SGTCid condition conc unit RPA34|YJL148W.score RPA34|YJL148W.strain.pval RPA34|YJL148W.strain.significant RPA34|YJL148W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_538 2922-0838 53.3 µM 8.50934532570592 2.36718600127394e-22 yes 1 8.74590803574476e-18 1 777039
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 7.96468549542289 7.52155336314339e-20 yes 2 8.28222638112763e-16 17 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2651 TUB2.036 5 µM 7.42597223638004 1.56394680470616e-17 yes 3 5.59772407475094e-14 42 15992207 YFL037W TUB2
SGTC_1930 st074634 34.3 µM 6.45588424114233 9.45559399620566e-14 yes 4 5.37944137947255e-11 8 684253 YOR116C RPO31
SGTC_202 3594-0513 34.79 µM 6.23380043506673 5.89574716095023e-13 yes 5 2.27626490647212e-10 3 708429
SGTC_534 k292-0788 63.4 µM 4.78439167612841 2.05478152684845e-08 yes 6 8.57529798335503e-07 12 4146317
SGTC_2544 sphondin 68.51 µM 4.75043180920767 2.54581339520692e-08 yes 7 1.01491368082679e-06 12 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2688 kanamycin b 96.69 µM 4.55194289401936 8.66102671368596e-08 yes 8 2.65763822836311e-06 291 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_65 0798-0905 34.986 µM 4.25357104896511 4.98693076810968e-07 yes 9 1.05194071474849e-05 77 3602145
SGTC_535 2293-4129 48.2 µM 4.09987832222514 1.17812290915317e-06 yes 10 2.06683707819975e-05 55 396118 YIL048W NEO1
SGTC_422 cantharidin 155 µM 3.94459849344552 2.7279095309465e-06 yes 11 3.99668974125996e-05 58 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3193 9111931 49.47 µM 3.88902850290513 3.65812314716076e-06 yes 12 5.03231492130662e-05 27 17087244
SGTC_2671 danthron 100 µM 3.75690877976427 7.24017027009831e-06 yes 13 8.60125834595906e-05 51 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3194 9111903 49.47 µM 3.71452245774769 8.97303075049486e-06 yes 14 0.000101793894968565 28 17087251
SGTC_71 0417-1750 47.813 µM 3.65585280981627 1.20333319386345e-05 yes 15 0.000128164203023622 58 6811472
SGTC_2000 st075254 36.4 µM 3.64654429923271 1.26020697009255e-05 yes 16 0.000132895337029075 12 17234175
SGTC_1207 2099-0101 141 µM 3.63506371767613 1.3338766937557e-05 yes 17 0.000138955969622894 29 5837381
SGTC_1128 3448-9350 235 µM 3.50317837529061 2.53306852879791e-05 yes 18 0.000229870741330187 37 619386
SGTC_523 1934-0222 13.7 µM 3.4581526676244 3.13812398810663e-05 yes 19 0.000271946540962872 44 1361595
SGTC_623 k072-0108 16.9 µM 3.34510900858676 5.31605747401757e-05 yes 20 0.000411251183348043 43 5382803
SGTC_1712 st032288 53.4 µM 3.32321839207714 5.87699327523743e-05 yes 21 0.000444926092102613 232 2883011
SGTC_744 1594-0068 283 µM 3.30737939817203 6.31717163833657e-05 yes 22 0.000470866260412418 54 668392
SGTC_1525 8-methoxypsoralen 92.5 µM 3.24598600468354 8.33453841997179e-05 yes 23 0.000585222966531376 62 4114 Related to psoralen; DNA damaging agent.
SGTC_2781 5567276 71.43 µM 3.17407981094968 0.000114651075588775 yes 24 0.000751561765386737 100 2853274
SGTC_1915 st067105 30.6 µM 3.09940049279166 0.000158634396307754 yes 25 0.000969563515693274 92 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2126 5251174 33.877 µM 3.00708640574454 0.00023483116703831 yes 26 0.00131882389329973 95 790722
SGTC_829 1635-0120 117 µM 2.98925308755066 0.00025302406387173 yes 27 0.00139830188956313 87 285054
SGTC_2406 ethylparaben 405.7 µM 2.97207049614795 0.000271788625687813 yes 28 0.00147899378308889 87 8434 A possible steroid mimic.
SGTC_608 k048-0125 159 µM 2.95330827185628 0.000293754345184943 yes 29 0.00157193917411722 65 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2650 prasterone 100 µM 2.93699240687438 0.000314188187258851 yes 30 0.00165706109119958 30 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_66 0109-0187 42.4 µM 2.88268980126469 0.000392113069500923 yes 31 0.00197147757153389 78 759417
SGTC_1885 st057546 99.9 µM 2.80272749377069 0.000539956699225887 yes 32 0.00253362324142244 71 702008
SGTC_2751 anetholtrithion 17.25 µM 2.77687588410282 0.000597837263861916 yes 33 0.00274420663598467 92 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2298 7976326 193.81 µM 2.67442985471048 0.000888163679195881 yes 34 0.00374282171070288 56 2235818
SGTC_1923 st058458 19.1 µM 2.66961335097618 0.000904574105055455 yes 35 0.00379693183214314 126 3534982
SGTC_1568 digitonin 820 nM 2.60751438748263 0.00114262718763213 no 36 0.00456011188359153 116 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_550 4123-0385 25.7 µM 2.59527046138131 0.00119585571094769 no 37 0.00472582556400744 119 5731123
SGTC_861 0443-0273 110 µM 2.53776800810249 0.00147751736202879 no 38 0.00557809553689525 99 6149169
SGTC_2714 st079313 56.9 µM 2.52878434344764 0.00152662419105469 no 39 0.00572291657523137 88 2939799
SGTC_882 0843-0131 351 µM 2.50207595812514 0.00168153852935828 no 40 0.00617337159584273 113 5425421
SGTC_2027 5150920 200 µM 2.48495306112556 0.00178824829649689 no 41 0.00647842588353911 81 786715
SGTC_2489 cantharidin 73.42 µM 2.48316658828617 0.00179972924710122 no 42 0.00651100866660675 167 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2515 chrysin 20.77 µM 2.47286009795859 0.00186728406282841 no 43 0.00670183013279121 92 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2958 9077254 16.72 µM 2.46443494697367 0.00192421083198665 no 44 0.00686147358653948 133 16457351
SGTC_3327 9140648 26.9345 µM 2.46115849220327 0.00194677162420574 no 45 0.00692445862073102 80 8029710
SGTC_408 cantharidin 100 µM 2.41869518368737 0.0022617014095747 no 46 0.00778814326545264 139 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_739 1486-1183 203 µM 2.37726099134682 0.00261278704010033 no 47 0.00872087113094867 117 4346692
SGTC_1562 morin hydrate 59.1 µM 2.35262536442231 0.00284417845583477 no 48 0.00932070240943172 135 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1618 st003135 44.5 µM 2.33328587590021 0.00303860349888655 no 49 0.00981657312109545 112 1270615
SGTC_612 0302-0167 22.4 µM 2.33195961551647 0.00305236548983676 no 50 0.00985140788582765 180 235821
SGTC_2099 5377090 177.372 µM 2.32878043918177 0.00308558317673703 no 51 0.00993535009100753 153 2243829
SGTC_2749 bexarotene 57.39 µM 2.32673599573191 0.00310711619920648 no 52 0.00998966039430573 170 82146 An retinoic acid receptor inhibitor.
SGTC_656 4090-1979 187 µM 2.32304970075166 0.00314628412209941 no 53 0.0100882413154433 160 22330961
SGTC_2750 bromebric acid 70.15 µM 2.3196238945775 0.00318308211476831 no 54 0.0101806160449509 169 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2479 5617353 43.85 µM 2.31761381568954 0.00320485305248327 no 55 0.0102351593379799 169 2731746
SGTC_825 1988-2224 89.6 µM 2.30752757631541 0.00331613187648054 no 56 0.0105127133690234 169 1180859
SGTC_1271 0832-2808 169 µM 2.30488147260718 0.00334589516127253 no 57 0.0105866062589062 143 3663794
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.3016357914195 0.00338273027445941 no 58 0.0106778599753431 156 5393153
SGTC_84 0443-0269 128.823 µM 2.29325346765926 0.0034795527245972 no 59 0.0109167082538504 151 6150058
SGTC_873 0591-4978 488 µM 2.27462991232433 0.00370363224451275 no 60 0.0114640700763583 150 3305145
SGTC_2278 7948257 134.34 µM 2.24957410692533 0.00402550645587262 no 61 0.0122379968313448 140 1247028
SGTC_2699 st077704 54.6 µM 2.17411183043842 0.00515151284501427 no 62 0.0148483688553333 212 645852
SGTC_1489 4065-0444 182 µM 2.16150053140799 0.00536487474946605 no 63 0.0153283479750227 160 2877968
SGTC_1275 0867-0008 21.1 µM 2.15823410239559 0.00542140281331409 no 64 0.015454817618248 176 3422836
SGTC_593 1203-0218 61.7 µM 2.14307129823793 0.00569079824915695 no 65 0.0160536868655696 174 3666956
SGTC_604 1000-0114 314 µM 2.11103920971677 0.00629929190620326 no 66 0.0173844708997622 196 1572745
SGTC_537 1334-0398 209 µM 2.10451514001614 0.00643006226118399 no 67 0.017666767674525 202 5846986
SGTC_3076 9116187 49.47 µM 2.10065332428799 0.0065085963215041 no 68 0.0178357047166352 176 27241210
SGTC_1176 0848-0131 83.3 µM 2.08743855609698 0.00678378897372569 no 69 0.0184242548917923 223 6769040
SGTC_211 3455-0679 143.504 µM 2.08514112645568 0.00683266713110756 no 70 0.0185282460400841 216 748649
SGTC_2483 5729050 27.16 µM 2.07236781098216 0.00711013511426902 no 71 0.0191155764377433 246 2865180
SGTC_1388 3346-4487 254 µM 2.06535094446356 0.00726675080503284 no 72 0.0194449032691564 215 3345614
SGTC_517 1365-0151 113 µM 2.05396440880904 0.00752737465271514 no 73 0.0199895682886537 206 768657
SGTC_3011 9081274 71.4286 µM 2.05320239559012 0.00754510653988001 no 74 0.0200264760938989 233 6625322
SGTC_895 0964-0006 13.7 µM 2.02863533177129 0.00813684023077728 no 75 0.021247723543594 198 6738897
SGTC_2262 9014885 67.46 µM 2.01377048754998 0.00851435681650395 no 76 0.022016817795704 117 6457424
SGTC_790 1575-0012 79.1 µM 2.00861776306717 0.00864876003353243 no 77 0.0222888430231631 236 378741 YLR208W SEC13
SGTC_2237 6667747 47.222 µM 1.99571388761952 0.0089935389197172 no 78 0.0229825372803541 184 729940 YDL015C TSC13
SGTC_843 0310-0051 143 µM 1.98960678914416 0.00916087071481377 no 79 0.0233171338476364 210 2065037
SGTC_1212 0520-0165 585 µM 1.98360030868596 0.00932809777235675 no 80 0.0236502073880426 237 5403258
SGTC_464 bw-b 70c 158 µM 1.98201677510787 0.00937262754380315 no 81 0.0237386815882929 258 5353454
SGTC_152 4469-0003 551.229 µM 1.98148459484984 0.00938763441469501 no 82 0.0237684776395167 202 697280
SGTC_2015 5119600 184 µM 1.97241662463206 0.00964659010895882 no 83 0.0242810327827601 235 2828786
SGTC_1173 0443-0020 122 µM 1.96360771356003 0.00990410367659002 no 84 0.0247878010928354 252 5331295
SGTC_2899 9053889 58.44 µM 1.95533023771606 0.0101515311343008 no 85 0.02527205220118 177 6470052
SGTC_580 1123-0028 41 µM 1.94756683835337 0.0103884753316936 no 86 0.0257334074725532 316 1677248 YPR107C YTH1
SGTC_933 2914-0560 114 µM 1.94128353247277 0.0105837617933602 no 87 0.026111947918394 267 463887
SGTC_3315 9136395 68.55 µM 1.939334894904 0.0106449720218376 no 88 0.0262302862461791 225 16876844
SGTC_746 1095-0025 46.6 µM 1.93250707251461 0.0108618856072786 no 89 0.026648474980508 241 6749286
SGTC_1226 3909-7979 35.4 µM 1.92799182108953 0.0110074352049915 no 90 0.0269280717537955 274 6615510
SGTC_1058 3448-5425 97.3 µM 1.91732809864116 0.0113579337151231 no 91 0.0275981311888693 236 7279705
SGTC_2708 st078559 56 µM 1.89602551757715 0.0120872430635244 no 92 0.0289783351871421 148 17250902
SGTC_2103 5378138 10 µM 1.89408285994109 0.0121557281644847 no 93 0.0291070062072381 266 244142
SGTC_519 k048-0011 62.8 µM 1.88250720196679 0.0125708214338158 no 94 0.0298835914780961 260 6836379
SGTC_562 3772-2733 112 µM 1.86348046658687 0.0132797754982313 no 95 0.0311973491222381 336 2876874 YIL048W NEO1
SGTC_1314 1222-0010 41.1 µM 1.86270186607192 0.0133095081148392 no 96 0.0312521116017356 234 3526027
SGTC_2453 5731132 22.18 µM 1.85108748381027 0.0137599023915898 no 97 0.0320784842075961 263 1362040
SGTC_949 1165-0505 146 µM 1.8441324751154 0.0140358563319408 no 98 0.032581918080125 300 6244267
SGTC_2743 auranofin 4.32 µM 1.83978740899621 0.0142106656571946 no 99 0.0328997273396226 248 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3133 9127736 49.47 µM 1.83827196209334 0.0142720742215524 no 100 0.0330111702296276 259 27243420
SGTC_876 0720-0963 56.8 µM 1.83523205868079 0.0143959457970472 no 101 0.0332356564730137 267 765861
SGTC_773 4358-1457 44.6 µM 1.83456263023057 0.0144233480489941 no 102 0.0332852599864983 328 1186886
SGTC_766 1391-0721 126 µM 1.83366757364172 0.0144600562708534 no 103 0.0333516774074746 266 1020919 YIL115C NUP159
SGTC_2747 doxorubicin 7.63 µM 1.82604475406961 0.0147759568945801 no 104 0.0339217604079729 135 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2932 9016711 44.54 µM 1.81968350488961 0.0150441022186728 no 105 0.034403608361393 319 7117328
SGTC_246 cycloheximide 667 µM 1.81522945426496 0.0152343334921861 no 106 0.0347443275202442 218 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_823 0417-1665 178 µM 1.81515331116601 0.0152376034245937 no 107 0.0347501762005102 292 3429856
SGTC_546 peri-Naphthalide 147 µM 1.81251894309594 0.0153511070664061 no 108 0.0349530248215186 270 223824 A penicillin ester.
SGTC_2919 7978188 46.38 µM 1.81042761053957 0.015441729866993 no 109 0.0351147503928744 282 2980291
SGTC_2505 galangin 7.89 µM 1.80603825153082 0.0156334265062119 no 110 0.035456182416255 213 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2445 5742597 35.57 µM 1.80357026601568 0.0157421050864349 no 111 0.0356493504303144 273 1774255
SGTC_2493 resveratrol 26.09 µM 1.79747154757986 0.0160134471962124 no 112 0.0361303955688725 218 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1413 3910-0535 34.4 µM 1.79294460128449 0.0162174419113023 no 113 0.0364908913427513 283 2876951
SGTC_606 k015-0008 38.6 µM 1.78624630012075 0.0165233650093221 no 114 0.037029693722648 313 1970475
SGTC_1529 apigenin 74 µM 1.78008959778514 0.0168088957954016 no 115 0.0375306493456395 325 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2963 9082507 9 µM 1.77318956019321 0.0171339054376946 no 116 0.0380986506905628 289 16459611
SGTC_283 0987-0079 11.7 µM 1.76374044372095 0.0175876852700286 no 117 0.0388878442955686 334 411556
SGTC_2918 7977171 22.06 µM 1.75148151391846 0.0181916565316399 no 118 0.03993150141627 287 2236483
SGTC_896 0964-0007 44.5 µM 1.746174197587 0.0184585688786438 no 119 0.0403903434673798 263 6756758
SGTC_1210 3013-0140 750 nM 1.73802789167159 0.0188747433441943 no 120 0.0411029496364203 291 905973
SGTC_1312 1218-2183 165 µM 1.7357607475427 0.0189919763114025 no 121 0.0413030736386143 298 6744073
SGTC_2398 5228213 48.84 µM 1.7314888443024 0.0192145576724721 no 122 0.0416823064353135 397 80771 YMR134W ERG29
SGTC_939 1165-0479 45.3 µM 1.72949327106637 0.019319291612665 no 123 0.0418604248841352 330 1377347
SGTC_1700 st030840 7.9285 µM 1.72180741281698 0.0197272133803122 no 124 0.0425522056630368 318 5499307
SGTC_33 0986-0033 35.816 µM 1.72087255497204 0.0197773255488621 no 125 0.0426369763956065 272 2848082
SGTC_249 wiskostatin 11.211 µM 1.7183716666105 0.0199119147409667 no 126 0.0428644224683059 286 2775510 A n-wasp and actin depolymerizer.
SGTC_1734 st037168 69.4 µM 1.716131297532 0.0200331428538293 no 127 0.0430690070406146 324 708907
SGTC_1204 4049-0315 18.3 µM 1.70973321381459 0.0203828003558455 no 128 0.0436576089706556 332 588402
SGTC_527 4476-4215 268 µM 1.70383313449279 0.0207098124844404 no 129 0.0442061329046143 336 4418754
SGTC_284 0988-0104 32.6 µM 1.69693375998299 0.0210978355362844 no 130 0.0448545922553926 307 4666532
SGTC_1602 st001878 87.6 µM 1.68995912722913 0.0214963254101586 no 131 0.0455178872148972 296 595405 YLR310C CDC25
SGTC_1482 3346-2049 8.48 µM 1.68665745958499 0.0216871709721396 no 132 0.0458346182129314 311 3826804
SGTC_1465 k213-0056 144 µM 1.67927629550331 0.0221190049387287 no 133 0.0465491042898698 322 24048857 YMR208W ERG12
SGTC_567 1080-0542 68.4 µM 1.67806179387597 0.0221907499153684 no 134 0.0466675181510168 292 5950415
SGTC_3306 9127676 59.7925 µM 1.67452764417466 0.0224006428915903 no 135 0.0470134730540517 334 41905287
SGTC_1132 3456-3614 2.5 µM 1.67380221894967 0.0224439323523998 no 136 0.0470847380593345 436 3125502
SGTC_2570 licareol 100 µM 1.65525648766091 0.0235748327198372 no 137 0.0489362406133065 342 443158
SGTC_2797 7859098 81.82 µM 1.65326254742802 0.0236992263870137 no 138 0.0491387208844562 362 972681
SGTC_3199 9111318 49.47 µM 1.64681558307454 0.0241052090876107 no 139 0.0497979786784951 348 8548020
SGTC_245 methotrexate 289.6 µM 1.642416377482 0.0243855796512484 no 140 0.0502518715646545 388 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1583 clindamycin 39.6 µM 1.63870931934704 0.0246239590124878 no 141 0.0506369061225464 330 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2518 prenyletin 46.28 µM 1.62926404553634 0.0252401811727958 no 142 0.0516285670129688 250 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1835 st008666 49.2 µM 1.62830836998197 0.0253032443852613 no 143 0.0517297578036544 287 690455
SGTC_2524 avocatin b 10.57 µM 1.62770248199964 0.025343294116411 no 144 0.0517939932883977 320 6710748
SGTC_1877 wortmannin 25 µM 1.61908017264301 0.0259190148451473 no 145 0.0527150071313292 440 312145 A covalent inhibitor of PI 3-kinase.
SGTC_37 0566-0070 1.56 µM 1.61176367733886 0.0264160892865362 no 146 0.0535066875255758 398 1626686
SGTC_539 4859-0462 2.54 µM 1.60406397954265 0.0269477765033413 no 147 0.0543499753285402 346 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2913 7966556 36.57 µM 1.60261292885499 0.0270489696798768 no 148 0.0545100687758495 326 2976516
SGTC_2439 5492030 7.2 µM 1.59885679209584 0.0273123884375265 no 149 0.0549262132896914 340 5722370
SGTC_632 0781-2353 4.65 µM 1.59528185000343 0.0275650839075469 no 150 0.0553246112242953 399 6811515 YHR007C ERG11
SGTC_530 4358-1714 28 µM 1.59015053897675 0.0279311954941128 no 151 0.0559004381739484 441 1564641
SGTC_559 1550-0661 158 µM 1.58537006584573 0.028275910932782 no 152 0.0564411391102841 364 5830875
SGTC_735 3076-0345 636 µM 1.58051457204283 0.0286296534693093 no 153 0.0569945362169555 435 2888990
SGTC_2647 atorvastatin 60.16 µM 1.58014644017038 0.0286566228236554 no 154 0.0570366670750694 371 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_564 3555-0129 330 µM 1.56727858617454 0.0296126819032503 no 155 0.0585247942203097 289 563260
SGTC_2443 5493264 126.67 µM 1.56330931379645 0.0299128801926874 no 156 0.0589899293294325 373 5340055
SGTC_1625 st003711 30.1 µM 1.55869762603794 0.0302648301962975 no 157 0.059533981965981 373 24207034 YER133W GLC7
SGTC_940 3232-1287 54.8 µM 1.54962170141453 0.0309675028630727 no 158 0.0606161705489967 397 1585493 YIL048W NEO1
SGTC_844 0330-0132 15.3 µM 1.5471760786403 0.0311591393123303 no 159 0.0609103963009948 387 2828079
SGTC_1624 st003710 6.25 µM 1.54551280712364 0.0312900311890865 no 160 0.0611111367538261 464 24207033
SGTC_2983 9022671 12.99 µM 1.54234813460747 0.0315403321731777 no 161 0.0614945089288118 371 6405161
SGTC_1039 k821-0043 94 µM 1.54095481909059 0.0316510561361581 no 162 0.0616638912456865 395 15992768
SGTC_385 1494-0393 12.4 µM 1.54016322921086 0.0317141051380283 no 163 0.0617602852379031 401 3090647
SGTC_657 3534-0529 86.7 µM 1.53915095128813 0.0317948827947425 no 164 0.0618837243465245 394 1049549
SGTC_3284 9108171 64.8615 µM 1.52481476317575 0.0329572412358542 no 165 0.0636526532814662 355 8687505
SGTC_1164 k060-0068 93.7 µM 1.52468934033322 0.032967562842811 no 166 0.06366830088579 446 5963676
SGTC_3203 9113543 49.47 µM 1.52167809998324 0.0332161721301617 no 167 0.0640448788086052 419 17018012
SGTC_1570 verbenone 133 µM 1.51271246145103 0.0339655368534412 no 168 0.0651763564171818 407 29025 A natural terpanoid with antifungal properties.
SGTC_644 1498-1197 63.3 µM 1.50236453589067 0.0348476630711048 no 169 0.066501495011095 446 6741615
SGTC_2381 9035592 200 µM 1.49436947370798 0.0355420215383893 no 170 0.0675395378623127 357 4749657
SGTC_1840 st055363 71 µM 1.4909124127269 0.0358457544758375 no 171 0.067992246015882 373 676033
SGTC_571 k831-0106 44.2 µM 1.49053422850667 0.0358791099196812 no 172 0.0680419117329058 392 4783639
SGTC_2255 7941087 197.44 µM 1.4903109725174 0.0358988127929209 no 173 0.0680712443688906 478 935561
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.48599403158243 0.0362815390308879 no 174 0.0686403498454464 454 1273210
SGTC_2678 equilin 100 µM 1.48573933557471 0.0363042235191321 no 175 0.068674040897244 436 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_930 2810-3379 265 µM 1.48536167833173 0.0363378809132712 no 176 0.0687240206680297 495 1015764
SGTC_1791 st048313 56.1 µM 1.48513242815071 0.0363583244965917 no 177 0.068754373686429 374 1204976
SGTC_1609 st001574 46.4 µM 1.48184922058113 0.0366521415402034 no 178 0.0691902095157548 433 3960012
SGTC_1142 3253-1408 9.78 µM 1.48054526124577 0.0367693715646991 no 179 0.069363895585982 412 256655
SGTC_212 3807-4682 38.772 µM 1.47292704736234 0.0374604161222459 no 180 0.0703853540075099 578 3125501 YBL034C STU1
SGTC_1272 0839-0021 27 µM 1.46901249369632 0.0378196077220356 no 181 0.070914700267106 452 5027250
SGTC_718 1130-0073 349 µM 1.46405000017778 0.0382789911842037 no 182 0.0715901436355084 457 6740020
SGTC_3065 9113888 49.47 µM 1.46233434581178 0.0384388656678342 no 183 0.0718248055415454 399 16648368
SGTC_587 k089-0003 57 µM 1.45973607333496 0.0386820234617205 no 184 0.0721813118429099 287 9659696
SGTC_2625 euphol 100 µM 1.45109903024708 0.0394993365616549 no 185 0.0733761432656302 498 6708538 A triterpene alcohol.
SGTC_1168 k815-0004 80.5 µM 1.44695229428387 0.0398966988287442 no 186 0.0739551426177469 460 642433
SGTC_2770 toltrazuril 17.5 µM 1.4460257980545 0.0399859232242578 no 187 0.0740849830433987 469 68591 Kills coccidiodes.
SGTC_465 cgp-37157 41 µM 1.4457879446402 0.040008855368598 no 188 0.0741183442153301 309 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1101 ebselen 5.29 µM 1.44511133776729 0.0400741474653443 no 189 0.0742133074268312 463 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_87 0100-0052 35.5 µM 1.44470716500922 0.0401131911447337 no 190 0.0742700782494454 684 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3032 9089427 49.47 µM 1.44453758627904 0.0401295818991617 no 191 0.074293907452981 422 17173707
SGTC_1982 st072467 71.9 µM 1.4444808432229 0.0401350676549673 no 192 0.0743018822908725 516 3163533
SGTC_1208 2323-2347 50.3 µM 1.43878973439253 0.0406883701138762 no 193 0.0751050528957068 436 5412760
SGTC_210 3551-0445 56.827 µM 1.43702088580049 0.0408615971639036 no 194 0.0753560295355609 469 2865180 YOR207C RET1
SGTC_791 1348-1292 225 µM 1.43684920931724 0.0408784416068558 no 195 0.0753804221914039 549 5437054
SGTC_74 000s-0487 160.283 µM 1.4337146754163 0.0411869853739931 no 196 0.0758268512658154 457 677548
SGTC_1034 k072-0165 12.7 µM 1.42849180027304 0.0417052842115427 no 197 0.0765751765402368 487 5835461
SGTC_972 1319-0219 195 µM 1.42822279977863 0.0417321212314119 no 198 0.0766138700701061 479 23903702
SGTC_2525 harmine 47.85 µM 1.42358879357803 0.0421966357425461 no 199 0.0772827708672278 393 5280953 A monoamine oxidase inhibitor
SGTC_150 3970-0969 77.2 µM 1.42204392731962 0.0423524204193738 no 200 0.0775067495749074 559 6615640
SGTC_505 gw-5074 63.9 µM 1.41783756511012 0.0427789500166276 no 201 0.0781190970091839 479 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_878 0828-0289 13.7 µM 1.41599132043072 0.0429672543998903 no 202 0.0783890228595054 540 745350 YLR208W SEC13
SGTC_324 1315-0088 19.6 µM 1.41239493250949 0.0433359842296359 no 203 0.0789168538674343 406 6787421
SGTC_1683 st010134 710 nM 1.41161929001328 0.0434158431577204 no 204 0.0790310447165689 468 3818134
SGTC_3103 9120822 49.47 µM 1.40913942253966 0.0436719638266767 no 205 0.0793969729225467 494 17141819
SGTC_3048 9093155 49.47 µM 1.4070521023835 0.0438884859610757 no 206 0.0797059697801703 401 25236002
SGTC_1136 pergolide 1.05886 µM 1.40539233020084 0.0440612749349747 no 207 0.0799523230965017 563 47811 A dopamine receptor agonist.
SGTC_797 k781-0471 270 µM 1.40045807265503 0.0445781921658145 no 208 0.080688095165931 475 23738129
SGTC_99 0109-0120 622.8 µM 1.39737339104861 0.0449038201655122 no 209 0.0811506582556309 433 759414
SGTC_3125 9127534 49.47 µM 1.39597841657068 0.0450517051907679 no 210 0.0813604973778453 367 1639235
SGTC_1383 3049-0032 20.7 µM 1.39520966276782 0.0451333702418601 no 211 0.0814763120076826 494 712864
SGTC_1717 st033143 58.0435 µM 1.39248788910655 0.0454234633467451 no 212 0.0818873532603247 537 674616
SGTC_875 0709-0210 25.7 µM 1.39232436699113 0.0454409395652738 no 213 0.0819120979844297 535 6251364
SGTC_56 0957-0365 83.25 µM 1.39068970600316 0.0456159392539663 no 214 0.0821597702518198 505 6752360
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.38558081000312 0.0461663706763591 no 215 0.0829374706366188 446 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.37901116985485 0.0468820085120069 no 216 0.0839456550087366 473 689007
SGTC_897 1000-0139 31.4 µM 1.3731223335477 0.0475310226223335 no 217 0.0848571595638973 488 6151020
SGTC_634 1611-4317 11.2 µM 1.36945972155139 0.0479382996655806 no 218 0.0854278085297954 545 2843522
SGTC_1565 sinapyl alcohol 95.1 µM 1.3625040546184 0.0487194465363826 no 219 0.0865194327161964 477 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1008 4106-0037 6 µM 1.35806024911916 0.0492238059639248 no 220 0.08722228361944 481 2905394
SGTC_2819 7996655 46.38 µM 1.35796350365918 0.0492348325020031 no 221 0.0872376325644771 436 6456960
SGTC_3094 9117742 49.47 µM 1.35602054859574 0.0494566981542515 no 222 0.0875463150647248 533 17149698
SGTC_2295 7971645 200 µM 1.35263145639611 0.0498456073466963 no 223 0.0880866989481912 516 2978226 YKL099C UTP11
SGTC_2564 betulinic acid 100 µM 1.34826004290132 0.0503508391610092 no 224 0.0887873794100528 567 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2681 menadione 3.18 µM 1.34661225599099 0.0505423400791667 no 225 0.0890525724121706 517 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1344 1488-0097 29.1 µM 1.34470538145673 0.0507646751393388 no 226 0.0893601980470935 514 747966
SGTC_440 fluspirilene 35.1 µM 1.34382241961268 0.0508678889420935 no 227 0.0895029089268623 533 3396 An atypical antipsychotic.
SGTC_1103 duloxetine 36.1 µM 1.34117936273527 0.0511778478556851 no 228 0.0899311125396691 579 60835 A selective serotonin reuptake inhibitor.
SGTC_2290 7904846 200 µM 1.33437955698448 0.0519821897327273 no 229 0.0910397481642159 530 2962154
SGTC_2128 5255449 168.493 µM 1.33416134892949 0.0520081667178095 no 230 0.0910754917786471 553 736008
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.33327942080815 0.0521132625917886 no 231 0.0912200622409565 557 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1739 st037196 92.5 µM 1.33179960444679 0.0522899853700099 no 232 0.0914630239949815 550 612214
SGTC_672 1441-0018 53.7 µM 1.33163891260701 0.0523092041364557 no 233 0.0914894358210786 491 251141
SGTC_3247 9135149 49.47 µM 1.32885631222213 0.052642893841817 no 234 0.0919476897771255 465 8934436 YOR116C RPO31
SGTC_2450 5739737 12.93 µM 1.32673269539404 0.0528986929371196 no 235 0.0922985607134285 501 2262825
SGTC_1224 0823-0416 294 µM 1.32470043335591 0.0531444101924708 no 236 0.0926352646941267 524 3598164
SGTC_3101 9120531 49.47 µM 1.32258711010143 0.0534008873134058 no 237 0.0929863615679199 546 24824904
SGTC_2921 7974240 10.71 µM 1.31264774506056 0.0546203287525966 no 238 0.0946508366264216 541 2979074 YDR527W RBA50
SGTC_2252 omeprazole 400 µM 1.31018635708039 0.0549256878576957 no 239 0.0950663999462496 421 4594 A proton pump inhibitor.
SGTC_2837 9008476 45.46 µM 1.30543450286482 0.0555190166600631 no 240 0.095872468067644 566 2992805
SGTC_3301 9125354 19.7965 µM 1.3001639161345 0.056183021881012 no 241 0.0967723975012112 486 41905162
SGTC_1511 0906-3109 28.5 µM 1.29863046345033 0.0563773825243269 no 242 0.0970353891121533 646 2882180
SGTC_1427 4048-4900 550 nM 1.29839445541034 0.0564073428570736 no 243 0.0970759117200047 544 24132586
SGTC_2679 rapamycin 1 nM 1.2966945010361 0.0566235165519838 no 244 0.0973681610780131 650 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1322 1348-1070 12 µM 1.29655357454765 0.0566414666435311 no 245 0.097392417536604 501 6758089
SGTC_3261 9137475 49.47 µM 1.29603935022122 0.0567070024608761 no 246 0.0974809641234096 332 17027690
SGTC_1345 1488-0192 31.4 µM 1.29386233246482 0.0569851165666499 no 247 0.0978564887217478 557 658348
SGTC_1991 st073000 8.92 µM 1.29273533742915 0.0571295115107282 no 248 0.0980513057250353 615 4301969 YIL048W NEO1
SGTC_1256 0570-0116 285 µM 1.2874420616858 0.0578115629921474 no 249 0.0989701258575789 521 410638
SGTC_959 1222-0044 107 µM 1.28700527092646 0.057868129259123 no 250 0.099046225484116 556 6083612
SGTC_3024 9090631 49.47 µM 1.2866233225013 0.0579176288593829 no 251 0.0991128053049053 506 25236383
SGTC_1412 3909-8563 178 µM 1.28606414933842 0.0579901563820326 no 252 0.0992103373088406 615 23767530
SGTC_697 0508-1955 564 µM 1.28523942042965 0.0580972580531333 no 253 0.0993543160943986 605 6243113
SGTC_2763 lisinopril 49.32 µM 1.28476389023344 0.058159082384475 no 254 0.099437402178646 510 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3059 1327-0034 3 µM 1.28456347189858 0.0581851545252768 no 255 0.0994724350897709 560 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_164 4100-3994 89.624 µM 1.28421916563492 0.0582299662825134 no 256 0.0995326405170728 632 4615967
SGTC_2820 7989630 71.43 µM 1.28151595311932 0.0585827343954304 no 257 0.100006250063854 448 2984098
SGTC_2807 7945238 51.95 µM 1.2813462324223 0.058604938733279 no 258 0.100036040361914 571 17148797
SGTC_451 chloral hydrate 100 µM 1.27610448187372 0.0592939687256665 no 259 0.100959293746889 640 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_253 dyclonine 31.25 µM 1.27412316180398 0.0595560622013552 no 260 0.101309885532706 612 3180 An oral anasthetic.
SGTC_2954 9074818 52.69 µM 1.27219665736315 0.0598117743273385 no 261 0.101651627494402 558 16648742
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.27099159327088 0.0599721637370322 no 262 0.101865819691123 411 88881 An O-methylated flavonoid and antioxidant.
SGTC_273 hydroxyurea 18.1 mM 1.26951740305802 0.0601688306413258 no 263 0.102128293784978 640 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1351 1496-0003 46.5 µM 1.26763078858096 0.0604212538361417 no 264 0.102464915791566 583 3891978
SGTC_2167 5876490 200 µM 1.26498408389529 0.0607767705599353 no 265 0.102938516704753 570 686534
SGTC_352 k048-0007 5.11 µM 1.26144295130761 0.0612549867069564 no 266 0.103574650860305 640 6811911
SGTC_2047 4141938 200 µM 1.26058151635763 0.0613717635844779 no 267 0.103729830762526 516 3807862
SGTC_2914 7968218 45.32 µM 1.25730919431864 0.0618169481563801 no 268 0.104320847973916 531 2977111
SGTC_1876 myriocin 605 nM 1.25666324975882 0.0619051231558583 no 269 0.104437800486267 565 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2004 4023728 41.89 µM 1.25532847111332 0.0620876387750844 no 270 0.104679771866926 595 360084 YDR527W RBA50
SGTC_2821 7996764 71.43 µM 1.25194499263458 0.0625521715331736 no 271 0.105294954265389 612 2987135
SGTC_2796 7949634 45.45 µM 1.25130711632068 0.0626400511769191 no 272 0.10541122506914 556 2971588
SGTC_1453 4237-0541 195 µM 1.24949709251139 0.0628899405149965 no 273 0.105741658133653 588 739892
SGTC_2282 7944268 200 µM 1.24826193691314 0.0630609097120228 no 274 0.105967574238497 610 2970414
SGTC_2207 7258803 200 µM 1.24670285034688 0.0632772337668284 no 275 0.106253236656273 523 3666799
SGTC_981 1488-1094 54.9 µM 1.23826579719992 0.0644579169062829 no 276 0.107808760750011 524 3449522
SGTC_770 0389-1121 67.2 µM 1.22492469428931 0.0663597144845894 no 277 0.110301797607669 656 6753108
SGTC_3336 9143619 71.43 µM 1.22425523460884 0.0664562799239459 no 278 0.110427979205956 646 45595730
SGTC_724 3910-0327 137 µM 1.22269899448902 0.0666811783579494 no 279 0.110721703456386 615 2885483
SGTC_3289 9119912 71.43 µM 1.22007443702886 0.0670617972848536 no 280 0.111218329058942 589 17014829
SGTC_129 0088-0017 176.636 µM 1.21817705666172 0.0673380042693312 no 281 0.11157834820232 571 182446
SGTC_3328 9140624 29.0385 µM 1.21796160636084 0.0673694234899658 no 282 0.111619281558294 633 4904392
SGTC_1254 0550-0035 264 µM 1.21752195513572 0.0674335731919158 no 283 0.111702844128146 647 15121435
SGTC_1874 staurosporine 7.6 µM 1.21647402718594 0.0675866671805062 no 284 0.111902199604774 630 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2886 9058944 51.95 µM 1.21517343902945 0.0677770461471483 no 285 0.112149974262452 424 4949929
SGTC_2988 9073640 71.4286 µM 1.21378835950529 0.0679802480554114 no 286 0.112414276268747 566 9102229
SGTC_2791 5663188 71.43 µM 1.21369926018692 0.0679933357021006 no 287 0.112431293494886 564 54690634
SGTC_2362 9071156 126 µM 1.21349006410679 0.0680240718030662 no 288 0.112471255433252 598 653133
SGTC_621 3584-0052 32.1 µM 1.21348796647476 0.0680243800516316 no 289 0.112471656187364 632 2273927
SGTC_3207 9114163 49.47 µM 1.2102980841548 0.068494384603809 no 290 0.113082266285309 679 849233
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.2076223222067 0.0688905662015935 no 291 0.113596284487288 617 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2380 9035439 200 µM 1.20564528253879 0.0691844259140461 no 292 0.113977145633175 659 6462575
SGTC_1526 st051518 75 µM 1.20430850676396 0.0693836658689847 no 293 0.114235179978502 576 673993
SGTC_1644 st010134 20.9 µM 1.20387730566164 0.0694480284870049 no 294 0.114318502275372 573 3818134
SGTC_1118 chelidonine 707.474 nM 1.1934932018252 0.0710119220125025 no 295 0.116338136504398 684 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3323 9138564 53.9225 µM 1.19272236901487 0.0711290827766228 no 296 0.116489061030645 690 43912313 YNL103W MET4
SGTC_611 3453-1652 23.7 µM 1.19078982283195 0.0714234677163922 no 297 0.116868052582535 668 1560575
SGTC_153 4077-0274 519.67 µM 1.19026594709926 0.0715034306338124 no 298 0.116970940236423 580 3121976
SGTC_330 1488-0319 80.1 µM 1.18920655105952 0.0716653437701916 no 299 0.117179198625918 633 6846614
SGTC_2225 6654152 15.4 µM 1.1884176483907 0.0717860985676538 no 300 0.117334453377499 551 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1821 st053465 65.6 µM 1.18691443853164 0.0720166219798126 no 301 0.117630685752451 596 675086
SGTC_1748 st037455 53.6035 µM 1.18674607649835 0.0720424762930498 no 302 0.117663897214476 632 580690
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.18059499607102 0.0729919467284561 no 303 0.118881826214688 460 6708630 An antioxidant.
