SGTCid condition conc unit GCD14|YJL125C.score GCD14|YJL125C.strain.pval GCD14|YJL125C.strain.significant GCD14|YJL125C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_458 nppb 133 µM 4.50163343886071 7.54714659326922e-08 yes 1 3.37166039254348e-06 1 4549 A chloride channel blocker. SGTC_454 lyso-paf C-16 6.67 µM 4.4414391883327 1.09956929517469e-07 yes 2 4.46796007524442e-06 3 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1445 4239-0156 97.7 µM 4.40101895641921 1.4119616169788e-07 yes 3 5.38718550936829e-06 2 4008346 SGTC_452 diindolylmethane 8 µM 4.22441612810859 4.1067649305366e-07 yes 4 1.19780523041031e-05 3 3071 Inhibits expression of several cancer promoting factors. SGTC_450 aminopyrene 156 nM 4.18973682899965 5.04064400580246e-07 yes 5 1.3963908329834e-05 6 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1119 parthenolide 318.541 nM 4.12484364727506 7.36513888929539e-07 yes 6 1.85493346264913e-05 9 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_446 go6976 132 µM 3.98846611518363 1.60538395093122e-06 yes 7 3.32509497731572e-05 2 3501 A protein kinase C inhibitor. SGTC_1203 3992-3522 103 µM 3.73002655188768 6.57995442979202e-06 yes 8 9.57297965478774e-05 14 5322312 SGTC_1231 0242-0792 125 µM 3.52300882773993 1.91435519608085e-05 yes 9 0.000213338574196715 4 3707635 SGTC_734 2023-0417 80 µM 3.50302730622542 2.11604158480687e-05 yes 10 0.000230001152084476 12 3935732 SGTC_1510 1123-0200 71.5 µM 3.07724316458279 0.000158424336541622 yes 11 0.00104462396740976 29 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_969 1313-0238 134 µM 2.99957506638157 0.000223098889904349 yes 12 0.00135178247384449 43 5212874 SGTC_763 3453-1109 128 µM 2.97386706099265 0.000249446631261151 yes 13 0.00147036224648753 17 1560353 SGTC_530 4358-1714 28 µM 2.87983836400578 0.000372568296557024 yes 14 0.00198939548618796 22 1564641 SGTC_1522 st012842 45.6 µM 2.86758266798702 0.000392245178704229 yes 15 0.00206810365249902 28 3491067 YOR116C RPO31 SGTC_1096 rimcazole 32.2 µM 2.85461877719471 0.000414105866721113 yes 16 0.00215442580472281 9 18528119 A dopamine reuptake inhibitor. SGTC_1886 st057356 49.9 µM 2.82284413066958 0.000472555531629857 yes 17 0.00237998535441039 22 24207747 SGTC_1373 2887-0003 58.5 µM 2.80202635221644 0.000514898666757856 yes 18 0.00253913626489044 36 776948 SGTC_604 1000-0114 314 µM 2.78613845885226 0.000549547950331599 yes 19 0.00266700413779795 10 1572745 SGTC_2782 7736369 71.43 µM 2.74943549873992 0.000637995363817092 yes 20 0.00298490054876846 30 2950836 YOL077C BRX1 SGTC_644 1498-1197 63.3 µM 2.7198105407178 0.000718777776749613 yes 21 0.00326596647955501 23 6741615 SGTC_1370 2001-0092 44.6 µM 2.70611823817528 0.000759213166894829 yes 22 0.00340374016186464 21 790957 SGTC_1985 st071382 65.5 µM 2.68175470332522 0.000836382543470227 yes 23 0.00366185695831513 19 6123237 SGTC_769 0302-0231 76 µM 2.65993069696006 0.000911569258767308 yes 24 0.00390783657358392 47 571869 YER009W NTF2 SGTC_2757 clomiphene 4.22 µM 2.61879563398693 0.00107041017745555 no 25 0.0044120397056615 44 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_282 k297-0036 65.7 µM 2.54405325125625 0.00142545754703584 no 26 0.00547871892014875 22 5061378 SGTC_1610 st001799 48.1 µM 2.52414303612981 0.00153667834900688 no 27 0.00579903636385882 16 621897 SGTC_148 3253-0744 288.01 µM 2.51378944326785 0.00159759085059951 no 28 0.00597208605019886 34 6893655 SGTC_2443 5493264 126.67 µM 2.49982938055874 0.00168320529386438 no 29 0.00621265663252161 23 5340055 SGTC_633 0437-0093 97.7 µM 2.49038267215524 0.00174348828586492 no 30 0.00638028098830301 29 2831118 SGTC_97 0535-0701 19.132 µM 2.45650199238854 0.00197620208782179 no 31 0.00701485120914391 36 2832013 YGL099W LSG1 SGTC_1907 st060210 83.7 µM 2.44460878802649 0.00206435746046447 no 32 0.00725046702020596 31 688793 SGTC_1033 k072-0102 21.3 µM 2.43375376631914 0.00214791635786622 no 33 0.00747157832093253 29 5965931 SGTC_1061 3448-9325 110 µM 2.43087646251254 0.00217057334438713 no 34 0.00753117463401392 31 723482 SGTC_155 k072-0202 43.6 µM 2.40673257254833 0.00236939796612699 no 35 0.00804797582220539 28 5857737 SGTC_662 k832-1615 104 µM 2.38457364703326 0.00256623234303534 no 36 0.0085494625599596 29 5878478 SGTC_2069 5228469 200 µM 2.38267442467094 0.00258377198913857 no 37 0.00859369374997408 31 2835210 SGTC_767 0929-0023 86 µM 2.34013287863597 0.00300613437590415 no 38 0.00963844000730766 50 1204563 SGTC_2937 9044753 11.33 µM 2.32085664413711 0.00321723426982259 no 39 0.0101472910851949 40 6465530 YGL099W LSG1 SGTC_2837 9008476 45.46 µM 2.31312857318376 0.00330554677087093 no 40 0.0103577855843198 29 2992805 SGTC_599 1935-0052 86.5 µM 2.30872311777072 0.00335685994729374 no 41 0.0104794753331794 26 9557311 SGTC_1521 st012942 49.4 µM 2.30452445148074 0.00340642973902471 no 42 0.0105966106947178 32 24207259 SGTC_2491 paeonol 100 µM 2.2966685479075 0.00350094709571848 no 43 0.0108188424886247 19 11092 Increases levels of cortical cytochrome oxidase. SGTC_421 streptovitacin 30 mM 2.28132441682356 0.00369237778677068 no 44 0.0112646284581223 25 91467 include heat shock SGTC_1341 1486-1360 280 µM 2.26630638222699 0.00388877931375103 no 45 0.0117163154683827 33 3976547 SGTC_866 0495-0101 262 µM 2.26109979539686 0.00395902382542607 no 46 0.011876539028268 42 635694 SGTC_2447 5741742 33.78 µM 2.20169637293781 0.00484471048427967 no 47 0.0138433815564566 53 1776504 SGTC_876 0720-0963 56.8 µM 2.19786592070394 0.00490746213520261 no 48 0.0139793310463297 29 765861 SGTC_766 1391-0721 126 µM 2.19212302278047 0.00500290134183531 no 49 0.0141853123847778 41 1020919 YIL115C NUP159 SGTC_19 0279-0214 38.434 µM 2.16729244936338 0.00543484783205665 no 50 0.0151062809386347 28 3566274 YBR002C RER2 SGTC_1744 st037937 38.9 µM 2.15758863013941 0.00561246344513718 no 51 0.0154799147364517 38 1016152 SGTC_1340 1486-1359 257 µM 2.15501005963953 0.00566051942486062 no 52 0.0155805235134194 40 4309068 SGTC_2786 7743617 45.45 µM 2.14144247351012 0.00591944151354912 no 53 0.0161191864363002 34 583674 SGTC_2616 abietic acid 100 µM 2.13451369080058 0.0060556782319237 no 54 0.0164003770813821 41 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3096 9117468 49.47 µM 2.09611294919234 0.00686228926761426 no 55 0.0180360862875619 27 41316311 SGTC_130 0136-0219 337.655 µM 2.09597577394762 0.00686533306518083 no 56 0.0180421700282627 51 234244 SGTC_203 k066-0004 30.888 µM 2.08457133353587 0.00712259517443458 no 57 0.0185541144300434 52 6795412 SGTC_2627 acetyl isogambogic acid 100 µM 2.0748230569376 0.00734920117774185 no 58 0.0190014684222089 49 6857789 A caspase activator and apoptosis inducer. SGTC_1236 0330-0013 258 µM 2.06539791977346 0.00757431358483273 no 59 0.0194426826238392 32 4617066 SGTC_143 4032-1194 15.74 µM 2.06195730220237 0.0076579905981291 no 60 0.0196059006178461 81 1806963 SGTC_759 3486-0358 89.3 µM 2.0593278548553 0.00772248723160546 no 61 0.0197314209120945 50 875103 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.05765149709012 0.00776385504225675 no 62 0.0198117997309809 58 165521 SGTC_2439 5492030 7.2 µM 2.05664588466738 0.00778876420546837 no 63 0.0198601505540811 44 5722370 SGTC_285 1486-1325 46 µM 2.044071637351 0.00810621817941532 no 64 0.0204732353081057 62 22310230 SGTC_2946 9065502 71.43 µM 2.03568376702836 0.00832425262875364 no 65 0.0208910600829285 24 16489101 SGTC_1435 4092-0789 56.7 µM 2.0333460861034 0.00838592871805038 no 66 0.0210087850772161 53 2248285 SGTC_2221 6807166 181.081 µM 2.03279074581542 0.00840063934947031 no 67 0.0210368342452781 28 674925 SGTC_1671 st016596 74.5 µM 2.02350330243555 0.00865003721426699 no 68 0.0215106417225881 39 2829167 SGTC_2407 paclitaxel 400 µM 2.02213258950898 0.00868738992390113 no 69 0.0215813280210179 50 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_120 rhodamine 6G 52.259 µM 2.01984823258972 0.0087499542881748 no 70 0.0216995661749987 96 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2128 5255449 168.493 µM 2.00126454199835 0.00927377488707387 no 71 0.0226819443840602 56 736008 SGTC_2918 7977171 22.06 µM 1.99635411309615 0.00941668878211044 no 72 0.0229476958894429 50 2236483 SGTC_2524 avocatin b 10.57 µM 1.99408919265758 0.00948325400148758 no 73 0.0230711540469107 28 6710748 SGTC_765 1319-0117 244 µM 1.99211140214782 0.0095417167170666 no 74 0.0231794180968396 47 3487746 YGL099W LSG1 SGTC_1167 k781-0610 148 µM 1.98969449453327 0.00961358715947857 no 75 0.0233122997717708 64 4525169 SGTC_2935 9038016 29.96 µM 1.984170492074 0.00977963073541718 no 76 0.0236184184328606 50 6463195 SGTC_869 0564-0080 44.1 µM 1.98373151092283 0.00979293269151226 no 77 0.0236428893945767 36 6843321 SGTC_2800 7887935 81.82 µM 1.98076581000561 0.00988321375697613 no 78 0.0238087713369617 61 2961002 SGTC_861 0443-0273 110 µM 1.97095427132622 0.0101870935091264 no 79 0.0243645532936905 50 6149169 SGTC_1704 st028805 70.8 µM 1.93920326496709 0.0112270213100778 no 80 0.0262382961092303 63 2876101 SGTC_2262 9014885 67.46 µM 1.92681186867452 0.0116572389004462 no 81 0.0270015399111334 22 6457424 SGTC_2382 9035899 200 µM 1.92368328906348 0.011768097032873 no 82 0.0271971469675706 60 6462679 SGTC_2035 5154463 94.595 µM 1.9219592979439 0.0118295750570025 no 83 0.0273054397207665 79 2769623 SGTC_1307 1187-1599 12.2 µM 1.91987235584702 0.0119043686937178 no 84 0.0274370122575361 65 1538471 SGTC_2318 6029776 164 µM 1.91679608496071 0.012015366636782 no 85 0.027631921265568 54 818325 SGTC_2161 5662504 8.5105 µM 1.91648970581686 0.0120264703887957 no 86 0.0276513961342762 66 2859334 SGTC_1642 st009582 77.7 µM 1.91257222756135 0.012169233238147 no 87 0.0279014189517495 72 6739311 SGTC_2108 5365811 200 µM 1.89664701616728 0.0127648140859971 no 88 0.0289372704600054 57 780283 SGTC_481 bay k-8644 50 µM 1.88937785605569 0.0130449486546767 no 89 0.029420607951151 50 2303 A calcium channel antagonist. SGTC_46 0329-0187a 2.197 µM 1.8869071018257 0.0131413676868765 no 90 0.0295864108701586 69 46494817 SGTC_2412 st077135 33.4 µM 1.88337563904258 0.0132802488596207 no 91 0.0298247396744327 59 13258915 SGTC_439 amiodarone 34.4 µM 1.87512504739266 0.0136096683977551 no 92 0.0303877612291374 53 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1260 0700-1617 7.75 µM 1.87420232562852 0.0136469444706101 no 93 0.0304512718613941 60 2853078 SGTC_1605 st000082 49.1 µM 1.87383049085195 0.0136619907205309 no 94 0.0304768961926222 54 1114022 SGTC_2413 inermin 26.06 µM 1.87220803885003 0.0137278106522263 no 95 0.03058891368309 97 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2077 5212015 200 µM 1.87081213177926 0.0137846588188484 no 96 0.0306855627337493 53 780900 SGTC_2096 5468907 200 µM 1.85785171267835 0.0143222355771769 no 97 0.0315950375820492 54 759785 SGTC_899 1083-0020 478 µM 1.84943777388483 0.0146808159358461 no 98 0.0321973126262325 62 767123 SGTC_249 wiskostatin 11.211 µM 1.84360086583886 0.0149340838649555 no 99 0.0326206648782252 44 2775510 A n-wasp and actin depolymerizer. SGTC_3282 9108498 15.4605 µM 1.84287580003405 0.014965805797687 no 100 0.0326735731746772 68 16459645 SGTC_109 0132-0036 33.701 µM 1.83606422879457 0.0152666535165279 no 101 0.0331740789840432 58 67274 A color developer. SGTC_623 k072-0108 16.9 µM 1.82997853290498 0.0155398205063384 no 102 0.0336265744656143 73 5382803 SGTC_196 k015-0023 18.111 µM 1.82778409496183 0.0156393454963572 no 103 0.0337909805904171 36 5211998 SGTC_2022 5136654 200 µM 1.82151312601647 0.0159267744280013 no 104 0.0342644466196372 78 1713771 SGTC_1460 k062-0059 9.15 µM 1.81916386494528 0.016035612589445 no 105 0.0344432169657802 54 1373085 SGTC_394 menadione 8.33 µM 1.81542063540909 0.0162103484465306 no 106 0.0347296461356338 70 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1027 k015-0025 8.67 µM 1.81040543806428 0.0164470152867997 no 107 0.0351164683040828 59 3598955 SGTC_355 1311-2252 105 µM 1.80649048006405 0.0166338120654991 no 108 0.0354208799204884 67 5338538 SGTC_1306 1185-0270 9.02 µM 1.80434466806551 0.0167369645870896 no 109 0.0355886457115218 61 1548076 SGTC_1232 0279-0259 161 µM 1.79787628710005 0.017051227009914 no 110 0.03609830733472 59 1560000 SGTC_474 dl-dihydrosphingosine 5 µM 1.78859694316742 0.0175108579709909 no 111 0.0368398752607065 67 3058739 A sphingolipid protein kinase C inhibitor. SGTC_20 0481-0013 4.944 µM 1.78231892648785 0.0178277891912768 no 112 0.0373486190024592 89 182045 SGTC_413 propylparaben 100 µM 1.77849035096529 0.0180234578301403 no 113 0.0376616776483311 65 7175 A pharmaceutical preservative. SGTC_1011 4112-3381 17.4 µM 1.77244129189695 0.0183363406402643 no 114 0.0381606662832186 66 2877139 SGTC_164 4100-3994 89.624 µM 1.76148654604664 0.018914749623263 no 115 0.0390780440849495 74 4615967 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.76030513311393 0.0189780453204921 no 116 0.0391780421575487 70 688669 SGTC_807 1315-0151 48 µM 1.75625445552187 0.0191964349629195 no 117 0.0395224850929205 90 4011080 SGTC_39 0986-0283 58.349 µM 1.73275053330358 0.0205062259116751 no 118 0.0415700092417698 63 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_608 k048-0125 159 µM 1.72289795688289 0.0210773847890179 no 119 0.0424534899461765 64 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1492 4158-0558 28.5 µM 1.71577014215251 0.0214989298188033 no 120 0.0431020605029303 52 3967268 SGTC_2555 cholic acid 100 µM 1.70648356604469 0.0220588168755073 no 121 0.0439590417585688 54 6708657 Influences liver metabolism. SGTC_875 0709-0210 25.7 µM 1.70506122939606 0.0221456469951305 no 122 0.0440915027525126 82 6251364 SGTC_3034 9090421 49.47 µM 1.70038724672631 0.0224330160249067 no 123 0.0445290545475582 42 17173761 SGTC_199 4063-0024 41.6 µM 1.69492499511159 0.0227728289281788 no 124 0.0450448251106482 32 306215 SGTC_546 peri-Naphthalide 147 µM 1.68850998293904 0.0231774426854378 no 125 0.0456566871324924 111 223824 A penicillin ester. SGTC_2933 9026794 32.47 µM 1.68354744405644 0.0234945815249907 no 126 0.0461345814937379 68 17586027 SGTC_1520 flindersine 88 µM 1.66989965763141 0.0243856433277493 no 127 0.0474696090507183 84 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_561 1550-0330 72.9 µM 1.6686677841167 0.024467450049344 no 128 0.0475916185593813 72 6812934 SGTC_84 0443-0269 128.823 µM 1.66769814149455 0.0245320043563195 no 129 0.0476878322739681 72 6150058 SGTC_1176 0848-0131 83.3 µM 1.66636705012196 0.0246208549938655 no 130 0.0478201647119345 73 6769040 SGTC_1091 telmisartan 47.6 µM 1.65585409278843 0.0253321289152763 no 131 0.04887568512861 87 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2520 obtusaquinone 4.71 µM 1.65442676220465 0.0254300120143669 no 132 0.049020416288418 87 5967872 SGTC_518 1021-0119 62.6 µM 1.64956004062369 0.0257661453203863 no 133 0.049516476779316 95 1097762 SGTC_1489 4065-0444 182 µM 1.64240261272592 0.0262672422913434 no 134 0.0502532969160968 66 2877968 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.64173647186469 0.0263142909370919 no 135 0.0503223148552698 78 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2026 5148700 152 µM 1.63831908028692 0.0265567657855676 no 136 0.0506775747354006 84 79838 SGTC_2874 9043904 71.43 µM 1.63761797845432 0.0266067412723846 no 137 0.0507507051386749 87 4463428 SGTC_368 fentichlor 4.58 µM 1.62606136197381 0.0274418967975116 no 138 0.0519683012253845 74 7329 A pesticide. SGTC_1679 SEC14.276 6.7 µM 1.62598047341271 0.0274478184854295 no 139 0.0519769046632346 111 1005053 YMR079W SEC14 SGTC_1785 bathophenanthroline 24 µM 1.61927513560438 0.0279424209030377 no 140 0.0526940390167527 111 72812 An iron chelator. SGTC_2288 7946289 167.31 µM 1.61845497059984 0.0280034247224399 no 141 0.0527822917817916 82 1246052 SGTC_816 0325-0417 81.3 µM 1.61723081074638 0.0280946839473569 no 142 0.0529142339638745 85 68101 SGTC_1450 4112-4260 37.6 µM 1.61581522076481 0.0282005225994296 no 143 0.0530671348552233 85 1633175 SGTC_1015 4130-4525 82 µM 1.59892763115635 0.0294889423147088 no 144 0.0549183418272839 85 1363237 SGTC_629 3448-6466 76.7 µM 1.59526131321225 0.0297750221318989 no 145 0.0553269064558329 85 573744 SGTC_1500 4488-1866 171 µM 1.59301853508506 0.0299511566545359 no 146 0.0555780165217613 84 2900003 SGTC_884 0851-0618 334 µM 1.59056296778085 0.0301449924637126 no 147 0.0558539820744017 89 9642473 SGTC_297 0986-0032 24 µM 1.58149876527954 0.0308695211874007 no 148 0.0568820205199682 96 2847425 SGTC_2335 9018011 154.17 µM 1.58100339016319 0.0309095298643768 no 149 0.0569386312918549 92 6458208 SGTC_135 0933-0004 26.348 µM 1.57766342914291 0.0311804013718776 no 150 0.0573214760467306 94 21230617 YGL099W LSG1 SGTC_2398 5228213 48.84 µM 1.57621592633837 0.0312984025161729 no 151 0.0574880246819064 115 80771 YMR134W ERG29 SGTC_1284 0929-0043 16 µM 1.57461331400658 0.0314294788065202 no 152 0.0576728638890983 82 1239883 SGTC_1076 itraconazole 331 nM 1.5732745812342 0.0315393202169324 no 153 0.0578276262144462 98 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3090 9117696 49.47 µM 1.56291808158958 0.0323998234167277 no 154 0.0590359320493414 74 7923821 SGTC_1509 1326-1131 80 µM 1.5589222555503 0.0327369672362735 no 155 0.0595073910490857 66 768313 SGTC_687 k029-0044 34.9 µM 1.55783229366802 0.032829432160162 no 156 0.0596365042668744 55 5829338 SGTC_2375 9072683 200 µM 1.55699839874721 0.0329003193870145 no 157 0.0597354327926953 89 16798029 SGTC_431 k089-0097 107 µM 1.55638009664821 0.0329529610436646 no 158 0.0598088675938827 103 5499420 SGTC_1562 morin hydrate 59.1 µM 1.55331991704139 0.0332145248015666 no 159 0.0601733621573481 85 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3307 9126885 69.2785 µM 1.55070972309489 0.0334389760254697 no 160 0.0604856316808928 83 24824909 SGTC_435 c-PAF 6.7 µM 1.53862091150901 0.0344948380920994 no 161 0.0619484351772436 98 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_665 3914-0008 307 µM 1.53664194794165 0.0346702664264087 no 162 0.062190507132661 80 1069549 SGTC_2027 5150920 200 µM 1.53351224264649 0.0349491992166353 no 163 0.0625748462574626 71 786715 SGTC_1994 st072947 40.9 µM 1.52892595596723 0.0353612737046898 no 164 0.0631414004021769 84 5286565 YDL195W SEC31 SGTC_2309 7664088 163.95 µM 1.52519644811508 0.0356992974283248 no 165 0.0636050531307097 97 704922 SGTC_2324 6149169 200 µM 1.51924351194427 0.0362443248364445 no 166 0.0643506062826901 89 2888231 SGTC_2115 tiliquinol 12.7705 µM 1.51907076200251 0.0362602422905413 no 167 0.064372342663474 97 71208 A bioactive hydroxyquinoline. SGTC_592 k241-0073 46.5 µM 1.51328900703399 0.0367962919395504 no 168 0.0651031319014864 98 4230158 SGTC_1314 1222-0010 41.1 µM 1.51010238591853 0.0370944956530897 no 169 0.0655086504010684 85 3526027 SGTC_3069 9117009 49.47 µM 1.50700242160328 0.0373864824389265 no 170 0.0659050182451772 70 41904981 SGTC_2740 felodipine 17.08 µM 1.50589127994917 0.0374915972425816 no 171 0.0660475427228283 53 3333 L-type calcium channel blocker SGTC_1404 3909-7820 48.3 µM 1.50396937734301 0.0376739802923812 no 172 0.0662946258752583 95 23741373 SGTC_3004 9076122 71.4286 µM 1.49710772189676 0.0383310491714824 no 173 0.0671826154147001 91 44782551 SGTC_2646 retinol 96.75 µM 1.49136051715758 0.0388885621186787 no 174 0.0679334341398439 106 445354 A vitamin A analog and teratogen. SGTC_2311 7694451 200 µM 1.48655629169148 0.0393596520639725 no 175 0.068566019511983 133 2163142 SGTC_3271 9137798 49.47 µM 1.47767411862234 0.0402428382865996 no 176 0.0697475125224792 75 6498326 SGTC_2140 5586273 200 µM 1.46778127473371 0.0412453969483726 no 177 0.0710818227241104 96 854421 SGTC_2563 tomatine 8.54 µM 1.46453334534787 0.0415789292261283 no 178 0.0715241394958102 104 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1513 0337-0559 19 µM 1.46184541005936 0.0418566047952255 no 179 0.0718917885624379 92 775073 SGTC_1759 st043059 70 µM 1.45179511917317 0.0429081740113567 no 180 0.0732792907268202 116 669426 SGTC_1163 k060-0048 49.9 µM 1.44734569319963 0.0433804892348281 no 181 0.0739000637829622 103 6809982 SGTC_280 3448-3607 3.04 µM 1.43528415928097 0.0446819818324278 no 182 0.0756030699330961 74 626179 SGTC_1164 k060-0068 93.7 µM 1.4330068055179 0.0449312125474974 no 183 0.0759279462285433 105 5963676 SGTC_1469 k284-2957 126 µM 1.42740625075086 0.0455488918401095 no 184 0.0767314150764835 110 23884841 SGTC_3294 9122953 26.2835 µM 1.42636816659476 0.0456641276306161 no 185 0.076881048744807 103 16459826 SGTC_2032 5185112 25.99 µM 1.42582974898711 0.045723988603533 no 186 0.0769587457599915 88 5718189 SGTC_1660 st012960 28.1 µM 1.41609034657785 0.0468177393879121 no 187 0.0783745270504956 97 24207266 SGTC_1293 1000-1278 195 µM 1.41597223551926 0.0468311311309109 no 188 0.0783918168121606 117 678847 SGTC_2341 7987486 176.74 µM 1.41400419472511 0.0470547252469323 no 189 0.0786803354280071 102 1258686 SGTC_1158 4092-0494 91.8 µM 1.41206247734211 0.0472761667429743 no 190 0.0789657829291914 86 1148199 SGTC_2011 4012611 177 µM 1.4091058455376 0.047614956599877 no 191 0.0794019363153411 101 2049887 SGTC_2434 5670830 169.91 µM 1.40050291221101 0.0486118068101484 no 192 0.0806813859683534 113 1549830 SGTC_475 α-linolenic acid 10 µM 1.39847760287282 0.0488488957967935 no 193 0.0809848468974061 124 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3208 9114115 49.47 µM 1.38956163154808 0.0499036349617032 no 194 0.0823310167905082 143 650895 SGTC_1397 3532-0190 20.1 µM 1.384473444478 0.0505136487032182 no 195 0.0831067669502382 79 5322280 SGTC_3017 9080681 49.47 µM 1.38393972804062 0.0505779777886106 no 196 0.0831884553677035 103 16451914 SGTC_1479 0549-0158 134 µM 1.38254073247315 0.0507469091048783 no 197 0.0834028663347775 110 5440202 SGTC_956 1185-0240 191 µM 1.38253792045314 0.0507472491134403 no 198 0.0834032977246856 104 1416193 SGTC_3244 9134489 49.47 µM 1.37825089004244 0.0512677181151865 no 199 0.0840629200015771 115 16584271 SGTC_1810 st050138 53 µM 1.37744748355798 0.0513657269324009 no 200 0.0841869704212642 136 3444541 SGTC_371 0195-0006 7.36 µM 1.37445487223924 0.0517321123800106 no 201 0.0846502555132954 114 3928593 SGTC_911 3456-4043 236 µM 1.3738389729605 0.0518077740826349 no 202 0.0847458394748686 112 914281 SGTC_563 tetrahydrosecaminediol 614 µM 1.37214812272457 0.0520159430681132 no 203 0.0850086656047967 97 334274 A psychoactive constituent of the cannabis plant. SGTC_1657 st012939 43.4 µM 1.37017044031938 0.0522602679809861 no 204 0.0853168516545521 86 24207257 SGTC_1115 galangin 695.678 nM 1.36597828297191 0.0527811844676065 no 205 0.085972889931357 121 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2566 crystal violet carbinol 226 nM 1.36014874819487 0.0535123984823908 no 206 0.0868914286756619 150 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_881 0833-0569 170 µM 1.35939704354294 0.0536072681873921 no 207 0.087010403727098 107 5418700 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.35306179947869 0.0544121171295419 no 208 0.0880179441015368 105 4213774 SGTC_2552 juarezic acid 87.02 µM 1.35297646190232 0.0544230235661452 no 209 0.0880315750926772 102 1549512 SGTC_258 haloperidol 50.781 µM 1.35125794153604 0.0546430246478993 no 210 0.0883064098549294 144 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_550 4123-0385 25.7 µM 1.35097757974128 0.0546789825540732 no 211 0.0883513073839898 118 5731123 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.34819342785343 0.0550370811611207 no 212 0.0887980889432548 125 688662 SGTC_3160 9100216 49.47 µM 1.34801835265869 0.0550596611745938 no 213 0.0888262399266487 99 17191039 SGTC_2764 methyldopa 94.69 µM 1.34581891466223 0.0553439537769451 no 214 0.0891804619420192 109 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_185 k048-0037 25.491 µM 1.34275991583527 0.0557412763336873 no 215 0.0896748633362522 96 6827589 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.34202181933131 0.0558374813637725 no 216 0.0897944605380064 129 390807 SGTC_893 0958-0369 48.9 µM 1.33915634507221 0.0562122152878389 no 217 0.0902598903692006 129 6819948 SGTC_286 k060-0067 22.9 µM 1.33913277037757 0.0562153064845932 no 218 0.0902637269489104 130 5985051 SGTC_2625 euphol 100 µM 1.33860493878953 0.0562845527167109 no 219 0.0903496587388996 140 6708538 A triterpene alcohol. SGTC_598 3937-0236 20.2 µM 1.33710971123708 0.0564810767191852 no 220 0.0905934138583597 121 1379313 SGTC_2248 tofa 1.1 µM 1.33578330134027 0.0566558645748065 no 221 0.090810056273555 141 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1258 0671-0043 57.1 µM 1.33191108313041 0.0571685652265703 no 222 0.0914447043215521 132 4298767 SGTC_402 epigallocatechin gallate 10 µM 1.32975032820222 0.0574562431524926 no 223 0.0918002733405413 134 65064 An antioxidant. SGTC_896 0964-0007 44.5 µM 1.32686573636035 0.0578420645890181 no 224 0.0922765501941981 125 6756758 SGTC_7 0192-1582 4.227 µM 1.32464003339036 0.0581411476840305 no 225 0.0926452856089165 160 252616 SGTC_3106 9121286 49.47 µM 1.32342928393026 0.0583043539864787 no 226 0.0928463293415094 103 15943471 SGTC_2215 7188065 200 µM 1.31831463236343 0.0589977716503093 no 227 0.0936991723376802 115 940217 SGTC_2772 vinpocetine 57.06 µM 1.31811780126342 0.0590245857050033 no 228 0.093732108146224 120 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3086 9117350 49.47 µM 1.31514370257869 0.0594309080615807 no 229 0.0942308056851911 79 2679265 SGTC_606 k015-0008 38.6 µM 1.31424874537299 0.0595536056409964 no 230 0.094381254708719 123 1970475 SGTC_1208 2323-2347 50.3 µM 1.31361886116095 0.0596400809970602 no 231 0.0944872491308363 102 5412760 SGTC_1405 3909-7894 12 µM 1.31293236524229 0.0597344404702156 no 232 0.0946028698698015 116 7104060 SGTC_346 4513-0042 7.16 µM 1.31244689031316 0.0598012400064263 no 233 0.0946846972649526 135 2827372 SGTC_1967 st070177 51.4 µM 1.30996582603002 0.0601435393448678 no 234 0.0951036983409572 122 5729214 SGTC_3269 9137823 49.47 µM 1.30592316039153 0.0607045683292354 no 235 0.0957893447917303 90 17682936 SGTC_1106 tegaserod maleate 11.7 µM 1.3001329543437 0.0615152352450745 no 236 0.0967777023558962 138 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_507 nimesulide 162 µM 1.29863780160438 0.0617259339419725 no 237 0.097034129349313 123 4495 A COX2 inhibitor. SGTC_314 1671-0008 2.74 µM 1.29806852092547 0.0618063055920676 no 238 0.0971318951282737 144 3913060 SGTC_793 0488-0545 106 µM 1.29728716067182 0.0619167518395726 no 239 0.0972662002058735 125 292548 SGTC_635 k038-0028 24.7 µM 1.296178912114 0.0620736682548574 no 240 0.0974569265009328 152 4035102 SGTC_2463 5473429 200 µM 1.29433421752091 0.0623355455795222 no 241 0.0977750010508806 117 5399405 SGTC_1403 3909-7815 62.9 µM 1.29428989858471 0.0623418477856818 no 242 0.0977826521679146 121 6615483 SGTC_1503 4585-0012 61.3 µM 1.29399601050379 0.0623836515982934 no 243 0.0978333994211761 111 2922052 SGTC_190 3970-0790 3.722 µM 1.29025456347151 0.0629177624568656 no 244 0.0984811435149348 113 2832352 SGTC_1895 st058434 18.3 µM 1.2884169298314 0.0631813954238206 no 245 0.098800434282264 140 5393175 SGTC_1192 1488-0095 21.4 µM 1.2816697272802 0.0641567540174889 no 246 0.0999792643825929 117 915875 SGTC_2078 5212016 200 µM 1.27887310273307 0.064564441891577 no 247 0.100470872887046 121 1899708 SGTC_798 1287-0182 476 µM 1.27837191083407 0.0646377170997307 no 248 0.100559161644353 126 1649755 SGTC_833 3852-0053 558 µM 1.27372735730716 0.0653198358003094 no 249 0.101380028747795 138 3123681 SGTC_2612 dictamnine 15.46 µM 1.26982749406381 0.0658968878513896 no 250 0.102073042409953 158 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2327 6189656 200 µM 1.26670531750943 0.0663617088448865 no 251 0.102630338972826 118 5349088 SGTC_619 1652-1634 108 µM 1.26464635190798 0.0666696284479132 no 252 0.102999064638575 128 5400454 SGTC_3127 9126946 49.47 µM 1.26106061961626 0.0672085151053577 no 253 0.103643503734568 128 27243249 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.25895826759984 0.067526032477376 no 254 0.104022702942204 136 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2947 9072639 7.68 µM 1.25104291537192 0.0687318908501899 no 255 0.105459410272584 139 16488146 SGTC_1942 st076330 65.2 µM 1.25014481437571 0.0688697537202819 no 256 0.105623325847511 133 24208414 SGTC_302 1094-0063 18.9 µM 1.24691703942305 0.0693669932399601 no 257 0.106213959106347 162 5440289 SGTC_2753 fluvastatin 17.09 µM 1.24337181622033 0.0699163173498503 no 258 0.106865425512658 145 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_22 0964-0034 14.468 µM 1.24281799254518 0.0700024325269272 no 259 0.106967455357125 164 138402 SGTC_865 0488-0499 301 µM 1.24255387139902 0.0700435299937502 no 260 0.107016138615013 121 9634651 SGTC_105 0111-0055 734.78 µM 1.24252592431392 0.0700478796688459 no 261 0.107021290804011 115 5179370 SGTC_1636 st007707 68.9 µM 1.2410034681498 0.0702851483954209 no 262 0.10730223384449 142 403051 SGTC_672 1441-0018 53.7 µM 1.23856661386798 0.0706662081009163 no 263 0.107753019239398 110 251141 SGTC_2953 9074162 66.49 µM 1.23566278436929 0.0711223613245246 no 264 0.108291968227897 124 16451992 SGTC_1128 3448-9350 235 µM 1.2355371162315 0.0711421530505745 no 265 0.108315335874779 106 619386 SGTC_2504 purpurogallin 52.29 µM 1.22980746579861 0.0720490264963547 no 266 0.109384605916051 124 5281571 An antioxidant. SGTC_3180 9109287 49.47 µM 1.22884683150763 0.0722019367796401 no 267 0.109564619561001 144 18891271 SGTC_945 3381-0768 11.3 µM 1.22569252071388 0.0727057780353351 no 268 0.110157202917932 135 1126236 YIL048W NEO1 SGTC_158 k038-0087 26.446 µM 1.22400640994653 0.0729762041740559 no 269 0.110474904733 148 X158 SGTC_3100 9120536 49.47 µM 1.22273207242735 0.0731810985410268 no 270 0.11071545451936 130 16421196 SGTC_923 1900-2434 73.3 µM 1.2196386091612 0.0736803119699136 no 271 0.111300951709986 159 5910570 SGTC_2208 7283366 200 µM 1.21868991997072 0.0738339289117406 no 272 0.111480952630588 147 898663 SGTC_2752 diclazuril 33.15 µM 1.21781763779966 0.0739753894974862 no 273 0.111646640101665 136 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1815 st051655 58.2 µM 1.21777035803631 0.0739830629092076 no 274 0.111655625786383 152 5984156 SGTC_1048 3161-0300 24.5 µM 1.21732470984572 0.0740554206105659 no 275 0.111740348209511 120 2165101 SGTC_2247 cerulenin 830 nM 1.2120986468371 0.0749079898342461 no 276 0.112737310832672 145 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.20970936624805 0.0753002574168662 no 277 0.11319521728561 153 688788 SGTC_1214 0358-0031 63.7 µM 1.20647931667541 0.0758330477712432 no 278 0.113816364715678 148 4301366 SGTC_2469 5655019 90.81 µM 1.20456546577565 0.0761500854922 no 279 0.114185547579524 134 2788239 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.20235296575875 0.0765178519282067 no 280 0.114613401958114 104 6708630 An antioxidant. SGTC_66 0109-0187 42.4 µM 1.20100479969758 0.0767426084784357 no 281 0.114874669750683 117 759417 SGTC_41 0478-0632 82.643 µM 1.2006386992205 0.0768037287007833 no 282 0.114945691265416 155 3750424 SGTC_762 1165-0429 115 µM 1.19926638887245 0.0770331643786604 no 283 0.115212189982924 149 5967793 SGTC_2361 9034121 116 µM 1.19796622321052 0.0772510184254293 no 284 0.115465083353719 167 6496917 SGTC_1251 0490-5699 265 µM 1.19747830083803 0.0773328947331216 no 285 0.115560090155152 142 3883818 SGTC_728 3030-5151 22.5 µM 1.19586506157699 0.0776040752857381 no 286 0.115874610686782 128 3125388 SGTC_55 0767-0285 6.563 µM 1.18986712890243 0.0786186439756235 no 287 0.117049309981881 144 3116166 SGTC_2452 5863136 48.41 µM 1.18973090226189 0.0786418033316643 no 288 0.11707608771241 130 2184096 SGTC_1913 st060213 96.1 µM 1.18841149033308 0.0788663789907332 no 289 0.117335665845896 154 688959 SGTC_85 0868-0259 160.055 µM 1.18722789778509 0.0790682500869512 no 290 0.117568869774872 139 83173 SGTC_3105 9121040 49.47 µM 1.18691504854508 0.0791216743378211 no 291 0.117630565431935 113 41448907 SGTC_3168 9103419 49.47 µM 1.18678846106125 0.0791432990383915 no 292 0.117655535718086 132 16649256 SGTC_691 1548-0686 185 µM 1.18270542463349 0.0798431990183875 no 293 0.118462956785484 172 46495133 SGTC_1570 verbenone 133 µM 1.18179501482453 0.0799998946583627 no 294 0.118643523176455 149 29025 A natural terpanoid with antifungal properties. SGTC_556 4058-0063 51.5 µM 1.17699916463601 0.0808291754955904 no 295 0.119597919837943 147 6615692 SGTC_2278 7948257 134.34 µM 1.17124787206533 0.0818322070286468 no 296 0.120749578933884 134 1247028 SGTC_211 3455-0679 143.504 µM 1.17102767693142 0.0818707949175254 no 297 0.120793826207203 121 748649 SGTC_456 gingerol 170 µM 1.17048989810525 0.0819650951035893 no 298 0.120901938536625 152 442793 A herb. SGTC_2861 9024595 19.48 µM 1.16384489222952 0.0831370675961003 no 299 0.122243437805068 105 16482810 SGTC_372 0155-0182 15.9 µM 1.16378034809275 0.0831485126476825 no 300 0.122256519067273 142 771486 SGTC_1891 st059073 26.2 µM 1.16270963697468 0.0833385454433649 no 301 0.122473665152395 169 688754 SGTC_1057 3448-5381 134 µM 1.15893662324287 0.0840107930278837 no 302 0.123241009659765 153 5497911 SGTC_939 1165-0479 45.3 µM 1.15848667470674 0.0840912324754493 no 303 0.123332743224415 137 1377347 SGTC_2543 pimpinellin 60.67 µM 1.15745073689764 0.084276651816582 no 304 0.123544127589425 148 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1240 0356-0016 42.1 µM 1.15466762314474 0.0847763121572807 no 305 0.124113281446368 140 4305613 SGTC_370 0180-0345 38.7 µM 1.15356514436021 0.0849748564053827 no 306 0.124339247669756 131 3989527 SGTC_2395 5646831 180.19 µM 1.14813298238478 0.0859582208688 no 307 0.125456835110215 162 6808628 SGTC_217 ketoconazole 989 nM 1.14789344673829 0.0860017783478003 no 308 0.125506276926025 155 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_973 1325-0077 65.9 µM 1.14689326236511 0.0861838316595645 no 309 0.125712868828174 142 2835149 SGTC_575 k072-0246 11.9 µM 1.14319635441905 0.0868592441817652 no 310 0.126478537778316 152 6796779 SGTC_1344 1488-0097 29.1 µM 1.14208234968168 0.0870635424387314 no 311 0.126709895666531 161 747966 SGTC_1825 st052143 62.6 µM 1.13766209906264 0.0878777138055631 no 312 0.12763080265471 149 674173 SGTC_1041 0206-0046 107 µM 1.13668327810733 0.0880587695272441 no 313 0.127835356114255 153 50494 SGTC_2919 7978188 46.38 µM 1.1346656500273 0.0884328540774502 no 314 0.128257717433496 140 2980291 SGTC_2369 9071472 200 µM 1.13397492267953 0.0885611922003662 no 315 0.128402533638408 131 17296037 SGTC_1824 st053723 68.6 µM 1.13347138415405 0.0886548377768332 no 316 0.128508175805389 137 675225 SGTC_2346 9031566 143.75 µM 1.13228280614503 0.0888761760476692 no 317 0.128757778179547 140 4771086 SGTC_3177 9107506 49.47 µM 1.13013603204643 0.0892769928255414 no 318 0.129209454455989 136 8897194 SGTC_2348 9022543 33.42 µM 1.13004897972283 0.0892932743912918 no 319 0.12922779320566 182 3162678 YDL140C RPO21 SGTC_2848 9016370 25.97 µM 1.12807408050413 0.0896632374134768 no 320 0.129644317250058 140 7894410 SGTC_1461 k072-0203 53.8 µM 1.12711638279173 0.089843055232577 no 321 0.129846638779497 140 5418714 SGTC_1738 st035555 74 µM 1.12431095164646 0.0903713469325149 no 322 0.130440566979281 166 5331140 SGTC_3345 9148410 3.559 µM 1.12271709229836 0.0906725128800881 no 323 0.130778833204117 159 4903596 SGTC_1129 3453-1384 223 µM 1.11582004354263 0.0919843261191495 no 324 0.13224958619415 165 1084452 SGTC_1457 k015-0032 57.3 µM 1.11526849900565 0.092089833210758 no 325 0.132367690071155 155 4302660 SGTC_491 tetrandrine 80.3 µM 1.11496967908272 0.0921470330403417 no 326 0.132431707623671 143 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2746 daunorubicin 9.88 µM 1.11428253656671 0.0922786649897046 no 327 0.132578998224106 116 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_745 0469-0705 296 µM 1.11274085797927 0.0925745018228833 no 328 0.132909871163973 197 3486736 SGTC_1828 st055811 49 µM 1.11242583963959 0.092635037768012 no 329 0.132977549861605 142 5877589 SGTC_11 0438-0307 1.3 µM 1.10583412317512 0.0939084689290745 no 330 0.134399161245017 170 4011476 SGTC_2340 7987427 183.45 µM 1.10414732211095 0.0942364027121219 no 331 0.134764618161685 153 2239331 SGTC_2362 9071156 126 µM 1.10301895656825 0.0944562411480234 no 332 0.135009466513783 154 653133 SGTC_340 k038-0059 454 µM 1.10253596086603 0.0945504582499604 no 333 0.135114366791482 167 23733424 SGTC_2667 digitoxin 100 µM 1.10231350225643 0.0945938761465812 no 334 0.135162700653061 121 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_504 lovastatin 124 µM 1.10196689219179 0.094661554332014 no 335 0.135238032680516 170 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2088 5278280 127.392 µM 1.09816928329713 0.0954054045744868 no 336 0.136065288187413 153 791502 SGTC_2268 7933382 153.85 µM 1.09452682571171 0.0961228989573375 no 337 0.136861994359791 160 935025 YOR257W CDC31 SGTC_198 3454-2873 16.191 µM 1.09406413299118 0.0962143237789379 no 338 0.136963425823262 183 710957 SGTC_2860 9025725 38.96 µM 1.09160774403189 0.0967007595435675 no 339 0.137502775423252 160 40546248 SGTC_2829 7992743 58.44 µM 1.09083853669647 0.0968534554941503 no 340 0.137671968080704 156 16462845 SGTC_2840 9008771 71.43 µM 1.08814084145102 0.0973903762951498 no 341 0.138266468075191 109 2992978 SGTC_1263 0774-1208 64.8 µM 1.08369556470143 0.0982798752645531 no 342 0.139249901407485 187 906585 SGTC_73 0327-0325 16.231 µM 1.0818104377134 0.0986588802486592 no 343 0.139668383846272 124 53298 SGTC_1337 1486-1011 40.3 µM 1.08076136547369 0.098870259110088 no 344 0.139901639095779 152 X1337 SGTC_564 3555-0129 330 µM 1.08036707529525 0.0989497907406786 no 345 0.139989375690364 161 563260 SGTC_1969 st069479 40.1 µM 1.07749745821812 0.0995300267707649 no 346 0.140629042852698 164 3895485 SGTC_2999 9069765 71.4286 µM 1.07567879603115 0.099899044996001 no 347 0.141035466848233 153 2097066 SGTC_2581 avocatin a 64 µM 1.07341588075339 0.100359598973112 no 348 0.141542281174171 159 6710728 A skin care supplement. SGTC_2671 danthron 100 µM 1.06798372943502 0.101471483709283 no 349 0.142763925619556 178 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1691 st019933 84.6 µM 1.06745441149919 0.101580305478899 no 350 0.142883344668358 182 6176082 SGTC_1829 berberine 14.4 µM 1.06722192213054 0.101628129511082 no 351 0.142935817764494 187 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3304 9125678 46.087 µM 1.06230415583341 0.102643578630935 no 352 0.144048814188902 171 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2639 lactacystin 53 µM 1.06207530031816 0.102691012998331 no 353 0.144100751052769 161 3870 A proteasome inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.06027499277923 0.10306471440479 no 354 0.14450975627418 151 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1429 4049-0205 9.46 µM 1.05959460202895 0.103206204369951 no 355 0.144664535205252 159 22774478 SGTC_1752 st044819 83.042 µM 1.05737754804268 0.103668228090522 no 356 0.145169657044643 164 441209 YML126C ERG13 SGTC_1762 st045503 25.4615 µM 1.05550407555997 0.104059819394339 no 357 0.145597423259697 161 4645554 SGTC_1169 aniline yellow 25.8 µM 1.05436066114165 0.104299341118994 no 358 0.145858912854122 182 6051 A DNA damaging agent. SGTC_212 3807-4682 38.772 µM 1.05351598865158 0.104476539015157 no 359 0.146052285172293 177 3125501 YBL034C STU1 SGTC_2650 prasterone 100 µM 1.05099014183476 0.105007719754419 no 360 0.146631558767837 137 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2899 9053889 58.44 µM 1.05036219373521 0.105140078918865 no 361 0.146775810336903 168 6470052 SGTC_3157 9099274 49.47 µM 1.04741666111121 0.105762551058994 no 362 0.147453725345686 167 17217662 SGTC_859 0439-0102 54.6 µM 1.04402268293284 0.10648309028228 no 363 0.148237447616957 195 610143 SGTC_1612 st002233 45.4 µM 1.04307376973075 0.106685176402567 no 364 0.14845706400897 161 1035021 SGTC_2908 7930301 100 µM 1.0411071506505 0.107104880109003 no 365 0.148912910614475 189 2223178 SGTC_2015 5119600 184 µM 1.0406742939843 0.107197417380412 no 366 0.149013368779035 192 2828786 SGTC_826 1683-5028 118 µM 1.03886030812075 0.107585843223061 no 367 0.149434854245114 152 722377 SGTC_387 norethindrone acetate 66.7 µM 1.03440665453057 0.108543796014015 no 368 0.150473047380101 168 541197 SGTC_1821 st053465 65.6 µM 1.03342711981767 0.1087553084091 no 369 0.150702030223462 158 675086 SGTC_1499 4480-0877 67.3 µM 1.03244839699729 0.108966941342601 no 370 0.150931054896505 163 2861909 SGTC_1557 sumaresinolic acid 42.3 µM 1.03158073353534 0.109154806901804 no 371 0.151134284900081 152 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1912 st060209 90.8 µM 1.02985034890475 0.109530162601161 no 372 0.151540130667297 182 688787 SGTC_1271 0832-2808 169 µM 1.02967915808309 0.109567347704976 no 373 0.151580321245438 206 3663794 SGTC_1983 st071813 46.9 µM 1.02586119498393 0.110399020767922 no 374 0.152478508052532 176 11838595 SGTC_1354 1498-1681 81 µM 1.02406593326436 0.110791646246718 no 375 0.15290206688105 169 5754243 SGTC_1716 st033144 30.6155 µM 1.02250177068961 0.111134544863808 no 376 0.153271737509017 185 674617 SGTC_245 methotrexate 289.6 µM 1.02245453707645 0.111144911311514 no 377 0.153282909797409 164 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1764 st044502 93.5 µM 1.01962088174556 0.111768086139306 no 378 0.153954148806938 167 8407 SGTC_773 4358-1457 44.6 µM 1.01866965073965 0.111977839212585 no 379 0.154179912731757 191 1186886 SGTC_56 0957-0365 83.25 µM 1.01418032097364 0.112971566419822 no 380 0.155248358497038 176 6752360 SGTC_132 0417-1715 25.805 µM 1.01392203699679 0.11302892926355 no 381 0.155309977556847 176 6769098 SGTC_2030 5175110 200 µM 1.01309033118056 0.113213785828431 no 382 0.155508508081921 173 2831986 SGTC_1045 1348-1485 165 µM 1.01299788127005 0.113234347239524 no 383 0.155530586471347 182 6810614 SGTC_471 1-acyl-paf 4 µM 1.01088974979159 0.113703931424898 no 384 0.156034600250482 165 16759367 SGTC_727 3032-0951 202 µM 1.00477257282182 0.115074379607993 no 385 0.15750318675569 172 3652836 SGTC_1720 st037298 9.481 µM 1.00451962848138 0.115131299224834 no 386 0.157564107517884 188 597396 SGTC_1346 1488-2224 62.4 µM 1.0033608366778 0.115392316005688 no 387 0.157843396399635 183 3722427 SGTC_2648 atorvastatin 78.68 µM 1.00187490716597 0.115727635274186 no 388 0.158202006582899 172 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2910 7948405 25.97 µM 1.00158865036065 0.115792312260134 no 389 0.158271152396619 162 2971328 SGTC_3114 9122766 49.47 µM 0.99712119828429 0.116805018121962 no 390 0.159352842333076 150 17176985 SGTC_1889 st059080 5.18 µM 0.996890859569321 0.116857402208007 no 391 0.159408744427976 154 176925 Isolated from Daphnopsis sellowiana. SGTC_1615 st002656 86.5 µM 0.996673950083664 0.116906747414549 no 392 0.159461399050672 166 1584458 SGTC_994 3910-0338 138 µM 0.996553655184156 0.116934119926044 no 393 0.15949060545919 203 3479481 SGTC_3327 9140648 26.9345 µM 0.994548510046484 0.117391049811594 no 394 0.159977950420243 220 8029710 SGTC_2518 prenyletin 46.28 µM 0.994279909805639 0.11745235398682 no 395 0.160043306850803 148 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3248 9135562 49.47 µM 0.991013827451246 0.118199604831055 no 396 0.160839414206941 181 17650701 SGTC_1315 1237-0019 3.69 µM 0.986675609468657 0.119197340142581 no 397 0.16190084539141 179 825140 SGTC_658 3253-0951 102 µM 0.986018837299873 0.119348906039433 no 398 0.162061934587902 192 1184878 SGTC_1298 1079-1278 263 µM 0.985023697529074 0.119578817423179 no 399 0.162306215436397 188 2840950 SGTC_735 3076-0345 636 µM 0.982961215351497 0.120056315767828 no 400 0.162813263784907 192 2888990 SGTC_1430 4049-0248 69.1 µM 0.980610020086735 0.120602293199966 no 401 0.163392545584708 203 22774488 SGTC_744 1594-0068 283 µM 0.978634968438589 0.121062274481056 no 402 0.163880187410368 204 668392 SGTC_110 0850-0284 111.64 µM 0.978440274856964 0.121107684542398 no 403 0.163928308497099 159 3906265 SGTC_74 000s-0487 160.283 µM 0.978279468006 0.121145199943791 no 404 0.163968060944501 188 677548 SGTC_3200 9114385 49.47 µM 0.973116373746793 0.122354069792443 no 405 0.165247733538748 174 17018030 YLR208W SEC13 SGTC_756 0508-1999 28.3 µM 0.972474675256287 0.122504904425567 no 406 0.165407228838324 188 6753853 SGTC_1645 Cervolide 78 µM 0.972381699989551 0.122526769572032 no 407 0.165430346263862 194 23173 A fragrance. SGTC_1273 0849-0096 14.1 µM 0.972006267851355 0.122615088417646 no 408 0.165523715193084 206 5286025 SGTC_345 1362-0200 395 µM 0.971901487872376 0.122639745440622 no 409 0.165549779765401 182 1419823 SGTC_1878 temozolomide 1 mM 0.968697087857779 0.123395491196369 no 410 0.166348172988325 187 5394 DNA alkylating agent. SGTC_140 0062-0056 502.533 µM 0.967924836009628 0.12357811075513 no 411 0.166540954817505 160 3758964 SGTC_1436 4092-1007 8.32 µM 0.966477369887922 0.123920912422535 no 412 0.166902682720087 164 2881121 SGTC_522 1273-0010 11.6 µM 0.966030001793311 0.124026996581945 no 413 0.167014584341736 205 5705015 SGTC_2669 eugenol 100 µM 0.965325730635278 0.124194128764688 no 414 0.167190843965728 160 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2338 7999974 200 µM 0.963982372941963 0.124513360743635 no 415 0.167527381687057 200 315925 SGTC_2255 7941087 197.44 µM 0.963650175400678 0.124592391687333 no 416 0.167610671009344 183 935561 SGTC_1686 st019653 115.5 µM 0.9635986346063 0.124604656562101 no 417 0.167623595824097 199 97252 SGTC_589 1227-0070 34.1 µM 0.963480495229086 0.124632772713674 no 418 0.167653223896694 179 2841384 SGTC_2114 5491910 81.25 µM 0.960446562672443 0.125356342096718 no 419 0.168415256585248 192 2849228 SGTC_2843 9000894 45.46 µM 0.96020183906367 0.125414834325902 no 420 0.168476820729515 125 2242070 SGTC_2083 5306046 65.942 µM 0.958543420802879 0.125811720550722 no 421 0.168894403638216 193 539837 SGTC_149 3970-0822 46.1 µM 0.958108164502831 0.125916029374005 no 422 0.169004109451322 202 3114250 YBL034C STU1 SGTC_2717 st081029 62.2815 µM 0.957995462671841 0.125943048104312 no 423 0.169032523267031 198 5292846 SGTC_857 0438-0306 1.35 µM 0.9578371409742 0.125981010405216 no 