SGTCid condition conc unit YJL144W|YJL144W.score YJL144W|YJL144W.strain.pval YJL144W|YJL144W.strain.significant YJL144W|YJL144W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2805 7950783 58.44 µM 5.72721071788525 8.88709910011199e-10 yes 1 5.10476624734922e-09 4 1178958 YDL195W SEC31 SGTC_2669 eugenol 100 µM 4.37451692639679 2.16013871662736e-06 yes 2 6.08508401661373e-06 7 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2288 7946289 167.31 µM 4.25965196292333 3.82714766362407e-06 yes 3 1.02372730021773e-05 20 1246052 SGTC_658 3253-0951 102 µM 4.22578461770147 4.51805551002367e-06 yes 4 1.19054828272898e-05 52 1184878 SGTC_1096 rimcazole 32.2 µM 4.207738414364 4.93334659339495e-06 yes 5 1.28969602722687e-05 4 18528119 A dopamine reuptake inhibitor. SGTC_936 3005-4620 401 µM 4.15453030495475 6.38072261265348e-06 yes 6 1.62978208267936e-05 16 777207 SGTC_1942 st076330 65.2 µM 4.04280486923912 1.0845182028186e-05 yes 7 2.64077864504636e-05 26 24208414 SGTC_580 1123-0028 41 µM 3.99223350648691 1.37285519490864e-05 yes 8 3.27269360655975e-05 35 1677248 YPR107C YTH1 SGTC_1395 3486-0190 4.35 µM 3.88967215759258 2.19619325526795e-05 yes 9 5.01898686535279e-05 11 6748079 SGTC_1825 st052143 62.6 µM 3.72784246319241 4.50647128239256e-05 yes 10 9.65630159350374e-05 19 674173 SGTC_1106 tegaserod maleate 11.7 µM 3.69588984481005 5.17675832942105e-05 yes 11 0.000109558984441277 30 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_256 clotrimazole 625 nM 3.54846526371166 9.68015611377304e-05 yes 12 0.000193741551746513 38 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_628 1636-0253 16 µM 3.37591383264646 0.000195652246867923 yes 13 0.000367854784218649 52 4456143 SGTC_3194 9111903 49.47 µM 3.15167344460429 0.000466117361895133 yes 14 0.000811688581222067 53 17087251 SGTC_2380 9035439 200 µM 3.14612649322825 0.000475919833300103 yes 15 0.000827242165991377 69 6462575 SGTC_1846 st056244 14.8 µM 3.10863848607252 0.000547338553707361 yes 16 0.000939757696800192 70 5393182 SGTC_3188 9110789 49.47 µM 3.0932031239738 0.000579527768321911 yes 17 0.000990042779675333 62 849217 SGTC_2678 equilin 100 µM 3.08686030461831 0.000593255409589514 yes 18 0.00101141317227061 53 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_420 mitomycin C 81.9 mM 3.07280846817685 0.000624744229294827 yes 19 0.00106027271595061 51 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_65 0798-0905 34.986 µM 3.07248974286338 0.000625476039274884 yes 20 0.00106140564333124 154 3602145 SGTC_383 2324-0395 7.37 µM 3.03700995307669 0.000712069297721905 yes 21 0.00119468783022705 90 3146421 SGTC_1340 1486-1359 257 µM 3.03177156664979 0.000725752417899508 yes 22 0.00121561557972021 55 4309068 SGTC_3213 9129884 49.47 µM 3.02890688132936 0.000733337326467949 yes 23 0.00122720161069242 52 17190742 SGTC_2406 ethylparaben 405.7 µM 3.01180983454578 0.000780145386950773 yes 24 0.00129847614578854 82 8434 A possible steroid mimic. SGTC_1921 5740136 50 µM 3.00094065514624 0.00081131727236397 yes 25 0.00134573506786099 117 1774243 SGTC_2290 7904846 200 µM 2.91674993600057 0.00109445000803255 no 26 0.00176849608594778 88 2962154 SGTC_529 4076-0302 30.3 µM 2.87501390233201 0.00126610319940224 no 27 0.00202004854293077 59 5816522 SGTC_154 3389-1638 511.116 µM 2.84977269551967 0.00138152397390268 no 28 0.00218752417168402 80 5238686 SGTC_2442 5158906 48.48 µM 2.83321656446374 0.00146236718589094 no 29 0.00230410771902751 77 1893835 SGTC_351 caspofungin 25 nM 2.83215245780759 0.00146770800631139 no 30 0.00231178988806467 191 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1317 1273-0028 910 nM 2.80972988554536 0.0015844692130362 no 31 0.00247915472605541 112 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1306 1185-0270 9.02 µM 2.7517633217801 0.00192659149340213 no 32 0.00296376718139172 112 1548076 SGTC_2702 st077768 96.8 µM 2.74739279959355 0.00195492801848028 no 33 0.00300355714486807 83 6484119 SGTC_2787 5284540 71.43 µM 2.73902490075709 0.0020102403243575 no 34 0.00308108530318066 94 736958 SGTC_3095 9117207 49.47 µM 2.70532674856428 0.00224765874781693 no 35 0.00341186163273751 47 17015229 SGTC_1368 1852-0141 284 µM 2.69941788957966 0.00229181580064911 no 36 0.00347304470700766 110 2838987 SGTC_2167 5876490 200 µM 2.6752574727867 0.00248065740803368 no 37 0.00373359392500439 105 686534 SGTC_10 0279-0212 42.575 µM 2.65430478566004 0.00265570050428437 no 38 0.003973600426278 241 39851 YBR002C RER2 SGTC_845 0330-0138 4.51 µM 2.6160270188006 0.00300452242627054 no 39 0.00444797589513745 89 9039800 SGTC_2441 5730946 39.09 µM 2.60536148405189 0.00310880838565377 no 40 0.00458886872992323 101 1774275 SGTC_2715 st079500 56.4 µM 2.59860122380878 0.00317658538937139 no 41 0.00468022214232159 77 28246688 SGTC_1126 isoteolin 1.0172 µM 2.59458482923836 0.00321747986812048 no 42 0.00473526199736094 119 133323 SGTC_1151 3909-8316 15.3 µM 2.57805022013407 0.00339086761486198 no 43 0.00496797782524739 101 800431 SGTC_2938 9059746 27.26 µM 2.57586845637799 0.00341436274571636 no 44 0.00499943388869964 129 6471769 SGTC_389 tpck 16.7 µM 2.55707245056557 0.00362291191767461 no 45 0.00527786149346716 107 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2638 epoxomicin 18 µM 2.55076651428183 0.00369539802484663 no 46 0.00537431537586053 104 9915668 A protesome inhibitor. SGTC_442 cape 100 µM 2.55032367934485 0.00370053692383432 no 47 0.00538114738274521 79 5281787 SGTC_1098 clofazimine 15.1 µM 2.54230521375776 0.00379470311692035 no 48 0.00550619816169662 135 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1324 1418-0026 34.4 µM 2.53120729815165 0.00392857698368392 no 49 0.00568353230957369 99 1372513 SGTC_456 gingerol 170 µM 2.5239418498724 0.00401849605198478 no 50 0.00580235614042594 112 442793 A herb. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.49952120031953 0.00433439233877487 no 51 0.00621806289507004 125 6708760 SGTC_2327 6189656 200 µM 2.47611145748117 0.00465785977953815 no 52 0.00664110532596288 109 5349088 SGTC_2812 7970281 58.44 µM 2.47314046145533 0.00470041567958986 no 53 0.00669657459017722 141 2233435 SGTC_3242 9133940 49.47 µM 2.45752465368427 0.0049298460714745 no 54 0.00699491040536888 110 17248444 SGTC_1804 st050076 49.1 µM 2.44008571735153 0.00519781004712442 no 55 0.00734188864474442 127 3895976 SGTC_1134 3477-0009 42.5 µM 2.4223193027891 0.00548405824844495 no 56 0.00771089665787931 169 3973534 SGTC_1131 3454-3128 32.3 µM 2.42118857094302 0.00550274167301455 no 57 0.00773492504706607 176 710982 SGTC_1862 st057513 3.81 µM 2.4159165775151 0.00559060103257814 no 58 0.00784782845263726 94 5393163 SGTC_55 0767-0285 6.563 µM 2.40972311145089 0.00569540686915661 no 59 0.00798231571985162 152 3116166 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.40274902728563 0.00581550694361794 no 60 0.0081361754676444 146 521171 SGTC_19 0279-0214 38.434 µM 2.37883235196011 0.00624461617765867 no 61 0.00868378637051867 213 3566274 YBR002C RER2 SGTC_2753 fluvastatin 17.09 µM 2.36633042657348 0.00647989645486287 no 62 0.00898270109529472 151 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1732 st034308 51.822 µM 2.35688847255437 0.00666275324695038 no 63 0.00921439036153864 154 830119 SGTC_73 0327-0325 16.231 µM 2.3547330275398 0.00670513049739813 no 64 0.00926800878267981 211 53298 SGTC_535 2293-4129 48.2 µM 2.32461800248376 0.00732261424386139 no 65 0.0100461976535849 219 396118 YIL048W NEO1 SGTC_3000 9075062 71.4286 µM 2.32156263277657 0.00738797958781261 no 66 0.0101282489605612 132 17057871 SGTC_1002 4049-0206 172 µM 2.31107033013076 0.00761637923511989 no 67 0.0104144852496185 197 4662749 SGTC_3047 9092122 49.47 µM 2.29536429058573 0.00796989210047104 no 68 0.0108561280115696 147 17173831 SGTC_3187 9109394 49.47 µM 2.28418454007253 0.00823024021825972 no 69 0.0111803438811182 175 17098090 SGTC_793 0488-0545 106 µM 2.27849401484133 0.00836560496605886 no 70 0.0113485803463533 163 292548 SGTC_3068 9116768 49.47 µM 2.27352502695511 0.00848540060058417 no 71 0.0114972798553446 159 41904888 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.26662185780834 0.00865432422575032 no 72 0.0117066678318875 184 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3086 9117350 49.47 µM 2.26091228804159 0.00879626115218778 no 73 0.0118823445261845 72 2679265 SGTC_2089 5281248 129.67 µM 2.23602508908079 0.00943904255875628 no 74 0.0126750638807099 165 2737878 SGTC_2315 7733312 200 µM 2.22962502641608 0.00961084030783163 no 75 0.0128861734871161 158 726316 SGTC_299 1273-0059 1.44 µM 2.22791133122312 0.00965730260842699 no 76 0.0129432142074385 146 2848077 SGTC_1655 st012546 55.1 µM 2.22129459357374 0.00983854492475608 no 77 0.0131655074061571 150 720985 YLR208W SEC13 SGTC_2318 6029776 164 µM 2.20930488853717 0.0101745384152162 no 78 0.0135767207017155 191 818325 SGTC_1223 0764-0573 147 µM 2.20586269403594 0.0102728316909772 no 79 0.0136968074957177 201 1609797 SGTC_3144 9087057 49.47 µM 2.20334843711612 0.0103451496859312 no 80 0.013785099734987 158 17249618 SGTC_692 k241-0027 77.8 µM 2.19819309056216 0.0104948230493874 no 81 0.0139676744280642 150 3600480 SGTC_2105 5350118 200 µM 2.19529599610304 0.0105797587714573 no 82 0.0140711859690336 166 2133313 SGTC_130 0136-0219 337.655 µM 2.18763722087314 0.0108071853624441 no 83 0.0143480191722833 172 234244 SGTC_2375 9072683 200 µM 2.18340278485538 0.0109347443258666 no 84 0.0145030805266554 197 16798029 SGTC_497 capsazepine 133 µM 2.17863978248206 0.0110797896504869 no 85 0.0146792191992312 152 2733484 A calcium channel blocker. SGTC_1220 1838-0075 193 µM 2.16508908009576 0.011501631161136 no 86 0.0151904320352484 164 5529645 SGTC_2156 5649887 115 µM 2.15714971820664 0.0117552136519492 no 87 0.0154970003945436 196 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_756 0508-1999 28.3 µM 2.15562665565093 0.0118044109362661 no 88 0.0155564147124359 166 6753853 SGTC_42 0133-0086 60.653 µM 2.14398208199299 0.0121864884058744 no 89 0.0160171612520938 172 162923 Model of phenazepam hydroxylation. SGTC_471 1-acyl-paf 4 µM 2.14137308739505 0.0122735488417926 no 90 0.0161219817227917 178 16759367 SGTC_438 sphingosine 6.67 µM 2.1288186172846 0.012700059354354 no 91 0.0166346350046897 149 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1004 4084-0029 199 µM 2.12778754859788 0.012735650812812 no 92 0.0166773510970701 183 716894 YLR208W SEC13 SGTC_3081 9117243 49.47 µM 2.1258955665644 0.0128011846477789 no 93 0.0167559780647083 171 45595589 SGTC_531 3788-1495 174 µM 2.12501832709162 0.0128316690256195 no 94 0.0167925418390186 198 2896655 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.12409662150091 0.0128637662445344 no 95 0.0168310324837206 198 5282309 SGTC_2264 7948757 110.76 µM 2.12157776129496 0.0129518367534196 no 96 0.0169366057630003 183 2971411 SGTC_2584 androsterone 48.74 µM 2.10292894633859 0.0136202497878087 no 97 0.0177359905321218 359 2754130 A steroid. SGTC_3001 9076041 71.4286 µM 2.0858634629176 0.0142577891648137 no 98 0.0184954963770459 164 16004211 SGTC_1609 st001574 46.4 µM 2.08403826977727 0.0143274733203037 no 99 0.0185783431642434 198 3960012 SGTC_2309 7664088 163.95 µM 2.07825513739762 0.0145502081538654 no 100 0.0188429330581231 251 704922 SGTC_1285 0929-0069 65.5 µM 2.07377148691274 0.014724938835953 no 101 0.0190502692180497 195 1206237 SGTC_1149 3909-7961 23.3 µM 2.06733685052008 0.0149788530745885 no 102 0.0193512120948933 200 735261 SGTC_2412 st077135 33.4 µM 2.06633371266999 0.0150187746291926 no 103 0.0193984901283961 217 13258915 SGTC_1994 st072947 40.9 µM 2.06182180215153 0.0151994663184714 no 104 0.0196123522892016 204 5286565 YDL195W SEC31 SGTC_1939 st074455 53.6 µM 2.0489297806895 0.0157260880757074 no 105 0.0202344908801214 231 1644229 SGTC_1779 st039427 55 µM 2.03748995685411 0.0162064207113255 no 106 0.0208004836815769 257 1124498 SGTC_1674 st016616 23.6 µM 2.03744168705424 0.0162084737880533 no 107 0.020802899973454 229 625830 SGTC_1487 3970-0795 2.82 µM 2.03369490086381 0.0163685185476016 no 108 0.0209911833032088 204 3765103 SGTC_1295 1013-0063 9.78 µM 2.02547207180461 0.0167245079460997 no 109 0.0214094567037857 205 6826038 SGTC_1793 st048256 72.231 µM 2.0238403689719 0.0167959310558589 no 110 0.0214932895454803 141 672022 SGTC_2055 5235184 200 µM 2.01957533311054 0.016983854092431 no 111 0.0217137279601836 228 2836034 SGTC_975 1335-0046 28.5 µM 2.00015341553397 0.0178625020329923 no 112 0.0227418501658735 252 16486740 SGTC_1973 st070275 50.2 µM 1.99579712796298 0.0180648187120884 no 113 0.0229780047807699 195 17118334 SGTC_2310 7668677 200 µM 1.99014202419934 0.018330366861521 no 114 0.0232876463185584 252 2197143 SGTC_2791 5663188 71.43 µM 1.989006782259 0.0183840736076788 no 115 0.0233502271824763 220 54690634 SGTC_1263 0774-1208 64.8 µM 1.97348072981914 0.0191321455305037 no 116 0.024220408962658 303 906585 SGTC_2029 5175081 200 µM 1.9660960460546 0.0194969383369382 no 117 0.0246437585295529 255 1380876 SGTC_2205 7238770 200 µM 1.96586171061738 0.019508610226962 no 118 0.0246572935249039 160 279867 SGTC_1493 4348-0038 111 µM 1.96341371521619 0.0196308963799584 no 119 0.0247990607247288 260 800424 SGTC_2763 lisinopril 49.32 µM 1.95811610112643 0.0198977609465845 no 120 0.0251081954255932 169 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1590 st077108 57.8 µM 1.95681938959499 0.0199635490953966 no 121 0.0251843532958134 173 5489485 SGTC_3231 9132313 49.47 µM 1.95293781071156 0.0201615834905868 no 122 0.025413482337576 207 4905967 SGTC_2054 5233173 129 µM 1.95080392529461 0.0202711601437719 no 123 0.0255401873684619 298 6889 SGTC_2586 curcumin 80 µM 1.94768379491481 0.0204322898001847 no 124 0.0257264051500686 320 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2483 5729050 27.16 µM 1.9461495296194 0.0205119195231143 no 125 0.0258183902315524 297 2865180 SGTC_3012 9080433 71.4286 µM 1.93335907693434 0.0211860448932975 no 126 0.0265959894181979 231 17688859 SGTC_1801 st050089 28.441 µM 1.92821791637772 0.0214622437695801 no 127 0.0269140133012474 371 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_959 1222-0044 107 µM 1.92325645872301 0.0217316684426518 no 128 0.0272239249477464 247 6083612 SGTC_2172 5754775 163.918 µM 1.92086753904445 0.0218624109088459 no 129 0.0273742045342349 255 2263357 SGTC_682 0kpi-0099 17 µM 1.91480355043833 0.0221972713348077 no 130 0.0277587807655182 294 1714895 YML126C ERG13 SGTC_1983 st071813 46.9 µM 1.90689203982902 0.0226406517343727 no 131 0.0282672845970996 231 11838595 SGTC_1835 st008666 49.2 µM 1.90599332859336 0.0226914866872356 no 132 0.0283255356098209 197 690455 SGTC_2050 5263056 171 µM 1.89983838195747 0.0230422286194327 no 133 0.0287271661438802 303 763468 YGL055W OLE1 SGTC_2067 5224629 34.075 µM 1.89797397885681 0.0231493690850029 no 134 0.0288497549519062 268 2835000 SGTC_2377 9073351 62.6 µM 1.89098022226491 0.0235550198969442 no 135 0.0293134921997528 260 7337946 YHR072W ERG7 SGTC_381 3461-2219 42.7 µM 1.87538322155792 0.0244812471829575 no 136 0.0303700108503533 267 2883159 SGTC_104 0074-0074 590.992 µM 1.86877390418466 0.0248828633712825 no 137 0.0308271384706265 142 3943124 SGTC_2619 obliquin 87.91 µM 1.86455652193837 0.0251420097539409 no 138 0.0311217959788925 420 6708593 A bioactive alkalod. YER133W GLC7 SGTC_934 2950-0684 338 µM 1.85536533720695 0.0257146256202116 no 139 0.0317720368832738 273 1121253 SGTC_1460 k062-0059 9.15 µM 1.85530113752235 0.0257186633691506 no 140 0.0317766179370519 245 1373085 SGTC_3323 9138564 53.9225 µM 1.85467618919264 0.0257579963497532 no 141 0.0318212404724673 287 43912313 YNL103W MET4 SGTC_72 0744-0168 198.391 µM 1.85296096882024 0.025866207628884 no 142 0.0319439766252372 264 677577 SGTC_462 ag-879 158 µM 1.8479040544733 0.0261874586780874 no 143 0.0323081119511533 305 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1765 st044815 90.4 µM 1.84419345732511 0.026425298445709 no 144 0.0325774757674137 273 645695 SGTC_3131 9127911 49.47 µM 1.84410541636661 0.026430963497617 no 145 0.0325838893629421 270 45595681 SGTC_2852 9023854 51.95 µM 1.84114489716564 0.0266220517053419 no 146 0.0328001638869139 275 19798528 SGTC_3071 9117417 49.47 µM 1.83071588546322 0.0273044137426817 no 147 0.0335714803886563 195 45595590 YGL055W OLE1 SGTC_3217 9129673 49.47 µM 1.8302556648266 0.0273348586415111 no 148 0.0336058587872869 296 17248312 SGTC_1668 st014914 51.6 µM 1.82777446122328 0.0274994854753202 no 149 0.0337917038003696 237 2839556 SGTC_2754 granisetron 64.02 µM 1.82237315666191 0.0278607193933585 no 150 0.0341991923710859 302 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1663 st014140 55.4 µM 1.81075136342667 0.0286513882835277 no 151 0.0350896740506151 299 4207120 SGTC_994 3910-0338 138 µM 1.81058502478064 0.0286628389192168 no 152 0.0351025560064727 323 3479481 SGTC_673 1082-0474 110 µM 1.80575073347351 0.028997294348385 no 153 0.0354786420508908 372 3098046 SGTC_1117 retinoic acid 1.10837 µM 1.80527775502396 0.0290301903424448 no 154 0.0355156144058837 292 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3319 9138450 16.7555 µM 1.79328009709471 0.0298750616461646 no 155 0.0364640741018755 263 2029690 SGTC_466 geldanamycin 89.2 µM 1.78911261551077 0.0301732659525974 no 156 0.0367983404307761 180 5288382 HSP90 inhibitor. SGTC_1072 oxiconazole 14.9 nM 1.78658825859827 0.0303550933899233 no 157 0.0370020303998694 330 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1076 itraconazole 331 nM 1.76717251640721 0.0317841510275387 no 158 0.0385996704715767 297 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1919 st067113 52.3 µM 1.76381796697858 0.0320366002291873 no 159 0.0388813157713696 332 1268243 SGTC_2175 5807670 165.306 µM 1.75671030982984 0.0325769646956191 no 160 0.039483599665542 278 241186 SGTC_288 1315-0019 35.1 µM 1.75616358378347 0.032618839432933 no 161 0.0395302403849381 300 6811474 SGTC_538 2922-0838 53.3 µM 1.7545367875417 0.0327437013300484 no 162 0.0396692860525267 358 777039 SGTC_736 0958-0254 92.6 µM 1.75319132041239 0.0328472678137582 no 163 0.0397845861881158 336 6812352 SGTC_3004 9076122 71.4286 µM 1.73531406694753 0.0342491667202302 no 164 0.0413425957471291 327 44782551 SGTC_1288 0973-0013 65.5 µM 1.73322105606303 0.034416465852699 no 165 0.0415281929535585 311 4315430 SGTC_766 1391-0721 126 µM 1.73101112884558 0.0345938385881317 no 166 0.0417248897926633 310 1020919 YIL115C NUP159 SGTC_1897 st060201 15 µM 1.73008903151692 0.034668069459009 no 167 0.0418071848071052 273 611878 SGTC_1212 0520-0165 585 µM 1.72700451589526 0.0349173310082809 no 168 0.0420834262271261 324 5403258 SGTC_2815 7968870 71.43 µM 1.71080920498514 0.0362503324273185 no 169 0.0435581698812746 367 2977326 YHR190W ERG9 SGTC_576 1073-0113 22.7 µM 1.70934376445879 0.0363729779474846 no 170 0.0436936455454515 481 5439563 SGTC_902 1120-0002 2.07 µM 1.7084316628709 0.0364494847990338 no 171 0.0437781381743432 377 3280475 SGTC_1637 st007924 17.4 µM 1.70818546081659 0.0364701587211486 no 172 0.0438009677062793 315 683336 SGTC_277 nystatin 15.5 µM 1.7052627445765 0.0367163170400827 no 173 0.0440727162720876 340 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2395 5646831 180.19 µM 1.6963642602299 0.0374741473638149 no 174 0.0449084588710124 338 6808628 SGTC_833 3852-0053 558 µM 1.69009551582931 0.0380156504150013 no 175 0.0455048413207432 353 3123681 SGTC_732 3970-1727 52.7 µM 1.68942736989134 0.0380737403608326 no 176 0.0455687797932655 281 1275699 SGTC_676 falcarinol 140 µM 1.68828661192832 0.0381730874715347 no 177 0.0456781119764115 358 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_441 propafenone 146 µM 1.6813536165998 0.0387814287147916 no 178 0.0463471246242459 269 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2038 4100038 30.985 µM 1.68133147230745 0.0387833843616967 no 179 0.0463492740159469 359 3596803 SGTC_2677 mitomycin C 100 µM 1.67745201467639 0.0391272358288679 no 180 0.0467270626731404 261 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1416 3966-0321 25.3 µM 1.67603387373468 0.039253548915743 no 181 0.0468657788933437 340 582530 YLR208W SEC13 SGTC_825 1988-2224 89.6 µM 1.67039370584932 0.0397592040684096 no 182 0.0474207470684559 366 1180859 SGTC_445 e6 berbamine 66 µM 1.65457519272557 0.041205678531059 no 183 0.0490053495177276 493 6610268 A calcium/calmodulin antagonist. SGTC_136 0097-0015 404.482 µM 1.65084042485201 0.0415533455348955 no 184 0.0493855816228182 375 4861337 SGTC_1614 st002383 48.6 µM 1.6460560849851 0.0420021847064088 no 185 0.0498761063135824 348 1947235 SGTC_323 4013-0906 34.3 µM 1.64530926569651 0.042072599800702 no 186 0.0499530250129896 302 2910086 SGTC_594 1487-1584 10.8 µM 1.6448971684557 0.0421114959611534 no 187 0.0499955094798865 356 5013332 SGTC_3162 9099653 49.47 µM 1.62501979979639 0.0440224601630543 no 188 0.052079170013138 281 25237511 SGTC_3354 9151612 71.43 µM 1.62432396913298 0.0440906020604564 no 189 0.0521533421425202 374 27261949 SGTC_1822 st052468 42 µM 1.62303301493527 0.044217248955381 no 190 0.0522911737314386 312 2873678 SGTC_2439 5492030 7.2 µM 1.61488609866841 0.0450232673996148 no 191 0.0531676816064543 335 5722370 SGTC_1224 0823-0416 294 µM 1.61102399034671 0.0454094769162946 no 192 0.0535872468266443 353 3598164 SGTC_2362 9071156 126 µM 1.61040263448419 0.045471860384021 no 193 0.0536549929183016 367 653133 SGTC_1050 3232-1156 69.3 µM 1.60993668761209 0.0455186861583026 no 194 0.0537058393492294 364 700529 SGTC_2024 5144227 134 µM 1.60748270098193 0.0457659420947116 no 195 0.0539742606065338 414 3475211 SGTC_48 0382-0018 55 µM 1.60031357143699 0.0464944688271859 no 196 0.0547645188183604 322 762596 SGTC_2382 9035899 200 µM 1.60012714268183 0.0465135371690436 no 197 0.0547851903615586 375 6462679 SGTC_798 1287-0182 476 µM 1.59300407158293 0.0472468138721769 no 198 0.0555796388257313 420 1649755 SGTC_865 0488-0499 301 µM 1.5927923430328 0.0472687510215028 no 199 0.0556033917143831 390 9634651 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.58966268767636 0.0475939670533033 no 200 0.05595542923301 364 4213774 SGTC_2708 st078559 56 µM 1.58643504381162 0.0479312402805281 no 201 0.0563203280946557 266 17250902 SGTC_365 0121-0052 13.6 µM 1.58415250525734 0.0481709074279047 no 202 0.0565795092148492 470 3101739 SGTC_2751 anetholtrithion 17.25 µM 1.58026234515965 0.0485815840720983 no 203 0.0570233996829589 396 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2692 st077426 47.7 µM 1.57779619121191 0.0488433777027808 no 204 0.0573062195662521 388 25238571 SGTC_301 4119-0100 24.5 µM 1.57322958498444 0.0493311196707257 no 205 0.0578328336085374 447 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_702 1488-0190 94 µM 1.57191206521259 0.0494725594784785 no 206 0.0579854730213408 351 949357 SGTC_1341 1486-1360 280 µM 1.56451931003221 0.050272208199381 no 207 0.058847830883993 406 3976547 SGTC_627 1391-0720 175 µM 1.56291065955728 0.0504475677365976 no 208 0.0590368050348853 376 997839 SGTC_3329 9141233 27.5565 µM 1.55949806536811 0.05082118933145 no 209 0.0594392710560826 356 4909101 YNL103W MET4 SGTC_1328 1441-0025 69.2 µM 1.55921140947854 0.0508526733674221 no 210 0.0594731756452357 340 4562601 SGTC_3347 9188721 44.724 µM 1.55878498215085 0.0508995375330927 no 211 0.0595236399247917 343 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2519 cryptotanshinone 88.04 µM 1.55575930583872 0.0512330461633195 no 212 0.0598826691042082 332 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1531 st059297 52.4 µM 1.5543356587661 0.0513905696275063 no 213 0.0600521859775229 398 7566702 SGTC_138 0850-0259 40.9225 µM 1.55085054688785 0.051777815699523 no 214 0.0604687519867756 574 6813004 SGTC_2587 piperic acid 92.2 µM 1.54803886613049 0.0520919212488232 no 215 0.0608064696386009 371 5370536 SGTC_817 1391-0715 46 µM 1.54485050211411 0.0524499371720402 no 216 0.0611912142212208 363 1353946 SGTC_3185 9108267 49.47 µM 1.54484748778145 0.0524502765681583 no 217 0.0611915788632033 409 4910486 SGTC_450 aminopyrene 156 nM 1.54410363750786 0.052534083044421 no 218 0.0612816138994618 416 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2025 5147754 141 µM 1.54313019691641 0.0526439170117386 no 219 0.0613995946788979 354 315777 YLR208W SEC13 SGTC_731 3966-0296 387 µM 1.54122123320384 0.0528598357148931 no 220 0.0616314757285004 391 660956 SGTC_2435 5706476 10.6 µM 1.53766426458975 0.053264030108118 no 221 0.0620653627359025 433 5725375 SGTC_1278 0874-0585 172 µM 1.53729376626536 0.0533062720076119 no 222 0.0621106936638343 382 766306 SGTC_1273 0849-0096 14.1 µM 1.53585917008053 0.0534700861954129 no 223 0.062286461963145 422 5286025 SGTC_3136 9095672 49.47 µM 1.53057531600923 0.0540768834454728 no 224 0.0629371930820588 339 17217380 SGTC_1971 st069429 63.5 µM 1.52889143420801 0.0542714013831959 no 225 0.0631456800486021 355 1246522 YGL099W LSG1 SGTC_1773 st048542 73.5835 µM 1.52380870562278 0.0548619047801841 no 226 0.0637782521128253 436 3237138 SGTC_1127 asiatic acid 681.4 nM 1.52360906313393 0.0548852021707841 no 227 0.0638031989063544 419 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2065 5221596 34.26 µM 1.52044011761941 0.0552560520779802 no 228 0.0642001990954874 402 788581 SGTC_579 4491-1009 110 µM 1.51798193530021 0.0555450847812768 no 229 0.0645094763646735 532 1271041 SGTC_2229 7354935 190 µM 1.51524609371647 0.0558681664947859 no 230 0.0648550470511615 323 318112 SGTC_1500 4488-1866 171 µM 1.51494971664932 0.0559032551552081 no 231 0.0648925692662351 462 2900003 SGTC_690 glyoxal 20.3 µM 1.51315823901671 0.0561157219809461 no 232 0.0651197345709582 457 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3111 9122088 49.47 µM 1.51108845438486 0.0563619879363892 no 233 0.0653829579513767 284 16876704 SGTC_2935 9038016 29.96 µM 1.50845354935215 0.0566767243444332 no 234 0.0657192432885871 434 6463195 SGTC_1653 st012112 65 µM 1.50590601668727 0.0569823390974947 no 235 0.0660456509021942 388 720429 SGTC_2125 5246583 200 µM 1.50563801576618 0.0570145651139398 no 236 0.06608006193402 496 835267 SGTC_551 k048-0028 34.9 µM 1.50306126273101 0.0573251418239769 no 237 0.0664116234196677 450 6836383 SGTC_139 0099-0334 718.624 µM 1.50027769803726 0.0576621397573424 no 238 0.0667712419771015 508 97690 SGTC_1950 st077106 7.18 µM 1.50025955221085 0.0576643417188796 no 239 0.0667735912340305 431 13831864 SGTC_1505 k297-0037 20.6 µM 1.49922594630685 0.0577898770229281 no 240 0.0669075130558598 438 4089396 SGTC_1348 1493-0373 93.8 µM 1.49861946320848 0.0578636366292874 no 241 0.0669861902797226 398 3010129 SGTC_1876 myriocin 605 nM 1.48940961954952 0.0589928427914069 no 242 0.0681897685013621 423 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1334 1486-0610 236 µM 1.4881244187965 0.0591517847868781 no 243 0.0683590424067676 445 3742339 SGTC_1705 st027868 56.3335 µM 1.48787294062481 0.0591829245838003 no 244 0.0683922025161164 380 292948 SGTC_1795 st049545 62.3 µM 1.48493413990874 0.0595477812780037 no 245 0.0687806356405651 412 5291882 SGTC_3064 1327-0027 10 µM 1.48440913894283 0.0596131461707037 no 246 0.0688502058635129 265 16000455 YPR107C YTH1 SGTC_1646 st011709 75.6 µM 1.47695780343828 0.0605469439602516 no 247 0.0698434743554334 376 5757843 SGTC_890 0929-0006 47.2 µM 1.47675541570224 0.0605724658196146 no 248 0.0698706058194742 401 1378169 SGTC_2270 7924575 90.91 µM 1.47537983245208 0.0607461551324196 no 249 0.0700552271464976 454 1262135 SGTC_540 1187-0821 17.3 µM 1.47377262373889 0.0609495839898164 no 250 0.0702714108016587 425 847520 SGTC_503 tyrphostin 8 294 µM 1.47361334619033 0.0609697731615597 no 251 0.0702928629378543 441 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2329 6138490 200 µM 1.47232293507909 0.0611335315933506 no 252 0.0704668463763723 405 720019 SGTC_1252 0493-0875 34.8 µM 1.47102690276547 0.0612983491723571 no 253 0.070641920741079 437 3960963 SGTC_2755 lomerizine 42.69 µM 1.47094112170097 0.0613092702642432 no 254 0.070653520250126 460 3949 A calcium channel blocker. SGTC_318 1488-0629 67.2 µM 1.4667150545741 0.0618491905083693 no 255 0.0712267929010767 405 3662576 SGTC_887 0885-0007 9.62 µM 1.46536702349931 0.0620221928119688 no 256 0.071410404698725 468 5719458 SGTC_3291 9121177 71.43 µM 1.46477879077432 0.062097803086829 no 257 0.071490640100179 372 17015612 SGTC_2466 5983409 37.09 µM 1.45434871253979 0.0634504403722129 no 258 0.0729248257369065 433 2879657 SGTC_148 3253-0744 288.01 µM 1.45074176734127 0.0639235112566459 no 259 0.0734258901786801 417 6893655 SGTC_1454 4239-0054 42.6 µM 1.44787442478026 0.064301532408871 no 260 0.0738260867313194 504 1340767 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.44785520166275 0.0643040725722881 no 261 0.0738287753264468 488 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1270 0831-1170 17.3 µM 1.44576740813328 0.0645804203164007 no 262 0.0741212251911115 488 6764716 SGTC_1029 k015-0030 64.7 µM 1.44511135138235 0.0646674485318054 no 263 0.0742133055149936 443 2208316 SGTC_219 mitoxanthrone 164.414 µM 1.44426261742742 0.0647801711556338 no 264 0.0743325584846594 460 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_22 0964-0034 14.468 µM 1.44193802578629 0.0650896876233343 no 265 0.0746599288369384 501 138402 SGTC_2525 harmine 47.85 µM 1.4366479278761 0.0657983345321146 no 266 0.0754090289320593 383 5280953 A monoamine oxidase inhibitor SGTC_2137 5261020 140 µM 1.42993622254301 0.0667060051652546 no 267 0.0763676623094013 449 763655 SGTC_2342 7990637 118.86 µM 1.4288463919313 0.0668543006328725 no 268 0.0765241941314149 491 2033102 YER133W GLC7 SGTC_429 1112-0049 25.5 µM 1.42586532453912 0.0672612436286715 no 269 0.0769536101453722 436 2836170 SGTC_892 0929-0076 29 µM 1.42565426128648 0.0672901281302348 no 270 0.0769840826210459 523 5751038 SGTC_2688 kanamycin b 96.69 µM 1.42400128743496 0.0675166732129333 no 271 0.077223049693355 997 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2902 5787006 60.46 µM 1.41955640470237 0.0681287813275176 no 272 0.0778684324292727 448 591003 SGTC_807 1315-0151 48 µM 1.4182072828665 0.0683154148282719 no 273 0.0780651281299985 533 4011080 SGTC_725 1497-0963 19 µM 1.41765248927475 0.0683922777055006 no 274 0.0781461237465586 468 3549977 SGTC_221 trifluoperazine 10.304 µM 1.41650357458396 0.0685516641681425 no 275 0.0783140591624995 652 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.41140251196933 0.0692627857144156 no 276 0.0790629813568264 468 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1320 1313-0481 95.3 µM 1.40759818227313 0.0697968237219079 no 277 0.0796250430051335 475 6813365 YLR208W SEC13 SGTC_1090 efavirenz 20.7 µM 1.407130448779 0.0698627006378147 no 278 0.0796943553477281 477 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3305 9127027 53.8275 µM 1.40562696924223 0.0700747791046518 no 279 0.079917461664409 476 41905295 SGTC_3084 9116877 49.47 µM 1.40539481567629 0.0701075704180028 no 280 0.0799519537574113 393 27241325 SGTC_683 panaxydol 45 µM 1.40493494349501 0.0701725614636492 no 281 0.080020312255682 494 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1873 rapamycin 2 nM 1.40475345916443 0.0701982223314088 no 282 0.0800473014660521 535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2541 muurolladie-3-one 83.07 µM 1.40245685516506 0.0705235731352649 no 283 0.0803894328237491 473 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3225 9130819 49.47 µM 1.40111915681917 0.0707136130583729 no 284 0.0805892219608045 476 4547121 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.39998996523846 0.0708743375802529 no 285 0.0807581617237393 475 688669 SGTC_2464 5717415 7.67 µM 1.3978742212546 0.0711762392819552 no 286 0.0810754205538758 508 5285744 SGTC_622 1348-1566 26.3 µM 1.39414912629137 0.0717101823629116 no 287 0.0816362884187057 532 7340407 SGTC_863 0466-0191 129 µM 1.39190093934414 0.0720339138073485 no 288 0.0819761986859736 546 765160 YPR165W RHO1 SGTC_2807 7945238 51.95 µM 1.38870864279935 0.0724955174016802 no 289 0.08246068249538 505 17148797 SGTC_3310 9130229 44.1445 µM 1.38744276889332 0.0726791879495189 no 290 0.0826533955740121 472 7761258 SGTC_858 0438-0351 2.77 µM 1.38591847770853 0.0729008259142188 no 291 0.082885898954522 513 2799119 SGTC_1438 4092-1045 4 µM 1.38323596890238 0.0732921292631233 no 292 0.0832962620864838 495 1351342 SGTC_2953 9074162 66.49 µM 1.38308904923015 0.0733136070728873 no 293 0.0833187815097794 443 16451992 SGTC_164 4100-3994 89.624 µM 1.3788447269574 0.0739361543385777 no 294 0.0839713165293304 554 4615967 SGTC_1457 k015-0032 57.3 µM 1.37106531458722 0.0750876964248154 no 295 0.0851772981547796 503 4302660 SGTC_3042 9091578 49.47 µM 1.37005740504753 0.0752378868893763 no 296 0.0853344914119397 438 25236497 SGTC_1200 1643-0193 18.4 µM 1.36779658771836 0.0755756083702995 no 297 0.085687878056954 533 5403974 SGTC_2249 haloperidol 116.36 µM 1.36693901409013 0.0757040146735331 no 298 0.0858222109749122 638 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1231 0242-0792 125 µM 1.36460790395882 0.0760538965530376 no 299 0.0861881596078317 497 3707635 SGTC_2974 9094440 9.66 µM 1.36453866408703 0.076064307724842 no 300 0.0861990470303094 550 25236134 SGTC_3054 9094397 49.47 µM 1.36025624400089 0.0767103397638074 no 301 0.0868744248580371 536 2598354 SGTC_2783 7738165 71.43 µM 1.35942695754167 0.0768359240607507 no 302 0.0870056668052325 408 17201110 SGTC_2847 9005661 71.43 µM 1.35732176897548 0.0771554285948875 no 303 0.0873394966744934 354 2991449 SGTC_3106 9121286 49.47 µM 1.35665234826606 0.0772572378545659 no 304 0.087445850048799 448 15943471 SGTC_3031 9088762 49.47 µM 1.35626611531718 0.0773160247417505 no 305 0.0875072562809122 512 205253 SGTC_3255 9139072 49.47 µM 1.3524860567507 0.0778931663907539 no 306 0.0881099381363612 514 17646060 SGTC_408 cantharidin 100 µM 1.34865961681019 0.0784807134157957 no 307 0.0887231611068045 545 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_769 0302-0231 76 µM 1.34320248211772 0.0793244567687182 no 308 0.0896032090863666 610 571869 YER009W NTF2 SGTC_278 4092-0821 23.9 µM 1.33934356539716 0.0799252272125023 no 309 0.090229426164492 508 877900 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.33609297786447 0.0804339552310263 no 310 0.0907594424670019 597 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2921 7974240 10.71 µM 1.33479594074709 0.0806376274157504 no 311 0.0909715712106136 521 2979074 YDR527W RBA50 SGTC_767 0929-0023 86 µM 1.33422947050533 0.0807267016679653 no 312 0.0910643319928818 619 1204563 SGTC_2670 beta-carotene 100 µM 1.32998065178039 0.0813971745605257 no 313 0.091762323111484 431 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_99 0109-0120 622.8 µM 1.32954724535368 0.0814658024226825 no 314 0.0918337447805001 474 759414 SGTC_33 0986-0033 35.816 µM 1.32722181352818 0.0818347689533861 no 315 0.0922176593076331 488 2848082 SGTC_1790 st045711 43.5 µM 1.32486021133344 0.0822107620739832 no 316 0.0926087599105901 518 585119 SGTC_728 3030-5151 22.5 µM 1.32451005036075 0.0822666221515518 no 317 0.0926668537191779 487 3125388 SGTC_3328 9140624 29.0385 µM 1.32236986102184 0.0826086612550632 no 318 0.093022509918606 535 4904392 SGTC_891 0929-0073 133 µM 1.31565014110591 0.0836895448101151 no 319 0.0941457479815836 529 5603632 SGTC_1450 4112-4260 37.6 µM 1.3131890370271 0.0840880665758385 no 320 0.0945596285967819 555 1633175 SGTC_2311 7694451 200 µM 1.31109173367081 0.0844288017454649 no 321 0.0949133866047664 543 2163142 SGTC_745 0469-0705 296 µM 1.3024928489652 0.085836641935907 no 322 0.096373980470341 617 3486736 SGTC_1153 4055-0057 267 µM 1.30090574641916 0.0860983978558057 no 323 0.0966453594637615 552 882706 SGTC_349 k015-0014 24 µM 1.29861335465906 0.0864775284932941 no 324 0.0970383262761132 523 2196908 SGTC_797 k781-0471 270 µM 1.29781445011165 0.08660994938561 no 325 0.0971755514649299 556 23738129 SGTC_1171 0368-0077 21.4 µM 1.29663540044018 0.0868056573233786 no 326 0.0973783330132141 508 3239779 SGTC_2834 9001755 58.44 µM 1.29441713151603 0.0871747584060851 no 327 0.0977606881521366 483 2989575 SGTC_1020 4335-0961 93.3 µM 1.28734821578372 0.088358783475124 no 328 0.0989864724987451 513 669075 SGTC_1445 4239-0156 97.7 µM 1.28662382793793 0.0884807902673164 no 329 0.099112717177459 635 4008346 SGTC_2777 climbazole 1.536 µM 1.28553599568409 0.0886642467812122 no 330 0.0993025232663708 593 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1712 st032288 53.4 µM 1.28347565584742 0.0890124871568851 no 331 0.0996627415499508 725 2883011 SGTC_1174 0739-0097 51.1 µM 1.28328206859636 0.0890452596873737 no 332 0.0996966362661036 579 728447 SGTC_1860 st056228 74.6 µM 1.27929159000272 0.0897228128096414 no 333 0.100397196517496 541 688679 SGTC_2339 9000433 200 µM 1.27832621616552 0.089887300281643 no 334 0.100567213921542 507 2988954 SGTC_184 1494-0393 24.714 µM 1.27507843850636 0.0904423257814333 no 335 0.101140740093831 583 3090647 SGTC_604 1000-0114 314 µM 1.27251679621836 0.0908818868432144 no 336 0.101594780095041 594 1572745 SGTC_1938 st074717 56.4 µM 1.27184517743659 0.090997394061164 no 337 0.101714066830598 504 17250979 SGTC_1059 3448-6867 171 µM 1.27128732180237 0.0910934186791609 no 338 0.101813225503144 562 3934407 SGTC_1052 3253-3998 198 µM 1.26931862533191 0.0914328942717855 no 339 0.102163723032018 613 5450317 SGTC_150 3970-0969 77.2 µM 1.26519370853426 0.0921472206179201 no 340 0.102900948615195 653 6615640 SGTC_289 k017-0060 526 µM 1.26241407770708 0.0926309037537677 no 341 0.103399913100161 536 5512909 SGTC_1040 k898-0338 155 µM 1.26236091328854 0.0926401731539337 no 342 0.103409473597233 614 20969351 SGTC_199 4063-0024 41.6 µM 1.25767875972882 0.0934592161817158 no 343 0.104253978426548 568 306215 SGTC_2061 5245884 80.95 µM 1.25741754915483 0.0935050664235996 no 344 0.104301238917831 596 573863 SGTC_1512 0259-0544 12.2 µM 1.25555339783576 0.0938327629696758 no 345 0.104638968272789 618 18476 SGTC_1393 3470-5649 58.2 µM 1.25048448433804 0.0947281053058045 no 346 0.105561309838878 465 4108395 SGTC_1520 flindersine 88 µM 1.24825015681581 0.09512475669927 no 347 0.105969730554752 603 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2946 9065502 71.43 µM 1.24707984950502 0.0953330042644919 no 348 0.106184110346662 411 16489101 SGTC_236 1509-0011 5.31 µM 1.24592597480554 0.0955386561757465 no 349 0.106395786516139 872 3107280 SGTC_1246 0422-0085 105 µM 1.24533932813471 0.0956433377040302 no 350 0.106503522521344 641 264295 SGTC_1824 st053723 68.6 µM 1.24514197682104 0.0956785721366077 no 351 0.106539783231311 585 675225 SGTC_332 4112-0506 40.9 µM 1.24474124257904 0.0957501472492166 no 352 0.106613440301405 583 2790355 SGTC_1948 st076329 66.6 µM 1.2401894297922 0.0965659126112583 no 353 0.10745266855823 540 24208413 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.23631251139762 0.0972647417029855 no 354 0.108171211131338 578 390807 SGTC_1374 2889-5571 141 µM 1.2353309045284 0.097442267281458 no 355 0.108353688239858 634 2853281 SGTC_1708 st033234 31.827 µM 1.23502529132262 0.0974975865318871 no 356 0.1084105458043 627 674664 SGTC_410 α-linolenic acid 100 µM 1.23487581053671 0.0975246525356369 no 357 0.108438363654215 614 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.23105500075403 0.0982183459208334 no 358 0.109151147064298 582 229346 A bile salt which induces apoptosis. SGTC_733 4069-0007 56.1 µM 1.23050248122721 0.0983189578913914 no 359 0.109254499214829 667 5717425 YNL287W SEC21 SGTC_1199 1638-0010 4.46 µM 1.23003607644851 0.0984039473876769 no 360 0.109341797786636 628 3111136 SGTC_1568 digitonin 820 nM 1.22628833048099 0.0990888250972645 no 361 0.1100450955958 655 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2863 9028737 58.44 µM 1.22596206514486 0.0991486126534228 no 362 0.110106475404557 551 6460917 SGTC_3170 9103054 49.47 µM 1.21707925892749 0.100786521981916 no 363 0.111787030652184 558 16432970 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.21646479709315 0.100900548580038 no 364 0.111903956646667 641 5106787 A p450 inhibitor. SGTC_514 4466-0038 2.65 nM 1.21513305906968 0.101148003961328 no 365 0.112157673308059 680 5722064 SGTC_1216 1165-0504 9.65 µM 1.212467828299 0.101644568475286 no 366 0.112666675220766 639 6304004 SGTC_347 4534-1311 26.2 µM 1.20768141253422 0.102540787162506 no 367 0.113584915182079 616 2862016 SGTC_2667 digitoxin 100 µM 1.20603484547594 0.102850418060498 no 368 0.113902027515546 514 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1218 1348-1416 30.7 µM 1.2049481776834 0.103055133724032 no 369 0.114111654108382 614 6787668 SGTC_2231 micatex 6.853 µM 1.20288711389328 0.103444227050347 no 370 0.114510003794905 585 20737 An antifungal of unknown mechanism. SGTC_813 k007-0158 173 µM 1.20036666379044 0.103921492498347 no 371 0.114998484890131 690 6523916 SGTC_1436 4092-1007 8.32 µM 1.19977631241082 0.104033510264103 no 372 0.115113113062151 594 2881121 SGTC_1917 st066507 28.5 µM 1.19709128984436 0.10454409157741 no 373 0.115635487278994 651 3156428 SGTC_1410 3909-8106 77.9 µM 1.19705466060547 0.104551069487532 no 374 0.115642625163259 605 1039210 SGTC_151 3013-0144 2.285 µM 1.196856726865 0.104588781919631 no 375 0.115681201626571 640 906558 YHR107C CDC12 SGTC_1430 4049-0248 69.1 µM 1.19649787107922 0.104657180049617 no 376 0.115751164434604 688 22774488 SGTC_1064 honokiol 6.76 µM 1.1934308006094 0.105243087637358 no 377 0.116350349131829 633 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_308 4092-1169 104 µM 1.19152897076627 0.105607587410455 no 378 0.116722995229164 670 2268590 YDL196W YDL196W SGTC_1701 st028638 40.4 µM 1.19083010490641 0.10574175931762 no 379 0.116860143958223 624 3490878 SGTC_1720 st037298 9.481 µM 1.1903395061592 0.105836020608805 no 380 0.116956489580637 589 597396 SGTC_1713 st033146 12.748 µM 1.18715224576094 0.10644988480236 no 381 0.117583786685792 641 674619 SGTC_173 1273-0061 2.693 µM 1.18642686234456 0.106589951557514 no 382 0.117726884314877 654 2847414 YPL266W DIM1 SGTC_137 0438-0332 85.389 µM 1.18641986571428 0.106591303208161 no 383 0.117728265151979 746 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_602 3130-1533 38.1 µM 1.18598386008039 0.106675557779817 no 384 0.117814336725924 694 720941 SGTC_205 1486-1330 71.903 µM 1.18451659159179 0.106959448610221 no 385 0.118104316226959 566 4118834 SGTC_376 3970-0862 59.1 µM 1.18361392938254 0.107134368536676 no 386 0.118282961945257 637 3135186 SGTC_1193 1488-0126 41.5 µM 1.18259302810671 0.10733244958511 no 387 0.11848523846751 642 1384710 SGTC_1798 st045719 60.953 µM 1.18171494202503 0.107503031906898 no 388 0.118659413737167 576 3980186 SGTC_80 0159-0065 512.242 µM 1.18165041251385 0.107515575503026 no 389 0.118672220804434 517 1548079 SGTC_2469 5655019 90.81 µM 1.17767167673026 0.10829102232677 no 390 0.119463761299543 672 2788239 SGTC_334 1502-1024 68.5 µM 1.17696786896517 0.10842861083388 no 391 0.11960416555616 657 3296216 SGTC_1470 k295-0292 231 µM 1.17367465232538 0.1090740782676 no 392 0.120262683436833 670 5045612 SGTC_364 0083-0097 67.7 µM 1.17307219426463 0.109192457679091 no 393 0.120383427959609 647 5207356 SGTC_2041 5107442 45.335 µM 1.17176298076807 0.109450028537606 no 394 0.120646114601307 658 793005 SGTC_1413 3910-0535 34.4 µM 1.17129957065562 0.109541302978547 no 395 0.12073919197656 665 2876951 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.16955810059354 0.109884796009398 no 396 0.121089423553008 731 368090 SGTC_2647 atorvastatin 60.16 µM 1.16662602171074 0.110464873595658 no 397 0.121680714996714 625 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1362 1611-0397 101 µM 1.16523366897057 0.110741101804827 no 398 0.121962210228203 652 27816 SGTC_1140 3229-1848 2.98 µM 1.16403069414651 0.110980157684165 no 399 0.122205786522548 654 2849525 SGTC_2127 5253358 187.912 µM 1.16172023423904 0.111440329894423 no 400 0.122674561916875 578 20612 SGTC_2648 atorvastatin 78.68 µM 1.15326069390276 0.113136858527925 no 401 0.12440169910132 638 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1856 st057054 55.7 µM 1.15306831675478 0.113175652175303 no 402 0.124441172422746 693 1266018 SGTC_1972 st070201 17.4 µM 1.15122254607802 0.113548341894085 no 403 0.124820346022081 666 2829099 SGTC_1001 4048-4355 44.4 µM 1.14934021558138 0.113929313998373 no 404 0.125207860728823 654 21824233 SGTC_2096 5468907 200 µM 1.14813398388317 0.114173926188495 no 405 0.125456628422554 649 759785 SGTC_1345 1488-0192 31.4 µM 1.14664225531439 0.11447695143266 no 406 0.125764752511321 674 658348 SGTC_2505 galangin 7.89 µM 1.14140527631145 0.115545307189076 no 407 0.12685065500995 582 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1455 4262-0120 131 µM 1.13956660133417 0.115922076023346 no 408 0.127233453184533 698 1529587 SGTC_1980 st071811 45.7 µM 1.13906920987884 0.116024147849152 no 409 0.127337144273164 658 4974850 SGTC_1169 aniline yellow 25.8 µM 1.13552049767854 0.116754245926791 no 410 0.128078649258398 641 6051 A DNA damaging agent. SGTC_1318 1280-3875 124 µM 1.13519602656025 0.116821163495689 no 411 0.12814659699327 698 373245 SGTC_2160 5660466 132.927 µM 1.13408267322711 0.11705098352092 no 412 0.128379935452793 650 2859134 SGTC_328 k915-0120 63.5 µM 1.13286585914068 0.117302526264086 no 413 0.128635294567091 666 6624543 SGTC_837 0091-0265 12.5 µM 1.13089997218713 0.117709727668635 no 414 0.129048597510409 711 759367 SGTC_144 4161-2749 112.381 µM 1.12965035824016 0.11796908431184 no 415 0.129311791259754 602 797501 YMR168C CEP3 SGTC_16 erodoxin 22.806 µM 1.12935788838502 0.118029844595119 no 416 0.129373444962433 727 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1984 st072354 53.1 µM 1.12851209637616 0.118205681492905 no 417 0.129551855599545 678 5762938 SGTC_7 0192-1582 4.227 µM 1.12713188810816 0.118493019093987 no 418 0.129843361413601 792 252616 SGTC_871 0574-0004 149 µM 1.1260887078632 0.118710520079253 no 419 0.130063986617368 729 9551173 SGTC_37 0566-0070 1.56 µM 1.11963583146133 0.12006220097308 no 420 0.13143448994688 734 1626686 SGTC_2515 chrysin 20.77 µM 1.11653880861657 0.120714770744432 no 421 0.13209578392962 698 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3033 9090887 49.47 µM 1.11626015060866 0.120773608619918 no 422 0.132155396878908 704 19325384 SGTC_2113 5491891 107.031 µM 1.11519607914334 0.120998470094977 no 423 0.132383202949511 701 789979 SGTC_2933 9026794 32.47 µM 1.11424336478205 0.121200049182362 no 424 0.132587398186372 712 17586027 