SGTCid condition conc unit RPS21B|YJL136C.score RPS21B|YJL136C.strain.pval RPS21B|YJL136C.strain.significant RPS21B|YJL136C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1781 st038725 66.3 µM 22.7809749166728 7.99367465577868e-114 yes 1 3.53988642001672e-115 3 4270275 YIL048W NEO1 SGTC_33 0986-0033 35.816 µM 7.38002273255371 1.25390540503023e-13 yes 2 7.91312539744245e-14 4 2848082 SGTC_2915 7971052 15.16 µM 6.90721276820214 3.74463986039919e-12 yes 3 2.47134175447779e-12 1 5741558 SGTC_625 k213-0058 121 µM 6.71394340721606 1.41005014111864e-11 yes 4 9.47169021902349e-12 25 3655420 SGTC_800 3448-7362 155 µM 6.25100501381774 2.91424032593308e-10 yes 5 2.03909891623924e-10 41 15991913 SGTC_2688 kanamycin b 96.69 µM 5.3348400613283 6.34304983561523e-08 yes 6 4.78144051683908e-08 217 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1935 st074532 41.6 µM 5.1218662391492 1.97457051111954e-07 yes 7 1.51263234536941e-07 8 2829742 SGTC_1078 idebenone 36.1 µM 5.05011710987495 2.86658362261333e-07 yes 8 2.20769645054712e-07 18 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2902 5787006 60.46 µM 5.01892212465632 3.36576458737792e-07 yes 9 2.59811037046065e-07 12 591003 SGTC_1155 4088-0394 48.2 µM 4.85830441625988 7.57971966040634e-07 yes 10 5.91976409040799e-07 9 2326248 SGTC_2999 9069765 71.4286 µM 4.77798383624084 1.12705766574811e-06 yes 11 8.85308051834715e-07 10 2097066 SGTC_968 1309-0633 340 µM 4.65035948869797 2.09029665517556e-06 yes 12 1.65678468983758e-06 7 3761976 SGTC_2859 9028643 45.46 µM 4.48144016901082 4.62279430742759e-06 yes 13 3.70705095486968e-06 7 17151580 SGTC_2325 6158266 200 µM 4.40969355179042 6.42308572788678e-06 yes 14 5.17585008593247e-06 16 3623240 SGTC_3235 9132602 49.47 µM 4.28780690498089 1.11055266765377e-05 yes 15 9.02229233824043e-06 16 4912240 SGTC_1948 st076329 66.6 µM 4.14298749921584 2.08989914790635e-05 yes 16 1.71405319095121e-05 22 24208413 SGTC_940 3232-1287 54.8 µM 4.10913527153348 2.41584071208945e-05 yes 17 1.98571703802154e-05 30 1585493 YIL048W NEO1 SGTC_582 0987-0078 156 µM 4.03583304663735 3.29420630139017e-05 yes 18 2.72044487739783e-05 65 1625765 SGTC_791 1348-1292 225 µM 4.01573319110725 3.58341034757697e-05 yes 19 2.96306347829352e-05 35 5437054 SGTC_2084 5306078 60.6385 µM 3.96592777897749 4.40696953270318e-05 yes 20 3.65554996383482e-05 19 679340 SGTC_2421 5690543 90.72 µM 3.95858139802976 4.54261733565106e-05 yes 21 3.76981230904422e-05 20 3397993 SGTC_620 0109-0052 432 µM 3.89530545372165 5.88565016723024e-05 yes 22 4.90375275268827e-05 20 493037 SGTC_3244 9134489 49.47 µM 3.87161577350795 6.47869269143611e-05 yes 23 5.40581420068202e-05 19 16584271 SGTC_84 0443-0269 128.823 µM 3.86890001731289 6.5501667415448e-05 yes 24 5.4663729270834e-05 24 6150058 SGTC_176 1486-1328 72.834 µM 3.86045762781419 6.77713049158892e-05 yes 25 5.65874329252914e-05 57 22310231 SGTC_309 k408-0051 1.48 µM 3.81539759576287 8.11917109738597e-05 yes 26 6.79819167005444e-05 55 3640463 SGTC_2906 7926292 26.41 µM 3.7971564588275 8.73052700501457e-05 yes 27 7.31827072449935e-05 29 2966319 SGTC_3346 9158254 43.5805 µM 3.73608510700194 0.000111073669014559 yes 28 9.34537158797337e-05 22 17639500 SGTC_2697 mebhydrolin 72.4 µM 3.68118459628367 0.000137505036077414 yes 29 0.000116076422591653 78 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_830 4076-0286 57.8 µM 3.66780553076368 0.000144785537854719 yes 30 0.000122320567506705 76 6866659 SGTC_2576 guaiol 23.12 µM 3.63425005773164 0.000164665233451425 yes 31 0.000139395186913154 33 227829 SGTC_1445 4239-0156 97.7 µM 3.6106631787704 0.000180137842389906 yes 32 0.000152707538971764 40 4008346 SGTC_2204 7233102 200 µM 3.55198221496797 0.000224728918481528 yes 33 0.000191170351220815 7 2172480 SGTC_1991 st073000 8.92 µM 3.51582005493455 0.000257132215436573 yes 34 0.00021919900276113 96 4301969 YIL048W NEO1 SGTC_2751 anetholtrithion 17.25 µM 3.46785360991692 0.000306853792186757 yes 35 0.000262316499772476 41 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1949 st076024 69.1 µM 3.45215644216099 0.000324978052731455 yes 36 0.000278062593113416 42 2921930 SGTC_3076 9116187 49.47 µM 3.44039871201706 0.000339200572750922 yes 37 0.000290428901841217 25 27241210 SGTC_2994 9053520 71.4286 µM 3.42892163350528 0.000353639813624519 yes 38 0.000302992236516074 37 4647384 SGTC_1178 0988-0033 191 µM 3.41713435922533 0.000369062231623931 yes 39 0.000316420194557474 48 5392207 SGTC_2946 9065502 71.43 µM 3.4102733373805 0.00037832446056564 yes 40 0.000324489012909922 15 16489101 SGTC_232 clozapine 119 µM 3.37480630365553 0.000429742433140628 yes 41 0.000369338309024283 88 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1790 st045711 43.5 µM 3.35360324289685 0.00046350188003797 yes 42 0.000398833247671069 29 585119 SGTC_1190 1486-1332 13 µM 3.31038528013326 0.000540049897933371 yes 43 0.000465838169625471 35 4150046 SGTC_840 0245-0196 390 µM 3.27214898068728 0.000617357574453391 yes 44 0.000533666587056752 31 3827528 SGTC_2176 5809774 33.9695 µM 3.26672081621618 0.000629125878404948 yes 45 0.000544004597176265 33 2870539 SGTC_301 4119-0100 24.5 µM 3.23407439427858 0.0007043832604355 yes 46 0.000610188310878722 118 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_832 4083-0019 164 µM 3.2199976465504 0.000739325663125637 yes 47 0.000640958245615421 162 1990758 SGTC_2008 4012253 172 µM 3.17224610245248 0.000870101878239005 yes 48 0.000756323808772967 64 603940 SGTC_1346 1488-2224 62.4 µM 3.16993127480284 0.000876951926815375 yes 49 0.000762374982558978 40 3722427 SGTC_1315 1237-0019 3.69 µM 3.06044585820986 0.00126357764707976 no 50 0.00110503857511053 38 825140 SGTC_3207 9114163 49.47 µM 3.05675656113022 0.00127897929428797 no 51 0.00111872954866129 76 849233 SGTC_956 1185-0240 191 µM 3.03940654550695 0.00135373815764646 no 52 0.00118522367110218 62 1416193 SGTC_3240 9133527 49.47 µM 3.03108115573512 0.00139101041031572 no 53 0.0012183987083091 44 17617455 SGTC_118 0083-0097 135.343 µM 3.00184855288483 0.00152942742951406 no 54 0.00134172820459657 267 5207356 SGTC_1275 0867-0008 21.1 µM 3.00096643608875 0.00153379305856624 no 55 0.00134562113706501 47 3422836 SGTC_1729 st035615 45.989 µM 2.99569558016971 0.0015601163894233 no 56 0.00136909821036049 77 17385451 SGTC_2137 5261020 140 µM 2.96562394461373 0.00171833649723792 no 57 0.001510347998139 85 763655 SGTC_65 0798-0905 34.986 µM 2.95626492688127 0.00177047934088968 no 58 0.00155694748171306 167 3602145 SGTC_271 rotenone 740 µM 2.92750045513153 0.00193987573927409 no 59 0.00170849280372988 81 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2948 9070189 9.45 µM 2.8954827787204 0.00214564388982851 no 60 0.0018928790072866 81 6473636 YDL196W YDL196W SGTC_2094 5332512 191.667 µM 2.8823914063978 0.00223533423400488 no 61 0.00197334574088285 78 755774 SGTC_1263 0774-1208 64.8 µM 2.87649210002693 0.00227685041082433 no 62 0.00201061130525962 127 906585 SGTC_2658 polymyxin b sulfate 77.05 µM 2.86044191519869 0.00239336173634936 no 63 0.00211525521032788 96 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1380 2291-0730 164 µM 2.85870585378634 0.00240628217010264 no 64 0.0021268650761441 73 2999191 SGTC_478 N-arachidonylglycine 10 µM 2.8388895797289 0.00255829878256093 no 65 0.00226354098200226 18 5283389 SGTC_334 1502-1024 68.5 µM 2.81638463868864 0.00274142726868383 no 66 0.00242837408094842 66 3296216 SGTC_2664 lyso-paf C-16 73.48 µM 2.80392566041398 0.00284782161841626 no 67 0.00252422718756831 55 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1867 st057372 64 µM 2.77897627609489 0.0030721449603267 no 68 0.00272652537605928 54 688837 SGTC_358 0075-0058 9.45 µM 2.76380918825267 0.00321617158568083 no 69 0.0028565468663585 160 1069125 SGTC_1634 st006576 41 µM 2.76160678033867 0.00323758330625107 no 70 0.00287588524498399 81 3915356 SGTC_341 1486-1430 230 µM 2.75489891252545 0.00330358923150262 no 71 0.00293551358054094 80 2054753 YPL210C SRP72 SGTC_1631 benzylvanillin 81.9 µM 2.7485484649266 0.00336719056395998 no 72 0.00299298923502012 95 75506 SGTC_1372 2752-0194 270 µM 2.7428785046583 0.00342490435368057 no 73 0.00304516073377219 64 823334 SGTC_1771 st048882 4.1505 µM 2.72722824774157 0.00358884662235102 no 74 0.00319344212022552 85 4580403 SGTC_2010 4012422 159 µM 2.70145323884458 0.00387424863545214 no 75 0.00345185937307186 102 952393 SGTC_2707 st078556 66.6 µM 2.69214082761069 0.00398226178926214 no 76 0.0035497479971868 58 17250899 SGTC_3056 9094900 49.47 µM 2.67592798156306 0.00417676156983683 no 77 0.00372613284517334 94 25236784 SGTC_1136 pergolide 1.05886 µM 2.66034892570681 0.00437161944374576 no 78 0.00390298686737793 148 47811 A dopamine receptor agonist. SGTC_1242 0402-0103 60.1 µM 2.62660155838932 0.0048218211304577 no 79 0.00431211262852014 98 432868 SGTC_1081 sertraline 6 µM 2.61628028844922 0.00496753342490994 no 80 0.00444467766422126 112 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1343 1487-0095 224 µM 2.61386682791824 0.00500216663190326 no 81 0.00447619617219459 67 4560101 YGL055W OLE1 SGTC_1234 0326-0494 15.5 µM 2.61300352269023 0.00501460720424647 no 82 0.0044875188573722 81 1547813 SGTC_39 0986-0283 58.349 µM 2.61069814577121 0.0050479637541684 no 83 0.00451788049314529 124 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1054 3429-0080 167 µM 2.58946032845755 0.00536467007856555 no 84 0.00480632491083789 107 1162877 SGTC_784 4579-0127 173 µM 2.5763798434858 0.00556841074940497 no 85 0.00499204497621877 103 1948547 SGTC_1354 1498-1681 81 µM 2.56514139368144 0.00574891903221402 no 86 0.00515668840545604 111 5754243 SGTC_1219 1469-0211 33.1 µM 2.5643058353479 0.00576254462780682 no 87 0.00516912021139804 78 6822282 SGTC_450 aminopyrene 156 nM 2.56316007276647 0.00578127537032708 no 88 0.00518621073519602 127 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2013 4024628 200 µM 2.54943442920461 0.00600989611649024 no 89 0.00539488995695676 141 5230760 SGTC_2358 9037157 4 µM 2.54314268093139 0.00611734738913939 no 90 0.00549301788981002 119 2388925 SGTC_1465 k213-0056 144 µM 2.54189221916394 0.00613890457615048 no 91 0.00551270831540028 112 24048857 YMR208W ERG12 SGTC_2914 7968218 45.32 µM 2.53035613970972 0.00634097548930249 no 92 0.00569734008499737 64 2977111 SGTC_432 NS 1619 61.3 µM 2.53009674030524 0.00634558614084899 no 93 0.00570155406487062 128 4552 A K+/calcium channel activator. SGTC_2856 9022925 19.48 µM 2.52957111754256 0.00635493783452227 no 94 0.0057101013649185 127 4944862 SGTC_879 0831-1030 162 µM 2.49494986134865 0.00699840866724261 no 95 0.00629874645290289 176 1549252 SGTC_1066 ketoconazole 628 nM 2.49438708758689 0.0070093270101737 no 96 0.00630874314092388 124 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1291 0993-0025 5.79 µM 2.48034302411362 0.00728670824533678 no 97 0.00656280218316212 93 4353356 SGTC_1203 3992-3522 103 µM 2.47705179109556 0.00735309580188637 no 98 0.00662363387620499 134 5322312 SGTC_2595 hexamethylquercetagetin 100 µM 2.47168074410095 0.00746258061697186 no 99 0.00672397760204207 118 386331 SGTC_2614 arthonioic acid 13.39 µM 2.47123856097497 0.00747165785655632 no 100 0.00673229815912597 107 6710684 SGTC_2651 TUB2.036 5 µM 2.47019876965039 0.0074930412788706 no 101 0.00675189976818544 324 15992207 YFL037W TUB2 SGTC_959 1222-0044 107 µM 2.46707938440264 0.00755751558638872 no 102 0.00681100771098294 110 6083612 SGTC_1296 1068-0102 11.9 µM 2.46550325290891 0.00759027793385415 no 103 0.00684104664259315 95 767053 SGTC_1927 st060202 13.8 µM 2.46340346685184 0.00763411952263566 no 104 0.00688124748530113 108 688887 SGTC_1690 st023502 41.2 µM 2.46261040621943 0.00765073580850576 no 105 0.0068964849883227 89 24207482 SGTC_1232 0279-0259 161 µM 2.45994999291535 0.00770670984701644 no 106 0.00694781879913287 127 1560000 SGTC_348 k064-0012 10.7 µM 2.45910121768324 0.0077246434254353 no 107 0.0069642671122155 109 5066323 SGTC_1184 1269-1718 139 µM 2.43559541442531 0.00823610330843334 no 108 0.00743365151501468 112 5403821 SGTC_475 α-linolenic acid 10 µM 2.42564808676037 0.00846135312858644 no 109 0.00764053998834348 127 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1796 st049173 110.4 µM 2.40344876405578 0.00898362885609912 no 110 0.00812062137751766 74 94134 SGTC_861 0443-0273 110 µM 2.37339663603582 0.00973553310660732 no 111 0.0088126627514912 119 6149169 SGTC_1252 0493-0875 34.8 µM 2.35842218734995 0.0101303093592639 no 112 0.00917640348944738 155 3960963 SGTC_1488 4013-0813 75.9 µM 2.35683694917309 0.0101729080213387 no 113 0.00921566887271618 87 2910057 SGTC_2129 girgensonine 121.053 µM 2.33782019849983 0.0106962360684768 no 114 0.00969828867686918 172 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_630 4356-0227 183 µM 2.33557823868129 0.0107594520528038 no 115 0.00975661692246746 103 779312 SGTC_1324 1418-0026 34.4 µM 2.33247729606835 0.0108474245367855 no 116 0.0098377979730165 140 1372513 SGTC_2834 9001755 58.44 µM 2.3023518756781 0.0117351684322587 no 117 0.0106576682760583 156 2989575 SGTC_2345 9052315 157.45 µM 2.29878265303154 0.0118444143231189 no 118 0.0107586421673568 157 6469265 SGTC_2555 cholic acid 100 µM 2.29459540177612 0.0119737004818724 no 119 0.0108781610195765 124 6708657 Influences liver metabolism. SGTC_2989 9073649 71.4286 µM 2.26714013416435 0.0128521181541724 no 120 0.011690833263956 215 21367202 SGTC_2269 7935389 174.42 µM 2.26389406573421 0.0129595708937672 no 121 0.0117903155148524 152 97605 SGTC_1846 st056244 14.8 µM 2.2549888736944 0.0132583517566437 no 122 0.0120670135855762 188 5393182 SGTC_2273 7815444 169.05 µM 2.25176829630893 0.013367862085097 no 123 0.0121684590786429 146 2824616 SGTC_512 prima-1 270 µM 2.24169329513782 0.0137155042963667 no 124 0.0124906007607255 142 322968 A re-activator of the apoptotic function of mutant p53. SGTC_408 cantharidin 100 µM 2.22701538318236 0.0142359182238927 no 125 0.0129731228508681 178 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2331 7980721 200 µM 2.2221488308277 0.0144121787653389 no 126 0.0131366245885051 174 2981221 SGTC_1642 st009582 77.7 µM 2.22088428279287 0.0144582855288522 no 127 0.0131794000186407 150 6739311 SGTC_127 0180-0333 59.125 µM 2.21675273382517 0.0146098124184152 no 128 0.0133199965261315 235 771601 SGTC_99 0109-0120 622.8 µM 2.21445474779618 0.0146946822704262 no 129 0.0133987561704289 137 759414 SGTC_276 colchicine 750 µM 2.18995548573095 0.0156261746653407 no 130 0.0142637326599391 166 2833 A microtubule depolymerizer. SGTC_1285 0929-0069 65.5 µM 2.17001020659695 0.016421506178834 no 131 0.0150030363739733 179 1206237 SGTC_140 0062-0056 502.533 µM 2.16023589395839 0.0168237554876549 no 132 0.0153772063962923 201 3758964 SGTC_391 gliotoxin 8.33 µM 2.14993174213058 0.0172569049352787 no 133 0.0157803071907615 225 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2729 fluphenazine 10.66 µM 2.14782520728677 0.0173466194103287 no 134 0.0158638218694037 176 3372 An atypical antipsychotic. SGTC_815 1582-0027 36.9 µM 2.14779624831836 0.0173478555042158 no 135 0.0158649725987451 179 3128206 SGTC_2369 9071472 200 µM 2.14251126515614 0.0175747046746443 no 136 0.0160761815747018 188 17296037 SGTC_2801 7907800 81.82 µM 2.12778316837889 0.0182202871027367 no 137 0.016677532764953 205 6620925 SGTC_1839 st053978 48 µM 2.12691080579559 0.0182591515578686 no 138 0.0167137474289965 184 3788398 SGTC_1695 st026914 34.495 µM 2.10930803243603 0.0190585928545194 no 139 0.0174590009577967 195 3289191 SGTC_18 0111-0177 500 nM 2.10890905667605 0.0190770521939095 no 140 0.0174762161580022 290 721752 SGTC_1181 1222-0449 220 µM 2.09905558031037 0.0195377886032697 no 141 0.0179060007496782 190 658318 SGTC_939 1165-0479 45.3 µM 2.08715340239949 0.0201068900323099 no 142 0.0184371350441552 235 1377347 SGTC_2004 4023728 41.89 µM 2.08331340655463 0.0202934730202356 no 143 0.0186113327529949 232 360084 YDR527W RBA50 SGTC_3210 9128157 49.47 µM 2.07947834606317 0.0204812790619942 no 144 0.0187867030285711 246 17590849 SGTC_571 k831-0106 44.2 µM 2.07645473778506 0.0206303839947204 no 145 0.0189259565890224 180 4783639 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.06009343043133 0.0214532591223124 no 146 0.0196948049042291 294 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2760 etidronate 98.04 µM 2.0439805902191 0.0222905853954144 no 147 0.0204777323390837 235 3305 A chelator and antioxidant. SGTC_1254 0550-0035 264 µM 2.04290508589838 0.0223474437895309 no 148 0.0205309173852508 216 15121435 SGTC_818 4072-2707 53.5 µM 2.0346421351775 0.0227883726691501 no 149 0.0209434472333257 178 882871 SGTC_3173 9105693 49.47 µM 2.03341393091167 0.0228545340071429 no 150 0.0210053605370538 231 17096658 SGTC_2177 5811945 192 µM 2.02537388567226 0.0232916469939466 no 151 0.0214144934351538 212 5343475 SGTC_1824 st053723 68.6 µM 2.02434091003718 0.0233483135622759 no 152 0.0214675435349417 216 675225 SGTC_2101 5377231 179.231 µM 2.02382168605132 0.023376840733997 no 153 0.0214942510319571 168 2844213 SGTC_1705 st027868 56.3335 µM 2.0217487806936 0.0234910226287336 no 154 0.021601155800741 183 292948 SGTC_934 2950-0684 338 µM 2.01663533800177 0.0237746942027144 no 155 0.021866791204479 217 1121253 SGTC_3144 9087057 49.47 µM 2.0084963532049 0.0242321472328716 no 156 0.022295286593933 208 17249618 SGTC_2960 9079389 5.97 µM 2.00697175929363 0.0243186541884978 no 157 0.0223763350424679 224 16457355 SGTC_2144 5628481 200 µM 2.00556361513017 0.0243987838858195 no 158 0.0224514135715849 211 2818399 SGTC_2088 5278280 127.392 µM 1.99754097640806 0.0248595480901668 no 159 0.0228832238825687 260 791502 SGTC_2142 5622915 118.518 µM 1.99536024378712 0.0249860481290306 no 160 0.0230018018506999 180 5322196 SGTC_3004 9076122 71.4286 µM 1.98493641928358 0.0255981925237607 no 161 0.0235757729026012 229 44782551 SGTC_3059 1327-0034 3 µM 1.97377672684371 0.0262674181565618 no 162 0.0242035681426644 265 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_470 aa-861 153 µM 1.96966153452414 0.0265178617615965 no 163 0.0244385871016622 281 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2488 5268135 45.7 µM 1.96899364702629 0.0265586958368087 no 164 0.0244769103103401 306 1270356 YLR208W SEC13 SGTC_961 1252-1571 372 µM 1.96498746776964 0.0268047342948986 no 165 0.0247078440253257 244 6813498 SGTC_1871 st057448 67.3 µM 1.95451843079517 0.0274566861782119 no 166 0.0253199686812916 259 691747 SGTC_2605 digitonin 300 nM 1.9408468680308 0.0283279297324781 no 167 0.0261384271169805 283 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2186 6124449 200 µM 1.93892153257593 0.0284524535599336 no 168 0.0262554467860176 226 3834182 YLR033W RSC58 SGTC_1913 st060213 96.1 µM 1.93252527996082 0.0288694143019781 no 169 0.0266473524531373 279 688959 SGTC_1961 st076550 68.7 µM 1.92319160788854 0.0294869639629445 no 170 0.0272279954072961 205 1579337 SGTC_1383 3049-0032 20.7 µM 1.91532617895195 0.0300158474370313 no 171 0.027725459503515 245 712864 SGTC_1104 tacrolimus 29.8 µM 1.89850783416575 0.0311731562994702 no 172 0.0288146083804428 255 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2748 diazoxide 86.69 µM 1.87848523961761 0.0325988368641533 no 173 0.0301574072095258 185 3019 A potassium channel activatior. SGTC_1755 st041960 45.185 µM 1.87151807680551 0.0331073650766164 no 174 0.0306366533407981 245 2257073 SGTC_816 0325-0417 81.3 µM 1.87039213892514 0.0331901567200909 no 175 0.0307146914065273 221 68101 SGTC_1607 st000305 50.6 µM 1.86794280821447 0.0333708482282441 no 176 0.0308850215637527 255 5457690 SGTC_2443 5493264 126.67 µM 1.86767430670453 0.0333907052374416 no 177 0.0309037410234473 247 5340055 SGTC_2775 cyproheptadine 69.59 µM 1.86331865250811 0.0337141886090979 no 178 0.0312087236963616 242 2913 A selective serotonin reuptake inhibitor. SGTC_2678 equilin 100 µM 1.86106224466747 0.0338827776156574 no 179 0.0313676935737053 271 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2517 totarol 10 µM 1.8498767860019 0.0347287756356312 no 180 0.0321656552089693 254 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_542 3381-0244 89.3 µM 1.84701207192772 0.0349482126729058 no 181 0.0323726953545103 302 1112843 SGTC_2102 5377816 72.7585 µM 1.83981999189918 0.0355041444824254 no 182 0.0328973346685615 274 1379702 SGTC_2663 amphotericin b 100 µM 1.83172518377063 0.036138506422138 no 183 0.0334961873361217 259 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1964 st076914 61 µM 1.8306105998583 0.0362265749951991 no 184 0.0335793426496103 228 24208661 SGTC_511 blebbistatin 171 µM 1.82921173513527 0.0363373545136736 no 185 0.0336839475597231 270 3476986 A myosin inhibitor. SGTC_1096 rimcazole 32.2 µM 1.82909760894619 0.0363464046661865 no 186 0.0336924935552942 239 18528119 A dopamine reuptake inhibitor. SGTC_1210 3013-0140 750 nM 1.81291093316557 0.0376488100546226 no 187 0.0349227798401708 257 905973 SGTC_249 wiskostatin 11.211 µM 1.81181391534581 0.0377384390903977 no 188 0.03500747712181 244 2775510 A n-wasp and actin depolymerizer. SGTC_1128 3448-9350 235 µM 1.80972834478907 0.0379093155805909 no 189 0.0351689623354685 283 619386 SGTC_1844 rapamycin 4 nM 1.80812352367851 0.0380412323203076 no 190 0.0352936388830911 460 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1156 4092-0367 4.88 µM 1.80392924452111 0.0383877721967244 no 191 0.0356211998659651 310 1357585 SGTC_2588 indole-3-carbinol 100 µM 1.7951525846425 0.0391212455768688 no 192 0.036314696294388 346 3712 Induces cell cycle arrest. SGTC_3065 9113888 49.47 µM 1.79514731377268 0.0391216894718947 no 193 0.0363151160742661 261 16648368 SGTC_2073 5212005 126 µM 1.78854361488694 0.039681059719879 no 194 0.036844172773463 190 691789 SGTC_3075 9116269 49.47 µM 1.78668544635799 0.0398396241321369 no 195 0.0369941713114618 262 17015205 YNL244C SUI1 SGTC_2391 6285546 200 µM 1.78390428109467 0.0400779132715403 no 196 0.0372196100775599 321 846083 SGTC_945 3381-0768 11.3 µM 1.7803049826087 0.0403880174901204 no 197 0.0375130310730249 318 1126236 YIL048W NEO1 SGTC_565 1418-0001 44.5 µM 1.77937353065315 0.0404685850184335 no 198 0.0375892715310226 338 2862145 SGTC_2428 5615643 7.78 µM 1.774314642795 0.0409084438475651 no 199 0.0380055599188581 296 2253075 SGTC_2024 5144227 134 µM 1.77240313645295 0.041075651253674 no 200 0.0381638307661191 332 3475211 SGTC_2483 5729050 27.16 µM 1.7620064783698 0.0419948193263496 no 201 0.0390341014619951 387 2865180 SGTC_1360 1598-0022 39.8 µM 1.75872117741211 0.0422887106579668 no 202 0.0393124392803433 373 761525 SGTC_2975 9084847 53.72 µM 1.75703137599217 0.0424405210751228 no 203 0.039456230662108 313 27211724 SGTC_465 cgp-37157 41 µM 1.75440975256809 0.0426769177535739 no 204 0.0396801607164382 189 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_764 1951-2361 146 µM 1.74593386436312 0.0434484971640452 no 205 0.0404112222931706 310 5438930 SGTC_2502 avocadyne acetate 18.59 µM 1.72572883939172 0.0453332662474924 no 206 0.0421981035797816 383 3952079 SGTC_1148 3909-7663 27.7 µM 1.72546728517549 0.0453580890567591 no 207 0.042221647290547 309 4084526 SGTC_1039 k821-0043 94 µM 1.72326796198862 0.0455672486045254 no 208 0.042420039308824 313 15992768 SGTC_2329 6138490 200 µM 1.72325703620469 0.0455682895985174 no 209 0.0424210267583861 297 720019 SGTC_60 0986-0278 202 µM 1.72220311784973 0.045668795437075 no 210 0.0425163651293215 230 3110598 SGTC_2625 euphol 100 µM 1.72141090085805 0.0457444616529585 no 211 0.0425881437854263 359 6708538 A triterpene alcohol. SGTC_2950 9072895 21.46 µM 1.71927269835443 0.0459491887014835 no 212 0.0427823643977378 371 17332245 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.70793368716312 0.0470472014461047 no 213 0.0438243238064918 293 279621 SGTC_1268 0828-0275 2.46 µM 1.7063432812555 0.0472028769319871 no 214 0.0439720920784709 308 745337 SGTC_337 1315-0038 354 µM 1.70503136153675 0.0473316035886848 no 215 0.0440942877667762 303 1626437 SGTC_2447 5741742 33.78 µM 1.70396982355692 0.0474359683608279 no 216 0.0441933625034435 350 1776504 SGTC_3238 9133470 49.47 µM 1.70274835596158 0.047556284613375 no 217 0.0443075856375911 268 3534688 SGTC_64 000l-0018 272.079 µM 1.70232087789671 0.0475984494964006 no 218 0.0443476165672641 499 6811119 SGTC_52 0329-0193 875 nM 1.70227721570152 0.0476027578615942 no 219 0.0443517069276239 334 3739292 SGTC_219 mitoxanthrone 164.414 µM 1.69711561661586 0.0481142834564448 no 220 0.0448374021539913 346 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1590 st077108 57.8 µM 1.69648878405132 0.0481767023125776 no 221 0.0448966762337452 278 5489485 SGTC_2140 5586273 200 µM 1.6958859118586 0.0482367963446936 no 222 0.0449537440864066 266 854421 SGTC_1130 3454-2858 15.9 µM 1.69503969924278 0.0483212475888719 no 223 0.0450339450161154 372 715628 YIL048W NEO1 SGTC_2199 6590217 200 µM 1.68051355208794 0.0497894663621865 no 224 0.0464287198989052 252 703109 SGTC_3011 9081274 71.4286 µM 1.67885120378623 0.0499597324013329 no 225 0.0465905232559314 346 6625322 SGTC_290 2043-6722 48.1 µM 1.67750881862886 0.0500975648228212 no 226 0.0467215132326954 318 773758 YLR208W SEC13 SGTC_1089 terbinafine 2.25 µM 1.67567965960193 0.0502858656698806 no 227 0.0469004780419246 316 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2887 9044784 58.44 µM 1.67503807476977 0.0503520464153907 no 228 0.0469633807518893 341 6465546 SGTC_2175 5807670 165.306 µM 1.66726937288456 0.0511589240052043 no 229 0.047730426889228 314 241186 SGTC_375 3970-0961 9.27 µM 1.66555716285782 0.0513381349536021 no 230 0.0479008246243096 354 2898222 SGTC_1847 st056231 15 µM 1.66234881800568 0.0516752852990422 no 231 0.0482214274035384 419 5393180 SGTC_1041 0206-0046 107 µM 1.65436558515473 0.0525218478725841 no 232 0.0490266272779935 336 50494 SGTC_25 0118-0223 35.662 µM 1.65055001980886 0.0529303297826235 no 233 0.0494152458178292 335 5333628 SGTC_1530 rhein 70.4 µM 1.64706797115119 0.0533053017419477 no 234 0.0497720377816429 360 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3090 9117696 49.47 µM 1.64692673182028 0.0533205557251228 no 235 0.0497865532833862 322 7923821 SGTC_1424 4048-1941 275 µM 1.64391542898422 0.0536466032722606 no 236 0.0500968363335678 368 X1424 SGTC_2025 5147754 141 µM 1.63939679718153 0.054138816830217 no 237 0.0505653241240729 313 315777 YLR208W SEC13 SGTC_1206 3978-0017 132 µM 1.63909763087911 0.0541715306841019 no 238 0.0505964641927834 330 3873677 SGTC_2362 9071156 126 µM 1.62171553023124 0.0560992694499972 no 239 0.0524321359801888 357 653133 SGTC_3020 9089140 49.47 µM 1.62129060335571 0.0561470641535506 no 240 0.0524776646611334 372 17217859 SGTC_2398 5228213 48.84 µM 1.61917650622095 0.056385329904149 no 241 0.0527046457028002 447 80771 YMR134W ERG29 SGTC_520 3584-0023 682 µM 1.61440489779683 0.0569260351362285 no 242 0.0532198150281919 365 1340790 SGTC_2608 thymoquinone 42.66 µM 1.60606178002879 0.0578812554526957 no 243 0.054130168215619 313 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2257 7960413 200 µM 1.60534076573963 0.0579643938111004 no 244 0.0542094162149765 418 2974689 YIL048W NEO1 SGTC_3283 9109332 35.8195 µM 1.60184610759685 0.0583686847696281 no 245 0.0545948221471328 287 17027281 SGTC_1876 myriocin 605 nM 1.59453458206966 0.059221704271777 no 246 0.0554081757581998 350 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_594 1487-1584 10.8 µM 1.58959301098827 0.0598037414873652 no 247 0.05596328673638 379 5013332 SGTC_3312 9133330 71.43 µM 1.58840054265196 0.0599448639656179 no 248 0.0560978974282993 371 17617324 SGTC_1334 1486-0610 236 µM 1.58764558023624 0.0600343446196464 no 249 0.0561832525835401 397 3742339 SGTC_380 3970-0968 6 µM 1.58477788903697 0.0603751864024161 no 250 0.0565084039047029 370 2891601 SGTC_2744 captopril 92.04 µM 1.5830472300761 0.0605816168872791 no 251 0.0567053499233431 271 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1663 st014140 55.4 µM 1.58054909698996 0.0608805638046018 no 252 0.0569905862658724 431 4207120 SGTC_994 3910-0338 138 µM 1.5766494320461 0.0613495335128733 no 253 0.0574381059438126 426 3479481 SGTC_1255 0566-0045 221 µM 1.57638134069468 0.061381877296838 no 254 0.0574689729815756 403 2788469 SGTC_1403 3909-7815 62.9 µM 1.56875733217443 0.0623072603274018 no 255 0.0583522469637926 325 6615483 SGTC_1335 1486-0900 202 µM 1.55961188207328 0.0634316249944412 no 256 0.0594258134438041 432 X1335 SGTC_2829 7992743 58.44 µM 1.55839030056084 0.063582997421074 no 257 0.0595703772498292 405 16462845 SGTC_1914 st062367 72.6 µM 1.55493580864821 0.064012582767874 no 258 0.0599806790178291 368 978205 SGTC_2335 9018011 154.17 µM 1.55228533417762 0.0643437114204882 no 259 0.0602969827485912 446 6458208 SGTC_1301 naphtanilide LB 4.81 µM 1.54528885176127 0.065224189713615 no 260 0.0611382054074276 412 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_839 0122-0028 230 µM 1.54015892269615 0.0658756887071882 no 261 0.0617608099751212 466 759448 SGTC_721 1187-1332 279 µM 1.53036368927441 0.0671336750831132 no 262 0.0629633657866463 294 25730 SGTC_1388 3346-4487 254 µM 1.52963643310751 0.0672278112314064 no 263 0.0630533730327921 441 3345614 SGTC_2874 9043904 71.43 µM 1.52927540331464 0.0672745808734357 no 264 0.0630980922916085 316 4463428 SGTC_1801 st050089 28.441 µM 1.52732654704252 0.0675274801546659 no 265 0.063339915688581 532 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2920 7982904 15.77 µM 1.52573795505909 0.0677341716149598 no 266 0.0635375690126996 356 6456808 SGTC_1271 0832-2808 169 µM 1.52460610823338 0.0678817339237152 no 267 0.0636786864752288 421 3663794 SGTC_1015 4130-4525 82 µM 1.52231264138143 0.0681815012214306 no 268 0.0639653810311214 419 1363237 SGTC_2963 9082507 9 µM 1.52008391848861 0.0684737840737838 no 269 0.0642449429051051 393 16459611 SGTC_1051 3253-3903 78 µM 1.51633273391189 0.0689679094678153 no 270 0.0647176192657043 448 5509239 SGTC_1570 verbenone 133 µM 1.5150188087017 0.0691416349303069 no 271 0.0648838205015033 405 29025 A natural terpanoid with antifungal properties. SGTC_1554 st069299 38.7 µM 1.50955575680098 0.0698675700191932 no 272 0.0655784089593638 412 24207999 SGTC_246 cycloheximide 667 µM 1.50383736115577 0.0706337038546468 no 273 0.0663116243452813 354 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2773 thioridazine 9.09 µM 1.50302655911171 0.0707428533705379 no 274 0.0664160976527195 415 5452 An antipsychotic. SGTC_2620 irigenin 100 µM 1.50273185368767 0.0707825584756749 no 275 0.0664541025418094 448 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1377 2944-0135 198 µM 1.49923505418073 0.0712549834914042 no 276 0.0669063320639087 458 1894137 SGTC_150 3970-0969 77.2 µM 1.4988122362686 0.071312270746006 no 277 0.0669611746576563 518 6615640 SGTC_2041 5107442 45.335 µM 1.49576459880811 0.0717262390247824 no 278 0.0673575048215479 429 793005 SGTC_2277 7947813 106.88 µM 1.49014626840587 0.0724942191207001 no 279 0.0680928903844396 426 1246798 SGTC_1995 st072814 61.1 µM 1.48595690764065 0.0730709586099735 no 280 0.0686452597868677 397 5769371 SGTC_1031 k035-0009 16 µM 1.48585513401814 0.0730850131070618 no 281 0.0686587215603571 469 5180959 SGTC_2302 7771753 200 µM 1.48398451243196 0.0733437064508623 no 282 0.0689065146929799 486 2203047 SGTC_507 nimesulide 162 µM 1.47836773521604 0.074124675225357 no 283 0.0696546882734802 438 4495 A COX2 inhibitor. SGTC_3237 9133362 49.47 µM 1.47819206962712 0.0741492021901394 no 284 0.0696781879782493 407 43845137 SGTC_368 fentichlor 4.58 µM 1.47404917392555 0.0747294446207254 no 285 0.0702341758785888 384 7329 A pesticide. SGTC_262 fenpropimorph 62.5 µM 1.47377778857038 0.0747675746734771 no 286 0.0702707152658178 387 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3040 9091894 49.47 µM 1.47185133096765 0.0750386717084525 no 287 0.070530514313922 378 25236966 SGTC_364 0083-0097 67.7 µM 1.47120746496703 0.0751294454609732 no 288 0.0706175094955261 430 5207356 SGTC_516 3992-2719 87.3 µM 1.46778507927936 0.0756133474385583 no 289 0.0710813058395328 397 5350887 YDR037W KRS1 SGTC_581 0958-0271 211 µM 1.46544171379641 0.0759460504997447 no 290 0.0714002218309591 541 4591145 SGTC_259 usnic acid 108.925 µM 1.46173809711242 0.0764741488232323 no 291 0.0719064965865876 454 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2629 bisabolol 100 µM 1.4593110348989 0.0768217356013925 no 292 0.0722397597906203 467 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1950 st077106 7.18 µM 1.45566678120419 0.0773458939267797 no 293 0.0727423785786949 457 13831864 SGTC_797 k781-0471 270 µM 1.45073052168752 0.0780602095544341 no 294 0.0734274564933357 455 23738129 SGTC_1220 1838-0075 193 µM 1.44927017579476 0.0782724895081948 no 295 0.0736310732653545 459 5529645 SGTC_2693 st077581 40.7 µM 1.44590213449468 0.0787637462384575 no 296 0.0741023265854754 558 25238761 SGTC_2496 diffractaic acid 79.83 µM 1.4415512019094 0.0794018197485607 no 297 0.0747145115487283 490 94870 An apoptosis inducer which activates caspases. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.43965718567355 0.0796808004111352 no 298 0.0749822060077646 471 5393153 SGTC_258 haloperidol 50.781 µM 1.43655406217445 0.0801394793106782 no 299 0.0754223722444201 475 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1333 1482-0047 286 µM 1.43517954501457 0.0803432861294884 no 300 0.0756179704538906 494 3811116 SGTC_2467 5474540 200 µM 1.43488605493267 0.0803868541307501 no 301 0.0756597850617275 466 5413519 SGTC_212 3807-4682 38.772 µM 1.42980226692544 0.0811443674792382 no 302 0.0763868891446417 604 3125501 YBL034C STU1 SGTC_2384 9036245 200 µM 1.42803458768674 0.0814090199830839 no 303 0.0766409516871732 472 6462766 SGTC_1504 k297-0033 30 µM 1.42550633940191 0.0817886737428295 no 304 0.077005444462032 376 4388117 SGTC_2093 5331342 194.4 µM 1.42504671522039 0.0818578362190888 no 305 0.0770718489102245 470 33839 SGTC_2691 st077356 60.2 µM 1.42445203416024 0.0819473869313769 no 306 0.0771578303382807 475 2839272 SGTC_1803 st050068 52.4 µM 1.42372677412285 0.0820567009167305 no 307 0.077262790035098 678 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1792 st045773 43.6 µM 1.42244232144518 0.082250568086872 no 308 0.0774489422496814 460 2919270 SGTC_1971 st069429 63.5 µM 1.4207934430927 0.08249994476806 no 309 0.0776884087252304 426 1246522 YGL099W LSG1 SGTC_930 2810-3379 265 µM 1.41549273105949 0.0833054818077911 no 310 0.0784620390781063 534 1015764 SGTC_932 2857-0803 154 µM 1.41519398631789 0.0833510567567223 no 311 0.0785058136264658 501 674898 SGTC_2218 6965428 192.983 µM 1.4151641949667 0.0833556025983111 no 312 0.0785101799163872 468 675684 SGTC_3309 9129340 25.759 µM 1.41172179535913 0.0838821318019744 no 313 0.079015946606749 484 17158987 SGTC_717 1532-0246 73.2 µM 1.40747935632834 0.0845344615456211 no 314 0.0796426472233987 491 9561992 SGTC_2311 7694451 200 µM 1.40662536273003 0.0846662329835285 no 315 0.0797692541249656 475 2163142 SGTC_1739 st037196 92.5 µM 1.40136684160319 0.0854810208137081 no 316 0.0805522012538552 497 612214 SGTC_2903 5923464 63.88 µM 1.39406652154275 0.0866218937565301 no 317 0.081648758849717 450 2876576 SGTC_658 3253-0951 102 µM 1.38876913544368 0.0874568527471443 no 318 0.0824514817417957 605 1184878 SGTC_3336 9143619 71.43 µM 1.38861043610872 0.0874819588368952 no 319 0.0824756210907123 516 45595730 SGTC_850 0388-0143 75.9 µM 1.38774498158514 0.0876189676093044 no 320 0.0826073567916531 456 67273 SGTC_1080 nisoldipine 24.4 µM 1.38725813639442 0.0876961096521977 no 321 0.0826815318072789 524 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1825 st052143 62.6 µM 1.38564173627773 0.0879525963726132 no 322 0.0829281636377187 431 674173 SGTC_3013 9080133 71.4286 µM 1.38354536586007 0.0882860763870397 no 323 0.0832488535784821 534 17050193 SGTC_1365 1672-3266 55.4 µM 1.38153416208639 0.0886068933611951 no 324 0.0835573907215713 513 6415873 SGTC_452 diindolylmethane 8 µM 1.3770555751464 0.0893244132357551 no 325 0.0842475330947089 429 3071 Inhibits expression of several cancer promoting factors. SGTC_1259 0671-0132 43 µM 1.37690017060707 0.0893493881568646 no 326 0.0842715572329427 492 X1259 SGTC_376 3970-0862 59.1 µM 1.37522848928471 0.0896183710907642 no 327 0.084530309273191 508 3135186 SGTC_1754 st042065 16.137 µM 1.37229099184013 0.0900924888204442 no 328 0.0849864343950472 649 1126236 YIL048W NEO1 SGTC_2423 st077119 87.2 µM 1.37168750187372 0.0901901235932688 no 329 0.085080370390242 495 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_519 k048-0011 62.8 µM 1.36820261912779 0.090755458236425 no 330 0.0856243310095845 496 6836379 SGTC_3318 9139014 38.6185 µM 1.36750391198742 0.0908691217112512 no 331 0.0857337059600153 461 16643984 SGTC_2803 7707263 71.43 µM 1.36344081849997 0.0915321865559235 no 332 0.0863718120638884 468 2199229 SGTC_2808 7946468 45.46 µM 1.36044046806025 0.0920241168217141 no 333 0.0868452898529893 565 2970879 SGTC_3031 9088762 49.47 µM 1.35974516988276 0.0921383951305903 no 334 0.0869552893762427 509 205253 SGTC_2851 9015922 71.43 µM 1.35757567102055 0.0924956464695754 no 335 0.0872991835736678 512 2996893 SGTC_168 3970-0862 530.542 µM 1.35377210900577 0.0931244506167658 no 336 0.0879045472545074 699 3135186 SGTC_411 enrofloxacin 100 µM 1.35310089998976 0.093235741933632 no 337 0.0880116990934706 485 71188 A bacterial gyrase inhibitor. SGTC_977 1348-1378 135 µM 1.35302059694089 0.0932490633401993 no 338 0.0880245251960861 529 X977 SGTC_914 3820-6779 408 µM 1.35075866146856 0.0936248718772419 no 339 0.0883863770873299 486 2893481 SGTC_3348 9149464 3.537 µM 1.34733774017543 0.0941953626741936 no 340 0.0889357412382858 511 1951442 SGTC_269 exalamide 29 µM 1.34641614038697 0.0943494910588693 no 341 0.0890841742578648 484 3316 A derivative of salicylamide. SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.3429775625767 0.0949262005286462 no 342 0.0896396196450843 477 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2400 5203494 178.7 µM 1.33958165528872 0.0954982982202426 no 343 0.0901906955745952 482 6777674 SGTC_500 h-89 112 µM 1.3384003112315 0.0956979092469818 no 344 0.090382988754696 556 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1435 4092-0789 56.7 µM 1.33759476107862 0.0958341985128622 no 345 0.0905142865839568 526 2248285 SGTC_61 0978-8327 98.565 µM 1.33701288201285 0.0959327341322554 no 346 0.0906092159744919 536 6150059 YHR072W ERG7 SGTC_133 0724-0033 378.92 µM 1.33595478792802 0.0961121030778622 no 347 0.0907820257659736 488 280309 SGTC_3068 9116768 49.47 µM 1.3352433889441 0.0962328385376096 no 348 0.0908983501208715 484 41904888 SGTC_2223 6903751 107.57 µM 1.33470007379263 0.0963251226171221 no 349 0.090987264711728 459 5598863 SGTC_2938 9059746 27.26 µM 1.33186088097427 0.0968084281219096 no 350 0.091452953876961 483 6471769 SGTC_68 0986-0284 82.829 µM 1.32713671658667 0.0976165480160858 no 351 0.0922317307891418 491 423278 YIL048W NEO1 SGTC_2387 9077560 195.08 µM 1.32704469576657 0.0976323381491312 no 352 0.0922469489795965 525 5303272 SGTC_2250 alverine citrate 130 µM 1.32223385022694 0.098460456232813 no 353 0.0930451462143751 663 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1637 st007924 17.4 µM 1.31319620176649 0.10003004248376 no 354 0.0945584217684233 536 683336 SGTC_1480 1070-0044 41.2 µM 1.30971109974866 0.100640162848182 no 355 0.0951467935844624 533 3124987 SGTC_2053 5265679 138 µM 1.30919091652963 0.100731461185543 no 356 0.0952348441798911 573 764595 SGTC_2028 5153890 36.43 µM 1.30884714417312 0.100791830460624 no 357 0.0952930669049455 533 2830968 YPR165W RHO1 SGTC_3003 9075612 71.4286 µM 1.30723867480836 0.101074641540142 no 358 0.0955658322046972 527 6501993 SGTC_851 0394-0702 453 µM 1.3051632490126 0.101440409836604 no 359 0.0959186327012089 603 762646 SGTC_41 0478-0632 82.643 µM 1.30514404381477 0.101443799012991 no 360 0.0959219018492368 626 3750424 SGTC_2238 6671620 73.2395 µM 1.29833287695546 0.102650985387097 no 361 0.0970864867907308 525 729941 SGTC_442 cape 100 µM 1.2900949910886 0.10412494776087 no 362 0.0985088393936756 499 5281787 SGTC_1583 clindamycin 39.6 µM 1.28266427021096 0.10546759732221 no 363 0.0998048613931651 528 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_91 0417-1751 58.384 µM 1.2804789918061 0.105864825537516 no 364 0.100188364295097 684 6795624 SGTC_2435 5706476 10.6 µM 1.2795044184054 0.106042326504148 no 365 0.10035974234716 609 5725375 SGTC_2567 aureobasidin a 60 nM 1.27496127958833 0.106872615172623 no 366 0.10116147368058 580 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1462 k081-0014 26.5 µM 1.27493526869362 0.106877382301194 no 367 0.101166077242772 409 3270634 SGTC_580 1123-0028 41 µM 1.27473924841696 0.106913312715146 no 368 0.101200774982805 627 1677248 YPR107C YTH1 SGTC_2861 9024595 19.48 µM 1.27445353171567 0.106965700043469 no 369 0.10125136550524 436 16482810 SGTC_103 0844-0104 51.839 µM 1.27355110774507 0.107131284777294 no 370 0.10141127451687 674 5375804 SGTC_1874 staurosporine 7.6 µM 1.27093599188519 0.107612173186148 no 371 0.101875710392977 589 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_595 3909-8003 73.7 µM 1.26768759358656 0.108211678065565 no 372 0.102454768508382 567 699517 SGTC_152 4469-0003 551.229 µM 1.26525563268557 0.108662077112465 no 373 0.102889852722598 549 697280 SGTC_2679 rapamycin 1 nM 1.26412453994116 0.10887201417861 no 374 0.103092664930452 671 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_831 k061-1017 217 µM 1.26265339203975 0.109145503433646 no 375 0.103356885419726 745 1240153 SGTC_2699 st077704 54.6 µM 1.26078883168799 0.109492837734446 no 376 0.103692469332741 557 645852 SGTC_2479 5617353 43.85 µM 1.25892552398643 0.109840730974687 no 377 0.104028616821735 577 2731746 SGTC_175 3793-3120 23.7 µM 1.25812591076622 0.109990267660685 no 378 0.10417311199843 535 5322297 SGTC_3273 9137859 49.47 µM 1.25802746516799 0.110008688191516 no 379 0.104190911795987 538 2377234 SGTC_1003 4049-0218 100 µM 1.25781453454793 0.110048538021946 no 380 0.104229418995808 601 295161 SGTC_562 3772-2733 112 µM 1.25581470240083 0.110423310817171 no 381 0.104591579900199 666 2876874 YIL048W NEO1 SGTC_927 2425-1185 123 µM 1.25486920954238 0.110600816426006 no 382 0.104763121552883 558 730375 SGTC_2513 baicalein 25.65 µM 1.2532589854544 0.110903588389576 no 383 0.105055734805955 581 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_31 0508-1974 57.237 µM 1.25092245603411 0.111343983404865 no 384 0.1054813850404 562 6810525 SGTC_2641 levomentholum 100 µM 1.24854011192373 0.111794301108553 no 385 0.10591666423891 514 16666 SGTC_278 4092-0821 23.9 µM 1.24806236885359 0.111884762095909 no 386 0.106004108935671 581 877900 SGTC_1280 0880-0253 10.1 µM 1.2433776430819 0.112774592471746 no 387 0.106864352414822 602 6836607 SGTC_2703 st077852 53.4 µM 1.2422917535145 0.112981568866928 no 388 0.107064468426697 548 6281836 SGTC_954 1189-0853 2.85 µM 1.23639927510516 0.114109434707358 no 389 0.108155092723902 612 2828194 SGTC_1662 st014054 52 µM 1.23494038102813 0.114389912692699 no 390 0.108426346682241 551 2838777 SGTC_2375 9072683 200 µM 1.22977362557981 0.115387187510094 no 391 0.109390943635999 663 16798029 SGTC_1623 st003709 20.3 µM 1.2221417740997 0.116871548590449 no 392 0.110827009046888 677 16192618 SGTC_349 k015-0014 24 µM 1.22204639100368 0.116890185419168 no 393 0.110845042091126 567 2196908 SGTC_502 l-744,832 89.3 µM 1.22160499784827 0.116976456311373 no 394 0.110928518865685 610 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_616 4092-0450 108 µM 1.21916914678538 0.117453358329471 no 395 0.11138999981426 637 787165 SGTC_2652 actinonin 100 µM 1.2182039018017 0.117642718730223 no 396 0.111573248652613 580 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_506 n9-isopropylolomoucine 153 µM 1.21760533639488 0.117760252943622 no 397 0.111686992782033 596 6610355 SGTC_3278 9139605 49.47 µM 1.217052976189 0.117868788014502 no 398 0.111792030207102 598 7958859 SGTC_2626 ethyl orsellinate 100 µM 1.21544692129366 0.118184769039016 no 399 0.112097840705775 582 75653 A natural product. SGTC_2742 clothiapine 36.27 µM 1.21447455662634 0.11837636643156 no 400 0.112283280003624 551 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2246 7293507 91.5585 µM 1.21364101391116 0.118540784669929 no 401 0.112442419042171 624 887656 SGTC_671 0560-0003 407 µM 1.21270497353826 0.118725613107811 no 402 0.112621318817855 571 3238678 SGTC_3231 9132313 49.47 µM 1.21203300500742 0.118858423987886 no 403 0.112749873416065 623 4905967 SGTC_1967 st070177 51.4 µM 1.20718166454054 0.119820378574588 no 404 0.113681095041108 588 5729214 SGTC_527 4476-4215 268 µM 1.20522949999369 0.120209010843064 no 405 0.114057358522232 631 4418754 SGTC_418 lividomycin a 100 µM 1.20405205630062 0.1204438424686 no 406 0.11428472946579 662 72394 An antibiotic. SGTC_1443 4112-3303 14 µM 1.20242032087544 0.120769812752641 no 407 0.11460035997638 628 704433 SGTC_1251 0490-5699 265 µM 1.20041022366037 0.121172221013836 no 408 0.114990030113436 684 3883818 SGTC_1761 st044296 37 µM 1.19532875796682 0.122193699816721 no 409 0.115979304070614 622 1826700 SGTC_3330 9141424 71.43 µM 1.19466464158444 0.122327646203365 no 410 0.116109041200721 664 27261020 SGTC_692 k241-0027 77.8 µM 1.18988622925288 0.123294448354058 no 411 0.117045555820622 613 3600480 SGTC_1107 amlodipine 47 µM 1.18932424249566 0.123408504374733 no 412 0.11715604962491 637 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2881 9058953 51.95 µM 1.18628191531741 0.12402723213565 no 413 0.117755493031398 651 17122249 SGTC_2983 9022671 12.99 µM 1.18279864250776 0.124738297943674 no 414 0.11844447935954 605 6405161 SGTC_1895 st058434 18.3 µM 1.18214510985447 0.124872025093098 no 415 0.11857406397947 666 5393175 SGTC_3119 9125183 49.47 µM 1.17850770631933 0.125618147953416 no 416 0.119297130959953 491 22695334 SGTC_1933 st074711 15.9 µM 1.17777995193485 0.125767801332963 no 417 0.119442171551017 679 17250958 SGTC_2489 cantharidin 73.42 µM 1.17359589070779 0.126630612779734 no 418 0.120278463974434 647 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1309 pyrazolanthrone 13.4 µM 1.17321463582108 0.126709437266473 no 419 0.120354872146799 687 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1438 4092-1045 4 µM 1.17236511195623 0.126885199283101 no 420 0.120525250141585 652 1351342 SGTC_2174 5790901 200 µM 1.171095284307 0.127148236268005 no 421 0.120780239579466 625 786020 SGTC_3314 9135860 59.4275 µM 1.17091602295959 