SGTCid condition conc unit LCB3|YJL134W.score LCB3|YJL134W.strain.pval LCB3|YJL134W.strain.significant LCB3|YJL134W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_457 grayanotoxin iii 135 µM 12.8004530725 2.08301114325288e-36 yes 1 8.14987305565257e-38 4 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1781 st038725 66.3 µM 5.88685026100944 3.50863499432358e-09 yes 2 1.96812518852322e-09 58 4270275 YIL048W NEO1 SGTC_1568 digitonin 820 nM 5.57724191850005 2.03289097531043e-08 yes 3 1.22180965166804e-08 14 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1318 1280-3875 124 µM 5.36258218592692 6.5225577555271e-08 yes 4 4.10203102424643e-08 5 373245 SGTC_266 formosanin C 406 nM 4.66634477899755 2.13418256643776e-06 yes 5 1.533025327901e-06 52 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_179 1273-0063 6.77 µM 4.63483952663488 2.47280462505783e-06 yes 6 1.78607240507319e-06 14 3108139 SGTC_2502 avocadyne acetate 18.59 µM 4.37452287361147 8.06335587323737e-06 yes 7 6.08491813359459e-06 20 3952079 SGTC_366 0181-0206 4.31 µM 4.34206456280637 9.30316207064267e-06 yes 8 7.05750192876357e-06 30 274874 SGTC_2081 5214970 32.255 µM 4.27470352208975 1.24796547466507e-05 yes 9 9.56959027393009e-06 19 2063512 SGTC_490 phenamil 164 µM 4.11685383120517 2.44397429557987e-05 yes 10 1.92039743910067e-05 7 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_546 peri-Naphthalide 147 µM 4.03890582463173 3.37752382244094e-05 yes 11 2.68505594922114e-05 17 223824 A penicillin ester. SGTC_1438 4092-1045 4 µM 3.68325180384305 0.00013779950628247 yes 12 0.000115138743738919 10 1351342 SGTC_528 3492-0019 172 µM 3.6789149915972 0.000140083442974325 yes 13 0.00011711415905567 242 2869262 SGTC_2956 9076196 2.52 µM 3.6702281301559 0.000144765374009552 yes 14 0.00012116704693251 27 16423868 SGTC_1995 st072814 61.1 µM 3.5932916833642 0.000193120140163636 yes 15 0.000163263357850188 19 5769371 SGTC_2165 5727197 32.143 µM 3.35180033510756 0.000460956010183247 yes 16 0.000401439502579042 59 1361712 SGTC_2079 5212404 121 µM 3.30930107844711 0.000534318590792434 yes 17 0.000467646005066435 25 758462 SGTC_2524 avocatin b 10.57 µM 3.26066010421074 0.000631464232196169 yes 18 0.000555765974952704 44 6710748 SGTC_481 bay k-8644 50 µM 3.22093578841785 0.000722631021534348 yes 19 0.000638863860407585 52 2303 A calcium channel antagonist. SGTC_6 0844-0013 19.835 µM 3.21244236619758 0.000743634492236955 yes 20 0.000658057760749818 172 1584900 SGTC_463 ikarugamyin 104 µM 3.12192704709443 0.00100514710776915 no 21 0.000898357276740564 8 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1876 myriocin 605 nM 3.10527750729154 0.00106159037762259 no 22 0.000950502895878433 64 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1459 k035-0031 35.7 µM 3.09892686982101 0.00108387470283463 no 23 0.000971114772383088 51 3877128 YMR208W ERG12 SGTC_1314 1222-0010 41.1 µM 3.09496705895576 0.0010979858563462 no 24 0.000984173783092931 37 3526027 SGTC_2799 7812892 81.82 µM 3.08756228515573 0.00112482620936185 no 25 0.00100902738173357 64 20205235 SGTC_619 1652-1634 108 µM 3.03065316794291 0.00135203998260997 no 26 0.00122012690471581 56 5400454 SGTC_1553 gossypol 38.6 µM 3.00682967693206 0.00145904431771751 no 27 0.00131993814547062 11 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2397 5161689 200 µM 2.9860772257718 0.00155849407024306 no 28 0.00141290635822379 84 2259942 SGTC_2762 leflunomide 42.06 µM 2.98035737444552 0.00158697079954705 no 29 0.00143956138081265 77 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_474 dl-dihydrosphingosine 5 µM 2.94274071254159 0.00178637102974664 no 30 0.00162660382117019 87 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2618 avocadyne 43.43 µM 2.94050976236701 0.00179888394964224 no 31 0.00163836337963272 71 3015189 SGTC_2961 9083290 32.55 µM 2.92839311588681 0.00186824660727094 no 32 0.00170359477833023 56 17741490 SGTC_2242 6630449 61.2675 µM 2.90744981437184 0.00199389320368248 no 33 0.00182194403900524 85 691249 YDR170C SEC7 SGTC_2924 9010168 62.78 µM 2.90243742650106 0.00202508038005664 no 34 0.00185135561200533 90 2993929 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.89652490480648 0.00206243701545937 no 35 0.00188660345876998 55 6708784 An antioxidant flavonoid SGTC_3023 9089636 49.47 µM 2.88496034963878 0.00213731749377082 no 36 0.00195731480903009 30 17249241 SGTC_356 1634-0012 32.5 µM 2.88462994844675 0.00213949261275088 no 37 0.00195936995653433 78 735457 SGTC_2581 avocatin a 64 µM 2.84197181082894 0.00243777637009835 no 38 0.00224177278624956 115 6710728 A skin care supplement. SGTC_825 1988-2224 89.6 µM 2.82717492811423 0.00254972171912449 no 39 0.00234803336411509 100 1180859 SGTC_2997 9067075 71.4286 µM 2.82079360252894 0.00259941760674117 no 40 0.00239525068827502 124 27209819 SGTC_2513 baicalein 25.65 µM 2.8017687585852 0.00275281435266039 no 41 0.00254116442655889 74 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1436 4092-1007 8.32 µM 2.77041511779262 0.00302351819170198 no 42 0.00279924451396473 63 2881121 SGTC_1928 4'-methoxychalcone 40.3 µM 2.76026486523964 0.00311615944193649 no 43 0.00288772581422328 54 641818 SGTC_1087 pterostilbene 9.05 µM 2.7564694632896 0.00315145126252334 no 44 0.00292145340860892 97 5281727 Similar to reservatol, lowers cholesterol. SGTC_3026 9090633 49.47 µM 2.75547061247345 0.00316079875103109 no 45 0.00293038845866136 84 25236842 SGTC_3311 9131146 2.8755 µM 2.74139653669468 0.00329518636282281 no 46 0.0030589312411801 199 4900406 YPR165W RHO1 SGTC_1804 st050076 49.1 µM 2.73762493946507 0.00333206218100664 no 47 0.00309423041783061 85 3895976 SGTC_3036 9090181 49.47 µM 2.73364561751133 0.00337137080125994 no 48 0.00313187098100047 39 25236586 SGTC_304 1310-0298 97 µM 2.7329551118161 0.00337823404952005 no 49 0.00313844430982383 147 1550234 SGTC_2343 7990716 14.84 µM 2.72842113023319 0.00342361212535729 no 50 0.00318191530591059 78 6456862 SGTC_1292 0kpi-0043 232 µM 2.7126448498287 0.00358580728019084 no 51 0.00333743009368431 78 3333905 SGTC_3172 9105863 49.47 µM 2.66983504746698 0.0040612368733679 no 52 0.0037944259091743 27 2348785 SGTC_2607 solasodine 47.35 µM 2.6527920777872 0.00426570280659128 no 53 0.00399145141719262 139 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_951 1171-0579 82.7 µM 2.63368034394671 0.00450589432560642 no 54 0.00422324830505647 194 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_50 0929-0078 56.389 µM 2.63261318658897 0.00451965533410391 no 55 0.0042365392705983 139 1377751 SGTC_741 4582-0002 126 µM 2.62622684292849 0.00460279432746012 no 56 0.00431686290437677 94 2912688 SGTC_2208 7283366 200 µM 2.62204135473211 0.00465801981778513 no 57 0.00437024121572121 72 898663 SGTC_169 k015-0017 16.025 µM 2.61939515878187 0.0046932394074539 no 58 0.00440429221860625 77 1840002 SGTC_1999 st074831 12.5 µM 2.61270308318437 0.00478336997745915 no 59 0.00449146526900835 115 17112523 SGTC_552 k242-0005 476 µM 2.61126193835075 0.00480298047431291 no 60 0.00451043849358456 88 4088318 SGTC_1556 plumbagin 1.48 µM 2.60273626747911 0.0049204674315587 no 61 0.00462415332712137 76 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2100 5377183 190 µM 2.60217254756761 0.00492832520930746 no 62 0.00463176158780398 86 2844202 SGTC_1654 st012436 41.8 µM 2.58332988058181 0.0051974924209071 no 63 0.00489258557121836 81 4323132 SGTC_3169 9102970 49.47 µM 2.57389491021106 0.00533712386656898 no 64 0.00502804061361958 56 17027839 SGTC_705 1124-0212 310 µM 2.57380316932068 0.00533849779127114 no 65 0.0050293739444878 87 9554485 SGTC_284 0988-0104 32.6 µM 2.5705979952171 0.00538669680233588 no 66 0.00507615496815304 74 4666532 SGTC_306 1672-3436 11.6 µM 2.52741247371667 0.00607487723267067 no 67 0.00574532307227357 96 6797378 SGTC_3167 9103034 49.47 µM 2.52008345903422 0.00619910384102791 no 68 0.00586635059111145 45 5127859 SGTC_103 0844-0104 51.839 µM 2.51871459169177 0.00622255387558133 no 69 0.00588920433794992 272 5375804 SGTC_450 aminopyrene 156 nM 2.51317379061964 0.00631827771826028 no 70 0.00598251879661376 136 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_171 k064-0041 9.68 µM 2.50336684089116 0.00649090345852522 no 71 0.00615089810997317 94 53325 SGTC_779 1360-0071 233 µM 2.5008158940251 0.00653648446562308 no 72 0.00619537866717179 139 7566 SGTC_53 0973-0023 39.979 µM 2.492929806603 0.00667919051156704 no 73 0.00633469448340769 106 674768 SGTC_1945 st075991 56.6 µM 2.48879443910531 0.0067551188956954 no 74 0.00640885260531499 115 1084980 SGTC_1489 4065-0444 182 µM 2.48628319994757 0.00680159838157905 no 75 0.00645425976247366 98 2877968 SGTC_41 0478-0632 82.643 µM 2.47144070897983 0.00708212491328836 no 76 0.00672849321309976 154 3750424 SGTC_2922 7999257 32.47 µM 2.4620563665295 0.00726471479204878 no 77 0.00690714772388725 83 2988377 SGTC_618 k072-0232 33.2 µM 2.44762809482995 0.00755354302313196 no 78 0.00718999999408089 92 5872756 YGL099W LSG1 SGTC_1233 0325-0408 14.2 µM 2.4455236945752 0.00759650366470128 no 79 0.00723209720011117 108 12874 SGTC_7 0192-1582 4.227 µM 2.41482860337232 0.00824803796086583 no 80 0.00787130781859718 206 252616 SGTC_406 estrone 100 µM 2.36229238641456 0.00947751766708627 no 81 0.00908115565469841 110 5870 A steroid. SGTC_1367 1812-0510 76.9 µM 2.35457824299763 0.0096709246155986 no 82 0.00927186965825361 143 1142582 YDR527W RBA50 SGTC_309 k408-0051 1.48 µM 2.34227331417171 0.00998657106087456 no 83 0.00958333663257971 224 3640463 SGTC_1573 oleylamine 1.06 µM 2.33098845469309 0.0102839185906076 no 84 0.00987698423679157 168 5356789 An amine of the fatty acid oleic acid. SGTC_2758 dehydroepiandrosterone 69.35 µM 2.32821520773752 0.0103581626880089 no 85 0.00995033952798958 163 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1126 isoteolin 1.0172 µM 2.32325435836717 0.0104921383357079 no 86 0.0100827460757185 168 133323 SGTC_3256 9138902 49.47 µM 2.32133540548949 0.0105443663263068 no 87 0.0101343743937783 54 17228773 SGTC_781 4335-2806 94.4 µM 2.28058619077042 0.0117081570836771 no 88 0.0112864726069185 154 845254 SGTC_1339 1486-1321 22.7 µM 2.2766905222843 0.0118250462961125 no 89 0.0114023564466875 152 3469382 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.26796068742529 0.0120906667945091 no 90 0.0116658014400536 379 16725076 SGTC_840 0245-0196 390 µM 2.26607195552283 0.0121488106240909 no 91 0.0117234889977797 153 3827528 SGTC_1293 1000-1278 195 µM 2.25392785091139 0.012528482298394 no 92 0.0121003536235447 165 678847 SGTC_3163 9099914 49.47 µM 2.2393714457842 0.0129970708267698 no 93 0.0125658788415061 60 16268368 SGTC_1540 guanosine 70.6 µM 2.23460855140926 0.0131536491474397 no 94 0.0127215294722229 112 6802 Guanosine is a purine nucleoside SGTC_2854 9024559 71.43 µM 2.23409517659467 0.013170623067953 no 95 0.0127384056595714 180 3163529 SGTC_1323 1348-1351 11.2 µM 2.22899760227756 0.0133401958115048 no 96 0.0129070321601098 128 6989654 SGTC_1451 4152-0210 104 µM 2.20632850300669 0.01411732137936 no 97 0.0136805035324596 185 659563 SGTC_1650 st011916 45.8 µM 2.20251778903643 0.0142517164794136 no 98 0.0138143769814244 116 242528 SGTC_1135 dihydrocapsaicin 536.708 nM 2.20118406012858 0.0142990136744637 no 99 0.0138614981337084 196 107982 A Capsaicinoid. SGTC_2425 5628681 7.85 µM 2.19905657867462 0.0143747390274189 no 100 0.013936949751303 195 5714958 SGTC_2195 6536160 144.242 µM 2.18048104142039 0.0150507103797161 no 101 0.0146109113266839 135 3834386 SGTC_2558 carylophyllene oxide 100 µM 2.1803216904092 0.0150566254358511 no 102 0.0146168121730888 164 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1809 st050081 57.6 µM 2.17600087209289 0.0152177760062404 no 103 0.014777597674018 169 5036894 SGTC_553 k007-0256 45.7 µM 2.17527929855336 0.0152448319063298 no 104 0.0148045964344836 179 6287000 SGTC_2371 9071574 200 µM 2.15946025116869 0.0158484447372606 no 105 0.0154072389465494 134 45596039 SGTC_1207 2099-0101 141 µM 2.15469215538856 0.0160343555994644 no 106 0.0155929660388329 185 5837381 SGTC_850 0388-0143 75.9 µM 2.15282231662015 0.0161077702869914 no 107 0.0156663227772561 169 67273 SGTC_1290 0986-0249 10.2 µM 2.14938013491378 0.0162436725639379 no 108 0.0158021394228703 135 53329 SGTC_1571 st070080 73.4 µM 2.14563580364764 0.016392618283226 no 109 0.0159510232994841 175 4315245 SGTC_1030 k029-0042 36.7 µM 2.12867100141029 0.0170821996019124 no 110 0.0166407448270201 222 6080581 SGTC_1910 st062352 60.4 µM 2.12279870569821 0.0173266024809871 no 111 0.0168853616791384 226 2245730 SGTC_2273 7815444 169.05 µM 2.12228172251123 0.0173482614804612 no 112 0.0169070436998658 178 2824616 SGTC_1427 4048-4900 550 nM 2.11944828180072 0.0174673795249454 no 113 0.0170263000655315 184 24132586 SGTC_1733 st037357 54.9 µM 2.11505256576162 0.0176535575523906 no 114 0.0172127336966413 224 1272339 YGL099W LSG1 SGTC_273 hydroxyurea 18.1 mM 2.11291013561395 0.0177449111026716 no 115 0.0173042300942815 239 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_345 1362-0200 395 µM 2.10891969645756 0.0179161395345399 no 116 0.0174757568795062 187 1419823 SGTC_942 3253-1115 227 µM 2.10609103467428 0.0180383681905262 no 117 0.0175982227266069 195 46497897 SGTC_1111 tnp00062 510.699 nM 2.09025694349047 0.0187357765888076 no 118 0.0182973623915635 166 676306 SGTC_1084 voriconazole 435 nM 2.0783240049227 0.0192764054375917 no 119 0.0188397634675288 187 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1555 citronellol 128 µM 2.05753935312421 0.0202497325338727 no 120 0.0198171867676876 129 8842 A terpine precursor. SGTC_964 1287-0107 19.4 µM 2.05151549347754 0.0205394954502239 no 121 0.0201083861923413 247 51516812 YPR165W RHO1 SGTC_1545 lovastatin 49.4 µM 2.02094622189919 0.022064657302385 no 122 0.0216426661927395 246 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2308 7584454 197.62 µM 2.01464076376705 0.0223908657773482 no 123 0.0219711515205343 255 893577 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.01336196620624 0.0224575172507239 no 124 0.0220382818828884 314 6708739 YPR165W RHO1 SGTC_2777 climbazole 1.536 µM 2.00784718224273 0.0227468698448001 no 125 0.022329766637237 251 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1942 st076330 65.2 µM 2.00468853061476 0.0229140102857327 no 126 0.022498177715324 229 24208414 SGTC_337 1315-0038 354 µM 2.000801608319 0.0231211060163071 no 127 0.0227068870196618 205 1626437 SGTC_2344 7990960 76.95 µM 1.99532681172165 0.0234154753955675 no 128 0.0230036237491349 215 140813 SGTC_1209 2323-2347 50.3 µM 1.99403762104749 0.0234852495922926 no 129 0.0230739716550878 185 5412760 SGTC_2227 7312221 64.1025 µM 1.98670301319735 0.0238855533929271 no 130 0.0234776588596192 116 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1886 st057356 49.9 µM 1.98359638982465 0.0240568255930826 no 131 0.0236504259974631 210 24207747 SGTC_3335 9143315 29.6265 µM 1.96857263844653 0.024899732149155 no 132 0.0245010935827016 212 4899691 SGTC_2098 5376439 882.5 nM 1.95956524038616 0.0254168667488426 no 133 0.0250233137382294 227 2844116 SGTC_2253 7938677 135.83 µM 1.95827455648876 0.025491699498229 no 134 0.0250989023466368 194 2301972 SGTC_2434 5670830 169.91 µM 1.9576175324229 0.0255298640059515 no 135 0.0251374542629659 256 1549830 SGTC_38 0929-0051 58.268 µM 1.94300087697134 0.026391350648248 no 136 0.0260080261783454 264 1379719 SGTC_724 3910-0327 137 µM 1.94163465302995 0.0264731013257183 no 137 0.0260906723496119 241 2885483 SGTC_2546 rhodinyl acetate 100 µM 1.93173572675131 0.0270717655366732 no 138 0.0266960663635803 232 6708682 SGTC_1210 3013-0140 750 nM 1.93059106656584 0.0271417150626117 no 139 0.0267668217505262 203 905973 SGTC_668 1682-0499 62.6 µM 1.93047883593293 0.0271485815226811 no 140 0.0267737675344487 268 682214 SGTC_549 1661-1316 519 µM 1.92609008854753 0.0274182312264707 no 141 0.0270465629979424 240 2857282 SGTC_1951 sophoraflavanone G 9.2 µM 1.92414820452489 0.0275382535669031 no 142 0.0271680046544735 260 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2297 7971671 152.32 µM 1.92390909408428 0.0275530625456893 no 143 0.0271829895674198 238 909016 SGTC_2222 6885208 172.143 µM 1.91907944263063 0.0278536045351563 no 144 0.0274871403436355 143 609514 SGTC_425 3825-7017 13.1 µM 1.91852809232754 0.027888087272521 no 145 0.0275220417776515 281 3397440 SGTC_1991 st073000 8.92 µM 1.90652236577059 0.0286478154569452 no 146 0.028291233367863 328 4301969 YIL048W NEO1 SGTC_292 k038-0015 474 µM 1.90621475784354 0.0286675049809021 no 147 0.028311174149005 236 46368540 SGTC_48 0382-0018 55 µM 1.90201968077961 0.028937150705732 no 148 0.0285842908524133 207 762596 SGTC_1373 2887-0003 58.5 µM 1.90026397325632 0.0290506258536706 no 149 0.0286992433388061 260 776948 SGTC_634 1611-4317 11.2 µM 1.89480458725231 0.0294058424781692 no 150 0.0290591476280929 269 2843522 SGTC_1998 st075797 76.8 µM 1.89432623715819 0.0294371375763139 no 151 0.0290908602674659 264 24208315 SGTC_2259 7964009 200 µM 1.88417947934483 0.0301075098989777 no 152 0.0297703511485923 236 313134 SGTC_1897 st060201 15 µM 1.87744880348637 0.0305591346890577 no 153 0.0302283039758269 230 611878 SGTC_710 3448-4187 58 µM 1.8725262023682 0.0308929793234675 no 154 0.0305669201684917 362 3946412 SGTC_1509 1326-1131 80 µM 1.86836947911179 0.0311772286026593 no 155 0.0308552941161448 219 768313 SGTC_444 curcumin 90.4 µM 1.8574347100217 0.0319353263002823 no 156 0.0316246660284493 273 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2751 anetholtrithion 17.25 µM 1.84449635055121 0.032851929233802 no 157 0.0325554185963366 271 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_761 k216-0224 480 µM 1.83285165589197 0.0336953234095069 no 158 0.0334123174036172 269 1340404 SGTC_760 0568-0725 82.9 µM 1.83014036144509 0.0338942314120943 no 159 0.0336144764667037 247 3916171 SGTC_632 0781-2353 4.65 µM 1.82606989110566 0.0341946648754195 no 160 0.0339198674113417 310 6811515 YHR007C ERG11 SGTC_722 3534-0461 190 µM 1.82464700121105 0.0343002005929432 no 161 0.0340271579162438 291 658262 SGTC_1152 3909-8331 15.9 µM 1.81871612855461 0.0347429805146999 no 162 0.0344773748959801 245 16001939 SGTC_101 0490-5701 117.494 µM 1.81642819934238 0.0349150397377453 no 163 0.0346523563684911 226 4661669 SGTC_3227 9130768 49.47 µM 1.81570389088944 0.0349696554751844 no 164 0.0347079034467746 208 17720899 SGTC_2452 5863136 48.41 µM 1.81136117415652 0.035298585910529 no 165 0.0350424809490868 282 2184096 SGTC_2942 9052777 62.25 µM 1.80898097016775 0.0354799436793721 no 166 0.0352269799081521 325 6469503 SGTC_823 0417-1665 178 µM 1.80391103267319 0.0358687908269814 no 167 0.0356226275733075 295 3429856 SGTC_607 4491-0986 66.8 µM 1.8030563586062 0.0359346840879326 no 168 0.0356896820251375 284 698981 YDR232W HEM1 SGTC_2923 7992654 58.14 µM 1.79996081054159 0.0361741736656852 no 169 0.0359334132360003 291 2985126 SGTC_3184 9108758 49.47 µM 1.79640417890595 0.0364509470410707 no 170 0.0362151298661188 230 902885 SGTC_1007 4101-0031 70 µM 1.79618548902627 0.0364680216584517 no 171 0.0362325108817984 290 1146276 SGTC_97 0535-0701 19.132 µM 1.7897067219452 0.0369768397044775 no 172 0.0367505356092215 252 2832013 YGL099W LSG1 SGTC_1181 1222-0449 220 µM 1.78804726117521 0.037108096977507 no 173 0.0368841915998702 280 658318 SGTC_736 0958-0254 92.6 µM 1.78716074913903 0.0371783727312062 no 174 0.0369557556032666 322 6812352 SGTC_1752 st044819 83.042 µM 1.7718489369799 0.0384094273157779 no 175 0.0382098183217798 297 441209 YML126C ERG13 SGTC_2180 6301957 200 µM 1.76136647532978 0.0392712153036053 no 176 0.0390881977087674 237 845462 SGTC_1905 st060207 84.5 µM 1.75807018976952 0.0395454402185892 no 177 0.0393677836246587 263 1948547 SGTC_1009 4106-0057 9.87 µM 1.75539995434271 0.0397687227951725 no 178 0.0395954599403396 307 2928005 SGTC_1500 4488-1866 171 µM 1.75191686502155 0.0400615147570487 no 179 0.0398940520683797 315 2900003 SGTC_322 k048-0136 19.3 µM 1.74193322728043 0.0409104654352526 no 180 0.0407600644754191 283 6823282 SGTC_2655 perillic acid 100 µM 1.72193183232517 0.042655165585551 no 181 0.0425409338751609 220 5702197 An apoptosis inducer. SGTC_699 0375-0592 111 µM 1.71503043808252 0.0432709460409496 no 182 0.0431698232529486 289 762578 SGTC_2162 5663267 200 µM 1.71468277313409 0.0433021555660568 no 183 0.0432017018266013 281 6456493 SGTC_1109 tnp00067 928.257 nM 1.71327938243149 0.0434283213263359 no 184 0.0433305767794153 282 676295 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.71182265821074 0.0435595955251143 no 185 0.0434646775650098 282 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3134 9127454 49.47 µM 1.7102660868875 0.0437002212975936 no 186 0.0436083399575445 280 24262820 SGTC_621 3584-0052 32.1 µM 1.7094577611919 0.043773392474347 no 187 0.0436830947023141 328 2273927 SGTC_2416 tofa 880 nM 1.70893812669989 0.0438204829469291 no 188 0.0437312055823192 338 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2018 5133068 143 µM 1.70564655241088 0.0441197230400366 no 189 0.0440369532057084 326 785362 SGTC_1682 st012968 530 nM 1.70378657939338 0.0442895420817093 no 190 0.0442104830705796 276 24207270 SGTC_352 k048-0007 5.11 µM 1.69019493185937 0.0455465318042935 no 191 0.0454953338356063 388 6811911 SGTC_2767 sibutramine 71.45 µM 1.68326082329523 0.0461987786101525 no 192 0.0461623054444675 327 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3008 9078912 71.4286 µM 1.67709609697374 0.0467849340386475 no 193 0.046761845955486 299 16648731 SGTC_605 1315-0399 119 µM 1.66220911593839 0.0482250326337987 no 194 0.048235426430864 377 24020461 SGTC_2677 mitomycin C 100 µM 1.66215418492405 0.0482304113453876 no 195 0.0482409317550654 270 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1071 trifluoperazine 6.31 µM 1.66151196444905 0.0482933316292753 no 196 0.0483053340054756 367 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1648 st011736 69.8 µM 1.65438493952271 0.0489960042124081 no 197 0.0490246622611009 329 2855514 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.63890280572202 0.050550571334511 no 198 0.0506167516563642 296 6857784 SGTC_487 nimodipine 119 µM 1.6360792222818 0.0508382799601382 no 199 0.0509115040604077 224 4497 L-type voltage-gated calcium channels inhibitor SGTC_275 trichlorophene 5.69 µM 1.63552373784777 0.0508950341465586 no 200 0.0509696513248297 565 62616 SGTC_3057 9095946 49.47 µM 1.63476324391719 0.0509728160655641 no 201 0.0510493443859949 313 24540043 SGTC_1992 st073643 23.3 µM 1.63149447485946 0.0513082177229013 no 202 0.0513930123709833 326 3161292 SGTC_1791 st048313 56.1 µM 1.63143242133426 0.0513146018470786 no 203 0.0513995542360163 296 1204976 SGTC_405 ebelactone b 50 µM 1.63114937535379 0.0513437298950398 no 204 0.0514294021762755 371 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1898 st060199 18.6 µM 1.62880690112211 0.0515852972629359 no 205 0.0516769516593745 318 688866 SGTC_1883 5-benzylidenerhodanine 20 µM 1.62601728581555 0.0518741539240467 no 206 0.0519729890963746 444 1273210 SGTC_2120 5538279 151.968 µM 1.62171817783975 0.0523218294503296 no 207 0.0524318524011865 351 2058197 SGTC_822 1487-0950 154 µM 1.61557002942713 0.052967373954022 no 208 0.05309365405571 346 1958375 SGTC_3005 9076496 71.4286 µM 1.61407998975503 0.0531247725475618 no 209 0.0532550385585103 307 21368410 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.61371470107708 0.0531634159346512 no 210 0.0532946618492122 397 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1709 st033179 39.1045 µM 1.61297536546719 0.0532416974296308 no 211 0.0533749299557783 387 573381 SGTC_616 4092-0450 108 µM 1.61231283323627 0.0533119245182877 no 212 0.0534469410510119 387 787165 SGTC_1801 st050089 28.441 µM 1.61134142001339 0.053415025092353 no 213 0.0535526638038727 493 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1347 1493-0251 600 nM 1.61022903413939 0.0535332817398938 no 214 0.053673932589247 370 3986378 SGTC_1208 2323-2347 50.3 µM 1.60695181559105 0.0538828856559892 no 215 0.0540324692577073 332 5412760 SGTC_1842 st055362 61.2 µM 1.5986064967285 0.0547813043385039 no 216 0.0549540326370073 393 676032 SGTC_1835 st008666 49.2 µM 1.59267981772914 0.0554265037680658 no 217 0.0556160186903419 312 690455 SGTC_451 chloral hydrate 100 µM 1.58720501674756 0.056027827377433 no 218 0.0562331094636737 461 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2520 obtusaquinone 4.71 µM 1.58308923712446 0.0564832620139558 no 219 0.0567005631987665 370 5967872 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.58102458981048 0.0567128233536465 no 220 0.0569362077176553 354 689007 SGTC_277 nystatin 15.5 µM 1.57755387626024 0.057100376023219 no 221 0.0573340678279431 399 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1819 st053448 58.6 µM 1.57725588349422 0.0571337479408042 no 222 0.0573683295105947 362 2857616 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.57621726667402 0.0572501816358512 no 223 0.0574878702879589 444 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3079 9117512 49.47 µM 1.5742656771842 0.0574694687621459 no 224 0.0577130206144726 313 7185044 SGTC_3098 9119039 49.47 µM 1.57253917629462 0.0576640145281611 no 225 0.0579127805021963 382 17161528 SGTC_594 1487-1584 10.8 µM 1.57187877901229 0.0577385662818457 no 226 0.057989333444343 386 5013332 SGTC_978 1416-0512 87.4 µM 1.56909661067216 0.058053475666411 no 227 0.058312714711586 439 6814003 SGTC_2059 5238311 157 µM 1.56479547093322 0.0585429694477654 no 228 0.0588154370282538 368 703021 SGTC_527 4476-4215 268 µM 1.56166368880175 0.0589014181819738 no 229 0.0591836185895847 390 4418754 SGTC_1163 k060-0048 49.9 µM 1.56099621966636 0.0589780356574277 no 230 0.05926232141301 429 6809982 SGTC_515 4092-1064 102 µM 1.55977587231529 0.0591183190786521 no 231 0.0594064275457132 457 717353 SGTC_1810 st050138 53 µM 1.558779536028 0.0592330455534933 no 232 0.0595242846470603 321 3444541 SGTC_703 3875-0075 71.8 µM 1.54971171849966 0.0602852310691188 no 233 0.0606053621069648 362 2850814 SGTC_2364 9055074 200 µM 1.54837390881383 0.0604416948030629 no 234 0.0607661496274269 365 6470630 SGTC_2654 protoveratrine a 100 µM 1.53770098298024 0.0617013530501302 no 235 0.0620608716017104 379 5702278 A heart drug and vasodilator. SGTC_934 2950-0684 338 µM 1.53743500812271 0.0617330041663794 no 236 0.0620934095023726 428 1121253 SGTC_2047 4141938 200 µM 1.53533348629813 0.061983532042088 no 237 0.0623509663541236 342 3807862 SGTC_3258 9138477 49.47 µM 1.53496138560787 0.0620279736931454 no 238 0.0623966567052247 372 4970355 SGTC_3109 9122853 49.47 µM 1.53415748525914 0.0621240719899621 no 239 0.0624954569902853 386 1234709 SGTC_2381 9035592 200 µM 1.53319836973152 0.0622388766296623 no 240 0.06261349291919 333 4749657 SGTC_3304 9125678 46.087 µM 1.52995420073474 0.0626284254431036 no 241 0.0630140329074034 439 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_576 1073-0113 22.7 µM 1.5240284522102 0.063344872221641 no 242 0.0637508019373923 582 5439563 SGTC_1467 k284-1082 293 µM 1.52359243562598 0.0633978393484663 no 243 0.0638052769778003 407 3334705 SGTC_367 0335-0881 7.1 µM 1.52149624357294 0.0636529653675952 no 244 0.0640676766334357 452 23828853 SGTC_1256 0570-0116 285 µM 1.51265081185924 0.064738342640225 no 245 0.0651841900409471 386 410638 SGTC_2451 5856223 45.7 µM 1.51249046326546 0.0647581499926648 no 246 0.0652045684642079 399 2179896 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.51113542840106 0.0649257211088234 no 247 0.0653769749256207 401 6710655 SGTC_387 norethindrone acetate 66.7 µM 1.50631392012008 0.0655247063579907 no 248 0.0659933031855515 377 541197 SGTC_567 1080-0542 68.4 µM 1.49773374970501 0.0666012249447892 no 249 0.0671012197632725 379 5950415 SGTC_948 3448-0295 75.3 µM 1.49676705992675 0.0667233646224792 no 250 0.0672269400840382 478 678569 SGTC_1450 4112-4260 37.6 µM 1.49457462252559 0.0670010178110315 no 251 0.0675127466543401 433 1633175 SGTC_3022 9087993 49.47 µM 1.49452916554747 0.0670067839850958 no 252 0.067518682355302 354 17173644 SGTC_770 0389-1121 67.2 µM 1.4831097710341 0.0684675196049138 no 253 0.069022624196488 491 6753108 SGTC_2943 9068529 45.32 µM 1.48249856313225 0.0685463907649764 no 254 0.069103842818231 472 3270634 SGTC_1762 st045503 25.4615 µM 1.48207436474493 0.0686011711298765 no 255 0.0691602544929488 440 4645554 SGTC_1322 1348-1070 12 µM 1.4799690481933 0.0688735484414782 no 256 0.0694407534916637 360 6758089 SGTC_788 1182-0090 188 µM 1.47851377299301 0.0690623128428705 no 257 0.0696351566812148 565 5715185 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.47449000506668 0.0695863129372801 no 258 0.0701748534197266 475 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2929 9013348 24.6 µM 1.47292290622962 0.069791216585402 no 259 0.0703859123832509 441 2995952 SGTC_3312 9133330 71.43 µM 1.47146434405821 0.0699823456515573 no 260 0.0705827917029503 445 17617324 SGTC_606 k015-0008 38.6 µM 1.47068679372643 0.070084399796405 no 261 0.0706879196560049 473 1970475 SGTC_898 1000-0849 28.3 µM 1.45591662738929 0.0720448113483091 no 262 0.072707834291229 443 6751807 SGTC_2587 piperic acid 92.2 µM 1.4527842035467 0.0724659236952233 no 263 0.0731418395850059 417 5370536 SGTC_774 k060-0086 136 µM 1.45202239830633 0.0725686226927185 no 264 0.0732476887122468 518 5911235 SGTC_320 4092-0846 5.34 µM 1.45045941232929 0.0727796778489409 no 265 0.0734652248212839 432 1359356 SGTC_1861 st057647 17.4 µM 1.44770574749755 0.0731526572669204 no 266 0.0738496809266429 451 688668 SGTC_1610 st001799 48.1 µM 1.44660090114896 0.0733027173788761 no 267 0.0740043668412395 389 621897 SGTC_47 0149-0135 24.25 µM 1.44324538428535 0.0737599069994903 no 268 0.074475679469548 424 5239155 SGTC_1684 st024538 14.6195 µM 1.44103578532023 0.0740621532359789 no 269 0.0747872866219691 455 6732859 SGTC_2936 9038235 15.59 µM 1.44055648068736 0.0741278409818997 no 270 0.0748550113316128 445 4749415 SGTC_738 1315-0003 72.4 µM 1.44025487574342 0.0741691981459809 no 271 0.0748976514365272 476 6251474 SGTC_2202 7226349 200 µM 1.4388397388155 0.0743634822320149 no 272 0.0750979671933241 377 844334 SGTC_2256 7954252 200 µM 1.43746040500598 0.0745532246397637 no 273 0.0752936078616337 359 2972920 SGTC_1693 xanthone 101.9 µM 1.43740658642193 0.0745606354566175 no 274 0.0753012492000674 479 7020 An insecticide. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.43548099071739 0.07482616003363 no 275 0.075575040711064 467 4213774 SGTC_2159 5658611 73.75 µM 1.43332618062913 0.0751241461480871 no 276 0.0758823217363402 424 793844 SGTC_2483 5729050 27.16 µM 1.43266532212068 0.0752157165641252 no 277 0.0759767521154855 566 2865180 SGTC_3273 9137859 49.47 µM 1.43245780225216 0.0752444886513078 no 278 0.0760064231778871 400 2377234 SGTC_1086 cerivastatin 2.18 µM 1.43227805259668 0.0752694172520751 no 279 0.0760321308020618 425 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2312 7706453 155.7 µM 1.43118230156394 0.0754215177998153 no 280 0.076188987267003 464 976098 SGTC_3228 9131799 49.47 µM 1.42536244961145 0.0762332967180613 no 281 0.0770262283386528 449 17015818 SGTC_1043 0916-0009 19.3 µM 1.42432640354158 0.0763785037231796 no 282 0.077176003850247 570 3101130 SGTC_2293 7624732 200 µM 1.42183790727105 0.0767281385415858 no 283 0.0775366561084507 436 894453 SGTC_1465 k213-0056 144 µM 1.42034621835016 0.0769383041370511 no 284 0.0777534559409122 450 24048857 YMR208W ERG12 SGTC_1750 st081859 2.357 µM 1.41908800846477 0.0771159145929713 no 285 0.0779366797592621 668 5291695 SGTC_2649 anisomycin 9.56 µM 1.41255055312228 0.0780437683235341 no 286 0.0788939583094065 410 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2459 5811157 9.22 µM 1.41111564202781 0.0782485525655063 no 287 0.0791052592498815 451 2870684 YBR192W RIM2 SGTC_1410 3909-8106 77.9 µM 1.41110018170157 0.0782507612126565 no 288 0.0791075382250228 448 1039210 SGTC_3243 9134147 49.47 µM 1.40686696154363 0.0788572954621505 no 289 0.0797334210036433 446 24282180 SGTC_2370 9071495 200 µM 1.40509163728897 0.0791127207689253 no 290 0.0799970152733462 463 21791103 SGTC_3147 9097027 49.47 µM 1.40377815839525 0.0793021008140741 no 291 0.0801924599559253 496 25236841 SGTC_3275 9138069 49.47 µM 1.40293711094163 0.0794235448415273 no 292 0.0803177965979595 443 17617007 SGTC_2228 7354201 200 µM 1.39807273009371 0.080128705646833 no 293 0.0810456139439753 439 753451 SGTC_1259 0671-0132 43 µM 1.39640340285086 0.0803717858437262 no 294 0.0812965254837447 484 X1259 SGTC_912 3474-0017 2.18 µM 1.39420014119079 0.0806934677497935 no 295 0.081628587668544 498 3360550 SGTC_835 0312-0010 67.2 µM 1.39193132205414 0.0810257363685369 no 296 0.0819715979333402 447 1626196 SGTC_2492 derrusnin 100 µM 1.39115742029512 0.0811393101730151 no 297 0.0820888479513456 420 1715307 Part of coumarin class of compounds. SGTC_2424 5537928 59.2 µM 1.38380228355628 0.0822247147548964 no 298 0.0832095018213373 535 5382802 SGTC_3121 9125696 49.47 µM 1.38240967756385 0.0824314486056213 no 299 0.0834229731537828 425 1235365 SGTC_3019 9081971 49.47 µM 1.3774920458133 0.0831646077164709 no 300 0.0841800861643507 523 16451803 SGTC_1697 st025554 27.742 µM 1.37491911430313 0.0835501490985837 no 301 0.0845782613237035 457 1269519 SGTC_1180 1193-0155 285 µM 1.37484722074233 0.0835609412581543 no 302 0.0845894074977895 466 2921347 SGTC_167 3672-0051 66.205 µM 1.37428368703995 0.0836455712926583 no 303 0.0846768143365036 456 3237971 SGTC_2226 7298446 200 µM 1.3673862647078 0.0846866318202128 no 304 0.0857521326365217 426 3283010 SGTC_1061 3448-9325 110 µM 1.36527202485033 0.0850076818730516 no 305 0.0860837840917267 463 723482 SGTC_1922 5578187 25 µM 1.36420008099237 0.0851708060497016 no 306 0.0862523013605224 486 1350412 SGTC_1629 st005085 44.9 µM 1.36244282376378 0.0854387257656426 no 307 0.0865290883905044 511 24207091 SGTC_1444 4112-3581 28 µM 1.36072442484741 0.0857013309253632 no 308 0.0868003964327459 489 2877249 SGTC_983 1491-0821 12.2 µM 1.35936659319886 0.0859092613303607 no 309 0.0870152257778102 463 46495113 SGTC_749 1000-0129 128 µM 1.35279397491146 0.0869210929616677 no 310 0.0880607290642151 553 708470 SGTC_665 3914-0008 307 µM 1.35265662771184 0.0869423316427872 no 311 0.088082676287303 492 1069549 SGTC_3196 9111891 49.47 µM 1.34975782867519 0.08739149217377 no 312 0.0885468380296193 468 18891510 SGTC_2883 9059145 45.46 µM 1.34551961697168 0.0880513050730906 no 313 0.0892287453162223 469 16476510 SGTC_522 1273-0010 11.6 µM 1.34523074949711 0.088096411354034 no 314 0.0892753645079131 497 5705015 SGTC_1377 2944-0135 198 µM 1.34193343753268 0.0886125034998132 no 315 0.0898087893959245 538 1894137 SGTC_906 1165-0455 526 µM 1.34180151662283 0.0886331983892015 no 316 0.0898301801736046 498 3252859 SGTC_1632 st005650 90 µM 1.34004033700397 0.0889098256547921 no 317 0.0901161156577508 506 2759605 SGTC_2750 bromebric acid 70.15 µM 1.33919083204567 0.0890434863767958 no 318 0.0902542781277307 587 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1765 st044815 90.4 µM 1.33853270695467 0.0891471382485344 no 319 0.0903614229162342 514 645695 SGTC_2621 lithochol-11-enic acid 100 µM 1.33327571655581 0.0899783167231224 no 320 0.0912206698208313 565 6708711 SGTC_1940 st075990 51.1 µM 1.33311230768806 0.0900042451400257 no 321 0.0912474755002012 574 1084979 SGTC_2456 5770359 74.46 µM 1.32746961795011 0.0909029914286051 no 322 0.0921766918531654 514 3118787 SGTC_2600 tangeritin 87.95 µM 1.32430443960989 0.0914100351324467 no 323 0.0927009783356738 503 68077 A bioactive flavone. SGTC_1498 4478-3555 97.6 µM 1.3226739171869 0.0916720523523766 no 324 0.0929719205304562 465 3437919 SGTC_2690 usnic acid 100 µM 1.31973814373951 0.0921452194589955 no 325 0.0934612300581233 614 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2026 5148700 152 µM 1.31888004743384 0.0922838622009427 no 326 0.0936046087868929 551 79838 SGTC_2166 5933061 31.504 µM 1.31578572919645 0.0927850938631848 no 327 0.0941229852147217 523 2877375 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.3154860189546 0.0928337490162777 no 328 0.0941733065294983 582 1273210 SGTC_1159 4092-0538 61.2 µM 1.3147286145142 0.092956790613952 no 329 0.0943005630931817 581 717301 SGTC_2484 5809818 12.04 µM 1.31377140308301 0.0931124635914321 no 330 0.0944615719299177 531 2870548 SGTC_334 1502-1024 68.5 µM 1.31303973678175 0.093231585630338 no 331 0.0945847793065817 543 3296216 SGTC_908 3448-7491 47.7 µM 1.3057354956612 0.0944269623261924 no 332 0.0958212612998651 641 1203031 SGTC_130 0136-0219 337.655 µM 1.3050529555355 0.0945392382812052 no 333 0.0959374081983179 554 234244 SGTC_3051 9093778 49.47 µM 1.30399591121465 0.09471331332521 no 334 0.0961174882379402 454 17217378 SGTC_1113 artemisinin 1.17947 µM 1.30399178407628 0.0947139934488577 no 335 0.0961181918316314 560 2240 An anti-malaria and mitochondrial poison. SGTC_2724 maprotiline 69.64 µM 1.30358031736707 0.0947818183649315 no 336 0.0961883575994702 541 4011 A tricyclic antidepressant. SGTC_2972 9093619 59.92 µM 1.30077156678776 0.0952457605154701 no 337 0.0966683285743905 519 25236256 SGTC_3113 9123498 49.47 µM 1.29818818531689 0.0956739510765123 no 338 0.0971113384895072 528 8897275 SGTC_215 1287-0124 461.5 µM 1.29688545664161 0.0958904123129593 no 339 0.0973353006114059 463 5560863 SGTC_837 0091-0265 12.5 µM 1.29627890134371 0.0959913202771562 no 340 0.0974397074005515 579 759367 SGTC_3115 9123671 49.47 µM 1.29507578398107 0.0961917047226198 no 341 0.0976470438615394 542 3286988 SGTC_2984 9022109 38.96 µM 1.29472897162259 0.0962495248900605 no 342 0.0977068709932853 487 6459207 SGTC_1896 st058441 89 µM 1.28961314976427 0.0971053987064698 no 343 0.098592503878216 516 688759 SGTC_2789 5281112 71.43 µM 1.28794817979957 0.0973851483666733 no 344 0.098882001217201 552 765948 SGTC_209 4077-0173 175.592 µM 1.28766760798219 0.0974323484302896 no 345 0.0989308469298402 434 15993494 SGTC_1366 1683-0113 21.9 µM 1.28626649566076 0.0976683060413101 no 346 0.0991750355938546 532 708623 SGTC_402 epigallocatechin gallate 10 µM 1.28529974756593 0.0978313576303147 no 347 0.0993437791822125 587 65064 An antioxidant. SGTC_2959 9079155 11 µM 1.2838744092609 0.0980721187928454 no 348 0.0995929513295562 483 16189457 SGTC_1795 st049545 62.3 µM 1.28341847317541 0.0981492248526038 no 349 0.0996727526471623 530 5291882 SGTC_1458 k015-0034 6.33 µM 1.28292650453263 0.0982324743973412 no 350 0.0997589130437283 519 3598957 SGTC_3316 9136639 10.545 µM 1.27795814983198 0.0990761056019821 no 351 0.100632091424793 542 4903665 SGTC_2635 hydroquinidine 100 µM 1.27651757965985 0.0993217038991379 no 352 0.100886308240204 560 442912 An experimental heart treatment. SGTC_2001 4023502 57.655 µM 1.27447431932586 0.09967081590367 no 353 0.101247684118682 576 108941 YCR052W RSC6 SGTC_932 2857-0803 154 µM 1.27334915243001 0.0998634446080416 no 354 0.101447086061291 612 674898 SGTC_1433 4060-0023 7.6 µM 1.27263927940833 0.0999851147654576 no 355 0.101573036747907 583 3840627 SGTC_3085 9117376 49.47 µM 1.27215336036381 0.100068462255584 no 356 0.101659317566612 564 16480349 SGTC_2276 7947513 42.08 µM 1.27193845772005 0.100105339706182 no 357 0.101697493151663 515 2105100 SGTC_3185 9108267 49.47 µM 1.27099239259771 0.100267803161652 no 358 0.101865677507256 576 4910486 SGTC_1301 naphtanilide LB 4.81 µM 1.26642904676475 0.101054149062893 no 359 0.102679758547745 602 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2930 9013230 14.89 µM 1.25971864013409 0.102218622179915 no 360 0.10388543932363 619 2995857 SGTC_2880 9042983 58.44 µM 1.2596337780938 0.102233410734281 no 361 0.103900752233785 585 6464714 SGTC_152 4469-0003 551.229 µM 1.25859927214635 0.102413814913956 no 362 0.10408755503608 561 697280 SGTC_3097 9117246 49.47 µM 1.25796520919312 0.102524501481733 no 363 0.104202169341174 559 16423892 SGTC_1457 k015-0032 57.3 µM 1.25743001872196 0.102617995826072 no 364 0.104298982462315 578 4302660 SGTC_2418 pentamidine 31.67 µM 1.25725236514272 0.102649044463831 no 365 0.1043311334606 546 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_224 benfluorex 43.875 µM 1.25670144405409 0.1027453727395 no 366 0.104430882516279 476 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2588 indole-3-carbinol 100 µM 1.25614759503076 0.10284227916517 no 367 0.104531231336253 623 3712 Induces cell cycle arrest. SGTC_1130 3454-2858 15.9 µM 1.25141497796907 0.10367304993609 no 368 0.105391557744629 578 715628 YIL048W NEO1 SGTC_1380 2291-0730 164 µM 1.24232205267491 0.105282879717051 no 369 0.107058881003307 540 2999191 SGTC_216 k038-0035 28.382 µM 1.24132259207353 0.105460923419673 no 370 0.107243301025236 541 4444231 YPR107C YTH1 SGTC_1552 6-methylflavone 10.6 µM 1.23619105391032 0.106378484427766 no 371 0.108193777631996 531 689013 SGTC_2349 9023730 187.07 µM 1.22777321170754 0.10789612396186 no 372 0.109766057219295 579 4126287 SGTC_1430 4049-0248 69.1 µM 1.22774169128138 0.107901835882253 no 373 0.109771975246033 660 22774488 SGTC_860 0443-0016 25.1 µM 1.22482943557442 0.108430515253786 no 374 0.110319745919455 596 5337942 SGTC_1312 1218-2183 165 µM 1.22446553055187 0.108496707899869 no 375 0.110388330905413 623 6744073 SGTC_1172 0370-0043 85 µM 1.22319737288326 0.108727607095567 no 376 0.110627578807274 571 376585 SGTC_3229 9132204 49.47 µM 1.2190019996818 0.109493995422115 no 377 0.111421716754622 545 17682924 SGTC_1497 4476-2978 41.3 µM 1.21714229951041 0.109834953636313 no 378 0.111775039598627 657 1528379 SGTC_3102 9121669 49.47 µM 1.2171338737259 0.10983650015533 no 379 0.111776642227772 558 41905072 SGTC_1829 berberine 14.4 µM 1.21497501858398 0.110233264528251 no 380 0.112187809732289 585 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2333 9017922 200 µM 1.21158363108022 0.110858623399356 no 381 0.112835901784901 620 3163164 SGTC_181 1447-1644 8.07 µM 1.21118791362509 0.110931757438357 no 382 0.112911696925664 610 534600 SGTC_1112 tnp00069 1.16933 µM 1.20602708314341 0.111888715932095 no 383 0.113903523955609 675 145826 SGTC_249 wiskostatin 11.211 µM 1.20490754980095 0.112097084807251 no 384 0.114119496865763 630 2775510 A n-wasp and actin depolymerizer. SGTC_467 ro 31-8220 72.8 µM 1.20402649069002 0.112261263520682 no 385 0.114289669905282 646 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1787 fluconazole 80 µM 1.20390658594502 0.112283620142318 no 386 0.1143128429883 660 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_185 k048-0037 25.491 µM 1.2038717784793 0.112290110701001 no 387 0.114319570590408 650 6827589 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.20304455003746 0.112444443148848 no 388 0.114479540637086 530 279621 SGTC_569 4130-2812 160 µM 1.20270519249347 0.112507799438999 no 389 0.114545211920577 491 743552 SGTC_2597 laccaic acid a 100 µM 1.20246045074556 0.112553507275697 no 390 0.114592590125488 645 5491415 A textile dye. SGTC_1387 3342-1166 1.8 µM 1.20037622573646 0.112943293511599 no 391 0.114996628921137 541 3418228 SGTC_1844 rapamycin 4 nM 1.19802445012015 0.113384272232249 no 392 0.115453749290154 735 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3120 9124077 49.47 µM 1.19635215040559 0.113698589381992 no 393 0.11577958282995 638 18774327 YGL155W CDC43 SGTC_1667 st014849 34.6 µM 1.19482786219714 0.113985627664755 no 394 0.116077146020699 651 5348460 SGTC_3141 9094609 49.47 µM 1.19089183501243 0.114729206604682 no 395 0.116848025154222 589 25236309 YDL196W YDL196W SGTC_530 4358-1714 28 µM 1.1899817745649 0.114901621837278 no 396 0.117026777733546 684 1564641 SGTC_1747 st037496 66.6 µM 1.18857845408562 0.115167848582038 no 397 0.117302795265134 659 723305 SGTC_2332 7982454 138.89 µM 1.18740096705712 0.11539157014527 no 398 0.117534749369024 648 2981748 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.18714140055096 0.115440929086205 no 399 0.117585925231841 616 2724278 An inhibitor of dopamine biosynthesis. SGTC_1247 0448-0043 5.84 µM 1.18542367650074 0.115767948188641 no 400 0.117924987527403 671 3089013 YGL099W LSG1 SGTC_393 acivicin 6.25 µM 1.18445488441613 0.115952676054859 no 401 0.118116522603207 568 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2990 9074105 71.4286 µM 1.18260290793084 0.116306390439465 no 402 0.118483279755342 585 6502001 SGTC_635 k038-0028 24.7 µM 1.18195775250803 0.116429790171814 no 403 0.118611232285557 651 4035102 SGTC_966 1300-0360 30.2 µM 1.18111212134023 0.116591675773443 no 404 0.118779092632865 638 70588 SGTC_1101 ebselen 5.29 µM 1.17940319879767 0.116919314896324 no 405 0.119118830996065 685 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1758 st042942 75.2445 µM 1.17866116936138 0.117061781729649 no 406 0.119266561832336 644 669317 SGTC_690 glyoxal 20.3 µM 1.17536821801447 0.117695499929975 no 407 0.119923716465896 650 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2679 rapamycin 1 nM 1.17061868295638 0.118613803742353 no 408 0.120876042084265 734 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1389 3405-0187 19 µM 1.16994212095665 0.118745025161747 no 409 0.121012130862709 585 799890 SGTC_752 1896-0090 130 µM 1.16640841549945 0.119432065547015 no 410 0.121724678829597 650 772567 SGTC_162 k030-0015 37.8 µM 1.16497589001189 0.11971138161963 no 411 0.122014376145828 668 1809920 YMR134W ERG29 SGTC_2904 7225135 42.03 µM 1.16473508098688 0.119758380133773 no 412 0.122063122066168 675 4446116 SGTC_1884 5633444 25 µM 1.16455749631301 0.119793047533918 no 413 0.122099078517087 665 5724239 SGTC_1499 4480-0877 67.3 µM 1.16319611824803 0.120059045607043 no 414 0.122374970557618 606 2861909 SGTC_1953 st076800 12.1 µM 1.16259196905031 0.120177222872207 no 415 0.122497545347985 659 297591 SGTC_24 0417-1663 219 µM 1.16076856717604 0.120534394355301 no 416 0.122868014503242 633 4329390 SGTC_281 1672-3440 14.9 µM 1.15885037341209 0.120910939955633 no 417 0.123258590197692 713 6833000 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.15730738836566 0.121214431423457 no 418 0.123573398004199 663 5377381 SGTC_1759 st043059 70 µM 1.15708658777785 0.121257904721044 no 419 0.123618492897497 679 669426 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.15653767763955 0.121366026823224 no 420 0.123730648707072 548 1241132 A phosphatase inhibitor. SGTC_1713 st033146 12.748 µM 1.15457376855923 0.121753424770871 no 421 0.124132506871202 670 674619 SGTC_3110 9122132 49.47 µM 1.15237741083171 0.122187703452666 no 422 0.124583009654007 669 918317 SGTC_3189 