SGTC_1270 0831-1170 17.3 µM 1.18022069648144 0.0730500306558926 no 304 0.118956224779072 703 6764716
SGTC_2975 9084847 53.72 µM 1.17654836945074 0.0736217809425428 no 305 0.119687907837425 655 27211724
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.17402914867914 0.0740159765891907 no 306 0.120191675235155 614 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1561 5-methoxyflavone 52.9 µM 1.17362936338713 0.074078681066801 no 307 0.120271757269707 576 94525
SGTC_2060 5238662 140 µM 1.17344756465864 0.07410720877752 no 308 0.120308186278122 604 790130
SGTC_1386 3228-0095 33.8 µM 1.16373248395227 0.0756439298786908 no 309 0.122266220402806 642 870181
SGTC_1041 0206-0046 107 µM 1.16293477748267 0.0757711808537653 no 310 0.122427982966708 646 50494
SGTC_2973 9094665 17.96 µM 1.16025539114974 0.0761997931094262 no 311 0.122972420421403 716 25237061 YIL048W NEO1
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.15898581189687 0.0764035265784759 no 312 0.123230984189292 686 165521
SGTC_3240 9133527 49.47 µM 1.15837605453158 0.0765015235100066 no 313 0.123355303312739 646 17617455
SGTC_3155 9099265 49.47 µM 1.15646918530543 0.0768086023862262 no 314 0.123744648369285 609 25236499
SGTC_3069 9117009 49.47 µM 1.15491014197663 0.0770603635950583 no 315 0.12406361288571 521 41904981
SGTC_2970 9090938 41.86 µM 1.15397691806782 0.077211364484595 no 316 0.124254816079983 736 17217104
SGTC_357 1325-0123 420 µM 1.1505979521005 0.0777599811542715 no 317 0.124948837948638 632 1098503
SGTC_2752 diclazuril 33.15 µM 1.14608493974935 0.0784973327935306 no 318 0.125880004201324 836 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_79 0052-0007 94.094 µM 1.14608325649248 0.0784976087952754 no 319 0.125880352406849 676 2801472
SGTC_3179 9107801 49.47 µM 1.14269973473285 0.0790538893689223 no 320 0.126581639992607 669 4818259
SGTC_1040 k898-0338 155 µM 1.14177358951089 0.0792066749644936 no 321 0.126774071489685 724 20969351
SGTC_1795 st049545 62.3 µM 1.1415655743919 0.0792410218144856 no 322 0.126817320204368 647 5291882
SGTC_605 1315-0399 119 µM 1.13785486331869 0.079855619854959 no 323 0.127590545720902 716 24020461
SGTC_2748 diazoxide 86.69 µM 1.13649379159554 0.0800819530118679 no 324 0.127874981206596 612 3019 A potassium channel activatior.
SGTC_1216 1165-0504 9.65 µM 1.13124741595794 0.0809589136945089 no 325 0.1289754849294 702 6304004
SGTC_2087 5276107 200 µM 1.13081828771579 0.0810309643171777 no 326 0.129065790542583 679 144405
SGTC_2102 5377816 72.7585 µM 1.12039566486936 0.0827958190190276 no 327 0.131272595745475 720 1379702
SGTC_2845 9003024 42.97 µM 1.11926323192392 0.0829893016451829 no 328 0.131513928361127 697 2990173
SGTC_1988 st071872 53.4 µM 1.11900424449992 0.0830335988688971 no 329 0.131569164134408 701 16414116
SGTC_3292 9120825 59.784 µM 1.11778549298222 0.0832422929726517 no 330 0.131829309405177 703 24824900
SGTC_2488 5268135 45.7 µM 1.11518664109696 0.0836886266009691 no 331 0.132385224742204 777 1270356 YLR208W SEC13
SGTC_2474 5321570 43.32 µM 1.11492736783161 0.0837332533138696 no 332 0.132440773879733 671 2841384
SGTC_1296 1068-0102 11.9 µM 1.11155976375612 0.0843145181356729 no 333 0.133163740299328 697 767053
SGTC_2221 6807166 181.081 µM 1.11114843509525 0.0843857224719216 no 334 0.133252231229049 619 674925
SGTC_832 4083-0019 164 µM 1.11071330481865 0.0844610961641295 no 335 0.133345886737097 893 1990758
SGTC_362 0310-0100 9.03 µM 1.11006913462616 0.0845727726764845 no 336 0.133484618194819 664 790235
SGTC_1329 1447-1697 50.6 µM 1.11000470142519 0.0845839492238021 no 337 0.133498500284961 695 2840515
SGTC_779 1360-0071 233 µM 1.10787806653988 0.0849534561501741 no 338 0.133957239622594 761 7566
SGTC_2669 eugenol 100 µM 1.10746596030733 0.0850252001562381 no 339 0.134046260772942 638 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_312 4092-0653 6.84 µM 1.10716912892052 0.0850769039716443 no 340 0.134110405997836 793 1148278
SGTC_1246 0422-0085 105 µM 1.10092973412456 0.0861691782607745 no 341 0.13546361990909 736 264295
SGTC_1432 4049-0298 68.4 µM 1.10036610949461 0.0862683611581408 no 342 0.135586319255613 685 741646
SGTC_1911 st060208 74.3 µM 1.09872328163991 0.0865579421423891 no 343 0.135944392142054 739 688783
SGTC_1636 st007707 68.9 µM 1.09815263988669 0.0866586989153504 no 344 0.13606892132668 750 403051
SGTC_1255 0566-0045 221 µM 1.09388935028846 0.0874142326097778 no 345 0.137001755038873 708 2788469
SGTC_625 k213-0058 121 µM 1.08693081991245 0.088657957860829 no 346 0.138533692226802 891 3655420
SGTC_1346 1488-2224 62.4 µM 1.08468853666472 0.0890615245277512 no 347 0.139029813355644 742 3722427
SGTC_784 4579-0127 173 µM 1.08365449601877 0.089248091390501 no 348 0.139259009210618 759 1948547
SGTC_631 k072-0230 41.5 µM 1.08215044211158 0.0895199792993844 no 349 0.139592842572091 771 5773147
SGTC_2915 7971052 15.16 µM 1.08214973404573 0.0895201074413892 no 350 0.139592999859405 555 5741558
SGTC_2523 spermine 47.74 µM 1.08178230913077 0.0895866204582946 no 351 0.139674634624702 706 1103 A DNA binding polyamine.
SGTC_1921 5740136 50 µM 1.08137009847617 0.0896612845363403 no 352 0.139766258551023 780 1774243
SGTC_3265 9137266 49.47 µM 1.08016812733161 0.0898792627624566 no 353 0.14003365934872 682 17224265
SGTC_1752 st044819 83.042 µM 1.07874708922101 0.0901374767075808 no 354 0.140350243809272 684 441209 YML126C ERG13
SGTC_1833 st055984 71 µM 1.07680848348283 0.0904906249866134 no 355 0.140782917271948 722 676288
SGTC_2629 bisabolol 100 µM 1.0746715696393 0.0908810873642064 no 356 0.141260898343427 754 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2806 7952793 58.44 µM 1.07246540428405 0.0912855135692238 no 357 0.14175552240561 744 2972490
SGTC_2275 7947463 200 µM 1.06908451646073 0.0919078725499422 no 358 0.142515793940578 695 1225414
SGTC_168 3970-0862 530.542 µM 1.06853378491619 0.092009548985013 no 359 0.142639899494367 880 3135186
SGTC_3039 9090270 49.47 µM 1.06785613678368 0.0921347711131141 no 360 0.142792705534699 690 17173750
SGTC_2721 ifenprodil 61.44 µM 1.06678464793744 0.0923330281908639 no 361 0.14303454628885 735 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_907 3448-6986 75.5 µM 1.06576808845714 0.0925214134048787 no 362 0.143264244879065 806 590582
SGTC_3305 9127027 53.8275 µM 1.06328848654175 0.0929821169431953 no 363 0.143825572411403 740 41905295
SGTC_2980 9014342 25.29 µM 1.06246275906046 0.0931359107153893 no 364 0.144012827906635 693 2996599
SGTC_1798 st045719 60.953 µM 1.05828358303848 0.0939171768278727 no 365 0.144963087599867 704 3980186
SGTC_1655 st012546 55.1 µM 1.05160845006748 0.0951750592301727 no 366 0.146489614648377 719 720985 YLR208W SEC13
SGTC_147 4466-0538 29.23 µM 1.05059659769338 0.0953668136035775 no 367 0.146721952176558 767 6742687 YHR072W ERG7
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.04924089289533 0.0956241764464937 no 368 0.147033631089597 745 6312947
SGTC_2519 cryptotanshinone 88.04 µM 1.04713090867996 0.0960257454899893 no 369 0.147519602788439 753 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.0455772681003 0.096322223763834 no 370 0.147878124512084 779 688667
SGTC_2808 7946468 45.46 µM 1.04539344939171 0.0963573459959555 no 371 0.147920581505406 783 2970879
SGTC_2066 5222451 176 µM 1.04420287835358 0.0965850562592781 no 372 0.148195767773135 812 2281147
SGTC_419 nsc-638432 893 µM 1.04269405990012 0.0968742025737771 no 373 0.148545004943873 756 368090
SGTC_308 4092-1169 104 µM 1.04200425922048 0.0970066058069327 no 374 0.148704852129509 798 2268590 YDL196W YDL196W
SGTC_1140 3229-1848 2.98 µM 1.04166364275491 0.0970720341294353 no 375 0.148783825411007 776 2849525
SGTC_1755 st041960 45.185 µM 1.04092298696285 0.0972144169697846 no 376 0.148955646126977 760 2257073
SGTC_179 1273-0063 6.77 µM 1.04080229083259 0.0972376339727156 no 377 0.148983658323828 707 3108139
SGTC_1787 fluconazole 80 µM 1.03984748973772 0.0974214420963621 no 378 0.149205380817716 795 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2020 4017018 200 µM 1.03899733906546 0.0975853184207486 no 379 0.149402986904163 755 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2337 9009472 200 µM 1.03760787194774 0.0978535892306475 no 380 0.14972632577431 787 5742383
SGTC_899 1083-0020 478 µM 1.03680991078729 0.0980078994236324 no 381 0.1499122278856 790 767123
SGTC_2532 xanthone 78.9 µM 1.0364295082066 0.0980815246291105 no 382 0.150000904957988 693 7020 An insecticide.
SGTC_2402 5553605 200 µM 1.03392847394391 0.0985665978253138 no 383 0.150584801226157 798 6758546
SGTC_445 e6 berbamine 66 µM 1.0305113399266 0.0992321833861919 no 384 0.151385015874904 874 6610268 A calcium/calmodulin antagonist.
SGTC_2288 7946289 167.31 µM 1.02936438583776 0.0994563208422172 no 385 0.151654239016551 839 1246052
SGTC_1714 st033236 13.627 µM 1.02706112241153 0.0999075412061756 no 386 0.15219584188769 778 2916566
SGTC_376 3970-0862 59.1 µM 1.0236182125326 0.100584808794601 no 387 0.153007819739046 808 3135186
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.0226493808966 0.100775993718579 no 388 0.153236826363795 718 521171
SGTC_2670 beta-carotene 100 µM 1.01952264419166 0.101394817518042 no 389 0.153977454245355 716 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3060 1327-0027 12.5 µM 1.01729477798328 0.101837428334914 no 390 0.154506610027238 751 16000455 YPR107C YTH1
SGTC_105 0111-0055 734.78 µM 1.01516382550289 0.102262099609522 no 391 0.155013870593397 688 5179370
SGTC_1291 0993-0025 5.79 µM 1.01219314970908 0.102856264219789 no 392 0.155722855462216 812 4353356
SGTC_1498 4478-3555 97.6 µM 1.00963615254096 0.103369694405658 no 393 0.15633482109456 761 3437919
SGTC_2866 9034245 58.44 µM 1.00953409608148 0.103390225291714 no 394 0.156359279075699 780 6462273
SGTC_2638 epoxomicin 18 µM 1.00878784573601 0.103540439811045 no 395 0.156538195655444 830 9915668 A protesome inhibitor.
SGTC_1574 spiramycin 23.7 µM 1.00821428543815 0.103656000738998 no 396 0.15667580066597 788 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3177 9107506 49.47 µM 1.00747899510511 0.103804283880837 no 397 0.156852323364938 765 8897194
SGTC_3223 9129970 49.47 µM 1.00676278877078 0.103948866301157 no 398 0.157024390293986 816 17248386
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.00643710773678 0.104014660653724 no 399 0.157102675466547 807 5282309
SGTC_1320 1313-0481 95.3 µM 1.00429514996484 0.104448133235817 no 400 0.157618185351549 838 6813365 YLR208W SEC13
SGTC_386 1509-0011 3.07 µM 1.00205768300374 0.104902330385675 no 401 0.158157867143053 871 3107280
SGTC_2476 5806916 10.51 µM 1.00171769700069 0.104971471189857 no 402 0.158239978508772 774 2870194
SGTC_1371 2421-0008 32.7 µM 1.00167218099021 0.104980729996404 no 403 0.158250973383542 762 2827552
SGTC_2073 5212005 126 µM 1.00035357634012 0.105249215493702 no 404 0.158569713933399 713 691789
SGTC_272 doxorubicin 8.13 µM 1.0003228970914 0.105255468106636 no 405 0.158577134902547 833 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_886 0866-0150 153 µM 0.995700859876884 0.10620053938482 no 406 0.159697756099721 860 271463
SGTC_910 3454-3003 490 µM 0.994145399376048 0.106519959866695 no 407 0.160076042798923 829 820824
SGTC_1170 0310-0127 64.8 µM 0.993027024017501 0.106750051268942 no 408 0.160348392532218 833 774975
SGTC_1340 1486-1359 257 µM 0.991204750922385 0.107125728558463 no 409 0.160792805595063 815 4309068
SGTC_1898 st060199 18.6 µM 0.989515105590793 0.107474914518089 no 410 0.161205591469094 789 688866
SGTC_2742 clothiapine 36.27 µM 0.988341875161877 0.107717859075402 no 411 0.161492621819136 761 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1800 st050079 29.0735 µM 0.982089323902087 0.109019268480239 no 412 0.163027922295914 914 3645560
SGTC_908 3448-7491 47.7 µM 0.977772732723601 0.109924295971242 no 413 0.164093369943835 877 1203031
SGTC_450 aminopyrene 156 nM 0.976104635586858 0.110275473808788 no 414 0.164506307209328 824 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2884 9058502 51.95 µM 0.975641449596415 0.110373129079088 no 415 0.164621088219019 820 6471554
SGTC_2057 5236571 38.335 µM 0.975461321891387 0.110411122832041 no 416 0.164665739244998 855 54684039 YBR257W POP4
SGTC_798 1287-0182 476 µM 0.973561296691337 0.110812460217505 no 417 0.165137205599692 914 1649755
SGTC_2374 9071832 200 µM 0.969665938476719 0.111638532309656 no 418 0.166106516922016 820 17381698
SGTC_468 gf-109203x 121 µM 0.968227137600646 0.111944764139362 no 419 0.166465472299997 708 2396 A protein kinase C inhibitor.
SGTC_2546 rhodinyl acetate 100 µM 0.967744071419431 0.112047713650896 no 420 0.16658610097992 870 6708682
SGTC_470 aa-861 153 µM 0.967702401813614 0.112056597313442 no 421 0.166596509131669 840 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3157 9099274 49.47 µM 0.966637599987811 0.112283776316927 no 422 0.166862615614533 826 17217662
SGTC_2094 5332512 191.667 µM 0.965638597694208 0.112497215850257 no 423 0.1671125271821 882 755774
SGTC_1379 2144-0755 36.5 µM 0.965277867541352 0.112574357996888 no 424 0.167202827126687 899 5392327
SGTC_2378 9074213 121.43 µM 0.962844703369981 0.113095677192206 no 425 0.167812731503626 836 657714
SGTC_3012 9080433 71.4286 µM 0.96271919234202 0.113122615287114 no 426 0.167844231283387 878 17688859
SGTC_1760 st045453 10.4495 µM 0.961109534157641 0.113468497838788 no 427 0.168248548178858 883 3323419 YIL048W NEO1
SGTC_2313 7726885 200 µM 0.960202517106072 0.113663729099477 no 428 0.168476650137099 807 726423
SGTC_1822 st052468 42 µM 0.958677655295369 0.113992488082597 no 429 0.168860579232672 821 2873678
SGTC_822 1487-0950 154 µM 0.958507961149582 0.114029115852624 no 430 0.168903339487898 859 1958375
SGTC_2626 ethyl orsellinate 100 µM 0.957516143968965 0.114243363149297 no 431 0.169153400944377 810 75653 A natural product.
SGTC_679 0422-0091 41.4 µM 0.957056596167255 0.114342729448829 no 432 0.169269344772688 877 627384 YHR062C RPP1
SGTC_2648 atorvastatin 78.68 µM 0.956632575701494 0.114434468376094 no 433 0.169376370303071 830 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2466 5983409 37.09 µM 0.956167121677622 0.114535231973431 no 434 0.169493903927193 815 2879657
SGTC_2773 thioridazine 9.09 µM 0.954901877434648 0.114809456891425 no 435 0.169813660127394 887 5452 An antipsychotic.
SGTC_3007 9078383 71.4286 µM 0.952134457992145 0.1154108857098 no 436 0.170514397763088 850 6496995
SGTC_1855 st056195 39.6 µM 0.95202140639839 0.115435502133764 no 437 0.17054306284055 815 4028379
SGTC_1647 st011722 22.4 µM 0.946630514875964 0.116613675914585 no 438 0.17191354446904 817 2854783
SGTC_2044 5102272 200 µM 0.939362349527672 0.118215587757511 no 439 0.173772368391311 779 592666
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.938327425660944 0.11844494564428 no 440 0.174038084836401 858 756377
SGTC_1460 k062-0059 9.15 µM 0.938152913306464 0.11848365171411 no 441 0.17408291627722 828 1373085
SGTC_2277 7947813 106.88 µM 0.937660912859383 0.118592823367984 no 442 0.174209348503248 831 1246798
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.934166806317897 0.11937018769992 no 443 0.17510892762399 944 368090
SGTC_887 0885-0007 9.62 µM 0.933696051385004 0.119475194873234 no 444 0.175230351211433 887 5719458
SGTC_1237 0330-0133 46.1 µM 0.933308234338224 0.119561750765511 no 445 0.17533042242219 831 X1237 YHR072W ERG7
SGTC_132 0417-1715 25.805 µM 0.933295858634747 0.119564513595146 no 446 0.175333616410102 899 6769098
SGTC_444 curcumin 90.4 µM 0.932035256231114 0.119846174342328 no 447 0.175659152692137 855 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2603 homopterocarpin 100 µM 0.930658981201666 0.120154214025399 no 448 0.176014997108676 861 101795 A weak amylase inhibitor.
SGTC_319 1348-1596 45.5 µM 0.930555219423094 0.120177460719213 no 449 0.176041843847654 908 5380505
SGTC_630 4356-0227 183 µM 0.926694627368512 0.121044637599559 no 450 0.177042553910494 849 779312
SGTC_2739 tacrine 100.86 µM 0.926373213407467 0.12111703249927 no 451 0.177126029880323 833 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_633 0437-0093 97.7 µM 0.92614823256174 0.121167725036176 no 452 0.177184475530845 882 2831118
SGTC_2995 9067767 71.4286 µM 0.924942310739588 0.121439696925433 no 453 0.177497958171012 814 11673567
SGTC_853 0419-0306 21 µM 0.919516671263818 0.122668651211498 no 454 0.178912694868962 805 762713
SGTC_161 4065-0411 162.148 µM 0.918407071470619 0.122921055942773 no 455 0.17920289496777 903 1906281 YLR208W SEC13
SGTC_2711 st079103 59.1 µM 0.918315705983346 0.122941855399676 no 456 0.179226803501446 880 54693780
SGTC_1741 st038134 10.228 µM 0.918192298144243 0.122969953251616 no 457 0.179259100067031 947 1272587
SGTC_29 0299-0004 12.984 µM 0.91702060457215 0.123236952123994 no 458 0.179565921564392 790 16871 A napthoquinone isolated from Swertia calycina.
SGTC_104 0074-0074 590.992 µM 0.908781370586645 0.125125935531656 no 459 0.181732771056482 760 3943124
SGTC_2691 st077356 60.2 µM 0.908681170660541 0.125149031829114 no 460 0.181759223079944 941 2839272
SGTC_725 1497-0963 19 µM 0.906453624544861 0.12566325487908 no 461 0.182347900289293 930 3549977
SGTC_8 0354-0001 70 µM 0.905220996363103 0.125948436491799 no 462 0.18267416033215 980 4993152
SGTC_1578 josamycin 24.2 µM 0.903147026643167 0.126429289282681 no 463 0.183223934098453 829 5282165 A P450 substrate.
SGTC_3237 9133362 49.47 µM 0.894099251063449 0.128541982963928 no 464 0.185634394995077 915 43845137
SGTC_1648 st011736 69.8 µM 0.89165619700504 0.12911662374912 no 465 0.186288619322034 901 2855514
SGTC_1151 3909-8316 15.3 µM 0.889681588998946 0.129582379111106 no 466 0.18681844130792 914 800431
SGTC_176 1486-1328 72.834 µM 0.886621575093113 0.130306448641668 no 467 0.187641337045942 950 22310231
SGTC_1736 st036774 51 µM 0.886236630291805 0.130397733231942 no 468 0.187745014340613 972 1272247
SGTC_462 ag-879 158 µM 0.885029031410322 0.130684386394039 no 469 0.188070486839663 965 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_986 1493-0483 84 µM 0.882898543043299 0.131191171595769 no 470 0.188645545440212 909 40079
SGTC_1378 2093-0007 380 nM 0.881652809894339 0.131488125698201 no 471 0.188982293743932 903 3618014
SGTC_326 k292-0812 17.5 µM 0.881369046975064 0.131555833079356 no 472 0.189059052679637 932 3579357
SGTC_3026 9090633 49.47 µM 0.881117383318462 0.131615901533214 no 473 0.189127144709061 949 25236842
SGTC_1531 st059297 52.4 µM 0.880913069136468 0.131664682276137 no 474 0.189182436611542 939 7566702
SGTC_1929 genistein trimethyl ether 50.5 µM 0.880430882625023 0.131779855496475 no 475 0.1893129663253 951 136420
SGTC_3124 9127567 49.47 µM 0.880196980135334 0.131835749577917 no 476 0.189376304579298 910 17592030
SGTC_490 phenamil 164 µM 0.879824754960781 0.131924731405811 no 477 0.189477126004139 852 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2700 st077718 96.8 µM 0.879744877647995 0.131943831775246 no 478 0.189498765987229 870 904970
SGTC_1418 3966-3099 2.4 µM 0.874476327981534 0.133207867909509 no 479 0.19092945308137 945 740335
SGTC_1971 st069429 63.5 µM 0.873218142770418 0.13351096163617 no 480 0.191272093861073 973 1246522 YGL099W LSG1
SGTC_394 menadione 8.33 µM 0.872408437542949 0.13370626828567 no 481 0.191492799575515 947 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2307 7538926 6.34 µM 0.87085442547314 0.134081657056678 no 482 0.191916821882326 944 96582
SGTC_732 3970-1727 52.7 µM 0.870646014046097 0.134132056148902 no 483 0.191973731971207 952 1275699
SGTC_994 3910-0338 138 µM 0.869743128873114 0.134350546654996 no 484 0.192220398551182 975 3479481
SGTC_2834 9001755 58.44 µM 0.867959301758724 0.134782935678791 no 485 0.192708306430718 877 2989575
SGTC_2946 9065502 71.43 µM 0.86713012580222 0.134984247687269 no 486 0.192935357945394 787 16489101
SGTC_1257 0669-0121 16 µM 0.863296284949629 0.135917729704892 no 487 0.193987293130933 1048 4307855
SGTC_325 2810-4341 181 µM 0.862003942140095 0.136233389305626 no 488 0.194342674261711 974 774970
SGTC_2947 9072639 7.68 µM 0.855760673144887 0.137765394150264 no 489 0.196065086124167 1054 16488146
SGTC_2249 haloperidol 116.36 µM 0.854828297063882 0.137995190258497 no 490 0.196323105164678 1047 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2186 6124449 200 µM 0.853173308613937 0.138403727079175 no 491 0.196781601390085 959 3834182 YLR033W RSC58
SGTC_1084 voriconazole 435 nM 0.852302021171937 0.138619136813144 no 492 0.197023242263982 1009 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_772 k072-0172 35.3 µM 0.851816532347492 0.138739264001916 no 493 0.197157964510709 906 5861980
SGTC_2160 5660466 132.927 µM 0.846423703801231 0.140078409834566 no 494 0.198658209866414 928 2859134
SGTC_1143 3454-2408 5.08 µM 0.844361875918486 0.140592715478018 no 495 0.199233609676897 947 X1143
SGTC_2738 aclarubicin 5.55 µM 0.844017685482906 0.140678695571417 no 496 0.199329761493805 895 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1973 st070275 50.2 µM 0.843055692592204 0.140919194308968 no 497 0.199598648554658 965 17118334
SGTC_3210 9128157 49.47 µM 0.842837337100681 0.140973822113286 no 498 0.199659711576909 868 17590849
SGTC_2829 7992743 58.44 µM 0.841083231459153 0.141413182409656 no 499 0.200150654202771 1005 16462845
SGTC_368 fentichlor 4.58 µM 0.840757661709656 0.141494831616026 no 500 0.200241855086735 908 7329 A pesticide.
SGTC_1141 3253-0389 52.6 µM 0.839989119148185 0.141687700076573 no 501 0.200457243653853 990 5402031
SGTC_1761 st044296 37 µM 0.836762401832589 0.14249939887846 no 502 0.201363067601118 1021 1826700
SGTC_2663 amphotericin b 100 µM 0.836475703831743 0.142571671195216 no 503 0.201443669736752 991 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2849 9019321 12.99 µM 0.835820724251436 0.142736874827132 no 504 0.201627882903787 916 16489627
SGTC_1974 st069448 26.9 µM 0.83285415372218 0.143486744495181 no 505 0.202463494356009 1001 6323587 YNR016C ACC1
SGTC_1334 1486-0610 236 µM 0.832654693708701 0.143537257892516 no 506 0.202519751626378 985 3742339
SGTC_2955 9076254 12.21 µM 0.831169488854882 0.14391376457416 no 507 0.202938944261978 954 16459619
SGTC_1075 aripiprazole 15.2 µM 0.830555028075529 0.144069728026312 no 508 0.203112524596833 1049 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1469 k284-2957 126 µM 0.829074041401284 0.144446102785585 no 509 0.203531255791437 1016 23884841
SGTC_1764 st044502 93.5 µM 0.827486175197628 0.144850375087545 no 510 0.203980777365542 994 8407
SGTC_676 falcarinol 140 µM 0.82703329128926 0.144965819280072 no 511 0.204109096185847 1050 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1446 4239-0190 62 µM 0.821273336347253 0.146439487001647 no 512 0.205745295945392 1012 1340085
SGTC_2335 9018011 154.17 µM 0.819666096493151 0.146852483044451 no 513 0.206203241254362 1046 6458208
SGTC_2934 9036370 36.88 µM 0.818448380676642 0.147165906799532 no 514 0.206550602804132 1048 6462800
SGTC_3278 9139605 49.47 µM 0.814058396215299 0.148299550386005 no 515 0.207805749041079 986 7958859
SGTC_1276 0871-0068 94.2 µM 0.813505782666072 0.148442666894848 no 516 0.207964066103937 997 3414906
SGTC_18 0111-0177 500 nM 0.813259347600275 0.148506518708545 no 517 0.208034689706413 1114 721752
SGTC_962 1254-0300 21.5 µM 0.812700143819603 0.148651477628375 no 518 0.208194999376169 1006 7340576
SGTC_1138 3761-0006 1.03 µM 0.811067206919472 0.149075314946636 no 519 0.208663538370038 1033 12061087
SGTC_2745 rifampicin 24.3 µM 0.810689158632041 0.149173554316138 no 520 0.208772100396608 918 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1090 efavirenz 20.7 µM 0.809304454738165 0.149533751649361 no 521 0.209170022245577 1020 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2320 7373003 200 µM 0.809121842758775 0.149581297038003 no 522 0.209222532689245 1050 5415828
SGTC_2978 9011784 42.97 µM 0.807199968413419 0.150082293595644 no 523 0.209775641971513 1115 2994934
SGTC_2764 methyldopa 94.69 µM 0.806060167385005 0.150379946184249 no 524 0.210104078763162 1023 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2935 9038016 29.96 µM 0.8060044924986 0.150394495434333 no 525 0.210120129368765 1045 6463195
SGTC_20 0481-0013 4.944 µM 0.803553576831057 0.151035910862998 no 526 0.210827421449043 1056 182045
SGTC_653 0203-0016 55.2 µM 0.800612150647489 0.151808094986451 no 527 0.211678107138048 1053 295302
SGTC_1751 st044839 27.194 µM 0.799436315463942 0.152117508234023 no 528 0.212018730047467 1058 5291326
SGTC_1309 pyrazolanthrone 13.4 µM 0.798760572097805 0.152295514992412 no 529 0.212214628351296 1077 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_276 colchicine 750 µM 0.797219596299775 0.152701961423499 no 530 0.212661753474644 1065 2833 A microtubule depolymerizer.
SGTC_1106 tegaserod maleate 11.7 µM 0.795196622131951 0.153236630656963 no 531 0.213249568194308 1039 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1628 st004252 77.7 µM 0.793795725405164 0.153607611796395 no 532 0.213657180781157 1041 692968
SGTC_3044 9093193 49.47 µM 0.791926937208161 0.154103423582117 no 533 0.214201639619514 1068 25236277
SGTC_2346 9031566 143.75 µM 0.790171827620557 0.154570038069848 no 534 0.214713713254526 1045 4771086
SGTC_1268 0828-0275 2.46 µM 0.78996296536284 0.154625628424826 no 535 0.214774698575859 1081 745337
SGTC_503 tyrphostin 8 294 µM 0.788706072457935 0.15496043945211 no 536 0.215141908966981 1048 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3271 9137798 49.47 µM 0.78703960432827 0.155405090790983 no 537 0.215629341258511 991 6498326
SGTC_1081 sertraline 6 µM 0.786065863223582 0.155665296225323 no 538 0.215914451042268 1068 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3238 9133470 49.47 µM 0.785985693644608 0.155686732127625 no 539 0.215937934290667 1064 3534688
SGTC_288 1315-0019 35.1 µM 0.785417362061893 0.155838749577027 no 540 0.216104452228273 1069 6811474
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.784776870178744 0.156010185729565 no 541 0.216292201829737 1013 1241132 A phosphatase inhibitor.
SGTC_979 1426-2828 121 µM 0.78357319269106 0.156332702153889 no 542 0.216645295340972 1098 747872
SGTC_1181 1222-0449 220 µM 0.782150423315571 0.156714488548814 no 543 0.217063088153007 1067 658318
SGTC_1055 3448-0672 86 µM 0.7806981826441 0.157104815618446 no 544 0.217490014878434 1024 748378
SGTC_840 0245-0196 390 µM 0.776143579582063 0.158333126104612 no 545 0.218832107395247 1115 3827528
SGTC_3181 9108277 49.47 µM 0.774053207981569 0.158898972893124 no 546 0.219449663401343 1059 17097298
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.773462186100441 0.159059197793986 no 547 0.219624449689082 1039 17037758
SGTC_2441 5730946 39.09 µM 0.77167276326691 0.159544952060708 no 548 0.220154133141757 1076 1774275
SGTC_1364 1653-0028 37.6 µM 0.76898160131427 0.1602773174669 no 549 0.220952116459539 1044 5718652
SGTC_2210 7115885 190.385 µM 0.76881952033128 0.160321495780981 no 550 0.221000229513647 1096 2927039
SGTC_2035 5154463 94.595 µM 0.768642256061809 0.160369821704632 no 551 0.221052856526695 1083 2769623
SGTC_2176 5809774 33.9695 µM 0.76852257556742 0.160402454476935 no 552 0.221088391865006 1098 2870539
SGTC_737 1950-0117 57.9 µM 0.764553542379097 0.161487131656104 no 553 0.222268721125432 1084 5393513
SGTC_268 camptothecin 39.6153 µM 0.763888837721239 0.161669251916273 no 554 0.222466744933049 1112 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_41 0478-0632 82.643 µM 0.762126225309784 0.162152832243849 no 555 0.222992336003794 1132 3750424
SGTC_404 fumagillin 50 µM 0.759915166645975 0.162760776189092 no 556 0.223652647603534 1088 12015870 A methionine aminopeptidase binder.
SGTC_2130 NSC 7 2.4545 µM 0.759550157638271 0.162861280001291 no 557 0.223761760886675 1102 21448
SGTC_704 1310-0270 142 µM 0.75933337718639 0.162920988753129 no 558 0.223826578064999 1127 5718033
SGTC_2113 5491891 107.031 µM 0.756792089793448 0.163622007463659 no 559 0.224587216310539 1145 789979
SGTC_356 1634-0012 32.5 µM 0.753190137509998 0.164618962507127 no 560 0.225667832520204 1118 735457
SGTC_854 0422-0053 192 µM 0.75314669341071 0.164631011019728 no 561 0.225680884047663 1128 3596728
SGTC_435 c-PAF 6.7 µM 0.752976633753782 0.164678179788801 no 562 0.225731977677581 1095 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_968 1309-0633 340 µM 0.751479953928966 0.16509368549483 no 563 0.226181930260946 1106 3761976
SGTC_2077 5212015 200 µM 0.749319199039321 0.165694746705526 no 564 0.226832419363357 1057 780900
SGTC_2412 st077135 33.4 µM 0.749171660812451 0.165735839229762 no 565 0.226876873784339 1096 13258915
SGTC_2461 5755302 26.15 µM 0.749163021118293 0.165738245771959 no 566 0.226879477144026 1101 2788904
SGTC_2741 miltefosine 3.04 µM 0.74806393519694 0.166044574721854 no 567 0.227210797088313 1004 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2382 9035899 200 µM 0.745950732772428 0.166634577767342 no 568 0.227848588455158 1153 6462679
SGTC_2296 7971656 126.45 µM 0.745392663110854 0.16679061556448 no 569 0.228017188972934 1132 666570
SGTC_2812 7970281 58.44 µM 0.742762683541625 0.167527233463286 no 570 0.228812685834849 1129 2233435
SGTC_1808 st050063 61.5 µM 0.7423946738221 0.167630474371023 no 571 0.228924122819028 1113 4011993
SGTC_1727 st034309 9.9045 µM 0.741089576812814 0.167996934645837 no 572 0.22931956453099 1158 870305
SGTC_2159 5658611 73.75 µM 0.740099941766067 0.168275159313952 no 573 0.229619677025222 1157 793844
SGTC_24 0417-1663 219 µM 0.739167591894436 0.168537549898755 no 574 0.229902618631711 1113 4329390
SGTC_869 0564-0080 44.1 µM 0.737647764073602 0.168965837548957 no 575 0.23036426114243 1093 6843321
SGTC_1560 lithocholic acid 53.1 µM 0.736581433730028 0.169266746509928 no 576 0.23068846448735 1083 9903 A bile acid which acts as a detergent.
SGTC_1832 st054113 55 µM 0.736051683533195 0.169416365141128 no 577 0.230849622607037 1123 1251267
SGTC_3346 9158254 43.5805 µM 0.73438011948765 0.169889025250797 no 578 0.231358549930678 1101 17639500
SGTC_802 4112-3352 742 µM 0.732710946702223 0.170361852012891 no 579 0.23186737299063 1162 704594
SGTC_2069 5228469 200 µM 0.732432979129919 0.170440673713168 no 580 0.231952167863996 1106 2835210
SGTC_2424 5537928 59.2 µM 0.732348972756726 0.170464499522763 no 581 0.231977797667229 1199 5382802
SGTC_3354 9151612 71.43 µM 0.728916347543303 0.171439881375771 no 582 0.233026417162464 1151 27261949
SGTC_230 MPP+ 141.667 µM 0.725905502804457 0.172298344628699 no 583 0.233948351426997 1135 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2032 5185112 25.99 µM 0.723909310175575 0.172869015769364 no 584 0.234560706913201 1091 5718189
SGTC_2953 9074162 66.49 µM 0.723658990654688 0.172940661959548 no 585 0.234637557868662 1083 16451992
SGTC_877 0771-0151 33.1 µM 0.721774633613403 0.173480607812399 no 586 0.23521652375083 1145 6166523
SGTC_925 2064-1272 59.6 µM 0.720419274195324 0.173869636748992 no 587 0.235633443173835 1104 6815817
SGTC_2246 7293507 91.5585 µM 0.719692944255606 0.174078343442148 no 588 0.235857035725558 1174 887656
SGTC_2654 protoveratrine a 100 µM 0.718931744606156 0.174297240574979 no 589 0.236091487990375 1154 5702278 A heart drug and vasodilator.
SGTC_2718 lomofungin 53.02 µM 0.718006059432055 0.17456367414273 no 590 0.236376775323845 1176 5351222 A RNA synthesis inhibitor.
SGTC_2902 5787006 60.46 µM 0.717252510435408 0.174780753807481 no 591 0.236609151986574 1136 591003
SGTC_1031 k035-0009 16 µM 0.713158060878695 0.175963261178892 no 592 0.237873977419728 1202 5180959
SGTC_3248 9135562 49.47 µM 0.713023273327087 0.176002274758502 no 593 0.237915677879888 1206 17650701
SGTC_565 1418-0001 44.5 µM 0.711684345906774 0.176390117949004 no 594 0.238330131715538 1189 2862145
SGTC_763 3453-1109 128 µM 0.711622748047281 0.176407973821199 no 595 0.238349208329838 1191 1560353
SGTC_3180 9109287 49.47 µM 0.711566794872039 0.176424194413986 no 596 0.238366537532472 1155 18891271
SGTC_3058 9093861 49.47 µM 0.711206995583851 0.176528521270888 no 597 0.238477987096715 1178 17217477
SGTC_2475 5812728 15.03 µM 0.710103340725543 0.176848778711399 no 598 0.238820027410704 1196 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1424 4048-1941 275 µM 0.709532952453593 0.17701443724628 no 599 0.238996904992895 1217 X1424
SGTC_1174 0739-0097 51.1 µM 0.708910493825995 0.177195330477949 no 600 0.239190011308815 1171 728447
SGTC_2358 9037157 4 µM 0.707839978485829 0.17750670681164 no 601 0.239522318276514 1179 2388925
SGTC_3343 9148379 18.9835 µM 0.706744065622242 0.1778258279409 no 602 0.239862770022329 1212 1955036
SGTC_1186 1319-0216 26 µM 0.705873355300727 0.178079629688352 no 603 0.240133449340866 1233 4565136
SGTC_277 nystatin 15.5 µM 0.705611943756555 0.178155872609784 no 604 0.240214747313936 1184 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1107 amlodipine 47 µM 0.705085506519741 0.178309474980436 no 605 0.240378512754748 1102 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2074 5212007 75.395 µM 0.704471163812353 0.17848883164399 no 606 0.240569700926564 1117 758611
SGTC_280 3448-3607 3.04 µM 0.704165443975123 0.178578128539484 no 607 0.240664874131953 1173 626179
SGTC_2196 6573537 42.6665 µM 0.704120700739716 0.178591199832108 no 608 0.240678804803604 1210 2903087
SGTC_1830 st055982 50.3 µM 0.703257546757408 0.178843479633238 no 609 0.240947631080889 1140 455313 An antimicrobial agent.
SGTC_3159 9100096 49.47 µM 0.703128794294529 0.178881130195101 no 610 0.240987744576132 1164 25236875
SGTC_2118 5526350 200 µM 0.702752286930379 0.178991259342212 no 611 0.241105068227706 1178 743594
SGTC_232 clozapine 119 µM 0.700678289942573 0.179598672095235 no 612 0.241751903810145 1144 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2657 nystatin 74.44 µM 0.70060515639252 0.179620114380252 no 613 0.241774729788231 1202 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2879 9041815 71.43 µM 0.699578722631659 0.179921227855516 no 614 0.242095217132393 1139 4942971
SGTC_893 0958-0369 48.9 µM 0.696858963428242 0.180720625168824 no 615 0.24294553067887 1205 6819948
SGTC_31 0508-1974 57.237 µM 0.695795551294384 0.181033790112524 no 616 0.243278437831207 1167 6810525
SGTC_501 nsc-95397 161 µM 0.693068400326723 0.18183846352026 no 617 0.244133313604076 1205 262093
SGTC_1540 guanosine 70.6 µM 0.692804112471324 0.181916563050398 no 618 0.244216245522236 1145 6802 Guanosine is a purine nucleoside
SGTC_1750 st081859 2.357 µM 0.692297804256829 0.182066240436724 no 619 0.2443751643651 1220 5291695
SGTC_1359 1582-0056 520 nM 0.691839414321848 0.18220181836776 no 620 0.244519090784208 1220 3661189
SGTC_3063 1327-0034 4 µM 0.69128276092145 0.182366544488432 no 621 0.244693931589514 1136 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_652 0437-0092 114 µM 0.690116764377002 0.182711890263854 no 622 0.245060380736804 1189 3091274
SGTC_838 0109-0203 71.4 µM 0.688069711563923 0.183319174873192 no 623 0.245704441461946 1217 759422
SGTC_1713 st033146 12.748 µM 0.687760902246077 0.183410896270025 no 624 0.245801680447989 1209 674619
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.687569069941324 0.183467887992496 no 625 0.245862095693189 1175 688662
SGTC_2639 lactacystin 53 µM 0.686961899367257 0.18364834588324 no 626 0.246053369185107 1223 3870 A proteasome inhibitor.