SGTC_97 0535-0701 19.132 µM 1.11204292770764 0.121666528826808 no 425 0.133059846793395 651 2832013 YGL099W LSG1 SGTC_1818 st052136 56.3 µM 1.11175841924091 0.121726934927842 no 426 0.133121017163699 664 674169 SGTC_350 k064-0020 19.8 µM 1.11101896222092 0.12188403308168 no 427 0.133280093664132 748 2790705 SGTC_1237 0330-0133 46.1 µM 1.10873043899502 0.122371133694031 no 428 0.133773243276252 667 X1237 YHR072W ERG7 SGTC_2210 7115885 190.385 µM 1.1076738005079 0.122596494290583 no 429 0.134001359081508 719 2927039 SGTC_911 3456-4043 236 µM 1.10658308588445 0.122829427907959 no 430 0.134237111731317 724 914281 SGTC_1088 bifonazole 369 nM 1.10613846293794 0.122924470819577 no 431 0.134333296498405 704 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1647 st011722 22.4 µM 1.10424940456817 0.123328852148013 no 432 0.134742481938057 661 2854783 SGTC_1821 st053465 65.6 µM 1.10094464650538 0.124038524912506 no 433 0.135460374563273 671 675086 SGTC_1385 3091-4834 14.1 µM 1.09996507896646 0.12424942787359 no 434 0.135673668715681 656 4072814 SGTC_718 1130-0073 349 µM 1.09721532532969 0.12484279550468 no 435 0.136273637672876 730 6740020 SGTC_1253 0550-0034 176 µM 1.09680919402803 0.124930601860557 no 436 0.136362405122957 663 5969915 SGTC_856 0433-0016 11.3 µM 1.09590999686561 0.125125163473265 no 437 0.136559081892171 730 3911780 SGTC_1276 0871-0068 94.2 µM 1.09539593981918 0.125236486340933 no 438 0.136671606057339 699 3414906 SGTC_459 nigericin 15.3 µM 1.09526640740247 0.125264548451783 no 439 0.136699969964118 731 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1343 1487-0095 224 µM 1.09474528770465 0.125377489018077 no 440 0.136814120986295 703 4560101 YGL055W OLE1 SGTC_84 0443-0269 128.823 µM 1.09253708822089 0.125856853536428 no 441 0.137298548946752 736 6150058 SGTC_1465 k213-0056 144 µM 1.09066858893052 0.126263471854091 no 442 0.137709368463156 696 24048857 YMR208W ERG12 SGTC_1677 st019204 53.9 µM 1.08713542516957 0.12703485080361 no 443 0.138488481991307 671 3945625 SGTC_489 paxilline 115 µM 1.0868531048504 0.12709662966471 no 444 0.138550867031816 678 105008 A toxic potassium channel blocker. SGTC_869 0564-0080 44.1 µM 1.08472736420498 0.127562467109451 no 445 0.139021212208414 721 6843321 SGTC_730 1436-0052 41.2 µM 1.08238124489456 0.128077975207845 no 446 0.139541579257473 689 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3200 9114385 49.47 µM 1.08207907347312 0.128144475774294 no 447 0.139608696762237 666 17018030 YLR208W SEC13 SGTC_1522 st012842 45.6 µM 1.08089763000155 0.128404712857634 no 448 0.139871326500263 656 3491067 YOR116C RPO31 SGTC_2913 7966556 36.57 µM 1.08067345440183 0.128454133501005 no 449 0.139921197638587 689 2976516 SGTC_653 0203-0016 55.2 µM 1.08052491181572 0.12848688773661 no 450 0.139954249763627 740 295302 SGTC_1481 3346-2004 36 µM 1.07773417957361 0.129103333110389 no 451 0.140576200274299 744 2770522 SGTC_1414 3917-0015 5.4 µM 1.07480578998625 0.129752387200366 no 452 0.141230843834969 715 6618702 SGTC_1530 rhein 70.4 µM 1.0746837322996 0.129779489277357 no 453 0.141258174712017 779 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2550 chrysin dimethyl ether 71.87 µM 1.07353979899065 0.130033682403038 no 454 0.141514495902014 591 88881 An O-methylated flavonoid and antioxidant. SGTC_1709 st033179 39.1045 µM 1.07327300559903 0.130093016018004 no 455 0.14157432160352 762 573381 SGTC_223 busulfan 5 mM 1.0727773958226 0.130203287064566 no 456 0.141685502525668 640 2478 A DNA alkylator. SGTC_1955 wogonin 32.4 µM 1.07042209506624 0.130728215281911 no 457 0.142214679119471 720 5281703 A flavanone. SGTC_1565 sinapyl alcohol 95.1 µM 1.07008018629147 0.130804538258136 no 458 0.142291608408566 684 5280507 A phenol propionate derived from cinnamic acid. SGTC_1510 1123-0200 71.5 µM 1.06749235030982 0.131383209626124 no 459 0.142874783074489 811 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2066 5222451 176 µM 1.06473402998887 0.132001946763735 no 460 0.143498152946135 797 2281147 SGTC_2665 lovastatin 100 µM 1.06363240735868 0.132249619724805 no 461 0.14374762776963 716 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3278 9139605 49.47 µM 1.06255045955767 0.132493180910922 no 462 0.143992931704058 717 7958859 SGTC_1683 st010134 710 nM 1.05905372897914 0.13328245537912 no 463 0.144787655541107 734 3818134 SGTC_2301 7769476 200 µM 1.05704952575242 0.133736295413549 no 464 0.145244492576739 695 977820 SGTC_2958 9077254 16.72 µM 1.0527090827498 0.134722801702226 no 465 0.146237172300724 701 16457351 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.0519548221535 0.13489473983132 no 466 0.146410138834084 717 75037 A free radical scavenger. SGTC_58 0957-0393 9 µM 1.04306172254115 0.136933326244389 no 467 0.148459853607557 923 6997992 SGTC_2576 guaiol 23.12 µM 1.04218530469717 0.137135363309737 no 468 0.148662887422665 803 227829 SGTC_1383 3049-0032 20.7 µM 1.04183099574359 0.137217098497402 no 469 0.148745020453292 768 712864 SGTC_2456 5770359 74.46 µM 1.03933310341584 0.137794279031589 no 470 0.149324922134344 792 3118787 SGTC_2095 5432005 200 µM 1.03891998081588 0.137889897448492 no 471 0.149420976456114 723 783734 SGTC_2639 lactacystin 53 µM 1.03703753661809 0.138326167550835 no 472 0.149859181896802 795 3870 A proteasome inhibitor. SGTC_2361 9034121 116 µM 1.03554883198768 0.13867185123171 no 473 0.150206336886688 736 6496917 SGTC_3020 9089140 49.47 µM 1.03228248283476 0.13943237232232 no 474 0.150969902361653 742 17217859 SGTC_895 0964-0006 13.7 µM 1.03185335010828 0.139532499992687 no 475 0.151070411196444 764 6738897 SGTC_3353 9151644 39.2805 µM 1.03053859921484 0.139839569457731 no 476 0.151378621204296 772 4909158 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.02942735400993 0.140099466647487 no 477 0.151639450323093 707 1241132 A phosphatase inhibitor. SGTC_38 0929-0051 58.268 µM 1.02937358404307 0.140112050644979 no 478 0.151652078667938 828 1379719 SGTC_2799 7812892 81.82 µM 1.02907602084795 0.140181704416857 no 479 0.151721976612477 813 20205235 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.02729426488931 0.140599270978475 no 480 0.152140961051551 821 676296 Flavone; oxidizing agent. SGTC_180 1486-1293 102.781 µM 1.02604663038714 0.140892164631595 no 481 0.152434802404379 787 4140536 SGTC_822 1487-0950 154 µM 1.02400188092862 0.141373082847899 no 482 0.15291719324594 773 1958375 SGTC_1048 3161-0300 24.5 µM 1.0235553703841 0.141478248462577 no 483 0.153022667105549 799 2165101 SGTC_202 3594-0513 34.79 µM 1.02348638126738 0.14149450203955 no 484 0.153038967881952 739 708429 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.02253865505618 0.141717910859626 no 485 0.153263013529808 801 23665772 A membrane-active detergent. SGTC_2699 st077704 54.6 µM 1.02105167939372 0.14206891899534 no 486 0.153614977343545 774 645852 SGTC_2187 6125751 200 µM 1.02045589521865 0.142209721854459 no 487 0.15375614818513 787 874498 SGTC_699 0375-0592 111 µM 1.02042416418552 0.14221722356037 no 488 0.153763669249787 823 762578 SGTC_2970 9090938 41.86 µM 1.017140145033 0.142995064587361 no 489 0.154543382517953 845 17217104 SGTC_1951 sophoraflavanone G 9.2 µM 1.01699170057928 0.143030292387283 no 490 0.154578688794728 787 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_396 dithiazanine 1.25 µM 1.01650617305641 0.14314555533685 no 491 0.154694204701647 738 10578 An antihelmenthic. SGTC_2376 9072922 81.32 µM 1.01421938803001 0.14368927561957 no 492 0.155239039636529 797 17087968 SGTC_377 3970-0964 33.1 µM 1.01277599830194 0.144033181519451 no 493 0.155583583802815 880 16481235 SGTC_1432 4049-0298 68.4 µM 1.01213428249085 0.144186256554951 no 494 0.155736926352463 778 741646 SGTC_276 colchicine 750 µM 1.01028350502593 0.144628355582703 no 495 0.156179740804304 810 2833 A microtubule depolymerizer. SGTC_2524 avocatin b 10.57 µM 1.00972664280041 0.144761552927684 no 496 0.156313137078133 739 6710748 SGTC_1910 st062352 60.4 µM 1.00959859789403 0.144792192004997 no 497 0.156343820828081 771 2245730 SGTC_1112 tnp00069 1.16933 µM 1.00906957444404 0.14491882505992 no 498 0.156470634210757 840 145826 SGTC_1019 4262-0212 3.4 µM 1.00854910182736 0.145043484035947 no 499 0.156595463935135 854 4677213 SGTC_2838 9002687 71.43 µM 1.0064146693601 0.145555459101573 no 500 0.157108070008376 735 6457060 SGTC_1203 3992-3522 103 µM 1.00639453556638 0.145560294267019 no 501 0.157112910595584 820 5322312 SGTC_791 1348-1292 225 µM 1.00462841859382 0.145984850613009 no 502 0.157537903901415 887 5437054 SGTC_717 1532-0246 73.2 µM 1.00399058961778 0.146138382431509 no 503 0.157691574733637 780 9561992 SGTC_167 3672-0051 66.205 µM 1.0037347105275 0.146200005561847 no 504 0.157753250826749 728 3237971 SGTC_1141 3253-0389 52.6 µM 1.00068443754971 0.14693594404184 no 505 0.15848969675783 801 5402031 SGTC_1770 st043884 66.3 µM 0.998433856173165 0.147480531388686 no 506 0.159034511641497 809 670149 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.998365895223116 0.147496997335081 no 507 0.159050982515138 832 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1567 st069303 68.4 µM 0.99779492679225 0.147635383294444 no 508 0.159189405365593 808 5581319 SGTC_126 0417-1624 672.48 µM 0.996983513620771 0.147832195553642 no 509 0.159386256193278 965 41912 YDL195W SEC31 SGTC_2766 oltipraz 83.91 µM 0.996492637612479 0.147951345189926 no 510 0.159505421258897 777 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1164 k060-0068 93.7 µM 0.996391776195469 0.147975835097403 no 511 0.159529913598435 844 5963676 SGTC_3260 9137109 49.47 µM 0.995870760631528 0.148102384787552 no 512 0.159656471842459 682 17478346 SGTC_1262 0737-0114 49.6 µM 0.995599812389905 0.148168224137143 no 513 0.159722312984287 882 765919 SGTC_2011 4012611 177 µM 0.995230713504158 0.148257945211041 no 514 0.159812033574236 808 2049887 SGTC_585 0kpi-0023 191 µM 0.994795998499473 0.148363662946658 no 515 0.159917746411146 763 64601 SGTC_507 nimesulide 162 µM 0.994292834916602 0.148486089537394 no 516 0.160040161483172 817 4495 A COX2 inhibitor. SGTC_1827 berberine 7.24 µM 0.992963699694297 0.148809811181438 no 517 0.16036382249232 733 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1731 st035964 63 µM 0.991830954037772 0.149086072556466 no 518 0.160639997565542 768 6739575 SGTC_1928 4'-methoxychalcone 40.3 µM 0.991432951004175 0.149183221401005 no 519 0.160737108514584 848 641818 SGTC_614 0462-0418 107 µM 0.991388622915698 0.149194044091675 no 520 0.160747926740755 740 5188303 SGTC_649 1123-0311 367 µM 0.990615136559672 0.149382974969302 no 521 0.160936771846762 854 693629 YIL048W NEO1 SGTC_2161 5662504 8.5105 µM 0.990496605685802 0.149411941289449 no 522 0.160965723707192 758 2859334 SGTC_2200 6600604 21.907 µM 0.9897358770966 0.149597935752731 no 523 0.161151617039062 824 2904777 SGTC_1258 0671-0043 57.1 µM 0.988418324170654 0.149920436450707 no 524 0.161473908456975 798 4298767 SGTC_2896 9052656 71.43 µM 0.986864080341513 0.150301468203474 no 525 0.161854637639344 881 6469436 SGTC_1737 st035557 69.7 µM 0.98675114534076 0.150329179991589 no 526 0.161882325090206 691 5716916 SGTC_2114 5491910 81.25 µM 0.983472348718085 0.151135209550169 no 527 0.162687508932784 810 2849228 SGTC_1071 trifluoperazine 6.31 µM 0.981465486096182 0.151629974408119 no 528 0.163181623185429 839 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3125 9127534 49.47 µM 0.980243224599892 0.15193183339282 no 529 0.163483036342518 710 1639235 SGTC_889 0919-1524 82.7 µM 0.979683490294879 0.152070202805301 no 530 0.16362118904196 772 3905452 SGTC_1030 k029-0042 36.7 µM 0.97942687282668 0.152133668032829 no 531 0.163684552277698 844 6080581 SGTC_34 0469-0683 81.75 µM 0.977906286970773 0.152510091849501 no 532 0.164060337700526 826 3690923 SGTC_485 niflumic acid 177 µM 0.977426516022707 0.152628988181804 no 533 0.164179020510086 791 4488 A COX2 inhibitor. SGTC_1664 st014217 9.02 µM 0.976618737538232 0.152829309886887 no 534 0.164378969588659 909 3982782 SGTC_3177 9107506 49.47 µM 0.973007377945259 0.153727025528947 no 535 0.165274817619336 803 8897194 SGTC_1740 st038286 13.222 µM 0.972024039713695 0.153972068257431 no 536 0.165519294611903 814 716786 SGTC_2832 7992762 51.95 µM 0.96941830931509 0.154622651828441 no 537 0.16616826036681 710 2985177 SGTC_1554 st069299 38.7 µM 0.968875182243055 0.154758485086956 no 538 0.166303734682419 819 24207999 SGTC_1147 3809-1045 12.3 µM 0.968097957511204 0.154953002044775 no 539 0.16649772492968 795 325925 SGTC_306 1672-3436 11.6 µM 0.967709806730566 0.155050205431439 no 540 0.166594659515489 853 6797378 SGTC_3150 9097574 49.47 µM 0.967031309731153 0.155220215998896 no 541 0.166764190994081 825 17217476 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.964429333662077 0.155873331877296 no 542 0.167415360758189 843 2333 A French combination drug. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.962558498548399 0.156344043785429 no 543 0.167884566515961 782 77254 SGTC_1039 k821-0043 94 µM 0.962359876915334 0.156394072947155 no 544 0.167934430515794 866 15992768 SGTC_2480 5767542 37.17 µM 0.959512964680684 0.157112316631308 no 545 0.168650195800107 865 2867358 SGTC_834 0312-0008 75.7 µM 0.958235327385439 0.157435354160188 no 546 0.168972053472127 865 6385573 YIL048W NEO1 SGTC_2820 7989630 71.43 µM 0.957899912652898 0.157520232640562 no 547 0.16905661525774 734 2984098 SGTC_399 oxolinic acid 75 µM 0.957609740260999 0.157593686562258 no 548 0.169129792868767 825 4628 A DNA gyrase inhibitor. SGTC_1183 1254-0324 198 µM 0.956285680876181 0.157929143101485 no 549 0.169463961111975 851 5799357 SGTC_1350 1495-0454 146 µM 0.950111209910599 0.159499660443045 no 550 0.171027873916034 894 1069057 SGTC_1244 0416-0015 52.5 µM 0.949296672370307 0.159707604122892 no 551 0.171234872756811 839 96201 SGTC_2324 6149169 200 µM 0.946760666241978 0.16035615772249 no 552 0.171880374552952 819 2888231 SGTC_2147 5545932 89.7195 µM 0.945907424204548 0.160574750696035 no 553 0.172097903222694 846 797404 SGTC_1669 st015249 58.4 µM 0.945094053430023 0.160783310135195 no 554 0.172305430482403 932 722793 SGTC_512 prima-1 270 µM 0.944709844019968 0.16088188818434 no 555 0.172403514983419 899 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3008 9078912 71.4286 µM 0.944494355275768 0.160937194206127 no 556 0.172458542512037 829 16648731 SGTC_2477 5967686 25.23 µM 0.941710084926345 0.161652903917558 no 557 0.173170545179124 842 776118 SGTC_102 gallobenzophenone 83.616 µM 0.940771445297952 0.161894652504836 no 558 0.173410998504365 861 70837 SGTC_2986 9022445 71.43 µM 0.940700924196963 0.16191282486902 no 559 0.173429072625651 874 6459286 SGTC_2819 7996655 46.38 µM 0.940518712209352 0.161959784664407 no 560 0.173475777980733 759 6456960 SGTC_2995 9067767 71.4286 µM 0.939262050342248 0.162283893971094 no 561 0.173798108883816 794 11673567 SGTC_968 1309-0633 340 µM 0.938212341803442 0.162554950779933 no 562 0.174067648538774 879 3761976 SGTC_1841 st054148 70 µM 0.9379030394216 0.162634875310614 no 563 0.174147120536621 808 675442 SGTC_1757 st041620 31.8375 µM 0.937566501084466 0.162721866717649 no 564 0.174233616719831 869 5289815 SGTC_1694 st024011 44.9 µM 0.936468196545031 0.163005976709722 no 565 0.174516089910729 917 2787533 SGTC_203 k066-0004 30.888 µM 0.932555698877414 0.164020682386007 no 566 0.175524707889036 1021 6795412 SGTC_3153 9100258 49.47 µM 0.931647675620583 0.164256762715324 no 567 0.175759317916032 796 25236848 SGTC_1636 st007707 68.9 µM 0.930283743863517 0.164611790236183 no 568 0.176112096170692 895 403051 SGTC_206 4546-0025 72.014 µM 0.929833190421507 0.164729177181151 no 569 0.176228729349722 918 6620745 YIL048W NEO1 SGTC_1123 mangostin 811.285 nM 0.928044422350568 0.165195756731037 no 570 0.176692263577624 833 5281650 An antioxidant. SGTC_113 0099-0221 2.5 µM 0.925423146211716 0.165881029977185 no 571 0.177372921747534 845 89219 SGTC_3202 9113761 49.47 µM 0.924347905991948 0.166162657827941 no 572 0.177652604019948 955 4798415 SGTC_2143 5623677 140.463 µM 0.924343155242077 0.166163902833432 no 573 0.177653840361441 865 5375313 SGTC_1969 st069479 40.1 µM 0.922008470070047 0.166776471322839 no 574 0.178262078799988 853 3895485 SGTC_258 haloperidol 50.781 µM 0.920375595241915 0.167205765428344 no 575 0.178688258678856 851 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1794 st048918 76.9 µM 0.914935055760013 0.168641256460522 no 576 0.180112862634535 820 672303 SGTC_1615 st002656 86.5 µM 0.914817599892092 0.168672334393355 no 577 0.180143696844599 874 1584458 SGTC_2075 5212009 200 µM 0.913595820164562 0.168995826324491 no 578 0.180464631767451 820 780898 SGTC_1066 ketoconazole 628 nM 0.91230918568208 0.169336920412664 no 579 0.180802990096444 950 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_910 3454-3003 490 µM 0.910430654618556 0.169835722629188 no 580 0.181297718670744 917 820824 SGTC_1313 1220-0047 237 µM 0.910237838364053 0.169886973965103 no 581 0.181348546546152 938 3528706 SGTC_2268 7933382 153.85 µM 0.909180019999103 0.17016832274385 no 582 0.181627554477943 1013 935025 YOR257W CDC31 SGTC_1698 5-fluorocytosine 1.055 µM 0.908966645494929 0.170225110293536 no 583 0.181683866224843 923 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1829 berberine 14.4 µM 0.907769652078347 0.170543903530561 no 584 0.181999967709214 894 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1192 1488-0095 21.4 µM 0.907289833328275 0.170671800109558 no 585 0.182126774522961 875 915875 SGTC_1260 0700-1617 7.75 µM 0.905962520456639 0.171025917561091 no 586 0.182477845255935 900 2853078 SGTC_220 paclitaxel 373.376 µM 0.903570446497288 0.171665291361903 no 587 0.183111609013456 833 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_472 calcifediol 10 µM 0.900488684115683 0.172491258692424 no 588 0.183930122307676 836 5283731 A vitamin D metabolite. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.899564706867483 0.172739394144725 no 589 0.184175973116047 894 5377381 SGTC_1871 st057448 67.3 µM 0.898916972875021 0.172913479657509 no 590 0.184348443326066 940 691747 SGTC_836 0330-0104 1.35 µM 0.89646922985237 0.173572346059162 no 591 0.185001103528429 901 46494820 SGTC_2397 5161689 200 µM 0.895980333299785 0.173704134986394 no 592 0.185131633511208 925 2259942 SGTC_3155 9099265 49.47 µM 0.894652267410425 0.174062455017736 no 593 0.18548650110961 843 25236499 SGTC_3351 9150312 21.596 µM 0.893700781575598 0.174319460226487 no 594 0.185741003551343 897 4904905 SGTC_250 brefeldin a 552.239 µM 0.890342847242459 0.175228395305655 no 595 0.186640910343975 822 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1160 4092-0570 10.5 µM 0.890199190501431 0.175267347640287 no 596 0.18667946962925 911 4994975 SGTC_595 3909-8003 73.7 µM 0.890146694033249 0.175281583357727 no 597 0.18669356157524 926 699517 SGTC_2112 5488546 200 µM 0.889881917163724 0.175353395337713 no 598 0.186764647276108 909 600757 SGTC_3208 9114115 49.47 µM 0.888574126786734 0.175708363824549 no 599 0.187116000646851 821 650895 SGTC_631 k072-0230 41.5 µM 0.888485464137139 0.175732445651748 no 600 0.187139835706275 956 5773147 SGTC_3149 9097855 49.47 µM 0.888152423899374 0.175822922007507 no 601 0.187229383233025 899 25236625 YMR079W SEC14 SGTC_64 000l-0018 272.079 µM 0.888009466447699 0.175861768013254 no 602 0.187267829616332 957 6811119 SGTC_1429 4049-0205 9.46 µM 0.882649492807948 0.177322161550427 no 603 0.188712839442079 966 22774478 SGTC_2696 st077691 74.316 µM 0.882170417602327 0.177453063505436 no 604 0.188842328371542 844 757133 SGTC_1579 chlormadinone acetate 49.4 µM 0.882169079919913 0.177453429097613 no 605 0.188842690009497 956 45114258 A steroidal progestin. SGTC_478 N-arachidonylglycine 10 µM 0.880779936772086 0.177833342235318 no 606 0.189218470507144 836 5283389 SGTC_49 0717-0965 32.132 µM 0.879676700186547 0.178135428770204 no 607 0.18951723750496 1006 5889349 YGL099W LSG1 SGTC_1631 benzylvanillin 81.9 µM 0.87759202174491 0.178707134719376 no 608 0.190082580237262 919 75506 SGTC_1365 1672-3266 55.4 µM 0.877551320518211 0.178718308182031 no 609 0.190093628284367 957 6415873 SGTC_2610 ononetin 44.17 µM 0.877490403986439 0.178735032052415 no 610 0.190110164363874 920 259632 SGTC_2795 7780010 54.55 µM 0.876990591893096 0.178872286402941 no 611 0.190245874089355 886 953673 SGTC_2019 4016004 108 µM 0.876118916665432 0.179111817483326 no 612 0.190482695010854 869 45595336 SGTC_2770 toltrazuril 17.5 µM 0.875655317130043 0.17923929399161 no 613 0.190608721668503 974 68591 Kills coccidiodes. SGTC_1037 k284-1091 78.7 µM 0.873751370713525 0.179763422529553 no 614 0.191126834237727 889 3334711 SGTC_463 ikarugamyin 104 µM 0.873317578519073 0.179882973706235 no 615 0.191245000877601 963 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3142 9086498 49.47 µM 0.873267452943053 0.179896791307196 no 616 0.191258658160636 892 25236367 SGTC_2963 9082507 9 µM 0.872318736508879 0.180158439884978 no 617 0.191517259465924 875 16459611 SGTC_95 0471-0001 561.058 µM 0.871567327418093 0.180365842072114 no 618 0.191722230642502 925 4015405 SGTC_2711 st079103 59.1 µM 0.871505679715201 0.18038286457454 no 619 0.191739053011633 940 54693780 SGTC_2241 6772625 37.8075 µM 0.87124896623736 0.180453760548019 no 620 0.191809114470271 941 2285411 SGTC_977 1348-1378 135 µM 0.870509026039845 0.180658205923826 no 621 0.192011144372461 1005 X977 SGTC_1899 st063254 59.6 µM 0.870030201344207 0.180790582494915 no 622 0.192141949863003 852 3093813 SGTC_518 1021-0119 62.6 µM 0.869718427906194 0.180876808509782 no 623 0.192227149533635 870 1097762 SGTC_237 nikkomycin 200 µM 0.86662536535421 0.181733641068956 no 624 0.193073655410233 963 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_116 0155-0182 31.788 µM 0.864520647140836 0.182318134334899 no 625 0.193650971526158 997 771486 SGTC_231 b-estradiol 524 µM 0.864366239344722 0.182361060534148 no 626 0.193693366396082 880 450 A steroid. SGTC_2873 9040596 71.43 µM 0.863462667417836 0.182612384979817 no 627 0.193941568433824 950 6463863 SGTC_1162 k048-0130 20.1 µM 0.862707562698917 0.182822579766002 no 628 0.19414913663022 928 6797406 SGTC_31 0508-1974 57.237 µM 0.861656254912926 0.183115478528533 no 629 0.194438352340387 934 6810525 SGTC_1924 st058459 75.1 µM 0.860188397040497 0.183524919259516 no 630 0.194842599796353 946 688683 SGTC_208 k072-0098 12.366 µM 0.859496233542833 0.183718187489557 no 631 0.195033398555204 1039 5948901 SGTC_79 0052-0007 94.094 µM 0.858236870173611 0.184070156278999 no 632 0.195380840359818 966 2801472 SGTC_1968 st069590 43.6 µM 0.857217508593632 0.184355356195672 no 633 0.195662343977231 943 6384066 SGTC_2491 paeonol 100 µM 0.857123730259636 0.18438160757062 no 634 0.195688253862844 944 11092 Increases levels of cortical cytochrome oxidase. SGTC_1998 st075797 76.8 µM 0.854483007773353 0.185121779717777 no 635 0.19641871024043 1026 24208315 SGTC_2616 abietic acid 100 µM 0.853636421267853 0.185359460897575 no 636 0.196653235863573 1013 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_796 1234-0020 70.7 µM 0.85332074875947 0.185448135178273 no 637 0.196740728438207 967 46495034 SGTC_2607 solasodine 47.35 µM 0.851040680332713 0.186089401624441 no 638 0.1973733776847 973 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_954 1189-0853 2.85 µM 0.849194008665406 0.186609781936505 no 639 0.197886673273991 1028 2828194 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.847750851589414 0.187017080974539 no 640 0.198288369889844 939 17037758 SGTC_1706 st031321 9.9705 µM 0.846477268560372 0.187376977953973 no 641 0.198643274774183 1011 6103185 SGTC_2871 9038510 12.99 µM 0.845974539779195 0.18751915994187 no 642 0.198783473816762 1026 4945164 SGTC_1895 st058434 18.3 µM 0.84391605505203 0.18810203666407 no 643 0.19935815795224 1026 5393175 SGTC_1854 st056233 32.9 µM 0.843100440614541 0.188333293512933 no 644 0.199586136176541 949 5393174 SGTC_1902 st060212 70.5 µM 0.839633221564421 0.1893183345008 no 645 0.200557033163867 1043 688944 SGTC_927 2425-1185 123 µM 0.838957653651227 0.189510632663948 no 646 0.200746536520107 974 730375 SGTC_619 1652-1634 108 µM 0.836755485210957 0.1901383065952 no 647 0.201365011909155 920 5400454 SGTC_857 0438-0306 1.35 µM 0.835957570013842 0.190366047615677 no 648 0.201589386662671 997 4686136 SGTC_3007 9078383 71.4286 µM 0.835583044482434 0.1904730024738 no 649 0.201694755342548 992 6496995 SGTC_1424 4048-1941 275 µM 0.834952537959351 0.190653142244665 no 650 0.201872215979648 1075 X1424 SGTC_803 4488-1585 147 µM 0.834792266327166 0.190698949545137 no 651 0.201917340490622 971 747204 SGTC_2014 4013930 200 µM 0.834789870462551 0.190699634359417 no 652 0.201918015092601 1031 64556 SGTC_2936 9038235 15.59 µM 0.832069419482209 0.191478199335532 no 653 0.20268488090376 1023 4749415 SGTC_2295 7971645 200 µM 0.830713765651072 0.191866899466624 no 654 0.203067673991455 960 2978226 YKL099C UTP11 SGTC_1197 1601-0112 267 µM 0.83041667590863 0.1919521470704 no 655 0.203151620217602 993 7350313 SGTC_1778 st046819 58.9 µM 0.829204830000619 0.192300116963149 no 656 0.203494256171566 1098 671715 SGTC_333 3486-0131 40.1 µM 0.828457206502605 0.19251498215221 no 657 0.203705810224963 1044 6744690 SGTC_1310 1188-0297 994 nM 0.826960679706923 0.192945521032967 no 658 0.204129674213858 991 1588352 SGTC_1764 st044502 93.5 µM 0.826720990677893 0.193014532257844 no 659 0.204197610544568 995 8407 SGTC_2570 licareol 100 µM 0.826451664399783 0.193092094615455 no 660 0.204273963180987 934 443158 SGTC_2601 securinine 100 µM 0.826278015279426 0.193142113322728 no 661 0.204323200839897 958 442872 A GABA receptor antagonist. SGTC_1684 st024538 14.6195 µM 0.825562668258335 0.193348248629537 no 662 0.204526109722414 993 6732859 SGTC_784 4579-0127 173 µM 0.824677697277867 0.193603448678537 no 663 0.204777298473382 1054 1948547 SGTC_3139 9095020 49.47 µM 0.823711526197231 0.193882298925637 no 664 0.205051744329481 840 25236292 SGTC_780 0109-0199 192 µM 0.823324977123983 0.19399393082283 no 665 0.205161606780456 1055 610414 SGTC_818 4072-2707 53.5 µM 0.82278157994641 0.194150925252216 no 666 0.205316106706265 1013 882871 SGTC_3116 9124943 49.47 µM 0.822640639613252 0.194191657361946 no 667 0.205356190468206 956 41905195 YPL160W CDC60 SGTC_271 rotenone 740 µM 0.819196320213111 0.195188691400144 no 668 0.206337207020755 1072 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_179 1273-0063 6.77 µM 0.818616456969007 0.195356851013631 no 669 0.206502637313671 1000 3108139 SGTC_106 0092-0003 11.579 µM 0.817360260190843 0.195721448234783 no 670 0.206861289462116 980 1072148 SGTC_85 0868-0259 160.055 µM 0.816935868428408 0.195844716532002 no 671 0.206982539274376 953 83173 SGTC_2748 diazoxide 86.69 µM 0.81503158033986 0.196398413405922 no 672 0.207527116743515 939 3019 A potassium channel activatior. SGTC_2346 9031566 143.75 µM 0.812894238937165 0.197021002403857 no 673 0.208139348926126 1017 4771086 SGTC_3100 9120536 49.47 µM 0.81158319157555 0.197403489541541 no 674 0.208515419637015 924 16421196 SGTC_957 1187-1561 14.1 µM 0.811313093051037 0.197482344283637 no 675 0.208592946478641 1044 1538454 SGTC_2328 6201408 200 µM 0.810906461043918 0.197601095626147 no 676 0.208709694803257 957 2890418 SGTC_2141 5621638 7.665 µM 0.809215876370703 0.198095270472405 no 677 0.209195492165045 1031 2856238 SGTC_2111 5486399 200 µM 0.808060521847255 0.198433421033816 no 678 0.209527871237335 1056 689674 SGTC_1880 MG-132 525 µM 0.806672644827468 0.198840086702172 no 679 0.209927554173656 981 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_584 0986-0246 15.4 µM 0.806634410305993 0.198851297010735 no 680 0.209938571347579 1147 53315 YDR232W HEM1 SGTC_958 1222-0007 33 µM 0.806240268630419 0.198966881006934 no 681 0.2100521620094 1067 7312461 SGTC_2425 5628681 7.85 µM 0.803684081124562 0.199717477926941 no 682 0.210789724996914 1073 5714958 SGTC_2193 5925765 200 µM 0.801955350876914 0.200226065216343 no 683 0.211289393123614 1030 877370 SGTC_3240 9133527 49.47 µM 0.797886747148628 0.201426103675056 no 684 0.21246810740497 1003 17617455 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.797369063117922 0.20157910357839 no 685 0.212618360534501 1080 688761 SGTC_809 3998-0021 90 µM 0.79682316386854 0.201740517799281 no 686 0.212776870075799 1020 715485 SGTC_2907 7721985 69.9 µM 0.796304896966747 0.201893833155373 no 687 0.212927419992167 1052 3267881 SGTC_1403 3909-7815 62.9 µM 0.795015244372304 0.202275644897206 no 688 0.213302317292165 1014 6615483 SGTC_2603 homopterocarpin 100 µM 0.792972918217043 0.202881174351036 no 689 0.213896800703039 1039 101795 A weak amylase inhibitor. SGTC_2166 5933061 31.504 µM 0.791438733090585 0.203336756416346 no 690 0.214344007469295 1225 2877375 SGTC_3040 9091894 49.47 µM 0.789888237788341 0.203797801517423 no 691 0.214796520592531 980 25236966 SGTC_2005 4024620 188 µM 0.789239619181818 0.2039908552014 no 692 0.214985984916405 1047 236743 SGTC_770 0389-1121 67.2 µM 0.787297814291947 0.20456946157139 no 693 0.215553774442594 1105 6753108 SGTC_572 0960-0087 17.7 µM 0.787117936176316 0.204623109857008 no 694 0.215606415313582 1108 6796365 SGTC_2131 toluylene red 5.2905 µM 0.785490237965959 0.205108948032746 no 695 0.216083095844921 1024 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1558 st069300 45.6 µM 0.781846303765854 0.206199077996264 no 696 0.217152452484391 1005 24208000 SGTC_1715 st032160 10.2275 µM 0.780488035432906 0.206606298639777 no 697 0.217551833643236 1016 5289825 SGTC_11 0438-0307 1.3 µM 0.779442035693634 0.206920222835242 no 698 0.217859685017665 1054 4011476 SGTC_2138 5575593 77.673 µM 0.777465413828107 0.207514214407059 no 699 0.218442116085483 1090 762213 SGTC_1337 1486-1011 40.3 µM 0.777138015131501 0.20761269767486 no 700 0.21853867382547 1107 X1337 SGTC_1357 1503-1303 39.5 µM 0.776882069806383 0.207689706619018 no 701 0.218614175362237 1113 292895 SGTC_2756 carbadox 75.1 µM 0.774349112729155 0.20845273332593 no 702 0.219362183825181 1031 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1191 1487-1166 10.6 µM 0.773809273797895 0.208615567585303 no 703 0.219521793768222 1146 3955771 SGTC_1397 3532-0190 20.1 µM 0.773593412783521 0.208680699780347 no 704 0.219585634366863 1013 5322280 SGTC_1970 st070122 35.8 µM 0.772947012417331 0.208875811185228 no 705 0.219776870147946 1091 102928 SGTC_2977 9011197 71.43 µM 0.772244466141856 0.209087991673504 no 706 0.219984824925806 1006 2704722 SGTC_1105 epirubicin 18.1 µM 0.77153812241942 0.209301446951231 no 707 0.220194017524253 1064 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2496 diffractaic acid 79.83 µM 0.771268780645222 0.20938287511658 no 708 0.220273816520998 1074 94870 An apoptosis inducer which activates caspases. SGTC_1053 3366-3204 134 µM 0.771214071885766 0.209399417100682 no 709 0.220290027336302 1086 3632071 YPR165W RHO1 SGTC_775 4577-0580 57.3 µM 0.771120880427291 0.209427596655574 no 710 0.220317642579188 1089 2006902 SGTC_2236 dapsone 200 µM 0.770646101585194 0.209571196558046 no 711 0.220458363674589 1127 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1015 4130-4525 82 µM 0.770515095842548 0.209610830276933 no 712 0.220497201917225 1093 1363237 SGTC_1513 0337-0559 19 µM 0.76980264167355 0.209826449200716 no 713 0.22070848623467 1014 775073 SGTC_2772 vinpocetine 57.06 µM 0.767679891692311 0.210469656074451 no 714 0.221338692713894 1064 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_110 0850-0284 111.64 µM 0.766882121239374 0.210711684524988 no 715 0.221575802267909 959 3906265 SGTC_2451 5856223 45.7 µM 0.766690110264535 0.21076996138716 no 716 0.221632892527871 1064 2179896 SGTC_1981 st071826 47 µM 0.765350071769627 0.211176936897374 no 717 0.222031557607924 1042 11838600 SGTC_870 0573-2213 57.6 µM 0.764749223693883 0.211359566490489 no 718 0.222210444388613 1101 3916321 SGTC_2888 9058547 12.99 µM 0.764688609910478 0.211377995369244 no 719 0.222228495121227 988 16476514 SGTC_492 tmb-8 126 µM 0.764284640186582 0.211500841453826 no 720 0.22234881832637 973 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3183 9108214 49.47 µM 0.762837535853972 0.211941244867498 no 721 0.222780146183178 1009 4974831 SGTC_3029 9088683 49.47 µM 0.758654018168839 0.21321744559267 no 722 0.224029774968002 1139 25236615 SGTC_2348 9022543 33.42 µM 0.758587390835701 0.213237806745609 no 723 0.224049708905496 1080 3162678 YDL140C RPO21 SGTC_599 1935-0052 86.5 µM 0.758177101526011 0.213363215159919 no 724 0.224172483755769 1125 9557311 SGTC_946 3434-1334 87.4 µM 0.755678362243238 0.214127903825143 no 725 0.224921030128993 1065 4047976 SGTC_2126 5251174 33.877 µM 0.755281737843027 0.214249429201696 no 726 0.225039976906907 1158 790722 SGTC_2685 mycophenolic acid 18.85 µM 0.754665721878096 0.214438255496014 no 727 0.225224789384043 1080 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1217 1183-1422 255 µM 0.753232332173554 0.214878004300705 no 728 0.225655156758513 1153 2849664 SGTC_1893 st059353 36.1 µM 0.752457679112357 0.215115877549877 no 729 0.225887935622396 1082 3112488 SGTC_2923 7992654 58.14 µM 0.751983116392121 0.215261677332946 no 730 0.226030606081687 1102 2985126 SGTC_1868 st057644 42.7 µM 0.751361955105567 0.215452603188217 no 731 0.226217426238947 1139 688665 SGTC_373 0844-0104 25.9 µM 0.749088101068943 0.216152353325511 no 732 0.226902053167838 1157 5375804 SGTC_50 0929-0078 56.389 µM 0.748832810496852 0.2162309978981 no 733 0.226978990635087 1020 1377751 SGTC_1379 2144-0755 36.5 µM 0.748518845854949 0.216327740262057 no 734 0.227073631001499 1165 5392327 SGTC_923 1900-2434 73.3 µM 0.747995391467615 0.216489088690045 no 735 0.227231468655784 1103 5910570 SGTC_2523 spermine 47.74 µM 0.74508435731183 0.217387648943642 no 736 0.22811036247707 1100 1103 A DNA binding polyamine. SGTC_1392 3455-1037 33.9 µM 0.744721556752843 0.217499786721763 no 737 0.228220032329989 1113 981132 SGTC_654 1124-0271 80.9 µM 0.744639385492815 0.21752518961762 no 738 0.228244875741098 1112 5403748 SGTC_2661 dactinomycin 12.96 µM 0.744614399418617 0.217532914295802 no 739 0.22825243025687 1133 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2886 9058944 51.95 µM 0.744060199561473 0.217704291055857 no 740 0.228420028185345 996 4949929 SGTC_973 1325-0077 65.9 µM 0.743351146801817 0.217923666953038 no 741 0.228634556628398 1165 2835149 SGTC_1526 st051518 75 µM 0.742142092448638 0.218298033648658 no 742 0.229000624579803 1024 673993 SGTC_3166 9102297 49.47 µM 0.740184104950731 0.218905082156575 no 743 0.229594145500605 1093 25237072 SGTC_3114 9122766 49.47 µM 0.73985764954696 0.21900638977193 no 744 0.229693187041391 1049 17176985 SGTC_2778 tioconazole 65.09 nM 0.738831028130187 0.219325152814961 no 745 0.230004804061124 1103 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3248 9135562 49.47 µM 0.738370639499864 0.219468188732759 no 746 0.230144625594562 1159 17650701 SGTC_320 4092-0846 5.34 µM 0.737270229874773 0.219810286716563 no 747 0.230479016178522 1131 1359356 SGTC_1548 st061468 90.8 µM 0.736289308942857 0.220115495642668 no 748 0.230777325545135 1157 390799 SGTC_2365 9042475 200 µM 0.736150121266385 0.220158822916543 no 749 0.230819671586602 1161 6464479 SGTC_559 1550-0661 158 µM 0.735490047916435 0.220364361565818 no 750 0.231020549399093 1139 5830875 SGTC_564 3555-0129 330 µM 0.734354732513227 0.220718141870754 no 751 0.231366284114284 1047 563260 SGTC_3002 9075603 71.4286 µM 0.734269347888783 0.220744762071063 no 752 0.231392297738873 1155 20105405 SGTC_3190 9110366 49.47 µM 0.733137903338035 0.22109768393761 no 753 0.231737162173203 1063 17123768 SGTC_2825 7998094 58.44 µM 0.732159975067473 0.221402980734927 no 754 0.232035465408917 1090 2987815 SGTC_191 3914-0123 66.505 µM 0.73145022278413 0.221624707264157 no 755 0.232252099154258 1066 3144412 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.729372688761236 0.222274457490437 no 756 0.232886859702871 1128 688667 SGTC_3027 9089541 49.47 µM 0.727654214320067 0.222812731939041 no 757 0.233412642244309 1148 9943819 SGTC_1173 0443-0020 122 µM 0.727095677417495 0.222987841185056 no 758 0.233583673273192 1147 5331295 SGTC_621 3584-0052 32.1 µM 0.723938464929001 0.22397914465245 no 759 0.234551756975813 1176 2273927 SGTC_2549 cedrol 20.94 µM 0.723458607019666 0.224130029617338 no 760 0.234699087969687 1095 6708665 A sedative which affects the nervous system. SGTC_324 1315-0088 19.6 µM 0.723363391296443 0.22415997580303 no 761 0.234728328179717 1096 6787421 SGTC_1180 1193-0155 285 µM 0.722074738834494 0.224565491799219 no 762 0.235124264091203 1149 2921347 SGTC_2746 daunorubicin 9.88 µM 0.721698726796379 0.224683894486869 no 763 0.235239862523605 1056 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1621 st003705 32.4 µM 0.721610622961465 0.22471164268293 no 764 0.235266953069115 1195 24207032 SGTC_1205 4161-2785 76 µM 0.721581425195256 0.224720838912766 no 765 0.235275931303642 1088 3498106 SGTC_2307 7538926 6.34 µM 0.721204048519564 0.224839717986138 no 766 0.235391990636671 1164 96582 SGTC_639 0833-0042 114 µM 0.718812682539148 0.225593860921464 no 767 0.23612817114932 1155 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2821 7996764 71.43 µM 0.718785141123157 0.225602554732263 no 768 0.236136657138204 1237 2987135 SGTC_1084 voriconazole 435 nM 0.717862291081993 0.225893974093053 no 769 0.236421100376971 1176 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2861 9024595 19.48 µM 0.717469253682836 0.226018152803162 no 770 0.236542300629092 1109 16482810 SGTC_2148 5546263 113.568 µM 0.717456980631598 0.226022031049433 no 771 0.23654608579874 1132 792097 SGTC_3205 9113483 49.47 µM 0.716735492711509 0.226250085099254 no 772 0.236768660678945 1157 17018033 SGTC_1280 0880-0253 10.1 µM 0.716709756451472 0.226258222436251 no 773 0.236776602294305 1141 6836607 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.712288567147069 0.227658573725009 no 774 0.238143051118369 1175 5355888 SGTC_1449 4112-4002 201 µM 0.711705867256478 0.227843499173726 no 775 0.238323466835489 1150 2059539 SGTC_913 3487-1245 167 µM 0.711376638690117 0.227948020404281 no 776 0.238425435772455 1139 4016153 SGTC_262 fenpropimorph 62.5 µM 0.711122541729603 0.228028707806472 no 777 0.238504151218747 1124 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2976 9009005 19.48 µM 0.711086995254516 0.228039996718159 no 778 0.23851516412046 1188 2993148 SGTC_51 1013-0126 23.419 µM 0.710772775222128 0.22813980093422 no 779 0.238612526928929 1218 1627850 SGTC_3119 9125183 49.47 µM 0.710447566994847 0.228243121137662 no 780 0.238713317391465 1034 22695334 SGTC_808 0711-0032 135 µM 0.710193727047939 0.228323785573292 no 781 0.238792005157507 1159 4252555 SGTC_1198 1612-1005 86.7 µM 0.710128003536284 0.228344673588776 no 782 0.23881238108063 1218 6998509 SGTC_2928 9011484 9.79 µM 0.707960509885632 0.229034140231586 no 783 0.239484890602156 1159 2994751 SGTC_330 1488-0319 80.1 µM 0.706227591778214 0.229586210129377 no 784 0.240023307110469 1148 6846614 SGTC_1427 4048-4900 550 nM 0.706211773841221 0.229591252810147 no 785 0.240028224770901 1170 24132586 SGTC_2351 9026858 72.31 µM 0.705874518222101 0.229698783012087 no 786 0.240133087710354 1139 1409300 SGTC_304 1310-0298 97 µM 0.703473547092987 0.230465120602535 no 787 0.240880343217743 1142 1550234 SGTC_2739 tacrine 100.86 µM 0.702177373710394 0.230879424156111 no 788 0.241284277124849 1198 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_426 0988-0037 14.6 µM 0.700675933806462 0.231359857713142 no 789 0.241752639174115 1204 5383008 SGTC_1782 st039423 80.636 µM 0.700564843459851 0.231395426749672 no 790 0.241787312504191 1162 2068169 SGTC_395 anisomycin 6.25 µM 0.699742728932775 0.231658747101961 no 791 0.242043993358959 1155 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2190 6049624 200 µM 0.694203185397161 0.233437389884402 no 792 0.243777397628576 1133 2265554 SGTC_2250 alverine citrate 130 µM 0.693968998277963 0.233512749476565 no 793 0.243850825542695 1148 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_176 1486-1328 72.834 µM 0.69243817093857 0.234005690027853 no 794 0.244331100815318 1202 22310231 SGTC_554 4483-2211 187 µM 0.69202230632082 0.234139701772048 no 795 0.244461660422253 1182 747107 SGTC_76 0433-0009 400.328 µM 0.690357290155925 0.234676676168508 no 796 0.244984764187807 1158 2841569 SGTC_675 1309-0189 238 µM 0.689126214291744 0.235074140552426 no 797 0.245371922367929 1178 4246530 SGTC_3288 9119690 36.221 µM 0.688579037310075 0.235250921068643 no 798 0.245544108282196 1186 17595618 YKL019W RAM2 SGTC_577 r071-0003 38.6 µM 0.687601635063503 0.235566880226221 no 799 0.245851839143433 1248 4568517 YMR134W ERG29 SGTC_609 0986-0026 86.3 µM 0.687009768819144 0.235758323142674 no 800 0.246038286245888 1195 2848610 SGTC_1786 berberine 21.6 µM 0.686585480704747 0.235895614618954 no 801 0.246171990287646 1197 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2476 5806916 10.51 µM 0.683959922121743 0.236746174262254 no 802 0.24700023687653 1144 2870194 SGTC_75 0159-0059 199.013 µM 0.683253428921868 0.236975333069193 no 803 0.247223358270137 1270 5377270 SGTC_1859 st055998 20 µM 0.682487510963292 0.237223904620352 no 804 0.247465368615508 1233 676301 SGTC_2221 6807166 181.081 µM 0.682373966173751 0.237260766711836 no 805 0.247501256615969 1174 674925 SGTC_2363 9053361 176 µM 0.681377642472658 0.237584356112689 no 806 0.247816282984292 1252 6469797 YMR079W SEC14 SGTC_2879 9041815 71.43 µM 0.681039191188261 0.237694334556868 no 807 0.247923346169543 1169 4942971 SGTC_2008 4012253 172 µM 0.68041745074834 0.237896439482926 no 808 0.248120087267566 1240 603940 SGTC_3277 9138724 49.47 µM 0.679756437890783 0.238111413727339 no 809 0.248329346875094 1142 15943418 SGTC_1433 4060-0023 7.6 µM 0.679282815851679 0.23826551027298 no 810 0.248479341223767 1227 3840627 SGTC_2463 5473429 200 µM 0.679253661356691 0.238274997695005 no 811 0.248488575921658 1179 5399405 SGTC_2625 euphol 100 µM 0.679085948242892 0.238329578721425 no 812 0.24854170266901 1213 6708538 A triterpene alcohol. SGTC_3282 9108498 15.4605 µM 0.678382403731488 0.238558616818101 no 813 0.248764631496384 1195 16459645 SGTC_1423 4048-0112 5.59 µM 0.678187974728391 0.23862193419556 no 814 0.248826258068359 1226 X1423 SGTC_1456 k015-0012 13 µM 0.677081560968455 0.238982421809496 no 815 0.249177103660013 1289 2989616 SGTC_995 3931-2021 34.6 µM 0.676707645560687 0.239104316819764 no 816 0.24929573229523 1206 730143 SGTC_1734 st037168 69.4 µM 0.676104988161805 0.239300852358996 no 817 0.249486994938676 1216 708907 SGTC_3211 9128781 49.47 µM 0.675892656072128 0.239370118029034 no 818 0.249554400381709 1204 17194361 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.675046612366907 0.239646217923234 no 819 0.249823075485354 1179 279621 SGTC_1840 st055363 71 µM 0.674962643813844 0.239673629896861 no 820 0.249849749455877 1178 676033 SGTC_2914 7968218 45.32 µM 0.674490759476595 0.239827710833889 no 821 0.249999679274407 1177 2977111 SGTC_1735 st034310 56.75 µM 0.67338497317824 0.240188986721982 no 822 0.250351203017986 1267 871153 SGTC_734 2023-0417 80 µM 0.672109982996749 0.240605911779589 no 823 0.250756840801214 1213 3935732 SGTC_46 0329-0187a 2.197 µM 0.670488290558912 0.241136778119073 no 824 0.251273284221802 1250 46494817 SGTC_2252 omeprazole 400 µM 0.668048147253605 0.241936765457901 no 825 0.25205142962762 1190 4594 A proton pump inhibitor. SGTC_204 PMA1.184 62.41 µM 0.667131219629198 0.24223774677587 no 826 0.252344160012514 1263 2252213 YGL008C PMA1 SGTC_1078 idebenone 36.1 µM 0.66621490741426 0.24253872872019 no 827 0.252636872868019 1253 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_291 SEC14.278 35.5 µM 0.665871066359621 0.242651722756565 no 828 0.25274675786468 1234 1068044 SGTC_2644 guaiazulene 100 µM 0.665705264407043 0.242706219254791 no 829 0.252799753976285 1252 3515 A coloring agent. SGTC_2181 6316240 54.2555 µM 0.665686915701312 0.242712250593398 no 830 0.252805619224862 1225 12779990 SGTC_2108 5365811 200 µM 0.665145049390113 0.242890402137673 no 831 0.252978861588119 1267 780283 SGTC_411 enrofloxacin 100 µM 0.663119322070554 0.2435570347901 no 832 0.253627068320143 1305 71188 A bacterial gyrase inhibitor. SGTC_671 0560-0003 407 µM 0.662881474827687 0.243635371074286 no 833 0.253703233570926 1196 3238678 SGTC_549 1661-1316 519 µM 0.662101414919811 0.243892383505138 no 834 0.253953114549054 1278 2857282 SGTC_3251 9135047 49.47 µM 0.662008350669148 0.243923055876125 no 835 0.253982934964906 1252 17682963 SGTC_21 0849-0113 22.993 µM 0.660905193509556 0.244286795948003 no 836 0.25433655762068 1219 1560156 SGTC_2028 5153890 36.43 µM 0.659545629683772 0.244735481985062 no 837 0.254772727516712 1233 2830968 YPR165W RHO1 SGTC_3333 9141820 12.094 µM 0.658503375831304 0.245079748945955 no 838 0.255107364263857 1246 1939433 SGTC_178 4092-0806 87.505 µM 0.658123242964654 0.245205375461906 no 839 0.255229470822792 1249 2169044 SGTC_502 l-744,832 89.3 µM 0.65778207071602 0.245318155728567 no 840 0.255339088438891 1225 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3339 9145883 14.936 µM 0.656913386092634 0.245605439982224 no 841 0.255618305247355 1186 2030670 SGTC_884 0851-0618 334 µM 0.655622196577267 0.2460327852702 no 842 0.256033620093372 1242 9642473 SGTC_971 1315-0384 26.7 µM 0.655010415187804 0.24623540588967 no 843 0.25623052417984 1247 6769120 SGTC_1930 st074634 34.3 µM 0.654891101615017 0.246274932700091 no 844 0.25626893488924 1238 684253 YOR116C RPO31 SGTC_781 4335-2806 94.4 µM 0.654148900375841 0.246520889298983 no 845 0.256507939694173 1353 845254 SGTC_1404 3909-7820 48.3 µM 0.653875887776121 0.246611395500772 no 846 0.256595884842542 1246 23741373 SGTC_2860 9025725 38.96 µM 0.652631751464258 0.247024063451802 no 847 0.256996855397728 1223 40546248 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.652258595561204 0.247147907630907 no 848 0.257117182683808 1283 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2431 5490079 200 µM 0.651121004274952 0.247525659917258 no 849 0.257484189359348 1287 5722345 SGTC_930 2810-3379 265 µM 0.649431853655643 0.248087133400461 no 850 0.258029640247644 1352 1015764 SGTC_670 4204-0025 119 µM 0.648950810299247 0.248247156365128 no 851 0.258185085589816 1284 719039 SGTC_2084 5306078 60.6385 µM 0.647291423891028 0.248799586808641 no 852 0.258721675475253 1227 679340 SGTC_635 k038-0028 24.7 µM 0.646820183629987 0.248956587814782 no 853 0.258874163936183 1301 4035102 