9110682 49.47 µM 1.15144587677343 0.12237222070896 no 423 0.124774424686052 648 17122418 SGTC_102 gallobenzophenone 83.616 µM 1.15084843421553 0.12249066436748 no 424 0.124897297492524 667 70837 SGTC_479 n-linoleoylglycine 10 µM 1.1506175461326 0.12253645973374 no 425 0.12494480564673 622 6433346 An anti-infammatory. SGTC_1873 rapamycin 2 nM 1.14802452431633 0.123051596326043 no 426 0.125479219922086 703 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2255 7941087 197.44 µM 1.14615529787833 0.123423882155751 no 427 0.125865450226632 743 935561 SGTC_3349 9149703 23.001 µM 1.14583275250169 0.123488201874967 no 428 0.125932180194431 632 4910494 SGTC_2077 5212015 200 µM 1.14452089939082 0.123750044264969 no 429 0.126203837811563 621 780900 SGTC_1114 scopoletin 1.73284 µM 1.1438998995095 0.123874129646344 no 430 0.126332576366702 664 5280460 A coumarin with genotoxic properties. SGTC_2878 9043973 25.97 µM 1.14109226891631 0.124436224512063 no 431 0.126915764082607 636 6465167 SGTC_2190 6049624 200 µM 1.14090670456664 0.124473437703504 no 432 0.126954374544501 600 2265554 SGTC_809 3998-0021 90 µM 1.14041377304059 0.124572328287855 no 433 0.127056978742867 648 715485 SGTC_1023 4482-3888 16 µM 1.14031121483557 0.12459291013686 no 434 0.12707833358794 665 3303168 SGTC_2949 9072542 2.23 µM 1.13561821396484 0.125537267059798 no 435 0.12805819132337 681 16457352 SGTC_1144 3486-0183 12.5 µM 1.13499154491313 0.125663746615872 no 436 0.128189430503367 718 6744069 SGTC_3198 9112019 49.47 µM 1.13320518851647 0.126024771733966 no 437 0.128564047905392 653 45595555 SGTC_3143 9086658 49.47 µM 1.13199560211087 0.126269641078464 no 438 0.128818141688297 753 25236626 SGTC_2875 9039966 71.43 µM 1.13092565918263 0.126486517127333 no 439 0.12904319121322 635 6463691 SGTC_21 0849-0113 22.993 µM 1.13002796359729 0.126668678952349 no 440 0.129232220807178 686 1560156 SGTC_3053 9095903 49.47 µM 1.12972508910874 0.126730179927385 no 441 0.129296040989388 670 17174018 SGTC_3092 9117248 49.47 µM 1.12893113254535 0.126891497547821 no 442 0.129463443178779 733 17141857 SGTC_2947 9072639 7.68 µM 1.12867148186603 0.126944284876835 no 443 0.129518221934999 719 16488146 SGTC_1706 st031321 9.9705 µM 1.12675649961247 0.127334075410157 no 444 0.129922723546475 695 6103185 SGTC_2095 5432005 200 µM 1.12615535764419 0.127456608078164 no 445 0.130049882908386 641 783734 SGTC_1297 1068-0111 14.1 µM 1.12451942713863 0.127790480086985 no 446 0.130396366828563 661 767057 SGTC_3070 9117005 49.47 µM 1.11835732845396 0.129053538212141 no 447 0.131707205673434 634 8779016 SGTC_1320 1313-0481 95.3 µM 1.11798497728446 0.129130136170794 no 448 0.131786704758875 708 6813365 YLR208W SEC13 SGTC_2673 kobusone 100 µM 1.11571935047635 0.129596887346661 no 449 0.132271142478702 692 6710676 An epoxy ketone and protein crosslinker. SGTC_2373 9071805 200 µM 1.11545180327566 0.129652082910255 no 450 0.132328430518924 703 10149009 SGTC_1720 st037298 9.481 µM 1.1124660475753 0.130269155589736 no 451 0.132968910248003 657 597396 SGTC_2231 micatex 6.853 µM 1.11150274724322 0.130468675816559 no 452 0.133176004095567 660 20737 An antifungal of unknown mechanism. SGTC_2413 inermin 26.06 µM 1.1086125797817 0.131068559541819 no 453 0.133798674457103 729 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2872 9044037 25.97 µM 1.10650496972852 0.131507215154713 no 454 0.134254007082762 650 6465195 SGTC_3324 9138759 60.749 µM 1.10621412629907 0.131567827701634 no 455 0.134316924990323 690 45595710 SGTC_1726 st035556 14.5795 µM 1.10382756829748 0.13206592103992 no 456 0.134833971805997 758 5919439 SGTC_1236 0330-0013 258 µM 1.09822066372531 0.133241237210673 no 457 0.13605407262077 678 4617066 SGTC_2287 7945887 168.79 µM 1.09749499495772 0.133393875883412 no 458 0.13621253373582 755 1245853 SGTC_2072 5231554 129 µM 1.09499640163194 0.133920355062152 no 459 0.136759106468309 731 789545 SGTC_3171 9103192 49.47 µM 1.09381787516568 0.134169177619905 no 460 0.137017431386563 698 13018434 SGTC_3067 9117431 49.47 µM 1.09112356557117 0.13473922013673 no 461 0.137609257377984 652 17150885 SGTC_2858 9025781 8.96 µM 1.08992632556553 0.134993056066519 no 462 0.137872799534264 812 4894980 YPL153C RAD53 SGTC_44 0929-0055 61.211 µM 1.0825440436469 0.136565474453145 no 463 0.139505427933633 657 1379590 SGTC_812 4251-0442 148 µM 1.080713190914 0.136957374885077 no 464 0.139912356789654 707 5723007 SGTC_2394 5221648 200 µM 1.07776993765371 0.137588998035951 no 465 0.140568219280203 819 788586 SGTC_3352 9151559 45.5865 µM 1.0762527499175 0.137915362474633 no 466 0.14090711704781 696 17159339 SGTC_1990 st072050 59.8 µM 1.07574791117821 0.138024076063933 no 467 0.141020006852473 739 17233948 SGTC_1691 st019933 84.6 µM 1.07541760955191 0.138095235894083 no 468 0.141093900627286 719 6176082 SGTC_1895 st058434 18.3 µM 1.07363895245033 0.138478857945374 no 469 0.141492266115138 752 5393175 SGTC_2889 9059656 51.95 µM 1.07362146321613 0.138482633637987 no 470 0.141496186955692 767 3949838 SGTC_1085 doxorubicin 7.67 µM 1.07135218965687 0.138973134709654 no 471 0.142005550780079 778 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2432 5630864 12.22 µM 1.07117731631832 0.139010982422176 no 472 0.14204485450569 709 5714970 SGTC_2294 7971431 200 µM 1.07062656141585 0.139130227762412 no 473 0.142168687752206 654 5741572 SGTC_992 3909-8734 162 µM 1.06681992083464 0.13995631650666 no 474 0.143026580605019 718 4288319 SGTC_1927 st060202 13.8 µM 1.06633765312949 0.140061212052442 no 475 0.143135517163279 731 688887 SGTC_3223 9129970 49.47 µM 1.06508869059683 0.14033311565751 no 476 0.143417898299437 772 17248386 SGTC_2726 cimetidine 79.27 µM 1.06243227178631 0.140912618853856 no 477 0.144019744846534 659 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2243 6634756 200 µM 1.0616526656214 0.141082999216142 no 478 0.14419669768412 710 885676 SGTC_2031 5180455 200 µM 1.0604112517258 0.141354594379955 no 479 0.144478772774552 704 29949 SGTC_3301 9125354 19.7965 µM 1.0603777678147 0.141361924857938 no 480 0.144486386162476 670 41905162 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.05999277530462 0.141446228002376 no 481 0.144573943069005 796 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2810 7959871 45.46 µM 1.05861695804999 0.141747773866094 no 482 0.14488713032596 789 2974535 SGTC_3247 9135149 49.47 µM 1.05593628428817 0.142336562581025 no 483 0.145498662776489 696 8934436 YOR116C RPO31 SGTC_2272 7805186 180 µM 1.05101015635975 0.14342285621756 no 484 0.146626962617499 765 2956062 YPR165W RHO1 SGTC_2321 7390090 138.78 µM 1.04981299789152 0.14368769291376 no 485 0.146902049041369 672 649046 SGTC_2945 9067681 61.76 µM 1.04905921775302 0.143854614181141 no 486 0.14707543223359 727 16456930 SGTC_753 1322-0200 289 µM 1.04748940173964 0.144202662731466 no 487 0.147436958849525 773 5403907 SGTC_3206 9114350 49.47 µM 1.04550695806359 0.144643006711905 no 488 0.147894363205391 703 17087243 SGTC_3082 9117008 49.47 µM 1.04474064338928 0.144813464397741 no 489 0.148071427422799 762 41448529 SGTC_2913 7966556 36.57 µM 1.04355047566553 0.145078471301599 no 490 0.14834670804394 734 2976516 SGTC_29 0299-0004 12.984 µM 1.04286699774621 0.145230804336686 no 491 0.148504948157367 645 16871 A napthoquinone isolated from Swertia calycina. SGTC_2170 morpholine 200 µM 1.0391418790992 0.146062947273768 no 492 0.149369378197514 774 121171 Reacts with secondary amines. SGTC_1617 st002906 78 µM 1.03905599570513 0.146082170204791 no 493 0.149389347349043 782 5150859 SGTC_1074 carmofur 3.8 µM 1.03823122208707 0.146266862459731 no 494 0.149581210074014 832 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3088 9117578 49.47 µM 1.03748843991183 0.146433328447218 no 495 0.149754140229359 763 678341 SGTC_1937 st074714 47.2 µM 1.03401871677282 0.147212617340537 no 496 0.150563706672117 740 17250970 SGTC_3103 9120822 49.47 µM 1.03329110862745 0.147376387807518 no 497 0.150733843480815 789 17141819 SGTC_924 2046-0044 21.3 µM 1.0331062656904 0.147418011804277 no 498 0.1507770857374 776 3623589 SGTC_234 nsc-17383 10.7 µM 1.02977972877812 0.148168447071683 no 499 0.151556709340844 820 408974 SGTC_903 1134-0042 114 µM 1.02814470995834 0.148538227158212 no 500 0.15194088098501 755 701009 SGTC_1674 st016616 23.6 µM 1.02781568607592 0.148612714567703 no 501 0.152018268089832 754 625830 SGTC_3268 9137683 49.47 µM 1.02416879387872 0.149440003341258 no 502 0.152877777771269 751 1953228 SGTC_1852 st056254 31.4 µM 1.0238280993281 0.149517445784311 no 503 0.152958237869516 753 442583 SGTC_1909 st060837 51.5 µM 1.02131752582947 0.150088943886154 no 504 0.153552012829191 732 678937 SGTC_66 0109-0187 42.4 µM 1.02095065594748 0.150172578643407 no 505 0.153638908767508 713 759417 SGTC_3267 9137951 49.47 µM 1.02068150469236 0.150233956388284 no 506 0.153702680003378 753 16643986 SGTC_2951 9072950 58.06 µM 1.01869834576632 0.150686714971795 no 507 0.154173099089999 858 16488155 SGTC_1003 4049-0218 100 µM 1.01739337216317 0.150985137833225 no 508 0.154483166856741 797 295161 SGTC_1254 0550-0035 264 µM 1.01595830759105 0.151313763839189 no 509 0.154824620427561 837 15121435 SGTC_3191 9110352 49.47 µM 1.01513306886987 0.151502956613638 no 510 0.155021200068918 757 17122424 SGTC_131 0141-0277 33.849 µM 1.01261777781085 0.152080577657246 no 511 0.155621382458825 787 1547771 SGTC_1127 asiatic acid 681.4 nM 1.01034120178635 0.152604638577513 no 512 0.156165923842304 755 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_846 0335-0850 148 µM 1.00648105622202 0.15349596736413 no 513 0.15709210990625 782 6819598 SGTC_2051 5263410 176 µM 1.00509911789394 0.15381590097582 no 514 0.157424562407437 819 227584 SGTC_3220 9131269 49.47 µM 1.00348448610963 0.154190264353465 no 515 0.157813579261094 789 17722206 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.00094408528507 0.154780492594608 no 516 0.158426920764898 781 803109 SGTC_1985 st071382 65.5 µM 0.998712814826337 0.155300128172197 no 517 0.158966915514537 813 6123237 SGTC_2131 toluylene red 5.2905 µM 0.997227319999203 0.15564671944366 no 518 0.159327091424667 785 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1369 1866-0067 208 µM 0.995891594112778 0.155958802339144 no 519 0.159651409986658 867 3531355 SGTC_3156 9099931 49.47 µM 0.995366709636172 0.156081550687636 no 520 0.159778971787096 858 18111053 SGTC_2465 5809242 33.21 µM 0.995315385171564 0.156093556732004 no 521 0.159791448664179 822 2731748 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.992769504200787 0.156689864194237 no 522 0.16041114730658 777 4330530 SGTC_1299 1079-1439 3.74 µM 0.992424123586399 0.156770876116085 no 523 0.1604953379918 761 323161 SGTC_332 4112-0506 40.9 µM 0.991314587284441 0.157031313646556 no 524 0.160765996123503 809 2790355 SGTC_1173 0443-0020 122 µM 0.987441647333562 0.157942624317447 no 525 0.161713087992397 799 5331295 SGTC_1640 st009078 66.4 µM 0.987165692366587 0.158007689346719 no 526 0.161780708742338 751 690618 SGTC_232 clozapine 119 µM 0.98694042493042 0.158060816246211 no 527 0.161835922541011 811 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2657 nystatin 74.44 µM 0.986753723371593 0.158104856684293 no 528 0.161881693018765 831 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1604 st002052 72.4 µM 0.98488448161179 0.158546230155364 no 529 0.16234040841357 807 6254834 YHR062C RPP1 SGTC_754 3474-0146 171 µM 0.984364876791879 0.158669064894312 no 530 0.162468070541441 752 24762078 SGTC_3046 9092212 49.47 µM 0.982542533937421 0.159100360343571 no 531 0.162916319640178 814 25236637 SGTC_2450 5739737 12.93 µM 0.980257869468921 0.159642157823561 no 532 0.163479422737347 756 2262825 SGTC_2102 5377816 72.7585 µM 0.979692315662513 0.159776462477959 no 533 0.163619010191266 857 1379702 SGTC_1055 3448-0672 86 µM 0.977991695692619 0.16018076170513 no 534 0.164039215649294 791 748378 SGTC_2521 angolensin 13.4 µM 0.976875869783955 0.160446397153033 no 535 0.164315304627789 788 821428 A flavenoid. SGTC_3135 9127742 49.47 µM 0.9763331838657 0.160575693874981 no 536 0.164449690324411 764 3643468 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.975640546944719 0.160740815761222 no 537 0.164621311953623 787 75037 A free radical scavenger. SGTC_3347 9188721 44.724 µM 0.974883589142109 0.160921398243307 no 538 0.164809003691311 794 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1975 st070967 30.8 µM 0.973582025081727 0.161232213382079 no 539 0.165132057411454 907 261391 SGTC_930 2810-3379 265 µM 0.972580534642098 0.161471636988166 no 540 0.165380910442383 902 1015764 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.972452771607807 0.161502197616011 no 541 0.165412674786293 901 688788 SGTC_2214 7179297 48.276 µM 0.971812503828825 0.161655405016284 no 542 0.16557191709984 839 769744 SGTC_2733 amorolfine 100 µM 0.971360703487987 0.161763571704224 no 543 0.165684344936121 777 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2268 7933382 153.85 µM 0.970522544597058 0.161964362374959 no 544 0.165893046506012 935 935025 YOR257W CDC31 SGTC_2830 7992007 71.43 µM 0.970038847786211 0.162080311398976 no 545 0.166013564303387 778 1952075 SGTC_671 0560-0003 407 µM 0.968400362552 0.16247348129118 no 546 0.166422229240168 808 3238678 SGTC_3122 9126309 49.47 µM 0.966206405033376 0.16300091307514 no 547 0.166970454255106 885 17591206 SGTC_2191 5911152 200 µM 0.965022063723365 0.163286093177676 no 548 0.167266880394914 844 2875902 SGTC_246 cycloheximide 667 µM 0.957492807499726 0.165106654855151 no 549 0.169159287502083 741 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2731 amoxapine 43.43 µM 0.955622599908122 0.165560897517088 no 550 0.169631469664942 801 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1508 1080-0625 72.9 µM 0.954232773926568 0.16589898640124 no 551 0.169982914178014 805 767111 SGTC_1245 0418-0076 17.2 µM 0.953456980761288 0.166087899665168 no 552 0.170179291394709 843 6790114 SGTC_1957 st077035 62.4 µM 0.950371520414251 0.166840614590016 no 553 0.170961754839669 874 705593 SGTC_989 1501-0895 10.3 µM 0.94982897356089 0.166973199014125 no 554 0.171099580654051 878 2830112 SGTC_2720 fluspirilene 36.88 µM 0.949123258401494 0.167145759203342 no 555 0.171278963211272 777 3396 An atypical antipsychotic. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.946909133129829 0.167687899022836 no 556 0.171842541798057 791 2374 Ca(2+)-ATPase inhibitor. SGTC_3331 9141060 1.957 µM 0.946828796972337 0.167707591005631 no 557 0.171863012626051 812 4906567 YPR165W RHO1 SGTC_2822 7994718 71.43 µM 0.944787692859376 0.168208405559156 no 558 0.172383638141346 770 1018011 SGTC_2727 riluzole 51.77 µM 0.944282942396257 0.16833240165162 no 559 0.172512540106738 805 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_305 1682-2595 20.8 µM 0.943666780788169 0.168483846469879 no 560 0.17266997727946 886 226033 SGTC_2160 5660466 132.927 µM 0.942982012292537 0.168652256751053 no 561 0.172845051819207 827 2859134 SGTC_2681 menadione 3.18 µM 0.942942191082222 0.168662053609537 no 562 0.172855236374614 855 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2544 sphondin 68.51 µM 0.941155869323265 0.169101902681833 no 563 0.173312494092286 835 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1241 0364-0022 50.8 µM 0.940093244827856 0.169363903642572 no 564 0.17358486676499 873 4563895 SGTC_1269 0831-0796 3.05 µM 0.938354757121433 0.16979310709342 no 565 0.174031064171685 881 927758 SGTC_2821 7996764 71.43 µM 0.936796825780244 0.170178326276955 no 566 0.174431539206335 896 2987135 SGTC_1701 st028638 40.4 µM 0.936248752669674 0.170313977675978 no 567 0.1745725635731 891 3490878 SGTC_2010 4012422 159 µM 0.93094004928008 0.171631497013714 no 568 0.175942288156941 874 952393 SGTC_1685 st024049 53.0905 µM 0.930664816390728 0.171699981673564 no 569 0.17601348742167 858 1941139 SGTC_1778 st046819 58.9 µM 0.930388216057501 0.171768824170691 no 570 0.176085058802976 933 671715 SGTC_3066 9117245 49.47 µM 0.927757966048956 0.172424342464478 no 571 0.176766566267415 924 17176980 SGTC_1826 st055655 41.6 µM 0.927535567243358 0.17247984238888 no 572 0.176824266972687 877 676168 SGTC_1527 coumarin 137 µM 0.923859738842331 0.173398800319206 no 573 0.177779673674221 826 323 A hepatotoxic, DNA x-linker. SGTC_1102 cgs 12066b 26.1 µM 0.923511566247806 0.173486004845195 no 574 0.177870337839807 854 6438352 A 5-HT1B full agonist. SGTC_2835 9006588 71.43 µM 0.923328497918811 0.173531867973946 no 575 0.177918020540081 809 2345538 SGTC_1782 st039423 80.636 µM 0.923199583234817 0.173564168909264 no 576 0.177951603004671 814 2068169 SGTC_88 0180-0332 8.668 µM 0.917601658866777 0.174970477164286 no 577 0.179413724552697 949 3101745 SGTC_60 0986-0278 202 µM 0.91673162980548 0.175189692901646 no 578 0.179641643654634 787 3110598 SGTC_3221 9128209 49.47 µM 0.916572061845466 0.175229917129935 no 579 0.179683464967069 850 16460723 SGTC_970 1315-0089 19.5 µM 0.913749088777217 0.175942506333761 no 580 0.18042435177784 846 6811083 YLR033W RSC58 SGTC_1234 0326-0494 15.5 µM 0.913730264048647 0.175947264318172 no 581 0.180429298735254 899 1547813 SGTC_2068 5226020 147 µM 0.912711308428178 0.176204928766264 no 582 0.180697197412122 947 1810509 SGTC_1608 st001473 40.5 µM 0.911957541044566 0.176395688361549 no 583 0.180895534534705 846 7292267 SGTC_2313 7726885 200 µM 0.90971168436038 0.176964832499486 no 584 0.181487290251423 863 726423 SGTC_3192 9110362 49.47 µM 0.908706079870271 0.177220048094995 no 585 0.181752647011813 928 16649480 SGTC_2630 antimycin a 100 µM 0.907751029974809 0.177462648388526 no 586 0.18200488814099 944 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_73 0327-0325 16.231 µM 0.905159690806515 0.178121951816208 no 587 0.182690396594743 991 53298 SGTC_1865 st057639 52.2 µM 0.90407202186913 0.178399142279927 no 588 0.182978606378182 935 688818 SGTC_1853 st056710 91.2 µM 0.902479344109273 0.178805523367286 no 589 0.183401144626794 972 269167 SGTC_2436 5633522 8.09 µM 0.901536062193501 0.179046481832352 no 590 0.183651684405676 942 5724242 SGTC_3329 9141233 27.5565 µM 0.897198816472521 0.180157045473375 no 591 0.184806418321658 899 4909101 YNL103W MET4 SGTC_147 4466-0538 29.23 µM 0.896971764616757 0.180215301579654 no 592 0.18486699190551 961 6742687 YHR072W ERG7 SGTC_1679 SEC14.276 6.7 µM 0.896881063440755 0.180238576648845 no 593 0.18489119288951 954 1005053 YMR079W SEC14 SGTC_3239 9133757 49.47 µM 0.895100345494441 0.180695913453078 no 594 0.185366724649264 936 17036923 SGTC_2141 5621638 7.665 µM 0.894046828349254 0.180966827573633 no 595 0.185648418265755 928 2856238 SGTC_3342 9147791 14.508 µM 0.893978415130064 0.180984428971485 no 596 0.185666720044454 937 1838168 SGTC_427 1354-0053 47.3 µM 0.892702903752971 0.181312789801716 no 597 0.186008147471274 895 6813657 SGTC_1188 1403-0014 4.57 µM 0.892413809608268 0.181387264478445 no 598 0.186085585938625 957 9614867 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.891594372890542 0.181598466849734 no 599 0.186305193685515 926 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_170 4197-0004 226 µM 0.886815355628302 0.182833279103977 no 600 0.187589159465726 856 218692 SGTC_524 r073-0010 27.8 µM 0.885250209899958 0.183238821256646 no 601 0.188010848693043 890 2772106 SGTC_2611 pyromycin 23.93 µM 0.878260132164283 0.185056847212643 no 602 0.189901283010258 906 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3288 9119690 36.221 µM 0.877930819534684 0.185142772527467 no 603 0.189990631396015 862 17595618 YKL019W RAM2 SGTC_2683 piperine 63.03 µM 0.875361695635558 0.185813967129439 no 604 0.19068856731864 908 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2992 9074591 71.4286 µM 0.874156585959594 0.186129326521783 no 605 0.191016492518957 910 17741321 SGTC_2317 5986382 200 µM 0.872848228472876 0.186472079685773 no 606 0.191372904041253 971 877883 SGTC_1321 1326-2144 215 µM 0.871553046888112 0.186811765902004 no 607 0.191726127420107 960 3513030 SGTC_725 1497-0963 19 µM 0.869896094529916 0.187246891416501 no 608 0.192178594977989 981 3549977 SGTC_3241 9133421 49.47 µM 0.869552861554734 0.187337104722905 no 609 0.19227240395698 969 17018221 SGTC_985 1493-0307 8.71 µM 0.86897763393425 0.18748835435514 no 610 0.192429682163328 921 3278274 SGTC_1963 st076565 50.3 µM 0.864654652658636 0.188627446959079 no 611 0.193614182980364 942 4914280 SGTC_2719 novobiocin 32.65 µM 0.863156906968673 0.189023091539309 no 612 0.194025601597027 921 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2177 5811945 192 µM 0.861838906478194 0.189371677118227 no 613 0.194388085916202 972 5343475 SGTC_655 k060-0012 42 µM 0.857172706136829 0.190608973641214 no 614 0.19567472212595 930 5994525 SGTC_3276 9139060 49.47 µM 0.856626607086438 0.190754101739017 no 615 0.195825638115743 953 4870619 SGTC_1805 st050013 60.3 µM 0.855945582579774 0.190935181819808 no 616 0.196013940070245 938 4037144 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.855023388927154 0.191180555244609 no 617 0.196269099825832 990 165506 SGTC_489 paxilline 115 µM 0.854468724072867 0.191328231211895 no 618 0.196422665776068 941 105008 A toxic potassium channel blocker. SGTC_1108 betulinic acid 729.144 nM 0.852849140239626 0.191759834999224 no 619 0.196871484535796 962 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3074 9116018 49.47 µM 0.852726927235486 0.191792427782813 no 620 0.196905377356364 941 17027303 SGTC_1001 4048-4355 44.4 µM 0.852213202513483 0.191929469268885 no 621 0.197047885111427 942 21824233 SGTC_1766 st045414 44.774 µM 0.85209140985061 0.191961967532892 no 622 0.197081679670133 1033 253960 SGTC_2712 st079126 47.7 µM 0.851021558287543 0.192247583614557 no 623 0.197378688664567 935 3152970 SGTC_2049 5262831 67.185 µM 0.850887739242957 0.192283327291999 no 624 0.197415858146009 969 763417 SGTC_3140 9094243 49.47 µM 0.847456860522099 0.193201118109345 no 625 0.198370261348948 1064 19291112 SGTC_2783 7738165 71.43 µM 0.846826690364946 0.193369984489966 no 626 0.198545864520437 874 17201110 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.8456303913201 0.193690803806776 no 627 0.198879482985197 934 4620898 SGTC_2697 mebhydrolin 72.4 µM 0.845265880704164 0.193788621468896 no 628 0.198981203181008 990 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2987 9018338 71.43 µM 0.845214970914769 0.193802285680128 no 629 0.198995412542524 987 5055682 SGTC_2982 9019404 25.97 µM 0.844692444426484 0.193942565980769 no 630 0.199141289536171 913 22333232 SGTC_1025 k007-0731 70 µM 0.844563305685273 0.193977244802776 no 631 0.199177351932972 961 6256118 SGTC_1652 st011932 78 µM 0.840986506850392 0.194939256775632 no 632 0.200177746772128 966 1551076 SGTC_2125 5246583 200 µM 0.84015193042962 0.195164140281975 no 633 0.200411603222753 1040 835267 SGTC_3130 9127414 49.47 µM 0.838679942685473 0.195561163619562 no 634 0.200824468302481 986 1494646 SGTC_3146 9095609 49.47 µM 0.837076613424137 0.195994169859993 no 635 0.201274752514283 966 17173999 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.836433552009263 0.196168002786136 no 636 0.20145552190963 1073 6708561 SGTC_2300 7976697 71.57 µM 0.835916956075904 0.196307717152011 no 637 0.201600811357431 879 2236109 SGTC_2696 st077691 74.316 µM 0.833979260820941 0.196832307822461 no 638 0.2021463353464 914 757133 SGTC_1229 0139-0193 12.2 µM 0.832562383192935 0.197216434697367 no 639 0.202545790772944 1050 3090752 SGTC_2939 9044578 71.43 µM 0.832004322114041 0.197367853935362 no 640 0.20270325244711 974 2653634 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.83182291344807 0.197417090858502 no 641 0.202754454193565 1137 688664 SGTC_625 k213-0058 121 µM 0.831557055145348 0.197489262046678 no 642 0.202829505414123 1119 3655420 SGTC_3158 9100007 49.47 µM 0.830834756268433 0.197685421344298 no 643 0.203033492595081 982 19297233 SGTC_3279 9140807 49.47 µM 0.827631400107444 0.19855679535476 no 644 0.2039396399387 1022 45595718 SGTC_2232 chlorophetanol 41.5365 µM 0.825281040070105 0.199197609261529 no 645 0.204606026720057 1103 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2701 st077767 14.721 µM 0.824976287228213 0.199280789733971 no 646 0.204692526675896 1020 5721188 SGTC_1228 0124-0032 52.5 µM 0.824759536331842 0.199339963326919 no 647 0.204754061710526 1042 X1228 SGTC_689 0833-0039 98 µM 0.824301246200647 0.199465112626413 no 648 0.204884205347293 1024 5374726 SGTC_291 SEC14.278 35.5 µM 0.823823076581838 0.199595740997772 no 649 0.205020046710979 1032 1068044 SGTC_1390 3413-2614 145 µM 0.823623713619053 0.199650219006754 no 650 0.205076698776473 1063 3421432 SGTC_3087 9117406 49.47 µM 0.821486708198581 0.200234739808025 no 651 0.205684546052436 996 42546093 SGTC_276 colchicine 750 µM 0.821431335467376 0.200249899196589 no 652 0.205700310405573 1026 2833 A microtubule depolymerizer. SGTC_1960 st011366 51.8 µM 0.821054105068684 0.200353191886746 no 653 0.205807725186751 1060 3972846 SGTC_1631 benzylvanillin 81.9 µM 0.820502978805304 0.200504158024662 no 654 0.205964715906113 983 75506 SGTC_2700 st077718 96.8 µM 0.81820278995635 0.201134969749104 no 655 0.206620701170952 954 904970 SGTC_1033 k072-0102 21.3 µM 0.817309168111534 0.201380360344927 no 656 0.206875884373473 1014 5965931 SGTC_3161 9100388 49.47 µM 0.817217480086168 0.201405548231834 no 657 0.206902077409687 1053 25236368 SGTC_2062 5245942 200 µM 0.815906433652234 0.201765916137041 no 658 0.207276826095476 1114 1376160 SGTC_944 3370-0224 231 µM 0.815660634114794 0.201833522120768 no 659 0.207347129933633 1022 4580514 SGTC_2112 5488546 200 µM 0.813648443801387 0.202387475240219 no 660 0.207923188605879 1004 600757 SGTC_2793 7325131 81.82 µM 0.809385457587918 0.203564068639628 no 661 0.209146732196902 986 4176441 SGTC_730 1436-0052 41.2 µM 0.809344212996687 0.203575472125324 no 662 0.209158590706637 1027 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1591 genipin 88.4 µM 0.80848952395852 0.203811866041129 no 663 0.209404417184121 976 442424 A DNA cross-linking agent. SGTC_3179 9107801 49.47 µM 0.807291503208105 0.20414349553198 no 664 0.209749279069438 1062 4818259 SGTC_443 clozapine 122 µM 0.804523612723643 0.204910915716922 no 665 0.210547318980455 949 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1607 st000305 50.6 µM 0.801367751518587 0.205787993426522 no 666 0.211459389342099 1029 5457690 SGTC_1737 st035557 69.7 µM 0.800895074278359 0.205919551542355 no 667 0.21159619597379 909 5716916 SGTC_1970 st070122 35.8 µM 0.800756034389844 0.205958259378898 no 668 0.211636448048252 1040 102928 SGTC_1731 st035964 63 µM 0.799594132290905 0.206281894355019 no 669 0.211972994117291 976 6739575 SGTC_909 3448-9333 149 µM 0.79446566622592 0.207713968974511 no 670 0.213462194527868 985 3344074 SGTC_104 0074-0074 590.992 µM 0.793984275860201 0.207848693436429 no 671 0.213602292688321 921 3943124 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.793913940340542 0.207868382228017 no 672 0.213622766790991 1038 442882 SGTC_1203 3992-3522 103 µM 0.793451502555236 0.207997858344856 no 673 0.213757407169613 1098 5322312 SGTC_2698 st077697 67.5 µM 0.793442869895238 0.208000275821602 no 674 0.213759921068608 988 3154499 SGTC_294 k038-0071 157 µM 0.79294364322381 0.208140106700124 no 675 0.213905329119729 1054 24152826 SGTC_2905 7799065 20.05 µM 0.790762489209397 0.208751687315049 no 676 0.214541301499112 1015 1296806 SGTC_410 α-linolenic acid 100 µM 0.790242945565873 0.20889751980412 no 677 0.214692949948193 1066 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3285 9112818 20.8695 µM 0.789083831832397 0.209223091655776 no 678 0.215031505530687 1111 17017947 YPR165W RHO1 SGTC_2969 9091408 28.7 µM 0.788798681797481 0.20930323034998 no 679 0.21511484004428 981 4286311 SGTC_3145 9085516 49.47 µM 0.782237603868643 0.211152143646558 no 680 0.217037474410605 1048 25236195 SGTC_2315 7733312 200 µM 0.782171643010863 0.211170779895663 no 681 0.217056853622358 1027 726316 SGTC_571 k831-0106 44.2 µM 0.78120685229388 0.21144347714928 no 682 0.21734042209384 1023 4783639 SGTC_1578 josamycin 24.2 µM 0.781092377505982 0.211475847028733 no 683 0.217374082380729 1006 5282165 A P450 substrate. SGTC_1570 verbenone 133 µM 0.780331269986504 0.211691138135192 no 684 0.217597955759006 1074 29025 A natural terpanoid with antifungal properties. SGTC_682 0kpi-0099 17 µM 0.778572934052322 0.212189001037713 no 685 0.218115663965387 1091 1714895 YML126C ERG13 SGTC_962 1254-0300 21.5 µM 0.777338494490914 0.212538934228173 no 686 0.218479544730164 1046 7340576 SGTC_2387 9077560 195.08 µM 0.775326110154527 0.21311011768051 no 687 0.219073492278488 1056 5303272 SGTC_1507 4075-3230 155 µM 0.7747326110369 0.213278743838324 no 688 0.219248838413251 1009 659771 SGTC_2258 7960471 200 µM 0.774454180217058 0.213357878963524 no 689 0.21933112709937 1027 2974708 SGTC_2570 licareol 100 µM 0.774399970899134 0.213373288232494 no 690 0.219347150426885 1005 443158 SGTC_3078 9116413 49.47 µM 0.774024820191746 0.213479944470968 no 691 0.219458056857607 1063 17177322 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.772832451352575 0.213819144019185 no 692 0.219810772696672 1075 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2336 9001819 198.65 µM 0.7721139320731 0.214023696505033 no 693 0.220023475644303 1100 2989602 SGTC_2355 9061122 103.12 µM 0.770956316915167 0.214353492972571 no 694 0.220366412209704 1078 5302957 SGTC_1393 3470-5649 58.2 µM 0.769922157291244 0.214648367630332 no 695 0.220673034773698 975 4108395 SGTC_2060 5238662 140 µM 0.7677006894905 0.215282581424445 no 696 0.221332513232195 1034 790130 SGTC_1786 berberine 21.6 µM 0.766957532593083 0.215494990110976 no 697 0.221553382651692 1046 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2005 4024620 188 µM 0.765616111759172 0.21587870183279 no 698 0.221952377435618 1089 236743 SGTC_2598 perillyl alcohol 100 µM 0.765562753237618 0.215893973153254 no 699 0.22196825697694 1084 10819 An apoptosis inducer. SGTC_51 1013-0126 23.419 µM 0.765053028014107 0.216039889128152 no 700 0.222119984330206 1061 1627850 SGTC_2968 9090663 33.37 µM 0.764842564372878 0.216100153948645 no 701 0.222182649250933 1036 25236811 SGTC_1792 st045773 43.6 µM 0.764842197394129 0.216100259038997 no 702 0.222182758526571 1052 2919270 SGTC_1815 st051655 58.2 µM 0.764170263108033 0.216292728020903 no 703 0.222382892521753 1068 5984156 SGTC_321 4534-3890 65.3 µM 0.762564834317269 0.216752988939214 no 704 0.222861481704813 1120 699746 SGTC_2457 5731572 11.68 µM 0.761951005184643 0.216929117381042 no 705 0.223044623281329 1137 2865357 SGTC_876 0720-0963 56.8 µM 0.761151520665627 0.217158640658387 no 706 0.22328328531386 1111 765861 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.760995731623393 0.217203382318767 no 707 0.22332980835661 1063 688662 SGTC_1355 1499-0035 1.68 µM 0.759287601633876 0.217694295952211 no 708 0.223840266282382 1089 1548538 SGTC_1440 4100-1550 40 µM 0.75804270086225 0.218052481241386 no 709 0.224212710076346 1128 742806 SGTC_2353 9059630 146.67 µM 0.75640484688901 0.218524244917675 no 710 0.224703251441591 1115 4779114 SGTC_611 3453-1652 23.7 µM 0.756385559081642 0.218529804032176 no 711 0.224709031812021 1124 1560575 SGTC_389 tpck 16.7 µM 0.755362065559988 0.218824911200016 no 712 0.225015883924585 1080 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1961 st076550 68.7 µM 0.755008443596624 0.218926925428525 no 713 0.225121957983865 1052 1579337 SGTC_1647 st011722 22.4 µM 0.753185783566911 0.219453167134252 no 714 0.225669140517658 1082 2854783 SGTC_23 0213-0011 39.996 µM 0.752929306693316 0.219527275883207 no 715 0.22574619803578 1099 627608 SGTC_1012 4112-3522 18 µM 0.748947526056278 0.220679650158544 no 716 0.226944416740947 1127 3112398 SGTC_686 1319-0111 510 µM 0.745737009849215 0.221611329330279 no 717 0.227913148799042 1143 4562600 SGTC_2979 9012552 45.46 µM 0.743317710565777 0.222314883184335 no 718 0.22864467576813 1117 17100905 SGTC_1919 st067113 52.3 µM 0.743235881900111 0.222338701949427 no 719 0.228669441449696 1080 1268243 SGTC_2034 5197015 53.07 µM 0.743131223894411 0.22236916802191 no 720 0.228701118692032 1105 780676 SGTC_667 1498-1044 59 µM 0.741032704608221 0.222980551906337 no 721 0.229336805395088 1140 6739982 SGTC_105 0111-0055 734.78 µM 0.740887957333625 0.223022757932719 no 722 0.229380688950077 1041 5179370 SGTC_2818 7996756 12.99 µM 0.740222452005323 0.223216867345507 no 723 0.229582513165356 1125 2241621 SGTC_773 4358-1457 44.6 µM 0.739135427192199 0.223534129014488 no 724 0.229912383183244 1174 1186886 SGTC_317 4495-0002 170 µM 0.738244793743331 0.223794262480879 no 725 0.230182853636438 1083 15991618 SGTC_364 0083-0097 67.7 µM 0.73709773386138 0.224129545572393 no 726 0.230531458581442 1136 5207356 SGTC_3212 9128307 49.47 µM 0.736685777115578 0.224250029219832 no 727 0.230656729042934 1050 27243542 SGTC_396 dithiazanine 1.25 µM 0.73649118170959 0.224306954689975 no 728 0.230715916090929 1101 10578 An antihelmenthic. SGTC_2184 6075246 200 µM 0.736362501748427 0.22434460225935 no 729 0.230755059326315 1117 2267320 SGTC_2271 7849410 118.62 µM 0.736094383099732 0.224423056572995 no 730 0.230836630416093 1137 972430 SGTC_3259 9138485 49.47 µM 0.735765254207554 0.224519384405662 no 731 0.230936784972741 1246 17646153 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.735396942997818 0.224627207737414 no 732 0.231048891543925 1129 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2684 capsaicin 100 µM 0.735243725396045 0.22467207093369 no 733 0.231095536864554 1136 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2911 7942208 15.64 µM 0.733822476041409 0.225088464923906 no 734 0.231528470124045 1117 1243384 SGTC_193 1273-0060 1.558 µM 0.733549709650354 0.225168429304131 no 735 0.231611610424061 1016 2847393 YHR072W ERG7 SGTC_312 4092-0653 6.84 µM 0.732213939612021 0.225560256844148 no 736 0.232018998714101 1161 1148278 SGTC_113 0099-0221 2.5 µM 0.731977146152093 0.225629756797194 no 737 0.232091258503255 1121 89219 SGTC_1056 3448-1962 115 µM 0.731702412620085 0.225710407515916 no 738 0.232175111765009 1103 715507 SGTC_1100 amiodarone 5.07 µM 0.730878696182157 0.225952315270368 no 739 0.232426624810296 1170 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2877 9040724 71.43 µM 0.72964215894548 0.226315734631576 no 740 0.232804472619017 1131 6463895 SGTC_1575 cyproterone acetate 48 µM 0.729151945679662 0.226459900076447 no 741 0.232954361161072 1119 9880 An androgen receptor antagonist and liver toxin. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.728034382601906 0.226788754855273 no 742 0.233296269680175 1148 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_420 mitomycin C 81.9 mM 0.727934865976213 0.226818051735704 no 743 0.233326729407106 1143 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_416 estradiol valerate 100 µM 0.725986008571963 0.227392209554184 no 744 0.233923673932496 1166 13791 A steroid. SGTC_1088 bifonazole 369 nM 0.724930968242119 0.227703378945965 no 745 0.234247190623651 1099 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_237 nikkomycin 200 µM 0.724465584696159 0.227840713461647 no 746 0.234389974132956 1167 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.723430431985529 0.228146353726179 no 747 0.23470774015349 1106 140250 A respiratory chain inhibitor. SGTC_2894 9048625 32.47 µM 0.722797135537359 0.228333455099052 no 748 0.234902263720283 1193 4092861 SGTC_1790 st045711 43.5 µM 0.720923798411311 0.228887419149198 no 749 0.235478199873057 1169 585119 SGTC_929 2805-0021 398 µM 0.720787107375211 0.228927869526233 no 750 0.23552025445491 1140 3098024 SGTC_3112 9123419 49.47 µM 0.720743529316989 0.228940766232586 no 751 0.235533662620806 1218 17015854 SGTC_2290 7904846 200 µM 0.720483576466246 0.229017706435705 no 752 0.235613654073722 1184 2962154 SGTC_2285 7945142 200 µM 0.720198627137369 0.229102061698693 no 753 0.23570135453725 1163 2970608 SGTC_192 3455-0609 60.9 µM 0.719185974323624 0.229401984380449 no 754 0.236013170034237 1204 3769639 SGTC_1728 st035614 33.7865 µM 0.718259177264917 0.229676671480118 no 755 0.236298747977488 1140 15945546 SGTC_2134 5324836 1.464 µM 0.716347975801947 0.230243700767168 no 756 0.236888254947753 1110 699272 SGTC_2446 5162541 200 µM 0.71346181600085 0.231101469891333 no 757 0.237780016608985 1115 1549321 SGTC_1481 3346-2004 36 µM 0.712950422635812 0.231253642207208 no 758 0.237938218034445 1189 2770522 SGTC_896 0964-0007 44.5 µM 0.712540577663484 0.231375637704212 no 759 0.238065046734977 1168 6756758 SGTC_2526 patulin 37.61 µM 0.712518207155947 0.231382297599216 no 760 0.238071970473431 1200 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1620 st003704 16.5 µM 0.711367610276856 0.231724984433454 no 761 0.238428232396385 1156 2834414 SGTC_1354 1498-1681 81 µM 0.711112395901002 0.231801034245198 no 762 0.238507294540378 1202 5754243 SGTC_756 0508-1999 28.3 µM 0.708105452260028 0.232698101680251 no 763 0.239439887007821 1164 6753853 SGTC_2106 5357045 167.29 µM 0.70734070434115 0.23292655782076 no 764 0.239677387985158 1179 668842 SGTC_1062 mesoridazine 14.2 µM 0.704308865834836 0.233833495732546 no 765 0.240620223126016 1183 4078 A neuroleptic. SGTC_1743 st037606 46.3785 µM 0.703511572362048 0.234072321025551 no 766 0.240868498743029 1191 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1310 1188-0297 994 nM 0.700997419337433 0.234826306977791 no 767 0.241652312863587 1154 1588352 SGTC_922 1866-0035 480 µM 0.699787045286839 0.235189772206596 no 768 0.242030153125849 1186 3156169 SGTC_2301 7769476 200 µM 0.699526942611998 0.235267919403345 no 769 0.242111390707399 1163 977820 SGTC_75 0159-0059 199.013 µM 0.699265928700559 0.235346354788336 no 770 0.242192927754667 1209 5377270 SGTC_473 2-arachidonoylglycerol 10 µM 0.698523391100927 0.235569568261902 no 771 0.2424249673649 1146 5282280 An endocannabinoid. SGTC_888 0916-0002 6.97 µM 0.697675477357755 0.235824601518228 no 772 0.242690083759394 1220 2802138 YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM 0.697574266722046 0.235855053551845 no 773 0.242721739676415 1184 3124987 SGTC_1264 0783-0040 158 µM 0.696232123963338 0.236259079419444 no 774 0.243141736473728 1137 2855798 SGTC_2516 gossypol 71.55 µM 0.69525253389779 0.236554206318379 no 775 0.243448527535618 1221 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2805 7950783 58.44 µM 0.691969296179631 0.237544844576237 no 776 0.24447830551779 1195 1178958 YDL195W SEC31 SGTC_531 3788-1495 174 µM 0.691807848001896 0.237593616356506 no 777 0.244529003736619 1169 2896655 SGTC_995 3931-2021 34.6 µM 0.690205091431565 0.238078090028837 no 778 0.245032610998771 1180 730143 SGTC_260 nsc-65238 3.989 µM 0.687873567241908 0.23878381774239 no 779 0.245766201696449 1165 3246252 SGTC_2415 st077333 57.7 µM 0.687625181638027 0.238859068831318 no 780 0.245844423173888 1249 2766255 SGTC_830 4076-0286 57.8 µM 0.687552940581842 0.238880957470408 no 781 0.24586717580149 1252 6866659 SGTC_1168 k815-0004 80.5 µM 0.686686304513871 0.239143628886938 no 782 0.246140214596394 1202 642433 SGTC_2855 9016525 58.44 µM 0.685641851597421 0.239460405008041 no 783 0.24646949160703 1236 43811474 SGTC_1021 4476-0760 85.3 µM 0.682757652230426 0.240336353654855 no 784 0.247379996485203 1195 746768 SGTC_1449 4112-4002 201 µM 0.680934968005008 0.240890812668498 no 785 0.247956320333943 1194 2059539 SGTC_2874 9043904 71.43 µM 0.680531092094544 0.241013765489443 no 786 0.248084120828603 1160 4463428 SGTC_2842 9000675 19.48 µM 0.680289241943316 0.241087408790214 no 787 0.248160667511783 1181 2989072 SGTC_1192 1488-0095 21.4 µM 0.679952089248952 0.241190092100286 no 788 0.248267398904637 1207 915875 SGTC_1452 4194-0072 190 µM 0.677651807809476 0.241891300355589 no 789 0.248996244615476 1259 1343545 SGTC_1158 4092-0494 91.8 µM 0.677171421029263 0.242037878951506 no 790 0.249148599076353 1288 1148199 SGTC_1817 st052116 64.4 µM 0.677093753123955 0.242061581987566 no 791 0.249173236074661 1230 4361398 SGTC_109 0132-0036 33.701 µM 0.677050041317562 0.242074922704211 no 792 0.249187102445221 1110 67274 A color developer. SGTC_1742 st038235 28.8875 µM 0.676658216273997 0.242194524374793 no 793 0.249311416508288 1202 564103 YBR002C RER2 SGTC_127 0180-0333 59.125 µM 0.676615652590667 0.242207518550078 no 794 0.249324922644034 1206 771601 SGTC_1856 st057054 55.7 µM 0.675939224229984 0.242414074625213 no 795 0.249539616355503 1286 1266018 SGTC_1464 k208-0027 110 µM 0.675427002499044 0.242570551572971 no 796 0.249702257340491 1246 X1464 SGTC_137 0438-0332 85.389 µM 0.67493527157397 0.242720820296199 no 797 0.249858445017833 1257 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2130 NSC 7 2.4545 µM 0.674735358942633 0.242781926274083 no 798 0.249921957759525 1220 21448 SGTC_1529 apigenin 74 µM 0.674548331595637 0.242839101229557 no 799 0.249981384571411 1289 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2119 5528445 120.635 µM 0.67373119328487 0.243088988889813 no 800 0.25024111326851 1237 791935 SGTC_2008 4012253 172 µM 0.673484547468075 0.243164442534695 no 801 0.250319538134973 1245 603940 SGTC_2728 chlorpromazine 9.18 µM 0.673411318381168 0.243186847142365 no 802 0.250342824968395 1231 2726 A thorazine and dopamine antagonist. SGTC_1057 3448-5381 134 µM 0.673273246148272 0.243229093695568 no 803 0.250386735031724 1249 5497911 SGTC_3222 9128301 49.47 µM 0.672652800527878 0.243418983063136 no 804 0.250584101018306 1253 4911358 SGTC_2139 5578692 56.4705 µM 0.672242066543221 0.243544733563677 no 805 0.250714802303426 1187 650991 YMR113W FOL3 SGTC_1708 st033234 31.827 µM 0.672145261778928 0.24357437646221 no 806 0.250745612186468 1286 674664 SGTC_1434 4073-0095 163 µM 0.671871223376463 0.243658301208296 no 807 0.250832840779384 1230 24133745 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.670667518135161 0.24402712291412 no 808 0.25121617986145 1070 4000243 SGTC_826 1683-5028 118 µM 0.669276812272711 0.244453617284138 no 809 0.2516594577154 1257 722377 SGTC_2824 7998404 51.95 µM 0.66823312655922 0.244773952943955 no 810 0.251992396458882 1213 837851 SGTC_1788 fluconazole 20 µM 0.667027595526703 0.245144244425747 no 811 0.252377253415298 1224 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2622 2-methoxyxanthone 59.94 µM 0.665976562826798 0.245467325777133 no 812 0.252713040544104 1269 71034 A hepatoprotective. SGTC_3217 9129673 49.47 µM 0.665059884783327 0.245749293963706 no 813 0.253006095603432 1232 17248312 SGTC_2356 9061756 188.97 µM 0.663454902383154 0.246243401571493 no 814 0.253519626673622 1217 20104043 SGTC_685 1278-0033 54.9 µM 0.662674920863029 0.246483717768196 no 815 0.253769387593881 1305 3590572 SGTC_1466 k213-0079 57.5 µM 0.662394548016958 0.246570132735189 no 816 0.25385919843007 1221 3657981 SGTC_1472 k841-0093 193 µM 0.661442092179521 0.246863814574744 no 817 0.254164419781369 1304 X1472 SGTC_2442 5158906 48.48 µM 0.661194625950806 0.246940149360245 no 818 0.25424375360795 1273 1893835 SGTC_1364 1653-0028 37.6 µM 0.659800285699103 0.247370491168396 no 819 0.254690999984659 1239 5718652 SGTC_355 1311-2252 105 µM 0.658455302226665 0.247785979284683 no 820 0.25512280481459 1221 5338538 SGTC_149 3970-0822 46.1 µM 0.65839167859537 0.247805642924439 no 821 0.255143240561827 1305 3114250 YBL034C STU1 SGTC_1641 st009299 47.1 µM 0.655926638895795 0.248568133744684 no 822 0.255935663636706 1216 4046054 SGTC_2094 5332512 191.667 µM 0.655884756581127 0.248581099652795 no 823 0.255949138405764 1303 755774 SGTC_2020 4017018 200 µM 0.655582997781869 0.248674528654736 no 824 0.256046234002457 1271 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_359 0081-0058 15.9 µM 0.654542822176056 0.248996725747564 no 825 0.256381073921049 1371 3494159 SGTC_2153 5569715 200 µM 0.65447138868071 0.249018860606529 no 826 0.256404077241501 1274 2054701 SGTC_3028 9087778 49.47 µM 0.653276693591466 0.249389211918988 no 827 0.256788957426585 1215 17217395 SGTC_495 decylubiquinone 155 µM 0.653216941061943 0.249407742679369 no 828 0.256808215055501 1211 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2761 levamisole 97.89 µM 0.653117399125079 0.249438614759506 no 829 0.256840298072411 1294 26879 An alkaline phosphatase inhibitor. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.65229535789668 0.249693641433801 no 830 0.257105327056086 1288 676296 Flavone; oxidizing agent. SGTC_3193 9111931 49.47 µM 0.652108338990845 0.249751680735974 no 831 0.257165642461636 1315 17087244 SGTC_1238 0333-0287 48.8 µM 0.650317315994219 0.25030786803042 no 832 0.257743637080414 1258 7226 SGTC_804 1595-0054 20.9 µM 0.649470827529697 0.250570966327316 no 833 0.258017048275614 1267 761523 Stimulates phospholipase C. SGTC_379 3970-0972 5.9 µM 0.649340154175268 0.250611594150558 no 834 0.258059268461798 1275 2898042 YBL034C STU1 SGTC_3138 9097216 49.47 µM 0.64922340902092 0.250647894490161 no 835 0.258096991516635 1267 25237486 SGTC_2038 4100038 30.985 µM 0.648941394912937 0.250735594482041 no 836 0.258188128581497 1263 3596803 SGTC_2247 cerulenin 830 nM 0.64764763475171 0.251138132724257 no 837 0.258606440197853 1322 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1981 st071826 47 µM 0.64603601390145 0.251640047297278 no 838 0.25912801615851 1230 11838600 SGTC_1637 st007924 17.4 µM 0.643774675034092 0.252345198879816 no 839 0.259860779089558 1257 683336 SGTC_2721 ifenprodil 61.44 µM 0.643234644278753 0.252513750209793 no 840 0.260035928332702 1287 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3286 9117135 37.221 µM 0.64295579422242 0.252600806522133 no 841 0.26012639214795 1232 3438150 SGTC_1925 st057770 10.1 µM 0.640748204211185 0.253290568433229 no 842 0.260843144982713 1210 5989122 SGTC_2709 st078560 56 µM 0.640475251921188 0.253375921161845 no 843 0.260931836725179 1306 17250903 SGTC_2342 7990637 118.86 µM 0.640415946011046 0.253394468237918 no 844 0.260951109339675 1314 2033102 YER133W GLC7 SGTC_3007 9078383 71.4286 µM 0.639865898146285 0.253566521843139 no 845 0.261129893015593 1263 6496995 SGTC_2283 7944793 200 µM 0.63879707226556 0.25390102333278 no 846 0.261477476570509 1246 2970533 SGTC_2132 5317594 122.667 µM 0.638386287321982 0.25402964484027 no 847 0.261611127530014 1290 794577 SGTC_1727 st034309 9.9045 µM 0.638338725692727 0.254044539143189 no 848 0.261626604211176 1348 870305 SGTC_1659 st012954 42.1 µM 0.63669033563903 0.254561028576707 no 849 0.262163284942671 1282 24207262 SGTC_644 1498-1197 63.3 µM 0.63651516565511 0.254615946837094 no 850 0.262220349703291 1328 6741615 SGTC_3059 1327-0034 3 µM 0.635958421799837 0.254790535083772 no 851 0.262401761233782 1241 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_233 rapamycin 362 pM 0.635631116077414 0.25489320350727 no 852 0.262508441760334 1304 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_639 0833-0042 114 µM 0.634605181267148 0.255215156361401 no 853 0.262842974046372 1266 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2689 tacrolimus 100 µM 0.633770277428948 0.255477317836287 no 854 0.263115376604633 1302 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2225 6654152 15.4 µM 0.633270774856002 0.255634229887254 no 855 0.263278417340221 1261 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1717 st033143 58.0435 µM 0.632771404813644 0.255791150601903 no 856 0.263441466377744 1334 674616 SGTC_2409 alverine citrate 63.97 µM 0.627482000039513 0.257456361035333 no 857 0.265171665763652 1424 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2915 7971052 15.16 µM 0.625922582025145 0.257948369769313 no 858 0.265682860950386 1171 5741558 SGTC_3296 9122258 64.045 µM 0.62496684670452 0.258250152737274 no 859 0.265996408778972 1317 4730474 SGTC_2580 diallyl disulphide 81.36 µM 0.624041048895688 0.258542657033697 no 860 0.266300313646422 1320 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2787 5284540 71.43 µM 0.624007211843177 0.258553351043963 no 861 0.266311424415657 1330 736958 SGTC_1368 1852-0141 284 µM 0.623969746757154 0.25856519194105 no 862 0.266323726763375 1289 2838987 SGTC_1118 chelidonine 707.474 nM 0.623485614531017 0.258718227919518 no 863 0.266482726320197 1323 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_182 3448-4371 550.524 µM 0.62261717795966 0.258992861349494 no 864 0.266768060050008 1348 3491403 SGTC_2718 lomofungin 53.02 µM 0.621848311660006 0.259236132563885 no 865 0.267020807747775 1352 5351222 A RNA synthesis inhibitor. SGTC_2596 sinensetin 100 µM 0.621790879889201 0.259254308858498 no 866 0.267039692017964 1298 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2549 cedrol 20.94 µM 0.621499135574956 0.259346651730806 no 867 0.267135631537618 1312 6708665 A sedative which affects the nervous system. SGTC_419 nsc-638432 893 µM 0.621385639567247 0.259382580063295 no 868 0.267172959167796 1311 368090 SGTC_1669 st015249 58.4 µM 0.621162096808631 0.25945335234956 no 869 0.26724648770303 1368 722793 SGTC_503 tyrphostin 8 294 µM 0.618907881262278 0.260167580358573 no 870 0.267988523110544 1285 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2331 7980721 200 µM 0.618586138879568 0.260269604132518 no 871 0.268094517769383 1303 2981221 SGTC_2732 terfenadine 20 µM 0.618328460003646 0.260351328379151 no 872 0.268179422591744 1313 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.618183755605311 0.260397227955879 no 873 0.26822710841695 1421 6728940 SGTC_399 oxolinic acid 75 µM 0.617840386560122 0.260506159731912 no 874 0.268340279174404 1283 4628 A DNA gyrase inhibitor. SGTC_129 0088-0017 176.636 µM 0.616683076154699 0.260873482280683 no 875 0.268721893082493 1246 182446 SGTC_3303 9125618 40.5795 µM 0.616150756758231 0.261042526287083 no 876 0.268897512671647 1376 22695467 SGTC_1469 k284-2957 126 µM 0.616083496000059 0.261063889703348 no 877 0.268919707033554 1332 23884841 SGTC_2568 diosmetin 100 µM 0.614455139453045 0.261581363754786 no 878 0.269457304331619 1324 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3077 9117319 49.47 µM 0.613478001599229 0.261892140135423 no 879 0.269780162044358 1323 17154678 SGTC_2782 7736369 71.43 µM 0.612590879868843 0.262174450994863 no 880 0.270073445053626 1351 2950836 YOL077C BRX1 SGTC_787 4152-0075 138 µM 0.610175169052925 0.262943998054491 no 881 0.27087288832108 1355 9566539 SGTC_124 0136-0217 7.121 µM 0.606486713097733 0.264121213426774 no 882 0.272095801388712 1444 3976905 SGTC_349 k015-0014 24 µM 0.605535760144748 0.264425156338408 no 883 0.272411535747631 1308 2196908 SGTC_128 0906-2981 13.371 µM 0.605460561703836 0.264449198804064 no 884 0.272436510813287 1359 6740226 SGTC_199 4063-0024 41.6 µM 0.605186639835838 0.264536786583377 no 885 0.272527495939634 1366 306215 SGTC_2279 7948423 32.93 µM 0.604948757145972 0.264612862642555 no 886 0.272606522630768 1425 1247112 SGTC_880 0833-0487 87.2 µM 0.604509029096159 0.264753519138582 no 887 0.272752634040609 1296 76075 SGTC_112 phenothiazine 287.218 µM 0.603998881275115 0.264916748538998 no 888 0.272922192975971 1344 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1432 4049-0298 68.4 µM 0.603630974570638 0.265034497508016 no 889 0.273044507355935 1370 741646 SGTC_2714 st079313 56.9 µM 0.603128450549726 0.265195373856802 no 890 0.273211620545214 1332 2939799 SGTC_314 1671-0008 2.74 µM 0.602705738346293 0.26533073790757 no 891 0.273352231730198 1267 3913060 SGTC_1040 k898-0338 155 µM 0.602590667483618 0.265367592828482 no 892 0.273390515160523 1395 20969351 SGTC_1774 st048371 48.465 µM 0.602458960217932 0.265409779248675 no 893 0.273434336686896 1298 4242727 SGTC_2237 6667747 47.222 µM 0.601275202016172 0.265789094932923 no 894 0.273828351699251 1348 729940 YDL015C TSC13 SGTC_54 0159-0055 9 µM 0.600817741621659 0.265935754108366 no 895 0.273980692990678 1432 3319099 SGTC_2238 6671620 73.2395 µM 0.600768775808439 0.265951454695782 no 896 0.273997001835082 1299 729941 SGTC_3280 9140961 49.47 µM 0.598116750100517 0.266802511370765 no 897 0.274881017259624 1324 4901226 SGTC_2326 6164455 177.58 µM 0.597687693170355 0.266940328463483 no 898 0.275024169336956 1345 2888790 SGTC_491 tetrandrine 80.3 µM 0.597499433311561 0.267000810636739 no 899 0.275086992614636 1385 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2458 5808907 16.39 µM 0.596583104074058 0.267295298172433 no 900 0.275392877254114 1372 2731747 SGTC_3207 9114163 49.47 µM 0.595525437494444 0.267635411975308 no 901 0.275746150388836 1474 849233 SGTC_1418 3966-3099 2.4 µM 0.594143159896638 0.268080239527553 no 902 0.276208182939589 1372 740335 SGTC_3341 9147222 25.867 µM 0.594118583644506 0.268088151720263 no 903 0.276216401099563 1339 1939759 SGTC_1421 4029-0249 71.4 µM 0.593901181060144 0.268158148436218 no 904 0.276289104521852 1440 2894095 SGTC_701 4424-0219 185 µM 0.59371430499084 0.268218323935433 no 905 0.276351606819234 1373 2911779 SGTC_811 0416-0114 265 µM 0.590684145358751 0.26919500541377 no 906 0.277366036495462 1357 6612453 SGTC_5 0352-0601 109.883 µM 0.590423833197895 0.26927899240851 no 907 0.277453268037607 1282 762456 SGTC_975 1335-0046 28.5 µM 0.589568539854771 0.269555036347767 no 908 0.277739974295031 1287 16486740 SGTC_9 0092-0002 10.449 µM 0.588057223787228 0.270043156501936 no 909 0.278246941956689 1354 759368 SGTC_1505 k297-0037 20.6 µM 0.58782283541201 0.270118898123506 no 910 0.278325607417596 1329 4089396 SGTC_1594 piperine 70.1 µM 0.586452218881059 0.270562019766509 no 911 0.278785830860871 1335 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1289 0976-0073 69.1 µM 0.581752354775351 0.272084242499543 no 912 0.280366750478693 1404 3391136 SGTC_2210 7115885 190.385 µM 0.581334354562783 0.272219833054313 no 913 0.28050756549196 1350 2927039 SGTC_477 mead ethanolamide 10 µM 0.581153153501092 0.272278621333213 no 914 0.280568618750123 1288 16061185 SGTC_1855 st056195 39.6 µM 0.58081788042303 0.272387412864445 no 915 0.280681601453145 1396 4028379 SGTC_3159 9100096 49.47 µM 0.579713454755928 0.27274593653713 no 916 0.281053934235703 1304 25236875 SGTC_1213 1315-0166 115 µM 0.578840680483441 0.273029426009337 no 917 0.281348339551265 1322 768401 SGTC_1921 5740136 50 µM 0.57708119814122 0.273601374531616 no 918 0.281942302462395 1454 1774243 SGTC_2218 6965428 192.983 µM 0.576404997892524 0.273821342087608 no 919 0.282170733511786 1378 675684 SGTC_1546 5-methoxyflavanone 78.7 µM 0.576190116471296 0.273891261197237 no 920 0.282243342475047 1420 147795 SGTC_504 lovastatin 124 µM 0.575679441910612 0.274057462250852 no 921 0.282415936738905 1339 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2593 nobiletin 86.24 µM 0.571741733157469 0.275340676212997 no 922 0.283748478388994 1325 72344 An anti-infammatory. SGTC_2846 9008642 19.48 µM 0.571309684144097 0.275481651431094 no 923 0.283894869177927 1377 2992898 SGTC_2869 9037858 32.47 µM 0.570064929620678 0.275888006381635 no 924 0.28431683024078 1322 27187042 SGTC_2449 5812982 45.77 µM 0.567871800047968 0.276604677733682 no 925 0.285061010777686 1368 776185 SGTC_2652 actinonin 100 µM 0.567797707731314 0.276628905562229 no 926 0.285086168254742 1364 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2722 naftopidil 47.16 µM 0.567704199123232 0.276659483908518 no 927 0.285117919895172 1413 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2515 chrysin 20.77 µM 0.566829388507874 0.276945636839663 no 928 0.285415050877888 1440 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1077 5-fluorocytosine 377 nM 0.565617551891871 0.27734227114244 no 929 0.285826896785354 1386 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3038 9091290 49.47 µM 0.563126114269873 0.278158590572721 no 930 0.28667450514463 1428 25236843 SGTC_1889 st059080 5.18 µM 0.562513213308925 0.278359586990953 no 931 0.286883201808255 1433 176925 Isolated from Daphnopsis sellowiana. SGTC_2620 irigenin 100 µM 0.562269858477493 0.278439413068835 no 932 0.28696608563381 1479 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_987 1497-1013 404 µM 0.561977881975991 0.278535202909502 no 933 0.287065544401813 1383 1676435 SGTC_807 1315-0151 48 µM 0.561596664099882 0.278660294663602 no 934 0.287195426883886 1436 4011080 SGTC_990 3985-0011 41.3 µM 0.561029655892517 0.278846401716117 no 935 0.287388660326366 1396 5399565 YGL099W LSG1 SGTC_1261 0712-0010 12.7 µM 0.560573493350053 0.278996170187426 no 936 0.287544162771616 1454 2840123 SGTC_654 1124-0271 80.9 µM 0.560335350916414 0.279074373271411 no 937 0.287625359571887 1364 5403748 SGTC_532 1548-0774 215 µM 0.559193338765167 0.279449544247039 no 938 0.288014889382933 1506 5932993 SGTC_2490 carminic acid 95.39 µM 0.5584344858744 0.279698976088235 no 939 0.288273864735878 1366 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_270 tamoxifen 5.46 µM 0.55797004387446 0.279851689552754 no 940 0.288432420009378 1504 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.557416618804839 0.280033714386889 no 941 0.288621406758003 1385 115019 SGTC_374 0880-0231 82.3 µM 0.557167819987877 0.280115564510295 no 942 0.288706386998268 1361 6833587 SGTC_282 k297-0036 65.7 µM 0.556937503613873 0.280191344590664 no 943 0.288785064837794 1418 5061378 SGTC_2379 9035213 200 µM 0.555089898645304 0.280799613877483 no 944 0.2894165858523 1522 646551 SGTC_1843 st055809 45.5 µM 0.554359842578392 0.28104013911525 no 945 0.289666301521037 1399 16413835 SGTC_1171 0368-0077 21.4 µM 0.554037209960917 0.281146465791145 no 946 0.289776690216145 1381 3239779 SGTC_2893 9048488 25.97 µM 0.552475676246298 0.281661358619991 no 947 0.29031124745752 1335 6467338 SGTC_1716 st033144 30.6155 µM 0.5514280423805 0.282007055171471 no 948 0.290670140871222 1458 674617 SGTC_1411 3909-8223 150 µM 0.55044811790071 0.282330593939767 no 949 0.29100602644983 1453 X1411 SGTC_372 0155-0182 15.9 µM 0.5477264134647 0.28323014669499 no 950 0.291939886354948 1412 771486 SGTC_2757 clomiphene 4.22 µM 0.546956843683496 0.283484746931613 no 951 0.292204190803606 1521 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1069 diphenylcyclopropenone 8.49 µM 0.546392336520648 0.283671575092715 no 952 0.292398138395191 1460 65057 A dermal irritant. YDR527W RBA50 SGTC_675 1309-0189 238 µM 0.545737841938156 0.283888259109048 no 953 0.292623077837667 1382 4246530 SGTC_2792 7535235 81.82 µM 0.545209774030948 0.284063144675166 no 954 0.29280462500746 1380 1281891 SGTC_1929 genistein trimethyl ether 50.5 µM 0.544936748815911 0.284153585391315 no 955 0.292898510247721 1519 136420 SGTC_89 0302-0250 142.109 µM 0.544508975239851 0.284295314815901 no 956 0.293045636928685 1473 4203518 YLR208W SEC13 SGTC_384 k007-0144 5.16 µM 0.544071744598617 0.284440212452978 no 957 0.293196051652172 1443 6824886 SGTC_890 0929-0006 47.2 µM 0.543870160886818 0.284507028900843 no 958 0.293265411906911 1372 1378169 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.543697569698515 0.284564241513694 no 959 0.293324802553224 1427 7104 SGTC_431 k089-0097 107 µM 0.542036187816603 0.28511525726921 no 960 0.293896788347384 1363 5499420 SGTC_565 1418-0001 44.5 µM 0.539403881321399 0.285989330796725 no 961 0.294804101742534 1464 2862145 SGTC_1174 0739-0097 51.1 µM 0.539261389773252 0.286036682303325 no 962 0.294853253092232 1434 728447 SGTC_810 3825-7150 143 µM 0.537894859203256 0.286490984507113 no 963 0.29532481886519 1520 22330411 YGL099W LSG1 SGTC_2074 5212007 75.395 µM 0.537717194214337 0.286550074257332 no 964 0.295386153426917 1413 758611 SGTC_972 1319-0219 195 µM 0.537582732021562 0.28659479899598 no 965 0.29543257715872 1377 23903702 SGTC_2556 citropten 84.59 µM 0.537211580732433 0.28671826830809 no 966 0.295560736376235 1396 2775 A potential DNA crosslinker. SGTC_2138 5575593 77.673 µM 0.536809557677405 0.286852036044635 no 967 0.295699584503206 1409 762213 SGTC_1336 1486-0901 104 µM 0.536653028416309 0.286904127038354 no 968 0.295753653675215 1462 5006114 SGTC_2426 5582046 32.21 µM 0.536539391286799 0.286941946871307 no 969 0.295792909664167 1461 2251934 SGTC_759 3486-0358 89.3 µM 0.535963359861575 0.287133693528482 no 970 0.295991936745971 1524 875103 SGTC_1474 0330-0125 5.35 µM 0.535068866295667 0.287431568564384 no 971 0.296301118838428 1435 X1474 SGTC_1426 4048-4480 71.7 µM 0.534974410248097 0.287463031874362 no 972 0.296333776255892 1484 14224343 SGTC_947 3447-0010 211 µM 0.534475166819906 0.287629356912184 no 973 0.296506413056381 1421 748350 SGTC_3061 glucosamine 200 µM 0.534380631233108 0.287660856959863 no 974 0.296539108352578 1422 91431 and experimental redox chemotherapeutic SGTC_1880 MG-132 525 µM 0.533842909155829 0.287840061453932 no 975 0.296725111874455 1456 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2101 5377231 179.231 µM 0.533522497952208 0.28794686868334 no 976 0.296835970753433 1507 2844213 SGTC_733 4069-0007 56.1 µM 0.533311261436221 0.288017293392325 no 977 0.296909066714733 1458 5717425 YNL287W SEC21 SGTC_3211 9128781 49.47 µM 0.532239301580293 0.288374802222122 no 978 0.297280132948859 1431 17194361 SGTC_1226 3909-7979 35.4 µM 0.530290274210279 0.289025356893737 no 979 0.29795534443748 1501 6615510 SGTC_857 0438-0306 1.35 µM 0.529133922534924 0.289411654905181 no 980 0.298356275377686 1458 4686136 SGTC_513 4245-1575 41.7 µM 0.527815159652133 0.289852504824801 no 981 0.298813817115338 1480 719745 SGTC_794 k038-0031 316 µM 0.527045336245982 0.290109995006582 no 982 0.299081052874426 1430 6624242 SGTC_554 4483-2211 187 µM 0.525256775191987 0.290708645581226 no 983 0.299702350725798 1441 747107 SGTC_1753 st043925 64 µM 0.523074999355642 0.291439690606931 no 984 0.300461031280503 1483 670181 SGTC_777 1315-0167 517 µM 0.521992980002856 0.291802559375571 no 985 0.300837609165429 1399 4221767 SGTC_1134 3477-0009 42.5 µM 0.521121237377691 0.292095062228809 no 986 0.301141158685538 1637 3973534 SGTC_106 0092-0003 11.579 µM 0.520100948279347 0.292437581307823 no 987 0.301496608750828 1523 1072148 SGTC_439 amiodarone 34.4 µM 0.519418347705337 0.292666839887281 no 988 0.301734519662806 1517 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2113 5491891 107.031 µM 0.518863012286153 0.292853416692064 no 989 0.301928136322771 1435 789979 SGTC_2163 5671233 125 µM 0.518353943868813 0.293024497598208 no 990 0.302105671097707 1574 701023 SGTC_2040 5100729 123 µM 0.516082008377549 0.293788583913454 no 991 0.302898566632167 1492 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_459 nigericin 15.3 µM 0.515608084344968 0.293948087873938 no 992 0.303064081403572 1491 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1384 3089-0840 101 µM 0.514550153321931 0.294304289724671 no 993 0.303433702566776 1542 1069836 SGTC_1179 1021-1431 9.29 µM 0.513449508272289 0.2946750846859 no 994 0.303818460815746 1473 2840958 SGTC_2486 5283202 22.39 µM 0.513348668841269 0.294709067130328 no 995 0.303853722664735 1414 1377751 SGTC_2142 5622915 118.518 µM 0.512608915995975 0.294958415824831 no 996 0.304112457559932 1444 5322196 SGTC_872 0588-0139 234 µM 0.511245287404034 0.295418309052616 no 997 0.304589655435775 1454 2047100 SGTC_2108 5365811 200 µM 0.51118984680836 0.295437013755229 no 998 0.304609063756268 1534 780283 SGTC_3242 9133940 49.47 µM 0.511159217254154 0.29544734787317 no 999 0.304619786607917 1489 17248444 SGTC_2411 st077133 39.94 µM 0.5109537942171 0.295516659932946 no 1000 0.304691705827412 1619 1403142 YNL221C POP1 SGTC_2885 9057732 51.95 µM 0.510848240275055 0.295552277936723 no 1001 0.304728663514388 1453 6471414 SGTC_326 k292-0812 17.5 µM 0.508200755440973 0.296446287133071 no 1002 0.305656280570598 1499 3579357 SGTC_2594 a-mangostin 100 µM 0.506673517493466 0.296962571675353 no 1003 0.306191957529503 1568 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_259 usnic acid 108.925 µM 0.506642748164625 0.296972977508238 no 1004 0.306202754100807 1511 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3348 9149464 3.537 µM 0.506581433286905 0.296993713991569 no 1005 0.306224269223703 1449 1951442 SGTC_480 am 92016 50 µM 0.505532404350818 0.297348594568432 no 1006 0.306592472373229 1407 2129 K+ channel blocker. SGTC_2734 clemastine 41.6 µM 0.505500227766877 0.297359482786986 no 1007 0.306603769258806 1478 26987 Clemastine is a selective histamine H1 antagonist. SGTC_775 4577-0580 57.3 µM 0.504663920561851 0.297642544238279 no 1008 0.306897453009355 1532 2006902 SGTC_79 0052-0007 94.094 µM 0.503553717447608 0.298018499957841 no 1009 0.307287511553544 1554 2801472 SGTC_3281 9140613 49.47 µM 0.50174820989137 0.298630373120232 no 1010 0.307922323873116 1391 16013766 SGTC_849 0386-0493 241 µM 0.498632507076541 0.299687602977886 no 1011 0.309019150050109 1442 726119 SGTC_1816 st051957 91.6 µM 0.497725598635012 0.299995656218826 no 1012 0.309338731367258 1491 674121 SGTC_1956 st077085 54 µM 0.497640735968745 0.30002448919164 no 1013 0.309368643119596 1460 24208685 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.49726107187273 0.300153499362992 no 1014 0.309502479721259 1467 2724 A muscle relaxant with antifungal properties. SGTC_440 fluspirilene 35.1 µM 0.493962193173495 0.301275515375119 no 1015 0.310666440091107 1570 3396 An atypical antipsychotic. SGTC_2895 9054447 58.44 µM 0.493816343940866 0.301325165252561 no 1016 0.310717944715427 1504 2697450 SGTC_32 0928-0142 34.1 µM 0.492999497280007 0.301603303601712 no 1017 0.311006471276938 1477 2244242 SGTC_37 0566-0070 1.56 µM 0.4925597734978 0.301753078458749 no 1018 0.311161838630875 1582 1626686 SGTC_3330 9141424 71.43 µM 0.491668241677106 0.302056846778286 no 1019 0.311476946327224 1571 27261020 SGTC_3204 9114183 49.47 µM 0.491507680564646 0.302111568757721 no 1020 0.311533710577856 1481 17027248 SGTC_1831 st055328 12 µM 0.491076426266863 0.302258569642002 no 1021 0.311686196984332 1578 1103068 SGTC_361 000s-0510 1.45 µM 0.489927968911691 0.302650198707507 no 1022 0.312092435357236 1499 660 SGTC_517 1365-0151 113 µM 0.488507095526184 0.303135037237623 no 1023 0.312595350537227 1515 768657 SGTC_2365 9042475 200 µM 0.488345517326574 0.303190193864964 no 1024 0.312652562932252 1476 6464479 SGTC_1004 4084-0029 199 µM 0.486192919617779 0.303925436230518 no 1025 0.313415195461609 1585 716894 YLR208W SEC13 SGTC_1046 2001-0062 216 µM 0.484764127478754 0.304413893778835 no 1026 0.313921835826119 1486 739778 SGTC_803 4488-1585 147 µM 0.483101010240977 0.304982899108898 no 1027 0.31451200839715 1556 747204 SGTC_1730 st033808 45.1 µM 0.483071873634243 0.304992871878709 no 1028 0.314522352023915 1534 1045166 SGTC_836 0330-0104 1.35 µM 0.482660909514343 0.30513355058101 no 1029 0.314668261645022 1524 46494820 SGTC_2826 7992541 19.48 µM 0.482636097197031 0.3051420451024 no 1030 0.31467707199244 1546 2985066 SGTC_2962 9082311 13.18 µM 0.479066496042397 0.30636519358388 no 1031 0.315945661858707 1456 16459453 SGTC_2377 9073351 62.6 µM 0.476563394824843 0.3072241884409 no 1032 0.316836527333151 1480 7337946 YHR072W ERG7 SGTC_3013 9080133 71.4286 µM 0.472427376844505 0.308645873847303 no 1033 0.31831088359721 1594 17050193 SGTC_398 bronopol 33.3 µM 0.472360898158592 0.308668748273609 no 1034 0.318334604692284 1554 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2154 5570129 200 µM 0.469957130956599 0.309496350596491 no 1035 0.319192822844799 1514 673366 SGTC_2335 9018011 154.17 µM 0.46981915493048 0.309543884283276 no 1036 0.319242113966569 1633 6458208 SGTC_2713 st079149 53.4 µM 0.466749941691485 0.310602071823433 no 1037 0.320339397056284 1569 3103253 SGTC_2023 5144124 124 µM 0.466143891884295 0.310811208328431 no 1038 0.320556253864229 1513 2830192 SGTC_1413 3910-0535 34.4 µM 0.465752113314028 0.3109464363577 no 1039 0.320696472725909 1605 2876951 SGTC_897 1000-0139 31.4 µM 0.465326862059244 0.311093246866065 no 1040 0.320848700533888 1645 6151020 SGTC_1295 1013-0063 9.78 µM 0.46350513818685 0.311722504977498 no 1041 0.32150116635877 1630 6826038 SGTC_2007 4011539 71.82 µM 0.462349065488517 0.31212211996946 no 1042 0.32191550955521 1523 45595301 SGTC_3210 9128157 49.47 µM 0.461349109209293 0.312467949248479 no 1043 0.322274078408694 1496 17590849 SGTC_984 1492-0255 2.91 µM 0.459866333285659 0.312981063096409 no 1044 0.322806083411056 1575 1585198 SGTC_1214 0358-0031 63.7 µM 0.457678621281764 0.31373878145975 no 1045 0.323591674760825 1725 4301366 SGTC_1090 efavirenz 20.7 µM 0.457415331535157 0.313830025456356 no 1046 0.323686273294019 1580 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2248 tofa 1.1 µM 0.457162330115092 0.313917714724905 no 1047 0.32377718602343 1546 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2844 9010103 25.97 µM 0.456018927854344 0.314314144343662 no 1048 0.324188183657715 1536 2480525 SGTC_2931 9014674 55.67 µM 0.455342828085821 0.314548656101344 no 1049 0.32443130959564 1480 2996810 SGTC_2680 butyl paraben 22.24 µM 0.455030050658925 0.314657171309497 no 1050 0.324543809903445 1565 7184 An antifungal and steroid mimetic. SGTC_118 0083-0097 135.343 µM 0.454551196948351 0.314823336149829 no 1051 0.324716075826702 1569 5207356 SGTC_1175 0741-0056 27.6 µM 0.454309603479285 0.314907184630385 no 1052 0.324803002454504 1644 765927 SGTC_728 3030-5151 22.5 µM 0.45399891689106 0.315015026893702 no 1053 0.324914803181878 1565 3125388 SGTC_1280 0880-0253 10.1 µM 0.453265926063484 0.315269517450678 no 1054 0.325178632784562 1527 6836607 SGTC_2817 7995342 71.43 µM 0.45313302299111 0.315315670091604 no 1055 0.325226478743793 1458 18879975 SGTC_1394 3474-0001 65.7 µM 0.453026694829398 0.315352596260412 no 1056 0.325264759639462 1497 5017666 YIL048W NEO1 SGTC_1470 k295-0292 231 µM 0.452954682033413 0.315377606267277 no 1057 0.325290687160942 1609 5045612 SGTC_965 1291-5240 308 µM 0.452686092442513 0.315470894754335 no 1058 0.325387397744424 1642 2834598 SGTC_3041 9091929 49.47 µM 0.452441920983716 0.315555712366118 no 1059 0.325475326338421 1587 25236887 SGTC_2563 tomatine 8.54 µM 0.450753407024241 0.316142515640798 no 1060 0.326083642807155 1777 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3029 9088683 49.47 µM 0.450606220251962 0.316193688917741 no 1061 0.326136691363887 1563 25236615 SGTC_727 3032-0951 202 µM 0.449008743913296 0.31674931907398 no 1062 0.32671267449337 1581 3652836 SGTC_12 0849-0099 9.267 µM 0.448951107751887 0.316769373675804 no 1063 0.326733463413376 1603 6071388 SGTC_2314 7727897 200 µM 0.448424749355729 0.316952545896194 no 1064 0.326923341719181 1511 900724 SGTC_1223 0764-0573 147 µM 0.447043162486956 0.317433550185082 no 1065 0.327421947905299 1538 1609797 SGTC_1516 st013856 110 µM 0.446023816760567 0.317788636756439 no 1066 0.327790021023503 1542 5281404 A mutagen and neurotoxin. SGTC_1337 1486-1011 40.3 µM 0.443258298536119 0.318752841852891 no 1067 0.328789457598701 1542 X1337 SGTC_563 tetrahydrosecaminediol 614 µM 0.441142649496952 0.319491298079778 no 1068 0.329554864512497 1670 334274 A psychoactive constituent of the cannabis plant. SGTC_1333 1482-0047 286 µM 0.439513061619514 0.320060585841853 no 1069 0.330144909918529 1629 3811116 SGTC_1675 st018485 24.5 µM 0.439069278326721 0.320215692649856 no 1070 0.330305669418336 1571 3323024 SGTC_1603 st002045 67.8 µM 0.43714260885806 0.320889447400793 no 1071 0.331003964006794 1619 5887985 SGTC_2656 pseudo-anisatin 100 µM 0.437060796288238 0.320918070270027 no 1072 0.33103362887374 1597 6708809 A neurotoxin. SGTC_2233 sulbentine 40.3845 µM 0.436577287686629 0.321087251865764 no 1073 0.331208968554633 1552 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3356 9151811 4.48 µM 0.436050004712655 0.321271792631347 no 1074 0.33140022477853 1543 1859254 YPR165W RHO1 SGTC_542 3381-0244 89.3 µM 0.433680062453272 0.322101779697721 no 1075 0.332260393320441 1682 1112843 SGTC_2400 5203494 178.7 µM 0.430957850423984 0.323056232373368 no 1076 0.333249509157827 1534 6777674 SGTC_222 nsc-310342 10.666 µM 0.430451674336015 0.323233834879569 no 1077 0.333433556454299 1665 432556 SGTC_2812 7970281 58.44 µM 0.42982407429481 0.323454097481673 no 1078 0.333661809587051 1695 2233435 SGTC_1149 3909-7961 23.3 µM 0.429163193782678 0.323686107095 no 1079 0.333902233126641 1542 735261 SGTC_1973 st070275 50.2 µM 0.428600866943649 0.323883572298931 no 1080 0.334106857260532 1583 17118334 SGTC_1338 1486-1223 76 µM 0.428495392780334 0.323920615850064 no 1081 0.334145243565021 1647 3444526 SGTC_927 2425-1185 123 µM 0.427080386913642 0.324417748171427 no 1082 0.334660388926135 1525 730375 SGTC_2091 4-phenylthiadiazole 200 µM 0.425917368924004 0.324826584370278 no 1083 0.335084029077367 1607 270010 SGTC_2402 5553605 200 µM 0.423810854542267 0.325567625431373 no 1084 0.335851880663514 1664 6758546 SGTC_1358 1509-0022 2.48 µM 0.423777491154208 0.325579367743001 no 1085 0.335864047572022 1585 3258434 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.42121424386549 0.326482024537909 no 1086 0.336799322071629 1544 5355888 SGTC_2453 5731132 22.18 µM 0.417947879579981 0.327633759913734 no 1087 0.337992612424437 1727 1362040 SGTC_1044 1222-0021 1.78 µM 0.416608903035192 0.328106364488063 no 1088 0.338482248105117 1625 4306703 SGTC_1490 4089-0339 670 nM 0.414536752816174 0.328838292257215 no 1089 0.339240528348399 1696 742542 SGTC_46 0329-0187a 2.197 µM 0.412788056779017 0.329456480378376 no 1090 0.339880951246337 1677 46494817 SGTC_2362 9071156 126 µM 0.410952551178007 0.33010585862032 no 1091 0.340553663735782 1659 653133 SGTC_2380 9035439 200 µM 0.409895367619833 0.330480109135115 no 1092 0.340941351833785 1688 6462575 SGTC_370 0180-0345 38.7 µM 0.409577714692439 0.330592593687095 no 1093 0.341057873683913 1583 3989527 SGTC_2754 granisetron 64.02 µM 0.40883400121747 0.330856011018961 no 1094 0.341330742888659 1732 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_357 1325-0123 420 µM 0.408015509407514 0.331146011065654 no 1095 0.341631144247633 1712 1098503 SGTC_1166 k206-0078 225 µM 0.407635977905428 0.331280517363538 no 1096 0.341770473262004 1583 5404595 SGTC_2723 salbutamol 83.58 µM 0.406988288794025 0.331510109222269 no 1097 0.342008294830454 1666 9884233 β2-adrenoceptor agonist SGTC_1649 st011737 51.3 µM 0.406938217639034 0.331527861007731 no 1098 0.342026682807242 1603 1761035 SGTC_1997 st073024 93.8 µM 0.404474130819765 0.332401923477733 no 1099 0.342932048610629 1675 686268 SGTC_2614 arthonioic acid 13.39 µM 0.404040047989065 0.332555996258472 no 1100 0.34309163492521 1536 6710684 SGTC_1485 3909-9022 254 µM 0.402859695045524 0.332975092152661 no 1101 0.343525721630626 1619 714516 SGTC_417 st075190 100 µM 0.402283325916284 0.333179813544283 no 1102 0.343737762248377 1728 222757 SGTC_507 nimesulide 162 µM 0.402016607547937 0.333274566460845 no 1103 0.343835901996873 1720 4495 A COX2 inhibitor. SGTC_3225 9130819 49.47 µM 0.401856055061101 0.333331608595092 no 1104 0.343894982795103 1659 4547121 SGTC_1385 3091-4834 14.1 µM 0.401321628814675 0.333521510801306 no 1105 0.344091670731326 1687 4072814 SGTC_958 1222-0007 33 µM 0.400149291391282 0.333938236796548 no 1106 0.344523280469829 1712 7312461 SGTC_2832 7992762 51.95 µM 0.398398999246713 0.334560787146161 no 1107 0.345168047740279 1462 2985177 SGTC_1534 6-azauridine 81.6 µM 0.397834604998779 0.334761630097224 no 1108 0.345376053545705 1630 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1705 st027868 56.3335 µM 0.396720342002284 0.335158285785808 no 1109 0.345786848914106 1730 292948 SGTC_1081 sertraline 6 µM 0.396560257134128 0.335215287964631 no 1110 0.345845882338748 1728 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1930 st074634 34.3 µM 0.394847187160848 0.335825506265683 no 1111 0.346477834054233 1548 684253 YOR116C RPO31 SGTC_1237 0330-0133 46.1 µM 0.393640685830582 0.336255538118744 no 1112 0.346923169256659 1633 X1237 YHR072W ERG7 SGTC_662 k832-1615 104 µM 0.392974582475959 0.336493048430023 no 1113 0.347169127271318 1681 5878478 SGTC_2229 7354935 190 µM 0.392338780963087 0.336719814983948 no 1114 0.347403956425355 1681 318112 SGTC_2665 lovastatin 100 µM 0.392112025227957 0.336800704619701 no 1115 0.347487721358665 1627 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1344 1488-0097 29.1 µM 0.389702601805472 0.337660673944811 no 1116 0.348378236185025 1666 747966 SGTC_3153 9100258 49.47 µM 0.389308433059974 0.337801441175219 no 1117 0.348523999371287 1594 25236848 SGTC_1522 st012842 45.6 µM 0.388911733212083 0.3379431352338 no 1118 0.348670721141975 1540 3491067 YOR116C RPO31 SGTC_183 3914-0051 30.55 µM 0.386827090676461 0.338688109123842 no 1119 0.349442110034372 1789 1596232 SGTC_442 cape 100 µM 0.386766296139797 0.338709844326695 no 1120 0.349464615440508 1751 5281787 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.386664945371158 0.338746080347759 no 1121 0.349502135452271 1671 364106 SGTC_280 3448-3607 3.04 µM 0.385679782949814 0.339098383973283 no 1122 0.34986691872625 1739 626179 SGTC_1798 st045719 60.953 µM 0.383182256908307 0.339992153571651 no 1123 0.350792316414406 1718 3980186 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.382569661920256 0.340211515670903 no 1124 0.351019434132785 1637 688667 SGTC_3063 1327-0034 4 µM 0.380510552168693 0.340949251533355 no 1125 0.351783232546646 1668 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2892 9047358 58.44 µM 0.379988178257643 0.341136504047021 no 1126 0.351977095271229 1634 6466771 SGTC_2261 9010538 184.68 µM 0.378738823001257 0.341584512221154 no 1127 0.352440910370868 1593 6457250 SGTC_1821 st053465 65.6 µM 0.378580801272445 0.341641193388293 no 1128 0.352499590572356 1624 675086 SGTC_589 1227-0070 34.1 µM 0.37822372111525 0.341769288418055 no 1129 0.352632202577892 1684 2841384 SGTC_2270 7924575 90.91 µM 0.378074371707075 0.341822869796136 no 1130 0.352687673097274 1820 1262135 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.377361354418175 0.342078719528492 no 1131 0.352952541133335 1626 61125 An anti-inflammatory. SGTC_2704 st078022 71.1 µM 0.377266378299004 0.342112804984137 no 1132 0.352987827760999 1794 54697681 SGTC_1558 st069300 45.6 µM 0.376904849665132 0.342242563769549 no 1133 0.3531221586301 1755 24208000 SGTC_2055 5235184 200 µM 0.376206150378259 0.34249339162473 no 1134 0.353381821691254 1680 2836034 SGTC_231 b-estradiol 524 µM 0.375983549810277 0.342573318174505 no 1135 0.3534645628187 1626 450 A steroid. SGTC_1129 3453-1384 223 µM 0.373164903551124 0.343585984796627 no 1136 0.354512857757341 1713 1084452 SGTC_2865 9030313 51.95 µM 0.372436848863267 0.343847738884758 no 1137 0.354783811297373 1603 42562754 SGTC_508 roscovitine 141 µM 0.372406838121174 0.34385853011357 no 1138 0.354794981702027 1722 160355 A CDKinase inhibitor. SGTC_3037 9091026 49.47 µM 0.370484869227019 0.344549894114539 no 1139 0.355510624193236 1715 25236398 YIL048W NEO1 SGTC_1588 farnesol 29.9 µM 0.36985314740937 0.344777248476745 no 1140 0.355745956371453 1635 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_640 3381-0960 37.1 µM 0.369105077345089 0.345046548650281 no 1141 0.35602470229032 1751 1745025 SGTC_1196 1588-0294 184 µM 0.368702915454967 0.345191356669849 no 1142 0.356174587705142 1636 6144269 SGTC_1156 4092-0367 4.88 µM 0.368182494168765 0.345378780463647 no 1143 0.356368581290436 1697 1357585 SGTC_2735 sertaconazole 140 nM 0.367369793665539 0.345671541119273 no 1144 0.356671599970487 1755 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2404 5161160 200 µM 0.365511848039496 0.346341178963275 no 1145 0.357364682137203 1726 2831543 SGTC_2175 5807670 165.306 µM 0.365402399174684 0.346380641360837 no 1146 0.357405525301226 1755 241186 SGTC_397 arbidol 50 µM 0.365360144985405 0.346395876790226 no 1147 0.357421293784733 1762 131410 A RNA synthesis inhibitor. SGTC_1605 st000082 49.1 µM 0.364886450939901 0.346566691822701 no 1148 0.357598084315012 1741 1114022 SGTC_2695 st077686 51.995 µM 0.362672521347461 0.347365452535329 no 1149 0.358424764451107 1632 2876092 SGTC_2217 6934799 96.0675 µM 0.361843644900081 0.347664676485426 no 1150 0.358734437508824 1747 675606 SGTC_100 0086-0128 49.5915 µM 0.36116242788708 0.347910666536554 no 1151 0.358989013695857 1596 93297 SGTC_1784 st039334 36.3 µM 0.360799031567342 0.34804191652213 no 1152 0.359124843402894 1783 3496984 SGTC_3234 9132280 49.47 µM 0.359280835631033 0.34859044903423 no 1153 0.359692504755798 1697 17612295 SGTC_391 gliotoxin 8.33 µM 0.359264728062867 0.348596270486842 no 1154 0.359698529121734 1740 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2790 5423970 71.43 µM 0.359106437516279 0.348653480331048 no 1155 0.359757732971595 1794 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2769 toremifene 3.73 µM 0.358433819910096 0.348896618177889 no 1156 0.360009343010179 1714 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2952 9073731 13.78 µM 0.358419152097593 0.348901920991266 no 1157 0.360014830561667 1626 16457353 SGTC_3338 9144300 39.5675 µM 0.35812697074092 0.349007558650768 no 1158 0.360124148047701 1742 4901274 SGTC_1035 k081-0041 55.2 µM 0.357216861549589 0.349336682008239 no 1159 0.360464731921169 1812 731709 SGTC_3170 9103054 49.47 µM 0.356316529669471 0.349662381098831 no 1160 0.360801765865672 1662 16432970 SGTC_2205 7238770 200 µM 0.355884617304264 0.349818666632534 no 1161 0.36096348811608 1771 279867 SGTC_1838 st055369 84.5 µM 0.354580253171357 0.350290799277614 no 1162 0.361452035912466 1657 676036 SGTC_1504 k297-0033 30 µM 0.353789959133573 0.350576969784035 no 1163 0.361748149456436 1635 4388117 SGTC_1227 3909-8010 46.6 µM 0.352919605611248 0.350892228481374 no 1164 0.362074356118972 1701 15982272 SGTC_3295 9122362 53.5725 µM 0.351156437932924 0.351531196055006 no 1165 0.362735494557846 1680 4730473 SGTC_2937 9044753 11.33 µM 0.350585912440239 0.351738043043934 no 1166 0.362949513391147 1666 6465530 YGL099W LSG1 SGTC_1408 3909-7976 48.8 µM 0.349528578358327 0.352121501044571 no 1167 0.363346259832736 1734 24152374 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.348555597965897 0.35247449982747 no 1168 0.363711483580309 1646 6708514 SGTC_723 4182-0001 115 µM 0.348201929991642 0.352602842624342 no 1169 0.363844269224177 1668 744821 YLR208W SEC13 SGTC_919 tnp00227 403.569 nM 0.347799810292265 0.352748788484287 no 1170 0.363995266072114 1714 1269246 A methoxyflavone. YNL221C POP1 SGTC_196 k015-0023 18.111 µM 0.346986783136601 0.35304393583547 no 1171 0.364300624085335 1693 5211998 SGTC_1145 3546-0597 10.2 µM 0.346889814916685 0.353079143411268 no 1172 0.364337049315461 1704 875334 SGTC_2675 theaflavin digallate 100 µM 0.346418792534136 0.353250181828812 no 1173 0.36451400201626 1718 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1315 1237-0019 3.69 µM 0.346263896251747 0.353306434499352 no 1174 0.364572199437756 1784 825140 SGTC_469 w7 172 µM 0.345783354192426 0.353480970208315 no 1175 0.364752767907699 1757 45115570 A P450 inhibitor. SGTC_1723 st034307 2.5525 µM 0.345621384800171 0.353539805391374 no 1176 0.364813636284918 1667 867466 SGTC_2319 6033012 152.6 µM 0.344135554106072 0.354079694700075 no 1177 0.365372172852616 1627 847246 SGTC_2181 6316240 54.2555 µM 0.342864463738517 0.354541789251733 no 1178 0.365850213443755 1652 12779990 SGTC_2104 5389443 200 µM 0.342492824178076 0.354676936281096 no 1179 0.365990021659543 1786 2244536 SGTC_2337 9009472 200 µM 0.342212397680933 0.354778925716642 no 1180 0.366095527937426 1801 5742383 SGTC_1198 1612-1005 86.7 µM 0.341921373348548 0.354884780528387 no 1181 0.366205032198971 1809 6998509 SGTC_415 dibenzyl ketone 100 µM 0.339037616306656 0.355934299112452 no 1182 0.367290696425128 1826 7593 SGTC_841 0251-0215 91.2 µM 0.337451689211274 0.356511949898771 no 1183 0.367888212439034 1755 3888614 SGTC_1864 st057645 30.4 µM 0.337425287057908 0.356521569288008 no 1184 0.367898162460155 1796 688666 SGTC_3025 9087895 49.47 µM 0.337160311321304 0.356618115889455 no 1185 0.367998027184118 1818 17173641 SGTC_2075 5212009 200 µM 0.33711899142437 0.356633172041869 no 1186 0.368013600735395 1805 780898 SGTC_1587 estradiol valerate 56.1 µM 0.336710089294983 0.356782179923182 no 1187 0.368167728452694 1851 13791 A steroid. SGTC_1615 st002656 86.5 µM 0.33599592461354 0.357042480834223 no 1188 0.36843696984795 1698 1584458 SGTC_1699 st031318 29.054 µM 0.335323105306309 0.357287772953031 no 1189 0.368690683074574 1784 5340658 SGTC_263 alizarin 107.927 µM 0.33519708430841 0.35733372343637 no 1190 0.368738210662634 1749 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2816 7982706 58.44 µM 0.334872459670244 0.357452099420171 no 1191 0.368860648918483 1703 2981853 SGTC_64 000l-0018 272.079 µM 0.333587361427782 0.35792085140101 no 1192 0.369345478299246 1697 6811119 SGTC_2015 5119600 184 µM 0.333432124526411 0.357977490079866 no 1193 0.369404058656364 1840 2828786 SGTC_1885 st057546 99.9 µM 0.332620835664903 0.358273542247537 no 1194 0.369710256761324 1815 702008 SGTC_631 k072-0230 41.5 µM 0.332585081716355 0.358286591392147 no 1195 0.369723752983596 1770 5773147 SGTC_1120 ficusin 1.78878 µM 0.330842670839736 0.358922720667625 no 1196 0.370381663744787 1828 6199 A DNA cross-linker. SGTC_381 3461-2219 42.7 µM 0.329284325482117 0.359491981940362 no 1197 0.370970395284253 1849 2883159 SGTC_2182 6325192 200 µM 0.329031041047114 0.359584535879076 no 1198 0.371066112883377 1780 736248 SGTC_3182 9108849 49.47 µM 0.328569844674422 0.359753085115336 no 1199 0.371240422045555 1767 17133045 SGTC_1767 st044992 70.3 µM 0.327562814724828 0.360121209952734 no 1200 0.3716211207668 1667 9600693 SGTC_1186 1319-0216 26 µM 0.32738464931451 0.360186352728125 no 1201 0.371688487702768 1884 4565136 SGTC_1219 1469-0211 33.1 µM 0.326983199902596 0.360333149906405 no 1202 0.371840295970522 1839 6822282 SGTC_1014 4130-3005 69.3 µM 0.326264072023325 0.360596163384644 no 1203 0.372112284296667 1702 743608 SGTC_550 4123-0385 25.7 µM 0.325163647399355 0.360998759810402 no 1204 0.37252861007242 1713 5731123 SGTC_295 k015-0027 31 µM 0.325141604425044 0.361006825929522 no 1205 0.3725369511572 1768 3887424 SGTC_3123 9126162 49.47 µM 0.324996466647845 0.361059937301905 no 1206 0.372591872938012 1737 25239884 SGTC_2303 7774051 200 µM 0.324845842388572 0.361115059217089 no 1207 0.372648873605277 1832 2953184 SGTC_859 0439-0102 54.6 µM 0.324786318890681 0.361136843018614 no 1208 0.372671399823398 1861 610143 SGTC_1664 st014217 9.02 µM 0.324445513925866 0.361261576005969 no 1209 0.372800383270468 1795 3982782 SGTC_588 3970-1144 52.9 µM 0.32353066345879 0.361596479814041 no 1210 0.373146694515472 1811 1888707 SGTC_866 0495-0101 262 µM 0.322455645998217 0.361990152261426 no 1211 0.373553767021672 1659 635694 SGTC_562 3772-2733 112 µM 0.321619613016456 0.362296409347076 no 1212 0.373870441824095 1841 2876874 YIL048W NEO1 SGTC_1988 st071872 53.4 µM 0.32155599830111 0.362319716414221 no 1213 0.373894541464639 1882 16414116 SGTC_1983 st071813 46.9 µM 0.318585020224959 0.363408786232036 no 1214 0.375020607065842 1762 11838595 SGTC_308 4092-1169 104 µM 0.318337525846153 0.363499560089431 no 1215 0.375114461080841 1751 2268590 YDL196W YDL196W SGTC_2363 9053361 176 µM 0.318135034511963 0.363573833818579 no 1216 0.37519125468763 1862 6469797 YMR079W SEC14 SGTC_1950 st077106 7.18 µM 0.317741230672223 0.363718295569658 no 1217 0.375340616562157 1715 13831864 SGTC_1153 4055-0057 267 µM 0.317104682002652 0.363951846029866 no 1218 0.375582086181282 1719 882706 SGTC_33 0986-0033 35.816 µM 0.316089533895754 0.364324409624297 no 1219 0.375967275273656 1782 2848082 SGTC_2873 9040596 71.43 µM 0.314967435133737 0.364736373755308 no 1220 0.376393189684547 1701 6463863 SGTC_2346 9031566 143.75 µM 0.314845802857258 0.3647810388754 no 1221 0.376439366633944 1837 4771086 SGTC_940 3232-1287 54.8 µM 0.314799072922039 0.36479819926727 no 1222 0.376457107838115 1886 1585493 YIL048W NEO1 SGTC_1348 1493-0373 93.8 µM 0.314210679293563 0.365014295175763 no 1223 0.376680516119421 1788 3010129 SGTC_2838 9002687 71.43 µM 0.314128181694219 0.365044597018642 no 1224 0.376711843091213 1687 6457060 SGTC_742 0kpi-0133 140 µM 0.311584408608295 0.365979352298707 no 1225 0.377678192443881 1883 2728852 SGTC_2087 5276107 200 µM 0.310089171974069 0.366529175833452 no 1226 0.378246573112006 1724 144405 SGTC_86 0417-1630 471.922 µM 0.305966522150966 0.368046559542375 no 1227 0.379815067806484 1837 3634867 SGTC_815 1582-0027 36.9 µM 0.305291104266036 0.368295351174337 no 1228 0.380072225258724 1808 3128206 SGTC_1643 st009866 20.2 µM 0.304203810908462 0.368695974020022 no 1229 0.380486310829243 1865 3156273 YOR207C RET1 SGTC_3237 9133362 49.47 µM 0.303947985448645 0.368790255931077 no 1230 0.380583759501672 1828 43845137 SGTC_729 4092-0585 94.1 µM 0.302599247414523 0.369287450274187 no 1231 0.381097644036324 1714 2169061 SGTC_1141 3253-0389 52.6 µM 0.29824855072413 0.370892763729005 no 1232 0.382756734403688 1873 5402031 SGTC_1847 st056231 15 µM 0.296816045839205 0.371421820910012 no 1233 0.383303477215994 1741 5393180 SGTC_258 haloperidol 50.781 µM 0.296089118565202 0.371690384975257 no 1234 0.383581011873343 1742 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_745 0469-0705 296 µM 0.295636945832458 0.371857472197113 no 1235 0.383753677728036 1904 3486736 SGTC_894 0960-0238 55.9 µM 0.293915168449064 0.372493925427114 no 1236 0.384411363515597 1905 6741907 YDL195W SEC31 SGTC_2197 6588183 93.1375 µM 0.293551489490547 0.37262840359727 no 1237 0.384550324516379 1834 884136 SGTC_2551 apiole 73.87 µM 0.293441686631762 0.372669008634583 no 1238 0.384592282885183 1834 10659 A possible DNA adduct former. SGTC_2582 agaric acid 100 µM 0.292335203392244 0.373078264439779 no 1239 0.385015172679525 1731 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_771 0250-0039 27.3 µM 0.291913354559862 0.373234331736906 no 1240 0.385176436263782 1799 3005115 SGTC_1881 5652484 16 µM 0.29155369065908 0.373367409509612 no 1241 0.385313943593701 1907 2255129 SGTC_1813 st051246 8.6015 µM 0.28848363191732 0.374503962683062 no 1242 0.38648827901736 1915 5291959 SGTC_16 erodoxin 22.806 µM 0.287387465225806 0.374910034709352 no 1243 0.386907828941522 1824 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1124 fisetin 1.16336 µM 0.287265795067858 0.374955115655763 no 1244 0.386954405479152 1761 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1051 3253-3903 78 µM 0.286560240109783 0.375216569914195 no 1245 0.387224530954796 1799 5509239 SGTC_107 0358-0022 2.6945 µM 0.286301596377879 0.375312428702134 no 1246 0.387323567773891 1892 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2058 5236698 133 µM 0.284346300145595 0.376037351216033 no 1247 0.388072503696407 1784 766665 SGTC_2725 haloperidol 53.21 µM 0.283511746332856 0.376346893932513 no 1248 0.388392289312327 1808 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_502 l-744,832 89.3 µM 0.283273039291027 0.376435446931705 no 1249 0.388483771371104 1922 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_869 0564-0080 44.1 µM 0.28120935603599 0.377201280894315 no 1250 0.389274914509177 1766 6843321 SGTC_2405 ticlatone 3.52 µM 0.280957832626994 0.377294654463959 no 1251 0.389371371144611 1576 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2511 berberine 10.47 µM 0.280934807090944 0.377303202641153 no 1252 0.389380201541068 1785 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1840 st055363 71 µM 0.280162030642236 0.37759012895917 no 1253 0.389676597880534 1737 676033 SGTC_257 daunorubicin 18.5 µM 0.28004291473349 0.377634361850296 no 1254 0.389722290181322 1939 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_311 1315-0136 58 µM 0.279638097680525 0.377784699930332 no 1255 0.38987758748221 1893 6759207 SGTC_2224 6650123 117.647 µM 0.27948979421327 0.377839780452871 no 1256 0.389934484566374 1825 2908370 SGTC_3052 9092717 49.47 µM 0.278825886972676 0.378086388787258 no 1257 0.390189223528192 1794 25237534 SGTC_1059 3448-6867 171 µM 0.2787744238056 0.378105506855946 no 1258 0.39020897174211 1978 3934407 SGTC_2088 5278280 127.392 µM 0.278223098131742 0.378310337728226 no 1259 0.390420552417433 1835 791502 SGTC_2643 anethole 100 µM 0.278217957074995 0.378312247916656 no 1260 0.390422525538894 1825 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_597 k018-0003 82.8 µM 0.27728369698405 0.378659426820108 no 1261 0.390781138441745 1908 6786234 SGTC_2320 7373003 200 µM 0.276731017636564 0.378864853240757 no 1262 0.390993326491489 1749 5415828 SGTC_2323 6148992 148.28 µM 0.27668961421687 0.378880243933948 no 1263 0.391009223654177 1783 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_452 diindolylmethane 8 µM 0.275546833987181 0.379305119832692 no 1264 0.391448074742952 1872 3071 Inhibits expression of several cancer promoting factors. SGTC_999 SEC7.066 22.7 µM 0.275539492578649 0.379307849777423 no 1265 0.391450894442037 1851 740511 YDR170C SEC7 SGTC_2853 9015042 58.44 µM 0.274766768674699 0.379595225207383 no 1266 0.391747715254364 1756 6457456 SGTC_2985 9022375 71.43 µM 0.274377326346425 0.379740083734028 no 1267 0.391897332800342 1835 4939335 SGTC_3187 9109394 49.47 µM 0.2725903352827 0.380404996203739 no 1268 0.392584071009145 1773 17098090 SGTC_1849 st056239 19.2 µM 0.270188040984052 0.38129941051068 no 1269 0.393507796293192 1720 5393181 SGTC_2797 