0.398414454823079 no 1334 0.441493370078688 2005 1353946 SGTC_1526 st051518 75 µM 0.146297284019287 0.398737930949096 no 1335 0.441843354914992 1991 673993 SGTC_1418 3966-3099 2.4 µM 0.145546377408406 0.399011898703294 no 1336 0.442139750839831 2117 740335 SGTC_926 2268-1401 59.4 µM 0.144758679339959 0.399299343268155 no 1337 0.442450703806387 2162 2931578 SGTC_1611 st001856 99.4 µM 0.143904424423243 0.399611137287052 no 1338 0.442787970935774 1984 647478 SGTC_2585 alliin 100 µM 0.143074823795198 0.399913994040096 no 1339 0.443115544029315 2086 87310 A garlic compound which reacts with lipids. SGTC_174 3553-0389 74.3 µM 0.142635956837906 0.400074232629293 no 1340 0.443288849183251 2095 738071 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.142538962187861 0.400109649473435 no 1341 0.443327153082437 2151 688662 SGTC_1857 st056007 79.3 µM 0.140331481908794 0.40091591535452 no 1342 0.444199045729908 2165 619834 SGTC_1721 st082152 9.2685 µM 0.140225341513998 0.400954693016561 no 1343 0.444240975041662 2151 5296051 SGTC_2106 5357045 167.29 µM 0.140182450976052 0.400970363055995 no 1344 0.444257918539323 2119 668842 SGTC_3013 9080133 71.4286 µM 0.139125042840755 0.40135673698281 no 1345 0.444675669669998 2112 17050193 SGTC_1750 st081859 2.357 µM 0.138508730195819 0.401581980397953 no 1346 0.444919185210668 2069 5291695 SGTC_1107 amlodipine 47 µM 0.137985869688166 0.401773095559972 no 1347 0.44512579253553 2114 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.137451251202878 0.401968532771568 no 1348 0.445337061415539 2030 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3028 9087778 49.47 µM 0.137434787998163 0.40197455151401 no 1349 0.445343567540588 2118 17217395 SGTC_1428 4049-0204 61.7 µM 0.13424908577606 0.403139640354109 no 1350 0.446602806173142 2162 X1428 SGTC_1348 1493-0373 93.8 µM 0.133702063671102 0.403339786494223 no 1351 0.446819086622051 2115 3010129 SGTC_505 gw-5074 63.9 µM 0.132864828744997 0.403646165618772 no 1352 0.447150141417569 2140 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2354 9060492 162 µM 0.132835357396981 0.403656951490823 no 1353 0.447161795487051 2140 6471895 SGTC_2822 7994718 71.43 µM 0.132817427710124 0.403663513401894 no 1354 0.447168885575845 2171 1018011 SGTC_413 propylparaben 100 µM 0.131877576442635 0.404007518315557 no 1355 0.447540562553218 2040 7175 A pharmaceutical preservative. SGTC_3317 9138495 8.753 µM 0.13043743098683 0.404534785177323 no 1356 0.448110176949937 2187 17020139 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.130121158992395 0.404650602114637 no 1357 0.448235284992014 2111 7104 SGTC_2326 6164455 177.58 µM 0.128607899185809 0.405204864369189 no 1358 0.448833957787455 2074 2888790 SGTC_2784 7567673 72.73 µM 0.124819813029506 0.406593159753675 no 1359 0.450333100766363 2187 3471247 SGTC_3089 9117425 49.47 µM 0.124764006628714 0.406613621060912 no 1360 0.450355191617091 2025 9401657 SGTC_823 0417-1665 178 µM 0.12366555457008 0.407016418182682 no 1361 0.450790042863243 2097 3429856 SGTC_1995 st072814 61.1 µM 0.123399685858612 0.407113925770878 no 1362 0.450895302910701 2027 5769371 SGTC_1874 staurosporine 7.6 µM 0.122228899159107 0.407543381260398 no 1363 0.451358869912101 2168 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1074 carmofur 3.8 µM 0.121398555893514 0.40784802631502 no 1364 0.451687680325855 2186 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_166 k072-0058 166.424 µM 0.119564368458168 0.40852116951293 no 1365 0.452414123517353 2218 5846229 SGTC_719 2810-4230 27.3 µM 0.117310667058103 0.409348643015474 no 1366 0.453306936154092 2182 721079 SGTC_1958 st076513 41.9 µM 0.114085445049134 0.410533523993403 no 1367 0.454585030027923 2120 732122 YGL099W LSG1 SGTC_1897 st060201 15 µM 0.11166673936162 0.411422644018066 no 1368 0.45554382624421 2034 611878 SGTC_1504 k297-0033 30 µM 0.108784367154702 0.412482802598558 no 1369 0.456686761714295 2074 4388117 SGTC_1561 5-methoxyflavone 52.9 µM 0.107756078398502 0.412861170088348 no 1370 0.457094592154587 2223 94525 SGTC_3274 9138298 49.47 µM 0.106262578285762 0.413410860124122 no 1371 0.45768701081992 2223 17015756 SGTC_711 k292-0785 179 µM 0.106174006544422 0.413443464730489 no 1372 0.457722147062992 2186 4146315 SGTC_905 2-aminofluorene 215 µM 0.105143123256809 0.41382299240702 no 1373 0.458131120755042 2231 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1814 st052110 31.539 µM 0.104841002175605 0.413934235896791 no 1374 0.4582509871401 2213 674163 SGTC_1200 1643-0193 18.4 µM 0.104422193900774 0.414088456000943 no 1375 0.458417155387088 2233 5403974 SGTC_253 dyclonine 31.25 µM 0.103862410879899 0.414294608706134 no 1376 0.458639268748877 2205 3180 An oral anasthetic. SGTC_2096 5468907 200 µM 0.10352043249891 0.41442056157047 no 1377 0.458774966911681 2205 759785 SGTC_2762 leflunomide 42.06 µM 0.103436725880828 0.414451392604123 no 1378 0.458808182709537 2131 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_179 1273-0063 6.77 µM 0.102279727999467 0.41487759490785 no 1379 0.459267322813202 2139 3108139 SGTC_64 000l-0018 272.079 µM 0.101451973034563 0.415182575808805 no 1380 0.459595840371782 2067 6811119 SGTC_642 0335-0876 158 µM 0.101029801620309 0.41533814179882 no 1381 0.459763401466155 2143 6812350 SGTC_2196 6573537 42.6665 µM 0.100496648028641 0.415534622585662 no 1382 0.459975021926427 2237 2903087 SGTC_277 nystatin 15.5 µM 0.100344071128293 0.415590854979866 no 1383 0.46003558516441 2229 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_111 0083-0039 52.457 µM 0.100098669757804 0.415681301566148 no 1384 0.460132995704545 2237 759313 SGTC_986 1493-0483 84 µM 0.0995978860970661 0.415865887220102 no 1385 0.460331786066132 2224 40079 SGTC_10 0279-0212 42.575 µM 0.0988634016746126 0.416136647047725 no 1386 0.460623363867784 2229 39851 YBR002C RER2 SGTC_2223 6903751 107.57 µM 0.09419928195122 0.417856948717612 no 1387 0.462475427579577 2204 5598863 SGTC_213 1246-0773 967 nM 0.0934557001562922 0.418131355705518 no 1388 0.462770770882406 2170 6251622 SGTC_666 0272-0154 136 µM 0.0905332583422331 0.419210221119441 no 1389 0.463931733061872 2166 6870312 SGTC_3195 9113082 49.47 µM 0.0893655504772685 0.419641469247648 no 1390 0.464395700317169 2260 17018038 SGTC_3351 9150312 21.596 µM 0.0864816577771634 0.420706936977518 no 1391 0.465541768205999 2263 4904905 SGTC_1373 2887-0003 58.5 µM 0.0851101097904476 0.421213866233154 no 1392 0.466086926511019 2181 776948 SGTC_863 0466-0191 129 µM 0.0838839205964007 0.421667180964905 no 1393 0.466574362001538 2271 765160 YPR165W RHO1 SGTC_2816 7982706 58.44 µM 0.0837052810327956 0.421733231610682 no 1394 0.466645379113573 2176 2981853 SGTC_1245 0418-0076 17.2 µM 0.0834051925734974 0.421844192034897 no 1395 0.466764679911774 2181 6790114 SGTC_1328 1441-0025 69.2 µM 0.0831667006144613 0.42193238102133 no 1396 0.4668594950218 2242 4562601 SGTC_2512 diallyl trisulfide 49.23 µM 0.0829205981040928 0.422023388323495 no 1397 0.466957337762044 2272 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2143 5623677 140.463 µM 0.0828833937928516 0.42203714662766 no 1398 0.466972129218453 2252 5375313 SGTC_795 0685-0265 78 µM 0.0823088861332758 0.42224961394313 no 1399 0.467200544143506 2291 302754 SGTC_334 1502-1024 68.5 µM 0.0818320436276785 0.422425979427005 no 1400 0.467390137194108 2169 3296216 SGTC_2777 climbazole 1.536 µM 0.0801861829375725 0.42303483851583 no 1401 0.468044589596239 2282 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1149 3909-7961 23.3 µM 0.079679380056894 0.423222358999879 no 1402 0.468246129816123 2109 735261 SGTC_1281 0884-0031 11.8 µM 0.0761965747919156 0.424511488739852 no 1403 0.469631353844596 2236 1548255 SGTC_2268 7933382 153.85 µM 0.0756119958904569 0.42472794503753 no 1404 0.469863896223631 2291 935025 YOR257W CDC31 SGTC_3125 9127534 49.47 µM 0.0730654093018758 0.425671152247519 no 1405 0.470877033718536 2296 1639235 SGTC_754 3474-0146 171 µM 0.0727223040190489 0.425798264557988 no 1406 0.471013549749656 2218 24762078 SGTC_2058 5236698 133 µM 0.0726270937211625 0.425833539066135 no 1407 0.471051432988504 2230 766665 SGTC_66 0109-0187 42.4 µM 0.0718995969502465 0.426103089261138 no 1408 0.471340905404156 2305 759417 SGTC_2171 5739187 198.077 µM 0.0679888491804663 0.427552677895133 no 1409 0.472897255404904 2271 2262761 SGTC_2304 7443016 91.4 µM 0.0679423114260757 0.427569933876785 no 1410 0.472915778451379 2276 939854 SGTC_1963 st076565 50.3 µM 0.067862809956515 0.42759941297035 no 1411 0.472947421914608 2279 4914280 SGTC_2404 5161160 200 µM 0.0675498245034928 0.42771547170056 no 1412 0.473071999176831 2245 2831543 SGTC_2034 5197015 53.07 µM 0.067549804372107 0.427715479165719 no 1413 0.473072007189789 2255 780676 SGTC_318 1488-0629 67.2 µM 0.0667708050353355 0.428004368526194 no 1414 0.473382082865488 2192 3662576 SGTC_2734 clemastine 41.6 µM 0.0657992787949062 0.428364709924931 no 1415 0.473768815215963 2296 26987 Clemastine is a selective histamine H1 antagonist. SGTC_957 1187-1561 14.1 µM 0.0650890797703143 0.428628162248045 no 1416 0.474051537538257 2293 1538454 SGTC_418 lividomycin a 100 µM 0.0647478565099533 0.428754752255265 no 1417 0.474187379374984 2302 72394 An antibiotic. SGTC_948 3448-0295 75.3 µM 0.063719514448021 0.429136299919415 no 1418 0.474596783019581 2296 678569 SGTC_885 0865-0106 16.8 µM 0.0634511598589544 0.429235878930374 no 1419 0.474703624806767 2261 2793380 SGTC_668 1682-0499 62.6 µM 0.0626440353596062 0.429535407761436 no 1420 0.475024981554807 2222 682214 SGTC_743 1275-0778 158 µM 0.0610165442018547 0.430139502876618 no 1421 0.475673016618502 2294 2849257 YMR203W TOM40 SGTC_3027 9089541 49.47 µM 0.0607762224231603 0.430228719843033 no 1422 0.475768713532332 2238 9943819 SGTC_3229 9132204 49.47 µM 0.0600365811262495 0.43050332633204 no 1423 0.476063249849094 2220 17682924 SGTC_2151 5563267 85.4165 µM 0.0588339217647689 0.43094990915436 no 1424 0.4765421947927 2211 5310824 SGTC_2984 9022109 38.96 µM 0.0587525135496546 0.43098014161828 no 1425 0.476574615889152 2302 6459207 SGTC_281 1672-3440 14.9 µM 0.058486763046054 0.43107883585445 no 1426 0.476680453002437 2285 6833000 SGTC_1196 1588-0294 184 µM 0.0584551801016583 0.431090565392509 no 1427 0.476693031254301 2213 6144269 SGTC_594 1487-1584 10.8 µM 0.0573675875089393 0.431494521640432 no 1428 0.477126190942771 2278 5013332 SGTC_3046 9092212 49.47 µM 0.0568958444250504 0.431669759893671 no 1429 0.477314082310513 2302 25236637 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0561922736051871 0.43193114009686 no 1430 0.477594318104542 2296 3256 An antibiotic and ribosome inhibitor. SGTC_1441 4106-0040 13 µM 0.056011377278757 0.431998348839546 no 1431 0.477666371816696 2304 2904180 SGTC_1113 artemisinin 1.17947 µM 0.0555445393398566 0.432171803080762 no 1432 0.477852323716852 2319 2240 An anti-malaria and mitochondrial poison. SGTC_789 1309-1135 70.6 µM 0.0547146519597704 0.432480181072197 no 1433 0.478182898136537 2316 3092424 SGTC_47 0149-0135 24.25 µM 0.0537594685381412 0.432835168748289 no 1434 0.4785634011078 2309 5239155 SGTC_2583 asiatic acid 100 µM 0.0536447268245427 0.432877815409065 no 1435 0.478609110470147 2277 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3199 9111318 49.47 µM 0.052685941217815 0.433234202850194 no 1436 0.47899107037536 2297 8548020 SGTC_1594 piperine 70.1 µM 0.0524859208603587 0.433308558697644 no 1437 0.47907075669905 2317 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2832 7992762 51.95 µM 0.0521433422126816 0.433435914846138 no 1438 0.479207238913788 2233 2985177 SGTC_1694 st024011 44.9 µM 0.051265287482034 0.433762369724431 no 1439 0.479557064146251 2318 2787533 SGTC_1492 4158-0558 28.5 µM 0.0508855163103135 0.433903580119281 no 1440 0.479708373433832 2304 3967268 SGTC_1028 k015-0029 4.8 µM 0.0493769024008428 0.43446461149034 no 1441 0.480309467459276 2321 4588309 SGTC_1109 tnp00067 928.257 nM 0.0488592969640303 0.43465713182809 no 1442 0.480515713207188 2211 676295 SGTC_1712 st032288 53.4 µM 0.0487190395459796 0.434709302430771 no 1443 0.480571601264254 2299 2883011 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0486016396934335 0.434752971733587 no 1444 0.480618381612399 2329 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2055 5235184 200 µM 0.0466356764567734 0.435484370278166 no 1445 0.481401798626118 2292 2836034 SGTC_2085 5307070 144.047 µM 0.0426732317538572 0.436959189425705 no 1446 0.482981009045819 2307 2840351 SGTC_2348 9022543 33.42 µM 0.0422216046396612 0.43712734075288 no 1447 0.483161019951725 2285 3162678 YDL140C RPO21 SGTC_1058 3448-5425 97.3 µM 0.0420814984905135 0.437179507855685 no 1448 0.483216864585207 2328 7279705 SGTC_3257 9139206 32.98 µM 0.0419430378916988 0.437231063327603 no 1449 0.48327205364551 2320 4910041 SGTC_3307 9126885 69.2785 µM 0.0416540193092488 0.437338682137179 no 1450 0.483387254698643 2307 24824909 SGTC_1249 0481-0015 10.2 µM 0.0402803760049601 0.437850234494757 no 1451 0.483934799379854 2315 4227577 SGTC_1258 0671-0043 57.1 µM 0.0401649837475406 0.437893211950924 no 1452 0.483980797006139 2304 4298767 SGTC_2800 7887935 81.82 µM 0.0393845781655247 0.438183890578545 no 1453 0.484291887605599 2281 2961002 SGTC_3159 9100096 49.47 µM 0.0386538493703648 0.438456096273053 no 1454 0.484583184377066 2345 25236875 SGTC_1168 k815-0004 80.5 µM 0.0384731075214253 0.438523429388454 no 1455 0.484655236346674 2326 642433 SGTC_1755 st041960 45.185 µM 0.0384197222470988 0.438543317745253 no 1456 0.484676518255258 2301 2257073 SGTC_1307 1187-1599 12.2 µM 0.0383839648972642 0.438556639013598 no 1457 0.484690772859421 2286 1538471 SGTC_803 4488-1585 147 µM 0.0375687694997525 0.438860355895837 no 1458 0.485015754331906 2331 747204 SGTC_1948 st076329 66.6 µM 0.0373571510182156 0.438939204365576 no 1459 0.48510011866902 2347 24208413 SGTC_2759 disulfiram 3.38 µM 0.0372535881800512 0.438977792480232 no 1460 0.485141405524562 2318 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1143 3454-2408 5.08 µM 0.0367473454060707 0.439166429816465 no 1461 0.485343228970168 2335 X1143 SGTC_3033 9090887 49.47 µM 0.0351294555259535 0.439769384059081 no 1462 0.485988256894631 2331 19325384 SGTC_538 2922-0838 53.3 µM 0.0347091549379902 0.439926044355013 no 1463 0.486155830371244 2343 777039 SGTC_2319 6033012 152.6 µM 0.0345418884994168 0.439988392852366 no 1464 0.486222520035609 2324 847246 SGTC_2682 pyrogallin 40.03 µM 0.0338142029150413 0.440259654660925 no 1465 0.486512655067165 2358 822798 An ATP competetive kinase inhibitor. SGTC_2445 5742597 35.57 µM 0.0327380774730093 0.440660856931119 no 1466 0.486941729361235 2305 1774255 SGTC_2656 pseudo-anisatin 100 µM 0.0327048111629962 0.440673260286204 no 1467 0.486954993595949 2340 6708809 A neurotoxin. SGTC_3085 9117376 49.47 µM 0.0320059238092169 0.440933854113402 no 1468 0.487233663401257 2246 16480349 SGTC_630 4356-0227 183 µM 0.0313133373325213 0.441192123769552 no 1469 0.487509826985613 2353 779312 SGTC_2366 9070441 60.58 µM 0.0308597822344862 0.441361270748777 no 1470 0.487690681881293 2356 6837235 SGTC_1263 0774-1208 64.8 µM 0.0305861675121945 0.4414633166763 no 1471 0.487799786857904 2343 906585 SGTC_779 1360-0071 233 µM 0.0292935125172574 0.441945471010964 no 1472 0.488315250472453 2350 7566 SGTC_927 2425-1185 123 µM 0.0278143218499739 0.442497307791794 no 1473 0.488905121598943 2357 730375 SGTC_2250 alverine citrate 130 µM 0.0277919266664581 0.442505663549215 no 1474 0.48891405253199 2341 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_379 3970-0972 5.9 µM 0.0273838111832826 0.442657937997803 no 1475 0.489076805105881 2320 2898042 YBL034C STU1 SGTC_1472 k841-0093 193 µM 0.0271679500839005 0.44273848267138 no 1476 0.489162889196846 2342 X1472 SGTC_2200 6600604 21.907 µM 0.0262916117884281 0.443065496763444 no 1477 0.489512372711664 2352 2904777 SGTC_3117 9124945 49.47 µM 0.0257187477578704 0.443279287482969 no 1478 0.489740835127122 2347 17592065 SGTC_923 1900-2434 73.3 µM 0.025549361495268 0.443342504970296 no 1479 0.48980838827052 2361 5910570 SGTC_838 0109-0203 71.4 µM 0.0255485143726724 0.443342821132748 no 1480 0.489808726113259 2354 759422 SGTC_1051 3253-3903 78 µM 0.0255145845455011 0.443355484426721 no 1481 0.4898222577448 2354 5509239 SGTC_1610 st001799 48.1 µM 0.025459598466228 0.443376006460347 no 1482 0.489844186892999 2353 621897 SGTC_928 2764-0428 58.7 µM 0.0244580098095135 0.443749848255839 no 1483 0.49024363850209 2277 662578 SGTC_1949 st076024 69.1 µM 0.0236888592645769 0.444036966800007 no 1484 0.490550396266318 2351 2921930 SGTC_3035 9091303 49.47 µM 0.0232555419012049 0.444198734101094 no 1485 0.490723217268125 2367 25237002 SGTC_818 4072-2707 53.5 µM 0.022052608076692 0.444647865508253 no 1486 0.491202995273789 2370 882871 SGTC_3122 9126309 49.47 µM 0.0213121860110811 0.444924347349341 no 1487 0.491498311508229 2374 17591206 SGTC_604 1000-0114 314 µM 0.0203272651043081 0.445292169285936 no 1488 0.491891152934977 2366 1572745 SGTC_506 n9-isopropylolomoucine 153 µM 0.0194068281237619 0.44563595207242 no 1489 0.492258281690079 2374 6610355 SGTC_1093 fluphenazine 7.97 µM 0.0179994121581097 0.446161700243505 no 1490 0.492819661182823 2372 6602611 An atypical antipsychotic. SGTC_449 xestospongin c 11.1929 µM 0.0160936820166878 0.446873747194777 no 1491 0.493579826941937 2370 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2576 guaiol 23.12 µM 0.0153742568109994 0.447142594095027 no 1492 0.49386680054441 2372 227829 SGTC_1697 st025554 27.742 µM 0.0146536011737126 0.447411925156954 no 1493 0.494154268139493 2378 1269519 SGTC_1771 st048882 4.1505 µM 0.014608927229271 0.447428621976447 no 1494 0.494172088557217 2370 4580403 SGTC_693 4161-2696 114 µM 0.0141952880844532 0.447583223405264 no 1495 0.494337089586535 2376 805759 SGTC_1385 3091-4834 14.1 µM 0.0118529198471957 0.448458854603673 no 1496 0.49527147984665 2369 4072814 SGTC_2141 5621638 7.665 µM 0.0117738445424408 0.448488419180257 no 1497 0.49530302412787 2381 2856238 SGTC_205 1486-1330 71.903 µM 0.0117563598841097 0.448494956361192 no 1498 0.495309999014596 2379 4118834 SGTC_3290 9121031 71.43 µM 0.0115288153909502 0.448580032190584 no 1499 0.495400769981191 2381 17014854 SGTC_2325 6158266 200 µM 0.0112823290733919 0.448672192781689 no 1500 0.495499097398785 2367 3623240 SGTC_3294 9122953 26.2835 µM 0.0109555840834272 0.44879436614971 no 1501 0.49562944173205 2380 16459826 SGTC_493 zm226600 134 µM 0.0100594507245322 0.449129464669255 no 1502 0.495986927470656 2383 5240098 A potassium channel opener. YCR052W RSC6 SGTC_384 k007-0144 5.16 µM 0.00989173247943423 0.449192184971015 no 1503 0.496053834040642 2375 6824886 SGTC_2856 9022925 19.48 µM 0.00909492094331552 0.449490179767826 no 1504 0.496371701519554 2382 4944862 SGTC_2691 st077356 60.2 µM 0.00772713615231418 0.450001775781409 no 1505 0.496917349359263 2378 2839272 SGTC_383 2324-0395 7.37 µM 0.00725886688846357 0.45017694286004 no 1506 0.497104156521295 2381 3146421 SGTC_833 3852-0053 558 µM 0.00532712176491858 0.45089965958383 no 1507 0.497874795946719 2388 3123681 SGTC_1514 1189-1591 158 µM 0.00449527671514605 0.451210925014951 no 1508 0.498206650096083 2393 767698 YMR146C TIF34 SGTC_1879 gemcitabine 100 µM 0.00412286416186558 0.451350286607773 no 1509 0.498355219829146 2396 60750 A nucleoside analog which inhibits DNA replication. SGTC_2289 7946404 165.07 µM 0.00399546990549245 0.451397960563065 no 1510 0.49840604236556 2395 1246120 YPR165W RHO1 SGTC_660 4031-1742 102 µM 0.00347557943719356 0.451592523179861 no 1511 0.498613447205123 2400 6738706 SGTC_1939 st074455 53.6 µM 0.0029085044416948 0.451804757283687 no 1512 0.498839676241413 2399 1644229 SGTC_680 0417-1641 114 µM 0.00247606569952325 0.451966611537706 no 1513 0.499012193712766 2400 2835990 SGTC_1761 st044296 37 µM 0.00173449164087766 0.452244188301178 no 1514 0.499308038296408 2402 1826700 SGTC_32 0928-0142 34.1 µM 0.000714863516390297 0.452625880885649 no 1515 0.499714810742885 2405 2244242 SGTC_2405 ticlatone 3.52 µM 0.000275433243549512 0.452790392886438 no 1516 0.499890118035109 2404 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2219 9098279 200 µM 0 0.452893512523738 no 1517 0.5 2405 902349 SGTC_2894 9048625 32.47 µM -3.12606738882139e-05 0.452905216429337 no 1518 0.499987528795474 2406 4092861 SGTC_1980 st071811 45.7 µM -0.000628407225561824 0.45312879420928 no 1519 0.499749301804914 2407 4974850 SGTC_3298 9116858 71.43 µM -0.00159863499556719 0.453492089068229 no 1520 0.499362237180987 2410 2506942 SGTC_3348 9149464 3.537 µM -0.00165990187182629 0.453515031322213 no 1521 0.499337795266104 2407 1951442 SGTC_2989 9073649 71.4286 µM -0.00176729666092869 0.453555247204084 no 1522 0.499294951006961 2410 21367202 SGTC_969 1313-0238 134 µM -0.00236434708177608 0.453778831986891 no 1523 0.49905676286234 2406 5212874 SGTC_1227 3909-8010 46.6 µM -0.00251687590075527 0.453835953673842 no 1524 0.498995912848758 2414 15982272 SGTC_2314 7727897 200 µM -0.00534560709085724 0.45489547874421 no 1525 0.497867421473636 2421 900724 SGTC_1833 st055984 71 µM -0.0060003018961204 0.455140746206231 no 1526 0.497606240242477 2418 676288 SGTC_1407 3909-7909 12.3 µM -0.00699776606803456 0.455514457752934 no 1527 0.497208318031308 2426 4411780 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0081313699514544 0.455939223400128 no 1528 0.496756088476279 2405 2724 A muscle relaxant with antifungal properties. SGTC_2716 st080858 38.6235 µM -0.00825302073502322 0.455984809408111 no 1529 0.496707558463801 2419 5296050 SGTC_1070 indatraline 8.81 µM -0.0100521591287543 0.456659065057721 no 1530 0.495989836249433 2432 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_374 0880-0231 82.3 µM -0.0100663360947575 0.456664378598729 no 1531 0.49598418074443 2422 6833587 SGTC_624 k048-0052 28 µM -0.0108306270965796 0.456950847073463 no 1532 0.495679289399759 2430 6835531 SGTC_1624 st003710 6.25 µM -0.0120846740574985 0.457420932306027 no 1533 0.495179029915766 2422 24207033 SGTC_93 0109-0045 59.227 µM -0.0135160560836398 0.457957565172871 no 1534 0.49460803793512 2425 88733 SGTC_2744 captopril 92.04 µM -0.0136191555395045 0.457996220687641 no 1535 0.494566910988605 2433 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3053 9095903 49.47 µM -0.0136374018635504 0.458003061900428 no 1536 0.494559632434435 2426 17174018 SGTC_368 fentichlor 4.58 µM -0.0137603852155837 0.458049173171846 no 1537 0.494510573778936 2440 7329 A pesticide. SGTC_1926 methyl fluorone black 53.6 µM -0.0141559060822654 0.458197473247526 no 1538 0.494352799153815 2430 72721 Reacts with homocysteine. SGTC_1937 st074714 47.2 µM -0.0143424010084734 0.458267401317055 no 1539 0.494278405995494 2440 17250970 SGTC_884 0851-0618 334 µM -0.0151145496229625 0.458556939600903 no 1540 0.493970396683803 2438 9642473 SGTC_1094 duloxetine 25.4 µM -0.015496958997946 0.458700342627412 no 1541 0.493817855285317 2425 60834 A selective serotonin reuptake inhibitor. SGTC_311 1315-0136 58 µM -0.0165760741060148 0.459105038336124 no 1542 0.49338740601702 2440 6759207 SGTC_46 0329-0187a 2.197 µM -0.0167257513874232 0.459161174493577 no 1543 0.493327701698277 2425 46494817 SGTC_487 nimodipine 119 µM -0.0168290248039091 0.459199907451475 no 1544 0.493286507364132 2437 4497 L-type voltage-gated calcium channels inhibitor SGTC_2398 5228213 48.84 µM -0.0169925436704695 0.459261236410824 no 1545 0.493221282101742 2434 80771 YMR134W ERG29 SGTC_2638 epoxomicin 18 µM -0.0208415752154077 0.460705120993558 no 1546 0.491686016353353 2458 9915668 A protesome inhibitor. SGTC_109 0132-0036 33.701 µM -0.0209962937193198 0.460763171402209 no 1547 0.491624306104379 2435 67274 A color developer. SGTC_2224 6650123 117.647 µM -0.0220926719903543 0.461174556599417 no 1548 0.491187015977754 2437 2908370 SGTC_1302 1159-0335 255 µM -0.0224632787236775 0.461313625800619 no 1549 0.491039201968478 2449 649284 SGTC_2239 6685329 187.64 µM -0.0234046205594977 0.461666883077076 no 1550 0.490663759671651 2540 805680 SGTC_2115 tiliquinol 12.7705 µM -0.024332450601383 0.462015099381966 no 1551 0.490293714475868 2495 71208 A bioactive hydroxyquinoline. SGTC_3163 9099914 49.47 µM -0.0246129894519695 0.462120391868799 no 1552 0.490181829177295 2447 16268368 SGTC_2135 5326629 150.42 µM -0.0250373907043341 0.46227968416657 no 1553 0.490012569739633 2468 5020077 SGTC_835 0312-0010 67.2 µM -0.0255836522088429 0.462484723684248 no 1554 0.489794712725266 2445 1626196 SGTC_287 k060-0039 29.6 µM -0.0261883493091036 0.462711708654237 no 1555 0.489553554300671 2460 5861974 SGTC_3204 9114183 49.47 µM -0.026214438009519 0.462721501835684 no 1556 0.489543149986997 2454 17027248 SGTC_1014 4130-3005 69.3 µM -0.0279569899137384 0.463375672173985 no 1557 0.488848227401336 2470 743608 SGTC_385 1494-0393 12.4 µM -0.0284040712052302 0.463543526722995 no 1558 0.488669938580272 2480 3090647 SGTC_2053 5265679 138 µM -0.0340867027750087 0.465677599185386 no 1559 0.486404005986275 2469 764595 SGTC_1217 1183-1422 255 µM -0.0341823871481421 0.465713541406158 no 1560 0.486365855676492 2499 2849664 SGTC_2634 4'-methoxyflavone 100 µM -0.0342244936388662 0.465729358087785 no 1561 0.486349067440009 2482 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1197 1601-0112 267 µM -0.0345248538373348 0.46584218553107 no 1562 0.486229311831547 2466 7350313 SGTC_3356 9151811 4.48 µM -0.0358598451504025 0.466343695378325 no 1563 0.485697057093505 2471 1859254 YPR165W RHO1 SGTC_2033 5192550 145 µM -0.0369239723809059 0.466743489320599 no 1564 0.485272812790999 2479 182073 SGTC_663 1486-0733 13.9 µM -0.0369985352835446 0.46677150395984 no 1565 0.485243086808372 2483 722445 YPR165W RHO1 SGTC_1458 k015-0034 6.33 µM -0.0373536431856535 0.4669049267166 no 1566 0.485101517115687 2496 3598957 SGTC_721 1187-1332 279 µM -0.0377128417402452 0.467039890215251 no 1567 0.4849583185266 2463 25730 SGTC_1252 0493-0875 34.8 µM -0.039608194320905 0.467752103063896 no 1568 0.484202747221863 2488 3960963 SGTC_134 0269-0018 6.916 µM -0.0398418989327345 0.467839928974408 no 1569 0.484109586108113 2514 4378915 SGTC_645 0845-0943 5.41 µM -0.039914312605212 0.467867142262829 no 1570 0.484080720193819 2500 1885106 SGTC_524 r073-0010 27.8 µM -0.0399324720327828 0.46787396665702 no 1571 0.484073481401545 2480 2772106 SGTC_2476 5806916 10.51 µM -0.0401713403545595 0.46796373532006 no 1572 0.483978263131844 2502 2870194 SGTC_2737 bleomycin 30.5 nM -0.0403480462641113 0.468030143890313 no 1573 0.483907824781306 2479 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_559 1550-0661 158 µM -0.0425971419280254 0.468875462824105 no 1574 0.483011336917531 2533 5830875 SGTC_1859 st055998 20 µM -0.0427277531372972 0.468924557181931 no 1575 0.482959277981288 2484 676301 SGTC_1632 st005650 90 µM -0.0432081188039579 0.46910512188392 no 1576 0.482767816632383 2534 2759605 SGTC_740 k014-0057 261 µM -0.0437924423211127 0.469324771876112 no 1577 0.482534925730286 2538 4012779 SGTC_1194 1488-0194 225 µM -0.0438208164424252 0.469335438081628 no 1578 0.482523616949726 2480 1391452 SGTC_804 1595-0054 20.9 µM -0.0441601564385475 0.469463002154047 no 1579 0.482388370803482 2493 761523 Stimulates phospholipase C. SGTC_2249 haloperidol 116.36 µM -0.0464341441585483 0.470317915713139 no 1580 0.481482111374973 2479 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3254 9136651 49.47 µM -0.0476995908776254 0.47079372430189 no 1581 0.480977830082864 2499 16454030 SGTC_2904 7225135 42.03 µM -0.0484316486744708 0.47106899747529 no 1582 0.480686118448462 2524 4446116 SGTC_1752 st044819 83.042 µM -0.0498533285368625 0.471603626232984 no 1583 0.480119634727565 2519 441209 YML126C ERG13 SGTC_2589 lobaric acid 100 µM -0.0509976581961652 0.472033993486339 no 1584 0.479663693305292 2515 73157 A novel microtubule depolymerizer. SGTC_503 tyrphostin 8 294 µM -0.0516282389024292 0.472271160538865 no 1585 0.479412458974673 2489 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_148 3253-0744 288.01 µM -0.0526076933449506 0.472639561594326 no 1586 0.479022243529122 