424 0.169072443714884 175 4686136 SGTC_2148 5546263 113.568 µM 0.95365368430517 0.126987009489008 no 425 0.170129485899552 183 792097 SGTC_2619 obliquin 87.91 µM 0.953019892171422 0.127139904319195 no 426 0.170289996018228 193 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2473 5854593 8.94 µM 0.952213003758594 0.127334741851799 no 427 0.170494483712806 205 2872951 SGTC_2176 5809774 33.9695 µM 0.951170184384208 0.127586856619494 no 428 0.170758995622768 169 2870539 SGTC_3326 9140064 16.379 µM 0.945788642754288 0.128893428093633 no 429 0.172128199730976 189 1868434 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.944613035610312 0.129180081653388 no 430 0.172428234738281 206 689007 SGTC_732 3970-1727 52.7 µM 0.942872920458245 0.129605192432758 no 431 0.172872953736517 214 1275699 SGTC_534 k292-0788 63.4 µM 0.940915952403785 0.130084437044859 no 432 0.173373965974367 232 4146317 SGTC_1422 4031-0024 15.5 µM 0.94071271046561 0.130134279454618 no 433 0.173426051794562 215 782427 SGTC_749 1000-0129 128 µM 0.940686851315293 0.130140622018404 no 434 0.173432679561553 190 708470 SGTC_418 lividomycin a 100 µM 0.939287393348983 0.130484191036386 no 435 0.173791604698992 191 72394 An antibiotic. SGTC_1791 st048313 56.1 µM 0.939079268004693 0.130535339650202 no 436 0.173845023850132 179 1204976 SGTC_2644 guaiazulene 100 µM 0.938758732166019 0.130614141237752 no 437 0.173927315620995 185 3515 A coloring agent. SGTC_2791 5663188 71.43 µM 0.934894858777455 0.131566636907841 no 438 0.174921243448808 222 54690634 SGTC_1938 st074717 56.4 µM 0.933289762953939 0.131963720164301 no 439 0.175335189629651 196 17250979 SGTC_1172 0370-0043 85 µM 0.933242651531084 0.131975387491344 no 440 0.175347348804969 175 376585 SGTC_2780 5215298 71.43 µM 0.933066271349797 0.132019075046835 no 441 0.175392876217988 221 2834131 SGTC_1068 loratadine 26.9 µM 0.932993676402986 0.132037058964839 no 442 0.175411616668505 193 3957 A H1 histamine antagonist. SGTC_2914 7968218 45.32 µM 0.932474261537372 0.132165782695676 no 443 0.175545741112627 160 2977111 SGTC_1168 k815-0004 80.5 µM 0.931103065781498 0.132506014196421 no 444 0.175900126452652 218 642433 SGTC_729 4092-0585 94.1 µM 0.930405278558605 0.132679385955288 no 445 0.176080643283226 192 2169061 SGTC_3071 9117417 49.47 µM 0.928746518948521 0.133092147273603 no 446 0.176510233235622 194 45595590 YGL055W OLE1 SGTC_1908 st060353 56.5 µM 0.928119010689817 0.133248524927301 no 447 0.176672919664261 220 4227716 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.927138663472655 0.133493084467177 no 448 0.176927272048139 205 23847180 SGTC_1367 1812-0510 76.9 µM 0.924411270456622 0.134175089255797 no 449 0.177636114486132 197 1142582 YDR527W RBA50 SGTC_2551 apiole 73.87 µM 0.923008683614227 0.134526746776981 no 450 0.178001339978128 175 10659 A possible DNA adduct former. SGTC_2628 lathosterol 100 µM 0.921594061677189 0.134882062067234 no 451 0.178370178572758 200 6710616 SGTC_210 3551-0445 56.827 µM 0.920996427157712 0.135032365187847 no 452 0.178526146188846 191 2865180 YOR207C RET1 SGTC_2716 st080858 38.6235 µM 0.918792751529797 0.135587574809783 no 453 0.17910199226328 200 5296050 SGTC_440 fluspirilene 35.1 µM 0.918758625857324 0.135596184952725 no 454 0.179110918876312 205 3396 An atypical antipsychotic. SGTC_214 4373-3496 70 µM 0.917879392322937 0.135818150808965 no 455 0.179341005785783 222 3779166 SGTC_1629 st005085 44.9 µM 0.917112050736911 0.136012072356302 no 456 0.179541963461836 224 24207091 SGTC_3299 9121982 43.1275 µM 0.915785248603787 0.136347827069531 no 457 0.179889771010632 190 17594604 YPL160W CDC60 SGTC_2273 7815444 169.05 µM 0.915209872059049 0.1364936054522 no 458 0.180040731517693 217 2824616 SGTC_1861 st057647 17.4 µM 0.911859919276997 0.137344472064901 no 459 0.180921231507569 195 688668 SGTC_147 4466-0538 29.23 µM 0.911401072122284 0.137461297739511 no 460 0.181042044465007 218 6742687 YHR072W ERG7 SGTC_1644 st010134 20.9 µM 0.910095140399864 0.137794168288439 no 461 0.181386168592043 222 3818134 SGTC_2103 5378138 10 µM 0.910034621450577 0.137809607361122 no 462 0.181402125773091 209 244142 SGTC_3344 9148862 3.898 µM 0.909691519258313 0.137897158948237 no 463 0.181492608991537 209 4905352 SGTC_1118 chelidonine 707.474 nM 0.90778184933899 0.13838515494974 no 464 0.181996744928867 202 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2536 dehydroabietamide 32.04 µM 0.907437393929058 0.138473302042108 no 465 0.182087771231183 182 3983547 SGTC_1254 0550-0035 264 µM 0.906753886355339 0.138648326790078 no 466 0.182268480221676 205 15121435 SGTC_10 0279-0212 42.575 µM 0.906175624796512 0.138796518986226 no 467 0.182421451254879 200 39851 YBR002C RER2 SGTC_1392 3455-1037 33.9 µM 0.906096145698736 0.138816895675758 no 468 0.182442482609713 192 981132 SGTC_3302 9125395 16.351 µM 0.905091625666027 0.139074608072096 no 469 0.182708424131939 197 17599668 SGTC_552 k242-0005 476 µM 0.903944879561637 0.139369206830002 no 470 0.183012314972117 234 4088318 SGTC_1678 st019265 80.2 µM 0.902979723003283 0.139617484085726 no 471 0.183268328354888 195 5367020 SGTC_2004 4023728 41.89 µM 0.90002176365247 0.140380263216401 no 472 0.184054334416568 238 360084 YDR527W RBA50 SGTC_1954 st077032 68.9 µM 0.900015571830585 0.14038186288499 no 473 0.184055981941361 225 698907 SGTC_2748 diazoxide 86.69 µM 0.898779115699461 0.140701551650792 no 474 0.184385163112615 150 3019 A potassium channel activatior. SGTC_646 4092-0839 27.3 µM 0.89861300243421 0.140744538258869 no 475 0.184429415266239 227 877796 SGTC_1132 3456-3614 2.5 µM 0.898299952808541 0.140825573117099 no 476 0.184512828850035 183 3125502 SGTC_2944 9067346 25.62 µM 0.893770902771524 0.142001488113341 no 477 0.185722240216256 208 6473075 SGTC_1662 st014054 52 µM 0.890376741366314 0.142887087986099 no 478 0.186631813451701 215 2838777 SGTC_1971 st069429 63.5 µM 0.890276925975402 0.142913188056356 no 479 0.186658603833106 198 1246522 YGL099W LSG1 SGTC_3253 9135987 49.47 µM 0.889319173348903 0.143163788267888 no 480 0.186915784983049 205 4182430 SGTC_316 k060-0003 58.6 µM 0.888810070732004 0.143297117976539 no 481 0.187052581304465 220 6152314 SGTC_1088 bifonazole 369 nM 0.888560653605612 0.143362468826519 no 482 0.187119622502807 211 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_378 3970-0959 8.33 µM 0.884905148207049 0.14432257237713 no 483 0.188103895571707 221 6615653 SGTC_1379 2144-0755 36.5 µM 0.88482450281471 0.1443438023053 no 484 0.188125645930604 235 5392327 SGTC_1560 lithocholic acid 53.1 µM 0.884649488474032 0.144389882132749 no 485 0.188172853280948 203 9903 A bile acid which acts as a detergent. SGTC_380 3970-0968 6 µM 0.883866624652572 0.144596125044192 no 486 0.188384107886587 219 2891601 SGTC_247 mechlorethamine 29.705 µM 0.882922011537487 0.144845244356619 no 487 0.188639204956652 193 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1681 tripelennamine 100 µM 0.882546330142339 0.144944401695658 no 488 0.188740718587971 185 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2052 5265182 7.135 µM 0.879582807904833 0.145728195607753 no 489 0.189542677827086 211 1239884 SGTC_1071 trifluoperazine 6.31 µM 0.878975218784703 0.145889242394224 no 490 0.189707356236122 227 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2483 5729050 27.16 µM 0.8747180080929 0.147021007371909 no 491 0.190863679624827 212 2865180 SGTC_2201 6605497 169.863 µM 0.872553915208047 0.147598575323405 no 492 0.191453134450626 217 670741 SGTC_2380 9035439 200 µM 0.871920235493352 0.147767983397922 no 493 0.19162594680515 201 6462575 SGTC_525 k781-2675 26.7 µM 0.871141706408095 0.14797629371599 no 494 0.191838392137402 206 3651118 YDL195W SEC31 SGTC_532 1548-0774 215 µM 0.869065314541319 0.148532832817292 no 495 0.192405703532483 224 5932993 SGTC_2771 fluoxetine 41.05 µM 0.868036628246966 0.148809071268411 no 496 0.192687140606873 217 3386 A selective serotonin reuptake inhibitor. SGTC_1637 st007924 17.4 µM 0.867508718544401 0.148950966814969 no 497 0.19283166842598 195 683336 SGTC_3329 9141233 27.5565 µM 0.865626695065671 0.149457566660611 no 498 0.193347455704876 210 4909101 YNL103W MET4 SGTC_1996 st072960 66.8 µM 0.863744258258504 0.1499654269007 no 499 0.19386419750657 208 1719405 SGTC_579 4491-1009 110 µM 0.863308946480031 0.150083032745349 no 500 0.19398381329879 261 1271041 SGTC_2586 curcumin 80 µM 0.862652929510358 0.150260381445946 no 501 0.194164159811253 210 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3087 9117406 49.47 µM 0.861776817207134 0.150497448807357 no 502 0.19440517223848 207 42546093 SGTC_2886 9058944 51.95 µM 0.857144328287818 0.151755094532692 no 503 0.195682562683762 170 4949929 SGTC_2237 6667747 47.222 µM 0.856075934424956 0.152046134423343 no 504 0.195977889540687 217 729940 YDL015C TSC13 SGTC_2749 bexarotene 57.39 µM 0.85582203276073 0.152115353952651 no 505 0.19604811312252 233 82146 An retinoic acid receptor inhibitor. SGTC_3153 9100258 49.47 µM 0.855646163886824 0.15216331218485 no 506 0.196096763507685 214 25236848 SGTC_2825 7998094 58.44 µM 0.853890985578922 0.152642487286704 no 507 0.196582697358269 201 2987815 SGTC_1322 1348-1070 12 µM 0.853652032082605 0.152707800481143 no 508 0.196648909743162 222 6758089 SGTC_2150 5556613 200 µM 0.853254706007149 0.152816442707988 no 509 0.196759035992703 228 743190 SGTC_1141 3253-0389 52.6 µM 0.853221883567862 0.152825419751259 no 510 0.196768135006913 232 5402031 SGTC_1923 st058458 19.1 µM 0.853197067504189 0.152832207257069 no 511 0.196775014668305 253 3534982 SGTC_2493 resveratrol 26.09 µM 0.852033204821782 0.153150762901556 no 512 0.19709783141582 189 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_410 α-linolenic acid 100 µM 0.851039246926234 0.153423162801415 no 513 0.197373775797746 230 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1079 idarubicin 2.36 µM 0.850976192911546 0.153440453936816 no 514 0.197391288844503 243 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3007 9078383 71.4286 µM 0.849844649813038 0.153750973429021 no 515 0.197705730977916 217 6496995 SGTC_2082 5219693 150 µM 0.847814913037772 0.154309018015633 no 516 0.198270528227344 214 2834649 SGTC_2089 5281248 129.67 µM 0.847336370727977 0.154440780654339 no 517 0.198403829777802 206 2737878 SGTC_785 1270-0111 65.3 µM 0.846581960935881 0.154648652119367 no 518 0.198614086076599 228 6741994 SGTC_218 alverine citrate 93.75 µM 0.845115508986344 0.155053249761665 no 519 0.199023174989168 228 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3117 9124945 49.47 µM 0.844052856065754 0.155346874641255 no 520 0.199319935083241 194 17592065 SGTC_565 1418-0001 44.5 µM 0.843861647219826 0.155399747070666 no 521 0.19937336099194 226 2862145 SGTC_1997 st073024 93.8 µM 0.843666996000651 0.155453583569114 no 522 0.199427757593935 221 686268 SGTC_88 0180-0332 8.668 µM 0.843446828563423 0.155514492154892 no 523 0.199489295643109 237 3101745 SGTC_2310 7668677 200 µM 0.843308127834539 0.155552871330292 no 524 0.199528069152416 234 2197143 SGTC_2424 5537928 59.2 µM 0.841700689155358 0.15599811330076 no 525 0.199977756206322 240 5382802 SGTC_1693 xanthone 101.9 µM 0.840719497462594 0.156270304521072 no 526 0.200252547558535 260 7020 An insecticide. SGTC_2647 atorvastatin 60.16 µM 0.840268830716283 0.156395428233267 no 527 0.200378836742626 204 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2438 5259590 200 µM 0.838535694208898 0.156877233165299 no 528 0.200864954749406 223 1201127 SGTC_801 0866-0028 10.1 µM 0.83771996128668 0.157104341261516 no 529 0.201093999941829 233 6849771 SGTC_226 1,3-diallylurea 8.28947 mM 0.837378953960678 0.157199345124554 no 530 0.201189795936929 230 74537 YKL182W FAS1 SGTC_2968 9090663 33.37 µM 0.835113161872944 0.157831548828568 no 531 0.201826998341815 257 25236811 SGTC_1630 st005209 31.3 µM 0.83481445223312 0.157915019512943 no 532 0.201911093684187 235 3367314 SGTC_3318 9139014 38.6185 µM 0.834475138493252 0.158009871665011 no 533 0.202006645690105 252 16643984 SGTC_2236 dapsone 200 µM 0.832950409962047 0.158436557598961 no 534 0.202436348832251 215 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3283 9109332 35.8195 µM 0.832398149788426 0.158591290505115 no 535 0.202592123028539 199 17027281 SGTC_1191 1487-1166 10.6 µM 0.832208221725394 0.15864452766624 no 536 0.202645711960564 232 3955771 SGTC_1694 st024011 44.9 µM 0.83111873116632 0.15895014010977 no 537 0.202953279551646 244 2787533 SGTC_1734 st037168 69.4 µM 0.830036274525523 0.159254161286392 no 538 0.203259137374237 216 708907 SGTC_1218 1348-1416 30.7 µM 0.829637553696594 0.159366242814692 no 539 0.203371868809163 236 6787668 SGTC_3118 9124250 49.47 µM 0.824619082154867 0.160781364023089 no 540 0.204793942172582 217 1504786 SGTC_2506 ethyl hematommate 54.16 µM 0.823386041790504 0.161130311630025 no 541 0.205144249054127 218 3940691 An allergen. SGTC_2738 aclarubicin 5.55 µM 0.823219347842488 0.161177523525898 no 542 0.205191634128252 193 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2884 9058502 51.95 µM 0.82223205472197 0.161457334642221 no 543 0.205472419237363 221 6471554 SGTC_1398 3558-0053 112 µM 0.822079737196861 0.161500531504837 no 544 0.205515758484756 215 4532369 SGTC_2576 guaiol 23.12 µM 0.821284003017093 0.161726322192277 no 545 0.205742258745351 219 227829 SGTC_1194 1488-0194 225 µM 0.821191714542533 0.161752522483668 no 546 0.205768537608163 230 1391452 SGTC_1299 1079-1439 3.74 µM 0.820808652729915 0.161861301611605 no 547 0.205877634584827 239 323161 SGTC_3252 9135871 49.47 µM 0.82008189914755 0.162067810811431 no 548 0.206084710134909 236 17682838 SGTC_1835 st008666 49.2 µM 0.819611555557201 0.162201551769105 no 549 0.20621879200799 210 690455 SGTC_3215 9129942 49.47 µM 0.818757801192394 0.162444498116626 no 550 0.206462305709883 250 17682944 SGTC_2745 rifampicin 24.3 µM 0.818269517562522 0.162583551649538 no 551 0.206601653877452 182 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2662 daunorubicin 22.37 µM 0.817620242031422 0.16276857241315 no 552 0.206787032755739 227 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1495 4469-0029 237 µM 0.817294654153016 0.162861405076458 no 553 0.206880030527245 235 793680 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.815773593346392 0.163295550849856 no 554 0.207314819466645 232 2724278 An inhibitor of dopamine biosynthesis. SGTC_2347 9049783 174.81 µM 0.812363397214005 0.164271629315583 no 555 0.208291571319903 257 6467988 YPL169C MEX67 SGTC_2763 lisinopril 49.32 µM 0.811843995425726 0.164420625653341 no 556 0.208440576787175 243 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3164 9100705 49.47 µM 0.811401331267546 0.164547678049231 no 557 0.208567617443627 204 17174235 SGTC_1979 st071809 45.3 µM 0.811045665804485 0.16464980637555 no 558 0.20866972331823 245 4976333 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.810952971964818 0.16467642989345 no 559 0.208696339078585 225 88881 An O-methylated flavonoid and antioxidant. SGTC_496 calpeptin 138 µM 0.810397082433273 0.164836150960871 no 560 0.208855997082615 221 73364 A calpain inhibitor. SGTC_2815 7968870 71.43 µM 0.807451820680931 0.165684072372082 no 561 0.209703110787663 220 2977326 YHR190W ERG9 SGTC_1854 st056233 32.9 µM 0.80408714237528 0.166656186099577 no 562 0.210673324830694 247 5393174 SGTC_670 4204-0025 119 µM 0.803907638637493 0.166708151049601 no 563 0.210725159104937 216 719039 SGTC_179 1273-0063 6.77 µM 0.802932150477821 0.16699073013495 no 564 0.21100697604503 230 3108139 SGTC_2350 9023895 38.85 µM 0.802180717969351 0.167208615354534 no 565 0.211224214243307 226 2997209 SGTC_1474 0330-0125 5.35 µM 0.800428101341773 0.167717515556585 no 566 0.211731402479118 235 X1474 SGTC_1837 st055472 66.5 µM 0.798182402204727 0.168371046329396 no 567 0.212382324023546 228 676091 SGTC_2145 5634607 200 µM 0.796676185042054 0.168810293551994 no 568 0.212819559234077 229 308662 SGTC_2692 st077426 47.7 µM 0.796565604509595 0.168842570340179 no 569 0.212851680011666 239 25238571 SGTC_3012 9080433 71.4286 µM 0.795466261489601 0.169163667608402 no 570 0.213171164521896 261 17688859 SGTC_1885 st057546 99.9 µM 0.794035736236036 0.169582083589664 no 571 0.213587313712108 212 702008 SGTC_3210 9128157 49.47 µM 0.793050090535346 0.169870762237288 no 572 0.213874319744468 219 17590849 SGTC_3133 9127736 49.47 µM 0.7927543011261 0.169957455289614 no 573 0.213960493206502 223 27243420 SGTC_2175 5807670 165.306 µM 0.792696663597785 0.169974351600245 no 574 0.213977287321215 209 241186 SGTC_1946 st076057 65.1 µM 0.792666640029173 0.169983153367773 no 575 0.213986035732005 231 953009 SGTC_935 2996-0153 430 µM 0.791782520760053 0.170242474457662 no 576 0.214243747951778 246 23738523 SGTC_485 niflumic acid 177 µM 0.791011396016593 0.170468859945308 no 577 0.214468670708434 237 4488 A COX2 inhibitor. SGTC_1272 0839-0021 27 µM 0.790523107615886 0.170612310462614 no 578 0.214611166327543 246 5027250 SGTC_2177 5811945 192 µM 0.790385289951677 0.170652812841376 no 579 0.214651395164833 238 5343475 SGTC_2654 protoveratrine a 100 µM 0.789853539413718 0.170809143393553 no 580 0.214806653682482 258 5702278 A heart drug and vasodilator. SGTC_1795 st049545 62.3 µM 0.789729538749125 0.170845611804953 no 581 0.214842868307895 212 5291882 SGTC_1737 st035557 69.7 µM 0.789448410642417 0.170928309614837 no 582 0.214924985430471 255 5716916 SGTC_2053 5265679 138 µM 0.788839206675297 0.171107603446314 no 583 0.21510299558892 269 764595 SGTC_2606 farnesol 9.78 µM 0.787820992922841 0.171407540701328 no 584 0.215400709925697 255 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2366 9070441 60.58 µM 0.787727745424267 0.171435025589902 no 585 0.215427986396944 225 6837235 SGTC_412 gemfibrozil 100 µM 0.786146418531472 0.171901553750628 no 586 0.215890856296805 221 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1097 itavastatin 7.23 µM 0.785559824738941 0.172074818480278 no 587 0.21606270448689 241 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2629 bisabolol 100 µM 0.785381662855148 0.172127464983762 no 588 0.216114914375718 267 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_175 3793-3120 23.7 µM 0.785312545838593 0.172147891700266 no 589 0.216135170909347 263 5322297 SGTC_3219 9131112 49.47 µM 0.784929658864776 0.172261077437128 no 590 0.216247405779432 243 17612988 YMR079W SEC14 SGTC_1590 st077108 57.8 µM 0.78386352685359 0.17257648827941 no 591 0.216560096589817 214 5489485 SGTC_2600 tangeritin 87.95 µM 0.782668164036425 0.17293056915428 no 592 0.216911000976042 248 68077 A bioactive flavone. SGTC_694 1315-0438 43.2 µM 0.782445119754553 0.172996688768121 no 593 0.216976513042229 242 6793154 SGTC_1666 st014829 29 µM 0.781940184894874 0.173146431982288 no 594 0.217124863616861 235 3858230 SGTC_2879 9041815 71.43 µM 0.781509329549147 0.173274271468546 no 595 0.2172514958489 206 4942971 SGTC_1002 4049-0206 172 µM 0.78140766019343 0.173304446638657 no 596 0.217281383599403 255 4662749 SGTC_2041 5107442 45.335 µM 0.780902728674518 0.173454358416402 no 597 0.217429853545967 251 793005 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.78066152594734 0.173525999487123 no 598 0.217500797406828 224 521171 SGTC_2711 st079103 59.1 µM 0.779896910800732 0.173753226865784 no 599 0.217725778475373 234 54693780 SGTC_692 k241-0027 77.8 µM 0.778885390558015 0.174054119871503 no 600 0.218023615320251 236 3600480 SGTC_1347 1493-0251 600 nM 0.778191491287444 0.174260722839367 no 601 0.218228066090372 230 3986378 SGTC_3245 9134821 49.47 µM 0.777060583009998 0.17459777555432 no 602 0.218561514010991 261 17014901 SGTC_1244 0416-0015 52.5 µM 0.776166476923962 0.174864545234551 no 603 0.218825348401787 233 96201 SGTC_2898 9056270 58.44 µM 0.775926729750716 0.174936121283245 no 604 0.218896124562 198 19154699 SGTC_1339 1486-1321 22.7 µM 0.772863775905341 0.175852195654237 no 605 0.219801502388836 237 3469382 SGTC_1093 fluphenazine 7.97 µM 0.772767418416881 0.175881063653444 no 606 0.219830019508768 257 6602611 An atypical antipsychotic. SGTC_1012 4112-3522 18 µM 0.77164214098531 0.176218410704724 no 607 0.220163203953484 233 3112398 SGTC_2200 6600604 21.907 µM 0.770426012540365 0.176583454097992 no 608 0.22052361398295 274 2904777 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.769971180974639 0.176720102971458 no 609 0.220658494009253 271 229346 A bile salt which induces apoptosis. SGTC_3001 9076041 71.4286 µM 0.769887172340279 0.17674534970481 no 610 0.220683411888347 235 16004211 SGTC_3332 9141069 11.198 µM 0.768310810890276 0.177219509214987 no 611 0.221151276697858 245 17332883 SGTC_3107 9121808 49.47 µM 0.767854894754564 0.177356795533165 no 612 0.221286698546147 219 662681 SGTC_2920 7982904 15.77 µM 0.763800756905315 0.178580537002669 no 613 0.222492992854033 233 6456808 SGTC_408 cantharidin 100 µM 0.763480654578288 0.17867738587449 no 614 0.222588397627917 231 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1241 0364-0022 50.8 µM 0.760933711317593 0.179449156805883 no 615 0.223348330920477 245 4563895 SGTC_3262 9137218 49.47 µM 0.760472490904148 0.179589138902633 no 616 0.223486103301162 216 17650664 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.759751870077639 0.179807987311709 no 617 0.223701458616542 288 368090 SGTC_2797 7859098 81.82 µM 0.758652096481728 0.180142305017094 no 618 0.224030349894969 251 972681 SGTC_427 1354-0053 47.3 µM 0.757731673160305 0.180422402167182 no 619 0.224305816851356 246 6813657 SGTC_1607 st000305 50.6 µM 0.757087060433573 0.180618729047854 no 620 0.224498852850921 246 5457690 SGTC_1930 st074634 34.3 µM 0.756414760246265 0.180823631244442 no 621 0.224700280536542 251 684253 YOR116C RPO31 SGTC_2489 cantharidin 73.42 µM 0.755259243028315 0.181176147562342 no 622 0.225046724119938 248 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.754325654902026 0.181461273621946 no 623 0.225326850537719 256 551469 SGTC_834 0312-0008 75.7 µM 0.75207235586521 0.18215060740008 no 624 0.226003773629062 245 6385573 YIL048W NEO1 SGTC_3150 9097574 49.47 µM 0.750792371015438 0.182542910962038 no 625 0.226388810716012 235 17217476 SGTC_2744 captopril 92.04 µM 0.74894832035299 0.18310902247999 no 626 0.226944177359796 218 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_649 1123-0311 367 µM 0.748056437887685 0.183383217094742 no 627 0.227213058091574 256 693629 YIL048W NEO1 SGTC_2063 5246145 200 µM 0.746112617479888 0.183981699099081 no 628 0.227799693988408 248 711240 SGTC_2926 9010726 65.15 µM 0.745859222910399 0.184059806146271 no 629 0.227876230033391 262 2994293 SGTC_778 3456-2434 196 µM 0.74445716882682 0.184492352219065 no 630 0.228299972001755 229 5539063 SGTC_1787 fluconazole 80 µM 0.744412558359341 0.184506125312866 no 631 0.228313461862699 251 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2406 ethylparaben 405.7 µM 0.743937209632311 0.184652924808038 no 632 0.228457231464458 241 8434 A possible steroid mimic. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.743124557043332 0.184904060264395 no 633 0.228703136657041 235 4174840 SGTC_2983 9022671 12.99 µM 0.742540805821812 0.185084588861082 no 634 0.228879868958336 248 6405161 SGTC_2435 5706476 10.6 µM 0.742163950632335 0.185201191746388 no 635 0.228994003613647 233 5725375 SGTC_2742 clothiapine 36.27 µM 0.738804889507977 0.186242534559386 no 636 0.230012741173094 226 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3040 9091894 49.47 µM 0.738586120239027 0.186310480852063 no 637 0.230079177470142 223 25236966 SGTC_2685 mycophenolic acid 18.85 µM 0.736721357479681 0.186890270050535 no 638 0.230645908036239 246 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2803 7707263 71.43 µM 0.736575502765157 0.186935666007471 no 639 0.230690268429686 242 2199229 SGTC_2982 9019404 25.97 µM 0.735223431143738 0.187356810743967 no 640 0.231101715608265 237 22333232 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.734659511427489 0.187532634262971 no 641 0.231273442241684 283 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.733541209868402 0.187881608972448 no 642 0.231614201459311 273 688751 SGTC_730 1436-0052 41.2 µM 0.73223658992129 0.188289232194331 no 643 0.232012087412025 226 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_648 0375-0473 33.3 µM 0.73167097204349 0.188466126634898 no 644 0.232184709029086 262 1713139 SGTC_2151 5563267 85.4165 µM 0.7316505272914 0.188472522557598 no 645 0.232190949926376 281 5310824 SGTC_925 2064-1272 59.6 µM 0.729231764157307 0.189230151295239 no 646 0.232929952058643 252 6815817 SGTC_2994 9053520 71.4286 µM 0.729136266115065 0.189260102557799 no 647 0.232959156259089 246 4647384 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.727944266680104 0.18963419751379 no 648 0.233323851975684 258 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_377 3970-0964 33.1 µM 0.727701606694172 0.189710409175516 no 649 0.233398133301164 245 16481235 SGTC_116 0155-0182 31.788 µM 0.725565416076431 0.190382130224482 no 650 0.234052614385327 227 771486 SGTC_1383 3049-0032 20.7 µM 0.724588876490626 0.190689687129736 no 651 0.234352142505 273 712864 SGTC_2390 9097792 176.6 µM 0.723166322357262 0.191138259677175 no 652 0.23478885333401 250 4497149 SGTC_1667 st014849 34.6 µM 0.722610860735458 0.191313588321013 no 653 0.234959496908551 265 5348460 SGTC_1181 1222-0449 220 µM 0.721377593271486 0.191703215181293 no 654 0.235338614341096 272 658318 SGTC_3225 9130819 49.47 µM 0.719928610125068 0.192161613583731 no 655 0.235784475807053 289 4547121 SGTC_2950 9072895 21.46 µM 0.719810052217817 0.192199150062959 no 656 0.235820977441886 248 17332245 SGTC_38 0929-0051 58.268 µM 0.717233797724818 0.19301592229789 no 657 0.236614924142181 267 1379719 SGTC_1432 4049-0298 68.4 µM 0.715795676265512 0.193472782783126 no 658 0.237058761302651 268 741646 SGTC_1661 st013063 9.66 µM 0.715445711841081 0.19358405872605 no 659 0.237166837496854 281 721395 SGTC_1290 0986-0249 10.2 µM 0.715149901793532 0.193678145982379 no 660 0.237258210814455 280 53329 SGTC_2522 biochanin a 4.94 µM 0.71438961397386 0.19392009594108 no 661 0.237493146223986 248 5280373 A possible chelator. SGTC_3320 9137005 35.139 µM 0.713390724422409 0.194238257088608 no 662 0.23780200559799 259 4908713 SGTC_141 0443-0274 32.331 µM 0.711639058290775 0.19479695572396 no 663 0.238344157030316 237 1627241 SGTC_1519 esterone 74 µM 0.709447496553372 0.195497335131662 no 664 0.239023411062098 273 698 A steroid. SGTC_328 k915-0120 63.5 µM 0.708632491756592 0.195758184030935 no 665 0.239276283862027 248 6624543 SGTC_976 1348-1067 47.6 µM 0.707989770989917 0.195964040939245 no 666 0.239475804861693 270 5310671 YGL099W LSG1 SGTC_2206 7254556 146.969 µM 0.707888355670285 0.195996535224407 no 667 0.239507295703549 240 4398905 SGTC_1926 methyl fluorone black 53.6 µM 0.707180506627478 0.196223426771234 no 668 0.239727155449649 235 72721 Reacts with homocysteine. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.707075756730898 0.196257016472478 no 669 0.239759700390864 296 5393153 SGTC_1794 st048918 76.9 µM 0.706738915239537 0.196365053619624 no 670 0.239864370641799 229 672303 SGTC_2820 7989630 71.43 µM 0.705486682587165 0.196767005553929 no 671 0.240253708365239 224 2984098 SGTC_1235 benzylparaben 21.5 µM 0.704840883982072 0.196974493906185 no 672 0.240454631249849 275 7180 SGTC_2238 6671620 73.2395 µM 0.704525965336577 0.197075722001345 no 673 0.240552642908499 250 729941 SGTC_1534 6-azauridine 81.6 µM 0.703961171605492 0.19725734930325 no 674 0.240728477291264 268 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3089 9117425 49.47 µM 0.702959086597015 0.197579850567615 no 675 0.241040623434481 280 9401657 SGTC_837 0091-0265 12.5 µM 0.70057307004136 0.198349024796522 no 676 0.241784744745037 282 759367 SGTC_1765 st044815 90.4 µM 0.698478893166793 0.199025606159651 no 677 0.242438876590165 283 645695 SGTC_1739 st037196 92.5 µM 0.698312336170563 0.199079476605123 no 678 0.242490943041834 273 612214 SGTC_270 tamoxifen 5.46 µM 0.697613630109488 0.199305558657755 no 679 0.242709427620478 290 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2298 7976326 193.81 µM 0.696745820739036 0.199586573049394 no 680 0.242980938914507 246 2235818 SGTC_1552 6-methylflavone 10.6 µM 0.696394072433977 0.199700544210262 no 681 0.243091037092648 274 689013 SGTC_2960 9079389 5.97 µM 0.696334509988392 0.19971984711603 no 682 0.243109682970996 248 16457355 SGTC_3338 9144300 39.5675 µM 0.695904805507251 0.199859138340998 no 683 0.243244223824055 250 4901274 SGTC_3170 9103054 49.47 µM 0.695761727100039 0.199905531007807 no 684 0.243289030730142 278 16432970 SGTC_1369 1866-0067 208 µM 0.695171872618254 0.200096857606672 no 685 0.243473798601886 268 3531355 SGTC_192 3455-0609 60.9 µM 0.694851237453181 0.200200905752505 no 686 0.24357426716293 255 3769639 SGTC_1733 st037357 54.9 µM 0.694341409615471 0.200366415058828 no 687 0.243734063886605 274 1272339 YGL099W LSG1 SGTC_2196 6573537 42.6665 µM 0.694239017126971 0.200399665424109 no 688 0.243766163865473 287 2903087 SGTC_2126 5251174 33.877 µM 0.693811444045485 0.200538548935688 no 689 0.243900232407536 266 790722 SGTC_516 3992-2719 87.3 µM 0.692993759234347 0.200804308738193 no 690 0.244156733984922 258 5350887 YDR037W KRS1 SGTC_1950 st077106 7.18 µM 0.69264759529759 0.200916880851454 no 691 0.244265366817468 252 13831864 SGTC_108 0509-0257 621.132 µM 0.690798643143146 0.201518798936247 no 692 0.244846044192618 279 536624 SGTC_1726 st035556 14.5795 µM 0.689345284838766 0.201992690798701 no 693 0.245303003339329 255 5919439 SGTC_1400 3771-8998 51.5 µM 0.689204838691324 0.202038520938103 no 694 0.245347186137604 256 670767 SGTC_2479 5617353 43.85 µM 0.68848100163543 0.202274820841273 no 695 0.245574965050249 283 2731746 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.688173572287491 0.202375232547765 no 696 0.245671742066996 257 77254 SGTC_2915 7971052 15.16 µM 0.687680848294737 0.202536226827085 no 697 0.245826891494816 251 5741558 SGTC_2282 7944268 200 µM 0.687312934077858 0.202656490257972 no 698 0.245942774983774 278 2970414 SGTC_1402 3909-7673 35.9 µM 0.686134793539411 0.203041886701225 no 699 0.246314056011635 266 5328014 SGTC_584 0986-0246 15.4 µM 0.685519039547476 0.203243487791102 no 700 0.24650822516403 305 53315 YDR232W HEM1 SGTC_2142 5622915 118.518 µM 0.684881308208569 0.203452410271108 no 701 0.246709410975143 274 5322196 SGTC_2737 bleomycin 30.5 nM 0.68257637366406 0.204208580560564 no 702 0.247437283800726 274 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2891 9063876 19.48 µM 0.681412706788985 0.204590974856297 no 703 0.247805192408064 265 6472478 SGTC_1523 st012844 44.7 µM 0.681388261652294 0.204599012375319 no 704 0.247812924190669 282 4274103 SGTC_2217 6934799 96.0675 µM 0.680385743508614 0.204928800442046 no 705 0.248130122813034 266 675606 SGTC_1749 st037932 54.2 µM 0.679557111212084 0.205201625497397 no 706 0.248392467014213 294 594497 SGTC_2729 fluphenazine 10.66 µM 0.678298389097959 0.205616469177072 no 707 0.248791259930918 282 3372 An atypical antipsychotic. SGTC_3190 9110366 49.47 µM 0.677712638065599 0.205809687849207 no 708 0.248976955862709 254 17123768 SGTC_1375 2910-0797 186 µM 0.677340638778959 0.205932453251068 no 709 0.249094926083616 288 742508 SGTC_3176 9106582 49.47 µM 0.675289469035434 0.206610150042697 no 710 0.249745936642527 245 17018027 SGTC_2212 7123476 200 µM 0.674057647420252 0.207017772113866 no 711 0.250137332146556 258 1085715 SGTC_2707 st078556 66.6 µM 0.672425186602498 0.207558702212164 no 712 0.250656526485953 273 17250899 SGTC_416 estradiol valerate 100 µM 0.672022990425887 0.207692101548899 no 713 0.250784530141391 289 13791 A steroid. SGTC_1972 st070201 17.4 µM 0.671415244537641 0.207893773122317 no 714 0.250978018049397 275 2829099 SGTC_2774 tamoxifen 10.92 µM 0.669837012269572 0.208418026133194 no 715 0.251480848174516 284 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2505 galangin 7.89 µM 0.668504123346443 0.208861388348399 no 716 0.251905925370368 289 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1877 wortmannin 25 µM 0.66823490247429 0.20895100737468 no 717 0.251991829739525 283 312145 A covalent inhibitor of PI 3-kinase. SGTC_2130 NSC 7 2.4545 µM 0.667505422159001 0.20919395271266 no 718 0.252224673706923 267 21448 SGTC_733 4069-0007 56.1 µM 0.665235404467345 0.209951020067408 no 719 0.252949969446027 284 5717425 YNL287W SEC21 SGTC_2107 5363541 170.161 µM 0.662997208421445 0.210699048743025 no 720 0.253666170980171 271 244052 SGTC_891 0929-0073 133 µM 0.662830431951185 0.210754849715633 no 721 0.253719580473829 293 5603632 SGTC_1416 3966-0321 25.3 µM 0.662528289077012 0.21085596438567 no 722 0.253816355551207 278 582530 YLR208W SEC13 SGTC_2890 9046729 58.44 µM 0.66251006372564 0.210862064563399 no 723 0.253822193673352 290 903329 SGTC_1390 3413-2614 145 µM 0.662238162062531 0.210953084615617 no 724 0.253909300233687 307 3421432 SGTC_1616 st002734 56.1 µM 0.662200074955113 0.21096583624985 no 725 0.253921503092133 276 4026101 SGTC_465 cgp-37157 41 µM 0.661895991790423 0.211067660063253 no 726 0.254018940372959 257 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_98 0074-0023 107.663 µM 0.661576411816847 0.211174704102218 no 727 0.254121364429794 279 3563821 SGTC_2641 levomentholum 100 µM 0.661322412358013 0.21125980448387 no 728 0.2542027856508 286 16666 SGTC_1689 st020265 53.493 µM 0.66024274524299 0.211621762012943 no 729 0.254549032749058 288 5758320 YPR016C TIF6 SGTC_2180 6301957 200 µM 0.658256407551568 0.212288627602118 no 730 0.255186692119073 287 845462 SGTC_2691 st077356 60.2 µM 0.657538502606652 0.212529948931616 no 731 0.255417361191272 305 2839272 SGTC_602 3130-1533 38.1 µM 0.6564193313283 0.212906474028999 no 732 0.255777177824242 301 720941 SGTC_1467 k284-1082 293 µM 0.656392551195897 0.212915488490621 no 733 0.255785790950695 298 3334705 SGTC_206 4546-0025 72.014 µM 0.655857146503343 0.213095757825745 no 734 0.255958021580047 303 6620745 YIL048W NEO1 SGTC_3230 9131665 49.47 µM 0.655068167744849 0.213361567081048 no 735 0.256211932933254 287 15943720 SGTC_2556 citropten 84.59 µM 0.654392997225991 0.213589187410156 no 736 0.256429322431552 247 2775 A potential DNA crosslinker. SGTC_1579 chlormadinone acetate 49.4 µM 0.654266228206398 0.213631940838285 no 737 0.256470149876785 303 45114258 A steroidal progestin. SGTC_2754 granisetron 64.02 µM 0.65308632130667 0.214030108899988 no 738 0.256850315083706 295 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_33 0986-0033 35.816 µM 0.652692433370127 0.214163125319131 no 739 0.256977290772001 254 2848082 SGTC_3027 9089541 49.47 µM 0.652524746159763 0.214219768081839 no 740 0.257031357169867 283 9943819 SGTC_835 0312-0010 67.2 µM 0.652351594632735 0.214278265771715 no 741 0.257087191603703 295 1626196 SGTC_1976 st070609 63.5 µM 0.651584238507322 0.214537621968903 no 742 0.257334709125271 282 682556 SGTC_183 3914-0051 30.55 µM 0.651576939650915 0.214540089761453 no 743 0.25733706403057 274 1596232 SGTC_124 0136-0217 7.121 µM 0.650399327189924 0.214938464544316 no 744 0.257717155901147 283 3976905 SGTC_2713 st079149 53.4 µM 0.650282446316853 0.214978027624408 no 745 0.257754896826892 286 3103253 SGTC_232 clozapine 119 µM 0.650191865868659 0.215008691165663 no 746 0.257784147297807 277 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3277 9138724 49.47 µM 0.64977594357526 0.215149522920534 no 747 0.257918480107141 272 15943418 SGTC_2286 7945697 125 µM 0.649504887800431 0.215241331522558 no 748 0.258006044088445 281 1245733 SGTC_2902 5787006 60.46 µM 0.648758688579728 0.215494192157866 no 749 0.258247181762153 287 591003 SGTC_2008 4012253 172 µM 0.646993808033087 0.216092933219577 no 750 0.258817975470513 283 603940 SGTC_1269 0831-0796 3.05 µM 0.646647788936486 0.216210434114267 no 751 0.258929960685915 284 927758 SGTC_344 k064-0035 6.43 µM 0.645397558791023 0.21663529448655 no 752 0.259334792501621 281 5088750 SGTC_2525 harmine 47.85 µM 0.644753917731776 0.216854208447447 no 753 0.259543334679334 271 5280953 A monoamine oxidase inhibitor SGTC_1851 st056236 18.9 µM 0.642901753126325 0.21748487618429 no 754 0.260143925897311 268 5393171 SGTC_1415 3966-0071 78.1 µM 0.641708811431065 0.217891636452437 no 755 0.260531133481577 292 2893185 SGTC_2988 9073640 71.4286 µM 0.641000773650419 0.218133265163308 no 756 0.260761090157195 302 9102229 SGTC_2204 7233102 200 µM 0.640923429487592 0.218159669393794 no 757 0.260786216338154 283 2172480 SGTC_2523 spermine 47.74 µM 0.640150834180949 0.218423523854449 no 758 0.261037271559163 259 1103 A DNA binding polyamine. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.640133275915503 0.218429522436449 no 759 0.261042978569747 285 803109 SGTC_1127 asiatic acid 681.4 nM 0.640059817995762 0.218454619529342 no 760 0.261066855491936 293 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_359 0081-0058 15.9 µM 0.639891761532589 0.218512042710426 no 761 0.261121485152751 317 3494159 SGTC_617 3770-0098 35 µM 0.638858940459121 0.21886513794085 no 762 0.261457350478812 292 5962639 SGTC_1724 st037281 8.293 µM 0.638370832511514 0.219032123782846 no 763 0.261616156515072 285 574124 YDL195W SEC31 SGTC_959 1222-0044 107 µM 0.637483199307112 0.219335978278968 no 764 0.261905075005436 288 6083612 SGTC_1055 3448-0672 86 µM 0.636947105136391 0.219519611244456 no 765 0.262079649180243 279 748378 SGTC_2541 muurolladie-3-one 83.07 µM 0.636319364342218 0.219734748925158 no 766 0.26228414302016 302 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_953 1188-0045 9.7 µM 0.636303317303104 0.219740250110647 no 767 0.26228937160031 299 6144426 SGTC_2871 9038510 12.99 µM 0.635228923076141 0.220108749719484 no 768 0.262639561098118 313 4945164 SGTC_1207 2099-0101 141 µM 0.632635480085382 0.220999717150833 no 769 0.263485856008789 290 5837381 SGTC_2651 TUB2.036 5 µM 0.632564951876439 0.221023975643374 no 770 0.263508890269568 291 15992207 YFL037W TUB2 SGTC_657 3534-0529 86.7 µM 0.632292225458773 0.221117795452114 no 771 0.263597971411785 303 1049549 SGTC_919 tnp00227 403.569 nM 0.631146479093797 0.221512189130455 no 772 0.263972376492454 322 1269246 A methoxyflavone. YNL221C POP1 SGTC_3214 9129694 49.47 µM 0.630989569888617 0.221566232371371 no 773 0.264023672112408 302 17158655 SGTC_2545 solidagenone 89.61 µM 0.630769271345485 0.221642121115512 no 774 0.26409569908618 255 6708572 An anti ulcer agent SGTC_535 2293-4129 48.2 µM 0.629952520914253 0.221923606005905 no 775 0.264362824322635 315 396118 YIL048W NEO1 SGTC_1205 4161-2785 76 µM 0.629865027424364 0.221953771865455 no 776 0.264391447973347 283 3498106 SGTC_2121 5257820 149.641 µM 0.628321078066401 0.222486477218902 no 777 0.26489681315659 271 791256 SGTC_3209 9113616 49.47 µM 0.620398935051609 0.225231277370691 no 778 0.267497586691448 301 16649353 SGTC_1294 1000-1494 117 µM 0.62025662799754 0.225280757495715 no 779 0.267544422369485 286 712797 YDL207W GLE1 SGTC_3162 9099653 49.47 µM 0.620198716835878 0.225300894953483 no 780 0.267563483103814 269 25237511 SGTC_1065 prochlorperazine maleate 2.48 µM 0.619251996236455 0.225630242775712 no 781 0.267875181392691 314 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_722 3534-0461 190 µM 0.617687002043322 0.226175274267961 no 782 0.268390840826514 284 658262 SGTC_3111 9122088 49.47 µM 0.615845110893212 0.226817691048105 no 783 0.268998375540992 285 16876704 SGTC_2329 6138490 200 µM 0.614311307954957 0.227353437107506 no 784 0.269504815773119 324 720019 SGTC_1987 st072290 61.9 µM 0.613327584128468 0.227697419512615 no 785 0.269829878925678 309 54697379 SGTC_511 blebbistatin 171 µM 0.613239351253791 0.227728286543499 no 786 0.269859044317158 301 3476986 A myosin inhibitor. SGTC_1982 st072467 71.9 µM 0.612463613972084 0.227999768686982 no 787 0.270115532319655 310 3163533 SGTC_220 paclitaxel 373.376 µM 0.611260273796391 0.228421257561123 no 788 0.270513643119725 292 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1974 st069448 26.9 µM 0.610947589129391 0.228530851916492 no 789 0.270617139090864 279 6323587 YNR016C ACC1 SGTC_223 busulfan 5 mM 0.610240303758633 0.228778860710889 no 790 0.27085131748444 289 2478 A DNA alkylator. SGTC_3349 9149703 23.001 µM 0.610038321187775 0.228849713390282 no 791 0.270918211391404 293 4910494 SGTC_2316 5844804 197.44 µM 0.609260249403444 0.229122765233351 no 792 0.271175975307758 299 776813 SGTC_2384 9036245 200 µM 0.608900137899499 0.229249202435662 no 793 0.27129531641486 272 6462766 SGTC_425 3825-7017 13.1 µM 0.606054884536116 0.230249561650049 no 794 0.272239154082309 304 3397440 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.605518777696757 0.230438323780809 no 795 0.27241717589486 301 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3330 9141424 71.43 µM 0.605427828191184 0.230470355497928 no 796 0.272447382692153 285 27261020 SGTC_3065 9113888 49.47 µM 0.605393227734533 0.230482542166431 no 797 0.272458874878922 309 16648368 SGTC_1446 4239-0190 62 µM 0.60434155971798 0.230853123231439 no 798 0.272808290437265 317 1340085 SGTC_67 0335-0847 266 µM 0.604061228167345 0.23095196107908 no 799 0.27290146780107 330 4552207 YOR254C SEC63 SGTC_2312 7706453 155.7 µM 0.603797237979039 0.231045058968991 no 800 0.272989228005257 305 976098 SGTC_289 k017-0060 526 µM 0.6035225256075 0.231141960343876 no 801 0.273080567517433 300 5512909 SGTC_2143 5623677 140.463 µM 0.602886942521546 0.231366241286468 no 802 0.273291951500306 293 5375313 SGTC_2495 cafestol 54.53 µM 0.602365816190113 0.231550223896296 no 803 0.273465329585633 312 16667697 An anti-infammatory. SGTC_2497 7-hydroxyflavone 100 µM 0.601303531491143 0.23192551382506 no 804 0.273818918929254 335 5281894 SGTC_2932 9016711 44.54 µM 0.599758334151996 0.232472014074842 no 805 0.274333652594139 314 7117328 SGTC_2402 5553605 200 µM 0.599083063532377 0.232711066218289 no 806 0.27455874756278 308 6758546 SGTC_685 1278-0033 54.9 µM 0.599046569070478 0.232723989490781 no 807 0.274570915235526 313 3590572 SGTC_2995 9067767 71.4286 µM 0.598847924514823 0.232794339697825 no 808 0.274637150276231 296 11673567 SGTC_1654 st012436 41.8 µM 0.5956687607116 0.23392185086373 no 809 0.275698265697664 305 4323132 SGTC_184 1494-0393 24.714 µM 0.59323562762681 0.234786817269483 no 810 0.276511736181341 307 3090647 SGTC_1653 st012112 65 µM 0.587466899085454 0.236844618416694 no 811 0.278445087546856 316 720429 SGTC_770 0389-1121 67.2 µM 0.586952760027142 0.237028500420535 no 812 0.278617717022427 304 6753108 SGTC_1134 3477-0009 42.5 µM 0.585548869404288 0.237531001745201 no 813 0.279089358484001 331 3973534 SGTC_1233 0325-0408 14.2 µM 0.585499601097636 0.237548647200598 no 814 0.279105917374683 321 12874 SGTC_2770 toltrazuril 17.5 µM 0.585095593251753 0.237693369837712 no 815 0.279241720892878 291 68591 Kills coccidiodes. SGTC_1620 st003704 16.5 µM 0.581663577706804 0.238924726176987 no 816 0.280396654643657 307 2834414 SGTC_1935 st074532 41.6 µM 0.581081481612554 0.239133919079138 no 817 0.280592769402624 312 2829742 SGTC_2958 9077254 16.72 µM 0.580521565504308 0.239335235386044 no 818 0.280781474076155 294 16457351 SGTC_2158 5657123 3.6195 µM 0.57824649686481 0.240154181586339 no 819 0.281548855443952 349 2858827 SGTC_296 1222-0039 74.9 µM 0.57771450965851 0.24034589871756 no 820 0.281728440719645 294 5984176 SGTC_2119 5528445 120.635 µM 0.575941168311166 0.240985575857118 no 821 0.28232747391485 307 791935 SGTC_3125 9127534 49.47 µM 0.575786108349399 0.241041552849346 no 822 0.282379882158125 293 1639235 SGTC_273 hydroxyurea 18.1 mM 0.574139016865268 0.241636592759193 no 823 0.282936866256868 324 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1406 3909-7906 11.9 µM 0.573789910430906 0.241762815766379 no 824 0.283054988577827 323 X1406 SGTC_2193 5925765 200 µM 0.57354333046288 0.241851990838426 no 825 0.283138434695328 294 877370 SGTC_2666 tannic acid 100 µM 0.57294275744301 0.242069261325125 no 826 0.28334172639576 306 16134267 A thiamine antagonist. SGTC_1866 st057638 64 µM 0.571394975291309 0.242629693089449 no 827 0.283865967189709 306 688802 SGTC_3095 9117207 49.47 µM 0.570036144028931 0.2431222867382 no 828 0.284326591853601 305 17015229 SGTC_1423 4048-0112 5.59 µM 0.569442806714112 0.243337548575313 no 829 0.284527836836634 311 X1423 SGTC_3062 9077494 49.47 µM 0.568161670528739 0.243802693844971 no 830 0.284962597654209 268 16459633 SGTC_1343 1487-0095 224 µM 0.567286515243056 0.244120714304097 no 831 0.285259768574454 335 4560101 YGL055W OLE1 SGTC_1313 1220-0047 237 µM 0.567286098735999 0.24412086571078 no 832 0.285259910040254 307 3528706 SGTC_3287 9117173 37.0625 µM 0.567221357917131 0.244144400604073 no 833 0.285281899538073 292 2789709 SGTC_1010 4112-3296 15.2 µM 0.565433715060662 0.244794736169601 no 834 0.285889398901971 305 704384 SGTC_2741 miltefosine 3.04 µM 0.564664002661057 0.245075040632239 no 835 0.286151161579318 307 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2986 9022445 71.43 µM 0.562919186316547 0.2457110852621 no 836 0.286744957374829 333 6459286 SGTC_3091 9116372 49.47 µM 0.562025669566848 0.246037145215321 no 837 0.287049264937279 302 17169793 SGTC_3334 9142812 21.919 µM 0.560528650234578 0.246583953686541 no 838 0.287559451606109 325 45283678 SGTC_1573 oleylamine 1.06 µM 0.558718264517292 0.24724609253085 no 839 0.288177006135314 324 5356789 An amine of the fatty acid oleic acid. SGTC_932 2857-0803 154 µM 0.558606304221156 0.247287072599296 no 840 0.288215218303436 322 674898 SGTC_3031 9088762 49.47 µM 0.558420732478873 0.247355004163337 no 841 0.288278559399717 314 205253 SGTC_2862 9027634 71.43 µM 0.558295259388634 0.247400941287072 no 842 0.288321390777327 295 5012562 SGTC_2038 4100038 30.985 µM 0.557521832693638 0.247684202234239 no 843 0.288585473229111 301 3596803 SGTC_2724 maprotiline 69.64 µM 0.556733449791738 0.247973118927924 no 844 0.288854779620418 334 4011 A tricyclic antidepressant. SGTC_3266 9136860 49.47 µM 0.556687949107777 0.247989798936182 no 845 0.288870325963249 319 4871271 YPR165W RHO1 SGTC_1086 cerivastatin 2.18 µM 0.556583027149937 0.248028264356889 no 846 0.2889061764358 291 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_264 promethazine 12.5 mM 