0.127185399692445 no 422 0.12081626695674 672 25252478 SGTC_1472 k841-0093 193 µM 1.16935091554105 0.127510189749023 no 423 0.121131138600359 686 X1472 SGTC_2324 6149169 200 µM 1.16868523417019 0.127648506171894 no 424 0.121265236614023 607 2888231 SGTC_2026 5148700 152 µM 1.16795956319135 0.127799406125774 no 425 0.121411538116247 635 79838 SGTC_205 1486-1330 71.903 µM 1.16542263409542 0.128327923015513 no 426 0.121923979901615 592 4118834 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.16504095121768 0.128407569920859 no 427 0.122001208435951 632 4330530 SGTC_2884 9058502 51.95 µM 1.16500499666962 0.128415074431922 no 428 0.122008485138324 660 6471554 SGTC_3085 9117376 49.47 µM 1.16493013451435 0.128430700799876 no 429 0.122023637179367 647 16480349 SGTC_2405 ticlatone 3.52 µM 1.16420149542757 0.128582862383832 no 430 0.122171182182544 607 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2047 4141938 200 µM 1.16365591058899 0.12869687865956 no 431 0.122281741786292 594 3807862 SGTC_1713 st033146 12.748 µM 1.1636145545336 0.128705524103974 no 432 0.122290125213812 660 674619 SGTC_1417 3966-0327 90.4 µM 1.15753466774268 0.129980904983663 no 433 0.123526991958501 716 651118 SGTC_729 4092-0585 94.1 µM 1.15705585875632 0.130081715299139 no 434 0.123624769708777 603 2169061 SGTC_852 0418-0143 439 µM 1.15611264160934 0.130280462184237 no 435 0.12381754292337 737 5369229 SGTC_628 1636-0253 16 µM 1.15552698459746 0.130403972632965 no 436 0.123937344406503 692 4456143 SGTC_787 4152-0075 138 µM 1.15318330457198 0.130899046720193 no 437 0.124417577345837 640 9566539 SGTC_1216 1165-0504 9.65 µM 1.15288379166566 0.130962408679815 no 438 0.12447904283073 685 6304004 SGTC_606 k015-0008 38.6 µM 1.15023327538529 0.131524049057249 no 439 0.125023902218327 721 1970475 SGTC_1943 st076331 65.2 µM 1.14779886623335 0.132041359482739 no 440 0.125525802741166 697 24208415 SGTC_50 0929-0078 56.389 µM 1.14765917311963 0.132071086691409 no 441 0.125554645774573 641 1377751 SGTC_2121 5257820 149.641 µM 1.14734970758083 0.132136958532532 no 442 0.125618558915525 717 791256 SGTC_2980 9014342 25.29 µM 1.14237400935754 0.133199180379825 no 443 0.126649294963768 635 2996599 SGTC_559 1550-0661 158 µM 1.137218523234 0.134305966667171 no 444 0.127723472673967 667 5830875 SGTC_1882 5615643 20 µM 1.13427550331336 0.13494060185678 no 445 0.128339500693882 631 2253075 SGTC_2523 spermine 47.74 µM 1.13035050262677 0.135790188684776 no 446 0.129164281024279 665 1103 A DNA binding polyamine. SGTC_517 1365-0151 113 µM 1.12990955695542 0.135885862058604 no 447 0.129257168256491 664 768657 SGTC_1698 5-fluorocytosine 1.055 µM 1.12841770629317 0.136209895806575 no 448 0.129571776729291 681 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2585 alliin 100 µM 1.12746415059476 0.136417287310187 no 449 0.129773144702354 691 87310 A garlic compound which reacts with lipids. SGTC_584 0986-0246 15.4 µM 1.12722822679443 0.136468632355037 no 450 0.129822999544488 740 53315 YDR232W HEM1 SGTC_1866 st057638 64 µM 1.1226267535513 0.13747271298574 no 451 0.130798024019606 684 688802 SGTC_2819 7996655 46.38 µM 1.12170768133461 0.13767386513987 no 452 0.130993374747003 588 6456960 SGTC_56 0957-0365 83.25 µM 1.12010486278319 0.138025145411051 no 453 0.131334539331031 703 6752360 SGTC_1111 tnp00062 510.699 nM 1.11987010935474 0.138076646210499 no 454 0.131384558744806 698 676306 SGTC_1579 chlormadinone acetate 49.4 µM 1.11875959519987 0.138320451221801 no 455 0.131621356636623 704 45114258 A steroidal progestin. SGTC_1389 3405-0187 19 µM 1.11827430182378 0.138427085806088 no 456 0.13172492946224 632 799890 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.11802715196635 0.138481414115822 no 457 0.131777698562987 705 3256 An antibiotic and ribosome inhibitor. SGTC_3153 9100258 49.47 µM 1.11724505804149 0.138653429188248 no 458 0.131944779957069 626 25236848 SGTC_882 0843-0131 351 µM 1.11548238881364 0.139041647191908 no 459 0.132321880582602 747 5425421 SGTC_108 0509-0257 621.132 µM 1.11072510036485 0.140093104001396 no 460 0.133343347319117 738 536624 SGTC_285 1486-1325 46 µM 1.11034388811644 0.140177592774222 no 461 0.133425433882315 738 22310230 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.10950163741457 0.14036438504524 no 462 0.13360691922967 746 6708784 An antioxidant flavonoid SGTC_2118 5526350 200 µM 1.10835587851523 0.140618759857421 no 463 0.133854075911486 721 743594 SGTC_1700 st030840 7.9285 µM 1.10592613769754 0.141159231733013 no 464 0.134379245264462 740 5499307 SGTC_270 tamoxifen 5.46 µM 1.10503350979537 0.141358141317709 no 465 0.134572534648474 766 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.10468257690644 0.141436393781452 no 466 0.13464857778959 671 688662 SGTC_1677 st019204 53.9 µM 1.10395338095868 0.141599086762743 no 467 0.13480668049531 664 3945625 SGTC_1848 st056003 16.4 µM 1.10100223905777 0.142258818974253 no 468 0.135447841333906 732 146492 SGTC_273 hydroxyurea 18.1 mM 1.09943928114169 0.142609061699597 no 469 0.135788252443386 781 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_615 k087-0205 167 µM 1.09676612989052 0.143209437725327 no 470 0.136371819899743 674 9642773 SGTC_667 1498-1044 59 µM 1.09411526211921 0.143806492606184 no 471 0.136952214775623 736 6739982 SGTC_1361 1608-0041 5.61 µM 1.09224005578285 0.144229858061637 no 472 0.137363800276364 723 X1361 SGTC_856 0433-0016 11.3 µM 1.09218856513151 0.144241494949725 no 473 0.1373751137648 735 3911780 SGTC_3164 9100705 49.47 µM 1.09213109113123 0.144254484822282 no 474 0.137387742661766 659 17174235 SGTC_1137 ixabepilone 100 µM 1.08916120536256 0.144926790969623 no 475 0.138041401653059 750 154225 A novel microtubule stabilizer. SGTC_3063 1327-0034 4 µM 1.08848969267768 0.145079096201103 no 476 0.138189492208423 697 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_670 4204-0025 119 µM 1.08584780042748 0.145679346936535 no 477 0.138773167183746 755 719039 SGTC_685 1278-0033 54.9 µM 1.08527691300054 0.145809274392398 no 478 0.138899514007312 740 3590572 SGTC_2533 agelasine 13.65 µM 1.08381379664706 0.146142618458862 no 479 0.139223683368126 748 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1558 st069300 45.6 µM 1.08371377567674 0.146165425069557 no 480 0.139245862888601 650 24208000 SGTC_2504 purpurogallin 52.29 µM 1.08220183195699 0.146510467084185 no 481 0.139581427330273 690 5281571 An antioxidant. SGTC_1416 3966-0321 25.3 µM 1.08219256109463 0.14651258448098 no 482 0.139583486622786 739 582530 YLR208W SEC13 SGTC_1379 2144-0755 36.5 µM 1.08211470654144 0.146530366698976 no 483 0.139600780899249 775 5392327 SGTC_2141 5621638 7.665 µM 1.08204263785711 0.146546828697917 no 484 0.139616791226285 727 2856238 SGTC_430 0958-0115 16.4 µM 1.08053186034152 0.146892207726257 no 485 0.139952703532881 696 6833180 SGTC_247 mechlorethamine 29.705 µM 1.08027360143216 0.146951302924748 no 486 0.14001018077287 677 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3061 glucosamine 200 µM 1.07871111915297 0.147309172523288 no 487 0.140358263664545 699 91431 and experimental redox chemotherapeutic SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.07770423402964 0.147540097854821 no 488 0.14058288418101 791 91467 include heat shock SGTC_1340 1486-1359 257 µM 1.07753054099527 0.147579958214115 no 489 0.140621657076048 726 4309068 SGTC_2471 5466956 24.79 µM 1.07744187944622 0.147600307701348 no 490 0.140641451484596 715 724419 SGTC_221 trifluoperazine 10.304 µM 1.07728424420367 0.147636492585315 no 491 0.14067664949844 855 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_694 1315-0438 43.2 µM 1.07720928236796 0.147653702023115 no 492 0.140693389653019 627 6793154 SGTC_1683 st010134 710 nM 1.07518185727129 0.148119659743887 no 493 0.141146658251889 720 3818134 SGTC_338 4055-0136 114 µM 1.07438309573169 0.148303506896517 no 494 0.141325507853408 720 2900563 SGTC_2348 9022543 33.42 µM 1.07410801872122 0.148366855387676 no 495 0.141387135513992 745 3162678 YDL140C RPO21 SGTC_1454 4239-0054 42.6 µM 1.07096784814943 0.149091299290358 no 496 0.142091943298033 791 1340767 SGTC_1264 0783-0040 158 µM 1.06703409566725 0.15000215267213 no 497 0.1429782199049 694 2855798 SGTC_1310 1188-0297 994 nM 1.06421679574187 0.150656769023063 no 498 0.143615250031113 738 1588352 SGTC_2730 imipramine 71.33 µM 1.0641754610695 0.150666387518706 no 499 0.143624610603484 859 3696 A tricyclic antidepressant. SGTC_1313 1220-0047 237 µM 1.06181443800147 0.151216471668927 no 500 0.144159966992655 775 3528706 SGTC_1676 st018489 23.4 µM 1.05784082696534 0.152145278227909 no 501 0.145064008056289 738 3696235 SGTC_2640 pentamidine 10.38 µM 1.05519480158915 0.152765866833155 no 502 0.14566812058705 814 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1862 st057513 3.81 µM 1.05426839901852 0.152983537964142 no 503 0.145880026205203 733 5393163 SGTC_3284 9108171 64.8615 µM 1.05389930265139 0.153070319527062 no 504 0.145964511107942 714 8687505 SGTC_2846 9008642 19.48 µM 1.05173386425004 0.153580112390177 no 505 0.146460834752724 684 2992898 SGTC_1509 1326-1131 80 µM 1.04945471600237 0.154117888154362 no 506 0.146984443313946 725 768313 SGTC_2473 5854593 8.94 µM 1.04798690840998 0.154464882921101 no 507 0.147322319304905 727 2872951 SGTC_2619 obliquin 87.91 µM 1.04382445093011 0.155451709094939 no 508 0.148283308445122 832 6708593 A bioactive alkalod. YER133W GLC7 SGTC_343 4130-2827 29.8 µM 1.04352581066241 0.155522669641284 no 509 0.148352416570242 777 1118244 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.04203873569091 0.15587633475913 no 510 0.148696860184657 752 2724278 An inhibitor of dopamine biosynthesis. SGTC_3054 9094397 49.47 µM 1.04088263169484 0.156151652410948 no 511 0.148965011733341 769 2598354 SGTC_2784 7567673 72.73 µM 1.04072010334497 0.156190383013064 no 512 0.14900273511747 786 3471247 SGTC_305 1682-2595 20.8 µM 1.03886304777035 0.156633369733732 no 513 0.149434217079266 786 226033 SGTC_2200 6600604 21.907 µM 1.03660787036567 0.157172436393788 no 514 0.14995932193199 783 2904777 SGTC_406 estrone 100 µM 1.03639893014243 0.157222442128593 no 515 0.150008034643634 771 5870 A steroid. SGTC_2194 5927483 104.545 µM 1.03295435667637 0.158048340728492 no 516 0.150812629596611 808 760979 SGTC_1478 0453-0656 35.7 µM 1.03271707944157 0.158105336884794 no 517 0.150868159178252 783 5258496 SGTC_104 0074-0074 590.992 µM 1.03192731644803 0.15829514233419 no 518 0.151053084078969 628 3943124 SGTC_136 0097-0015 404.482 µM 1.03068355269853 0.158594361775991 no 519 0.151344620040247 833 4861337 SGTC_2463 5473429 200 µM 1.03026761412931 0.158694509228298 no 520 0.151442198725666 742 5399405 SGTC_1977 st070720 65.3 µM 1.03002834482366 0.158752137986864 no 521 0.151498349965211 722 682188 SGTC_1836 st055642 81 µM 1.02672588783693 0.159548946311954 no 522 0.152274777843765 764 8571 SGTC_445 e6 berbamine 66 µM 1.02633290118509 0.159643939103826 no 523 0.152367346982837 876 6610268 A calcium/calmodulin antagonist. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.02603035346933 0.159717096192629 no 524 0.152438638411419 796 16623 A steroid. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.02449758628821 0.160088061633365 no 525 0.152800155157267 808 688751 SGTC_1659 st012954 42.1 µM 1.02279390349103 0.160501053198966 no 526 0.153202650572166 758 24207262 SGTC_1336 1486-0901 104 µM 1.02044256795455 0.161072185171863 no 527 0.153759307057184 782 5006114 SGTC_362 0310-0100 9.03 µM 1.01794970831093 0.161679139485188 no 528 0.154350928440211 743 790235 SGTC_1911 st060208 74.3 µM 1.01554536040309 0.162265953626719 no 529 0.154922967746443 800 688783 SGTC_1493 4348-0038 111 µM 1.01499790791721 0.162399760486364 no 530 0.155053412382993 841 800424 SGTC_1398 3558-0053 112 µM 1.01398760653373 0.162646884125212 no 531 0.155294333040089 703 4532369 SGTC_1085 doxorubicin 7.67 µM 1.01232445845427 0.163054229136736 no 532 0.155691472067971 851 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_661 1304-0007 33.6 µM 1.01115623453638 0.163340751446003 no 533 0.155970829494144 776 3117130 SGTC_1394 3474-0001 65.7 µM 1.01112223770411 0.163349094511893 no 534 0.155978964102051 687 5017666 YIL048W NEO1 SGTC_2396 5342950 42.78 µM 1.01065343312692 0.163464170738241 no 535 0.156091166050741 798 1886677 SGTC_2062 5245942 200 µM 1.01011106692474 0.163597369620397 no 536 0.156221040309821 828 1376160 SGTC_2378 9074213 121.43 µM 1.00857911128169 0.16397398079682 no 537 0.156588264711695 795 657714 SGTC_889 0919-1524 82.7 µM 1.00674494422033 0.164425625992878 no 538 0.157028678990989 738 3905452 SGTC_2193 5925765 200 µM 1.00620334895053 0.164559142449669 no 539 0.157158880764469 756 877370 SGTC_26 0302-0163 425.158 µM 1.00562504903268 0.164701785041439 no 540 0.157297984840614 798 3100915 SGTC_1183 1254-0324 198 µM 1.00482397579661 0.164899508864199 no 541 0.157490808421188 806 5799357 SGTC_3168 9103419 49.47 µM 1.00405077024656 0.16509050001652 no 542 0.157677071331914 721 16649256 SGTC_1243 0416-0003 5.65 µM 1.00377693371189 0.165158175289227 no 543 0.157743072424439 749 2141977 SGTC_2964 9083345 53.42 µM 0.998968013776517 0.166349565637746 no 544 0.158905093234498 741 17741579 SGTC_740 k014-0057 261 µM 0.994786307478603 0.167390066073421 no 545 0.159920103568828 884 4012779 SGTC_2638 epoxomicin 18 µM 0.992681563005551 0.167915355973294 no 546 0.160432581293358 847 9915668 A protesome inhibitor. SGTC_3327 9140648 26.9345 µM 0.99248896761404 0.167963475746872 no 547 0.160479529278212 800 8029710 SGTC_2642 cholecalciferol 100 µM 0.992398864646277 0.167985990934043 no 548 0.160501496295321 813 9821465 A vitamin D precursor, similar to steriods. SGTC_15 0266-0086 27.098 µM 0.991490604326488 0.168213058093658 no 549 0.160723038989559 910 1712902 YIL048W NEO1 SGTC_731 3966-0296 387 µM 0.990605954018479 0.168434412426776 no 550 0.16093901461478 811 660956 SGTC_2061 5245884 80.95 µM 0.990552589117068 0.168447771207043 no 551 0.160952049002485 819 573863 SGTC_652 0437-0092 114 µM 0.98758462373642 0.169191811392238 no 552 0.161678059914272 793 3091274 SGTC_2027 5150920 200 µM 0.987181192156411 0.169293110442222 no 553 0.161776910143665 797 786715 SGTC_1327 1436-0082 2.18 µM 0.986644936461458 0.16942782102156 no 554 0.161908366362344 809 15992205 SGTC_316 k060-0003 58.6 µM 0.985455490999037 0.16972686213846 no 555 0.162200191982518 794 6152314 SGTC_2060 5238662 140 µM 0.984418147288357 0.169987939194439 no 556 0.162454979465356 762 790130 SGTC_673 1082-0474 110 µM 0.98417131663256 0.170050099045516 no 557 0.162515643190128 896 3098046 SGTC_1305 1181-0477 144 µM 0.983813964016981 0.170140117670317 no 558 0.162603496081046 812 6252086 SGTC_2350 9023895 38.85 µM 0.983024713313716 0.170339041415747 no 559 0.162797637855168 803 2997209 SGTC_1248 0469-0687 58.6 µM 0.98186950735912 0.170630469481511 no 560 0.163082069859748 827 4017482 SGTC_3002 9075603 71.4286 µM 0.981027750508174 0.170843023494193 no 561 0.163289528491975 831 20105405 SGTC_412 gemfibrozil 100 µM 0.980345047288469 0.171015538878303 no 562 0.163457912780701 775 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1805 st050013 60.3 µM 0.980079503717191 0.1710826703828 no 563 0.163523437820177 797 4037144 SGTC_2221 6807166 181.081 µM 0.979949609435244 0.171115514817494 no 564 0.163555496504392 754 674925 SGTC_3285 9112818 20.8695 µM 0.979430175048019 0.171246896767011 no 565 0.163683736801687 871 17017947 YPR165W RHO1 SGTC_303 1348-1668 34.2 µM 0.977117128003454 0.171832724839351 no 566 0.16425558455465 820 5380509 SGTC_2985 9022375 71.43 µM 0.976085285343078 0.172094473134064 no 567 0.164511101308386 829 4939335 SGTC_3157 9099274 49.47 µM 0.976029415275312 0.172108652994782 no 568 0.164524943845732 816 17217662 SGTC_3315 9136395 68.55 µM 0.975642748144998 0.172206809810779 no 569 0.164620766356286 889 16876844 SGTC_627 1391-0720 175 µM 0.974411822947086 0.172519522332469 no 570 0.164926050731186 798 997839 SGTC_988 1497-1057 103 µM 0.971551518419963 0.173247570776369 no 571 0.165636855751414 859 3533044 SGTC_3155 9099265 49.47 µM 0.970865741232692 0.173422415617582 no 572 0.165807570007103 775 25236499 SGTC_1666 st014829 29 µM 0.970392215366443 0.173543210675939 no 573 0.165925513743245 866 3858230 SGTC_2361 9034121 116 µM 0.970103805846216 0.173616809328938 no 574 0.165997376078678 797 6496917 SGTC_976 1348-1067 47.6 µM 0.969314098698129 0.173818434751652 no 575 0.166194248501151 888 5310671 YGL099W LSG1 SGTC_48 0382-0018 55 µM 0.96867074075035 0.173982804818946 no 576 0.16635474779844 805 762596 SGTC_2105 5350118 200 µM 0.966190105259506 0.174617501535345 no 577 0.166974531588388 844 2133313 SGTC_333 3486-0131 40.1 µM 0.96612979741955 0.174632950215198 no 578 0.166989617948807 884 6744690 SGTC_2333 9017922 200 µM 0.965481252724011 0.174799138673291 no 579 0.167151910768451 840 3163164 SGTC_734 2023-0417 80 µM 0.963292453833898 0.175360755406942 no 580 0.167700389592415 828 3935732 SGTC_2298 7976326 193.81 µM 0.962116216412194 0.175663034362193 no 581 0.167995614552248 778 2235818 SGTC_2283 7944793 200 µM 0.957193100627986 0.176931796062264 no 582 0.169234899396429 844 2970533 SGTC_1962 st076595 64.5 µM 0.955862087508359 0.177275810392236 no 583 0.169570957682956 851 279619 SGTC_749 1000-0129 128 µM 0.954951738366855 0.177511342772217 no 584 0.169801051810881 896 708470 SGTC_1998 st075797 76.8 µM 0.954527037027931 0.177621292235812 no 585 0.169908465110487 930 24208315 SGTC_2187 6125751 200 µM 0.954335749753073 0.177670827972291 no 586 0.169956858739798 858 874498 SGTC_1557 sumaresinolic acid 42.3 µM 0.953990574299215 0.177760236632516 no 587 0.170044206784014 787 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_190 3970-0790 3.722 µM 0.951902030264545 0.178301824546687 no 588 0.170573334901524 831 2832352 SGTC_3131 9127911 49.47 µM 0.951319299875867 0.178453119810759 no 589 0.170721156282679 811 45595681 SGTC_1290 0986-0249 10.2 µM 0.951038527854602 0.178526045981508 no 590 0.170792409062343 802 53329 SGTC_3347 9188721 44.724 µM 0.949671615863442 0.178881348219453 no 591 0.171139568285684 814 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_522 1273-0010 11.6 µM 0.948564978422997 0.179169322913118 no 592 0.171420955034793 835 5705015 SGTC_318 1488-0629 67.2 µM 0.948293087276817 0.179240120378032 no 593 0.171490134525362 814 3662576 SGTC_1457 k015-0032 57.3 µM 0.94583481907993 0.179881024831699 no 594 0.172116421549571 854 4302660 SGTC_2235 salicylic acid 500 µM 0.942762730693821 0.180683981225894 no 595 0.17290113937998 858 338 A COX inhibitor and kinase inhibitor. SGTC_1812 st052057 4.327 µM 0.94219886193588 0.180831604194209 no 596 0.173045418241514 891 3645418 SGTC_2252 omeprazole 400 µM 0.941527806910218 0.181007387425899 no 597 0.173217223107617 778 4594 A proton pump inhibitor. SGTC_2263 7948595 193.29 µM 0.941144349115083 0.181107882460412 no 598 0.173315445500536 801 2971371 SGTC_2665 lovastatin 100 µM 0.940189030310382 0.1813584004401 no 599 0.173560303797513 845 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_49 0717-0965 32.132 µM 0.939831844016527 0.181452122871512 no 600 0.173651910929832 894 5889349 YGL099W LSG1 SGTC_2344 7990960 76.95 µM 0.938532013097383 0.181793442535594 no 601 0.173985536589108 814 140813 SGTC_293 4049-0273 38.5 µM 0.936347775924059 0.182367900252046 no 602 0.174547078600664 823 1380311 SGTC_3118 9124250 49.47 µM 0.936256963262543 0.182391808652681 no 603 0.174570450376254 780 1504786 SGTC_3181 9108277 49.47 µM 0.93534631864402 0.182631663841781 no 604 0.174804926045737 834 17097298 SGTC_885 0865-0106 16.8 µM 0.935174663083306 0.182676898348062 no 605 0.174849146846717 859 2793380 SGTC_3272 9137413 49.47 µM 0.935127071418101 0.182689440895869 no 606 0.174861408362259 843 17614870 SGTC_2474 5321570 43.32 µM 0.934963828587 0.182732466821108 no 607 0.17490347038763 876 2841384 SGTC_901 1112-0062 60.1 µM 0.934035613203254 0.182977236859195 no 608 0.175142761390973 846 1908457 SGTC_2052 5265182 7.135 µM 0.93310013015954 0.18322413026902 no 609 0.17538413597002 880 1239884 SGTC_634 1611-4317 11.2 µM 0.932784087279968 0.183307587481255 no 610 0.17546572941082 928 2843522 SGTC_3262 9137218 49.47 µM 0.929833710158062 0.184087834539719 no 611 0.176228594779198 730 17650664 SGTC_3269 9137823 49.47 µM 0.929323246879441 0.184223039481586 no 612 0.176360795594461 801 17682936 SGTC_981 1488-1094 54.9 µM 0.927050576729704 0.184825744863518 no 613 0.176950137595457 818 3449522 SGTC_2192 5915882 198.485 µM 0.92313458814825 0.185867124767831 no 614 0.177968535835813 857 2876149 SGTC_3134 9127454 49.47 µM 0.921456213337825 0.186314567261133 no 615 0.178406145911441 924 24262820 SGTC_2583 asiatic acid 100 µM 0.920862835825318 0.186472916928211 no 616 0.17856102191827 863 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_489 paxilline 115 µM 0.916994451143589 0.187507282079667 no 617 0.179572773905469 840 105008 A toxic potassium channel blocker. SGTC_756 0508-1999 28.3 µM 0.91476266244465 0.18810564851895 no 618 0.180158120018237 853 6753853 SGTC_631 k072-0230 41.5 µM 0.914664291334701 0.188132049955949 no 619 0.180183947994538 926 5773147 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.911007440005042 0.189115120065256 no 620 0.181145726786998 910 5282309 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.909503132888681 0.189520439143153 no 621 0.181542302426458 771 88881 An O-methylated flavonoid and antioxidant. SGTC_1048 3161-0300 24.5 µM 0.909064320976367 0.189638772835101 no 622 0.1816580872956 934 2165101 SGTC_1511 0906-3109 28.5 µM 0.906711415712241 0.19027405187567 no 623 0.182279712509846 988 2882180 SGTC_329 k048-0121 21.3 µM 0.906055716850918 0.190451321728167 no 624 0.182453181267094 877 6832902 SGTC_2055 5235184 200 µM 0.905912492681138 0.190490056237503 no 625 0.182491085731188 871 2836034 SGTC_862 0452-0056 10.2 µM 0.905080170546122 0.190715250764148 no 626 0.182711458211212 890 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_998 3996-0085 177 µM 0.903412514538518 0.191166946050372 no 627 0.183153500278701 968 715391 SGTC_1231 0242-0792 125 µM 0.902753582715174 0.191345602581763 no 628 0.18332834565888 901 3707635 SGTC_1808 st050063 61.5 µM 0.902689395854722 0.191363011066691 no 629 0.183345382991062 894 4011993 SGTC_2045 5106652 78.05 µM 0.902084536662538 0.191527106048084 no 630 0.183505981262175 919 673349 SGTC_106 0092-0003 11.579 µM 0.899862146762242 0.192130768133336 no 631 0.184096808335405 853 1072148 SGTC_3117 9124945 49.47 µM 0.898871769882711 0.192400156224987 no 632 0.18436048314267 822 17592065 SGTC_2022 5136654 200 µM 0.898643299828776 0.192462334136753 no 633 0.184421343624405 881 1713771 SGTC_2077 5212015 200 µM 0.898542733173899 0.192489707151433 no 634 0.184448136807749 872 780900 SGTC_578 3460-0051 92 µM 0.897788530776518 0.192695067674947 no 635 0.184649150188051 1016 2876744 SGTC_2416 tofa 880 nM 0.897702832440577 0.192718410800692 no 636 0.184671999504918 818 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2439 5492030 7.2 µM 0.896228754276019 0.193120201180207 no 637 0.185065300705527 909 5722370 SGTC_3190 9110366 49.47 µM 0.896087757481582 0.193158659541083 no 638 0.185102947537722 833 17123768 SGTC_2107 5363541 170.161 µM 0.895644672438604 0.193279546081524 no 639 0.185221284367744 946 244052 SGTC_297 0986-0032 24 µM 0.893724542176507 0.193803947078028 no 640 0.185734645454521 893 2847425 SGTC_679 0422-0091 41.4 µM 0.892345671277389 0.194181060865518 no 641 0.186103840784691 962 627384 YHR062C RPP1 SGTC_21 0849-0113 22.993 µM 0.891621178307222 0.194379384791301 no 642 0.186298007336644 913 1560156 SGTC_53 0973-0023 39.979 µM 0.891220928633937 0.194489002674114 no 643 0.186405329400233 921 674768 SGTC_1058 3448-5425 97.3 µM 0.891027409748721 0.194542015910042 no 644 0.186457232858942 893 7279705 SGTC_3326 9140064 16.379 µM 0.890613158232244 0.194655526967897 no 645 0.186568368827451 916 1868434 SGTC_2407 paclitaxel 400 µM 0.889926815222678 0.194843683800286 no 646 0.186752592135931 924 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_151 3013-0144 2.285 µM 0.888904757877013 0.195124079631214 no 647 0.187027134098241 919 906558 YHR107C CDC12 SGTC_2307 7538926 6.34 µM 0.886899134748977 0.195675023732568 no 648 0.187566603774878 919 96582 SGTC_950 1165-0508 94.1 µM 0.886880164923927 0.195680239242369 no 649 0.187571710837465 846 6148369 SGTC_414 piperonyl butoxide 100 µM 0.886771408107924 0.195710142161147 no 650 0.187600992041884 905 5794 A potent inhibitor of cytochrome P450. SGTC_683 panaxydol 45 µM 0.886511904812841 0.195781504351144 no 651 0.187670870970477 951 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1461 k072-0203 53.8 µM 0.886111322281978 0.195891693670359 no 652 0.187778771215387 882 5418714 SGTC_214 4373-3496 70 µM 0.885819570287298 0.195971970358943 no 653 0.187857381158027 1074 3779166 SGTC_711 k292-0785 179 µM 0.884360617642483 0.196373706174599 no 654 0.188250787607919 979 4146315 SGTC_2268 7933382 153.85 µM 0.883327940900406 0.196658364542807 no 655 0.188529555802038 1044 935025 YOR257W CDC31 SGTC_307 1501-1223 22.3 µM 0.88044297566079 0.19745493159381 no 656 0.18930969201712 917 2830329 SGTC_872 0588-0139 234 µM 0.878128004923808 0.19809552630597 no 657 0.189937128381959 981 2047100 SGTC_2589 lobaric acid 100 µM 0.877308609798505 0.198322568268936 no 658 0.190159518507717 916 73157 A novel microtubule depolymerizer. SGTC_3073 9114972 49.47 µM 0.877286421912488 0.198328718378683 no 659 0.190165542694317 864 41905075 SGTC_911 3456-4043 236 µM 0.876784967417818 0.198467743844897 no 660 0.19030172282836 967 914281 SGTC_353 1988-1175 58.3 µM 0.875933669518731 0.198703896036967 no 661 0.190533047159628 883 2788357 SGTC_3045 9092950 49.47 µM 0.87445954469476 0.199113222504331 no 662 0.190934021183991 967 44120432 SGTC_59 0330-0160 1.33 µM 0.873637301104128 0.199341758884964 no 663 0.191157902892976 1027 4293482 SGTC_663 1486-0733 13.9 µM 0.87311771648602 0.199486254898535 no 664 0.191299459120911 940 722445 YPR165W RHO1 SGTC_1960 st011366 51.8 µM 0.872994308327672 0.199520583859315 no 665 0.191333090020957 982 3972846 SGTC_1665 st014639 11.4 µM 0.871216194372616 0.200015603813865 no 666 0.191818059595595 1004 981133 YIL048W NEO1 SGTC_2944 9067346 25.62 µM 0.870864521228995 0.200113595627734 no 667 0.191914065336238 877 6473075 SGTC_801 0866-0028 10.1 µM 0.870831500086054 0.200122798271873 no 668 0.191923081522084 979 6849771 SGTC_655 k060-0012 42 µM 0.867723249121356 0.200990173489748 no 669 0.192772927599446 919 5994525 SGTC_2315 7733312 200 µM 0.867175065094962 0.201143380991989 no 670 0.192923048127045 887 726316 SGTC_2167 5876490 200 µM 0.867012277297635 0.201188890714782 no 671 0.192967641410164 962 686534 SGTC_3166 9102297 49.47 µM 0.865172507199855 0.201703654579098 no 672 0.193472056394822 948 25237072 SGTC_575 k072-0246 11.9 µM 0.862607054782475 0.202422778324082 no 673 0.194176775114113 979 6796779 SGTC_1694 st024011 44.9 µM 0.862501607912047 0.202452368973962 no 674 0.194205774327576 1011 2787533 SGTC_1466 k213-0079 57.5 µM 0.862207631795721 0.20253487862272 no 675 0.19428663537743 966 3657981 SGTC_1446 4239-0190 62 µM 0.857556547516854 0.203842961598829 no 676 0.195568688761038 983 1340085 SGTC_3261 9137475 49.47 µM 0.855514314605 0.204418911755364 no 677 0.196133241610569 795 17027690 SGTC_767 0929-0023 86 µM 0.855255490134935 0.204491974483025 no 678 0.196204861291579 1015 1204563 SGTC_1328 1441-0025 69.2 µM 0.854591000204431 0.204679622364074 no 679 0.196388805833362 917 4562601 SGTC_11 0438-0307 1.3 µM 0.85166322280475 0.20550762789345 no 680 0.197200519201455 967 4011476 SGTC_2195 6536160 144.242 µM 0.851502214214367 0.205553220397347 no 681 0.197245216927249 912 3834386 SGTC_2069 5228469 200 µM 0.849091199934338 0.206236660800135 no 682 0.19791527337265 924 2835210 SGTC_3234 9132280 49.47 µM 0.848816458552161 0.206314626020472 no 683 0.197991715227962 956 17612295 SGTC_530 4358-1714 28 µM 0.846405754929742 0.206999476429434 no 684 0.198663214577885 1004 1564641 SGTC_1068 loratadine 26.9 µM 0.843897768445018 0.207713389407997 no 685 0.199363267653618 937 3957 A H1 histamine antagonist. SGTC_361 000s-0510 1.45 µM 0.843673697636685 0.207777243173208 no 686 0.199425884627841 951 660 SGTC_441 propafenone 146 µM 0.841530124949825 0.208388685787181 no 687 0.200025507922998 990 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2046 4110841 106 µM 0.840977634193635 0.208546452663405 no 688 0.200180232114234 1003 44119630 YMR134W ERG29 SGTC_203 k066-0004 30.888 µM 0.839941527493034 0.208842508618734 no 689 0.200470586068451 1106 6795412 SGTC_2295 7971645 200 µM 0.839255984929694 0.209038530828554 no 690 0.200662838453314 951 2978226 YKL099C UTP11 SGTC_167 3672-0051 66.205 µM 0.839075993267408 0.209090015117462 no 691 0.200713333347046 946 3237971 SGTC_561 1550-0330 72.9 µM 0.838231595752296 0.20933164377485 no 692 0.200950322586663 951 6812934 SGTC_2918 7977171 22.06 µM 0.836101447058382 0.209941926398233 no 693 0.201548917192196 980 2236483 SGTC_17 0960-0276 49.807 µM 0.835787305598805 0.210032015579974 no 694 0.201637284612937 1049 6821114 SGTC_633 0437-0093 97.7 µM 0.835686497961566 0.210060929909277 no 695 0.201665646535797 1011 2831118 SGTC_1727 st034309 9.9045 µM 0.835305100386719 0.210170346104942 no 696 0.201772973206884 1054 870305 SGTC_590 k048-0076 22.4 µM 0.835152724234642 0.210214069475858 no 697 0.201815861973753 966 6832814 SGTC_2014 4013930 200 µM 0.833810423509462 0.210599464911608 no 698 0.202193910315318 1032 64556 SGTC_2171 5739187 198.077 µM 0.830937149232476 0.211425818900772 no 699 0.203004567957796 972 2262761 SGTC_3027 9089541 49.47 µM 0.830231751201553 0.211628981393867 no 700 0.203203883343361 998 9943819 SGTC_2655 perillic acid 100 µM 0.829759176307662 0.211765152129609 no 701 0.203337478160828 975 5702197 An apoptosis inducer. SGTC_545 4218-0007 221 µM 0.828546905561563 0.212114697903614 no 702 0.203680421278104 955 2840508 SGTC_735 3076-0345 636 µM 0.828163166750904 0.212225415289716 no 703 0.203789050187469 1031 2888990 SGTC_704 1310-0270 142 µM 0.827775660980067 0.212337253802458 no 704 0.203898780486796 1043 5718033 SGTC_1362 1611-0397 101 µM 0.826220292181692 0.212786497108868 no 705 0.204339569606368 1015 27816 SGTC_469 w7 172 µM 0.825828535881041 0.212899737041352 no 706 0.204450682113186 1018 45115570 A P450 inhibitor. SGTC_732 3970-1727 52.7 µM 0.825466498013374 0.213004417913205 no 707 0.204553397647753 1007 1275699 SGTC_107 0358-0022 2.6945 µM 0.825424574034609 0.213016541896208 no 708 0.204565294088388 922 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2420 aureobasidin a 50 nM 0.825206133336521 0.213079719210925 no 709 0.204627285963056 1022 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1764 st044502 93.5 µM 0.824768556565105 0.213206307830344 no 710 0.204751500669581 1001 8407 SGTC_210 3551-0445 56.827 µM 0.824573514624289 0.213262746549025 no 711 0.204806881578187 1002 2865180 YOR207C RET1 SGTC_2531 methyl deoxycholate 70.07 µM 0.824383553609341 0.213317723388316 no 712 0.204860828352862 975 16667744 Haematoxylin. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.821712018666418 0.214091770259542 no 713 0.205620408629339 987 756377 SGTC_3116 9124943 49.47 µM 0.821300540878894 0.21421113636949 no 714 0.205737549849869 960 41905195 YPL160W CDC60 SGTC_1553 gossypol 38.6 µM 0.819700799343777 0.214675575145143 no 715 0.20619334711277 942 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_438 sphingosine 6.67 µM 0.818333810736007 0.215072904104745 no 716 0.206583302472808 966 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2320 7373003 200 µM 0.817748643993059 0.215243119113394 no 717 0.206750364067438 1041 5415828 SGTC_2807 7945238 51.95 µM 0.816070908198162 0.21573157699897 no 718 0.207229790788445 1007 17148797 SGTC_2402 5553605 200 µM 0.815941458593517 0.215769291785814 no 719 0.207266809373043 1035 6758546 SGTC_583 1488-1091 88.9 µM 0.81423414374348 0.216267070765537 no 720 0.207755414433796 1163 4303273 SGTC_2936 9038235 15.59 µM 0.812849943027813 0.216671131243833 no 721 0.208152048561492 1041 4749415 SGTC_1359 1582-0056 520 nM 0.812496243244227 0.216774449348435 no 722 0.208253470677222 1055 3661189 SGTC_159 3970-0959 50 µM 0.812111382195725 0.216886902226337 no 723 0.208363861287542 1175 6615653 SGTC_2424 5537928 59.2 µM 0.811352300272093 0.217108797843929 no 724 0.208581691708685 1073 5382802 SGTC_3305 9127027 53.8275 µM 0.811213743808936 0.21714931496487 no 725 0.208621467135877 1007 41905295 SGTC_3335 9143315 29.6265 µM 0.810822594843215 0.217263719557447 no 726 0.208733778460927 996 4899691 SGTC_114 0364-0001 490.298 µM 0.810509085753086 0.217355440900152 no 727 0.208823822625582 1014 4003655 SGTC_2370 9071495 200 µM 0.809330475237585 0.21770045938319 no 728 0.209162540630008 942 21791103 SGTC_2481 5478948 45.16 µM 0.807398490927607 0.218266698367858 no 729 0.209718468045335 1003 77792 SGTC_2743 auranofin 4.32 µM 0.806740609963945 0.218459708058983 no 730 0.209907971042306 1003 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2131 toluylene red 5.2905 µM 0.805730729619771 0.21875617879915 no 731 0.21019906340256 994 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1284 0929-0043 16 µM 0.805666883820633 0.218774929799571 no 732 0.210217474561977 1024 1239883 SGTC_1891 st059073 26.2 µM 0.804833416918733 0.219019797193907 no 733 0.210457907581561 1107 688754 SGTC_1006 4099-6547 255 µM 0.804574113556563 0.219096011045213 no 734 0.210532742608481 1019 3146833 SGTC_1660 st012960 28.1 µM 0.804073741697485 0.219243122295332 no 735 0.210677194209874 992 24207266 SGTC_2863 9028737 58.44 µM 0.80395322217643 0.219278563980605 no 736 0.210711995496819 1027 6460917 SGTC_665 3914-0008 307 µM 0.802566974939326 0.219686460270731 no 737 0.211112531473149 1039 1069549 SGTC_2095 5432005 200 µM 0.802451083838411 0.219720580367527 no 738 0.211146036720383 1003 783734 SGTC_2290 7904846 200 µM 0.800166946107573 0.220393685792146 no 739 0.211807038935945 1038 2962154 SGTC_2737 bleomycin 30.5 nM 0.798533409107385 0.220875791757416 no 740 0.212280506759141 1093 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_401 neomycin 50 µM 0.797788490531199 0.221095839951809 no 741 0.212496620733198 1000 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2828 7998861 71.43 µM 0.795221330408601 0.22185513679869 no 742 0.21324238301063 970 2988188 SGTC_699 0375-0592 111 µM 0.79458023299949 0.222044988297031 no 743 0.213428860259893 1096 762578 SGTC_1169 aniline yellow 25.8 µM 0.793900175768065 0.22224647850551 no 744 0.213626773680825 1018 6051 A DNA damaging agent. SGTC_865 0488-0499 301 µM 0.793795771908036 0.222277420954095 no 745 0.213657167242897 1094 9634651 SGTC_295 k015-0027 31 µM 0.793471491218008 0.222373544553333 no 746 0.21375158637872 1016 3887424 SGTC_1086 cerivastatin 2.18 µM 0.792916622327499 0.222538074317262 no 747 0.213913201046625 1039 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.791318501639214 0.223012336836301 no 748 0.214379077258558 1074 4213774 SGTC_3010 9080089 71.4286 µM 0.790648197225254 0.223211429371205 no 749 0.214574656590801 1046 17027233 SGTC_2763 lisinopril 49.32 µM 0.787769823013944 0.224067507723633 no 750 0.215415677741857 1017 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1645 Cervolide 78 µM 0.785445555026513 0.22476014423064 no 751 0.216096190096452 1004 23173 A fragrance. SGTC_2044 5102272 200 µM 0.7842551462462 0.225115358056775 no 752 0.216445206334215 1008 592666 SGTC_1609 st001574 46.4 µM 0.781819562520274 0.225843117928733 no 753 0.217160311310544 1091 3960012 SGTC_366 0181-0206 4.31 µM 0.780051184868467 0.226372347258824 no 754 0.217680373922205 1075 274874 SGTC_687 k029-0044 34.9 µM 0.779895467809556 0.22641898284572 no 755 0.217726203189321 1103 5829338 SGTC_1562 morin hydrate 59.1 µM 0.779818527847095 0.226442027540754 no 756 0.217748849532902 1047 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1769 st044406 64.4 µM 0.779014768305372 0.226682844984973 no 757 0.217985507624391 1063 670903 SGTC_135 0933-0004 26.348 µM 0.778850130506074 0.226732190569087 no 758 0.218034001692878 1006 21230617 YGL099W LSG1 SGTC_1681 tripelennamine 100 µM 0.778512590956209 0.226833377576017 no 759 0.218133443420681 1039 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1167 k781-0610 148 µM 0.778472618867003 0.226845362024768 no 760 0.218145221234061 1072 4525169 SGTC_1187 1391-0724 117 µM 0.77622002112404 0.227521313823267 no 761 0.21880954332871 1084 6997986 SGTC_282 k297-0036 65.7 µM 0.775370954628669 0.227776392838575 no 762 0.219060246496426 1050 5061378 SGTC_1140 3229-1848 2.98 µM 0.773345796411213 0.228385446019788 no 763 0.21965887969849 1098 2849525 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.773240303811978 0.228417197291155 no 764 0.219690088844616 1025 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1524 corynanthine 62.1 µM 0.773179434710529 0.22843551886451 no 765 0.219708097642258 1050 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3236 9132701 49.47 µM 0.773099241923725 0.22845965811932 no 766 0.219731824860049 1050 24282524 SGTC_995 3931-2021 34.6 µM 0.772440944272622 0.228657869937423 no 767 0.219926655727826 1034 730143 SGTC_3052 9092717 49.47 µM 0.771340937716674 0.228989294632321 no 768 0.220252436622359 1074 25237534 SGTC_1737 st035557 69.7 µM 0.770733100702585 0.22917254745713 no 769 0.220432573896645 950 5716916 SGTC_2689 tacrolimus 100 µM 0.770687033555809 0.229186439293377 no 770 0.220446229698937 1055 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_871 0574-0004 149 µM 0.770626188559516 0.229204788206332 no 771 0.22046426688008 1037 9551173 SGTC_1124 fisetin 1.16336 µM 0.770448576827102 0.229258354959753 no 772 0.220516923787575 1022 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.770388642800347 0.229276432327146 no 773 0.220534694175153 1068 442882 SGTC_3216 9129716 49.47 µM 0.769215045350442 0.229630575090313 no 774 0.220882830122849 1048 8056934 SGTC_146 3448-8650 53.125 µM 0.769214659813121 0.229630691479722 no 775 0.220882944540313 1122 2891488 YIL048W NEO1 SGTC_2499 avocadenofuran 51.48 µM 0.768593446044737 0.229818271893708 no 776 0.221067348723105 1057 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1205 4161-2785 76 µM 0.767665845730348 0.230098527783008 no 777 0.221342866132877 985 3498106 SGTC_2594 a-mangostin 100 µM 0.763165716362152 0.231460862514173 no 778 0.22268228602414 1091 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1931 st074438 57.1 µM 0.760783227485137 0.232183935771637 no 779 0.223393277034858 1089 2787313 SGTC_250 brefeldin a 552.239 µM 0.760441042988937 0.232287890169992 no 780 0.223495498952057 1004 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1016 4226-1401 38 µM 0.75987950464925 0.232458539566366 no 781 0.223663306821886 1121 2901613 SGTC_1559 coumarin 343 70.1 µM 0.757203226585996 0.233272807682335 no 782 0.224464058724305 1076 108770 A hepatotoxic, DNA x-linker. SGTC_2862 9027634 71.43 µM 0.756719465035108 0.233420162775576 no 783 0.224608975315674 1070 5012562 SGTC_3021 9087658 49.47 µM 0.755992487825859 0.233641699099146 no 784 0.224826849858135 1098 25237042 SGTC_3356 9151811 4.48 µM 0.755838918906836 0.233688512028311 no 785 0.224872889676616 1071 1859254 YPR165W RHO1 SGTC_1399 3562-5772 25 µM 0.75547605487941 0.233799145744187 no 786 0.224981697205322 1028 23847490 SGTC_2326 6164455 177.58 µM 0.754515279440218 0.234092216973741 no 787 0.225269937050441 1059 2888790 SGTC_2184 6075246 200 µM 0.752811219408059 0.234612516926872 no 788 0.225781681922798 1074 2267320 SGTC_3096 9117468 49.47 µM 0.752422431191307 0.234731315017068 no 789 0.225898530652136 1021 41316311 SGTC_3199 9111318 49.47 µM 0.751030444871762 0.235156922803061 no 790 0.226317166785484 1050 8548020 SGTC_2444 5485484 36.41 µM 0.750702248716202 0.235257332708631 no 791 0.226415934699426 1136 6790631 SGTC_3202 9113761 49.47 µM 0.749979972649903 0.235478392661324 no 792 0.226633383406943 1133 4798415 SGTC_3125 9127534 49.47 µM 0.748291541330341 0.235995601147351 no 793 0.227142162737379 1010 1639235 SGTC_1133 3473-0247 50 µM 0.747290536958832 0.236302529009662 no 794 0.22744410169677 1074 711311 SGTC_2772 vinpocetine 57.06 µM 0.746528431094499 0.236536353129002 no 795 0.227674131767583 1104 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2711 st079103 59.1 µM 0.746394886340155 0.236577339525014 no 796 0.227714453702946 1116 54693780 SGTC_3322 9139058 2.11 µM 0.746323530329866 0.236599241093599 no 797 0.227736000280933 1101 4908926 YPR165W RHO1 SGTC_449 xestospongin c 11.1929 µM 0.744424231280497 0.237182609929322 no 798 0.228309932018189 1089 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1613 st002381 52.1 µM 0.744405289326607 0.237188431918659 no 799 0.228315660004522 1141 551167 SGTC_696 1560-0013 611 µM 0.743691174923004 0.237407979020296 no 800 0.228531664830534 1141 1650269 SGTC_1505 k297-0037 20.6 µM 0.743575215889635 0.237443639954719 no 801 0.22856675086841 1126 4089396 SGTC_1092 toremifene 6.32 µM 0.741408058225591 0.238110647683542 no 802 0.229223030010001 1158 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2833 9001315 45.46 µM 0.740857467010802 0.238280272062698 no 803 0.229389933411691 1098 2989378 SGTC_1545 lovastatin 49.4 µM 0.740735816996836 0.238317758535424 no 804 0.229426818959578 1166 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2986 9022445 71.43 µM 0.740423196106634 0.238414107531104 no 805 0.229521624106974 1099 6459286 SGTC_1784 st039334 36.3 µM 0.73903442147045 0.238842382216359 no 806 0.229943047981807 1139 3496984 SGTC_730 1436-0052 41.2 µM 0.738453733806402 0.239021581180534 no 807 0.230119386065626 1165 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2070 5230947 200 µM 0.738430479349655 0.239028758986256 no 808 0.230126449348192 1213 2835538 SGTC_1885 st057546 99.9 µM 0.738428990030729 0.239029218688901 no 809 0.230126901716382 1154 702008 SGTC_264 promethazine 12.5 mM 0.737847101240981 0.239208865160965 no 810 0.230303683642959 1203 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_180 1486-1293 102.781 µM 0.736984571997165 0.239475289408693 no 811 0.230565865781842 1141 4140536 SGTC_335 4077-0256 27.6 µM 0.736930487179287 0.239492000913803 no 812 0.230582311444632 1168 3121989 SGTC_2377 9073351 62.6 µM 0.735620302795337 0.239897025328427 no 813 0.230980901661128 1108 7337946 YHR072W ERG7 SGTC_24 0417-1663 219 µM 0.734820148686949 0.240144564950076 no 814 0.23122451722112 1120 4329390 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.732779770319556 0.240776416143643 no 815 0.231846380798869 1006 6708630 An antioxidant. SGTC_881 0833-0569 170 µM 0.731169025070034 0.2412758595965 no 816 0.232337958686343 1118 5418700 SGTC_1011 4112-3381 17.4 µM 0.729221562136162 0.241880460085666 no 817 0.232933071835739 1168 2877139 SGTC_244 nsc-207895 1.295 µM 0.72767509991259 0.242361152627922 no 818 0.233406248160817 1030 42640 SGTC_148 3253-0744 288.01 µM 0.727319439375418 0.242471777066675 no 819 0.233515146203289 1148 6893655 SGTC_1034 k072-0165 12.7 µM 0.726617007527895 0.242690341375839 no 820 0.233730303299303 1154 5835461 SGTC_87 0100-0052 35.5 µM 0.724292122790825 0.243414498076899 no 821 0.234443205994262 1239 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_548 1436-0017 110 µM 0.722773035061998 0.243888294478724 no 822 0.234909668190431 1207 9677137 SGTC_2000 st075254 36.4 µM 0.722334829942623 0.244025061043529 no 823 0.235044321915016 1108 17234175 SGTC_7 0192-1582 4.227 µM 0.721893984829303 0.244162693301683 no 824 0.235179829884103 1193 252616 SGTC_2518 prenyletin 46.28 µM 0.721203751846639 0.244378268732572 no 825 0.235392081888606 1078 3873459 A coumarin with calcium channel inhibitory activity. SGTC_179 1273-0063 6.77 µM 0.721174601692695 0.244387375244301 no 826 0.235401048113661 1138 3108139 SGTC_1100 amiodarone 5.07 µM 0.720726777727964 0.244527298488249 no 827 0.235538816888279 1180 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_942 3253-1115 227 µM 0.720245514648677 0.244677717928016 no 828 0.235686922465893 1181 46497897 SGTC_3205 9113483 49.47 µM 0.720199914504572 0.244691972899632 no 829 0.235700958276499 1151 17018033 SGTC_2940 9060638 45.86 µM 0.719759805839849 0.244829577388635 no 830 0.235836448247805 1137 4027022 SGTC_2112 5488546 200 µM 0.717678398681909 0.245480914586034 no 831 0.236477802697511 1153 600757 SGTC_3108 9121785 49.47 µM 0.716960812795809 0.245705685210316 no 832 0.236699138361393 1138 17140271 SGTC_2484 5809818 12.04 µM 0.715884575913975 0.246043003740161 no 833 0.237031311578691 1144 2870548 SGTC_1368 1852-0141 284 µM 0.715028620885744 0.246311457896816 no 834 0.237295679088431 1146 2838987 SGTC_38 0929-0051 58.268 µM 0.713193933626164 0.246887401540708 no 835 0.237862879814397 1179 1379719 SGTC_1286 0929-0070 131 µM 0.70979364179744 0.247956721595451 no 836 0.238916056260074 1212 1420408 SGTC_415 dibenzyl ketone 100 µM 0.709032226570992 0.248196508863937 no 837 0.239152239263059 1158 7593 SGTC_1482 3346-2049 8.48 µM 0.706644721331635 0.248949190609991 no 838 0.239893644950965 1167 3826804 SGTC_2974 9094440 9.66 µM 0.705986906103285 0.249156785820517 no 839 0.240098140155872 1184 25236134 SGTC_1144 3486-0183 12.5 µM 0.70510258523939 0.249436007349647 no 840 0.240373198908659 1187 6744069 SGTC_2505 galangin 7.89 µM 0.70498802244645 0.249472192354729 no 841 0.240408845021668 1084 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_311 1315-0136 58 µM 0.703460098317981 0.249955058395084 no 842 0.240884532446736 1195 6759207 SGTC_444 curcumin 90.4 µM 0.70317787051649 0.250044304380142 no 843 0.240972454197209 1137 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1638 st008370 60.6 µM 0.702652780544241 0.250210393141388 no 844 0.241136080650687 1201 24207134 SGTC_476 mead acid 10 µM 0.702547383980579 0.250243737685985 no 845 0.241168931186691 1192 5312531 An omega 9 fatty acid. SGTC_2787 5284540 71.43 µM 0.701240434216508 0.250657415981956 no 846 0.241576489970775 1186 736958 SGTC_2104 5389443 200 µM 0.699787220342593 0.251117815012995 no 847 0.242030098455857 1219 2244536 SGTC_1925 st057770 10.1 µM 0.698576731687529 0.251501656428401 no 848 0.242408294660941 1136 5989122 SGTC_2639 lactacystin 53 µM 0.698414209973277 0.251553215050913 no 849 0.242459096122441 1209 3870 A proteasome inhibitor. SGTC_697 0508-1955 564 µM 0.696778692301393 0.252072379738529 no 850 0.242970651404243 1192 6243113 SGTC_2798 