SGTC_3242 9133940 49.47 µM 0.68476327128026 0.184302727660479 no 627 0.246746657856133 1259 17248444
SGTC_2803 7707263 71.43 µM 0.682767290959211 0.184898049792244 no 628 0.247376950670555 1200 2199229
SGTC_757 1066-0008 322 µM 0.678915087674149 0.186050384147992 no 629 0.248595832663059 1218 6842497
SGTC_1145 3546-0597 10.2 µM 0.677817551439084 0.18637951041195 no 630 0.24894369059969 1196 875334
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.676284693402902 0.186839783043093 no 631 0.249429954544084 1062 4000243
SGTC_2536 dehydroabietamide 32.04 µM 0.67607337695869 0.18690329034504 no 632 0.249497029394592 1244 3983547
SGTC_1627 st003713 25.6 µM 0.673767768345666 0.187597066600411 no 633 0.250229484769521 1268 16195070 YER133W GLC7
SGTC_1449 4112-4002 201 µM 0.672595269735161 0.18795049044314 no 634 0.250602405945155 1204 2059539
SGTC_2622 2-methoxyxanthone 59.94 µM 0.672456572181107 0.18799232493465 no 635 0.250646539112844 1250 71034 A hepatoprotective.
SGTC_1290 0986-0249 10.2 µM 0.672339256872451 0.188027714517887 no 636 0.250683871724226 1189 53329
SGTC_1343 1487-0095 224 µM 0.671558722865062 0.188263276741029 no 637 0.25093233176743 1229 4560101 YGL055W OLE1
SGTC_1410 3909-8106 77.9 µM 0.671004830103007 0.188430549890549 no 638 0.251108726264222 1259 1039210
SGTC_880 0833-0487 87.2 µM 0.669065479494635 0.189016947149472 no 639 0.25172685471448 1218 76075
SGTC_2469 5655019 90.81 µM 0.665622444397618 0.190060775863992 no 640 0.252826228343104 1289 2788239
SGTC_2043 5101342 149 µM 0.66172471068696 0.191246722257559 no 641 0.2540738325631 1242 678451
SGTC_320 4092-0846 5.34 µM 0.658856304111349 0.192122370657831 no 642 0.254994023741252 1233 1359356
SGTC_2271 7849410 118.62 µM 0.657653514205805 0.192490279289863 no 643 0.255380399640766 1246 972430
SGTC_2583 asiatic acid 100 µM 0.653480281130953 0.193770121437939 no 644 0.256723348889643 1279 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_364 0083-0097 67.7 µM 0.653342201677835 0.193812555950979 no 645 0.256767845704389 1303 5207356
SGTC_685 1278-0033 54.9 µM 0.652827166264728 0.19397088635799 no 646 0.256933853926821 1322 3590572
SGTC_2863 9028737 58.44 µM 0.651407081381849 0.194407852036882 no 647 0.257391870318146 1252 6460917
SGTC_1695 st026914 34.495 µM 0.650391595289737 0.194720688254132 no 648 0.25771965244918 1250 3289191
SGTC_1015 4130-4525 82 µM 0.650265062999361 0.19475968993161 no 649 0.257760510158823 1242 1363237
SGTC_2164 5685496 200 µM 0.649477280599985 0.195002618895648 no 650 0.25801496339994 1253 759046
SGTC_1139 k015-0024 46.9 µM 0.648973304233096 0.195158126993432 no 651 0.258177815771814 1257 2766652
SGTC_1066 ketoconazole 628 nM 0.648967873170287 0.195159803224951 no 652 0.258179571028135 1298 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1319 1306-0155 43.7 µM 0.64764100720361 0.195569586444024 no 653 0.258608583986801 1300 3122360
SGTC_2526 patulin 37.61 µM 0.645030616764465 0.196377291028558 no 654 0.259453672518598 1318 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1283 0922-0125 16.4 µM 0.644559030373955 0.196523424189836 no 655 0.259606496007677 1266 3360884
SGTC_2211 7117706 200 µM 0.644119518430055 0.196659677564093 no 656 0.259748967197799 1234 822771
SGTC_1036 k216-0215 33.5 µM 0.643334689885293 0.196903125034193 no 657 0.260003475749924 1270 622330
SGTC_921 1561-0023 372 µM 0.643167931853438 0.196954875520023 no 658 0.260057569529132 1267 24050882
SGTC_281 1672-3440 14.9 µM 0.642462195563025 0.197173979774885 no 659 0.260286563916271 1273 6833000
SGTC_2805 7950783 58.44 µM 0.642266846099086 0.197234654398902 no 660 0.260349968455429 1278 1178958 YDL195W SEC31
SGTC_2966 9084041 48.03 µM 0.64082518678093 0.197682776171498 no 661 0.260818133458145 1201 17741380
SGTC_2898 9056270 58.44 µM 0.640560583588595 0.197765091548754 no 662 0.26090410781665 1218 19154699
SGTC_1369 1866-0067 208 µM 0.640097249032949 0.197909280120661 no 663 0.261054688685816 1310 3531355
SGTC_1790 st045711 43.5 µM 0.63736744958467 0.198760075459524 no 664 0.261942762798077 1317 585119
SGTC_1522 st012842 45.6 µM 0.637221908300932 0.19880549807817 no 665 0.261990154587547 1219 3491067 YOR116C RPO31
SGTC_1214 0358-0031 63.7 µM 0.635511535364277 0.199339764640496 no 666 0.262547422886266 1409 4301366
SGTC_2462 5162487 171.77 µM 0.633427530447563 0.199991909188961 no 667 0.263227245788749 1262 2259986
SGTC_2600 tangeritin 87.95 µM 0.633108844780439 0.200091747976777 no 668 0.263331283392988 1254 68077 A bioactive flavone.
SGTC_3352 9151559 45.5865 µM 0.631859304430586 0.200483496612129 no 669 0.263739408767635 1256 17159339
SGTC_52 0329-0193 875 nM 0.630619766760834 0.200872564032783 no 670 0.264144585559401 1360 3739292
SGTC_3106 9121286 49.47 µM 0.627321693969094 0.201909970857433 no 671 0.265224192896663 1321 15943471
SGTC_2121 5257820 149.641 µM 0.626657238318624 0.202119362506802 no 672 0.265441969916605 1329 791256
SGTC_27 0485-0001 32.618 µM 0.625566739211443 0.202463295829607 no 673 0.265799580304696 1246 2054479
SGTC_1966 st070145 16.1 µM 0.625092620216852 0.202612937646047 no 674 0.265955135588386 1234 3748532
SGTC_2329 6138490 200 µM 0.624755762914031 0.202719296975276 no 675 0.266065684244208 1334 720019
SGTC_1891 st059073 26.2 µM 0.624578004607766 0.202775435830498 no 676 0.266124029725004 1337 688754
SGTC_852 0418-0143 439 µM 0.624162753513032 0.202906614814026 no 677 0.266260352533091 1329 5369229
SGTC_710 3448-4187 58 µM 0.623542094146985 0.203102777317604 no 678 0.266464174711691 1335 3946412
SGTC_190 3970-0790 3.722 µM 0.622375372759668 0.203471831782417 no 679 0.266847535097326 1317 2832352
SGTC_155 k072-0202 43.6 µM 0.622229421716985 0.203518026795015 no 680 0.266895511178164 1258 5857737
SGTC_3137 9097352 49.47 µM 0.622130219921529 0.203549428758625 no 681 0.266928122636695 1391 44120435
SGTC_3236 9132701 49.47 µM 0.622077419670179 0.203566143662363 no 682 0.266945480937708 1279 24282524
SGTC_1426 4048-4480 71.7 µM 0.621702223952669 0.203684942434494 no 683 0.26706884450056 1328 14224343
SGTC_1825 st052143 62.6 µM 0.6208879007801 0.203942924956995 no 684 0.267336691247636 1346 674173
SGTC_1088 bifonazole 369 nM 0.620598213465353 0.204034746588958 no 685 0.267432007716782 1257 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_851 0394-0702 453 µM 0.62027843758095 0.204136133931349 no 686 0.267537244195437 1311 762646
SGTC_2120 5538279 151.968 µM 0.618572990950082 0.2046773651621 no 687 0.268098849665812 1354 2058197
SGTC_1693 xanthone 101.9 µM 0.617535070966353 0.205007171225592 no 688 0.268440928089653 1358 7020 An insecticide.
SGTC_167 3672-0051 66.205 µM 0.614539079411962 0.205960938053031 no 689 0.269429578628695 1265 3237971
SGTC_2927 9011802 47.9 µM 0.614424044398307 0.205997611568864 no 690 0.269467575515116 1291 43912568
SGTC_21 0849-0113 22.993 µM 0.611414079396623 0.206958573416113 no 691 0.270462742028431 1296 1560156
SGTC_1119 parthenolide 318.541 nM 0.610907622932228 0.207120525114708 no 692 0.270630368988261 1428 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3168 9103419 49.47 µM 0.607460894783741 0.208224689464794 no 693 0.271772543421464 1284 16649256
SGTC_478 N-arachidonylglycine 10 µM 0.607026898532411 0.208363966567044 no 694 0.271916530675699 1279 5283389
SGTC_595 3909-8003 73.7 µM 0.604748161788464 0.209096154849732 no 695 0.272673170985991 1368 699517
SGTC_271 rotenone 740 µM 0.604158056909855 0.209286010038159 no 696 0.27286928181594 1360 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_398 bronopol 33.3 µM 0.601154436447212 0.21025394002129 no 697 0.273868564406913 1322 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_883 0850-0245 24.6 µM 0.598024871193293 0.211265247453042 no 698 0.274911668974268 1418 6823229 YPR165W RHO1
SGTC_5 0352-0601 109.883 µM 0.597341749950714 0.211486373877776 no 699 0.275139617797216 1264 762456
SGTC_48 0382-0018 55 µM 0.596800985516638 0.211661515453223 no 700 0.275320129950558 1441 762596
SGTC_2331 7980721 200 µM 0.595412926844011 0.212111465238247 no 701 0.275783743378228 1351 2981221
SGTC_269 exalamide 29 µM 0.594284491159046 0.212477668050176 no 702 0.276160924892664 1395 3316 A derivative of salicylamide.
SGTC_728 3030-5151 22.5 µM 0.594277032181665 0.212480089884562 no 703 0.276163418910452 1378 3125388
SGTC_1289 0976-0073 69.1 µM 0.593002565543138 0.212894129593295 no 704 0.276589717649095 1386 3391136
SGTC_2239 6685329 187.64 µM 0.592522364223695 0.213050256050598 no 705 0.276750424711921 1363 805680
SGTC_935 2996-0153 430 µM 0.59138024919148 0.213421856839344 no 706 0.277132835491712 1364 23738523
SGTC_1111 tnp00062 510.699 nM 0.590932991546327 0.213567480343785 no 707 0.277282659780953 1447 676306
SGTC_178 4092-0806 87.505 µM 0.589980496717663 0.213877797896351 no 708 0.277601862548752 1355 2169044
SGTC_3178 9107506 49.47 µM 0.589288759216187 0.214103326627007 no 709 0.277833792062875 1374 8897194
SGTC_392 N-ethylmaleimide 8.33 µM 0.589287472288463 0.214103746335877 no 710 0.277834223639154 1307 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2370 9071495 200 µM 0.588977373619566 0.214204893526429 no 711 0.277938225988827 1314 21791103
SGTC_1130 3454-2858 15.9 µM 0.587526038018923 0.214678655856526 no 712 0.278425234154409 1362 715628 YIL048W NEO1
SGTC_3111 9122088 49.47 µM 0.585718860539663 0.2152694267138 no 713 0.279032228776951 1286 16876704
SGTC_1045 1348-1485 165 µM 0.585622208983326 0.215301048906316 no 714 0.279064710214935 1362 6810614
SGTC_3217 9129673 49.47 µM 0.585387545998978 0.215377836517491 no 715 0.279143580446243 1343 17248312
SGTC_427 1354-0053 47.3 µM 0.584916719035006 0.215531950815652 no 716 0.279301858069136 1435 6813657
SGTC_134 0269-0018 6.916 µM 0.584620694668723 0.215628880271819 no 717 0.279401394728646 1309 4378915
SGTC_937 3122-0005 46.7 µM 0.583309661394512 0.216058465370311 no 718 0.279842429897067 1357 759535
SGTC_1797 st048695 56.8 µM 0.58124206640026 0.216736958773333 no 719 0.280538659942312 1353 592262 YIL048W NEO1
SGTC_1834 st055981 52.8 µM 0.581066090712947 0.216794763068425 no 720 0.280597955671304 1432 471719 YDL150W RPC53
SGTC_977 1348-1378 135 µM 0.580819088479366 0.216875913118276 no 721 0.280681194314237 1339 X977
SGTC_702 1488-0190 94 µM 0.580639267875667 0.216935002376797 no 722 0.280741800561899 1380 949357
SGTC_443 clozapine 122 µM 0.580599295502502 0.216948138608965 no 723 0.280755273601692 1303 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1594 piperine 70.1 µM 0.580370680955687 0.217023277677238 no 724 0.280832336152348 1341 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2696 st077691 74.316 µM 0.579925502812597 0.217169638159341 no 725 0.280982428398687 1379 757133
SGTC_1816 st051957 91.6 µM 0.579348380285959 0.21735946262845 no 726 0.281177063505938 1383 674121
SGTC_1660 st012960 28.1 µM 0.578945512182859 0.217492028903822 no 727 0.281312969726123 1341 24207266
SGTC_1758 st042942 75.2445 µM 0.578221632773355 0.217730343194299 no 728 0.281557247695139 1333 669317
SGTC_1919 st067113 52.3 µM 0.577908279478527 0.217833551511363 no 729 0.281663022590652 1367 1268243
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.577674348492021 0.217910619112306 no 730 0.281742000343747 1340 140250 A respiratory chain inhibitor.
SGTC_2232 chlorophetanol 41.5365 µM 0.576934537830853 0.218154450155167 no 731 0.281991839049265 1438 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_130 0136-0219 337.655 µM 0.576239160022656 0.218383780055008 no 732 0.282226769745955 1352 234244
SGTC_756 0508-1999 28.3 µM 0.575731061739808 0.218551434466912 no 733 0.282398488319192 1326 6753853
SGTC_3311 9131146 2.8755 µM 0.575393911100038 0.218662723109463 no 734 0.282512460593217 1368 4900406 YPR165W RHO1
SGTC_694 1315-0438 43.2 µM 0.575383286849177 0.218666230553998 no 735 0.282516052433382 1401 6793154
SGTC_2022 5136654 200 µM 0.574712693680536 0.218887682824718 no 736 0.282742810577651 1388 1713771
SGTC_1969 st069479 40.1 µM 0.572958815136358 0.219467481748547 no 737 0.283336290016641 1429 3895485
SGTC_2127 5253358 187.912 µM 0.570216830510843 0.220375695370916 no 738 0.284265321092707 1337 20612
SGTC_2667 digitoxin 100 µM 0.56886511303519 0.220824209506362 no 739 0.284723841235721 1367 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2175 5807670 165.306 µM 0.56868631713793 0.220883574989209 no 740 0.284784517553824 1344 241186
SGTC_1510 1123-0200 71.5 µM 0.568280510928468 0.221018348452629 no 741 0.284922255163377 1497 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1144 3486-0183 12.5 µM 0.567820010483923 0.221171343565625 no 742 0.285078595415041 1378 6744069
SGTC_2357 9067248 200 µM 0.565227232615932 0.222033889470975 no 743 0.285959607977846 1394 9150235
SGTC_1924 st058459 75.1 µM 0.56515963428188 0.222056403235154 no 744 0.285982594843553 1349 688683
SGTC_2840 9008771 71.43 µM 0.565108781361813 0.222073340763677 no 745 0.285999887997131 1395 2992978
SGTC_118 0083-0097 135.343 µM 0.565003049759541 0.222108559037697 no 746 0.286035844904418 1438 5207356
SGTC_127 0180-0333 59.125 µM 0.564681151021418 0.222215800323613 no 747 0.28614532855002 1366 771601
SGTC_1430 4049-0248 69.1 µM 0.56429270764133 0.222345250438838 no 748 0.286277471743698 1460 22774488
SGTC_3038 9091290 49.47 µM 0.561008127956616 0.22344156644852 no 749 0.287395998146428 1431 25236843
SGTC_426 0988-0037 14.6 µM 0.560503575539904 0.223610246334455 no 750 0.287568000752731 1406 5383008
SGTC_2606 farnesol 9.78 µM 0.560261423528605 0.223691227308028 no 751 0.28765056798244 1455 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2395 5646831 180.19 µM 0.560192765806688 0.223714190998355 no 752 0.287673980431128 1449 6808628
SGTC_2940 9060638 45.86 µM 0.559396587005832 0.223980583799793 no 753 0.287945545070545 1437 4027022
SGTC_1473 k844-0725 134 µM 0.559233213820167 0.224035268974809 no 754 0.288001284174901 1431 54682906
SGTC_3259 9138485 49.47 µM 0.559012720121478 0.224109085868199 no 755 0.288076519535142 1494 17646153
SGTC_667 1498-1044 59 µM 0.557204143137326 0.224715082494009 no 756 0.288693979653446 1441 6739982
SGTC_1059 3448-6867 171 µM 0.555354554635369 0.225335780805512 no 757 0.289326085256306 1390 3934407
SGTC_2585 alliin 100 µM 0.555166984506353 0.225398781121373 no 758 0.28939022453841 1514 87310 A garlic compound which reacts with lipids.
SGTC_995 3931-2021 34.6 µM 0.555102268151496 0.225420520109343 no 759 0.289412355734245 1433 730143
SGTC_2238 6671620 73.2395 µM 0.554432947628016 0.22564542238763 no 760 0.289641291383908 1354 729941
SGTC_93 0109-0045 59.227 µM 0.553886426267224 0.225829156325024 no 761 0.289828287598203 1432 88733
SGTC_2827 7993847 71.43 µM 0.553871382879464 0.225834214928117 no 762 0.289833435602321 1408 2985692
SGTC_279 1273-0055 2.93 µM 0.553853358551031 0.225840276009207 no 763 0.289839603771898 1446 2847562
SGTC_1637 st007924 17.4 µM 0.550763076168897 0.226880811264742 no 764 0.290898049438083 1384 683336
SGTC_133 0724-0033 378.92 µM 0.548104611133887 0.227778108122672 no 765 0.291810037288112 1309 280309
SGTC_2491 paeonol 100 µM 0.546809248337819 0.228216047341378 no 766 0.292254894322352 1373 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2612 dictamnine 15.46 µM 0.544962858977563 0.228841096317124 no 767 0.292889531136572 1424 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2373 9071805 200 µM 0.540453755460487 0.230371571971932 no 768 0.294442072337383 1494 10149009
SGTC_497 capsazepine 133 µM 0.540080887655373 0.230498386089492 no 769 0.294570625305194 1361 2733484 A calcium channel blocker.
SGTC_2512 diallyl trisulfide 49.23 µM 0.539955597636309 0.230541006578583 no 770 0.294613827133556 1383 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1397 3532-0190 20.1 µM 0.53930903969689 0.230761019198629 no 771 0.29483681620184 1426 5322280
SGTC_2497 7-hydroxyflavone 100 µM 0.538699047860865 0.230968696470734 no 772 0.295047265413598 1458 5281894
SGTC_78 0336-0123 156.75 µM 0.536626568166497 0.231675069944586 no 773 0.295762794164625 1385 6765896
SGTC_2156 5649887 115 µM 0.536133486477736 0.231843306514832 no 774 0.295933149174048 1508 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_740 k014-0057 261 µM 0.535884078895334 0.231928428822864 no 775 0.296019334264037 1516 4012779
SGTC_493 zm226600 134 µM 0.534330267407524 0.232459133364069 no 776 0.29655652744316 1467 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2916 7875993 68.79 µM 0.534282690794787 0.232475393812175 no 777 0.29657298296461 1532 1299250
SGTC_3186 9110464 49.47 µM 0.53369241811305 0.232677186251189 no 778 0.296777177818651 1473 17018021
SGTC_287 k060-0039 29.6 µM 0.529849246827205 0.233993402354184 no 779 0.298108228741447 1521 5861974
SGTC_2558 carylophyllene oxide 100 µM 0.527911453160669 0.234658622238227 no 780 0.298780397515841 1486 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2195 6536160 144.242 µM 0.527767954126714 0.234707925183303 no 781 0.298830200872919 1345 3834386
SGTC_1939 st074455 53.6 µM 0.527685057414128 0.234736409183939 no 782 0.298858973061327 1543 1644229
SGTC_1203 3992-3522 103 µM 0.527476500844593 0.234808079409504 no 783 0.298931365441483 1668 5322312
SGTC_1416 3966-0321 25.3 µM 0.527441372474939 0.23482015242356 no 784 0.298943559685739 1430 582530 YLR208W SEC13
SGTC_285 1486-1325 46 µM 0.525883914770354 0.235355768449677 no 785 0.299484432803199 1484 22310230
SGTC_3231 9132313 49.47 µM 0.525468251448001 0.235498830676223 no 786 0.29962885911156 1478 4905967
SGTC_1692 fluoroquinolonic acid 71 µM 0.525296552098673 0.235557939838853 no 787 0.299688526947287 1455 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_311 1315-0136 58 µM 0.524336537881684 0.235888584799384 no 788 0.300022243947727 1508 6759207
SGTC_2284 7945075 39.21 µM 0.523461178890737 0.236190295932389 no 789 0.300326679835046 1536 1245402
SGTC_1846 st056244 14.8 µM 0.522580122162688 0.236494185416038 no 790 0.300633238198775 1481 5393182
SGTC_594 1487-1584 10.8 µM 0.521645431660814 0.236816809070486 no 791 0.300958612437902 1396 5013332
SGTC_2345 9052315 157.45 µM 0.521047984685231 0.237023154346882 no 792 0.301166672291706 1471 6469265
SGTC_1508 1080-0625 72.9 µM 0.520963698991801 0.2370522727555 no 793 0.301196029850806 1426 767111
SGTC_2496 diffractaic acid 79.83 µM 0.52093827123939 0.237061057736519 no 794 0.301204886847154 1570 94870 An apoptosis inducer which activates caspases.
SGTC_1875 nocodazole 6 µM 0.519382718819975 0.23759882239786 no 795 0.301746939931437 1463 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1954 st077032 68.9 µM 0.517992100542474 0.238080134409673 no 796 0.302231890431791 1372 698907
SGTC_1992 st073643 23.3 µM 0.516064617922287 0.238748145214162 no 797 0.302904639416125 1463 3161292
SGTC_2588 indole-3-carbinol 100 µM 0.515934199661055 0.238793381493335 no 798 0.302950183487151 1553 3712 Induces cell cycle arrest.
SGTC_2434 5670830 169.91 µM 0.515789652656819 0.238843523880939 no 799 0.303000665114046 1456 1549830
SGTC_1089 terbinafine 2.25 µM 0.514957850389249 0.239132182407621 no 800 0.303291237042283 1501 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.514723468020524 0.239213554028302 no 801 0.303373135884077 1449 15053
SGTC_1120 ficusin 1.78878 µM 0.51369229529697 0.239571730716816 no 802 0.303733569776172 1578 6199 A DNA cross-linker.
SGTC_1765 st044815 90.4 µM 0.512361904785172 0.240034272561928 no 803 0.304198873706546 1391 645695
SGTC_1859 st055998 20 µM 0.510939380276759 0.24052938514671 no 804 0.304696752474485 1597 676301
SGTC_1248 0469-0687 58.6 µM 0.510917156372005 0.240537124631717 no 805 0.30470453363987 1529 4017482
SGTC_396 dithiazanine 1.25 µM 0.510582612196226 0.240653646176598 no 806 0.304821676905368 1413 10578 An antihelmenthic.
SGTC_1304 1165-0502 251 µM 0.509985084455131 0.240861841172007 no 807 0.305030955711624 1493 767425
SGTC_712 r015-0009 80.6 µM 0.509246994184232 0.24111914721015 no 808 0.305289553349401 1518 6813872 YLR060W FRS1
SGTC_771 0250-0039 27.3 µM 0.50920001084836 0.241135531153037 no 809 0.305306017744259 1474 3005115
SGTC_2276 7947513 42.08 µM 0.507831029505015 0.241613185448832 no 810 0.305785923426384 1317 2105100
SGTC_146 3448-8650 53.125 µM 0.506755381932168 0.241988852105144 no 811 0.306163233145108 1508 2891488 YIL048W NEO1
SGTC_1579 chlormadinone acetate 49.4 µM 0.504539292307544 0.242763812380093 no 812 0.306941228995979 1557 45114258 A steroidal progestin.
SGTC_3100 9120536 49.47 µM 0.504355639103425 0.242828095605153 no 813 0.307005742660984 1446 16421196
SGTC_1189 1431-2119 7.28 µM 0.503591661681059 0.243095605688921 no 814 0.307274176631909 1483 3107275
SGTC_2292 7671323 168.05 µM 0.502580526966385 0.24344990389759 no 815 0.30762961152295 1462 937504
SGTC_3187 9109394 49.47 µM 0.501551589083842 0.243810726467767 no 816 0.30799149006549 1389 17098090
SGTC_53 0973-0023 39.979 µM 0.500174244852977 0.244294177797108 no 817 0.308476195827407 1486 674768
SGTC_2194 5927483 104.545 µM 0.49814170721111 0.24500854654234 no 818 0.309192082843865 1501 760979
SGTC_775 4577-0580 57.3 µM 0.497757558040024 0.245143688240928 no 819 0.309327466884788 1546 2006902
SGTC_3272 9137413 49.47 µM 0.497219257124274 0.245333127152426 no 820 0.309517221516708 1405 17614870
SGTC_1273 0849-0096 14.1 µM 0.496440318999126 0.245607390386546 no 821 0.309791892276354 1469 5286025
SGTC_3234 9132280 49.47 µM 0.495886518801828 0.245802482925959 no 822 0.309987239059656 1473 17612295
SGTC_2283 7944793 200 µM 0.494367930155616 0.246337877342885 no 823 0.310523179250351 1420 2970533
SGTC_2369 9071472 200 µM 0.49417944285515 0.246404374106862 no 824 0.310589728273094 1541 17296037
SGTC_2012 4023501 200 µM 0.493469311631985 0.246654988914884 no 825 0.310840509252814 1441 3477460
SGTC_1361 1608-0041 5.61 µM 0.493228925560653 0.246739855291735 no 826 0.310925420881232 1459 X1361
SGTC_2341 7987486 176.74 µM 0.492704008458998 0.24692522740239 no 827 0.311110872463848 1611 1258686
SGTC_1007 4101-0031 70 µM 0.491432633441451 0.247374516461429 no 828 0.311560244028741 1585 1146276
SGTC_2095 5432005 200 µM 0.490036700851364 0.247868325533098 no 829 0.312053964318932 1488 783734
SGTC_671 0560-0003 407 µM 0.488294020335228 0.248485533855072 no 830 0.31267079818626 1531 3238678
SGTC_691 1548-0686 185 µM 0.486788166003082 0.249019523878513 no 831 0.313204228752523 1459 46495133
SGTC_111 0083-0039 52.457 µM 0.486604304284345 0.249084764763788 no 832 0.313269386342677 1458 759313
SGTC_1229 0139-0193 12.2 µM 0.486228003013272 0.249218318608737 no 833 0.313402759540902 1590 3090752
SGTC_1868 st057644 42.7 µM 0.48607321636876 0.24927326530122 no 834 0.313457627960064 1477 688665
SGTC_1004 4084-0029 199 µM 0.484125200923347 0.249965328776003 no 835 0.314148508644364 1591 716894 YLR208W SEC13
SGTC_2363 9053361 176 µM 0.483931971132646 0.250034032277491 no 836 0.314217074846674 1613 6469797 YMR079W SEC14
SGTC_1703 st026983 48.3 µM 0.483741730386 0.250101682800922 no 837 0.314284586672115 1584 1104023
SGTC_777 1315-0167 517 µM 0.483534211723115 0.250175488505622 no 838 0.314358237096062 1459 4221767
SGTC_2705 st078069 42.8 µM 0.480593631381194 0.251222570282907 no 839 0.315402671329171 1482 1530061
SGTC_3118 9124250 49.47 µM 0.479071758998132 0.251765387251766 no 840 0.315943789871306 1478 1504786
SGTC_1646 st011709 75.6 µM 0.477695032585493 0.252256966974909 no 841 0.31643364018617 1566 5757843
SGTC_515 4092-1064 102 µM 0.476152668431375 0.252808290521663 no 842 0.316982808454306 1644 717353
SGTC_1421 4029-0249 71.4 µM 0.47609013654825 0.252830656138666 no 843 0.317005081833971 1617 2894095
SGTC_2394 5221648 200 µM 0.47565117028859 0.252987689382528 no 844 0.317161456928619 1666 788586
SGTC_2352 9027995 87.8 µM 0.474899789893839 0.253256602909345 no 845 0.317429200606966 1550 2997347
SGTC_616 4092-0450 108 µM 0.47465772694864 0.253343267457839 no 846 0.31751547663862 1554 787165
SGTC_3149 9097855 49.47 µM 0.474510912925922 0.253395838119593 no 847 0.317567808896267 1641 25236625 YMR079W SEC14
SGTC_2490 carminic acid 95.39 µM 0.474417354839767 0.253429342069043 no 848 0.317601159832504 1506 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2575 plumbagin 510 nM 0.474129781029077 0.253532339279897 no 849 0.317703681412773 1451 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_351 caspofungin 25 nM 0.471409791626236 0.254507615254589 no 850 0.318674062487865 1609 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3117 9124945 49.47 µM 0.471019905625023 0.254647573182631 no 851 0.318813260036435 1404 17592065
SGTC_3286 9117135 37.221 µM 0.470505039327148 0.2548324572066 no 852 0.318997117362799 1457 3438150
SGTC_361 000s-0510 1.45 µM 0.470390106164026 0.25487373830012 no 853 0.319038165759428 1531 660
SGTC_3162 9099653 49.47 µM 0.469163042537988 0.255314686668879 no 854 0.319476549962273 1529 25237511
SGTC_528 3492-0019 172 µM 0.468239730523205 0.255646743868571 no 855 0.319806581482512 1542 2869262
SGTC_1113 artemisinin 1.17947 µM 0.467901878686653 0.255768304240015 no 856 0.319927379970649 1615 2240 An anti-malaria and mitochondrial poison.
SGTC_1205 4161-2785 76 µM 0.467580095282032 0.255884111179344 no 857 0.320042450968528 1455 3498106
SGTC_2327 6189656 200 µM 0.4667852062606 0.256170301801864 no 858 0.320326780572008 1635 5349088
SGTC_1950 st077106 7.18 µM 0.466663581460405 0.256214106126418 no 859 0.320370294737741 1492 13831864
SGTC_1897 st060201 15 µM 0.466202372445225 0.256380250401354 no 860 0.320535325671605 1486 611878
SGTC_695 3505-6186 243 µM 0.465470538685741 0.256643998741582 no 861 0.320797265032837 1578 1819379
SGTC_2842 9000675 19.48 µM 0.465095450232182 0.256779233034896 no 862 0.320931552019868 1457 2989072
SGTC_106 0092-0003 11.579 µM 0.464071792666525 0.257148490928887 no 863 0.321298155124113 1621 1072148
SGTC_2430 5571206 200 µM 0.462370600949859 0.257762761841059 no 864 0.321907789094032 1613 1731771
SGTC_1009 4106-0057 9.87 µM 0.462068775538986 0.257871825275771 no 865 0.32201600049002 1534 2928005
SGTC_1370 2001-0092 44.6 µM 0.46172526029886 0.257995982295825 no 866 0.322139177017987 1702 790957
SGTC_1715 st032160 10.2275 µM 0.461433184999253 0.258101571716832 no 867 0.322243923756143 1597 5289825
SGTC_1057 3448-5381 134 µM 0.460385381618532 0.258480552015546 no 868 0.322619812791278 1642 5497911
SGTC_60 0986-0278 202 µM 0.459760753342211 0.258706611044264 no 869 0.322843978277121 1367 3110598
SGTC_569 4130-2812 160 µM 0.45820415711916 0.259270403270465 no 870 0.323402886762315 1557 743552
SGTC_2379 9035213 200 µM 0.4572318548778 0.259622888715251 no 871 0.323752202167262 1671 646551
SGTC_3304 9125678 46.087 µM 0.456209246737669 0.259993878134247 no 872 0.324119758371768 1536 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1392 3455-1037 33.9 µM 0.455975780961897 0.260078614907882 no 873 0.32420369707174 1599 981132
SGTC_3071 9117417 49.47 µM 0.455529960218671 0.260240465799631 no 874 0.324364009256815 1615 45595590 YGL055W OLE1
SGTC_2220 6782180 200 µM 0.455351375332362 0.260305313865495 no 875 0.324428235532563 1556 833803
SGTC_1927 st060202 13.8 µM 0.454270337882795 0.260698039792882 no 876 0.324817131328521 1624 688887
SGTC_2324 6149169 200 µM 0.453724323394712 0.260896515127797 no 877 0.325013628920989 1592 2888231
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.451284080001771 0.261784488280304 no 878 0.325892408680009 1676 6728940
SGTC_2269 7935389 174.42 µM 0.451023471051726 0.261879412067441 no 879 0.325986316400957 1488 97605
SGTC_88 0180-0332 8.668 µM 0.449939222984112 0.262274526250373 no 880 0.326377132340474 1584 3101745
SGTC_1815 st051655 58.2 µM 0.449741821371073 0.262346494825744 no 881 0.326448306051011 1608 5984156
SGTC_1492 4158-0558 28.5 µM 0.448399807074543 0.262836033639853 no 882 0.326932340499825 1653 3967268
SGTC_2843 9000894 45.46 µM 0.448259603045431 0.262887204082223 no 883 0.32698292576928 1494 2242070
SGTC_1502 4534-4282 27.7 µM 0.447559760463318 0.263142702665977 no 884 0.327235474781085 1564 3278949
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.446394460103759 0.263568411932047 no 885 0.327656166920168 1520 6708561
SGTC_788 1182-0090 188 µM 0.443537833151057 0.264613483770148 no 886 0.328688380187314 1715 5715185
SGTC_3225 9130819 49.47 µM 0.441908308478396 0.265210573765569 no 887 0.329277779060519 1606 4547121
SGTC_3096 9117468 49.47 µM 0.441227563616956 0.26546021455532 no 888 0.329524130199726 1520 41316311
SGTC_3105 9121040 49.47 µM 0.44000782960677 0.265907809893822 no 889 0.329965718291751 1507 41448907
SGTC_1479 0549-0158 134 µM 0.439578699664803 0.266065374918668 no 890 0.330121135345188 1570 5440202
SGTC_1074 carmofur 3.8 µM 0.438820743030222 0.266343791772347 no 891 0.330395714457219 1580 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2707 st078556 66.6 µM 0.437270753999233 0.266913601014982 no 892 0.330957501291839 1684 17250899
SGTC_2799 7812892 81.82 µM 0.436610732614906 0.267156425852775 no 893 0.331196838885377 1673 20205235
SGTC_32 0928-0142 34.1 µM 0.435874389804899 0.267427461224447 no 894 0.33146393363078 1594 2244242
SGTC_2423 st077119 87.2 µM 0.435406270921106 0.267599839973135 no 895 0.331633779691143 1527 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3277 9138724 49.47 µM 0.433362821157702 0.268352969355021 no 896 0.332375602993495 1570 15943418
SGTC_761 k216-0224 480 µM 0.43283598373142 0.268547312116755 no 897 0.332566964802307 1740 1340404
SGTC_2229 7354935 190 µM 0.432249336173752 0.268763801193855 no 898 0.33278010264506 1599 318112
SGTC_1640 st009078 66.4 µM 0.43175947066837 0.26894464217335 no 899 0.332958119534626 1652 690618
SGTC_3150 9097574 49.47 µM 0.431494552534411 0.269042466002479 no 900 0.333054406347903 1704 17217476
SGTC_745 0469-0705 296 µM 0.431033207296369 0.269212865239756 no 901 0.333222112582412 1699 3486736
SGTC_1913 st060213 96.1 µM 0.430264507477884 0.26949690700638 no 902 0.333501621100356 1702 688959
SGTC_650 1328-0195 38 µM 0.430018580050384 0.26958781119193 no 903 0.333591062805433 1632 2780821
SGTC_1404 3909-7820 48.3 µM 0.429782271363927 0.26967517439448 no 904 0.333677015168134 1670 23741373
SGTC_323 4013-0906 34.3 µM 0.429346123899889 0.269836455125401 no 905 0.333835677646256 1676 2910086
SGTC_1802 st050112 57.9 µM 0.428422389039535 0.270178197668358 no 906 0.3341718135884 1584 4662563
SGTC_2312 7706453 155.7 µM 0.423668391086296 0.271940390905679 no 907 0.3359038352162 1588 976098
SGTC_1878 temozolomide 1 mM 0.422301906412922 0.272447969824448 no 908 0.336402333414032 1714 5394 DNA alkylating agent.
SGTC_2131 toluylene red 5.2905 µM 0.420954679731626 0.272948855561173 no 909 0.336894087931699 1528 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2594 a-mangostin 100 µM 0.420576394601517 0.273089580341679 no 910 0.337032216909026 1714 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3161 9100388 49.47 µM 0.420353402241705 0.273172551941498 no 911 0.337113651783095 1660 25236368
SGTC_3232 9132874 49.47 µM 0.419523206383262 0.273481563234672 no 912 0.337416899191102 1546 3784940
SGTC_367 0335-0881 7.1 µM 0.418004238034594 0.274047393477801 no 913 0.337972009320509 1666 23828853
SGTC_2166 5933061 31.504 µM 0.414028297540268 0.275531202642484 no 914 0.339426691548922 1739 2877375
SGTC_1148 3909-7663 27.7 µM 0.413662047493564 0.275668084567597 no 915 0.339560812744609 1679 4084526
SGTC_2720 fluspirilene 36.88 µM 0.413102663784434 0.275877212574104 no 916 0.339765698929296 1664 3396 An atypical antipsychotic.
SGTC_2771 fluoxetine 41.05 µM 0.412918023954535 0.275946258074174 no 917 0.339833337592173 1661 3386 A selective serotonin reuptake inhibitor.