0.555707748522273 0.248349274108069 no 847 0.289205329351327 335 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_490 phenamil 164 µM 0.555637238944776 0.248375143237211 no 848 0.289229434466315 317 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2703 st077852 53.4 µM 0.554856025056174 0.248661857453842 no 849 0.289496571300692 324 6281836 SGTC_1138 3761-0006 1.03 µM 0.554015949263119 0.248970371238461 no 850 0.289783965253413 313 12061087 SGTC_52 0329-0193 875 nM 0.553488851251456 0.249164049389641 no 851 0.289964356324264 352 3739292 SGTC_2913 7966556 36.57 µM 0.55303622839426 0.249330426140953 no 852 0.290119301442107 304 2976516 SGTC_1186 1319-0216 26 µM 0.552334972146544 0.24958831304735 no 853 0.290359437130621 316 4565136 SGTC_3119 9125183 49.47 µM 0.552212522371071 0.249633358465978 no 854 0.290401377937751 296 22695334 SGTC_634 1611-4317 11.2 µM 0.551243315720274 0.249990051396515 no 855 0.290733445165725 347 2843522 SGTC_1464 k208-0027 110 µM 0.551191014302618 0.250009307349053 no 856 0.290751369598867 326 X1464 SGTC_362 0310-0100 9.03 µM 0.550663968909913 0.250203394975695 no 857 0.290932024319247 289 790235 SGTC_3021 9087658 49.47 µM 0.549772074481832 0.250532022388463 no 858 0.291237857343118 322 25237042 SGTC_968 1309-0633 340 µM 0.549380291201269 0.250676451114091 no 859 0.29137224832183 325 3761976 SGTC_2515 chrysin 20.77 µM 0.549233339608402 0.250730635370833 no 860 0.291422663672716 311 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1796 st049173 110.4 µM 0.548059400178952 0.251163715019178 no 861 0.291825558443352 343 94134 SGTC_2751 anetholtrithion 17.25 µM 0.546016423009487 0.251918334965847 no 862 0.292527324100325 330 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2226 7298446 200 µM 0.545893498329314 0.251963778119725 no 863 0.292569573910813 334 3283010 SGTC_784 4579-0127 173 µM 0.545891246084946 0.251964610776339 no 864 0.292570348044609 328 1948547 SGTC_167 3672-0051 66.205 µM 0.544176299758175 0.252599049135425 no 865 0.2931600796555 330 3237971 SGTC_89 0302-0250 142.109 µM 0.544027272088771 0.252654221111328 no 866 0.29321135295191 329 4203518 YLR208W SEC13 SGTC_24 0417-1663 219 µM 0.543285129664794 0.25292906633701 no 867 0.293466750562772 339 4329390 SGTC_870 0573-2213 57.6 µM 0.542293289622038 0.253296630170482 no 868 0.293808238795869 309 3916321 SGTC_654 1124-0271 80.9 µM 0.54053515804896 0.253948861745327 no 869 0.29441401075658 328 5403748 SGTC_1674 st016616 23.6 µM 0.540434021321863 0.253986408233368 no 870 0.294448875392068 312 625830 SGTC_505 gw-5074 63.9 µM 0.539803610857876 0.254220510513406 no 871 0.29466623831766 323 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1275 0867-0008 21.1 µM 0.538744759805401 0.254613968235906 no 872 0.295031492242673 326 3422836 SGTC_2839 9003951 25.97 µM 0.537539130504246 0.255062355220083 no 873 0.295447631517059 306 2990634 SGTC_2252 omeprazole 400 µM 0.53724176078766 0.255173013805472 no 874 0.295550314193372 312 4594 A proton pump inhibitor. SGTC_725 1497-0963 19 µM 0.537105701193344 0.255223653297037 no 875 0.295597301459938 327 3549977 SGTC_310 1273-0058 1.06 µM 0.537070087349145 0.255236909142922 no 876 0.295609601028776 297 2734232 SGTC_2805 7950783 58.44 µM 0.53643746152821 0.2554724390768 no 877 0.295828123373816 332 1178958 YDL195W SEC31 SGTC_2916 7875993 68.79 µM 0.52627032463208 0.259273239161845 no 878 0.299350199209554 354 1299250 SGTC_501 nsc-95397 161 µM 0.526121044575378 0.259329261691548 no 879 0.299402053860663 335 262093 SGTC_3339 9145883 14.936 µM 0.524913505510348 0.259782662514581 no 880 0.299821660188323 324 2030670 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.524832995013993 0.259812906738218 no 881 0.299849646151451 362 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1318 1280-3875 124 µM 0.523020451232532 0.260494279601773 no 882 0.300480010701944 334 373245 SGTC_1865 st057639 52.2 µM 0.521539771887521 0.261051579811566 no 883 0.300995403549798 338 688818 SGTC_562 3772-2733 112 µM 0.520677702696433 0.261376328733417 no 884 0.301295654859121 339 2876874 YIL048W NEO1 SGTC_161 4065-0411 162.148 µM 0.520012278432048 0.261627141626809 no 885 0.301527508618989 342 1906281 YLR208W SEC13 SGTC_2219 9098279 200 µM 0.519650871420227 0.261763415541347 no 886 0.301653467285489 313 902349 SGTC_2020 4017018 200 µM 0.519558617781506 0.261798206987481 no 887 0.301685623593835 344 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2190 6049624 200 µM 0.519056452126803 0.261987629391281 no 888 0.301860687547364 334 2265554 SGTC_948 3448-0295 75.3 µM 0.515516099429569 0.263325080390119 no 889 0.303096211203039 320 678569 SGTC_151 3013-0144 2.285 µM 0.51448345736409 0.263715840816587 no 890 0.303457011624864 355 906558 YHR107C CDC12 SGTC_1805 st050013 60.3 µM 0.51379847266983 0.263975207839944 no 891 0.303696447941535 335 4037144 SGTC_487 nimodipine 119 µM 0.512340583799261 0.264527664764511 no 892 0.304206333303683 337 4497 L-type voltage-gated calcium channels inhibitor SGTC_1664 st014217 9.02 µM 0.512008642877071 0.264653533656829 no 893 0.304322480352905 353 3982782 SGTC_1758 st042942 75.2445 µM 0.511651792668841 0.264788881885738 no 894 0.304447365249508 323 669317 SGTC_2061 5245884 80.95 µM 0.511224995094399 0.264950806362132 no 895 0.304596759185397 360 573863 SGTC_3033 9090887 49.47 µM 0.510691613707184 0.265153238819802 no 896 0.304783506973569 327 19325384 SGTC_1830 st055982 50.3 µM 0.509603296780514 0.265566527612365 no 897 0.305164706868112 364 455313 An antimicrobial agent. SGTC_2269 7935389 174.42 µM 0.508783964725003 0.265877884737499 no 898 0.305451830188475 348 97605 SGTC_2688 kanamycin b 96.69 µM 0.506029522495155 0.266925964078346 no 899 0.306417962384769 317 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_839 0122-0028 230 µM 0.50590958872201 0.266971646861116 no 900 0.306460060314764 349 759448 SGTC_2056 5235370 200 µM 0.505456420837517 0.267144294182097 no 901 0.306619149740883 322 5511916 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.505257929875098 0.26721993276092 no 902 0.306688843592233 339 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1988 st071872 53.4 µM 0.505160482395062 0.267257070844736 no 903 0.306723061764715 320 16414116 SGTC_1003 4049-0218 100 µM 0.504865126573546 0.267369649430784 no 904 0.306826784704306 338 295161 SGTC_51 1013-0126 23.419 µM 0.500883289115592 0.268889708314279 no 905 0.308226631955506 357 1627850 SGTC_910 3454-3003 490 µM 0.500373012525668 0.269084818645743 no 906 0.308406226197981 345 820824 SGTC_2024 5144227 134 µM 0.499712344983532 0.269337538244445 no 907 0.308638819365255 335 3475211 SGTC_3073 9114972 49.47 µM 0.499098164279291 0.269572582324647 no 908 0.308855115365751 339 41905075 SGTC_1663 st014140 55.4 µM 0.499030035099542 0.269598661374179 no 909 0.308879112504011 345 4207120 SGTC_1330 1469-0054 61.8 µM 0.498112877433133 0.269949861556727 no 910 0.309202242299664 361 7102664 SGTC_5 0352-0601 109.883 µM 0.49713203429005 0.270325701537792 no 911 0.309547972925643 332 762456 SGTC_506 n9-isopropylolomoucine 153 µM 0.496549273602548 0.270549127892186 no 912 0.309753466087131 351 6610355 SGTC_338 4055-0136 114 µM 0.496302409862147 0.27064380152501 no 913 0.309840533152049 330 2900563 SGTC_791 1348-1292 225 µM 0.496213867818917 0.270677761927471 no 914 0.309871763893115 336 5437054 SGTC_949 1165-0505 146 µM 0.496113867287056 0.270716119805124 no 915 0.309907037947108 315 6244267 SGTC_941 3237-0776 460 µM 0.495199924185048 0.271066812822209 no 916 0.310229502068737 349 760008 SGTC_558 k064-0027 21.3 µM 0.495159987217712 0.271082142372197 no 917 0.310243596253259 332 5088526 SGTC_1281 0884-0031 11.8 µM 0.492954012477712 0.271929562633933 no 918 0.311022540835038 344 1548255 SGTC_2002 4023503 131 µM 0.492449971717101 0.27212337354218 no 919 0.311200640083637 379 4736863 YCR052W RSC6 SGTC_398 bronopol 33.3 µM 0.49131818800374 0.272558810685785 no 920 0.311600708921476 347 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_469 w7 172 µM 0.490719819315309 0.272789163943198 no 921 0.311812313370269 344 45115570 A P450 inhibitor. SGTC_1338 1486-1223 76 µM 0.489741767113013 0.273165891325235 no 922 0.312158321186962 341 3444526 SGTC_2608 thymoquinone 42.66 µM 0.489212569378494 0.273369835801617 no 923 0.312345605838474 340 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_225 nsc-122657 1.016 µM 0.488901351634962 0.273489809420515 no 924 0.312455769370388 347 275685 SGTC_2708 st078559 56 µM 0.4869357861025 0.274248131323195 no 925 0.313151918820805 325 17250902 SGTC_1355 1499-0035 1.68 µM 0.486451820039829 0.274435006264556 no 926 0.313323428690841 354 1548538 SGTC_1882 5615643 20 µM 0.485545068537888 0.274785301420332 no 927 0.313644875675872 322 2253075 SGTC_1876 myriocin 605 nM 0.485127746873446 0.274946594663417 no 928 0.31379286543095 376 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1283 0922-0125 16.4 µM 0.484902414842084 0.275033704030655 no 929 0.313872784673783 349 3360884 SGTC_2474 5321570 43.32 µM 0.484723136341824 0.275103019629129 no 930 0.313936376199383 370 2841384 SGTC_42 0133-0086 60.653 µM 0.483261629046862 0.275668412325394 no 931 0.314454990610568 366 162923 Model of phenazepam hydroxylation. SGTC_601 0986-0029 62.9 µM 0.481287290601131 0.27643310271112 no 932 0.315156164329273 348 24747981 SGTC_32 0928-0142 34.1 µM 0.480654880167542 0.276678264381953 no 933 0.315380901921561 360 2244242 SGTC_1004 4084-0029 199 µM 0.480262282984866 0.276830513084292 no 934 0.315520452254153 366 716894 YLR208W SEC13 SGTC_1611 st001856 99.4 µM 0.48012658403269 0.276883146511305 no 935 0.315568693142356 384 647478 SGTC_3124 9127567 49.47 µM 0.477990548555801 0.277712293699899 no 936 0.316328466043481 337 17592030 SGTC_1705 st027868 56.3335 µM 0.474993017367797 0.278877889674131 no 937 0.317395975132445 367 292948 SGTC_652 0437-0092 114 µM 0.4746274038345 0.279020221936205 no 938 0.31752628509633 325 3091274 SGTC_2532 xanthone 78.9 µM 0.474523847911873 0.279060542368712 no 939 0.317563198038879 342 7020 An insecticide. SGTC_810 3825-7150 143 µM 0.473157450015524 0.279592826890586 no 940 0.318050426050392 324 22330411 YGL099W LSG1 SGTC_704 1310-0270 142 µM 0.472738330127015 0.279756195056855 no 941 0.318199938343387 362 5718033 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.472142053280504 0.279988696777444 no 942 0.318412698744403 345 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2436 5633522 8.09 µM 0.47213378556071 0.279991921205253 no 943 0.318415649210362 343 5724242 SGTC_2847 9005661 71.43 µM 0.468302923466925 0.28148789880789 no 944 0.319783989048009 336 2991449 SGTC_1827 berberine 7.24 µM 0.468011710928464 0.281601776799679 no 945 0.319888107498754 345 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_333 3486-0131 40.1 µM 0.467399897377695 0.281841097425899 no 946 0.32010689800412 358 6744690 SGTC_1715 st032160 10.2275 µM 0.467106455752601 0.281955916563662 no 947 0.32021185780474 352 5289825 SGTC_2859 9028643 45.46 µM 0.467067337008077 0.281971224821097 no 948 0.32022585109761 323 17151580 SGTC_2365 9042475 200 µM 0.467017447535623 0.281990748546069 no 949 0.320243697593428 336 6464479 SGTC_3319 9138450 16.7555 µM 0.464653984310728 0.282916410504856 no 950 0.32108963309545 363 2029690 SGTC_639 0833-0042 114 µM 0.464249377848817 0.283075022759901 no 951 0.321234543938115 359 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1291 0993-0025 5.79 µM 0.463710123314379 0.283286485550009 no 952 0.321427721648962 352 4353356 SGTC_3142 9086498 49.47 µM 0.463373632555159 0.283418475109499 no 953 0.321548287563747 349 25236367 SGTC_642 0335-0876 158 µM 0.463012825051987 0.283560035733244 no 954 0.321677587147021 353 6812350 SGTC_2466 5983409 37.09 µM 0.462692461453073 0.283685756826662 no 955 0.321792411291107 358 2879657 SGTC_1114 scopoletin 1.73284 µM 0.461357834200862 0.284209795040794 no 956 0.322270949045737 368 5280460 A coumarin with genotoxic properties. SGTC_1062 mesoridazine 14.2 µM 0.459610491928466 0.28489658367452 no 957 0.32289791343612 349 4078 A neuroleptic. SGTC_268 camptothecin 39.6153 µM 0.459231188934291 0.285045772307506 no 958 0.323034077845806 349 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1035 k081-0041 55.2 µM 0.458873478519575 0.28518650219926 no 959 0.323162512558354 371 731709 SGTC_2595 hexamethylquercetagetin 100 µM 0.457634587719082 0.28567416050531 no 960 0.323607494979965 390 386331 SGTC_3297 9117502 71.43 µM 0.45684539926533 0.285985011476282 no 961 0.323891085788499 322 7453720 SGTC_1353 1498-1206 8.11 µM 0.455471203752891 0.286526672412969 no 962 0.324385139857924 346 6756808 SGTC_337 1315-0038 354 µM 0.455185314903364 0.286639421164347 no 963 0.324487962198428 381 1626437 SGTC_3195 9113082 49.47 µM 0.454554041141402 0.28688845720119 no 964 0.324715052527607 349 17018038 SGTC_2331 7980721 200 µM 0.453213730827735 0.287417546164469 no 965 0.325197423060848 358 2981221 SGTC_341 1486-1430 230 µM 0.45298348898615 0.287508480813216 no 966 0.325280315390416 366 2054753 YPL210C SRP72 SGTC_113 0099-0221 2.5 µM 0.452785784683163 0.287586575525914 no 967 0.325351500361335 366 89219 SGTC_246 cycloheximide 667 µM 0.45114886423244 0.288233556531733 no 968 0.325941130896055 355 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2199 6590217 200 µM 0.451116458980137 0.288246371401071 no 969 0.325952807902481 361 703109 SGTC_696 1560-0013 611 µM 0.450019186211593 0.288680453627699 no 970 0.326348303171194 334 1650269 SGTC_894 0960-0238 55.9 µM 0.448668635661085 0.289215155077563 no 971 0.326835356700988 364 6741907 YDL195W SEC31 SGTC_1833 st055984 71 µM 0.448178054791745 0.289409497968451 no 972 0.327012349641411 352 676288 SGTC_1201 1889-3372 45.9 µM 0.447959782067297 0.28949598610368 no 973 0.327091111109832 341 5392199 SGTC_883 0850-0245 24.6 µM 0.44778261949766 0.289566193721377 no 974 0.327155044063997 361 6823229 YPR165W RHO1 SGTC_2325 6158266 200 µM 0.447583399552578 0.289645151987397 no 975 0.327226942958779 335 3623240 SGTC_1801 st050089 28.441 µM 0.446750963205694 0.28997518673128 no 976 0.327527440315713 340 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3261 9137475 49.47 µM 0.446060402875327 0.290249105844644 no 977 0.327776807332686 344 17027690 SGTC_2192 5915882 198.485 µM 0.44592525257951 0.29030272902393 no 978 0.327825620208491 349 2876149 SGTC_3286 9117135 37.221 µM 0.445626068573103 0.290421451869908 no 979 0.327933688384162 350 3438150 SGTC_559 1550-0661 158 µM 0.445442537476132 0.290494292324292 no 980 0.327999988734214 372 5830875 SGTC_99 0109-0120 622.8 µM 0.443681601077438 0.29119361303407 no 981 0.328636399770251 376 759414 SGTC_2387 9077560 195.08 µM 0.443524307821849 0.291256117129961 no 982 0.328693270546367 343 5303272 SGTC_967 1306-0166 352 µM 0.442925968496472 0.291493938238076 no 983 0.328909641696338 369 4437607 SGTC_947 3447-0010 211 µM 0.442897550692144 0.291505235676277 no 984 0.328919919554775 367 748350 SGTC_1565 sinapyl alcohol 95.1 µM 0.442250282244771 0.291762611161595 no 985 0.32915405194753 376 5280507 A phenol propionate derived from cinnamic acid. SGTC_336 4111-0029 111 µM 0.44195530625381 0.291879938549962 no 986 0.329260774018754 378 3131175 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.441520876861537 0.292052773858895 no 987 0.329417975549544 354 2374 Ca(2+)-ATPase inhibitor. SGTC_269 exalamide 29 µM 0.441477859493222 0.292069890670739 no 988 0.329433543347841 350 3316 A derivative of salicylamide. SGTC_2773 thioridazine 9.09 µM 0.441236433724048 0.292165963775645 no 989 0.329520919767756 359 5452 An antipsychotic. SGTC_590 k048-0076 22.4 µM 0.441062095097191 0.292235349327958 no 990 0.329584021906806 367 6832814 SGTC_3240 9133527 49.47 µM 0.440561306691238 0.29243470222928 no 991 0.329765310037712 378 17617455 SGTC_2845 9003024 42.97 µM 0.438678844941962 0.293184633919684 no 992 0.330447128939381 338 2990173 SGTC_72 0744-0168 198.391 µM 0.438519050490408 0.293248333580416 no 993 0.330505031711377 398 677577 SGTC_1081 sertraline 6 µM 0.438396959657635 0.29329700758229 no 994 0.330549275016078 372 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1200 1643-0193 18.4 µM 0.437502586084577 0.293653681986751 no 995 0.330873450502176 382 5403974 SGTC_3132 9126706 49.47 µM 0.436754964120784 0.293951986117485 no 996 0.33114453162415 384 850858 SGTC_3328 9140624 29.0385 µM 0.436442861084906 0.294076557911834 no 997 0.331257723629002 355 4904392 SGTC_1151 3909-8316 15.3 µM 0.435351096187478 0.294512513263701 no 998 0.331653800842689 370 800431 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.43529185720918 0.294536176655591 no 999 0.331675297314397 352 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2476 5806916 10.51 µM 0.434319609522923 0.294924672564993 no 1000 0.332028182946204 368 2870194 SGTC_111 0083-0039 52.457 µM 0.433653539065218 0.295190960772444 no 1001 0.332270024974109 388 759313 SGTC_2411 st077133 39.94 µM 0.43233819208749 0.295717148007939 no 1002 0.332747816485935 398 1403142 YNL221C POP1 SGTC_1111 tnp00062 510.699 nM 0.431877918692567 0.295901376062777 no 1003 0.332915072126464 344 676306 SGTC_3026 9090633 49.47 µM 0.430091125675206 0.296617052988433 no 1004 0.33356467759743 348 25236842 SGTC_2488 5268135 45.7 µM 0.430085951045538 0.296619126770644 no 1005 0.333566559608958 379 1270356 YLR208W SEC13 SGTC_492 tmb-8 126 µM 0.428508950381768 0.297251433991086 no 1006 0.334140309309558 377 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2263 7948595 193.29 µM 0.427271748137642 0.297747927917347 no 1007 0.334590703957513 381 2971371 SGTC_3136 9095672 49.47 µM 0.424639146377436 0.298805657826333 no 1008 0.335549875665164 341 17217380 SGTC_3260 9137109 49.47 µM 0.424295556745048 0.298943831565591 no 1009 0.335675139627896 364 17478346 SGTC_671 0560-0003 407 µM 0.424063793206661 0.299037051099133 no 1010 0.335759644981401 389 3238678 SGTC_979 1426-2828 121 µM 0.422150878584631 0.299806963861692 no 1011 0.336457446545913 366 747872 SGTC_858 0438-0351 2.77 µM 0.420701376838454 0.30039095854443 no 1012 0.336986577820545 350 2799119 SGTC_1602 st001878 87.6 µM 0.420503128056048 0.300470871609595 no 1013 0.33705897237319 391 595405 YLR310C CDC25 SGTC_1498 4478-3555 97.6 µM 0.420323326154244 0.300543357134767 no 1014 0.337124635893459 361 3437919 SGTC_2084 5306078 60.6385 µM 0.418336788190403 0.30134473709825 no 1015 0.337850447995597 398 679340 SGTC_1769 st044406 64.4 µM 0.417197075755935 0.301804937027832 no 1016 0.338267131968817 384 670903 SGTC_512 prima-1 270 µM 0.41524448981821 0.302594097144012 no 1017 0.338981466483363 349 322968 A re-activator of the apoptotic function of mutant p53. SGTC_62 0180-0423 3.232 µM 0.414429517703076 0.302923750838912 no 1018 0.339279787597967 377 30102 YGL099W LSG1 SGTC_900 1112-0045 141 µM 0.414225503425187 0.303006299132965 no 1019 0.339354482945143 356 56211 YIL048W NEO1 SGTC_3301 9125354 19.7965 µM 0.413319843684156 0.303372868799275 no 1020 0.339686146544245 350 41905162 SGTC_182 3448-4371 550.524 µM 0.413185778382412 0.303427149140028 no 1021 0.33973525344309 338 3491403 SGTC_1157 4092-0394 27.6 µM 0.411985267362273 0.303913405134627 no 1022 0.34017511085272 348 3659885 SGTC_1775 st081588 35.1725 µM 0.41174512171241 0.304010715626286 no 1023 0.340263124387702 367 1426443 YGL099W LSG1 SGTC_680 0417-1641 114 µM 0.411357915636075 0.304167646376347 no 1024 0.340405053991055 362 2835990 SGTC_1934 st074720 32.6 µM 0.410825838614982 0.304383350722814 no 1025 0.340600122621301 362 17250992 SGTC_2295 7971645 200 µM 0.410083361266902 0.304684465244939 no 1026 0.340872398910799 392 2978226 YKL099C UTP11 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.408314316001701 0.305402441478747 no 1027 0.341521465163197 392 65057 A dermal irritant. YDR527W RBA50 SGTC_2967 9089538 49.85 µM 0.408286976144713 0.305413543387433 no 1028 0.34153149989603 369 728216 SGTC_832 4083-0019 164 µM 0.406017712075837 0.306335647618255 no 1029 0.342364793154604 352 1990758 SGTC_2858 9025781 8.96 µM 0.405932182368585 0.306370426239193 no 1030 0.342396215441236 368 4894980 YPL153C RAD53 SGTC_1256 0570-0116 285 µM 0.403715815588538 0.307272266643626 no 1031 0.343210854065599 365 410638 SGTC_2430 5571206 200 µM 0.402893703515118 0.307607081280427 no 1032 0.343513211781694 374 1731771 SGTC_399 oxolinic acid 75 µM 0.402080898996745 0.307938262931948 no 1033 0.343812244820726 366 4628 A DNA gyrase inhibitor. SGTC_2426 5582046 32.21 µM 0.402016297052283 0.307964592064754 no 1034 0.343836016250726 357 2251934 SGTC_920 mycophenolic acid 780.421 nM 0.401999932198666 0.307971261872388 no 1035 0.343842038086555 351 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.401349296403106 0.308236492254839 no 1036 0.34408148703517 375 279621 SGTC_862 0452-0056 10.2 µM 0.400925301131574 0.308409386988812 no 1037 0.344237560714227 361 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_940 3232-1287 54.8 µM 0.400143279664375 0.30872838737312 no 1038 0.344525494279774 394 1585493 YIL048W NEO1 SGTC_803 4488-1585 147 µM 0.396180688945351 0.310347013561136 no 1039 0.345985868132891 399 747204 SGTC_79 0052-0007 94.094 µM 0.395842407963421 0.310485364404479 no 1040 0.346110644833809 391 2801472 SGTC_3316 9136639 10.545 µM 0.395547091164666 0.310606165592063 no 1041 0.346219587633448 388 4903665 SGTC_1261 0712-0010 12.7 µM 0.395030833693876 0.310817393003454 no 1042 0.346410066336049 385 2840123 SGTC_1998 st075797 76.8 µM 0.394978663830481 0.310838741840888 no 1043 0.346429317125869 395 24208315 SGTC_3165 9101544 49.47 µM 0.394620026699859 0.310985519775518 no 1044 0.346561665719153 384 5002184 SGTC_1021 4476-0760 85.3 µM 0.394441418841934 0.311058629093919 no 1045 0.346627584730313 365 746768 SGTC_115 0527-0192 112.043 µM 0.394257595423461 0.311133881077209 no 1046 0.346695433504074 407 4233931 SGTC_1574 spiramycin 23.7 µM 0.393951336457074 0.311259272162173 no 1047 0.346808483858957 371 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1921 5740136 50 µM 0.393747373819565 0.311342792388661 no 1048 0.346883780809433 400 1774243 SGTC_1867 st057372 64 µM 0.391500013824393 0.312263701321909 no 1049 0.347713839223859 369 688837 SGTC_3254 9136651 49.47 µM 0.391360732341204 0.312320813900059 no 1050 0.347765306672469 392 16454030 SGTC_700 3453-2283 142 µM 0.391296382322063 0.312347202243667 no 1051 0.347789086310706 364 565664 SGTC_2710 st078562 53.7235 µM 0.390670566486335 0.312603883943578 no 1052 0.348020378904782 392 17250908 SGTC_1444 4112-3581 28 µM 0.390227985745838 0.312785465689614 no 1053 0.348183984570234 370 2877249 SGTC_673 1082-0474 110 µM 0.389064854401259 0.313262891019731 no 1054 0.348614085686348 372 3098046 SGTC_1836 st055642 81 µM 0.388706481625049 0.313410053837059 no 1055 0.348746643535808 409 8571 SGTC_713 1488-1073 324 µM 0.387448538182994 0.313926852970178 no 1056 0.349212088011885 404 3312542 SGTC_2013 4024628 200 µM 0.387313109310134 0.313982512815842 no 1057 0.349262210816868 388 5230760 SGTC_3011 9081274 71.4286 µM 0.387019364439411 0.314103253419456 no 1058 0.349370936084517 365 6625322 SGTC_3188 9110789 49.47 µM 0.386593588654394 0.314278299205443 no 1059 0.349528552560766 386 849217 SGTC_830 4076-0286 57.8 µM 0.38604220305755 0.314505048024996 no 1060 0.349732706655465 370 6866659 SGTC_1335 1486-0900 202 µM 0.385927354271815 0.314552286626285 no 1061 0.349775235634283 374 X1335 SGTC_2951 9072950 58.06 µM 0.385462095961422 0.314743683673212 no 1062 0.349947541985837 390 16488155 SGTC_1139 k015-0024 46.9 µM 0.385320726409059 0.314801849864183 no 1063 0.349999903695711 378 2766652 SGTC_637 1181-0519 7.26 µM 0.384044583177106 0.315327123992693 no 1064 0.350472701936327 396 6252091 YGR060W ERG25 SGTC_1634 st006576 41 µM 0.383828888677923 0.315415943070892 no 1065 0.350552637496116 410 3915356 SGTC_2739 tacrine 100.86 µM 0.380305400114009 0.316868358972044 no 1066 0.351859363717548 388 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1484 3473-2379 286 µM 0.379709748806964 0.317114172120002 no 1067 0.352080441371773 387 671917 SGTC_1051 3253-3903 78 µM 0.3790999518227 0.317365906523156 no 1068 0.35230682103655 392 5509239 SGTC_1170 0310-0127 64.8 µM 0.377308428360936 0.318105965874912 no 1069 0.352972204679037 415 774975 SGTC_255 tunicamycin 200.472 nM 0.375100894837588 0.319018874044073 no 1070 0.353792715777791 360 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2220 6782180 200 µM 0.374194014749744 0.31939422595841 no 1071 0.354129988313077 396 833803 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.373001897820692 0.319887917224803 no 1072 0.354573515737873 391 756377 SGTC_3039 9090270 49.47 µM 0.372542786796254 0.320078134013294 no 1073 0.354744380762262 378 17173750 SGTC_3048 9093155 49.47 µM 0.371556593662781 0.320486888950621 no 1074 0.355111506044037 383 25236002 SGTC_2075 5212009 200 µM 0.370922885779059 0.320749661655799 no 1075 0.355347484397269 421 780898 SGTC_542 3381-0244 89.3 µM 0.370231746443886 0.321036351254558 no 1076 0.355604912153459 429 1112843 SGTC_1219 1469-0211 33.1 µM 0.369540965053759 0.321322999015004 no 1077 0.355862272414662 431 6822282 SGTC_1567 st069303 68.4 µM 0.367496259203629 0.322172096887285 no 1078 0.356624440832518 410 5581319 SGTC_1210 3013-0140 750 nM 0.367320300208077 0.322245210236154 no 1079 0.356690056731673 401 905973 SGTC_1668 st014914 51.6 µM 0.365771202423711 0.322889177924591 no 1080 0.357267905074838 390 2839556 SGTC_347 4534-1311 26.2 µM 0.365114960970818 0.323162141126788 no 1081 0.357512796737107 376 2862016 SGTC_2213 7173844 200 µM 0.363634650310377 0.323778224949176 no 1082 0.358065424216414 391 892728 SGTC_897 1000-0139 31.4 µM 0.363627143388288 0.323781350453966 no 1083 0.358068227449129 415 6151020 SGTC_2943 9068529 45.32 µM 0.362157928869421 0.324393296472888 no 1084 0.358617008248024 405 3270634 SGTC_3060 1327-0027 12.5 µM 0.36086869113572 0.324930670943503 no 1085 0.359098804778282 374 16000455 YPR107C YTH1 SGTC_291 SEC14.278 35.5 µM 0.360458613607209 0.325101674131452 no 1086 0.359252100451528 386 1068044 SGTC_1756 st041558 35.5 µM 0.360451900504478 0.325104473815967 no 1087 0.359254610140221 396 3955792 SGTC_723 4182-0001 115 µM 0.358687059526147 0.325840838929094 no 1088 0.359914605045927 399 744821 YLR208W SEC13 SGTC_1909 st060837 51.5 µM 0.358148011072051 0.326065888064331 no 1089 0.360116275581651 399 678937 SGTC_1428 4049-0204 61.7 µM 0.357208549598719 0.326458258384581 no 1090 0.360467842955805 396 X1428 SGTC_50 0929-0078 56.389 µM 0.355840867846877 0.327029820149422 no 1091 0.360979870744506 393 1377751 SGTC_14 0354-0009 295 µM 0.355215800434578 0.327291174526554 no 1092 0.361213964279569 408 1713507 SGTC_2952 9073731 13.78 µM 0.354979235360849 0.327390109664362 no 1093 0.361302573654549 353 16457353 SGTC_193 1273-0060 1.558 µM 0.354921094017482 0.327414427121312 no 1094 0.361324352599117 387 2847393 YHR072W ERG7 SGTC_2302 7771753 200 µM 0.354185748458332 0.327722046552735 no 1095 0.361599841659636 368 2203047 SGTC_2834 9001755 58.44 µM 0.352950872161596 0.3282388993036 no 1096 0.362062635745235 411 2989575 SGTC_964 1287-0107 19.4 µM 0.352300845467931 0.328511097718537 no 1097 0.362306327074986 395 51516812 YPR165W RHO1 SGTC_224 benfluorex 43.875 µM 0.352288251514384 0.328516372330899 no 1098 0.362311049028358 418 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2100 5377183 190 µM 0.352262244741017 0.328527264622168 no 1099 0.362320800025587 380 2844202 SGTC_1389 3405-0187 19 µM 0.351601736209262 0.328803951044654 no 1100 0.362568481471672 388 799890 SGTC_1140 3229-1848 2.98 µM 0.351286894730801 0.328935870894663 no 1101 0.362686562867157 409 2849525 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.349726449255185 0.329590018150108 no 1102 0.363272001013508 367 4000243 SGTC_2567 aureobasidin a 60 nM 0.349589259558615 0.329647553798838 no 1103 0.363323486284835 398 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_350 k064-0020 19.8 µM 0.349010964499668 0.32989012784534 no 1104 0.363540539030472 381 2790705 SGTC_690 glyoxal 20.3 µM 0.348668988366822 0.33003360824905 no 1105 0.363668914297148 386 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2789 5281112 71.43 µM 0.348451635623346 0.330124814334602 no 1106 0.363750514838753 382 765948 SGTC_594 1487-1584 10.8 µM 0.348197720899382 0.330231375433662 no 1107 0.363845849638301 390 5013332 SGTC_1019 4262-0212 3.4 µM 0.348097968800947 0.330273242442745 no 1108 0.363883304858747 388 4677213 SGTC_679 0422-0091 41.4 µM 0.345564036136038 0.331337472100258 no 1109 0.364835188828818 412 627384 YHR062C RPP1 SGTC_404 fumagillin 50 µM 0.344617899254155 0.331735191429427 no 1110 0.36519082378471 382 12015870 A methionine aminopeptidase binder. SGTC_2 0422-0095 29 µM 0.34428568178364 0.331874887827636 no 1111 0.365315725572512 363 6790840 SGTC_1359 1582-0056 520 nM 0.344234234031386 0.33189652353606 no 1112 0.365335069349803 405 3661189 SGTC_348 k064-0012 10.7 µM 0.342534629692723 0.332611585656908 no 1113 0.36597429382725 388 5066323 SGTC_2068 5226020 147 µM 0.341646951284808 0.33298529456843 no 1114 0.366308299476744 390 1810509 SGTC_360 0957-0399 1.01 µM 0.341479447627011 0.33305583153225 no 1115 0.366371337238815 384 6752301 YPR165W RHO1 SGTC_636 0kpi-0074 126 µM 0.340350100636611 0.3335315615238 no 1116 0.366796445912184 389 616434 SGTC_971 1315-0384 26.7 µM 0.338924107070965 0.334132634476536 no 1117 0.367333451660784 411 6769120 SGTC_2181 6316240 54.2555 µM 0.338197267542499 0.334439169708515 no 1118 0.367607267428556 390 12779990 SGTC_1101 ebselen 5.29 µM 0.33764749595195 0.334671102170346 no 1119 0.367814422694611 419 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2888 9058547 12.99 µM 0.33609510040135 0.335326352568483 no 1120 0.368399576527787 385 16476514 SGTC_142 0335-0849 62.6745 µM 0.335869202486648 0.335421743611879 no 1121 0.368484751075567 371 3889043 YPR107C YTH1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.335368268059451 0.335633313546812 no 1122 0.368673650872302 384 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_934 2950-0684 338 µM 0.334669829934958 0.335928386260748 no 1123 0.368937081262307 427 1121253 SGTC_1514 1189-1591 158 µM 0.334209138178053 0.336123072435054 no 1124 0.369110874404485 427 767698 YMR146C TIF34 SGTC_578 3460-0051 92 µM 0.334043236245116 0.336193192583308 no 1125 0.369173466447375 439 2876744 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.332969701700748 0.336647070613379 no 1126 0.369578576975041 386 688664 SGTC_3342 9147791 14.508 µM 0.331858813588842 0.337116991949393 no 1127 0.369997935774563 404 1838168 SGTC_202 3594-0513 34.79 µM 0.331189586279963 0.337400207322558 no 1128 0.370250642866624 389 708429 SGTC_2396 5342950 42.78 µM 0.329160974757227 0.338259273245879 no 1129 0.371017009213587 420 1886677 SGTC_972 1319-0219 195 µM 0.328627862322448 0.338485172952065 no 1130 0.371218492823144 418 23903702 SGTC_2813 7971799 71.43 µM 0.328581703642167 0.338504734849471 no 1131 0.37123593961784 401 2234054 SGTC_2487 5918373 44.05 µM 0.325760098170085 0.339701347735333 no 1132 0.372302935177368 443 2876279 SGTC_3281 9140613 49.47 µM 0.325368239204484 0.339867659134972 no 1133 0.372451195170148 364 16013766 SGTC_3202 9113761 49.47 µM 0.325362408859695 0.339870133864769 no 1134 0.372453401226155 428 4798415 SGTC_669 0108-0021 26.2 µM 0.32535235799895 0.339874400037687 no 1135 0.372457204229203 421 17201 SGTC_927 2425-1185 123 µM 0.324500365758429 0.340236109856915 no 1136 0.372779622696226 426 730375 SGTC_1037 k284-1091 78.7 µM 0.323429293980836 0.340691037617728 no 1137 0.373185073646827 397 3334711 SGTC_774 k060-0086 136 µM 0.32198281119994 0.341305785575496 no 1138 0.37373285817391 422 5911235 SGTC_326 k292-0812 17.5 µM 0.320515999313757 0.341929603633482 no 1139 0.374288601940103 424 3579357 SGTC_466 geldanamycin 89.2 µM 0.31962787981434 0.342307520528108 no 1140 0.374625218581226 406 5288382 HSP90 inhibitor. SGTC_1784 st039334 36.3 µM 0.319203693980711 0.34248807789789 no 1141 0.374786027992632 407 3496984 SGTC_3272 9137413 49.47 µM 0.318576886860792 0.34275494818834 no 1142 0.375023691256234 404 17614870 SGTC_659 k018-0002 107 µM 0.318482533304259 0.34279512709276 no 1143 0.375059470925861 404 6797879 YHR007C ERG11 SGTC_822 1487-0950 154 µM 0.317757292497573 0.343104018251537 no 1144 0.375334524269153 416 1958375 SGTC_1242 0402-0103 60.1 µM 0.317163235445954 0.343357114386464 no 1145 0.375559872366324 389 432868 SGTC_844 0330-0132 15.3 µM 0.31674763462949 0.34353422158566 no 1146 0.375717550576248 432 2828079 SGTC_2275 7947463 200 µM 0.315835422391356 0.343923078858937 no 1147 0.376063715025964 403 1225414 SGTC_2719 novobiocin 32.65 µM 0.315734726764909 0.343966013457165 no 1148 0.376101932915827 417 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3094 9117742 49.47 µM 0.314747204878663 0.344387179551734 no 1149 0.376476800050913 427 17149698 SGTC_1958 st076513 41.9 µM 0.314665563518203 0.344422007246461 no 1150 0.376507796647606 418 732122 YGL099W LSG1 SGTC_937 3122-0005 46.7 µM 0.314368021219199 0.344548948096414 no 1151 0.376620770619339 428 759535 SGTC_2965 9082772 38.63 µM 0.313529963741476 0.344906583692507 no 1152 0.376939029818595 371 16459634 SGTC_1178 0988-0033 191 µM 0.313119950990878 0.345081604492099 no 1153 0.377094766003652 399 5392207 SGTC_3183 9108214 49.47 µM 0.312294167974964 0.345434204353715 no 1154 0.377408485930462 410 4974831 SGTC_1992 st073643 23.3 µM 0.310327773410082 0.346274371925148 no 1155 0.378155856422813 388 3161292 SGTC_2477 5967686 25.23 µM 0.308642369461882 0.346995085362645 no 1156 0.378796793572035 408 776118 SGTC_93 0109-0045 59.227 µM 0.308586559108755 0.34701896050677 no 1157 0.378818023235314 412 88733 SGTC_780 0109-0199 192 µM 0.308188499422308 0.347189264304416 no 1158 0.378969451496111 433 610414 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.30788946835554 0.347317220512592 no 1159 0.379083219910089 383 688664 SGTC_529 4076-0302 30.3 µM 0.307865396852416 0.347327521531436 no 1160 0.379092378533712 409 5816522 SGTC_2337 9009472 200 µM 0.307836653235583 0.347339822055138 no 1161 0.379103314872294 427 5742383 SGTC_2109 5483026 200 µM 0.307752781029915 0.347375715188432 no 1162 0.379135227026662 436 759335 SGTC_1893 st059353 36.1 µM 0.305964550446434 0.348141314179094 no 1163 0.379815818432619 432 3112488 SGTC_103 0844-0104 51.839 µM 0.305733181522128 0.348240415966815 no 1164 0.379903903516692 393 5375804 SGTC_887 0885-0007 9.62 µM 0.305184688397556 0.348475392320201 no 1165 0.380112746693399 430 5719458 SGTC_3064 1327-0027 10 µM 0.304163694701749 0.348912944384034 no 1166 0.380501591336783 431 16000455 YPR107C YTH1 SGTC_2257 7960413 200 µM 0.304121133575071 0.348931188540031 no 1167 0.380517803333075 414 2974689 YIL048W NEO1 SGTC_1619 st003326 88.7 µM 0.302598716471723 0.349584013792832 no 1168 0.381097846372932 401 2849032 SGTC_2045 5106652 78.05 µM 0.301908423632333 0.349880163944155 no 1169 0.381360937049589 438 673349 SGTC_825 1988-2224 89.6 µM 0.301592416574943 0.350015768112949 no 1170 0.381481394833656 401 1180859 SGTC_1092 toremifene 6.32 µM 0.300992034106031 0.350273455441296 no 1171 0.381710284447319 434 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1750 st081859 2.357 µM 0.300517882409353 0.350477012585188 no 1172 0.381891079121669 419 5291695 SGTC_2241 6772625 37.8075 µM 0.300441946268308 0.350509616573678 no 1173 0.381920036067919 434 2285411 SGTC_486 niguldipine 82 µM 0.300384524595408 0.350534271909981 no 1174 0.381941933277655 416 1236 A calcium channel blocker. SGTC_1924 st058459 75.1 µM 0.299597827328946 0.350872122122646 no 1175 0.382241970816749 424 688683 SGTC_2185 6113692 200 µM 0.298725100781315 0.351247055938975 no 1176 0.382574901703428 403 874150 SGTC_1832 st054113 55 µM 0.29686922500058 0.352044843538277 no 1177 0.383283176212709 427 1251267 SGTC_257 daunorubicin 18.5 µM 0.296345950760162 0.352269902010104 no 1178 0.383482948691452 424 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_731 3966-0296 387 µM 0.29582355780653 0.352494633058329 no 1179 0.383682415620814 407 660956 SGTC_159 3970-0959 50 µM 0.29431083897454 0.353145687990406 no 1180 0.38426019547194 411 6615653 SGTC_1561 5-methoxyflavone 52.9 µM 0.293880040083917 0.353331177115691 no 1181 0.384424785345703 441 94525 SGTC_1699 st031318 29.054 µM 0.293279731678208 0.35358971007204 no 1182 0.384654172317611 436 5340658 SGTC_3068 9116768 49.47 µM 0.290996629422242 0.354573582746056 no 1183 0.3855269486747 437 41904888 SGTC_1058 3448-5425 97.3 µM 0.290805454871941 0.354656011035608 no 1184 0.385600056590186 437 7279705 SGTC_1454 4239-0054 42.6 µM 0.290773368995764 0.354669846095894 no 1185 0.385612327092111 447 1340767 SGTC_854 0422-0053 192 µM 0.289370366918231 0.355274991667862 no 1186 0.386148984602764 412 3596728 SGTC_1632 st005650 90 µM 0.287065867725102 0.356269764583792 no 1187 0.387030943174738 399 2759605 SGTC_2787 5284540 71.43 µM 0.286756551166195 0.356403360548763 no 1188 0.387149366730939 425 736958 SGTC_445 e6 berbamine 66 µM 0.285756987277359 0.356835199541331 no 1189 0.387532127064475 426 6610268 A calcium/calmodulin antagonist. SGTC_2880 9042983 58.44 µM 0.28554674098518 0.356926055081323 no 1190 0.387612650046507 423 6464714 SGTC_3337 9144342 33.5465 µM 0.285247606499408 0.357055336628149 no 1191 0.387727224968257 391 17682949 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.284879253330722 0.357214556027563 no 1192 0.387868325560692 434 279621 SGTC_80 0159-0065 512.242 µM 0.284586740118386 0.357341011579507 no 1193 0.387980385607499 425 1548079 SGTC_1862 st057513 3.81 µM 0.284163480747029 0.357524017365134 no 1194 0.388142550232087 411 5393163 SGTC_2378 9074213 121.43 µM 0.282417982799878 0.358279068753106 no 1195 0.388811513853536 435 657714 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.281426475036526 0.358708213184586 no 1196 0.389191657095925 428 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.280727211473661 0.359010975805227 no 1197 0.389459817970939 437 688798 SGTC_283 0987-0079 11.7 µM 0.280239096860615 0.359222369028781 no 1198 0.389647036455006 437 411556 SGTC_1649 st011737 51.3 µM 0.279075968024815 0.359726271800472 no 1199 0.390093262732649 428 1761035 SGTC_549 1661-1316 519 µM 0.278657089439657 0.359907802530495 no 1200 0.390253998094062 433 2857282 SGTC_882 0843-0131 351 µM 0.27853014884107 0.359962821418734 no 1201 0.390302712437504 422 5425421 SGTC_315 k915-0449 187 µM 0.278103319719197 0.360147839959004 no 1202 0.390466523729651 434 20970215 YNL149C PGA2 SGTC_1309 pyrazolanthrone 13.4 µM 0.277967360856954 0.360206781222586 no 1203 0.390518707002359 444 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2870 9038528 12.99 µM 0.276794326600152 0.360715456176735 no 1204 0.390969018878275 424 6463316 SGTC_2355 9061122 103.12 µM 0.276547057385491 0.360822713569616 no 1205 0.39106396084321 427 5302957 SGTC_1871 st057448 67.3 µM 0.276542306984705 0.360824774247135 no 1206 0.391065784879846 452 691747 SGTC_581 0958-0271 211 µM 0.276296103220224 0.360931580568415 no 1207 0.391160324327223 400 4591145 SGTC_2050 5263056 171 µM 0.275725215252422 0.36117928074071 no 1208 0.391379563555274 415 763468 YGL055W OLE1 SGTC_1407 3909-7909 12.3 µM 0.273826279874247 0.362003620171075 no 1209 0.392109063398461 424 4411780 SGTC_1702 st027038 51 µM 0.272797479510869 0.362450496475732 no 1210 0.39250444858316 408 5521182 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.271478079849879 0.363023873681736 no 1211 0.393011678316497 404 6312947 SGTC_2605 digitonin 300 nM 0.270561048484724 0.363422572985238 no 1212 0.393364328755321 423 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2246 7293507 91.5585 µM 0.270287338392008 0.363541603090876 no 1213 0.393469602740278 445 887656 SGTC_2678 equilin 100 µM 0.270201523630021 0.363578924633305 no 1214 0.393502610295556 407 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1508 1080-0625 72.9 µM 0.26966860891972 0.363810722575556 no 1215 0.393707606277564 419 767111 SGTC_114 0364-0001 490.298 µM 0.266455896808855 0.36520918545147 no 1216 0.394944060588152 388 4003655 SGTC_1070 indatraline 8.81 µM 0.26585476400637 0.365471052656597 no 1217 0.395175532376652 447 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2183 6420625 130.508 µM 0.265795728743813 0.365496773152159 no 1218 0.395198266451002 404 2897619 SGTC_1215 3852-0577 11.2 µM 0.263525829404901 0.366486181086827 no 1219 0.396072658958909 389 2884876 SGTC_460 trequinsin 123 µM 0.262254402058305 0.367040761643469 no 1220 0.396562656925329 433 5537 A vasodilator. SGTC_1708 st033234 31.827 µM 0.261497013702923 0.367371256879095 no 1221 0.396854626074228 401 674664 SGTC_2677 mitomycin C 100 µM 0.26039585869928 0.367851933946939 no 1222 0.397279218542057 429 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3061 glucosamine 200 µM 0.259991694116668 0.368028412174572 no 1223 0.397435090242766 457 91431 and experimental redox chemotherapeutic SGTC_1883 5-benzylidenerhodanine 20 µM 0.259612287368193 0.368194105259418 no 1224 0.397581428645784 437 1273210 SGTC_683 panaxydol 45 µM 0.257208396095837 0.369244492283685 no 1225 0.398508951427396 420 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2445 5742597 35.57 µM 0.256775456134431 0.369433770660516 no 1226 0.398676059057354 411 1774255 SGTC_2670 beta-carotene 100 µM 0.256501953558177 0.369553360424282 no 1227 0.398781636083573 413 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_60 0986-0278 202 µM 0.25632112129961 0.369632436765067 no 1228 0.398851444730291 445 3110598 SGTC_2584 androsterone 48.74 µM 0.255296041287963 0.370080799286498 no 1229 0.399247228631947 418 2754130 A steroid. SGTC_938 3126-1755 342 µM 0.255074027299296 0.370177929875748 no 1230 0.39933296200405 453 1777771 SGTC_1408 3909-7976 48.8 µM 0.252680407680142 0.371225657392929 no 1231 0.400257594546266 427 24152374 SGTC_1310 1188-0297 994 nM 0.25204339241861 0.371504650906547 no 1232 0.400503761948257 429 1588352 SGTC_2596 sinensetin 100 µM 0.251113145733709 0.371912192215418 no 1233 0.40086331632555 415 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1690 st023502 41.2 µM 0.249620833932454 0.372566274102786 no 1234 0.401440292691836 461 24207482 SGTC_3270 9137563 49.47 µM 0.247863216059383 0.373337111384389 no 1235 0.402120120633087 463 17015724 SGTC_1822 st052468 42 µM 0.247440643519931 0.373522514479185 no 1236 0.402283611453373 436 2873678 SGTC_2184 6075246 200 µM 0.245944216206335 0.37417930497246 no 1237 0.402862707621273 447 2267320 SGTC_1959 st077091 55.8 µM 0.244714584473658 0.374719270931248 no 1238 0.4033387172819 432 821356 YKL052C ASK1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.243965108991959 0.3750485073449 no 1239 0.403628921265827 418 6708739 YPR165W RHO1 SGTC_2074 5212007 75.395 µM 0.243459495602651 0.375270669255151 no 1240 0.403824729530334 465 758611 SGTC_2421 5690543 90.72 µM 0.24310032355283 0.375428511318761 no 1241 0.403963840286895 458 3397993 SGTC_1899 st063254 59.6 µM 0.243083566113096 0.375435876067331 no 1242 0.403970330899658 436 3093813 SGTC_1230 0170-0365 3.77 µM 0.242531208960878 0.375678657611869 no 1243 0.404184288655527 437 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2659 sanguinarine 24.21 µM 0.241919292249496 0.375947675280803 no 1244 0.404421350510097 447 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_610 4215-0184 155 µM 0.241819933153884 0.375991362331628 no 1245 0.404459846401841 446 5605015 SGTC_63 0099-0242 26.702 µM 0.241220322801562 0.376255037820858 no 1246 0.404692180287186 433 3898502 YLR359W ADE13 SGTC_229 benomyl 22.8748 µM 0.239165452030261 0.377159093905595 no 1247 0.405488645321617 427 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_986 1493-0483 84 µM 0.238829070960092 0.377307151629265 no 1248 0.405619063529608 452 40079 SGTC_2725 haloperidol 53.21 µM 0.238408065517667 0.377492482079836 no 1249 0.405782306190395 456 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1149 3909-7961 23.3 µM 0.238390695565751 0.377500129098014 no 1250 0.405789041650657 422 735261 SGTC_1597 7-benzyloxygramine 47.5 µM 0.238208919331502 0.377580157886049 no 1251 0.405859529793911 451 260807 SGTC_3226 9131256 49.47 µM 0.236237859276895 0.378448273423974 no 1252 0.406624051656046 420 17178073 SGTC_536 3852-0578 10.6 µM 0.235631489720631 0.378715460917534 no 1253 0.406859318057675 418 2869208 SGTC_702 1488-0190 94 µM 0.235198608979736 0.378906238689254 no 1254 0.407027292796098 442 949357 SGTC_3108 9121785 49.47 µM 0.234364044838106 0.37927412828436 no 1255 0.407351184724598 454 17140271 SGTC_37 0566-0070 1.56 µM 0.233503605179885 0.379653538727768 no 1256 0.407685185197716 463 1626686 SGTC_129 0088-0017 176.636 µM 0.233412525148521 0.379693707212472 no 1257 0.407720544047833 454 182446 SGTC_1087 pterostilbene 9.05 µM 0.232128425575689 0.380260164006516 no 1258 0.408219133683942 438 5281727 Similar to reservatol, lowers cholesterol. SGTC_3186 9110464 49.47 µM 0.231262900420386 0.380642119452736 no 1259 0.408555283329938 448 17018021 SGTC_2437 5741531 144.16 µM 0.228927078490332 0.381673495346231 no 1260 0.409462796893298 465 2262990 SGTC_3207 9114163 49.47 µM 0.227877547227619 0.382137187210306 no 1261 0.40987071912271 457 849233 SGTC_2690 usnic acid 100 µM 0.226590403495818 0.382706089099796 no 1262 0.410371127561546 451 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2923 7992654 58.14 µM 0.226254469714588 0.38285460946093 no 1263 0.410501754042918 454 2985126 SGTC_2955 9076254 12.21 µM 0.226149604921549 0.382900974974939 no 1264 0.410542532324298 455 16459619 SGTC_656 4090-1979 187 µM 0.22386364284663 0.383912119111864 no 1265 0.411431703284982 448 22330961 SGTC_2105 5350118 200 µM 0.223673173690185 0.383996404663075 no 1266 0.411505810699489 434 2133313 SGTC_3147 9097027 49.47 µM 0.223404054008802 0.384115503642284 no 1267 0.411610524707503 449 25236841 SGTC_2842 9000675 19.48 µM 0.223116006230316 0.384242991380549 no 1268 0.411722610581193 468 2989072 SGTC_697 0508-1955 564 µM 0.222064361589363 0.384708547472202 no 1269 0.412131890275085 443 6243113 SGTC_871 0574-0004 149 µM 0.221798707833367 0.384826176960814 no 1270 0.412235292704038 462 9551173 