2487 6893655 SGTC_1195 1502-0147 41.1 µM -0.0534026828826509 0.472938597304321 no 1587 0.478705533816908 2489 817940 SGTC_3006 9075424 71.4286 µM -0.0534263319509025 0.472947493147545 no 1588 0.478696112653088 2516 7465181 SGTC_2315 7733312 200 µM -0.0549857605016742 0.473534117998853 no 1589 0.47807490405171 2526 726316 SGTC_2020 4017018 200 µM -0.055272128908365 0.473641850161588 no 1590 0.47796083306098 2552 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_895 0964-0006 13.7 µM -0.0556811958112921 0.473795744998113 no 1591 0.477797889913855 2495 6738897 SGTC_39 0986-0283 58.349 µM -0.0568014586278645 0.474217218413618 no 1592 0.477351675999497 2534 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.056956009435996 0.474275366917437 no 1593 0.477290118802929 2498 1377 SGTC_1723 st034307 2.5525 µM -0.0574493398073456 0.474460982179426 no 1594 0.477093630194404 2550 867466 SGTC_355 1311-2252 105 µM -0.05868672871474 0.47492657333054 no 1595 0.476600815035 2529 5338538 SGTC_2617 dihydrotanshinone i 20.83 µM -0.0591308356667156 0.475093685416053 no 1596 0.476423949146631 2541 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2451 5856223 45.7 µM -0.0601773705646637 0.475487501142483 no 1597 0.476007184359116 2536 2179896 SGTC_1212 0520-0165 585 µM -0.0603442640699247 0.475550306133163 no 1598 0.475940724263704 2646 5403258 SGTC_1436 4092-1007 8.32 µM -0.0604734838796599 0.475598934260338 no 1599 0.47588926699364 2521 2881121 SGTC_3018 9082602 49.47 µM -0.060521404068898 0.475616967725982 no 1600 0.475870184556335 2522 17332089 SGTC_2162 5663267 200 µM -0.06145718627668 0.475969133986386 no 1601 0.47549755516053 2515 6456493 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.061692662455005 0.476057754544601 no 1602 0.475403791676555 2534 6708514 SGTC_1006 4099-6547 255 µM -0.062134962399483 0.476224215633363 no 1603 0.475227677404405 2572 3146833 SGTC_1401 3807-4679 7.6 µM -0.0628395127934681 0.476489384128222 no 1604 0.474947150684345 2515 3291456 SGTC_1314 1222-0010 41.1 µM -0.0633107273700043 0.476666738877859 no 1605 0.474759536847884 2561 3526027 SGTC_1053 3366-3204 134 µM -0.0645384733972824 0.477128856963487 no 1606 0.474270736804742 2554 3632071 YPR165W RHO1 SGTC_755 1995-0008 37.3 µM -0.0654277429273111 0.477463593259948 no 1607 0.473916717868201 2506 689533 SGTC_2082 5219693 150 µM -0.0656049702402601 0.477530306566631 no 1608 0.473846165980732 2511 2834649 SGTC_2371 9071574 200 µM -0.066752555260917 0.477962304752587 no 1609 0.473389347264902 2500 45596039 SGTC_3116 9124943 49.47 µM -0.0669196989963381 0.478025226699391 no 1610 0.473322815329428 2530 41905195 YPL160W CDC60 SGTC_2972 9093619 59.92 µM -0.067476879250742 0.478234983446018 no 1611 0.473101033875997 2533 25236256 SGTC_816 0325-0417 81.3 µM -0.067926032580058 0.478404076638584 no 1612 0.472922257802797 2567 68101 SGTC_2991 9074669 71.4286 µM -0.0688922934564224 0.478767858952076 no 1613 0.472537676438435 2584 17333109 SGTC_3151 9099821 49.47 µM -0.0705474468909761 0.479391039620308 no 1614 0.471878968718016 2620 17174189 SGTC_1042 0350-0096 82 µM -0.0707042985388621 0.479450098362394 no 1615 0.471816549831411 2514 3122515 SGTC_3166 9102297 49.47 µM -0.0710213621499756 0.479569482469459 no 1616 0.47169037694107 2572 25237072 SGTC_528 3492-0019 172 µM -0.0715524972539324 0.479769475115373 no 1617 0.471479022410342 2524 2869262 SGTC_1254 0550-0035 264 µM -0.072651695389023 0.480183381301277 no 1618 0.471041644202298 2606 15121435 SGTC_903 1134-0042 114 µM -0.0731640380717973 0.480376312724414 no 1619 0.4708377915621 2544 701009 SGTC_2873 9040596 71.43 µM -0.0732457444719712 0.480407081096732 no 1620 0.470805282648227 2646 6463863 SGTC_2860 9025725 38.96 µM -0.0738330781211938 0.480628258142172 no 1621 0.470571603155878 2557 40546248 SGTC_26 0302-0163 425.158 µM -0.0752492324384827 0.481161575372868 no 1622 0.470008206769631 2562 3100915 SGTC_231 b-estradiol 524 µM -0.0754722611399759 0.481245570058212 no 1623 0.469919483489589 2533 450 A steroid. SGTC_1668 st014914 51.6 µM -0.0758337285415082 0.481381703813396 no 1624 0.469775690939638 2553 2839556 SGTC_2414 st077232 92.9 µM -0.0762297971962919 0.481530871384053 no 1625 0.469618138459072 2546 729801 SGTC_1758 st042942 75.2445 µM -0.0789139463934169 0.482541844053199 no 1626 0.4685505351096 2527 669317 SGTC_1800 st050079 29.0735 µM -0.0790154750897639 0.482580086622508 no 1627 0.46851015710344 2566 3645560 SGTC_235 0330-0087 5 mM -0.079916543715258 0.482919496952599 no 1628 0.468151815966028 2558 46494818 YHR062C RPP1 SGTC_380 3970-0968 6 µM -0.0833577409902119 0.484215822887492 no 1629 0.466783544662206 2567 2891601 SGTC_1326 1431-2094 10.8 µM -0.0857727315602199 0.485125669178166 no 1630 0.465823541817922 2547 616278 SGTC_2298 7976326 193.81 µM -0.0865213402946212 0.485407723028075 no 1631 0.465525996289268 2607 2235818 SGTC_1961 st076550 68.7 µM -0.0883376980705727 0.486092103518257 no 1632 0.464804138665164 2655 1579337 SGTC_1465 k213-0056 144 µM -0.0891805681478253 0.486409700272477 no 1633 0.464469204104251 2543 24048857 YMR208W ERG12 SGTC_2787 5284540 71.43 µM -0.0900987706094427 0.486755692368154 no 1634 0.464104363079706 2633 736958 SGTC_1229 0139-0193 12.2 µM -0.0902203967991619 0.486801523645891 no 1635 0.464056038060948 2581 3090752 SGTC_209 4077-0173 175.592 µM -0.0910581620516015 0.487117215719357 no 1636 0.463723188163086 2645 15993494 SGTC_1982 st072467 71.9 µM -0.0919155913074234 0.48744032606641 no 1637 0.463382551914837 2541 3163533 SGTC_2980 9014342 25.29 µM -0.0924912120622667 0.487657245418702 no 1638 0.463153886525836 2728 2996599 SGTC_302 1094-0063 18.9 µM -0.0948154096954957 0.488533142331629 no 1639 0.462230723424397 2569 5440289 SGTC_1881 5652484 16 µM -0.0949107867767116 0.488569087340207 no 1640 0.462192844295431 2582 2255129 SGTC_2536 dehydroabietamide 32.04 µM -0.0954029282671663 0.488754563452457 no 1641 0.461997395134269 2651 3983547 SGTC_1994 st072947 40.9 µM -0.095601137558678 0.488829264384447 no 1642 0.461918680849641 2700 5286565 YDL195W SEC31 SGTC_227 fluconazole 33.516 µM -0.0962785248959241 0.489084560431273 no 1643 0.461649683246506 2587 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2417 cerulenin 830 nM -0.0970477309359959 0.489374466840563 no 1644 0.46134424475283 2567 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3082 9117008 49.47 µM -0.0976737411305045 0.489610408253937 no 1645 0.461095683687698 2636 41448529 SGTC_2885 9057732 51.95 µM -0.098461886366605 0.489907463050783 no 1646 0.460782767565083 2682 6471414 SGTC_2368 9071271 200 µM -0.0987894229046469 0.490030914415529 no 1647 0.460652733355316 2600 27209959 SGTC_1801 st050089 28.441 µM -0.0989006792246759 0.490072848106321 no 1648 0.460608564804188 2566 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2036 5160441 105 µM -0.10077211976803 0.490778230039267 no 1649 0.45986567967678 2609 134534 YIL048W NEO1 SGTC_502 l-744,832 89.3 µM -0.102453643592971 0.491412053371686 no 1650 0.459198303105472 2612 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2427 5545055 42.75 µM -0.10250095145456 0.491429885629549 no 1651 0.459179528838445 2599 5372858 SGTC_2711 st079103 59.1 µM -0.103526231940439 0.491816359708417 no 1652 0.458772665633841 2684 54693780 SGTC_2623 humulene 100 µM -0.103801084639271 0.491919965306378 no 1653 0.458663602851607 2643 6187145 An anti-inflammatory. SGTC_676 falcarinol 140 µM -0.104539714404578 0.492198394136817 no 1654 0.458370526690876 2620 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3022 9087993 49.47 µM -0.106380336772168 0.492892238815009 no 1655 0.457640296762175 2589 17173644 SGTC_1772 st048439 82.2 µM -0.106837825026673 0.493064697918141 no 1656 0.457458819581176 2657 2927068 YDL195W SEC31 SGTC_2743 auranofin 4.32 µM -0.107208972968841 0.493204610313724 no 1657 0.457311598530081 2637 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2618 avocadyne 43.43 µM -0.107301551932853 0.493239510125261 no 1658 0.457274876694021 2634 3015189 SGTC_1773 st048542 73.5835 µM -0.108026252984664 0.493512704948551 no 1659 0.456987433597728 2591 3237138 SGTC_806 3966-4455 5.86 µM -0.111483755456385 0.49481613968766 no 1660 0.45561637328188 2632 714982 SGTC_2616 abietic acid 100 µM -0.11383274045446 0.495701709769164 no 1661 0.454685192072806 2626 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1004 4084-0029 199 µM -0.114279470551207 0.495870130066769 no 1662 0.454508127999557 2687 716894 YLR208W SEC13 SGTC_3228 9131799 49.47 µM -0.116069098235512 0.496544839006279 no 1663 0.45379888964312 2652 17015818 SGTC_1785 bathophenanthroline 24 µM -0.116377633488309 0.496661161177027 no 1664 0.453676630411969 2627 72812 An iron chelator. SGTC_868 0527-0199 213 µM -0.11728107093084 0.497001771515474 no 1665 0.453318662356072 2674 2849450 SGTC_3086 9117350 49.47 µM -0.117565737045012 0.497109095649553 no 1666 0.453205877249114 2613 2679265 SGTC_2062 5245942 200 µM -0.120836613030116 0.498342286515734 no 1667 0.451910224784854 2595 1376160 SGTC_2413 inermin 26.06 µM -0.122386846046764 0.498926764087841 no 1668 0.451296327765169 2899 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_401 neomycin 50 µM -0.122922265779593 0.499128631646102 no 1669 0.451084326896612 2659 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_330 1488-0319 80.1 µM -0.125233418674142 0.5 no 1670 0.450169380610584 2696 6846614 SGTC_2824 7998404 51.95 µM -0.12585672026995 0.499764997942264 no 1671 0.449922671199006 2625 837851 SGTC_1065 prochlorperazine maleate 2.48 µM -0.126581611719604 0.499491693788949 no 1672 0.449635775788693 2639 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1336 1486-0901 104 µM -0.12720990484429 0.499254810067943 no 1673 0.449387133070217 2715 5006114 SGTC_2809 7964133 12.99 µM -0.127878040183585 0.499002905030687 no 1674 0.449122744871498 2675 1253665 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.128641939234526 0.498714894985132 no 1675 0.448820489645833 2612 1241132 A phosphatase inhibitor. SGTC_2526 patulin 37.61 µM -0.129239403084047 0.498489635849738 no 1676 0.4485841092432 2751 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2941 9056145 11.23 µM -0.1294644177344 0.498404799698795 no 1677 0.448495089247158 2605 2119517 SGTC_3347 9188721 44.724 µM -0.130571144002362 0.497987537338731 no 1678 0.448057285504719 2727 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_233 rapamycin 362 pM -0.131097304009185 0.497789163134549 no 1679 0.447849166923279 2676 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1242 0402-0103 60.1 µM -0.131237720489296 0.497736223041082 no 1680 0.447793628678849 2651 432868 SGTC_728 3030-5151 22.5 µM -0.131759313257514 0.497539571481193 no 1681 0.447587334609577 2637 3125388 SGTC_1284 0929-0043 16 µM -0.132164767632669 0.497386706974515 no 1682 0.447426983984842 2711 1239883 SGTC_2309 7664088 163.95 µM -0.132699153301358 0.497185233350092 no 1683 0.447215656255667 2675 704922 SGTC_3249 9135183 49.47 µM -0.132956845053044 0.497088078881275 no 1684 0.447113755033381 2802 4902779 SGTC_1981 st071826 47 µM -0.134347936621373 0.496563615232987 no 1685 0.446563724426414 2736 11838600 SGTC_3003 9075612 71.4286 µM -0.134739270400036 0.496416077205051 no 1686 0.446409011498828 2742 6501993 SGTC_2810 7959871 45.46 µM -0.135536040527498 0.496115685829685 no 1687 0.446094035461865 2751 2974535 SGTC_282 k297-0036 65.7 µM -0.137057152040209 0.495542215795346 no 1688 0.4454928102481 2782 5061378 SGTC_2027 5150920 200 µM -0.138932124283878 0.494835350509958 no 1689 0.44475189281117 2734 786715 SGTC_105 0111-0055 734.78 µM -0.139207707681684 0.494731456772471 no 1690 0.444643008980516 2733 5179370 SGTC_1141 3253-0389 52.6 µM -0.140370062388812 0.494293258139352 no 1691 0.444183805193505 2623 5402031 SGTC_2838 9002687 71.43 µM -0.141067478516691 0.494030340985482 no 1692 0.443908317537872 2629 6457060 SGTC_24 0417-1663 219 µM -0.142158830490246 0.493618920193961 no 1693 0.443477274981141 2722 4329390 SGTC_150 3970-0969 77.2 µM -0.142982021049642 0.493308596077994 no 1694 0.44315219020686 2784 6615640 SGTC_1499 4480-0877 67.3 µM -0.143695417785104 0.493039665004822 no 1695 0.442870494862255 2662 2861909 SGTC_1167 k781-0610 148 µM -0.144507845604366 0.492733405779082 no 1696 0.442549730791072 2718 4525169 SGTC_2463 5473429 200 µM -0.145796361381087 0.492247685522074 no 1697 0.44204107420425 2734 5399405 SGTC_2630 antimycin a 100 µM -0.145853562936997 0.49222612302478 no 1698 0.442018495433756 2618 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1581 himbacine 57.9 µM -0.147153501013424 0.49173610918724 no 1699 0.441505430884506 2659 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2295 7971645 200 µM -0.148194042009911 0.491343884464831 no 1700 0.441094816844827 2752 2978226 YKL099C UTP11 SGTC_188 3229-0966 278.469 µM -0.148449087283201 0.491247748177941 no 1701 0.440994181564768 2694 5722370 SGTC_354 2783-3500 4.88 µM -0.148620330330966 0.491183200429673 no 1702 0.44092661494538 2701 6740761 SGTC_56 0957-0365 83.25 µM -0.149357673955839 0.490905271392374 no 1703 0.440635704167503 2648 6752360 SGTC_2480 5767542 37.17 µM -0.149889746040045 0.490704718677824 no 1704 0.440425800897669 2711 2867358 SGTC_973 1325-0077 65.9 µM -0.151307031699956 0.490170516037117 no 1705 0.439866761325382 2753 2835149 SGTC_648 0375-0473 33.3 µM -0.151745211663196 0.490005360976114 no 1706 0.439693948153925 2693 1713139 SGTC_157 1348-1695 65.819 µM -0.15239860856951 0.489759091368692 no 1707 0.439436277230317 2679 5380510 SGTC_229 benomyl 22.8748 µM -0.152547091664458 0.489703127651027 no 1708 0.439377725619944 2740 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2555 cholic acid 100 µM -0.15281340450101 0.489602754063814 no 1709 0.439272713315356 2843 6708657 Influences liver metabolism. SGTC_3267 9137951 49.47 µM -0.153103841642743 0.489493288751549 no 1710 0.439158193202411 2641 16643986 SGTC_3272 9137413 49.47 µM -0.153507903589322 0.489340999743171 no 1711 0.438998879008583 2671 17614870 SGTC_989 1501-0895 10.3 µM -0.153646734182401 0.489288675516514 no 1712 0.43894414293872 2688 2830112 SGTC_1470 k295-0292 231 µM -0.154330315608008 0.489031041424316 no 1713 0.438674647626908 2782 5045612 SGTC_2441 5730946 39.09 µM -0.154670564324925 0.488902807238279 no 1714 0.438540518477193 2802 1774275 SGTC_2181 6316240 54.2555 µM -0.155885606252771 0.488444887229481 no 1715 0.438061595575061 2764 12779990 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.157962513531214 0.487662186550445 no 1716 0.437243168831451 2698 641818 YHR062C RPP1 SGTC_517 1365-0151 113 µM -0.158682020799657 0.487391044870574 no 1717 0.43695970200445 2848 768657 SGTC_1862 st057513 3.81 µM -0.158957352872805 0.48728728928721 no 1718 0.436851237006093 2705 5393163 SGTC_3303 9125618 40.5795 µM -0.159859159971747 0.486947460180009 no 1719 0.436496010164579 2784 22695467 SGTC_1318 1280-3875 124 µM -0.161131081211559 0.486468176661592 no 1720 0.435995080408988 2760 373245 SGTC_101 0490-5701 117.494 µM -0.162073700609401 0.486112992757301 no 1721 0.435623908115505 2669 4661669 SGTC_2863 9028737 58.44 µM -0.163149508463365 0.48570763622546 no 1722 0.435200359923044 2807 6460917 SGTC_443 clozapine 122 µM -0.163173022473693 0.485698776481723 no 1723 0.435191103227844 2659 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM -0.163712375153264 0.485495558031075 no 1724 0.434978787515502 2664 669075 SGTC_692 k241-0027 77.8 µM -0.164183667088742 0.485317986734501 no 1725 0.434793279200931 2840 3600480 SGTC_1422 4031-0024 15.5 µM -0.166899206030865 0.484294895753333 no 1726 0.433724678941388 2688 782427 SGTC_2528 xanthyletin 44.79 µM -0.167087550461533 0.484223939935187 no 1727 0.433650580801015 2736 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.167445352080185 0.484089145149999 no 1728 0.43350982153138 2699 688664 SGTC_3067 9117431 49.47 µM -0.168368532936543 0.483741363193666 no 1729 0.433146680882764 2751 17150885 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.169289562402599 0.483394404037887 no 1730 0.432784442743766 2677 5355888 SGTC_1860 st056228 74.6 µM -0.169389929563642 0.483356595681795 no 1731 0.43274497204615 2822 688679 SGTC_3189 9110682 49.47 µM -0.170415031833449 0.48297044781141 no 1732 0.432341875678187 2794 17122418 SGTC_1736 st036774 51 µM -0.170521036114888 0.482930517746987 no 1733 0.432300196100078 2991 1272247 SGTC_3312 9133330 71.43 µM -0.170631748921585 0.482888814241553 no 1734 0.432256665992156 2862 17617324 SGTC_192 3455-0609 60.9 µM -0.170900410449847 0.4827876150979 no 1735 0.432151036959392 2830 3769639 SGTC_3020 9089140 49.47 µM -0.171522738115015 0.482553201633947 no 1736 0.431906376468888 2778 17217859 SGTC_351 caspofungin 25 nM -0.172442001439794 0.482206951851547 no 1737 0.431545027169007 2746 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2299 7976368 114.88 µM -0.172602308660366 0.482146571890538 no 1738 0.431482018544026 2835 2979718 SGTC_2674 ligustilide 100 µM -0.173793326197468 0.48169798622099 no 1739 0.431013944750755 2798 5319022 A signalling regulator. SGTC_3187 9109394 49.47 µM -0.174915953799628 0.481275180187961 no 1740 0.430572837107116 2752 17098090 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.176428233569693 0.480705656035318 no 1741 0.429978762682827 2791 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2216 7189485 200 µM -0.176542738508272 0.480662535095607 no 1742 0.429933787724348 2821 731273 SGTC_738 1315-0003 72.4 µM -0.177568444657818 0.480276278823944 no 1743 0.429530954087939 2872 6251474 SGTC_2666 tannic acid 100 µM -0.177810871187157 0.480184989514626 no 1744 0.429435754715492 2803 16134267 A thiamine antagonist. SGTC_44 0929-0055 61.211 µM -0.17781484102689 0.480183494621164 no 1745 0.429434195818546 2730 1379590 SGTC_307 1501-1223 22.3 µM -0.178777873949941 0.47982086065355 no 1746 0.429056059699893 2794 2830329 SGTC_2165 5727197 32.143 µM -0.180381318631993 0.479217114231065 no 1747 0.428426609671256 3135 1361712 SGTC_3255 9139072 49.47 µM -0.181280517288248 0.478878558956559 no 1748 0.428073698809589 2789 17646060 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.181291769529545 0.478874322496392 no 1749 0.428069282976687 2768 676296 Flavone; oxidizing agent. SGTC_985 1493-0307 8.71 µM -0.183341130033409 0.478102780131846 no 1750 0.427265182101613 2823 3278274 SGTC_763 3453-1109 128 µM -0.183515392650234 0.478037177561344 no 1751 0.427196821137917 2736 1560353 SGTC_3305 9127027 53.8275 µM -0.1839922506337 0.477857663566989 no 1752 0.427009767119789 2768 41905295 SGTC_1161 k007-0610 110 µM -0.18598316282268 0.477108230254139 no 1753 0.426228982543962 2812 5843850 SGTC_432 NS 1619 61.3 µM -0.186983346442364 0.476731764413386 no 1754 0.425836845137035 2910 4552 A K+/calcium channel activator. SGTC_1649 st011737 51.3 µM -0.187000932071283 0.476725145425007 no 1755 0.425829951074999 2776 1761035 SGTC_2610 ononetin 44.17 µM -0.189897600127965 0.475634968487111 no 1756 0.424694686536744 2817 259632 SGTC_869 0564-0080 44.1 µM -0.190116943966807 0.475552424553698 no 1757 0.424608746429855 2775 6843321 SGTC_2284 7945075 39.21 µM -0.190414374604514 0.475440496509054 no 1758 0.424492217216506 2872 1245402 SGTC_420 mitomycin C 81.9 mM -0.190725919664485 0.475323259053342 no 1759 0.424370165244389 2749 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1267 0828-0272 9.49 µM -0.190857709326567 0.475273665955903 no 1760 0.424318537051844 2875 745334 SGTC_694 1315-0438 43.2 µM -0.190895046568107 0.475259615838047 no 1761 0.424303910538969 2791 6793154 SGTC_1679 SEC14.276 6.7 µM -0.192435626336986 0.474679918000136 no 1762 0.423700494040538 2902 1005053 YMR079W SEC14 SGTC_2647 atorvastatin 60.16 µM -0.194612633557398 0.473860833413877 no 1763 0.422848106008179 2825 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2995 9067767 71.4286 µM -0.194709161848353 0.473824517814698 no 1764 0.42281031953562 2835 11673567 SGTC_455 paf C-16 10 µM -0.195040014718484 0.473700046940914 no 1765 0.42268081094895 2737 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2333 9017922 200 µM -0.195187325557164 0.473644627637096 no 1766 0.422623150487398 2890 3163164 SGTC_595 3909-8003 73.7 µM -0.195310436160494 0.47359831301178 no 1767 0.422574963762367 2852 699517 SGTC_369 0957-0393 4.5 µM -0.195634659708363 0.473476340725754 no 1768 0.422448064959053 2818 6997992 SGTC_3277 9138724 49.47 µM -0.19628618478238 0.473231245754662 no 1769 0.422193087004507 2825 15943418 SGTC_3279 9140807 49.47 µM -0.197087785969827 0.472929708081482 no 1770 0.421879420677632 2725 45595718 SGTC_2100 5377183 190 µM -0.198411518928937 0.472431794560665 no 1771 0.421361552898127 2853 2844202 SGTC_3073 9114972 49.47 µM -0.199428023337581 0.472049472255314 no 1772 0.420963970637399 2862 41905075 SGTC_3147 9097027 49.47 µM -0.199618371549254 0.471977882336693 no 1773 0.420889529270053 2783 25236841 SGTC_1446 4239-0190 62 µM -0.199653462224298 0.471964684840646 no 1774 0.420875806319638 2772 1340085 SGTC_2929 9013348 24.6 µM -0.200944024212487 0.471479329910067 no 1775 0.420371171691307 2868 2995952 SGTC_1875 nocodazole 6 µM -0.201047155016713 0.471440546265052 no 1776 0.420330851193128 2774 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3168 9103419 49.47 µM -0.201234659440738 0.471370033545876 no 1777 0.420257545734703 2754 16649256 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.201479456924067 0.471277976609312 no 1778 0.420161845533391 2914 23847180 SGTC_1642 st009582 77.7 µM -0.202431235168108 0.470920071750667 no 1779 0.419789805851469 2882 6739311 SGTC_1457 k015-0032 57.3 µM -0.203343041661145 0.470577219816342 no 1780 0.41943345790652 2747 4302660 SGTC_1108 betulinic acid 729.144 nM -0.203893543669227 0.47037023393995 no 1781 0.419218345254447 2801 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_793 0488-0545 106 µM -0.204125851800894 0.470282889695841 no 1782 0.419127576407591 2755 292548 SGTC_2712 st079126 47.7 µM -0.204795004639745 0.470031306641765 no 1783 0.418866145009714 2750 3152970 SGTC_1765 st044815 90.4 µM -0.204967296306254 0.469966531648745 no 1784 0.418798838154036 2849 645695 SGTC_265 mycophenolic acid 32.932 µM -0.205111786056942 0.469912209711858 no 1785 0.418742394129281 3014 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1704 st028805 70.8 µM -0.205153824817087 0.469896405049754 no 1786 0.418725972262515 2815 2876101 SGTC_2383 9036125 200 µM -0.206680106294981 0.469322624938061 no 1787 0.418129847412484 2766 79580 SGTC_1979 st071809 45.3 µM -0.207156837701355 0.46914341870296 no 1788 0.417943687309233 2913 4976333 SGTC_97 0535-0701 19.132 µM -0.207365434626704 0.469065007813917 no 1789 0.417862237525586 2784 2832013 YGL099W LSG1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.207397774356409 0.469052851524651 no 1790 0.417849610310678 2908 61125 An anti-inflammatory. SGTC_3165 9101544 49.47 µM -0.20752581024433 0.469004723969423 no 1791 0.417799618866841 2880 5002184 SGTC_2993 9054257 71.4286 µM -0.210241650865836 0.46798397135915 no 1792 0.416739536623599 2755 6470217 YGL055W OLE1 SGTC_701 4424-0219 185 µM -0.210517187076164 0.467880422324969 no 1793 0.416632019430701 2919 2911779 SGTC_2724 maprotiline 69.64 µM -0.210889125721849 0.467740647819807 no 1794 0.416486894863038 2818 4011 A tricyclic antidepressant. SGTC_1230 0170-0365 3.77 µM -0.210978071897813 0.467707222444578 no 1795 0.416452191159993 2880 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.210984586276826 0.467704774393665 no 1796 0.416449649501556 3018 6710655 SGTC_2435 5706476 10.6 µM -0.212874599735509 0.466994574590075 no 1797 0.415712387388606 2926 5725375 SGTC_1105 epirubicin 18.1 µM -0.214048488926486 0.466553521552739 no 1798 0.415254622317837 2773 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2376 9072922 81.32 µM -0.214081626380574 0.466541071759183 no 1799 0.415241701836815 2915 17087968 SGTC_3077 9117319 49.47 µM -0.214569248936136 0.466357874990854 no 1800 0.41505158564605 2758 17154678 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.216191571133904 0.465748430128217 no 1801 0.41441921172974 3001 165506 SGTC_971 1315-0384 26.7 µM -0.217052505965238 0.465425042125926 no 1802 0.414083713159231 2819 6769120 SGTC_1026 k007-1105 30.6 µM -0.217301696894664 0.465331444220608 no 1803 0.413986617380094 2800 7066794 SGTC_329 k048-0121 21.3 µM -0.217437287750449 0.465280516125367 no 1804 0.413933787409425 2872 6832902 SGTC_1451 4152-0210 104 µM -0.217453014604391 0.46527460913612 no 1805 0.413927659890265 2952 659563 SGTC_1579 chlormadinone acetate 49.4 µM -0.217489452650108 0.465260923075157 no 1806 0.413913462927686 2957 45114258 A steroidal progestin. SGTC_2465 5809242 33.21 µM -0.217501385158171 0.465256441256657 no 1807 0.413908813817778 2773 2731748 SGTC_1445 4239-0156 97.7 µM -0.217702417776304 0.465180934599511 no 1808 0.413830489874473 2971 4008346 SGTC_1180 1193-0155 285 µM -0.218154116364235 0.465011283870173 no 1809 0.413654516938481 2931 2921347 SGTC_2508 celastrol 40.54 µM -0.22046337737953 0.464144062573988 no 1810 0.412755145661927 2797 122724 Celastrol is a natural product and antioxidant. SGTC_2614 arthonioic acid 13.39 µM -0.220655321001058 0.46407198755911 no 1811 0.41268041130316 2761 6710684 SGTC_465 cgp-37157 41 µM -0.221053286764836 0.463922554790433 no 1812 0.412525471119639 2888 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_189 3970-0742 2.116 µM -0.221852175863745 0.463622594094269 no 1813 0.412214480446546 2813 2891807 SGTC_3004 9076122 71.4286 µM -0.22206465598018 0.463542817178935 no 1814 0.412131775690494 2944 44782551 SGTC_2461 5755302 26.15 µM -0.22297646945777 0.463200488104101 no 1815 0.411776910070557 2948 2788904 SGTC_3176 9106582 49.47 µM -0.224877392406649 0.462486898042793 no 1816 0.411037328561178 2848 17018027 SGTC_2389 9091542 195.52 µM -0.22667755429215 0.461811244062269 no 1817 0.410337240953423 2865 3626624 YOL127W RPL25 SGTC_1493 4348-0038 111 µM -0.227689403678848 0.461431515322658 no 1818 0.409943855365282 2842 800424 SGTC_2884 9058502 51.95 µM -0.229009809386904 0.460936043914977 no 1819 0.409430645965045 2917 6471554 SGTC_3064 1327-0027 10 µM -0.231209630787414 0.460110714021007 no 1820 0.408575974205156 2813 16000455 YPR107C YTH1 SGTC_1023 4482-3888 16 µM -0.231213355541846 0.460109316710838 no 1821 0.408574527435837 3020 3303168 SGTC_574 1315-0397 40 µM -0.231657463653052 0.459942716839447 no 1822 0.408402035875255 2806 6794277 SGTC_785 1270-0111 65.3 µM -0.231720208451363 0.459919179724138 no 1823 0.408377667229708 2788 6741994 SGTC_2869 9037858 32.47 µM -0.234035695008252 0.459050682751539 no 1824 0.407478633722417 2768 27187042 SGTC_2121 5257820 149.641 µM -0.234293232139798 0.458954097248679 no 1825 0.407378669846883 2962 791256 SGTC_946 3434-1334 87.4 µM -0.235793468514128 0.458391504071068 no 1826 0.40679646832374 2973 4047976 SGTC_2259 7964009 200 µM -0.235984630021382 0.458319823890438 no 1827 0.406722298431562 2972 313134 SGTC_967 1306-0166 352 µM -0.235999171879029 0.458314371158879 no 1828 0.406716656386479 2968 4437607 SGTC_3138 9097216 49.47 µM -0.236318735959462 0.458194546830709 no 1829 0.406592674713582 2758 25237486 SGTC_3230 9131665 49.47 µM -0.239743932474679 0.456910469705931 no 1830 0.40526438737854 2821 15943720 SGTC_202 3594-0513 34.79 µM -0.240230051758667 0.456728263845879 no 1831 0.405075958880645 2804 708429 SGTC_2511 berberine 10.47 µM -0.24110377585835 0.456400799935885 no 1832 0.40473734319097 2845 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_162 k030-0015 37.8 µM -0.241581131238507 0.456221903939153 no 1833 0.404552372087915 2908 1809920 YMR134W ERG29 SGTC_1086 cerivastatin 2.18 µM -0.242010099667139 0.456061149238186 no 1834 0.40438616870727 2817 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1036 k216-0215 33.5 µM -0.243076136125055 0.455661686303122 no 1835 0.403973208744828 2824 622330 SGTC_859 0439-0102 54.6 µM -0.243399204590414 0.45554063559952 no 1836 0.403848079964651 2937 610143 SGTC_1530 rhein 