SGTC_1493 4348-0038 111 µM 0.412661185379544 0.276042316187016 no 918 0.339927433222622 1659 800424
SGTC_2190 6049624 200 µM 0.412111527319848 0.276247944492988 no 919 0.340128839989343 1650 2265554
SGTC_2972 9093619 59.92 µM 0.411799902555533 0.276364557389259 no 920 0.340243046407131 1546 25236256
SGTC_609 0986-0026 86.3 µM 0.411661468489886 0.276416368453809 no 921 0.340293785391591 1664 2848610
SGTC_2092 5303694 80.6725 µM 0.410744816086282 0.276759559779186 no 922 0.340629830622854 1591 1963699
SGTC_3091 9116372 49.47 µM 0.410598795570063 0.276814248597944 no 923 0.340683373508513 1616 17169793
SGTC_379 3970-0972 5.9 µM 0.409153153709129 0.277355967849993 no 924 0.341213635354402 1642 2898042 YBL034C STU1
SGTC_2056 5235370 200 µM 0.408684172941021 0.277531818319082 no 925 0.341385725077031 1579 5511916
SGTC_477 mead ethanolamide 10 µM 0.408031881185807 0.277776494195578 no 926 0.341625134523685 1583 16061185
SGTC_3119 9125183 49.47 µM 0.407083439338748 0.2781324443475 no 927 0.341973353070026 1624 22695334
SGTC_354 2783-3500 4.88 µM 0.404048959501677 0.279272776669358 no 928 0.343088358413088 1555 6740761
SGTC_2857 9024691 58.44 µM 0.402879421568799 0.279712885082347 no 929 0.343518465304804 1615 16478292
SGTC_1456 k015-0012 13 µM 0.399506038808914 0.280984203692946 no 930 0.344760187512017 1811 2989616
SGTC_1365 1672-3266 55.4 µM 0.398769866059407 0.281262014060615 no 931 0.345031391348005 1716 6415873
SGTC_1558 st069300 45.6 µM 0.397607211513407 0.281701036279298 no 932 0.345459871935927 1720 24208000
SGTC_358 0075-0058 9.45 µM 0.396429030206022 0.282146258203925 no 933 0.345894276809432 1872 1069125
SGTC_699 0375-0592 111 µM 0.396052843263157 0.282288486479103 no 934 0.346033022713249 1703 762578
SGTC_916 4466-0038 42 nM 0.39590449039095 0.282344585025625 no 935 0.34608774415503 1703 5722064 YGL116W CDC20
SGTC_619 1652-1634 108 µM 0.394489739526983 0.282879831926942 no 936 0.346609750500194 1618 5400454
SGTC_209 4077-0173 175.592 µM 0.393246039057918 0.283350766934917 no 937 0.347068884414151 1648 15993494
SGTC_2084 5306078 60.6385 µM 0.392155971704531 0.283763836686106 no 938 0.347471486683739 1685 679340
SGTC_297 0986-0032 24 µM 0.388925677229991 0.284989613786907 no 939 0.348665563480987 1625 2847425
SGTC_1428 4049-0204 61.7 µM 0.388835613947407 0.285023825617436 no 940 0.348698876888745 1733 X1428
SGTC_2257 7960413 200 µM 0.388500416065082 0.285151172548321 no 941 0.348822873111169 1722 2974689 YIL048W NEO1
SGTC_430 0958-0115 16.4 µM 0.38808639892182 0.285308501575615 no 942 0.348976048402015 1639 6833180
SGTC_2990 9074105 71.4286 µM 0.387822687180996 0.285408735190724 no 943 0.349073627539606 1652 6502001
SGTC_1545 lovastatin 49.4 µM 0.387047791857798 0.285703360440318 no 944 0.34936041356068 1672 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1793 st048256 72.231 µM 0.386397966246911 0.28595054405448 no 945 0.349600978048732 1633 672022
SGTC_2181 6316240 54.2555 µM 0.385125154327488 0.286434996366948 no 946 0.350072346121817 1581 12779990
SGTC_598 3937-0236 20.2 µM 0.382923924508246 0.287273737270504 no 947 0.350888085866005 1706 1379313
SGTC_1496 4469-0713 57.4 µM 0.382460824536511 0.287450341445408 no 948 0.351059790831119 1745 746691
SGTC_2890 9046729 58.44 µM 0.382373416067135 0.287483680613518 no 949 0.351092202944449 1588 903329
SGTC_2112 5488546 200 µM 0.381159002448775 0.287947068963785 no 950 0.351542634130709 1626 600757
SGTC_1895 st058434 18.3 µM 0.381011388309106 0.288003418672813 no 951 0.351597399070684 1771 5393175
SGTC_561 1550-0330 72.9 µM 0.37762742767513 0.289296625243034 no 952 0.352853693250682 1630 6812934
SGTC_1398 3558-0053 112 µM 0.376751593108375 0.289631776179468 no 953 0.353179108708717 1643 4532369
SGTC_141 0443-0274 32.331 µM 0.376710395715717 0.289647545452992 no 954 0.353194418205108 1766 1627241
SGTC_321 4534-3890 65.3 µM 0.376434943395005 0.289752991678369 no 955 0.353296786037392 1778 699746
SGTC_1180 1193-0155 285 µM 0.375885509804284 0.289963374774593 no 956 0.353501006704449 1628 2921347
SGTC_1641 st009299 47.1 µM 0.375325523374458 0.290177872320916 no 957 0.35370919319236 1719 4046054
SGTC_1475 4092-1048 11.7 µM 0.372386075650293 0.291305017689505 no 958 0.354802709847947 1649 2881759
SGTC_547 1120-0019 610 nM 0.372048401826163 0.291434631082781 no 959 0.354928406193007 1665 3676939
SGTC_820 1582-0060 59.9 µM 0.371409173973568 0.291680067216828 no 960 0.355166396816045 1628 3848840
SGTC_449 xestospongin c 11.1929 µM 0.370296212161816 0.292107626659646 no 961 0.355580897905071 1729 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.369906286717405 0.292257490800021 no 962 0.355726158530621 1590 641818 YHR062C RPP1
SGTC_3136 9095672 49.47 µM 0.368858264641161 0.29266046527362 no 963 0.356116686551946 1801 17217380
SGTC_2894 9048625 32.47 µM 0.368724273770506 0.29271200464309 no 964 0.356166626918974 1791 4092861
SGTC_2555 cholic acid 100 µM 0.368631807704657 0.292747574022284 no 965 0.356201091819813 1708 6708657 Influences liver metabolism.
SGTC_2862 9027634 71.43 µM 0.367323030762181 0.293251242845985 no 966 0.356689038463392 1609 5012562
SGTC_1356 1502-0781 85.8 µM 0.366018266948022 0.293753766740706 no 967 0.357175722463028 1684 567702
SGTC_2545 solidagenone 89.61 µM 0.365930076603818 0.293787747226038 no 968 0.357208626336981 1655 6708572 An anti ulcer agent
SGTC_742 0kpi-0133 140 µM 0.365781233865631 0.293845101716201 no 969 0.357264162066344 1804 2728852
SGTC_3052 9092717 49.47 µM 0.365517432540497 0.293946766630577 no 970 0.35736259820608 1666 25237534
SGTC_1634 st006576 41 µM 0.36504009073416 0.294130768045782 no 971 0.357540740027235 1819 3915356
SGTC_2785 7756463 72.73 µM 0.363946160414508 0.294552647074003 no 972 0.357949106950517 1617 2201551
SGTC_59 0330-0160 1.33 µM 0.363653327764397 0.294665626627918 no 973 0.358058449720041 1739 4293482
SGTC_3325 9138760 55.175 µM 0.36316026532686 0.294855903206936 no 974 0.358242583953682 1621 43844959
SGTC_1054 3429-0080 167 µM 0.362341793567943 0.295171882711403 no 975 0.358548315121915 1741 1162877
SGTC_946 3434-1334 87.4 µM 0.359387984752502 0.296313525707754 no 976 0.359652430970793 1747 4047976
SGTC_214 4373-3496 70 µM 0.359094207443468 0.296427180845048 no 977 0.359762307405018 1759 3779166
SGTC_850 0388-0143 75.9 µM 0.356785354325731 0.297321113497188 no 978 0.360626250603516 1671 67273
SGTC_683 panaxydol 45 µM 0.356016553622373 0.297619047835555 no 979 0.360914084163926 1770 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1263 0774-1208 64.8 µM 0.354054737771895 0.298379929660194 no 980 0.361648930895829 1829 906585
SGTC_1796 st049173 110.4 µM 0.353662013076984 0.298532352536266 no 981 0.361796097076758 1779 94134
SGTC_502 l-744,832 89.3 µM 0.353308291798342 0.298669667858449 no 982 0.361928664959959 1812 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_123 0083-0120 66.675 µM 0.35294571462684 0.298810450853305 no 983 0.362064569055936 1642 16001701
SGTC_3216 9129716 49.47 µM 0.352637256269724 0.298930244101659 no 984 0.362180201595 1622 8056934
SGTC_1277 0873-0036 22 µM 0.352623269277835 0.298935676623176 no 985 0.362185445231061 1794 5965735
SGTC_2994 9053520 71.4286 µM 0.351601992060299 0.299332459900951 no 986 0.362568385519974 1812 4647384
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.350664573078971 0.299696872969962 no 987 0.362920003210123 1771 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1521 st012942 49.4 µM 0.350637026450012 0.299707584509222 no 988 0.362930337460338 1876 24207259
SGTC_1853 st056710 91.2 µM 0.350272011559341 0.299849537351061 no 989 0.363067283972318 1854 269167
SGTC_1888 azatryptophan 97.5 µM 0.349659757846632 0.300087708708734 no 990 0.363297029007814 1678 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_716 1683-5115 658 µM 0.349159503592398 0.300282374922332 no 991 0.363484783344818 1769 723597
SGTC_1999 st074831 12.5 µM 0.348831844851463 0.300409909186717 no 992 0.363607777288443 1675 17112523
SGTC_3029 9088683 49.47 µM 0.348618768331026 0.300492857863895 no 993 0.363687767810029 1717 25236615
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.342818952196861 0.302754632259167 no 994 0.365867333612118 1801 77254
SGTC_1861 st057647 17.4 µM 0.342411123060275 0.302913961366159 no 995 0.366020759438193 1846 688668
SGTC_400 oxethazaine 37.5 µM 0.341601216767516 0.303230483642564 no 996 0.36632551069291 1707 4621 A local anesthetic.
SGTC_3228 9131799 49.47 µM 0.341508335578027 0.303266792310893 no 997 0.366360465387334 1734 17015818
SGTC_1198 1612-1005 86.7 µM 0.341394605122936 0.303311253920656 no 998 0.3664032679567 1811 6998509
SGTC_711 k292-0785 179 µM 0.338880521892941 0.304294848813447 no 999 0.36734986921623 1676 4146315
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.338582486766462 0.304411544410813 no 1000 0.367462138836386 1689 2374 Ca(2+)-ATPase inhibitor.
SGTC_2602 kawain 100 µM 0.338253973885198 0.304540196642114 no 1001 0.367585902531514 1740 5369129
SGTC_1171 0368-0077 21.4 µM 0.337596701523495 0.304797670264926 no 1002 0.367833564099776 1704 3239779
SGTC_705 1124-0212 310 µM 0.336365710291297 0.305280147154123 no 1003 0.368297551894735 1846 9554485
SGTC_927 2425-1185 123 µM 0.336060428032297 0.305399852441071 no 1004 0.36841264928449 1652 730375
SGTC_668 1682-0499 62.6 µM 0.33363169242286 0.306352932926778 no 1005 0.369328750066024 1709 682214
SGTC_205 1486-1330 71.903 µM 0.332779064043321 0.306687831376237 no 1006 0.369650531428848 1754 4118834
SGTC_1509 1326-1131 80 µM 0.330494310672314 0.307586040454073 no 1007 0.370513245391345 1842 768313
SGTC_1195 1502-0147 41.1 µM 0.330183119078131 0.307708469219065 no 1008 0.370630800638413 1708 817940
SGTC_3353 9151644 39.2805 µM 0.329180234812699 0.308103168866742 no 1009 0.37100973076226 1747 4909158
SGTC_1243 0416-0003 5.65 µM 0.325869287957137 0.309407814683411 no 1010 0.372261626549183 1727 2141977
SGTC_1507 4075-3230 155 µM 0.3250670727917 0.309724282362481 no 1011 0.372565154448814 1841 659771
SGTC_2017 5132927 60.65 µM 0.322622644059789 0.310689459816628 no 1012 0.373490521272365 1669 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2003 4023581 200 µM 0.321776753241356 0.3110237621276 no 1013 0.373810913325592 1733 16641307
SGTC_1409 3909-8004 61.9 µM 0.32097001792574 0.311342735238528 no 1014 0.374116555986531 1763 2119279
SGTC_1691 st019933 84.6 µM 0.320885670614776 0.311376093301888 no 1015 0.374148516687549 1875 6176082
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.31878067564538 0.312209087460718 no 1016 0.374946416489433 1817 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1934 st074720 32.6 µM 0.318503636925823 0.312318789597589 no 1017 0.375051468160052 1660 17250992
SGTC_2397 5161689 200 µM 0.318159658701688 0.312455021677686 no 1018 0.375181915849179 1814 2259942
SGTC_307 1501-1223 22.3 µM 0.317812633771379 0.312592486379364 no 1019 0.375313533415192 1765 2830329
SGTC_1423 4048-0112 5.59 µM 0.317665377403255 0.312650825956662 no 1020 0.375369388328603 1855 X1423
SGTC_2172 5754775 163.918 µM 0.317574069368519 0.31268700245232 no 1021 0.375404023133888 1697 2263357
SGTC_2250 alverine citrate 130 µM 0.313518751833814 0.314295546136132 no 1022 0.376943288199859 1733 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1682 st012968 530 nM 0.312789054755356 0.314585356764372 no 1023 0.377220465742828 1686 24207270
SGTC_2180 6301957 200 µM 0.311294663257345 0.315179234281904 no 1024 0.377788311995489 1875 845462
SGTC_2107 5363541 170.161 µM 0.310128134466651 0.315643150060202 no 1025 0.378231759044551 1797 244052
SGTC_278 4092-0821 23.9 µM 0.309192926446243 0.316015282055329 no 1026 0.378587387171635 1826 877900
SGTC_2757 clomiphene 4.22 µM 0.306113808207671 0.317241821374237 no 1027 0.379758997418236 1904 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1893 st059353 36.1 µM 0.305633700667845 0.31743324941402 no 1028 0.379941779055501 1737 3112488
SGTC_3270 9137563 49.47 µM 0.304169713886777 0.318017270229565 no 1029 0.380499298580645 1843 17015724
SGTC_2674 ligustilide 100 µM 0.304098892863643 0.318045533995334 no 1030 0.380526275145557 1782 5319022 A signalling regulator.
SGTC_1534 6-azauridine 81.6 µM 0.303311533217114 0.318359830526138 no 1031 0.380826228849729 1777 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1043 0916-0009 19.3 µM 0.30257898570233 0.318652364727064 no 1032 0.38110536558065 1943 3101130
SGTC_2982 9019404 25.97 µM 0.300905118060174 0.319321228110862 no 1033 0.381743423721375 1571 22333232
SGTC_2909 7941780 10.49 µM 0.300904035228695 0.31932166099186 no 1034 0.381743836587882 1929 1243215
SGTC_2861 9024595 19.48 µM 0.300740528382918 0.31938702856576 no 1035 0.381806180704234 1868 16482810
SGTC_1671 st016596 74.5 µM 0.298483311909794 0.320290002647927 no 1036 0.382667155565027 1772 2829167
SGTC_458 nppb 133 µM 0.296941504684612 0.320907397961467 no 1037 0.383255584149595 1943 4549 A chloride channel blocker.
SGTC_1092 toremifene 6.32 µM 0.296830063375384 0.320952042311543 no 1038 0.383298126027771 1808 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3251 9135047 49.47 µM 0.296730777246309 0.320991819372225 no 1039 0.383336028943137 1894 17682963
SGTC_2795 7780010 54.55 µM 0.294064301682471 0.322060858317604 no 1040 0.384354384299348 1796 953673
SGTC_3281 9140613 49.47 µM 0.293412420582742 0.32232243396924 no 1041 0.384603466389419 1697 16013766
SGTC_2717 st081029 62.2815 µM 0.292931575206925 0.322515435750477 no 1042 0.384787226709872 1917 5292846
SGTC_402 epigallocatechin gallate 10 µM 0.291833635974825 0.32295630600853 no 1043 0.385206913167572 1767 65064 An antioxidant.
SGTC_3145 9085516 49.47 µM 0.291688708297586 0.323014519368954 no 1044 0.3852623217232 1728 25236195
SGTC_3075 9116269 49.47 µM 0.291398382513107 0.32313114808927 no 1045 0.385373325733706 1806 17015205 YNL244C SUI1
SGTC_2646 retinol 96.75 µM 0.288254459419373 0.32439522624651 no 1046 0.386575982192008 1815 445354 A vitamin A analog and teratogen.
SGTC_322 k048-0136 19.3 µM 0.287999670193265 0.324497758381629 no 1047 0.386673495562384 1834 6823282
SGTC_259 usnic acid 108.925 µM 0.287569167914417 0.324671031092261 no 1048 0.386838274390843 1878 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_682 0kpi-0099 17 µM 0.287333681315077 0.324765828070737 no 1049 0.38692841775272 1762 1714895 YML126C ERG13
SGTC_3067 9117431 49.47 µM 0.286514561098218 0.325095659717205 no 1050 0.38724202129172 1780 17150885
SGTC_810 3825-7150 143 µM 0.286077950669866 0.325271523812691 no 1051 0.387409209473603 1966 22330411 YGL099W LSG1
SGTC_1902 st060212 70.5 µM 0.285322645257697 0.325575848250635 no 1052 0.387698482595913 1816 688944
SGTC_1221 2958-7315 257 µM 0.284157616881276 0.326045484522862 no 1053 0.388144797009501 1836 4562705
SGTC_387 norethindrone acetate 66.7 µM 0.283255919264295 0.326409158720639 no 1054 0.388490332685947 1768 541197
SGTC_950 1165-0508 94.1 µM 0.283057272825129 0.326489299337732 no 1055 0.388566467009338 1754 6148369
SGTC_996 3970-0799 1.8 µM 0.28228164756128 0.326802289168763 no 1056 0.38886377836582 1930 6615648 YGL040C HEM2
SGTC_988 1497-1057 103 µM 0.281665627761392 0.32705095991901 no 1057 0.389099956421025 1977 3533044
SGTC_2322 7413319 38.22 µM 0.28150350073639 0.327116419043063 no 1058 0.389162121702316 1812 1840400
SGTC_558 k064-0027 21.3 µM 0.278827689436777 0.328197550414097 no 1059 0.390188531864923 1869 5088526
SGTC_2415 st077333 57.7 µM 0.278468493088438 0.328342789519759 no 1060 0.390326373885744 2018 2766255
SGTC_862 0452-0056 10.2 µM 0.276470289699849 0.329151225433909 no 1061 0.391093438032948 1907 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1730 st033808 45.1 µM 0.275747556051046 0.329443827137678 no 1062 0.391370983325175 1805 1045166
SGTC_812 4251-0442 148 µM 0.275273837174884 0.329635670871068 no 1063 0.391552931600226 1939 5723007
SGTC_1336 1486-0901 104 µM 0.274473785148278 0.329959772769955 no 1064 0.391860273373058 1860 5006114
SGTC_3086 9117350 49.47 µM 0.271455238585144 0.331183737031438 no 1065 0.393020461010109 1821 2679265
SGTC_203 k066-0004 30.888 µM 0.2711036237196 0.331326427970365 no 1066 0.393155667294102 1978 6795412
SGTC_3020 9089140 49.47 µM 0.269565322865935 0.331950982802418 no 1067 0.393747340672044 1801 17217859
SGTC_1302 1159-0335 255 µM 0.26806440722861 0.332560809520377 no 1068 0.394324871192122 1798 649284
SGTC_2218 6965428 192.983 µM 0.26801868019915 0.332579395523448 no 1069 0.394342469942697 1910 675684
SGTC_229 benomyl 22.8748 µM 0.267800811543531 0.332667955090138 no 1070 0.394426323007033 1816 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2123 5259487 200 µM 0.267515007688619 0.332784143214823 no 1071 0.394536330319317 1916 2173474
SGTC_2177 5811945 192 µM 0.266875158884077 0.333044319796803 no 1072 0.394782641759011 1907 5343475
SGTC_38 0929-0051 58.268 µM 0.266286045387091 0.333283937371301 no 1073 0.395009459706917 1982 1379719
SGTC_3139 9095020 49.47 µM 0.264952510339863 0.333826594202213 no 1074 0.395523022970719 1868 25236292
SGTC_856 0433-0016 11.3 µM 0.264945058284345 0.333829627653103 no 1075 0.395525893373726 1835 3911780
SGTC_187 1488-2104 32.728 µM 0.264620747476101 0.333961652875898 no 1076 0.39565081778075 1917 2852859
SGTC_1603 st002045 67.8 µM 0.264457996629227 0.334027915635248 no 1077 0.395713513389587 1949 5887985
SGTC_2407 paclitaxel 400 µM 0.264216537913753 0.334126233232442 no 1078 0.39580653416662 1897 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2828 7998861 71.43 µM 0.263415211265602 0.334452600413749 no 1079 0.396115283799361 1975 2988188
SGTC_442 cape 100 µM 0.262734519386172 0.334729933360392 no 1080 0.396377604291095 1962 5281787
SGTC_2859 9028643 45.46 µM 0.262647301593519 0.334765474853842 no 1081 0.396411219095041 1930 17151580
SGTC_2376 9072922 81.32 µM 0.261077561635045 0.335405401065433 no 1082 0.397016347489462 1887 17087968
SGTC_2350 9023895 38.85 µM 0.260341329562689 0.335705700985169 no 1083 0.397300247506349 1894 2997209
SGTC_3262 9137218 49.47 µM 0.256476436717169 0.337283860577774 no 1084 0.398791486431519 1878 17650664
SGTC_958 1222-0007 33 µM 0.256334916445369 0.337341702421478 no 1085 0.398846119125857 1907 7312461
SGTC_80 0159-0065 512.242 µM 0.25561357273328 0.337636588095124 no 1086 0.399124618490797 1969 1548079
SGTC_2029 5175081 200 µM 0.252048402768283 0.339095492701405 no 1087 0.400501825600485 1871 1380876
SGTC_1115 galangin 695.678 nM 0.251184320189458 0.339449448855523 no 1088 0.400835803353344 1962 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2788 5282734 71.43 µM 0.251068978584083 0.339496707230317 no 1089 0.400880389686295 1957 743706
SGTC_1201 1889-3372 45.9 µM 0.25064812242224 0.339669164052492 no 1090 0.401043086360163 1852 5392199
SGTC_894 0960-0238 55.9 µM 0.249431206205029 0.340168016077583 no 1091 0.401513624368675 1973 6741907 YDL195W SEC31
SGTC_2447 5741742 33.78 µM 0.248587873703835 0.34051388870978 no 1092 0.40183979474442 1909 1776504
SGTC_1330 1469-0054 61.8 µM 0.247940738046019 0.340779386904915 no 1093 0.402090129692186 2003 7102664
SGTC_2860 9025725 38.96 µM 0.247686699247655 0.340883632128864 no 1094 0.402188411864381 1781 40546248
SGTC_513 4245-1575 41.7 µM 0.247633248788153 0.34090556715719 no 1095 0.40220909149049 1949 719745
SGTC_2037 5169046 200 µM 0.247405827858247 0.340998902292523 no 1096 0.402297082189953 1904 5718022
SGTC_1661 st013063 9.66 µM 0.247372373801536 0.341012632891844 no 1097 0.402310026209096 1861 721395
SGTC_1154 4088-0362 150 µM 0.247109124968621 0.341120685856719 no 1098 0.402411885991745 1843 6618304
SGTC_1117 retinoic acid 1.10837 µM 0.245615239535232 0.341734111773367 no 1099 0.402990045557159 1996 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3297 9117502 71.43 µM 0.244814462989345 0.342063102479018 no 1100 0.403300047392918 1954 7453720
SGTC_3009 9080819 71.4286 µM 0.244245927203286 0.3422967523091 no 1101 0.403520179577602 1847 17027216
SGTC_584 0986-0246 15.4 µM 0.243264917258622 0.34270005762366 no 1102 0.403900090067827 1981 53315 YDR232W HEM1
SGTC_3090 9117696 49.47 µM 0.242200613613921 0.343137808858262 no 1103 0.404312359803851 1978 7923821
SGTC_2870 9038528 12.99 µM 0.24188323538216 0.343268388252144 no 1104 0.404435320349766 1882 6463316
SGTC_2853 9015042 58.44 µM 0.241494259659516 0.343428450629001 no 1105 0.404586032490934 1833 6457456
SGTC_2933 9026794 32.47 µM 0.241294771169263 0.343510550458459 no 1106 0.404663331593896 1916 17586027
SGTC_3324 9138759 60.749 µM 0.241253147968065 0.343527681489235 no 1107 0.404679460492992 1906 45595710
SGTC_1792 st045773 43.6 µM 0.240888412870417 0.343677810746389 no 1108 0.404820801467668 1855 2919270
SGTC_3204 9114183 49.47 µM 0.240033489638941 0.344029803807919 no 1109 0.405152147213887 1805 17027248
SGTC_3218 9131285 49.47 µM 0.239593362802307 0.344211067661599 no 1110 0.40532275532353 1986 17156417
SGTC_1347 1493-0251 600 nM 0.239462517619944 0.344264962445975 no 1111 0.405373478830899 1973 3986378
SGTC_1948 st076329 66.6 µM 0.239384588833697 0.344297062609716 no 1112 0.405403689497492 1981 24208413
SGTC_1252 0493-0875 34.8 µM 0.23841107689245 0.344698162844031 no 1113 0.40578113848734 1849 3960963
SGTC_751 0833-0568 350 µM 0.238235346323162 0.344770584862721 no 1114 0.405849281897322 1897 6954252
SGTC_2619 obliquin 87.91 µM 0.237222278345426 0.345188200924519 no 1115 0.406242176951977 1952 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2730 imipramine 71.33 µM 0.236693915699663 0.345406082225704 no 1116 0.40644712771358 1994 3696 A tricyclic antidepressant.
SGTC_2005 4024620 188 µM 0.235104737263177 0.346061721496172 no 1117 0.407063720968578 1894 236743
SGTC_3054 9094397 49.47 µM 0.234776898528278 0.346197033772586 no 1118 0.407190949470076 1855 2598354
SGTC_1333 1482-0047 286 µM 0.234677695872307 0.346237982582993 no 1119 0.407229450223179 2001 3811116
SGTC_1983 st071813 46.9 µM 0.23294460977034 0.346953654431986 no 1120 0.407902208769538 1892 11838595
SGTC_507 nimesulide 162 µM 0.232340278734737 0.347203339416416 no 1121 0.408136865170106 2006 4495 A COX2 inhibitor.
SGTC_237 nikkomycin 200 µM 0.232193370639285 0.347264045888584 no 1122 0.408193913267005 1983 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_867 0518-0118 155 µM 0.231903546297204 0.347383820781471 no 1123 0.40830646503125 2047 6848158
SGTC_3307 9126885 69.2785 µM 0.226502895267354 0.34961850942812 no 1124 0.410405153822342 1836 24824909
SGTC_1980 st071811 45.7 µM 0.224662031275575 0.350381421708688 no 1125 0.411121102088268 1970 4974850
SGTC_1785 bathophenanthroline 24 µM 0.224637090829393 0.350391761972606 no 1126 0.411130803957628 1838 72812 An iron chelator.
SGTC_1687 st020778 55.3625 µM 0.223270209816636 0.350958637743063 no 1127 0.411662605598566 1933 4259299
SGTC_1061 3448-9325 110 µM 0.22296106180742 0.351086894320349 no 1128 0.411782905923737 2041 723482
SGTC_1232 0279-0259 161 µM 0.222643575794446 0.351218627752218 no 1129 0.41190645948913 1851 1560000
SGTC_3185 9108267 49.47 µM 0.222277932831745 0.351370364940745 no 1130 0.412048764741283 1847 4910486
SGTC_898 1000-0849 28.3 µM 0.222218589973872 0.351394993708713 no 1131 0.412071861587862 2031 6751807
SGTC_2641 levomentholum 100 µM 0.222070113745381 0.351456617784783 no 1132 0.412129651387157 1974 16666
SGTC_2591 skatole 100 µM 0.221675231008022 0.351620530249216 no 1133 0.412283356601069 1901 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_250 brefeldin a 552.239 µM 0.220053629910236 0.352293932064269 no 1134 0.412914693786362 1923 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1261 0712-0010 12.7 µM 0.220041922972189 0.352298795288062 no 1135 0.412919252464121 2019 2840123
SGTC_2908 7930301 100 µM 0.219797550249728 0.352400316605502 no 1136 0.413014413800611 1932 2223178
SGTC_2054 5233173 129 µM 0.219461708102004 0.352539854805985 no 1137 0.413145202642202 1936 6889
SGTC_2787 5284540 71.43 µM 0.218697709004345 0.352857360749106 no 1138 0.413442766869685 1895 736958
SGTC_1799 st045822 46.1415 µM 0.217914001873259 0.353183163544147 no 1139 0.413748058691631 2031 3674992
SGTC_2611 pyromycin 23.93 µM 0.216905782124679 0.353602459036351 no 1140 0.414140885697091 1861 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_831 k061-1017 217 µM 0.215681745860119 0.35411174645845 no 1141 0.414617915515661 2007 1240153
SGTC_467 ro 31-8220 72.8 µM 0.214580995934829 0.35456996086589 no 1142 0.4150470059254 2034 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3043 9092303 49.47 µM 0.213865676186104 0.354867843330207 no 1143 0.415325903687713 1856 25236084
SGTC_314 1671-0008 2.74 µM 0.213638527477328 0.354962454032353 no 1144 0.415414476184725 1950 3913060
SGTC_2361 9034121 116 µM 0.212214678904301 0.355555710972254 no 1145 0.415969777715069 1916 6496917
SGTC_817 1391-0715 46 µM 0.209313185740599 0.356765721718392 no 1146 0.417101879512205 1882 1353946
SGTC_183 3914-0051 30.55 µM 0.209058859433006 0.35687185245478 no 1147 0.41720114522142 2077 1596232
SGTC_395 anisomycin 6.25 µM 0.206987030747981 0.357736841653655 no 1148 0.418009993568175 1917 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_91 0417-1751 58.384 µM 0.206801324055479 0.357814410030741 no 1149 0.418082511029021 2070 6795624
SGTC_1722 st034304 3.6505 µM 0.205358322559473 0.358417341445966 no 1150 0.418646090036673 1919 4036148 YLR033W RSC58
SGTC_1843 st055809 45.5 µM 0.203239599169153 0.359303250299731 no 1151 0.419473881499988 1943 16413835
SGTC_1666 st014829 29 µM 0.202733982612026 0.359514777482442 no 1152 0.419671480204213 1922 3858230
SGTC_2416 tofa 880 nM 0.200554874986612 0.360426909809347 no 1153 0.420523322801667 1801 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2002 4023503 131 µM 0.200155149957737 0.360594313409067 no 1154 0.420679621244986 2125 4736863 YCR052W RSC6
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.200092865017494 0.360620400555422 no 1155 0.420703976711562 1976 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1967 st070177 51.4 µM 0.198343493152023 0.361353364214635 no 1156 0.421388162479549 2026 5729214
SGTC_1490 4089-0339 670 nM 0.195666047044213 0.362476164031233 no 1157 0.422435780604919 2058 742542
SGTC_2563 tomatine 8.54 µM 0.195024338507381 0.362745443811749 no 1158 0.422686947034699 2175 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_393 acivicin 6.25 µM 0.194293357283109 0.363052267753219 no 1159 0.42297309332548 1962 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2219 9098279 200 µM 0.193395653158254 0.363429192664021 no 1160 0.423324559726777 2061 902349
SGTC_1321 1326-2144 215 µM 0.193141905839071 0.363535759205053 no 1161 0.42342391718329 2060 3513030
SGTC_1239 0337-0584 35.4 µM 0.193026713924533 0.363584139965874 no 1162 0.423469023407695 2078 914301 YML130C ERO1
SGTC_2391 6285546 200 µM 0.19248315112482 0.36381246642442 no 1163 0.4236818823002 1898 846083
SGTC_1997 st073024 93.8 µM 0.192443649417231 0.36382906121394 no 1164 0.42369735201591 2084 686268
SGTC_2464 5717415 7.67 µM 0.192424989612276 0.363836900344535 no 1165 0.423704659636542 1875 5285744
SGTC_2460 5552655 174.22 µM 0.191365433347976 0.364282121657887 no 1166 0.424119649882618 1929 5401989
SGTC_1746 st038117 42 µM 0.191139338846933 0.364377149401739 no 1167 0.424208213911909 1931 2898218
SGTC_81 0411-0046 9.971 µM 0.190483699814628 0.364652762260845 no 1168 0.424465057505259 1997 12925265
SGTC_1134 3477-0009 42.5 µM 0.189513133247895 0.365060890535965 no 1169 0.424845331381557 2111 3973534
SGTC_3201 9113999 49.47 µM 0.187571823345653 0.365877679818689 no 1170 0.425606157935922 2014 16649224
SGTC_2595 hexamethylquercetagetin 100 µM 0.187187172698317 0.366039590561348 no 1171 0.425756940893463 1978 386331
SGTC_3196 9111891 49.47 µM 0.187013509986312 0.366112698110895 no 1172 0.425825020191815 2070 18891510
SGTC_3042 9091578 49.47 µM 0.185957802614806 0.366557228349532 no 1173 0.426238926354319 2067 25236497
SGTC_800 3448-7362 155 µM 0.185063881826195 0.36693377461019 no 1174 0.426589465177774 2115 15991913
SGTC_1860 st056228 74.6 µM 0.184797102688159 0.367046174816601 no 1175 0.426694090220602 1951 688679
SGTC_2710 st078562 53.7235 µM 0.184796386344447 0.367046476644083 no 1176 0.426694371162154 2040 17250908
SGTC_2199 6590217 200 µM 0.184706103272823 0.367084517577299 no 1177 0.426729779415202 2048 703109
SGTC_35 0133-0054 64.071 µM 0.184458459732682 0.367188869322396 no 1178 0.426826906136309 1909 99677
SGTC_2847 9005661 71.43 µM 0.183884773760425 0.367430646124491 no 1179 0.42705192495139 2106 2991449
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.183779726221317 0.367474923529227 no 1180 0.427093130681186 2068 91467 include heat shock
SGTC_496 calpeptin 138 µM 0.183279417540365 0.367685827173929 no 1181 0.427289391635776 1951 73364 A calpain inhibitor.
SGTC_23 0213-0011 39.996 µM 0.181862136839943 0.368283494114774 no 1182 0.427845459673341 2092 627608
SGTC_1694 st024011 44.9 µM 0.18161742979291 0.368386719342087 no 1183 0.427941484671846 2078 2787533
SGTC_849 0386-0493 241 µM 0.180020980433321 0.369060385390434 no 1184 0.428568048634042 1980 726119
SGTC_1387 3342-1166 1.8 µM 0.179534613801903 0.369265701336403 no 1185 0.428758970478736 1990 3418228
SGTC_1501 4491-0275 38.4 µM 0.17840676037704 0.369741959457444 no 1186 0.429201770231811 2110 5104718
SGTC_3081 9117243 49.47 µM 0.178391795392649 0.369748280059445 no 1187 0.429207646144585 2089 45595589
SGTC_1077 5-fluorocytosine 377 nM 0.177495835647346 0.370126761158565 no 1188 0.429559467987192 2001 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1102 cgs 12066b 26.1 µM 0.175367627233628 0.371026285894981 no 1189 0.430395388050503 2000 6438352 A 5-HT1B full agonist.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.174667572842618 0.371322330576951 no 1190 0.430670424573654 1970 5282362
SGTC_3080 9117754 49.47 µM 0.172750082135957 0.372133604071305 no 1191 0.431423937841713 2107 9550191
SGTC_2204 7233102 200 µM 0.171624266134118 0.372610191792606 no 1192 0.431866464448407 2052 2172480
SGTC_355 1311-2252 105 µM 0.171503659539071 0.372661259340394 no 1193 0.431913876589525 1960 5338538
SGTC_3006 9075424 71.4286 µM 0.17108117945068 0.37284016457054 no 1194 0.432079967157652 1964 7465181
SGTC_1884 5633444 25 µM 0.169810153862034 0.373378563776698 no 1195 0.432579720640468 2027 5724239
SGTC_2608 thymoquinone 42.66 µM 0.169310007817109 0.373590490652818 no 1196 0.432776402262936 2117 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1955 wogonin 32.4 µM 0.167463769254464 0.374373127889987 no 1197 0.433502576437266 2078 5281703 A flavanone.
SGTC_1179 1021-1431 9.29 µM 0.167429401828471 0.374387701473132 no 1198 0.43351609618598 2036 2840958
SGTC_2825 7998094 58.44 µM 0.166559411445641 0.3747566825463 no 1199 0.433858366229895 2013 2987815
SGTC_2782 7736369 71.43 µM 0.166436525253619 0.374808810395993 no 1200 0.433906715897079 1982 2950836 YOL077C BRX1
SGTC_3129 9127257 49.47 µM 0.165367252577535 0.375262488200726 no 1201 0.434327463719019 1864 837894
SGTC_1010 4112-3296 15.2 µM 0.165346943357703 0.375271106797733 no 1202 0.434335455910049 2146 704384
SGTC_1464 k208-0027 110 µM 0.165295478352366 0.375292947213405 no 1203 0.434355708809862 2101 X1464
SGTC_2893 9048488 25.97 µM 0.164606995330767 0.375585160000452 no 1204 0.434626662426576 1959 6467338
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.164088059013446 0.375805459285446 no 1205 0.434830910964207 2018 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2263 7948595 193.29 µM 0.163979282073324 0.375851642499611 no 1206 0.43487372676913 1963 2971371
SGTC_2746 daunorubicin 9.88 µM 0.163162730043524 0.376198381148974 no 1207 0.435195155015899 2104 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2162 5663267 200 µM 0.162393208669112 0.376525240306065 no 1208 0.435498109276508 2107 6456493
SGTC_544 k015-0020 52.4 µM 0.162127061893413 0.376638308483354 no 1209 0.435602897902262 2005 3008304
SGTC_2040 5100729 123 µM 0.161264721352806 0.377004732648278 no 1210 0.435942453910902 2041 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3132 9126706 49.47 µM 0.161166384498901 0.377046524808243 no 1211 0.435981178125656 2046 850858
SGTC_2948 9070189 9.45 µM 0.160865035894957 0.377174603859922 no 1212 0.436099850457451 2145 6473636 YDL196W YDL196W
SGTC_2977 9011197 71.43 µM 0.159818789236344 0.377619383977913 no 1213 0.436511911329454 2101 2704722
SGTC_1000 4048-0884 8.67 µM 0.158380562802913 0.378231067297507 no 1214 0.437078464548334 2043 13040088
SGTC_481 bay k-8644 50 µM 0.158354971666605 0.378241954076889 no 1215 0.43708854670652 1986 2303 A calcium channel antagonist.
SGTC_2205 7238770 200 µM 0.157444574685128 0.378629310808635 no 1216 0.437447242985804 2132 279867
SGTC_2617 dihydrotanshinone i 20.83 µM 0.15739717426234 0.378649482137649 no 1217 0.437465920156302 2024 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2552 juarezic acid 87.02 µM 0.155078731594693 0.379636501827145 no 1218 0.438379624528039 2175 1549512
SGTC_2910 7948405 25.97 µM 0.152655206576375 0.38066909670832 no 1219 0.439335093303328 2120 2971328
SGTC_1907 st060210 83.7 µM 0.151695729058842 0.381078138181953 no 1220 0.439713462952846 2111 688793
SGTC_1306 1185-0270 9.02 µM 0.151167401599439 0.381303429877527 no 1221 0.43992183225066 2116 1548076
SGTC_3322 9139058 2.11 µM 0.149449479089088 0.382036271594427 no 1222 0.440599485706332 2096 4908926 YPR165W RHO1
SGTC_1016 4226-1401 38 µM 0.148601338805047 0.382398232464912 no 1223 0.440934108263844 2142 2901613
SGTC_2353 9059630 146.67 µM 0.148568136772981 0.382412404190253 no 1224 0.440947208546876 2106 4779114
SGTC_548 1436-0017 110 µM 0.147477308305734 0.382878093337511 no 1225 0.441377644613531 2152 9677137
SGTC_2833 9001315 45.46 µM 0.147281657989358 0.382961636985085 no 1226 0.44145485469789 1995 2989378
SGTC_1908 st060353 56.5 µM 0.145948875033373 0.383530886553456 no 1227 0.441980873974383 2170 4227716
SGTC_109 0132-0036 33.701 µM 0.145003489704534 0.38393482591661 no 1228 0.442354058263487 2161 67274 A color developer.
SGTC_3190 9110366 49.47 µM 0.144824636218578 0.384011259712178 no 1229 0.442424665199192 2150 17123768
SGTC_1085 doxorubicin 7.67 µM 0.143871037130333 0.38441886041416 no 1230 0.442801153367365 2157 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_987 1497-1013 404 µM 0.14347582403298 0.384587825434104 no 1231 0.442957201661869 2141 1676435
SGTC_549 1661-1316 519 µM 0.143388160982089 0.384625306893942 no 1232 0.442991816263182 2170 2857282
SGTC_3253 9135987 49.47 µM 0.143294333670933 0.384665425157087 no 1233 0.443028865364191 2093 4182430
SGTC_2 0422-0095 29 µM 0.142968541493127 0.3848047355103 no 1234 0.443157513087906 2081 6790840
SGTC_2652 actinonin 100 µM 0.141731045392711 0.385334030394947 no 1235 0.443646225897593 2147 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1499 4480-0877 67.3 µM 0.141706358444287 0.385344591534845 no 1236 0.443655976158766 2158 2861909
SGTC_727 3032-0951 202 µM 0.141692243247751 0.385350630090358 no 1237 0.443661551057241 2069 3652836
SGTC_418 lividomycin a 100 µM 0.141165859666213 0.385575839596468 no 1238 0.443869457993266 2170 72394 An antibiotic.