7859098 81.82 µM 0.27002134810789 0.381361496644579 no 1270 0.393571915005633 1806 972681 SGTC_99 0109-0120 622.8 µM 0.269563315066236 0.381532110538159 no 1271 0.393748113088404 1908 759414 SGTC_386 1509-0011 3.07 µM 0.269277866328438 0.381638449711406 no 1272 0.393857931719512 1812 3107280 SGTC_1962 st076595 64.5 µM 0.268102712013174 0.382076327895014 no 1273 0.394310129172689 1817 279619 SGTC_1286 0929-0070 131 µM 0.267998746115491 0.382115074249035 no 1274 0.394350141948891 1901 1420408 SGTC_3094 9117742 49.47 µM 0.265017728773555 0.383226550461681 no 1275 0.395497902198956 1791 17149698 SGTC_3274 9138298 49.47 µM 0.263662731455121 0.383732081535564 no 1276 0.396019907775734 1940 17015756 SGTC_3035 9091303 49.47 µM 0.263502326537669 0.383791939549333 no 1277 0.396081715289769 1845 25237002 SGTC_3181 9108277 49.47 µM 0.261103625038933 0.384687388690669 no 1278 0.39700629812396 1818 17097298 SGTC_2152 5568786 200 µM 0.260956968689853 0.384742156368626 no 1279 0.397062845858842 1862 5399883 SGTC_1249 0481-0015 10.2 µM 0.260462233143337 0.384926928488801 no 1280 0.397253621880722 1794 4227577 SGTC_2035 5154463 94.595 µM 0.25965593507404 0.385228117891306 no 1281 0.397564592851133 1948 2769623 SGTC_2080 5212524 12.4 µM 0.255788055413125 0.386673908642127 no 1282 0.39905724878195 2005 260183 SGTC_1034 k072-0165 12.7 µM 0.254489011088539 0.387159837967709 no 1283 0.399558896292911 1983 5835461 SGTC_1877 wortmannin 25 µM 0.25380992951651 0.387413930276315 no 1284 0.3998212009727 1964 312145 A covalent inhibitor of PI 3-kinase. SGTC_2109 5483026 200 µM 0.252493251195858 0.387906729841175 no 1285 0.400329914964089 1854 759335 SGTC_2455 5377712 9.75 µM 0.25157812462113 0.388249345115447 no 1286 0.400683584452648 1770 2243908 SGTC_506 n9-isopropylolomoucine 153 µM 0.251526779835931 0.388268570727254 no 1287 0.400703430116266 2029 6610355 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.248621579591566 0.389356842567495 no 1288 0.401826757218037 1820 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1370 2001-0092 44.6 µM 0.247821059347767 0.389656865960752 no 1289 0.402136430047421 1989 790957 SGTC_2340 7987427 183.45 µM 0.246296914314822 0.390228275125733 no 1290 0.402726199205071 1902 2239331 SGTC_2561 acetosyringone 100 µM 0.244386712248034 0.390944753758756 no 1291 0.403465665964304 2000 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1565 sinapyl alcohol 95.1 µM 0.24434290209586 0.390961190424854 no 1292 0.40348262956584 1813 5280507 A phenol propionate derived from cinnamic acid. SGTC_1133 3473-0247 50 µM 0.244203073409875 0.391013652568569 no 1293 0.40353677343901 1763 711311 SGTC_914 3820-6779 408 µM 0.243428226725105 0.391304402214986 no 1294 0.403836839781349 1851 2893481 SGTC_2871 9038510 12.99 µM 0.241465123336002 0.392041299012019 no 1295 0.404597322191689 2018 4945164 SGTC_2529 gangaleoidin 93.61 µM 0.239194772280544 0.39289401137392 no 1296 0.40547727807272 1892 4565183 SGTC_247 mechlorethamine 29.705 µM 0.238299820685912 0.393230284319075 no 1297 0.405824280207537 1913 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1857 st056007 79.3 µM 0.235989702058595 0.394098665887364 no 1298 0.406720330547177 1997 619834 SGTC_1692 fluoroquinolonic acid 71 µM 0.235207142355791 0.394392952438314 no 1299 0.407023981345503 1949 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1287 0971-0001 34.6 µM 0.234067505379064 0.394821627958385 no 1300 0.407466286097209 1910 4665869 SGTC_2567 aureobasidin a 60 nM 0.233517653608193 0.395028500801771 no 1301 0.407679731420777 1908 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_49 0717-0965 32.132 µM 0.23255674104636 0.395390099644226 no 1302 0.408052810975718 1973 5889349 YGL099W LSG1 SGTC_677 0929-0063 136 µM 0.232039629430739 0.39558473005606 no 1303 0.408253616916908 1916 1539583 SGTC_2 0422-0095 29 µM 0.231268505443801 0.395875013976642 no 1304 0.408553106253729 1915 6790840 SGTC_1184 1269-1718 139 µM 0.23023858179401 0.396262811179935 no 1305 0.408953191555205 2005 5403821 SGTC_883 0850-0245 24.6 µM 0.22990610744964 0.396388019700492 no 1306 0.409082365191604 1977 6823229 YPR165W RHO1 SGTC_1630 st005209 31.3 µM 0.22823524563006 0.397017421199049 no 1307 0.409731681191567 2062 3367314 SGTC_2467 5474540 200 µM 0.227687130088221 0.397223950868076 no 1308 0.409944739187674 1922 5413519 SGTC_743 1275-0778 158 µM 0.227090130379239 0.397448932858325 no 1309 0.410176829200806 1996 2849257 YMR203W TOM40 SGTC_279 1273-0055 2.93 µM 0.226533346702297 0.397658790010717 no 1310 0.410393313162536 2029 2847562 SGTC_1070 indatraline 8.81 µM 0.225220924258139 0.398153571818763 no 1311 0.410903706184928 1864 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_993 3909-8757 62.7 µM 0.22382123543636 0.398681433457435 no 1312 0.411448202814483 1901 4288324 YLR208W SEC13 SGTC_1328 1441-0025 69.2 µM 0.222347564342483 0.399237396220821 no 1313 0.412021663834366 1832 4562601 SGTC_799 1310-0557 151 µM 0.222266349013809 0.399268041778716 no 1314 0.412053273257645 1924 5354492 SGTC_559 1550-0661 158 µM 0.21945082332966 0.400330826659922 no 1315 0.413149441719895 1954 5830875 SGTC_704 1310-0270 142 µM 0.219050043833417 0.4004821703136 no 1316 0.413305532455319 1865 5718033 SGTC_3039 9090270 49.47 µM 0.218081328514904 0.400848041401776 no 1317 0.413682872490025 2054 17173750 SGTC_2389 9091542 195.52 µM 0.216270895702365 0.401532051139343 no 1318 0.41438829704236 1908 3626624 YOL127W RPL25 SGTC_695 3505-6186 243 µM 0.2161872986956 0.4015636426976 no 1319 0.414420876816494 1956 1819379 SGTC_878 0828-0289 13.7 µM 0.216098744402103 0.40159710833103 no 1320 0.4144553892073 1881 745350 YLR208W SEC13 SGTC_1243 0416-0003 5.65 µM 0.215502931582476 0.401822291246076 no 1321 0.41468761334326 1894 2141977 SGTC_767 0929-0023 86 µM 0.215397426244677 0.401862169583983 no 1322 0.414728738236925 1989 1204563 SGTC_3099 9120367 49.47 µM 0.215328278739418 0.401888306138979 no 1323 0.414755691729073 1932 24824940 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.214891699103719 0.402053335778725 no 1324 0.414925878435188 2002 688801 SGTC_2471 5466956 24.79 µM 0.214280706198679 0.402284323963909 no 1325 0.415164081418164 1960 724419 SGTC_1258 0671-0043 57.1 µM 0.214264978355828 0.402290270385429 no 1326 0.415170213520275 1884 4298767 SGTC_1116 jasmonic acid  1.58368 µM 0.2128148675043 0.402838628844551 no 1327 0.415735683391292 1994 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1906 st060206 94.7 µM 0.212802235610909 0.402843406428149 no 1328 0.415740609959118 2028 5133468 SGTC_1794 st048918 76.9 µM 0.20891357290417 0.404314847000368 no 1329 0.417257854151776 2049 672303 SGTC_2417 cerulenin 830 nM 0.20889740158276 0.404320968948761 no 1330 0.417264166325497 2059 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_17 0960-0276 49.807 µM 0.208372646714379 0.404519637173015 no 1331 0.417469006165468 1988 6821114 SGTC_2189 6047310 154.431 µM 0.207878478031926 0.404706748209263 no 1332 0.417661927064161 1933 711535 SGTC_1760 st045453 10.4495 µM 0.207868392085611 0.40471056735877 no 1333 0.417665864771992 2059 3323419 YIL048W NEO1 SGTC_1949 st076024 69.1 µM 0.207131906636 0.404989469820336 no 1334 0.417953422251436 1826 2921930 SGTC_2178 5812956 200 µM 0.207106773453847 0.404998988452647 no 1335 0.417963236165954 2027 5403383 SGTC_36 0335-0881 14.2 µM 0.206647156103219 0.405173068182163 no 1336 0.418142714897902 1946 23828853 SGTC_1651 st011928 86.1 µM 0.206577937489746 0.405199286306993 no 1337 0.418169745966726 1982 720198 SGTC_1657 st012939 43.4 µM 0.206133013352089 0.40536782159941 no 1338 0.418343505779324 2041 24207257 SGTC_3000 9075062 71.4286 µM 0.205817309115583 0.405487419610969 no 1339 0.418466809969623 1916 17057871 SGTC_2766 oltipraz 83.91 µM 0.205138603487978 0.405744563045608 no 1340 0.418731918250223 2027 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3293 9120939 62.045 µM 0.204504596569807 0.405984808082984 no 1341 0.418979600177862 1980 934087 SGTC_2348 9022543 33.42 µM 0.204256524621587 0.406078819940533 no 1342 0.419076521019082 1947 3162678 YDL140C RPO21 SGTC_1851 st056236 18.9 µM 0.203575337827473 0.406336997224286 no 1343 0.419342683554386 2057 5393171 SGTC_2626 ethyl orsellinate 100 µM 0.202278201841726 0.406828738553646 no 1344 0.41984962007396 1931 75653 A natural product. SGTC_509 pifithrin 175 µM 0.201965702527127 0.406947228331902 no 1345 0.41997176852258 2035 4817 A p53 inhibitor. SGTC_2043 5101342 149 µM 0.201539461436988 0.407108859096085 no 1346 0.420138388316354 1970 678451 SGTC_2815 7968870 71.43 µM 0.20062514302458 0.407455622275788 no 1347 0.420495848245827 1922 2977326 YHR190W ERG9 SGTC_3248 9135562 49.47 µM 0.19984464743651 0.407751689386031 no 1348 0.420801040989364 1928 17650701 SGTC_2864 9034755 47.6 µM 0.199742478024406 0.40779044943785 no 1349 0.420840995240223 2093 4930451 SGTC_641 4092-0595 30 µM 0.199449255370354 0.407901694447391 no 1350 0.420955667075207 2006 786260 SGTC_579 4491-1009 110 µM 0.19912518039328 0.40802465308067 no 1351 0.421082412261619 2127 1271041 SGTC_333 3486-0131 40.1 µM 0.198632092337287 0.408211755041139 no 1352 0.421275273869044 2055 6744690 SGTC_3012 9080433 71.4286 µM 0.198272852041051 0.408348081732354 no 1353 0.421415795478822 2078 17688859 SGTC_2897 9048598 12.99 µM 0.197991040673669 0.408455032988285 no 1354 0.421526036742113 1944 6467404 SGTC_59 0330-0160 1.33 µM 0.19725892804197 0.408732911562052 no 1355 0.421812459243609 1987 4293482 SGTC_1330 1469-0054 61.8 µM 0.196653564139602 0.408962716414924 no 1356 0.422049325423394 2080 7102664 SGTC_3266 9136860 49.47 µM 0.196542193743646 0.409004997631478 no 1357 0.422092905393781 1954 4871271 YPR165W RHO1 SGTC_1687 st020778 55.3625 µM 0.195577289601135 0.409371362962205 no 1358 0.422470518627492 1972 4259299 SGTC_1277 0873-0036 22 µM 0.19522108600208 0.409506630254553 no 1359 0.422609936195358 2025 5965735 SGTC_3255 9139072 49.47 µM 0.193598554550316 0.410122917980709 no 1360 0.423245115040597 1965 17646060 SGTC_135 0933-0004 26.348 µM 0.193229339795414 0.41026318825509 no 1361 0.423389680939331 1899 21230617 YGL099W LSG1 SGTC_2753 fluvastatin 17.09 µM 0.192677797459035 0.410472748918974 no 1362 0.423605656340213 1981 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1378 2093-0007 380 nM 0.192107966113798 0.410689285411934 no 1363 0.423828817538988 1955 3618014 SGTC_1404 3909-7820 48.3 µM 0.190726797935426 0.41121424356491 no 1364 0.424369821180168 2082 23741373 SGTC_2124 5246320 200 µM 0.190413000316225 0.411333534818813 no 1365 0.424492755628496 1971 579342 SGTC_1211 1056-0033 32.3 µM 0.189042069793501 0.411854794820516 no 1366 0.425029922140387 2096 6741922 SGTC_1879 gemcitabine 100 µM 0.189020975020178 0.411862816766787 no 1367 0.425038188715658 1998 60750 A nucleoside analog which inhibits DNA replication. SGTC_176 1486-1328 72.834 µM 0.188080320146591 0.412220567550687 no 1368 0.425406844016949 1929 22310231 SGTC_1503 4585-0012 61.3 µM 0.186679873260135 0.412753321959195 no 1369 0.425955818744533 2044 2922052 SGTC_2674 ligustilide 100 µM 0.186628339575073 0.412772929343804 no 1370 0.425976022676993 2006 5319022 A signalling regulator. SGTC_1939 st074455 53.6 µM 0.186297373438508 0.412898859549159 no 1371 0.426105783551226 2096 1644229 SGTC_1986 st071812 45 µM 0.183827555604564 0.413838889445726 no 1372 0.427074369127853 2065 11838594 SGTC_68 0986-0284 82.829 µM 0.182446858371681 0.414364608041024 no 1373 0.427616027592351 1783 423278 YIL048W NEO1 SGTC_385 1494-0393 12.4 µM 0.181868109063712 0.414585020135614 no 1374 0.42784311617846 2020 3090647 SGTC_696 1560-0013 611 µM 0.181333960823013 0.414788470135972 no 1375 0.428052725493217 2043 1650269 SGTC_2900 5328528 85.29 µM 0.180939322354927 0.414938797394787 no 1376 0.428207601725132 2022 795359 SGTC_1078 idebenone 36.1 µM 0.178293051714906 0.415947146111307 no 1377 0.429246417659885 2020 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2327 6189656 200 µM 0.176178935124436 0.416753118227309 no 1378 0.430076684633674 2070 5349088 SGTC_1013 4112-3890 241 µM 0.17589440876811 0.416861616012628 no 1379 0.43018844901294 1962 705171 SGTC_782 0083-0095 30.5 µM 0.174058702717488 0.417561773489554 no 1380 0.430909664084044 2131 3591729 An indicator and reagent. SGTC_1335 1486-0900 202 µM 0.173523020819691 0.417766137540755 no 1381 0.431120167174395 2105 X1335 SGTC_3203 9113543 49.47 µM 0.173355012220864 0.417830237840452 no 1382 0.431186192347568 2003 17018012 SGTC_1676 st018489 23.4 µM 0.173264442105686 0.417864793950926 no 1383 0.431221786011401 1944 3696235 SGTC_1139 k015-0024 46.9 µM 0.173106865854728 0.417924917085448 no 1384 0.431283714128116 2122 2766652 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.172521190279362 0.418148398092872 no 1385 0.431513901841083 1882 641818 YHR062C RPP1 SGTC_2512 diallyl trisulfide 49.23 µM 0.171485878201995 0.418543515179407 no 1386 0.431920866765053 2122 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1271 0832-2808 169 µM 0.16811063426205 0.419832213986603 no 1387 0.433248121741754 2109 3663794 SGTC_1 0258-0098 57.368 µM 0.167712862522106 0.419984143774873 no 1388 0.433404588347563 1998 6790032 YDR047W HEM12 SGTC_820 1582-0060 59.9 µM 0.16764421750659 0.420010364096271 no 1389 0.433431591454809 1985 3848840 SGTC_2366 9070441 60.58 µM 0.165040170478607 0.42100529253618 no 1390 0.434456182049926 2018 6837235 SGTC_1278 0874-0585 172 µM 0.16345074315656 0.421612813609646 no 1391 0.435081776385532 2040 766306 SGTC_2710 st078562 53.7235 µM 0.162496090415444 0.421977796888873 no 1392 0.435457603379482 2096 17250908 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.162081919266281 0.422136163859713 no 1393 0.435620672129554 2072 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1901 st060216 58.6 µM 0.162021462963968 0.422159281640547 no 1394 0.43564447608875 2075 688792 SGTC_2806 7952793 58.44 µM 0.161940846299088 0.422190108924776 no 1395 0.435676218316742 2044 2972490 SGTC_2589 lobaric acid 100 µM 0.16136802400747 0.422409166130941 no 1396 0.435901774867541 1973 73157 A novel microtubule depolymerizer. SGTC_636 0kpi-0074 126 µM 0.160157992004233 0.422871982232716 no 1397 0.436378309843494 2021 616434 SGTC_2773 thioridazine 9.09 µM 0.160101968111933 0.422893412976639 no 1398 0.436400375423075 2153 5452 An antipsychotic. SGTC_346 4513-0042 7.16 µM 0.160034087295989 0.422919379639299 no 1399 0.43642711123776 2016 2827372 SGTC_1501 4491-0275 38.4 µM 0.1599700724017 0.42294386776558 no 1400 0.436452324670896 2141 5104718 SGTC_1371 2421-0008 32.7 µM 0.158751052718071 0.423410245766409 no 1401 0.436932506954206 1990 2827552 SGTC_901 1112-0062 60.1 µM 0.158276144691462 0.423591967289735 no 1402 0.437119602482749 2025 1908457 SGTC_2265 7929201 200 µM 0.157378373004197 0.423935540153995 no 1403 0.437473328447471 2130 1265108 SGTC_2833 9001315 45.46 µM 0.15493354909273 0.424871454798903 no 1404 0.438436852316885 1979 2989378 SGTC_1908 st060353 56.5 µM 0.154919198177004 0.424876949796888 no 1405 0.438442509206086 2158 4227716 SGTC_18 0111-0177 500 nM 0.153883204872197 0.425273672466689 no 1406 0.43885091346637 2082 721752 SGTC_2882 9058044 58.44 µM 0.152931163861392 0.425638313233162 no 1407 0.439226279883124 1958 18076804 SGTC_244 nsc-207895 1.295 µM 0.150766825244786 0.426467511706393 no 1408 0.440079828346406 2066 42640 SGTC_159 3970-0959 50 µM 0.149832158608535 0.426825700657681 no 1409 0.440448518422715 2110 6615653 SGTC_656 4090-1979 187 µM 0.149306037480823 0.427027350740533 no 1410 0.440656075726637 2153 22330961 SGTC_858 0438-0351 2.77 µM 0.149016449231913 0.427138351371916 no 1411 0.440770326638134 2027 2799119 SGTC_2619 obliquin 87.91 µM 0.147504300493616 0.427718059102185 no 1412 0.441366992778459 2106 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3290 9121031 71.43 µM 0.146999807324656 0.427911499853082 no 1413 0.441566086200532 2016 17014854 SGTC_1636 st007707 68.9 µM 0.146548291873798 0.428084641744228 no 1414 0.441744284993421 2118 403051 SGTC_143 4032-1194 15.74 µM 0.146255360496649 0.428196979067946 no 1415 0.441859902003317 1988 1806963 SGTC_3148 9097893 49.47 µM 0.146185449429664 0.428223790378845 no 1416 0.441887495916895 2014 17174100 SGTC_1625 st003711 30.1 µM 0.144071005969475 0.429034848047107 no 1417 0.442722199858192 2109 24207034 YER133W GLC7 SGTC_1353 1498-1206 8.11 µM 0.14340356578059 0.429290926979083 no 1418 0.442985733498368 2097 6756808 SGTC_1148 3909-7663 27.7 µM 0.14321037550129 0.429365054475649 no 1419 0.443062017911061 2153 4084526 SGTC_1232 0279-0259 161 µM 0.143158158048105 0.429385090844589 no 1420 0.443082637208182 2005 1560000 SGTC_2867 9039098 71.43 µM 0.142875326966033 0.42949361917306 no 1421 0.443194322431187 2105 6463460 SGTC_1479 0549-0158 134 µM 0.142788504806224 0.429526935760014 no 1422 0.443228607943205 2055 5440202 SGTC_854 0422-0053 192 µM 0.142737679309405 0.429546439447923 no 1423 0.443248678801983 2136 3596728 SGTC_874 0599-0792 117 µM 0.140800404362885 0.430289973739327 no 1424 0.444013811806476 2176 765305 SGTC_3340 9146634 11.102 µM 0.140664061429125 0.430342312075394 no 1425 0.444067668784026 2049 4907387 SGTC_1996 st072960 66.8 µM 0.140187535590727 0.430525246963805 no 1426 0.444255909905501 2180 1719405 SGTC_429 1112-0049 25.5 µM 0.140147945685956 0.430540445918742 no 1427 0.444271549598797 1954 2836170 SGTC_511 blebbistatin 171 µM 0.140091151960237 0.43056224976991 no 1428 0.444293985683336 2144 3476986 A myosin inhibitor. SGTC_838 0109-0203 71.4 µM 0.139916473844844 0.430629312300506 no 1429 0.444362992539984 2138 759422 SGTC_564 3555-0129 330 µM 0.139710799851153 0.430708277352453 no 1430 0.444444246527642 2178 563260 SGTC_2798 7813637 45.45 µM 0.137725136733276 0.431470781162481 no 1431 0.445228826235236 2090 956368 SGTC_926 2268-1401 59.4 µM 0.135891207446203 0.432175245461034 no 1432 0.445953643218936 2178 2931578 SGTC_460 trequinsin 123 µM 0.131241169296112 0.433962418939878 no 1433 0.44779226460201 2189 5537 A vasodilator. SGTC_1964 st076914 61 µM 0.129741931032177 0.434538918747433 no 1434 0.448385303378045 2181 24208661 SGTC_94 0334-0113 514.748 µM 0.12971503017298 0.434549264168977 no 1435 0.448395945340987 2121 6795178 SGTC_617 3770-0098 35 µM 0.127649321255971 0.435343819323539 no 1436 0.449213248825914 2065 5962639 SGTC_227 fluconazole 33.516 µM 0.12729479555077 0.435480210582236 no 1437 0.449353539673909 2040 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1036 k216-0215 33.5 µM 0.127074181171928 0.435565088057292 no 1438 0.449440843108377 2165 622330 SGTC_2940 9060638 45.86 µM 0.126644637226454 0.435730355995583 no 1439 0.449610832980295 2058 4027022 SGTC_2539 epi(13)torulosol 80 µM 0.12511470811921 0.43631909043454 no 1440 0.450216369698929 2068 6708597 SGTC_3244 9134489 49.47 µM 0.124894107880502 0.436403991631913 no 1441 0.450303691538869 2058 16584271 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.124753306143818 0.436458182751987 no 1442 0.450359427399941 2158 5282309 SGTC_488 nitrendipine 139 µM 0.124608822419277 0.436513792218311 no 1443 0.450416621780428 2209 4507 Dihydropyridine L-type calcium channel blocker. SGTC_587 k089-0003 57 µM 0.122579254095356 0.437295072597195 no 1444 0.451220141683828 2205 9659696 SGTC_2764 methyldopa 94.69 µM 0.122088479497915 0.43748403264489 no 1445 0.451414472826218 2165 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_818 4072-2707 53.5 µM 0.120939587518289 0.437926439434747 no 1446 0.451869442990302 2166 882871 SGTC_670 4204-0025 119 µM 0.120872493347387 0.437952277963251 no 1447 0.451896014763641 2144 719039 SGTC_55 0767-0285 6.563 µM 0.120548065467203 0.438077221594011 no 1448 0.452024503242174 2181 3116166 SGTC_2168 5727979 200 µM 0.120030921877161 0.43827639663624 no 1449 0.452229326458486 2190 695210 SGTC_248 streptozotocin 5.23457 mM 0.119808448802392 0.438362085744465 no 1450 0.452317444489852 2206 5300 DNA alkylating agent. SGTC_1008 4106-0037 6 µM 0.119340400799274 0.438542371444227 no 1451 0.45250283849125 2163 2905394 SGTC_186 3455-3465 67.277 µM 0.118057815135757 0.439036471177732 no 1452 0.453010924137872 2176 755278 SGTC_586 0957-0265 8.15 µM 0.117771023586148 0.43914696698109 no 1453 0.453124544780398 2209 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2006 4011487 200 µM 0.116948248475957 0.43946399422928 no 1454 0.45345053184586 2172 45595294 SGTC_943 3253-1379 105 µM 0.11597562309844 0.439838811035696 no 1455 0.453835930678396 2156 668464 SGTC_214 4373-3496 70 µM 0.115896731869946 0.439869215406348 no 1456 0.453867192916447 2147 3779166 SGTC_853 0419-0306 21 µM 0.115774876638596 0.439916178632381 no 1457 0.453915481067525 2041 762713 SGTC_2803 7707263 71.43 µM 0.115095530180241 0.440178015460007 no 1458 0.454184701380058 2104 2199229 SGTC_3245 9134821 49.47 µM 0.11440708071556 0.4404433875017 no 1459 0.454457550626704 2153 17014901 SGTC_2216 7189485 200 µM 0.114284159387011 0.440490771987735 no 1460 0.454506269600078 2193 731273 SGTC_2029 5175081 200 µM 0.11407242358214 0.440572395233956 no 1461 0.454590191148737 2205 1380876 SGTC_1206 3978-0017 132 µM 0.114001668141469 0.440599671716454 no 1462 0.454618235540537 2111 3873677 SGTC_1943 st076331 65.2 µM 0.113998877452136 0.44060074754323 no 1463 0.454619341653544 2228 24208415 SGTC_1976 st070609 63.5 µM 0.112929929892656 0.441012865145174 no 1464 0.455043053742241 2196 682556 SGTC_2193 5925765 200 µM 0.112456061816799 0.441195578739445 no 1465 0.455230903139594 2181 877370 SGTC_3328 9140624 29.0385 µM 0.110834726486616 0.441820826091729 no 1466 0.455873703618053 2199 4904392 SGTC_2495 cafestol 54.53 µM 0.11008038153066 0.442111779148169 no 1467 0.45617281343072 2147 16667697 An anti-infammatory. SGTC_158 k038-0087 26.446 µM 0.109778836490537 0.442228094698783 no 1468 0.456292387809629 2093 X158 SGTC_895 0964-0006 13.7 µM 0.109736009229644 0.442244614944997 no 1469 0.456309370811559 2200 6738897 SGTC_692 k241-0027 77.8 µM 0.109194822239549 0.442453381799554 no 1470 0.456523983504008 2195 3600480 SGTC_2234 tolnaftate 200 µM 0.107952187853761 0.442932797520246 no 1471 0.457016809523399 2220 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3044 9093193 49.47 µM 0.107910037562533 0.442949060822019 no 1472 0.457033527398259 2081 25236277 SGTC_1870 st057514 26.5 µM 0.107197145186382 0.443224138320573 no 1473 0.45731629009608 2163 5393161 SGTC_602 3130-1533 38.1 µM 0.106219292287095 0.443601498286324 no 1474 0.457704182252815 2203 720941 SGTC_422 cantharidin 155 µM 0.106159350747155 0.443624631794233 no 1475 0.457727961022049 2190 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1911 st060208 74.3 µM 0.105121227442338 0.444025309796397 no 1476 0.458139807780433 2184 688783 SGTC_462 ag-879 158 µM 0.105005027396365 0.444070162374595 no 1477 0.45818590974553 2216 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2647 atorvastatin 60.16 µM 0.104478600160798 0.444273369355799 no 1478 0.458394774962608 2174 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2286 7945697 125 µM 0.103632747380962 0.444599908937661 no 1479 0.458730399461111 2116 1245733 SGTC_2334 9017922 200 µM 0.103260863649609 0.444743485737512 no 1480 0.458877967905159 2197 3163164 SGTC_3254 9136651 49.47 µM 0.103156163741944 0.444783909566562 no 1481 0.458919515253621 2223 16454030 SGTC_1745 st081495 74 µM 0.102283901769859 0.44512070548631 no 1482 0.459265666406729 2160 13842402 YBL026W LSM2 SGTC_2488 5268135 45.7 µM 0.100747680050336 0.445713964299373 no 1483 0.459875380344996 2177 1270356 YLR208W SEC13 SGTC_2881 9058953 51.95 µM 0.100380812086769 0.44585565957151 no 1484 0.460021001276895 2211 17122249 SGTC_165 k038-0023 64.381 µM 0.100331533963509 0.445874692769293 no 1485 0.460040561655515 2190 46368543 SGTC_2464 5717415 7.67 µM 0.0998569691475216 0.446057995210765 no 1486 0.460228939590078 2186 5285744 SGTC_1395 3486-0190 4.35 µM 0.0973281226838311 0.44703496511444 no 1487 0.461232911671395 2232 6748079 SGTC_70 0141-0289 43.283 µM 0.0971948532874339 0.447086460084351 no 1488 0.461285827588494 2118 352408 SGTC_3326 9140064 16.379 µM 0.0971746328166448 0.44709427330294 no 1489 0.461293856384071 2212 1868434 SGTC_1827 berberine 7.24 µM 0.0966840469161356 0.447283842676017 no 1490 0.461488654593735 2066 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1445 4239-0156 97.7 µM 0.0962728774897215 0.447442733672451 no 1491 0.461651925818283 2227 4008346 SGTC_1707 st032323 6.317 µM 0.094374403142994 0.448176483012146 no 1492 0.462405874185351 2159 3132057 YMR211W DML1 SGTC_110 0850-0284 111.64 µM 0.0939430279044568 0.448343231859146 no 1493 0.462577206813625 2258 3906265 SGTC_1954 st077032 68.9 µM 0.0937625744229035 0.448412989174892 no 1494 0.462648880975331 2017 698907 SGTC_426 0988-0037 14.6 µM 0.0934338515292073 0.448540066613138 no 1495 0.462779449251248 2277 5383008 SGTC_139 0099-0334 718.624 µM 0.09315368203192 0.44864837848592 no 1496 0.46289073535178 2258 97690 SGTC_931 2812-0076 566 µM 0.0926174523282398 0.448855692388721 no 1497 0.463103739195575 2226 3450959 SGTC_3332 9141069 11.198 µM 0.092563589821349 0.448876517159928 no 1498 0.463125135315534 2208 17332883 SGTC_2281 7943571 200 µM 0.0924678982354124 0.448913514585553 no 1499 0.463163147709301 2276 1244024 SGTC_2444 5485484 36.41 µM 0.0917541603811833 0.449189482444446 no 1500 0.463446682538198 2203 6790631 SGTC_1352 1496-0991 99 µM 0.0897876187163017 0.449949975628888 no 1501 0.464227993640366 2213 3000039 SGTC_3080 9117754 49.47 µM 0.0893167047008762 0.450132113014769 no 1502 0.464415109347955 2261 9550191 SGTC_210 3551-0445 56.827 µM 0.0892110690502225 0.450172971601573 no 1503 0.464457084312604 2213 2865180 YOR207C RET1 SGTC_1276 0871-0068 94.2 µM 0.0880665835049184 0.450615678479963 no 1504 0.464911877827028 2232 3414906 SGTC_684 1140-0066 328 µM 0.0880447568568369 0.45062412200524 no 1505 0.464920551706748 2160 6813534 SGTC_1914 st062367 72.6 µM 0.0871415880964226 0.450973527690825 no 1506 0.465279484288289 2183 978205 SGTC_2374 9071832 200 µM 0.0859724579085215 0.451425881312041 no 1507 0.465744155773884 2248 17381698 SGTC_544 k015-0020 52.4 µM 0.084187792621695 0.452116515941611 no 1508 0.466453561903905 2177 3008304 SGTC_1094 duloxetine 25.4 µM 0.0840126631821195 0.452184295850818 no 1509 0.466523181800464 2244 60834 A selective serotonin reuptake inhibitor. SGTC_902 1120-0002 2.07 µM 0.0825631740180757 0.452745341336803 no 1510 0.467099442069065 2253 3280475 SGTC_2431 5490079 200 µM 0.0824307856527734 0.452796588864018 no 1511 0.467152077966858 2203 5722345 SGTC_211 3455-0679 143.504 µM 0.0824173457180305 0.452801791505821 no 1512 0.467157421542812 2162 748649 SGTC_2105 5350118 200 µM 0.0823073018531827 0.452844390143197 no 1513 0.467201174042537 2182 2133313 SGTC_740 k014-0057 261 µM 0.0812421174782484 0.453256757356136 no 1514 0.467624702646412 2245 4012779 SGTC_1612 st002233 45.4 µM 0.0802502106200606 0.453640801815985 no 1515 0.468019128299715 2266 1035021 SGTC_1756 st041558 35.5 µM 0.0789510392966589 0.454143877827361 no 1516 0.468535783208516 2281 3955792 SGTC_3015 9080845 49.47 µM 0.0788568591395284 0.454180349927243 no 1517 0.468573238877118 2241 5296973 SGTC_819 1013-0258 27.7 µM 0.0785184143555183 0.454311418853767 no 1518 0.468707841452334 2213 5753198 SGTC_2848 9016370 25.97 µM 0.0778324201829842 0.454577097878629 no 1519 0.46898067854372 2262 7894410 SGTC_424 splitomicin 100 mM 0.0769097963452493 0.454934453349376 no 1520 0.469347652138154 2070 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_394 menadione 8.33 µM 0.075490651978627 0.455484194835737 no 1521 0.4699121674775 2293 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1016 4226-1401 38 µM 0.0732447143175337 0.456354389434121 no 1522 0.47080569251946 2280 2901613 SGTC_980 1473-0395 201 µM 0.0731295038056418 0.456399033738511 no 1523 0.470851531933194 2240 768876 SGTC_1518 st038567 90.8 µM 0.0726246729530431 0.456594663188689 no 1524 0.471052396191689 2273 77966 SGTC_2966 9084041 48.03 µM 0.0718264506972721 0.456904007614101 no 1525 0.471370011284335 2254 17741380 SGTC_1316 1272-0050 65.9 µM 0.0714161169353452 0.457063039241213 no 1526 0.471533291450747 2291 7340392 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0703886964994037 0.457461263110153 no 1527 0.471942143910213 2265 91467 include heat shock SGTC_3188 9110789 49.47 µM 0.0703355940299591 0.457481846569776 no 1528 0.471963276354081 2261 849217 SGTC_423 5-fluorouracil 457 µM 0.0683690521303003 0.458244192966839 no 1529 0.472745928494712 2265 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2903 5923464 63.88 µM 0.0682853848401296 0.458276630717724 no 1530 0.472779229089715 2291 2876576 SGTC_1296 1068-0102 11.9 µM 0.0677962803901677 0.458466261729947 no 1531 0.472973902385096 2262 767053 SGTC_827 3253-0474 693 µM 0.0666521885224305 0.458909875193527 no 1532 0.473429298825114 2282 5402065 SGTC_755 1995-0008 37.3 µM 0.0654681106302105 0.459369046835459 no 1533 0.473900647938853 2289 689533 SGTC_2572 astragaloside iv 100 µM 0.065372106525217 0.459406278495197 no 1534 0.473938866164844 2199 45006101 An anti-inflammatory agent. SGTC_2678 equilin 100 µM 0.0651538901559999 0.459490907008716 no 1535 0.47402573670144 2301 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_786 4544-0069 423 µM 0.0634221942004288 0.460162556842613 no 1536 0.474715157204864 2215 748821 YLR208W SEC13 SGTC_3302 9125395 16.351 µM 0.0629806430766123 0.460333833659072 no 1537 0.474890959151485 2206 17599668 SGTC_533 1222-0222 6.71 µM 0.0628517902128819 0.460383816821354 no 1538 0.474942262365578 2272 3982874 SGTC_1388 3346-4487 254 µM 0.0626576027352644 0.460459145038919 no 1539 0.475019579567172 2237 3345614 SGTC_1483 3453-0561 55.9 µM 0.0617211410670158 0.460822432355696 no 1540 0.47539245196405 2279 4546991 SGTC_2564 betulinic acid 100 µM 0.0615899769270912 0.46087331828246 no 1541 0.475444679521575 2303 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_808 0711-0032 135 µM 0.060323896703566 0.461364534631553 no 1542 0.475948834891684 2294 4252555 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0585510432178865 0.462052468789142 no 1543 0.476654852795123 2281 390807 SGTC_2912 7964298 10.93 µM 0.0579322585343453 0.462292607468915 no 1544 0.476901293834195 2247 2975850 SGTC_3298 9116858 71.43 µM 0.0559209142683057 0.463073266792265 no 1545 0.477702404860632 2278 2506942 SGTC_1397 3532-0190 20.1 µM 0.0544126498110553 0.463658760166141 no 1546 0.478303200347229 2264 5322280 SGTC_757 1066-0008 322 µM 0.0543004465333152 0.463702319532478 no 1547 0.478347896898914 2281 6842497 SGTC_2033 5192550 145 µM 0.0533855398102111 0.464057519263685 no 1548 0.478712363171369 2276 182073 SGTC_1773 st048542 73.5835 µM 0.053071101258684 0.464179602260314 no 1549 0.478837628423748 2267 3237138 SGTC_899 1083-0020 478 µM 0.0510838614344807 0.464951239753088 no 1550 0.479629347955532 2303 767123 SGTC_1406 3909-7906 11.9 µM 0.0501205990547907 0.465325318401731 no 1551 0.480013142347192 2314 X1406 SGTC_2097 5376186 200 µM 0.0499941873208695 0.465374412116459 no 1552 0.480063510188588 2313 742755 SGTC_1424 4048-1941 275 µM 0.0497524931305154 0.465468278806212 no 1553 0.480159812376679 2311 X1424 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0497119461769471 0.465484026200995 no 1554 0.480175968279294 2322 165521 SGTC_1845 st056753 3.01 µM 0.0490017397562763 0.465759860866349 no 1555 0.480458954740992 2312 5375839 SGTC_2528 xanthyletin 44.79 µM 0.0479712171000678 0.466160131286572 no 1556 0.480869590807423 2275 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1833 st055984 71 µM 0.0472572968468559 0.466437448692618 no 1557 0.48115408110592 2223 676288 SGTC_3249 9135183 49.47 µM 0.0458397821708937 0.466988120675536 no 1558 0.481718975267493 2291 4902779 SGTC_994 3910-0338 138 µM 0.0451645134551437 0.467250469391016 no 1559 0.481988089766032 2299 3479481 SGTC_3072 9116419 49.47 µM 0.0446287094701632 0.467458644778847 no 1560 0.482201629302174 2300 17170162 SGTC_1306 1185-0270 9.02 µM 0.0444974011629936 0.467509663224545 no 1561 0.482253961749217 2310 1548076 SGTC_1656 st012921 11 µM 0.0431107950292489 0.468048446699174 no 1562 0.482806607055946 2322 6732821 SGTC_829 1635-0120 117 µM 0.0430510156406013 0.468071676065256 no 1563 0.482830433460828 2314 285054 SGTC_1202 1988-0068 29.6 µM 0.0428550850929751 0.468147812473689 no 1564 0.482908526367614 2284 2850480 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.041346521891608 0.468734061988946 no 1565 0.483509822825858 2320 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1808 st050063 61.5 µM 0.0412540349637073 0.468770005967769 no 1566 0.483546688317384 2329 4011993 SGTC_2601 securinine 100 µM 0.0411474388375985 0.46881143363965 no 1567 0.483589177940604 2301 442872 A GABA receptor antagonist. SGTC_2957 9076800 11.52 µM 0.0404298721140247 0.469090318569828 no 1568 0.483875207604686 2306 16459615 SGTC_520 3584-0023 682 µM 0.0390191200641426 0.469638656603399 no 1569 0.484437572307096 2172 1340790 SGTC_3272 9137413 49.47 µM 0.035822843166056 0.470881212622715 no 1570 0.485711809271137 2346 17614870 SGTC_2036 5160441 105 µM 0.0352702149388493 0.471096076517386 no 1571 0.485932136791481 2312 134534 YIL048W NEO1 SGTC_3001 9076041 71.4286 µM 0.0345855525384973 0.471362287448645 no 1572 0.48620511100625 2336 16004211 SGTC_342 k048-0088 23.3 µM 0.0340963991890139 0.471552488252759 no 1573 0.486400139924047 2352 6820570 SGTC_283 0987-0079 11.7 µM 0.0332474848369728 0.471882592736129 no 1574 0.486738615805036 2324 411556 SGTC_1272 0839-0021 27 µM 0.0331544410043218 0.471918774462614 no 1575 0.486775714471159 2305 5027250 SGTC_1609 st001574 46.4 µM 0.0326848074065163 0.472101403256164 no 1576 0.486962969676019 2343 3960012 SGTC_1581 himbacine 57.9 µM 0.0325464528373001 0.472155207017889 no 1577 0.487018135813219 2338 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1341 1486-1360 280 µM 0.0307946959465802 0.47283647938468 no 1578 0.487716635218508 2357 3976547 SGTC_2012 4023501 200 µM 0.0307007751509347 0.472873008201047 no 1579 0.487754086487051 2318 3477460 SGTC_2856 9022925 19.48 µM 0.0303171766221125 0.473022204364528 no 1580 0.487907048952844 2322 4944862 SGTC_1775 st081588 35.1725 µM 0.0297293172173995 0.473250852744999 no 1581 0.488141465246251 2344 1426443 YGL099W LSG1 SGTC_2099 5377090 177.372 µM 0.0290573537287338 0.473512224266111 no 1582 0.488409424108757 2317 2243829 SGTC_647 0140-0236 81 µM 0.0280286703206889 0.473912370062832 no 1583 0.488819642258166 2323 990837 SGTC_3323 9138564 53.9225 µM 0.0280159786867596 0.473917307124982 no 1584 0.488824703499986 2363 43912313 YNL103W MET4 SGTC_1414 3917-0015 5.4 µM 0.0277363961008828 0.474026066130257 no 1585 0.488936197485601 2348 6618702 SGTC_2682 pyrogallin 40.03 µM 0.0263833860685027 0.474552420915515 no 1586 0.489475772767333 2370 822798 An ATP competetive kinase inhibitor. SGTC_2147 5545932 89.7195 µM 0.0258671973754601 0.474753243000142 no 1587 0.48968163199474 2330 797404 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0254188192471199 0.474927688740459 no 1588 0.489860450184388 2337 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1029 k015-0030 64.7 µM 0.0248087656760946 0.475165043549427 no 1589 0.490103749606524 2290 2208316 SGTC_175 3793-3120 23.7 µM 0.0228752802780051 0.475917366560585 no 1590 0.490874879357838 2350 5322297 SGTC_2390 9097792 176.6 µM 0.0221070893958706 0.476216295142387 no 1591 0.49118126566953 2352 4497149 SGTC_117 lucigenin 22.078 µM 0.0218951355393793 0.476298775789672 no 1592 0.491265802561747 2322 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2991 9074669 71.4286 µM 0.0216380761511252 0.47639881036246 no 1593 0.491368330129118 2366 17333109 SGTC_194 1486-1323 56.904 µM 0.0212782470743629 0.476538840221159 no 1594 0.491511848115356 2352 5178754 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0209281274906181 0.476675094347767 no 1595 0.491651494520953 2348 5379071 SGTC_2469 5655019 90.81 µM 0.0201983950696995 0.476959089076148 no 1596 0.491942554087139 2369 2788239 SGTC_2403 6032726 181.2 µM 0.0194022358748483 0.477268948889723 no 1597 0.49226011338745 2358 2881040 SGTC_1822 st052468 42 µM 0.0192302024766661 0.477335904945413 no 1598 0.492328731980989 2358 2873678 SGTC_732 3970-1727 52.7 µM 0.0188460796584043 0.477485409319852 no 1599 0.49248194704414 2361 1275699 SGTC_445 e6 berbamine 66 µM 0.0170066603214387 0.478201372946205 no 1600 0.493215651186501 2360 6610268 A calcium/calmodulin antagonist. SGTC_3346 9158254 43.5805 µM 0.0167234156297116 0.478311627577702 no 1601 0.493328633400472 2344 17639500 SGTC_2706 st078239 82.5 µM 0.0161353003670077 0.478540560130545 no 1602 0.493563225777964 2379 15434492 SGTC_3154 9100113 49.47 µM 0.0154541075734598 0.478805733332198 no 1603 0.493834948483353 2364 25237525 SGTC_2302 7771753 200 µM 0.0141430641071065 0.479316119692892 no 1604 0.494357921847842 2359 2203047 SGTC_2964 9083345 53.42 µM 0.0135439900511569 0.479549349256016 no 1605 0.494596894914395 2367 17741579 SGTC_600 1495-0418 41.6 µM 0.0131121139487129 0.479717490203699 no 1606 0.494769173248036 2377 5377768 SGTC_146 3448-8650 53.125 µM 0.0127592674444282 0.479854865489872 no 1607 0.494909926859566 2356 2891488 YIL048W NEO1 SGTC_2244 6635614 200 µM 0.0113664766832862 0.480397150069493 no 1608 0.495465529511891 2375 836499 SGTC_1091 telmisartan 47.6 µM 0.0104189926038276 0.480766074810819 no 1609 0.495843498533064 2357 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1628 st004252 77.7 µM 0.00969944077998192 0.481046259903892 no 1610 0.496130543649239 2382 692968 SGTC_1460 k062-0059 9.15 µM 0.00932341050275911 0.481192685444742 no 1611 0.496280551239112 2354 1373085 SGTC_2135 5326629 150.42 µM 0.00881172133222644 0.481391940396324 no 1612 0.496484677289563 2377 5020077 SGTC_748 act1.228 77.9 µM 0.00823970446448447 0.481614692830047 no 1613 0.49671287070651 2392 4421505 YNR035C ARC35 SGTC_188 3229-0966 278.469 µM 0.00755016992852719 0.481883216130084 no 1614 0.496987946608373 2396 5722370 SGTC_592 k241-0073 46.5 µM 0.00748349089408491 0.48190918317786 no 1615 0.497014546942917 2396 4230158 SGTC_904 1141-0088 396 µM 0.00734410589063805 0.481963464611231 no 1616 0.49707015198583 2376 1378119 SGTC_2090 5301565 104.445 µM 0.00623957387234624 0.482393620052853 no 1617 0.497510786322438 2394 2056344 SGTC_2999 9069765 71.4286 µM 0.00587935913601232 0.482533908653639 no 1618 0.497654488571817 2392 2097066 SGTC_2765 myclobutanil 7.74 µM 0.00428461480124924 0.483155020734258 no 1619 0.498290691230443 2385 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_301 4119-0100 24.5 µM 0.00339742841937192 0.483500574905727 no 1620 0.498644624766283 2396 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_251 melphalan 456.522 µM 0.000493600843904402 0.484631684922937 no 1621 0.499803081761721 2398 460612 A DNA alkylator. SGTC_1167 k781-0610 148 µM 0.000342101444433292 0.484690701021609 no 1622 0.499863521272291 2403 4525169 SGTC_643 k048-0106 28.4 µM -0.00159352110322439 0.485444745561422 no 1623 0.499364277326261 2413 6763920 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.00241995039243189 0.485766706827692 no 1624 0.49903458041426 2413 3256 An antibiotic and ribosome inhibitor. SGTC_1666 st014829 29 µM -0.00312836105094382 0.486042697654494 no 1625 0.498751966544094 2412 3858230 SGTC_698 k064-0052 127 µM -0.00337606536440801 0.486139202753315 no 1626 0.498653147343269 2415 5088751 SGTC_1142 3253-1408 9.78 µM -0.00392400212531195 0.486352680681304 no 1627 0.498434553661232 2401 256655 SGTC_1212 0520-0165 585 µM -0.00403671712934847 0.486396595297154 no 1628 0.498389587236719 2417 5403258 SGTC_2037 5169046 200 µM -0.00508729457348186 0.486805916057823 no 1629 0.497970471856008 2423 5718022 SGTC_2278 7948257 134.34 µM -0.00534659212095334 0.486906944434528 no 1630 0.497867028509099 2420 1247028 SGTC_1270 0831-1170 17.3 µM -0.00595263045179737 0.487143074379411 no 1631 0.49762525805754 2415 6764716 SGTC_449 xestospongin c 11.1929 µM -0.00605037588094167 0.487181159231068 no 1632 0.497586263975406 2425 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1696 st025591 34.7925 µM -0.00811150246844015 0.487984268993649 no 1633 0.496764014193873 2420 2787147 SGTC_302 1094-0063 18.9 µM -0.00959834256205103 0.488563640753099 no 1634 0.496170874125378 2433 5440289 SGTC_921 1561-0023 372 µM -0.0120035570878642 0.489500922819723 no 1635 0.495211388557534 2423 24050882 SGTC_1329 1447-1697 50.6 µM -0.0120936702299806 0.489536039945099 no 1636 0.495175441224451 2473 2840515 SGTC_3310 9130229 44.1445 µM -0.0122107330368333 0.489581659486052 no 1637 0.495128743369565 2466 7761258 SGTC_1128 3448-9350 235 µM -0.0126147917692597 0.489739122787393 no 1638 0.494967559676333 2440 619386 SGTC_1104 tacrolimus 29.8 µM -0.0130006597730213 0.489889498582368 no 1639 0.494813633241331 2430 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_468 gf-109203x 121 µM -0.0132780519934743 0.489997601400838 no 1640 0.4947029793089 2437 2396 A protein kinase C inhibitor. SGTC_534 k292-0788 63.4 µM -0.013348528586449 0.490025067026519 no 1641 0.49467486570778 2427 4146317 SGTC_1052 3253-3998 198 µM -0.0152378816069646 0.490761389169232 no 1642 0.493921200006645 2431 5450317 SGTC_245 methotrexate 289.6 µM -0.0157487292572473 0.490960483169453 no 1643 0.49371742574103 2442 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1839 st053978 48 µM -0.018144586797816 0.491894256275134 no 1644 0.492761754337931 2436 3788398 SGTC_2063 5246145 200 µM -0.0182933530919361 0.491952238687649 no 1645 0.492702415022455 2462 711240 SGTC_3104 9120930 49.47 µM -0.0186136844587586 0.492077090027161 no 1646 0.492574643054133 2473 17014836 SGTC_1892 st058411 7.36 µM -0.0187211097356078 0.492118959937411 no 1647 0.492531794035721 2442 3934738 SGTC_3353 9151644 39.2805 µM -0.020845327333428 0.49294690895443 no 1648 0.491684519799957 2481 4909158 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0209070636915909 0.492970972194934 no 1649 0.491659895922771 2448 5106787 A p450 inhibitor. SGTC_1523 st012844 44.7 µM -0.0210318822715621 0.493019623336931 no 1650 0.491610111460658 2507 4274103 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.021588601623536 0.493236619787295 no 1651 0.491388063000465 2466 688751 SGTC_1734 st037168 69.4 µM -0.0216601772004949 0.493264518454129 no 1652 0.491359515152048 2497 708907 SGTC_2980 9014342 25.29 µM -0.0227921725855251 0.493705750933044 no 1653 0.490908025888106 2537 2996599 SGTC_1319 1306-0155 43.7 µM -0.0228240125679729 0.493718161728598 no 1654 0.490895326876401 2457 3122360 SGTC_1409 3909-8004 61.9 µM -0.0239326184235578 0.494150285040231 no 1655 0.490453177994725 2463 2119279 SGTC_2044 5102272 200 µM -0.0286786784582314 0.496000322404691 no 1656 0.488560430749065 2487 592666 SGTC_3166 9102297 49.47 µM -0.0294733300510247 0.496310090960424 no 1657 0.488243544617151 2485 25237072 SGTC_2414 st077232 92.9 µM -0.029502471246389 0.496321450731918 no 1658 0.488231924015585 2463 729801 SGTC_693 4161-2696 114 µM -0.0295504168889252 0.496340140827695 no 1659 0.488212804807601 2489 805759 SGTC_624 k048-0052 28 µM -0.0301771526184533 0.496584454698322 no 1660 0.487962884900384 2483 6835531 SGTC_1482 3346-2049 8.48 µM -0.0304694333765169 0.496698391909745 no 1661 0.48784633534476 2514 3826804 SGTC_917 harmaline 728.087 nM -0.0317384791149199 0.497193095739435 no 1662 0.487340304218549 2504 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1178 0988-0033 191 µM -0.0320736560407459 0.497323756327755 no 1663 0.487206656016108 2506 5392207 SGTC_323 4013-0906 34.3 µM -0.0321492344781651 0.497353218787128 no 1664 0.487176520123184 2505 2910086 SGTC_2354 9060492 162 µM -0.0327438162571186 0.497585002867219 no 1665 0.486939441144394 2467 6471895 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0331758006693102 0.497753402606007 no 1666 0.486767197882794 2484 23847180 SGTC_3232 9132874 49.47 µM -0.0333521731464465 0.49782215770154 no 1667 0.486696874361656 2473 3784940 SGTC_526 4469-0568 170 µM -0.0335590647902806 0.497902810133727 no 1668 0.486614382716097 2464 2901964 SGTC_816 0325-0417 81.3 µM -0.0358559848892065 0.498798221983851 no 1669 0.485698596125156 2494 68101 SGTC_432 NS 1619 61.3 µM -0.036200035101705 0.498932344232064 no 1670 0.485561429001044 2602 4552 A K+/calcium channel activator. SGTC_967 1306-0166 352 µM -0.0373120509307735 0.499365845840383 no 1671 0.48511809846561 2475 4437607 SGTC_3132 9126706 49.47 µM -0.0375422754028467 0.499455595283824 no 1672 0.485026316496186 2573 850858 SGTC_155 k072-0202 43.6 µM -0.0384054575697135 0.499792093686061 no 1673 0.484682204841279 2455 5857737 SGTC_726 3448-4391 34.2 µM -0.0384851781990362 0.499823171568594 no 1674 0.484650424406727 2524 1356692 SGTC_2298 7976326 193.81 µM -0.0388463659360368 0.499963975159941 no 1675 0.484506439020391 2506 2235818 SGTC_789 1309-1135 70.6 µM -0.0389387764336632 0.5 no 1676 0.484469600437897 2485 3092424 SGTC_2493 resveratrol 26.09 µM -0.0394726316200607 0.499791884608864 no 1677 0.484256786654498 2462 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1820 st053765 18.6 µM -0.0395450862728426 0.499763639258573 no 1678 0.4842279039811 2510 3690829 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0396321933166042 0.499729681896902 no 1679 0.484193180519451 2472 15053 SGTC_133 0724-0033 378.92 µM -0.0405323659815191 0.499378763377188 no 1680 0.483834351956701 2470 280309 SGTC_1240 0356-0016 42.1 µM -0.0405693699563951 0.499364337953038 no 1681 0.483819601639079 2516 4305613 SGTC_310 1273-0058 1.06 µM -0.0407421412644285 0.499296985756703 no 1682 0.483750732799399 2479 2734232 SGTC_1011 4112-3381 17.4 µM -0.0410655805547907 0.499170898055748 no 1683 0.483621807091485 2606 2877139 SGTC_1698 5-fluorocytosine 1.055 µM -0.0411622883654484 0.499133198058078 no 1684 0.483583258850873 2486 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2212 7123476 200 µM -0.0414116573895127 0.499035985557564 no 1685 0.48348385975867 2474 1085715 SGTC_212 3807-4682 38.772 µM -0.0418026368866816 0.498883568610717 no 1686 0.483328016460297 2531 3125501 YBL034C STU1 SGTC_3325 9138760 55.175 µM -0.0421380191828731 0.49875282545016 no 1687 0.483194336074303 2501 43844959 SGTC_1796 st049173 110.4 µM -0.0427344505274238 0.498520317038347 no 1688 0.482956608547434 2476 94134 SGTC_2014 4013930 200 µM -0.0430202800753028 0.498408891521432 no 1689 0.482842683827833 2478 64556 SGTC_1663 st014140 55.4 µM -0.0431528582673104 0.498357208335449 no 1690 0.482789841853698 