70.4 µM -0.244394270130056 0.455167819919369 no 1837 0.403462739517167 2827 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1877 wortmannin 25 µM -0.244998995913755 0.454941269934544 no 1838 0.403228604408415 2977 312145 A covalent inhibitor of PI 3-kinase. SGTC_2091 4-phenylthiadiazole 200 µM -0.245429893745451 0.45477985050203 no 1839 0.403061792411695 2848 270010 SGTC_1343 1487-0095 224 µM -0.247166290994317 0.454129451462829 no 1840 0.402389765979973 2918 4560101 YGL055W OLE1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.248748893027835 0.453536766286472 no 1841 0.401777513030513 2834 442882 SGTC_1715 st032160 10.2275 µM -0.249420261664744 0.45328536960951 no 1842 0.401517856880362 2963 5289825 SGTC_1301 naphtanilide LB 4.81 µM -0.250078574597809 0.453038879870073 no 1843 0.401263292323752 2977 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1848 st056003 16.4 µM -0.25180527856595 0.452392442533188 no 1844 0.400595788529418 2857 146492 SGTC_736 0958-0254 92.6 µM -0.252118536722418 0.452275179522147 no 1845 0.400474721216847 2969 6812352 SGTC_1135 dihydrocapsaicin 536.708 nM -0.253971116213891 0.45158178246791 no 1846 0.399758936277734 2802 107982 A Capsaicinoid. SGTC_1378 2093-0007 380 nM -0.254611215733376 0.451342235543894 no 1847 0.399511697862302 2967 3618014 SGTC_1361 1608-0041 5.61 µM -0.256435528445618 0.450659613425889 no 1848 0.398807278517262 2876 X1361 SGTC_2738 aclarubicin 5.55 µM -0.256909032546381 0.450482461227775 no 1849 0.398624498799189 2933 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1821 st053465 65.6 µM -0.258695917641753 0.44981402264412 no 1850 0.397934934810566 2936 675086 SGTC_291 SEC14.278 35.5 µM -0.261201810085101 0.448876857785584 no 1851 0.396968441157405 2973 1068044 SGTC_514 4466-0038 2.65 nM -0.262473931050623 0.448401213097726 no 1852 0.396478040509 2911 5722064 SGTC_345 1362-0200 395 µM -0.262982585979099 0.448211048273828 no 1853 0.396282000604212 2887 1419823 SGTC_2719 novobiocin 32.65 µM -0.263496568943039 0.448018903608119 no 1854 0.396083933865164 2984 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_173 1273-0061 2.693 µM -0.263799144162924 0.447905796192364 no 1855 0.395967347040157 2970 2847414 YPL266W DIM1 SGTC_3335 9143315 29.6265 µM -0.263877584576096 0.447876474612891 no 1856 0.395937124276801 2907 4899691 SGTC_1435 4092-0789 56.7 µM -0.26514041272958 0.447404459857082 no 1857 0.395450648090824 2976 2248285 SGTC_3074 9116018 49.47 µM -0.265643592296113 0.447216404164915 no 1858 0.395256854796664 2844 17027303 SGTC_2649 anisomycin 9.56 µM -0.265875026582758 0.44712991311002 no 1859 0.395167729479828 2934 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_929 2805-0021 398 µM -0.266244018174766 0.446992019677708 no 1860 0.395025642204371 2950 3098024 SGTC_1689 st020265 53.493 µM -0.268353189004422 0.446203938751709 no 1861 0.39421373406862 3013 5758320 YPR016C TIF6 SGTC_1870 st057514 26.5 µM -0.268484389066329 0.44615492350442 no 1862 0.394163244816146 2834 5393161 SGTC_1677 st019204 53.9 µM -0.269155236496181 0.445904313382814 no 1863 0.39390511280185 2983 3945625 SGTC_292 k038-0015 474 µM -0.271341551205779 0.44508771692275 no 1864 0.393064175748889 2999 46368540 SGTC_937 3122-0005 46.7 µM -0.272599363486522 0.444618024822265 no 1865 0.392580600640153 3048 759535 SGTC_682 0kpi-0099 17 µM -0.27310907124725 0.444427711917052 no 1866 0.392384686933891 2988 1714895 YML126C ERG13 SGTC_1895 st058434 18.3 µM -0.273257637818349 0.444372243058507 no 1867 0.392327588308573 3060 5393175 SGTC_1215 3852-0577 11.2 µM -0.27362750163002 0.444234155332099 no 1868 0.392185448533727 3045 2884876 SGTC_2069 5228469 200 µM -0.275269842293156 0.443621073555804 no 1869 0.391554466074987 3009 2835210 SGTC_2403 6032726 181.2 µM -0.277047291048108 0.442957708320818 no 1870 0.390871896884693 2970 2881040 SGTC_3309 9129340 25.759 µM -0.277146326412109 0.442920751817503 no 1871 0.390833875561303 2926 17158987 SGTC_2440 5628896 157.78 µM -0.278035961517953 0.442588793691744 no 1872 0.390492376681091 2894 5522048 SGTC_285 1486-1325 46 µM -0.278065305634688 0.442577844923833 no 1873 0.390481113968896 3016 22310230 SGTC_2539 epi(13)torulosol 80 µM -0.27832722857565 0.442480119152086 no 1874 0.390380588087098 3007 6708597 SGTC_315 k915-0449 187 µM -0.278338437302602 0.442475937154723 no 1875 0.390376286347275 2934 20970215 YNL149C PGA2 SGTC_347 4534-1311 26.2 µM -0.279419572543624 0.442072593733729 no 1876 0.389961426150045 2855 2862016 SGTC_2292 7671323 168.05 µM -0.279787531277671 0.441935331582026 no 1877 0.389820259206806 3055 937504 SGTC_2664 lyso-paf C-16 73.48 µM -0.279887029687564 0.4418982162096 no 1878 0.389782089252192 2903 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1628 st004252 77.7 µM -0.280592615049061 0.441635030038954 no 1879 0.389511440455576 3063 692968 SGTC_2686 alizarin 95.37 µM -0.281894711350178 0.441149410628727 no 1880 0.389012122445893 2956 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.283226370398367 0.440652857242739 no 1881 0.388501657475162 2939 6708561 SGTC_2166 5933061 31.504 µM -0.285267390428065 0.439891976363945 no 1882 0.387719646997371 3389 2877375 SGTC_2225 6654152 15.4 µM -0.286322942740195 0.4394985592485 no 1883 0.387315393797877 2959 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_293 4049-0273 38.5 µM -0.288431321473112 0.438712920217188 no 1884 0.38650829745354 2956 1380311 SGTC_613 3914-0030 117 µM -0.28845578174568 0.438703807067692 no 1885 0.386498936830062 2849 1145395 SGTC_2247 cerulenin 830 nM -0.289844450839231 0.438186484869853 no 1886 0.385967619963348 3140 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1614 st002383 48.6 µM -0.289952003965786 0.438146422398234 no 1887 0.385926478111306 2976 1947235 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.290076729552976 0.438099964149391 no 1888 0.385878768955679 3331 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3043 9092303 49.47 µM -0.290131041584967 0.438079734069075 no 1889 0.385857994438074 2950 25236084 SGTC_2701 st077767 14.721 µM -0.292744329341264 0.437106531968969 no 1890 0.384858791770529 2945 5721188 SGTC_1887 st057648 70.8 µM -0.294495027198207 0.4364547753233 no 1891 0.38418983137746 3060 688672 SGTC_313 3474-0040 5.03 µM -0.294523137067639 0.436444311873401 no 1892 0.384179093103047 2912 1043375 YIL048W NEO1 SGTC_261 5-fluorouridine 15.376 µM -0.294695594878856 0.436380118181486 no 1893 0.384113214298429 3131 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1387 3342-1166 1.8 µM -0.294809055122339 0.436337885972423 no 1894 0.384069874363372 2987 3418228 SGTC_2419 paclitaxel 166.5 µM -0.294875255819105 0.436313245062571 no 1895 0.384044587462581 2831 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_476 mead acid 10 µM -0.295907145191835 0.435929192097519 no 1896 0.383650497116037 2914 5312531 An omega 9 fatty acid. SGTC_103 0844-0104 51.839 µM -0.297562305215708 0.435313293921063 no 1897 0.383018624012512 3040 5375804 SGTC_399 oxolinic acid 75 µM -0.297672978513301 0.435272117088488 no 1898 0.382976384507011 2926 4628 A DNA gyrase inhibitor. SGTC_481 bay k-8644 50 µM -0.297732136573252 0.435250107175271 no 1899 0.382953806847406 2932 2303 A calcium channel antagonist. SGTC_2817 7995342 71.43 µM -0.29778316114236 0.435231123510038 no 1900 0.382934333652068 2883 18879975 SGTC_3331 9141060 1.957 µM -0.299131805088035 0.434729415458311 no 1901 0.382419739855424 2933 4906567 YPR165W RHO1 SGTC_1630 st005209 31.3 µM -0.300047992405158 0.434388645174125 no 1902 0.382070274224258 2967 3367314 SGTC_1431 4049-0260 9.09 µM -0.300395547748511 0.434259386823416 no 1903 0.381937729673589 2912 3854841 SGTC_515 4092-1064 102 µM -0.300456225494548 0.434236821050194 no 1904 0.381914590879223 3172 717353 SGTC_2757 clomiphene 4.22 µM -0.301031075077107 0.434023047789734 no 1905 0.381695399222117 3164 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_931 2812-0076 566 µM -0.301945047173354 0.43368320246206 no 1906 0.381346977374525 2905 3450959 SGTC_1891 st059073 26.2 µM -0.303207143510113 0.433213993558232 no 1907 0.380866002690609 3128 688754 SGTC_3097 9117246 49.47 µM -0.305408679521688 0.432395755325565 no 1908 0.380027456041388 2926 16423892 SGTC_741 4582-0002 126 µM -0.305532015445564 0.432349923977146 no 1909 0.379980495057788 2934 2912688 SGTC_2801 7907800 81.82 µM -0.306262266540245 0.432078583003762 no 1910 0.379702483314029 3039 6620925 SGTC_124 0136-0217 7.121 µM -0.307140873275725 0.431752159675829 no 1911 0.379368073941463 3097 3976905 SGTC_2518 prenyletin 46.28 µM -0.307947447158273 0.431452539282904 no 1912 0.379061160659274 3046 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1159 4092-0538 61.2 µM -0.30841145863368 0.431280189421753 no 1913 0.378884631961905 2961 717301 SGTC_912 3474-0017 2.18 µM -0.308809289434978 0.431132431761135 no 1914 0.378733301176625 3118 3360550 SGTC_406 estrone 100 µM -0.309068715035186 0.431036084130913 no 1915 0.37863462833302 3120 5870 A steroid. SGTC_76 0433-0009 400.328 µM -0.309832361936209 0.430752498454875 no 1916 0.378344220243848 3064 2841569 SGTC_376 3970-0862 59.1 µM -0.310725112636581 0.430421014447711 no 1917 0.378004802252605 3065 3135186 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.310823502594414 0.430384484626309 no 1918 0.377967400787574 3024 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1285 0929-0069 65.5 µM -0.311259784350867 0.430222510901106 no 1919 0.377801568614283 2975 1206237 SGTC_792 4534-1957 155 µM -0.311375921323492 0.430179395930019 no 1920 0.377757428351397 2983 1717904 SGTC_1966 st070145 16.1 µM -0.311572853968441 0.43010628808069 no 1921 0.377682583667515 2891 3748532 SGTC_490 phenamil 164 µM -0.312787792602151 0.429655316141432 no 1922 0.377220945230221 3027 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2272 7805186 180 µM -0.312969269065809 0.429587961925875 no 1923 0.37715200492789 3091 2956062 YPR165W RHO1 SGTC_2300 7976697 71.57 µM -0.313266324572329 0.429477715465479 no 1924 0.377039166258042 2942 2236109 SGTC_1996 st072960 66.8 µM -0.315881199304948 0.428507493036481 no 1925 0.376046341316305 3086 1719405 SGTC_554 4483-2211 187 µM -0.316233436333049 0.428376831984558 no 1926 0.375912665221301 3054 747107 SGTC_1898 st060199 18.6 µM -0.316723281303769 0.428195138817854 no 1927 0.375726790828744 2943 688866 SGTC_474 dl-dihydrosphingosine 5 µM -0.318148825282058 0.427666463164478 no 1928 0.375186024464934 3109 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2543 pimpinellin 60.67 µM -0.320287796532583 0.426873450527384 no 1929 0.374375086629886 2979 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2251 lansoprazole 556 µM -0.320292585535047 0.426871675359566 no 1930 0.37437327162039 2950 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1322 1348-1070 12 µM -0.321183302957261 0.426541533666709 no 1931 0.374035742343436 3096 6758089 SGTC_3130 9127414 49.47 µM -0.321423122444712 0.42645265408955 no 1932 0.37394488141377 3006 1494646 SGTC_685 1278-0033 54.9 µM -0.322410232296684 0.426086860363721 no 1933 0.373570966754011 3121 3590572 SGTC_3048 9093155 49.47 µM -0.322463049371894 0.426067289706631 no 1934 0.373550963133043 3077 25236002 SGTC_3092 9117248 49.47 µM -0.323484672013505 0.425688777052873 no 1935 0.373164107014239 3017 17141857 SGTC_987 1497-1013 404 µM -0.323599329567762 0.425646300531493 no 1936 0.373120697803395 2975 1676435 SGTC_264 promethazine 12.5 mM -0.325382075389549 0.424985968299827 no 1937 0.372445959922042 3052 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2928 9011484 9.79 µM -0.326637933054731 0.424520922592846 no 1938 0.371970874718729 3106 2994751 SGTC_2803 7707263 71.43 µM -0.32665246769293 0.424515541011343 no 1939 0.371965377470938 2979 2199229 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.327087582842299 0.424354442204724 no 1940 0.371800821598883 3087 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2752 diclazuril 33.15 µM -0.327987422356922 0.42402132207444 no 1941 0.37146058629135 3105 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2052 5265182 7.135 µM -0.328773264101489 0.423730448251997 no 1942 0.371163536418044 3148 1239884 SGTC_1815 st051655 58.2 µM -0.329863258790819 0.423327063165133 no 1943 0.37075164314613 3079 5984156 SGTC_2066 5222451 176 µM -0.330026301320597 0.423266731306259 no 1944 0.370690044445755 2982 2281147 SGTC_2889 9059656 51.95 µM -0.330071409414994 0.423250039935044 no 1945 0.370673002851947 3068 3949838 SGTC_797 k781-0471 270 µM -0.331817334837709 0.422604100386315 no 1946 0.370013596945937 2988 23738129 SGTC_2450 5739737 12.93 µM -0.332448617044181 0.422370596206305 no 1947 0.369775266462914 3086 2262825 SGTC_1710 st031758 61.5 µM -0.332748683469255 0.422259614574677 no 1948 0.369661998722602 3153 5394341 SGTC_3051 9093778 49.47 µM -0.335077333211733 0.421398557909791 no 1949 0.368783375479066 3043 17217378 SGTC_1075 aripiprazole 15.2 µM -0.335651166254246 0.421186431220289 no 1950 0.368566967514327 2978 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3320 9137005 35.139 µM -0.336851250352228 0.420742874688512 no 1951 0.368114518133639 3041 4908713 SGTC_1360 1598-0022 39.8 µM -0.338073426285477 0.420291256310655 no 1952 0.367653927755335 3115 761525 SGTC_1231 0242-0792 125 µM -0.338212790885817 0.420239764964795 no 1953 0.367601418754039 2984 3707635 SGTC_2942 9052777 62.25 µM -0.339508684568246 0.419761033744691 no 1954 0.367113277927373 3030 6469503 SGTC_1934 st074720 32.6 µM -0.339665911464524 0.419702958782382 no 1955 0.367054067855484 2969 17250992 SGTC_457 grayanotoxin iii 135 µM -0.340347147265018 0.419451350658219 no 1956 0.366797557834468 3080 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2163 5671233 125 µM -0.34052740076886 0.419384781203713 no 1957 0.366729695788306 3230 701023 SGTC_2373 9071805 200 µM -0.341184010409511 0.419142308101657 no 1958 0.366482529873114 3165 10149009 SGTC_90 0870-0863 4.608 µM -0.344159962552302 0.418043733445206 no 1959 0.365362995196414 2969 1738164 SGTC_1313 1220-0047 237 µM -0.345116494663357 0.417690764317363 no 1960 0.365003396729737 3059 3528706 SGTC_1416 3966-0321 25.3 µM -0.345132901039033 0.417684710791715 no 1961 0.364997229955062 3060 582530 YLR208W SEC13 SGTC_426 0988-0037 14.6 µM -0.345366319556683 0.417598587547032 no 1962 0.364909497151399 3216 5383008 SGTC_3211 9128781 49.47 µM -0.345735536931916 0.417462367359696 no 1963 0.364770737362168 3106 17194361 SGTC_1962 st076595 64.5 µM -0.346067244315514 0.417339994669462 no 1964 0.364646089733942 3016 279619 SGTC_2190 6049624 200 µM -0.346070197151179 0.417338905352364 no 1965 0.364644980193806 3102 2265554 SGTC_2220 6782180 200 µM -0.346823180617093 0.417061146397622 no 1966 0.364362080594528 3085 833803 SGTC_3262 9137218 49.47 µM -0.347744058423654 0.416721511208147 no 1967 0.364016202691195 2927 17650664 SGTC_304 1310-0298 97 µM -0.34817019746094 0.416564364999732 no 1968 0.363856184092499 3077 1550234 SGTC_1018 4259-0013 28.1 µM -0.348350931241694 0.416497720288596 no 1969 0.363788324287944 3150 6801262 SGTC_3227 9130768 49.47 µM -0.350568231657052 0.415680297364935 no 1970 0.362956146593381 3030 17720899 SGTC_2722 naftopidil 47.16 µM -0.351302214990287 0.415409789576809 no 1971 0.362680816696636 3143 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2318 6029776 164 µM -0.352231691696322 0.415067290717292 no 1972 0.36233225571899 3213 818325 SGTC_42 0133-0086 60.653 µM -0.357794714323826 0.413018754300105 no 1973 0.360248473220171 2960 162923 Model of phenazepam hydroxylation. SGTC_3126 9127922 49.47 µM -0.358081858619539 0.412913079567043 no 1974 0.360141027432754 3253 45595682 SGTC_899 1083-0020 478 µM -0.358121983697784 0.412898313253555 no 1975 0.360126014012191 3206 767123 SGTC_2580 diallyl disulphide 81.36 µM -0.358597910579107 0.412723178190143 no 1976 0.359947955046301 3010 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2076 5212012 200 µM -0.358884850395394 0.412617596364729 no 1977 0.359840616666861 3040 604802 SGTC_1397 3532-0190 20.1 µM -0.359053555718162 0.412555522827951 no 1978 0.359777512578317 2969 5322280 SGTC_3023 9089636 49.47 µM -0.359579327543045 0.412362084065117 no 1979 0.359580872581472 3136 17249241 SGTC_2600 tangeritin 87.95 µM -0.359855275891529 0.412260567346821 no 1980 0.35947768207054 3007 68077 A bioactive flavone. SGTC_2840 9008771 71.43 µM -0.361688081202021 0.411586458636214 no 1981 0.358792567369076 3132 2992978 SGTC_1912 st060209 90.8 µM -0.363962045059346 0.410750453949214 no 1982 0.357943176008353 3096 688787 SGTC_8 0354-0001 70 µM -0.366143852257747 0.40994871082 no 1983 0.357128868336633 3079 4993152 SGTC_221 trifluoperazine 10.304 µM -0.367468741847711 0.409462040444917 no 1984 0.356634701898205 3083 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2708 st078559 56 µM -0.367889118299296 0.409307653096006 no 1985 0.356477957226638 3155 17250902 SGTC_2927 9011802 47.9 µM -0.369122707045462 0.408854686888659 no 1986 0.356018132223946 3148 43912568 SGTC_2013 4024628 200 µM -0.369128463643932 0.40885257338591 no 1987 0.356015986919715 3199 5230760 SGTC_2815 7968870 71.43 µM -0.369156238758211 0.408842375946174 no 1988 0.356005636067261 3030 2977326 YHR190W ERG9 SGTC_1047 2043-3044 82 µM -0.370624775476648 0.408303300963083 no 1989 0.355458513061823 3073 669592 SGTC_608 k048-0125 159 µM -0.371703231296751 0.40790752850178 no 1990 0.355056909447924 3169 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2754 granisetron 64.02 µM -0.372253775627061 0.407705525560381 no 1991 0.354851955577259 3181 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1442 4112-3290 3 µM -0.372957966835815 0.407447183051534 no 1992 0.354589864044614 3051 704353 SGTC_1500 4488-1866 171 µM -0.373461570877596 0.407262453461032 no 1993 0.354402470856476 3181 2900003 SGTC_2338 7999974 200 µM -0.374724160867705 0.406799407087462 no 1994 0.353932810817607 3092 315925 SGTC_3226 9131256 49.47 µM -0.375249621705579 0.406606736215146 no 1995 0.353737414569844 3109 17178073 SGTC_910 3454-3003 490 µM -0.375826288363569 0.406395315710005 no 1996 0.353523021423751 3203 820824 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.376820910969637 0.406030726189758 no 1997 0.353153349810274 3218 16725076 SGTC_922 1866-0035 480 µM -0.377014314119416 0.405959841655569 no 1998 0.353081483694032 3053 3156169 SGTC_1509 1326-1131 80 µM -0.378132855913038 0.405549943446547 no 1999 0.35266595084839 3177 768313 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.378296810386326 0.405489869764967 no 2000 0.352605057312673 3009 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1993 st073995 70.8 µM -0.380481557064252 0.404689581428747 no 2001 0.351793992162431 3077 3098394 SGTC_2125 5246583 200 µM -0.381774142688048 0.404216285492559 no 2002 0.351314449895121 3248 835267 SGTC_3283 9109332 35.8195 µM -0.384171472956012 0.403338845406806 no 2003 0.350425680160748 3095 17027281 SGTC_619 1652-1634 108 µM -0.384819495948581 0.403101747663995 no 2004 0.350185576862242 3096 5400454 SGTC_1370 2001-0092 44.6 µM -0.384984980379879 0.403041206158798 no 2005 0.350124271720421 3300 790957 SGTC_2238 6671620 73.2395 µM -0.386312828288327 0.402555505083468 no 2006 0.349632500473911 3007 729941 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.386529751589577 0.402476173006322 no 2007 0.349552186421939 3243 1273210 SGTC_295 k015-0027 31 µM -0.386563342588601 0.402463888637467 no 2008 0.349539750235361 3154 3887424 SGTC_3231 9132313 49.47 µM -0.386673105472395 0.402423748563338 no 2009 0.349499114531806 3137 4905967 SGTC_646 4092-0839 27.3 µM -0.386704301977942 0.402412340249384 no 2010 0.349487565478407 3232 877796 SGTC_2107 5363541 170.161 µM -0.386852686210757 0.402358078453628 no 2011 0.349432635033795 3191 244052 SGTC_152 4469-0003 551.229 µM -0.387859521290095 0.401989944337961 no 2012 0.349059997510253 3184 697280 SGTC_2517 totarol 10 µM -0.388009534789985 0.401935101589705 no 2013 0.349004488788546 3179 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1854 st056233 32.9 µM -0.389222322922175 0.40149179492732 no 2014 0.348555845787288 3178 5393174 SGTC_2920 7982904 15.77 µM -0.389335526636729 0.401450422385854 no 2015 0.348513979479014 3163 6456808 SGTC_3146 9095609 49.47 µM -0.389404493905118 0.401425217472036 no 2016 0.34848847410986 3132 17173999 SGTC_2126 5251174 33.877 µM -0.389921679196659 0.40123621899317 no 2017 0.348297231275483 3270 790722 SGTC_716 1683-5115 658 µM -0.390306990553536 0.401095427105743 no 2018 0.348154777353768 3127 723597 SGTC_2499 avocadenofuran 51.48 µM -0.391042392689286 0.400826748511613 no 2019 0.347882950427462 3044 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2303 7774051 200 µM -0.391794805153788 0.40055190375283 no 2020 0.347604916860563 3267 2953184 SGTC_756 0508-1999 28.3 µM -0.392711673078628 0.400217052490041 no 2021 0.347266224038284 3081 6753853 SGTC_1488 4013-0813 75.9 µM -0.394130476240196 0.399699033038133 no 2022 0.34674235575961 3107 2910057 SGTC_1793 st048256 72.231 µM -0.394277262923784 0.39964544978737 no 2023 0.3466881740429 3084 672022 SGTC_745 0469-0705 296 µM -0.394622797339355 0.399519322802528 no 2024 0.346560643192581 3316 3486736 SGTC_968 1309-0633 340 µM -0.395031562763983 0.399370128772702 no 2025 0.34640979731045 3210 3761976 SGTC_1055 3448-0672 86 µM -0.395258309159312 0.399287375641456 no 2026 0.346326132045517 3243 748378 SGTC_705 1124-0212 310 µM -0.395427988875188 0.399225452466885 no 2027 0.346263528244285 3254 9554485 SGTC_371 0195-0006 7.36 µM -0.396475835229941 0.398843106052923 no 2028 0.345877015548349 3052 3928593 SGTC_2742 clothiapine 36.27 µM -0.398530011817182 0.398093843884939 no 2029 0.345119770136585 3160 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_362 0310-0100 9.03 µM -0.400175847304746 0.397493795281044 no 2030 0.344513501355915 3228 790235 SGTC_1277 0873-0036 22 µM -0.400300610851073 0.397448318106574 no 2031 0.34446755904666 3211 5965735 SGTC_1631 benzylvanillin 81.9 µM -0.401377716587741 0.397055763650473 no 2032 0.344071026446305 3233 75506 SGTC_1487 3970-0795 2.82 µM -0.401908287539322 0.396862433764427 no 2033 0.343875761643543 3201 3765103 SGTC_2882 9058044 58.44 µM -0.403584941516587 0.396251660006721 no 2034 0.343258980434178 3190 18076804 SGTC_3152 9099253 49.47 µM -0.404211456874179 0.396023497403448 no 2035 0.343028614776429 3150 25236131 SGTC_1505 k297-0037 20.6 µM -0.404887464480733 0.395777350801007 no 2036 0.342780116565487 3124 4089396 SGTC_2221 6807166 181.081 µM -0.405122836075626 0.395691657493169 no 2037 0.342693610684568 3171 674925 SGTC_294 k038-0071 157 µM -0.405512003808105 0.395549981660819 no 2038 0.342550598362388 3164 24152826 SGTC_552 k242-0005 476 µM -0.405602113729544 0.395517179268686 no 2039 0.34251748776225 3241 4088318 SGTC_3015 9080845 49.47 µM -0.406511367563313 0.395186228303469 no 2040 0.342183453122314 3251 5296973 SGTC_690 glyoxal 20.3 µM -0.408162658084833 0.394585383660016 no 2041 0.341577130607923 3179 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_774 k060-0086 136 µM -0.408198860803057 0.394572213608887 no 2042 0.341563842228767 3305 5911235 SGTC_783 0848-0141 92.7 µM -0.408280284460391 0.394542593242165 no 2043 0.341533956007301 3148 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1658 st012944 20 µM -0.409433161812294 0.394123264056294 no 2044 0.341110903774919 3183 24207260 SGTC_15 0266-0086 27.098 µM -0.409676875923476 0.394034635074415 no 2045 0.341021497607118 3227 1712902 YIL048W NEO1 SGTC_377 3970-0964 33.1 µM -0.41096367694585 0.393566768577708 no 2046 0.340549584612733 3126 16481235 SGTC_1675 st018485 24.5 µM -0.41103154245635 0.393542097694104 no 2047 0.340524702979527 3146 3323024 SGTC_2164 5685496 200 µM -0.411239082610691 0.393466654085838 no 2048 0.34044861653069 3260 759046 SGTC_2859 9028643 45.46 µM -0.412301011893826 0.393080691304911 no 2049 0.34005940353012 3170 17151580 SGTC_722 3534-0461 190 µM -0.412404689192801 0.39304301496734 no 2050 0.340021413368918 3161 658262 SGTC_2753 fluvastatin 17.09 µM -0.412425768000262 0.393035355049803 no 2051 0.340013689723505 3188 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_669 0108-0021 26.2 µM -0.41245805302737 0.393023622936721 no 2052 0.340001860052496 3436 17201 SGTC_647 0140-0236 81 µM -0.413816478876308 0.39253007034836 no 2053 0.339504257312861 3166 990837 SGTC_2875 9039966 71.43 µM -0.413819938729687 0.392528813510992 no 2054 0.339502990296361 3180 6463691 SGTC_1339 1486-1321 22.7 µM -0.414092550607707 0.392429787175547 no 2055 0.339403164096815 3142 3469382 SGTC_2839 9003951 25.97 µM -0.414973849015667 0.392109702981712 no 2056 0.339080523552782 3242 2990634 SGTC_3143 9086658 49.47 µM -0.414989033902064 0.392104188528421 no 2057 0.339074965447433 3175 25236626 SGTC_1662 st014054 52 µM -0.415240812056071 0.392012757426507 no 2058 0.338982812504171 3173 2838777 SGTC_1826 st055655 41.6 µM -0.416684571849511 0.391488583569451 no 2059 0.33845457031402 3204 676168 SGTC_2240 6690706 185.951 µM -0.418710034030531 0.39075354805423 no 2060 0.337714030796501 3025 805876 SGTC_1063 disulfiram 1.84 µM -0.419700905506275 0.390394105059502 no 2061 0.337351981762906 3152 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1901 st060216 58.6 µM -0.422652744042941 0.389323868865464 no 2062 0.336274319182534 3129 688792 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.424730873904456 0.388570912425236 no 2063 0.335516437252884 3099 688667 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.42511097030418 0.388433239544358 no 2064 0.335377890550395 3199 5379071 SGTC_810 3825-7150 143 µM -0.427160043759126 0.387691296386668 no 2065 0.334631380869551 3314 22330411 YGL099W LSG1 SGTC_1738 st035555 74 µM -0.427639854933536 0.387517622057051 no 2066 0.334456672392321 3243 5331140 SGTC_445 e6 berbamine 66 µM -0.42935496492716 0.386896998372217 no 2067 0.333832461146941 3242 6610268 A calcium/calmodulin antagonist. SGTC_2865 9030313 51.95 µM -0.429369054106223 0.386891901306309 no 2068 0.333827335315934 3097 42562754 SGTC_1938 st074717 56.4 µM -0.429534355155032 0.386832101526275 no 2069 0.33376719890891 3197 17250979 SGTC_272 doxorubicin 8.13 µM -0.42982580437007 0.386726672569974 no 2070 0.33366118028779 3233 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_431 k089-0097 107 µM -0.430026375609596 0.386654122704303 no 2071 0.333588227481931 3221 5499420 SGTC_364 0083-0097 67.7 µM -0.430259227351782 0.386569901426959 no 2072 0.333503541337728 3279 5207356 SGTC_1400 3771-8998 51.5 µM -0.431847010566793 0.385995751020685 no 2073 0.332926304813262 3152 670767 SGTC_2455 5377712 9.75 µM -0.432418384503429 0.385789200336767 no 2074 0.332718679308889 3227 2243908 SGTC_2700 st077718 96.8 µM -0.437132129597167 0.384086430116056 no 2075 0.331007763680051 3215 904970 SGTC_1596 piperlongumine 63 µM -0.439935949305138 0.383074649868804 no 2076 0.329991748978277 3312 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1557 sumaresinolic acid 42.3 µM -0.44284422962563 0.382026016436741 no 2077 0.328939204517354 3163 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_249 wiskostatin 11.211 µM -0.443153924022558 0.381914401302387 no 2078 0.328827201773754 3288 2775510 A n-wasp and actin depolymerizer. SGTC_654 1124-0271 80.9 µM -0.443209611943304 0.381894332187572 no 2079 0.328807063550016 3194 5403748 SGTC_1588 farnesol 29.9 µM -0.443632830052706 0.381741820926444 no 2080 0.32865403294374 3178 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3203 9113543 49.47 µM -0.444095193965239 0.381575224028447 no 2081 0.328486880522274 3290 17018012 SGTC_147 4466-0538 29.23 µM -0.444539834953347 0.381415033665584 no 2082 0.328326167609692 3372 6742687 YHR072W ERG7 SGTC_87 0100-0052 35.5 µM -0.446214061766849 0.380812044093927 no 2083 0.327721313193965 3308 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1345 1488-0192 31.4 µM -0.447291793253129 0.380424041288663 no 2084 0.327332195841933 3307 658348 SGTC_2012 4023501 200 µM -0.44741288091608 0.380380455050913 no 2085 0.327288488583725 3226 3477460 SGTC_3068 9116768 49.47 µM -0.448011980757607 0.380164827789072 no 2086 0.32707227504835 3281 41904888 SGTC_1228 0124-0032 52.5 µM -0.449797360330148 0.379522457310506 no 2087 0.326428280683125 3281 X1228 SGTC_1221 2958-7315 257 µM -0.450777577635323 0.379169921345138 no 2088 0.326074931653975 3281 4562705 SGTC_2341 7987486 176.74 µM -0.45158347817069 0.378880153790082 no 2089 0.325784537300007 3331 1258686 SGTC_1571 st070080 73.4 µM -0.452594616044754 0.378516687901519 no 2090 0.325420338175534 3358 4315245 SGTC_1945 st075991 56.6 µM -0.453314785187492 0.378257879780434 no 2091 0.325161043910782 3215 1084980 SGTC_1527 coumarin 137 µM -0.455924215927161 0.377320583474724 no 2092 0.324222237619186 3342 323 A hepatotoxic, DNA x-linker. SGTC_1334 1486-0610 236 µM -0.456001658188216 0.377292777555366 no 2093 0.324194392909062 3285 3742339 SGTC_314 1671-0008 2.74 µM -0.456145686817203 0.377241065255568 no 2094 0.324142609388594 3224 3913060 SGTC_866 0495-0101 262 µM -0.457135212410739 0.376885843753474 no 2095 0.323786931037521 3194 635694 SGTC_1863 st057641 20.1 µM -0.460982554682823 0.375505711156434 no 2096 0.322405560648837 3293 3921635 SGTC_2793 7325131 81.82 µM -0.462844137126248 0.374838487817725 no 2097 0.321738045847255 3225 4176441 SGTC_118 0083-0097 135.343 µM -0.465538792172715 0.373873340610734 no 2098 0.320772831836975 3336 5207356 SGTC_464 bw-b 70c 158 µM -0.467351615685276 0.373224484111461 no 2099 0.320124166673958 3331 5353454 SGTC_2067 5224629 34.075 µM -0.468073031175565 0.372966370671958 no 2100 0.319866182231672 3350 2835000 SGTC_1745 st081495 74 µM -0.469441036992811 0.372477071947909 no 2101 0.319377210745153 3303 13842402 YBL026W LSM2 SGTC_1671 st016596 74.5 µM -0.470254936883881 0.372186059513155 no 2102 0.319086444328081 3316 2829167 SGTC_1096 rimcazole 32.2 µM -0.471216959000179 0.371842179639082 no 2103 0.318742904617499 3207 18528119 A dopamine reuptake inhibitor. SGTC_2651 TUB2.036 5 µM -0.472964809547916 0.371217662983362 no 2104 0.318119142845445 3394 15992207 YFL037W TUB2 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.473055169644987 0.371185386022184 no 2105 0.318086909708944 3231 390807 SGTC_459 nigericin 15.3 µM -0.473310505200646 0.371094184114601 no 2106 0.31799583418912 3361 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3172 9105863 49.47 µM -0.474471417869529 0.370679615434449 no 2107 0.317581887638873 3276 2348785 SGTC_1698 5-fluorocytosine 1.055 µM -0.474595128062608 0.370635446645158 no 2108 0.317537789735871 3340 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3102 9121669 49.47 µM -0.475071828693574 0.370465264089412 no 2109 0.317367888597451 3247 41905072 SGTC_3280 9140961 49.47 µM -0.475665462423262 0.370253371750896 no 2110 0.317156365057281 3206 4901226 SGTC_1749 st037932 54.2 µM -0.477124385729779 0.369732789288212 no 2111 0.316636775432056 3336 594497 SGTC_2335 9018011 154.17 µM -0.478213685076479 0.36934425400561 no 2112 0.316249061591844 3288 6458208 SGTC_1274 0865-0114 173 µM -0.47835783005643 0.369292849832848 no 2113 0.316197771251786 3279 870624 SGTC_2154 5570129 200 µM -0.479287602416469 0.368961335826886 no 2114 0.315867020318646 3336 673366 SGTC_373 0844-0104 25.9 µM -0.479849020211346 0.368761207270649 no 2115 0.315667376687118 3350 5375804 SGTC_1157 4092-0394 27.6 µM -0.480359730502922 0.368579185319969 no 2116 0.315485811664994 3430 3659885 SGTC_2236 dapsone 200 µM -0.481087259793701 0.368319937963535 no 2117 0.3152272412201 3330 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2108 5365811 200 µM -0.484526424278767 0.36709524133904 no 2118 0.314006157908432 3326 780283 SGTC_43 0570-0105 72.5 µM -0.485131580844547 0.366879882738403 no 2119 0.313791505699553 3269 1114046 YDL195W SEC31 SGTC_1304 1165-0502 251 µM -0.485552006589221 0.366730289419219 no 2120 0.313642415571633 3248 767425 SGTC_2790 5423970 71.43 µM -0.487224858278746 0.366135266234803 no 2121 0.313049495518762 3374 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2602 kawain 100 µM -0.489605212801422 0.365289143527601 no 2122 0.312206643519511 3350 5369129 SGTC_2352 9027995 87.8 µM -0.490869261403179 0.364840089920485 no 2123 0.311759459508958 3292 2997347 SGTC_1724 st037281 8.293 µM -0.491030339180148 0.364782880298034 no 2124 0.311702494742302 3254 574124 YDL195W SEC31 SGTC_485 niflumic acid 177 µM -0.491749168354625 0.36452761211106 no 2125 0.311448337472655 3368 4488 A COX2 inhibitor. SGTC_168 3970-0862 530.542 µM -0.49195985234529 0.364452806101145 no 2126 0.311373862705509 3325 3135186 SGTC_1265 0819-1001 68.8 µM -0.492109781617194 0.36439957496457 no 2127 0.31132086884869 3370 3106768 SGTC_950 1165-0508 94.1 µM -0.492241205824157 0.364352916047678 no 2128 0.311274418990119 3314 6148369 SGTC_414 piperonyl butoxide 100 µM -0.492299033630297 0.364332386350921 no 2129 0.311253981596031 3253 5794 A potent inhibitor of cytochrome P450. SGTC_381 3461-2219 42.7 µM -0.493260754609663 0.36399101877544 no 2130 0.3109141773204 3340 2883159 SGTC_2652 actinonin 100 µM -0.494590106662648 0.36351933644841 no 2131 0.310444743575666 3253 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3115 9123671 49.47 µM -0.494637887851242 0.363502386514778 no 2132 0.310427876357553 3400 3286988 SGTC_164 4100-3994 89.624 µM -0.495867068874854 0.363066437883916 no 2133 0.309994100777912 3416 4615967 SGTC_2014 4013930 200 µM -0.497779981997447 0.36238834572885 no 2134 0.309319563394206 3388 64556 SGTC_1330 1469-0054 61.8 µM -0.499674368490241 0.361717246137954 no 2135 0.308652191621244 3379 7102664 SGTC_1128 3448-9350 235 µM -0.500035489635421 0.361589364637549 no 2136 0.308525044166755 3294 619386 SGTC_2175 5807670 165.306 µM -0.500551037886103 0.361406823653705 no 2137 0.308343564125439 3357 241186 SGTC_3304 9125678 46.087 µM -0.501777549606735 0.360972677570206 no 2138 0.307912003493494 3266 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1856 st057054 55.7 µM -0.502048208885957 0.360876896902989 no 2139 0.307816805015621 3459 1266018 SGTC_3084 9116877 49.47 µM -0.502807414731552 0.360608276383537 no 2140 0.307549840021206 3321 27241325 SGTC_2112 5488546 200 µM -0.503390525007235 0.360402008290134 no 2141 0.307344865949829 3267 600757 SGTC_1503 4585-0012 61.3 µM -0.503583819704044 0.360333641628397 no 2142 0.307276932554136 3412 2922052 SGTC_532 1548-0774 215 µM -0.503766445230185 0.360269052662567 no 2143 0.307212754911963 3489 5932993 SGTC_2241 6772625 37.8075 µM -0.504388482635611 0.360049087321971 no 2144 0.306994204951977 3363 2285411 SGTC_1310 1188-0297 994 nM -0.504814280773835 0.3598985429681 no 2145 0.306844642272754 3293 1588352 SGTC_2733 amorolfine 100 µM -0.505878857514246 0.359522248435094 no 2146 0.306470847681061 3347 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2931 9014674 55.67 µM -0.507984042134375 0.358778532801112 no 2147 0.30573226723335 3240 2996810 SGTC_2761 levamisole 97.89 µM -0.508064842129147 0.358749998577532 no 2148 0.305703935175478 3419 26879 An alkaline phosphatase inhibitor. SGTC_1347 1493-0251 600 nM -0.510473524299546 0.357899743915283 no 2149 0.304859879214452 3404 3986378 SGTC_856 0433-0016 11.3 µM -0.511861992523729 0.35740994027981 no 2150 0.304373800006316 3365 3911780 SGTC_880 0833-0487 87.2 µM -0.512826258736119 0.357069918566838 no 2151 0.304036429889524 3347 76075 SGTC_2160 5660466 132.927 µM -0.513144452854973 0.35695774113418 no 2152 0.303925139143627 3378 2859134 SGTC_2357 9067248 200 µM -0.513241130285826 0.356923660533392 no 2153 0.303891329095924 3381 9150235 SGTC_2922 7999257 32.47 µM -0.513368649994546 0.356878709199713 no 2154 0.30384673544727 3386 2988377 SGTC_2850 9015429 58.44 µM -0.51351659692602 0.356826559658178 no 2155 0.303795002055914 3324 6457570 SGTC_104 0074-0074 590.992 µM -0.516357928486942 0.355825544083546 no 2156 0.302802222036596 3301 3943124 SGTC_3045 9092950 49.47 µM -0.516785083226911 0.355675141012482 no 2157 0.30265309705796 3443 44120432 SGTC_2155 5570423 76 µM -0.517655291777323 0.355368806264024 no 2158 0.302349398392265 3295 797402 SGTC_469 w7 172 µM -0.519054830491695 0.354876330332075 no 2159 0.301861252952388 3386 45115570 A P450 inhibitor. SGTC_1970 st070122 35.8 µM -0.519320439002315 0.354782894165026 no 2160 0.301768651296404 3456 102928 SGTC_2031 5180455 200 µM -0.519835303328011 0.354601799288296 no 2161 0.301589185561584 3340 29949 SGTC_1354 1498-1681 81 µM -0.5201750344878 0.35448232255203 no 2162 0.301470792114686 3385 5754243 SGTC_2412 st077135 33.4 µM -0.520506388191766 0.354365805793164 no 2163 0.30135533829362 3507 13258915 SGTC_1942 st076330 65.2 µM -0.520664798792188 0.354310107323235 no 2164 0.301300150202747 3448 24208414 SGTC_2375 9072683 200 µM -0.521389482916274 0.354055342176266 no 2165 0.301047738201238 3460 16798029 SGTC_2086 5274770 176.623 µM -0.522548035427079 0.353648184858883 no 2166 0.300644405249941 3364 689278 SGTC_2330 7979373 200 µM -0.522928873205749 0.353514381197421 no 2167 0.300511875490034 3307 1863007 SGTC_2041 5107442 45.335 µM -0.523292034312798 0.353386804921399 no 2168 0.300385521710542 3454 793005 SGTC_1872 amphotericin b 148 nM -0.523561957985849 0.353291993055648 no 2169 0.30029162336365 3377 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2102 5377816 72.7585 µM -0.52684645587611 0.352139029863446 no 2170 0.299150109647499 3450 1379702 SGTC_1000 4048-0884 8.67 µM -0.527422443669018 0.3519369794755 no 2171 0.298950130607641 3415 13040088 SGTC_865 0488-0499 301 µM -0.527855974212377 0.351784929143471 no 2172 0.298799651817486 3458 9634651 SGTC_1056 3448-1962 115 µM -0.527859333350835 0.351783751099573 no 2173 0.298798485992306 3387 715507 SGTC_1672 st016598 6.51 µM -0.527935650415094 0.351756987223969 no 2174 0.29877199989022 3330 4665860 YNL267W PIK1 SGTC_1651 st011928 86.1 µM -0.529263669486463 0.351291377687197 no 2175 0.298311277208223 3417 720198 SGTC_1625 st003711 30.1 µM -0.530243116325879 0.350948122063465 no 2176 0.297971690242608 3482 24207034 YER133W GLC7 SGTC_781 4335-2806 94.4 µM -0.530459554365827 0.350872285873737 no 2177 0.297896672135477 3447 845254 SGTC_2222 6885208 172.143 µM -0.530597312978991 0.35082402070389 no 2178 0.297848929050923 3371 609514 SGTC_542 3381-0244 89.3 µM -0.531145827446296 0.350631866808915 no 2179 0.297658864681493 3461 1112843 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.532132807113479 0.350286207396585 no 2180 0.297317008305906 3412 279621 SGTC_286 k060-0067 22.9 µM -0.532611187158524 0.350118714018373 no 2181 0.297151378207648 3346 5985051 SGTC_2788 5282734 71.43 µM -0.532890285774608 0.350021007749027 no 2182 0.297054765046771 3454 743706 SGTC_723 4182-0001 115 µM -0.533320441529788 0.349870439152173 no 2183 0.296905889877995 3346 744821 YLR208W SEC13 SGTC_3289 9119912 71.43 µM -0.535266482779045 0.349189556272654 no 2184 0.296232799870329 3456 17014829 SGTC_7 0192-1582 4.227 µM -0.535439834025523 0.349128927464352 no 2185 0.29617287570651 3412 252616 SGTC_3295 9122362 53.5725 µM -0.537174416146884 0.348522477531404 no 2186 0.295573570783273 3416 4730473 SGTC_1287 0971-0001 34.6 µM -0.538102559983621 0.348198135846415 no 2187 0.295253122600648 3430 4665869 SGTC_2438 5259590 200 µM -0.538158572517168 0.348178565705709 no 2188 0.295233788997213 3396 1201127 SGTC_955 1216-0110 33 µM -0.538758880229052 0.347968850427959 no 2189 0.295026619987325 3390 3619719 SGTC_2459 5811157 9.22 µM -0.542867761238393 0.346534679217524 no 2190 0.293610427142166 3424 2870684 YBR192W RIM2 SGTC_1883 5-benzylidenerhodanine 20 µM -0.542961556098495 0.346501966463071 no 2191 0.293578135986918 3411 1273210 SGTC_1984 st072354 53.1 µM -0.545468061976207 0.345628199251612 no 2192 0.292715820338537 3334 5762938 SGTC_1559 coumarin 343 70.1 µM -0.546000344138214 0.345442751474878 no 2193 0.292532850325402 3480 108770 A hepatotoxic, DNA x-linker. SGTC_3009 9080819 71.4286 µM -0.546325178537457 0.345329596983249 no 2194 0.292421215830705 3406 17027216 SGTC_2571 chrysanthemic acid 100 µM -0.5471310257383 0.34504894371103 no 2195 0.292144359201967 3366 2743 An insecticide. SGTC_2050 5263056 171 µM -0.547436490830234 0.344942581318873 no 2196 0.292039445595623 3453 763468 YGL055W OLE1 SGTC_576 1073-0113 22.7 µM -0.547563692410096 0.344898293571537 no 2197 0.2919957627113 3565 5439563 SGTC_3346 9158254 43.5805 µM -0.547979224752501 0.34475363257487 no 2198 0.291853084028681 3410 17639500 SGTC_1289 0976-0073 69.1 µM -0.549456781733791 0.34423942849282 no 2199 0.291346007977723 3458 3391136 SGTC_278 4092-0821 23.9 µM -0.549635554017683 0.344177233513635 no 2200 0.291284683822816 3430 877900 SGTC_1741 st038134 10.228 µM -0.549879857030601 0.344092247171793 no 2201 0.291200890442652 3537 1272587 SGTC_1575 cyproterone acetate 48 µM -0.550146058190238 0.343999652027931 no 2202 0.291109599041558 3370 9880 An androgen receptor antagonist and liver toxin. SGTC_1140 3229-1848 2.98 µM -0.550284346570383 0.343951553628301 no 2203 0.291062179505463 3452 2849525 SGTC_400 oxethazaine 37.5 µM -0.550308890764048 0.343943017119672 no 2204 0.291053763598524 3414 4621 A local anesthetic. SGTC_1818 st052136 56.3 µM -0.551798389248925 0.343425116271201 no 2205 0.290543245494501 3426 674169 SGTC_392 N-ethylmaleimide 8.33 µM -0.553600284317416 0.342798987456465 no 2206 0.289926215707254 3362 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.554780344541596 0.342389169729773 no 2207 0.289522456480108 3459 5024745 SGTC_1316 1272-0050 65.9 µM -0.555330588240347 0.342198141494594 no 2208 0.289334280151496 3451 7340392 SGTC_1635 st007035 42.4 µM -0.556540356062386 0.341778288137681 no 2209 0.28892075719203 3458 3716403 SGTC_2133 5320837 200 µM -0.558048997452968 0.341254983993814 no 2210 0.288405463246165 3462 2841355 SGTC_1769 st044406 64.4 µM -0.558164521917439 0.341214924457134 no 2211 0.288366022391088 3361 670903 SGTC_2830 7992007 71.43 µM -0.558779450185808 0.341001720598274 no 2212 0.288156124411633 3387 1952075 SGTC_2774 tamoxifen 10.92 µM -0.559294350998548 0.340823236641186 no 2213 0.287980425005253 3485 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_617 3770-0098 35 µM -0.560562620563059 0.340383758801755 no 2214 0.287547869709824 3407 5962639 SGTC_1917 st066507 28.5 µM -0.56128517530911 0.340133477647379 no 2215 0.287301573028123 3339 3156428 SGTC_1494 4358-1428 177 µM -0.562149224035092 0.339834277755833 no 2216 0.287007176526908 3497 1564571 SGTC_3057 9095946 49.47 µM -0.563045354138411 0.339524075389463 no 2217 0.286702000363103 3455 24540043 SGTC_1060 3448-7350 82 µM -0.564659219138676 0.338965697769701 no 2218 0.286152788708582 3475 570178 SGTC_3276 9139060 49.47 µM -0.566091279128717 0.338470518498023 no 2219 0.28566586567843 3480 4870619 SGTC_1497 4476-2978 41.3 µM -0.566599657829678 0.338294797852225 no 2220 0.28549310375029 3478 1528379 SGTC_1393 3470-5649 58.2 µM -0.566624185133224 0.338286320901708 no 2221 0.285484769914247 3395 4108395 SGTC_2408 sulbentine 18.36 µM -0.568368037658908 0.337683833423912 no 2222 0.284892544397616 3328 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_535 2293-4129 48.2 µM -0.569368200183688 0.337338472544128 no 2223 0.284553146295536 3500 396118 YIL048W NEO1 SGTC_2990 9074105 71.4286 µM -0.569798444750559 0.33718994917354 no 2224 0.284407205257928 3441 6502001 SGTC_1782 st039423 80.636 µM -0.570152078409 0.337067891408867 no 2225 0.284287277795769 3377 2068169 SGTC_2478 5763493 32.33 µM -0.57029429258733 0.337018810574815 no 2226 0.28423905564645 3429 1365576 YLR208W SEC13 SGTC_207 4185-0010 4.486 µM -0.571011619747067 0.336771289553602 no 2227 0.283995883143442 3526 3761753 SGTC_61 0978-8327 98.565 µM -0.573640332465855 0.335864830363078 no 2228 0.283105606449454 3492 6150059 YHR072W ERG7 SGTC_1344 1488-0097 29.1 µM -0.574150955002504 0.335688862847781 no 2229 0.282932827332868 3484 747966 SGTC_784 4579-0127 173 µM -0.574684544265885 0.33550501917456 no 2230 0.282752331091051 3527 1948547 SGTC_1730 st033808 45.1 µM -0.574720657847272 0.335492577967365 no 2231 0.282740117016516 3361 1045166 SGTC_566 0958-0068 16.5 µM -0.575303783032038 0.335291715053731 no 2232 0.282542931731667 3495 6815365 SGTC_1798 st045719 60.953 µM -0.575446545531085 0.335242546350041 no 2233 0.282494666301152 3451 3980186 SGTC_2016 5121758 140 µM -0.576522883856738 0.334871936546815 no 2234 0.282130903373022 3481 2795203 SGTC_463 ikarugamyin 104 µM -0.576771666873866 0.334786297285222 no 2235 0.28204685592268 3490 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_360 0957-0399 1.01 µM -0.577180798267735 0.334645479546422 no 2236 0.281908663506171 3493 6752301 YPR165W RHO1 SGTC_2848 9016370 25.97 µM -0.57969000507741 0.333782352276867 no 2237 0.281061842364597 3524 7894410 SGTC_1216 1165-0504 9.65 µM -0.581349222621204 0.333212090156147 no 2238 0.280502556185317 3515 6304004 SGTC_1040 k898-0338 155 µM -0.581752044917083 0.333073700878669 no 2239 0.280366854850401 3549 20969351 SGTC_424 splitomicin 100 mM -0.582379495443167 0.33285818603156 no 2240 0.280155544903025 3453 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2639 lactacystin 53 µM -0.582718440247103 0.332741789236506 no 2241 0.280041428718997 3525 3870 A proteasome inhibitor. SGTC_2323 6148992 148.28 µM -0.58802608878113 0.330921202130125 no 2242 0.278257390867623 3417 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_832 4083-0019 164 µM -0.589037775037852 0.330574633200579 no 2243 0.277917966787201 3548 1990758 SGTC_1840 st055363 71 µM -0.589641711075371 0.330367814678577 no 2244 0.277715440622888 3452 676033 SGTC_1102 cgs 12066b 26.1 µM -0.5902245592179 0.330168266848559 no 2245 0.277520054526575 3465 6438352 A 5-HT1B full agonist. SGTC_1406 3909-7906 11.9 µM -0.59064304866617 0.330025019757595 no 2246 0.277379807253623 3525 X1406 SGTC_1702 st027038 51 µM -0.591877192715669 0.32960272285539 no 2247 0.276966413684194 3497 5521182 SGTC_226 1,3-diallylurea 8.28947 mM -0.592170886079626 0.329502259428292 no 2248 0.276868081490685 3462 74537 YKL182W FAS1 SGTC_2275 7947463 200 µM -0.592604668168958 0.329353898485429 no 2249 0.276722877130298 3491 1225414 SGTC_2881 9058953 51.95 µM -0.592877037844505 0.329260757094339 no 2250 0.276631723087789 3448 17122249 SGTC_811 0416-0114 265 µM -0.59411264593822 0.328838353260275 no 2251 0.276218386653023 3521 6612453 SGTC_2386 9075165 157.42 µM -0.594673649026562 0.328646641367632 no 2252 0.276030819625435 3478 16452277 SGTC_1182 1222-0449 220 µM -0.595339557593442 0.328419138596348 no 2253 0.275808259475909 3481 658318 SGTC_1521 st012942 49.4 µM -0.596304760859833 0.328089496911576 no 2254 0.275485825581403 3515 24207259 SGTC_966 1300-0360 30.2 µM -0.596871726615149 0.327895925942058 no 2255 0.275296512606467 3468 70588 SGTC_3285 9112818 20.8695 µM -0.598064514549639 0.327488840475546 no 2256 0.27489844335085 3525 17017947 YPR165W RHO1 SGTC_1280 0880-0253 10.1 µM -0.600394262221947 0.326694314736007 no 2257 0.274121755419107 3467 6836607 SGTC_1179 1021-1431 9.29 µM -0.600643377036655 0.326609404252652 no 2258 0.274038770081886 3478 2840958 SGTC_976 1348-1067 47.6 µM -0.601647540649235 0.326267227403954 no 2259 0.273704388180755 3546 5310671 YGL099W LSG1 SGTC_2581 avocatin a 64 µM -0.602051046085453 0.326129770829209 no 2260 0.273570079580814 3466 6710728 A skin care supplement. SGTC_569 4130-2812 160 µM -0.602170191560097 0.326089187716409 no 2261 0.273530427711582 3457 743552 SGTC_1466 k213-0079 57.5 µM -0.602423032731511 0.326003072244593 no 2262 0.273446291052458 3496 3657981 SGTC_454 lyso-paf C-16 6.67 µM -0.602478759330426 0.325984093504608 no 2263 0.273427748921398 3468 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_681 1642-0006 26.6 µM -0.604941245927261 0.325145898138137 no 2264 0.27260901810796 3534 4446530 SGTC_1829 berberine 14.4 µM -0.607693726668634 0.324210039206537 no 2265 0.271695312258556 3563 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_346 4513-0042 7.16 µM -0.608281700278518 0.324010268499284 no 2266 0.271500327968093 3539 2827372 SGTC_3215 9129942 49.47 µM -0.608557683528184 0.323916517528462 no 2267 0.271408830218414 3493 17682944 SGTC_2937 9044753 11.33 µM -0.608643773122386 0.323887275346569 no 2268 0.271380291760151 3523 6465530 YGL099W LSG1 SGTC_2367 9070478 135.38 µM -0.608701780043177 0.323867572661475 no 2269 0.271361063472314 3516 572802 SGTC_2051 5263410 176 µM -0.610297825265786 0.323325652204636 no 2270 0.270832268644266 3594 227584 SGTC_697 0508-1955 564 µM -0.610463476976283 0.323269428339522 no 2271 0.27077741510828 3540 6243113 SGTC_342 k048-0088 23.3 µM -0.611043069293751 0.32307274062191 no 2272 0.270585533869397 3494 6820570 SGTC_1236 0330-0013 258 µM -0.611155945755528 0.323034441150256 no 2273 0.2705481726174 3481 4617066 SGTC_2491 paeonol 100 µM -0.612359816699791 0.322626079315756 no 2274 0.270149860860538 3506 11092 Increases levels of cortical cytochrome oxidase. SGTC_1725 st036284 20.55 µM -0.612906363830604 0.322440757080579 no 2275 0.269969127580688 3574 707914 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.614532366613021 0.321889675916601 no 2276 0.269431795840324 3551 688798 SGTC_2429 5902844 64.44 µM -0.614587568962243 0.321870973726718 no 2277 0.269413562988714 3515 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3281 9140613 49.47 µM -0.615067780208942 0.321708300380647 no 2278 0.269254979526457 3498 16013766 SGTC_860 0443-0016 25.1 µM -0.615641410934186 0.321514025632126 no 2279 0.269065606894322 3544 5337942 SGTC_1089 terbinafine 2.25 µM -0.616408937169554 0.321254159547801 no 2280 0.268812328158271 3547 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2529 gangaleoidin 93.61 µM -0.62121017345925 0.319630564975218 no 2281 0.267230673286152 3568 4565183 SGTC_2956 9076196 2.52 µM -0.621414393723035 0.319561581787126 no 2282 0.26716350198268 3598 16423868 SGTC_132 0417-1715 25.805 µM -0.624155891733071 0.318636141431466 no 2283 0.266262605484096 3608 6769098 SGTC_2468 5987765 72.9 µM -0.625064358447915 0.318329721689908 no 2284 0.265964409542872 3529 26772094 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.626300882013533 0.317912850251602 no 2285 0.265558803965742 3559 16486 A toxic proline analog. SGTC_422 cantharidin 155 µM -0.62703769567944 0.317664556548013 no 2286 0.265317262952277 3540 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_652 0437-0092 114 µM -0.627259151819171 0.317589945605179 no 2287 0.265244687376171 3557 3091274 SGTC_113 0099-0221 2.5 µM -0.629251237244063 0.316919124067068 no 2288 0.264592294864086 3610 89219 SGTC_3124 9127567 49.47 µM -0.636141285495264 0.314603594110672 no 2289 0.262342169146628 3557 17592030 SGTC_862 0452-0056 10.2 µM -0.638802478870514 0.313711191942655 no 2290 0.26147571773801 3533 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1061 3448-9325 110 µM -0.639078438461926 0.31361871413013 no 2291 0.261385952889461 3564 723482 SGTC_73 0327-0325 16.231 µM -0.639501877447917 0.313476836740631 no 2292 0.261248246343534 3620 53298 SGTC_941 3237-0776 460 µM -0.641642754495872 0.312759937631787 no 2293 0.260552583051309 3597 760008 SGTC_1022 4477-0945 21.3 µM -0.642519365090684 0.312466597796754 no 2294 0.260268009918325 3570 4648966 SGTC_2556 citropten 84.59 µM -0.643609026127465 0.312102130590902 no 2295 0.259914497855272 3549 2775 A potential DNA crosslinker. SGTC_2037 5169046 200 µM -0.643814604956584 0.312033389681446 no 2296 0.259847830955657 3588 5718022 SGTC_537 1334-0398 209 µM -0.644124457735316 0.311929794289724 no 2297 0.25974736585971 3583 5846986 SGTC_139 0099-0334 718.624 µM -0.644941403766802 0.311656729957018 no 2298 0.259482579546124 3625 97690 SGTC_2312 7706453 155.7 µM -0.6453531962247 0.311519127503797 no 2299 0.25934916336515 3595 976098 SGTC_1362 1611-0397 101 µM -0.646592926293423 0.311105024631672 no 2300 0.258947718669353 3586 27816 SGTC_317 4495-0002 170 µM -0.652151194491648 0.309251358815914 no 2301 0.257151820498471 3564 15991618 SGTC_1132 3456-3614 2.5 µM -0.653946195044534 0.308653764096662 no 2302 0.256573235364063 3650 3125502 SGTC_2771 fluoxetine 41.05 µM -0.657439646695587 0.307492170872435 no 2303 0.255449132983875 3619 3386 A selective serotonin reuptake inhibitor. SGTC_683 panaxydol 45 µM -0.657511135554628 0.307468420497656 no 2304 0.255426156617433 3591 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1295 1013-0063 9.78 µM -0.658565061096398 0.307118373961923 no 2305 0.255087552559438 3609 6826038 SGTC_117 lucigenin 22.078 µM -0.659499900687418 0.306808027175825 no 2306 0.254787404917039 3601 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_84 0443-0269 128.823 µM -0.659906255387709 0.306673169238456 no 2307 0.254656994854717 3574 6150058 SGTC_2523 spermine 47.74 µM -0.662457308557143 0.305827143305613 no 2308 0.253839093120328 3591 1103 A DNA binding polyamine. SGTC_3030 9087619 49.47 µM -0.666904256742307 0.304354843368585 no 2309 0.252416645882369 3590 25236973 SGTC_296 1222-0039 74.9 µM -0.667070149019322 0.304299980692903 no 2310 0.252363663251212 3579 5984176 SGTC_1914 st062367 72.6 µM -0.667214055724339 0.304252392491578 no 2311 0.252317707114965 3610 978205 SGTC_607 4491-0986 66.8 µM -0.668962130877749 0.303674590144421 no 2312 0.251759817513858 3639 698981 YDR232W HEM1 SGTC_1647 st011722 22.4 µM -0.670934620008808 0.303023199642652 no 2313 0.251131090283238 3630 2854783 SGTC_2813 7971799 71.43 µM -0.673233884943794 0.3022646855976 no 2314 0.250399253524314 3652 2234054 SGTC_1612 st002233 45.4 µM -0.673454644100764 0.302191903290335 no 2315 0.250329047260428 3655 1035021 SGTC_2955 9076254 12.21 µM -0.675473691114443 0.30152660695284 no 2316 0.24968743040882 3565 16459619 SGTC_2361 9034121 116 µM -0.675792687981397 0.301421554584118 no 2317 0.249586138894254 3622 6496917 SGTC_2487 5918373 44.05 µM -0.678653909549657 0.300480031755203 no 2318 0.248678588116223 3675 2876279 SGTC_857 0438-0306 1.35 µM -0.679174767093885 0.300308779701173 no 2319 0.248513566627832 3664 4686136 SGTC_1067 clotrimazole 1.36 µM -0.679205968809442 0.300298522331455 no 2320 0.248503682949256 3665 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1909 st060837 51.5 µM -0.681415134410387 0.299572675796938 no 2321 0.24780442457971 3621 678937 SGTC_2464 5717415 7.67 µM -0.682008376808983 0.29937789474967 no 2322 0.247616827009942 3588 5285744 SGTC_2909 7941780 10.49 µM -0.683075282244883 0.299027739110476 no 2323 0.247279636733964 3652 1243215 SGTC_2156 5649887 115 µM -0.68488571270018 0.298433986389831 no 2324 0.246708021183837 3701 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1430 4049-0248 69.1 µM -0.6850702832696 0.298373484370387 no 2325 0.246649785638227 3683 22774488 SGTC_918 glabranin 770.725 nM -0.68512393749905 0.298355897623353 no 2326 0.246632858083668 3674 124049 Also referred to as licorice root. SGTC_1968 st069590 43.6 µM -0.68514242326155 0.298349838481916 no 2327 0.246627026091974 3603 6384066 SGTC_2680 butyl paraben 22.24 µM -0.685493091457232 0.298234909382037 no 2328 0.246516409320906 3681 7184 An antifungal and steroid mimetic. SGTC_850 0388-0143 75.9 µM -0.685767543177229 0.298144973777006 no 2329 0.24642985325531 3624 67273 SGTC_3079 9117512 49.47 µM -0.686046027962929 0.298053729199277 no 2330 0.246342041899082 3670 7185044 SGTC_2806 7952793 58.44 µM -0.686536487685875 0.297893062713479 no 2331 0.246187431750587 3661 2972490 SGTC_3183 9108214 49.47 µM -0.687361144127931 0.297623007970766 no 2332 0.245927588392718 3562 4974831 SGTC_1716 st033144 30.6155 µM -0.688583748732887 0.297222840729168 no 2333 0.245542625412424 3671 674617 SGTC_1073 triclabendazole 3.09 µM -0.688978199511008 0.297093786653337 no 2334 0.245418493326164 3717 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3158 9100007 49.47 µM -0.68924296408315 0.297007176918434 no 2335 0.245335191889791 3675 19297233 SGTC_2605 digitonin 300 nM -0.690057688744897 0.296740736822413 no 2336 0.245078954867682 3698 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_395 anisomycin 6.25 µM -0.690389466861485 0.296632266508904 