SGTC_383 2324-0395 7.37 µM 0.140098582574141 0.386032584929778 no 1239 0.444291050245378 2093 3146421
SGTC_216 k038-0035 28.382 µM 0.139780529975475 0.386168727351147 no 1240 0.444416698540655 2137 4444231 YPR107C YTH1
SGTC_941 3237-0776 460 µM 0.13865361967697 0.38665121404139 no 1241 0.444861935055788 2146 760008
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.138635120509966 0.386659135924668 no 1242 0.444869244564329 2087 7104
SGTC_3135 9127742 49.47 µM 0.138483109838287 0.386724233119552 no 1243 0.444929308697554 2007 3643468
SGTC_700 3453-2283 142 µM 0.137298352613123 0.387231703775344 no 1244 0.445397486265125 2134 565664
SGTC_2892 9047358 58.44 µM 0.13715816227894 0.387291764698527 no 1245 0.445452889982815 2054 6466771
SGTC_2045 5106652 78.05 µM 0.136864897221836 0.387417415251966 no 1246 0.445568792818359 2138 673349
SGTC_3158 9100007 49.47 µM 0.136677729570122 0.387497614126369 no 1247 0.445642766769358 2038 19297233
SGTC_781 4335-2806 94.4 µM 0.134669356942333 0.388358476844756 no 1248 0.44643665102896 2160 845254
SGTC_2143 5623677 140.463 µM 0.133754554848793 0.388750776980225 no 1249 0.446798332083506 2149 5375313
SGTC_3014 9081533 49.47 µM 0.131684140974114 0.389639063602935 no 1250 0.44761706496973 2182 21367265
SGTC_2315 7733312 200 µM 0.131479440429343 0.389726919364124 no 1251 0.447698024769735 2070 726316
SGTC_2059 5238311 157 µM 0.130924894226072 0.38996495425313 no 1252 0.447917360720764 2079 703021
SGTC_2513 baicalein 25.65 µM 0.130667413068075 0.390075490185999 no 1253 0.448019205938927 2047 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1810 st050138 53 µM 0.129508486123913 0.390573124167298 no 1254 0.448477655273172 2189 3444541
SGTC_1916 st067606 49.2 µM 0.128644740602269 0.390944126262947 no 1255 0.448819381271153 2138 19590279
SGTC_1879 gemcitabine 100 µM 0.128313823633486 0.391086290385384 no 1256 0.448950312929315 2146 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2561 acetosyringone 100 µM 0.128052822840926 0.391198428322763 no 1257 0.449053585253751 2218 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.12699187370961 0.391654353856031 no 1258 0.449473415158004 2204 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3355 9151058 44.0485 µM 0.126942241622009 0.391675686083265 no 1259 0.449493056540687 2200 17015728
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.126443596137704 0.391890025553937 no 1260 0.449690397166313 2173 3256 An antibiotic and ribosome inhibitor.
SGTC_1781 st038725 66.3 µM 0.124218949099915 0.392846674322698 no 1261 0.450570959612931 1995 4270275 YIL048W NEO1
SGTC_2109 5483026 200 µM 0.122951236795131 0.393392109469765 no 1262 0.451072856143247 2074 759335
SGTC_1125 tnp00248 1.32998 µM 0.120777125483001 0.394328010883446 no 1263 0.451933784336194 2201 24207736
SGTC_2737 bleomycin 30.5 nM 0.118867979152125 0.395150354967887 no 1264 0.452689975396127 2160 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1 0258-0098 57.368 µM 0.118773518890755 0.395191054861291 no 1265 0.452727394505236 2088 6790032 YDR047W HEM12
SGTC_452 diindolylmethane 8 µM 0.118611137745538 0.395261022354579 no 1266 0.452791720501847 2147 3071 Inhibits expression of several cancer promoting factors.
SGTC_924 2046-0044 21.3 µM 0.11844743872911 0.395331561115968 no 1267 0.4528565698167 2214 3623589
SGTC_1956 st077085 54 µM 0.118028926354904 0.395511915871785 no 1268 0.453022369077313 2083 24208685
SGTC_1896 st058441 89 µM 0.117951674818134 0.395545209287652 no 1269 0.453052974200522 2045 688759
SGTC_1452 4194-0072 190 µM 0.117900262387286 0.395567367139146 no 1270 0.453073342671972 2190 1343545
SGTC_892 0929-0076 29 µM 0.117819290614555 0.395602265230436 no 1271 0.453105422153217 2048 5751038
SGTC_2154 5570129 200 µM 0.117308134714262 0.395822588044555 no 1272 0.453307939485641 2193 673366
SGTC_417 st075190 100 µM 0.116710317277433 0.396080306690054 no 1273 0.453544807075015 2217 222757
SGTC_3260 9137109 49.47 µM 0.116569063762054 0.396141207612895 no 1274 0.453600777046007 2201 17478346
SGTC_2148 5546263 113.568 µM 0.116477459480032 0.396180703810213 no 1275 0.45363707461063 2093 792097
SGTC_2309 7664088 163.95 µM 0.116203634735225 0.3962987727237 no 1276 0.453745578084154 2230 704922
SGTC_1819 st053448 58.6 µM 0.113015619281268 0.397674092066341 no 1277 0.45500908607732 2126 2857616
SGTC_3288 9119690 36.221 µM 0.112310780381176 0.397978334072761 no 1278 0.455288497188561 2089 17595618 YKL019W RAM2
SGTC_588 3970-1144 52.9 µM 0.112182580334459 0.398033677987334 no 1279 0.455339320427854 2216 1888707
SGTC_602 3130-1533 38.1 µM 0.110421022063704 0.398794349390133 no 1280 0.456037740937737 2195 720941
SGTC_353 1988-1175 58.3 µM 0.109966436154891 0.398990710010586 no 1281 0.456217996753994 2086 2788357
SGTC_2384 9036245 200 µM 0.109730226369143 0.399092752086457 no 1282 0.456311663990973 2162 6462766
SGTC_1873 rapamycin 2 nM 0.108891870725032 0.399454975393073 no 1283 0.456644127262346 2114 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3021 9087658 49.47 µM 0.10814153699258 0.399779241021146 no 1284 0.456941709789961 2222 25237042
SGTC_1417 3966-0327 90.4 µM 0.106203840539469 0.400616958806179 no 1285 0.457710311936395 2135 651118
SGTC_992 3909-8734 162 µM 0.106199188769708 0.400618970441917 no 1286 0.457712157287992 2127 4288319
SGTC_1051 3253-3903 78 µM 0.10506044770512 0.401111492780403 no 1287 0.458163921860103 2212 5509239
SGTC_2759 disulfiram 3.38 µM 0.104736616736033 0.401251583201602 no 1288 0.458292402893157 2174 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_846 0335-0850 148 µM 0.104394159408292 0.401399745263127 no 1289 0.458428278737723 2221 6819598
SGTC_670 4204-0025 119 µM 0.103920690777137 0.401604611908129 no 1290 0.458616143571411 2169 719039
SGTC_1295 1013-0063 9.78 µM 0.103903519885144 0.401612042144446 no 1291 0.458622956882612 2242 6826038
SGTC_3293 9120939 62.045 µM 0.103531279271709 0.40177312788135 no 1292 0.458770662802184 2177 934087
SGTC_377 3970-0964 33.1 µM 0.10326739401304 0.401887333354145 no 1293 0.458875376520569 2165 16481235
SGTC_782 0083-0095 30.5 µM 0.102107399659365 0.402389460271871 no 1294 0.459335713818499 2257 3591729 An indicator and reagent.
SGTC_184 1494-0393 24.714 µM 0.101436929544735 0.402679760285199 no 1295 0.459601811054664 2154 3090647
SGTC_1514 1189-1591 158 µM 0.101163997003026 0.402797949940419 no 1296 0.459710138141982 2205 767698 YMR146C TIF34
SGTC_309 k408-0051 1.48 µM 0.100786948492625 0.40296124018347 no 1297 0.459859793837405 2159 3640463
SGTC_938 3126-1755 342 µM 0.100401495326586 0.403128187767616 no 1298 0.460012791333929 2228 1777771
SGTC_1021 4476-0760 85.3 µM 0.0995045790065754 0.403516728723026 no 1299 0.460368826211861 2059 746768
SGTC_2438 5259590 200 µM 0.0987337696162249 0.40385071672318 no 1300 0.460674827789001 2210 1201127
SGTC_1169 aniline yellow 25.8 µM 0.0984677406089939 0.403966002099207 no 1301 0.460780443354609 2189 6051 A DNA damaging agent.
SGTC_578 3460-0051 92 µM 0.0967001327780276 0.404732217687058 no 1302 0.461482267192268 2242 2876744
SGTC_2368 9071271 200 µM 0.0965183771717564 0.404811025151664 no 1303 0.461554439596021 2143 27209959
SGTC_3246 9135460 32.98 µM 0.0959911043101786 0.405039667377082 no 1304 0.461763818834575 2209 41446951
SGTC_3015 9080845 49.47 µM 0.0956388107210016 0.405192451114942 no 1305 0.46190371998387 2212 5296973
SGTC_741 4582-0002 126 µM 0.0953102230579342 0.405334967020529 no 1306 0.462034211397887 2166 2912688
SGTC_1209 2323-2347 50.3 µM 0.0935656906878829 0.406091819987385 no 1307 0.462727082438446 2259 5412760
SGTC_2151 5563267 85.4165 µM 0.0919749066055278 0.406782276477112 no 1308 0.463358988347716 2111 5310824
SGTC_180 1486-1293 102.781 µM 0.0913607075974795 0.407048938225745 no 1309 0.463602990964743 2264 4140536
SGTC_149 3970-0822 46.1 µM 0.0901489145281752 0.407575178762184 no 1310 0.46408443962714 2234 3114250 YBL034C STU1
SGTC_2274 7947094 46.08 µM 0.0887717273825565 0.408173446817251 no 1311 0.464631663619811 2268 2971028
SGTC_3342 9147791 14.508 µM 0.0881436944669681 0.408446343679428 no 1312 0.464881234171029 2239 1838168
SGTC_2766 oltipraz 83.91 µM 0.0878200733123347 0.408586982948766 no 1313 0.465009841604394 2233 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1411 3909-8223 150 µM 0.0873608751226231 0.408786561481624 no 1314 0.465192333783013 2275 X1411
SGTC_1253 0550-0034 176 µM 0.0873362411168777 0.408797268679558 no 1315 0.465202123909899 2178 5969915
SGTC_2235 salicylic acid 500 µM 0.0864314578854701 0.40919058081284 no 1316 0.465561720357211 2259 338 A COX inhibitor and kinase inhibitor.
SGTC_1497 4476-2978 41.3 µM 0.0852340498630895 0.409711238388951 no 1317 0.466037660594758 2205 1528379
SGTC_2589 lobaric acid 100 µM 0.0839665812940467 0.410262533227484 no 1318 0.466541501085421 2161 73157 A novel microtubule depolymerizer.
SGTC_911 3456-4043 236 µM 0.0834204895508194 0.41050011461795 no 1319 0.466758598493947 2208 914281
SGTC_492 tmb-8 126 µM 0.0818567290025051 0.411180622019009 no 1320 0.467380322082773 2264 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_715 0868-0130 184 µM 0.081331063795872 0.411409437813403 no 1321 0.467589335238114 2265 2876258
SGTC_2268 7933382 153.85 µM 0.0800960967281976 0.411947122685019 no 1322 0.468080413567553 2276 935025 YOR257W CDC31
SGTC_2233 sulbentine 40.3845 µM 0.0800769980736015 0.411955439234139 no 1323 0.468088008433091 2234 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3033 9090887 49.47 µM 0.0793951315222364 0.41225238533309 no 1324 0.468359170450849 2210 19325384
SGTC_3230 9131665 49.47 µM 0.0786373219217927 0.412582462814763 no 1325 0.46866055042111 2221 15943720
SGTC_2695 st077686 51.995 µM 0.0785246821734563 0.412631530349058 no 1326 0.468705348651459 2188 2876092
SGTC_2139 5578692 56.4705 µM 0.0783770266302777 0.412695853347427 no 1327 0.468764073699452 2282 650991 YMR113W FOL3
SGTC_16 erodoxin 22.806 µM 0.0780432597421401 0.41284126043349 no 1328 0.468896820805322 2248 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3073 9114972 49.47 µM 0.0775144415863093 0.41307166698357 no 1329 0.469107151557567 2285 41905075
SGTC_1946 st076057 65.1 µM 0.0764939354801808 0.413516387008679 no 1330 0.469513069313234 2280 953009
SGTC_2170 morpholine 200 µM 0.0764488139809683 0.41353605279271 no 1331 0.469531017630502 2229 121171 Reacts with secondary amines.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0757353103321297 0.413847055495161 no 1332 0.469814841536244 2254 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2569 tetrandrine 100 µM 0.0750607429440353 0.414141136325547 no 1333 0.470083191132911 2134 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_316 k060-0003 58.6 µM 0.0743316948726483 0.414459022399869 no 1334 0.470373228960256 2253 6152314
SGTC_2484 5809818 12.04 µM 0.0738423794143649 0.414672409551204 no 1335 0.470567902578325 2219 2870548
SGTC_870 0573-2213 57.6 µM 0.0735779649770284 0.414787729377869 no 1336 0.470673102502527 2280 3916321
SGTC_627 1391-0720 175 µM 0.0724265286303955 0.415289994108165 no 1337 0.471131236717469 2209 997839
SGTC_3313 9133968 57.047 µM 0.0723508952592457 0.415322990778059 no 1338 0.471161331114427 2288 1494643
SGTC_2765 myclobutanil 7.74 µM 0.0700809158796439 0.416313594578045 no 1339 0.472064628136237 2207 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1940 st075990 51.1 µM 0.0698155032105245 0.416429453735052 no 1340 0.472170253755084 2213 1084979
SGTC_2098 5376439 882.5 nM 0.0692259504347211 0.416686833983449 no 1341 0.47240488359641 2241 2844116
SGTC_2926 9010726 65.15 µM 0.0683453763628998 0.417071331488217 no 1342 0.472755351717622 2194 2994293
SGTC_131 0141-0277 33.849 µM 0.0682698388829618 0.417104318185445 no 1343 0.472785416589953 2266 1547771
SGTC_3183 9108214 49.47 µM 0.0681376741477748 0.417162035018584 no 1344 0.472838020198881 2272 4974831
SGTC_3025 9087895 49.47 µM 0.0681326798980484 0.417164216061092 no 1345 0.472840007996818 2285 17173641
SGTC_3107 9121808 49.47 µM 0.0681239099194455 0.417168046011129 no 1346 0.472843498601914 2284 662681
SGTC_2848 9016370 25.97 µM 0.0679540008312202 0.417242248805575 no 1347 0.47291112580636 2281 7894410
SGTC_1559 coumarin 343 70.1 µM 0.0675264049678718 0.417429001753872 no 1348 0.473081320935394 2257 108770 A hepatotoxic, DNA x-linker.
SGTC_1048 3161-0300 24.5 µM 0.0669294758500287 0.417689742325829 no 1349 0.473318923654101 2279 2165101
SGTC_2658 polymyxin b sulfate 77.05 µM 0.065352606058572 0.418378697943212 no 1350 0.473946629125146 2235 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2163 5671233 125 µM 0.0652987633736183 0.418402226970729 no 1351 0.473968063464901 2286 701023
SGTC_291 SEC14.278 35.5 µM 0.0646025360061551 0.41870650167879 no 1352 0.474245232744609 2283 1068044
SGTC_2308 7584454 197.62 µM 0.0645001003844657 0.418751273589861 no 1353 0.474286013592232 2264 893577
SGTC_1375 2910-0797 186 µM 0.0644100414278537 0.418790636856132 no 1354 0.474321867363874 2238 742508
SGTC_1311 1190-0148 100 µM 0.0642654384814272 0.418853842090366 no 1355 0.474379436320759 2277 1961333
SGTC_1705 st027868 56.3335 µM 0.0642319089686299 0.418868497974145 no 1356 0.474392785081481 2288 292948
SGTC_1011 4112-3381 17.4 µM 0.0641433491604066 0.418907208360947 no 1357 0.474428042626996 2215 2877139
SGTC_2014 4013930 200 µM 0.0638194812282715 0.419048780988951 no 1358 0.474556983050905 2313 64556
SGTC_836 0330-0104 1.35 µM 0.0635014038461945 0.419187832592886 no 1359 0.474683620697208 2300 46494820
SGTC_1867 st057372 64 µM 0.0626695353494741 0.419551542245662 no 1360 0.475014828480112 2290 688837
SGTC_244 nsc-207895 1.295 µM 0.062152795771285 0.419777505823422 no 1361 0.475220576642717 2280 42640
SGTC_3050 9093513 49.47 µM 0.0619695198996622 0.419857656365666 no 1362 0.475293552464998 2281 25236664
SGTC_2200 6600604 21.907 µM 0.0613268657734436 0.420138729297919 no 1363 0.475549447636163 2280 2904777
SGTC_919 tnp00227 403.569 nM 0.0604108678444948 0.420539422983687 no 1364 0.475914201589632 2251 1269246 A methoxyflavone. YNL221C POP1
SGTC_2856 9022925 19.48 µM 0.0597334098378166 0.420835822881538 no 1365 0.476183981015766 2227 4944862
SGTC_1698 5-fluorocytosine 1.055 µM 0.0596709645502203 0.420863146064504 no 1366 0.47620884872306 2300 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1393 3470-5649 58.2 µM 0.0588501331045401 0.421222339506463 no 1367 0.47653573859045 2238 4108395
SGTC_2024 5144227 134 µM 0.0587011620699475 0.421287535835068 no 1368 0.476595066869048 2280 3475211
SGTC_2917 7979103 53.79 µM 0.0584905606035408 0.421379708054521 no 1369 0.476678940585339 2268 2980565
SGTC_2540 epiandrosterone 100 µM 0.0584811857626776 0.421383811164562 no 1370 0.476682674214646 2323 441302 A steroid.
SGTC_2231 micatex 6.853 µM 0.0573091034705638 0.421896866465217 no 1371 0.477149484376169 2240 20737 An antifungal of unknown mechanism.
SGTC_1236 0330-0013 258 µM 0.0572216877978329 0.421935136230454 no 1372 0.477184301049549 2248 4617066
SGTC_3295 9122362 53.5725 µM 0.0569689806813486 0.422045773190972 no 1373 0.47728495241329 2225 4730473
SGTC_251 melphalan 456.522 µM 0.0568526792888303 0.422096692829833 no 1374 0.477331274879647 2240 460612 A DNA alkylator.
SGTC_2531 methyl deoxycholate 70.07 µM 0.0563952565151093 0.422296976509057 no 1375 0.477513467848005 2260 16667744 Haematoxylin.
SGTC_2192 5915882 198.485 µM 0.0559761455289705 0.422480502919864 no 1376 0.477680405234548 2285 2876149
SGTC_1866 st057638 64 µM 0.0551672944772092 0.422834741925511 no 1377 0.478002592233053 2260 688802
SGTC_568 1193-0097 7.48 µM 0.0546791903196032 0.423048538973826 no 1378 0.478197024137564 2298 3646150
SGTC_247 mechlorethamine 29.705 µM 0.0543990954660576 0.423171235020316 no 1379 0.4783085997515 2285 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2903 5923464 63.88 µM 0.0526807738712204 0.423924111485098 no 1380 0.478993128989532 2316 2876576
SGTC_1726 st035556 14.5795 µM 0.0512858386729292 0.424535501755426 no 1381 0.479548876178203 2287 5919439
SGTC_2142 5622915 118.518 µM 0.050334028765122 0.424952777662707 no 1382 0.479928103546912 2274 5322196
SGTC_49 0717-0965 32.132 µM 0.0503103593407357 0.42496315547275 no 1383 0.479937534332591 2276 5889349 YGL099W LSG1
SGTC_2421 5690543 90.72 µM 0.0479590439754117 0.425994342847544 no 1384 0.480874441598328 2246 3397993
SGTC_2293 7624732 200 µM 0.047864181931196 0.42603595599551 no 1385 0.480912242667043 2314 894453
SGTC_2161 5662504 8.5105 µM 0.0474637016797322 0.426211643803799 no 1386 0.481071829788645 2271 2859334
SGTC_2356 9061756 188.97 µM 0.0472322610589144 0.426313181820557 no 1387 0.481164057799702 2312 20104043
SGTC_2226 7298446 200 µM 0.0466433628125006 0.426571566257331 no 1388 0.481398735547122 2331 3283010
SGTC_1350 1495-0454 146 µM 0.045697761327283 0.426986523357524 no 1389 0.481775574074566 2310 1069057
SGTC_182 3448-4371 550.524 µM 0.045342406940662 0.427142483987109 no 1390 0.481917193164235 2312 3491403
SGTC_2435 5706476 10.6 µM 0.0450943165969561 0.427251374512082 no 1391 0.482016065757349 2315 5725375
SGTC_900 1112-0045 141 µM 0.0450510584967881 0.427270361700438 no 1392 0.482033305721677 2329 56211 YIL048W NEO1
SGTC_2081 5214970 32.255 µM 0.0450258501483412 0.427281426426335 no 1393 0.482043352203068 2318 2063512
SGTC_274 sirtinol 40.1 µM 0.0449654679871928 0.427307930262046 no 1394 0.482067416827063 2262 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3192 9110362 49.47 µM 0.0445521087984506 0.427489376826376 no 1395 0.482232158183371 2333 16649480
SGTC_2208 7283366 200 µM 0.0437758557307649 0.427830159314694 no 1396 0.482541536482848 2320 898663
SGTC_813 k007-0158 173 µM 0.041633598442777 0.428770909244091 no 1397 0.483395394384671 2310 6523916
SGTC_600 1495-0418 41.6 µM 0.0412528239319949 0.428938164921918 no 1398 0.483547171038204 2310 5377768
SGTC_1630 st005209 31.3 µM 0.0412496227698289 0.428939571090518 no 1399 0.483548447031021 2336 3367314
SGTC_2182 6325192 200 µM 0.0402801375388781 0.42936547649709 no 1400 0.48393489443691 2331 736248
SGTC_575 k072-0246 11.9 µM 0.0402475119807335 0.429379810692683 no 1401 0.483947899605371 2329 6796779
SGTC_192 3455-0609 60.9 µM 0.0395550132337827 0.429684085275955 no 1402 0.484223946792806 2285 3769639
SGTC_206 4546-0025 72.014 µM 0.0372406058129659 0.430701306701392 no 1403 0.485146581148255 2294 6620745 YIL048W NEO1
SGTC_2336 9001819 198.65 µM 0.0372077386471847 0.430715755708025 no 1404 0.485159684169148 2317 2989602
SGTC_415 dibenzyl ketone 100 µM 0.0369813792079114 0.430815269971636 no 1405 0.48524992641154 2322 7593
SGTC_2815 7968870 71.43 µM 0.0366094231368045 0.430978802332097 no 1406 0.485398214995845 2333 2977326 YHR190W ERG9
SGTC_3291 9121177 71.43 µM 0.0360252496487307 0.431235661027362 no 1407 0.485631112855172 2309 17015612
SGTC_582 0987-0078 156 µM 0.0353920974453492 0.431514088304976 no 1408 0.485883543045452 2345 1625765
SGTC_1079 idarubicin 2.36 µM 0.0338747527278934 0.432181475522658 no 1409 0.486488513017451 2351 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1191 1487-1166 10.6 µM 0.0325013469401724 0.432785719755582 no 1410 0.487036120947787 2317 3955771
SGTC_2253 7938677 135.83 µM 0.0324018814882066 0.43282948674251 no 1411 0.487075781033338 2342 2301972
SGTC_405 ebelactone b 50 µM 0.0308890338158164 0.43349527427181 no 1412 0.487679017749352 2301 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_344 k064-0035 6.43 µM 0.0306913550860632 0.433582284479095 no 1413 0.487757842779116 2314 5088750
SGTC_835 0312-0010 67.2 µM 0.029539106238097 0.434089521901074 no 1414 0.488217315135489 2352 1626196
SGTC_432 NS 1619 61.3 µM 0.0293904517940211 0.434154969765085 no 1415 0.488276593940625 2248 4552 A K+/calcium channel activator.
SGTC_1706 st031321 9.9705 µM 0.0286586547744974 0.434477183195596 no 1416 0.488568415761031 2348 6103185
SGTC_2150 5556613 200 µM 0.0285032605093671 0.434545609580952 no 1417 0.488630383788345 2332 743190
SGTC_723 4182-0001 115 µM 0.0284130859733665 0.434585317978658 no 1418 0.488666343659043 2309 744821 YLR208W SEC13
SGTC_1228 0124-0032 52.5 µM 0.0265732576470222 0.435395630742712 no 1419 0.489400051515724 2334 X1228
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0260725088785309 0.435616221873573 no 1420 0.489599752171551 2356 390807
SGTC_780 0109-0199 192 µM 0.0250396249653567 0.436071293748517 no 1421 0.490011678677805 2358 610414
SGTC_1331 1472-0049 76.2 µM 0.0249800550815003 0.43609754185914 no 1422 0.490035436191879 2365 24051409
SGTC_381 3461-2219 42.7 µM 0.0249337222742715 0.436117957548451 no 1423 0.490053914552166 2364 2883159
SGTC_2433 5607874 27.82 µM 0.0229489974524854 0.436992648713039 no 1424 0.490845478178477 2367 2252428
SGTC_189 3970-0742 2.116 µM 0.0217998793907945 0.43749921943149 no 1425 0.491303795198589 2373 2891807
SGTC_491 tetrandrine 80.3 µM 0.0210168674240838 0.437844456756127 no 1426 0.491616100194421 2354 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1794 st048918 76.9 µM 0.0208135851147485 0.437934093581608 no 1427 0.491697180366267 2362 672303
SGTC_842 0271-0008 11.1 µM 0.0203940501288372 0.438119096547392 no 1428 0.491864515087016 2351 1221709
SGTC_1782 st039423 80.636 µM 0.0177300289042528 0.439294167910089 no 1429 0.492927112404291 2355 2068169
SGTC_446 go6976 132 µM 0.0172921498707299 0.439487363167134 no 1430 0.493101774082041 2361 3501 A protein kinase C inhibitor.
SGTC_3082 9117008 49.47 µM 0.0167118671526999 0.439743410113267 no 1431 0.493333239932466 2367 41448529
SGTC_1872 amphotericin b 148 nM 0.016670332270337 0.439761738147405 no 1432 0.493349807645167 2370 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_328 k915-0120 63.5 µM 0.0149222794683652 0.440533215313084 no 1433 0.494047092727623 2369 6624543
SGTC_2885 9057732 51.95 µM 0.0146027886268028 0.440674242345307 no 1434 0.494174537244079 2351 6471414
SGTC_1757 st041620 31.8375 µM 0.0146007110335423 0.440675159444164 no 1435 0.494175365995518 2356 5289815
SGTC_1326 1431-2094 10.8 µM 0.0144829430311631 0.440727145548893 no 1436 0.494222343663596 2379 616278
SGTC_1500 4488-1866 171 µM 0.0144352864641443 0.440748182786781 no 1437 0.494241353895816 2372 2900003
SGTC_3334 9142812 21.919 µM 0.0143564164952068 0.440782999054698 no 1438 0.494272815200873 2345 45283678
SGTC_2248 tofa 1.1 µM 0.0142303584478492 0.440838646923768 no 1439 0.494323099948843 2379 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_85 0868-0259 160.055 µM 0.0130968998829153 0.441339060455792 no 1440 0.494775242261007 2344 83173
SGTC_219 mitoxanthrone 164.414 µM 0.013035826499571 0.44136602656704 no 1441 0.494799604936019 2359 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3077 9117319 49.47 µM 0.00999977200465497 0.442706894703317 no 1442 0.496010734637804 2387 17154678
SGTC_46 0329-0187a 2.197 µM 0.00986830707178369 0.442764970899817 no 1443 0.496063178970076 2361 46494817
SGTC_1820 st053765 18.6 µM 0.00867029818408675 0.443294262078154 no 1444 0.496541094807398 2377 3690829
SGTC_3 0833-0587 95.581 µM 0.00840124806261646 0.443413144807488 no 1445 0.496648426365947 2324 5382644
SGTC_622 1348-1566 26.3 µM 0.00835338959245832 0.443434292128173 no 1446 0.496667518463218 2377 7340407
SGTC_420 mitomycin C 81.9 mM 0.00726346825037656 0.443915941410038 no 1447 0.497102320891872 2394 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1105 epirubicin 18.1 µM 0.00541549417110963 0.444732772227293 no 1448 0.497839540966053 2400 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2568 diosmetin 100 µM 0.00538021726349012 0.444748367416433 no 1449 0.497853614210998 2398 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_159 3970-0959 50 µM 0.00471277374583823 0.445043446441494 no 1450 0.498119882254465 2390 6615653
SGTC_3214 9129694 49.47 µM 0.00451457939355339 0.445131074703146 no 1451 0.498198949519681 2394 17158655
SGTC_1680 diphenhydramine 100 µM 0.00374713115820166 0.445470414139504 no 1452 0.498505114449064 2387 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1958 st076513 41.9 µM 0.00229142412746336 0.446114187712246 no 1453 0.499085854833195 2400 732122 YGL099W LSG1
SGTC_1619 st003326 88.7 µM 0.000913354845787581 0.446723757618531 no 1454 0.499635624185667 2398 2849032
SGTC_103 0844-0104 51.839 µM 0.000691485855118208 0.446821910105383 no 1455 0.499724137078078 2404 5375804
SGTC_2451 5856223 45.7 µM -0.00184207925528869 0.447942961953697 no 1456 0.499265117116823 2409 2179896
SGTC_3347 9188721 44.724 µM -0.00217252060510024 0.448089206488133 no 1457 0.499133290357372 2409 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_185 k048-0037 25.491 µM -0.00275622573966637 0.448347556051382 no 1458 0.49890042641032 2412 6827589
SGTC_965 1291-5240 308 µM -0.00367320571852054 0.448753458214989 no 1459 0.49853460622956 2414 2834598
SGTC_295 k015-0027 31 µM -0.00430598097113802 0.449033588162483 no 1460 0.498282167440535 2425 3887424
SGTC_1631 benzylvanillin 81.9 µM -0.0046987745822791 0.449207490897167 no 1461 0.498125467050863 2421 75506
SGTC_2616 abietic acid 100 µM -0.00474702314449442 0.449228852806428 no 1462 0.498106218874103 2412 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_151 3013-0144 2.285 µM -0.00567305789164194 0.449638880417118 no 1463 0.49773678948757 2417 906558 YHR107C CDC12
SGTC_747 3448-8087 38.7 µM -0.00687316810643417 0.45017034249816 no 1464 0.497258024230744 2426 5168703
SGTC_645 0845-0943 5.41 µM -0.00704505778731227 0.450246470219209 no 1465 0.497189451830037 2424 1885106
SGTC_3318 9139014 38.6185 µM -0.0071521763368212 0.450293912568293 no 1466 0.497146718788323 2420 16643984
SGTC_2701 st077767 14.721 µM -0.00742868852228385 0.450416381918543 no 1467 0.497036409318383 2431 5721188
SGTC_1812 st052057 4.327 µM -0.00800420568625068 0.450671297975273 no 1468 0.496806818027191 2417 3645418
SGTC_1928 4'-methoxychalcone 40.3 µM -0.00804750661430396 0.450690478248248 no 1469 0.496789544012567 2424 641818
SGTC_2125 5246583 200 µM -0.0082191139386911 0.450766493347535 no 1470 0.496721084859676 2415 835267
SGTC_1970 st070122 35.8 µM -0.00928773649189441 0.451239890415915 no 1471 0.496294782494175 2437 102928
SGTC_666 0272-0154 136 µM -0.0102088041611404 0.451647976726177 no 1472 0.495927347129671 2430 6870312
SGTC_107 0358-0022 2.6945 µM -0.0120614684534967 0.452468968612279 no 1473 0.495188286937673 2462 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3022 9087993 49.47 µM -0.0130953953822283 0.452927232833249 no 1474 0.494775842418473 2430 17173644
SGTC_337 1315-0038 354 µM -0.0146992429454704 0.453638225060855 no 1475 0.494136061667907 2442 1626437
SGTC_1005 4092-0690 4.4 µM -0.0149050229726432 0.453729458999383 no 1476 0.494053976307823 2442 1529343
SGTC_2735 sertaconazole 140 nM -0.0150006849205087 0.45377187218954 no 1477 0.494015816978428 2430 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1137 ixabepilone 100 µM -0.0154510726085801 0.453971565547639 no 1478 0.493836159114615 2436 154225 A novel microtubule stabilizer.
SGTC_471 1-acyl-paf 4 µM -0.0155163608903886 0.454000514100303 no 1479 0.493810115980641 2433 16759367
SGTC_3095 9117207 49.47 µM -0.0157462825619575 0.454102462358023 no 1480 0.493718401710209 2428 17015229
SGTC_2452 5863136 48.41 µM -0.0157795315016384 0.454117205331262 no 1481 0.493705138950188 2438 2184096
SGTC_990 3985-0011 41.3 µM -0.018356622614828 0.45526010880766 no 1482 0.492677178372371 2463 5399565 YGL099W LSG1
SGTC_2835 9006588 71.43 µM -0.0192731983725858 0.455666686984483 no 1483 0.492311582278598 2505 2345538
SGTC_1747 st037496 66.6 µM -0.0210950078155162 0.456474949634817 no 1484 0.49158493359814 2458 723305
SGTC_2215 7188065 200 µM -0.021877011648653 0.456821948333393 no 1485 0.491273031216572 2445 940217
SGTC_110 0850-0284 111.64 µM -0.0218809538960719 0.456823697711168 no 1486 0.491271458863777 2441 3906265
SGTC_1029 k015-0030 64.7 µM -0.0224024179605113 0.45705510547763 no 1487 0.49106347579166 2523 2208316
SGTC_1773 st048542 73.5835 µM -0.0230166596755079 0.457327703439213 no 1488 0.490818491985068 2446 3237138
SGTC_2473 5854593 8.94 µM -0.0231320907827302 0.457378933537611 no 1489 0.490772453893537 2442 2872951
SGTC_2114 5491910 81.25 µM -0.0232782181593672 0.457443788127546 no 1490 0.490714173198308 2483 2849228
SGTC_806 3966-4455 5.86 µM -0.0235715273836878 0.457573968723778 no 1491 0.490597191847593 2458 714982
SGTC_1711 st032263 62.8 µM -0.0236981720182459 0.457630179322053 no 1492 0.490546682057825 2475 3958979
SGTC_1215 3852-0577 11.2 µM -0.0240302685450379 0.457777582754703 no 1493 0.490414232433189 2492 2884876
SGTC_2326 6164455 177.58 µM -0.0242117301237264 0.457858128236919 no 1494 0.490341860794072 2478 2888790
SGTC_3233 9132340 49.47 µM -0.0244721469962518 0.457973722685828 no 1495 0.490238000268181 2460 17682950
SGTC_113 0099-0221 2.5 µM -0.0246932404818785 0.458071864968545 no 1496 0.490149823376085 2445 89219
SGTC_1292 0kpi-0043 232 µM -0.0254574079702717 0.458411094710345 no 1497 0.4898450604913 2462 3333905
SGTC_2504 purpurogallin 52.29 µM -0.0264942945622515 0.458871438490759 no 1498 0.48943154214152 2490 5281571 An antioxidant.
SGTC_799 1310-0557 151 µM -0.0270624157742517 0.459123689183532 no 1499 0.489204975820394 2532 5354492
SGTC_1844 rapamycin 4 nM -0.027114073862203 0.459146626635655 no 1500 0.489184374784617 2445 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2010 4012422 159 µM -0.0279317510979199 0.459509713353253 no 1501 0.488858292301527 2487 952393
SGTC_1385 3091-4834 14.1 µM -0.0282475672447833 0.459649959467089 no 1502 0.48873234958426 2479 4072814
SGTC_572 0960-0087 17.7 µM -0.0286466265369744 0.459827178974522 no 1503 0.488573212364191 2452 6796365
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.029202323277108 0.460073973391798 no 1504 0.488351614159038 2474 94937 An inhibitor of serotonin biosynthesis.
SGTC_905 2-aminofluorene 215 µM -0.0292252872297421 0.460084172407174 no 1505 0.488342456775909 2460 1539 An established DNA mutagen. YPR165W RHO1
SGTC_221 trifluoperazine 10.304 µM -0.0294621555724655 0.46018937463758 no 1506 0.488248000653994 2437 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1662 st014054 52 µM -0.0294874202571454 0.460200595808547 no 1507 0.488237925880321 2450 2838777
SGTC_2141 5621638 7.665 µM -0.0298805030547346 0.460375185452131 no 1508 0.488081177607285 2504 2856238
SGTC_1018 4259-0013 28.1 µM -0.0300298180926359 0.460441506459112 no 1509 0.488021636245194 2563 6801262
SGTC_3152 9099253 49.47 µM -0.0303092159273761 0.460565609075993 no 1510 0.487910223351759 2490 25236131
SGTC_983 1491-0821 12.2 µM -0.0318474141089763 0.461248912682395 no 1511 0.487296867401956 2480 46495113
SGTC_63 0099-0242 26.702 µM -0.0324477276044368 0.461515617128524 no 1512 0.487057500691392 2469 3898502 YLR359W ADE13
SGTC_913 3487-1245 167 µM -0.0331065191757025 0.461808321853219 no 1513 0.48679482202537 2470 4016153
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0340997580386435 0.462249662408017 no 1514 0.486398800715677 2493 5377381
SGTC_516 3992-2719 87.3 µM -0.0346466313946493 0.462492682634042 no 1515 0.486180758662855 2465 5350887 YDR037W KRS1
SGTC_2197 6588183 93.1375 µM -0.034855609258424 0.462585552165651 no 1516 0.486097438882836 2467 884136
SGTC_1318 1280-3875 124 µM -0.035310652357631 0.462787779864574 no 1517 0.48591601463793 2495 373245
SGTC_156 3474-0145 5.642 µM -0.0359425505524201 0.463068620452676 no 1518 0.485664083668339 2455 2265471
SGTC_2115 tiliquinol 12.7705 µM -0.0361920369186658 0.463179507152793 no 1519 0.485564617724882 2526 71208 A bioactive hydroxyquinoline.
SGTC_717 1532-0246 73.2 µM -0.0366178126191219 0.463368754006084 no 1520 0.485394870319254 2489 9561992
SGTC_974 1326-0144 138 µM -0.0381620526504842 0.464055200060425 no 1521 0.484779238220229 2478 5411856
SGTC_648 0375-0473 33.3 µM -0.038936863955819 0.464399659865775 no 1522 0.484470362828 2478 1713139
SGTC_2091 4-phenylthiadiazole 200 µM -0.0399586017152566 0.464853937137993 no 1523 0.484063065479811 2491 270010
SGTC_2944 9067346 25.62 µM -0.0402038790802568 0.464962997335956 no 1524 0.483965292536684 2494 6473075
SGTC_2760 etidronate 98.04 µM -0.0420759264420126 0.465795471124199 no 1525 0.483219085543837 2507 3305 A chelator and antioxidant.
SGTC_456 gingerol 170 µM -0.0423504391684061 0.465917555840767 no 1526 0.483109668342701 2532 442793 A herb.
SGTC_3051 9093778 49.47 µM -0.0424219125325971 0.465949342891661 no 1527 0.483081180198034 2484 17217378
SGTC_1068 loratadine 26.9 µM -0.0429502382173527 0.466184317084258 no 1528 0.482870600683004 2517 3957 A H1 histamine antagonist.
SGTC_944 3370-0224 231 µM -0.0434664795956529 0.466413928138189 no 1529 0.482664842333804 2490 4580514
SGTC_2793 7325131 81.82 µM -0.0435317627472969 0.466442965223827 no 1530 0.482638822752849 2521 4176441
SGTC_918 glabranin 770.725 nM -0.0435318625240703 0.466443009603358 no 1531 0.482638782985374 2511 124049 Also referred to as licorice root.
SGTC_1573 oleylamine 1.06 µM -0.0438583236862766 0.466588217904883 no 1532 0.482508668096397 2481 5356789 An amine of the fatty acid oleic acid.
SGTC_2634 4'-methoxyflavone 100 µM -0.0442221274776485 0.466750041260935 no 1533 0.482363672064159 2505 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3269 9137823 49.47 µM -0.0445299663455549 0.466886975185702 no 1534 0.482240982985899 2496 17682936
SGTC_2477 5967686 25.23 µM -0.0446960375202327 0.466960849154976 no 1535 0.482174796072192 2502 776118
SGTC_3331 9141060 1.957 µM -0.0448282188056597 0.467019648590496 no 1536 0.482122116171233 2496 4906567 YPR165W RHO1
SGTC_1605 st000082 49.1 µM -0.0461096099553123 0.467589698897264 no 1537 0.481611443259993 2607 1114022
SGTC_3229 9132204 49.47 µM -0.046234149373655 0.467645106100004 no 1538 0.481561812151529 2483 17682924
SGTC_1147 3809-1045 12.3 µM -0.0464568294302893 0.467744177331493 no 1539 0.481473071017048 2497 325925
SGTC_1801 st050089 28.441 µM -0.046586914925447 0.467802053803934 no 1540 0.481421230542135 2477 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_466 geldanamycin 89.2 µM -0.0467250161064989 0.467863497288289 no 1541 0.481366196073633 2498 5288382 HSP90 inhibitor.