SGTC_1963 st076565 50.3 µM 0.646808173664724 0.248960589809959 no 854 0.258878050843937 1282 4914280 SGTC_1178 0988-0033 191 µM 0.645012327171943 0.24955939204879 no 855 0.259459598624386 1277 5392207 SGTC_1976 st070609 63.5 µM 0.644474317918284 0.249738933252628 no 856 0.259633953065271 1228 682556 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.643716050285164 0.249992094167546 no 857 0.259879790025032 1294 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2725 haloperidol 53.21 µM 0.643670625037428 0.250007264503387 no 858 0.259894521096646 1232 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3233 9132340 49.47 µM 0.641958887181946 0.25057927684451 no 859 0.260449938779823 1239 17682950 SGTC_2659 sanguinarine 24.21 µM 0.640849997212062 0.250950204921871 no 860 0.260810072848178 1240 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_666 0272-0154 136 µM 0.640383255341217 0.251106418773625 no 861 0.260961733124654 1298 6870312 SGTC_3105 9121040 49.47 µM 0.639091601452402 0.251538990465022 no 862 0.261381671593428 1153 41448907 SGTC_2062 5245942 200 µM 0.638993848434559 0.251571743727098 no 863 0.261413466869764 1338 1376160 SGTC_2426 5582046 32.21 µM 0.636589135169996 0.252378179240462 no 864 0.262196252032362 1305 2251934 SGTC_645 0845-0943 5.41 µM 0.636561283610924 0.252387527409419 no 865 0.262205325335803 1259 1885106 SGTC_988 1497-1057 103 µM 0.63540649911189 0.25277528285552 no 866 0.26258166522786 1296 3533044 SGTC_2798 7813637 45.45 µM 0.635053038674417 0.252894031049953 no 867 0.262696911875819 1285 956368 SGTC_3340 9146634 11.102 µM 0.634013871054535 0.253243318687955 no 868 0.263035884853863 1295 4907387 SGTC_2738 aclarubicin 5.55 µM 0.633143680690235 0.253536004294925 no 869 0.263319909896492 1231 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2580 diallyl disulphide 81.36 µM 0.631727989198547 0.254012546859941 no 870 0.263782317726879 1310 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_758 0868-0029 16 µM 0.631438409027747 0.254110081665289 no 871 0.263876954392155 1302 762687 SGTC_2302 7771753 200 µM 0.630438027633663 0.254447175730832 no 872 0.264204018606046 1266 2203047 SGTC_753 1322-0200 289 µM 0.629993156464037 0.25459715722806 no 873 0.264349530866796 1310 5403907 SGTC_371 0195-0006 7.36 µM 0.629431179196407 0.254786685425883 no 874 0.264533405494045 1222 3928593 SGTC_412 gemfibrozil 100 µM 0.627008452839527 0.255604600592357 no 875 0.26532684716516 1278 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2859 9028643 45.46 µM 0.626191811631759 0.255880608301835 no 876 0.265594568709654 1262 17151580 SGTC_2340 7987427 183.45 µM 0.625848350738377 0.255996737373673 no 877 0.26570720727441 1300 2239331 SGTC_2452 5863136 48.41 µM 0.625014964341539 0.25627863156981 no 878 0.265980618358852 1271 2184096 SGTC_617 3770-0098 35 µM 0.624992926109697 0.256286088230179 no 879 0.265987850428525 1297 5962639 SGTC_226 1,3-diallylurea 8.28947 mM 0.623125552682933 0.256918326663205 no 880 0.266601009591885 1265 74537 YKL182W FAS1 SGTC_3283 9109332 35.8195 µM 0.622153867578387 0.257247631750466 no 881 0.266920348556566 1249 17027281 SGTC_3322 9139058 2.11 µM 0.620788762154919 0.257710637770638 no 882 0.267369309123409 1360 4908926 YPR165W RHO1 SGTC_496 calpeptin 138 µM 0.620437342604819 0.257829899547039 no 883 0.267484946819327 1264 73364 A calpain inhibitor. SGTC_2379 9035213 200 µM 0.618797166517113 0.258386907112887 no 884 0.2680249945427 1376 646551 SGTC_1534 6-azauridine 81.6 µM 0.618323024205549 0.25854804301969 no 885 0.268181213825191 1319 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_979 1426-2828 121 µM 0.615980313815816 0.259344969547386 no 886 0.268953756352044 1382 747872 SGTC_3182 9108849 49.47 µM 0.615034024518978 0.259667230979569 no 887 0.269266125370035 1327 17133045 SGTC_2563 tomatine 8.54 µM 0.614325725000162 0.259908579526397 no 888 0.269500053243078 1345 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_457 grayanotoxin iii 135 µM 0.613834947559596 0.260075876649593 no 889 0.269662200493888 1280 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_948 3448-0295 75.3 µM 0.60981375172431 0.261448717375545 no 890 0.270992595450091 1340 678569 SGTC_3021 9087658 49.47 µM 0.60962392141382 0.261513617511665 no 891 0.271055480817651 1305 25237042 SGTC_2924 9010168 62.78 µM 0.607833545443838 0.262126126806561 no 892 0.271648939125207 1339 2993929 SGTC_3164 9100705 49.47 µM 0.607379960175175 0.262281420457742 no 893 0.27179939227727 1366 17174235 SGTC_1294 1000-1494 117 µM 0.60720153888893 0.262342519332902 no 894 0.271858585554152 1296 712797 YDL207W GLE1 SGTC_2641 levomentholum 100 µM 0.606394238708123 0.262619063596057 no 895 0.272126496646655 1285 16666 SGTC_2882 9058044 58.44 µM 0.604879216339307 0.263138443590951 no 896 0.272629626837891 1266 18076804 SGTC_3096 9117468 49.47 µM 0.604567480349674 0.263245377994617 no 897 0.272733209808788 1246 41316311 SGTC_2076 5212012 200 µM 0.603099583667659 0.263749206897172 no 898 0.273221221698226 1260 604802 SGTC_17 0960-0276 49.807 µM 0.602880115612499 0.263824577563345 no 899 0.27329422245249 1323 6821114 SGTC_723 4182-0001 115 µM 0.601529584317551 0.264288624442484 no 900 0.273743656636849 1297 744821 YLR208W SEC13 SGTC_789 1309-1135 70.6 µM 0.601156889545702 0.264416756690657 no 901 0.273867747541298 1330 3092424 SGTC_263 alizarin 107.927 µM 0.60070747374553 0.264571307624607 no 902 0.274017420140327 1346 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2998 9066762 71.4286 µM 0.599296458401337 0.265056844355494 no 903 0.274487604588456 1403 4945196 SGTC_375 3970-0961 9.27 µM 0.598738615636066 0.265248925338723 no 904 0.274673601039599 1340 2898222 SGTC_2514 salinomycin 42.74 µM 0.596976870404766 0.265856007539762 no 905 0.275261411558183 1403 23682228 A polyether potassium ionophore. SGTC_824 1304-0008 100 µM 0.591208858002473 0.267848529192592 no 906 0.277190244167627 1361 768245 SGTC_2287 7945887 168.79 µM 0.589523050901896 0.268432297397589 no 907 0.277755226877742 1370 1245853 SGTC_2595 hexamethylquercetagetin 100 µM 0.588990663954342 0.268616787366769 no 908 0.277933768224171 1346 386331 SGTC_1926 methyl fluorone black 53.6 µM 0.587773512775892 0.269038810385083 no 909 0.278342162468505 1258 72721 Reacts with homocysteine. SGTC_2191 5911152 200 µM 0.587556180225474 0.269114201134232 no 910 0.278415115450434 1350 2875902 SGTC_161 4065-0411 162.148 µM 0.587128812147154 0.269262482271272 no 911 0.278558599160482 1390 1906281 YLR208W SEC13 SGTC_1965 Pectolinarigenin 58.4 µM 0.586941321548305 0.269327547600989 no 912 0.278621558246408 1343 5320438 An anti-inflammatory. SGTC_844 0330-0132 15.3 µM 0.583811107421684 0.270414996846436 no 913 0.279673702213144 1375 2828079 SGTC_612 0302-0167 22.4 µM 0.582654538294915 0.270817348166893 no 914 0.280062941551246 1429 235821 SGTC_2215 7188065 200 µM 0.58118239480547 0.271329914478269 no 915 0.280558765851196 1395 940217 SGTC_1907 st060210 83.7 µM 0.580815562370342 0.271457712250929 no 916 0.280682382683604 1429 688793 SGTC_1569 carminic acid 40.6 µM 0.580500796061162 0.271567395027565 no 917 0.280788475038926 1376 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1872 amphotericin b 148 nM 0.580224620720018 0.271663648653649 no 918 0.280881576230778 1363 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_121 0557-0495 61.343 µM 0.579670212372686 0.27185692430599 no 919 0.281068517305656 1449 3104427 SGTC_2399 5884133 200 µM 0.577506588551481 0.272611852177996 no 920 0.281798644573447 1359 722445 SGTC_2212 7123476 200 µM 0.576080099287245 0.273110148890189 no 921 0.282280521033425 1364 1085715 SGTC_2729 fluphenazine 10.66 µM 0.576017014331574 0.273132195945449 no 922 0.28230184065432 1299 3372 An atypical antipsychotic. SGTC_1359 1582-0056 520 nM 0.573810165403315 0.273904004509486 no 923 0.283048134535908 1418 3661189 SGTC_984 1492-0255 2.91 µM 0.573740006525717 0.273928559077528 no 924 0.283071875806104 1391 1585198 SGTC_1190 1486-1332 13 µM 0.573438734860116 0.274034012065258 no 925 0.283173834878567 1345 4150046 SGTC_537 1334-0398 209 µM 0.571203272769488 0.274817108551057 no 926 0.283930929998014 1394 5846986 SGTC_2662 daunorubicin 22.37 µM 0.570055646035474 0.27521955751381 no 927 0.284319978422044 1343 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2544 sphondin 68.51 µM 0.569455142251347 0.275430257341379 no 928 0.284523652242566 1420 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3058 9093861 49.47 µM 0.56911059258992 0.275551185911274 no 929 0.284640545151458 1400 17217477 SGTC_1803 st050068 52.4 µM 0.568949924547264 0.275607585420815 no 930 0.284695061691252 1452 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3294 9122953 26.2835 µM 0.567832104616389 0.276000132234235 no 931 0.285074488924972 1352 16459826 SGTC_527 4476-4215 268 µM 0.56539870346771 0.276855622324607 no 932 0.285901303121932 1411 4418754 SGTC_2416 tofa 880 nM 0.565003059651686 0.27699483808777 no 933 0.286035841540224 1313 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2964 9083345 53.42 µM 0.563985184743581 0.277353156622047 no 934 0.286382107427365 1347 17741579 SGTC_1521 st012942 49.4 µM 0.563972719053546 0.277357546274749 no 935 0.286386349302461 1518 24207259 SGTC_2663 amphotericin b 100 µM 0.561937600815479 0.278074645420663 no 936 0.287079267042775 1364 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3003 9075612 71.4286 µM 0.560497459295404 0.278582643027002 no 937 0.287570086087319 1393 6501993 SGTC_1275 0867-0008 21.1 µM 0.560015618437754 0.27875270912296 no 938 0.2877343922699 1413 3422836 SGTC_969 1313-0238 134 µM 0.558729844115621 0.279206771343283 no 939 0.288173054142478 1421 5212874 SGTC_3078 9116413 49.47 µM 0.558663178201283 0.279230323744725 no 940 0.288195806854857 1318 17177322 SGTC_1067 clotrimazole 1.36 µM 0.558115008989534 0.279424023054277 no 941 0.288382926137408 1401 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2960 9079389 5.97 µM 0.556984496430505 0.279823703304572 no 942 0.288769010911615 1463 16457355 SGTC_874 0599-0792 117 µM 0.556552380586821 0.279976546320173 no 943 0.288916648364135 1435 765305 SGTC_111 0083-0039 52.457 µM 0.556329210931411 0.280055499155299 no 944 0.288992910804505 1345 759313 SGTC_2745 rifampicin 24.3 µM 0.554353676412134 0.280754872848498 no 945 0.28966841108875 1428 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_56 0957-0365 83.25 µM 0.551840352429976 0.281645852387972 no 946 0.290528868896441 1362 6752360 SGTC_539 4859-0462 2.54 µM 0.551390176913308 0.281805584577721 no 947 0.290683116527455 1454 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.549181958964058 0.282589740646833 no 948 0.291440292024064 1500 165506 SGTC_3082 9117008 49.47 µM 0.548960876027411 0.28266830671408 no 949 0.29151614975804 1412 41448529 SGTC_2955 9076254 12.21 µM 0.548566371874972 0.282808527413265 no 950 0.291651534460107 1394 16459619 SGTC_700 3453-2283 142 µM 0.548287267626915 0.28290775109059 no 951 0.29174733428309 1484 565664 SGTC_2686 alizarin 95.37 µM 0.548029695740146 0.28299933467971 no 952 0.291835756340559 1381 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2223 6903751 107.57 µM 0.545677108230815 0.283836490819357 no 953 0.292643955128325 1412 5598863 SGTC_1380 2291-0730 164 µM 0.54328700168523 0.284688210051905 no 954 0.293466106204325 1397 2999191 SGTC_2948 9070189 9.45 µM 0.542256312313676 0.285055874383902 no 955 0.293820973551556 1426 6473636 YDL196W YDL196W SGTC_2213 7173844 200 µM 0.540962899981887 0.285517576483633 no 956 0.294266577325605 1397 892728 SGTC_3250 9135583 49.47 µM 0.540475643713589 0.285691601870655 no 957 0.294434526768215 1483 7699353 SGTC_2999 9069765 71.4286 µM 0.539129967217039 0.286172477185145 no 958 0.294898589627634 1475 2097066 SGTC_1861 st057647 17.4 µM 0.538218160116923 0.286498528327918 no 959 0.295213222043428 1527 688668 SGTC_855 0428-0020 25 µM 0.538018896863173 0.286569805908113 no 960 0.295282001322544 1421 6812414 SGTC_311 1315-0136 58 µM 0.535921639490734 0.287320516295722 no 961 0.296006354117045 1491 6759207 SGTC_642 0335-0876 158 µM 0.5352474719272 0.287562031121083 no 962 0.296239371891468 1456 6812350 SGTC_2602 kawain 100 µM 0.534582144510784 0.287800473092822 no 963 0.296469416629365 1400 5369129 SGTC_2013 4024628 200 µM 0.533643733263143 0.288136942314535 no 964 0.296794022392037 1458 5230760 SGTC_831 k061-1017 217 µM 0.533626103590477 0.288143265244584 no 965 0.296800122227412 1515 1240153 SGTC_499 genistein 192 µM 0.533063962488619 0.288344912995269 no 966 0.296994652128539 1487 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_534 k292-0788 63.4 µM 0.531595731604897 0.28887190122238 no 967 0.297503010850489 1495 4146317 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.530828010343007 0.289147637746323 no 968 0.297768983943682 1414 16486 A toxic proline analog. SGTC_2516 gossypol 71.55 µM 0.530730562630251 0.289182646139031 no 969 0.297802751960137 1527 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3133 9127736 49.47 µM 0.530342357512584 0.289322129808575 no 970 0.297937291865376 1478 27243420 SGTC_1908 st060353 56.5 µM 0.53019789431007 0.28937404409221 no 971 0.297987365423369 1577 4227716 SGTC_1931 st074438 57.1 µM 0.529562612902613 0.289602390687875 no 972 0.298207610954625 1403 2787313 SGTC_2876 9059903 25.97 µM 0.528567424190425 0.289960272916632 no 973 0.298552781600276 1423 6916095 SGTC_1814 st052110 31.539 µM 0.528320111438668 0.290049241815301 no 974 0.298638587588271 1495 674163 SGTC_290 2043-6722 48.1 µM 0.528272409083214 0.290066403850178 no 975 0.298655139370353 1464 773758 YLR208W SEC13 SGTC_3215 9129942 49.47 µM 0.527863447783523 0.290213556743801 no 976 0.298797058036946 1435 17682944 SGTC_1547 harmine 94.2 µM 0.527837495888852 0.290222895962343 no 977 0.29880606495564 1451 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_937 3122-0005 46.7 µM 0.527762421305576 0.290249913585601 no 978 0.298832121191802 1457 759535 SGTC_1091 telmisartan 47.6 µM 0.527410808764436 0.290376466564765 no 979 0.298954169566351 1509 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2831 7999036 19.48 µM 0.526448433189696 0.29072297846865 no 980 0.299288335878963 1605 2988270 SGTC_3118 9124250 49.47 µM 0.526025837297058 0.290875198963691 no 981 0.299435127653967 1387 1504786 SGTC_1503 4585-0012 61.3 µM 0.525937160270093 0.290907145462184 no 982 0.299465934411206 1504 2922052 SGTC_2620 irigenin 100 µM 0.524730170351391 0.291342134705914 no 983 0.299885390380988 1549 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1351 1496-0003 46.5 µM 0.524353710045184 0.291477869977775 no 984 0.300016273139892 1476 3891978 SGTC_2742 clothiapine 36.27 µM 0.523976704243384 0.291613831485164 no 985 0.30014737144429 1493 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2433 5607874 27.82 µM 0.522875790533335 0.292011028697581 no 986 0.300530346428394 1415 2252428 SGTC_606 k015-0008 38.6 µM 0.521952655620008 0.2923442793559 no 987 0.300851647474782 1564 1970475 SGTC_1271 0832-2808 169 µM 0.521623580701416 0.292463117773755 no 988 0.300966220854006 1505 3663794 SGTC_1613 st002381 52.1 µM 0.521210713267947 0.292612247830527 no 989 0.301109995928846 1425 551167 SGTC_2263 7948595 193.29 µM 0.516859011230139 0.294186251495588 no 990 0.302627291222612 1446 2971371 SGTC_2627 acetyl isogambogic acid 100 µM 0.516250997384709 0.294406480229549 no 991 0.302839558149772 1393 6857789 A caspase activator and apoptosis inducer. SGTC_581 0958-0271 211 µM 0.514007787475545 0.295219651089879 no 992 0.303623273030408 1434 4591145 SGTC_2967 9089538 49.85 µM 0.513683968593893 0.295337121832029 no 993 0.303736481051689 1586 728216 SGTC_659 k018-0002 107 µM 0.513601042189861 0.295367208237904 no 994 0.303765475392629 1517 6797879 YHR007C ERG11 SGTC_1035 k081-0041 55.2 µM 0.509971237692051 0.296685511644876 no 995 0.305035806174298 1457 731709 SGTC_2848 9016370 25.97 µM 0.509193985416113 0.296968150645976 no 996 0.305308129268117 1512 7894410 SGTC_1139 k015-0024 46.9 µM 0.509168408240309 0.296977453589796 no 997 0.305317092484239 1469 2766652 SGTC_1744 st037937 38.9 µM 0.508506335509398 0.297218309405886 no 998 0.305549148579667 1523 1016152 SGTC_2372 9071633 200 µM 0.507270452336873 0.297668150762916 no 999 0.305982533901987 1505 21321366 SGTC_1189 1431-2119 7.28 µM 0.507210494158202 0.297689982463673 no 1000 0.306003566264317 1476 3107275 SGTC_2176 5809774 33.9695 µM 0.506904548362549 0.297801393436139 no 1001 0.30611089707427 1491 2870539 SGTC_2916 7875993 68.79 µM 0.506186707857899 0.298062871585807 no 1002 0.306362792650138 1573 1299250 SGTC_1982 st072467 71.9 µM 0.505985352643161 0.298136235337539 no 1003 0.306433466138613 1463 3163533 SGTC_393 acivicin 6.25 µM 0.505298667293103 0.298386490913502 no 1004 0.306674539360503 1462 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_567 1080-0542 68.4 µM 0.505103939313652 0.298457474965361 no 1005 0.30674291734404 1495 5950415 SGTC_358 0075-0058 9.45 µM 0.504917610384934 0.298525404510066 no 1006 0.306808352330082 1631 1069125 SGTC_3227 9130768 49.47 µM 0.504887531608554 0.298536370925448 no 1007 0.306818915970792 1499 17720899 SGTC_3060 1327-0027 12.5 µM 0.504145136502444 0.298807098674898 no 1008 0.307079695327574 1469 16000455 YPR107C YTH1 SGTC_3253 9135987 49.47 µM 0.50356984548966 0.299016965601115 no 1009 0.307281843568222 1473 4182430 SGTC_1094 duloxetine 25.4 µM 0.503509633973129 0.299038934711186 no 1010 0.307303004337687 1466 60834 A selective serotonin reuptake inhibitor. SGTC_3148 9097893 49.47 µM 0.502313911342635 0.299475364448869 no 1011 0.307723362573466 1355 17174100 SGTC_1912 st060209 90.8 µM 0.500116533524288 0.300278142700693 no 1012 0.308496512508016 1433 688787 SGTC_1642 st009582 77.7 µM 0.499873898667168 0.300366845222316 no 1013 0.308581936032443 1542 6739311 SGTC_1006 4099-6547 255 µM 0.499752341757479 0.300411288483959 no 1014 0.308624736003844 1514 3146833 SGTC_1932 st074806 40.9 µM 0.498822020203502 0.300751528107916 no 1015 0.308952386630654 1555 17251235 SGTC_2474 5321570 43.32 µM 0.498238493331209 0.300965025771206 no 1016 0.30915797701258 1548 2841384 SGTC_2117 5521686 200 µM 0.495647378852121 0.301913873011518 no 1017 0.310071609573237 1450 803312 SGTC_1767 st044992 70.3 µM 0.49540448228801 0.302002888824583 no 1018 0.310157315688667 1425 9600693 SGTC_2552 juarezic acid 87.02 µM 0.49534425929253 0.302024960943443 no 1019 0.310178566983932 1489 1549512 SGTC_687 k029-0044 34.9 µM 0.492120323591786 0.303207610119948 no 1020 0.311317142839559 1597 5829338 SGTC_105 0111-0055 734.78 µM 0.491608531684333 0.303395543078067 no 1021 0.31149805547952 1484 5179370 SGTC_2415 st077333 57.7 µM 0.489675094646172 0.304105981596831 no 1022 0.312181914099948 1729 2766255 SGTC_3039 9090270 49.47 µM 0.488698788352498 0.304465005332242 no 1023 0.31252748086535 1548 17173750 SGTC_1752 st044819 83.042 µM 0.488388054711053 0.304579313081764 no 1024 0.312637500650345 1423 441209 YML126C ERG13 SGTC_1695 st026914 34.495 µM 0.485076965420774 0.305798527425572 no 1025 0.313810875491151 1469 3289191 SGTC_1545 lovastatin 49.4 µM 0.484900926630526 0.305863409161617 no 1026 0.313873312531638 1547 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2776 terbinafine 19.92 µM 0.483849316673191 0.306251122647359 no 1027 0.314246406145572 1487 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1301 naphtanilide LB 4.81 µM 0.483820989140906 0.306261569605912 no 1028 0.314256458907778 1604 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1750 st081859 2.357 µM 0.483490068674755 0.306383621990904 no 1029 0.314373904853456 1537 5291695 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.483136081944824 0.30651420561929 no 1030 0.314499557977252 1464 6708630 An antioxidant. SGTC_3157 9099274 49.47 µM 0.482379709011152 0.306793309484428 no 1031 0.314768116380956 1514 17217662 SGTC_2740 felodipine 17.08 µM 0.48086269596522 0.307353429423965 no 1032 0.315307043572381 1586 3333 L-type calcium channel blocker SGTC_168 3970-0862 530.542 µM 0.480076124284887 0.307644028860114 no 1033 0.315586632351223 1527 3135186 SGTC_1176 0848-0131 83.3 µM 0.479162096802381 0.307981868596623 no 1034 0.315911658238976 1597 6769040 SGTC_141 0443-0274 32.331 µM 0.478953245932505 0.308059086206164 no 1035 0.315985945077409 1569 1627241 SGTC_1482 3346-2049 8.48 µM 0.47851889552414 0.308219704082345 no 1036 0.316140464368335 1543 3826804 SGTC_1398 3558-0053 112 µM 0.47821866754889 0.308330746466872 no 1037 0.316247288646239 1485 4532369 SGTC_2437 5741531 144.16 µM 0.477479407769148 0.308604244001124 no 1038 0.316510390434721 1629 2262990 SGTC_2566 crystal violet carbinol 226 nM 0.477076700212038 0.308753274926678 no 1039 0.316653752725019 1415 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2869 9037858 32.47 µM 0.475333167534378 0.309398871310527 no 1040 0.31727476100046 1451 27187042 SGTC_1441 4106-0040 13 µM 0.475158293970867 0.309463656123694 no 1041 0.317337075580758 1496 2904180 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.475033879466358 0.309509751146739 no 1042 0.317381412693677 1500 689007 SGTC_1488 4013-0813 75.9 µM 0.474020851478685 0.309885185025895 no 1043 0.317742519022898 1498 2910057 SGTC_3196 9111891 49.47 µM 0.471910375145121 0.310667976206646 no 1044 0.318495381094013 1496 18891510 SGTC_135 0933-0004 26.348 µM 0.47149369412492 0.310822627783205 no 1045 0.318644110865615 1469 21230617 YGL099W LSG1 SGTC_520 3584-0023 682 µM 0.470058429441594 0.311355583426788 no 1046 0.319156636592887 1496 1340790 SGTC_2828 7998861 71.43 µM 0.469267224462793 0.311649550153119 no 1047 0.319439319820586 1619 2988188 SGTC_1817 st052116 64.4 µM 0.469017561139992 0.311742335762701 no 1048 0.319528541805231 1571 4361398 SGTC_3318 9139014 38.6185 µM 0.467492591702333 0.312309339162927 no 1049 0.320073745584018 1527 16643984 SGTC_2418 pentamidine 31.67 µM 0.466909553924559 0.3125262377685 no 1050 0.320282294790911 1460 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1136 pergolide 1.05886 µM 0.466030293657389 0.312853458313672 no 1051 0.320596908414816 1538 47811 A dopamine receptor agonist. SGTC_3186 9110464 49.47 µM 0.465643820808808 0.312997332554677 no 1052 0.320735235490714 1570 17018021 SGTC_2430 5571206 200 µM 0.463534982824829 0.313782901819218 no 1053 0.321490472803648 1609 1731771 SGTC_847 0342-0274 5.54 µM 0.461047020639499 0.314710786175579 no 1054 0.322382435252309 1635 18097 SGTC_3073 9114972 49.47 µM 0.458650562951236 0.315605651639213 no 1055 0.323242560301963 1633 41905075 SGTC_2640 pentamidine 10.38 µM 0.458421863109244 0.31569110749892 no 1056 0.32332469365196 1612 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2650 prasterone 100 µM 0.45837644139413 0.315708080925633 no 1057 0.32334100705223 1533 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.457933106669536 0.315873768997342 no 1058 0.323500250417713 1592 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_270 tamoxifen 5.46 µM 0.457914616657636 0.315880680097883 no 1059 0.323506892629604 1662 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2691 st077356 60.2 µM 0.456813726709624 0.316292280945255 no 1060 0.323902469293721 1648 2839272 SGTC_1635 st007035 42.4 µM 0.454999059838982 0.316971245664323 no 1061 0.324554957605398 1562 3716403 SGTC_3338 9144300 39.5675 µM 0.453894770160507 0.317384722007776 no 1062 0.324952283965825 1588 4901274 SGTC_2374 9071832 200 µM 0.453640207465345 0.317480069616809 no 1063 0.325043904566974 1519 17381698 SGTC_2320 7373003 200 µM 0.452087930388776 0.318061743912589 no 1064 0.325602819155447 1472 5415828 SGTC_182 3448-4371 550.524 µM 0.452030584976936 0.318083241180994 no 1065 0.325623474529248 1680 3491403 SGTC_156 3474-0145 5.642 µM 0.451994203966524 0.318096879771122 no 1066 0.325636578965406 1664 2265471 SGTC_1120 ficusin 1.78878 µM 0.449550066067539 0.3190137075093 no 1067 0.32651745001922 1658 6199 A DNA cross-linker. SGTC_1013 4112-3890 241 µM 0.448845173819338 0.319278327880468 no 1068 0.326771674370797 1518 705171 SGTC_1238 0333-0287 48.8 µM 0.447774403549121 0.319680477011174 no 1069 0.327158009090224 1536 7226 SGTC_3126 9127922 49.47 µM 0.447590379538641 0.319749612269226 no 1070 0.327224423758819 1582 45595682 SGTC_589 1227-0070 34.1 µM 0.44692294704589 0.32000040989788 no 1071 0.327465347496251 1567 2841384 SGTC_3016 9080866 49.47 µM 0.445334803988969 0.320597508818603 no 1072 0.328038909829475 1514 17066299 SGTC_44 0929-0055 61.211 µM 0.443258548759566 0.321378825296682 no 1073 0.328789367114364 1511 1379590 SGTC_1367 1812-0510 76.9 µM 0.443134011352338 0.321425715201434 no 1074 0.328834402842142 1571 1142582 YDR527W RBA50 SGTC_2944 9067346 25.62 µM 0.441526945689988 0.322031050783366 no 1075 0.32941577929075 1603 6473075 SGTC_2839 9003951 25.97 µM 0.44123549678801 0.322140881892477 no 1076 0.329521258880251 1591 2990634 SGTC_1167 k781-0610 148 µM 0.439619197492826 0.322750258184878 no 1077 0.330106467082007 1576 4525169 SGTC_1492 4158-0558 28.5 µM 0.439029462856774 0.322972718305375 no 1078 0.330320094014562 1667 3967268 SGTC_875 0709-0210 25.7 µM 0.438957501372136 0.322999868006003 no 1079 0.330346165308717 1616 6251364 SGTC_2073 5212005 126 µM 0.436907054812288 0.323773858349083 no 1080 0.331089377705469 1555 691789 SGTC_3061 glucosamine 200 µM 0.436853165305954 0.323794210539456 no 1081 0.331108919688412 1643 91431 and experimental redox chemotherapeutic SGTC_2682 pyrogallin 40.03 µM 0.43681209608907 0.323809721306628 no 1082 0.331123812951263 1597 822798 An ATP competetive kinase inhibitor. SGTC_1675 st018485 24.5 µM 0.436423005322463 0.32395668587363 no 1083 0.331264925341744 1576 3323024 SGTC_2107 5363541 170.161 µM 0.436285686784373 0.324008559397939 no 1084 0.331314732675184 1572 244052 SGTC_3265 9137266 49.47 µM 0.435313757021667 0.324375813755852 no 1085 0.331667350308235 1704 17224265 SGTC_805 3852-0218 479 µM 0.434632065821281 0.324633500270488 no 1086 0.331914757988701 1525 6615355 SGTC_1900 st060200 72.8 µM 0.434211446904292 0.3247925405861 no 1087 0.332067450713612 1570 688945 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.432034647502364 0.325616120604794 no 1088 0.332858115767842 1594 616764 SGTC_3355 9151058 44.0485 µM 0.431993971008669 0.325631518452481 no 1089 0.332872897522992 1560 17015728 SGTC_3067 9117431 49.47 µM 0.430038254042681 0.32637219425113 no 1090 0.333583907194301 1588 17150885 SGTC_1922 5578187 25 µM 0.427564339142099 0.327310105144695 no 1091 0.334484166768533 1682 1350412 SGTC_2092 5303694 80.6725 µM 0.424490800096294 0.328476865440862 no 1092 0.335603956671296 1569 1963699 SGTC_562 3772-2733 112 µM 0.423818328445444 0.328732369167131 no 1093 0.335849155115704 1640 2876874 YIL048W NEO1 SGTC_763 3453-1109 128 µM 0.422598474488979 0.329196053587938 no 1094 0.336294119909116 1678 1560353 SGTC_2532 xanthone 78.9 µM 0.422506429244478 0.329231052013056 no 1095 0.336327704468642 1664 7020 An insecticide. SGTC_916 4466-0038 42 nM 0.421288423144599 0.329694316117732 no 1096 0.336772241407364 1663 5722064 YGL116W CDC20 SGTC_327 1273-0057 3.96 µM 0.420452510600986 0.330012403675349 no 1097 0.337077457327986 1586 3108138 SGTC_1211 1056-0033 32.3 µM 0.418720943576013 0.330671703111638 no 1098 0.337710043799665 1662 6741922 SGTC_281 1672-3440 14.9 µM 0.418356350878795 0.330810589962649 no 1099 0.337843297521661 1640 6833000 SGTC_2927 9011802 47.9 µM 0.416764745971735 0.331417163751361 no 1100 0.338425245544261 1517 43912568 SGTC_852 0418-0143 439 µM 0.414977601141904 0.332098786776448 no 1101 0.339079150163358 1657 5369229 SGTC_3320 9137005 35.139 µM 0.41451685970161 0.332274605331218 no 1102 0.339247811173864 1606 4908713 SGTC_1977 st070720 65.3 µM 0.412349384257314 0.333102207010917 no 1103 0.340041678388175 1590 682188 SGTC_1630 st005209 31.3 µM 0.41206406219872 0.333211211487165 no 1104 0.340146234391524 1672 3367314 SGTC_1082 camptothecin 424.86 nM 0.41191660274013 0.333267552441222 no 1105 0.340200275592139 1425 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2331 7980721 200 µM 0.410800505829843 0.333694109986338 no 1106 0.340609411121968 1710 2981221 SGTC_1435 4092-0789 56.7 µM 0.410627282896492 0.333760332802599 no 1107 0.340672927507422 1704 2248285 SGTC_1242 0402-0103 60.1 µM 0.408221545153021 0.334680576621374 no 1108 0.341555515930767 1569 432868 SGTC_2841 9004761 38.96 µM 0.407632281863665 0.334906133612225 no 1109 0.341771830214167 1511 2991039 SGTC_1789 tunicamycin 25 nM 0.407385121597803 0.335000758847754 no 1110 0.341862576429644 1589 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1787 fluconazole 80 µM 0.406456072128665 0.335356538809691 no 1111 0.342203763608397 1565 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2246 7293507 91.5585 µM 0.405918269877392 0.335562557977599 no 1112 0.342401326777684 1776 887656 SGTC_440 fluspirilene 35.1 µM 0.405629501615051 0.335673198592609 no 1113 0.342507424411801 1703 3396 An atypical antipsychotic. SGTC_2951 9072950 58.06 µM 0.40535884359244 0.33577691326399 no 1114 0.342606879365703 1631 16488155 SGTC_2037 5169046 200 µM 0.405334560867412 0.335786218882797 no 1115 0.342615802735771 1654 5718022 SGTC_1707 st032323 6.317 µM 0.40483155815763 0.335979002072102 no 1116 0.342800664970912 1629 3132057 YMR211W DML1 SGTC_3209 9113616 49.47 µM 0.403240128761722 0.336589224883277 no 1117 0.343385790719859 1816 16649353 SGTC_1659 st012954 42.1 µM 0.401777646076642 0.337150383688764 no 1118 0.343923837457681 1644 24207262 SGTC_2401 5128683 200 µM 0.40147329555942 0.337267209471021 no 1119 0.344035847665516 1538 708373 SGTC_449 xestospongin c 11.1929 µM 0.401454036803452 0.337274602525439 no 1120 0.344042935931524 1686 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3044 9093193 49.47 µM 0.401350183627524 0.337314470782667 no 1121 0.344081160473563 1574 25236277 SGTC_2280 7785178 200 µM 0.401140868294991 0.337394830520495 no 1122 0.344158206605786 1636 2954328 SGTC_3087 9117406 49.47 µM 0.400234128361387 0.337743029117949 no 1123 0.344492039943266 1614 42546093 SGTC_663 1486-0733 13.9 µM 0.398448591300632 0.338429101865963 no 1124 0.345149772972034 1639 722445 YPR165W RHO1 SGTC_2394 5221648 200 µM 0.397931732981297 0.338627799184947 no 1125 0.345340253990294 1768 788586 SGTC_695 3505-6186 243 µM 0.397487746878638 0.338798517903189 no 1126 0.345503910242162 1675 1819379 SGTC_2743 auranofin 4.32 µM 0.397123152921378 0.338938734025135 no 1127 0.345638323617277 1666 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_897 1000-0139 31.4 µM 0.396535612055153 0.33916473837579 no 1128 0.345854970872386 1751 6151020 SGTC_1768 st044301 37.178 µM 0.39636458242058 0.339230537772131 no 1129 0.345918045082347 1575 3931349 SGTC_1012 4112-3522 18 µM 0.396141547264187 0.339316352364959 no 1130 0.346000304890481 1742 3112398 SGTC_1754 st042065 16.137 µM 0.394655855262536 0.339888196942241 no 1131 0.346548442989 1604 1126236 YIL048W NEO1 SGTC_253 dyclonine 31.25 µM 0.394378210083895 0.339995103814108 no 1132 0.346650914373317 1700 3180 An oral anasthetic. SGTC_1820 st053765 18.6 µM 0.394300478416061 0.340025036585526 no 1133 0.346679605056639 1602 3690829 SGTC_431 k089-0097 107 µM 0.393940700156727 0.340163592485849 no 1134 0.346812410315773 1595 5499420 SGTC_2983 9022671 12.99 µM 0.39362495314198 0.34028520909219 no 1135 0.346928977793433 1779 6405161 SGTC_1738 st035555 74 µM 0.393522446385244 0.340324695299544 no 1136 0.346966824352031 1640 5331140 SGTC_3269 9137823 49.47 µM 0.393346421132774 0.340392505349513 no 1137 0.347031818264004 1602 17682936 SGTC_3069 9117009 49.47 µM 0.392218394587477 0.340827176424762 no 1138 0.347448426949377 1639 41904981 SGTC_2473 5854593 8.94 µM 0.391640922562247 0.341049779981758 no 1139 0.347661773326048 1625 2872951 SGTC_1722 st034304 3.6505 µM 0.390808624198344 0.341370711181368 no 1140 0.347969349881688 1591 4036148 YLR033W RSC58 SGTC_2908 7930301 100 µM 0.390752259867107 0.34139244921214 no 1141 0.347990182987007 1553 2223178 SGTC_1746 st038117 42 µM 0.390402069774953 0.341527518808399 no 1142 0.348119628795861 1632 2898218 SGTC_400 oxethazaine 37.5 µM 0.390330192413751 0.341555244680004 no 1143 0.348146200049962 1617 4621 A local anesthetic. SGTC_357 1325-0123 420 µM 0.389484514206517 0.3418815195662 no 1144 0.348458881983468 1745 1098503 SGTC_335 4077-0256 27.6 µM 0.3880539674558 0.34243371403401 no 1145 0.348988048218518 1729 3121989 SGTC_1988 st071872 53.4 µM 0.387040990928722 0.342824929269587 no 1146 0.349362930941535 1742 16414116 SGTC_1979 st071809 45.3 µM 0.386552183329584 0.343013768885278 no 1147 0.349543881640486 1704 4976333 SGTC_1898 st060199 18.6 µM 0.38591394144441 0.343260398044285 no 1148 0.349780202582505 1620 688866 SGTC_3055 9094636 49.47 µM 0.385141377475876 0.343559021207016 no 1149 0.350066336650451 1698 25236176 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.38402204830185 0.343991854549056 no 1150 0.350481052965567 1671 65057 A dermal irritant. YDR527W RBA50 SGTC_739 1486-1183 203 µM 0.383680405288872 0.344124005230923 no 1151 0.350607668720776 1777 4346692 SGTC_297 0986-0032 24 µM 0.38203074089243 0.344762378362967 no 1152 0.351219281473477 1641 2847425 SGTC_3117 9124945 49.47 µM 0.380533965709292 0.345341970476345 no 1153 0.351774544245846 1564 17592065 SGTC_2508 celastrol 40.54 µM 0.380006002065277 0.345546499021176 no 1154 0.351970479888566 1615 122724 Celastrol is a natural product and antioxidant. SGTC_193 1273-0060 1.558 µM 0.379395303785171 0.345783134499548 no 1155 0.352197168695989 1687 2847393 YHR072W ERG7 SGTC_828 2074-0507 139 µM 0.378141111646297 0.346269302068876 no 1156 0.352662884536265 1749 X828 SGTC_2629 bisabolol 100 µM 0.37767842732918 0.346448718295535 no 1157 0.352834747693601 1734 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1068 loratadine 26.9 µM 0.375465218491608 0.347307415681502 no 1158 0.353657254556761 1636 3957 A H1 histamine antagonist. SGTC_2747 doxorubicin 7.63 µM 0.374618047364139 0.347636315327089 no 1159 0.353972274529281 1730 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2294 7971431 200 µM 0.374567772218387 0.347655837397577 no 1160 0.353990972450958 1693 5741572 SGTC_2623 humulene 100 µM 0.374491680444982 0.347685384951813 no 1161 0.354019272551723 1623 6187145 An anti-inflammatory. SGTC_2973 9094665 17.96 µM 0.374479894154786 0.347689961824328 no 1162 0.354023656188405 1775 25237061 YIL048W NEO1 SGTC_2845 9003024 42.97 µM 0.371394911172768 0.348888689267767 no 1163 0.355171707637556 1757 2990173 SGTC_1135 dihydrocapsaicin 536.708 nM 0.368851489661885 0.349878119164594 no 1164 0.35611921162707 1574 107982 A Capsaicinoid. SGTC_2906 7926292 26.41 µM 0.368356003538534 0.350070989800743 no 1165 0.356303899355599 1649 2966319 SGTC_1485 3909-9022 254 µM 0.36804691045406 0.350191325540145 no 1166 0.356419127932707 1681 714516 SGTC_1378 2093-0007 380 nM 0.367750492111261 0.350306740894967 no 1167 0.356529643734482 1672 3618014 SGTC_1947 st076332 61.6 µM 0.367673055242446 0.350336894490833 no 1168 0.356558517069365 1764 24208416 SGTC_230 MPP+ 141.667 µM 0.366506642260884 0.350791204896109 no 1169 0.356993528553046 1622 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_547 1120-0019 610 nM 0.365835378442917 0.35105275466788 no 1170 0.357243959463814 1677 3676939 SGTC_587 k089-0003 57 µM 0.364779912976201 0.351464146629286 no 1171 0.357637850273398 1750 9659696 SGTC_264 promethazine 12.5 mM 0.364463357939896 0.351587565192948 no 1172 0.357756015528477 1674 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_553 k007-0256 45.7 µM 0.364221924416052 0.351681705878622 no 1173 0.357846148212917 1711 6287000 SGTC_2185 6113692 200 µM 0.364068652593124 0.351741474936254 no 1174 0.357903372221219 1694 874150 SGTC_542 3381-0244 89.3 µM 0.364024886239812 0.351758542501208 no 1175 0.357919712967731 1792 1112843 SGTC_491 tetrandrine 80.3 µM 0.363969889975272 0.351779989818275 no 1176 0.357940246919147 1769 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2910 7948405 25.97 µM 0.363377718874698 0.352010953216298 no 1177 0.358161371830253 1800 2971328 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.360737749140931 0.353041279078523 no 1178 0.359147751207639 1648 61125 An anti-inflammatory. SGTC_2059 5238311 157 µM 0.360443576527103 0.353156155511632 no 1179 0.35925772206169 1653 703021 SGTC_1597 7-benzyloxygramine 47.5 µM 0.359854555302562 0.353386212576452 no 1180 0.359477951520467 1655 260807 SGTC_93 0109-0045 59.227 µM 0.359699660269211 0.353446719631149 no 1181 0.359535873062175 1733 88733 SGTC_2336 9001819 198.65 µM 0.359600894037376 0.353485302878232 no 1182 0.359572807451194 1771 2989602 SGTC_300 r073-0011 5.04 µM 0.358622251492892 0.353867693065215 no 1183 0.359938849174111 1727 2735780 SGTC_41 0478-0632 82.643 µM 0.356859988701465 0.354556642980021 no 1184 0.360598312221053 1846 3750424 SGTC_3063 1327-0034 4 µM 0.353979053769609 0.35568395805298 no 1185 0.361677290458843 1737 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1625 st003711 30.1 µM 0.35259787932918 0.356224862795034 no 1186 0.362194963830609 1763 24207034 YER133W GLC7 SGTC_406 estrone 100 µM 0.351829598368686 0.356525867455175 no 1187 0.362483029849625 1822 5870 A steroid. SGTC_2204 7233102 200 µM 0.349632649248143 0.357387102473296 no 1188 0.363307202506772 1760 2172480 SGTC_2325 6158266 200 µM 0.34799514549656 0.358029500117532 no 1189 0.363921914626194 1685 3623240 SGTC_3272 9137413 49.47 µM 0.346945252842971 0.358441587887434 no 1190 0.364316224412495 1609 17614870 SGTC_2930 9013230 14.89 µM 0.345235550292404 0.359113006871012 no 1191 0.36495864728315 1809 2995857 SGTC_633 0437-0093 97.7 µM 0.34475957539235 0.359300005014475 no 1192 0.365137563014633 1684 2831118 SGTC_2254 7938975 95.19 µM 0.344020821193635 0.359590309046978 no 1193 0.365415313838479 1796 2969277 SGTC_743 1275-0778 158 µM 0.343465512119153 0.359808579061322 no 1194 0.365624140935554 1818 2849257 YMR203W TOM40 SGTC_3168 9103419 49.47 µM 0.343253641926387 0.359891868902868 no 1195 0.365703826413039 1773 16649256 SGTC_397 arbidol 50 µM 0.343197678808905 0.359913870084376 no 1196 0.365724875399231 1804 131410 A RNA synthesis inhibitor. SGTC_2393 9031399 185.94 µM 0.342230507017518 0.360294174530928 no 1197 0.36608871426432 1792 1526623 YDL150W RPC53 SGTC_326 k292-0812 17.5 µM 0.341886944562257 0.360429301031518 no 1198 0.366217987502782 1831 3579357 SGTC_2797 7859098 81.82 µM 0.337250994592104 0.362254364422479 no 1199 0.367963849239734 1693 972681 SGTC_1903 st060211 78.3 µM 0.33633193022649 0.362616551979724 no 1200 0.36831028705932 1831 688960 SGTC_1855 st056195 39.6 µM 0.334687808975722 0.363264778638763 no 1201 0.368930299322365 1832 4028379 SGTC_2391 6285546 200 µM 0.334590548135286 0.363303137902237 no 1202 0.368966987927593 1681 846083 SGTC_1063 disulfiram 1.84 µM 0.334491314960167 0.363342276459073 no 1203 0.369004421764816 1736 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_380 3970-0968 6 µM 0.33448561460624 0.363344524779015 no 1204 0.369006572153192 1705 2891601 SGTC_3129 9127257 49.47 µM 0.333693659648262 0.363656931487186 no 1205 0.369305367242891 1597 837894 SGTC_1612 st002233 45.4 µM 0.333315554294069 0.363806116722123 no 1206 0.369448049712868 1734 1035021 SGTC_1805 st050013 60.3 µM 0.332565586726407 0.364102084976527 no 1207 0.369731111922834 1781 4037144 SGTC_3176 9106582 49.47 µM 0.331760149967949 0.364420033959512 no 1208 0.370035188644837 1814 17018027 SGTC_867 0518-0118 155 µM 0.329552929855777 0.365291819477742 no 1209 0.370868896916702 1780 6848158 SGTC_646 4092-0839 27.3 µM 0.328337209593462 0.365772290178687 no 1210 0.371328356495922 1822 877796 SGTC_1553 gossypol 38.6 µM 0.326865908367769 0.366354051936237 no 1211 0.371884653577717 1739 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.324431545464754 0.367317288598972 no 1212 0.372805670176997 1680 4330530 SGTC_2843 9000894 45.46 µM 0.324296462917472 0.367370763026348 no 1213 0.372856798648557 1721 2242070 SGTC_2265 7929201 200 µM 0.32396099503802 0.367503574079744 no 1214 0.372983782250379 1663 1265108 SGTC_2237 6667747 47.222 µM 0.32359795311676 0.367647319496927 no 1215 0.373121218916522 1701 729940 YDL015C TSC13 SGTC_1107 amlodipine 47 µM 0.323243117182542 0.367787833696385 no 1216 0.373255564648462 1714 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2965 9082772 38.63 µM 0.321706530197917 0.368396522576014 no 1217 0.373837515132328 1903 16459634 SGTC_1693 xanthone 101.9 µM 0.321235151124994 0.368583316478368 no 1218 0.374016097922442 1804 7020 An insecticide. SGTC_1412 3909-8563 178 µM 0.31942128741828 0.369302387575817 no 1219 0.374703535310501 1862 23767530 SGTC_2369 9071472 200 µM 0.318907084912212 0.369506316531769 no 1220 0.374898485821495 1785 17296037 SGTC_981 1488-1094 54.9 µM 0.318517295097427 0.369660928793394 no 1221 0.375046288833684 1727 3449522 SGTC_2897 9048598 12.99 µM 0.318505299900264 0.369665687088344 no 1222 0.375050837540957 1735 6467404 SGTC_94 0334-0113 514.748 µM 0.317828228561089 0.369934302351313 no 1223 0.375307618403826 1677 6795178 SGTC_716 1683-5115 658 µM 0.314522326125562 0.371246765955684 no 1224 0.376562181199076 1864 723597 SGTC_1417 3966-0327 90.4 µM 0.313454732867629 0.371670927935845 no 1225 0.37696760345371 1775 651118 SGTC_1261 0712-0010 12.7 µM 0.312501848400646 0.37204964698988 no 1226 0.377329579266068 1879 2840123 SGTC_2551 apiole 73.87 µM 0.311715637498031 0.37236221573176 no 1227 0.377628321345404 1803 10659 A possible DNA adduct former. SGTC_1877 wortmannin 25 µM 0.310620107659338 0.372797898588283 no 1228 0.378044719579289 1865 312145 A covalent inhibitor of PI 3-kinase. SGTC_1469 k284-2957 126 µM 0.310209003360947 0.372961433286368 no 1229 0.378201012166866 1805 23884841 SGTC_468 gf-109203x 121 µM 0.309551628149955 0.373222980565314 no 1230 0.378450972815084 1863 2396 A protein kinase C inhibitor. SGTC_2407 paclitaxel 400 µM 0.309204557764838 0.373361091663692 no 1231 0.378582963540535 1834 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.308875778958259 0.373491938928666 no 1232 0.378708011051665 1762 4620898 SGTC_963 1269-2853 151 µM 0.308143613962889 0.373783378066775 no 1233 0.378986527807532 1697 3668223 SGTC_1399 3562-5772 25 µM 0.308141780279057 0.373784108057464 no 1234 0.378987225422795 1759 23847490 SGTC_799 1310-0557 151 µM 0.308056226066369 0.373818167746787 no 1235 0.379019774506249 1799 5354492 SGTC_3332 9141069 11.198 µM 0.307951090861083 0.373860024106223 no 1236 0.379059774349316 1704 17332883 SGTC_862 0452-0056 10.2 µM 0.307142248010029 0.374182089805667 no 1237 0.379367550769999 1827 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1673 st016611 27.3 µM 0.306734488453379 0.374344485150122 no 1238 0.379522738191638 1843 5226799 SGTC_2789 5281112 71.43 µM 0.303271226880572 0.375724668588266 no 1239 0.380841585940809 1701 765948 SGTC_1644 st010134 20.9 µM 0.301053385907194 0.37660936262806 no 1240 0.381686892808099 1887 3818134 SGTC_1249 0481-0015 10.2 µM 0.299401646542258 0.377268661031184 no 1241 0.382316802998838 1728 4227577 SGTC_367 0335-0881 7.1 µM 0.298808257741262 0.377505602038196 no 1242 0.382543174939651 1859 23828853 SGTC_1665 st014639 11.4 µM 0.298597471415714 0.377589780426526 no 1243 0.38262359749771 1834 981133 YIL048W NEO1 SGTC_23 0213-0011 39.996 µM 0.296707584031318 0.378344774089097 no 1244 0.383344883215623 1901 627608 SGTC_860 0443-0016 25.1 µM 0.296386419414437 0.378473122849194 no 1245 0.383467497707078 1823 5337942 SGTC_1369 1866-0067 208 µM 0.296117325493006 0.378580672638605 no 1246 0.383570241592984 1886 3531355 SGTC_2129 girgensonine 121.053 µM 0.2949850267587 0.379033325731836 no 1247 0.384002658978811 1832 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2676 harmalol 100 µM 0.293898405168355 0.379467874759383 no 1248 0.384417768405137 1863 5459187 A monoamine oxidase inhibitor SGTC_2684 capsaicin 100 µM 0.292866193819961 0.379880805749329 no 1249 0.384812214922112 1819 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.292764677935336 0.379921424078085 no 1250 0.384851014381439 1810 364106 SGTC_2605 digitonin 300 nM 0.29209178337914 0.380190694747607 no 1251 0.385108224402722 1950 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2716 st080858 38.6235 µM 0.291981522800506 0.380234823011713 no 1252 0.385150375689984 1881 5296050 SGTC_1290 0986-0249 10.2 µM 0.291867170568611 0.380280590475723 no 1253 0.385194092600369 1885 53329 SGTC_2370 9071495 200 µM 0.290899981293061 0.380667757908947 no 1254 0.385563907810227 1762 21791103 SGTC_2449 5812982 45.77 µM 0.290704896760419 0.380745865063241 no 1255 0.385638513099123 1799 776185 SGTC_196 k015-0023 18.111 µM 0.288299984772418 0.381709132342181 no 1256 0.38655855940463 1795 5211998 SGTC_3321 9137793 26.8275 µM 0.287662931349289 0.381964421779153 no 1257 0.386802383808517 1802 4904192 SGTC_1315 1237-0019 3.69 µM 0.287195505480205 0.382151768220462 no 1258 0.386981313769168 1893 825140 SGTC_14 0354-0009 295 µM 0.287064672303492 0.382204211705181 no 1259 0.387031400828283 1839 1713507 SGTC_2651 TUB2.036 5 µM 0.286088563442147 0.382595545671531 no 1260 0.387405145351074 1897 15992207 YFL037W TUB2 SGTC_1484 3473-2379 286 µM 0.284132238281784 0.383380220962276 no 1261 0.388154521024277 1897 671917 SGTC_3301 9125354 19.7965 µM 0.282656868931423 0.383972303310472 no 1262 0.388719941009297 1762 41905162 SGTC_1832 st054113 55 µM 0.281662897827566 0.384371347952677 no 1263 0.389101003151484 1927 1251267 SGTC_528 3492-0019 172 µM 0.28113665116587 0.384582667240117 no 1264 0.389302795376908 1824 2869262 SGTC_2060 5238662 140 µM 0.27872268843469 0.385552455272373 no 1265 0.390228824695717 1786 790130 SGTC_2347 9049783 174.81 µM 0.277100739160881 0.386204461481336 no 1266 0.39085137713565 1887 6467988 YPL169C MEX67 SGTC_1578 josamycin 24.2 µM 0.276485289276829 0.386451949973953 no 1267 0.39108767845913 1755 5282165 A P450 substrate. SGTC_2186 6124449 200 µM 0.275314440987255 0.386922906156727 no 1268 0.391537335358063 1889 3834182 YLR033W RSC58 SGTC_2217 6934799 96.0675 µM 0.275140801226114 0.386992764346326 no 1269 0.391604032970635 1908 675606 SGTC_782 0083-0095 30.5 µM 0.274999824902569 0.387049484179667 no 1270 0.391658186415344 1811 3591729 An indicator and reagent. SGTC_2658 polymyxin b sulfate 77.05 µM 0.274683339270115 0.387176826489115 no 1271 0.391779766157407 1814 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1799 st045822 46.1415 µM 0.274283384996059 0.387337770912196 no 1272 0.391933425966694 1922 3674992 SGTC_1234 0326-0494 15.5 µM 0.273735187715552 0.387558400826703 no 1273 0.392144067150201 1908 1547813 SGTC_2142 5622915 118.518 µM 0.273183750739758 0.38778037124247 no 1274 0.392355985057251 1818 5322196 SGTC_115 0527-0192 112.043 µM 0.273163475618308 0.387788533304628 no 1275 0.392363777420204 1810 4233931 SGTC_2226 7298446 200 µM 0.272145769006146 0.388198290396515 no 1276 0.392754969272568 1925 3283010 SGTC_1332 1480-0653 17.5 µM 0.271512378046002 0.388453374156104 no 1277 0.392998490421031 1960 5749438 SGTC_2713 st079149 53.4 µM 0.271431190391522 0.388486074113073 no 1278 0.393029707838739 1836 3103253 SGTC_2937 9044753 11.33 µM 0.270726757487868 0.388769831755325 no 1279 0.393300597783287 1820 6465530 YGL099W LSG1 SGTC_372 0155-0182 15.9 µM 0.270195090621136 0.388984035591154 no 1280 0.393505084701334 1884 771486 SGTC_2614 arthonioic acid 13.39 µM 0.269322083279635 0.389335835637935 no 1281 0.393840919898512 1809 6710684 SGTC_2593 nobiletin 86.24 µM 0.267973519067012 0.389879451388834 no 1282 0.394359851110683 1778 72344 An anti-infammatory. SGTC_746 1095-0025 46.6 µM 0.267659401949847 0.390006105194 no 1283 0.394480751204751 1897 6749286 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.26735959539135 0.390126999793255 no 1284 0.394596152809396 1799 2724 A muscle relaxant with antifungal properties. SGTC_761 k216-0224 480 µM 0.265708242723189 0.390793084744113 no 1285 0.395231957372989 2001 1340404 SGTC_3093 9117344 49.47 µM 0.264627244688823 0.391229286786454 no 1286 0.395648314951455 1849 24824913 SGTC_1881 5652484 16 µM 0.264109494107389 0.391438256908607 no 1287 0.395847774163059 1949 2255129 SGTC_2091 4-phenylthiadiazole 200 µM 0.263237066491159 0.391790449642967 no 1288 0.396183931504081 1828 270010 SGTC_3083 9117465 49.47 µM 0.262402364620508 0.392127495800308 no 1289 0.396505624917034 1769 16420915 SGTC_1497 4476-2978 41.3 µM 0.261549578692696 0.392471927763974 no 1290 0.396834360683235 1896 1528379 SGTC_522 1273-0010 11.6 µM 0.261267799434776 0.392585754202612 no 1291 0.396942998351804 1867 5705015 SGTC_922 1866-0035 480 µM 0.260057390862106 0.393074810474133 no 1292 0.397409752262336 1845 3156169 SGTC_2717 st081029 62.2815 µM 0.259442864468376 0.393323169792955 no 1293 0.397646780259902 1979 5292846 SGTC_2457 5731572 11.68 µM 0.259372033697166 0.39335179866601 no 1294 0.397674102714645 1960 2865357 SGTC_3326 9140064 16.379 µM 0.256206724521831 0.394631761825439 no 1295 0.398895608235741 1795 1868434 SGTC_650 1328-0195 38 µM 0.254623483370063 0.395272408561773 no 1296 0.399506959881279 1958 2780821 SGTC_1297 1068-0111 14.1 µM 0.254496393246666 0.395323846933579 no 1297 0.399556045080749 1793 767057 SGTC_519 k048-0011 62.8 µM 0.254404709310809 0.395360956161184 no 1298 0.399591456562378 1879 6836379 SGTC_2461 5755302 26.15 µM 0.253076258299088 0.395898755267314 no 1299 0.400104642469245 1966 2788904 SGTC_3266 9136860 49.47 µM 0.252752063331212 0.396030029802781 no 1300 0.400229906501022 1843 4871271 YPR165W RHO1 SGTC_1867 st057372 64 µM 0.252317602066806 0.39620597236799 no 1301 0.400397791854971 1907 688837 SGTC_1089 terbinafine 2.25 µM 0.251849115182189 0.396395717884803 no 1302 0.400578846076934 1972 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_228 caffeine 993.056 µM 0.251546824831435 0.396518163880426 no 1303 0.400695682342027 1959 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3243 9134147 49.47 µM 0.250729649714202 0.396849220608821 no 1304 0.401011567791843 1982 24282180 SGTC_1539 benzyladenosine 56 µM 0.250457937800418 0.396959313935896 no 1305 0.401116614511855 1859 92208 A nucleotide analog. SGTC_2851 9015922 71.43 µM 0.248140887026429 0.397898478667998 no 1306 0.402012700696309 1945 2996893 SGTC_1882 5615643 20 µM 0.246616433948269 0.39851670485503 no 1307 0.402602542435643 1965 2253075 SGTC_89 0302-0250 142.109 µM 0.245266151173224 0.399064510909188 no 1308 0.403125179434491 1950 4203518 YLR208W SEC13 SGTC_3112 9123419 49.47 µM 0.244974879023848 0.399182705339711 no 1309 0.403237941217817 1927 17015854 SGTC_652 0437-0092 114 µM 0.244373048141549 0.399426949712208 no 1310 0.403470956783725 1837 3091274 SGTC_405 ebelactone b 50 µM 0.244316952541012 0.399449717308819 no 1311 0.403492677503096 1864 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1508 1080-0625 72.9 µM 0.243422428138936 0.399812825282516 no 1312 0.40383908554955 1924 767111 SGTC_3062 9077494 49.47 µM 0.240511138340424 0.400995182986024 no 1313 0.404967014749316 1946 16459633 SGTC_2097 5376186 200 µM 0.240004870584087 0.401200885662441 no 1314 0.40516324038399 1975 742755 SGTC_2655 perillic acid 100 µM 0.23864795784435 0.401752350554652 no 1315 0.405689287183991 1861 5702197 An apoptosis inducer. SGTC_2534 helenine 20.12 µM 0.237218441000971 0.402333534257037 no 1316 0.406243665357304 1854 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2504 purpurogallin 52.29 µM 0.236759822776654 0.402520035687271 no 1317 0.406421561096329 1840 5281571 An antioxidant. SGTC_1150 3909-7983 10.9 µM 0.235953592676579 0.402847950532815 no 1318 0.40673434056845 1866 23965914 SGTC_2996 9066192 71.4286 µM 0.232891142673404 0.404094149993981 no 1319 0.40792296824004 1810 6472854 SGTC_921 1561-0023 372 µM 0.232526684987735 0.404242523461346 no 1320 0.408064481751275 1812 24050882 SGTC_1327 1436-0082 2.18 µM 0.232473305686384 0.40426425573376 no 1321 0.408085209149243 1893 15992205 SGTC_423 5-fluorouracil 457 µM 0.231869152428698 0.404510244746744 no 1322 0.40831982221214 1757 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3218 9131285 49.47 µM 0.230935361444819 0.404890524366363 no 1323 0.408682509340527 2002 17156417 SGTC_1962 st076595 64.5 µM 0.229990828013439 0.405275270165287 no 1324 0.409049448440716 1885 279619 SGTC_3090 9117696 49.47 µM 0.22916105874192 0.405613343548159 no 1325 0.409371868929281 1998 7923821 SGTC_894 0960-0238 55.9 µM 0.229073650000573 0.40564896064717 no 1326 0.409405836605689 2015 6741907 YDL195W SEC31 SGTC_474 dl-dihydrosphingosine 5 µM 0.228580011504494 0.405850121902569 no 1327 0.409597680896554 1978 3058739 A sphingolipid protein kinase C inhibitor. SGTC_217 ketoconazole 989 nM 0.228358089185678 0.405940564956063 no 1328 0.409683934325995 1940 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_458 nppb 133 µM 0.228009903900266 0.406082475807959 no 1329 0.409819270554189 2046 4549 A chloride channel blocker. SGTC_145 3737-0113 38.366 µM 0.227406936284076 0.406328258186879 no 1330 0.410053663598057 2035 6849351 SGTC_1570 verbenone 133 µM 0.226531433344246 0.406685197428062 no 1331 0.41039405714549 2031 29025 A natural terpanoid with antifungal properties. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.22628412097916 0.406786039803118 no 1332 0.410490223869851 1917 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2262 9014885 67.46 µM 0.225455803373427 0.407123833828765 no 1333 0.410812352031017 2019 6457424 SGTC_854 0422-0053 192 µM 0.22527688443188 0.407196807374557 no 1334 0.410881940531713 1981 3596728 SGTC_2345 9052315 157.45 µM 0.224315260558063 0.407589068616772 no 1335 0.411256001269138 1889 6469265 SGTC_490 phenamil 164 µM 0.224031492967776 0.407704839528977 no 1336 0.411366399065291 2009 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_684 1140-0066 328 µM 0.223986106010663 0.407723357153443 no 1337 0.411384057194771 1892 6813534 SGTC_345 1362-0200 395 µM 0.2231620556039 0.408059600918835 no 1338 0.411704691249502 1839 1419823 SGTC_3261 9137475 49.47 µM 0.222596441056452 0.408290432277209 no 1339 0.411924803293827 1993 17027690 SGTC_610 4215-0184 155 µM 0.22075519090917 0.409042079726634 no 1340 0.41264152762875 1928 5605015 SGTC_2285 7945142 200 µM 0.220736789987128 0.409049593167271 no 1341 0.412648691839093 1893 2970608 SGTC_886 0866-0150 153 µM 0.217915366807528 0.410202026804498 no 1342 0.413747526938355 2057 271463 SGTC_2536 dehydroabietamide 32.04 µM 0.215060850650133 0.411368767244511 no 1343 0.414859938180258 2016 3983547 SGTC_39 0986-0283 58.349 µM 0.214876438326202 0.411444170082145 no 1344 0.414931827653657 2028 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_504 lovastatin 124 µM 0.214140717883342 0.411745025289756 no 1345 0.41521866195269 1861 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_8 0354-0001 70 µM 0.212503231583588 0.412414822016351 no 1346 0.415857228457936 1939 4993152 SGTC_2313 7726885 200 µM 0.212098136983338 0.412580561190836 no 1347 0.416015236556853 1922 726423 SGTC_3281 9140613 49.47 µM 0.211781352743002 0.412710180195619 no 1348 0.416138808453698 1842 16013766 SGTC_945 3381-0768 11.3 µM 0.211510773571758 0.412820900952469 no 1349 0.416244363140417 2034 1126236 YIL048W NEO1 SGTC_3270 9137563 49.47 µM 0.210687168214411 0.413157962186589 no 1350 0.41656569407212 2007 17015724 SGTC_1268 0828-0275 2.46 µM 0.210291276713892 0.413320003938365 no 1351 0.416720171623812 1983 745337 SGTC_2810 7959871 45.46 µM 0.21023118730315 0.413344600335641 no 1352 0.41674361974111 1979 2974535 SGTC_1292 0kpi-0043 232 µM 0.209564451414888 0.413617538123993 no 1353 0.417003813583186 1917 3333905 SGTC_2823 7987624 58.44 µM 0.207453098209742 0.414482125273728 no 1354 0.417828009022072 1946 2239440 SGTC_418 lividomycin a 100 µM 0.207307774821908 0.414541649670434 no 1355 0.417884751304987 2034 72394 An antibiotic. SGTC_2489 cantharidin 73.42 µM 0.206822691757037 0.414740353684994 no 1356 0.418074166915086 1897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1843 st055809 45.5 µM 0.206567144681211 0.414845041915406 no 1357 0.418173960780443 1935 16413835 SGTC_2622 2-methoxyxanthone 59.94 µM 0.206443620035746 0.414895647584421 no 1358 0.418222200364224 2035 71034 A hepatoprotective. SGTC_1697 st025554 27.742 µM 0.20403970364991 0.415880766021517 no 1359 0.419161236235509 1925 1269519 SGTC_3249 9135183 49.47 µM 0.201680498249434 0.416848076253028 no 1360 0.420083254728438 1987 4902779 SGTC_2335 9018011 154.17 µM 0.201178431573737 0.417053996449045 no 1361 0.420279527910146 2043 6458208 SGTC_755 1995-0008 37.3 µM 0.200178680393095 0.41746410723596 no 1362 0.420670420147447 2053 689533 SGTC_711 k292-0785 179 µM 0.199723662298257 0.417650791270839 no 1363 0.420848353385014 1982 4146315 SGTC_698 k064-0052 127 µM 0.195577943107762 0.419352539614801 no 1364 0.422470262854874 2027 5088751 SGTC_67 0335-0847 266 µM 0.195395996590945 0.419427260427193 no 1365 0.422541475234042 2096 4552207 YOR254C SEC63 SGTC_1864 st057645 30.4 µM 0.193789769979025 0.420087022643403 no 1366 0.423170248771554 2094 688666 SGTC_416 estradiol valerate 100 µM 0.193181258765216 0.420337029150648 no 1367 0.423408507808105 1961 13791 A steroid. SGTC_565 1418-0001 44.5 µM 0.191989967378053 0.420826563550326 no 1368 0.423875032056186 2048 2862145 SGTC_2918 7977171 22.06 µM 0.19165107863618 0.42096584466082 no 1369 0.424007764548145 1971 2236483 SGTC_2657 nystatin 74.44 µM 0.191094896273829 0.421194453496055 no 1370 0.424225623071032 2032 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1154 4088-0362 150 µM 0.190374799056214 0.42149047606826 no 1371 0.424507721988975 2044 6618304 SGTC_2405 ticlatone 3.52 µM 0.189046541099802 0.42203662189085 no 1372 0.42502816993854 1968 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_482 fipronil 114 µM 0.188531565433032 0.422248407161075 no 1373 0.425229986758355 2083 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_101 0490-5701 117.494 µM 0.187472157611839 0.422684162404872 no 1374 0.425645225835334 2078 4661669 SGTC_1509 1326-1131 80 µM 0.186611853427559 0.423038092061405 no 1375 0.425982486160534 2077 768313 SGTC_2198 6589944 200 µM 0.185681097635836 0.423421075508028 no 1376 0.426347426217333 2029 5290268 SGTC_876 0720-0963 56.8 µM 0.184242708604534 0.424013079930109 no 1377 0.426911528151101 2112 765861 SGTC_2564 betulinic acid 100 µM 0.181343916979282 0.425206668807238 no 1378 0.428048818333708 2144 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_465 cgp-37157 41 µM 0.180060793399781 0.42573521964723 no 1379 0.428552420906299 2105 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2093 5331342 194.4 µM 0.179851920477483 0.425821272308265 no 1380 0.42863441074814 2091 33839 SGTC_2968 9090663 33.37 µM 0.179751657072366 0.425862580654486 no 1381 0.428673768694653 1947 25236811 SGTC_882 0843-0131 351 µM 0.17916925961964 0.426102543453353 no 1382 0.428902400197176 2108 5425421 SGTC_3254 9136651 49.47 µM 0.178359953723111 0.426436043809345 no 1383 0.429220148640347 2023 16454030 SGTC_2808 7946468 45.46 µM 0.17751547693775 0.426784093538253 no 1384 0.429551754723986 2004 2970879 SGTC_2032 5185112 25.99 µM 0.177177774892227 0.426923292859096 no 1385 0.429684376267424 2065 5718189 SGTC_839 0122-0028 230 µM 0.176843873838169 0.427060934375532 no 1386 0.429815512896546 2010 759448 SGTC_1717 st033143 58.0435 µM 0.176684228537604 0.427126746894384 no 1387 0.429878214886431 2083 674616 SGTC_1957 st077035 62.4 µM 0.176069177490392 0.427380315792833 no 1388 0.430119797705111 2123 705593 SGTC_2468 5987765 72.9 µM 0.174632527396989 0.4279727244535 no 1389 0.430684194071055 2043 26772094 SGTC_2836 9010338 19.48 µM 0.174345578488585 0.428091068532335 no 1390 0.430796940626675 1861 2994051 SGTC_3091 9116372 49.47 µM 0.173346221791992 0.428503275768973 no 1391 0.43118964692364 2027 17169793 SGTC_3235 9132602 49.47 µM 0.17260964076497 0.42880714521258 no 1392 0.43147913670785 2026 4912240 SGTC_1996 st072960 66.8 µM 0.171554623550598 0.429242455927387 no 1393 0.431893841803363 2118 1719405 SGTC_569 4130-2812 160 µM 0.171054146597826 0.429448987882223 no 1394 0.432090595054188 2135 743552 SGTC_669 0108-0021 26.2 µM 0.169969377421874 0.429896706082353 no 1395 0.432517109736299 2197 17201 SGTC_390 dec-rvkr-cmk 16.7 µM 0.169697797212353 0.43000880987199 no 1396 0.432623903258045 2027 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2994 9053520 71.4286 µM 0.169668765871571 0.430020793860186 no 1397 0.432635319547349 2086 4647384 SGTC_3145 9085516 49.47 µM 0.169656542906201 0.430025839456727 no 1398 0.432640126125117 1887 25236195 SGTC_1990 st072050 59.8 µM 0.168383529753331 0.430551397167936 no 1399 0.433140782228776 1938 17233948 SGTC_1758 st042942 75.2445 µM 0.168175912129184 0.430637122857049 no 1400 0.433222445184051 2121 669317 SGTC_1761 st044296 37 µM 0.16770370397618 0.4308321106153 no 1401 0.433408191055822 2034 1826700 SGTC_706 4262-0057 46.9 µM 0.167231078264134 0.431027287680117 no 1402 0.433594115906414 2023 883298 SGTC_2744 captopril 92.04 µM 0.166098672487675 0.431494998131444 no 1403 0.434039649423485 2123 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_25 0118-0223 35.662 µM 0.165898712608894 0.431577596302834 no 1404 0.434118330322725 2095 5333628 SGTC_1384 3089-0840 101 µM 0.164692913930094 0.432075743341727 no 1405 0.43459284734203 2115 1069836 SGTC_2982 9019404 25.97 µM 0.164588895645382 0.432118721093482 no 1406 0.434633786002109 1819 22333232 SGTC_905 2-aminofluorene 215 µM 0.164434254048514 0.432182616615494 no 1407 0.434694649864008 2116 1539 An established DNA mutagen. YPR165W RHO1 SGTC_987 1497-1013 404 µM 0.163074217331027 0.432744639023392 no 1408 0.43522999981307 2101 1676435 SGTC_2630 antimycin a 100 µM 0.162718248980445 0.432891762119351 no 1409 0.435370138940192 2052 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2010 4012422 159 µM 0.162123761529322 0.433137486813237 no 1410 0.435604197366345 2054 952393 SGTC_2179 6298986 200 µM 0.159809090943429 0.434094475273172 no 1411 0.436515731293845 2120 738374 SGTC_2195 6536160 144.242 µM 0.159500908223584 0.434221921078326 no 1412 0.43663712140964 2005 3834386 SGTC_2279 7948423 32.93 µM 0.158741296473594 0.434536079899941 no 1413 0.436936350398177 2144 1247112 SGTC_1448 4255-0083 152 µM 0.1583735208751 0.434688198717301 no 1414 0.437081238857572 2102 5399660 SGTC_1309 pyrazolanthrone 13.4 µM 0.157693858951537 0.434969344940022 no 1415 0.437349019896532 2140 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2856 9022925 19.48 µM 0.155762534201367 0.435768427994811 no 1416 0.438110101738127 2045 4944862 SGTC_3159 9100096 49.47 µM 0.155663351169304 0.435809471951679 no 1417 0.43814919324227 2106 25236875 SGTC_2698 st077697 67.5 µM 0.155569609226457 0.435848264910645 no 1418 0.43818614077752 1977 3154499 SGTC_1462 k081-0014 26.5 µM 0.155318855883932 0.435952036478935 no 1419 0.438284975577216 2094 3270634 SGTC_244 nsc-207895 1.295 µM 0.153918889392844 0.436531478357082 no 1420 0.438836845002324 2046 42640 SGTC_3349 9149703 23.001 µM 0.152458649999195 0.437136012133361 no 1421 0.439412600823915 2124 4910494 SGTC_2803 7707263 71.43 µM 0.152437192518174 0.437144896550089 no 1422 0.439421062223814 2012 2199229 SGTC_2730 imipramine 71.33 µM 0.151075279479572 0.437708857925957 no 1423 0.439958166388052 2150 3696 A tricyclic antidepressant. SGTC_2286 7945697 125 µM 0.150458369014977 0.437964359180839 no 1424 0.440201496749681 1987 1245733 SGTC_2162 5663267 200 µM 0.149974566397592 0.438164750241786 no 1425 0.440392340679355 2127 6456493 SGTC_607 4491-0986 66.8 µM 0.149292211264518 0.438447408703534 no 1426 0.440661530455287 2129 698981 YDR232W HEM1 SGTC_2546 rhodinyl acetate 100 µM 0.148576158624502 0.438744059767159 no 1427 0.440944043417654 2165 6708682 SGTC_3207 9114163 49.47 µM 0.147153565970926 0.439333522885058 no 1428 0.441505405249275 2165 849233 SGTC_1239 0337-0584 35.4 µM 0.146304960914649 0.439685213612545 no 1429 0.441840324878469 2140 914301 YML130C ERO1 SGTC_3110 9122132 49.47 µM 0.145451016522646 0.440039165196346 no 1430 0.44217739376488 2125 918317 SGTC_656 4090-1979 187 µM 0.145282888152981 0.44010885841406 no 1431 0.442243762327045 2164 22330961 SGTC_3032 9089427 49.47 µM 0.145140105911029 0.440168046514774 no 1432 0.442300126795195 2047 17173707 SGTC_3169 9102970 49.47 µM 0.143665099594108 0.440779564867462 no 1433 0.442882465865792 2159 17027839 SGTC_2898 9056270 58.44 µM 0.143140130591777 0.440997244316087 no 1434 0.44308975581173 2075 19154699 SGTC_729 4092-0585 94.1 µM 0.141134214797077 0.441829164963483 no 1435 0.443881957333018 2013 2169061 SGTC_931 2812-0076 566 µM 0.140591453956158 0.442054310385041 no 1436 0.444096349966174 2027 3450959 SGTC_3221 9128209 49.47 µM 0.139592993601842 0.442468535712471 no 1437 0.444490788356803 2061 16460723 SGTC_693 4161-2696 114 µM 0.138792188920343 0.44280080628268 no 1438 0.444807183291273 2122 805759 SGTC_147 4466-0538 29.23 µM 0.137970605310521 0.443141740275584 no 1439 0.445131824449239 2060 6742687 YHR072W ERG7 SGTC_360 0957-0399 1.01 µM 0.137784733677103 0.443218877602244 no 1440 0.445205275016968 2135 6752301 YPR165W RHO1 SGTC_2040 5100729 123 µM 0.137598883272785 0.443296008270321 no 1441 0.445278719076422 2086 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1467 k284-1082 293 µM 0.137483963317594 0.443343702827567 no 1442 0.445324133896667 2185 3334705 SGTC_2517 totarol 10 µM 0.137170572076071 0.443473771931974 no 1443 0.445447985543946 2013 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2144 5628481 200 µM 0.135136693983505 0.444318054935626 no 1444 0.446251899329654 2054 2818399 SGTC_3287 9117173 37.0625 µM 0.134811216630177 0.444453187376083 no 1445 0.446380568605908 2192 2789709 SGTC_2122 5258151 111.688 µM 0.134799113159364 0.44445821264771 no 1446 0.446385353517296 2071 2173356 SGTC_2522 biochanin a 4.94 µM 0.133210493267156 0.445117873076559 no 1447 0.447013456190744 2140 5280373 A possible chelator. SGTC_2015 5119600 184 µM 0.132933084461347 0.445233080282133 no 1448 0.447123150738496 2155 2828786 SGTC_265 mycophenolic acid 32.932 µM 0.132388002554148 0.445459464943488 no 1449 0.447338701862668 2147 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1954 st077032 68.9 µM 0.132245919181462 0.445518478259242 no 1450 0.447394890895572 1940 698907 SGTC_382 3229-0966 23.2 µM 0.132075841316336 0.445589120475089 no 1451 0.447462152164948 2161 5722370 SGTC_57 miconazole 162.5 nM 0.131454669824411 0.445847140082124 no 1452 0.44770782178073 2138 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2543 pimpinellin 60.67 µM 0.129803116518651 0.446533266629072 no 1453 0.448361098576487 2030 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1476 4112-3294 3.34 µM 0.129061352973487 0.446841479453717 no 1454 0.448654551025528 2143 704369 SGTC_3314 9135860 59.4275 µM 0.127623387597278 0.447439064894088 no 1455 0.449223510927336 2180 25252478 SGTC_252 miconazole 1.30953 nM 0.127148787696385 0.447636323990819 no 1456 0.449411318893663 2168 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2981 9013952 38.96 µM 0.127029669621295 0.447685835357661 no 1457 0.449458457901919 1937 2996344 SGTC_368 fentichlor 4.58 µM 0.126807820343745 0.447778049068291 no 1458 0.449546252985394 2058 7329 A pesticide. SGTC_433 pimozide 108 µM 0.126637450515287 0.447848866784539 no 1459 0.449613677164101 2046 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1426 4048-4480 71.7 µM 0.126473837981875 0.447916877257148 no 1460 0.449678428499966 2167 14224343 SGTC_3127 9126946 49.47 µM 0.125406549542484 0.448360565292406 no 1461 0.450100851632792 2012 27243249 SGTC_1714 st033236 13.627 µM 0.124330678123004 0.448807886786561 no 1462 0.450526729057276 2150 2916566 SGTC_1093 fluphenazine 7.97 µM 0.124129983769387 0.448891337897935 no 1463 0.450606179065742 2120 6602611 An atypical antipsychotic. SGTC_917 harmaline 728.087 nM 0.123094003707794 0.449322146672439 no 1464 0.451016329759258 2122 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_630 4356-0227 183 µM 0.12285980601399 0.44941954528258 no 1465 0.451109057289349 2180 779312 SGTC_939 1165-0479 45.3 µM 0.122529940400656 0.44955673562834 no 1466 0.451239667812049 2208 1377347 SGTC_1440 4100-1550 40 µM 0.122194132166338 0.44969640369003 no 1467 0.451372636742333 2164 742806 SGTC_1054 3429-0080 167 µM 0.121579885659154 0.449951894833674 no 1468 0.451615872107356 2153 1162877 SGTC_1187 1391-0724 117 µM 0.12102811529728 0.450181417192965 no 1469 0.451834383045328 2086 6997986 SGTC_1600 coumarin 106 71.1 µM 0.119548731924036 0.450796884868576 no 1470 0.452420317168075 2137 100336 A hepatotoxic, DNA x-linker. SGTC_1017 4239-0030 168 µM 0.118593956266864 0.45119416298276 no 1471 0.45279852688021 1996 1149593 SGTC_880 0833-0487 87.2 µM 0.118209506889693 0.451354144572603 no 1472 0.45295082868303 2175 76075 SGTC_1400 3771-8998 51.5 µM 0.116859858221027 0.451915838616808 no 1473 0.453485554317868 2157 670767 SGTC_3257 9139206 32.98 µM 0.116405182814472 0.452105086238656 no 1474 0.453665714013958 2182 4910041 SGTC_266 formosanin C 406 nM 0.116124656330669 0.452221854022186 no 1475 0.453776874039507 2195 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2506 ethyl hematommate 54.16 µM 0.115966353988264 0.452287748426473 no 1476 0.453839603735145 2012 3940691 An allergen. SGTC_3313 9133968 57.047 µM 0.1153611876468 0.452539665046171 no 1477 0.454079420646441 2207 1494643 SGTC_1494 4358-1428 177 µM 0.113887916795987 0.45315303298091 no 1478 0.454663322120687 2229 1564571 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.113566639886988 0.453286805329233 no 1479 0.454790666862556 2140 5711223 A potent inhibitor of glutathione S-transferases. SGTC_159 3970-0959 50 µM 0.112562902949092 0.453704772489362 no 1480 0.455188548614693 2165 6615653 SGTC_3180 9109287 49.47 µM 0.111692855110542 0.454067111538503 no 1481 0.455533472338441 2138 18891271 SGTC_2070 5230947 200 µM 0.111234016075795 0.454258214493708 no 1482 0.455715389035008 2210 2835538 SGTC_970 1315-0089 19.5 µM 0.1109433141155 0.454379295123556 no 1483 0.455830648945388 2205 6811083 YLR033W RSC58 SGTC_955 1216-0110 33 µM 0.108228738900571 0.455510149307262 no 1484 0.456907124250303 2164 3619719 SGTC_1974 st069448 26.9 µM 0.106988174661377 0.456027071667314 no 1485 0.457399180579482 2222 6323587 YNR016C ACC1 SGTC_1215 3852-0577 11.2 µM 0.105725413836732 0.456553319418146 no 1486 0.457900108014772 2193 2884876 SGTC_325 2810-4341 181 µM 0.105440162243596 0.456672206837707 no 1487 0.45801327440037 2223 774970 SGTC_1885 st057546 99.9 µM 0.104780264141639 0.456947254618282 no 1488 0.45827508538286 2204 702008 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.103849780752383 0.457335118285656 no 1489 0.458644280340005 2242 4000243 SGTC_1776 st049249 45.9 µM 0.103181431338054 0.457613738855057 no 1490 0.458909488445131 2080 1822314 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.103143817755473 0.457629419773248 no 1491 0.458924414456601 2168 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1103 duloxetine 36.1 µM 0.10174172653348 0.458213991575521 no 1492 0.459480840494508 2194 60835 A selective serotonin reuptake inhibitor. SGTC_3107 9121808 49.47 µM 0.098992701884907 0.459360399518401 no 1493 0.460572032347264 2233 662681 SGTC_873 0591-4978 488 µM 0.098447913328528 0.45958762959376 no 1494 0.460788315048598 2225 3305145 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0984313330611601 0.45959454539318 no 1495 0.460794897647008 2093 803109 SGTC_3284 9108171 64.8615 µM 0.0975168250726979 0.45997601492253 no 1496 0.461157986716739 2136 8687505 SGTC_1828 st055811 49 µM 0.0966038827340301 0.460356868122201 no 1497 0.461520486471926 2238 5877589 SGTC_1716 st033144 30.6155 µM 0.0946536468209369 0.461170571668737 no 1498 0.462294968538508 2236 674617 SGTC_1104 tacrolimus 29.8 µM 0.0941835217106531 0.461366748013693 no 1499 0.462481687176573 2235 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_428 3448-4153 16.5 µM 0.0938293909398829 0.461514527824737 no 1500 0.46262234203944 2141 3834874 SGTC_1129 3453-1384 223 µM 0.0937067444328091 0.461565709812399 no 1501 0.462671056286386 2163 1084452 SGTC_1179 1021-1431 9.29 µM 0.0929580540795022 0.461878161837723 no 1502 0.462968442435543 2177 2840958 SGTC_1478 0453-0656 35.7 µM 0.0925825498069473 0.462034880449395 no 1503 0.463117603716929 2226 5258496 SGTC_601 0986-0029 62.9 µM 0.0919188153764938 0.462311907781323 no 1504 0.463381271119389 2184 24747981 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0916655505032296 0.462417619482232 no 1505 0.463481884417076 2120 4174840 SGTC_2056 5235370 200 µM 0.0912358843271816 0.462596966418557 no 1506 0.463652581137093 2144 5511916 SGTC_192 3455-0609 60.9 µM 0.0903168691708924 0.462980597967345 no 1507 0.464017707637859 2192 3769639 SGTC_1024 4507-0395 26 µM 0.0896471208729491 0.463260197849538 no 1508 0.464283819042524 2135 4201836 SGTC_3336 9143619 71.43 µM 0.0895309947642059 0.463308678876788 no 1509 0.464329961112355 2254 45595730 SGTC_2478 5763493 32.33 µM 0.0890495452462253 0.463509683126096 no 1510 0.464521267537677 2193 1365576 YLR208W SEC13 SGTC_481 bay k-8644 50 µM 0.0888659792736033 0.463586324023032 no 1511 0.464594210576785 2114 2303 A calcium channel antagonist. SGTC_738 1315-0003 72.4 µM 0.0888404960548003 0.463596963665769 no 1512 0.464604336858228 2243 6251474 SGTC_338 4055-0136 114 µM 0.0887773594232759 0.463623324309855 no 1513 0.464629425596881 2234 2900563 SGTC_407 eburnamonine 100 µM 0.0882310652582369 0.463851418302432 no 1514 0.464846513542574 2181 3195 SGTC_722 3534-0461 190 µM 0.0866840579814224 0.464497403876794 no 1515 0.46546132430045 2165 658262 SGTC_1927 st060202 13.8 µM 0.0855973500675205 0.464951237791928 no 1516 0.465893252534716 2266 688887 SGTC_1314 1222-0010 41.1 µM 0.0847081423030436 0.465322625103135 no 1517 0.4662467113076 2167 3526027 SGTC_713 1488-1073 324 µM 0.084576333828479 0.465377678927115 no 1518 0.46629910725405 2266 3312542 SGTC_2366 9070441 60.58 µM 0.0835392651869298 0.465810865266815 no 1519 0.466711378692637 2236 6837235 SGTC_546 peri-Naphthalide 147 µM 0.0832375295103476 0.465936908695296 no 1520 0.466831336016091 2219 223824 A penicillin ester. SGTC_469 w7 172 µM 0.0825906884867735 0.466207123773811 no 1521 0.467088502745183 2256 45115570 A P450 inhibitor. SGTC_510 ag-490 170 µM 0.0822047780110638 0.466368343656628 no 1522 0.467241937002127 2271 5328779 SGTC_2257 7960413 200 µM 0.0808923024393298 0.466916691133709 no 1523 0.467763800834105 2196 2974689 YIL048W NEO1 SGTC_1739 st037196 92.5 µM 0.0802923758411168 0.467167359239881 no 1524 0.468002360917538 2256 612214 SGTC_2289 7946404 165.07 µM 0.0799317477750801 0.467318047203827 no 1525 0.468145769765771 2208 1246120 YPR165W RHO1 SGTC_1077 5-fluorocytosine 377 nM 0.0798922273669758 0.467334561039631 no 1526 0.468161485866377 2201 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1523 st012844 44.7 µM 0.078295084640985 0.468001983292045 no 1527 0.468796663675144 2147 4274103 SGTC_2492 derrusnin 100 µM 0.0776607605686958 0.468267082974373 no 1528 0.469048954162389 2200 1715307 Part of coumarin class of compounds. SGTC_293 4049-0273 38.5 µM 0.0772754280598479 0.468428129816475 no 1529 0.469202219005969 2221 1380311 SGTC_3214 9129694 49.47 µM 0.07586262647015 0.469018643681559 no 1530 0.469764195448161 2250 17158655 SGTC_3156 9099931 49.47 µM 0.0755623124499147 0.469144175862809 no 1531 0.469883660507169 2205 18111053 SGTC_2296 7971656 126.45 µM 0.0754289870847351 0.469199907258161 no 1532 0.469936698269942 2200 666570 SGTC_3226 9131256 49.47 µM 0.0754085215201475 0.469208462131395 no 1533 0.46994483966192 2267 17178073 SGTC_951 1171-0579 82.7 µM 0.0750808285175169 0.469345444018911 no 1534 0.47007520069572 2268 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1661 st013063 9.66 µM 0.0746119444408202 0.46954145275842 no 1535 0.470261735163077 2266 721395 SGTC_1774 st048371 48.465 µM 0.0740675598873142 0.469769032400964 no 1536 0.470478313897796 2247 4242727 SGTC_1667 st014849 34.6 µM 0.073602909733548 0.469963286939641 no 1537 0.470663177894512 2263 5348460 SGTC_1944 st076371 56.9 µM 0.0732414828373208 0.470114392265445 no 1538 0.470806978240258 2141 24208455 SGTC_3197 9113331 49.47 µM 0.0723249938279355 0.470497577155222 no 1539 0.471171637290227 2246 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1849 st056239 19.2 µM 0.0722370911589668 0.470534330782594 no 1540 0.471206613893493 2122 5393181 SGTC_1610 st001799 48.1 µM 0.0718069236548168 0.470714194875566 no 1541 0.471377781383648 2176 621897 SGTC_3346 9158254 43.5805 µM 0.0712442981814943 0.470949452062535 no 1542 0.471601663057388 2203 17639500 SGTC_556 4058-0063 51.5 µM 0.0711904139410838 0.47097198384516 no 1543 0.47162310531351 2203 6615692 SGTC_280 3448-3607 3.04 µM 0.070596017783821 0.471220537713661 no 1544 0.471859639927503 2284 626179 SGTC_697 0508-1955 564 µM 0.0697301985680981 0.471582610415224 no 1545 0.472204202647139 2267 6243113 SGTC_2343 7990716 14.84 µM 0.0692626156881475 0.47177815639869 no 1546 0.472390291301919 2240 6456862 SGTC_801 0866-0028 10.1 µM 0.0692101611484405 0.471800093629185 no 1547 0.472411167538619 2286 6849771 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.068057359035546 0.47228223326382 no 1548 0.472869987087327 2284 1273210 SGTC_1425 4048-4433 7.33 µM 0.0677615112441028 0.472405973086354 no 1549 0.472987741442809 2287 23734946 SGTC_125 0133-0007 11.75 µM 0.0676606083308409 0.472448176845549 no 1550 0.473027903707772 2284 26541 SGTC_2139 5578692 56.4705 µM 0.0661099089815446 0.473096812616336 no 1551 0.473645160942701 2305 650991 YMR113W FOL3 SGTC_1769 st044406 64.4 µM 0.0659559073964679 0.473161233240168 no 1552 0.473706464887205 2160 670903 SGTC_1540 guanosine 70.6 µM 0.0658970433568026 0.473185856926512 no 1553 0.473729897263977 2276 6802 Guanosine is a purine nucleoside SGTC_2592 piperlongumine 83.33 µM 0.0646339572002075 0.473714248821855 no 1554 0.474232723645066 2204 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1009 4106-0057 9.87 µM 0.0641967875264959 0.473897142585072 no 1555 0.474406767651516 2312 2928005 SGTC_2479 5617353 43.85 µM 0.06419648111795 0.473897270775705 no 1556 0.474406889639213 2269 2731746 SGTC_1453 4237-0541 195 µM 0.0637309970900165 0.47409201614832 no 1557 0.474592211400092 2291 739892 SGTC_273 hydroxyurea 18.1 mM 0.0634894870711352 0.474193059562689 no 1558 0.474688365228782 2308 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1489 4065-0444 182 µM 0.0632646795480683 0.474287116447607 no 1559 0.474777870517953 2299 2877968 SGTC_704 1310-0270 142 µM 0.0629371524553397 0.474424152584133 no 1560 0.47490827504651 2233 5718033 SGTC_2069 5228469 200 µM 0.0627051225574766 0.474521234876132 no 1561 0.475000659106271 2230 2835210 SGTC_2719 novobiocin 32.65 µM 0.0624537453363206 0.474626413877411 no 1562 0.475100747932648 2278 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1564 D-Arginine 115 µM 0.0618988638057913 0.474858588678336 no 1563 0.475321686158198 2213 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2788 5282734 71.43 µM 0.0613999372344747 0.475067357969442 no 1564 0.47552035117336 2264 743706 SGTC_3210 9128157 49.47 µM 0.0603987066752022 0.475486330383124 no 1565 0.475919044351193 2082 17590849 SGTC_166 k072-0058 166.424 µM 0.0595311925380191 0.475849370095286 no 1566 0.476264510736682 2316 5846229 SGTC_820 1582-0060 59.9 µM 0.0593650357605319 0.475918906139503 no 1567 0.476330680672089 2245 3848840 SGTC_1245 0418-0076 17.2 µM 0.058944049725173 0.476095090636551 no 1568 0.476498336207903 2236 6790114 SGTC_2800 7887935 81.82 µM 0.0582255866489946 0.476395781351707 no 1569 0.476784470046635 2238 2961002 SGTC_1353 1498-1206 8.11 µM 0.0579663618785988 0.476504275248404 no 1570 0.476887711393178 2285 6756808 SGTC_66 0109-0187 42.4 µM 0.057577351322222 0.476667091932892 no 1571 0.477042645381942 2321 759417 SGTC_1225 1216-0074 20.6 µM 0.0574916229127181 0.476702973271611 no 1572 0.477076789510081 2233 4241466 SGTC_661 1304-0007 33.6 µM 0.0573815695868467 0.476749035999468 no 1573 0.477120622074191 2258 3117130 SGTC_484 loperamide 105 µM 0.0559347474603449 0.477354630853441 no 1574 0.477696894839656 2306 3955 An opioid-receptor agonist. SGTC_990 3985-0011 41.3 µM 0.0554886458522736 0.477541365759786 no 1575 0.47787458765604 2265 5399565 YGL099W LSG1 SGTC_2724 maprotiline 69.64 µM 0.0551280016423997 0.477692332423939 no 1576 0.478018243987518 2296 4011 A tricyclic antidepressant. SGTC_935 2996-0153 430 µM 0.0544070535394168 0.477994132869146 no 1577 0.478305429634328 2325 23738523 SGTC_1959 st077091 55.8 µM 0.0531769876096822 0.478509087247333 no 1578 0.478795445447094 2309 821356 YKL052C ASK1 SGTC_1344 1488-0097 29.1 µM 0.0530514800393823 0.478561631725084 no 1579 0.478845445145978 2265 747966 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0527053582047044 0.478706539581831 no 1580 0.478983334865894 2306 688662 SGTC_1026 k007-1105 30.6 µM 0.0526036588783139 0.478749117701514 no 1581 0.479023850822925 2315 7066794 SGTC_651 3253-0966 34.4 µM 0.0525280972990172 0.478780752974374 no 1582 0.479053953912929 2288 781462 SGTC_285 1486-1325 46 µM 0.0522349480170922 0.478903486684885 no 1583 0.479170743220935 2298 22310230 SGTC_268 camptothecin 39.6153 µM 0.0506750763993121 0.479556596289303 no 1584 0.479792218638704 2322 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_660 4031-1742 102 µM 0.050505285713212 0.479627690052896 no 1585 0.479859868696069 2296 6738706 SGTC_2870 9038528 12.99 µM 0.049067687832363 0.480229658383308 no 1586 0.480432676875423 2212 6463316 SGTC_2634 4'-methoxyflavone 100 µM 0.0488938061886961 0.480302471287136 no 1587 0.480501962452927 2262 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.048479596865997 0.480475924001989 no 1588 0.480667012330846 2177 688788 SGTC_744 1594-0068 283 µM 0.0478609001255042 0.480735013961993 no 1589 0.480913550419317 2306 668392 SGTC_2004 4023728 41.89 µM 0.0475993370601768 0.480844550473073 no 1590 0.481017780190858 2315 360084 YDR527W RBA50 SGTC_261 5-fluorouridine 15.376 µM 0.0470208402271367 0.481086816578877 no 1591 0.481248308899205 2315 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_341 1486-1430 230 µM 0.046812256904337 0.481174169975414 no 1592 0.481331430073538 2327 2054753 YPL210C SRP72 SGTC_210 3551-0445 56.827 µM 0.0467965129982848 0.481180763461959 no 1593 0.481337704107449 2286 2865180 YOR207C RET1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0466580338315544 0.481238758219303 no 1594 0.481392889022647 2264 6857784 SGTC_1945 st075991 56.6 µM 0.0457550721960569 0.481616926161193 no 1595 0.481752734236343 2192 1084980 SGTC_1905 st060207 84.5 µM 0.0457010457186206 0.481639553433084 no 1596 0.481774265159502 2233 1948547 SGTC_1058 3448-5425 97.3 µM 0.0454499716688263 0.481744708589011 no 1597 0.481874325240485 2318 7279705 SGTC_1124 fisetin 1.16336 µM 0.0453223690725597 0.481798151759471 no 1598 0.48192517890736 2200 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3263 9137018 49.47 µM 0.0452535386110595 0.481826979820434 no 1599 0.481952610143482 2272 43844957 SGTC_1256 0570-0116 285 µM 0.0444265107747475 0.48217336885841 no 1600 0.48228221498213 2284 410638 SGTC_3219 9131112 49.47 µM 0.0441721214015549 0.482279919006651 no 1601 0.482383602127128 2335 17612988 YMR079W SEC14 SGTC_2596 sinensetin 100 µM 0.0425488974489382 0.482959830478504 no 1602 0.483030566245921 2284 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2475 5812728 15.03 µM 0.0416936597213846 0.483318079568163 no 1603 0.483371454188633 2337 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1760 st045453 10.4495 µM 0.0415133451775082 0.483393612952283 no 1604 0.483443327056309 2323 3323419 YIL048W NEO1 SGTC_1603 st002045 67.8 µM 0.0410183210699939 0.483600980568276 no 1605 0.483640645025734 2340 5887985 SGTC_3037 9091026 49.47 µM 0.0404389989854225 0.48384366657962 no 1606 0.483871569485074 2328 25236398 YIL048W NEO1 SGTC_2419 paclitaxel 166.5 µM 0.03992411099151 0.484059365288397 no 1607 0.484076814316577 2280 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2047 4141938 200 µM 0.0398650207884636 0.484084119865913 no 1608 0.484100369144812 2283 3807862 SGTC_1687 st020778 55.3625 µM 0.0393274879520083 0.484309310563454 no 1609 0.484314645673782 2295 4259299 SGTC_2443 5493264 126.67 µM 0.0372734889510141 0.485169845738892 no 1610 0.485133471775813 2321 5340055 SGTC_3076 9116187 49.47 µM 0.0369048599757658 0.485324292480825 no 1611 0.485280432344236 2322 27241210 SGTC_1331 1472-0049 76.2 µM 0.0363290518111927 0.485565546754618 no 1612 0.485509992614345 2349 24051409 SGTC_3234 9132280 49.47 µM 0.0362723541755808 0.485589302430728 no 1613 0.485532596800247 2261 17612295 SGTC_1032 k061-1018 98.7 µM 0.0362283726674174 0.485607730226681 no 1614 0.485550131358638 2337 4005393 SGTC_2278 7948257 134.34 µM 0.0361648363748004 0.485634351328852 no 1615 0.485575462072586 2354 1247028 SGTC_1128 3448-9350 235 µM 0.0349149471748707 0.486158055880889 no 1616 0.486073780879209 2237 619386 SGTC_2358 9037157 4 µM 0.0337401460397444 0.4866503202569 no 1617 0.486542182637098 2312 2388925 SGTC_3135 9127742 49.47 µM 0.0329630888382249 0.486975933462886 no 1618 0.486852011237473 2267 3643468 SGTC_2110 5483698 200 µM 0.031800220075712 0.48746323089264 no 1619 0.487315685565695 2320 2848765 YHR062C RPP1 SGTC_2889 9059656 51.95 µM 0.0316412191552606 0.48752986132663 no 1620 0.487379085850582 2325 3949838 SGTC_1255 0566-0045 221 µM 0.0303852051109599 0.488056214772474 no 1621 0.487879922009853 2314 2788469 SGTC_1168 k815-0004 80.5 µM 0.0291224051442655 0.488585432942827 no 1622 0.488383483326847 2350 642433 SGTC_398 bronopol 33.3 µM 0.0289079388333445 0.488675314179159 no 1623 0.48846900699791 2306 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1617 st002906 78 µM 0.0284238699147743 0.488878185970923 no 1624 0.488662043225753 2364 5150859 SGTC_774 k060-0086 136 µM 0.0283149643417565 0.488923828359297 no 1625 0.488705472783292 2352 5911235 SGTC_2035 5154463 94.595 µM 0.0274723017829094 0.489276993581036 no 1626 0.489041515740844 2347 2769623 SGTC_2484 5809818 12.04 µM 0.0269584605156502 0.489492351858608 no 1627 0.489246432842772 2336 2870548 SGTC_943 3253-1379 105 µM 0.0262263774643089 0.489799183688073 no 1628 0.489538388470752 2351 668464 SGTC_1730 st033808 45.1 µM 0.0252704003657131 0.490199863412573 no 1629 0.489919641737459 2234 1045166 SGTC_2150 5556613 200 µM 0.0252551861004382 0.490206240265202 no 1630 0.489925709414611 2338 743190 SGTC_2612 dictamnine 15.46 µM 0.0251149174351272 0.490265032088669 no 1631 0.489981650771527 2309 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2413 inermin 26.06 µM 0.024619325631941 0.490472754762247 no 1632 0.49017930217295 2345 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2654 protoveratrine a 100 µM 0.0238749884767464 0.49078474156301 no 1633 0.490476162449619 2362 5702278 A heart drug and vasodilator. SGTC_1227 3909-8010 46.6 µM 0.0235365891297476 0.490926582562192 no 1634 0.490611126328376 2331 15982272 SGTC_2455 5377712 9.75 µM 0.0234259457188864 0.49097295929611 no 1635 0.490655254495844 2269 2243908 SGTC_2239 6685329 187.64 µM 0.0218181285405865 0.491646897285509 no 1636 0.491296516572337 2262 805680 SGTC_618 k072-0232 33.2 µM 0.0211278038455049 0.49193626350719 no 1637 0.491571852790476 2349 5872756 YGL099W LSG1 SGTC_186 3455-3465 67.277 µM 0.0202937668886505 0.492285875831196 no 1638 0.491904514033395 2383 755278 SGTC_2771 fluoxetine 41.05 µM 0.020233388233986 0.492311185640483 no 1639 0.491928596686743 2354 3386 A selective serotonin reuptake inhibitor. SGTC_1175 0741-0056 27.6 µM 0.0195228895174478 0.492609018141941 no 1640 0.49221198866364 2360 765927 SGTC_2854 9024559 71.43 µM 0.0191959152687193 0.492746083201874 no 1641 0.492342408073475 2357 3163529 SGTC_1304 1165-0502 251 µM 0.019181096986819 0.492752294930711 no 1642 0.492348318624419 2362 767425 SGTC_1657 st012939 43.4 µM 0.0164190268992534 0.493910166085392 no 1643 0.493450050262255 2368 24207257 SGTC_2360 9040895 200 µM 0.0161600965823279 0.494018713521994 no 1644 0.493553334808889 2355 4914414 SGTC_103 0844-0104 51.839 µM 0.0160891408213789 0.494048459309048 no 1645 0.493581638382213 2373 5375804 SGTC_2969 9091408 28.7 µM 0.0158864817350224 0.494133417413043 no 1646 0.493662477327843 2328 4286311 SGTC_1660 st012960 28.1 µM 0.0147371001361413 0.494615262468135 no 1647 0.494120960469666 2361 24207266 SGTC_2987 9018338 71.43 µM 0.0147254506074357 0.494620146238152 no 1648 0.494125607454963 2377 5055682 SGTC_2705 st078069 42.8 µM 0.0146322247214485 0.494659228859942 no 1649 0.494162795195893 2364 1530061 SGTC_3352 9151559 45.5865 µM 0.0137165153769258 0.495043119773406 no 1650 0.494528073660824 2371 17159339 SGTC_530 4358-1714 28 µM 0.0134144830579303 0.495169741175007 no 1651 0.494648556036201 2327 1564641 SGTC_953 1188-0045 9.7 µM 0.0132532757355972 0.495237324530247 no 1652 0.494712862736047 2369 6144426 SGTC_1491 4138-0063 26.5 µM 0.01255678638356 0.495529317076935 no 1653 0.494990698644474 2390 23883227 SGTC_2664 lyso-paf C-16 73.48 µM 0.0125068818567266 0.495550238883106 no 1654 0.495010606106945 2387 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2796 7949634 45.45 µM 0.0119091263784316 0.495800840816528 no 1655 0.495249058267464 2394 2971588 SGTC_2849 9019321 12.99 µM 0.0115798433238643 0.495938889567247 no 1656 0.495380414140095 2369 16489627 SGTC_1044 1222-0021 1.78 µM 0.011295938889461 0.496057914159325 no 1657 0.495493668213698 2336 4306703 SGTC_329 k048-0121 21.3 µM 0.0103223090154464 0.496466103052278 no 1658 0.495882067630159 2362 6832902 SGTC_1812 st052057 4.327 µM 0.00953241002697488 0.496797266534659 no 1659 0.496197176197969 2383 3645418 SGTC_1370 2001-0092 44.6 µM 0.00942037697835322 0.496844236337639 no 1660 0.496241868911049 2365 790957 SGTC_2920 7982904 15.77 µM 0.00941934024564594 0.496844670987545 no 1661 0.49624228248921 2380 6456808 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0091860506079371 0.496942477698978 no 1662 0.496335347562041 2387 2724278 An inhibitor of dopamine biosynthesis. SGTC_940 3232-1287 54.8 µM 0.00827591722796544 0.497324052941524 no 1663 0.496698424396634 2394 1585493 YIL048W NEO1 SGTC_2769 toremifene 3.73 µM 0.00816440089486344 0.497370806562924 no 1664 0.496742911473797 2381 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_146 3448-8650 53.125 µM 0.00812223962761531 0.497388482834415 no 1665 0.49675973082821 2377 2891488 YIL048W NEO1 SGTC_2332 7982454 138.89 µM 0.0074003482674563 0.49769113929658 no 1666 0.497047715133497 2384 2981748 SGTC_2989 9073649 71.4286 µM 0.00702576390256753 0.497848186147258 no 1667 0.497197148785924 2391 21367202 SGTC_171 k064-0041 9.68 µM 0.00683430246830416 0.497928457687956 no 1668 0.497273529012885 2378 53325 SGTC_1283 0922-0125 16.4 µM 0.00667753926240362 0.497994181817179 no 1669 0.497336067056455 2392 3360884 SGTC_2298 7976326 193.81 µM 0.00637358122578355 0.49812161861735 no 1670 0.497457326186451 2384 2235818 SGTC_2220 6782180 200 µM 0.00604171852580813 0.49826075488577 no 1671 0.497589717697279 2389 833803 SGTC_578 3460-0051 92 µM 0.0049423395212478 0.498721680331409 no 1672 0.498028299827907 2389 2876744 SGTC_414 piperonyl butoxide 100 µM 0.00456561361929307 0.498879626789534 no 1673 0.498178590019119 2395 5794 A potent inhibitor of cytochrome P450. SGTC_1562 morin hydrate 59.1 µM 0.00412292444551521 0.499065229294007 no 1674 0.498355195779654 2393 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2115 tiliquinol 12.7705 µM 0.00394042991670725 0.499141742275784 no 1675 0.498427999971339 2392 71208 A bioactive hydroxyquinoline. SGTC_3302 9125395 16.351 µM 0.00258164506703273 0.49971142963884 no 1676 0.498970073773829 2396 17599668 SGTC_727 3032-0951 202 µM 0.00220199641702136 0.499870602188521 no 1677 0.499121531237876 2396 3652836 SGTC_321 4534-3890 65.3 µM 0.00194991885886975 0.499976288940108 no 1678 0.499222095416801 2404 699746 SGTC_1047 2043-3044 82 µM 0.00183681052948738 0.499976288940108 no 1679 0.499267219030753 2401 669592 SGTC_1307 1187-1599 12.2 µM 0.00175399710013827 0.499941568346424 no 1680 0.499300256755847 2400 1538471 SGTC_74 000s-0487 160.283 µM 0.00130668922216031 0.499754028788909 no 1681 0.499478706570281 2399 677548 SGTC_3174 9107204 49.47 µM 0.00114536101436643 0.499686389882471 no 1682 0.49954306716495 2402 3938802 SGTC_2341 7987486 176.74 µM 0.000895405273479141 0.499581592772175 no 1683 0.499642785026048 2403 1258686 SGTC_1688 st021091 57.6 µM 0.000277506058868879 0.499322530839298 no 1684 0.499889291101471 2404 3656366 SGTC_2103 5378138 10 µM 0.000206939944630234 0.499292945134128 no 1685 0.499917442907172 2405 244142 SGTC_2588 indole-3-carbinol 100 µM -0.000271956046684247 0.499092162252385 no 1686 0.499891505235904 2406 3712 Induces cell cycle arrest. SGTC_1222 0366-0074 1.18 µM -0.000605717149298982 0.498952229044449 no 1687 0.499758353833957 2408 286520 SGTC_2242 6630449 61.2675 µM -0.000744192364869937 0.498894171743335 no 1688 0.499703110228305 