7813637 45.45 µM 0.693019741311318 0.253267728056795 no 851 0.244148581365787 1179 956368 SGTC_378 3970-0959 8.33 µM 0.692366048210799 0.253475906588133 no 852 0.244353740862703 1191 6615653 SGTC_2210 7115885 190.385 µM 0.68820586135629 0.254802885639768 no 853 0.245661576688625 1224 2927039 SGTC_1923 st058458 19.1 µM 0.686912597313111 0.255216139128703 no 854 0.246068904034088 1253 3534982 SGTC_1730 st033808 45.1 µM 0.68618614859798 0.255448424360724 no 855 0.246297865638514 1211 1045166 SGTC_1624 st003710 6.25 µM 0.684141567310816 0.256102780899669 no 856 0.24694288795553 1228 24207033 SGTC_2178 5812956 200 µM 0.683143737041195 0.256422447908659 no 857 0.247258010312455 1211 5403383 SGTC_2310 7668677 200 µM 0.68000259048938 0.25743010800159 no 858 0.248251410323728 1249 2197143 SGTC_493 zm226600 134 µM 0.678158585270122 0.258022610238036 no 859 0.248835574111806 1247 5240098 A potassium channel opener. YCR052W RSC6 SGTC_913 3487-1245 167 µM 0.67771805294476 0.258164263453886 no 860 0.248975238889486 1185 4016153 SGTC_3287 9117173 37.0625 µM 0.676999616586061 0.2583953632034 no 861 0.249203098816739 1200 2789709 SGTC_286 k060-0067 22.9 µM 0.676612123614459 0.258520052722841 no 862 0.249326042461945 1195 5985051 SGTC_2987 9018338 71.43 µM 0.675939212009309 0.258736659769479 no 863 0.249539620235149 1279 5055682 SGTC_3033 9090887 49.47 µM 0.674446004270008 0.259217651524678 no 864 0.250013901635543 1232 19325384 SGTC_2286 7945697 125 µM 0.673640918012913 0.259477177369698 no 865 0.250269816180926 1199 1245733 SGTC_1760 st045453 10.4495 µM 0.672051641079017 0.259989886852655 no 866 0.25077541058985 1250 3323419 YIL048W NEO1 SGTC_878 0828-0289 13.7 µM 0.67105601337149 0.260311347787955 no 867 0.251092423523365 1241 745350 YLR208W SEC13 SGTC_2817 7995342 71.43 µM 0.671028841443611 0.260320123729472 no 868 0.25110107817445 1199 18879975 SGTC_608 k048-0125 159 µM 0.669879815208852 0.260691373665152 no 869 0.251467203994005 1255 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2346 9031566 143.75 µM 0.668241874951193 0.261221062188259 no 870 0.251989604731055 1200 4771086 SGTC_1791 st048313 56.1 µM 0.664590556492882 0.262403838256672 no 871 0.253156205501238 1190 1204976 SGTC_558 k064-0027 21.3 µM 0.662916697805975 0.262946968596528 no 872 0.25369195344365 1265 5088526 SGTC_3047 9092122 49.47 µM 0.661628188380278 0.263365452699654 no 873 0.254104768785509 1215 17173831 SGTC_1091 telmisartan 47.6 µM 0.66074985075781 0.263650915349845 no 874 0.254386374254285 1308 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2365 9042475 200 µM 0.659769697019647 0.263969654824789 no 875 0.25470081617735 1273 6464479 SGTC_543 3844-1095 191 µM 0.658675287178721 0.264325781544955 no 876 0.255052152809719 1257 4230703 SGTC_1849 st056239 19.2 µM 0.656210855854996 0.265128615071681 no 877 0.255844232484734 1194 5393181 SGTC_2427 5545055 42.75 µM 0.656028351170047 0.265188118523105 no 878 0.255902941355899 1277 5372858 SGTC_716 1683-5115 658 µM 0.654799140886782 0.265589064283936 no 879 0.256298541924746 1283 723597 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.65404260911651 0.265835983773278 no 880 0.256542177274949 1191 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2682 pyrogallin 40.03 µM 0.653204862416803 0.266109546160171 no 881 0.256812107970581 1269 822798 An ATP competetive kinase inhibitor. SGTC_72 0744-0168 198.391 µM 0.653098653921389 0.266144238242319 no 882 0.256846340007479 1207 677577 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.652028263270666 0.266493999838846 no 883 0.257191469904958 1275 5377381 SGTC_2198 6589944 200 µM 0.650335767740126 0.267047514901857 no 884 0.257737678941579 1235 5290268 SGTC_2441 5730946 39.09 µM 0.649122869170607 0.267444538972388 no 885 0.258129480555077 1287 1774275 SGTC_937 3122-0005 46.7 µM 0.648710882422336 0.267579464327747 no 886 0.258262634520214 1258 759535 SGTC_2293 7624732 200 µM 0.643698697607829 0.269223694615666 no 887 0.259885417319007 1247 894453 SGTC_925 2064-1272 59.6 µM 0.642148760020586 0.269733170381446 no 888 0.260388299490094 1257 6815817 SGTC_3007 9078383 71.4286 µM 0.639044930649393 0.270754871212996 no 889 0.261396851552994 1264 6496995 SGTC_2461 5755302 26.15 µM 0.638542115525968 0.270920566692023 no 890 0.261560423908319 1335 2788904 SGTC_3195 9113082 49.47 µM 0.638036702665956 0.271087169193346 no 891 0.261724894275532 1256 17018038 SGTC_3334 9142812 21.919 µM 0.63798498883714 0.271104218837447 no 892 0.261741725870529 1319 45283678 SGTC_315 k915-0449 187 µM 0.637623657059576 0.271223362012884 no 893 0.261859346080485 1325 20970215 YNL149C PGA2 SGTC_2288 7946289 167.31 µM 0.637269682586523 0.271340104544322 no 894 0.261974597631057 1336 1246052 SGTC_1521 st012942 49.4 µM 0.634554251904893 0.272236499024643 no 895 0.262859586545594 1346 24207259 SGTC_1392 3455-1037 33.9 µM 0.634017280595939 0.272413933468846 no 896 0.263034772307523 1306 981132 SGTC_2035 5154463 94.595 µM 0.633914781037166 0.272447809500845 no 897 0.263068219354345 1296 2769623 SGTC_1062 mesoridazine 14.2 µM 0.633585185733647 0.272556754694363 no 898 0.263175785664093 1298 4078 A neuroleptic. SGTC_1366 1683-0113 21.9 µM 0.632647083757457 0.272866955423484 no 899 0.263482066389444 1294 708623 SGTC_2736 butenafine 14.65 µM 0.631759011512223 0.27316077415128 no 900 0.26377218046142 1277 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_644 1498-1197 63.3 µM 0.630593230287475 0.27354671072294 no 901 0.264153263197026 1335 6741615 SGTC_855 0428-0020 25 µM 0.629895925127356 0.273777685319525 no 902 0.264381339554722 1285 6812414 SGTC_2888 9058547 12.99 µM 0.628100935486453 0.274372699068865 no 903 0.264968910151082 1231 16476514 SGTC_3215 9129942 49.47 µM 0.627978908038087 0.274413172608443 no 904 0.265008878601398 1248 17682944 SGTC_3342 9147791 14.508 µM 0.627092559845195 0.274707241172871 no 905 0.265299281936067 1260 1838168 SGTC_2352 9027995 87.8 µM 0.626109259503249 0.275033657794798 no 906 0.265621639604899 1296 2997347 SGTC_491 tetrandrine 80.3 µM 0.625746811970633 0.275154024139938 no 907 0.265740511718155 1339 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1670 st016595 4.04 µM 0.624234900175456 0.27565639929965 no 908 0.266236664963891 1295 597879 SGTC_3086 9117350 49.47 µM 0.623668532496398 0.275844706901357 no 909 0.266422646437298 1238 2679265 SGTC_1164 k060-0068 93.7 µM 0.623414894528103 0.275929057688934 no 910 0.266505956326457 1324 5963676 SGTC_3177 9107506 49.47 µM 0.622941330233602 0.276086581898391 no 911 0.266661538442588 1255 8897194 SGTC_3270 9137563 49.47 µM 0.621400153117342 0.276599537279098 no 912 0.26716818566868 1316 17015724 SGTC_1568 digitonin 820 nM 0.619810318148694 0.27712917664259 no 913 0.267691337363423 1353 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_427 1354-0053 47.3 µM 0.618821549619565 0.277458826176241 no 914 0.2680169620948 1387 6813657 SGTC_2411 st077133 39.94 µM 0.618733058489278 0.277488337933512 no 915 0.268046114024653 1450 1403142 YNL221C POP1 SGTC_564 3555-0129 330 µM 0.618725822866138 0.277490751078844 no 916 0.268048497750848 1228 563260 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.618220164414639 0.277659418115912 no 917 0.26821510987192 1345 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2469 5655019 90.81 µM 0.618068390034573 0.277710053629209 no 918 0.26826512899375 1409 2788239 SGTC_2019 4016004 108 µM 0.618027038576152 0.27772385023289 no 919 0.268278757691104 1275 45595336 SGTC_3112 9123419 49.47 µM 0.61723650460603 0.277987670309013 no 920 0.268539370437894 1347 17015854 SGTC_1007 4101-0031 70 µM 0.614345457125049 0.278953522020521 no 921 0.26949353499676 1309 1146276 SGTC_656 4090-1979 187 µM 0.613222427556518 0.279329147571818 no 922 0.269864638628502 1338 22330961 SGTC_474 dl-dihydrosphingosine 5 µM 0.611988937998738 0.279742002237585 no 923 0.270272538216521 1361 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1782 st039423 80.636 µM 0.611375227334494 0.279947524282108 no 924 0.270475599446294 1286 2068169 SGTC_2598 perillyl alcohol 100 µM 0.610627379886235 0.280198065549282 no 925 0.270723146125402 1368 10819 An apoptosis inducer. SGTC_1667 st014849 34.6 µM 0.610564063558732 0.280219282553542 no 926 0.270744109799464 1341 5348460 SGTC_2261 9010538 184.68 µM 0.60969046942969 0.28051209927155 no 927 0.271033434529521 1264 6457250 SGTC_2886 9058944 51.95 µM 0.607785553017561 0.281151114071477 no 928 0.271664856136903 1228 4949929 SGTC_1709 st033179 39.1045 µM 0.60455841381781 0.282235277619301 no 929 0.272736222708893 1314 573381 SGTC_1738 st035555 74 µM 0.604244775902628 0.282340752052892 no 930 0.272840457921428 1340 5331140 SGTC_313 3474-0040 5.03 µM 0.603933707328672 0.28244538116073 no 931 0.272943858746475 1291 1043375 YIL048W NEO1 SGTC_1151 3909-8316 15.3 µM 0.602678014323062 0.282867927778045 no 932 0.273361455114396 1334 800431 SGTC_2826 7992541 19.48 µM 0.601431153741914 0.283287802406608 no 933 0.273776426970137 1390 2985066 SGTC_1382 3002-2117 298 µM 0.600981393814739 0.283439330336563 no 934 0.273926189501418 1389 1497314 SGTC_1223 0764-0573 147 µM 0.598115638193255 0.284405739020807 no 935 0.274881388192845 1337 1609797 SGTC_591 4299-0174 154 µM 0.598015149927257 0.284439654876739 no 936 0.274914912183557 1341 5509088 SGTC_782 0083-0095 30.5 µM 0.59770204182019 0.284545344573421 no 937 0.275019381409008 1344 3591729 An indicator and reagent. SGTC_321 4534-3890 65.3 µM 0.59763196799883 0.284569000572353 no 938 0.275042764375264 1364 699746 SGTC_231 b-estradiol 524 µM 0.59747010942051 0.284623645485854 no 939 0.27509677878321 1286 450 A steroid. SGTC_2961 9083290 32.55 µM 0.596725258728998 0.284875178343348 no 940 0.275345412902146 1366 17741490 SGTC_487 nimodipine 119 µM 0.595507861107505 0.285286516409735 no 941 0.275752022990662 1260 4497 L-type voltage-gated calcium channels inhibitor SGTC_2776 terbinafine 19.92 µM 0.595328817595346 0.285347036043482 no 942 0.275811848301377 1339 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3069 9117009 49.47 µM 0.594656765472229 0.285574255184401 no 943 0.276036463597837 1254 41904981 SGTC_691 1548-0686 185 µM 0.593567631679167 0.285942671349034 no 944 0.276400667818685 1296 46495133 SGTC_900 1112-0045 141 µM 0.593029288515419 0.286124857557125 no 945 0.276580775722199 1275 56211 YIL048W NEO1 SGTC_3049 9092223 49.47 µM 0.592640443959049 0.286256484705552 no 946 0.276710903196185 1335 8623917 SGTC_3354 9151612 71.43 µM 0.592547206841245 0.286288050526409 no 947 0.276742109610094 1375 27261949 SGTC_2592 piperlongumine 83.33 µM 0.59208641518142 0.286444077755343 no 948 0.276896361647109 1302 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_196 k015-0023 18.111 µM 0.591544664232577 0.286627569951708 no 949 0.277077768993324 1343 5211998 SGTC_2079 5212404 121 µM 0.58998704321831 0.287155449813509 no 950 0.277599668054311 1394 758462 SGTC_610 4215-0184 155 µM 0.588773890541727 0.287566907451694 no 951 0.278006481423273 1390 5605015 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.5881448110774 0.287780378199648 no 952 0.278217548680084 1357 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1442 4112-3290 3 µM 0.587357354083584 0.288047697962503 no 953 0.278481864464265 1328 704353 SGTC_2270 7924575 90.91 µM 0.586782269534039 0.288242997202169 no 954 0.278674973126739 1404 1262135 SGTC_2917 7979103 53.79 µM 0.586375541041094 0.288381160265636 no 955 0.278811588560462 1418 2980565 SGTC_2680 butyl paraben 22.24 µM 0.585856551508635 0.288557503008075 no 956 0.278985958505629 1386 7184 An antifungal and steroid mimetic. SGTC_1879 gemcitabine 100 µM 0.583386798951119 0.289397373186095 no 957 0.279816471265811 1362 60750 A nucleoside analog which inhibits DNA replication. SGTC_1975 st070967 30.8 µM 0.583223985091181 0.289452780396875 no 958 0.279871263389789 1367 261391 SGTC_508 roscovitine 141 µM 0.583161678890095 0.289473985148339 no 959 0.279892232816033 1423 160355 A CDKinase inhibitor. SGTC_1626 st003712 1.76 µM 0.583129223983614 0.289485030858399 no 960 0.279903155959488 1355 24207035 SGTC_783 0848-0141 92.7 µM 0.583047412479797 0.289512875482112 no 961 0.279930691659371 1357 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3006 9075424 71.4286 µM 0.581956079649303 0.289884431895322 no 962 0.280298132489938 1322 7465181 SGTC_744 1594-0068 283 µM 0.581521052016709 0.29003260421541 no 963 0.280444667024924 1380 668392 SGTC_682 0kpi-0099 17 µM 0.578913967359065 0.290921331755979 no 964 0.281323612606474 1358 1714895 YML126C ERG13 SGTC_2309 7664088 163.95 µM 0.578863131119495 0.290938673934584 no 965 0.281340764609616 1387 704922 SGTC_2096 5468907 200 µM 0.578580858173555 0.291034976780779 no 966 0.28143601188296 1393 759785 SGTC_535 2293-4129 48.2 µM 0.578330564776343 0.29112038164297 no 967 0.281520481320125 1410 396118 YIL048W NEO1 SGTC_468 gf-109203x 121 µM 0.576223285003921 0.291839889197008 no 968 0.282232134159081 1322 2396 A protein kinase C inhibitor. SGTC_1872 amphotericin b 148 nM 0.576220460633604 0.291840854102917 no 969 0.282233088562417 1368 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1038 k292-0204 154 µM 0.576213286879684 0.291843304920493 no 970 0.282235512704304 1305 4454212 SGTC_3303 9125618 40.5795 µM 0.571865512044877 0.293330424853327 no 971 0.283706545159355 1460 22695467 SGTC_1349 flufenamic acid 69 µM 0.571133296889847 0.293581218010175 no 972 0.283954644706526 1351 3371 A non-steroidal anti-inflammatory. SGTC_2754 granisetron 64.02 µM 0.569822304212661 0.294030497788155 no 973 0.284399113059765 1443 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_163 TUB2.036 7.546 µM 0.569630052808744 0.294096409437404 no 974 0.284464320359215 1395 15992207 YJR013W GPI14 SGTC_997 3996-0078 137 µM 0.569598433275313 0.294107250561392 no 975 0.284475045669013 1394 735687 SGTC_416 estradiol valerate 100 µM 0.56950497904763 0.294139293507481 no 976 0.284506746365965 1385 13791 A steroid. SGTC_1162 k048-0130 20.1 µM 0.567378788821111 0.294868742522929 no 977 0.285228428859661 1356 6797406 SGTC_813 k007-0158 173 µM 0.566847116940989 0.295051277661873 no 978 0.28540902792046 1440 6523916 SGTC_574 1315-0397 40 µM 0.566358516561367 0.295219071247083 no 979 0.285575044393705 1371 6794277 SGTC_2847 9005661 71.43 µM 0.56398617329451 0.29603439752943 no 980 0.28638177104056 1314 2991449 SGTC_1222 0366-0074 1.18 µM 0.561526788921195 0.296880727540691 no 981 0.287219236657895 1442 286520 SGTC_101 0490-5701 117.494 µM 0.561407283604928 0.296921880227559 no 982 0.287259959929297 1348 4661669 SGTC_1669 st015249 58.4 µM 0.559920374187289 0.297434128433424 no 983 0.287766875502549 1447 722793 SGTC_2930 9013230 14.89 µM 0.556203397099172 0.298716408920879 no 984 0.289035908591893 1451 2995857 SGTC_2967 9089538 49.85 µM 0.555785638990583 0.298860683817932 no 985 0.289178702028564 1476 728216 SGTC_2558 carylophyllene oxide 100 µM 0.554926423251899 0.299157517838976 no 986 0.289472493820656 1448 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2116 5511452 16.8835 µM 0.553775251062761 0.299555423905511 no 987 0.289866333924985 1423 870744 SGTC_1783 st039459 87.517 µM 0.553010861815209 0.299819769745412 no 988 0.29012798626032 1527 729761 SGTC_2092 5303694 80.6725 µM 0.552222859584729 0.300092392082943 no 989 0.290397837183966 1378 1963699 SGTC_1710 st031758 61.5 µM 0.551817023460119 0.30023284149758 no 990 0.290536861367222 1485 5394341 SGTC_3275 9138069 49.47 µM 0.551725006591494 0.30026469029464 no 991 0.290568387214406 1432 17617007 SGTC_2954 9074818 52.69 µM 0.551287315214519 0.300416204550901 no 992 0.290718366319005 1449 16648742 SGTC_3162 9099653 49.47 µM 0.548601459596688 0.301346714104408 no 993 0.291639491978032 1397 25237511 SGTC_2005 4024620 188 µM 0.548199098594045 0.301486222994425 no 994 0.291777600495028 1397 236743 SGTC_1886 st057356 49.9 µM 0.548052020915153 0.301537225854518 no 995 0.291828091819384 1346 24207747 SGTC_3034 9090421 49.47 µM 0.547796419345329 0.301625871319472 no 996 0.291915848751139 1385 17173761 SGTC_439 amiodarone 34.4 µM 0.547552221302935 0.301710572860933 no 997 0.291999701932591 1462 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1855 st056195 39.6 µM 0.546278548618677 0.302152527046411 no 998 0.292437239724536 1469 4028379 SGTC_3217 9129673 49.47 µM 0.544310221900109 0.30283609152785 no 999 0.293114006996052 1410 17248312 SGTC_1946 st076057 65.1 µM 0.543562424747953 0.303095969415278 no 1000 0.293371311401947 1335 953009 SGTC_1201 1889-3372 45.9 µM 0.541697517356346 0.303744504741035 no 1001 0.294013450148637 1399 5392199 SGTC_715 0868-0130 184 µM 0.541560882931226 0.303792044709652 no 1002 0.294060522664363 1560 2876258 SGTC_1721 st082152 9.2685 µM 0.540134485310674 0.304288537182036 no 1003 0.294552144943598 1364 5296051 SGTC_3139 9095020 49.47 µM 0.539781823986916 0.304411345247511 no 1004 0.294673751663742 1274 25236292 SGTC_605 1315-0399 119 µM 0.538774294896602 0.304762320911064 no 1005 0.295021301195147 1476 24020461 SGTC_2770 toltrazuril 17.5 µM 0.538581932411331 0.304829351383529 no 1006 0.295087678549331 1413 68591 Kills coccidiodes. SGTC_161 4065-0411 162.148 µM 0.538185765071805 0.304967420164643 no 1007 0.29522440327112 1482 1906281 YLR208W SEC13 SGTC_2916 7875993 68.79 µM 0.536752619647232 0.305467119321976 no 1008 0.295719251815527 1525 1299250 SGTC_2630 antimycin a 100 µM 0.536518032826294 0.30554894798094 no 1009 0.295800288219574 1372 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3282 9108498 15.4605 µM 0.534809822053292 0.306145099373844 no 1010 0.296390685241229 1407 16459645 SGTC_2544 sphondin 68.51 µM 0.534184561464756 0.306363438654784 no 1011 0.296606924686291 1475 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_115 0527-0192 112.043 µM 0.534068351775511 0.306404026340282 no 1012 0.296647122481786 1446 4233931 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.532842937480909 0.306832162096395 no 1013 0.297071154185403 1392 6708760 SGTC_2099 5377090 177.372 µM 0.531644710068078 0.307251054232659 no 1014 0.297486046194646 1410 2243829 SGTC_2201 6605497 169.863 µM 0.53159327570868 0.307269040969933 no 1015 0.297503861510167 1474 670741 SGTC_1163 k060-0048 49.9 µM 0.530521403328122 0.307643983148736 no 1016 0.297875236672187 1425 6809982 SGTC_2564 betulinic acid 100 µM 0.529129371916035 0.308131217340617 no 1017 0.298357853655971 1619 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_308 4092-1169 104 µM 0.528610973323566 0.308312751989915 no 1018 0.298537673243881 1461 2268590 YDL196W YDL196W SGTC_1345 1488-0192 31.4 µM 0.527543515625515 0.308686705737084 no 1019 0.298908102972978 1468 658348 SGTC_2616 abietic acid 100 µM 0.524841852974205 0.309634043387718 no 1020 0.299846567009965 1477 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2774 tamoxifen 10.92 µM 0.524023913814645 0.309921103613991 no 1021 0.300130953581152 1464 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_32 0928-0142 34.1 µM 0.522467165811484 0.310467773023077 no 1022 0.30067255089236 1427 2244242 SGTC_1904 st060225 78 µM 0.521852951636948 0.310683576487872 no 1023 0.300886359140729 1401 66595 SGTC_1414 3917-0015 5.4 µM 0.520850434883387 0.311035949568654 no 1024 0.301235482914893 1440 6618702 SGTC_2913 7966556 36.57 µM 0.51821685445427 0.311962447716856 no 1025 0.302153488276436 1503 2976516 SGTC_528 3492-0019 172 µM 0.518113234305891 0.311998925852815 no 1026 0.302189633534033 1478 2869262 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.517389624493493 0.31225371472882 no 1027 0.302442100520489 1477 368090 SGTC_206 4546-0025 72.014 µM 0.515784844888184 0.312819090951662 no 1028 0.30300234424488 1452 6620745 YIL048W NEO1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.514754293382173 0.313182394608531 no 1029 0.303362364196294 1444 688664 SGTC_2800 7887935 81.82 µM 0.514647910949916 0.313219908287633 no 1030 0.303399539449632 1498 2961002 SGTC_3095 9117207 49.47 µM 0.513428900208836 0.313649906428388 no 1031 0.303825666959689 1457 17015229 SGTC_3194 9111903 49.47 µM 0.513265623582381 0.313707520449236 no 1032 0.303882763562389 1512 17087251 SGTC_973 1325-0077 65.9 µM 0.510487477149542 0.314688516542293 no 1033 0.304854992842558 1571 2835149 SGTC_1103 duloxetine 36.1 µM 0.510133859066657 0.31481347731765 no 1034 0.304978842754235 1578 60835 A selective serotonin reuptake inhibitor. SGTC_2868 9035608 32.47 µM 0.508732023807848 0.315309063319335 no 1035 0.305470036184329 1435 6462614 SGTC_2109 5483026 200 µM 0.508610803821212 0.315351933436322 no 1036 0.305512527305012 1502 759335 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.507662547175535 0.315687375382071 no 1037 0.305845009126842 1537 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2412 st077135 33.4 µM 0.506456294189979 0.316114301974134 no 1038 0.30626818206021 1545 13258915 SGTC_283 0987-0079 11.7 µM 0.504844015804447 0.316685315296394 no 1039 0.306834198968154 1512 411556 SGTC_1411 3909-8223 150 µM 0.502699701648487 0.31744543444924 no 1040 0.307587709745063 1550 X1411 SGTC_2043 5101342 149 µM 0.502211427776786 0.317618626186254 no 1041 0.30775940259479 1461 678451 SGTC_2399 5884133 200 µM 0.501549648255275 0.317853424448007 no 1042 0.307992172833551 1459 722445 SGTC_1447 4239-0816 81.9 µM 0.501271286003502 0.317952208799385 no 1043 0.308090105343308 1430 1341554 SGTC_126 0417-1624 672.48 µM 0.50103535670627 0.318035944816453 no 1044 0.308173119927992 1533 41912 YDL195W SEC31 SGTC_2003 4023581 200 µM 0.500538724655641 0.318212239843181 no 1045 0.308347898005416 1494 16641307 SGTC_3219 9131112 49.47 µM 0.500380679036579 0.318268351703227 no 1046 0.30840352759403 1449 17612988 YMR079W SEC14 SGTC_1122 capsaicin 818.572 nM 0.500131068376545 0.31835698092892 no 1047 0.308491395607295 1571 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1166 k206-0078 225 µM 0.49953288225244 0.318569421110386 no 1048 0.308702013889007 1453 5404595 SGTC_1075 aripiprazole 15.2 µM 0.499185062415098 0.318692973490628 no 1049 0.308824508422975 1471 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3250 9135583 49.47 µM 0.499118608122948 0.31871658164346 no 1050 0.308847914590675 1552 7699353 SGTC_904 1141-0088 396 µM 0.497336731130678 0.319349874672782 no 1051 0.309475806818307 1404 1378119 SGTC_98 0074-0023 107.663 µM 0.496630693287401 0.319600952036404 no 1052 0.309724752290296 1435 3563821 SGTC_3339 9145883 14.936 µM 0.494928044371039 0.320206778906339 no 1053 0.310325456883258 1515 2030670 SGTC_524 r073-0010 27.8 µM 0.494435828454738 0.320382005815836 no 1054 0.310499207984856 1430 2772106 SGTC_330 1488-0319 80.1 µM 0.494159590788521 0.320480362876118 no 1055 0.310596737783281 1506 6846614 SGTC_1297 1068-0111 14.1 µM 0.492614243498881 0.321030830963284 no 1056 0.311142590949653 1429 767057 SGTC_1606 st000094 49.2 µM 0.491649795028851 0.32137457665326 no 1057 0.311483467667112 1545 1242210 SGTC_713 1488-1073 324 µM 0.491480787998984 0.321434829375377 no 1058 0.311543218525611 1496 3312542 SGTC_1115 galangin 695.678 nM 0.491382561466757 0.321469850290626 no 1059 0.31157794788029 1528 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.491253982076566 0.321515695373412 no 1060 0.311623411442758 1525 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3343 9148379 18.9835 µM 0.489205282486239 0.322246527187713 no 1061 0.312348185029858 1634 1955036 SGTC_2145 5634607 200 µM 0.488392765129859 0.322536566811305 no 1062 0.312635832733093 1451 308662 SGTC_1691 st019933 84.6 µM 0.488064439673283 0.322653797908734 no 1063 0.312752099032125 1527 6176082 SGTC_1780 st038448 24.544 µM 0.48758112972226 0.322826399473432 no 1064 0.31292328219191 1594 728868 YDL195W SEC31 SGTC_3323 9138564 53.9225 µM 0.486796920481599 0.323106540591894 no 1065 0.313201126453749 1616 43912313 YNL103W MET4 SGTC_2122 5258151 111.688 µM 0.485089121556656 0.323716960460797 no 1066 0.313806564177106 1458 2173356 SGTC_2196 6573537 42.6665 µM 0.483640582135244 0.324235085062172 no 1067 0.314320484262356 1588 2903087 SGTC_2445 5742597 35.57 µM 0.480379618363178 0.325402736508757 no 1068 0.315478742138788 1460 1774255 SGTC_2600 tangeritin 87.95 µM 0.478852491993081 0.32595014446559 no 1069 0.316021785227954 1438 68077 A bioactive flavone. SGTC_1021 4476-0760 85.3 µM 0.477970633214467 0.326266423283101 no 1070 0.316335553447312 1475 746768 SGTC_3224 9130643 49.47 µM 0.477704152359979 0.326362021292039 no 1071 0.316430394236081 1571 17644395 SGTC_1501 4491-0275 38.4 µM 0.474743124499874 0.327425034249898 no 1072 0.31748503812671 1541 5104718 SGTC_2064 5220758 200 µM 0.474544576182947 0.327496363568272 no 1073 0.317555809214582 1554 788518 SGTC_992 3909-8734 162 µM 0.474068241996856 0.327667514302051 no 1074 0.317725622218407 1502 4288319 SGTC_1479 0549-0158 134 µM 0.473696827846971 0.327800991546351 no 1075 0.317858057870232 1522 5440202 SGTC_619 1652-1634 108 µM 0.473467497774801 0.327883418204991 no 1076 0.317939842044935 1515 5400454 SGTC_1400 3771-8998 51.5 µM 0.472461870859752 0.328244963292273 no 1077 0.318298575647847 1559 670767 SGTC_669 0108-0021 26.2 µM 0.471511838281675 0.328586668842441 no 1078 0.318637633896936 1791 17201 SGTC_1245 0418-0076 17.2 µM 0.471387596899606 0.328631366307554 no 1079 0.318681985788167 1555 6790114 SGTC_2560 caryophyllene 100 µM 0.471179126813144 0.328706371661295 no 1080 0.318756411615453 1531 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3260 9137109 49.47 µM 0.470913956838751 0.328801787012041 no 1081 0.31885109041215 1581 17478346 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.470878830277604 0.328814427338906 no 1082 0.318863633218877 1495 688803 SGTC_336 4111-0029 111 µM 0.470554435666096 0.328931170305175 no 1083 0.31897947613483 1492 3131175 SGTC_130 0136-0219 337.655 µM 0.470202776377249 0.329057744123139 no 1084 0.319105075377425 1552 234244 SGTC_1797 st048695 56.8 µM 0.469895165930365 0.329168479377903 no 1085 0.319214959089726 1601 592262 YIL048W NEO1 SGTC_2996 9066192 71.4286 µM 0.468507711388104 0.329668128855479 no 1086 0.319710778858842 1445 6472854 SGTC_1273 0849-0096 14.1 µM 0.468127339424612 0.329805161390042 no 1087 0.319846764654289 1508 5286025 SGTC_2845 9003024 42.97 µM 0.466741797649899 0.330304508757996 no 1088 0.320342310751705 1612 2990173 SGTC_2870 9038528 12.99 µM 0.466626659429456 0.330346018034366 no 1089 0.320383504961409 1505 6463316 SGTC_1850 st056238 17 µM 0.466558234677059 0.330370687304236 no 1090 0.320407987051833 1507 5393177 SGTC_795 0685-0265 78 µM 0.4660840465187 0.33054166726398 no 1091 0.320577671064408 1521 302754 SGTC_708 3448-5400 146 µM 0.465254181415991 0.330840980219909 no 1092 0.320874721144134 1509 3462195 SGTC_1919 st067113 52.3 µM 0.465090667057671 0.330899968792037 no 1093 0.320933264615511 1514 1268243 SGTC_1984 st072354 53.1 µM 0.463499258662657 0.331474295933583 no 1094 0.321503273053335 1546 5762938 SGTC_1615 st002656 86.5 µM 0.460391137748098 0.332597135511277 no 1095 0.32261774734134 1519 1584458 SGTC_3289 9119912 71.43 µM 0.460012571096784 0.332733999392833 no 1096 0.322753598618809 1547 17014829 SGTC_1260 0700-1617 7.75 µM 0.45952043324094 0.332911956203884 no 1097 0.322930241082873 1562 2853078 SGTC_2071 5230951 39.92 µM 0.457428146940808 0.333668945708606 no 1098 0.323681668526625 1537 1799272 SGTC_863 0466-0191 129 µM 0.456741590724307 0.333917489660258 no 1099 0.323928396466856 1596 765160 YPR165W RHO1 SGTC_537 1334-0398 209 µM 0.45672199492688 0.333924584711678 no 1100 0.323935439751483 1646 5846986 SGTC_3171 9103192 49.47 µM 0.455910747956022 0.33421836502282 no 1101 0.324227080188598 1596 13018434 SGTC_2725 haloperidol 53.21 µM 0.455716179176521 0.334288840152055 no 1102 0.324297043027721 1511 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2843 9000894 45.46 µM 0.454619750512936 0.334686088821927 no 1103 0.324691411624357 1473 2242070 SGTC_1481 3346-2004 36 µM 0.453785025619558 0.334988643350733 no 1104 0.32499178123165 1539 2770522 SGTC_89 0302-0250 142.109 µM 0.452856114110602 0.335325462704963 no 1105 0.325326176973989 1613 4203518 YLR208W SEC13 SGTC_1470 k295-0292 231 µM 0.452682131709275 0.335388562713559 no 1106 0.3253888239667 1610 5045612 SGTC_2750 bromebric acid 70.15 µM 0.452463780624178 0.335467760945817 no 1107 0.325467454066429 1594 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2899 9053889 58.44 µM 0.450841884901759 0.336056268214483 no 1108 0.326051755604553 1582 6470052 SGTC_105 0111-0055 734.78 µM 0.450753781043135 0.336088248357666 no 1109 0.326083508009017 1542 5179370 SGTC_2249 haloperidol 116.36 µM 0.450535619686709 0.336167442179357 no 1110 0.326162138228578 1599 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_178 4092-0806 87.505 µM 0.450503206911292 0.336179208822972 no 1111 0.326173821175423 1521 2169044 SGTC_1035 k081-0041 55.2 µM 0.450322789217898 0.336244707865761 no 1112 0.326238854525264 1586 731709 SGTC_2418 pentamidine 31.67 µM 0.45023777841335 0.336275572007232 no 1113 0.326269499345788 1480 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1202 1988-0068 29.6 µM 0.450162001896588 0.336303084465517 no 1114 0.326296816365359 1496 2850480 SGTC_1026 k007-1105 30.6 µM 0.449643401491296 0.336491398143667 no 1115 0.326483793978148 1539 7066794 SGTC_1415 3966-0071 78.1 µM 0.449005903008885 0.336722942178014 no 1116 0.32671369917313 1560 2893185 SGTC_166 k072-0058 166.424 µM 0.448684608287389 0.336839662200472 no 1117 0.326829594713228 1586 5846229 SGTC_2124 5246320 200 µM 0.448064996988996 0.337064799108519 no 1118 0.327053144425491 1585 579342 SGTC_2323 6148992 148.28 µM 0.448044134556134 0.337072380528246 no 1119 0.327060672468313 1505 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3178 9107506 49.47 µM 0.446863945981743 0.337501369395473 no 1120 0.327486648625135 1572 8897194 SGTC_141 0443-0274 32.331 µM 0.446829153875451 0.33751401924946 no 1121 0.327499209867587 1612 1627241 SGTC_780 0109-0199 192 µM 0.446148520739636 0.337761523499896 no 1122 0.327744982968794 1682 610414 SGTC_2894 9048625 32.47 µM 0.446028402582463 0.33780521034585 no 1123 0.32778836476496 1685 4092861 SGTC_957 1187-1561 14.1 µM 0.445760110036651 0.337902795949751 no 1124 0.327885269520503 1541 1538454 SGTC_969 1313-0238 134 µM 0.444800587011343 0.338251890799323 no 1125 0.32823193506069 1568 5212874 SGTC_1506 4226-2149 212 µM 0.443634679166042 0.338676260003866 no 1126 0.328653364389495 1605 991114 SGTC_613 3914-0030 117 µM 0.44345767158983 0.338740705462806 no 1127 0.328717364665506 1517 1145395 SGTC_2676 harmalol 100 µM 0.442041527315858 0.33925646944075 no 1128 0.329229577869886 1624 5459187 A monoamine oxidase inhibitor SGTC_2959 9079155 11 µM 0.441384676629408 0.339495798779178 no 1129 0.329467266834376 1566 16189457 SGTC_182 3448-4371 550.524 µM 0.439428670464067 0.340208870018996 no 1130 0.3301754780114 1702 3491403 SGTC_194 1486-1323 56.904 µM 0.4386589553842 0.340489630201698 no 1131 0.3304543358554 1534 5178754 SGTC_1518 st038567 90.8 µM 0.437787999396063 0.340807425503834 no 1132 0.330769985531444 1546 77966 SGTC_899 1083-0020 478 µM 0.437785007570308 0.340808517359137 no 1133 0.330771070028977 1663 767123 SGTC_1503 4585-0012 61.3 µM 0.436969241162541 0.341106277901093 no 1134 0.331066827605019 1636 2922052 SGTC_1431 4049-0260 9.09 µM 0.435382222241263 0.341685834548091 no 1135 0.331642506131119 1590 3854841 SGTC_1004 4084-0029 199 µM 0.433744241307868 0.342284393384967 no 1136 0.332237087989268 1688 716894 YLR208W SEC13 SGTC_2476 5806916 10.51 µM 0.433367193808272 0.342422232071392 no 1137 0.332374014909564 1615 2870194 SGTC_2717 st081029 62.2815 µM 0.432294674224583 0.342814431854565 no 1138 0.332763628724184 1631 5292846 SGTC_157 1348-1695 65.819 µM 0.429521256970457 0.343829402035243 no 1139 0.333771963863643 1560 5380510 SGTC_1564 D-Arginine 115 µM 0.429114407227138 0.343978389219738 no 1140 0.333919984026046 1486 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_198 3454-2873 16.191 µM 0.429096071901967 0.343985104132803 no 1141 0.333926655396804 1599 710957 SGTC_1573 oleylamine 1.06 µM 0.428028807207646 0.344376051283915 no 1142 0.334315073692147 1555 5356789 An amine of the fatty acid oleic acid. SGTC_2543 pimpinellin 60.67 µM 0.427627409641413 0.344523129321875 no 1143 0.334461203509893 1533 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2606 farnesol 9.78 µM 0.424710299706217 0.345592706805694 no 1144 0.335523937271153 1674 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2276 7947513 42.08 µM 0.423592994916629 0.346002701204631 no 1145 0.335931332478806 1444 2105100 SGTC_2110 5483698 200 µM 0.423220853908039 0.346139298268377 no 1146 0.336067066546658 1607 2848765 YHR062C RPP1 SGTC_86 0417-1630 471.922 µM 0.422328871567304 0.346466788349165 no 1147 0.336392493649541 1606 3634867 SGTC_980 1473-0395 201 µM 0.421316047424559 0.346838784506357 no 1148 0.336762156814756 1555 768876 SGTC_2472 5377652 49.4 µM 0.419920258412033 0.3473516802724 no 1149 0.337271853961511 1567 1610903 SGTC_433 pimozide 108 µM 0.419892793976358 0.347361775145332 no 1150 0.337281886088487 1501 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_541 4513-1321 94 µM 0.419488841574664 0.347510265055855 no 1151 0.337429453975873 1553 747515 SGTC_3252 9135871 49.47 µM 0.419165809529906 0.347629026083941 no 1152 0.337547478836826 1632 17682838 SGTC_424 splitomicin 100 mM 0.415050776946685 0.349143201273232 no 1153 0.339052366077266 1558 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2156 5649887 115 µM 0.413095727099471 0.349863429312947 no 1154 0.339768239935087 1706 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2138 5575593 77.673 µM 0.411508705330582 0.350448475784114 no 1155 0.340349779644998 1570 762213 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.411162347962244 0.350576205676735 no 1156 0.340476747520213 1678 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1459 k035-0031 35.7 µM 0.410644841260801 0.350767083608228 no 1157 0.340666489101936 1507 3877128 YMR208W ERG12 SGTC_1996 st072960 66.8 µM 0.410073269471055 0.350977946770225 no 1158 0.340876100277596 1702 1719405 SGTC_858 0438-0351 2.77 µM 0.409017691808553 0.351367489063594 no 1159 0.341263338908861 1573 2799119 SGTC_936 3005-4620 401 µM 0.40834129054656 0.351617185133151 no 1160 0.341511564623133 1718 777207 SGTC_3138 9097216 49.47 µM 0.4074275086299 0.351954612833509 no 1161 0.341847013154481 1608 25237486 SGTC_385 1494-0393 12.4 µM 0.407404281451173 0.351963191339156 no 1162 0.341855541460074 1643 3090647 SGTC_540 1187-0821 17.3 µM 0.406941519657898 0.352134119086255 no 1163 0.342025470172461 1578 847520 SGTC_2381 9035592 200 µM 0.406858307244118 0.352164857962537 no 1164 0.342056029630737 1532 4749657 SGTC_1119 parthenolide 318.541 nM 0.405984826494818 0.352487582213492 no 1165 0.342376874677429 1703 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2814 7977482 42.97 µM 0.405356842859446 0.352719668485994 no 1166 0.342607614587976 1734 6456762 SGTC_3248 9135562 49.47 µM 0.404562393891647 0.353013354520779 no 1167 0.342899602980726 1629 17650701 SGTC_302 1094-0063 18.9 µM 0.40422648748614 0.353137556278751 no 1168 0.34302308883351 1605 5440289 SGTC_3183 9108214 49.47 µM 0.403027532368386 0.353580998745487 no 1169 0.343463985158176 1608 4974831 SGTC_2455 5377712 9.75 µM 0.402310199836165 0.353846404603024 no 1170 0.343727874500335 1549 2243908 SGTC_2955 9076254 12.21 µM 0.402065217290609 0.353937061973744 no 1171 0.343818015125581 1731 16459619 SGTC_2211 7117706 200 µM 0.400734184168919 0.354429763978561 no 1172 0.344307920004643 1696 822771 SGTC_2685 mycophenolic acid 18.85 µM 0.400513240936434 0.354511573058364 no 1173 0.344389266486643 1676 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1832 st054113 55 µM 0.398927114473177 0.355099068036251 no 1174 0.344973454811398 1686 1251267 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.396772755173784 0.35589758597359 no 1175 0.345767521674507 1674 6708739 YPR165W RHO1 SGTC_185 k048-0037 25.491 µM 0.395585897582054 0.356337767801801 no 1176 0.346205271162763 1738 6827589 SGTC_2850 9015429 58.44 µM 0.395148291242468 0.356500115619581 no 1177 0.346366725704635 1583 6457570 SGTC_2700 st077718 96.8 µM 0.393062836401054 0.357274156485722 no 1178 0.347136535892976 1608 904970 SGTC_1809 st050081 57.6 µM 0.391874884095161 0.357715341769221 no 1179 0.347575330687997 1703 5036894 SGTC_963 1269-2853 151 µM 0.390599371786696 0.358189257056711 no 1180 0.34804669503321 1578 3668223 SGTC_2241 6772625 37.8075 µM 0.389054690669667 0.358763474320384 no 1181 0.34861784487583 1587 2285411 SGTC_3249 9135183 49.47 µM 0.387155636946418 0.359469863074262 no 1182 0.349320495317955 1684 4902779 SGTC_737 1950-0117 57.9 µM 0.384969582844909 0.360283601869264 no 1183 0.350129975705932 1733 5393513 SGTC_3174 9107204 49.47 µM 0.384706525433455 0.360381565367306 no 1184 0.350227430011103 1700 3938802 SGTC_3176 9106582 49.47 µM 0.384471066943659 0.36046925870518 no 1185 0.350314668169155 1666 17018027 SGTC_92 0063-0024 660.874 µM 0.382849162230599 0.361073514419912 no 1186 0.350915803639845 1662 3594437 SGTC_1406 3909-7906 11.9 µM 0.382651172585759 0.361147301091917 no 1187 0.350989211230898 1683 X1406 SGTC_2462 5162487 171.77 µM 0.382119255865413 0.361345561102259 no 1188 0.351186454762656 1735 2259986 SGTC_42 0133-0086 60.653 µM 0.381843541673179 0.361448342033397 no 1189 0.351288709933412 1548 162923 Model of phenazepam hydroxylation. SGTC_3093 9117344 49.47 µM 0.381423377571152 0.361604990332071 no 1190 0.351444558493306 1666 24824913 SGTC_1332 1480-0653 17.5 µM 0.380879773556258 0.361807694716904 no 1191 0.3516462308255 1755 5749438 SGTC_798 1287-0182 476 µM 0.378629268361432 0.362647297142961 no 1192 0.352481592303645 1787 1649755 SGTC_3292 9120825 59.784 µM 0.377671657687135 0.363004756379552 no 1193 0.352837262486515 1808 24824900 SGTC_1165 k072-0275 30.3 µM 0.377252318979597 0.363161325754224 no 1194 0.352993051349602 1685 6153523 YGL055W OLE1 SGTC_13 0199-0087 65 µM 0.377223143515194 0.363172219909912 no 1195 0.353003891267367 1703 4589825 SGTC_1071 trifluoperazine 6.31 µM 0.377194280060457 0.363182997669719 no 1196 0.353014615377752 1747 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_662 k832-1615 104 µM 0.376473919899587 0.363452018864278 no 1197 0.353282300343777 1712 5878478 SGTC_1723 st034307 2.5525 µM 0.37555757392477 0.363794329017621 no 1198 0.353622918308411 1631 867466 SGTC_1990 st072050 59.8 µM 0.374442267688798 0.364211109457053 no 1199 0.354037650607326 1625 17233948 SGTC_3080 9117754 49.47 µM 0.372110379022383 0.365083034917796 no 1200 0.35490533450024 1789 9550191 SGTC_3025 9087895 49.47 µM 0.371767787800533 0.365211193434679 no 1201 0.35503287450588 1761 17173641 SGTC_728 3030-5151 22.5 µM 0.371706185643716 0.365234239525119 no 1202 0.355055809506525 1694 3125388 SGTC_1393 3470-5649 58.2 µM 0.371683468069051 0.36524273855948 no 1203 0.355064267583027 1652 4108395 SGTC_779 1360-0071 233 µM 0.369720078240976 0.36597752600643 no 1204 0.355795534979573 1835 7566 SGTC_74 000s-0487 160.283 µM 0.36787727642806 0.366667631630271 no 1205 0.356482372342621 1594 677548 SGTC_202 3594-0513 34.79 µM 0.366962678294518 0.36701029715987 no 1206 0.356823428615662 1695 708429 SGTC_2866 9034245 58.44 µM 0.365798874505736 0.367446483878526 no 1207 0.357257579888816 1795 6462273 SGTC_2506 ethyl hematommate 54.16 µM 0.36513813753285 0.367694200328681 no 1208 0.357504146867218 1599 3940691 An allergen. SGTC_1749 st037932 54.2 µM 0.365098082749127 0.367709219011241 no 1209 0.357519096010008 1656 594497 SGTC_1440 4100-1550 40 µM 0.363404897522468 0.368344269536749 no 1210 0.358151221903369 1685 742806 SGTC_3351 9150312 21.596 µM 0.362921038615717 0.368525813122185 no 1211 0.358331935083978 1688 4904905 SGTC_1001 4048-4355 44.4 µM 0.361007506449235 0.369244056504191 no 1212 0.359046917809242 1638 21824233 SGTC_1835 st008666 49.2 µM 0.358459416877134 0.37020118935866 no 1213 0.359999766690538 1640 690455 SGTC_1951 sophoraflavanone G 9.2 µM 0.357839307615518 0.370434241446261 no 1214 0.360231786246468 1649 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1826 st055655 41.6 µM 0.357132935859109 0.370699771013476 no 1215 0.360496144433096 1689 676168 SGTC_1134 3477-0009 42.5 µM 0.355206510849597 0.371424238974512 no 1216 0.361217443707395 1864 3973534 SGTC_1073 triclabendazole 3.09 µM 0.354668902451123 0.371626498061855 no 1217 0.361418825280024 1716 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2654 protoveratrine a 100 µM 0.354139587306141 0.371825671689833 no 1218 0.361617137818602 1724 5702278 A heart drug and vasodilator. SGTC_1519 esterone 74 µM 0.353847738668169 0.371935504785636 no 1219 0.361726497361404 1606 698 A steroid. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.35349180401195 0.372069469851364 no 1220 0.361859886068128 1654 4174840 SGTC_3042 9091578 49.47 µM 0.353396233277013 0.372105442967669 no 1221 0.361895704649181 1716 25236497 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.352730384408587 0.37235610147844 no 1222 0.362145289095744 1735 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3091 9116372 49.47 µM 0.352680388331381 0.372374924663735 no 1223 0.362164031816831 1713 17169793 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.349034077561135 0.373748555324113 no 1224 0.363531863113736 1695 689007 SGTC_3150 9097574 49.47 µM 0.346447159895264 0.374724068153094 no 1225 0.364503344208022 1831 17217476 SGTC_1674 st016616 23.6 µM 0.346034970599838 0.374879576788798 no 1226 0.364658216789162 1624 625830 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.345794804390472 0.374970194830966 no 1227 0.364748465032502 1728 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_893 0958-0369 48.9 µM 0.34397175753838 0.375658280426217 no 1228 0.365433762895976 1842 6819948 SGTC_81 0411-0046 9.971 µM 0.342947438405355 0.376045070269033 no 1229 0.365819001383609 1683 12925265 SGTC_2982 9019404 25.97 µM 0.341896994549981 0.376441854345738 no 1230 0.366214205749171 1515 22333232 SGTC_1456 k015-0012 13 µM 0.341293229111336 0.376669973750343 no 1231 0.366441422319974 1889 2989616 SGTC_2511 berberine 10.47 µM 0.338374791098631 0.377773246896235 no 1232 0.36754038434607 1708 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_745 0469-0705 296 µM 0.336828538393578 0.378358190280272 no 1233 0.368123079180745 1839 3486736 SGTC_892 0929-0076 29 µM 0.336697977579092 0.378407593883646 no 1234 0.368172294052526 1707 5751038 SGTC_859 0439-0102 54.6 µM 0.336013100049186 0.378666780890119 no 1235 0.368430493918423 1846 610143 SGTC_1880 MG-132 525 µM 0.333650718841853 0.37956122536139 no 1236 0.369321570551782 1807 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_473 2-arachidonoylglycerol 10 µM 0.333419590260433 0.379648769946164 no 1237 0.369408788732211 1687 5282280 An endocannabinoid. SGTC_1497 4476-2978 41.3 µM 0.333339631360983 0.379679057419256 no 1238 0.369438963414256 1746 1528379 SGTC_3149 9097855 49.47 µM 0.33329811411665 0.37969478394515 no 1239 0.369454631401447 1863 25236625 YMR079W SEC14 SGTC_3186 9110464 49.47 µM 0.332157042580441 0.38012709398574 no 1240 0.369885339520113 1788 17018021 SGTC_2256 7954252 200 µM 0.332019459805238 0.38017922917043 no 1241 0.369937282464883 1718 2972920 SGTC_1013 4112-3890 241 µM 0.329547847271495 0.38111618427019 no 1242 0.370870817405213 1701 705171 SGTC_395 anisomycin 6.25 µM 0.328837659872451 0.38138553599391 no 1243 0.371139198077347 1731 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1298 1079-1278 263 µM 0.328033034657745 0.381690774434561 no 1244 0.371443342648472 1746 2840950 SGTC_1304 1165-0502 251 µM 0.328021217481651 0.381695257885799 no 1245 0.371447810084477 1766 767425 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.326867241910405 0.382133154006574 no 1246 0.371884149245655 1720 390807 SGTC_549 1661-1316 519 µM 0.326621614988508 0.382226380904064 no 1247 0.371977046520481 1853 2857282 SGTC_700 3453-2283 142 µM 0.326382882347296 0.382316997643129 no 1248 0.372067343487789 1802 565664 SGTC_67 0335-0847 266 µM 0.325262706164547 0.382742273563082 no 1249 0.372491126869029 1939 4552207 YOR254C SEC63 SGTC_1632 st005650 90 µM 0.322353036717484 0.383847591834983 no 1250 0.373592629047377 1746 2759605 SGTC_2708 st078559 56 µM 0.321135125124327 0.384310530451498 no 1251 0.374053996427949 1756 17250902 SGTC_2376 9072922 81.32 µM 0.320530894601873 0.384540264947293 no 1252 0.374282957117589 1769 17087968 SGTC_405 ebelactone b 50 µM 0.319948118066719 0.38476188084492 no 1253 0.374503830276381 1740 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_758 0868-0029 16 µM 0.319443160623644 0.384953934468166 no 1254 0.374695243192856 1877 762687 SGTC_1153 4055-0057 267 µM 0.319441409756187 0.384954600435675 no 1255 0.374695906943414 1715 882706 SGTC_1776 st049249 45.9 µM 0.319432719743354 0.384957905811512 no 1256 0.374699201316421 1688 1822314 SGTC_891 0929-0073 133 µM 0.319248008629173 0.385028165412503 no 1257 0.374769227231647 1819 5603632 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.317491136736757 0.385696625012826 no 1258 0.37543548186622 1705 2333 A French combination drug. SGTC_2921 7974240 10.71 µM 0.315364055171743 0.386506397397009 no 1259 0.376242627606672 1787 2979074 YDR527W RBA50 SGTC_2134 5324836 1.464 µM 0.313466009012837 0.387229394445112 no 1260 0.37696332058855 1782 699272 SGTC_3246 9135460 32.98 µM 0.313287060628852 0.387297579059608 no 1261 0.377031289909845 1832 41446951 SGTC_672 1441-0018 53.7 µM 0.312844824811157 0.387466098865424 no 1262 0.377199279091295 1716 251141 SGTC_1019 4262-0212 3.4 µM 0.312153602482463 0.387729540738236 no 1263 0.37746189566947 1896 4677213 SGTC_1473 k844-0725 134 µM 0.311608132031806 0.387937469473824 no 1264 0.377669176647045 1802 54682906 SGTC_2670 beta-carotene 100 µM 0.311300064499668 0.388054916421961 no 1265 0.377786259128332 1820 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2988 9073640 71.4286 µM 0.310123302557835 0.388503636576565 no 1266 0.378233596192012 1791 9102229 SGTC_2951 9072950 58.06 µM 0.310014646071644 0.388545076732611 no 1267 0.37827490936819 1845 16488155 SGTC_849 0386-0493 241 µM 0.30979778010159 0.388627790356089 no 1268 0.378357369922364 1759 726119 SGTC_443 clozapine 122 µM 0.306050877967358 0.390057669419202 no 1269 0.379782954047524 1894 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1437 4092-1038 11.6 µM 0.305403188941177 0.390304989597692 no 1270 0.380029546658025 1769 3977136 SGTC_1734 st037168 69.4 µM 0.305074778468556 0.390430410169996 no 1271 0.380154599991116 1727 708907 SGTC_803 4488-1585 147 µM 0.303989870921335 0.390844819376986 no 1272 0.380567804027716 1857 747204 SGTC_417 st075190 100 µM 0.303849038436762 0.390898623181464 no 1273 0.38062145229007 1906 222757 SGTC_593 1203-0218 61.7 µM 0.303202655098739 0.391145594991544 no 1274 0.380867712862157 1874 3666956 SGTC_3128 9127691 49.47 µM 0.302296342166843 0.39149195528087 no 1275 0.381213083257942 1790 41316314 SGTC_373 0844-0104 25.9 µM 0.302236395604463 0.391514867743328 no 1276 0.381235930548295 1893 5375804 SGTC_370 0180-0345 38.7 µM 0.301932350385881 0.391631084115247 no 1277 0.381351816949899 1735 3989527 SGTC_2706 st078239 82.5 µM 0.301311563779715 0.391868399789335 no 1278 0.3815884619062 1776 15434492 SGTC_2928 9011484 9.79 µM 0.300756929279001 0.392080460728064 no 1279 0.381799927008913 1762 2994751 SGTC_2401 5128683 200 µM 0.300545725922462 0.39216122140663 no 1280 0.381880461640593 1681 708373 SGTC_1094 duloxetine 25.4 µM 0.299453009751453 0.392579132160325 no 1281 0.382297210334141 1801 60834 A selective serotonin reuptake inhibitor. SGTC_1981 st071826 47 µM 0.299125147847054 0.392704547566547 no 1282 0.382422279508978 1768 11838600 SGTC_8 0354-0001 70 µM 0.298461448380564 0.392958463360322 no 1283 0.382675497861229 1789 4993152 SGTC_681 1642-0006 26.6 µM 0.298445821759492 0.392964442287029 no 1284 0.382681460422425 1772 4446530 SGTC_3081 9117243 49.47 µM 0.29834410702539 0.393003360142646 no 1285 0.382720271816283 1904 45595589 SGTC_1527 coumarin 137 µM 0.297975731431062 0.393144316105887 no 1286 0.382860843118251 1850 323 A hepatotoxic, DNA x-linker. SGTC_1515 3460-0031 42.1 µM 0.297558038216437 0.393304160008896 no 1287 0.38302025258079 1845 2876596 SGTC_1854 st056233 32.9 µM 0.296161588589453 0.393838687354039 no 1288 0.383553340750526 1924 5393174 SGTC_3317 9138495 8.753 µM 0.295828509659172 0.393966211551107 no 1289 0.383680524694687 1796 17020139 SGTC_2219 9098279 200 µM 0.294611603658528 0.394432218579385 no 1290 0.384145298487876 1890 902349 SGTC_291 SEC14.278 35.5 µM 0.293839451551918 0.394727988123479 no 1291 0.384440293566468 1877 1068044 SGTC_3214 9129694 49.47 µM 0.292113149735066 0.395389459882095 no 1292 0.38510005645996 1903 17158655 SGTC_874 0599-0792 117 µM 0.291507580329449 0.395621569089021 no 1293 0.385331573618552 1948 765305 SGTC_3094 9117742 49.47 µM 0.291219234471824 0.395732102432624 no 1294 0.385441826406356 1728 17149698 SGTC_149 3970-0822 46.1 µM 0.290663456640389 0.395945175728359 no 1295 0.38565436140034 1769 3114250 YBL034C STU1 SGTC_477 mead ethanolamide 10 µM 0.289940203325982 0.396222502084288 no 1296 0.385930992098521 1803 16061185 SGTC_2051 5263410 176 µM 0.289374002381606 0.396439644484467 no 1297 0.386147593732118 1886 227584 SGTC_2713 st079149 53.4 µM 0.288689571485435 0.396702171860778 no 1298 0.386409471915422 1815 3103253 SGTC_3111 9122088 49.47 µM 0.28831564064788 0.396845620420162 no 1299 0.386552567873195 1896 16876704 SGTC_1056 3448-1962 115 µM 0.287696279469047 0.397083252464024 no 1300 0.386789619114489 1824 715507 SGTC_1654 st012436 41.8 µM 0.287185982571638 0.397279068225636 no 1301 0.386984959374885 1902 4323132 SGTC_3259 9138485 49.47 µM 0.286819117591695 0.397419860991185 no 1302 0.387125411980891 1902 17646153 SGTC_3308 9128332 17.569 µM 0.285348690304856 0.397984304818207 no 1303 0.387688506609294 1920 17332805 YDL196W YDL196W SGTC_1500 4488-1866 171 µM 0.284139808761148 0.398448510733211 no 1304 0.388151620326803 1898 2900003 SGTC_2011 4012611 177 µM 0.283942481308164 0.398524297387674 no 1305 0.388227230158677 1748 2049887 SGTC_2057 5236571 38.335 µM 0.283352716696245 0.398750828392945 no 1306 0.388453235123596 1918 54684039 YBR257W POP4 SGTC_2849 9019321 12.99 µM 0.282812698644048 0.398958281461539 no 1307 0.388660209730737 1808 16489627 SGTC_1221 2958-7315 257 µM 0.282405218095453 0.399114837887567 no 1308 0.388816407154924 1842 4562705 SGTC_1719 st032227 49.2 µM 0.281677795509753 0.39939435825804 no 1309 0.389095290987019 1727 3125804 SGTC_823 0417-1665 178 µM 0.281049603181582 0.399635789790442 no 1310 0.389336177292486 1835 3429856 SGTC_261 5-fluorouridine 15.376 µM 0.280840360314936 0.399716216085709 no 1311 0.389416422901359 1900 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_379 3970-0972 5.9 µM 0.279992693701709 0.400042075641039 no 1312 0.389741555189067 1825 2898042 YBL034C STU1 SGTC_93 0109-0045 59.227 µM 0.279510037132903 0.400227649344069 no 1313 0.389926718168599 1935 88733 SGTC_546 peri-Naphthalide 147 µM 0.278214523007369 0.400725865012396 no 1314 0.390423843524855 1886 223824 A penicillin ester. SGTC_3296 9122258 64.045 µM 0.277669462224569 0.4009355272785 no 1315 0.390633052345764 1822 4730474 SGTC_822 1487-0950 154 µM 0.276781669034523 0.401277085548725 no 1316 0.390973878743853 1942 1958375 SGTC_2581 avocatin a 64 µM 0.276305250654867 0.401460407829549 no 1317 0.391156811701216 1806 6710728 A skin care supplement. SGTC_2232 chlorophetanol 41.5365 µM 0.276259647941773 0.401477956555542 no 1318 0.391174323286589 1899 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2126 5251174 33.877 µM 0.276009061681573 0.401574390100452 no 1319 0.391270553135258 1973 790722 SGTC_3089 9117425 49.47 µM 0.275916380249225 0.401610058375561 no 1320 0.391306146239179 1757 9401657 SGTC_1671 st016596 74.5 µM 0.275694522486071 0.401695443247988 no 1321 0.391391351536874 1816 2829167 SGTC_1841 st054148 70 µM 0.275051032437949 0.401943125373219 no 1322 0.391638515745811 1781 675442 SGTC_2337 9009472 200 µM 0.274797312352985 0.402040794171932 no 1323 0.391735981535912 1916 5742383 SGTC_75 0159-0059 199.013 µM 0.273303670782711 0.40261589090674 no 1324 0.392309896918846 1918 5377270 SGTC_1475 4092-1048 11.7 µM 0.271692806837781 0.403236358009592 no 1325 0.392929116315691 1829 2881759 SGTC_2130 NSC 7 2.4545 µM 0.271641519786578 0.403256116592754 no 1326 0.392948835623548 1932 21448 SGTC_1929 genistein trimethyl ether 50.5 µM 0.270878175420318 0.403550227849976 no 1327 0.393242365595526 1995 136420 SGTC_1199 1638-0010 4.46 µM 0.26860176266905 0.404427637097981 no 1328 0.394118077857889 1786 3111136 SGTC_90 0870-0863 4.608 µM 0.267507480894876 0.404849583060586 no 1329 0.394539227533032 1788 1738164 SGTC_3127 9126946 49.47 µM 0.26687469662262 0.405093629947406 no 1330 0.394782819722963 1757 27243249 SGTC_668 1682-0499 62.6 µM 0.266492183572656 0.405241172252314 no 1331 0.394930089217241 1833 682214 SGTC_1994 st072947 40.9 µM 0.266097517257048 0.405393416411401 no 1332 0.395082053517168 1876 5286565 YDL195W SEC31 SGTC_425 3825-7017 13.1 µM 0.265657829143834 0.405563044771691 no 1333 0.395251372030048 1882 3397440 SGTC_1057 3448-5381 134 µM 0.264696288485631 0.405934061675957 no 1334 0.395621718452714 1930 5497911 SGTC_3077 9117319 49.47 µM 0.263242498584912 0.406495176615829 no 1335 0.396181838210871 1889 17154678 SGTC_3101 9120531 49.47 µM 0.263100509600086 0.406549989993042 no 1336 0.396236555587403 1939 24824904 SGTC_3001 9076041 71.4286 µM 0.263000115551266 0.406588747181073 no 1337 0.396275245026209 1831 16004211 SGTC_2900 5328528 85.29 µM 0.262458131272176 0.406797996360801 no 1338 0.396484130296426 1801 795359 SGTC_1989 st071868 50.2 µM 0.260611456422135 0.407511159670318 no 1339 0.397196076984793 1971 16414057 SGTC_1037 k284-1091 78.7 µM 0.259808563311134 0.407821322984247 no 1340 0.397505722582456 1804 3334711 SGTC_3209 9113616 49.47 µM 0.259360875668751 0.407994293005812 no 1341 0.397678406888707 2011 16649353 SGTC_1770 st043884 66.3 µM 0.259057951288887 0.408111342006992 no 1342 0.397795263764969 1845 670149 SGTC_2259 7964009 200 µM 0.258444897569783 0.408348249062802 no 1343 0.398031784970426 1899 313134 SGTC_1969 st069479 40.1 µM 0.258182795075217 0.408449545570852 no 1344 0.398132917726509 1937 3895485 SGTC_2791 5663188 71.43 µM 0.257903122860788 0.408557639112346 no 1345 0.398240837340391 1934 54690634 SGTC_2493 resveratrol 26.09 µM 0.256952243290193 0.408925206841179 no 1346 0.39860781990742 1819 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2627 acetyl isogambogic acid 100 µM 0.256775626877286 0.408993487718261 no 1347 0.398675993149785 1773 6857789 A caspase activator and apoptosis inducer. SGTC_3100 9120536 49.47 µM 0.256751914263272 0.409002655355655 no 1348 0.398685146361211 1979 16421196 SGTC_1138 3761-0006 1.03 µM 0.255445858687071 0.409507671954656 no 1349 0.399189377586907 1895 12061087 SGTC_952 1185-0122 232 µM 0.255340353866918 0.409548474401478 no 1350 0.399230117378185 1849 678600 SGTC_265 mycophenolic acid 32.932 µM 0.255153634002461 0.409620687980414 no 1351 0.399302220359568 1957 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1752 st044819 83.042 µM 0.255144572912398 0.409624192419077 no 1352 0.39930571944057 1802 441209 YML126C ERG13 SGTC_1321 1326-2144 215 µM 0.254402695979888 0.409911142878331 no 1353 0.399592234189125 1955 3513030 SGTC_2012 4023501 200 µM 0.253454954389723 0.410277789874385 no 1354 0.399958333042652 1808 3477460 SGTC_2434 5670830 169.91 µM 0.253003743822331 0.410452374530551 no 1355 0.400132660074364 1847 1549830 SGTC_974 1326-0144 138 µM 0.252987040383942 0.410458837849571 no 1356 0.400139113897713 1818 5411856 SGTC_2347 9049783 174.81 µM 0.252672126068069 0.410580697051817 no 1357 0.400260794628357 1930 6467988 YPL169C MEX67 SGTC_1299 1079-1439 3.74 µM 0.251240597449367 0.411134749821485 no 1358 0.400814049342194 1835 323161 SGTC_3066 9117245 49.47 µM 0.249900079303552 0.411653739069484 no 1359 0.40133231094711 1930 17176980 SGTC_1744 st037937 38.9 µM 0.249317980189843 0.411879150258999 no 1360 0.401557412095906 1914 1016152 SGTC_651 3253-0966 34.4 µM 0.247961623280495 0.412404496583736 no 1361 0.402082049917412 1863 781462 SGTC_1176 0848-0131 83.3 µM 0.247445273034198 0.41260453149209 no 1362 0.402281820228969 2005 6769040 SGTC_3300 9124615 50.48 µM 0.247324175841509 0.412651448025637 no 1363 0.402328675116856 1933 24824903 SGTC_2189 6047310 154.431 µM 0.247134650953042 0.412724877920249 no 1364 0.402402008843971 1863 711535 SGTC_3230 9131665 49.47 µM 0.244384151752716 0.413790879265442 no 1365 0.403466657401248 1901 15943720 SGTC_2825 7998094 58.44 µM 0.243944474644614 0.413961342509179 no 1366 0.403636911831306 1873 2987815 SGTC_741 4582-0002 126 µM 0.242212308619453 0.414633062419046 no 1367 0.404307829036334 1834 2912688 SGTC_347 4534-1311 26.2 µM 0.241382701767142 0.414954865775761 no 1368 0.404629259212837 1864 2862016 SGTC_2644 guaiazulene 100 µM 0.240518640225998 0.41529009473452 no 1369 0.404964107253519 1987 3515 A coloring agent. SGTC_2536 dehydroabietamide 32.04 µM 0.240283021510327 0.41538151816794 no 1370 0.405055428189569 1984 3983547 SGTC_1074 carmofur 3.8 µM 0.238156286236559 0.416206928610272 no 1371 0.405879940122863 1909 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_951 1171-0579 82.7 µM 0.237771377205968 0.416356355851801 no 1372 0.406029209875659 1869 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2587 piperic acid 92.2 µM 0.237579963178831 0.416430670042349 no 1373 0.406103446332872 1845 5370536 SGTC_1864 st057645 30.4 µM 0.235409028771479 0.41727371762346 no 1374 0.40694563950997 2021 688666 SGTC_1800 st050079 29.0735 µM 0.235342893566956 0.417299406161413 no 1375 0.406971302804563 1900 3645560 SGTC_941 3237-0776 460 µM 0.235249408898953 0.417335718504927 no 1376 0.407007579544809 1974 760008 SGTC_636 0kpi-0074 126 µM 0.234925903573983 0.417461383442867 no 1377 0.407133121992992 1881 616434 SGTC_2451 5856223 45.7 µM 0.232596022213394 0.418366669015672 no 1378 0.408037558211089 1846 2179896 SGTC_483 fpl-64176 144 µM 0.23228516080109 0.418487488388242 no 1379 0.40815826861755 1934 3423 SGTC_2898 9056270 58.44 µM 0.232165431371219 0.418534024471272 no 1380 0.408204763005594 1918 19154699 SGTC_1249 0481-0015 10.2 µM 0.230991593742362 0.418990328521217 no 1381 0.408660666336599 1859 4227577 SGTC_2212 7123476 200 µM 0.230927676960771 0.419015177925479 no 1382 0.408685494341344 1969 1085715 SGTC_46 0329-0187a 2.197 µM 0.230678146718926 0.419112192751936 no 1383 0.408782426039711 1937 46494817 SGTC_2565 isoliquiritigenin 100 µM 0.228567553858356 0.419932966009312 no 1384 0.409602522631235 1749 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_263 alizarin 107.927 µM 0.227187455532929 0.420469851115728 no 1385 0.410138990858948 1925 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2366 9070441 60.58 µM 0.227103255414784 0.420502611400184 no 1386 0.41017172636447 1852 6837235 SGTC_2669 eugenol 100 µM 0.226524107259475 0.420727959225908 no 1387 0.410396905795744 2015 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2749 bexarotene 57.39 µM 0.22651454209311 0.420731681271536 no 1388 0.410400625090098 1852 82146 An retinoic acid receptor inhibitor. SGTC_1307 1187-1599 12.2 µM 0.226405917498611 0.420773950316999 no 1389 0.41044286295955 1867 1538471 SGTC_2617 dihydrotanshinone i 20.83 µM 0.226132608399709 0.420880307017789 no 1390 0.4105491417733 1865 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2525 harmine 47.85 µM 0.224994238047109 0.421323359481061 no 1391 0.41099187836408 1963 5280953 A monoamine oxidase inhibitor SGTC_979 1426-2828 121 µM 0.224133517360015 0.421658417186185 no 1392 0.411326706380595 1971 747872 SGTC_100 0086-0128 49.5915 µM 0.223102370267307 0.422059892427519 no 1393 0.411727916819956 1814 93297 SGTC_1822 st052468 42 µM 0.221347037583692 0.422743514117408 no 1394 0.412411113727806 1911 2873678 SGTC_1561 5-methoxyflavone 52.9 µM 0.22124889578879 0.422781742740776 no 1395 0.412449319568095 2017 94525 SGTC_23 0213-0011 39.996 µM 0.220363124448121 0.423126805145251 no 1396 0.412794180977838 2016 627608 SGTC_1594 piperine 70.1 µM 0.220303891764395 0.423149882024623 no 1397 0.412817244713951 1864 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1020 4335-0961 93.3 µM 0.219350803536756 0.423521238595485 no 1398 0.413188394930717 1826 669075 SGTC_35 0133-0054 64.071 µM 0.216232926674398 0.42473654566161 no 1399 0.4144030944173 1852 99677 SGTC_1451 4152-0210 104 µM 0.215976366532306 0.424836581432889 no 1400 0.41450308479559 2026 659563 SGTC_3106 9121286 49.47 µM 0.215554837301622 0.425000951070209 no 1401 0.41466738137185 2022 15943471 SGTC_563 tetrahydrosecaminediol 614 µM 0.215161714881661 0.425154255606488 no 1402 0.414820619473496 2036 334274 A psychoactive constituent of the cannabis plant. SGTC_1748 st037455 53.6035 µM 0.215109658183738 0.425174556818885 no 1403 0.41484091201194 1933 580690 SGTC_2806 7952793 58.44 µM 0.214968513820828 0.425229601678922 no 1404 0.414895933498781 1939 2972490 SGTC_3048 9093155 49.47 µM 0.214948388343788 0.425237450528188 no 1405 0.41490377903257 2047 25236002 SGTC_2570 licareol 100 µM 0.211603827049447 0.426542224332102 no 1406 0.41620806169433 1891 443158 SGTC_1402 3909-7673 35.9 µM 0.210711000343058 0.426890668772982 no 1407 0.416556395145017 1950 5328014 SGTC_2262 9014885 67.46 µM 0.210226239028974 0.427079881010639 no 1408 0.41674555067212 2045 6457424 SGTC_3170 9103054 49.47 µM 0.20969556676012 0.427287032466525 no 1409 0.416952642912512 1922 16432970 SGTC_109 0132-0036 33.701 µM 0.20852123047903 0.427745513657777 no 1410 0.41741100371415 2054 67274 A color developer. SGTC_1970 st070122 35.8 µM 0.207517950709954 0.428137288749646 no 1411 0.41780268757343 2023 102928 SGTC_1469 k284-2957 126 µM 0.205988266084761 0.428734758201415 no 1412 0.418400038534627 1985 23884841 SGTC_1226 3909-7979 35.4 µM 0.205064624008425 0.429095596665986 no 1413 0.418760817507124 2027 6615510 SGTC_1821 st053465 65.6 µM 0.204810116721627 0.42919503523865 no 1414 0.41886024128198 1918 675086 SGTC_1030 k029-0042 36.7 µM 0.204411825776401 0.429350660557973 no 1415 0.419015844826637 1937 6080581 SGTC_2072 5231554 129 µM 0.203313911927888 0.429779708248102 no 1416 0.419444841232439 2116 789545 SGTC_199 4063-0024 41.6 µM 0.20219789564207 0.430215915095936 no 1417 0.419881009094785 2033 306215 SGTC_124 0136-0217 7.121 µM 0.202070553048127 0.430265693728827 no 1418 0.419930784121587 2110 3976905 SGTC_1378 2093-0007 380 nM 0.199597747266599 0.431232540301984 no 1419 0.420897594876707 1943 3618014 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.199333355449204 0.431335939806653 no 1420 0.421000994401948 1921 6312947 SGTC_538 2922-0838 53.3 µM 0.198650593287076 0.431602979159343 no 1421 0.421268037248325 2074 777039 SGTC_1893 st059353 36.1 µM 0.198132596046362 0.431805597141645 no 1422 0.421470661190427 1914 3112488 SGTC_1363 1636-0063 10.4 µM 0.197847852286347 0.43191698415659 no 1423 0.421582052697593 1945 6072185 SGTC_907 3448-6986 75.5 µM 0.196110365026047 0.432596777188197 no 1424 0.422261891834272 2044 590582 SGTC_3277 9138724 49.47 µM 0.195701576450263 0.432756745059714 no 1425 0.422421875221205 1980 15943418 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.192959624044231 0.433830014365338 no 1426 0.423495294560939 1933 688788 SGTC_143 4032-1194 15.74 µM 0.192938685729001 0.433838212037523 no 1427 0.423503493686616 1916 1806963 SGTC_3137 9097352 49.47 µM 0.192274999495768 0.434098070125837 no 1428 0.423763400264 2033 44120435 SGTC_404 fumagillin 50 µM 0.192200565634928 0.434127215556394 no 1429 0.423792551425021 1968 12015870 A methionine aminopeptidase binder. SGTC_1751 st044839 27.194 µM 0.190950753742907 0.434616647077713 no 1430 0.424282087971488 2092 5291326 SGTC_2788 5282734 71.43 µM 0.189342294757415 0.435246673673228 no 1431 0.424912274189781 2060 743706 SGTC_1668 st014914 51.6 µM 0.188696636574967 0.435499621594401 no 1432 0.425165293928732 2048 2839556 SGTC_2945 9067681 61.76 µM 0.186941925993951 0.4361871932876 no 1433 0.425853083209465 2059 16456930 SGTC_2780 5215298 71.43 µM 0.185144658929199 0.436891640405235 no 1434 0.426557787152934 2121 2834131 SGTC_3148 9097893 49.47 µM 0.184707192841181 0.437063137630905 no 1435 0.426729352092235 1892 17174100 SGTC_2820 7989630 71.43 µM 0.184640265397138 0.437089375842226 no 1436 0.426755600842564 2117 2984098 SGTC_1174 0739-0097 51.1 µM 0.184000369251217 0.437340254453603 no 1437 0.427006582623808 1979 728447 SGTC_3254 9136651 49.47 µM 0.183018882992085 0.437725106308045 no 1438 0.427391601187429 1995 16454030 SGTC_2841 9004761 38.96 µM 0.182637228441813 0.437874773300133 no 1439 0.427541335772322 1839 2991039 SGTC_3133 9127736 49.47 µM 0.182037083353813 0.438110139989339 no 1440 0.427776811884164 2129 27243420 SGTC_1898 st060199 18.6 µM 0.181101355051611 0.438477160356327 no 1441 0.428144010503862 1922 688866 SGTC_2545 solidagenone 89.61 µM 0.180065445649892 0.438883536424793 no 1442 0.428550594772415 2030 6708572 An anti ulcer agent SGTC_746 1095-0025 46.6 µM 0.179614482326414 0.439060464620433 no 1443 0.428727617170213 2040 6749286 SGTC_3083 9117465 49.47 µM 0.178475112258121 0.43950753227809 no 1444 0.429174932468704 1928 16420915 SGTC_357 1325-0123 420 µM 0.178236342461268 0.439601230910982 no 1445 0.429268684747943 2099 1098503 SGTC_2515 chrysin 20.77 µM 0.177914372594009 0.439727584477374 no 1446 0.42939511161404 2063 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1896 st058441 89 µM 0.177836037986784 0.439758326969584 no 1447 0.429425872106676 1943 688759 SGTC_828 2074-0507 139 µM 0.177831922384757 0.439759942151617 no 1448 0.429427488236234 2083 X828 SGTC_598 3937-0236 20.2 µM 0.177700384706222 0.439811565089557 no 1449 0.429479141552643 2041 1379313 SGTC_3212 9128307 49.47 µM 0.177653434379101 0.439829991341672 no 1450 0.429497578692444 1771 27243542 SGTC_3271 9137798 49.47 µM 0.177632650509143 0.439838148276999 no 1451 0.429505740454995 2092 6498326 SGTC_2300 7976697 71.57 µM 0.176488376132227 0.440287274892364 no 1452 0.429955139926795 1946 2236109 SGTC_763 3453-1109 128 µM 0.174776562033124 0.44095930359806 no 1453 0.430627602818411 2109 1560353 SGTC_908 3448-7491 47.7 µM 0.174498584748174 0.441068448788443 no 1454 0.43073682145617 1985 1203031 SGTC_3037 9091026 49.47 µM 0.174222013665782 0.441177046288875 no 1455 0.430845492847889 2062 25236398 YIL048W NEO1 SGTC_371 0195-0006 7.36 µM 0.173512451923781 0.441455680702672 no 1456 0.43112432055499 1983 3928593 SGTC_848 0368-0089 85.6 µM 0.170948374455154 0.442462796609475 no 1457 0.432132179572156 2099 762535 SGTC_1627 st003713 25.6 µM 0.169504106135469 0.443030239125398 no 1458 0.432700071433198 1981 16195070 YER133W GLC7 SGTC_2968 9090663 33.37 µM 0.168568593964995 0.443397857491236 no 1459 0.433067992691318 1970 25236811 SGTC_1269 0831-0796 3.05 µM 0.166461545649166 0.444226020050907 no 1460 0.433896871522924 2095 927758 SGTC_1717 st033143 58.0435 µM 0.165715301621783 0.444519385337092 no 1461 0.434190501802404 2098 674616 SGTC_1759 st043059 70 µM 0.165491443862301 0.444607394783655 no 1462 0.434278591895335 1964 669426 SGTC_955 1216-0110 33 µM 0.165029665087966 0.444788951253563 no 1463 0.434460316406554 2007 3619719 SGTC_629 3448-6466 76.7 µM 0.164690173666665 0.444922435684186 no 1464 0.434593925823356 2043 573744 SGTC_821 1114-0266 29.2 µM 0.164659476978656 0.444934505604867 no 1465 0.434606007105614 2011 3123235 SGTC_3242 9133940 49.47 µM 0.162723665664457 0.445695768202474 no 1466 0.435368006416236 2072 17248444 SGTC_2890 9046729 58.44 µM 0.16265566887609 0.445722511764928 no 1467 0.435394776580051 1966 903329 SGTC_2519 cryptotanshinone 88.04 µM 0.160642844811237 0.44651427940678 no 1468 0.436187353914284 2098 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.160270967198939 0.446660585205385 no 1469 0.436333814016682 1964 6708561 SGTC_268 camptothecin 39.6153 µM 0.159959271109102 0.446783219707028 no 1470 0.436456578982358 2133 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2521 angolensin 13.4 µM 0.158685034864102 0.447284611258335 no 1471 0.436958514610774 2035 821428 A flavenoid. SGTC_2666 tannic acid 100 µM 0.15867518263474 0.447288488282061 no 1472 0.436962395908406 2080 16134267 A thiamine antagonist. SGTC_1596 piperlongumine 63 µM 0.157888228584272 0.447598184635549 no 1473 0.437272436972493 2139 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3129 9127257 49.47 µM 0.157308131422176 0.447826495401487 no 1474 0.437501006049338 1888 837894 SGTC_2891 9063876 19.48 µM 0.156151280692005 0.448281852519169 no 1475 0.437956888966688 2186 6472478 SGTC_2160 5660466 132.927 µM 0.155517912095695 0.448531186624466 no 1476 0.438206516962544 2142 2859134 SGTC_1938 st074717 56.4 µM 0.152205918281066 0.449835326632476 no 1477 0.43951226311935 2107 17250979 SGTC_253 dyclonine 31.25 µM 0.15167191770941 0.450045647305684 no 1478 0.43972285365258 2067 3180 An oral anasthetic. SGTC_1027 k015-0025 8.67 µM 0.150200814609748 0.450625126186911 no 1479 0.440303091610486 2122 3598955 SGTC_2522 biochanin a 4.94 µM 0.148876698925297 0.451146795640543 no 1480 0.44082546392672 2105 5280373 A possible chelator. SGTC_1292 0kpi-0043 232 µM 0.148059810329908 0.451468672075941 no 1481 0.441147783254623 2030 3333905 SGTC_2830 7992007 71.43 µM 0.147356469393922 0.451745833202719 no 1482 0.441425331381003 1961 1952075 SGTC_446 go6976 132 µM 0.146807862633198 0.451962035544664 no 1483 0.441641839224361 2159 3501 A protein kinase C inhibitor. SGTC_2793 7325131 81.82 µM 0.146196669934332 0.452202919371288 no 1484 0.441883067162223 2059 4176441 SGTC_2738 aclarubicin 5.55 µM 0.145895500079053 0.452321623187494 no 1485 0.442001941998365 2113 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_55 0767-0285 6.563 µM 0.144706933514941 0.452790129189843 no 1486 0.442471132315422 2151 3116166 SGTC_3274 9138298 49.47 µM 0.144584170961272 0.452838523162479 no 1487 0.442519597821497 2173 17015756 SGTC_766 1391-0721 126 µM 0.143940242891673 0.453092376173871 no 1488 0.442773828664347 2138 1020919 YIL115C NUP159 SGTC_3114 9122766 49.47 µM 0.143512923018351 0.453260847250253 no 1489 0.442942552900703 2008 17176985 SGTC_2740 felodipine 17.08 µM 0.143258422805272 0.453361188087134 no 1490 0.443043045432251 2156 3333 L-type calcium channel blocker SGTC_3189 9110682 49.47 µM 0.142943915363494 0.45348519186004 no 1491 0.443167237615234 2036 17122418 SGTC_2477 5967686 25.23 µM 0.142519621514339 0.453652489324625 no 1492 0.443334790919697 2054 776118 SGTC_1699 st031318 29.054 µM 0.142100790897915 0.453817640724001 no 1493 0.443500196735444 2121 5340658 SGTC_2949 9072542 2.23 µM 0.142027479367924 0.453846549417894 no 1494 0.443529150153149 2047 16457352 SGTC_2694 st077685 81.9 µM 0.141453390279624 0.45407293651821 no 1495 0.443755889446105 2060 2838096 SGTC_3136 9095672 49.47 µM 0.139255599402811 0.454939753748531 no 1496 0.444624087243026 2191 17217380 SGTC_1675 st018485 24.5 µM 0.13886486125927 0.455093884971364 no 1497 0.444778469268075 2018 3323024 SGTC_2448 5185112 27.17 µM 0.138603160568159 0.455197119646085 no 1498 0.444881872824002 2035 5718189 SGTC_1483 3453-0561 55.9 µM 0.138070928109558 0.455407081970839 no 1499 0.445092180847049 2123 4546991 SGTC_387 norethindrone acetate 66.7 µM 0.137910174583776 0.455470500667768 no 1500 0.445155704547125 2035 541197 SGTC_2491 paeonol 100 µM 0.137876108296934 0.455483940266948 no 1501 0.445169166433311 2040 11092 Increases levels of cortical cytochrome oxidase. SGTC_966 1300-0360 30.2 µM 0.137495277177389 0.455634186627783 no 1502 0.445319662779631 2047 70588 SGTC_1186 1319-0216 26 µM 0.137061146144824 0.455805468730008 no 1503 0.445491231727169 2190 4565136 SGTC_1523 st012844 44.7 µM 0.136826805222011 0.455897929037458 no 1504 0.445583847700825 2045 4274103 SGTC_2151 5563267 85.4165 µM 0.136824580692888 0.455898806747283 no 1505 0.445584726891129 2037 5310824 SGTC_1567 st069303 68.4 µM 0.1365829148362 0.455994159666549 no 1506 0.445680240956844 2051 5581319 SGTC_1341 1486-1360 280 µM 0.136450239885972 0.4560465096531 no 1507 0.445732679675898 2021 3976547 SGTC_3331 9141060 1.957 µM 0.135850400198212 0.456283199859318 no 1508 0.445969773377808 2015 4906567 YPR165W RHO1 SGTC_3307 9126885 69.2785 µM 0.13463412557538 0.456763176107101 no 1509 0.446450579467852 2022 24824909 SGTC_1160 4092-0570 10.5 µM 0.134423082006935 0.456846466290202 no 1510 0.446534015235828 1995 4994975 SGTC_3050 9093513 49.47 µM 0.132936029869215 0.457433397906854 no 1511 0.447121986027515 2130 25236664 SGTC_3005 9076496 71.4286 µM 0.132184691745874 0.45772998248081 no 1512 0.447419104542724 2191 21368410 SGTC_1430 4049-0248 69.1 µM 0.13152868313801 0.457988955763875 no 1513 0.447678548902589 2172 22774488 SGTC_2059 5238311 157 µM 0.128033235825734 0.459369155637701 no 1514 0.449061335548034 2089 703021 SGTC_3279 9140807 49.47 µM 0.127912016903139 0.459417028593893 no 1515 0.449109300527881 2169 45595718 SGTC_235 0330-0087 5 mM 0.123896982582184 0.4610030133738 no 1516 0.450698421045736 2106 46494818 YHR062C RPP1 SGTC_944 3370-0224 231 µM 0.123329407213369 0.461227262816801 no 1517 0.450923127497512 2080 4580514 SGTC_1371 2421-0008 32.7 µM 0.122975523717515 0.461367088689282 no 1518 0.451063240036274 2070 2827552 SGTC_2030 5175110 200 µM 0.122281601987283 0.461641283765105 no 1519 0.451338001066344 2131 2831986 SGTC_1884 5633444 25 µM 0.122213786230208 0.461668081350458 no 1520 0.451364854234011 2113 5724239 SGTC_102 gallobenzophenone 83.616 µM 0.121198618497596 0.462069248442095 no 1521 0.451766859165638 2188 70837 SGTC_1120 ficusin 1.78878 µM 0.120753486250388 0.462245164975728 no 1522 0.451943146505881 2115 6199 A DNA cross-linker. SGTC_841 0251-0215 91.2 µM 0.119706623192995 0.462658914938583 no 1523 0.452357776771063 2126 3888614 SGTC_776 4476-4378 112 µM 0.119168583666623 0.462871579162335 no 1524 0.452570897926934 2044 2892008 SGTC_2816 7982706 58.44 µM 0.118967141322662 0.462951203517861 no 1525 0.452650694143625 2082 2981853 SGTC_226 1,3-diallylurea 8.28947 mM 0.118231999414594 0.463241796506221 no 1526 0.452941917950782 2142 74537 YKL182W FAS1 SGTC_359 0081-0058 15.9 µM 0.118190697176844 0.463258123380611 no 1527 0.452958280435325 2173 3494159 SGTC_2610 ononetin 44.17 µM 0.117269547117427 0.463622272256737 no 1528 0.453323228186199 2079 259632 SGTC_2714 st079313 56.9 µM 0.116969887060494 0.463740740402031 no 1529 0.453441958142266 2135 2939799 SGTC_1300 1094-0077 113 µM 0.116617965623825 0.46387987375955 no 1530 0.453581400179399 2095 5532636 SGTC_377 3970-0964 33.1 µM 0.116610530046636 0.46388281348843 no 1531 0.453584346444302 2137 16481235 SGTC_497 capsazepine 133 µM 0.116353087495769 0.463984597158548 no 1532 0.453686356770967 2106 2733484 A calcium channel blocker. SGTC_37 0566-0070 1.56 µM 0.116310236922363 0.464001538987199 no 1533 0.453703336393755 2176 1626686 SGTC_1390 3413-2614 145 µM 0.115622929542773 0.464273288564122 no 1534 0.45397569481889 2078 3421432 SGTC_1145 3546-0597 10.2 µM 0.115152156608394 0.464459433752282 no 1535 0.454162259911512 2109 875334 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.113423984214675 0.465142825263073 no 1536 0.454847212876554 2094 641818 YHR062C RPP1 SGTC_2995 9067767 71.4286 µM 0.113380636418478 0.465159968121626 no 1537 0.454864395305508 2115 11673567 SGTC_1233 0325-0408 14.2 µM 0.112496163629599 0.465509766804879 no 1538 0.455215005707875 2173 12874 SGTC_646 4092-0839 27.3 µM 0.111235136802365 0.466008534243109 no 1539 0.455714944687301 2166 877796 SGTC_2339 9000433 200 µM 0.11016834855005 0.466430517222172 no 1540 0.456137931821176 2053 2988954 SGTC_169 k015-0017 16.025 µM 0.10988023483527 0.466544491114885 no 1541 0.456252178965695 2184 1840002 SGTC_2557 derrustone 83.84 µM 0.1088022335061 0.466970958136352 no 1542 0.456679676128085 2031 629853 An antioxidant. SGTC_2425 5628681 7.85 µM 0.106782985951714 0.467769892288625 no 1543 0.457480572767008 2168 5714958 SGTC_2289 7946404 165.07 µM 0.105862707328811 0.468134052387002 no 1544 0.457845641495546 2146 1246120 YPR165W RHO1 SGTC_2149 5554786 194.827 µM 0.105199530085362 0.468396492386071 no 1545 0.458108741796032 2109 745063 YPR165W RHO1 SGTC_1471 k673-0312 37 µM 0.103477080157791 0.469078183631247 no 1546 0.458792169608739 2225 24099884 SGTC_1924 st058459 75.1 µM 0.103432600527638 0.469095788472515 no 1547 0.458809819706986 2246 688683 SGTC_2812 7970281 58.44 µM 0.102637174160473 0.469410624886724 no 1548 0.459125468956903 2213 2233435 SGTC_1235 benzylparaben 21.5 µM 0.101951939696918 0.469681861766562 no 1549 0.459397411395611 2168 7180 SGTC_2486 5283202 22.39 µM 0.101742547036929 0.469764748635057 no 1550 0.459480514850804 2094 1377751 SGTC_1611 st001856 99.4 µM 0.101307465892186 0.46993697716502 no 1551 0.45965319488157 2058 647478 SGTC_234 nsc-17383 10.7 µM 0.10120728773892 0.469976633866721 no 1552 0.459692955823496 2215 408974 SGTC_300 r073-0011 5.04 µM 0.100840992700847 0.470121638603329 no 1553 0.459838342604522 2248 2735780 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.100758637795842 0.470154240877872 no 1554 0.459871030968826 2213 23665772 A membrane-active detergent. SGTC_3233 9132340 49.47 µM 0.0997844908600879 0.470539896730125 no 1555 0.460257710546215 2135 17682950 SGTC_3064 1327-0027 10 µM 0.0996227357044573 0.470603936799997 no 1556 0.460321921567522 2164 16000455 YPR107C YTH1 SGTC_1640 st009078 66.4 µM 0.0985652254162271 0.471022631650096 no 1557 0.460741740813473 2225 690618 SGTC_867 0518-0118 155 µM 0.0980603101653876 0.471222551590102 no 1558 0.460942201740722 2249 6848158 SGTC_1105 epirubicin 18.1 µM 0.0978046224217542 0.471323793286657 no 1559 0.461043718411455 2099 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2933 9026794 32.47 µM 0.0971790709827721 0.471571493401013 no 1560 0.461292094152307 2185 17586027 SGTC_116 0155-0182 31.788 µM 0.0950460764054604 0.472416179108049 no 1561 0.462139114435744 2080 771486 SGTC_3151 9099821 49.47 µM 0.0947094002288984 0.472549517442472 no 1562 0.462272825620668 2158 17174189 SGTC_1017 4239-0030 168 µM 0.0946656543267455 0.47256684293882 no 1563 0.462290199650383 2047 1149593 SGTC_2844 9010103 25.97 µM 0.0946298769832657 0.472581012538513 no 1564 0.462304408957722 2129 2480525 SGTC_2966 9084041 48.03 µM 0.094567914490122 0.472605552836223 no 1565 0.462329018056506 2178 17741380 SGTC_837 0091-0265 12.5 µM 0.0945143916991247 0.472626750666483 no 1566 0.462350275349049 2114 759367 SGTC_1807 st050092 58.9 µM 0.0942015684215779 0.472750646627653 no 1567 0.462474519448083 2160 5008496 SGTC_2919 7978188 46.38 µM 0.0941483474431512 0.472771725450568 no 1568 0.462495657602109 2234 2980291 SGTC_2539 epi(13)torulosol 80 µM 0.0937184341311265 0.472942000694705 no 1569 0.462666413204198 2141 6708597 SGTC_1552 6-methylflavone 10.6 µM 0.0934988151699574 0.473028986820386 no 1570 0.462753645465149 2250 689013 SGTC_2840 9008771 71.43 µM 0.0934426030000272 0.473051251402148 no 1571 0.462775973127194 2236 2992978 SGTC_2373 9071805 200 µM 0.0933826302788849 0.473075005560243 no 1572 0.462799794622076 2276 10149009 SGTC_2667 digitoxin 100 µM 0.0929543553115488 0.473244640649513 no 1573 0.462969911669015 2255 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2340 7987427 183.45 µM 0.0924180018471313 0.473457091304048 no 1574 0.46318296861528 2187 2239331 SGTC_786 4544-0069 423 µM 0.092358753385611 0.473480560199508 no 1575 0.463206504669658 2164 748821 YLR208W SEC13 SGTC_2993 9054257 71.4286 µM 0.0923026987276485 0.473502764082861 no 1576 0.463228772125537 2242 6470217 YGL055W OLE1 SGTC_2908 7930301 100 µM 0.0915074567344726 0.473817777257249 no 1577 0.46354469074001 2245 2223178 SGTC_9 0092-0002 10.449 µM 0.0907683322429998 0.474110575716041 no 1578 0.463838336678998 2250 759368 SGTC_2468 5987765 72.9 µM 0.0900267494655604 0.47440436206112 no 1579 0.464132979066977 2164 26772094 SGTC_1214 0358-0031 63.7 µM 0.0895570340358351 0.47459045231392 no 1580 0.464319614509417 2246 4301366 SGTC_2406 ethylparaben 405.7 µM 0.0895314713275332 0.474600579819715 no 1581 0.46432977175156 1889 8434 A possible steroid mimic. SGTC_1983 st071813 46.9 µM 0.0887930945075304 0.474893119086357 no 1582 0.46462317289955 2121 11838595 SGTC_799 1310-0557 151 µM 0.0861371677111865 0.475945487823486 no 1583 0.465678688924124 2157 5354492 SGTC_866 0495-0101 262 µM 0.0859337825731721 0.476026082959074 no 1584 0.465759528110411 2048 635694 SGTC_3029 9088683 49.47 µM 0.0851519582929979 0.47633590444286 no 1585 0.466070291761777 2186 25236615 SGTC_165 k038-0023 64.381 µM 0.085006369682448 0.476393599912578 no 1586 0.466128163383706 2238 46368543 SGTC_1496 4469-0713 57.4 µM 0.0849004029004273 0.476435593915793 no 1587 0.466170285738616 2260 746691 SGTC_1278 0874-0585 172 µM 0.08355307698751 0.476969553792852 no 1588 0.466705887778085 2184 766306 SGTC_2036 5160441 105 µM 0.0825981411036576 0.477348030341469 no 1589 0.467085539705153 2187 134534 YIL048W NEO1 SGTC_2179 6298986 200 µM 0.0802820919896804 0.478266050803465 no 1590 0.468006450379002 2258 738374 SGTC_1912 st060209 90.8 µM 0.0801657530505366 0.47831216755706 no 1591 0.468052713788046 2168 688787 SGTC_675 1309-0189 238 µM 0.0798850859351393 0.47842342519118 no 1592 0.468164325808469 2167 4246530 SGTC_3325 9138760 55.175 µM 0.079755038380478 0.478474977163606 no 1593 0.468216042264719 2196 43844959 SGTC_1697 st025554 27.742 µM 0.0791584516678285 0.478711473884784 no 1594 0.468453295806282 2253 1269519 SGTC_1604 st002052 72.4 µM 0.0774706961361563 0.479380568079492 no 1595 0.469124551145579 2190 6254834 YHR062C RPP1 SGTC_1767 st044992 70.3 µM 0.0747399127031053 0.480463282748344 no 1596 0.470210825359929 2222 9600693 SGTC_2303 7774051 200 µM 0.0747218390197837 0.480470449181653 no 1597 0.470218015610601 2240 2953184 SGTC_576 1073-0113 22.7 µM 0.0738720162133459 0.480807421254681 no 1598 0.470556111409791 2296 5439563 SGTC_518 1021-0119 62.6 µM 0.07326171656706 0.481049425985352 no 1599 0.470798927777548 2097 1097762 SGTC_742 0kpi-0133 140 µM 0.0727449984823397 0.481254327882366 no 1600 0.471004519885158 2254 2728852 SGTC_2781 5567276 71.43 µM 0.0723458203853206 0.481412623295799 no 1601 0.471163350404513 2251 2853274 SGTC_2133 5320837 200 µM 0.0722352565726861 0.481456468265941 no 1602 0.471207343880481 2260 2841355 SGTC_695 3505-6186 243 µM 0.0714421131818887 0.481771002207898 no 1603 0.471522946872192 2235 1819379 SGTC_195 4234-0266 16.654 µM 0.0714068046140242 0.481785004661378 no 1604 0.471536997068816 2163 2303354 SGTC_1704 st028805 70.8 µM 0.0703957244274721 0.482185982056152 no 1605 0.471939347110314 2168 2876101 SGTC_1270 0831-1170 17.3 µM 0.0701728062460737 0.482274390095973 no 1606 0.472028059213458 2279 6764716 SGTC_177 1327-0068 8.361 µM 0.0701550713389347 0.482281423693339 no 1607 0.472035117023632 2291 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_983 1491-0821 12.2 µM 0.067951860590648 0.483155250976715 no 1608 0.47291197766976 2277 46495113 SGTC_3019 9081971 49.47 µM 0.0678334551933222 0.483202214707884 no 1609 0.472959105847076 2269 16451803 SGTC_2650 prasterone 100 µM 0.0677741446822447 0.483225739423304 no 1610 0.472982712989985 2272 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1460 k062-0059 9.15 µM 0.0671824793467448 0.483460418693554 no 1611 0.473218216532144 2258 1373085 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0668205310438008 0.483603985390726 no 1612 0.47336228926374 2219 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_399 oxolinic acid 75 µM 0.0666952345032055 0.483653684726171 no 1613 0.473412164090975 2164 4628 A DNA gyrase inhibitor. SGTC_3058 9093861 49.47 µM 0.0641960181855473 0.484645060144368 no 1614 0.474407073942358 2260 17217477 SGTC_1367 1812-0510 76.9 µM 0.0636788309719528 0.484850227187375 no 1615 0.47461298048365 2254 1142582 YDR527W RBA50 SGTC_3263 9137018 49.47 µM 0.0633267505434886 0.484989899025598 no 1616 0.474753157327928 2214 43844957 SGTC_134 0269-0018 6.916 µM 0.0622958088298187 0.485398888618009 no 1617 0.475163633032794 2220 4378915 SGTC_2602 kawain 100 µM 0.0615122133396676 0.485709762658552 no 1618 0.475475643993847 2310 5369129 SGTC_3179 9107801 49.47 µM 0.0614834027989356 0.485721192764947 no 1619 0.475487116022648 2278 4818259 SGTC_2741 miltefosine 3.04 µM 0.0600727049614033 0.486280878009163 no 1620 0.47604886448816 2264 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2646 retinol 96.75 µM 0.0598656233681881 0.486363038593149 no 1621 0.476131329672842 2269 445354 A vitamin A analog and teratogen. SGTC_2368 9071271 200 µM 0.0595682749422206 0.486481013973751 no 1622 0.476249743205109 2240 27209959 SGTC_529 4076-0302 30.3 µM 0.0588780654798221 0.48675486467482 no 1623 0.476524614474095 2142 5816522 SGTC_2127 5253358 187.912 µM 0.0558424919641441 0.487959345279673 no 1624 0.477733642022231 2281 20612 SGTC_2878 9043973 25.97 µM 0.0557539026009257 0.487994498221363 no 1625 0.477768929089958 2286 6465167 SGTC_69 0096-0274 206.684 µM 0.0548881713513279 0.488338031916965 no 1626 0.478113777783766 2259 6741392 SGTC_1276 0871-0068 94.2 µM 0.0548099245368219 0.488369081725761 no 1627 0.478144946826336 2295 3414906 SGTC_251 melphalan 456.522 µM 0.0538923774782364 0.488733186879041 no 1628 0.478510454866491 2243 460612 A DNA alkylator. SGTC_1686 st019653 115.5 µM 0.0531805350657841 0.489015669872896 no 1629 0.478794032216575 2322 97252 SGTC_722 3534-0461 190 µM 0.0522838814681097 0.489371499980747 no 1630 0.479151248237436 2267 658262 SGTC_1352 1496-0991 99 µM 0.0520555409088116 0.4894621165443 no 1631 0.479242219059724 2290 3000039 SGTC_2172 5754775 163.918 µM 0.0509013265789313 0.489920172770043 no 1632 0.479702074212435 2272 2263357 SGTC_1616 st002734 56.1 µM 0.0501946702093298 0.49020061978823 no 1633 0.479983629379444 2222 4026101 SGTC_922 1866-0035 480 µM 0.0498450568311016 0.490339370821437 no 1634 0.480122930563199 2176 3156169 SGTC_2308 7584454 197.62 µM 0.0494257836358834 0.490505769280768 no 1635 0.480289990449159 2296 893577 SGTC_2466 5983409 37.09 µM 0.0493343336396055 0.490542063589859 no 1636 0.480326429266084 2198 2879657 SGTC_2068 5226020 147 µM 0.0492592160080871 0.490571876033882 no 1637 0.480356360474197 2289 1810509 SGTC_3039 9090270 49.47 µM 0.0491454537766871 0.490617025722657 no 1638 0.480401690136365 2326 17173750 SGTC_3158 9100007 49.47 µM 0.0490116356914192 0.490670135285727 no 1639 0.48045501157197 2283 19297233 SGTC_1200 1643-0193 18.4 µM 0.0488368260893046 0.490739513762447 no 1640 0.480524667100228 2314 5403974 SGTC_544 k015-0020 52.4 µM 0.0478851438163448 0.491117222510664 no 1641 0.480903889662741 2260 3008304 SGTC_383 2324-0395 7.37 µM 0.0471572659298798 0.491406111971125 no 1642 0.481193943226363 2295 3146421 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0467651260803615 0.491561751314929 no 1643 0.48135021198217 2315 16486 A toxic proline analog. SGTC_3255 9139072 49.47 µM 0.0441204343359479 0.492611455342228 no 1644 0.482404202199485 2248 17646060 SGTC_29 0299-0004 12.984 µM 0.0438353355973016 0.492724617005119 no 1645 0.482517830205519 2316 16871 A napthoquinone isolated from Swertia calycina. SGTC_2382 9035899 200 µM 0.0434338318155397 0.492883983259399 no 1646 0.482677854624796 2332 6462679 SGTC_58 0957-0393 9 µM 0.0428734133056553 0.493106428384576 no 1647 0.482901221182804 2320 6997992 SGTC_3313 9133968 57.047 µM 0.0418757376163368 0.493502437862813 no 1648 0.483298879002497 2332 1494643 SGTC_1889 st059080 5.18 µM 0.0412634217552047 0.493745488862123 no 1649 0.483542946715366 2331 176925 Isolated from Daphnopsis sellowiana. SGTC_1768 st044301 37.178 µM 0.0409833840229719 0.49385664706022 no 1650 0.483654571180602 2325 3931349 SGTC_1692 fluoroquinolonic acid 71 µM 0.0408004003224319 0.493929280882039 no 1651 0.483727510107472 2289 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0407630031562608 0.493944125393561 no 1652 0.483742417016876 2284 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0400155646056783 0.494240816989854 no 1653 0.484040358735335 2301 115019 SGTC_1932 st074806 40.9 µM 0.0389126659262322 0.494678612288298 no 1654 0.484480009134596 2286 17251235 SGTC_2100 5377183 190 µM 0.0384764601435826 0.494851765840322 no 1655 0.484653899833538 2313 2844202 SGTC_1158 4092-0494 91.8 µM 0.0380323228023373 0.495028068851203 no 1656 0.484830955396983 2285 1148199 SGTC_2306 7482397 179.52 µM 0.0378784175205865 0.495089162714399 no 1657 0.484892310510671 2331 891448 SGTC_354 2783-3500 4.88 µM 0.0376387218876337 0.49518431193386 no 1658 0.484987867090604 2306 6740761 SGTC_2078 5212016 200 µM 0.0367571230961661 0.495534272385022 no 1659 0.485339330869708 2354 1899708 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0359015231876136 0.49587391557905 no 1660 0.485680440661934 2338 6710655 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0358378960256585 0.495899173456149 no 1661 0.485705807902562 2325 107982 A Capsaicinoid. SGTC_1196 1588-0294 184 µM 0.035563561996815 0.496008075171506 no 1662 0.485815181622361 2273 6144269 SGTC_2575 plumbagin 510 nM 0.035419171744201 0.496065393540571 no 1663 0.485872748730704 2328 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_718 1130-0073 349 µM 0.0341797934612989 0.49655739078533 no 1664 0.48636688980355 2308 6740020 SGTC_2855 9016525 58.44 µM 0.0334671711796856 0.496840283588867 no 1665 0.486651022381334 2347 43811474 SGTC_1940 st075990 51.1 µM 0.0334003211409168 0.4968668214267 no 1666 0.486677676786724 2287 1084979 SGTC_447 ml7 120 µM 0.032435207891899 0.497249949375887 no 1667 0.48706249270645 2350 4216 Selective myosin light chain kinase inhibitor. SGTC_2452 5863136 48.41 µM 0.0301493004302305 0.498157411980513 no 1668 0.487973991262322 2345 2184096 SGTC_1208 2323-2347 50.3 µM 0.0297443720720349 0.498318162110583 no 1669 0.488135461883125 2347 5412760 SGTC_1740 st038286 13.222 µM 0.0295038272028432 0.498413654736025 no 1670 0.488231383302604 2328 716786 SGTC_372 0155-0182 15.9 µM 0.0284778499402158 0.498820952934461 no 1671 0.48864051702528 2306 771486 SGTC_3243 9134147 49.47 µM 0.0268421911051935 0.499470288304791 no 1672 0.489292800846877 2364 24282180 SGTC_1061 3448-9325 110 µM 0.0265930384861357 0.49956919883303 no 1673 0.489392162890455 2365 723482 SGTC_1114 scopoletin 1.73284 µM 0.0262295004114159 0.499713519027467 no 1674 0.48953714302356 2362 5280460 A coumarin with genotoxic properties. SGTC_804 1595-0054 20.9 µM 0.0262036777195918 0.499723770323723 no 1675 0.48954744124748 2324 761523 Stimulates phospholipase C. SGTC_1845 st056753 3.01 µM 0.026153839686997 0.499743555420241 no 1676 0.489567316934009 2349 5375839 SGTC_962 1254-0300 21.5 µM 0.0257241804527824 0.49991412496371 no 1677 0.489738668512253 2346 7340576 SGTC_1050 3232-1156 69.3 µM 0.025556905470012 0.499980531124068 no 1678 0.489805379642454 2326 700529 SGTC_1600 coumarin 106 71.1 µM 0.0254588225259724 0.499980531124068 no 1679 0.489844496348067 2331 100336 A hepatotoxic, DNA x-linker. SGTC_463 ikarugamyin 104 µM 0.0231219509678856 0.499052822045679 no 1680 0.490776498012732 2364 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1916 st067606 49.2 µM 0.0225689981165867 0.498833307171802 no 1681 0.490997036722557 2354 19590279 SGTC_1804 st050076 49.1 µM 0.0222353485065828 0.498700852913268 no 1682 0.491130110262052 2351 3895976 SGTC_3226 9131256 49.47 µM 0.0214461357568839 0.498387547015571 no 1683 0.491444885502287 2363 17178073 SGTC_230 MPP+ 141.667 µM 0.020885463296922 0.498164968857102 no 1684 0.491668511352292 2315 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_949 1165-0505 146 µM 0.0205938540366176 0.49804920478335 no 1685 0.491784821598019 2353 6244267 SGTC_703 3875-0075 71.8 µM 0.0205774036693007 0.498042674263254 no 1686 0.491791382954675 2350 2850814 SGTC_2148 5546263 113.568 µM 0.0201768325812394 0.497883654421452 no 1687 0.491951154522768 2366 792097 SGTC_621 3584-0052 32.1 µM 0.0194632769174407 0.497600385928176 no 1688 0.49223576613231 2364 2273927 SGTC_2520 obtusaquinone 4.71 µM 0.0191063748304996 0.497458702799541 no 1689 0.492378122989959 2360 5967872 SGTC_2165 5727197 32.143 µM 0.0185149110572389 0.497223903996251 no 1690 0.492614041150633 2324 1361712 SGTC_770 0389-1121 67.2 µM 0.0176023190093966 0.496861625869515 no 1691 0.492978053331149 2369 6753108 SGTC_2328 6201408 200 µM 0.0159814694789726 0.4962181923262 no 1692 0.493624587510934 2363 2890418 SGTC_1620 st003704 16.5 µM 0.0157511372094084 0.496126757387602 no 1693 0.493716465226244 2367 2834414 SGTC_2360 9040895 200 µM 0.0156758056775881 0.496096853093762 no 1694 0.493746514449324 2356 4914414 SGTC_2768 sulfasalazine 50.2 µM 0.015222680367456 0.495916976795113 no 1695 0.493927263720485 2383 5384001 An antioxidant and salicylic acid derivative. SGTC_1722 st034304 3.6505 µM 0.0143865076036861 0.495585045078538 no 1696 0.494260811825083 2361 4036148 YLR033W RSC58 SGTC_2383 9036125 200 µM 0.0135961230014828 0.495271292487409 no 1697 0.494576098791164 2366 