no 2337 0.244974649419881 3624 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1831 st055328 12 µM -0.690650030482622 0.296547091533833 no 2338 0.24489274935672 3665 1103068 SGTC_500 h-89 112 µM -0.690963298360898 0.296444703036026 no 2339 0.244794302861338 3689 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2778 tioconazole 65.09 nM -0.69211352002376 0.29606890353503 no 2340 0.244433020901578 3626 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1828 st055811 49 µM -0.693553803348707 0.295598643866947 no 2341 0.243981036663769 3625 5877589 SGTC_603 3794-0023 45.9 µM -0.694116086459993 0.295415148875236 no 2342 0.243804705564358 3649 3802260 SGTC_2157 5649910 96.377 µM -0.694969759041306 0.295136662304146 no 2343 0.243537126727181 3648 2858091 SGTC_1888 azatryptophan 97.5 µM -0.695244204654922 0.295047157859273 no 2344 0.243451137010168 3629 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2007 4011539 71.82 µM -0.695675763187603 0.294906439759857 no 2345 0.243315953617764 3678 45595301 SGTC_1294 1000-1494 117 µM -0.69651749619068 0.294632065284921 no 2346 0.243052402048368 3658 712797 YDL207W GLE1 SGTC_752 1896-0090 130 µM -0.699313883028325 0.293721390993327 no 2347 0.242177946386099 3670 772567 SGTC_1456 k015-0012 13 µM -0.700196114490651 0.293434353115166 no 2348 0.241902418905525 3736 2989616 SGTC_3132 9126706 49.47 µM -0.702172337963421 0.29279185215037 no 2349 0.241285847160888 3683 850858 SGTC_732 3970-1727 52.7 µM -0.703619901904379 0.292321641468863 no 2350 0.240834756957617 3678 1275699 SGTC_1683 st010134 710 nM -0.704011347358507 0.292194549001225 no 2351 0.240712853496738 3707 3818134 SGTC_1924 st058459 75.1 µM -0.705025571188195 0.291865375757381 no 2352 0.240397161446265 3645 688683 SGTC_2923 7992654 58.14 µM -0.705255360368826 0.291790820123915 no 2353 0.240325667540638 3714 2985126 SGTC_3031 9088762 49.47 µM -0.706129768142867 0.291507197649822 no 2354 0.240053720517156 3668 205253 SGTC_3325 9138760 55.175 µM -0.706159647071818 0.291497508407377 no 2355 0.240044430923543 3685 43844959 SGTC_2740 felodipine 17.08 µM -0.707200582210885 0.291160044170224 no 2356 0.239720918404387 3618 3333 L-type calcium channel blocker SGTC_2353 9059630 146.67 µM -0.709575965783529 0.290390644561036 no 2357 0.23898356404936 3722 4779114 SGTC_557 1315-0110 16.2 µM -0.710037192282676 0.290241361231626 no 2358 0.238840536392486 3700 6833801 SGTC_2593 nobiletin 86.24 µM -0.710511146884581 0.290087995709894 no 2359 0.238693610503263 3663 72344 An anti-infammatory. SGTC_821 1114-0266 29.2 µM -0.71056074408551 0.290071948898694 no 2360 0.238678238233814 3712 3123235 SGTC_489 paxilline 115 µM -0.710565197626543 0.29007050800846 no 2361 0.238676857919667 3669 105008 A toxic potassium channel blocker. SGTC_1633 st005664 67.9 µM -0.711060774076865 0.289910191103107 no 2362 0.238523288065054 3720 2063822 SGTC_3192 9110362 49.47 µM -0.71295283011677 0.289298501390651 no 2363 0.237937473136151 3755 16649480 SGTC_2532 xanthone 78.9 µM -0.713345068299235 0.28917176921925 no 2364 0.237816127858614 3613 7020 An insecticide. SGTC_999 SEC7.066 22.7 µM -0.71519819526061 0.288573377084533 no 2365 0.237243292034765 3702 740511 YDR170C SEC7 SGTC_172 1112-0046 2.638 µM -0.71526652554937 0.288551323747911 no 2366 0.237222184376264 3654 2802135 YIL048W NEO1 SGTC_1477 0139-0234 16 µM -0.715472274598145 0.288484923833405 no 2367 0.237158633423302 3700 620880 SGTC_1744 st037937 38.9 µM -0.715850629017774 0.288362839025395 no 2368 0.237041793224211 3742 1016152 SGTC_34 0469-0683 81.75 µM -0.716949250258301 0.288008481584521 no 2369 0.236702705699021 3693 3690923 SGTC_1201 1889-3372 45.9 µM -0.718604077682107 0.287475109606831 no 2370 0.236192450113361 3626 5392199 SGTC_1239 0337-0584 35.4 µM -0.718731206737626 0.287434153619757 no 2371 0.23615327574627 3749 914301 YML130C ERO1 SGTC_3060 1327-0027 12.5 µM -0.719097974454572 0.287316010939085 no 2372 0.23604027763619 3641 16000455 YPR107C YTH1 SGTC_1356 1502-0781 85.8 µM -0.719614527120321 0.287149658727366 no 2373 0.235881182557351 3693 567702 SGTC_1753 st043925 64 µM -0.719961451579544 0.287037959707805 no 2374 0.235774365123762 3727 670181 SGTC_1403 3909-7815 62.9 µM -0.720716869359364 0.286794809599821 no 2375 0.235541865606377 3656 6615483 SGTC_258 haloperidol 50.781 µM -0.722199874750044 0.286317751385882 no 2376 0.235085800166068 3734 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2669 eugenol 100 µM -0.722287925515025 0.286289438768738 no 2377 0.235058737453406 3674 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1992 st073643 23.3 µM -0.72280722964378 0.286122484198029 no 2378 0.234899162512323 3692 3161292 SGTC_2910 7948405 25.97 µM -0.723350240466577 0.285947957487732 no 2379 0.234732366883479 3652 2971328 SGTC_1010 4112-3296 15.2 µM -0.723874955876964 0.285779359115041 no 2380 0.234571253251395 3738 704384 SGTC_2043 5101342 149 µM -0.72538754706987 0.285293607260719 no 2381 0.234107155279096 3739 678451 SGTC_1209 2323-2347 50.3 µM -0.727051250383146 0.284759782099497 no 2382 0.233597280373278 3681 5412760 SGTC_997 3996-0078 137 µM -0.728824318830863 0.284191390701371 no 2383 0.233054566845802 3774 735687 SGTC_1699 st031318 29.054 µM -0.729587147331386 0.283947018277984 no 2384 0.232821290405137 3789 5340658 SGTC_2434 5670830 169.91 µM -0.730412134424091 0.28368284655917 no 2385 0.232569151673925 3746 1549830 SGTC_1366 1683-0113 21.9 µM -0.730544366496156 0.283640515058959 no 2386 0.232528752039749 3737 708623 SGTC_3000 9075062 71.4286 µM -0.730689559474976 0.283594037864683 no 2387 0.232484397075362 3705 17057871 SGTC_2558 carylophyllene oxide 100 µM -0.730709063579584 0.283587794754979 no 2388 0.232478439130135 3805 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2648 atorvastatin 78.68 µM -0.731612155894847 0.283298794179843 no 2389 0.23220266330379 3720 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2951 9072950 58.06 µM -0.732294026149646 0.283080680990835 no 2390 0.231994562376039 3745 16488155 SGTC_2075 5212009 200 µM -0.733711760943686 0.282627441349781 no 2391 0.231562214527803 3627 780898 SGTC_1035 k081-0041 55.2 µM -0.733999746130579 0.282535417190739 no 2392 0.231474446404349 3729 731709 SGTC_1484 3473-2379 286 µM -0.734856086880141 0.282261863126289 no 2393 0.231213572376393 3835 671917 SGTC_1340 1486-1359 257 µM -0.735265276571912 0.282131194402167 no 2394 0.231088975541577 3689 4309068 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.735855281890999 0.281942836144618 no 2395 0.230909386964791 3736 6312947 SGTC_892 0929-0076 29 µM -0.736422819006311 0.281761708006816 no 2396 0.230736710921222 3738 5751038 SGTC_2424 5537928 59.2 µM -0.739536169567192 0.280769088515221 no 2397 0.229790742495485 3813 5382802 SGTC_1867 st057372 64 µM -0.740900279796657 0.28033470708391 no 2398 0.229376952921091 3726 688837 SGTC_25 0118-0223 35.662 µM -0.742202790863428 0.279920244999407 no 2399 0.228982238955298 3760 5333628 SGTC_3315 9136395 68.55 µM -0.743443413143625 0.279525752579884 no 2400 0.22860663445488 3763 16876844 SGTC_1453 4237-0541 195 µM -0.744757755797847 0.279108113299974 no 2401 0.228209088502187 3682 739892 SGTC_2983 9022671 12.99 µM -0.746546255179502 0.278540295995691 no 2402 0.227668750343184 3753 6405161 SGTC_1515 3460-0031 42.1 µM -0.748187263342295 0.278019800062311 no 2403 0.227173606186302 3698 2876596 SGTC_2045 5106652 78.05 µM -0.748533436432412 0.277910061323177 no 2404 0.227069232377714 3728 673349 SGTC_129 0088-0017 176.636 µM -0.749835521055742 0.277497482886355 no 2405 0.226676886198726 3636 182446 SGTC_135 0933-0004 26.348 µM -0.749850988528528 0.277492583663789 no 2406 0.226672227816144 3752 21230617 YGL099W LSG1 SGTC_1844 rapamycin 4 nM -0.750307630874171 0.277347964186876 no 2407 0.226534723893009 3702 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_14 0354-0009 295 µM -0.752086701361649 0.276784881015527 no 2408 0.225999460404795 3817 1713507 SGTC_2484 5809818 12.04 µM -0.753892623710595 0.276213872465296 no 2409 0.225456850079733 3767 2870548 SGTC_3070 9117005 49.47 µM -0.755806923756644 0.275609228207146 no 2410 0.224882482465491 3785 8779016 SGTC_3256 9138902 49.47 µM -0.756934254558488 0.275253458100079 no 2411 0.224544625980297 3785 17228773 SGTC_2837 9008476 45.46 µM -0.757247762561824 0.275154559474379 no 2412 0.224450720104796 3754 2992805 SGTC_508 roscovitine 141 µM -0.757443581462653 0.275092795703262 no 2413 0.224392077264685 3826 160355 A CDKinase inhibitor. SGTC_3220 9131269 49.47 µM -0.758613867870447 0.274723814897891 no 2414 0.224041787237784 3814 17722206 SGTC_1674 st016616 23.6 µM -0.75924468551954 0.274525025025188 no 2415 0.223853099876963 3765 625830 SGTC_796 1234-0020 70.7 µM -0.759444459711895 0.274462084887045 no 2416 0.223793363147411 3709 46495034 SGTC_638 3970-0837 4.09 µM -0.761715937033568 0.273746942628951 no 2417 0.223114780718824 3759 4118451 YLR208W SEC13 SGTC_846 0335-0850 148 µM -0.76264624810847 0.273454313711577 no 2418 0.222837197587099 3787 6819598 SGTC_1539 benzyladenosine 56 µM -0.763228747757719 0.27327116758868 no 2419 0.222663493495016 3754 92208 A nucleotide analog. SGTC_2024 5144227 134 µM -0.764339592246938 0.272922070887762 no 2420 0.222332448559721 3825 3475211 SGTC_2372 9071633 200 µM -0.765459165501289 0.272570454969184 no 2421 0.221999086627264 3833 21321366 SGTC_1468 k284-1086 134 µM -0.767017613158175 0.272081379774032 no 2422 0.221535521770531 3772 15996457 SGTC_2101 5377231 179.231 µM -0.767422202364153 0.271954482147453 no 2423 0.22141526604557 3822 2844213 SGTC_2789 5281112 71.43 µM -0.768190170774294 0.271713693228887 no 2424 0.221187106102817 3810 765948 SGTC_672 1441-0018 53.7 µM -0.769004074590143 0.271458617601954 no 2425 0.220945445836007 3782 251141 SGTC_2150 5556613 200 µM -0.769484604847384 0.271308076523352 no 2426 0.220802840171174 3785 743190 SGTC_2479 5617353 43.85 µM -0.770428736367342 0.271012419138502 no 2427 0.220522806376039 3810 2731746 SGTC_1756 st041558 35.5 µM -0.771030057276596 0.27082419765868 no 2428 0.220344557935599 3837 3955792 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.77142295963965 0.270701249223728 no 2429 0.220228135246312 3752 4620898 SGTC_2914 7968218 45.32 µM -0.773074946584319 0.270184608606775 no 2430 0.21973901358757 3781 2977111 SGTC_160 3453-0671 289.699 µM -0.773751710618858 0.269973100635176 no 2431 0.21953881695686 3816 5322268 SGTC_1419 3993-2473 62.6 µM -0.773804016739027 0.269956756938158 no 2432 0.219523348409492 3850 704026 SGTC_1820 st053765 18.6 µM -0.776184903584114 0.269213343934745 no 2433 0.21881990918187 3800 3690829 SGTC_344 k064-0035 6.43 µM -0.777353147957715 0.268848944854698 no 2434 0.218475223218976 3790 5088750 SGTC_703 3875-0075 71.8 µM -0.777469135370157 0.268812779553354 no 2435 0.218441018654589 3827 2850814 SGTC_3273 9137859 49.47 µM -0.777883373757849 0.268683638451093 no 2436 0.218318885374363 3864 2377234 SGTC_564 3555-0129 330 µM -0.778925031344064 0.268359033762765 no 2437 0.218011938877852 3687 563260 SGTC_2566 crystal violet carbinol 226 nM -0.779499515799856 0.268180095491463 no 2438 0.217842761351099 3816 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1621 st003705 32.4 µM -0.779540938906901 0.268167195497961 no 2439 0.217830565760737 3834 24207032 SGTC_1607 st000305 50.6 µM -0.780458653636906 0.267881480683863 no 2440 0.217560477660578 3785 5457690 SGTC_3134 9127454 49.47 µM -0.780564247950525 0.26784861553559 no 2441 0.217529413122132 3892 24262820 SGTC_1120 ficusin 1.78878 µM -0.785731617007919 0.266242810563527 no 2442 0.216012368116994 3920 6199 A DNA cross-linker. SGTC_2592 piperlongumine 83.33 µM -0.786271024382268 0.266075466351549 no 2443 0.215854362038132 3834 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3186 9110464 49.47 µM -0.786648324433474 0.265958445524812 no 2444 0.215743881120218 3785 17018021 SGTC_1853 st056710 91.2 µM -0.788880347882092 0.265266710051715 no 2445 0.215090971382613 3910 269167 SGTC_2564 betulinic acid 100 µM -0.789925590195694 0.26494308906221 no 2446 0.214785612746346 3809 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1796 st049173 110.4 µM -0.790263611268413 0.264838476170048 no 2447 0.214686916692453 3757 94134 SGTC_1178 0988-0033 191 µM -0.790820070035015 0.264666305551145 no 2448 0.214524498192881 3867 5392207 SGTC_1199 1638-0010 4.46 µM -0.790935416344502 0.264630624055438 no 2449 0.214490839994803 3795 3111136 SGTC_545 4218-0007 221 µM -0.794786164360334 0.263440830748999 no 2450 0.213368950244892 3787 2840508 SGTC_1843 st055809 45.5 µM -0.794834568254747 0.263425892446272 no 2451 0.213354869898092 3870 16413835 SGTC_263 alizarin 107.927 µM -0.796294890083346 0.262975414565287 no 2452 0.212930327475587 3828 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_429 1112-0049 25.5 µM -0.796942339835203 0.262775816311775 no 2453 0.212742259769112 3793 2836170 SGTC_1817 st052116 64.4 µM -0.797893951220326 0.262482590666312 no 2454 0.212466016925728 3804 4361398 SGTC_1260 0700-1617 7.75 µM -0.798076526298584 0.262426351884877 no 2455 0.212413041257305 3854 2853078 SGTC_2799 7812892 81.82 µM -0.79934483396452 0.262035844187285 no 2456 0.212045244383814 3832 20205235 SGTC_1983 st071813 46.9 µM -0.801393529973651 0.261405687305564 no 2457 0.211451929792259 3903 11838595 SGTC_1919 st067113 52.3 µM -0.803554584751309 0.260741814545474 no 2458 0.210827130293913 3884 1268243 SGTC_2167 5876490 200 µM -0.804480462046733 0.260457652140617 no 2459 0.210559774300038 3999 686534 SGTC_3222 9128301 49.47 µM -0.805403354287975 0.260174564682761 no 2460 0.210293478373592 3870 4911358 SGTC_1827 berberine 7.24 µM -0.805611528103178 0.260110731488711 no 2461 0.210233438210209 3775 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2842 9000675 19.48 µM -0.807818737267756 0.25943442281185 no 2462 0.209597468511745 3865 2989072 SGTC_1049 3226-0134 66 µM -0.808824519775728 0.259126543562156 no 2463 0.20930804511488 3882 5702385 SGTC_849 0386-0493 241 µM -0.809486656010605 0.258923960749338 no 2464 0.20911763763524 3802 726119 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.81019139948962 0.258708432149077 no 2465 0.208915089875098 3864 2374 Ca(2+)-ATPase inhibitor. SGTC_3297 9117502 71.43 µM -0.810496625114262 0.258615115166437 no 2466 0.208827401966955 3862 7453720 SGTC_1971 st069429 63.5 µM -0.812069218062073 0.258134600870889 no 2467 0.208375957423814 3853 1246522 YGL099W LSG1 SGTC_1352 1496-0991 99 µM -0.813073940159168 0.257827845125494 no 2468 0.208087833283832 3848 3000039 SGTC_2327 6189656 200 µM -0.81360553794585 0.257665617427124 no 2469 0.207935482163271 3931 5349088 SGTC_1708 st033234 31.827 µM -0.813918948618057 0.257569998730517 no 2470 0.207845692365935 3944 674664 SGTC_932 2857-0803 154 µM -0.814115186979604 0.257510137604975 no 2471 0.207789483212081 3957 674898 SGTC_1811 st050069 61.5 µM -0.815465115128668 0.257098547483638 no 2472 0.20740306254264 3788 3877702 SGTC_2068 5226020 147 µM -0.815466883941898 0.257098008400903 no 2473 0.207402556493805 3901 1810509 SGTC_2122 5258151 111.688 µM -0.815740353368062 0.257014669959269 no 2474 0.207324327005666 3857 2173356 SGTC_303 1348-1668 34.2 µM -0.816452098507248 0.256797835081391 no 2475 0.207120804858244 3850 5380509 SGTC_1283 0922-0125 16.4 µM -0.817593493104909 0.256450305348798 no 2476 0.206794672127076 3869 3360884 SGTC_1955 wogonin 32.4 µM -0.817700952868424 0.256417598823193 no 2477 0.206763983121662 3946 5281703 A flavanone. SGTC_1923 st058458 19.1 µM -0.818400124209394 0.256204851653908 no 2478 0.206564375419036 3849 3534982 SGTC_709 3807-1509 243 µM -0.818432456525619 0.256195015650359 no 2479 0.20655514756902 3922 1886677 YPL242C IQG1 SGTC_3191 9110352 49.47 µM -0.818663110690108 0.256124852707005 no 2480 0.206489324478645 3810 17122424 SGTC_2780 5215298 71.43 µM -0.819754807030181 0.255792904407944 no 2481 0.206177949522698 3883 2834131 SGTC_1835 st008666 49.2 µM -0.820663547253903 0.255516758311878 no 2482 0.205918969952447 3788 690455 SGTC_2946 9065502 71.43 µM -0.820908481724681 0.25544235478764 no 2483 0.205849199728081 3694 16489101 SGTC_1731 st035964 63 µM -0.821551417979428 0.255247104492788 no 2484 0.205666124394326 3858 6739575 SGTC_1225 1216-0074 20.6 µM -0.824554059160917 0.254336280641322 no 2485 0.204812406320859 3871 4241466 SGTC_19 0279-0214 38.434 µM -0.824655978583997 0.254305394236418 no 2486 0.20478346537861 3914 3566274 YBR002C RER2 SGTC_2917 7979103 53.79 µM -0.825116266223935 0.254165929811074 no 2487 0.204652792837867 3922 2980565 SGTC_643 k048-0106 28.4 µM -0.825737831361239 0.253977662935185 no 2488 0.204476413453639 3895 6763920 SGTC_2346 9031566 143.75 µM -0.825850079698823 0.253943671655754 no 2489 0.204444570779166 3848 4771086 SGTC_2782 7736369 71.43 µM -0.825990231658543 0.253901233893863 no 2490 0.20440481653228 3927 2950836 YOL077C BRX1 SGTC_1956 st077085 54 µM -0.826208168434015 0.253835250424188 no 2491 0.204343007684513 3906 24208685 SGTC_2959 9079155 11 µM -0.828046703128647 0.253278966274322 no 2492 0.203822025578071 3898 16189457 SGTC_1183 1254-0324 198 µM -0.829368684689686 0.252879371735343 no 2493 0.20344790793727 3946 5799357 SGTC_3300 9124615 50.48 µM -0.829457251504151 0.252852612565221 no 2494 0.203422858389764 3926 24824903 SGTC_2521 angolensin 13.4 µM -0.8294926953082 0.252841904154852 no 2495 0.203412834256031 3951 821428 A flavenoid. SGTC_2054 5233173 129 µM -0.829656981307015 0.252792272592192 no 2496 0.203366375123099 3912 6889 SGTC_2028 5153890 36.43 µM -0.829824717463313 0.252741604013432 no 2497 0.203318946838392 3845 2830968 YPR165W RHO1 SGTC_1967 st070177 51.4 µM -0.831806099376935 0.252143486769765 no 2498 0.202759200277692 3929 5729214 SGTC_1206 3978-0017 132 µM -0.832481254644401 0.251939849181624 no 2499 0.20256867733876 3982 3873677 SGTC_2970 9090938 41.86 µM -0.833525673820484 0.25162500678151 no 2500 0.202274162241833 3920 17217104 SGTC_2291 7917025 104.35 µM -0.834035683359065 0.251471338869223 no 2501 0.202130438099778 3831 2964612 SGTC_767 0929-0023 86 µM -0.834304305926898 0.251390421759587 no 2502 0.202054763014887 3914 1204563 SGTC_2727 riluzole 51.77 µM -0.834408890053529 0.251358921631583 no 2503 0.202025304653514 3884 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2821 7996764 71.43 µM -0.834755958092724 0.251254401718614 no 2504 0.20192756392034 3914 2987135 SGTC_130 0136-0219 337.655 µM -0.837473476439594 0.250436813225815 no 2505 0.201163239881129 3775 234244 SGTC_312 4092-0653 6.84 µM -0.837478505571487 0.250435301476946 no 2506 0.201161827007263 3852 1148278 SGTC_504 lovastatin 124 µM -0.839079102011271 0.249954410609101 no 2507 0.20071246115475 3908 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_864 0469-0573 172 µM -0.841180129735641 0.249323912367687 no 2508 0.200123515198995 3877 689425 SGTC_1321 1326-2144 215 µM -0.843461198235149 0.248640344086898 no 2509 0.199485278889623 3897 3513030 SGTC_713 1488-1073 324 µM -0.843546653094475 0.248614755224128 no 2510 0.199461392703489 3838 3312542 SGTC_163 TUB2.036 7.546 µM -0.845278370478384 0.248096506896176 no 2511 0.198977717270654 3908 15992207 YJR013W GPI14 SGTC_349 k015-0014 24 µM -0.845300345183441 0.248089934265701 no 2512 0.198971584194526 3895 2196908 SGTC_1640 st009078 66.4 µM -0.846025146624745 0.247873198347859 no 2513 0.198769358077224 3855 690618 SGTC_1235 benzylparaben 21.5 µM -0.849701588335009 0.246775397623368 no 2514 0.197745507575692 3918 7180 SGTC_1125 tnp00248 1.32998 µM -0.85202637862464 0.246082551398218 no 2515 0.197099725720438 4008 24207736 SGTC_561 1550-0330 72.9 µM -0.852938599678688 0.245810971801073 no 2516 0.196846677363478 3856 6812934 SGTC_1519 esterone 74 µM -0.853287450226411 0.245707157181737 no 2517 0.196749958916508 3894 698 A steroid. SGTC_2279 7948423 32.93 µM -0.853545442327008 0.245630396322007 no 2518 0.196678449394393 3833 1247112 SGTC_2286 7945697 125 µM -0.855339478466401 0.245096969838589 no 2519 0.196181619025116 3944 1245733 SGTC_441 propafenone 146 µM -0.85619062032247 0.24484411520529 no 2520 0.195946174963041 3892 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1130 3454-2858 15.9 µM -0.856222973328506 0.244834506643261 no 2521 0.195937228812199 3963 715628 YIL048W NEO1 SGTC_1510 1123-0200 71.5 µM -0.8588973392588 0.244040945407863 no 2522 0.195198578755194 3981 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_996 3970-0799 1.8 µM -0.859581690301842 0.243838101947046 no 2523 0.195009835774965 3952 6615648 YGL040C HEM2 SGTC_533 1222-0222 6.71 µM -0.860526083254883 0.243558330866885 no 2524 0.194749555909852 3994 3982874 SGTC_488 nitrendipine 139 µM -0.860651693005832 0.243521132755021 no 2525 0.194714953105293 3957 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1629 st005085 44.9 µM -0.863075351530842 0.242803990960213 no 2526 0.194048019497057 3903 24207091 SGTC_2049 5262831 67.185 µM -0.863473568354189 0.242686271105813 no 2527 0.193938572902676 3959 763417 SGTC_847 0342-0274 5.54 µM -0.865062296144741 0.242216923094026 no 2528 0.193502298785883 3920 18097 SGTC_1569 carminic acid 40.6 µM -0.865589472342409 0.242061291485418 no 2529 0.193357665445265 3995 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_851 0394-0702 453 µM -0.868365964929485 0.241242518059453 no 2530 0.192597010406241 3886 762646 SGTC_759 3486-0358 89.3 µM -0.868456522879771 0.241215838354659 no 2531 0.192572231756053 3891 875103 SGTC_2032 5185112 25.99 µM -0.868580448832737 0.241179330544304 no 2532 0.192538326043223 3822 5718189 SGTC_2021 4019055 173 µM -0.86891752372865 0.241080045585489 no 2533 0.192446121978661 3854 44827708 YER133W GLC7 SGTC_2974 9094440 9.66 µM -0.868956345358397 0.24106861215375 no 2534 0.192435504375199 3983 25236134 SGTC_3286 9117135 37.221 µM -0.869205814451304 0.240995147573634 no 2535 0.192367283845889 3905 3438150 SGTC_2385 9074692 200 µM -0.870494814182934 0.240615752224564 no 2536 0.192015025987368 3954 17046906 SGTC_1760 st045453 10.4495 µM -0.87090143659977 0.24049613726669 no 2537 0.191903986166401 3991 3323419 YIL048W NEO1 SGTC_3342 9147791 14.508 µM -0.872044611201052 0.24016002640612 no 2538 0.191592020465998 3852 1838168 SGTC_3061 glucosamine 200 µM -0.873397507365026 0.239762585210143 no 2539 0.191223224591566 3811 91431 and experimental redox chemotherapeutic SGTC_3306 9127676 59.7925 µM -0.873882301139456 0.239620254411988 no 2540 0.191091177090228 3939 41905287 SGTC_453 enantio-paf c16 10 µM -0.874163067249126 0.239537845271135 no 2541 0.191014727955621 3824 13871343 A lipid and platelet activating factor SGTC_1153 4055-0057 267 µM -0.875842166580235 0.239045327096304 no 2542 0.190557921648394 3979 882706 SGTC_830 4076-0286 57.8 µM -0.876565556928323 0.238833310936665 no 2543 0.190361327029784 4004 6866659 SGTC_1654 st012436 41.8 µM -0.876904811283387 0.238733915404807 no 2544 0.190269171350773 3880 4323132 SGTC_813 k007-0158 173 µM -0.876972369801141 0.238714124655275 no 2545 0.190250822903146 3945 6523916 SGTC_2409 alverine citrate 63.97 µM -0.87699235987399 0.238708268888884 no 2546 0.19024539393968 4136 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_416 estradiol valerate 100 µM -0.882412376753182 0.237123466233383 no 2547 0.188776922546313 3967 13791 A steroid. SGTC_266 formosanin C 406 nM -0.883182194169298 0.236898842873665 no 2548 0.188568920211949 3858 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2587 piperic acid 92.2 µM -0.883287499631847 0.236868125118449 no 2549 0.188540477986198 3956 5370536 SGTC_887 0885-0007 9.62 µM -0.885433590264642 0.236242584707087 no 2550 0.18796141121419 4037 5719458 SGTC_128 0906-2981 13.371 µM -0.88642262017992 0.235954609758626 no 2551 0.187694917213096 3869 6740226 SGTC_472 calcifediol 10 µM -0.886685188245108 0.235878190562767 no 2552 0.187624207503544 3978 5283731 A vitamin D metabolite. SGTC_1192 1488-0095 21.4 µM -0.887433562329988 0.235660454695596 no 2553 0.187422760313958 4000 915875 SGTC_679 0422-0091 41.4 µM -0.887664850126344 0.235593185046412 no 2554 0.187360529363217 3929 627384 YHR062C RPP1 SGTC_2675 theaflavin digallate 100 µM -0.889001396018918 0.235204660567985 no 2555 0.187001164769257 3910 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1240 0356-0016 42.1 µM -0.890709675150584 0.234708591379683 no 2556 0.186542471470904 3943 4305613 SGTC_1922 5578187 25 µM -0.8908835798868 0.234658123441938 no 2557 0.186495815085028 3976 1350412 SGTC_704 1310-0270 142 µM -0.890948558445277 0.234639267911703 no 2558 0.186478384035153 3962 5718033 SGTC_1029 k015-0030 64.7 µM -0.891018021753389 0.234619111919866 no 2559 0.186459751029093 4026 2208316 SGTC_2428 5615643 7.78 µM -0.891907117671532 0.234361209796569 no 2560 0.186221359636999 4006 2253075 SGTC_1706 st031321 9.9705 µM -0.893097233653996 0.234016235777331 no 2561 0.18590255214935 3984 6103185 SGTC_2732 terfenadine 20 µM -0.89577113476267 0.233242189947687 no 2562 0.185187504683203 3967 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3253 9135987 49.47 µM -0.895803078426314 0.233232951434349 no 2563 0.18517897273238 3955 4182430 SGTC_3110 9122132 49.47 µM -0.897178419717333 0.2328353779387 no 2564 0.184811859325575 4071 918317 SGTC_2640 pentamidine 10.38 µM -0.900229197917314 0.231954826964384 no 2565 0.183999145451814 3966 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1234 0326-0494 15.5 µM -0.900482362559062 0.231881839071166 no 2566 0.183931803645594 4050 1547813 SGTC_1548 st061468 90.8 µM -0.900780457706958 0.23179591402021 no 2567 0.183852530001106 3955 390799 SGTC_1031 k035-0009 16 µM -0.900859238885114 0.231773208540619 no 2568 0.183831582960435 4048 5180959 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.901839555381418 0.231490775731222 no 2569 0.183571052035902 4014 4174840 SGTC_1908 st060353 56.5 µM -0.90337378900635 0.231049142735704 no 2570 0.18316377309284 4035 4227716 SGTC_151 3013-0144 2.285 µM -0.903528578223075 0.231004612402316 no 2571 0.183122713941387 3895 906558 YHR107C CDC12 SGTC_1794 st048918 76.9 µM -0.905026506546424 0.230573930443835 no 2572 0.182725672434083 3864 672303 SGTC_611 3453-1652 23.7 µM -0.905366508746958 0.230476236075591 no 2573 0.182635626204819 3969 1560575 SGTC_254 nsc-64875 3.808 µM -0.905741396302258 0.230368544766085 no 2574 0.182536373059122 4004 56993 SGTC_2119 5528445 120.635 µM -0.906289727958693 0.230211080073075 no 2575 0.182391260504294 3993 791935 SGTC_3344 9148862 3.898 µM -0.908009798805923 0.229717517256147 no 2576 0.181936522309372 4034 4905352 SGTC_2878 9043973 25.97 µM -0.908427112824318 0.229597861185232 no 2577 0.181826303224696 4057 6465167 SGTC_1733 st037357 54.9 µM -0.909018362341705 0.229428392540797 no 2578 0.181670216609168 3902 1272339 YGL099W LSG1 SGTC_3345 9148410 3.559 µM -0.909397065007085 0.229319882610326 no 2579 0.181570285253639 3951 4903596 SGTC_2183 6420625 130.508 µM -0.909727653819499 0.229225182299438 no 2580 0.181483078221824 3962 2897619 SGTC_1564 D-Arginine 115 µM -0.909732396518973 0.229223823867624 no 2581 0.181481827321451 3996 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2979 9012552 45.46 µM -0.909736861768104 0.229222544908891 no 2582 0.181480649604322 4011 17100905 SGTC_2696 st077691 74.316 µM -0.910100960498014 0.229118271417328 no 2583 0.181384634038692 4032 757133 SGTC_2018 5133068 143 µM -0.910407465004063 0.229030512847467 no 2584 0.181303831162841 3960 785362 SGTC_2588 indole-3-carbinol 100 µM -0.910940895361472 0.22887782569911 no 2585 0.181163258257038 4047 3712 Induces cell cycle arrest. SGTC_3170 9103054 49.47 µM -0.91108117386258 0.228837682384885 no 2586 0.18112630252909 4004 16432970 SGTC_495 decylubiquinone 155 µM -0.911621741897902 0.228683025704066 no 2587 0.180983936525906 4034 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2393 9031399 185.94 µM -0.911755638094816 0.228644727032204 no 2588 0.180948683964776 4038 1526623 YDL150W RPC53 SGTC_3080 9117754 49.47 µM -0.913949627866546 0.228017687819692 no 2589 0.180371657317736 4001 9550191 SGTC_1941 st076221 61.8 µM -0.914346175346329 0.227904458399067 no 