2410 691249 YDR170C SEC7 SGTC_2208 7283366 200 µM -0.000864611930262958 0.498843684496871 no 1689 0.499655069787854 2407 898663 SGTC_694 1315-0438 43.2 µM -0.000976408061447159 0.498796812737981 no 1690 0.499610469603259 2409 6793154 SGTC_1913 st060213 96.1 µM -0.00110645706140876 0.498742288283832 no 1691 0.499558587586822 2411 688959 SGTC_705 1124-0212 310 µM -0.00122293097920572 0.498693455350071 no 1692 0.499512121247991 2408 9554485 SGTC_664 1222-0054 14.9 µM -0.0036233032110468 0.497687079084147 no 1693 0.498554514317201 2419 6813991 SGTC_1648 st011736 69.8 µM -0.00420356474078456 0.497443801518964 no 1694 0.498323025235176 2414 2855514 SGTC_1274 0865-0114 173 µM -0.0046165069475579 0.497270673995237 no 1695 0.498158286732662 2417 870624 SGTC_2421 5690543 90.72 µM -0.00511903661385928 0.497059987299482 no 1696 0.497957808778925 2403 3397993 SGTC_2255 7941087 197.44 µM -0.00655721211824777 0.496457033709273 no 1697 0.49738406959069 2416 935561 SGTC_2978 9011784 42.97 µM -0.00688760799480174 0.496318516673614 no 1698 0.497252263685103 2423 2994934 SGTC_2158 5657123 3.6195 µM -0.00728061464383789 0.496153750922992 no 1699 0.497095480651431 2420 2858827 SGTC_501 nsc-95397 161 µM -0.0109646106593827 0.494609292746759 no 1700 0.495625840865535 2431 262093 SGTC_794 k038-0031 316 µM -0.0111203999255018 0.494543982131677 no 1701 0.495563693729641 2421 6624242 SGTC_1901 st060216 58.6 µM -0.0118042053311929 0.494257316178109 no 1702 0.495290912767226 2424 688792 SGTC_3143 9086658 49.47 µM -0.0131179793540852 0.49370656226186 no 1703 0.494766833491074 2460 25236626 SGTC_1272 0839-0021 27 µM -0.0140277338467875 0.493325186402501 no 1704 0.494403927400925 2450 5027250 SGTC_2432 5630864 12.22 µM -0.0140706724829433 0.493307186354447 no 1705 0.494386799053982 2449 5714970 SGTC_3085 9117376 49.47 µM -0.0164987901829604 0.492289332978752 no 1706 0.493418233625755 2458 16480349 SGTC_454 lyso-paf C-16 6.67 µM -0.0166619286219769 0.492220947982408 no 1707 0.493353159750235 2448 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1703 st026983 48.3 µM -0.0169549987600546 0.492098098293919 no 1708 0.493236258196391 2435 1104023 SGTC_1349 flufenamic acid 69 µM -0.0173704409986455 0.49192395372656 no 1709 0.493070545131475 2436 3371 A non-steroidal anti-inflammatory. SGTC_918 glabranin 770.725 nM -0.0175296249453934 0.491857227601345 no 1710 0.493007049592871 2442 124049 Also referred to as licorice root. SGTC_427 1354-0053 47.3 µM -0.0178364768960101 0.491728603204917 no 1711 0.492884652514111 2549 6813657 SGTC_3074 9116018 49.47 µM -0.0186950001495817 0.491368737087387 no 1712 0.492542208430877 2436 17027303 SGTC_598 3937-0236 20.2 µM -0.0196787850720368 0.490956373847988 no 1713 0.492149807281618 2445 1379313 SGTC_3343 9148379 18.9835 µM -0.0210002958924741 0.490402464729312 no 1714 0.491622709820257 2447 1955036 SGTC_1319 1306-0155 43.7 µM -0.0211221402047713 0.490351394798927 no 1715 0.491574111752122 2451 3122360 SGTC_2177 5811945 192 µM -0.0212680854024209 0.490290223410897 no 1716 0.491515901118741 2459 5343475 SGTC_1816 st051957 91.6 µM -0.021474104521998 0.490203873062099 no 1717 0.491433730148374 2442 674121 SGTC_665 3914-0008 307 µM -0.0221171499185848 0.489934351562225 no 1718 0.491177253082745 2459 1069549 SGTC_3017 9080681 49.47 µM -0.0247262316545504 0.488840847936097 no 1719 0.490136665819852 2479 16451914 SGTC_3151 9099821 49.47 µM -0.0247761093461766 0.488819944270116 no 1720 0.490116773593941 2483 17174189 SGTC_2636 apigenin dimethyl ether 100 µM -0.0260471451922476 0.488287265568585 no 1721 0.489609867383119 2490 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1243 0416-0003 5.65 µM -0.0260946716769901 0.488267348082607 no 1722 0.489590913501416 2469 2141977 SGTC_452 diindolylmethane 8 µM -0.0264086976310931 0.4881357462503 no 1723 0.489465678432064 2475 3071 Inhibits expression of several cancer promoting factors. SGTC_185 k048-0037 25.491 µM -0.0264976001699712 0.488098489254894 no 1724 0.48943022385766 2450 6827589 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0266861799296551 0.488019460188603 no 1725 0.48935501801321 2481 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3199 9111318 49.47 µM -0.0268423964786341 0.487953994091558 no 1726 0.48929271894424 2479 8548020 SGTC_3030 9087619 49.47 µM -0.0274708717082313 0.487690620553297 no 1727 0.489042086042857 2457 25236973 SGTC_1940 st075990 51.1 µM -0.0278084442093047 0.487549157100673 no 1728 0.488907465531655 2620 1084979 SGTC_2045 5106652 78.05 µM -0.0298791855197712 0.486681425226527 no 1729 0.488081702993102 2463 673349 SGTC_1446 4239-0190 62 µM -0.0299781364208508 0.486639961983704 no 1730 0.488042244970715 2466 1340085 SGTC_2104 5389443 200 µM -0.0310626815219438 0.486185516293559 no 1731 0.487609775564608 2494 2244536 SGTC_1606 st000094 49.2 µM -0.0319259621009931 0.485823797576437 no 1732 0.487265547213527 2455 1242210 SGTC_2152 5568786 200 µM -0.0324443493990305 0.485606596389581 no 1733 0.48705884769115 2466 5399883 SGTC_525 k781-2675 26.7 µM -0.0328707803820743 0.485427927548606 no 1734 0.48688881703806 2461 3651118 YDL195W SEC31 SGTC_1852 st056254 31.4 µM -0.03336494026417 0.485220884872305 no 1735 0.486691783851728 2513 442583 SGTC_1116 jasmonic acid  1.58368 µM -0.0351762209778232 0.484462030547899 no 1736 0.485969611702317 2494 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1626 st003712 1.76 µM -0.035577862123847 0.484293766464723 no 1737 0.485809480305083 2505 24207035 SGTC_1619 st003326 88.7 µM -0.0358003671410542 0.484200551114851 no 1738 0.485720770159923 2466 2849032 SGTC_1411 3909-8223 150 µM -0.0358595885688731 0.484175741275249 no 1739 0.485697159388933 2476 X1411 SGTC_488 nitrendipine 139 µM -0.0358902446743825 0.484162898429952 no 1740 0.485684937239836 2454 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0365596288872498 0.483882475608116 no 1741 0.485418066737806 2455 756377 SGTC_509 pifithrin 175 µM -0.036683837883614 0.483830442033983 no 1742 0.485368547734957 2470 4817 A p53 inhibitor. SGTC_1875 nocodazole 6 µM -0.0371471513626456 0.483636353406431 no 1743 0.485183838300366 2469 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_672 1441-0018 53.7 µM -0.0387601460077637 0.482960677476688 no 1744 0.484540809909441 2494 251141 SGTC_2949 9072542 2.23 µM -0.0388197892573903 0.482935694123972 no 1745 0.484517033589815 2510 16457352 SGTC_778 3456-2434 196 µM -0.039328972084147 0.482722410459023 no 1746 0.484314054048436 2558 5539063 SGTC_3167 9103034 49.47 µM -0.0402608025340595 0.482332103360451 no 1747 0.483942601735785 2480 5127859 SGTC_254 nsc-64875 3.808 µM -0.0404433887782488 0.48225562714162 no 1748 0.483869819642623 2501 56993 SGTC_1991 st073000 8.92 µM -0.0408548873621292 0.482083273424603 no 1749 0.483705791032876 2567 4301969 YIL048W NEO1 SGTC_2792 7535235 81.82 µM -0.042587771509521 0.481357502398919 no 1750 0.483015071784377 2537 1281891 SGTC_1678 st019265 80.2 µM -0.0445915601154956 0.480518347650145 no 1751 0.482216435010953 2483 5367020 SGTC_337 1315-0038 354 µM -0.0451180739251512 0.480297866223806 no 1752 0.482006597591382 2507 1626437 SGTC_1267 0828-0272 9.49 µM -0.0453160565379114 0.480214961143377 no 1753 0.481927694659536 2498 745334 SGTC_611 3453-1652 23.7 µM -0.0454555202888326 0.480156561308917 no 1754 0.48187211394676 2489 1560575 SGTC_287 k060-0039 29.6 µM -0.0458286929237322 0.480000299001616 no 1755 0.481723394592595 2513 5861974 SGTC_183 3914-0051 30.55 µM -0.0469976090930019 0.479510847052759 no 1756 0.481257566546094 2505 1596232 SGTC_1152 3909-8331 15.9 µM -0.0481216792439446 0.479040202287079 no 1757 0.48080963434023 2501 16001939 SGTC_194 1486-1323 56.904 µM -0.0486022992616357 0.478838977022782 no 1758 0.480618118793349 2511 5178754 SGTC_3034 9090421 49.47 µM -0.0495077245688446 0.478459909612872 no 1759 0.480257340717251 2485 17173761 SGTC_3315 9136395 68.55 µM -0.049543449994855 0.478444953122415 no 1760 0.480243105802624 2492 16876844 SGTC_829 1635-0120 117 µM -0.0501197034993711 0.478203708142074 no 1761 0.480013499173653 2533 285054 SGTC_3264 9137442 49.47 µM -0.0504835551794234 0.478051387984853 no 1762 0.479868526879907 2515 17015726 SGTC_120 rhodamine 6G 52.259 µM -0.0505595911245779 0.478019557267377 no 1763 0.479838231614506 2510 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2731 amoxapine 43.43 µM -0.0511936373317523 0.477754133735596 no 1764 0.479585610936077 2507 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2782 7736369 71.43 µM -0.0512705705325668 0.47772192873616 no 1765 0.479554959282055 2512 2950836 YOL077C BRX1 SGTC_2940 9060638 45.86 µM -0.0519941876989496 0.477419022575316 no 1766 0.479266662347843 2537 4027022 SGTC_1371 2421-0008 32.7 µM -0.05338290686738 0.476837741393307 no 1767 0.478713412067909 2551 2827552 SGTC_877 0771-0151 33.1 µM -0.054854396151258 0.476221868626481 no 1768 0.478127231869679 2593 6166523 SGTC_1780 st038448 24.544 µM -0.0552120011861951 0.4760722061971 no 1769 0.477984783978342 2668 728868 YDL195W SEC31 SGTC_800 3448-7362 155 µM -0.055372345800864 0.476005100953303 no 1770 0.477920913440129 2499 15991913 SGTC_2883 9059145 45.46 µM -0.055535358638636 0.475936879738757 no 1771 0.477855980642148 2494 16476510 SGTC_1041 0206-0046 107 µM -0.0560158800647264 0.475735784625754 no 1772 0.477664578280834 2605 50494 SGTC_2344 7990960 76.95 µM -0.057175339322656 0.475250583962244 no 1773 0.477202761193466 2532 140813 SGTC_3297 9117502 71.43 µM -0.0579961354930349 0.474907126295626 no 1774 0.47687585338857 2495 7453720 SGTC_2248 tofa 1.1 µM -0.0588955144121499 0.474530807526987 no 1775 0.476517665416157 2504 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_790 1575-0012 79.1 µM -0.0592794023421655 0.474370187765496 no 1776 0.476364783404556 2497 378741 YLR208W SEC13 SGTC_893 0958-0369 48.9 µM -0.0596420790412201 0.474218446667686 no 1777 0.476220351886361 2648 6819948 SGTC_305 1682-2595 20.8 µM -0.061095336028828 0.4736104530375 no 1778 0.475641641761947 2557 226033 SGTC_1571 st070080 73.4 µM -0.0618309019736468 0.473302740435145 no 1779 0.47534874717209 2567 4315245 SGTC_2765 myclobutanil 7.74 µM -0.0634803400952319 0.472612781771422 no 1780 0.474692006998035 2585 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2155 5570423 76 µM -0.0639281373823482 0.472425482614643 no 1781 0.47451372385292 2532 797402 SGTC_3010 9080089 71.4286 µM -0.0642791913098299 0.472278652345253 no 1782 0.474373961056689 2523 17027233 SGTC_899 1083-0020 478 µM -0.0649743568624909 0.47198790659841 no 1783 0.474097208680045 2656 767123 SGTC_3201 9113999 49.47 µM -0.0651359121258817 0.47192033992523 no 1784 0.474032893695016 2644 16649224 SGTC_2157 5649910 96.377 µM -0.0654277033985799 0.471798307166341 no 1785 0.473916733604166 2533 2858091 SGTC_2829 7992743 58.44 µM -0.0672919721383389 0.471018696868577 no 1786 0.473174633854881 2544 16462845 SGTC_575 k072-0246 11.9 µM -0.0674707984654214 0.470943920067804 no 1787 0.47310345424246 2526 6796779 SGTC_1346 1488-2224 62.4 µM -0.0697644610951378 0.469984909454588 no 1788 0.472190567083234 2504 3722427 SGTC_1751 st044839 27.194 µM -0.070644585405942 0.469616963776577 no 1789 0.471840312504844 2517 5291326 SGTC_1515 3460-0031 42.1 µM -0.0719321629094124 0.469078724622804 no 1790 0.471327947019203 2551 2876596 SGTC_2929 9013348 24.6 µM -0.0719716423499132 0.469062222130767 no 1791 0.471312237717983 2608 2995952 SGTC_3024 9090631 49.47 µM -0.0729271177371793 0.46866284761558 no 1792 0.470932057279946 2531 25236383 SGTC_712 r015-0009 80.6 µM -0.0731832915906559 0.468555776094941 no 1793 0.47083013105551 2586 6813872 YLR060W FRS1 SGTC_1851 st056236 18.9 µM -0.0735549596690262 0.468400436159218 no 1794 0.470682255490923 2546 5393171 SGTC_3005 9076496 71.4286 µM -0.074310640049646 0.468084611837556 no 1795 0.470381605453033 2546 21368410 SGTC_2840 9008771 71.43 µM -0.0743721423256694 0.468058908843048 no 1796 0.470357137301657 2661 2992978 SGTC_1360 1598-0022 39.8 µM -0.075266582085062 0.467685120216383 no 1797 0.470001304835187 2625 761525 SGTC_3216 9129716 49.47 µM -0.0752778581751907 0.467680408091102 no 1798 0.469996819052109 2565 8056934 SGTC_2355 9061122 103.12 µM -0.0758491105567553 0.467441695401478 no 1799 0.46976957202648 2594 5302957 SGTC_787 4152-0075 138 µM -0.0759301156660701 0.467407846252137 no 1800 0.469737348588335 2574 9566539 SGTC_2203 7227154 166.4 µM -0.0762824463353882 0.467260622562366 no 1801 0.469597195471764 2550 896304 SGTC_2467 5474540 200 µM -0.0766132499619338 0.467122398165314 no 1802 0.469465608995249 2538 5413519 SGTC_561 1550-0330 72.9 µM -0.0766898881615524 0.467090375898432 no 1803 0.469435124464177 2565 6812934 SGTC_1166 k206-0078 225 µM -0.0767275247176429 0.467074650034908 no 1804 0.469420153761019 2533 5404595 SGTC_548 1436-0017 110 µM -0.0784281527213775 0.466364122447561 no 1805 0.468743739931711 2549 9677137 SGTC_1003 4049-0218 100 µM -0.0785633454168835 0.466307643094889 no 1806 0.468689971753476 2623 295161 SGTC_751 0833-0568 350 µM -0.0787351005868568 0.466235890042951 no 1807 0.468621662950319 2600 6954252 SGTC_2707 st078556 66.6 µM -0.0793372779544951 0.465984330963957 no 1808 0.468382178108306 2580 17250899 SGTC_2450 5739737 12.93 µM -0.0806523662425693 0.465435001344449 no 1809 0.467859209787064 2604 2262825 SGTC_1560 lithocholic acid 53.1 µM -0.0812004375750403 0.465206084146265 no 1810 0.467641275766216 2551 9903 A bile acid which acts as a detergent. SGTC_1883 5-benzylidenerhodanine 20 µM -0.0814460405298942 0.465103504989366 no 1811 0.467543617826974 2588 1273210 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0815536260028393 0.465058571296167 no 1812 0.46750083974005 2550 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2052 5265182 7.135 µM -0.0816978404016682 0.464998340019841 no 1813 0.467443497865095 2605 1239884 SGTC_1132 3456-3614 2.5 µM -0.0823228698414682 0.464737305186554 no 1814 0.467194984319432 2699 3125502 SGTC_3189 9110682 49.47 µM -0.0828519937007211 0.464516335838785 no 1815 0.466984613105374 2615 17122418 SGTC_86 0417-1630 471.922 µM -0.0833827074083862 0.464294713541322 no 1816 0.466773619056843 2541 3634867 SGTC_1777 st045864 34.765 µM -0.0837049809487454 0.464160139787553 no 1817 0.466645498411123 2560 4691462 SGTC_2080 5212524 12.4 µM -0.0840026865473494 0.464035828663882 no 1818 0.466527147882276 2563 260183 SGTC_1010 4112-3296 15.2 µM -0.0844095777906511 0.46386593123273 no 1819 0.466365396244634 2561 704384 SGTC_2493 resveratrol 26.09 µM -0.0845549689305068 0.46380522476125 no 1820 0.466307600192823 2537 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1330 1469-0054 61.8 µM -0.0857463601559662 0.46330780433054 no 1821 0.465834023868942 2641 7102664 SGTC_1702 st027038 51 µM -0.0866050745510474 0.462949316077777 no 1822 0.465492716075404 2622 5521182 SGTC_533 1222-0222 6.71 µM -0.0879854758941123 0.462373101898587 no 1823 0.464944109963341 2743 3982874 SGTC_402 epigallocatechin gallate 10 µM -0.0880278608027398 0.462355410616735 no 1824 0.464927266186693 2565 65064 An antioxidant. SGTC_827 3253-0474 693 µM -0.0891420879304824 0.461890363735829 no 1825 0.464484494591239 2572 5402065 SGTC_1641 st009299 47.1 µM -0.0907314906996564 0.46122708230045 no 1826 0.463852973931162 2558 4046054 SGTC_2915 7971052 15.16 µM -0.0911940013799521 0.461034089883544 no 1827 0.463669220649634 2562 5741558 SGTC_1322 1348-1070 12 µM -0.0913163778285121 0.460983027241419 no 1828 0.463620602366847 2552 6758089 SGTC_211 3455-0679 143.504 µM -0.0931313142335526 0.460225805143056 no 1829 0.462899620188247 2615 748649 SGTC_2312 7706453 155.7 µM -0.0938938332963287 0.459907712189039 no 1830 0.462596746256955 2592 976098 SGTC_3292 9120825 59.784 µM -0.0958614967573089 0.459086999435034 no 1831 0.461815287418419 2571 24824900 SGTC_1507 4075-3230 155 µM -0.0959804222420143 0.459037401147755 no 1832 0.461768060777056 2538 659771 SGTC_3108 9121785 49.47 µM -0.0959876037843758 0.459034406080927 no 1833 0.461765208923438 2527 17140271 SGTC_272 doxorubicin 8.13 µM -0.0984398936061981 0.458011814128281 no 1834 0.460791498989366 2554 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3140 9094243 49.47 µM -0.0986805089500801 0.457911493655822 no 1835 0.460695972461971 2572 19291112 SGTC_355 1311-2252 105 µM -0.0995483644286245 0.457549678406509 no 1836 0.460351444655939 2625 5338538 SGTC_255 tunicamycin 200.472 nM -0.0997870511128525 0.457450174350604 no 1837 0.460256694225609 2652 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1837 st055472 66.5 µM -0.0997914386968279 0.45744834527309 no 1838 0.460254952526305 2726 676091 SGTC_1308 1187-1617 41.4 µM -0.0998404565434044 0.457427910981115 no 1839 0.460235494409438 2562 2882570 SGTC_83 0170-0301 39.027 µM -0.100595144734314 0.457113314930794 no 1840 0.459935925548349 2573 3089716 SGTC_3059 1327-0034 3 µM -0.1014414084414 0.456760577079973 no 1841 0.459600033402917 2617 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2585 alliin 100 µM -0.103203062649798 0.456026397684823 no 1842 0.458900904625184 2688 87310 A garlic compound which reacts with lipids. SGTC_2858 9025781 8.96 µM -0.10336988831735 0.455956879882475 no 1843 0.458834704869131 2663 4894980 YPL153C RAD53 SGTC_3080 9117754 49.47 µM -0.104046125456605 0.455675099428795 no 1844 0.458566372180846 2629 9550191 SGTC_313 3474-0040 5.03 µM -0.1044094074459 0.455523733083013 no 1845 0.458422228712664 2576 1043375 YIL048W NEO1 SGTC_1800 st050079 29.0735 µM -0.1045273394178 0.455474596521654 no 1846 0.458375436696453 2627 3645560 SGTC_762 1165-0429 115 µM -0.104896878239692 0.455320631942648 no 1847 0.458228818053651 2586 5967793 SGTC_2737 bleomycin 30.5 nM -0.105551397481599 0.455047949662766 no 1848 0.457969144215758 2607 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2488 5268135 45.7 µM -0.106527080957419 0.454641505025529 no 1849 0.45758208507738 2696 1270356 YLR208W SEC13 SGTC_2021 4019055 173 µM -0.107024111962884 0.454434472923804 no 1850 0.457384925517012 2699 44827708 YER133W GLC7 SGTC_2606 farnesol 9.78 µM -0.107396511645604 0.454279362562567 no 1851 0.457237210902927 2673 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_190 3970-0790 3.722 µM -0.108396730055264 0.453862790343165 no 1852 0.456840497445654 2566 2832352 SGTC_2163 5671233 125 µM -0.108751587287417 0.453715011130776 no 1853 0.456699761862464 2632 701023 SGTC_1386 3228-0095 33.8 µM -0.110185823633853 0.453117793278375 no 1854 0.456131002457029 2687 870181 SGTC_1472 k841-0093 193 µM -0.110230543997059 0.453099173359329 no 1855 0.456113269631079 2700 X1472 SGTC_1847 st056231 15 µM -0.110658568180713 0.452920965010196 no 1856 0.455943550965618 2589 5393180 SGTC_1563 conessine 56.1 µM -0.110982702257614 0.452786017730626 no 1857 0.455815031792074 2685 441082 An anti-amoebic, histamine inhibitor. SGTC_938 3126-1755 342 µM -0.111176446423313 0.45270535850258 no 1858 0.455738214429899 2611 1777771 SGTC_352 k048-0007 5.11 µM -0.111185673034075 0.452701517344979 no 1859 0.455734556224731 2596 6811911 SGTC_2894 9048625 32.47 µM -0.11303325189138 0.451932435990988 no 1860 0.455002096470959 2670 4092861 SGTC_896 0964-0007 44.5 µM -0.113396399351969 0.451781291738506 no 1861 0.454858147100704 2578 6756758 SGTC_91 0417-1751 58.384 µM -0.11364414124261 0.451678184017562 no 1862 0.454759947173011 2580 6795624 SGTC_1699 st031318 29.054 µM -0.113830688849301 0.451600546902374 no 1863 0.454686005259247 2701 5340658 SGTC_1363 1636-0063 10.4 µM -0.114742755829685 0.451220990880225 no 1864 0.454324511732093 2613 6072185 SGTC_826 1683-5028 118 µM -0.11500975786904 0.451109886594894 no 1865 0.454218693854229 2682 722377 SGTC_2102 5377816 72.7585 µM -0.115616334107185 0.450857493709378 no 1866 0.453978308488852 2731 1379702 SGTC_2130 NSC 7 2.4545 µM -0.116472046093902 0.450501470680253 no 1867 0.453639219639651 2690 21448 SGTC_920 mycophenolic acid 780.421 nM -0.117013298463913 0.450276300609316 no 1868 0.453424757613793 2643 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_169 k015-0017 16.025 µM -0.117342476621947 0.450139364792575 no 1869 0.453294333017751 2670 1840002 SGTC_1573 oleylamine 1.06 µM -0.117647544472415 0.450012463994997 no 1870 0.453173465731401 2602 5356789 An amine of the fatty acid oleic acid. SGTC_3204 9114183 49.47 µM -0.117939815255825 0.449890891259616 no 1871 0.453057672686646 2598 17027248 SGTC_132 0417-1715 25.805 µM -0.118077704979074 0.449833536385982 no 1872 0.453003044352361 2648 6769098 SGTC_486 niguldipine 82 µM -0.118331252684548 0.449728076609728 no 1873 0.452902597645451 2589 1236 A calcium channel blocker. SGTC_1133 3473-0247 50 µM -0.119552915170695 0.449219992339807 no 1874 0.452418660177708 2695 711311 SGTC_2082 5219693 150 µM -0.119893852056262 0.449078212951843 no 1875 0.452283617347143 2612 2834649 SGTC_3152 9099253 49.47 µM -0.119914234679533 0.449069736996871 no 1876 0.452275544100477 2702 25236131 SGTC_1529 apigenin 74 µM -0.119977883975915 0.44904326908285 no 1877 0.452250333710543 2772 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3230 9131665 49.47 µM -0.120175777501506 0.448960978517386 no 1878 0.452171952724023 2599 15943720 SGTC_1406 3909-7906 11.9 µM -0.120326797695447 0.448898180884883 no 1879 0.452112138419265 2656 X1406 SGTC_842 0271-0008 11.1 µM -0.120671942866405 0.448754666479052 no 1880 0.451975441456299 2730 1221709 SGTC_2044 5102272 200 µM -0.120946678914433 0.448640433599448 no 1881 0.45186663454773 2697 592666 SGTC_71 0417-1750 47.813 µM -0.121558304071378 0.448386140437892 no 1882 0.451624418527321 2668 6811472 SGTC_1620 st003704 16.5 µM -0.122038434577702 0.448186533179768 no 1883 0.451434289679059 2640 2834414 SGTC_3259 9138485 49.47 µM -0.123264722419333 0.447676781542131 no 1884 0.450948737590594 2734 17646153 SGTC_379 3970-0972 5.9 µM -0.124307958212537 0.447243190206168 no 1885 0.450535723217237 2682 2898042 YBL034C STU1 SGTC_2462 5162487 171.77 µM -0.124811465818165 0.447033944091611 no 1886 0.450336404983281 2600 2259986 SGTC_638 3970-0837 4.09 µM -0.125181530696599 0.446880163084666 no 1887 0.450189919294486 2669 4118451 YLR208W SEC13 SGTC_1826 st055655 41.6 µM -0.125457229019181 0.446765601429781 no 1888 0.450080791870812 2677 676168 SGTC_2384 9036245 200 µM -0.125773413880634 0.446634221765501 no 1889 0.449955643636984 2696 6462766 SGTC_1916 st067606 49.2 µM -0.126678951874275 0.446257989283877 no 1890 0.449597252789458 2750 19590279 SGTC_1339 1486-1321 22.7 µM -0.126927637773627 0.446154673841253 no 1891 0.449498835885425 2653 3469382 SGTC_3289 9119912 71.43 µM -0.127141293138865 0.4460659145962 no 1892 0.449414284719817 2728 17014829 SGTC_644 1498-1197 63.3 µM -0.12738211883829 0.445965871168962 no 1893 0.449318984022621 2719 6741615 SGTC_3224 9130643 49.47 µM -0.127490386403655 0.445920895950458 no 1894 0.449276140816276 2772 17644395 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.127650119654509 0.445854542742517 no 1895 0.449212932895451 2638 688664 SGTC_2842 9000675 19.48 µM -0.12789468338335 0.445752953884673 no 1896 0.449116159269724 2709 2989072 SGTC_143 4032-1194 15.74 µM -0.128116532631972 0.445660803431566 no 1897 0.449028376359452 2592 1806963 SGTC_2201 6605497 169.863 µM -0.12965301637631 0.445022668566891 no 1898 0.448420478101323 2677 670741 SGTC_574 1315-0397 40 µM -0.130348297657461 0.444733949955865 no 1899 0.448145434992057 2632 6794277 SGTC_1007 4101-0031 70 µM -0.130605647246649 0.444627091832796 no 1900 0.448043637570661 2698 1146276 SGTC_620 0109-0052 432 µM -0.132493667777595 0.443843261037321 no 1901 0.44729691562655 2669 493037 SGTC_1464 k208-0027 110 µM -0.133562428579875 0.443399651349829 no 1902 0.446874297787527 2751 X1464 SGTC_2567 aureobasidin a 60 nM -0.133672309430399 0.443354047204966 no 1903 0.446830851245331 2894 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1254 0550-0035 264 µM -0.134130260565934 0.443163990600135 no 1904 0.446649785686604 2764 15121435 SGTC_1756 st041558 35.5 µM -0.137378152355128 0.441816444409614 no 1905 0.445365949600031 2748 3955792 SGTC_3334 9142812 21.919 µM -0.13770291526139 0.441681737452463 no 1906 0.445237607653375 2765 45283678 SGTC_2997 9067075 71.4286 µM -0.138236786439786 0.441460310072381 no 1907 0.445026641399557 2731 27209819 SGTC_3275 9138069 49.47 µM -0.139770591695371 0.440824253985219 no 1908 0.444420624798779 2731 17617007 SGTC_1051 3253-3903 78 µM -0.141954784957639 0.439918751301973 no 1909 0.443557860145277 2637 5509239 SGTC_1186 1319-0216 26 µM -0.14196379013498 0.439915018665773 no 1910 0.443554303616811 2824 4565136 SGTC_3124 9127567 49.47 µM -0.142832348377865 0.439555027367784 no 1911 0.443211294345852 2787 17592030 SGTC_3094 9117742 49.47 µM -0.143769335390608 0.439166730445865 no 1912 0.442841309041456 2648 17149698 SGTC_1092 toremifene 6.32 µM -0.144467077758178 0.43887761693101 no 1913 0.442565825922662 2641 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1878 temozolomide 1 mM -0.144486446590217 0.438869591809833 no 1914 0.442558179102643 2661 5394 DNA alkylating agent. SGTC_947 3447-0010 211 µM -0.144844695011197 0.438721162665571 no 1915 0.442416746392543 2628 748350 SGTC_2046 4110841 106 µM -0.144846325202015 0.438720487266146 no 1916 0.442416102827108 2709 44119630 YMR134W ERG29 SGTC_153 4077-0274 519.67 µM -0.145116427407688 0.438608584504199 no 1917 0.442309474192714 2702 3121976 SGTC_965 1291-5240 308 µM -0.146821119976595 0.437902447629051 no 1918 0.441636607003447 2757 2834598 SGTC_737 1950-0117 57.9 µM -0.146973815127689 0.437839206145102 no 1919 0.441576344173787 2695 5393513 SGTC_634 1611-4317 11.2 µM -0.14726909870612 0.437716913566635 no 1920 0.441459811082376 2652 2843522 SGTC_636 0kpi-0074 126 µM -0.147325486808271 0.437693560941362 no 1921 0.441437558203188 2740 616434 SGTC_2106 5357045 167.29 µM -0.148191683830443 0.43733486055644 no 1922 0.441095747348564 2778 668842 SGTC_3132 9126706 49.47 µM -0.150514076055397 0.436373390900274 no 1923 0.440179523078922 2895 850858 SGTC_2891 9063876 19.48 µM -0.15104782761518 0.436152470827091 no 1924 0.43996899385082 2734 6472478 SGTC_248 streptozotocin 5.23457 mM -0.151527026294281 0.435954147188052 no 1925 0.439779996536502 2772 5300 DNA alkylating agent. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.15211418578768 0.435711164287728 no 1926 0.439548437884726 2674 688803 SGTC_505 gw-5074 63.9 µM -0.152287171297621 0.435639582704626 no 1927 0.439480221363944 2781 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_757 1066-0008 322 µM -0.153923647782845 0.434962511689148 no 1928 0.438834969034002 2835 6842497 SGTC_3236 9132701 49.47 µM -0.154179443883855 0.43485669653541 no 1929 0.438734124892508 2723 24282524 SGTC_2611 pyromycin 23.93 µM -0.155554410899156 0.434287994162638 no 1930 0.438192131110939 2727 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1514 1189-1591 158 µM -0.157487708059134 0.433488590187668 no 1931 0.437430247280036 2885 767698 YMR146C TIF34 SGTC_1043 0916-0009 19.3 µM -0.157683323832477 0.433407719622526 no 1932 0.437353170870383 2686 3101130 SGTC_107 0358-0022 2.6945 µM -0.158114322013589 0.433229548198403 no 1933 0.437183357619324 2760 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2919 7978188 46.38 µM -0.159105898155105 0.432819689621259 no 1934 0.436792720680807 2775 2980291 SGTC_2693 st077581 40.7 µM -0.159390919777363 0.432701891993199 no 1935 0.436680446212809 2720 25238761 SGTC_2121 5257820 149.641 µM -0.159478408249994 0.432665734761727 no 1936 0.436645984159874 2805 791256 SGTC_1622 st003707 19.4 µM -0.15949637116924 0.432658311117137 no 1937 0.436638908554931 2803 10140899 SGTC_2759 disulfiram 3.38 µM -0.161997554757704 0.431624865040024 no 1938 0.435653889728592 2698 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2656 pseudo-anisatin 100 µM -0.164051213522402 0.430776677942712 no 1939 0.434845413670826 2696 6708809 A neurotoxin. SGTC_409 arachidonic acid 100 µM -0.164067474993194 0.430769963017867 no 1940 0.434839013003291 2691 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2445 5742597 35.57 µM -0.164537959103375 0.430575692498153 no 1941 0.434653833442604 2717 1774255 SGTC_588 3970-1144 52.9 µM -0.166572992076037 0.429735588460805 no 1942 0.433853022981088 2843 1888707 SGTC_2899 9053889 58.44 µM -0.166836716897536 0.429626740556076 no 1943 0.433749263822948 2715 6470052 SGTC_2880 9042983 58.44 µM -0.167343786974066 0.429417471101486 no 1944 0.433549776419787 2846 6464714 SGTC_506 n9-isopropylolomoucine 153 µM -0.16821265109218 0.429058934220827 no 1945 0.433207994313443 2745 6610355 SGTC_2116 5511452 16.8835 µM -0.168789934386063 0.428820750542373 no 1946 0.432980937961354 2827 870744 SGTC_2238 6671620 73.2395 µM -0.169910245527142 0.42835859081448 no 1947 0.432540361759548 2655 729941 SGTC_2701 st077767 14.721 µM -0.170486020003229 0.428121105892925 no 1948 0.432313963920682 2731 5721188 SGTC_2583 asiatic acid 100 µM -0.170528991411674 0.428103382875434 no 1949 0.43229706820573 2851 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1844 rapamycin 4 nM -0.170804071579598 0.427989932953771 no 1950 0.432188913733229 2688 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1391 3442-0225 151 µM -0.171061374050025 0.427883820385528 no 1951 0.432087753595141 2707 5227075 SGTC_941 3237-0776 460 µM -0.171223134656909 0.427817112333637 no 1952 0.432024158640533 2866 760008 SGTC_513 4245-1575 41.7 µM -0.172380318716396 0.427339964377751 no 1953 0.431569271978296 2835 719745 SGTC_1201 1889-3372 45.9 µM -0.173318188844008 0.426953325252903 no 1954 0.431200663708126 2747 5392199 SGTC_1792 st045773 43.6 µM -0.173391746760077 0.426923003794889 no 1955 0.431171755991701 2708 2919270 SGTC_1031 k035-0009 16 µM -0.17363610995447 0.426822277446931 no 1956 0.431075725713189 2922 5180959 SGTC_439 amiodarone 34.4 µM -0.1753251517374 0.426126186357632 no 1957 0.430412074811309 2785 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2188 6126565 140.678 µM -0.175753518273803 0.425949683624766 no 1958 0.43024379407186 2813 874518 SGTC_2690 usnic acid 100 µM -0.176517572313055 0.425634902170041 no 1959 0.429943672360553 2906 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2128 5255449 168.493 µM -0.176635625972505 0.425586269645231 no 1960 0.429897304290323 2738 736008 SGTC_1985 st071382 65.5 µM -0.178068569373786 0.424996055206898 no 1961 0.429334562758941 2725 6123237 SGTC_1495 4469-0029 237 µM -0.1780788504491 0.424991821144975 no 1962 0.429330525721159 2709 793680 SGTC_1929 genistein trimethyl ether 50.5 µM -0.17821581528846 0.424935415651883 no 1963 0.429276744870085 2805 136420 SGTC_198 3454-2873 16.191 µM -0.17980610637606 0.424280607430611 no 1964 0.428652394778551 2728 710957 SGTC_974 1326-0144 138 µM -0.180515371369535 0.423988632223149 no 1965 0.428373994003065 2740 5411856 SGTC_2135 5326629 150.42 µM -0.180844394560207 0.423853201072355 no 1966 0.428244857876971 2774 5020077 SGTC_720 r052-1644 49.9 µM -0.181083733987914 0.423754690826663 no 1967 0.428150925961887 2835 1422863 YOR257W CDC31 SGTC_2 0422-0095 29 µM -0.182038441948757 0.423361787929655 no 1968 0.427776278789556 2682 6790840 SGTC_2775 cyproheptadine 69.59 µM -0.182378298441477 0.423221940910244 no 1969 0.427642927760796 2743 2913 A selective serotonin reuptake inhibitor. SGTC_2088 5278280 127.392 µM -0.183168641857095 0.422896761159176 no 1970 0.427332849126212 2814 791502 SGTC_1946 st076057 65.1 µM -0.185699570193876 0.421855787752877 no 1971 0.426340182697171 2731 953009 SGTC_1607 st000305 50.6 µM -0.185812560441987 0.421809327421508 no 1972 0.426295877130685 2886 5457690 SGTC_1952 st077036 64.1 µM -0.187539242313036 0.421099470834213 no 1973 0.425618929271162 2705 2937007 SGTC_2178 5812956 200 µM -0.188537527132275 0.420689182554588 no 1974 0.425227650281032 2669 5403383 SGTC_1420 4'-methoxyflavone 42 µM -0.189078536553876 0.420466867319067 no 1975 0.42501563170101 2752 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2235 salicylic acid 500 µM -0.189486355142504 0.420299300522195 no 1976 0.424855824199113 2738 338 A COX inhibitor and kinase inhibitor. SGTC_2020 4017018 200 µM -0.189795230053789 0.42017239787124 no 1977 0.424734796913036 2836 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2864 9034755 47.6 µM -0.190622339668618 0.41983261705218 no 1978 0.424410743298268 2717 4930451 SGTC_2317 5986382 200 µM -0.192593983195031 0.419022897342146 no 1979 0.423638478713039 2804 877883 SGTC_315 k915-0449 187 µM -0.192833564470813 0.418924528774184 no 1980 0.423544658072467 2778 20970215 YNL149C PGA2 SGTC_1802 st050112 57.9 µM -0.192930838326678 0.418884590997963 no 1981 0.423506566618504 2716 4662563 SGTC_2568 diosmetin 100 µM -0.195001725031582 0.418034544970836 no 1982 0.422695798583314 2801 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2292 7671323 168.05 µM -0.195741669105979 0.417730909459738 no 1983 0.422406184003748 2893 937504 SGTC_2521 angolensin 13.4 µM -0.197346251503275 0.41707263894855 no 1984 0.421778293739586 2898 821428 A flavenoid. SGTC_3271 9137798 49.47 µM -0.197972160774846 0.416815926249855 no 1985 0.421533422554473 2898 6498326 SGTC_3195 9113082 49.47 µM -0.199157045244225 0.416330050643386 no 1986 0.42106994960844 2766 17018038 SGTC_966 1300-0360 30.2 µM -0.199282324272349 0.416278685985466 no 1987 0.421020952528693 2764 70588 SGTC_2497 7-hydroxyflavone 100 µM -0.19959063840635 0.416152282650422 no 1988 0.420900374969968 2941 5281894 SGTC_2282 7944268 200 µM -0.20108589590488 0.415539376802361 no 1989 0.420315705091555 2945 2970414 SGTC_2617 dihydrotanshinone i 20.83 µM -0.201629845520999 0.415316462808161 no 1990 0.420103055524859 2770 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1061 3448-9325 110 µM -0.203137760089148 0.41469865259206 no 1991 0.419513679337108 2721 723482 SGTC_901 1112-0062 60.1 µM -0.203528644286547 0.4145385371349 no 1992 0.419360929640643 2771 1908457 SGTC_3327 9140648 26.9345 µM -0.204801832858078 0.414017107417809 no 1993 0.418863477476778 2889 8029710 SGTC_1156 4092-0367 4.88 µM -0.206545065721287 0.413303418736281 no 1994 0.418182583097683 2804 1357585 SGTC_3056 9094900 49.47 µM -0.206606467733803 0.413278285637609 no 1995 0.41815860436487 2806 25236784 SGTC_771 0250-0039 27.3 µM -0.208325524161419 0.412574785319408 no 1996 0.417487401710433 2774 3005115 SGTC_532 1548-0774 215 µM -0.208573903850945 0.412473162490238 no 1997 0.417390442109723 2987 5932993 SGTC_435 c-PAF 6.7 µM -0.20985253464429 0.411950112548352 no 1998 0.416891384565699 2952 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.210333104421305 0.411753566088399 no 1999 0.41670384977163 2927 5393153 SGTC_914 3820-6779 408 µM -0.210347053532371 0.411747861423326 no 2000 0.416698406633396 2757 2893481 SGTC_1830 st055982 50.3 µM -0.21153614617973 0.41126163566296 no 2001 0.416234464864962 2771 455313 An antimicrobial agent. SGTC_2905 7799065 20.05 µM -0.211809856502769 0.41114973344963 no 2002 0.416127689304467 2940 1296806 SGTC_424 splitomicin 100 mM -0.212648007197724 0.41080711355812 no 2003 0.415800761687904 2862 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_283 0987-0079 11.7 µM -0.213431475561175 0.41048690827251 no 2004 0.415495216048737 2870 411556 SGTC_63 0099-0242 26.702 µM -0.214004686659118 0.410252673383285 no 2005 0.415271701210587 2923 3898502 YLR359W ADE13 SGTC_2814 7977482 42.97 µM -0.214149542657666 0.410193485021335 no 2006 0.415215221182192 2945 6456762 SGTC_1415 3966-0071 78.1 µM -0.214271761630257 0.410143547770747 no 2007 0.415167568798319 2788 2893185 SGTC_425 3825-7017 13.1 µM -0.215940853152011 0.409461722546434 no 2008 0.414516926027282 3040 3397440 SGTC_1394 3474-0001 65.7 µM -0.216317529274809 0.409307887837278 no 2009 0.414370123067936 2837 5017666 YIL048W NEO1 SGTC_2174 5790901 200 µM -0.216920822217194 0.409061531814072 no 2010 0.414135025077992 2879 786020 SGTC_387 norethindrone acetate 66.7 µM -0.218393198717133 0.408460434556186 no 2011 0.413561382145089 2836 541197 SGTC_1909 st060837 51.5 µM -0.218559644819476 0.408392496504781 no 2012 0.413496545753804 2850 678937 SGTC_555 4296-0685 37 µM -0.21872935463688 0.408323229142562 no 2013 0.41343044046346 2801 2908540 YHR072W ERG7 SGTC_1364 1653-0028 37.6 µM -0.219981416229111 0.407812286645449 no 2014 0.412942813956816 2856 5718652 SGTC_2225 6654152 15.4 µM -0.220166030840276 0.407736962177248 no 2015 0.412870925499566 2831 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1108 betulinic acid 729.144 nM -0.221162476117098 0.407330462240838 no 2016 0.412482962763548 2834 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_883 0850-0245 24.6 µM -0.221270242152147 0.407286505049002 no 2017 0.412441009523636 2996 6823229 YPR165W RHO1 SGTC_1443 4112-3303 14 µM -0.222298747141586 0.40686704216276 no 2018 0.412040663671402 2812 704433 SGTC_2941 9056145 11.23 µM -0.222375342528293 0.40683580796077 no 2019 0.412010852552692 2769 2119517 SGTC_976 1348-1067 47.6 µM -0.22378318858388 0.406261819752349 no 2020 0.411463005906987 2820 5310671 YGL099W LSG1 SGTC_1115 galangin 695.678 nM -0.223853703580426 0.406233075604925 no 2021 0.411435570359603 2825 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1556 plumbagin 1.48 µM -0.224321395971647 0.406042442162185 no 2022 0.411253614406976 2785 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1388 3346-4487 254 µM -0.226080450289482 0.405325643804931 no 2023 0.410569424691666 2888 3345614 SGTC_2081 5214970 32.255 µM -0.227477785379867 0.404756468787349 no 2024 0.410026120591536 2897 2063512 SGTC_2865 9030313 51.95 µM -0.227644870424666 0.404688423674947 no 2025 0.409961167046683 2783 42562754 SGTC_1390 3413-2614 145 µM -0.229057770716493 0.404113137765383 no 2026 0.409412007484673 2864 3421432 SGTC_1161 k007-0610 110 µM -0.229369929994558 0.403986064827928 no 2027 0.409290702788262 2897 5843850 SGTC_2844 9010103 25.97 µM -0.229883210745581 0.403777141947978 no 2028 0.40909126143113 2999 2480525 SGTC_616 4092-0450 108 µM -0.230850411866817 0.403383532541769 no 2029 0.408715507889317 2875 787165 SGTC_1811 st050069 61.5 µM -0.231090162642086 0.403285979369819 no 2030 0.40862237868943 2816 3877702 SGTC_3049 9092223 49.47 µM -0.232035911862556 0.402901218357296 no 2031 0.408255060618613 2922 8623917 SGTC_1892 st058411 7.36 µM -0.232303943126662 0.402792191752289 no 2032 0.408150975016568 2946 3934738 SGTC_1461 k072-0203 53.8 µM -0.233485902522165 0.402311498479835 no 2033 0.407692057618048 2776 5418714 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.233851724616716 0.402162751504405 no 2034 0.407550046118214 2932 16725076 SGTC_2518 prenyletin 46.28 µM -0.23438463464843 0.401946090235694 no 2035 0.407343193115647 2934 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2749 bexarotene 57.39 µM -0.235378119320714 0.401542257049198 no 2036 0.406957633652242 2917 82146 An retinoic acid receptor inhibitor. SGTC_2027 5150920 200 µM -0.235977228025217 0.401298781201392 no 2037 0.406725170313905 2895 786715 SGTC_2723 salbutamol 83.58 µM -0.236232921087045 0.401194880026502 no 2038 0.406625967497109 2917 9884233 β2-adrenoceptor agonist SGTC_1933 st074711 15.9 µM -0.238266167395645 0.400368917269616 no 2039 0.405837330139296 2781 17250958 SGTC_3028 9087778 49.47 µM -0.238451402181009 0.400293691686683 no 2040 0.405765501868601 2818 17217395 SGTC_2305 7443522 69.23 µM -0.240074312742793 0.39963477095534 no 2041 0.405136323705275 2834 5415886 SGTC_3232 9132874 49.47 µM -0.240959743424582 0.399275396060694 no 2042 0.404793158702776 2831 3784940 SGTC_2219 9098279 200 µM -0.241372689914043 0.399107820233509 no 2043 0.404633138686815 2850 902349 SGTC_181 1447-1644 8.07 µM -0.241532739954846 0.399042876094483 no 2044 0.404571122323146 2927 534600 SGTC_1257 0669-0121 16 µM -0.241611343678711 0.399010981773225 no 2045 0.404540665744552 2932 4307855 SGTC_245 methotrexate 289.6 µM -0.241618874764361 0.399007925988188 no 2046 0.404537747705759 2902 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2866 9034245 58.44 µM -0.241791239709489 0.398937989527478 no 2047 0.404470963620916 2915 6462273 SGTC_3089 9117425 49.47 µM -0.241891938780942 0.398897132740209 no 2048 0.404431948301754 2889 9401657 SGTC_1282 0886-0010 32.4 µM -0.243985496701901 0.39804796186253 no 2049 0.403621026249166 2993 2836211 YNL267W PIK1 SGTC_2196 6573537 42.6665 µM -0.244726671079246 0.397747448597881 no 2050 0.403334037669728 2937 2903087 SGTC_1463 k081-0032 34.1 µM -0.245281475022399 0.397522539950501 no 2051 0.403119247251751 2904 977755 SGTC_448 monastrol 171 µM -0.245878425408714 0.397280583852583 no 2052 0.402888172628713 2885 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_415 dibenzyl ketone 100 µM -0.246008584759327 0.397227832873262 no 2053 0.402837793507076 2924 7593 SGTC_1749 st037932 54.2 µM -0.247722414170893 0.396533427805377 no 2054 0.402174594151485 2975 594497 SGTC_596 1155-0152 116 µM -0.247849337472533 0.396482014363078 no 2055 0.402125489904585 2865 280313 SGTC_2827 7993847 71.43 µM -0.24814662493703 0.396361597723274 no 2056 0.402010481003211 2946 2985692 SGTC_1627 st003713 25.6 µM -0.250222713747963 0.395520951671181 no 2057 0.401207560409643 2922 16195070 YER133W GLC7 SGTC_1372 2752-0194 270 µM -0.250452195300708 0.39542806017527 no 2058 0.401118834700576 2821 823334 SGTC_2643 anethole 100 µM -0.25087276869657 0.395257832321868 no 2059 0.400956239345784 2904 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_54 0159-0055 9 µM -0.251326021574863 0.39507439976429 no 2060 0.400781029179139 3095 3319099 SGTC_2809 7964133 12.99 µM -0.253003310282795 0.394395799411365 no 2061 0.400132827583698 2898 1253665 SGTC_61 0978-8327 98.565 µM -0.253262228628256 0.394291074275642 no 2062 0.400032790984781 2889 6150059 YHR072W ERG7 SGTC_1188 1403-0014 4.57 µM -0.253825523123068 0.39406326401494 no 2063 0.399815177218165 2872 9614867 SGTC_846 0335-0850 148 µM -0.253972135470696 0.394003976287032 no 2064 0.399758542557854 2904 6819598 SGTC_1170 0310-0127 64.8 µM -0.254040825965687 0.393976199775951 no 2065 0.399732008936615 2923 774975 SGTC_1111 tnp00062 510.699 nM -0.254128830203708 0.393940614116595 no 2066 0.399698015519582 3004 676306 SGTC_2271 7849410 118.62 µM -0.254541193245833 0.393773881552651 no 2067 0.399538742084511 2836 972430 SGTC_2304 7443016 91.4 µM -0.254624334319848 0.393740267114017 no 2068 0.399506631229779 2787 939854 SGTC_1729 st035615 45.989 µM -0.255272622312287 0.393478187536872 no 2069 0.399256271921907 2970 17385451 SGTC_2077 5212015 200 µM -0.256000611395078 0.39318394519024 no 2070 0.398975182609063 2797 780900 SGTC_32 0928-0142 34.1 µM -0.256194787529238 0.393105472388062 no 2071 0.398900216651997 2899 2244242 SGTC_1662 st014054 52 µM -0.256658116765417 0.392918243738985 no 2072 0.398721353304873 2868 2838777 SGTC_316 k060-0003 58.6 µM -0.259181059974131 0.391899172803839 no 2073 0.397747771939911 3011 6152314 SGTC_1504 k297-0033 30 µM -0.260023700145729 0.391558977110554 no 2074 0.397422746074348 2826 4388117 SGTC_69 0096-0274 206.684 µM -0.263137703800067 0.390302494379286 no 2075 0.396222222101531 3156 6741392 SGTC_47 0149-0135 24.25 µM -0.263166725394782 0.39029078969619 no 2076 0.39621103818054 2852 5239155 SGTC_864 0469-0573 172 µM -0.264090247370555 0.389918376551785 no 2077 0.395855189338437 2867 689425 SGTC_2003 4023581 200 µM -0.265051583329693 0.389530822116674 no 2078 0.395484862305702 3021 16641307 SGTC_1305 1181-0477 144 µM -0.26577669961587 0.389238570283127 no 2079 0.395205594513572 3015 6252086 SGTC_2151 5563267 85.4165 µM -0.265968488718801 0.389161281816769 no 2080 0.395131738776362 2904 5310824 SGTC_1658 st012944 20 µM -0.269515954887198 0.387732493715981 no 2081 0.393766333043553 2949 24207260 SGTC_3337 9144342 33.5465 µM -0.269872964628162 0.387588787202936 no 2082 0.393628993404086 2964 17682949 SGTC_2950 9072895 21.46 µM -0.270178792761831 0.387465694978463 no 2083 0.393511353562735 3020 17332245 SGTC_1023 4482-3888 16 µM -0.270669649390268 0.387268154614666 no 2084 0.393322560989952 3086 3303168 SGTC_3173 9105693 49.47 µM -0.271103985129503 0.387093384858296 no 2085 0.393155528314717 3047 17096658 SGTC_2942 9052777 62.25 µM -0.275359005218802 0.385382448331179 no 2086 0.39152021808858 2924 6469503 SGTC_279 1273-0055 2.93 µM -0.275637788017847 0.38527042765286 no 2087 0.391413141457 2948 2847562 SGTC_1466 k213-0079 57.5 µM -0.276169499146884 0.385056801700815 no 2088 0.391208941356687 2885 3657981 SGTC_480 am 92016 50 µM -0.276296819675958 0.385005653216766 no 2089 0.391160049207031 2953 2129 K+ channel blocker. SGTC_2153 5569715 200 µM -0.276546193593099 0.38490547801569 no 2090 0.391064292517987 2899 2054701 SGTC_1259 0671-0132 43 µM -0.277133148855362 0.384669724420056 no 2091 0.390838934584324 2926 X1259 SGTC_1142 3253-1408 9.78 µM -0.277260991366812 0.384618381471014 no 2092 0.390789855081719 2920 256655 SGTC_2512 diallyl trisulfide 49.23 µM -0.277702368666017 0.384441135086169 no 2093 0.390620421079873 2909 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2561 acetosyringone 100 µM -0.277981437872743 0.384329080145529 no 2094 0.390513303918018 2872 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1202 1988-0068 29.6 µM -0.279459852850746 0.383735612136112 no 2095 0.389945971948938 2900 2850480 SGTC_2460 5552655 174.22 µM -0.284254743226143 0.381812720948346 no 2096 0.388107582916062 3031 5401989 SGTC_1681 tripelennamine 100 µM -0.285647378691037 0.381254777105922 no 2097 0.387574105846949 2898 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1354 1498-1681 81 µM -0.287442527121272 0.380535935066673 no 2098 0.38688675123959 3002 5754243 SGTC_312 4092-0653 6.84 µM -0.29055046660785 0.37929238028799 no 2099 0.38569757411922 3022 1148278 SGTC_1046 2001-0062 216 µM -0.292691270714596 0.378436522594125 no 2100 0.384879071403433 2903 739778 SGTC_1650 st011916 45.8 µM -0.294463023070751 0.377728656131911 no 2101 0.384202057408814 3050 242528 SGTC_124 0136-0217 7.121 µM -0.294492403328034 0.377716921319806 no 2102 0.384190833728806 3075 3976905 SGTC_1853 st056710 91.2 µM -0.295671351793114 0.377246129002355 no 2103 0.383740538718885 3091 269167 SGTC_2533 agelasine 13.65 µM -0.295789075950885 0.377199127936397 no 2104 0.383695583020322 3128 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3015 9080845 49.47 µM -0.295984947670474 0.377120930689885 no 2105 0.383620788333062 3061 5296973 SGTC_1303 1160-0052 261 µM -0.296424486940431 0.376945473164021 no 2106 0.383452963645733 2957 3562476 SGTC_2353 9059630 146.67 µM -0.29773895946829 0.376420907065151 no 2107 