SGTC_392 N-ethylmaleimide 8.33 µM 0.221369559089885 0.385016223195672 no 1271 0.412402346397025 424 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_468 gf-109203x 121 µM 0.220673594791856 0.385324485986241 no 1272 0.412673296462035 452 2396 A protein kinase C inhibitor. SGTC_2249 haloperidol 116.36 µM 0.21958444073394 0.385807049317672 no 1273 0.413097405084629 462 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1063 disulfiram 1.84 µM 0.218119509178894 0.386456384241458 no 1274 0.413667998608164 425 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2736 butenafine 14.65 µM 0.215577642746328 0.387583827340303 no 1275 0.414658492266799 440 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_160 3453-0671 289.699 µM 0.215003667567501 0.387838545260921 no 1276 0.414882229561824 424 5322268 SGTC_624 k048-0052 28 µM 0.214365141102748 0.388121966379992 no 1277 0.415131161589204 432 6835531 SGTC_3340 9146634 11.102 µM 0.214256889135542 0.388170021817958 no 1278 0.41517336742077 468 4907387 SGTC_1286 0929-0070 131 µM 0.213574359533004 0.388473051179657 no 1279 0.415439498083356 427 1420408 SGTC_2831 7999036 19.48 µM 0.213388960097533 0.388555376518749 no 1280 0.415511795389142 473 2988270 SGTC_1761 st044296 37 µM 0.213042392287395 0.388709280984481 no 1281 0.415646948663426 429 1826700 SGTC_298 1391-0729 10 µM 0.212998283458385 0.388728870167494 no 1282 0.415664150782897 440 3237558 SGTC_1001 4048-4355 44.4 µM 0.212997686036679 0.388729135490539 no 1283 0.415664383774085 455 21824233 SGTC_2598 perillyl alcohol 100 µM 0.212813361623068 0.388810998928822 no 1284 0.415736270699703 435 10819 An apoptosis inducer. SGTC_3251 9135047 49.47 µM 0.212581840419499 0.388913830728522 no 1285 0.415826568472113 455 17682963 SGTC_716 1683-5115 658 µM 0.212281428602033 0.389047272387825 no 1286 0.415943741547874 471 723597 SGTC_1807 st050092 58.9 µM 0.210145988854351 0.389996202029022 no 1287 0.416776866426423 450 5008496 SGTC_2617 dihydrotanshinone i 20.83 µM 0.209459226916588 0.390301519479524 no 1288 0.417044880793797 437 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2747 doxorubicin 7.63 µM 0.208138080758829 0.390889058693796 no 1289 0.417560577027869 472 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3081 9117243 49.47 µM 0.207673819578374 0.391095583837745 no 1290 0.417741830472592 447 45595589 SGTC_2640 pentamidine 10.38 µM 0.20490014513999 0.39233008227895 no 1291 0.418825070909607 456 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_628 1636-0253 16 µM 0.204861039153794 0.392347495231015 no 1292 0.418840347918219 457 4456143 SGTC_430 0958-0115 16.4 µM 0.203521599270505 0.39294404539693 no 1293 0.419363682584001 434 6833180 SGTC_1032 k061-1018 98.7 µM 0.203350681235934 0.393020185774615 no 1294 0.419430472522348 436 4005393 SGTC_1399 3562-5772 25 µM 0.202557685573232 0.393373502113101 no 1295 0.419740383161006 442 23847490 SGTC_405 ebelactone b 50 µM 0.199912820658732 0.394552545504645 no 1296 0.420774381702526 450 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1494 4358-1428 177 µM 0.199763053636978 0.39461933854435 no 1297 0.420832948899642 464 1564571 SGTC_1234 0326-0494 15.5 µM 0.196361498573045 0.396137193381659 no 1298 0.422163614634864 467 1547813 SGTC_3179 9107801 49.47 µM 0.19605144434834 0.396275625671203 no 1299 0.422284950224392 403 4818259 SGTC_3213 9129884 49.47 µM 0.195962796730596 0.396315207258551 no 1300 0.422319642644777 421 17190742 SGTC_1491 4138-0063 26.5 µM 0.195909558104844 0.3963389790745 no 1301 0.422340477975845 467 23883227 SGTC_2189 6047310 154.431 µM 0.195679148519333 0.396441864727131 no 1302 0.422430652980825 484 711535 SGTC_3103 9120822 49.47 µM 0.194629684174464 0.396910577089382 no 1303 0.422841431408938 490 17141819 SGTC_1039 k821-0043 94 µM 0.194196608019356 0.397104041266232 no 1304 0.423010969362059 456 15992768 SGTC_2794 7785382 27.27 µM 0.193170770536424 0.397562405277104 no 1305 0.42341261465905 480 2205081 SGTC_958 1222-0007 33 µM 0.19299225356645 0.39764218457839 no 1306 0.423482517402519 462 7312461 SGTC_1496 4469-0713 57.4 µM 0.192516999756884 0.397854596547341 no 1307 0.423668626543658 463 746691 SGTC_1418 3966-3099 2.4 µM 0.191334680515035 0.398383158613832 no 1308 0.424131695924877 474 740335 SGTC_1755 st041960 45.185 µM 0.190782679620504 0.398629997449741 no 1309 0.424347929548007 471 2257073 SGTC_2379 9035213 200 µM 0.190425331968491 0.398789814617456 no 1310 0.424487924398711 477 646551 SGTC_1735 st034310 56.75 µM 0.190065196091787 0.398950895938062 no 1311 0.424629021205373 490 871153 SGTC_2456 5770359 74.46 µM 0.1889512703567 0.399449240687004 no 1312 0.425065504666533 480 3118787 SGTC_2683 piperine 63.03 µM 0.18714376000019 0.400258227616111 no 1313 0.425773959342494 489 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3014 9081533 49.47 µM 0.186942024942574 0.400348544745042 no 1314 0.425853044418453 472 21367265 SGTC_3255 9139072 49.47 µM 0.186661125685356 0.400474312696382 no 1315 0.425963168763752 452 17646060 SGTC_417 st075190 100 µM 0.186480562308057 0.400555162382819 no 1316 0.426033960265556 473 222757 SGTC_1008 4106-0037 6 µM 0.186053229884779 0.400746523205037 no 1317 0.426201509291452 489 2905394 SGTC_1799 st045822 46.1415 µM 0.185883308407723 0.400822621206235 no 1318 0.426268136018079 475 3674992 SGTC_1781 st038725 66.3 µM 0.184308971966946 0.401527854051451 no 1319 0.426885537944047 421 4270275 YIL048W NEO1 SGTC_2921 7974240 10.71 µM 0.182683759743458 0.402256213568104 no 1320 0.427523079580901 454 2979074 YDR527W RBA50 SGTC_2828 7998861 71.43 µM 0.18182857492047 0.402639612007763 no 1321 0.427858629385704 477 2988188 SGTC_2971 9092186 9.93 µM 0.180706913098095 0.403142619958447 no 1322 0.428298816128868 396 25236400 SGTC_2315 7733312 200 µM 0.180472321754675 0.403247842474293 no 1323 0.428390890828106 428 726316 SGTC_1296 1068-0102 11.9 µM 0.180260304573662 0.403342945706754 no 1324 0.428474108753613 475 767053 SGTC_2809 7964133 12.99 µM 0.179138700006138 0.403846151900941 no 1325 0.428914397630168 471 1253665 SGTC_853 0419-0306 21 µM 0.17873821603489 0.404025867038993 no 1326 0.429071630148513 475 762713 SGTC_2025 5147754 141 µM 0.176709209140816 0.404936684098853 no 1327 0.429868403434638 472 315777 YLR208W SEC13 SGTC_384 k007-0144 5.16 µM 0.176307936889629 0.405116875574714 no 1328 0.430026013485469 455 6824886 SGTC_3049 9092223 49.47 µM 0.175834447464127 0.405329522074265 no 1329 0.430212003038407 467 8623917 SGTC_2007 4011539 71.82 µM 0.173515422650579 0.406371410397325 no 1330 0.431123153113539 468 45595301 SGTC_1466 k213-0079 57.5 µM 0.172605333969998 0.406780475443367 no 1331 0.431480829465248 481 3657981 SGTC_284 0988-0104 32.6 µM 0.172124360808763 0.406996703524243 no 1332 0.431669880708728 470 4666532 SGTC_540 1187-0821 17.3 µM 0.171405230622499 0.407320051226586 no 1333 0.431952571101537 499 847520 SGTC_3137 9097352 49.47 µM 0.171014198579352 0.407495900315458 no 1334 0.432106300604823 482 44120435 SGTC_836 0330-0104 1.35 µM 0.170859786516515 0.407565345337819 no 1335 0.432167008666426 454 46494820 SGTC_12 0849-0099 9.267 µM 0.170636386179001 0.40766582217224 no 1336 0.432254842731274 483 6071388 SGTC_3016 9080866 49.47 µM 0.169708890996951 0.408083038531061 no 1337 0.432619540751186 487 17066299 SGTC_3298 9116858 71.43 µM 0.169146528529697 0.40833605756022 no 1338 0.432840693842175 472 2506942 SGTC_1150 3909-7983 10.9 µM 0.168926317101068 0.408435145860887 no 1339 0.432927299308298 472 23965914 SGTC_990 3985-0011 41.3 µM 0.168755010220087 0.408512232683579 no 1340 0.432994673663201 479 5399565 YGL099W LSG1 SGTC_2496 diffractaic acid 79.83 µM 0.168694439616424 0.408539489852133 no 1341 0.433018496321033 449 94870 An apoptosis inducer which activates caspases. SGTC_1571 st070080 73.4 µM 0.168119066457887 0.408798433589246 no 1342 0.433244804985139 462 4315245 SGTC_892 0929-0076 29 µM 0.16713107490358 0.409243166938991 no 1343 0.433633457821854 451 5751038 SGTC_1174 0739-0097 51.1 µM 0.167009304546448 0.409297988602733 no 1344 0.433681363890689 471 728447 SGTC_3146 9095609 49.47 µM 0.163861420905247 0.410715795277599 no 1345 0.434920119088537 465 17173999 SGTC_376 3970-0862 59.1 µM 0.162969564804527 0.411117700267992 no 1346 0.435271199019256 471 3135186 SGTC_808 0711-0032 135 µM 0.162732174789868 0.41122469316791 no 1347 0.435364656415907 489 4252555 SGTC_441 propafenone 146 µM 0.162550044355174 0.411306784768159 no 1348 0.435436361274256 489 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1448 4255-0083 152 µM 0.162546288797669 0.411308477550428 no 1349 0.435437839861782 472 5399660 SGTC_1803 st050068 52.4 µM 0.161812777552256 0.411639132472408 no 1350 0.435726645310361 476 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2370 9071495 200 µM 0.160647009437122 0.412164770798231 no 1351 0.436185713769504 478 21791103 SGTC_1747 st037496 66.6 µM 0.158664649540044 0.413058967204147 no 1352 0.436966545440469 443 723305 SGTC_585 0kpi-0023 191 µM 0.158452961475464 0.413154481510123 no 1353 0.437049941813133 481 64601 SGTC_2292 7671323 168.05 µM 0.158270244513373 0.413236928099216 no 1354 0.437121927014915 485 937504 SGTC_867 0518-0118 155 µM 0.157458864546358 0.413603089766001 no 1355 0.43744161238458 489 6848158 SGTC_121 0557-0495 61.343 µM 0.155050282545308 0.414690482359282 no 1356 0.438390838423916 492 3104427 SGTC_1136 pergolide 1.05886 µM 0.154744414164594 0.414828618472147 no 1357 0.438511407128113 499 47811 A dopamine receptor agonist. SGTC_27 0485-0001 32.618 µM 0.154078743551741 0.415129284654892 no 1358 0.438773824157576 490 2054479 SGTC_2743 auranofin 4.32 µM 0.153651613655171 0.415322234365628 no 1359 0.438942219153705 490 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2561 acetosyringone 100 µM 0.153425538484339 0.415424368800228 no 1360 0.439031353253572 493 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2823 7987624 58.44 µM 0.152944952122443 0.415641503245525 no 1361 0.439220843119164 474 2239440 SGTC_2517 totarol 10 µM 0.152056629507808 0.41604292538567 no 1362 0.439571135496949 453 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3052 9092717 49.47 µM 0.151786719625145 0.41616491173718 no 1363 0.439677578483217 471 25237534 SGTC_3166 9102297 49.47 µM 0.151573925732732 0.416261090088454 no 1364 0.439761500001907 468 25237072 SGTC_3193 9111931 49.47 µM 0.151453667042859 0.416315446697927 no 1365 0.439808928744199 467 17087244 SGTC_1732 st034308 51.822 µM 0.150836092872543 0.416594613780503 no 1366 0.440052506992475 424 830119 SGTC_1388 3346-4487 254 µM 0.150656109999078 0.416675980828355 no 1367 0.440123498550639 480 3345614 SGTC_2849 9019321 12.99 µM 0.150167920295913 0.416896700653215 no 1368 0.440316067378326 482 16489627 SGTC_2186 6124449 200 µM 0.150046968643079 0.416951389241742 no 1369 0.440363779536137 490 3834182 YLR033W RSC58 SGTC_988 1497-1057 103 µM 0.148970453575319 0.417438208875114 no 1370 0.440788473704458 489 3533044 SGTC_743 1275-0778 158 µM 0.146680740420714 0.418474078729486 no 1371 0.441692010539303 482 2849257 YMR203W TOM40 SGTC_1332 1480-0653 17.5 µM 0.146666437583114 0.418480551140959 no 1372 0.44169765549781 497 5749438 SGTC_327 1273-0057 3.96 µM 0.145730455647398 0.418904155569869 no 1373 0.44206708894748 498 3108138 SGTC_2211 7117706 200 µM 0.143316737975807 0.419996982842536 no 1374 0.44302001864789 495 822771 SGTC_708 3448-5400 146 µM 0.143105148277752 0.420092811076072 no 1375 0.44310356952815 496 3462195 SGTC_943 3253-1379 105 µM 0.142608087424582 0.420317946823059 no 1376 0.443299854964876 490 668464 SGTC_1729 st035615 45.989 µM 0.142219842336731 0.420493814352247 no 1377 0.443453179589285 492 17385451 SGTC_2123 5259487 200 µM 0.141298400633873 0.42091127312899 no 1378 0.443817106524357 488 2173474 SGTC_2917 7979103 53.79 µM 0.140098330119402 0.421455097862269 no 1379 0.444291149976686 491 2980565 SGTC_738 1315-0003 72.4 µM 0.139438051563363 0.421754374097054 no 1380 0.444552002623419 495 6251474 SGTC_3308 9128332 17.569 µM 0.139010906171581 0.421948005055345 no 1381 0.444720765424111 484 17332805 YDL196W YDL196W SGTC_1961 st076550 68.7 µM 0.138662703107785 0.422105864319598 no 1382 0.444858345959688 456 1579337 SGTC_1700 st030840 7.9285 µM 0.138455048814653 0.422200011190217 no 1383 0.444940396617006 473 5499307 SGTC_428 3448-4153 16.5 µM 0.136857887862328 0.422924284590646 no 1384 0.445571563081396 435 3834874 SGTC_216 k038-0035 28.382 µM 0.136678584861992 0.423005610427776 no 1385 0.445642428729509 470 4444231 YPR107C YTH1 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.136220873057858 0.423213228046731 no 1386 0.445823337329518 496 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2267 7931562 200 µM 0.136041889546483 0.423294420592458 no 1387 0.445894082853933 447 934880 SGTC_1868 st057644 42.7 µM 0.135783964119898 0.423411429400482 no 1388 0.445996034210297 459 688665 SGTC_2973 9094665 17.96 µM 0.135624561915867 0.423483746168036 no 1389 0.446059043630079 508 25237061 YIL048W NEO1 SGTC_2580 diallyl disulphide 81.36 µM 0.135594497061405 0.423497386124716 no 1390 0.446070927991365 487 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2401 5128683 200 µM 0.13523666054691 0.423659738018271 no 1391 0.446212381201326 480 708373 SGTC_2376 9072922 81.32 µM 0.134406613636683 0.424036383557065 no 1392 0.446540526081672 480 17087968 SGTC_3348 9149464 3.537 µM 0.134294778637814 0.424087135583816 no 1393 0.446584740943462 478 1951442 SGTC_2610 ononetin 44.17 µM 0.132164037957171 0.425054330107824 no 1394 0.447427272551949 475 259632 SGTC_228 caffeine 993.056 µM 0.132136506432439 0.425066830295863 no 1395 0.447438160552561 470 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1936 st074407 74.3 µM 0.131795218437278 0.425221792154118 no 1396 0.447573134347635 494 809813 SGTC_1792 st045773 43.6 µM 0.131698540502154 0.425265690884057 no 1397 0.447611369986836 489 2919270 SGTC_3149 9097855 49.47 µM 0.131354904480291 0.425421733828474 no 1398 0.447747280250755 521 25236625 YMR079W SEC14 SGTC_1786 berberine 21.6 µM 0.131173321760945 0.425504194112257 no 1399 0.44781909986629 492 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2761 levamisole 97.89 µM 0.130233767429373 0.425930916183807 no 1400 0.448190739764487 483 26879 An alkaline phosphatase inhibitor. SGTC_2626 ethyl orsellinate 100 µM 0.129315758287678 0.42634793676486 no 1401 0.448553901408906 493 75653 A natural product. SGTC_1638 st008370 60.6 µM 0.128094491123469 0.426902844828334 no 1402 0.449037097790901 485 24207134 SGTC_102 gallobenzophenone 83.616 µM 0.127245623620144 0.427288630687973 no 1403 0.449372998204379 483 70837 SGTC_1672 st016598 6.51 µM 0.127108352525846 0.427351022993239 no 1404 0.449427320363682 491 4665860 YNL267W PIK1 SGTC_2638 epoxomicin 18 µM 0.126553157896938 0.427603387960485 no 1405 0.449647036663724 489 9915668 A protesome inhibitor. SGTC_1133 3473-0247 50 µM 0.126058702883016 0.42782816854206 no 1406 0.449842728476279 494 711311 SGTC_1993 st073995 70.8 µM 0.124322874753393 0.428617465681922 no 1407 0.450529818184302 489 3098394 SGTC_1931 st074438 57.1 µM 0.120976747851349 0.430139783845741 no 1408 0.451854726216704 507 2787313 SGTC_1676 st018489 23.4 µM 0.120953495397422 0.430150366195257 no 1409 0.451863934982719 504 3696235 SGTC_527 4476-4215 268 µM 0.120340905425363 0.430429178097193 no 1410 0.452106550850778 500 4418754 SGTC_2289 7946404 165.07 µM 0.119973809908004 0.430596273204142 no 1411 0.4522519473729 473 1246120 YPR165W RHO1 SGTC_1773 st048542 73.5835 µM 0.119926556446067 0.430617783011634 no 1412 0.452270663645974 494 3237138 SGTC_1017 4239-0030 168 µM 0.119189871351749 0.430953149140558 no 1413 0.452562465468446 483 1149593 SGTC_2954 9074818 52.69 µM 0.119127247459596 0.430981660137476 no 1414 0.452587272048794 501 16648742 SGTC_2127 5253358 187.912 µM 0.11757840591006 0.43168692070022 no 1415 0.453200857914975 486 20612 SGTC_800 3448-7362 155 µM 0.117577405465299 0.431687376320505 no 1416 0.453201254285374 492 15991913 SGTC_134 0269-0018 6.916 µM 0.116058238519355 0.432379336383072 no 1417 0.453803192960706 489 4378915 SGTC_3265 9137266 49.47 µM 0.11538909252186 0.432684189303395 no 1418 0.454068362060194 485 17224265 SGTC_319 1348-1596 45.5 µM 0.112714324731276 0.433903172016853 no 1419 0.455128522066179 490 5380505 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.112354008095918 0.434067428888721 no 1420 0.455271360288827 503 23665772 A membrane-active detergent. SGTC_2593 nobiletin 86.24 µM 0.111970570583368 0.434242238335367 no 1421 0.455423370536702 473 72344 An anti-infammatory. SGTC_2664 lyso-paf C-16 73.48 µM 0.111739167542767 0.434347741377604 no 1422 0.455515111286611 480 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2285 7945142 200 µM 0.110410807860451 0.434953467515137 no 1423 0.456041791051041 501 2970608 SGTC_1948 st076329 66.6 µM 0.109093203121469 0.435554440296763 no 1424 0.456564282918743 506 24208413 SGTC_126 0417-1624 672.48 µM 0.108171968743235 0.43597471307945 no 1425 0.456929640079845 503 41912 YDL195W SEC31 SGTC_2835 9006588 71.43 µM 0.107737571188735 0.436172913027771 no 1426 0.457101932729392 430 2345538 SGTC_819 1013-0258 27.7 µM 0.105848819736182 0.437034867966871 no 1427 0.457851150889189 486 5753198 SGTC_2418 pentamidine 31.67 µM 0.105614763524598 0.437141703299472 no 1428 0.45794400533475 498 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2000 st075254 36.4 µM 0.105188031174471 0.437336497755986 no 1429 0.458113303886374 469 17234175 SGTC_317 4495-0002 170 µM 0.104398241239545 0.437697060500986 no 1430 0.458426659172215 490 15991618 SGTC_3259 9138485 49.47 µM 0.103666493441589 0.438031171455986 no 1431 0.458717008853546 450 17646153 SGTC_3246 9135460 32.98 µM 0.102375284797709 0.438620835957398 no 1432 0.459229400229001 509 41446951 SGTC_195 4234-0266 16.654 µM 0.102129799203768 0.438732958888694 no 1433 0.459326824165802 513 2303354 SGTC_789 1309-1135 70.6 µM 0.101787946068488 0.438889104857596 no 1434 0.459462496798565 466 3092424 SGTC_2836 9010338 19.48 µM 0.0998655292992104 0.439767370746105 no 1435 0.460225541568943 507 2994051 SGTC_2907 7721985 69.9 µM 0.0992890613212731 0.440030791060704 no 1436 0.460454381650717 484 3267881 SGTC_3013 9080133 71.4286 µM 0.098223095142494 0.440517960205414 no 1437 0.460877571931986 491 17050193 SGTC_1438 4092-1045 4 µM 0.0971529041115661 0.441007150783073 no 1438 0.461302484060875 506 1351342 SGTC_1259 0671-0132 43 µM 0.096263431562893 0.441413802427044 no 1439 0.46165567677643 483 X1259 SGTC_2054 5233173 129 µM 0.0948387440741639 0.442065273719399 no 1440 0.462221456114602 492 6889 SGTC_2046 4110841 106 µM 0.0940459634010317 0.44242785899599 no 1441 0.462536322497161 509 44119630 YMR134W ERG29 SGTC_3083 9117465 49.47 µM 0.0934373029071808 0.442706268020911 no 1442 0.462778078347864 504 16420915 SGTC_1029 k015-0030 64.7 µM 0.0931613946752017 0.4428324812718 no 1443 0.462887671774527 493 2208316 SGTC_411 enrofloxacin 100 µM 0.0931412011690933 0.442841718948185 no 1444 0.462895692941808 511 71188 A bacterial gyrase inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0924606594452239 0.443153056188482 no 1445 0.463166023250032 490 5379071 SGTC_3042 9091578 49.47 µM 0.0919965086866251 0.443365418077337 no 1446 0.463350406747181 494 25236497 SGTC_2462 5162487 171.77 µM 0.0919932013828683 0.443366931319286 no 1447 0.463351720599104 508 2259986 SGTC_1130 3454-2858 15.9 µM 0.0919324818517756 0.443394713414208 no 1448 0.463375841972133 521 715628 YIL048W NEO1 SGTC_2814 7977482 42.97 µM 0.0917290033162832 0.44348781662195 no 1449 0.463456676608781 514 6456762 SGTC_3113 9123498 49.47 µM 0.0909199721543542 0.443858026018157 no 1450 0.463778090217404 512 8897275 SGTC_2414 st077232 92.9 µM 0.0907048842177464 0.443956457648552 no 1451 0.463863544794122 507 729801 SGTC_343 4130-2827 29.8 µM 0.0899281070589296 0.444311966312731 no 1452 0.464172172717384 470 1118244 SGTC_2827 7993847 71.43 µM 0.0892427574514831 0.44462566842267 no 1453 0.464444492693164 507 2985692 SGTC_294 k038-0071 157 µM 0.0867312157504643 0.445775560545307 no 1454 0.465442581660713 499 24152826 SGTC_2851 9015922 71.43 µM 0.0863568898077564 0.445946982411347 no 1455 0.465591357902897 524 2996893 SGTC_2457 5731572 11.68 µM 0.0854394186427757 0.446367179285087 no 1456 0.465956028086002 516 2865357 SGTC_1840 st055363 71 µM 0.0845709053338144 0.446765009229375 no 1457 0.466301265178783 482 676033 SGTC_2866 9034245 58.44 µM 0.0840828469702691 0.446988592074649 no 1458 0.466495281239347 509 6462273 SGTC_1005 4092-0690 4.4 µM 0.0832082763256755 0.447389280920102 no 1459 0.466842966003529 506 1529343 SGTC_799 1310-0557 151 µM 0.0822723463194121 0.447818141334305 no 1460 0.467215072146833 514 5354492 SGTC_1143 3454-2408 5.08 µM 0.0822550596291673 0.447826062990362 no 1461 0.467221945242861 513 X1143 SGTC_2603 homopterocarpin 100 µM 0.0821479018710182 0.447875168684731 no 1462 0.4672645508151 506 101795 A weak amylase inhibitor. SGTC_176 1486-1328 72.834 µM 0.0801819601125508 0.448776214456321 no 1463 0.46804626885262 493 22310231 SGTC_1802 st050112 57.9 µM 0.0801666108432168 0.448783250498997 no 1464 0.468052372676139 507 4662563 SGTC_1209 2323-2347 50.3 µM 0.0800405971498446 0.448841015272635 no 1465 0.468102483836804 509 5412760 SGTC_1813 st051246 8.6015 µM 0.0797530998115091 0.448972808330521 no 1466 0.468216813186137 509 5291959 SGTC_2152 5568786 200 µM 0.0793184018849656 0.449172091016533 no 1467 0.46838968491352 514 5399883 SGTC_467 ro 31-8220 72.8 µM 0.0784039668307676 0.44959134593396 no 1468 0.468753359086086 508 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_222 nsc-310342 10.666 µM 0.0783907050613365 0.449597426673796 no 1469 0.468758633532944 519 432556 SGTC_2344 7990960 76.95 µM 0.0782656241797007 0.449654778901396 no 1470 0.468808380743689 502 140813 SGTC_1856 st057054 55.7 µM 0.078257348619814 0.449658573457598 no 1471 0.468811672119364 507 1266018 SGTC_572 0960-0087 17.7 µM 0.0782007815533453 0.449684511029904 no 1472 0.468834170166797 509 6796365 SGTC_772 k072-0172 35.3 µM 0.0776436008861574 0.449940005322699 no 1473 0.469055779276975 503 5861980 SGTC_754 3474-0146 171 µM 0.0770733515088333 0.450201513737847 no 1474 0.469282596170526 516 24762078 SGTC_2704 st078022 71.1 µM 0.0769184243444729 0.450272564915946 no 1475 0.469344220230701 505 54697681 SGTC_2080 5212524 12.4 µM 0.0768260147827313 0.450314945642715 no 1476 0.469380977545674 516 260183 SGTC_717 1532-0246 73.2 µM 0.076611773799057 0.450413202681775 no 1477 0.469466196173289 490 9561992 SGTC_3267 9137951 49.47 µM 0.0764015057150327 0.450509640590866 no 1478 0.46954983586086 513 16643986 SGTC_1481 3346-2004 36 µM 0.0759424943652623 0.450720172911984 no 1479 0.469732424419509 515 2770522 SGTC_541 4513-1321 94 µM 0.0756972080764496 0.450832682772144 no 1480 0.469829998627246 502 747515 SGTC_2934 9036370 36.88 µM 0.074878666276268 0.451208166555496 no 1481 0.470155625370824 505 6462800 SGTC_432 NS 1619 61.3 µM 0.0738942696020441 0.451659789550329 no 1482 0.470547257789875 502 4552 A K+/calcium channel activator. SGTC_740 k014-0057 261 µM 0.0737531795739023 0.451724524187045 no 1483 0.47060339139634 523 4012779 SGTC_2998 9066762 71.4286 µM 0.0734218446628431 0.451876551633806 no 1484 0.47073521748991 520 4945196 SGTC_2655 perillic acid 100 µM 0.073107379441766 0.452020845235014 no 1485 0.470860334714708 517 5702197 An apoptosis inducer. SGTC_908 3448-7491 47.7 µM 0.0729893692218981 0.452074996324225 no 1486 0.470907288539309 513 1203031 SGTC_2557 derrustone 83.84 µM 0.0724611530806484 0.452317388612008 no 1487 0.471117459759298 513 629853 An antioxidant. SGTC_2141 5621638 7.665 µM 0.0703454107231038 0.453288455617514 no 1488 0.471959369736651 518 2856238 SGTC_2569 tetrandrine 100 µM 0.0691975075947007 0.453815428567118 no 1489 0.472416203502707 498 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1709 st033179 39.1045 µM 0.0667674412786272 0.454931277000491 no 1490 0.473383421822319 526 573381 SGTC_2349 9023730 187.07 µM 0.0665242748988877 0.455042954920768 no 1491 0.473480215969406 509 4126287 SGTC_1447 4239-0816 81.9 µM 0.0662769963751921 0.455156525050521 no 1492 0.47357864859103 488 1341554 SGTC_1053 3366-3204 134 µM 0.0660953885292025 0.455239936273183 no 1493 0.473650941122844 508 3632071 YPR165W RHO1 SGTC_342 k048-0088 23.3 µM 0.0648857277422018 0.455795575243703 no 1494 0.474132492129016 522 6820570 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0647063926487366 0.455877957430815 no 1495 0.474203886447067 519 6708760 SGTC_3333 9141820 12.094 µM 0.0641697898060694 0.456124471062519 no 1496 0.474417516021926 516 1939433 SGTC_1817 st052116 64.4 µM 0.0636422336821071 0.456366845126327 no 1497 0.47462755113501 490 4361398 SGTC_788 1182-0090 188 µM 0.06352658973096 0.456419977370157 no 1498 0.47467359322886 485 5715185 SGTC_1377 2944-0135 198 µM 0.0633886500088073 0.456483354353697 no 1499 0.47472851252831 505 1894137 SGTC_2308 7584454 197.62 µM 0.0625493409561983 0.456869002218243 no 1500 0.47506268521564 506 893577 SGTC_513 4245-1575 41.7 µM 0.0609355947328551 0.457610604284541 no 1501 0.475705250803861 509 719745 SGTC_3045 9092950 49.47 µM 0.0600727336562875 0.458007195491248 no 1502 0.476048853061194 509 44120432 SGTC_2795 7780010 54.55 µM 0.0586333308381483 0.458668871675826 no 1503 0.47662208108593 515 953673 SGTC_2467 5474540 200 µM 0.0584770388251831 0.458740724162678 no 1504 0.476684325776919 523 5413519 SGTC_2323 6148992 148.28 µM 0.0584030231367341 0.458774752035989 no 1505 0.476713803384934 506 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1120 ficusin 1.78878 µM 0.0583780196468708 0.458786247175146 no 1506 0.476723761344123 503 6199 A DNA cross-linker. SGTC_2587 piperic acid 92.2 µM 0.0580342001517207 0.458944318718451 no 1507 0.476860693320884 531 5370536 SGTC_2539 epi(13)torulosol 80 µM 0.0576072683037952 0.45914061032656 no 1508 0.47703073001038 513 6708597 SGTC_597 k018-0003 82.8 µM 0.0573265392546628 0.459269687311065 no 1509 0.477142539921496 519 6786234 SGTC_3233 9132340 49.47 µM 0.0568869917570382 0.459471796374765 no 1510 0.477317608303285 526 17682950 SGTC_1613 st002381 52.1 µM 0.055595296603886 0.460065793289426 no 1511 0.477832105739024 530 551167 SGTC_2963 9082507 9 µM 0.0554561932331034 0.460129766488122 no 1512 0.477887514473495 513 16459611 SGTC_2788 5282734 71.43 µM 0.0545218444879301 0.460559497178783 no 1513 0.478259702543782 511 743706 SGTC_2010 4012422 159 µM 0.0543422899366258 0.460642084164397 no 1514 0.478331228407115 509 952393 SGTC_3018 9082602 49.47 µM 0.052949647744159 0.461282694065298 no 1515 0.478886013334769 516 17332089 SGTC_1940 st075990 51.1 µM 0.0517777697866641 0.461821831208199 no 1516 0.479352884463332 527 1084979 SGTC_1973 st070275 50.2 µM 0.0513085322872685 0.462037729528405 no 1517 0.479539834639735 526 17118334 SGTC_591 4299-0174 154 µM 0.0506409420464934 0.462344910115439 no 1518 0.479805818813442 526 5509088 SGTC_375 3970-0961 9.27 µM 0.0500463708742441 0.462618511103066 no 1519 0.480042717990419 524 2898222 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0500241882452087 0.462628719120978 no 1520 0.48005155650836 518 165506 SGTC_3221 9128209 49.47 µM 0.0494801275935692 0.462879093024354 no 1521 0.480268336840928 526 16460723 SGTC_65 0798-0905 34.986 µM 0.0493799419028274 0.462925199568412 no 1522 0.480308256350803 525 3602145 SGTC_1166 k206-0078 225 µM 0.0486108054576552 0.463279181066272 no 1523 0.480614729318458 521 5404595 SGTC_2961 9083290 32.55 µM 0.0484300213359741 0.463362388003903 no 1524 0.480686766901659 533 17741490 SGTC_2174 5790901 200 µM 0.0470945351573472 0.463977102656432 no 1525 0.481218941409772 532 786020 SGTC_872 0588-0139 234 µM 0.0470897496331962 0.463979305554192 no 1526 0.481220848441933 531 2047100 SGTC_2533 agelasine 13.65 µM 0.0470681543682986 0.463989246414356 no 1527 0.481229454163891 520 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3121 9125696 49.47 µM 0.0467151708024729 0.464151737081235 no 1528 0.481370119497374 538 1235365 SGTC_1977 st070720 65.3 µM 0.0467141453052896 0.464152209162138 no 1529 0.481370528165406 498 682188 SGTC_1117 retinoic acid 1.10837 µM 0.0464674552338311 0.464265772783615 no 1530 0.481468836507802 523 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1721 st082152 9.2685 µM 0.0460559111320213 0.464455233330781 no 1531 0.481632843256202 523 5296051 SGTC_3140 9094243 49.47 µM 0.0452785043696053 0.464813146240719 no 1532 0.481942660445588 533 19291112 SGTC_3128 9127691 49.47 µM 0.0452608216103442 0.464821287597893 no 1533 0.481949707621153 530 41316314 SGTC_2037 5169046 200 µM 0.0452222723709505 0.464839036187052 no 1534 0.481965070811905 520 5718022 SGTC_2164 5685496 200 µM 0.042559830853471 0.466065027466283 no 1535 0.483026208396129 519 759046 SGTC_2444 5485484 36.41 µM 0.0420050267630804 0.466320542553953 no 1536 0.483247345439093 523 6790631 SGTC_2313 7726885 200 µM 0.0419017182294839 0.466368122847323 no 1537 0.483288523326802 529 726423 SGTC_755 1995-0008 37.3 µM 0.0417979137430771 0.466415932043332 no 1538 0.483329899076546 530 689533 SGTC_1793 st048256 72.231 µM 0.0408221151469543 0.466865378857244 no 1539 0.483718854357191 532 672022 SGTC_2149 5554786 194.827 µM 0.040391845192902 0.467063572000892 no 1540 0.483890365769334 523 745063 YPR165W RHO1 SGTC_2784 7567673 72.73 µM 0.039016884148716 0.467696968083533 no 1541 0.48443846362956 538 3471247 SGTC_797 k781-0471 270 µM 0.0389381324639055 0.467733248700371 no 1542 0.484469857149973 514 23738129 SGTC_3336 9143619 71.43 µM 0.0375493604322737 0.46837309472789 no 1543 0.485023491969943 538 45595730 SGTC_3231 9132313 49.47 µM 0.0375446196242735 0.4683752790913 no 1544 0.485025381946006 525 4905967 SGTC_1779 st039427 55 µM 0.0375157134663913 0.468388597844397 no 1545 0.485036905715998 528 1124498 SGTC_1357 1503-1303 39.5 µM 0.0373057789955761 0.468485327961701 no 1546 0.485120598864913 532 292895 SGTC_3247 9135149 49.47 µM 0.0371090392100895 0.468575980140035 no 1547 0.485199032373327 530 8934436 YOR116C RPO31 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0369675282856428 0.468641185415037 no 1548 0.485255448354212 517 6857784 SGTC_2194 5927483 104.545 µM 0.0350910919167432 0.469505886915619 no 1549 0.486003552329885 516 760979 SGTC_2819 7996655 46.38 µM 0.0344052249665999 0.469821985000936 no 1550 0.486277008509612 536 6456960 SGTC_1320 1313-0481 95.3 µM 0.0338545603394715 0.470075785656918 no 1551 0.486496563997119 533 6813365 YLR208W SEC13 SGTC_3222 9128301 49.47 µM 0.0336508269251154 0.470169689225987 no 1552 0.486577795585402 538 4911358 SGTC_2099 5377090 177.372 µM 0.0330195472192308 0.470460665348201 no 1553 0.486829499856542 527 2243829 SGTC_1187 1391-0724 117 µM 0.0325417693669831 0.470680898266163 no 1554 0.487020003258362 517 6997986 SGTC_381 3461-2219 42.7 µM 0.0308626622558528 0.471454957657797 no 1555 0.487689533466016 526 2883159 SGTC_1697 st025554 27.742 µM 0.0307840275206793 0.471491210516106 no 1556 0.487720889287791 533 1269519 SGTC_1152 3909-8331 15.9 µM 0.0303724122712197 0.471680980747356 no 1557 0.487885023260068 533 16001939 SGTC_503 tyrphostin 8 294 µM 0.0301880029968535 0.471766002500543 no 1558 0.487958558196918 538 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1962 st076595 64.5 µM 0.0299708889354175 0.471866104419401 no 1559 0.488045135000484 530 279619 SGTC_3218 9131285 49.47 µM 0.0295662269364395 0.472052681332327 no 1560 0.488206500265916 530 17156417 SGTC_2231 micatex 6.853 µM 0.0288986314050111 0.472360502008293 no 1561 0.488472718573945 526 20737 An antifungal of unknown mechanism. SGTC_1712 st032288 53.4 µM 0.028567477641846 0.472513199363938 no 1562 0.488604775287283 532 2883011 SGTC_2368 9071271 200 µM 0.0274772202913565 0.473015953206281 no 1563 0.489039554280324 536 27209959 SGTC_2167 5876490 200 µM 0.0272885938187079 0.473102939516568 no 1564 0.489114777148127 537 686534 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0270080453561613 0.473232318614663 no 1565 0.489226658553528 535 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_144 4161-2749 112.381 µM 0.0266143461431428 0.473413883623756 no 1566 0.489383665372797 535 797501 YMR168C CEP3 SGTC_531 3788-1495 174 µM 0.0265073190369766 0.473463243016426 no 1567 0.489426347952113 531 2896655 SGTC_230 MPP+ 141.667 µM 0.0263958426453529 0.473514654790008 no 1568 0.48947080504225 528 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2191 5911152 200 µM 0.0259859828826746 0.473703681713824 no 1569 0.489634259357978 535 2875902 SGTC_904 1141-0088 396 µM 0.0251022179563889 0.474111293330765 no 1570 0.489986715533768 530 1378119 SGTC_2970 9090938 41.86 µM 0.0241980157394409 0.474528359118942 no 1571 0.490347330439312 512 17217104 SGTC_3182 9108849 49.47 µM 0.0237289499645296 0.474744728038697 no 1572 0.490534406885601 540 17133045 SGTC_570 0987-0065 62.6 µM 0.0234525719028778 0.474872218176845 no 1573 0.490644635102827 539 3104428 SGTC_3185 9108267 49.47 µM 0.0233095357878438 0.474938200163401 no 1574 0.490701682661359 530 4910486 SGTC_2102 5377816 72.7585 µM 0.0229631395112473 0.47509799422182 no 1575 0.490839837799687 537 1379702 SGTC_2767 sibutramine 71.45 µM 0.0228062741716506 0.475170358181585 no 1576 0.490902401631127 540 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1417 3966-0327 90.4 µM 0.0227369749490157 0.475202327048079 no 1577 0.490930040853984 536 651118 SGTC_2125 5246583 200 µM 0.0226988641335669 0.475219908259539 no 1578 0.490945240946686 538 835267 SGTC_2461 5755302 26.15 µM 0.022387607904122 0.475363498215418 no 1579 0.491069382667886 536 2788904 SGTC_1470 k295-0292 231 µM 0.0221254678367075 0.475484432192004 no 1580 0.491173935525347 538 5045612 SGTC_3306 9127676 59.7925 µM 0.0193116443752716 0.476782682984957 no 1581 0.492296247396684 539 41905287 SGTC_2969 9091408 28.7 µM 0.0192371350574367 0.476817063740698 no 1582 0.492325966792923 518 4286311 SGTC_2793 7325131 81.82 µM 0.0191298851768923 0.476866552242576 no 1583 0.492368745432675 533 4176441 SGTC_401 neomycin 50 µM 0.0189739268176058 0.476938517020292 no 1584 0.492430952525275 522 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1222 0366-0074 1.18 µM 0.0185181568826936 0.477148829908537 no 1585 0.492612746475591 534 286520 SGTC_1345 1488-0192 31.4 µM 0.0184755237576098 0.477168503089593 no 1586 0.492629751722453 538 658348 SGTC_1587 estradiol valerate 56.1 µM 0.0180275150659886 0.477375241374499 no 1587 0.492808451563492 533 13791 A steroid. SGTC_150 3970-0969 77.2 µM 0.0177855867362449 0.477486884261767 no 1588 0.492904951530483 538 6615640 SGTC_2878 9043973 25.97 µM 0.0176731011578928 0.477538793686611 no 1589 0.492949819731342 536 6465167 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0173919186944304 0.477668554385359 no 1590 0.493061978064717 538 804 An inhibitor of viral and cellular DNA polymerases. SGTC_112 phenothiazine 287.218 µM 0.0159050123346354 0.478354774223142 no 1591 0.493655085622084 540 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_353 1988-1175 58.3 µM 0.0154479963541624 0.478565703944177 no 1592 0.493837386216112 530 2788357 SGTC_1897 st060201 15 µM 0.0148009023702253 0.478864371924631 no 1593 0.49409550983675 535 611878 SGTC_136 0097-0015 404.482 µM 0.0146734789241729 0.47892318596515 no 1594 0.49414633891691 539 4861337 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0144057766982061 0.479046749095373 no 1595 0.494253125365121 539 15053 SGTC_1094 duloxetine 25.4 µM 0.0135600938887492 0.479437103494651 no 1596 0.49459047100263 543 60834 A selective serotonin reuptake inhibitor. SGTC_373 0844-0104 25.9 µM 0.0130391828466344 0.479677557995987 no 1597 0.494798266061062 540 5375804 SGTC_2481 5478948 45.16 µM 0.0121409925828483 0.480092183329655 no 1598 0.495156563723026 540 77792 SGTC_577 r071-0003 38.6 µM 0.011563699061897 0.480358686728328 no 1599 0.495386854337575 543 4568517 YMR134W ERG29 SGTC_2229 7354935 190 µM 0.0107593637420265 0.480730016951126 no 1600 0.495707717708476 545 318112 SGTC_3155 9099265 49.47 µM 0.0104470798327442 0.480874190767204 no 1601 0.495832293959726 542 25236499 SGTC_614 0462-0418 107 µM 0.0101777898647264 0.480998517345381 no 1602 0.49593971940103 537 5188303 SGTC_1253 0550-0034 176 µM 0.00867390239180283 0.481692870145236 no 1603 0.49653965699062 545 5969915 SGTC_1006 4099-6547 255 µM 0.00797269006978182 0.482016642696276 no 1604 0.496819390537927 541 3146833 SGTC_1249 0481-0015 10.2 µM 0.00729997164329602 0.482327269839279 no 1605 0.497087758531138 542 4227577 SGTC_3305 9127027 53.8275 µM 0.00709878948920751 0.482420167614919 no 1606 0.497168016518374 540 41905295 SGTC_855 0428-0020 25 µM 0.00705945279684561 0.482438331818965 no 1607 0.497183709194912 545 6812414 SGTC_571 k831-0106 44.2 µM 0.00635967504097339 0.482761468906745 no 1608 0.497462873839095 543 4783639 SGTC_3199 9111318 49.47 µM 0.00585522462751473 0.48299441652475 no 1609 0.497664116681947 545 8548020 SGTC_1617 st002906 78 µM 0.00575242415427029 0.483041888952645 no 1610 0.497705127446435 539 5150859 SGTC_2978 9011784 42.97 µM 0.00556967414655422 0.483126282022708 no 1611 0.497778032982926 543 2994934 SGTC_1471 k673-0312 37 µM 0.00480683431798525 0.483478565888736 no 1612 0.498082357940404 543 24099884 SGTC_781 4335-2806 94.4 µM 0.00438654040146804 0.483672665590282 no 1613 0.498250029181247 542 845254 SGTC_2261 9010538 184.68 µM 0.00424010120430025 0.483740294900053 no 1614 0.498308449425004 546 6457250 SGTC_2732 terfenadine 20 µM 0.0019766290515354 0.484785681656105 no 1615 0.499211439612165 546 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2116 5511452 16.8835 µM 0.00135045698847976 0.485074898589305 no 1616 0.499461245773189 547 870744 SGTC_1490 4089-0339 670 nM 0.00124701577783388 0.485122676871348 no 1617 0.49950251281083 547 742542 SGTC_3187 9109394 49.47 µM -0.000771961400637495 0.48605526067222 no 1618 0.499692031989035 549 17098090 SGTC_2635 hydroquinidine 100 µM -0.000871992415913177 0.486101467927007 no 1619 0.499652125401188 548 442912 An experimental heart treatment. SGTC_1245 0418-0076 17.2 µM -0.00114653121623674 0.486228286394179 no 1620 0.499542600322254 550 6790114 SGTC_2460 5552655 174.22 µM -0.00139938774914779 0.486345090344037 no 1621 0.499441725242399 552 5401989 SGTC_2260 7964312 200 µM -0.00140029399079107 0.486345508973275 no 1622 0.499441363704646 551 231951 SGTC_2730 imipramine 71.33 µM -0.00193135099532447 0.486590828002795 no 1623 0.499229502908677 549 3696 A tricyclic antidepressant. SGTC_449 xestospongin c 11.1929 µM -0.00240960640650772 0.486811759955332 no 1624 0.499038707055562 549 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3067 9117431 49.47 µM -0.00343149794233886 0.487283840214247 no 1625 0.498631033072329 551 17150885 SGTC_1368 1852-0141 284 µM -0.00439456714661849 0.487728762813228 no 1626 0.498246827004097 545 2838987 SGTC_1102 cgs 12066b 26.1 µM -0.00458162134895095 0.487815180657317 no 1627 0.498172203925738 552 6438352 A 5-HT1B full agonist. SGTC_1202 1988-0068 29.6 µM -0.00512980019420861 0.488068439054788 no 1628 0.497953514788015 548 2850480 SGTC_2373 9071805 200 µM -0.00556704272883572 0.488270448377422 no 1629 0.497779082750437 562 10149009 SGTC_2087 5276107 200 µM -0.00648639852771124 0.488695207389115 no 1630 0.49741231952518 551 144405 SGTC_3335 9143315 29.6265 µM -0.00750002867969538 0.489163537700681 no 1631 0.49700794950616 551 4899691 SGTC_2817 7995342 71.43 µM -0.00815637967080404 0.48946680135478 no 1632 0.496746111372669 554 18879975 SGTC_2420 aureobasidin a 50 nM -0.00889706171762311 0.489809037050954 no 1633 0.49645063273619 556 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1116 jasmonic acid  1.58368 µM -0.00901510924591537 0.489863582177945 no 1634 0.496403540474792 552 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1216 1165-0504 9.65 µM -0.00937683395786247 0.490030722138124 no 1635 0.496259239295725 552 6304004 SGTC_1695 st026914 34.495 µM -0.0104073919843053 0.490506915381112 no 1636 0.495848126259761 557 3289191 SGTC_1540 guanosine 70.6 µM -0.0105363498799634 0.490566504334826 no 1637 0.495796682323577 554 6802 Guanosine is a purine nucleoside SGTC_3059 1327-0034 3 µM -0.0111643669828432 0.490856701897402 no 1638 0.495546154500329 555 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2404 5161160 200 µM -0.0117298559953104 0.491118010284846 no 1639 0.495320571807411 555 2831543 SGTC_1855 st056195 39.6 µM -0.0121022926996713 0.491290112684376 no 1640 0.495172001608452 550 4028379 SGTC_1173 0443-0020 122 µM -0.0121961119728685 0.49133346667592 no 1641 0.495134575895849 554 5331295 SGTC_1462 k081-0014 26.5 µM -0.0122965746853345 0.491379890721713 no 1642 0.495094500077516 548 3270634 SGTC_1229 0139-0193 12.2 µM -0.0123463044093664 0.491402870982483 no 1643 0.495074662293931 553 3090752 SGTC_169 k015-0017 16.025 µM -0.0126398287041936 0.491538510054467 no 1644 0.494957572180696 555 1840002 SGTC_1443 4112-3303 14 µM -0.0129855356959561 0.491698264270165 no 1645 0.494819666365845 549 704433 SGTC_1917 st066507 28.5 µM -0.0131251883657622 0.491762799365808 no 1646 0.494763957759093 551 3156428 SGTC_422 cantharidin 155 µM -0.0133597163388224 0.491871177908214 no 1647 0.494670402838291 554 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1396 3511-0007 98.6 µM -0.0143729980936904 0.492339435881621 no 1648 0.494266200782622 553 X1396 SGTC_330 1488-0319 80.1 µM -0.0150917005662254 0.492671569253526 no 1649 0.493979511099025 560 6846614 SGTC_846 0335-0850 148 µM -0.0152618542085119 0.492750202966165 no 1650 0.49391163743431 558 6819598 SGTC_2047 4141938 200 µM -0.0155304215388559 0.492874317521297 no 1651 0.4938045072693 556 3807862 SGTC_3232 9132874 49.47 µM -0.0165955804872412 0.493366572189589 no 1652 0.4933796251671 555 3784940 SGTC_2330 7979373 200 µM -0.0170030528529054 0.493554884988626 no 1653 0.49321709015016 555 1863007 SGTC_3154 9100113 49.47 µM -0.0171644289161524 0.493629465115947 no 1654 0.493152719809618 562 25237525 SGTC_2182 6325192 200 µM -0.0172453484949912 0.493666862273398 no 1655 0.493120442345866 553 736248 SGTC_551 k048-0028 34.9 µM -0.0178709036987803 0.493955965810111 no 1656 0.492870920395668 560 6836383 SGTC_2003 4023581 200 µM -0.0180893368793841 0.494056916577209 no 1657 0.492783792249393 560 16641307 SGTC_1698 5-fluorocytosine 1.055 µM -0.0192730791068942 0.494603999650707 no 1658 0.492311629849889 557 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1014 4130-3005 69.3 µM -0.0200903403644306 0.494981714387875 no 1659 0.491985652932099 563 743608 SGTC_1623 st003709 20.3 µM -0.0207847213319793 0.495302640924256 no 1660 0.491708692859137 555 16192618 SGTC_3112 9123419 49.47 µM -0.0207901528874285 0.495305151273571 no 1661 0.491706526450142 556 17015854 SGTC_278 4092-0821 23.9 µM -0.0212130005311779 0.495500583016777 no 1662 0.491537871846165 567 877900 SGTC_2985 9022375 71.43 µM -0.0213928932227343 0.495583726159285 no 1663 0.491466121328262 582 4939335 SGTC_204 PMA1.184 62.41 µM -0.0214055246122308 0.495589564165888 no 1664 0.491461083286589 565 2252213 YGL008C PMA1 SGTC_1475 4092-1048 11.7 µM -0.0215323217147183 0.495648167614081 no 1665 0.491410510217686 560 2881759 SGTC_166 k072-0058 166.424 µM -0.0222594581890507 0.495984239408549 no 1666 0.491120494270346 553 5846229 SGTC_1487 3970-0795 2.82 µM -0.0250884114429323 0.497291764963154 no 1667 0.489992221801603 561 3765103 SGTC_1583 clindamycin 39.6 µM -0.0253205191337137 0.497399045254826 no 1668 0.489899653637683 572 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3003 9075612 71.4286 µM -0.0253497515473354 0.497412556504633 no 1669 0.489887995334084 564 6501993 SGTC_1351 1496-0003 46.5 µM -0.026330261430045 0.497865750741273 no 1670 0.48949695907159 561 3891978 SGTC_1916 st067606 49.2 µM -0.02651776754703 0.497952416891467 no 1671 0.489422181064427 561 19590279 SGTC_2903 5923464 63.88 µM -0.0268975133352092 0.498127937353133 no 1672 0.489270738436127 567 2876576 SGTC_1545 lovastatin 49.4 µM -0.0275540929681248 0.498431412680936 no 1673 0.489008898126619 563 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2265 7929201 200 µM -0.0281243532228952 0.498694991379957 no 1674 0.488781485345309 558 1265108 SGTC_1905 st060207 84.5 µM -0.0286901133975588 0.498956490670395 no 1675 0.488555870744653 550 1948547 SGTC_1324 1418-0026 34.4 µM -0.0291399577093772 0.49916441296281 no 1676 0.488376483837098 596 1372513 SGTC_1505 k297-0037 20.6 µM -0.0301941467084969 0.499651669871488 no 1677 0.487956108327369 562 4089396 SGTC_1859 st055998 20 µM -0.0306473901233495 0.499861163803344 no 1678 0.487775374014627 580 676301 SGTC_438 sphingosine 6.67 µM -0.0312481386045861 0.499861163803344 no 1679 0.487535824792472 563 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2693 st077581 40.7 µM -0.0317590210576484 0.499625028500046 no 1680 0.487332113298268 569 25238761 SGTC_1279 0874-0590 65.2 µM -0.0328056893834858 0.4991412477686 no 1681 0.48691477059219 563 3523074 SGTC_2544 sphondin 68.51 µM -0.0333883889413828 0.498871918615997 no 1682 0.486682434392076 560 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1103 duloxetine 36.1 µM -0.0338776519124864 0.498645777114449 no 1683 0.486487357073607 578 60835 A selective serotonin reuptake inhibitor. SGTC_2653 dihydrofissinolide 100 µM -0.0341411104439846 0.498524004518717 no 1684 0.486382313093064 560 6857746 SGTC_3047 9092122 49.47 µM -0.0347499388904269 0.498242599789651 no 1685 0.486139569737526 569 17173831 SGTC_1631 benzylvanillin 81.9 µM -0.0350061259744835 0.49812418859651 no 1686 0.48603742802371 575 75506 SGTC_1711 st032263 62.8 µM -0.0364075348424397 0.497476452286781 no 1687 0.48547870311431 563 3958979 SGTC_2553 4-methylesculetin 85.09 µM -0.0366043406952316 0.497385488394612 no 1688 0.485400241238574 584 5319502 SGTC_54 0159-0055 9 µM -0.0367791958313528 0.497304670262896 no 1689 0.485330531072621 565 3319099 SGTC_3122 9126309 49.47 µM -0.0381919897979376 0.496651680526826 no 1690 0.484767303726698 568 17591206 SGTC_533 1222-0222 6.71 µM -0.0387776363937473 0.496380998707192 no 1691 0.484533837496803 583 3982874 SGTC_748 act1.228 77.9 µM -0.0391074360371625 0.496228568310691 no 1692 0.484402366202881 572 4421505 YNR035C ARC35 SGTC_424 splitomicin 