2590 0.180267487330875 3909 2828568 SGTC_1748 st037455 53.6035 µM -0.914508297546509 0.22785817544341 no 2591 0.180224909945431 4033 580690 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.915721598653773 0.227511967869517 no 2592 0.179906466821472 4038 521171 SGTC_2030 5175110 200 µM -0.918095583388242 0.226835424430338 no 2593 0.179284413451981 4044 2831986 SGTC_825 1988-2224 89.6 µM -0.919013295622146 0.22657419723956 no 2594 0.17904430896214 3968 1180859 SGTC_1071 trifluoperazine 6.31 µM -0.919252191045573 0.226506223420359 no 2595 0.1789818390607 4093 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3264 9137442 49.47 µM -0.919406203160163 0.226462407875043 no 2596 0.178941572971898 3987 17015726 SGTC_2097 5376186 200 µM -0.919442732860247 0.226452016091387 no 2597 0.178932023208097 3959 742755 SGTC_215 1287-0124 461.5 µM -0.920113928530765 0.226261125686996 no 2598 0.178756613210025 4004 5560863 SGTC_3101 9120531 49.47 µM -0.920219770534985 0.226231032149661 no 2599 0.178728962389382 3994 24824904 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.921904973272596 0.225752191476915 no 2600 0.178289072406392 4044 5282362 SGTC_2038 4100038 30.985 µM -0.925421301223996 0.224754895594988 no 2601 0.177373401411708 3998 3596803 SGTC_1333 1482-0047 286 µM -0.926429277732703 0.224469476154095 no 2602 0.17711146735414 3996 3811116 SGTC_1214 0358-0031 63.7 µM -0.927398187423176 0.224195312892529 no 2603 0.176859915704119 4154 4301366 SGTC_2152 5568786 200 µM -0.927643181339141 0.224126019399951 no 2604 0.176796345330774 3978 5399883 SGTC_870 0573-2213 57.6 µM -0.927844996905297 0.224068947506753 no 2605 0.176743989612623 3994 3916321 SGTC_1732 st034308 51.822 µM -0.928662997956443 0.223837707646874 no 2606 0.176531881238513 3871 830119 SGTC_2415 st077333 57.7 µM -0.928986104431317 0.223746406397929 no 2607 0.176448143826489 4033 2766255 SGTC_724 3910-0327 137 µM -0.929821063570261 0.223510567344863 no 2608 0.176231869260325 4057 2885483 SGTC_2687 chenodiol 100 µM -0.930409453924753 0.223344458042204 no 2609 0.176079562771674 4094 5702181 A cholesterol synthesis inhibitor. SGTC_2263 7948595 193.29 µM -0.931232161626788 0.223112316108881 no 2610 0.175866742343278 3982 2971371 SGTC_753 1322-0200 289 µM -0.932151328128509 0.22285311913745 no 2611 0.175629162442453 4093 5403907 SGTC_510 ag-490 170 µM -0.934354042945764 0.222232671384241 no 2612 0.175060647816799 4129 5328779 SGTC_1520 flindersine 88 µM -0.937745626699587 0.221279279978005 no 2613 0.174187574935476 4146 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3339 9145883 14.936 µM -0.938336486270106 0.22111342595565 no 2614 0.174035757407014 3939 2030670 SGTC_1425 4048-4433 7.33 µM -0.940509916010235 0.220503957580554 no 2615 0.17347803286261 4055 23734946 SGTC_2994 9053520 71.4286 µM -0.941047002475535 0.220353497449307 no 2616 0.173340386403453 4085 4647384 SGTC_1880 MG-132 525 µM -0.941218854788095 0.220305366940589 no 2617 0.173296358159675 3980 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3234 9132280 49.47 µM -0.942031494202881 0.220077853469456 no 2618 0.173088257903178 4055 17612295 SGTC_338 4055-0136 114 µM -0.94249599752663 0.219947867713038 no 2619 0.172969379672669 3960 2900563 SGTC_2277 7947813 106.88 µM -0.943777155124191 0.219589579334131 no 2620 0.172641768492222 4099 1246798 SGTC_190 3970-0790 3.722 µM -0.945214482485874 0.219188015800899 no 2621 0.172274693578842 3921 2832352 SGTC_3209 9113616 49.47 µM -0.945241586607455 0.219180447452217 no 2622 0.172267776322198 4084 16649353 SGTC_2900 5328528 85.29 µM -0.946808882848088 0.218743063158916 no 2623 0.171868087277031 4034 795359 SGTC_1411 3909-8223 150 µM -0.94847625609261 0.218278302364544 no 2624 0.171443527422932 4044 X1411 SGTC_1003 4049-0218 100 µM -0.948576103112648 0.218250489241696 no 2625 0.171418124868806 4064 295161 SGTC_1603 st002045 67.8 µM -0.950897131899059 0.217604525260069 no 2626 0.17082829895485 4023 5887985 SGTC_2120 5538279 151.968 µM -0.951373876546656 0.217471979492192 no 2627 0.170707308324224 4007 2058197 SGTC_659 k018-0002 107 µM -0.951917534346657 0.217320887250946 no 2628 0.170569403096157 4051 6797879 YHR007C ERG11 SGTC_1985 st071382 65.5 µM -0.953603101820431 0.216852823373208 no 2629 0.170142292533012 4023 6123237 SGTC_1309 pyrazolanthrone 13.4 µM -0.953930133404558 0.216762077791361 no 2630 0.170059504556492 4026 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3282 9108498 15.4605 µM -0.955563323638454 0.216309224661209 no 2631 0.169646449299226 4033 16459645 SGTC_2969 9091408 28.7 µM -0.95846991217724 0.215504638130485 no 2632 0.168912928185021 3989 4286311 SGTC_1764 st044502 93.5 µM -0.958929406882578 0.21537760231089 no 2633 0.168797154607401 4091 8407 SGTC_2717 st081029 62.2815 µM -0.96152672753375 0.214660342278643 no 2634 0.168143696681533 4017 5292846 SGTC_548 1436-0017 110 µM -0.963202797639171 0.214198226995649 no 2635 0.167722880717016 4129 9677137 SGTC_998 3996-0085 177 µM -0.96343792355603 0.214133445914084 no 2636 0.167663901236526 4071 715391 SGTC_1660 st012960 28.1 µM -0.964150323187034 0.213937237639907 no 2637 0.167485282969423 4044 24207266 SGTC_2448 5185112 27.17 µM -0.96449347885804 0.213842763468876 no 2638 0.167399288129153 4075 5718189 SGTC_1282 0886-0010 32.4 µM -0.964529955607162 0.213832722485484 no 2639 0.167390148725955 4104 2836211 YNL267W PIK1 SGTC_1728 st035614 33.7865 µM -0.965287051755612 0.213624378027917 no 2640 0.167200527693798 4026 15945546 SGTC_1502 4534-4282 27.7 µM -0.965923215877898 0.213449404197367 no 2641 0.167041302197632 3991 3278949 SGTC_1374 2889-5571 141 µM -0.968143549932245 0.212839367090286 no 2642 0.166486341325762 4112 2853281 SGTC_2858 9025781 8.96 µM -0.968676761440151 0.212693018833962 no 2643 0.166353245345769 3984 4894980 YPL153C RAD53 SGTC_2661 dactinomycin 12.96 µM -0.970044973414885 0.212317760540225 no 2644 0.166012037689397 4028 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.97365056512805 0.211330713369931 no 2645 0.165115035263549 4134 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2735 sertaconazole 140 nM -0.974281162463654 0.211158361053954 no 2646 0.164958477625574 4179 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2401 5128683 200 µM -0.974642869367501 0.211059537970039 no 2647 0.164868720485236 4051 708373 SGTC_1057 3448-5381 134 µM -0.97470885620424 0.211041512422613 no 2648 0.16485234934199 4065 5497911 SGTC_1837 st055472 66.5 µM -0.975182780559587 0.210912077574777 no 2649 0.164734801018471 4162 676091 SGTC_3354 9151612 71.43 µM -0.976496381740138 0.210553559566821 no 2650 0.164409270031005 4093 27261949 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.984335715744515 0.208421436637797 no 2651 0.162475237078333 4121 5393153 SGTC_543 3844-1095 191 µM -0.987362138583668 0.207601736401424 no 2652 0.161732569141685 4076 4230703 SGTC_2131 toluylene red 5.2905 µM -0.988291376686685 0.207350436973745 no 2653 0.161504983726181 4067 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_553 k007-0256 45.7 µM -0.989086669582307 0.207135504052355 no 2654 0.161310369564004 4130 6287000 SGTC_486 niguldipine 82 µM -0.991170466626793 0.206572970163052 no 2655 0.160801174494809 4124 1236 A calcium channel blocker. SGTC_2883 9059145 45.46 µM -0.99150900077887 0.206481666296341 no 2656 0.160718549749757 4066 16476510 SGTC_2217 6934799 96.0675 µM -0.991642595024123 0.206445642032418 no 2657 0.160685951540014 4057 675606 SGTC_1808 st050063 61.5 µM -0.991929464510919 0.206368299023324 no 2658 0.16061596737063 4055 4011993 SGTC_1011 4112-3381 17.4 µM -0.992714372885704 0.206156767311109 no 2659 0.160424584292864 4161 2877139 SGTC_3104 9120930 49.47 µM -0.994454292045265 0.20568832008225 no 2660 0.160000873774043 4114 17014836 SGTC_256 clotrimazole 625 nM -0.995331500225203 0.205452384633602 no 2661 0.159787531057475 4022 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3066 9117245 49.47 µM -0.998531322973263 0.204593118035284 no 2662 0.159010891742511 4148 17176980 SGTC_748 act1.228 77.9 µM -0.999563877299662 0.204316297335342 no 2663 0.158760805869016 4024 4421505 YNR035C ARC35 SGTC_2703 st077852 53.4 µM -0.999602516027309 0.204305942889039 no 2664 0.158751452531215 4138 6281836 SGTC_1386 3228-0095 33.8 µM -1.00202307375608 0.203657902368004 no 2665 0.158166224480814 4108 870181 SGTC_712 r015-0009 80.6 µM -1.00305934403616 0.203380843418193 no 2666 0.157916114609604 4126 6813872 YLR060W FRS1 SGTC_397 arbidol 50 µM -1.00545909194654 0.20274010682593 no 2667 0.157337919047689 4138 131410 A RNA synthesis inhibitor. SGTC_2285 7945142 200 µM -1.00712970086054 0.202294764491034 no 2668 0.15693622500128 4143 2970608 SGTC_180 1486-1293 102.781 µM -1.00904510592306 0.20178488632097 no 2669 0.156476501252487 3980 4140536 SGTC_3178 9107506 49.47 µM -1.00908506051697 0.201774258663893 no 2670 0.156466921047847 4119 8897194 SGTC_2849 9019321 12.99 µM -1.00960513246134 0.201635953554737 no 2671 0.156342254835849 4121 16489627 SGTC_212 3807-4682 38.772 µM -1.01129558324931 0.201186796689629 no 2672 0.155937489687923 4164 3125501 YBL034C STU1 SGTC_201 4262-0159 12.803 µM -1.01146925948286 0.201140684504185 no 2673 0.155895943444556 4133 1341029 SGTC_2374 9071832 200 µM -1.01204262927311 0.200988496051718 no 2674 0.155758835670517 4003 17381698 SGTC_275 trichlorophene 5.69 µM -1.01293800413112 0.200750976617621 no 2675 0.155544887110305 4152 62616 SGTC_33 0986-0033 35.816 µM -1.01390485099639 0.200494686814112 no 2676 0.155314078210354 4060 2848082 SGTC_606 k015-0008 38.6 µM -1.01398564584432 0.200473278780087 no 2677 0.155294800834289 4195 1970475 SGTC_1185 1319-0113 81.3 µM -1.01556242485446 0.200055757995051 no 2678 0.154918902867163 4172 4672763 SGTC_50 0929-0078 56.389 µM -1.01586799141954 0.199974906474055 no 2679 0.154846126562361 3968 1377751 SGTC_1578 josamycin 24.2 µM -1.01698520569062 0.199679463945794 no 2680 0.154580233671605 4117 5282165 A P450 substrate. SGTC_1052 3253-3998 198 µM -1.01718600541095 0.199626391176245 no 2681 0.154532476086849 4041 5450317 SGTC_3266 9136860 49.47 µM -1.01783007687444 0.199456215874013 no 2682 0.154379357936389 3950 4871271 YPR165W RHO1 SGTC_1927 st060202 13.8 µM -1.01822494005975 0.19935192908985 no 2683 0.154285534863852 3983 688887 SGTC_2872 9044037 25.97 µM -1.01862536361802 0.199246207298355 no 2684 0.154190429111546 4105 6465195 SGTC_1077 5-fluorocytosine 377 nM -1.01870958017524 0.199223976328425 no 2685 0.15417043153085 4147 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_628 1636-0253 16 µM -1.01876097665131 0.1992104097362 no 2686 0.154158228061376 4106 4456143 SGTC_1043 0916-0009 19.3 µM -1.01892605446715 0.199166839629173 no 2687 0.154119036659373 4146 3101130 SGTC_764 1951-2361 146 µM -1.02023855658819 0.198820626342923 no 2688 0.153807667865739 4097 5438930 SGTC_2557 derrustone 83.84 µM -1.02080846122169 0.198670409294222 no 2689 0.153672597430023 4111 629853 An antioxidant. SGTC_1868 st057644 42.7 µM -1.02214096141212 0.198319452378229 no 2690 0.153357094339985 4118 688665 SGTC_2699 st077704 54.6 µM -1.02224306084636 0.198292576639936 no 2691 0.153332937431691 4124 645852 SGTC_3240 9133527 49.47 µM -1.02249304588488 0.198226782103774 no 2692 0.153273801168962 4045 17617455 SGTC_3088 9117578 49.47 µM -1.02358197036838 0.197940337583551 no 2693 0.153016382357962 4155 678341 SGTC_3038 9091290 49.47 µM -1.02382737190629 0.197875818585507 no 2694 0.152958409691055 4150 25236843 SGTC_2718 lomofungin 53.02 µM -1.02565727395733 0.19739511614994 no 2695 0.152526580214567 4100 5351222 A RNA synthesis inhibitor. SGTC_677 0929-0063 136 µM -1.02670405926642 0.197120450815552 no 2696 0.152279918646975 4084 1539583 SGTC_1684 st024538 14.6195 µM -1.03041903745249 0.196147548366574 no 2697 0.151406670155664 4087 6732859 SGTC_183 3914-0051 30.55 µM -1.03134908348875 0.19590443844055 no 2698 0.151188574319358 4157 1596232 SGTC_1266 0828-0227 32.9 µM -1.0314491861166 0.195878282958244 no 2699 0.151165112712899 4116 3913820 SGTC_2720 fluspirilene 36.88 µM -1.0324171196772 0.195625484140458 no 2700 0.150938377720195 4133 3396 An atypical antipsychotic. SGTC_761 k216-0224 480 µM -1.03408341078961 0.195190756961079 no 2701 0.150548585447106 4166 1340404 SGTC_1999 st074831 12.5 µM -1.03465879739674 0.195040777890661 no 2702 0.15041414224074 4083 17112523 SGTC_2622 2-methoxyxanthone 59.94 µM -1.03559794257296 0.194796132814531 no 2703 0.150194876116171 4132 71034 A hepatoprotective. SGTC_1381 2324-0066 62.1 µM -1.04072798193319 0.193463067216689 no 2704 0.149000906323114 4191 10885928 SGTC_757 1066-0008 322 µM -1.04305207707003 0.192860975994562 no 2705 0.148462087099178 4162 6842497 SGTC_2313 7726885 200 µM -1.04326869869662 0.192804915332642 no 2706 0.148411931916887 4174 726423 SGTC_2545 solidagenone 89.61 µM -1.04460423108705 0.192459505749282 no 2707 0.148102961637897 3964 6708572 An anti ulcer agent SGTC_565 1418-0001 44.5 µM -1.04494680142055 0.192370967572289 no 2708 0.148023778725938 4214 2862145 SGTC_1757 st041620 31.8375 µM -1.04661626394236 0.191939847281948 no 2709 0.147638298853138 4203 5289815 SGTC_798 1287-0182 476 µM -1.04736017378442 0.191747931387484 no 2710 0.147466746385896 4175 1649755 SGTC_2935 9038016 29.96 µM -1.04796965576538 0.191590783164151 no 2711 0.147326293799798 4129 6463195 SGTC_2 0422-0095 29 µM -1.04996873811712 0.191075895758611 no 2712 0.146866243042404 4042 6790840 SGTC_1491 4138-0063 26.5 µM -1.05135369305527 0.190719682227474 no 2713 0.146548087667877 4105 23883227 SGTC_1540 guanosine 70.6 µM -1.05212191162502 0.190522270525704 no 2714 0.146371810150644 4015 6802 Guanosine is a purine nucleoside SGTC_2683 piperine 63.03 µM -1.0525467936675 0.190413141064872 no 2715 0.146274376732293 4126 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_108 0509-0257 621.132 µM -1.05385105782726 0.190078385250197 no 2716 0.145975556613068 4102 536624 SGTC_815 1582-0027 36.9 µM -1.05458569561723 0.189889990548555 no 2717 0.145807424366552 4180 3128206 SGTC_1136 pergolide 1.05886 µM -1.05593127481986 0.189545220386979 no 2718 0.145499807191017 4113 47811 A dopamine receptor agonist. SGTC_2458 5808907 16.39 µM -1.05903524759313 0.188751377176808 no 2719 0.144791863753367 4294 2731747 SGTC_133 0724-0033 378.92 µM -1.05932217864542 0.188678097969463 no 2720 0.144726538829561 3986 280309 SGTC_1184 1269-1718 139 µM -1.06077789007533 0.188306594652449 no 2721 0.144395426243926 4210 5403821 SGTC_3184 9108758 49.47 µM -1.06118339515049 0.188203188568675 no 2722 0.144303282029768 4172 902885 SGTC_2311 7694451 200 µM -1.06325560757859 0.187675309926131 no 2723 0.143833025442284 4142 2163142 SGTC_777 1315-0167 517 µM -1.06932699122881 0.186133949248207 no 2724 0.142461176205357 4183 4221767 SGTC_2324 6149169 200 µM -1.06936109956534 0.186125312284114 no 2725 0.142453494397246 4071 2888231 SGTC_3239 9133757 49.47 µM -1.07037018798061 0.185869901798505 no 2726 0.142226356373184 4192 17036923 SGTC_3212 9128307 49.47 µM -1.07065758643277 0.185797198130463 no 2727 0.142161710060799 4108 27243542 SGTC_3114 9122766 49.47 µM -1.07167721257835 0.185539403923679 no 2728 0.141932519685941 4166 17176985 SGTC_877 0771-0151 33.1 µM -1.07336606430887 0.18511289663819 no 2729 0.141553452189619 4185 6166523 SGTC_2265 7929201 200 µM -1.07466109462954 0.184786258995739 no 2730 0.141263244081279 4128 1265108 SGTC_483 fpl-64176 144 µM -1.07485872949413 0.184736442280895 no 2731 0.141218990856607 4253 3423 SGTC_3081 9117243 49.47 µM -1.0778039875809 0.183995037145547 no 2732 0.140560619821718 4154 45595589 SGTC_2322 7413319 38.22 µM -1.07921129911818 0.183641431898688 no 2733 0.140246771893356 4194 1840400 SGTC_1317 1273-0028 910 nM -1.0807666284561 0.183251128219343 no 2734 0.139900468241164 4168 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3055 9094636 49.47 µM -1.08280162944933 0.182741234748054 no 2735 0.139448241076036 4205 25236176 SGTC_812 4251-0442 148 µM -1.08470737962225 0.182264530571497 no 2736 0.13902563918423 4208 5723007 SGTC_714 4296-0578 26.1 µM -1.08697189672889 0.181699095830057 no 2737 0.13852461495464 4215 1589775 SGTC_1312 1218-2183 165 µM -1.08765464567723 0.181528833558921 no 2738 0.138373798492426 4225 6744073 SGTC_1884 5633444 25 µM -1.08936888808703 0.181101780267417 no 2739 0.137995622727336 4171 5724239 SGTC_2551 apiole 73.87 µM -1.08995552065546 0.180955782605694 no 2740 0.137866368879254 4079 10659 A possible DNA adduct former. SGTC_541 4513-1321 94 µM -1.09157404630965 0.180553356072972 no 2741 0.137510184503965 4151 747515 SGTC_1297 1068-0111 14.1 µM -1.09281444800861 0.180245325649681 no 2742 0.13723763836984 4158 767057 SGTC_75 0159-0059 199.013 µM -1.0930975921747 0.180175058385276 no 2743 0.137175476534899 4285 5377270 SGTC_2874 9043904 71.43 µM -1.09359937342256 0.180050574680277 no 2744 0.137065362084848 4129 4463428 SGTC_2621 lithochol-11-enic acid 100 µM -1.09391242487789 0.179972939104351 no 2745 0.136996694444819 4146 6708711 SGTC_1998 st075797 76.8 µM -1.09602774247557 0.179448899404255 no 2746 0.136533316968103 4177 24208315 SGTC_760 0568-0725 82.9 µM -1.09671051098391 0.179279958246972 no 2747 0.136383980085902 4221 3916171 SGTC_1483 3453-0561 55.9 µM -1.09827337025301 0.178893628057567 no 2748 0.13604256824431 4196 4546991 SGTC_2297 7971671 152.32 µM -1.09869153604974 0.178790348696258 no 2749 0.135951317822488 4201 909016 SGTC_2818 7996756 12.99 µM -1.1002917902123 0.178395461724499 no 2750 0.135602504014753 4212 2241621 SGTC_2394 5221648 200 µM -1.10151163423862 0.178094816096176 no 2751 0.135337021900478 4242 788586 SGTC_664 1222-0054 14.9 µM -1.10214588192334 0.177938624209257 no 2752 0.135199127564249 4166 6813991 SGTC_1412 3909-8563 178 µM -1.10287388986008 0.177759449138693 no 2753 0.13504096721334 4269 23767530 SGTC_2690 usnic acid 100 µM -1.10393928679852 0.17749744217327 no 2754 0.134809737615173 4230 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1720 st037298 9.481 µM -1.10825722496296 0.17643805410207 no 2755 0.133875371586504 4196 597396 SGTC_1033 k072-0102 21.3 µM -1.1083031323467 0.176426812449318 no 2756 0.133865461580446 4163 5965931 SGTC_1781 st038725 66.3 µM -1.10851381970637 0.176375225816848 no 2757 0.13381998706271 4186 4270275 YIL048W NEO1 SGTC_1121 fusaric acid 630.51 nM -1.10883310646684 0.176297066899035 no 2758 0.133751092815586 4165 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1797 st048695 56.8 µM -1.10926826680382 0.176190578326688 no 2759 0.133657235162111 4172 592262 YIL048W NEO1 SGTC_3 0833-0587 95.581 µM -1.10966759808965 0.176092893350308 no 2760 0.133571145160065 4083 5382644 SGTC_1005 4092-0690 4.4 µM -1.11070717937949 0.175838750369355 no 2761 0.133347205472567 4225 1529343 SGTC_3223 9129970 49.47 µM -1.1112659600844 0.175702243152512 no 2762 0.133226943437455 4220 17248386 SGTC_1893 st059353 36.1 µM -1.11177884170465 0.175577007954248 no 2763 0.133116625613955 4217 3112488 SGTC_2402 5553605 200 µM -1.11273987884839 0.175342494697963 no 2764 0.132910081484194 4296 6758546 SGTC_3071 9117417 49.47 µM -1.1137349535789 0.175099884932754 no 2765 0.132696454689055 4163 45595590 YGL055W OLE1 SGTC_2948 9070189 9.45 µM -1.11375173989287 0.175095794078739 no 2766 0.132692852962766 4159 6473636 YDL196W YDL196W SGTC_2057 5236571 38.335 µM -1.11635624355305 0.174461806546074 no 2767 0.132134837743958 4192 54684039 YBR257W POP4 SGTC_591 4299-0174 154 µM -1.11660404850672 0.174401561993211 no 2768 0.132081829922954 4222 5509088 SGTC_1780 st038448 24.544 µM -1.11716958923895 0.17426412131347 no 2769 0.131960910341487 4258 728868 YDL195W SEC31 SGTC_1973 st070275 50.2 µM -1.11744145813825 0.174198074808114 no 2770 0.131902808601405 4157 17118334 SGTC_143 4032-1194 15.74 µM -1.11836969942818 0.173972692296498 no 2771 0.13170456496842 4229 1806963 SGTC_2094 5332512 191.667 µM -1.11838975929022 0.173967823690161 no 2772 0.131700283073017 4243 755774 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.1195097012459 0.173696146871092 no 2773 0.131461377264365 4258 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2515 chrysin 20.77 µM -1.11970783627917 0.173648111159387 no 2774 0.131419142302675 4237 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_363 0455-0021 3.06 µM -1.12241404462646 0.172992866263683 no 2775 0.130843217829362 4176 4597466 SGTC_1482 3346-2049 8.48 µM -1.12430080662746 0.172536964312753 no 2776 0.130442718150523 4224 3826804 SGTC_631 k072-0230 41.5 µM -1.12444632357582 0.172501834624077 no 2777 0.13041186477772 4228 5773147 SGTC_1342 1486-1464 234 µM -1.12510774057031 0.172342217429813 no 2778 0.130271690809599 4237 3253938 SGTC_2490 carminic acid 95.39 µM -1.12583600124612 0.172166578133085 no 2779 0.130117471286529 4188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_539 4859-0462 2.54 µM -1.12625926381842 0.172064549693126 no 2780 0.130027897514146 4264 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1286 0929-0070 131 µM -1.12761407539032 0.171738228718595 no 2781 0.129741469850573 4282 1420408 SGTC_1405 3909-7894 12 µM -1.12937239605908 0.171315308066795 no 2782 0.129370386212207 4219 7104060 SGTC_3032 9089427 49.47 µM -1.12945643094494 0.171295112233176 no 2783 0.129352669559493 4216 17173707 SGTC_1987 st072290 61.9 µM -1.12948840056534 0.171287429476902 no 2784 0.129345930006593 4230 54697379 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.12956130615595 0.171269910046507 no 2785 0.129330561604422 4188 688761 SGTC_2971 9092186 9.93 µM -1.13054155581654 0.171034464400959 no 2786 0.129124049164061 4225 25236400 SGTC_896 0964-0007 44.5 µM -1.13170448212091 0.170755410389749 no 2787 0.128879348269986 4188 6756758 SGTC_1443 4112-3303 14 µM -1.13316202970074 0.170406071240574 no 2788 0.128573108145502 4271 704433 SGTC_2488 5268135 45.7 µM -1.13496655720055 0.169974203978955 no 2789 0.128194665451575 4290 1270356 YLR208W SEC13 SGTC_1009 4106-0057 9.87 µM -1.13563134987261 0.169815279950212 no 2790 0.128055441355644 4226 2928005 SGTC_1775 st081588 35.1725 µM -1.13577598443795 0.169780716519724 no 2791 0.128025165202445 4236 1426443 YGL099W LSG1 SGTC_2103 5378138 10 µM -1.14341446459121 0.167961755563786 no 2792 0.126433274858522 4299 244142 SGTC_2237 6667747 47.222 µM -1.14347272640749 0.167947929980776 no 2793 0.126421186090422 4244 729940 YDL015C TSC13 SGTC_1531 st059297 52.4 µM -1.1465252282916 0.167224593134492 no 2794 0.125788947346807 4260 7566702 SGTC_54 0159-0055 9 µM -1.14852125370061 0.166752692036116 no 2795 0.125376722101515 4245 3319099 SGTC_2158 5657123 3.6195 µM -1.15043850892564 0.166300223663074 no 2796 0.124981653513983 4209 2858827 SGTC_623 k072-0108 16.9 µM -1.15091091547652 0.1661888585319 no 2797 0.124884443349914 4208 5382803 SGTC_79 0052-0007 94.094 µM -1.15192106881038 0.165950886639773 no 2798 0.124676754820806 4245 2801472 SGTC_1117 retinoic acid 1.10837 µM -1.15312183697625 0.165668296331148 no 2799 0.12443018988106 4283 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_484 loperamide 105 µM -1.15562813703365 0.165079463656937 no 2800 0.123916646959372 4279 3955 An opioid-receptor agonist. SGTC_2561 acetosyringone 100 µM -1.15567052688863 0.165069516207398 no 2801 0.123907974019301 4223 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2095 5432005 200 µM -1.15720294826198 0.164710169910275 no 2802 0.123594726743818 4246 783734 SGTC_496 calpeptin 138 µM -1.15777262630616 0.164576712151543 no 2803 0.123478418510711 4251 73364 A calpain inhibitor. SGTC_961 1252-1571 372 µM -1.15852378599514 0.1644008460648 no 2804 0.123325175325496 4258 6813498 SGTC_2899 9053889 58.44 µM -1.1585441666629 0.164396076116797 no 2805 0.123321019347527 4216 6470052 SGTC_747 3448-8087 38.7 µM -1.16055127160689 0.163926767209926 no 2806 0.122912215804983 4317 5168703 SGTC_1925 st057770 10.1 µM -1.16352117367232 0.163233929932054 no 2807 0.122309056251721 4239 5989122 SGTC_1211 1056-0033 32.3 µM -1.1641082730143 0.163097193309546 no 2808 0.122190068190879 4308 6741922 SGTC_2339 9000433 200 µM -1.16508618068288 0.162869601960607 no 2809 0.121992055051741 4267 2988954 SGTC_1207 2099-0101 141 µM -1.16954552454091 0.161834385013248 no 2810 0.121091955352132 4248 5837381 SGTC_2462 5162487 171.77 µM -1.17064061848738 0.161580820947178 no 2811 0.120871631609592 4221 2259986 SGTC_2689 tacrolimus 100 µM -1.17080343134826 0.161543144490695 no 2812 0.120838899128649 4283 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1907 st060210 83.7 µM -1.17085446822049 0.161531335248508 no 2813 0.120828639777382 4292 688793 SGTC_746 1095-0025 46.6 µM -1.17194253424149 0.161279705394745 no 2814 0.120610064304739 4279 6749286 SGTC_1097 itavastatin 7.23 µM -1.17259871890493 0.161128077558417 no 2815 0.120478381700862 4275 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_842 0271-0008 11.1 µM -1.17574736129371 0.160401799617278 no 2816 0.11984792334086 4304 1221709 SGTC_1124 fisetin 1.16336 µM -1.17623861744883 0.160288677796122 no 2817 0.119749768385434 4279 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.1804276135004 0.159326193887095 no 2818 0.118915092353641 4317 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1641 st009299 47.1 µM -1.18053725324173 0.159301053459356 no 2819 0.118893301463666 4202 4046054 SGTC_947 3447-0010 211 µM -1.18140886253668 0.159101285587707 no 2820 0.118720169506002 4229 748350 SGTC_2702 st077768 96.8 µM -1.1835711638756 0.158606407360066 no 2821 0.118291430396785 4255 6484119 SGTC_641 4092-0595 30 µM -1.18389348087628 0.158532726349983 no 2822 0.118227615548282 4315 786260 SGTC_875 0709-0210 25.7 µM -1.18402919602378 0.158501708860727 no 2823 0.11820075288267 4268 6251364 SGTC_2841 9004761 38.96 µM -1.18613809708974 0.158020234263168 no 2824 0.117783883815018 4248 2991039 SGTC_2693 st077581 40.7 µM -1.18760198972043 0.15768658407305 no 2825 0.117495126785712 4297 25238761 SGTC_1155 4088-0394 48.2 µM -1.18773894750843 0.157655392365867 no 2826 0.117468137130354 4252 2326248 SGTC_657 3534-0529 86.7 µM -1.1885352324663 0.157474121260974 no 2827 0.11731130379011 4315 1049549 SGTC_2262 9014885 67.46 µM -1.1889900135922 0.157370653625504 no 2828 0.117221798346612 4269 6457424 SGTC_3142 9086498 49.47 µM -1.19136377327199 0.156831323079439 no 2829 0.116755404059658 4148 25236367 SGTC_2344 7990960 76.95 µM -1.19142687103208 0.156817003554498 no 2830 0.116743024640713 4250 140813 SGTC_982 1491-0518 27.5 µM -1.19598248681543 0.15578541698156 no 2831 0.115851696723096 4195 3091256 SGTC_412 gemfibrozil 100 µM -1.19598396494441 0.155785082997636 no 2832 0.115851408306516 4212 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2113 5491891 107.031 µM -1.1964563104231 0.155678380500173 no 2833 0.115759269074352 4279 789979 SGTC_852 0418-0143 439 µM -1.19755854977181 0.155429572952856 no 2834 0.115544460505125 4280 5369229 SGTC_1007 4101-0031 70 µM -1.19927886275992 0.155041772771112 no 2835 0.11520976561338 4250 1146276 SGTC_2074 5212007 75.395 µM -1.20208713311384 0.154410094578647 no 2836 0.114664885485545 4175 758611 SGTC_2136 5328288 199.296 µM -1.20276190313974 0.154258569098468 no 2837 0.114534235609291 4264 262395 SGTC_2642 cholecalciferol 100 µM -1.2043863272882 0.153894193967871 no 2838 0.114220147090709 4272 9821465 A vitamin D precursor, similar to steriods. SGTC_649 1123-0311 367 µM -1.20868249195956 0.152933267202523 no 2839 0.113392425261199 4198 693629 YIL048W NEO1 SGTC_3214 9129694 49.47 µM -1.21106982208442 0.152401014284105 no 2840 0.112934323045681 4327 17158655 SGTC_2940 9060638 45.86 µM -1.21146796975909 0.152312367411902 no 2841 0.112858051626822 4287 4027022 SGTC_1946 st076057 65.1 µM -1.21532395573477 0.151455610223991 no 2842 0.112121279321155 4240 953009 SGTC_556 4058-0063 51.5 µM -1.21747981120301 0.150978002410808 no 2843 0.111710856589472 4342 6615692 SGTC_3144 9087057 49.47 µM -1.2195420862942 0.150522065407516 no 2844 0.111319256103299 4208 17249618 SGTC_944 3370-0224 231 µM -1.2218475736354 0.150013444819367 no 2845 0.110882637085373 4310 4580514 SGTC_2492 derrusnin 100 µM -1.22258902946695 0.14985011380158 no 2846 0.110742479376123 4329 1715307 Part of coumarin class of compounds. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.22396312231023 0.1495477365259 no 2847 0.110483069752964 4288 688669 SGTC_651 3253-0966 34.4 µM -1.22497330044057 0.149325700727458 no 2848 0.110292640214626 4322 781462 SGTC_1740 st038286 13.222 µM -1.22502731360196 0.149313834908928 no 2849 0.110282464781104 4331 716786 SGTC_599 1935-0052 86.5 µM -1.22546002045092 0.149218798931042 no 2850 0.110200972286566 4296 9557311 SGTC_919 tnp00227 403.569 nM -1.22571187882065 0.149163501545745 no 2851 0.11015355921734 4262 1269246 A methoxyflavone. YNL221C POP1 SGTC_878 0828-0289 13.7 µM -1.22697061188061 0.148887342441797 no 2852 0.1099168183725 4257 745350 YLR208W SEC13 SGTC_187 1488-2104 32.728 µM -1.22742733105355 0.148787225291236 no 2853 0.10983100957689 4309 2852859 SGTC_3329 9141233 27.5565 µM -1.23089717604001 0.148028072161372 no 2854 0.109180661970021 4275 4909101 YNL103W MET4 SGTC_1173 0443-0020 122 µM -1.23183089765438 0.147824230498205 no 2855 0.109006129442865 4304 5331295 SGTC_2608 thymoquinone 42.66 µM -1.23214062973615 0.147756654121918 no 2856 0.108948278214946 4285 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1276 0871-0068 94.2 µM -1.23357445421571 0.14744409635211 no 2857 0.108680758499451 4325 3414906 SGTC_1969 st069479 40.1 µM -1.23629324411557 0.146852647671901 no 2858 0.108174790718553 4321 3895485 SGTC_2665 lovastatin 100 µM -1.23761162081074 0.146566420242716 no 2859 0.107930051720777 4336 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_734 2023-0417 80 µM -1.23971437677437 0.146110674730948 no 2860 0.107540528811827 4328 3935732 SGTC_1496 4469-0713 57.4 µM -1.24009222563272 0.146028881820778 no 2861 0.107470642092082 4301 746691 SGTC_3177 9107506 49.47 µM -1.24388579697191 0.145209392719609 no 2862 0.106770798688912 4273 8897194 SGTC_702 1488-0190 94 µM -1.24604219945201 0.144744947702441 no 2863 0.106374451530997 4348 949357 SGTC_1278 0874-0585 172 µM -1.24708229590724 0.144521290224207 no 2864 0.106183661882126 4379 766306 SGTC_509 pifithrin 175 µM -1.24737922840744 0.144457481996734 no 2865 0.106129239580689 4398 4817 A p53 inhibitor. SGTC_298 1391-0729 10 µM -1.249711766829 0.143956899988822 no 2866 0.105702428676193 4268 3237558 SGTC_844 0330-0132 15.3 µM -1.2515994816581 0.143552638363964 no 2867 0.105357921783966 4373 2828079 SGTC_3037 9091026 49.47 µM -1.25175520886425 0.143519323013423 no 2868 0.105329537966449 4225 25236398 YIL048W NEO1 SGTC_3233 9132340 49.47 µM -1.25251353029006 0.14335716683863 no 2869 0.105191400602498 4331 17682950 SGTC_68 0986-0284 82.829 µM -1.25401965408168 0.14303547082784 no 2870 0.104917430893515 4354 423278 YIL048W NEO1 SGTC_2645 abamectin 100 µM -1.25433165257879 0.142968891473542 no 2871 0.104860741816027 4287 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2364 9055074 200 µM -1.2598822721269 0.14178790941625 no 2872 0.103855917409693 4341 6470630 SGTC_301 4119-0100 24.5 µM -1.26078361418723 0.141596759973071 no 2873 0.103693409487314 4368 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_257 daunorubicin 18.5 µM -1.26237390559488 0.141259929568459 no 2874 0.103407137146281 4367 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3232 9132874 49.47 µM -1.26299711589482 0.141128079268861 no 2875 0.103295108103433 4292 3784940 SGTC_2829 7992743 58.44 µM -1.26404266873289 0.140907063014738 no 2876 0.10310735622586 4341 16462845 SGTC_2456 5770359 74.46 µM -1.27351458365809 0.138915523201052 no 2877 0.10141775043551 4349 3118787 SGTC_626 0214-0009 33 µM -1.27508158521486 0.13858790636746 no 2878 0.10114018326426 4406 3437874 SGTC_609 0986-0026 86.3 µM -1.27554080510276 0.138491995966539 no 2879 0.101058945411625 4311 2848610 SGTC_419 nsc-638432 893 µM -1.27573865784423 0.13845068736364 no 2880 0.101023959126554 4311 368090 SGTC_942 3253-1115 227 µM -1.27663624290174 0.138263390897971 no 2881 0.100865350107996 4371 46497897 SGTC_3197 9113331 49.47 µM -1.27732713532767 0.138119342082406 no 2882 0.100743388720953 4343 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2437 5741531 144.16 µM -1.28247715536418 0.137048804597372 no 2883 0.0998376568578273 4371 2262990 SGTC_2626 ethyl orsellinate 100 µM -1.28728253259887 0.136055033897866 no 2884 0.0989979147640778 4306 75653 A natural product. SGTC_2159 5658611 73.75 µM -1.29038995964421 0.135415038422004 no 2885 0.0984576482057649 4347 793844 SGTC_2449 5812982 45.77 µM -1.29305582021231 0.134867633276192 no 2886 0.0979958768572593 4290 776185 SGTC_805 3852-0218 479 µM -1.29341181803411 0.134794648099297 no 2887 0.0979343324350035 4322 6615355 SGTC_1556 plumbagin 1.48 µM -1.30114282590582 0.133216351775286 no 2888 0.0966047855702224 4292 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1644 st010134 20.9 µM -1.30358696223455 0.132720034155555 no 2889 0.0961872241778236 4349 3818134 SGTC_2092 5303694 80.6725 µM -1.30373131589364 0.132690760917553 no 2890 0.0961626040540908 4370 1963699 SGTC_234 nsc-17383 10.7 µM -1.30576691644174 0.132278438373504 no 2891 0.0958159169610495 4378 408974 SGTC_3208 9114115 49.47 µM -1.3057769379721 0.132276410642286 no 2892 0.0958142124520064 4364 650895 SGTC_521 r062-0005 13.8 µM -1.30969490575671 0.131485300122652 no 2893 0.0951495338115501 4296 2832033 SGTC_2260 7964312 200 µM -1.31106623939888 0.131209175610874 no 2894 0.0949176927848038 4428 231951 SGTC_768 0384-0033 77.3 µM -1.31378966914123 0.130661988301646 no 2895 0.0944584975709487 4325 3965305 YMR134W ERG29 SGTC_2871 9038510 12.99 µM -1.31396721658662 0.13062637060144 no 2896 0.0944286184166208 4358 4945164 SGTC_1990 st072050 59.8 µM -1.31401936599987 0.130615910210468 no 2897 0.0944198436057822 4356 17233948 SGTC_252 miconazole 1.30953 nM -1.3178361404019 0.129851894450011 no 2898 0.0937792534098121 4273 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2796 7949634 45.45 µM -1.31850071715262 0.129719180964525 no 2899 0.0936680425708217 4345 2971588 SGTC_549 1661-1316 519 µM -1.32244393581183 0.128933667332421 no 2900 0.0930101833531954 4410 2857282 SGTC_409 arachidonic acid 100 µM -1.32709973210476 0.128010458549982 no 2901 0.0922378469738776 4370 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_809 3998-0021 90 µM -1.32754549734226 0.127922308221144 no 2902 0.092164150035884 4334 715485 SGTC_387 norethindrone acetate 66.7 µM -1.32829460164898 0.127774267431438 no 2903 0.0920404012128151 4395 541197 SGTC_2504 purpurogallin 52.29 µM -1.33161112071088 0.127120275315376 no 2904 0.0914940043595586 4295 5281571 An antioxidant. SGTC_1104 tacrolimus 29.8 µM -1.3327801646757 0.126890304998842 no 2905 0.0913019784198829 4452 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2087 5276107 200 µM -1.33427300864853 0.126597059125791 no 2906 0.0910572000357396 4352 144405 SGTC_656 4090-1979 187 µM -1.33570242462402 0.126316715366273 no 2907 0.0908232782845795 4407 22330961 SGTC_1886 st057356 49.9 µM -1.33774921749069 0.125916042467283 no 2908 0.0904891005350575 4373 24207747 SGTC_3250 9135583 49.47 µM -1.33936904843536 0.125599579001625 no 2909 0.0902252801941088 4411 7699353 SGTC_1066 ketoconazole 628 nM -1.33959438106761 0.125555600179175 no 2910 0.0901886257927619 4453 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_320 4092-0846 5.34 µM -1.34190774562163 0.125104715541364 no 2911 0.0898129550038566 4354 1359356 SGTC_2678 equilin 100 µM -1.34285595844002 0.124920231949932 no 2912 0.0896593098193308 4388 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2977 9011197 71.43 µM -1.34427085821544 0.124645303618601 no 2913 0.089430407766461 4442 2704722 SGTC_2046 4110841 106 µM -1.34716525616485 0.124084213075985 no 2914 0.0889635075286488 4396 44119630 YMR134W ERG29 SGTC_1861 st057647 17.4 µM -1.34825243273716 0.123873916833283 no 2915 0.0887886028282837 4447 688668 SGTC_1825 st052143 62.6 µM -1.3517970690073 0.123189998964197 no 2916 0.0882201210198087 4446 674173 SGTC_820 1582-0060 59.9 µM -1.35373966265546 0.122816310858679 no 2917 0.0879097247525342 4432 3848840 SGTC_1241 0364-0022 50.8 µM -1.35435390321084 0.122698317723269 no 2918 0.0878117483391315 4394 4563895 SGTC_536 3852-0578 10.6 µM -1.35746986494275 0.122100978884984 no 2919 0.0873159811632399 4435 2869208 SGTC_972 1319-0219 195 µM -1.35748606193982 0.122097879218195 no 2920 0.0873134095996479 4395 23903702 SGTC_191 3914-0123 66.505 µM -1.3584034955094 0.121922397463364 no 2921 0.0871678428620731 4436 3144412 SGTC_460 trequinsin 123 µM -1.3623725033199 0.121165268297221 no 2922 0.0865401784227813 4492 5537 A vasodilator. SGTC_586 0957-0265 8.15 µM -1.36303152649079 0.121039873672996 no 2923 0.0864362874733171 4287 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_843 0310-0051 143 µM -1.366697019938 0.1203440936436 no 2924 0.0858601461689661 4438 2065037 SGTC_2586 curcumin 80 µM -1.3667543068514 0.120333241909458 no 2925 0.0858511646936535 4309 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2270 7924575 90.91 µM -1.37045588360788 0.119633521064551 no 2926 0.0852723188651221 4390 1262135 SGTC_725 1497-0963 19 µM -1.3704825575961 0.119628489231859 no 2927 0.0852681582730409 4506 3549977 SGTC_3007 9078383 71.4286 µM -1.37450545290545 0.118871310740449 no 2928 0.0846424092844011 4424 6496995 SGTC_1041 0206-0046 107 µM -1.37736907186953 0.118334394473314 no 2929 0.0841990849770721 4416 50494 SGTC_2105 5350118 200 µM -1.37741983529211 0.118324892040141 no 2930 0.084191241911351 4391 2133313 SGTC_2090 5301565 104.445 µM -1.37774543936119 0.118263954861251 no 2931 0.0841409483712886 4429 2056344 SGTC_1678 st019265 80.2 µM -1.37830682690512 0.118158942646866 no 2932 0.0840542881523284 4409 5367020 SGTC_534 k292-0788 63.4 µM -1.37836838572359 0.118147431570396 no 2933 0.0840447895249272 4467 4146317 SGTC_1219 1469-0211 33.1 µM -1.3792277071244 0.117986827166786 no 2934 0.0839122789468146 4428 6822282 SGTC_2764 methyldopa 94.69 µM -1.37956557092827 0.117923723826216 no 2935 0.083860222075798 4393 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3025 9087895 49.47 µM -1.38421802305908 0.117057205629714 no 2936 0.0831458531601968 4386 17173641 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.38559398138353 0.116801800337181 no 2937 0.0829354585313401 4464 65057 A dermal irritant. YDR527W RBA50 SGTC_206 4546-0025 72.014 µM -1.38671460621882 0.116594082107606 no 2938 0.0827644024695881 4464 6620745 YIL048W NEO1 SGTC_2644 guaiazulene 100 µM -1.38775049501511 0.116402303614599 no 2939 0.0826065170605026 4454 3515 A coloring agent. SGTC_1479 0549-0158 134 µM -1.3910392796894 0.115794920296398 no 2940 0.0821067579590579 4481 5440202 SGTC_2453 5731132 22.18 µM -1.39138863498076 0.11573053272663 no 2941 0.0820538045334438 4457 1362040 SGTC_2130 NSC 7 2.4545 µM -1.39583793384808 0.114912732764198 no 2942 0.0813816521636953 4485 21448 SGTC_1892 st058411 7.36 µM -1.3959182763661 0.114898003348072 no 2943 0.0813695531662254 4428 3934738 SGTC_1813 st051246 8.6015 µM -1.39763494970375 0.114583601732583 no 2944 0.0811113587838773 4379 5291959 SGTC_482 fipronil 114 µM -1.39875638756128 0.114378545956013 no 2945 0.080943024313511 4548 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1388 3346-4487 254 µM -1.39956267323511 0.114231277536543 no 2946 0.080822159109193 4507 3345614 SGTC_1150 3909-7983 10.9 µM -1.40729349299371 0.112826091429961 no 2947 0.0796701890230402 4440 23965914 SGTC_497 capsazepine 133 µM -1.40759436995599 0.112771653375033 no 2948 0.0796256077591612 4387 2733484 A calcium channel blocker. SGTC_2153 5569715 200 µM -1.40862538389698 0.112585252945607 no 2949 0.0794729844577327 4455 2054701 SGTC_1988 st071872 53.4 µM -1.41091312297027 0.112172431145502 no 2950 0.0791351161110424 4466 16414116 SGTC_85 0868-0259 160.055 µM -1.41195238719387 0.111985254058846 no 2951 0.0789819905010633 4375 83173 SGTC_1656 st012921 11 µM -1.41336636694475 0.111730947452823 no 2952 0.0787740146821281 4352 6732821 SGTC_1819 st053448 58.6 µM -1.4137234460719 0.111666791563182 no 2953 0.0787215592303073 4370 2857616 SGTC_2513 baicalein 25.65 µM -1.41478350256973 0.11147648800862 no 2954 0.0785659912895365 4437 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2234 tolnaftate 200 µM -1.4174881015332 0.110992004541632 no 2955 0.0781701353361108 4552 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3311 9131146 2.8755 µM -1.41806816190536 0.110888293179708 no 2956 0.0780854327398499 4387 4900406 YPR165W RHO1 SGTC_2594 a-mangostin 100 µM -1.41850090754512 0.110810966048925 no 2957 0.0780222869560122 4441 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1008 4106-0037 6 µM -1.42358734146835 0.109904968087223 no 2958 0.0772829811667282 4479 2905394 SGTC_567 1080-0542 68.4 µM -1.42527424188838 0.109605673686022 no 2959 0.0770389714367092 4339 5950415 SGTC_637 1181-0519 7.26 µM -1.42581510301155 0.10950983666365 no 2960 0.0769608600990535 4460 6252091 YGR060W ERG25 SGTC_2877 9040724 71.43 µM -1.43154550199577 0.10849814255371 no 2961 0.0761369679568573 4421 6463895 SGTC_1574 spiramycin 23.7 µM -1.43452319402333 0.10797509777544 no 2962 0.0757115075355506 4423 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2794 7785382 27.27 µM -1.43508769539063 0.107876145688681 no 2963 0.07563105471323 4460 2205081 SGTC_571 k831-0106 44.2 µM -1.44036561377993 0.106954132105427 no 2964 0.0748819934352919 4357 4783639 SGTC_1688 st021091 57.6 µM -1.44081979380448 0.106875056646402 no 2965 0.0748177999675969 4488 3656366 SGTC_1076 itraconazole 331 nM -1.44566092561895 0.106034806558248 no 2966 0.0741361645240319 4465 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_185 k048-0037 25.491 µM -1.44633680629951 0.105917878230285 no 2967 0.07404137852775 4507 6827589 SGTC_2278 7948257 134.34 µM -1.44655846171096 0.105879551824617 no 2968 0.074010313581125 4462 1247028 SGTC_2235 salicylic acid 500 µM -1.44736990736218 0.105739330386128 no 2969 0.073896674640741 4518 338 A COX inhibitor and kinase inhibitor. SGTC_1148 3909-7663 27.7 µM -1.45007152305706 0.105273446746399 no 2970 0.0735192876263955 4503 4084526 SGTC_499 genistein 192 µM -1.45147090298682 0.105032713539663 no 2971 0.0733243893991327 4561 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1261 0712-0010 12.7 µM -1.45473984856864 0.104471914929109 no 2972 0.072870648147616 4449 2840123 SGTC_1072 oxiconazole 14.9 nM -1.45617679835167 0.104226088971366 no 2973 0.0726718758300017 4458 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.45793197250579 0.103926392011729 no 2974 0.0724296473933562 4481 5377381 SGTC_2731 amoxapine 43.43 µM -1.45898050488389 0.103747652994188 no 2975 0.0722852367474874 4630 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1634 st006576 41 µM -1.46020327399881 0.103539494356526 no 2976 0.0721171079012429 4453 3915356 SGTC_1464 k208-0027 110 µM -1.4609728583354 0.103408639336975 no 2977 0.0720114450589514 4472 X1464 SGTC_1308 1187-1617 41.4 µM -1.46364181312165 0.102955758090962 no 2978 0.0716459208027133 4507 2882570 SGTC_1751 st044839 27.194 µM -1.46381746226193 0.102926003702799 no 2979 0.0716219149484954 4522 5291326 SGTC_1847 st056231 15 µM -1.46726371861844 0.10234348238544 no 2980 0.0711521646703091 4464 5393180 SGTC_751 0833-0568 350 µM -1.4672847783498 0.102339930041144 no 2981 0.0711493013630023 4479 6954252 SGTC_6 0844-0013 19.835 µM -1.46811272364018 0.102200343722383 no 2982 0.0710368029892841 4595 1584900 SGTC_1648 st011736 69.8 µM -1.47056485191378 0.101787743069771 no 2983 0.0707044175922591 4466 2855514 SGTC_1560 lithocholic acid 53.1 µM -1.47143086113072 0.101642316530754 no 2984 0.0705873162529509 4419 9903 A bile acid which acts as a detergent. SGTC_1103 duloxetine 36.1 µM -1.47252150312637 0.101459383347289 no 2985 0.0704400523297496 4535 60835 A selective serotonin reuptake inhibitor. SGTC_3008 9078912 71.4286 µM -1.47339454048614 0.101313121851978 no 2986 0.0703223407743024 4507 16648731 SGTC_3034 9090421 49.47 µM -1.47459259349969 0.101112660035609 no 2987 0.0701610536675562 4395 17173761 SGTC_3078 9116413 49.47 µM -1.4783963626114 0.100478118168629 no 2988 0.0696508592153089 4433 17177322 SGTC_917 harmaline 728.087 nM -1.4801105888497 0.100193103922623 no 2989 0.0694218680841282 4413 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_194 1486-1323 56.904 µM -1.48168979351245 0.09993106160047 no 2990 0.0692114270430662 4568 5178754 SGTC_224 benfluorex 43.875 µM -1.48251193230306 0.0997948398405676 no 2991 0.0691020655065483 4485 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1118 chelidonine 707.474 nM -1.48332949250738 0.099659511281298 no 2992 0.0689934451185099 4474 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2976 9009005 19.48 µM -1.48456584025365 0.0994551167228662 no 2993 0.0688294349954913 4475 2993148 SGTC_778 3456-2434 196 µM -1.48458845820223 0.0994513803513883 no 2994 0.0688264373696568 4415 5539063 SGTC_2811 7967822 32.47 µM -1.48639410636133 0.0991534273020435 no 2995 0.0685874539076111 4497 2232244 SGTC_63 0099-0242 26.702 µM -1.4923962566466 0.0981676946609218 no 2996 0.0677976478986026 4504 3898502 YLR359W ADE13 SGTC_2769 toremifene 3.73 µM -1.49277845183609 0.0981051707698596 no 2997 0.0677475947999689 4494 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3014 9081533 49.47 µM -1.49671782208675 0.0974624226787599 no 2998 0.0672333484539401 4514 21367265 SGTC_771 0250-0039 27.3 µM -1.49862232696911 0.0971527933465892 no 2999 0.0669858186046098 4436 3005115 SGTC_2104 5389443 200 µM -1.49927885260038 0.0970462246518616 no 3000 0.0669006530733614 4512 2244536 SGTC_40 0327-0103 19.753 µM -1.49932834521568 0.0970381943802899 no 3001 0.066894236210813 4348 409036 SGTC_204 PMA1.184 62.41 µM -1.50283561052326 0.0964703751295722 no 3002 0.0664407202538733 4461 2252213 YGL008C PMA1 SGTC_1380 2291-0730 164 µM -1.50396769187026 0.0962876156151135 no 3003 0.0662948428763014 4503 2999191 SGTC_2833 9001315 45.46 µM -1.5070283950966 0.0957947799480332 no 3004 0.0659016895170847 4449 2989378 SGTC_959 1222-0044 107 µM -1.50813008969334 0.0956178395763916 no 3005 0.0657606177480728 4491 6083612 SGTC_901 1112-0062 60.1 µM -1.51072288946809 0.0952023658153514 no 3006 0.0654295340438998 4486 1908457 SGTC_230 MPP+ 141.667 µM -1.5113054053399 0.0951092058367033 no 3007 0.0653553287094141 4472 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1553 gossypol 38.6 µM -1.5123966933084 0.0949348602350776 no 3008 0.0652164878149957 4418 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2876 9059903 25.97 µM -1.51421663145426 0.094644628460873 no 3009 0.0649854524228966 4497 6916095 SGTC_2316 5844804 197.44 µM -1.51449931464167 0.0945996067487465 no 3010 0.0649496237594752 4515 776813 SGTC_1953 st076800 12.1 µM -1.5159227860637 0.0943731365833765 no 3011 0.0647694389320107 4470 297591 SGTC_2947 9072639 7.68 µM -1.51707717157619 0.0941897709928378 no 3012 0.0646236005693066 4442 16488146 SGTC_639 0833-0042 114 µM -1.51741561417794 0.0941360617456195 no 3013 0.0645808920815851 4519 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2892 9047358 58.44 µM -1.51962483255373 0.0937860242055684 no 3014 0.0643026465436602 4511 6466771 SGTC_218 alverine citrate 93.75 µM -1.52001909141727 0.0937236573944176 no 3015 0.0642530887377285 4557 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3236 9132701 49.47 µM -1.52045459667244 0.0936548015181273 no 3016 0.0641983808275397 4503 24282524 SGTC_1078 idebenone 36.1 µM -1.52648410648608 0.0927053366923321 no 3017 0.0634446728236083 4523 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1849 st056239 19.2 µM -1.52770137098432 0.0925145211854219 no 3018 0.0632933497913432 4502 5393181 SGTC_1810 st050138 53 µM -1.5312333131595 0.0919625071793281 no 3019 0.062855870146965 4519 3444541 SGTC_1145 3546-0597 10.2 µM -1.53364502589676 0.0915869798346338 no 3020 0.0625585024699638 4486 875334 SGTC_184 1494-0393 24.714 µM -1.53603873033294 0.0912153813884623 no 3021 0.0622644408275853 4495 3090647 SGTC_1529 apigenin 74 µM -1.53791118776265 0.090925481472369 no 3022 0.0620351657180701 4516 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_940 3232-1287 54.8 µM -1.53925247972439 0.0907182388847431 no 3023 0.061871335093239 4494 1585493 YIL048W NEO1 SGTC_920 mycophenolic acid 780.421 nM -1.54011791877647 0.0905847063697424 no 3024 0.0617658063666297 4494 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1210 3013-0140 750 nM -1.54045899160768 0.0905321207969757 no 3025 0.0617242557132389 4531 905973 SGTC_403 arphamenine a 50 µM -1.54076993214895 0.0904842006799104 no 3026 0.0616863948964101 4519 5487158 An arginine aminopeptidase inhibitor. SGTC_2116 5511452 16.8835 µM -1.54228883680905 0.0902503877123165 no 3027 0.0615017102210724 4523 870744 SGTC_991 3996-0057 64.7 µM -1.54557374427551 0.0897462598801286 no 3028 0.0611037731276795 4552 715343 SGTC_1 0258-0098 57.368 µM -1.54761680958116 0.0894337726132978 no 3029 0.0608572909243457 4432 6790032 YDR047W HEM12 SGTC_977 1348-1378 135 µM -1.54835492733133 0.0893210765821449 no 3030 0.0607684333553919 4498 X977 SGTC_2552 juarezic acid 87.02 µM -1.54842139051688 0.0893109341508851 no 3031 0.0607604372330627 4474 1549512 SGTC_353 1988-1175 58.3 µM -1.54891611093105 0.0892354656289968 no 3032 0.0607009437478422 4338 2788357 SGTC_3059 1327-0034 3 µM -1.54983989186101 0.0890946719004068 no 3033 0.0605899748041365 4382 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2653 dihydrofissinolide 100 µM -1.55549592509947 0.0882362373449007 no 3034 0.059914002155585 4583 6857746 SGTC_2396 5342950 42.78 µM -1.55633600548615 0.0881092632270532 no 3035 0.0598141069343785 4513 1886677 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.55650911068609 0.0880831161419766 no 3036 0.0597935389567819 4535 15053 SGTC_1251 0490-5699 265 µM -1.55813662024054 0.0878375679233556 no 3037 0.0596004326952766 4532 3883818 SGTC_2457 5731572 11.68 µM -1.55900239065391 0.0877071542432375 no 3038 0.0594979071672367 4570 2865357 SGTC_888 0916-0002 6.97 µM -1.55971338515247 0.0876001630079541 no 3039 0.0594138138015526 4536 2802138 YIL048W NEO1 SGTC_1402 3909-7673 35.9 µM -1.56118128198743 0.0873795804114065 no 3040 0.0592404920702285 4551 5328014 SGTC_904 1141-0088 396 µM -1.56351424500505 0.0870298568242443 no 3041 0.0589658438865464 4534 1378119 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.56485313285359 0.086829623140042 no 3042 0.0588086750132996 4513 689007 SGTC_935 2996-0153 430 µM -1.56538417136726 0.0867503005455638 no 3043 0.0587464287917627 4532 23738523 SGTC_1365 1672-3266 55.4 µM -1.56672913614363 0.0865496419541498 no 3044 0.0585890087027735 4548 6415873 SGTC_1437 4092-1038 11.6 µM -1.56947031769788 0.0861417528746644 no 3045 0.0582691952462677 4587 3977136 SGTC_1882 5615643 20 µM -1.57067115678249 0.0859635211022465 no 3046 0.0581295261085683 4508 2253075 SGTC_520 3584-0023 682 µM -1.57233695402284 0.0857167360907417 no 3047 0.0579362135700913 4526 1340790 SGTC_618 k072-0232 33.2 µM -1.57368004365514 0.0855181461726355 no 3048 0.0577807188706953 4564 5872756 YGL099W LSG1 SGTC_3002 9075603 71.4286 µM -1.57603140931289 0.0851713020060345 no 3049 0.0575092824056369 4483 20105405 SGTC_1106 tegaserod maleate 11.7 µM -1.58206337025956 0.0842863640554637 no 3050 0.0568175523154026 4564 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3091 9116372 49.47 µM -1.58285963613546 0.0841700628188835 no 3051 0.0567267302336628 4573 17169793 SGTC_3302 9125395 16.351 µM -1.58760466489805 0.0834795085618352 no 3052 0.0561878813467718 4498 17599668 SGTC_2748 diazoxide 86.69 µM -1.58823059117607 0.0833887349585854 no 3053 0.0561171030159266 4624 3019 A potassium channel activatior. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.58906520860351 0.0832678118201232 no 3054 0.0560228357610446 4573 688664 SGTC_2184 6075246 200 µM -1.59535853072311 0.0823602484434237 no 3055 0.0553160419031546 4527 2267320 SGTC_2924 9010168 62.78 µM -1.59646015712044 0.0822021512576377 no 3056 0.0551930472187949 4543 2993929 SGTC_1259 0671-0132 43 µM -1.5969292426579 0.0821349010395762 no 3057 0.0551407402487249 4484 X1259 SGTC_3193 9111931 49.47 µM -1.59888710438569 0.0818546605859766 no 3058 0.0549228449533692 4537 17087244 SGTC_2355 9061122 103.12 µM -1.60142353391095 0.0814926785540903 no 3059 0.0546415718670671 4554 5302957 SGTC_1208 2323-2347 50.3 µM -1.60166046345533 0.08145892732223 no 3060 0.0546153562344002 4568 5412760 SGTC_3185 9108267 49.47 µM -1.61590043216428 0.0794497079422428 no 3061 0.0530579210914256 4538 4910486 SGTC_321 4534-3890 65.3 µM -1.61869721364242 0.0790595344221282 no 3062 0.0527562133470379 4558 699746 SGTC_300 r073-0011 5.04 µM -1.62964982755623 0.077545516930894 no 3063 0.0515877634658149 4559 2735780 SGTC_1269 0831-0796 3.05 µM -1.62978563403515 0.0775268831006309 no 3064 0.0515734055351339 4587 927758 SGTC_2950 9072895 21.46 µM -1.63105236149864 0.0773532408047793 no 3065 0.0514396357131005 4493 17332245 SGTC_2537 larixol 68.93 µM -1.63283101514402 0.077109922784952 no 3066 0.0512522710426752 4526 6708759 SGTC_1205 4161-2785 76 µM -1.6340078785313 0.0769492490742063 no 3067 0.0511285981583375 4553 3498106 SGTC_1156 4092-0367 4.88 µM -1.63851954604629 0.0763356415525615 no 3068 0.0506566800256971 4600 1357585 SGTC_154 3389-1638 511.116 µM -1.64236829448171 0.0758151429799277 no 3069 0.050256850737911 4562 5238686 SGTC_1335 1486-0900 202 µM -1.64339824816053 0.0756763132039112 no 3070 0.0501502811767377 4566 X1335 SGTC_2516 gossypol 71.55 µM -1.64574732148429 0.0753604009767947 no 3071 0.0499078959672199 4578 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_707 0865-0008 204 µM -1.64764761601201 0.0751055785127207 no 3072 0.0497125016580331 4622 723043 SGTC_228 caffeine 993.056 µM -1.65020516097929 0.0747636591221239 no 3073 0.0494504908124831 4565 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2768 sulfasalazine 50.2 µM -1.66720183240089 0.0725214698828187 no 3074 0.0477371392543492 4551 5384001 An antioxidant and salicylic acid derivative. SGTC_596 1155-0152 116 µM -1.66742716818595 0.0724920935873558 no 3075 0.0477147476895416 4589 280313 SGTC_1711 st032263 62.8 µM -1.67028476343328 0.0721203485169586 no 3076 0.0474315181438563 4578 3958979 SGTC_1997 st073024 93.8 µM -1.67432159773111 0.0715976885690765 no 3077 0.047033706038413 4626 686268 SGTC_930 2810-3379 265 µM -1.67743069771759 0.071197129779678 no 3078 0.0467291453617485 4561 1015764 SGTC_2258 7960471 200 µM -1.67777322713355 0.0711531056631528 no 3079 0.0466956889033692 4581 2974708 SGTC_2148 5546263 113.568 µM -1.68093263345058 0.070748023146899 no 3080 0.0463880002191832 4614 792097 SGTC_2081 5214970 32.255 µM -1.6814400250968 0.0706831335216216 no 3081 0.0463387383206673 4522 2063512 SGTC_3252 9135871 49.47 µM -1.68378360885716 0.0703840091520396 no 3082 0.0461117480443784 4595 17682838 SGTC_123 0083-0120 66.675 µM -1.68383739709336 0.0703771553095838 no 3083 0.0461065488309654 4559 16001701 SGTC_161 4065-0411 162.148 µM -1.68549445923161 0.0701662592999005 no 3084 0.0459466064630988 4567 1906281 YLR208W SEC13 SGTC_112 phenothiazine 287.218 µM -1.68742490358523 0.0699211830513338 no 3085 0.0457608392931588 4544 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_69 0096-0274 206.684 µM -1.69688344825173 0.0687298996090362 no 3086 0.0448593489372546 4625 6741392 SGTC_3160 9100216 49.47 µM -1.6969412093736 0.0687226731041225 no 3087 0.0448538879933097 4587 17191039 SGTC_3337 9144342 33.5465 µM -1.69789099462898 0.068603929301423 no 3088 0.0447641686188115 4591 17682949 SGTC_2254 7938975 95.19 µM -1.69869918234511 0.0685030129405222 no 3089 0.0446879387955301 4621 2969277 SGTC_1655 st012546 55.1 µM -1.69938461452125 0.068417514533222 no 3090 0.0446233694758259 4583 720985 YLR208W SEC13 SGTC_886 0866-0150 153 µM -1.70082774145121 0.0682377731119872 no 3091 0.0444876691944872 4604 271463 SGTC_3149 9097855 49.47 µM -1.70349716929626 0.0679062567516589 no 3092 0.0442375336481994 4583 25236625 YMR079W SEC14 SGTC_2257 7960413 200 