0.382951202916702 3045 4779114 SGTC_2700 st077718 96.8 µM -0.298540005690934 0.37610134564425 no 2108 0.382645523615077 2987 904970 SGTC_1074 carmofur 3.8 µM -0.298843178668283 0.37598042297214 no 2109 0.382529851840069 2944 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2272 7805186 180 µM -0.299371326342434 0.375769796650322 no 2110 0.382328368879988 3068 2956062 YPR165W RHO1 SGTC_558 k064-0027 21.3 µM -0.300873746999031 0.375170830955154 no 2111 0.381755385065052 3037 5088526 SGTC_2520 obtusaquinone 4.71 µM -0.306326368987739 0.372999586979256 no 2112 0.379678082026274 3099 5967872 SGTC_118 0083-0097 135.343 µM -0.306462533629333 0.372945417237019 no 2113 0.379626251077388 2973 5207356 SGTC_3138 9097216 49.47 µM -0.306906724256549 0.372768724426476 no 2114 0.379457185353274 2906 25237486 SGTC_2068 5226020 147 µM -0.307649805374117 0.372473197023724 no 2115 0.37917440889245 2997 1810509 SGTC_487 nimodipine 119 µM -0.307795814410514 0.372415137254808 no 2116 0.379118853348341 3004 4497 L-type voltage-gated calcium channels inhibitor SGTC_2878 9043973 25.97 µM -0.308879676305468 0.371984235681326 no 2117 0.378706528662835 3084 6465167 SGTC_53 0973-0023 39.979 µM -0.310293459385778 0.371422411160748 no 2118 0.378168902262302 2972 674768 SGTC_1819 st053448 58.6 µM -0.310513252936667 0.371335091769897 no 2119 0.378085341417736 2967 2857616 SGTC_392 N-ethylmaleimide 8.33 µM -0.310888865128683 0.371185884214633 no 2120 0.377942554833958 2997 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3147 9097027 49.47 µM -0.311640537321774 0.370887349374566 no 2121 0.377656861520788 2977 25236841 SGTC_2959 9079155 11 µM -0.31279719065983 0.370428123663074 no 2122 0.377217374946975 3115 16189457 SGTC_3331 9141060 1.957 µM -0.314239054454914 0.369855919462005 no 2123 0.376669741352596 2961 4906567 YPR165W RHO1 SGTC_157 1348-1695 65.819 µM -0.314406705020245 0.369789405938385 no 2124 0.376606082151363 2944 5380510 SGTC_1148 3909-7663 27.7 µM -0.315200115281018 0.369474681987623 no 2125 0.376304859020009 3078 4084526 SGTC_197 4544-0043 41.561 µM -0.315809120795528 0.369233165616602 no 2126 0.376073697382899 2948 896523 SGTC_1725 st036284 20.55 µM -0.315961794289067 0.369172627210351 no 2127 0.376015753716666 3191 707914 SGTC_2490 carminic acid 95.39 µM -0.316578424524379 0.368928152757627 no 2128 0.37578175453662 2929 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2671 danthron 100 µM -0.316582911703675 0.36892637392667 no 2129 0.375780051906658 3018 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_821 1114-0266 29.2 µM -0.317209047853859 0.368678185322616 no 2130 0.375542492491598 3038 3123235 SGTC_689 0833-0039 98 µM -0.31831627621373 0.368239434909978 no 2131 0.375122519642258 3004 5374726 SGTC_721 1187-1332 279 µM -0.318669877091799 0.368099353156088 no 2132 0.374988429623502 2887 25730 SGTC_2957 9076800 11.52 µM -0.319135712523375 0.367914835577206 no 2133 0.37481180187837 3001 16459615 SGTC_88 0180-0332 8.668 µM -0.319146148727973 0.367910702141741 no 2134 0.374807845152147 2938 3101745 SGTC_2385 9074692 200 µM -0.319425152380956 0.36780020369466 no 2135 0.3747020701015 2998 17046906 SGTC_477 mead ethanolamide 10 µM -0.320621088241759 0.367326681427533 no 2136 0.374248777281002 2962 16061185 SGTC_1723 st034307 2.5525 µM -0.320689678496927 0.367299529714389 no 2137 0.374222784937841 3046 867466 SGTC_964 1287-0107 19.4 µM -0.321149332253156 0.367117591156653 no 2138 0.374048613463851 3142 51516812 YPR165W RHO1 SGTC_2487 5918373 44.05 µM -0.3236038252793 0.36614656817389 no 2139 0.373118995765274 3075 2876279 SGTC_2119 5528445 120.635 µM -0.325345959062195 0.365457881255979 no 2140 0.37245962543886 3121 791935 SGTC_2486 5283202 22.39 µM -0.325629517692535 0.365345828008203 no 2141 0.372352338250682 3016 1377751 SGTC_1361 1608-0041 5.61 µM -0.326311614088617 0.365076332549503 no 2142 0.372094300979705 2994 X1361 SGTC_2434 5670830 169.91 µM -0.326311813362825 0.365076253826234 no 2143 0.372094225602598 3078 1549830 SGTC_1027 k015-0025 8.67 µM -0.326553855050069 0.36498063946554 no 2144 0.372002674964627 2952 3598955 SGTC_247 mechlorethamine 29.705 µM -0.327255847109155 0.364703377207338 no 2145 0.371737192139515 2975 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3041 9091929 49.47 µM -0.327980932279298 0.364417068258344 no 2146 0.371463039873719 3159 25236887 SGTC_2885 9057732 51.95 µM -0.329026916072779 0.364004181747562 no 2147 0.371067671800191 3133 6471414 SGTC_1447 4239-0816 81.9 µM -0.329106443090595 0.363972796092752 no 2148 0.371037617196887 2990 1341554 SGTC_2558 carylophyllene oxide 100 µM -0.32940207756962 0.363856130768673 no 2149 0.370925898832278 2954 6708694 An oxygenated terpenoid and antifungal agent. SGTC_386 1509-0011 3.07 µM -0.331219195657794 0.363139324587454 no 2150 0.370239460876915 2979 3107280 SGTC_218 alverine citrate 93.75 µM -0.332728800763712 0.362544188548226 no 2151 0.369669503608168 3119 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_679 0422-0091 41.4 µM -0.334745322735187 0.361749727275527 no 2152 0.368908604620194 2997 627384 YHR062C RPP1 SGTC_1214 0358-0031 63.7 µM -0.335117692434944 0.361603087583124 no 2153 0.368768153562876 3232 4301366 SGTC_3306 9127676 59.7925 µM -0.335718076262627 0.361366698426765 no 2154 0.368541736651963 3064 41905287 SGTC_1229 0139-0193 12.2 µM -0.33595958750819 0.361271623110595 no 2155 0.368450670731803 3149 3090752 SGTC_1459 k035-0031 35.7 µM -0.33624796517451 0.361158109194686 no 2156 0.368341942709916 2968 3877128 YMR208W ERG12 SGTC_2526 patulin 37.61 µM -0.336786083547619 0.360946322700654 no 2157 0.36813908228865 3153 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_992 3909-8734 162 µM -0.337699476143746 0.360586937669177 no 2158 0.367794834785494 3035 4288319 SGTC_292 k038-0015 474 µM -0.339088956258379 0.360040466579975 no 2159 0.367271358876207 3115 46368540 SGTC_259 usnic acid 108.925 µM -0.339463002512832 0.359893406064018 no 2160 0.367130481923813 3205 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1210 3013-0140 750 nM -0.339552812665443 0.359858099273192 no 2161 0.36709665940953 3126 905973 SGTC_511 blebbistatin 171 µM -0.339612114118384 0.359834786929674 no 2162 0.367074327040564 3144 3476986 A myosin inhibitor. SGTC_929 2805-0021 398 µM -0.339935219745053 0.359707778135606 no 2163 0.36695265640592 3081 3098024 SGTC_446 go6976 132 µM -0.340562649319094 0.359461187654302 no 2164 0.366716425860472 3133 3501 A protein kinase C inhibitor. SGTC_1775 st081588 35.1725 µM -0.342265546428324 0.35879221534231 no 2165 0.366075530737766 3024 1426443 YGL099W LSG1 SGTC_2447 5741742 33.78 µM -0.342823157643524 0.358573255308079 no 2166 0.365865751629568 3101 1776504 SGTC_117 lucigenin 22.078 µM -0.342897460744944 0.358544081839035 no 2167 0.365837801060392 3080 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2273 7815444 169.05 µM -0.343227437577959 0.358414533710263 no 2168 0.36571368240706 3179 2824616 SGTC_2427 5545055 42.75 µM -0.343436613540429 0.358332420156341 no 2169 0.365635009499332 3012 5372858 SGTC_2146 5545642 200 µM -0.343816747989753 0.358183212370115 no 2170 0.365492052080177 3075 825326 SGTC_2284 7945075 39.21 µM -0.344472145465176 0.357926011080559 no 2171 0.36524562019308 3145 1245402 SGTC_2322 7413319 38.22 µM -0.344603957962499 0.357874290950948 no 2172 0.365196064920245 3116 1840400 SGTC_1596 piperlongumine 63 µM -0.345444958749868 0.357544363445408 no 2173 0.364879941376436 3169 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_391 gliotoxin 8.33 µM -0.34547724541347 0.357531699395973 no 2174 0.364867806980811 3179 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_43 0570-0105 72.5 µM -0.346823193169949 0.357003907557849 no 2175 0.364362075878973 3008 1114046 YDL195W SEC31 SGTC_708 3448-5400 146 µM -0.347998714000744 0.356543169644778 no 2176 0.363920574643034 3119 3462195 SGTC_2575 plumbagin 510 nM -0.34839389110263 0.356388329459457 no 2177 0.36377219485056 2959 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3009 9080819 71.4286 µM -0.349221498019967 0.356064129276591 no 2178 0.363461513950074 3087 17027216 SGTC_2784 7567673 72.73 µM -0.349666622570223 0.355889802719051 no 2179 0.363294452783022 3052 3471247 SGTC_637 1181-0519 7.26 µM -0.352725291230348 0.354692736130716 no 2180 0.362147198430807 3033 6252091 YGR060W ERG25 SGTC_3128 9127691 49.47 µM -0.355710702485916 0.353525722215885 no 2181 0.361028614588433 3139 41316314 SGTC_3220 9131269 49.47 µM -0.355942147547949 0.353435306364088 no 2182 0.360941945457585 3074 17722206 SGTC_1691 st019933 84.6 µM -0.356147237561578 0.353355193232225 no 2183 0.360865151456414 3126 6176082 SGTC_1451 4152-0210 104 µM -0.358384080320279 0.352481850758845 no 2184 0.36002795180243 3186 659563 SGTC_517 1365-0151 113 µM -0.358998760976469 0.352241993624967 no 2185 0.359798008087755 3208 768657 SGTC_1941 st076221 61.8 µM -0.360032438647761 0.351838770431899 no 2186 0.35941143769841 3152 2828568 SGTC_2817 7995342 71.43 µM -0.360841774834331 0.351523175962492 no 2187 0.359108865966994 2977 18879975 SGTC_2402 5553605 200 µM -0.360907451610418 0.351497570290418 no 2188 0.359084316464176 3220 6758546 SGTC_3109 9122853 49.47 µM -0.361869303105388 0.351122646585464 no 2189 0.358724850060005 3077 1234709 SGTC_993 3909-8757 62.7 µM -0.362545224698513 0.350859263215527 no 2190 0.358472317173945 3057 4288324 YLR208W SEC13 SGTC_3316 9136639 10.545 µM -0.364658889534919 0.350036103663857 no 2191 0.357683024901401 3145 4903665 SGTC_1000 4048-0884 8.67 µM -0.366965465385878 0.349138619100555 no 2192 0.35682238912725 3169 13040088 SGTC_1810 st050138 53 µM -0.367536543325269 0.34891654370429 no 2193 0.356609419299571 3181 3444541 SGTC_1870 st057514 26.5 µM -0.367848860066937 0.348795114800357 no 2194 0.356492967159665 3019 5393161 SGTC_112 phenothiazine 287.218 µM -0.368397438807451 0.348581864610516 no 2195 0.35628845346192 3200 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2133 5320837 200 µM -0.368907420350032 0.348383661298813 no 2196 0.356098366115493 3199 2841355 SGTC_2555 cholic acid 100 µM -0.368963107029247 0.348362021287494 no 2197 0.356077611973969 3219 6708657 Influences liver metabolism. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.369684930070503 0.348081563366473 no 2198 0.355808630812255 3022 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3101 9120531 49.47 µM -0.370109380137693 0.347916685844883 no 2199 0.355650496637633 3258 24824904 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.370773995490358 0.347658573944292 no 2200 0.355402935793879 3062 165521 SGTC_1960 st011366 51.8 µM -0.370946038627442 0.347591770282959 no 2201 0.355338861828059 3027 3972846 SGTC_1809 st050081 57.6 µM -0.374274994866806 0.34630008386082 no 2202 0.354099866807416 3221 5036894 SGTC_624 k048-0052 28 µM -0.374549300268796 0.346193728560469 no 2203 0.353997842476069 3112 6835531 SGTC_3262 9137218 49.47 µM -0.374591037561418 0.346177546995376 no 2204 0.353982319750783 2988 17650664 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.374911590953629 0.346053277679517 no 2205 0.353863109226441 3098 6708561 SGTC_1195 1502-0147 41.1 µM -0.375327020723426 0.345892252189576 no 2206 0.353708636463669 3079 817940 SGTC_802 4112-3352 742 µM -0.377936660526398 0.344881363363924 no 2207 0.352738823787138 3208 704594 SGTC_403 arphamenine a 50 µM -0.378331449529078 0.34472853122333 no 2208 0.35259219263987 3069 5487158 An arginine aminopeptidase inhibitor. SGTC_3098 9119039 49.47 µM -0.378382439287189 0.344708793731534 no 2209 0.352573255799149 3079 17161528 SGTC_795 0685-0265 78 µM -0.379759665724128 0.344175846807966 no 2210 0.352061912647166 3066 302754 SGTC_2189 6047310 154.431 µM -0.380010631045706 0.344078763753512 no 2211 0.351968761829952 3051 711535 SGTC_2182 6325192 200 µM -0.38006909955552 0.344056147357252 no 2212 0.351947061344473 3169 736248 SGTC_2560 caryophyllene 100 µM -0.381464352654352 0.343516610577384 no 2213 0.351429358789963 3064 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_189 3970-0742 2.116 µM -0.381551737644284 0.343482829870495 no 2214 0.351396944129617 3181 2891807 SGTC_2034 5197015 53.07 µM -0.381552512355926 0.343482530393223 no 2215 0.351396656762274 3223 780676 SGTC_776 4476-4378 112 µM -0.381642837465093 0.343447614440023 no 2216 0.351363152637481 3147 2892008 SGTC_593 1203-0218 61.7 µM -0.381688815804088 0.34342984162797 no 2217 0.351346098421252 3212 3666956 SGTC_142 0335-0849 62.6745 µM -0.382167577679157 0.34324479799836 no 2218 0.351168534577135 3225 3889043 YPR107C YTH1 SGTC_2164 5685496 200 µM -0.382573597242192 0.343087899045041 no 2219 0.351017974954246 3210 759046 SGTC_785 1270-0111 65.3 µM -0.383279730601887 0.342815090957032 no 2220 0.350756183254477 3047 6741994 SGTC_919 tnp00227 403.569 nM -0.385078638653124 0.342120470034318 no 2221 0.350089576931986 3087 1269246 A methoxyflavone. YNL221C POP1 SGTC_2381 9035592 200 µM -0.385139294893063 0.342097057844046 no 2222 0.350067108090581 3126 4749657 SGTC_1086 cerivastatin 2.18 µM -0.385334747100515 0.342021621025487 no 2223 0.349994710460104 3166 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1230 0170-0365 3.77 µM -0.385499046104839 0.341958212988685 no 2224 0.349933856533982 3207 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1049 3226-0134 66 µM -0.385552560258242 0.341937561193951 no 2225 0.349914036513491 3148 5702385 SGTC_2016 5121758 140 µM -0.385573893000736 0.341929328748213 no 2226 0.349906135626231 3070 2795203 SGTC_134 0269-0018 6.916 µM -0.385853182790421 0.341821555914296 no 2227 0.349802702641461 3137 4378915 SGTC_1144 3486-0183 12.5 µM -0.38681170654868 0.341451777162467 no 2228 0.349447805003395 3103 6744069 SGTC_2912 7964298 10.93 µM -0.387300924386774 0.341263105601596 no 2229 0.349266720638041 3162 2975850 SGTC_3317 9138495 8.753 µM -0.389635075034055 0.340363464880596 no 2230 0.348403205925172 3097 17020139 SGTC_515 4092-1064 102 µM -0.389962307778129 0.340237413536944 no 2231 0.348282209424345 3289 717353 SGTC_2207 7258803 200 µM -0.39048011417747 0.340037988945997 no 2232 0.348090778585883 3167 3666799 SGTC_2007 4011539 71.82 µM -0.390503532598177 0.340028970784892 no 2233 0.348082121809102 3071 45595301 SGTC_2159 5658611 73.75 µM -0.391565179836511 0.33962023899308 no 2234 0.347689759970195 3210 793844 SGTC_3018 9082602 49.47 µM -0.391644150031322 0.339589843174283 no 2235 0.34766058080715 3171 17332089 SGTC_2211 7117706 200 µM -0.392093948201706 0.339416734671436 no 2236 0.347494399441562 3177 822771 SGTC_1325 1431-0015 227 µM -0.392905422131122 0.33910451801106 no 2237 0.34719466835271 3088 1103340 SGTC_835 0312-0010 67.2 µM -0.393533483841573 0.338862945486872 no 2238 0.346962749135236 3063 1626196 SGTC_1966 st070145 16.1 µM -0.394588649957169 0.338457244213842 no 2239 0.346573245633953 3032 3748532 SGTC_1473 k844-0725 134 µM -0.396274577025117 0.337809410511713 no 2240 0.345951239989993 3142 54682906 SGTC_1850 st056238 17 µM -0.396342748510245 0.33778322505087 no 2241 0.345926097542339 3130 5393177 SGTC_1967 st070177 51.4 µM -0.396744568801242 0.337628897157016 no 2242 0.3457779152863 3252 5729214 SGTC_1670 st016595 4.04 µM -0.398099058468841 0.33710887694962 no 2243 0.345278584194303 3174 597879 SGTC_3137 9097352 49.47 µM -0.398125242416231 0.337098827382984 no 2244 0.345268934161134 3384 44120435 SGTC_2591 skatole 100 µM -0.398610962709852 0.336912425912213 no 2245 0.345089941319056 3213 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1527 coumarin 137 µM -0.401342727399315 0.335864822824899 no 2246 0.344083904898786 3273 323 A hepatotoxic, DNA x-linker. SGTC_2862 9027634 71.43 µM -0.402111368873702 0.335570286202983 no 2247 0.343801033103963 3071 5012562 SGTC_2917 7979103 53.79 µM -0.403111407009144 0.335187231636097 no 2248 0.34343313467908 3242 2980565 SGTC_2165 5727197 32.143 µM -0.403574703545721 0.335009828595897 no 2249 0.343262745354027 3432 1361712 SGTC_2321 7390090 138.78 µM -0.403608727348024 0.334996801833088 no 2250 0.343250233472966 3145 649046 SGTC_2732 terfenadine 20 µM -0.409434506078458 0.332769212255345 no 2251 0.341110410608355 3148 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3179 9107801 49.47 µM -0.410272044088053 0.332449447260666 no 2252 0.340803198555152 3123 4818259 SGTC_1418 3966-3099 2.4 µM -0.410442385603001 0.33238442720744 no 2253 0.340740729564926 3216 740335 SGTC_2628 lathosterol 100 µM -0.411094737931827 0.332135468314003 no 2254 0.340501534152278 3289 6710616 SGTC_2966 9084041 48.03 µM -0.411235895576355 0.332081607704194 no 2255 0.340449784882609 3012 17741380 SGTC_140 0062-0056 502.533 µM -0.411339896825247 0.332041926839453 no 2256 0.340411659300346 3089 3758964 SGTC_2979 9012552 45.46 µM -0.411405928230816 0.332016734049572 no 2257 0.340387453843412 3233 17100905 SGTC_18 0111-0177 500 nM -0.412073374242097 0.331762127760547 no 2258 0.340142821807776 3162 721752 SGTC_1557 sumaresinolic acid 42.3 µM -0.415140197202063 0.330593246862313 no 2259 0.339019637240042 3123 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_703 3875-0075 71.8 µM -0.415282833691845 0.330538922841242 no 2260 0.338967433166496 3137 2850814 SGTC_2824 7998404 51.95 µM -0.415901825830411 0.330303217095344 no 2261 0.338740921707848 3104 837851 SGTC_1923 st058458 19.1 µM -0.416034784215972 0.330252596709487 no 2262 0.338692275063079 3331 3534982 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.418690381780331 0.329242199958968 no 2263 0.337721212943623 3243 140250 A respiratory chain inhibitor. SGTC_2387 9077560 195.08 µM -0.41869635354984 0.329239929232712 no 2264 0.33771903048362 3139 5303272 SGTC_1248 0469-0687 58.6 µM -0.418952896284224 0.329142386486382 no 2265 0.33762527879395 3222 4017482 SGTC_996 3970-0799 1.8 µM -0.421675207669113 0.328108026199331 no 2266 0.336631051512684 3186 6615648 YGL040C HEM2 SGTC_201 4262-0159 12.803 µM -0.422406868824661 0.327830250859765 no 2267 0.336364032561522 3190 1341029 SGTC_1284 0929-0043 16 µM -0.422869530407408 0.327654650412791 no 2268 0.336195227291933 3200 1239883 SGTC_2830 7992007 71.43 µM -0.423000460772471 0.327604963489945 no 2269 0.336147462438824 3032 1952075 SGTC_2101 5377231 179.231 µM -0.4265135597262 0.326272915622116 no 2270 0.334866834765903 3249 2844213 SGTC_3038 9091290 49.47 µM -0.426554432467695 0.326257431057478 no 2271 0.334851946710873 3317 25236843 SGTC_2507 purpurin 79.67 µM -0.427488241537789 0.325903740798697 no 2272 0.334511873873732 3132 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1219 1469-0211 33.1 µM -0.427590844928768 0.325864888200991 no 2273 0.334474516234614 3255 6822282 SGTC_1721 st082152 9.2685 µM -0.427727414186752 0.325813176757556 no 2274 0.334424794250527 3168 5296051 SGTC_1251 0490-5699 265 µM -0.427814985892759 0.325780019818792 no 2275 0.334392912769099 3319 3883818 SGTC_2818 7996756 12.99 µM -0.428052099416115 0.3256902493536 no 2276 0.334306594874123 3080 2241621 SGTC_495 decylubiquinone 155 µM -0.428286335792187 0.325601578091673 no 2277 0.334221332966513 3209 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2780 5215298 71.43 µM -0.428679771507842 0.325452663393376 no 2278 0.334078141840008 3283 2834131 SGTC_1177 0983-0204 23.6 µM -0.431793032698728 0.324275283814544 no 2279 0.332945921906949 3298 766818 SGTC_1422 4031-0024 15.5 µM -0.431832890279976 0.324260221744802 no 2280 0.332931436483251 3214 782427 SGTC_2545 solidagenone 89.61 µM -0.432286404137554 0.324088860369363 no 2281 0.332766633698269 3077 6708572 An anti ulcer agent SGTC_2002 4023503 131 µM -0.434991999403589 0.323067319584754 no 2282 0.331784117363882 3362 4736863 YCR052W RSC6 SGTC_2154 5570129 200 µM -0.435534788993077 0.32286254098972 no 2283 0.331587146445743 3254 673366 SGTC_1444 4112-3581 28 µM -0.435577878161234 0.322846287009845 no 2284 0.331571511970091 3188 2877249 SGTC_1633 st005664 67.9 µM -0.435594723502486 0.322839932747625 no 2285 0.331565399885518 3114 2063822 SGTC_1342 1486-1464 234 µM -0.438534369941328 0.321731856720503 no 2286 0.33049948041239 3181 3253938 SGTC_648 0375-0473 33.3 µM -0.438988629826884 0.321560768152367 no 2287 0.330334887520631 3180 1713139 SGTC_3046 9092212 49.47 µM -0.439025605530948 0.32154684360361 no 2288 0.330321491483964 3240 25236637 SGTC_59 0330-0160 1.33 µM -0.439046784704609 0.321538867926936 no 2289 0.330313818516746 3274 4293482 SGTC_1113 artemisinin 1.17947 µM -0.440132898636246 0.321129968289304 no 2290 0.329920427835828 3275 2240 An anti-malaria and mitochondrial poison. SGTC_3043 9092303 49.47 µM -0.440424343235136 0.321020282239152 no 2291 0.329814898522647 3222 25236084 SGTC_685 1278-0033 54.9 µM -0.440440954554883 0.321014030989383 no 2292 0.329808884129929 3303 3590572 SGTC_2884 9058502 51.95 µM -0.44154407038664 0.320599014882716 no 2293 0.329409582036478 3275 6471554 SGTC_3256 9138902 49.47 µM -0.443618819935692 0.319819056711203 no 2294 0.328659098374817 3205 17228773 SGTC_1033 k072-0102 21.3 µM -0.444812142850652 0.319370812546493 no 2295 0.328227759177023 3311 5965931 SGTC_476 mead acid 10 µM -0.445474716626665 0.319122045900048 no 2296 0.327988363669522 3179 5312531 An omega 9 fatty acid. SGTC_1552 6-methylflavone 10.6 µM -0.446030115651282 0.318913581283546 no 2297 0.327787746057792 3283 689013 SGTC_1329 1447-1697 50.6 µM -0.448082031962716 0.318143907855565 no 2298 0.32704699754302 3259 2840515 SGTC_2571 chrysanthemic acid 100 µM -0.449218667137343 0.31771789367255 no 2299 0.326636961350048 3203 2743 An insecticide. SGTC_3104 9120930 49.47 µM -0.450730628822297 0.317151579901356 no 2300 0.326091852219204 3285 17014836 SGTC_2388 9080168 200 µM -0.451134455728752 0.317000396614451 no 2301 0.325946322878687 3172 15943073 SGTC_2768 sulfasalazine 50.2 µM -0.451196787050622 0.316977063955561 no 2302 0.325923862556011 3359 5384001 An antioxidant and salicylic acid derivative. SGTC_849 0386-0493 241 µM -0.452489101576723 0.316493472307232 no 2303 0.325458335375834 3186 726119 SGTC_1042 0350-0096 82 µM -0.453635516081157 0.316064739711406 no 2304 0.325045593159719 3190 3122515 SGTC_1813 st051246 8.6015 µM -0.454783332923467 0.315635730340591 no 2305 0.324632561048243 3268 5291959 SGTC_1080 nisoldipine 24.4 µM -0.455001623923436 0.315554169726371 no 2306 0.324554035273101 3149 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1796 st049173 110.4 µM -0.455081339723251 0.315524387551222 no 2307 0.324525361069231 3301 94134 SGTC_726 3448-4391 34.2 µM -0.455352165756995 0.315423214699463 no 2308 0.324427951252708 3402 1356692 SGTC_3285 9112818 20.8695 µM -0.455757371293174 0.315271867353139 no 2309 0.324282230691571 3219 17017947 YPR165W RHO1 SGTC_3130 9127414 49.47 µM -0.4562251647658 0.315097181484418 no 2310 0.324114035637506 3288 1494646 SGTC_2018 5133068 143 µM -0.456511032743438 0.314990451528475 no 2311 0.324011269527351 3178 785362 SGTC_3160 9100216 49.47 µM -0.456769185539949 0.314894082418864 no 2312 0.323918478215407 3269 17191039 SGTC_764 1951-2361 146 µM -0.459780402716897 0.313770919447653 no 2313 0.322836925563245 3215 5438930 SGTC_346 4513-0042 7.16 µM -0.460627763928245 0.313455169949634 no 2314 0.322532844412968 3192 2827372 SGTC_2598 perillyl alcohol 100 µM -0.461064938415858 0.313292320442657 no 2315 0.322376007862789 3349 10819 An apoptosis inducer. SGTC_2887 9044784 58.44 µM -0.461460999057802 0.313144817456655 no 2316 0.322233948213581 3219 6465546 SGTC_2804 7954240 19.48 µM -0.461637366176151 0.313079143506152 no 2317 0.322170696933612 3312 828705 SGTC_1206 3978-0017 132 µM -0.46251195695599 0.31275355915169 no 2318 0.32185711488557 3426 3873677 SGTC_1335 1486-0900 202 µM -0.462548782346288 0.312739853347095 no 2319 0.321843914027189 3245 X1335 SGTC_2646 retinol 96.75 µM -0.464280915187801 0.312095474749778 no 2320 0.321223247780746 3309 445354 A vitamin A analog and teratogen. SGTC_29 0299-0004 12.984 µM -0.465160344507104 0.311768534012801 no 2321 0.320908317272439 3243 16871 A napthoquinone isolated from Swertia calycina. SGTC_1085 doxorubicin 7.67 µM -0.465505284642242 0.31164033793791 no 2322 0.320784826673726 3328 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1561 5-methoxyflavone 52.9 µM -0.466173212009821 0.311392169427771 no 2323 0.320545761122783 3282 94525 SGTC_2752 diclazuril 33.15 µM -0.466756193039329 0.311175632763552 no 2324 0.320337160517804 3298 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1654 st012436 41.8 µM -0.469510763672076 0.310153387146639 no 2325 0.319352296476604 3306 4323132 SGTC_1159 4092-0538 61.2 µM -0.46965000205911 0.310101753389422 no 2326 0.319302547192333 3254 717301 SGTC_60 0986-0278 202 µM -0.469661278510904 0.310097571907804 no 2327 0.319298518306393 3183 3110598 SGTC_2741 miltefosine 3.04 µM -0.4709070347159 0.309635777675714 no 2328 0.318853562110763 3221 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2954 9074818 52.69 µM -0.471923141193808 0.30925933554257 no 2329 0.318490824852956 3354 16648742 SGTC_1181 1222-0449 220 µM -0.472008911794881 0.309227568826389 no 2330 0.318460213780012 3379 658318 SGTC_1718 roemerine 11.9335 µM -0.473398204657944 0.308713217482724 no 2331 0.317964555249826 3296 235224 An aporphine alkaloid with mutagenic activity. SGTC_2440 5628896 157.78 µM -0.474403570027024 0.308341239618026 no 2332 0.317606073871863 3221 5522048 SGTC_2120 5538279 151.968 µM -0.475297440639328 0.308010679162117 no 2333 0.317287491528804 3279 2058197 SGTC_175 3793-3120 23.7 µM -0.477274062842379 0.307280261677003 no 2334 0.316583488969796 3219 5322297 SGTC_1143 3454-2408 5.08 µM -0.478810647297646 0.306712977975098 no 2335 0.316036670714304 3312 X1143 SGTC_1407 3909-7909 12.3 µM -0.481229168388115 0.305821034131297 no 2336 0.315176816173818 3291 4411780 SGTC_282 k297-0036 65.7 µM -0.481404127026092 0.305756554439039 no 2337 0.315114652040435 3348 5061378 SGTC_1233 0325-0408 14.2 µM -0.483204248531067 0.305093483162395 no 2338 0.314475359510607 3353 12874 SGTC_526 4469-0568 170 µM -0.483908878419149 0.304834108079206 no 2339 0.314225269559039 3252 2901964 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.484260019586059 0.304704889202951 no 2340 0.314100673009518 3248 442882 SGTC_1574 spiramycin 23.7 µM -0.484387031740119 0.304658155117207 no 2341 0.314055610095138 3254 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2049 5262831 67.185 µM -0.484496941582987 0.304617716394863 no 2342 0.314016617183895 3299 763417 SGTC_302 1094-0063 18.9 µM -0.484815233751328 0.30450062180379 no 2343 0.313903707817312 3226 5440289 SGTC_1045 1348-1485 165 µM -0.488368565242579 0.303194770451537 no 2344 0.312644401737938 3285 6810614 SGTC_234 nsc-17383 10.7 µM -0.488640962924005 0.303094767566046 no 2345 0.312547953538121 3394 408974 SGTC_1101 ebselen 5.29 µM -0.488677301612703 0.30308142798899 no 2346 0.312535088021898 3402 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_680 0417-1641 114 µM -0.490590006779332 0.302379663718307 no 2347 0.311858227904791 3203 2835990 SGTC_2594 a-mangostin 100 µM -0.49259717361383 0.301644026526102 no 2348 0.311148622759328 3383 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1833 st055984 71 µM -0.492952431508525 0.301513906523351 no 2349 0.311023099390197 3273 676288 SGTC_3121 9125696 49.47 µM -0.493525405088275 0.301304097218238 no 2350 0.310820696797278 3316 1235365 SGTC_2673 kobusone 100 µM -0.49366655811586 0.301252420429429 no 2351 0.310770843353664 3352 6710676 An epoxy ketone and protein crosslinker. SGTC_3238 9133470 49.47 µM -0.493790018416629 0.301207224304288 no 2352 0.310727241602751 3388 3534688 SGTC_932 2857-0803 154 µM -0.494094474197122 0.301095782734961 no 2353 0.310619730099473 3437 674898 SGTC_149 3970-0822 46.1 µM -0.494922616792952 0.300792747347126 no 2354 0.310327372575297 3400 3114250 YBL034C STU1 SGTC_2383 9036125 200 µM -0.495876131734924 0.300444006015193 no 2355 0.309990903493283 3255 79580 SGTC_3222 9128301 49.47 µM -0.496704460804002 0.300141198869294 no 2356 0.309698738140684 3247 4911358 SGTC_715 0868-0130 184 µM -0.499414920108107 0.299151319106917 no 2357 0.30874355519011 3410 2876258 SGTC_840 0245-0196 390 µM -0.499521790703331 0.299112319556388 no 2358 0.308705919761405 3424 3827528 SGTC_1911 st060208 74.3 µM -0.499710384253525 0.299043503041185 no 2359 0.308639509769907 3345 688783 SGTC_1866 st057638 64 µM -0.499907959280154 0.298971416957246 no 2360 0.308569943817691 3295 688802 SGTC_225 nsc-122657 1.016 µM -0.501464133550583 0.29840391628909 no 2361 0.308022256886578 3354 275685 SGTC_2975 9084847 53.72 µM -0.502241596531812 0.298120577338045 no 2362 0.30774879306622 3342 27211724 SGTC_545 4218-0007 221 µM -0.502329290737986 0.298088625716478 no 2363 0.30771795431776 3376 2840508 SGTC_1 0258-0098 57.368 µM -0.503194996514705 0.29777328723665 no 2364 0.307413591138183 3286 6790032 YDR047W HEM12 SGTC_2423 st077119 87.2 µM -0.503328444297773 0.297724691626636 no 2365 0.307366685609546 3328 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3022 9087993 49.47 µM -0.506719994222523 0.296490859943379 no 2366 0.306175649747743 3376 17173644 SGTC_2704 st078022 71.1 µM -0.507069646073955 0.296363791408326 no 2367 0.306052976017309 3410 54697681 SGTC_853 0419-0306 21 µM -0.508254910014692 0.29593323524804 no 2368 0.3056372935402 3277 762713 SGTC_1296 1068-0102 11.9 µM -0.509733365426729 0.295396577995123 no 2369 0.305119137172699 3343 767053 SGTC_3011 9081274 71.4286 µM -0.50984373708725 0.295356532694945 no 2370 0.305080470707748 3299 6625322 SGTC_4 0960-0234 25.671 µM -0.513123066283362 0.294167860304503 no 2371 0.303932618685696 3377 6821112 SGTC_2275 7947463 200 µM -0.515045364645767 0.293472105862296 no 2372 0.303260659988527 3390 1225414 SGTC_2735 sertaconazole 140 nM -0.515241595062015 0.293401125348933 no 2373 0.30319210304961 3383 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1956 st077085 54 µM -0.515592745182567 0.293274127098683 no 2374 0.303069439178509 3327 24208685 SGTC_2971 9092186 9.93 µM -0.516938551151748 0.292787634057826 no 2375 0.302599527552214 3260 25236400 SGTC_343 4130-2827 29.8 µM -0.516948898130891 0.29278389519837 no 2376 0.302595915989128 3332 1118244 SGTC_443 clozapine 122 µM -0.517027214772201 0.292755596361392 no 2377 0.302568580570295 3364 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2085 5307070 144.047 µM -0.518221623374333 0.292324167737916 no 2378 0.302151824806482 3277 2840351 SGTC_3115 9123671 49.47 µM -0.518454131733158 0.292240218509049 no 2379 0.302070727433861 3444 3286988 SGTC_815 1582-0027 36.9 µM -0.519272232721955 0.291944924999909 no 2380 0.301785456968177 3396 3128206 SGTC_2736 butenafine 14.65 µM -0.519464274173901 0.291875627789698 no 2381 0.301718509984443 3306 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1036 k216-0215 33.5 µM -0.519549149203781 0.29184500349556 no 2382 0.301688924087512 3388 622330 SGTC_3113 9123498 49.47 µM -0.519738792482554 0.291776582518836 no 2383 0.301622822592447 3410 8897275 SGTC_2785 7756463 72.73 µM -0.520490496517234 0.291505450448655 no 2384 0.30136087498728 3275 2201551 SGTC_3203 9113543 49.47 µM -0.523476951778821 0.290429428643868 no 2385 0.300321193041356 3409 17018012 SGTC_3171 9103192 49.47 µM -0.5236094568373 0.290381730093111 no 2386 0.300275101311195 3433 13018434 SGTC_1138 3761-0006 1.03 µM -0.524132873819718 0.290193348767413 no 2387 0.300093062594145 3404 12061087 SGTC_1336 1486-0901 104 µM -0.524477297113998 0.290069419728307 no 2388 0.299973303166677 3381 5006114 SGTC_1518 st038567 90.8 µM -0.524932921592061 0.289905516839069 no 2389 0.299814911211216 3399 77966 SGTC_2697 mebhydrolin 72.4 µM -0.526619701356276 0.289299105858727 no 2390 0.299228853925842 3448 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2281 7943571 200 µM -0.526864350291239 0.289211202110794 no 2391 0.299143895914645 3488 1244024 SGTC_384 k007-0144 5.16 µM -0.527114428975201 0.289121360402742 no 2392 0.299057063659064 3359 6824886 SGTC_2459 5811157 9.22 µM -0.528582069611272 0.288594369684075 no 2393 0.298547700674158 3403 2870684 YBR192W RIM2 SGTC_3050 9093513 49.47 µM -0.528738114749924 0.288538364650015 no 2394 0.298493566480304 3407 25236664 SGTC_246 cycloheximide 667 µM -0.528818408142161 0.288509549123926 no 2395 0.298465713344093 3307 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2411 st077133 39.94 µM -0.529117136696207 0.288402353949648 no 2396 0.298362097181521 3538 1403142 YNL221C POP1 SGTC_3066 9117245 49.47 µM -0.530201277748699 0.288013480677149 no 2397 0.297986192618499 3350 17176980 SGTC_2390 9097792 176.6 µM -0.530670305535837 0.287845320659874 no 2398 0.297823633391371 3337 4497149 SGTC_1904 st060225 78 µM -0.53127438952252 0.287628807439756 no 2399 0.297614324967175 3400 66595 SGTC_3280 9140961 49.47 µM -0.532361866668095 0.287239232624741 no 2400 0.29723769547759 3298 4901226 SGTC_810 3825-7150 143 µM -0.532714072898143 0.287113112794482 no 2401 0.29711576146679 3457 22330411 YGL099W LSG1 SGTC_3052 9092717 49.47 µM -0.533295258939196 0.286905056036356 no 2402 0.296914604529947 3440 25237534 SGTC_3276 9139060 49.47 µM -0.533536859744847 0.286818587234354 no 2403 0.296831001319688 3414 4870619 SGTC_319 1348-1596 45.5 µM -0.533638788093746 0.286782110836586 no 2404 0.296795733406059 3473 5380505 SGTC_2323 6148992 148.28 µM -0.53364263409543 0.286780734537444 no 2405 0.296794402700433 3300 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3165 9101544 49.47 µM -0.534066446031526 0.286629091801325 no 2406 0.296647781713594 3419 5002184 SGTC_460 trequinsin 123 µM -0.535876512333258 0.285981866420072 no 2407 0.296021949139401 3451 5537 A vasodilator. SGTC_2306 7482397 179.52 µM -0.538523846293934 0.285036512078224 no 2408 0.295107723324935 3455 891448 SGTC_1452 4194-0072 190 µM -0.539766943630486 0.284593120751068 no 2409 0.29467888330354 3464 1343545 SGTC_451 chloral hydrate 100 µM -0.540361880364183 0.284381033698771 no 2410 0.294473745545936 3425 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1119 parthenolide 318.541 nM -0.541320132031722 0.284039588569994 no 2411 0.294143473271876 3503 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.542996920202423 0.283442586128396 no 2412 0.293565961463394 3410 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3241 9133421 49.47 µM -0.543239128184634 0.283356400315702 no 2413 0.293482584699626 3411 17018221 SGTC_3158 9100007 49.47 µM -0.543292080400053 0.283337559795962 no 2414 0.293464358089533 3341 19297233 SGTC_1978 st071761 42 µM -0.543984280291921 0.28309132875238 no 2415 0.293226145146529 3337 5147680 SGTC_2733 amorolfine 100 µM -0.547250050243892 0.281931008299457 no 2416 0.292103477518523 3412 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2806 7952793 58.44 µM -0.548306671393908 0.281556084429997 no 2417 0.291740673654216 3428 2972490 SGTC_3178 9107506 49.47 µM -0.549108872549904 0.281271597821869 no 2418 0.291465368335159 3464 8897194 SGTC_903 1134-0042 114 µM -0.549875139085988 0.280999984455642 no 2419 0.291202508541771 3378 701009 SGTC_52 0329-0193 875 nM -0.550619728801743 0.280736176201403 no 2420 0.290947190834383 3528 3739292 SGTC_1232 0279-0259 161 µM -0.551623220739603 0.280380828457621 no 2421 0.290603261871848 3395 1560000 SGTC_1992 st073643 23.3 µM -0.551810805918647 0.280314426611898 no 2422 0.290538991505156 3418 3161292 SGTC_1289 0976-0073 69.1 µM -0.55260475762884 0.28003346607117 no 2423 0.290267041737253 3465 3391136 SGTC_3244 9134489 49.47 µM -0.554369447929942 0.279409473679671 no 2424 0.289663015354224 3424 16584271 SGTC_1672 st016598 6.51 µM -0.55515018861468 0.279133620366129 no 2425 0.28939596819045 3377 4665860 YNL267W PIK1 SGTC_804 1595-0054 20.9 µM -0.555837384604525 0.278890928115751 no 2426 0.289161013117986 3356 761523 Stimulates phospholipase C. SGTC_1710 st031758 61.5 µM -0.556728893663855 0.27857623310377 no 2427 0.288856336307321 3498 5394341 SGTC_12 0849-0099 9.267 µM -0.557050685926666 0.278462685703792 no 2428 0.288746399630405 3413 6071388 SGTC_1671 st016596 74.5 µM -0.557352521568773 0.278356200682928 no 2429 0.288643298816186 3479 2829167 SGTC_3019 9081971 49.47 µM -0.557663515118343 0.278246505594254 no 2430 0.288537087990564 3516 16451803 SGTC_2511 berberine 10.47 µM -0.558073161513969 0.2781020453897 no 2431 0.288397213257476 3408 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1375 2910-0797 186 µM -0.5592185311999 0.277698329490381 no 2432 0.288006293790463 3376 742508 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.560196326797337 0.277353906167389 no 2433 0.287672766102591 3345 6708514 SGTC_2850 9015429 58.44 µM -0.560831160803651 0.277130401135949 no 2434 0.287456320948801 3403 6457570 SGTC_2197 6588183 93.1375 µM -0.560951037281383 0.277088206303322 no 2435 0.287415457993498 3421 884136 SGTC_748 act1.228 77.9 µM -0.562350601189775 0.276595812270622 no 2436 0.286938584347542 3433 4421505 YNR035C ARC35 SGTC_674 0498-0004 451 µM -0.562755144091342 0.276453566086714 no 2437 0.286800814243053 3408 4231473 SGTC_1516 st013856 110 µM -0.565089583091587 0.275633427455329 no 2438 0.2860064167315 3440 5281404 A mutagen and neurotoxin. SGTC_336 4111-0029 111 µM -0.565296859519379 0.275560664651713 no 2439 0.285935932213755 3409 3131175 SGTC_2316 5844804 197.44 µM -0.567191355119316 0.274896054536133 no 2440 0.285292090391337 3456 776813 SGTC_1759 st043059 70 µM -0.567690867901402 0.274720951591366 no 2441 0.285122446761826 3367 669426 SGTC_686 1319-0111 510 µM -0.569023547422721 0.27425405342176 no 2442 0.284670079972709 3529 4562600 SGTC_754 3474-0146 171 µM -0.570266832778755 0.273818827683402 no 2443 0.284248366445698 3322 24762078 SGTC_2036 5160441 105 µM -0.571865764744817 0.27325960645581 no 2444 0.283706459553893 3448 134534 YIL048W NEO1 SGTC_1753 st043925 64 µM -0.572599701431196 0.27300310408072 no 2445 0.283457880960223 3456 670181 SGTC_344 k064-0035 6.43 µM -0.573029458976013 0.272852964225125 no 2446 0.283312373931855 3366 5088750 SGTC_615 k087-0205 167 µM -0.57340759419686 0.272720892995349 no 2447 0.283184374787145 3409 9642773 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.573878317948989 0.27255652771828 no 2448 0.283025073109455 3425 2374 Ca(2+)-ATPase inhibitor. SGTC_816 0325-0417 81.3 µM -0.574787822642356 0.272239090188923 no 2449 0.282717401699033 3472 68101 SGTC_2123 5259487 200 µM -0.575633437306411 0.271944116625247 no 2450 0.282431487549745 3468 2173474 SGTC_2499 avocadenofuran 51.48 µM -0.57701102775696 0.271463916031624 no 2451 0.28196600297564 3357 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_295 k015-0027 31 µM -0.57730345629805 0.271362035642956 no 2452 0.28186723962843 3457 3887424 SGTC_2962 9082311 13.18 µM -0.579874472535538 0.270467129640259 no 2453 0.280999635782674 3404 16459453 SGTC_898 1000-0849 28.3 µM -0.58003514624038 0.270411252168999 no 2454 0.280945458411995 3467 6751807 SGTC_3102 9121669 49.47 µM -0.58063632580139 0.270202231231841 no 2455 0.280742792203239 3419 41905072 SGTC_1920 st075728 45.7 µM -0.580852706753909 0.270127018664394 no 2456 0.280669864404582 3526 3400306 SGTC_1382 3002-2117 298 µM -0.581858094850917 0.269777689938944 no 2457 0.28033113441469 3544 1497314 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.581870189333681 0.269773489008572 no 2458 0.280327060811528 3520 7104 SGTC_2314 7727897 200 µM -0.58207038384173 0.2697039576655 no 2459 0.280259636463955 3416 900724 SGTC_354 2783-3500 4.88 µM -0.583244759846765 0.269296255499893 no 2460 0.279864271723736 3417 6740761 SGTC_2855 9016525 58.44 µM -0.584816944730665 0.268750932332569 no 2461 0.279335404736989 3499 43811474 SGTC_1204 4049-0315 18.3 µM -0.585090268984252 0.268656184563819 no 2462 0.279243510810757 3549 588402 SGTC_2645 abamectin 100 µM -0.586188576693059 0.268275625845417 no 2463 0.278874398672864 3488 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1728 st035614 33.7865 µM -0.586309257411899 0.268233827057189 no 2464 0.278833855559278 3425 15945546 SGTC_1121 fusaric acid 630.51 nM -0.587059236843547 0.267974138811457 no 2465 0.278581961643386 3412 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_24 0417-1663 219 µM -0.587248963230028 0.26790846412926 no 2466 0.27851825623517 3496 4329390 SGTC_1038 k292-0204 154 µM -0.587957878008282 0.267663141693989 no 2467 0.278280283077953 3450 4454212 SGTC_1277 0873-0036 22 µM -0.588334747479572 0.267532770806744 no 2468 0.278153813433089 3514 5965735 SGTC_707 0865-0008 204 µM -0.589509363013529 0.267126640226098 no 2469 0.277759816547938 3488 723043 SGTC_841 0251-0215 91.2 µM -0.591578409699999 0.266412012337163 no 2470 0.277066467497955 3491 3888614 SGTC_2063 5246145 200 µM -0.592566554444964 0.266071058695091 no 2471 0.276735633835613 3517 711240 SGTC_563 tetrahydrosecaminediol 614 µM -0.593941230322339 0.265597102563493 no 2472 0.276275710606593 3543 334274 A psychoactive constituent of the cannabis plant. SGTC_444 curcumin 90.4 µM -0.5959556817163 0.264903341112874 no 2473 0.275602416864483 3496 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3252 9135871 49.47 µM -0.596583755704673 0.264687225795479 no 2474 0.275392659670451 3537 17682838 SGTC_608 k048-0125 159 µM -0.597642674187392 0.264323063416708 no 2475 0.27503919175881 3542 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_997 3996-0078 137 µM -0.599135079936908 0.263810258083718 no 2476 0.27454140515589 3483 735687 SGTC_2170 morpholine 200 µM -0.601866498898361 0.262873031245186 no 2477 0.273631502894903 3519 121171 Reacts with secondary amines. SGTC_1640 st009078 66.4 µM -0.602163437134796 0.26277124606657 no 2478 0.273532675522733 3529 690618 SGTC_641 4092-0595 30 µM -0.602985516903055 0.262489556850168 no 2479 0.273259162050106 3543 786260 SGTC_2781 5567276 71.43 µM -0.603024044831846 0.262476358880532 no 2480 0.27324634677938 3534 2853274 SGTC_2569 tetrandrine 100 µM -0.60326487408626 0.262393869095727 no 2481 0.273166248206254 3431 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1402 3909-7673 35.9 µM -0.603643472524699 0.262264216910705 no 2482 0.273040351836339 3506 5328014 SGTC_2357 9067248 200 µM -0.603788441012953 0.262214580701683 no 2483 0.272992152686417 3506 9150235 SGTC_900 1112-0045 141 µM -0.604444247587598 0.261990097209665 no 2484 0.272774162713392 3477 56211 YIL048W NEO1 SGTC_1409 3909-8004 61.9 µM -0.605202130686298 0.261730795561315 no 2485 0.272522350139358 3501 2119279 SGTC_1676 st018489 23.4 µM -0.60636079590798 0.261334625255561 no 2486 0.272137597823681 3467 3696235 SGTC_3122 9126309 49.47 µM -0.606383725026604 0.261326788450621 no 2487 0.272129986588522 3558 17591206 SGTC_1264 0783-0040 158 µM -0.607802527138711 0.260842099597335 no 2488 0.271659226502132 3479 2855798 SGTC_1097 itavastatin 7.23 µM -0.607991419079659 0.26077760554101 no 2489 0.27159658254568 3537 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_249 wiskostatin 11.211 µM -0.608548215406477 0.260587544311864 no 2490 0.271411968965386 3540 2775510 A n-wasp and actin depolymerizer. SGTC_998 3996-0085 177 µM -0.609867819257867 0.260137385316945 no 2491 0.270974685750163 3509 715391 SGTC_866 0495-0101 262 µM -0.610710239226754 0.259850218752029 no 2492 0.270695713095815 3438 635694 SGTC_2881 9058953 51.95 µM -0.610952323096722 0.259767726761548 no 2493 0.270615572040423 3489 17122249 SGTC_2333 9017922 200 µM -0.611333237544365 0.259637954521744 no 2494 0.27048949558436 3546 3163164 SGTC_212 3807-4682 38.772 µM -0.611581194983285 0.25955349686767 no 2495 0.270407441498318 3577 3125501 YBL034C STU1 SGTC_2136 5328288 199.296 µM -0.61189908117256 0.259445241291334 no 2496 0.270302264788182 3475 262395 SGTC_3025 9087895 49.47 µM -0.611976330491363 0.259418937695982 no 2497 0.270276708952669 3540 17173641 SGTC_2026 5148700 152 µM -0.614213087536633 0.258657913908618 no 2498 0.269537263051303 3508 79838 SGTC_1471 k673-0312 37 µM -0.615191583585239 0.258325358748062 no 2499 0.269214102678601 3534 24099884 SGTC_467 ro 31-8220 72.8 µM -0.615279448149901 0.258295507628282 no 2500 0.269185093836382 3472 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2134 5324836 1.464 µM -0.615280617222235 0.258295110459531 no 2501 0.269184707872983 3458 699272 SGTC_3045 9092950 49.47 µM -0.61605498870682 0.258032102917346 no 2502 0.268929114002283 3581 44120432 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.616264747205124 0.257960884453181 no 2503 0.268859900785726 3582 23847180 SGTC_2251 lansoprazole 556 µM -0.618016579713233 0.257366490216541 no 2504 0.268282204799501 3421 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1207 2099-0101 141 µM -0.619406525728863 0.256895390414643 no 2505 0.267824291615267 3531 5837381 SGTC_1886 st057356 49.9 µM -0.62016713223086 0.256637785187901 no 2506 0.267573879069912 3486 24207747 SGTC_340 k038-0059 454 µM -0.620264548710583 0.256604801508477 no 2507 0.267541815419107 3534 23733424 SGTC_1421 4029-0249 71.4 µM -0.621701547723084 0.256118512966392 no 2508 0.267069066869411 3629 2894095 SGTC_819 1013-0258 27.7 µM -0.622252383682871 0.255932234488494 no 2509 0.266887962980715 3554 5753198 SGTC_681 1642-0006 26.6 µM -0.62463257198143 0.255128129817993 no 2510 0.266106118426128 3568 4446530 SGTC_2269 7935389 174.42 µM -0.624899494328623 0.255038037274991 no 2511 0.266018512123031 3538 97605 SGTC_1995 st072814 61.1 µM -0.625594975552418 0.254803374275502 no 2512 0.26579031760456 3475 5769371 SGTC_3175 9106517 49.47 µM -0.626001921135677 0.254666118804715 no 2513 0.265656840616612 3540 41468073 SGTC_1989 st071868 50.2 µM -0.626231108857223 0.254588834930537 no 2514 0.265581682664075 3553 16414057 SGTC_1906 st060206 94.7 µM -0.626388262424843 0.254535848631748 no 2515 0.265530153238237 3545 5133468 SGTC_1338 1486-1223 76 µM -0.627213414954956 0.254257732927526 no 2516 0.265259675429194 3539 3444526 SGTC_3141 9094609 49.47 µM -0.627432903973814 0.254183781509879 no 2517 0.265187752400903 3482 25236309 YDL196W YDL196W SGTC_2367 9070478 135.38 µM -0.627582431138457 0.254133408475795 no 2518 0.265138760420992 3541 572802 SGTC_907 3448-6986 75.5 µM -0.628005395753472 0.25399094760038 no 2519 0.265000202646014 3609 590582 SGTC_2386 9075165 157.42 µM -0.628344468159101 0.253876773156763 no 2520 0.264889153455401 3520 16452277 SGTC_2216 7189485 200 µM -0.628729247284829 0.253747240716694 no 2521 0.264763163568308 3565 731273 SGTC_2438 5259590 200 µM -0.629108302873607 0.253619668993258 no 2522 0.264639077562933 3534 1201127 SGTC_2727 riluzole 51.77 µM -0.630335218080285 0.253206979956031 no 2523 0.264237642807861 3547 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2604 