SGTC_2697 mebhydrolin 72.4 µM -0.0469043224016885 0.467943274747047 no 1542 0.481294741554687 2508 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1098 clofazimine 15.1 µM -0.0471601451117293 0.468057098331318 no 1543 0.481192795875521 2583 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1674 st016616 23.6 µM -0.0476518379846984 0.468275875308198 no 1544 0.48099685909235 2479 625830
SGTC_1437 4092-1038 11.6 µM -0.0483140979238841 0.468570560619673 no 1545 0.48073295957827 2490 3977136
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0488427216061669 0.468805794272436 no 1546 0.480522317932721 2512 4330530
SGTC_3028 9087778 49.47 µM -0.0490745862126811 0.46890897575873 no 1547 0.480429928131296 2500 17217395
SGTC_1406 3909-7906 11.9 µM -0.0491848917473983 0.468958063281206 no 1548 0.480385975666498 2502 X1406
SGTC_1402 3909-7673 35.9 µM -0.0493026940276948 0.469010487482512 no 1549 0.480339036303535 2492 5328014
SGTC_1400 3771-8998 51.5 µM -0.0495724364623877 0.469130529894982 no 1550 0.480231556066894 2523 670767
SGTC_807 1315-0151 48 µM -0.0505737225901545 0.469576152769753 no 1551 0.479832601178482 2486 4011080
SGTC_1023 4482-3888 16 µM -0.050836560401364 0.469693135202388 no 1552 0.479727878770819 2484 3303168
SGTC_1274 0865-0114 173 µM -0.0516963292065276 0.470075814677463 no 1553 0.47938533109969 2540 870624
SGTC_2212 7123476 200 µM -0.0522324429176408 0.470314450646296 no 1554 0.479171741248605 2501 1085715
SGTC_2950 9072895 21.46 µM -0.05257390765132 0.470466449650247 no 1555 0.479035703444242 2535 17332245
SGTC_1606 st000094 49.2 µM -0.0533970497607427 0.470832879310817 no 1556 0.478707777905565 2488 1242210
SGTC_169 k015-0017 16.025 µM -0.0533989949398043 0.470833745255436 no 1557 0.47870700299695 2519 1840002
SGTC_2285 7945142 200 µM -0.0543117915058511 0.471240114392189 no 1558 0.478343377578702 2560 2970608
SGTC_982 1491-0518 27.5 µM -0.0543514896684743 0.471257788353425 no 1559 0.478327563661179 2540 3091256
SGTC_1590 st077108 57.8 µM -0.0548461284981866 0.471478010523051 no 1560 0.478130525228202 2477 5489485
SGTC_1642 st009582 77.7 µM -0.0558178240337097 0.471910652313745 no 1561 0.47774346777724 2521 6739311
SGTC_2122 5258151 111.688 µM -0.0560621481366012 0.472019441435912 no 1562 0.47764614895093 2537 2173356
SGTC_828 2074-0507 139 µM -0.0564668007129296 0.47219962390255 no 1563 0.477484971251874 2581 X828
SGTC_1809 st050081 57.6 µM -0.0569449099994509 0.472412522279017 no 1564 0.477294539662431 2589 5036894
SGTC_3215 9129942 49.47 µM -0.0571607589347778 0.472508640730669 no 1565 0.477208568429334 2526 17682944
SGTC_423 5-fluorouracil 457 µM -0.0576392099487967 0.472721702707354 no 1566 0.477018008276089 2491 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_447 ml7 120 µM -0.0580682390798673 0.472912762959244 no 1567 0.476847136615193 2515 4216 Selective myosin light chain kinase inhibitor.
SGTC_2193 5925765 200 µM -0.0597864132985503 0.473677982339152 no 1568 0.476162873418167 2561 877370
SGTC_1701 st028638 40.4 µM -0.0598237338123981 0.473694604780375 no 1569 0.476148011289341 2516 3490878
SGTC_1339 1486-1321 22.7 µM -0.0601912343068839 0.473858290803384 no 1570 0.476001663533868 2537 3469382
SGTC_2605 digitonin 300 nM -0.0603407095609322 0.473924868875638 no 1571 0.475942139728274 2517 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1780 st038448 24.544 µM -0.0606765295435738 0.474074449780002 no 1572 0.47580841197169 2686 728868 YDL195W SEC31
SGTC_998 3996-0085 177 µM -0.0608867791804181 0.474168101014879 no 1573 0.475724689298114 2556 715391
SGTC_2390 9097792 176.6 µM -0.0610007710390308 0.474218876864155 no 1574 0.475679297500267 2536 4497149
SGTC_102 gallobenzophenone 83.616 µM -0.0624442600399318 0.47486189189372 no 1575 0.475104524646872 2516 70837
SGTC_2690 usnic acid 100 µM -0.063384794547729 0.47528089670532 no 1576 0.474730047547885 2574 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1447 4239-0816 81.9 µM -0.0637093493866061 0.475425491111557 no 1577 0.474600830069462 2526 1341554
SGTC_1936 st074407 74.3 µM -0.0647888744409946 0.475906460084322 no 1578 0.474171049874629 2519 809813
SGTC_689 0833-0039 98 µM -0.064806634920027 0.475914373340513 no 1579 0.474163979327941 2571 5374726
SGTC_2244 6635614 200 µM -0.0665905081703577 0.4767092334447 no 1580 0.473453851178287 2527 836499
SGTC_1065 prochlorperazine maleate 2.48 µM -0.067343601966716 0.477044825768833 no 1581 0.473154083150861 2529 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_72 0744-0168 198.391 µM -0.067982707174146 0.477329635479774 no 1582 0.472899700054712 2574 677577
SGTC_199 4063-0024 41.6 µM -0.0684779841668725 0.477550357811796 no 1583 0.472702572510082 2620 306215
SGTC_803 4488-1585 147 µM -0.0689790882828565 0.477773684034954 no 1584 0.472503132488712 2523 747204
SGTC_1382 3002-2117 298 µM -0.0694878243138335 0.478000418700401 no 1585 0.472300662008504 2527 1497314
SGTC_636 0kpi-0074 126 µM -0.0695529760957649 0.478029456215013 no 1586 0.472274732942526 2585 616434
SGTC_17 0960-0276 49.807 µM -0.0713776417038547 0.478842738715352 no 1587 0.471548601775265 2532 6821114
SGTC_3127 9126946 49.47 µM -0.0718520869205128 0.479054221067857 no 1588 0.47135981026808 2616 27243249
SGTC_1635 st007035 42.4 µM -0.0723584783431012 0.479279949838296 no 1589 0.471158313810105 2524 3716403
SGTC_1985 st071382 65.5 µM -0.073642604177157 0.47985239071285 no 1590 0.470647384962009 2542 6123237
SGTC_628 1636-0253 16 µM -0.0743866922686047 0.480184111283425 no 1591 0.470351348748409 2582 4456143
SGTC_1854 st056233 32.9 µM -0.0746647784509447 0.480308087918191 no 1592 0.470240716071685 2535 5393174
SGTC_3202 9113761 49.47 µM -0.0752575462041585 0.480572362519771 no 1593 0.470004899435102 2685 4798415
SGTC_1555 citronellol 128 µM -0.075483473639301 0.480673090365669 no 1594 0.469915023072944 2542 8842 A terpine precursor.
SGTC_1556 plumbagin 1.48 µM -0.0756312846323731 0.480738991321359 no 1595 0.469856223100228 2535 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1976 st070609 63.5 µM -0.0758921633192268 0.48085530435135 no 1596 0.46975244582249 2509 682556
SGTC_884 0851-0618 334 µM -0.0761254842706741 0.480959332117778 no 1597 0.469659632724345 2561 9642473
SGTC_730 1436-0052 41.2 µM -0.0761550060671248 0.480972494708289 no 1598 0.469647889321164 2543 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2565 isoliquiritigenin 100 µM -0.0767883597591146 0.481254886808702 no 1599 0.469395955481443 2665 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3108 9121785 49.47 µM -0.0772240312730221 0.481449144234613 no 1600 0.46922266226842 2507 17140271
SGTC_964 1287-0107 19.4 µM -0.0774388336770053 0.481544922058812 no 1601 0.469137224355801 2603 51516812 YPR165W RHO1
SGTC_2521 angolensin 13.4 µM -0.077696093085987 0.481659632355417 no 1602 0.469034900989378 2635 821428 A flavenoid.
SGTC_967 1306-0166 352 µM -0.0781108530691029 0.481844574326722 no 1603 0.468869937036423 2558 4437607
SGTC_753 1322-0200 289 µM -0.0792517875644407 0.482353338416811 no 1604 0.468416176785834 2644 5403907
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0793258670032461 0.482386372830437 no 1605 0.468386716116753 2632 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2311 7694451 200 µM -0.0801582013940328 0.482757545868833 no 1606 0.468055716799008 2602 2163142
SGTC_2008 4012253 172 µM -0.0809539215008958 0.483112405030054 no 1607 0.467739298743241 2571 603940
SGTC_282 k297-0036 65.7 µM -0.0813832267203265 0.48330386346369 no 1608 0.467568593998771 2642 5061378
SGTC_3064 1327-0027 10 µM -0.0826844864987379 0.483884213216996 no 1609 0.46705121030454 2558 16000455 YPR107C YTH1
SGTC_1162 k048-0130 20.1 µM -0.0829304679538393 0.483993922531671 no 1610 0.466953413776825 2551 6797406
SGTC_1716 st033144 30.6155 µM -0.0835352562813942 0.484263667159657 no 1611 0.466712972443865 2579 674617
SGTC_1708 st033234 31.827 µM -0.083601961192523 0.484293418989626 no 1612 0.466686453795676 2641 674664
SGTC_1925 st057770 10.1 µM -0.0837354404978683 0.484352953902918 no 1613 0.466633389320339 2557 5989122
SGTC_2628 lathosterol 100 µM -0.0860772826171727 0.485397526189139 no 1614 0.465702491215822 2649 6710616
SGTC_1996 st072960 66.8 µM -0.0873355046086714 0.485958794515186 no 1615 0.465202416615716 2533 1719405
SGTC_1323 1348-1351 11.2 µM -0.0878368920462956 0.486182461499346 no 1616 0.465003157729272 2575 6989654
SGTC_669 0108-0021 26.2 µM -0.0893416944018903 0.486853773791022 no 1617 0.464405179597033 2534 17201
SGTC_3045 9092950 49.47 µM -0.0895498143029525 0.486946621814983 no 1618 0.464322483239679 2569 44120432
SGTC_1390 3413-2614 145 µM -0.0904265169422988 0.487337750734619 no 1619 0.463974142767717 2588 3421432
SGTC_455 paf C-16 10 µM -0.0905167605092534 0.487378012368378 no 1620 0.463938287832442 2568 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1975 st070967 30.8 µM -0.09052121344874 0.487379999024333 no 1621 0.463936518629624 2584 261391
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0906412191948963 0.487433539085979 no 1622 0.463888839268944 2577 16623 A steroid.
SGTC_956 1185-0240 191 µM -0.0928608511725541 0.488423858428978 no 1623 0.463007053774979 2617 1416193
SGTC_313 3474-0040 5.03 µM -0.0939130485714879 0.488893336085987 no 1624 0.462589114194766 2555 1043375 YIL048W NEO1
SGTC_1506 4226-2149 212 µM -0.0940715467844969 0.488964057406805 no 1625 0.462526161251903 2657 991114
SGTC_1163 k060-0048 49.9 µM -0.0961513983478663 0.489892110858435 no 1626 0.461700165196092 2565 6809982
SGTC_2627 acetyl isogambogic acid 100 µM -0.0964335343909782 0.490018007500536 no 1627 0.461588129815342 2665 6857789 A caspase activator and apoptosis inducer.
SGTC_1945 st075991 56.6 µM -0.0964873599820016 0.490042026031007 no 1628 0.461566756179738 2615 1084980
SGTC_439 amiodarone 34.4 µM -0.0970823046420874 0.49030750987616 no 1629 0.461330516662653 2658 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2348 9022543 33.42 µM -0.0977384250266407 0.490600297312978 no 1630 0.461070001427284 2673 3162678 YDL140C RPO21
SGTC_989 1501-0895 10.3 µM -0.0988122910132495 0.491079510579586 no 1631 0.460643654719284 2557 2830112
SGTC_3339 9145883 14.936 µM -0.0988262534612837 0.491085741415727 no 1632 0.460638111639383 2624 2030670
SGTC_785 1270-0111 65.3 µM -0.0995367531882185 0.491402809525521 no 1633 0.46035605397776 2571 6741994
SGTC_643 k048-0106 28.4 µM -0.099566804834133 0.491416220515397 no 1634 0.460344124366859 2692 6763920
SGTC_1368 1852-0141 284 µM -0.0999630098380423 0.49159303373899 no 1635 0.460186846089145 2672 2838987
SGTC_3169 9102970 49.47 µM -0.100243349987456 0.491718141300027 no 1636 0.460075565501827 2565 17027839
SGTC_1523 st012844 44.7 µM -0.100313285432468 0.491749351559077 no 1637 0.460047805222479 2712 4274103
SGTC_2769 toremifene 3.73 µM -0.100883494842439 0.492003822150116 no 1638 0.459821472732074 2701 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3338 9144300 39.5675 µM -0.101091832933935 0.492096799190351 no 1639 0.459738780604008 2635 4901274
SGTC_1150 3909-7983 10.9 µM -0.102352475386636 0.492659407178982 no 1640 0.459238452317477 2623 23965914
SGTC_3109 9122853 49.47 µM -0.102492158808185 0.492721746954456 no 1641 0.459183018219693 2653 1234709
SGTC_793 0488-0545 106 µM -0.102740564758272 0.492832609304391 no 1642 0.459084438978012 2585 292548
SGTC_425 3825-7017 13.1 µM -0.103086030137074 0.492986789716974 no 1643 0.45894734614349 2829 3397440
SGTC_2506 ethyl hematommate 54.16 µM -0.10325753516049 0.493063332409345 no 1644 0.458879288719827 2657 3940691 An allergen.
SGTC_1269 0831-0796 3.05 µM -0.103573323176232 0.49320426926756 no 1645 0.458753979399979 2653 927758
SGTC_3335 9143315 29.6265 µM -0.104237372032503 0.493500638420643 no 1646 0.458490488452235 2651 4899691
SGTC_1862 st057513 3.81 µM -0.105071041633355 0.493872715431163 no 1647 0.458159718756983 2616 5393163
SGTC_2846 9008642 19.48 µM -0.105084338157334 0.493878649877627 no 1648 0.458154443415294 2719 2992898
SGTC_1742 st038235 28.8875 µM -0.105093348079264 0.493882671147371 no 1649 0.458150868769684 2704 564103 YBR002C RER2
SGTC_2420 aureobasidin a 50 nM -0.105683974840023 0.494146278488963 no 1650 0.457916547681419 2878 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1441 4106-0040 13 µM -0.105737156952247 0.494170014748915 no 1651 0.457895449302518 2588 2904180
SGTC_1020 4335-0961 93.3 µM -0.106456177152646 0.494490930101677 no 1652 0.457610211665603 2577 669075
SGTC_175 3793-3120 23.7 µM -0.106576204206673 0.494544501306056 no 1653 0.457562598667928 2624 5322297
SGTC_262 fenpropimorph 62.5 µM -0.107685843633141 0.495039766853692 no 1654 0.457122449675632 2595 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1850 st056238 17 µM -0.107788828316934 0.495085732423962 no 1655 0.457081602483792 2572 5393177
SGTC_1219 1469-0211 33.1 µM -0.109097629029706 0.495669900213426 no 1656 0.456562527713021 2607 6822282
SGTC_294 k038-0071 157 µM -0.109631915423539 0.495908375395039 no 1657 0.456350649182425 2650 24152826
SGTC_1305 1181-0477 144 µM -0.10970937130305 0.495942947435539 no 1658 0.456319934029324 2717 6252086
SGTC_951 1171-0579 82.7 µM -0.109858351264446 0.496009443974076 no 1659 0.456260856713283 2576 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3308 9128332 17.569 µM -0.11085705592328 0.496455214097947 no 1660 0.45586485002033 2709 17332805 YDL196W YDL196W
SGTC_73 0327-0325 16.231 µM -0.11209975532122 0.497009896975033 no 1661 0.455372155714641 2773 53298
SGTC_348 k064-0012 10.7 µM -0.112496527581365 0.497186998819458 no 1662 0.455214861427984 2572 5066323
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.113666276306476 0.497709126763815 no 1663 0.454751173411115 2705 23847180
SGTC_1735 st034310 56.75 µM -0.113762375390971 0.49775202164768 no 1664 0.454713082496893 2825 871153
SGTC_1050 3232-1156 69.3 µM -0.114979540822192 0.498295318914228 no 1665 0.454230669269398 2651 700529
SGTC_3349 9149703 23.001 µM -0.114986661656586 0.498298497399486 no 1666 0.454227847184834 2585 4910494
SGTC_2481 5478948 45.16 µM -0.115191581375291 0.498389966262942 no 1667 0.454146635673811 2729 77792
SGTC_2316 5844804 197.44 µM -0.115467054613004 0.498512927836754 no 1668 0.454037466195569 2708 776813
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.115900417776231 0.498706366206839 no 1669 0.453865732295485 2690 5379071
SGTC_2965 9082772 38.63 µM -0.116257970165772 0.498865965493126 no 1670 0.453724047311945 2674 16459634
SGTC_2682 pyrogallin 40.03 µM -0.116458711634867 0.498955569772562 no 1671 0.453644503362658 2639 822798 An ATP competetive kinase inhibitor.
SGTC_1172 0370-0043 85 µM -0.1166352114454 0.499034353429885 no 1672 0.453574566723916 2750 376585
SGTC_2598 perillyl alcohol 100 µM -0.11742460069323 0.499386711007315 no 1673 0.453261795195082 2737 10819 An apoptosis inducer.
SGTC_2472 5377652 49.4 µM -0.117510389875618 0.499425004530054 no 1674 0.453227805578633 2656 1610903
SGTC_520 3584-0023 682 µM -0.118046726656209 0.499664408068276 no 1675 0.453015317083502 2709 1340790
SGTC_3121 9125696 49.47 µM -0.118351901302125 0.499800628302559 no 1676 0.452894417520104 2575 1235365
SGTC_948 3448-0295 75.3 µM -0.11849582099133 0.499864869473316 no 1677 0.452837403067472 2623 678569
SGTC_1122 capsaicin 818.572 nM -0.118580829071031 0.499902814377493 no 1678 0.452803727178971 2747 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1977 st070720 65.3 µM -0.119016279524861 0.499902814377493 no 1679 0.452631229128964 2722 682188
SGTC_334 1502-1024 68.5 µM -0.119039626553129 0.499892393006227 no 1680 0.452621980758713 2710 3296216
SGTC_1938 st074717 56.4 µM -0.119109207627445 0.499861334226954 no 1681 0.45259441802265 2583 17250979
SGTC_61 0978-8327 98.565 µM -0.120083959149544 0.49942623631347 no 1682 0.452208319589243 2624 6150059 YHR072W ERG7
SGTC_1567 st069303 68.4 µM -0.120142973133665 0.499399894374535 no 1683 0.452184945636327 2709 5581319
SGTC_655 k060-0012 42 µM -0.12017517598273 0.499385520062556 no 1684 0.452172190968687 2636 5994525
SGTC_1487 3970-0795 2.82 µM -0.120751895193918 0.499128091382058 no 1685 0.451943776634769 2687 3765103
SGTC_1433 4060-0023 7.6 µM -0.121252655339987 0.498904568646001 no 1686 0.451745459405369 2729 3840627
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.121446246454447 0.498818156075649 no 1687 0.451668794281389 2721 6708760
SGTC_1645 Cervolide 78 µM -0.121512492058422 0.498788586275896 no 1688 0.451642560394819 2687 23173 A fragrance.
SGTC_1013 4112-3890 241 µM -0.122107287838245 0.498523089850252 no 1689 0.45140702510636 2616 705171
SGTC_533 1222-0222 6.71 µM -0.123202647682651 0.498034160600863 no 1690 0.450973314498167 2803 3982874
SGTC_489 paxilline 115 µM -0.123504171718307 0.497899571600193 no 1691 0.450853935515074 2680 105008 A toxic potassium channel blocker.
SGTC_2108 5365811 200 µM -0.124254293268941 0.497564746593627 no 1692 0.45055696772782 2711 780283
SGTC_3013 9080133 71.4286 µM -0.125188841820053 0.497147602993363 no 1693 0.45018702534333 2781 17050193
SGTC_888 0916-0002 6.97 µM -0.125218466910446 0.49713437963387 no 1694 0.450175298914838 2792 2802138 YIL048W NEO1
SGTC_1042 0350-0096 82 µM -0.125317497195135 0.497090176819357 no 1695 0.45013610031052 2602 3122515
SGTC_2761 levamisole 97.89 µM -0.125693530716692 0.496922332130445 no 1696 0.449987261496324 2682 26879 An alkaline phosphatase inhibitor.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.12603070340096 0.496771833658406 no 1697 0.449853810273201 2635 688669
SGTC_1914 st062367 72.6 µM -0.126847326984924 0.496407332169288 no 1698 0.449530618366133 2664 978205
SGTC_258 haloperidol 50.781 µM -0.127002980104145 0.496337856434631 no 1699 0.44946901993478 2650 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1086 cerivastatin 2.18 µM -0.127806588267347 0.495979167925769 no 1700 0.449151018071547 2628 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1244 0416-0015 52.5 µM -0.128419716276837 0.495705501931421 no 1701 0.448908414504394 2656 96201
SGTC_1380 2291-0730 164 µM -0.128543101430515 0.495650429951319 no 1702 0.44885959555603 2711 2999191
SGTC_2878 9043973 25.97 µM -0.128952361711133 0.495467760485688 no 1703 0.448697671925548 2802 6465167
SGTC_3245 9134821 49.47 µM -0.131240888834808 0.49444631658683 no 1704 0.44779237553043 2630 17014901
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.131567068434822 0.494300734858336 no 1705 0.447663367312193 2652 65057 A dermal irritant. YDR527W RBA50
SGTC_1740 st038286 13.222 µM -0.131788105344053 0.494202081248622 no 1706 0.447575947523785 2815 716786
SGTC_2347 9049783 174.81 µM -0.133438023868374 0.49346569811763 no 1707 0.446923487788194 2749 6467988 YPL169C MEX67
SGTC_607 4491-0986 66.8 µM -0.134011566990301 0.493209722395542 no 1708 0.446696713903714 2738 698981 YDR232W HEM1
SGTC_25 0118-0223 35.662 µM -0.134749824057789 0.492880237986105 no 1709 0.446404839246875 2699 5333628
SGTC_3263 9137018 49.47 µM -0.134982388174686 0.492776445527924 no 1710 0.446312899541127 2665 43844957
SGTC_1494 4358-1428 177 µM -0.135898265337269 0.492367697945225 no 1711 0.445950853407332 2749 1564571
SGTC_22 0964-0034 14.468 µM -0.136117487833885 0.492269862126911 no 1712 0.445864201452679 2677 138402
SGTC_2912 7964298 10.93 µM -0.136157132942088 0.492252169140033 no 1713 0.44584853122871 2721 2975850
SGTC_3034 9090421 49.47 µM -0.136772692327231 0.491977456666659 no 1714 0.445605234564559 2622 17173761
SGTC_2724 maprotiline 69.64 µM -0.136966063186442 0.491891159700652 no 1715 0.445528809955884 2670 4011 A tricyclic antidepressant.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.137134597656078 0.491815946953357 no 1716 0.445462202910031 2705 4213774
SGTC_2974 9094440 9.66 µM -0.137917851851056 0.491466403923776 no 1717 0.445152670750065 2869 25236134
SGTC_3156 9099931 49.47 µM -0.138609603952234 0.491157700995305 no 1718 0.444879326859693 2662 18111053
SGTC_542 3381-0244 89.3 µM -0.138715741807417 0.491110336129093 no 1719 0.444837389101653 2828 1112843
SGTC_2956 9076196 2.52 µM -0.139457989491098 0.490779105708332 no 1720 0.44454412550286 2722 16423868
SGTC_1881 5652484 16 µM -0.139481209913106 0.490768743621565 no 1721 0.444534951554818 2700 2255129
SGTC_2321 7390090 138.78 µM -0.139514027257799 0.490754098929651 no 1722 0.444521986095431 2733 649046
SGTC_2396 5342950 42.78 µM -0.140132495884594 0.490478110565172 no 1723 0.444277652949845 2718 1886677
SGTC_2325 6158266 200 µM -0.142828452136364 0.4892751092741 no 1724 0.443212832946873 2744 3623240
SGTC_2744 captopril 92.04 µM -0.143227725107552 0.489096951987613 no 1725 0.443055167042572 2707 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2576 guaiol 23.12 µM -0.144617434680269 0.488476874897602 no 1726 0.442506465531874 2828 227829
SGTC_961 1252-1571 372 µM -0.144961770987479 0.488323239089971 no 1727 0.442370527618194 2774 6813498
SGTC_2065 5221596 34.26 µM -0.145327306700478 0.488160146438219 no 1728 0.4422262279773 2776 788581
SGTC_1673 st016611 27.3 µM -0.14610445373706 0.487813409993408 no 1729 0.44191946528727 2876 5226799
SGTC_2342 7990637 118.86 µM -0.148292652917529 0.486837160645114 no 1730 0.441055906688611 2775 2033102 YER133W GLC7
SGTC_1720 st037298 9.481 µM -0.148411861292266 0.48678397889746 no 1731 0.441008869888325 2759 597396
SGTC_3141 9094609 49.47 µM -0.14890114752648 0.486565698911869 no 1732 0.440815817857342 2665 25236309 YDL196W YDL196W
SGTC_2543 pimpinellin 60.67 µM -0.149015576777614 0.486514650403678 no 1733 0.440770670853958 2674 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_160 3453-0671 289.699 µM -0.149191687552211 0.486436085327065 no 1734 0.440701189479924 2692 5322268
SGTC_234 nsc-17383 10.7 µM -0.149617826627202 0.486245981885017 no 1735 0.440533071443782 2706 408974
SGTC_2426 5582046 32.21 µM -0.151780362487531 0.485281309505061 no 1736 0.439680085567808 2810 2251934
SGTC_2297 7971671 152.32 µM -0.152053560079023 0.485159446475447 no 1737 0.43957234594741 2811 909016
SGTC_2444 5485484 36.41 µM -0.15272679729943 0.484859146959229 no 1738 0.439306863742228 2784 6790631
SGTC_2332 7982454 138.89 µM -0.153598240624141 0.484470449781594 no 1739 0.438963262127944 2705 2981748
SGTC_2677 mitomycin C 100 µM -0.156062417693555 0.48337141328405 no 1740 0.43799191083351 2690 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2539 epi(13)torulosol 80 µM -0.157017641186992 0.482945411883157 no 1741 0.437615472450334 2773 6708597
SGTC_729 4092-0585 94.1 µM -0.157625941180531 0.482674138209644 no 1742 0.437375780502194 2677 2169061
SGTC_651 3253-0966 34.4 µM -0.158113814023655 0.482456575267717 no 1743 0.437183557760514 2713 781462
SGTC_2090 5301565 104.445 µM -0.158201697236635 0.482417385014272 no 1744 0.437148933197757 2715 2056344
SGTC_2393 9031399 185.94 µM -0.158517992131925 0.482276339268649 no 1745 0.437024322116894 2819 1526623 YDL150W RPC53
SGTC_512 prima-1 270 µM -0.158673888296949 0.482206821127909 no 1746 0.43696290581479 2852 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2832 7992762 51.95 µM -0.158886668117816 0.482111937964172 no 1747 0.436879082280838 2680 2985177
SGTC_1831 st055328 12 µM -0.159650555597565 0.481771312259607 no 1748 0.436578176047749 2798 1103068
SGTC_2876 9059903 25.97 µM -0.160119438873372 0.481562238701132 no 1749 0.436393494364816 2674 6916095
SGTC_2580 diallyl disulphide 81.36 µM -0.160169398964553 0.481539961953623 no 1750 0.436373817120454 2720 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_855 0428-0020 25 µM -0.161373461299676 0.481003099172311 no 1751 0.435899633761817 2703 6812414
SGTC_2021 4019055 173 µM -0.161558232468976 0.480920717123756 no 1752 0.43582687538881 2792 44827708 YER133W GLC7
SGTC_3206 9114350 49.47 µM -0.161796854412408 0.480814326382484 no 1753 0.435732915110354 2793 17087243
SGTC_108 0509-0257 621.132 µM -0.1624659002964 0.480516036368405 no 1754 0.435469489556345 2786 536624
SGTC_3303 9125618 40.5795 µM -0.162715265059121 0.480404861396541 no 1755 0.435371313697302 2789 22695467
SGTC_2549 cedrol 20.94 µM -0.162984770751756 0.480284708653064 no 1756 0.435265212756494 2824 6708665 A sedative which affects the nervous system.
SGTC_101 0490-5701 117.494 µM -0.162997039974639 0.480279238752563 no 1757 0.435260382631379 2671 4661669
SGTC_112 phenothiazine 287.218 µM -0.163701857760509 0.479965021111054 no 1758 0.434982927498978 2696 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1961 st076550 68.7 µM -0.164235922352704 0.479726935915143 no 1759 0.434772711546474 2811 1579337
SGTC_1338 1486-1223 76 µM -0.165657042998728 0.479093437915678 no 1760 0.434213426793496 2773 3444526
SGTC_674 0498-0004 451 µM -0.166410788370867 0.47875745949445 no 1761 0.433916842218747 2746 4231473
SGTC_3055 9094636 49.47 µM -0.16663049295157 0.478659530051143 no 1762 0.433830399608194 2860 25236176
SGTC_3114 9122766 49.47 µM -0.166946292249343 0.47851877034026 no 1763 0.43370615414423 2751 17176985
SGTC_2075 5212009 200 µM -0.167026057594544 0.478483217337525 no 1764 0.433674772962205 2814 780898
SGTC_713 1488-1073 324 µM -0.16724842261742 0.478384105723701 no 1765 0.433587292601853 2690 3312542
SGTC_1841 st054148 70 µM -0.167402078361819 0.478315619704537 no 1766 0.433526844977904 2777 675442
SGTC_1259 0671-0132 43 µM -0.168213963242032 0.477953764552167 no 1767 0.433207478195254 2734 X1259
SGTC_39 0986-0283 58.349 µM -0.168262071259177 0.477932323491224 no 1768 0.433188555570344 2805 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_369 0957-0393 4.5 µM -0.170683222716279 0.47685333443723 no 1769 0.432236427783908 2756 6997992
SGTC_2247 cerulenin 830 nM -0.170845164854919 0.476781170695039 no 1770 0.432172757346538 2941 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1621 st003705 32.4 µM -0.171150749453418 0.476644999886245 no 1771 0.432052616116134 2883 24207032
SGTC_824 1304-0008 100 µM -0.171206196970683 0.476620292344948 no 1772 0.43203081748076 2737 768245
SGTC_2413 inermin 26.06 µM -0.172155425580505 0.476197327911262 no 1773 0.431657669920633 3011 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_720 r052-1644 49.9 µM -0.175993643630229 0.474487344170476 no 1774 0.430149468077122 2826 1422863 YOR257W CDC31
SGTC_2732 terfenadine 20 µM -0.178153053718043 0.473525499101671 no 1775 0.429301388774153 2711 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_934 2950-0684 338 µM -0.178912429806569 0.473187293972762 no 1776 0.429003231344757 2943 1121253
SGTC_1803 st050068 52.4 µM -0.179234171176277 0.473044005071159 no 1777 0.428876916714211 2717 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_684 1140-0066 328 µM -0.179264333317462 0.473030572410501 no 1778 0.428865075527489 2787 6813534
SGTC_3226 9131256 49.47 µM -0.179497792006053 0.472926603000709 no 1779 0.428773425449914 2711 17178073
SGTC_3340 9146634 11.102 µM -0.179642214586042 0.472862286204379 no 1780 0.42871673065771 2792 4907387
SGTC_1457 k015-0032 57.3 µM -0.180369166025018 0.472538558217366 no 1781 0.428431379629569 2703 4302660
SGTC_1116 jasmonic acid 1.58368 µM -0.180374202546232 0.4725363154031 no 1782 0.428429402768826 2874 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1376 2910-0861 41.3 µM -0.181510141406035 0.472030492623885 no 1783 0.42798358683731 2725 1112859
SGTC_943 3253-1379 105 µM -0.181521124407656 0.472025602216499 no 1784 0.427979276844332 2874 668464
SGTC_293 4049-0273 38.5 µM -0.181634022405148 0.471975332305499 no 1785 0.42793497346342 2746 1380311
SGTC_270 tamoxifen 5.46 µM -0.181928171718486 0.471844359009511 no 1786 0.427819547791852 2902 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_841 0251-0215 91.2 µM -0.182577334889587 0.471555322587752 no 1787 0.427564834766376 2780 3888614
SGTC_618 k072-0232 33.2 µM -0.18267359838113 0.471512463056006 no 1788 0.427527066298508 2824 5872756 YGL099W LSG1
SGTC_1258 0671-0043 57.1 µM -0.18309840438592 0.471323330019222 no 1789 0.427360403863384 2804 4298767
SGTC_1650 st011916 45.8 µM -0.183487807842469 0.471149964660895 no 1790 0.427207642154531 2786 242528
SGTC_1284 0929-0043 16 µM -0.184480513238079 0.470708029535237 no 1791 0.426818256489098 2797 1239883
SGTC_891 0929-0073 133 µM -0.185815030715696 0.47011398257265 no 1792 0.426294908501055 2876 5603632
SGTC_2962 9082311 13.18 µM -0.185890962091059 0.470080184475878 no 1793 0.42626513494035 2733 16459453
SGTC_2960 9079389 5.97 µM -0.186252977420326 0.469919049454673 no 1794 0.426123190370314 2867 16457355
SGTC_1047 2043-3044 82 µM -0.187051201916263 0.469563772768103 no 1795 0.425810244004385 2741 669592
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.187148391774913 0.469520516798419 no 1796 0.425772143608584 2939 165506
SGTC_158 k038-0087 26.446 µM -0.187704513751266 0.469273012358993 no 1797 0.425554145852644 2733 X158
SGTC_2891 9063876 19.48 µM -0.188206322820081 0.469049690296698 no 1798 0.425357458083466 2828 6472478
SGTC_2642 cholecalciferol 100 µM -0.188995062975092 0.468698693872788 no 1799 0.425048343118338 2839 9821465 A vitamin D precursor, similar to steriods.
SGTC_1847 st056231 15 µM -0.189575303781854 0.468440497039925 no 1800 0.424820970488129 2745 5393180
SGTC_2996 9066192 71.4286 µM -0.189614065613909 0.468423249186273 no 1801 0.424805782202521 2785 6472854
SGTC_2783 7738165 71.43 µM -0.189767063338364 0.468355170362905 no 1802 0.424745833258968 2813 17201110
SGTC_2581 avocatin a 64 µM -0.190640876845177 0.467966370640373 no 1803 0.424403481194797 2806 6710728 A skin care supplement.
SGTC_366 0181-0206 4.31 µM -0.190767754471734 0.467909919494362 no 1804 0.424353776447398 2865 274874
SGTC_1763 st044482 94.5 µM -0.191375189132462 0.467639665022928 no 1805 0.424115828506651 2876 88505
SGTC_335 4077-0256 27.6 µM -0.191611381139456 0.467534584578927 no 1806 0.424023313423841 2846 3121989
SGTC_1678 st019265 80.2 µM -0.192067018146854 0.467331880734359 no 1807 0.423844854799971 2953 5367020
SGTC_1552 6-methylflavone 10.6 µM -0.192482504276297 0.467147046600224 no 1808 0.423682135619004 2756 689013
SGTC_2804 7954240 19.48 µM -0.193201726796592 0.46682710835022 no 1809 0.423400493213428 2898 828705
SGTC_2458 5808907 16.39 µM -0.194502900190855 0.466248350238814 no 1810 0.422891062534426 2792 2731747
SGTC_610 4215-0184 155 µM -0.194969176752412 0.466040969097049 no 1811 0.422708538961105 2821 5605015
SGTC_1614 st002383 48.6 µM -0.196717858308508 0.465263308159978 no 1812 0.42202416712562 2771 1947235
SGTC_2093 5331342 194.4 µM -0.196935520860606 0.465166520075877 no 1813 0.421938998167222 2895 33839
SGTC_1920 st075728 45.7 µM -0.197444818886998 0.464940058404218 no 1814 0.42173972973257 2940 3400306
SGTC_14 0354-0009 295 µM -0.198064722099626 0.464664430965428 no 1815 0.42149721284826 2717 1713507
SGTC_2223 6903751 107.57 µM -0.19869515254254 0.464384140196069 no 1816 0.421250608066839 2856 5598863
SGTC_661 1304-0007 33.6 µM -0.199067318187274 0.464218682814674 no 1817 0.42110504293542 2771 3117130
SGTC_1444 4112-3581 28 µM -0.19993857055731 0.463831365733127 no 1818 0.420764312243204 2760 2877249
SGTC_912 3474-0017 2.18 µM -0.204594898220234 0.461761975496196 no 1819 0.418944320859706 2928 3360550
SGTC_3314 9135860 59.4275 µM -0.204758612864648 0.461689235055145 no 1820 0.418880361996274 2798 25252478
SGTC_2079 5212404 121 µM -0.205683249870062 0.46127843152759 no 1821 0.418519171737812 2864 758462
SGTC_839 0122-0028 230 µM -0.20595614350714 0.461157196507405 no 1822 0.4184125846154 2774 759448
SGTC_1922 5578187 25 µM -0.206150236126722 0.461070971619198 no 1823 0.418336779333488 3012 1350412
SGTC_504 lovastatin 124 µM -0.206518424274675 0.460907410504395 no 1824 0.418192987218212 2783 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2243 6634756 200 µM -0.206993980128955 0.460696162963678 no 1825 0.418007279926514 3049 885676
SGTC_734 2023-0417 80 µM -0.207144520993898 0.460629293237665 no 1826 0.417948496661615 2897 3935732
SGTC_1451 4152-0210 104 µM -0.207392908123148 0.460518962977932 no 1827 0.417851510351237 2936 659563
SGTC_1415 3966-0071 78.1 µM -0.208852998325215 0.459870472049579 no 1828 0.417281498418625 2779 2893185
SGTC_2755 lomerizine 42.69 µM -0.209255766491519 0.459691603522776 no 1829 0.417124290269223 2808 3949 A calcium channel blocker.
SGTC_389 tpck 16.7 µM -0.209813459459591 0.459443946681567 no 1830 0.416906633873722 2844 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2836 9010338 19.48 µM -0.210041262485877 0.459342789845141 no 1831 0.416817734237365 2794 2994051
SGTC_3142 9086498 49.47 µM -0.210225145851216 0.45926113762775 no 1832 0.416745977255631 2914 25236367
SGTC_2777 climbazole 1.536 µM -0.210330932941516 0.459214164333945 no 1833 0.41670469711485 2824 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1341 1486-1360 280 µM -0.210471327645218 0.459151824887634 no 1834 0.41664991384152 2760 3976547
SGTC_1826 st055655 41.6 µM -0.211671399098369 0.458618998423209 no 1835 0.416181701353298 2837 676168
SGTC_2659 sanguinarine 24.21 µM -0.21180110781458 0.458561412756566 no 1836 0.416131102109193 2779 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.212230188234242 0.458370923804756 no 1837 0.415963728164032 2980 688798
SGTC_2551 apiole 73.87 µM -0.212432964182759 0.458280905360831 no 1838 0.415884635448103 2764 10659 A possible DNA adduct former.
SGTC_1776 st049249 45.9 µM -0.213143781399709 0.457965368789787 no 1839 0.415607408266894 2818 1822314
SGTC_476 mead acid 10 µM -0.214525181307381 0.457352231966347 no 1840 0.415068766088741 2786 5312531 An omega 9 fatty acid.
SGTC_1251 0490-5699 265 µM -0.214892017344012 0.457189428129501 no 1841 0.414925754373497 2914 3883818
SGTC_1245 0418-0076 17.2 µM -0.215232142809631 0.457038485008103 no 1842 0.414793165895755 2970 6790114
SGTC_1262 0737-0114 49.6 µM -0.215287498092398 0.457013919661646 no 1843 0.414771588092288 2890 765919
SGTC_301 4119-0100 24.5 µM -0.215709395102688 0.456826697293744 no 1844 0.414607138695876 2808 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2640 pentamidine 10.38 µM -0.215909514857761 0.456737894858806 no 1845 0.41452914012008 2898 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_881 0833-0569 170 µM -0.215947155925359 0.456721192009191 no 1846 0.414514469532838 2813 5418700
SGTC_2533 agelasine 13.65 µM -0.216078094608118 0.456663089865987 no 1847 0.414463437175862 2954 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.216513232799688 0.456470010260893 no 1848 0.414293855747529 2765 2346 DNA damaging agent; causes G2/M arrest.
