SGTCid condition conc unit YJL147C|YJL147C.score YJL147C|YJL147C.strain.pval YJL147C|YJL147C.strain.significant YJL147C|YJL147C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1909 st060837 51.5 µM 8.49723881798647 3.9585800185853e-20 yes 1 9.7076860506201e-18 8 678937 SGTC_1917 st066507 28.5 µM 6.0963023583795 3.09867605955442e-11 yes 2 5.42750050937361e-10 11 3156428 SGTC_2382 9035899 200 µM 5.28562528597371 7.16870752236482e-09 yes 3 6.26380487239085e-08 5 6462679 SGTC_1386 3228-0095 33.8 µM 4.90696724795083 7.0810005907633e-08 yes 4 4.6247735717054e-07 5 870181 SGTC_2288 7946289 167.31 µM 4.4924019740545 7.23415829061605e-07 yes 5 3.52121683934398e-06 17 1246052 SGTC_1661 st013063 9.66 µM 4.31442837098614 1.85021328376688e-06 yes 6 8.00082022053089e-06 21 721395 SGTC_2391 6285546 200 µM 4.21207211770026 3.12514214016181e-06 yes 7 1.2651936217773e-05 9 846083 SGTC_80 0159-0065 512.242 µM 4.14834011727505 4.30597301310024e-06 yes 8 1.67447303630858e-05 3 1548079 SGTC_1078 idebenone 36.1 µM 4.08356893781104 5.93670090808386e-06 yes 9 2.21746322797733e-05 38 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1177 0983-0204 23.6 µM 3.71484395463295 3.38283683922843e-05 yes 10 0.000101664564746406 21 766818 SGTC_1317 1273-0028 910 nM 3.68603673621949 3.85115700218386e-05 yes 11 0.000113886743199618 61 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_789 1309-1135 70.6 µM 3.64700999336817 4.58403341617021e-05 yes 12 0.00013265480478863 43 3092424 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 3.45470092260337 0.000105557165513379 yes 13 0.000275451780962366 37 688751 SGTC_272 doxorubicin 8.13 µM 3.41811507459732 0.000123145043073075 yes 14 0.000315282203111718 40 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1481 3346-2004 36 µM 3.39400881165265 0.000136197827395634 yes 15 0.000344387381585442 19 2770522 SGTC_996 3970-0799 1.8 µM 3.38926265186757 0.00013891596303257 yes 16 0.000350404244182384 124 6615648 YGL040C HEM2 SGTC_863 0466-0191 129 µM 3.36084224084833 0.000156285601056554 yes 17 0.00038852597536856 97 765160 YPR165W RHO1 SGTC_717 1532-0246 73.2 µM 3.29759026433199 0.000202500268148641 yes 18 0.000487591622376765 61 9561992 SGTC_83 0170-0301 39.027 µM 3.2335628869528 0.0002620532194085 yes 19 0.00061128208255536 11 3089716 SGTC_1058 3448-5425 97.3 µM 3.20683247485237 0.000291448133668493 yes 20 0.000671025622307568 55 7279705 SGTC_3166 9102297 49.47 µM 3.16549222369877 0.000343010055285767 yes 21 0.000774104000516518 59 25237072 SGTC_545 4218-0007 221 µM 3.09357810452765 0.00045337766067452 yes 22 0.000988792455398602 61 2840508 SGTC_1382 3002-2117 298 µM 3.08932908843949 0.00046083182961777 yes 23 0.00100304546323585 37 1497314 SGTC_2158 5657123 3.6195 µM 3.06507143326671 0.000505607537245539 yes 24 0.0010880900696626 23 2858827 SGTC_3187 9109394 49.47 µM 3.05740264442932 0.00052057992557338 yes 25 0.00111632076430315 73 17098090 SGTC_1976 st070609 63.5 µM 3.02468043690447 0.000589191511139211 yes 26 0.00124447978269494 41 682556 SGTC_1665 st014639 11.4 µM 3.00527138311019 0.000633742144997222 yes 27 0.00132671992261405 66 981133 YIL048W NEO1 SGTC_1388 3346-4487 254 µM 2.99800237122117 0.00065121285915001 yes 28 0.00135877779479375 67 3345614 SGTC_22 0964-0034 14.468 µM 2.90300099133864 0.000924288541718039 yes 29 0.00184802733567567 101 138402 SGTC_1861 st057647 17.4 µM 2.89825717357055 0.000940354030785654 yes 30 0.00187621378686089 63 688668 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.89444328045998 0.000953455791832594 yes 31 0.0018991576244642 64 4213774 SGTC_535 2293-4129 48.2 µM 2.85324415088009 0.00110606835513521 no 32 0.00216376795857301 137 396118 YIL048W NEO1 SGTC_2239 6685329 187.64 µM 2.84292738043135 0.00114763872313539 no 33 0.00223506271553716 95 805680 SGTC_2839 9003951 25.97 µM 2.83067253778372 0.00119887567105608 no 34 0.00232251252457117 57 2990634 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.82190441077436 0.00123681072902604 no 35 0.00238697021691498 82 2333 A French combination drug. SGTC_2717 st081029 62.2815 µM 2.80670393023465 0.00130518686853271 no 36 0.00250256102376098 48 5292846 SGTC_84 0443-0269 128.823 µM 2.78134119403664 0.00142700925702559 no 37 0.00270674044990818 82 6150058 SGTC_2302 7771753 200 µM 2.77436140703454 0.00146231001507355 no 38 0.00276550976439983 121 2203047 SGTC_2752 diclazuril 33.15 µM 2.7615432074071 0.00152922172786515 no 39 0.00287644519991434 226 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2770 toltrazuril 17.5 µM 2.75848881660805 0.00154557235582535 no 40 0.00290346460423889 94 68591 Kills coccidiodes. SGTC_307 1501-1223 22.3 µM 2.75470948390022 0.00156602430530173 no 41 0.00293721353369986 62 2830329 SGTC_1305 1181-0477 144 µM 2.69607894999645 0.00191654693903617 no 42 0.00350805176367573 82 6252086 SGTC_2856 9022925 19.48 µM 2.69146525131389 0.00194694984931386 no 43 0.00355694544061535 105 4944862 SGTC_2935 9038016 29.96 µM 2.66907550198985 0.00210080576038752 no 44 0.00380301751861118 101 6463195 SGTC_234 nsc-17383 10.7 µM 2.66226327493153 0.00214975939461403 no 45 0.00388085717331977 104 408974 SGTC_506 n9-isopropylolomoucine 153 µM 2.65339193517692 0.00221506020603048 no 46 0.0039843641139812 71 6610355 SGTC_3266 9136860 49.47 µM 2.6365559076781 0.00234395238642754 no 47 0.00418761988054285 120 4871271 YPR165W RHO1 SGTC_2372 9071633 200 µM 2.63639475447036 0.00234521828034651 no 48 0.00418960944530218 80 21321366 SGTC_2716 st080858 38.6235 µM 2.63410163542623 0.00236329842152573 no 49 0.00421801158382939 77 5296050 SGTC_3323 9138564 53.9225 µM 2.62854924585051 0.00240760007501364 no 50 0.00428749693509705 110 43912313 YNL103W MET4 SGTC_3217 9129673 49.47 µM 2.56797640679235 0.00294207128164987 no 51 0.00511470590462832 136 17248312 SGTC_2479 5617353 43.85 µM 2.56319322050546 0.00298852336968712 no 52 0.0051857155885397 123 2731746 SGTC_1494 4358-1428 177 µM 2.55116553662213 0.00310826448433171 no 53 0.00536816591091146 100 1564571 SGTC_1920 st075728 45.7 µM 2.512234636497 0.00352602606299419 no 54 0.00599846466930435 129 3400306 SGTC_1290 0986-0249 10.2 µM 2.49699083153367 0.00370288878959954 no 55 0.0062626097538205 83 53329 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.48644048861945 0.00382991438493997 no 56 0.00645140740266936 96 803109 SGTC_1983 st071813 46.9 µM 2.45721708300935 0.00420239825425105 no 57 0.00700090243740281 112 11838595 SGTC_2969 9091408 28.7 µM 2.4312310148107 0.00456048971118856 no 58 0.0075238084027474 152 4286311 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.40027069605422 0.00502250806434091 no 59 0.00819147578244431 159 442882 SGTC_2710 st078562 53.7235 µM 2.39565201379648 0.00509489376452695 no 60 0.00829541653781433 106 17250908 SGTC_525 k781-2675 26.7 µM 2.39491346897085 0.00510655424742274 no 61 0.00831214403104882 171 3651118 YDL195W SEC31 SGTC_934 2950-0684 338 µM 2.38626400283608 0.00524489483773131 no 62 0.00851026380990294 142 1121253 SGTC_3260 9137109 49.47 µM 2.38348883460235 0.00528998237199887 no 63 0.00857470234684591 70 17478346 SGTC_261 5-fluorouridine 15.376 µM 2.35890340829366 0.00570471362934742 no 64 0.00916451295188485 147 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3315 9136395 68.55 µM 2.35818344193163 0.00571728209492602 no 65 0.00918230768485208 128 16876844 SGTC_161 4065-0411 162.148 µM 2.35751410023421 0.00572898884583245 no 66 0.009198878297871 216 1906281 YLR208W SEC13 SGTC_1492 4158-0558 28.5 µM 2.34225102479009 0.00600177675097906 no 67 0.00958390902861159 139 3967268 SGTC_1326 1431-2094 10.8 µM 2.33271815990395 0.0061779370687313 no 68 0.00983147121986988 155 616278 SGTC_790 1575-0012 79.1 µM 2.32112289697804 0.00639837147824873 no 69 0.0101401059731809 160 378741 YLR208W SEC13 SGTC_1936 st074407 74.3 µM 2.32047437472496 0.00641090337869831 no 70 0.0101576147923662 200 809813 SGTC_1815 st051655 58.2 µM 2.31490257450495 0.00651946961606136 no 71 0.0103091322225469 86 5984156 SGTC_1923 st058458 19.1 µM 2.29228638725214 0.00697702161516367 no 72 0.0109445614105284 204 3534982 SGTC_3287 9117173 37.0625 µM 2.27760386430594 0.00728903056143095 no 73 0.0113750950307813 83 2789709 SGTC_1333 1482-0047 286 µM 2.26139140791654 0.00764778314709359 no 74 0.0118675151736908 173 3811116 SGTC_3283 9109332 35.8195 µM 2.2507923602715 0.00789064159614217 no 75 0.0121993458233758 119 17027281 SGTC_1776 st049249 45.9 µM 2.24330996824746 0.00806614731738691 no 76 0.0124384165067156 183 1822314 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.23305466399708 0.00831226417437431 no 77 0.012772669889043 137 756377 SGTC_330 1488-0319 80.1 µM 2.22602089532662 0.00848485723614503 no 78 0.0130063909184171 144 6846614 SGTC_297 0986-0032 24 µM 2.22455127797068 0.00852131301770158 no 79 0.0130556882563615 119 2847425 SGTC_568 1193-0097 7.48 µM 2.20653213600905 0.00897959997165206 no 80 0.0136733813552845 322 3646150 SGTC_737 1950-0117 57.9 µM 2.19477752599903 0.00929006785365372 no 81 0.0140897801872863 173 5393513 SGTC_23 0213-0011 39.996 µM 2.18823861014835 0.00946681033257105 no 82 0.0143261130139408 170 627608 SGTC_1473 k844-0725 134 µM 2.17343910894781 0.00987772543055092 no 83 0.0148736420175825 175 54682906 SGTC_85 0868-0259 160.055 µM 2.16238066257632 0.0101948540516851 no 84 0.0152944234242383 129 83173 SGTC_304 1310-0298 97 µM 2.15048258290861 0.0105459447154464 no 85 0.0157585311157624 251 1550234 SGTC_1807 st050092 58.9 µM 2.14830014099622 0.0106114755101845 no 86 0.0158449598544298 178 5008496 SGTC_2921 7974240 10.71 µM 2.14561188661179 0.0106926813186072 no 87 0.01595197815201 214 2979074 YDR527W RBA50 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.1329546750687 0.0110823395295312 no 88 0.016464222255936 246 551469 SGTC_785 1270-0111 65.3 µM 2.12947139804311 0.0111917175417811 no 89 0.0166076394118215 214 6741994 SGTC_1087 pterostilbene 9.05 µM 2.12115330797939 0.0114567169382771 no 90 0.0169544515534613 199 5281727 Similar to reservatol, lowers cholesterol. SGTC_1738 st035555 74 µM 2.11725572282192 0.0115827511285045 no 91 0.0171190752491969 220 5331140 SGTC_120 rhodamine 6G 52.259 µM 2.11166702096295 0.0117655701753473 no 92 0.0173575097995938 248 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1217 1183-1422 255 µM 2.10266900065908 0.0120651780600924 no 93 0.017747356827145 177 2849664 SGTC_367 0335-0881 7.1 µM 2.09731733741233 0.0122464919884198 no 94 0.0179827465557028 259 23828853 SGTC_2331 7980721 200 µM 2.07486608667955 0.0130331020257614 no 95 0.0189994737833351 220 2981221 SGTC_881 0833-0569 170 µM 2.07153555760654 0.0131534350797952 no 96 0.0191543875499719 226 5418700 SGTC_674 0498-0004 451 µM 2.07112557563034 0.0131683140170496 no 97 0.0191735311705295 220 4231473 SGTC_2581 avocatin a 64 µM 2.07056348343441 0.0131887369277771 no 98 0.0191998038307583 246 6710728 A skin care supplement. SGTC_1662 st014054 52 µM 2.06377034495115 0.0134377291881834 no 99 0.0195197480193605 138 2838777 SGTC_17 0960-0276 49.807 µM 2.05851340687098 0.0136331902293239 no 100 0.0197704378180457 246 6821114 SGTC_2576 guaiol 23.12 µM 2.05015053568609 0.0139491903136171 no 101 0.0201748715989403 223 227829 SGTC_1436 4092-1007 8.32 µM 2.04979436727153 0.013962787571178 no 102 0.0201922507565794 186 2881121 SGTC_784 4579-0127 173 µM 2.04473870884964 0.0141570304975134 no 103 0.0204403126043219 194 1948547 SGTC_2096 5468907 200 µM 2.03666733410501 0.0144719653805828 no 104 0.0208416950669506 175 759785 SGTC_1514 1189-1591 158 µM 2.03341284078553 0.0146006474436171 no 105 0.0210054155586166 257 767698 YMR146C TIF34 SGTC_1104 tacrolimus 29.8 µM 2.01618585327242 0.0152983205132362 no 106 0.0218902725788821 223 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1201 1889-3372 45.9 µM 2.01556413841028 0.0153240255971579 no 107 0.0219227864591505 169 5392199 SGTC_1339 1486-1321 22.7 µM 2.00069537116564 0.0159499258245887 no 108 0.0227126142846342 228 3469382 SGTC_1924 st058459 75.1 µM 1.99699394725246 0.0161091017135588 no 109 0.022912920256513 182 688683 SGTC_602 3130-1533 38.1 µM 1.99387899684021 0.0162441098526331 no 110 0.0230826398843241 244 720941 SGTC_395 anisomycin 6.25 µM 1.99290327359262 0.0162865984941458 no 111 0.0231360199014167 163 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2754 granisetron 64.02 µM 1.99128610208678 0.0163572291325079 no 112 0.0232247212493527 248 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1824 st053723 68.6 µM 1.98049745143506 0.0168351725795802 no 113 0.0238238297175105 232 675225 SGTC_2843 9000894 45.46 µM 1.96772497282899 0.0174163938110275 no 114 0.0245498454222645 123 2242070 SGTC_2336 9001819 198.65 µM 1.96746975044207 0.0174281803725611 no 115 0.0245645399778444 287 2989602 SGTC_2171 5739187 198.077 µM 1.96659672744196 0.0174685494259999 no 116 0.0246148605296329 183 2262761 SGTC_91 0417-1751 58.384 µM 1.96401750206888 0.0175882808624276 no 117 0.0247640311303766 306 6795624 SGTC_2750 bromebric acid 70.15 µM 1.95125042705834 0.0181913135141737 no 118 0.0255136314850794 268 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_702 1488-0190 94 µM 1.9481497551924 0.0183404000171572 no 119 0.0256985234099072 194 949357 SGTC_538 2922-0838 53.3 µM 1.93918018236432 0.0187775483510417 no 120 0.0262397009281385 297 777039 SGTC_2628 lathosterol 100 µM 1.93904085107824 0.0187844082483488 no 121 0.0262481820363071 242 6710616 SGTC_2283 7944793 200 µM 1.93578043306739 0.0189455429537753 no 122 0.0264472991930309 270 2970533 SGTC_1798 st045719 60.953 µM 1.90386775318921 0.0205857268136263 no 123 0.0284637048900836 177 3980186 SGTC_2179 6298986 200 µM 1.90004131694623 0.0207902374607816 no 124 0.0287138488773201 213 738374 SGTC_1991 st073000 8.92 µM 1.89687124638914 0.0209609679707349 no 125 0.0289224666116435 330 4301969 YIL048W NEO1 SGTC_56 0957-0365 83.25 µM 1.89239590016422 0.021204015716274 no 126 0.0292191259393971 284 6752360 SGTC_2011 4012611 177 µM 1.89237159249694 0.0212053423018917 no 127 0.0292207441082492 264 2049887 SGTC_3246 9135460 32.98 µM 1.88926702357662 0.0213753514954374 no 128 0.0294280289353602 167 41446951 SGTC_167 3672-0051 66.205 µM 1.8806843415494 0.0218513547800766 no 129 0.0300074354767984 260 3237971 SGTC_646 4092-0839 27.3 µM 1.87727658895799 0.0220428191436392 no 130 0.0302400975766465 251 877796 SGTC_3013 9080133 71.4286 µM 1.87590366166408 0.0221203561996579 no 131 0.0303342548839787 281 17050193 SGTC_1679 SEC14.276 6.7 µM 1.8753925362627 0.022149281115624 no 132 0.0303693705923608 315 1005053 YMR079W SEC14 SGTC_2055 5235184 200 µM 1.87186617693805 0.0223497110941137 no 133 0.0306125599889356 268 2836034 SGTC_2596 sinensetin 100 µM 1.86942456774096 0.0224893810047333 no 134 0.0307818845987932 262 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_164 4100-3994 89.624 µM 1.86742010156554 0.022604594057565 no 135 0.0309214724179391 323 4615967 SGTC_384 k007-0144 5.16 µM 1.86424304097627 0.0227882248676168 no 136 0.031143790795914 326 6824886 SGTC_1740 st038286 13.222 µM 1.86394510041412 0.0228055098109369 no 137 0.0311647071665099 275 716786 SGTC_744 1594-0068 283 µM 1.85394818865517 0.0233919146979715 no 138 0.0318732863952937 317 668392 SGTC_935 2996-0153 430 µM 1.84918070141189 0.0236760066633374 no 139 0.0322158622069547 247 23738523 SGTC_1502 4534-4282 27.7 µM 1.84431725067188 0.0239688010276529 no 140 0.0325684594482125 216 3278949 SGTC_3133 9127736 49.47 µM 1.83981158950775 0.0242427648263165 no 141 0.032897951670418 258 27243420 SGTC_2053 5265679 138 µM 1.83465760852544 0.0245593691755487 no 142 0.0332782185463688 303 764595 SGTC_2215 7188065 200 µM 1.82439148075626 0.0252003536007108 no 143 0.0340464545122399 188 940217 SGTC_1643 st009866 20.2 µM 1.82351713399205 0.0252555870204173 no 144 0.0341125522112539 228 3156273 YOR207C RET1 SGTC_2088 5278280 127.392 µM 1.81982167219741 0.0254901548822898 no 145 0.0343930831122268 311 791502 SGTC_622 1348-1566 26.3 µM 1.81977950786384 0.0254928417369736 no 146 0.0343962948079516 316 7340407 SGTC_853 0419-0306 21 µM 1.81322851277667 0.0259131840932628 no 147 0.0348982919406904 243 762713 SGTC_54 0159-0055 9 µM 1.81258171662048 0.0259549982834965 no 148 0.0349481799267825 268 3319099 SGTC_2413 inermin 26.06 µM 1.81214813562666 0.0259830600931247 no 149 0.0349816551911055 325 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1383 3049-0032 20.7 µM 1.80778207333681 0.0262670532982399 no 150 0.0353202124520375 285 712864 SGTC_430 0958-0115 16.4 µM 1.80682822858183 0.0263294408850812 no 151 0.0353945329300232 295 6833180 SGTC_3108 9121785 49.47 µM 1.80433463265031 0.0264931234907652 no 152 0.0355894318369172 273 17140271 SGTC_190 3970-0790 3.722 µM 1.79325488543036 0.0272307277704672 no 153 0.0364660887893382 251 2832352 SGTC_1309 pyrazolanthrone 13.4 µM 1.7890363003601 0.0275160357580219 no 154 0.0368044848193918 302 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3316 9136639 10.545 µM 1.78638612730648 0.0276965415188499 no 155 0.037018380118219 265 4903665 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.78388436800775 0.027867843089728 no 156 0.0372212282528269 312 5106787 A p450 inhibitor. SGTC_3334 9142812 21.919 µM 1.78331878425275 0.0279066920712554 no 157 0.0372672126706965 284 45283678 SGTC_383 2324-0395 7.37 µM 1.78183838251697 0.0280085919601851 no 158 0.0373877955408521 313 3146421 SGTC_3204 9114183 49.47 µM 1.77613824806981 0.0284038448581063 no 159 0.0378550666979335 297 17027248 SGTC_1025 k007-0731 70 µM 1.76663017637063 0.029073466454889 no 160 0.0386450919228 286 6256118 SGTC_1359 1582-0056 520 nM 1.76446953387827 0.0292274484825854 no 161 0.0388264801507 330 3661189 SGTC_1444 4112-3581 28 µM 1.74194881268507 0.0308731199684108 no 162 0.0407587007542941 285 2877249 SGTC_3284 9108171 64.8615 µM 1.73000787063158 0.0317763497186294 no 163 0.0418144345142146 268 8687505 SGTC_2708 st078559 56 µM 1.7260760231499 0.0320784959318387 no 164 0.0421668683668548 211 17250902 SGTC_1271 0832-2808 169 µM 1.72111921393997 0.0324627823995863 no 165 0.0426145966857014 318 3663794 SGTC_275 trichlorophene 5.69 µM 1.71305330268294 0.033096221204122 no 166 0.0433513669398551 541 62616 SGTC_3012 9080433 71.4286 µM 1.71058839614049 0.0332918166434639 no 167 0.0435785612895363 305 17688859 SGTC_179 1273-0063 6.77 µM 1.70774885685728 0.0335183189900756 no 168 0.0438414762167361 275 3108139 SGTC_1455 4262-0120 131 µM 1.70631106863702 0.0336334903485136 no 169 0.0439750891735332 328 1529587 SGTC_1795 st049545 62.3 µM 1.6985484584376 0.0342609387667623 no 170 0.0447021474288922 295 5291882 SGTC_3297 9117502 71.43 µM 1.69400387652639 0.034632719223122 no 171 0.0451322732090095 262 7453720 SGTC_2791 5663188 71.43 µM 1.69167599486471 0.0348244367677632 no 172 0.0453538839312052 320 54690634 SGTC_2308 7584454 197.62 µM 1.69094107257909 0.0348851434794043 no 173 0.0454240288934779 380 893577 SGTC_3343 9148379 18.9835 µM 1.6879418025691 0.0351337932235639 no 174 0.0457112005617775 315 1955036 SGTC_910 3454-3003 490 µM 1.68549915339478 0.0353373699503069 no 175 0.0459461540087541 376 820824 SGTC_2411 st077133 39.94 µM 1.68305697872198 0.0355418732940508 no 176 0.0461820308481997 395 1403142 YNL221C POP1 SGTC_1350 1495-0454 146 µM 1.67838809959608 0.0359355372963488 no 177 0.0466356796359478 391 1069057 SGTC_1081 sertraline 6 µM 1.67671090684253 0.0360778215898362 no 178 0.0467995133879351 386 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_344 k064-0035 6.43 µM 1.67412022630361 0.036298507861609 no 179 0.0470534866993397 330 5088750 SGTC_1553 gossypol 38.6 µM 1.67234019323538 0.0364507789176698 no 180 0.0472286290818959 200 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_226 1,3-diallylurea 8.28947 mM 1.66920301830975 0.0367204175044305 no 181 0.0475385760743651 286 74537 YKL182W FAS1 SGTC_1191 1487-1166 10.6 µM 1.66334958512764 0.0372278780391028 no 182 0.048121239253985 417 3955771 SGTC_1454 4239-0054 42.6 µM 1.6624449059671 0.0373068176037654 no 183 0.0482118006712616 391 1340767 SGTC_379 3970-0972 5.9 µM 1.66217734526794 0.0373301903246073 no 184 0.0482386105059501 342 2898042 YBL034C STU1 SGTC_271 rotenone 740 µM 1.66002499044269 0.03751864438413 no 185 0.0484547126209859 369 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_997 3996-0078 137 µM 1.6580539538376 0.0376919035264262 no 186 0.0486532883719392 361 735687 SGTC_1878 temozolomide 1 mM 1.65761123605662 0.0377309092386178 no 187 0.0486979801490935 291 5394 DNA alkylating agent. SGTC_3168 9103419 49.47 µM 1.65587075274951 0.0378845742673825 no 188 0.0488739978286655 211 16649256 SGTC_2797 7859098 81.82 µM 1.65571097949645 0.0378987059966474 no 189 0.0488901813806068 361 972681 SGTC_3327 9140648 26.9345 µM 1.65468209230748 0.0379898127536426 no 190 0.0489945007293636 317 8029710 SGTC_973 1325-0077 65.9 µM 1.65416633874068 0.0380355493171359 no 191 0.0490468600942524 365 2835149 SGTC_2927 9011802 47.9 µM 1.65387833327081 0.0380611089224896 no 192 0.0490761178883001 349 43912568 SGTC_665 3914-0008 307 µM 1.64889572988734 0.0385055218954612 no 193 0.0495844990530267 352 1069549 SGTC_801 0866-0028 10.1 µM 1.64871313032952 0.0385218884795717 no 194 0.0496032094431547 384 6849771 SGTC_73 0327-0325 16.231 µM 1.64810411941274 0.0385765157389978 no 195 0.0496656535701821 420 53298 SGTC_2552 juarezic acid 87.02 µM 1.64735621014309 0.038643688295103 no 196 0.0497424252509514 408 1549512 SGTC_2831 7999036 19.48 µM 1.64636695404308 0.038732683484623 no 197 0.0498441161944415 386 2988270 SGTC_593 1203-0218 61.7 µM 1.64615748331694 0.0387515492370513 no 198 0.0498656700738903 337 3666956 SGTC_855 0428-0020 25 µM 1.64276181720914 0.0390584217539891 no 199 0.0502161115564135 301 6812414 SGTC_2515 chrysin 20.77 µM 1.63561365461329 0.0397108809700562 no 200 0.0509602353904389 314 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3305 9127027 53.8275 µM 1.63551796960819 0.0397196745029561 no 201 0.0509702554125683 343 41905295 SGTC_873 0591-4978 488 µM 1.62942752766471 0.0402826569965272 no 202 0.0516112726380361 372 3305145 SGTC_1893 st059353 36.1 µM 1.62692381521025 0.0405159647277267 no 203 0.0518766396399139 370 3112488 SGTC_2584 androsterone 48.74 µM 1.61533365754207 0.0416103219211003 no 204 0.0531192293160225 529 2754130 A steroid. SGTC_818 4072-2707 53.5 µM 1.61403716877156 0.0417342132656623 no 205 0.0532596821921349 318 882871 SGTC_2423 st077119 87.2 µM 1.61312141175872 0.0418219021209511 no 206 0.0533590664291257 352 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1223 0764-0573 147 µM 1.61239574142332 0.0418914950205406 no 207 0.0534379254897915 401 1609797 SGTC_2747 doxorubicin 7.63 µM 1.60722117543811 0.0423904660657904 no 208 0.0540029292311358 213 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_745 0469-0705 296 µM 1.6066567123306 0.0424451855004352 no 209 0.0540648471816797 416 3486736 SGTC_692 k241-0027 77.8 µM 1.60645989401268 0.0424642786285807 no 210 0.0540864500854134 344 3600480 SGTC_1574 spiramycin 23.7 µM 1.6057325422247 0.0425348985003793 no 211 0.0541663439627787 398 6419898 An antibiotic and protein synthesis inhibitor. SGTC_690 glyoxal 20.3 µM 1.60010478044267 0.043084523504285 no 212 0.0547876703396 428 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_529 4076-0302 30.3 µM 1.591977539773 0.0438883659068827 no 213 0.0556948756411918 386 5816522 SGTC_1220 1838-0075 193 µM 1.58800058650181 0.0442860999739916 no 214 0.0561431032499785 379 5529645 SGTC_1854 st056233 32.9 µM 1.5828601643484 0.0448044909464629 no 215 0.0567266700236768 345 5393174 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.57644859049998 0.045457907947649 no 216 0.0574612288641087 394 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_953 1188-0045 9.7 µM 1.57388546721503 0.0457212560411453 no 217 0.0577569651451755 407 6144426 SGTC_2659 sanguinarine 24.21 µM 1.57375883088084 0.0457342990152092 no 218 0.0577716075660899 371 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3160 9100216 49.47 µM 1.57316033170985 0.0457959822164468 no 219 0.0578408489766184 365 17191039 SGTC_756 0508-1999 28.3 µM 1.55212999309961 0.0480062147488422 no 220 0.0603155613481198 383 6753853 SGTC_3340 9146634 11.102 µM 1.55189156265435 0.048031754134811 no 221 0.0603440860480598 380 4907387 SGTC_1202 1988-0068 29.6 µM 1.54875240657954 0.0483690186994438 no 222 0.0607206252605529 403 2850480 SGTC_175 3793-3120 23.7 µM 1.54855741137623 0.048390030915037 no 223 0.0607440752586865 366 5322297 SGTC_1248 0469-0687 58.6 µM 1.54713955734178 0.0485430350847692 no 224 0.060914798518628 407 4017482 SGTC_294 k038-0071 157 µM 1.546663330956 0.0485945125592073 no 225 0.0609722248413689 430 24152826 SGTC_282 k297-0036 65.7 µM 1.54555877631936 0.048714076900742 no 226 0.0611055817865115 332 5061378 SGTC_943 3253-1379 105 µM 1.54107334276958 0.0492020282327573 no 227 0.0616494684205274 392 668464 SGTC_1972 st070201 17.4 µM 1.53827489881091 0.0495084311592508 no 228 0.0619907072212459 376 2829099 SGTC_3034 9090421 49.47 µM 1.53810837651054 0.0495267116638637 no 229 0.0620110591146162 349 17173761 SGTC_1889 st059080 5.18 µM 1.53765558863305 0.0495764451045662 no 230 0.062066423954687 427 176925 Isolated from Daphnopsis sellowiana. SGTC_893 0958-0369 48.9 µM 1.53755768461249 0.0495872039523529 no 231 0.0620784002822649 432 6819948 SGTC_1840 st055363 71 µM 1.53556244919247 0.0498068701240163 no 232 0.0623228649035765 352 676033 SGTC_2018 5133068 143 µM 1.53517666632377 0.0498494324505293 no 233 0.0623702191421129 403 785362 SGTC_1246 0422-0085 105 µM 1.533694048445 0.0500132755208406 no 234 0.0625524693112744 446 264295 SGTC_1941 st076221 61.8 µM 1.5318505225852 0.0502176008920219 no 235 0.0627796626718013 477 2828568 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.52930138310932 0.0505012277731363 no 236 0.0630948734579371 456 4174840 SGTC_2407 paclitaxel 400 µM 1.52849364708457 0.0505913653215702 no 237 0.0631950098322859 445 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3271 9137798 49.47 µM 1.52743586801413 0.0507095996267871 no 238 0.0633263315471699 321 6498326 SGTC_1668 st014914 51.6 µM 1.52685517730985 0.0507746004066773 no 239 0.0633985137145569 362 2839556 SGTC_3313 9133968 57.047 µM 1.52585784650384 0.0508863934438801 no 240 0.0635226353402843 417 1494643 SGTC_1698 5-fluorocytosine 1.055 µM 1.52505912528188 0.0509760651243158 no 241 0.0636221755501886 367 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_347 4534-1311 26.2 µM 1.52389583173796 0.0511068919489132 no 242 0.0637673674440198 403 2862016 SGTC_1479 0549-0158 134 µM 1.51998106357694 0.0515491198321349 no 243 0.0642578674919085 441 5440202 SGTC_1390 3413-2614 145 µM 1.5170403466127 0.05188331205784 no 244 0.0646282488797059 426 3421432 SGTC_1135 dihydrocapsaicin 536.708 nM 1.51587220224304 0.0520165404705855 no 245 0.0647758352380091 428 107982 A Capsaicinoid. SGTC_2357 9067248 200 µM 1.51524452487496 0.0520882400843542 no 246 0.064855245626791 386 9150235 SGTC_2902 5787006 60.46 µM 1.51489409800155 0.0521283034990376 no 247 0.0648996126296295 415 591003 SGTC_74 000s-0487 160.283 µM 1.51473511985219 0.0521464871363062 no 248 0.0649197483744675 422 677548 SGTC_2201 6605497 169.863 µM 1.51353374781359 0.052284060865532 no 249 0.0650720677621056 374 670741 SGTC_1362 1611-0397 101 µM 1.51079751642072 0.0525984730051941 no 250 0.0654200238429277 409 27816 SGTC_2290 7904846 200 µM 1.50990022245243 0.0527019044630052 no 251 0.0655344429618338 434 2962154 SGTC_2032 5185112 25.99 µM 1.50893414135091 0.0528134453937731 no 252 0.0656578069438225 385 5718189 SGTC_2235 salicylic acid 500 µM 1.50803232691716 0.0529177352097312 no 253 0.0657731267794645 360 338 A COX inhibitor and kinase inhibitor. SGTC_1142 3253-1408 9.78 µM 1.50301079275272 0.0535014379032485 no 254 0.0664181304389689 398 256655 SGTC_2249 haloperidol 116.36 µM 1.50243964793804 0.0535681495903471 no 255 0.0664918016967239 561 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1186 1319-0216 26 µM 1.49917062868712 0.0539512512592445 no 256 0.0669146862797741 453 4565136 SGTC_3354 9151612 71.43 µM 1.49908132901504 0.0539617467887016 no 257 0.0669262673273554 441 27261949 SGTC_382 3229-0966 23.2 µM 1.49740933166202 0.0541585578550736 no 258 0.0671433908211212 437 5722370 SGTC_2707 st078556 66.6 µM 1.49253758018563 0.0547352526412448 no 259 0.0677791365389042 392 17250899 SGTC_1684 st024538 14.6195 µM 1.49096988349201 0.0549218580892795 no 260 0.0679847010158301 416 6732859 SGTC_2065 5221596 34.26 µM 1.48861073081239 0.0552036189688332 no 261 0.0682949521157789 417 788581 SGTC_417 st075190 100 µM 1.47746761526773 0.0565499389474506 no 262 0.0697751665199867 445 222757 SGTC_795 0685-0265 78 µM 1.47645533137893 0.0566735148351393 no 263 0.0699108491089756 466 302754 SGTC_3111 9122088 49.47 µM 1.47416772338121 0.0569535611675797 no 264 0.0702182189388318 313 16876704 SGTC_2046 4110841 106 µM 1.46720204295513 0.0578130055728692 no 265 0.071160550679301 425 44119630 YMR134W ERG29 SGTC_2787 5284540 71.43 µM 1.46640865473302 0.0579115393444712 no 266 0.0712684949621477 441 736958 SGTC_1911 st060208 74.3 µM 1.46069507850451 0.0586250324722106 no 267 0.0720495701397214 482 688783 SGTC_1719 st032227 49.2 µM 1.45789842547018 0.0589767760782712 no 268 0.0724342713539323 445 3125804 SGTC_1787 fluconazole 80 µM 1.45711385396692 0.0590757508563303 no 269 0.0725424773882615 523 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_890 0929-0006 47.2 µM 1.45689246850555 0.0591037024939735 no 270 0.0725730326747508 414 1378169 SGTC_2647 atorvastatin 60.16 µM 1.45495186436305 0.0593491630809352 no 271 0.0728412939953719 421 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2002 4023503 131 µM 1.45423307651954 0.0594402827511518 no 272 0.0729408487813858 561 4736863 YCR052W RSC6 SGTC_2953 9074162 66.49 µM 1.44958557882578 0.0600320885253025 no 273 0.0735870599517449 396 16451992 SGTC_2166 5933061 31.504 µM 1.44853202800905 0.0601668855941291 no 274 0.0737341576938294 449 2877375 SGTC_3292 9120825 59.784 µM 1.4451601154673 0.0605998998131614 no 275 0.0742064582664404 432 24824900 SGTC_3004 9076122 71.4286 µM 1.44181080108924 0.0610324216179238 no 276 0.0746778774948998 458 44782551 SGTC_2691 st077356 60.2 µM 1.43757095421066 0.0615834008452919 no 277 0.075277913578477 465 2839272 SGTC_287 k060-0039 29.6 µM 1.43296471374707 0.0621863879689697 no 278 0.0759339608272248 435 5861974 SGTC_680 0417-1641 114 µM 1.43123421316217 0.0624141083671222 no 279 0.0761815505821389 425 2835990 SGTC_2910 7948405 25.97 µM 1.42541585834777 0.0631845292548586 no 280 0.0770185133217182 409 2971328 SGTC_355 1311-2252 105 µM 1.41941564361848 0.0639867659541951 no 281 0.0778889371511259 484 5338538 SGTC_912 3474-0017 2.18 µM 1.41176514258743 0.0650211090965144 no 282 0.0790095626095641 485 3360550 SGTC_2742 clothiapine 36.27 µM 1.41140304747517 0.0650703839138885 no 283 0.079062902451846 400 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1548 st061468 90.8 µM 1.40519272747134 0.0659200182318096 no 284 0.0799819880686624 469 390799 SGTC_2909 7941780 10.49 µM 1.40039773797358 0.0665818827246699 no 285 0.0806971235138394 480 1243215 SGTC_1868 st057644 42.7 µM 1.3992599783028 0.0667396830882389 no 286 0.0808675182136117 506 688665 SGTC_2187 6125751 200 µM 1.39914901358342 0.066755088697358 no 287 0.0808841511884973 497 874498 SGTC_154 3389-1638 511.116 µM 1.39831212030782 0.0668713660861815 no 288 0.0810096798924757 417 5238686 SGTC_292 k038-0015 474 µM 1.39721772593277 0.0670236568545887 no 289 0.0811740539273338 451 46368540 SGTC_2286 7945697 125 µM 1.39564311414464 0.0672432428640464 no 290 0.0814109962253224 483 1245733 SGTC_118 0083-0097 135.343 µM 1.39457189200992 0.0673929467644219 no 291 0.081572488046273 731 5207356 SGTC_1120 ficusin 1.78878 µM 1.38976949816832 0.0680672520515319 no 292 0.0822994415620842 491 6199 A DNA cross-linker. SGTC_1478 0453-0656 35.7 µM 1.38814407217374 0.06829665453043 no 293 0.0825465893043082 487 5258496 SGTC_3252 9135871 49.47 µM 1.38492099728576 0.0687533031601441 no 294 0.0830383128935748 478 17682838 SGTC_2917 7979103 53.79 µM 1.38257216694751 0.0690875682939072 no 295 0.0833980441094934 557 2980565 SGTC_1683 st010134 710 nM 1.3811942100615 0.0692842492069365 no 296 0.0836096272729717 490 3818134 SGTC_3264 9137442 49.47 µM 1.38035619749258 0.0694040726156616 no 297 0.0837384998976192 443 17015726 SGTC_1239 0337-0584 35.4 µM 1.37324099452588 0.070427881096042 no 298 0.0848387196411191 563 914301 YML130C ERO1 SGTC_443 clozapine 122 µM 1.37108879188098 0.070739838400531 no 299 0.0851736392309992 402 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2347 9049783 174.81 µM 1.37021323641396 0.0708670517647666 no 300 0.0853101738085535 538 6467988 YPL169C MEX67 SGTC_2324 6149169 200 µM 1.3681908345023 0.0711615673310302 no 301 0.085626174897025 459 2888231 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.36612491542004 0.071463389592715 no 302 0.0859498796280723 415 77254 SGTC_2777 climbazole 1.536 µM 1.36587973571475 0.0714992744536341 no 303 0.0859883570538114 536 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2519 cryptotanshinone 88.04 µM 1.36577295553356 0.0715149072792358 no 304 0.0860051186948439 470 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1102 cgs 12066b 26.1 µM 1.36563118126898 0.0715356673593728 no 305 0.0860273772515191 463 6438352 A 5-HT1B full agonist. SGTC_1806 st050005 60.3 µM 1.36545740907415 0.0715611192204863 no 306 0.0860546653614369 504 5194765 SGTC_683 panaxydol 45 µM 1.36169432826272 0.072113991716023 no 307 0.0866471859758456 529 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3234 9132280 49.47 µM 1.36071570630785 0.0722583061218999 no 308 0.086801774571225 524 17612295 SGTC_2932 9016711 44.54 µM 1.35762075695927 0.0727161658794051 no 309 0.0872920265412417 559 7117328 SGTC_440 fluspirilene 35.1 µM 1.35743124589732 0.0727442737312278 no 310 0.0873221128570181 522 3396 An atypical antipsychotic. SGTC_333 3486-0131 40.1 µM 1.35616758907274 0.0729319091795705 no 311 0.0875229258780309 505 6744690 SGTC_3299 9121982 43.1275 µM 1.34997902355929 0.0738561788349534 no 312 0.0885113557563948 521 17594604 YPL160W CDC60 SGTC_2748 diazoxide 86.69 µM 1.34696925571994 0.0743089143072342 no 313 0.0889950673015832 441 3019 A potassium channel activatior. SGTC_1726 st035556 14.5795 µM 1.3460845564297 0.0744423948049126 no 314 0.0891376243046373 551 5919439 SGTC_251 melphalan 456.522 µM 1.34010396262343 0.0753495327531503 no 315 0.0901057739915789 584 460612 A DNA alkylator. SGTC_1125 tnp00248 1.32998 µM 1.33932000797876 0.0754690651662162 no 316 0.0902332589714685 644 24207736 SGTC_727 3032-0951 202 µM 1.33873273911653 0.0755587028155107 no 317 0.0903288470782497 475 3652836 SGTC_2205 7238770 200 µM 1.33577396743192 0.0760115486284786 no 318 0.0908115821409258 473 279867 SGTC_1442 4112-3290 3 µM 1.33411510002875 0.0762663439768273 no 319 0.0910830689257856 540 704353 SGTC_1784 st039334 36.3 µM 1.32819535271875 0.0771808933074984 no 320 0.0920567896370848 526 3496984 SGTC_1222 0366-0074 1.18 µM 1.32692036150967 0.0773789545164439 no 321 0.0922675140435344 546 286520 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.32422410204783 0.077799071180767 no 322 0.0927143142513279 550 3256 An antibiotic and ribosome inhibitor. SGTC_1080 nisoldipine 24.4 µM 1.3233207513073 0.0779402129380899 no 323 0.0928643668167025 569 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2307 7538926 6.34 µM 1.32155922896343 0.0782159962742444 no 324 0.0931574837098354 557 96582 SGTC_2785 7756463 72.73 µM 1.32038795168608 0.078399780302994 no 325 0.0933527620680261 516 2201551 SGTC_3308 9128332 17.569 µM 1.31950809037503 0.0785380537449068 no 326 0.0934996535939652 627 17332805 YDL196W YDL196W SGTC_446 go6976 132 µM 1.3187611872552 0.0786555773197817 no 327 0.0936244818537307 488 3501 A protein kinase C inhibitor. SGTC_2127 5253358 187.912 µM 1.31809659688187 0.0787602611769762 no 328 0.0937356567918252 477 20612 SGTC_411 enrofloxacin 100 µM 1.31407648856119 0.079395745919172 no 329 0.0944102326887093 510 71188 A bacterial gyrase inhibitor. SGTC_2960 9079389 5.97 µM 1.31280962372765 0.0795968095866755 no 330 0.094623553177432 549 16457355 SGTC_911 3456-4043 236 µM 1.31127001593273 0.0798416785065687 no 331 0.0948832773720344 564 914281 SGTC_2998 9066762 71.4286 µM 1.31082545744893 0.0799124897838288 no 332 0.09495836982099 598 4945196 SGTC_859 0439-0102 54.6 µM 1.30843473418711 0.0802941096004903 no 333 0.0953629489593744 593 610143 SGTC_3183 9108214 49.47 µM 1.2996651293293 0.0817057562975423 no 334 0.0968578833927519 388 4974831 SGTC_2507 purpurin 79.67 µM 1.29943837873961 0.0817425029819536 no 335 0.0968967639680863 562 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_310 1273-0058 1.06 µM 1.29592920526234 0.0823127809859237 no 336 0.0974999381524088 776 2734232 SGTC_567 1080-0542 68.4 µM 1.29480694682008 0.0824957907702942 no 337 0.0976934174807359 489 5950415 SGTC_111 0083-0039 52.457 µM 1.29303438600394 0.082785470907771 no 338 0.0979995832786098 385 759313 SGTC_2354 9060492 162 µM 1.29296064451472 0.082797538646971 no 339 0.0980123355036298 620 6471895 SGTC_2801 7907800 81.82 µM 1.29139625766239 0.083053861366562 no 340 0.0982831538260029 579 6620925 SGTC_2963 9082507 9 µM 1.28968685987654 0.0833346257800761 no 341 0.0985797018591526 516 16459611 SGTC_978 1416-0512 87.4 µM 1.28934507601076 0.0833908484364245 no 342 0.0986390733595596 601 6814003 SGTC_2050 5263056 171 µM 1.28632499079186 0.0838888850804032 no 343 0.099164832136501 642 763468 YGL055W OLE1 SGTC_2533 agelasine 13.65 µM 1.28059450724375 0.0848400237612184 no 344 0.100168065156245 595 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2444 5485484 36.41 µM 1.28045762669661 0.0848628414945684 no 345 0.100192119042881 577 6790631 SGTC_2602 kawain 100 µM 1.28045473897699 0.0848633229216239 no 346 0.100192626544478 618 5369129 SGTC_1372 2752-0194 270 µM 1.27762701165913 0.0853357316977199 no 347 0.100690485840213 519 823334 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.27594108894411 0.0856183229563374 no 348 0.100988172389273 510 279621 SGTC_768 0384-0033 77.3 µM 1.27465940205922 0.0858336253381776 no 349 0.101214911149708 626 3965305 YMR134W ERG29 SGTC_1680 diphenhydramine 100 µM 1.27050221494253 0.0865347534845321 no 350 0.101952897188249 555 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2150 5556613 200 µM 1.26921939802685 0.0867519683501516 no 351 0.102181412205488 603 743190 SGTC_1647 st011722 22.4 µM 1.26870269726037 0.0868395744847725 no 352 0.102273560052702 529 2854783 SGTC_2669 eugenol 100 µM 1.26863280532007 0.0868514296717667 no 353 0.102286029143858 497 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2623 humulene 100 µM 1.26467669461042 0.0875244447348582 no 354 0.102993623800406 493 6187145 An anti-inflammatory. SGTC_668 1682-0499 62.6 µM 1.26445191433818 0.087562800965991 no 355 0.10303393476012 629 682214 SGTC_1419 3993-2473 62.6 µM 1.26206024105585 0.0879716902091221 no 356 0.10346355522021 593 704026 SGTC_121 0557-0495 61.343 µM 1.26038757377014 0.0882585005069177 no 357 0.103764791057842 740 3104427 SGTC_413 propylparaben 100 µM 1.25989418095395 0.0883432349583544 no 358 0.103853769098183 561 7175 A pharmaceutical preservative. SGTC_99 0109-0120 622.8 µM 1.25897564213359 0.0885011447321986 no 359 0.104019564997205 521 759414 SGTC_762 1165-0429 115 µM 1.25596184729894 0.089020735438852 no 360 0.104564901571129 584 5967793 SGTC_1892 st058411 7.36 µM 1.25350484168246 0.0894460107938436 no 361 0.105011019078521 653 3934738 SGTC_1882 5615643 20 µM 1.25112043184222 0.0898601637923625 no 362 0.105445271098856 533 2253075 SGTC_2466 5983409 37.09 µM 1.25053188171502 0.0899626092376149 no 363 0.105552658249925 568 2879657 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.24460668448365 0.0909988125851875 no 364 0.10663818103135 686 368090 SGTC_2066 5222451 176 µM 1.2441925050105 0.0910715743278361 no 365 0.106714360781776 642 2281147 SGTC_2643 anethole 100 µM 1.24415086306791 0.0910788922395267 no 366 0.106722022128431 610 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1590 st077108 57.8 µM 1.24240564829767 0.0913859783699949 no 367 0.107043466348652 565 5489485 SGTC_10 0279-0212 42.575 µM 1.24216457674739 0.0914284573234965 no 368 0.107087923200451 697 39851 YBR002C RER2 SGTC_760 0568-0725 82.9 µM 1.23821055133808 0.0921272818804005 no 369 0.107819000098745 617 3916171 SGTC_386 1509-0011 3.07 µM 1.237522221372 0.0922493386414478 no 370 0.107946634917367 685 3107280 SGTC_2393 9031399 185.94 µM 1.23583347812272 0.092549298704756 no 371 0.108260234001968 579 1526623 YDL150W RPC53 SGTC_2434 5670830 169.91 µM 1.235028059718 0.0926926136097206 no 372 0.108410030664064 593 1549830 SGTC_637 1181-0519 7.26 µM 1.23474051227209 0.0927438190975296 no 373 0.108463546614291 695 6252091 YGR060W ERG25 SGTC_3116 9124943 49.47 µM 1.23271977056636 0.0931042562106209 no 374 0.108840166504017 542 41905195 YPL160W CDC60 SGTC_726 3448-4391 34.2 µM 1.23038561502015 0.0935218839209893 no 375 0.109276368757874 642 1356692 SGTC_778 3456-2434 196 µM 1.22916931946687 0.0937400513622933 no 376 0.109504164708668 681 5539063 SGTC_138 0850-0259 40.9225 µM 1.22743683399957 0.0940514564233169 no 377 0.109829224665867 725 6813004 SGTC_2220 6782180 200 µM 1.22170394138844 0.0950873549277118 no 378 0.110909802636252 514 833803 SGTC_3261 9137475 49.47 µM 1.22169566116265 0.0950888571667786 no 379 0.110911368842829 380 17027690 SGTC_891 0929-0073 133 µM 1.2186319323877 0.0956458943111249 no 380 0.111491961740921 618 5603632 SGTC_2136 5328288 199.296 µM 1.21696000402615 0.0959508896953208 no 381 0.111809716840741 519 262395 SGTC_512 prima-1 270 µM 1.21692300271309 0.095957647604091 no 382 0.11181675637179 632 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2740 felodipine 17.08 µM 1.21594617914395 0.0961361809852092 no 383 0.112002712537982 527 3333 L-type calcium channel blocker SGTC_2079 5212404 121 µM 1.21494144279563 0.0963200706124317 no 384 0.112194212977577 591 758462 SGTC_1967 st070177 51.4 µM 1.21373514053844 0.0965411927370876 no 385 0.112424440425895 582 5729214 SGTC_1708 st033234 31.827 µM 1.21274431314506 0.0967230958637474 no 386 0.112613795985166 645 674664 SGTC_544 k015-0020 52.4 µM 1.21189698220406 0.0968788544637494 no 387 0.112775908745439 588 3008304 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.21178268784167 0.0968998784418667 no 388 0.112797788479452 655 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_938 3126-1755 342 µM 1.21007351008265 0.0972146743587625 no 389 0.113125343415382 645 1777771 SGTC_2890 9046729 58.44 µM 1.20810111824076 0.0975788808975566 no 390 0.11350418483258 541 903329 SGTC_2443 5493264 126.67 µM 1.20808773645376 0.097581355286978 no 391 0.1135067581863 616 5340055 SGTC_247 mechlorethamine 29.705 µM 1.20793830159194 0.097608990002117 no 392 0.113535497739411 556 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2972 9093619 59.92 µM 1.20784084774808 0.0976270150542253 no 393 0.113554243014479 590 25236256 SGTC_3082 9117008 49.47 µM 1.20769857814906 0.0976533336057314 no 394 0.1135816125751 611 41448529 SGTC_3213 9129884 49.47 µM 1.20608230547717 0.0979526943464243 no 395 0.113892878373585 530 17190742 SGTC_3128 9127691 49.47 µM 1.20536303037458 0.0980861321604853 no 396 0.114031593420046 510 41316314 SGTC_39 0986-0283 58.349 µM 1.20521026311264 0.0981144902358754 no 397 0.114061070679977 687 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_798 1287-0182 476 µM 1.20516697069147 0.0981225276686479 no 398 0.114069425171111 678 1649755 SGTC_2226 7298446 200 µM 1.20499862622442 0.0981537861612344 no 399 0.114101916117278 565 3283010 SGTC_2624 nerol 100 µM 1.20483594850064 0.0981839993733953 no 400 0.114133319628894 594 637566 A natural product oil. SGTC_1525 8-methoxypsoralen 92.5 µM 1.20454345703172 0.0982383392928413 no 401 0.114189798032531 689 4114 Related to psoralen; DNA damaging agent. SGTC_1370 2001-0092 44.6 µM 1.20195101327314 0.0987209342441892 no 402 0.114691254041035 718 790957 SGTC_1483 3453-0561 55.9 µM 1.20171659727903 0.0987646572145003 no 403 0.114736674221489 662 4546991 SGTC_534 k292-0788 63.4 µM 1.19872832321495 0.0993232685166615 no 404 0.115316800567224 691 4146317 SGTC_1171 0368-0077 21.4 µM 1.19656850501105 0.0997284485929519 no 405 0.115737391212475 584 3239779 SGTC_1014 4130-3005 69.3 µM 1.19647262630978 0.099746463308682 no 406 0.115756087305989 645 743608 SGTC_2686 alizarin 95.37 µM 1.19519233163894 0.0999872466248574 no 407 0.116005946960755 585 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_817 1391-0715 46 µM 1.19506330443484 0.100011536122803 no 408 0.116031148863137 597 1353946 SGTC_961 1252-1571 372 µM 1.19372718666141 0.100263314970453 no 409 0.11629235111046 637 6813498 SGTC_2811 7967822 32.47 µM 1.18968657409715 0.101027545029263 no 410 0.117084802124994 628 2232244 SGTC_1524 corynanthine 62.1 µM 1.18775167484139 0.101395006242139 no 411 0.117465629235026 601 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2848 9016370 25.97 µM 1.18506606382421 0.101906649002725 no 412 0.117995663754036 701 7894410 SGTC_2810 7959871 45.46 µM 1.18496749758806 0.101925462795537 no 413 0.118015149005653 677 2974535 SGTC_375 3970-0961 9.27 µM 1.18139616271667 0.10260884600975 no 414 0.118722690853144 636 2898222 SGTC_1159 4092-0538 61.2 µM 1.17960535522012 0.102952772290427 no 415 0.119078606021362 676 717301 SGTC_597 k018-0003 82.8 µM 1.17943321948023 0.102985875188158 no 416 0.119112856890601 702 6786234 SGTC_763 3453-1109 128 µM 1.17450045856718 0.103937767130026 no 417 0.120097314186309 674 1560353 SGTC_2557 derrustone 83.84 µM 1.17308337245482 0.104212403282782 no 418 0.120381186851804 661 629853 An antioxidant. SGTC_227 fluconazole 33.516 µM 1.16911050568121 0.104985162216352 no 419 0.12117955586495 678 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2252 omeprazole 400 µM 1.16403335674593 0.105978740541408 no 420 0.122205247027106 542 4594 A proton pump inhibitor. SGTC_601 0986-0029 62.9 µM 1.16358621803648 0.10606656832103 no 421 0.122295869635036 676 24747981 SGTC_2130 NSC 7 2.4545 µM 1.16350377232317 0.106082768195019 no 422 0.122312584242662 688 21448 SGTC_671 0560-0003 407 µM 1.16317676700914 0.106147039534541 no 423 0.12237889536219 619 3238678 SGTC_1421 4029-0249 71.4 µM 1.16195972366856 0.106386490780932 no 424 0.122625912750198 723 2894095 SGTC_1472 k841-0093 193 µM 1.1615973935009 0.106457853927419 no 425 0.122699520669608 