2481 4207120 SGTC_870 0573-2213 57.6 µM -0.043991672051854 0.498030212781242 no 1691 0.482455521091184 2483 3916321 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0445634959370727 0.497807298891895 no 1692 0.482227619879728 2499 5357218 A potent inhibitor of glutathione S-transferases. SGTC_861 0443-0273 110 µM -0.0452282911297984 0.497548142898192 no 1693 0.481962672128824 2556 6149169 SGTC_2801 7907800 81.82 µM -0.0464437133808252 0.497074339636066 no 1694 0.481478297921831 2528 6620925 SGTC_1837 st055472 66.5 µM -0.0465793609905958 0.497021460907094 no 1695 0.481424240858182 2599 676091 SGTC_1965 Pectolinarigenin 58.4 µM -0.0469184925230834 0.496889259439716 no 1696 0.481289094711012 2497 5320438 An anti-inflammatory. SGTC_1204 4049-0315 18.3 µM -0.047083882064726 0.496824786819868 no 1697 0.48122318666952 2704 588402 SGTC_1346 1488-2224 62.4 µM -0.0476561710859517 0.49660169614233 no 1698 0.480995132396748 2467 3722427 SGTC_2375 9072683 200 µM -0.05208322139007 0.494875977079324 no 1699 0.479231191105154 2489 16798029 SGTC_2428 5615643 7.78 µM -0.0526992843504731 0.494635834969616 no 1700 0.478985754620341 2541 2253075 SGTC_516 3992-2719 87.3 µM -0.0529301895691792 0.494545828323765 no 1701 0.478893765153094 2485 5350887 YDR037W KRS1 SGTC_1039 k821-0043 94 µM -0.0552956511262433 0.493623790348516 no 1702 0.477951463382998 2472 15992768 SGTC_1274 0865-0114 173 µM -0.0556194290856702 0.493497586832508 no 1703 0.477822493145134 2550 870624 SGTC_2067 5224629 34.075 µM -0.0566176351489186 0.49310850608428 no 1704 0.477424893130422 2559 2835000 SGTC_1799 st045822 46.1415 µM -0.0570943415369555 0.492922697764039 no 1705 0.477235021935974 2501 3674992 SGTC_2041 5107442 45.335 µM -0.0572231645919833 0.492872485995894 no 1706 0.477183712857701 2514 793005 SGTC_2250 alverine citrate 130 µM -0.0574397961580088 0.49278804908273 no 1707 0.477097431282892 2483 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2019 4016004 108 µM -0.058437740892074 0.492399082425307 no 1708 0.476699976619559 2553 45595336 SGTC_1982 st072467 71.9 µM -0.0584977700025351 0.492375685241711 no 1709 0.4766760693675 2495 3163533 SGTC_1443 4112-3303 14 µM -0.0586367360465246 0.492321521387377 no 1710 0.476620724937604 2519 704433 SGTC_2357 9067248 200 µM -0.0595907888518932 0.491949670558282 no 1711 0.476240777381858 2555 9150235 SGTC_1644 st010134 20.9 µM -0.0599349077512996 0.49181554876169 no 1712 0.476103738746179 2525 3818134 SGTC_307 1501-1223 22.3 µM -0.0621590527011371 0.490948701842998 no 1713 0.475218085305968 2544 2830329 SGTC_1282 0886-0010 32.4 µM -0.0621686169491717 0.490944974325076 no 1714 0.475214277088289 2528 2836211 YNL267W PIK1 SGTC_1060 3448-7350 82 µM -0.0627520127978056 0.490717606312974 no 1715 0.474981989374538 2534 570178 SGTC_2653 dihydrofissinolide 100 µM -0.0628817336907861 0.490667050341371 no 1716 0.474930340229025 2558 6857746 SGTC_2916 7875993 68.79 µM -0.0642733646333596 0.490124701242588 no 1717 0.474376280767462 2527 1299250 SGTC_1225 1216-0074 20.6 µM -0.0645401179489776 0.490020743679661 no 1718 0.474270082088511 2554 4241466 SGTC_2011 4012611 177 µM -0.0646333830244885 0.489984397112178 no 1719 0.47423295223008 2532 2049887 SGTC_2850 9015429 58.44 µM -0.0647511414846225 0.48993850528492 no 1720 0.474186071603987 2564 6457570 SGTC_328 k915-0120 63.5 µM -0.0648893764751104 0.489884633688107 no 1721 0.474131039556362 2627 6624543 SGTC_1673 st016611 27.3 µM -0.0658881700086316 0.489495399124685 no 1722 0.473733429541118 2684 5226799 SGTC_1058 3448-5425 97.3 µM -0.0666987971335331 0.489179501237924 no 1723 0.473410745964879 2514 7279705 SGTC_1448 4255-0083 152 µM -0.067755260443474 0.488767812270092 no 1724 0.472990229433476 2649 5399660 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.069183406908841 0.488211302683172 no 1725 0.472421815413385 2522 229346 A bile salt which induces apoptosis. SGTC_556 4058-0063 51.5 µM -0.0692746415401782 0.488175751813063 no 1726 0.472385505177126 2539 6615692 SGTC_1710 st031758 61.5 µM -0.0705405303946284 0.487682490059266 no 1727 0.471881721143654 2671 5394341 SGTC_2260 7964312 200 µM -0.0709226098419105 0.487533614006426 no 1728 0.471729674316406 2714 231951 SGTC_720 r052-1644 49.9 µM -0.0721550233200555 0.487053419921039 no 1729 0.471239269009643 2597 1422863 YOR257W CDC31 SGTC_2491 paeonol 100 µM -0.0725734787370388 0.486890378375193 no 1730 0.471072765977408 2537 11092 Increases levels of cortical cytochrome oxidase. SGTC_52 0329-0193 875 nM -0.0760252502609901 0.48554556094445 no 1731 0.469699504762683 2728 3739292 SGTC_620 0109-0052 432 µM -0.0774921437965422 0.484974105027336 no 1732 0.469116020412082 2550 493037 SGTC_2157 5649910 96.377 µM -0.0779713131034296 0.484787442256999 no 1733 0.468925436164659 2556 2858091 SGTC_3190 9110366 49.47 µM -0.0796638374440689 0.484128137999127 no 1734 0.468252310773349 2557 17123768 SGTC_1616 st002734 56.1 µM -0.0798833371871459 0.484042637426624 no 1735 0.468165021235508 2577 4026101 SGTC_1017 4239-0030 168 µM -0.080671272525877 0.483735723219103 no 1736 0.467851691768464 2578 1149593 SGTC_778 3456-2434 196 µM -0.0823868632106857 0.483067505065583 no 1737 0.467169541087377 2721 5539063 SGTC_2755 lomerizine 42.69 µM -0.0824967003394309 0.483024725386772 no 1738 0.467125871070088 2580 3949 A calcium channel blocker. SGTC_98 0074-0023 107.663 µM -0.082699521669397 0.48294573046952 no 1739 0.467045232611883 2618 3563821 SGTC_2973 9094665 17.96 µM -0.0833058072283766 0.482709598177734 no 1740 0.466804191423522 2760 25237061 YIL048W NEO1 SGTC_2921 7974240 10.71 µM -0.0838652974267832 0.482491696828062 no 1741 0.466581765483876 2638 2979074 YDR527W RBA50 SGTC_1941 st076221 61.8 µM -0.0839712204348849 0.482450444205267 no 1742 0.466539656849119 2696 2828568 SGTC_1298 1079-1278 263 µM -0.0846279436191752 0.482194681946757 no 1743 0.46627859147905 2579 2840950 SGTC_918 glabranin 770.725 nM -0.0857849872065209 0.481744086722721 no 1744 0.46581867047714 2603 124049 Also referred to as licorice root. SGTC_2986 9022445 71.43 µM -0.0861148255827958 0.481615639803955 no 1745 0.465687569147263 2543 6459286 SGTC_2565 isoliquiritigenin 100 µM -0.086339240137463 0.481528248522128 no 1746 0.465598372901929 2689 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_806 3966-4455 5.86 µM -0.088160189354414 0.480819169567834 no 1747 0.4648746791812 2588 714982 SGTC_90 0870-0863 4.608 µM -0.0896254854026082 0.480248626173663 no 1748 0.464292415741131 2563 1738164 SGTC_1392 3455-1037 33.9 µM -0.0904328260104361 0.479934288583809 no 1749 0.463971636083905 2678 981132 SGTC_1255 0566-0045 221 µM -0.0907229882978102 0.479821317106265 no 1750 0.463856351967057 2665 2788469 SGTC_2412 st077135 33.4 µM -0.0916513243774831 0.479459890653563 no 1751 0.46348753602983 2858 13258915 SGTC_1239 0337-0584 35.4 µM -0.092580874201513 0.479098008578171 no 1752 0.46311826932806 2662 914301 YML130C ERO1 SGTC_253 dyclonine 31.25 µM -0.0935315893690591 0.478727904469825 no 1753 0.462740627497718 2563 3180 An oral anasthetic. SGTC_1138 3761-0006 1.03 µM -0.0939372753894554 0.478569980438004 no 1754 0.462579491631328 2545 12061087 SGTC_585 0kpi-0023 191 µM -0.094810407230717 0.478230102181101 no 1755 0.462232710169096 2623 64601 SGTC_2627 acetyl isogambogic acid 100 µM -0.0949508365446796 0.478175439662318 no 1756 0.462176938581409 2659 6857789 A caspase activator and apoptosis inducer. SGTC_2917 7979103 53.79 µM -0.0951270417534748 0.478106851853333 no 1757 0.462106959627357 2662 2980565 SGTC_2116 5511452 16.8835 µM -0.0958186364842734 0.47783765515941 no 1758 0.461832307844687 2677 870744 SGTC_3300 9124615 50.48 µM -0.0966169499420579 0.477526931792583 no 1759 0.461515297681723 2717 24824903 SGTC_3060 1327-0027 12.5 µM -0.0970319067019589 0.477365425729947 no 1760 0.461350528055017 2624 16000455 YPR107C YTH1 SGTC_435 c-PAF 6.7 µM -0.098035919901211 0.476974667387945 no 1761 0.46095188538973 2572 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2739 tacrine 100.86 µM -0.0985740249775288 0.476765247907324 no 1762 0.460738247309105 2666 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2532 xanthone 78.9 µM -0.0988950427137108 0.476640317427902 no 1763 0.460610802476824 2653 7020 An insecticide. SGTC_2073 5212005 126 µM -0.0991729081167501 0.47653218239625 no 1764 0.460500492493349 2571 691789 SGTC_1170 0310-0127 64.8 µM -0.101051080682771 0.475801312183122 no 1765 0.459754955571466 2667 774975 SGTC_652 0437-0092 114 µM -0.101857803898949 0.475487409559357 no 1766 0.459434771655288 2588 3091274 SGTC_1155 4088-0394 48.2 µM -0.101999544589071 0.47543225865946 no 1767 0.459378518282444 2576 2326248 SGTC_319 1348-1596 45.5 µM -0.102483318389855 0.475244027199088 no 1768 0.459186526562518 2741 5380505 SGTC_190 3970-0790 3.722 µM -0.102838151793648 0.47510596864452 no 1769 0.459045712510139 2559 2832352 SGTC_630 4356-0227 183 µM -0.10351778839905 0.474841544043518 no 1770 0.458776016118065 2596 779312 SGTC_3224 9130643 49.47 µM -0.104766958354672 0.474355561440377 no 1771 0.458280364568035 2703 17644395 SGTC_395 anisomycin 6.25 µM -0.104858869531904 0.474319805407832 no 1772 0.458243898169854 2631 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1365 1672-3266 55.4 µM -0.10513378490665 0.474212856832112 no 1773 0.45813482568374 2610 6415873 SGTC_1351 1496-0003 46.5 µM -0.106429999642103 0.473708623842752 no 1774 0.457620595986549 2667 3891978 SGTC_250 brefeldin a 552.239 µM -0.106480248952379 0.473689077492348 no 1775 0.457600662681747 2581 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2687 chenodiol 100 µM -0.106908474602122 0.473522505669355 no 1776 0.457430794982983 2658 5702181 A cholesterol synthesis inhibitor. SGTC_659 k018-0002 107 µM -0.107885191159728 0.473142598439546 no 1777 0.457043382147593 2632 6797879 YHR007C ERG11 SGTC_1294 1000-1494 117 µM -0.10805629932842 0.473076046087836 no 1778 0.456975516597281 2601 712797 YDL207W GLE1 SGTC_561 1550-0330 72.9 µM -0.108630366543949 0.472852768717505 no 1779 0.456747837127848 2622 6812934 SGTC_3131 9127911 49.47 µM -0.109150147185909 0.472650612891461 no 1780 0.456541700376129 2805 45595681 SGTC_2167 5876490 200 µM -0.109899113023068 0.472359333553491 no 1781 0.456244692994456 2851 686534 SGTC_268 camptothecin 39.6153 µM -0.110498283368657 0.472126321622141 no 1782 0.4560071056038 2594 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_111 0083-0039 52.457 µM -0.110610453257831 0.47208270082389 no 1783 0.455962628927587 2581 759313 SGTC_19 0279-0214 38.434 µM -0.110932263235045 0.471957556727435 no 1784 0.455835030563001 2605 3566274 YBR002C RER2 SGTC_1627 st003713 25.6 µM -0.111349004464328 0.471795500284809 no 1785 0.455669798518658 2681 16195070 YER133W GLC7 SGTC_1559 coumarin 343 70.1 µM -0.111547439400581 0.471718337349174 no 1786 0.455591124546267 2703 108770 A hepatotoxic, DNA x-linker. SGTC_1738 st035555 74 µM -0.111921904055148 0.471572726811652 no 1787 0.455442664397943 2693 5331140 SGTC_873 0591-4978 488 µM -0.112423993331756 0.471377495421169 no 1788 0.455243615996807 2782 3305145 SGTC_2481 5478948 45.16 µM -0.113086424660689 0.471119927478752 no 1789 0.4549810187498 2723 77792 SGTC_802 4112-3352 742 µM -0.113217385561754 0.471069008412531 no 1790 0.454929106302034 2753 704594 SGTC_2634 4'-methoxyflavone 100 µM -0.113313164984909 0.471031768598651 no 1791 0.454891140157571 2662 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3315 9136395 68.55 µM -0.113368705340163 0.471010174175621 no 1792 0.45486912462432 2612 16876844 SGTC_763 3453-1109 128 µM -0.113638544301346 0.470905260384336 no 1793 0.454762165658021 2596 1560353 SGTC_2206 7254556 146.969 µM -0.113850602417153 0.470822813288682 no 1794 0.45467811220691 2656 4398905 SGTC_3175 9106517 49.47 µM -0.114077806860954 0.470734478767127 no 1795 0.454588057459464 2684 41468073 SGTC_960 1222-0186 7.7 µM -0.114823623319998 0.470444523896159 no 1796 0.454292462097913 2724 3126296 SGTC_566 0958-0068 16.5 µM -0.116496406622523 0.469794244610029 no 1797 0.453629566904387 2710 6815365 SGTC_84 0443-0269 128.823 µM -0.116830103549816 0.469664532548439 no 1798 0.453497343958428 2608 6150058 SGTC_262 fenpropimorph 62.5 µM -0.116891001605593 0.469640861079098 no 1799 0.453473214473791 2615 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3 0833-0587 95.581 µM -0.117503768022538 0.469402680783394 no 1800 0.453230429140176 2591 5382644 SGTC_1624 st003710 6.25 µM -0.118800636574653 0.468898628443235 no 1801 0.452716652171716 2693 24207033 SGTC_1525 8-methoxypsoralen 92.5 µM -0.118936776762646 0.468845717877182 no 1802 0.452662722451026 2664 4114 Related to psoralen; DNA damaging agent. SGTC_1971 st069429 63.5 µM -0.120292271332345 0.468318938243191 no 1803 0.452125813119874 2671 1246522 YGL099W LSG1 SGTC_2591 skatole 100 µM -0.121610704398163 0.467806614854609 no 1804 0.451603667766782 2721 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2841 9004761 38.96 µM -0.123032192919222 0.467254305413696 no 1805 0.451040802677423 2641 2991039 SGTC_1488 4013-0813 75.9 µM -0.124815722566434 0.466561416713675 no 1806 0.45033471996266 2623 2910057 SGTC_604 1000-0114 314 µM -0.125112664214119 0.466446066759098 no 1807 0.45021717874209 2698 1572745 SGTC_1744 st037937 38.9 µM -0.127022046728474 0.46570441575803 no 1808 0.449461474559977 2758 1016152 SGTC_2395 5646831 180.19 µM -0.127239013930737 0.465620147862474 no 1809 0.449375613828733 2753 6808628 SGTC_2078 5212016 200 µM -0.127629432287071 0.465468517155301 no 1810 0.449221119004962 2597 1899708 SGTC_2420 aureobasidin a 50 nM -0.127718296423419 0.465434004795752 no 1811 0.449185955111434 2926 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1547 harmine 94.2 µM -0.128498074465419 0.46513117186611 no 1812 0.448877410973468 2656 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_411 enrofloxacin 100 µM -0.128916029015506 0.464968864233879 no 1813 0.448712046593612 2758 71188 A bacterial gyrase inhibitor. SGTC_200 k038-0079 37.545 µM -0.129112237927432 0.464892670866909 no 1814 0.448634419298175 2677 3436683 SGTC_421 streptovitacin 30 mM -0.130391335982187 0.464395993259624 no 1815 0.448128410477917 2830 91467 include heat shock SGTC_377 3970-0964 33.1 µM -0.130499464652449 0.464354009105177 no 1816 0.448085638833287 2630 16481235 SGTC_470 aa-861 153 µM -0.130990097080752 0.464163511546143 no 1817 0.447891570644289 2657 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_382 3229-0966 23.2 µM -0.13112905024661 0.464109561774541 no 1818 0.447836610399593 2774 5722370 SGTC_584 0986-0246 15.4 µM -0.132488190830712 0.463581898604104 no 1819 0.447299081518692 2636 53315 YDR232W HEM1 SGTC_2128 5255449 168.493 µM -0.132942488631471 0.463405539463451 no 1820 0.447119432022448 2666 736008 SGTC_2960 9079389 5.97 µM -0.133927926124401 0.463023015800024 no 1821 0.446729783679508 2721 16457355 SGTC_614 0462-0418 107 µM -0.134127297705929 0.462945628586889 no 1822 0.446650957111914 2661 5188303 SGTC_2126 5251174 33.877 µM -0.134448049942837 0.462821129726249 no 1823 0.446524144075142 2718 790722 SGTC_499 genistein 192 µM -0.135122327200032 0.462559423252716 no 1824 0.44625757875646 2693 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2437 5741531 144.16 µM -0.136060892134529 0.462195166104017 no 1825 0.445886571755941 2774 2262990 SGTC_907 3448-6986 75.5 µM -0.136964055737929 0.461844678144729 no 1826 0.44552960333529 2749 590582 SGTC_1182 1222-0449 220 µM -0.137815199681244 0.461514404409649 no 1827 0.445193235690526 2715 658318 SGTC_1304 1165-0502 251 µM -0.137847200856741 0.461501987346199 no 1828 0.445180589761044 2684 767425 SGTC_201 4262-0159 12.803 µM -0.138950762112794 0.461073807677982 no 1829 0.444744528817288 2743 1341029 SGTC_2760 etidronate 98.04 µM -0.139024334187933 0.461045263451702 no 1830 0.444715459935805 2694 3305 A chelator and antioxidant. SGTC_1923 st058458 19.1 µM -0.13960335775268 0.460820623010779 no 1831 0.444486693750966 2875 3534982 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.140431397666724 0.460499394870949 no 1832 0.444159575946493 2619 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1018 4259-0013 28.1 µM -0.140842326408348 0.460339989558064 no 1833 0.443997252339326 2801 6801262 SGTC_285 1486-1325 46 µM -0.141102846818347 0.460238933152586 no 1834 0.44389434735951 2743 22310230 SGTC_286 k060-0067 22.9 µM -0.141588453018454 0.460050572364149 no 1835 0.443702544097743 2679 5985051 SGTC_688 0527-0193 473 µM -0.142222313399493 0.45980471906204 no 1836 0.443452203697549 2716 4007154 SGTC_153 4077-0274 519.67 µM -0.142348044140227 0.45975595412451 no 1837 0.443402549567407 2690 3121976 SGTC_3333 9141820 12.094 µM -0.142488365972843 0.459701530715593 no 1838 0.44334713410929 2708 1939433 SGTC_2919 7978188 46.38 µM -0.143776952517697 0.459201791658777 no 1839 0.442838301492688 2733 2980291 SGTC_2158 5657123 3.6195 µM -0.146804839834629 0.458027772832051 no 1840 0.441643032221202 2645 2858827 SGTC_3095 9117207 49.47 µM -0.146844144714439 0.458012535327183 no 1841 0.441627519949548 2796 17015229 SGTC_1739 st037196 92.5 µM -0.147817419626228 0.457635241071522 no 1842 0.441243430744218 2756 612214 SGTC_2066 5222451 176 µM -0.148480053020177 0.457378390174595 no 1843 0.440981963422273 2662 2281147 SGTC_324 1315-0088 19.6 µM -0.148901218396136 0.457215146699914 no 1844 0.440815789896136 2744 6787421 SGTC_119 0121-0043 24.815 µM -0.150077768943224 0.456759154673804 no 1845 0.440351629568035 2658 1092378 SGTC_1107 amlodipine 47 µM -0.150151518097218 0.456730573834133 no 1846 0.440322537551596 2715 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1092 toremifene 6.32 µM -0.150767906035386 0.45649170684657 no 1847 0.44007940204605 2659 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_608 k048-0125 159 µM -0.151473066312905 0.456218457463744 no 1848 0.439801277820925 2747 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_535 2293-4129 48.2 µM -0.151883338360968 0.456059486694862 no 1849 0.439639474942751 2798 396118 YIL048W NEO1 SGTC_2496 diffractaic acid 79.83 µM -0.152303667587976 0.455896626300386 no 1850 0.439473716175712 2914 94870 An apoptosis inducer which activates caspases. SGTC_1006 4099-6547 255 µM -0.152360154683685 0.455874740423931 no 1851 0.439451441037489 2772 3146833 SGTC_1396 3511-0007 98.6 µM -0.152952792135356 0.455645131638773 no 1852 0.439217751777261 2790 X1396 SGTC_1569 carminic acid 40.6 µM -0.153300845148986 0.455510290446593 no 1853 0.439080517110472 2753 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1561 5-methoxyflavone 52.9 µM -0.153397763475637 0.455472743679502 no 1854 0.439042304251075 2654 94525 SGTC_3345 9148410 3.559 µM -0.153447139662498 0.455453615188194 no 1855 0.439022836476688 2756 4903596 SGTC_71 0417-1750 47.813 µM -0.153469858866917 0.455444813731073 no 1856 0.43901387892189 2823 6811472 SGTC_160 3453-0671 289.699 µM -0.153472395783259 0.455443830926871 no 1857 0.439012878687784 2703 5322268 SGTC_3250 9135583 49.47 µM -0.153682536648509 0.455362423070132 no 1858 0.438930027462025 2821 7699353 SGTC_446 go6976 132 µM -0.154878967245348 0.454898965739872 no 1859 0.438458367628595 2789 3501 A protein kinase C inhibitor. SGTC_1882 5615643 20 µM -0.156100759260142 0.4544257475942 no 1860 0.437976799948695 2653 2253075 SGTC_2772 vinpocetine 57.06 µM -0.15860539516339 0.453455867930678 no 1861 0.436989888940552 2843 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3289 9119912 71.43 µM -0.158850957532425 0.453360792729108 no 1862 0.436893150087499 2801 17014829 SGTC_2666 tannic acid 100 µM -0.158885104573188 0.453347572117012 no 1863 0.436879698221004 2750 16134267 A thiamine antagonist. SGTC_269 exalamide 29 µM -0.159195460707157 0.453227414792725 no 1864 0.436757440043902 2722 3316 A derivative of salicylamide. SGTC_2179 6298986 200 µM -0.15942371620492 0.453139046241476 no 1865 0.436667527514881 2788 738374 SGTC_3264 9137442 49.47 µM -0.160446988542334 0.452742917469318 no 1866 0.436264488765023 2909 17015726 SGTC_1560 lithocholic acid 53.1 µM -0.160955638900394 0.452546026422858 no 1867 0.436064170012322 2683 9903 A bile acid which acts as a detergent. SGTC_991 3996-0057 64.7 µM -0.161609118523245 0.452293091236461 no 1868 0.435806838084981 2783 715343 SGTC_1455 4262-0120 131 µM -0.161775381701217 0.452228740658166 no 1869 0.435741370101836 2877 1529587 SGTC_590 k048-0076 22.4 µM -0.16308442270788 0.451722132783156 no 1870 0.435225982236979 2800 6832814 SGTC_2117 5521686 200 µM -0.163154369940593 0.451695064928024 no 1871 0.435198446115881 2695 803312 SGTC_58 0957-0393 9 µM -0.163635685037402 0.451508813943883 no 1872 0.435008975370921 2698 6997992 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.164016576590766 0.451361430687635 no 1873 0.434859047149139 2774 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2779 methotrexate 400 µM -0.165266169621361 0.450877956806739 no 1874 0.434367242681309 2701 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1606 st000094 49.2 µM -0.165295867195111 0.450866467548516 no 1875 0.434355555788866 2690 1242210 SGTC_3214 9129694 49.47 µM -0.165499877888641 0.450787541960314 no 1876 0.434275272968998 2789 17158655 SGTC_1978 st071761 42 µM -0.165757388115993 0.45068792179356 no 1877 0.434173940743584 2721 5147680 SGTC_254 nsc-64875 3.808 µM -0.166378783333956 0.450447542222596 no 1878 0.43392943484152 2845 56993 SGTC_2694 st077685 81.9 µM -0.166697545372237 0.450324239853567 no 1879 0.433804018511207 2690 2838096 SGTC_3253 9135987 49.47 µM -0.167039795489309 0.450191857249557 no 1880 0.433669368259083 2828 4182430 SGTC_687 k029-0044 34.9 µM -0.167681848976756 0.449943525436771 no 1881 0.433416788205669 2818 5829338 SGTC_1053 3366-3204 134 µM -0.168279289478965 0.449712466523083 no 1882 0.433181783058329 2744 3632071 YPR165W RHO1 SGTC_1381 2324-0066 62.1 µM -0.168415639349113 0.449659735871378 no 1883 0.433128152705678 2819 10885928 SGTC_2421 5690543 90.72 µM -0.170172124539417 0.448980529305626 no 1884 0.432437386673739 2795 3397993 SGTC_2676 harmalol 100 µM -0.170278611038742 0.448939357354175 no 1885 0.432395515762697 2725 5459187 A monoamine oxidase inhibitor SGTC_2460 5552655 174.22 µM -0.170872403756822 0.448709783367947 no 1886 0.43216204805992 2826 5401989 SGTC_2069 5228469 200 µM -0.173029101837292 0.447876099070471 no 1887 0.431314276330413 2842 2835210 SGTC_1645 Cervolide 78 µM -0.173434717810506 0.447719331442342 no 1888 0.431154868857615 2798 23173 A fragrance. SGTC_191 3914-0123 66.505 µM -0.174703733789979 0.447228918832185 no 1889 0.430656216879463 2726 3144412 SGTC_2187 6125751 200 µM -0.175268613707835 0.447010646274493 no 1890 0.430434286317899 2758 874498 SGTC_2836 9010338 19.48 µM -0.175342583184438 0.446982065268514 no 1891 0.430405226744736 2743 2994051 SGTC_2171 5739187 198.077 µM -0.176029788149191 0.446716549882051 no 1892 0.430135270139411 2677 2262761 SGTC_2686 alizarin 95.37 µM -0.176645698596861 0.446478600850868 no 1893 0.429893348098946 2783 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_288 1315-0019 35.1 µM -0.178066506572493 0.445929763715378 no 1894 0.429335372753582 2773 6811474 SGTC_1836 st055642 81 µM -0.178177911090194 0.445886734161555 no 1895 0.429291628266899 2738 8571 SGTC_2282 7944268 200 µM -0.178885279379057 0.445613530852923 no 1896 0.429013890848445 2871 2970414 SGTC_1958 st076513 41.9 µM -0.179326040134617 0.44544331108572 no 1897 0.428840850591917 2710 732122 YGL099W LSG1 SGTC_2557 derrustone 83.84 µM -0.179523876472568 0.445366910874421 no 1898 0.428763185575232 2836 629853 An antioxidant. SGTC_1660 st012960 28.1 µM -0.180016557291654 0.445176656781874 no 1899 0.428569784850535 2804 24207266 SGTC_2470 5664817 21.68 µM -0.180332933105136 0.445054491452268 no 1900 0.428445601291791 2710 2859561 SGTC_3010 9080089 71.4286 µM -0.180553514841828 0.444969319125975 no 1901 0.428359022931737 2831 17027233 SGTC_1806 st050005 60.3 µM -0.180714920660147 0.444906997765034 no 1902 0.428295673311651 2722 5194765 SGTC_2251 lansoprazole 556 µM -0.180864538850069 0.444849229011603 no 1903 0.428236951827958 2723 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3106 9121286 49.47 µM -0.182423751775814 0.444247274639032 no 1904 0.427625093656775 2936 15943471 SGTC_458 nppb 133 µM -0.182477757096577 0.444226427480495 no 1905 0.427603904281239 2878 4549 A chloride channel blocker. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.183445060508464 0.443853054765097 no 1906 0.427224411261647 2861 5024745 SGTC_537 1334-0398 209 µM -0.184931800200907 0.443279280352298 no 1907 0.426641264106618 2838 5846986 SGTC_2525 harmine 47.85 µM -0.185087542699141 0.44321918182796 no 1908 0.426580186141325 2814 5280953 A monoamine oxidase inhibitor SGTC_3054 9094397 49.47 µM -0.185201413193152 0.443175241862926 no 1909 0.426535530349608 2763 2598354 SGTC_2254 7938975 95.19 µM -0.186187934567112 0.44279459560583 no 1910 0.426148692673533 2931 2969277 SGTC_959 1222-0044 107 µM -0.186989377496869 0.442485400151798 no 1911 0.425834480791182 2801 6083612 SGTC_570 0987-0065 62.6 µM -0.187871108222288 0.442145270265395 no 1912 0.425488845863062 2700 3104428 SGTC_676 falcarinol 140 µM -0.18941124544889 0.441551260835613 no 1913 0.424885255703227 2870 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_25 0118-0223 35.662 µM -0.190609485261502 0.441089207304283 no 1914 0.424415779141431 2862 5333628 SGTC_134 0269-0018 6.916 µM -0.190643349357907 0.441076150124279 no 1915 0.424402512567927 2833 4378915 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.190956874014374 0.440955265611001 no 1916 0.424279690448203 2752 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_338 4055-0136 114 µM -0.192358666492501 0.440414849242024 no 1917 0.423730633550105 2743 2900563 SGTC_1122 capsaicin 818.572 nM -0.192622342472571 0.440313209749298 no 1918 0.423627372921403 2884 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2927 9011802 47.9 µM -0.193068450943004 0.44014125674712 no 1919 0.423452680136739 2869 43912568 SGTC_1262 0737-0114 49.6 µM -0.193379594021712 0.440021332984916 no 1920 0.42333084770771 2822 765919 SGTC_373 0844-0104 25.9 µM -0.193557994885258 0.43995257448708 no 1921 0.423260995657356 2862 5375804 SGTC_2221 6807166 181.081 µM -0.193803962959271 0.43985777749414 no 1922 0.423164691927408 2800 674925 SGTC_1530 rhein 70.4 µM -0.194161007952603 0.439720177187869 no 1923 0.423024906488898 2731 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_697 0508-1955 564 µM -0.194221143315405 0.439697002549273 no 1924 0.423001364056013 2854 6243113 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.19575477017062 0.439106051832838 no 1925 0.422401056616191 2724 2333 A French combination drug. SGTC_1539 benzyladenosine 56 µM -0.196417548596517 0.438850706081044 no 1926 0.422141680993084 2751 92208 A nucleotide analog. SGTC_2804 7954240 19.48 µM -0.19715328025046 0.438567283764738 no 1927 0.421853794970446 2915 828705 SGTC_2352 9027995 87.8 µM -0.197677879725723 0.438365214097447 no 1928 0.421648548804685 2812 2997347 SGTC_885 0865-0106 16.8 µM -0.197753120955088 0.43833623335997 no 1929 0.42161911290225 2756 2793380 SGTC_3208 9114115 49.47 µM -0.198306141491034 0.438123236059246 no 1930 0.42140277344758 2830 650895 SGTC_714 4296-0578 26.1 µM -0.199010711368603 0.43785189510767 no 1931 0.421127182862886 2781 1589775 SGTC_34 0469-0683 81.75 µM -0.199596162433151 0.437626450907892 no 1932 0.420898214664156 2844 3690923 SGTC_3137 9097352 49.47 µM -0.199694759677365 0.437588485289432 no 1933 0.4208596562006 3066 44120435 SGTC_2629 bisabolol 100 µM -0.202059709020117 0.436678016535004 no 1934 0.419935022839408 2924 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1700 st030840 7.9285 µM -0.202301593445671 0.436584913611127 no 1935 0.419840477170341 2868 5499307 SGTC_1417 3966-0327 90.4 µM -0.20341976171491 0.436154568941818 no 1936 0.419403477543521 2801 651118 SGTC_711 k292-0785 179 µM -0.204060776204078 0.435907898465957 no 1937 0.419153002707002 2746 4146315 SGTC_2133 5320837 200 µM -0.207503517543128 0.43458351693055 no 1938 0.417808322927189 2930 2841355 SGTC_2517 totarol 10 µM -0.20889081465186 0.434050046846837 no 1939 0.417266737417241 2849 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2056 5235370 200 µM -0.210716734028955 0.433348092513715 no 1940 0.416554157956644 2815 5511916 SGTC_141 0443-0274 32.331 µM -0.212572084780667 0.432635038939146 no 1941 0.415830373458615 2903 1627241 SGTC_650 1328-0195 38 µM -0.21272243365789 0.432577266014802 no 1942 0.415771733844375 2805 2780821 SGTC_2975 9084847 53.72 µM -0.213697772401106 0.432202518283878 no 1943 0.415391374292488 2884 27211724 SGTC_3100 9120536 49.47 µM -0.215258888262973 0.431602828485999 no 1944 0.414782740334109 2731 16421196 SGTC_42 0133-0086 60.653 µM -0.215959213133357 0.431333855582818 no 1945 0.414509770267277 2740 162923 Model of phenazepam hydroxylation. SGTC_1948 st076329 66.6 µM -0.218013770923571 0.43054494829122 no 1946 0.413709190922248 2737 24208413 SGTC_1391 3442-0225 151 µM -0.218079576027259 0.430519685068809 no 1947 0.413683555202292 2792 5227075 SGTC_1075 aripiprazole 15.2 µM -0.218887712154741 0.430209456932633 no 1948 0.413368759328693 2778 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2487 5918373 44.05 µM -0.219119696337517 0.430120410552676 no 1949 0.413278404058601 2794 2876279 SGTC_1642 st009582 77.7 µM -0.219397354133927 0.430013837176343 no 1950 0.413170265460451 2926 6739311 SGTC_2807 7945238 51.95 µM -0.219686882789756 0.429902712839262 no 1951 0.413057510568102 2914 17148797 SGTC_1420 4'-methoxyflavone 42 µM -0.219864814013247 0.429834423599399 no 1952 0.412988220065826 2828 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1619 st003326 88.7 µM -0.220084592852042 0.429750076322349 no 1953 0.412902636883788 2953 2849032 SGTC_1563 conessine 56.1 µM -0.220529955223427 0.429579163864226 no 1954 0.412729222835115 2920 441082 An anti-amoebic, histamine inhibitor. SGTC_1147 3809-1045 12.3 µM -0.221665581081251 0.429143415395296 no 1955 0.412287112932918 2799 325925 SGTC_2275 7947463 200 µM -0.222016017000042 0.429008967815901 no 1956 0.412150707352921 2773 1225414 SGTC_3065 9113888 49.47 µM -0.224931545909657 0.427890722276709 no 1957 0.41101626397777 2995 16648368 SGTC_56 0957-0365 83.25 µM -0.22499825364671 0.427865143392064 no 1958 0.410990316411819 2867 6752360 SGTC_785 1270-0111 65.3 µM -0.225222380316266 0.427779204903812 no 1959 0.41090313984911 2778 6741994 SGTC_2795 7780010 54.55 µM -0.225691846086087 0.427599205402354 no 1960 0.410720550179735 2940 953673 SGTC_1446 4239-0190 62 µM -0.226649737056399 0.427231983876387 no 1961 0.410348056981144 2820 1340085 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.226855812278395 0.427152990152962 no 1962 0.410267931468589 3225 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2814 7977482 42.97 µM -0.227811081913059 0.426786849904767 no 1963 0.409896555544063 2975 6456762 SGTC_1776 st049249 45.9 µM -0.227881096264995 0.426760016951022 no 1964 0.409869339550609 2845 1822314 SGTC_142 0335-0849 62.6745 µM -0.2290364395404 0.42631728144406 no 1965 0.409420297069175 2830 3889043 YPR107C YTH1 SGTC_1222 0366-0074 1.18 µM -0.231112068627699 0.425522119649951 no 1966 0.408613869748208 2954 286520 SGTC_3173 9105693 49.47 µM -0.231355175187446 0.425429006647182 no 1967 0.408519442768415 2973 17096658 SGTC_1073 triclabendazole 3.09 µM -0.233611440470126 0.424565026518136 no 1968 0.407643322637325 2889 50248 An antihelmetic and likely tubulin inhibitor. SGTC_116 0155-0182 31.788 µM -0.233993383359056 0.424418806824252 no 1969 0.407495057703161 2835 771486 SGTC_1688 st021091 57.6 µM -0.235012438147001 0.424028731702509 no 1970 0.407099539656369 2904 3656366 SGTC_2277 7947813 106.88 µM -0.236324626638314 0.423526560135135 no 1971 0.406590389387444 3057 1246798 SGTC_1205 4161-2785 76 µM -0.236452746696949 0.423477535519997 no 1972 0.406540685187127 2955 3498106 SGTC_1054 3429-0080 167 µM -0.236683841584413 0.423389111004649 no 1973 0.406451035690943 3003 1162877 SGTC_1386 3228-0095 33.8 µM -0.236766660422317 0.423357422728435 no 1974 0.406418908665478 2956 870181 SGTC_1920 st075728 45.7 µM -0.238284800604369 0.422776637541266 no 1975 0.405830104618834 3034 3400306 SGTC_2651 TUB2.036 5 µM -0.239378659249246 0.422358270973771 no 1976 0.405405988243639 2941 15992207 YFL037W TUB2 SGTC_2299 7976368 114.88 µM -0.241321160399816 0.421615541455383 no 1977 0.40465310590889 2975 2979718 SGTC_2645 abamectin 100 µM -0.241971947260506 0.421366770552472 no 1978 0.404400950119754 2957 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_833 3852-0053 558 µM -0.241974114404403 0.421365942188701 no 1979 0.404400110498085 2994 3123681 SGTC_1661 st013063 9.66 µM -0.243457096511693 0.420799172539808 no 1980 0.403825658680783 2852 721395 SGTC_1342 1486-1464 234 µM -0.245676257726681 0.419951355096079 no 1981 0.402966426294584 2835 3253938 SGTC_3021 9087658 49.47 µM -0.245821352958644 0.419895935210557 no 1982 0.402910263443404 2875 25237042 SGTC_180 1486-1293 102.781 µM -0.247046515300744 0.4194280414623 no 1983 0.402436112743019 2937 4140536 SGTC_1218 1348-1416 30.7 µM -0.247243483625552 0.419352829186664 no 1984 0.402359897302935 2822 6787668 SGTC_2274 7947094 46.08 µM -0.24808864469916 0.419030138250622 no 1985 0.40203291062558 2836 2971028 SGTC_678 1218-2179 85.9 µM -0.248103329068182 0.419024532092653 no 1986 0.402027229955181 2844 6820081 YOR116C RPO31 SGTC_1435 4092-0789 56.7 µM -0.248162023218137 0.41900212416592 no 1987 0.402004524241065 2938 2248285 SGTC_2989 9073649 71.4286 µM -0.248281713998346 0.418956430098607 no 1988 0.401958223127881 2833 21367202 SGTC_1993 st073995 70.8 µM -0.24916638267019 0.418618726165169 no 1989 0.401616041112945 2876 3098394 SGTC_758 0868-0029 16 µM -0.249281126351957 0.418574929530535 no 1990 0.401571664792097 2960 762687 SGTC_657 3534-0529 86.7 µM -0.249446757067704 0.418511711551395 no 1991 0.401507610503423 3006 1049549 SGTC_172 1112-0046 2.638 µM -0.252889547657179 0.417198145158791 no 1992 0.400176783382856 2890 2802135 YIL048W NEO1 SGTC_1019 4262-0212 3.4 µM -0.25294259505888 0.417177912578781 no 1993 0.400156286679062 2932 4677213 SGTC_2553 4-methylesculetin 85.09 µM -0.253414755644124 0.41699783752207 no 1994 0.399973863182544 2895 5319502 SGTC_2636 apigenin dimethyl ether 100 µM -0.254426778907504 0.416611925535632 no 1995 0.399582932451452 2994 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1093 fluphenazine 7.97 µM -0.254985405227609 0.416398940526265 no 1996 0.399367185839049 2860 6602611 An atypical antipsychotic. SGTC_1105 epirubicin 18.1 µM -0.255149392271509 0.416336422561763 no 1997 0.399303858369009 2847 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_622 1348-1566 26.3 µM -0.25549172286047 0.416205920222933 no 1998 0.39917166786779 2949 7340407 SGTC_997 3996-0078 137 µM -0.2561514688662 0.41595443970797 no 1999 0.398916940449247 2922 735687 SGTC_2306 7482397 179.52 µM -0.257986612078199 0.415255105185821 no 2000 0.398208619795392 3027 891448 SGTC_2435 5706476 10.6 µM -0.264194140578685 0.412891548413008 no 2001 0.395815162930139 3031 5725375 SGTC_3307 9126885 69.2785 µM -0.264517586029701 0.412768480183081 no 2002 0.395690557781112 2873 24824909 SGTC_3337 9144342 33.5465 µM -0.266430596902433 0.412040771600657 no 2003 0.394953801806158 2960 17682949 SGTC_3129 9127257 49.47 µM -0.267000781533069 0.411823931968572 no 2004 0.394734279676362 2900 837894 SGTC_1915 st067105 30.6 µM -0.268422145625016 0.411283508496804 no 2005 0.394187197516272 2847 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2849 9019321 12.99 µM -0.268618999686655 0.411208674941325 no 2006 0.39411144493904 3006 16489627 SGTC_1195 1502-0147 41.1 µM -0.269997198772338 0.410684846805849 no 2007 0.393581204330056 2886 817940 SGTC_2028 5153890 36.43 µM -0.270349846088503 0.410550837596559 no 2008 0.393445560432822 2891 2830968 YPR165W RHO1 SGTC_735 3076-0345 636 µM -0.270487015337563 0.410498714845782 no 2009 0.393392802509819 3043 2888990 SGTC_401 neomycin 50 µM -0.270495954599895 0.410495318082868 no 2010 0.393389364366071 2930 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1725 st036284 20.55 µM -0.271501674048786 0.410113205256023 no 2011 0.393002606169385 3118 707914 SGTC_2183 6420625 130.508 µM -0.272687955493618 0.409662599455771 no 2012 0.39254654703776 2871 2897619 SGTC_633 0437-0093 97.7 µM -0.276331456597866 0.408279373749155 no 2013 0.391146748636444 2896 2831118 SGTC_2974 9094440 9.66 µM -0.277946061271698 0.40766676631578 no 2014 0.390526882316157 3084 25236134 SGTC_1722 st034304 3.6505 µM -0.278138382191994 0.407593811626103 no 2015 0.390453066489393 2901 4036148 YLR033W RSC58 SGTC_1514 1189-1591 158 µM -0.278477053626853 0.407465348373835 no 2016 0.390323088608612 3096 767698 YMR146C TIF34 SGTC_265 mycophenolic acid 32.932 µM -0.279066935182244 0.407241621050351 no 2017 0.390096728687411 3146 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.279092991580355 0.407231739207393 no 2018 0.390086730718127 2956 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1456 k015-0012 13 µM -0.279403245812596 0.40711408037667 no 2019 0.38996769021798 3073 2989616 SGTC_1797 st048695 56.8 µM -0.280485931627596 0.406703555257331 no 2020 0.38955235870237 3036 592262 YIL048W NEO1 SGTC_2092 5303694 80.6725 µM -0.283732086349166 0.405473317471638 no 2021 0.388307851724897 2924 1963699 SGTC_1231 0242-0792 125 µM -0.285725834312385 0.404718182491138 no 2022 0.387544058145121 2893 3707635 SGTC_3252 9135871 49.47 µM -0.285795048405465 0.404691973906216 no 2023 0.387517550413472 3052 17682838 SGTC_1031 k035-0009 16 µM -0.286390895568084 0.404466368319018 no 2024 0.387289373547878 3095 5180959 SGTC_329 k048-0121 21.3 µM -0.286916717552082 0.404267302740991 no 2025 0.387088044831762 2987 6832902 SGTC_3309 9129340 25.759 µM -0.28831378605934 0.403738521367107 no 2026 0.386553277626121 2948 17158987 SGTC_2129 girgensonine 121.053 µM -0.288571416451904 0.403641029113334 no 2027 0.386454685848391 2984 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2791 5663188 71.43 µM -0.290825944521817 0.402788128768122 no 2028 0.385592220856953 3087 54690634 SGTC_1907 st060210 83.7 µM -0.291161829121666 0.402661101258959 no 2029 0.38546377719375 3079 688793 SGTC_1221 2958-7315 257 µM -0.291213810815685 0.402641443326357 no 2030 0.385443900300538 2993 4562705 SGTC_1106 tegaserod maleate 11.7 µM -0.292248501558285 0.402250205297558 no 2031 0.385048315272085 2964 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2868 9035608 32.47 µM -0.292643453027676 0.402100891752743 no 2032 0.384897348157169 2878 6462614 SGTC_2173 5763948 167 µM -0.29271046670662 0.40207555828501 no 2033 0.384871734432515 2884 2867177 SGTC_2384 9036245 200 µM -0.29272616460139 0.40206962400216 no 2034 0.384865734512893 2971 6462766 SGTC_2768 sulfasalazine 50.2 µM -0.293008897298662 0.401962746288181 no 2035 0.384757675479088 3043 5384001 An antioxidant and salicylic acid derivative. SGTC_1302 1159-0335 255 µM -0.294525336976373 0.40138963188015 no 2036 0.384178252717847 2931 649284 SGTC_2311 7694451 200 µM -0.296025955816895 0.400822705459584 no 2037 0.383605129696948 2981 2163142 SGTC_126 0417-1624 672.48 µM -0.297012517275303 0.400450101082315 no 2038 0.383228476363699 3023 41912 YDL195W SEC31 SGTC_2472 5377652 49.4 µM -0.298513085039599 0.399883540643919 no 2039 0.382655795351813 2980 1610903 SGTC_1891 st059073 26.2 µM -0.298727419460373 0.399802632841428 no 2040 0.382574017050224 3123 688754 SGTC_1987 st072290 61.9 µM -0.299674184639722 0.399445295699878 no 2041 0.382212845890517 2988 54697379 SGTC_2423 st077119 87.2 µM -0.299947186295607 0.399342272442852 no 2042 0.382108720473954 2922 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_223 busulfan 5 mM -0.302639724742482 0.398326559637302 no 2043 0.381082218656337 3024 2478 A DNA alkylator. SGTC_3056 9094900 49.47 µM -0.303027447922626 0.398180354429353 no 2044 0.380934472003417 2986 25236784 SGTC_2350 9023895 38.85 µM -0.30489005173515 0.397478191146491 no 2045 0.38022494641472 3096 2997209 SGTC_2730 imipramine 71.33 µM -0.306045031761615 0.39704295410874 no 2046 0.379785179636639 2955 3696 A tricyclic antidepressant. SGTC_1683 st010134 710 nM -0.307465441937857 0.396507869490604 no 2047 0.379244561615695 2932 3818134 SGTC_2188 6126565 140.678 µM -0.307656733596801 0.396435822619713 no 2048 0.379171772689743 3051 874518 SGTC_300 r073-0011 5.04 µM -0.309185227162767 0.395860267758457 no 2049 0.378590315377181 3042 2735780 SGTC_1680 diphenhydramine 100 µM -0.30971234551436 0.395661833705666 no 2050 0.37838985686971 2989 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_707 0865-0008 204 µM -0.3098117614537 0.395624411539009 no 2051 0.378352053522173 2966 723043 SGTC_2186 6124449 200 µM -0.310187602843124 0.395482945950155 no 2052 0.378209148707387 3099 3834182 YLR033W RSC58 SGTC_1729 st035615 45.989 µM -0.310559861099683 0.395342842615881 no 2053 0.378067622715807 3054 17385451 SGTC_881 0833-0569 170 µM -0.310576012354177 0.395336764226371 no 2054 0.378061482665291 2963 5418700 SGTC_2707 st078556 66.6 µM -0.311231756995626 0.395090001736094 no 2055 0.377812221230413 3025 17250899 SGTC_828 2074-0507 139 µM -0.313552905998325 0.394216871544574 no 2056 0.376930316194067 3104 X828 SGTC_2560 caryophyllene 100 µM -0.314459150915885 0.393876119781834 no 2057 0.376586168419989 2929 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_81 0411-0046 9.971 µM -0.314621436095045 0.393815108465176 no 2058 0.376524550741336 2973 12925265 SGTC_22 0964-0034 14.468 µM -0.314982116793368 0.393679519439707 no 2059 0.376387616001956 2998 138402 SGTC_1802 st050112 57.9 µM -0.316966250360485 0.392933864198763 no 2060 0.375634605567781 2946 4662563 SGTC_746 1095-0025 46.6 µM -0.317006688741027 0.392918671165811 no 2061 0.375619263469014 3147 6749286 SGTC_483 fpl-64176 144 µM -0.317450726764364 0.392751853154601 no 2062 0.375450810831074 2971 3423 SGTC_1005 4092-0690 4.4 µM -0.319134583944231 0.392119434065566 no 2063 0.374812229762559 3019 1529343 SGTC_168 3970-0862 530.542 µM -0.319935094118453 0.391818880152527 no 2064 0.374508766842581 3044 3135186 SGTC_988 1497-1057 103 µM -0.319990210426544 0.391798188944781 no 2065 0.37448787582967 3026 3533044 SGTC_1267 0828-0272 9.49 µM -0.321037040502285 0.391405256741267 no 2066 0.374091160553403 3108 745334 SGTC_1912 st060209 90.8 µM -0.322258607951033 0.390946876199256 no 2067 0.373628393937916 3035 688787 SGTC_203 k066-0004 30.888 µM -0.322613078854857 0.390813892985917 no 2068 0.37349414372874 3047 6795412 SGTC_3018 9082602 49.47 µM -0.323623958081876 0.390434721968917 no 2069 0.373111373687966 2988 17332089 SGTC_1763 st044482 94.5 µM -0.323973725613214 0.39030355179411 no 2070 0.37297896313376 3111 88505 SGTC_548 1436-0017 110 µM -0.325894197522112 0.389583557342285 no 2071 0.372252202980322 3127 9677137 SGTC_2661 dactinomycin 12.96 µM -0.326795653597378 0.389245727466464 no 2072 0.371911223517641 3012 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2737 bleomycin 30.5 nM -0.326902187346187 0.389205808380859 no 2073 0.371870933320867 2996 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2540 epiandrosterone 100 µM -0.326995225068162 0.389170947325753 no 2074 0.371835748359347 2999 441302 A steroid. SGTC_3004 9076122 71.4286 µM -0.327561276880957 0.388958868037135 no 2075 0.371621702231143 3133 44782551 SGTC_178 4092-0806 87.505 µM -0.327900051760333 0.388831957075014 no 2076 0.371493617298198 3062 2169044 SGTC_2376 9072922 81.32 µM -0.329317271893455 0.388301170521991 no 2077 0.370957945238456 3105 17087968 SGTC_330 1488-0319 80.1 µM -0.329950341386787 0.388064136520585 no 2078 0.370718742270729 3055 6846614 SGTC_805 3852-0218 479 µM -0.332024949483632 0.387287653998317 no 2079 0.369935209848489 2965 6615355 SGTC_2476 5806916 10.51 µM -0.333361029562104 0.386787825508538 no 2080 0.369430888137804 2969 2870194 SGTC_3062 9077494 49.47 µM -0.334780996738146 0.386256820571578 no 2081 0.368895148278515 3114 16459633 SGTC_1671 st016596 74.5 µM -0.335159405110974 0.386115348470952 no 2082 0.368752421393711 3034 2829167 SGTC_1859 st055998 20 µM -0.337395049552414 0.385279837965272 no 2083 0.367909557996311 3192 676301 SGTC_3050 9093513 49.47 µM -0.337690339619916 0.385169521146731 no 2084 0.36779827771438 3005 25236664 SGTC_2201 6605497 169.863 µM -0.338408175557022 0.384901385040036 no 2085 0.367527806996503 3031 670741 SGTC_2318 6029776 164 µM -0.338853359789781 0.38473512124776 no 2086 0.367360100691713 3192 818325 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.338976724686757 0.384689051677138 no 2087 0.367313632112471 3055 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2164 5685496 200 µM -0.33931131055139 0.384564111632448 no 2088 0.367187611476333 3126 759046 SGTC_3178 9107506 49.47 µM -0.339501326847181 0.384493161657292 no 2089 0.367116048848742 3150 8897194 SGTC_2705 st078069 42.8 µM -0.34035778139322 0.384173419091741 no 2090 0.366793554170084 3071 1530061 SGTC_1065 prochlorperazine maleate 2.48 µM -0.342564913308495 0.383349788101293 no 2091 0.365962900838703 3049 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1811 st050069 61.5 µM -0.344248637885827 0.382721830060003 no 2092 0.3653296536277 3062 3877702 SGTC_700 3453-2283 142 µM -0.344603301196532 0.382589594888748 no 2093 0.365196311827648 3187 565664 SGTC_3117 9124945 49.47 µM -0.344780321586704 0.382523598477364 no 2094 0.365129764048847 2943 17592065 SGTC_1718 roemerine 11.9335 µM -0.345343289721435 0.382313736434949 no 2095 0.364918152842681 3146 235224 An aporphine alkaloid with mutagenic activity. SGTC_136 0097-0015 404.482 µM -0.34597655042537 0.382077712190075 no 2096 0.364680168888064 3081 4861337 SGTC_1626 st003712 1.76 µM -0.346316240918821 0.381951123312639 no 2097 0.364552532221061 3168 24207035 SGTC_3089 9117425 49.47 µM -0.346552223449199 0.381863189617429 no 2098 0.364463872037066 3072 9401657 SGTC_2111 5486399 200 µM -0.346707683384423 0.381805264224625 no 2099 0.364405468681253 3014 689674 SGTC_1736 st036774 51 µM -0.347135801778074 0.381645758181818 no 2100 0.364244648976642 3246 1272247 SGTC_229 benomyl 22.8748 µM -0.347600280279025 0.381472728014329 no 2101 0.364070197880012 3100 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_969 1313-0238 134 µM -0.348934501955175 0.380975828031915 no 2102 0.363569241164856 3007 5212874 SGTC_2507 purpurin 79.67 µM -0.351430772446596 0.380046677410678 