SGTC_290 2043-6722 48.1 µM -0.217270653110241 0.456133952110146 no 1849 0.413998713121426 2872 773758 YLR208W SEC13
SGTC_2364 9055074 200 µM -0.217477976899593 0.456041970533998 no 1850 0.413917934088398 2876 6470630
SGTC_2340 7987427 183.45 µM -0.217791500782163 0.455902876545453 no 1851 0.413795783506592 2916 2239331
SGTC_15 0266-0086 27.098 µM -0.218399734145375 0.455633050951877 no 1852 0.41355883633009 2862 1712902 YIL048W NEO1
SGTC_2636 apigenin dimethyl ether 100 µM -0.218828685508319 0.455442771063282 no 1853 0.413391750286212 2936 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_978 1416-0512 87.4 µM -0.219504082323561 0.45514319039165 no 1854 0.413128700085983 2849 6814003
SGTC_654 1124-0271 80.9 µM -0.219598276576432 0.455101411380246 no 1855 0.413092016871621 2820 5403748
SGTC_3018 9082602 49.47 µM -0.220814121740358 0.454562178960479 no 1856 0.412618583709663 2778 17332089
SGTC_1856 st057054 55.7 µM -0.221116662113367 0.454428014008942 no 1857 0.412500798425169 3044 1266018
SGTC_292 k038-0015 474 µM -0.221797151580128 0.454126262277239 no 1858 0.412235898474263 2918 46368540
SGTC_1676 st018489 23.4 µM -0.221921460654423 0.454071142341487 no 1859 0.41218751193361 2848 3696235
SGTC_2779 methotrexate 400 µM -0.222188693836688 0.45395265136668 no 1860 0.412083497585276 2852 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1087 pterostilbene 9.05 µM -0.222371962289607 0.45387139265279 no 1861 0.412012168139451 2932 5281727 Similar to reservatol, lowers cholesterol.
SGTC_576 1073-0113 22.7 µM -0.224924362375455 0.452739895746788 no 1862 0.411019058208017 2848 5439563
SGTC_2078 5212016 200 µM -0.224993543631429 0.452709232508468 no 1863 0.410992148471865 2781 1899708
SGTC_906 1165-0455 526 µM -0.22523792978859 0.452600915384194 no 1864 0.410897091871969 2803 3252859
SGTC_1632 st005650 90 µM -0.226419689597781 0.452077184302487 no 1865 0.410437507723227 2936 2759605
SGTC_2673 kobusone 100 µM -0.226834141489985 0.451893527647113 no 1866 0.410276357259449 2828 6710676 An epoxy ketone and protein crosslinker.
SGTC_2984 9022109 38.96 µM -0.226968255222491 0.45183409984113 no 1867 0.410224213339902 2878 6459207
SGTC_696 1560-0013 611 µM -0.227192503253433 0.451734734587599 no 1868 0.410137028415057 3019 1650269
SGTC_2928 9011484 9.79 µM -0.227694282345988 0.451512405105207 no 1869 0.409941958862148 2949 2994751
SGTC_2455 5377712 9.75 µM -0.228404071864701 0.451197935852521 no 1870 0.409666062110672 2891 2243908
SGTC_2592 piperlongumine 83.33 µM -0.229542342232759 0.450693693986539 no 1871 0.409223707335399 2894 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_858 0438-0351 2.77 µM -0.229895364956246 0.45053732474045 no 1872 0.409086539052635 2841 2799119
SGTC_1355 1499-0035 1.68 µM -0.232239781682782 0.449499075691311 no 1873 0.408175890484814 2809 1548538
SGTC_265 mycophenolic acid 32.932 µM -0.232657162026781 0.449314270556278 no 1874 0.408013818073966 3053 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_673 1082-0474 110 µM -0.232710374408174 0.449290710290425 no 1875 0.407993156374875 2832 3098046
SGTC_1266 0828-0227 32.9 µM -0.232841637855694 0.449232592969764 no 1876 0.407942189521627 2935 3913820
SGTC_2716 st080858 38.6235 µM -0.232920885095331 0.449197506522429 no 1877 0.407911420228796 2951 5296050
SGTC_2959 9079155 11 µM -0.234905478900935 0.448318964577054 no 1878 0.407141048499592 2986 16189457
SGTC_762 1165-0429 115 µM -0.235370710834588 0.44811305175104 no 1879 0.406960508463509 2969 5967793
SGTC_3004 9076122 71.4286 µM -0.235501304244216 0.44805525328941 no 1880 0.406909833338328 2973 44782551
SGTC_2976 9009005 19.48 µM -0.237096893217064 0.447349161675758 no 1881 0.406290811257613 3048 2993148
SGTC_3227 9130768 49.47 µM -0.239321838762484 0.446364841622732 no 1882 0.405428016238518 2829 17720899
SGTC_2041 5107442 45.335 µM -0.239605531644341 0.446239358986851 no 1883 0.405318038025085 2985 793005
SGTC_186 3455-3465 67.277 µM -0.239760858344988 0.446170657379413 no 1884 0.405257826240299 2814 755278
SGTC_1744 st037937 38.9 µM -0.240412034217635 0.445882657354277 no 1885 0.40500542489449 3019 1016152
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.241242524922945 0.445515391972934 no 1886 0.404683576925601 2849 279621
SGTC_3282 9108498 15.4605 µM -0.241973063514449 0.445192366750529 no 1887 0.404400517646802 2933 16459645
SGTC_1422 4031-0024 15.5 µM -0.242353060487698 0.445024356314791 no 1888 0.404253301296671 2889 782427
SGTC_522 1273-0010 11.6 µM -0.244085789523343 0.444258379622816 no 1889 0.403582189035953 3067 5705015
SGTC_2492 derrusnin 100 µM -0.244755477623775 0.443962390405083 no 1890 0.403322884597769 2775 1715307 Part of coumarin class of compounds.
SGTC_871 0574-0004 149 µM -0.244987412200517 0.443859887076093 no 1891 0.403233089014724 2842 9551173
SGTC_3176 9106582 49.47 µM -0.245609326596995 0.443585050985557 no 1892 0.402992334389154 2908 17018027
SGTC_1184 1269-1718 139 µM -0.24702473236732 0.442959656948843 no 1893 0.402444541716204 2987 5403821
SGTC_51 1013-0126 23.419 µM -0.247233712774834 0.442867331399541 no 1894 0.402363677974065 3106 1627850
SGTC_1352 1496-0991 99 µM -0.247561452908552 0.442722545186175 no 1895 0.402236869267968 2833 3000039
SGTC_83 0170-0301 39.027 µM -0.247814356746476 0.442610824734507 no 1896 0.402139023137803 2833 3089716
SGTC_1466 k213-0079 57.5 µM -0.247943588643569 0.442553738212503 no 1897 0.402089026892134 2839 3657981
SGTC_541 4513-1321 94 µM -0.248074025550114 0.442496120602601 no 1898 0.402038566086089 2859 747515
SGTC_2522 biochanin a 4.94 µM -0.248286655428162 0.442402198678806 no 1899 0.401956311617559 2958 5280373 A possible chelator.
SGTC_1146 3579-1023 7 µM -0.248924735437348 0.442120368270455 no 1900 0.401709500648369 2951 X1146
SGTC_3320 9137005 35.139 µM -0.248940514476976 0.442113399274937 no 1901 0.401703397772009 2892 4908713
SGTC_1112 tnp00069 1.16933 µM -0.249356617053085 0.441929629227248 no 1902 0.401542469980704 2953 145826
SGTC_677 0929-0063 136 µM -0.249763199878929 0.441750075611202 no 1903 0.401385240083415 2843 1539583
SGTC_1279 0874-0590 65.2 µM -0.249902170357634 0.441688706720976 no 1904 0.401331502383183 2911 3523074
SGTC_2888 9058547 12.99 µM -0.251660909937531 0.440912174747243 no 1905 0.400651587009969 2862 16476514
SGTC_365 0121-0052 13.6 µM -0.251905819560227 0.440804058351288 no 1906 0.400556930629308 2998 3101739
SGTC_1192 1488-0095 21.4 µM -0.253759062303852 0.439986080028584 no 1907 0.39984085096105 2924 915875
SGTC_2920 7982904 15.77 µM -0.253772239551267 0.439980264810315 no 1908 0.399835760570148 2953 6456808
SGTC_2520 obtusaquinone 4.71 µM -0.254520890146565 0.439649900981485 no 1909 0.399546583677404 3020 5967872
SGTC_2989 9073649 71.4286 µM -0.255416759662285 0.439254627773514 no 1910 0.39920061381884 2845 21367202
SGTC_665 3914-0008 307 µM -0.25584304352645 0.43906656516051 no 1911 0.399036017881062 2852 1069549
SGTC_1725 st036284 20.55 µM -0.255994993119429 0.438999533251862 no 1912 0.398977351723134 3096 707914
SGTC_3049 9092223 49.47 µM -0.256350069655681 0.438842899590511 no 1913 0.398840269263448 2957 8623917
SGTC_1652 st011932 78 µM -0.259409803523606 0.437493569336008 no 1914 0.397659533216373 2963 1551076
SGTC_2709 st078560 56 µM -0.259588296884012 0.437414876765595 no 1915 0.397590682337443 3024 17250903
SGTC_1348 1493-0373 93.8 µM -0.260138591691444 0.437172283264057 no 1916 0.397378435250951 2926 3010129
SGTC_506 n9-isopropylolomoucine 153 µM -0.260293278870558 0.437104094784652 no 1917 0.397318778329409 3014 6610355
SGTC_2729 fluphenazine 10.66 µM -0.260323592944119 0.437090732095298 no 1918 0.397307087633493 2857 3372 An atypical antipsychotic.
SGTC_1155 4088-0394 48.2 µM -0.260414196189356 0.43705079387823 no 1919 0.397272146822424 2819 2326248
SGTC_224 benfluorex 43.875 µM -0.261385393912504 0.436622727011057 no 1920 0.396897659798019 2966 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_360 0957-0399 1.01 µM -0.261702534107647 0.436482959772148 no 1921 0.396775393336674 3015 6752301 YPR165W RHO1
SGTC_487 nimodipine 119 µM -0.262365359818824 0.436190870677034 no 1922 0.396519888169906 2941 4497 L-type voltage-gated calcium channels inhibitor
SGTC_92 0063-0024 660.874 µM -0.262859704105794 0.435973049363843 no 1923 0.396329357915455 2815 3594437
SGTC_2957 9076800 11.52 µM -0.262955534606076 0.435930826127669 no 1924 0.39629242577204 2909 16459615
SGTC_1663 st014140 55.4 µM -0.26332938871704 0.435766111752255 no 1925 0.396148354931401 2908 4207120
SGTC_936 3005-4620 401 µM -0.263486859829151 0.435696735733683 no 1926 0.396087675088097 3075 777207
SGTC_529 4076-0302 30.3 µM -0.2647699425675 0.43513153029359 no 1927 0.395593346552699 2881 5816522
SGTC_2713 st079149 53.4 µM -0.265889576612122 0.434638433182245 no 1928 0.39516212644839 2959 3103253
SGTC_1301 naphtanilide LB 4.81 µM -0.266049963439827 0.434567805657156 no 1929 0.395100364955551 3012 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1467 k284-1082 293 µM -0.267784808816505 0.433803987584731 no 1930 0.394432482313095 2980 3334705
SGTC_1937 st074714 47.2 µM -0.268169140460525 0.433634807308786 no 1931 0.394284563809936 2828 17250970
SGTC_2937 9044753 11.33 µM -0.268264614484042 0.433592782152207 no 1932 0.394247820890996 2843 6465530 YGL099W LSG1
SGTC_2798 7813637 45.45 µM -0.268596767787172 0.433446582847764 no 1933 0.394119999927345 3020 956368
SGTC_1060 3448-7350 82 µM -0.271279297436052 0.432266186490498 no 1934 0.393088113957878 3010 570178
SGTC_1575 cyproterone acetate 48 µM -0.272720779952052 0.43163213836235 no 1935 0.392533929956492 2946 9880 An androgen receptor antagonist and liver toxin.
SGTC_2817 7995342 71.43 µM -0.27351341999305 0.431283563952176 no 1936 0.392229288916497 2845 18879975
SGTC_1332 1480-0653 17.5 µM -0.274305013472701 0.43093550318597 no 1937 0.391925116016442 3024 5749438
SGTC_2349 9023730 187.07 µM -0.274597399663539 0.430806955593889 no 1938 0.391812782167584 3041 4126287
SGTC_2431 5490079 200 µM -0.274975739937948 0.430640629169804 no 1939 0.391667438418613 2953 5722345
SGTC_359 0081-0058 15.9 µM -0.275209883499191 0.430537700846082 no 1940 0.391577497061171 3294 3494159
SGTC_1012 4112-3522 18 µM -0.276632489576547 0.42991243210338 no 1941 0.391031157399884 3059 3112398
SGTC_3294 9122953 26.2835 µM -0.276907157205479 0.429791729430041 no 1942 0.390925698379935 2871 16459826
SGTC_1965 Pectolinarigenin 58.4 µM -0.277801267051418 0.42939885841618 no 1943 0.390582459243725 2895 5320438 An anti-inflammatory.
SGTC_626 0214-0009 33 µM -0.280626866617682 0.428157754063064 no 1944 0.389498303583796 3030 3437874
SGTC_475 α-linolenic acid 10 µM -0.280725072411361 0.428114631269657 no 1945 0.389460638361662 3127 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_327 1273-0057 3.96 µM -0.280907686885513 0.428034446366418 no 1946 0.389390602334879 2948 3108138
SGTC_1766 st045414 44.774 µM -0.281402987843924 0.427816977702132 no 1947 0.389200663353466 2896 253960
SGTC_3173 9105693 49.47 µM -0.282283611829527 0.427430381875888 no 1948 0.388863025343562 3068 17096658
SGTC_2281 7943571 200 µM -0.283544754185836 0.42687685908915 no 1949 0.388379639873728 3107 1244024
SGTC_213 1246-0773 967 nM -0.284004196649569 0.426675242812033 no 1950 0.388203582276008 2943 6251622
SGTC_985 1493-0307 8.71 µM -0.285458406782987 0.426037221020893 no 1951 0.387646482922087 3057 3278274
SGTC_1769 st044406 64.4 µM -0.285615654290291 0.425968241639583 no 1952 0.387586256159691 2909 670903
SGTC_726 3448-4391 34.2 µM -0.285642767227531 0.42595634830229 no 1953 0.387575872011337 3090 1356692
SGTC_350 k064-0020 19.8 µM -0.286482557971701 0.42558799983406 no 1954 0.387254275315515 3111 2790705
SGTC_570 0987-0065 62.6 µM -0.286683001034305 0.425500091215379 no 1955 0.38717752735217 2847 3104428
SGTC_2019 4016004 108 µM -0.286834344043329 0.425433718935295 no 1956 0.387119582308329 2988 45595336
SGTC_137 0438-0332 85.389 µM -0.286977011344856 0.42537115336759 no 1957 0.387064961255634 2968 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2896 9052656 71.43 µM -0.288154087256046 0.424855028296693 no 1958 0.386614395944218 3025 6469436
SGTC_363 0455-0021 3.06 µM -0.288751542841386 0.424593104772914 no 1959 0.386385758191142 2896 4597466
SGTC_1611 st001856 99.4 µM -0.290347580402205 0.423893568160958 no 1960 0.385775170936052 2943 647478
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.291968658691935 0.423183301721054 no 1961 0.3851552935717 2931 115019
SGTC_2372 9071633 200 µM -0.291988078576094 0.423174794515059 no 1962 0.385147869458221 3048 21321366
SGTC_57 miconazole 162.5 nM -0.292617230068912 0.422899203550518 no 1963 0.384907371137845 2875 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2685 mycophenolic acid 18.85 µM -0.292732086603373 0.422848896329161 no 1964 0.384863471061392 2957 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2726 cimetidine 79.27 µM -0.293150150346535 0.422665794824025 no 1965 0.384703692617939 2921 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3001 9076041 71.4286 µM -0.293767113509506 0.422395610860237 no 1966 0.384467933219547 2908 16004211
SGTC_1064 honokiol 6.76 µM -0.294032025337226 0.422279610385778 no 1967 0.384366715885149 3000 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2844 9010103 25.97 µM -0.294182490927825 0.4222137270124 no 1968 0.38430922960286 3096 2480525
SGTC_2339 9000433 200 µM -0.296463481393542 0.421215232427389 no 1969 0.383438075856581 2983 2988954
SGTC_1478 0453-0656 35.7 µM -0.296587435105071 0.421160986630615 no 1970 0.383390752404215 2989 5258496
SGTC_2826 7992541 19.48 µM -0.29780027990244 0.420630289123565 no 1971 0.382927800454773 2887 2985066
SGTC_1282 0886-0010 32.4 µM -0.297875151343907 0.42059753277508 no 1972 0.38289922693682 3093 2836211 YNL267W PIK1
SGTC_2887 9044784 58.44 µM -0.299258396475428 0.419992460456419 no 1973 0.382371447798735 2942 6465546
SGTC_1278 0874-0585 172 µM -0.300472455953225 0.419461550681276 no 1974 0.381908401642946 3006 766306
SGTC_3056 9094900 49.47 µM -0.300583391727074 0.419413045618766 no 1975 0.381866098796752 2982 25236784
SGTC_926 2268-1401 59.4 µM -0.300896191579158 0.419276285004456 no 1976 0.381746827251342 2901 2931578
SGTC_2824 7998404 51.95 µM -0.301031438545224 0.419217156095804 no 1977 0.381695260642759 2913 837851
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.301102138544489 0.419186247338835 no 1978 0.381668305167952 3081 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3084 9116877 49.47 µM -0.302046828452183 0.418773293977327 no 1979 0.381308182548847 3025 27241325
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.30354385137747 0.418119082097598 no 1980 0.380737717118848 3021 279621
SGTC_1357 1503-1303 39.5 µM -0.303591507510495 0.418098259668201 no 1981 0.380719561208796 2952 292895
SGTC_2355 9061122 103.12 µM -0.305500617108044 0.417264300408369 no 1982 0.379992450018365 3068 5302957
SGTC_1366 1683-0113 21.9 µM -0.305730228997976 0.417164023688145 no 1983 0.379905027620359 2942 708623
SGTC_2852 9023854 51.95 µM -0.305736283597065 0.41716137958028 no 1984 0.379902722476196 3095 19798528
SGTC_624 k048-0052 28 µM -0.306146376701396 0.416982296283602 no 1985 0.379746599246503 2994 6835531
SGTC_3160 9100216 49.47 µM -0.307851276385743 0.416237969780253 no 1986 0.37909775106069 2916 17191039
SGTC_431 k089-0097 107 µM -0.308096442818102 0.416130959452163 no 1987 0.379004473944071 3064 5499420
SGTC_2839 9003951 25.97 µM -0.309079710410035 0.415701845023538 no 1988 0.378630446403496 3064 2990634
SGTC_638 3970-0837 4.09 µM -0.309279130204319 0.415614827130696 no 1989 0.37855460247699 2963 4118451 YLR208W SEC13
SGTC_13 0199-0087 65 µM -0.311148272215669 0.414799418740725 no 1990 0.377843952613479 2947 4589825
SGTC_1998 st075797 76.8 µM -0.312272154681498 0.414309304333207 no 1991 0.377416850020945 3076 24208315
SGTC_957 1187-1561 14.1 µM -0.312387523079187 0.414259000814083 no 1992 0.377373015705489 2963 1538454
SGTC_2388 9080168 200 µM -0.314416817923313 0.413374407960244 no 1993 0.37660224225173 2938 15943073
SGTC_1719 st032227 49.2 µM -0.316762569409072 0.412352415961504 no 1994 0.37571188398774 2964 3125804
SGTC_2279 7948423 32.93 µM -0.319080636989714 0.411343068686284 no 1995 0.374832683136897 3162 1247112
SGTC_26 0302-0163 425.158 µM -0.319944231133048 0.410967186800668 no 1996 0.374505303568269 2970 3100915
SGTC_848 0368-0089 85.6 µM -0.320337100140068 0.410796216440472 no 1997 0.374356400926868 3088 762535
SGTC_1651 st011928 86.1 µM -0.321043747472434 0.410488737404308 no 1998 0.37408861925456 3072 720198
SGTC_300 r073-0011 5.04 µM -0.321132398832815 0.410450166971641 no 1999 0.374055029400157 3072 2735780
SGTC_3302 9125395 16.351 µM -0.321354113015692 0.410353707360484 no 2000 0.37397102644841 3013 17599668
SGTC_1097 itavastatin 7.23 µM -0.322342940986855 0.40992357112053 no 2001 0.373596452752876 3015 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1749 st037932 54.2 µM -0.32268870224533 0.40977319189202 no 2002 0.373465504560462 3094 594497
SGTC_2456 5770359 74.46 µM -0.32358742568555 0.409382379296423 no 2003 0.373125204523831 3123 3118787
SGTC_1597 7-benzyloxygramine 47.5 µM -0.324148963319356 0.409138238643819 no 2004 0.372912629506891 2974 260807
SGTC_1124 fisetin 1.16336 µM -0.325689435378641 0.408468666258946 no 2005 0.372329669074112 3036 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2046 4110841 106 µM -0.325948656596854 0.408356020915639 no 2006 0.372231600765703 3142 44119630 YMR134W ERG29
SGTC_2048 5246248 200 µM -0.326551441927187 0.408094108068308 no 2007 0.372003587676401 3101 677046
SGTC_3083 9117465 49.47 µM -0.326916439748177 0.407935534878403 no 2008 0.371865543284833 3068 16420915
SGTC_2949 9072542 2.23 µM -0.327332995959575 0.407754580587811 no 2009 0.37170801932326 3074 16457352
SGTC_116 0155-0182 31.788 µM -0.327901799103494 0.407507521185688 no 2010 0.371492956694786 2999 771486
SGTC_1505 k297-0037 20.6 µM -0.328655696248366 0.407180122985532 no 2011 0.371207972442489 3013 4089396
SGTC_1836 st055642 81 µM -0.329235366558221 0.406928431114919 no 2012 0.370988896512143 3002 8571
SGTC_641 4092-0595 30 µM -0.330250900425131 0.406487580728938 no 2013 0.370605194634061 3063 786260
SGTC_885 0865-0106 16.8 µM -0.33127771569115 0.406041953488891 no 2014 0.37021736109273 2988 2793380
SGTC_2905 7799065 20.05 µM -0.332368413969166 0.40556873498467 no 2015 0.369805543077296 3169 1296806
SGTC_722 3534-0461 190 µM -0.332699499822414 0.405425114870959 no 2016 0.369680563572328 3021 658262
SGTC_2557 derrustone 83.84 µM -0.336533656147349 0.403762847213495 no 2017 0.368234238056856 3116 629853 An antioxidant.
SGTC_2703 st077852 53.4 µM -0.33707988359427 0.403526175329127 no 2018 0.368028340754112 3114 6281836
SGTC_2050 5263056 171 µM -0.337268075521172 0.40344464286222 no 2019 0.367957411663863 3146 763468 YGL055W OLE1
SGTC_698 k064-0052 127 µM -0.339452179624253 0.402498707162984 no 2020 0.367134557894579 3065 5088751
SGTC_3287 9117173 37.0625 µM -0.339570252269333 0.402447586096495 no 2021 0.367090091772185 3056 2789709
SGTC_3309 9129340 25.759 µM -0.340290108533115 0.402135951211673 no 2022 0.366819032709026 3040 17158987
SGTC_932 2857-0803 154 µM -0.342289163442183 0.40127086182664 no 2023 0.366066644960384 3231 674898
SGTC_1206 3978-0017 132 µM -0.342501263602118 0.401179103967922 no 2024 0.365986846609419 3251 3873677
SGTC_341 1486-1430 230 µM -0.342829028318262 0.401037318526983 no 2025 0.365863543234196 2968 2054753 YPL210C SRP72
SGTC_1373 2887-0003 58.5 µM -0.34298185307761 0.400971213589681 no 2026 0.365806056092706 3070 776948
SGTC_474 dl-dihydrosphingosine 5 µM -0.344151076796006 0.40046555533154 no 2027 0.365366336261133 3158 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM -0.344681531491862 0.400236202683352 no 2028 0.365166901989482 3010 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3209 9113616 49.47 µM -0.344846598455683 0.400164839709808 no 2029 0.365104849441855 3220 16649353
SGTC_1454 4239-0054 42.6 µM -0.345809048126605 0.399748812786421 no 2030 0.364743112396121 3189 1340767
SGTC_142 0335-0849 62.6745 µM -0.346044007088375 0.39964726707024 no 2031 0.364654821257108 3125 3889043 YPR107C YTH1
SGTC_2448 5185112 27.17 µM -0.347483225339487 0.399025407034527 no 2032 0.364114159290934 3136 5718189
SGTC_1230 0170-0365 3.77 µM -0.349181752565538 0.398291833986629 no 2033 0.363476432211473 3146 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_174 3553-0389 74.3 µM -0.350053050540667 0.397915670355526 no 2034 0.363149442305916 3159 738071
SGTC_1704 st028805 70.8 µM -0.350359798720359 0.397783261175974 no 2035 0.363034346331226 3085 2876101
SGTC_2693 st077581 40.7 µM -0.350454103361585 0.397742556534919 no 2036 0.362998964467777 3157 25238761
SGTC_3243 9134147 49.47 µM -0.351204525881837 0.397418691938341 no 2037 0.36271745748568 3098 24282180
SGTC_3144 9087057 49.47 µM -0.351796576727658 0.397163226692261 no 2038 0.362495413020679 3171 17249618
SGTC_3131 9127911 49.47 µM -0.351978768248826 0.397084621366716 no 2039 0.362427092686117 3250 45595681
SGTC_1699 st031318 29.054 µM -0.352442783020518 0.396884444154529 no 2040 0.362253110723457 3132 5340658
SGTC_3170 9103054 49.47 µM -0.353283628301639 0.396521770507408 no 2041 0.361937908978825 3088 16432970
SGTC_2437 5741531 144.16 µM -0.35328386593025 0.396521668025999 no 2042 0.361937819913886 3208 2262990
SGTC_1114 scopoletin 1.73284 µM -0.35399223994601 0.396216201401431 no 2043 0.361672349410192 3165 5280460 A coumarin with genotoxic properties.
SGTC_1091 telmisartan 47.6 µM -0.354162341786032 0.396142859184902 no 2044 0.361608611889028 3131 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1686 st019653 115.5 µM -0.354478925963198 0.396006368479304 no 2045 0.361489997349008 3155 97252
SGTC_1887 st057648 70.8 µM -0.35451978924362 0.395988751793469 no 2046 0.361474688080343 3147 688672
SGTC_2676 harmalol 100 µM -0.355060488232261 0.395755669519426 no 2047 0.361272138203666 3128 5459187 A monoamine oxidase inhibitor
SGTC_2480 5767542 37.17 µM -0.355538811773547 0.395549506862547 no 2048 0.361092987045958 3057 2867358
SGTC_991 3996-0057 64.7 µM -0.355659107408977 0.395497662730121 no 2049 0.361047936347056 3101 715343
SGTC_969 1313-0238 134 µM -0.356435113859525 0.39516326963007 no 2050 0.360757368382788 3019 5212874
SGTC_2129 girgensonine 121.053 µM -0.356510316897452 0.395130867584698 no 2051 0.360729213615416 3081 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1027 k015-0025 8.67 µM -0.358161392903945 0.394419666661341 no 2052 0.360111268656273 2996 3598955
SGTC_1779 st039427 55 µM -0.359265900102249 0.393944096469441 no 2053 0.359698090767974 3245 1124498
SGTC_1360 1598-0022 39.8 µM -0.360223879540784 0.393531745076828 no 2054 0.359339859221402 3147 761525
SGTC_707 0865-0008 204 µM -0.36079478307772 0.393286062859367 no 2055 0.359126431502047 3030 723043
SGTC_448 monastrol 171 µM -0.361119578803061 0.393146309456876 no 2056 0.359005028832624 3085 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3330 9141424 71.43 µM -0.363732735669674 0.392022420420197 no 2057 0.358028797912627 3172 27261020
SGTC_1842 st055362 61.2 µM -0.364395400342742 0.391737558614188 no 2058 0.357781384859891 3049 676032
SGTC_3138 9097216 49.47 µM -0.364461829791366 0.391709005570253 no 2059 0.357756585996517 3070 25237486
SGTC_1159 4092-0538 61.2 µM -0.365150833316487 0.391412888994639 no 2060 0.357499408625315 3067 717301
SGTC_3280 9140961 49.47 µM -0.365953649387626 0.391067937992651 no 2061 0.35719983121224 3029 4901226
SGTC_1440 4100-1550 40 µM -0.366085121458679 0.391011455722936 no 2062 0.357150779709985 3089 742806
SGTC_1581 himbacine 57.9 µM -0.367039428549926 0.390601540810761 no 2063 0.356794803820835 3041 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_827 3253-0474 693 µM -0.368044958111106 0.390169755220263 no 2064 0.356419855799466 3182 5402065
SGTC_819 1013-0258 27.7 µM -0.368620378053373 0.389922724393145 no 2065 0.356205352078304 3071 5753198
SGTC_2487 5918373 44.05 µM -0.368624310852211 0.389921036174625 no 2066 0.356203886175068 3193 2876279
SGTC_687 k029-0044 34.9 µM -0.370800855735174 0.388987037952961 no 2067 0.355392931972931 3180 5829338
SGTC_2061 5245884 80.95 µM -0.371031877723149 0.388887939420447 no 2068 0.355306894332378 3036 573863
SGTC_3128 9127691 49.47 µM -0.371070182944155 0.388871508820696 no 2069 0.355292629343018 3159 41316314
SGTC_157 1348-1695 65.819 µM -0.372896619681263 0.388088310224552 no 2070 0.354612693985544 3105 5380510
SGTC_1353 1498-1206 8.11 µM -0.372957334663758 0.388062282687045 no 2071 0.354590099300633 3108 6756808
SGTC_331 k048-0133 24.5 µM -0.376819409471776 0.386407711211482 no 2072 0.353153907768007 3062 6813582
SGTC_2134 5324836 1.464 µM -0.377024827800231 0.386319764407478 no 2073 0.353077577095979 3049 699272
SGTC_1989 st071868 50.2 µM -0.378825749830633 0.38554897691686 no 2074 0.352408632232209 3186 16414057
SGTC_495 decylubiquinone 155 µM -0.379355647852715 0.385322268549403 no 2075 0.352211890639674 3127 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2286 7945697 125 µM -0.379769333296885 0.385145307100286 no 2076 0.352058324169014 3119 1245733
SGTC_1157 4092-0394 27.6 µM -0.380149203210332 0.384982831919665 no 2077 0.351917331795556 3260 3659885
SGTC_143 4032-1194 15.74 µM -0.381717511687492 0.384312260555534 no 2078 0.351335454739098 3017 1806963
SGTC_1503 4585-0012 61.3 µM -0.381917280112744 0.384226869141693 no 2079 0.351261361223073 3239 2922052
SGTC_646 4092-0839 27.3 µM -0.382573128258337 0.383946565062195 no 2080 0.351018148848716 3225 877796
SGTC_128 0906-2981 13.371 µM -0.382612844396671 0.383929592660562 no 2081 0.351003422616877 3245 6740226
SGTC_2264 7948757 110.76 µM -0.382782180589921 0.383857230573689 no 2082 0.350940637451793 3016 2971411
SGTC_1109 tnp00067 928.257 nM -0.383185361358821 0.383684956468693 no 2083 0.350791165584566 3105 676295
SGTC_2528 xanthyletin 44.79 µM -0.383311262319587 0.383631165269711 no 2084 0.350744494845111 3053 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2873 9040596 71.43 µM -0.383462555390745 0.383566528255528 no 2085 0.350688414380392 3193 6463863
SGTC_2387 9077560 195.08 µM -0.38355202684574 0.383528304845731 no 2086 0.350655251135498 3072 5303272
SGTC_1737 st035557 69.7 µM -0.384844360772752 0.382976328999321 no 2087 0.350176365223354 3106 5716916
SGTC_511 blebbistatin 171 µM -0.385128686240568 0.382854921027909 no 2088 0.350071037807187 3237 3476986 A myosin inhibitor.
SGTC_1633 st005664 67.9 µM -0.385479335410715 0.382705208453127 no 2089 0.349941156880725 3027 2063822
SGTC_488 nitrendipine 139 µM -0.387088102606691 0.382018556913095 no 2090 0.349345492572505 3114 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2942 9052777 62.25 µM -0.390692314340596 0.380481562201987 no 2091 0.348012340259507 3104 6469503
SGTC_9 0092-0002 10.449 µM -0.390810674273295 0.380431120144878 no 2092 0.347968592151773 3170 759368
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.390840255799598 0.380418513552229 no 2093 0.347957658566718 3222 688664
SGTC_904 1141-0088 396 µM -0.390898526974582 0.38039368082491 no 2094 0.347936121411968 3113 1378119
SGTC_767 0929-0023 86 µM -0.39179569710082 0.380011406874469 no 2095 0.347604587314395 3198 1204563
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.392011879360871 0.37991931158964 no 2096 0.347524718216041 3328 6710655
SGTC_1771 st048882 4.1505 µM -0.392260235162863 0.379813518536814 no 2097 0.347432970873319 3078 4580403
SGTC_3153 9100258 49.47 µM -0.393258466457627 0.379388389011925 no 2098 0.347064295508898 3090 25236848
SGTC_3317 9138495 8.753 µM -0.393652097321846 0.379220788455107 no 2099 0.346918956136181 3109 17020139
SGTC_1770 st043884 66.3 µM -0.393679677822858 0.379209046051432 no 2100 0.346908773498425 3077 670149
SGTC_760 0568-0725 82.9 µM -0.394587985684118 0.378822396134631 no 2101 0.346573490792415 3217 3916171
SGTC_2880 9042983 58.44 µM -0.394589831636134 0.378821610470198 no 2102 0.346572809520384 3214 6464714
SGTC_1979 st071809 45.3 µM -0.394961796499657 0.378663306952688 no 2103 0.346435541291444 3219 4976333
SGTC_391 gliotoxin 8.33 µM -0.395904549002046 0.378262174707353 no 2104 0.346087722535106 3261 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2620 irigenin 100 µM -0.396017317716016 0.378214201464814 no 2105 0.346046126374156 3266 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_485 niflumic acid 177 µM -0.396057451431002 0.378197128525906 no 2106 0.346031322995896 3203 4488 A COX2 inhibitor.
SGTC_2822 7994718 71.43 µM -0.397521126707213 0.37757464175285 no 2107 0.345491605209222 3125 1018011
SGTC_2183 6420625 130.508 µM -0.397677617561278 0.377508106504839 no 2108 0.345433919099987 3170 2897619
SGTC_296 1222-0039 74.9 µM -0.397717559126424 0.377491125123744 no 2109 0.345419196300239 3136 5984176
SGTC_863 0466-0191 129 µM -0.398462763854704 0.377174340604304 no 2110 0.345144550424658 3209 765160 YPR165W RHO1
SGTC_2403 6032726 181.2 µM -0.399165315251865 0.376875763576917 no 2111 0.34488569914365 3158 2881040
SGTC_2945 9067681 61.76 µM -0.40161647981727 0.375834621720924 no 2112 0.343983149816718 3172 16456930
SGTC_3046 9092212 49.47 µM -0.402131454932617 0.375615998573017 no 2113 0.343793642299111 3176 25236637
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.402804121654632 0.375330490527529 no 2114 0.34354616439908 3180 676296 Flavone; oxidizing agent.
SGTC_2030 5175110 200 µM -0.402872027989154 0.375301672015062 no 2115 0.343521184997923 3240 2831986
SGTC_859 0439-0102 54.6 µM -0.404586636567986 0.374574246798765 no 2116 0.342890691541455 3247 610143
SGTC_2080 5212524 12.4 µM -0.40481321849261 0.374478152401947 no 2117 0.342807405828029 3227 260183
SGTC_830 4076-0286 57.8 µM -0.405085361956352 0.374362745460071 no 2118 0.342707382957226 3116 6866659
SGTC_3171 9103192 49.47 µM -0.406135801185245 0.373917394968938 no 2119 0.342321410842444 3227 13018434
SGTC_1547 harmine 94.2 µM -0.407344592537337 0.373405116803931 no 2120 0.341877457763444 3153 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2664 lyso-paf C-16 73.48 µM -0.407647315786919 0.37327685957996 no 2121 0.34176631072363 3110 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_809 3998-0021 90 µM -0.408223672325501 0.37303270873301 no 2122 0.341554735155373 3257 715485
SGTC_1033 k072-0102 21.3 µM -0.408402062445182 0.372957151081334 no 2123 0.341489259748633 3273 5965931
SGTC_577 r071-0003 38.6 µM -0.408856557565633 0.372764670447992 no 2124 0.341322465721521 3126 4568517 YMR134W ERG29
SGTC_2440 5628896 157.78 µM -0.409482779071736 0.372499514996289 no 2125 0.341092701031905 3108 5522048
SGTC_3279 9140807 49.47 µM -0.41247611250767 0.371232910856839 no 2126 0.339995242883126 3177 45595718
SGTC_1211 1056-0033 32.3 µM -0.413224788136787 0.370916332295479 no 2127 0.339720964244754 3257 6741922
SGTC_2189 6047310 154.431 µM -0.413878877763743 0.370639821046614 no 2128 0.339481406790857 3119 711535
SGTC_3027 9089541 49.47 µM -0.413919687672255 0.370622571191226 no 2129 0.339466462489213 3232 9943819
SGTC_1035 k081-0041 55.2 µM -0.414746666308936 0.370273073390115 no 2130 0.339163683141518 3282 731709
SGTC_2301 7769476 200 µM -0.416422688519378 0.369565081360986 no 2131 0.338550364510229 3184 977820
SGTC_3166 9102297 49.47 µM -0.416607338840541 0.369487107620522 no 2132 0.338482820258252 3181 25237072
SGTC_955 1216-0110 33 µM -0.417517301635 0.369102928950051 no 2133 0.338150035915015 3147 3619719
SGTC_1100 amiodarone 5.07 µM -0.417802880981415 0.368982386673156 no 2134 0.338045622162126 3229 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_928 2764-0428 58.7 µM -0.417853325688442 0.368961095436205 no 2135 0.338027179821707 3230 662578
SGTC_1656 st012921 11 µM -0.41787018354542 0.368953980316962 no 2136 0.338021016757554 3220 6732821
SGTC_3163 9099914 49.47 µM -0.418324136405529 0.368762399386096 no 2137 0.337855072455474 3220 16268368
SGTC_3110 9122132 49.47 µM -0.418513450278839 0.368682513215962 no 2138 0.337785877312965 3306 918317
SGTC_457 grayanotoxin iii 135 µM -0.418822337016653 0.36855218218662 no 2139 0.337672989476699 3233 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2998 9066762 71.4286 µM -0.419021062536994 0.368468340344814 no 2140 0.337600369623244 3327 4945196
SGTC_2906 7926292 26.41 µM -0.419103318054897 0.368433638762393 no 2141 0.337570312929754 3254 2966319
SGTC_1038 k292-0204 154 µM -0.419225341994512 0.368382161836552 no 2142 0.337525726508774 3078 4454212
SGTC_204 PMA1.184 62.41 µM -0.4193786257568 0.368317501013634 no 2143 0.337469721269307 3165 2252213 YGL008C PMA1
SGTC_1608 st001473 40.5 µM -0.42033439934922 0.367914404165502 no 2144 0.337120591827501 3148 7292267
SGTC_3197 9113331 49.47 µM -0.420651036176219 0.367780894849418 no 2145 0.337004960159719 3334 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1817 st052116 64.4 µM -0.4208294562696 0.367705671391783 no 2146 0.336939810235971 3270 4361398
SGTC_1620 st003704 16.5 µM -0.420880155126798 0.367684297239946 no 2147 0.336921298489909 3272 2834414
SGTC_3329 9141233 27.5565 µM -0.421135323659827 0.367576726857197 no 2148 0.336828134437182 3281 4909101 YNL103W MET4
SGTC_2165 5727197 32.143 µM -0.42137383131824 0.36747618952615 no 2149 0.33674106245344 3452 1361712
SGTC_1188 1403-0014 4.57 µM -0.422341372853299 0.367068438219159 no 2150 0.336387931885008 3165 9614867
SGTC_2911 7942208 15.64 µM -0.422369211472095 0.367056708398415 no 2151 0.336377773558728 3226 1243384
SGTC_543 3844-1095 191 µM -0.422997250491323 0.366792116734414 no 2152 0.336148633553452 3219 4230703
SGTC_591 4299-0174 154 µM -0.424382385719537 0.366208785686302 no 2153 0.335643482287089 3173 5509088
SGTC_759 3486-0358 89.3 µM -0.425284489275675 0.365829043010843 no 2154 0.335314649612038 3317 875103
SGTC_2377 9073351 62.6 µM -0.426801855723309 0.3651906005324 no 2155 0.334761827370061 3131 7337946 YHR072W ERG7
SGTC_1837 st055472 66.5 µM -0.428046614412193 0.36466713841094 no 2156 0.334308591514886 3329 676091
SGTC_2026 5148700 152 µM -0.428239921349826 0.364585869063289 no 2157 0.334238227117754 3130 79838
SGTC_1753 st043925 64 µM -0.428368666295072 0.364531745992333 no 2158 0.334191366741577 3243 670181
SGTC_2643 anethole 100 µM -0.428471883554035 0.364488356452401 no 2159 0.334153799757653 3215 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1310 1188-0297 994 nM -0.428981754824115 0.364274046849686 no 2160 0.333968251240201 3167 1588352
SGTC_1429 4049-0205 9.46 µM -0.429285489430167 0.364146400977182 no 2161 0.333857737711566 3221 22774478
SGTC_1177 0983-0204 23.6 µM -0.429658342085158 0.363989728529257 no 2162 0.333722095351902 3292 766818
SGTC_1917 st066507 28.5 µM -0.429799003560667 0.363930628571073 no 2163 0.333670928892851 3116 3156428
SGTC_1767 st044992 70.3 µM -0.430545543698084 0.363617018419357 no 2164 0.33339942221414 3210 9600693
SGTC_902 1120-0002 2.07 µM -0.431023665992486 0.36341621449879 no 2165 0.33322558134824 3184 3280475
SGTC_171 k064-0041 9.68 µM -0.431537943360345 0.363200267898783 no 2166 0.3330386348187 3163 53325
SGTC_890 0929-0006 47.2 µM -0.433101754943528 0.362543886114126 no 2167 0.332470423948206 3164 1378169
SGTC_2731 amoxapine 43.43 µM -0.43314514494196 0.362525679691413 no 2168 0.332454663674223 3236 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3285 9112818 20.8695 µM -0.433269710786243 0.362473413649816 no 2169 0.332409420058358 3168 17017947 YPR165W RHO1
SGTC_1300 1094-0077 113 µM -0.433669711915203 0.362305596247439 no 2170 0.332264151982349 3176 5532636
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.434174701147046 0.362093769682811 no 2171 0.332080791452447 3288 61125 An anti-inflammatory.