693 X1472 SGTC_2473 5854593 8.94 µM 1.15939534687102 0.10689230389818 no 426 0.123147536298378 629 2872951 SGTC_3056 9094900 49.47 µM 1.15771838957158 0.107224013968299 no 427 0.123489488442388 630 25236784 SGTC_1773 st048542 73.5835 µM 1.15750625512379 0.107266027989032 no 428 0.123532792597195 660 3237138 SGTC_2114 5491910 81.25 µM 1.15684448792021 0.107397169722737 no 429 0.12366795106027 674 2849228 SGTC_1691 st019933 84.6 µM 1.15483516831249 0.107796062628568 no 430 0.124078966224317 630 6176082 SGTC_53 0973-0023 39.979 µM 1.15459254379041 0.107844300900617 no 431 0.124128660735827 639 674768 SGTC_1603 st002045 67.8 µM 1.14756828671421 0.109247600945224 no 432 0.125573413961751 673 5887985 SGTC_3230 9131665 49.47 µM 1.14437429251644 0.10989001509609 no 433 0.126234222414493 537 15943720 SGTC_316 k060-0003 58.6 µM 1.14326617733824 0.110113524607435 no 434 0.126464046674746 655 6152314 SGTC_1747 st037496 66.6 µM 1.13867025976833 0.11104401328663 no 435 0.127420355785282 699 723305 SGTC_1555 citronellol 128 µM 1.13420475501153 0.111953479505274 no 436 0.128354334958257 643 8842 A terpine precursor. SGTC_2898 9056270 58.44 µM 1.13191652563169 0.112421569749504 no 437 0.128834765143741 603 19154699 SGTC_1842 st055362 61.2 µM 1.12977490847088 0.112860933568971 no 438 0.129285541804302 727 676032 SGTC_1853 st056710 91.2 µM 1.12966950016931 0.112882590233853 no 439 0.129307756782012 692 269167 SGTC_2255 7941087 197.44 µM 1.12899872057052 0.113020474777964 no 440 0.129449186700935 768 935561 SGTC_2278 7948257 134.34 µM 1.12864992372124 0.113092220468439 no 441 0.129522770799627 675 1247028 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.12711162460025 0.113409028301473 no 442 0.129847644532114 654 688803 SGTC_3237 9133362 49.47 µM 1.12558021690332 0.113725045060184 no 443 0.130171622846028 675 43845137 SGTC_2121 5257820 149.641 µM 1.12520738881445 0.113802075676511 no 444 0.130250581416321 737 791256 SGTC_2891 9063876 19.48 µM 1.1233467791997 0.114187055098832 no 445 0.130645121794141 613 6472478 SGTC_3026 9090633 49.47 µM 1.12322108061196 0.114213096847547 no 446 0.130671805815992 689 25236842 SGTC_518 1021-0119 62.6 µM 1.12110719666565 0.114651676974454 no 447 0.131121117852546 660 1097762 SGTC_2737 bleomycin 30.5 nM 1.1210847429075 0.114656342013602 no 448 0.131125896183827 743 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_895 0964-0006 13.7 µM 1.1205760516103 0.114762064963299 no 449 0.13123418181008 689 6738897 SGTC_1615 st002656 86.5 µM 1.11462618400916 0.116003797397189 no 450 0.132505322492214 696 1584458 SGTC_1985 st071382 65.5 µM 1.11162988695854 0.116632720532681 no 451 0.133148658424678 695 6123237 SGTC_946 3434-1334 87.4 µM 1.10765444591918 0.117470892889393 no 452 0.134005540000581 668 4047976 SGTC_826 1683-5028 118 µM 1.10755291493798 0.117492355144812 no 453 0.134027473881075 690 722377 SGTC_824 1304-0008 100 µM 1.10593157168411 0.117835461054987 no 454 0.134378069174682 713 768245 SGTC_968 1309-0633 340 µM 1.1020125505646 0.118667723929165 no 455 0.13522810767088 692 3761976 SGTC_341 1486-1430 230 µM 1.10194842233702 0.118681376967938 no 456 0.135242047715491 689 2054753 YPL210C SRP72 SGTC_2374 9071832 200 µM 1.10040907378934 0.119009440719058 no 457 0.135576963380909 676 17381698 SGTC_1637 st007924 17.4 µM 1.10025417576725 0.119042487786899 no 458 0.135610695942938 700 683336 SGTC_1875 nocodazole 6 µM 1.09881508555378 0.119349823481943 no 459 0.135924365378856 709 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_905 2-aminofluorene 215 µM 1.09806177012332 0.119510926480499 no 460 0.136088758726975 769 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2212 7123476 200 µM 1.0960697780317 0.119937670166979 no 461 0.136524119613872 608 1085715 SGTC_3333 9141820 12.094 µM 1.09325227289403 0.120543095567851 no 462 0.137141525855431 660 1939433 SGTC_1522 st012842 45.6 µM 1.09242587272968 0.120721079869786 no 463 0.137322978003054 645 3491067 YOR116C RPO31 SGTC_2322 7413319 38.22 µM 1.09241990699265 0.120722365400797 no 464 0.137324288491841 809 1840400 SGTC_2641 levomentholum 100 µM 1.09208888828116 0.120793710301053 no 465 0.137397016497822 674 16666 SGTC_2649 anisomycin 9.56 µM 1.09159783949042 0.120899601352541 no 466 0.137504953095489 689 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3002 9075603 71.4286 µM 1.09020496456235 0.12120031994458 no 467 0.137811433472773 728 20105405 SGTC_814 3342-0569 96 µM 1.08906317996523 0.121447220771882 no 468 0.138063012716594 747 4346283 SGTC_519 k048-0011 62.8 µM 1.08894680961139 0.121472404673823 no 469 0.138088671176506 700 6836379 SGTC_1255 0566-0045 221 µM 1.08708848516039 0.121875065234028 no 470 0.138498853117852 716 2788469 SGTC_619 1652-1634 108 µM 1.08538040906274 0.122245996232449 no 471 0.138876602807144 670 5400454 SGTC_880 0833-0487 87.2 µM 1.08498149341801 0.122332740006763 no 472 0.138964925988031 697 76075 SGTC_2355 9061122 103.12 µM 1.08483931657012 0.122363666648622 no 473 0.138996414345201 729 5302957 SGTC_886 0866-0150 153 µM 1.0829411187151 0.122777092862534 no 474 0.139417279594187 764 271463 SGTC_1493 4348-0038 111 µM 1.08235274108393 0.122905439776651 no 475 0.1395479095098 780 800424 SGTC_2630 antimycin a 100 µM 1.08148181395364 0.123095593822914 no 476 0.139741423011395 767 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2030 5175110 200 µM 1.08009374772161 0.123399083597104 no 477 0.14005021788723 720 2831986 SGTC_1734 st037168 69.4 µM 1.07912134414282 0.123612003987672 no 478 0.140266818717879 715 708907 SGTC_547 1120-0019 610 nM 1.07632389451061 0.124225976131625 no 479 0.140891212938559 727 3676939 SGTC_1508 1080-0625 72.9 µM 1.07241842620698 0.125086694379114 no 480 0.141766067667863 695 767111 SGTC_467 ro 31-8220 72.8 µM 1.07232847117509 0.125106568337507 no 481 0.141786261535177 752 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1050 3232-1156 69.3 µM 1.0717444032251 0.125235661367104 no 482 0.141917425441754 711 700529 SGTC_1772 st048439 82.2 µM 1.07017343976683 0.125583343396337 no 483 0.142270623635221 738 2927068 YDL195W SEC31 SGTC_2746 daunorubicin 9.88 µM 1.06907218574941 0.125827471619519 no 484 0.142518571826594 607 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1506 4226-2149 212 µM 1.06825082590556 0.12600976770595 no 485 0.142703691792012 792 991114 SGTC_1988 st071872 53.4 µM 1.06766958869546 0.126138881169626 no 486 0.142834790550284 755 16414116 SGTC_1938 st074717 56.4 µM 1.06309427421129 0.127158441619379 no 487 0.143869600400997 670 17250979 SGTC_1189 1431-2119 7.28 µM 1.06053149605848 0.127732028427585 no 488 0.144451434506581 768 3107275 SGTC_2402 5553605 200 µM 1.06049328767981 0.1277405935992 no 489 0.144460121032051 774 6758546 SGTC_2648 atorvastatin 78.68 µM 1.05851374991231 0.128184892738379 no 490 0.144910642747696 731 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1616 st002734 56.1 µM 1.05804779634537 0.128289629962023 no 491 0.145016826208235 775 4026101 SGTC_718 1130-0073 349 µM 1.0566519669647 0.128603740602102 no 492 0.145335227065365 765 6740020 SGTC_1027 k015-0025 8.67 µM 1.0546908982747 0.129045950980629 no 493 0.145783357909215 736 3598955 SGTC_1114 scopoletin 1.73284 µM 1.05428902511877 0.129136701219836 no 494 0.145875305930764 753 5280460 A coumarin with genotoxic properties. SGTC_1832 st054113 55 µM 1.05399146267983 0.129203924712091 no 495 0.145943412911978 726 1251267 SGTC_2812 7970281 58.44 µM 1.05251703002439 0.129537377423675 no 496 0.146281200674719 759 2233435 SGTC_1903 st060211 78.3 µM 1.0519499566555 0.12966578342899 no 497 0.146411255032485 790 688960 SGTC_520 3584-0023 682 µM 1.05048145531013 0.129998715126854 no 498 0.146748406373533 698 1340790 SGTC_3262 9137218 49.47 µM 1.05037819653999 0.130022147714363 no 499 0.146772133007809 603 17650664 SGTC_3265 9137266 49.47 µM 1.05025416101765 0.130050299050222 no 500 0.146800637093205 721 17224265 SGTC_1353 1498-1206 8.11 µM 1.04951476869261 0.130218200452662 no 501 0.146970630803963 811 6756808 SGTC_2115 tiliquinol 12.7705 µM 1.04769951808069 0.130631043962969 no 502 0.147388534839138 733 71208 A bioactive hydroxyquinoline. SGTC_2661 dactinomycin 12.96 µM 1.04759003982288 0.130655971569773 no 503 0.147413764180226 799 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3152 9099253 49.47 µM 1.0446431368538 0.131328201337764 no 504 0.148093967395569 843 25236131 SGTC_640 3381-0960 37.1 µM 1.04452241201312 0.131355791192538 no 505 0.148121877779195 800 1745025 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.04414299824216 0.131442526581807 no 506 0.148209617386614 711 17037758 SGTC_19 0279-0214 38.434 µM 1.04397587929344 0.131480743131181 no 507 0.148248274748699 838 3566274 YBR002C RER2 SGTC_2084 5306078 60.6385 µM 1.04188006670502 0.131960662210047 no 508 0.148733643411628 736 679340 SGTC_1331 1472-0049 76.2 µM 1.0410846022045 0.132143131152927 no 509 0.148918142581465 718 24051409 SGTC_1411 3909-8223 150 µM 1.03956126962273 0.132493048701284 no 510 0.149271889334817 797 X1411 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.03810924249854 0.13282718084434 no 511 0.149609599492149 811 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3176 9106582 49.47 µM 1.03785079125272 0.132886714940249 no 512 0.149669763077889 613 17018027 SGTC_2894 9048625 32.47 µM 1.03241666262174 0.134142718699549 no 513 0.150938484730367 761 4092861 SGTC_3144 9087057 49.47 µM 1.03160790836682 0.134330342974572 no 514 0.151127917066739 740 17249618 SGTC_575 k072-0246 11.9 µM 1.02941047236832 0.13484103960935 no 515 0.151643415048322 792 6796779 SGTC_2695 st077686 51.995 µM 1.02935346719684 0.134854305637755 no 516 0.151656803464093 731 2876092 SGTC_1872 amphotericin b 148 nM 1.02907566177866 0.134918968280516 no 517 0.151722060971205 810 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2506 ethyl hematommate 54.16 µM 1.02264646172376 0.136421387458985 no 518 0.153237516723423 704 3940691 An allergen. SGTC_2693 st077581 40.7 µM 1.02182933740119 0.136613155173424 no 519 0.15343084072757 866 25238761 SGTC_2667 digitoxin 100 µM 1.01984507705337 0.137079600513079 no 520 0.153900970456117 726 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_872 0588-0139 234 µM 1.01965413947979 0.137124542035979 no 521 0.153946259419544 793 2047100 SGTC_2771 fluoxetine 41.05 µM 1.01860249709549 0.137372250500737 no 522 0.154195859160993 752 3386 A selective serotonin reuptake inhibitor. SGTC_1231 0242-0792 125 µM 1.01268204877509 0.138772479594572 no 523 0.155606027484136 789 3707635 SGTC_2800 7887935 81.82 µM 1.01264458341845 0.138781371264425 no 524 0.155614978210205 753 2961002 SGTC_748 act1.228 77.9 µM 1.01217319780047 0.138893278577683 no 525 0.155727624425243 811 4421505 YNR035C ARC35 SGTC_1706 st031321 9.9705 µM 1.01182596285971 0.138975751714288 no 526 0.155810636950669 827 6103185 SGTC_201 4262-0159 12.803 µM 1.01085489440039 0.13920657097253 no 527 0.156042942541354 724 1341029 SGTC_338 4055-0136 114 µM 1.00551987773194 0.140479336590007 no 528 0.157323291407776 778 2900563 SGTC_1030 k029-0042 36.7 µM 1.00523894747892 0.140546575892234 no 529 0.157390902632389 825 6080581 SGTC_1079 idarubicin 2.36 µM 1.00523224468928 0.140548180439432 no 530 0.157392516019829 773 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_177 1327-0068 8.361 µM 1.00444872045224 0.140735830065114 no 531 0.157581188247609 801 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1906 st060206 94.7 µM 1.00304871982468 0.141071545410275 no 532 0.15791867750663 852 5133468 SGTC_1268 0828-0275 2.46 µM 0.999929156701526 0.141821557923148 no 533 0.158672396542914 842 745337 SGTC_66 0109-0187 42.4 µM 0.999303859935255 0.141972217485476 no 534 0.158823758078121 735 759417 SGTC_2671 danthron 100 µM 0.99922185663456 0.141991983467869 no 535 0.15884361510286 788 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2863 9028737 58.44 µM 0.994208471238697 0.143203943447106 no 536 0.160060692386667 798 6460917 SGTC_1173 0443-0020 122 µM 0.993618929987736 0.14334691976759 no 537 0.160204212320632 791 5331295 SGTC_3150 9097574 49.47 µM 0.99142624938012 0.143879537310758 no 538 0.160738744008805 800 17217476 SGTC_876 0720-0963 56.8 µM 0.987542065338913 0.144826306222536 no 539 0.161688485865191 851 765861 SGTC_1132 3456-3614 2.5 µM 0.987380957228444 0.144865666689131 no 540 0.161727958079212 903 3125502 SGTC_497 capsazepine 133 µM 0.98633107252892 0.145122341357879 no 541 0.161985338363263 798 2733484 A calcium channel blocker. SGTC_1663 st014140 55.4 µM 0.9859473993231 0.145216217681866 no 542 0.162079462765377 942 4207120 SGTC_1138 3761-0006 1.03 µM 0.985843236742999 0.145241711006021 no 543 0.16210502253526 826 12061087 SGTC_217 ketoconazole 989 nM 0.983704081521082 0.145765925604094 no 544 0.162630516210812 809 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2107 5363541 170.161 µM 0.983649895640869 0.145779220718782 no 545 0.162643841605899 854 244052 SGTC_2480 5767542 37.17 µM 0.980050902715161 0.146664099227386 no 546 0.163530496367853 841 2867358 SGTC_2149 5554786 194.827 µM 0.978289905785447 0.147098383215994 no 547 0.163965480471113 852 745063 YPR165W RHO1 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.976465715341235 0.1475491598074 no 548 0.164416864888741 872 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2025 5147754 141 µM 0.976443827532531 0.147554574126872 no 549 0.164422285774944 825 315777 YLR208W SEC13 SGTC_2561 acetosyringone 100 µM 0.976362775609589 0.147574624849062 no 550 0.164442360664061 938 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2122 5258151 111.688 µM 0.975957330773071 0.147674951679802 no 551 0.164542804835781 815 2173356 SGTC_2985 9022375 71.43 µM 0.96999251385484 0.14915621760593 no 552 0.166025111824688 831 4939335 SGTC_1206 3978-0017 132 µM 0.969978520712898 0.149159704202728 no 553 0.166028599351598 779 3873677 SGTC_2105 5350118 200 µM 0.968438607368706 0.149543728821671 no 554 0.166412682962004 838 2133313 SGTC_2520 obtusaquinone 4.71 µM 0.96762934861233 0.149745806568239 no 555 0.166614757228734 835 5967872 SGTC_1980 st071811 45.7 µM 0.967524834652148 0.149771917733634 no 556 0.166640866211056 830 4974850 SGTC_2680 butyl paraben 22.24 µM 0.964649320926621 0.150491510836633 no 557 0.167360243489911 823 7184 An antifungal and steroid mimetic. SGTC_2995 9067767 71.4286 µM 0.96430128056338 0.150578763418315 no 558 0.167447449532385 760 11673567 SGTC_564 3555-0129 330 µM 0.955939987888472 0.152685039756373 no 559 0.169551277367865 764 563260 SGTC_3249 9135183 49.47 µM 0.955939243627912 0.152685228107238 no 560 0.169551465386745 887 4902779 SGTC_662 k832-1615 104 µM 0.954300790015325 0.153100247083195 no 561 0.169965704133483 825 5878478 SGTC_147 4466-0538 29.23 µM 0.950379614678158 0.154096510890401 no 562 0.170959699152341 871 6742687 YHR072W ERG7 SGTC_580 1123-0028 41 µM 0.946212943600356 0.155159838027066 no 563 0.172019992795622 973 1677248 YPR107C YTH1 SGTC_716 1683-5115 658 µM 0.944843316539943 0.155510419760254 no 564 0.172369436858272 950 723597 SGTC_1799 st045822 46.1415 µM 0.944046305827621 0.155714669947144 no 565 0.172572992946097 854 3674992 SGTC_986 1493-0483 84 µM 0.942798376996149 0.156034832262371 no 566 0.172892021026024 840 40079 SGTC_1041 0206-0046 107 µM 0.942697627673494 0.156060698912504 no 567 0.172917793577945 850 50494 SGTC_1263 0774-1208 64.8 µM 0.941413344321641 0.156390676843435 no 568 0.173246538891693 934 906585 SGTC_3295 9122362 53.5725 µM 0.940377093831742 0.156657261055189 no 569 0.173512083736718 807 4730473 SGTC_1438 4092-1045 4 µM 0.939248864188344 0.156947847610705 no 570 0.173801493120537 873 1351342 SGTC_1942 st076330 65.2 µM 0.936992868472516 0.157529964104049 no 571 0.174381113154524 870 24208414 SGTC_2270 7924575 90.91 µM 0.936961165304012 0.157538154595684 no 572 0.174389267207737 887 1262135 SGTC_3039 9090270 49.47 µM 0.936472924774942 0.157664326536741 no 573 0.174514873233186 841 17173750 SGTC_972 1319-0219 195 µM 0.936289615978579 0.157711714641458 no 574 0.174562046562098 849 23903702 SGTC_428 3448-4153 16.5 µM 0.935224437898572 0.157987264459553 no 575 0.174836323448271 777 3834874 SGTC_332 4112-0506 40.9 µM 0.933703096667114 0.158381366430354 no 576 0.175228533601875 872 2790355 SGTC_2275 7947463 200 µM 0.930876246830076 0.159115370241793 no 577 0.175958791419095 844 1225414 SGTC_710 3448-4187 58 µM 0.928295615814974 0.159787384872124 no 578 0.176627123819216 941 3946412 SGTC_2196 6573537 42.6665 µM 0.926882507395494 0.160156153952419 no 579 0.176993770195548 898 2903087 SGTC_1886 st057356 49.9 µM 0.926517056421052 0.160251613631636 no 580 0.177088668644405 831 24207747 SGTC_265 mycophenolic acid 32.932 µM 0.92324853501529 0.161107039546394 no 581 0.177938850523215 929 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3291 9121177 71.43 µM 0.922567492475277 0.161285654015878 no 582 0.178116321420087 783 17015612 SGTC_649 1123-0311 367 µM 0.922336362552396 0.161346300938798 no 583 0.178176576246542 921 693629 YIL048W NEO1 SGTC_3209 9113616 49.47 µM 0.921883659944812 0.161465130119952 no 584 0.178294631580169 929 16649353 SGTC_1071 trifluoperazine 6.31 µM 0.920783926943439 0.161754034903416 no 585 0.178581624108866 911 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3203 9113543 49.47 µM 0.920396515005567 0.161855889944746 no 586 0.178682794572631 832 17018012 SGTC_1565 sinapyl alcohol 95.1 µM 0.916260366220373 0.162945934946465 no 587 0.179765175202813 864 5280507 A phenol propionate derived from cinnamic acid. SGTC_2753 fluvastatin 17.09 µM 0.915748375831693 0.163081196631685 no 588 0.179899442868662 894 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_862 0452-0056 10.2 µM 0.910291690481408 0.164527319170177 no 589 0.181334349808173 885 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2566 crystal violet carbinol 226 nM 0.908908484693311 0.164895210656534 no 590 0.181699217358639 755 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_858 0438-0351 2.77 µM 0.908291738944684 0.165059418229837 no 591 0.181862052981721 942 2799119 SGTC_3107 9121808 49.47 µM 0.907958352993828 0.165148225773869 no 592 0.181950112836116 881 662681 SGTC_2077 5212015 200 µM 0.907656709423104 0.165228604411032 no 593 0.182029811299072 857 780900 SGTC_3269 9137823 49.47 µM 0.906337645983341 0.165580391204074 no 594 0.182378582723109 825 17682936 SGTC_1448 4255-0083 152 µM 0.906100656920064 0.165643646148353 no 595 0.182441288832711 953 5399660 SGTC_3185 9108267 49.47 µM 0.905219909635002 0.165878864053665 no 596 0.18267444813513 908 4910486 SGTC_82 0054-0107 293.755 µM 0.901011950826126 0.167005646031339 no 597 0.183790982784422 929 3104697 SGTC_63 0099-0242 26.702 µM 0.900459184133628 0.167154028523617 no 598 0.18393796846947 968 3898502 YLR359W ADE13 SGTC_1179 1021-1431 9.29 µM 0.899126743568176 0.167512052821788 no 599 0.18429257730672 941 2840958 SGTC_659 k018-0002 107 µM 0.89866442365308 0.167636392681987 no 600 0.184415716077647 932 6797879 YHR007C ERG11 SGTC_885 0865-0106 16.8 µM 0.897636492885799 0.167913065218154 no 601 0.184689688494303 920 2793380 SGTC_644 1498-1197 63.3 µM 0.892819120384585 0.169213598270001 no 602 0.185977022628052 967 6741615 SGTC_157 1348-1695 65.819 µM 0.892334709609262 0.169344730245343 no 603 0.186106777613698 907 5380510 SGTC_2739 tacrine 100.86 µM 0.892131697392819 0.169399705872083 no 604 0.186161173448157 889 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_192 3455-0609 60.9 µM 0.891365060464171 0.169607414127777 no 605 0.186366677797808 914 3769639 SGTC_3047 9092122 49.47 µM 0.891254658840321 0.169637339169298 no 606 0.186396283579695 881 17173831 SGTC_2148 5546263 113.568 µM 0.89122533536203 0.169645288048296 no 607 0.186404147581423 920 792097 SGTC_3251 9135047 49.47 µM 0.888070739195434 0.170501817307312 no 608 0.187251350580347 912 17682963 SGTC_2828 7998861 71.43 µM 0.887489299066756 0.170659990421938 no 609 0.187407762461103 859 2988188 SGTC_2248 tofa 1.1 µM 0.881189220197965 0.172379863350729 no 610 0.189107706437523 905 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_542 3381-0244 89.3 µM 0.879723577145874 0.172781552422555 no 611 0.189504536875168 988 1112843 SGTC_368 fentichlor 4.58 µM 0.877729085530122 0.173329140653305 no 612 0.190045378188059 860 7329 A pesticide. SGTC_2834 9001755 58.44 µM 0.87659207603723 0.173641800850981 no 613 0.190354122342543 858 2989575 SGTC_228 caffeine 993.056 µM 0.875809098814396 0.17385731610111 no 614 0.190566911399509 900 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1229 0139-0193 12.2 µM 0.875400853607354 0.173969753438719 no 615 0.190677917750912 993 3090752 SGTC_1141 3253-0389 52.6 µM 0.875166021240344 0.174034451015389 no 616 0.190741789224953 948 5402031 SGTC_2870 9038528 12.99 µM 0.874429415027383 0.174237489202546 no 617 0.190942222094666 830 6463316 SGTC_1818 st052136 56.3 µM 0.873436065511699 0.174511534399683 no 618 0.191212720126297 893 674169 SGTC_2292 7671323 168.05 µM 0.873098347673014 0.174604766296191 no 619 0.191304737224395 919 937504 SGTC_1556 plumbagin 1.48 µM 0.872073154872789 0.174887979296619 no 620 0.19158423504116 895 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_206 4546-0025 72.014 µM 0.869921414561509 0.175483352348132 no 621 0.192171675871154 980 6620745 YIL048W NEO1 SGTC_3162 9099653 49.47 µM 0.867356268709233 0.176194788647916 no 622 0.192873417509243 929 25237511 SGTC_1631 benzylvanillin 81.9 µM 0.867084841694704 0.176270174854918 no 623 0.192947762701004 929 75506 SGTC_2013 4024628 200 µM 0.866904545996758 0.176320261507598 no 624 0.192997156250382 899 5230760 SGTC_1613 st002381 52.1 µM 0.866390494485456 0.176463115899432 no 625 0.193138027447724 1006 551167 SGTC_1355 1499-0035 1.68 µM 0.865793858763567 0.176629012132507 no 626 0.193301608791153 917 1548538 SGTC_2857 9024691 58.44 µM 0.864499418138963 0.176989273934131 no 627 0.19365679991688 937 16478292 SGTC_3084 9116877 49.47 µM 0.863881424094366 0.177161434369392 no 628 0.19382651613578 894 27241325 SGTC_1709 st033179 39.1045 µM 0.862932277273667 0.177426053068243 no 629 0.194087351458286 969 573381 SGTC_3233 9132340 49.47 µM 0.862434801342633 0.177564847169313 no 630 0.194224148337923 942 17682950 SGTC_604 1000-0114 314 µM 0.860127498404914 0.178209472440559 no 631 0.194859382291531 1013 1572745 SGTC_2181 6316240 54.2555 µM 0.858734608132693 0.178599337815613 no 632 0.195243476085482 917 12779990 SGTC_1363 1636-0063 10.4 µM 0.855341231031028 0.179551378963108 no 633 0.196181134052028 990 6072185 SGTC_2809 7964133 12.99 µM 0.854535673690143 0.179777852629532 no 634 0.196404126067918 939 1253665 SGTC_2670 beta-carotene 100 µM 0.85420586125178 0.179870627555719 no 635 0.19649546808454 923 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_852 0418-0143 439 µM 0.85221371537169 0.180431649450034 no 636 0.197047742812924 1039 5369229 SGTC_2608 thymoquinone 42.66 µM 0.850847391764993 0.180817063167938 no 637 0.197427065862893 923 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2211 7117706 200 µM 0.849173067908642 0.18129006095055 no 638 0.197892498527215 950 822771 SGTC_2532 xanthone 78.9 µM 0.844119453000482 0.182722404119838 no 639 0.199301329172724 889 7020 An insecticide. SGTC_2517 totarol 10 µM 0.84404983034109 0.182742186441257 no 640 0.199320780437713 931 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2204 7233102 200 µM 0.843318796876908 0.182949980267295 no 641 0.199525086482094 925 2172480 SGTC_687 k029-0044 34.9 µM 0.842633173641951 0.183145000321361 no 642 0.1997168159701 1030 5829338 SGTC_2456 5770359 74.46 µM 0.84099089757302 0.183612659689318 no 643 0.200176516882676 1009 3118787 SGTC_2403 6032726 181.2 µM 0.840501911533466 0.183752048437889 no 644 0.200313515131794 954 2881040 SGTC_418 lividomycin a 100 µM 0.837391903290387 0.184640119292015 no 645 0.201186157703232 1033 72394 An antibiotic. SGTC_439 amiodarone 34.4 µM 0.836551873233356 0.184880449055818 no 646 0.201422253622611 988 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_126 0417-1624 672.48 µM 0.836032245944987 0.185029209946218 no 647 0.201568381346494 1135 41912 YDL195W SEC31 SGTC_2277 7947813 106.88 µM 0.835948838412599 0.185053095098559 no 648 0.201591842828084 944 1246798 SGTC_1728 st035614 33.7865 µM 0.835796731118531 0.185096658516817 no 649 0.201634632893714 1009 15945546 SGTC_2426 5582046 32.21 µM 0.83552084441998 0.185175688520599 no 650 0.201712257846342 985 2251934 SGTC_1047 2043-3044 82 µM 0.832558189460019 0.186025685710062 no 651 0.202546973797568 1051 669592 SGTC_1755 st041960 45.185 µM 0.83091961554533 0.186496836087262 no 652 0.203009520814335 985 2257073 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.83069184281386 0.18656238759693 no 653 0.203073867840938 1105 688801 SGTC_2476 5806916 10.51 µM 0.827489826790909 0.187485416516923 no 654 0.203979742929016 959 2870194 SGTC_3124 9127567 49.47 µM 0.827138552528088 0.187586848079247 no 655 0.204079267481751 975 17592030 SGTC_1686 st019653 115.5 µM 0.82693131193805 0.187646705359418 no 656 0.204137997352322 1017 97252 SGTC_2485 5633444 17.78 µM 0.826475236759078 0.187778475063052 no 657 0.204267279857723 962 5724239 SGTC_2880 9042983 58.44 µM 0.825048279922177 0.188191121883969 no 658 0.204672090565084 981 6464714 SGTC_62 0180-0423 3.232 µM 0.824086401688263 0.188469592927383 no 659 0.204945233074467 1002 30102 YGL099W LSG1 SGTC_908 3448-7491 47.7 µM 0.822139058706286 0.18903414099937 no 660 0.20549887895724 1045 1203031 SGTC_21 0849-0113 22.993 µM 0.817406537513527 0.190410466895257 no 661 0.206848070455268 1013 1560156 SGTC_258 haloperidol 50.781 µM 0.816112335613722 0.190787919475127 no 662 0.207217944654413 1000 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1040 k898-0338 155 µM 0.815187035035995 0.191058063652734 no 663 0.207482628977929 1080 20969351 SGTC_1458 k015-0034 6.33 µM 0.815110786524444 0.191080335082611 no 664 0.207504448945365 981 3598957 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.814867791378298 0.191151322162385 no 665 0.207573995693664 987 5282362 SGTC_270 tamoxifen 5.46 µM 0.814320664066728 0.191311215688516 no 666 0.207730637405175 1078 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1475 4092-1048 11.7 µM 0.812989770695469 0.191700500597493 no 667 0.208111961531567 1036 2881759 SGTC_12 0849-0099 9.267 µM 0.810864362183762 0.192323185406215 no 668 0.208721784028221 995 6071388 SGTC_2177 5811945 192 µM 0.809920235328777 0.192600184296938 no 669 0.208993010497666 1044 5343475 SGTC_1418 3966-3099 2.4 µM 0.808398726256565 0.193047095083622 no 670 0.209430542491904 1042 740335 SGTC_44 0929-0055 61.211 µM 0.808271525517309 0.193084486242749 no 671 0.209467145304756 980 1379590 SGTC_1786 berberine 21.6 µM 0.8061105422133 0.19372039127701 no 672 0.210089556740829 977 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1963 st076565 50.3 µM 0.804337081701742 0.194243214086688 no 673 0.210601163732136 1045 4914280 SGTC_339 3091-4833 71.4 µM 0.801008659395734 0.195226762397174 no 674 0.211563316386806 1032 3240077 SGTC_2795 7780010 54.55 µM 0.798912701140512 0.195847667788704 no 675 0.212170516847464 982 953673 SGTC_1763 st044482 94.5 µM 0.797548323353742 0.196252493415666 no 676 0.212566324842693 1036 88505 SGTC_1881 5652484 16 µM 0.796699680664167 0.196504550600564 no 677 0.212812734729518 1008 2255129 SGTC_3137 9097352 49.47 µM 0.79664412476489 0.196521058215788 no 678 0.212828871622087 1114 44120435 SGTC_1712 st032288 53.4 µM 0.796123608004551 0.196675762899749 no 679 0.212980096792268 1088 2883011 SGTC_2524 avocatin b 10.57 µM 0.796090667516776 0.196685555743504 no 680 0.212989669065476 996 6710748 SGTC_2315 7733312 200 µM 0.794972308753962 0.197018206677392 no 681 0.213314805135779 1000 726316 SGTC_3132 9126706 49.47 µM 0.79444887305803 0.19717401725879 no 682 0.213467080911179 1001 850858 SGTC_369 0957-0393 4.5 µM 0.794046876314513 0.197293729829896 no 683 0.213584071162463 1040 6997992 SGTC_1155 4088-0394 48.2 µM 0.793715335406721 0.197392494088481 no 684 0.213680585257871 1020 2326248 SGTC_2368 9071271 200 µM 0.793243120412583 0.197533216013372 no 685 0.213818094509405 1029 27209959 SGTC_2933 9026794 32.47 µM 0.792991573635395 0.197608202695342 no 686 0.213891366093491 1021 17586027 SGTC_565 1418-0001 44.5 µM 0.792714337988185 0.197690867218916 no 687 0.213972137370302 1078 2862145 SGTC_353 1988-1175 58.3 µM 0.790860487855743 0.198244174477892 no 688 0.214512703872545 960 2788357 SGTC_695 3505-6186 243 µM 0.790826710881832 0.198254264346886 no 689 0.214522560302135 1055 1819379 SGTC_576 1073-0113 22.7 µM 0.789988925577871 0.198504627035289 no 690 0.214767117950901 1248 5439563 SGTC_1073 triclabendazole 3.09 µM 0.788541466279124 0.198937633095851 no 691 0.215190026834174 1084 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2167 5876490 200 µM 0.788439737398517 0.198968086587347 no 692 0.215219767460272 1059 686534 SGTC_1628 st004252 77.7 µM 0.788218595196256 0.199034297263933 no 693 0.215284427020602 1055 692968 SGTC_746 1095-0025 46.6 µM 0.787988690746669 0.199103145458587 no 694 0.215351660516617 1071 6749286 SGTC_2080 5212524 12.4 µM 0.787944971103258 0.199116239558163 no 695 0.215364447313059 1034 260183 SGTC_2518 prenyletin 46.28 µM 0.786834851630344 0.199448895824667 no 696 0.215689274377985 979 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.785541552981005 0.199836864840261 no 697 0.21606805864304 1129 5024745 SGTC_2129 girgensonine 121.053 µM 0.785364405934657 0.199890041457603 no 698 0.216119971860677 1096 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3188 9110789 49.47 µM 0.785257349128582 0.19992218226752 no 699 0.216151348525901 1059 849217 SGTC_2112 5488546 200 µM 0.785023028833779 0.199992541222507 no 700 0.216220033322155 1062 600757 SGTC_2142 5622915 118.518 µM 0.78479503842715 0.200061013800823 no 701 0.216286874807261 1058 5322196 SGTC_2813 7971799 71.43 µM 0.778224455466427 0.202040413384496 no 702 0.218218351012209 1031 2234054 SGTC_218 alverine citrate 93.75 µM 0.777168409947031 0.202359638673127 no 703 0.218529708629548 1034 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2312 7706453 155.7 µM 0.774372580154193 0.203206227417272 no 704 0.219355246908473 1048 976098 SGTC_1671 st016596 74.5 µM 0.772551399727557 0.203758823613026 no 705 0.219893958228047 1146 2829167 SGTC_2300 7976697 71.57 µM 0.771885782080528 0.203961013631663 no 706 0.220091039479059 971 2236109 SGTC_1422 4031-0024 15.5 µM 0.770797477726589 0.204291857649933 no 707 0.220413491262765 1071 782427 SGTC_849 0386-0493 241 µM 0.770461481041781 0.204394065004636 no 708 0.220513097806333 1050 726119 SGTC_2090 5301565 104.445 µM 0.7693584905211 0.204729799315822 no 709 0.220840261676749 1100 2056344 SGTC_2645 abamectin 100 µM 0.768743023392759 0.204917281080706 no 710 0.221022939388953 1085 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1825 st052143 62.6 µM 0.768676771896282 0.204937468498076 no 711 0.221042608748388 1059 674173 SGTC_3119 9125183 49.47 µM 0.767045145880381 0.205435012424816 no 712 0.221527337057958 958 22695334 SGTC_2882 9058044 58.44 µM 0.76458849364714 0.206185489394641 no 713 0.222258311490681 1079 18076804 SGTC_2915 7971052 15.16 µM 0.764501883874795 0.206211977238371 no 714 0.222284107232891 967 5741558 SGTC_2743 auranofin 4.32 µM 0.762743670984135 0.206750127009397 no 715 0.222808140258927 1051 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2629 bisabolol 100 µM 0.76260682758382 0.206792046571111 no 716 0.222848955758761 1093 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2041 5107442 45.335 µM 0.762374448800144 0.206863243238156 no 717 0.222918275810258 1113 793005 SGTC_650 1328-0195 38 µM 0.761444965406018 0.20714816522759 no 718 0.223195669342625 1097 2780821 SGTC_2141 5621638 7.665 µM 0.759667681596688 0.207693616117398 no 719 0.223726625779838 1090 2856238 SGTC_1395 3486-0190 4.35 µM 0.759631831427016 0.207704627307742 no 720 0.223737343258091 1142 6748079 SGTC_1847 st056231 15 µM 0.756860623814644 0.208556832310697 no 721 0.224566684022337 1149 5393180 SGTC_2861 9024595 19.48 µM 0.756406786951595 0.208696592943448 no 722 0.224702670028154 1050 16482810 SGTC_3065 9113888 49.47 µM 0.756280410545825 0.208735520818757 no 723 0.224740545300252 1085 16648368 SGTC_1024 4507-0395 26 µM 0.754302119228167 0.209345453866047 no 724 0.225333915050514 1089 4201836 SGTC_363 0455-0021 3.06 µM 0.753159849494333 0.20969810767755 no 725 0.225676931636451 1113 4597466 SGTC_2980 9014342 25.29 µM 0.751899121141436 0.210087738560217 no 726 0.226055863350837 1074 2996599 SGTC_617 3770-0098 35 µM 0.751847489018043 0.210103704642627 no 727 0.226071389858864 1066 5962639 SGTC_2564 betulinic acid 100 µM 0.751835309389269 0.21010747102504 no 728 0.22607505253295 1139 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1133 3473-0247 50 µM 0.751050521712676 0.210350239407506 no 729 0.226311125616579 1061 711311 SGTC_1828 st055811 49 µM 0.750912551566614 0.210392936488288 no 730 0.226352642997674 1073 5877589 SGTC_991 3996-0057 64.7 µM 0.750356444452462 0.210565084354221 no 731 0.226520027958358 1051 715343 SGTC_2946 9065502 71.43 µM 0.750034310740033 0.210664841485159 no 732 0.22661702026166 944 16489101 SGTC_2151 5563267 85.4165 µM 0.749709228199247 0.21076553990181 no 733 0.22671492419749 1095 5310824 SGTC_599 1935-0052 86.5 µM 0.748901343012428 0.211015914760385 no 734 0.22695833539943 1131 9557311 SGTC_3091 9116372 49.47 µM 0.748073429630895 0.211272677437371 no 735 0.227207933819775 1096 17169793 SGTC_2486 5283202 22.39 µM 0.746338626121636 0.211811289239477 no 736 0.227731441877482 1083 1377751 SGTC_1606 st000094 49.2 µM 0.746028823441195 0.211907559471052 no 737 0.227825001786528 1165 1242210 SGTC_3224 9130643 49.47 µM 0.745445376160904 0.21208893339988 no 738 0.228001260635313 1137 17644395 SGTC_256 clotrimazole 625 nM 0.745158987251265 0.212177995181474 no 739 0.228087806500368 1097 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2273 7815444 169.05 µM 0.744831924803908 0.212279732436467 no 740 0.228186666378311 1106 2824616 SGTC_141 0443-0274 32.331 µM 0.744104568733596 0.212506088688501 no 741 0.228406607770061 1236 1627241 SGTC_747 3448-8087 38.7 µM 0.74357133252652 0.212672123562383 no 742 0.228567925920431 1138 5168703 SGTC_981 1488-1094 54.9 µM 0.743182772691722 0.212793157946806 no 743 0.228685515910771 1102 3449522 SGTC_684 1140-0066 328 µM 0.74096769488726 0.213483910848586 no 744 0.229356514045187 1146 6813534 SGTC_1000 4048-0884 8.67 µM 0.73966283182573 0.213891432050015 no 745 0.229752303136116 1088 13040088 SGTC_505 gw-5074 63.9 µM 0.738635570929626 0.21421257385047 no 746 0.230064159244599 1108 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_115 0527-0192 112.043 µM 0.738410704963438 0.214282908744811 no 747 0.230132455693466 1147 4233931 SGTC_253 dyclonine 31.25 µM 0.738234530191495 0.21433802310625 no 748 0.23018597154215 1184 3180 An oral anasthetic. SGTC_1564 D-Arginine 115 µM 0.737303980020049 0.214629272362069 no 749 0.230468756207135 1115 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2759 disulfiram 3.38 µM 0.737238676335797 0.214649720140554 no 750 0.23048860861725 1114 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_329 k048-0121 21.3 µM 0.736738209799682 0.214806462952846 no 751 0.230640782862562 1125 6832902 SGTC_349 k015-0014 24 µM 0.735597020887932 0.215164124367473 no 752 0.230987988064768 1109 2196908 SGTC_2381 9035592 200 µM 0.735498194981164 0.215195113771784 no 753 0.23101806943676 1071 4749657 SGTC_2401 5128683 200 µM 0.734864104686907 0.215394010716645 no 754 0.231211130622229 1110 708373 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.73400379991379 0.215664035453945 no 755 0.231473211081025 1128 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1611 st001856 99.4 µM 0.733532970055923 0.215811898361957 no 756 0.23161671326206 1118 647478 SGTC_3197 9113331 49.47 µM 0.733144640080706 0.215933896596579 no 757 0.231735107966113 1140 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_79 0052-0007 94.094 µM 0.730816503828538 0.216666144245757 no 758 0.2324456207341 1150 2801472 SGTC_3118 9124250 49.47 µM 0.730671234797235 0.216711881954842 no 759 0.232489994816831 1036 1504786 SGTC_2997 9067075 71.4286 µM 0.730395603897646 0.21679867922461 no 760 0.232574202366209 1146 27209819 SGTC_1672 st016598 6.51 µM 0.72822808802664 0.217481938816426 no 761 0.233236987278514 1080 4665860 YNL267W PIK1 SGTC_2825 7998094 58.44 µM 0.728193039793266 0.217492997169596 no 762 0.233247712963847 1103 2987815 SGTC_2949 9072542 2.23 µM 0.727820934172244 0.217610423254963 no 763 0.233361603994408 1182 16457352 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.727746638564046 0.21763387324367 no 764 0.23338434747843 1200 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_343 4130-2827 29.8 µM 0.726117939740852 0.218148307143739 no 765 0.233883236088841 1159 1118244 SGTC_1170 0310-0127 64.8 µM 0.726102929430842 0.218153051493434 no 766 0.233887836660568 1137 774975 SGTC_925 2064-1272 59.6 µM 0.725736742786285 0.218268811526185 no 767 0.23400008624463 1087 6815817 SGTC_1978 st071761 42 µM 0.720617057823221 0.21989096423589 no 768 0.235572577954712 1101 5147680 SGTC_837 0091-0265 12.5 µM 0.720242042712995 0.220010057688401 no 769 0.23568799111805 1131 759367 SGTC_2095 5432005 200 µM 0.719959342763547 0.220099859096929 no 770 0.235775014343936 1158 783734 SGTC_1850 st056238 17 µM 0.719056907483291 0.22038666395432 no 771 0.236052928550166 1182 5393177 SGTC_3104 9120930 49.47 µM 0.718084022924057 0.220696098268459 no 772 0.236352740403386 1152 17014836 SGTC_1009 4106-0057 9.87 µM 0.717020594718464 0.221034615258541 no 773 0.23668069458574 1193 2928005 SGTC_444 curcumin 90.4 µM 0.715105995999121 0.221644830571409 no 774 0.237271774604939 1109 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3139 9095020 49.47 µM 0.714997419828373 0.221679464471834 no 775 0.237305318804372 989 25236292 SGTC_2389 9091542 195.52 µM 0.714192242532428 0.221936398429009 no 776 0.23755415655092 1126 3626624 YOL127W RPL25 SGTC_303 1348-1668 34.2 µM 0.713435014749247 0.222178186671618 no 777 0.237788306242285 1169 5380509 SGTC_3093 9117344 49.47 µM 0.712019752963099 0.222630492682988 no 778 0.238226272147218 1118 24824913 SGTC_223 busulfan 5 mM 0.71192402820004 0.222661104469699 no 779 0.238255911012082 1133 2478 A DNA alkylator. SGTC_1264 0783-0040 158 µM 0.711700812303846 0.222732495918584 no 780 0.238325032278921 1108 2855798 SGTC_27 0485-0001 32.618 µM 0.711117602513004 0.222919086269972 no 781 0.238505681455285 1114 2054479 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.710656930440818 0.223066535204758 no 782 0.238648427559802 1156 6708760 SGTC_842 0271-0008 11.1 µM 0.710605164019697 0.223083107736115 no 783 0.238664471078078 1191 1221709 SGTC_2263 7948595 193.29 µM 0.70971485733557 0.223368240718204 no 784 0.238940488454647 1128 2971371 SGTC_152 4469-0003 551.229 µM 0.708168206450254 0.223864069687049 no 785 0.239420403703027 1162 697280 SGTC_2199 6590217 200 µM 0.706408524299311 0.224428952646563 no 786 0.239967060655479 1125 703109 SGTC_1036 k216-0215 33.5 µM 0.703579333181696 0.225338856827362 no 787 0.240847392739842 1187 622330 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.702767026473332 0.225600490553978 no 788 0.241100474647239 1203 688788 SGTC_431 k089-0097 107 µM 0.702067198511889 0.225826034074899 no 789 0.241318628615946 1160 5499420 SGTC_1669 st015249 58.4 µM 0.700885140498321 0.226207282199939 no 790 0.241687349264243 1263 722793 SGTC_1327 1436-0082 2.18 µM 0.697997541687313 0.227140144530027 no 791 0.24258936572496 1154 15992205 SGTC_651 3253-0966 34.4 µM 0.69767147667898 0.227245618580632 no 792 0.242691335019799 1217 781462 SGTC_1285 0929-0069 65.5 µM 0.696321388305963 0.227682632751179 no 793 0.243113790785637 1187 1206237 SGTC_1961 st076550 68.7 µM 0.695787256916067 0.227855657872627 no 794 0.243281035401751 1166 1579337 SGTC_3328 9140624 29.0385 µM 0.694289125254421 0.228341353286529 no 795 0.243750454714831 1203 4904392 SGTC_645 0845-0943 5.41 µM 0.693265789245293 0.228673453776009 no 796 0.244071384072956 1180 1885106 SGTC_672 1441-0018 53.7 µM 0.692316024351229 0.228981920953505 no 797 0.244369444517808 1178 251141 SGTC_93 0109-0045 59.227 µM 0.691167398775059 0.229355286352586 no 798 0.244730174423926 1279 88733 SGTC_1705 st027868 56.3335 µM 0.690122298106284 0.229695296867966 no 799 0.24505864090065 1214 292948 SGTC_2926 9010726 65.15 µM 0.689389079986984 0.229934008681234 no 800 0.245289226746907 1205 2994293 SGTC_2713 st079149 53.4 µM 0.689048908347376 0.230044804568271 no 801 0.245396245102346 1223 3103253 SGTC_2174 5790901 200 µM 0.688772923348304 0.230134716438897 no 802 0.245483088706992 1214 786020 SGTC_3278 9139605 49.47 µM 0.688618810216255 0.230184932793362 no 803 0.245531590337894 1226 7958859 SGTC_928 2764-0428 58.7 µM 0.688059427724574 0.230367253952185 no 804 0.245707679341667 1203 662578 SGTC_958 1222-0007 33 µM 0.687453368173236 0.230564879797759 no 805 0.245898538407039 1261 7312461 SGTC_187 1488-2104 32.728 µM 0.686099415777692 0.231006723017858 no 806 0.246325209658849 1240 2852859 SGTC_1928 4'-methoxychalcone 40.3 µM 0.685188598504716 0.23130422108287 no 807 0.246612458790814 1235 641818 SGTC_729 4092-0585 94.1 µM 0.683311802575352 0.231917907771382 no 808 0.24720491889098 1203 2169061 SGTC_3019 9081971 49.47 µM 0.683266286409052 0.231932802190943 no 809 0.247219296715759 1263 16451803 SGTC_1415 3966-0071 78.1 µM 0.682800729765207 0.232085178559611 no 810 0.247366384245293 1207 2893185 SGTC_2625 euphol 100 µM 0.68135351158511 0.232559207762022 no 811 0.247823915554185 1204 6708538 A triterpene alcohol. SGTC_2741 miltefosine 3.04 µM 0.679021763708682 0.233324091436102 no 812 0.248562036106105 1144 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2010 4012422 159 µM 0.678595367830084 0.23346411297434 no 813 0.248697139333749 1192 952393 SGTC_280 3448-3607 3.04 µM 0.678415515180268 0.23352318766108 no 814 0.248754137241014 1209 626179 SGTC_1376 2910-0861 41.3 µM 0.677658011369473 0.233772089533491 no 815 0.248994277483369 1227 1112859 SGTC_960 1222-0186 7.7 µM 0.676879483448218 0.234028052688786 no 816 0.249241211171406 1220 3126296 SGTC_2674 ligustilide 100 µM 0.676013555455563 0.234312933358425 no 817 0.24951601933265 1197 5319022 A signalling regulator. SGTC_532 1548-0774 215 µM 0.675882483326095 0.234356071348929 no 818 0.249557629992558 1320 5932993 SGTC_1450 4112-4260 37.6 µM 0.675323493883224 0.234540093288534 no 819 0.249735130301219 1217 1633175 SGTC_2586 curcumin 80 µM 0.675028079741959 0.234637377279026 no 820 0.249828962543736 1239 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2886 9058944 51.95 µM 0.672266667242477 0.23554782726848 no 821 0.250706973001381 1099 4949929 SGTC_1561 5-methoxyflavone 52.9 µM 0.671367416366567 0.235844734440343 no 822 0.250993248444764 1197 94525 SGTC_2435 5706476 10.6 µM 0.670969784908591 0.235976086842013 no 823 0.251119889077164 1245 5725375 SGTC_3214 9129694 49.47 µM 0.669941462968453 0.236315966546527 no 824 0.251447553387115 1209 17158655 SGTC_1732 st034308 51.822 µM 0.668037049557137 0.236946122131525 no 825 0.25205497151085 1166 830119 SGTC_2217 6934799 96.0675 µM 0.66697257022825 0.237298752103598 no 826 0.252394827229467 1188 675606 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.666768663212441 0.237366333239163 no 827 0.252459956061607 1115 88881 An O-methylated flavonoid and antioxidant. SGTC_800 3448-7362 155 µM 0.666215127104804 0.237549845617643 no 828 0.252636802667186 1317 15991913 SGTC_740 k014-0057 261 µM 0.665108830369947 0.237916846492228 no 829 0.252990443550763 1253 4012779 SGTC_1194 1488-0194 225 µM 0.664133562244715 0.238240637831921 no 830 0.253302415479202 1222 1391452 SGTC_1470 k295-0292 231 µM 0.664046709294774 0.238269484920015 no 831 0.253330208086768 1283 5045612 SGTC_562 3772-2733 112 µM 0.664038903657518 0.238272077555545 no 832 0.253332705938962 1248 2876874 YIL048W NEO1 SGTC_2099 5377090 177.372 µM 0.662806535112015 0.238681601440815 no 833 0.253727233824083 1242 2243829 SGTC_38 0929-0051 58.268 µM 0.661729596133354 0.239039790205656 no 834 0.254072266788403 1248 1379719 SGTC_219 mitoxanthrone 164.414 µM 0.65981906355873 0.239675953739445 no 835 0.254684974092409 1243 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2978 9011784 42.97 µM 0.659173777774482 0.239891027661048 no 836 0.254892091742051 1316 2994934 SGTC_458 nppb 133 µM 0.658446024879129 0.240133714145552 no 837 0.255125784621516 1296 4549 A chloride channel blocker. SGTC_2467 5474540 200 µM 0.657955839273176 0.240297253573343 no 838 0.255283254050017 1238 5413519 SGTC_2358 9037157 4 µM 0.656294141536105 0.24085209299045 no 839 0.255817443134357 1278 2388925 SGTC_1713 st033146 12.748 µM 0.656030294505394 0.240940255357685 no 840 0.255902316178619 1270 674619 SGTC_840 0245-0196 390 µM 0.655781518310209 0.241023398001111 no 841 0.255982354766274 1318 3827528 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.654323309935264 0.241511054442663 no 842 0.256451765619337 1270 5379071 SGTC_289 k017-0060 526 µM 0.652926070318519 0.241978823859179 no 843 0.256901970454904 1233 5512909 SGTC_502 l-744,832 89.3 µM 0.652598992461728 0.242088394282557 no 844 0.257007417642889 1233 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2353 9059630 146.67 µM 0.651051629431172 0.242607122290014 no 845 0.257506579687595 1275 4779114 SGTC_2076 5212012 200 µM 0.650041838596824 0.242945962327292 no 846 0.257832598279265 1179 604802 SGTC_2493 resveratrol 26.09 µM 0.649625412749349 0.243085770492468 no 847 0.257967106860845 1203 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1115 galangin 695.678 nM 0.648637602924103 0.243417585424753 no 848 0.258286322155716 1304 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_669 0108-0021 26.2 µM 0.6479251886225 0.243657044128513 no 849 0.258516669116396 1388 17201 SGTC_1839 st053978 48 µM 0.647129461395475 0.243924656512465 no 850 0.258774079614796 1308 3788398 SGTC_1974 st069448 26.9 µM 0.646631114025463 0.244092337296598 no 851 0.258935357967586 1243 6323587 YNR016C ACC1 SGTC_1618 st003135 44.5 µM 0.646096030887894 0.244272447887327 no 852 0.259108582851627 1225 1270615 SGTC_2768 sulfasalazine 50.2 µM 0.644404354381619 0.244842342249756 no 853 0.259656630823699 1343 5384001 An antioxidant and salicylic acid derivative. SGTC_408 cantharidin 100 µM 0.643526859329454 0.245138235647233 no 854 0.259941146090324 1271 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.642553121877647 0.245466807179164 no 855 0.260257054692935 1375 6728940 SGTC_135 0933-0004 26.348 µM 0.641393975608087 0.245858250136826 no 856 0.260633373040364 1252 21230617 YGL099W LSG1 SGTC_2958 9077254 16.72 µM 0.640530932134937 0.246149916821821 no 857 0.260913743017855 1292 16457351 SGTC_57 miconazole 162.5 nM 0.640321332749447 0.246220779207444 no 858 0.260981857283413 1214 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1097 itavastatin 7.23 µM 0.638636232898716 0.246790883274511 no 859 0.261529802295851 1307 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_283 0987-0079 11.7 µM 0.637613471423198 0.247137248918404 no 860 0.261862662087258 1292 411556 SGTC_548 1436-0017 110 µM 0.63604921207821 0.247667499295738 no 861 0.262372173400102 1345 9677137 SGTC_24 0417-1663 219 µM 0.63434950906381 0.24824435026416 no 862 0.262926376429421 1273 4329390 SGTC_3179 9107801 49.47 µM 0.633827512924821 0.24842165076971 no 863 0.26309669787899 1279 4818259 SGTC_3302 9125395 16.351 µM 0.633698984142305 0.248465317035283 no 864 0.263138644018659 1282 17599668 SGTC_3040 9091894 49.47 µM 0.633645691781125 0.248483423738863 no 865 0.263156037302651 1229 25236966 SGTC_2049 5262831 67.185 µM 0.63351319849799 0.248528442929741 no 866 0.263199282317387 1318 763417 SGTC_608 k048-0125 159 µM 0.633447812370111 0.248550661737218 no 867 0.263220625296007 1322 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2318 6029776 164 µM 0.633307663589534 0.248598289146477 no 868 0.263266374864671 1341 818325 SGTC_3031 9088762 49.47 µM 0.632753690479103 0.248786595972949 no 869 0.263447251221887 1243 205253 SGTC_2257 7960413 200 µM 0.631396215395105 0.249248350474116 no 870 0.263890744987734 1277 2974689 YIL048W NEO1 SGTC_1731 st035964 63 µM 0.629804201587136 0.249790465021722 no 871 0.264411348183636 1322 6739575 SGTC_3131 9127911 49.47 µM 0.629503039870837 0.249893087357997 no 872 0.264509889607577 1336 45595681 SGTC_319 1348-1596 45.5 µM 0.628065896646369 0.25038310901691 no 873 0.264980386338633 1365 5380505 SGTC_780 0109-0199 192 µM 0.627800902222694 0.250473519553552 no 874 0.265067187506043 1357 610414 SGTC_208 k072-0098 12.366 µM 0.626903392326488 0.250779859574693 no 875 0.265361281738578 1298 5948901 SGTC_782 0083-0095 30.5 µM 0.626557011350347 0.250898140111841 no 876 0.265474827432693 1307 3591729 An indicator and reagent. SGTC_2976 9009005 19.48 µM 0.62631547174225 0.250980637385817 no 877 0.265554020103268 1325 2993148 SGTC_2363 9053361 176 µM 0.625929218808868 0.25111259097406 no 878 0.265680684277924 1370 6469797 YMR079W SEC14 SGTC_75 0159-0059 199.013 µM 0.62575305167404 0.251172786223129 no 879 0.26573846505113 1418 5377270 SGTC_410 α-linolenic acid 100 µM 0.625654263686544 0.251206544822971 no 880 0.265770869150749 1332 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_193 1273-0060 1.558 µM 0.625067155934229 0.251407225349159 no 881 0.265963491554784 1188 2847393 YHR072W ERG7 SGTC_1969 st069479 40.1 µM 0.624636559446747 0.251554462278351 no 882 0.266104809596837 1318 3895485 SGTC_1866 st057638 64 µM 0.623903027983618 0.251805388794775 no 883 0.266345635807703 1299 688802 SGTC_831 k061-1017 217 µM 0.622665962831749 0.252228863332198 no 884 0.266752027188331 1340 1240153 SGTC_199 4063-0024 41.6 µM 0.622636637298328 0.252238906660465 no 885 0.266761664794262 1327 306215 SGTC_2606 farnesol 9.78 µM 0.622142660055435 0.252408114320243 no 886 0.266924032974216 1343 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_262 fenpropimorph 62.5 µM 0.621680461097389 0.252566490761523 no 887 0.267076000964776 1260 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3311 9131146 2.8755 µM 0.62162431887638 0.252585731940785 no 888 0.267094463134374 1311 4900406 YPR165W RHO1 SGTC_452 diindolylmethane 8 µM 0.620833731241352 0.252856765766061 no 889 0.267354513469982 1307 3071 Inhibits expression of several cancer promoting factors. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.620332592350995 0.253028648342301 no 890 0.267519420691007 1345 5377381 SGTC_1695 st026914 34.495 µM 0.619609769889006 0.253276673053042 no 891 0.267757366500199 1285 3289191 SGTC_2238 6671620 73.2395 µM 0.619501630292486 0.253313790376852 no 892 0.26779297412471 1272 729941 SGTC_1760 st045453 10.4495 µM 0.619405647148326 0.253346737572758 no 893 0.267824580936353 1321 3323419 YIL048W NEO1 SGTC_1400 3771-8998 51.5 µM 0.618373005287294 0.253701344887789 no 894 0.268164744016939 1282 670767 SGTC_1987 st072290 61.9 µM 0.618368842895886 0.253702774772579 no 895 0.26816611559224 1340 54697379 SGTC_495 decylubiquinone 155 µM 0.618251005666877 0.253743256542077 no 896 0.268204946329958 1258 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2184 6075246 200 µM 0.618013175055833 0.253824971134857 no 897 0.26828332693615 1338 2267320 SGTC_1693 xanthone 101.9 µM 0.617184469577034 0.254109808273677 no 898 0.268556529118449 1359 7020 An insecticide. SGTC_2840 9008771 71.43 µM 0.614092444997331 0.255174056409298 no 899 0.269577120193209 1304 2992978 SGTC_2899 9053889 58.44 µM 0.612054442575485 0.255876791548485 no 900 0.270250868923155 1301 6470052 SGTC_2236 dapsone 200 µM 0.611999863171028 0.255895625258364 no 901 0.270268924045891 1322 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3127 9126946 49.47 µM 0.611882884394332 0.255935993550343 no 902 0.270307623204814 1277 27243249 SGTC_2918 7977171 22.06 µM 0.611748460295427 0.25598238616424 no 903 0.270352097081553 1269 2236483 SGTC_403 arphamenine a 50 µM 0.611092771813599 0.256208741075578 no 904 0.270569082395069 1285 5487158 An arginine aminopeptidase inhibitor. SGTC_426 0988-0037 14.6 µM 0.61003646222142 0.256573616628553 no 905 0.270918827094307 1334 5383008 SGTC_1379 2144-0755 36.5 µM 0.609919561726907 0.256614013587989 no 906 0.27095754677352 1353 5392327 SGTC_1571 st070080 73.4 µM 0.608279359942874 0.257181162370525 no 907 0.271501103933935 1416 4315245 SGTC_194 1486-1323 56.904 µM 0.604209299115458 0.25859131746319 no 908 0.272852249609827 1303 5178754 SGTC_1739 st037196 92.5 µM 0.603570042874604 0.258813163990603 no 909 0.273064767349461 1363 612214 SGTC_2981 9013952 38.96 µM 0.603376733583981 0.258880269145921 no 910 0.273129048269191 1235 2996344 SGTC_2253 7938677 135.83 µM 0.598538817712058 0.260562624441085 no 911 0.274740232962463 1443 2301972 SGTC_1827 berberine 7.24 µM 0.598430050804925 0.260600512051007 no 912 0.274776509703141 1248 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1312 1218-2183 165 µM 0.59835391809469 0.260627033628312 no 913 0.274801903450783 1348 6744073 SGTC_2298 7976326 193.81 µM 0.598324198191104 0.260637387225627 no 914 0.274811816714484 1239 2235818 SGTC_1175 0741-0056 27.6 µM 0.597006836443414 0.261096532417092 no 915 0.275251408143274 1421 765927 SGTC_2285 7945142 200 µM 0.594362767554035 0.262019333042277 no 916 0.276134752706054 1343 2970608 SGTC_3096 9117468 49.47 µM 0.593725014840033 0.262242163710337 no 917 0.276348024631355 1261 41316311 SGTC_364 0083-0097 67.7 µM 0.591605161911379 0.262983536900459 no 918 0.277057508233025 1382 5207356 SGTC_2155 5570423 76 µM 0.588010289860655 0.26424321073973 no 919 0.278262693059966 1338 797402 SGTC_941 3237-0776 460 µM 0.587646310856826 0.264370923177687 no 920 0.278384859770534 1410 760008 SGTC_1042 0350-0096 82 µM 0.587529081948255 0.264412062979982 no 921 0.278424212302708 1340 3122515 SGTC_1399 3562-5772 25 µM 0.586904372189688 0.264631350836024 no 922 0.278633966607683 1315 23847490 SGTC_2965 9082772 38.63 µM 0.586125988034642 0.264904711407825 no 923 0.278895426683171 1404 16459634 SGTC_2052 5265182 7.135 µM 0.585147868721056 0.265248420290097 no 924 0.27922414716646 1415 1239884 SGTC_1269 0831-0796 3.05 µM 0.584340161552046 0.265532417318879 no 925 0.279495738434618 1373 927758 SGTC_3195 9113082 49.47 µM 0.582711580988355 0.266105509408078 no 926 0.280043737875844 1340 17018038 SGTC_2794 7785382 27.27 µM 0.58156254484873 0.266510227931997 no 927 0.280430688996129 1351 2205081 SGTC_2688 kanamycin b 96.69 µM 0.579598912501277 0.267202586966115 no 928 0.28109256328678 1411 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1374 2889-5571 141 µM 0.578962648568047 0.267427122458377 no 929 0.281307188177672 1364 2853281 SGTC_2938 9059746 27.26 µM 0.578905589934844 0.267447262915034 no 930 0.281326439090925 1380 6471769 SGTC_2970 9090938 41.86 µM 0.575110550874256 0.268788544340992 no 931 0.282608266359189 1413 17217104 SGTC_110 0850-0284 111.64 µM 0.573554280776981 0.26933955240923 no 932 0.283134728705098 1257 3906265 SGTC_1742 st038235 28.8875 µM 0.573068814668374 0.269511550828753 no 933 0.283299050697777 1394 564103 YBR002C RER2 SGTC_3226 9131256 49.47 µM 0.570449373854021 0.270440555496591 no 934 0.284186474967453 1289 17178073 SGTC_2387 9077560 195.08 µM 0.569783548634832 0.270676950315458 no 935 0.28441225749468 1344 5303272 SGTC_821 1114-0266 29.2 µM 0.569581513670211 0.270748701280208 no 936 0.28448078485917 1374 3123235 SGTC_191 3914-0123 66.505 µM 0.567982331350503 0.271316971839036 no 937 0.285023482690202 1292 3144412 SGTC_975 1335-0046 28.5 µM 0.567490833747092 0.271491745202672 no 938 0.285190376227831 1316 16486740 SGTC_1509 1326-1131 80 µM 0.566969452494353 0.271677206274494 no 939 0.285367467982587 1348 768313 SGTC_76 0433-0009 400.328 µM 0.566845775689393 0.271721208733394 no 940 0.285409483587562 1395 2841569 SGTC_2021 4019055 173 µM 0.566028076893915 0.272012223636754 no 941 0.285687347119331 1395 44827708 YER133W GLC7 SGTC_291 SEC14.278 35.5 µM 0.565566647856587 0.272176512302213 no 942 0.285844202840593 1435 1068044 SGTC_2817 7995342 71.43 µM 0.561639216766055 0.273576840575489 no 943 0.287180927638234 1319 18879975 SGTC_1140 3229-1848 2.98 µM 0.560923581393765 0.273832384350185 no 944 0.287424816790571 1396 2849525 SGTC_2462 5162487 171.77 µM 0.559495214948084 0.274342787445359 no 945 0.287911897992457 1375 2259986 SGTC_679 0422-0091 41.4 µM 0.55918036388295 0.274455357399824 no 946 0.288019316425862 1379 627384 YHR062C RPP1 SGTC_1101 ebselen 5.29 µM 0.559075642624157 0.274492803859382 no 947 0.288055048600975 1456 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1139 k015-0024 46.9 µM 0.556726055302304 0.275333636718779 no 948 0.288857306088999 1390 2766652 SGTC_539 4859-0462 2.54 µM 0.556626482246193 0.275369298314952 no 949 0.288891328138849 1436 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_894 0960-0238 55.9 µM 0.556391243931112 0.275453556777185 no 950 0.288971711685763 1391 6741907 YDL195W SEC31 SGTC_508 roscovitine 141 µM 0.555176458616172 0.275888874480087 no 951 0.289386984722719 1461 160355 A CDKinase inhibitor. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.55496265553876 0.275965525666168 no 952 0.289460102077585 1445 676296 Flavone; oxidizing agent. SGTC_3164 9100705 49.47 µM 0.554532204301537 0.276119879757669 no 953 0.289607336076911 1455 17174235 SGTC_169 k015-0017 16.025 µM 0.554135162774813 0.276262291135807 no 954 0.289743173591044 1480 1840002 SGTC_884 0851-0618 334 µM 0.553918369032615 0.276340066210049 no 955 0.289817356593129 1397 9642473 SGTC_2006 4011487 200 µM 0.550108965698411 0.277708445129648 no 956 0.291122318791507 1502 45595294 SGTC_136 0097-0015 404.482 µM 0.549993487316863 0.277749977841082 no 957 0.291161920277008 1421 4861337 SGTC_1176 0848-0131 83.3 µM 0.549458107023903 0.277942571210875 no 958 0.291345553342045 1467 6769040 SGTC_829 1635-0120 117 µM 0.548867041347258 0.278155272057851 no 959 0.291548348993592 1483 285054 SGTC_2340 7987427 183.45 µM 0.548825280948231 0.27817030295373 no 960 0.291562679547735 1439 2239331 SGTC_720 r052-1644 49.9 µM 0.546392890050852 0.279046480609199 no 961 0.292397948189639 1400 1422863 YOR257W CDC31 SGTC_186 3455-3465 67.277 µM 0.545871010643142 0.279234642823896 no 962 0.292577303344723 1375 755278 SGTC_1188 1403-0014 4.57 µM 0.544759830251323 0.279635481224265 no 963 0.292959354732331 1421 9614867 SGTC_2038 4100038 30.985 µM 0.543533220204925 0.280078282859115 no 964 0.293381362316488 1453 3596803 SGTC_3064 1327-0027 10 µM 0.542844240290432 0.280327150994697 no 965 0.29361852505679 1346 16000455 YPR107C YTH1 SGTC_2766 oltipraz 83.91 µM 0.542348403710868 0.280506319592817 no 966 0.293789258319422 1480 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2162 5663267 200 µM 0.540925019192589 0.281020961698718 no 967 0.294279632641354 1461 6456493 SGTC_931 2812-0076 566 µM 0.540173654303724 0.281292810732798 no 968 0.294538639893492 1431 3450959 SGTC_1361 1608-0041 5.61 µM 0.539861057652711 0.281405947755695 no 969 0.294646427835406 1387 X1361 SGTC_20 0481-0013 4.944 µM 0.538248499210447 0.28198992400673 no 970 0.295202750609155 1405 182045 SGTC_2161 5662504 8.5105 µM 0.537826515318761 0.282142838691113 no 971 0.295348412252947 1400 2859334 SGTC_1885 st057546 99.9 µM 0.537563252708311 0.282238257617553 no 972 0.295439302765502 1504 702008 SGTC_2705 st078069 42.8 µM 0.537520509872022 0.282253751125359 no 973 0.29545406079694 1390 1530061 SGTC_445 e6 berbamine 66 µM 0.537170234533787 0.282380735040849 no 974 0.295575014876347 1438 6610268 A calcium/calmodulin antagonist. SGTC_325 2810-4341 181 µM 0.536904672811096 0.282477026380259 no 975 0.295666731545525 1519 774970 SGTC_481 bay k-8644 50 µM 0.5366649443072 0.282563964283241 no 976 0.295749537464909 1381 2303 A calcium channel antagonist. SGTC_3181 9108277 49.47 µM 0.536543531522245 0.28260799971905 no 977 0.295791479376265 1368 17097298 SGTC_281 1672-3440 14.9 µM 0.536210291610663 0.282728880090508 no 978 0.295906610772681 1448 6833000 SGTC_1793 st048256 72.231 µM 0.535237149277921 0.283082022576362 no 979 0.296242940442862 1375 672022 SGTC_1049 3226-0134 66 µM 0.53187882867246 0.284302342758615 no 980 0.297404960705574 1445 5702385 SGTC_2849 9019321 12.99 µM 0.531406502774563 0.284474174317319 no 981 0.29756855813428 1432 16489627 SGTC_2866 9034245 58.44 µM 0.531295789762433 0.284514458745985 no 982 0.297606911252077 1475 6462273 SGTC_3060 1327-0027 12.5 µM 0.530769996041716 0.28470581309996 no 983 0.29778908710797 1411 16000455 YPR107C YTH1 SGTC_3348 9149464 3.537 µM 0.530173778851018 0.284922871264391 no 984 0.297995724651094 1417 1951442 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.528428669168544 0.285558647177455 no 985 0.298600921739252 1444 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1013 4112-3890 241 µM 0.528220509282676 0.285634528748023 no 986 0.298673148057358 1391 705171 SGTC_326 k292-0812 17.5 µM 0.527819124620197 0.28578087460123 no 987 0.298812441001042 1454 3579357 SGTC_1151 3909-8316 15.3 µM 0.526583517179278 0.286231603889799 no 988 0.299241420353208 1443 800431 SGTC_3341 9147222 25.867 µM 0.525460338754635 0.286641613605835 no 989 0.29963160876073 1433 1939759 SGTC_2237 6667747 47.222 µM 0.525376291679857 0.286672305696371 no 990 0.299660815699773 1461 729940 YDL015C TSC13 SGTC_3215 9129942 49.47 µM 0.524749994453228 0.286901064334383 no 991 0.299878498914869 1442 17682944 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.523000045109114 0.287540701373233 no 992 0.300487110928056 1472 1609 A potent and irreversible inhibitor of serine proteases. SGTC_180 1486-1293 102.781 µM 0.522551991888736 0.287704580995487 no 993 0.300643028284237 1586 4140536 SGTC_1636 st007707 68.9 µM 0.522130306159536 0.287858856766528 no 994 0.300789803407607 1520 403051 SGTC_1466 k213-0079 57.5 µM 0.521882300810734 0.28794960896985 no 995 0.300876141119459 1437 3657981 SGTC_361 000s-0510 1.45 µM 0.52128092856297 0.288169724233935 no 996 0.301085542290099 1448 660 SGTC_970 1315-0089 19.5 µM 0.520345652402072 0.288512213205547 no 997 0.301411341100027 1384 6811083 YLR033W RSC58 SGTC_255 tunicamycin 200.472 nM 0.520297049625269 0.288530016308107 no 998 0.301428275972869 1462 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2928 9011484 9.79 µM 0.520089557658935 0.288606026033112 no 999 0.301500578100126 1456 2994751 SGTC_847 0342-0274 5.54 µM 0.519967849132104 0.288650615433153 no 1000 0.301542991977365 1516 18097 SGTC_570 0987-0065 62.6 µM 0.519128947786804 0.288958045376611 no 1001 0.301835411440695 1389 3104428 SGTC_2594 a-mangostin 100 µM 0.516522217261486 0.28991430875781 no 1002 0.302744862908746 1554 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_185 k048-0037 25.491 µM 0.515485617001495 0.29029499131062 no 1003 0.303106858875161 1467 6827589 SGTC_1870 st057514 26.5 µM 0.515035750904093 0.290460273591262 no 1004 0.303264018915528 1459 5393161 SGTC_2441 5730946 39.09 µM 0.514914650416511 0.290504773831506 no 1005 0.303306331409767 1522 1774275 SGTC_1410 3909-8106 77.9 µM 0.514774677335867 0.29055621307192 no 1006 0.303355241272853 1506 1039210 SGTC_2160 5660466 132.927 µM 0.514748031008798 0.290566005915003 no 1007 0.303364552521126 1468 2859134 SGTC_775 4577-0580 57.3 µM 0.514349836757606 0.290712365447162 no 1008 0.303503712070737 1515 2006902 SGTC_3054 9094397 49.47 µM 0.511358396630734 0.291812994421227 no 1009 0.304550060523211 1408 2598354 SGTC_1423 4048-0112 5.59 µM 0.510510838101831 0.292125185918325 no 1010 0.304846811774638 1536 X1423 SGTC_1751 st044839 27.194 µM 0.510398680809871 0.292166509814461 no 1011 0.304886090448204 1493 5291326 SGTC_1012 4112-3522 18 µM 0.509525720452122 0.292488241431309 no 1012 0.305191887259447 1521 3112398 SGTC_1935 st074532 41.6 µM 0.508802590415309 0.292754877363714 no 1013 0.305445301748626 1597 2829742 SGTC_1434 4073-0095 163 µM 0.506970508689172 0.293430915945356 no 1014 0.306087755700511 1470 24133745 SGTC_468 gf-109203x 121 µM 0.505825206956172 0.29385389957791 no 1015 0.306489680672556 1461 2396 A protein kinase C inhibitor. SGTC_807 1315-0151 48 µM 0.504159697275751 0.294469509560693 no 1016 0.307074579660582 1583 4011080 SGTC_466 geldanamycin 89.2 µM 0.503488229525539 0.294717867461929 no 1017 0.307310526883438 1423 5288382 HSP90 inhibitor. SGTC_758 0868-0029 16 µM 0.502701759652653 0.295008884330452 no 1018 0.307586986173542 1563 762687 SGTC_1735 st034310 56.75 µM 0.501193826394638 0.295567233687333 no 1019 0.308117359363861 1589 871153 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.498580797784519 0.296535920430376 no 1020 0.309037367768615 1446 5355888 SGTC_2020 4017018 200 µM 0.496328851441063 0.297371913983537 no 1021 0.309831206887225 1481 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.496070481158226 0.29746789799455 no 1022 0.309922342456583 1447 390807 SGTC_1834 st055981 52.8 µM 0.495182658052486 0.297797830172377 no 1023 0.310235595438078 1569 471719 YDL150W RPC53 SGTC_1303 1160-0052 261 µM 0.495128595390103 0.297817926289861 no 1024 0.310254674961879 1490 3562476 SGTC_1670 st016595 4.04 µM 0.493780192075486 0.298319353345336 no 1025 0.310730711816715 1486 597879 SGTC_492 tmb-8 126 µM 0.493640959587041 0.298371151234758 no 1026 0.310779884168724 1441 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2605 digitonin 300 nM 0.493158425774239 0.298550697278526 no 1027 0.31095032544688 1531 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.493097687664698 0.298573300808313 no 1028 0.31097178232306 1734 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_41 0478-0632 82.643 µM 0.49274504149074 0.298704552542407 no 1029 0.311096373892272 1532 3750424 SGTC_478 N-arachidonylglycine 10 µM 0.492709180207997 0.298717901258484 no 1030 0.311109045066936 1481 5283389 SGTC_132 0417-1715 25.805 µM 0.491727548994008 0.299083401038237 no 1031 0.311455980145557 1615 6769098 SGTC_1208 2323-2347 50.3 µM 0.491329390259751 0.299231708996064 no 1032 0.311596747998307 1545 5412760 SGTC_1068 loratadine 26.9 µM 0.490576913550212 0.29951208599176 no 1033 0.3118628591262 1471 3957 A H1 histamine antagonist. SGTC_2310 7668677 200 µM 0.489914884100904 0.299758860261131 no 1034 0.31209706510339 1539 2197143 SGTC_901 1112-0062 60.1 µM 0.488636129680311 0.300235781865403 no 1035 0.312549664739127 1503 1908457 SGTC_33 0986-0033 35.816 µM 0.488573732141359 0.300259062297761 no 1036 0.31257175683545 1477 2848082 SGTC_3062 9077494 49.47 µM 0.487686720643297 0.300590093226524 no 1037 0.312885879583839 1521 16459633 SGTC_2916 7875993 68.79 µM 0.486833852807155 0.300908537099976 no 1038 0.313188038999829 1619 1299250 SGTC_3225 9130819 49.47 µM 0.485227770859368 0.301508628740196 no 1039 0.313757392398658 1540 4547121 SGTC_1145 3546-0597 10.2 µM 0.483003159730016 0.302340714019493 no 1040 0.314546746346265 1496 875334 SGTC_1 0258-0098 57.368 µM 0.48267905907856 0.302462025343286 no 1041 0.314661817172048 1475 6790032 YDR047W HEM12 SGTC_205 1486-1330 71.903 µM 0.482383189207585 0.302572788898923 no 1042 0.314766880474993 1522 4118834 SGTC_1689 st020265 53.493 µM 0.482209201830375 0.302637932307 no 1043 0.314828670343286 1587 5758320 YPR016C TIF6 SGTC_3151 9099821 49.47 µM 0.481625589021509 0.302856491323504 no 1044 0.315035972418967 1468 17174189 SGTC_490 phenamil 164 µM 0.481484524204577 0.302909329738409 no 1045 0.315086088067695 1572 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2764 methyldopa 94.69 µM 0.480322107548999 0.303344891227012 no 1046 0.315499185659439 1598 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1930 st074634 34.3 µM 0.479687807486619 0.303582683602341 no 1047 0.315724699424901 1451 684253 YOR116C RPO31 SGTC_1642 st009582 77.7 µM 0.479192810465045 0.303768310542675 no 1048 0.315900734224331 1576 6739311 SGTC_1949 st076024 69.1 µM 0.478544584372941 0.304011475886317 no 1049 0.316131324717777 1458 2921930 SGTC_3338 9144300 39.5675 µM 0.477612855876797 0.304361141775413 no 1050 0.316462889518119 1554 4901274 SGTC_2102 5377816 72.7585 µM 0.476605118100601 0.304739534405679 no 1051 0.316821669096996 1610 1379702 SGTC_1959 st077091 55.8 µM 0.476029329160627 0.304955829622439 no 1052 0.317026741597424 1496 821356 YKL052C ASK1 SGTC_2859 9028643 45.46 µM 0.4758252851111 0.30503249516764 no 1053 0.317099427246382 1519 17151580 SGTC_2430 5571206 200 µM 0.475446632384264 0.305174789169245 no 1054 0.317234331619012 1591 1731771 SGTC_3125 9127534 49.47 µM 0.474200038869921 0.305643454862576 no 1055 0.317678632831223 1474 1639235 SGTC_1313 1220-0047 237 µM 0.473683036113487 0.305837919231451 no 1056 0.317862976056317 1572 3528706 SGTC_700 3453-2283 142 µM 0.47345517346877 0.305923644412928 no 1057 0.31794423741646 1592 565664 SGTC_2736 butenafine 14.65 µM 0.472600268828229 0.306245366501968 no 1058 0.318249195324865 1569 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_877 0771-0151 33.1 µM 0.472434994688765 0.306307580559774 no 1059 0.318308165426072 1567 6166523 SGTC_1573 oleylamine 1.06 µM 0.472140595107669 0.306418415073813 no 1060 0.318413219115498 1485 5356789 An amine of the fatty acid oleic acid. SGTC_2765 myclobutanil 7.74 µM 0.471172212444823 0.306783113269205 no 1061 0.318758880236768 1521 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1116 jasmonic acid  1.58368 µM 0.469499361418355 0.307413568726199 no 1062 0.319356370597512 1573 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_312 4092-0653 6.84 µM 0.468974249179374 0.307611587832933 no 1063 0.319544021230046 1586 1148278 SGTC_704 1310-0270 142 µM 0.468404191200134 0.307826619390371 no 1064 0.319747785693787 1478 5718033 SGTC_1274 0865-0114 173 µM 0.467810238588311 0.308050734469656 no 1065 0.319960149062563 1542 870624 SGTC_1449 4112-4002 201 µM 0.466058188509429 0.308712249270043 no 1066 0.320586925201575 1461 2059539 SGTC_1297 1068-0111 14.1 µM 0.463770786290586 0.309576829701078 no 1067 0.3214059878756 1479 767057 SGTC_990 3985-0011 41.3 µM 0.463384367039813 0.309722990726255 no 1068 0.321544441066831 1532 5399565 YGL099W LSG1 SGTC_3086 9117350 49.47 µM 0.462287042860922 0.310138211747405 no 1069 0.321937745091764 1476 2679265 SGTC_1414 3917-0015 5.4 µM 0.460755162368911 0.310718271329445 no 1070 0.322487136901115 1542 6618702 SGTC_1700 st030840 7.9285 µM 0.460557253504096 0.31079324557662 no 1071 0.322558143018989 1636 5499307 SGTC_3294 9122953 26.2835 µM 0.460556423723446 0.310793559940776 no 1072 0.322558440742892 1492 16459826 SGTC_471 1-acyl-paf 4 µM 0.460163259898293 0.31094252642126 no 1073 0.322699520058272 1463 16759367 SGTC_2250 alverine citrate 130 µM 0.459995248308673 0.311006194056767 no 1074 0.322759815588095 1509 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1876 myriocin 605 nM 0.458842668355887 0.3114431142208 no 1075 0.323173575829615 1633 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2362 9071156 126 µM 0.457087041748965 0.312109147860141 no 1076 0.323804241937061 1597 653133 SGTC_1439 4092-1168 46 µM 0.455434127669956 0.312736777223723 no 1077 0.324398473829044 1562 2886240 SGTC_2636 apigenin dimethyl ether 100 µM 0.454446259979864 0.313112140804888 no 1078 0.324753831539216 1557 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2335 9018011 154.17 µM 0.451863092122214 0.314094591256776 no 1079 0.325683807225634 1659 6458208 SGTC_571 k831-0106 44.2 µM 0.451719220037981 0.314149348641688 no 1080 0.325735635116735 1644 4783639 SGTC_2955 9076254 12.21 µM 0.451359996927083 0.314286085990997 no 1081 0.32586505488354 1627 16459619 SGTC_1398 3558-0053 112 µM 0.450733678794347 0.314524553326046 no 1082 0.326090752984564 1519 4532369 SGTC_1675 st018485 24.5 µM 0.450564297587018 0.314589057630584 no 1083 0.326151801632285 1556 3323024 SGTC_1469 k284-2957 126 µM 0.449218022936617 0.315101951464234 no 1084 0.326637193683416 1589 23884841 SGTC_2144 5628481 200 µM 0.448613756428954 0.315332276517949 no 1085 0.326855154227313 1562 2818399 SGTC_166 k072-0058 166.424 µM 0.448358622886791 0.315429545973189 no 1086 0.326947199323814 1587 5846229 SGTC_2319 6033012 152.6 µM 0.448029634462272 0.315554991424249 no 1087 0.327065904753205 1478 847246 SGTC_1838 st055369 84.5 µM 0.447871055204551 0.315615466332535 no 1088 0.327123129487765 1523 676036 SGTC_2862 9027634 71.43 µM 0.44652098947275 0.316130519761702 no 1089 0.327610477184811 1479 5012562 SGTC_874 0599-0792 117 µM 0.446215605282079 0.316247074137484 no 1090 0.327720755770429 1696 765305 SGTC_967 1306-0166 352 µM 0.445797172743386 0.316406804729559 no 1091 0.327871882127774 1666 4437607 SGTC_2549 cedrol 20.94 µM 0.443850114765126 0.317150516230285 no 1092 0.328575476550632 1614 6708665 A sedative which affects the nervous system. SGTC_3117 9124945 49.47 µM 0.440631433449279 0.318381565504479 no 1093 0.32973992135989 1462 17592065 SGTC_1554 st069299 38.7 µM 0.440522235843354 0.318423365615785 no 1094 0.329779455580132 1582 24207999 SGTC_127 0180-0333 59.125 µM 0.440507662873757 0.318428944225668 no 1095 0.329784731764462 1557 771601 SGTC_1512 0259-0544 12.2 µM 0.440473695141135 0.318441947413289 no 1096 0.329797030008378 1628 18476 SGTC_2398 5228213 48.84 µM 0.440286876411951 0.318513467487807 no 1097 0.329864672262694 1728 80771 YMR134W ERG29 SGTC_1588 farnesol 29.9 µM 0.440135942188469 0.318571254786374 no 1098 0.329919325724597 1539 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2539 epi(13)torulosol 80 µM 0.438280178715031 0.319282120388158 no 1099 0.33059159633744 1527 6708597 SGTC_1489 4065-0444 182 µM 0.437578500792663 0.319551077309651 no 1100 0.33084592945535 1671 2877968 SGTC_133 0724-0033 378.92 µM 0.437350965546921 0.319638313185812 no 1101 0.330928419607752 1502 280309 SGTC_634 1611-4317 11.2 µM 0.436832415128531 0.319837160108371 no 1102 0.331116444459968 1621 2843522 SGTC_1794 st048918 76.9 µM 0.435870359002019 0.320206213921616 no 1103 0.33146539596609 1641 672303 SGTC_1020 4335-0961 93.3 µM 0.435686570596512 0.320276737142989 no 1104 0.331532075305855 1502 669075 SGTC_1334 1486-0610 236 µM 0.433962794797331 0.3209384994788 no 1105 0.332157729310423 1603 3742339 SGTC_2316 5844804 197.44 µM 0.43290056368202 0.321346576589486 no 1106 0.332543505244462 1694 776813 SGTC_1998 st075797 76.8 µM 0.432541544048188 0.321484549898644 no 1107 0.332673932388097 1661 24208315 SGTC_2820 7989630 71.43 µM 0.430281728240063 0.322353574951005 no 1108 0.333495358410714 1649 2984098 SGTC_334 1502-1024 68.5 µM 0.430147835618539 0.322405094660619 no 1109 0.333544052479591 1592 3296216 SGTC_1262 0737-0114 49.6 µM 0.4297147575735 0.322571759425838 no 1110 0.33370157350671 1633 765919 SGTC_3097 9117246 49.47 µM 0.42887554127843 0.322894822982732 no 1111 0.334006900329939 1565 16423892 SGTC_600 1495-0418 41.6 µM 0.428195565548243 0.323156683568433 no 1112 0.334254372268847 1582 5377768 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.4281840923345 0.32316110268799 no 1113 0.334258548475272 1561 6708630 An antioxidant. SGTC_2016 5121758 140 µM 0.427733404159923 0.32333471327759 no 1114 0.334422613494216 1539 2795203 SGTC_2342 7990637 118.86 µM 0.42771372288588 0.323342295621803 no 1115 0.334429778833197 1623 2033102 YER133W GLC7 SGTC_988 1497-1057 103 µM 0.427335251428024 0.323488118585033 no 1116 0.334567580234801 1671 3533044 SGTC_1218 1348-1416 30.7 µM 0.426464160183628 0.323823848221862 no 1117 0.334884829087789 1582 6787668 SGTC_1808 st050063 61.5 µM 0.426209563380383 0.323922000157514 no 1118 0.334977574759553 1650 4011993 SGTC_2118 5526350 200 µM 0.426031768868684 0.323990550602553 no 1119 0.335042348514783 1639 743594 SGTC_945 3381-0768 11.3 µM 0.424592655872745 0.324545634483194 no 1120 0.335566823841318 1614 1126236 YIL048W NEO1 SGTC_1046 2001-0062 216 µM 0.421145788435436 0.32587671823132 no 1121 0.336824313878375 1570 739778 SGTC_104 0074-0074 590.992 µM 0.420345851826899 0.326185949720649 no 1122 0.337116409262671 1609 3943124 SGTC_554 4483-2211 187 µM 0.420344120005997 0.3261866193204 no 1123 0.337117041740515 1604 747107 SGTC_583 1488-1091 88.9 µM 0.419134993574216 0.32665425857215 no 1124 0.337558738768278 1676 4303273 SGTC_1075 aripiprazole 15.2 µM 0.417254539342427 0.327382080423353 no 1125 0.338246118276334 1588 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1279 0874-0590 65.2 µM 0.415523813956289 0.328052530815326 no 1126 0.338879242904921 1627 3523074 SGTC_2004 4023728 41.89 µM 0.414883200917643 0.328300832932784 no 1127 0.339113704093513 1717 360084 YDR527W RBA50 SGTC_3281 9140613 49.47 µM 0.414839372725093 0.328317823548784 no 1128 0.3391297472729 1504 16013766 SGTC_3201 9113999 49.47 µM 0.414458102013979 0.328465643486887 no 1129 0.339269322584649 1689 16649224 SGTC_13 0199-0087 65 µM 0.412894191565 0.329072257600791 no 1130 0.339842068429685 1645 4589825 SGTC_2061 5245884 80.95 µM 0.410947283876852 0.329828059057858 no 1131 0.340555594932102 1601 573863 SGTC_965 1291-5240 308 µM 0.41065544941269 0.329941410978556 no 1132 0.340662599264185 1698 2834598 SGTC_2906 7926292 26.41 µM 0.410462777614496 0.330016255518622 no 1133 0.340733251537555 1584 2966319 SGTC_578 3460-0051 92 µM 0.409866156066776 0.330248059959195 no 1134 0.340952066619509 1703 2876744 SGTC_1946 st076057 65.1 µM 0.409625214225207 0.33034169119502 no 1135 0.341040448880732 1553 953009 SGTC_2459 5811157 9.22 µM 0.408419657124805 0.330810336323119 no 1136 0.341482802144875 1583 2870684 YBR192W RIM2 SGTC_1645 Cervolide 78 µM 0.408411595880727 0.330813470923861 no 1137 0.341485760778952 1601 23173 A fragrance. SGTC_621 3584-0052 32.1 µM 0.407772242148476 0.331062120277191 no 1138 0.341720447099948 1713 2273927 SGTC_2035 5154463 94.595 µM 0.407312655868539 0.33124090279778 no 1139 0.341889184342792 1686 2769623 SGTC_2654 protoveratrine a 100 µM 0.406593353373787 0.33152079409888 no 1140 0.342153339873196 1625 5702278 A heart drug and vasodilator. SGTC_3038 9091290 49.47 µM 0.406454820501857 0.331574710112436 no 1141 0.342204223346912 1669 25236843 SGTC_1252 0493-0875 34.8 µM 0.405984089045694 0.33175794153533 no 1142 0.342377145603743 1582 3960963 SGTC_112 phenothiazine 287.218 µM 0.405946115055209 0.33177272460214 no 1143 0.34239109671408 1764 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1915 st067105 30.6 µM 0.405504256670396 0.331944756907237 no 1144 0.342553445079649 1550 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2844 9010103 25.97 µM 0.405183348067545 0.332069721069192 no 1145 0.342671372106944 1607 2480525 SGTC_2034 5197015 53.07 µM 0.404535084340482 0.332322216683047 no 1146 0.342909641886544 1711 780676 SGTC_2218 6965428 192.983 µM 0.404383930657657 0.332381101265984 no 1147 0.34296520751438 1676 675684 SGTC_2490 carminic acid 95.39 µM 0.402736568884193 0.333023128100186 no 1148 0.34357101441934 1613 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3277 9138724 49.47 µM 0.40242110141215 0.333146131270883 no 1149 0.343687071504213 1633 15943418 SGTC_969 1313-0238 134 µM 0.399443912441216 0.334307842446468 no 1150 0.344783071600386 1631 5212874 SGTC_841 0251-0215 91.2 µM 0.399002944451469 0.334480045292179 no 1151 0.344945517346228 1670 3888614 SGTC_596 1155-0152 116 µM 0.396629503790789 0.335407497423304 no 1152 0.345820346252937 1618 280313 SGTC_2699 st077704 54.6 µM 0.395092160208089 0.336008770137844 no 1153 0.346387437230023 1628 645852 SGTC_1811 st050069 61.5 µM 0.394333014032351 0.336305835886075 no 1154 0.34666759608516 1681 3877702 SGTC_2923 7992654 58.14 µM 0.393881735879085 0.336482476534269 no 1155 0.346834177646161 1632 2985126 SGTC_1061 3448-9325 110 µM 0.392003057717187 0.337218221892979 no 1156 0.34752797726281 1653 723482 SGTC_1084 voriconazole 435 nM 0.39181197677113 0.337293089735941 no 1157 0.347598572512267 1740 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_796 1234-0020 70.7 µM 0.391636546841439 0.337361830993272 no 1158 0.347663390115365 1584 46495034 SGTC_808 0711-0032 135 µM 0.391622793280227 0.337367220480445 no 1159 0.347668471950053 1778 4252555 SGTC_3089 9117425 49.47 µM 0.391019495782805 0.337603662189337 no 1160 0.347891412640098 1585 9401657 SGTC_3041 9091929 49.47 µM 0.389834336921613 0.338068331085821 no 1161 0.348329525668741 1687 25236887 SGTC_203 k066-0004 30.888 µM 0.387533465032503 0.338971145252887 no 1162 0.349180657563391 1721 6795412 SGTC_1650 st011916 45.8 µM 0.386228711376791 0.339483515027326 no 1163 0.349663645873479 1745 242528 SGTC_959 1222-0044 107 µM 0.385978957276597 0.339581626003177 no 1164 0.34975612659564 1779 6083612 SGTC_2282 7944268 200 µM 0.385647765983046 0.339711744741801 no 1165 0.349878776209511 1719 2970414 SGTC_284 0988-0104 32.6 µM 0.384841299118819 0.340028670053282 no 1166 0.350177499465523 1712 4666532 SGTC_926 2268-1401 59.4 µM 0.384739565353005 0.340068657420184 no 1167 0.350215189242498 1622 2931578 SGTC_1060 3448-7350 82 µM 0.384473321078295 0.340173315628713 no 1168 0.350313832967284 1758 570178 SGTC_150 3970-0969 77.2 µM 0.383525424558068 0.34054602507106 no 1169 0.350665111347845 1688 6615640 SGTC_2966 9084041 48.03 µM 0.382948587281812 0.340772911639805 no 1170 0.350878942429112 1492 17741380 SGTC_615 k087-0205 167 µM 0.382685391429342 0.340876453228598 no 1171 0.350976523690587 1576 9642773 SGTC_2134 5324836 1.464 µM 0.381725981587421 0.341253987745902 no 1172 0.351332313163632 1686 699272 SGTC_3336 9143619 71.43 µM 0.37972758152984 0.342040882220454 no 1173 0.352073821980137 1714 45595730 SGTC_1023 4482-3888 16 µM 0.379610510468912 0.342087001703875 no 1174 0.352117278821059 1752 3303168 SGTC_3335 9143315 29.6265 µM 0.377555362175144 0.342896998915569 no 1175 0.352880465055197 1631 4899691 SGTC_1122 capsaicin 818.572 nM 0.376172813635579 0.343442310700933 no 1176 0.353394212591797 1736 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2640 pentamidine 10.38 µM 0.373391502635531 0.344540316232691 no 1177 0.354428541435322 1813 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.37331460171692 0.344570693834918 no 1178 0.354457155061317 1661 6708784 An antioxidant flavonoid SGTC_2412 st077135 33.4 µM 0.372803533261629 0.344772602893215 no 1179 0.354647336483111 1747 13258915 SGTC_250 brefeldin a 552.239 µM 0.370547886997812 0.345664274160164 no 1180 0.355487151516887 1647 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3240 9133527 49.47 µM 0.370248604589636 0.345782646888998 no 1181 0.355598632237863 1656 17617455 SGTC_1282 0886-0010 32.4 µM 0.369541919537069 0.346062216075989 no 1182 0.355861916763209 1793 2836211 YNL267W PIK1 SGTC_109 0132-0036 33.701 µM 0.369410735545789 0.34611412255331 no 1183 0.355910798602324 1688 67274 A color developer. SGTC_412 gemfibrozil 100 µM 0.3677111931804 0.346786853295893 no 1184 0.356544296744765 1695 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1126 isoteolin 1.0172 µM 0.367522797679509 0.346861455782253 no 1185 0.356614544883928 1600 133323 SGTC_2043 5101342 149 µM 0.364749381309294 0.347960382973062 no 1186 0.357649246693125 1697 678451 SGTC_2653 dihydrofissinolide 100 µM 0.364703731535798 0.347978481770649 no 1187 0.357666286418104 1712 6857746 SGTC_3076 9116187 49.47 µM 0.362493803467879 0.348855067013301 no 1188 0.358491526625034 1814 27241210 SGTC_3157 9099274 49.47 µM 0.362347037469037 0.34891331153409 no 1189 0.358546356031221 1813 17217662 SGTC_3199 9111318 49.47 µM 0.362201471267999 0.348971083428266 no 1190 0.358600740092592 1754 8548020 SGTC_713 1488-1073 324 µM 0.361945655521651 0.349072619326083 no 1191 0.358696320731368 1759 3312542 SGTC_3069 9117009 49.47 µM 0.361267098609309 0.349341997865627 no 1192 0.358949893343285 1710 41904981 SGTC_1723 st034307 2.5525 µM 0.360828799530631 0.349516037433518 no 1193 0.359113716110288 1652 867466 SGTC_1200 1643-0193 18.4 µM 0.360368650187191 0.349698787336249 no 1194 0.359285733716863 1748 5403974 SGTC_2086 5274770 176.623 µM 0.359995355347444 0.34984706826617 no 1195 0.35942530346831 1672 689278 SGTC_3232 9132874 49.47 µM 0.359734042691603 0.349950881036861 no 1196 0.359523015799801 1626 3784940 SGTC_268 camptothecin 39.6153 µM 0.357614538516681 0.350793319167339 no 1197 0.36031589838046 1689 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_224 benfluorex 43.875 µM 0.356658655279133 0.351173493996745 no 1198 0.360673680404045 1800 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2908 7930301 100 µM 0.356480765979375 0.351244260759975 no 1199 0.360740276897926 1618 2223178 SGTC_300 r073-0011 5.04 µM 0.354284605007315 0.352118347455573 no 1200 0.361562801971675 1735 2735780 SGTC_865 0488-0499 301 µM 0.352960292003695 0.352645811079322 no 1201 0.362059104710438 1756 9634651 SGTC_2522 biochanin a 4.94 µM 0.35295572471936 0.352647630684324 no 1202 0.362060816758892 1754 5280373 A possible chelator. SGTC_653 0203-0016 55.2 µM 0.35257317692667 0.352800049597978 no 1203 0.36220422475339 1737 295302 SGTC_2440 5628896 157.78 µM 0.350667270817858 0.353559773433865 no 1204 0.362918991145783 1705 5522048 SGTC_380 3970-0968 6 µM 0.350165977243273 0.353759693934778 no 1205 0.363107069275311 1686 2891601 SGTC_1032 k061-1018 98.7 µM 0.350041004476894 0.353809540510159 no 1206 0.36315396240066 1850 4005393 SGTC_845 0330-0138 4.51 µM 0.349093842561527 0.354187406462524 no 1207 0.363509429535733 1794 9039800 SGTC_1280 0880-0253 10.1 µM 0.34875566063271 0.354322357422588 no 1208 0.363636376732066 1699 6836607 SGTC_2775 cyproheptadine 69.59 µM 0.347854469673274 0.354682065530025 no 1209 0.363974740111362 1787 2913 A selective serotonin reuptake inhibitor. SGTC_2967 9089538 49.85 µM 0.346068359627987 0.355395369626822 no 1210 0.364645670650564 1894 728216 SGTC_2036 5160441 105 µM 0.345925358145776 0.355452500901378 no 1211 0.364699405381346 1753 134534 YIL048W NEO1 SGTC_2477 5967686 25.23 µM 0.345539032014366 0.355606860324535 no 1212 0.3648445859108 1655 776118 SGTC_1848 st056003 16.4 µM 0.345374464326345 0.355672621739059 no 1213 0.364906435981769 1819 146492 SGTC_2679 rapamycin 1 nM 0.343177102488299 0.356551100681853 no 1214 0.365732614717491 1743 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1596 piperlongumine 63 µM 0.343033842655969 0.356608400740666 no 1215 0.36578650018242 1829 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1190 1486-1332 13 µM 0.342616925260696 0.356775174834432 no 1216 0.365943333716094 1658 4150046 SGTC_2749 bexarotene 57.39 µM 0.342180363438285 0.356949836381815 no 1217 0.366107580986929 1648 82146 An retinoic acid receptor inhibitor. SGTC_1311 1190-0148 100 µM 0.341698398188718 0.357142697957912 no 1218 0.366288938846367 1822 1961333 SGTC_450 aminopyrene 156 nM 0.337264151299906 0.358918798419204 no 1219 0.367958890647587 1798 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1921 5740136 50 µM 0.336913608234511 0.35905933628003 no 1220 0.368091013286405 1876 1774243 SGTC_435 c-PAF 6.7 µM 0.336528811208855 0.359213629019839 no 1221 0.36823606449807 1807 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1118 chelidonine 707.474 nM 0.33442067488278 0.360059339082783 no 1222 0.36903107015418 1867 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.33433053835513 0.360095513992078 no 1223 0.369065074333496 1682 229346 A bile salt which induces apoptosis. SGTC_449 xestospongin c 11.1929 µM 0.332787242398038 0.360715086217075 no 1224 0.369647444489342 1779 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3018 9082602 49.47 µM 0.332466118431089 0.360844050802234 no 1225 0.369768659806782 1741 17332089 SGTC_249 wiskostatin 11.211 µM 0.332111599910126 0.36098644514324 no 1226 0.369902495664821 1820 2775510 A n-wasp and actin depolymerizer. SGTC_2842 9000675 19.48 µM 0.331302405113131 0.361311534903299 no 1227 0.370208037390295 1630 2989072 SGTC_3014 9081533 49.47 µM 0.331244939078972 0.36133462539292 no 1228 0.370229738955924 1848 21367265 SGTC_2378 9074213 121.43 µM 0.330494757844721 0.361636102840695 no 1229 0.370513076476897 1702 657714 SGTC_3101 9120531 49.47 µM 0.32788348054493 0.362686173117339 no 1230 0.371499882257799 1836 24824904 SGTC_1752 st044819 83.042 µM 0.326873442320023 0.363092616411467 no 1231 0.371881804317618 1684 441209 YML126C ERG13 SGTC_2837 9008476 45.46 µM 0.326499896845936 0.363242971650174 no 1232 0.372023083665344 1799 2992805 SGTC_2428 5615643 7.78 µM 0.325883391673638 0.363491166324884 no 1233 0.372256290945057 1783 2253075 SGTC_1625 st003711 30.1 µM 0.324327630786084 0.364117744232064 no 1234 0.372845001474373 1821 24207034 YER133W GLC7 SGTC_1181 1222-0449 220 µM 0.323990133295062 0.364253718333251 no 1235 0.372972752090045 1814 658318 SGTC_2744 captopril 92.04 µM 0.322960433767416 0.364668678706412 no 1236 0.373362603480209 1860 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2262 9014885 67.46 µM 0.320320727417725 0.365733181941672 no 1237 0.37436260603496 1862 6457424 SGTC_2622 2-methoxyxanthone 59.94 µM 0.3199800354632 0.365870646910585 no 1238 0.374491732469739 1886 71034 A hepatoprotective. SGTC_1168 k815-0004 80.5 µM 0.319967586104384 0.365875670398392 no 1239 0.374496451196305 1735 642433 SGTC_1498 4478-3555 97.6 µM 0.31988177622881 0.365910296490934 no 1240 0.374528976542409 1868 3437919 SGTC_2993 9054257 71.4286 µM 0.319525185604831 0.366054200017836 no 1241 0.374664148092946 1716 6470217 YGL055W OLE1 SGTC_1845 st056753 3.01 µM 0.316634785571647 0.367221325924579 no 1242 0.375760368892443 1683 5375839 SGTC_60 0986-0278 202 µM 0.316360966580327 0.367331956203979 no 1243 0.375864270387113 1583 3110598 SGTC_2373 9071805 200 µM 0.31558463202218 0.367645676216921 no 1244 0.37615890193873 1918 10149009 SGTC_3083 9117465 49.47 µM 0.315543309484523 0.367662377303593 no 1245 0.376174586536765 1694 16420915 SGTC_3067 9117431 49.47 µM 0.315248946306636 0.367781355574754 no 1246 0.376286322476732 1735 17150885 SGTC_2192 5915882 198.485 µM 0.312193943708135 0.369016900365527 no 1247 0.377446567241371 1775 2876149 SGTC_658 3253-0951 102 µM 0.31112536176385 0.36944939094321 no 1248 0.377852660696046 1782 1184878 SGTC_2067 5224629 34.075 µM 0.31043874790472 0.369727373603738 no 1249 0.378113666011339 1720 2835000 SGTC_340 k038-0059 454 µM 0.310282667866824 0.369790573711671 no 1250 0.378173005115646 1791 23733424 SGTC_1307 1187-1599 12.2 µM 0.309166359968267 0.370242692831988 no 1251 0.378597491012502 1746 1538471 SGTC_119 0121-0043 24.815 µM 0.308773132184402 0.370401997909443 no 1252 0.378747054258818 1814 1092378 SGTC_1591 genipin 88.4 µM 0.307338945840697 0.370983206002381 no 1253 0.379292697352347 1830 442424 A DNA cross-linking agent. SGTC_2616 abietic acid 100 µM 0.307232207640229 0.371026473750034 no 1254 0.379333316044775 1949 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2937 9044753 11.33 µM 0.305929641752945 0.371554617347368 no 1255 0.379829108215681 1728 6465530 YGL099W LSG1 SGTC_1236 0330-0013 258 µM 0.303096391956333 0.372704232282407 no 1256 0.380908201854491 1772 4617066 SGTC_2264 7948757 110.76 µM 0.303073585985902 0.372713490614317 no 1257 0.38091689168621 1717 2971411 SGTC_405 ebelactone b 50 µM 0.302222952042088 0.373058867201688 no 1258 0.381241054317989 1771 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_473 2-arachidonoylglycerol 10 µM 0.301999364589618 0.373149665702496 no 1259 0.381326273667301 1731 5282280 An endocannabinoid. SGTC_1702 st027038 51 µM 0.301601130865889 0.373311405216894 no 1260 0.381478072905197 1803 5521182 SGTC_948 3448-0295 75.3 µM 0.301344457460114 0.37341566294761 no 1261 0.381575921665421 1740 678569 SGTC_1780 st038448 24.544 µM 0.299189992281934 0.374291146123801 no 1262 0.382397542389396 1862 728868 YDL195W SEC31 SGTC_3061 glucosamine 200 µM 0.29886624673234 0.374422758737111 no 1263 0.382521050943934 1911 91431 and experimental redox chemotherapeutic SGTC_3200 9114385 49.47 µM 0.298307281998056 0.374650029685892 no 1264 0.382734323469582 1725 17018030 YLR208W SEC13 SGTC_514 4466-0038 2.65 nM 0.298061465773262 0.37474999054618 no 1265 0.382828125706845 1808 5722064 SGTC_1113 artemisinin 1.17947 µM 0.297944096678561 0.374797721510701 no 1266 0.382872915588695 1930 2240 An anti-malaria and mitochondrial poison. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.297491738107178 0.374981701936608 no 1267 0.383045557339826 1880 94937 An inhibitor of serotonin biosynthesis. SGTC_1259 0671-0132 43 µM 0.297391521850749 0.37502246511183 no 1268 0.383083807820242 1765 X1259 SGTC_2711 st079103 59.1 µM 0.296965889667513 0.375195607457169 no 1269 0.383246275554235 1883 54693780 SGTC_2729 fluphenazine 10.66 µM 0.296483719632298 0.375391779140325 no 1270 0.383430349116957 1740 3372 An atypical antipsychotic. SGTC_2569 tetrandrine 100 µM 0.296405478919196 0.37542361454525 no 1271 0.383460220827783 1708 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1804 st050076 49.1 µM 0.295971741184095 0.375600113702649 no 1272 0.383625831165813 1843 3895976 SGTC_2876 9059903 25.97 µM 0.294390504206905 0.376243780358214 no 1273 0.384229761071352 1801 6916095 SGTC_1251 0490-5699 265 µM 0.292746097807407 0.376913526368215 no 1274 0.384858115847335 1923 3883818 SGTC_1265 0819-1001 68.8 µM 0.291767788481544 0.377312155367451 no 1275 0.385232087602666 1787 3106768 SGTC_2583 asiatic acid 100 µM 0.288874974411332 0.378491645836579 no 1276 0.386338527598585 1823 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_106 0092-0003 11.579 µM 0.288314664656039 0.378720232899718 no 1277 0.38655294138622 1909 1072148 SGTC_882 0843-0131 351 µM 0.287256007181611 0.379152244423911 no 1278 0.386958152449394 1931 5425421 SGTC_2193 5925765 200 µM 0.286994052804488 0.379259164746949 no 1279 0.387058436977633 1883 877370 SGTC_2113 5491891 107.031 µM 0.28515835979381 0.380008687113377 no 1280 0.387761410264035 1724 789979 SGTC_2026 5148700 152 µM 0.284373547829236 0.380329267412425 no 1281 0.388062064164999 1782 79838 SGTC_2738 aclarubicin 5.55 µM 0.282672399310494 0.381024435212904 no 1282 0.388713987922557 1872 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_137 0438-0332 85.389 µM 0.282279897554709 0.381184884172372 no 1283 0.388864449249032 1850 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1575 cyproterone acetate 48 µM 0.280812429034122 0.381784944521696 no 1284 0.389427135033796 1747 9880 An androgen receptor antagonist and liver toxin. SGTC_2089 5281248 129.67 µM 0.279353916159121 0.38238162442548 no 1285 0.389986616672654 1767 2737878 SGTC_274 sirtinol 40.1 µM 0.278587386939063 0.382695324822056 no 1286 0.390280746703396 1757 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1547 harmine 94.2 µM 0.277482152306413 0.383147775130367 no 1287 0.390704954186262 1795 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2807 7945238 51.95 µM 0.277332499332573 0.38320905089372 no 1288 0.3907624035058 1830 17148797 SGTC_1298 1079-1278 263 µM 0.277170912945019 0.383275216102382 no 1289 0.390824436544081 1815 2840950 SGTC_207 4185-0010 4.486 µM 0.275944442505879 0.383777533093582 no 1290 0.391295369196814 1933 3761753 SGTC_1198 1612-1005 86.7 µM 0.275916403119655 0.383789019277832 no 1291 0.391306137455974 1915 6998509 SGTC_1843 st055809 45.5 µM 0.273677663448366 0.384706435697082 no 1292 0.392166172303444 1824 16413835 SGTC_2545 solidagenone 89.61 µM 0.273374217159478 0.384830835223715 no 1293 0.392282784965935 1840 6708572 An anti ulcer agent SGTC_2418 pentamidine 31.67 µM 0.272736636946625 0.385092253462808 no 1294 0.392527834877679 1924 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3048 9093155 49.47 µM 0.27265570485933 0.385125440671037 no 1295 0.392558943662215 1941 25236002 SGTC_1664 st014217 9.02 µM 0.270979881912781 0.385812821456167 no 1296 0.393203252734575 1935 3982782 SGTC_1521 st012942 49.4 µM 0.270885816988624 0.385851415194648 no 1297 0.393239426870577 1982 24207259 SGTC_1373 2887-0003 58.5 µM 0.270286283484843 0.386097423316291 no 1298 0.393470008492236 1825 776948 SGTC_1221 2958-7315 257 µM 0.269515580320107 0.386413735201446 no 1299 0.393766477144349 1867 4562705 SGTC_1238 0333-0287 48.8 µM 0.268866640170984 0.386680131683186 no 1300 0.394016154627074 1817 7226 SGTC_846 0335-0850 148 µM 0.268087086670765 0.387000216867942 no 1301 0.394316142740022 1867 6819598 SGTC_1692 fluoroquinolonic acid 71 µM 0.26717471346827 0.387374935521702 no 1302 0.39466732221057 1885 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2369 9071472 200 µM 0.26535317080711 0.388123370659663 no 1303 0.39536870383011 1863 17296037 SGTC_183 3914-0051 30.55 µM 0.26458333943237 0.388439803976067 no 1304 0.395665228035671 1984 1596232 SGTC_2603 homopterocarpin 100 µM 0.264338872584256 0.388540305712472 no 1305 0.395759404597274 1822 101795 A weak amylase inhibitor. SGTC_3090 9117696 49.47 µM 0.263757740668998 0.388779242347315 no 1306 0.395983299885505 1944 7923821 SGTC_766 1391-0721 126 µM 0.263320260951038 0.388959143099114 no 1307 0.39615187229757 1937 1020919 YIL115C NUP159 SGTC_401 neomycin 50 µM 0.262844149606767 0.389154957035557 no 1308 0.396335352555969 1864 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1343 1487-0095 224 µM 0.259848558672299 0.390387620478112 no 1309 0.397490296349442 1970 4560101 YGL055W OLE1 SGTC_2328 6201408 200 µM 0.259677312983831 0.390458120244412 no 1310 0.397556347032619 1814 2890418 SGTC_3219 9131112 49.47 µM 0.259058942883802 0.390712725660731 no 1311 0.397794881229836 1915 17612988 YMR079W SEC14 SGTC_429 1112-0049 25.5 µM 0.259034568227041 0.39072276255238 no 1312 0.397804284455547 1786 2836170 SGTC_305 1682-2595 20.8 µM 0.258021896537461 0.391139820429912 no 1313 0.398195004130113 1882 226033 SGTC_1457 k015-0032 57.3 µM 0.257871815837918 0.391201640206705 no 1314 0.398252918545383 1825 4302660 SGTC_3258 9138477 49.47 µM 0.25560270347075 0.392136644925033 no 1315 0.399128815333734 1881 4970355 SGTC_457 grayanotoxin iii 135 µM 0.255019540381631 0.392377042507268 no 1316 0.399354003524831 1895 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1626 st003712 1.76 µM 0.253977499403672 0.392806705746931 no 1317 0.39975647057234 1892 24207035 SGTC_2233 sulbentine 40.3845 µM 0.251055511710827 0.394012219946582 no 1318 0.400885595511229 1930 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1230 0170-0365 3.77 µM 0.250879049327805 0.394085055065792 no 1319 0.400953811358596 1973 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1529 apigenin 74 µM 0.250822119331964 0.394108553799334 no 1320 0.400975819684429 1977 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1447 4239-0816 81.9 µM 0.248292423326273 0.395153112769286 no 1321 0.401954080404624 1781 1341554 SGTC_897 1000-0139 31.4 µM 0.248215319916952 0.395184962091438 no 1322 0.401983906806589 1984 6151020 SGTC_1952 st077036 64.1 µM 0.247308736382044 0.395559499569083 no 1323 0.402334649048559 1994 2937007 SGTC_3170 9103054 49.47 µM 0.247240477897354 0.395587703153354 no 1324 0.402361060319406 1858 16432970 SGTC_2788 5282734 71.43 µM 0.244821235617109 0.396587657021829 no 1325 0.403297425274003 1966 743706 SGTC_475 α-linolenic acid 10 µM 0.244252930504539 0.396822655510605 no 1326 0.403517467773265 1970 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_61 0978-8327 98.565 µM 0.243908990896521 0.39696489536445 no 1327 0.403650652859728 2024 6150059 YHR072W ERG7 SGTC_707 0865-0008 204 µM 0.243518665110131 0.397126335316916 no 1328 0.40380181378294 1925 723043 SGTC_598 3937-0236 20.2 µM 0.242418981004451 0.39758126277544 no 1329 0.404227764109769 1931 1379313 SGTC_2914 7968218 45.32 µM 0.241820732278665 0.397828810381216 no 1330 0.404459536783607 1969 2977111 SGTC_124 0136-0217 7.121 µM 0.241612602219407 0.397914941566464 no 1331 0.404540178102593 2048 3976905 SGTC_1128 3448-9350 235 µM 0.23853284705199 0.399190026734164 no 1332 0.405733921092588 1823 619386 SGTC_2526 patulin 37.61 µM 0.237730151797959 0.399522537281775 no 1333 0.406045198116734 1897 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2847 9005661 71.43 µM 0.23766641706132 0.399548942049883 no 1334 0.406069916345039 1973 2991449 SGTC_2074 5212007 75.395 µM 0.237258396328707 0.399717992506233 no 1335 0.406228167799406 2034 758611 SGTC_1744 st037937 38.9 µM 0.237241772117005 0.399724880620162 no 1336 0.40623461584989 1940 1016152 SGTC_2784 7567673 72.73 µM 0.236282971450848 0.400122205019746 no 1337 0.406606549849316 1896 3471247 SGTC_2274 7947094 46.08 µM 0.235259095743959 0.400546610508052 no 1338 0.407003820526012 2016 2971028 SGTC_1090 efavirenz 20.7 µM 0.234177265621143 0.400995166207766 no 1339 0.40742368188229 1936 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2260 7964312 200 µM 0.233502216430071 0.401275125838275 no 1340 0.40768572432887 2009 231951 SGTC_3110 9122132 49.47 µM 0.233302020410143 0.401358161842161 no 1341 0.40776344491585 1980 918317 SGTC_442 cape 100 µM 0.231957392000284 0.401915993345744 no 1342 0.408285553762222 2015 5281787 SGTC_1004 4084-0029 199 µM 0.229586476002958 0.402900076004993 no 1343 0.40920655838773 2015 716894 YLR208W SEC13 SGTC_573 3702-0553 84.7 µM 0.229471350716237 0.402947876121936 no 1344 0.409251292694224 1889 1222756 SGTC_87 0100-0052 35.5 µM 0.228988654659054 0.403148307717834 no 1345 0.409438867069502 1926 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1096 rimcazole 32.2 µM 0.227504212593319 0.403764857115561 no 1346 0.410015846969106 1891 18528119 A dopamine reuptake inhibitor. SGTC_579 4491-1009 110 µM 0.226833588383806 0.404043473263985 no 1347 0.41027657231248 2084 1271041 SGTC_3017 9080681 49.47 µM 0.226498872381606 0.404182551905282 no 1348 0.410406718077283 1869 16451914 SGTC_2954 9074818 52.69 µM 0.225210737545627 0.404717900715639 no 1349 0.410907668326015 1945 16648742 SGTC_767 0929-0023 86 µM 0.224387754832454 0.405060025781813 no 1350 0.411227799005321 1955 1204563 SGTC_3238 9133470 49.47 µM 0.223928480000649 0.405250984121091 no 1351 0.411406477276447 2025 3534688 SGTC_477 mead ethanolamide 10 µM 0.223225914468308 0.405543142057678 no 1352 0.411679841961663 1984 16061185 SGTC_610 4215-0184 155 µM 0.222407049684303 0.405883728797199 no 1353 0.411998512195774 1923 5605015 SGTC_1817 st052116 64.4 µM 0.220924680385056 0.406500465051285 no 1354 0.412575540007818 2000 4361398 SGTC_372 0155-0182 15.9 µM 0.219898677779191 0.406927466980296 no 1355 0.412975033045104 1957 771486 SGTC_2126 5251174 33.877 µM 0.217618645402575 0.407876766723116 no 1356 0.413863127856304 2056 790722 SGTC_3045 9092950 49.47 µM 0.216414789968609 0.408378214927585 no 1357 0.414332219348429 2058 44120432 SGTC_1272 0839-0021 27 µM 0.216075036627253 0.408519761352103 no 1358 0.414464628984213 1940 5027250 SGTC_1402 3909-7673 35.9 µM 0.215727903920565 0.40866439445937 no 1359 0.41459992456691 1941 5328014 SGTC_1294 1000-1494 117 µM 0.215293764174538 0.4088452966218 no 1360 0.414769145554098 1869 712797 YDL207W GLE1 SGTC_2638 epoxomicin 18 µM 0.215204967949174 0.408882299610945 no 1361 0.414803758904715 2032 9915668 A protesome inhibitor. SGTC_1841 st054148 70 µM 0.214795716954686 0.409052852376007 no 1362 0.414963296169952 1889 675442 SGTC_868 0527-0199 213 µM 0.213863815443053 0.409441280640373 no 1363 0.415326629233063 1924 2849450 SGTC_1803 st050068 52.4 µM 0.213773525242358 0.409478919461885 no 1364 0.415361835749434 1982 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2587 piperic acid 92.2 µM 0.211705144631315 0.410341382699623 no 1365 0.416168537119966 1887 5370536 SGTC_3142 9086498 49.47 µM 0.211272397725844 0.410521882403394 no 1366 0.41633736010706 2068 25236367 SGTC_1862 st057513 3.81 µM 0.211058654590933 0.410611042138955 no 1367 0.416420751159205 1926 5393163 SGTC_1947 st076332 61.6 µM 0.210896700297817 0.410678602014116 no 1368 0.416483939501686 2033 24208416 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.21018553214139 0.410975299972684 no 1369 0.416761435517211 1958 521171 SGTC_3136 9095672 49.47 µM 0.209028325713031 0.411458193028298 no 1370 0.417213063145604 2081 17217380 SGTC_432 NS 1619 61.3 µM 0.207999705635299 0.411887540673818 no 1371 0.417614598598213 1934 4552 A K+/calcium channel activator. SGTC_2470 5664817 21.68 µM 0.207512567951046 0.412090909558707 no 1372 0.417804789241244 2008 2859561 SGTC_900 1112-0045 141 µM 0.20639017871832 0.412559571276227 no 1373 0.418243070968603 2053 56211 YIL048W NEO1 SGTC_464 bw-b 70c 158 µM 0.205118035463649 0.413090914592577 no 1374 0.418739952875051 2027 5353454 SGTC_2646 retinol 96.75 µM 0.204281341006971 0.413440468401799 no 1375 0.419066825123071 1983 445354 A vitamin A analog and teratogen. SGTC_2832 7992762 51.95 µM 0.202307627996139 0.4142653166501 no 1376 0.419838118497151 1741 2985177 SGTC_1261 0712-0010 12.7 µM 0.199585801848095 0.415403433963325 no 1377 0.420902266426344 2050 2840123 SGTC_2593 nobiletin 86.24 µM 0.198673166226421 0.415785207207355 no 1378 0.421259207910588 1902 72344 An anti-infammatory. SGTC_3033 9090887 49.47 µM 0.197298658085473 0.416360340633037 no 1379 0.421796914700207 1914 19325384 SGTC_966 1300-0360 30.2 µM 0.196785101483859 0.416575273400334 no 1380 0.42199785522253 1923 70588 SGTC_2083 5306046 65.942 µM 0.196434977663995 0.41672182088332 no 1381 0.422134860654029 1941 539837 SGTC_999 SEC7.066 22.7 µM 0.196286159760192 0.416784113465788 no 1382 0.422193096796453 1973 740511 YDR170C SEC7 SGTC_1955 wogonin 32.4 µM 0.196239230313377 0.416803757748254 no 1383 0.422211461807601 2040 5281703 A flavanone. SGTC_1605 st000082 49.1 µM 0.196069037259022 0.416875000910787 no 1384 0.422278065275724 2016 1114022 SGTC_3059 1327-0034 3 µM 0.195901741751365 0.416945033814993 no 1385 0.42234353698205 1928 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3003 9075612 71.4286 µM 0.195682664785976 0.417036747352696 no 1386 0.422429276795007 1965 6501993 SGTC_2232 chlorophetanol 41.5365 µM 0.194699152985889 0.417448536510149 no 1387 0.422814237520887 2039 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_546 peri-Naphthalide 147 µM 0.194088472118267 0.417704269696607 no 1388 0.423053303956314 2013 223824 A penicillin ester. SGTC_3021 9087658 49.47 µM 0.193482453956476 0.417958084704972 no 1389 0.423290573071677 2087 25237042 SGTC_810 3825-7150 143 µM 0.193432834877751 0.417978867885792 no 1390 0.423310001239217 2106 22330411 YGL099W LSG1 SGTC_2420 aureobasidin a 50 nM 0.192767951650664 0.418257379379278 no 1391 0.423570351789959 2069 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_725 1497-0963 19 µM 0.191225759414698 0.41890354252132 no 1392 0.424174361448084 2085 3549977 SGTC_1456 k015-0012 13 µM 0.190433591369769 0.419235538203568 no 1393 0.424484688580316 2123 2989616 SGTC_1074 carmofur 3.8 µM 0.189037324733539 0.419820850003057 no 1394 0.425031781621602 2058 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2614 arthonioic acid 13.39 µM 0.187933548478739 0.420283676123362 no 1395 0.425464371699149 2033 6710684 SGTC_1072 oxiconazole 14.9 nM 0.187629545288543 0.42041116755941 no 1396 0.425583531886943 2034 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2191 5911152 200 µM 0.186831500597493 0.420745887507355 no 1397 0.425896373929419 1986 2875902 SGTC_3155 9099265 49.47 µM 0.185364705919346 0.421361247254673 no 1398 0.426471494631955 2014 25236499 SGTC_923 1900-2434 73.3 µM 0.184927415233094 0.421544739682247 no 1399 0.426642983797014 1927 5910570 SGTC_2175 5807670 165.306 µM 0.18467615680856 0.421650178446714 no 1400 0.426741524294285 2078 241186 SGTC_2860 9025725 38.96 µM 0.183151718380779 0.422290018078434 no 1401 0.42733948831264 1877 40546248 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.183134227033703 0.422297360766973 no 1402 0.427346350299973 2009 97141 SGTC_1017 4239-0030 168 µM 0.182611347885863 0.422516872542191 no 1403 0.427551489872707 1888 1149593 SGTC_390 dec-rvkr-cmk 16.7 µM 0.182598606233506 0.422522221961722 no 1404 0.427556489010809 2007 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1338 1486-1223 76 µM 0.182021014035285 0.422764731638582 no 1405 0.42778311728128 2048 3444526 SGTC_631 k072-0230 41.5 µM 0.182003698401392 0.422772002287497 no 1406 0.42778991173741 2034 5773147 SGTC_559 1550-0661 158 µM 0.178152622012448 0.424389677088388 no 1407 0.429301558288253 2015 5830875 SGTC_273 hydroxyurea 18.1 mM 0.177343711667946 0.424729629098365 no 1408 0.429619208979324 1976 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1895 st058434 18.3 µM 0.176308861820362 0.425164615865343 no 1409 0.43002565018218 2122 5393175 SGTC_235 0330-0087 5 mM 0.174894548100852 0.425759253005077 no 1410 0.430581247117661 1987 46494818 YHR062C RPP1 SGTC_246 cycloheximide 667 µM 0.174401595771667 0.42596655071326 no 1411 0.430774930147583 1991 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_764 1951-2361 146 µM 0.174333670533373 0.42599511643182 no 1412 0.430801619563904 1904 5438930 SGTC_1996 st072960 66.8 µM 0.174165849250587 0.426065694743009 no 1413 0.430867561829565 2110 1719405 SGTC_2094 5332512 191.667 µM 0.174036172229335 0.426120232863796 no 1414 0.430918517334126 2076 755774 SGTC_944 3370-0224 231 µM 0.173431004049071 0.426374766440786 no 1415 0.431156328318653 1964 4580514 SGTC_833 3852-0053 558 µM 0.172185475435283 0.426898731853906 no 1416 0.431645858133257 2043 3123681 SGTC_2068 5226020 147 µM 0.170814780249673 0.427475501062352 no 1417 0.432184703461297 1969 1810509 SGTC_2475 5812728 15.03 µM 0.170752280442586 0.427501803805084 no 1418 0.432209276292983 2108 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2504 purpurogallin 52.29 µM 0.170482365658372 0.42761539984112 no 1419 0.432315400760122 1951 5281571 An antioxidant. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.169727517009707 0.427933116432222 no 1420 0.432612216298223 2022 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2883 9059145 45.46 µM 0.169428391028253 0.428059031812306 no 1421 0.432729846750425 2002 16476510 SGTC_2445 5742597 35.57 µM 0.168929279112956 0.428269146436887 no 1422 0.432926134377254 1979 1774255 SGTC_1149 3909-7961 23.3 µM 0.166979373984003 0.429090205988899 no 1423 0.43369313911896 1936 735261 SGTC_3332 9141069 11.198 µM 0.166951288118542 0.429102034542151 no 1424 0.433704188663369 1946 17332883 SGTC_3242 9133940 49.47 µM 0.166791961331823 0.429169137306691 no 1425 0.433766872006443 2067 17248444 SGTC_3349 9149703 23.001 µM 0.166129336620389 0.429448233158817 no 1426 0.434027583826343 2095 4910494 SGTC_2986 9022445 71.43 µM 0.163774286801348 0.430440458675455 no 1427 0.434954417247489 2115 6459286 SGTC_493 zm226600 134 µM 0.163113799053725 0.430718813388111 no 1428 0.435214417615165 2063 5240098 A potassium channel opener. YCR052W RSC6 SGTC_485 niflumic acid 177 µM 0.161480111785142 0.431407459064647 no 1429 0.43585763714095 2078 4488 A COX2 inhibitor. SGTC_2940 9060638 45.86 µM 0.158963288620949 0.43246877906795 no 1430 0.436848898715021 2005 4027022 SGTC_1830 st055982 50.3 µM 0.158895266498092 0.432497470139027 no 1431 0.436875695051975 2152 455313 An antimicrobial agent. SGTC_753 1322-0200 289 µM 0.158839884548351 0.432520829970662 no 1432 0.436897512188434 2049 5403907 SGTC_1082 camptothecin 424.86 nM 0.158758516510607 0.432555151033097 no 1433 0.43692956661899 1887 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2678 equilin 100 µM 0.15801152043287 0.432870257947568 no 1434 0.437223860384688 2119 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.157099830437854 0.43325489586908 no 1435 0.437583085607056 2081 5357218 A potent inhibitor of glutathione S-transferases. SGTC_89 0302-0250 142.109 µM 0.155919686778902 0.433752887040896 no 1436 0.438048163643976 2166 4203518 YLR208W SEC13 SGTC_3342 9147791 14.508 µM 0.154560673339335 0.434326487049195 no 1437 0.43858383773572 2096 1838168 SGTC_496 calpeptin 138 µM 0.154412852069787 0.434388886464192 no 1438 0.438642110352721 2020 73364 A calpain inhibitor. SGTC_122 0236-0016 402.397 µM 0.153823857046879 0.434637533646802 no 1439 0.438874311254438 2128 6808838 SGTC_2488 5268135 45.7 µM 0.151469296462208 0.435631780439604 no 1440 0.439802764619358 2081 1270356 YLR208W SEC13 SGTC_1905 st060207 84.5 µM 0.151454599265653 0.435637987825167 no 1441 0.439808561082167 2000 1948547 SGTC_2772 vinpocetine 57.06 µM 0.150623338828852 0.435989097828082 no 1442 0.440136424856847 2115 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2132 5317594 122.667 µM 0.149278392013414 0.436557286792637 no 1443 0.440666982447272 2058 794577 SGTC_1412 3909-8563 178 µM 0.149002019597195 0.436674059899283 no 1444 0.440776019673996 2158 23767530 SGTC_919 tnp00227 403.569 nM 0.148468472472374 0.436899510282673 no 1445 0.440986532749324 2030 1269246 A methoxyflavone. YNL221C POP1 SGTC_1863 st057641 20.1 µM 0.148388622950328 0.436933252469991 no 1446 0.441018039122193 2191 3921635 SGTC_462 ag-879 158 µM 0.14821044596585 0.437008546762106 no 1447 0.44108834408849 2152 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2792 7535235 81.82 µM 0.147655946573292 0.437242882518804 no 1448 0.441307149991739 1992 1281891 SGTC_730 1436-0052 41.2 µM 0.147401622001411 0.437350369431463 no 1449 0.441407512667863 2179 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2779 methotrexate 400 µM 0.146961763055587 0.437536280900584 no 1450 0.441581100608154 2147 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_751 0833-0568 350 µM 0.146548841364283 0.43771081957868 no 1451 0.441744068119824 2049 6954252 SGTC_1768 st044301 37.178 µM 0.146056338339323 0.437919012493179 no 1452 0.441938456833992 2019 3931349 SGTC_2455 5377712 9.75 µM 0.145454522539268 0.438173437881018 no 1453 0.442176009784418 1963 2243908 SGTC_2874 9043904 71.43 µM 0.144697447720176 0.438493537306903 no 1454 0.442474877187643 2020 4463428 SGTC_937 3122-0005 46.7 µM 0.143946092928821 0.438811258028906 no 1455 0.442771518890402 2150 759535 SGTC_151 3013-0144 2.285 µM 0.142720568338008 0.43932957250415 no 1456 0.443255435913615 2156 906558 YHR107C CDC12 SGTC_694 1315-0438 43.2 µM 0.141918304433512 0.439668932574734 no 1457 0.443572267906108 2090 6793154 SGTC_2871 9038510 12.99 µM 0.141693610321974 0.439763986825412 no 1458 0.443661011120948 2177 4945164 SGTC_2424 5537928 59.2 µM 0.141625331043631 0.439792872274283 no 1459 0.443687978665588 2040 5382802 SGTC_724 3910-0327 137 µM 0.141353519821701 0.439907864790322 no 1460 0.443795335654195 2035 2885483 SGTC_1342 1486-1464 234 µM 0.140915181754629 0.440093318866304 no 1461 0.443968474259725 2102 3253938 SGTC_3304 9125678 46.087 µM 0.140340504950347 0.440336475665532 no 1462 0.444195481329506 2056 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3205 9113483 49.47 µM 0.137805074056194 0.441409532614382 no 1463 0.44519723705329 2139 17018033 SGTC_1774 st048371 48.465 µM 0.137407794485217 0.441577710324062 no 1464 0.445354235189944 2084 4242727 SGTC_1426 4048-4480 71.7 µM 0.137213925740859 0.441659783312084 no 1465 0.445430851937068 2147 14224343 SGTC_2014 4013930 200 µM 0.137195586053289 0.441667547421335 no 1466 0.445438099870073 2195 64556 SGTC_1950 st077106 7.18 µM 0.136302210752725 0.442045785059389 no 1467 0.445791188134141 2008 13831864 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.135874910890706 0.442226714171368 no 1468 0.445960084858705 2035 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3153 9100258 49.47 µM 0.135739461531329 0.442284069228576 no 1469 0.446013625312243 2020 25236848 SGTC_3337 9144342 33.5465 µM 0.135268040764453 0.442483698387654 no 1470 0.446199976289025 2126 17682949 SGTC_1674 st016616 23.6 µM 0.132633166693698 0.443599737082557 no 1471 0.447241750457008 2059 625830 SGTC_1243 0416-0003 5.65 µM 0.132506139444567 0.443653552673117 no 1472 0.447291983635435 2047 2141977 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.130240958535591 0.444613378982048 no 1473 0.448187895155565 1961 641818 YHR062C RPP1 SGTC_1948 st076329 66.6 µM 0.129870573886614 0.444770353317983 no 1474 0.448334412859552 2181 24208413 SGTC_2360 9040895 200 µM 0.12949865477566 0.444927986696785 no 1475 0.448481544661726 2060 4914414 SGTC_1237 0330-0133 46.1 µM 0.128616022541973 0.445302114417972 no 1476 0.448830743729375 2094 X1237 YHR072W ERG7 SGTC_734 2023-0417 80 µM 0.128550871725818 0.445329732301486 no 1477 0.448856521163065 2131 3935732 SGTC_594 1487-1584 10.8 µM 0.127759670799126 0.4456651490074 no 1478 0.449169583241934 2063 5013332 SGTC_2314 7727897 200 µM 0.127624339105858 0.445722524569487 no 1479 0.449223134409189 2083 900724 SGTC_244 nsc-207895 1.295 µM 0.127173018768831 0.445913875674677 no 1480 0.449401729934839 2133 42640 SGTC_58 0957-0393 9 µM 0.126452100171344 0.446219557350904 no 1481 0.449687031562002 2117 6997992 SGTC_2351 9026858 72.31 µM 0.126213424053538 0.446320767113018 no 1482 0.449781492742179 2120 1409300 SGTC_1864 st057645 30.4 µM 0.126036859725662 0.446395640841508 no 1483 0.449851373684056 2206 688666 SGTC_830 4076-0286 57.8 µM 0.125971430841239 0.446423387047692 no 1484 0.449877269638647 2095 6866659 SGTC_1910 st062352 60.4 µM 0.124174813384481 0.44718537457944 no 1485 0.450588431940761 2125 2245730 SGTC_1038 k292-0204 154 µM 0.12401147038411 0.44725466188294 no 1486 0.450653096559338 2165 4454212 SGTC_2551 apiole 73.87 µM 0.122941488007016 0.447708569798334 no 1487 0.451076716063581 2197 10659 A possible DNA adduct former. SGTC_2531 methyl deoxycholate 70.07 µM 0.122007528523139 0.448104830084717 no 1488 0.451446527959349 2093 16667744 Haematoxylin. SGTC_2350 9023895 38.85 µM 0.120821065419361 0.448608297230692 no 1489 0.451916382271241 2137 2997209 SGTC_1242 0402-0103 60.1 µM 0.120768082638029 0.44863078203239 no 1490 0.451937365695024 2153 432868 SGTC_1604 st002052 72.4 µM 0.120553913353534 0.448721672748655 no 1491 0.45202218716361 2104 6254834 YHR062C RPP1 SGTC_2305 7443522 69.23 µM 0.120113727196928 0.448908490591699 no 1492 0.452196529194637 2120 5415886 SGTC_3011 9081274 71.4286 µM 0.11952904547465 0.449156650794143 no 1493 0.452428115011757 2088 6625322 SGTC_2429 5902844 64.44 µM 0.118406721743069 0.449633061484854 no 1494 0.4528727000335 2181 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_165 k038-0023 64.381 µM 0.118190348276556 0.449724917357758 no 1495 0.452958418657609 2139 46368543 SGTC_2448 5185112 27.17 µM 0.117877986427784 0.44985752741659 no 1496 0.453082167954278 2081 5718189 SGTC_2567 aureobasidin a 60 nM 0.117505676327648 0.450015595211748 no 1497 0.453229673074279 2081 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2499 avocadenofuran 51.48 µM 0.11738267822795 0.450067816969101 no 1498 0.453278404972231 2181 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2474 5321570 43.32 µM 0.11723142901059 0.450132034593028 no 1499 0.453338330939162 2174 2841384 SGTC_1507 4075-3230 155 µM 0.117057482846932 0.450205890535397 no 1500 0.453407250903956 2213 659771 SGTC_1433 4060-0023 7.6 µM 0.11570595734826 0.45077979440021 no 1501 0.45394279234358 2171 3840627 SGTC_352 k048-0007 5.11 µM 0.1151587100533 0.45101220362476 no 1502 0.454159662742706 2192 6811911 SGTC_222 nsc-310342 10.666 µM 0.114943115265437 0.451103768707131 no 1503 0.454245105254434 2217 432556 SGTC_3073 9114972 49.47 µM 0.112707105983675 0.452053574885532 no 1504 0.455131383695312 2229 41905075 SGTC_47 0149-0135 24.25 µM 0.112327476346054 0.452214860376744 no 1505 0.455281878344513 2203 5239155 SGTC_1169 aniline yellow 25.8 µM 0.1119073096557 0.452393377210675 no 1506 0.455448450372927 2154 6051 A DNA damaging agent. SGTC_1900 st060200 72.8 µM 0.111483566596237 0.452573423289221 no 1507 0.455616448159418 2087 688945 SGTC_407 eburnamonine 100 µM 0.111335884045866 0.452636175080318 no 1508 0.455675000463557 2073 3195 SGTC_3290 9121031 71.43 µM 0.111078338113897 0.452745611749372 no 1509 0.455777113054172 2109 17014854 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.110685181305896 0.452912679243899 no 1510 0.455932998686604 2117 688669 SGTC_1467 k284-1082 293 µM 0.110081669553881 0.45316915087752 no 1511 0.456172302687741 2235 3334705 SGTC_189 3970-0742 2.116 µM 0.109528750277246 0.45340413960838 no 1512 0.456391559758279 2222 2891807 SGTC_1757 st041620 31.8375 µM 0.10842891534479 0.45387161397921 no 1513 0.456827732608443 2095 5289815 SGTC_3027 9089541 49.47 µM 0.107649222134968 0.454203053912057 no 1514 0.457136975103616 2130 9943819 SGTC_50 0929-0078 56.389 µM 0.107554024712558 0.454243523591542 no 1515 0.457174734157225 2149 1377751 SGTC_638 3970-0837 4.09 µM 0.10714525635707 0.454417301803123 no 1516 0.457336872204307 2101 4118451 YLR208W SEC13 SGTC_1550 gossypolone 36.6 µM 0.10545825065326 0.455134584382132 no 1517 0.458006098178215 2223 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2858 9025781 8.96 µM 0.105269188391947 0.45521497920108 no 1518 0.458081105602145 2215 4894980 YPL153C RAD53 SGTC_1401 3807-4679 7.6 µM 0.104607723848235 0.455496267739609 no 1519 0.458343542795835 2207 3291456 SGTC_1341 1486-1360 280 µM 0.104433499384462 0.455570360606096 no 1520 0.458412669677174 2157 3976547 SGTC_1106 tegaserod maleate 11.7 µM 0.10400093533251 0.455754324860852 no 1521 0.458584303154492 2121 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_32 0928-0142 34.1 µM 0.103206169125144 0.45609235400688 no 1522 0.458899671903317 2222 2244242 SGTC_714 4296-0578 26.1 µM 0.102896190400799 0.456224202467922 no 1523 0.459022680636456 2198 1589775 SGTC_378 3970-0959 8.33 µM 0.102572684456132 0.456361809829215 no 1524 0.459151061554909 2146 6615653 SGTC_992 3909-8734 162 µM 0.102198572330992 0.456520949696908 no 1525 0.459299530469192 2138 4288319 SGTC_3141 9094609 49.47 µM 0.101167922124362 0.456959403820104 no 1526 0.459708580237784 2040 25236309 YDL196W YDL196W SGTC_184 1494-0393 24.714 µM 0.101141628725321 0.456970590115847 no 1527 0.45971901625736 2155 3090647 SGTC_3071 9117417 49.47 µM 0.101098654851217 0.456988873046635 no 1528 0.459736072924762 2229 45595590 YGL055W OLE1 SGTC_424 splitomicin 100 mM 0.100799061716939 0.45711633535421 no 1529 0.459854985844958 2021 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1204 4049-0315 18.3 µM 0.0999668816246137 0.457470410615803 no 1530 0.460185309168216 2181 588402 SGTC_1196 1588-0294 184 µM 0.0990707524189375 0.457851732633946 no 1531 0.460541047003399 2114 6144269 SGTC_2948 9070189 9.45 µM 0.0988548827682959 0.457943595569342 no 1532 0.460626745852962 2248 6473636 YDL196W YDL196W SGTC_2610 ononetin 44.17 µM 0.0980765076785022 0.458274850286697 no 1533 0.460935770866561 2138 259632 SGTC_1971 st069429 63.5 µM 0.0966151557607899 0.458896838984499 no 1534 0.461516010123516 2241 1246522 YGL099W LSG1 SGTC_1295 1013-0063 9.78 µM 0.0963206402357986 0.459022204547583 no 1535 0.461632959382132 2258 6826038 SGTC_1779 st039427 55 µM 0.0959999553278857 0.45915871418963 no 1536 0.461760304021504 2255 1124498 SGTC_914 3820-6779 408 µM 0.0959857726523848 0.459164751603947 no 1537 0.461765936081866 2210 2893481 SGTC_663 1486-0733 13.9 µM 0.0943949633814468 0.459842001661415 no 1538 0.462397708290871 2151 722445 YPR165W RHO1 SGTC_779 1360-0071 233 µM 0.0939114318066661 0.460047877170426 no 1539 0.4625897563526 2254 7566 SGTC_822 1487-0950 154 µM 0.0931714466433613 0.460362964849666 no 1540 0.462883678985751 2267 1958375 SGTC_3253 9135987 49.47 µM 0.0929302087814167 0.460465689971762 no 1541 0.462979503224006 2213 4182430 SGTC_342 k048-0088 23.3 µM 0.0926691770449423 0.460576846793266 no 1542 0.463083192383034 2208 6820570 SGTC_2117 5521686 200 µM 0.0925384677486646 0.460632508730814 no 1543 0.463135114740498 2178 803312 SGTC_1291 0993-0025 5.79 µM 0.0908324723662717 0.461359069158064 no 1544 0.46381285373855 2220 4353356 SGTC_1919 st067113 52.3 µM 0.0867873620131665 0.463082338250325 no 1545 0.465420266685231 2172 1268243 SGTC_2944 9067346 25.62 µM 0.0866415661589934 0.463144462294668 no 1546 0.465478212546656 2197 6473075 SGTC_2982 9019404 25.97 µM 0.0852559071781006 0.463734940335304 no 1547 0.466028972412317 2086 22333232 SGTC_1031 k035-0009 16 µM 0.085176272013699 0.463768878120694 no 1548 0.466060627102755 2248 5180959 SGTC_2492 derrusnin 100 µM 0.0849730122282771 0.46385550168915 no 1549 0.466141423106827 2173 1715307 Part of coumarin class of compounds. SGTC_1788 fluconazole 20 µM 0.0838861449607639 0.46431872273846 no 1550 0.46657347772522 2100 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1813 st051246 8.6015 µM 0.0831907623764346 0.464615119069427 no 1551 0.466849928917423 2262 5291959 SGTC_483 fpl-64176 144 µM 0.0811598732802377 0.465480866711473 no 1552 0.467657405342117 2249 3423 SGTC_252 miconazole 1.30953 nM 0.0807827696333092 0.465641640322171 no 1553 0.467807355560064 2275 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2888 9058547 12.99 µM 0.0802780765876219 0.465856818911157 no 1554 0.468008047138884 2236 16476514 SGTC_536 3852-0578 10.6 µM 0.0768593631342192 0.467314665395471 no 1555 0.469367712699279 2255 2869208 SGTC_1891 st059073 26.2 µM 0.0768199144541174 0.467331490145092 no 1556 0.469383404053763 2289 688754 SGTC_643 k048-0106 28.4 µM 0.0752701770980781 0.467992494591914 no 1557 0.469999874689362 2228 6763920 SGTC_623 k072-0108 16.9 µM 0.0750800050933125 0.468073614156566 no 1558 0.470075528269869 2201 5382803 SGTC_3178 9107506 49.47 µM 0.0749643395135553 0.468122952989734 no 1559 0.470121542486107 2238 8897194 SGTC_2529 gangaleoidin 93.61 µM 0.0738716045032244 0.468589099040856 no 1560 0.470556275210821 2240 4565183 SGTC_2200 6600604 21.907 µM 0.0737009630191723 0.468661896305663 no 1561 0.470624166248225 2261 2904777 SGTC_563 tetrahydrosecaminediol 614 µM 0.0736435814950245 0.468686376040023 no 1562 0.470646996124414 2273 334274 A psychoactive constituent of the cannabis plant. SGTC_1633 st005664 67.9 µM 0.0719689022776432 0.469400868612714 no 1563 0.47131332802127 2257 2063822 SGTC_1435 4092-0789 56.7 µM 0.0716439445964099 0.469539521487744 no 1564 0.471442633588748 2291 2248285 SGTC_1965 Pectolinarigenin 58.4 µM 0.0708071037764842 0.469896601516786 no 1565 0.471775639011111 2249 5320438 An anti-inflammatory. SGTC_2406 ethylparaben 405.7 µM 0.0702971003765634 0.470114231890585 no 1566 0.471978595181976 1971 8434 A possible steroid mimic. SGTC_3075 9116269 49.47 µM 0.0701468129997669 0.470178364733628 no 1567 0.472038403527638 2215 17015205 YNL244C SUI1 SGTC_1156 4092-0367 4.88 µM 0.0700338567097906 0.470226567614739 no 1568 0.472083356013771 2153 1357585 SGTC_2206 7254556 146.969 µM 0.068891834173397 0.470713937825513 no 1569 0.472537859231559 2275 4398905 SGTC_1064 honokiol 6.76 µM 0.0675599285431087 0.471282398023305 no 1570 0.473067977435636 2189 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_100 0086-0128 49.5915 µM 0.0673016266426775 0.471392648642382 no 1571 0.473170790976691 2235 93297 SGTC_337 1315-0038 354 µM 0.0672672808337607 0.471407308578654 no 1572 0.473184461991278 2198 1626437 SGTC_1701 st028638 40.4 µM 0.067018653606044 0.47151343212232 no 1573 0.473283426577627 2287 3490878 SGTC_2156 5649887 115 µM 0.066557736438593 0.471710174420032 no 1574 0.473466896266975 2254 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_438 sphingosine 6.67 µM 0.0659377830895518 0.471974812123515 no 1575 0.473713679733832 2246 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1993 st073995 70.8 µM 0.0655711957666145 0.472131302028834 no 1576 0.473859611096067 2204 3098394 SGTC_3190 9110366 49.47 µM 0.0653519359009963 0.472224902401208 no 1577 0.473946895909023 2291 17123768 SGTC_1748 st037455 53.6035 µM 0.0650155895602047 0.472368489080646 no 1578 0.474080793921049 2252 580690 SGTC_1540 guanosine 70.6 µM 0.0647890227381024 0.472465212769653 no 1579 0.474170990836682 2278 6802 Guanosine is a purine nucleoside SGTC_3025 9087895 49.47 µM 0.0640728119404772 0.472770981122165 no 1580 0.474456125139628 2294 17173641 SGTC_3095 9117207 49.47 µM 0.0632707550613995 0.473113418357775 no 1581 0.474775451584915 2285 17015229 SGTC_3319 9138450 16.7555 µM 0.0629909792457009 0.473232872998825 no 1582 0.47488684378798 2167 2029690 SGTC_1667 st014849 34.6 µM 0.0625760692142046 0.473410029726319 no 1583 0.475052043031079 2278 5348460 SGTC_887 0885-0007 9.62 µM 0.0619579517104607 0.473673960960273 no 1584 0.475298158653544 2281 5719458 SGTC_1789 tunicamycin 25 nM 0.0619127738358419 0.473693252006262 no 1585 0.475316147482281 2268 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1235 benzylparaben 21.5 µM 0.0594538471775051 0.474743310622355 no 1586 0.476295312513628 2256 7180 SGTC_1716 st033144 30.6155 µM 0.0588849668558747 0.474986270205597 no 1587 0.476521865992065 2297 674617 SGTC_2852 9023854 51.95 µM 0.0582028891358425 0.475277586821491 no 1588 0.476793509714054 2282 19798528 SGTC_977 1348-1378 135 µM 0.0581005893989525 0.475321280365961 no 1589 0.476834252457748 2303 X977 SGTC_3010 9080089 71.4286 µM 0.0572162851944583 0.475698990476884 no 1590 0.477186452851062 2297 17027233 SGTC_1127 asiatic acid 681.4 nM 0.0563768294333566 0.476057564821846 no 1591 0.477520807512928 2269 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_791 1348-1292 225 µM 0.0563283051159307 0.476078292626824 no 1592 0.477540135201779 2271 5437054 SGTC_29 0299-0004 12.984 µM 0.0553176326256656 0.476510029400097 no 1593 0.477942707435193 2295 16871 A napthoquinone isolated from Swertia calycina. SGTC_2696 st077691 74.316 µM 0.0540392963686392 0.477056145605858 no 1594 0.478451927995693 2264 757133 SGTC_1764 st044502 93.5 µM 0.0520588262260016 0.477902304152893 no 1595 0.479240910182491 2261 8407 SGTC_844 0330-0132 15.3 µM 0.0489919966984396 0.479212806428771 no 1596 0.480462836995854 2308 2828079 SGTC_1214 0358-0031 63.7 µM 0.0485903132496588 0.479384468744116 no 1597 0.480622894877366 2301 4301366 SGTC_1546 5-methoxyflavanone 78.7 µM 0.0480558073663552 0.479612899607811 no 1598 0.480835883049305 2325 147795 SGTC_3352 9151559 45.5865 µM 0.0480345378789287 0.479621989651239 no 1599 0.4808443585593 2275 17159339 SGTC_2415 st077333 57.7 µM 0.0478851232561533 0.47968584599769 no 1600 0.480903897855672 2345 2766255 SGTC_2568 diosmetin 100 µM 0.0477798596928205 0.479730833517858 no 1601 0.480945843928993 2328 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_839 0122-0028 230 µM 0.0471888455300603 0.479983425808033 no 1602 0.481181358798491 2267 759448 SGTC_181 1447-1644 8.07 µM 0.0469827527574842 0.480071509256589 no 1603 0.481263486826636 2321 534600 SGTC_2461 5755302 26.15 µM 0.0457235536702198 0.480609708243301 no 1604 0.481765295162779 2318 2788904 SGTC_1490 4089-0339 670 nM 0.0453769912006198 0.48075784004792 no 1605 0.48190341022721 2335 742542 SGTC_1397 3532-0190 20.1 µM 0.0453049387465075 0.480788637889159 no 1606 0.481932125465942 2288 5322280 SGTC_2457 5731572 11.68 µM 0.0444488151174362 0.481154585011801 no 1607 0.482273325618069 2334 2865357 SGTC_2376 9072922 81.32 µM 0.0443904255169014 0.481179544029215 no 1608 0.482296596728981 2277 17087968 SGTC_2656 pseudo-anisatin 100 µM 0.0440594496169159 0.481321023238214 no 1609 0.482428507946627 2317 6708809 A neurotoxin. SGTC_2339 9000433 200 µM 0.0434686545503614 0.481573570781326 no 1610 0.482663975471737 2281 2988954 SGTC_68 0986-0284 82.829 µM 0.0432281978189814 0.481676361096462 no 1611 0.482759813741769 2090 423278 YIL048W NEO1 SGTC_1939 st074455 53.6 µM 0.0428784786754392 0.48182586102161 no 1612 0.482899202249234 2340 1644229 SGTC_94 0334-0113 514.748 µM 0.0427957452807969 0.481861228737515 no 1613 0.482932177829071 2319 6795178 SGTC_1527 coumarin 137 µM 0.0425126585333038 0.481982246627708 no 1614 0.483045010411865 2287 323 A hepatotoxic, DNA x-linker. SGTC_1897 st060201 15 µM 0.0416106890592673 0.482367844197486 no 1615 0.483404525993132 2227 611878 SGTC_327 1273-0057 3.96 µM 0.0410979027796179 0.482587070904322 no 1616 0.483608923266071 2333 3108138 SGTC_675 1309-0189 238 µM 0.040790407511424 0.482718534000666 no 1617 0.483731493346321 2296 4246530 SGTC_2124 5246320 200 µM 0.0396383681224551 0.483211080658689 no 1618 0.484190719062503 2300 579342 SGTC_2687 chenodiol 100 µM 0.0379710414715648 0.4839239800837 no 1619 0.484855385464384 2295 5702181 A cholesterol synthesis inhibitor. SGTC_2879 9041815 71.43 µM 0.0367240242197676 0.484457201394347 no 1620 0.485352526501738 2336 4942971 SGTC_1249 0481-0015 10.2 µM 0.0356214274199242 0.484928692082579 no 1621 0.485792111276196 2326 4227577 SGTC_2931 9014674 55.67 µM 0.0352242277727128 0.485098547160623 no 1622 0.485950471623577 2336 2996810 SGTC_1724 st037281 8.293 µM 0.0313848495857821 0.486740520981556 no 1623 0.487481311739572 2336 574124 YDL195W SEC31 SGTC_2451 5856223 45.7 µM 0.0311418921554794 0.486844433615525 no 1624 0.487578190374539 2319 2179896 SGTC_2514 salinomycin 42.74 µM 0.0308176753389072 0.486983102192416 no 1625 0.487707472116351 2355 23682228 A polyether potassium ionophore. SGTC_2555 cholic acid 100 µM 0.030530748679559 0.487105822962184 no 1626 0.487821885452913 2300 6708657 Influences liver metabolism. SGTC_2887 9044784 58.44 µM 0.0303159925739417 0.487197676622893 no 1627 0.487907521102696 2356 6465546 SGTC_2073 5212005 126 µM 0.0296037103492733 0.487502332771848 no 1628 0.488191553090565 2353 691789 SGTC_2662 daunorubicin 22.37 µM 0.0292617952383321 0.487648578726772 no 1629 0.488327898414085 2329 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_346 4513-0042 7.16 µM 0.0280306686449713 0.488175177095749 no 1630 0.48881884535523 2356 2827372 SGTC_1167 k781-0610 148 µM 0.0280110854496239 0.48818355372156 no 1631 0.488826654853347 2320 4525169 SGTC_2774 tamoxifen 10.92 µM 0.0277004591251881 0.488316423462375 no 1632 0.488950528758138 2355 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2296 7971656 126.45 µM 0.0274780445330881 0.488411561622324 no 1633 0.48903922557956 2324 666570 SGTC_2814 7977482 42.97 µM 0.0269948781224958 0.488618239010579 no 1634 0.489231909605188 2347 6456762 SGTC_1453 4237-0541 195 µM 0.0264886071570731 0.488834802791754 no 1635 0.489433810291881 2357 739892 SGTC_2663 amphotericin b 100 µM 0.025409371506435 0.489296470340818 no 1636 0.489864218070611 2356 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2213 7173844 200 µM 0.0247780872623731 0.489566523194324 no 1637 0.490115984761714 2361 892728 SGTC_3149 9097855 49.47 µM 0.0229705977308439 0.490339763048584 no 1638 0.490836863185178 2351 25236625 YMR079W SEC14 SGTC_1608 st001473 40.5 µM 0.0225861870240132 0.490504217842878 no 1639 0.490990181088175 2343 7292267 SGTC_2383 9036125 200 µM 0.0225827818537283 0.490505674616473 no 1640 0.490991539208169 2328 79580 SGTC_2570 licareol 100 µM 0.0216843751777503 0.49089002837199 no 1641 0.491349863822642 2324 443158 SGTC_2745 rifampicin 24.3 µM 0.0215992719436582 0.490926437436571 no 1642 0.491383807150985 2360 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_176 1486-1328 72.834 µM 0.0215689643968126 0.490939403700394 no 1643 0.491395895296732 2340 22310231 SGTC_2783 7738165 71.43 µM 0.0211061070328316 0.491137425880627 no 1644 0.491580506636699 2338 17201110 SGTC_1344 1488-0097 29.1 µM 0.0205836501328552 0.491360948883568 no 1645 0.491788891503953 2340 747966 SGTC_2556 citropten 84.59 µM 0.0201216231507022 0.491558620386443 no 1646 0.49197317542828 2367 2775 A potential DNA crosslinker. SGTC_2989 9073649 71.4286 µM 0.0198509011229073 0.491674445822269 no 1647 0.4920811563224 2366 21367202 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0197432132224289 0.491720519099307 no 1648 0.49212410916103 2354 616764 SGTC_557 1315-0110 16.2 µM 0.0194148912600018 0.491860989308168 no 1649 0.492255065570065 2374 6833801 SGTC_2543 pimpinellin 60.67 µM 0.018688381979134 0.492171824682785 no 1650 0.4925448482377 2380 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3158 9100007 49.47 µM 0.0183374676191746 0.492321964322807 no 1651 0.492684818823968 2365 19297233 SGTC_2702 st077768 96.8 µM 0.0175911265841042 0.492641291905399 no 1652 0.49298251777157 2351 6484119 SGTC_350 k064-0020 19.8 µM 0.0171375565129695 0.492835357562696 no 1653 0.493163438770781 2374 2790705 SGTC_1977 st070720 65.3 µM 0.0160179499479756 0.493314402470466 no 1654 0.493610035772115 2299 682188 SGTC_416 estradiol valerate 100 µM 0.0149862122516922 0.493755859568407 no 1655 0.494021590088985 2357 13791 A steroid. SGTC_3211 9128781 49.47 µM 0.014401277306236 0.494006143361271 no 1656 0.494254920176627 2319 17194361 SGTC_1182 1222-0449 220 µM 0.0142250962622701 0.494081528723936 no 1657 0.494325199044689 2368 658318 SGTC_162 k030-0015 37.8 µM 0.0136803086603714 0.494314636914986 no 1658 0.494542516695736 2381 1809920 YMR134W ERG29 SGTC_2968 9090663 33.37 µM 0.013196625600116 0.494521600822655 no 1659 0.49473546089399 2327 25236811 SGTC_1954 st077032 68.9 µM 0.0123188173464171 0.494897211308985 no 1660 0.495085627211635 2284 698907 SGTC_527 4476-4215 268 µM 0.0104346804404341 0.495703440470023 no 1661 0.495837240331955 2314 4418754 SGTC_655 k060-0012 42 µM 0.00956442948055045 0.496075830203459 no 1662 0.496184402866443 2385 5994525 SGTC_528 3492-0019 172 µM 0.00817939756991819 0.496668507154988 no 1663 0.496736928865814 2383 2869262 SGTC_1687 st020778 55.3625 µM 0.00811213051774461 0.49669729198303 no 1664 0.496763763646694 2383 4259299 SGTC_81 0411-0046 9.971 µM 0.00700242010145586 0.497172160167293 no 1665 0.497206461386091 2395 12925265 SGTC_2294 7971431 200 µM 0.00629699822133771 0.49747402699777 no 1666 0.497487877771763 2393 5741572 SGTC_1048 3161-0300 24.5 µM 0.00440063152395089 0.49828553417982 no 1667 0.498244407690968 2393 2165101 SGTC_1765 st044815 90.4 µM 0.0042506020337922 0.498349736249314 no 1668 0.498304260237891 2386 645695 SGTC_3135 9127742 49.47 µM 0.00406304610828471 0.498429997053641 no 1669 0.49837908357996 2387 3643468 SGTC_776 4476-4378 112 µM 0.00356048187142225 0.498645059664119 no 1670 0.498579576244014 2372 2892008 SGTC_3058 9093861 49.47 µM 0.00326826027383637 0.498770110409887 no 1671 0.498696155114586 2392 17217477 SGTC_3339 9145883 14.936 µM 0.00278007595259267 0.498979019987179 no 1672 0.498890911588442 2395 2030670 SGTC_245 methotrexate 289.6 µM 0.0026082277398744 0.499052559365396 no 1673 0.498959468857412 2373 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1157 4092-0394 27.6 µM 0.00251459442949843 0.499092628084601 no 1674 0.498996823021224 2400 3659885 SGTC_392 N-ethylmaleimide 8.33 µM 0.00206751624222179 0.499283947407138 no 1675 0.499175180943193 2397 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2823 7987624 58.44 µM 0.00133710484230921 0.499596514576911 no 1676 0.499466572504021 2402 2239440 SGTC_2029 5175081 200 µM 0.00132053409286099 0.499603605751673 no 1677 0.499473183270758 2397 1380876 SGTC_2897 9048598 12.99 µM 0.000683315105062558 0.499876293021521 no 1678 0.499727396734968 2400 6467404 SGTC_2619 obliquin 87.91 µM 0.00010515523250959 0.499876293021521 no 1679 0.499958049131824 2403 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1148 3909-7663 27.7 µM -0.000210657061896612 0.499741146386444 no 1680 0.499915959991966 2407 4084526 SGTC_3329 9141233 27.5565 µM -0.000346564087233251 0.499682987236589 no 1681 0.499861740935502 2407 4909101 YNL103W MET4 SGTC_1354 1498-1681 81 µM -0.000820069071731865 0.499480358718722 no 1682 0.499672839811107 2414 5754243 SGTC_2827 7993847 71.43 µM -0.00119798519432873 0.499318635945036 no 1683 0.499522073169005 2410 2985692 SGTC_1964 st076914 61 µM -0.00188704267307942 0.499023765829632 no 1684 0.499247179339577 2412 24208661 SGTC_1158 4092-0494 91.8 µM -0.0024164261625961 0.498797225763439 no 1685 0.499035986374437 2426 1148199 SGTC_1293 1000-1278 195 µM -0.0030840676086629 0.498511521273543 no 1686 0.498769636985716 2411 678847 SGTC_264 promethazine 12.5 mM -0.00380100178264813 0.498204723750004 no 1687 0.498483623332359 2413 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1011 4112-3381 17.4 µM -0.00459554553181867 0.497864716021695 no 1688 0.498166649038952 2454 2877139 SGTC_474 dl-dihydrosphingosine 