79580 SGTC_2684 capsaicin 100 µM 0.0126569860325928 0.494898494689273 no 1698 0.494950727944479 2365 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1428 4049-0204 61.7 µM 0.0122173857624048 0.494723993419269 no 1699 0.495126089514018 2388 X1428 SGTC_1818 st052136 56.3 µM 0.01163694748135 0.494493587430426 no 1700 0.495357634412182 2372 674169 SGTC_3167 9103034 49.47 µM 0.0110177772332149 0.494247808746387 no 1701 0.495604631752468 2383 5127859 SGTC_1364 1653-0028 37.6 µM 0.0109294409819206 0.494212743982204 no 1702 0.495639870696188 2368 5718652 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0109021343023952 0.494201904700867 no 1703 0.495650763836185 2382 140250 A respiratory chain inhibitor. SGTC_187 1488-2104 32.728 µM 0.00984300361040506 0.493781490229958 no 1704 0.496073273100407 2370 2852859 SGTC_2762 leflunomide 42.06 µM 0.00980966893408246 0.493768258374566 no 1705 0.496086571070174 2394 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1076 itraconazole 331 nM 0.00976370229319642 0.493750012402589 no 1706 0.49610490822853 2388 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1917 st066507 28.5 µM 0.00965786617432966 0.493708001924255 no 1707 0.49614712874039 2349 3156428 SGTC_1258 0671-0043 57.1 µM 0.00903550863199522 0.493460965399332 no 1708 0.496395402628637 2374 4298767 SGTC_332 4112-0506 40.9 µM 0.00797003302692656 0.493038044943995 no 1709 0.496820450510985 2389 2790355 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.00791470292299498 0.493016082911946 no 1710 0.496842523332619 2394 616764 SGTC_819 1013-0258 27.7 µM 0.00715707675908221 0.492715362517135 no 1711 0.497144763852727 2385 5753198 SGTC_2254 7938975 95.19 µM 0.00693070451832744 0.492625510621674 no 1712 0.497235071070094 2394 2969277 SGTC_2119 5528445 120.635 µM 0.00624032715448804 0.49235148768004 no 1713 0.497510485812193 2391 791935 SGTC_1311 1190-0148 100 µM 0.00495265532016373 0.491840397781382 no 1714 0.49802418446993 2390 1961333 SGTC_2083 5306046 65.942 µM 0.00450446670292422 0.491662510312469 no 1715 0.498202983858521 2396 539837 SGTC_3132 9126706 49.47 µM 0.00369218896664979 0.491340118979686 no 1716 0.498527033060617 2388 850858 SGTC_1441 4106-0040 13 µM 0.00174156856481171 0.490565945331983 no 1717 0.499305215016499 2398 2904180 SGTC_1397 3532-0190 20.1 µM 0.000676727506610147 0.490143339786497 no 1718 0.499730024805909 2402 5322280 SGTC_220 paclitaxel 373.376 µM -0.000811168563736224 0.489552854211344 no 1719 0.499676390598882 2397 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1899 st063254 59.6 µM -0.00144747825086098 0.489300335630923 no 1720 0.499422539927418 2408 3093813 SGTC_971 1315-0384 26.7 µM -0.00177841631624377 0.489169005026529 no 1721 0.499290514913284 2410 6769120 SGTC_2284 7945075 39.21 µM -0.00203762016332126 0.489066142496359 no 1722 0.49918710772796 2411 1245402 SGTC_1485 3909-9022 254 µM -0.0025478293086353 0.488863673081576 no 1723 0.498983564265227 2412 714516 SGTC_1944 st076371 56.9 µM -0.00287258768818415 0.488734798719544 no 1724 0.498854004893102 2414 24208455 SGTC_317 4495-0002 170 µM -0.00411944966040057 0.48824001563048 no 1725 0.498356582006579 2417 15991618 SGTC_666 0272-0154 136 µM -0.00421080948182068 0.488203762685201 no 1726 0.498320135027246 2413 6870312 SGTC_2745 rifampicin 24.3 µM -0.00514108319497046 0.487834621746029 no 1727 0.497949013581316 2414 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1236 0330-0013 258 µM -0.00612947136119161 0.487442431897552 no 1728 0.497554710029282 2425 4617066 SGTC_1696 st025591 34.7925 µM -0.00662608810452581 0.487245380228021 no 1729 0.497356592644606 2416 2787147 SGTC_188 3229-0966 278.469 µM -0.00878287221822095 0.48638963046497 no 1730 0.496496185975541 2425 5722370 SGTC_649 1123-0311 367 µM -0.0106242242054477 0.485659084515576 no 1731 0.495761627501908 2426 693629 YIL048W NEO1 SGTC_1492 4158-0558 28.5 µM -0.0116926618958886 0.485235209834278 no 1732 0.495335409088723 2433 3967268 SGTC_1425 4048-4433 7.33 µM -0.011772340331571 0.485203600163475 no 1733 0.495303624179598 2428 23734946 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0121082787288242 0.485070329217483 no 1734 0.495169613703297 2426 77254 SGTC_750 4073-0104 132 µM -0.0121697365722583 0.485045948305602 no 1735 0.495145097377467 2434 22330957 SGTC_16 erodoxin 22.806 µM -0.0123845446476035 0.48496073233582 no 1736 0.495059407812365 2439 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1775 st081588 35.1725 µM -0.0128959819751519 0.48475784409516 no 1737 0.494855390140095 2430 1426443 YGL099W LSG1 SGTC_3200 9114385 49.47 µM -0.0133711952436385 0.484569329548834 no 1738 0.494665823826832 2446 17018030 YLR208W SEC13 SGTC_1319 1306-0155 43.7 µM -0.0141146621984695 0.48427440714328 no 1739 0.494369251439151 2433 3122360 SGTC_1742 st038235 28.8875 µM -0.0160207543445219 0.483518328109886 no 1740 0.493608917123304 2463 564103 YBR002C RER2 SGTC_2848 9016370 25.97 µM -0.0167399050899478 0.483233081810626 no 1741 0.493322055978337 2436 7894410 SGTC_2274 7947094 46.08 µM -0.0173152185917733 0.483004893756903 no 1742 0.493092572371542 2434 2971028 SGTC_933 2914-0560 114 µM -0.0177738353839248 0.482822995399123 no 1743 0.492909638900835 2441 463887 SGTC_2732 terfenadine 20 µM -0.0184030499098469 0.4825734397366 no 1744 0.492658659689665 2432 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2205 7238770 200 µM -0.0204237418973405 0.481772050466151 no 1745 0.491852672251845 2437 279867 SGTC_761 k216-0224 480 µM -0.0223953884485956 0.48099018316352 no 1746 0.491066279457771 2447 1340404 SGTC_51 1013-0126 23.419 µM -0.0229910565976481 0.480753981922378 no 1747 0.490828703433143 2434 1627850 SGTC_2747 doxorubicin 7.63 µM -0.0232367676976869 0.480656551671738 no 1748 0.490730705068273 2442 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2243 6634756 200 µM -0.0236873360435078 0.480477893694349 no 1749 0.490551003773137 2452 885676 SGTC_1831 st055328 12 µM -0.0237637200619149 0.480447606525599 no 1750 0.490520539534032 2450 1103068 SGTC_2712 st079126 47.7 µM -0.0239444876272711 0.480375930493088 no 1751 0.490448444224077 2443 3152970 SGTC_1098 clofazimine 15.1 µM -0.0254704143030707 0.479770911788072 no 1752 0.48983987339719 2512 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2015 5119600 184 µM -0.026006462618353 0.479558383562877 no 1753 0.489626091885795 2468 2828786 SGTC_466 geldanamycin 89.2 µM -0.0260784997111047 0.479529823303849 no 1754 0.489597362987522 2458 5288382 HSP90 inhibitor. SGTC_2497 7-hydroxyflavone 100 µM -0.026123362471543 0.479512036797135 no 1755 0.489579471430995 2457 5281894 SGTC_532 1548-0774 215 µM -0.0262750150081631 0.479451912202154 no 1756 0.489518991582436 2484 5932993 SGTC_2943 9068529 45.32 µM -0.0264582660697252 0.479379260590259 no 1757 0.48944591039358 2444 3270634 SGTC_22 0964-0034 14.468 µM -0.0268039974864432 0.479242193976413 no 1758 0.489308032415859 2461 138402 SGTC_1060 3448-7350 82 µM -0.027688876022579 0.478891391533454 no 1759 0.48895514797571 2461 570178 SGTC_144 4161-2749 112.381 µM -0.0278268705251339 0.478836686273267 no 1760 0.488900117338846 2442 797501 YMR168C CEP3 SGTC_2837 9008476 45.46 µM -0.0284369337461953 0.478594843261928 no 1761 0.488656833616912 2506 2992805 SGTC_1578 josamycin 24.2 µM -0.0289219985923295 0.478402558084783 no 1762 0.488463400309895 2466 5282165 A P450 substrate. SGTC_3251 9135047 49.47 µM -0.030127743585453 0.477924609041757 no 1763 0.48798258729423 2478 17682963 SGTC_2367 9070478 135.38 µM -0.0322752669072695 0.477073424600404 no 1764 0.487126266537601 2475 572802 SGTC_3044 9093193 49.47 µM -0.0323401103722717 0.477047725090376 no 1765 0.487100411235042 2501 25236277 SGTC_2318 6029776 164 µM -0.0323720597798599 0.477035062567718 no 1766 0.487087671935757 2482 818325 SGTC_912 3474-0017 2.18 µM -0.0324192265211439 0.477016368994938 no 1767 0.487068864999751 2496 3360550 SGTC_792 4534-1957 155 µM -0.0333980486258818 0.47662844435876 no 1768 0.486678582883535 2526 1717904 SGTC_2909 7941780 10.49 µM -0.0348919650933607 0.476036421472285 no 1769 0.486082943820132 2463 1243215 SGTC_1207 2099-0101 141 µM -0.0351646799989418 0.475928353185295 no 1770 0.485974213040033 2470 5837381 SGTC_211 3455-0679 143.504 µM -0.035849572039328 0.475656959967926 no 1771 0.485701152838355 2497 748649 SGTC_2649 anisomycin 9.56 µM -0.0363036212794731 0.475477046027203 no 1772 0.485520131240659 2485 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1830 st055982 50.3 µM -0.0364142490264822 0.475433211286735 no 1773 0.485476026317391 2459 455313 An antimicrobial agent. SGTC_1489 4065-0444 182 µM -0.0383990854524013 0.474646797875208 no 1774 0.484684745074515 2466 2877968 SGTC_588 3970-1144 52.9 µM -0.0384070459043369 0.474643644055868 no 1775 0.484681571654603 2506 1888707 SGTC_2475 5812728 15.03 µM -0.0387887294571028 0.474492428256946 no 1776 0.484529415331829 2459 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_400 oxethazaine 37.5 µM -0.0394095892646827 0.474246463212948 no 1777 0.484281917361227 2512 4621 A local anesthetic. SGTC_3208 9114115 49.47 µM -0.0399943839355697 0.474014795012891 no 1778 0.4840488018413 2518 650895 SGTC_648 0375-0473 33.3 µM -0.0403909039083693 0.473857717405451 no 1779 0.483890740981335 2483 1713139 SGTC_3152 9099253 49.47 µM -0.0404260841594374 0.473843781280279 no 1780 0.483876717545483 2513 25236131 SGTC_224 benfluorex 43.875 µM -0.0406207155262317 0.473766681582509 no 1781 0.483799134591724 2475 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_773 4358-1457 44.6 µM -0.0417827693529236 0.473306375511106 no 1782 0.483335935540648 2470 1186886 SGTC_204 PMA1.184 62.41 µM -0.0419934653876531 0.473222919609885 no 1783 0.483251953694443 2465 2252213 YGL008C PMA1 SGTC_1452 4194-0072 190 µM -0.0433997410728803 0.472665929416423 no 1784 0.482691442051108 2495 1343545 SGTC_1303 1160-0052 261 µM -0.043550064394384 0.472606393297464 no 1785 0.48263152836969 2483 3562476 SGTC_27 0485-0001 32.618 µM -0.0439264749541197 0.4724573171621 no 1786 0.482481505851415 2473 2054479 SGTC_2353 9059630 146.67 µM -0.0440269672567115 0.47241751817551 no 1787 0.482441453971011 2523 4779114 SGTC_2935 9038016 29.96 µM -0.0444147369597482 0.472263948389199 no 1788 0.482286907422907 2484 6463195 SGTC_2173 5763948 167 µM -0.0459647065607496 0.471650149933878 no 1789 0.481669190123244 2494 2867177 SGTC_1548 st061468 90.8 µM -0.0460891164775954 0.471600885664224 no 1790 0.481619610292025 2501 390799 SGTC_1972 st070201 17.4 µM -0.0467691541129458 0.471331609705456 no 1791 0.48134860678604 2505 2829099 SGTC_1987 st072290 61.9 µM -0.046988513276057 0.471244752377515 no 1792 0.481261191247537 2545 54697379 SGTC_1907 st060210 83.7 µM -0.0471146087063015 0.47119482432238 no 1793 0.481210942101896 2492 688793 SGTC_2623 humulene 100 µM -0.048875956784243 0.470497458279066 no 1794 0.480509074831625 2536 6187145 An anti-inflammatory. SGTC_677 0929-0063 136 µM -0.0496095480516533 0.470207035927117 no 1795 0.480216768878846 2493 1539583 SGTC_838 0109-0203 71.4 µM -0.0497333905063255 0.470158009344169 no 1796 0.480167423798608 2495 759422 SGTC_2809 7964133 12.99 µM -0.0503980312937533 0.469894899997908 no 1797 0.479902602597315 2513 1253665 SGTC_3103 9120822 49.47 µM -0.0504738491876455 0.469864887029712 no 1798 0.479872394080255 2507 17141819 SGTC_599 1935-0052 86.5 µM -0.0507880663791464 0.46974050409617 no 1799 0.479747200127699 2499 9557311 SGTC_77 0828-0286 12.516 µM -0.052337263197676 0.46912729764631 no 1800 0.479129981126048 2493 745345 SGTC_938 3126-1755 342 µM -0.0552587170355609 0.467971121847328 no 1801 0.477966175459312 2502 1777771 SGTC_1736 st036774 51 µM -0.0560280410324259 0.467666703659261 no 1802 0.477659734363836 2510 1272247 SGTC_423 5-fluorouracil 457 µM -0.0580444464023419 0.466868910929905 no 1803 0.476856612537275 2492 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2341 7987486 176.74 µM -0.060379522729232 0.465945202233237 no 1804 0.475926683695884 2527 1258686 SGTC_1175 0741-0056 27.6 µM -0.0604039465535921 0.465935541625801 no 1805 0.475916957751924 2565 765927 SGTC_2313 7726885 200 µM -0.0609757070936052 0.465709393022946 no 1806 0.475689277989 2568 726423 SGTC_2292 7671323 168.05 µM -0.0617002995580849 0.465422810684808 no 1807 0.475400750706407 2576 937504 SGTC_2580 diallyl disulphide 81.36 µM -0.0619313879249124 0.465331417080589 no 1808 0.47530873575832 2550 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2170 morpholine 200 µM -0.0633397318612322 0.464774468004948 no 1809 0.47474798890735 2574 121171 Reacts with secondary amines. SGTC_3140 9094243 49.47 µM -0.0637013485751753 0.464631472767569 no 1810 0.474604015461106 2522 19291112 SGTC_451 chloral hydrate 100 µM -0.0644261212580478 0.464344887390933 no 1811 0.474315465735921 2605 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1610 st001799 48.1 µM -0.0650821711158067 0.464085491937254 no 1812 0.474054287861092 2525 621897 SGTC_3196 9111891 49.47 µM -0.0656031657893106 0.463879506801884 no 1813 0.473846884305048 2496 18891510 SGTC_1109 tnp00067 928.257 nM -0.0663086772448079 0.463600584896687 no 1814 0.473566037494376 2548 676295 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0665492820299574 0.463505466577812 no 1815 0.473470261626566 2564 23847180 SGTC_294 k038-0071 157 µM -0.0665549523261799 0.46350322496406 no 1816 0.473468004509792 2571 24152826 SGTC_2880 9042983 58.44 µM -0.0666009205822028 0.463485052574427 no 1817 0.47344970642812 2603 6464714 SGTC_1355 1499-0035 1.68 µM -0.066821537056721 0.463397838481261 no 1818 0.473361888817656 2539 1548538 SGTC_1526 st051518 75 µM -0.0686031892811861 0.462693580643822 no 1819 0.472652740085553 2607 673993 SGTC_1173 0443-0020 122 µM -0.0695320781963307 0.462326452356029 no 1820 0.472283049862855 2549 5331295 SGTC_3122 9126309 49.47 µM -0.0695634142623529 0.46231406784168 no 1821 0.472270578778344 2524 17591206 SGTC_2125 5246583 200 µM -0.0696345482730194 0.462285954678869 no 1822 0.472242269063409 2524 835267 SGTC_2158 5657123 3.6195 µM -0.0697931021307878 0.462223292639526 no 1823 0.472179168746663 2510 2858827 SGTC_325 2810-4341 181 µM -0.0709226960969456 0.461776893252856 no 1824 0.471729639992061 2545 774970 SGTC_1571 st070080 73.4 µM -0.0723341477529523 0.461219175468716 no 1825 0.471167994942571 2598 4315245 SGTC_1908 st060353 56.5 µM -0.073331089869 0.460825291929753 no 1826 0.470771326077122 2588 4227716 SGTC_910 3454-3003 490 µM -0.0742844914676881 0.460448646831666 no 1827 0.470392008475279 2522 820824 SGTC_2354 9060492 162 µM -0.0750222862739885 0.460157202391953 no 1828 0.470098489988178 2593 6471895 SGTC_886 0866-0150 153 µM -0.0757565544693346 0.459867172288707 no 1829 0.46980639062982 2561 271463 SGTC_2123 5259487 200 µM -0.0763856132742454 0.459618716036369 no 1830 0.469556157553865 2576 2173474 SGTC_566 0958-0068 16.5 µM -0.0770564948485026 0.45935375863015 no 1831 0.469289301065254 2586 6815365 SGTC_1463 k081-0032 34.1 µM -0.0778406668840734 0.459044081275179 no 1832 0.468977398537051 2543 977755 SGTC_1172 0370-0043 85 µM -0.0783153898300031 0.458856620514856 no 1833 0.468788587873962 2649 376585 SGTC_2556 citropten 84.59 µM -0.0789488326929857 0.458606497966105 no 1834 0.468536660776769 2533 2775 A potential DNA crosslinker. SGTC_1079 idarubicin 2.36 µM -0.0798949995939051 0.458232923112484 no 1835 0.468160383431879 2539 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1326 1431-2094 10.8 µM -0.0807076478467486 0.45791209483164 no 1836 0.467837227279352 2543 616278 SGTC_1342 1486-1464 234 µM -0.08073292919972 0.457902114355516 no 1837 0.467827174283633 2545 3253938 SGTC_552 k242-0005 476 µM -0.0813124811304909 0.45767332834578 no 1838 0.467596724176202 2635 4088318 SGTC_363 0455-0021 3.06 µM -0.0815511555481502 0.457579112445046 no 1839 0.467501822036914 2563 4597466 SGTC_260 nsc-65238 3.989 µM -0.0821793322445489 0.457331153274589 no 1840 0.467252054163055 2559 3246252 SGTC_1154 4088-0362 150 µM -0.0838702734743549 0.456663773577115 no 1841 0.466579787297447 2554 6618304 SGTC_1422 4031-0024 15.5 µM -0.0846519945849856 0.456355285542523 no 1842 0.466269030839162 2552 782427 SGTC_1762 st045503 25.4615 µM -0.085373226102021 0.456070691643441 no 1843 0.465982338955056 2609 4645554 SGTC_592 k241-0073 46.5 µM -0.0873001115641999 0.455310464408322 no 1844 0.465216482672628 2576 4230158 SGTC_607 4491-0986 66.8 µM -0.0878495996972803 0.455093700976994 no 1845 0.464998107632021 2613 698981 YDR232W HEM1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0881097731443231 0.454991071775012 no 1846 0.464894714373283 2736 94937 An inhibitor of serotonin biosynthesis. SGTC_2233 sulbentine 40.3845 µM -0.0885215249768246 0.45482865641511 no 1847 0.464731088517818 2555 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2716 st080858 38.6235 µM -0.0888313803981771 0.454706439035133 no 1848 0.464607959157557 2592 5296050 SGTC_2910 7948405 25.97 µM -0.0891387511649652 0.454585205922463 no 1849 0.464485820489801 2608 2971328 SGTC_2372 9071633 200 µM -0.0904247673261494 0.454078021705549 no 1850 0.463974837915714 2558 21321366 SGTC_1956 st077085 54 µM -0.092102436736845 0.453416488380211 no 1851 0.463308326223815 2608 24208685 SGTC_2659 sanguinarine 24.21 µM -0.092398671295928 0.453299691473771 no 1852 0.463190647533072 2567 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2023 5144124 124 µM -0.0936492891146251 0.452806652890185 no 1853 0.462693877288377 2596 2830192 SGTC_2403 6032726 181.2 µM -0.0939105523466926 0.452703662676355 no 1854 0.462590105662635 2618 2881040 SGTC_3175 9106517 49.47 µM -0.0960100006409816 0.451876174266208 no 1855 0.461756314947376 2644 41468073 SGTC_3082 9117008 49.47 µM -0.0961433461379208 0.451823623740774 no 1856 0.461703362749283 2626 41448529 SGTC_3078 9116413 49.47 µM -0.0979222920255335 0.45112263474593 no 1857 0.460996999288436 2560 17177322 SGTC_1982 st072467 71.9 µM -0.0984474188727543 0.45091573891515 no 1858 0.460788511354311 2549 3163533 SGTC_1215 3852-0577 11.2 µM -0.0988963730914194 0.450738865070364 no 1859 0.460610274322005 2715 2884876 SGTC_2692 st077426 47.7 µM -0.0990795227352846 0.45066671267706 no 1860 0.460537565283476 2612 25238571 SGTC_1314 1222-0010 41.1 µM -0.0993252161021845 0.450569923543048 no 1861 0.460440028927366 2632 3526027 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0996207563036464 0.450453501502335 no 1862 0.460322707325381 2652 6728940 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.100488410707395 0.450111731395834 no 1863 0.459978291590639 2585 688664 SGTC_1344 1488-0097 29.1 µM -0.10049321536777 0.450109838937138 no 1864 0.4599763844623 2668 747966 SGTC_2312 7706453 155.7 µM -0.100969351957407 0.449922303983426 no 1865 0.459787394703418 2606 976098 SGTC_2790 5423970 71.43 µM -0.102730566335627 0.449228715554496 no 1866 0.459088406776936 2698 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1426 4048-4480 71.7 µM -0.103166477152788 0.449057072242324 no 1867 0.458915422633384 2625 14224343 SGTC_2001 4023502 57.655 µM -0.10362566844747 0.448876272370172 no 1868 0.458733208423672 2679 108941 YCR052W RSC6 SGTC_1177 0983-0204 23.6 µM -0.103949881828783 0.448748624473438 no 1869 0.458604560757887 2647 766818 SGTC_3297 9117502 71.43 µM -0.103995214333203 0.448730776777409 no 1870 0.45858657319383 2571 7453720 SGTC_752 1896-0090 130 µM -0.104966768303722 0.448348294783015 no 1871 0.458201089030927 2593 772567 SGTC_2853 9015042 58.44 µM -0.105177787522653 0.448265226934503 no 1872 0.458117367968522 2587 6457456 SGTC_1828 st055811 49 µM -0.106664157149312 0.447680181060505 no 1873 0.457527709393335 2607 5877589 SGTC_2524 avocatin b 10.57 µM -0.10696138415979 0.447563203965179 no 1874 0.457409807464062 2681 6710748 SGTC_1116 jasmonic acid  1.58368 µM -0.107908624810401 0.447190437031026 no 1875 0.457034087732913 2729 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2330 7979373 200 µM -0.108721510607575 0.446870579844723 no 1876 0.456711689995893 2628 1863007 SGTC_1939 st074455 53.6 µM -0.109018186271191 0.44675385144936 no 1877 0.456594032874742 2704 1644229 SGTC_2864 9034755 47.6 µM -0.109048325066564 0.44674199346057 no 1878 0.456582080493017 2582 4930451 SGTC_854 0422-0053 192 µM -0.109227351565652 0.446671557180672 no 1879 0.456511083340838 2609 3596728 SGTC_327 1273-0057 3.96 µM -0.10937898261453 0.446611900696926 no 1880 0.456450951582024 2660 3108138 SGTC_503 tyrphostin 8 294 µM -0.109424530055397 0.446593981119015 no 1881 0.456432889198203 2587 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2080 5212524 12.4 µM -0.109942548667278 0.446390186464354 no 1882 0.456227469049378 2607 260183 SGTC_2923 7992654 58.14 µM -0.11032716894824 0.446238881448734 no 1883 0.456074955539495 2633 2985126 SGTC_1189 1431-2119 7.28 µM -0.111482692098851 0.445784359640562 no 1884 0.455616794872134 2585 3107275 SGTC_1262 0737-0114 49.6 µM -0.112844909529784 0.445248626753346 no 1885 0.455076756527169 2609 765919 SGTC_2970 9090938 41.86 µM -0.114209901893571 0.444711902818446 no 1886 0.454535701348468 2652 17217104 SGTC_1968 st069590 43.6 µM -0.114260243066462 0.44469211027153 no 1887 0.454515748739111 2686 6384066 SGTC_1331 1472-0049 76.2 µM -0.114312451216334 0.444671583834356 no 1888 0.454495056278906 2603 24051409 SGTC_1253 0550-0034 176 µM -0.115470346873224 0.444216377581444 no 1889 0.454036161500588 2687 5969915 SGTC_2032 5185112 25.99 µM -0.115784417632993 0.444092918862314 no 1890 0.453911700187785 2686 5718189 SGTC_2508 celastrol 40.54 µM -0.115903864277668 0.444045966759056 no 1891 0.453864366544494 2585 122724 Celastrol is a natural product and antioxidant. SGTC_2628 lathosterol 100 µM -0.11632331536167 0.443881095095419 no 1892 0.453698154027849 2724 6710616 SGTC_812 4251-0442 148 µM -0.116376862225334 0.443860048380194 no 1893 0.453676936024797 2589 5723007 SGTC_256 clotrimazole 625 nM -0.116468685688626 0.443823957329978 no 1894 0.453640551185259 2595 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_409 arachidonic acid 100 µM -0.117464640249988 0.443432529141924 no 1895 0.453245931506958 2613 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3074 9116018 49.47 µM -0.117766284912384 0.443313988195595 no 1896 0.45312642217326 2592 17027303 SGTC_1395 3486-0190 4.35 µM -0.118674284755391 0.442957191190713 no 1897 0.452766705169822 2644 6748079 SGTC_1040 k898-0338 155 µM -0.119707527410774 0.442551236510917 no 1898 0.45235741861572 2618 20969351 SGTC_896 0964-0007 44.5 µM -0.122577659796871 0.441423896915862 no 1899 0.451220772956455 2595 6756758 SGTC_153 4077-0274 519.67 µM -0.123991613406812 0.440868693635866 no 1900 0.450660957676446 2653 3121976 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.124176164149074 0.440796236458325 no 1901 0.450587897202301 2628 165521 SGTC_790 1575-0012 79.1 µM -0.124570823926945 0.440641294217507 no 1902 0.450431663785689 2621 378741 YLR208W SEC13 SGTC_2379 9035213 200 µM -0.12494638401239 0.440493858896336 no 1903 0.450282998469515 2616 646551 SGTC_88 0180-0332 8.668 µM -0.1253362368742 0.440340821321587 no 1904 0.450128682742777 2607 3101745 SGTC_2897 9048598 12.99 µM -0.126290945385575 0.439966086132379 no 1905 0.449750811704148 2650 6467404 SGTC_1851 st056236 18.9 µM -0.127887608375108 0.439339496007091 no 1906 0.449118958801003 2632 5393171 SGTC_2143 5623677 140.463 µM -0.128331301170245 0.439165401313826 no 1907 0.448943397572462 2612 5375313 SGTC_123 0083-0120 66.675 µM -0.128780596171361 0.438989120436374 no 1908 0.448765629838536 2628 16001701 SGTC_2220 6782180 200 µM -0.129342101391062 0.438768830898196 no 1909 0.448543479554461 2643 833803 SGTC_2681 menadione 3.18 µM -0.129649936352638 0.438648069234787 no 1910 0.448421696568914 2678 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3286 9117135 37.221 µM -0.130373875438631 0.438364095145135 no 1911 0.448135317270338 2681 3438150 SGTC_1725 st036284 20.55 µM -0.130724348889734 0.438226628975431 no 1912 0.44799668500085 2875 707914 SGTC_2932 9016711 44.54 µM -0.13142786338284 0.437950712063001 no 1913 0.447718424020514 2691 7117328 SGTC_1045 1348-1485 165 µM -0.13488441179323 0.436595501684282 no 1914 0.446351632248671 2622 6810614 SGTC_3295 9122362 53.5725 µM -0.135687644197926 0.43628068395047 no 1915 0.446034107939939 2724 4730473 SGTC_2645 abamectin 100 µM -0.135700011015797 0.436275837232948 no 1916 0.446029219506134 2679 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_807 1315-0151 48 µM -0.135821884813257 0.436228073811066 no 1917 0.445981044901328 2669 4011080 SGTC_1283 0922-0125 16.4 µM -0.135863436356093 0.436211789605528 no 1918 0.445964620477165 2742 3360884 SGTC_1817 st052116 64.4 µM -0.136490501549426 0.435966053546998 no 1919 0.445716766473203 2767 4361398 SGTC_3352 9151559 45.5865 µM -0.136925767932258 0.435795494669502 no 1920 0.445544735399771 2711 17159339 SGTC_2991 9074669 71.4286 µM -0.138342915759535 0.435240269009875 no 1921 0.444984704849082 2788 17333109 SGTC_440 fluspirilene 35.1 µM -0.138461960855132 0.435193634018542 no 1922 0.444937665417271 2910 3396 An atypical antipsychotic. SGTC_3071 9117417 49.47 µM -0.1388472595047 0.435042702449241 no 1923 0.444785423981029 2735 45595590 YGL055W OLE1 SGTC_435 c-PAF 6.7 µM -0.139641715371127 0.43473152318498 no 1924 0.444471539707312 2666 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3043 9092303 49.47 µM -0.140221870657274 0.434504308532841 no 1925 0.444242346166696 2676 25236084 SGTC_1295 1013-0063 9.78 µM -0.142040077213586 0.433792358326727 no 1926 0.443524174779417 2687 6826038 SGTC_79 0052-0007 94.094 µM -0.143139732711424 0.433361873272577 no 1927 0.443089912925201 2790 2801472 SGTC_1257 0669-0121 16 µM -0.143344518992924 0.433281713759993 no 1928 0.44300904888585 2764 4307855 SGTC_352 k048-0007 5.11 µM -0.143487066029695 0.433225918180556 no 1929 0.442952762682507 2649 6811911 SGTC_2237 6667747 47.222 µM -0.143600020434272 0.433181706656612 no 1930 0.442908162260107 2701 729940 YDL015C TSC13 SGTC_1338 1486-1223 76 µM -0.145556745920601 0.432415957219862 no 1931 0.442135657986437 2736 3444526 SGTC_1217 1183-1422 255 µM -0.145561257765974 0.432414191836116 no 1932 0.442133876988228 2777 2849664 SGTC_2722 naftopidil 47.16 µM -0.145782076860635 0.43232779193426 no 1933 0.442046712662587 2660 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.14710601095512 0.431809844157063 no 1934 0.441524172721072 2801 61125 An anti-inflammatory. SGTC_3105 9121040 49.47 µM -0.14802336710363 0.431451025959948 no 1935 0.441162163550331 2628 41448907 SGTC_725 1497-0963 19 µM -0.148027885960714 0.431449258576631 no 1936 0.441160380430083 2751 3549977 SGTC_1887 st057648 70.8 µM -0.149066600488513 0.43104304040565 no 1937 0.440750540168555 2824 688672 SGTC_748 act1.228 77.9 µM -0.149373307804169 0.430923107918169 no 1938 0.440629536351713 2672 4421505 YNR035C ARC35 SGTC_467 ro 31-8220 72.8 µM -0.151203394267244 0.430207617648718 no 1939 0.439907636421503 2766 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2413 inermin 26.06 µM -0.152531548687153 0.429688505965735 no 1940 0.439383854648483 2968 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1644 st010134 20.9 µM -0.153633315644943 0.429257970443634 no 1941 0.438949433349958 2695 3818134 SGTC_2017 5132927 60.65 µM -0.155494118190318 0.428531019240335 no 1942 0.438215895275371 2696 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2183 6420625 130.508 µM -0.156559532446947 0.428114907710611 no 1943 0.437795998792554 2675 2897619 SGTC_323 4013-0906 34.3 µM -0.157086122747568 0.427909270437308 no 1944 0.437588487121545 2799 2910086 SGTC_624 k048-0052 28 µM -0.157769808353216 0.427642315544098 no 1945 0.43731909504913 2742 6835531 SGTC_577 r071-0003 38.6 µM -0.157931632110668 0.427579133970113 no 1946 0.437255336016211 2681 4568517 YMR134W ERG29 SGTC_1218 1348-1416 30.7 µM -0.157967187622997 0.42756525212108 no 1947 0.437241327258828 2674 6787668 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.158457798193695 0.427373713435707 no 1948 0.437048036314255 2680 15053 SGTC_1161 k007-0610 110 µM -0.15920769031699 0.42708098204282 no 1949 0.436752622573667 2758 5843850 SGTC_456 gingerol 170 µM -0.159318589711818 0.42703769424093 no 1950 0.436708937672566 2848 442793 A herb. SGTC_1118 chelidonine 707.474 nM -0.159388698455087 0.427010328869562 no 1951 0.436681321206634 2700 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_842 0271-0008 11.1 µM -0.161061960452496 0.426357313202253 no 1952 0.436022300096807 2801 1221709 SGTC_1348 1493-0373 93.8 µM -0.161527630597385 0.426175614249415 no 1953 0.435838925508318 2760 3010129 SGTC_296 1222-0039 74.9 µM -0.161766890983551 0.426082263783598 no 1954 0.435744713374089 2724 5984176 SGTC_464 bw-b 70c 158 µM -0.161869593584681 0.426042194335009 no 1955 0.43570427390205 2835 5353454 SGTC_3032 9089427 49.47 µM -0.162095017433161 0.425954247835227 no 1956 0.435615514910874 2791 17173707 SGTC_967 1306-0166 352 µM -0.162192701361113 0.425916138727259 no 1957 0.435577053585823 2772 4437607 SGTC_2049 5262831 67.185 µM -0.162849295535584 0.425660001784826 no 1958 0.435318547032596 2744 763417 SGTC_2735 sertaconazole 140 nM -0.163333743912872 0.42547103890402 no 1959 0.43512783341613 2684 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2824 7998404 51.95 µM -0.164814982986995 0.424893376373406 no 1960 0.434544805302113 2691 837851 SGTC_759 3486-0358 89.3 µM -0.165188650587171 0.424747676653525 no 1961 0.434397749033384 2716 875103 SGTC_281 1672-3440 14.9 µM -0.165341658017523 0.424688019269215 no 1962 0.434337535829322 2794 6833000 SGTC_1029 k015-0030 64.7 µM -0.166073185830779 0.424402821454314 no 1963 0.434049677855448 2807 2208316 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.166080356998736 0.424400025855467 no 1964 0.434046856156249 2876 1273210 SGTC_2882 9058044 58.44 µM -0.166503896616423 0.424234920468987 no 1965 0.433880208459831 2786 18076804 SGTC_1106 tegaserod maleate 11.7 µM -0.1676995005632 0.42376891865957 no 1966 0.43340984455931 2752 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1936 st074407 74.3 µM -0.170087273800747 0.42283857335384 no 1967 0.432470750861649 2698 809813 SGTC_622 1348-1566 26.3 µM -0.170962914564065 0.422497505993918 no 1968 0.432126463056247 2793 7340407 SGTC_774 k060-0086 136 µM -0.171007175372098 0.422480267682631 no 1969 0.43210906178759 2695 5911235 SGTC_1997 st073024 93.8 µM -0.171112984689486 0.422439058599562 no 1970 0.432067463072794 2709 686268 SGTC_990 3985-0011 41.3 µM -0.171152079058097 0.422423832904886 no 1971 0.432052093392967 2787 5399565 YGL099W LSG1 SGTC_1188 1403-0014 4.57 µM -0.171249279067426 0.422385977887006 no 1972 0.432013880329314 2737 9614867 SGTC_1789 tunicamycin 25 nM -0.171781250566403 0.422178811698491 no 1973 0.431804753140273 2812 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2272 7805186 180 µM -0.173852731026728 0.421372318658955 no 1974 0.430990600989424 2699 2956062 YPR165W RHO1 SGTC_2007 4011539 71.82 µM -0.174161587865068 0.421252099063409 no 1975 0.4308692362872 2702 45595301 SGTC_2926 9010726 65.15 µM -0.174641301214244 0.421065389751217 no 1976 0.430680746794844 2822 2994293 SGTC_112 phenothiazine 287.218 µM -0.174835292482577 0.420989891415693 no 1977 0.430604528015643 2715 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2572 astragaloside iv 100 µM -0.175318579722049 0.420801816302163 no 1978 0.430414656679197 2902 45006101 An anti-inflammatory agent. SGTC_1322 1348-1070 12 µM -0.175476120872654 0.42074051180149 no 1979 0.43035276621919 2714 6758089 SGTC_71 0417-1750 47.813 µM -0.176259089550239 0.420435861194575 no 1980 0.430045200302693 2921 6811472 SGTC_3107 9121808 49.47 µM -0.17720564159984 0.420067624465632 no 1981 0.429673432219753 2703 662681 SGTC_1132 3456-3614 2.5 µM -0.179404633742797 0.419212422101952 no 1982 0.428809996608017 3003 3125502 SGTC_1802 st050112 57.9 µM -0.183650163429598 0.417562390706451 no 1983 0.42714395380872 2703 4662563 SGTC_553 k007-0256 45.7 µM -0.186510377003165 0.416451580370538 no 1984 0.426022270980874 2777 6287000 SGTC_3316 9136639 10.545 µM -0.186681482653454 0.416385149769417 no 1985 0.425955187780289 2825 4903665 SGTC_3345 9148410 3.559 µM -0.187010445297687 0.416257438978838 no 1986 0.42582622163165 2847 4903596 SGTC_1811 st050069 61.5 µM -0.187541535292454 0.41605127641079 no 1987 0.425618030450908 2735 3877702 SGTC_2056 5235370 200 µM -0.187964954819559 0.415886926732382 no 1988 0.425452061737613 2776 5511916 SGTC_680 0417-1641 114 µM -0.187975514774063 0.415882828089164 no 1989 0.42544792269697 2721 2835990 SGTC_3193 9111931 49.47 µM -0.189239077053505 0.415392466865794 no 1990 0.424952720942942 2747 17087244 SGTC_34 0469-0683 81.75 µM -0.189648552614577 0.415233586474395 no 1991 0.424792269044069 2822 3690923 SGTC_3000 9075062 71.4286 µM -0.189802629014198 0.415173806961226 no 1992 0.424731897845473 2785 17057871 SGTC_2939 9044578 71.43 µM -0.190232357170376 0.415007088757471 no 1993 0.424563528348781 2732 2653634 SGTC_1765 st044815 90.4 µM -0.191381848404547 0.414561205118884 no 1994 0.424113220049856 2829 645695 SGTC_755 1995-0008 37.3 µM -0.191619577508799 0.414469004545707 no 1995 0.424020103027135 2734 689533 SGTC_1680 diphenhydramine 100 µM -0.192453226388081 0.414145720425812 no 1996 0.42369360145797 2808 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.193122285960568 0.413886305129756 no 1997 0.423431599757888 2744 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2264 7948757 110.76 µM -0.19407560512556 0.413516738445849 no 1998 0.423058341370415 2729 2971411 SGTC_2075 5212009 200 µM -0.19500851106101 0.413155159371847 no 1999 0.422693142336984 2864 780898 SGTC_1337 1486-1011 40.3 µM -0.195043844197758 0.413141466271927 no 2000 0.422679311991814 2749 X1337 SGTC_322 k048-0136 19.3 µM -0.195223215404608 0.413071953896654 no 2001 0.422609102721499 2837 6823282 SGTC_1282 0886-0010 32.4 µM -0.196311609972036 0.412650222911056 no 2002 0.42218313737575 2890 2836211 YNL267W PIK1 SGTC_3180 9109287 49.47 µM -0.19703597713951 0.412369601058901 no 2003 0.421899691963152 2878 18891271 SGTC_3265 9137266 49.47 µM -0.198836428173265 0.411672295651993 no 2004 0.421195349667321 2723 17224265 SGTC_2885 9057732 51.95 µM -0.199034377896671 0.411595647719958 no 2005 0.421117926435042 2906 6471414 SGTC_1547 harmine 94.2 µM -0.199643416362203 0.411359843659748 no 2006 0.420879734956594 2780 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1778 st046819 58.9 µM -0.202249684581262 0.410351126179492 no 2007 0.419860766463637 2775 671715 SGTC_3311 9131146 2.8755 µM -0.203204694469356 0.40998165181183 no 2008 0.41948752186389 2825 4900406 YPR165W RHO1 SGTC_2799 7812892 81.82 µM -0.205298294497046 0.409171959549971 no 2009 0.418669538237532 2940 20205235 SGTC_413 propylparaben 100 µM -0.20577140349323 0.408989039887872 no 2010 0.418484739935941 2754 7175 A pharmaceutical preservative. SGTC_501 nsc-95397 161 µM -0.206247031364154 0.408805166322141 no 2011 0.418298975885271 2948 262093 SGTC_567 1080-0542 68.4 µM -0.206250377240338 0.408803872906777 no 2012 0.418297669164462 2769 5950415 SGTC_2159 5658611 73.75 µM -0.207123848601057 0.408466249093509 no 2013 0.417956568718357 2775 793844 SGTC_1758 st042942 75.2445 µM -0.20753092522093 0.408308924525617 no 2014 0.41779762175855 2752 669317 SGTC_3350 9150499 3.57 µM -0.207560460849408 0.408297510345073 no 2015 0.417786089812067 2753 4910996 YPR165W RHO1 SGTC_1458 k015-0034 6.33 µM -0.209465997080894 0.407561271889103 no 2016 0.417042238494377 2831 3598957 SGTC_155 k072-0202 43.6 µM -0.209742390572768 0.407454509297159 no 2017 0.416934369222292 2731 5857737 SGTC_306 1672-3436 11.6 µM -0.210180103922688 0.407285447703836 no 2018 0.41676355375411 2872 6797378 SGTC_3024 9090631 49.47 µM -0.211486172546924 0.406781096941168 no 2019 0.416253960459207 2820 25236383 SGTC_1732 st034308 51.822 µM -0.211610451969954 0.406733113306349 no 2020 0.416205477248647 2719 830119 SGTC_356 1634-0012 32.5 µM -0.212385893304115 0.406433751116605 no 2021 0.41590299513086 2828 735457 SGTC_550 4123-0385 25.7 µM -0.213043752935413 0.406179824672283 no 2022 0.415646418023259 2784 5731123 SGTC_898 1000-0849 28.3 µM -0.213400213876016 0.40604225122011 no 2023 0.415507406848345 2768 6751807 SGTC_3060 1327-0027 12.5 µM -0.213486056422521 0.406009122659578 no 2024 0.415473931903493 2874 16000455 YPR107C YTH1 SGTC_2695 st077686 51.995 µM -0.214052503222548 0.405790535041328 no 2025 0.415253057116188 2836 2876092 SGTC_119 0121-0043 24.815 µM -0.216193563493348 0.404964581624216 no 2026 0.414418435252975 2777 1092378 SGTC_1661 st013063 9.66 µM -0.216234104806606 0.4049489461371 no 2027 0.41440263527114 2796 721395 SGTC_1861 st057647 17.4 µM -0.21716990601168 0.404588079783856 no 2028 0.414037968267409 2973 688668 SGTC_875 0709-0210 25.7 µM -0.217170096662389 0.404588006272838 no 2029 0.414037893981367 2767 6251364 SGTC_1204 4049-0315 18.3 µM -0.218609939723212 0.404032928447008 no 2030 0.413476954650197 3050 588402 SGTC_639 0833-0042 114 µM -0.218775022448629 0.403969299278107 no 2031 0.413412652377264 2804 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_568 1193-0097 7.48 µM -0.219758832882313 0.403590154018582 no 2032 0.413029491224371 2874 3646150 SGTC_808 0711-0032 135 µM -0.221094229479412 0.403075657900327 no 2033 0.412509531647653 2762 4252555 SGTC_129 0088-0017 176.636 µM -0.222063052792076 0.402702498578735 no 2034 0.412132399693247 2883 182446 SGTC_1728 st035614 33.7865 µM -0.222216190308117 0.402643523076123 no 2035 0.412072795568699 2909 15945546 SGTC_2797 7859098 81.82 µM -0.222280573702471 0.402618728748443 no 2036 0.412047736894495 2822 972681 SGTC_702 1488-0190 94 µM -0.223240344892759 0.402249163144295 no 2037 0.411674226724984 2881 949357 SGTC_2927 9011802 47.9 µM -0.224155029675458 0.401897039623618 no 2038 0.411318337110117 2910 43912568 SGTC_2185 6113692 200 µM -0.224620956838843 0.401717703598678 no 2039 0.411137080132063 2926 874150 SGTC_1065 prochlorperazine maleate 2.48 µM -0.225322774829441 0.40144761193482 no 2040 0.410864091712566 2815 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2976 9009005 19.48 µM -0.225675995687091 0.401311694194159 no 2041 0.410726714571818 3025 2993148 SGTC_2321 7390090 138.78 µM -0.227826858232065 0.400484310614229 no 2042 0.409890422932164 2895 649046 SGTC_63 0099-0242 26.702 µM -0.22984485454721 0.399708443119286 no 2043 0.409106164376527 2961 3898502 YLR359W ADE13 SGTC_569 4130-2812 160 µM -0.230663907243346 0.399393651255983 no 2044 0.408787957627978 2798 743552 SGTC_572 0960-0087 17.7 µM -0.231390034377262 0.399114628762005 no 2045 0.408505903264554 2833 6796365 SGTC_1239 0337-0584 35.4 µM -0.232612309029371 0.398645072475901 no 2046 0.40803123412797 2982 914301 YML130C ERO1 SGTC_181 1447-1644 8.07 µM -0.238965046002191 0.396206944155847 no 2047 0.405566343422664 2920 534600 SGTC_2453 5731132 22.18 µM -0.239264783029841 0.396092006958325 no 2048 0.405450135734221 2971 1362040 SGTC_1840 st055363 71 µM -0.240490086827108 0.395622245845607 no 2049 0.404975173684297 2843 676033 SGTC_1067 clotrimazole 1.36 µM -0.240591992751887 0.395583183626536 no 2050 0.40493567838925 2835 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_266 formosanin C 406 nM -0.240752889319659 0.395521511458133 no 2051 0.404873322284634 2944 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2115 tiliquinol 12.7705 µM -0.241300752326711 0.395311533447009 no 2052 0.404661013921825 2934 71208 A bioactive hydroxyquinoline. SGTC_1942 st076330 65.2 µM -0.24196073172568 0.395058625243719 no 2053 0.404405295387886 2996 24208414 SGTC_1856 st057054 55.7 µM -0.243583876042235 0.394436814517287 no 2054 0.403776558635824 3090 1266018 SGTC_2805 7950783 58.44 µM -0.244418346192674 0.394117241711512 no 2055 0.403453417189571 2965 1178958 YDL195W SEC31 SGTC_384 k007-0144 5.16 µM -0.244940550896256 0.393917291864638 no 2056 0.403251231384175 2900 6824886 SGTC_1409 3909-8004 61.9 µM -0.24600954343369 0.393508066658946 no 2057 0.402837422451187 2872 2119279 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.246178256545391 0.393443491667822 no 2058 0.402772123232554 2958 16725076 SGTC_2634 4'-methoxyflavone 100 µM -0.246736684669961 0.393229774060444 no 2059 0.402556006923909 2916 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1973 st070275 50.2 µM -0.24755569775677 0.392916385454799 no 2060 0.402239095953694 2810 17118334 SGTC_1881 5652484 16 µM -0.247560355665672 0.392914603342629 no 2061 0.40223729379433 2983 2255129 SGTC_2038 4100038 30.985 µM -0.247689232852124 0.392865295925872 no 2062 0.402187431636515 2945 3596803 SGTC_2839 9003951 25.97 µM -0.248425377954786 0.39258368546776 no 2063 0.401902650061813 2883 2990634 SGTC_632 0781-2353 4.65 µM -0.248664334515327 0.392492285317731 no 2064 0.401810219657813 2931 6811515 YHR007C ERG11 SGTC_2746 daunorubicin 9.88 µM -0.249373464319324 0.392221080272758 no 2065 0.401535954647146 2838 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2757 clomiphene 4.22 µM -0.249921748343983 0.392011426196627 no 2066 0.401323932033478 3067 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1256 0570-0116 285 µM -0.24995226553958 0.391999757883325 no 2067 0.401312131821118 2860 410638 SGTC_1434 4073-0095 163 µM -0.250754816506878 0.391692935743523 no 2068 0.40100183840373 2869 24133745 SGTC_2860 9025725 38.96 µM -0.25082648336978 0.391665540158461 no 2069 0.400974132598421 2810 40546248 SGTC_245 methotrexate 289.6 µM -0.251100048658409 0.391560971229895 no 2070 0.400868379143073 2927 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_288 1315-0019 35.1 µM -0.252442739699763 0.39104784820141 no 2071 0.400349434042712 2929 6811474 SGTC_2718 lomofungin 53.02 µM -0.252810250801926 0.390907433111434 no 2072 0.400207422986298 3011 5351222 A RNA synthesis inhibitor. SGTC_1401 3807-4679 7.6 µM -0.253259222316199 0.390735913715168 no 2073 0.40003395247641 2834 3291456 SGTC_1484 3473-2379 286 µM -0.254357314703177 0.390316502028112 no 2074 0.399609762309781 2850 671917 SGTC_496 calpeptin 138 µM -0.256698973800845 0.389422542166597 no 2075 0.398705581898752 2921 73364 A calpain inhibitor. SGTC_2359 9039622 200 µM -0.259091140757631 0.388509904132107 no 2076 0.397782460063893 2843 6463596 SGTC_1724 st037281 8.293 µM -0.264131676436155 0.386588903368918 no 2077 0.395839228041208 2849 574124 YDL195W SEC31 SGTC_3310 9130229 44.1445 µM -0.265582980990026 0.386036308652467 no 2078 0.395280197109201 3034 7761258 SGTC_2191 5911152 200 µM -0.265621601435783 0.386021606790433 no 2079 0.395265323759553 2928 2875902 SGTC_2040 5100729 123 µM -0.267663074690123 0.385244701195723 no 2080 0.394479337550174 2876 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1799 st045822 46.1415 µM -0.267677907441312 0.38523905810632 no 2081 0.394473628370349 3024 3674992 SGTC_2941 9056145 11.23 µM -0.26926812409712 0.384634204668021 no 2082 0.393861679926816 2864 2119517 SGTC_1656 st012921 11 µM -0.270215992784384 0.384273807580786 no 2083 0.393497044865956 2992 6732821 SGTC_462 ag-879 158 µM -0.270788230732259 0.384056280601129 no 2084 0.393276956164048 2996 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_274 sirtinol 40.1 µM -0.271915306910503 0.383627947719838 no 2085 0.392843570664059 2913 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1795 st049545 62.3 µM -0.274246509990983 0.382742451336732 no 2086 0.391947593950938 2984 5291882 SGTC_3320 9137005 35.139 µM -0.274842607759878 0.382516124602204 no 2087 0.391718580946224 2928 4908713 SGTC_1806 st050005 60.3 µM -0.275777097453422 0.382161397810486 no 2088 0.391359637704951 2899 5194765 SGTC_864 0469-0573 172 µM -0.276009075682772 0.382073355548187 no 2089 0.391270547758348 2886 689425 SGTC_216 k038-0035 28.382 µM -0.277222149700439 0.381613059254719 no 2090 0.390804766445148 2988 4444231 YPR107C YTH1 SGTC_2831 7999036 19.48 µM -0.280060712751819 0.380536632405647 no 2091 0.389715462848563 3173 2988270 SGTC_1625 st003711 30.1 µM -0.281984279417943 0.379807711126019 no 2092 0.388977782289942 3103 24207034 YER133W GLC7 SGTC_96 0929-0093 37.281 µM -0.281992986624984 0.379804412563213 no 2093 0.388974444016464 2899 6991579 SGTC_824 1304-0008 100 µM -0.282008149185224 0.379798668531256 no 2094 0.38896863083181 2917 768245 SGTC_2338 7999974 200 µM -0.282962475651779 0.37943719449655 no 2095 0.388602801002863 2962 315925 SGTC_2753 fluvastatin 17.09 µM -0.283357647238078 0.379287544610407 no 2096 0.388451345523392 2989 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_617 3770-0098 35 µM -0.285686219150855 0.378406091788419 no 2097 0.387559230263281 2914 5962639 SGTC_1708 st033234 31.827 µM -0.285723009256091 0.378392170400022 no 2098 0.387545140101145 3035 674664 SGTC_1306 1185-0270 9.02 µM -0.286064412947616 0.378262990657342 no 2099 0.387414393712989 3021 1548076 SGTC_66 0109-0187 42.4 µM -0.287881836343154 0.377575546442563 no 2100 0.386718595556223 2815 759417 SGTC_2342 7990637 118.86 µM -0.289236723873653 0.377063309467359 no 2101 0.386200115328073 3032 2033102 YER133W GLC7 SGTC_935 2996-0153 430 µM -0.289258901558669 0.377054926634235 no 2102 0.386191630192114 3073 23738523 SGTC_2417 cerulenin 830 nM -0.290776035690458 0.37648161039529 no 2103 0.385611307271983 3011 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1965 Pectolinarigenin 58.4 µM -0.291703212774322 0.376131369528535 no 2104 0.385256776285563 2923 5320438 An anti-inflammatory. SGTC_1429 4049-0205 9.46 µM -0.291879777017408 0.376064683990349 no 2105 0.385189273077676 2929 22774478 SGTC_1063 disulfiram 1.84 µM -0.292725645642965 0.375745264071413 no 2106 0.384865932864453 2913 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_350 k064-0020 19.8 µM -0.30046326359074 0.372827334015347 no 2107 0.381911907005569 3132 2790705 SGTC_3341 9147222 25.867 µM -0.301363039019998 0.372488489517817 no 2108 0.381568837768911 3050 1939759 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.301528828034833 0.372426066146515 no 2109 0.381505635346776 2961 66535 A nucleotide analog. SGTC_710 3448-4187 58 µM -0.30355555105296 0.371663229752433 no 2110 0.380733259782475 2982 3946412 SGTC_2507 purpurin 79.67 µM -0.303650453910459 0.371627521675638 no 2111 0.380697104325507 2918 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2540 epiandrosterone 100 µM -0.303807595999172 0.371568397941929 no 2112 0.380637239672836 2959 441302 A steroid. SGTC_1230 0170-0365 3.77 µM -0.305338886687999 0.370992418144053 no 2113 0.380054030916591 3058 