100 mM -0.0391817839681553 0.496194205448253 no 1693 0.484372728385476 589 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_383 2324-0395 7.37 µM -0.0392622758033642 0.49615700296721 no 1694 0.484340641479416 575 3146421 SGTC_1449 4112-4002 201 µM -0.0399049286491277 0.495859976795621 no 1695 0.484084460870438 567 2059539 SGTC_2621 lithochol-11-enic acid 100 µM -0.0410498616275956 0.495330808771773 no 1696 0.483628072752792 573 6708711 SGTC_992 3909-8734 162 µM -0.0412172279525822 0.495253455645852 no 1697 0.48356135971158 575 4288319 SGTC_2526 patulin 37.61 µM -0.0415449852911727 0.495101973752978 no 1698 0.483430715357422 572 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_790 1575-0012 79.1 µM -0.041841885516378 0.494964753916258 no 1699 0.48331237221014 603 378741 YLR208W SEC13 SGTC_339 3091-4833 71.4 µM -0.0422051237263157 0.494796875138961 no 1700 0.483167589029326 565 3240077 SGTC_1206 3978-0017 132 µM -0.0423836470991541 0.494714366849016 no 1701 0.483096432179647 586 3873677 SGTC_2296 7971656 126.45 µM -0.0425700420667456 0.494628220779172 no 1702 0.483022138400046 569 666570 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.04280114848533 0.494521410788465 no 1703 0.482930024235613 565 1241132 A phosphatase inhibitor. SGTC_1506 4226-2149 212 µM -0.0428111644048489 0.494516781759822 no 1704 0.482926032121025 588 991114 SGTC_1452 4194-0072 190 µM -0.0429229991540841 0.494465095466529 no 1705 0.48288145748486 597 1343545 SGTC_3284 9108171 64.8615 µM -0.0430841096191648 0.494390635743459 no 1706 0.482817243112056 561 8687505 SGTC_1966 st070145 16.1 µM -0.0432547211616327 0.494311785161881 no 1707 0.482749242346912 565 3748532 SGTC_2251 lansoprazole 556 µM -0.0435331206700662 0.494183119298014 no 1708 0.482638281533112 591 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1658 st012944 20 µM -0.0440506800967305 0.493943924262967 no 1709 0.482432003085593 574 24207260 SGTC_820 1582-0060 59.9 µM -0.0440517520402354 0.493943428856262 no 1710 0.482431575856729 574 3848840 SGTC_1984 st072354 53.1 µM -0.0441255328220125 0.493909330538852 no 1711 0.4824021701768 576 5762938 SGTC_1845 st056753 3.01 µM -0.0449003398236039 0.493551250661772 no 1712 0.482093372989626 576 5375839 SGTC_1970 st070122 35.8 µM -0.0456450671163176 0.493207077125669 no 1713 0.481796574110068 578 102928 SGTC_2162 5663267 200 µM -0.045948760589791 0.493066727513777 no 1714 0.481675544930972 595 6456493 SGTC_1896 st058441 89 µM -0.0465029902820404 0.492810596732673 no 1715 0.481454675383122 571 688759 SGTC_442 cape 100 µM -0.0465633679201468 0.492782694089335 no 1716 0.481430614254824 566 5281787 SGTC_3276 9139060 49.47 µM -0.0466140612828208 0.492759266919667 no 1717 0.481410412465097 597 4870619 SGTC_2429 5902844 64.44 µM -0.0468548081900058 0.492648009725611 no 1718 0.481314473173263 565 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2558 carylophyllene oxide 100 µM -0.0470460643049763 0.492559624288358 no 1719 0.481238257072274 560 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3075 9116269 49.47 µM -0.0473356341789164 0.492425805682382 no 1720 0.481122863967246 565 17015205 YNL244C SUI1 SGTC_1034 k072-0165 12.7 µM -0.0480754617211563 0.492083913904002 no 1721 0.480828051148449 568 5835461 SGTC_2783 7738165 71.43 µM -0.0482500085710501 0.492003252521249 no 1722 0.480758497746744 573 17201110 SGTC_349 k015-0014 24 µM -0.0489150341488467 0.491695934716469 no 1723 0.480493503843131 571 2196908 SGTC_2673 kobusone 100 µM -0.0490198272270376 0.49164750878525 no 1724 0.480451747545407 569 6710676 An epoxy ketone and protein crosslinker. SGTC_2086 5274770 176.623 µM -0.0490918119023917 0.491614244016931 no 1725 0.480423064348321 572 689278 SGTC_3116 9124943 49.47 µM -0.0490942854338876 0.491613100976732 no 1726 0.480422078740461 564 41905195 YPL160W CDC60 SGTC_2611 pyromycin 23.93 µM -0.0494132191296252 0.49146571955052 no 1727 0.480294996844676 569 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2883 9059145 45.46 µM -0.0506498201360626 0.490894289028309 no 1728 0.479802281507568 563 16476510 SGTC_966 1300-0360 30.2 µM -0.0516844143027721 0.490416219717782 no 1729 0.479390078112568 568 70588 SGTC_954 1189-0853 2.85 µM -0.052589137027343 0.489998173170169 no 1730 0.479029636195457 576 2828194 SGTC_987 1497-1013 404 µM -0.0528419178923099 0.489881372291604 no 1731 0.478928931244115 571 1676435 SGTC_2939 9044578 71.43 µM -0.0530661166917618 0.489777778875661 no 1732 0.478839614180053 573 2653634 SGTC_1255 0566-0045 221 µM -0.0548609323607817 0.488948490842046 no 1733 0.478124628219959 586 2788469 SGTC_2085 5307070 144.047 µM -0.0562494237862562 0.488306976034107 no 1734 0.477571554484867 592 2840351 SGTC_2614 arthonioic acid 13.39 µM -0.0566165300314927 0.488137369537741 no 1735 0.477425333302438 581 6710684 SGTC_1302 1159-0335 255 µM -0.0585971287196378 0.487222352325613 no 1736 0.476636498852471 584 649284 SGTC_3123 9126162 49.47 µM -0.0589699685893735 0.487050111331096 no 1737 0.476488014032287 564 25239884 SGTC_1501 4491-0275 38.4 µM -0.0594366236468334 0.486834533901616 no 1738 0.476302171578456 569 5104718 SGTC_1834 st055981 52.8 µM -0.0597338152675398 0.486697244332454 no 1739 0.476183819561009 573 471719 YDL150W RPC53 SGTC_1898 st060199 18.6 µM -0.0598300366166217 0.486652794602163 no 1740 0.476145501330166 566 688866 SGTC_152 4469-0003 551.229 µM -0.0601142024281088 0.486521524354351 no 1741 0.476032339259262 583 697280 SGTC_2630 antimycin a 100 µM -0.0607333871652795 0.486235497366635 no 1742 0.475785770818255 592 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0607647270589979 0.486221020363166 no 1743 0.475773291058798 579 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_213 1246-0773 967 nM -0.0617887600484835 0.485747993469773 no 1744 0.475365527283347 592 6251622 SGTC_2076 5212012 200 µM -0.0663425962770824 0.483644712766011 no 1745 0.473552535489246 578 604802 SGTC_3028 9087778 49.47 µM -0.0663762742586565 0.483629159536913 no 1746 0.473539129468204 566 17217395 SGTC_2040 5100729 123 µM -0.0671491304145899 0.483272244538969 no 1747 0.473231490855528 580 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_205 1486-1330 71.903 µM -0.0676695708990531 0.483031905907157 no 1748 0.473024336336446 580 4118834 SGTC_593 1203-0218 61.7 µM -0.0679534917626048 0.482900794273713 no 1749 0.472911328426992 577 3666956 SGTC_3063 1327-0034 4 µM -0.068860890808543 0.482481779518307 no 1750 0.472550174601654 577 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2187 6125751 200 µM -0.0704392726796806 0.481752967626945 no 1751 0.4719220168916 592 874498 SGTC_1122 capsaicin 818.572 nM -0.0705300206614565 0.48171106691824 no 1752 0.47188590350353 571 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_930 2810-3379 265 µM -0.0707264667205081 0.481620363344691 no 1753 0.471807728091356 619 1015764 SGTC_3194 9111903 49.47 µM -0.071216230796139 0.481394232384267 no 1754 0.471612831954038 580 17087251 SGTC_1160 4092-0570 10.5 µM -0.0713159349641729 0.481348198298948 no 1755 0.471573156626538 574 4994975 SGTC_2769 toremifene 3.73 µM -0.0714716116793711 0.481276321809508 no 1756 0.471511208680716 577 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2256 7954252 200 µM -0.0719528851172163 0.481054120022575 no 1757 0.471319701420484 603 2972920 SGTC_2321 7390090 138.78 µM -0.071965048916 0.481048504127225 no 1758 0.471314861314355 589 649046 SGTC_753 1322-0200 289 µM -0.0728439182227768 0.480642749623999 no 1759 0.470965161038534 587 5403907 SGTC_1165 k072-0275 30.3 µM -0.0728923853927462 0.480620373984175 no 1760 0.470945876700921 577 6153523 YGL055W OLE1 SGTC_1153 4055-0057 267 µM -0.0732980616033664 0.480433089511015 no 1761 0.470784467084596 576 882706 SGTC_3043 9092303 49.47 µM -0.0736406006260126 0.480274956312522 no 1762 0.470648182098868 589 25236084 SGTC_2676 harmalol 100 µM -0.0740411515064254 0.480090045868977 no 1763 0.470488820468688 587 5459187 A monoamine oxidase inhibitor SGTC_2570 licareol 100 µM -0.0742713260652095 0.479983789943843 no 1764 0.470397246242094 612 443158 SGTC_1853 st056710 91.2 µM -0.0748713593837497 0.479706802112337 no 1765 0.470158532239415 602 269167 SGTC_3139 9095020 49.47 µM -0.0748777189450492 0.479703866459113 no 1766 0.470156002243305 575 25236292 SGTC_1385 3091-4834 14.1 µM -0.0762909031086453 0.479051550526547 no 1767 0.469593831510162 580 4072814 SGTC_1486 3970-0793 4.53 µM -0.076851454904011 0.478792819179881 no 1768 0.469370858322728 595 2844330 SGTC_1067 clotrimazole 1.36 µM -0.0772720001245452 0.478598715893388 no 1769 0.469203582477414 577 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_276 colchicine 750 µM -0.0776032309855092 0.478445839356499 no 1770 0.469071836089938 576 2833 A microtubule depolymerizer. SGTC_3054 9094397 49.47 µM -0.0779524962320939 0.478284642651293 no 1771 0.468932920231327 606 2598354 SGTC_2873 9040596 71.43 µM -0.0781817041521992 0.478178858041491 no 1772 0.468841757718571 571 6463863 SGTC_2403 6032726 181.2 µM -0.0790322610115745 0.47778632041852 no 1773 0.468503481366317 586 2881040 SGTC_2807 7945238 51.95 µM -0.0800402465333298 0.477321156357237 no 1774 0.468102623265218 601 17148797 SGTC_1221 2958-7315 257 µM -0.0805322811488253 0.477094103941447 no 1775 0.467906961479543 593 4562705 SGTC_2328 6201408 200 µM -0.0810940031157346 0.476834902960625 no 1776 0.467683597401205 601 2890418 SGTC_104 0074-0074 590.992 µM -0.0811654086923434 0.47680195427163 no 1777 0.467655204293705 610 3943124 SGTC_1319 1306-0155 43.7 µM -0.0823446703331793 0.47625783045055 no 1778 0.46718631660995 581 3122360 SGTC_3084 9116877 49.47 µM -0.0837219826612972 0.475622380058571 no 1779 0.466638739433965 586 27241325 SGTC_1701 st028638 40.4 µM -0.0840121360894486 0.475488519864944 no 1780 0.466523391339239 592 3490878 SGTC_324 1315-0088 19.6 µM -0.0845750798297937 0.475228817730316 no 1781 0.466299605741102 612 6787421 SGTC_2351 9026858 72.31 µM -0.0852624572234546 0.474911725054718 no 1782 0.466026368802491 599 1409300 SGTC_3098 9119039 49.47 µM -0.0853245150533249 0.474883098061804 no 1783 0.466001701201856 579 17161528 SGTC_2502 avocadyne acetate 18.59 µM -0.0864561577845726 0.474361099339167 no 1784 0.46555190327099 588 3952079 SGTC_3309 9129340 25.759 µM -0.0873968716542782 0.473927204826889 no 1785 0.46517802796192 582 17158987 SGTC_641 4092-0595 30 µM -0.0877883455399919 0.473746650642411 no 1786 0.465022450455974 581 786260 SGTC_1874 staurosporine 7.6 µM -0.0881831303965726 0.473564574845414 no 1787 0.464865562535992 587 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1846 st056244 14.8 µM -0.088288907371673 0.473515791167381 no 1788 0.46482352758083 603 5393182 SGTC_757 1066-0008 322 µM -0.0893198194455613 0.473040361889718 no 1789 0.464413871691325 601 6842497 SGTC_2048 5246248 200 µM -0.089678604938447 0.472874908519947 no 1790 0.464271309105219 584 677046 SGTC_2059 5238311 157 µM -0.0905807093949066 0.472458925197935 no 1791 0.463912880291117 586 703021 SGTC_519 k048-0011 62.8 µM -0.091941168058372 0.471831640039012 no 1792 0.463372391291157 588 6836379 SGTC_588 3970-1144 52.9 µM -0.0922686145661017 0.4716806702022 no 1793 0.463242311958775 585 1888707 SGTC_2277 7947813 106.88 µM -0.0927478979003033 0.471459703049753 no 1794 0.463051921977235 620 1246798 SGTC_3293 9120939 62.045 µM -0.0928227817547079 0.471425179644951 no 1795 0.463022175961083 594 934087 SGTC_2665 lovastatin 100 µM -0.0932566779970122 0.471225146425169 no 1796 0.462849823995786 593 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2129 girgensonine 121.053 µM -0.0936315195645142 0.471052344212899 no 1797 0.462700935301105 592 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_292 k038-0015 474 µM -0.0936850947051058 0.471027646481801 no 1798 0.462679655449457 602 46368540 SGTC_974 1326-0144 138 µM -0.0938425224881494 0.470955074119949 no 1799 0.46261712632293 610 5411856 SGTC_1238 0333-0287 48.8 µM -0.0940412728847938 0.470863453895658 no 1800 0.462538185485839 588 7226 SGTC_3030 9087619 49.47 µM -0.094557843881928 0.470625331530089 no 1801 0.462333017725072 592 25236973 SGTC_1380 2291-0730 164 µM -0.095340572583962 0.47026453919352 no 1802 0.462022158574946 589 2999191 SGTC_3216 9129716 49.47 µM -0.095837876382304 0.470035323773159 no 1803 0.461824667397874 586 8056934 SGTC_478 N-arachidonylglycine 10 µM -0.0959199258288589 0.46999750679906 no 1804 0.461792084512664 585 5283389 SGTC_459 nigericin 15.3 µM -0.0975413989332688 0.469250218205732 no 1805 0.461148229679405 628 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3144 9087057 49.47 µM -0.0976816595938678 0.469185581302656 no 1806 0.461092539711929 621 17249618 SGTC_605 1315-0399 119 µM -0.0989205701384862 0.468614684468109 no 1807 0.460600668199775 592 24020461 SGTC_77 0828-0286 12.516 µM -0.0990310375719818 0.468563783579717 no 1808 0.460556813402295 597 745345 SGTC_3029 9088683 49.47 µM -0.0990773212283783 0.468542457273087 no 1809 0.460538439257419 596 25236615 SGTC_480 am 92016 50 µM -0.0993086405556936 0.468435872689868 no 1810 0.460446609080693 641 2129 K+ channel blocker. SGTC_1323 1348-1351 11.2 µM -0.0997897418992629 0.468214203758631 no 1811 0.460255626088511 584 6989654 SGTC_2021 4019055 173 µM -0.100482885753394 0.467894852929886 no 1812 0.459980484628439 609 44827708 YER133W GLC7 SGTC_2139 5578692 56.4705 µM -0.100515795821895 0.467879690849755 no 1813 0.459967421546848 591 650991 YMR113W FOL3 SGTC_1665 st014639 11.4 µM -0.100875825944377 0.46771382351777 no 1814 0.459824516651745 590 981133 YIL048W NEO1 SGTC_3303 9125618 40.5795 µM -0.101937830061756 0.467224586692526 no 1815 0.459403011151446 611 22695467 SGTC_2564 betulinic acid 100 µM -0.102223885194619 0.467092817194778 no 1816 0.459289484709649 640 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2297 7971671 152.32 µM -0.102234341437292 0.467088000660591 no 1817 0.459285335012913 597 909016 SGTC_918 glabranin 770.725 nM -0.102289706558831 0.467062497507206 no 1818 0.459263362713854 613 124049 Also referred to as licorice root. SGTC_515 4092-1064 102 µM -0.102592670294935 0.466922943981511 no 1819 0.459143130200419 647 717353 SGTC_1248 0469-0687 58.6 µM -0.102889109004115 0.466786400000249 no 1820 0.459025490790153 608 4017482 SGTC_2876 9059903 25.97 µM -0.102911540253091 0.466776067999576 no 1821 0.459016589268284 586 6916095 SGTC_3295 9122362 53.5725 µM -0.103442759987537 0.466531390784054 no 1822 0.458805788293436 606 4730473 SGTC_2540 epiandrosterone 100 µM -0.104355557644875 0.466110990230915 no 1823 0.458443594957315 584 441302 A steroid. SGTC_1374 2889-5571 141 µM -0.104715522028194 0.465945214432476 no 1824 0.458300772441216 585 2853281 SGTC_49 0717-0965 32.132 µM -0.105684462830544 0.465499013792846 no 1825 0.457916354085544 656 5889349 YGL099W LSG1 SGTC_1556 plumbagin 1.48 µM -0.106065096431001 0.465323742518565 no 1826 0.457765351952902 596 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_912 3474-0017 2.18 µM -0.106618997365269 0.465068698442244 no 1827 0.457545623387619 599 3360550 SGTC_313 3474-0040 5.03 µM -0.107299329611844 0.464755458625604 no 1828 0.457275758182738 593 1043375 YIL048W NEO1 SGTC_1301 naphtanilide LB 4.81 µM -0.108213781654254 0.464334459386848 no 1829 0.456913056487634 613 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2478 5763493 32.33 µM -0.108963827050971 0.463989180148185 no 1830 0.456615590642218 587 1365576 YLR208W SEC13 SGTC_1285 0929-0069 65.5 µM -0.109744154303396 0.463629989613055 no 1831 0.456306140904635 598 1206237 SGTC_2358 9037157 4 µM -0.111029269498 0.463038506120991 no 1832 0.455796568259026 589 2388925 SGTC_554 4483-2211 187 µM -0.111878487802555 0.462647692055225 no 1833 0.45545987687437 600 747107 SGTC_2235 salicylic acid 500 µM -0.112312559382867 0.462447944270877 no 1834 0.45528779193165 588 338 A COX inhibitor and kinase inhibitor. SGTC_2857 9024691 58.44 µM -0.112406280610112 0.462404817585042 no 1835 0.455250637841804 635 16478292 SGTC_3109 9122853 49.47 µM -0.112814952867168 0.462216768454168 no 1836 0.455088631676532 634 1234709 SGTC_1360 1598-0022 39.8 µM -0.112821987960914 0.462213531353844 no 1837 0.455085842884666 619 761525 SGTC_397 arbidol 50 µM -0.113018855586641 0.462122946475779 no 1838 0.455007803197538 575 131410 A RNA synthesis inhibitor. SGTC_271 rotenone 740 µM -0.11366270382716 0.461826705748468 no 1839 0.454752589447229 595 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_365 0121-0052 13.6 µM -0.115100119683921 0.461165413633977 no 1840 0.454182882520661 601 3101739 SGTC_2101 5377231 179.231 µM -0.116113082304935 0.460699458256807 no 1841 0.453781460383071 621 2844213 SGTC_393 acivicin 6.25 µM -0.116165120055046 0.460675522725036 no 1842 0.453760839862171 615 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_221 trifluoperazine 10.304 µM -0.118060974807297 0.459803594175233 no 1843 0.453009672365386 593 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_168 3970-0862 530.542 µM -0.119418623057918 0.459179312398878 no 1844 0.452471853901469 593 3135186 SGTC_173 1273-0061 2.693 µM -0.119621404055021 0.459086077053937 no 1845 0.452391531744284 609 2847414 YPL266W DIM1 SGTC_2997 9067075 71.4286 µM -0.120221717835553 0.458810075929005 no 1846 0.452153757101111 610 27209819 SGTC_1267 0828-0272 9.49 µM -0.120263012255795 0.458791091075456 no 1847 0.452137401674562 611 745334 SGTC_2531 methyl deoxycholate 70.07 µM -0.120290198971636 0.4587785922028 no 1848 0.452126633912223 620 16667744 Haematoxylin. SGTC_1246 0422-0085 105 µM -0.120318054912433 0.458765785701653 no 1849 0.452115601128454 613 264295 SGTC_1078 idebenone 36.1 µM -0.120495101104018 0.458684391417036 no 1850 0.452045480062526 594 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2808 7946468 45.46 µM -0.122213924236814 0.457894279262196 no 1851 0.451364799586979 646 2970879 SGTC_2623 humulene 100 µM -0.122304169962102 0.457852799491007 no 1852 0.451329064820708 612 6187145 An anti-inflammatory. SGTC_537 1334-0398 209 µM -0.12380150927869 0.457164642622964 no 1853 0.450736218388859 625 5846986 SGTC_2714 st079313 56.9 µM -0.124383773573855 0.456897076405447 no 1854 0.450505710192438 594 2939799 SGTC_1953 st076800 12.1 µM -0.124387501867009 0.45689536321657 no 1855 0.45050423428044 606 297591 SGTC_118 0083-0097 135.343 µM -0.124952050528075 0.456635956589994 no 1856 0.450280755434818 612 5207356 SGTC_464 bw-b 70c 158 µM -0.125207561721799 0.456518556840683 no 1857 0.450179615484452 635 5353454 SGTC_2588 indole-3-carbinol 100 µM -0.125710505523431 0.456287480308207 no 1858 0.449980542819349 602 3712 Induces cell cycle arrest. SGTC_1640 st009078 66.4 µM -0.125825124763522 0.456234820791184 no 1859 0.449935176572191 612 690618 SGTC_489 paxilline 115 µM -0.125960151209652 0.456172786577811 no 1860 0.449881734000854 645 105008 A toxic potassium channel blocker. SGTC_3228 9131799 49.47 µM -0.126021715869122 0.456144502730714 no 1861 0.449857367418815 598 17015818 SGTC_2254 7938975 95.19 µM -0.127051504946942 0.455671433246985 no 1862 0.449449816879492 650 2969277 SGTC_3076 9116187 49.47 µM -0.127679341138144 0.455383045616046 no 1863 0.449201369824228 641 27241210 SGTC_2118 5526350 200 µM -0.127686048246594 0.455379964927754 no 1864 0.449198715797628 623 743594 SGTC_1797 st048695 56.8 µM -0.12880608938397 0.454865548877784 no 1865 0.448755543520569 607 592262 YIL048W NEO1 SGTC_139 0099-0334 718.624 µM -0.131596162320515 0.453584446232334 no 1866 0.447651860575716 609 97690 SGTC_3243 9134147 49.47 µM -0.132372152001362 0.45322822451406 no 1867 0.44734497015273 611 24282180 SGTC_1614 st002383 48.6 µM -0.133531089188475 0.452696279097121 no 1868 0.446886689401061 617 1947235 SGTC_1105 epirubicin 18.1 µM -0.133593253598832 0.452667748385191 no 1869 0.446862109607755 615 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2768 sulfasalazine 50.2 µM -0.134348085529033 0.452321333492648 no 1870 0.446563665554557 649 5384001 An antioxidant and salicylic acid derivative. SGTC_2205 7238770 200 µM -0.134772407021305 0.45212661561842 no 1871 0.446395911384568 624 279867 SGTC_1903 st060211 78.3 µM -0.135162016117544 0.451947837135203 no 1872 0.446241889098662 597 688960 SGTC_1951 sophoraflavanone G 9.2 µM -0.137018462249279 0.451096111016037 no 1873 0.445508100990165 621 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1530 rhein 70.4 µM -0.13778309060833 0.450745369436008 no 1874 0.445205924313968 597 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1336 1486-0901 104 µM -0.137850100202712 0.450714633389822 no 1875 0.445179444026991 600 5006114 SGTC_2305 7443522 69.23 µM -0.138574671571602 0.450382304984331 no 1876 0.44489312966407 610 5415886 SGTC_2070 5230947 200 µM -0.13898504334547 0.450194101263211 no 1877 0.444730984006858 648 2835538 SGTC_254 nsc-64875 3.808 µM -0.13906524062578 0.450157322685357 no 1878 0.444699297622458 634 56993 SGTC_3235 9132602 49.47 µM -0.139390050185918 0.450008368976377 no 1879 0.444570967203539 623 4912240 SGTC_544 k015-0020 52.4 µM -0.139580321795668 0.449921116002882 no 1880 0.44449579466516 587 3008304 SGTC_1420 4'-methoxyflavone 42 µM -0.139618734817354 0.449903501212582 no 1881 0.444480618684457 607 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1736 st036774 51 µM -0.139699127317742 0.449866636506253 no 1882 0.444448857972558 650 1272247 SGTC_2279 7948423 32.93 µM -0.140031291563288 0.449714324184892 no 1883 0.444317633434622 596 1247112 SGTC_1456 k015-0012 13 µM -0.141744775880083 0.448928732331542 no 1884 0.443640802972444 627 2989616 SGTC_2929 9013348 24.6 µM -0.141866361839455 0.448872995627751 no 1885 0.443592782446003 620 2995952 SGTC_1371 2421-0008 32.7 µM -0.141890425666229 0.448861964552671 no 1886 0.443583278505745 631 2827552 SGTC_3058 9093861 49.47 µM -0.142634659770824 0.448520820490223 no 1887 0.443289361401066 628 17217477 SGTC_2513 baicalein 25.65 µM -0.142794450547948 0.448447580111946 no 1888 0.443226259994512 643 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1483 3453-0561 55.9 µM -0.143344282634839 0.448195577066691 no 1889 0.443009142215292 613 4546991 SGTC_1717 st033143 58.0435 µM -0.143535138121943 0.44810810767258 no 1890 0.442933781168577 632 674616 SGTC_1559 coumarin 343 70.1 µM -0.143678822850986 0.448042258381484 no 1891 0.442877047292088 632 108770 A hepatotoxic, DNA x-linker. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.143772122682695 0.447999500757377 no 1892 0.442840208505822 685 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_655 k060-0012 42 µM -0.145223529725751 0.447334425290649 no 1893 0.442267194414045 622 5994525 SGTC_907 3448-6986 75.5 µM -0.147480975433483 0.446300295172768 no 1894 0.441376197464921 628 590582 SGTC_2274 7947094 46.08 µM -0.147553828720304 0.446266927312331 no 1895 0.441347447733541 611 2971028 SGTC_843 0310-0051 143 µM -0.148498885139653 0.445834112352389 no 1896 0.440974532865436 615 2065037 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.148919048819074 0.44564170736484 no 1897 0.440808755017035 639 6728940 SGTC_2657 nystatin 74.44 µM -0.14906353049219 0.445575548022561 no 1898 0.440751751387971 619 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2094 5332512 191.667 µM -0.149260667476422 0.445485279826794 no 1899 0.440673975175055 621 755774 SGTC_567 1080-0542 68.4 µM -0.150279702724965 0.445018713037274 no 1900 0.440271973001982 606 5950415 SGTC_1789 tunicamycin 25 nM -0.150466621439925 0.444933140274778 no 1901 0.440198241564791 619 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1066 ketoconazole 628 nM -0.150829896445677 0.44476683764876 no 1902 0.440054951048549 616 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_895 0964-0006 13.7 µM -0.152077106615022 0.444195955033258 no 1903 0.439563060222618 633 6738897 SGTC_3010 9080089 71.4286 µM -0.154146849910943 0.443248832251332 no 1904 0.438746974403045 628 17027233 SGTC_2433 5607874 27.82 µM -0.154982985041997 0.442866305101401 no 1905 0.438417365594859 601 2252428 SGTC_274 sirtinol 40.1 µM -0.155232067897775 0.442752361365083 no 1906 0.438319184086949 614 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1980 st071811 45.7 µM -0.1554378690144 0.442658220568326 no 1907 0.438238065896053 655 4974850 SGTC_2081 5214970 32.255 µM -0.157944199752896 0.441511996547222 no 1908 0.437250384396647 626 2063512 SGTC_2750 bromebric acid 70.15 µM -0.158634531969934 0.441196371474179 no 1909 0.436978410350966 638 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_638 3970-0837 4.09 µM -0.159119132176159 0.440974830917481 no 1910 0.436787507480461 616 4118451 YLR208W SEC13 SGTC_751 0833-0568 350 µM -0.161299724650921 0.439978177525585 no 1911 0.435928670058683 607 6954252 SGTC_2583 asiatic acid 100 µM -0.162306816593106 0.439518007840295 no 1912 0.435532123496148 620 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2131 toluylene red 5.2905 µM -0.162616097801807 0.439376704605512 no 1913 0.435410355748334 609 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2232 chlorophetanol 41.5365 µM -0.163593659893541 0.438930130588399 no 1914 0.435025518067146 625 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1554 st069299 38.7 µM -0.164191982243727 0.438656840769586 no 1915 0.434790006346897 612 24207999 SGTC_583 1488-1091 88.9 µM -0.164967924456922 0.438302464846213 no 1916 0.434484614342482 642 4303273 SGTC_817 1391-0715 46 µM -0.165091653005695 0.438245962086653 no 1917 0.434435921400369 615 1353946 SGTC_609 0986-0026 86.3 µM -0.165150587299233 0.438219049175311 no 1918 0.434412728362797 628 2848610 SGTC_1289 0976-0073 69.1 µM -0.166073225887183 0.437797754728891 no 1919 0.434049662094111 642 3391136 SGTC_233 rapamycin 362 pM -0.16629965064136 0.437694375605785 no 1920 0.433960570483132 612 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3212 9128307 49.47 µM -0.169395959556627 0.436281118394064 no 1921 0.432742600693977 667 27243542 SGTC_1162 k048-0130 20.1 µM -0.170569657190614 0.435745615735786 no 1922 0.43228107914383 646 6797406 SGTC_1054 3429-0080 167 µM -0.171925270913054 0.435127260023213 no 1923 0.431748139537946 667 1162877 SGTC_1212 0520-0165 585 µM -0.174666778359618 0.433877222812031 no 1924 0.430670736728306 712 5403258 SGTC_514 4466-0038 2.65 nM -0.175225002834894 0.433622771409361 no 1925 0.43045141941753 646 5722064 SGTC_3120 9124077 49.47 µM -0.175654726442327 0.433426912355317 no 1926 0.430282602615569 632 18774327 YGL155W CDC43 SGTC_479 n-linoleoylglycine 10 µM -0.176418513097302 0.433078834715597 no 1927 0.429982580707092 639 6433346 An anti-infammatory. SGTC_2904 7225135 42.03 µM -0.176784946610703 0.432911859748961 no 1928 0.429838656838245 634 4446116 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.17688410030766 0.432866679844257 no 1929 0.429799713902725 619 5106787 A p450 inhibitor. SGTC_2905 7799065 20.05 µM -0.176921863351543 0.432849473144968 no 1930 0.429784882524547 670 1296806 SGTC_2508 celastrol 40.54 µM -0.177573680548961 0.432552493277982 no 1931 0.429528897943117 613 122724 Celastrol is a natural product and antioxidant. SGTC_3205 9113483 49.47 µM -0.179209357689482 0.431807416898475 no 1932 0.428886658150543 671 17018033 SGTC_3249 9135183 49.47 µM -0.179357092675393 0.431740133216293 no 1933 0.428828660049961 655 4902779 SGTC_1009 4106-0057 9.87 µM -0.180459818463354 0.431237975988734 no 1934 0.428395798351337 618 2928005 SGTC_2363 9053361 176 µM -0.181066975184629 0.430961537469179 no 1935 0.428157503042784 652 6469797 YMR079W SEC14 SGTC_686 1319-0111 510 µM -0.182550026508025 0.430286446507148 no 1936 0.427575549185222 661 4562600 SGTC_2163 5671233 125 µM -0.183332628266458 0.429930285010878 no 1937 0.42726851729038 603 701023 SGTC_2976 9009005 19.48 µM -0.183569141667406 0.429822659137745 no 1938 0.427175736536857 616 2993148 SGTC_2925 9010536 32.5 µM -0.184001549328114 0.429625904696851 no 1939 0.427006119743655 627 2994177 SGTC_2882 9058044 58.44 µM -0.184410736925974 0.429439731960422 no 1940 0.426845623709358 647 18076804 SGTC_2765 myclobutanil 7.74 µM -0.186178281539383 0.428635712889812 no 1941 0.426152477503687 652 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1074 carmofur 3.8 µM -0.186240285411265 0.428607513981548 no 1942 0.426128166687769 633 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1325 1431-0015 227 µM -0.188588677165669 0.427539752148269 no 1943 0.425207603941097 629 1103340 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.188831806270216 0.427429236890025 no 1944 0.425112321239071 622 1273210 SGTC_1250 0485-0349 40.2 µM -0.189877057672681 0.426954178864259 no 1945 0.424702735365639 658 6842794 YDL195W SEC31 SGTC_138 0850-0259 40.9225 µM -0.18996572114191 0.426913886922585 no 1946 0.424667995970224 640 6813004 SGTC_1910 st062352 60.4 µM -0.190128608628108 0.42683986684504 no 1947 0.424604176252552 618 2245730 SGTC_1844 rapamycin 4 nM -0.190585139316177 0.426632421815579 no 1948 0.424425316943981 645 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_227 fluconazole 33.516 µM -0.190609606696169 0.426621304545349 no 1949 0.424415731568122 642 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2779 methotrexate 400 µM -0.191559610666616 0.42618969536041 no 1950 0.42404359126923 639 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_699 0375-0592 111 µM -0.191572248673761 0.426183954210666 no 1951 0.424038641101663 611 762578 SGTC_3237 9133362 49.47 µM -0.191815462275954 0.426073471033827 no 1952 0.423943379360244 669 43845137 SGTC_2911 7942208 15.64 µM -0.192180069250446 0.425907854093382 no 1953 0.423800578670269 630 1243384 SGTC_2222 6885208 172.143 µM -0.192686794929955 0.425677703691498 no 1954 0.4236021328862 615 609514 SGTC_1928 4'-methoxychalcone 40.3 µM -0.193364114811431 0.425370110437044 no 1955 0.423336908636059 663 641818 SGTC_651 3253-0966 34.4 µM -0.193757314425724 0.425191566373166 no 1956 0.423182955846701 631 781462 SGTC_2734 clemastine 41.6 µM -0.194170199143239 0.425004100212366 no 1957 0.423021308205809 652 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2731 amoxapine 43.43 µM -0.194325417843614 0.424933629103435 no 1958 0.422960542203935 622 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.194802596942782 0.424716999232918 no 1959 0.422773744586413 662 7104 SGTC_2106 5357045 167.29 µM -0.19491865203537 0.424664315951593 no 1960 0.422728316018822 640 668842 SGTC_2966 9084041 48.03 µM -0.195016941241644 0.424619698557842 no 1961 0.422689842527666 640 17741380 SGTC_3189 9110682 49.47 µM -0.195627924592555 0.424342370512119 no 1962 0.422450700953923 653 17122418 SGTC_726 3448-4391 34.2 µM -0.197339124127919 0.423565849245097 no 1963 0.421781082319438 666 1356692 SGTC_1211 1056-0033 32.3 µM -0.197475884232808 0.423503801960585 no 1964 0.421727575723417 631 6741922 SGTC_2511 berberine 10.47 µM -0.199652065942689 0.422516736886278 no 1965 0.420876352363247 636 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1626 st003712 1.76 µM -0.20026761705547 0.422237625285601 no 1966 0.420635643668376 670 24207035 SGTC_2712 st079126 47.7 µM -0.200860680405929 0.421968747324587 no 1967 0.420403756783495 651 3152970 SGTC_265 mycophenolic acid 32.932 µM -0.200998233806487 0.421906389738123 no 1968 0.420349977552477 649 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3093 9117344 49.47 µM -0.202180938844888 0.421370310683295 no 1969 0.419887637007655 631 24824913 SGTC_1710 st031758 61.5 µM -0.202420212033638 0.421261874159827 no 1970 0.419794114264276 625 5394341 SGTC_1553 gossypol 38.6 µM -0.20382053462884 0.420627380170788 no 1971 0.419246872679148 627 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2357 9067248 200 µM -0.205036441867428 0.420076612962537 no 1972 0.418771826660871 665 9150235 SGTC_2881 9058953 51.95 µM -0.206108105795785 0.419591313069804 no 1973 0.418353233599576 614 17122249 SGTC_502 l-744,832 89.3 µM -0.20815377933618 0.418665275815857 no 1974 0.417554448410357 657 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1719 st032227 49.2 µM -0.208227224697971 0.418632036854178 no 1975 0.417525776108152 626 3125804 SGTC_1550 gossypolone 36.6 µM -0.20831506868971 0.418592282307821 no 1976 0.417491483307067 635 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2354 9060492 162 µM -0.208387834648887 0.41855935208307 no 1977 0.417463077188769 664 6471895 SGTC_3167 9103034 49.47 µM -0.20892270905422 0.418317312275869 no 1978 0.417254288035418 625 5127859 SGTC_1965 Pectolinarigenin 58.4 µM -0.210170056442266 0.417752986580189 no 1979 0.416767474557516 639 5320438 An anti-inflammatory. SGTC_2073 5212005 126 µM -0.210282848930278 0.41770196526206 no 1980 0.41672346029952 644 691789 SGTC_1606 st000094 49.2 µM -0.21057025471357 0.417571964447256 no 1981 0.416611312583776 650 1242210 SGTC_2906 7926292 26.41 µM -0.2108054595828 0.417465582111887 no 1982 0.416519539073552 682 2966319 SGTC_2864 9034755 47.6 µM -0.21111674441346 0.417324798366448 no 1983 0.416398087268614 624 4930451 SGTC_3032 9089427 49.47 µM -0.211358107522521 0.417215645177122 no 1984 0.41630392182105 628 17173707 SGTC_2852 9023854 51.95 µM -0.21150761036323 0.417148037746334 no 1985 0.416245597164285 659 19798528 SGTC_2253 7938677 135.83 µM -0.211895024692966 0.416972854569589 no 1986 0.41609446609381 647 2301972 SGTC_2799 7812892 81.82 µM -0.211937470672584 0.416953662110642 no 1987 0.416077908589721 640 20205235 SGTC_188 3229-0966 278.469 µM -0.212085496830059 0.416886731856445 no 1988 0.416020167096839 638 5722370 SGTC_1064 honokiol 6.76 µM -0.212092929918361 0.416883371037668 no 1989 0.416017267673191 650 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2822 7994718 71.43 µM -0.212706132352371 0.416606136797956 no 1990 0.415778091648036 638 1018011 SGTC_3085 9117376 49.47 µM -0.212989962715862 0.416477828615239 no 1991 0.415667395829511 642 16480349 SGTC_2894 9048625 32.47 µM -0.214170402578239 0.415944295299376 no 1992 0.41520708794631 636 4092861 SGTC_2686 alizarin 95.37 µM -0.214507378051858 0.415792018039824 no 1993 0.415075707007729 641 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_693 4161-2696 114 µM -0.215155248044652 0.415499284892432 no 1994 0.414823140338251 634 805759 SGTC_688 0527-0193 473 µM -0.216319532671649 0.414973333257742 no 1995 0.414369342310866 639 4007154 SGTC_2239 6685329 187.64 µM -0.217884989824337 0.414266397042404 no 1996 0.413759361289456 649 805680 SGTC_1558 st069300 45.6 µM -0.218182179671039 0.414132221998516 no 1997 0.413643584594734 639 24208000 SGTC_1451 4152-0210 104 µM -0.218296242991972 0.414080727438393 no 1998 0.413599150768541 691 659563 SGTC_2661 dactinomycin 12.96 µM -0.219768269717724 0.413416305117 no 1999 0.413025816294133 631 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2272 7805186 180 µM -0.219900336336527 0.413356706868263 no 2000 0.412974387182367 700 2956062 YPR165W RHO1 SGTC_2663 amphotericin b 100 µM -0.220475185360809 0.413097315647341 no 2001 0.412750548064828 661 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_684 1140-0066 328 µM -0.221788846386826 0.412504690157782 no 2002 0.412239131267096 668 6813534 SGTC_1124 fisetin 1.16336 µM -0.222463283415285 0.412200512054218 no 2003 0.41197662636267 672 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_357 1325-0123 420 µM -0.222701906979261 0.412092902969535 no 2004 0.411883758539793 692 1098503 SGTC_1723 st034307 2.5525 µM -0.223002863470308 0.411957193809629 no 2005 0.411766638946611 631 867466 SGTC_1421 4029-0249 71.4 µM -0.223189635973442 0.411872978492487 no 2006 0.411693958905254 665 2894095 SGTC_2718 lomofungin 53.02 µM -0.22328301023856 0.411830877760149 no 2007 0.411657624684718 663 5351222 A RNA synthesis inhibitor. SGTC_2896 9052656 71.43 µM -0.22338723835127 0.411783884427062 no 2008 0.411617067860165 663 6469436 SGTC_3181 9108277 49.47 µM -0.223519815480045 0.411724111200349 no 2009 0.411565481344873 673 17097298 SGTC_2284 7945075 39.21 µM -0.225451807776727 0.410853293520091 no 2010 0.410813906042572 656 1245402 SGTC_293 4049-0273 38.5 µM -0.225463857092644 0.410847863838281 no 2011 0.410809219693932 639 1380311 SGTC_3346 9158254 43.5805 µM -0.22582560338265 0.410684861111954 no 2012 0.410668531394742 646 17639500 SGTC_2634 4'-methoxyflavone 100 µM -0.226128821642561 0.41054824297301 no 2013 0.410550614335587 667 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1941 st076221 61.8 µM -0.226344203707883 0.410451206936086 no 2014 0.410466860372989 622 2828568 SGTC_406 estrone 100 µM -0.226585642959511 0.410342437877195 no 2015 0.410372978607263 670 5870 A steroid. SGTC_2930 9013230 14.89 µM -0.226814421352156 0.41023937893387 no 2016 0.410284024656405 648 2995857 SGTC_2709 st078560 56 µM -0.227202621313566 0.41006451874834 no 2017 0.410133094740229 665 17250903 SGTC_978 1416-0512 87.4 µM -0.227415212628859 0.409968767023121 no 2018 0.410050446097004 654 6814003 SGTC_83 0170-0301 39.027 µM -0.22815461183977 0.409635781382532 no 2019 0.409763022682224 630 3089716 SGTC_1818 st052136 56.3 µM -0.228912716283347 0.409294439576373 no 2020 0.409468378404412 642 674169 SGTC_1860 st056228 74.6 µM -0.229713326127265 0.408934034071426 no 2021 0.409157269522723 692 688679 SGTC_916 4466-0038 42 nM -0.229868695895237 0.408864101148568 no 2022 0.409096901026256 659 5722064 YGL116W CDC20 SGTC_3126 9127922 49.47 µM -0.231115135187406 0.408303176057276 no 2023 0.408612678607966 696 45595682 SGTC_2766 oltipraz 83.91 µM -0.234454566809997 0.406801287159825 no 2024 0.407316050342088 655 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1624 st003710 6.25 µM -0.234470447085878 0.406794148357941 no 2025 0.407309886791771 689 24207033 SGTC_81 0411-0046 9.971 µM -0.234475544998683 0.40679185665435 no 2026 0.407307908163374 661 12925265 SGTC_650 1328-0195 38 µM -0.235017400049712 0.406548290638499 no 2027 0.407097614061892 658 2780821 SGTC_453 enantio-paf c16 10 µM -0.235111059032305 0.40650619421238 no 2028 0.407061267696442 682 13871343 A lipid and platelet activating factor SGTC_3291 9121177 71.43 µM -0.236261220170609 0.405989325391827 no 2029 0.406614988495006 666 17015612 SGTC_1441 4106-0040 13 µM -0.236339027739315 0.405954365496168 no 2030 0.406584802402573 641 2904180 SGTC_1568 digitonin 820 nM -0.236486768163581 0.40588798597427 no 2031 0.406527486805863 681 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_483 fpl-64176 144 µM -0.236833289379936 0.405732305198469 no 2032 0.406393062464277 650 3423 SGTC_1964 st076914 61 µM -0.238311950508884 0.405068158402215 no 2033 0.405819576581315 675 24208661 SGTC_1525 8-methoxypsoralen 92.5 µM -0.238639821517802 0.404920930728784 no 2034 0.405692441983061 713 4114 Related to psoralen; DNA damaging agent. SGTC_2519 cryptotanshinone 88.04 µM -0.241099705191254 0.403816771604358 no 2035 0.404738920631055 643 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_576 1073-0113 22.7 µM -0.241156003599709 0.403791510073737 no 2036 0.404717104352555 666 5439563 SGTC_1955 wogonin 32.4 µM -0.242471906470343 0.403201168817999 no 2037 0.404207261417864 645 5281703 A flavanone. SGTC_25 0118-0223 35.662 µM -0.244024559540033 0.402504900236401 no 2038 0.40360589951242 652 5333628 SGTC_106 0092-0003 11.579 µM -0.247040120167647 0.401153493520274 no 2039 0.402438587354766 659 1072148 SGTC_187 1488-2104 32.728 µM -0.247542723657398 0.400928369024021 no 2040 0.402244115683833 646 2852859 SGTC_1841 st054148 70 µM -0.248591264472426 0.400458816062716 no 2041 0.401838483181233 691 675442 SGTC_1365 1672-3266 55.4 µM -0.248959729409141 0.400293845822026 no 2042 0.401695966024118 655 6415873 SGTC_675 1309-0189 238 µM -0.249527260194998 0.400039784023027 no 2043 0.401476478522546 643 4246530 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.249618074644209 0.399999133795325 no 2044 0.401441359722057 665 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3285 9112818 20.8695 µM -0.250406616538071 0.399646213451926 no 2045 0.40113645666142 664 17017947 YPR165W RHO1 SGTC_2471 5466956 24.79 µM -0.250428791731814 0.399636289890932 no 2046 0.401127883117112 651 724419 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.251220289453341 0.399282131386687 no 2047 0.400821899375702 657 4330530 SGTC_2560 caryophyllene 100 µM -0.251361607311785 0.39921890691355 no 2048 0.40076727394358 652 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2146 5545642 200 µM -0.251759822099986 0.399040763045084 no 2049 0.400613357236562 660 825326 SGTC_1084 voriconazole 435 nM -0.25209696400312 0.398889956946959 no 2050 0.40048305828679 660 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3101 9120531 49.47 µM -0.25319831022913 0.39839742182447 no 2051 0.400057486111816 716 24824904 SGTC_1382 3002-2117 298 µM -0.2532880463512 0.39835729788293 no 2052 0.400022816318456 671 1497314 SGTC_1943 st076331 65.2 µM -0.254590510187711 0.397775045094175 no 2053 0.399519694748479 662 24208415 SGTC_1155 4088-0394 48.2 µM -0.254736232731681 0.397709915495317 no 2054 0.399463414751447 655 2326248 SGTC_1811 st050069 61.5 µM -0.254804004946233 0.397679626183151 no 2055 0.399437240926699 661 3877702 SGTC_2218 6965428 192.983 µM -0.254977181779049 0.397602231379581 no 2056 0.39937036158767 650 675684 SGTC_3273 9137859 49.47 µM -0.255194825542314 0.397504969487535 no 2057 0.399286313707117 648 2377234 SGTC_3343 9148379 18.9835 µM -0.255350563096476 0.397435376507579 no 2058 0.399226175122829 662 1955036 SGTC_35 0133-0054 64.071 µM -0.255420404963134 0.397404167987957 no 2059 0.399199206225999 679 99677 SGTC_1978 st071761 42 µM -0.255478824243103 0.397378064103525 no 2060 0.399176648442207 647 5147680 SGTC_2760 etidronate 98.04 µM -0.255838508158778 0.397217354222355 no 2061 0.399037768974422 639 3305 A chelator and antioxidant. SGTC_1305 1181-0477 144 µM -0.256248528059584 0.397034175072374 no 2062 0.398879469599887 655 6252086 SGTC_760 0568-0725 82.9 µM -0.257210145477889 0.396604655187268 no 2063 0.398508276232723 682 3916171 SGTC_1270 0831-1170 17.3 µM -0.258305531844091 0.396115538370166 no 2064 0.398085558653653 656 6764716 SGTC_721 1187-1332 279 µM -0.258490734851372 0.396032856832706 no 2065 0.398014099269971 679 25730 SGTC_1237 0330-0133 46.1 µM -0.259530084251623 0.395568939326956 no 2066 0.397613136552789 694 X1237 YHR072W ERG7 SGTC_1751 st044839 27.194 µM -0.26015888529149 0.395288343400389 no 2067 0.397370608649675 638 5291326 SGTC_921 1561-0023 372 µM -0.260438488199539 0.395163590936016 no 2068 0.397262778837433 660 24050882 SGTC_3257 9139206 32.98 µM -0.261602038312393 0.394644556845227 no 2069 0.396814136193364 678 4910041 SGTC_955 1216-0110 33 µM -0.262440937917215 0.394270458131973 no 2070 0.396490757245692 645 3619719 SGTC_600 1495-0418 41.6 µM -0.262935250870479 0.394050069951665 no 2071 0.396300242848963 666 5377768 SGTC_107 0358-0022 2.6945 µM -0.263346539614796 0.393866723756341 no 2072 0.396141745890503 700 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2893 9048488 25.97 µM -0.26636854872854 0.392520282471739 no 2073 0.394977692480361 653 6467338 SGTC_1145 3546-0597 10.2 µM -0.266583689778989 0.392424476260983 no 2074 0.394894857489624 658 875334 SGTC_288 1315-0019 35.1 µM -0.266952466415445 0.392260268506057 no 2075 0.394752879790437 666 6811474 SGTC_2195 6536160 144.242 µM -0.267111299848582 0.392189549539894 no 2076 0.394691733786266 657 3834386 SGTC_128 0906-2981 13.371 µM -0.267214661757833 0.392143530616392 no 2077 0.394651944012093 689 6740226 SGTC_177 1327-0068 8.361 µM -0.26848820846646 0.391576644485758 no 2078 0.394161775036635 646 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2326 6164455 177.58 µM -0.268892137305771 0.391396894109715 no 2079 0.394006343869566 673 2888790 SGTC_1754 st042065 16.137 µM -0.269202142074492 0.391258956145939 no 2080 0.393887065981845 655 1126236 YIL048W NEO1 SGTC_178 4092-0806 87.505 µM -0.269560663054144 0.391099447738032 no 2081 0.393749133338986 638 2169044 SGTC_2989 9073649 71.4286 µM -0.271278537719522 0.390335408267835 no 2082 0.393088406091328 701 21367202 SGTC_1727 st034309 9.9045 µM -0.272703614233464 0.389701914394999 no 2083 0.392540528109648 700 870305 SGTC_2345 9052315 157.45 µM -0.27460065917872 0.388859069609476 no 2084 0.391811529922985 651 6469265 SGTC_2397 5161689 200 µM -0.275510650285618 0.388454951755739 no 2085 0.391461972287972 692 2259942 SGTC_3315 9136395 68.55 µM -0.276118591962415 0.388185038233313 no 2086 0.391228490623099 729 16876844 SGTC_181 1447-1644 8.07 µM -0.276805016128111 0.387880345019892 no 2087 0.390964914652973 700 534600 SGTC_3169 9102970 49.47 µM -0.276921961589931 0.38782844158961 no 2088 0.390920014443575 640 17027839 SGTC_2705 st078069 42.8 µM -0.27725296504926 0.38768154453275 no 2089 0.390792936381723 687 1530061 SGTC_2499 avocadenofuran 51.48 µM -0.277458252003769 0.387590447670596 no 2090 0.390714128959992 703 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.277640254640629 0.387509688487226 no 2091 0.390644263887458 659 16725076 SGTC_2281 7943571 200 µM -0.278380458605196 0.387181291409724 no 2092 0.390360159326569 683 1244024 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.278791555875647 0.386998939854708 no 2093 0.390202397537247 661 140250 A respiratory chain inhibitor. SGTC_2353 9059630 146.67 µM -0.279270209011702 0.386786653781759 no 2094 0.39001873343931 673 4779114 SGTC_1050 3232-1156 69.3 µM -0.279479454712458 0.386693862459317 no 2095 0.389938451435815 680 700529 SGTC_1947 st076332 61.6 µM -0.279705024129418 0.386593839537286 no 2096 0.389851911715582 691 24208416 SGTC_2066 5222451 176 µM -0.280386649516998 0.38629163619759 no 2097 0.389590439288794 686 2281147 SGTC_1625 st003711 30.1 µM -0.280601013348556 0.38619661075354 no 2098 0.389508219353937 664 24207034 YER133W GLC7 SGTC_1108 betulinic acid 729.144 nM -0.281061804312105 0.385992369624023 no 2099 0.389331498247971 652 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2855 9016525 58.44 µM -0.28372191884298 0.384813918959316 no 2100 0.388311747949088 669 43811474 SGTC_1043 0916-0009 19.3 µM -0.288052768951717 0.382897599002482 no 2101 0.386653172923883 719 3101130 SGTC_1806 st050005 60.3 µM -0.289439331274681 0.382284673925115 no 2102 0.386122600182848 671 5194765 SGTC_2723 salbutamol 83.58 µM -0.292417290000715 0.380969275974729 