5 µM -0.00465855737926405 0.497837751534259 no 1689 0.49814151121794 2426 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2495 cafestol 54.53 µM -0.00471352247606915 0.497814230478866 no 1690 0.498119583557637 2439 16667697 An anti-infammatory. SGTC_69 0096-0274 206.684 µM -0.00532608188067186 0.497552100231958 no 1691 0.497875210794626 2461 6741392 SGTC_843 0310-0051 143 µM -0.00560633504169437 0.497432172894177 no 1692 0.497763407630164 2416 2065037 SGTC_2207 7258803 200 µM -0.00574561364251845 0.49737257218265 no 1693 0.497707844402624 2419 3666799 SGTC_1321 1326-2144 215 µM -0.00643631622460998 0.497077004587916 no 1694 0.497432299056316 2405 3513030 SGTC_1516 st013856 110 µM -0.00675193784968275 0.496941943325904 no 1695 0.497306386983504 2459 5281404 A mutagen and neurotoxin. SGTC_2907 7721985 69.9 µM -0.00775654582450611 0.496512052437584 no 1696 0.496905616949176 2422 3267881 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.00904201377703266 0.495961982189865 no 1697 0.496392807557251 2425 688664 SGTC_3173 9105693 49.47 µM -0.00944163488461093 0.495790980078738 no 1698 0.496233388610594 2432 17096658 SGTC_607 4491-0986 66.8 µM -0.00985226001648427 0.495615270034803 no 1699 0.496069580507708 2427 698981 YDR232W HEM1 SGTC_956 1185-0240 191 µM -0.0105748344463789 0.495306076275745 no 1700 0.495781330058195 2433 1416193 SGTC_1482 3346-2049 8.48 µM -0.0108643965745412 0.49518217175483 no 1701 0.495665818119809 2453 3826804 SGTC_1973 st070275 50.2 µM -0.0108650120678741 0.49518190838384 no 1702 0.495665572587987 2419 17118334 SGTC_2491 paeonol 100 µM -0.0122406113596309 0.494593291794271 no 1703 0.495116824534104 2423 11092 Increases levels of cortical cytochrome oxidase. SGTC_1778 st046819 58.9 µM -0.013277965830817 0.494149417302238 no 1704 0.494703013679797 2425 671715 SGTC_309 k408-0051 1.48 µM -0.0133757368071515 0.494107582360514 no 1705 0.494664012167142 2434 3640463 SGTC_70 0141-0289 43.283 µM -0.0147977293782811 0.493499137611376 no 1706 0.494096775538778 2498 352408 SGTC_198 3454-2873 16.191 µM -0.0149181843774136 0.493447597783812 no 1707 0.494048726250713 2429 710957 SGTC_3216 9129716 49.47 µM -0.0161787127885194 0.49290825439883 no 1708 0.493545908987941 2442 8056934 SGTC_939 1165-0479 45.3 µM -0.017100907553591 0.492513682280336 no 1709 0.493178057447918 2445 1377347 SGTC_406 estrone 100 µM -0.0177480702381741 0.49223679029525 no 1710 0.492919916085731 2442 5870 A steroid. SGTC_2525 harmine 47.85 µM -0.0178577795860611 0.49218985093636 no 1711 0.492876155323734 2458 5280953 A monoamine oxidase inhibitor SGTC_2798 7813637 45.45 µM -0.0196534291129278 0.49142159462137 no 1712 0.49215992088983 2463 956368 SGTC_145 3737-0113 38.366 µM -0.0212232848978974 0.490749968580586 no 1713 0.491533769900925 2459 6849351 SGTC_1714 st033236 13.627 µM -0.0215302314168276 0.49061865170482 no 1714 0.491411343932617 2455 2916566 SGTC_2168 5727979 200 µM -0.021868106541695 0.490474104228226 no 1715 0.491276582990548 2435 695210 SGTC_907 3448-6986 75.5 µM -0.0226847303723279 0.490124746884514 no 1716 0.490950878050117 2460 590582 SGTC_2881 9058953 51.95 µM -0.0229398352483179 0.49001561278803 no 1717 0.490849132407097 2447 17122249 SGTC_491 tetrandrine 80.3 µM -0.0231137392703675 0.489941216918203 no 1718 0.490779773130781 2453 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1979 st071809 45.3 µM -0.0240663908439936 0.489533680336312 no 1719 0.490399825887286 2529 4976333 SGTC_952 1185-0122 232 µM -0.0243304213559155 0.48942073215012 no 1720 0.490294523788083 2433 678600 SGTC_2964 9083345 53.42 µM -0.0247001968382432 0.489262549322492 no 1721 0.490147049037616 2470 17741579 SGTC_1718 roemerine 11.9335 µM -0.0249270776816094 0.489165494902993 no 1722 0.490056564537471 2454 235224 An aporphine alkaloid with mutagenic activity. SGTC_225 nsc-122657 1.016 µM -0.0254030238521452 0.488961898142172 no 1723 0.489866749601137 2513 275685 SGTC_348 k064-0012 10.7 µM -0.0259778494655595 0.488716007298341 no 1724 0.489637503026929 2442 5066323 SGTC_3202 9113761 49.47 µM -0.0270109197804631 0.488274105801964 no 1725 0.489225512242342 2492 4798415 SGTC_1820 st053765 18.6 µM -0.027399552138717 0.488107869875083 no 1726 0.489070527728637 2479 3690829 SGTC_2334 9017922 200 µM -0.0276718599952998 0.487991392514827 no 1727 0.488961933788284 2482 3163164 SGTC_2396 5342950 42.78 µM -0.0284901839077546 0.487641367653428 no 1728 0.488635598479853 2464 1886677 SGTC_16 erodoxin 22.806 µM -0.0287481500689689 0.487531028747326 no 1729 0.488532727008929 2472 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2721 ifenprodil 61.44 µM -0.0292385939798255 0.487321255637749 no 1730 0.488337150418329 2464 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3320 9137005 35.139 µM -0.0297198537175056 0.487115414200543 no 1731 0.488145238968973 2475 4908713 SGTC_2780 5215298 71.43 µM -0.0299436655145567 0.487019687969547 no 1732 0.488055990701828 2462 2834131 SGTC_3094 9117742 49.47 µM -0.0307442127535297 0.486677293188999 no 1733 0.48773676556711 2460 17149698 SGTC_2620 irigenin 100 µM -0.0310020800839914 0.486567005176781 no 1734 0.487633940402181 2494 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_359 0081-0058 15.9 µM -0.0310434630336283 0.486549306080761 no 1735 0.487617438936403 2492 3494159 SGTC_1989 st071868 50.2 µM -0.031788303958042 0.486230749228305 no 1736 0.487320437006688 2459 16414057 SGTC_3324 9138759 60.749 µM -0.0319533123046439 0.486160178912375 no 1737 0.487254641624948 2532 45595710 SGTC_2845 9003024 42.97 µM -0.0341639347072626 0.485214788679683 no 1738 0.486373212838216 2509 2990173 SGTC_321 4534-3890 65.3 µM -0.0343903070270081 0.485117983359473 no 1739 0.486282956386628 2484 699746 SGTC_3250 9135583 49.47 µM -0.034681620552632 0.484993408027891 no 1740 0.486166808392233 2526 7699353 SGTC_2854 9024559 71.43 µM -0.0346823298111011 0.484993104727214 no 1741 0.486166525609165 2492 3163529 SGTC_1431 4049-0260 9.09 µM -0.034777342315759 0.484952474544299 no 1742 0.48612864395649 2474 3854841 SGTC_1006 4099-6547 255 µM -0.0354486294492811 0.484665416604881 no 1743 0.485861004181979 2511 3146833 SGTC_46 0329-0187a 2.197 µM -0.0362940525856535 0.484303905399008 no 1744 0.485523946083135 2464 46494817 SGTC_815 1582-0027 36.9 µM -0.036359110071008 0.484276086712487 no 1745 0.485498009020762 2506 3128206 SGTC_3296 9122258 64.045 µM -0.0366780562982553 0.484139705897018 no 1746 0.485370852702624 2506 4730474 SGTC_3222 9128301 49.47 µM -0.0383543023540752 0.483422977063321 no 1747 0.484702597794561 2498 4911358 SGTC_3303 9125618 40.5795 µM -0.0388049663028546 0.483230291334326 no 1748 0.484522942640724 2519 22695467 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0390142790812134 0.483140798961236 no 1749 0.484439502110433 2472 688664 SGTC_696 1560-0013 611 µM -0.041685553652069 0.481998762792888 no 1750 0.483374685233375 2527 1650269 SGTC_45 0kpi-0036 14.9 µM -0.0417223561495214 0.481983029821917 no 1751 0.483360015923243 2509 2795021 SGTC_2900 5328528 85.29 µM -0.0418521128239963 0.481927559408514 no 1752 0.483308295675635 2468 795359 SGTC_1163 k060-0048 49.9 µM -0.0419393078781324 0.481890284098987 no 1753 0.483273540397408 2468 6809982 SGTC_857 0438-0306 1.35 µM -0.0424748744448289 0.481661336415127 no 1754 0.483060070479009 2537 4686136 SGTC_2054 5233173 129 µM -0.0426143066487602 0.481601731965676 no 1755 0.483004495397045 2534 6889 SGTC_1468 k284-1086 134 µM -0.0429751875015041 0.481447464607048 no 1756 0.482860656540349 2491 15996457 SGTC_1351 1496-0003 46.5 µM -0.0435521984402804 0.481200812931633 no 1757 0.48263067781556 2502 3891978 SGTC_2835 9006588 71.43 µM -0.0437366606108298 0.481121963421097 no 1758 0.48255715811155 2633 2345538 SGTC_627 1391-0720 175 µM -0.0442585230302736 0.480898894070709 no 1759 0.482349166541498 2522 997839 SGTC_541 4513-1321 94 µM -0.0462759829296082 0.480036590580908 no 1760 0.481545140821279 2503 747515 SGTC_3301 9125354 19.7965 µM -0.0464273614295725 0.479971892041469 no 1761 0.481484814377181 2500 41905162 SGTC_2941 9056145 11.23 µM -0.0470778587281116 0.479693878236009 no 1762 0.481225586971425 2482 2119517 SGTC_1407 3909-7909 12.3 µM -0.049017660372789 0.478864892254416 no 1763 0.480452610957239 2509 4411780 SGTC_2666 tannic acid 100 µM -0.0496295386991528 0.478603421142937 no 1764 0.480208803576067 2502 16134267 A thiamine antagonist. SGTC_1260 0700-1617 7.75 µM -0.0514342385777127 0.47783228121921 no 1765 0.479489751214778 2530 2853078 SGTC_279 1273-0055 2.93 µM -0.0519828359516922 0.477597884410087 no 1766 0.479271184923827 2502 2847562 SGTC_1727 st034309 9.9045 µM -0.0525495266685054 0.477355765075218 no 1767 0.479045416622388 2605 870305 SGTC_1270 0831-1170 17.3 µM -0.0526466316542606 0.477314277681981 no 1768 0.479006730888139 2494 6764716 SGTC_1753 st043925 64 µM -0.0528185106594204 0.477240844240189 no 1769 0.478938256356556 2495 670181 SGTC_1346 1488-2224 62.4 µM -0.053381120141328 0.477000480855689 no 1770 0.478714123853585 2472 3722427 SGTC_2203 7227154 166.4 µM -0.0539461219714432 0.476759103810221 no 1771 0.478489045060655 2510 896304 SGTC_259 usnic acid 108.925 µM -0.0546896781427813 0.476441458747669 no 1772 0.478192846352739 2597 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_913 3487-1245 167 µM -0.0569713143371904 0.475466844622339 no 1773 0.477284022928898 2509 4016153 SGTC_3241 9133421 49.47 µM -0.0576189518124571 0.475190229010289 no 1774 0.477026076694011 2490 17018221 SGTC_1660 st012960 28.1 µM -0.057651050057405 0.4751765196817 no 1775 0.477013292597681 2549 24207266 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0579288050870649 0.475057890282526 no 1776 0.476902669250479 2702 5282309 SGTC_232 clozapine 119 µM -0.0586603115375228 0.474745473889771 no 1777 0.476611335838961 2503 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_286 k060-0067 22.9 µM -0.0589514783449049 0.474621124841437 no 1778 0.476495377761937 2521 5985051 SGTC_501 nsc-95397 161 µM -0.0593384943528702 0.474455845159297 no 1779 0.476341250528524 2566 262093 SGTC_1213 1315-0166 115 µM -0.0606169500290008 0.473909897213886 no 1780 0.475832137088142 2617 768401 SGTC_3121 9125696 49.47 µM -0.060667976000482 0.473888108243356 no 1781 0.475811818066777 2490 1235365 SGTC_2003 4023581 200 µM -0.0606702593105679 0.473887133232365 no 1782 0.475810908832714 2590 16641307 SGTC_3072 9116419 49.47 µM -0.0609718060492727 0.473758369187987 no 1783 0.47569083139022 2553 17170162 SGTC_2246 7293507 91.5585 µM -0.0615699622308759 0.473502957509248 no 1784 0.47545264910509 2594 887656 SGTC_1884 5633444 25 µM -0.0615737277217599 0.473501349685394 no 1785 0.475451149736388 2588 5724239 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0635308808139024 0.472665725529465 no 1786 0.47467188478548 2520 1241132 A phosphatase inhibitor. SGTC_2297 7971671 152.32 µM -0.0635895013250131 0.472640698810842 no 1787 0.474648545776356 2556 909016 SGTC_3015 9080845 49.47 µM -0.0640122454779545 0.472460220835759 no 1788 0.474480238162437 2586 5296973 SGTC_1754 st042065 16.137 µM -0.0641210604007209 0.472413766471799 no 1789 0.474436916288418 2567 1126236 YIL048W NEO1 SGTC_2045 5106652 78.05 µM -0.0641575706229948 0.472398179914683 no 1790 0.474422380746391 2551 673349 SGTC_1901 st060216 58.6 µM -0.0652093656790563 0.471949176960121 no 1791 0.474003652134373 2523 688792 SGTC_2442 5158906 48.48 µM -0.0659975198116937 0.471612743554446 no 1792 0.473689900027455 2617 1893835 SGTC_1634 st006576 41 µM -0.0680689697362167 0.47072861655588 no 1793 0.472865365804595 2543 3915356 SGTC_2650 prasterone 100 µM -0.0680967596750264 0.470716756349347 no 1794 0.472854304887967 2520 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_425 3825-7017 13.1 µM -0.0681732816514471 0.470684098389226 no 1795 0.472823847814983 2740 3397440 SGTC_2644 guaiazulene 100 µM -0.0684491028332541 0.470566385383663 no 1796 0.472714067523543 2560 3515 A coloring agent. SGTC_1324 1418-0026 34.4 µM -0.0686784776960557 0.470468496366578 no 1797 0.472622775028002 2624 1372513 SGTC_173 1273-0061 2.693 µM -0.0689359472447983 0.470358619664782 no 1798 0.472520302401581 2601 2847414 YPL266W DIM1 SGTC_2210 7115885 190.385 µM -0.0693028323074788 0.470202053125536 no 1799 0.472374285652554 2535 2927039 SGTC_3042 9091578 49.47 µM -0.0697646465600181 0.470004982535841 no 1800 0.472190493273291 2510 25236497 SGTC_2720 fluspirilene 36.88 µM -0.0697885933997614 0.469994763870073 no 1801 0.472180963094853 2590 3396 An atypical antipsychotic. SGTC_26 0302-0163 425.158 µM -0.0700094961822202 0.469900500518914 no 1802 0.472093050662434 2547 3100915 SGTC_2453 5731132 22.18 µM -0.0706988123989356 0.469606367257842 no 1803 0.471818733021193 2575 1362040 SGTC_577 r071-0003 38.6 µM -0.0708102558383034 0.469558815567045 no 1804 0.471774384668879 2539 4568517 YMR134W ERG29 SGTC_1846 st056244 14.8 µM -0.0709958914384016 0.469479607860926 no 1805 0.471700512699203 2602 5393182 SGTC_1021 4476-0760 85.3 µM -0.0715941814763561 0.469224335419786 no 1806 0.471462435351668 2539 746768 SGTC_2069 5228469 200 µM -0.0718142146006716 0.469130457051525 no 1807 0.471374880207067 2615 2835210 SGTC_2012 4023501 200 µM -0.0720054967513077 0.469048846841957 no 1808 0.471298766716901 2573 3477460 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.072230177769793 0.468952988722387 no 1809 0.471209364750795 2529 165521 SGTC_2269 7935389 174.42 µM -0.0735340488632013 0.468396739643208 no 1810 0.470690575165329 2524 97605 SGTC_470 aa-861 153 µM -0.0736186744243969 0.468360639352181 no 1811 0.470656905708906 2542 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1733 st037357 54.9 µM -0.0747350085901259 0.467884448502113 no 1812 0.470212776361486 2535 1272339 YGL099W LSG1 SGTC_2580 diallyl disulphide 81.36 µM -0.0749119115366863 0.467808991817132 no 1813 0.470142399576639 2579 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3123 9126162 49.47 µM -0.0757752656978782 0.467440750929306 no 1814 0.469798947324373 2545 25239884 SGTC_2496 diffractaic acid 79.83 µM -0.0759323945414708 0.467373734763718 no 1815 0.469736442065659 2549 94870 An apoptosis inducer which activates caspases. SGTC_892 0929-0076 29 µM -0.0762329197292915 0.467245561983337 no 1816 0.469616896362932 2545 5751038 SGTC_1800 st050079 29.0735 µM -0.0772827624639225 0.466797835032548 no 1817 0.469199301726184 2561 3645560 SGTC_1332 1480-0653 17.5 µM -0.0773777357335738 0.46675733379884 no 1818 0.469161525991284 2517 5749438 SGTC_2712 st079126 47.7 µM -0.0783888216380602 0.466326178883249 no 1819 0.468759382605074 2537 3152970 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0786185861364095 0.466228206456268 no 1820 0.468668001848732 2656 165506 SGTC_618 k072-0232 33.2 µM -0.0789117463052967 0.466103204854437 no 1821 0.468551410089174 2592 5872756 YGL099W LSG1 SGTC_148 3253-0744 288.01 µM -0.0799511443212051 0.465660039285352 no 1822 0.46813805634966 2532 6893655 SGTC_2675 theaflavin digallate 100 µM -0.0807726228983727 0.465309817588902 no 1823 0.46781139033661 2574 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2145 5634607 200 µM -0.0808676271502689 0.465269316069417 no 1824 0.467773612705136 2536 308662 SGTC_3331 9141060 1.957 µM -0.08177374456068 0.464883044845557 no 1825 0.467413317469065 2563 4906567 YPR165W RHO1 SGTC_3330 9141424 71.43 µM -0.0825239262623623 0.464563272895943 no 1826 0.467115046407981 2623 27261020 SGTC_2267 7931562 200 µM -0.0826641317745346 0.46450351152044 no 1827 0.467059302960499 2524 934880 SGTC_1247 0448-0043 5.84 µM -0.0828253766602388 0.464434783285746 no 1828 0.466995195396687 2623 3089013 YGL099W LSG1 SGTC_1094 duloxetine 25.4 µM -0.0830801150692768 0.464326206990298 no 1829 0.466893918526352 2534 60834 A selective serotonin reuptake inhibitor. SGTC_2057 5236571 38.335 µM -0.0831081882061889 0.46431424163392 no 1830 0.466882757562889 2573 54684039 YBR257W POP4 SGTC_820 1582-0060 59.9 µM -0.0831588365797724 0.464292654322544 no 1831 0.466862621487627 2585 3848840 SGTC_1797 st048695 56.8 µM -0.0832817082003325 0.464240284510556 no 1832 0.466813772251838 2546 592262 YIL048W NEO1 SGTC_2405 ticlatone 3.52 µM -0.0845590067971703 0.463695916675552 no 1833 0.466305995065595 2517 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_409 arachidonic acid 100 µM -0.0847386799127793 0.463619347789804 no 1834 0.466234572209775 2552 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2291 7917025 104.35 µM -0.0847875281386548 0.463598531028363 no 1835 0.466215154468734 2574 2964612 SGTC_2027 5150920 200 µM -0.0854122390653959 0.46333231812332 no 1836 0.465966831676586 2623 786715 SGTC_838 0109-0203 71.4 µM -0.0857922958545801 0.463170369605889 no 1837 0.465815765458131 2560 759422 SGTC_211 3455-0679 143.504 µM -0.0859241768724712 0.463114174336366 no 1838 0.465763346108853 2598 748649 SGTC_1736 st036774 51 µM -0.0867805147063324 0.462749301756326 no 1839 0.465422988098019 2670 1272247 SGTC_2819 7996655 46.38 µM -0.0871212598350888 0.462604124117348 no 1840 0.46528756336523 2610 6456960 SGTC_1427 4048-4900 550 nM -0.0873335977927178 0.462513658068818 no 1841 0.465203174429657 2639 24132586 SGTC_755 1995-0008 37.3 µM -0.0873834956765431 0.462492399483106 no 1842 0.465183343867273 2553 689533 SGTC_2704 st078022 71.1 µM -0.0878452727892675 0.462295668208591 no 1843 0.464999827170765 2626 54697681 SGTC_2098 5376439 882.5 nM -0.0884025142024654 0.462058278486459 no 1844 0.464778381538561 2662 2844116 SGTC_3000 9075062 71.4286 µM -0.0884043745456572 0.462057485986556 no 1845 0.464777642263437 2593 17057871 SGTC_95 0471-0001 561.058 µM -0.0886281963069714 0.461962139773986 no 1846 0.464688699422653 2582 4015405 SGTC_2 0422-0095 29 µM -0.0900427894530844 0.461359585623827 no 1847 0.464126605921383 2491 6790840 SGTC_1019 4262-0212 3.4 µM -0.0910102955738772 0.460947521773635 no 1848 0.463742205162249 2565 4677213 SGTC_1035 k081-0041 55.2 µM -0.0916379968630411 0.460680204249848 no 1849 0.463492830657971 2546 731709 SGTC_1257 0669-0121 16 µM -0.0942699304468857 0.459559544335028 no 1850 0.462447367772418 2666 4307855 SGTC_2341 7987486 176.74 µM -0.0943762805401442 0.45951426786132 no 1851 0.462405128540276 2599 1258686 SGTC_1777 st045864 34.765 µM -0.0945669180062082 0.459433109000509 no 1852 0.462329413822441 2584 4691462 SGTC_699 0375-0592 111 µM -0.0953561133987523 0.459097147950389 no 1853 0.462015986805438 2566 762578 SGTC_2432 5630864 12.22 µM -0.0954369016436281 0.459062757980134 no 1854 0.461983903279414 2681 5714970 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0954896946394943 0.459040285203423 no 1855 0.461962937671561 2666 5393153 SGTC_1504 k297-0033 30 µM -0.0957492496917425 0.458929800430498 no 1856 0.461859862478688 2545 4388117 SGTC_2896 9052656 71.43 µM -0.0958459097112721 0.458888655979953 no 1857 0.461821477248821 2580 6469436 SGTC_322 k048-0136 19.3 µM -0.0962413605036783 0.458720332386905 no 1858 0.461664441162017 2668 6823282 SGTC_2131 toluylene red 5.2905 µM -0.096538615728587 0.458593810599008 no 1859 0.461546403108354 2603 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2178 5812956 200 µM -0.0975139433052829 0.458178708017135 no 1860 0.46115913092238 2546 5403383 SGTC_2352 9027995 87.8 µM -0.0980708094027302 0.457941724423508 no 1861 0.460938033243217 2635 2997347 SGTC_879 0831-1030 162 µM -0.0995324921516164 0.457319752455124 no 1862 0.460357745485628 2596 1549252 SGTC_2195 6536160 144.242 µM -0.0997217229028751 0.457239239019306 no 1863 0.460282627061131 2585 3834386 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.101099300670694 0.456653163711411 no 1864 0.459735816593402 2572 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1452 4194-0072 190 µM -0.101658587032254 0.456415248317301 no 1865 0.459513837273162 2719 1343545 SGTC_97 0535-0701 19.132 µM -0.103259575410317 0.455734288910465 no 1866 0.458878479105621 2629 2832013 YGL099W LSG1 SGTC_229 benomyl 22.8748 µM -0.104605671174369 0.455161845263694 no 1867 0.458344357226039 2662 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_686 1319-0111 510 µM -0.105084165794625 0.454958381953722 no 1868 0.458154511799449 2656 4562600 SGTC_116 0155-0182 31.788 µM -0.106054012165052 0.454546024582921 no 1869 0.457769749134426 2600 771486 SGTC_3080 9117754 49.47 µM -0.107444478335802 0.453954914475146 no 1870 0.457218185050638 2648 9550191 SGTC_2208 7283366 200 µM -0.108015530333267 0.453712180316874 no 1871 0.456991686432081 2606 898663 SGTC_2123 5259487 200 µM -0.108169478563997 0.453646745283203 no 1872 0.456930627722536 2665 2173474 SGTC_916 4466-0038 42 nM -0.109616973090344 0.4530315557369 no 1873 0.456356574599316 2627 5722064 YGL116W CDC20 SGTC_625 k213-0058 121 µM -0.109836791533809 0.452938142055875 no 1874 0.456269406065146 2646 3655420 SGTC_1568 digitonin 820 nM -0.110118172181666 0.4528185708039 no 1875 0.456157828242137 2624 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2512 diallyl trisulfide 49.23 µM -0.110511682666231 0.452651357734861 no 1876 0.456001792596206 2576 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_231 b-estradiol 524 µM -0.111166403176642 0.452373168201058 no 1877 0.455742196422548 2604 450 A steroid. SGTC_3317 9138495 8.753 µM -0.11124780241593 0.452338583446082 no 1878 0.455709923005677 2604 17020139 SGTC_1486 3970-0793 4.53 µM -0.11166769670158 0.452160185305281 no 1879 0.455543446694625 2689 2844330 SGTC_1197 1601-0112 267 µM -0.112297155500571 0.451892768762907 no 1880 0.455293898560336 2593 7350313 SGTC_2395 5646831 180.19 µM -0.113944319740871 0.451193098249077 no 1881 0.454640966128386 2720 6808628 SGTC_930 2810-3379 265 µM -0.113955171456087 0.451188489236285 no 1882 0.454636664935728 2760 1015764 SGTC_1314 1222-0010 41.1 µM -0.114021542264982 0.451160299927327 no 1883 0.454610358276003 2654 3526027 SGTC_3231 9132313 49.47 µM -0.114484169839311 0.45096381750952 no 1884 0.454426997263447 2655 4905967 SGTC_682 0kpi-0099 17 µM -0.11693439963857 0.449923382616584 no 1885 0.453456019084319 2701 1714895 YML126C ERG13 SGTC_2231 micatex 6.853 µM -0.117387838858425 0.449730877386815 no 1886 0.453276360314158 2641 20737 An antifungal of unknown mechanism. SGTC_2338 7999974 200 µM -0.117793598455832 0.449558624316927 no 1887 0.453115600963385 2715 315925 SGTC_465 cgp-37157 41 µM -0.117927707638493 0.449501694373094 no 1888 0.45306246945325 2605 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_836 0330-0104 1.35 µM -0.11819729499892 0.44938725648696 no 1889 0.452955666606413 2627 46494820 SGTC_813 k007-0158 173 µM -0.118719634224964 0.449165539248913 no 1890 0.452748740348712 2688 6523916 SGTC_2502 avocadyne acetate 18.59 µM -0.120094903723888 0.448581854936886 no 1891 0.452203984706457 2584 3952079 SGTC_2153 5569715 200 µM -0.120924553528148 0.448229793265937 no 1892 0.451875396987732 2612 2054701 SGTC_2511 berberine 10.47 µM -0.1216503203191 0.447921847747143 no 1893 0.451587979775122 2657 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3227 9130768 49.47 µM -0.12259939255875 0.447519200286555 no 1894 0.451212167741759 2637 17720899 SGTC_2245 6637752 200 µM -0.124706864520576 0.446625291354701 no 1895 0.450377811364244 2778 681890 SGTC_586 0957-0265 8.15 µM -0.126451423180014 0.445885521276823 no 1896 0.449687299491776 2618 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1384 3089-0840 101 µM -0.126714177729595 0.445774117976315 no 1897 0.449583312045171 2656 1069836 SGTC_2400 5203494 178.7 µM -0.128565039235873 0.4449895070844 no 1898 0.448850915657722 2608 6777674 SGTC_1499 4480-0877 67.3 µM -0.128956655701739 0.444823521883039 no 1899 0.44869597305551 2632 2861909 SGTC_2116 5511452 16.8835 µM -0.129118913266729 0.444754752442699 no 1900 0.448631778328674 2749 870744 SGTC_664 1222-0054 14.9 µM -0.12968249917312 0.444515901396479 no 1901 0.448408814633632 2668 6813991 SGTC_3130 9127414 49.47 µM -0.130383518665438 0.444218833306851 no 1902 0.448131502738473 2617 1494646 SGTC_25 0118-0223 35.662 µM -0.131781430841301 0.443626539635221 no 1903 0.447578587243022 2691 5333628 SGTC_2541 muurolladie-3-one 83.07 µM -0.13181974902988 0.443610306032776 no 1904 0.447563432698581 2807 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_314 1671-0008 2.74 µM -0.132342152724219 0.4433889977697 no 1905 0.447356833760515 2634 3913060 SGTC_515 4092-1064 102 µM -0.132787640544744 0.443200287675463 no 1906 0.447180664605693 2753 717353 SGTC_3126 9127922 49.47 µM -0.133113373280374 0.443062314376783 no 1907 0.447051859460558 2886 45595682 SGTC_3310 9130229 44.1445 µM -0.133453510519119 0.442918247012721 no 1908 0.446917364274951 2782 7761258 SGTC_2159 5658611 73.75 µM -0.133978415676049 0.442695934797837 no 1909 0.446709821166653 2628 793844 SGTC_1054 3429-0080 167 µM -0.134717671016011 0.442382869816313 no 1910 0.446417550554147 2730 1162877 SGTC_1335 1486-0900 202 µM -0.135634079826418 0.441994832617875 no 1911 0.446055281297412 2629 X1335 SGTC_1495 4469-0029 237 µM -0.135758471682904 0.441942165355029 no 1912 0.446006110915804 2640 793680 SGTC_1640 st009078 66.4 µM -0.13707187454901 0.441386136018942 no 1913 0.445486991729694 2754 690618 SGTC_1620 st003704 16.5 µM -0.13745557367313 0.441223718678425 no 1914 0.445335353212774 2666 2834414 SGTC_1044 1222-0021 1.78 µM -0.137722867165801 0.441110580923228 no 1915 0.445229723115232 2782 4306703 SGTC_1932 st074806 40.9 µM -0.137852956443361 0.441055519559354 no 1916 0.445178315327309 2886 17251235 SGTC_3356 9151811 4.48 µM -0.137934263126481 0.441021106411038 no 1917 0.445146185578373 2646 1859254 YPR165W RHO1 SGTC_3180 9109287 49.47 µM -0.139101541991271 0.440527103488841 no 1918 0.444684954870432 2768 18891271 SGTC_1052 3253-3998 198 µM -0.139488548103714 0.44036333940941 no 1919 0.444532052381157 2641 5450317 SGTC_917 harmaline 728.087 nM -0.14131634493775 0.439590033957007 no 1920 0.443810018899313 2756 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_370 0180-0345 38.7 µM -0.141596694315755 0.439471443873332 no 1921 0.443699289088845 2624 3989527 SGTC_616 4092-0450 108 µM -0.14160270605144 0.439468900919334 no 1922 0.443696914677064 2711 787165 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.142198110490608 0.439217058242133 no 1923 0.443461762117366 2907 6710655 SGTC_1657 st012939 43.4 µM -0.143743817693144 0.43856337396479 no 1924 0.442851384480856 2779 24207257 SGTC_503 tyrphostin 8 294 µM -0.143982126800356 0.438462607182044 no 1925 0.442757291656527 2682 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_987 1497-1013 404 µM -0.145031667345393 0.438018866312032 no 1926 0.442342934594226 2659 1676435 SGTC_1301 naphtanilide LB 4.81 µM -0.145077587672582 0.437999453186139 no 1927 0.442324806753442 2757 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1143 3454-2408 5.08 µM -0.145176370417764 0.437957692624771 no 1928 0.442285810971226 2637 X1143 SGTC_2513 baicalein 25.65 µM -0.146592959984775 0.437358903375487 no 1929 0.44172665538406 2709 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2523 spermine 47.74 µM -0.147128027322737 0.437132768855399 no 1930 0.441515483998598 2737 1103 A DNA binding polyamine. SGTC_1673 st016611 27.3 µM -0.14804724395185 0.436744330018453 no 1931 0.441152741869201 2881 5226799 SGTC_904 1141-0088 396 µM -0.148518364852791 0.436545269271092 no 1932 0.440966846810551 2713 1378119 SGTC_2313 7726885 200 µM -0.149824928003581 0.435993296823643 no 1933 0.440451370820236 2771 726423 SGTC_2219 9098279 200 µM -0.149832976999347 0.435989896819132 no 1934 0.440448195576352 2674 902349 SGTC_3044 9093193 49.47 µM -0.150458383855463 0.435725730999765 no 1935 0.440201490895819 2785 25236277 SGTC_3105 9121040 49.47 µM -0.150905687922104 0.435536811661414 no 1936 0.440025056780459 2633 41448907 SGTC_31 0508-1974 57.237 µM -0.155221517286981 0.433714778611648 no 1937 0.438323342766223 2721 6810525 SGTC_3001 9076041 71.4286 µM -0.155258377559523 0.433699223152687 no 1938 0.438308813774357 2693 16004211 SGTC_3055 9094636 49.47 µM -0.155430314506183 0.433626665140722 no 1939 0.438241043521307 2837 25236176 SGTC_2075 5212009 200 µM -0.156035049080838 0.433371482752347 no 1940 0.438002697197023 2790 780898 SGTC_611 3453-1652 23.7 µM -0.156672619862466 0.433102474411189 no 1941 0.437751433370105 2728 1560575 SGTC_1369 1866-0067 208 µM -0.15750479518507 0.432751403803344 no 1942 0.437423514526236 2724 3531355 SGTC_2198 6589944 200 µM -0.157753083350498 0.432646668502696 no 1943 0.437325684841878 2718 5290268 SGTC_36 0335-0881 14.2 µM -0.157814611751914 0.432620714732277 no 1944 0.437301442216204 2669 23828853 SGTC_2655 perillic acid 100 µM -0.157940087136571 0.432567787891743 no 1945 0.437252004756098 2675 5702197 An apoptosis inducer. SGTC_2715 st079500 56.4 µM -0.161316962453271 0.431143843716926 no 1946 0.43592188206064 2676 28246688 SGTC_2685 mycophenolic acid 18.85 µM -0.161797569477496 0.430941255997003 no 1947 0.43573263355027 2747 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_697 0508-1955 564 µM -0.162138260206625 0.430797657450042 no 1948 0.435598488755786 2762 6243113 SGTC_1612 st002233 45.4 µM -0.162301625890004 0.430728803303193 no 1949 0.435534167190848 2684 1035021 SGTC_197 4544-0043 41.561 µM -0.162628556709234 0.430591017271293 no 1950 0.435405450654225 2703 896523 SGTC_3145 9085516 49.47 µM -0.163006124402038 0.430431900683135 no 1951 0.43525680629692 2762 25236195 SGTC_2303 7774051 200 µM -0.16311673884364 0.430385287094069 no 1952 0.435213260307543 2829 2953184 SGTC_2072 5231554 129 µM -0.1631873501292 0.430355531582096 no 1953 0.435185462916869 2785 789545 SGTC_1594 piperine 70.1 µM -0.163707392429506 0.430136398565895 no 1954 0.434980748874667 2697 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2818 7996756 12.99 µM -0.164697371625593 0.4297193052383 no 1955 0.434591092934605 2680 2241621 SGTC_2266 7929956 200 µM -0.166842623262558 0.42881574774423 no 1956 0.433746940091408 2676 2967153 SGTC_1814 st052110 31.539 µM -0.168016960090314 0.428321287033391 no 1957 0.433284968264406 2784 674163 SGTC_866 0495-0101 262 µM -0.168198117035419 0.428245019944282 no 1958 0.43321371111556 2715 635694 SGTC_1810 st050138 53 µM -0.168523685647464 0.428107962269554 no 1959 0.433085655842041 2706 3444541 SGTC_1089 terbinafine 2.25 µM -0.168637980232793 0.428059848660943 no 1960 0.433040702238976 2822 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2950 9072895 21.46 µM -0.168796890680031 0.427992955274066 no 1961 0.432978202055154 2802 17332245 SGTC_513 4245-1575 41.7 µM -0.16893532840566 0.427934681570324 no 1962 0.432923755249901 2832 719745 SGTC_1001 4048-4355 44.4 µM -0.169360217653847 0.427755839346698 no 1963 0.432756656573029 2709 21824233 SGTC_2180 6301957 200 µM -0.17066483494463 0.427206799367998 no 1964 0.432243657375265 2740 845462 SGTC_2877 9040724 71.43 µM -0.170711502929269 0.427187162045531 no 1965 0.432225308787381 2898 6463895 SGTC_2104 5389443 200 µM -0.171780910892849 0.426737217665973 no 1966 0.431804886665726 2872 2244536 SGTC_2755 lomerizine 42.69 µM -0.172383733869191 0.426483626954852 no 1967 0.431567929622778 2742 3949 A calcium channel blocker. SGTC_153 4077-0274 519.67 µM -0.173719864642761 0.425921662701779 no 1968 0.431042812585582 2901 3121976 SGTC_742 0kpi-0133 140 µM -0.174153341163647 0.425739378743197 no 1969 0.43087247672793 2877 2728852 SGTC_3235 9132602 49.47 µM -0.174449805604039 0.425614719738249 no 1970 0.430755987567632 2806 4912240 SGTC_2723 salbutamol 83.58 µM -0.175219240257769 0.425291218324458 no 1971 0.430453683330827 2817 9884233 β2-adrenoceptor agonist SGTC_732 3970-1727 52.7 µM -0.176000173495449 0.424962933868134 no 1972 0.430146903072415 2836 1275699 SGTC_1937 st074714 47.2 µM -0.176274175212849 0.424847762838955 no 1973 0.430039274765782 2697 17250970 SGTC_2227 7312221 64.1025 µM -0.176428816676888 0.424782765287155 no 1974 0.429978533649164 2733 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_572 0960-0087 17.7 µM -0.177055859900283 0.424519232922124 no 1975 0.429732256383128 2730 6796365 SGTC_2082 5219693 150 µM -0.178807215663444 0.423783355995654 no 1976 0.429044539658455 2719 2834649 SGTC_1216 1165-0504 9.65 µM -0.180010037588458 0.423278113340896 no 1977 0.428572344033174 2797 6304004 SGTC_155 k072-0202 43.6 µM -0.18014030620065 0.423223401857714 no 1978 0.4285212101937 2686 5857737 SGTC_1999 st074831 12.5 µM -0.180803385058277 0.422944938496007 no 1979 0.428260953005034 2763 17112523 SGTC_385 1494-0393 12.4 µM -0.181583857077379 0.422617224604576 no 1980 0.427954659206444 2769 3090647 SGTC_1210 3013-0140 750 nM -0.182599722344081 0.42219075123818 no 1981 0.42755605110867 2893 905973 SGTC_2922 7999257 32.47 µM -0.183166203849072 0.421952974563729 no 1982 0.427333805570857 2713 2988377 SGTC_1043 0916-0009 19.3 µM -0.183168334686236 0.421952080213291 no 1983 0.427332969631093 2818 3101130 SGTC_2804 7954240 19.48 µM -0.183511412218043 0.421808089694582 no 1984 0.427198382585433 2880 828705 SGTC_2611 pyromycin 23.93 µM -0.184151217948367 0.421539589529204 no 1985 0.426947413677667 2768 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3245 9134821 49.47 µM -0.185442350879457 0.420997865310343 no 1986 0.426441046614778 2732 17014901 SGTC_3177 9107506 49.47 µM -0.187024338584949 0.420334310313289 no 1987 0.425820775097302 2834 8897194 SGTC_2085 5307070 144.047 µM -0.188858385689141 0.419565313976677 no 1988 0.425101904985564 2721 2840351 SGTC_3068 9116768 49.47 µM -0.189497248561652 0.419297517569632 no 1989 0.424851555680857 2836 41904888 SGTC_2789 5281112 71.43 µM -0.190754639597832 0.418770557884135 no 1990 0.424358914188703 2801 765948 SGTC_2994 9053520 71.4286 µM -0.19084992120481 0.418730632267607 no 1991 0.424321587988362 2878 4647384 SGTC_1685 st024049 53.0905 µM -0.191012132196339 0.418662663322165 no 1992 0.424258044022511 2828 1941139 SGTC_1899 st063254 59.6 µM -0.191075257038545 0.418636213681041 no 1993 0.424233316249931 2719 3093813 SGTC_1916 st067606 49.2 µM -0.191501551555629 0.418457603670164 no 1994 0.424066332534589 2856 19590279 SGTC_1067 clotrimazole 1.36 µM -0.192620333513888 0.417988933474732 no 1995 0.423628159648776 2750 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.192637776933021 0.417981627152771 no 1996 0.423621328649698 2763 6708514 SGTC_630 4356-0227 183 µM -0.19349300714141 0.417623441593098 no 1997 0.423286441035033 2759 779312 SGTC_861 0443-0273 110 µM -0.195066410815839 0.416964650975557 no 1998 0.422670478857146 2836 6149169 SGTC_1404 3909-7820 48.3 µM -0.195271643085902 0.416878736522043 no 1999 0.422590147635894 2815 23741373 SGTC_427 1354-0053 47.3 µM -0.195310594807301 0.416862430977616 no 2000 0.422574901667162 2980 6813657 SGTC_1569 carminic acid 40.6 µM -0.197474882562314 0.415956665983392 no 2001 0.421727967615923 2863 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2692 st077426 47.7 µM -0.19846467138885 0.415542582937522 no 2002 0.421340761548559 2891 25238571 SGTC_2214 7179297 48.276 µM -0.199085663206236 0.415282835784533 no 2003 0.421097867927728 2749 769744 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.199841670804513 0.414966664493463 no 2004 0.420802205016058 2779 689007 SGTC_1283 0922-0125 16.4 µM -0.199957111679307 0.414918390599856 no 2005 0.420757061797285 2879 3360884 SGTC_2903 5923464 63.88 µM -0.200287185782923 0.414780370650848 no 2006 0.420627991885304 2851 2876576 SGTC_1424 4048-1941 275 µM -0.20069455794129 0.414610043150452 no 2007 0.420468707637694 2871 X1424 SGTC_2325 6158266 200 µM -0.201096905008625 0.414441832462553 no 2008 0.420311401004131 2844 3623240 SGTC_2078 5212016 200 µM -0.20183372527389 0.414133828057463 no 2009 0.420023357565459 2729 1899708 SGTC_2281 7943571 200 µM -0.203147091863313 0.41358494775984 no 2010 0.419510032525704 2916 1244024 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.2036895865884 0.413358278339464 no 2011 0.419298040150777 2900 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1927 st060202 13.8 µM -0.204169363563046 0.413157838200877 no 2012 0.419110575705551 2730 688887 SGTC_2829 7992743 58.44 µM -0.204513021777362 0.413014279359545 no 2013 0.41897630856508 2975 16462845 SGTC_3189 9110682 49.47 µM -0.205645407908668 0.412541321886082 no 2014 0.418533952568765 2875 17122418 SGTC_1646 st011709 75.6 µM -0.206578870955872 0.412151542950697 no 2015 0.418169381429446 2827 5757843 SGTC_1562 morin hydrate 59.1 µM -0.20801875331887 0.411550472448966 no 2016 0.417607162300961 2949 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1694 st024011 44.9 µM -0.208042437158728 0.411540587498961 no 2017 0.417597916069531 2787 2787533 SGTC_985 1493-0307 8.71 µM -0.208669724298052 0.411278796439397 no 2018 0.417353038170214 2902 3278274 SGTC_1088 bifonazole 369 nM -0.208941620233015 0.411165336068537 no 2019 0.417246906450604 2757 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3270 9137563 49.47 µM -0.209504159225271 0.410930615876818 no 2020 0.417027344419016 2892 17015724 SGTC_1741 st038134 10.228 µM -0.209782683063014 0.410814413208165 no 2021 0.416918644621568 2973 1272587 SGTC_3220 9131269 49.47 µM -0.210556570086864 0.410491581646272 no 2022 0.416616652265538 2726 17722206 SGTC_1440 4100-1550 40 µM -0.210608824505005 0.4104697855888 no 2023 0.416596262901882 2784 742806 SGTC_3186 9110464 49.47 µM -0.210778113120527 0.410399174810321 no 2024 0.416530209030693 2895 17018021 SGTC_1185 1319-0113 81.3 µM -0.212244567606255 0.409787634126303 no 2025 0.415958119380846 2882 4672763 SGTC_2697 mebhydrolin 72.4 µM -0.213022001025819 0.409463517817492 no 2026 0.415654901085641 2919 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2024 5144227 134 µM -0.214443487649617 0.408871052289234 no 2027 0.415100616047022 2941 3475211 SGTC_523 1934-0222 13.7 µM -0.214703238361259 0.408762812491945 no 2028 0.414999348806348 2800 1361595 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.214807319668714 0.40871944309188 no 2029 0.414958772920417 2762 364106 SGTC_556 4058-0063 51.5 µM -0.21566756020634 0.408361034287985 no 2030 0.414623444669801 2813 6615692 SGTC_1153 4055-0057 267 µM -0.216160110768397 0.408155853546146 no 2031 0.414431472735774 2784 882706 SGTC_2320 7373003 200 µM -0.216784355886948 0.407895849268523 no 2032 0.414188202125355 2835 5415828 SGTC_792 4534-1957 155 µM -0.218213501900119 0.407300748677827 no 2033 0.413631382784048 2841 1717904 SGTC_2388 9080168 200 µM -0.218639349607174 0.407123465745949 no 2034 0.413465498875924 2780 15943073 SGTC_2009 4012297 12.05 µM -0.219468642711791 0.406778280729763 no 2035 0.413142501961724 2913 45595307 SGTC_2565 isoliquiritigenin 100 µM -0.220872832784924 0.40619396580297 no 2036 0.412595725658408 2935 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1129 3453-1384 223 µM -0.222073293738042 0.405694592676124 no 2037 0.412128413652976 3017 1084452 SGTC_2841 9004761 38.96 µM -0.223547996725171 0.405081349207644 no 2038 0.411554516058995 2818 2991039 SGTC_1867 st057372 64 µM -0.224020585314019 0.404884876239626 no 2039 0.41137064275182 2804 688837 SGTC_1758 st042942 75.2445 µM -0.224270027428501 0.404781183372612 no 2040 0.411273598431241 2785 669317 SGTC_2309 7664088 163.95 µM -0.224393801866802 0.404729732929279 no 2041 0.411225446563604 2940 704922 SGTC_2163 5671233 125 µM -0.22500343352876 0.404476345858351 no 2042 0.410988301589399 2983 701023 SGTC_2959 9079155 11 µM -0.225450848892818 0.40429040778994 no 2043 0.41081427898249 2974 16189457 SGTC_2884 9058502 51.95 µM -0.225765882552431 0.404159498229587 no 2044 0.410691756887062 2911 6471554 SGTC_1165 k072-0275 30.3 µM -0.22597386200554 0.404073080015171 no 2045 0.410610874817926 2840 6153523 YGL055W OLE1 SGTC_812 4251-0442 148 µM -0.227326107135654 0.403511318618922 no 2046 0.410085086951202 2825 5723007 SGTC_657 3534-0529 86.7 µM -0.227872723493207 0.40328429493038 no 2047 0.409872594193344 2974 1049549 SGTC_635 k038-0028 24.7 µM -0.228292617614055 0.403109924342322 no 2048 0.409709381667056 2852 4035102 SGTC_1037 k284-1091 78.7 µM -0.228533120910119 0.403010058551223 no 2049 0.40961590526317 2789 3334711 SGTC_2409 alverine citrate 63.97 µM -0.228730198866274 0.402928229270034 no 2050 0.409539310813592 3072 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.229532975321502 0.402594950212858 no 2051 0.409227347034809 2820 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3 0833-0587 95.581 µM -0.229971431540106 0.402412951480974 no 2052 0.409056984557767 2863 5382644 SGTC_511 blebbistatin 171 µM -0.230322280927586 0.402267332688455 no 2053 0.408920674147947 2956 3476986 A myosin inhibitor. SGTC_1284 0929-0043 16 µM -0.230495234012974 0.402195554113869 no 2054 0.408853483253245 2867 1239883 SGTC_1707 st032323 6.317 µM -0.230666567270743 0.402124451048053 no 2055 0.408786924289643 2831 3132057 YMR211W DML1 SGTC_2345 9052315 157.45 µM -0.231298277658071 0.401862320110303 no 2056 0.40854154232091 2903 6469265 SGTC_3218 9131285 49.47 µM -0.232554083088214 0.401341349461593 no 2057 0.408053843058285 2964 17156417 SGTC_1183 1254-0324 198 µM -0.232938449673239 0.40118193005853 no 2058 0.407904600514309 2956 5799357 SGTC_2943 9068529 45.32 µM -0.233471796922164 0.400960746877588 no 2059 0.407697533630394 2791 3270634 SGTC_1805 st050013 60.3 µM -0.235121969160661 0.400276609169142 no 2060 0.407057033840517 2879 4037144 SGTC_537 1334-0398 209 µM -0.235608237628984 0.400075067502015 no 2061 0.406868340347818 2983 5846986 SGTC_1515 3460-0031 42.1 µM -0.236322093514475 0.399779246847955 no 2062 0.406591372128478 2844 2876596 SGTC_1771 st048882 4.1505 µM -0.236539557213272 0.399689141685409 no 2063 0.406507007887067 2805 4580403 SGTC_1641 st009299 47.1 µM -0.236653185815201 0.399642062279965 no 2064 0.406462927815124 2837 4046054 SGTC_1762 st045503 25.4615 µM -0.238507715627626 0.398873887090577 no 2065 0.405743665899651 2907 4645554 SGTC_149 3970-0822 46.1 µM -0.238548147450712 0.398857143948931 no 2066 0.405727988332375 2824 3114250 YBL034C STU1 SGTC_736 0958-0254 92.6 µM -0.238677911190787 0.398803409002607 no 2067 0.405677673053285 2947 6812352 SGTC_898 1000-0849 28.3 µM -0.239202171968901 0.398586333035432 no 2068 0.40547440927968 2839 6751807 SGTC_1408 3909-7976 48.8 µM -0.239322687295266 0.398536436765506 no 2069 0.405427687279686 2865 24152374 SGTC_1796 st049173 110.4 µM -0.239699749010131 0.398380334780673 no 2070 0.405281514766204 2871 94134 SGTC_1769 st044406 64.4 µM -0.242218627911594 0.397337947641568 no 2071 0.404305380881776 2826 670903 SGTC_49 0717-0965 32.132 µM -0.243297064895012 0.396891881878075 no 2072 0.403887638985211 3121 5889349 YGL099W LSG1 SGTC_3298 9116858 71.43 µM -0.243635163101636 0.396752064606634 no 2073 0.403756696262888 2980 2506942 SGTC_1623 st003709 20.3 µM -0.245882458232855 0.395823055382173 no 2074 0.402886611670642 2829 16192618 SGTC_626 0214-0009 33 µM -0.247436625029592 0.395180924079958 no 2075 0.40228516626566 2953 3437874 SGTC_834 0312-0008 75.7 µM -0.248141227618396 0.394889898783945 no 2076 0.402012568939264 2835 6385573 YIL048W NEO1 SGTC_2221 6807166 181.081 µM -0.248642262617584 0.394682989621834 no 2077 0.401818757023045 2910 674925 SGTC_488 nitrendipine 139 µM -0.248936431048581 0.394561522635718 no 2078 0.401704977121762 2832 4507 Dihydropyridine L-type calcium channel blocker. SGTC_143 4032-1194 15.74 µM -0.249786114616201 0.39421073191133 no 2079 0.401376379186161 2769 1806963 SGTC_1785 bathophenanthroline 24 µM -0.25172852674862 0.393409132324999 no 2080 0.400625452857365 2867 72812 An iron chelator. SGTC_3273 9137859 49.47 µM -0.252976726530072 0.392894260180301 no 2081 0.40014309894659 2879 2377234 SGTC_2421 5690543 90.72 µM -0.253190118248631 0.392806256577585 no 2082 0.400060651144871 2951 3397993 SGTC_1997 st073024 93.8 µM -0.254134003601545 0.39241706024037 no 2083 0.399696017213679 2982 686268 SGTC_397 arbidol 50 µM -0.254201216045198 0.392389350340611 no 2084 0.399670055593942 2999 131410 A RNA synthesis inhibitor. SGTC_2048 5246248 200 µM -0.254350904960287 0.392327639549904 no 2085 0.39961223803314 2964 677046 SGTC_2790 5423970 71.43 µM -0.254540629308798 0.392249427631935 no 2086 0.399538959891333 3037 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2460 5552655 174.22 µM -0.254977524532643 0.392069338611108 no 2087 0.399370229222234 2971 5401989 SGTC_2379 9035213 200 µM -0.2588499469053 0.390474133649737 no 2088 0.397875509374101 3012 646551 SGTC_3257 9139206 32.98 µM -0.260269239289864 0.389889930434728 no 2089 0.39732804931753 2984 4910041 SGTC_715 0868-0130 184 µM -0.260281511080395 0.389884880253846 no 2090 0.397323316631052 3037 2876258 SGTC_2925 9010536 32.5 µM -0.260511775887576 0.389790123370896 no 2091 0.397234516489772 2922 2994177 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.261719285984129 0.38929332503927 no 2092 0.396768935299379 2988 688662 SGTC_1124 fisetin 1.16336 µM -0.262419471517476 0.389005334888544 no 2093 0.396499031225027 2924 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_107 0358-0022 2.6945 µM -0.263508150129741 0.388557676558802 no 2094 0.396079471286987 2945 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_851 0394-0702 453 µM -0.264541866326257 0.388132755392508 no 2095 0.395681204392848 3002 762646 SGTC_2390 9097792 176.6 µM -0.265102217648868 0.387902472335089 no 2096 0.395465359503146 2876 4497149 SGTC_214 4373-3496 70 µM -0.265156522407477 0.387880157240864 no 2097 0.395444443249693 2912 3779166 SGTC_2934 9036370 36.88 µM -0.265187398745027 0.387867469597399 no 2098 0.395432550921556 2970 6462800 SGTC_59 0330-0160 1.33 µM -0.266576532044451 0.387296773735528 no 2099 0.394897613330226 2905 4293482 SGTC_3169 9102970 49.47 µM -0.267058404194854 0.38709886363293 no 2100 0.394712096703885 2885 17027839 SGTC_1352 1496-0991 99 µM -0.2689727300482 0.386312919642577 no 2101 0.393975333931349 2870 3000039 SGTC_2560 caryophyllene 100 µM -0.269768759731497 0.385986239430393 no 2102 0.393669079075082 2849 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3285 9112818 20.8695 µM -0.270827975571812 0.385551676414827 no 2103 0.393261671148654 2864 17017947 YPR165W RHO1 SGTC_1994 st072947 40.9 µM -0.271285381685148 0.385364061414346 no 2104 0.393085774386527 2989 5286565 YDL195W SEC31 SGTC_51 1013-0126 23.419 µM -0.272655814986796 0.384802109328938 no 2105 0.392558901330805 3152 1627850 SGTC_1477 0139-0234 16 µM -0.273001839479004 0.384660258700019 no 2106 0.39242590078434 2884 620880 SGTC_3259 9138485 49.47 µM -0.274064911660317 0.384224555406609 no 2107 0.392017369110232 3187 17646153 SGTC_1306 1185-0270 9.02 µM -0.274293097427073 