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1238 0333-0287 48.8 µM -0.306427002831888 0.370583309553839 no 2114 0.379639775635102 2952 7226 SGTC_125 0133-0007 11.75 µM -0.306433004404339 0.370581053495172 no 2115 0.379637491166807 3082 26541 SGTC_1374 2889-5571 141 µM -0.306513994978023 0.370550608661818 no 2116 0.379606662924213 3008 2853281 SGTC_3301 9125354 19.7965 µM -0.306803516901165 0.370441782296741 no 2117 0.379496465591862 2913 41905162 SGTC_3232 9132874 49.47 µM -0.307179523514746 0.370300463284622 no 2118 0.37935336521827 2947 3784940 SGTC_1649 st011737 51.3 µM -0.308270415235426 0.369890559672427 no 2119 0.378938287893902 3002 1761035 SGTC_2450 5739737 12.93 µM -0.308683623013016 0.369735335015728 no 2120 0.378781101396081 3042 2262825 SGTC_2380 9035439 200 µM -0.308939626391204 0.369639176038595 no 2121 0.378683726367764 3093 6462575 SGTC_397 arbidol 50 µM -0.309973899967805 0.369250769342396 no 2122 0.378290402138228 3097 131410 A RNA synthesis inhibitor. SGTC_857 0438-0306 1.35 µM -0.309992695076448 0.369243712340586 no 2123 0.37828325570558 3048 4686136 SGTC_1386 3228-0095 33.8 µM -0.312462871682938 0.368316619108042 no 2124 0.377344387795683 3089 870181 SGTC_481 bay k-8644 50 µM -0.313329703536417 0.367991465832388 no 2125 0.377015092661674 2963 2303 A calcium channel antagonist. SGTC_887 0885-0007 9.62 µM -0.313719713534212 0.36784520182041 no 2126 0.376866963447172 3084 5719458 SGTC_3328 9140624 29.0385 µM -0.313968597493555 0.36775187380033 no 2127 0.376772444610113 3104 4904392 SGTC_2591 skatole 100 µM -0.314725088071001 0.367468248319821 no 2128 0.376485197012235 3078 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2314 7727897 200 µM -0.315600375348358 0.36714017346487 no 2129 0.376152926373495 2954 900724 SGTC_509 pifithrin 175 µM -0.315600896718242 0.367139978074081 no 2130 0.376152728481911 3055 4817 A p53 inhibitor. SGTC_1684 st024538 14.6195 µM -0.318291713296302 0.36613201566772 no 2131 0.375131834778539 2972 6732859 SGTC_1123 mangostin 811.285 nM -0.318700245659561 0.365979062640229 no 2132 0.374976914174782 3027 5281650 An antioxidant. SGTC_873 0591-4978 488 µM -0.319125048421304 0.365820040620904 no 2133 0.374815845022023 3170 3305145 SGTC_448 monastrol 171 µM -0.319756598342849 0.365583666829045 no 2134 0.374576425526907 3014 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3113 9123498 49.47 µM -0.319885048591707 0.365535597264227 no 2135 0.374527736170712 3007 8897275 SGTC_2157 5649910 96.377 µM -0.322422419196928 0.364586478165271 no 2136 0.373566351130576 2971 2858091 SGTC_1629 st005085 44.9 µM -0.323021065999361 0.364362671363468 no 2137 0.373339644099778 2957 24207091 SGTC_660 4031-1742 102 µM -0.329417907003265 0.361974084203864 no 2138 0.370919917298073 2983 6738706 SGTC_2245 6637752 200 µM -0.330261204961859 0.361659594213308 no 2139 0.370601301902181 3107 681890 SGTC_2876 9059903 25.97 µM -0.330872208482253 0.36143179183103 no 2140 0.370370507564707 2958 6916095 SGTC_2766 oltipraz 83.91 µM -0.333291910381637 0.360530129785202 no 2141 0.369456972616894 3137 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_454 lyso-paf C-16 6.67 µM -0.333393074268237 0.360492449572273 no 2142 0.369418795179415 3063 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3213 9129884 49.47 µM -0.334449132173665 0.360099183761805 no 2143 0.36902033479905 3076 17190742 SGTC_1687 st020778 55.3625 µM -0.33456004178948 0.360057890668824 no 2144 0.368978495736887 3016 4259299 SGTC_480 am 92016 50 µM -0.335795001854804 0.359598209386365 no 2145 0.368512729748296 3061 2129 K+ channel blocker. SGTC_836 0330-0104 1.35 µM -0.336033521263152 0.359509450211129 no 2146 0.368422794229757 3008 46494820 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.337098761640278 0.35911313957801 no 2147 0.368021225460331 3062 688801 SGTC_319 1348-1596 45.5 µM -0.337352832781139 0.35901863765393 no 2148 0.367925468324092 3185 5380505 SGTC_1376 2910-0861 41.3 µM -0.33887057603999 0.358454291946097 no 2149 0.367353615629134 2985 1112859 SGTC_277 nystatin 15.5 µM -0.339469768463859 0.358231577955758 no 2150 0.367127933829923 2948 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1963 st076565 50.3 µM -0.342674048138082 0.357041398580281 no 2151 0.36592184424297 3015 4914280 SGTC_3258 9138477 49.47 µM -0.344206094884194 0.356472834258141 no 2152 0.365345649498187 3044 4970355 SGTC_2802 7925815 54.55 µM -0.344795152353389 0.356254311451499 no 2153 0.365124188860907 2983 1262923 SGTC_1439 4092-1168 46 µM -0.345344769095397 0.356050462541813 no 2154 0.364917596822552 3076 2886240 SGTC_2532 xanthone 78.9 µM -0.34727500924916 0.355334876603078 no 2155 0.364192361803408 3121 7020 An insecticide. SGTC_870 0573-2213 57.6 µM -0.347943406443383 0.355087204554225 no 2156 0.36394134297028 3011 3916321 SGTC_1952 st077036 64.1 µM -0.348058918033881 0.35504440837245 no 2157 0.363897968113454 2986 2937007 SGTC_705 1124-0212 310 µM -0.348355973730366 0.354934359854133 no 2158 0.36378643105457 3176 9554485 SGTC_57 miconazole 162.5 nM -0.348396937856667 0.354919185058754 no 2159 0.363771050944747 3050 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1387 3342-1166 1.8 µM -0.350152794867578 0.354268960127243 no 2160 0.363112015558541 3072 3418228 SGTC_921 1561-0023 372 µM -0.351370379418122 0.353818316195653 no 2161 0.362655250636075 2996 24050882 SGTC_1373 2887-0003 58.5 µM -0.352881765670558 0.353259217267753 no 2162 0.362088540723617 3085 776948 SGTC_1281 0884-0031 11.8 µM -0.353919503503799 0.352875515746768 no 2163 0.361699605081323 3052 1548255 SGTC_3070 9117005 49.47 µM -0.354434343823596 0.352685210041341 no 2164 0.361506700126712 3096 8779016 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.355693106151992 0.352220076128357 no 2165 0.361035204171803 3036 4620898 SGTC_289 k017-0060 526 µM -0.356815075637039 0.351805675702857 no 2166 0.360615124738147 3047 5512909 SGTC_1323 1348-1351 11.2 µM -0.360447690247726 0.350465175824465 no 2167 0.359256184144819 3048 6989654 SGTC_587 k089-0003 57 µM -0.360660255697638 0.350386792816401 no 2168 0.359176719530317 3083 9659696 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.36181012641314 0.349962891227541 no 2169 0.358746962165741 3083 97141 SGTC_3338 9144300 39.5675 µM -0.362237327824838 0.34980545037051 no 2170 0.358587343686527 3096 4901274 SGTC_1877 wortmannin 25 µM -0.364204293712979 0.349080878071657 no 2171 0.357852730470257 3181 312145 A covalent inhibitor of PI 3-kinase. SGTC_1418 3966-3099 2.4 µM -0.365190197934722 0.348717906693655 no 2172 0.357484717345432 3138 740335 SGTC_328 k915-0120 63.5 µM -0.366248853225807 0.348328305343752 no 2173 0.357089695594478 3155 6624543 SGTC_209 4077-0173 175.592 µM -0.366449061956878 0.348254643442405 no 2174 0.357015007838932 3119 15993494 SGTC_515 4092-1064 102 µM -0.367573900665909 0.347840893063372 no 2175 0.356595489331789 3256 717353 SGTC_709 3807-1509 243 µM -0.367765642866925 0.347770382422208 no 2176 0.356523994676072 3102 1886677 YPL242C IQG1 SGTC_2761 levamisole 97.89 µM -0.369007055310882 0.347313997010865 no 2177 0.356061232974454 3206 26879 An alkaline phosphatase inhibitor. SGTC_1597 7-benzyloxygramine 47.5 µM -0.369697181298913 0.347060378901437 no 2178 0.355804066116161 3052 260807 SGTC_2067 5224629 34.075 µM -0.369733157655368 0.347047159634092 no 2179 0.355790661772998 3196 2835000 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.369921011415124 0.346978137072198 no 2180 0.355720672693984 3029 6708514 SGTC_1102 cgs 12066b 26.1 µM -0.370400568364767 0.346801957881381 no 2181 0.35554202519061 3094 6438352 A 5-HT1B full agonist. SGTC_531 3788-1495 174 µM -0.375942920982182 0.344768225379077 no 2182 0.35347966539214 3005 2896655 SGTC_403 arphamenine a 50 µM -0.376495131467213 0.344565839445606 no 2183 0.353274417112791 3061 5487158 An arginine aminopeptidase inhibitor. SGTC_1941 st076221 61.8 µM -0.377726815668341 0.344114585760018 no 2184 0.352816772535668 3170 2828568 SGTC_2440 5628896 157.78 µM -0.378533718303622 0.34381908008347 no 2185 0.352517075163846 3056 5522048 SGTC_641 4092-0595 30 µM -0.379031920734604 0.343636674899071 no 2186 0.352332079991723 3149 786260 SGTC_1046 2001-0062 216 µM -0.379616824682047 0.343422572434693 no 2187 0.352114934932461 3034 739778 SGTC_2459 5811157 9.22 µM -0.381967848482045 0.342562494059085 no 2188 0.351242606461445 3094 2870684 YBR192W RIM2 SGTC_1508 1080-0625 72.9 µM -0.382665077884326 0.3423075822457 no 2189 0.350984055454041 3039 767111 SGTC_2549 cedrol 20.94 µM -0.384690061620237 0.341567642017878 no 2190 0.350233529652075 3212 6708665 A sedative which affects the nervous system. SGTC_3349 9149703 23.001 µM -0.385580554687953 0.341242443381029 no 2191 0.349903668388105 3068 4910494 SGTC_579 4491-1009 110 µM -0.386278329737823 0.340987705672871 no 2192 0.349645273896324 3220 1271041 SGTC_1735 st034310 56.75 µM -0.386739354626463 0.340819438427153 no 2193 0.34947458903387 3254 871153 SGTC_1630 st005209 31.3 µM -0.386856597375268 0.340776651612033 no 2194 0.349431187200198 3203 3367314 SGTC_132 0417-1715 25.805 µM -0.387733332523941 0.34045675900754 no 2195 0.349106692989778 3248 6769098 SGTC_596 1155-0152 116 µM -0.388236564902511 0.34027319743328 no 2196 0.348920488151975 3122 280313 SGTC_2278 7948257 134.34 µM -0.389272233930461 0.33989554070991 no 2197 0.348537386892989 3206 1247028 SGTC_236 1509-0011 5.31 µM -0.39014775467547 0.339576407324971 no 2198 0.348213646044188 3234 3107280 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.391044332416039 0.3392497176838 no 2199 0.347882233548937 3325 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2553 4-methylesculetin 85.09 µM -0.392546521168896 0.338702629969096 no 2200 0.347327222483603 3155 5319502 SGTC_1779 st039427 55 µM -0.39271193988497 0.338642406280723 no 2201 0.347266125497229 3303 1124498 SGTC_521 r062-0005 13.8 µM -0.392911250760486 0.338569849016166 no 2202 0.347192515799109 3078 2832033 SGTC_1272 0839-0021 27 µM -0.392988521998123 0.338541720754677 no 2203 0.347163979456367 3169 5027250 SGTC_638 3970-0837 4.09 µM -0.393056875677125 0.338516839411991 no 2204 0.34713873709895 3103 4118451 YLR208W SEC13 SGTC_1193 1488-0126 41.5 µM -0.393358031516631 0.338407224423046 no 2205 0.347027531216203 3111 1384710 SGTC_1312 1218-2183 165 µM -0.393768158019363 0.338257968208683 no 2206 0.34687610762315 3159 6744073 SGTC_2698 st077697 67.5 µM -0.395592740819371 0.337594261087117 no 2207 0.34620274657718 3119 3154499 SGTC_3099 9120367 49.47 µM -0.396907633632092 0.337116270777977 no 2208 0.345717787393188 3077 24824940 SGTC_1240 0356-0016 42.1 µM -0.398278669108331 0.336618151373858 no 2209 0.345212391130963 3128 4305613 SGTC_2090 5301565 104.445 µM -0.401638968751955 0.335398513260504 no 2210 0.343974873215123 3111 2056344 SGTC_793 0488-0545 106 µM -0.401850457714355 0.335321810075274 no 2211 0.34389704259973 3078 292548 SGTC_796 1234-0020 70.7 µM -0.403133409733819 0.334856654029985 no 2212 0.343425041885993 3101 46495034 SGTC_3220 9131269 49.47 µM -0.404233306742462 0.33445806927689 no 2213 0.343020581772928 3201 17722206 SGTC_2696 st077691 74.316 µM -0.404352055036144 0.33441504797868 no 2214 0.342976925750038 3260 757133 SGTC_2977 9011197 71.43 µM -0.404424155670028 0.334388927713791 no 2215 0.342950420059884 3291 2704722 SGTC_1408 3909-7976 48.8 µM -0.40456148100242 0.334339180382106 no 2216 0.342899938554166 3158 24152374 SGTC_614 0462-0418 107 µM -0.404590752186369 0.334328577009658 no 2217 0.342889178677431 3136 5188303 SGTC_654 1124-0271 80.9 µM -0.405515267919121 0.333993742843083 no 2218 0.342549398954197 3133 5403748 SGTC_1279 0874-0590 65.2 µM -0.406520610931126 0.333629785192263 no 2219 0.342180057998795 3168 3523074 SGTC_2296 7971656 126.45 µM -0.406786952380791 0.333533389577464 no 2220 0.342082235270447 3180 666570 SGTC_2182 6325192 200 µM -0.407387861259768 0.333315946039816 no 2221 0.341861570497988 3225 736248 SGTC_173 1273-0061 2.693 µM -0.408841702173088 0.33279009421241 no 2222 0.34132791697509 3217 2847414 YPL266W DIM1 SGTC_1910 st062352 60.4 µM -0.410332172812658 0.332251334723581 no 2223 0.340781147174142 3046 2245730 SGTC_1033 k072-0102 21.3 µM -0.413983004095801 0.330933136606496 no 2224 0.339443276959624 3279 5965931 SGTC_2618 avocadyne 43.43 µM -0.415259174301122 0.330472845361521 no 2225 0.338976092143357 3123 3015189 SGTC_1937 st074714 47.2 µM -0.415576431299257 0.330358456322941 no 2226 0.338859987991051 3107 17250970 SGTC_1773 st048542 73.5835 µM -0.415769651531712 0.330288797298497 no 2227 0.338789284138286 3125 3237138 SGTC_3198 9112019 49.47 µM -0.416149746782143 0.330151783967817 no 2228 0.338650214874937 3160 45595555 SGTC_996 3970-0799 1.8 µM -0.416562685245656 0.330002957421246 no 2229 0.338499153864972 3176 6615648 YGL040C HEM2 SGTC_2636 apigenin dimethyl ether 100 µM -0.418191320316221 0.32941624590091 no 2230 0.33790362065391 3280 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1325 1431-0015 227 µM -0.420268146041169 0.328668683844392 no 2231 0.337144788624843 3134 1103340 SGTC_1087 pterostilbene 9.05 µM -0.420860725885389 0.32845550776506 no 2232 0.336928392669865 3263 5281727 Similar to reservatol, lowers cholesterol. SGTC_312 4092-0653 6.84 µM -0.421563377536828 0.328202806544359 no 2233 0.336671871061176 3220 1148278 SGTC_514 4466-0038 2.65 nM -0.422595796481178 0.32783165061784 no 2234 0.336295097015697 3149 5722064 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.422667981807875 0.327805706255519 no 2235 0.336268759630936 3254 521171 SGTC_3222 9128301 49.47 µM -0.422859665429042 0.327736816657804 no 2236 0.336198826252884 3126 4911358 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.42432441951734 0.327210589180652 no 2237 0.335664616298998 3183 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.424325259864751 0.327210287375912 no 2238 0.335664309911365 3198 5379071 SGTC_381 3461-2219 42.7 µM -0.425258054586919 0.326875350547743 no 2239 0.335324283730026 3236 2883159 SGTC_2480 5767542 37.17 µM -0.427706292012148 0.325996930381913 no 2240 0.334432484198603 3168 2867358 SGTC_2048 5246248 200 µM -0.428191548053847 0.325822936398074 no 2241 0.334255834619283 3271 677046 SGTC_3135 9127742 49.47 µM -0.429108688817736 0.325494188925116 no 2242 0.333922064683227 3192 3643468 SGTC_554 4483-2211 187 µM -0.430130296723577 0.32512815516991 no 2243 0.333550431232711 3224 747107 SGTC_1838 st055369 84.5 µM -0.43137769403898 0.324681451665131 no 2244 0.33309688308927 3202 676036 SGTC_1772 st048439 82.2 µM -0.432964988586571 0.32411339255573 no 2245 0.332520102662716 3241 2927068 YDL195W SEC31 SGTC_1450 4112-4260 37.6 µM -0.433004849355627 0.32409913249291 no 2246 0.332505623419735 3289 1633175 SGTC_3 0833-0587 95.581 µM -0.433107485531721 0.324062415916534 no 2247 0.33246834244602 3218 5382644 SGTC_2727 riluzole 51.77 µM -0.43311308934336 0.324060411284938 no 2248 0.33246630699745 3212 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1064 honokiol 6.76 µM -0.433179855267662 0.324036527740923 no 2249 0.332442056275973 3234 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.434265160764876 0.323648393283041 no 2250 0.332047949999343 3299 688798 SGTC_1229 0139-0193 12.2 µM -0.434891750480509 0.323424395215948 no 2251 0.331820501416835 3303 3090752 SGTC_1575 cyproterone acetate 48 µM -0.437637620209199 0.322443536201775 no 2252 0.330824497769657 3195 9880 An androgen receptor antagonist and liver toxin. SGTC_2478 5763493 32.33 µM -0.438208939285446 0.322239608830188 no 2253 0.330617414514248 3144 1365576 YLR208W SEC13 SGTC_2796 7949634 45.45 µM -0.439206937209608 0.321883510521337 no 2254 0.330255799444784 3149 2971588 SGTC_111 0083-0039 52.457 µM -0.440414759418324 0.321452762951951 no 2255 0.329818368516087 3110 759313 SGTC_62 0180-0423 3.232 µM -0.440950590954488 0.32126174530699 no 2256 0.329624383550222 3204 30102 YGL099W LSG1 SGTC_3228 9131799 49.47 µM -0.441386990429423 0.321106208948394 no 2257 0.329466429438256 3227 17015818 SGTC_1351 1496-0003 46.5 µM -0.443228988651104 0.320450051656426 no 2258 0.328800056536989 3308 3891978 SGTC_284 0988-0104 32.6 µM -0.444053263534821 0.320156609659345 no 2259 0.328502037671742 3239 4666532 SGTC_1008 4106-0037 6 µM -0.444859847793235 0.319869574377149 no 2260 0.328210520475478 3103 2905394 SGTC_1999 st074831 12.5 µM -0.448349748038129 0.318628884542466 no 2261 0.326950401312279 3191 17112523 SGTC_3016 9080866 49.47 µM -0.448765223054472 0.318481314564017 no 2262 0.326800514258527 3187 17066299 SGTC_1391 3442-0225 151 µM -0.449830142460558 0.318103204005433 no 2263 0.32641646085083 3150 5227075 SGTC_1261 0712-0010 12.7 µM -0.449970208161174 0.31805348633443 no 2264 0.326365961121074 3356 2840123 SGTC_601 0986-0029 62.9 µM -0.453851122117599 0.316677225118267 no 2265 0.3249679927426 3236 24747981 SGTC_1534 6-azauridine 81.6 µM -0.454344451441 0.316502460336673 no 2266 0.324790463381731 3219 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2953 9074162 66.49 µM -0.45448912267002 0.316451217478562 no 2267 0.324738409574405 3289 16451992 SGTC_2305 7443522 69.23 µM -0.455918305937965 0.315945187180258 no 2268 0.324224362622522 3217 5415886 SGTC_2103 5378138 10 µM -0.456154548360598 0.31586157410115 no 2269 0.324139423453148 3325 244142 SGTC_585 0kpi-0023 191 µM -0.457778097373647 0.315287207813074 no 2270 0.323555936524051 3291 64601 SGTC_868 0527-0199 213 µM -0.458677546912317 0.314969199642926 no 2271 0.323232870075809 3205 2849450 SGTC_3142 9086498 49.47 µM -0.459085528350397 0.31482499946272 no 2272 0.323086374239493 3264 25236367 SGTC_827 3253-0474 693 µM -0.459694465059559 0.314609824578389 no 2273 0.322867771478384 3316 5402065 SGTC_3201 9113999 49.47 µM -0.459815079823733 0.314567211412195 no 2274 0.322824479128585 3335 16649224 SGTC_1868 st057644 42.7 µM -0.460238509655597 0.314417633317091 no 2275 0.322672516146988 3183 688665 SGTC_600 1495-0418 41.6 µM -0.460437162117368 0.314347469124521 no 2276 0.322601232789945 3231 5377768 SGTC_3121 9125696 49.47 µM -0.461019665250987 0.314141767271921 no 2277 0.322392248164855 3244 1235365 SGTC_2282 7944268 200 µM -0.461288721536518 0.314046773745342 no 2278 0.322295737794539 3379 2970414 SGTC_1643 st009866 20.2 µM -0.461439889336562 0.313993407557747 no 2279 0.322241519226513 3292 3156273 YOR207C RET1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.461609019084976 0.313933704943119 no 2280 0.322180862822627 3280 1241132 A phosphatase inhibitor. SGTC_1902 st060212 70.5 µM -0.462602274295765 0.313583185280588 no 2281 0.321824739080394 3335 688944 SGTC_3203 9113543 49.47 µM -0.462750801677881 0.313530784435935 no 2282 0.321771499824911 3311 17018012 SGTC_2086 5274770 176.623 µM -0.462826491820189 0.313504082205233 no 2283 0.321744370296816 3272 689278 SGTC_826 1683-5028 118 µM -0.462978355590984 0.313450510125562 no 2284 0.321689940811675 3295 722377 SGTC_340 k038-0059 454 µM -0.4633193090476 0.313330248338162 no 2285 0.32156775364531 3295 23733424 SGTC_1002 4049-0206 172 µM -0.463651343489672 0.313213151557613 no 2286 0.321448781327325 3222 4662749 SGTC_229 benomyl 22.8748 µM -0.464012510313245 0.313085802200904 no 2287 0.321319391288282 3289 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_344 k064-0035 6.43 µM -0.465063934177452 0.312715191476735 no 2288 0.320942836281699 3192 5088750 SGTC_2206 7254556 146.969 µM -0.46609593141866 0.312351612367663 no 2289 0.320573417700356 3257 4398905 SGTC_1756 st041558 35.5 µM -0.466163499294447 0.312327814146834 no 2290 0.320549236979164 3386 3955792 SGTC_769 0302-0231 76 µM -0.466212572543649 0.312310530447323 no 2291 0.320531675463677 3318 571869 YER009W NTF2 SGTC_1444 4112-3581 28 µM -0.46622339374109 0.312306719254855 no 2292 0.320527803008186 3259 2877249 SGTC_2430 5571206 200 µM -0.466258321672915 0.312294417881671 no 2293 0.320515303890634 3371 1731771 SGTC_458 nppb 133 µM -0.466413203640807 0.312239872057432 no 2294 0.320459881134298 3387 4549 A chloride channel blocker. SGTC_2098 5376439 882.5 nM -0.466753137058025 0.312120169848337 no 2295 0.320338253852371 3303 2844116 SGTC_2612 dictamnine 15.46 µM -0.466830426731909 0.312092956271642 no 2296 0.32031060250256 3258 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2033 5192550 145 µM -0.467498819704606 0.311857658911892 no 2297 0.320071518170693 3229 182073 SGTC_2965 9082772 38.63 µM -0.469587080896682 0.311123013951933 no 2298 0.319325028253573 3388 16459634 SGTC_2217 6934799 96.0675 µM -0.469906022044444 0.311010877383989 no 2299 0.319211080829671 3297 675606 SGTC_1853 st056710 91.2 µM -0.470369548519226 0.310847937317022 no 2300 0.319045508159374 3376 269167 SGTC_2972 9093619 59.92 µM -0.470558651065684 0.310781474132231 no 2301 0.318977970681416 3171 25236256 SGTC_492 tmb-8 126 µM -0.471717106194462 0.310374450936223 no 2302 0.318564362715111 3252 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_926 2268-1401 59.4 µM -0.471851942830715 0.310327091157022 no 2303 0.318516236112587 3315 2931578 SGTC_1622 st003707 19.4 µM -0.472732199619201 0.310017988646502 no 2304 0.318202125494289 3324 10140899 SGTC_1287 0971-0001 34.6 µM -0.472737230249021 0.310016222524431 no 2305 0.318200330740943 3293 4665869 SGTC_422 cantharidin 155 µM -0.473666605712929 0.30969001844051 no 2306 0.317868835243338 3190 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2449 5812982 45.77 µM -0.474161850331781 0.309516252327431 no 2307 0.317692247844545 3317 776185 SGTC_2643 anethole 100 µM -0.474186935519884 0.309507451838628 no 2308 0.317683304422045 3301 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.474436007909101 0.309420077166727 no 2309 0.317594510397848 3257 65057 A dermal irritant. YDR527W RBA50 SGTC_684 1140-0066 328 µM -0.474499944965173 0.30939764976501 no 2310 0.317571718602071 3311 6813534 SGTC_1569 carminic acid 40.6 µM -0.47514733491626 0.309170602761427 no 2311 0.317340980911152 3367 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2020 4017018 200 µM -0.475215568262431 0.309146676795546 no 2312 0.317316665845284 3323 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_993 3909-8757 62.7 µM -0.476244424286512 0.308786007458234 no 2313 0.316950126919295 3222 4288324 YLR208W SEC13 SGTC_3291 9121177 71.43 µM -0.477221293516858 0.308443732868799 no 2314 0.316602274912458 3253 17015612 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.477356493317253 0.308396374784388 no 2315 0.316554144569471 3345 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_727 3032-0951 202 µM -0.477456219865586 0.308361444392103 no 2316 0.316518644488565 3271 3652836 SGTC_1049 3226-0134 66 µM -0.477646372598754 0.308294845976824 no 2317 0.316450959700842 3315 5702385 SGTC_3130 9127414 49.47 µM -0.47879983662517 0.307890996128835 no 2318 0.316040516462122 3316 1494646 SGTC_1897 st060201 15 µM -0.478872476700735 0.307865571226794 no 2319 0.31601467613835 3255 611878 SGTC_197 4544-0043 41.561 µM -0.47936121659993 0.307694530357101 no 2320 0.315840839599247 3304 896523 SGTC_1412 3909-8563 178 µM -0.481551727201005 0.306928446525708 no 2321 0.315062212648355 3365 23767530 SGTC_2767 sibutramine 71.45 µM -0.484488921577735 0.305902548267671 no 2322 0.314019462385258 3425 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.487192803053913 0.304959485212548 no 2323 0.31306085253173 3405 165506 SGTC_1514 1189-1591 158 µM -0.489009138300839 0.304326707700654 no 2324 0.312417613607374 3410 767698 YMR146C TIF34 SGTC_964 1287-0107 19.4 µM -0.490879900048566 0.303675580894382 no 2325 0.311755697038786 3386 51516812 YPR165W RHO1 SGTC_905 2-aminofluorene 215 µM -0.492401565291166 0.303146417721655 no 2326 0.311217746480346 3341 1539 An established DNA mutagen. YPR165W RHO1 SGTC_946 3434-1334 87.4 µM -0.493400470172891 0.302799270242977 no 2327 0.31086482510856 3338 4047976 SGTC_2456 5770359 74.46 µM -0.493559601837547 0.302743983966782 no 2328 0.310808618624096 3380 3118787 SGTC_2552 juarezic acid 87.02 µM -0.494618318757926 0.302376274689887 no 2329 0.310434784387093 3307 1549512 SGTC_2395 5646831 180.19 µM -0.495253652241883 0.302155709454129 no 2330 0.31021054130041 3412 6808628 SGTC_2297 7971671 152.32 µM -0.496529542818364 0.301712983835708 no 2331 0.309760424600393 3397 909016 SGTC_367 0335-0881 7.1 µM -0.498018553858398 0.301196675973229 no 2332 0.309235482430083 3393 23828853 SGTC_2883 9059145 45.46 µM -0.498254350199627 0.301114951173763 no 2333 0.309152389470653 3233 16476510 SGTC_1009 4106-0057 9.87 µM -0.499074982046679 0.30083060581076 no 2334 0.308863280751036 3409 2928005 SGTC_2316 5844804 197.44 µM -0.501310279907683 0.300056699847425 no 2335 0.308076385810455 3340 776813 SGTC_3038 9091290 49.47 µM -0.501585846018297 0.299961355599499 no 2336 0.307979438857686 3404 25236843 SGTC_1602 st001878 87.6 µM -0.502753278638877 0.299557582964395 no 2337 0.307568872911278 3407 595405 YLR310C CDC25 SGTC_2683 piperine 63.03 µM -0.504498883513782 0.298954301472708 no 2338 0.306955423277026 3302 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2765 myclobutanil 7.74 µM -0.505106239325734 0.29874452862616 no 2339 0.306742109664358 3394 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1317 1273-0028 910 nM -0.505364388847121 0.29865538738555 no 2340 0.306651463007148 3292 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1955 wogonin 32.4 µM -0.506786788509835 0.29816443765727 no 2341 0.306152213601906 3476 5281703 A flavanone. SGTC_2705 st078069 42.8 µM -0.507244101942915 0.298006671329405 no 2342 0.305991777116535 3335 1530061 SGTC_970 1315-0089 19.5 µM -0.509930716980851 0.297080598418954 no 2343 0.305050000605207 3362 6811083 YLR033W RSC58 SGTC_1302 1159-0335 255 µM -0.512622664783649 0.296154009453923 no 2344 0.304107647908358 3309 649284 SGTC_814 3342-0569 96 µM -0.516406152674269 0.294853950384247 no 2345 0.302785384731471 3442 4346283 SGTC_2857 9024691 58.44 µM -0.516544834462963 0.294806347409694 no 2346 0.302736966810306 3380 16478292 SGTC_505 gw-5074 63.9 µM -0.516766790425903 0.294730167678188 no 2347 0.302659482625533 3399 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3298 9116858 71.43 µM -0.517487977418829 0.294482704548168 no 2348 0.302407779695974 3411 2506942 SGTC_2978 9011784 42.97 µM -0.517728558485977 0.294400174556684 no 2349 0.302323834898004 3359 2994934 SGTC_1171 0368-0077 21.4 µM -0.517734294203945 0.294398207081001 no 2350 0.30232183368903 3290 3239779 SGTC_14 0354-0009 295 µM -0.517818118161523 0.294369454337877 no 2351 0.302292587940219 3341 1713507 SGTC_1356 1502-0781 85.8 µM -0.51849839066248 0.29413615970909 no 2352 0.302055291320405 3292 567702 SGTC_2214 7179297 48.276 µM -0.519646190092221 0.293742723856124 no 2353 0.301655098991337 3371 769744 SGTC_1875 nocodazole 6 µM -0.519725151432264 0.293715666913344 no 2354 0.301627577058774 3428 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_809 3998-0021 90 µM -0.52005752225339 0.293601789164813 no 2355 0.301511741772156 3391 715485 SGTC_2958 9077254 16.72 µM -0.520820561783854 0.293340431954523 no 2356 0.301245888940804 3466 16457351 SGTC_3304 9125678 46.087 µM -0.520915383211731 0.293307961138697 no 2357 0.301212859306744 3309 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2374 9071832 200 µM -0.521564638179823 0.29308567389608 no 2358 0.300986744835224 3406 17381698 SGTC_2783 7738165 71.43 µM -0.522038272523321 0.292923563687065 no 2359 0.300821841628251 3309 17201110 SGTC_723 4182-0001 115 µM -0.522213722582125 0.292863523188454 no 2360 0.300760766291895 3326 744821 YLR208W SEC13 SGTC_2779 methotrexate 400 µM -0.523077506927793 0.292568012183302 no 2361 0.300460158811282 3430 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2248 tofa 1.1 µM -0.52348094665256 0.292430038090753 no 2362 0.300319803382436 3259 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1711 st032263 62.8 µM -0.524140050678345 0.292204693361526 no 2363 0.300090566907945 3358 3958979 SGTC_3344 9148862 3.898 µM -0.524341830151893 0.29213572201501 no 2364 0.300020403805286 3453 4905352 SGTC_2236 dapsone 200 µM -0.524370222302878 0.292126017746489 no 2365 0.3000105318338 3397 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_460 trequinsin 123 µM -0.525261537239578 0.291821447905021 no 2366 0.299700695742995 3431 5537 A vasodilator. SGTC_1108 betulinic acid 729.144 nM -0.526001666670583 0.291568651908051 no 2367 0.299443524484751 3349 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2431 5490079 200 µM -0.526789370603101 0.291299718754752 no 2368 0.299169932572127 3363 5722345 SGTC_2892 9047358 58.44 µM -0.527004521091557 0.291226283499594 no 2369 0.299095224436325 3324 6466771 SGTC_1191 1487-1166 10.6 µM -0.527487003746021 0.29106163374692 no 2370 0.298927719573333 3414 3955771 SGTC_2265 7929201 200 µM -0.527537226141558 0.291044497588263 no 2371 0.298910286171625 3245 1265108 SGTC_2114 5491910 81.25 µM -0.5276563721535 0.291003846196514 no 2372 0.298868929572228 3429 2849228 SGTC_2937 9044753 11.33 µM -0.527782523545692 0.290960807532722 no 2373 0.298825144179188 3358 6465530 YGL099W LSG1 SGTC_1246 0422-0085 105 µM -0.52778445579662 0.29096014833603 no 2374 0.298824473544441 3452 264295 SGTC_2492 derrusnin 100 µM -0.528635418787615 0.290669906074799 no 2375 0.298529192612483 3352 1715307 Part of coumarin class of compounds. SGTC_751 0833-0568 350 µM -0.529122007818899 0.290504003568208 no 2376 0.298360407733014 3385 6954252 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.529591418134182 0.290344000153511 no 2377 0.298197622872633 3296 2724 A muscle relaxant with antifungal properties. SGTC_1870 st057514 26.5 µM -0.529851771939333 0.290255273631709 no 2378 0.29810735329723 3306 5393161 SGTC_1308 1187-1617 41.4 µM -0.530862161182354 0.289911061295415 no 2379 0.297757150255694 3359 2882570 SGTC_647 0140-0236 81 µM -0.532398154888778 0.289388156731695 no 2380 0.297225131416822 3376 990837 SGTC_1433 4060-0023 7.6 µM -0.532563384591202 0.289331933321248 no 2381 0.297167927050911 3427 3840627 SGTC_2771 fluoxetine 41.05 µM -0.534652068932642 0.288621650810225 no 2382 0.296445235592817 3470 3386 A selective serotonin reuptake inhibitor. SGTC_1819 st053448 58.6 µM -0.536014346320019 0.288158834813679 no 2383 0.295974317716848 3318 2857616 SGTC_557 1315-0110 16.2 µM -0.53613379543802 0.288118270234311 no 2384 0.295933042417118 3385 6833801 SGTC_342 k048-0088 23.3 µM -0.536811837103181 0.287888060294451 no 2385 0.295698797165358 3321 6820570 SGTC_3160 9100216 49.47 µM -0.536941321939379 0.287844107247161 no 2386 0.295654073310958 3386 17191039 SGTC_1920 st075728 45.7 µM -0.536942683285763 0.287843645161069 no 2387 0.29565360312062 3471 3400306 SGTC_1574 spiramycin 23.7 µM -0.537669174745629 0.287597099873193 no 2388 0.295402731998835 3381 6419898 An antibiotic and protein synthesis inhibitor. SGTC_834 0312-0008 75.7 µM -0.537932093054634 0.287507899383403 no 2389 0.295311965516914 3422 6385573 YIL048W NEO1 SGTC_280 3448-3607 3.04 µM -0.538934208889108 0.287168030810554 no 2390 0.294966125881456 3430 626179 SGTC_1922 5578187 25 µM -0.539180140383726 0.287084651975995 no 2391 0.294881281127183 3501 1350412 SGTC_3072 9116419 49.47 µM -0.539533712151164 0.286964799653675 no 2392 0.294759320898096 3377 17170162 SGTC_2356 9061756 188.97 µM -0.539727112280307 0.286899251693136 no 2393 0.294692619746 3374 20104043 SGTC_2838 9002687 71.43 µM -0.540223863707366 0.286730923193415 no 2394 0.294521328645732 3315 6457060 SGTC_794 k038-0031 316 µM -0.541529544353655 0.28628870547423 no 2395 0.294071319744139 3474 6624242 SGTC_2981 9013952 38.96 µM -0.541987050048346 0.286133830660858 no 2396 0.293913713504794 3371 2996344 SGTC_2528 xanthyletin 44.79 µM -0.543004753058094 0.285789460682728 no 2397 0.293563264939047 3360 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1012 4112-3522 18 µM -0.543006023718823 0.285789030840245 no 2398 0.293562827504825 3455 3112398 SGTC_2593 nobiletin 86.24 µM -0.54383259909422 0.285509479906783 no 2399 0.293278336884474 3357 72344 An anti-infammatory. SGTC_2393 9031399 185.94 µM -0.543891986250131 0.285489399958311 no 2400 0.293257901941171 3480 1526623 YDL150W RPC53 SGTC_1250 0485-0349 40.2 µM -0.544112865643855 0.28541472225533 no 2401 0.293181903793408 3343 6842794 YDL195W SEC31 SGTC_928 2764-0428 58.7 µM -0.54415547255566 0.285400318241251 no 2402 0.293167245050268 3427 662578 SGTC_2150 5556613 200 µM -0.54484387036631 0.285167641277914 no 2403 0.292930451565074 3370 743190 SGTC_2120 5538279 151.968 µM -0.545097521925617 0.285081930401205 no 2404 0.292843223472067 3432 2058197 SGTC_1947 st076332 61.6 µM -0.54836829166809 0.283977813023722 no 2405 0.291719522057181 3465 24208416 SGTC_2089 5281248 129.67 µM -0.548579631672855 0.283906541178321 no 2406 0.291646983528141 3449 2737878 SGTC_2117 5521686 200 µM -0.548732197995023 0.283855095363788 no 2407 0.291594623199863 3372 803312 SGTC_1467 k284-1082 293 µM -0.550413082502456 0.283288591764498 no 2408 0.291018038778038 3440 3334705 SGTC_2726 cimetidine 79.27 µM -0.550966900459124 0.283102058943562 no 2409 0.290828182423171 3405 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2190 6049624 200 µM -0.551333574419412 0.282978591002839 no 2410 0.290702513452559 3401 2265554 SGTC_2390 9097792 176.6 µM -0.551450302745679 0.282939291193548 no 2411 0.29066251286398 3362 4497149 SGTC_410 α-linolenic acid 100 µM -0.553028858809581 0.282408084284742 no 2412 0.290121824572428 3471 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_45 0kpi-0036 14.9 µM -0.553221225533085 0.282343382909666 no 2413 0.290055967200114 3453 2795021 SGTC_3067 9117431 49.47 µM -0.554442377560073 0.281932822278938 no 2414 0.289638065361913 3374 17150885 SGTC_1820 st053765 18.6 µM -0.554931486203105 0.281768460924754 no 2415 0.289470762234313 3432 3690829 SGTC_2912 7964298 10.93 µM -0.556655866320835 0.28118936442835 no 2416 0.28888128801332 3443 2975850 SGTC_3355 9151058 44.0485 µM -0.557224146996249 0.280998645412068 no 2417 0.288687146796593 3463 17015728 SGTC_1055 3448-0672 86 µM -0.557569440201648 0.280882793105902 no 2418 0.288569214606692 3449 748378 SGTC_2656 pseudo-anisatin 100 µM -0.55837039093026 0.280614148140718 no 2419 0.288295743583571 3430 6708809 A neurotoxin. SGTC_78 0336-0123 156.75 µM -0.560483574464129 0.279905967570796 no 2420 0.287574820149406 3254 6765896 SGTC_523 1934-0222 13.7 µM -0.561362238597136 0.279611760606362 no 2421 0.287275310416372 3381 1361595 SGTC_1358 1509-0022 2.48 µM -0.56165581065825 0.279513496051627 no 2422 0.287175273587742 3453 3258434 SGTC_3165 9101544 49.47 µM -0.562120517465493 0.279357983496155 no 2423 0.287016955061765 3455 5002184 SGTC_1733 st037357 54.9 µM -0.563057539630609 0.279044540096318 no 2424 0.28669785166705 3393 1272339 YGL099W LSG1 SGTC_1499 4480-0877 67.3 µM -0.564425226757148 0.278587342136381 no 2425 0.286232387273319 3432 2861909 SGTC_485 niflumic acid 177 µM -0.564990378375337 0.278398526733086 no 2426 0.286040154297431 3475 4488 A COX2 inhibitor. SGTC_978 1416-0512 87.4 µM -0.565173308671368 0.278337423651183 no 2427 0.285977944785986 3466 6814003 SGTC_2429 5902844 64.44 µM -0.567173845810869 0.277669623501349 no 2428 0.285298037743265 3441 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3062 9077494 49.47 µM -0.569162675752879 0.277006508067301 no 2429 0.284622873796913 3443 16459633 SGTC_2931 9014674 55.67 µM -0.569190668710309 0.276997180193972 no 2430 0.284613376251545 3380 2996810 SGTC_733 4069-0007 56.1 µM -0.571505003619414 0.276226524863048 no 2431 0.283828684774175 3499 5717425 YNL287W SEC21 SGTC_255 tunicamycin 200.472 nM -0.571628360264715 0.276185477624336 no 2432 0.28378688892864 3425 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2622 2-methoxyxanthone 59.94 µM -0.572230713883185 0.275985085930094 no 2433 0.283582841096449 3420 71034 A hepatoprotective. SGTC_2979 9012552 45.46 µM -0.575078212504253 0.275038744605852 no 2434 0.282619201145846 3543 17100905 SGTC_426 0988-0037 14.6 µM -0.577980919092253 0.27407570352456 no 2435 0.28163850080572 3524 5383008 SGTC_1954 st077032 68.9 µM -0.580820060998723 0.27313536612939 no 2436 0.280680866556163 3437 698907 SGTC_3046 9092212 49.47 µM -0.58325822466745 0.27232911271107 no 2437 0.279859740234096 3490 25236637 SGTC_1976 st070609 63.5 µM -0.583908073965735 0.272114419897878 no 2438 0.279641080390587 3467 682556 SGTC_917 harmaline 728.087 nM -0.584421249145188 0.271944940035254 no 2439 0.279468466966564 3444 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1369 1866-0067 208 µM -0.584705777987669 0.271850994931477 no 2440 0.279372784139021 3522 3531355 SGTC_3163 9099914 49.47 µM -0.585116999485725 0.271715247266379 no 2441 0.279234524578777 3510 16268368 SGTC_643 k048-0106 28.4 µM -0.586145305327278 0.271375942630622 no 2442 0.278888936539583 3507 6763920 SGTC_2394 5221648 200 µM -0.587393324757744 0.270964424076672 no 2443 0.278469787974452 3519 788586 SGTC_233 rapamycin 362 pM -0.58755086415799 0.270912499600492 no 2444 0.278416900035142 3500 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_145 3737-0113 38.366 µM -0.588568392721572 0.270577245128993 no 2445 0.278075420973401 3537 6849351 SGTC_757 1066-0008 322 µM -0.589205509628514 0.27036743393356 no 2446 0.277861710814096 3501 6842497 SGTC_1980 st071811 45.7 µM -0.589517075202865 0.27026486080121 no 2447 0.277757230577996 3563 4974850 SGTC_1852 st056254 31.4 µM -0.590777339325817 0.269850157243586 no 2448 0.277334810121716 3421 442583 SGTC_2889 9059656 51.95 µM -0.591297066177633 0.269679228322847 no 2449 0.277160697496609 3503 3949838 SGTC_2586 curcumin 80 µM -0.591481364394795 0.269618628944264 no 2450 0.277098968976966 3485 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_909 3448-9333 149 µM -0.592318709277272 0.269343386234797 no 2451 0.276818594913483 3467 3344074 SGTC_2563 tomatine 8.54 µM -0.593645053016017 0.268907693784213 no 2452 0.276374770494908 3554 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_275 trichlorophene 5.69 µM -0.5942305912026 0.268715462209637 no 2453 0.276178947377285 3512 62616 SGTC_396 dithiazanine 1.25 µM -0.59642034638116 0.267997180281475 no 2454 0.275447225745736 3431 10578 An antihelmenthic. SGTC_762 1165-0429 115 µM -0.596683332725166 0.26791098075574 no 2455 0.27535941125556 3511 5967793 SGTC_1141 3253-0389 52.6 µM -0.59677086468661 0.267882293338603 no 2456 0.275330186274721 3490 5402031 SGTC_1032 k061-1018 98.7 µM -0.597492502509863 0.267645845269779 no 2457 0.275089305593493 3596 4005393 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.597630729748795 0.2676005664643 no 2458 0.275043177576303 3468 2374 Ca(2+)-ATPase inhibitor. SGTC_3218 9131285 49.47 µM -0.597974365322069 0.267488019218329 no 2459 0.274928518951177 3565 17156417 SGTC_2260 7964312 200 µM -0.598099843201641 0.267446928754577 no 2460 0.274886657442307 3566 231951 SGTC_686 1319-0111 510 µM -0.598184421651664 0.267419233495786 no 2461 0.274858442436207 3575 4562600 SGTC_724 3910-0327 137 µM -0.599116971873889 0.267113965361 no 2462 0.274547442370686 3510 2885483 SGTC_3028 9087778 49.47 µM -0.599438428979682 0.267008777918132 no 2463 0.274440278549932 3432 17217395 SGTC_1588 farnesol 29.9 µM -0.599883841413304 0.266863064298696 no 2464 0.274291825997784 3545 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1244 0416-0015 52.5 µM -0.600228078603993 0.266750476995712 no 2465 0.27417712154854 3485 96201 SGTC_2207 7258803 200 µM -0.601548036193655 0.266318990126649 no 2466 0.27373751369935 3505 3666799 SGTC_678 1218-2179 85.9 µM -0.602239462794054 0.266093107634083 no 2467 0.273507375404256 3504 6820081 YOR116C RPO31 SGTC_1712 st032288 53.4 µM -0.602619506834148 0.265968992195262 no 2468 0.273380920221123 3540 2883011 SGTC_843 0310-0051 143 µM -0.603239912893192 0.26576644195064 no 2469 0.273174549630394 3494 2065037 SGTC_2 0422-0095 29 µM -0.604237184854927 0.265441016431247 no 2470 0.272842980994179 3438 6790840 SGTC_3245 9134821 49.47 µM -0.604398507507244 0.265388393319255 no 2471 0.272789363904867 3447 17014901 SGTC_1028 k015-0029 4.8 µM -0.607866787719537 0.264258329519938 no 2472 0.27163791437257 3535 4588309 SGTC_1237 0330-0133 46.1 µM -0.60841484423145 0.264079981663357 no 2473 0.271456184341794 3488 X1237 YHR072W ERG7 SGTC_2408 sulbentine 18.36 µM -0.609427827445835 0.263750499453662 no 2474 0.271120448798281 3402 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_960 1222-0186 7.7 µM -0.611310025281901 0.263138854273231 no 2475 0.270497177624013 3540 3126296 SGTC_609 0986-0026 86.3 µM -0.611723282023247 0.263004658099903 no 2476 0.270360427656593 3523 2848610 SGTC_2925 9010536 32.5 µM -0.613213452575394 0.262521048157274 no 2477 0.269867605429233 3531 2994177 SGTC_1266 0828-0227 32.9 µM -0.614050230421014 0.262249685595821 no 2478 0.269591067483354 3474 3913820 SGTC_200 k038-0079 37.545 µM -0.614068896983 0.262243633768928 no 2479 0.269584900186153 3472 3436683 SGTC_3120 9124077 49.47 µM -0.614174979688977 0.262209242389738 no 2480 0.269549852569107 3554 18774327 YGL155W CDC43 SGTC_2239 6685329 187.64 µM -0.615800148079443 0.261682661527991 no 2481 0.269013214832562 3548 805680 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.616735133905746 0.26137995707686 no 2482 0.268704721598408 3562 5282362 SGTC_1464 k208-0027 110 µM -0.618906261389455 0.260677742389494 no 2483 0.267989056707829 3586 X1464 SGTC_1857 st056007 79.3 µM -0.621961077956513 0.259691360043336 no 2484 0.266983730769463 3571 619834 SGTC_1419 3993-2473 62.6 µM -0.622363134736002 0.259561681877342 no 2485 0.266851557733778 3563 704026 SGTC_902 1120-0002 2.07 µM -0.622386933363168 0.259554006989093 no 2486 0.266843735156917 3564 3280475 SGTC_785 1270-0111 65.3 µM -0.623324881665909 0.259251618666246 no 2487 0.266535525105165 3550 6741994 SGTC_2349 9023730 187.07 µM -0.623408798402861 0.259224573341977 no 2488 0.26650795882098 3560 4126287 SGTC_1131 3454-3128 32.3 µM -0.623678415906721 0.259137688832352 no 2489 0.266419400400543 3536 710982 SGTC_1274 0865-0114 173 µM -0.625996672635177 0.258391250017375 no 2490 0.265658561893382 3535 870624 SGTC_1227 3909-8010 46.6 µM -0.629375373792351 0.257305364617401 no 2491 0.264551668143049 3534 15982272 SGTC_192 3455-0609 60.9 µM -0.629569887210595 0.257242921965075 no 2492 0.264488015253678 3618 3769639 SGTC_3329 9141233 27.5565 µM -0.630189793304829 0.25704397242378 no 2493 0.264285208178979 3577 4909101 YNL103W MET4 SGTC_390 dec-rvkr-cmk 16.7 µM -0.631122836164643 0.256744677296379 no 2494 0.263980105342452 3583 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3012 9080433 71.4286 µM -0.631713921187428 0.256555166984414 no 2495 0.263786914843517 3588 17688859 SGTC_2202 7226349 200 µM -0.634499917402142 0.255662918758499 no 2496 0.262877310349528 3526 844334 SGTC_3109 9122853 49.47 µM -0.635649331725409 0.2552952779761 no 2497 0.262502504052192 3575 1234709 SGTC_1959 st077091 55.8 µM -0.637435186166579 0.254724620222643 no 2498 0.261920707615014 3582 821356 YKL052C ASK1 SGTC_903 1134-0042 114 µM -0.637895412900438 0.254577666186149 no 2499 0.261770881975883 3539 701009 SGTC_1757 st041620 31.8375 µM -0.638233949113607 0.254469597250782 no 2500 0.261660700447535 3568 5289815 SGTC_3192 9110362 49.47 µM -0.640642019343729 0.253701577252907 no 2501 0.260877646315716 3640 16649480 SGTC_499 genistein 192 µM -0.641697602128701 0.253365298175008 no 2502 0.260534773227819 3589 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2782 7736369 71.43 µM -0.64183326497546 0.253322096792817 no 2503 0.260490724222549 3609 2950836 YOL077C BRX1 SGTC_2388 9080168 200 µM -0.642219147515627 0.253199234957925 no 2504 0.260365451184262 3529 15943073 SGTC_1673 st016611 27.3 µM -0.642771267848827 0.253023498882578 no 2505 0.260186264636248 3598 5226799 SGTC_1180 1193-0155 285 µM -0.643303661011734 0.252854102624864 no 2506 0.260013540607033 3583 2921347 SGTC_2244 6635614 200 µM -0.644112875418453 0.252596742068729 no 2507 0.259751120890802 3476 836499 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.644173462126919 0.252577478775204 no 2508 0.25973147875995 3558 5711223 A potent inhibitor of glutathione S-transferases. SGTC_612 0302-0167 22.4 µM -0.645118836032508 0.252277001328138 no 2509 0.259425089117648 3605 235821 SGTC_2569 tetrandrine 100 µM -0.645887378190217 0.252032867008502 no 2510 0.259176147166739 3533 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3332 9141069 11.198 µM -0.646443683147431 0.251856229543197 no 2511 0.258996028995772 3568 17332883 SGTC_929 2805-0021 398 µM -0.646888813685064 0.251714939161947 no 2512 0.258851953069598 3589 3098024 SGTC_923 1900-2434 73.3 µM -0.646901381995315 0.251710950420024 no 2513 0.258847885671857 3580 5910570 SGTC_1375 2910-0797 186 µM -0.647753479787377 0.251440602258084 no 2514 0.258572204135018 3560 742508 SGTC_1550 gossypolone 36.6 µM -0.647927163135039 0.251385515944941 no 2515 0.258516030544588 3604 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.648141134806513 0.251317660349011 no 2516 0.258446835381227 3569 803109 SGTC_3009 9080819 71.4286 µM -0.648304573480163 0.251265836513558 no 2517 0.258393988279718 3583 17027216 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.648446429578283 0.25122086075469 no 2518 0.258348124338173 3621 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2363 9053361 176 µM -0.648924482735424 0.251069324401367 no 2519 0.25819359453408 3647 6469797 YMR079W SEC14 SGTC_1618 st003135 44.5 µM -0.649198839769817 0.25098237879586 no 2520 0.258104930773132 3544 1270615 SGTC_659 k018-0002 107 µM -0.652629874671901 0.249896407477486 no 2521 0.256997460512039 3599 6797879 YHR007C ERG11 SGTC_2108 5365811 200 µM -0.653215943344209 0.249711158127536 no 2522 0.256808536616099 3615 780283 SGTC_1014 4130-3005 69.3 µM -0.654360702688205 0.249349523740697 no 2523 0.256439722943628 3624 743608 SGTC_147 4466-0538 29.23 µM -0.654405917441852 0.249335245923616 no 2524 0.256425161515114 3684 6742687 YHR072W ERG7 SGTC_1044 1222-0021 1.78 µM -0.65452607384792 0.249297305305942 no 2525 0.256386467192966 3560 4306703 SGTC_479 n-linoleoylglycine 10 µM -0.654561740935256 0.249286043648109 no 2526 0.256374981801235 3583 6433346 An anti-infammatory. SGTC_1865 st057639 52.2 µM -0.656323781083587 0.248730027502067 no 2527 0.255807909745306 3607 688818 SGTC_1859 st055998 20 µM -0.656664791128911 0.248622497256998 no 2528 0.255698239178453 3624 676301 SGTC_2442 5158906 48.48 µM -0.659146044819631 0.247840832972212 no 2529 0.254900995175511 3615 1893835 SGTC_223 busulfan 5 mM -0.659529911726829 0.247720021449861 