no 2103 0.362632599863516 3005 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1520 flindersine 88 µM -0.351594701706797 0.379985684548795 no 2104 0.362571119621314 3279 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1478 0453-0656 35.7 µM -0.352072152484802 0.379808057318045 no 2105 0.362392076057381 3099 5258496 SGTC_3045 9092950 49.47 µM -0.35219109601263 0.379763810397803 no 2106 0.3623474770345 3178 44120432 SGTC_1161 k007-0610 110 µM -0.353366686738029 0.379326576113075 no 2107 0.36190677852552 3138 5843850 SGTC_1554 st069299 38.7 µM -0.354081772723269 0.379060691552369 no 2108 0.361638800809642 3099 24207999 SGTC_1362 1611-0397 101 µM -0.354101666752784 0.379053295335801 no 2109 0.361631346512556 3050 27816 SGTC_523 1934-0222 13.7 µM -0.356185124974992 0.378278951375272 no 2110 0.360850965489231 3035 1361595 SGTC_824 1304-0008 100 µM -0.356985362639802 0.377981662492858 no 2111 0.360551381835448 3042 768245 SGTC_1502 4534-4282 27.7 µM -0.358383118628587 0.377462568497924 no 2112 0.360028311597989 3074 3278949 SGTC_2462 5162487 171.77 µM -0.35907812649552 0.377204541085293 no 2113 0.359768322217916 3105 2259986 SGTC_1468 k284-1086 134 µM -0.36049591133477 0.376678346825939 no 2114 0.359238156833147 3056 15996457 SGTC_2743 auranofin 4.32 µM -0.361091045148922 0.376457538061586 no 2115 0.359015693617505 3067 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1613 st002381 52.1 µM -0.361399404571048 0.376343145293081 no 2116 0.358900446523751 3108 551167 SGTC_456 gingerol 170 µM -0.361659575684795 0.376246637493608 no 2117 0.358803219448702 3225 442793 A herb. SGTC_2185 6113692 200 µM -0.363277942898762 0.375646494784258 no 2118 0.358198634251381 3168 874150 SGTC_2148 5546263 113.568 µM -0.365535601790497 0.374809784789263 no 2119 0.357355818137248 3027 792097 SGTC_529 4076-0302 30.3 µM -0.365852672845451 0.374692322297642 no 2120 0.357237506603852 3044 5816522 SGTC_2143 5623677 140.463 µM -0.366178243798315 0.374571723021673 no 2121 0.357116037708564 3114 5375313 SGTC_1904 st060225 78 µM -0.366914211518285 0.374299148185618 no 2122 0.356841505212199 3091 66595 SGTC_3151 9099821 49.47 µM -0.368953702861626 0.373544125722954 no 2123 0.356081116829387 3163 17174189 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.369960085909404 0.373171739924738 no 2124 0.355706115236621 3079 688664 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.370964926985269 0.372800042857032 no 2125 0.355331827492587 3178 521171 SGTC_2658 polymyxin b sulfate 77.05 µM -0.371641825158383 0.372549720663333 no 2126 0.355079772017024 3072 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1379 2144-0755 36.5 µM -0.371868495367739 0.372465908286903 no 2127 0.354995381363583 3239 5392327 SGTC_1300 1094-0077 113 µM -0.372280122947459 0.372313722496594 no 2128 0.354842148182159 3056 5532636 SGTC_3195 9113082 49.47 µM -0.373787079352405 0.371756745089567 no 2129 0.354281366528058 3160 17018038 SGTC_1771 st048882 4.1505 µM -0.37410856293388 0.371637958097167 no 2130 0.354161774109385 3045 4580403 SGTC_3197 9113331 49.47 µM -0.374555843087665 0.371472710069548 no 2131 0.353995409087535 3282 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_236 1509-0011 5.31 µM -0.374594515088817 0.37145842377834 no 2132 0.353981026417125 3194 3107280 SGTC_1979 st071809 45.3 µM -0.375164512254524 0.37124787478693 no 2133 0.353769060494663 3190 4976333 SGTC_1076 itraconazole 331 nM -0.375490165172855 0.371127600437056 no 2134 0.353647979668923 3113 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1150 3909-7983 10.9 µM -0.377506083836379 0.370383335803865 no 2135 0.352898772015864 3091 23965914 SGTC_762 1165-0429 115 µM -0.378063794998495 0.370177517831584 no 2136 0.352691601557821 3185 5967793 SGTC_2950 9072895 21.46 µM -0.378443192719086 0.370037525968556 no 2137 0.352550693351637 3203 17332245 SGTC_1662 st014054 52 µM -0.378560413425782 0.369994276830098 no 2138 0.352507161704296 3100 2838777 SGTC_1510 1123-0200 71.5 µM -0.381781386136729 0.368806528573795 no 2139 0.351311763280848 3290 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_121 0557-0495 61.343 µM -0.38254324122554 0.368525773728836 no 2140 0.351029230722544 3097 3104427 SGTC_3142 9086498 49.47 µM -0.384695534688737 0.367733001400303 no 2141 0.350231501943002 3155 25236367 SGTC_272 doxorubicin 8.13 µM -0.38578318869627 0.367332590661794 no 2142 0.349828623409433 3118 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_852 0418-0143 439 µM -0.386435787685926 0.367092410990401 no 2143 0.349586974950927 3192 5369229 SGTC_2200 6600604 21.907 µM -0.386981336731474 0.366891669414587 no 2144 0.349385012375357 3080 2904777 SGTC_1614 st002383 48.6 µM -0.387676080764763 0.366636082370182 no 2145 0.349127879451229 3170 1947235 SGTC_2151 5563267 85.4165 µM -0.387708540492231 0.366624142315158 no 2146 0.349115867417368 3121 5310824 SGTC_672 1441-0018 53.7 µM -0.388621758775498 0.366288275100092 no 2147 0.348777984214831 3069 251141 SGTC_628 1636-0253 16 µM -0.38875231781599 0.366240265914319 no 2148 0.348729688240919 3150 4456143 SGTC_57 miconazole 162.5 nM -0.389898553339682 0.365818862006571 no 2149 0.348305781844723 3144 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_138 0850-0259 40.9225 µM -0.391198564388703 0.365341119702915 no 2150 0.347825234689526 3181 6813004 SGTC_2909 7941780 10.49 µM -0.391239443344861 0.365326100439695 no 2151 0.347810127802662 3244 1243215 SGTC_2076 5212012 200 µM -0.391759424579784 0.365135073105857 no 2152 0.347617988954516 3112 604802 SGTC_1848 st056003 16.4 µM -0.392067361765691 0.36502196091235 no 2153 0.347504221188557 3201 146492 SGTC_1732 st034308 51.822 µM -0.392133850850948 0.364997539530373 no 2154 0.347479658518166 2986 830119 SGTC_1511 0906-3109 28.5 µM -0.394269912151742 0.364213258006337 no 2155 0.346690887276092 3084 2882180 SGTC_609 0986-0026 86.3 µM -0.39611024850681 0.363538011121122 no 2156 0.346011849077243 3104 2848610 SGTC_1383 3049-0032 20.7 µM -0.396934017853976 0.363235895003836 no 2157 0.345708058943295 3237 712864 SGTC_1473 k844-0725 134 µM -0.397393192997459 0.363067530150183 no 2158 0.345538767167856 3147 54682906 SGTC_2016 5121758 140 µM -0.398952744023902 0.362495890339292 no 2159 0.344964012215381 3100 2795203 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.399175339674764 0.362414324806081 no 2160 0.344882006223931 3235 756377 SGTC_45 0kpi-0036 14.9 µM -0.403154977594275 0.360957126599062 no 2161 0.343417109109409 3239 2795021 SGTC_2944 9067346 25.62 µM -0.40364696771063 0.360777117359036 no 2162 0.34323617120306 3257 6473075 SGTC_3233 9132340 49.47 µM -0.403947011734705 0.360667352451104 no 2163 0.343125842439275 3114 17682950 SGTC_261 5-fluorouridine 15.376 µM -0.404028307998375 0.360637613868406 no 2164 0.343095951407042 3322 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2746 daunorubicin 9.88 µM -0.404841993787779 0.360340009968466 no 2165 0.342796829312957 3149 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3108 9121785 49.47 µM -0.405178981528101 0.360216782159977 no 2166 0.342672976822288 3174 17140271 SGTC_648 0375-0473 33.3 µM -0.405856842393297 0.359968949752359 no 2167 0.342423895082299 3122 1713139 SGTC_2196 6573537 42.6665 µM -0.407409638047897 0.359401454797736 no 2168 0.341853574675359 3241 2903087 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.408925883994969 0.358847616631674 no 2169 0.34129702651213 3182 77254 SGTC_842 0271-0008 11.1 µM -0.409133690161586 0.358771734495532 no 2170 0.341220776731698 3252 1221709 SGTC_418 lividomycin a 100 µM -0.409499233181286 0.35863826697368 no 2171 0.341086664707458 3253 72394 An antibiotic. SGTC_1154 4088-0362 150 µM -0.410678835227479 0.358207687012007 no 2172 0.340654024123932 3096 6618304 SGTC_3200 9114385 49.47 µM -0.412441785877334 0.357564508495478 no 2173 0.340007820536806 3259 17018030 YLR208W SEC13 SGTC_2603 homopterocarpin 100 µM -0.415220097265075 0.356551716429902 no 2174 0.338990393930011 3222 101795 A weak amylase inhibitor. SGTC_1924 st058459 75.1 µM -0.41546256406255 0.356463376616642 no 2175 0.338901657364918 3216 688683 SGTC_414 piperonyl butoxide 100 µM -0.415914933567733 0.356298581907071 no 2176 0.33873612574607 3122 5794 A potent inhibitor of cytochrome P450. SGTC_2505 galangin 7.89 µM -0.41815080350438 0.355484466383391 no 2177 0.33791843128061 3061 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1189 1431-2119 7.28 µM -0.419037583257512 0.355161758168094 no 2178 0.337594332762924 3217 3107275 SGTC_2925 9010536 32.5 µM -0.420203765517885 0.354737530639182 no 2179 0.337168302095851 3163 2994177 SGTC_1678 st019265 80.2 µM -0.420643762943903 0.354577517496233 no 2180 0.337007616077174 3345 5367020 SGTC_1439 4092-1168 46 µM -0.421092453996721 0.354414369180949 no 2181 0.33684378579125 3212 2886240 SGTC_2518 prenyletin 46.28 µM -0.421813871319384 0.354152111019676 no 2182 0.336580440031251 3221 3873459 A coumarin with calcium channel inhibitory activity. SGTC_125 0133-0007 11.75 µM -0.426025251397934 0.352622524198019 no 2183 0.335044723040454 3298 26541 SGTC_1854 st056233 32.9 µM -0.426107494982584 0.352592676674843 no 2184 0.335014759522369 3238 5393174 SGTC_856 0433-0016 11.3 µM -0.426553515515702 0.352430824440664 no 2185 0.334852280711356 3239 3911780 SGTC_2671 danthron 100 µM -0.42820697499364 0.35183104925025 no 2186 0.334250219294204 3212 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_945 3381-0768 11.3 µM -0.429842455073371 0.351238158406741 no 2187 0.333655123768666 3299 1126236 YIL048W NEO1 SGTC_709 3807-1509 243 µM -0.432339480993594 0.35033364012542 no 2188 0.332747348165764 3222 1886677 YPL242C IQG1 SGTC_2146 5545642 200 µM -0.433145275952374 0.350041931141233 no 2189 0.33245461608859 3249 825326 SGTC_1531 st059297 52.4 µM -0.43346457533972 0.349926364785471 no 2190 0.332338648114793 3266 7566702 SGTC_573 3702-0553 84.7 µM -0.433738867543555 0.349827099306783 no 2191 0.332239039344752 3181 1222756 SGTC_154 3389-1638 511.116 µM -0.433861879037467 0.349782585170532 no 2192 0.332194371768193 3219 5238686 SGTC_1453 4237-0541 195 µM -0.434606314218535 0.349513240690355 no 2193 0.331924105511944 3284 739892 SGTC_1422 4031-0024 15.5 µM -0.435491543723056 0.349193053938879 no 2194 0.331602837856411 3221 782427 SGTC_1714 st033236 13.627 µM -0.436074231560227 0.348982354799152 no 2195 0.331391436245532 3339 2916566 SGTC_2223 6903751 107.57 µM -0.437106236724606 0.348609297389042 no 2196 0.331017152246528 3233 5598863 SGTC_658 3253-0951 102 µM -0.438359544685191 0.34815643850401 no 2197 0.330562833936681 3210 1184878 SGTC_13 0199-0087 65 µM -0.438610283397277 0.348065864821964 no 2198 0.330471972255424 3224 4589825 SGTC_1946 st076057 65.1 µM -0.44200944855133 0.346838850403241 no 2199 0.329241184337212 3209 953009 SGTC_2890 9046729 58.44 µM -0.442382721404479 0.34670420569697 no 2200 0.329106140096282 3154 903329 SGTC_1447 4239-0816 81.9 µM -0.443753139147555 0.34621004310049 no 2201 0.328610535857384 3194 1341554 SGTC_1072 oxiconazole 14.9 nM -0.445937935847832 0.345422762910497 no 2202 0.327821039206987 3277 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1618 st003135 44.5 µM -0.446657746251777 0.345163529140555 no 2203 0.327561097236018 3243 1270615 SGTC_2325 6158266 200 µM -0.446681953039778 0.34515481252767 no 2204 0.32755235699663 3228 3623240 SGTC_1423 4048-0112 5.59 µM -0.449400269199508 0.344176498670418 no 2205 0.326571468577862 3274 X1423 SGTC_1872 amphotericin b 148 nM -0.450946701323255 0.343620406897176 no 2206 0.326013981678112 3283 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.451684953529244 0.343355053099846 no 2207 0.325747979640374 3279 616764 SGTC_1244 0416-0015 52.5 µM -0.452086623184491 0.343210711323187 no 2208 0.325603289994355 3194 96201 SGTC_1972 st070201 17.4 µM -0.453742059635905 0.342616064442849 no 2209 0.325007245305464 3313 2829099 SGTC_1936 st074407 74.3 µM -0.454605727894512 0.34230598208385 no 2210 0.324696456619662 3179 809813 SGTC_2955 9076254 12.21 µM -0.456175333486429 0.341742719623634 no 2211 0.324131950756981 3285 16459619 SGTC_1125 tnp00248 1.32998 µM -0.45676139474513 0.341532498219434 no 2212 0.323921278404889 3349 24207736 SGTC_1967 st070177 51.4 µM -0.457068236712859 0.341422452959853 no 2213 0.323810999931697 3353 5729214 SGTC_2823 7987624 58.44 µM -0.459993705948551 0.340373945989801 no 2214 0.322760369127574 3419 2239440 SGTC_1860 st056228 74.6 µM -0.460549790254449 0.340174780991372 no 2215 0.322560820824507 3302 688679 SGTC_796 1234-0020 70.7 µM -0.460708796035478 0.340117840291703 no 2216 0.322503771721495 3258 46495034 SGTC_2086 5274770 176.623 µM -0.460874773222705 0.340058406988995 no 2217 0.322444225831002 3271 689278 SGTC_610 4215-0184 155 µM -0.460932956336339 0.34003757365323 no 2218 0.322423353165144 3270 5605015 SGTC_1761 st044296 37 µM -0.461129384763272 0.33996724311955 no 2219 0.322352890378541 3176 1826700 SGTC_3305 9127027 53.8275 µM -0.461271899695945 0.33991621961598 no 2220 0.322301771430336 3196 41905295 SGTC_769 0302-0231 76 µM -0.461280564199664 0.339913117626221 no 2221 0.322298663651616 3311 571869 YER009W NTF2 SGTC_360 0957-0399 1.01 µM -0.462278946793293 0.33955575805867 no 2222 0.321940647634473 3343 6752301 YPR165W RHO1 SGTC_2998 9066762 71.4286 µM -0.462699623364887 0.339405224880342 no 2223 0.32178984414553 3392 4945196 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.463063162093083 0.339275158310571 no 2224 0.321659546983399 3316 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2264 7948757 110.76 µM -0.4645325512735 0.33874963677451 no 2225 0.321133121789221 3135 2971411 SGTC_1484 3473-2379 286 µM -0.464745809925494 0.338673391664645 no 2226 0.321056749307923 3374 671917 SGTC_339 3091-4833 71.4 µM -0.465307367332691 0.33847265298229 no 2227 0.320855679811755 3266 3240077 SGTC_612 0302-0167 22.4 µM -0.467204866767093 0.337794697851295 no 2228 0.320176656012605 3273 235821 SGTC_1932 st074806 40.9 µM -0.469570998839853 0.33695004249583 no 2229 0.319330774307797 3424 17251235 SGTC_184 1494-0393 24.714 µM -0.469834643218084 0.336855978239639 no 2230 0.319236580707922 3172 3090647 SGTC_2605 digitonin 300 nM -0.470954960439325 0.336456380157951 no 2231 0.318836449325708 3414 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1495 4469-0029 237 µM -0.471006988155079 0.33643782724062 no 2232 0.318817872284038 3286 793680 SGTC_2612 dictamnine 15.46 µM -0.471813504909381 0.336150276899899 no 2233 0.318529955265977 3271 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2536 dehydroabietamide 32.04 µM -0.472322336711375 0.335968910552501 no 2234 0.318348364628068 3370 3983547 SGTC_204 PMA1.184 62.41 µM -0.473127128044112 0.335682131330618 no 2235 0.318061241787712 3266 2252213 YGL008C PMA1 SGTC_2702 st077768 96.8 µM -0.473671462717215 0.335488217424115 no 2236 0.317867103199473 3280 6484119 SGTC_669 0108-0021 26.2 µM -0.473897278863993 0.335407785484124 no 2237 0.317786579881358 3517 17201 SGTC_1812 st052057 4.327 µM -0.475013087159844 0.335010463988529 no 2238 0.317388822622629 3224 3645418 SGTC_351 caspofungin 25 nM -0.475353028048937 0.33488945313345 no 2239 0.317267684216907 3256 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_348 k064-0012 10.7 µM -0.476127457785833 0.334613838625364 no 2240 0.316991788214114 3237 5066323 SGTC_938 3126-1755 342 µM -0.480640700524649 0.33300938149143 no 2241 0.315385941677492 3376 1777771 SGTC_961 1252-1571 372 µM -0.481111087429934 0.332842334156334 no 2242 0.31521877419387 3399 6813498 SGTC_271 rotenone 740 µM -0.483445831716134 0.332013693718211 no 2243 0.314389606278021 3367 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3294 9122953 26.2835 µM -0.484290951480513 0.331713948478484 no 2244 0.314089698361048 3284 16459826 SGTC_1689 st020265 53.493 µM -0.486603339971643 0.330894346571985 no 2245 0.313269728094719 3367 5758320 YPR016C TIF6 SGTC_3194 9111903 49.47 µM -0.487679853408224 0.330513063671723 no 2246 0.312888312049782 3407 17087251 SGTC_2715 st079500 56.4 µM -0.488342207370349 0.330278556425295 no 2247 0.312653734984848 3241 28246688 SGTC_2249 haloperidol 116.36 µM -0.488381919849899 0.330264498289254 no 2248 0.312639672955669 3321 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_335 4077-0256 27.6 µM -0.489494721415187 0.32987066630738 no 2249 0.312245745356455 3302 3121989 SGTC_1719 st032227 49.2 µM -0.490051864452074 0.329673558415364 no 2250 0.312048599365837 3251 3125804 SGTC_2211 7117706 200 µM -0.491357681559379 0.329211767575759 no 2251 0.311586744783167 3329 822771 SGTC_2307 7538926 6.34 µM -0.491975451448047 0.32899338934834 no 2252 0.311368348879386 3280 96582 SGTC_2358 9037157 4 µM -0.492354948582486 0.328859268145923 no 2253 0.311234220792441 3327 2388925 SGTC_67 0335-0847 266 µM -0.492499549652708 0.328808169289583 no 2254 0.311183120108614 3480 4552207 YOR254C SEC63 SGTC_905 2-aminofluorene 215 µM -0.492937617914383 0.328653385079741 no 2255 0.311028333042389 3344 1539 An established DNA mutagen. YPR165W RHO1 SGTC_547 1120-0019 610 nM -0.493149022961664 0.328578699098963 no 2256 0.310953647124702 3302 3676939 SGTC_1493 4348-0038 111 µM -0.49375300377631 0.328365360191231 no 2257 0.310740313567387 3367 800424 SGTC_3064 1327-0027 10 µM -0.493763976528456 0.328361484898403 no 2258 0.310736438442599 3290 16000455 YPR107C YTH1 SGTC_1334 1486-0610 236 µM -0.494469306892419 0.328112419182347 no 2259 0.31048738883156 3350 3742339 SGTC_14 0354-0009 295 µM -0.494932283278224 0.327948974844474 no 2260 0.310323960742402 3283 1713507 SGTC_230 MPP+ 141.667 µM -0.496136709741739 0.327523931130729 no 2261 0.309898980375936 3317 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2367 9070478 135.38 µM -0.496216454633806 0.327495796932661 no 2262 0.309870851446711 3322 572802 SGTC_2794 7785382 27.27 µM -0.497203952509883 0.32714748642011 no 2263 0.309522617237287 3374 2205081 SGTC_2378 9074213 121.43 µM -0.499638908889417 0.326289271475638 no 2264 0.308664677859921 3346 657714 SGTC_923 1900-2434 73.3 µM -0.499779692200107 0.326239679614963 no 2265 0.308615105734993 3321 5910570 SGTC_2545 solidagenone 89.61 µM -0.500570335324839 0.325961227393343 no 2266 0.308336772071807 3251 6708572 An anti ulcer agent SGTC_981 1488-1094 54.9 µM -0.50124749415812 0.325722819706948 no 2267 0.308098476347644 3322 3449522 SGTC_1317 1273-0028 910 nM -0.50174498155867 0.325547714441294 no 2268 0.307923459463248 3284 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_161 4065-0411 162.148 µM -0.501750902309357 0.325545630691343 no 2269 0.307921376796393 3326 1906281 YLR208W SEC13 SGTC_340 k038-0059 454 µM -0.502858570362259 0.325155893800955 no 2270 0.307531855462751 3355 23733424 SGTC_1454 4239-0054 42.6 µM -0.503318439060629 0.324994143529739 no 2271 0.307370202238663 3452 1340767 SGTC_2295 7971645 200 µM -0.503739061130215 0.324846226408508 no 2272 0.307222377763136 3279 2978226 YKL099C UTP11 SGTC_1955 wogonin 32.4 µM -0.504192516894113 0.324686793827806 no 2273 0.30706304921302 3472 5281703 A flavanone. SGTC_2920 7982904 15.77 µM -0.504249203818202 0.324666865271311 no 2274 0.30704313396447 3336 6456808 SGTC_132 0417-1715 25.805 µM -0.50435118260029 0.324631015411449 no 2275 0.307007308214888 3439 6769098 SGTC_403 arphamenine a 50 µM -0.50516819411401 0.324343859942921 no 2276 0.306720353773596 3332 5487158 An arginine aminopeptidase inhibitor. SGTC_325 2810-4341 181 µM -0.505837935531794 0.324108543453698 no 2277 0.306485212505846 3387 774970 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.50606596954969 0.324028438761628 no 2278 0.306405169617515 3354 2346 DNA damaging agent; causes G2/M arrest. SGTC_936 3005-4620 401 µM -0.507443622146765 0.323544664912738 no 2279 0.305921792316787 3438 777207 SGTC_252 miconazole 1.30953 nM -0.50755669476047 0.323504971776512 no 2280 0.305882133492713 3346 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_935 2996-0153 430 µM -0.510744244749245 0.32238683839081 no 2281 0.3047650775008 3412 23738523 SGTC_1952 st077036 64.1 µM -0.511033634784899 0.322285405055722 no 2282 0.304663752508919 3378 2937007 SGTC_862 0452-0056 10.2 µM -0.511571228609279 0.322097009593244 no 2283 0.304475562964235 3369 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3128 9127691 49.47 µM -0.511769138515707 0.322027665154245 no 2284 0.304406295854515 3368 41316314 SGTC_1933 st074711 15.9 µM -0.512281761873172 0.321848079011978 no 2285 0.304226913819124 3358 17250958 SGTC_795 0685-0265 78 µM -0.513313153770279 0.321486879999065 no 2286 0.303866142120991 3438 302754 SGTC_198 3454-2873 16.191 µM -0.514156066705284 0.321191812602237 no 2287 0.303571440469752 3312 710957 SGTC_536 3852-0578 10.6 µM -0.514226765997789 0.321167068961661 no 2288 0.303546728181347 3427 2869208 SGTC_2981 9013952 38.96 µM -0.514925209411625 0.320922667427769 no 2289 0.303302641993274 3324 2996344 SGTC_949 1165-0505 146 µM -0.517213871159599 0.320122355679202 no 2290 0.302503435015965 3288 6244267 SGTC_1063 disulfiram 1.84 µM -0.517501028542651 0.320021999882001 no 2291 0.302403225561786 3359 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_638 3970-0837 4.09 µM -0.517851165334708 0.319899651850344 no 2292 0.302281058299885 3329 4118451 YLR208W SEC13 SGTC_163 TUB2.036 7.546 µM -0.518122546128224 0.319804836941356 no 2293 0.302186385261898 3377 15992207 YJR013W GPI14 SGTC_1779 st039427 55 µM -0.518162036160616 0.319791040911295 no 2294 0.302172610004436 3462 1124498 SGTC_1875 nocodazole 6 µM -0.51854340788752 0.319657819721783 no 2295 0.302039591100791 3427 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1695 st026914 34.495 µM -0.519035943499562 0.319485801070037 no 2296 0.30186783819283 3333 3289191 SGTC_2575 plumbagin 510 nM -0.519099196479273 0.31946371270452 no 2297 0.301845784322049 3293 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_412 gemfibrozil 100 µM -0.519474417253412 0.319332696261845 no 2298 0.301714974222151 3392 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1374 2889-5571 141 µM -0.521477651000883 0.318633605889881 no 2299 0.301017035211691 3336 2853281 SGTC_1407 3909-7909 12.3 µM -0.521905994820023 0.318484205695623 no 2300 0.300867892078389 3392 4411780 SGTC_800 3448-7362 155 µM -0.52311327058576 0.318063284045511 no 2301 0.30044771554879 3441 15991913 SGTC_2427 5545055 42.75 µM -0.526231441271077 0.316977208867975 no 2302 0.299363705531826 3350 5372858 SGTC_205 1486-1330 71.903 µM -0.526999200495188 0.31671003559245 no 2303 0.299097071840274 3382 4118834 SGTC_2054 5233173 129 µM -0.527708804078119 0.31646318494421 no 2304 0.298850730826711 3412 6889 SGTC_2963 9082507 9 µM -0.528287701677037 0.316261863679928 no 2305 0.298649833094699 3424 16459611 SGTC_1690 st023502 41.2 µM -0.529829513802836 0.315725938641408 no 2306 0.298115070126323 3415 24207482 SGTC_2993 9054257 71.4286 µM -0.530215312206629 0.315591897856529 no 2307 0.297981327862135 3361 6470217 YGL055W OLE1 SGTC_2236 dapsone 200 µM -0.530285872908985 0.31556738505474 no 2308 0.297956869993569 3415 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2669 eugenol 100 µM -0.530533705657921 0.315481294340429 no 2309 0.297870973044435 3379 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2140 5586273 200 µM -0.531790944321811 0.315044716353105 no 2310 0.297435397707787 3402 854421 SGTC_3235 9132602 49.47 µM -0.532131737763363 0.314926419790514 no 2311 0.297317378595529 3462 4912240 SGTC_2429 5902844 64.44 µM -0.533036905565834 0.314612309232342 no 2312 0.297004016694446 3389 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1028 k015-0029 4.8 µM -0.534842612132823 0.313986095295803 no 2313 0.29637934715023 3407 4588309 SGTC_551 k048-0028 34.9 µM -0.535191649316945 0.313865111865787 no 2314 0.29625867006521 3453 6836383 SGTC_1721 st082152 9.2685 µM -0.535224058440843 0.313853879215281 no 2315 0.296247465988229 3391 5296051 SGTC_595 3909-8003 73.7 µM -0.537800779119065 0.312961368621737 no 2316 0.295357297020118 3444 699517 SGTC_448 monastrol 171 µM -0.5379702658964 0.312902701034308 no 2317 0.295298788290799 3375 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2145 5634607 200 µM -0.538594364241689 0.31268671120517 no 2318 0.295083388565268 3346 308662 SGTC_1621 st003705 32.4 µM -0.538720623646588 0.312643022789677 no 2319 0.295039820515507 3454 24207032 SGTC_1115 galangin 695.678 nM -0.538924119990878 0.312572614305572 no 2320 0.294969606725407 3486 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1326 1431-2094 10.8 µM -0.539512893306232 0.312368940890055 no 2321 0.294766501457938 3330 616278 SGTC_1519 esterone 74 µM -0.542709277976292 0.311264222060152 no 2322 0.29366499258479 3317 698 A steroid. SGTC_2749 bexarotene 57.39 µM -0.543457412117269 0.311005900416709 no 2323 0.293407452858445 3373 82146 An retinoic acid receptor inhibitor. SGTC_1242 0402-0103 60.1 µM -0.547246980458326 0.309698840548908 no 2324 0.292104531872999 3397 432868 SGTC_2155 5570423 76 µM -0.547800356194549 0.309508176402339 no 2325 0.291914497000337 3336 797402 SGTC_2534 helenine 20.12 µM -0.547975069060198 0.309447990191096 no 2326 0.291854510781382 3420 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2219 9098279 200 µM -0.548198203476647 0.30937113084474 no 2327 0.291777907773824 3435 902349 SGTC_1893 st059353 36.1 µM -0.548316643316439 0.309330337259962 no 2328 0.29173725067247 3403 3112488 SGTC_1442 4112-3290 3 µM -0.55085317112939 0.308457259628796 no 2329 0.29086716566501 3412 704353 SGTC_297 0986-0032 24 µM -0.550876442397508 0.308449254616677 no 2330 0.290859188724679 3362 2847425 SGTC_2659 sanguinarine 24.21 µM -0.551243290031017 0.308323075859148 no 2331 0.290733453969668 3357 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3183 9108214 49.47 µM -0.553409542753524 0.307578446296331 no 2332 0.289991502976824 3393 4974831 SGTC_1441 4106-0040 13 µM -0.554829598617181 0.307090744683666 no 2333 0.289505609872534 3442 2904180 SGTC_466 geldanamycin 89.2 µM -0.556273237274333 0.306595293423483 no 2334 0.289012039835175 3355 5288382 HSP90 inhibitor. SGTC_2447 5741742 33.78 µM -0.558999678683831 0.305660553171328 no 2335 0.288080969736306 3445 1776504 SGTC_108 0509-0257 621.132 µM -0.559153092346578 0.305607993970685 no 2336 0.288028621606346 3407 536624 SGTC_1471 k673-0312 37 µM -0.559643305318438 0.305440074880089 no 2337 0.287861380215886 3440 24099884 SGTC_1564 D-Arginine 115 µM -0.560529791426614 0.305136519079123 no 2338 0.287559062522753 3393 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2443 5493264 126.67 µM -0.561750322887925 0.304718796777833 no 2339 0.287143071363062 3474 5340055 SGTC_3033 9090887 49.47 µM -0.562657111788784 0.304408616404396 no 2340 0.286834196996929 3390 19325384 SGTC_2401 5128683 200 µM -0.563979193999136 0.303956630922269 no 2341 0.286384145978235 3372 708373 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.56443796525363 0.303799858940352 no 2342 0.286228053673424 3457 16623 A steroid. SGTC_1193 1488-0126 41.5 µM -0.564665387192499 0.303722157360196 no 2343 0.286150690627679 3455 1384710 SGTC_2888 9058547 12.99 µM -0.56633053131409 0.303153510242191 no 2344 0.285584554603105 3396 16476514 SGTC_1825 st052143 62.6 µM -0.569712780337082 0.301999939879892 no 2345 0.284436260189536 3509 674173 SGTC_35 0133-0054 64.071 µM -0.569823706648643 0.301962140090378 no 2346 0.284398637411649 3411 99677 SGTC_2240 6690706 185.951 µM -0.570130051357271 0.301857759618635 no 2347 0.284294747103875 3375 805876 SGTC_235 0330-0087 5 mM -0.570751218573823 0.301646159832977 no 2348 0.284084147122253 3462 46494818 YHR062C RPP1 SGTC_1032 k061-1018 98.7 µM -0.57076042489279 0.301643024214403 no 2349 0.28408102638131 3542 4005393 SGTC_651 3253-0966 34.4 µM -0.573197547909582 0.300813470485407 no 2350 0.283255472236962 3425 781462 SGTC_3069 9117009 49.47 µM -0.575704437169236 0.299961245002168 no 2351 0.282407487832495 3364 41904981 SGTC_1867 st057372 64 µM -0.576302843141976 0.299757976512529 no 2352 0.282205250733218 3477 688837 SGTC_3101 9120531 49.47 µM -0.576537642924551 0.299678236001517 no 2353 0.282125916916432 3561 24824904 SGTC_1751 st044839 27.194 µM -0.578070464275979 0.299157909815508 no 2354 0.281608273431032 3502 5291326 SGTC_3083 9117465 49.47 µM -0.578863336506993 0.298888925177254 no 2355 0.281340695311441 3464 16420915 SGTC_1968 st069590 43.6 µM -0.57915375626953 0.298790426772801 no 2356 0.281242715314057 3454 6384066 SGTC_1010 4112-3296 15.2 µM -0.579768656711236 0.298581926604686 no 2357 0.281035318448487 3534 704384 SGTC_2053 5265679 138 µM -0.58154364912195 0.297980434505955 no 2358 0.280437054511923 3442 764595 SGTC_2057 5236571 38.335 µM -0.584866145366331 0.296856026535354 no 2359 0.27931886198278 3522 54684039 YBR257W POP4 SGTC_3319 9138450 16.7555 µM -0.588449461306802 0.295645532387714 no 2360 0.278115323397177 3402 2029690 SGTC_2466 5983409 37.09 µM -0.588455464836934 0.295643506216466 no 2361 0.278113309098734 3434 2879657 SGTC_2440 5628896 157.78 µM -0.590304912633443 0.295019627886233 no 2362 0.277493123208854 3477 5522048 SGTC_1770 st043884 66.3 µM -0.591131936235691 0.294740842554542 no 2363 0.277216011542115 3508 670149 SGTC_3282 9108498 15.4605 µM -0.591473291046465 0.294625809061833 no 2364 0.277101672909099 3450 16459645 SGTC_1266 0828-0227 32.9 µM -0.591577972463999 0.294590536518175 no 2365 0.277066613928641 3425 3913820 SGTC_1994 st072947 40.9 µM -0.591812601574419 0.294511485003601 no 2366 0.276988041895567 3527 5286565 YDL195W SEC31 SGTC_3091 9116372 49.47 µM -0.591991124640681 0.294451343362038 no 2367 0.276928265827949 3541 17169793 SGTC_974 1326-0144 138 µM -0.592073948475385 0.294423443226902 no 2368 0.276900535516719 3477 5411856 SGTC_336 4111-0029 111 µM -0.592647683356577 0.294230207731329 no 2369 0.276708480245806 3464 3131175 SGTC_2479 5617353 43.85 µM -0.59334580385226 0.293995157865131 no 2370 0.276474875491649 3542 2731746 SGTC_2788 5282734 71.43 µM -0.593535613037293 0.293931266112405 no 2371 0.276411378355375 3535 743706 SGTC_92 0063-0024 660.874 µM -0.59360147446144 0.293909097970304 no 2372 0.276389347311164 3532 3594437 SGTC_173 1273-0061 2.693 µM -0.594145994651806 0.293725848828244 no 2373 0.276207235021182 3463 2847414 YPL266W DIM1 SGTC_2729 fluphenazine 10.66 µM -0.595591524989239 0.293239636503205 no 2374 0.275724069862535 3439 3372 An atypical antipsychotic. SGTC_1309 pyrazolanthrone 13.4 µM -0.596404157972166 0.292966466722995 no 2375 0.275452631711806 3520 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1307 1187-1599 12.2 µM -0.596718120857297 0.292860958493838 no 2376 0.275347796086912 3414 1538471 SGTC_855 0428-0020 25 µM -0.598117682741095 0.292390845954834 no 2377 0.274880706130113 3492 6812414 SGTC_581 0958-0271 211 µM -0.598574206350636 0.292237575699093 no 2378 0.274728430392016 3468 4591145 SGTC_626 0214-0009 33 µM -0.59897163474171 0.292104176125797 no 2379 0.27459590003523 3537 3437874 SGTC_560 2332-1943 155 µM -0.599574810319818 0.291901770258721 no 2380 0.274394819482402 3524 21177716 SGTC_3231 9132313 49.47 µM -0.6010500735247 0.291406995958409 no 2381 0.2739033176874 3475 4905967 SGTC_365 0121-0052 13.6 µM -0.601309762327573 0.291319941950509 no 2382 0.273816844290161 3523 3101739 SGTC_2941 9056145 11.23 µM -0.602184943164256 0.291026649442566 no 2383 0.273525518544016 3471 2119517 SGTC_3351 9150312 21.596 µM -0.604642696070258 0.290203740449926 no 2384 0.272708215502018 3503 4904905 SGTC_2478 5763493 32.33 µM -0.604645971625782 0.29020264445064 no 2385 0.272707127055396 3496 1365576 YLR208W SEC13 SGTC_1308 1187-1617 41.4 µM -0.606308712654533 0.289646542621328 no 2386 0.272154887058028 3526 2882570 SGTC_1372 2752-0194 270 µM -0.608227342216706 0.289005481462008 no 2387 0.271518351308719 3509 823334 SGTC_2296 7971656 126.45 µM -0.608540250344592 0.28890099452564 no 2388 0.271414609451774 3501 666570 SGTC_2369 9071472 200 µM -0.608905046712644 0.288779203408286 no 2389 0.271293689456111 3533 17296037 SGTC_976 1348-1067 47.6 µM -0.609340792686814 0.288633756705464 no 2390 0.27114928681137 3565 5310671 YGL099W LSG1 SGTC_3118 9124250 49.47 µM -0.610378092426518 0.288287657588197 no 2391 0.270805688464017 3444 1504786 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.610462758665741 0.288259417007459 no 2392 0.27077765295605 3545 688798 SGTC_2988 9073640 71.4286 µM -0.611357916367739 0.287960915352177 no 2393 0.270481328309635 3594 9102229 SGTC_3186 9110464 49.47 µM -0.612661034100415 0.287526635303469 no 2394 0.270050246212834 3558 17018021 SGTC_3174 9107204 49.47 µM -0.613135320931182 0.287368650270634 no 2395 0.269893433584923 3560 3938802 SGTC_2288 7946289 167.31 µM -0.617182220152285 0.286022300316888 no 2396 0.268557270884295 3591 1246052 SGTC_83 0170-0301 39.027 µM -0.618612240977323 0.285547269066354 no 2397 0.268085917920144 3494 3089716 SGTC_1590 st077108 57.8 µM -0.618959027615104 0.285432128400447 no 2398 0.26797167542413 3536 5489485 SGTC_2339 9000433 200 µM -0.619416776998792 0.285280179561176 no 2399 0.267820915831032 3473 2988954 SGTC_982 1491-0518 27.5 µM -0.620331362133743 0.284976700631809 no 2400 0.267519825575429 3486 3091256 SGTC_734 2023-0417 80 µM -0.620361844919209 0.284966588442761 no 2401 0.267509793288088 3522 3935732 SGTC_2781 5567276 71.43 µM -0.624832909776478 0.28348523891401 no 2402 0.266040364401248 3568 2853274 SGTC_1574 spiramycin 23.7 µM -0.626173799817408 0.283041696820848 no 2403 0.265600475112019 3571 6419898 An antibiotic and protein synthesis inhibitor. SGTC_144 4161-2749 112.381 µM -0.626820879581482 0.282827773798589 no 2404 0.265388327658634 3496 797501 YMR168C CEP3 SGTC_40 0327-0103 19.753 µM -0.629573310351819 0.281918695533616 no 2405 0.264486895129128 3487 409036 SGTC_1785 bathophenanthroline 24 µM -0.62970982188319 0.281873644901269 no 2406 0.264442227622983 3506 72812 An iron chelator. SGTC_2025 5147754 141 µM -0.630027151039869 0.281768935438274 no 2407 0.264338410191141 3569 315777 YLR208W SEC13 SGTC_3318 9139014 38.6185 µM -0.631279801408937 0.281355780149947 no 2408 0.263928795719286 3557 16643984 SGTC_933 2914-0560 114 µM -0.632556549245999 0.280934978036119 no 2409 0.263511634607128 3590 463887 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.634991141550941 0.280133407126557 no 2410 0.262717096247934 3515 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1947 st076332 61.6 µM -0.636967350250088 0.279483571510405 no 2411 0.262073055460266 3560 24208416 SGTC_341 1486-1430 230 µM -0.637879218150211 0.279183969510671 no 2412 0.261776153389066 3547 2054753 YPL210C SRP72 SGTC_120 rhodamine 6G 52.259 µM -0.638888872087811 0.27885242130513 no 2413 0.261447613827315 3589 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_316 k060-0003 58.6 µM -0.63900007862858 0.278815915233497 no 2414 0.261411440369328 3606 6152314 SGTC_2070 5230947 200 µM -0.639871921646996 0.278529793593565 no 2415 0.261127934838552 3638 2835538 SGTC_1197 1601-0112 267 µM -0.640466065381907 0.27833488934971 no 2416 0.260934822022735 3559 7350313 SGTC_2884 9058502 51.95 µM -0.640684818191485 0.278263145934833 no 2417 0.260863739934163 3579 6471554 SGTC_2938 9059746 27.26 µM -0.641700356439012 0.277930202369874 no 2418 0.260533878879761 3553 6471769 SGTC_1345 1488-0192 31.4 µM -0.642584415612146 0.277640522524954 no 2419 0.260246899024082 3603 658348 SGTC_27 0485-0001 32.618 µM -0.6433944995277 0.277375211732548 no 2420 0.259984075821859 3534 2054479 SGTC_3075 9116269 49.47 µM -0.643823120416873 0.277234884157135 no 2421 0.259845069678055 3615 17015205 YNL244C SUI1 SGTC_3334 9142812 21.919 µM -0.645172324409801 0.276793390744744 no 2422 0.259407759458411 3586 45283678 SGTC_1042 0350-0096 82 µM -0.645558402349134 0.276667119757267 no 2423 0.259282692094742 3585 3122515 SGTC_2289 7946404 165.07 µM -0.648320211778295 0.275764664072057 no 2424 0.258388932005448 3628 1246120 YPR165W RHO1 SGTC_642 0335-0876 158 µM -0.649613523343315 0.275342556310651 no 2425 0.257970947760002 3606 6812350 SGTC_2870 9038528 12.99 µM -0.651465406410968 0.274738697538971 no 2426 0.25737305054286 3594 6463316 SGTC_3350 9150499 3.57 µM -0.65213070904151 0.274521916370915 no 2427 0.257158427516628 3585 4910996 YPR165W RHO1 SGTC_1935 st074532 41.6 µM -0.653002981112486 0.274237824526191 no 2428 0.2568771783225 3673 2829742 SGTC_593 1203-0218 61.7 µM -0.653432639084455 0.274097941846458 no 2429 0.256738701330813 3631 3666956 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.653627689683215 0.274034451343064 no 2430 0.256675850155589 3613 688669 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.653858234799426 0.273959416467821 no 2431 0.256601571910514 3620 23665772 A membrane-active detergent. SGTC_2245 6637752 200 µM -0.654699246743099 0.273685780781305 no 2432 0.256330705167634 3570 681890 SGTC_2347 9049783 174.81 µM -0.656162624727241 0.273209971636115 no 2433 0.255859746992395 3604 6467988 YPL169C MEX67 SGTC_2691 st077356 60.2 µM -0.656523565119959 0.27309267693128 no 2434 0.255743655203457 3641 2839272 SGTC_2291 7917025 104.35 µM -0.657135442167641 0.272893892441931 no 2435 0.25554691574267 3569 2964612 SGTC_1103 duloxetine 36.1 µM -0.657178845022124 0.272879794599444 no 2436 0.25553296323963 3665 60835 A selective serotonin reuptake inhibitor. SGTC_1755 st041960 45.185 µM -0.658436793533636 0.272471352680664 no 2437 0.255128749671036 3613 2257073 SGTC_1681 tripelennamine 100 µM -0.660335305523413 0.271855502304848 no 2438 0.254519339171441 3613 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1548 st061468 90.8 µM -0.661989626949278 0.271319429156636 no 2439 0.253988934795884 3608 390799 SGTC_2121 5257820 149.641 µM -0.662986342928649 0.270996703710396 no 2440 0.253669650430703 3641 791256 SGTC_1475 4092-1048 11.7 µM -0.66492168050998 0.270370610553318 no 2441 0.25305029397421 3623 2881759 SGTC_177 1327-0068 8.361 µM -0.665790511329085 0.270089773980076 no 2442 0.25277250534336 3621 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2468 5987765 72.9 µM -0.667382609345625 0.269575531111733 no 2443 0.252263885677149 3636 26772094 SGTC_1024 4507-0395 26 µM -0.668433970723415 0.269236213713844 no 2444 0.251928308537987 3659 4201836 SGTC_1049 3226-0134 66 µM -0.670592783279019 0.268540148677925 no 2445 0.25123999057588 3659 5702385 SGTC_166 k072-0058 166.424 µM -0.670867333759222 0.26845169035963 no 2446 0.251152523958742 3645 5846229 SGTC_3313 9133968 57.047 µM -0.671189465234124 0.268347920447669 no 2447 0.25104991947045 3610 1494643 SGTC_2136 5328288 199.296 µM -0.671386529031189 0.268284449194337 no 2448 0.250987162152141 3594 262395 SGTC_832 4083-0019 164 µM -0.67174383376595 0.268169386034639 no 2449 0.250873395369815 3717 1990758 SGTC_3016 9080866 49.47 µM -0.671914410525124 0.26811446380919 no 2450 0.250819092901805 3628 17066299 SGTC_478 N-arachidonylglycine 10 µM -0.672407348024654 0.267955779849464 no 2451 0.250662203089321 3572 5283389 SGTC_1143 3454-2408 5.08 µM -0.673821432054318 0.267500827620438 no 2452 0.250212423706658 3594 X1143 SGTC_2813 7971799 71.43 µM -0.673996787959444 0.26744443765043 no 2453 0.250156677889773 3655 2234054 SGTC_750 4073-0104 132 µM -0.676005264652363 0.266798990846428 no 2454 0.249518651253545 3510 22330957 SGTC_916 4466-0038 42 nM -0.677431398323568 0.266341164977493 no 2455 0.249066141233822 3685 5722064 YGL116W CDC20 SGTC_350 k064-0020 19.8 µM -0.681754814497051 0.264955670106164 no 2456 0.247697000251227 3643 2790705 SGTC_430 0958-0115 16.4 µM -0.681760328644686 0.264953905367294 no 2457 0.247695256599059 3625 6833180 SGTC_2522 biochanin a 4.94 µM -0.682115244195335 0.264840331335777 no 2458 0.247583041027502 3608 5280373 A possible chelator. SGTC_1097 itavastatin 7.23 µM -0.683235999539471 0.264481848830372 no 2459 0.24722886409844 3671 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_521 r062-0005 13.8 µM -0.683624684258143 0.264357582626019 no 2460 0.247106096703066 3577 2832033 SGTC_2372 9071633 200 µM -0.686217211522666 0.263529487968886 no 2461 0.246288072910512 3672 21321366 SGTC_2996 9066192 71.4286 µM -0.686918345752624 0.263305762120392 no 2462 0.246067092700318 3659 6472854 SGTC_525 k781-2675 26.7 µM -0.689040510460149 0.262629189365812 no 2463 0.245398887403838 3695 3651118 YDL195W SEC31 SGTC_1160 4092-0570 10.5 µM -0.69050904435614 0.26216152365741 no 2464 0.244937062127254 3657 4994975 SGTC_543 3844-1095 191 µM -0.691612309980204 0.261810461316216 no 2465 0.244590414486182 3670 4230703 SGTC_1429 4049-0205 9.46 µM -0.692225931500376 0.261615309567315 no 2466 0.244397728134678 3691 22774478 SGTC_362 0310-0100 9.03 µM -0.693433404639224 0.261231511664269 no 2467 0.244018802450934 3707 790235 SGTC_1740 st038286 13.222 µM -0.69426997440499 0.260965775941452 no 2468 0.243756458538183 3677 716786 SGTC_1887 st057648 70.8 µM -0.695410653770053 0.260603664160511 no 2469 0.243398992912394 3652 688672 SGTC_884 0851-0618 334 µM -0.695545641135849 0.260560829174301 no 2470 0.243356709379077 3671 9642473 SGTC_973 1325-0077 65.9 µM -0.696042865615377 0.260403078245738 no 2471 0.243200992694255 3704 2835149 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.69730451013662 0.260003026008954 no 2472 0.242806123070685 3716 94937 An inhibitor of serotonin biosynthesis. SGTC_497 capsazepine 133 µM -0.697678340681587 0.259884549755307 no 2473 0.242689188222572 3666 2733484 A calcium channel blocker. SGTC_2304 7443016 91.4 µM -0.698632507036767 0.259582276869005 no 2474 0.242390861585984 3629 939854 SGTC_2763 lisinopril 49.32 µM -0.70033601515867 0.259043069709935 no 2475 0.241858742508504 3639 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2953 9074162 66.49 µM -0.700533161970128 0.258980704739079 no 2476 0.24179720137144 3624 16451992 SGTC_514 4466-0038 2.65 nM -0.701022289977296 0.258826008647118 no 2477 0.241644552400221 3626 5722064 SGTC_831 k061-1017 217 µM -0.702243015760583 0.258440139440429 no 2478 0.241263811873588 3728 1240153 SGTC_3219 9131112 49.47 µM -0.703540007556225 0.258030489447943 no 2479 0.240859641683679 3628 17612988 YMR079W SEC14 SGTC_2852 9023854 51.95 µM -0.706741950388541 0.257020611700846 no 2480 0.23986342738719 3758 19798528 SGTC_392 N-ethylmaleimide 8.33 µM -0.706829112344426 0.256993150002096 no 2481 0.239836340316359 3665 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1015 4130-4525 82 µM -0.707505383668559 0.256780132320985 no 2482 0.239626234128052 3697 1363237 SGTC_3084 9116877 49.47 µM -0.709832941239873 0.256047681615943 no 2483 0.238903869448558 3613 27241325 SGTC_1026 k007-1105 30.6 µM -0.710728192343899 0.255766248756252 no 2484 0.238626342941224 3702 7066794 SGTC_10 0279-0212 42.575 µM -0.713545295667208 0.254881713454683 no 2485 0.237754197344724 3700 39851 YBR002C RER2 SGTC_1521 st012942 49.4 µM -0.713593622602623 0.254866553380329 no 2486 0.237739251103359 3742 24207259 SGTC_3150 9097574 49.47 µM -0.713622214015059 0.254857584526913 no 2487 0.237730408779302 3672 17217476 SGTC_2586 curcumin 80 µM -0.714987374917366 0.254429538897837 no 2488 0.237308422273444 3715 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2971 9092186 9.93 µM -0.716031616730359 0.25410237180781 no 2489 0.23698591332319 3696 25236400 SGTC_63 0099-0242 26.702 µM -0.717311984568345 0.253701526414297 no 2490 0.236590807005376 3741 3898502 YLR359W ADE13 SGTC_1777 st045864 34.765 µM -0.71832659207591 0.253384118725207 no 2491 0.236277968748652 3701 4691462 SGTC_2756 carbadox 75.1 µM -0.719138878339207 0.25313015531406 no 2492 0.23602767733335 3723 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3260 9137109 49.47 µM -0.719313977881792 0.253075427533581 no 2493 0.235973742702918 3566 17478346 SGTC_2663 amphotericin b 100 µM -0.720022086657479 0.252854169945089 no 2494 0.23575569842797 3701 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2161 5662504 8.5105 µM -0.720524578367122 0.252697221812277 no 2495 0.235601036168779 3689 2859334 SGTC_2606 farnesol 9.78 µM -0.721688843443013 0.252333772792436 no 2496 0.235242901413768 3734 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2928 9011484 9.79 µM -0.723199662869887 0.251862550925348 no 2497 0.2347786129625 3723 2994751 SGTC_2499 avocadenofuran 51.48 µM -0.723462487658089 0.251780623804699 no 2498 0.234697896290293 3709 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_343 4130-2827 29.8 µM -0.725134017977172 0.251259907818945 no 2499 0.234184908380891 3768 1118244 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.725523680207492 0.251138601936901 no 2500 0.234065411438794 3724 6312947 SGTC_2003 4023581 200 µM -0.725575298153678 0.251122535060352 no 2501 0.234049584399225 3750 16641307 SGTC_189 3970-0742 2.116 µM -0.726224137544383 0.250920620241648 no 2502 0.233850688519082 3715 2891807 SGTC_679 0422-0091 41.4 µM -0.727108266719312 0.250645623069261 no 2503 0.233579817505153 3718 627384 YHR062C RPP1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.727510155915099 0.250520673324164 no 2504 0.233456748091179 3680 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2192 5915882 198.485 µM -0.727525098657116 0.250516028173125 no 2505 0.233452172910384 3683 2876149 SGTC_928 2764-0428 58.7 µM -0.728289924989164 0.25027833264832 no 2506 0.233218064201918 3764 662578 SGTC_2213 7173844 200 µM -0.729187030847736 0.249999679274407 no 2507 0.232943631672688 3702 892728 SGTC_3344 9148862 3.898 µM -0.729460194406385 0.249914863636978 no 2508 0.23286010418838 3727 4905352 SGTC_3027 9089541 49.47 µM -0.729925819641114 0.249770325021165 no 2509 0.2327177644657 3698 9943819 SGTC_1123 mangostin 811.285 nM -0.730001549144662 0.24974682139108 no 2510 0.232694618840094 3736 5281650 An antioxidant. SGTC_1583 clindamycin 39.6 µM -0.730316460561532 0.249649097160642 no 2511 0.232598384451685 3690 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3127 9126946 49.47 µM -0.731349124488464 0.249328780432599 no 2512 0.232282965979589 3706 27243249 SGTC_1431 4049-0260 9.09 µM -0.733266342627014 0.248734668230143 no 2513 0.231697999459101 3697 3854841 SGTC_1622 st003707 19.4 µM -0.733573880226944 0.248639437943 no 2514 0.231604242462637 3777 10140899 SGTC_871 0574-0004 149 µM -0.734064145777098 0.248487665356934 no 2515 0.231454822112829 3718 9551173 SGTC_2388 9080168 200 µM -0.735018096551969 0.248192490253642 no 2516 0.231164236514518 3703 15943073 SGTC_1977 st070720 65.3 µM -0.735155948347849 0.248149851091476 no 2517 0.231122261935804 3753 682188 SGTC_2837 9008476 45.46 µM -0.735234911740261 0.248125428556844 no 2518 0.231098220239609 3726 2992805 SGTC_2827 7993847 