0.384131051839184 no 2108 0.391929694314586 3002 1548076 SGTC_921 1561-0023 372 µM -0.275201734912025 0.383758786850277 no 2109 0.391580627073384 2859 24050882 SGTC_1873 rapamycin 2 nM -0.276053410852465 0.383409956135531 no 2110 0.391253521732537 2900 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1065 prochlorperazine maleate 2.48 µM -0.27677299092345 0.383115303076842 no 2111 0.390977210709813 2916 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2183 6420625 130.508 µM -0.278582862816467 0.382374497454582 no 2112 0.390282482871226 2879 2897619 SGTC_1898 st060199 18.6 µM -0.27877654979646 0.382295244133514 no 2113 0.390208155919583 2879 688866 SGTC_3081 9117243 49.47 µM -0.279174543909617 0.382132407389419 no 2114 0.390055439154535 3077 45595589 SGTC_3288 9119690 36.221 µM -0.279375200700718 0.382050317850278 no 2115 0.389978450337365 2943 17595618 YKL019W RAM2 SGTC_1212 0520-0165 585 µM -0.279577008140436 0.381967762923891 no 2116 0.389901024387592 3310 5403258 SGTC_1349 flufenamic acid 69 µM -0.279694370116994 0.381919755222484 no 2117 0.389855999005265 2873 3371 A non-steroidal anti-inflammatory. SGTC_2146 5545642 200 µM -0.279697080699456 0.38191864646205 no 2118 0.389854959120234 2921 825326 SGTC_351 caspofungin 25 nM -0.279913495433272 0.381830125406904 no 2119 0.389771936542137 2922 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1174 0739-0097 51.1 µM -0.280696579581821 0.381509868766841 no 2120 0.389471566212392 2943 728447 SGTC_678 1218-2179 85.9 µM -0.280824372130344 0.381457613349884 no 2121 0.389422554638199 2929 6820081 YOR116C RPO31 SGTC_2271 7849410 118.62 µM -0.281131748739847 0.381331933394142 no 2122 0.389304675380029 2977 972430 SGTC_1461 k072-0203 53.8 µM -0.281468632959169 0.381194202758468 no 2123 0.389175491621918 2898 5418714 SGTC_1852 st056254 31.4 µM -0.282938195697092 0.380593567765216 no 2124 0.388612107214735 2900 442583 SGTC_3115 9123671 49.47 µM -0.284074101771309 0.380129500915387 no 2125 0.388176796760738 2926 3286988 SGTC_102 gallobenzophenone 83.616 µM -0.284589474725068 0.379919005585268 no 2126 0.387979337952966 3084 70837 SGTC_3282 9108498 15.4605 µM -0.285103236936338 0.379709203538589 no 2127 0.387782525104797 3002 16459645 SGTC_3122 9126309 49.47 µM -0.285129775161495 0.379698367241135 no 2128 0.387772359581682 2971 17591206 SGTC_2008 4012253 172 µM -0.287335775863104 0.378797926729642 no 2129 0.386927615940923 2894 603940 SGTC_735 3076-0345 636 µM -0.287609357183639 0.37868630263425 no 2130 0.386822890703263 3072 2888990 SGTC_1513 0337-0559 19 µM -0.288550955822078 0.378302197755273 no 2131 0.38646251559565 2935 775073 SGTC_1775 st081588 35.1725 µM -0.289259098150355 0.378013405537424 no 2132 0.386191554976789 2915 1426443 YGL099W LSG1 SGTC_3114 9122766 49.47 µM -0.289712606245176 0.377828493182754 no 2133 0.386018055679583 2981 17176985 SGTC_3140 9094243 49.47 µM -0.289729476204065 0.377821615203977 no 2134 0.386011602152696 2935 19291112 SGTC_324 1315-0088 19.6 µM -0.289896127018106 0.377753672795002 no 2135 0.385947852328571 2987 6787421 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.292874115975953 0.376540206312546 no 2136 0.384809187115724 3024 7104 SGTC_670 4204-0025 119 µM -0.293140081736645 0.376431890104164 no 2137 0.384707540477709 3030 719039 SGTC_698 k064-0052 127 µM -0.295571652860552 0.375442069746924 no 2138 0.383778612291165 2950 5088751 SGTC_896 0964-0007 44.5 µM -0.295644218787302 0.375412542874115 no 2139 0.383750900308027 3034 6756758 SGTC_728 3030-5151 22.5 µM -0.296793061645046 0.374945179273155 no 2140 0.383312251470108 2919 3125388 SGTC_2892 9047358 58.44 µM -0.297140127524476 0.374804024620485 no 2141 0.383179764871297 2975 6466771 SGTC_774 k060-0086 136 µM -0.297400206758925 0.374698259169587 no 2142 0.383080492924597 3094 5911235 SGTC_3103 9120822 49.47 µM -0.297545352470401 0.374639237402417 no 2143 0.383025094310161 3155 17141819 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.298298549504843 0.374333006028284 no 2144 0.38273765562735 2953 66535 A nucleotide analog. SGTC_3024 9090631 49.47 µM -0.298309745015959 0.374328454806422 no 2145 0.382733383629111 3057 25236383 SGTC_1968 st069590 43.6 µM -0.298323472565412 0.374322874279107 no 2146 0.382728145471739 3076 6384066 SGTC_101 0490-5701 117.494 µM -0.299333264533555 0.373912445638338 no 2147 0.382342888008041 2919 4661669 SGTC_3276 9139060 49.47 µM -0.299576015295207 0.373813801195116 no 2148 0.382250290690902 2903 4870619 SGTC_1385 3091-4834 14.1 µM -0.300329758605493 0.373507562004733 no 2149 0.381962818119802 3039 4072814 SGTC_2361 9034121 116 µM -0.301412726248305 0.373067701747523 no 2150 0.381549895572209 2957 6496917 SGTC_2143 5623677 140.463 µM -0.301468730684296 0.373044959369272 no 2151 0.381528545414809 2939 5375313 SGTC_144 4161-2749 112.381 µM -0.303780455886302 0.372106596862401 no 2152 0.380647578731999 2956 797501 YMR168C CEP3 SGTC_526 4469-0568 170 µM -0.305593916330176 0.371371018100407 no 2153 0.379956926546017 2937 2901964 SGTC_2730 imipramine 71.33 µM -0.306658462646177 0.370939433639054 no 2154 0.379551674667899 2957 3696 A tricyclic antidepressant. SGTC_42 0133-0086 60.653 µM -0.308555050839894 0.370170928265813 no 2155 0.378830008806329 2890 162923 Model of phenazepam hydroxylation. SGTC_1581 himbacine 57.9 µM -0.30930288198394 0.369868046219563 no 2156 0.378545569441541 2951 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1518 st038567 90.8 µM -0.31010110015255 0.369544845772061 no 2157 0.378242037837961 2981 77966 SGTC_1750 st081859 2.357 µM -0.310501725361118 0.36938266638613 no 2158 0.378089723815701 2971 5291695 SGTC_1063 disulfiram 1.84 µM -0.310559429020192 0.369359308951484 no 2159 0.378067786975291 2958 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1365 1672-3266 55.4 µM -0.311776060000236 0.368866950345292 no 2160 0.377605359583231 3065 6415873 SGTC_558 k064-0027 21.3 µM -0.311933879934219 0.368803097914566 no 2161 0.377545386884981 3054 5088526 SGTC_2642 cholecalciferol 100 µM -0.312158555184631 0.368712202712183 no 2162 0.377460013784199 3048 9821465 A vitamin D precursor, similar to steriods. SGTC_500 h-89 112 µM -0.313144178266234 0.36831354331842 no 2163 0.377085563140009 3127 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_719 2810-4230 27.3 µM -0.313868754896695 0.36802056092644 no 2164 0.376810361016829 2951 721079 SGTC_1960 st011366 51.8 µM -0.314673058390535 0.367695430887964 no 2165 0.376504951052628 2940 3972846 SGTC_1491 4138-0063 26.5 µM -0.31508644036551 0.367528363048149 no 2166 0.376348011788707 3055 23883227 SGTC_3106 9121286 49.47 µM -0.315229083326554 0.367470719878848 no 2167 0.376293862545861 3162 15943471 SGTC_1112 tnp00069 1.16933 µM -0.31788604787063 0.366397566200438 no 2168 0.375285688138053 3059 145826 SGTC_1166 k206-0078 225 µM -0.318468797880793 0.366162331515115 no 2169 0.375064679604702 2953 5404595 SGTC_3279 9140807 49.47 µM -0.319429583030963 0.365774607830253 no 2170 0.374700390442416 2960 45595718 SGTC_1330 1469-0054 61.8 µM -0.320307935266054 0.365420269765985 no 2171 0.37436745416302 3110 7102664 SGTC_3165 9101544 49.47 µM -0.323061844501773 0.364310054688804 no 2172 0.373324202909739 3071 5002184 SGTC_3228 9131799 49.47 µM -0.323132480273042 0.364281593402015 no 2173 0.373297456445949 3029 17015818 SGTC_957 1187-1561 14.1 µM -0.324121029813845 0.363883355509153 no 2174 0.372923203067483 3006 1538454 SGTC_1790 st045711 43.5 µM -0.32428695364367 0.363816527368749 no 2175 0.372860397973899 3139 585119 SGTC_940 3232-1287 54.8 µM -0.326011661962812 0.363122122656282 no 2176 0.372207765891013 3020 1585493 YIL048W NEO1 SGTC_2125 5246583 200 µM -0.326056359537553 0.363104132418706 no 2177 0.372190857134537 3140 835267 SGTC_3192 9110362 49.47 µM -0.326433260954072 0.362952446135468 no 2178 0.372048287965027 2961 16649480 SGTC_848 0368-0089 85.6 µM -0.326447744380326 0.362946617620664 no 2179 0.372042809720299 3100 762535 SGTC_374 0880-0231 82.3 µM -0.326609630497456 0.36288147251495 no 2180 0.371981579302965 3047 6833587 SGTC_1931 st074438 57.1 µM -0.327278682405057 0.362612279320898 no 2181 0.371728557197985 2956 2787313 SGTC_64 000l-0018 272.079 µM -0.327699881242427 0.362442844687061 no 2182 0.371569296596222 2922 6811119 SGTC_3022 9087993 49.47 µM -0.328796674326352 0.362001766879945 no 2183 0.371154688478821 3064 17173644 SGTC_1253 0550-0034 176 µM -0.32892386564651 0.361950628448619 no 2184 0.371106617466623 3101 5969915 SGTC_3314 9135860 59.4275 µM -0.328949075668956 0.361940492821598 no 2185 0.371097089765175 3146 25252478 SGTC_3100 9120536 49.47 µM -0.329168703871174 0.361852195944444 no 2186 0.371014088345238 2974 16421196 SGTC_2836 9010338 19.48 µM -0.329305493937107 0.361797206105198 no 2187 0.370962395968562 2977 2994051 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.32952790151122 0.361707803973902 no 2188 0.3708783540754 3092 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_507 nimesulide 162 µM -0.329641175637865 0.361662273585675 no 2189 0.370835553169734 3175 4495 A COX2 inhibitor. SGTC_1459 k035-0031 35.7 µM -0.332474868356852 0.360523913316549 no 2190 0.369765356782927 2964 3877128 YMR208W ERG12 SGTC_2913 7966556 36.57 µM -0.333976444972945 0.359921195015399 no 2191 0.369198666664126 3127 2976516 SGTC_3300 9124615 50.48 µM -0.334143204552228 0.359854280787177 no 2192 0.369135749650588 3180 24824903 SGTC_195 4234-0266 16.654 µM -0.33478806757588 0.35959556240519 no 2193 0.368892481156245 3025 2303354 SGTC_298 1391-0729 10 µM -0.336461674953365 0.358924413267707 no 2194 0.368261373778925 2985 3237558 SGTC_299 1273-0059 1.44 µM -0.338170495642181 0.358239591971952 no 2195 0.367617354253787 3091 2848077 SGTC_1982 st072467 71.9 µM -0.338330274035935 0.358175582981218 no 2196 0.367557156043611 2946 3163533 SGTC_1336 1486-0901 104 µM -0.339418561830585 0.357739708977466 no 2197 0.367147218671482 3062 5006114 SGTC_673 1082-0474 110 µM -0.339560843927138 0.357682736765808 no 2198 0.367093634885646 3039 3098046 SGTC_1445 4239-0156 97.7 µM -0.3409348742086 0.357132714612027 no 2199 0.366576305073369 3185 4008346 SGTC_811 0416-0114 265 µM -0.342862628923735 0.356361537874262 no 2200 0.365850903644563 3104 6612453 SGTC_2793 7325131 81.82 µM -0.343242883838759 0.356209490359512 no 2201 0.36570787274018 3049 4176441 SGTC_2728 chlorpromazine 9.18 µM -0.343259913279737 0.3562026815563 no 2202 0.365701467641295 2986 2726 A thorazine and dopamine antagonist. SGTC_2109 5483026 200 µM -0.344722128097503 0.355618222104493 no 2203 0.365151640444736 3042 759335 SGTC_712 r015-0009 80.6 µM -0.345834799438618 0.355173705333409 no 2204 0.364733435408631 3110 6813872 YLR060W FRS1 SGTC_1822 st052468 42 µM -0.34685568164296 0.354766031974896 no 2205 0.364349871460953 3071 2873678 SGTC_2694 st077685 81.9 µM -0.350002089400393 0.353510610861449 no 2206 0.363168564797339 2971 2838096 SGTC_2508 celastrol 40.54 µM -0.351193622837801 0.35303560216378 no 2207 0.362721547028123 3054 122724 Celastrol is a natural product and antioxidant. SGTC_182 3448-4371 550.524 µM -0.351261033183115 0.353008735644763 no 2208 0.362696262829352 3053 3491403 SGTC_18 0111-0177 500 nM -0.351546063591605 0.352895144344412 no 2209 0.362589360553435 3042 721752 SGTC_2912 7964298 10.93 µM -0.352029288189762 0.352702597971602 no 2210 0.362408148896045 3099 2975850 SGTC_236 1509-0011 5.31 µM -0.352569732336662 0.352487296507777 no 2211 0.362205516135487 3158 3107280 SGTC_793 0488-0545 106 µM -0.352678560246905 0.352443947494327 no 2212 0.362164717142411 3002 292548 SGTC_2463 5473429 200 µM -0.354038061406027 0.351902584167999 no 2213 0.361655179633931 3075 5399405 SGTC_1531 st059297 52.4 µM -0.355418104984323 0.351353347603986 no 2214 0.361138193658637 3144 7566702 SGTC_2120 5538279 151.968 µM -0.35722154762127 0.350636072346289 no 2215 0.360462978001097 3060 2058197 SGTC_522 1273-0010 11.6 µM -0.357411711890186 0.350560470124111 no 2216 0.360391805099502 3252 5705015 SGTC_2681 menadione 3.18 µM -0.357659182555266 0.35046209387902 no 2217 0.360299191340438 3122 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2991 9074669 71.4286 µM -0.357693856996033 0.350448310657193 no 2218 0.36028621538506 3224 17333109 SGTC_2404 5161160 200 µM -0.358508527213033 0.350124532851107 no 2219 0.359981393811584 2976 2831543 SGTC_983 1491-0821 12.2 µM -0.360818718060846 0.349206977010664 no 2220 0.359117484559768 3155 46495113 SGTC_3212 9128307 49.47 µM -0.361987613350247 0.348743053286307 no 2221 0.358680643387924 2954 27243542 SGTC_55 0767-0285 6.563 µM -0.363268832419581 0.348234808998895 no 2222 0.35820203672601 3143 3116166 SGTC_3309 9129340 25.759 µM -0.363420235466145 0.348174767201611 no 2223 0.358145493958199 3074 17158987 SGTC_156 3474-0145 5.642 µM -0.365315037511368 0.347423669163607 no 2224 0.357438127330092 3165 2265471 SGTC_415 dibenzyl ketone 100 µM -0.365344597797611 0.347411956224953 no 2225 0.357427095769511 3114 7593 SGTC_2865 9030313 51.95 µM -0.366087662190982 0.347117573014783 no 2226 0.357149831800071 3013 42562754 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.36615540468515 0.347090739746729 no 2227 0.357124558395391 3136 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2172 5754775 163.918 µM -0.366176070513405 0.347082554022568 no 2228 0.357116848502307 3038 2263357 SGTC_1746 st038117 42 µM -0.367870804065927 0.346411514073286 no 2229 0.356484785502264 3130 2898218 SGTC_771 0250-0039 27.3 µM -0.368860647405601 0.346019802367475 no 2230 0.356115798482948 3061 3005115 SGTC_2983 9022671 12.99 µM -0.370641844903645 0.345315342381208 no 2231 0.355452155366698 3247 6405161 SGTC_2595 hexamethylquercetagetin 100 µM -0.372507277005462 0.344578141892076 no 2232 0.354757597479325 3107 386331 SGTC_1871 st057448 67.3 µM -0.374152076564566 0.343928622443651 no 2233 0.354145588072388 3272 691747 SGTC_1791 st048313 56.1 µM -0.375564499248756 0.343371234181828 no 2234 0.353620343633555 3158 1204976 SGTC_2833 9001315 45.46 µM -0.376659717956466 0.342939259297791 no 2235 0.353213251057105 3024 2989378 SGTC_2988 9073640 71.4286 µM -0.37760589861531 0.342566233028681 no 2236 0.352861691062142 3269 9102229 SGTC_400 oxethazaine 37.5 µM -0.378341535877994 0.34227631831364 no 2237 0.352588446690331 3141 4621 A local anesthetic. SGTC_117 lucigenin 22.078 µM -0.379378497755476 0.341867809389482 no 2238 0.352203407771331 3158 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1874 staurosporine 7.6 µM -0.37996351086325 0.341637426347804 no 2239 0.351986250754387 3179 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_560 2332-1943 155 µM -0.380057134350078 0.341600562110294 no 2240 0.351951502170369 3084 21177716 SGTC_2763 lisinopril 49.32 µM -0.38202663152752 0.340825423476785 no 2241 0.351220805501739 3123 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_761 k216-0224 480 µM -0.382346680677175 0.34069952449019 no 2242 0.35110211696545 3247 1340404 SGTC_1357 1503-1303 39.5 µM -0.383683509429524 0.340173842917157 no 2243 0.350606518225575 3104 292895 SGTC_2714 st079313 56.9 µM -0.384891062784697 0.339699263210507 no 2244 0.350159063828337 3095 2939799 SGTC_955 1216-0110 33 µM -0.385575723381393 0.339430298009925 no 2245 0.34990545772152 3055 3619719 SGTC_806 3966-4455 5.86 µM -0.385801479800823 0.339341628745892 no 2246 0.349821849634994 3090 714982 SGTC_125 0133-0007 11.75 µM -0.385993189833397 0.339266338701182 no 2247 0.349750856223816 3230 26541 SGTC_2796 7949634 45.45 µM -0.386534139564477 0.339053926787553 no 2248 0.349550561880122 3041 2971588 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.386807161661916 0.338946740041452 no 2249 0.34944948745751 3085 2724 A muscle relaxant with antifungal properties. SGTC_2851 9015922 71.43 µM -0.387462565411401 0.338689485907635 no 2250 0.349206896624962 3247 2996893 SGTC_2727 riluzole 51.77 µM -0.388061861386858 0.33845432061959 no 2251 0.34898512740775 3129 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2182 6325192 200 µM -0.389078267030679 0.338055624457958 no 2252 0.34860912487213 3186 736248 SGTC_1103 duloxetine 36.1 µM -0.391127434421149 0.33725236868469 no 2253 0.347851521464319 3235 60835 A selective serotonin reuptake inhibitor. SGTC_1316 1272-0050 65.9 µM -0.391848662768242 0.336969829627894 no 2254 0.34758501838496 3094 7340392 SGTC_396 dithiazanine 1.25 µM -0.392397686627303 0.336754812800516 no 2255 0.347382197537656 3095 10578 An antihelmenthic. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.392424989374341 0.336744121487631 no 2256 0.347372112474246 3037 4000243 SGTC_706 4262-0057 46.9 µM -0.392632711619153 0.336662785146698 no 2257 0.347295387762627 3076 883298 SGTC_3267 9137951 49.47 µM -0.39435625842304 0.33598820303179 no 2258 0.346659016620969 3035 16643986 SGTC_2056 5235370 200 µM -0.39503038279603 0.335724499778141 no 2259 0.346410232716607 3094 5511916 SGTC_2769 toremifene 3.73 µM -0.396418928080231 0.335181585078042 no 2260 0.345898002422265 3296 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_202 3594-0513 34.79 µM -0.39656225508324 0.335125564466377 no 2261 0.345845145545338 3120 708429 SGTC_1150 3909-7983 10.9 µM -0.39866189137227 0.334305324194791 no 2262 0.345071175598259 3129 23965914 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.400304619073137 0.333664129974656 no 2263 0.344466083116892 3039 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2873 9040596 71.43 µM -0.400337438277652 0.333651324828692 no 2264 0.344453998336388 3217 6463863 SGTC_3171 9103192 49.47 µM -0.401801313540066 0.333080358458704 no 2265 0.343915127688175 3223 13018434 SGTC_3345 9148410 3.559 µM -0.403139286367351 0.332558836954957 no 2266 0.343422880421326 3231 4903596 SGTC_3098 9119039 49.47 µM -0.404000779584703 0.332223211329514 no 2267 0.343106072951703 3166 17161528 SGTC_2618 avocadyne 43.43 µM -0.405414313878575 0.331672809801067 no 2268 0.342586495578906 3099 3015189 SGTC_1010 4112-3296 15.2 µM -0.406235027381353 0.331353407214624 no 2269 0.342284959793919 3263 704384 SGTC_130 0136-0219 337.655 µM -0.406949721048738 0.331075364959374 no 2270 0.342022458297329 3087 234244 SGTC_34 0469-0683 81.75 µM -0.407097230134913 0.331017990061205 no 2271 0.341968288842461 3190 3690923 SGTC_2471 5466956 24.79 µM -0.408931066592633 0.33030503564229 no 2272 0.341295124796146 3097 724419 SGTC_1829 berberine 14.4 µM -0.409192233932955 0.330203549666772 no 2273 0.341199296587024 3266 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1066 ketoconazole 628 nM -0.410266329047729 0.329786302714593 no 2274 0.340805294495733 3250 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1638 st008370 60.6 µM -0.411160485273299 0.32943911694866 no 2275 0.340477430394651 3188 24207134 SGTC_1579 chlormadinone acetate 49.4 µM -0.411391573891323 0.329349413030305 no 2276 0.340392715728271 3240 45114258 A steroidal progestin. SGTC_1146 3579-1023 7 µM -0.411702662783341 0.329228670137547 no 2277 0.340278686518013 3236 X1146 SGTC_749 1000-0129 128 µM -0.412573143139802 0.32889090537795 no 2278 0.339959690758958 3294 708470 SGTC_1539 benzyladenosine 56 µM -0.413585935315051 0.3284980964431 no 2279 0.339588687664295 3127 92208 A nucleotide analog. SGTC_170 4197-0004 226 µM -0.413978280302823 0.328345977304213 no 2280 0.339445006721153 3240 218692 SGTC_531 3788-1495 174 µM -0.414152211571733 0.328278550155284 no 2281 0.339381318688995 3067 2896655 SGTC_88 0180-0332 8.668 µM -0.414679358575472 0.32807422763407 no 2282 0.339188322452273 3115 3101745 SGTC_2657 nystatin 74.44 µM -0.416898150475417 0.327214786916869 no 2283 0.338376453214098 3195 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2157 5649910 96.377 µM -0.418485042856525 0.326600671175563 no 2284 0.337796260014602 3127 2858091 SGTC_1635 st007035 42.4 µM -0.419354354750308 0.326264452794773 no 2285 0.337478588919364 3222 3716403 SGTC_964 1287-0107 19.4 µM -0.419872322755172 0.326064188599005 no 2286 0.337289363830232 3293 51516812 YPR165W RHO1 SGTC_1587 estradiol valerate 56.1 µM -0.419987319022249 0.326019733899877 no 2287 0.337247358748409 3284 13791 A steroid. SGTC_103 0844-0104 51.839 µM -0.421446601412521 0.32545582655161 no 2288 0.336714498019284 3250 5375804 SGTC_2384 9036245 200 µM -0.422354167847614 0.325105318919905 no 2289 0.336383262970186 3169 6462766 SGTC_487 nimodipine 119 µM -0.425210211040007 0.324003308473205 no 2290 0.335341720578247 3171 4497 L-type voltage-gated calcium channels inhibitor SGTC_794 k038-0031 316 µM -0.425337669618295 0.323954164146384 no 2291 0.335295268373006 3268 6624242 SGTC_1855 st056195 39.6 µM -0.426518652954738 0.323498957283125 no 2292 0.334864979523445 3292 4028379 SGTC_2621 lithochol-11-enic acid 100 µM -0.426543088517564 0.323489541446573 no 2293 0.334856078762799 3283 6708711 SGTC_2019 4016004 108 µM -0.426556270794579 0.323484461922938 no 2294 0.334851277099257 3210 45595336 SGTC_233 rapamycin 362 pM -0.42824886384874 0.322832528996877 no 2295 0.334234972158012 3233 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3272 9137413 49.47 µM -0.428600137003827 0.322697297876959 no 2296 0.334107122909127 3149 17614870 SGTC_2164 5685496 200 µM -0.429004731464393 0.322541568482847 no 2297 0.33395989070934 3285 759046 SGTC_2439 5492030 7.2 µM -0.429361722469722 0.322404187623109 no 2298 0.333830002659079 3227 5722370 SGTC_1451 4152-0210 104 µM -0.429616678587094 0.322306087694996 no 2299 0.333737251293972 3304 659563 SGTC_770 0389-1121 67.2 µM -0.430355849111407 0.322021745674143 no 2300 0.33346840333834 3320 6753108 SGTC_1503 4585-0012 61.3 µM -0.431855536425952 0.321445170375534 no 2301 0.332923206315179 3306 2922052 SGTC_2803 7707263 71.43 µM -0.432032871784058 0.321377019771683 no 2302 0.332858761054844 3126 2199229 SGTC_459 nigericin 15.3 µM -0.432261034568877 0.321289344853802 no 2303 0.33277585191453 3299 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2521 angolensin 13.4 µM -0.433321500236505 0.320881976033364 no 2304 0.332390610307624 3290 821428 A flavenoid. SGTC_3236 9132701 49.47 µM -0.43431394893782 0.320500930578323 no 2305 0.332030237940755 3232 24282524 SGTC_1109 tnp00067 928.257 nM -0.434431487136791 0.320455814923354 no 2306 0.331987568413604 3200 676295 SGTC_1913 st060213 96.1 µM -0.434962287850332 0.320252106365478 no 2307 0.331794900623301 3329 688959 SGTC_709 3807-1509 243 µM -0.435211176102609 0.320156607682905 no 2308 0.33170457553612 3227 1886677 YPL242C IQG1 SGTC_2776 terbinafine 19.92 µM -0.436285284444965 0.31974460789355 no 2309 0.331314878613639 3246 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1405 3909-7894 12 µM -0.437849763103448 0.319144912711887 no 2310 0.330747597316248 3264 7104060 SGTC_1624 st003710 6.25 µM -0.437948687234573 0.319107009046037 no 2311 0.330711740388004 3276 24207033 SGTC_942 3253-1115 227 µM -0.438954719962872 0.318721646072871 no 2312 0.33034717301623 3345 46497897 SGTC_652 0437-0092 114 µM -0.439314951629593 0.318583706190194 no 2313 0.33021667094429 3211 3091274 SGTC_739 1486-1183 203 µM -0.439881975357554 0.318366632438904 no 2314 0.330011295610312 3293 4346692 SGTC_1678 st019265 80.2 µM -0.44034178554464 0.318190649032748 no 2315 0.329844790501319 3372 5367020 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.4404415925988 0.318152455242498 no 2316 0.32980865311685 3331 16725076 SGTC_1219 1469-0211 33.1 µM -0.440755559451482 0.318032320191016 no 2317 0.329694984729496 3269 6822282 SGTC_2975 9084847 53.72 µM -0.441137572446823 0.317886174047562 no 2318 0.329556702166165 3241 27211724 SGTC_1666 st014829 29 µM -0.441592180062336 0.317712292446811 no 2319 0.329392171882866 3164 3858230 SGTC_1192 1488-0095 21.4 µM -0.442659472721648 0.317304224666797 no 2320 0.329006030221107 3258 915875 SGTC_377 3970-0964 33.1 µM -0.442883656799407 0.31721853850927 no 2321 0.328924944601717 3206 16481235 SGTC_2366 9070441 60.58 µM -0.443719207452588 0.316899266191599 no 2322 0.328622803438526 3176 6837235 SGTC_1770 st043884 66.3 µM -0.444147183037119 0.316735785182168 no 2323 0.328468087734034 3197 670149 SGTC_757 1066-0008 322 µM -0.445194673223521 0.316335808819018 no 2324 0.328089537949214 3285 6842497 SGTC_3036 9090181 49.47 µM -0.450191506345343 0.314430767461238 no 2325 0.326286180062276 3226 25236586 SGTC_2536 dehydroabietamide 32.04 µM -0.450746540390292 0.314219464254671 no 2326 0.326086117577792 3333 3983547 SGTC_376 3970-0862 59.1 µM -0.450760909689242 0.31421399462546 no 2327 0.326080938816371 3290 3135186 SGTC_799 1310-0557 151 µM -0.450780281638316 0.314206620817527 no 2328 0.326073957129934 3335 5354492 SGTC_3193 9111931 49.47 µM -0.451599974660474 0.313894677919881 no 2329 0.325778594136664 3169 17087244 SGTC_2778 tioconazole 65.09 nM -0.456475598305713 0.312041961110949 no 2330 0.324024007054851 3253 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2853 9015042 58.44 µM -0.457390851216826 0.311694696322743 no 2331 0.323695069514461 3102 6457456 SGTC_3063 1327-0034 4 µM -0.457791088264712 0.311542891172938 no 2332 0.323551269477112 3274 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2062 5245942 200 µM -0.460051296920925 0.310686222672392 no 2333 0.32273970050068 3300 1376160 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.461038593009501 0.310312337366239 no 2334 0.322385458394725 3235 2724278 An inhibitor of dopamine biosynthesis. SGTC_1812 st052057 4.327 µM -0.462550964103487 0.309739988195897 no 2335 0.321843131936143 3195 3645418 SGTC_629 3448-6466 76.7 µM -0.463973193348274 0.309202173242492 no 2336 0.321333475759915 3274 573744 SGTC_743 1275-0778 158 µM -0.464128634656663 0.309143417973354 no 2337 0.321277793697103 3296 2849257 YMR203W TOM40 SGTC_1802 st050112 57.9 µM -0.465278726170133 0.308708846564382 no 2338 0.320865933706315 3261 4662563 SGTC_888 0916-0002 6.97 µM -0.465304466462232 0.308699123447263 no 2339 0.320856718353456 3360 2802138 YIL048W NEO1 SGTC_1567 st069303 68.4 µM -0.466136015366215 0.308385087013915 no 2340 0.320559072644256 3310 5581319 SGTC_3079 9117512 49.47 µM -0.468530229754735 0.307481689535143 no 2341 0.319702729135489 3296 7185044 SGTC_1844 rapamycin 4 nM -0.468725038975445 0.30740823435062 no 2342 0.319633093512563 3225 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2484 5809818 12.04 µM -0.469412588440773 0.30714904721794 no 2343 0.319387376024875 3242 2870548 SGTC_1654 st012436 41.8 µM -0.469896761603339 0.306966585113446 no 2344 0.319214389047059 3308 4323132 SGTC_1759 st043059 70 µM -0.470754695369747 0.306643387618985 no 2345 0.318907960317407 3197 669426 SGTC_2664 lyso-paf C-16 73.48 µM -0.47265969814272 0.30592627995813 no 2346 0.318227991967602 3216 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2284 7945075 39.21 µM -0.474608825905971 0.305193331378968 no 2347 0.317532907143267 3335 1245402 SGTC_1578 josamycin 24.2 µM -0.476342499808581 0.304542057600747 no 2348 0.316915196028851 3226 5282165 A P450 substrate. SGTC_1007 4101-0031 70 µM -0.476929398721112 0.304321722707819 no 2349 0.316706198352013 3340 1146276 SGTC_1627 st003713 25.6 µM -0.477781599484589 0.304001914037037 no 2350 0.31640282948617 3305 16195070 YER133W GLC7 SGTC_828 2074-0507 139 µM -0.480436760858594 0.303006463453163 no 2351 0.31545843010475 3358 X828 SGTC_612 0302-0167 22.4 µM -0.48230926941435 0.302305316700438 no 2352 0.314793131713112 3296 235821 SGTC_1986 st071812 45 µM -0.482449431884838 0.302252863210145 no 2353 0.314743356416926 3329 11838594 SGTC_2202 7226349 200 µM -0.48299666574687 0.302048109084374 no 2354 0.314549051835924 3224 844334 SGTC_2000 st075254 36.4 µM -0.483026663649265 0.302036886809734 no 2355 0.314538402060641 3323 17234175 SGTC_2826 7992541 19.48 µM -0.484905602123427 0.301334345736213 no 2356 0.31387165416947 3333 2985066 SGTC_2974 9094440 9.66 µM -0.484984743048401 0.301304770846702 no 2357 0.313843584049057 3388 25236134 SGTC_1187 1391-0724 117 µM -0.486517310293538 0.300732309842318 no 2358 0.313300217624003 3311 6997986 SGTC_2961 9083290 32.55 µM -0.487537650395577 0.300351453802299 no 2359 0.312938684077823 3331 17741490 SGTC_1026 k007-1105 30.6 µM -0.488055914782077 0.300158087966816 no 2360 0.312755118106723 3340 7066794 SGTC_2905 7799065 20.05 µM -0.488706070871221 0.299915592622906 no 2361 0.312524902583532 3365 1296806 SGTC_2627 acetyl isogambogic acid 100 µM -0.489431624101443 0.299645080380221 no 2362 0.31226807583654 3331 6857789 A caspase activator and apoptosis inducer. SGTC_3321 9137793 26.8275 µM -0.489880293782693 0.299477855579909 no 2363 0.312109304199968 3344 4904192 SGTC_835 0312-0010 67.2 µM -0.490597629318336 0.299210583587079 no 2364 0.311855531741291 3233 1626196 SGTC_1651 st011928 86.1 µM -0.491615498189303 0.298831521778879 no 2365 0.311495592593256 3350 720198 SGTC_2128 5255449 168.493 µM -0.492325817148917 0.298567123150433 no 2366 0.311244516012577 3255 736008 SGTC_2139 5578692 56.4705 µM -0.492858083028548 0.298369070133267 no 2367 0.31105643342134 3321 650991 YMR113W FOL3 SGTC_2731 amoxapine 43.43 µM -0.493096711403798 0.298280297330514 no 2368 0.310972127210778 3346 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1161 k007-0610 110 µM -0.493455749048074 0.298146753405985 no 2369 0.31084529969945 3407 5843850 SGTC_365 0121-0052 13.6 µM -0.496617056288089 0.296972083846831 no 2370 0.309729561488933 3366 3101739 SGTC_278 4092-0821 23.9 µM -0.497342344345077 0.296702882251858 no 2371 0.309473827976573 3346 877900 SGTC_1367 1812-0510 76.9 µM -0.498761434390932 0.296176489060903 no 2372 0.308973729669192 3316 1142582 YDR527W RBA50 SGTC_1416 3966-0321 25.3 µM -0.499200195943246 0.296013822865055 no 2373 0.308819178282913 3316 582530 YLR208W SEC13 SGTC_2635 hydroquinidine 100 µM -0.50000228680058 0.295716562239917 no 2374 0.308536733623254 3300 442912 An experimental heart treatment. SGTC_2329 6138490 200 µM -0.501463302278523 0.295175452221436 no 2375 0.308022549334226 3376 720019 SGTC_1233 0325-0408 14.2 µM -0.502834963333257 0.294667851310505 no 2376 0.307540154823869 3381 12874 SGTC_293 4049-0273 38.5 µM -0.503050395822652 0.294588164329259 no 2377 0.307464420355747 3299 1380311 SGTC_1345 1488-0192 31.4 µM -0.503078715047862 0.294577689984008 no 2378 0.307454465450659 3391 658348 SGTC_3268 9137683 49.47 µM -0.503818863554899 0.294303994473584 no 2379 0.307194335332762 3256 1953228 SGTC_2258 7960471 200 µM -0.503932215748735 0.294262088951718 no 2380 0.30715450551117 3315 2974708 SGTC_592 k241-0073 46.5 µM -0.504122900979121 0.294191600159965 no 2381 0.307087507453028 3391 4230158 SGTC_1322 1348-1070 12 µM -0.504397883122957 0.294089963870612 no 2382 0.306990902660024 3376 6758089 SGTC_2806 7952793 58.44 µM -0.50461760961492 0.294008762317339 no 2383 0.306913719524085 3376 2972490 SGTC_2478 5763493 32.33 µM -0.50488335429972 0.293910568251368 no 2384 0.306820383050793 3288 1365576 YLR208W SEC13 SGTC_277 nystatin 15.5 µM -0.505757927443774 0.29358751599417 no 2385 0.306513298567386 3229 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2427 5545055 42.75 µM -0.506102623815611 0.293460236274315 no 2386 0.306392304357882 3300 5372858 SGTC_1160 4092-0570 10.5 µM -0.507109735889685 0.2930885049488 no 2387 0.306038912080896 3295 4994975 SGTC_2911 7942208 15.64 µM -0.507182169037061 0.2930617778448 no 2388 0.306013502482573 3357 1243384 SGTC_328 k915-0120 63.5 µM -0.508402433040084 0.292611682736882 no 2389 0.305585573428432 3364 6624543 SGTC_1147 3809-1045 12.3 µM -0.508721683442075 0.292493980059588 no 2390 0.305473660680184 3312 325925 SGTC_584 0986-0246 15.4 µM -0.509135516413934 0.292341439013086 no 2391 0.305328619203966 3418 53315 YDR232W HEM1 SGTC_1215 3852-0577 11.2 µM -0.509331894024158 0.292269066120994 no 2392 0.30525980285336 3418 2884876 SGTC_1420 4'-methoxyflavone 42 µM -0.509454284540003 0.292223964606379 no 2393 0.305216917185449 3378 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2534 helenine 20.12 µM -0.510074213027113 0.291995567622596 no 2394 0.304999735168815 3325 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2773 thioridazine 9.09 µM -0.513058798629827 0.290897137524323 no 2395 0.303955095555313 3382 5452 An antipsychotic. SGTC_216 k038-0035 28.382 µM -0.513648527530671 0.290680325725469 no 2396 0.303748872493843 3359 4444231 YPR107C YTH1 SGTC_752 1896-0090 130 µM -0.513700920443626 0.290661067307801 no 2397 0.303730554168587 3385 772567 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.515228504414017 0.290099825489381 no 2398 0.30319667630811 3289 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_691 1548-0686 185 µM -0.515781522035996 0.289896769402781 no 2399 0.303003504765631 3321 46495133 SGTC_1105 epirubicin 18.1 µM -0.517953196092517 0.289100023303704 no 2400 0.302245462614016 3301 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3109 9122853 49.47 µM -0.520445538739775 0.288186901119413 no 2401 0.301376538621888 3357 1234709 SGTC_2071 5230951 39.92 µM -0.521291711616415 0.287877197548229 no 2402 0.301081786992526 3440 1799272 SGTC_1429 4049-0205 9.46 µM -0.521429065677016 0.287826940095686 no 2403 0.301033954024242 3413 22774478 SGTC_2247 cerulenin 830 nM -0.523669315603145 0.287007824745217 no 2404 0.300254280557811 3490 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1381 2324-0066 62.1 µM -0.52482393801438 0.286586085189635 no 2405 0.299852794496407 3372 10885928 SGTC_1091 telmisartan 47.6 µM -0.525027293687175 0.286511837569206 no 2406 0.299782108707783 3428 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_642 0335-0876 158 µM -0.525140536704035 0.286470495127977 no 2407 0.299742749064525 3357 6812350 SGTC_2483 5729050 27.16 µM -0.525449761080091 0.286357618785239 no 2408 0.299635284504752 3469 2865180 SGTC_323 4013-0906 34.3 µM -0.526219719007932 0.286076652391694 no 2409 0.29936777737047 3407 2910086 SGTC_1446 4239-0190 62 µM -0.527181549054741 0.285725853806255 no 2410 0.299033760190551 3304 1340085 SGTC_2952 9073731 13.78 µM -0.527499615291179 0.285609893750754 no 2411 0.298923341759181 3331 16457353 SGTC_2103 5378138 10 µM -0.528109846887702 0.285387479261934 no 2412 0.298711548397546 3457 244142 SGTC_871 0574-0004 149 µM -0.528349870225412 0.285300019235567 no 2413 0.298628262084009 3284 9551173 SGTC_688 0527-0193 473 µM -0.529188417630345 0.284994568472601 no 2414 0.298337375293051 3315 4007154 SGTC_6 0844-0013 19.835 µM -0.529940941108889 0.284720585778513 no 2415 0.298076439526501 3472 1584900 SGTC_3350 9150499 3.57 µM -0.531283477662438 0.284232100485293 no 2416 0.297611176539832 3375 4910996 YPR165W RHO1 SGTC_196 k015-0023 18.111 µM -0.531482665338246 0.284159659697061 no 2417 0.297542175266669 3359 5211998 SGTC_553 k007-0256 45.7 µM -0.531943457116568 0.2839921122921 no 2418 0.297382578833253 3360 6287000 SGTC_1117 retinoic acid 1.10837 µM -0.533279693295666 0.283506514086671 no 2419 0.296919991213226 3463 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2482 5981709 142.65 µM -0.533603982311087 0.283388725069534 no 2420 0.296807776231899 3339 877755 SGTC_254 nsc-64875 3.808 µM -0.533811829723572 0.283313242584728 no 2421 0.296735864198214 3449 56993 SGTC_2276 7947513 42.08 µM -0.534000825976623 0.283244614513631 no 2422 0.296670481303731 3349 2105100 SGTC_2936 9038235 15.59 µM -0.534725407391557 0.282981579374778 no 2423 0.296419874896339 3375 4749415 SGTC_947 3447-0010 211 µM -0.53535015810815 0.282754878631387 no 2424 0.296203874237594 3424 748350 SGTC_933 2914-0560 114 µM -0.535381714200587 0.282743430316171 no 2425 0.296192965983069 3463 463887 SGTC_2223 6903751 107.57 µM -0.535704261137648 0.282626425464304 no 2426 0.296081479095378 3399 5598863 SGTC_128 0906-2981 13.371 µM -0.536296455071847 0.282411665977031 no 2427 0.295876840098235 3433 6740226 SGTC_825 1988-2224 89.6 µM -0.536904922748728 0.282191086596465 no 2428 0.295666645218776 3331 1180859 SGTC_178 4092-0806 87.505 µM -0.538038558805785 0.281780346491234 no 2429 0.295275214323132 3426 2169044 SGTC_2111 5486399 200 µM -0.538290972019111 0.28168893113137 no 2430 0.295188091551892 3407 689674 SGTC_603 3794-0023 45.9 µM -0.53938253846835 0.281293768116513 no 2431 0.294811463552937 3419 3802260 SGTC_1940 st075990 51.1 µM -0.53985311821729 0.281123493959178 no 2432 0.294649165706913 3543 1084979 SGTC_1121 fusaric acid 630.51 nM -0.540042406838836 0.281055015976517 no 2433 0.294583893741713 3307 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1193 1488-0126 41.5 µM -0.540741906573919 0.280802031452027 no 2434 0.294342744735318 3398 1384710 SGTC_2037 5169046 200 µM -0.542199715878454 0.280275147082722 no 2435 0.293840465507374 3432 5718022 SGTC_2225 6654152 15.4 µM -0.542322660087787 0.280230734243823 no 2436 0.293798123971571 3396 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1304 1165-0502 251 µM -0.542638895878815 0.28011651167635 no 2437 0.293689226492995 3345 767425 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.543655598056082 0.279749437589213 no 2438 0.293339246328758 3480 23847180 SGTC_3326 9140064 16.379 µM -0.544996253561883 0.279265759216469 no 2439 0.292878047147058 3354 1868434 SGTC_2999 9069765 71.4286 µM -0.546074871113758 0.278876913486431 no 2440 0.292507236197259 3372 2097066 SGTC_2070 5230947 200 µM -0.546505299073052 0.278721816143318 no 2441 0.292359323088145 3482 2835538 SGTC_3112 9123419 49.47 µM -0.546793699055235 0.27861791964828 no 2442 0.292260236215128 3464 17015854 SGTC_530 4358-1714 28 µM -0.547613731466502 0.278322604925599 no 2443 0.291978579400737 3424 1564641 SGTC_1015 4130-4525 82 µM -0.547745851472521 0.278275039395088 no 2444 0.291933211921347 3329 1363237 SGTC_285 1486-1325 46 µM -0.548163686800369 0.278124637404022 no 2445 0.291789756885138 3458 22310230 SGTC_1288 0973-0013 65.5 µM -0.549679142751519 0.27757947410734 no 2446 0.291269732517844 3459 4315430 SGTC_2864 9034755 47.6 µM -0.550372306923501 0.277330292497062 no 2447 0.291032019491286 3460 4930451 SGTC_869 0564-0080 44.1 µM -0.550995463781666 0.277106370826049 no 2448 0.290818392096719 3395 6843321 SGTC_1619 st003326 88.7 µM -0.551297533976849 0.276997858473186 no 2449 0.290714864350387 3449 2849032 SGTC_447 ml7 120 µM -0.551672722068151 0.276863109026497 no 2450 0.290586301098408 3457 4216 Selective myosin light chain kinase inhibitor. SGTC_2063 5246145 200 µM -0.552660612141601 0.276508460233915 no 2451 0.290247914557482 3463 711240 SGTC_2726 cimetidine 79.27 µM -0.552940376195973 0.27640806648383 no 2452 0.290152119235152 3407 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_371 0195-0006 7.36 µM -0.554581930393916 0.275819352755533 no 2453 0.289590325684269 3379 3928593 SGTC_2706 st078239 82.5 µM -0.555438360326884 0.27551245441105 no 2454 0.289297430203892 3471 15434492 SGTC_1463 k081-0032 34.1 µM -0.556494611924901 0.275134182206785 no 2455 0.28893638839728 3366 977755 SGTC_3286 9117135 37.221 µM -0.556720784901605 0.27505321681757 no 2456 0.288859106828433 3352 3438150 SGTC_2838 9002687 71.43 µM -0.556811683981236 0.275020680076769 no 2457 0.288828050052139 3371 6457060 SGTC_3351 9150312 21.596 µM -0.557700005866013 0.274702810812578 no 2458 0.288524626841446 3414 4904905 SGTC_587 k089-0003 57 µM -0.557762221348206 0.274680554963839 no 2459 0.288503381591301 3432 9659696 SGTC_2553 4-methylesculetin 85.09 µM -0.55847584140602 0.274425340958572 no 2460 0.288259748415947 3421 5319502 SGTC_632 0781-2353 4.65 µM -0.560784849542708 0.27360036653383 no 2461 0.287472108059141 3464 6811515 YHR007C ERG11 SGTC_2436 5633522 8.09 µM -0.562822320590901 0.272873428946978 no 2462 0.286777939820541 3494 5724242 SGTC_2437 5741531 144.16 µM -0.564034059516672 0.272441554303907 no 2463 0.286365476410871 3514 2262990 SGTC_2757 clomiphene 4.22 µM -0.564443547018396 0.272295686057294 no 2464 0.286226154782909 3549 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2626 ethyl orsellinate 100 µM -0.564745348800277 0.272188202622893 no 2465 0.286123492122722 3396 75653 A natural product. SGTC_2487 5918373 44.05 µM -0.565252079978321 0.272007783244491 no 2466 0.285951158833817 3527 2876279 SGTC_2154 5570129 200 µM -0.565449509003521 0.271937505622893 no 2467 0.285884028912963 3490 673366 SGTC_1704 st028805 70.8 µM -0.565598151687652 0.271884600141884 no 2468 0.285833492294193 3435 2876101 SGTC_2367 9070478 135.38 µM -0.565672640859391 0.271858089592948 no 2469 0.285808168522811 3448 572802 SGTC_1484 3473-2379 286 µM -0.565709154171281 0.271845095047189 no 2470 0.285795755634976 3542 671917 SGTC_476 mead acid 10 µM -0.565910776998556 0.271773346040892 no 2471 0.285727217536871 3429 5312531 An omega 9 fatty acid. SGTC_123 0083-0120 66.675 µM -0.566124950882102 0.271697140970449 no 2472 0.285654421495324 3397 16001701 SGTC_654 1124-0271 80.9 µM -0.56681540826102 0.271451542220566 no 2473 0.285419800490433 3414 5403748 SGTC_902 1120-0002 2.07 µM -0.566903645884999 0.271420163678534 no 2474 0.285389823501475 3467 3280475 SGTC_2575 plumbagin 510 nM -0.567700920984387 0.271136723381547 no 2475 0.285119033045584 3399 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1002 4049-0206 172 µM -0.570850305896505 0.270018526587182 no 2476 0.28405055954681 3438 4662749 SGTC_2962 9082311 13.18 µM -0.570878997521116 0.270008350172655 no 2477 0.284040834317232 3388 16459453 SGTC_295 k015-0027 31 µM -0.571443900625984 0.269808028074589 no 2478 0.283849388854526 3454 3887424 SGTC_2690 usnic acid 100 µM -0.574895855289081 0.268585538416311 no 2479 0.28268086660195 3580 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2380 9035439 200 µM -0.575918581905026 0.268223881059359 no 2480 0.282335107534144 3549 6462575 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.57664310114662 0.267967824376195 no 2481 0.282090288336849 3439 4620898 SGTC_1480 1070-0044 41.2 µM -0.577150335557912 0.267788632906135 no 2482 0.281918951779427 3463 3124987 SGTC_2047 4141938 200 µM -0.577290949114434 0.267738968831418 no 2483 0.281871463400588 3421 3807862 SGTC_2469 5655019 90.81 µM -0.577751627723595 0.267576291739784 no 2484 0.281715908818334 3526 2788239 SGTC_2505 galangin 7.89 µM -0.578738763722927 0.267227877300315 no 2485 0.281382727944518 3415 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3312 9133330 71.43 µM -0.578798715403737 0.267206724441081 no 2486 0.281362499014525 3524 17617324 SGTC_2869 9037858 32.47 µM -0.579022134684351 0.267127902458608 no 2487 0.281287118937207 3466 27187042 SGTC_1783 st039459 87.517 µM -0.579360810647476 0.267008440480988 no 2488 0.281172870668983 3537 729761 SGTC_3221 9128209 49.47 µM -0.579563555914378 0.266936938573441 no 2489 0.281104487713622 3455 16460723 SGTC_1437 4092-1038 11.6 µM -0.579833556785514 0.266841732739055 no 2490 0.281013432920996 3451 3977136 SGTC_636 0kpi-0074 126 µM -0.58061164991147 0.266567462937665 no 2491 0.280751109406148 3458 616434 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.580824044832701 0.266492620694206 no 2492 0.280679523928005 3510 688798 SGTC_35 0133-0054 64.071 µM -0.582096257597692 0.266044549829104 no 2493 0.280250922906488 3430 99677 SGTC_661 1304-0007 33.6 µM -0.582259519720028 0.265987076864644 no 2494 0.280195943815961 3459 3117130 SGTC_1281 0884-0031 11.8 µM -0.582297766930175 0.265973613655594 no 2495 0.280183064689748 3473 1548255 SGTC_993 3909-8757 62.7 µM -0.583580909807723 0.265522141113085 no 2496 0.279751153492195 3404 4288324 YLR208W SEC13 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.584021630458663 0.265367163735291 no 2497 0.279602879667658 3419 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_302 1094-0063 18.9 µM -0.584087625020067 0.265343961005695 no 2498 0.279580680075926 3420 5440289 SGTC_1912 st060209 90.8 µM -0.584447936212289 0.265217298982888 no 2499 0.279459491825605 3434 688787 SGTC_1510 1123-0200 71.5 µM -0.584678545794211 0.265136247741199 no 2500 0.279381941232853 3591 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.585253830180485 0.264934110151719 no 2501 0.279188527180379 3471 75037 A free radical scavenger. SGTC_561 1550-0330 72.9 µM -0.586885790820987 0.26436111490168 no 2502 0.278640206718519 3412 6812934 SGTC_163 TUB2.036 7.546 µM -0.588027858515956 0.263960500788183 no 2503 0.278256796939324 3477 15992207 YJR013W GPI14 SGTC_787 4152-0075 138 µM -0.588664621790053 0.263737271615614 no 2504 0.278043137409298 3442 9566539 SGTC_77 0828-0286 12.516 µM -0.589389439603986 0.263483290517863 no 2505 0.277800029512825 3493 745345 SGTC_685 1278-0033 54.9 µM -0.590893685028983 0.262956591350304 no 2506 0.277295828740632 3547 3590572 SGTC_3196 9111891 49.47 µM -0.592652778663559 0.26234134263489 no 2507 0.276706774906265 3523 18891510 SGTC_3006 9075424 71.4286 µM -0.592866543938581 0.262266627804355 no 2508 0.276635234813903 3445 7465181 SGTC_3087 9117406 49.47 µM -0.59396734068853 0.26188205209177 no 2509 0.276266978531593 3499 42546093 SGTC_1302 1159-0335 255 µM -0.594019423140063 0.261863863669989 no 2510 0.276249561031259 3490 649284 SGTC_9 0092-0002 10.449 µM -0.594957448912424 0.261536393868977 no 2511 0.275935957164917 3508 759368 SGTC_72 0744-0168 198.391 µM -0.595647357441792 0.261295677362193 no 2512 0.27570541633085 3407 677577 SGTC_2878 9043973 25.97 µM -0.596431998610384 0.261022046018148 no 2513 0.275443334626302 3548 6465167 SGTC_2920 7982904 15.77 µM -0.597391100469318 0.260687774451719 no 2514 0.275123147041652 3476 6456808 SGTC_1392 3455-1037 33.9 µM -0.598905826150919 0.260160302827911 no 2515 0.274617843032424 3554 981132 SGTC_451 chloral hydrate 100 µM -0.599950245096812 0.25979692640678 no 2516 0.2742696975554 3549 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_306 1672-3436 11.6 µM -0.600741602906736 0.259521770040562 no 2517 0.274006052410011 3535 6797378 SGTC_2299 7976368 114.88 µM -0.601338411125003 0.259314358465133 no 2518 0.273807305395588 3496 2979718 SGTC_2665 lovastatin 100 µM -0.601804356607393 0.259152485794872 no 2519 0.273652187408747 3521 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.602501141526997 0.25891051541755 no 2520 0.273420301780076 3476 23665772 A membrane-active detergent. SGTC_2889 9059656 51.95 µM -0.602998390205454 0.25873790887637 no 2521 0.273254880062036 3531 3949838 SGTC_2585 alliin 100 µM -0.604687308713084 0.258152091126964 no 2522 0.272693391184996 3612 87310 A garlic compound which reacts with lipids. SGTC_1275 0867-0008 21.1 µM -0.606345956968502 0.257577442937543 no 2523 0.272142523610537 3456 3422836 SGTC_1086 cerivastatin 2.18 µM -0.606607413080636 0.257486920620064 no 2524 0.27205573972808 3513 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_591 4299-0174 154 µM -0.607255748209717 0.257262522914542 no 2525 0.271840600321412 3450 5509088 SGTC_2782 7736369 71.43 µM -0.607393324005003 0.257214919116953 no 2526 0.271794958933986 3528 2950836 YOL077C BRX1 SGTC_2588 indole-3-carbinol 100 µM -0.60821329822559 0.256931287718653 no 2527 0.271523007929886 3531 3712 Induces cell cycle arrest. SGTC_1682 st012968 530 nM -0.608303412027224 0.256900127027808 no 2528 0.271493129234801 3412 24207270 SGTC_540 1187-0821 17.3 µM -0.608403474335822 0.256865528520585 no 2529 0.271459953869597 3493 847520 SGTC_889 0919-1524 82.7 µM -0.608788456478055 0.256732436004064 no 2530 0.271332333003142 3501 3905452 SGTC_3191 9110352 49.47 µM -0.609016105010188 0.256653752323441 no 2531 0.271256882007171 3517 17122424 SGTC_1389 3405-0187 19 µM -0.610352391128513 0.256192136157065 no 2532 0.270814199214263 3466 799890 SGTC_2805 7950783 58.44 µM -0.612191331494212 0.255557588056538 no 2533 0.270205588080815 3512 1178958 YDL195W SEC31 SGTC_2359 9039622 200 µM -0.613027528166306 0.255269320286832 no 2534 0.269929068915938 3502 6463596 SGTC_1348 1493-0373 93.8 µM -0.613896961143892 0.254969775101869 no 2535 0.269641709218098 3507 3010129 SGTC_2612 dictamnine 15.46 µM -0.614562181169866 0.254740711529978 no 2536 0.269421948276965 3481 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_114 0364-0001 490.298 µM -0.61511003602866 0.2545521427229 no 2537 0.269241027338017 3527 4003655 SGTC_1232 0279-0259 161 µM -0.61643266395502 0.254097202577515 no 2538 0.268804500379691 3548 1560000 SGTC_3147 9097027 49.47 µM -0.617434651304901 0.253752836308433 no 2539 0.268474036114945 3519 25236841 SGTC_582 0987-0078 156 µM -0.620704294969585 0.252630821279332 no 2540 0.267397101491668 3610 1625765 SGTC_797 k781-0471 270 µM -0.621124560418504 0.252486792227884 no 2541 0.26725883531665 3502 23738129 SGTC_3175 9106517 49.47 µM -0.623826941885067 0.251561694473028 no 2542 0.266370621997938 3537 41468073 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.62422313290352 0.251426218318357 no 2543 0.266240528383295 3530 2374 Ca(2+)-ATPase inhibitor. SGTC_773 4358-1457 44.6 µM -0.624456498988534 0.251346437638558 no 2544 0.266163915154356 3581 1186886 SGTC_2563 tomatine 8.54 µM -0.624499625174183 0.251331695588632 no 2545 0.266149758208031 3585 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1681 tripelennamine 100 µM -0.624558347737702 0.251311622882159 no 2546 0.266130482083112 3557 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_356 1634-0012 32.5 µM -0.625875582709036 0.250861584867472 no 2547 0.265698275620902 3562 735457 SGTC_263 alizarin 107.927 µM -0.62640202584209 0.25068184309127 no 2548 0.265525640562909 3568 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2186 6124449 200 µM -0.626506349743109 0.25064623221839 no 2549 0.265491436667651 3528 3834182 YLR033W RSC58 SGTC_2311 7694451 200 µM -0.6280890863526 0.250106295312146 no 2550 0.264972791041311 3486 2163142 SGTC_711 k292-0785 179 µM -0.629246441390705 0.249711864545187 no 2551 0.26459386448805 3590 4146315 SGTC_2639 lactacystin 53 µM -0.630553559448832 0.249266791535905 no 2552 0.264166236147259 3585 3870 A proteasome inhibitor. SGTC_2867 9039098 71.43 µM -0.630752110897365 0.249199221793209 no 2553 0.264101310143374 3543 6463460 SGTC_1614 st002383 48.6 µM -0.632215517234184 0.248701505451983 no 2554 0.263623029531641 3578 1947235 SGTC_1926 methyl fluorone black 53.6 µM -0.632502962050682 0.248603805384901 no 2555 0.263529136773519 3445 72721 Reacts with homocysteine. SGTC_90 0870-0863 4.608 µM -0.63306880241333 0.248411540773417 no 2556 0.263344357043702 3552 1738164 SGTC_2344 7990960 76.95 µM -0.633172306382372 0.248376380153901 no 2557 0.263310564147512 3537 140813 SGTC_2092 5303694 80.6725 µM -0.634256856882196 0.2480081145653 no 2558 0.262956603675386 3550 1963699 SGTC_3184 9108758 49.47 µM -0.636158874755679 0.247362977203587 no 2559 0.262336437479036 3574 902885 SGTC_3134 9127454 49.47 µM -0.63692426611321 0.247103620702885 no 2560 0.262087087824055 3663 24262820 SGTC_581 0958-0271 211 µM -0.637220007840602 0.24700344618651 no 2561 0.261990773452826 3562 4591145 SGTC_976 1348-1067 47.6 µM -0.63792299483348 0.246765415581368 no 2562 0.26176190414459 3618 5310671 YGL099W LSG1 SGTC_979 1426-2828 121 µM -0.638072600202731 0.246714775225434 no 2563 0.26171321082592 3616 747872 SGTC_681 1642-0006 26.6 µM -0.640698730372227 0.245826755694665 no 2564 0.260859219612025 3589 4446530 SGTC_2243 6634756 200 µM -0.641442135088868 0.245575687143956 no 2565 0.260617732427412 3641 885676 SGTC_3005 9076496 71.4286 µM -0.644927328764877 0.244400478576681 no 2566 0.259487140316764 3609 21368410 SGTC_1879 gemcitabine 100 µM -0.645778528142172 0.244113915004247 no 2567 0.259211397768272 3588 60750 A nucleoside analog which inhibits DNA replication. SGTC_1441 4106-0040 13 µM -0.646258376979512 0.243952449678862 no 2568 0.25905601948626 3588 2904180 SGTC_1607 st000305 50.6 µM -0.646573992630883 0.243846278938891 no 2569 0.258953847278347 3587 5457690 SGTC_517 1365-0151 113 µM -0.646738956358804 0.243790796301704 no 2570 0.258900452936251 3628 768657 SGTC_2244 6635614 200 µM -0.646872508409647 0.243745883419222 no 2571 0.25885722988553 3482 836499 SGTC_2040 5100729 123 µM -0.648238879458911 0.243286636435753 no 2572 0.258415229449548 3592 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2652 actinonin 100 µM -0.648899328571515 0.243064822589523 no 2573 0.258201724376835 3581 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.649175842212357 0.242971987133271 no 2574 0.25811236227057 3539 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2280 7785178 200 µM -0.65007346711055 0.242670754795273 no 2575 0.25782238352637 3580 2954328 SGTC_1970 st070122 35.8 µM -0.65139326558448 0.242228213426077 no 2576 0.257396328375268 3640 102928 SGTC_2597 laccaic acid a 100 µM -0.651931006157285 0.24204802924455 no 2577 0.257222840809915 3559 5491415 A textile dye. SGTC_2956 9076196 2.52 µM -0.653286086991907 0.24159429616582 no 2578 0.256785930098104 3643 16423868 SGTC_456 gingerol 170 µM -0.653709734427993 0.241452537560399 no 2579 0.256649415262628 3662 442793 A herb. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.653747185770818 0.241440007969273 no 2580 0.256637348876476 3584 6312947 SGTC_1992 st073643 23.3 µM -0.653914144502685 0.241384155133036 no 2581 0.256583560313306 3596 3161292 SGTC_3016 9080866 49.47 µM -0.654204522476141 0.241287031483313 no 2582 0.256490024154192 3597 17066299 SGTC_3148 9097893 49.47 µM -0.654772792937201 0.241097021704324 no 2583 0.256307025055656 3526 17174100 SGTC_421 streptovitacin 30 mM -0.655747956464216 0.240771150774155 no 2584 0.255993153594787 3623 91467 include heat shock SGTC_1721 st082152 9.2685 µM -0.656102408886978 0.240652762632592 no 2585 0.255879117311896 3582 5296051 SGTC_1375 2910-0797 186 µM -0.656580445641491 0.240493147161608 no 2586 0.255725362831257 3584 742508 SGTC_2719 novobiocin 32.65 µM -0.657549181844011 0.240169865039692 no 2587 0.255413929061693 3613 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1914 st062367 72.6 µM -0.658134822252484 0.239974542792406 no 2588 0.255225750864244 3593 978205 SGTC_2733 amorolfine 100 µM -0.65851190699229 0.239848823697319 no 2589 0.255104624228653 3614 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2268 7933382 153.85 µM -0.65920437279189 0.239618050954115 no 2590 0.254882269656142 3639 935025 YOR257W CDC31 SGTC_2465 5809242 33.21 µM -0.659750810584641 0.239436029428646 no 2591 0.254706877109512 3610 2731748 SGTC_404 fumagillin 50 µM -0.659865217704709 0.239397929330383 no 2592 0.254670163354747 3588 12015870 A methionine aminopeptidase binder. SGTC_2971 9092186 9.93 µM -0.66015875758241 0.239300189214964 no 2593 0.254575977778411 3549 25236400 SGTC_373 0844-0104 25.9 µM -0.660397608913138 0.239220674860211 no 2594 0.25449935310462 3619 5375804 SGTC_2957 9076800 11.52 µM -0.660840392699484 0.23907330894883 no 2595 0.254357337873389 3548 16459615 SGTC_381 3461-2219 42.7 µM -0.660846349431168 0.239071326786403 no 2596 0.254355427638063 3597 2883159 SGTC_158 k038-0087 26.446 µM -0.661142424804406 0.238972816046581 no 2597 0.254260490142268 3574 X158 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.663768495705983 0.238100037118346 no 2598 0.253419246148335 3597 2346 DNA damaging agent; causes G2/M arrest. SGTC_765 1319-0117 244 µM -0.664873413814924 0.237733338583557 no 2599 0.253065730845263 3604 3487746 YGL099W LSG1 SGTC_2977 9011197 71.43 µM -0.666428896039981 0.23721763299559 no 2600 0.252568498918976 3637 2704722 SGTC_2718 lomofungin 53.02 µM -0.666514246426559 0.237189353668211 no 2601 0.25254123036232 3648 5351222 A RNA synthesis inhibitor. SGTC_1922 5578187 25 µM -0.666789155891333 0.237098279913776 no 2602 0.252453410206084 3653 1350412 SGTC_1226 3909-7979 35.4 µM -0.668249605637279 0.236614775175714 no 2603 0.251987137780248 3634 6615510 SGTC_2431 5490079 200 µM -0.66888906701804 0.236403242362812 no 2604 0.251783122435965 3646 5722345 SGTC_3030 9087619 49.47 µM -0.669501636969912 0.236200702856578 no 2605 0.251587768417548 3597 25236973 SGTC_43 0570-0105 72.5 µM -0.669862801029658 0.236081332739157 no 2606 0.251472627512365 3662 1114046 YDL195W SEC31 SGTC_1826 st055655 41.6 µM -0.669976418720302 0.236043787268655 no 2607 0.251436411384299 3643 676168 SGTC_3208 9114115 49.47 µM -0.67077132768586 0.235781198123014 no 2608 0.251183107855876 3599 650895 SGTC_1085 doxorubicin 7.67 µM -0.670946480581921 0.235723360016345 no 2609 0.251127312261317 3645 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1953 st076800 12.1 µM -0.670998167414603 0.235706293746126 no 2610 0.251110848484897 3601 297591 SGTC_2101 5377231 179.231 µM -0.672942543570607 0.23506478309596 no 2611 0.250491922456812 3629 2844213 SGTC_389 tpck 16.7 µM -0.672983670685681 0.235051224395354 no 2612 0.250478839773997 3615 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2786 7743617 45.45 µM -0.67325341923801 0.234962304971817 no 2613 0.250393040768562 3555 583674 SGTC_3167 9103034 49.47 µM -0.674151440816205 0.234666416746292 no 2614 0.25010751905991 3636 5127859 SGTC_1428 4049-0204 61.7 µM -0.674247151515589 0.234634893279222 no 2615 0.250077098484121 3673 X1428 SGTC_3129 9127257 49.47 µM -0.67521544932891 0.234316104505191 no 2616 0.249769446266944 3550 837894 SGTC_1136 pergolide 1.05886 µM -0.67604975152794 0.234041622935757 no 2617 0.249504529038597 3622 47811 A dopamine receptor agonist. SGTC_2385 9074692 200 µM -0.677186412366736 0.23366795353349 no 2618 0.2491438438307 3628 17046906 SGTC_733 4069-0007 56.1 µM -0.677278812928474 0.233637592030384 no 2619 0.249114535478927 3673 5717425 YNL287W SEC21 SGTC_1956 st077085 54 µM -0.677439292517319 0.23358486593134 no 2620 0.249063637633902 3646 24208685 SGTC_2356 9061756 188.97 µM -0.678109706462506 0.233364670589621 no 2621 0.248851068415106 3618 20104043 SGTC_922 1866-0035 480 µM -0.678559243063788 0.233217086241471 no 2622 0.248708587236692 3633 3156169 SGTC_3207 9114163 49.47 µM -0.679004071358532 0.233071098655026 no 2623 0.248567641136879 3685 849233 SGTC_628 1636-0253 16 µM -0.67939026198889 0.232944396443628 no 2624 0.248445309196054 3626 4456143 SGTC_1711 st032263 62.8 µM -0.680049793736085 0.232728104404938 no 2625 0.248236466376769 3655 3958979 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.681591571838246 0.23222291723445 no 2626 0.247748622878694 3653 16486 A toxic proline analog. SGTC_1781 st038725 66.3 µM -0.681608782116036 0.232217281469853 no 2627 0.247743180159339 3662 4270275 YIL048W NEO1 SGTC_3293 9120939 62.045 µM -0.682483331369864 0.231930997371562 no 2628 0.24746668960658 3650 934087 SGTC_963 1269-2853 151 µM -0.683014120331312 0.231757339253248 no 2629 0.247298960023947 3637 3668223 SGTC_1933 st074711 15.9 µM -0.683070682891166 0.231738837964002 no 2630 0.247281089810292 3643 17250958 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.683293096832682 0.231666095618538 no 2631 0.247210827680073 3686 6708561 SGTC_3194 9111903 49.47 µM -0.68337687182669 0.231638699603357 no 2632 0.24718436533774 3658 17087251 SGTC_2416 tofa 880 nM -0.683711756563719 0.2315292039664 no 2633 0.247078599089517 3608 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1323 1348-1351 11.2 µM -0.68437473616631 0.23131251787205 no 2634 0.246869282455672 3612 6989654 SGTC_2464 5717415 7.67 µM -0.68589535000214 0.230815952899555 no 2635 0.246389551338818 3598 5285744 SGTC_486 niguldipine 82 µM -0.688687262137964 0.229905790234417 no 2636 0.245510046892967 3661 1236 A calcium channel blocker. SGTC_1559 coumarin 343 70.1 µM -0.689561278549301 0.229621274557598 no 2637 0.245235062464351 3671 108770 A hepatotoxic, DNA x-linker. SGTC_1851 st056236 18.9 µM -0.68989049672389 0.229514156413466 no 2638 0.245131526271598 3666 5393171 SGTC_2875 9039966 71.43 µM -0.693277632951907 0.228413706898476 no 2639 0.244067668454004 3705 6463691 SGTC_1896 st058441 89 µM -0.693449228218702 0.228358036183712 no 2640 0.244013838846205 3648 688759 SGTC_1195 1502-0147 41.1 µM -0.69416285529029 0.228126595707937 no 2641 0.243790042031906 3672 817940 SGTC_3306 9127676 59.7925 µM -0.695834259927396 0.227585049471512 no 2642 0.243266315553099 3672 41905287 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.695936556077828 0.227551928361409 no 2643 0.243234281315426 3716 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_903 1134-0042 114 µM -0.69703855655817 0.227195298449625 no 2644 0.242889332374666 3667 701009 SGTC_1523 st012844 44.7 µM -0.697246296940431 0.227128104717793 no 2645 0.242824335003715 3729 4274103 SGTC_1070 indatraline 8.81 µM -0.698957757890572 0.226574958317879 no 2646 0.242289215108263 3673 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_883 0850-0245 24.6 µM -0.699029955555642 0.226551640667407 no 2647 0.242266655231444 3723 6823229 YPR165W RHO1 SGTC_1403 3909-7815 62.9 µM -0.701199337241448 0.225851628572808 no 2648 0.241589311699931 3633 6615483 SGTC_11 0438-0307 1.3 µM -0.701265190997778 0.225830398150415 no 2649 0.241568766350858 3666 4011476 SGTC_1782 st039423 80.636 µM -0.701333910761399 0.22580824496681 no 2650 0.241547327863645 3676 2068169 SGTC_2751 anetholtrithion 17.25 µM -0.701973041962035 0.225602267186873 no 2651 0.241347987763321 3661 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1583 clindamycin 39.6 µM -0.703343006198769 0.225161116556809 no 2652 0.240921007755642 3622 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.703905972878447 0.224979973953151 no 2653 0.24074566578381 3698 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2816 7982706 58.44 µM -0.704204279035628 0.224884023155745 no 2654 0.240652783308567 3692 2981853 SGTC_2540 epiandrosterone 100 µM -0.704991886635335 0.224630799042381 no 2655 0.240407642635751 3758 441302 A steroid. SGTC_1119 parthenolide 318.541 nM -0.706627260723415 0.224105526025749 no 2656 0.239899071707541 3799 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1756 st041558 35.5 µM -0.707685256796718 0.223766075601235 no 2657 0.239570367474964 3742 3955792 SGTC_1320 1313-0481 95.3 µM -0.707686784240728 0.223765585743204 no 2658 0.239569893097781 3708 6813365 YLR208W SEC13 SGTC_647 0140-0236 81 µM -0.707767675614034 0.223739644394021 no 2659 0.239544771455045 3686 990837 SGTC_2330 7979373 200 µM -0.708560117506419 0.223485603748311 no 2660 0.239298746596282 3659 1863007 SGTC_2607 solasodine 47.35 µM -0.709928348332338 0.223047363427925 no 2661 0.238874284991564 3713 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1425 4048-4433 7.33 µM -0.71037483198996 0.222904461996914 no 2662 0.238735863042688 3746 23734946 SGTC_1368 1852-0141 284 µM -0.710454984573026 0.222878813907295 no 2663 0.238711018232079 3665 2838987 SGTC_2265 7929201 200 µM -0.711534505441909 0.222533541008116 no 2664 0.238376538173953 3692 1265108 SGTC_2022 5136654 200 µM -0.711961413017902 0.222397083505127 no 2665 0.238244335464217 3702 1713771 SGTC_2761 levamisole 97.89 µM -0.712943734742054 0.222083273757812 no 2666 0.237940287341279 3698 26879 An alkaline phosphatase inhibitor. SGTC_1471 k673-0312 37 µM -0.713651049153705 0.221857473685896 no 2667 0.237721491261976 3688 24099884 SGTC_2106 5357045 167.29 µM -0.7152599761355 0.22134433527934 no 2668 0.237224207486945 3729 668842 SGTC_1227 3909-8010 46.6 µM -0.716893856167095 0.220823933824473 no 2669 0.23671979659873 3688 15982272 SGTC_2399 5884133 200 µM -0.718363693371334 0.220356380263682 no 2670 0.236266533466738 3723 722445 SGTC_3049 9092223 49.47 µM -0.720841045438154 0.219569623062393 no 2671 0.235503659289607 3674 8623917 SGTC_3244 9134489 49.47 µM -0.722886143024397 0.218921358607607 no 2672 0.234874918768347 3683 16584271 SGTC_301 4119-0100 24.5 µM -0.723262308180663 0.218802240038895 no 2673 0.234759372436801 3736 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_65 0798-0905 34.986 µM -0.725812567123856 0.217995644885327 no 2674 0.233976840865642 3801 3602145 SGTC_1563 conessine 56.1 µM -0.727064754788046 0.21760023168732 no 2675 0.233593144201295 3786 441082 An anti-amoebic, histamine inhibitor. SGTC_1488 4013-0813 75.9 µM -0.727420862912197 0.217487856248244 no 2676 0.233484088931391 3685 2910057 SGTC_1378 2093-0007 380 nM -0.728749833451618 0.217068774902083 no 2677 0.233077351768223 3753 3618014 SGTC_2386 9075165 157.42 µM -0.729500492021525 0.216832266462701 no 2678 0.232847783461323 3694 16452277 SGTC_2321 7390090 138.78 µM -0.72962819105205 0.216792047427306 no 2679 0.232808742726899 3708 649046 SGTC_1497 4476-2978 41.3 µM -0.732029432540278 0.216036575716157 no 2680 0.232075301734191 3740 1528379 SGTC_1286 0929-0070 131 µM -0.732896603930863 0.215764124000993 no 2681 0.231810747293428 3802 1420408 SGTC_1465 k213-0056 144 µM -0.73301400786411 0.215727252831413 no 2682 0.231774942916872 3630 24048857 YMR208W ERG12 SGTC_3009 9080819 71.4286 µM -0.733208344262815 0.215666228744347 no 2683 0.23171568341483 3757 17027216 SGTC_2364 9055074 200 µM -0.733672581204016 0.215520492990513 no 2684 0.231574156617796 3740 6470630 SGTC_2592 piperlongumine 83.33 µM -0.734785143384478 0.215171464052107 no 2685 0.231235178235286 3741 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2140 5586273 200 µM -0.738014117108717 0.214160342139833 no 2686 0.230252935272989 3706 854421 SGTC_1722 st034304 3.6505 µM -0.738263002344882 0.214082521064238 no 2687 0.230177322207648 3759 4036148 YLR033W RSC58 SGTC_805 3852-0218 479 µM -0.739975502240252 0.213547505446845 no 2688 0.229657429589942 3696 6615355 SGTC_1501 4491-0275 38.4 µM -0.740199048334442 0.213477723182776 no 2689 0.229589612480883 3718 5104718 SGTC_2973 9094665 17.96 µM -0.741294771748889 0.213135873868528 no 2690 0.229257365527324 3780 25237061 YIL048W NEO1 SGTC_1648 st011736 69.8 µM -0.741786421321048 0.212982590392269 no 2691 0.22910837444632 3758 2855514 SGTC_1406 3909-7906 11.9 µM -0.742106583063051 0.212882806927525 no 2692 0.229011380800371 3748 X1406 SGTC_3355 9151058 44.0485 µM -0.742279241610244 0.212829006490156 no 2693 0.228959083108627 3751 17015728 SGTC_1520 flindersine 88 µM -0.743089283403313 0.21257670329151 no 2694 0.228713813673777 3827 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1801 st050089 28.441 µM -0.744121238225036 0.212255534148981 no 2695 0.228401565836512 3769 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1526 st051518 75 µM -0.744755782604267 0.212058189582784 no 2696 0.228209685037691 3747 673993 SGTC_769 0302-0231 76 µM -0.745064172542657 0.211962318454489 no 2697 0.228116463289547 3732 571869 YER009W NTF2 SGTC_1990 st072050 59.8 µM -0.745817317740463 0.211728290035121 no 2698 0.227888888588893 3752 17233948 SGTC_2060 5238662 140 µM -0.747518833539117 0.211200126937376 no 2699 0.227375219334261 3734 790130 SGTC_850 0388-0143 75.9 µM -0.748871869675909 0.210780686075723 no 2700 0.22696721833336 3720 67273 SGTC_693 4161-2696 114 µM -0.74998994155081 0.210434453046771 no 2701 0.226630381363854 3787 805759 SGTC_722 3534-0461 190 µM -0.749989978181826 0.210434441708726 no 2702 0.226630370332801 3749 658262 SGTC_1730 st033808 45.1 µM -0.750937824917222 0.210141183910583 no 2703 0.226345037528227 3729 1045166 SGTC_1340 1486-1359 257 µM -0.75127855460417 0.210035822983445 no 2704 0.226242516373553 3707 4309068 SGTC_423 5-fluorouracil 457 µM -0.755431655218223 0.208754091983744 no 2705 0.224995012828777 3730 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3182 9108849 49.47 µM -0.755493283001786 0.208735107173968 no 2706 0.224976530547648 3781 17133045 SGTC_3229 9132204 49.47 µM -0.755622288756787 0.208695369468927 no 2707 0.224937844279905 3764 17682924 SGTC_1162 k048-0130 20.1 µM -0.756227104468552 0.208509127256135 no 2708 0.224756522328222 3740 6797406 SGTC_266 formosanin C 406 nM -0.757493397572122 0.208119512416362 no 2709 0.22437715997942 3724 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_460 trequinsin 123 µM -0.75942185246759 0.207526988854169 no 2710 0.223800122739233 3809 5537 A vasodilator. SGTC_802 4112-3352 742 µM -0.759985519011621 0.207353989085751 no 2711 0.22363162042925 3854 704594 SGTC_2100 5377183 190 µM -0.760128495823507 0.20731012039816 no 2712 0.22358889045694 3802 2844202 SGTC_37 0566-0070 1.56 µM -0.760867394990863 0.207083496033375 no 2713 0.223368137471903 3783 1626686 SGTC_3280 9140961 49.47 µM -0.761847171282566 0.206783219481205 no 2714 0.223075611555591 3805 4901226 SGTC_2173 5763948 167 µM -0.762988019413019 0.206433903516673 no 2715 0.222735270442624 3776 2867177 SGTC_1519 esterone 74 µM -0.7633480357566 0.206323742830848 no 2716 0.222627930785265 3779 698 A steroid. SGTC_1745 st081495 74 µM -0.763816628916007 0.206180411136866 no 2717 0.222488262893629 3702 13842402 YBL026W LSM2 SGTC_660 4031-1742 102 µM -0.765968361759893 0.205523004620964 no 2718 0.221847563813808 3696 6738706 SGTC_1557 sumaresinolic acid 42.3 µM -0.767046213567909 0.205194163172324 no 2719 0.221527019667632 3736 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1299 1079-1439 3.74 µM -0.767803992831289 0.204963159823173 no 2720 0.221301821007533 3755 323161 SGTC_1267 0828-0272 9.49 µM -0.768244092635681 0.204829069683338 no 2721 0.22117109121668 3820 745334 SGTC_1597 7-benzyloxygramine 47.5 µM -0.769944322739069 0.204311531808671 no 2722 0.220666460280192 3766 260807 SGTC_3143 9086658 49.47 µM -0.772192141652443 0.203628508194918 no 2723 0.220000317571231 3867 25236626 SGTC_3159 9100096 49.47 µM -0.772264937787099 0.203606411103725 no 2724 0.219978763690809 3752 25236875 SGTC_2617 dihydrotanshinone i 20.83 µM -0.772536627471897 0.203523952983556 no 2725 0.219898331013214 3807 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_708 3448-5400 146 µM -0.772558750424018 0.203517239520193 no 2726 0.219891782342216 3756 3462195 SGTC_3085 9117376 49.47 µM -0.774052113630141 0.20306436680307 no 2727 0.219449986966294 3890 16480349 SGTC_510 ag-490 170 µM -0.774865314026196 0.202818011404582 no 2728 0.219209625025289 3909 5328779 SGTC_1240 0356-0016 42.1 µM -0.775152917073199 0.202730926115637 no 2729 0.219124652912212 3796 4305613 SGTC_1621 st003705 32.4 µM -0.775532982624732 0.202615877753287 no 2730 0.219012391873599 3827 24207032 SGTC_2634 4'-methoxyflavone 100 µM -0.776130454148898 0.202435098072031 no 2731 0.21883598190424 3817 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1630 st005209 31.3 µM -0.776758517622926 0.202245166062315 no 2732 0.21865062750296 3762 3367314 SGTC_40 0327-0103 19.753 µM -0.776841048034132 0.202220216054688 no 2733 0.218626277807042 3700 409036 SGTC_595 3909-8003 73.7 µM -0.77725826846637 0.202094113123527 no 2734 0.218503205373228 3874 699517 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.777683846729058 0.201965532569082 no 2735 0.218377708643119 3793 6857784 SGTC_2272 7805186 180 µM -0.778801643343804 0.201628044416344 no 2736 0.218048284773353 3783 2956062 YPR165W RHO1 SGTC_139 0099-0334 718.624 µM -0.781375723748105 0.200852156967438 no 2737 0.217290772449477 3845 97690 SGTC_772 k072-0172 35.3 µM -0.782735086799082 0.200443137391711 no 2738 0.21689134680254 3835 5861980 SGTC_2651 TUB2.036 5 µM -0.783346756928825 0.200259254917741 no 2739 0.2167117565194 3864 15992207 YFL037W TUB2 SGTC_2349 9023730 187.07 µM -0.784767094885316 0.199832658959853 no 2740 0.21629506802672 3778 4126287 SGTC_1347 1493-0251 600 nM -0.784910431759605 0.199789638370636 no 2741 0.216253042670808 3841 3986378 SGTC_3023 9089636 49.47 µM -0.78546564317269 0.19962305190024 no 2742 0.21609030324606 3885 17249241 SGTC_2261 9010538 184.68 µM -0.786000606872045 0.199462619677662 no 2743 0.215933565800643 3789 6457250 SGTC_1995 st072814 61.1 µM -0.787773857408169 0.198931388367901 no 2744 0.215414497610926 3784 5769371 SGTC_1154 4088-0362 150 µM -0.788249545076334 0.198789026794458 no 2745 0.215275376935904 3818 6618304 SGTC_2241 6772625 37.8075 µM -0.788359132839692 0.198756238589719 no 2746 0.215243334045795 3736 2285411 SGTC_1076 itraconazole 331 nM -0.789163968053035 0.198515535152139 no 2747 0.215008089259126 3812 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2433 5607874 27.82 µM -0.789877377349843 0.198302321707614 no 2748 0.214799692175216 3816 2252428 SGTC_78 0336-0123 156.75 µM -0.7900462251148 0.198251879165316 no 2749 0.214750386501865 3676 6765896 SGTC_738 1315-0003 72.4 µM -0.790904938639139 0.197995462075447 no 2750 0.214499733129065 3817 6251474 SGTC_3174 9107204 49.47 µM -0.791869998316971 0.197707528543885 no 2751 0.214218241043658 3844 3938802 SGTC_472 calcifediol 10 µM -0.793541129637901 0.197209531585467 no 2752 0.213731308070394 3857 5283731 A vitamin D metabolite. SGTC_3247 9135149 49.47 µM -0.793720831989131 0.197156025532803 no 2753 0.213678984953589 3809 8934436 YOR116C RPO31 SGTC_1360 1598-0022 39.8 µM -0.793767844476711 0.1971420290987 no 2754 0.213665297772756 3886 761525 SGTC_1180 1193-0155 285 µM -0.795532459588059 0.196617107452309 no 2755 0.213151918515318 3850 2921347 SGTC_1860 st056228 74.6 µM -0.796865750456603 0.196221054352187 no 2756 0.212764501979329 3801 688679 SGTC_2821 7996764 71.43 µM -0.799003572061037 0.195587026490585 no 2757 0.212144170373294 3854 2987135 SGTC_336 4111-0029 111 µM -0.799124770861251 0.195551119061541 no 2758 0.212109033824466 3813 3131175 SGTC_315 k915-0449 187 µM -0.800919839077583 0.195019765091119 no 2759 0.211589027029897 3860 20970215 YNL149C PGA2 SGTC_1703 st026983 48.3 µM -0.801290271283737 0.194910223672253 no 2760 0.211481810840398 3821 1104023 SGTC_803 4488-1585 147 µM -0.801870924888902 0.194738592475579 no 2761 0.211313813170664 3857 747204 SGTC_754 3474-0146 171 µM -0.802880514445134 0.194440394189076 no 2762 0.211021899765337 3804 24762078 SGTC_2732 terfenadine 20 µM -0.805786017398516 0.193583760110991 no 2763 0.210183120877463 3834 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_260 nsc-65238 3.989 µM -0.806246717921671 0.193448142764365 no 2764 0.21005030304897 3782 3246252 SGTC_3088 9117578 49.47 µM -0.80845401947161 0.192799179408983 no 2765 0.209414632695047 3891 678341 SGTC_2822 7994718 71.43 µM -0.809996354755072 0.192346511518585 no 2766 0.208971135403162 3814 1018011 SGTC_1505 k297-0037 20.6 µM -0.810248417731533 0.192272594101426 no 2767 0.20889870752459 3846 4089396 SGTC_3347 9188721 44.724 µM -0.811518024177414 0.191900546478235 no 2768 0.208534123191542 3892 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1849 st056239 19.2 µM -0.811627006053913 0.191868630795058 no 2769 0.208502845094088 3848 5393181 SGTC_414 piperonyl butoxide 100 µM -0.812867307112898 0.191505633721877 no 2770 0.208147070224529 3839 5794 A potent inhibitor of cytochrome P450. SGTC_524 r073-0010 27.8 µM -0.813313570367856 0.191375129511445 no 2771 0.208019149277877 3785 2772106 SGTC_3255 9139072 49.47 µM -0.81436916821457 0.191066649883958 no 2772 0.207716747921796 3849 17646060 SGTC_212 3807-4682 38.772 µM -0.815054957506694 0.190866403705096 no 2773 0.207520426344798 3934 3125501 YBL034C STU1 SGTC_3029 9088683 49.47 µM -0.816006851185274 0.190588670194324 no 2774 0.207248108624873 3846 25236615 SGTC_48 0382-0018 55 µM -0.816608360746791 0.190413296056879 no 2775 0.207076137800034 3904 762596 SGTC_2703 st077852 53.4 µM -0.82151410462325 0.188986696495344 no 2776 0.205676746685829 3890 6281836 SGTC_3138 9097216 49.47 µM -0.822289093525333 0.188761932006826 no 2777 0.205456191255335 3847 25237486 SGTC_160 3453-0671 289.699 µM -0.823865409228645 0.188305273054601 no 2778 0.205008018432962 3912 5322268 SGTC_1329 1447-1697 50.6 µM -0.82611977361062 0.187653368814517 no 2779 0.204368075917393 3885 2840515 SGTC_2165 5727197 32.143 µM -0.826365769621216 0.187582317560487 no 2780 0.204298317490723 3999 1361712 SGTC_2348 9022543 33.42 µM -0.827005635549806 0.187397582361111 no 2781 0.204116933640751 3917 3162678 YDL140C RPO21 SGTC_2947 9072639 7.68 µM -0.828043731492505 0.187098113801961 no 2782 0.20382286700569 3911 16488146 SGTC_2868 9035608 32.47 µM -0.828763586556567 0.186890624855763 no 2783 0.203619098404791 3848 6462614 SGTC_1276 0871-0068 94.2 µM -0.829393570669736 0.186709156935374 no 2784 0.203440869194756 3872 3414906 SGTC_1610 st001799 48.1 µM -0.83090007100982 0.186275649625582 no 2785 0.203015041773554 3780 621897 SGTC_1929 genistein trimethyl ether 50.5 µM -0.831387043075235 0.186135653077699 no 2786 0.202877508150513 3820 136420 SGTC_3239 9133757 49.47 µM -0.8320095455372 0.18595678873725 no 2787 0.202701778274836 3879 17036923 SGTC_1530 rhein 70.4 µM -0.835056200527399 0.185082927920903 no 2788 0.201843032977996 3931 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1394 3474-0001 65.7 µM -0.835349372553141 0.184998973229049 no 2789 0.201760513102973 3875 5017666 YIL048W NEO1 SGTC_15 0266-0086 27.098 µM -0.835564587669581 0.184937357859062 no 2790 0.201699948818579 3952 1712902 YIL048W NEO1 SGTC_3102 9121669 49.47 µM -0.838186643911087 0.184187696333622 no 2791 0.200962943508799 3893 41905072 SGTC_569 4130-2812 160 µM -0.840121415657884 0.183635748027661 no 2792 0.200420156868007 3719 743552 SGTC_2279 7948423 32.93 µM -0.840306086837876 0.183583119291381 no 2793 0.200368394741639 3820 1247112 SGTC_489 paxilline 115 µM -0.840613146494369 0.183495632339803 no 2794 0.200282345704628 3854 105008 A toxic potassium channel blocker. SGTC_209 4077-0173 175.592 µM -0.841613178483801 0.183210884984742 no 2795 0.200002255125861 3850 15993494 SGTC_1178 0988-0033 191 µM -0.842576693897668 0.182936796122407 no 2796 0.199732615054598 3955 5392207 SGTC_2489 cantharidin 73.42 µM -0.842590811243511 0.182932782098744 no 2797 0.199728665937558 3847 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_317 4495-0002 170 µM -0.843351757597198 0.182716501466902 no 2798 0.199515872051204 3928 15991618 SGTC_174 3553-0389 74.3 µM -0.846606476463761 0.18179322906975 no 2799 0.198607251412744 3929 738071 SGTC_1039 k821-0043 94 µM -0.847969608562131 0.181407415381062 no 2800 0.198227448192995 3887 15992768 SGTC_1560 lithocholic acid 53.1 µM -0.847974011788132 0.181406169946497 no 2801 0.198226222053237 3769 9903 A bile acid which acts as a detergent. SGTC_366 0181-0206 4.31 µM -0.850237639143028 0.180766621007923 no 2802 0.197596489704597 3870 274874 SGTC_3007 9078383 71.4286 µM -0.851543291128556 0.18039837511217 no 2803 0.197233812949354 3902 6496995 SGTC_1077 5-fluorocytosine 377 nM -0.851767333404289 0.180335233603409 no 2804 0.197171620235905 3923 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3353 9151644 39.2805 µM -0.855473184927984 0.179292831314259 no 2805 0.196144621601347 3972 4909158 SGTC_168 3970-0862 530.542 µM -0.855905497705703 0.179171475275748 no 2806 0.196025026881865 3901 3135186 SGTC_290 2043-6722 48.1 µM -0.85752954358916 0.178716045422557 no 2807 0.195576147256811 3939 773758 YLR208W SEC13 SGTC_1816 st051957 91.6 µM -0.857538183011549 0.178713624627048 no 2808 0.195573761026057 3894 674121 SGTC_777 1315-0167 517 µM -0.858117446519231 0.17855136012418 no 2809 0.195413807283324 3959 4221767 SGTC_1761 st044296 37 µM -0.85862772997314 0.178408495358138 no 2810 0.195272967060398 3913 1826700 SGTC_2724 maprotiline 69.64 µM -0.859839558532675 0.178069506725848 no 2811 0.194938744898525 3836 4011 A tricyclic antidepressant. SGTC_1130 3454-2858 15.9 µM -0.860329399616167 0.177932597254378 no 2812 0.194803745566871 3969 715628 YIL048W NEO1 SGTC_2481 5478948 45.16 µM -0.860904153319468 0.177772039563978 no 2813 0.194645416993466 3972 77792 SGTC_1325 1431-0015 227 µM -0.861511760119563 0.177602403762784 no 2814 0.194478123477076 3888 1103340 SGTC_2447 5741742 33.78 µM -0.86324986378337 0.177117712446061 no 2815 0.194000051619128 3971 1776504 SGTC_3070 9117005 49.47 µM -0.863466051702741 0.177057484302935 no 2816 0.193940638443645 3951 8779016 SGTC_823 0417-1665 178 µM -0.863747775990215 0.176979017696567 no 2817 0.193863231080758 3935 3429856 SGTC_936 3005-4620 401 µM -0.864465016015475 0.176779349275475 no 2818 0.193666245195566 3902 777207 SGTC_1697 st025554 27.742 µM -0.864680113899416 0.176719497151426 no 2819 0.193607193585705 3892 1269519 SGTC_1289 0976-0073 69.1 µM -0.865751704543101 0.176421512316565 no 2820 0.193313169532843 3977 3391136 SGTC_1228 0124-0032 52.5 µM -0.867571055075908 0.175916321018281 no 2821 0.19281459887258 4000 X1228 SGTC_1366 1683-0113 21.9 µM -0.867816195923198 0.175848321214647 no 2822 0.192747481139694 3925 708623 SGTC_2327 6189656 200 µM -0.8681794638491 0.175747584671031 no 2823 0.19264804734935 4012 5349088 SGTC_2987 9018338 71.43 µM -0.870836905762941 0.175011771130433 no 2824 0.191921605523098 3965 5055682 SGTC_204 PMA1.184 62.41 µM -0.8746009258363 0.173972909668194 no 2825 0.190895541928587 3965 2252213 YGL008C PMA1 SGTC_1137 ixabepilone 100 µM -0.874888482898752 0.173893706072438 no 2826 0.190817293117486 3891 154225 A novel microtubule stabilizer. SGTC_313 3474-0040 5.03 µM -0.874944238465469 0.173878351631094 no 2827 0.190802123426783 3936 1043375 YIL048W NEO1 SGTC_391 gliotoxin 8.33 µM -0.875451410262372 0.173738721949531 no 2828 0.190664168688968 4037 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3254 9136651 49.47 µM -0.875770526782808 0.173650902415027 no 2829 0.190577397860674 3922 16454030 SGTC_998 3996-0085 177 µM -0.876131527755252 0.173551590506982 no 2830 0.19047926747931 3967 715391 SGTC_393 acivicin 6.25 µM -0.876814516484636 0.173363798185021 no 2831 0.190293696519636 3794 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3051 9093778 49.47 µM -0.878669171864867 0.172854501159894 no 2832 0.18979033922748 3974 17217378 SGTC_656 4090-1979 187 µM -0.881090047729089 0.172191153483757 no 2833 0.189134541742855 3984 22330961 SGTC_1690 st023502 41.2 µM -0.883584749337348 0.171509278659192 no 2834 0.188460207314685 3940 24207482 SGTC_2005 4024620 188 µM -0.883622334430164 0.17149901876735 no 2835 0.18845005916531 3933 236743 SGTC_499 genistein 192 µM -0.887796374227112 0.170362039948993 no 2836 0.187325146813336 3978 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2939 9044578 71.43 µM -0.887844844040437 0.170348865538018 no 2837 0.187312108529395 3909 2653634 SGTC_1337 1486-1011 40.3 µM -0.888035783368348 0.170296973334199 no 2838 0.187260751686427 3939 X1337 SGTC_1315 1237-0019 3.69 µM -0.888056415331349 0.170291366724627 no 2839 0.18725520284028 3980 825140 SGTC_2323 6148992 148.28 µM -0.891662126520444 0.169313353159755 no 2840 0.186287029732343 3939 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_667 1498-1044 59 µM -0.892587692110165 0.169062885318492 no 2841 0.186039006348453 3965 6739982 SGTC_2081 5214970 32.255 µM -0.894691199280478 0.168494539449185 no 2842 0.185476092264789 3876 2063512 SGTC_3032 9089427 49.47 µM -0.894745831270748 0.168479794836496 no 2843 0.185461486439091 3982 17173707 SGTC_639 0833-0042 114 µM -0.896400115145558 0.168033713553452 no 2844 0.185019552921012 3959 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1256 0570-0116 285 µM -0.898877573323231 0.167367084421312 no 2845 0.184358937368966 3979 410638 SGTC_3223 9129970 49.47 µM -0.900138841744475 0.167028360609974 no 2846 0.184023183914707 3995 17248386 SGTC_620 0109-0052 432 µM -0.90382053556318 0.16604214258854 no 2847 0.183045285411968 3970 493037 SGTC_3146 9095609 49.47 µM -0.906988498497493 0.165196555980753 no 2848 0.18220643971667 4029 17173999 SGTC_731 3966-0296 387 µM -0.908814191353454 0.164710513735131 no 2849 0.181724107145693 3980 660956 SGTC_1717 st033143 58.0435 µM -0.913522318654057 0.163461379758599 no 2850 0.180483950444239 4029 674616 SGTC_1053 3366-3204 134 µM -0.913739350237282 0.163403946887834 no 2851 0.180426910961743 4024 3632071 YPR165W RHO1 SGTC_3289 9119912 71.43 µM -0.914092054383282 0.16331063907307 no 2852 0.180334238616506 4029 17014829 SGTC_2929 9013348 24.6 µM -0.914629765380912 0.163168454357691 no 2853 0.180193013559797 4009 2995952 SGTC_2762 leflunomide 42.06 µM -0.915767494025391 0.162867874704229 no 2854 0.17989442805833 3958 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_509 pifithrin 175 µM -0.916890989096586 0.162571409006539 no 2855 0.179599883137645 4023 4817 A p53 inhibitor. SGTC_1653 st012112 65 µM -0.918623991726201 0.162114796589377 no 2856 0.179146139280031 3977 720429 SGTC_504 lovastatin 124 µM -0.918760450649979 0.162078877827418 no 2857 0.179110441538917 4011 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3113 9123498 49.47 µM -0.921368567449126 0.161393364785244 no 2858 0.17842901682092 4063 8897275 SGTC_2064 5220758 200 µM -0.921693404227633 0.161308117840221 no 2859 0.178344260983381 4063 788518 SGTC_1123 mangostin 811.285 nM -0.921953165831058 0.161239969716367 no 2860 0.178276502702288 4021 5281650 An antioxidant. SGTC_1865 st057639 52.2 µM -0.92443820987388 0.160588971037912 no 2861 0.177629104249504 3982 688818 SGTC_1296 1068-0102 11.9 µM -0.927139449571791 0.15988328640707 no 2862 0.176927068001016 4013 767053 SGTC_1328 1441-0025 69.2 µM -0.928563394905412 0.159512105884679 no 2863 0.176557699783442 3966 4562601 SGTC_1655 st012546 55.1 µM -0.928784906191185 0.159454415168973 no 2864 0.176500284118911 3997 720985 YLR208W SEC13 SGTC_398 bronopol 33.3 µM -0.929761122534543 0.159200330756553 no 2865 0.176247389843184 3907 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2152 5568786 200 µM -0.930264226684496 0.159069489082146 no 2866 0.176117147501203 3982 5399883 SGTC_3037 9091026 49.47 µM -0.931931992583591 0.158636259269436 no 2867 0.175685836318465 3973 25236398 YIL048W NEO1 SGTC_2093 5331342 194.4 µM -0.932336298250616 0.158531350798357 no 2868 0.175581377216421 4093 33839 SGTC_2760 etidronate 98.04 µM -0.933853825358202 0.158137991721226 no 2869 0.175189650030469 3973 3305 A chelator and antioxidant. SGTC_2254 7938975 95.19 µM -0.934970044079946 0.157849065270269 no 2870 0.174901868752733 4101 2969277 SGTC_3050 9093513 49.47 µM -0.935139380830265 0.157805263782998 no 2871 0.17485823691327 3992 25236664 SGTC_1710 st031758 61.5 µM -0.93615583134754 0.157542511413963 no 2872 0.174596480279744 4037 5394341 SGTC_1111 tnp00062 510.699 nM -0.936738428553522 0.157392039771612 no 2873 0.174446561916606 4065 676306 SGTC_3046 9092212 49.47 µM -0.939223564689335 0.156751246731713 no 2874 0.173807986374116 4068 25236637 SGTC_1152 3909-8331 15.9 µM -0.939571126166056 0.156661764957483 no 2875 0.173718796337101 3989 16001939 SGTC_311 1315-0136 58 µM -0.942897491934603 0.155807073351157 no 2876 0.172866668952458 4078 6759207 SGTC_1737 st035557 69.7 µM -0.944387225133758 0.155425293154644 no 2877 0.172485903594058 3904 5716916 SGTC_1617 st002906 78 µM -0.944736337949799 0.155335913895738 no 2878 0.172396750227025 4016 5150859 SGTC_1377 2944-0135 198 µM -0.947476042806493 0.154635677190786 no 2879 0.171698129187021 4073 1894137 SGTC_308 4092-1169 104 µM -0.948031168673173 0.154494048027741 no 2880 0.171556793489843 3961 2268590 YDL196W YDL196W SGTC_221 trifluoperazine 10.304 µM -0.94818734637044 0.154454217899847 no 2881 0.171517043867962 3996 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_984 1492-0255 2.91 µM -0.948371020405972 0.154407384044961 no 2882 0.171470303537357 3990 1585198 SGTC_2452 5863136 48.41 µM -0.950722654158927 0.153808585851257 no 2883 0.170872592497846 3996 2184096 SGTC_422 cantharidin 155 µM -0.950763641362784 0.153798162896671 no 2884 0.170862186679384 3958 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2698 st077697 67.5 µM -0.950935562536761 0.153754448818729 no 2885 0.170818543803243 4010 3154499 SGTC_2133 5320837 200 µM -0.952879303356116 0.153260789659902 no 2886 0.170325613779488 4076 2841355 SGTC_2229 7354935 190 µM -0.954943897107072 0.152737588473636 no 2887 0.169803034587723 3958 318112 SGTC_2919 7978188 46.38 µM -0.956368236005351 0.152377329512635 no 2888 0.169443113338733 4038 2980291 SGTC_1059 3448-6867 171 µM -0.957960517269743 0.151975260980107 no 2889 0.169041334148213 3952 3934407 SGTC_2332 7982454 138.89 µM -0.960578459948752 0.151315734806938 no 2890 0.168382081712833 3975 2981748 SGTC_3318 9139014 38.6185 µM -0.964664239068663 0.150290232592767 no 2891 0.167356506209537 4041 16643984 SGTC_2722 naftopidil 47.16 µM -0.965726687809901 0.150024325884565 no 2892 0.167090480760214 3957 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_146 3448-8650 53.125 µM -0.969038705407376 0.149197417501852 no 2893 0.166262938955427 4041 2891488 YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM -0.970724916926108 0.148777594093842 no 2894 0.165842640241299 4148 651118 SGTC_2228 7354201 200 µM -0.970760638256155 0.148768708947504 no 2895 0.165833743912587 4080 753451 SGTC_200 k038-0079 37.545 µM -0.970872651469691 0.148740849636424 no 2896 0.165805849237036 4018 3436683 SGTC_677 0929-0063 136 µM -0.971123293552761 0.148678523946208 no 2897 0.165743442770965 4026 1539583 SGTC_2306 7482397 179.52 µM -0.971980178932979 0.148465579185506 no 2898 0.165530204700925 4068 891448 SGTC_52 0329-0193 875 nM -0.972479641288117 0.148341551828556 no 2899 0.16540599414002 4168 3739292 SGTC_188 3229-0966 278.469 µM -0.974484057741968 0.147844508985609 no 2900 0.164908125506415 4093 5722370 SGTC_951 1171-0579 82.7 µM -0.975125643185804 0.147685648429053 no 2901 0.164748970026312 4007 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1460 k062-0059 9.15 µM -0.975573249951943 0.147574885927447 no 2902 0.164637992991343 3948 1373085 SGTC_3120 9124077 49.47 µM -0.981595377378937 0.146090091816985 no 2903 0.163149612867483 4171 18774327 YGL155W CDC43 SGTC_2449 5812982 45.77 µM -0.983724385635279 0.145567580573197 no 2904 0.162625523204701 4001 776185 SGTC_1545 lovastatin 49.4 µM -0.983896229881733 0.145525460626427 no 2905 0.16258326879886 4134 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3322 9139058 2.11 µM -0.987692340905538 0.144597103608442 no 2906 0.16165167333372 4158 4908926 YPR165W RHO1 SGTC_854 0422-0053 192 µM -0.989020647607724 0.144273204212573 no 2907 0.161326519814043 4089 3596728 SGTC_2516 gossypol 71.55 µM -0.989377502564546 0.144186270742052 no 2908 0.161239238754816 4122 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_605 1315-0399 119 µM -0.990083917273466 0.144014285156163 no 2909 0.161066551790829 4162 24020461 SGTC_1003 4049-0218 100 µM -0.991036054386425 0.14378269433871 no 2910 0.160833987670362 4117 295161 SGTC_1720 st037298 9.481 µM -0.991455792011714 0.143680680296713 no 2911 0.160731534374878 4097 597396 SGTC_2033 5192550 145 µM -0.994285801548061 0.142994142992163 no 2912 0.160041873071182 4077 182073 SGTC_832 4083-0019 164 µM -0.994333241916734 0.142982653266578 no 2913 0.160030328569482 4157 1990758 SGTC_1743 st037606 46.3785 µM -0.994836745571528 0.142860746648468 no 2914 0.159907835704566 4054 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1859 st055998 20 µM -0.994850200451311 0.142857489962038 no 2915 0.159904563229668 4018 676301 SGTC_641 4092-0595 30 µM -0.994944435794724 0.14283468217438 no 2916 0.159881644684015 4113 786260 SGTC_2333 9017922 200 µM -0.997351911458191 0.142252835233415 no 2917 0.159296862227996 4142 3163164 SGTC_588 3970-1144 52.9 µM -0.99873458544373 0.141919391912773 no 2918 0.158961640939118 3967 1888707 SGTC_2137 5261020 140 µM -0.999090958547024 0.141833535423555 no 2919 0.158875315327462 4049 763655 SGTC_2673 kobusone 100 µM -0.999688003763837 0.141689775668695 no 2920 0.158730759663683 4148 6710676 An epoxy ketone and protein crosslinker. SGTC_2497 7-hydroxyflavone 100 µM -0.999745356313665 0.141675971211496 no 2921 0.158716878093837 4115 5281894 SGTC_954 1189-0853 2.85 µM -1.00380550866567 0.140701028631887 no 2922 0.157736184335693 4034 2828194 SGTC_516 3992-2719 87.3 µM -1.00408040794949 0.140635183509638 no 2923 0.157669929031499 4019 5350887 YDR037W KRS1 SGTC_867 0518-0118 155 µM -1.00738882673761 0.139844376476023 no 2924 0.156873979279283 4071 6848158 SGTC_2571 chrysanthemic acid 100 µM -1.00944483306138 0.139354457645784 no 2925 0.15638067315618 4123 2743 An insecticide. SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.01142342251509 0.138884090027877 no 2926 0.15590690770068 4158 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1487 3970-0795 2.82 µM -1.01189584113758 0.138771942599379 no 2927 0.155793928993802 4141 3765103 SGTC_783 0848-0141 92.7 µM -1.01492868604737 0.138053444839862 no 2928 0.155069911437399 4031 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2558 carylophyllene oxide 100 µM -1.01517657956507 0.137994829855232 no 2929 0.155010831297062 4230 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2990 9074105 71.4286 µM -1.01815907834368 0.137290941876811 no 2930 0.15430118158394 4021 6502001 SGTC_2417 cerulenin 830 nM -1.01866515318353 0.137171748885603 no 2931 0.154180980695718 4140 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2397 5161689 200 µM -1.02015529929238 0.136821193663962 no 2932 0.15382740686513 4187 2259942 SGTC_1600 coumarin 106 71.1 µM -1.02062218722399 0.136711484897732 no 2933 0.153716736718276 4181 100336 A hepatotoxic, DNA x-linker. SGTC_521 r062-0005 13.8 µM -1.02121190873034 0.136572998826459 no 2934 0.153577025710316 4024 2832033 SGTC_1100 amiodarone 5.07 µM -1.02369278914846 0.135991457151931 no 2935 0.152990201174102 4206 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2097 5376186 200 µM -1.02770820459388 0.135053802968549 no 2936 0.152043553630856 4088 742755 SGTC_3008 9078912 71.4286 µM -1.03459060939981 0.133457000348213 no 2937 0.150430070675786 4127 16648731 SGTC_2658 polymyxin b sulfate 77.05 µM -1.03510031390483 0.133339261264109 no 2938 0.150311032998518 4153 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_296 1222-0039 74.9 µM -1.03541941464713 