no 2530 0.254777772378433 3597 2478 A DNA alkylator. SGTC_2804 7954240 19.48 µM -0.660592172348547 0.247385868200523 no 2531 0.254436945135868 3617 828705 SGTC_1647 st011722 22.4 µM -0.66064775548667 0.247368390156611 no 2532 0.254419117818179 3622 2854783 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.661956247804431 0.246957127216441 no 2533 0.253999630997412 3719 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_225 nsc-122657 1.016 µM -0.662042024153827 0.246930180244998 no 2534 0.253972144816693 3566 275685 SGTC_2168 5727979 200 µM -0.662331885288058 0.246839130894685 no 2535 0.2538792732399 3555 695210 SGTC_1197 1601-0112 267 µM -0.664047717375529 0.246300532790095 no 2536 0.253329885495637 3614 7350313 SGTC_2091 4-phenylthiadiazole 200 µM -0.664171624685507 0.246261662805539 no 2537 0.253290236150781 3615 270010 SGTC_618 k072-0232 33.2 µM -0.665241276343326 0.245926247609925 no 2538 0.25294809190189 3599 5872756 YGL099W LSG1 SGTC_2050 5263056 171 µM -0.667546332487912 0.24520427558416 no 2539 0.252211612472482 3628 763468 YGL055W OLE1 SGTC_3299 9121982 43.1275 µM -0.667805423957305 0.245123196247241 no 2540 0.25212890192863 3625 17594604 YPL160W CDC60 SGTC_788 1182-0090 188 µM -0.668582012818981 0.244880259171882 no 2541 0.251881074883298 3691 5715185 SGTC_943 3253-1379 105 µM -0.669249893562453 0.244671432488451 no 2542 0.251668041941481 3628 668464 SGTC_1689 st020265 53.493 µM -0.669693939129557 0.24453264557648 no 2543 0.251526458062659 3628 5758320 YPR016C TIF6 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.670526697949133 0.244272480307567 no 2544 0.251261046523508 3595 17037758 SGTC_2446 5162541 200 µM -0.671456964856727 0.243982028705162 no 2545 0.250964733036848 3601 1549321 SGTC_20 0481-0013 4.944 µM -0.672061162393239 0.243793483616467 no 2546 0.250772379978239 3617 182045 SGTC_2514 salinomycin 42.74 µM -0.672391414369105 0.243690458870526 no 2547 0.250667273564699 3677 23682228 A polyether potassium ionophore. SGTC_1125 tnp00248 1.32998 µM -0.672530136615043 0.243647190367726 no 2548 0.250623130606268 3714 24207736 SGTC_1487 3970-0795 2.82 µM -0.674212314965974 0.243122836700839 no 2549 0.250088170664743 3672 3765103 SGTC_504 lovastatin 124 µM -0.674860751097894 0.24292087502291 no 2550 0.249882119357287 3601 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1168 k815-0004 80.5 µM -0.675128380364267 0.24283754578061 no 2551 0.249797102009976 3626 642433 SGTC_369 0957-0393 4.5 µM -0.676054321615261 0.242549363419166 no 2552 0.249503078303196 3619 6997992 SGTC_156 3474-0145 5.642 µM -0.676089321406557 0.242538474005136 no 2553 0.249491968065354 3588 2265471 SGTC_3294 9122953 26.2835 µM -0.676178683394132 0.242510672192389 no 2554 0.249463602433429 3640 16459826 SGTC_3115 9123671 49.47 µM -0.677192622706864 0.242195341876629 no 2555 0.249141873927684 3713 3286988 SGTC_6 0844-0013 19.835 µM -0.680243986961656 0.241247724452867 no 2556 0.248174992320213 3740 1584900 SGTC_3124 9127567 49.47 µM -0.680381044869791 0.241205207727323 no 2557 0.248131609980885 3607 17592030 SGTC_920 mycophenolic acid 780.421 nM -0.680939784148088 0.241031923400338 no 2558 0.247954796549465 3650 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1436 4092-1007 8.32 µM -0.681379497765669 0.240895600651219 no 2559 0.247815696162602 3618 2881121 SGTC_556 4058-0063 51.5 µM -0.681864336492781 0.240745336566883 no 2560 0.247662369061222 3707 6615692 SGTC_771 0250-0039 27.3 µM -0.682090825599485 0.24067515920754 no 2561 0.247590760717123 3635 3005115 SGTC_765 1319-0117 244 µM -0.682455545538566 0.240562174607709 no 2562 0.247475471617581 3629 3487746 YGL099W LSG1 SGTC_1495 4469-0029 237 µM -0.684835527378278 0.239825602590469 no 2563 0.246723856886038 3666 793680 SGTC_1182 1222-0449 220 µM -0.68495896118687 0.239787435093404 no 2564 0.246684909003843 3629 658318 SGTC_1726 st035556 14.5795 µM -0.685895580173574 0.239497927131234 no 2565 0.246389478760983 3704 5919439 SGTC_365 0121-0052 13.6 µM -0.686351109414645 0.239357192525441 no 2566 0.246245863381511 3664 3101739 SGTC_3092 9117248 49.47 µM -0.686382919931035 0.239347366434549 no 2567 0.246235836109655 3702 17141857 SGTC_602 3130-1533 38.1 µM -0.687036910434875 0.239145401257374 no 2568 0.246029734554232 3669 720941 SGTC_355 1311-2252 105 µM -0.68866830786923 0.238641999726324 no 2569 0.245516012149674 3646 5338538 SGTC_2351 9026858 72.31 µM -0.691327480241053 0.237822701364146 no 2570 0.244679883088565 3605 1409300 SGTC_880 0833-0487 87.2 µM -0.693825943389653 0.237054325681301 no 2571 0.243895685384707 3653 76075 SGTC_1170 0310-0127 64.8 µM -0.694020093342232 0.236994674113654 no 2572 0.243834803985264 3656 774975 SGTC_747 3448-8087 38.7 µM -0.69438699772242 0.236881967173683 no 2573 0.243719772778785 3682 5168703 SGTC_2054 5233173 129 µM -0.695919419874824 0.236411551223875 no 2574 0.243239647391586 3683 6889 SGTC_1641 st009299 47.1 µM -0.697755325696366 0.23584865097498 no 2575 0.242665110961607 3619 4046054 SGTC_1843 st055809 45.5 µM -0.69955968425041 0.235296144007421 no 2576 0.242101163734244 3666 16413835 SGTC_2063 5246145 200 µM -0.699946585146222 0.235177765404217 no 2577 0.241980331533078 3693 711240 SGTC_2756 carbadox 75.1 µM -0.701091689339115 0.234827595006274 no 2578 0.24162289821633 3695 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1957 st077035 62.4 µM -0.702089253269979 0.234522777140302 no 2579 0.241311751957011 3731 705593 SGTC_1507 4075-3230 155 µM -0.702336452453964 0.234447276258102 no 2580 0.241234682701126 3606 659771 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.702531173565019 0.23438781297674 no 2581 0.241173983947148 3699 229346 A bile salt which induces apoptosis. SGTC_2785 7756463 72.73 µM -0.703028045998254 0.234236117561482 no 2582 0.241019135761238 3668 2201551 SGTC_1664 st014217 9.02 µM -0.703046228046395 0.234230567603613 no 2583 0.241013470428661 3727 3982782 SGTC_1531 st059297 52.4 µM -0.70315251895929 0.234198124415871 no 2584 0.240980352761261 3691 7566702 SGTC_2215 7188065 200 µM -0.703437828990833 0.234111051504863 no 2585 0.240891469322617 3684 940217 SGTC_2879 9041815 71.43 µM -0.703669974412816 0.234040216970931 no 2586 0.24081916156554 3634 4942971 SGTC_120 rhodamine 6G 52.259 µM -0.704833376458494 0.233685406972633 no 2587 0.240456967552084 3727 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2275 7947463 200 µM -0.705550767479458 0.233466768465967 no 2588 0.240233775063695 3630 1225414 SGTC_982 1491-0518 27.5 µM -0.705954448154193 0.233343789037928 no 2589 0.240108232827164 3653 3091256 SGTC_47 0149-0135 24.25 µM -0.706471097876709 0.233186446572196 no 2590 0.239947610093444 3672 5239155 SGTC_1195 1502-0147 41.1 µM -0.70829808947453 0.232630520252137 no 2591 0.239380081647506 3689 817940 SGTC_3041 9091929 49.47 µM -0.708872464134667 0.232455898942464 no 2592 0.239201812082639 3731 25236887 SGTC_1617 st002906 78 µM -0.710466502304475 0.231971661759634 no 2593 0.238707448209409 3710 5150859 SGTC_2854 9024559 71.43 µM -0.710716389363378 0.231895801988043 no 2594 0.238630000699495 3681 3163529 SGTC_2624 nerol 100 µM -0.710876171885337 0.231847303054854 no 2595 0.238580486502181 3639 637566 A natural product oil. SGTC_2327 6189656 200 µM -0.710916281481469 0.231835129440114 no 2596 0.238568058025392 3742 5349088 SGTC_1192 1488-0095 21.4 µM -0.712371899216203 0.231393577676728 no 2597 0.238117255935996 3705 915875 SGTC_455 paf C-16 10 µM -0.713235668898831 0.23113178088072 no 2598 0.237849968933594 3669 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_254 nsc-64875 3.808 µM -0.713775282397204 0.230968315316232 no 2599 0.237683073149799 3699 56993 SGTC_1945 st075991 56.6 µM -0.714141255257408 0.230857487593997 no 2600 0.23756991884262 3625 1084980 SGTC_2710 st078562 53.7235 µM -0.714899001519509 0.230628113385439 no 2601 0.237335727020737 3675 17250908 SGTC_1539 benzyladenosine 56 µM -0.715437938608011 0.230465051511105 no 2602 0.237169238337965 3688 92208 A nucleotide analog. SGTC_1646 st011709 75.6 µM -0.716291563630328 0.230206908957086 no 2603 0.236905667466306 3666 5757843 SGTC_2835 9006588 71.43 µM -0.716485699154048 0.230148223512848 no 2604 0.236845747389471 3707 2345538 SGTC_1581 himbacine 57.9 µM -0.716952732300197 0.23000707783286 no 2605 0.236701631397204 3707 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2208 7283366 200 µM -0.718197403915997 0.229631152736327 no 2606 0.236317789225084 3691 898663 SGTC_331 k048-0133 24.5 µM -0.720800317274361 0.228846114814834 no 2607 0.235516190095422 3674 6813582 SGTC_3123 9126162 49.47 µM -0.720935589656879 0.228805357921708 no 2608 0.235474572353816 3789 25239884 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.721692154427887 0.228577483873091 no 2609 0.23524188336424 3711 688667 SGTC_218 alverine citrate 93.75 µM -0.723359591762368 0.228075709262819 no 2610 0.234729495036928 3727 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1653 st012112 65 µM -0.724133020649306 0.227843175165888 no 2611 0.234492037022591 3715 720429 SGTC_2415 st077333 57.7 µM -0.724457141345168 0.227745766828169 no 2612 0.234392565067401 3732 2766255 SGTC_2065 5221596 34.26 µM -0.725397676387948 0.227463239564822 no 2613 0.234104049084901 3702 788581 SGTC_2657 nystatin 74.44 µM -0.726338932292043 0.227180693505658 no 2614 0.233815508975575 3737 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2674 ligustilide 100 µM -0.727605212940669 0.226800893835271 no 2615 0.233427644302664 3711 5319022 A signalling regulator. SGTC_170 4197-0004 226 µM -0.728028632543428 0.22667397618159 no 2616 0.233298029579408 3732 218692 SGTC_1636 st007707 68.9 µM -0.73128015387357 0.225700687676381 no 2617 0.232304025051959 3732 403051 SGTC_3337 9144342 33.5465 µM -0.73388574336901 0.224922457445763 no 2618 0.231509188363804 3745 17682949 SGTC_2778 tioconazole 65.09 nM -0.735940661897595 0.224309774402778 no 2619 0.230883405055152 3686 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_207 4185-0010 4.486 µM -0.736776068498531 0.224060965373216 no 2620 0.230629269403509 3793 3761753 SGTC_457 grayanotoxin iii 135 µM -0.737052708215592 0.223978608371164 no 2621 0.230545148418813 3680 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_820 1582-0060 59.9 µM -0.740528867956458 0.222945205552623 no 2622 0.229489575695262 3749 3848840 SGTC_1794 st048918 76.9 µM -0.743999321045088 0.221916213850613 no 2623 0.228438442929719 3663 672303 SGTC_2662 daunorubicin 22.37 µM -0.744858990808065 0.221661740937381 no 2624 0.228178484329624 3646 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2815 7968870 71.43 µM -0.745217370581996 0.22155570534403 no 2625 0.22807016173478 3754 2977326 YHR190W ERG9 SGTC_428 3448-4153 16.5 µM -0.745741823221784 0.221400585221554 no 2626 0.227911694686433 3724 3834874 SGTC_999 SEC7.066 22.7 µM -0.752383379629104 0.219441557158981 no 2627 0.225910269331073 3758 740511 YDR170C SEC7 SGTC_738 1315-0003 72.4 µM -0.752505592700348 0.219405602117684 no 2628 0.225873533921766 3752 6251474 SGTC_1827 berberine 7.24 µM -0.753212434941017 0.219197715800993 no 2629 0.225661134065565 3699 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2255 7941087 197.44 µM -0.754640070085045 0.218778185686841 no 2630 0.225232487106065 3763 935561 SGTC_829 1635-0120 117 µM -0.75667842296165 0.218179989379669 no 2631 0.224621272404373 3784 285054 SGTC_2836 9010338 19.48 µM -0.757132956635644 0.218046725828182 no 2632 0.224485105638723 3742 2994051 SGTC_2181 6316240 54.2555 µM -0.757160818557147 0.218038558590106 no 2633 0.224476760437264 3770 12779990 SGTC_760 0568-0725 82.9 µM -0.759807926815965 0.21726340948712 no 2634 0.223684702001941 3814 3916171 SGTC_1159 4092-0538 61.2 µM -0.760430874727416 0.217081224119948 no 2635 0.223498536957807 3799 717301 SGTC_3172 9105863 49.47 µM -0.760529059719712 0.217052517304153 no 2636 0.223469202878626 3740 2348785 SGTC_80 0159-0065 512.242 µM -0.761245750645841 0.216843041406954 no 2637 0.22325514823673 3702 1548079 SGTC_54 0159-0055 9 µM -0.763174446288991 0.216279899128515 no 2638 0.222679683181503 3785 3319099 SGTC_1139 k015-0024 46.9 µM -0.763313133420982 0.21623943779185 no 2639 0.222638335701676 3749 2766652 SGTC_314 1671-0008 2.74 µM -0.765292476084972 0.215662451419267 no 2640 0.222048701651266 3712 3913060 SGTC_2299 7976368 114.88 µM -0.76587292252653 0.215493418353235 no 2641 0.221875959407934 3822 2979718 SGTC_919 tnp00227 403.569 nM -0.769356581476682 0.214480550336114 no 2642 0.220840828169366 3779 1269246 A methoxyflavone. YNL221C POP1 SGTC_158 k038-0087 26.446 µM -0.770141535176538 0.214252709066637 no 2643 0.220607970039156 3727 X158 SGTC_2460 5552655 174.22 µM -0.771507223539753 0.213856639071705 no 2644 0.220203171220652 3767 5401989 SGTC_1701 st028638 40.4 µM -0.77211674057928 0.213680007729839 no 2645 0.220022644013636 3749 3490878 SGTC_1149 3909-7961 23.3 µM -0.772376163859474 0.21360485550355 no 2646 0.219945833602829 3810 735261 SGTC_2106 5357045 167.29 µM -0.772993532728004 0.213426072106774 no 2647 0.219763104049277 3823 668842 SGTC_2409 alverine citrate 63.97 µM -0.77418358069766 0.213081693206959 no 2648 0.219411118292355 3971 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1555 citronellol 128 µM -0.774339251671024 0.213036668759672 no 2649 0.219365098768832 3745 8842 A terpine precursor. SGTC_833 3852-0053 558 µM -0.774890490582013 0.212877279512615 no 2650 0.219202185873601 3852 3123681 SGTC_2397 5161689 200 µM -0.775775257955462 0.212621596968744 no 2651 0.21894084758933 3802 2259942 SGTC_3225 9130819 49.47 µM -0.77830982910805 0.211890143019476 no 2652 0.218193191174 3768 4547121 SGTC_986 1493-0483 84 µM -0.779379398769756 0.21158191724506 no 2653 0.217878127851337 3727 40079 SGTC_2426 5582046 32.21 µM -0.779442799613072 0.211563654801122 no 2654 0.217859460094566 3783 2251934 SGTC_1088 bifonazole 369 nM -0.779763184819413 0.211471382812121 no 2655 0.217765139921223 3726 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_888 0916-0002 6.97 µM -0.780308216417347 0.211314466082846 no 2656 0.217604738848105 3896 2802138 YIL048W NEO1 SGTC_2034 5197015 53.07 µM -0.783310608032058 0.210451289367338 no 2657 0.216722367676289 3792 780676 SGTC_2731 amoxapine 43.43 µM -0.783422165312239 0.210419256982717 no 2658 0.216689622089408 3856 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1010 4112-3296 15.2 µM -0.784019484590492 0.210247792346669 no 2659 0.216514338693339 3876 704384 SGTC_2197 6588183 93.1375 µM -0.786102857254528 0.209650388343606 no 2660 0.215903615261091 3753 884136 SGTC_533 1222-0222 6.71 µM -0.78768909131628 0.20919620820274 no 2661 0.215439293965066 3896 3982874 SGTC_3197 9113331 49.47 µM -0.793124224680773 0.207644386873289 no 2662 0.213852725127373 3804 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1651 st011928 86.1 µM -0.79509040448659 0.207084689260941 no 2663 0.213280457965831 3827 720198 SGTC_3159 9100096 49.47 µM -0.79518085943236 0.207058961625116 no 2664 0.213254152071845 3778 25236875 SGTC_2364 9055074 200 µM -0.796241556017512 0.206757414269758 no 2665 0.212945823990992 3837 6470630 SGTC_2739 tacrine 100.86 µM -0.79800421357107 0.206256880591417 no 2666 0.212434022469961 3852 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2419 paclitaxel 166.5 µM -0.798987930862217 0.205977851506692 no 2667 0.212148705135943 3761 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_768 0384-0033 77.3 µM -0.800138967487599 0.205651647097931 no 2668 0.211815143113983 3818 3965305 YMR134W ERG29 SGTC_811 0416-0114 265 µM -0.80286947197421 0.204879048163582 no 2669 0.211025091313673 3888 6612453 SGTC_1449 4112-4002 201 µM -0.803678316688126 0.204650516526083 no 2670 0.210791389983597 3865 2059539 SGTC_2721 ifenprodil 61.44 µM -0.803871832911577 0.204595862786902 no 2671 0.210735499415829 3822 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1992 st073643 23.3 µM -0.804336931001459 0.204464543175275 no 2672 0.210601207237118 3795 3161292 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.805656920044281 0.204092119961949 no 2673 0.210220347893219 3841 676296 Flavone; oxidizing agent. SGTC_1788 fluconazole 20 µM -0.805680052423684 0.204085596970898 no 2674 0.210213677065462 3889 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2285 7945142 200 µM -0.807022509131694 0.203707256681387 no 2675 0.209826757501993 3888 2970608 SGTC_2512 diallyl trisulfide 49.23 µM -0.80744969872382 0.203586950963506 no 2676 0.209703721830588 3864 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1152 3909-8331 15.9 µM -0.807727914262243 0.203508622311786 no 2677 0.209623615269907 3811 16001939 SGTC_2661 dactinomycin 12.96 µM -0.808299646371068 0.20334771360094 no 2678 0.209459053028158 3833 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_853 0419-0306 21 µM -0.809544604901242 0.202997594284834 no 2679 0.209100978393616 3857 762713 SGTC_2733 amorolfine 100 µM -0.810124341283334 0.202834678120284 no 2680 0.208934357853581 3876 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_743 1275-0778 158 µM -0.810872201143296 0.202624631698781 no 2681 0.208719532939681 3846 2849257 YMR203W TOM40 SGTC_215 1287-0124 461.5 µM -0.812135985058415 0.202269976732328 no 2682 0.208356803357356 3868 5560863 SGTC_1198 1612-1005 86.7 µM -0.812383225662703 0.202200637192913 no 2683 0.208285884199853 3918 6998509 SGTC_2922 7999257 32.47 µM -0.81381880890854 0.201798303661902 no 2684 0.207874379149016 3820 2988377 SGTC_1147 3809-1045 12.3 µM -0.813928374022526 0.201767616876149 no 2685 0.207842992413245 3827 325925 SGTC_43 0570-0105 72.5 µM -0.81403684912392 0.201737238132096 no 2686 0.207811920686834 3868 1114046 YDL195W SEC31 SGTC_3188 9110789 49.47 µM -0.814709027704604 0.201549053797649 no 2687 0.207619442300368 3834 849217 SGTC_916 4466-0038 42 nM -0.814915039170088 0.201491399517601 no 2688 0.207560471998075 3939 5722064 YGL116W CDC20 SGTC_653 0203-0016 55.2 µM -0.815117774122009 0.201434671850351 no 2689 0.207502449254456 3892 295302 SGTC_2224 6650123 117.647 µM -0.815347916790097 0.201370286777056 no 2690 0.207436594041935 3801 2908370 SGTC_2724 maprotiline 69.64 µM -0.817548308547434 0.200755324714883 no 2691 0.206807577009955 3794 4011 A tricyclic antidepressant. SGTC_1763 st044482 94.5 µM -0.81920047164502 0.200294322540764 no 2692 0.206336022934038 3900 88505 SGTC_1816 st051957 91.6 µM -0.819211022472131 0.200291380594612 no 2693 0.206333013606349 3843 674121 SGTC_272 doxorubicin 8.13 µM -0.821873976233573 0.199549684800533 no 2694 0.205574312731093 3847 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1225 1216-0074 20.6 µM -0.822655619770222 0.199332292739564 no 2695 0.205351929855614 3868 4241466 SGTC_3055 9094636 49.47 µM -0.823136505848808 0.199198618749913 no 2696 0.205215185536572 3853 25236176 SGTC_2188 6126565 140.678 µM -0.823770696419394 0.199022412626332 no 2697 0.205034930442199 3808 874518 SGTC_2653 dihydrofissinolide 100 µM -0.823828719125555 0.199006296049196 no 2698 0.205018443430405 3911 6857746 SGTC_1241 0364-0022 50.8 µM -0.824581847976009 0.198797175869798 no 2699 0.20480451519423 3895 4563895 SGTC_1476 4112-3294 3.34 µM -0.825522815638725 0.198536085007023 no 2700 0.204537417482205 3906 704369 SGTC_825 1988-2224 89.6 µM -0.8270843797429 0.198103253611226 no 2701 0.204094618525096 3856 1180859 SGTC_3147 9097027 49.47 µM -0.828447554438051 0.197725877591711 no 2702 0.203708542314267 3900 25236841 SGTC_2097 5376186 200 µM -0.829213383860001 0.197514059049785 no 2703 0.203491836455595 3812 742755 SGTC_560 2332-1943 155 µM -0.831022309376441 0.197014278616463 no 2704 0.202980513235224 3840 21177716 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.8329784308044 0.196474692317629 no 2705 0.202428446995702 3900 551469 SGTC_1228 0124-0032 52.5 µM -0.833951188882269 0.1962066956102 no 2706 0.20215424499157 3956 X1228 SGTC_1157 4092-0394 27.6 µM -0.834811797002415 0.19596978132482 no 2707 0.201911841301935 3985 3659885 SGTC_40 0327-0103 19.753 µM -0.837140659451872 0.195329546412845 no 2708 0.201256754021136 3769 409036 SGTC_1117 retinoic acid 1.10837 µM -0.83820271281696 0.195037996362675 no 2709 0.200958431861237 3868 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_164 4100-3994 89.624 µM -0.838856004895158 0.194858789085523 no 2710 0.200775059282107 3846 4615967 SGTC_1350 1495-0454 146 µM -0.838911376447527 0.194843604488834 no 2711 0.200759521656977 3913 1069057 SGTC_3079 9117512 49.47 µM -0.83908254692764 0.194796668786441 no 2712 0.200711494648216 3909 7185044 SGTC_3187 9109394 49.47 µM -0.839986064715004 0.194549034189447 no 2713 0.200458099954216 3889 17098090 SGTC_3353 9151644 39.2805 µM -0.841235009482477 0.194207041184589 no 2714 0.200108145611029 3962 4909158 SGTC_3022 9087993 49.47 µM -0.842502345335447 0.1938603867613 no 2715 0.199753413731629 3930 17173644 SGTC_12 0849-0099 9.267 µM -0.845798196450017 0.192960639818578 no 2716 0.198832665886255 3792 6071388 SGTC_154 3389-1638 511.116 µM -0.846496190413833 0.192770419541923 no 2717 0.198637999086185 3899 5238686 SGTC_3169 9102970 49.47 µM -0.84769688679958 0.192443468835225 no 2718 0.198303400298329 3970 17027839 SGTC_1126 isoteolin 1.0172 µM -0.848374823767015 0.192259015837932 no 2719 0.198114629537972 3854 133323 SGTC_844 0330-0132 15.3 µM -0.84962316115494 0.191919651381071 no 2720 0.197767315402713 3937 2828079 SGTC_1746 st038117 42 µM -0.850879576206719 0.19157846147489 no 2721 0.197418125642046 3977 2898218 SGTC_958 1222-0007 33 µM -0.852540920780221 0.191127880495341 no 2722 0.196956968526738 3997 7312461 SGTC_3087 9117406 49.47 µM -0.852654472868157 0.191097107248789 no 2723 0.196925472490426 3904 42546093 SGTC_1685 st024049 53.0905 µM -0.853366836816954 0.190904121988053 no 2724 0.196727953088474 3934 1941139 SGTC_623 k072-0108 16.9 µM -0.856910756796045 0.189945822922154 no 2725 0.195747103740942 3888 5382803 SGTC_2872 9044037 25.97 µM -0.858615879801776 0.189485802124424 no 2726 0.195276237054214 3905 6465195 SGTC_2213 7173844 200 µM -0.85861732716764 0.189485411934713 no 2727 0.195275837659267 3884 892728 SGTC_1448 4255-0083 152 µM -0.858663710869187 0.189472907795582 no 2728 0.195263038521149 3990 5399660 SGTC_1407 3909-7909 12.3 µM -0.859066072874188 0.189364460173662 no 2729 0.195152031971309 3891 4411780 SGTC_1146 3579-1023 7 µM -0.86245821977317 0.188451702843516 no 2730 0.194217707376507 3972 X1146 SGTC_2139 5578692 56.4705 µM -0.863022354649362 0.188300169264284 no 2731 0.19406258808758 3855 650991 YMR113W FOL3 SGTC_2601 securinine 100 µM -0.863229076399154 0.188244660080291 no 2732 0.194005765032023 3882 442872 A GABA receptor antagonist. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.868463367587144 0.186842507764371 no 2733 0.192570358972536 3914 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1474 0330-0125 5.35 µM -0.869444373197239 0.186580438804489 no 2734 0.192302060726298 3929 X1474 SGTC_739 1486-1183 203 µM -0.869514630057732 0.186561678901591 no 2735 0.192282854737891 3900 4346692 SGTC_2343 7990716 14.84 µM -0.8720917580911 0.185874344682097 no 2736 0.191579161027494 3923 6456862 SGTC_3036 9090181 49.47 µM -0.872999015310984 0.18563274840947 no 2737 0.191331807218508 3959 25236586 SGTC_237 nikkomycin 200 µM -0.873254863477231 0.185564653062815 no 2738 0.191262088397653 3925 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2905 7799065 20.05 µM -0.87424014656637 0.185302559564974 no 2739 0.190993743494279 3837 1296806 SGTC_3102 9121669 49.47 µM -0.874880585277389 0.18513232086299 no 2740 0.190819441921927 3942 41905072 SGTC_1652 st011932 78 µM -0.875157802795674 0.185058662213635 no 2741 0.190744024777135 3850 1551076 SGTC_1556 plumbagin 1.48 µM -0.876939357387337 0.184585725179 no 2742 0.190259788721087 3842 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2690 usnic acid 100 µM -0.878246512202284 0.184239202279228 no 2743 0.189904977836501 3938 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3241 9133421 49.47 µM -0.878847457088876 0.184080029487413 no 2744 0.18974199542522 3942 17018221 SGTC_2873 9040596 71.43 µM -0.878868034003166 0.184074580778612 no 2745 0.189736416278874 3934 6463863 SGTC_1185 1319-0113 81.3 µM -0.878999678829753 0.184039723976259 no 2746 0.189700724988457 4003 4672763 SGTC_1563 conessine 56.1 µM -0.880669004494621 0.183598077890729 no 2747 0.189248498906296 4013 441082 An anti-amoebic, histamine inhibitor. SGTC_85 0868-0259 160.055 µM -0.882860777257675 0.183019214094868 no 2748 0.188655748899107 3887 83173 SGTC_894 0960-0238 55.9 µM -0.883337358871314 0.182893496165657 no 2749 0.188527012297563 3898 6741907 YDL195W SEC31 SGTC_525 k781-2675 26.7 µM -0.883542445117115 0.182839412855253 no 2750 0.188471630053502 3920 3651118 YDL195W SEC31 SGTC_2226 7298446 200 µM -0.884162008672713 0.182676088338329 no 2751 0.18830438178079 3921 3283010 SGTC_320 4092-0846 5.34 µM -0.88448329337347 0.18259142964741 no 2752 0.188217688547043 3932 1359356 SGTC_2956 9076196 2.52 µM -0.885200535772113 0.182402524311814 no 2753 0.188024241713602 3967 16423868 SGTC_2457 5731572 11.68 µM -0.888895150393829 0.181431382359788 no 2754 0.187029716015369 4037 2865357 SGTC_3154 9100113 49.47 µM -0.890084497389904 0.181119448467015 no 2755 0.186710258250489 3992 25237525 SGTC_2228 7354201 200 µM -0.891396022756966 0.180775860217493 no 2756 0.18635837533716 3973 753451 SGTC_201 4262-0159 12.803 µM -0.893413212730268 0.180248202863727 no 2757 0.185817964774998 3985 1341029 SGTC_1587 estradiol valerate 56.1 µM -0.893635382040328 0.180190146876909 no 2758 0.185758504503686 4015 13791 A steroid. SGTC_2827 7993847 71.43 µM -0.89377253539524 0.180154312623041 no 2759 0.185721803365698 4033 2985692 SGTC_298 1391-0729 10 µM -0.894430569184559 0.179982449413184 no 2760 0.185545781371928 3913 3237558 SGTC_217 ketoconazole 989 nM -0.894697085210194 0.179912870892987 no 2761 0.185474518631139 3847 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2924 9010168 62.78 µM -0.895686096427714 0.179654820456401 no 2762 0.185210219075481 4077 2993929 SGTC_1793 st048256 72.231 µM -0.896315286312817 0.179490774846272 no 2763 0.185042198584965 3838 672022 SGTC_753 1322-0200 289 µM -0.896881499362601 0.179343229399136 no 2764 0.184891076571673 4045 5403907 SGTC_1339 1486-1321 22.7 µM -0.900125804288204 0.178499290001381 no 2765 0.184026652576377 3985 3469382 SGTC_128 0906-2981 13.371 µM -0.903682894468485 0.177576865901513 no 2766 0.183081785965279 3895 6740226 SGTC_227 fluconazole 33.516 µM -0.908581081843782 0.176311601859977 no 2767 0.181785648175934 3984 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2734 clemastine 41.6 µM -0.908952885951968 0.176215793632214 no 2768 0.181687497885976 4000 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3182 9108849 49.47 µM -0.90986644279041 0.175980523993413 no 2769 0.181446474470998 4027 17133045 SGTC_1743 st037606 46.3785 µM -0.909907585498178 0.175969933133758 no 2770 0.181435624515505 3948 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1873 rapamycin 2 nM -0.910406343114243 0.175841576217634 no 2771 0.181304126882227 3955 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_714 4296-0578 26.1 µM -0.911855200036766 0.175469044561968 no 2772 0.1809224738109 4013 1589775 SGTC_2229 7354935 190 µM -0.913810463781893 0.17496709877787 no 2773 0.180408223608537 3905 318112 SGTC_3084 9116877 49.47 µM -0.915751652272912 0.174469668540788 no 2774 0.179898583433366 3864 27241325 SGTC_1142 3253-1408 9.78 µM -0.916898543769004 0.174176199742742 no 2775 0.179597903567553 3950 256655 SGTC_228 caffeine 993.056 µM -0.918209318039157 0.17384118072387 no 2776 0.179254645641722 3982 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1628 st004252 77.7 µM -0.919254265232186 0.173574397876286 no 2777 0.178981296731835 4032 692968 SGTC_3161 9100388 49.47 µM -0.922307333506157 0.172796420234718 no 2778 0.178184144933464 4059 25236368 SGTC_1658 st012944 20 µM -0.922861332555354 0.172655489736485 no 2779 0.178039736805949 3885 24207260 SGTC_2464 5717415 7.67 µM -0.923099139330804 0.172595017122957 no 2780 0.177977771559635 3994 5285744 SGTC_2487 5918373 44.05 µM -0.92426082441183 0.172299802820596 no 2781 0.177675267109015 4056 2876279 SGTC_3110 9122132 49.47 µM -0.92706103242504 0.171589522468121 no 2782 0.176947423409512 4111 918317 SGTC_2647 atorvastatin 60.16 µM -0.927729731249885 0.171420182311928 no 2783 0.176773891041914 3979 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.929114327291698 0.171069889249234 no 2784 0.176414920103733 4017 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_650 1328-0195 38 µM -0.929646388039495 0.170935403479068 no 2785 0.176277100555084 3973 2780821 SGTC_1906 st060206 94.7 µM -0.930730235893105 0.170661655130597 no 2786 0.175996562571949 4034 5133468 SGTC_676 falcarinol 140 µM -0.933728359858234 0.169905879257026 no 2787 0.175222016059451 3978 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_539 4859-0462 2.54 µM -0.935462456911239 0.16946972400843 no 2788 0.174775011279204 4070 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3030 9087619 49.47 µM -0.937420750557099 0.168978044052898 no 2789 0.1742710856013 4049 25236973 SGTC_2009 4012297 12.05 µM -0.941759916166718 0.167891853113111 no 2790 0.17315778574199 4032 45595307 SGTC_547 1120-0019 610 nM -0.942595790411044 0.167683132398112 no 2791 0.172943846922003 3955 3676939 SGTC_884 0851-0618 334 µM -0.943205699878767 0.167530941373967 no 2792 0.172787849249067 4043 9642473 SGTC_2152 5568786 200 µM -0.943246256819007 0.167520824336062 no 2793 0.172777479106583 3997 5399883 SGTC_2389 9091542 195.52 µM -0.944950986315455 0.167095930964525 no 2794 0.17234194980614 4011 3626624 YOL127W RPL25 SGTC_972 1319-0219 195 µM -0.945843294606128 0.166873805886628 no 2795 0.172114259755543 3996 23903702 SGTC_1059 3448-6867 171 µM -0.947451642756714 0.166473916082086 no 2796 0.171704343174354 3939 3934407 SGTC_1720 st037298 9.481 µM -0.948196352955995 0.166288965630402 no 2797 0.171514751733156 4051 597396 SGTC_2516 gossypol 71.55 µM -0.949004508339252 0.166088408625802 no 2798 0.17130915956883 4058 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.949476665520498 0.165971307436731 no 2799 0.17118911722315 3988 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_171 k064-0041 9.68 µM -0.951830965774153 0.165388206541725 no 2800 0.170591357461982 4043 53325 SGTC_1741 st038134 10.228 µM -0.951967475826538 0.165354437141673 no 2801 0.17055673842754 4110 1272587 SGTC_2082 5219693 150 µM -0.953472050226007 0.164982536154575 no 2802 0.170175475463724 4028 2834649 SGTC_1978 st071761 42 µM -0.953609819635773 0.164948509373895 no 2803 0.170140591659704 4059 5147680 SGTC_642 0335-0876 158 µM -0.959167712857735 0.163579591344917 no 2804 0.168737131485417 4070 6812350 SGTC_2266 7929956 200 µM -0.959269742171211 0.163554530510946 no 2805 0.168711437129795 4005 2967153 SGTC_131 0141-0277 33.849 µM -0.962517388735101 0.162758133830307 no 2806 0.167894886360333 4019 1547771 SGTC_1213 1315-0166 115 µM -0.962854835923479 0.162675529006411 no 2807 0.167810188680358 4151 768401 SGTC_897 1000-0139 31.4 µM -0.963126468468497 0.162609054984278 no 2808 0.167742030159314 3984 6151020 SGTC_810 3825-7150 143 µM -0.963782841924185 0.16244849997196 no 2809 0.16757740535879 4116 22330411 YGL099W LSG1 SGTC_637 1181-0519 7.26 µM -0.963934351389627 0.162411454017191 no 2810 0.167539420110908 4043 6252091 YGR060W ERG25 SGTC_3035 9091303 49.47 µM -0.96498146715315 0.162155571477645 no 2811 0.167277047228862 4107 25237002 SGTC_1888 azatryptophan 97.5 µM -0.967585754549071 0.161520303623329 no 2812 0.166625647286672 4092 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_160 3453-0671 289.699 µM -0.969437171634818 0.161069672742975 no 2813 0.166163556745696 4096 5322268 SGTC_2715 st079500 56.4 µM -0.969593878359909 0.161031568364092 no 2814 0.166124482742907 4008 28246688 SGTC_3211 9128781 49.47 µM -0.971861288569616 0.160480889534309 no 2815 0.1655597802585 4087 17194361 SGTC_2794 7785382 27.27 µM -0.972526896375555 0.160319469315912 no 2816 0.165394245464863 4006 2205081 SGTC_1837 st055472 66.5 µM -0.97333127311827 0.160124537128607 no 2817 0.165194342173129 4160 676091 SGTC_802 4112-3352 742 µM -0.973555743295441 0.160070166824594 no 2818 0.165138584881569 4120 704594 SGTC_184 1494-0393 24.714 µM -0.975549846634494 0.159587692775379 no 2819 0.164643794274246 4031 3090647 SGTC_611 3453-1652 23.7 µM -0.975589491261539 0.159578110402202 no 2820 0.164633967125786 4068 1560575 SGTC_407 eburnamonine 100 µM -0.976709203873376 0.159307623847894 no 2821 0.164356568646804 3908 3195 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.983919708733484 0.157572993725835 no 2822 0.162577496190053 4059 2346 DNA damaging agent; causes G2/M arrest. SGTC_2371 9071574 200 µM -0.984084471711143 0.157533502299852 no 2823 0.162536990625863 4086 45596039 SGTC_2164 5685496 200 µM -0.986477942579562 0.156960553698552 no 2824 0.161949316980525 3980 759046 SGTC_360 0957-0399 1.01 µM -0.988219274560054 0.156544576528529 no 2825 0.161522635225234 4095 6752301 YPR165W RHO1 SGTC_2037 5169046 200 µM -0.988315854063315 0.15652152644906 no 2826 0.161498991645345 4142 5718022 SGTC_975 1335-0046 28.5 µM -0.989296798082145 0.156287536752149 no 2827 0.161258975094412 4094 16486740 SGTC_2813 7971799 71.43 µM -0.989626535440322 0.156208934550747 no 2828 0.161178347518414 4122 2234054 SGTC_2997 9067075 71.4286 µM -0.989654881663504 0.156202178644703 no 2829 0.161171417510875 4097 27209819 SGTC_1294 1000-1494 117 µM -0.991149822584841 0.155846154215785 no 2830 0.160806213904766 4079 712797 YDL207W GLE1 SGTC_3088 9117578 49.47 µM -0.992901672482461 0.155429627515785 no 2831 0.160378937331623 4119 678341 SGTC_1988 st071872 53.4 µM -0.994392083935929 0.155075840266688 no 2832 0.160016010259652 4111 16414116 SGTC_1413 3910-0535 34.4 µM -0.994550343679213 0.155038304524223 no 2833 0.159977504316487 4091 2876951 SGTC_817 1391-0715 46 µM -0.994807389862267 0.154977351589787 no 2834 0.15991497570648 4078 1353946 SGTC_2357 9067248 200 µM -0.995928312498 0.15471173406937 no 2835 0.159642488873444 4085 9150235 SGTC_1127 asiatic acid 681.4 nM -0.997123628080333 0.154428819752521 no 2836 0.159352252701725 4039 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_948 3448-0295 75.3 µM -0.997355817786646 0.154373903425365 no 2837 0.159295914509703 4066 678569 SGTC_1966 st070145 16.1 µM -0.999219876307614 0.153933493770719 no 2838 0.158844094657352 4043 3748532 SGTC_2458 5808907 16.39 µM -0.999744004868467 0.153809811039758 no 2839 0.158717205187502 4237 2731747 SGTC_1043 0916-0009 19.3 µM -1.00126416445051 0.153451459198338 no 2840 0.158349556491533 4130 3101130 SGTC_70 0141-0289 43.283 µM -1.00308555686178 0.153022825634253 no 2841 0.157909791360879 4078 352408 SGTC_1525 8-methoxypsoralen 92.5 µM -1.00424495403323 0.152750395137309 no 2842 0.157630279433982 4163 4114 Related to psoralen; DNA damaging agent. SGTC_1247 0448-0043 5.84 µM -1.00505115540546 0.152561146906608 no 2843 0.157436109026439 4130 3089013 YGL099W LSG1 SGTC_2465 5809242 33.21 µM -1.00649885982852 0.152221702494736 no 2844 0.15708782991272 4129 2731748 SGTC_845 0330-0138 4.51 µM -1.00724634323036 0.152046635906256 no 2845 0.156908203834071 4066 9039800 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.00810262170569 0.151846253037848 no 2846 0.156702599588951 4053 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2526 patulin 37.61 µM -1.00934064023973 0.151556847255274 no 2847 0.156405647969635 4133 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2334 9017922 200 µM -1.01168376461139 0.151010110436701 no 2848 0.15584464032326 4170 3163164 SGTC_1090 efavirenz 20.7 µM -1.01558731102337 0.150102188163581 no 2849 0.154912974922848 4124 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1143 3454-2408 5.08 µM -1.01570864041079 0.150074026707081 no 2850 0.154884076121494 4080 X1143 SGTC_918 glabranin 770.725 nM -1.01815853863739 0.149506140695009 no 2851 0.154301309805907 4113 124049 Also referred to as licorice root. SGTC_1878 temozolomide 1 mM -1.01848297825932 0.149431043325921 no 2852 0.154224243024472 4018 5394 DNA alkylating agent. SGTC_551 k048-0028 34.9 µM -1.01962361341545 0.149167222764426 no 2853 0.153953500791135 4108 6836383 SGTC_3156 9099931 49.47 µM -1.02005441944261 0.149067661462468 no 2854 0.153851326142234 4143 18111053 SGTC_2155 5570423 76 µM -1.02051769553907 0.14896064571769 no 2855 0.153741500631025 4061 797402 SGTC_2607 solasodine 47.35 µM -1.02239216239463 0.148528172148953 no 2856 0.153297664268575 4099 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_257 daunorubicin 18.5 µM -1.02337391259674 0.148301999876929 no 2857 0.153065544492697 4127 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2871 9038510 12.99 µM -1.02531152286083 0.147856296194625 no 2858 0.152608110249837 4031 4945164 SGTC_1490 4089-0339 670 nM -1.0255336272134 0.147805263433604 no 2859 0.152555733485399 4071 742542 SGTC_2162 5663267 200 µM -1.02553527559132 0.147804884731062 no 2860 0.152555344808649 4105 6456493 SGTC_754 3474-0146 171 µM -1.02797924487325 0.147244115531562 no 2861 0.151979795447133 4087 24762078 SGTC_2180 6301957 200 µM -1.02909808058066 0.146987874953918 no 2862 0.151716794020642 4139 845462 SGTC_3267 9137951 49.47 µM -1.03015880856037 0.146745218768925 no 2863 0.151467731281943 4157 16643986 SGTC_775 4577-0580 57.3 µM -1.03138551005915 0.14646492916977 no 2864 0.151180036542263 4177 2006902 SGTC_805 3852-0218 479 µM -1.03256967018461 0.146194700989878 no 2865 0.150902663965544 4090 6615355 SGTC_2304 7443016 91.4 µM -1.03405355653843 0.145856547567443 no 2866 0.150555563290503 4048 939854 SGTC_1546 5-methoxyflavanone 78.7 µM -1.03448946857186 0.145757310318427 no 2867 0.150453698825897 4106 147795 SGTC_486 niguldipine 82 µM -1.03769631701117 0.145028652729467 no 2868 0.149705730077952 4174 1236 A calcium channel blocker. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.038489412426 0.144848825047361 no 2869 0.14952113094841 4135 688669 SGTC_2271 7849410 118.62 µM -1.03856488512348 0.14483172007819 no 2870 0.149503572010278 4070 972430 SGTC_3146 9095609 49.47 µM -1.03954136280798 0.144610535924974 no 2871 0.149276515786135 4182 17173999 SGTC_1958 st076513 41.9 µM -1.04060376456469 0.144370147512863 no 2872 0.149029741663733 4088 732122 YGL099W LSG1 SGTC_876 0720-0963 56.8 µM -1.04247549682761 0.143947288365311 no 2873 0.148595640022582 4153 765861 SGTC_3126 9127922 49.47 µM -1.04458513789092 0.143471683563744 no 2874 0.148107375740214 4193 45595682 SGTC_1053 3366-3204 134 µM -1.04479358170652 0.143424748920899 no 2875 0.148059190966498 4174 3632071 YPR165W RHO1 SGTC_2490 carminic acid 95.39 µM -1.04484286632882 0.143413653171904 no 2876 0.148047799653836 4103 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2571 chrysanthemic acid 100 µM -1.04486588983868 0.14340846994668 no 2877 0.148042478357251 4155 2743 An insecticide. SGTC_2673 kobusone 100 µM -1.04564196075251 0.143233829027682 no 2878 0.147863184255382 4214 6710676 An epoxy ketone and protein crosslinker. SGTC_495 decylubiquinone 155 µM -1.04647590792214 0.143046324262314 no 2879 0.147670681228616 4203 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3247 9135149 49.47 µM -1.04715643469407 0.142893437492041 no 2880 0.147513717212359 4144 8934436 YOR116C RPO31 SGTC_3319 9138450 16.7555 µM -1.0480717876957 0.142687969019198 no 2881 0.147302766694762 4072 2029690 SGTC_2818 7996756 12.99 µM -1.04878650957817 0.142527674976652 no 2882 0.147138193879126 4152 2241621 SGTC_1357 1503-1303 39.5 µM -1.0493355609249 0.142404619387839 no 2883 0.147011852335289 4104 292895 SGTC_698 k064-0052 127 µM -1.05009437296029 0.142234669725058 no 2884 0.146837362792638 4221 5088751 SGTC_597 k018-0003 82.8 µM -1.0518857723421 0.141833998120074 no 2885 0.146425980150015 4210 6786234 SGTC_869 0564-0080 44.1 µM -1.05213067677924 0.141779281253779 no 2886 0.146369799696357 4146 6843321 SGTC_1211 1056-0033 32.3 µM -1.05486587889544 0.141169150297533 no 2887 0.145743334761822 4197 6741922 SGTC_1678 st019265 80.2 µM -1.05702949523189 0.140687783645316 no 2888 0.145249063212631 4161 5367020 SGTC_712 r015-0009 80.6 µM -1.05705455383059 0.140682215080175 no 2889 0.145243345267053 4188 6813872 YLR060W FRS1 SGTC_1101 ebselen 5.29 µM -1.05722460678658 0.140644429570071 no 2890 0.145204546079185 4198 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3053 9095903 49.47 µM -1.05761223094177 0.140558325814341 no 2891 0.145116132036652 4248 17174018 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.05850757449346 0.140359578101736 no 2892 0.144912049685772 4158 75037 A free radical scavenger. SGTC_287 k060-0039 29.6 µM -1.05916283536917 0.140214244761656 no 2893 0.144762813690591 4203 5861974 SGTC_142 0335-0849 62.6745 µM -1.06059449365336 0.139897066386264 no 2894 0.144437113018349 4161 3889043 YPR107C YTH1 SGTC_2240 6690706 185.951 µM -1.06089959034099 0.139829536473086 no 2895 0.144367767740095 4014 805876 SGTC_991 3996-0057 64.7 µM -1.06096550085262 0.139814950791881 no 2896 0.144352789919627 4222 715343 SGTC_2671 danthron 100 µM -1.06571634762735 0.138766334430904 no 2897 0.143275942733501 4143 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1042 0350-0096 82 µM -1.06577145966845 0.138754201504263 no 2898 0.143263482719254 4147 3122515 SGTC_1432 4049-0298 68.4 µM -1.06673726245038 0.138541697107026 no 2899 0.143045247832536 4188 741646 SGTC_1648 st011736 69.8 µM -1.06721645651593 0.138436342977379 no 2900 0.142937051516141 4151 2855514 SGTC_1410 3909-8106 77.9 µM -1.07038442308817 0.137741217381205 no 2901 0.142223153914173 4219 1039210 SGTC_97 0535-0701 19.132 µM -1.07277630702302 0.137217963011802 no 2902 0.141685746842884 4061 2832013 YGL099W LSG1 SGTC_2648 atorvastatin 78.68 µM -1.07325192434658 0.137114077850615 no 2903 0.141579049590109 4171 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_772 k072-0172 35.3 µM -1.07515539988725 0.136698855333491 no 2904 0.141152579829881 4202 5861980 SGTC_1833 st055984 71 µM -1.07622610631756 0.136465670536793 no 2905 0.140913073438944 4171 676288 SGTC_777 1315-0167 517 µM -1.07683100855913 0.136334051683881 no 2906 0.140777884754856 4194 4221767 SGTC_835 0312-0010 67.2 µM -1.07747167845996 0.136194744989184 no 2907 0.140634798402577 4156 1626196 SGTC_183 3914-0051 30.55 µM -1.07947942969038 0.135758812471936 no 2908 0.140187029472748 4200 1596232 SGTC_883 0850-0245 24.6 µM -1.08184146608507 0.135247180575669 no 2909 0.139661488892733 4242 6823229 YPR165W RHO1 SGTC_1605 st000082 49.1 µM -1.08262173543829 0.135078460167717 no 2910 0.139488177828859 4141 1114022 SGTC_1560 lithocholic acid 53.1 µM -1.08591883439157 0.134367110717042 no 2911 0.138757451670844 4082 9903 A bile acid which acts as a detergent. SGTC_3026 9090633 49.47 µM -1.08621730450364 0.134302842963512 no 2912 0.138691431564153 4179 25236842 SGTC_2893 9048488 25.97 µM -1.08790033365333 0.133940841690691 no 2913 0.138319554411737 4236 6467338 SGTC_402 epigallocatechin gallate 10 µM -1.08824951449814 0.133865820755586 no 2914 0.138242485659052 4122 65064 An antioxidant. SGTC_1714 st033236 13.627 µM -1.08825204229593 0.133865277767664 no 2915 0.138241927847962 4224 2916566 SGTC_2482 5981709 142.65 µM -1.08825360587644 0.133864941900841 no 2916 0.138241582812214 4128 877755 SGTC_2568 diosmetin 100 µM -1.09032694532662 0.133420085191109 no 2917 0.137784574904052 4240 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_645 0845-0943 5.41 µM -1.09057508932695 0.13336691151026 no 2918 0.137729947865004 4191 1885106 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.09148928711849 0.133171137909174 no 2919 0.137528821617943 4189 1377 SGTC_890 0929-0006 47.2 µM -1.09470416557864 0.132484249292025 no 2920 0.136823131541365 4155 1378169 SGTC_1022 4477-0945 21.3 µM -1.09958214110797 0.131446693734164 no 2921 0.13575711333733 4140 4648966 SGTC_1084 voriconazole 435 nM -1.10119252571314 0.13110539653863 no 2922 0.135406437006915 4196 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2561 acetosyringone 100 µM -1.10307394358337 0.130707433834366 no 2923 0.13499752760395 4175 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_393 acivicin 6.25 µM -1.10642697332777 0.130000263755661 no 2924 0.134270877990033 4056 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_693 4161-2696 114 µM -1.10692669039875 0.129895098215031 no 2925 0.134162812574378 4232 805759 SGTC_1018 4259-0013 28.1 µM -1.10779772833468 0.129711928977768 no 2926 0.133974590695648 4258 6801262 SGTC_2962 9082311 13.18 µM -1.10847675977631 0.129569260630327 no 2927 0.133827985265752 4180 16459453 SGTC_2720 fluspirilene 36.88 µM -1.10889212940905 0.129482042725468 no 2928 0.133738359783947 4194 3396 An atypical antipsychotic. SGTC_626 0214-0009 33 µM -1.1091265570878 0.129432836358741 no 2929 0.133687794879898 4262 3437874 SGTC_339 3091-4833 71.4 µM -1.10956360594617 0.129341134408521 no 2930 0.133593560676735 4066 3240077 SGTC_1396 3511-0007 98.6 µM -1.11053206648546 0.129138091683164 no 2931 0.133384909026859 4222 X1396 SGTC_2852 9023854 51.95 µM -1.11078549329665 0.129084995949387 no 2932 0.133330346077304 4252 19798528 SGTC_2135 5326629 150.42 µM -1.11134516781613 0.128967791547007 no 2933 0.133209902213357 4160 5020077 SGTC_324 1315-0088 19.6 µM -1.11348939398144 0.128519440901978 no 2934 0.132749150454904 4168 6787421 SGTC_1693 xanthone 101.9 µM -1.11373428189202 0.128468304560954 no 2935 0.132696598809786 4250 7020 An insecticide. SGTC_2551 apiole 73.87 µM -1.11443986602012 0.128321046779731 no 2936 0.132545264331081 4103 10659 A possible DNA adduct former. SGTC_860 0443-0016 25.1 µM -1.11877568210743 0.127418720347027 no 2937 0.131617924281335 4235 5337942 SGTC_690 glyoxal 20.3 µM -1.11884193239063 0.127404967318241 no 2938 0.131603789554963 4014 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1591 genipin 88.4 µM -1.12769369792012 0.125576688900749 no 2939 0.12972465004806 4250 442424 A DNA cross-linking agent. SGTC_122 0236-0016 402.397 µM -1.12821759843564 0.125469057208749 no 2940 0.129614016728208 4215 6808838 SGTC_292 k038-0015 474 µM -1.13141589029684 0.12481338684177 no 2941 0.128940043223509 4218 46368540 SGTC_1619 st003326 88.7 µM -1.1359217685503 0.123893721354462 no 2942 0.127994653448739 4221 2849032 SGTC_2495 cafestol 54.53 µM -1.13718944526283 0.123635841167936 no 2943 0.127729549155899 4240 16667697 An anti-infammatory. SGTC_2414 st077232 92.9 µM -1.1377165008744 0.123528734312446 no 2944 0.127619440472931 4175 729801 SGTC_534 k292-0788 63.4 µM -1.13938607677718 0.123189876541737 no 2945 0.1272710803066 4287 4146317 SGTC_2842 9000675 19.48 µM -1.1417411548707 0.12271299736105 no 2946 0.126780814345264 4290 2989072 SGTC_1 0258-0098 57.368 µM -1.14187471071431 0.122685992522127 no 2947 0.126753050948668 4179 6790032 YDR047W HEM12 SGTC_987 1497-1013 404 µM -1.14862902408835 0.121325711074958 no 2948 0.125354491896141 4254 1676435 SGTC_2792 7535235 81.82 µM -1.15127698963427 0.120795330089141 no 2949 0.124809150230537 4237 1281891 SGTC_1614 st002383 48.6 µM -1.15246076722212 0.120558750966412 no 2950 0.124565891288998 4265 1947235 SGTC_1005 4092-0690 4.4 µM -1.15446332474698 0.12015928102482 no 2951 0.12415513314605 4260 1529343 SGTC_394 menadione 8.33 µM -1.15505572070117 0.120041288916467 no 2952 0.124033804621319 4231 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1052 3253-3998 198 µM -1.15567429444235 0.119918169952962 no 2953 0.123907203200526 4178 5450317 SGTC_1318 1280-3875 124 µM -1.15921464755525 0.119215221980901 no 2954 0.123184351168391 4250 373245 SGTC_2113 5491891 107.031 µM -1.16073282467764 0.118914676024699 no 2955 0.122875284317847 4251 789979 SGTC_1810 st050138 53 µM -1.16207978597885 0.118648473130494 no 2956 0.122601528745501 4256 3444541 SGTC_248 streptozotocin 5.23457 mM -1.16270780584164 0.11852450022856 no 2957 0.122474036747889 4276 5300 DNA alkylating agent. SGTC_2635 hydroquinidine 100 µM -1.16375297286021 0.118318384298205 no 2958 0.12226206754568 4169 442912 An experimental heart treatment. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.16422747827212 0.118224891434825 no 2959 0.122165918661113 4115 4000243 SGTC_1112 tnp00069 1.16933 µM -1.16433504480307 0.118203704625587 no 2960 0.12214412987176 4263 145826 SGTC_2621 lithochol-11-enic acid 100 µM -1.16735900997389 0.11760918860248 no 2961 0.121532708614106 4213 6708711 SGTC_989 1501-0895 10.3 µM -1.16891405287879 0.117304290325511 no 2962 0.121219130517413 4225 2830112 SGTC_2247 cerulenin 830 nM -1.1712831141459 0.116840863778129 no 2963 0.120742498247297 4320 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3333 9141820 12.094 µM -1.17429640351082 0.11625329298246 no 2964 0.12013816168025 4240 1939433 SGTC_222 nsc-310342 10.666 µM -1.17486988178233 0.116141706550212 no 2965 0.120023388396042 4277 432556 SGTC_2603 homopterocarpin 100 µM -1.17877154049119 0.115384546077793 no 2966 0.119244579832294 4252 101795 A weak amylase inhibitor. SGTC_2597 laccaic acid a 100 µM -1.17882918992392 0.115373384923006 no 2967 0.119233099254466 4259 5491415 A textile dye. SGTC_3306 9127676 59.7925 µM -1.17886315184703 0.115366810121534 no 2968 0.119226336283346 4239 41905287 SGTC_1974 st069448 26.9 µM -1.17977371963375 0.115190629552424 no 2969 0.119045112282426 4268 6323587 YNR016C ACC1 SGTC_2222 6885208 172.143 µM -1.17991789984555 0.115162750496169 no 2970 0.119016434938874 4237 609514 SGTC_1036 k216-0215 33.5 µM -1.18016223901092 0.11511551540147 no 2971 0.118967847187628 4232 622330 SGTC_1150 3909-7983 10.9 µM -1.18113199126428 0.114928180925799 no 2972 0.118775146468559 4249 23965914 SGTC_1703 st026983 48.3 µM -1.18507647515587 0.114168429728423 no 2973 0.117993605703269 4299 1104023 SGTC_2336 9001819 198.65 µM -1.18941219449963 0.113337456872022 no 2974 0.117138752257042 4344 2989602 SGTC_482 fipronil 114 µM -1.19007792392382 0.11321024791391 no 2975 0.117007883084732 4374 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_947 3447-0010 211 µM -1.19288535209128 0.112674919321767 no 2976 0.116457138332031 4242 748350 SGTC_2438 5259590 200 µM -1.19404124154444 0.112455037130934 no 2977 0.116230917968089 4295 1201127 SGTC_2146 5545642 200 µM -1.19436703651346 0.112393117317892 no 2978 0.116167212655454 4239 825326 SGTC_1491 4138-0063 26.5 µM -1.19580020168626 0.112121022645115 no 2979 0.115887268605964 4267 23883227 SGTC_2677 mitomycin C 100 µM -1.19633817069753 0.112019007772974 no 2980 0.115782309408239 4326 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_726 3448-4391 34.2 µM -1.19745739225108 0.111806982875404 no 2981 0.115564162654 4388 1356692 SGTC_2242 6630449 61.2675 µM -1.19756645282462 0.111786337840031 no 2982 0.115542921351592 4330 691249 YDR170C SEC7 SGTC_3104 9120930 49.47 µM -1.19899035879725 0.111517044311063 no 2983 0.115265847247548 4304 17014836 SGTC_2895 9054447 58.44 µM -1.20036542512225 0.111257428405935 no 2984 0.114998725316574 4363 2697450 SGTC_213 1246-0773 967 nM -1.20076569489211 0.111181937862502 no 2985 0.114921051254341 4302 6251622 SGTC_1320 1313-0481 95.3 µM -1.20394905658898 0.110582864004452 no 2986 0.114304634625612 4257 6813365 YLR208W SEC13 SGTC_2386 9075165 157.42 µM -1.20480316247151 0.110422525009582 no 2987 0.114139649430346 4272 16452277 SGTC_555 4296-0685 37 µM -1.20835235358439 0.109758030469997 no 2988 0.113455879320824 4268 2908540 YHR072W ERG7 SGTC_1529 apigenin 74 µM -1.20956739964487 0.109531205288543 no 2989 0.113222466938948 4308 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1293 1000-1278 195 µM -1.21098202110554 0.109267547637784 no 2990 0.112951147647768 4326 678847 SGTC_471 1-acyl-paf 4 µM -1.21193714924308 0.109089788570174 no 2991 0.112768220160802 4238 16759367 SGTC_459 nigericin 15.3 µM -1.21349600352616 0.108800116480083 no 2992 0.112470120708428 4368 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3051 9093778 49.47 µM -1.21446708242805 0.108619946802905 no 2993 0.112284706253654 4371 17217378 SGTC_2947 9072639 7.68 µM -1.21838670774139 0.107894898217143 no 2994 0.111538526951146 4294 16488146 SGTC_707 0865-0008 204 µM -1.21998517560626 0.107600217907216 no 2995 0.111235247335651 4335 723043 SGTC_2769 toremifene 3.73 µM -1.22002155442785 0.107593518164638 no 2996 0.111228352007226 4335 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3281 9140613 49.47 µM -1.22261156574485 0.107117298356669 no 2997 0.11073822132282 4309 16013766 SGTC_1453 4237-0541 195 µM -1.22328444592642 0.106993826459213 no 2998 0.110611139920897 4306 739892 SGTC_191 3914-0123 66.505 µM -1.22450743061668 0.106769674634269 no 2999 0.110380432465427 4329 3144412 SGTC_1381 2324-0066 62.1 µM -1.22489961929506 0.106697865079106 no 3000 0.110306521946755 4332 10885928 SGTC_484 loperamide 105 µM -1.22493176458203 0.106691980838702 no 3001 0.110300465531484 4370 3955 An opioid-receptor agonist. SGTC_1353 1498-1206 8.11 µM -1.23114886856448 0.105558330121131 no 3002 0.109133595501383 4343 6756808 SGTC_526 4469-0568 170 µM -1.23160933896161 0.105474713970542 no 3003 0.109047525340127 4275 2901964 SGTC_2470 5664817 21.68 µM -1.23329617371438 0.105168813293341 no 3004 0.108732642461924 4345 2859561 SGTC_1842 st055362 61.2 µM -1.23443010903812 0.104963539862513 no 3005 0.108521337624521 4268 676032 SGTC_603 3794-0023 45.9 µM -1.23504772116103 0.104851857194096 no 3006 0.10840637213313 4349 3802260 SGTC_472 calcifediol 10 µM -1.23709778604678 0.104481761242477 no 3007 0.108025390808826 4368 5283731 A vitamin D metabolite. SGTC_2322 7413319 38.22 µM -1.24308623190005 0.103406096097102 no 3008 0.106918029377518 4298 1840400 SGTC_453 enantio-paf c16 10 µM -1.24491702123456 0.103078853505569 no 3009 0.106581126731978 4038 13871343 A lipid and platelet activating factor SGTC_279 1273-0055 2.93 µM -1.24712492570468 0.102685205187077 no 3010 0.106175847380128 4353 2847562 SGTC_736 0958-0254 92.6 µM -1.24901246152758 0.102349542804543 no 3011 0.105830258010405 4399 6812352 SGTC_3206 9114350 49.47 µM -1.25265195915677 0.101704581301113 no 3012 0.105166198276369 4192 17087243 SGTC_953 1188-0045 9.7 µM -1.25372995900493 0.101514116367621 no 3013 0.10497008737646 4325 6144426 SGTC_2234 tolnaftate 200 µM -1.25568341425461 0.101169634928451 no 3014 0.10461538745873 4410 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3221 9128209 49.47 µM -1.26010101272299 0.10039375809759 no 3015 0.103816462498407 4364 16460723 SGTC_664 1222-0054 14.9 µM -1.26080821581709 0.100269954058498 no 3016 0.103688976511977 4302 6813991 SGTC_1329 1447-1697 50.6 µM -1.26187080301516 0.100084145502678 no 3017 0.103497639796961 4339 2840515 SGTC_208 k072-0098 12.366 µM -1.26327194631099 0.0998395200512431 no 3018 0.10324573226096 4314 5948901 SGTC_806 3966-4455 5.86 µM -1.27344494743281 0.0980765030784223 no 3019 0.101430098150444 4323 714982 SGTC_3098 9119039 49.47 µM -1.27614830185744 0.0976118616098006 no 3020 0.100951549872375 4343 17161528 SGTC_1731 st035964 63 µM -1.27984124166483 0.0969797457355132 no 3021 0.100300488036335 4260 6739575 SGTC_1934 st074720 32.6 µM -1.2866169761277 0.0958277758098258 no 3022 0.0991139118574038 4288 17250992 SGTC_640 3381-0960 37.1 µM -1.28734777071002 0.0957041343664306 no 3023 0.0989865500290523 4401 1745025 SGTC_2723 salbutamol 83.58 µM -1.28811167313933 0.0955750169913788 no 3024 0.0988535462375811 4354 9884233 β2-adrenoceptor agonist SGTC_2907 7721985 69.9 µM -1.29346418117191 0.0946739121385701 no 3025 0.0979252823567533 4369 3267881 SGTC_1097 itavastatin 7.23 µM -1.29677109461007 0.0941203254487627 no 3026 0.0973549795471215 4379 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_688 0527-0193 473 µM -1.29706428296797 0.0940713603783025 no 3027 0.097304534781598 4407 4007154 SGTC_1277 0873-0036 22 µM -1.29914682918321 0.0937240973787206 no 3028 0.0969467723600205 4444 5965735 SGTC_76 0433-0009 400.328 µM -1.29915730559329 0.0937223528409911 no 3029 0.0969449750529181 4429 2841569 SGTC_113 0099-0221 2.5 µM -1.29987289320785 0.0936032495225784 no 3030 0.0968222684972868 4334 89219 SGTC_2076 5212012 200 µM -1.30386596160684 0.0929406894622717 no 3031 0.0961396438375118 4344 604802 SGTC_2087 5276107 200 µM -1.30450302179801 0.0928353051215315 no 3032 0.0960310649451625 4326 144405 SGTC_3097 9117246 49.47 µM -1.30631092838695 0.0925367171815184 no 3033 0.0957234211047472 4394 16423892 SGTC_877 0771-0151 33.1 µM -1.30707215353915 0.0924112084964493 no 3034 0.0955941037794308 4384 6166523 SGTC_2258 7960471 200 µM -1.30922363976456 0.0920571586137205 no 3035 0.0952293034015139 4377 2974708 SGTC_706 4262-0057 46.9 µM -1.30960236843248 0.0919949388909124 no 3036 0.0951651934054668 4370 883298 SGTC_846 0335-0850 148 µM -1.3121538284746 0.091576581733225 no 3037 0.094734118440769 4359 6819598 SGTC_162 k030-0015 37.8 µM -1.31409358104611 0.0912594694472607 no 3038 0.0944073570045452 4431 1809920 YMR134W ERG29 SGTC_847 0342-0274 5.54 µM -1.31539353461941 0.091047408124143 no 3039 0.0941888386449471 4368 18097 SGTC_2704 st078022 71.1 µM -1.31881416615885 0.0904911473323761 no 3040 0.0936156235544737 4402 54697681 SGTC_1798 st045719 60.953 µM -1.32365910054611 0.0897075908222361 no 3041 0.0928081437399312 4331 3980186 SGTC_1267 0828-0272 9.49 µM -1.32706160375668 0.0891603369800774 no 3042 0.0922441526359213 4441 745334 SGTC_2231 micatex 6.853 µM -1.33044938851651 0.0886179225563812 no 3043 0.0916851256360751 4412 20737 An antifungal of unknown mechanism. SGTC_3014 9081533 49.47 µM -1.3331150173816 0.088192862483281 no 3044 0.0912470309529847 4422 21367265 SGTC_3288 9119690 36.221 µM -1.33500036530143 0.087893144527209 no 3045 0.0909381134452295 4382 17595618 YKL019W RAM2 SGTC_3185 9108267 49.47 µM -1.33508816237609 0.0878792057649921 no 3046 0.0909237466730072 4395 4910486 SGTC_2166 5933061 31.504 µM -1.33682694819045 0.0876034937157603 no 3047 0.0906395653170456 4472 2877375 SGTC_1024 4507-0395 26 µM -1.33938974288511 0.0871982994886046 no 3048 0.0902219134086468 4450 4201836 SGTC_3223 9129970 49.47 µM -1.33994913405791 0.0871100425289104 no 3049 0.0901309412622732 4408 17248386 SGTC_2702 st077768 96.8 µM -1.34137444138666 0.0868854687310575 no 3050 0.0898994557571955 4370 6484119 SGTC_1347 1493-0251 600 nM -1.34169548147754 0.0868349448581913 no 3051 0.0898473763584569 4430 3986378 SGTC_2203 7227154 166.4 µM -1.34177389632703 0.0868226076115226 no 3052 0.0898346592425476 4416 896304 SGTC_3302 9125395 16.351 µM -1.34288180915987 0.0866484362685449 no 3053 0.0896551237947557 4343 17599668 SGTC_1384 3089-0840 101 µM -1.34504947151202 0.0863084206937719 no 3054 0.0893046295058362 4402 1069836 SGTC_2066 5222451 176 µM -1.34962927256003 0.0855933241787029 no 3055 0.0885674648178381 4346 2281147 SGTC_490 phenamil 164 µM -1.3515282299389 0.0852981228997542 no 3056 0.0882631415931955 4405 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_635 k038-0028 24.7 µM -1.35179574868344 0.0852565973030156 no 3057 0.0882203322644775 4395 4035102 SGTC_2992 9074591 71.4286 µM -1.35613191059294 0.0845856273954366 no 3058 0.0875286006937778 4356 17741321 SGTC_2161 5662504 8.5105 µM -1.35693625886526 0.0844616006935099 no 3059 0.0874007323106813 4364 2859334 SGTC_2301 7769476 200 µM -1.35733290620058 0.0844004898028369 no 3060 0.0873377280788199 4391 977820 SGTC_1113 artemisinin 1.17947 µM -1.3609115465583 0.0838506329801256 no 3061 0.0867708220677569 4448 2240 An anti-malaria and mitochondrial poison. SGTC_2016 5121758 140 µM -1.36555873768001 0.0831406147040752 no 3062 0.0860387525572983 4349 2795203 SGTC_586 0957-0265 8.15 µM -1.36686962015462 0.0829411521607759 no 3063 0.0858330879398006 4291 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2728 chlorpromazine 9.18 µM -1.36752551719249 0.0828414867486886 no 3064 0.0857303223354871 4499 2726 A thorazine and dopamine antagonist. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.37020000560827 0.082436023314151 no 3065 0.0853122382841583 4425 5024745 SGTC_2002 4023503 131 µM -1.37084756967391 0.0823380749973978 no 3066 0.0852112391961033 4404 4736863 YCR052W RSC6 SGTC_1915 st067105 30.6 µM -1.37268913495503 0.0820600051617407 no 3067 0.084924504159933 4358 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2896 9052656 71.43 µM -1.37590494824072 0.081576126084958 no 3068 0.0844255315316348 4140 6469436 SGTC_1863 st057641 20.1 µM -1.377426651769 0.0813479086789202 no 3069 0.0841901887917327 4461 3921635 SGTC_1468 k284-1086 134 µM -1.37862830111062 0.0811680319591088 no 3070 0.0840046930360437 4415 15996457 SGTC_1766 st045414 44.774 µM -1.38159812653851 0.0807247619098632 no 3071 0.083547564775407 4426 253960 SGTC_1498 4478-3555 97.6 µM -1.3827867237376 0.0805478674400847 no 3072 0.0833651354870668 4409 3437919 SGTC_110 0850-0284 111.64 µM -1.38286691935949 0.0805359427788467 no 3073 0.0833528376256183 4330 3906265 SGTC_3184 9108758 49.47 µM -1.38570490689166 0.080114807280408 no 3074 0.0829185146268112 4446 902885 SGTC_3204 9114183 49.47 µM -1.38724536951951 0.0798869126367067 no 3075 0.0826834776237587 4395 17027248 SGTC_1070 indatraline 8.81 µM -1.38885925191346 0.0796486825500993 no 3076 0.0824377767246988 4483 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2317 5986382 200 µM -1.38901415125495 0.0796258456863783 no 3077 0.0824142234613155 4449 877883 SGTC_1953 st076800 12.1 µM -1.39598428854706 0.0786033550503924 no 3078 0.081359613228452 4420 297591 SGTC_1072 oxiconazole 14.9 nM -1.39774871514729 0.078346106186176 no 3079 0.0810942698851732 4425 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1813 st051246 8.6015 µM -1.39885943111695 0.0781844943902116 no 3080 0.0809275701035908 4380 5291959 SGTC_720 r052-1644 49.9 µM -1.39941679409966 0.0781034920987258 no 3081 0.0808440168285939 4448 1422863 YOR257W CDC31 SGTC_3290 9121031 71.43 µM -1.40025891859246 0.0779812258260853 no 3082 0.0807178990349882 4450 17014854 SGTC_1486 3970-0793 4.53 µM -1.40399278397865 0.0774408627387148 no 3083 0.0801604991832164 4468 2844330 SGTC_3257 9139206 32.98 µM -1.40686198730095 0.0770275689233898 no 3084 0.0797341586437569 4447 4910041 SGTC_1025 k007-0731 70 µM -1.40768736205184 0.0769089890138374 no 3085 0.0796118328389596 4411 6256118 SGTC_2687 chenodiol 100 µM -1.41649805585654 0.0756518081069897 no 3086 0.0783148664878598 4484 5702181 A cholesterol synthesis inhibitor. SGTC_1814 st052110 31.539 µM -1.42126338521972 0.074978408218281 no 3087 0.0776201018685373 4381 674163 SGTC_1715 st032160 10.2275 µM -1.42721707965218 0.0741435136714787 no 3088 0.0767586664537875 4366 5289825 SGTC_1718 roemerine 11.9335 µM -1.43104689449127 0.073610218707085 no 3089 0.0762083878393047 4080 235224 An aporphine alkaloid with mutagenic activity. SGTC_1993 st073995 70.8 µM -1.43173980932003 0.0735140456224335 no 3090 0.0761091494316548 4467 3098394 SGTC_3017 9080681 49.47 µM -1.43579451774524 0.0729531976729126 no 3091 0.0755304101361629 4482 16451914 SGTC_1082 camptothecin 424.86 nM -1.43790404095025 0.0726627062475525 no 3092 0.0752306414982555 4324 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1477 0139-0234 16 µM -1.44195995764715 0.0721066771040404 no 3093 0.0746568350575933 4465 620880 SGTC_1657 st012939 43.4 µM -1.44289324344187 0.0719791949470669 no 3094 0.0745252733857594 4464 24207257 SGTC_2701 st077767 14.721 µM -1.44336178098464 0.0719152602592412 no 3095 0.0744592922287837 4434 5721188 SGTC_1385 3091-4834 14.1 µM -1.44554230077355 0.0716182883667355 no 3096 0.0741528101155723 4450 4072814 SGTC_2990 9074105 71.4286 µM -1.44587773398211 0.0715726882769409 no 3097 0.0741057490699948 4384 6502001 SGTC_589 1227-0070 34.1 µM -1.44636508722323 0.0715064752901357 no 3098 0.0740374144095272 4508 2841384 SGTC_19 0279-0214 38.434 µM -1.44951031627618 0.0710802869098671 no 3099 0.0735975607313537 4530 3566274 YBR002C RER2 SGTC_1023 4482-3888 16 µM -1.45051459866913 0.0709446151724932 no 3100 0.0734575355912997 4474 3303168 SGTC_2216 7189485 200 µM -1.45335753743102 0.0705616319297174 no 3101 0.073062254854483 4478 731273 SGTC_5 0352-0601 109.883 µM -1.45410457504365 0.0704612597405754 no 3102 0.0729586576820646 4377 762456 SGTC_1330 1469-0054 61.8 µM -1.4608887431588 0.0695547552413072 no 3103 0.0720229881730194 4450 7102664 SGTC_1265 0819-1001 68.8 µM -1.46190685867948 0.0694194925005535 no 3104 0.0718833676184776 4409 3106768 SGTC_3340 9146634 11.102 µM -1.46260735136142 0.0693265455639838 no 3105 0.0717874252686656 4454 4907387 SGTC_657 3534-0529 86.7 µM -1.46768058842807 0.0686562469346806 no 3106 0.0710955029882755 4505 1049549 SGTC_1829 berberine 14.4 µM -1.46800011304131 0.0686141978206522 no 3107 0.0710520961005575 4438 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2404 5161160 200 µM -1.46988725306242 0.0683662570799836 no 3108 0.0707961462286996 4417 2831543 SGTC_3324 9138759 60.749 µM -1.47569465506119 0.0676075912224648 no 3109 0.070012940737788 4502 45595710 SGTC_2984 9022109 38.96 µM -1.47728939808122 0.0674004001825254 no 3110 0.0697990393453472 4491 6459207 SGTC_931 2812-0076 566 µM -1.47820095355341 0.0672821903684329 no 3111 0.0696769993824459 4408 3450959 SGTC_2147 5545932 89.7195 µM -1.48031668648603 0.0670084414985551 no 3112 0.0693943760778511 4532 797404 SGTC_1194 1488-0194 225 µM -1.48372303798299 0.0665695140596329 no 3113 0.0689412059267654 4461 1391452 SGTC_2136 5328288 199.296 µM -1.48587554870549 0.0662933005994668 no 3114 0.068656021111047 4458 262395 SGTC_10 0279-0212 42.575 µM -1.48617681417054 0.0662547126620333 no 3115 0.0686161793201018 4492 39851 YBR002C RER2 SGTC_382 3229-0966 23.2 µM -1.49419724392212 0.0652337898633694 no 3116 0.067562036384795 4530 5722370 SGTC_3008 9078912 71.4286 µM -1.49735641001089 0.0648350256306762 no 3117 0.0671502720432785 4519 16648731 SGTC_1986 st071812 45 µM -1.49840649187208 0.0647028994648968 no 3118 0.0670138353793323 4431 11838594 SGTC_1883 5-benzylidenerhodanine 20 µM -1.50001512596173 0.064500899315264 no 3119 0.0668052422128869 4481 1273210 SGTC_604 1000-0114 314 µM -1.50279566635412 0.0641528957329249 no 3120 0.0664458719023336 4499 1572745 SGTC_1512 0259-0544 12.2 µM -1.50890993505551 0.0633927880990827 no 3121 0.0656609002836201 4469 18476 SGTC_3321 9137793 26.8275 µM -1.51070177092207 0.0631713658277115 no 3122 0.0654322255130768 4463 4904192 SGTC_513 4245-1575 41.7 µM -1.51497827359428 0.0626453402498973 no 3123 0.0648889531388278 4332 719745 SGTC_3229 9132204 49.47 µM -1.52213293268936 0.0617729323160701 no 3124 0.0639878878319914 4607 17682924 SGTC_1679 SEC14.276 6.7 µM -1.5232033129696 0.0616432343725088 no 3125 0.063853923753908 4469 1005053 YMR079W SEC14 SGTC_1093 fluphenazine 7.97 µM -1.52614230066631 0.0612882106484821 no 3126 0.0634872146725717 4544 6602611 An atypical antipsychotic. SGTC_1289 0976-0073 69.1 µM -1.52768479814526 0.0611025204273495 no 3127 0.0632954081389755 4570 3391136 SGTC_1224 0823-0416 294 µM -1.5285903840665 0.0609937084559973 no 3128 0.0631830106693765 4533 3598164 SGTC_345 1362-0200 395 µM -1.52882746171659 0.060965247085522 no 3129 0.0631536112857385 4495 1419823 SGTC_1421 4029-0249 71.4 µM -1.53076131070721 0.0607334744935399 no 3130 0.0629141973900645 4579 2894095 SGTC_2686 alizarin 95.37 µM -1.53223652649158 0.0605571330803758 no 3131 0.0627320389838167 4481 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_906 1165-0455 526 µM -1.53582512615198 0.0601298385556123 no 3132 0.0622906377700986 4497 3252859 SGTC_2795 7780010 54.55 µM -1.53712053191067 0.059976175744647 no 3133 0.0621318979616443 4470 953673 SGTC_2786 7743617 45.45 µM -1.5383338780934 0.0598325260414055 no 3134 0.0619835001871332 4458 583674 SGTC_2764 methyldopa 94.69 µM -1.54112580973618 0.0595030090811084 no 3135 0.0616430846987441 4474 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2546 rhodinyl acetate 100 µM -1.5412619308054 0.0594869798679847 no 3136 0.06162652508375 4475 6708682 SGTC_2432 5630864 12.22 µM -1.5415216483789 0.0594564056870823 no 3137 0.0615949391486102 4525 5714970 SGTC_2018 5133068 143 µM -1.54266104383777 0.0593224205848262 no 3138 0.0614565192535946 4480 785362 SGTC_1516 st013856 110 µM -1.54268647639555 0.0593194325935218 no 3139 0.0614534323440062 4533 5281404 A mutagen and neurotoxin. SGTC_789 1309-1135 70.6 µM -1.54510397489235 0.0590359466170734 no 3140 0.0611605578481788 4502 3092424 SGTC_2867 9039098 71.43 µM -1.55437333464568 0.0579588218845083 no 3141 0.0600476949900393 4500 6463460 SGTC_346 4513-0042 7.16 µM -1.55446025911924 0.0579487946252411 no 3142 0.0600373345438992 4465 2827372 SGTC_1179 1021-1431 9.29 µM -1.55491058710496 0.0578968684200998 no 3143 0.0599836827840592 4539 2840958 SGTC_2436 5633522 8.09 µM -1.55720093058875 0.0576333404191236 no 3144 0.0597113937592502 4509 5724242 SGTC_2058 5236698 133 µM -1.5588336842993 0.0574460516294451 no 3145 0.0595178747161541 4491 766665 SGTC_3293 9120939 62.045 µM -1.55901681466959 0.0574250751342917 no 3146 0.0594962002301817 4507 934087 SGTC_1777 st045864 34.765 µM -1.55963030503854 0.0573548473649774 no 3147 0.0594236353491401 4538 4691462 SGTC_1510 1123-0200 71.5 µM -1.55971611724543 0.057345029617611 no 3148 0.059413490841171 4527 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1502 4534-4282 27.7 µM -1.56084203410328 0.0572163362884994 no 3149 0.0592805134512669 4522 3278949 SGTC_1716 st033144 30.6155 µM -1.56188038615324 0.0570978532723914 no 3150 0.0591580849391389 4489 674617 SGTC_386 1509-0011 3.07 µM -1.56314163605754 0.0569541959755722 no 3151 0.0590096421347802 4532 3107280 SGTC_2437 5741531 144.16 µM -1.56437945422906 0.0568134844345043 no 3152 0.0588642414016145 4540 2262990 SGTC_1612 st002233 45.4 µM -1.56620851120087 0.056606063975304 no 3153 0.0586499054096163 4553 1035021 SGTC_2021 4019055 173 µM -1.57203666597806 0.0559491116194865 no 3154 0.0579710240313619 4323 44827708 YER133W GLC7 SGTC_778 3456-2434 196 µM -1.57530196091301 0.0555836833638823 no 3155 0.0575933807920525 4459 5539063 SGTC_1635 st007035 42.4 µM -1.57643403017565 0.0554574310573948 no 3156 0.0574629054812921 4487 3716403 SGTC_1900 st060200 72.8 µM -1.5818133076675 0.0548606065212001 no 3157 0.0568460980713388 4518 688945 SGTC_2752 diclazuril 33.15 µM -1.58233302340001 0.0548032146276381 no 3158 0.0567867828636237 4452 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1860 st056228 74.6 µM -1.5832087898383 0.0547066116482841 no 3159 0.0566869418481183 4524 688679 SGTC_2541 muurolladie-3-one 83.07 µM -1.59317725281531 0.0536164855474595 no 3160 0.0555602163454629 4469 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2823 7987624 58.44 µM -1.59338571719206 0.0535938734545718 no 3161 0.0555368439254322 4488 2239440 SGTC_326 k292-0812 17.5 µM -1.59685024684024 0.0532191815475479 no 3162 0.0551495462015371 4544 3579357 SGTC_1926 methyl fluorone black 53.6 µM -1.60438062034243 0.0524119281151386 no 3163 0.0543150900512093 4178 72721 Reacts with homocysteine. SGTC_186 3455-3465 67.277 µM -1.6056971731277 0.0522717976812383 no 3164 0.0541702313599939 4558 755278 SGTC_2153 5569715 200 µM -1.61156751635491 0.051650591043688 no 3165 0.0535280420608071 4570 2054701 SGTC_2128 5255449 168.493 µM -1.61474782771575 0.0513165061121853 no 3166 0.0531826577685147 4476 736008 SGTC_1370 2001-0092 44.6 µM -1.61734103057895 0.0510453698985388 no 3167 0.0529023435627983 4530 790957 SGTC_1572 epiandrosterone 68.9 µM -1.61809886011929 0.0509663495488408 no 3168 0.0528206470699108 4507 441302 A steroid. SGTC_2811 7967822 32.47 µM -1.61964532333995 0.0508053989508238 no 3169 0.0526542438276154 4572 2232244 SGTC_985 1493-0307 8.71 µM -1.62917613478923 0.0498223792199544 no 3170 0.0516378687808664 4592 3278274 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.63249098266136 0.0494840594596566 no 3171 0.0512880482726358 4578 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1655 st012546 55.1 µM -1.63332190840101 0.0493995416571321 no 3172 0.0512006557074054 4553 720985 YLR208W SEC13 SGTC_3276 9139060 49.47 µM -1.63811532568756 0.0489142257011327 no 3173 0.0506988192769267 4633 4870619 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.64214177155443 0.0485095134899225 no 3174 0.0502803133185226 4488 5355888 SGTC_1633 st005664 67.9 µM -1.65065164580006 0.0476629666401218 no 3175 0.0494048633433946 4551 2063822 SGTC_419 nsc-638432 893 µM -1.65181517294557 0.0475481461240846 no 3176 0.0492861173156894 4549 368090 SGTC_1212 0520-0165 585 µM -1.65380111441588 0.0473526791204005 no 3177 0.0490839647385809 4600 5403258 SGTC_965 1291-5240 308 µM -1.65857083968566 0.0468858471981581 no 3178 0.0486011509200379 4563 2834598 SGTC_895 0964-0006 13.7 µM -1.66305967363213 0.0464498857546176 no 3179 0.0481502455335093 4582 6738897 SGTC_924 2046-0044 21.3 µM -1.6638371785597 0.046374705120886 no 3180 0.0480724860000872 4541 3623589 SGTC_674 0498-0004 451 µM -1.66428468421214 0.0463314779931816 no 3181 0.0480277758181876 4566 4231473 SGTC_2759 disulfiram 3.38 µM -1.66564347626379 0.0462004227190757 no 3182 0.0478922231451602 4478 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_73 0327-0325 16.231 µM -1.66989434058166 0.0457923491025838 no 3183 0.0474701351328491 4390 53298 SGTC_2332 7982454 138.89 µM -1.67007607973896 0.0457749673230832 no 3184 0.0474521560570594 4474 2981748 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.67037962994649 0.0457459471949142 no 3185 0.047422138634791 4601 804 An inhibitor of viral and cellular DNA polymerases. SGTC_573 3702-0553 84.7 µM -1.67093078704193 0.0456932930560528 no 3186 0.0473676747969912 4514 1222756 SGTC_36 0335-0881 14.2 µM -1.67915553428119 0.0449133245710844 no 3187 0.0465608676973071 4486 23828853 SGTC_2253 7938677 135.83 µM -1.68387451057185 0.0444706763096413 no 3188 0.0461029616873506 4613 2301972 SGTC_139 0099-0334 718.624 µM -1.6890015228337 0.0439937445318522 no 3189 0.0456095690617745 4579 97690 SGTC_1979 st071809 45.3 µM -1.69327768217257 0.0435991242968757 no 3190 0.0452013120767851 4621 4976333 SGTC_2596 sinensetin 100 µM -1.69430220141657 0.0435050032191619 no 3191 0.0451039362381707 4578 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2973 9094665 17.96 µM -1.69936105788509 0.0430426551842415 no 3192 0.0446255873186431 4563 25237061 YIL048W NEO1 SGTC_2675 theaflavin digallate 100 µM -1.71603306865259 0.0415469697617694 no 3193 0.0430779950616778 4541 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1753 st043925 64 µM -1.71674895833535 0.041483700590014 no 3194 0.0430125252901011 4613 670181 SGTC_1316 1272-0050 65.9 µM -1.71891259870228 0.0412929559721903 no 3195 0.0428151438713471 4604 7340392 SGTC_781 4335-2806 94.4 µM -1.71969477889516 0.0412241748679642 no 3196 0.0427439686979642 4624 845254 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.72121456506763 0.0410907978670472 no 3197 0.042605947891649 4630 5106787 A p450 inhibitor. SGTC_4 0960-0234 25.671 µM -1.72355004553118 0.040886517491617 no 3198 0.0423945516223161 4569 6821112 SGTC_2998 9066762 71.4286 µM -1.72709366545065 0.0405781373927074 no 3199 0.0420754215377354 4600 4945196 SGTC_984 1492-0255 2.91 µM -1.74298317133774 0.0392185029022512 no 3200 0.040668277222111 4567 1585198 SGTC_3280 9140961 49.47 µM -1.74432526506456 0.0391053811424691 no 3201 0.040551194260182 4630 4901226 SGTC_1404 3909-7820 48.3 µM -1.75612725966626 0.0381220167830309 no 3202 0.0395333407504213 4590 23741373 SGTC_421 streptovitacin 30 mM -1.75990037134819 0.0378119223827221 no 3203 0.0392123501825958 4578 91467 include heat shock SGTC_488 nitrendipine 139 µM -1.76361434960561 0.0375087013787928 no 3204 0.0388984650607449 4625 4507 Dihydropyridine L-type calcium channel blocker. SGTC_719 2810-4230 27.3 µM -1.77115940302984 0.0368988132218552 no 3205 0.0382670990325733 4640 721079 SGTC_121 0557-0495 61.343 µM -1.77142563757512 0.0368774417025266 no 3206 0.0382449742017084 4634 3104427 SGTC_3264 9137442 49.47 µM -1.7721713234064 0.0368176369243559 no 3207 0.0381830611528818 4572 17015726 SGTC_1077 5-fluorocytosine 377 nM -1.77837042744714 0.0363235266298971 no 3208 0.0376715181661578 4641 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2267 7931562 200 µM -1.78028852474076 0.0361717455597914 no 3209 0.0375143770725233 4579 934880 SGTC_3023 9089636 49.47 µM -1.78208757110989 0.0360298574488258 no 3210 0.0373674761537873 4679 17249241 SGTC_2789 5281112 71.43 µM -1.78957328982946 0.0354443564255926 no 3211 0.0367612678100481 4632 765948 SGTC_689 0833-0039 98 µM -1.79952986614491 0.0346777081882514 no 3212 0.035967451963293 4588 5374726 SGTC_2029 5175081 200 µM -1.80253297059598 0.0344491630604532 no 3213 0.035730796089989 4578 1380876 SGTC_189 3970-0742 2.116 µM -1.81084170452311 0.0338232856704049 no 3214 0.0350826792864631 4613 2891807 SGTC_2534 helenine 20.12 µM -1.81513757234623 0.0335033748899183 no 3215 0.0347513852267049 4635 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2111 5486399 200 µM -1.81537165800076 0.0334860144752951 no 3216 0.0347334067751222 4593 689674 SGTC_1000 4048-0884 8.67 µM -1.82685551517636 0.0326433916279111 no 3217 0.0338607481418411 4629 13040088 SGTC_1985 st071382 65.5 µM -1.83059994068436 0.0323724557779242 no 3218 0.0335801387138156 4634 6123237 SGTC_1702 st027038 51 µM -1.83082868292618 0.0323559649647294 no 3219 0.0335630588568452 4665 5521182 SGTC_174 3553-0389 74.3 µM -1.83531333689951 0.0320340486133748 no 3220 0.0332296380419902 4650 738071 SGTC_2433 5607874 27.82 µM -1.84960289520312 0.0310259126167772 no 3221 0.0321854026164857 4604 2252428 SGTC_1522 st012842 45.6 µM -1.85524411990191 0.0306352162125492 no 3222 0.0317806869626271 4488 3491067 YOR116C RPO31 SGTC_1427 4048-4900 550 nM -1.85578957973956 0.0305976560786004 no 3223 0.0317417782078118 4630 24132586 SGTC_3253 9135987 49.47 µM -1.85894756758603 0.0303809472611712 no 3224 0.031517285365946 4655 4182430 SGTC_429 1112-0049 25.5 µM -1.86644935655085 0.0298712513031654 no 3225 0.0309892616088524 4606 2836170 SGTC_1905 st060207 84.5 µM -1.8670717021434 0.0298292876401816 no 3226 0.0309457877581788 4640 1948547 SGTC_1815 st051655 58.2 µM -1.87126454245406 0.0295478446682369 no 3227 0.0306542113125759 4630 5984156 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.87176965250487 0.0295140885764398 no 3228 0.030619239244138 4665 7104 SGTC_2385 9074692 200 µM -1.87274269178698 0.0294491513869839 no 3229 0.0305519625127613 4650 17046906 SGTC_1540 guanosine 70.6 µM -1.87365919780498 0.0293880955515143 no 3230 0.0304887065561816 4613 6802 Guanosine is a purine nucleoside SGTC_3143 9086658 49.47 µM -1.87516264790852 0.0292881663004874 no 3231 0.030385175527204 4603 25236626 SGTC_3018 9082602 49.47 µM -1.87567518383221 0.0292541643350045 no 3232 0.0303499477730251 4538 17332089 SGTC_2877 9040724 71.43 µM -1.87597548884473 0.02923425714309 no 3233 0.0303293228583224 4608 6463895 SGTC_2485 5633444 17.78 µM -1.88424899160276 0.0286902171822006 no 3234 0.0297656517575504 4627 5724239 SGTC_1405 3909-7894 12 µM -1.88830790982983 0.0284264092697994 no 3235 0.0294923130272199 4651 7104060 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.89889042504427 0.0277480799267757 no 3236 0.0287894422639466 4616 364106 SGTC_3191 9110352 49.47 µM -1.89926346362568 0.0277244167623415 no 3237 0.0287649220775868 4620 17122424 SGTC_193 1273-0060 1.558 µM -1.90178826638608 0.0275647012313935 no 3238 0.0285994204378149 4548 2847393 YHR072W ERG7 SGTC_2163 5671233 125 µM -1.90949205121026 0.0270821041968917 no 3239 0.0280993230829281 4610 701023 SGTC_510 ag-490 170 µM -1.91314230214121 0.0268559110867219 no 3240 0.027864918770034 4745 5328779 SGTC_1494 4358-1428 177 µM -1.92229036616352 0.0262959595496444 no 3241 0.0272846157659103 4700 1564571 SGTC_1420 4'-methoxyflavone 42 µM -1.9240357412487 0.0261902417907217 no 3242 0.0271750518042118 4677 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1706 st031321 9.9705 µM -1.93030410270665 0.0258134914103608 no 3243 0.0267845845049909 4690 6103185 SGTC_1288 0973-0013 65.5 µM -1.93301237435277 0.0256521235976413 no 3244 0.0266173367179072 4686 4315430 SGTC_2822 7994718 71.43 µM -1.94324896491654 0.0250498022886685 no 3245 0.0259930422595496 4674 1018011 SGTC_2085 5307070 144.047 µM -1.94363124750056 0.0250275403777361 no 3246 0.0259699674426725 4625 2840351 SGTC_2031 5180455 200 µM -1.94384155410042 0.0250153004199624 no 3247 0.0259572805125502 4668 29949 SGTC_2081 5214970 32.255 µM -1.95021392731131 0.024646797768929 no 3248 0.0255753132452904 4639 2063512 SGTC_44 0929-0055 61.211 µM -1.95300030608612 0.02448710371457 no 3249 0.025409779461103 4524 1379590 SGTC_2225 6654152 15.4 µM -1.95656583442868 0.0242840222931157 no 3250 0.0251992675871501 4645 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2251 lansoprazole 556 µM -1.95733724422409 0.0242402717858096 no 3251 0.0251539157077767 4659 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1921 5740136 50 µM -1.96322239890154 0.0239086693847116 no 3252 0.0248101688931384 4605 1774243 SGTC_2279 7948423 32.93 µM -1.96990142504155 0.0235369628883044 no 3253 0.0244248345473306 4616 1247112 SGTC_3057 9095946 49.47 µM -1.9729298534183 0.0233700310197233 no 3254 0.0242517774063008 4702 24540043 SGTC_2074 5212007 75.395 µM -1.97813667423428 0.0230853517983388 no 3255 0.0239566451306221 4642 758611 SGTC_3268 9137683 49.47 µM -1.9789847656497 0.0230392606890189 no 3256 0.0239088607546254 4719 1953228 SGTC_2355 9061122 103.12 µM -1.99845256503305 0.0220023651651184 no 3257 0.0228338088420539 4688 5302957 SGTC_1774 st048371 48.465 µM -2.00187680294852 0.0218241193663245 no 3258 0.0226489915418304 4677 4242727 SGTC_2934 9036370 36.88 µM -2.03155654097071 0.0203296529013821 no 3259 0.0210992850422499 4644 6462800 SGTC_1520 flindersine 88 µM -2.03277248022613 0.0202703234729593 no 3260 0.0210377573430211 4677 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2287 7945887 168.79 µM -2.03620042311842 0.0201038532338912 no 3261 0.0208651169007814 4712 1245853 SGTC_1747 st037496 66.6 µM -2.04380993487392 0.0197384546191661 no 3262 0.0204861636607911 4639 723305 SGTC_3266 9136860 49.47 µM -2.05124384855401 0.019386947609536 no 3263 0.0201216028500893 4458 4871271 YPR165W RHO1 SGTC_2584 androsterone 48.74 µM -2.06866212966355 0.0185841143615482 no 3264 0.0192889016446978 4593 2754130 A steroid. SGTC_1603 st002045 67.8 µM -2.06868642258926 0.0185830147384894 no 3265 0.0192877610611429 4705 5887985 SGTC_701 4424-0219 185 µM -2.06923858849018 0.0185580357976453 no 3266 0.0192618516276462 4705 2911779 SGTC_1513 0337-0559 19 µM -2.07289478940088 0.0183933564921311 no 3267 0.0190910360350656 4675 775073 SGTC_2858 9025781 8.96 µM -2.0758070545939 0.0182630769828662 no 3268 0.0189558998248394 4521 4894980 YPL153C RAD53 SGTC_1209 2323-2347 50.3 µM -2.07780111558479 0.0181743273117882 no 3269 0.0188638405235117 4699 5412760 SGTC_3256 9138902 49.47 µM -2.08394412835485 0.0179032270940726 no 3270 0.0185826248635052 4772 17228773 SGTC_2821 7996764 71.43 µM -2.09030737354768 0.0176260518140954 no 3271 0.018295098672449 4660 2987135 SGTC_2755 lomerizine 42.69 µM -2.09331510278319 0.0174963186571559 no 3272 0.0181605176685306 4651 3949 A calcium channel blocker. SGTC_1750 st081859 2.357 µM -2.10092411271181 0.0171717520600149 no 3273 0.0178238141823021 4627 5291695 SGTC_2291 7917025 104.35 µM -2.10691308416167 0.0169199204375361 no 3274 0.0175625571245209 4637 2964612 SGTC_252 miconazole 1.30953 nM -2.11091288530646 0.0167534963583576 no 3275 0.0173899001704626 4643 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3145 9085516 49.47 µM -2.11206778208963 0.0167057046214049 no 3276 0.0173403179556012 4672 25236195 SGTC_2006 4011487 200 µM -2.11250026128248 0.0166878378845437 no 3277 0.0173217817882444 4650 45595294 SGTC_1650 st011916 45.8 µM -2.11554962880193 0.0165623247464827 no 3278 0.0171915648840108 4701 242528 SGTC_299 1273-0059 1.44 µM -2.13519838445054 0.0157727947802732 no 3279 0.0163724044131888 4485 2848077 SGTC_117 lucigenin 22.078 µM -2.14576349190658 0.0153617707441293 no 3280 0.0159459263623552 4668 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1608 st001473 40.5 µM -2.14992967464294 0.0152022369015817 no 3281 0.0157803889721664 4713 7292267 SGTC_1423 4048-0112 5.59 µM -2.15159786361632 0.0151387578518818 no 3282 0.0157145202724829 4745 X1423 SGTC_2709 st078560 56 µM -2.16008594323639 0.0148192798027662 no 3283 0.0153830085001927 4692 17250903 SGTC_95 0471-0001 561.058 µM -2.16364669759563 0.0146869948626588 no 3284 0.0152457373574592 4695 4015405 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.16947439732076 0.0144726828623584 no 3285 0.0150233430348139 4744 279621 SGTC_2611 pyromycin 23.93 µM -2.1758228885338 0.014242287845842 no 3286 0.0147842532593233 4673 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2810 7959871 45.46 µM -2.18418539145326 0.013943628589965 no 3287 0.0144743139726308 4667 2974535 SGTC_2566 crystal violet carbinol 226 nM -2.19279059410429 0.0136419538932593 no 3288 0.0141612349678132 4644 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2154 5570129 200 µM -2.19429857031872 0.0135896724828316 no 3289 0.0141069760866887 4741 673366 SGTC_1455 4262-0120 131 µM -2.20031699340645 0.0133827328817047 no 3290 0.0138922062218705 4735 1529587 SGTC_392 N-ethylmaleimide 8.33 µM -2.2092409246945 0.0130809001586191 no 3291 0.0135789438760277 4714 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1121 fusaric acid 630.51 nM -2.22184194046554 0.0126647272626537 no 3292 0.013146994622419 4712 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1834 st055981 52.8 µM -2.22303946654482 0.0126257794997939 no 3293 0.0131065694177237 4699 471719 YDL150W RPC53 SGTC_3239 9133757 49.47 µM -2.23725207162045 0.0121713942202414 no 3294 0.0126349348968472 4778 17036923 SGTC_83 0170-0301 39.027 µM -2.29122491768355 0.0105725408122781 no 3295 0.0109752042586077 4751 3089716 SGTC_2929 9013348 24.6 µM -2.29301442028257 0.0105228214818969 no 3296 0.010923587379758 4714 2995952 SGTC_1672 st016598 6.51 µM -2.29720134891183 0.0104072876050204 no 3297 0.0108036431115818 4715 4665860 YNL267W PIK1 SGTC_2971 9092186 9.93 µM -2.304731095173 0.0102022925850526 no 3298 0.0105908191276576 4690 25236400 SGTC_2777 climbazole 1.536 µM -2.31035381006397 0.0100515214269983 no 3299 0.0104342870463529 4544 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.32032333759719 0.0097889683919143 no 3300 0.0101616962807875 4732 688761 SGTC_1565 sinapyl alcohol 95.1 µM -2.33531245668767 0.00940549736083558 no 3301 0.00976355195256564 4731 5280507 A phenol propionate derived from cinnamic acid. SGTC_1707 st032323 6.317 µM -2.33727571806818 0.00935625679013377 no 3302 0.00971242614089467 4591 3132057 YMR211W DML1 SGTC_1047 2043-3044 82 µM -2.34678190862048 0.0091210083601846 no 3303 0.00946816757129621 4713 669592 SGTC_398 bronopol 33.3 µM -2.35480926573908 0.00892640593920659 no 3304 0.00926610764871577 4706 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_138 0850-0259 40.9225 µM -2.37214662204507 0.00851847821406924 no 3305 0.00884253557604401 4694 6813004 SGTC_1682 st012968 530 nM -2.37517178056866 0.00844900108547156 no 3306 0.00877039237800352 4721 24207270 SGTC_2227 7312221 64.1025 µM -2.38134613193003 0.00830874002506306 no 3307 0.00862474767066389 4782 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_94 0334-0113 514.748 µM -2.38787906288299 0.00816256352406216 no 3308 0.00847295855713449 4747 6795178 SGTC_1903 st060211 78.3 µM -2.38905444280867 0.00813650520917665 no 3309 0.00844589950109349 4748 688960 SGTC_2537 larixol 68.93 µM -2.40700285131255 0.00774757154124378 no 3310 0.00804202214363016 4738 6708759 SGTC_1621 st003705 32.4 µM -2.41670699049267 0.00754417871878483 no 3311 0.00783080935950441 4756 24207032 SGTC_2969 9091408 28.7 µM -2.41759335137735 0.00752583765282356 no 3312 0.00781176295511856 4701 4286311 SGTC_420 mitomycin C 81.9 mM -2.42053792220855 0.00746518863499137 no 3313 0.00774878137531288 4747 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2957 9076800 11.52 µM -2.42877004768922 0.00729791122118722 no 3314 0.00757506893499012 4713 16459615 SGTC_536 3852-0578 10.6 µM -2.44674201582954 0.00694415709822073 no 3315 0.00720769903396651 4753 2869208 SGTC_1129 3453-1384 223 µM -2.45213746771319 0.00684095200438796 no 3316 0.00710051989388986 4716 1084452 SGTC_3227 9130768 49.47 µM -2.46195847547185 0.00665656714138604 no 3317 0.00690903319252081 4781 17720899 SGTC_2904 7225135 42.03 µM -2.47995530964784 0.00633005793220329 no 3318 0.0065699425254154 4766 4446116 SGTC_3141 9094609 49.47 µM -2.51444493672259 0.00574372017867424 no 3319 0.00596099590096871 4746 25236309 YDL196W YDL196W SGTC_2875 9039966 71.43 µM -2.51995321788074 0.0056546806763059 no 3320 0.00586852162394884 4764 6463691 SGTC_2280 7785178 200 µM -2.53881847931776 0.0053589452876753 no 3321 0.00556137580553668 4758 2954328 SGTC_2319 6033012 152.6 µM -2.56016993023772 0.00504089349744815 no 3322 0.00523104963593312 4741 847246 SGTC_2281 7943571 200 µM -2.60235418657114 0.00446151556538794 no 3323 0.00462930887328249 4771 1244024 SGTC_2719 novobiocin 32.65 µM -2.61408284618512 0.00431136872169777 no 3324 0.00447336697717236 4774 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_389 tpck 16.7 µM -2.61485857998433 0.00430159913298313 no 3325 0.00446322033858069 4767 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2132 5317594 122.667 µM -2.61989182025692 0.00423868988300387 no 3326 0.00439788321267327 4739 794577 SGTC_1787 fluconazole 80 µM -2.64232827324845 0.00396815630828024 no 3327 0.00411691039506472 4494 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_310 1273-0058 1.06 µM -2.673952310553 0.0036130964642005 no 3328 0.00374815553872847 4453 2734232 SGTC_570 0987-0065 62.6 µM -2.70276369150675 0.00331472219886601 no 3329 0.00343828077694167 4750 3104428 SGTC_82 0054-0107 293.755 µM -2.72649817520282 0.0030857741640622 no 3330 0.00320051532748152 4778 3104697 SGTC_2865 9030313 51.95 µM -2.73319696426825 0.00302378543934262 no 3331 0.0031361405626435 4775 42562754 SGTC_2529 gangaleoidin 93.61 µM -2.78058130713006 0.00261639178198596 no 3332 0.00271308349216926 4772 4565183 SGTC_172 1112-0046 2.638 µM -2.81134624237209 0.00237914509315343 no 3333 0.00246673320997561 4768 2802135 YIL048W NEO1 SGTC_2294 7971431 200 µM -2.8490810408616 0.00211481911941054 no 3334 0.00219228552363931 4774 5741572 SGTC_3015 9080845 49.47 µM -2.95466023625552 0.00151061637980456 no 3335 0.00156506779732268 4795 5296973 SGTC_304 1310-0298 97 µM -2.99349217448658 0.00133135292769465 no 3336 0.00137902290752449 4650 1550234 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -3.05194527291273 0.00109793069504645 no 3337 0.00113681775036383 4783 6857784 SGTC_2869 9037858 32.47 µM -3.12813049113187 0.000849973872150835 yes 3338 0.000879610290136503 4787 27187042 SGTC_1909 st060837 51.5 µM -3.16729761809451 0.000743611885184845 yes 3339 0.000769313817380009 4777 678937 SGTC_1901 st060216 58.6 µM -3.20208556886919 0.000659570847152056 yes 3340 0.000682182316237972 4797 688792 SGTC_2952 9073731 13.78 µM -3.24584658789167 0.000566304945302448 yes 3341 0.000585509626977721 4779 16457353 SGTC_2832 7992762 51.95 µM -3.29269932941111 0.000480071725639285 yes 3342 0.000496152651698397 4760 2985177 SGTC_1892 st058411 7.36 µM -3.400012734748 0.000326318048598504 yes 3343 0.000336913574016001 4793 3934738 SGTC_431 k089-0097 107 µM -3.46864864553856 0.000253491227816315 yes 3344 0.000261541532333303 4663 5499420 SGTC_1745 st081495 74 µM -3.5203568201263 0.000208965137293995 yes 3345 0.000215483300773456 4759 13842402 YBL026W LSM2 SGTC_137 0438-0332 85.389 µM -3.63702777149264 0.000133907043564257 yes 3346 0.000137901102306349 4784 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1688 st021091 57.6 µM -3.79936795470869 7.05765128390509e-05 yes 3347 7.25327893619951e-05 4808 3656366 SGTC_1785 bathophenanthroline 24 µM -3.80199014116096 6.98359876190001e-05 yes 3348 7.17692201606634e-05 4789 72812 An iron chelator. SGTC_1930 st074634 34.3 µM -3.83761850732119 6.04726131810867e-05 yes 3349 6.21166423064059e-05 4788 684253 YOR116C RPO31 SGTC_351 caspofungin 25 nM -3.86902031443131 5.32138640511349e-05 yes 3350 5.46367692504798e-05 4807 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1786 berberine 21.6 µM -3.90235021297509 4.64130204985768e-05 yes 3351 4.76315949393647e-05 4778 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_374 0880-0231 82.3 µM -3.94728275756736 3.85356259980843e-05 yes 3352 3.9521592471048e-05 4787 6833587 SGTC_1928 4'-methoxychalcone 40.3 µM -3.97396290771155 3.44752124682392e-05 yes 3353 3.53432880392036e-05 4806 641818 SGTC_2582 agaric acid 100 µM -4.12711269045235 1.79592568250496e-05 yes 3354 1.83673202324532e-05 4716 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2942 9052777 62.25 µM -4.14665974926692 1.64985986304037e-05 yes 3355 1.68680412749273e-05 4801 6469503 SGTC_2911 7942208 15.64 µM -4.41371448592404 4.99300441454257e-06 yes 3356 5.08059746453799e-06 4808 1243384