71.43 µM -0.735307459599435 0.248102991408307 no 2519 0.231076133087674 3742 2985692 SGTC_3157 9099274 49.47 µM -0.735820180174398 0.247944451250886 no 2520 0.230920069208738 3693 17217662 SGTC_1513 0337-0559 19 µM -0.736639522266439 0.247691211834597 no 2521 0.230670796889975 3708 775073 SGTC_979 1426-2828 121 µM -0.737148158356606 0.247534073870446 no 2522 0.230516127788424 3836 747872 SGTC_3261 9137475 49.47 µM -0.737446543931912 0.247441915465066 no 2523 0.23042541990235 3616 17027690 SGTC_2399 5884133 200 µM -0.740843695627489 0.246393976151153 no 2524 0.229394108871312 3757 722445 SGTC_3287 9117173 37.0625 µM -0.742180406586075 0.245982286126561 no 2525 0.228989019084043 3738 2789709 SGTC_2071 5230951 39.92 µM -0.743719293185372 0.245508785983482 no 2526 0.22852315746773 3773 1799272 SGTC_2907 7721985 69.9 µM -0.743810852506981 0.245480629530463 no 2527 0.228495456833463 3737 3267881 SGTC_1562 morin hydrate 59.1 µM -0.74431667466147 0.245325109654515 no 2528 0.228342457868862 3783 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3257 9139206 32.98 µM -0.745536797471939 0.24495018923577 no 2529 0.227973637280606 3742 4910041 SGTC_879 0831-1030 162 µM -0.746086239583021 0.24478145690644 no 2530 0.227807660571723 3777 1549252 SGTC_1878 temozolomide 1 mM -0.746956562036024 0.244514311108082 no 2531 0.227544890833005 3678 5394 DNA alkylating agent. SGTC_2215 7188065 200 µM -0.747028058623788 0.244492372187411 no 2532 0.227523312009601 3737 940217 SGTC_3081 9117243 49.47 µM -0.74735085791118 0.244393333559825 no 2533 0.227425900326767 3762 45595589 SGTC_2610 ononetin 44.17 µM -0.748164467367573 0.244143804530639 no 2534 0.227180480294215 3773 259632 SGTC_1764 st044502 93.5 µM -0.748718201806014 0.243974056177147 no 2535 0.227013535286287 3782 8407 SGTC_1512 0259-0544 12.2 µM -0.749205152202758 0.243824833232172 no 2536 0.226866782135517 3730 18476 SGTC_1757 st041620 31.8375 µM -0.749247250843371 0.243811934677288 no 2537 0.226854097303289 3817 5289815 SGTC_776 4476-4378 112 µM -0.749263821739939 0.243806857640044 no 2538 0.226849104400433 3810 2892008 SGTC_557 1315-0110 16.2 µM -0.749951598365458 0.243596185072818 no 2539 0.226641928185359 3756 6833801 SGTC_465 cgp-37157 41 µM -0.753836801301921 0.24240795860709 no 2540 0.225473611516918 3703 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_645 0845-0943 5.41 µM -0.754214630408228 0.242292573457488 no 2541 0.225360176961336 3771 1885106 SGTC_2407 paclitaxel 400 µM -0.754365584135215 0.242246482054257 no 2542 0.225314865589745 3940 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_475 α-linolenic acid 10 µM -0.755065232447376 0.242032917254148 no 2543 0.225104921431581 3811 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_482 fipronil 114 µM -0.755089441642964 0.242025529323859 no 2544 0.225097658938871 3800 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_868 0527-0199 213 µM -0.755318824737987 0.241955534459103 no 2545 0.225028853118877 3728 2849450 SGTC_3299 9121982 43.1275 µM -0.755341373076736 0.241948654562635 no 2546 0.225022090156056 3814 17594604 YPL160W CDC60 SGTC_3165 9101544 49.47 µM -0.755891281272534 0.241780900714371 no 2547 0.224857190887808 3770 5002184 SGTC_1140 3229-1848 2.98 µM -0.756477285706056 0.241602204917774 no 2548 0.224681542977689 3795 2849525 SGTC_486 niguldipine 82 µM -0.75702285248882 0.241435904628662 no 2549 0.22451808575019 3778 1236 A calcium channel blocker. SGTC_157 1348-1695 65.819 µM -0.757438147467786 0.241309355631597 no 2550 0.224393704492275 3748 5380510 SGTC_2908 7930301 100 µM -0.758338124146459 0.241035237793695 no 2551 0.224124294840669 3773 2223178 SGTC_2820 7989630 71.43 µM -0.758648582125079 0.240940716783001 no 2552 0.224031401316172 3648 2984098 SGTC_65 0798-0905 34.986 µM -0.758666854649388 0.240935154218892 no 2553 0.224025934593847 3835 3602145 SGTC_2203 7227154 166.4 µM -0.759305339790814 0.240740828965985 no 2554 0.22383496200271 3766 896304 SGTC_3262 9137218 49.47 µM -0.760015846953882 0.240524683858792 no 2555 0.223622556248889 3611 17650664 SGTC_492 tmb-8 126 µM -0.76387231643542 0.239353343362506 no 2556 0.222471668111251 3672 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_378 3970-0959 8.33 µM -0.764351552608972 0.23920800106265 no 2557 0.222328885757385 3815 6615653 SGTC_1089 terbinafine 2.25 µM -0.766305326877772 0.238615961604496 no 2558 0.22174732474209 3775 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1772 st048439 82.2 µM -0.767430423846978 0.238275395022228 no 2559 0.221412822767817 3809 2927068 YDL195W SEC31 SGTC_368 fentichlor 4.58 µM -0.767524852546038 0.238246823594064 no 2560 0.221384761351542 3801 7329 A pesticide. SGTC_296 1222-0039 74.9 µM -0.76776379577751 0.238174534578495 no 2561 0.22131376357501 3757 5984176 SGTC_2448 5185112 27.17 µM -0.768374816092183 0.237989733388861 no 2562 0.221132268877599 3777 5718189 SGTC_3291 9121177 71.43 µM -0.768794495823523 0.237862848112096 no 2563 0.221007658467243 3783 17015612 SGTC_793 0488-0545 106 µM -0.769012030312563 0.237797093694637 no 2564 0.220943084408657 3789 292548 SGTC_886 0866-0150 153 µM -0.769124158407098 0.237763204491817 no 2565 0.220909803945971 3801 271463 SGTC_1959 st077091 55.8 µM -0.771101050804046 0.237166150745934 no 2566 0.220323518908787 3792 821356 YKL052C ASK1 SGTC_2475 5812728 15.03 µM -0.771531639658811 0.23703621521562 no 2567 0.220195938003706 3776 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_512 prima-1 270 µM -0.771697601545318 0.236986144604164 no 2568 0.220146775802129 3801 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.772767724006583 0.236663428869719 no 2569 0.219829929065754 3811 5282362 SGTC_1686 st019653 115.5 µM -0.773401703068543 0.236472354546333 no 2570 0.219642341190903 3764 97252 SGTC_1611 st001856 99.4 µM -0.773487506576194 0.236446500836683 no 2571 0.219616959880921 3773 647478 SGTC_2862 9027634 71.43 µM -0.773510976545011 0.236439429301687 no 2572 0.219610017584545 3727 5012562 SGTC_3263 9137018 49.47 µM -0.773891810983119 0.236324699614957 no 2573 0.219497386326913 3780 43844957 SGTC_1132 3456-3614 2.5 µM -0.774150567000193 0.236246764606075 no 2574 0.219420878529403 3887 3125502 SGTC_2027 5150920 200 µM -0.775620217398764 0.235804387586225 no 2575 0.218986629759379 3760 786715 SGTC_3002 9075603 71.4286 µM -0.776159949619156 0.23564203842466 no 2576 0.218827275163872 3773 20105405 SGTC_1600 coumarin 106 71.1 µM -0.779396790086356 0.2346697052544 no 2577 0.217873007056843 3900 100336 A hepatotoxic, DNA x-linker. SGTC_3199 9111318 49.47 µM -0.779885995181574 0.234522943352882 no 2578 0.217728991268981 3768 8548020 SGTC_2477 5967686 25.23 µM -0.780617623802818 0.234303548988493 no 2579 0.217513711582055 3815 776118 SGTC_1486 3970-0793 4.53 µM -0.781365856910969 0.234079292962766 no 2580 0.217293673203354 3854 2844330 SGTC_1066 ketoconazole 628 nM -0.781457077798535 0.234051960906766 no 2581 0.217266856004575 3858 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2144 5628481 200 µM -0.784216805053256 0.233225913850778 no 2582 0.216456453017724 3797 2818399 SGTC_2324 6149169 200 µM -0.784981042266877 0.232997447277152 no 2583 0.216232341908557 3746 2888231 SGTC_122 0236-0016 402.397 µM -0.785768266639291 0.23276223877159 no 2584 0.216001630390816 3833 6808838 SGTC_706 4262-0057 46.9 µM -0.786232899150455 0.232623476865265 no 2585 0.215865527683745 3793 883298 SGTC_3155 9099265 49.47 µM -0.786491478388293 0.232546272427939 no 2586 0.215789804763186 3819 25236499 SGTC_2932 9016711 44.54 µM -0.787140351626681 0.232352600000599 no 2587 0.215599855082739 3808 7117328 SGTC_20 0481-0013 4.944 µM -0.78765816551847 0.232198109904422 no 2588 0.215448341002154 3827 182045 SGTC_3240 9133527 49.47 µM -0.787679448041971 0.232191761473588 no 2589 0.215442114986195 3766 17617455 SGTC_3105 9121040 49.47 µM -0.787881925662738 0.23213136861887 no 2590 0.21538288715064 3634 41448907 SGTC_1002 4049-0206 172 µM -0.788840743810292 0.231845501381554 no 2591 0.215102546328472 3832 4662749 SGTC_2834 9001755 58.44 µM -0.789459358835369 0.231661168266796 no 2592 0.214921787137681 3770 2989575 SGTC_765 1319-0117 244 µM -0.790728171709708 0.231283346752662 no 2593 0.214551316437299 3773 3487746 YGL099W LSG1 SGTC_80 0159-0065 512.242 µM -0.791944577529084 0.23092145373224 no 2594 0.214196496459968 3739 1548079 SGTC_2906 7926292 26.41 µM -0.79213309493379 0.230865396209454 no 2595 0.214141537372596 3788 2966319 SGTC_764 1951-2361 146 µM -0.792281772479032 0.230821190824964 no 2596 0.214098198716276 3798 5438930 SGTC_1313 1220-0047 237 µM -0.792400646997088 0.230785849993115 no 2597 0.214063551144765 3813 3528706 SGTC_3269 9137823 49.47 µM -0.792593693717832 0.230728464555855 no 2598 0.214007292043982 3748 17682936 SGTC_817 1391-0715 46 µM -0.793004000143447 0.230606522561803 no 2599 0.21388774610568 3830 1353946 SGTC_1359 1582-0056 520 nM -0.794511241482301 0.23015888364895 no 2600 0.21344893361984 3905 3661189 SGTC_1246 0422-0085 105 µM -0.79477115365504 0.230081740931073 no 2601 0.213373316861778 3833 264295 SGTC_1331 1472-0049 76.2 µM -0.794799590122708 0.230073301779671 no 2602 0.213365044732323 3772 24051409 SGTC_1151 3909-8316 15.3 µM -0.795966208229997 0.229727231369658 no 2603 0.213025838321548 3869 800431 SGTC_1047 2043-3044 82 µM -0.797396279136206 0.229303407227511 no 2604 0.212610459785129 3840 669592 SGTC_2089 5281248 129.67 µM -0.798813885809812 0.228883710061318 no 2605 0.212199168838834 3821 2737878 SGTC_2970 9090938 41.86 µM -0.799906278300257 0.228560590259105 no 2606 0.21188254998594 3845 17217104 SGTC_2266 7929956 200 µM -0.800100864657969 0.228503060273938 no 2607 0.21182618012292 3790 2967153 SGTC_2246 7293507 91.5585 µM -0.801502959359474 0.22808876773515 no 2608 0.211420265763882 3881 887656 SGTC_3116 9124943 49.47 µM -0.801859601971169 0.227983453998415 no 2609 0.211317088427556 3802 41905195 YPL160W CDC60 SGTC_2811 7967822 32.47 µM -0.803136010859965 0.227606764778626 no 2610 0.21094806285782 3912 2232244 SGTC_2978 9011784 42.97 µM -0.803175216830669 0.227595200002869 no 2611 0.210936733911792 3865 2994934 SGTC_1579 chlormadinone acetate 49.4 µM -0.805999519222203 0.226762972681385 no 2612 0.210121563157933 3875 45114258 A steroidal progestin. SGTC_2083 5306046 65.942 µM -0.806367191146072 0.226654758535663 no 2613 0.210015579311215 3873 539837 SGTC_3068 9116768 49.47 µM -0.807456199833452 0.226334409767806 no 2614 0.209701849761639 3790 41904888 SGTC_2267 7931562 200 µM -0.808965409307296 0.225890875531947 no 2615 0.209267521614832 3746 934880 SGTC_1201 1889-3372 45.9 µM -0.810213658757531 0.225524405226383 no 2616 0.208908694303233 3742 5392199 SGTC_1715 st032160 10.2275 µM -0.810422400038944 0.225463154275002 no 2617 0.208848724005075 3770 5289825 SGTC_1164 k060-0068 93.7 µM -0.810505938259107 0.225438644294845 no 2618 0.208824726745592 3847 5963676 SGTC_2050 5263056 171 µM -0.811454805326866 0.22516035410513 no 2619 0.208552268442856 3882 763468 YGL055W OLE1 SGTC_313 3474-0040 5.03 µM -0.812426788576486 0.224875486133734 no 2620 0.208273389972748 3835 1043375 YIL048W NEO1 SGTC_315 k915-0449 187 µM -0.81433689572139 0.224316269369125 no 2621 0.207725989302483 3879 20970215 YNL149C PGA2 SGTC_986 1493-0483 84 µM -0.816673074564057 0.2236333872621 no 2622 0.207057641232548 3778 40079 SGTC_505 gw-5074 63.9 µM -0.816784798921798 0.223600759064278 no 2623 0.207025710366337 3897 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1567 st069303 68.4 µM -0.817612697392598 0.223359062367421 no 2624 0.206789187453239 3941 5581319 SGTC_2747 doxorubicin 7.63 µM -0.818573892085003 0.223078637755981 no 2625 0.206514783825437 3751 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_496 calpeptin 138 µM -0.819158506933246 0.222908176865821 no 2626 0.206347992449247 3846 73364 A calpain inhibitor. SGTC_1349 flufenamic acid 69 µM -0.819163894687142 0.222906606259892 no 2627 0.206346455687391 3806 3371 A non-steroidal anti-inflammatory. SGTC_433 pimozide 108 µM -0.82262337043768 0.22189942292007 no 2628 0.20536110218195 3787 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2857 9024691 58.44 µM -0.822964495544643 0.221800249554301 no 2629 0.205264092010848 3947 16478292 SGTC_3020 9089140 49.47 µM -0.823674337863783 0.221593962306243 no 2630 0.205062312234068 3930 17217859 SGTC_3030 9087619 49.47 µM -0.825579258846296 0.221040915583077 no 2631 0.204521402428026 3905 25236973 SGTC_950 1165-0508 94.1 µM -0.828412388157151 0.220219849356521 no 2632 0.20371849657877 3898 6148369 SGTC_1704 st028805 70.8 µM -0.828556717333222 0.220178068339991 no 2633 0.203677644211286 3898 2876101 SGTC_2123 5259487 200 µM -0.831482538372733 0.219332070082312 no 2634 0.202850544314359 3877 2173474 SGTC_540 1187-0821 17.3 µM -0.831677360846699 0.219275803770681 no 2635 0.202795541320695 3831 847520 SGTC_3133 9127736 49.47 µM -0.831959910477723 0.219194215886808 no 2636 0.202715786709179 3833 27243420 SGTC_1283 0922-0125 16.4 µM -0.833677184471813 0.218698718328524 no 2637 0.202231459133023 3890 3360884 SGTC_3076 9116187 49.47 µM -0.833730679907145 0.218683293262669 no 2638 0.20221638279234 3872 27241210 SGTC_1871 st057448 67.3 µM -0.837779965790629 0.217517526542288 no 2639 0.201077146269233 3918 691747 SGTC_2628 lathosterol 100 µM -0.837991980103928 0.217456587794308 no 2640 0.201017603860984 3975 6710616 SGTC_2745 rifampicin 24.3 µM -0.838723043880064 0.217246535546861 no 2641 0.200812371972699 3869 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_4 0960-0234 25.671 µM -0.840167229993585 0.216831930661643 no 2642 0.20040731465965 3891 6821112 SGTC_1793 st048256 72.231 µM -0.840277890599333 0.21680018048793 no 2643 0.200376297443729 3768 672022 SGTC_844 0330-0132 15.3 µM -0.841627175765905 0.216413266771401 no 2644 0.199998336416399 3919 2828079 SGTC_2022 5136654 200 µM -0.842534205846335 0.216153396499603 no 2645 0.199744500736985 3941 1713771 SGTC_2860 9025725 38.96 µM -0.842903802362577 0.216047556432825 no 2646 0.199641123404216 3887 40546248 SGTC_1020 4335-0961 93.3 µM -0.843824117870979 0.215784139366811 no 2647 0.199383848127532 3836 669075 SGTC_2585 alliin 100 µM -0.844056444842724 0.215717671080562 no 2648 0.199318932420896 3937 87310 A garlic compound which reacts with lipids. SGTC_2569 tetrandrine 100 µM -0.84449509950727 0.215592205216646 no 2649 0.199196400308561 3920 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3213 9129884 49.47 µM -0.846394553981276 0.215049403781617 no 2650 0.19866633779412 3905 17190742 SGTC_2506 ethyl hematommate 54.16 µM -0.846692226601875 0.214964410745069 no 2651 0.198583346318101 3982 3940691 An allergen. SGTC_737 1950-0117 57.9 µM -0.846800574834344 0.214933479436898 no 2652 0.198553143895257 3833 5393513 SGTC_674 0498-0004 451 µM -0.847958703235565 0.214603017877441 no 2653 0.198230484953147 3914 4231473 SGTC_220 paclitaxel 373.376 µM -0.848015752595211 0.214586746989823 no 2654 0.198214598970129 3847 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3283 9109332 35.8195 µM -0.848162082385875 0.214545015959923 no 2655 0.198173855443347 3747 17027281 SGTC_1926 methyl fluorone black 53.6 µM -0.848571146236034 0.214428382205481 no 2656 0.19805998404062 3687 72721 Reacts with homocysteine. SGTC_591 4299-0174 154 µM -0.849379928029915 0.214197887981069 no 2657 0.197834959180556 3884 5509088 SGTC_3218 9131285 49.47 µM -0.849788816066226 0.214081414114271 no 2658 0.197721254333399 3858 17156417 SGTC_3009 9080819 71.4286 µM -0.850553253858233 0.213863758964047 no 2659 0.197508783076633 3916 17027216 SGTC_2592 piperlongumine 83.33 µM -0.852231353058192 0.213386412998161 no 2660 0.197042849068535 3928 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1491 4138-0063 26.5 µM -0.85341813190798 0.213049201485527 no 2661 0.196713734969196 3849 23883227 SGTC_2566 crystal violet carbinol 226 nM -0.853970345109317 0.212892401591415 no 2662 0.196560710361522 3959 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1416 3966-0321 25.3 µM -0.853999950792516 0.212883997016321 no 2663 0.19655250832489 3921 582530 YLR208W SEC13 SGTC_2625 euphol 100 µM -0.854066095260183 0.212865220370344 no 2664 0.196534184236157 3941 6708538 A triterpene alcohol. SGTC_1807 st050092 58.9 µM -0.854256103569202 0.21281128746822 no 2665 0.196481551742592 3932 5008496 SGTC_358 0075-0058 9.45 µM -0.854359895356919 0.212781830060668 no 2666 0.196452804920106 3796 1069125 SGTC_851 0394-0702 453 µM -0.854508254530425 0.212739728004783 no 2667 0.196411718861633 3862 762646 SGTC_2174 5790901 200 µM -0.854520259048841 0.212736321519451 no 2668 0.196408394601035 3936 786020 SGTC_900 1112-0045 141 µM -0.855148058640319 0.212558217143008 no 2669 0.196234593467218 3819 56211 YIL048W NEO1 SGTC_2385 9074692 200 µM -0.855280508845115 0.212520652647939 no 2670 0.196197937637035 3934 17046906 SGTC_2064 5220758 200 µM -0.856311143261124 0.212228484658656 no 2671 0.195912849599417 3985 788518 SGTC_3177 9107506 49.47 µM -0.85711073046443 0.212001976595451 no 2672 0.195691845722568 3831 8897194 SGTC_2784 7567673 72.73 µM -0.858368313637584 0.211646013064056 no 2673 0.195344559271434 3892 3471247 SGTC_2876 9059903 25.97 µM -0.860766286480955 0.210968228445695 no 2674 0.194683388312394 3847 6916095 SGTC_2280 7785178 200 µM -0.863097997642909 0.210310394518995 no 2675 0.194041794391823 3926 2954328 SGTC_673 1082-0474 110 µM -0.863422641055399 0.210218900124865 no 2676 0.193952567750562 3926 3098046 SGTC_438 sphingosine 6.67 µM -0.864058751285135 0.210039692695901 no 2677 0.193777808496989 3889 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_568 1193-0097 7.48 µM -0.8644588659862 0.209927016839097 no 2678 0.193667933747107 3790 3646150 SGTC_683 panaxydol 45 µM -0.866082345026022 0.209470195346685 no 2679 0.193222503122591 3907 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2926 9010726 65.15 µM -0.867744483161523 0.209003102249224 no 2680 0.19276711408085 3963 2994293 SGTC_2948 9070189 9.45 µM -0.870087735948882 0.208345645791016 no 2681 0.192126229659231 3866 6473636 YDL196W YDL196W SGTC_2310 7668677 200 µM -0.873228530214124 0.207466335825119 no 2682 0.191269263512967 3929 2197143 SGTC_2433 5607874 27.82 µM -0.873342969131955 0.207434338497745 no 2683 0.191238083144584 3925 2252428 SGTC_1635 st007035 42.4 µM -0.873361466304151 0.207429166928985 no 2684 0.191233043642497 3914 3716403 SGTC_629 3448-6466 76.7 µM -0.87526901973282 0.206896249123261 no 2685 0.190713773303705 3931 573744 SGTC_939 1165-0479 45.3 µM -0.877274195327603 0.20633693291721 no 2686 0.19016886235896 3900 1377347 SGTC_582 0987-0078 156 µM -0.879423930868057 0.205738290114338 no 2687 0.189585730698476 3976 1625765 SGTC_1361 1608-0041 5.61 µM -0.880247844790441 0.205509126018494 no 2688 0.189362529873422 3902 X1361 SGTC_3149 9097855 49.47 µM -0.880645764624644 0.205398502565123 no 2689 0.189254790107919 3964 25236625 YMR079W SEC14 SGTC_1670 st016595 4.04 µM -0.880805183502682 0.205354193344453 no 2690 0.189211636847386 3947 597879 SGTC_510 ag-490 170 µM -0.883345062410232 0.204649020105064 no 2691 0.188524931824208 4064 5328779 SGTC_1260 0700-1617 7.75 µM -0.884121453253507 0.204433750395413 no 2692 0.188315326724421 3983 2853078 SGTC_1067 clotrimazole 1.36 µM -0.885446555793603 0.204066651004422 no 2693 0.187957916143427 3958 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2461 5755302 26.15 µM -0.885535870430956 0.204041921884629 no 2694 0.187933841009777 3996 2788904 SGTC_1824 st053723 68.6 µM -0.886933918894549 0.203655067926496 no 2695 0.187557239398902 3992 675225 SGTC_2595 hexamethylquercetagetin 100 µM -0.887699821310729 0.203443320640758 no 2696 0.187351121028943 3932 386331 SGTC_1741 st038134 10.228 µM -0.887998875544255 0.203360677468919 no 2697 0.187270678084115 4018 1272587 SGTC_1252 0493-0875 34.8 µM -0.888800866842785 0.203139147335742 no 2698 0.1870550549674 3942 3960963 SGTC_1098 clofazimine 15.1 µM -0.890210587501597 0.202750096456026 no 2699 0.186676410350236 4028 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_31 0508-1974 57.237 µM -0.892883504396172 0.202013655587341 no 2700 0.185959780855629 3912 6810525 SGTC_1357 1503-1303 39.5 µM -0.892951976723866 0.201994811178009 no 2701 0.185941445336596 3926 292895 SGTC_1187 1391-0724 117 µM -0.894300305710868 0.201623949188789 no 2702 0.185580618224867 4019 6997986 SGTC_2199 6590217 200 µM -0.894914589444556 0.201455123912585 no 2703 0.18541637356421 3872 703109 SGTC_1263 0774-1208 64.8 µM -0.895080120955845 0.201409644929041 no 2704 0.185372129867641 3975 906585 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.895525335558701 0.201287354901667 no 2705 0.185253164265098 3974 1377 SGTC_1596 piperlongumine 63 µM -0.895662533528739 0.201249678805623 no 2706 0.185216513212859 3999 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2623 humulene 100 µM -0.895709391703434 0.201236811995787 no 2707 0.185203996556388 3970 6187145 An anti-inflammatory. SGTC_2699 st077704 54.6 µM -0.895832682195166 0.201202959953662 no 2708 0.185171065970649 3970 645852 SGTC_1638 st008370 60.6 µM -0.896489026656299 0.201022804020999 no 2709 0.184995819205179 3937 24207134 SGTC_69 0096-0274 206.684 µM -0.897403130184129 0.20077205868426 no 2710 0.184751921435641 4121 6741392 SGTC_3226 9131256 49.47 µM -0.898387033559385 0.200502376610466 no 2711 0.184489623408278 3882 17178073 SGTC_780 0109-0199 192 µM -0.898547087975829 0.200458527227368 no 2712 0.184446976541949 4063 610414 SGTC_2519 cryptotanshinone 88.04 µM -0.898688705895521 0.200419733610945 no 2713 0.184409247236361 3953 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_8 0354-0001 70 µM -0.899252572215376 0.200265317563801 no 2714 0.184259071743719 3967 4993152 SGTC_3320 9137005 35.139 µM -0.901322732118732 0.199699012977827 no 2715 0.183708375356495 3989 4908713 SGTC_1834 st055981 52.8 µM -0.901382483360233 0.199682681987951 no 2716 0.183692495789727 4013 471719 YDL150W RPC53 SGTC_2330 7979373 200 µM -0.904045987466997 0.198955519344106 no 2717 0.182985508431483 3934 1863007 SGTC_2646 retinol 96.75 µM -0.905660191563965 0.198515603535179 no 2718 0.182557869515491 3986 445354 A vitamin A analog and teratogen. SGTC_2639 lactacystin 53 µM -0.908499618652005 0.197743205485619 no 2719 0.181807157574158 4028 3870 A proteasome inhibitor. SGTC_213 1246-0773 967 nM -0.909583262226473 0.197448905684665 no 2720 0.18152116449546 3961 6251622 SGTC_2752 diclazuril 33.15 µM -0.909904695909381 0.197361660532967 no 2721 0.181436386530597 3963 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_78 0336-0123 156.75 µM -0.911357304307857 0.196967677083385 no 2722 0.1810535710277 3807 6765896 SGTC_2845 9003024 42.97 µM -0.911590810211047 0.196904388933098 no 2723 0.180992080917877 4067 2990173 SGTC_3216 9129716 49.47 µM -0.912840757482681 0.196565819513686 no 2724 0.180663149496152 3958 8056934 SGTC_3314 9135860 59.4275 µM -0.915875140512285 0.195745374114389 no 2725 0.179866193414943 3982 25252478 SGTC_1524 corynanthine 62.1 µM -0.916635976617444 0.195539983401502 no 2726 0.179666712751693 4122 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_218 alverine citrate 93.75 µM -0.917441815241204 0.195322586850644 no 2727 0.179455584706649 4027 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3055 9094636 49.47 µM -0.918647320044098 0.194997643918191 no 2728 0.179140036260123 4007 25236176 SGTC_1224 0823-0416 294 µM -0.922858984799196 0.193864975178532 no 2729 0.178040348627927 4079 3598164 SGTC_801 0866-0028 10.1 µM -0.925250827824066 0.193223511312064 no 2730 0.177417725014204 3981 6849771 SGTC_219 mitoxanthrone 164.414 µM -0.925730963684923 0.193094900884024 no 2731 0.177292906115841 3968 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3006 9075424 71.4286 µM -0.926783685937103 0.192813098967574 no 2732 0.177019428478551 3946 7465181 SGTC_1828 st055811 49 µM -0.927755998760911 0.192553045067612 no 2733 0.176767076622233 4035 5877589 SGTC_1200 1643-0193 18.4 µM -0.92778715547658 0.192544715467556 no 2734 0.176758994041409 3998 5403974 SGTC_2740 felodipine 17.08 µM -0.931273110111201 0.19161415343771 no 2735 0.175856153927739 4006 3333 L-type calcium channel blocker SGTC_318 1488-0629 67.2 µM -0.932327625334735 0.191333198297182 no 2736 0.175583617595483 4061 3662576 SGTC_1789 tunicamycin 25 nM -0.932431399063936 0.191305563450972 no 2737 0.175556812056692 3934 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2103 5378138 10 µM -0.933329422680038 0.191066522809 no 2738 0.175324954106972 4049 244142 SGTC_1194 1488-0194 225 µM -0.934294072041783 0.190809951533377 no 2739 0.175076110664984 3967 1391452 SGTC_1045 1348-1485 165 µM -0.935101486038243 0.190595363321598 no 2740 0.174868000404488 4015 6810614 SGTC_353 1988-1175 58.3 µM -0.935446446309586 0.190503727649748 no 2741 0.174779135079159 3852 2788357 SGTC_623 k072-0108 16.9 µM -0.935767150333946 0.190418559706459 no 2742 0.174696544131582 3980 5382803 SGTC_187 1488-2104 32.728 µM -0.936078821573582 0.19033581296774 no 2743 0.174616303143183 4020 2852859 SGTC_148 3253-0744 288.01 µM -0.936115174202109 0.190326163013748 no 2744 0.174606945540023 3921 6893655 SGTC_2759 disulfiram 3.38 µM -0.937894748993311 0.189854135098686 no 2745 0.174149250992384 3927 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_62 0180-0423 3.232 µM -0.938582939011311 0.189671787529456 no 2746 0.173972457845234 3968 30102 YGL099W LSG1 SGTC_1572 epiandrosterone 68.9 µM -0.938887217643128 0.189591198123845 no 2747 0.173894326327907 3914 441302 A steroid. SGTC_2046 4110841 106 µM -0.939470092693294 0.189436880187701 no 2748 0.173744720199026 4024 44119630 YMR134W ERG29 SGTC_3327 9140648 26.9345 µM -0.941009092670698 0.189029796930171 no 2749 0.173350099783829 4037 8029710 SGTC_255 tunicamycin 200.472 nM -0.941277775724665 0.188958782448522 no 2750 0.17328126436428 3959 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1557 sumaresinolic acid 42.3 µM -0.942430618402308 0.188654266068437 no 2751 0.172986108709315 3985 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1711 st032263 62.8 µM -0.942952258396275 0.188516577506778 no 2752 0.172852661551918 4011 3958979 SGTC_713 1488-1073 324 µM -0.943534333721998 0.188363010017561 no 2753 0.172703831156405 3960 3312542 SGTC_455 paf C-16 10 µM -0.943752925443451 0.188305359442492 no 2754 0.172647960711815 3986 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1602 st001878 87.6 µM -0.944986191594724 0.187980306365861 no 2755 0.172332962845578 4040 595405 YLR310C CDC25 SGTC_708 3448-5400 146 µM -0.946349159776506 0.187621470846185 no 2756 0.171985263599964 3972 3462195 SGTC_649 1123-0311 367 µM -0.946557095082174 0.187566763898832 no 2757 0.171932257780631 3927 693629 YIL048W NEO1 SGTC_2648 atorvastatin 78.68 µM -0.946819955017826 0.187497620608418 no 2758 0.171865265780514 4040 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3271 9137798 49.47 µM -0.948048127251106 0.187174768103502 no 2759 0.171552476986521 3950 6498326 SGTC_1850 st056238 17 µM -0.950216413786632 0.186605625431317 no 2760 0.171001150078033 4037 5393177 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.951326510413871 0.186314656913744 no 2761 0.170719326682614 3862 6708630 An antioxidant. SGTC_2902 5787006 60.46 µM -0.951735668520228 0.18620748301623 no 2762 0.170615527571372 3993 591003 SGTC_2744 captopril 92.04 µM -0.95174283844469 0.186205605284012 no 2763 0.170613708997181 4052 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1146 3579-1023 7 µM -0.956973767872789 0.184838805095089 no 2764 0.169290247761646 4075 X1146 SGTC_2497 7-hydroxyflavone 100 µM -0.959781737041076 0.184107683906246 no 2765 0.168582537859535 4080 5281894 SGTC_3343 9148379 18.9835 µM -0.962863696962929 0.183307298149199 no 2766 0.167807964971273 4087 1955036 SGTC_1190 1486-1332 13 µM -0.962952772736277 0.183284197456277 no 2767 0.167785612145948 4048 4150046 SGTC_1703 st026983 48.3 µM -0.965253281185911 0.182688218224943 no 2768 0.167208982862406 4072 1104023 SGTC_2533 agelasine 13.65 µM -0.966083481956041 0.182473440434499 no 2769 0.167001204630836 4114 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_664 1222-0054 14.9 µM -0.966987516694423 0.182239740838712 no 2770 0.166775137088189 4018 6813991 SGTC_747 3448-8087 38.7 µM -0.967454517380243 0.182119091049078 no 2771 0.166658433889952 4090 5168703 SGTC_1653 st012112 65 µM -0.969388519008449 0.181619972808011 no 2772 0.166175689231432 4055 720429 SGTC_578 3460-0051 92 µM -0.97061984988191 0.181302643031598 no 2773 0.165868808775161 4139 2876744 SGTC_1273 0849-0096 14.1 µM -0.970960239074519 0.181214981658099 no 2774 0.165784039389591 4075 5286025 SGTC_1866 st057638 64 µM -0.974113553003373 0.180404162469272 no 2775 0.16500008044139 4035 688802 SGTC_739 1486-1183 203 µM -0.974134916762734 0.180398676928523 no 2776 0.164994777304811 4072 4346692 SGTC_2361 9034121 116 µM -0.975313969141759 0.180096095673911 no 2777 0.16470227167308 4049 6496917 SGTC_1814 st052110 31.539 µM -0.9797538287208 0.178959551754331 no 2778 0.163603824064477 4018 674163 SGTC_207 4185-0010 4.486 µM -0.980475625987543 0.178775208876774 no 2779 0.163425697678479 4116 3761753 SGTC_1989 st071868 50.2 µM -0.982209299639532 0.178332927170613 no 2780 0.162998373518608 4050 16414057 SGTC_2137 5261020 140 µM -0.982631033667789 0.178225441922428 no 2781 0.162894532441554 4024 763655 SGTC_3107 9121808 49.47 µM -0.983143644850739 0.178094850255001 no 2782 0.162768373148962 3945 662681 SGTC_1780 st038448 24.544 µM -0.985544241561733 0.177484082699346 no 2783 0.162178405575541 4131 728868 YDL195W SEC31 SGTC_3277 9138724 49.47 µM -0.985804294430596 0.177417998673488 no 2784 0.162114579007059 4014 15943418 SGTC_893 0958-0369 48.9 µM -0.990830456897194 0.176143814627408 no 2785 0.160884187288998 4016 6819948 SGTC_1938 st074717 56.4 µM -0.993334059913472 0.175511292124789 no 2786 0.160273592199131 3964 17250979 SGTC_1694 st024011 44.9 µM -0.99399648757445 0.175344174304317 no 2787 0.16011228873046 4098 2787533 SGTC_383 2324-0395 7.37 µM -0.998119341900061 0.174306326232435 no 2788 0.159110746044309 4087 3146421 SGTC_2738 aclarubicin 5.55 µM -0.999477748215848 0.173965230584816 no 2789 0.158781656572434 4048 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_447 ml7 120 µM -1.00246833497464 0.173215791485376 no 2790 0.158058726253339 4108 4216 Selective myosin light chain kinase inhibitor. SGTC_1230 0170-0365 3.77 µM -1.00248700554271 0.173211119120473 no 2791 0.158054219715881 4139 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2269 7935389 174.42 µM -1.00283965350675 0.173122882998902 no 2792 0.157969116495179 4042 97605 SGTC_2024 5144227 134 µM -1.00626167236634 0.172268146209781 no 2793 0.157144856160828 4151 3475211 SGTC_2910 7948405 25.97 µM -1.00764188105946 0.171924167076121 no 2794 0.15681320771121 4022 2971328 SGTC_76 0433-0009 400.328 µM -1.00804079395641 0.171824830734325 no 2795 0.156717439340028 4184 2841569 SGTC_3114 9122766 49.47 µM -1.01001201668559 0.171334499758679 no 2796 0.156244766428499 4098 17176985 SGTC_963 1269-2853 151 µM -1.01011739355736 0.171308313043678 no 2797 0.156219524932884 4102 3668223 SGTC_2118 5526350 200 µM -1.01509633064756 0.170073937793667 no 2798 0.155029955290134 4142 743594 SGTC_1251 0490-5699 265 µM -1.01932066595227 0.169031124499756 no 2799 0.15402537799397 4166 3883818 SGTC_3292 9120825 59.784 µM -1.01948449729983 0.168990764225301 no 2800 0.153986504672758 4117 24824900 SGTC_375 3970-0961 9.27 µM -1.01977185973481 0.168919986701222 no 2801 0.153918336013714 4055 2898222 SGTC_2825 7998094 58.44 µM -1.02046788998172 0.168748633008409 no 2802 0.153753305183592 4114 2987815 SGTC_174 3553-0389 74.3 µM -1.0208037127011 0.168665997738391 no 2803 0.153673722530167 4193 738071 SGTC_1646 st011709 75.6 µM -1.02217009310814 0.16833004331419 no 2804 0.153350201471685 4050 5757843 SGTC_1862 st057513 3.81 µM -1.02354681577705 0.167991981617393 no 2805 0.15302468832905 4096 5393163 SGTC_813 k007-0158 173 µM -1.02565074596801 0.1674761949596 no 2806 0.152528119283086 4101 6523916 SGTC_1916 st067606 49.2 µM -1.02627116288086 0.167324292346571 no 2807 0.152381893012612 4063 19590279 SGTC_2742 clothiapine 36.27 µM -1.02637536363036 0.167298788591108 no 2808 0.152357343031898 4098 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2480 5767542 37.17 µM -1.03043601393109 0.166306871680749 no 2809 0.151402687297083 4074 2867358 SGTC_2708 st078559 56 µM -1.03111665507448 0.166140980223629 no 2810 0.151243059193998 4064 17250902 SGTC_681 1642-0006 26.6 µM -1.03172963282014 0.165991671766519 no 2811 0.151099395767449 4142 4446530 SGTC_327 1273-0057 3.96 µM -1.03394633777416 0.165452453173843 no 2812 0.150580625341628 3990 3108138 SGTC_2127 5253358 187.912 µM -1.0342263841829 0.165384411948998 no 2813 0.150515171217583 4027 20612 SGTC_1285 0929-0069 65.5 µM -1.03478985407035 0.165247563859465 no 2814 0.150383531097394 4148 1206237 SGTC_797 k781-0471 270 µM -1.03484278791963 0.165234711755162 no 2815 0.15037116841977 4096 23738129 SGTC_1974 st069448 26.9 µM -1.03512744954782 0.165165608265772 no 2816 0.150304697432257 4103 6323587 YNR016C ACC1 SGTC_1064 honokiol 6.76 µM -1.03620127376068 0.16490509875618 no 2817 0.150054126329955 4142 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3355 9151058 44.0485 µM -1.04075134517589 0.163804206864272 no 2818 0.148995483286574 4120 17015728 SGTC_2441 5730946 39.09 µM -1.04491097076598 0.162801966963974 no 2819 0.148032059422395 4195 1774275 SGTC_151 3013-0144 2.285 µM -1.04554301226635 0.162650029643471 no 2820 0.147886036035431 4019 906558 YHR107C CDC12 SGTC_702 1488-0190 94 µM -1.04555634078306 0.162646826576561 no 2821 0.147882957726932 4176 949357 SGTC_1340 1486-1359 257 µM -1.04715473541856 0.162263002977262 no 2822 0.14751410901229 4063 4309068 SGTC_1121 fusaric acid 630.51 nM -1.04830204460659 0.161987862675843 no 2823 0.147249733965785 4097 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_646 4092-0839 27.3 µM -1.0488270006766 0.161862072486955 no 2824 0.14712887403578 4170 877796 SGTC_1735 st034310 56.75 µM -1.05094380945484 0.161355487820989 no 2825 0.146642198940821 4202 871153 SGTC_3321 9137793 26.8275 µM -1.05164941540662 0.1611868555792 no 2826 0.146480213554212 4113 4904192 SGTC_303 1348-1668 34.2 µM -1.05180877748627 0.161148785676741 no 2827 0.146443645564325 4154 5380509 SGTC_1934 st074720 32.6 µM -1.0533992962784 0.16076914918698 no 2828 0.146079013291037 4099 17250992 SGTC_2863 9028737 58.44 µM -1.053434786335 0.160760684830481 no 2829 0.146070884027798 4116 6460917 SGTC_3124 9127567 49.47 µM -1.05599677363694 0.160150421181073 no 2830 0.145484844444608 4142 17592030 SGTC_441 propafenone 146 µM -1.0560581135907 0.160135828634098 no 2831 0.145470832699825 4133 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_558 k064-0027 21.3 µM -1.05789176393025 0.159700011441234 no 2832 0.145052395234626 4161 5088526 SGTC_2048 5246248 200 µM -1.05837131504572 0.159586161140874 no 2833 0.144943095848281 4176 677046 SGTC_2685 mycophenolic acid 18.85 µM -1.05875305465072 0.159495570268097 no 2834 0.144856129326995 4122 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1250 0485-0349 40.2 µM -1.05882623615311 0.159478207364365 no 2835 0.1448394613989 4157 6842794 YDL195W SEC31 SGTC_1803 st050068 52.4 µM -1.05940229547396 0.159341575834042 no 2836 0.144708302363518 4203 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_847 0342-0274 5.54 µM -1.05940350632201 0.159341288722107 no 2837 0.144708026758024 4158 18097 SGTC_3265 9137266 49.47 µM -1.06369770500663 0.158325194660266 no 2838 0.143732832229284 4087 17224265 SGTC_2780 5215298 71.43 µM -1.06401410479529 0.15825049661173 no 2839 0.143661154983649 4193 2834131 SGTC_2096 5468907 200 µM -1.06687021626708 0.15757725103938 no 2840 0.143015222898145 4176 759785 SGTC_2994 9053520 71.4286 µM -1.067804412125 0.157357450471574 no 2841 0.14280437371313 4209 4647384 SGTC_299 1273-0059 1.44 µM -1.07111647082616 0.156579803439908 no 2842 0.142058531584726 4011 2848077 SGTC_3034 9090421 49.47 µM -1.07279552672184 0.156186541533704 no 2843 0.141681434150516 4063 17173761 SGTC_1863 st057641 20.1 µM -1.07338120462934 0.156049519561675 no 2844 0.141550057007504 4184 3921635 SGTC_1048 3161-0300 24.5 µM -1.07483973367811 0.155708634550204 no 2845 0.141223243878556 4158 2165101 SGTC_2485 5633444 17.78 µM -1.07484308800331 0.155707851149245 no 2846 0.141222492863775 4174 5724239 SGTC_575 k072-0246 11.9 µM -1.07509333255538 0.155649413990514 no 2847 0.141166472134456 4258 6796779 SGTC_1746 st038117 42 µM -1.07688863594847 0.155230598555127 no 2848 0.140765010289853 4221 2898218 SGTC_2439 5492030 7.2 µM -1.07748081528625 0.155092615929894 no 2849 0.140632758510246 4169 5722370 SGTC_1702 st027038 51 µM -1.08365225770208 0.153659440215722 no 2850 0.139259505613831 4207 5521182 SGTC_3032 9089427 49.47 µM -1.084044265892 0.153568702448947 no 2851 0.139172586264212 4186 17173707 SGTC_3202 9113761 49.47 µM -1.08485591100946 0.153380944526721 no 2852 0.138992738871752 4167 4798415 SGTC_2489 cantharidin 73.42 µM -1.08591140885659 0.153137003696503 no 2853 0.138759094435148 4136 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3017 9080681 49.47 µM -1.08842015225877 0.15255822920835 no 2854 0.138204834337184 4201 16451914 SGTC_1425 4048-4433 7.33 µM -1.08883856742858 0.152461841000995 no 2855 0.138112540377662 4233 23734946 SGTC_3144 9087057 49.47 µM -1.08964060341615 0.152277192991516 no 2856 0.137935744910136 4087 17249618 SGTC_404 fumagillin 50 µM -1.09017644822426 0.152153911366379 no 2857 0.137817712912543 4183 12015870 A methionine aminopeptidase binder. SGTC_2085 5307070 144.047 µM -1.09261078974184 0.151594677927656 no 2858 0.137282361662734 4128 2840351 SGTC_2359 9039622 200 µM -1.09400531958552 0.15127493339327 no 2859 0.136976322572622 4138 6463596 SGTC_1199 1638-0010 4.46 µM -1.09424358177751 0.151220348388873 no 2860 0.136924080977197 4167 3111136 SGTC_1268 0828-0275 2.46 µM -1.09455454910412 0.151149126613387 no 2861 0.136855918470542 4236 745337 SGTC_2770 toltrazuril 17.5 µM -1.09611510615887 0.150792044633825 no 2862 0.136514202321927 4120 68591 Kills coccidiodes. SGTC_2419 paclitaxel 166.5 µM -1.09633929425763 0.150740792761119 no 2863 0.136465159695056 4118 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_256 clotrimazole 625 nM -1.09881362851525 0.150175903133348 no 2864 0.135924683211898 4123 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1382 3002-2117 298 µM -1.09885628785575 0.150166176410466 no 2865 0.13591537787042 4269 1497314 SGTC_140 0062-0056 502.533 µM -1.10006872823116 0.149889904399456 no 2866 0.135651088917571 4121 3758964 SGTC_390 dec-rvkr-cmk 16.7 µM -1.10061691294299 0.149765103963451 no 2867 0.135531710717708 4236 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_937 3122-0005 46.7 µM -1.10089528698705 0.149701755515536 no 2868 0.135471116761034 4212 759535 SGTC_413 propylparaben 100 µM -1.10118776537748 0.149635216660058 no 2869 0.135407472698893 4153 7175 A pharmaceutical preservative. SGTC_2030 5175110 200 µM -1.10121804007113 0.14962833029223 no 2870 0.135400886016965 4187 2831986 SGTC_2473 5854593 8.94 µM -1.10210283843035 0.149427164943264 no 2871 0.135208482774963 4079 2872951 SGTC_115 0527-0192 112.043 µM -1.10517322604424 0.148730490717447 no 2872 0.134542267941999 4181 4233931 SGTC_1769 st044406 64.4 µM -1.10562097567261 0.14862907752612 no 2873 0.134445303502877 4170 670903 SGTC_2965 9082772 38.63 µM -1.1083884862742 0.148003275439196 no 2874 0.133847037607115 4215 16459634 SGTC_867 0518-0118 155 µM -1.10851251291067 0.147975271322602 no 2875 0.133820269087264 4176 6848158 SGTC_1506 4226-2149 212 µM -1.11109669897731 0.147392591805182 no 2876 0.133263364309877 4207 991114 SGTC_3126 9127922 49.47 µM -1.11502879130944 0.1465089411154 no 2877 0.132419042049667 4252 45595682 SGTC_3236 9132701 49.47 µM -1.11610841088575 0.146266944020541 no 2878 0.132187866161668 4200 24282524 SGTC_2408 sulbentine 18.36 µM -1.11683213253818 0.14610487193181 no 2879 0.132033053554597 4128 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_731 3966-0296 387 µM -1.11958643360876 0.145489170172747 no 2880 0.131445019689422 4207 660956 SGTC_792 4534-1957 155 µM -1.1199950907834 0.145397967038355 no 2881 0.131357927048199 4165 1717904 SGTC_2463 5473429 200 µM -1.1208008005453 0.145218263332241 no 2882 0.131186331666051 4194 5399405 SGTC_661 1304-0007 33.6 µM -1.12449484159915 0.144396266589685 no 2883 0.13040157881868 4212 3117130 SGTC_2809 7964133 12.99 µM -1.12537149603519 0.144201655019873 no 2884 0.130215822250507 4220 1253665 SGTC_493 zm226600 134 µM -1.12572736055871 0.144122705898437 no 2885 0.130140469470653 4254 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2976 9009005 19.48 µM -1.12772601159913 0.143679843488399 no 2886 0.129717824399608 4260 2993148 SGTC_3152 9099253 49.47 µM -1.12879086445273 0.143444268063729 no 2887 0.129493033680701 4131 25236131 SGTC_1235 benzylparaben 21.5 µM -1.13068026607669 0.143026921391052 no 2888 0.129094845089206 4251 7180 SGTC_2009 4012297 12.05 µM -1.13214825389679 0.142703226990241 no 2889 0.128786055442433 4211 45595307 SGTC_1038 k292-0204 154 µM -1.14147238022617 0.140658805518144 no 2890 0.126836699665476 4184 4454212 SGTC_3246 9135460 32.98 µM -1.1426299992519 0.140406378425443 no 2891 0.126596122321488 4204 41446951 SGTC_93 0109-0045 59.227 µM -1.14265646161443 0.140400611716692 no 2892 0.126590626609594 4357 88733 SGTC_1830 st055982 50.3 µM -1.14270820142419 0.140389336981935 no 2893 0.126579881749479 4198 455313 An antimicrobial agent. SGTC_1494 4358-1428 177 µM -1.1435164731235 0.140213284552341 no 2894 0.12641210959579 4254 1564571 SGTC_834 0312-0008 75.7 µM -1.14493173743181 0.139905382288248 no 2895 0.126118717867116 4250 6385573 YIL048W NEO1 SGTC_519 k048-0011 62.8 µM -1.14660031316567 0.139542960735095 no 2896 0.12577342349758 4272 6836379 SGTC_3090 9117696 49.47 µM -1.1486193152946 0.139105279542887 no 2897 0.125356494452957 4201 7923821 SGTC_2831 7999036 19.48 µM -1.14951922413536 0.138910497830335 no 2898 0.12517097219674 4261 2988270 SGTC_892 0929-0076 29 µM -1.15054939110847 0.138687750337438 no 2899 0.124958831821139 4215 5751038 SGTC_691 1548-0686 185 µM -1.15189456272141 0.138397257537522 no 2900 0.124682201413055 4222 46495133 SGTC_1291 0993-0025 5.79 µM -1.15425587084281 0.137888331320988 no 2901 0.124197641371334 4232 4353356 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.15711631163551 0.137273540413434 no 2902 0.123612421616648 4273 6708760 SGTC_2508 celastrol 40.54 µM -1.16577110312169 0.13542479096769 no 2903 0.12185350174775 4193 122724 Celastrol is a natural product and antioxidant. SGTC_3136 9095672 49.47 µM -1.16674091609785 0.135218697474675 no 2904 0.121657506936483 4021 17217380 SGTC_2748 diazoxide 86.69 µM -1.1670635769242 0.135150177004804 no 2905 0.121592347786394 4325 3019 A potassium channel activatior. SGTC_3096 9117468 49.47 µM -1.16802713973536 0.134945695883657 no 2906 0.121397908866867 4160 41316311 SGTC_145 3737-0113 38.366 µM -1.1685337131809 0.134838279268278 no 2907 0.121295774301466 4214 6849351 SGTC_2624 nerol 100 µM -1.16883999198284 0.13477336269197 no 2908 0.121234052155695 4164 637566 A natural product oil. SGTC_2977 9011197 71.43 µM -1.1700572871537 0.134515565871742 no 2909 0.12098895785617 4324 2704722 SGTC_3270 9137563 49.47 µM -1.1705244579954 0.134416719124219 no 2910 0.120894988744804 4241 17015724 SGTC_454 lyso-paf C-16 6.67 µM -1.17100034924264 0.134316078551061 no 2911 0.120799318385689 4283 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_601 0986-0029 62.9 µM -1.17505597091556 0.133460502996252 no 2912 0.119986161991909 4206 24747981 SGTC_3042 9091578 49.47 µM -1.17625257291496 0.133208785088762 no 2913 0.119746980855472 4254 25236497 SGTC_3339 9145883 14.936 µM -1.17662521300755 0.133130463051622 no 2914 0.11967256490632 4175 2030670 SGTC_1398 3558-0053 112 µM -1.17730577879154 0.132987502555936 no 2915 0.119536740615322 4204 4532369 SGTC_428 3448-4153 16.5 µM -1.17756039140577 0.132934045488065 no 2916 0.119485954125893 4235 3834874 SGTC_500 h-89 112 µM -1.18116411705814 0.132179013392451 no 2917 0.118768766486035 4269 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1868 st057644 42.7 µM -1.18127735187989 0.132155337083318 no 2918 0.118746280686315 4292 688665 SGTC_2149 5554786 194.827 µM -1.18159404646672 0.132089134825057 no 2919 0.118683408481339 4304 745063 YPR165W RHO1 SGTC_2934 9036370 36.88 µM -1.18163319229452 0.132080953317374 no 2920 0.118675638638471 4251 6462800 SGTC_1412 3909-8563 178 µM -1.18364383423135 0.131661197481319 no 2921 0.118277040423694 4350 23767530 SGTC_716 1683-5115 658 µM -1.18713372337133 0.130934811086793 no 2922 0.117587439096739 4251 723597 SGTC_2523 spermine 47.74 µM -1.18811853373458 0.130730334351022 no 2923 0.117393356723982 4305 1103 A DNA binding polyamine. SGTC_354 2783-3500 4.88 µM -1.18990917415738 0.130359108472608 no 2924 0.117041046127612 4285 6740761 SGTC_971 1315-0384 26.7 µM -1.19406268038197 0.129500835380071 no 2925 0.116226725097773 4306 6769120 SGTC_114 0364-0001 490.298 µM -1.19430721670372 0.129450427150849 no 2926 0.11617890784671 4314 4003655 SGTC_539 4859-0462 2.54 µM -1.19794961364717 0.128701199908551 no 2927 0.115468316605955 4304 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2650 prasterone 100 µM -1.19895532595947 0.128494859819173 no 2928 0.115272658522854 4278 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_376 3970-0862 59.1 µM -1.19954605701093 0.128373767751717 no 2929 0.115157843630156 4321 3135186 SGTC_2887 9044784 58.44 µM -1.20299946461272 0.127667450227031 no 2930 0.114488263866453 4244 6465546 SGTC_2899 9053889 58.44 µM -1.20690026145791 0.126872883661344 no 2931 0.113735278497238 4275 6470052 SGTC_217 ketoconazole 989 nM -1.20843500539268 0.126561212123697 no 2932 0.113439990901055 4111 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1311 1190-0148 100 µM -1.20859572962869 0.126528603568126 no 2933 0.113409098913521 4347 1961333 SGTC_1748 st037455 53.6035 µM -1.20938187061386 0.126369191584657 no 2934 0.113258085197681 4335 580690 SGTC_2644 guaiazulene 100 µM -1.20944350869197 0.126356698666365 no 2935 0.113246250901516 4307 3515 A coloring agent. SGTC_518 1021-0119 62.6 µM -1.211405014166 0.125959586547693 no 2936 0.112870109307844 4271 1097762 SGTC_2664 lyso-paf C-16 73.48 µM -1.21325335214932 0.125586182666064 no 2937 0.1125164858614 