µM -1.70763171471661 0.0673952441862738 no 3093 0.043852349910833 4628 2974689 YIL048W NEO1 SGTC_2798 7813637 45.45 µM -1.71162457207764 0.0669045698498259 no 3094 0.0434829385086975 4583 956368 SGTC_2957 9076800 11.52 µM -1.71528066025028 0.0664577083903677 no 3095 0.0431468912971577 4577 16459615 SGTC_1726 st035556 14.5795 µM -1.71862124727348 0.0660514321420049 no 3096 0.0428416801234914 4622 5919439 SGTC_310 1273-0058 1.06 µM -1.72036056569538 0.0658406624703168 no 3097 0.042683460224908 4286 2734232 SGTC_2958 9077254 16.72 µM -1.73099586157519 0.0645632026923555 no 3098 0.0417262512916155 4597 16457351 SGTC_1255 0566-0045 221 µM -1.73566649914821 0.0640083092238128 no 3099 0.0413114101461511 4604 2788469 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.73630389537373 0.0639328720134683 no 3100 0.0412550574165964 4540 17037758 SGTC_1332 1480-0653 17.5 µM -1.73899645904248 0.0636149640212015 no 3101 0.0410176928860346 4615 5749438 SGTC_3326 9140064 16.379 µM -1.7402882535545 0.0634628805505642 no 3102 0.0409042077953091 4562 1868434 SGTC_96 0929-0093 37.281 µM -1.74366147928656 0.0630670835652813 no 3103 0.0406090680462489 4617 6991579 SGTC_1602 st001878 87.6 µM -1.74439035765865 0.0629818138461573 no 3104 0.0405455226097277 4576 595405 YLR310C CDC25 SGTC_3243 9134147 49.47 µM -1.74474124241158 0.062940796722718 no 3105 0.0405149603962486 4688 24282180 SGTC_3340 9146634 11.102 µM -1.74481957791716 0.062931642435392 no 3106 0.0405081398941997 4593 4907387 SGTC_2519 cryptotanshinone 88.04 µM -1.75204696907997 0.0620915032537145 no 3107 0.0398828659259511 4618 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2331 7980721 200 µM -1.75310192468484 0.0619696065319728 no 3108 0.0397922566192038 4567 2981221 SGTC_1501 4491-0275 38.4 µM -1.76211090341484 0.0609362410869508 no 3109 0.039025280723515 4626 5104718 SGTC_3139 9095020 49.47 µM -1.76246091548046 0.0608963668533062 no 3110 0.0389957271906764 4518 25236292 SGTC_2426 5582046 32.21 µM -1.76524226002627 0.0605802340109039 no 3111 0.0387615294802871 4585 2251934 SGTC_1524 corynanthine 62.1 µM -1.76535174714937 0.0605678158131224 no 3112 0.0387523338200679 4654 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1713 st033146 12.748 µM -1.76997220544375 0.0600455694020568 no 3113 0.0383658855169642 4582 674619 SGTC_1101 ebselen 5.29 µM -1.77054862302603 0.0599806655587661 no 3114 0.0383178959853138 4633 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2635 hydroquinidine 100 µM -1.77277196418481 0.0597308348759096 no 3115 0.0381332504098491 4560 442912 An experimental heart treatment. SGTC_447 ml7 120 µM -1.774094026216 0.0595826654132633 no 3116 0.0380237993759407 4655 4216 Selective myosin light chain kinase inhibitor. SGTC_670 4204-0025 119 µM -1.78859651282973 0.0579761548459186 no 3117 0.0368399099382588 4638 719039 SGTC_2301 7769476 200 µM -1.79354816937257 0.0574354997102472 no 3118 0.0364426578303574 4618 977820 SGTC_1224 0823-0416 294 µM -1.79902022197553 0.0568426464280031 no 3119 0.0360077409812294 4640 3598164 SGTC_2073 5212005 126 µM -1.79960607789048 0.0567794602685212 no 3120 0.0359614303535874 4577 691789 SGTC_2992 9074591 71.4286 µM -1.802282781908 0.0564914739545747 no 3121 0.0357504630443089 4573 17741321 SGTC_916 4466-0038 42 nM -1.80966125125522 0.0557035829695317 no 3122 0.0351741675010297 4657 5722064 YGL116W CDC20 SGTC_1191 1487-1166 10.6 µM -1.81460387521973 0.0551806656913478 no 3123 0.03479240327291 4642 3955771 SGTC_340 k038-0059 454 µM -1.81480445498667 0.0551595270064869 no 3124 0.0347769827716463 4622 23733424 SGTC_1616 st002734 56.1 µM -1.81572983530417 0.05506208591957 no 3125 0.0347059125126104 4620 4026101 SGTC_2080 5212524 12.4 µM -1.81640769516065 0.0549907946843268 no 3126 0.0346539278255306 4596 260183 SGTC_396 dithiazanine 1.25 µM -1.82560611590726 0.0540305804030862 no 3127 0.0339548069544728 4604 10578 An antihelmenthic. SGTC_1620 st003704 16.5 µM -1.82726929595004 0.0538583879538044 no 3128 0.0338296446755908 4650 2834414 SGTC_2854 9024559 71.43 µM -1.83025375076885 0.0535504909177495 no 3129 0.0336060018275375 4616 3163529 SGTC_819 1013-0258 27.7 µM -1.83091051242973 0.0534829223987342 no 3130 0.033556950501374 4639 5753198 SGTC_2998 9066762 71.4286 µM -1.83535521492591 0.0530274193831513 no 3131 0.033226537438476 4630 4945196 SGTC_2713 st079149 53.4 µM -1.83762060642901 0.0527964435137847 no 3132 0.0330591650965135 4658 3103253 SGTC_62 0180-0423 3.232 µM -1.8410618608274 0.0524471063940526 no 3133 0.0328062469536333 4591 30102 YGL099W LSG1 SGTC_2715 st079500 56.4 µM -1.84600859274156 0.0519481590500808 no 3134 0.0324454788916158 4648 28246688 SGTC_3221 9128209 49.47 µM -1.85154051589944 0.0513946621022423 no 3135 0.0320459158013625 4663 16460723 SGTC_430 0958-0115 16.4 µM -1.85999234759897 0.0505580827156499 no 3136 0.0314433043184649 4583 6833180 SGTC_2949 9072542 2.23 µM -1.86394503634398 0.0501705783154664 no 3137 0.0311647116656862 4608 16457352 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.8657344186297 0.0499959353499602 no 3138 0.0310392658471881 4597 6708739 YPR165W RHO1 SGTC_894 0960-0238 55.9 µM -1.87115337495022 0.0494700031035461 no 3139 0.0306619126044606 4642 6741907 YDL195W SEC31 SGTC_1350 1495-0454 146 µM -1.87695664598958 0.0489116783076624 no 3140 0.0302620180451668 4669 1069057 SGTC_587 k089-0003 57 µM -1.87792870185276 0.0488186523589954 no 3141 0.0301954596726745 4597 9659696 SGTC_225 nsc-122657 1.016 µM -1.87811450528303 0.0488008870387675 no 3142 0.0301827512091966 4654 275685 SGTC_2340 7987427 183.45 µM -1.88049484257004 0.0485737513900246 no 3143 0.0300203343054138 4627 2239331 SGTC_193 1273-0060 1.558 µM -1.8814310286487 0.0484846509094388 no 3144 0.02995665465603 4542 2847393 YHR072W ERG7 SGTC_570 0987-0065 62.6 µM -1.88408123705208 0.0482331287704716 no 3145 0.0297769938895086 4568 3104428 SGTC_2897 9048598 12.99 µM -1.88641679063549 0.0480123357671355 no 3146 0.0296194058397871 4634 6467404 SGTC_3155 9099265 49.47 µM -1.88937153652228 0.0477341669064251 no 3147 0.0294210310448872 4643 25236499 SGTC_1552 6-methylflavone 10.6 µM -1.89004581487769 0.0476708694737702 no 3148 0.0293759164822106 4616 689013 SGTC_3042 9091578 49.47 µM -1.89460036388823 0.0472450729181589 no 3149 0.0290726832795422 4651 25236497 SGTC_1427 4048-4900 550 nM -1.89643419424286 0.0470744945269741 no 3150 0.028951326948708 4647 24132586 SGTC_1779 st039427 55 µM -1.90020026242439 0.046725732523371 no 3151 0.0287034219335758 4643 1124498 SGTC_2232 chlorophetanol 41.5365 µM -1.90179821861946 0.0465783793389901 no 3152 0.0285987696361308 4718 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2906 7926292 26.41 µM -1.90877591147918 0.0459393058146473 no 3153 0.0281455027939844 4635 2966319 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.91292301712421 0.0455628305177712 no 3154 0.0278789542277934 4661 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2804 7954240 19.48 µM -1.92314574851687 0.0446453972096165 no 3155 0.0272308741457489 4649 828705 SGTC_74 000s-0487 160.283 µM -1.92502648812489 0.0444782428873214 no 3156 0.0271130222687039 4561 677548 SGTC_3308 9128332 17.569 µM -1.92793548720162 0.0442206935027468 no 3157 0.0269315755107631 4625 17332805 YDL196W YDL196W SGTC_1928 4'-methoxychalcone 40.3 µM -1.92918209084817 0.0441106935400096 no 3158 0.0268541303416169 4654 641818 SGTC_906 1165-0455 526 µM -1.93720468289416 0.0434080504907179 no 3159 0.0263601640307606 4647 3252859 SGTC_2443 5493264 126.67 µM -1.93871069202837 0.0432771623947331 no 3160 0.0262682879977083 4674 5340055 SGTC_1921 5740136 50 µM -1.94030059372893 0.0431393291659675 no 3161 0.0261715846367846 4593 1774243 SGTC_2916 7875993 68.79 µM -1.94081728792639 0.0430946118524999 no 3162 0.0261402216572582 4584 1299250 SGTC_1555 citronellol 128 µM -1.94160739565482 0.0430263043722464 no 3163 0.0260923234459219 4662 8842 A terpine precursor. SGTC_2261 9010538 184.68 µM -1.96512762279586 0.0410326476148239 no 3164 0.0246997341294328 4649 6457250 SGTC_2359 9039622 200 µM -1.96725070113718 0.0408564364846419 no 3165 0.0245771577358151 4643 6463596 SGTC_602 3130-1533 38.1 µM -1.97026971858321 0.0406069219530424 no 3166 0.0244037334891342 4689 720941 SGTC_119 0121-0043 24.815 µM -1.97536455723381 0.0401886517222832 no 3167 0.0241133959593988 4669 1092378 SGTC_3181 9108277 49.47 µM -1.97930788610645 0.0398673252128592 no 3168 0.0238906761274821 4675 17097298 SGTC_1604 st002052 72.4 µM -1.98464787396421 0.03943552242178 no 3169 0.0235918310075629 4715 6254834 YHR062C RPP1 SGTC_448 monastrol 171 µM -1.98614550078482 0.0393151066556519 no 3170 0.0235085851179836 4611 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_689 0833-0039 98 µM -1.98810135330293 0.0391582982257277 no 3171 0.0234002408712527 4645 5374726 SGTC_2725 haloperidol 53.21 µM -1.99518579879391 0.03859456675875 no 3172 0.023011309662188 4661 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_341 1486-1430 230 µM -1.99644746866982 0.038494868870169 no 3173 0.0229426191511636 4659 2054753 YPL210C SRP72 SGTC_1392 3455-1037 33.9 µM -2.0031946586303 0.0379652590610269 no 3174 0.0225781993847222 4696 981132 SGTC_1320 1313-0481 95.3 µM -2.01069996118654 0.0373831423474501 no 3175 0.0221785790719959 4652 6813365 YLR208W SEC13 SGTC_405 ebelactone b 50 µM -2.01316232527226 0.0371937554849974 no 3176 0.0220487776249926 4675 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1568 digitonin 820 nM -2.01369265721107 0.0371530690492907 no 3177 0.0220209057119304 4658 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_23 0213-0011 39.996 µM -2.01618349629248 0.0369624611371699 no 3178 0.0218903957651443 4678 627608 SGTC_3083 9117465 49.47 µM -2.02091594995687 0.0366025193009284 no 3179 0.0216442332531705 4645 16420915 SGTC_696 1560-0013 611 µM -2.02370171709822 0.0363919830872183 no 3180 0.0215004259075871 4690 1650269 SGTC_1565 sinapyl alcohol 95.1 µM -2.02420632103379 0.0363539535352387 no 3181 0.0214744637396362 4679 5280507 A phenol propionate derived from cinnamic acid. SGTC_2721 ifenprodil 61.44 µM -2.02881657857473 0.0360080048332895 no 3182 0.0212384880262884 4663 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1138 3761-0006 1.03 µM -2.0312463893955 0.0358267623383381 no 3183 0.0211150033581973 4703 12061087 SGTC_1795 st049545 62.3 µM -2.03188400777748 0.0357793256296109 no 3184 0.0210826999449244 4665 5291882 SGTC_331 k048-0133 24.5 µM -2.03204480488351 0.0357673709839259 no 3185 0.0210745601486244 4689 6813582 SGTC_616 4092-0450 108 µM -2.03487307424978 0.0355576346167417 no 3186 0.0209318229518832 4704 787165 SGTC_1131 3454-3128 32.3 µM -2.03675868915916 0.0354183637875495 no 3187 0.0208371149930632 4647 710982 SGTC_1298 1079-1278 263 µM -2.03702876991639 0.0353984523940702 no 3188 0.0208235795120789 4674 2840950 SGTC_473 2-arachidonoylglycerol 10 µM -2.03932631059513 0.0352294397780791 no 3189 0.0207087357197451 4579 5282280 An endocannabinoid. SGTC_1410 3909-8106 77.9 µM -2.04284535393502 0.0349718544321495 no 3190 0.0205338746334158 4732 1039210 SGTC_706 4262-0057 46.9 µM -2.04305019574685 0.0349569082480805 no 3191 0.020523734697293 4696 883298 SGTC_715 0868-0130 184 µM -2.04831454789214 0.0345745926200934 no 3192 0.0202645942120124 4731 2876258 SGTC_2766 oltipraz 83.91 µM -2.05260624730425 0.034265461757148 no 3193 0.0200553905845418 4678 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3238 9133470 49.47 µM -2.05887443099569 0.0338180501868356 no 3194 0.0197531345404143 4711 3534688 SGTC_1976 st070609 63.5 µM -2.05901909391575 0.0338077814224423 no 3195 0.0197462046989851 4671 682556 SGTC_2981 9013952 38.96 µM -2.06085736725941 0.0336775165508672 no 3196 0.0196583247931153 4629 2996344 SGTC_1619 st003326 88.7 µM -2.06153234364298 0.0336297897478676 no 3197 0.0196261405459187 4677 2849032 SGTC_2852 9023854 51.95 µM -2.07010615742346 0.0330283753895275 no 3198 0.0192212022032971 4695 19798528 SGTC_5 0352-0601 109.883 µM -2.07078739728401 0.0329809719845896 no 3199 0.019189334244975 4612 762456 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.07517327006326 0.0326771261102271 no 3200 0.0189852395045104 4664 364106 SGTC_1359 1582-0056 520 nM -2.07551563132751 0.032653505343788 no 3201 0.0189693858396325 4735 3661189 SGTC_963 1269-2853 151 µM -2.0817214807058 0.0322277762123091 no 3202 0.0186839586927985 4689 3668223 SGTC_1889 st059080 5.18 µM -2.08295936514229 0.0321434062129252 no 3203 0.0186274638156962 4682 176925 Isolated from Daphnopsis sellowiana. SGTC_953 1188-0045 9.7 µM -2.09443133768412 0.0313701578235614 no 3204 0.0181107868060032 4668 6144426 SGTC_2436 5633522 8.09 µM -2.09667548204489 0.0312207083392241 no 3205 0.0180111561679653 4684 5724242 SGTC_332 4112-0506 40.9 µM -2.10401257451408 0.0307361971649817 no 3206 0.0176886750705134 4712 2790355 SGTC_1700 st030840 7.9285 µM -2.10903637374616 0.0304080501126704 no 3207 0.0174707210452728 4734 5499307 SGTC_3323 9138564 53.9225 µM -2.11271275379706 0.0301697581861823 no 3208 0.0173126805078376 4719 43912313 YNL103W MET4 SGTC_2963 9082507 9 µM -2.11558244518627 0.0299848309451872 no 3209 0.0171901680900931 4677 16459611 SGTC_1379 2144-0755 36.5 µM -2.11713500293209 0.0298851742631736 no 3210 0.0171241958730016 4714 5392327 SGTC_110 0850-0284 111.64 µM -2.11908682452354 0.0297602792920537 no 3211 0.0170415649927362 4693 3906265 SGTC_1951 sophoraflavanone G 9.2 µM -2.12169464956903 0.0295940834902722 no 3212 0.0169316941130173 4661 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1420 4'-methoxyflavone 42 µM -2.13052296461306 0.029037166081996 no 3213 0.0165642309699147 4724 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1558 st069300 45.6 µM -2.14639686300956 0.0280577022242038 no 3214 0.0159206646987504 4714 24208000 SGTC_299 1273-0059 1.44 µM -2.14675608426312 0.0280358595876744 no 3215 0.0159063526076511 4489 2848077 SGTC_2342 7990637 118.86 µM -2.15722772543751 0.0274053222875561 no 3216 0.0154939626011245 4696 2033102 YER133W GLC7 SGTC_2179 6298986 200 µM -2.16670662373227 0.0268448016633234 no 3217 0.0151286156093433 4692 738374 SGTC_2913 7966556 36.57 µM -2.17530278477134 0.0263447880497346 no 3218 0.0148037169948118 4631 2976516 SGTC_1714 st033236 13.627 µM -2.17547652713604 0.0263347627725987 no 3219 0.0147972126204248 4704 2916566 SGTC_53 0973-0023 39.979 µM -2.18411666616565 0.0258402171183375 no 3220 0.0144768381641679 4663 674768 SGTC_2185 6113692 200 µM -2.18566564502203 0.0257523830949851 no 3221 0.0144200380489822 4707 874150 SGTC_2233 sulbentine 40.3845 µM -2.19376057431043 0.0252974198420318 no 3222 0.0141263132686936 4728 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1247 0448-0043 5.84 µM -2.19878147935492 0.0250186257555499 no 3223 0.0139467320180004 4694 3089013 YGL099W LSG1 SGTC_1409 3909-8004 61.9 µM -2.20738559465058 0.0245468579765185 no 3224 0.0136435659578888 4756 2119279 SGTC_1084 voriconazole 435 nM -2.2085108926292 0.0244857130004401 no 3225 0.0136043396713351 4749 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2749 bexarotene 57.39 µM -2.21072158672551 0.0243659634203798 no 3226 0.0135275613665874 4700 82146 An retinoic acid receptor inhibitor. SGTC_898 1000-0849 28.3 µM -2.21456277412462 0.0241590622210287 no 3227 0.0133950447601935 4725 6751807 SGTC_2118 5526350 200 µM -2.2155053384299 0.0241085181676595 no 3228 0.013362699165943 4729 743594 SGTC_674 0498-0004 451 µM -2.22187704110269 0.0237691670215208 no 3229 0.0131458081898644 4714 4231473 SGTC_1270 0831-1170 17.3 µM -2.22844389930152 0.0234236334992954 no 3230 0.0129254642253427 4748 6764716 SGTC_3016 9080866 49.47 µM -2.22939265688084 0.0233740631295707 no 3231 0.0128938951949918 4728 17066299 SGTC_423 5-fluorouracil 457 µM -2.23473804931723 0.0230964257881384 no 3232 0.0127172755398633 4680 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_255 tunicamycin 200.472 nM -2.2358607916408 0.0230384652934977 no 3233 0.0126804456624545 4685 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1389 3405-0187 19 µM -2.23668613259052 0.0229959360225008 no 3234 0.0126534304898894 4716 799890 SGTC_222 nsc-310342 10.666 µM -2.24179367826485 0.0227342158271104 no 3235 0.0124873550035012 4755 432556 SGTC_156 3474-0145 5.642 µM -2.24268470479281 0.0226888161035001 no 3236 0.0124585768222582 4676 2265471 SGTC_339 3091-4833 71.4 µM -2.25508011717872 0.022065128283199 no 3237 0.012064150205518 4557 3240077 SGTC_3017 9080681 49.47 µM -2.26135831362814 0.0217547955797798 no 3238 0.0118685389663738 4732 16451914 SGTC_127 0180-0333 59.125 µM -2.27006210514712 0.0213306702002462 no 3239 0.01160190757339 4681 771601 SGTC_995 3931-2021 34.6 µM -2.27549931269021 0.0210692860516378 no 3240 0.011437996931756 4719 730143 SGTC_1189 1431-2119 7.28 µM -2.27650649620305 0.021021166192446 no 3241 0.0114078561193801 4733 3107275 SGTC_428 3448-4153 16.5 µM -2.2777034653645 0.0209640999783537 no 3242 0.0113721255677089 4717 3834874 SGTC_2655 perillic acid 100 µM -2.2786492471606 0.0209191020489706 no 3243 0.0113439619849804 4758 5702197 An apoptosis inducer. SGTC_1774 st048371 48.465 µM -2.29234899138672 0.020276417452263 no 3244 0.0109427564610588 4737 4242727 SGTC_41 0478-0632 82.643 µM -2.29778850234799 0.0200259215776085 no 3245 0.0107869147389526 4711 3750424 SGTC_1369 1866-0067 208 µM -2.31610668782919 0.0192015672388196 no 3246 0.0102762221217297 4721 3531355 SGTC_3054 9094397 49.47 µM -2.32530796699298 0.0187984926635974 no 3247 0.0100277492973357 4720 2598354 SGTC_2483 5729050 27.16 µM -2.34055777381488 0.0181463099682376 no 3248 0.00962747952947825 4721 2865180 SGTC_2896 9052656 71.43 µM -2.36050521786284 0.0173224167042941 no 3249 0.00912503078958841 4409 6469436 SGTC_2350 9023895 38.85 µM -2.36644118548677 0.0170834971280221 no 3250 0.00898001382353163 4715 2997209 SGTC_2567 aureobasidin a 60 nM -2.36664611917666 0.0170752992016244 no 3251 0.00897504350708973 4748 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1164 k060-0068 93.7 µM -2.3753621837972 0.0167297311063123 no 3252 0.00876586900057156 4749 5963676 SGTC_2750 bromebric acid 70.15 µM -2.38469845817421 0.0163662274040293 no 3253 0.00854656282702699 4740 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2147 5545932 89.7195 µM -2.38613204670035 0.0163110146391856 no 3254 0.00851331814072692 4767 797404 SGTC_57 miconazole 162.5 nM -2.38770189092401 0.016250737232473 no 3255 0.00847704392008007 4631 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1653 st012112 65 µM -2.39256107511368 0.0160653667744953 no 3256 0.00836562159737185 4749 720429 SGTC_1447 4239-0816 81.9 µM -2.40279994158031 0.0156806947100886 no 3257 0.00813504283739947 4765 1341554 SGTC_3044 9093193 49.47 µM -2.41580916898662 0.0152033613663753 no 3258 0.00785014367178064 4723 25236277 SGTC_874 0599-0792 117 µM -2.4268817783218 0.0148069724240769 no 3259 0.00761460877897356 4748 765305 SGTC_3327 9140648 26.9345 µM -2.43375312277006 0.0145654806551905 no 3260 0.00747159160389034 4760 8029710 SGTC_975 1335-0046 28.5 µM -2.4847160067036 0.0128779319728633 no 3261 0.00648274111037246 4757 16486740 SGTC_1686 st019653 115.5 µM -2.48828062851131 0.0127664955380063 no 3262 0.00641812004083812 4778 97252 SGTC_83 0170-0301 39.027 µM -2.50460660939502 0.0122667127510204 no 3263 0.0061293827521995 4776 3089716 SGTC_2186 6124449 200 µM -2.50491649792021 0.0122573925313579 no 3264 0.0061240152701622 4768 3834182 YLR033W RSC58 SGTC_978 1416-0512 87.4 µM -2.50698003707571 0.0121954857778251 no 3265 0.00608837943033468 4762 6814003 SGTC_102 gallobenzophenone 83.616 µM -2.5296838622208 0.0115320593577862 no 3266 0.00570826703430175 4756 70837 SGTC_1175 0741-0056 27.6 µM -2.54400434164724 0.0111299165810054 no 3267 0.00547948612156393 4775 765927 SGTC_1790 st045711 43.5 µM -2.55161195951248 0.0109212841154347 no 3268 0.00536129335602037 4766 585119 SGTC_845 0330-0138 4.51 µM -2.55738827689394 0.0107651544351462 no 3269 0.00527307144566007 4746 9039800 SGTC_699 0375-0592 111 µM -2.55947914976806 0.0107091205870862 no 3270 0.00524145719955566 4788 762578 SGTC_361 000s-0510 1.45 µM -2.56297748039535 0.010615935781094 no 3271 0.0051889389756686 4707 660 SGTC_186 3455-3465 67.277 µM -2.5805632967664 0.0101581262157628 no 3272 0.00493196358910555 4791 755278 SGTC_1609 st001574 46.4 µM -2.58237248157413 0.0101120196606903 no 3273 0.00490618083950463 4768 3960012 SGTC_2756 carbadox 75.1 µM -2.5884819916042 0.00995766731829439 no 3274 0.00481999937142098 4708 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2938 9059746 27.26 µM -2.59079510394913 0.00989976725460952 no 3275 0.00478772420584113 4748 6471769 SGTC_2182 6325192 200 µM -2.59674407054646 0.00975220552537289 no 3276 0.00470560085634319 4776 736248 SGTC_120 rhodamine 6G 52.259 µM -2.60128676887151 0.00964082309434211 no 3277 0.00464373909138679 4763 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1177 0983-0204 23.6 µM -2.64021904990555 0.00873096677068447 no 3278 0.004142622820929 4780 766818 SGTC_775 4577-0580 57.3 µM -2.6601051446116 0.00829596091497089 no 3279 0.0039058130537026 4769 2006902 SGTC_1452 4194-0072 190 µM -2.67072243263965 0.00807159584189237 no 3280 0.00378441028267544 4789 1343545 SGTC_1434 4073-0095 163 µM -2.68444702288396 0.0077894809076605 no 3281 0.00363249480306398 4793 24133745 SGTC_1787 fluconazole 80 µM -2.70965131181476 0.00729392477579395 no 3282 0.00336769876201296 4511 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2895 9054447 58.44 µM -2.7348345625978 0.00682675448726823 no 3283 0.00312058175156147 4782 2697450 SGTC_2939 9044578 71.43 µM -2.75844346305447 0.00641299981039233 no 3284 0.00290386752404768 4746 2653634 SGTC_1855 st056195 39.6 µM -2.79226951769239 0.00585887297102759 no 3285 0.00261698701583194 4752 4028379 SGTC_983 1491-0821 12.2 µM -2.79281055722941 0.00585036613490913 no 3286 0.00261261417017677 4779 46495113 SGTC_3100 9120536 49.47 µM -2.80202884467408 0.00570710004177296 no 3287 0.00253911664769223 4747 16421196 SGTC_2264 7948757 110.76 µM -2.8180082142041 0.00546612162846958 no 3288 0.00241612867942683 4764 2971411 SGTC_35 0133-0054 64.071 µM -2.84276115042458 0.00511066411783888 no 3289 0.00223622868410288 4750 99677 SGTC_882 0843-0131 351 µM -2.88855474237818 0.00450692338817572 no 3290 0.00193508328712184 4790 5425421 SGTC_2570 licareol 100 µM -2.89498132675403 0.00442749980067124 no 3291 0.00189590544134319 4765 443158 SGTC_276 colchicine 750 µM -2.91279743562102 0.00421381562002107 no 3292 0.001791034410901 4798 2833 A microtubule depolymerizer. SGTC_375 3970-0961 9.27 µM -2.92186215660526 0.00410867506702516 no 3293 0.00173972747452466 4782 2898222 SGTC_1618 st003135 44.5 µM -2.93419903838951 0.00396935406937088 no 3294 0.00167204843815649 4783 1270615 SGTC_217 ketoconazole 989 nM -2.96667571273728 0.00362260544595917 no 3295 0.00150519145006729 4702 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_780 0109-0199 192 µM -2.99746758068097 0.00331920944658324 no 3296 0.00136116405942029 4790 610414 SGTC_182 3448-4371 550.524 µM -3.00978523776938 0.00320438210061304 no 3297 0.00130716236507097 4767 3491403 SGTC_2287 7945887 168.79 µM -3.01899445741945 0.00312088079077197 no 3298 0.00126807585632008 4787 1245853 SGTC_1590 st077108 57.8 µM -3.03671927766998 0.00296566025911221 no 3299 0.00119584040152007 4801 5489485 SGTC_1450 4112-4260 37.6 µM -3.09310011013674 0.00251709410533258 no 3300 0.000990386520035709 4780 1633175 SGTC_897 1000-0139 31.4 µM -3.0937240950257 0.00251249296098837 no 3301 0.000988306061042306 4781 6151020 SGTC_2425 5628681 7.85 µM -3.10543193587331 0.00242755976895359 no 3302 0.000950006717986013 4794 5714958 SGTC_2820 7989630 71.43 µM -3.11707876490709 0.00234565495420858 no 3303 0.000913263824465206 4797 2984098 SGTC_2763 lisinopril 49.32 µM -3.1323157743923 0.00224228165137526 no 3304 0.000867166158924551 4783 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_27 0485-0001 32.618 µM -3.1359506210875 0.00221823945213772 no 3305 0.000856490213840825 4803 2054479 SGTC_3103 9120822 49.47 µM -3.13887107129404 0.00219909205065633 no 3306 0.000848000254049473 4796 17141819 SGTC_389 tpck 16.7 µM -3.1653306379455 0.00203232225536268 no 3307 0.000774534066210676 4793 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2180 6301957 200 µM -3.1809443827188 0.00193938190796141 no 3308 0.000733979043623705 4797 845462 SGTC_3105 9121040 49.47 µM -3.20969258067971 0.00177829541970923 no 3309 0.000664385009056035 4796 41448907 SGTC_2823 7987624 58.44 µM -3.22477111644401 0.00169876242282345 no 3310 0.000630367097325687 4766 2239440 SGTC_2310 7668677 200 µM -3.24231721740776 0.00161029913547968 no 3311 0.000592809869101637 4772 2197143 SGTC_1516 st013856 110 µM -3.32813929474294 0.0012351081669447 no 3312 0.00043714070137596 4797 5281404 A mutagen and neurotoxin. SGTC_1142 3253-1408 9.78 µM -3.3554930083613 0.00113351969374027 no 3313 0.000396118295229439 4787 256655 SGTC_208 k072-0098 12.366 µM -3.39209010181247 0.00100956475431085 no 3314 0.00034680813556245 4800 5948901 SGTC_590 k048-0076 22.4 µM -3.51716357783654 0.000673889474341594 yes 3315 0.000218092443486353 4804 6832814 SGTC_2534 helenine 20.12 µM -3.54048139261452 0.000624070997023678 yes 3316 0.000199698898839885 4797 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1114 scopoletin 1.73284 µM -3.5583381074666 0.000588244131892686 yes 3317 0.000186604354699748 4807 5280460 A coumarin with genotoxic properties. SGTC_589 1227-0070 34.1 µM -3.5600131097632 0.000584982877708965 yes 3318 0.000185418140205214 4805 2841384 SGTC_2008 4012253 172 µM -3.61845626833649 0.000481128507215085 yes 3319 0.000148182782910527 4792 603940 SGTC_2010 4012422 159 µM -3.62906841825785 0.000464210401663928 yes 3320 0.000142222925986294 4787 952393 SGTC_2004 4023728 41.89 µM -3.67348556556422 0.000399209794384277 yes 3321 0.000119632099537387 4797 360084 YDR527W RBA50 SGTC_220 paclitaxel 373.376 µM -3.69215798692641 0.000374494501735543 yes 3322 0.000111179628990765 4791 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_49 0717-0965 32.132 µM -3.70810950573064 0.000354514111983654 yes 3323 0.000104406179595755 4807 5889349 YGL099W LSG1 SGTC_2416 tofa 880 nM -3.75061455894082 0.000306006119361868 yes 3324 8.82008438860348e-05 4790 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2317 5986382 200 µM -3.79892167420884 0.000258406115404349 yes 3325 7.26635036422437e-05 4803 877883 SGTC_51 1013-0126 23.419 µM -3.90888562842744 0.000174571702320657 yes 3326 4.63614228944607e-05 4802 1627850 SGTC_3322 9139058 2.11 µM -3.94269092139504 0.000154426199807192 yes 3327 4.02862317704632e-05 4808 4908926 YPR165W RHO1 SGTC_3207 9114163 49.47 µM -4.01971806288496 0.00011636315770111 yes 3328 2.9133914244099e-05 4792 849233 SGTC_3129 9127257 49.47 µM -4.09237464357465 8.86923413569415e-05 yes 3329 2.13489038033256e-05 4803 837894 SGTC_1433 4060-0023 7.6 µM -4.16405729147845 6.75513684761554e-05 yes 3330 1.56320805135546e-05 4808 3840627 SGTC_2620 irigenin 100 µM -4.42883603461865 2.37906835152649e-05 yes 3331 4.73715072092264e-06 4795 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_335 4077-0256 27.6 µM -4.43943725140906 2.27887742357584e-05 yes 3332 4.50972030861215e-06 4787 3121989 SGTC_3182 9108849 49.47 µM -4.4647208296148 2.0558315742756e-05 yes 3333 4.00866099651893e-06 4810 17133045 SGTC_70 0141-0289 43.283 µM -4.71107847148392 7.32324939307888e-06 yes 3334 1.23204663371539e-06 4804 352408 SGTC_2002 4023503 131 µM -4.78562839189671 5.30401250090443e-06 yes 3335 8.52265898322528e-07 4809 4736863 YCR052W RSC6 SGTC_2011 4012611 177 µM -5.05274831760025 1.60549771914848e-06 yes 3336 2.17748802396547e-07 4805 2049887 SGTC_2369 9071472 200 µM -6.17703830029695 5.3459415392239e-09 yes 3337 3.26576164159678e-10 4810 17296037 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -6.2345294177581 3.87736924444338e-09 yes 3338 2.26569086817033e-10 4810 803109 SGTC_2380 9035439 200 µM -6.46933387410595 1.01360977882743e-09 yes 3339 4.92179415962642e-11 4810 6462575