0.133265587039492 no 2939 0.150236541363808 4135 5984176 SGTC_335 4077-0256 27.6 µM -1.03546147796373 0.133255877518436 no 2940 0.150226723839052 4109 3121989 SGTC_1244 0416-0015 52.5 µM -1.03680756473761 0.132945415857413 no 2941 0.149912774674877 4095 96201 SGTC_172 1112-0046 2.638 µM -1.03717082427083 0.132861719017476 no 2942 0.149828126316206 4115 2802135 YIL048W NEO1 SGTC_533 1222-0222 6.71 µM -1.03832968742515 0.132594953598677 no 2943 0.149558295963417 4170 3982874 SGTC_666 0272-0154 136 µM -1.03913250349764 0.13241036521764 no 2944 0.149371558076037 4142 6870312 SGTC_1443 4112-3303 14 µM -1.03939633095168 0.132349743074973 no 2945 0.14931022486292 4167 704433 SGTC_1934 st074720 32.6 µM -1.04078633889218 0.132030663643016 no 2946 0.14898736085076 4089 17250992 SGTC_980 1473-0395 201 µM -1.04132291296035 0.131907633900288 no 2947 0.14886285300758 4017 768876 SGTC_1062 mesoridazine 14.2 µM -1.04156249899444 0.131852725355914 no 2948 0.148807281390419 4160 4078 A neuroleptic. SGTC_3307 9126885 69.2785 µM -1.04241930538395 0.131656490722657 no 2949 0.14860865990586 4106 24824909 SGTC_3077 9117319 49.47 µM -1.0440723891465 0.131278454206723 no 2950 0.148225949609142 4119 17154678 SGTC_482 fipronil 114 µM -1.04418683467414 0.131252309931243 no 2951 0.148199478415424 4234 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1254 0550-0035 264 µM -1.04450979064089 0.131178552304532 no 2952 0.148124795918268 4192 15121435 SGTC_1462 k081-0014 26.5 µM -1.04559870185286 0.130930074599202 no 2953 0.147873174444394 3701 3270634 SGTC_2756 carbadox 75.1 µM -1.04659863831697 0.130702186595906 no 2954 0.147642365105254 4098 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2190 6049624 200 µM -1.04713241574086 0.130580649714936 no 2955 0.147519255298498 4014 2265554 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.04856478502236 0.13025489689359 no 2956 0.147189235277297 4108 688761 SGTC_402 epigallocatechin gallate 10 µM -1.04903716299285 0.13014759096475 no 2957 0.147080507296259 4091 65064 An antioxidant. SGTC_3057 9095946 49.47 µM -1.05053083644147 0.129808688973263 no 2958 0.146737060566172 4170 24540043 SGTC_463 ikarugamyin 104 µM -1.050870810161 0.129731637233123 no 2959 0.146658964188404 4255 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2700 st077718 96.8 µM -1.05355437054261 0.129124546080829 no 2960 0.146043494606827 4137 904970 SGTC_1464 k208-0027 110 µM -1.05393391864251 0.129038841677668 no 2961 0.145956586228541 4156 X1464 SGTC_1688 st021091 57.6 µM -1.05917213823185 0.127860045845426 no 2962 0.144760695704347 4176 3656366 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.06043614175661 0.127576721915441 no 2963 0.144473113591115 4196 61125 An anti-inflammatory. SGTC_1211 1056-0033 32.3 µM -1.06175471221864 0.127281632393896 no 2964 0.144173527097647 4204 6741922 SGTC_994 3910-0338 138 µM -1.06739343947371 0.126025071605482 no 2965 0.142897104859298 4229 3479481 SGTC_918 glabranin 770.725 nM -1.06944512574007 0.125570017350134 no 2966 0.142434571393479 4172 124049 Also referred to as licorice root. SGTC_1836 st055642 81 µM -1.0711452736671 0.125193802327813 no 2967 0.142052057062482 4172 8571 SGTC_3078 9116413 49.47 µM -1.07308348744975 0.124765868164927 no 2968 0.141616829526735 4097 17177322 SGTC_5 0352-0601 109.883 µM -1.07662660348652 0.123986235539899 no 2969 0.140823557086558 4089 762456 SGTC_860 0443-0016 25.1 µM -1.07770520945663 0.123749575798894 no 2970 0.140582666460311 4190 5337942 SGTC_288 1315-0019 35.1 µM -1.07873553517561 0.12352380486286 no 2971 0.140352819855321 4229 6811474 SGTC_2735 sertaconazole 140 nM -1.08128858348161 0.122965609717087 no 2972 0.139784382095279 4307 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_721 1187-1332 279 µM -1.08870742272005 0.121353608812497 no 2973 0.138141463735789 4133 25730 SGTC_2242 6630449 61.2675 µM -1.08873186390391 0.121348322788274 no 2974 0.13813607303276 4231 691249 YDR170C SEC7 SGTC_484 loperamide 105 µM -1.08898174878503 0.121294288151341 no 2975 0.138080967108362 4188 3955 An opioid-receptor agonist. SGTC_1943 st076331 65.2 µM -1.08898198742199 0.121294236557022 no 2976 0.138080914490055 4194 24208415 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.08942499227175 0.121198483641558 no 2977 0.137983257614533 4162 6708739 YPR165W RHO1 SGTC_2709 st078560 56 µM -1.09092069579138 0.120875588859527 no 2978 0.137653889825471 4186 17250903 SGTC_804 1595-0054 20.9 µM -1.09503728009439 0.119990021866705 no 2979 0.136750152168344 4129 761523 Stimulates phospholipase C. SGTC_129 0088-0017 176.636 µM -1.09705342992963 0.119557976454062 no 2980 0.136309018143612 4055 182446 SGTC_1984 st072354 53.1 µM -1.09786125071677 0.119385174970886 no 2981 0.136132540288578 4071 5762938 SGTC_1792 st045773 43.6 µM -1.10141591099013 0.118626889368424 no 2982 0.135357841845978 4154 2919270 SGTC_1432 4049-0298 68.4 µM -1.10353892363369 0.118175631575775 no 2983 0.134896598994715 4224 741646 SGTC_1164 k060-0068 93.7 µM -1.10427995130811 0.118018408311268 no 2984 0.134735858469426 4193 5963676 SGTC_2450 5739737 12.93 µM -1.10435352437174 0.118002806449841 no 2985 0.134719906493349 4225 2262825 SGTC_2468 5987765 72.9 µM -1.104867601216 0.117893832323177 no 2986 0.134608481464446 4233 26772094 SGTC_1658 st012944 20 µM -1.10500259193268 0.117865228767147 no 2987 0.134579233011137 4047 24207260 SGTC_455 paf C-16 10 µM -1.10730302843647 0.117378537610045 no 2988 0.134081467719238 4178 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1356 1502-0781 85.8 µM -1.10733943205641 0.117370847344939 no 2989 0.134073600933716 4191 567702 SGTC_276 colchicine 750 µM -1.10761599557147 0.11731243495151 no 2990 0.134013846193031 4265 2833 A microtubule depolymerizer. SGTC_71 0417-1750 47.813 µM -1.10774376143785 0.117285456747911 no 2991 0.133986247082905 4207 6811472 SGTC_1056 3448-1962 115 µM -1.10846446291509 0.117133360447255 no 2992 0.133830639223361 4200 715507 SGTC_2176 5809774 33.9695 µM -1.10915930838882 0.116986853138028 no 2993 0.133680731630988 4147 2870539 SGTC_1134 3477-0009 42.5 µM -1.10951808606908 0.116911256165494 no 2994 0.133603373304582 4281 3973534 SGTC_1696 st025591 34.7925 µM -1.11110675067701 0.116576929497306 no 2995 0.133261201237324 4209 2787147 SGTC_1629 st005085 44.9 µM -1.11215340297874 0.116357037488309 no 2996 0.133036099418177 4157 24207091 SGTC_1500 4488-1866 171 µM -1.11444610024896 0.115876391578878 no 2997 0.132543927736831 4267 2900003 SGTC_3066 9117245 49.47 µM -1.11444913341618 0.115875756634471 no 2998 0.132543277441015 4261 17176980 SGTC_320 4092-0846 5.34 µM -1.11565700528532 0.115623104575762 no 2999 0.132284490497274 4161 1359356 SGTC_2815 7968870 71.43 µM -1.11781881850712 0.11517189289422 no 3000 0.131822191280845 4169 2977326 YHR190W ERG9 SGTC_2544 sphondin 68.51 µM -1.11852898087625 0.115023941983675 no 3001 0.13167056805445 4205 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2375 9072683 200 µM -1.11955898584667 0.114809597267143 no 3002 0.131450870759585 4287 16798029 SGTC_870 0573-2213 57.6 µM -1.12044876124069 0.114624663308681 no 3003 0.131261287896451 4209 3916321 SGTC_856 0433-0016 11.3 µM -1.12114196184941 0.114480733112308 no 3004 0.131113719793127 4250 3911780 SGTC_1144 3486-0183 12.5 µM -1.12484778370746 0.113713470349022 no 3005 0.130326770975729 4212 6744069 SGTC_2044 5102272 200 µM -1.1288878986966 0.112881178900721 no 3006 0.129472563151782 4215 592666 SGTC_480 am 92016 50 µM -1.12889248412795 0.11288023674752 no 3007 0.129471595855935 4210 2129 K+ channel blocker. SGTC_2684 capsaicin 100 µM -1.13003297601467 0.112646078007512 no 3008 0.129231164799615 4245 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_210 3551-0445 56.827 µM -1.1303765343745 0.112575608765956 no 3009 0.129158798763952 4264 2865180 YOR207C RET1 SGTC_1676 st018489 23.4 µM -1.13158725559913 0.112327521750591 no 3010 0.128904000279704 4246 3696235 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.13203700040589 0.112235464823905 no 3011 0.128809439533172 4197 16623 A steroid. SGTC_2872 9044037 25.97 µM -1.1325127822346 0.112138137161291 no 3012 0.128709456784202 4238 6465195 SGTC_441 propafenone 146 µM -1.13416929049613 0.111799746517238 no 3013 0.128361771485683 4209 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2023 5144124 124 µM -1.13481560065914 0.111667916880463 no 3014 0.128226294140202 4214 2830192 SGTC_920 mycophenolic acid 780.421 nM -1.13509102210958 0.11161177222615 no 3015 0.128168591413453 4214 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2893 9048488 25.97 µM -1.13556375049342 0.111515453646828 no 3016 0.128069593545444 4274 6467338 SGTC_2458 5808907 16.39 µM -1.13591584507724 0.111443752907441 no 3017 0.127995893098194 4374 2731747 SGTC_1380 2291-0730 164 µM -1.13645376533865 0.111334274241139 no 3018 0.127883352520109 4239 2999191 SGTC_3263 9137018 49.47 µM -1.1377338204272 0.111074064353005 no 3019 0.127615823316217 4198 43844957 SGTC_1677 st019204 53.9 µM -1.14020642124844 0.110572667292809 no 3020 0.12710015646791 4258 3945625 SGTC_786 4544-0069 423 µM -1.14161718837024 0.110287318117328 no 3021 0.126806588111783 4224 748821 YLR208W SEC13 SGTC_2767 sibutramine 71.45 µM -1.14219631271083 0.110170334402399 no 3022 0.126686214159936 4268 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_788 1182-0090 188 µM -1.14380643781624 0.109845555279148 no 3023 0.126351959690257 4254 5715185 SGTC_2537 larixol 68.93 µM -1.14532653889909 0.109539566087001 no 3024 0.126036958194574 4217 6708759 SGTC_479 n-linoleoylglycine 10 µM -1.14534251570275 0.109536353285351 no 3025 0.126033650326894 4276 6433346 An anti-infammatory. SGTC_2408 sulbentine 18.36 µM -1.14572655982272 0.109459145585268 no 3026 0.125954155319323 4145 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_827 3253-0474 693 µM -1.14914451097266 0.108773726806136 no 3027 0.125248198524465 4268 5402065 SGTC_1413 3910-0535 34.4 µM -1.15036095121758 0.108530534193158 no 3028 0.124997618117267 4264 2876951 SGTC_1045 1348-1485 165 µM -1.15037636568671 0.108527455020346 no 3029 0.12499444506475 4220 6810614 SGTC_2546 rhodinyl acetate 100 µM -1.15113943354402 0.108375104203061 no 3030 0.124837438665338 4191 6708682 SGTC_1387 3342-1166 1.8 µM -1.15237852648032 0.108128040237698 no 3031 0.12458278052958 4210 3418228 SGTC_1393 3470-5649 58.2 µM -1.15366186421293 0.107872581971193 no 3032 0.1243194122723 4217 4108395 SGTC_1287 0971-0001 34.6 µM -1.15793252000209 0.107025605695824 no 3033 0.123445787621206 4239 4665869 SGTC_1108 betulinic acid 729.144 nM -1.15851544676423 0.106910370034364 no 3034 0.123326875870196 4242 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_360 0957-0399 1.01 µM -1.16080377688425 0.106458867767491 no 3035 0.122860853349936 4267 6752301 YPR165W RHO1 SGTC_906 1165-0455 526 µM -1.16542349475731 0.105551566201383 no 3036 0.121923805796759 4241 3252859 SGTC_1975 st070967 30.8 µM -1.16803189127834 0.105041759990645 no 3037 0.121396950587191 4248 261391 SGTC_2059 5238311 157 µM -1.16817622626416 0.105013602117688 no 3038 0.121367843991357 4216 703021 SGTC_1699 st031318 29.054 µM -1.17074435335888 0.104513507191427 no 3039 0.12085077565811 4305 5340658 SGTC_134 0269-0018 6.916 µM -1.17127765084117 0.104409874144366 no 3040 0.12074359589174 4224 4378915 SGTC_1266 0828-0227 32.9 µM -1.17390856944356 0.103899710511372 no 3041 0.120215824818316 4245 3913820 SGTC_1184 1269-1718 139 µM -1.17413211499168 0.103856446085642 no 3042 0.120171055870338 4308 5403821 SGTC_1496 4469-0713 57.4 µM -1.17543051164793 0.103605416103806 no 3043 0.119911261257725 4239 746691 SGTC_1809 st050081 57.6 µM -1.17919614772994 0.102879864691092 no 3044 0.119160039847529 4341 5036894 SGTC_1981 st071826 47 µM -1.18397174236456 0.101965036466846 no 3045 0.118212124398389 4302 11838600 SGTC_2438 5259590 200 µM -1.18669509079885 0.101446001043202 no 3046 0.117673956073957 4292 1201127 SGTC_2419 paclitaxel 166.5 µM -1.18710884508953 0.101367313461838 no 3047 0.117592344945908 4192 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1833 st055984 71 µM -1.18758463412772 0.101276883117313 no 3048 0.117498547287733 4273 676288 SGTC_676 falcarinol 140 µM -1.1876990970773 0.101255136610892 no 3049 0.117475989822747 4306 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1951 sophoraflavanone G 9.2 µM -1.18830185326348 0.101140676722824 no 3050 0.117357253923961 4238 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3020 9089140 49.47 µM -1.19037662069073 0.100747411411221 no 3051 0.116949198922031 4291 17217859 SGTC_2992 9074591 71.4286 µM -1.19077828073076 0.100671407093156 no 3052 0.116870318725975 4235 17741321 SGTC_2295 7971645 200 µM -1.19160826949309 0.100514484577007 no 3053 0.116707440485484 4329 2978226 YKL099C UTP11 SGTC_2147 5545932 89.7195 µM -1.19521412350881 0.0998348124299534 no 3054 0.116001690904167 4316 797404 SGTC_1107 amlodipine 47 µM -1.19686326051017 0.0995250856463861 no 3055 0.115679928100418 3942 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_875 0709-0210 25.7 µM -1.20299415224524 0.098379792512345 no 3056 0.114489291746418 4282 6251364 SGTC_2087 5276107 200 µM -1.20339048522862 0.0983060882675758 no 3057 0.114412624060341 4237 144405 SGTC_2984 9022109 38.96 µM -1.20352211498228 0.0982816186284986 no 3058 0.114387169344629 4313 6459207 SGTC_3206 9114350 49.47 µM -1.20418356265401 0.0981587247059756 no 3059 0.114259318856315 4150 17087243 SGTC_2677 mitomycin C 100 µM -1.20693451238149 0.0976488186178319 no 3060 0.113728682584285 4347 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1511 0906-3109 28.5 µM -1.21219737341714 0.0966787307753643 no 3061 0.112718418346628 4302 2882180 SGTC_3074 9116018 49.47 µM -1.21232919589791 0.0966545235206132 no 3062 0.112693196097514 4350 17027303 SGTC_2846 9008642 19.48 µM -1.21483429578169 0.0961953447419321 no 3063 0.112214648752814 4329 2992898 SGTC_1880 MG-132 525 µM -1.21988990742063 0.095273550717422 no 3064 0.111253306144405 4250 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1273 0849-0096 14.1 µM -1.22057631694113 0.095148900231062 no 3065 0.111123238914405 4323 5286025 SGTC_750 4073-0104 132 µM -1.22604095383459 0.0941608156357233 no 3066 0.110091631942773 4024 22330957 SGTC_2601 securinine 100 µM -1.22710850028333 0.0939686749643947 no 3067 0.109890906711134 4289 442872 A GABA receptor antagonist. SGTC_1622 st003707 19.4 µM -1.22733932986169 0.0939271675361825 no 3068 0.109847539576781 4324 10140899 SGTC_2683 piperine 63.03 µM -1.23400480948491 0.0927344208617039 no 3069 0.108600556045041 4310 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2234 tolnaftate 200 µM -1.23521674977686 0.0925187604154546 no 3070 0.108374923558104 4390 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1278 0874-0585 172 µM -1.23733893744291 0.0921420187968517 no 3071 0.107980639004379 4370 766306 SGTC_2802 7925815 54.55 µM -1.23884842134934 0.091874739512688 no 3072 0.107700818980268 4282 1262923 SGTC_2942 9052777 62.25 µM -1.23918841396576 0.0918146174675606 no 3073 0.107637865121933 4362 6469503 SGTC_1856 st057054 55.7 µM -1.2399722025587 0.0916761285173519 no 3074 0.107492837946398 4322 1266018 SGTC_2189 6047310 154.431 µM -1.24114028204869 0.0914700258353842 no 3075 0.107276965475709 4294 711535 SGTC_2725 haloperidol 53.21 µM -1.2436932448779 0.0910207622476982 no 3076 0.106806241555807 4263 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_14 0354-0009 295 µM -1.24456529963746 0.0908676760210696 no 3077 0.106645791152572 4415 1713507 SGTC_1602 st001878 87.6 µM -1.24513871252155 0.0907671195083499 no 3078 0.106540383078356 4297 595405 YLR310C CDC25 SGTC_2799 7812892 81.82 µM -1.24675211879904 0.0904846277039928 no 3079 0.106244200980494 4344 20205235 SGTC_469 w7 172 µM -1.24820645839577 0.0902305467933714 no 3080 0.10597772971414 4416 45115570 A P450 inhibitor. SGTC_2240 6690706 185.951 µM -1.24857672045766 0.0901659447437216 no 3081 0.105909965670803 4219 805876 SGTC_1558 st069300 45.6 µM -1.24946861547744 0.0900104710484056 no 3082 0.105746862800542 4275 24208000 SGTC_2425 5628681 7.85 µM -1.24951388821279 0.090002584494219 no 3083 0.105738588517673 4397 5714958 SGTC_2343 7990716 14.84 µM -1.2527640859401 0.0894377376624383 no 3084 0.105145787704462 4333 6456862 SGTC_1131 3454-3128 32.3 µM -1.25507729408954 0.0890373377930201 no 3085 0.104725351104416 4344 710982 SGTC_2110 5483698 200 µM -1.25620254021221 0.0888430487389 no 3086 0.104521273004591 4308 2848765 YHR062C RPP1 SGTC_1887 st057648 70.8 µM -1.25918148552998 0.0883302175634003 no 3087 0.103982393668853 4333 688672 SGTC_3043 9092303 49.47 µM -1.25976511418391 0.0882300037239155 no 3088 0.103877054018735 4353 25236084 SGTC_585 0kpi-0023 191 µM -1.26660824483535 0.0870612971869603 no 3089 0.102647701455005 4278 64601 SGTC_1409 3909-8004 61.9 µM -1.26784607464906 0.0868511345719615 no 3090 0.102426462327082 4388 2119279 SGTC_1277 0873-0036 22 µM -1.26957310795248 0.0865585471306157 no 3091 0.102118366799012 4414 5965735 SGTC_1474 0330-0125 5.35 µM -1.28692472545088 0.083659682062257 no 3092 0.0990602631474086 4391 X1474 SGTC_1258 0671-0043 57.1 µM -1.29135160579114 0.0829319133706489 no 3093 0.0982908917572174 4366 4298767 SGTC_2259 7964009 200 µM -1.29212562118658 0.0828051576903635 no 3094 0.0981568221764242 4394 313134 SGTC_3346 9158254 43.5805 µM -1.29333465674244 0.082607453234493 no 3095 0.0979476695697323 4363 17639500 SGTC_2194 5927483 104.545 µM -1.29336466630361 0.0826025505202711 no 3096 0.0979424823345769 4396 760979 SGTC_590 k048-0076 22.4 µM -1.29480261585507 0.0823678867871177 no 3097 0.0976941646915925 4387 6832814 SGTC_1371 2421-0008 32.7 µM -1.29531693688178 0.0822840750372592 no 3098 0.0976054594307435 4347 2827552 SGTC_3161 9100388 49.47 µM -1.29597665850135 0.0821766634203401 no 3099 0.0974917633278947 4442 25236368 SGTC_3248 9135562 49.47 µM -1.29722065427 0.0819744114449837 no 3100 0.0972776380306694 4331 17650701 SGTC_1652 st011932 78 µM -1.29833925076606 0.0817928676751822 no 3101 0.0970853921560319 4290 1551076 SGTC_2850 9015429 58.44 µM -1.2994494364373 0.0816129887487365 no 3102 0.0968948676559075 4361 6457570 SGTC_3198 9112019 49.47 µM -1.30185356249599 0.0812244803937974 no 3103 0.0964832247652751 4407 45595555 SGTC_2945 9067681 61.76 µM -1.30325446908323 0.0809987373293874 no 3104 0.0962439499107557 4426 16456930 SGTC_1250 0485-0349 40.2 µM -1.3033033728347 0.0809908655074308 no 3105 0.0962356050355321 4381 6842794 YDL195W SEC31 SGTC_1319 1306-0155 43.7 µM -1.30865201239932 0.0801333992450797 no 3106 0.0953261268963375 4420 3122360 SGTC_448 monastrol 171 µM -1.30900869272802 0.0800764631036669 no 3107 0.0952657031023527 4295 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.32169508905179 0.0780711912727351 no 3108 0.0931348523196734 4377 688667 SGTC_394 menadione 8.33 µM -1.32622988278388 0.0773637185044699 no 3109 0.0923817819635981 4398 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_4 0960-0234 25.671 µM -1.3284438937253 0.0770200849030648 no 3110 0.0920157535108558 4387 6821112 SGTC_8 0354-0001 70 µM -1.3296399193349 0.0768349346557629 no 3111 0.0918184694418373 4386 4993152 SGTC_1005 4092-0690 4.4 µM -1.33521974008737 0.0759756221290346 no 3112 0.0909022189603054 4401 1529343 SGTC_1029 k015-0030 64.7 µM -1.33646076278247 0.0757854986954694 no 3113 0.0906993585717666 4417 2208316 SGTC_2224 6650123 117.647 µM -1.34027533284109 0.0752033789473837 no 3114 0.0900779239752242 4408 2908370 SGTC_1476 4112-3294 3.34 µM -1.34084110582818 0.0751173306607047 no 3115 0.0899860234979674 4398 704369 SGTC_1008 4106-0037 6 µM -1.34484603982168 0.0745103665007364 no 3116 0.0893374794324191 4404 2905394 SGTC_1767 st044992 70.3 µM -1.34658657322819 0.074247751555422 no 3117 0.0890567104285341 4449 9600693 SGTC_3052 9092717 49.47 µM -1.34745291863883 0.0741172995070734 no 3118 0.0889172035259552 4404 25237534 SGTC_7 0192-1582 4.227 µM -1.34843864374394 0.073969084588621 no 3119 0.0887586709493202 4451 252616 SGTC_1749 st037932 54.2 µM -1.35062873524494 0.0736405902243 no 3120 0.088407195576885 4420 594497 SGTC_2446 5162541 200 µM -1.35090029875029 0.0735999359415731 no 3121 0.0883636862599884 4377 1549321 SGTC_624 k048-0052 28 µM -1.35114568216576 0.0735632156966115 no 3122 0.0883243851855913 4386 6835531 SGTC_924 2046-0044 21.3 µM -1.35281493345083 0.0733137933130149 no 3123 0.0880573803793488 4393 3623589 SGTC_1241 0364-0022 50.8 µM -1.35361212166731 0.0731949045671058 no 3124 0.0879300788053063 4392 4563895 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.35515435063012 0.0729653228884527 no 3125 0.087684192660768 4463 279621 SGTC_1877 wortmannin 25 µM -1.35672784418147 0.0727316555168928 no 3126 0.087433850896415 4417 312145 A covalent inhibitor of PI 3-kinase. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.35895686124997 0.0724016227674746 no 3127 0.0870801294584791 4479 5357218 A potent inhibitor of glutathione S-transferases. SGTC_331 k048-0133 24.5 µM -1.35933722956253 0.0723454194551734 no 3128 0.0870198759288778 4371 6813582 SGTC_1172 0370-0043 85 µM -1.36473111379515 0.0715520118390866 no 3129 0.0861687883788832 4435 376585 SGTC_633 0437-0093 97.7 µM -1.36576782843377 0.0714002852485072 no 3130 0.0860059235742982 4340 2831118 SGTC_1234 0326-0494 15.5 µM -1.36632139393033 0.0713193703148626 no 3131 0.0859190544545912 4474 1547813 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.36684195967162 0.071243343208671 no 3132 0.0858374237950487 4416 140250 A respiratory chain inhibitor. SGTC_2979 9012552 45.46 µM -1.36755774046508 0.0711389071291503 no 3133 0.0857252759847481 4417 17100905 SGTC_932 2857-0803 154 µM -1.36770904223671 0.0711168464848257 no 3134 0.0857015842261021 4432 674898 SGTC_1022 4477-0945 21.3 µM -1.37105454003549 0.0706303953719005 no 3135 0.0851789774023801 4361 4648966 SGTC_899 1083-0020 478 µM -1.37137057566153 0.0705845748268215 no 3136 0.0851297325678779 4463 767123 SGTC_927 2425-1185 123 µM -1.37249299781664 0.0704220246762292 no 3137 0.0849550086061513 4360 730375 SGTC_1225 1216-0074 20.6 µM -1.37413208943327 0.0701851672196534 no 3138 0.0847003394260904 4424 4241466 SGTC_358 0075-0058 9.45 µM -1.38037219449231 0.0692890426151851 no 3139 0.083736038424505 4385 1069125 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.3806894129692 0.0692437242503645 no 3140 0.0836872389493097 4422 15053 SGTC_387 norethindrone acetate 66.7 µM -1.38235470624896 0.0690061921656621 no 3141 0.083431408094656 4431 541197 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.38250477871734 0.068984817196487 no 3142 0.0834083821002083 4463 65057 A dermal irritant. YDR527W RBA50 SGTC_1485 3909-9022 254 µM -1.38813654551966 0.0681863626581489 no 3143 0.0825477350381097 4490 714516 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.38924676933496 0.0680298035980132 no 3144 0.0823788621713457 4434 115019 SGTC_357 1325-0123 420 µM -1.39655244412699 0.0670065011325475 no 3145 0.08127409974252 4447 1098503 SGTC_3099 9120367 49.47 µM -1.39961364764421 0.0665812758026177 no 3146 0.0808145224389059 4470 24824940 SGTC_689 0833-0039 98 µM -1.39975426398811 0.0665617933748005 no 3147 0.0807934589934325 4401 5374726 SGTC_566 0958-0068 16.5 µM -1.40375059868236 0.0660099430428333 no 3148 0.0801965646831047 4350 6815365 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.40546961442427 0.0657736588574884 no 3149 0.0799408393441489 4430 1377 SGTC_1034 k072-0165 12.7 µM -1.40787140296852 0.0654446239371483 no 3150 0.0795845761712049 4451 5835461 SGTC_1835 st008666 49.2 µM -1.40849845571294 0.0653589308562673 no 3151 0.0794917619620217 4388 690455 SGTC_2251 lansoprazole 556 µM -1.40896125717383 0.0652957402148574 no 3152 0.0794233122240769 4402 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_982 1491-0518 27.5 µM -1.41026504247964 0.0651179769584936 no 3153 0.079230718289456 4393 3091256 SGTC_269 exalamide 29 µM -1.41448822612345 0.0645447491123053 no 3154 0.0786093009701023 4397 3316 A derivative of salicylamide. SGTC_703 3875-0075 71.8 µM -1.41833105804922 0.0640265610986617 no 3155 0.078047066593444 4488 2850814 SGTC_1033 k072-0102 21.3 µM -1.44312296010165 0.0607608705873607 no 3156 0.0744929182775239 4422 5965931 SGTC_1396 3511-0007 98.6 µM -1.44406708377946 0.0606391307027223 no 3157 0.0743600530369802 4486 X1396 SGTC_2337 9009472 200 µM -1.44613736221523 0.0603728469124274 no 3158 0.0740693390762473 4434 5742383 SGTC_2216 7189485 200 µM -1.44921111233003 0.0599791833715562 no 3159 0.0736393175878723 4475 731273 SGTC_2701 st077767 14.721 µM -1.45238765796683 0.0595744696567417 no 3160 0.0731969230467324 4443 5721188 SGTC_1016 4226-1401 38 µM -1.45254045547443 0.0595550562869954 no 3161 0.0731756944512793 4471 2901613 SGTC_1358 1509-0022 2.48 µM -1.45442556030206 0.0593159559197001 no 3162 0.0729141788573781 4499 3258434 SGTC_1018 4259-0013 28.1 µM -1.45527966342228 0.0592078724057518 no 3163 0.0727959271606663 4508 6801262 SGTC_2293 7624732 200 µM -1.45754320044246 0.058922177365235 no 3164 0.0724832477249659 4369 894453 SGTC_3156 9099931 49.47 µM -1.46115911473585 0.0584680357985133 no 3165 0.071985890166558 4518 18111053 SGTC_1055 3448-0672 86 µM -1.46131482480083 0.0584485412613569 no 3166 0.0719645316524546 4440 748378 SGTC_220 paclitaxel 373.376 µM -1.46762775489428 0.0576624671127006 no 3167 0.0711026822975845 4451 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2895 9054447 58.44 µM -1.47087761576375 0.0572610548002341 no 3168 0.0706621086091334 4544 2697450 SGTC_362 0310-0100 9.03 µM -1.47255402342979 0.0570548518425414 no 3169 0.0704356649053853 4503 790235 SGTC_2346 9031566 143.75 µM -1.47293824260848 0.0570076742235894 no 3170 0.0703838444970267 4449 4771086 SGTC_2138 5575593 77.673 µM -1.47531158058051 0.0567169365652145 no 3171 0.0700643972066523 4488 762213 SGTC_142 0335-0849 62.6745 µM -1.4762675378399 0.0566001607858441 no 3172 0.0699360425349992 4450 3889043 YPR107C YTH1 SGTC_420 mitomycin C 81.9 mM -1.4790580880898 0.0562603621280326 no 3173 0.0695623952613026 4463 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1209 2323-2347 50.3 µM -1.48516856854272 0.0555219207480286 no 3174 0.0687495879658846 4496 5412760 SGTC_1831 st055328 12 µM -1.48521351693146 0.0555165172972222 no 3175 0.0687436362464115 4472 1103068 SGTC_1300 1094-0077 113 µM -1.49222095522713 0.0546791863703211 no 3176 0.0678206152997686 4457 5532636 SGTC_2600 tangeritin 87.95 µM -1.49318166368793 0.0545651720747264 no 3177 0.0676948202609188 4403 68077 A bioactive flavone. SGTC_1028 k015-0029 4.8 µM -1.49741916471748 0.0540645186909095 no 3178 0.0671421123224616 4458 4588309 SGTC_1199 1638-0010 4.46 µM -1.4977407451609 0.0540266734450464 no 3179 0.0671003106505501 4499 3111136 SGTC_3325 9138760 55.175 µM -1.50258321097012 0.0534593188226516 no 3180 0.0664732777306574 4437 43844959 SGTC_2304 7443016 91.4 µM -1.50263144258468 0.0534536917316031 no 3181 0.0664670552926819 4443 939854 SGTC_108 0509-0257 621.132 µM -1.50412345151873 0.0532798535849516 no 3182 0.0662747914752056 4456 536624 SGTC_1857 st056007 79.3 µM -1.51094961499734 0.0524902262360903 no 3183 0.0654006442453139 4485 619834 SGTC_1364 1653-0028 37.6 µM -1.51176792616361 0.0523961935971544 no 3184 0.0652964557723502 4499 5718652 SGTC_354 2783-3500 4.88 µM -1.51676247159876 0.0518251632178375 no 3185 0.0646633326258697 4479 6740761 SGTC_2287 7945887 168.79 µM -1.52141243672165 0.0512979854132044 no 3186 0.0640781849245386 4519 1245853 SGTC_2598 perillyl alcohol 100 µM -1.52219953418523 0.051209173916552 no 3187 0.0639795459113393 4507 10819 An apoptosis inducer. SGTC_909 3448-9333 149 µM -1.52691176281764 0.0506800293445943 no 3188 0.0633914770954959 4438 3344074 SGTC_2885 9057732 51.95 µM -1.53240004519121 0.0500692396820696 no 3189 0.0627118731624798 4520 6471414 SGTC_1318 1280-3875 124 µM -1.53251591931518 0.0500564076256488 no 3190 0.0626975861315523 4531 373245 SGTC_318 1488-0629 67.2 µM -1.53295992610233 0.0500072619891754 no 3191 0.0626428645291407 4546 3662576 SGTC_159 3970-0959 50 µM -1.53303560857207 0.0499988887874293 no 3192 0.0626335407601235 4528 6615653 SGTC_606 k015-0008 38.6 µM -1.5338013074716 0.0499142378240548 no 3193 0.0625392706261077 4574 1970475 SGTC_2256 7954252 200 µM -1.53702092770241 0.0495595464763006 no 3194 0.0621440923108978 4512 2972920 SGTC_2528 xanthyletin 44.79 µM -1.53910521095361 0.0493310047724207 no 3195 0.0618893065542278 4541 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2824 7998404 51.95 µM -1.54300414871202 0.0489057459906907 no 3196 0.0614148846591152 4495 837851 SGTC_3256 9138902 49.47 µM -1.54487083660068 0.0487031850801147 no 3197 0.0611887544151512 4625 17228773 SGTC_705 1124-0212 310 µM -1.55861003819825 0.0472328531184581 no 3198 0.0595443528550683 4514 9554485 SGTC_3053 9095903 49.47 µM -1.55919687613026 0.0471708524225075 no 3199 0.0594748949991297 4626 17174018 SGTC_2007 4011539 71.82 µM -1.56408398122891 0.0466570496456835 no 3200 0.0588989236680062 4486 45595301 SGTC_1051 3253-3903 78 µM -1.56488762461972 0.0465729906382255 no 3201 0.0588046304545932 4504 5509239 SGTC_3154 9100113 49.47 µM -1.56535984176023 0.0465236546696827 no 3202 0.0587492794807431 4515 25237525 SGTC_2371 9071574 200 µM -1.56559742954658 0.0464988480068543 no 3203 0.0587214460742187 4536 45596039 SGTC_3344 9148862 3.898 µM -1.5748091259268 0.045545207744232 no 3204 0.0576502546560727 4553 4905352 SGTC_989 1501-0895 10.3 µM -1.57514128886173 0.0455111165673265 no 3205 0.0576119177269668 4516 2830112 SGTC_399 oxolinic acid 75 µM -1.57994166611318 0.0450207225016269 no 3206 0.0570601130556352 4512 4628 A DNA gyrase inhibitor. SGTC_781 4335-2806 94.4 µM -1.58188362643473 0.0448235490634775 no 3207 0.0568380697303651 4576 845254 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.58897586040246 0.044109351320532 no 3208 0.0560329213689267 4518 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1092 toremifene 6.32 µM -1.58991323439169 0.04401564674194 no 3209 0.055927182043063 4535 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.59148168537073 0.0438592156234996 no 3210 0.0557506069587185 4438 4330530 SGTC_1534 6-azauridine 81.6 µM -1.59646581217956 0.0433650931786538 no 3211 0.0551924163989722 4581 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1430 4049-0248 69.1 µM -1.60958520731808 0.0420859087923575 no 3212 0.0537442198665003 4575 22774488 SGTC_809 3998-0021 90 µM -1.61873749612034 0.0412117465776612 no 3213 0.0527518777682662 4511 715485 SGTC_2855 9016525 58.44 µM -1.62026425966192 0.0410673637260438 no 3214 0.0525877614360279 4495 43811474 SGTC_2317 5986382 200 µM -1.62902067394505 0.0402471921821434 no 3215 0.0516543212334104 4575 877883 SGTC_2904 7225135 42.03 µM -1.63205644681705 0.0399659708658782 no 3216 0.0513337977870071 4621 4446116 SGTC_2015 5119600 184 µM -1.63647850440008 0.0395591892683249 no 3217 0.0508697404477843 4544 2828786 SGTC_648 0375-0473 33.3 µM -1.6368709812508 0.039523248920345 no 3218 0.0508287152307566 4556 1713139 SGTC_949 1165-0505 146 µM -1.64075273212228 0.0391692131709852 no 3219 0.0504243769077492 4534 6244267 SGTC_2414 st077232 92.9 µM -1.64163973996819 0.0390886768525733 no 3220 0.0503323433924513 4510 729801 SGTC_1609 st001574 46.4 µM -1.64261737484816 0.0390000682289199 no 3221 0.0502310617979477 4550 3960012 SGTC_2734 clemastine 41.6 µM -1.64342762571874 0.038926754575218 no 3222 0.0501472441181328 4633 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1957 st077035 62.4 µM -1.649402377415 0.0383896017440034 no 3223 0.0495326140009515 4583 705593 SGTC_550 4123-0385 25.7 µM -1.65500715214451 0.0378912189027772 no 3224 0.0489615235630549 4587 5731123 SGTC_2924 9010168 62.78 µM -1.66333681525142 0.0371603014911982 no 3225 0.0481225166135944 4565 2993929 SGTC_67 0335-0847 266 µM -1.66499309746234 0.037016346972284 no 3226 0.0479570664694304 4573 4552207 YOR254C SEC63 SGTC_2301 7769476 200 µM -1.66690281803045 0.0368509311882794 no 3227 0.0477668652334256 4569 977820 SGTC_2781 5567276 71.43 µM -1.67198513189101 0.0364136553420927 no 3228 0.0472636269821436 4564 2853274 SGTC_3092 9117248 49.47 µM -1.67432695302886 0.0362136019666923 no 3229 0.0470331800799933 4685 17141857 SGTC_1715 st032160 10.2275 µM -1.67468439847904 0.0361831459886236 no 3230 0.0469980850469777 4485 5289825 SGTC_549 1661-1316 519 µM -1.67796326392569 0.0359047491400708 no 3231 0.0466771354072542 4598 2857282 SGTC_92 0063-0024 660.874 µM -1.68829715011341 0.035038795809656 no 3232 0.0456771010147025 4669 3594437 SGTC_609 0986-0026 86.3 µM -1.68865360963012 0.0350092339244941 no 3233 0.0456429153088844 4578 2848610 SGTC_574 1315-0397 40 µM -1.69336969284156 0.0346200433158906 no 3234 0.045192559978727 4576 6794277 SGTC_2394 5221648 200 µM -1.69427827635739 0.0345454730423241 no 3235 0.0451062082783172 4599 788586 SGTC_2365 9042475 200 µM -1.69684518705451 0.0343355113993065 no 3236 0.0448629665829932 4603 6464479 SGTC_453 enantio-paf c16 10 µM -1.71291260105629 0.0330449768118919 no 3237 0.0433643098440183 4195 13871343 A lipid and platelet activating factor SGTC_105 0111-0055 734.78 µM -1.71307067658913 0.033032481529478 no 3238 0.043349768960045 4597 5179370 SGTC_1098 clofazimine 15.1 µM -1.72660428991332 0.0319770470461903 no 3239 0.0421193774859492 4634 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2472 5377652 49.4 µM -1.73354805427018 0.0314464335920115 no 3240 0.0414991520542958 4630 1610903 SGTC_1245 0418-0076 17.2 µM -1.73974917570103 0.0309787427593704 no 3241 0.0409515351725832 4603 6790114 SGTC_741 4582-0002 126 µM -1.74796468190501 0.030368005272419 no 3242 0.0402350716318841 4623 2912688 SGTC_962 1254-0300 21.5 µM -1.75773900935078 0.0296544159749577 no 3243 0.0393959635676756 4597 7340576 SGTC_971 1315-0384 26.7 µM -1.75883332440032 0.0295753971838749 no 3244 0.039302911391513 4638 6769120 SGTC_2370 9071495 200 µM -1.76156924027518 0.029378605332116 no 3245 0.039071052403907 4639 21791103 SGTC_1945 st075991 56.6 µM -1.76192682494871 0.0293529651284012 no 3246 0.0390408308433339 4592 1084980 SGTC_2135 5326629 150.42 µM -1.76525231028749 0.0291154037834219 no 3247 0.0387606852997463 4575 5020077 SGTC_1766 st045414 44.774 µM -1.76715885775111 0.0289799284303122 no 3248 0.0386008138617114 4612 253960 SGTC_759 3486-0358 89.3 µM -1.77083809810444 0.0287199700071491 no 3249 0.0382938142617595 4594 875103 SGTC_2572 astragaloside iv 100 µM -1.77609424959862 0.0283519604092963 no 3250 0.0378586919429974 4579 45006101 An anti-inflammatory agent. SGTC_3274 9138298 49.47 µM -1.77722330940032 0.0282734234170004 no 3251 0.0377657528928603 4582 17015756 SGTC_2591 skatole 100 µM -1.77829811186675 0.0281988288597954 no 3252 0.0376774531522357 4597 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_131 0141-0277 33.849 µM -1.78644543402804 0.0276386915895028 no 3253 0.0370135823855558 4574 1547771 SGTC_1570 verbenone 133 µM -1.79405927097602 0.0271236447913256 no 3254 0.0364018544879134 4630 29025 A natural terpanoid with antifungal properties. SGTC_2028 5153890 36.43 µM -1.79595379428033 0.02699673932352 no 3255 0.036250932947112 4612 2830968 YPR165W RHO1 SGTC_454 lyso-paf C-16 6.67 µM -1.79826491868223 0.0268425990605793 no 3256 0.0360675181236187 4625 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2689 tacrolimus 100 µM -1.79849771254911 0.0268271137081308 no 3257 0.0360490854069748 4603 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_86 0417-1630 471.922 µM -1.79889702438112 0.0268005690197269 no 3258 0.0360174856946948 4640 3634867 SGTC_1725 st036284 20.55 µM -1.80344744239336 0.0264996210416278 no 3259 0.0356589862631437 4612 707914 SGTC_1310 1188-0297 994 nM -1.8075882936956 0.0262282192786377 no 3260 0.0353353007617449 4527 1588352 SGTC_1308 1187-1617 41.4 µM -1.80777473101123 0.0262160545847865 no 3261 0.0353207840529251 4655 2882570 SGTC_614 0462-0418 107 µM -1.82123743626093 0.0253500234692489 no 3262 0.0342853860431807 4422 5188303 SGTC_878 0828-0289 13.7 µM -1.82242958573662 0.025274503359448 no 3263 0.0341949144266463 4612 745350 YLR208W SEC13 SGTC_419 nsc-638432 893 µM -1.82259651822714 0.0252639436055208 no 3264 0.0341822616835221 4619 368090 SGTC_2676 harmalol 100 µM -1.837145743685 0.0243576911148608 no 3265 0.0330941913831177 4626 5459187 A monoamine oxidase inhibitor SGTC_215 1287-0124 461.5 µM -1.85045981778631 0.023552445973973 no 3266 0.0321236521758826 4693 5560863 SGTC_2185 6113692 200 µM -1.85299665617475 0.0234015838901112 no 3267 0.0319414189655958 4633 874150 SGTC_171 k064-0041 9.68 µM -1.85637659239717 0.0232018481059918 no 3268 0.0316999493837171 4623 53325 SGTC_2017 5132927 60.65 µM -1.8833666894273 0.0216577927241553 no 3269 0.0298253456767563 4615 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1057 3448-5381 134 µM -1.89040727677929 0.0212695976907884 no 3270 0.0293517554781792 4640 5497911 SGTC_1093 fluphenazine 7.97 µM -1.90003932880967 0.0207480626482075 no 3271 0.0287139793205262 4678 6602611 An atypical antipsychotic. SGTC_2808 7946468 45.46 µM -1.90534433351494 0.0204654720536026 no 3272 0.0283676630704493 4636 2970879 SGTC_345 1362-0200 395 µM -1.90597723759338 0.020431976870844 no 3273 0.0283265794763394 4658 1419823 SGTC_3163 9099914 49.47 µM -1.90982172241251 0.0202295118430419 no 3274 0.0280780857086523 4727 16268368 SGTC_1819 st053448 58.6 µM -1.9130114970245 0.0200628199151857 no 3275 0.0278732903146852 4622 2857616 SGTC_1203 3992-3522 103 µM -1.92379574522623 0.0195078564674548 no 3276 0.027190095483617 4659 5322312 SGTC_816 0325-0417 81.3 µM -1.93975371793656 0.0187106029566363 no 3277 0.0262048138871977 4676 68101 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.94078221938847 0.0186601847019317 no 3278 0.0261423492985642 4685 1273210 SGTC_2682 pyrogallin 40.03 µM -1.94558632601213 0.0184262111243214 no 3279 0.0258522254327853 4697 822798 An ATP competetive kinase inhibitor. SGTC_3035 9091303 49.47 µM -1.96076254892727 0.0177034331337795 no 3280 0.0249533643591841 4702 25237002 SGTC_213 1246-0773 967 nM -1.96354369020973 0.0175736365387626 no 3281 0.0247915165233764 4696 6251622 SGTC_551 k048-0028 34.9 µM -1.97916215209309 0.0168597121926312 no 3282 0.0238988763309969 4640 6836383 SGTC_2996 9066192 71.4286 µM -1.98005958578733 0.0168194548470585 no 3283 0.0238484168222391 4648 6472854 SGTC_1837 st055472 66.5 µM -1.98149658144764 0.0167551648950907 no 3284 0.0237678061801879 4696 676091 SGTC_1821 st053465 65.6 µM -1.98822102698588 0.0164571052409158 no 3285 0.0233936252233346 4701 675086 SGTC_3275 9138069 49.47 µM -1.99437891855015 0.0161881512932629 no 3286 0.0230553302961999 4695 17617007 SGTC_1552 6-methylflavone 10.6 µM -1.99517252422127 0.0161537649838099 no 3287 0.0230120333044641 4658 689013 SGTC_2222 6885208 172.143 µM -1.99540357401524 0.0161437655481761 no 3288 0.022999440727386 4714 609514 SGTC_98 0074-0023 107.663 µM -1.99555981491257 0.0161370067185043 no 3289 0.0229909286425158 4685 3563821 SGTC_1908 st060353 56.5 µM -1.99879166665974 0.0159977427705634 no 3290 0.0228154499112875 4669 4227716 SGTC_1958 st076513 41.9 µM -1.99915258566408 0.0159822545227496 no 3291 0.0227959234551526 4627 732122 YGL099W LSG1 SGTC_589 1227-0070 34.1 µM -2.00363214722672 0.0157910888012715 no 3292 0.0225547397916039 4714 2841384 SGTC_1888 azatryptophan 97.5 µM -2.00440111277012 0.0157584711166096 no 3293 0.0225135551102286 4697 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_96 0929-0093 37.281 µM -2.02786918219958 0.0147904364758712 no 3294 0.0212868005939782 4708 6991579 SGTC_1224 0823-0416 294 µM -2.04087566561168 0.0142762932504181 no 3295 0.0206315935741119 4709 3598164 SGTC_2289 7946404 165.07 µM -2.04196042131512 0.0142341171244939 no 3296 0.0205777287370987 4669 1246120 YPR165W RHO1 SGTC_1649 st011737 51.3 µM -2.04895291576252 0.0139648111819426 no 3297 0.0202333596214051 4698 1761035 SGTC_995 3931-2021 34.6 µM -2.0554929204919 0.0137169191091364 no 3298 0.0199157093808133 4679 730143 SGTC_2119 5528445 120.635 µM -2.06127634636383 0.0135008765050817 no 3299 0.0196383417464972 4711 791935 SGTC_1572 epiandrosterone 68.9 µM -2.07106801695581 0.0131417981395503 no 3300 0.0191762201059251 4673 441302 A steroid. SGTC_3172 9105863 49.47 µM -2.0748075961389 0.0130068551437791 no 3301 0.0190021851492916 4774 2348785 SGTC_701 4424-0219 185 µM -2.07496775159345 0.0130011027703858 no 3302 0.018994761824995 4709 2911779 SGTC_237 nikkomycin 200 µM -2.08212162326715 0.0127463875390317 no 3303 0.0186656809568974 4705 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1644 st010134 20.9 µM -2.08415152066775 0.0126749036194026 no 3304 0.0185731934494679 4689 3818134 SGTC_140 0062-0056 502.533 µM -2.08688058463751 0.0125793450950039 no 3305 0.0184494651702688 4629 3758964 SGTC_1729 st035615 45.989 µM -2.08706853089676 0.0125727871467261 no 3306 0.0184409700990707 4680 17385451 SGTC_433 pimozide 108 µM -2.10217664142966 0.0120552141479536 no 3307 0.0177689025911923 4650 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_230 MPP+ 141.667 µM -2.10469702507638 0.0119706935854631 no 3308 0.017658844808275 4699 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1632 st005650 90 µM -2.1157098973242 0.0116073805395041 no 3309 0.0171847441472461 4708 2759605 SGTC_974 1326-0144 138 µM -2.13126258933869 0.011110624180501 no 3310 0.0165337576219596 4714 5411856 SGTC_2830 7992007 71.43 µM -2.13524787191203 0.0109863487129292 no 3311 0.0163703842225193 4649 1952075 SGTC_723 4182-0001 115 µM -2.15141811131402 0.010494428842398 no 3312 0.0157216064635245 4707 744821 YLR208W SEC13 SGTC_1205 4161-2785 76 µM -2.16071130496879 0.010220493430941 no 3313 0.0153588235469443 4702 3498106 SGTC_3243 9134147 49.47 µM -2.16612491478275 0.0100638084198461 no 3314 0.0151508214003748 4772 24282180 SGTC_3028 9087778 49.47 µM -2.18183440700666 0.00962093973570939 no 3315 0.0145608781139059 4697 17217395 SGTC_2326 6164455 177.58 µM -2.19021793865697 0.00939164284166618 no 3316 0.0142542174333848 4660 2888790 SGTC_1883 5-benzylidenerhodanine 20 µM -2.19159772544858 0.00935436616227332 no 3317 0.0142042831668419 4720 1273210 SGTC_1656 st012921 11 µM -2.19525178275717 0.00925627180438935 no 3318 0.0140727707947268 4649 6732821 SGTC_2058 5236698 133 µM -2.20250408489851 0.0090642446196967 no 3319 0.0138148604505017 4709 766665 SGTC_2589 lobaric acid 100 µM -2.2033647616873 0.00904168873763271 no 3320 0.0137845248913886 4664 73157 A novel microtubule depolymerizer. SGTC_1902 st060212 70.5 µM -2.20661166078074 0.00895703870401342 no 3321 0.013670600801077 4720 688944 SGTC_2951 9072950 58.06 µM -2.21114420305009 0.00884003200386979 no 3322 0.0135129263932803 4673 16488155 SGTC_2377 9073351 62.6 µM -2.2358073274807 0.00822654515818108 no 3323 0.0126821973787035 4710 7337946 YHR072W ERG7 SGTC_113 0099-0221 2.5 µM -2.24102779954127 0.00810159125154485 no 3324 0.0125121371711422 4698 89219 SGTC_248 streptozotocin 5.23457 mM -2.26132438993708 0.00763149414274276 no 3325 0.011869588496677 4747 5300 DNA alkylating agent. SGTC_1925 st057770 10.1 µM -2.26859226320557 0.00746909582177275 no 3326 0.0116465662698175 4714 5989122 SGTC_1944 st076371 56.9 µM -2.30666103247964 0.00666723332016719 no 3327 0.0105368621097446 4728 24208455 SGTC_2170 morpholine 200 µM -2.31406174488199 0.0065204974996834 no 3328 0.0103321677296403 4755 121171 Reacts with secondary amines. SGTC_3210 9128157 49.47 µM -2.32328797796885 0.00634157148068143 no 3329 0.0100818436092228 4674 17590849 SGTC_555 4296-0685 37 µM -2.36469582882339 0.00559096278655213 no 3330 0.00902244227127056 4750 2908540 YHR072W ERG7 SGTC_864 0469-0573 172 µM -2.40440913042522 0.0049463027406895 no 3331 0.0080993164303903 4740 689425 SGTC_2197 6588183 93.1375 µM -2.40455433456809 0.00494407255386695 no 3332 0.00809609947331797 4777 884136 SGTC_2582 agaric acid 100 µM -2.45163178431404 0.00426654308065264 no 3333 0.00711050508584095 4494 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1207 2099-0101 141 µM -2.46265882095348 0.00412037403757233 no 3334 0.00689555391659672 4770 5837381 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.47045942797463 0.00401969600682756 no 3335 0.00674698124165404 4754 91467 include heat shock SGTC_257 daunorubicin 18.5 µM -2.47248266450926 0.0039939455674315 no 3336 0.00670891105303609 4776 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1391 3442-0225 151 µM -2.47271876089637 0.00399095033090438 no 3337 0.00670448094275426 4771 5227075 SGTC_2001 4023502 57.655 µM -2.49511788438677 0.0037157692997014 no 3338 0.00629576453835125 4746 108941 YCR052W RSC6 SGTC_1966 st070145 16.1 µM -2.51478187417326 0.00348835084524671 no 3339 0.00595530243890954 4757 3748532 SGTC_2091 4-phenylthiadiazole 200 µM -2.51769825580511 0.00345570838097383 no 3340 0.00590622348608361 4769 270010 SGTC_1907 st060210 83.7 µM -2.53322325735266 0.00328651478899261 no 3341 0.00565094719199276 4761 688793 SGTC_2108 5365811 200 µM -2.55927447113243 0.0030192798914051 no 3342 0.00524454450215848 4779 780283 SGTC_2188 6126565 140.678 µM -2.59425831603659 0.00269122840630545 no 3343 0.00473976174010017 4740 874518 SGTC_552 k242-0005 476 µM -2.61424580976747 0.00251859112339169 no 3344 0.0044712336972583 4786 4088318 SGTC_2930 9013230 14.89 µM -2.63282543831599 0.00236716014623559 no 3345 0.00423389279457966 4745 2995857 SGTC_613 3914-0030 117 µM -2.73097286921725 0.00169559597071852 no 3346 0.0031573834939622 4666 1145395 SGTC_1659 st012954 42.1 µM -2.81589214618518 0.00125993022873687 no 3347 0.00243209966284418 4789 24207262 SGTC_2031 5180455 200 µM -2.8415168957643 0.00115019023535447 no 3348 0.00224497363744644 4781 29949 SGTC_1292 0kpi-0043 232 µM -2.97198156534741 0.000715364973050143 yes 3349 0.00147942224675017 4796 3333905 SGTC_543 3844-1095 191 µM -3.0063881925912 0.000629235019592886 yes 3350 0.00132185628446102 4782 4230703 SGTC_1904 st060225 78 µM -3.01716240805061 0.000604299636283562 yes 3351 0.00127576534569913 4787 66595 SGTC_950 1165-0508 94.1 µM -3.05549032389517 0.000522808260559978 yes 3352 0.00112346426468334 4770 6148369 SGTC_819 1013-0258 27.7 µM -3.33290906821973 0.000174756263357379 yes 3353 0.000429715131254917 4800 5753198 SGTC_929 2805-0021 398 µM -3.33914842392308 0.000170338334367962 yes 3354 0.000420178253020599 4798 3098024 SGTC_2051 5263410 176 µM -3.51474384679282 8.14330992205153e-05 yes 3355 0.000220089173120225 4795 227584 SGTC_1962 st076595 64.5 µM -4.37798629287544 1.32291037419855e-06 yes 3356 5.98904408502739e-06 4807 279619