4256 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2716 st080858 38.6235 µM -1.21326636248667 0.125583557039622 no 2938 0.112513999535825 4266 5296050 SGTC_1496 4469-0713 57.4 µM -1.21604559417959 0.125023555931167 no 2939 0.11198377697421 4280 746691 SGTC_580 1123-0028 41 µM -1.21674325795501 0.124883254519195 no 2940 0.111850957473859 4339 1677248 YPR107C YTH1 SGTC_3125 9127534 49.47 µM -1.2171888415658 0.124793704456602 no 2941 0.11176618734765 4181 1639235 SGTC_3209 9113616 49.47 µM -1.21773947478029 0.124683104309659 no 2942 0.111661495536767 4350 16649353 SGTC_2235 salicylic acid 500 µM -1.21948712224774 0.12433252582513 no 2943 0.111329680332243 4329 338 A COX inhibitor and kinase inhibitor. SGTC_1665 st014639 11.4 µM -1.2205067441078 0.124128308172165 no 2944 0.111136417257641 4369 981133 YIL048W NEO1 SGTC_2537 larixol 68.93 µM -1.22115806879053 0.123997978789897 no 2945 0.111013088470459 4279 6708759 SGTC_1375 2910-0797 186 µM -1.22121930056198 0.123985731303223 no 2946 0.111001499234169 4301 742508 SGTC_660 4031-1742 102 µM -1.22399424264159 0.123431579874305 no 2947 0.110477199716143 4189 6738706 SGTC_2898 9056270 58.44 µM -1.22853567098826 0.122528411635766 no 2948 0.109622973641744 4303 19154699 SGTC_2052 5265182 7.135 µM -1.23346171422563 0.121554007726186 no 2949 0.108701776142488 4315 1239884 SGTC_2851 9015922 71.43 µM -1.23383984742163 0.121479436210674 no 2950 0.108631293896419 4335 2996893 SGTC_1185 1319-0113 81.3 µM -1.23510165168644 0.121230828965405 no 2951 0.108396337390064 4377 4672763 SGTC_1217 1183-1422 255 µM -1.23654393746115 0.120947100818886 no 2952 0.108128222119972 4344 2849664 SGTC_2207 7258803 200 µM -1.23925583796879 0.120414878537713 no 2953 0.107625383880762 4319 3666799 SGTC_977 1348-1378 135 µM -1.23982474742444 0.120303437219694 no 2954 0.107520111331122 4309 X977 SGTC_3073 9114972 49.47 µM -1.24146906539924 0.119981747121669 no 2955 0.107216259517737 4317 41905075 SGTC_1966 st070145 16.1 µM -1.24230272585579 0.119818883787003 no 2956 0.107062445009166 4300 3748532 SGTC_380 3970-0968 6 µM -1.24469439903122 0.119352513401634 no 2957 0.106622052791785 4195 2891601 SGTC_289 k017-0060 526 µM -1.24491118993492 0.119310303114566 no 2958 0.106582198592344 4309 5512909 SGTC_2703 st077852 53.4 µM -1.24914121129849 0.118488804064105 no 2959 0.105806714840438 4353 6281836 SGTC_1281 0884-0031 11.8 µM -1.24933796463575 0.118450690759738 no 2960 0.105770743858983 4341 1548255 SGTC_538 2922-0838 53.3 µM -1.2572223387092 0.116930525503895 no 2961 0.104336568227865 4341 777039 SGTC_2796 7949634 45.45 µM -1.25775378747005 0.116828557982672 no 2962 0.104240406624212 4308 2971588 SGTC_1356 1502-0781 85.8 µM -1.26045318102836 0.116311606397502 no 2963 0.103752963667745 4333 567702 SGTC_3306 9127676 59.7925 µM -1.26072320040452 0.116259985347547 no 2964 0.10370429604904 4299 41905287 SGTC_814 3342-0569 96 µM -1.26269383563108 0.115883740685739 no 2965 0.103349615121328 4380 4346283 SGTC_3048 9093155 49.47 µM -1.26278572474821 0.115866217824994 no 2966 0.103333098153722 4303 25236002 SGTC_2316 5844804 197.44 µM -1.26332451202057 0.115763511259681 no 2967 0.103236290294623 4337 776813 SGTC_2084 5306078 60.6385 µM -1.26346170688353 0.115737368759022 no 2968 0.103211650010602 4279 679340 SGTC_2393 9031399 185.94 µM -1.26431740505898 0.115574409982172 no 2969 0.103058062455592 4350 1526623 YDL150W RPC53 SGTC_400 oxethazaine 37.5 µM -1.2649720423011 0.115449851264006 no 2970 0.102940675053705 4360 4621 A local anesthetic. SGTC_197 4544-0043 41.561 µM -1.26614935259925 0.115226082935861 no 2971 0.10272980812405 4356 896523 SGTC_1050 3232-1156 69.3 µM -1.26842120402029 0.114795149920362 no 2972 0.102323786674 4315 700529 SGTC_3215 9129942 49.47 µM -1.27033637258816 0.114432765494159 no 2973 0.101982418621228 4326 17682944 SGTC_3071 9117417 49.47 µM -1.27394618822067 0.113751938979888 no 2974 0.10134124385719 4284 45595590 YGL055W OLE1 SGTC_3043 9092303 49.47 µM -1.27860729721626 0.112877111631652 no 2975 0.100517689500146 4370 25236084 SGTC_2662 daunorubicin 22.37 µM -1.28736703508439 0.111246043461364 no 2976 0.0989831942819524 4247 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2918 7977171 22.06 µM -1.28746407010938 0.111228070475454 no 2977 0.0989662925844596 4350 2236483 SGTC_1343 1487-0095 224 µM -1.29023299622742 0.110716081255322 no 2978 0.0984848864596088 4358 4560101 YGL055W OLE1 SGTC_2017 5132927 60.65 µM -1.29074632156278 0.110621350524741 no 2979 0.0983958283102113 4341 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2000 st075254 36.4 µM -1.29167763671004 0.110449630927746 no 2980 0.0982344026017323 4253 17234175 SGTC_2198 6589944 200 µM -1.29305351592539 0.110196290695034 no 2981 0.0979962753115657 4358 5290268 SGTC_2879 9041815 71.43 µM -1.29327922522409 0.110154770736045 no 2982 0.0979572515894884 4387 4942971 SGTC_845 0330-0138 4.51 µM -1.29424726447104 0.109976824044308 no 2983 0.0977900128353243 4306 9039800 SGTC_1437 4092-1038 11.6 µM -1.29753718344864 0.109373607207237 no 2984 0.0972232099141006 4422 3977136 SGTC_2322 7413319 38.22 µM -1.29805020588575 0.109279757562988 no 2985 0.097135041673119 4338 1840400 SGTC_1461 k072-0203 53.8 µM -1.29861411476023 0.10917666578213 no 2986 0.0970381957838162 4274 5418714 SGTC_2262 9014885 67.46 µM -1.29899080221867 0.109107840086754 no 2987 0.0969735428568202 4372 6457424 SGTC_1305 1181-0477 144 µM -1.30207061076822 0.108546288447485 no 2988 0.0964461243333358 4422 6252086 SGTC_627 1391-0720 175 µM -1.30229050130885 0.10850627474656 no 2989 0.0964085487579727 4338 997839 SGTC_2847 9005661 71.43 µM -1.30273250018813 0.108425875874857 no 2990 0.0963330511695607 4411 2991449 SGTC_545 4218-0007 221 µM -1.30343403657315 0.108298355576913 no 2991 0.0962133113468836 4356 2840508 SGTC_1176 0848-0131 83.3 µM -1.30443689214692 0.108116251102117 no 2992 0.096042331715982 4422 6769040 SGTC_1419 3993-2473 62.6 µM -1.3061068182683 0.107813505334794 no 2993 0.0957581173093372 4435 704026 SGTC_1655 st012546 55.1 µM -1.31062321073399 0.106997775511722 no 2994 0.0949925467436833 4361 720985 YLR208W SEC13 SGTC_1332 1480-0653 17.5 µM -1.31195837265359 0.106757479554035 no 2995 0.0947670901611795 4373 5749438 SGTC_2828 7998861 71.43 µM -1.31333839411102 0.106509519527477 no 2996 0.0945344732454784 4372 2988188 SGTC_891 0929-0073 133 µM -1.31345084666552 0.106489332570067 no 2997 0.094515536766857 4405 5603632 SGTC_3049 9092223 49.47 µM -1.31441876541958 0.106315690520797 no 2998 0.0943526594418915 4362 8623917 SGTC_156 3474-0145 5.642 µM -1.31451718935662 0.106298044988687 no 2999 0.0943361086744409 4288 2265471 SGTC_1724 st037281 8.293 µM -1.31582943645731 0.106062986211378 no 3000 0.0941156484284429 4344 574124 YDL195W SEC31 SGTC_1275 0867-0008 21.1 µM -1.32289038737312 0.104804625511999 no 3001 0.0929359162444519 4363 3422836 SGTC_3024 9090631 49.47 µM -1.32543500291402 0.104353799735311 no 3002 0.092513456948358 4338 25236383 SGTC_1428 4049-0204 61.7 µM -1.32799102889615 0.103902368888839 no 3003 0.0920905352967792 4421 X1428 SGTC_1902 st060212 70.5 µM -1.32961026887435 0.103617121692775 no 3004 0.0918233564861206 4392 688944 SGTC_1677 st019204 53.9 µM -1.32971054984718 0.103599474783907 no 3005 0.0918068287649943 4397 3945625 SGTC_1623 st003709 20.3 µM -1.33147945478949 0.103288550811296 no 3006 0.091515650406677 4358 16192618 SGTC_1324 1418-0026 34.4 µM -1.33783020567315 0.102177849828156 no 3007 0.0904758964790024 4429 1372513 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.33945891040518 0.101894406021829 no 3008 0.0902106612038338 4429 5393153 SGTC_2474 5321570 43.32 µM -1.34213118743343 0.101430589607143 no 3009 0.0897767316380647 4383 2841384 SGTC_2933 9026794 32.47 µM -1.34521966554666 0.100896452877666 no 3010 0.0892771536642604 4333 17586027 SGTC_2886 9058944 51.95 µM -1.34537560952348 0.100869537644166 no 3011 0.0892519838502281 4324 4949929 SGTC_848 0368-0089 85.6 µM -1.34714981036095 0.100563687033151 no 3012 0.0889659942923118 4378 762535 SGTC_2328 6201408 200 µM -1.34749237796574 0.100504710558437 no 3013 0.0889108532984434 4376 2890418 SGTC_2345 9052315 157.45 µM -1.34766700858091 0.100474655845958 no 3014 0.0888827538787238 4415 6469265 SGTC_1162 k048-0130 20.1 µM -1.35002002105476 0.100070331122339 no 3015 0.0885047804374167 4369 6797406 SGTC_1476 4112-3294 3.34 µM -1.35009749876015 0.100057038143238 no 3016 0.0884923552909249 4403 704369 SGTC_1768 st044301 37.178 µM -1.35213745594046 0.0997075030374405 no 3017 0.088165673530372 4402 3931349 SGTC_2204 7233102 200 µM -1.35445864785994 0.0993108659978059 no 3018 0.0877950488394046 4346 2172480 SGTC_680 0417-1641 114 µM -1.35483162680603 0.0992472404015113 no 3019 0.0877356038271872 4422 2835990 SGTC_996 3970-0799 1.8 µM -1.35556096477467 0.0991229104988979 no 3020 0.087619449441693 4389 6615648 YGL040C HEM2 SGTC_2555 cholic acid 100 µM -1.35768738391274 0.0987610710860911 no 3021 0.0872814508468963 4353 6708657 Influences liver metabolism. SGTC_653 0203-0016 55.2 µM -1.35946563791809 0.0984592197063327 no 3022 0.0869995420012646 4469 295302 SGTC_1216 1165-0504 9.65 µM -1.36323285349644 0.0978219826589303 no 3023 0.0864045681119099 4430 6304004 SGTC_2771 fluoxetine 41.05 µM -1.36354491439502 0.0977693324197006 no 3024 0.086355419667198 4405 3386 A selective serotonin reuptake inhibitor. SGTC_2406 ethylparaben 405.7 µM -1.36509999474517 0.097507272308492 no 3025 0.086110811853152 4385 8434 A possible steroid mimic. SGTC_1931 st074438 57.1 µM -1.36637576935989 0.0972926654173623 no 3026 0.0859105250493546 4412 2787313 SGTC_408 cantharidin 100 µM -1.36674589671776 0.0972304686321596 no 3027 0.0858524831952139 4383 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1874 staurosporine 7.6 µM -1.3679004896972 0.0970366364718824 no 3028 0.0856716132352441 4418 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_666 0272-0154 136 µM -1.36969929362332 0.0967352200906194 no 3029 0.0853903946499921 4408 6870312 SGTC_1248 0469-0687 58.6 µM -1.37339940570205 0.0961173741695904 no 3030 0.0848141072181251 4384 4017482 SGTC_1672 st016598 6.51 µM -1.37460526989992 0.09591664673529 no 3031 0.0846269269648228 4382 4665860 YNL267W PIK1 SGTC_2571 chrysanthemic acid 100 µM -1.37705040671342 0.0955105774037227 no 3032 0.0842483320051255 4399 2743 An insecticide. SGTC_877 0771-0151 33.1 µM -1.37827082908784 0.0953083731217281 no 3033 0.0840598430484659 4431 6166523 SGTC_3139 9095020 49.47 µM -1.38189470898665 0.0947098123698941 no 3034 0.0835020163916739 4276 25236292 SGTC_226 1,3-diallylurea 8.28947 mM -1.38248927588281 0.0946118721633835 no 3035 0.0834107605176623 4384 74537 YKL182W FAS1 SGTC_2514 salinomycin 42.74 µM -1.38353553834778 0.0944397075846639 no 3036 0.0832503591238515 4464 23682228 A polyether potassium ionophore. SGTC_3160 9100216 49.47 µM -1.38445985743223 0.0942878013157628 no 3037 0.0831088457783669 4397 17191039 SGTC_2741 miltefosine 3.04 µM -1.3878890351236 0.0937258110875133 no 3038 0.082585418612295 4472 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_744 1594-0068 283 µM -1.3932274683592 0.0928558503676035 no 3039 0.0817755079589687 4428 668392 SGTC_2292 7671323 168.05 µM -1.3943687124343 0.092670648274894 no 3040 0.081603145565368 4457 937504 SGTC_472 calcifediol 10 µM -1.39563498831578 0.0924654758172378 no 3041 0.0814122203242724 4467 5283731 A vitamin D metabolite. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.3964791571187 0.0923288834666541 no 3042 0.0812851264097141 4336 17037758 SGTC_1325 1431-0015 227 µM -1.39711661657511 0.0922258371172469 no 3043 0.0811892528735141 4447 1103340 SGTC_2896 9052656 71.43 µM -1.40629110265822 0.0907521835588991 no 3044 0.0798188505343309 4157 6469436 SGTC_278 4092-0821 23.9 µM -1.40786367993731 0.0905013521964351 no 3045 0.0795857198189048 4436 877900 SGTC_2110 5483698 200 µM -1.40901297649094 0.0903183613317309 no 3046 0.0794156655524676 4424 2848765 YHR062C RPP1 SGTC_2338 7999974 200 µM -1.41031671682514 0.0901111127654102 no 3047 0.0792230922950784 4442 315925 SGTC_1191 1487-1166 10.6 µM -1.41223412568766 0.0898069548271523 no 3048 0.0789405177296515 4467 3955771 SGTC_3336 9143619 71.43 µM -1.41373722257947 0.0895690531650507 no 3049 0.0787195359714045 4455 45595730 SGTC_887 0885-0007 9.62 µM -1.41381471471099 0.0895568008648038 no 3050 0.0787081559805548 4468 5719458 SGTC_347 4534-1311 26.2 µM -1.41812856278107 0.0888767016017255 no 3051 0.0780766167809742 4456 2862016 SGTC_2396 5342950 42.78 µM -1.42193544531119 0.0882797284333638 no 3052 0.0775224960804699 4438 1886677 SGTC_2150 5556613 200 µM -1.42521904949683 0.0877672176375581 no 3053 0.077046945726386 4481 743190 SGTC_453 enantio-paf c16 10 µM -1.42713215967498 0.0874696410733548 no 3054 0.0767709021443622 4113 13871343 A lipid and platelet activating factor SGTC_3119 9125183 49.47 µM -1.42749105938108 0.0874138996556161 no 3055 0.0767192002079152 4306 22695334 SGTC_2093 5331342 194.4 µM -1.4285277074379 0.0872530447103594 no 3056 0.0765700127117343 4489 33839 SGTC_1131 3454-3128 32.3 µM -1.43289998539362 0.0865770368877419 no 3057 0.0759432107318705 4452 710982 SGTC_1800 st050079 29.0735 µM -1.43712117276855 0.0859281113711021 no 3058 0.07534178304425 4273 3645560 SGTC_1022 4477-0945 21.3 µM -1.44149184076554 0.085260048783067 no 3059 0.0747228903862744 4406 4648966 SGTC_87 0100-0052 35.5 µM -1.44411118495344 0.0848615476484138 no 3060 0.0743538511651415 4481 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1376 2910-0861 41.3 µM -1.4461482177808 0.0845526045820267 no 3061 0.074067817000713 4416 1112859 SGTC_1658 st012944 20 µM -1.44772307095035 0.0843143360542134 no 3062 0.0738472574959012 4299 24207260 SGTC_3230 9131665 49.47 µM -1.45013651801168 0.083950170165803 no 3063 0.0735102267098634 4474 15943720 SGTC_1633 st005664 67.9 µM -1.45138394656964 0.0837624088464793 no 3064 0.0733364887006331 4446 2063822 SGTC_541 4513-1321 94 µM -1.45139684639751 0.0837604688304787 no 3065 0.0733346936945808 4421 747515 SGTC_2504 purpurogallin 52.29 µM -1.45217825818651 0.0836430145888193 no 3066 0.0732260232111139 4400 5281571 An antioxidant. SGTC_3278 9139605 49.47 µM -1.45318752083961 0.0834914951986528 no 3067 0.0730858480176793 4454 7958859 SGTC_1597 7-benzyloxygramine 47.5 µM -1.45423091158203 0.0833350691519169 no 3068 0.0729411487905137 4372 260807 SGTC_363 0455-0021 3.06 µM -1.45925842230041 0.0825844274482719 no 3069 0.0722469971840165 4420 4597466 SGTC_2667 digitoxin 100 µM -1.46178642819619 0.0822089071954048 no 3070 0.0718998721725509 4434 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_96 0929-0093 37.281 µM -1.46392525385455 0.0818922029273454 no 3071 0.071607186197174 4476 6991579 SGTC_2967 9089538 49.85 µM -1.46597582591356 0.0815894308934863 no 3072 0.0713274363749205 4456 728216 SGTC_2391 6285546 200 µM -1.4676360593488 0.0813449122721265 no 3073 0.0711015538060454 4487 846083 SGTC_1096 rimcazole 32.2 µM -1.46769896960911 0.0813356577519283 no 3074 0.0710930053834695 4422 18528119 A dopamine reuptake inhibitor. SGTC_3168 9103419 49.47 µM -1.4691833866002 0.081117520482682 no 3075 0.0708915275834458 4510 16649256 SGTC_2914 7968218 45.32 µM -1.47008007809389 0.0809859644027629 no 3076 0.0707700336096737 4435 2977111 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.47764280050657 0.0798828163727164 no 3077 0.0697517059604434 4505 4174840 SGTC_3317 9138495 8.753 µM -1.48176667370891 0.079286088764637 no 3078 0.0692011947315601 4400 17020139 SGTC_839 0122-0028 230 µM -1.48516910326845 0.0787963002932159 no 3079 0.0687495171592863 4500 759448 SGTC_82 0054-0107 293.755 µM -1.48638563094278 0.0786217354944944 no 3080 0.0685885741600859 4456 3104697 SGTC_1405 3909-7894 12 µM -1.48705867407712 0.0785252836559349 no 3081 0.0684996574997353 4477 7104060 SGTC_2688 kanamycin b 96.69 µM -1.48850457390772 0.0783183793520197 no 3082 0.068308938408485 4472 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_772 k072-0172 35.3 µM -1.49109879262871 0.0779481904091067 no 3083 0.0679677796417964 4533 5861980 SGTC_2438 5259590 200 µM -1.49335670754623 0.0776270732538274 no 3084 0.0676719194665306 4500 1201127 SGTC_2045 5106652 78.05 µM -1.49651732897438 0.0771792628358056 no 3085 0.0672594477744286 4486 673349 SGTC_1841 st054148 70 µM -1.50086405722754 0.0765666092105774 no 3086 0.0666953631597014 4513 675442 SGTC_2640 pentamidine 10.38 µM -1.50167017472712 0.0764533979742215 no 3087 0.0665911550935099 4458 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1888 azatryptophan 97.5 µM -1.50420823410842 0.0760977842552506 no 3088 0.0662638791354418 4519 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_409 arachidonic acid 100 µM -1.50580442305199 0.0758747841336102 no 3089 0.0660586937821037 4507 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_583 1488-1091 88.9 µM -1.51187814278995 0.0750307857634388 no 3090 0.065282432688991 4598 4303273 SGTC_2398 5228213 48.84 µM -1.51654155344553 0.0743876364264658 no 3091 0.0646912357062726 4443 80771 YMR134W ERG29 SGTC_2891 9063876 19.48 µM -1.51789118351434 0.0742022912332877 no 3092 0.0645209164554392 4533 6472478 SGTC_2176 5809774 33.9695 µM -1.51911064244662 0.074035126003949 no 3093 0.0643673241725927 4417 2870539 SGTC_910 3454-3003 490 µM -1.52132598857556 0.0737321794063508 no 3094 0.0640890258036721 4419 820824 SGTC_3238 9133470 49.47 µM -1.52188654333046 0.0736556744696607 no 3095 0.064018755759287 4510 3534688 SGTC_3093 9117344 49.47 µM -1.52314844338707 0.0734836714930172 no 3096 0.0638607856803973 4524 24824913 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.52620135870441 0.0730688152350725 no 3097 0.0634798626026387 4470 279621 SGTC_3180 9109287 49.47 µM -1.53426093058208 0.0719822239611626 no 3098 0.0624827366067072 4536 18891271 SGTC_123 0083-0120 66.675 µM -1.53554365347955 0.0718104360612202 no 3099 0.062325171397727 4494 16001701 SGTC_501 nsc-95397 161 µM -1.53773228387189 0.0715180512318996 no 3100 0.0620570432979268 4515 262093 SGTC_1515 3460-0031 42.1 µM -1.54179281281662 0.0709780153674598 no 3101 0.0615619745775394 4489 2876596 SGTC_2329 6138490 200 µM -1.54194137465791 0.0709583167297162 no 3102 0.0615439202445298 4536 720019 SGTC_603 3794-0023 45.9 µM -1.54223506940686 0.0709193864723968 no 3103 0.0615082404557242 4551 3802260 SGTC_1749 st037932 54.2 µM -1.54404273009617 0.0706801359430221 no 3104 0.0612889906655156 4515 594497 SGTC_2341 7987486 176.74 µM -1.54512910026982 0.0705366495453879 no 3105 0.0611575197026701 4528 1258686 SGTC_11 0438-0307 1.3 µM -1.54955997237995 0.0699537436033422 no 3106 0.060623583287821 4518 4011476 SGTC_3251 9135047 49.47 µM -1.55472745126447 0.0692786230132709 no 3107 0.0600054969277552 4568 17682963 SGTC_485 niflumic acid 177 µM -1.55515692056168 0.0692227404246945 no 3108 0.0599543506800604 4558 4488 A COX2 inhibitor. SGTC_1415 3966-0071 78.1 µM -1.55549661482607 0.0691785639761632 no 3109 0.0599139200855945 4437 2893185 SGTC_889 0919-1524 82.7 µM -1.55696479712653 0.0689878800810888 no 3110 0.0597394217900871 4538 3905452 SGTC_1117 retinoic acid 1.10837 µM -1.56130154427407 0.0684269994068428 no 3111 0.0592263097069189 4558 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1492 4158-0558 28.5 µM -1.56784866561179 0.0675869197386483 no 3112 0.058458227194922 4537 3967268 SGTC_1165 k072-0275 30.3 µM -1.56990083843495 0.0673252466184443 no 3113 0.0582190912603808 4513 6153523 YGL055W OLE1 SGTC_882 0843-0131 351 µM -1.57243596930489 0.0670030734937254 no 3114 0.0579247389680215 4538 5425421 SGTC_2284 7945075 39.21 µM -1.57342056155782 0.0668782701104522 no 3115 0.0578107345204638 4492 1245402 SGTC_2617 dihydrotanshinone i 20.83 µM -1.57561651269388 0.0666005671236038 no 3116 0.0575571041422878 4476 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1360 1598-0022 39.8 µM -1.57788632974926 0.0663144618760178 no 3117 0.0572958630310974 4558 761525 SGTC_2775 cyproheptadine 69.59 µM -1.57864888720328 0.0662185571382181 no 3118 0.0572083073421425 4528 2913 A selective serotonin reuptake inhibitor. SGTC_2602 kawain 100 µM -1.58013995936679 0.0660313395580572 no 3119 0.0570374089903011 4501 5369129 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.58123602278332 0.0658939806188532 no 3120 0.0569120408405292 4596 368090 SGTC_2368 9071271 200 µM -1.58559771654414 0.0653495650281717 no 3121 0.0564152972849793 4522 27209959 SGTC_287 k060-0039 29.6 µM -1.58635516237166 0.0652553791404707 no 3122 0.0563293827614308 4583 5861974 SGTC_3086 9117350 49.47 µM -1.59092142868939 0.0646898085987974 no 3123 0.0558136296806875 4520 2679265 SGTC_3031 9088762 49.47 µM -1.59348372252826 0.0643741185108648 no 3124 0.0555258585345069 4522 205253 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.59429806500176 0.0642740376835377 no 3125 0.0554346454437865 4575 1609 A potent and irreversible inhibitor of serine proteases. SGTC_290 2043-6722 48.1 µM -1.59548991741521 0.0641277798064897 no 3126 0.0553013614474735 4563 773758 YLR208W SEC13 SGTC_1027 k015-0025 8.67 µM -1.59635175588778 0.0640221807922254 no 3127 0.0552051404384796 4515 3598955 SGTC_1253 0550-0034 176 µM -1.59827326630611 0.0637872295007634 no 3128 0.0549910871686716 4534 5969915 SGTC_1265 0819-1001 68.8 µM -1.6021882420663 0.0633106045519337 no 3129 0.0545569946677804 4485 3106768 SGTC_1350 1495-0454 146 µM -1.60646947543888 0.0627925686642651 no 3130 0.0540853982638023 4574 1069057 SGTC_293 4049-0273 38.5 µM -1.60944845409359 0.0624340606354701 no 3131 0.0537591587474565 4447 1380311 SGTC_164 4100-3994 89.624 µM -1.61026283898606 0.0623363310243712 no 3132 0.0536702440900139 4519 4615967 SGTC_2482 5981709 142.65 µM -1.61069879935315 0.0622840629966384 no 3133 0.0536226937669566 4491 877755 SGTC_2220 6782180 200 µM -1.61594906107731 0.0616572815177608 no 3134 0.0530526634982763 4508 833803 SGTC_865 0488-0499 301 µM -1.62202131076095 0.0609385242340027 no 3135 0.0523993926098924 4494 9634651 SGTC_2711 st079103 59.1 µM -1.62556793312208 0.0605217595479963 no 3136 0.0520208007191558 4488 54693780 SGTC_2002 4023503 131 µM -1.62680575812502 0.0603768284682073 no 3137 0.0518891791595921 4541 4736863 YCR052W RSC6 SGTC_3111 9122088 49.47 µM -1.62811668239709 0.0602236348294912 no 3138 0.0517500734295553 4498 16876704 SGTC_1402 3909-7673 35.9 µM -1.63200184285468 0.0597714046294542 no 3139 0.0513395489859974 4580 5328014 SGTC_1477 0139-0234 16 µM -1.63537567923614 0.0593808543395113 no 3140 0.0509851587943704 4577 620880 SGTC_2430 5571206 200 µM -1.63565121401462 0.0593490474146738 no 3141 0.0509563026423057 4539 1731771 SGTC_663 1486-0733 13.9 µM -1.63674853518323 0.0592225083933322 no 3142 0.0508415115688536 4572 722445 YPR165W RHO1 SGTC_2616 abietic acid 100 µM -1.64027969684477 0.0588167433799982 no 3143 0.0504735125521077 4589 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_407 eburnamonine 100 µM -1.64146114194651 0.0586814719420707 no 3144 0.0503508634647957 4421 3195 SGTC_2305 7443522 69.23 µM -1.6498283600722 0.0577304313929069 no 3145 0.0494890232635858 4473 5415886 SGTC_221 trifluoperazine 10.304 µM -1.65072822504643 0.0576288762750892 no 3146 0.0493970408845083 4559 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2642 cholecalciferol 100 µM -1.65309688167497 0.0573622308634244 no 3147 0.0491555739421712 4569 9821465 A vitamin D precursor, similar to steriods. SGTC_2670 beta-carotene 100 µM -1.65487005544034 0.0571632564912852 no 3148 0.0489754297955926 4563 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3201 9113999 49.47 µM -1.6586638104815 0.0567393699748661 no 3149 0.048591777845459 4542 16649224 SGTC_2082 5219693 150 µM -1.65996559834411 0.0565944896006548 no 3150 0.0484606867031618 4527 2834649 SGTC_2061 5245884 80.95 µM -1.6615697368509 0.0564163606696296 no 3151 0.0482995377410074 4550 573863 SGTC_952 1185-0122 232 µM -1.66391278315773 0.0561569753574665 no 3152 0.0480649300254488 4526 678600 SGTC_2983 9022671 12.99 µM -1.66431765382671 0.0561122498682927 no 3153 0.0480244831486585 4554 6405161 SGTC_2954 9074818 52.69 µM -1.66679724075302 0.0558389459477945 no 3154 0.0477773645496088 4571 16648742 SGTC_3164 9100705 49.47 µM -1.66996814832357 0.0554909751510921 no 3155 0.0474628328288354 4598 17174235 SGTC_2808 7946468 45.46 µM -1.67033128131576 0.0554512349549874 no 3156 0.0474269187071985 4545 2970879 SGTC_719 2810-4230 27.3 µM -1.67047131539869 0.0554359160455256 no 3157 0.0474130750514089 4594 721079 SGTC_2717 st081029 62.2815 µM -1.67061739634047 0.055419939206205 no 3158 0.0473986370587714 4554 5292846 SGTC_2995 9067767 71.4286 µM -1.67212272939571 0.0552555129609934 no 3159 0.0472500617225141 4556 11673567 SGTC_2252 omeprazole 400 µM -1.67414727977404 0.055034980895845 no 3160 0.0470508288564528 4606 4594 A proton pump inhibitor. SGTC_572 0960-0087 17.7 µM -1.67499800978711 0.0549425195692261 no 3161 0.0469673110742512 4533 6796365 SGTC_2552 juarezic acid 87.02 µM -1.67684056149972 0.0547426832868386 no 3162 0.0467868318469634 4535 1549512 SGTC_791 1348-1292 225 µM -1.6796403603777 0.054440127975106 no 3163 0.046513654993038 4549 5437054 SGTC_1403 3909-7815 62.9 µM -1.68118881913084 0.0542733654445593 no 3164 0.0463631222812451 4605 6615483 SGTC_2351 9026858 72.31 µM -1.68241868264773 0.0541412024962796 no 3165 0.0462438405560081 4483 1409300 SGTC_1257 0669-0121 16 µM -1.68551061778207 0.0538100635654767 no 3166 0.0459450490106937 4567 4307855 SGTC_1279 0874-0590 65.2 µM -1.68848402319809 0.0534931336414505 no 3167 0.0456591766709002 4652 3523074 SGTC_615 k087-0205 167 µM -1.69106036815133 0.0532197232467427 no 3168 0.045412636749835 4596 9642773 SGTC_2032 5185112 25.99 µM -1.69163432465615 0.0531589641966816 no 3169 0.0453578588301601 4468 5718189 SGTC_2156 5649887 115 µM -1.69994907925779 0.0522849191659481 no 3170 0.0445702520146537 4617 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_941 3237-0776 460 µM -1.70058364672746 0.0522186850669188 no 3171 0.0445105985480471 4579 760008 SGTC_875 0709-0210 25.7 µM -1.70324375548556 0.0519417563892648 no 3172 0.0442612306793835 4572 6251364 SGTC_3058 9093861 49.47 µM -1.70842099248108 0.0514061304991112 no 3173 0.0437791274065423 4599 17217477 SGTC_911 3456-4043 236 µM -1.70861491404664 0.0513861534671777 no 3174 0.0437611521091623 4569 914281 SGTC_2819 7996655 46.38 µM -1.71424894726627 0.0508084487835207 no 3175 0.0432415074469247 4570 6456960 SGTC_1526 st051518 75 µM -1.71498732535753 0.0507331214791351 no 3176 0.0431737753721109 4570 673993 SGTC_3297 9117502 71.43 µM -1.7155325469174 0.0506775565746963 no 3177 0.0431238167347379 4607 7453720 SGTC_863 0466-0191 129 µM -1.71858917421857 0.0503669449502374 no 3178 0.0428446021453633 4635 765160 YPR165W RHO1 SGTC_298 1391-0729 10 µM -1.72004111912447 0.0502199320912402 no 3179 0.0427124837304806 4563 3237558 SGTC_2122 5258151 111.688 µM -1.72273631889291 0.0499479436414142 no 3180 0.0424681096650993 4612 2173356 SGTC_768 0384-0033 77.3 µM -1.72723720600757 0.0494963529574396 no 3181 0.0420625356998601 4561 3965305 YMR134W ERG29 SGTC_2360 9040895 200 µM -1.73055993362147 0.049165066981588 no 3182 0.0417651414959811 4611 4914414 SGTC_2786 7743617 45.45 µM -1.74058094028282 0.0481766563542579 no 3183 0.0408785304773798 4533 583674 SGTC_1400 3771-8998 51.5 µM -1.74135476973506 0.0481009966323087 no 3184 0.0408107056383823 4577 670767 SGTC_3354 9151612 71.43 µM -1.75124877157093 0.0471419851685622 no 3185 0.0399515338686391 4588 27261949 SGTC_2935 9038016 29.96 µM -1.75140725632675 0.0471267491208908 no 3186 0.0399378919818066 4563 6463195 SGTC_2263 7948595 193.29 µM -1.75536408010462 0.0467476349857618 no 3187 0.0395985260142594 4627 2971371 SGTC_471 1-acyl-paf 4 µM -1.76112872950007 0.0461996912069127 no 3188 0.0391083087116799 4588 16759367 SGTC_3047 9092122 49.47 µM -1.76374266575449 0.0459529357702407 no 3189 0.038887657157366 4586 17173831 SGTC_2958 9077254 16.72 µM -1.76545420045031 0.0457919414329574 no 3190 0.0387437305296915 4611 16457351 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.7728375652486 0.0451026190897521 no 3191 0.0381278133686673 4599 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_998 3996-0085 177 µM -1.7869414784789 0.0438090790128316 no 3192 0.0369734738055228 4639 715391 SGTC_2778 tioconazole 65.09 nM -1.79124660517758 0.0434202510793206 no 3193 0.03662686517823 4516 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_274 sirtinol 40.1 µM -1.79175379334059 0.0433746271704546 no 3194 0.0365862067124968 4655 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1079 idarubicin 2.36 µM -1.79214127819172 0.0433397972122874 no 3195 0.0365551690852893 4642 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_39 0986-0283 58.349 µM -1.79869431085796 0.0427541760471421 no 3196 0.0360335246795173 4639 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2065 5221596 34.26 µM -1.8065963974097 0.0420565197389692 no 3197 0.0354126158199152 4593 788581 SGTC_1220 1838-0075 193 µM -1.81534700806261 0.0412947312652206 no 3198 0.0347352996014132 4562 5529645 SGTC_613 3914-0030 117 µM -1.81620830691399 0.041220359027081 no 3199 0.0346692121537724 4393 1145395 SGTC_864 0469-0573 172 µM -1.82263167992674 0.0406691263276319 no 3200 0.0341795970732686 4619 689425 SGTC_2861 9024595 19.48 µM -1.827153543442 0.0402846747637683 no 3201 0.0338383433012455 4607 16482810 SGTC_2386 9075165 157.42 µM -1.83509530403566 0.0396166092696818 no 3202 0.033245784808695 4618 16452277 SGTC_2107 5363541 170.161 µM -1.83883100184822 0.0393054907980484 no 3203 0.0329700234234336 4587 244052 SGTC_1215 3852-0577 11.2 µM -1.84480168353883 0.0388123678427284 no 3204 0.0325331962267225 4659 2884876 SGTC_1832 st054113 55 µM -1.84720901234858 0.0386149755784797 no 3205 0.03235842685831 4663 1251267 SGTC_1917 st066507 28.5 µM -1.84834652156504 0.0385219889256124 no 3206 0.0322761148906564 4564 3156428 SGTC_2445 5742597 35.57 µM -1.85052353142687 0.0383445362646501 no 3207 0.032119064835469 4648 1774255 SGTC_484 loperamide 105 µM -1.85315165874651 0.0381312005535128 no 3208 0.0319303121241881 4728 3955 An opioid-receptor agonist. SGTC_3284 9108171 64.8615 µM -1.85867617478854 0.0376859091862856 no 3209 0.0315365262596949 4613 8687505 SGTC_2866 9034245 58.44 µM -1.8598204655979 0.0375942089126337 no 3210 0.0314554654357008 4674 6462273 SGTC_920 mycophenolic acid 780.421 nM -1.86047665318142 0.0375417061123249 no 3211 0.0314090592910634 4621 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_694 1315-0438 43.2 µM -1.86508777311747 0.0371744481846636 no 3212 0.0310845510568439 4680 6793154 SGTC_2638 epoxomicin 18 µM -1.87120193664881 0.0366920112805007 no 3213 0.0306585482245071 4622 9915668 A protesome inhibitor. SGTC_2383 9036125 200 µM -1.87184834374765 0.0366413073439918 no 3214 0.0306137939113074 4610 79580 SGTC_206 4546-0025 72.014 µM -1.88829830235929 0.0353701497581874 no 3215 0.0294929575520922 4661 6620745 YIL048W NEO1 SGTC_195 4234-0266 16.654 µM -1.89212255679768 0.0350798742107509 no 3216 0.0292373267792488 4680 2303354 SGTC_331 k048-0133 24.5 µM -1.89430163239801 0.0349153501898172 no 3217 0.0290924922388993 4648 6813582 SGTC_72 0744-0168 198.391 µM -1.8952997785669 0.0348402002003395 no 3218 0.0290263487507546 4555 677577 SGTC_715 0868-0130 184 µM -1.9019354983833 0.0343439691249952 no 3219 0.0285897938222751 4698 2876258 SGTC_555 4296-0685 37 µM -1.90597836443829 0.0340444940845108 no 3220 0.0283265063738317 4647 2908540 YHR072W ERG7 SGTC_2004 4023728 41.89 µM -1.9170254024914 0.0332371209492762 no 3221 0.027617352269512 4607 360084 YDR527W RBA50 SGTC_784 4579-0127 173 µM -1.91920375502294 0.0330797923113199 no 3222 0.0274792762529014 4671 1948547 SGTC_2257 7960413 200 µM -1.91951963688684 0.0330570291830996 no 3223 0.0274593017798026 4695 2974689 YIL048W NEO1 SGTC_1984 st072354 53.1 µM -1.92224702866389 0.0328610237839393 no 3224 0.0272873409099813 4580 5762938 SGTC_74 000s-0487 160.283 µM -1.92444384029163 0.0327038462498152 no 3225 0.0271494868612718 4560 677548 SGTC_2172 5754775 163.918 µM -1.92450554553328 0.0326994403279702 no 3226 0.0271456231471577 4650 2263357 SGTC_946 3434-1334 87.4 µM -1.92716770385693 0.0325098205630897 no 3227 0.0269793667119452 4640 4047976 SGTC_1899 st063254 59.6 µM -1.92836076894193 0.032425135944822 no 3228 0.0269051339841249 4642 3093813 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.95385764708583 0.0306584264834814 no 3229 0.025359027264058 4667 688761 SGTC_2543 pimpinellin 60.67 µM -1.95694193559453 0.0304502215623411 no 3230 0.0251771477068437 4562 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1980 st071811 45.7 µM -1.95862304941448 0.0303372320807811 no 3231 0.025078474100555 4708 4974850 SGTC_91 0417-1751 58.384 µM -1.96284954066903 0.0300546990077214 no 3232 0.0248318297033699 4715 6795624 SGTC_2785 7756463 72.73 µM -1.96388681493599 0.0299856935781544 no 3233 0.024771609617536 4650 2201551 SGTC_1944 st076371 56.9 µM -1.96489020290634 0.029919067529092 no 3234 0.0247134734483884 4658 24208455 SGTC_913 3487-1245 167 µM -1.97121020174276 0.0295022294755232 no 3235 0.0243499187538065 4613 4016153 SGTC_3011 9081274 71.4286 µM -1.98682420472259 0.0284930337889983 no 3236 0.0234709406694576 4685 6625322 SGTC_821 1114-0266 29.2 µM -1.98910476307325 0.0283480642941906 no 3237 0.0233448203592242 4688 3123235 SGTC_1487 3970-0795 2.82 µM -1.99398221054464 0.0280400764908011 no 3238 0.0230769993235925 4710 3765103 SGTC_2583 asiatic acid 100 µM -1.99456595847869 0.0280034029694506 no 3239 0.0230451197264594 4654 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1288 0973-0013 65.5 µM -1.99487052847869 0.0279842844536065 no 3240 0.0230285013019737 4706 4315430 SGTC_3176 9106582 49.47 µM -2.00293944114102 0.0274817269184768 no 3241 0.0225918944935958 4713 17018027 SGTC_2021 4019055 173 µM -2.00545406785557 0.0273266544399901 no 3242 0.0224572632389517 4471 44827708 YER133W GLC7 SGTC_1119 parthenolide 318.541 nM -2.00760877952952 0.0271943585174975 no 3243 0.0223424404384662 4699 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2194 5927483 104.545 µM -2.01344697094169 0.0268385856627947 no 3244 0.0220338142011077 4713 760979 SGTC_95 0471-0001 561.058 µM -2.01654270206839 0.0266515173486337 no 3245 0.0218716288248738 4672 4015405 SGTC_2839 9003951 25.97 µM -2.01773938805714 0.0265794966806883 no 3246 0.0218092051885218 4720 2990634 SGTC_1037 k284-1091 78.7 µM -2.0368313893453 0.0254522924572232 no 3247 0.0208334707874735 4672 3334711 SGTC_26 0302-0163 425.158 µM -2.04232532173573 0.0251354444795501 no 3248 0.0205596359704335 4731 3100915 SGTC_1080 nisoldipine 24.4 µM -2.04448249733988 0.0250119421974006 no 3249 0.0204529523785864 4726 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1399 3562-5772 25 µM -2.04744701722566 0.0248430482730547 no 3250 0.0203071069853022 4690 23847490 SGTC_2013 4024628 200 µM -2.0565242253422 0.0243318411021516 no 3251 0.0198660068373425 4688 5230760 SGTC_1169 aniline yellow 25.8 µM -2.05963465152825 0.0241587135623151 no 3252 0.0197167404839424 4667 6051 A DNA damaging agent. SGTC_1183 1254-0324 198 µM -2.0601615205074 0.0241294905528329 no 3253 0.0196915510821276 4719 5799357 SGTC_150 3970-0969 77.2 µM -2.07535115745797 0.0232996727329701 no 3254 0.0189770006972844 4690 6615640 SGTC_2829 7992743 58.44 µM -2.07834540918155 0.0231389616074789 no 3255 0.018838778440499 4658 16462845 SGTC_1754 st042065 16.137 µM -2.09910446256107 0.0220502298684918 no 3256 0.0179038465756723 4504 1126236 YIL048W NEO1 SGTC_464 bw-b 70c 158 µM -2.09931608949214 0.0220393574490573 no 3257 0.0178945230155136 4692 5353454 SGTC_2736 butenafine 14.65 µM -2.10097832232697 0.0219541168309684 no 3258 0.0178214346076548 4665 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.10490529358117 0.0217538436596505 no 3259 0.0176497764100377 4687 688803 SGTC_1969 st069479 40.1 µM -2.11023700802716 0.0214844013354595 no 3260 0.0174189731658531 4708 3895485 SGTC_2641 levomentholum 100 µM -2.11222033328154 0.0213848948903806 no 3261 0.0173337776399153 4716 16666 SGTC_766 1391-0721 126 µM -2.12181052911862 0.0209092206515038 no 3262 0.0169268260519016 4716 1020919 YIL115C NUP159 SGTC_2946 9065502 71.43 µM -2.13190494542082 0.0204182425041877 no 3263 0.0165073307956045 4646 16489101 SGTC_2859 9028643 45.46 µM -2.13221084789632 0.020403517675551 no 3264 0.0164947585407931 4590 17151580 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.14755046086143 0.0196765888612921 no 3265 0.0158747422251191 4646 88881 An O-methylated flavonoid and antioxidant. SGTC_798 1287-0182 476 µM -2.14884608462272 0.0196162103512683 no 3266 0.0158233014402772 4737 1649755 SGTC_2776 terbinafine 19.92 µM -2.15518526802879 0.0193230556264702 no 3267 0.0155736696358381 4707 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1284 0929-0043 16 µM -2.15598119684761 0.0192865124094168 no 3268 0.0155425667133541 4727 1239883 SGTC_3162 9099653 49.47 µM -2.15947372514992 0.0191268546329024 no 3269 0.015406716810378 4716 25237511 SGTC_3014 9081533 49.47 µM -2.16097189197975 0.0190587124660047 no 3270 0.0153487553655806 4716 21367265 SGTC_2541 muurolladie-3-one 83.07 µM -2.16247595743902 0.0189905097714417 no 3271 0.0152907541669318 4673 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1177 0983-0204 23.6 µM -2.16292834095631 0.0189700368358857 no 3272 0.0152733457901478 4736 766818 SGTC_3205 9113483 49.47 µM -2.17380878155476 0.0184832604322493 no 3273 0.014859749384186 4673 17018033 SGTC_208 k072-0098 12.366 µM -2.17658884063926 0.0183606042276893 no 3274 0.0147556292681653 4731 5948901 SGTC_228 caffeine 993.056 µM -2.17863504722149 0.0182707691824718 no 3275 0.0146793952236994 4719 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2840 9008771 71.43 µM -2.18636366250361 0.0179348291939289 no 3276 0.0143945049487702 4692 2992978 SGTC_2843 9000894 45.46 µM -2.19069807732085 0.0177487409081212 no 3277 0.0142368241641436 4744 2242070 SGTC_717 1532-0246 73.2 µM -2.19411550574682 0.0176031851499691 no 3278 0.0141135534118467 4711 9561992 SGTC_1363 1636-0063 10.4 µM -2.20137212641858 0.0172974855824182 no 3279 0.0138548452968594 4727 6072185 SGTC_925 2064-1272 59.6 µM -2.21687450880856 0.0166595805853451 no 3280 0.0133158340709141 4708 6815817 SGTC_721 1187-1332 279 µM -2.22107389061194 0.0164902856467036 no 3281 0.0131729785602877 4735 25730 SGTC_344 k064-0035 6.43 µM -2.22161707551945 0.016468495490774 no 3282 0.0131545974517177 4684 5088750 SGTC_3308 9128332 17.569 µM -2.25328198239328 0.0152401370745681 no 3283 0.0121206875333918 4707 17332805 YDL196W YDL196W SGTC_712 r015-0009 80.6 µM -2.2620092115492 0.0149157466062783 no 3284 0.0118484170890932 4741 6813872 YLR060W FRS1 SGTC_1157 4092-0394 27.6 µM -2.26628388202325 0.0147590352401451 no 3285 0.0117170038162268 4749 3659885 SGTC_2800 7887935 81.82 µM -2.27299624306577 0.0145158151947172 no 3286 0.0115132031702211 4713 2961002 SGTC_3322 9139058 2.11 µM -2.27542639059839 0.0144286142537211 no 3287 0.0114401818698787 4749 4908926 YPR165W RHO1 SGTC_85 0868-0259 160.055 µM -2.27646929706416 0.0143913301867739 no 3288 0.0114089681063833 4719 83173 SGTC_2309 7664088 163.95 µM -2.30626696779612 0.0133605527551716 no 3289 0.0105478598351487 4711 704922 SGTC_1783 st039459 87.517 µM -2.31069042023721 0.0132131032831205 no 3290 0.0104249803817281 4759 729761 SGTC_1082 camptothecin 424.86 nM -2.35095950280123 0.0119342232245278 no 3291 0.00936253584542858 4654 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1327 1436-0082 2.18 µM -2.35347604520882 0.0118579937220268 no 3292 0.0092994030979352 4756 15992205 SGTC_2774 tamoxifen 10.92 µM -2.36529881795159 0.0115054936360823 no 3293 0.00900776420141048 4736 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2115 tiliquinol 12.7705 µM -2.37701263372156 0.0111652537654397 no 3294 0.00872674516430123 4729 71208 A bioactive hydroxyquinoline. SGTC_2608 thymoquinone 42.66 µM -2.38424373077161 0.0109596150026305 no 3295 0.00855713164992582 4708 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2584 androsterone 48.74 µM -2.38642080645253 0.0108983520099819 no 3296 0.00850663559557253 4669 2754130 A steroid. SGTC_225 nsc-122657 1.016 µM -2.39659451685809 0.0106159975754733 no 3297 0.00827411248220726 4771 275685 SGTC_843 0310-0051 143 µM -2.39952039120735 0.0105359837432697 no 3298 0.00820828272174453 4762 2065037 SGTC_1549 4'-methoxyflavonol 74.6 µM -2.40881773798345 0.010285206862879 no 3299 0.00800214415787285 4777 97141 SGTC_1846 st056244 14.8 µM -2.42480722400927 0.00986608378343273 no 3300 0.00765825877500108 4746 5393182 SGTC_2382 9035899 200 µM -2.43191207054428 0.00968468595373181 no 3301 0.00750967648906176 4747 6462679 SGTC_77 0828-0286 12.516 µM -2.44220164390523 0.00942714543539169 no 3302 0.00729899519019938 4686 745345 SGTC_2114 5491910 81.25 µM -2.47327124033788 0.00868549718864076 no 3303 0.00669412432597207 4759 2849228 SGTC_369 0957-0393 4.5 µM -2.49316482151656 0.00823795197783098 no 3304 0.0063305029442894 4745 6997992 SGTC_783 0848-0141 92.7 µM -2.51796629088644 0.00770845342145503 no 3305 0.00590173084979176 4745 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_718 1130-0073 349 µM -2.54968489927828 0.00707507423221655 no 3306 0.00539101601071816 4772 6740020 SGTC_1303 1160-0052 261 µM -2.56580413404687 0.00677114988604105 no 3307 0.00514684679240396 4742 3562476 SGTC_1634 st006576 41 µM -2.57005718518954 0.00669290799613601 no 3308 0.0050840864322109 4749 3915356 SGTC_2241 6772625 37.8075 µM -2.57799313573543 0.00654904723717721 no 3309 0.00496879860081817 4636 2285411 SGTC_790 1575-0012 79.1 µM -2.58763255533835 0.00637798951881048 no 3310 0.00483190027496769 4768 378741 YLR208W SEC13 SGTC_2576 guaiol 23.12 µM -2.59175772644459 0.0063060020584525 no 3311 0.0047743494868368 4722 227829 SGTC_751 0833-0568 350 µM -2.62410274842188 0.00576604527809327 no 3312 0.00434387860895955 4769 6954252 SGTC_1818 st052136 56.3 µM -2.63708510930759 0.00556113010673244 no 3313 0.00418109240776861 4584 674169 SGTC_1068 loratadine 26.9 µM -2.65079480726186 0.00535178157115385 no 3314 0.00401513056990357 4781 3957 A H1 histamine antagonist. SGTC_596 1155-0152 116 µM -2.65428977330965 0.00529954674438548 no 3315 0.00397377723048479 4781 280313 SGTC_202 3594-0513 34.79 µM -2.66196995451031 0.00518635085832968 no 3316 0.00388424061910311 4798 708429 SGTC_574 1315-0397 40 µM -2.68163386809496 0.00490627720247514 no 3317 0.0036631797537272 4772 6794277 SGTC_476 mead acid 10 µM -2.68789612138878 0.00481995729773695 no 3318 0.00359518806844494 4800 5312531 An omega 9 fatty acid. SGTC_3040 9091894 49.47 µM -2.69722016378585 0.00469394119321781 no 3319 0.00349605124234212 4751 25236966 SGTC_61 0978-8327 98.565 µM -2.70597388296818 0.00457831670516788 no 3320 0.00340522009337442 4744 6150059 YHR072W ERG7 SGTC_2531 methyl deoxycholate 70.07 µM -2.80540093723589 0.00343266184935803 no 3321 0.00251270130797303 4737 16667744 Haematoxylin. SGTC_1401 3807-4679 7.6 µM -2.81481053436555 0.0033388677584571 no 3322 0.00244029993917807 4740 3291456 SGTC_371 0195-0006 7.36 µM -2.84021739048213 0.00309701596524848 no 3323 0.00225413997507876 4687 3928593 SGTC_1137 ixabepilone 100 µM -2.84981705096676 0.0030098215462667 no 3324 0.00218721914878326 4757 154225 A novel microtubule stabilizer. SGTC_1712 st032288 53.4 µM -2.89191711727895 0.0026529679203976 no 3325 0.00191449472088407 4687 2883011 SGTC_2692 st077426 47.7 µM -2.89989931290933 0.00258978560356969 no 3326 0.00186641273106487 4783 25238571 SGTC_1463 k081-0032 34.1 µM -2.92247118159191 0.00241841129703926 no 3327 0.00173632877842432 4441 977755 SGTC_1136 pergolide 1.05886 µM -2.92350963422601 0.00241077971671374 no 3328 0.00173054757205248 4765 47811 A dopamine receptor agonist. SGTC_2802 7925815 54.55 µM -2.94468258873564 0.00225985670944285 no 3329 0.00161643065561991 4770 1262923 SGTC_1041 0206-0046 107 µM -2.96133627948659 0.0021472192572357 no 3330 0.0015315364825317 4783 50494 SGTC_264 promethazine 12.5 mM -3.00474979796973 0.00187712256433063 no 3331 0.00132899699312913 4747 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1668 st014914 51.6 µM -3.0150282938793 0.00181787440586094 no 3332 0.0012847764204774 4798 2839556 SGTC_15 0266-0086 27.098 µM -3.02575859749509 0.00175784085548359 no 3333 0.00124005112289845 4799 1712902 YIL048W NEO1 SGTC_1903 st060211 78.3 µM -3.06924012820866 0.00153259548915144 no 3334 0.00107302010654739 4791 688960 SGTC_637 1181-0519 7.26 µM -3.0736563181761 0.00151125749272274 no 3335 0.00105726438091632 4800 6252091 YGR060W ERG25 SGTC_968 1309-0633 340 µM -3.21342748381401 0.000961027640996795 yes 3336 0.00065580456966986 4802 3761976 SGTC_1913 st060213 96.1 µM -3.23989759196163 0.000880345364648049 yes 3337 0.000597863177786632 4783 688959 SGTC_598 3937-0236 20.2 µM -3.25340123880215 0.000841629229855129 yes 3338 0.000570161781892447 4804 1379313 SGTC_1550 gossypolone 36.6 µM -3.2785103534863 0.000773774039386467 yes 3339 0.000521782679997724 4802 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2239 6685329 187.64 µM -3.36813289717289 0.000570580147670492 yes 3340 0.000378395534149929 4779 805680 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -3.42042872006563 0.000476078248888375 yes 3341 0.000312612590475383 4804 66535 A nucleotide analog. SGTC_3003 9075612 71.4286 µM -3.47076105133958 0.000399013627466512 yes 3342 0.000259492801658041 4799 6501993 SGTC_1900 st060200 72.8 µM -3.52632641048373 0.000327474397751934 yes 3343 0.000210683646290428 4801 688945 SGTC_1000 4048-0884 8.67 µM -3.580229812303 0.000269638849831058 yes 3344 0.000171646075284858 4802 13040088 SGTC_599 1935-0052 86.5 µM -3.74889130568583 0.00014433599485442 yes 3345 8.88090197230386e-05 4806 9557311 SGTC_2693 st077581 40.7 µM -3.79589358943679 0.000120712699529139 yes 3346 7.35562969735276e-05 4794 25238761 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -3.83824479308543 0.000102581565539826 yes 3347 6.19584574931381e-05 4809 16486 A toxic proline analog. SGTC_43 0570-0105 72.5 µM -3.96203549182438 6.31567986658457e-05 yes 3348 3.71567449666421e-05 4802 1114046 YDL195W SEC31 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -4.24420309295364 1.98461530072596e-05 yes 3349 1.09685803835604e-05 4807 551469 SGTC_1462 k081-0014 26.5 µM -4.48869207044135 6.86387611821335e-06 yes 3350 3.58308976105787e-06 4567 3270634 SGTC_577 r071-0003 38.6 µM -4.52544334466293 5.82375896563868e-06 yes 3351 3.01345130485546e-06 4809 4568517 YMR134W ERG29