no 2103 0.384983795074507 699 9884233 β2-adrenoceptor agonist SGTC_2695 st077686 51.995 µM -0.292927271286438 0.380744148907721 no 2104 0.384788871617108 668 2876092 SGTC_664 1222-0054 14.9 µM -0.293344494732279 0.380559999051689 no 2105 0.384629423424721 669 6813991 SGTC_607 4491-0986 66.8 µM -0.293436976857179 0.380519183891159 no 2106 0.384594082635953 682 698981 YDR232W HEM1 SGTC_1839 st053978 48 µM -0.294252739984043 0.380159220589288 no 2107 0.384282391400399 666 3788398 SGTC_3289 9119912 71.43 µM -0.295393547618214 0.379656002378479 no 2108 0.383846630885012 733 17014829 SGTC_981 1488-1094 54.9 µM -0.295945245956121 0.379412717430743 no 2109 0.383635948299509 649 3449522 SGTC_989 1501-0895 10.3 µM -0.297401465795774 0.378770791027941 no 2110 0.38308001237034 685 2830112 SGTC_2928 9011484 9.79 µM -0.297469399978373 0.378740852635715 no 2111 0.383054083244628 693 2994751 SGTC_2359 9039622 200 µM -0.298425905912172 0.37831940063829 no 2112 0.382689059639662 668 6463596 SGTC_739 1486-1183 203 µM -0.29892420492284 0.378099899330851 no 2113 0.382498939082394 683 4346692 SGTC_2689 tacrolimus 100 µM -0.299273011328597 0.377946273097503 no 2114 0.382365872645305 689 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2702 st077768 96.8 µM -0.300045286140714 0.377606205640778 no 2115 0.3820713063461 660 6484119 SGTC_1603 st002045 67.8 µM -0.302738200882759 0.376421137357165 no 2116 0.381044691477086 688 5887985 SGTC_1511 0906-3109 28.5 µM -0.303156349928245 0.37623722704329 no 2117 0.380885356163604 671 2882180 SGTC_1914 st062367 72.6 µM -0.3033602996289 0.37614753607747 no 2118 0.380807648641873 694 978205 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.303426457455487 0.37611844328468 no 2119 0.380782442671276 668 5355888 SGTC_2405 ticlatone 3.52 µM -0.30385075838348 0.375931874408454 no 2120 0.380620797085388 692 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1652 st011932 78 µM -0.304371027678143 0.375703146971573 no 2121 0.380422618951804 686 1551076 SGTC_724 3910-0327 137 µM -0.304650938093879 0.375580107240747 no 2122 0.380316009987334 721 2885483 SGTC_2245 6637752 200 µM -0.304675211786431 0.375569437892283 no 2123 0.380306765339005 667 681890 SGTC_2726 cimetidine 79.27 µM -0.304859156805657 0.375488589112619 no 2124 0.380236712006029 691 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3206 9114350 49.47 µM -0.304918407410221 0.375462548043618 no 2125 0.380214147934961 695 17087243 SGTC_1820 st053765 18.6 µM -0.30507353377838 0.375394371571322 no 2126 0.380155073972606 676 3690829 SGTC_1767 st044992 70.3 µM -0.306926144130651 0.374580469338588 no 2127 0.379449794378743 689 9600693 SGTC_2360 9040895 200 µM -0.309429741971252 0.373481458372171 no 2128 0.378497324464244 682 4914414 SGTC_2721 ifenprodil 61.44 µM -0.309753793213046 0.373339283710803 no 2129 0.378374096058759 673 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.311992992883782 0.372357326506201 no 2130 0.377522924303332 703 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_587 k089-0003 57 µM -0.312437400261696 0.372162538768355 no 2131 0.377354065318982 667 9659696 SGTC_1531 st059297 52.4 µM -0.31400113497646 0.371477400144059 no 2132 0.376760088373017 674 7566702 SGTC_1526 st051518 75 µM -0.314448198263783 0.371281597437131 no 2133 0.376590327120042 679 673993 SGTC_1753 st043925 64 µM -0.31445583616495 0.371278252513837 no 2134 0.376587427022765 705 670181 SGTC_2620 irigenin 100 µM -0.314593203696095 0.371218095781627 no 2135 0.376535270008603 656 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1342 1486-1464 234 µM -0.31537076703488 0.370877640387265 no 2136 0.376240079858898 689 3253938 SGTC_3241 9133421 49.47 µM -0.316000082604856 0.370602169122135 no 2137 0.376001222717094 688 17018221 SGTC_6 0844-0013 19.835 µM -0.316607959535787 0.370336145198041 no 2138 0.375770547719897 688 1584900 SGTC_334 1502-1024 68.5 µM -0.318666674065509 0.369435655470506 no 2139 0.374989644184643 709 3296216 SGTC_40 0327-0103 19.753 µM -0.319026182227692 0.369278478479166 no 2140 0.374853329397737 674 409036 SGTC_1646 st011709 75.6 µM -0.320026527909807 0.368841242341985 no 2141 0.374474110431747 666 5757843 SGTC_1401 3807-4679 7.6 µM -0.320639688252362 0.368573322975706 no 2142 0.374241728732605 669 3291456 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.321052293200919 0.368393071891867 no 2143 0.374085381250475 678 16623 A steroid. SGTC_1007 4101-0031 70 µM -0.321195642371797 0.368330454980763 no 2144 0.374031067111839 716 1146276 SGTC_1808 st050063 61.5 µM -0.32278214613605 0.367637681944488 no 2145 0.373430117594953 724 4011993 SGTC_1989 st071868 50.2 µM -0.323689628626829 0.36724160812858 no 2146 0.373086511822921 705 16414057 SGTC_689 0833-0039 98 µM -0.323873030958001 0.367161578699333 no 2147 0.373017081301456 730 5374726 SGTC_1677 st019204 53.9 µM -0.323939611739721 0.367132526941431 no 2148 0.37299187687109 693 3945625 SGTC_1426 4048-4480 71.7 µM -0.324543389603928 0.366869110165976 no 2149 0.372763339091596 693 14224343 SGTC_1990 st072050 59.8 µM -0.32477604441451 0.366767624027518 no 2150 0.372675288165365 675 17233948 SGTC_2964 9083345 53.42 µM -0.327224405819129 0.365700192473114 no 2151 0.371749081458285 661 17741579 SGTC_1352 1496-0991 99 µM -0.327425075692252 0.365612750795746 no 2152 0.371673201555957 721 3000039 SGTC_1843 st055809 45.5 µM -0.328524684052248 0.365133721737485 no 2153 0.371257491922544 692 16413835 SGTC_2036 5160441 105 µM -0.329187195866722 0.364845209205837 no 2154 0.371007100163697 678 134534 YIL048W NEO1 SGTC_2179 6298986 200 µM -0.32922127026742 0.364830372456272 no 2155 0.370994223455118 688 738374 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.329285574014185 0.364802373730625 no 2156 0.370969923476796 685 16486 A toxic proline analog. SGTC_640 3381-0960 37.1 µM -0.329691312241429 0.36462572642257 no 2157 0.370816609441708 694 1745025 SGTC_414 piperonyl butoxide 100 µM -0.329847450416677 0.364557755794738 no 2158 0.370757615845601 695 5794 A potent inhibitor of cytochrome P450. SGTC_1502 4534-4282 27.7 µM -0.330620694645348 0.364221207152208 no 2159 0.370465506231941 719 3278949 SGTC_451 chloral hydrate 100 µM -0.331347681677174 0.363904887057841 no 2160 0.370190939366777 712 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_677 0929-0063 136 µM -0.333513424167074 0.362963098845357 no 2161 0.369373378961902 688 1539583 SGTC_1669 st015249 58.4 µM -0.333534006464428 0.362954152453741 no 2162 0.369365612041144 699 722793 SGTC_1437 4092-1038 11.6 µM -0.334841109042278 0.36238615489822 no 2163 0.368872474099372 692 3977136 SGTC_2645 abamectin 100 µM -0.338112390324563 0.360965958899048 no 2164 0.367639246857152 685 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3278 9139605 49.47 µM -0.338804318255296 0.360665809567612 no 2165 0.367378573993762 718 7958859 SGTC_2071 5230951 39.92 µM -0.339200994471638 0.36049377527553 no 2166 0.367229160075048 676 1799272 SGTC_1529 apigenin 74 µM -0.342032458148437 0.359266621275715 no 2167 0.366163232830398 733 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2120 5538279 151.968 µM -0.342570156197737 0.359033746871007 no 2168 0.365960928425169 691 2058197 SGTC_154 3389-1638 511.116 µM -0.3426743540723 0.358988625334716 no 2169 0.365921729152471 746 5238686 SGTC_1692 fluoroquinolonic acid 71 µM -0.342733852529166 0.358962861183078 no 2170 0.365899346442319 723 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1197 1601-0112 267 µM -0.343520614574696 0.358622236136678 no 2171 0.365603417566469 697 7350313 SGTC_1175 0741-0056 27.6 µM -0.344235668284205 0.358312754402439 no 2172 0.365334530082202 702 765927 SGTC_2863 9028737 58.44 µM -0.344290180169951 0.358289164978459 no 2173 0.365314034246046 709 6460917 SGTC_856 0433-0016 11.3 µM -0.344976406393932 0.357992254351529 no 2174 0.365056054070755 699 3911780 SGTC_2399 5884133 200 µM -0.345249557059916 0.357874093689208 no 2175 0.364953382679498 716 722445 SGTC_2844 9010103 25.97 µM -0.348968296617995 0.356266784555814 no 2176 0.363556555395875 750 2480525 SGTC_34 0469-0683 81.75 µM -0.348981465656158 0.356261097165107 no 2177 0.363551612070717 681 3690923 SGTC_2258 7960471 200 µM -0.349872796648161 0.355876227136589 no 2178 0.36321708171668 733 2974708 SGTC_1748 st037455 53.6035 µM -0.350003439106903 0.355819829033264 no 2179 0.36316805833349 724 580690 SGTC_2490 carminic acid 95.39 µM -0.350630164614474 0.355549316710136 no 2180 0.36293291172644 712 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_354 2783-3500 4.88 µM -0.351107410389695 0.355343372815789 no 2181 0.362753884371389 703 6740761 SGTC_197 4544-0043 41.561 µM -0.351135699589337 0.355331166619966 no 2182 0.362743273295112 695 896523 SGTC_2031 5180455 200 µM -0.351338199749099 0.355243796385857 no 2183 0.362667320012912 686 29949 SGTC_2484 5809818 12.04 µM -0.351972270183666 0.354970271105032 no 2184 0.362429529332227 690 2870548 SGTC_1303 1160-0052 261 µM -0.352794772588234 0.354615571403303 no 2185 0.362121151495068 704 3562476 SGTC_643 k048-0106 28.4 µM -0.355019820365106 0.353656663966778 no 2186 0.361287371338628 696 6763920 SGTC_1257 0669-0121 16 µM -0.355382801247585 0.353500321456672 no 2187 0.361151415836233 683 4307855 SGTC_484 loperamide 105 µM -0.357384790876408 0.352638472542352 no 2188 0.360401880550538 686 3955 An opioid-receptor agonist. SGTC_768 0384-0033 77.3 µM -0.358113207589739 0.352325079217187 no 2189 0.360129297710745 711 3965305 YMR134W ERG29 SGTC_2227 7312221 64.1025 µM -0.359591091433472 0.351689544050704 no 2190 0.359576473281584 693 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1276 0871-0068 94.2 µM -0.359746511283264 0.351622732813902 no 2191 0.359518353225371 691 3414906 SGTC_2759 disulfiram 3.38 µM -0.360311527486028 0.351379884632917 no 2192 0.35930708988456 681 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_621 3584-0052 32.1 µM -0.360539299615649 0.351282003621317 no 2193 0.359221936519694 731 2273927 SGTC_3191 9110352 49.47 µM -0.36112885565134 0.351028698244901 no 2194 0.359001561526425 709 17122424 SGTC_1911 st060208 74.3 µM -0.361416047474978 0.350905328963868 no 2195 0.35889422672451 705 688783 SGTC_3238 9133470 49.47 µM -0.361992588751181 0.350657711002314 no 2196 0.358678784368779 700 3534688 SGTC_2514 salinomycin 42.74 µM -0.362393760104247 0.350485449859251 no 2197 0.358528900893073 715 23682228 A polyether potassium ionophore. SGTC_443 clozapine 122 µM -0.362963704199401 0.350240771345307 no 2198 0.358315998928188 724 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_710 3448-4187 58 µM -0.363479256648102 0.350019496837336 no 2199 0.358123452833709 684 3946412 SGTC_448 monastrol 171 µM -0.363850244354529 0.349860300845124 no 2200 0.357984920415853 715 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_566 0958-0068 16.5 µM -0.364435183381829 0.349609348977496 no 2201 0.357766533330011 729 6815365 SGTC_777 1315-0167 517 µM -0.364455619892507 0.349600582446638 no 2202 0.357758904196452 690 4221767 SGTC_595 3909-8003 73.7 µM -0.365626691781493 0.349098368674524 no 2203 0.357321827517086 725 699517 SGTC_2225 6654152 15.4 µM -0.365936285893416 0.348965643461932 no 2204 0.357206309612299 718 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1478 0453-0656 35.7 µM -0.365969933343182 0.348951219672151 no 2205 0.357193755630455 718 5258496 SGTC_3159 9100096 49.47 µM -0.367275404544518 0.348391766684246 no 2206 0.356706799205284 670 25236875 SGTC_1220 1838-0075 193 µM -0.3673681924886 0.348352015420907 no 2207 0.356672197065172 700 5529645 SGTC_1581 himbacine 57.9 µM -0.368588832102175 0.347829236691372 no 2208 0.356217110527237 738 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3178 9107506 49.47 µM -0.369122463480963 0.347600782426037 no 2209 0.356018222992918 708 8897194 SGTC_3279 9140807 49.47 µM -0.369546222972596 0.347419405102862 no 2210 0.355860313255224 699 45595718 SGTC_2812 7970281 58.44 µM -0.369705252453421 0.347351346397131 no 2211 0.355801058888818 729 2233435 SGTC_1957 st077035 62.4 µM -0.370814838459202 0.346876621906854 no 2212 0.355387724291121 722 705593 SGTC_761 k216-0224 480 µM -0.370955231092657 0.346816573530395 no 2213 0.355335438396492 760 1340404 SGTC_2824 7998404 51.95 µM -0.370960303025129 0.346814404248471 no 2214 0.355333549526925 718 837851 SGTC_779 1360-0071 233 µM -0.371329597973336 0.346656469102619 no 2215 0.355196027676434 718 7566 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.371481345885262 0.346591579299297 no 2216 0.355139523693868 752 5282309 SGTC_2984 9022109 38.96 µM -0.371835992131112 0.346439944518889 no 2217 0.355007482073166 729 6459207 SGTC_631 k072-0230 41.5 µM -0.374018198580115 0.345507448918036 no 2218 0.354195388344217 715 5773147 SGTC_1944 st076371 56.9 µM -0.37455792583469 0.345276958151922 no 2219 0.353994634478815 702 24208455 SGTC_361 000s-0510 1.45 µM -0.374743945256615 0.345197531764795 no 2220 0.353925453158329 705 660 SGTC_1518 st038567 90.8 µM -0.374753447495476 0.34519347469134 no 2221 0.353921919369513 727 77966 SGTC_2571 chrysanthemic acid 100 µM -0.376480011123251 0.344456597252938 no 2222 0.353280036547878 760 2743 An insecticide. SGTC_3024 9090631 49.47 µM -0.376865436041615 0.344292182792336 no 2223 0.353136804403553 682 25236383 SGTC_1798 st045719 60.953 µM -0.378050525317487 0.3437868321524 no 2224 0.352696530279539 710 3980186 SGTC_396 dithiazanine 1.25 µM -0.379483579408411 0.343176116030879 no 2225 0.352164397881288 700 10578 An antihelmenthic. SGTC_1334 1486-0610 236 µM -0.379652820753381 0.343104018452657 no 2226 0.352101572997763 676 3742339 SGTC_611 3453-1652 23.7 µM -0.380306309733985 0.342825682814767 no 2227 0.351859026147818 726 1560575 SGTC_1618 st003135 44.5 µM -0.380680639671686 0.342666285694333 no 2228 0.351720118207403 751 1270615 SGTC_886 0866-0150 153 µM -0.381090104382453 0.342491959566225 no 2229 0.351568194973874 703 271463 SGTC_16 erodoxin 22.806 µM -0.381889053269824 0.342151910468712 no 2230 0.351271830132463 727 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_509 pifithrin 175 µM -0.382319804732709 0.341968626853343 no 2231 0.351112083209036 725 4817 A p53 inhibitor. SGTC_1020 4335-0961 93.3 µM -0.382629286799071 0.341836966030781 no 2232 0.350997326051636 741 669075 SGTC_3009 9080819 71.4286 µM -0.383253510674224 0.341571465306265 no 2233 0.350765902757958 728 17027216 SGTC_3256 9138902 49.47 µM -0.383502057118813 0.341465773019436 no 2234 0.35067377263757 729 17228773 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.383897168667568 0.341297780744994 no 2235 0.350527332475978 711 616764 SGTC_961 1252-1571 372 µM -0.384899558432527 0.340871728991377 no 2236 0.350155916533573 746 6813498 SGTC_3263 9137018 49.47 µM -0.386167073346952 0.340333280000796 no 2237 0.349686468812057 712 43844957 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.386559046822187 0.340166832806448 no 2238 0.349541340621229 719 75037 A free radical scavenger. SGTC_1387 3342-1166 1.8 µM -0.386827734275871 0.340052755642931 no 2239 0.349441871784443 706 3418228 SGTC_3138 9097216 49.47 µM -0.38712505105353 0.339926540335698 no 2240 0.349331816341974 727 25237486 SGTC_1362 1611-0397 101 µM -0.387127744463548 0.339925397025851 no 2241 0.349330819401187 706 27816 SGTC_1900 st060200 72.8 µM -0.387720242462887 0.339673926821238 no 2242 0.349111537027824 691 688945 SGTC_1476 4112-3294 3.34 µM -0.387874111451634 0.339608632838553 no 2243 0.349054598646218 718 704369 SGTC_76 0433-0009 400.328 µM -0.388722141262176 0.339248859580661 no 2244 0.348740850835385 771 2841569 SGTC_2018 5133068 143 µM -0.390068314564254 0.338678051900332 no 2245 0.348243016014869 745 785362 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.390839461958619 0.338351234849166 no 2246 0.347957951975481 730 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3 0833-0587 95.581 µM -0.391741783571411 0.337968979915074 no 2247 0.347624506862166 702 5382644 SGTC_2442 5158906 48.48 µM -0.393528123465501 0.337212716899633 no 2248 0.346964728275134 691 1893835 SGTC_2682 pyrogallin 40.03 µM -0.393754538282905 0.337116909030513 no 2249 0.346881135799774 726 822798 An ATP competetive kinase inhibitor. SGTC_2367 9070478 135.38 µM -0.394049665051044 0.336992041425977 no 2250 0.346772186022464 696 572802 SGTC_905 2-aminofluorene 215 µM -0.394413048123175 0.336838319374805 no 2251 0.346638055972174 693 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1090 efavirenz 20.7 µM -0.394596046180363 0.336760915967135 no 2252 0.346570515967572 702 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_877 0771-0151 33.1 µM -0.394734573507216 0.336702327116816 no 2253 0.346519392240041 723 6166523 SGTC_45 0kpi-0036 14.9 µM -0.395778273349592 0.336261031432907 no 2254 0.34613430310458 737 2795021 SGTC_2889 9059656 51.95 µM -0.395880821856184 0.336217684177195 no 2255 0.3460964748283 713 3949838 SGTC_2391 6285546 200 µM -0.396766253467044 0.335843502837924 no 2256 0.345769919142469 701 846083 SGTC_48 0382-0018 55 µM -0.397171278007361 0.335672394608955 no 2257 0.345620580421771 703 762596 SGTC_3354 9151612 71.43 µM -0.397408213711121 0.335572313628875 no 2258 0.345533229751852 725 27261949 SGTC_2154 5570129 200 µM -0.400379930467071 0.334318061346075 no 2259 0.344438351977839 747 673366 SGTC_3201 9113999 49.47 µM -0.400511390064895 0.334262619658251 no 2260 0.344389947967608 739 16649224 SGTC_3115 9123671 49.47 µM -0.401038240709613 0.334040462290396 no 2261 0.34419598479046 728 3286988 SGTC_1742 st038235 28.8875 µM -0.401434369299496 0.333873464841098 no 2262 0.344050174695505 747 564103 YBR002C RER2 SGTC_44 0929-0055 61.211 µM -0.401631626466873 0.333790318647355 no 2263 0.343977575387744 685 1379590 SGTC_2674 ligustilide 100 µM -0.40435111805057 0.332644854584665 no 2264 0.342977270210477 696 5319022 A signalling regulator. SGTC_2492 derrusnin 100 µM -0.406112599029044 0.331903741652762 no 2265 0.342329934437851 750 1715307 Part of coumarin class of compounds. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.406114174710608 0.331903079005548 no 2266 0.342329355589445 724 5024745 SGTC_2801 7907800 81.82 µM -0.40636869357149 0.331796048917521 no 2267 0.34223585943038 759 6620925 SGTC_299 1273-0059 1.44 µM -0.407540762842528 0.331303348465982 no 2268 0.341805430847361 710 2848077 SGTC_2178 5812956 200 µM -0.407811384023312 0.331189629416697 no 2269 0.341706077609402 708 5403383 SGTC_1161 k007-0610 110 µM -0.407922947845495 0.331142753168705 no 2270 0.341665122340151 741 5843850 SGTC_752 1896-0090 130 µM -0.408447038261998 0.330922579283871 no 2271 0.341472752805287 705 772567 SGTC_219 mitoxanthrone 164.414 µM -0.409213171763075 0.330600826700992 no 2272 0.341191614466514 732 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1939 st074455 53.6 µM -0.40985827795717 0.330329998917447 no 2273 0.340954956328857 755 1644229 SGTC_2173 5763948 167 µM -0.410227314422881 0.330175110371184 no 2274 0.340819602896218 719 2867177 SGTC_2549 cedrol 20.94 µM -0.411569692266315 0.329611945652423 no 2275 0.340327424893722 728 6708665 A sedative which affects the nervous system. SGTC_2264 7948757 110.76 µM -0.412487277563549 0.329227215285219 no 2276 0.33999115192263 716 2971411 SGTC_2775 cyproheptadine 69.59 µM -0.413513321800424 0.328797223725598 no 2277 0.339615282069828 731 2913 A selective serotonin reuptake inhibitor. SGTC_3314 9135860 59.4275 µM -0.414710730853486 0.32829570355247 no 2278 0.339176837931443 729 25252478 SGTC_3197 9113331 49.47 µM -0.415531706866729 0.327952026424701 no 2279 0.338876354527926 722 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_266 formosanin C 406 nM -0.415705237720661 0.327879401542495 no 2280 0.33881285404414 716 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_863 0466-0191 129 µM -0.416096210799711 0.327715798162861 no 2281 0.338669801291561 744 765160 YPR165W RHO1 SGTC_1148 3909-7663 27.7 µM -0.418460148220976 0.326727309684361 no 2282 0.337805358920275 758 4084526 SGTC_2465 5809242 33.21 µM -0.420448603874357 0.325896770592414 no 2283 0.337078884039242 753 2731748 SGTC_1031 k035-0009 16 µM -0.420454428241574 0.325894339133892 no 2284 0.337076757018923 746 5180959 SGTC_252 miconazole 1.30953 nM -0.42180390978529 0.325331180140857 no 2285 0.336584075838568 737 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_415 dibenzyl ketone 100 µM -0.421942874721077 0.325273210595322 no 2286 0.336533357146253 747 7593 SGTC_903 1134-0042 114 µM -0.42248886706051 0.325045489573167 no 2287 0.336334112533221 710 701009 SGTC_2941 9056145 11.23 µM -0.422808618600328 0.324912158789321 no 2288 0.336217449497898 755 2119517 SGTC_29 0299-0004 12.984 µM -0.425702708767354 0.323706395672847 no 2289 0.335162244002002 741 16871 A napthoquinone isolated from Swertia calycina. SGTC_2649 anisomycin 9.56 µM -0.42634340711449 0.323439711313612 no 2290 0.334928816305381 735 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3102 9121669 49.47 µM -0.426877925599784 0.323217292644833 no 2291 0.334734122238093 735 41905072 SGTC_4 0960-0234 25.671 µM -0.427088185899761 0.323129818469442 no 2292 0.334657548782253 708 6821112 SGTC_1778 st046819 58.9 µM -0.42935827267247 0.322186022401565 no 2293 0.333831257742354 735 671715 SGTC_2909 7941780 10.49 µM -0.429363876313637 0.322183694083968 no 2294 0.33382921906224 737 1243215 SGTC_3198 9112019 49.47 µM -0.430070918113131 0.32188997363315 no 2295 0.333572027106506 781 45595555 SGTC_2111 5486399 200 µM -0.430157267078623 0.321854110025118 no 2296 0.33354062235434 722 689674 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.430786263759063 0.321592916793704 no 2297 0.333311894139918 704 115019 SGTC_1804 st050076 49.1 µM -0.430813727271985 0.321581514474854 no 2298 0.333301908725505 730 3895976 SGTC_3324 9138759 60.749 µM -0.431478676484147 0.321305491759014 no 2299 0.333060176986897 735 45595710 SGTC_1956 st077085 54 µM -0.431521017270229 0.321287919292225 no 2300 0.333044787013191 753 24208685 SGTC_1366 1683-0113 21.9 µM -0.432552088246974 0.32086012306811 no 2301 0.33267010152962 732 708623 SGTC_3296 9122258 64.045 µM -0.432671149382555 0.320810739340794 no 2302 0.332626846125968 744 4730474 SGTC_1902 st060212 70.5 µM -0.432945831536558 0.320696819812366 no 2303 0.332527061462872 707 688944 SGTC_2798 7813637 45.45 µM -0.433850052735863 0.320321929505319 no 2304 0.332198665996933 767 956368 SGTC_2098 5376439 882.5 nM -0.437811880555151 0.318681519943792 no 2305 0.330761328975916 719 2844116 SGTC_1376 2910-0861 41.3 µM -0.438151134068943 0.318541215186638 no 2306 0.330638364534581 741 1112859 SGTC_2900 5328528 85.29 µM -0.439927624898315 0.317806938721502 no 2307 0.329994763626836 715 795359 SGTC_1945 st075991 56.6 µM -0.440398254322196 0.317612533420794 no 2308 0.329824344517657 730 1084980 SGTC_1082 camptothecin 424.86 nM -0.443139872623924 0.316481040157457 no 2309 0.328832283209342 745 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1171 0368-0077 21.4 µM -0.443199565152832 0.316456423500183 no 2310 0.3288106966982 719 3239779 SGTC_1633 st005664 67.9 µM -0.443225603710599 0.31644568568994 no 2311 0.328801280596226 758 2063822 SGTC_3025 9087895 49.47 µM -0.443597844327028 0.316292197599444 no 2312 0.32866668227468 725 17173641 SGTC_1060 3448-7350 82 µM -0.444172283706044 0.316055397847241 no 2313 0.328459014606481 755 570178 SGTC_2079 5212404 121 µM -0.44431509030959 0.315996540732696 no 2314 0.328407396292505 738 758462 SGTC_3322 9139058 2.11 µM -0.444712425565371 0.315832805295157 no 2315 0.328263794287587 726 4908926 YPR165W RHO1 SGTC_1812 st052057 4.327 µM -0.445951761441034 0.315322327229005 no 2316 0.327816045644815 737 3645418 SGTC_1312 1218-2183 165 µM -0.446211527334255 0.315215375210368 no 2317 0.327722228477233 753 6744073 SGTC_2276 7947513 42.08 µM -0.446958965261215 0.314907723007342 no 2318 0.327452344131521 752 2105100 SGTC_1591 genipin 88.4 µM -0.447411572030585 0.314721488370008 no 2319 0.327288961020488 758 442424 A DNA cross-linking agent. SGTC_962 1254-0300 21.5 µM -0.448347651313311 0.31433646826458 no 2320 0.326951157799003 730 7340576 SGTC_3264 9137442 49.47 µM -0.449484362413357 0.313869197455116 no 2321 0.326541143102169 749 17015726 SGTC_521 r062-0005 13.8 µM -0.450744251696453 0.313351640048327 no 2322 0.326086942436673 734 2832033 SGTC_1331 1472-0049 76.2 µM -0.45134474214858 0.313105090210115 no 2323 0.32587055129152 748 24051409 SGTC_259 usnic acid 108.925 µM -0.45152655114663 0.313030459399861 no 2324 0.325805046645685 784 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_153 4077-0274 519.67 µM -0.452485111390961 0.312637106537046 no 2325 0.325459772331798 683 3121976 SGTC_2259 7964009 200 µM -0.453506916154565 0.31221803565707 no 2326 0.32509188215654 732 313134 SGTC_3097 9117246 49.47 µM -0.455049316301747 0.311585914005204 no 2327 0.324536879941964 716 16423892 SGTC_3158 9100007 49.47 µM -0.455450517080421 0.311421580804989 no 2328 0.324392579545236 725 19297233 SGTC_3000 9075062 71.4286 µM -0.455984489780494 0.311202922048613 no 2329 0.324200565801752 743 17057871 SGTC_1047 2043-3044 82 µM -0.456303893181301 0.31107216002085 no 2330 0.324085732378488 796 669592 SGTC_1463 k081-0032 34.1 µM -0.456329637774941 0.311061621361462 no 2331 0.324076477288947 744 977755 SGTC_1741 st038134 10.228 µM -0.45678492369357 0.310875273727595 no 2332 0.323912821594171 758 1272587 SGTC_462 ag-879 158 µM -0.457528244991053 0.310571138005821 no 2333 0.323645702725269 755 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1326 1431-2094 10.8 µM -0.458794643098946 0.310053279490009 no 2334 0.323190820984815 768 616278 SGTC_433 pimozide 108 µM -0.459089194398236 0.309932884813575 no 2335 0.323085057978597 734 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_985 1493-0307 8.71 µM -0.46073439483688 0.309260801914348 no 2336 0.322494587611625 750 3278274 SGTC_403 arphamenine a 50 µM -0.460780869560485 0.309241825718027 no 2337 0.322477914101245 763 5487158 An arginine aminopeptidase inhibitor. SGTC_873 0591-4978 488 µM -0.46200835385113 0.308740813241249 no 2338 0.322037664877013 780 3305145 SGTC_1434 4073-0095 163 µM -0.46259584273144 0.308501148410311 no 2339 0.32182704454061 756 24133745 SGTC_3002 9075603 71.4286 µM -0.463000180588545 0.308336247030398 no 2340 0.321682118830062 728 20105405 SGTC_2942 9052777 62.25 µM -0.463177123211227 0.308264096562353 no 2341 0.321618706302953 772 6469503 SGTC_253 dyclonine 31.25 µM -0.463564120633113 0.308106319558731 no 2342 0.321480032653567 733 3180 An oral anasthetic. SGTC_131 0141-0277 33.849 µM -0.463787423780406 0.3080152960597 no 2343 0.321400027255558 763 1547771 SGTC_2320 7373003 200 µM -0.463807517632325 0.308007105922528 no 2344 0.321392828405397 750 5415828 SGTC_2699 st077704 54.6 µM -0.464455607468804 0.307742999571464 no 2345 0.321160678867791 741 645852 SGTC_1564 D-Arginine 115 µM -0.465888936715054 0.307159250182661 no 2346 0.320647500264106 785 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2865 9030313 51.95 µM -0.468317247561889 0.306171391469501 no 2347 0.319778868060053 753 42562754 SGTC_1887 st057648 70.8 µM -0.468639325388315 0.306040472893643 no 2348 0.319663731520529 753 688672 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.468855801556744 0.30595249332373 no 2349 0.319586355277878 732 2333 A French combination drug. SGTC_3323 9138564 53.9225 µM -0.469007018859755 0.305891042699499 no 2350 0.319532309521537 727 43912313 YNL103W MET4 SGTC_2307 7538926 6.34 µM -0.469010967265016 0.305889438247524 no 2351 0.319530898394764 732 96582 SGTC_477 mead ethanolamide 10 µM -0.469336208317868 0.305757287898259 no 2352 0.319414668957613 724 16061185 SGTC_2112 5488546 200 µM -0.469463944839064 0.305705393537505 no 2353 0.319369025377488 771 600757 SGTC_157 1348-1695 65.819 µM -0.470588080078455 0.305248869639747 no 2354 0.318967460727109 716 5380510 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.470623858574492 0.305234344560541 no 2355 0.31895468338415 713 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_306 1672-3436 11.6 µM -0.47292043764629 0.304302639528364 no 2356 0.318134971636919 770 6797378 SGTC_201 4262-0159 12.803 µM -0.472923253831032 0.304301497800942 no 2357 0.318133967009273 750 1341029 SGTC_59 0330-0160 1.33 µM -0.473476035604715 0.30407742796221 no 2358 0.317936797106821 771 4293482 SGTC_163 TUB2.036 7.546 µM -0.476633190582645 0.30279908858457 no 2359 0.31681167226375 761 15992207 YJR013W GPI14 SGTC_2051 5263410 176 µM -0.477017053033749 0.302643826012828 no 2360 0.31667498922606 761 227584 SGTC_207 4185-0010 4.486 µM -0.478106501963735 0.302203366125849 no 2361 0.31628720227969 735 3761753 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.478855967409867 0.301900527355193 no 2362 0.316020548925305 772 91467 include heat shock SGTC_2147 5545932 89.7195 µM -0.478980391874705 0.30185026398585 no 2363 0.315976289029584 775 797404 SGTC_3312 9133330 71.43 µM -0.479222606293972 0.301752428157845 no 2364 0.315890136811829 769 17617324 SGTC_309 k408-0051 1.48 µM -0.480374416644806 0.301287381375845 no 2365 0.315480591184093 749 3640463 SGTC_3134 9127454 49.47 µM -0.481129955787201 0.300982505655097 no 2366 0.31521206949041 759 24262820 SGTC_1142 3253-1408 9.78 µM -0.484787421948673 0.299508612672598 no 2367 0.313913572942106 764 256655 SGTC_1455 4262-0120 131 µM -0.48539638382255 0.299263530048274 no 2368 0.313697598508199 741 1529587 SGTC_615 k087-0205 167 µM -0.485700804639511 0.299141047052331 no 2369 0.313589656539519 760 9642773 SGTC_2643 anethole 100 µM -0.48795880378053 0.298233257632449 no 2370 0.312789510676467 780 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1588 farnesol 29.9 µM -0.488321030123758 0.298087747652305 no 2371 0.312661233874124 736 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1628 st004252 77.7 µM -0.48856147658378 0.297991175747497 no 2372 0.312576096043389 717 692968 SGTC_1800 st050079 29.0735 µM -0.490663451820887 0.297147555172297 no 2373 0.311832250124578 757 3645560 SGTC_703 3875-0075 71.8 µM -0.492197779891698 0.296532448098128 no 2374 0.311289766883674 782 2850814 SGTC_849 0386-0493 241 µM -0.49269256746441 0.296334213864359 no 2375 0.311114915066021 761 726119 SGTC_1512 0259-0544 12.2 µM -0.492799408050991 0.296291416681307 no 2376 0.311077164516188 724 18476 SGTC_3313 9133968 57.047 µM -0.492920364245271 0.296242968623947 no 2377 0.311034428822793 760 1494643 SGTC_137 0438-0332 85.389 µM -0.494967580918975 0.295423523780775 no 2378 0.310311502407405 789 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_409 arachidonic acid 100 µM -0.494993266577807 0.295413249140272 no 2379 0.310302436767152 742 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1123 mangostin 811.285 nM -0.495378309257938 0.295259246123577 no 2380 0.310166551464713 728 5281650 An antioxidant. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.495803602413056 0.295089187347847 no 2381 0.310016491501159 753 66535 A nucleotide analog. SGTC_1569 carminic acid 40.6 µM -0.497607436216287 0.294368403812581 no 2382 0.309380380710209 750 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_736 0958-0254 92.6 µM -0.498569581514253 0.293984278462312 no 2383 0.309041319438651 786 6812352 SGTC_827 3253-0474 693 µM -0.500318078166776 0.293286805383668 no 2384 0.30842556333862 774 5402065 SGTC_2067 5224629 34.075 µM -0.501669934409034 0.292748077946568 no 2385 0.307949858376847 762 2835000 SGTC_2133 5320837 200 µM -0.502941890498117 0.292241611458999 no 2386 0.307502563962133 762 2841355 SGTC_1981 st071826 47 µM -0.50320991138669 0.292134943125785 no 2387 0.307408348557117 728 11838600 SGTC_2618 avocadyne 43.43 µM -0.504424487197483 0.29165178723574 no 2388 0.306981557014396 774 3015189 SGTC_367 0335-0881 7.1 µM -0.504869258202175 0.291474951422087 no 2389 0.306825333653923 782 23828853 SGTC_1670 st016595 4.04 µM -0.506385810706765 0.290872363973113 no 2390 0.306292916800061 778 597879 SGTC_455 paf C-16 10 µM -0.508260060074469 0.290128454670231 no 2391 0.305635487914909 763 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2991 9074669 71.4286 µM -0.508611788738913 0.289988949280592 no 2392 0.305512182052238 792 17333109 SGTC_991 3996-0057 64.7 µM -0.509101569468054 0.289794741000558 no 2393 0.30534051588566 743 715343 SGTC_3227 9130768 49.47 µM -0.509263538024576 0.289730530516696 no 2394 0.305283755976588 771 17720899 SGTC_31 0508-1974 57.237 µM -0.509387042700893 0.289681573061784 no 2395 0.305240478412043 738 6810525 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.51049169524007 0.289243859762228 no 2396 0.304853515648766 760 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3196 9111891 49.47 µM -0.510672310038898 0.289172321591322 no 2397 0.304790266538834 781 18891510 SGTC_1433 4060-0023 7.6 µM -0.511728819629187 0.288754024487903 no 2398 0.304420406619289 746 3840627 SGTC_1297 1068-0111 14.1 µM -0.511892369082539 0.288689296869286 no 2399 0.304363169545288 764 767057 SGTC_1453 4237-0541 195 µM -0.512674682876459 0.288379776760313 no 2400 0.304089451054176 767 739892 SGTC_2301 7769476 200 µM -0.512730223445517 0.288357808249731 no 2401 0.304070022510821 763 977820 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.513553394143799 0.288032303948317 no 2402 0.303782135587114 756 676296 Flavone; oxidizing agent. SGTC_889 0919-1524 82.7 µM -0.514979510277201 0.287468789325943 no 2403 0.303283669054902 761 3905452 SGTC_2333 9017922 200 µM -0.515270039729434 0.28735405366027 no 2404 0.303182165923112 762 3163164 SGTC_1183 1254-0324 198 µM -0.515463755386769 0.287277563663723 no 2405 0.303114495354958 747 5799357 SGTC_13 0199-0087 65 µM -0.517175813228528 0.286601964751782 no 2406 0.302516717228213 765 4589825 SGTC_2244 6635614 200 µM -0.5179963569313 0.286278435548848 no 2407 0.302230405567229 763 836499 SGTC_1411 3909-8223 150 µM -0.51858007551224 0.286048388874035 no 2408 0.302026803160881 784 X1411 SGTC_823 0417-1665 178 µM -0.519461809959725 0.285701059177938 no 2409 0.301719368984324 787 3429856 SGTC_1265 0819-1001 68.8 µM -0.519515307652507 0.285679992014787 no 2410 0.301700720482481 758 3106768 SGTC_2343 7990716 14.84 µM -0.519579142125306 0.285654855238917 no 2411 0.301678469410694 776 6456862 SGTC_374 0880-0231 82.3 µM -0.520059993843183 0.285465538999135 no 2412 0.301510880467936 763 6833587 SGTC_356 1634-0012 32.5 µM -0.520329637269553 0.285359403772296 no 2413 0.301416921273655 795 735457 SGTC_1024 4507-0395 26 µM -0.520393254942491 0.285334365753454 no 2414 0.301394755158965 735 4201836 SGTC_3171 9103192 49.47 µM -0.521132372991799 0.285043547662178 no 2415 0.301137280283032 775 13018434 SGTC_2400 5203494 178.7 µM -0.521230628221358 0.285004898179095 no 2416 0.301103060125752 777 6777674 SGTC_117 lucigenin 22.078 µM -0.521786829329981 0.284786159134651 no 2417 0.300909380435118 788 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1548 st061468 90.8 µM -0.523556676231389 0.284090659162609 no 2418 0.300293460600286 767 390799 SGTC_2117 5521686 200 µM -0.526497819899514 0.282936672670616 no 2419 0.299271183174664 761 803312 SGTC_1826 st055655 41.6 µM -0.526986668545856 0.28274508647714 no 2420 0.29910142317234 761 676168 SGTC_1424 4048-1941 275 µM -0.527574173689262 0.282514918008439 no 2421 0.298897461083842 764 X1424 SGTC_146 3448-8650 53.125 µM -0.527702291175272 0.282464737044412 no 2422 0.298852991381256 798 2891488 YIL048W NEO1 SGTC_250 brefeldin a 552.239 µM -0.529697679945672 0.281683738385998 no 2423 0.298160778394478 765 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_145 3737-0113 38.366 µM -0.530707135440433 0.281289032713597 no 2424 0.297810870314948 764 6849351 SGTC_2317 5986382 200 µM -0.531890650862625 0.280826608437684 no 2425 0.297400866432989 796 877883 SGTC_2431 5490079 200 µM -0.533650132880256 0.280139822081434 no 2426 0.296791808150099 817 5722345 SGTC_2210 7115885 190.385 µM -0.533727773515752 0.280109535030367 no 2427 0.296764945402998 790 2927039 SGTC_2938 9059746 27.26 µM -0.533736601934821 0.280106091228343 no 2428 0.296761890944272 783 6471769 SGTC_796 1234-0020 70.7 µM -0.534571393864883 0.279780547164758 no 2429 0.296473134462999 742 46495034 SGTC_2468 5987765 72.9 µM -0.534874620006247 0.279662343437127 no 2430 0.296368279720746 740 26772094 SGTC_335 4077-0256 27.6 µM -0.534919614331847 0.279644805797611 no 2431 0.296352722258856 789 3121989 SGTC_277 nystatin 15.5 µM -0.535040173765674 0.279597817439379 no 2432 0.29631103887499 786 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1135 dihydrocapsaicin 536.708 nM -0.536370075733713 0.279079739116676 no 2433 0.295851404225271 785 107982 A Capsaicinoid. SGTC_1146 3579-1023 7 µM -0.53655901813284 0.279006172359602 no 2434 0.295786129391841 799 X1146 SGTC_1023 4482-3888 16 µM -0.538111511609085 0.278402049720034 no 2435 0.295250032767761 771 3303168 SGTC_75 0159-0059 199.013 µM -0.538246307237054 0.278349626714769 no 2436 0.295203507155537 822 5377270 SGTC_1725 st036284 20.55 µM -0.538537946481127 0.278236222548712 no 2437 0.295102857473187 749 707914 SGTC_2642 cholecalciferol 100 µM -0.538567874138049 0.278224586428686 no 2438 0.295092529821977 788 9821465 A vitamin D precursor, similar to steriods. SGTC_70 0141-0289 43.283 µM -0.538749759380138 0.27815387304895 no 2439 0.29502976713405 779 352408 SGTC_101 0490-5701 117.494 µM -0.538775654924357 0.278143806087098 no 2440 0.29502083192312 782 4661669 SGTC_998 3996-0085 177 µM -0.539728721602446 0.277773422549003 no 2441 0.294692064741239 783 715391 SGTC_2319 6033012 152.6 µM -0.540746517919265 0.277378149710624 no 2442 0.294341155299755 765 847246 SGTC_2727 riluzole 51.77 µM -0.542881899672107 0.27654974462509 no 2443 0.293605559538233 778 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_929 2805-0021 398 µM -0.542896018675122 0.276544271304149 no 2444 0.293600698661218 808 3098024 SGTC_2846 9008642 19.48 µM -0.54401671524961 0.27610999565847 no 2445 0.293214985213252 828 2992898 SGTC_1300 1094-0077 113 µM -0.544129494263145 0.276066311762509 no 2446 0.29317618274085 767 5532636 SGTC_1780 st038448 24.544 µM -0.544382666454274 0.275968260243115 no 2447 0.293089085606818 795 728868 YDL195W SEC31 SGTC_2228 7354201 200 µM -0.544481550467041 0.275929967918989 no 2448 0.293055070461321 791 753451 SGTC_3275 9138069 49.47 µM -0.546262591166251 0.275240716278552 no 2449 0.292442723433311 787 17617007 SGTC_1927 st060202 13.8 µM -0.546813837865086 0.27502755913243 no 2450 0.292253317617612 778 688887 SGTC_625 k213-0058 121 µM -0.546830403967891 0.275021154578393 no 2451 0.292247626464641 786 3655420 SGTC_2652 actinonin 100 µM -0.548034525435318 0.274555830895626 no 2452 0.291834098235824 775 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1578 josamycin 24.2 µM -0.54806503168661 0.274544047031044 no 2453 0.291823625096605 794 5282165 A P450 substrate. SGTC_3173 9105693 49.47 µM -0.549715044828078 0.2739070568244 no 2454 0.291257418070475 811 17096658 SGTC_1892 st058411 7.36 µM -0.552369033415137 0.272884015435833 no 2455 0.290347771161054 802 3934738 SGTC_3035 9091303 49.47 µM -0.553336877095971 0.272511409778585 no 2456 0.290016376885233 783 25237002 SGTC_622 1348-1566 26.3 µM -0.553496415438199 0.272450014112284 no 2457 0.289961767227026 770 7340407 SGTC_1217 1183-1422 255 µM -0.554747873877275 0.271968649652519 no 2458 0.289533562828853 768 2849664 SGTC_2940 9060638 45.86 µM -0.556282830364091 0.271378817880987 no 2459 0.289008761348738 762 4027022 SGTC_1391 3442-0225 151 µM -0.556883240655878 0.271148274097423 no 2460 0.288803602949521 762 5227075 SGTC_812 4251-0442 148 µM -0.557620882331703 0.270865170366742 no 2461 0.288551646892924 789 5723007 SGTC_1622 st003707 19.4 µM -0.557720850584034 0.270826814331731 no 2462 0.28851750873608 772 10140899 SGTC_2679 rapamycin 1 nM -0.558298976970148 0.270605050737982 no 2463 0.288320121704017 779 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_811 0416-0114 265 µM -0.559930230826588 0.269979807227582 no 2464 0.287763513796616 789 6612453 SGTC_2735 sertaconazole 140 nM -0.560268399393487 0.26985028108324 no 2465 0.287648189246096 800 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1348 1493-0373 93.8 µM -0.561191664741258 0.269496808244935 no 2466 0.287333442279541 807 3010129 SGTC_2681 menadione 3.18 µM -0.561907588999859 0.269222875928012 no 2467 0.287089491413156 791 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3184 9108758 49.47 µM -0.562335772852367 0.269059107780121 no 2468 0.28694363484415 784 902885 SGTC_1247 0448-0043 5.84 µM -0.563411736658359 0.268647803006379 no 2469 0.286577273507661 795 3089013 YGL099W LSG1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.563786657051864 0.268504557813211 no 2470 0.286449666772247 776 641818 YHR062C RPP1 SGTC_3151 9099821 49.47 µM -0.564567493714959 0.268206348197035 no 2471 0.286183990232436 804 17174189 SGTC_580 1123-0028 41 µM -0.565377763567039 0.267897074034103 no 2472 0.285908422967258 790 1677248 YPR107C YTH1 SGTC_1745 st081495 74 µM -0.568606210791259 0.266666585270979 no 2473 0.28481170450889 771 13842402 YBL026W LSM2 SGTC_805 3852-0218 479 µM -0.569372611567291 0.266374899870102 no 2474 0.284551649751432 779 6615355 SGTC_1838 st055369 84.5 µM -0.570910367904079 0.265790130646855 no 2475 0.284030201285814 749 676036 SGTC_251 melphalan 456.522 µM -0.571547299531867 0.265548112632177 no 2476 0.283814353690743 787 460612 A DNA alkylator. SGTC_3082 9117008 49.47 µM -0.573070889877448 0.264969640452993 no 2477 0.283298348177598 779 41448529 SGTC_764 1951-2361 146 µM -0.573137447780478 0.264944384554507 no 2478 0.283275816784996 770 5438930 SGTC_942 3253-1115 227 µM -0.573173027558036 0.264930884041248 no 2479 0.283263772558286 824 46497897 SGTC_1783 st039459 87.517 µM -0.573285071217193 0.264888372093625 no 2480 0.283225845897935 821 729761 SGTC_860 0443-0016 25.1 µM -0.573599493756188 0.264769091452637 no 2481 0.283119427211565 792 5337942 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.574009307148002 0.264613663946558 no 2482 0.282980751578465 758 3256 An antibiotic and ribosome inhibitor. SGTC_3163 9099914 49.47 µM -0.574128506837116 0.264568464498738 no 2483 0.282940422044312 803 16268368 SGTC_977 1348-1378 135 µM -0.575845689931055 0.263917760309926 no 2484 0.282359743807559 793 X977 SGTC_301 4119-0100 24.5 µM -0.576247160069668 0.263765746169891 no 2485 0.282224066425555 796 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_23 0213-0011 39.996 µM -0.57664517210861 0.263615085507137 no 2486 0.282089588693472 804 627608 SGTC_3321 9137793 26.8275 µM -0.577279540516059 0.263375046966644 no 2487 0.281875316198653 778 4904192 SGTC_1018 4259-0013 28.1 µM -0.578607706192818 0.26287284427316 no 2488 0.281426951894531 792 6801262 SGTC_746 1095-0025 46.6 µM -0.578841620250412 0.262784448012093 no 2489 0.281348022467853 811 6749286 SGTC_874 0599-0792 117 µM -0.579637837198465 0.262483671148536 no 2490 0.281079435755165 808 765305 SGTC_1381 2324-0066 62.1 µM -0.57978832559677 0.26242684284763 no 2491 0.281028685642834 808 10885928 SGTC_517 1365-0151 113 µM -0.580800278813333 0.262044866884981 no 2492 0.280687533576573 785 768657 SGTC_2012 4023501 200 µM -0.581275251241107 0.261865680192121 no 2493 0.280527478853825 823 3477460 SGTC_2356 9061756 188.97 µM -0.581633141723424 0.261730705013378 no 2494 0.280406907226226 769 20104043 SGTC_2019 4016004 108 µM -0.581708130362922 0.26170242824572 no 2495 0.280381647084416 796 45595336 SGTC_2959 9079155 11 µM -0.582300110451566 0.261479259031263 no 2496 0.280182275556345 813 16189457 SGTC_2521 angolensin 13.4 µM -0.582485985138281 0.261409206722494 no 2497 0.280119689447246 794 821428 A flavenoid. SGTC_1089 terbinafine 2.25 µM -0.587470268217162 0.259534334977659 no 2498 0.278443956485035 797 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2138 5575593 77.673 µM -0.588012220199038 0.259330895439074 no 2499 0.278262045226645 805 762213 SGTC_2680 butyl paraben 22.24 µM -0.588292596278029 0.259225679386471 no 2500 0.278167957117158 819 7184 An antifungal and steroid mimetic. SGTC_632 0781-2353 4.65 µM -0.589649522406777 0.258716780960961 no 2501 0.277712821614119 802 6811515 YHR007C ERG11 SGTC_2537 larixol 68.93 µM -0.590488467716577 0.258402403756071 no 2502 0.27743160752631 786 6708759 SGTC_2684 capsaicin 100 µM -0.590614322363551 0.258355259438066 no 2503 0.2773894331164 806 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1609 st001574 46.4 µM -0.590782366323219 0.258292318231735 no 2504 0.27733312578151 808 3960012 SGTC_1497 4476-2978 41.3 µM -0.591528494573672 0.258012950387307 no 2505 0.277083184358323 798 1528379 SGTC_2832 7992762 51.95 µM -0.593286347203663 0.257355389420767 no 2506 0.276494767079791 761 2985177 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.593473026352205 0.2572856094303 no 2507 0.276432314777657 782 5377381 SGTC_1350 1495-0454 146 µM -0.594098796229116 0.257051770668855 no 2508 0.276223017986766 791 1069057 SGTC_612 0302-0167 22.4 µM -0.594999667687616 0.256715325696501 no 2509 0.27592184655831 807 235821 SGTC_2266 7929956 200 µM -0.59555048074724 0.256509728677403 no 2510 0.275737783072717 803 2967153 SGTC_2304 7443016 91.4 µM -0.596067646458984 0.256316769005755 no 2511 0.275565018366645 814 939854 SGTC_2171 5739187 198.077 µM -0.59631057167102 0.256226157315429 no 2512 0.275483884994935 770 2262761 SGTC_2043 5101342 149 µM -0.596834800465609 0.256030675631063 no 2513 0.275308840500685 804 678451 SGTC_497 capsazepine 133 µM -0.596965146117854 0.255982082620948 no 2514 0.275265325467771 770 2733484 A calcium channel blocker. SGTC_645 0845-0943 5.41 µM -0.597035835728339 0.255955731464784 no 2515 0.275241727625384 784 1885106 SGTC_400 oxethazaine 37.5 µM -0.597124983748826 0.255922501535582 no 2516 0.275211969354731 801 4621 A local anesthetic. SGTC_3236 9132701 49.47 µM -0.597592088538045 0.255748425008179 no 2517 0.275056072208442 800 24282524 SGTC_2922 7999257 32.47 µM -0.598112009342136 0.255554738191742 no 2518 0.274882598782423 806 2988377 SGTC_2122 5258151 111.688 µM -0.598241839387414 0.255506384383984 no 2519 0.274839288940686 794 2173356 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.599628956550852 0.254990065970687 no 2520 0.274376772317089 817 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1594 piperine 70.1 µM -0.599669883216625 0.254974840375282 no 2521 0.274363131676997 791 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3317 9138495 8.753 µM -0.600043523223884 0.25483586029572 no 2522 0.274238614930447 813 17020139 SGTC_2602 kawain 100 µM -0.601699475109389 0.254220385886983 no 2523 0.273687099733259 795 5369129 SGTC_2055 5235184 200 µM -0.605124826138167 0.252949749631536 no 2524 0.272548029891837 829 2836034 SGTC_917 harmaline 728.087 nM -0.606022105571831 0.252617456497599 no 2525 0.272250037138641 777 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_758 0868-0029 16 µM -0.606522847457362 0.252432114739034 no 2526 0.27208380768711 782 762687 SGTC_3131 9127911 49.47 µM -0.606940590247069 0.252277548644562 no 2527 0.271945169761848 800 45595681 SGTC_909 3448-9333 149 µM -0.608892804204322 0.251555885589766 no 2528 0.271297747076539 806 3344074 SGTC_3044 9093193 49.47 µM -0.609335467490756 0.25139240077098 no 2529 0.271151051306348 813 25236277 SGTC_1125 tnp00248 1.32998 µM -0.609593023988831 0.251297305614271 no 2530 0.271065716942022 794 24207736 SGTC_1901 st060216 58.6 µM -0.612642148641435 0.250172952965912 no 2531 0.270056491222806 801 688792 SGTC_2389 9091542 195.52 µM -0.612725564210878 0.250142231343195 no 2532 0.270028908055993 800 3626624 YOL127W RPL25 SGTC_2172 5754775 163.918 µM -0.612836483577466 0.250101383281082 no 2533 0.269992232345921 790 2263357 SGTC_2776 terbinafine 19.92 µM -0.613151874424284 0.249985254237906 no 2534 0.269887961355675 782 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_262 fenpropimorph 62.5 µM -0.615924889948529 0.24896544416221 no 2535 0.268972046690757 826 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1975 st070967 30.8 µM -0.616775842978681 0.248652940393921 no 2536 0.268691293911126 806 261391 SGTC_1204 4049-0315 18.3 µM -0.617456608456795 0.248403086765286 no 2537 0.268466796740305 808 588402 SGTC_786 4544-0069 423 µM -0.617581602687835 0.248357226095475 no 2538 0.268425587433339 783 748821 YLR208W SEC13 SGTC_2334 9017922 200 µM -0.61816175961643 0.248144424292498 no 2539 0.268234357339187 806 3163164 SGTC_553 k007-0256 45.7 µM -0.618252450392782 0.248111167669796 no 2540 0.268204470234315 807 6287000 SGTC_2283 7944793 200 µM -0.618296782843567 0.248094911671305 no 2541 0.268189861104717 794 2970533 SGTC_681 1642-0006 26.6 µM -0.61912594882267 0.247790974525998 no 2542 0.267916695035292 827 4446530 SGTC_792 4534-1957 155 µM -0.619298189046115 0.247727863497638 no 2543 0.267859968628917 797 1717904 SGTC_1771 st048882 4.1505 µM -0.621116271561426 0.247062218525304 no 2544 0.267261561978984 789 4580403 SGTC_1488 4013-0813 75.9 µM -0.624460337783291 0.24584037597865 no 2545 0.266162654985454 794 2910057 SGTC_783 0848-0141 92.7 µM -0.624950482241654 0.245661561741449 no 2546 0.26600177909569 817 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3022 9087993 49.47 µM -0.629183690538299 0.244120115752198 no 2547 0.264614402508596 806 17173644 SGTC_3161 9100388 49.47 µM -0.629576824355025 0.243977228372081 no 2548 0.264485745275119 817 25236368 SGTC_352 k048-0007 5.11 µM -0.629806019418309 0.24389394656352 no 2549 0.264410753438106 827 6811911 SGTC_2207 7258803 200 µM -0.630026492222927 0.243813848609455 no 2550 0.264338625708246 825 3666799 SGTC_96 0929-0093 37.281 µM -0.630113237473043 0.243782337880034 no 2551 0.264310249725401 798 6991579 SGTC_2377 9073351 62.6 µM -0.630520818705851 0.243634311000097 no 2552 0.264176943098277 836 7337946 YHR072W ERG7 SGTC_1864 st057645 30.4 µM -0.630888305796839 0.243500887281089 no 2553 0.26405677933187 818 688666 SGTC_1159 4092-0538 61.2 µM -0.631502806799852 0.243277868310801 no 2554 0.263855907288854 818 717301 SGTC_156 3474-0145 5.642 µM -0.63219729536202 0.243025952655502 no 2555 0.263628982212226 801 2265471 SGTC_1655 st012546 55.1 µM -0.632288916292092 0.242992729029641 no 2556 0.263599052385457 808 720985 YLR208W SEC13 SGTC_1179 1021-1431 9.29 µM -0.632594285226061 0.242882013742119 no 2557 0.263499309977671 828 2840958 SGTC_1872 amphotericin b 148 nM -0.63593770963721 0.241671601204915 no 2558 0.262408511403108 802 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1288 0973-0013 65.5 µM -0.635990040795514 0.241652681934632 no 2559 0.262391456659267 808 4315430 SGTC_2441 5730946 39.09 µM -0.637863895080589 0.240975758032284 no 2560 0.261781141119167 801 1774275 SGTC_2157 5649910 96.377 µM -0.638024578874398 0.240917759569245 no 2561 0.261728840225325 812 2858091 SGTC_795 0685-0265 78 µM -0.638715380888651 0.240668502610547 no 2562 0.261504052480304 801 302754 SGTC_1 0258-0098 57.368 µM -0.642025252358533 0.239476176106102 no 2563 0.260428393494205 788 6790032 YDR047W HEM12 SGTC_2996 9066192 71.4286 µM -0.642180303623419 0.239420400648395 no 2564 0.260378060073657 808 6472854 SGTC_543 3844-1095 191 µM -0.646130431738374 0.238001845280104 no 2565 0.259097444306797 828 4230703 SGTC_1044 1222-0021 1.78 µM -0.646854293227577 0.237742395239649 no 2566 0.258863124863301 815 4306703 SGTC_3143 9086658 49.47 µM -0.646945234947884 0.237709810429056 no 2567 0.258833694094664 815 25236626 SGTC_2371 9071574 200 µM -0.647223915721031 0.237609973165355 no 2568 0.258743517565393 814 45596039 SGTC_2448 5185112 27.17 µM -0.647963372285927 0.23734517473923 no 2569 0.258504320385002 795 5718189 SGTC_476 mead acid 10 µM -0.648953242611959 0.236990957266802 no 2570 0.258184299485172 821 5312531 An omega 9 fatty acid. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.649497184440349 0.236796435641097 no 2571 0.258008532867564 809 94937 An inhibitor of serotonin biosynthesis. SGTC_1816 st051957 91.6 µM -0.650859606396163 0.236309599037782 no 2572 0.257568559281264 830 674121 SGTC_1025 k007-0731 70 µM -0.651214248410763 0.236182964649073 no 2573 0.257454096948833 822 6256118 SGTC_1264 0783-0040 158 µM -0.652609991621254 0.235684940528434 no 2574 0.257003871239293 815 2855798 SGTC_1879 gemcitabine 100 µM -0.652628380314025 0.235678383008369 no 2575 0.256997942322575 837 60750 A nucleoside analog which inhibits DNA replication. SGTC_996 3970-0799 1.8 µM -0.653159665518024 0.23548896692062 no 2576 0.256826675082873 817 6615648 YGL040C HEM2 SGTC_1384 3089-0840 101 µM -0.653182640737942 0.235480777591621 no 2577 0.256819270038579 799 1069836 SGTC_2948 9070189 9.45 µM -0.658536720376503 0.233576651058447 no 2578 0.255096654762373 798 6473636 YDL196W YDL196W SGTC_603 3794-0023 45.9 µM -0.660180560229867 0.232993753101903 no 2579 0.254568982881413 831 3802260 SGTC_2700 st077718 96.8 µM -0.660708472161174 0.232806729513283 no 2580 0.254399644756746 814 904970 SGTC_620 0109-0052 432 µM -0.663017733643938 0.231989607728404 no 2581 0.253659598268328 834 493037 SGTC_1863 st057641 20.1 µM -0.663606409918488 0.231781562998273 no 2582 0.253471126840249 835 3921635 SGTC_1685 st024049 53.0905 µM -0.665175561952047 0.231227515359541 no 2583 0.252969104628708 823 1941139 SGTC_906 1165-0455 526 µM -0.666339681202842 0.230816957512926 no 2584 0.252597003785215 824 3252859 SGTC_1991 st073000 8.92 µM -0.668445894381161 0.230075180678127 no 2585 0.251924504055523 837 4301969 YIL048W NEO1 SGTC_2715 st079500 56.4 µM -0.669289986731375 0.229778278768382 no 2586 0.251655256510615 822 28246688 SGTC_2924 9010168 62.78 µM -0.669481863545602 0.229710817760778 no 2587 0.251594073087963 821 2993929 SGTC_922 1866-0035 480 µM -0.669687823058254 0.229638417832955 no 2588 0.251528407885417 832 3156169 SGTC_818 4072-2707 53.5 µM -0.670541925404266 0.22933831591561 no 2589 0.251256194705932 827 882871 SGTC_463 ikarugamyin 104 µM -0.671157579142843 0.229122132986269 no 2590 0.251060074757109 839 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3008 9078912 71.4286 µM -0.67136079658854 0.229050799560282 no 2591 0.25099535648438 824 16648731 SGTC_586 0957-0265 8.15 µM -0.672344852917744 0.22870555221533 no 2592 0.250682090858342 820 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3300 9124615 50.48 µM -0.672799199531556 0.228546247427411 no 2593 0.25053752353997 820 24824903 SGTC_965 1291-5240 308 µM -0.673533270494218 0.228288996345244 no 2594 0.250304044859708 843 2834598 SGTC_2223 6903751 107.57 µM -0.67402381854418 0.228117177273382 no 2595 0.250148085425986 819 5598863 SGTC_2697 mebhydrolin 72.4 µM -0.674063008454058 0.228103453776041 no 2596 0.250135628042258 835 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3080 9117754 49.47 µM -0.674523837990644 0.227942115617851 no 2597 0.249989167822002 829 9550191 SGTC_2636 apigenin dimethyl ether 100 µM -0.675419646295926 0.227628673517673 no 2598 0.249704593496978 839 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_180 1486-1293 102.781 µM -0.676367193941594 0.227297392148112 no 2599 0.249403770298966 821 4140536 SGTC_2470 5664817 21.68 µM -0.676376902825963 0.227293999137079 no 2600 0.249400688962953 829 2859561 SGTC_470 aa-861 153 µM -0.676527375777029 0.227241416272174 no 2601 0.249352935525217 821 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_957 1187-1561 14.1 µM -0.676723836984136 0.227172773102696 no 2602 0.249290594772239 824 1538454 SGTC_1555 citronellol 128 µM -0.67718636986089 0.227011211159328 no 2603 0.249143857313467 824 8842 A terpine precursor. SGTC_548 1436-0017 110 µM -0.677259303989328 0.226985741307946 no 2604 0.249120723328088 822 9677137 SGTC_1814 st052110 31.539 µM -0.677610561940609 0.226863098565254 no 2605 0.249009323779278 832 674163 SGTC_2778 tioconazole 65.09 nM -0.678206853386904 0.226654987273362 no 2606 0.248820273898024 834 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_473 2-arachidonoylglycerol 10 µM -0.678584295267754 0.226523312232639 no 2607 0.248700648188046 818 5282280 An endocannabinoid. SGTC_914 3820-6779 408 µM -0.678864719338425 0.226425510966031 no 2608 0.248611790952915 814 2893481 SGTC_2962 9082311 13.18 µM -0.678941168761766 0.226398852447456 no 2609 0.24858756955988 840 16459453 SGTC_1963 st076565 50.3 µM -0.679457364021549 0.226218897475648 no 2610 0.248424056846758 850 4914280 SGTC_1904 st060225 78 µM -0.682404185925297 0.225193131212683 no 2611 0.247491704814459 806 66595 SGTC_1760 st045453 10.4495 µM -0.684965045152785 0.224303859336011 no 2612 0.246682989375174 840 3323419 YIL048W NEO1 SGTC_2528 xanthyletin 44.79 µM -0.685080965181317 0.224263652713928 no 2613 0.246646415516116 849 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.685293603106616 0.224189910327806 no 2614 0.246579333801549 843 6708784 An antioxidant flavonoid SGTC_2728 chlorpromazine 9.18 µM -0.685444467025347 0.224137599388887 no 2615 0.246531746100848 875 2726 A thorazine and dopamine antagonist. SGTC_1409 3909-8004 61.9 µM -0.685648974578324 0.224066698988891 no 2616 0.246467245198 818 2119279 SGTC_1730 st033808 45.1 µM -0.685742946280076 0.224034124360704 no 2617 0.246437609913857 837 1045166 SGTC_771 0250-0039 27.3 µM -0.685793602031964 0.224016566017315 no 2618 0.246421635709564 844 3005115 SGTC_712 r015-0009 80.6 µM -0.685816131695109 0.224008757015902 no 2619 0.246414531197302 833 6813872 YLR060W FRS1 SGTC_2198 6589944 200 µM -0.688393801160116 0.223116333218353 no 2620 0.245602413185157 821 5290268 SGTC_2290 7904846 200 µM -0.69129469919209 0.222114428668404 no 2621 0.244690181158867 831 2962154 SGTC_125 0133-0007 11.75 µM -0.691578162942239 0.222016664619713 no 2622 0.244601139570509 832 26541 SGTC_1185 1319-0113 81.3 µM -0.692030811115249 0.221860601363608 no 2623 0.244458989987887 839 4672763 SGTC_747 3448-8087 38.7 µM -0.692031253994408 0.221860448699184 no 2624 0.244458850927964 854 5168703 SGTC_1604 st002052 72.4 µM -0.692388289317761 0.221737394938448 no 2625 0.24434675903566 820 6254834 YHR062C RPP1 SGTC_3224 9130643 49.47 µM -0.693165911142317 0.221469519221598 no 2626 0.244102719140251 829 17644395 SGTC_2464 5717415 7.67 µM -0.693797841992896 0.221251967562177 no 2627 0.243904498079546 824 5285744 SGTC_1842 st055362 61.2 µM -0.694497126133983 0.22101137105956 no 2628 0.243685251233138 816 676032 SGTC_1819 st053448 58.6 µM -0.694625385802477 0.220967258147844 no 2629 0.243645049477536 869 2857616 SGTC_3268 9137683 49.47 µM -0.695082376083216 0.220810124445979 no 2630 0.243501839399771 880 1953228 SGTC_287 k060-0039 29.6 µM -0.696947263806216 0.220169556329291 no 2631 0.242917898834755 836 5861974 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.698308774775232 0.21970256633722 no 2632 0.242492056415857 832 2724 A muscle relaxant with antifungal properties. SGTC_682 0kpi-0099 17 µM -0.698376630153666 0.219679307242283 no 2633 0.242470843741411 850 1714895 YML126C ERG13 SGTC_1675 st018485 24.5 µM -0.698871261746888 0.219509802857137 no 2634 0.242316244383641 842 3323024 SGTC_1572 epiandrosterone 68.9 µM -0.699161668378278 0.219410318959933 no 2635 0.242225501361985 827 441302 A steroid. SGTC_2733 amorolfine 100 µM -0.69947127168854 0.219304287439396 no 2636 0.242128780266186 863 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3072 9116419 49.47 µM -0.700148592755942 0.219072424342445 no 2637 0.241917255963725 826 17170162 SGTC_1363 1636-0063 10.4 µM -0.700463622332084 0.218964630280436 no 2638 0.241818907820098 827 6072185 SGTC_1126 isoteolin 1.0172 µM -0.701006575159804 0.218778919055636 no 2639 0.241649455928025 830 133323 SGTC_2156 5649887 115 µM -0.702276620213557 0.218344867841998 no 2640 0.24125333536338 846 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2589 lobaric acid 100 µM -0.702308509984962 0.218333975566383 no 2641 0.241243393650219 845 73157 A novel microtubule depolymerizer. SGTC_2374 9071832 200 µM -0.702980746217644 0.218104439304544 no 2642 0.241033874208413 830 17381698 SGTC_2372 9071633 200 µM -0.704726389688204 0.217509036203825 no 2643 0.240490262621134 831 21321366 SGTC_1154 4088-0362 150 µM -0.704781108941964 0.217490387769412 no 2644 0.240473233273638 834 6618304 SGTC_1600 coumarin 106 71.1 µM -0.705658109841215 0.21719163001491 no 2645 0.240200388750757 853 100336 A hepatotoxic, DNA x-linker. SGTC_824 1304-0008 100 µM -0.70632713580711 0.216963880167045 no 2646 0.239992360989563 832 768245 SGTC_1188 1403-0014 4.57 µM -0.706969385161959 0.216745375528408 no 2647 0.239792751639329 831 9614867 SGTC_1213 1315-0166 115 µM -0.707634751114678 0.216519140477748 no 2648 0.23958605327696 824 768401 SGTC_2017 5132927 60.65 µM -0.70775444317016 0.216478457771922 no 2649 0.239548880827343 825 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1394 3474-0001 65.7 µM -0.709244690301838 0.215972301045547 no 2650 0.239086322414022 817 5017666 YIL048W NEO1 SGTC_1937 st074714 47.2 µM -0.709663770531252 0.215830085667128 no 2651 0.238956331937462 830 17250970 SGTC_2166 5933061 31.504 µM -0.710378378859803 0.215587707692904 no 2652 0.238734763593313 848 2877375 SGTC_53 0973-0023 39.979 µM -0.712409068469006 0.214899808751479 no 2653 0.238105750803406 847 674768 SGTC_2450 5739737 12.93 µM -0.712620890608596 0.214828127209552 no 2654 0.238040190549536 841 2262825 SGTC_2155 5570423 76 µM -0.713279912631302 0.214605200117807 no 2655 0.237836282475947 854 797402 SGTC_2607 solasodine 47.35 µM -0.713554091503417 0.214512493372479 no 2656 0.237751476987142 856 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_119 0121-0043 24.815 µM -0.713648773195955 0.214480484529538 no 2657 0.237722195115028 851 1092378 SGTC_676 falcarinol 140 µM -0.714293240325177 0.214262684661227 no 2658 0.237522935618449 857 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3172 9105863 49.47 µM -0.714628578359871 0.214149406935897 no 2659 0.23741929043682 848 2348785 SGTC_3174 9107204 49.47 µM -0.714691560130947 0.214128135480528 no 2660 0.237399827007292 853 3938802 SGTC_1647 st011722 22.4 µM -0.714812383163386 0.214087332166834 no 2661 0.237362491186483 837 2854783 SGTC_1968 st069590 43.6 µM -0.714961264470184 0.214037059478177 no 2662 0.237316489444235 852 6384066 SGTC_931 2812-0076 566 µM -0.717848129069534 0.213063612252299 no 2663 0.236425466898121 846 3450959 SGTC_1147 3809-1045 12.3 µM -0.718180676891164 0.212951643668383 no 2664 0.236322945370989 832 325925 SGTC_366 0181-0206 4.31 µM -0.718244909128444 0.212930020683016 no 2665 0.236303145966089 847 274874 SGTC_2095 5432005 200 µM -0.718352570743883 0.212893780610328 no 2666 0.236269961627191 859 783734 SGTC_1847 st056231 15 µM -0.719237598654322 0.212596007025446 no 2667 0.235997268402064 833 5393180 SGTC_2972 9093619 59.92 µM -0.720601826905413 0.212137480044541 no 2668 0.235577264754075 823 25236256 SGTC_3274 9138298 49.47 µM -0.721037566837405 0.211991146625506 no 2669 0.235443200857767 844 17015756 SGTC_1358 1509-0022 2.48 µM -0.722175939594622 0.211609128534834 no 2670 0.235093157017867 852 3258434 SGTC_1687 st020778 55.3625 µM -0.722825892962627 0.211391196341111 no 2671 0.23489342864852 836 4259299 SGTC_936 3005-4620 401 µM -0.72381488314193 0.211059835947039 no 2672 0.23458969545683 845 777207 SGTC_1364 1653-0028 37.6 µM -0.724013303213248 0.210993392143082 no 2673 0.2345287839554 831 5718652 SGTC_1772 st048439 82.2 µM -0.725290231187925 0.210566087991013 no 2674 0.234136998730043 833 2927068 YDL195W SEC31 SGTC_1282 0886-0010 32.4 µM -0.725312554608837 0.210558622323624 no 2675 0.234130152714545 841 2836211 YNL267W PIK1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.726419480044637 0.210188625836082 no 2676 0.233790826381558 834 17037758 SGTC_1507 4075-3230 155 µM -0.727703014002091 0.209760075369707 no 2677 0.233397702468389 833 659771 SGTC_538 2922-0838 53.3 µM -0.727903264780938 0.209693261348928 no 2678 0.233336402260366 853 777039 SGTC_3079 9117512 49.47 µM -0.729611336551699 0.209123869039126 no 2679 0.232813895353845 892 7185044 SGTC_2009 4012297 12.05 µM -0.729758354792146 0.2090749025292 no 2680 0.232768952213491 843 45595307 SGTC_2364 9055074 200 µM -0.730622057335808 0.208787370523116 no 2681 0.232505017700604 857 6470630 SGTC_488 nitrendipine 139 µM -0.730744922043701 0.208746487029217 no 2682 0.232467485618139 847 4507 Dihydropyridine L-type calcium channel blocker. SGTC_279 1273-0055 2.93 µM -0.730999137547601 0.208661911258553 no 2683 0.232389839865337 862 2847562 SGTC_3250 9135583 49.47 µM -0.732336054257678 0.20821746069015 no 2684 0.231981739157949 841 7699353 SGTC_1643 st009866 20.2 µM -0.733797159865856 0.207732363613655 no 2685 0.231536185896338 825 3156273 YOR207C RET1 SGTC_2841 9004761 38.96 µM -0.733961279652175 0.207677916457008 no 2686 0.231486168609759 832 2991039 SGTC_1177 0983-0204 23.6 µM -0.734450343417324 0.207515718311859 no 2687 0.231337156845824 840 766818 SGTC_510 ag-490 170 µM -0.735155649837635 0.20728193511359 no 2688 0.231122352824769 842 5328779 SGTC_520 3584-0023 682 µM -0.736044290886138 0.206987605050475 no 2689 0.230851872008158 829 1340790 SGTC_1059 3448-6867 171 µM -0.736354113710111 0.206885045666371 no 2690 0.230757611017551 849 3934407 SGTC_1850 st056238 17 µM -0.738848827181429 0.206060327578941 no 2691 0.229999399385678 846 5393177 SGTC_2303 7774051 200 µM -0.740012139805513 0.205676419829006 no 2692 0.229646314094434 867 2953184 SGTC_1049 3226-0134 66 µM -0.740896135772064 0.205384974144644 no 2693 0.229378209337853 841 5702385 SGTC_2990 9074105 71.4286 µM -0.741596750627897 0.205154161926888 no 2694 0.229165846432733 862 6502001 SGTC_720 r052-1644 49.9 µM -0.741803332615261 0.205086134503756 no 2695 0.229103250559261 851 1422863 YOR257W CDC31 SGTC_2385 9074692 200 µM -0.741927959848231 0.205045101255611 no 2696 0.229065492222464 845 17046906 SGTC_1809 st050081 57.6 µM -0.743734931827826 0.204450708104024 no 2697 0.228518425971929 855 5036894 SGTC_2811 7967822 32.47 µM -0.744373914786044 0.20424076399206 no 2698 0.228325147743023 839 2232244 SGTC_2234 tolnaftate 200 µM -0.744592860127322 0.204168856895519 no 2699 0.228258942753915 860 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_706 4262-0057 46.9 µM -0.74580287579147 0.203771729656584 no 2700 0.227893251249982 859 883298 SGTC_718 1130-0073 349 µM -0.74659342071301 0.203512521627094 no 2701 0.227654510532534 860 6740020 SGTC_1768 st044301 37.178 µM -0.749175139832082 0.202667384945633 no 2702 0.22687582547196 890 3931349 SGTC_3239 9133757 49.47 µM -0.74955471930659 0.2025433050976 no 2703 0.226761465450028 879 17036923 SGTC_2093 5331342 194.4 µM -0.749695319025384 0.20249735631209 no 2704 0.226719113705596 837 33839 SGTC_1683 st010134 710 nM -0.750388917486704 0.20227077561865 no 2705 0.226510251845801 875 3818134 SGTC_1412 3909-8563 178 µM -0.751000465388754 0.20207112458011 no 2706 0.226326187852376 872 23767530 SGTC_776 4476-4378 112 µM -0.751524714760406 0.201900067665486 no 2707 0.226168466293402 889 2892008 SGTC_545 4218-0007 221 µM -0.752285945977505 0.201651840514114 no 2708 0.22593955883998 861 2840508 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.752474310097983 0.201590445760759 no 2709 0.225882936679398 876 4620898 SGTC_711 k292-0785 179 µM -0.753164810942214 0.201365482075154 no 2710 0.225675441105605 847 4146315 SGTC_3331 9141060 1.957 µM -0.753822601379052 0.201151315383188 no 2711 0.22547787534936 856 4906567 YPR165W RHO1 SGTC_2001 4023502 57.655 µM -0.753862322081889 0.201138387293319 no 2712 0.225465948468219 857 108941 YCR052W RSC6 SGTC_2887 9044784 58.44 µM -0.754047328403373 0.201078178953885 no 2713 0.225410401578626 846 6465546 SGTC_1393 3470-5649 58.2 µM -0.755971267640887 0.200452694336534 no 2714 0.224833211331534 835 4108395 SGTC_741 4582-0002 126 µM -0.756418014275174 0.200307621584979 no 2715 0.224699305350989 861 2912688 SGTC_3015 9080845 49.47 µM -0.756629681678698 0.200238908519543 no 2716 0.224635876838056 852 5296973 SGTC_1327 1436-0082 2.18 µM -0.75672169729183 0.200209042136399 no 2717 0.224608306494458 863 15992205 SGTC_1960 st011366 51.8 µM -0.759044963856506 0.19945584482095 no 2718 0.223912829956962 861 3972846 SGTC_1022 4477-0945 21.3 µM -0.759228864550261 0.199396297609967 no 2719 0.223857831070273 834 4648966 SGTC_1056 3448-1962 115 µM -0.760407823291187 0.199014804019715 no 2720 0.223505424200053 864 715507 SGTC_2449 5812982 45.77 µM -0.761636199533941 0.198617787867029 no 2721 0.223138581686418 860 776185 SGTC_1493 4348-0038 111 µM -0.762246000564671 0.198420875265024 no 2722 0.222956597996877 874 800424 SGTC_568 1193-0097 7.48 µM -0.763162579102604 0.198125121938538 no 2723 0.222683221407682 829 3646150 SGTC_123 0083-0120 66.675 µM -0.763650107665377 0.197967919097599 no 2724 0.222537890143234 876 16001701 SGTC_426 0988-0037 14.6 µM -0.764960489163538 0.197545762112926 no 2725 0.222147536253903 860 5383008 SGTC_174 3553-0389 74.3 µM -0.766969074121569 0.196899726965186 no 2726 0.221549951497115 850 738071 SGTC_2486 5283202 22.39 µM -0.766998019982458 0.196890426265878 no 2727 0.221541346382016 854 1377751 SGTC_1929 genistein trimethyl ether 50.5 µM -0.768168771726872 0.196514470762288 no 2728 0.221193461840804 846 136420 SGTC_1113 artemisinin 1.17947 µM -0.768503391898433 0.196407096457574 no 2729 0.22109408815285 858 2240 An anti-malaria and mitochondrial poison. SGTC_1196 1588-0294 184 µM -0.769050578879207 0.196231589469921 no 2730 0.220931642580117 865 6144269 SGTC_3192 9110362 49.47 µM -0.769778424874402 0.19599828459252 no 2731 0.220715669968689 879 16649480 SGTC_2336 9001819 198.65 µM -0.770754148066711 0.195685788896496 no 2732 0.22042633493396 855 2989602 SGTC_814 3342-0569 96 µM -0.770916907727833 0.195633691171558 no 2733 0.220378092336192 856 4346283 SGTC_2675 theaflavin digallate 100 µM -0.771001793785148 0.195606523342807 no 2734 0.220352934179608 865 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_329 k048-0121 21.3 µM -0.771099845957585 0.195575144543145 no 2735 0.22032387595704 870 6832902 SGTC_653 0203-0016 55.2 µM -0.771427765140489 0.195470225572403 no 2736 0.220226711524849 866 295302 SGTC_1986 st071812 45 µM -0.77208508642007 0.195260016133758 no 2737 0.220032017275083 862 11838594 SGTC_90 0870-0863 4.608 µM -0.772260291741956 0.195204009174332 no 2738 0.219980139281241 872 1738164 SGTC_2416 tofa 880 nM -0.77230246808156 0.195190528344771 no 2739 0.219967651987923 859 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2572 astragaloside iv 100 µM -0.774898487221045 0.194361851900485 no 2740 0.219199823062477 863 45006101 An anti-inflammatory agent. SGTC_582 0987-0078 156 µM -0.774912371274913 0.194357425731698 no 2741 0.219195720699135 880 1625765 SGTC_2188 6126565 140.678 µM -0.776043027066162 0.193997184188655 no 2742 0.218861790594267 845 874518 SGTC_1333 1482-0047 286 µM -0.778744835729542 0.193138002227082 no 2743 0.218065019532762 883 3811116 SGTC_1413 3910-0535 34.4 µM -0.782002020534875 0.192105303087452 no 2744 0.21710669307032 851 2876951 SGTC_369 0957-0393 4.5 µM -0.782613232781136 0.191911893766736 no 2745 0.216927134199829 870 6997992 SGTC_1790 st045711 43.5 µM -0.783183038789488 0.191731694250112 no 2746 0.21675981678722 823 585119 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.784105200039537 0.191440283016319 no 2747 0.216489192219874 881 364106 SGTC_1224 0823-0416 294 µM -0.784715763905825 0.191247488768033 no 2748 0.216310119055855 858 3598164 SGTC_3350 9150499 3.57 µM -0.78491642083402 0.191184154475177 no 2749 0.216251286819523 869 4910996 YPR165W RHO1 SGTC_1777 st045864 34.765 µM -0.785020333285723 0.191151361152277 no 2750 0.216220823524282 896 4691462 SGTC_3104 9120930 49.47 µM -0.785176129428573 0.191102200521114 no 2751 0.216175154501662 864 17014836 SGTC_2656 pseudo-anisatin 100 µM -0.785925764248368 0.190865765719229 no 2752 0.215955489757517 895 6708809 A neurotoxin. SGTC_2698 st077697 67.5 µM -0.786089480698735 0.190814153442381 no 2753 0.215907533300902 865 3154499 SGTC_2838 9002687 71.43 µM -0.78658761351422 0.190657167721015 no 2754 0.215761656265036 877 6457060 SGTC_1563 conessine 56.1 µM -0.786898911016991 0.19055910309724 no 2755 0.215670522530282 869 441082 An anti-amoebic, histamine inhibitor. SGTC_1849 st056239 19.2 µM -0.786910259565448 0.190555528674129 no 2756 0.2156672006137 848 5393181 SGTC_2243 6634756 200 µM -0.786989490734847 0.190530574583435 no 2757 0.215644009105446 845 885676 SGTC_847 0342-0274 5.54 µM -0.788236122270286 0.19013820847671 no 2758 0.215279301884633 875 18097 SGTC_2597 laccaic acid a 100 µM -0.788878806987005 0.189936123329092 no 2759 0.215091421727959 885 5491415 A textile dye. SGTC_2720 fluspirilene 36.88 µM -0.788941092965312 0.189916545208441 no 2760 0.215073218328769 883 3396 An atypical antipsychotic. SGTC_2816 7982706 58.44 µM -0.789050836538014 0.189882052936967 no 2761 0.215041147378718 877 2981853 SGTC_1131 3454-3128 32.3 µM -0.789567097500253 0.189719844426419 no 2762 0.214890314943769 853 710982 SGTC_2546 rhodinyl acetate 100 µM -0.789914064410475 0.189610875784405 no 2763 0.214788978532351 863 6708682 SGTC_3019 9081971 49.47 µM -0.790634865666192 0.189384623608332 no 2764 0.214578547483191 874 16451803 SGTC_2565 isoliquiritigenin 100 µM -0.79161407170927 0.189077527129048 no 2765 0.214292869691698 839 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2028 5153890 36.43 µM -0.792211334299004 0.188890365604043 no 2766 0.21411873040763 874 2830968 YPR165W RHO1 SGTC_2306 7482397 179.52 µM -0.792563534342965 0.188780051763587 no 2767 0.214016080744398 905 891448 SGTC_829 1635-0120 117 µM -0.793603419301518 0.188454577405507 no 2768 0.213713170627162 862 285054 SGTC_1266 0828-0227 32.9 µM -0.794697680361782 0.188112457774903 no 2769 0.213394691007612 893 3913820 SGTC_1524 corynanthine 62.1 µM -0.79649638307336 0.187550928702287 no 2770 0.212871788484123 902 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_574 1315-0397 40 µM -0.796698798588518 0.187487802397885 no 2771 0.212812990933633 880 6794277 SGTC_3292 9120825 59.784 µM -0.796720648732601 0.187480988889129 no 2772 0.212806644482432 862 24824900 SGTC_547 1120-0019 610 nM -0.796766707214569 0.187466627019659 no 2773 0.212793266996244 844 3676939 SGTC_3130 9127414 49.47 µM -0.797154150291917 0.187345842164913 no 2774 0.212680755270748 874 1494646 SGTC_2240 6690706 185.951 µM -0.797336995351746 0.187288857178427 no 2775 0.212627669955488 865 805876 SGTC_1226 3909-7979 35.4 µM -0.799366350220962 0.186657113776293 no 2776 0.212039008093226 874 6615510 SGTC_2877 9040724 71.43 µM -0.799896790841006 0.186492203984482 no 2777 0.211885298639239 885 6463895 SGTC_379 3970-0972 5.9 µM -0.802158494246515 0.185790071405317 no 2778 0.211230641088267 875 2898042 YBL034C STU1 SGTC_2029 5175081 200 µM -0.80220124135691 0.185776816622871 no 2779 0.211218279217507 867 1380876 SGTC_890 0929-0006 47.2 µM -0.802458640244853 0.185697016230408 no 2780 0.211143851994639 879 1378169 SGTC_2057 5236571 38.335 µM -0.804752177522681 0.18498689892085 no 2781 0.210481351615494 879 54684039 YBR257W POP4 SGTC_2459 5811157 9.22 µM -0.805121374711957 0.184872747191178 no 2782 0.210374821177443 870 2870684 YBR192W RIM2 SGTC_842 0271-0008 11.1 µM -0.805355255271056 0.184800456537764 no 2783 0.21030735221693 856 1221709 SGTC_1349 flufenamic acid 69 µM -0.80773878063521 0.184064729784189 no 2784 0.2096204868819 876 3371 A non-steroidal anti-inflammatory. SGTC_57 miconazole 162.5 nM -0.807874491247799 0.184022894703518 no 2785 0.209581418618641 851 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1075 aripiprazole 15.2 µM -0.807949233468454 0.183999856684184 no 2786 0.209559903716597 871 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2568 diosmetin 100 µM -0.81303702176854 0.182435855976311 no 2787 0.208098416206968 871 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1673 st016611 27.3 µM -0.813651764738099 0.1822474461835 no 2788 0.207922237095699 893 5226799 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.813909501143444 0.182168489910449 no 2789 0.207848398661509 872 1609 A potent and irreversible inhibitor of serine proteases. SGTC_234 nsc-17383 10.7 µM -0.816572343338552 0.18135399340456 no 2790 0.207086432754824 847 408974 SGTC_1292 0kpi-0043 232 µM -0.817420495902349 0.181095044391797 no 2791 0.206844083372949 868 3333905 SGTC_775 4577-0580 57.3 µM -0.817459512158421 0.181083137934723 no 2792 0.20683293898812 883 2006902 SGTC_2658 polymyxin b sulfate 77.05 µM -0.817864917294616 0.180959450863597 no 2793 0.206717162371096 882 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2451 5856223 45.7 µM -0.818226021966521 0.180849324232984 no 2794 0.206614069511043 876 2179896 SGTC_3288 9119690 36.221 µM -0.820792061312218 0.180067965730669 no 2795 0.205882360637902 896 17595618 YKL019W RAM2 SGTC_1696 st025591 34.7925 µM -0.823003538988045 0.179396274297254 no 2796 0.205252990457054 864 2787147 SGTC_189 3970-0742 2.116 µM -0.823875085187247 0.179131993140885 no 2797 0.20500526919247 863 2891807 SGTC_3129 9127257 49.47 µM -0.824058090616621 0.179076531069986 no 2798 0.204953275790857 892 837894 SGTC_1328 1441-0025 69.2 µM -0.824120264367796 0.17905769100051 no 2799 0.204935613482735 881 4562601 SGTC_913 3487-1245 167 µM -0.825168642236069 0.178740196334444 no 2800 0.204637926787198 873 4016153 SGTC_2762 leflunomide 42.06 µM -0.82519167454776 0.178733225124396 no 2801 0.204631389656055 891 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1770 st043884 66.3 µM -0.825611345510062 0.1786062329215 no 2802 0.204512298571206 906 670149 SGTC_2980 9014342 25.29 µM -0.827352809361719 0.17807987423471 no 2803 0.204018559862672 860 2996599 SGTC_3023 9089636 49.47 µM -0.827379334896402 0.178071864441755 no 2804 0.204011044855331 900 17249241 SGTC_2322 7413319 38.22 µM -0.828539410816163 0.177721783888418 no 2805 0.203682542562486 865 1840400 SGTC_2575 plumbagin 510 nM -0.829332441106112 0.177482718151388 no 2806 0.203458159320538 871 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2977 9011197 71.43 µM -0.830506979884488 0.177129016588005 no 2807 0.203126101568255 867 2704722 SGTC_1295 1013-0063 9.78 µM -0.830600653866188 0.177100826713848 no 2808 0.203099632624304 888 6826038 SGTC_1442 4112-3290 3 µM -0.831862285972611 0.176721432358061 no 2809 0.202743340826346 895 704353 SGTC_1440 4100-1550 40 µM -0.83298922493759 0.176382977359308 no 2810 0.202425403115142 881 742806 SGTC_3057 9095946 49.47 µM -0.835152038064193 0.175734566633753 no 2811 0.201816055120024 890 24540043 SGTC_1925 st057770 10.1 µM -0.835539425157911 0.175618587760038 no 2812 0.201707029308787 892 5989122 SGTC_3229 9132204 49.47 µM -0.836546909714024 0.175317186586901 no 2813 0.201423649145333 896 17682924 SGTC_186 3455-3465 67.277 µM -0.836926594010918 0.175203684588187 no 2814 0.201316915399271 870 755278 SGTC_1919 st067113 52.3 µM -0.838818529629123 0.174638808364466 no 2815 0.200785575500026 896 1268243 SGTC_133 0724-0033 378.92 µM -0.839294400102913 0.174496909675896 no 2816 0.200652062441237 881 280309 SGTC_1915 st067105 30.6 µM -0.839332982183161 0.174485408187 no 2817 0.200641239959021 877 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1052 3253-3998 198 µM -0.840293878259454 0.174199116151438 no 2818 0.200371816478549 890 5450317 SGTC_2170 morpholine 200 µM -0.841382489966379 0.173875133074827 no 2819 0.200066845833434 885 121171 Reacts with secondary amines. SGTC_2777 climbazole 1.536 µM -0.84232510736207 0.173594909310086 no 2820 0.199803000515061 889 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1515 3460-0031 42.1 µM -0.842342901670585 0.173589622136661 no 2821 0.199798021775101 875 2876596 SGTC_18 0111-0177 500 nM -0.842526040683989 0.173535212505078 no 2822 0.199746784922636 896 721752 SGTC_2853 9015042 58.44 µM -0.843176372934167 0.173342089945233 no 2823 0.199564905169858 876 6457456 SGTC_1038 k292-0204 154 µM -0.843200985925733 0.173334783563503 no 2824 0.199558023562115 883 4454212 SGTC_363 0455-0021 3.06 µM -0.843398771470427 0.173276077920968 no 2825 0.199502729393127 874 4597466 SGTC_1028 k015-0029 4.8 µM -0.844056291152552 0.173081007475513 no 2826 0.199318975360071 879 4588309 SGTC_1287 0971-0001 34.6 µM -0.845656507460916 0.172606846128073 no 2827 0.198872196228202 869 4665869 SGTC_2342 7990637 118.86 µM -0.84721973036566 0.17214444685829 no 2828 0.198436329020702 912 2033102 YER133W GLC7 SGTC_2453 5731132 22.18 µM -0.847701830560263 0.172002001907401 no 2829 0.198302023321105 907 1362040 SGTC_2134 5324836 1.464 µM -0.847726287692725 0.171994777625075 no 2830 0.19829521140264 901 699272 SGTC_2529 gangaleoidin 93.61 µM -0.847800051797392 0.171972989951253 no 2831 0.198274667123859 886 4565183 SGTC_2993 9054257 71.4286 µM -0.847833082587051 0.171963234231446 no 2832 0.198265468028511 874 6470217 YGL055W OLE1 SGTC_868 0527-0199 213 µM -0.848666063962373 0.171717328078318 no 2833 0.19803356737258 886 2849450 SGTC_127 0180-0333 59.125 µM -0.849059104819125 0.171601375711204 no 2834 0.19792420234227 835 771601 SGTC_1635 st007035 42.4 µM -0.850010085416221 0.171321030580514 no 2835 0.19765973954143 865 3716403 SGTC_1857 st056007 79.3 µM -0.851453466385615 0.170896087648952 no 2836 0.197258751060299 877 619834 SGTC_1922 5578187 25 µM -0.852945644172325 0.170457488166732 no 2837 0.196844724000283 839 1350412 SGTC_1085 doxorubicin 7.67 µM -0.853093994631178 0.170413922583265 no 2838 0.196803590721354 878 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_596 1155-0152 116 µM -0.853348903946828 0.170339080872428 no 2839 0.196732923919269 884 280313 SGTC_678 1218-2179 85.9 µM -0.853479124960619 0.170300855937638 no 2840 0.19669682955136 907 6820081 YOR116C RPO31 SGTC_714 4296-0578 26.1 µM -0.855611800436574 0.169675614754149 no 2841 0.196106270280724 890 1589775 SGTC_2912 7964298 10.93 µM -0.858270758056761 0.168898147270389 no 2842 0.195371486218347 884 2975850 SGTC_364 0083-0097 67.7 µM -0.860299534706243 0.168306483705311 no 2843 0.194811974654798 910 5207356 SGTC_1386 3228-0095 33.8 µM -0.860965434104544 0.168112574660158 no 2844 0.194628540471152 895 870181 SGTC_1516 st013856 110 µM -0.861302968926446 0.168014339878065 no 2845 0.194535600474276 900 5281404 A mutagen and neurotoxin. SGTC_263 alizarin 107.927 µM -0.864659029664636 0.167039615779104 no 2846 0.193612981432431 911 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2135 5326629 150.42 µM -0.865531824155012 0.166786722665661 no 2847 0.193373478291358 901 5020077 SGTC_3175 9106517 49.47 µM -0.865853301098814 0.166693636667609 no 2848 0.193285307522797 897 41468073 SGTC_1361 1608-0041 5.61 µM -0.866442401491062 0.166523145367309 no 2849 0.193123799950734 883 X1361 SGTC_1410 3909-8106 77.9 µM -0.866662974722701 0.166459338333339 no 2850 0.193063348870808 883 1039210 SGTC_2072 5231554 129 µM -0.867021926285742 0.166355535209532 no 2851 0.192964998038653 892 789545 SGTC_1713 st033146 12.748 µM -0.867072701943768 0.166340855066305 no 2852 0.192951088247226 898 674619 SGTC_2044 5102272 200 µM -0.8670848723556 0.166337336508697 no 2853 0.192947754301846 889 592666 SGTC_1485 3909-9022 254 µM -0.86877537446949 0.165849066643531 no 2854 0.192485002446676 916 714516 SGTC_2624 nerol 100 µM -0.87313755927669 0.164593415720525 no 2855 0.191294051948581 904 637566 A natural product oil. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.877242913654976 0.163417335283224 no 2856 0.190177355870877 919 688801 SGTC_2299 7976368 114.88 µM -0.877427150959876 0.163364684234282 no 2857 0.190127335631342 903 2979718 SGTC_358 0075-0058 9.45 µM -0.879463678118871 0.162783422921297 no 2858 0.18957495933114 934 1069125 SGTC_472 calcifediol 10 µM -0.880655339754602 0.162443925915518 no 2859 0.189252198035087 904 5283731 A vitamin D metabolite. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.881158346083471 0.162300760935363 no 2860 0.189116060483444 875 688667 SGTC_21 0849-0113 22.993 µM -0.882875040175565 0.16181277649931 no 2861 0.188651895342139 878 1560156 SGTC_3038 9091290 49.47 µM -0.883660822106523 0.161589730804281 no 2862 0.188439667663454 885 25236843 SGTC_2885 9057732 51.95 µM -0.883729461976852 0.161570256769622 no 2863 0.188421136080175 884 6471414 SGTC_809 3998-0021 90 µM -0.884791111042279 0.161269247808065 no 2864 0.188134652268809 910 715485 SGTC_701 4424-0219 185 µM -0.886013948655001 0.16092299074659 no 2865 0.187805005401494 899 2911779 SGTC_1718 roemerine 11.9335 µM -0.887227011687303 0.160579981283507 no 2866 0.187478346213996 859 235224 An aporphine alkaloid with mutagenic activity. SGTC_851 0394-0702 453 µM -0.887293356783828 0.160561235122522 no 2867 0.187460490635068 909 762646 SGTC_3341 9147222 25.867 µM -0.887499620070303 0.160502963461674 no 2868 0.187404985327669 891 1939759 SGTC_1262 0737-0114 49.6 µM -0.888831596518528 0.160126998105146 no 2869 0.187046796053051 914 765919 SGTC_2014 4013930 200 µM -0.890671852285373 0.159608513212398 no 2870 0.186552619812149 908 64556 SGTC_256 clotrimazole 625 nM -0.891806957816703 0.159289250131278 no 2871 0.186248205841103 855 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_382 3229-0966 23.2 µM -0.89230272673622 0.159149940031261 no 2872 0.186115346567613 910 5722370 SGTC_1482 3346-2049 8.48 µM -0.892922759088124 0.15897582450391 no 2873 0.185949269097602 893 3826804 SGTC_2113 5491891 107.031 µM -0.893560032511075 0.158796997517809 no 2874 0.185778669348109 895 789979 SGTC_2856 9022925 19.48 µM -0.895956300542109 0.158125754919759 no 2875 0.185138051467017 903 4944862 SGTC_1596 piperlongumine 63 µM -0.897042654981994 0.157822059740729 no 2876 0.184848078233798 897 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_705 1124-0212 310 µM -0.89794946741169 0.157568849850701 no 2877 0.184606245211875 892 9554485 SGTC_300 r073-0011 5.04 µM -0.898048892451387 0.157541103572326 no 2878 0.184579742045983 896 2735780 SGTC_2423 st077119 87.2 µM -0.89806623282085 0.157536264770884 no 2879 0.184575119964912 883 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_709 3807-1509 243 µM -0.899481655467426 0.157141622758289 no 2880 0.184198081351498 929 1886677 YPL242C IQG1 SGTC_1707 st032323 6.317 µM -0.901292748408041 0.156637610630447 no 2881 0.183716344188258 894 3132057 YMR211W DML1 SGTC_1722 st034304 3.6505 µM -0.902399744141756 0.156330067485321 no 2882 0.183422278488749 923 4036148 YLR033W RSC58 SGTC_15 0266-0086 27.098 µM -0.904515844257755 0.155743284694261 no 2883 0.182860968372198 924 1712902 YIL048W NEO1 SGTC_2480 5767542 37.17 µM -0.904916678737106 0.155632299345095 no 2884 0.182754765167855 889 2867358 SGTC_2485 5633444 17.78 µM -0.905277646920394 0.155532397056081 no 2885 0.18265915770807 895 5724239 SGTC_1182 1222-0449 220 µM -0.905860915980736 0.15537105975097 no 2886 0.182504736776988 902 658318 SGTC_2214 7179297 48.276 µM -0.907129215784347 0.155020618275736 no 2887 0.182169234968159 905 769744 SGTC_852 0418-0143 439 µM -0.907501834617572 0.154917759961125 no 2888 0.182070739874443 881 5369229 SGTC_742 0kpi-0133 140 µM -0.907898450798941 0.154808326914721 no 2889 0.181965938099671 907 2728852 SGTC_2352 9027995 87.8 µM -0.908277157543811 0.154703883054227 no 2890 0.181865903924328 905 2997347 SGTC_3050 9093513 49.47 µM -0.91058783014077 0.154067629577766 no 2891 0.181256292572146 894 25236664 SGTC_235 0330-0087 5 mM -0.911266634815685 0.153881047284709 no 2892 0.181077450940922 911 46494818 YHR062C RPP1 SGTC_1651 st011928 86.1 µM -0.911579251970227 0.153795168866617 no 2893 0.180995124291077 920 720198 SGTC_618 k072-0232 33.2 µM -0.912664673035779 0.153497241404881 no 2894 0.180709464520059 893 5872756 YGL099W LSG1 SGTC_674 0498-0004 451 µM -0.912728468493791 0.153479742664855 no 2895 0.180692683710448 890 4231473 SGTC_1952 st077036 64.1 µM -0.913623323547192 0.15323442814167 no 2896 0.180457403284092 903 2937007 SGTC_3110 9122132 49.47 µM -0.914092151433766 0.153106007987393 no 2897 0.180334213120787 894 918317 SGTC_2622 2-methoxyxanthone 59.94 µM -0.91410118281755 0.153103534834003 no 2898 0.180331840534294 912 71034 A hepatoprotective. SGTC_719 2810-4230 27.3 µM -0.914117314383858 0.153099117433103 no 2899 0.180327602745594 909 721079 SGTC_3055 9094636 49.47 µM -0.914561633891674 0.152977480037965 no 2900 0.180210903853655 914 25236176 SGTC_2850 9015429 58.44 µM -0.915273384715799 0.152782763907657 no 2901 0.18002406391207 919 6457570 SGTC_1763 st044482 94.5 µM -0.9152747426753 0.152782392563162 no 2902 0.180023707553784 901 88505 SGTC_1688 st021091 57.6 µM -0.915819571791646 0.152633453138916 no 2903 0.179880768211028 929 3656366 SGTC_960 1222-0186 7.7 µM -0.917041823424598 0.152299677891238 no 2904 0.179560362229952 917 3126296 SGTC_1831 st055328 12 µM -0.917901447616891 0.152065220205921 no 2905 0.179335231857174 903 1103068 SGTC_1077 5-fluorocytosine 377 nM -0.920599085780888 0.151331011709651 no 2906 0.178629889845242 922 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2293 7624732 200 µM -0.920982986844033 0.151226718404282 no 2907 0.178529654760858 896 894453 SGTC_2594 a-mangostin 100 µM -0.921215373478252 0.151163609827588 no 2908 0.178468996724651 916 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_715 0868-0130 184 µM -0.922394788095147 0.15084358970304 no 2909 0.178161343682467 941 2876258 SGTC_647 0140-0236 81 µM -0.922529446777372 0.15080708037916 no 2910 0.1781262389277 917 990837 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.924501256568297 0.15027314740653 no 2911 0.177612698777204 927 61125 An anti-inflammatory. SGTC_1321 1326-2144 215 µM -0.924865170097907 0.150174743613659 no 2912 0.177518022995838 925 3513030 SGTC_209 4077-0173 175.592 µM -0.92685893749131 0.149636382690268 no 2913 0.176999889738732 900 15993494 SGTC_2585 alliin 100 µM -0.927215994871022 0.149540105496204 no 2914 0.176907199911259 902 87310 A garlic compound which reacts with lipids. SGTC_386 1509-0011 3.07 µM -0.928569375291107 0.149175554464636 no 2915 0.176556149513977 908 3107280 SGTC_2534 helenine 20.12 µM -0.929280196421916 0.148984323249646 no 2916 0.176371947757576 890 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2931 9014674 55.67 µM -0.929536890163556 0.14891530555907 no 2917 0.176305458190201 922 2996810 SGTC_2446 5162541 200 µM -0.930721792629491 0.148596995720364 no 2918 0.175998746892737 916 1549321 SGTC_1427 4048-4900 550 nM -0.932178784377708 0.148206216364687 no 2919 0.175622068867627 904 24132586 SGTC_2216 7189485 200 µM -0.935067706147762 0.147433414400982 no 2920 0.174876703994061 894 731273 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.939000351453597 0.14638575772669 no 2921 0.173865281947093 905 688803 SGTC_804 1595-0054 20.9 µM -0.93988825128377 0.146149914559677 no 2922 0.173637442181815 919 761523 Stimulates phospholipase C. SGTC_86 0417-1630 471.922 µM -0.94097439303022 0.14586176178956 no 2923 0.173358990948613 899 3634867 SGTC_1000 4048-0884 8.67 µM -0.941234397314876 0.14579283948356 no 2924 0.173292376544276 931 13040088 SGTC_1746 st038117 42 µM -0.941956059286194 0.145601655012346 no 2925 0.173107568530502 901 2898218 SGTC_2875 9039966 71.43 µM -0.942983830742835 0.145329666377664 no 2926 0.172844586746848 924 6463691 SGTC_1190 1486-1332 13 µM -0.945119889213618 0.14476547556214 no 2927 0.172298836164428 902 4150046 SGTC_1016 4226-1401 38 µM -0.94549305459875 0.144667064048137 no 2928 0.17220360749781 902 2901613 SGTC_499 genistein 192 µM -0.947028303544587 0.144262660945543 no 2929 0.171812178301509 939 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3141 9094609 49.47 µM -0.94796299036786 0.144016826708493 no 2930 0.171574147760886 924 25236309 YDL196W YDL196W SGTC_995 3931-2021 34.6 µM -0.949703536963262 0.143559794640599 no 2931 0.1711314560342 938 730143 SGTC_482 fipronil 114 µM -0.95034312285449 0.143392098652741 no 2932 0.170968967047808 900 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2981 9013952 38.96 µM -0.95172226893669 0.143030944206434 no 2933 0.170618926264824 907 2996344 SGTC_813 k007-0158 173 µM -0.951782266987883 0.143015246589775 no 2934 0.170603708593213 900 6523916 SGTC_1870 st057514 26.5 µM -0.952717000994907 0.142770837381858 no 2935 0.170366738537717 917 5393161 SGTC_1575 cyproterone acetate 48 µM -0.953249982010679 0.142631602851333 no 2936 0.170231713732486 933 9880 An androgen receptor antagonist and liver toxin. SGTC_3077 9117319 49.47 µM -0.954303604456296 0.142356627582669 no 2937 0.169964992022299 928 17154678 SGTC_1608 st001473 40.5 µM -0.956844934900772 0.14169486557105 no 2938 0.169322764028678 929 7292267 