4'-hydroxychalcone 11.32 µM -0.630742319096001 0.253070124252751 no 2524 0.264104511856064 3586 5282362 SGTC_1158 4092-0494 91.8 µM -0.63122213584542 0.252908873576075 no 2525 0.263947645150703 3613 1148199 SGTC_2260 7964312 200 µM -0.631619081924622 0.252775513899203 no 2526 0.263817907294871 3610 231951 SGTC_1428 4049-0204 61.7 µM -0.631887487273276 0.252685360293957 no 2527 0.263730200121407 3592 X1428 SGTC_1437 4092-1038 11.6 µM -0.632559545512945 0.252459699628418 no 2528 0.263510656010956 3564 3977136 SGTC_92 0063-0024 660.874 µM -0.632708892171025 0.252409567111697 no 2529 0.263461880975824 3619 3594437 SGTC_2734 clemastine 41.6 µM -0.633732891401811 0.252065973583331 no 2530 0.263127577849198 3525 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3036 9090181 49.47 µM -0.63405119266026 0.251959220815777 no 2531 0.263023706802755 3586 25236586 SGTC_1961 st076550 68.7 µM -0.634451749900757 0.251824914718509 no 2532 0.262893023001148 3555 1579337 SGTC_3325 9138760 55.175 µM -0.634676746060523 0.251749490505573 no 2533 0.262819631443728 3531 43844959 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.634736682092356 0.251729400494762 no 2534 0.262800082661045 3653 688664 SGTC_888 0916-0002 6.97 µM -0.637115480070179 0.250932733202427 no 2535 0.262024812995931 3620 2802138 YIL048W NEO1 SGTC_1652 st011932 78 µM -0.639991400726289 0.249971362613518 no 2536 0.261089094999936 3556 1551076 SGTC_1993 st073995 70.8 µM -0.640460010216913 0.249814899953096 no 2537 0.260936789744956 3580 3098394 SGTC_1602 st001878 87.6 µM -0.642102731787542 0.249266827278419 no 2538 0.2604032411563 3613 595405 YLR310C CDC25 SGTC_453 enantio-paf c16 10 µM -0.642338687357526 0.249188156318782 no 2539 0.26032665002658 3590 13871343 A lipid and platelet activating factor SGTC_2895 9054447 58.44 µM -0.642728110292757 0.249058346032566 no 2540 0.260200268809845 3592 2697450 SGTC_2750 bromebric acid 70.15 µM -0.642751001293838 0.249050716663324 no 2541 0.260192840872073 3595 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1771 st048882 4.1505 µM -0.644375298381733 0.248509670325628 no 2542 0.25966604924365 3504 4580403 SGTC_2718 lomofungin 53.02 µM -0.646280635604927 0.247875809810268 no 2543 0.259048813162634 3616 5351222 A RNA synthesis inhibitor. SGTC_366 0181-0206 4.31 µM -0.646637367235974 0.247757229639999 no 2544 0.258933333941661 3613 274874 SGTC_2000 st075254 36.4 µM -0.648887622948558 0.247009927049324 no 2545 0.258205507687321 3573 17234175 SGTC_2833 9001315 45.46 µM -0.649359939012034 0.246853225698827 no 2546 0.2580528758076 3547 2989378 SGTC_1887 st057648 70.8 µM -0.64957834468407 0.246780782759421 no 2547 0.257982312478131 3594 688672 SGTC_1629 st005085 44.9 µM -0.650645706532508 0.246426913484541 no 2548 0.257637609215981 3589 24207091 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.65158498214058 0.246115734538789 no 2549 0.257334469199834 3625 551469 SGTC_45 0kpi-0036 14.9 µM -0.653375585262887 0.245523097904367 no 2550 0.25675708730424 3585 2795021 SGTC_165 k038-0023 64.381 µM -0.654082599237316 0.245289308494846 no 2551 0.256529295738985 3586 46368543 SGTC_1711 st032263 62.8 µM -0.654129712728541 0.245273733657616 no 2552 0.256514120069813 3592 3958979 SGTC_1506 4226-2149 212 µM -0.654340687576131 0.245203995848193 no 2553 0.256446168955613 3619 991114 SGTC_583 1488-1091 88.9 µM -0.65515505535779 0.244934906327479 no 2554 0.25618396408487 3672 4303273 SGTC_1130 3454-2858 15.9 µM -0.65552907496414 0.244811373227544 no 2555 0.2560635865327 3558 715628 YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM -0.656026142902292 0.244647251012591 no 2556 0.255903651763761 3589 3124987 SGTC_1401 3807-4679 7.6 µM -0.657501580250787 0.244160439305877 no 2557 0.25542922760913 3600 3291456 SGTC_749 1000-0129 128 µM -0.658900799167284 0.243699258403637 no 2558 0.254979736326332 3658 708470 SGTC_2319 6033012 152.6 µM -0.658917941429314 0.243693611252001 no 2559 0.254974232037556 3562 847246 SGTC_133 0724-0033 378.92 µM -0.660000383792054 0.243337166887921 no 2560 0.254626791526373 3521 280309 SGTC_2837 9008476 45.46 µM -0.660312280839743 0.243234512629697 no 2561 0.254526725380009 3626 2992805 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.660381509269457 0.243211730744296 no 2562 0.254504517569138 3638 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1474 0330-0125 5.35 µM -0.66053894301373 0.243159926301908 no 2563 0.254454018125986 3615 X1474 SGTC_570 0987-0065 62.6 µM -0.66081879203691 0.243067855166603 no 2564 0.254364264947935 3507 3104428 SGTC_2334 9017922 200 µM -0.661066672707794 0.242986317460369 no 2565 0.254284778520564 3620 3163164 SGTC_1525 8-methoxypsoralen 92.5 µM -0.661371450834936 0.242886084225045 no 2566 0.254187064974337 3649 4114 Related to psoralen; DNA damaging agent. SGTC_356 1634-0012 32.5 µM -0.661431968040194 0.242866184424918 no 2567 0.254167665168354 3616 735457 SGTC_1975 st070967 30.8 µM -0.662053496801604 0.242661858934476 no 2568 0.2539684686388 3625 261391 SGTC_773 4358-1457 44.6 µM -0.662482121862635 0.242521004127839 no 2569 0.253831144420067 3637 1186886 SGTC_719 2810-4230 27.3 µM -0.663126772081465 0.242309242524779 no 2570 0.253624682815062 3599 721079 SGTC_1109 tnp00067 928.257 nM -0.664432970620152 0.241880475835557 no 2571 0.25320661824813 3591 676295 SGTC_1704 st028805 70.8 µM -0.664519525825476 0.241852078173704 no 2572 0.253178928020811 3604 2876101 SGTC_1146 3579-1023 7 µM -0.665180799128419 0.241635182530292 no 2573 0.252967429964028 3643 X1146 SGTC_1666 st014829 29 µM -0.665461079849226 0.241543283177063 no 2574 0.252877814565486 3638 3858230 SGTC_3311 9131146 2.8755 µM -0.665978774797589 0.241373589592066 no 2575 0.252712333609972 3604 4900406 YPR165W RHO1 SGTC_2539 epi(13)torulosol 80 µM -0.666737917756666 0.24112486969788 no 2576 0.252469777068925 3604 6708597 SGTC_1964 st076914 61 µM -0.666979556978242 0.241045730082424 no 2577 0.252392595786539 3638 24208661 SGTC_560 2332-1943 155 µM -0.667540470022406 0.240862079087113 no 2578 0.252213484130392 3620 21177716 SGTC_2904 7225135 42.03 µM -0.668100507165039 0.240678790844361 no 2579 0.252034719064144 3692 4446116 SGTC_2218 6965428 192.983 µM -0.668152867024834 0.240661658457616 no 2580 0.2520180091017 3596 675684 SGTC_2675 theaflavin digallate 100 µM -0.668352335728113 0.240596397463072 no 2581 0.251954356637158 3614 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.671784955558586 0.239474844042787 no 2582 0.250860303832942 3649 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3258 9138477 49.47 µM -0.672086581736213 0.239376429163239 no 2583 0.250764289156985 3668 4970355 SGTC_2079 5212404 121 µM -0.672094930453671 0.239373705449887 no 2584 0.250761631841482 3637 758462 SGTC_2681 menadione 3.18 µM -0.673323845760302 0.238972964717066 no 2585 0.250370642747609 3644 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2537 larixol 68.93 µM -0.674589746169769 0.238560547239772 no 2586 0.249968224693827 3638 6708759 SGTC_2495 cafestol 54.53 µM -0.674629028358214 0.238547755737512 no 2587 0.249955742741964 3644 16667697 An anti-infammatory. SGTC_1087 pterostilbene 9.05 µM -0.67529738255824 0.23833017636874 no 2588 0.249743423273977 3659 5281727 Similar to reservatol, lowers cholesterol. SGTC_2694 st077685 81.9 µM -0.675662943393701 0.238211215865195 no 2589 0.249627334237989 3617 2838096 SGTC_1056 3448-1962 115 µM -0.675972470441332 0.238110515269637 no 2590 0.24952906194184 3624 715507 SGTC_2695 st077686 51.995 µM -0.676640449444817 0.237893276515256 no 2591 0.249317054159328 3625 2876092 SGTC_1934 st074720 32.6 µM -0.678500540886821 0.237288914481926 no 2592 0.248727190497396 3641 17250992 SGTC_2482 5981709 142.65 µM -0.67980620109157 0.236865196806381 no 2593 0.2483135898561 3631 877755 SGTC_81 0411-0046 9.971 µM -0.68078728289103 0.236547086443224 no 2594 0.248003049005543 3536 12925265 SGTC_2900 5328528 85.29 µM -0.681073495436495 0.236454327918318 no 2595 0.247912493492332 3661 795359 SGTC_2922 7999257 32.47 µM -0.681876230724262 0.236194276566063 no 2596 0.247658608224526 3631 2988377 SGTC_2835 9006588 71.43 µM -0.68577042183384 0.234934966239167 no 2597 0.246428945476336 3654 2345538 SGTC_1075 aripiprazole 15.2 µM -0.686910431868713 0.234567011091089 no 2598 0.246069586367653 3691 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM -0.687375687062078 0.234416934716793 no 2599 0.245923007338971 3657 4078 A neuroleptic. SGTC_2233 sulbentine 40.3845 µM -0.687936259237309 0.234236182741688 no 2600 0.245746460874807 3647 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3014 9081533 49.47 µM -0.688530234096764 0.23404474455881 no 2601 0.245559468852878 3665 21367265 SGTC_1651 st011928 86.1 µM -0.689227489959743 0.233820129506724 no 2602 0.24534006001083 3655 720198 SGTC_2853 9015042 58.44 µM -0.689664239710334 0.233679495159092 no 2603 0.245202679566882 3615 6457456 SGTC_195 4234-0266 16.654 µM -0.691938230422728 0.232948023537675 no 2604 0.244488060397177 3660 2303354 SGTC_2757 clomiphene 4.22 µM -0.693194159886941 0.232544576153089 no 2605 0.244093856353876 3708 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.694186884503812 0.232225954249706 no 2606 0.243782508285776 3686 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3344 9148862 3.898 µM -0.694768764878674 0.232039308664003 no 2607 0.243600112929167 3687 4905352 SGTC_2090 5301565 104.445 µM -0.696415541559576 0.231511536854065 no 2608 0.243084316424855 3696 2056344 SGTC_87 0100-0052 35.5 µM -0.696612031616108 0.231448608910569 no 2609 0.243022812095666 3738 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3350 9150499 3.57 µM -0.697563297073355 0.231144091343123 no 2610 0.242725170816572 3646 4910996 YPR165W RHO1 SGTC_1070 indatraline 8.81 µM -0.69803888064491 0.230991932163058 no 2611 0.242576439578806 3672 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_269 exalamide 29 µM -0.698057009205821 0.230986133180754 no 2612 0.24257077113485 3647 3316 A derivative of salicylamide. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.699293411232761 0.230590823493062 no 2613 0.242184341899952 3653 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_985 1493-0307 8.71 µM -0.699852694156605 0.23041213054333 no 2614 0.242009651423457 3668 3278274 SGTC_370 0180-0345 38.7 µM -0.699888787054708 0.230400601389526 no 2615 0.241998380254365 3611 3989527 SGTC_284 0988-0104 32.6 µM -0.700589440050523 0.230176855726752 no 2616 0.241779635225527 3685 4666532 SGTC_1228 0124-0032 52.5 µM -0.70213682183344 0.22968314763354 no 2617 0.241296920472996 3724 X1228 SGTC_128 0906-2981 13.371 µM -0.702219685550998 0.229656725853066 no 2618 0.241271085435377 3644 6740226 SGTC_432 NS 1619 61.3 µM -0.704719848036605 0.228860329471968 no 2619 0.240492298512623 3704 4552 A K+/calcium channel activator. SGTC_2642 cholecalciferol 100 µM -0.704908668371051 0.228800246066918 no 2620 0.240433537660773 3668 9821465 A vitamin D precursor, similar to steriods. SGTC_158 k038-0087 26.446 µM -0.70697633587627 0.228142885453055 no 2621 0.239790591871808 3637 X158 SGTC_172 1112-0046 2.638 µM -0.708479671352939 0.227665606901988 no 2622 0.239323715952107 3637 2802135 YIL048W NEO1 SGTC_2687 chenodiol 100 µM -0.709680402100489 0.22728480333526 no 2623 0.238951173947907 3696 5702181 A cholesterol synthesis inhibitor. SGTC_479 n-linoleoylglycine 10 µM -0.710588797325306 0.226996950626123 no 2624 0.238669543588627 3717 6433346 An anti-infammatory. SGTC_1269 0831-0796 3.05 µM -0.710926957252028 0.226889846879837 no 2625 0.238564750059612 3683 927758 SGTC_2589 lobaric acid 100 µM -0.711049782243166 0.226850952176721 no 2626 0.238526693641668 3691 73157 A novel microtubule depolymerizer. SGTC_3312 9133330 71.43 µM -0.713498571339566 0.22607628531192 no 2627 0.237768648431997 3732 17617324 SGTC_2064 5220758 200 µM -0.713845348092997 0.225966704546067 no 2628 0.237661407410107 3732 788518 SGTC_541 4513-1321 94 µM -0.714601428912926 0.225727888649432 no 2629 0.237427680775115 3693 747515 SGTC_2877 9040724 71.43 µM -0.716316676922869 0.225186639653805 no 2630 0.236897915760216 3682 6463895 SGTC_724 3910-0327 137 µM -0.71744160292094 0.224832067170382 no 2631 0.236550828533035 3717 2885483 SGTC_1387 3342-1166 1.8 µM -0.719193702007415 0.224280443019228 no 2632 0.236010789669721 3702 3418228 SGTC_1182 1222-0449 220 µM -0.71920960253868 0.224275440477764 no 2633 0.236005891858185 3683 658318 SGTC_2485 5633444 17.78 µM -0.719382560552924 0.224221029430058 no 2634 0.23595261953601 3714 5724239 SGTC_552 k242-0005 476 µM -0.719745317490263 0.224106933685428 no 2635 0.235840909299041 3734 4088318 SGTC_1891 st059073 26.2 µM -0.720979878538159 0.223718881847739 no 2636 0.235460947370743 3730 688754 SGTC_1431 4049-0260 9.09 µM -0.722143400444026 0.22335350922795 no 2637 0.235103158648773 3684 3854841 SGTC_1724 st037281 8.293 µM -0.72257071576052 0.223219407698682 no 2638 0.234971832516293 3729 574124 YDL195W SEC31 SGTC_632 0781-2353 4.65 µM -0.722572310119135 0.223218907437537 no 2639 0.234971342600521 3767 6811515 YHR007C ERG11 SGTC_926 2268-1401 59.4 µM -0.72276011668028 0.223159983927433 no 2640 0.234913637201417 3708 2931578 SGTC_1333 1482-0047 286 µM -0.723030895665426 0.223075043761853 no 2641 0.234830451502579 3688 3811116 SGTC_2892 9047358 58.44 µM -0.723054158449124 0.223067747360546 no 2642 0.23482330572927 3708 6466771 SGTC_2909 7941780 10.49 µM -0.724702543650284 0.222551075381046 no 2643 0.234317267154518 3706 1243215 SGTC_3299 9121982 43.1275 µM -0.724966147140996 0.222468514493047 no 2644 0.234236399405165 3759 17594604 YPL160W CDC60 SGTC_2022 5136654 200 µM -0.725783146620578 0.2222127403947 no 2645 0.233985860123235 3728 1713771 SGTC_777 1315-0167 517 µM -0.727979984803023 0.221525819713344 no 2646 0.233312919309082 3745 4221767 SGTC_1788 fluconazole 20 µM -0.72998260894643 0.220900685994985 no 2647 0.232700407517297 3737 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2192 5915882 198.485 µM -0.730140953217118 0.220851300797621 no 2648 0.232652015350615 3689 2876149 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.732432064187581 0.220137445527961 no 2649 0.231952446998515 3788 688801 SGTC_100 0086-0128 49.5915 µM -0.73605303893986 0.219011939558701 no 2650 0.230849210191372 3729 93297 SGTC_1118 chelidonine 707.474 nM -0.736989021647738 0.218721547685099 no 2651 0.230564512798189 3731 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1838 st055369 84.5 µM -0.737042331627058 0.218705014752444 no 2652 0.230548303436524 3713 676036 SGTC_2259 7964009 200 µM -0.737092401139462 0.218689487435289 no 2653 0.230533079946923 3742 313134 SGTC_3154 9100113 49.47 µM -0.741368232362066 0.217365829746742 no 2654 0.22923510033323 3758 25237525 SGTC_2420 aureobasidin a 50 nM -0.741481900472999 0.217330705052595 no 2655 0.22920065102914 3784 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_605 1315-0399 119 µM -0.74219267153729 0.217111143329981 no 2656 0.228985304054102 3817 24020461 SGTC_15 0266-0086 27.098 µM -0.743251259075807 0.216784376568484 no 2657 0.228664787388209 3821 1712902 YIL048W NEO1 SGTC_483 fpl-64176 144 µM -0.743885141251498 0.216588844846515 no 2658 0.228472982678095 3769 3423 SGTC_1298 1079-1278 263 µM -0.744021602229457 0.216546764490481 no 2659 0.228431703143169 3775 2840950 SGTC_2762 leflunomide 42.06 µM -0.744695247803485 0.216339102298355 no 2660 0.228227986333003 3733 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1163 k060-0048 49.9 µM -0.745193420281404 0.216185606710158 no 2661 0.228077399965499 3755 6809982 SGTC_629 3448-6466 76.7 µM -0.747256419176055 0.215550632637435 no 2662 0.227454396831 3748 573744 SGTC_2481 5478948 45.16 µM -0.747397216225621 0.215507335928935 no 2663 0.22741191262986 3765 77792 SGTC_640 3381-0960 37.1 µM -0.748535201957852 0.21515757744616 no 2664 0.227068700127727 3786 1745025 SGTC_188 3229-0966 278.469 µM -0.74900861847522 0.215012170583846 no 2665 0.226926005430525 3821 5722370 SGTC_1783 st039459 87.517 µM -0.749490592195207 0.214864194067699 no 2666 0.226780783436239 3849 729761 SGTC_924 2046-0044 21.3 µM -0.752464549522895 0.213952433485071 no 2667 0.22588587050626 3747 3623589 SGTC_1643 st009866 20.2 µM -0.752643599043125 0.213897612176621 no 2668 0.225832055354122 3739 3156273 YOR207C RET1 SGTC_160 3453-0671 289.699 µM -0.753843841364816 0.213530333700998 no 2669 0.225471497603445 3785 5322268 SGTC_314 1671-0008 2.74 µM -0.754779552824612 0.213244257726512 no 2670 0.225190632205868 3694 3913060 SGTC_1834 st055981 52.8 µM -0.755633989914098 0.212983225172008 no 2671 0.224934335521386 3807 471719 YDL150W RPC53 SGTC_2234 tolnaftate 200 µM -0.756140066768703 0.212828705452331 no 2672 0.22478261086504 3736 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2802 7925815 54.55 µM -0.756426824702363 0.212741179115558 no 2673 0.224696665005023 3781 1262923 SGTC_1025 k007-0731 70 µM -0.756606743128133 0.212686273839199 no 2674 0.224642750141443 3741 6256118 SGTC_2071 5230951 39.92 µM -0.758111175072266 0.212227493887489 no 2675 0.224192215130267 3797 1799272 SGTC_2297 7971671 152.32 µM -0.759297792828768 0.211866040517053 no 2676 0.223837218778463 3743 909016 SGTC_750 4073-0104 132 µM -0.760221134776443 0.211585032409915 no 2677 0.223561206908905 3629 22330957 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.761110655460582 0.211314523867088 no 2678 0.223295488293671 3743 2346 DNA damaging agent; causes G2/M arrest. SGTC_1997 st073024 93.8 µM -0.761504684227412 0.211194762146799 no 2679 0.223177841048565 3749 686268 SGTC_643 k048-0106 28.4 µM -0.762378455646359 0.210929328623223 no 2680 0.222917080438787 3799 6763920 SGTC_1209 2323-2347 50.3 µM -0.763494334010173 0.210590632624683 no 2681 0.222584320069948 3725 5412760 SGTC_2767 sibutramine 71.45 µM -0.76353793688681 0.210577404581778 no 2682 0.222571323231283 3794 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3341 9147222 25.867 µM -0.764867890827106 0.210174163487729 no 2683 0.222175107840849 3779 1939759 SGTC_2985 9022375 71.43 µM -0.765405221491051 0.210011373936398 no 2684 0.222015142342996 3765 4939335 SGTC_2952 9073731 13.78 µM -0.7677875375696 0.209290521050906 no 2685 0.221306709830555 3841 16457353 SGTC_3026 9090633 49.47 µM -0.768298543769597 0.209136088195646 no 2686 0.22115491980889 3794 25236842 SGTC_544 k015-0020 52.4 µM -0.769213994014782 0.208859594808857 no 2687 0.220883142132048 3795 3008304 SGTC_3163 9099914 49.47 µM -0.770124221756985 0.208584892419024 no 2688 0.220613104583166 3785 16268368 SGTC_568 1193-0097 7.48 µM -0.77023903799912 0.208550256560156 no 2689 0.220579055450804 3664 3646150 SGTC_516 3992-2719 87.3 µM -0.770485602052211 0.208475888668564 no 2690 0.220505946250082 3743 5350887 YDR037W KRS1 SGTC_655 k060-0012 42 µM -0.771052337806169 0.208305010867532 no 2691 0.220337954946856 3784 5994525 SGTC_68 0986-0284 82.829 µM -0.77148261075039 0.208175333477996 no 2692 0.220210462838613 3864 423278 YIL048W NEO1 SGTC_1605 st000082 49.1 µM -0.771692422625867 0.208112116814094 no 2693 0.220148309836801 3792 1114022 SGTC_2761 levamisole 97.89 µM -0.771818208069553 0.208074222885556 no 2694 0.220111052981577 3763 26879 An alkaline phosphatase inhibitor. SGTC_623 k072-0108 16.9 µM -0.77231426262298 0.207924821962117 no 2695 0.219964160010425 3791 5382803 SGTC_1496 4469-0713 57.4 µM -0.773596044932396 0.207539070204658 no 2696 0.219584855848236 3754 746691 SGTC_879 0831-1030 162 µM -0.773605247090146 0.207536302349771 no 2697 0.219582134110685 3823 1549252 SGTC_626 0214-0009 33 µM -0.777306889291861 0.20642468071399 no 2698 0.218488865710572 3841 3437874 SGTC_6 0844-0013 19.835 µM -0.777576012319409 0.206343999527589 no 2699 0.218409503486522 3897 1584900 SGTC_20 0481-0013 4.944 µM -0.778342983321984 0.206114169569874 no 2700 0.218183420990038 3808 182045 SGTC_962 1254-0300 21.5 µM -0.780531651102704 0.205459150140303 no 2701 0.217539002437605 3755 7340576 SGTC_152 4469-0003 551.229 µM -0.780831767059089 0.205369428601178 no 2702 0.217450723775942 3741 697280 SGTC_447 ml7 120 µM -0.781751158632358 0.205094715628456 no 2703 0.217180414871384 3825 4216 Selective myosin light chain kinase inhibitor. SGTC_229 benomyl 22.8748 µM -0.781849033711963 0.205065483553385 no 2704 0.217151650205954 3817 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2943 9068529 45.32 µM -0.783175398559382 0.204669586112076 no 2705 0.216762059764988 3810 3270634 SGTC_362 0310-0100 9.03 µM -0.783846802693954 0.20446935680665 no 2706 0.216565003779274 3876 790235 SGTC_1604 st002052 72.4 µM -0.784445119827107 0.204291022128784 no 2707 0.216389486068633 3831 6254834 YHR062C RPP1 SGTC_62 0180-0423 3.232 µM -0.785065712146476 0.20410614598074 no 2708 0.216207520896844 3769 30102 YGL099W LSG1 SGTC_2354 9060492 162 µM -0.785945855000286 0.203844119983024 no 2709 0.215949604364484 3881 6471895 SGTC_331 k048-0133 24.5 µM -0.786516516295997 0.203674336461897 no 2710 0.215782473424118 3791 6813582 SGTC_2356 9061756 188.97 µM -0.78682006769001 0.203584058018166 no 2711 0.215693602155872 3824 20104043 SGTC_2389 9091542 195.52 µM -0.787369713016153 0.203420650148512 no 2712 0.215532735549863 3819 3626624 YOL127W RPL25 SGTC_3267 9137951 49.47 µM -0.788524294766252 0.203077651463378 no 2713 0.215195046790317 3813 16643986 SGTC_1377 2944-0135 198 µM -0.789157367165261 0.202889727429225 no 2714 0.215010018021111 3867 1894137 SGTC_2300 7976697 71.57 µM -0.789248619414296 0.202862648272726 no 2715 0.214983355245427 3742 2236109 SGTC_2972 9093619 59.92 µM -0.791011864818133 0.202339828220335 no 2716 0.21446853392604 3823 25236256 SGTC_1034 k072-0165 12.7 µM -0.793659772284369 0.201556212427134 no 2717 0.213696762593288 3816 5835461 SGTC_1848 st056003 16.4 µM -0.793829430005232 0.201506066360092 no 2718 0.213647368580355 3856 146492 SGTC_523 1934-0222 13.7 µM -0.795463330538132 0.2010235139398 no 2719 0.213172016671181 3816 1361595 SGTC_3023 9089636 49.47 µM -0.795608704377494 0.200980613171944 no 2720 0.21312975285477 3904 17249241 SGTC_2764 methyldopa 94.69 µM -0.798326772793607 0.200179505255174 no 2721 0.212340442707871 3808 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1366 1683-0113 21.9 µM -0.80075755839114 0.199464697538042 no 2722 0.21163600682529 3839 708623 SGTC_1194 1488-0194 225 µM -0.803341165275635 0.19870663735786 no 2723 0.210888785447513 3795 1391452 SGTC_2400 5203494 178.7 µM -0.80342546018328 0.198681933555696 no 2724 0.210864432069953 3766 6777674 SGTC_2227 7312221 64.1025 µM -0.803727535844743 0.198593421267718 no 2725 0.21077717388282 3871 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2932 9016711 44.54 µM -0.805111049917032 0.198188336778343 no 2726 0.210377799927254 3839 7117328 SGTC_1634 st006576 41 µM -0.805619557418814 0.198039574331048 no 2727 0.210231122647882 3801 3915356 SGTC_521 r062-0005 13.8 µM -0.806905951834272 0.197663544421073 no 2728 0.209860334753776 3763 2832033 SGTC_207 4185-0010 4.486 µM -0.807746178743352 0.197418168253116 no 2729 0.209618357010034 3889 3761753 SGTC_2276 7947513 42.08 µM -0.80787531516574 0.197380472158324 no 2730 0.20958118144288 3741 2105100 SGTC_2132 5317594 122.667 µM -0.808397646510367 0.197228043312446 no 2731 0.209430853179826 3825 794577 SGTC_1958 st076513 41.9 µM -0.809519558274488 0.196900883328006 no 2732 0.209108178742847 3820 732122 YGL099W LSG1 SGTC_3206 9114350 49.47 µM -0.809522136016178 0.196900132012891 no 2733 0.20910743769259 3772 17087243 SGTC_710 3448-4187 58 µM -0.810643497510641 0.196573461777727 no 2734 0.208785214899642 3833 3946412 SGTC_3228 9131799 49.47 µM -0.811083098314667 0.196445488797036 no 2735 0.208658975655248 3852 17015818 SGTC_224 benfluorex 43.875 µM -0.812566118817468 0.196014136650756 no 2736 0.208233431802123 3820 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1624 st003710 6.25 µM -0.81288482733987 0.195921511978515 no 2737 0.208142047192421 3851 24207033 SGTC_2779 methotrexate 400 µM -0.813493233270732 0.19574476774165 no 2738 0.207967662179848 3878 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2124 5246320 200 µM -0.813999758483072 0.195597694093182 no 2739 0.207822544661805 3869 579342 SGTC_2048 5246248 200 µM -0.81417671698658 0.195546328594562 no 2740 0.207771860833135 3826 677046 SGTC_740 k014-0057 261 µM -0.814711292506196 0.195391207857241 no 2741 0.207618793952373 3859 4012779 SGTC_508 roscovitine 141 µM -0.816236015781113 0.194949181281188 no 2742 0.207182580799095 3904 160355 A CDKinase inhibitor. SGTC_2911 7942208 15.64 µM -0.81741354769446 0.19460822407022 no 2743 0.206846068057414 3884 1243384 SGTC_2072 5231554 129 µM -0.817771707113112 0.194504590157576 no 2744 0.206743778171248 3904 789545 SGTC_3303 9125618 40.5795 µM -0.819682123628864 0.193952376183376 no 2745 0.206198671717251 3905 22695467 SGTC_2813 7971799 71.43 µM -0.822607860486834 0.193108533756693 no 2746 0.205365513594964 3940 2234054 SGTC_1028 k015-0029 4.8 µM -0.824109564338858 0.192676283450849 no 2747 0.204938653080574 3836 4588309 SGTC_1081 sertraline 6 µM -0.825081976833547 0.192396699972951 no 2748 0.204662525652955 3880 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_933 2914-0560 114 µM -0.827323832288502 0.191753078071816 no 2749 0.204026769609261 3929 463887 SGTC_1477 0139-0234 16 µM -0.829281653784296 0.191192080250073 no 2750 0.203472524872707 3891 620880 SGTC_691 1548-0686 185 µM -0.830500997272908 0.190843196329099 no 2751 0.203127792112002 3895 46495133 SGTC_9 0092-0002 10.449 µM -0.831634352934108 0.190519266126882 no 2752 0.202807682705481 3846 759368 SGTC_2149 5554786 194.827 µM -0.831807134461585 0.190469912223264 no 2753 0.202758908103891 3906 745063 YPR165W RHO1 SGTC_3192 9110362 49.47 µM -0.832335013664927 0.190319175649205 no 2754 0.202609936188174 3891 16649480 SGTC_647 0140-0236 81 µM -0.832927977682119 0.190149941434397 no 2755 0.202442674835296 3887 990837 SGTC_2350 9023895 38.85 µM -0.834664927728896 0.189654741589852 no 2756 0.2019531970034 3916 2997209 SGTC_339 3091-4833 71.4 µM -0.834739483815411 0.189633503619002 no 2757 0.201932202739311 3806 3240077 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.836567644261006 0.189113193553507 no 2758 0.201417819543665 3883 3256 An antibiotic and ribosome inhibitor. SGTC_2608 thymoquinone 42.66 µM -0.83833431149647 0.188611221192016 no 2759 0.200921485343438 3865 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3245 9134821 49.47 µM -0.839686001067884 0.188227713828677 no 2760 0.200542232526301 3886 17014901 SGTC_1763 st044482 94.5 µM -0.841154084092816 0.187811728318145 no 2761 0.2001308097739 3927 88505 SGTC_2094 5332512 191.667 µM -0.841395243061219 0.187743449570338 no 2762 0.200063274754298 3935 755774 SGTC_1692 fluoroquinolonic acid 71 µM -0.841912989542707 0.187596913079761 no 2763 0.199918329466994 3937 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1286 0929-0070 131 µM -0.842791651184371 0.187348389459226 no 2764 0.19967248904615 3992 1420408 SGTC_1326 1431-2094 10.8 µM -0.843853096096497 0.18704843839315 no 2765 0.199375750473669 3879 616278 SGTC_2990 9074105 71.4286 µM -0.844721120211269 0.186803366561283 no 2766 0.199133282267415 3837 6502001 SGTC_1226 3909-7979 35.4 µM -0.845097563508207 0.186697146014904 no 2767 0.199028184293786 3919 6615510 SGTC_1102 cgs 12066b 26.1 µM -0.846936657606586 0.186178748809553 no 2768 0.198515214304735 3901 6438352 A 5-HT1B full agonist. SGTC_1987 st072290 61.9 µM -0.849271437032872 0.185521916172909 no 2769 0.197865135322253 3926 54697379 SGTC_1690 st023502 41.2 µM -0.849837481712731 0.185362890316381 no 2770 0.197707723870649 3879 24207482 SGTC_36 0335-0881 14.2 µM -0.850919632033156 0.185059104223647 no 2771 0.197406999243406 3819 23828853 SGTC_2875 9039966 71.43 µM -0.853487456676387 0.184339491595072 no 2772 0.196694520321644 3945 6463691 SGTC_1638 st008370 60.6 µM -0.855196009894565 0.183861648988519 no 2773 0.196221322392667 3877 24207134 SGTC_2689 tacrolimus 100 µM -0.85758701502732 0.183194237011494 no 2774 0.195560273829668 3927 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1022 4477-0945 21.3 µM -0.858036497827141 0.18306893980048 no 2775 0.195436155107067 3859 4648966 SGTC_851 0394-0702 453 µM -0.859719547004002 0.182600250375327 no 2776 0.194971828536442 3870 762646 SGTC_983 1491-0821 12.2 µM -0.859754239179 0.182590597313239 no 2777 0.194962264576499 3934 46495113 SGTC_848 0368-0089 85.6 µM -0.861346877305316 0.182147790566313 no 2778 0.194523512315986 3930 762535 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.861921227936511 0.181988266677915 no 2779 0.194365433315917 3952 6710655 SGTC_2988 9073640 71.4286 µM -0.863589026913281 0.18152553666914 no 2780 0.193906847110432 3981 9102229 SGTC_1241 0364-0022 50.8 µM -0.863843114805195 0.181455104805854 no 2781 0.193837039783202 3944 4563895 SGTC_1588 farnesol 29.9 µM -0.864616578815179 0.181240809857935 no 2782 0.193624634962261 3909 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2874 9043904 71.43 µM -0.865108421937514 0.181104622907332 no 2783 0.193489641317623 3886 4463428 SGTC_1831 st055328 12 µM -0.866828964002704 0.180628724792863 no 2784 0.193017864881223 3896 1103068 SGTC_2624 nerol 100 µM -0.86786334455525 0.180342995231295 no 2785 0.192734573833413 3839 637566 A natural product oil. SGTC_741 4582-0002 126 µM -0.868067478484942 0.180286640323865 no 2786 0.192678696669212 3888 2912688 SGTC_1389 3405-0187 19 µM -0.868676965439641 0.180118446059802 no 2787 0.192511921960757 3894 799890 SGTC_952 1185-0122 232 µM -0.86882307631286 0.180078139886936 no 2788 0.19247195456937 3857 678600 SGTC_2597 laccaic acid a 100 µM -0.870444550469667 0.17963121990101 no 2789 0.192028754654574 3948 5491415 A textile dye. SGTC_216 k038-0035 28.382 µM -0.870453029826301 0.179628884605721 no 2790 0.192026438622295 3843 4444231 YPR107C YTH1 SGTC_2553 4-methylesculetin 85.09 µM -0.871477088748116 0.179346989356478 no 2791 0.191746855195537 3966 5319502 SGTC_1797 st048695 56.8 µM -0.872357550082976 0.179104845088702 no 2792 0.191506675453698 3908 592262 YIL048W NEO1 SGTC_2720 fluspirilene 36.88 µM -0.873621519246453 0.178757588335006 no 2793 0.191162201574381 3933 3396 An atypical antipsychotic. SGTC_961 1252-1571 372 µM -0.876805945247359 0.177884595281978 no 2794 0.190296024673153 3928 6813498 SGTC_2308 7584454 197.62 µM -0.877837872427165 0.177602275899998 no 2795 0.190015854278037 3964 893577 SGTC_3057 9095946 49.47 µM -0.880437609307907 0.1768922822822 no 2796 0.189311145005555 3962 24540043 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.880853482609776 0.176778873061249 no 2797 0.189198563908188 3959 91467 include heat shock SGTC_678 1218-2179 85.9 µM -0.880990033403644 0.176741645497889 no 2798 0.189161607222995 3917 6820081 YOR116C RPO31 SGTC_1499 4480-0877 67.3 µM -0.881354586511361 0.176642282411214 no 2799 0.189062964803543 3869 2861909 SGTC_1356 1502-0781 85.8 µM -0.881887210070558 0.176497173333279 no 2800 0.188918902097024 3905 567702 SGTC_2057 5236571 38.335 µM -0.883112305893387 0.176163691923464 no 2801 0.188587797978237 3947 54684039 YBR257W POP4 SGTC_2299 7976368 114.88 µM -0.883272334954785 0.176120160133616 no 2802 0.188544573690145 3997 2979718 SGTC_2109 5483026 200 µM -0.884045673037472 0.175909889374796 no 2803 0.188335779055186 3958 759335 SGTC_1791 st048313 56.1 µM -0.884308120738208 0.175838565946525 no 2804 0.188264952861431 3935 1204976 SGTC_361 000s-0510 1.45 µM -0.886180369774489 0.175330290499163 no 2805 0.187760169965037 3943 660 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.886618171844055 0.17521157114673 no 2806 0.187642253488991 3981 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_878 0828-0289 13.7 µM -0.887637727839763 0.174935294494139 no 2807 0.187367826301408 3913 745350 YLR208W SEC13 SGTC_2801 7907800 81.82 µM -0.887838411173541 0.174880946421331 no 2808 0.187313838925578 3995 6620925 SGTC_3324 9138759 60.749 µM -0.887842536758733 0.174879829263073 no 2809 0.187312729170892 3996 45595710 SGTC_3088 9117578 49.47 µM -0.888813445804088 0.174617044869632 no 2810 0.187051674215749 3992 678341 SGTC_322 k048-0136 19.3 µM -0.889448611023816 0.174445268003455 no 2811 0.1868810148385 4015 6823282 SGTC_109 0132-0036 33.701 µM -0.89622168074604 0.172620208594289 no 2812 0.185067189259215 3778 67274 A color developer. SGTC_1408 3909-7976 48.8 µM -0.89804530805594 0.172130904896448 no 2813 0.184580697476722 4017 24152374 SGTC_2572 astragaloside iv 100 µM -0.898545305678749 0.171996903592703 no 2814 0.184447451405328 4049 45006101 An anti-inflammatory agent. SGTC_2303 7774051 200 µM -0.900574763807564 0.17145368491502 no 2815 0.183907228732968 3964 2953184 SGTC_909 3448-9333 149 µM -0.90557746082422 0.17011931739413 no 2816 0.182579771559635 3902 3344074 SGTC_2926 9010726 65.15 µM -0.905589964433592 0.170115990670702 no 2817 0.182576461262717 4017 2994293 SGTC_1018 4259-0013 28.1 µM -0.907789670666089 0.169531383399181 no 2818 0.181994678383683 4054 6801262 SGTC_950 1165-0508 94.1 µM -0.909337898077891 0.169120690928825 no 2819 0.181585895844977 4005 6148369 SGTC_1857 st056007 79.3 µM -0.90944429505187 0.169092490883514 no 2820 0.181557824690447 3975 619834 SGTC_1748 st037455 53.6035 µM -0.910353117536632 0.168851734590161 no 2821 0.181318156980563 4025 580690 SGTC_1550 gossypolone 36.6 µM -0.910548538112595 0.168799994482275 no 2822 0.181266648052793 3989 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2232 chlorophetanol 41.5365 µM -0.910993836501772 0.168682134072955 no 2823 0.181149310601506 4046 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_235 0330-0087 5 mM -0.916067048780016 0.167343104814254 no 2824 0.179815864617399 4004 46494818 YHR062C RPP1 SGTC_2726 cimetidine 79.27 µM -0.917136098504256 0.167061814879622 no 2825 0.179535663488878 3973 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1442 4112-3290 3 µM -0.920941368945317 0.166063042241838 no 2826 0.178540519321039 3964 704353 SGTC_1863 st057641 20.1 µM -0.921998241320656 0.165786330009286 no 2827 0.178264746505372 4005 3921635 SGTC_187 1488-2104 32.728 µM -0.922324684797917 0.165700920277965 no 2828 0.178179620940455 4000 2852859 SGTC_1250 0485-0349 40.2 µM -0.923002236576583 0.165523738405906 no 2829 0.17800301984185 4005 6842794 YDL195W SEC31 SGTC_40 0327-0103 19.753 µM -0.92318941966458 0.165474811064844 no 2830 0.177954250799636 3876 409036 SGTC_3342 9147791 14.508 µM -0.923928476399683 0.165281722188375 no 2831 0.177761777856442 3905 1838168 SGTC_394 menadione 8.33 µM -0.92403516493387 0.165253860369365 no 2832 0.177734003755703 3991 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_759 3486-0358 89.3 µM -0.924238740350318 0.165200704876541 no 2833 0.177681014803334 3965 875103 SGTC_1555 citronellol 128 µM -0.924269104708817 0.165192777399952 no 2834 0.17767311207299 3933 8842 A terpine precursor. SGTC_2652 actinonin 100 µM -0.926366780006771 0.164645715881688 no 2835 0.17712770098361 3988 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1747 st037496 66.6 µM -0.927075851198984 0.164461060008398 no 2836 0.176943576660398 4011 723305 SGTC_2283 7944793 200 µM -0.927781277318327 0.164277486640563 no 2837 0.17676051891754 4037 2970533 SGTC_1196 1588-0294 184 µM -0.928613127138507 0.164061184760064 no 2838 0.176544808174068 4010 6144269 SGTC_2947 9072639 7.68 µM -0.92939782042281 0.163857314182884 no 2839 0.176341478474183 4038 16488146 SGTC_1719 st032227 49.2 µM -0.929684177771703 0.163782956857574 no 2840 0.176267314483295 4016 3125804 SGTC_2465 5809242 33.21 µM -0.93048907918685 0.163574068482402 no 2841 0.176058957953231 4025 2731748 SGTC_2925 9010536 32.5 µM -0.930870396807817 0.163475169179664 no 2842 0.175960304645952 3967 2994177 SGTC_830 4076-0286 57.8 µM -0.933545845601564 0.162782351831055 no 2843 0.1752691055872 4075 6866659 SGTC_2373 9071805 200 µM -0.938211335539051 0.161578781263958 no 2844 0.174067907050452 4000 10149009 SGTC_881 0833-0569 170 µM -0.941856792735638 0.1606423994395 no 2845 0.173132981922293 4015 5418700 SGTC_1293 1000-1278 195 µM -0.941975842122397 0.160611879977592 no 2846 0.173102504178242 4077 678847 SGTC_3193 9111931 49.47 µM -0.945385229245761 0.159739458004655 no 2847 0.17223112016978 4046 17087244 SGTC_1949 st076024 69.1 µM -0.947933205804815 0.159089489103746 no 2848 0.171581729547775 3953 2921930 SGTC_1618 st003135 44.5 µM -0.948088724884579 0.159049873583576 no 2849 0.171542143865466 3922 1270615 SGTC_967 1306-0166 352 µM -0.94866342327058 0.158903536203905 no 2850 0.171395911305112 4004 4437607 SGTC_3356 9151811 4.48 µM -0.948947331587348 0.158831276248902 no 2851 0.171323699971984 4016 1859254 YPR165W RHO1 SGTC_2199 6590217 200 µM -0.949067753181765 0.158800633216189 no 2852 0.171293076931538 3932 703109 SGTC_956 1185-0240 191 µM -0.951607062688442 0.158155371323417 no 2853 0.170648149164393 4027 1416193 SGTC_1842 st055362 61.2 µM -0.951776092587168 0.158112480443837 no 2854 0.170605274604008 3989 676032 SGTC_811 0416-0114 265 µM -0.953220823115847 0.15774619551608 no 2855 0.170239099040379 4107 6612453 SGTC_163 TUB2.036 7.546 µM -0.954932912339588 0.157312848890639 no 2856 0.169805812271279 4022 15992207 YJR013W GPI14 SGTC_908 3448-7491 47.7 µM -0.959452627772331 0.156172627943103 no 2857 0.168665386780309 4042 1203031 SGTC_1240 0356-0016 42.1 µM -0.960349883948938 0.155946920123301 no 2858 0.168439575938064 4030 4305613 SGTC_3308 9128332 17.569 µM -0.960955895471147 0.155794597595683 no 2859 0.168287172153232 4066 17332805 YDL196W YDL196W SGTC_2051 5263410 176 µM -0.961189775958231 0.155735837388977 no 2860 0.168228378070574 4051 227584 SGTC_2009 4012297 12.05 µM -0.96227131959165 0.155464300104809 no 2861 0.167956665921699 4047 45595307 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.963380701404707 0.155186098366582 no 2862 0.167678253731593 4079 5379071 SGTC_1696 st025591 34.7925 µM -0.963734061637667 0.155097554617726 no 2863 0.167589636344651 4051 2787147 SGTC_2703 st077852 53.4 µM -0.964461695808115 0.154915331719709 no 2864 0.167407251768382 4096 6281836 SGTC_1935 st074532 41.6 µM -0.96594004171291 0.154545542229567 no 2865 0.167037092187667 4038 2829742 SGTC_2337 9009472 200 µM -0.970048514259002 0.153520926016085 no 2866 0.166011155253143 4002 5742383 SGTC_1896 st058441 89 µM -0.972506818286282 0.152910003212263 no 2867 0.165399237262448 4062 688759 SGTC_1591 genipin 88.4 µM -0.973403463533431 0.152687576123216 no 2868 0.165176409098849 4102 442424 A DNA cross-linking agent. SGTC_27 0485-0001 32.618 µM -0.974308779610951 0.152463215949435 no 2869 0.164951623347592 3981 2054479 SGTC_374 0880-0231 82.3 µM -0.976536045390665 0.151912174939267 no 2870 0.164399447246138 3982 6833587 SGTC_1475 4092-1048 11.7 µM -0.977427091511525 0.151692094944219 no 2871 0.164178878115826 4090 2881759 SGTC_1266 0828-0227 32.9 µM -0.979206834186632 0.151253149885633 no 2872 0.163738896259903 4073 3913820 SGTC_1405 3909-7894 12 µM -0.979306605417077 0.151228567942147 no 2873 0.163714253836781 4072 7104060 SGTC_3035 9091303 49.47 µM -0.982240075878003 0.150506998203453 no 2874 0.162990794212052 4133 25237002 SGTC_788 1182-0090 188 µM -0.983485099951693 0.150201443819606 no 2875 0.162684372537045 4116 5715185 SGTC_232 clozapine 119 µM -0.984642764630686 0.14991770043202 no 2876 0.162399787929201 4025 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_752 1896-0090 130 µM -0.984713573623596 0.149900356769995 no 2877 0.162382391726801 4042 772567 SGTC_359 0081-0058 15.9 µM -0.984981702202172 0.149834694591573 no 2878 0.162316529461766 4177 3494159 SGTC_3134 9127454 49.47 µM -0.986138727952892 0.149551569851724 no 2879 0.162032520730999 4108 24262820 SGTC_3103 9120822 49.47 µM -0.98645631703773 0.14947391814446 no 2880 0.161954620538312 4103 17141819 SGTC_108 0509-0257 621.132 µM -0.988372156446384 0.149006059209264 no 2881 0.161485209328358 4038 536624 SGTC_455 paf C-16 10 µM -0.989306253365951 0.148778302553767 no 2882 0.161256662716416 4044 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2471 5466956 24.79 µM -0.989375715492132 0.148761375214733 no 2883 0.161239675767608 4033 724419 SGTC_2087 5276107 200 µM -0.991343306977758 0.148282424258498 no 2884 0.160758986542052 4040 144405 SGTC_1373 2887-0003 58.5 µM -0.992045947474677 0.148111637809743 no 2885 0.160587556078089 4055 776948 SGTC_464 bw-b 70c 158 µM -0.997272368121827 0.14684541633095 no 2886 0.159316161120274 4130 5353454 SGTC_2396 5342950 42.78 µM -1.0002625309112 0.146124255283375 no 2887 0.158591737475277 4083 1886677 SGTC_2728 chlorpromazine 9.18 µM -1.00211361481821 0.145679009039721 no 2888 0.158144361508226 4123 2726 A thorazine and dopamine antagonist. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.00646370970972 0.144636262402918 no 2889 0.157096280087934 4143 688798 SGTC_2083 5306046 65.942 µM -1.0064714774806 0.144634404924933 no 2890 0.157094412670931 4106 539837 SGTC_925 2064-1272 59.6 µM -1.00953364432119 0.14390341203631 no 2891 0.156359387346321 4080 6815817 SGTC_2846 9008642 19.48 µM -1.01036962051833 0.143704283669919 no 2892 0.156159118547596 4172 2992898 SGTC_2202 7226349 200 µM -1.01078471021473 0.143605478998678 no 2893 0.156059741319268 4055 844334 SGTC_294 k038-0071 157 µM -1.01184903942167 0.143352344032718 no 2894 0.155805119194035 4096 24152826 SGTC_2140 5586273 200 µM -1.01746108859026 0.142022585827028 no 2895 0.154467066987051 4072 854421 SGTC_209 4077-0173 175.592 µM -1.01942151489694 0.141560042901878 no 2896 0.154001448145808 4088 15993494 SGTC_1836 st055642 81 µM -1.02021119144475 0.141374015327271 no 2897 0.1538141555272 4119 8571 SGTC_3348 9149464 3.537 µM -1.02248928082884 0.140838284579747 no 2898 0.153274691715537 4068 1951442 SGTC_2721 ifenprodil 61.44 µM -1.02383566823159 0.140522307497758 no 2899 0.152956450055219 4112 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.02481020534666 0.140293898596831 no 2900 0.152726375057267 4171 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_98 0074-0023 107.663 µM -1.02560800815313 0.14010709991666 no 2901 0.152538195599692 4141 3563821 SGTC_3304 9125678 46.087 µM -1.02674965796263 0.139840086441065 no 2902 0.152269179919794 4055 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1122 capsaicin 818.572 nM -1.02698288472927 0.139785581038769 no 2903 0.15221426168028 4186 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_500 h-89 112 µM -1.02781293524866 0.139591714312647 no 2904 0.152018915200487 4143 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1785 bathophenanthroline 24 µM -1.02872594183002 0.139378683614068 no 2905 0.151804237993148 4039 72812 An iron chelator. SGTC_2931 9014674 55.67 µM -1.03144777591716 0.138744914430818 no 2906 0.15116544321232 4095 2996810 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.03153880590857 0.13872375240296 no 2907 0.151144110081742 4144 115019 SGTC_1213 1315-0166 115 µM -1.03355936378025 0.138254592932704 no 2908 0.150671102414533 4210 768401 SGTC_1781 st038725 66.3 µM -1.03375006560245 0.138210369226929 no 2909 0.150626510546995 4099 4270275 YIL048W NEO1 SGTC_768 0384-0033 77.3 µM -1.03897634464894 0.137002149616804 no 2910 0.149407868983195 4102 3965305 YMR134W ERG29 SGTC_1458 k015-0034 6.33 µM -1.03952217071659 0.136876382193387 no 2911 0.149280976222527 4166 3598957 SGTC_131 0141-0277 33.849 µM -1.04283800281349 0.136114055165117 no 2912 0.148511663614331 4109 1547771 SGTC_872 0588-0139 234 µM -1.0469668429727 0.13516888243039 no 2913 0.147557435450089 4097 2047100 SGTC_3006 9075424 71.4286 µM -1.04867531128727 0.134779099823356 no 2914 0.147163790445532 4095 7465181 SGTC_2118 5526350 200 µM -1.05047115688101 0.134370214466751 no 2915 0.146750772614492 4173 743594 SGTC_1347 1493-0251 600 nM -1.05051599801459 0.134360015768229 no 2916 0.146740469780862 4196 3986378 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.05236982940068 0.13393884426019 no 2917 0.146314952662875 4183 6708784 An antioxidant flavonoid SGTC_1011 4112-3381 17.4 µM -1.05359912384317 0.13366006194374 no 2918 0.146033245252787 4221 2877139 SGTC_3123 9126162 49.47 µM -1.0570916069107 0.132870206258331 no 2919 0.145234890662585 4213 25239884 SGTC_2890 9046729 58.44 µM -1.05752511553004 0.132772389171856 no 2920 0.145135999224691 4100 903329 SGTC_2428 5615643 7.78 µM -1.05884465820686 0.132474952219891 no 2921 0.144835265767944 4193 2253075 SGTC_1733 st037357 54.9 µM -1.06114117881454 0.131958391104083 no 2922 0.144312873133948 4047 1272339 YGL099W LSG1 SGTC_422 cantharidin 155 µM -1.06406871743935 0.131301910429126 no 2923 0.143648785470394 4068 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1376 2910-0861 41.3 µM -1.06500671443097 0.131092048843587 no 2924 0.14343644564546 4088 1112859 SGTC_2338 7999974 200 µM -1.06561252428647 0.130956631951414 no 2925 0.143299417637399 4162 315925 SGTC_2980 9014342 25.29 µM -1.06603800856239 0.130861581102602 no 2926 0.143203230300925 4220 2996599 SGTC_3247 9135149 49.47 µM -1.06830303309351 0.130356389620138 no 2927 0.142691920380327 4175 8934436 YOR116C RPO31 SGTC_2618 avocadyne 43.43 µM -1.07267513034096 0.129385055534187 no 2928 0.141708451261291 4074 3015189 SGTC_2098 5376439 882.5 nM -1.07506982192115 0.128855166141716 no 2929 0.141171734676072 4207 2844116 SGTC_3273 9137859 49.47 µM -1.0759606202522 0.128658437908123 no 2930 0.140972434315098 4240 2377234 SGTC_2256 7954252 200 µM -1.07609615486022 0.128628524063535 no 2931 0.140942127580891 4178 2972920 SGTC_363 0455-0021 3.06 µM -1.07832087210689 0.128138196426823 no 2932 0.140445292811191 4128 4597466 SGTC_2600 tangeritin 87.95 µM -1.08206375217299 0.127316198072333 no 2933 0.139612100472944 4110 68077 A bioactive flavone. SGTC_765 1319-0117 244 µM -1.08432828810457 0.126820653183132 no 2934 0.139109633543854 4142 3487746 YGL099W LSG1 SGTC_2330 7979373 200 µM -1.08504096422845 0.126664977547139 no 2935 0.13895175623985 4129 1863007 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.08558068208664 0.126547171180078 no 2936 0.138832275140348 4153 6312947 SGTC_2228 7354201 200 µM -1.08558505110356 0.126546217848861 no 2937 0.138831308226219 4233 753451 SGTC_868 0527-0199 213 µM -1.08645236856527 0.126357065913043 no 2938 0.138639451625012 4138 2849450 SGTC_701 4424-0219 185 µM -1.09123897993081 0.125316705329026 no 2939 0.137583870004034 4241 2911779 SGTC_1302 1159-0335 255 µM -1.09131704981481 0.125299786701783 no 2940 0.137566699002766 4192 649284 SGTC_1762 st045503 25.4615 µM -1.09199367417274 0.125153221347895 no 2941 0.137417940826121 4269 4645554 SGTC_2679 rapamycin 1 nM -1.09257198310493 0.125028047279084 no 2942 0.137290884717219 4098 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_747 3448-8087 38.7 µM -1.09277754451406 0.124983574904961 no 2943 0.137245741627589 4229 5168703 SGTC_3229 9132204 49.47 µM -1.09402404086002 0.124714137157875 no 2944 0.136972217235117 4250 17682924 SGTC_2626 ethyl orsellinate 100 µM -1.09418704389244 0.124678933099933 no 2945 0.136936476295402 4161 75653 A natural product. SGTC_1742 st038235 28.8875 µM -1.0942563701834 0.1246639626816 no 2946 0.136921277364226 4241 564103 YBR002C RER2 SGTC_2206 7254556 146.969 µM -1.095013909035 0.12450046052863 no 2947 0.13675527147709 4189 4398905 SGTC_806 3966-4455 5.86 µM -1.09900308497543 0.123641936995715 no 2948 0.1358833601429 4168 714982 SGTC_162 k030-0015 37.8 µM -1.09908547016362 0.123624250410775 no 2949 0.135865393480161 4262 1809920 YMR134W ERG29 SGTC_904 1141-0088 396 µM -1.09926343319624 0.123586051067404 no 2950 0.135826588636469 4191 1378119 SGTC_677 0929-0063 136 µM -1.10342091346816 0.122696009227138 no 2951 0.134922209388362 4178 1539583 SGTC_742 0kpi-0133 140 µM -1.1040236147326 0.122567355802264 no 2952 0.134791447017851 4232 2728852 SGTC_2033 5192550 145 µM -1.11163909789937 0.12094989439179 no 2953 0.133146677452264 4210 182073 SGTC_1546 5-methoxyflavanone 78.7 µM -1.11194195251111 0.120885882739741 no 2954 0.133081554618104 4203 147795 SGTC_960 1222-0186 7.7 µM -1.11299904362802 0.120662641756173 no 2955 0.132854420116796 4236 3126296 SGTC_1914 st062367 72.6 µM -1.1136108731665 0.120533565685495 no 2956 0.132723079875603 4200 978205 SGTC_82 0054-0107 293.755 µM -1.11884608483905 0.119433081395116 no 2957 0.131602903650664 4165 3104697 SGTC_696 1560-0013 611 µM -1.12444632600401 0.118263733654016 no 2958 0.130411864262924 4269 1650269 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.12468041526752 0.118215031963469 no 2959 0.130362241850715 4275 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1079 idarubicin 2.36 µM -1.1255873124832 0.118026488149038 no 2960 0.130170120445622 4229 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1766 st045414 44.774 µM -1.12617223997284 0.117904994694879 no 2961 0.130046310619807 4231 253960 SGTC_1381 2324-0066 62.1 µM -1.1270859611662 0.117715385643011 no 2962 0.129853069178968 4267 10885928 SGTC_2243 6634756 200 µM -1.13258565575344 0.116578685561463 no 2963 0.128694147600044 4280 885676 SGTC_1680 diphenhydramine 100 µM -1.13342696135297 0.116405489768645 no 2964 0.128517498585026 4211 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_200 k038-0079 37.545 µM -1.13480157760081 0.116122896634365 no 2965 0.128229232551906 4192 3436683 SGTC_2984 9022109 38.96 µM -1.13558031933135 0.115963019406951 no 2966 0.128066124695047 4255 6459207 SGTC_2621 lithochol-11-enic acid 100 µM -1.13656874726997 0.115760318325607 no 2967 0.127859305585095 4182 6708711 SGTC_991 3996-0057 64.7 µM -1.13951740569407 0.11515711997742 no 2968 0.127243706370483 4287 715343 SGTC_1686 st019653 115.5 µM -1.14012632932732 0.115032833162767 no 2969 0.127116837074696 4222 97252 SGTC_2794 7785382 27.27 µM -1.14229072200844 0.114591833281349 no 2970 0.126666598251334 4220 2205081 SGTC_2145 5634607 200 µM -1.1425340740875 0.114542325096973 no 2971 0.126616045483231 4203 308662 SGTC_2722 naftopidil 47.16 µM -1.14340709323941 0.114364841074325 no 2972 0.126434804400717 4170 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_129 0088-0017 176.636 µM -1.14686927151076 0.113662911473691 no 2973 0.125717827142531 4117 182446 SGTC_2531 methyl deoxycholate 70.07 µM -1.14788082861976 0.113458407129945 no 2974 0.125508881770019 4187 16667744 Haematoxylin. SGTC_3048 9093155 49.47 µM -1.14816337687531 0.113401331862413 no 2975 0.125450562448973 4217 25236002 SGTC_2184 6075246 200 µM -1.14844720113863 0.11334401945812 no 2976 0.125391998798503 4241 2267320 SGTC_1559 coumarin 343 70.1 µM -1.15258964200634 0.11250989010089 no 2977 0.124539428341117 4268 108770 A hepatotoxic, DNA x-linker. SGTC_779 1360-0071 233 µM -1.15413704071123 0.112199430816253 no 2978 0.124221994778035 4290 7566 SGTC_980 1473-0395 201 µM -1.15431316656617 0.112164133002708 no 2979 0.124185900205937 4127 768876 SGTC_2502 avocadyne acetate 18.59 µM -1.15554872840362 0.111916734169702 no 2980 0.123932895063078 4184 3952079 SGTC_3146 9095609 49.47 µM -1.15581972689456 0.111862523858776 no 2981 0.123877451162831 4297 17173999 SGTC_667 1498-1044 59 µM -1.15620560838727 0.111785364859791 no 2982 0.123798533179016 4250 6739982 SGTC_772 k072-0172 35.3 µM -1.15651567455401 0.111723393115677 no 2983 0.12373514596196 4293 5861980 SGTC_2513 baicalein 25.65 µM -1.15719256484674 0.111588191025149 no 2984 0.123596847383942 4255 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1355 1499-0035 1.68 µM -1.15875192056639 0.111277170840571 no 2985 0.123278660257194 4243 1548538 SGTC_2326 6164455 177.58 µM -1.16166126679588 0.110698549328085 no 2986 0.122686542463834 4206 2888790 SGTC_2956 9076196 2.52 µM -1.16364387285427 0.110305478612891 no 2987 0.122284181955069 4248 16423868 SGTC_1815 st051655 58.2 µM -1.16374177213942 0.110286095103597 no 2988 0.122264337785846 4206 5984156 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.16381797271427 0.110271009507931 no 2989 0.122248893506316 4237 16623 A steroid. SGTC_222 nsc-310342 10.666 µM -1.16585497510689 0.109868288069153 no 2990 0.121836542842209 4271 432556 SGTC_3237 9133362 49.47 µM -1.17331298479853 0.108402826630772 no 2991 0.120335158529501 4242 43845137 SGTC_714 4296-0578 26.1 µM -1.17585685300688 0.107906200630716 no 2992 0.119826041545326 4310 1589775 SGTC_2565 isoliquiritigenin 100 µM -1.17998397537462 0.107103973454459 no 2993 0.11900329419232 4347 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_274 sirtinol 40.1 µM -1.18000829716493 0.107099258585054 no 2994 0.118998457463178 4321 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1594 piperine 70.1 µM -1.18187386577806 0.106738057139533 no 2995 0.118627876562216 4247 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1755 st041960 45.185 µM -1.18271763739414 0.10657497961686 no 2996 0.118460535885067 4304 2257073 SGTC_3065 9113888 49.47 µM -1.1840198973652 0.106323642208187 no 2997 0.118202593267237 4323 16648368 SGTC_1291 0993-0025 5.79 µM -1.18461843915372 0.106208266771307 no 2998 0.118084171580428 4273 4353356 SGTC_2556 citropten 84.59 µM -1.18535591372366 0.106066234922437 no 2999 0.117938377418377 4304 2775 A potential DNA crosslinker. SGTC_3246 9135460 32.98 µM -1.18689323810586 0.105770599553317 no 3000 0.11763486742949 4248 41446951 SGTC_786 4544-0069 423 µM -1.18707888217046 0.105734939595586 no 3001 0.11759825364763 4261 748821 YLR208W SEC13 SGTC_177 1327-0068 8.361 µM -1.18744196662173 0.105665220630785 no 3002 0.117526667379712 4262 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2006 4011487 200 µM -1.18745787917407 0.105662165885344 no 3003 0.117523530743171 4286 45595294 SGTC_1879 gemcitabine 100 µM -1.1888615078377 0.105392961335039 no 3004 0.11724708465099 4248 60750 A nucleoside analog which inhibits DNA replication. SGTC_2240 6690706 185.951 µM -1.19811611329722 0.103630416237112 no 3005 0.115435908346753 4166 805876 SGTC_2078 5212016 200 µM -1.19849333016194 0.103559031473566 no 3006 0.115362509030049 4175 1899708 SGTC_1656 st012921 11 µM -1.19937334177673 0.103392636250882 no 3007 0.115191404267591 4181 6732821 SGTC_1572 epiandrosterone 68.9 µM -1.19961230943696 0.103347485057382 no 3008 0.115144971835689 4208 441302 A steroid. SGTC_3072 9116419 49.47 µM -1.2014717215285 0.102996651664903 no 3009 0.114784134738623 4324 17170162 SGTC_1145 3546-0597 10.2 µM -1.20296175084987 0.102716138350316 no 3010 0.114495561173523 4253 875334 SGTC_1479 0549-0158 134 µM -1.2037635161402 0.102565427767688 no 3011 0.11434049738447 4353 5440202 SGTC_783 0848-0141 92.7 µM -1.20507852931274 0.10231858837343 no 3012 0.11408649377918 4213 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2712 st079126 47.7 µM -1.20508766740785 0.102316874586514 no 3013 0.114084730102273 4270 3152970 SGTC_122 0236-0016 402.397 µM -1.20586757765944 0.102170684695928 no 3014 0.113934276886072 4277 6808838 SGTC_298 1391-0729 10 µM -1.20630664713283 0.102088450417451 no 3015 0.113849637809042 4226 3237558 SGTC_3051 9093778 49.47 µM -1.20646058746041 0.102059630002873 no 3016 0.113819973464763 4360 17217378 SGTC_470 aa-861 153 µM -1.20932358241049 0.101524704015808 no 3017 0.113269277141165 4243 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_838 0109-0203 71.4 µM -1.21566742769447 0.100346692055299 no 3018 0.112055818483983 4325 759422 SGTC_2529 gangaleoidin 93.61 µM -1.21583015876519 0.100316605704124 no 3019 0.112024813813044 4309 4565183 SGTC_1915 st067105 30.6 µM -1.21622076466189 0.100244415839696 no 3020 0.111950417854263 4237 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1611 st001856 99.4 µM -1.21643493042032 0.10020485087414 no 3021 0.111909642206336 4266 647478 SGTC_2649 anisomycin 9.56 µM -1.2170340610982 0.100094228071002 no 3022 0.111795628372351 4343 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_972 1319-0219 195 µM -1.22159636648642 0.099254772704769 no 3023 0.11093015168743 4288 23903702 SGTC_1616 st002734 56.1 µM -1.22171825737719 0.099232415835165 no 3024 0.110907094801128 4242 4026101 SGTC_1247 0448-0043 5.84 µM -1.22281336160458 0.0990317201653971 no 3025 0.110700098803178 4312 3089013 YGL099W LSG1 SGTC_3161 9100388 49.47 µM -1.22615646962134 0.0984208781783285 no 3026 0.110069899425212 4388 25236368 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.22877309219068 0.0979447055076178 no 3027 0.109578446387242 4308 1377 SGTC_3296 9122258 64.045 µM -1.22918218612392 0.0978704115174908 no 3028 0.109501753171938 4277 4730474 SGTC_942 3253-1115 227 µM -1.22966467894766 0.0977828409310825 no 3029 0.109411349351217 4335 46497897 SGTC_2012 4023501 200 µM -1.22992965617489 0.0977347730275982 no 3030 0.109361723850998 4324 3477460 SGTC_1501 4491-0275 38.4 µM -1.23313958933573 0.0971538540694087 no 3031 0.108761844640669 4294 5104718 SGTC_709 3807-1509 243 µM -1.23440624744898 0.0969253187094035 no 3032 0.108525781102351 4373 1886677 YPL242C IQG1 SGTC_1065 prochlorperazine maleate 2.48 µM -1.23529695737598 0.0967648498897771 no 3033 0.108360002851067 4352 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2173 5763948 167 µM -1.23591419180882 0.0966537644608604 no 3034 0.108245230591315 4292 2867177 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.23934940985629 0.0960372295125433 no 3035 0.107608063983674 4341 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3274 9138298 49.47 µM -1.23977157827327 0.0959616609150508 no 3036 0.107529946750452 4294 17015756 SGTC_1352 1496-0991 99 µM -1.24020002152938 0.0958850138325214 no 3037 0.107450710224108 4313 3000039 SGTC_912 3474-0017 2.18 µM -1.24475704330581 0.0950725625262635 no 3038 0.106610535348468 4354 3360550 SGTC_586 0957-0265 8.15 µM -1.24771778091324 0.0945474299023288 no 3039 0.106067213681468 4190 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2371 9071574 200 µM -1.24857094483646 0.0943965056909814 no 3040 0.105911022463936 4335 45596039 SGTC_1889 st059080 5.18 µM -1.25291551442022 0.0936307088665074 no 3041 0.105118227548091 4299 176925 Isolated from Daphnopsis sellowiana. SGTC_296 1222-0039 74.9 µM -1.25309484635144 0.0935991977460746 no 3042 0.105085595694038 4339 5984176 SGTC_2893 9048488 25.97 µM -1.25319858725314 0.0935809725991305 no 3043 0.105066721990974 4368 6467338 SGTC_1524 corynanthine 62.1 µM -1.26030976701154 0.0923379225009525 no 3044 0.103778818988377 4414 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1490 4089-0339 670 nM -1.26094060644337 0.0922282432625365 no 3045 0.103665123364712 4310 742542 SGTC_307 1501-1223 22.3 µM -1.2626104210698 0.0919383908268914 no 3046 0.103364610456409 4369 2830329 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.26615285709625 0.0913257166665831 no 3047 0.102729180905883 4362 94937 An inhibitor of serotonin biosynthesis. SGTC_3345 9148410 3.559 µM -1.26809881353478 0.0909904487970349 no 3048 0.102381332594314 4281 4903596 SGTC_317 4495-0002 170 µM -1.27362018691219 0.0900441455621358 no 3049 0.101399027229627 4369 15991618 SGTC_1888 azatryptophan 97.5 µM -1.27415666481984 0.0899525903160462 no 3050 0.101303949858214 4391 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1434 4073-0095 163 µM -1.27449607664166 0.0898947020808898 no 3051 0.101243831106349 4335 24133745 SGTC_2180 6301957 200 µM -1.27575983484484 0.0896794058105519 no 3052 0.101020214922297 4371 845462 SGTC_1300 1094-0077 113 µM -1.27881922349758 0.0891597902799211 no 3053 0.100480361409209 4304 5532636 SGTC_613 3914-0030 117 µM -1.2803388396075 0.0889025285401499 no 3054 0.100212996800697 4062 1145395 SGTC_2826 7992541 19.48 µM -1.28106192807611 0.0887803082950834 no 3055 0.100085957521703 4355 2985066 SGTC_2378 9074213 121.43 µM -1.28145632233013 0.0887136984433054 no 3056 0.100016716045394 4315 657714 SGTC_2349 9023730 187.07 µM -1.28231146651977 0.0885693996766258 no 3057 0.0998667035753044 4394 4126287 SGTC_2811 7967822 32.47 µM -1.28512460751512 0.0880959381976442 no 3058 0.0993743719073826 4386 2232244 SGTC_2053 5265679 138 µM -1.28676582428097 0.0878205886259359 no 3059 0.0990879611007209 4258 764595 SGTC_2822 7994718 71.43 µM -1.28916522027394 0.0874191940870563 no 3060 0.09867032672663 4342 1018011 SGTC_119 0121-0043 24.815 µM -1.28920700733037 0.0874122156899734 no 3061 0.0986630647817287 4369 1092378 SGTC_2258 7960471 200 µM -1.29739528150343 0.0860527915335701 no 3062 0.0972476076039032 4366 2974708 SGTC_2934 9036370 36.88 µM -1.30119228182573 0.0854278048517296 no 3063 0.0965963232386843 4346 6462800 SGTC_1057 3448-5381 134 µM -1.3028513001494 0.0851557999781155 no 3064 0.0963127664234484 4347 5497911 SGTC_657 3534-0529 86.7 µM -1.30289808269042 0.0851481391512346 no 3065 0.0963047793028892 4400 1049549 SGTC_174 3553-0389 74.3 µM -1.31010191347797 0.0839746361143009 no 3066 0.0950806806112433 4425 738071 SGTC_233 rapamycin 362 pM -1.31089418392208 0.0838463202684216 no 3067 0.0949467580514247 4362 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2403 6032726 181.2 µM -1.31182413325693 0.0836958939326325 no 3068 0.0947897400939965 4404 2881040 SGTC_2414 st077232 92.9 µM -1.3122922241144 0.0836202534498692 no 3069 0.0947107773964326 4308 729801 SGTC_1165 k072-0275 30.3 µM -1.31527344100685 0.0831397127466574 no 3070 0.0942090103708977 4349 6153523 YGL055W OLE1 SGTC_3290 9121031 71.43 µM -1.31563952078607 0.0830808479963707 no 3071 0.0941475311110326 4377 17014854 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.31577250357038 0.0830594724465371 no 3072 0.0941252053773344 4396 6728940 SGTC_3075 9116269 49.47 µM -1.31628482339844 0.0829771612149524 no 3073 0.0940392313839988 4386 17015205 YNL244C SUI1 SGTC_2352 9027995 87.8 µM -1.32597954283614 0.0814311150993094 no 3074 0.0924232367935372 4342 2997347 SGTC_1157 4092-0394 27.6 µM -1.32652011273742 0.0813455526249679 no 3075 0.0923337388069341 4440 3659885 SGTC_215 1287-0124 461.5 µM -1.32880073699631 0.0809853173875322 no 3076 0.0919568594935927 4400 5560863 SGTC_1208 2323-2347 50.3 µM -1.32895507819694 0.0809609820464837 no 3077 0.0919313954102978 4393 5412760 SGTC_2582 agaric acid 100 µM -1.33002309131164 0.0807927371296297 no 3078 0.091755331652588 3992 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2786 7743617 45.45 µM -1.33034773541132 0.0807416480525041 no 3079 0.0917018630637145 4322 583674 SGTC_1845 st056753 3.01 µM -1.33620912899815 0.0798234348922689 no 3080 0.0907404640218763 4362 5375839 SGTC_2017 5132927 60.65 µM -1.34241513427247 0.0788598678257342 no 3081 0.0897307151446623 4379 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1943 st076331 65.2 µM -1.34385223275133 0.0786380003684342 no 3082 0.089498087541637 4393 24208415 SGTC_123 0083-0120 66.675 µM -1.34759411007436 0.0780625278117513 no 3083 0.0888944830094998 4386 16001701 SGTC_1155 4088-0394 48.2 µM -1.3545428517237 0.0770023471787971 no 3084 0.0877816258866393 4394 2326248 SGTC_2581 avocatin a 64 µM -1.3546959420182 0.0769791137705544 no 3085 0.0877572256575824 4345 6710728 A skin care supplement. SGTC_2458 5808907 16.39 µM -1.35582724844785 0.0768075887072174 no 3086 0.0875770697026619 4534 2731747 SGTC_473 2-arachidonoylglycerol 10 µM -1.36904787238364 0.0748246047508322 no 3087 0.085492155553246 4242 5282280 An endocannabinoid. SGTC_1502 4534-4282 27.7 µM -1.36954156615167 0.074751318505705 no 3088 0.0854150255089864 4390 3278949 SGTC_1700 st030840 7.9285 µM -1.36999663282421 0.0746838147716184 no 3089 0.0853439763709511 4450 5499307 SGTC_2528 xanthyletin 44.79 µM -1.3711348375926 0.0745151793111569 no 3090 0.0851664633732853 4445 65188 An natural product with antifungal activity of unknown mechanism. SGTC_814 3342-0569 96 µM -1.3775454843926 0.0735708074721501 no 3091 0.0841718311944051 4448 4346283 SGTC_227 fluconazole 33.516 µM -1.37922081790608 0.0733255237076988 no 3092 0.0839133406658347 4418 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2635 hydroquinidine 100 µM -1.39616118080062 0.0708803289405171 no 3093 0.0813329817813857 4362 442912 An experimental heart treatment. SGTC_989 1501-0895 10.3 µM -1.39657477051585 0.0708214239031283 no 3094 0.0812707407675878 4413 2830112 SGTC_592 k241-0073 46.5 µM -1.40216461368384 0.0700289815912306 no 3095 0.080433047958755 4462 4230158 SGTC_986 1493-0483 84 µM -1.40442423672999 0.0697105898646994 no 3096 0.0800962789249678 4389 40079 SGTC_1772 st048439 82.2 µM -1.40755833415821 0.0692708266399042 no 3097 0.0796309462270541 4476 2927068 YDL195W SEC31 SGTC_1865 st057639 52.2 µM -1.40765757330475 0.0692569368133745 no 3098 0.0796162452501118 4432 688818 SGTC_1685 st024049 53.0905 µM -1.40824947970593 0.0691741362712579 no 3099 0.0795286047316075 4452 1941139 SGTC_1323 1348-1351 11.2 µM -1.41395165327179 0.0683803733977748 no 3100 0.0786880491215168 4429 6989654 SGTC_1587 estradiol valerate 56.1 µM -1.41505498926614 0.0682275997855147 no 3101 0.0785261869328235 4487 13791 A steroid. SGTC_1874 staurosporine 7.6 µM -1.41600565375375 0.0680961772525066 no 3102 0.0783869245695261 4450 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.41653475868773 0.068023116996526 no 3103 0.078309497410944 4473 66535 A nucleotide analog. SGTC_3279 9140807 49.47 µM -1.41909918548309 0.0676698711288605 no 3104 0.0779350506915697 4495 45595718 SGTC_2183 6420625 130.508 µM -1.42021835747689 0.0675161518145122 no 3105 0.0777720604378816 4482 2897619 SGTC_3268 9137683 49.47 µM -1.42146783896598 0.0673448533187618 no 3106 0.0775903984204218 4510 1953228 SGTC_2368 9071271 200 µM -1.42173128115026 0.0673087794574643 no 3107 0.0775521377401317 4419 27209959 SGTC_2793 7325131 81.82 µM -1.42200373479207 0.0672714873473009 no 3108 0.0775125833637433 4385 4176441 SGTC_309 k408-0051 1.48 µM -1.42220183609146 0.0672443822497936 no 3109 0.0774838329598603 4377 3640463 SGTC_2001 4023502 57.655 µM -1.42558117030716 0.0667833062182722 no 3110 0.0769946373445839 4457 108941 YCR052W RSC6 SGTC_353 1988-1175 58.3 µM -1.42774222838001 0.0664897364695784 no 3111 0.0766830333618855 4272 2788357 SGTC_1265 0819-1001 68.8 µM -1.42969628305682 0.0662251481625046 no 3112 0.0764021037656251 4399 3106768 SGTC_1114 scopoletin 1.73284 µM -1.42984700312413 0.0662047738720981 no 3113 0.0763804676865341 4476 5280460 A coumarin with genotoxic properties. SGTC_2760 etidronate 98.04 µM -1.43178986234145 0.0659425732439116 no 3114 0.0761019847110482 4403 3305 A chelator and antioxidant. SGTC_303 1348-1668 34.2 µM -1.43481082294318 0.0655364755729339 no 3115 0.0756705064749603 4462 5380509 SGTC_3239 9133757 49.47 µM -1.43563023744369 0.0654266594503193 no 3116 0.0755537929330703 4518 17036923 SGTC_1419 3993-2473 62.6 µM -1.43582421299549 0.0654006841786822 no 3117 0.0755261840584472 4526 704026 SGTC_2872 9044037 25.97 µM -1.43772069447396 0.0651471475132918 no 3118 0.0752566594549505 4502 6465195 SGTC_3300 9124615 50.48 µM -1.4416403017586 0.0646255611477168 no 3119 0.0747019364325685 4488 24824903 SGTC_2710 st078562 53.7235 µM -1.44280310511942 0.0644714511294181 no 3120 0.0745379721088802 4422 17250908 SGTC_832 4083-0019 164 µM -1.44350123137068 0.0643790635031154 no 3121 0.0744396629337776 4540 1990758 SGTC_2680 butyl paraben 22.24 µM -1.44424189207086 0.0642811595153644 no 3122 0.0743354723691996 4545 7184 An antifungal and steroid mimetic. SGTC_1172 0370-0043 85 µM -1.44972454059473 0.0635600319986484 no 3123 0.0735676747413736 4488 376585 SGTC_3198 9112019 49.47 µM -1.45397078490729 0.0630058658517356 no 3124 0.0729772030695663 4512 45595555 SGTC_2429 5902844 64.44 µM -1.45485286835645 0.0628912209778019 no 3125 0.072854999129703 4453 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_378 3970-0959 8.33 µM -1.45506172036283 0.0628641001776103 no 3126 0.072826087700176 4482 6615653 SGTC_1925 st057770 10.1 µM -1.45602840614403 0.0627386883816693 no 3127 0.0726923835806244 4471 5989122 SGTC_310 1273-0058 1.06 µM -1.45832739000172 0.0624412157787228 no 3128 0.0723751620057241 4208 2734232 SGTC_1439 4092-1168 46 µM -1.45855803980113 0.0624114320951836 no 3129 0.0723433948018366 4474 2886240 SGTC_2408 sulbentine 18.36 µM -1.45877514618009 0.0623834073882761 no 3130 0.0723135026844439 4352 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1486 3970-0793 4.53 µM -1.4696829775993 0.0609879845829953 no 3131 0.0708238175548108 4507 2844330 SGTC_2224 6650123 117.647 µM -1.47071953144244 0.0608566595392851 no 3132 0.0706834909591428 4503 2908370 SGTC_2961 9083290 32.55 µM -1.47158640447048 0.060747001888588 no 3133 0.0705662995595711 4441 17741490 SGTC_1279 0874-0590 65.2 µM -1.47416741229093 0.0604214245708959 no 3134 0.0702182608084136 4539 3523074 SGTC_2867 9039098 71.43 µM -1.47625754367095 0.0601587700584617 no 3135 0.0699373834976347 4459 6463460 SGTC_823 0417-1665 178 µM -1.47835744584901 0.0598957887118274 no 3136 0.0696560645676826 4508 3429856 SGTC_35 0133-0054 64.071 µM -1.48016954243516 0.0596695752452093 no 3137 0.0694140032251409 4451 99677 SGTC_2074 5212007 75.395 µM -1.48222004311726 0.0594144085093933 no 3138 0.0691408775749602 4405 758611 SGTC_1468 k284-1086 134 µM -1.4835567668832 0.0592485261344363 no 3139 0.0689632730171469 4491 15996457 SGTC_155 k072-0202 43.6 µM -1.48383571515801 0.0592139555507883 no 3140 0.0689262547842383 4469 5857737 SGTC_2857 9024691 58.44 µM -1.49030867201944 0.0584161839469125 no 3141 0.0680715466721453 4508 16478292 SGTC_573 3702-0553 84.7 µM -1.4909865574207 0.0583331273178702 no 3142 0.067982512114411 4436 1222756 SGTC_1727 st034309 9.9045 µM -1.49358867245635 0.0580151691790244 no 3143 0.067641580975347 4499 870305 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.4973558516472 0.0575572645123706 no 3144 0.0671503446483159 4486 688751 SGTC_859 0439-0102 54.6 µM -1.49837796672482 0.0574335168765636 no 3145 0.0670175388036708 4540 610143 SGTC_3053 9095903 49.47 µM -1.50081522463135 0.0571392822850559 no 3146 0.0667016798772474 4605 17174018 SGTC_928 2764-0428 58.7 µM -1.5054890487078 0.0565783617858611 no 3147 0.0660991951501673 4516 662578 SGTC_1235 benzylparaben 21.5 µM -1.50731583064418 0.0563603067477826 no 3148 0.0658648608611866 4530 7180 SGTC_2557 derrustone 83.84 µM -1.51338579599328 0.0556405158286733 no 3149 0.065090845422937 4474 629853 An antioxidant. SGTC_1312 1218-2183 165 µM -1.51698070144055 0.0552176564183091 no 3150 0.0646357782710748 4545 6744073 SGTC_2247 cerulenin 830 nM -1.51848067131242 0.0550419711111434 no 3151 0.0644466342630251 4519 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1221 2958-7315 257 µM -1.52207299407053 0.0546230124958201 no 3152 0.0639953959419975 4525 4562705 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.5222282756623 0.054604959620294 no 3153 0.0639759462666113 4508 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1649 st011737 51.3 µM -1.52954797062073 0.0537593196086123 no 3154 0.0630643282291749 4530 1761035 SGTC_3212 9128307 49.47 µM -1.53581613756272 0.053043435281256 no 3155 0.062291740341261 4414 27243542 SGTC_2868 9035608 32.47 µM -1.54111384083801 0.0524443000522235 no 3156 0.0616445409241868 4509 6462614 SGTC_543 3844-1095 191 µM -1.54164226025628 0.0523848351467131 no 3157 0.0615802750567931 4531 4230703 SGTC_1137 ixabepilone 100 µM -1.54234464474235 0.0523058762195116 no 3158 0.0614949327296565 4468 154225 A novel microtubule stabilizer. SGTC_1645 Cervolide 78 µM -1.54271700890177 0.0522640550503559 no 3159 0.0614497265815557 4536 23173 A fragrance. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.54339548503845 0.0521879219378736 no 3160 0.0613674242439641 4528 5024745 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.54408642593702 0.0521104806817565 no 3161 0.0612836983986199 4528 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_603 3794-0023 45.9 µM -1.54496048495017 0.0520126461945977 no 3162 0.0611779108258544 4553 3802260 SGTC_590 k048-0076 22.4 µM -1.54568397311124 0.0519317757209308 no 3163 0.0610904548718495 4531 6832814 SGTC_1396 3511-0007 98.6 µM -1.54897369113329 0.0515653150105301 no 3164 0.0606940222990463 4548 X1396 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.55132293783291 0.0513048795502435 no 3165 0.0604121562672896 4517 641818 YHR062C RPP1 SGTC_591 4299-0174 154 µM -1.55197614571695 0.0512326517150283 no 3166 0.0603339657191506 4561 5509088 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.55238679679246 0.0511872857987977 no 3167 0.0602848503645905 4490 97141 SGTC_1060 3448-7350 82 µM -1.55456560372889 0.0509471205934978 no 3168 0.0600247804952731 4462 570178 SGTC_2424 5537928 59.2 µM -1.55496667722806 0.0509030090364561 no 3169 0.0599770028766249 4524 5382802 SGTC_2714 st079313 56.9 µM -1.5586149729847 0.0505031507134583 no 3170 0.0595437685111713 4513 2939799 SGTC_417 st075190 100 µM -1.56175970470126 0.0501604954249157 no 3171 0.0591723038806692 4518 222757 SGTC_566 0958-0068 16.5 µM -1.5622742798369 0.0501046033032572 no 3172 0.0591116942064174 4435 6815365 SGTC_550 4123-0385 25.7 µM -1.56608081246975 0.0496926860526325 no 3173 0.0586648497213809 4551 5731123 SGTC_3099 9120367 49.47 µM -1.56817896119823 0.0494667963168207 no 3174 0.058419686457994 4560 24824940 SGTC_688 0527-0193 473 µM -1.56997898527123 0.0492736569957175 no 3175 0.0582100001652521 4566 4007154 SGTC_1575 cyproterone acetate 48 µM -1.57312137293691 0.0489379280661865 no 3176 0.0578453584454871 4519 9880 An androgen receptor antagonist and liver toxin. SGTC_1736 st036774 51 µM -1.58173437993119 0.0480270888109656 no 3177 0.056855110367855 4564 1272247 SGTC_369 0957-0393 4.5 µM -1.58188671615798 0.0480111019623207 no 3178 0.0568377169950642 4522 6997992 SGTC_419 nsc-638432 893 µM -1.58766987267836 0.0474073351215777 no 3179 0.0561805045152727 4519 368090 SGTC_170 4197-0004 226 µM -1.5895713032622 0.0472101582668563 no 3180 0.0559657349141658 4553 218692 SGTC_2261 9010538 184.68 µM -1.59694783384946 0.0464514319443297 no 3181 0.0551386679820583 4515 6457250 SGTC_1311 1190-0148 100 µM -1.59914525466831 0.0462273141923118 no 3182 0.05489416561328 4583 1961333 SGTC_2100 5377183 190 µM -1.59919778252624 0.0462219674544619 no 3183 0.0548883314529672 4565 2844202 SGTC_1628 st004252 77.7 µM -1.60005943220894 0.0461343321947455 no 3184 0.0547926997427643 4533 692968 SGTC_3335 9143315 29.6265 µM -1.60392765493322 0.045742552363951 no 3185 0.0543650000817206 4560 4899691 SGTC_1483 3453-0561 55.9 µM -1.61185033038543 0.0449484794309346 no 3186 0.0534972564256261 4579 4546991 SGTC_2540 epiandrosterone 100 µM -1.61301690634661 0.0448324988821109 no 3187 0.0533704174112636 4574 441302 A steroid. SGTC_2903 5923464 63.88 µM -1.61391066158654 0.0447438051827312 no 3188 0.0532734028788557 4569 2876576 SGTC_3181 9108277 49.47 µM -1.61484831571892 0.0446509070192298 no 3189 0.0531717735553027 4531 17097298 SGTC_3172 9105863 49.47 µM -1.61821277324188 0.0443188511600892 no 3190 0.05280837552182 4646 2348785 SGTC_906 1165-0455 526 µM -1.61891276197633 0.0442500163473691 no 3191 0.0527330173007086 4541 3252859 SGTC_1498 4478-3555 97.6 µM -1.61902373084494 0.0442391119161609 no 3192 0.0527210786383044 4562 3437919 SGTC_2194 5927483 104.545 µM -1.62789883656061 0.0433739839024216 no 3193 0.0517731690839442 4591 760979 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.62830443065193 0.04333477609504 no 3194 0.0517301752418701 4624 5357218 A potent inhibitor of glutathione S-transferases. SGTC_625 k213-0058 121 µM -1.62850634832176 0.0433152678705856 no 3195 0.0517087821202106 4620 3655420 SGTC_2992 9074591 71.4286 µM -1.62910828088463 0.043257154384797 no 3196 0.0516450492608628 4495 17741321 SGTC_3077 9117319 49.47 µM -1.63080982391384 0.0430932196701907 no 3197 0.051465226951516 4520 17154678 SGTC_2674 ligustilide 100 µM -1.63223641359619 0.042956162363401 no 3198 0.0513148462931906 4608 5319022 A signalling regulator. SGTC_2790 5423970 71.43 µM -1.63992576134392 0.042223474919673 no 3199 0.0505103018759515 4565 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_26 0302-0163 425.158 µM -1.64341875398616 0.0418939982026034 no 3200 0.0501481612643978 4626 3100915 SGTC_843 0310-0051 143 µM -1.64503086838617 0.0417426390647395 no 3201 0.0499817227555956 4578 2065037 SGTC_475 α-linolenic acid 10 µM -1.64562665860002 0.0416868133734574 no 3202 0.0499203235598186 4561 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3070 9117005 49.47 µM -1.64713707250824 0.0415455581677746 no 3203 0.0497649373010001 4660 8779016 SGTC_1358 1509-0022 2.48 µM -1.64793894429291 0.0414707241668778 no 3204 0.0496826003905516 4591 3258434 SGTC_1281 0884-0031 11.8 µM -1.64849038099699 0.041419325219067 no 3205 0.0496260414798014 4568 1548255 SGTC_2214 7179297 48.276 µM -1.65209128293994 0.0410849561867731 no 3206 0.0492579718558987 4629 769744 SGTC_1839 st053978 48 µM -1.65714947339567 0.040618968096877 no 3207 0.0487446294387646 4596 3788398 SGTC_1986 st071812 45 µM -1.66144998682287 0.0402261636976516 no 3208 0.0483115527957776 4525 11838594 SGTC_2939 9044578 71.43 µM -1.66511330954005 0.0398939983230412 no 3209 0.0479450759309391 4501 2653634 SGTC_260 nsc-65238 3.989 µM -1.66560548485617 0.0398495415554946 no 3210 0.0478960089898535 4564 3246252 SGTC_2404 5161160 200 µM -1.67887171459775 0.0386663361724491 no 3211 0.0465885240987032 4531 2831543 SGTC_2653 dihydrofissinolide 100 µM -1.67963113343263 0.0385994797082674 no 3212 0.0465145531605943 4654 6857746 SGTC_3184 9108758 49.47 µM -1.68643224419899 0.0380049246686037 no 3213 0.0458562876300562 4626 902885 SGTC_1682 st012968 530 nM -1.68777824714288 0.0378881469163286 no 3214 0.0457269023980932 4559 24207270 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.68983797562698 0.037710014111052 no 3215 0.0455294781760395 4530 6708739 YPR165W RHO1 SGTC_1021 4476-0760 85.3 µM -1.69179742858291 0.0375411885997044 no 3216 0.0453423020315865 4605 746768 SGTC_1937 st074714 47.2 µM -1.69498526840534 0.0372678450784113 no 3217 0.0450391077107795 4520 17250970 SGTC_582 0987-0078 156 µM -1.6992669646704 0.0369032689947854 no 3218 0.0446344470225906 4625 1625765 SGTC_493 zm226600 134 µM -1.70054010118376 0.0367954286582678 no 3219 0.044514690055594 4585 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2816 7982706 58.44 µM -1.70773714314926 0.0361906434608388 no 3220 0.0438425634412932 4571 2981853 SGTC_571 k831-0106 44.2 µM -1.71064615434443 0.0359485129766799 no 3221 0.0435732266509702 4488 4783639 SGTC_275 trichlorophene 5.69 µM -1.7150708208149 0.0355827730676287 no 3222 0.0431661216557069 4620 62616 SGTC_1321 1326-2144 215 µM -1.71589514255042 0.0355149734247941 no 3223 0.0430906179678377 4577 3513030 SGTC_2291 7917025 104.35 µM -1.71942743125369 0.0352256445116489 no 3224 0.0427682854650286 4493 2964612 SGTC_3307 9126885 69.2785 µM -1.72924359887253 0.034431744487038 no 3225 0.0418827531345818 4574 24824909 SGTC_1005 4092-0690 4.4 µM -1.73536695826981 0.0339439951876854 no 3226 0.0413379143462182 4607 1529343 SGTC_2444 5485484 36.41 µM -1.74295272288655 0.0333476549519846 no 3227 0.0406709366950589 4634 6790631 SGTC_600 1495-0418 41.6 µM -1.75304129234055 0.0325679547314289 no 3228 0.039797459746873 4600 5377768 SGTC_1884 5633444 25 µM -1.75689978534691 0.0322737520015398 no 3229 0.0394674461242453 4550 5724239 SGTC_78 0336-0123 156.75 µM -1.76093574212021 0.0319683685632586 no 3230 0.0391246397746787 4493 6765896 SGTC_2706 st078239 82.5 µM -1.76241470350552 0.0318570610807079 no 3231 0.038999628089184 4593 15434492 SGTC_949 1165-0505 146 µM -1.76351408139033 0.0317745288580168 no 3232 0.0389069122254294 4597 6244267 SGTC_978 1416-0512 87.4 µM -1.76626079137451 0.0315691002876307 no 3233 0.038676053162972 4633 6814003 SGTC_2293 7624732 200 µM -1.77160056399994 0.031172875694692 no 3234 0.0382304430085328 4520 894453 SGTC_2266 7929956 200 µM -1.77182908266884 0.0311560112426404 no 3235 0.0382114666736036 4581 2967153 SGTC_2058 5236698 133 µM -1.77300853426569 0.0310690888416119 no 3236 0.0381136463624866 4591 766665 SGTC_812 4251-0442 148 µM -1.77459501565572 0.0309524859917662 no 3237 0.0379823904163673 4636 5723007 SGTC_1236 0330-0013 258 µM -1.78514064790761 0.03018657774956 no 3238 0.0371192530843518 4641 4617066 SGTC_1511 0906-3109 28.5 µM -1.78996993947949 0.029841116829761 no 3239 0.0367293720316518 4624 2882180 SGTC_1073 triclabendazole 3.09 µM -1.79034126029423 0.0298146909128456 no 3240 0.0366995335359398 4654 50248 An antihelmetic and likely tubulin inhibitor. SGTC_286 k060-0067 22.9 µM -1.80920042605401 0.028497846810898 no 3241 0.0352099357394625 4662 5985051 SGTC_2398 5228213 48.84 µM -1.82134479962695 0.0276757513017689 no 3242 0.0342772302391478 4582 80771 YMR134W ERG29 SGTC_3293 9120939 62.045 µM -1.82263543836637 0.0275895570811143 no 3243 0.0341793122627596 4625 934087 SGTC_1726 st035556 14.5795 µM -1.82898149540641 0.0271689897678753 no 3244 0.0337011901986497 4652 5919439 SGTC_2086 5274770 176.623 µM -1.83901095696267 0.0265152297919709 no 3245 0.0329567872467143 4663 689278 SGTC_1632 st005650 90 µM -1.83918864981764 0.0265037666229035 no 3246 0.0329437217626012 4642 2759605 SGTC_3286 9117135 37.221 µM -1.8404513934142 0.0264224248049371 no 3247 0.0328509970652362 4584 3438150 SGTC_2043 5101342 149 µM -1.85080931303332 0.0257630442654247 no 3248 0.0320984953996248 4657 678451 SGTC_2470 5664817 21.68 µM -1.85918005501443 0.0252402799570546 no 3249 0.0315008104579281 4702 2859561 SGTC_1583 clindamycin 39.6 µM -1.87178791018704 0.0244696971875257 no 3250 0.0306179757645459 4646 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_348 k064-0012 10.7 µM -1.87453329433544 0.0243045457355245 no 3251 0.0304284787589774 4629 5066323 SGTC_214 4373-3496 70 µM -1.87549393710534 0.0242469787621646 no 3252 0.0303624014009924 4691 3779166 SGTC_2709 st078560 56 µM -1.88189348096278 0.0238663983388436 no 3253 0.0299252398749931 4624 17250903 SGTC_861 0443-0273 110 µM -1.88305499665766 0.0237978642639256 no 3254 0.0298464575992374 4650 6149169 SGTC_2472 5377652 49.4 µM -1.90197520752134 0.022704590753398 no 3255 0.0285871979418848 4681 1610903 SGTC_944 3370-0224 231 µM -1.91342002558964 0.0220640494318219 no 3256 0.0278471513774847 4642 4580514 SGTC_2945 9067681 61.76 µM -1.93110298991967 0.021104397211086 no 3257 0.0267351586719738 4691 16456930 SGTC_2436 5633522 8.09 µM -1.93160680701896 0.0210775808488723 no 3258 0.0267040275219084 4651 5724242 SGTC_127 0180-0333 59.125 µM -1.93372260465212 0.0209652791455171 no 3259 0.0265736215172681 4596 771601 SGTC_1745 st081495 74 µM -1.93925406934303 0.0206740717434159 no 3260 0.0262352043506565 4541 13842402 YBL026W LSM2 SGTC_3223 9129970 49.47 µM -1.94270224527229 0.0204942794109586 no 3261 0.0260260724015336 4664 17248386 SGTC_70 0141-0289 43.283 µM -1.94632415960603 0.0203068565287543 no 3262 0.0258079066338096 4638 352408 SGTC_2222 6885208 172.143 µM -1.9514091457958 0.0200461775449077 no 3263 0.0255041971925626 4702 609514 SGTC_96 0929-0093 37.281 µM -1.9704218621259 0.0190965064151144 no 3264 0.0243950210251891 4690 6991579 SGTC_1125 tnp00248 1.32998 µM -1.97315717575722 0.0189630783901049 no 3265 0.0242388289040738 4667 24207736 SGTC_3013 9080133 71.4286 µM -1.97465676958291 0.0188902656208155 no 3266 0.0241535559839872 4700 17050193 SGTC_3309 9129340 25.759 µM -1.97746239244476 0.0187546772664763 no 3267 0.0239946937246814 4657 17158987 SGTC_1008 4106-0037 6 µM -1.97876305516755 0.0186921011731458 no 3268 0.0239213449427358 4695 2905394 SGTC_401 neomycin 50 µM -1.97997004640705 0.0186341907588178 no 3269 0.0238534472783772 4679 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1936 st074407 74.3 µM -1.98108783847839 0.0185806963274352 no 3270 0.0237907119445553 4688 809813 SGTC_2991 9074669 71.4286 µM -1.98495445336154 0.0183966580877281 no 3271 0.02357476957662 4616 17333109 SGTC_5 0352-0601 109.883 µM -1.98672187361341 0.0183130530925829 no 3272 0.023476613235827 4595 762456 SGTC_662 k832-1615 104 µM -2.00334033464855 0.0175426525670847 no 3273 0.0225703854687678 4702 5878478 SGTC_77 0828-0286 12.516 µM -2.00921240495614 0.0172771315076769 no 3274 0.0222573063542518 4592 745345 SGTC_1608 st001473 40.5 µM -2.01574572207916 0.0169857526037385 no 3275 0.0219132859479751 4676 7292267 SGTC_2774 tamoxifen 10.92 µM -2.01754623642935 0.0169061938663526 no 3276 0.0218192705072877 4672 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2417 cerulenin 830 nM -2.02024156265117 0.016787691991749 no 3277 0.0216791685208228 4680 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1806 st050005 60.3 µM -2.04004900125101 0.0159384463988497 no 3278 0.0206727227214354 4732 5194765 SGTC_668 1682-0499 62.6 µM -2.05875997044891 0.0151703105119374 no 3279 0.0197586190491772 4700 682214 SGTC_2168 5727979 200 µM -2.05877012389824 0.0151699024757555 no 3280 0.0197581324827326 4644 695210 SGTC_2023 5144124 124 µM -2.0606893536605 0.0150929436266488 no 3281 0.0196663429852035 4674 2830192 SGTC_114 0364-0001 490.298 µM -2.08297097626151 0.0142237545051887 no 3282 0.0186269345937049 4690 4003655 SGTC_1016 4226-1401 38 µM -2.11735664086423 0.0129670775799688 no 3283 0.0171147955725385 4713 2901613 SGTC_257 daunorubicin 18.5 µM -2.12204939126503 0.0128032484332742 no 3284 0.0169167953087774 4727 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_557 1315-0110 16.2 µM -2.12259802296854 0.0127842124949506 no 3285 0.0168937753889963 4695 6833801 SGTC_404 fumagillin 50 µM -2.13610662571203 0.0123231656359713 no 3286 0.016335361915943 4713 12015870 A methionine aminopeptidase binder. SGTC_1299 1079-1439 3.74 µM -2.1444608671837 0.0120453037117775 no 3287 0.0159979888725419 4716 323161 SGTC_1316 1272-0050 65.9 µM -2.14823645056031 0.0119215207405685 no 3288 0.015847488206009 4719 7340392 SGTC_1953 st076800 12.1 µM -2.15254569216179 0.0117815914333293 no 3289 0.0156772002954404 4680 297591 SGTC_413 propylparaben 100 µM -2.1538481088329 0.0117395809334679 no 3290 0.01562604274613 4708 7175 A pharmaceutical preservative. SGTC_2274 7947094 46.08 µM -2.16307100844674 0.0114457919162662 no 3291 0.0152678592691619 4700 2971028 SGTC_2446 5162541 200 µM -2.18619672301152 0.0107370662676529 no 3292 0.0144006079603716 4698 1549321 SGTC_2277 7947813 106.88 µM -2.19588387938005 0.0104517350718217 no 3293 0.0140501279307348 4717 1246798 SGTC_1014 4130-3005 69.3 µM -2.20559211123351 0.0101724357166267 no 3294 0.0137062859661028 4718 743608 SGTC_2666 tannic acid 100 µM -2.21368639249342 0.00994456828441654 no 3295 0.0134251798240091 4712 16134267 A thiamine antagonist. SGTC_2359 9039622 200 µM -2.21837253348967 0.00981469284753119 no 3296 0.0132647211442944 4702 6463596 SGTC_1807 st050092 58.9 µM -2.22035147742773 0.00976029326702061 no 3297 0.0131974590482931 4726 5008496 SGTC_3079 9117512 49.47 µM -2.22744542179684 0.00956744503083385 no 3298 0.0129587598018218 4771 7185044 SGTC_2683 piperine 63.03 µM -2.23765540708838 0.00929573676437123 no 3299 0.0126217676753897 4757 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2773 thioridazine 9.09 µM -2.23837659735104 0.00927680229451282 no 3300 0.0125982534228057 4723 5452 An antipsychotic. SGTC_2099 5377090 177.372 µM -2.24788502066211 0.00903030147475041 no 3301 0.0122917612891124 4736 2243829 SGTC_1519 esterone 74 µM -2.27044146792018 0.00846835717702257 no 3302 0.0115904054364761 4728 698 A steroid. SGTC_1055 3448-0672 86 µM -2.283562823769 0.00815578746889895 no 3303 0.0111986183679017 4709 748378 SGTC_2253 7938677 135.83 µM -2.28729534328946 0.00806874589241495 no 3304 0.0110892950588903 4749 2301972 SGTC_1185 1319-0113 81.3 µM -2.29723307298125 0.00784096899297086 no 3305 0.010802738696 4752 4672763 SGTC_792 4534-1957 155 µM -2.30927342530064 0.00757259234167773 no 3306 0.0104642066744294 4718 1717904 SGTC_3120 9124077 49.47 µM -2.31494897342792 0.00744891521420263 no 3307 0.0103078623747544 4788 18774327 YGL155W CDC43 SGTC_760 0568-0725 82.9 µM -2.32911021983439 0.00714805321790003 no 3308 0.00992661370977449 4736 3916171 SGTC_1581 himbacine 57.9 µM -2.33635772573838 0.00699826414411303 no 3309 0.00973630263495349 4756 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1623 st003709 20.3 µM -2.34611545402724 0.00680097382849629 no 3310 0.00948511511405397 4729 16192618 SGTC_2039 Aminomethylbenzodioxan 200 µM -2.34688434093815 0.00678563868702795 no 3311 0.00946556512762793 4758 15053 SGTC_3092 9117248 49.47 µM -2.35634898898883 0.00659935754854891 no 3312 0.00922778491173864 4788 17141857 SGTC_2171 5739187 198.077 µM -2.35761793083438 0.00657472940426813 no 3313 0.00919630609305384 4724 2262761 SGTC_850 0388-0143 75.9 µM -2.37286000598301 0.0062851945798935 no 3314 0.00882547627901671 4760 67273 SGTC_982 1491-0518 27.5 µM -2.37897657958714 0.0061722171236202 no 3315 0.00868038947803949 4743 3091256 SGTC_999 SEC7.066 22.7 µM -2.38797988131293 0.00600919226387798 no 3316 0.00847063458217866 4739 740511 YDR170C SEC7 SGTC_1741 st038134 10.228 µM -2.41025152783202 0.00562220352807975 no 3317 0.00797076293343712 4749 1272587 SGTC_597 k018-0003 82.8 µM -2.42822388279925 0.0053262238002159 no 3318 0.00758648685097064 4779 6786234 SGTC_536 3852-0578 10.6 µM -2.42860077814825 0.00532016805646507 no 3319 0.00757860600044774 4748 2869208 SGTC_213 1246-0773 967 nM -2.44703594805331 0.00503133586869399 no 3320 0.00720182361219041 4767 6251622 SGTC_1784 st039334 36.3 µM -2.46794610230261 0.00472069908702711 no 3321 0.00679453894517345 4751 3496984 SGTC_3097 9117246 49.47 µM -2.47115296292317 0.00467460266193802 no 3322 0.00673390990783621 4773 16423892 SGTC_735 3076-0345 636 µM -2.47478025239791 0.00462294721779678 no 3323 0.00666590884757707 4759 2888990 SGTC_430 0958-0115 16.4 µM -2.48330578245824 0.00450353740555165 no 3324 0.00650846476142236 4725 6833180 SGTC_13 0199-0087 65 µM -2.49132246187737 0.00439377513646023 no 3325 0.00636342772082875 4797 4589825 SGTC_251 melphalan 456.522 µM -2.4948909153186 0.00434569028122652 no 3326 0.00629979286773483 4774 460612 A DNA alkylator. SGTC_1184 1269-1718 139 µM -2.51451238946245 0.00408959860158982 no 3327 0.00595985571976922 4779 5403821 SGTC_3298 9116858 71.43 µM -2.52134870003976 0.00400359865796563 no 3328 0.00584529691991981 4785 2506942 SGTC_3 0833-0587 95.581 µM -2.52227975964885 0.00399201220101324 no 3329 0.0058298468820009 4683 5382644 SGTC_1679 SEC14.276 6.7 µM -2.53233823142766 0.0038687418874588 no 3330 0.00566523189767652 4717 1005053 YMR079W SEC14 SGTC_2267 7931562 200 µM -2.53481578683646 0.00383890697340538 no 3331 0.00562532360044554 4738 934880 SGTC_1808 st050063 61.5 µM -2.53576721009777 0.00382750477164813 no 3332 0.00561006460470654 4751 4011993 SGTC_3191 9110352 49.47 µM -2.53954117857028 0.00378257459492307 no 3333 0.00554989889029654 4740 17122424 SGTC_1999 st074831 12.5 µM -2.57927859746091 0.00333741054607575 no 3334 0.00495034510843311 4750 17112523 SGTC_1100 amiodarone 5.07 µM -2.60833374376387 0.00304234853152555 no 3335 0.00454920987908362 4782 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.61481615775169 0.00297981328737005 no 3336 0.00446377469181631 4776 279621 SGTC_3330 9141424 71.43 µM -2.63537163478021 0.0027891025813236 no 3337 0.0042022604087815 4767 27261020 SGTC_885 0865-0106 16.8 µM -2.63736231308369 0.00277123121089807 no 3338 0.00417767685302203 4761 2793380 SGTC_385 1494-0393 12.4 µM -2.69361448356814 0.00230706537286517 no 3339 0.00353409333718178 4774 3090647 SGTC_421 streptovitacin 30 mM -2.71869188609343 0.00212381405710136 no 3340 0.00327703140497595 4765 91467 include heat shock SGTC_1689 st020265 53.493 µM -2.72599202541864 0.00207300713920307 no 3341 0.00320542736094601 4784 5758320 YPR016C TIF6 SGTC_2030 5175110 200 µM -2.77870019801868 0.0017376954644016 no 3342 0.00272884353711931 4780 2831986 SGTC_524 r073-0010 27.8 µM -2.79725365461473 0.00163195003348432 no 3343 0.00257695266377202 4757 2772106 SGTC_2031 5180455 200 µM -2.9446314734119 0.000978738359022907 yes 3344 0.0016166976956469 4786 29949 SGTC_2364 9055074 200 µM -2.99477172187853 0.000818300611019829 yes 3345 0.00137325153085518 4769 6470630 SGTC_342 k048-0088 23.3 µM -3.00679151699659 0.000783621234979204 yes 3346 0.00132010384033304 4799 6820570 SGTC_1743 st037606 46.3785 µM -3.06931165006397 0.000624079264562254 yes 3347 0.0010727632307788 4778 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3295 9122362 53.5725 µM -3.12346332727721 0.000510726556790958 yes 3348 0.000893680687642111 4794 4730473 SGTC_1287 0971-0001 34.6 µM -3.17309369273998 0.000423884051249754 yes 3349 0.000754119217856846 4803 4665869 SGTC_2453 5731132 22.18 µM -3.1751669953853 0.000420573233439248 yes 3350 0.000748751464415995 4793 1362040 SGTC_90 0870-0863 4.608 µM -3.26057012535133 0.000303306062584049 yes 3351 0.000555942345300496 4805 1738164 SGTC_2245 6637752 200 µM -3.41206574541947 0.00016670616869069 yes 3352 0.000322362806553534 4795 681890 SGTC_2993 9054257 71.4286 µM -3.44366240258948 0.000146699831951255 yes 3353 0.000286945905245705 4781 6470217 YGL055W OLE1 SGTC_2448 5185112 27.17 µM -3.50459324638433 0.000114309412415317 yes 3354 0.000228652694976447 4800 5718189 SGTC_2244 6635614 200 µM -3.92772803465201 1.8155449094964e-05 yes 3355 4.28760507326781e-05 4800 836499 SGTC_2409 alverine citrate 63.97 µM -9.75483404098025 5.69508764658223e-25 yes 3356 8.79440614386688e-23 4809 21718 An antispasmotic used to treat irritable bowel syndrome.