SGTC_2790 5423970 71.43 µM -0.957743977319658 0.141461254851465 no 2939 0.169095937543206 920 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.960864623481027 0.14065240000312 no 2940 0.16831012016167 918 688761 SGTC_2224 6650123 117.647 µM -0.960966191036796 0.140626127083407 no 2941 0.168284583722786 933 2908370 SGTC_1714 st033236 13.627 µM -0.962232417649291 0.140298866367723 no 2942 0.167966434210661 929 2916566 SGTC_2104 5389443 200 µM -0.966686247313082 0.139151869966175 no 2943 0.166850452102448 935 2244536 SGTC_3355 9151058 44.0485 µM -0.967304474171674 0.138993163638633 no 2944 0.166695923852511 911 17015728 SGTC_200 k038-0079 37.545 µM -0.969373597249973 0.138462891309402 no 2945 0.166179410378964 950 3436683 SGTC_2425 5628681 7.85 µM -0.969450294165595 0.138443262051824 no 2946 0.166160284483494 922 5714958 SGTC_555 4296-0685 37 µM -0.9695440389254 0.138419272267165 no 2947 0.166136909301601 921 2908540 YHR072W ERG7 SGTC_447 ml7 120 µM -0.972176193535481 0.137746846255371 no 2948 0.165481450926154 936 4216 Selective myosin light chain kinase inhibitor. SGTC_26 0302-0163 425.158 µM -0.975517669763737 0.136896428506343 no 2949 0.164651770587489 956 3100915 SGTC_2455 5377712 9.75 µM -0.97743997869764 0.136408823255834 no 2950 0.164175689436578 887 2243908 SGTC_3099 9120367 49.47 µM -0.978874925680855 0.136045615651355 no 2951 0.16382089142557 924 24824940 SGTC_2826 7992541 19.48 µM -0.979862701006899 0.13579597924996 no 2952 0.163576948302009 968 2985066 SGTC_3088 9117578 49.47 µM -0.980038593680055 0.135751559542864 no 2953 0.163533534221311 952 678341 SGTC_305 1682-2595 20.8 µM -0.981211605845253 0.135455583064006 no 2954 0.163244201042749 915 226033 SGTC_2160 5660466 132.927 µM -0.982282052874342 0.135185872180181 no 2955 0.162980456848825 946 2859134 SGTC_2482 5981709 142.65 µM -0.98447039518761 0.134635641698669 no 2956 0.162442140356532 938 877755 SGTC_2090 5301565 104.445 µM -0.984487662471882 0.134631306183288 no 2957 0.162437897335105 932 2056344 SGTC_3053 9095903 49.47 µM -0.986890759449914 0.134028864683402 no 2958 0.161848097367389 963 17174018 SGTC_208 k072-0098 12.366 µM -0.987007554820298 0.133999632082776 no 2959 0.161819467497346 942 5948901 SGTC_2792 7535235 81.82 µM -0.990644872097262 0.133091443701925 no 2960 0.160929509300832 925 1281891 SGTC_2975 9084847 53.72 µM -0.991441801777189 0.132893028389274 no 2961 0.160734948549121 924 27211724 SGTC_1317 1273-0028 910 nM -0.992361285609641 0.132664353369138 no 2962 0.16051065860888 908 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1013 4112-3890 241 µM -0.992645137760553 0.132593814311903 no 2963 0.160441459799196 925 705171 SGTC_1656 st012921 11 µM -0.993048201591115 0.132493694798943 no 2964 0.160343232502236 901 6732821 SGTC_1107 amlodipine 47 µM -0.997139410402789 0.131480401711663 no 2965 0.159348422887429 847 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3311 9131146 2.8755 µM -0.999103376158994 0.130995880389728 no 2966 0.158872307916157 924 4900406 YPR165W RHO1 SGTC_1504 k297-0033 30 µM -0.999664164808222 0.13085775740852 no 2967 0.158736529861498 878 4388117 SGTC_1252 0493-0875 34.8 µM -0.999862465315341 0.130808939830188 no 2968 0.158688535587284 918 3960963 SGTC_2064 5220758 200 µM -1.00057637702556 0.130633293430682 no 2969 0.158515827757588 927 788518 SGTC_997 3996-0078 137 µM -1.00057821927265 0.130632840386701 no 2970 0.158515382245068 929 735687 SGTC_928 2764-0428 58.7 µM -1.0022474811065 0.130222783171633 no 2971 0.158112040417051 943 662578 SGTC_613 3914-0030 117 µM -1.00709949949808 0.129035936090272 no 2972 0.156943480855314 894 1145395 SGTC_2242 6630449 61.2675 µM -1.00776282137052 0.128874266296697 no 2973 0.15678416909379 941 691249 YDR170C SEC7 SGTC_1199 1638-0010 4.46 µM -1.01071169420127 0.12815724578279 no 2974 0.156077219167822 920 3111136 SGTC_1757 st041620 31.8375 µM -1.0129236688306 0.127621224457385 no 2975 0.15554831098236 965 5289815 SGTC_2314 7727897 200 µM -1.01399684741594 0.127361726548905 no 2976 0.155292128302032 892 900724 SGTC_3223 9129970 49.47 µM -1.01448105733599 0.127244763320174 no 2977 0.155176631865999 944 17248386 SGTC_1774 st048371 48.465 µM -1.01484316918917 0.127157342316825 no 2978 0.155090296008013 948 4242727 SGTC_2869 9037858 32.47 µM -1.01586498237877 0.126910881663736 no 2979 0.154846843110716 919 27187042 SGTC_2270 7924575 90.91 µM -1.01809708931606 0.126373656098957 no 2980 0.154315909230779 931 1262135 SGTC_666 0272-0154 136 µM -1.0190995515752 0.126132898913649 no 2981 0.154077853523403 944 6870312 SGTC_395 anisomycin 6.25 µM -1.02053006836007 0.125789891627887 no 2982 0.153738568207618 946 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3046 9092212 49.47 µM -1.02066792226564 0.125756871617766 no 2983 0.153705898614173 962 25236637 SGTC_2233 sulbentine 40.3845 µM -1.0218772887876 0.125467452430591 no 2984 0.153419491416031 912 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2250 alverine citrate 130 µM -1.02347564045501 0.125085657054754 no 2985 0.153041505828993 906 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3005 9076496 71.4286 µM -1.02479812682803 0.124770371140243 no 2986 0.152729225226101 928 21368410 SGTC_698 k064-0052 127 µM -1.02580690188194 0.124530248893092 no 2987 0.152491306078056 982 5088751 SGTC_2381 9035592 200 µM -1.02709095920994 0.124225067851921 no 2988 0.152188817687563 945 4749657 SGTC_3347 9188721 44.724 µM -1.02727786999114 0.124180688548174 no 2989 0.152144819917457 942 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_307 1501-1223 22.3 µM -1.02736060417889 0.124161048034933 no 2990 0.152125347441663 932 2830329 SGTC_2060 5238662 140 µM -1.02824485077771 0.12395126984938 no 2991 0.151917332850513 951 790130 SGTC_2092 5303694 80.6725 µM -1.03057270711119 0.123400196947458 no 2992 0.151370620193272 933 1963699 SGTC_295 k015-0027 31 µM -1.03089935616706 0.123323006923096 no 2993 0.151294009286356 937 3887424 SGTC_787 4152-0075 138 µM -1.03211660664789 0.123035657958179 no 2994 0.151008747586808 924 9566539 SGTC_1776 st049249 45.9 µM -1.03232516903273 0.122986471033229 no 2995 0.150959907096383 949 1822314 SGTC_1225 1216-0074 20.6 µM -1.03247150706134 0.122951967203694 no 2996 0.150925644389058 941 4241466 SGTC_2830 7992007 71.43 µM -1.03269381834251 0.122899563258944 no 2997 0.150873603665551 933 1952075 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.03347301978113 0.122716010991387 no 2998 0.15069129515011 970 442882 SGTC_2033 5192550 145 µM -1.03577422013361 0.122175052447412 no 2999 0.150153743621271 899 182073 SGTC_1875 nocodazole 6 µM -1.03744405956974 0.121783561839274 no 3000 0.149764476818898 935 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1439 4092-1168 46 µM -1.03899191255646 0.121421458631967 no 3001 0.14940424878403 959 2886240 SGTC_2415 st077333 57.7 µM -1.04078269278981 0.121003470532557 no 3002 0.148988207138394 912 2766255 SGTC_524 r073-0010 27.8 µM -1.04168191154484 0.120793965078844 no 3003 0.148779589008198 945 2772106 SGTC_508 roscovitine 141 µM -1.04242248246596 0.120621614182782 no 3004 0.148607923737198 956 160355 A CDKinase inhibitor. SGTC_407 eburnamonine 100 µM -1.04290446170292 0.120509537621394 no 3005 0.14849627150779 912 3195 SGTC_2458 5808907 16.39 µM -1.04717045255417 0.11952074608283 no 3006 0.147510485157657 935 2731747 SGTC_68 0986-0284 82.829 µM -1.04728549962557 0.119494159419922 no 3007 0.147483960902295 915 423278 YIL048W NEO1 SGTC_194 1486-1323 56.904 µM -1.04779946396577 0.119375436411988 no 3008 0.1473655047667 941 5178754 SGTC_2386 9075165 157.42 µM -1.05563672848755 0.117575375190276 no 3009 0.145567107030677 939 16452277 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.05580233704995 0.117537546688729 no 3010 0.145529265146093 960 6708561 SGTC_2005 4024620 188 µM -1.06457004587043 0.115547107003998 no 3011 0.143535270465209 953 236743 SGTC_1414 3917-0015 5.4 µM -1.0651226937307 0.115422452459309 no 3012 0.143410205466622 942 6618702 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.06898979098218 0.114552868546358 no 3013 0.14253713481579 952 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2512 diallyl trisulfide 49.23 µM -1.06945095887245 0.114449478967327 no 3014 0.14243325781372 980 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_391 gliotoxin 8.33 µM -1.07254819863043 0.113756827438785 no 3015 0.141736938687519 956 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_8 0354-0001 70 µM -1.07293279547808 0.113671027069412 no 3016 0.141650635112959 943 4993152 SGTC_3353 9151644 39.2805 µM -1.07997949545652 0.112107126537901 no 3017 0.140075655547666 944 4909158 SGTC_172 1112-0046 2.638 µM -1.08144292147428 0.111784280952309 no 3018 0.139750068883032 981 2802135 YIL048W NEO1 SGTC_2892 9047358 58.44 µM -1.08700395259591 0.110563530912981 no 3019 0.138517531439185 964 6466771 SGTC_963 1269-2853 151 µM -1.08764727767168 0.110422928129723 no 3020 0.138375425457256 961 3668223 SGTC_2472 5377652 49.4 µM -1.09147717803017 0.109588532063586 no 3021 0.137531484342624 977 1610903 SGTC_1621 st003705 32.4 µM -1.09292615876491 0.109274035212448 no 3022 0.137213110948879 950 24207032 SGTC_2806 7952793 58.44 µM -1.09307296191078 0.109242208249086 no 3023 0.137180883130864 943 2972490 SGTC_737 1950-0117 57.9 µM -1.09411955674668 0.109015499177728 no 3024 0.136951273124255 943 5393513 SGTC_1906 st060206 94.7 µM -1.09631979810361 0.108539995124637 no 3025 0.136469424128979 940 5133468 SGTC_1098 clofazimine 15.1 µM -1.09676703536778 0.108443523405682 no 3026 0.13637162193773 966 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_493 zm226600 134 µM -1.09973268957026 0.107805374909394 no 3027 0.13572430366722 949 5240098 A potassium channel opener. YCR052W RSC6 SGTC_802 4112-3352 742 µM -1.10012519704498 0.107721118390793 no 3028 0.135638788375635 928 704594 SGTC_2701 st077767 14.721 µM -1.10176118295623 0.10737044500073 no 3029 0.13528275501288 945 5721188 SGTC_924 2046-0044 21.3 µM -1.10202911882644 0.107313091490069 no 3030 0.135224506260885 941 3623589 SGTC_3217 9129673 49.47 µM -1.10273705152772 0.107161659919379 no 3031 0.13507068577098 967 17248312 SGTC_1627 st003713 25.6 µM -1.10310466121815 0.10708308654279 no 3032 0.134990858434215 961 16195070 YER133W GLC7 SGTC_1308 1187-1617 41.4 µM -1.10428798003642 0.106830444589159 no 3033 0.134734117632348 951 2882570 SGTC_2427 5545055 42.75 µM -1.10506104281603 0.106665625907545 no 3034 0.13456656980532 935 5372858 SGTC_3051 9093778 49.47 µM -1.10623466582134 0.10641575783972 no 3035 0.134312481028837 987 17217378 SGTC_539 4859-0462 2.54 µM -1.10813895064346 0.106011229257123 no 3036 0.133900905732981 941 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_290 2043-6722 48.1 µM -1.10937398379962 0.105749464994454 no 3037 0.133634440407238 944 773758 YLR208W SEC13 SGTC_1304 1165-0502 251 µM -1.11423528261391 0.104723656229226 no 3038 0.132589131364864 951 767425 SGTC_261 5-fluorouridine 15.376 µM -1.11676420032362 0.104192874131275 no 3039 0.132047579737782 964 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2785 7756463 72.73 µM -1.11700502236937 0.104142431054728 no 3040 0.131996088888335 958 2201551 SGTC_573 3702-0553 84.7 µM -1.11776339493476 0.103983696457054 no 3041 0.131834029556539 950 1222756 SGTC_1650 st011916 45.8 µM -1.11822940637119 0.103886242897569 no 3042 0.131734514030893 975 242528 SGTC_848 0368-0089 85.6 µM -1.12082922060493 0.103343778263816 no 3043 0.131180281755156 946 762535 SGTC_91 0417-1751 58.384 µM -1.12205340200423 0.103089059827736 no 3044 0.13091986745377 987 6795624 SGTC_2144 5628481 200 µM -1.12303053923146 0.102886071956886 no 3045 0.130712262224699 937 2818399 SGTC_1641 st009299 47.1 µM -1.12461825689721 0.102556863290808 no 3046 0.130375416953426 938 4046054 SGTC_1949 st076024 69.1 µM -1.12480927015632 0.102517308908678 no 3047 0.13033493267194 964 2921930 SGTC_1112 tnp00069 1.16933 µM -1.12536350411258 0.102402602789147 no 3048 0.130217514852218 956 145826 SGTC_2945 9067681 61.76 µM -1.12545646317485 0.102383372812719 no 3049 0.130197828081817 983 16456930 SGTC_215 1287-0124 461.5 µM -1.12743889586991 0.101973901833884 no 3050 0.129778480835493 973 5560863 SGTC_1995 st072814 61.1 µM -1.13034348497413 0.101376113849542 no 3051 0.12916575896259 973 5769371 SGTC_864 0469-0573 172 µM -1.13142728542677 0.101153714187552 no 3052 0.128937646290211 989 689425 SGTC_2034 5197015 53.07 µM -1.13143351595795 0.101152436689388 no 3053 0.128936335728699 968 780676 SGTC_2049 5262831 67.185 µM -1.13180347323261 0.101076602315781 no 3054 0.128858533600557 951 763417 SGTC_1480 1070-0044 41.2 µM -1.13591824078412 0.100235943429734 no 3055 0.127995391729716 959 3124987 SGTC_2136 5328288 199.296 µM -1.13657458461651 0.100102323827271 no 3056 0.127858084865856 969 262395 SGTC_237 nikkomycin 200 µM -1.13676860994183 0.100062848734505 no 3057 0.127817514455146 982 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3066 9117245 49.47 µM -1.1370889232165 0.0999977048147906 no 3058 0.127750556997438 944 17176980 SGTC_500 h-89 112 µM -1.13820274215962 0.0997714222524243 no 3059 0.127517916963471 966 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_58 0957-0393 9 µM -1.13965972685104 0.099475987413429 no 3060 0.12721404585876 964 6997992 SGTC_841 0251-0215 91.2 µM -1.14225516504349 0.0989512916948838 no 3061 0.126673985857732 960 3888614 SGTC_2810 7959871 45.46 µM -1.14751999161956 0.0978931750359467 no 3062 0.125583387772042 942 2974535 SGTC_2601 securinine 100 µM -1.14762551566253 0.0978720520832304 no 3063 0.125561595864725 964 442872 A GABA receptor antagonist. SGTC_2091 4-phenylthiadiazole 200 µM -1.14948218089036 0.0975009461181052 no 3064 0.125178605124955 965 270010 SGTC_1080 nisoldipine 24.4 µM -1.15181713171544 0.097035707940316 no 3065 0.124698113242372 972 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2687 chenodiol 100 µM -1.15308891103118 0.0967829928314464 no 3066 0.124436946323031 946 5702181 A cholesterol synthesis inhibitor. SGTC_627 1391-0720 175 µM -1.15589282642493 0.096227535243818 no 3067 0.123862498617478 978 997839 SGTC_3352 9151559 45.5865 µM -1.15661822557918 0.0960842154478541 no 3068 0.12371418632805 949 17159339 SGTC_2854 9024559 71.43 µM -1.15705514953349 0.0959979665338446 no 3069 0.123624914579608 967 3163529 SGTC_1180 1193-0155 285 µM -1.16002109717115 0.0954139921260421 no 3070 0.123020108323475 990 2921347 SGTC_1419 3993-2473 62.6 µM -1.16009972649285 0.0953985462208649 no 3071 0.123004102764998 974 704026 SGTC_1042 0350-0096 82 µM -1.1634899571995 0.0947343204103033 no 3072 0.122315385204578 968 3122515 SGTC_845 0330-0138 4.51 µM -1.16623149589935 0.0941996860183001 no 3073 0.121760430812749 957 9039800 SGTC_2804 7954240 19.48 µM -1.16692559486168 0.0940646817853128 no 3074 0.121620209319068 956 828705 SGTC_2097 5376186 200 µM -1.16728054529743 0.0939956981044813 no 3075 0.121548546299909 964 742755 SGTC_663 1486-0733 13.9 µM -1.17082726189042 0.0933084522433099 no 3076 0.120834108674491 971 722445 YPR165W RHO1 SGTC_1706 st031321 9.9705 µM -1.17458830289355 0.0925837400240033 no 3077 0.120079732629481 965 6103185 SGTC_1920 st075728 45.7 µM -1.17483241947877 0.0925368456824286 no 3078 0.120030883567764 950 3400306 SGTC_2132 5317594 122.667 µM -1.17507418115733 0.0924904210348854 no 3079 0.119982519541405 975 794577 SGTC_1395 3486-0190 4.35 µM -1.17518602639111 0.0924689496176534 no 3080 0.119960149734109 979 6748079 SGTC_3041 9091929 49.47 µM -1.17561858327192 0.0923859444994711 no 3081 0.11987366308861 961 25236887 SGTC_3220 9131269 49.47 µM -1.17926523019671 0.0916883651533295 no 3082 0.119146289419961 973 17722206 SGTC_1468 k284-1086 134 µM -1.17955706686668 0.0916327078444898 no 3083 0.119088213539697 968 15996457 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.18082270323446 0.0913916230817532 no 3084 0.118836581529611 980 6710655 SGTC_244 nsc-207895 1.295 µM -1.18327819793123 0.0909252297118363 no 3085 0.118349455216898 938 42640 SGTC_87 0100-0052 35.5 µM -1.18422161489601 0.0907465086725255 no 3086 0.118162674010144 1005 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1933 st074711 15.9 µM -1.1866026930347 0.0902965964134262 no 3087 0.117692186581901 960 17250958 SGTC_831 k061-1017 217 µM -1.18671579194803 0.0902752673031195 no 3088 0.117669871915173 1004 1240153 SGTC_970 1315-0089 19.5 µM -1.18803323816439 0.090027088218962 no 3089 0.117410157445492 960 6811083 YLR033W RSC58 SGTC_78 0336-0123 156.75 µM -1.18992752063782 0.0896711343640494 no 3090 0.117037440317788 954 6765896 SGTC_840 0245-0196 390 µM -1.19053807028926 0.0895566295021056 no 3091 0.116917488032759 983 3827528 SGTC_3056 9094900 49.47 µM -1.19150361426411 0.0893757696189561 no 3092 0.116727969312611 975 25236784 SGTC_2409 alverine citrate 63.97 µM -1.19151209647767 0.0893741819865918 no 3093 0.11672630537403 951 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_668 1682-0499 62.6 µM -1.19475113570284 0.0887694571562666 no 3094 0.116092138483124 987 682214 SGTC_3204 9114183 49.47 µM -1.19763388525104 0.0882338184752276 no 3095 0.11552978918887 954 17027248 SGTC_2582 agaric acid 100 µM -1.19821159120239 0.0881267663026133 no 3096 0.115417327003623 958 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2895 9054447 58.44 µM -1.19968558020574 0.0878540665616055 no 3097 0.115130737679924 1000 2697450 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.20033639469637 0.0877338611733012 no 3098 0.115004360246778 976 97141 SGTC_1728 st035614 33.7865 µM -1.20364480568791 0.0871246945607651 no 3099 0.11436344690324 963 15945546 SGTC_2949 9072542 2.23 µM -1.20397110522162 0.0870647856760393 no 3100 0.114300373420049 988 16457352 SGTC_304 1310-0298 97 µM -1.20419114535126 0.0870244034854759 no 3101 0.114257853795359 984 1550234 SGTC_1527 coumarin 137 µM -1.20766137064431 0.0863893898872805 no 3102 0.113588771261412 993 323 A hepatotoxic, DNA x-linker. SGTC_3310 9130229 44.1445 µM -1.21376396320792 0.0852810957856719 no 3103 0.112418935574958 984 7761258 SGTC_1459 k035-0031 35.7 µM -1.21566643303264 0.0849377748817836 no 3104 0.112056008012829 945 3877128 YMR208W ERG12 SGTC_389 tpck 16.7 µM -1.21767702305965 0.0845760697328324 no 3105 0.111673365944593 991 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_946 3434-1334 87.4 µM -1.21858029774548 0.0844139472557673 no 3106 0.111501765381881 961 4047976 SGTC_569 4130-2812 160 µM -1.22099239406141 0.0839821597403836 no 3107 0.111044449797468 975 743552 SGTC_2475 5812728 15.03 µM -1.22186398274063 0.0838265458949434 no 3108 0.110879533890846 965 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3135 9127742 49.47 µM -1.22534565214963 0.0832070870605765 no 3109 0.110222507283269 969 3643468 SGTC_1073 triclabendazole 3.09 µM -1.22651243599421 0.0830002646832352 no 3110 0.110002949186173 975 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.22868086267955 0.08261692002672 no 3111 0.109595742065022 960 6708514 SGTC_1932 st074806 40.9 µM -1.23076700844698 0.0822493805562064 no 3112 0.109205009013997 970 17251235 SGTC_423 5-fluorouracil 457 µM -1.23285252090149 0.0818831849085097 no 3113 0.10881539606886 954 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_526 4469-0568 170 µM -1.23402845093577 0.0816772455181485 no 3114 0.10859615137871 971 2901964 SGTC_1680 diphenhydramine 100 µM -1.23679516804597 0.0811942536906879 no 3115 0.1080815682044 961 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_191 3914-0123 66.505 µM -1.23881853124498 0.0808423973264125 no 3116 0.107706354772811 1003 3144412 SGTC_999 SEC7.066 22.7 µM -1.24087045326112 0.0804867515907152 no 3117 0.107326804681785 992 740511 YDR170C SEC7 SGTC_1184 1269-1718 139 µM -1.24523498821749 0.0797342089873619 no 3118 0.106522692499511 970 5403821 SGTC_2300 7976697 71.57 µM -1.24528503290321 0.0797256111445356 no 3119 0.106513497667939 962 2236109 SGTC_43 0570-0105 72.5 µM -1.24542074983879 0.0797022980552181 no 3120 0.106488564949963 977 1114046 YDL195W SEC31 SGTC_69 0096-0274 206.684 µM -1.24698260166054 0.0794343784129146 no 3121 0.106201938535475 990 6741392 SGTC_2927 9011802 47.9 µM -1.24965195109211 0.0789780577243806 no 3122 0.10571335831087 982 43912568 SGTC_3203 9113543 49.47 µM -1.24975980859948 0.0789596614913097 no 3123 0.105693650992574 981 17018012 SGTC_1144 3486-0183 12.5 µM -1.25442730121168 0.0781666771765922 no 3124 0.104843367223598 987 6744069 SGTC_3037 9091026 49.47 µM -1.25520166902854 0.0780357021239409 no 3125 0.104702779907671 979 25236398 YIL048W NEO1 SGTC_236 1509-0011 5.31 µM -1.25538999486834 0.0780038742456044 no 3126 0.104668609796903 994 3107280 SGTC_3006 9075424 71.4286 µM -1.25629638806512 0.077850827652957 no 3127 0.104504265494886 981 7465181 SGTC_3036 9090181 49.47 µM -1.25664926483266 0.0777913052636849 no 3128 0.104440333599414 998 25236586 SGTC_2756 carbadox 75.1 µM -1.25935762625883 0.0773356148759167 no 3129 0.103950593715223 954 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_695 3505-6186 243 µM -1.26044994861499 0.0771524030565408 no 3130 0.103753546370209 980 1819379 SGTC_3356 9151811 4.48 µM -1.26238625445729 0.0768284432732629 no 3131 0.103404916443575 998 1859254 YPR165W RHO1 SGTC_880 0833-0487 87.2 µM -1.26248929556808 0.0768112326799409 no 3132 0.10338638785363 982 76075 SGTC_1040 k898-0338 155 µM -1.26258656906432 0.076794988120828 no 3133 0.103368898593045 983 20969351 SGTC_321 4534-3890 65.3 µM -1.26296670955546 0.0767315301566424 no 3134 0.10330057193846 982 699746 SGTC_2868 9035608 32.47 µM -1.26390754959594 0.07657464444986 no 3135 0.103131605866884 988 6462614 SGTC_2591 skatole 100 µM -1.26397781487795 0.0765629374653571 no 3136 0.103118994938918 990 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1884 5633444 25 µM -1.26442283213425 0.0764888242089712 no 3137 0.103039151052981 973 5724239 SGTC_2992 9074591 71.4286 µM -1.26701662407476 0.0760579392804397 no 3138 0.102574672876565 990 17741321 SGTC_2755 lomerizine 42.69 µM -1.26909063211637 0.0757147332270909 no 3139 0.102204370524375 967 3949 A calcium channel blocker. SGTC_1316 1272-0050 65.9 µM -1.27106512651319 0.0753890920391955 no 3140 0.101852740238439 986 7340392 SGTC_2271 7849410 118.62 µM -1.27237818220423 0.0751731295572871 no 3141 0.101619391091524 999 972430 SGTC_2516 gossypol 71.55 µM -1.27428345397972 0.074860602635066 no 3142 0.101281489124064 999 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3290 9121031 71.43 µM -1.27465141464232 0.0748003594104448 no 3143 0.101216325337938 972 17014854 SGTC_815 1582-0027 36.9 µM -1.27512805955751 0.0747223771908688 no 3144 0.101131959601491 988 3128206 SGTC_975 1335-0046 28.5 µM -1.28095337242224 0.073774323659075 no 3145 0.100105022139533 990 16486740 SGTC_2006 4011487 200 µM -1.28213064021205 0.073583848236676 no 3146 0.0998984110674262 987 45595294 SGTC_2153 5569715 200 µM -1.28304524670786 0.0734361296699297 no 3147 0.0997381122813968 1003 2054701 SGTC_1026 k007-1105 30.6 µM -1.28328204820321 0.0733979207241353 no 3148 0.0996966398371323 979 7066794 SGTC_3280 9140961 49.47 µM -1.28504315309078 0.0731142357119186 no 3149 0.0993886023687045 1011 4901226 SGTC_838 0109-0203 71.4 µM -1.28569101715007 0.0730100868363088 no 3150 0.0992754587361941 979 759422 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.28587611093948 0.0729803525226296 no 3151 0.0992431510731724 976 1377 SGTC_933 2914-0560 114 µM -1.28648364680342 0.0728828203182947 no 3152 0.0991371612220689 981 463887 SGTC_1277 0873-0036 22 µM -1.28772571575921 0.0726837324132611 no 3153 0.0989207292979752 988 5965735 SGTC_1546 5-methoxyflavanone 78.7 µM -1.29225001773688 0.0719620643317258 no 3154 0.0981352875701325 991 147795 SGTC_1189 1431-2119 7.28 µM -1.29276006998615 0.0718810520948917 no 3155 0.0980470273057016 992 3107275 SGTC_1243 0416-0003 5.65 µM -1.29985964425377 0.0707606673006715 no 3156 0.0968245393466267 986 2141977 SGTC_1425 4048-4433 7.33 µM -1.30115527895943 0.0705576586467796 no 3157 0.0966026546947802 1025 23734946 SGTC_1239 0337-0584 35.4 µM -1.30134622304296 0.0705277781467981 no 3158 0.0965699860632149 997 914301 YML130C ERO1 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.302114051106 0.070407720292699 no 3159 0.0964387002612957 966 2346 DNA damaging agent; causes G2/M arrest. SGTC_260 nsc-65238 3.989 µM -1.30493322199188 0.0699682610519806 no 3160 0.0959577937579784 1000 3246252 SGTC_667 1498-1044 59 µM -1.30537986603867 0.0698988311830231 no 3161 0.0958817653825187 1006 6739982 SGTC_1682 st012968 530 nM -1.30796722212122 0.0694976748498414 no 3162 0.0954422135679757 974 24207270 SGTC_2722 naftopidil 47.16 µM -1.31019949223577 0.069152999471387 no 3163 0.0950641787387453 1000 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_902 1120-0002 2.07 µM -1.31079327666116 0.0690615378829747 no 3164 0.094963807326935 934 3280475 SGTC_2694 st077685 81.9 µM -1.31115260452248 0.0690062353176689 no 3165 0.0949031056284294 988 2838096 SGTC_1880 MG-132 525 µM -1.31707653402291 0.0680994215749537 no 3166 0.093906485927569 975 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1329 1447-1697 50.6 µM -1.31877114780873 0.0678417157311269 no 3167 0.0936228163593415 1011 2840515 SGTC_1703 st026983 48.3 µM -1.31920016075455 0.067776593858666 no 3168 0.0935511022874117 983 1104023 SGTC_806 3966-4455 5.86 µM -1.32152357899678 0.0674247498967886 no 3169 0.0931634229062292 988 714982 SGTC_2974 9094440 9.66 µM -1.32188893346932 0.067369551572392 no 3170 0.0931025690130689 971 25236134 SGTC_1227 3909-8010 46.6 µM -1.3230479140187 0.0671946821109178 no 3171 0.0929097221913817 997 15982272 SGTC_2818 7996756 12.99 µM -1.32994639126104 0.0661610774712639 no 3172 0.0917679674535229 1017 2241621 SGTC_275 trichlorophene 5.69 µM -1.34249132298951 0.0643130730956509 no 3173 0.0897183709669337 973 62616 SGTC_1659 st012954 42.1 µM -1.3513744254845 0.0630289374418147 no 3174 0.0882877609535806 1004 24207262 SGTC_2897 9048598 12.99 µM -1.35686415900646 0.0622453857716766 no 3175 0.087412188435027 1015 6467404 SGTC_1356 1502-0781 85.8 µM -1.35870812091733 0.0619839078364725 no 3176 0.0871195488596701 993 567702 SGTC_2440 5628896 157.78 µM -1.36320507507701 0.0613498237793587 no 3177 0.0864089441244649 1012 5522048 SGTC_1788 fluconazole 20 µM -1.36733291884383 0.0607722566373433 no 3178 0.0857604889870208 1007 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1228 0124-0032 52.5 µM -1.36893522864562 0.0605492107651573 no 3179 0.0855097612514626 997 X1228 SGTC_1472 k841-0093 193 µM -1.3691089197607 0.0605250710156175 no 3180 0.0854826152633214 1017 X1472 SGTC_2696 st077691 74.316 µM -1.37151710466858 0.0601911546556521 no 3181 0.0851069075827848 1009 757133 SGTC_3325 9138760 55.175 µM -1.37223724289177 0.0600915816700557 no 3182 0.084994797511712 979 43844959 SGTC_1766 st045414 44.774 µM -1.37290283909215 0.0599996649050287 no 3183 0.0848912769346305 984 253960 SGTC_2872 9044037 25.97 µM -1.37412320759085 0.0598314218540365 no 3184 0.084701717872513 1018 6465195 SGTC_885 0865-0106 16.8 µM -1.37646089277653 0.059510174919041 no 3185 0.0843394934251735 1004 2793380 SGTC_821 1114-0266 29.2 µM -1.37810931728796 0.0592844607592956 no 3186 0.0840847696541181 993 3123235 SGTC_2202 7226349 200 µM -1.37919834350844 0.0591357120501553 no 3187 0.0839168043358039 1009 844334 SGTC_794 k038-0031 316 µM -1.38571439932995 0.0582517993593706 no 3188 0.0829170647749917 981 6624242 SGTC_528 3492-0019 172 µM -1.38646200571925 0.058151052668871 no 3189 0.0828029370908877 985 2869262 SGTC_616 4092-0450 108 µM -1.38975526868502 0.0577088847556389 no 3190 0.0823016027495561 1016 787165 SGTC_165 k038-0023 64.381 µM -1.39086600020849 0.0575603507212811 no 3191 0.0821330322947154 1014 46368543 SGTC_1477 0139-0234 16 µM -1.3908937819304 0.0575566394321908 no 3192 0.0821288193310848 1019 620880 SGTC_3148 9097893 49.47 µM -1.39132604041811 0.0574989193704225 no 3193 0.0820632903933808 978 17174100 SGTC_2867 9039098 71.43 µM -1.39686800159646 0.0567629213021955 no 3194 0.0812266342693341 991 6463460 SGTC_2294 7971431 200 µM -1.3968692519819 0.0567627560865277 no 3195 0.0812264462306676 1028 5741572 SGTC_2956 9076196 2.52 µM -1.39843716248004 0.0565558831152029 no 3196 0.0809909150186845 1028 16423868 SGTC_3351 9150312 21.596 µM -1.40192790218287 0.0560974423616622 no 3197 0.080468388709794 1011 4904905 SGTC_2408 sulbentine 18.36 µM -1.40274601151622 0.0559904246600773 no 3198 0.0803462957145466 975 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_122 0236-0016 402.397 µM -1.40307665261316 0.055947218886077 no 3199 0.0802969912391269 998 6808838 SGTC_782 0083-0095 30.5 µM -1.41576725337153 0.0543086919504088 no 3200 0.0784218301174523 1018 3591729 An indicator and reagent. SGTC_495 decylubiquinone 155 µM -1.41638094655344 0.0542304286695304 no 3201 0.0783319996989722 1010 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2332 7982454 138.89 µM -1.41639496122497 0.0542286424443798 no 3202 0.0783299491884526 1020 2981748 SGTC_1046 2001-0062 216 µM -1.42255347131385 0.0534482106570793 no 3203 0.077432820153035 1010 739778 SGTC_1881 5652484 16 µM -1.42339116247755 0.053342746075838 no 3204 0.0773113964772856 1015 2255129 SGTC_2393 9031399 185.94 µM -1.4265220423985 0.0529500305599827 no 3205 0.076858854467924 1022 1526623 YDL150W RPC53 SGTC_385 1494-0393 12.4 µM -1.4288979802965 0.0526535427971658 no 3206 0.0765167790217044 1022 3090647 SGTC_272 doxorubicin 8.13 µM -1.43040578282332 0.0524660719580992 no 3207 0.0763002947484245 1021 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_419 nsc-638432 893 µM -1.43199888270628 0.0522685718507169 no 3208 0.0760720705372455 1007 368090 SGTC_557 1315-0110 16.2 µM -1.44072176151491 0.0511976226159084 no 3209 0.0748316522243271 1008 6833801 SGTC_303 1348-1668 34.2 µM -1.44584373151153 0.0505769558143417 no 3210 0.0741105185535215 1029 5380509 SGTC_3145 9085516 49.47 µM -1.44640696022288 0.0505090725966575 no 3211 0.0740315453968501 1032 25236195 SGTC_1539 benzyladenosine 56 µM -1.4518223094428 0.0498600848078651 no 3212 0.0732755095081 1001 92208 A nucleotide analog. SGTC_2383 9036125 200 µM -1.45822289303269 0.0491016197493986 no 3213 0.0723895578034518 1023 79580 SGTC_2833 9001315 45.46 µM -1.46059066686551 0.0488233862333718 no 3214 0.0720639045623363 1014 2989378 SGTC_1109 tnp00067 928.257 nM -1.46340152445836 0.0484947238687433 no 3215 0.0716787708963816 1022 676295 SGTC_2058 5236698 133 µM -1.46483301200026 0.0483280269595242 no 3216 0.0714832413894669 1019 766665 SGTC_2165 5727197 32.143 µM -1.46521494139521 0.0482836287770336 no 3217 0.0714311421886539 1016 1361712 SGTC_1999 st074831 12.5 µM -1.46827198641246 0.0479294309037282 no 3218 0.0710151785836726 1010 17112523 SGTC_2802 7925815 54.55 µM -1.46875363402609 0.0478738159932474 no 3219 0.0709498121228335 1016 1262923 SGTC_828 2074-0507 139 µM -1.47446740773935 0.0472179918080146 no 3220 0.070177893394991 1007 X828 SGTC_660 4031-1742 102 µM -1.47545291594148 0.0471056072186384 no 3221 0.0700454089523862 990 6738706 SGTC_1372 2752-0194 270 µM -1.47774175100923 0.046845422231485 no 3222 0.0697384573325976 1013 823334 SGTC_2432 5630864 12.22 µM -1.47882232429509 0.046722988483685 no 3223 0.0695939038396335 1016 5714970 SGTC_901 1112-0062 60.1 µM -1.48277137490818 0.0462777255502267 no 3224 0.0690675819069544 1008 1908457 SGTC_898 1000-0849 28.3 µM -1.48281842797403 0.0462724408405581 no 3225 0.0690613293084843 1025 6751807 SGTC_47 0149-0135 24.25 µM -1.48364120495886 0.0461801099098254 no 3226 0.0689520659236588 1024 5239155 SGTC_248 streptozotocin 5.23457 mM -1.4845345721863 0.0460800250434093 no 3227 0.0688335792137566 1017 5300 DNA alkylating agent. SGTC_950 1165-0508 94.1 µM -1.49658217477241 0.0447472649358326 no 3228 0.0672510055739014 1020 6148369 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.50463095929522 0.0438742963955953 no 3229 0.0662094910775313 1033 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2023 5144124 124 µM -1.51186404478621 0.0431015662334549 no 3230 0.0652842262760768 1008 2830192 SGTC_2592 piperlongumine 83.33 µM -1.5146255755974 0.0428094598688319 no 3231 0.0649336257771438 1027 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2065 5221596 34.26 µM -1.52461807304643 0.0417658283822786 no 3232 0.0636771934408421 1007 788581 SGTC_993 3909-8757 62.7 µM -1.52596501734035 0.0416267408402037 no 3233 0.0635092884585113 1028 4288324 YLR208W SEC13 SGTC_1195 1502-0147 41.1 µM -1.52669634774312 0.0415513798492073 no 3234 0.0634182680122736 1013 817940 SGTC_2110 5483698 200 µM -1.53646017891095 0.0405558019731403 no 3235 0.0622127785406413 1016 2848765 YHR062C RPP1 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.54393274051104 0.0398070093132473 no 3236 0.0613023137483824 1030 5282362 SGTC_2706 st078239 82.5 µM -1.54565089042665 0.0396364399052331 no 3237 0.0610944518059151 1038 15434492 SGTC_2339 9000433 200 µM -1.54597711292801 0.0396041213862356 no 3238 0.061055047674182 1011 2988954 SGTC_2168 5727979 200 µM -1.54847240827963 0.0393576234093998 no 3239 0.0607542998930338 1032 695210 SGTC_2137 5261020 140 µM -1.55940682090364 0.0382921465749326 no 3240 0.059450061466694 1026 763655 SGTC_2388 9080168 200 µM -1.57846857115414 0.0364910263393818 no 3241 0.0572290014450894 1030 15943073 SGTC_1072 oxiconazole 14.9 nM -1.57977187224888 0.0363704545430322 no 3242 0.0570795596683494 1010 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1378 2093-0007 380 nM -1.57990822751646 0.0363578588235402 no 3243 0.0570639423895344 1034 3618014 SGTC_82 0054-0107 293.755 µM -1.58270837536889 0.0360999857151123 no 3244 0.0567439742316841 1036 3104697 SGTC_2507 purpurin 79.67 µM -1.58721473232755 0.0356881294953203 no 3245 0.0562320096127413 1026 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_983 1491-0821 12.2 µM -1.58815192595249 0.0356029607235436 no 3246 0.0561259944371294 1026 46495113 SGTC_1311 1190-0148 100 µM -1.59362864522697 0.0351085820271671 no 3247 0.055509617333259 1029 1961333 SGTC_71 0417-1750 47.813 µM -1.61307987441022 0.0333980704731587 no 3248 0.0533635778295058 995 6811472 SGTC_2124 5246320 200 µM -1.62102814296035 0.0327191465851337 no 3249 0.05250580158726 1027 579342 SGTC_2291 7917025 104.35 µM -1.62537411699938 0.0323527611496659 no 3250 0.052041433752073 1029 2964612 SGTC_420 mitomycin C 81.9 mM -1.62846230815504 0.0320944754480115 no 3251 0.0517134475639968 1021 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3020 9089140 49.47 µM -1.63290301225559 0.0317260564102148 no 3252 0.0512446982635315 1053 17217859 SGTC_1731 st035964 63 µM -1.63310539423548 0.0317093495715666 no 3253 0.0512234161494178 1039 6739575 SGTC_2957 9076800 11.52 µM -1.63647244668588 0.0314324608706519 no 3254 0.0508703738611831 1043 16459615 SGTC_661 1304-0007 33.6 µM -1.63691341776151 0.0313963462124373 no 3255 0.0508242809628785 1050 3117130 SGTC_323 4013-0906 34.3 µM -1.64124740480702 0.0310432235775161 no 3256 0.0503730344948589 1023 2910086 SGTC_325 2810-4341 181 µM -1.64169172729387 0.0310072077286454 no 3257 0.0503269534849245 1023 774970 SGTC_1193 1488-0126 41.5 µM -1.64408658101917 0.0308136808568759 no 3258 0.0500791596921973 1033 1384710 SGTC_1782 st039423 80.636 µM -1.64903829306695 0.0304167059462013 no 3259 0.0495698949775363 1051 2068169 SGTC_707 0865-0008 204 µM -1.65618746720533 0.0298510453598952 no 3260 0.0488419302385872 1053 723043 SGTC_1278 0874-0585 172 µM -1.65941836560055 0.0295982864616159 no 3261 0.0485157590079336 1052 766306 SGTC_2062 5245942 200 µM -1.65989182002526 0.0295613969344248 no 3262 0.0484681086745925 1049 1376160 SGTC_3234 9132280 49.47 µM -1.66478432928414 0.0291824237309254 no 3263 0.0479778957287692 1032 17612295 SGTC_3152 9099253 49.47 µM -1.67203281897078 0.0286283824563036 no 3264 0.0472589253253456 1004 25236131 SGTC_1104 tacrolimus 29.8 µM -1.67755518184353 0.0282121740578285 no 3265 0.0467169841880665 1021 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_92 0063-0024 660.874 µM -1.68099817155038 0.0279552417048052 no 3266 0.0463816348592778 1060 3594437 SGTC_351 caspofungin 25 nM -1.68155916681292 0.027913562771549 no 3267 0.0463271771202687 1037 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3092 9117248 49.47 µM -1.70597126155831 0.0261493820916558 no 3268 0.0440067152087105 1066 17141857 SGTC_231 b-estradiol 524 µM -1.71070627254486 0.025818226401662 no 3269 0.0435676745992154 1048 450 A steroid. SGTC_1465 k213-0056 144 µM -1.71554495367442 0.0254834531518344 no 3270 0.0431226804475329 1010 24048857 YMR208W ERG12 SGTC_1431 4049-0260 9.09 µM -1.71878615940876 0.0252612434973864 no 3271 0.0428266583145041 1049 3854841 SGTC_1547 harmine 94.2 µM -1.72090022427211 0.025117184632009 no 3272 0.0426344654485847 1023 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3074 9116018 49.47 µM -1.72382985372867 0.024918689495882 no 3273 0.0423692817640789 1063 17027303 SGTC_926 2268-1401 59.4 µM -1.7279253181954 0.0246434100422622 no 3274 0.0420008072523924 1051 2931578 SGTC_1848 st056003 16.4 µM -1.7284735679418 0.0246067534440111 no 3275 0.0419516779444958 1028 146492 SGTC_95 0471-0001 561.058 µM -1.7296995407031 0.0245249490464847 no 3276 0.0418419854074992 1044 4015405 SGTC_9 0092-0002 10.449 µM -1.73061962714299 0.0244637052897986 no 3277 0.0417598143561864 1050 759368 SGTC_1137 ixabepilone 100 µM -1.73738892984456 0.0240170551412009 no 3278 0.0411592719592668 1039 154225 A novel microtubule stabilizer. SGTC_3211 9128781 49.47 µM -1.73851692435865 0.0239432982611008 no 3279 0.041059885293828 1026 17194361 SGTC_1268 0828-0275 2.46 µM -1.74068404174329 0.0238021297258052 no 3280 0.0408694885325278 1057 745337 SGTC_2428 5615643 7.78 µM -1.74253977178228 0.0236818020726183 no 3281 0.0407070192113351 1033 2253075 SGTC_331 k048-0133 24.5 µM -1.7486519188534 0.0232890945515225 no 3282 0.0401756029578857 1051 6813582 SGTC_2979 9012552 45.46 µM -1.75619810215695 0.0228118243702271 no 3283 0.0395272943280234 1056 17100905 SGTC_1743 st037606 46.3785 µM -1.75749588183103 0.0227305805237417 no 3284 0.0394166615869348 1037 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_444 curcumin 90.4 µM -1.76368897346408 0.0223462302725714 no 3285 0.0388921792919896 1026 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_311 1315-0136 58 µM -1.76804803194234 0.0220790017365171 no 3286 0.0385264370870461 1053 6759207 SGTC_2821 7996764 71.43 µM -1.77117216904922 0.0218891427302755 no 3287 0.0382660379027081 1018 2987135 SGTC_1648 st011736 69.8 µM -1.78096548466078 0.0213028983118164 no 3288 0.0374590447455584 1060 2855514 SGTC_281 1672-3440 14.9 µM -1.78870455625194 0.0208490669353998 no 3289 0.0368312044008731 1052 6833000 SGTC_390 dec-rvkr-cmk 16.7 µM -1.79105308991678 0.0207129745528645 no 3290 0.0366423879634486 1048 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1684 st024538 14.6195 µM -1.79380869059961 0.0205542534451507 no 3291 0.0364218546752803 1050 6732859 SGTC_3242 9133940 49.47 µM -1.7941800360117 0.0205329431399978 no 3292 0.0363922187815975 1051 17248444 SGTC_94 0334-0113 514.748 µM -1.79695656945012 0.0203741993722057 no 3293 0.0361712574137118 1048 6795178 SGTC_3258 9138477 49.47 µM -1.798100142946 0.020309120517016 no 3294 0.0360805698006973 1073 4970355 SGTC_850 0388-0143 75.9 µM -1.80638067572606 0.0198431267260449 no 3295 0.0354294489694691 1063 67273 SGTC_1852 st056254 31.4 µM -1.808333943855 0.0197345373615978 no 3296 0.0352772709803649 1060 442583 SGTC_1873 rapamycin 2 nM -1.8105465173139 0.0196121420173975 no 3297 0.0351055387377749 1030 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_320 4092-0846 5.34 µM -1.8154978979778 0.0193405746837167 no 3298 0.0347237143523084 1047 1359356 SGTC_523 1934-0222 13.7 µM -1.82084028750339 0.0190511521621603 no 3299 0.0343155691118906 1060 1361595 SGTC_878 0828-0289 13.7 µM -1.82320453073303 0.0189242502897383 no 3300 0.0341362095638167 1035 745350 YLR208W SEC13 SGTC_17 0960-0276 49.807 µM -1.82503307655398 0.0188265959972635 no 3301 0.0339980190341462 1065 6821114 SGTC_1198 1612-1005 86.7 µM -1.82581553635014 0.0187849395636924 no 3302 0.0339390261328659 1050 6998509 SGTC_1156 4092-0367 4.88 µM -1.83669806779198 0.0182136606959949 no 3303 0.0331272403385539 1052 1357585 SGTC_1100 amiodarone 5.07 µM -1.83754806983208 0.0181696699006499 no 3304 0.0330645134811978 1048 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_61 0978-8327 98.565 µM -1.84677383622934 0.0176979987835584 no 3305 0.0323899626658047 1036 6150059 YHR072W ERG7 SGTC_308 4092-1169 104 µM -1.855477462555 0.0172626399907682 no 3306 0.0317640373387382 1052 2268590 YDL196W YDL196W SGTC_1030 k029-0042 36.7 µM -1.85996593927602 0.0170417227352014 no 3307 0.0314451725260934 1046 6080581 SGTC_429 1112-0049 25.5 µM -1.87036234628564 0.0165392881883412 no 3308 0.0307167585492335 1054 2836170 SGTC_879 0831-1030 162 µM -1.87909674228191 0.016127027780765 no 3309 0.0301156424452354 1053 1549252 SGTC_2394 5221648 200 µM -1.89217557423406 0.0155261884819362 no 3310 0.0292337958246044 1069 788586 SGTC_170 4197-0004 226 µM -1.92237925479083 0.0142116260182047 no 3311 0.0272790269909568 1058 218692 SGTC_100 0086-0128 49.5915 µM -1.93497351348107 0.0136924845906414 no 3312 0.0264967730082948 1054 93297 SGTC_630 4356-0227 183 µM -1.95505591250957 0.0128985236320917 no 3313 0.0252882355972514 1066 779312 SGTC_2796 7949634 45.45 µM -1.98160065438784 0.0119103797473749 no 3314 0.02376197694383 1045 2971588 SGTC_2203 7227154 166.4 µM -1.99084307265448 0.0115820850309407 no 3315 0.0232490711702736 1070 896304 SGTC_560 2332-1943 155 µM -2.00471486051409 0.0111041054840742 no 3316 0.0224967694591643 1065 21177716 SGTC_3078 9116413 49.47 µM -2.01158909655665 0.0108736635286765 no 3317 0.0221316348605887 1051 17177322 SGTC_1280 0880-0253 10.1 µM -2.01210039267511 0.0108566910866714 no 3318 0.0221046776511739 1060 6836607 SGTC_1121 fusaric acid 630.51 nM -2.01522624726015 0.0107534290837409 no 3319 0.021940474281365 1063 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_952 1185-0122 232 µM -2.01962365303854 0.0106096097464091 no 3320 0.0217112198878226 1051 678600 SGTC_1223 0764-0573 147 µM -2.02919725851221 0.010302283182734 no 3321 0.0212191013525205 1058 1609797 SGTC_2781 5567276 71.43 µM -2.03552765027 0.0101033578311087 no 3322 0.020898904643319 1050 2853274 SGTC_982 1491-0518 27.5 µM -2.04852011902846 0.00970555730373486 no 3323 0.0202545313982606 1070 3091256 SGTC_171 k064-0041 9.68 µM -2.07076293097464 0.0090562439626644 no 3324 0.0191904779850044 1048 53325 SGTC_1888 azatryptophan 97.5 µM -2.07163284242483 0.00903164146507819 no 3325 0.0191498473372482 1074 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2159 5658611 73.75 µM -2.07468846894559 0.00894568674287717 no 3326 0.0190077083832075 1064 793844 SGTC_1740 st038286 13.222 µM -2.08184729896709 0.00874711005758386 no 3327 0.0186782099174965 1056 716786 SGTC_2419 paclitaxel 166.5 µM -2.08936673798472 0.00854270238736237 no 3328 0.018337361499591 1055 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_944 3370-0224 231 µM -2.11738278650271 0.00781755071884668 no 3329 0.0171136869518688 1065 4580514 SGTC_2197 6588183 93.1375 µM -2.16585763281491 0.00669009665956596 no 3330 0.0151610338399069 1074 884136 SGTC_3070 9117005 49.47 µM -2.17437283251905 0.00650762152915185 no 3331 0.0148385733367034 1088 8779016 SGTC_1274 0865-0114 173 µM -2.18272800664416 0.00633286873413852 no 3332 0.0145279230873203 1080 870624 SGTC_64 000l-0018 272.079 µM -2.21970306915875 0.00560840041877351 no 3333 0.0132194651888626 1054 6811119 SGTC_951 1171-0579 82.7 µM -2.22076699660694 0.0055886908507647 no 3334 0.0131833735101827 1053 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3156 9099931 49.47 µM -2.2299307515878 0.00542146045220429 no 3335 0.0128760202423895 1083 18111053 SGTC_36 0335-0881 14.2 µM -2.27966567325359 0.00458911341153938 no 3336 0.0113137623388662 1054 23828853 SGTC_2417 cerulenin 830 nM -2.34391046669153 0.0036835651834187 no 3337 0.00954137583010547 1077 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2016 5121758 140 µM -2.37121536983829 0.00334986785710369 no 3338 0.00886484828445486 1069 2795203 SGTC_750 4073-0104 132 µM -2.37522229284196 0.00330325498099591 no 3339 0.00876919216705958 1027 22330957 SGTC_2936 9038235 15.59 µM -2.37557114197468 0.00329922451861021 no 3340 0.0087609071703636 1061 4749415 SGTC_1473 k844-0725 134 µM -2.45904497249898 0.00245278262576716 no 3341 0.00696535829436362 1086 54682906 SGTC_2287 7945887 168.79 µM -2.53066013817246 0.00188890091329778 no 3342 0.00569240510602682 1083 1245853 SGTC_2280 7785178 200 µM -2.56882938983451 0.00163912617505105 no 3343 0.00510213412513232 1078 2954328 SGTC_888 0916-0002 6.97 µM -2.65524347561726 0.00118099083957771 no 3344 0.00396255922234107 1084 2802138 YIL048W NEO1 SGTC_1458 k015-0034 6.33 µM -2.65615896112006 0.0011768378178934 no 3345 0.00395181743250874 1089 3598957 SGTC_162 k030-0015 37.8 µM -2.69620352474554 0.00100774573859757 no 3346 0.00350673999204294 1091 1809920 YMR134W ERG29 SGTC_626 0214-0009 33 µM -2.69909272772599 0.000996453121780405 yes 3347 0.00347644001662019 1090 3437874 SGTC_2987 9018338 71.43 µM -2.78392476012183 0.000712415722227073 yes 3348 0.00268527453923577 1084 5055682 SGTC_332 4112-0506 40.9 µM -2.80409601679636 0.000656911269372701 yes 3349 0.00252289380940648 1088 2790355 SGTC_457 grayanotoxin iii 135 µM -2.95358577852818 0.000354415215199121 yes 3350 0.00157052650373395 1069 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_312 4092-0653 6.84 µM -2.97705116729728 0.000320873939302565 yes 3351 0.00145517716829337 1069 1148278 SGTC_1036 k216-0215 33.5 µM -2.98018012057056 0.000316631516030149 yes 3352 0.00144039468511063 1034 622330 SGTC_980 1473-0395 201 µM -3.15842315930188 0.000145342234386418 yes 3353 0.000793125604715592 1094 768876 SGTC_318 1488-0629 67.2 µM -3.182435868394 0.000130466152635294 yes 3354 0.000730209272519723 1092 3662576 SGTC_984 1492-0255 2.91 µM -3.42458674754747 4.21494507385671e-05 yes 3355 0.000307867617823669 1091 1585198 SGTC_322 k048-0136 19.3 µM -3.5333467737132 2.47636789989075e-05 yes 3356 0.000205166934160245 1095 6823282