SGTC_1838 st055369 84.5 µM -0.439635640865257 0.3598057928914 no 2172 0.330100511387408 3217 676036
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.439758482766572 0.359754383037217 no 2173 0.330056020122014 3094 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_98 0074-0023 107.663 µM -0.44170931500972 0.358938292195203 no 2174 0.329349784088947 3244 3563821
SGTC_1316 1272-0050 65.9 µM -0.443398210869632 0.358232296532166 no 2175 0.328738864886781 3220 7340392
SGTC_138 0850-0259 40.9225 µM -0.445076729044808 0.357531118872418 no 2176 0.328132152681461 3287 6813004
SGTC_629 3448-6466 76.7 µM -0.445497335976386 0.357355491382968 no 2177 0.327980192285567 3228 573744
SGTC_1471 k673-0312 37 µM -0.44834142889052 0.356168714131608 no 2178 0.326953402818938 3246 24099884
SGTC_2401 5128683 200 µM -0.448787791038577 0.355982583132404 no 2179 0.326792373416974 3180 708373
SGTC_36 0335-0881 14.2 µM -0.449180972495454 0.355818656668991 no 2180 0.326650556174796 3228 23828853
SGTC_879 0831-1030 162 µM -0.450332346527937 0.355338775565247 no 2181 0.326235409365365 3226 1549252
SGTC_1337 1486-1011 40.3 µM -0.451096885685869 0.355020249963759 no 2182 0.325959861085109 3290 X1337
SGTC_2291 7917025 104.35 µM -0.452061854496474 0.3546183651235 no 2183 0.325612211423783 3141 2964612
SGTC_1156 4092-0367 4.88 µM -0.452195618320739 0.354562668667239 no 2184 0.325564032242292 3230 1357585
SGTC_1553 gossypol 38.6 µM -0.457803516522668 0.352230468180066 no 2185 0.323546804585098 3230 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1638 st008370 60.6 µM -0.461727581992701 0.350601828636819 no 2186 0.322138344447302 3278 24207134
SGTC_617 3770-0098 35 µM -0.462434419350872 0.350308754281726 no 2187 0.321884910653815 3236 5962639
SGTC_2712 st079126 47.7 µM -0.462611476080719 0.350235355604517 no 2188 0.3218214406181 3185 3152970
SGTC_3008 9078912 71.4286 µM -0.463090863874911 0.350036653990188 no 2189 0.321649619191925 3229 16648731
SGTC_532 1548-0774 215 µM -0.464245782664365 0.349558119976178 no 2190 0.321235831684699 3428 5932993
SGTC_406 estrone 100 µM -0.464859797467263 0.349303803689553 no 2191 0.321015931036796 3365 5870 A steroid.
SGTC_1030 k029-0042 36.7 µM -0.465810407514207 0.348910207854262 no 2192 0.320675607415698 3261 6080581
SGTC_1729 st035615 45.989 µM -0.466566894455107 0.348597103921594 no 2193 0.320404888576241 3281 17385451
SGTC_3151 9099821 49.47 µM -0.466605171464508 0.348581264110434 no 2194 0.320391193181269 3299 17174189
SGTC_1484 3473-2379 286 µM -0.467697576520596 0.348129315876916 no 2195 0.320000437213095 3376 671917
SGTC_2318 6029776 164 µM -0.468132675690958 0.347949367283519 no 2196 0.319844856732012 3370 818325
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.468301161272908 0.347879694102667 no 2197 0.319784619049998 3241 688761
SGTC_748 act1.228 77.9 µM -0.468335584564051 0.347865459806104 no 2198 0.31977231247317 3248 4421505 YNR035C ARC35
SGTC_2719 novobiocin 32.65 µM -0.468551998028302 0.347775976080279 no 2199 0.319694947631394 3337 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_518 1021-0119 62.6 µM -0.468605015269166 0.347754055538162 no 2200 0.319675995891956 3219 1097762
SGTC_347 4534-1311 26.2 µM -0.469788686228171 0.347264786832683 no 2201 0.319252999161555 3265 2862016
SGTC_1571 st070080 73.4 µM -0.469864898620915 0.347233293258381 no 2202 0.319225771948774 3385 4315245
SGTC_2086 5274770 176.623 µM -0.470844184493991 0.346828712680391 no 2203 0.31887600455533 3283 689278
SGTC_433 pimozide 108 µM -0.470902277505898 0.346804717708865 no 2204 0.318855260783549 3145 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3219 9131112 49.47 µM -0.471013748860903 0.346758676852336 no 2205 0.318815458336525 3308 17612988 YMR079W SEC14
SGTC_286 k060-0067 22.9 µM -0.471078683808942 0.346731857905352 no 2206 0.318792273344658 3249 5985051
SGTC_2941 9056145 11.23 µM -0.471137863076352 0.346707416795484 no 2207 0.318771144033479 3290 2119517
SGTC_2768 sulfasalazine 50.2 µM -0.471222585188272 0.34667242757006 no 2208 0.318740895954005 3393 5384001 An antioxidant and salicylic acid derivative.
SGTC_2775 cyproheptadine 69.59 µM -0.471602525646848 0.346515532763151 no 2209 0.318605261813711 3338 2913 A selective serotonin reuptake inhibitor.
SGTC_1572 epiandrosterone 68.9 µM -0.472148647812938 0.346290060044974 no 2210 0.31841034538995 3262 441302 A steroid.
SGTC_135 0933-0004 26.348 µM -0.472979830465116 0.345947001426974 no 2211 0.318113784507893 3350 21230617 YGL099W LSG1
SGTC_2802 7925815 54.55 µM -0.473282325548554 0.345822182316633 no 2212 0.318005885035811 3205 1262923
SGTC_709 3807-1509 243 µM -0.473651765860583 0.345669762199785 no 2213 0.317874127269778 3301 1886677 YPL242C IQG1
SGTC_1616 st002734 56.1 µM -0.473653171129955 0.345669182475055 no 2214 0.317873626136333 3205 4026101
SGTC_2140 5586273 200 µM -0.473909593533299 0.345563404966078 no 2215 0.317782188866341 3316 854421
SGTC_2062 5245942 200 µM -0.477137418543295 0.344232919610858 no 2216 0.316632135476388 3342 1376160
SGTC_3188 9110789 49.47 µM -0.477630411495097 0.344029880708072 no 2217 0.316456640812858 3387 849217
SGTC_2097 5376186 200 µM -0.480211154312092 0.342967737968691 no 2218 0.315538628094607 3322 742755
SGTC_460 trequinsin 123 µM -0.480794560487506 0.342727800066615 no 2219 0.315331258309611 3352 5537 A vasodilator.
SGTC_2728 chlorpromazine 9.18 µM -0.481008801722733 0.342639704829106 no 2220 0.315255121572256 3259 2726 A thorazine and dopamine antagonist.
SGTC_1104 tacrolimus 29.8 µM -0.481244107264447 0.342542957884758 no 2221 0.315171508073154 3337 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1414 3917-0015 5.4 µM -0.481678290068059 0.342364468766186 no 2222 0.315017250359387 3330 6618702
SGTC_3104 9120930 49.47 µM -0.483025922536388 0.341810692064705 no 2223 0.314538665166699 3347 17014836
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.483030096104014 0.341808977566716 no 2224 0.314537183489552 3281 2333 A French combination drug.
SGTC_1504 k297-0033 30 µM -0.48392724554347 0.34144050513401 no 2225 0.314218751768355 3175 4388117
SGTC_1076 itraconazole 331 nM -0.484568806577525 0.341177099236317 no 2226 0.313991122634079 3322 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1468 k284-1086 134 µM -0.484904121635254 0.341039459616328 no 2227 0.313872179287083 3290 15996457
SGTC_2303 7774051 200 µM -0.485363151079119 0.340851072201071 no 2228 0.313709383187756 3397 2953184
SGTC_1419 3993-2473 62.6 µM -0.485430342756164 0.340823499811545 no 2229 0.313685556510357 3303 704026
SGTC_2459 5811157 9.22 µM -0.486202789154543 0.340506584267065 no 2230 0.313411697010926 3335 2870684 YBR192W RIM2
SGTC_2936 9038235 15.59 µM -0.486270287750007 0.340478896617775 no 2231 0.313387771261263 3274 4749415
SGTC_1217 1183-1422 255 µM -0.486505917815156 0.340382248863506 no 2232 0.313304255294993 3364 2849664
SGTC_2740 felodipine 17.08 µM -0.488081529885222 0.339736253944897 no 2233 0.312746046602721 3314 3333 L-type calcium channel blocker
SGTC_1235 benzylparaben 21.5 µM -0.489385791211268 0.339201867560986 no 2234 0.312284296776288 3330 7180
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.489862495634178 0.339006631220797 no 2235 0.312115601801873 3342 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2556 citropten 84.59 µM -0.493145936626949 0.33766306064136 no 2236 0.310954737419873 3275 2775 A potential DNA crosslinker.
SGTC_597 k018-0003 82.8 µM -0.494043768966957 0.337296030378848 no 2237 0.310637634354267 3386 6786234
SGTC_64 000l-0018 272.079 µM -0.494252543736841 0.337210706257209 no 2238 0.310563917881889 3299 6811119
SGTC_2184 6075246 200 µM -0.494334321906358 0.337177286634265 no 2239 0.310535044827116 3316 2267320
SGTC_3341 9147222 25.867 µM -0.495168834724142 0.336836326525778 no 2240 0.310240473849222 3374 1939759
SGTC_1756 st041558 35.5 µM -0.496090766909592 0.33645980499721 no 2241 0.309915186592225 3422 3955792
SGTC_121 0557-0495 61.343 µM -0.496982200667134 0.336095895047576 no 2242 0.309600801597716 3320 3104427
SGTC_2656 pseudo-anisatin 100 µM -0.499673143942958 0.33499830402885 no 2243 0.308652622812192 3307 6708809 A neurotoxin.
SGTC_1202 1988-0068 29.6 µM -0.500326702305338 0.334731940547934 no 2244 0.308422527568008 3270 2850480
SGTC_2242 6630449 61.2675 µM -0.500806884218806 0.334536291142104 no 2245 0.308253520097044 3376 691249 YDR170C SEC7
SGTC_317 4495-0002 170 µM -0.501027064432361 0.334446594061256 no 2246 0.308176037843683 3310 15991618
SGTC_1569 carminic acid 40.6 µM -0.501694464475056 0.334174766185714 no 2247 0.307941229464186 3394 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1524 corynanthine 62.1 µM -0.501695198846991 0.334174467128471 no 2248 0.307940971136665 3394 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2774 tamoxifen 10.92 µM -0.501871478348596 0.334102684122531 no 2249 0.307878964649017 3376 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2943 9068529 45.32 µM -0.502069281638758 0.334022143611381 no 2250 0.307809393678698 3372 3270634
SGTC_953 1188-0045 9.7 µM -0.502731994733831 0.333752359275168 no 2251 0.307576355939427 3378 6144426
SGTC_1024 4507-0395 26 µM -0.503615919812549 0.333392655345967 no 2252 0.307265651615413 3439 4201836
SGTC_235 0330-0087 5 mM -0.50565085483354 0.3325651427021 no 2253 0.306550887144552 3344 46494818 YHR062C RPP1
SGTC_397 arbidol 50 µM -0.506764094536524 0.332112785034655 no 2254 0.306160176158982 3399 131410 A RNA synthesis inhibitor.
SGTC_536 3852-0578 10.6 µM -0.507913567150713 0.331645960953588 no 2255 0.305756979834405 3413 2869208
SGTC_2260 7964312 200 µM -0.508251223555444 0.331508881485181 no 2256 0.305638586025974 3411 231951
SGTC_193 1273-0060 1.558 µM -0.509168299296508 0.331136687180659 no 2257 0.305317130662544 3342 2847393 YHR072W ERG7
SGTC_2814 7977482 42.97 µM -0.510125492560865 0.330748389096468 no 2258 0.304981773279426 3398 6456762
SGTC_1238 0333-0287 48.8 µM -0.510565628174527 0.330569903350263 no 2259 0.304827624527528 3316 7226
SGTC_2813 7971799 71.43 µM -0.51080997480012 0.330470831451066 no 2260 0.304742061928232 3368 2234054
SGTC_789 1309-1135 70.6 µM -0.511858959824491 0.330045648819516 no 2261 0.304374861326886 3388 3092424
SGTC_2011 4012611 177 µM -0.513334913507019 0.329447775641581 no 2262 0.303858532814712 3284 2049887
SGTC_1420 4'-methoxyflavone 42 µM -0.52042063838991 0.3265836093504 no 2263 0.301385214252543 3399 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2830 7992007 71.43 µM -0.520995354731781 0.32635174422743 no 2264 0.301185003685381 3319 1952075
SGTC_864 0469-0573 172 µM -0.52137993114784 0.326196627133382 no 2265 0.301051064521857 3323 689425
SGTC_2089 5281248 129.67 µM -0.521604906158994 0.326105898453138 no 2266 0.300972723323233 3380 2737878
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.524071269529487 0.325111931029249 no 2267 0.300114485302353 3322 5106787 A p450 inhibitor.
SGTC_2736 butenafine 14.65 µM -0.525837120488992 0.32440103985585 no 2268 0.299500690359878 3313 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2722 naftopidil 47.16 µM -0.525995153968513 0.324337450333291 no 2269 0.299445787003622 3390 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_336 4111-0029 111 µM -0.527937987048371 0.323556112101213 no 2270 0.298771188970365 3350 3131175
SGTC_1307 1187-1599 12.2 µM -0.527983137877317 0.323537963275501 no 2271 0.29875551974018 3302 1538471
SGTC_1458 k015-0034 6.33 µM -0.528468395962209 0.323342935457468 no 2272 0.298587138429742 3359 3598957
SGTC_2179 6298986 200 µM -0.52854341518887 0.323312789159426 no 2273 0.298561111112316 3421 738374
SGTC_909 3448-9333 149 µM -0.528680692036385 0.323257627788046 no 2274 0.298513486686063 3325 3344074
SGTC_1078 idebenone 36.1 µM -0.529683400904259 0.322854831456544 no 2275 0.298165729288937 3387 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2904 7225135 42.03 µM -0.531989405742128 0.321929279246846 no 2276 0.297366666551293 3463 4446116
SGTC_2502 avocadyne acetate 18.59 µM -0.533336879835939 0.32138895922547 no 2277 0.296900201323978 3349 3952079
SGTC_999 SEC7.066 22.7 µM -0.53446105199363 0.320938469408339 no 2278 0.296511294588555 3351 740511 YDR170C SEC7
SGTC_3047 9092122 49.47 µM -0.534727974259673 0.320831544257518 no 2279 0.296418987282349 3367 17173831
SGTC_540 1187-0821 17.3 µM -0.536007505779323 0.320319189152119 no 2280 0.295976681526053 3331 847520
SGTC_163 TUB2.036 7.546 µM -0.536174834179723 0.320252212138435 no 2281 0.295918862207804 3398 15992207 YJR013W GPI14
SGTC_1403 3909-7815 62.9 µM -0.536288897570921 0.320206559017319 no 2282 0.2958794512649 3336 6615483
SGTC_3244 9134489 49.47 µM -0.538746409504199 0.319223617997746 no 2283 0.29503092301182 3405 16584271
SGTC_2645 abamectin 100 µM -0.539979042339662 0.318731074404365 no 2284 0.294605742835142 3410 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2404 5161160 200 µM -0.539998495673099 0.318723303675705 no 2285 0.294599034934904 3390 2831543
SGTC_743 1275-0778 158 µM -0.54212191768766 0.31787557225135 no 2286 0.293867260377804 3418 2849257 YMR203W TOM40
SGTC_2900 5328528 85.29 µM -0.542810728768136 0.317600783589049 no 2287 0.293630062757045 3432 795359
SGTC_2868 9035608 32.47 µM -0.54366950091712 0.317258332752743 no 2288 0.293334461876097 3406 6462614
SGTC_1062 mesoridazine 14.2 µM -0.543791133774432 0.317209842101711 no 2289 0.293292605368686 3419 4078 A neuroleptic.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.543891388806603 0.317169876380741 no 2290 0.293258107516421 3434 616764
SGTC_2471 5466956 24.79 µM -0.544063968429654 0.317101084139797 no 2291 0.293198727109545 3327 724419
SGTC_479 n-linoleoylglycine 10 µM -0.545238174059415 0.316633200039304 no 2292 0.292794859885797 3387 6433346 An anti-infammatory.
SGTC_378 3970-0959 8.33 µM -0.546259425622948 0.316226501714825 no 2293 0.292443811264112 3436 6615653
SGTC_2939 9044578 71.43 µM -0.547487782809659 0.315737621041413 no 2294 0.292021830813118 3382 2653634
SGTC_637 1181-0519 7.26 µM -0.547882254241856 0.315580691483618 no 2295 0.291886377267476 3444 6252091 YGR060W ERG25
SGTC_201 4262-0159 12.803 µM -0.548444579932551 0.315357043235293 no 2296 0.291693336558402 3371 1341029
SGTC_3254 9136651 49.47 µM -0.548485931833337 0.315340599420678 no 2297 0.291679143219163 3387 16454030
SGTC_1516 st013856 110 µM -0.548948831236136 0.315156549855204 no 2298 0.291520282818063 3414 5281404 A mutagen and neurotoxin.
SGTC_1372 2752-0194 270 µM -0.548950430919026 0.315155913898165 no 2299 0.291519733899928 3433 823334
SGTC_2907 7721985 69.9 µM -0.55032393879458 0.314610075512318 no 2300 0.291048603867198 3403 3267881
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.550615513190269 0.314494254560209 no 2301 0.290948636061143 3443 229346 A bile salt which induces apoptosis.
SGTC_3345 9148410 3.559 µM -0.551103815870242 0.314300328893238 no 2302 0.290781254879821 3450 4903596
SGTC_2516 gossypol 71.55 µM -0.551656233514982 0.314081002237378 no 2303 0.290591950564319 3489 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1407 3909-7909 12.3 µM -0.552501826895179 0.313745403042389 no 2304 0.290302291548318 3448 4411780
SGTC_1071 trifluoperazine 6.31 µM -0.552746381041997 0.313648373072859 no 2305 0.290218544451211 3500 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2486 5283202 22.39 µM -0.552751140184288 0.313646484950445 no 2306 0.290216914804366 3359 1377751
SGTC_1806 st050005 60.3 µM -0.552766239384585 0.313640494588528 no 2307 0.290211744496868 3373 5194765
SGTC_1563 conessine 56.1 µM -0.552968472653157 0.313560266568538 no 2308 0.290142499414141 3477 441082 An anti-amoebic, histamine inhibitor.
SGTC_2198 6589944 200 µM -0.553036816952902 0.313533155674556 no 2309 0.29011909993728 3421 5290268
SGTC_3267 9137951 49.47 µM -0.553258944902274 0.31344504866619 no 2310 0.290043054673379 3383 16643986
SGTC_3147 9097027 49.47 µM -0.553541393583871 0.313333030823679 no 2311 0.289946372168269 3376 25236841
SGTC_2967 9089538 49.85 µM -0.554617316567956 0.312906482529618 no 2312 0.289578221002806 3488 728216
SGTC_2463 5473429 200 µM -0.554727917920192 0.312862648945257 no 2313 0.289540388714512 3385 5399405
SGTC_2018 5133068 143 µM -0.557211972098942 0.311878865278628 no 2314 0.288691305451649 3422 785362
SGTC_119 0121-0043 24.815 µM -0.559094950236131 0.311134024267366 no 2315 0.288048460450166 3512 1092378
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.560329744446288 0.310646001720537 no 2316 0.287627271278763 3490 551469
SGTC_1166 k206-0078 225 µM -0.561385396554436 0.31022904474918 no 2317 0.287267418573844 3455 5404595
SGTC_1200 1643-0193 18.4 µM -0.561788349115716 0.310069952533632 no 2318 0.287130115541871 3479 5403974
SGTC_3174 9107204 49.47 µM -0.562855337343164 0.309648860003625 no 2319 0.286766697528184 3489 3938802
SGTC_1871 st057448 67.3 µM -0.563298953159615 0.309473858145545 no 2320 0.286615665422439 3562 691747
SGTC_1587 estradiol valerate 56.1 µM -0.564031452148412 0.30918498942178 no 2321 0.286366363629696 3491 13791 A steroid.
SGTC_815 1582-0027 36.9 µM -0.56443623425947 0.309025409890152 no 2322 0.286228642550833 3460 3128206
SGTC_1933 st074711 15.9 µM -0.564991728715086 0.308806472841474 no 2323 0.28603969506084 3456 17250958
SGTC_2201 6605497 169.863 µM -0.565570531572923 0.308578421510899 no 2324 0.285842882459943 3428 670741
SGTC_2655 perillic acid 100 µM -0.565964470340945 0.308423249803284 no 2325 0.285708966757475 3389 5702197 An apoptosis inducer.
SGTC_1696 st025591 34.7925 µM -0.566486215739473 0.308217787986318 no 2326 0.285531650373653 3462 2787147
SGTC_1313 1220-0047 237 µM -0.569903280003554 0.306873645476135 no 2327 0.284371650052799 3452 3528706
SGTC_1152 3909-8331 15.9 µM -0.571171111503608 0.306375587325143 no 2328 0.283941829279496 3417 16001939
SGTC_2300 7976697 71.57 µM -0.571597881807895 0.30620801417503 no 2329 0.283797215401587 3370 2236109
SGTC_1408 3909-7976 48.8 µM -0.571935114446591 0.306075627033275 no 2330 0.283682966888613 3468 24152374
SGTC_54 0159-0055 9 µM -0.574330074199837 0.305136168989509 no 2331 0.282872230848801 3576 3319099
SGTC_1127 asiatic acid 681.4 nM -0.575017663753132 0.304866688602891 no 2332 0.282639675441837 3403 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_177 1327-0068 8.361 µM -0.57578813902446 0.304564849323048 no 2333 0.282379195786218 3471 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2511 berberine 10.47 µM -0.576186649912665 0.304408781972807 no 2334 0.28224451390747 3445 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_231 b-estradiol 524 µM -0.581163540186073 0.302462707395716 no 2335 0.280565118922733 3402 450 A steroid.
SGTC_837 0091-0265 12.5 µM -0.581961032553508 0.302151389418247 no 2336 0.280296464369179 3424 759367
SGTC_255 tunicamycin 200.472 nM -0.581963894244248 0.30215027255591 no 2337 0.28029550056397 3441 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2371 9071574 200 µM -0.58366195687822 0.301487878772819 no 2338 0.279723883563529 3486 45596039
SGTC_1953 st076800 12.1 µM -0.585132054414253 0.300914939766117 no 2339 0.279229463490548 3423 297591
SGTC_2158 5657123 3.6195 µM -0.586113822659211 0.300532590289985 no 2340 0.278899513993091 3472 2858827
SGTC_44 0929-0055 61.211 µM -0.586370107370205 0.300432816374846 no 2341 0.278813413888771 3403 1379590
SGTC_1724 st037281 8.293 µM -0.587042811621119 0.300170997848338 no 2342 0.278587477158885 3477 574124 YDL195W SEC31
SGTC_1622 st003707 19.4 µM -0.587116636420967 0.300142271296913 no 2343 0.278562687542238 3499 10140899
SGTC_2929 9013348 24.6 µM -0.587130669912621 0.300136810754679 no 2344 0.278557975360059 3465 2995952
SGTC_3068 9116768 49.47 µM -0.588821071662377 0.29947939103839 no 2345 0.277990654475283 3488 41904888
SGTC_2767 sibutramine 71.45 µM -0.589973268615211 0.299031660791219 no 2346 0.277604285537148 3569 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2495 cafestol 54.53 µM -0.590191967799075 0.298946711181139 no 2347 0.277530978257777 3533 16667697 An anti-infammatory.
SGTC_2273 7815444 169.05 µM -0.590815832365349 0.298704442905984 no 2348 0.277321912813845 3507 2824616
SGTC_2854 9024559 71.43 µM -0.591547446964462 0.29842044531923 no 2349 0.277076837036474 3470 3163529
SGTC_399 oxolinic acid 75 µM -0.591578696547967 0.298408317616975 no 2350 0.277066371432362 3428 4628 A DNA gyrase inhibitor.
SGTC_1520 flindersine 88 µM -0.5915930492961 0.298402747510517 no 2351 0.277061564707378 3585 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1600 coumarin 106 71.1 µM -0.591948542557512 0.298264800510875 no 2352 0.276942523296906 3555 100336 A hepatotoxic, DNA x-linker.
SGTC_1910 st062352 60.4 µM -0.592487063093697 0.298055886219129 no 2353 0.276762240605322 3458 2245730
SGTC_2794 7785382 27.27 µM -0.592769198030394 0.297946461083989 no 2354 0.276667812111447 3509 2205081
SGTC_601 0986-0029 62.9 µM -0.594413654553509 0.297309028640399 no 2355 0.276117738982746 3518 24747981
SGTC_3088 9117578 49.47 µM -0.594558303628503 0.297252988871529 no 2356 0.276069379355724 3545 678341
SGTC_2049 5262831 67.185 µM -0.594732054313916 0.297185680974625 no 2357 0.276011295866156 3493 763417
SGTC_1044 1222-0021 1.78 µM -0.595721460889602 0.296802535484779 no 2358 0.275680659447405 3473 4306703
SGTC_976 1348-1067 47.6 µM -0.595727333627344 0.296800261955362 no 2359 0.275678697497931 3532 5310671 YGL099W LSG1
SGTC_2063 5246145 200 µM -0.596146019951434 0.296638195293421 no 2360 0.275538841513513 3527 711240
SGTC_170 4197-0004 226 µM -0.596536618074744 0.296487037671875 no 2361 0.275408399447172 3520 218692
SGTC_872 0588-0139 234 µM -0.597368288505769 0.296165307066341 no 2362 0.275130760483372 3526 2047100
SGTC_1903 st060211 78.3 µM -0.598832354190508 0.295599324717124 no 2363 0.274642342299835 3549 688960
SGTC_563 tetrahydrosecaminediol 614 µM -0.598910980299224 0.295568943303655 no 2364 0.274616124419175 3549 334274 A psychoactive constituent of the cannabis plant.
SGTC_3172 9105863 49.47 µM -0.598993190735811 0.295537178428306 no 2365 0.274588712664448 3487 2348785
SGTC_407 eburnamonine 100 µM -0.601017770826412 0.294755406986163 no 2366 0.273914075060014 3446 3195
SGTC_1519 esterone 74 µM -0.603223634984877 0.293904721591308 no 2367 0.273179963293976 3443 698 A steroid.
SGTC_441 propafenone 146 µM -0.604368049971654 0.293463828945325 no 2368 0.272799486350831 3497 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2105 5350118 200 µM -0.604993629982724 0.293222950122248 no 2369 0.272591614615082 3523 2133313
SGTC_2333 9017922 200 µM -0.605322802704775 0.293096239381289 no 2370 0.272482266573802 3540 3163164
SGTC_2621 lithochol-11-enic acid 100 µM -0.605922501101125 0.292865458617396 no 2371 0.272283108487049 3539 6708711
SGTC_774 k060-0086 136 µM -0.606302646630165 0.29271921164933 no 2372 0.272156900733418 3569 5911235
SGTC_2772 vinpocetine 57.06 µM -0.606950500555801 0.292470051937559 no 2373 0.271941881215852 3580 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3057 9095946 49.47 µM -0.608662806832331 0.291811986977787 no 2374 0.2713739823407 3523 24540043
SGTC_1183 1254-0324 198 µM -0.609158198929523 0.291621729110273 no 2375 0.271209792220705 3551 5799357
SGTC_692 k241-0027 77.8 µM -0.609374233924054 0.29153877787857 no 2376 0.271138206243148 3593 3600480
SGTC_2838 9002687 71.43 µM -0.609415409290928 0.291522968969105 no 2377 0.271124563324201 3493 6457060
SGTC_914 3820-6779 408 µM -0.609894442359747 0.291339077945749 no 2378 0.270965867148635 3493 2893481
SGTC_2734 clemastine 41.6 µM -0.610067533907626 0.291272644947508 no 2379 0.270908536022137 3469 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1384 3089-0840 101 µM -0.610094138815641 0.291262434539739 no 2380 0.270899724520574 3515 1069836
SGTC_1610 st001799 48.1 µM -0.611165763501535 0.290851306343301 no 2381 0.270544923139827 3458 621897
SGTC_731 3966-0296 387 µM -0.611541791590975 0.290707107704245 no 2382 0.27042048003912 3553 660956
SGTC_1025 k007-0731 70 µM -0.612471944824992 0.290350557778139 no 2383 0.270112777177839 3475 6256118
SGTC_2265 7929201 200 µM -0.613804998354896 0.289839923887492 no 2384 0.269672096950322 3524 1265108
SGTC_454 lyso-paf C-16 6.67 µM -0.61393853497507 0.289788795131985 no 2385 0.269627972328615 3486 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3023 9089636 49.47 µM -0.614050582202344 0.289745897541352 no 2386 0.269590951256691 3618 17249241
SGTC_2649 anisomycin 9.56 µM -0.615172845507087 0.289316400409651 no 2387 0.269220289333933 3515 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3165 9101544 49.47 µM -0.615969457560894 0.289011713704614 no 2388 0.268957338957588 3544 5002184
SGTC_1028 k015-0029 4.8 µM -0.616008815897401 0.288996663914819 no 2389 0.268944350670395 3550 4588309
SGTC_765 1319-0117 244 µM -0.616015654586112 0.288994048983473 no 2390 0.26894209392895 3535 3487746 YGL099W LSG1
SGTC_758 0868-0029 16 µM -0.617234691711755 0.288528099787152 no 2391 0.268539968235036 3547 762687
SGTC_333 3486-0131 40.1 µM -0.6177638723138 0.288325942792261 no 2392 0.26836550072171 3613 6744690
SGTC_374 0880-0231 82.3 µM -0.620081702339383 0.28744127575702 no 2393 0.267601999050511 3538 6833587
SGTC_590 k048-0076 22.4 µM -0.621265059613917 0.286990108715484 no 2394 0.267212619516581 3556 6832814
SGTC_3249 9135183 49.47 µM -0.621930719866574 0.286736466449599 no 2395 0.266993712097517 3593 4902779
SGTC_531 3788-1495 174 µM -0.622994152145823 0.286331478327878 no 2396 0.266644182357469 3523 2896655
SGTC_1768 st044301 37.178 µM -0.623072598944506 0.28630161410234 no 2397 0.266618407568451 3518 3931349
SGTC_2025 5147754 141 µM -0.623414235510898 0.28617157235875 no 2398 0.26650617280431 3554 315777 YLR208W SEC13
SGTC_1829 berberine 14.4 µM -0.624157859840211 0.285888613616439 no 2399 0.266261959287955 3591 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3061 glucosamine 200 µM -0.624299675410808 0.285834666051518 no 2400 0.266215398528997 3510 91431 and experimental redox chemotherapeutic
SGTC_2754 granisetron 64.02 µM -0.625190977643608 0.285495719756666 no 2401 0.265922861380697 3574 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_808 0711-0032 135 µM -0.626003896741956 0.285186748107398 no 2402 0.265656192706317 3549 4252555
SGTC_1399 3562-5772 25 µM -0.626195190693089 0.285114064891951 no 2403 0.265593460661249 3516 23847490
SGTC_2408 sulbentine 18.36 µM -0.626353797521517 0.285053808029647 no 2404 0.265541453576324 3448 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_736 0958-0254 92.6 µM -0.629550186863086 0.283840752873316 no 2405 0.264494461672932 3605 6812352
SGTC_640 3381-0960 37.1 µM -0.630231272103126 0.28358259534942 no 2406 0.264271640896134 3599 1745025
SGTC_768 0384-0033 77.3 µM -0.630390969807421 0.283522080057377 no 2407 0.264219408752095 3515 3965305 YMR134W ERG29
SGTC_305 1682-2595 20.8 µM -0.6314468376722 0.283122128963361 no 2408 0.263874199612299 3564 226033
SGTC_1743 st037606 46.3785 µM -0.631812943039435 0.282983515528038 no 2409 0.263754557548363 3573 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1899 st063254 59.6 µM -0.6321126020808 0.282870084002477 no 2410 0.263656650524609 3515 3093813
SGTC_579 4491-1009 110 µM -0.632940535045043 0.282556795709748 no 2411 0.263386237987068 3698 1271041
SGTC_2630 antimycin a 100 µM -0.633466127178151 0.282357999223425 no 2412 0.263214646988421 3555 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1775 st081588 35.1725 µM -0.634651413877639 0.281909931359533 no 2413 0.262827894031745 3603 1426443 YGL099W LSG1
SGTC_1374 2889-5571 141 µM -0.636944032734683 0.281044237746873 no 2414 0.262080649851677 3544 2853281
SGTC_1442 4112-3290 3 µM -0.64071900929007 0.279621610197292 no 2415 0.260852630692651 3568 704353
SGTC_566 0958-0068 16.5 µM -0.641332067561557 0.279390905050537 no 2416 0.26065347944429 3577 6815365
SGTC_1657 st012939 43.4 µM -0.642118015789616 0.279095273541655 no 2417 0.260398279620818 3601 24207257
SGTC_635 k038-0028 24.7 µM -0.644103082376765 0.27834927603476 no 2418 0.259754295853946 3584 4035102
SGTC_708 3448-5400 146 µM -0.644363467819778 0.278251494091184 no 2419 0.259669884137271 3576 3462195
SGTC_1349 flufenamic acid 69 µM -0.64665491153825 0.277391716453504 no 2420 0.258927655282779 3561 3371 A non-steroidal anti-inflammatory.
SGTC_2442 5158906 48.48 µM -0.648770363682384 0.276599127796079 no 2421 0.258243408000243 3598 1893835
SGTC_1135 dihydrocapsaicin 536.708 nM -0.649149920780444 0.276457038073116 no 2422 0.258120738730286 3562 107982 A Capsaicinoid.
SGTC_1721 st082152 9.2685 µM -0.649525664219996 0.276316411283371 no 2423 0.257999331765458 3571 5296051
SGTC_403 arphamenine a 50 µM -0.649942999531214 0.276160259350573 no 2424 0.257864520722805 3561 5487158 An arginine aminopeptidase inhibitor.
SGTC_2124 5246320 200 µM -0.650699159026192 0.275877441921956 no 2425 0.257620353085851 3597 579342
SGTC_1935 st074532 41.6 µM -0.650752219802966 0.275857601568664 no 2426 0.257603224007743 3671 2829742
SGTC_2153 5569715 200 µM -0.652250215016854 0.275297764382534 no 2427 0.257119885397752 3611 2054701
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.652350091124841 0.275260458149877 no 2428 0.257087676452415 3616 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_973 1325-0077 65.9 µM -0.65463941219283 0.274406022183953 no 2429 0.256349971300083 3626 2835149
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.654878760524122 0.274316766618059 no 2430 0.256272908037322 3568 6708514
SGTC_786 4544-0069 423 µM -0.656014099179251 0.273893581980973 no 2431 0.255907526291889 3595 748821 YLR208W SEC13
SGTC_438 sphingosine 6.67 µM -0.656181905110372 0.273831061606699 no 2432 0.255853545012326 3467 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2986 9022445 71.43 µM -0.657865332182269 0.273204248742344 no 2433 0.255312334510786 3583 6459286
SGTC_68 0986-0284 82.829 µM -0.658680673879957 0.27290091742541 no 2434 0.255050422905041 3582 423278 YIL048W NEO1
SGTC_1981 st071826 47 µM -0.659264500080361 0.272683819407985 no 2435 0.254862967240803 3571 11838600
SGTC_3097 9117246 49.47 µM -0.660020568857447 0.272402799750538 no 2436 0.254620314914294 3635 16423892
SGTC_3299 9121982 43.1275 µM -0.660994957289638 0.272040846162974 no 2437 0.254307773740352 3605 17594604 YPL160W CDC60
SGTC_10 0279-0212 42.575 µM -0.661185221136225 0.271970197255184 no 2438 0.254246768901405 3626 39851 YBR002C RER2
SGTC_1072 oxiconazole 14.9 nM -0.662371757545099 0.271529817715071 no 2439 0.253866499553961 3641 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_67 0335-0847 266 µM -0.662901271873892 0.271333404684109 no 2440 0.253696893552179 3676 4552207 YOR254C SEC63
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.664076653109049 0.270897673071123 no 2441 0.253320626001122 3635 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3037 9091026 49.47 µM -0.667171095830583 0.269752188688991 no 2442 0.252331425754763 3635 25236398 YIL048W NEO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.667673509996612 0.2695664368274 no 2443 0.252171011428512 3655 688788
SGTC_1728 st035614 33.7865 µM -0.66860995779455 0.269220385810758 no 2444 0.251872159407776 3608 15945546
SGTC_1591 genipin 88.4 µM -0.668695847743878 0.269188657556828 no 2445 0.251844758396181 3615 442424 A DNA cross-linking agent.
SGTC_1096 rimcazole 32.2 µM -0.66925147247444 0.268983451832606 no 2446 0.251667538431013 3571 18528119 A dopamine reuptake inhibitor.
SGTC_1242 0402-0103 60.1 µM -0.669798316854983 0.268781565607762 no 2447 0.25149318334686 3594 432868
SGTC_166 k072-0058 166.424 µM -0.670649448468812 0.268467492882597 no 2448 0.251221936793521 3644 5846229
SGTC_1396 3511-0007 98.6 µM -0.671216876113277 0.268258211201476 no 2449 0.251041189651746 3580 X1396
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.674490759476595 0.2670523252956 no 2450 0.249999679274407 3645 442882
SGTC_980 1473-0395 201 µM -0.675179865978509 0.266798852388375 no 2451 0.249780748421446 3587 768876
SGTC_2149 5554786 194.827 µM -0.676669038086655 0.266251508231471 no 2452 0.249307982636511 3673 745063 YPR165W RHO1
SGTC_1486 3970-0793 4.53 µM -0.676961254185461 0.266144171157807 no 2453 0.249215268988746 3664 2844330
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.677300366608819 0.266019635558018 no 2454 0.249107699173413 3698 5024745
SGTC_2267 7931562 200 µM -0.677512642302952 0.265941694485647 no 2455 0.24904037579493 3564 934880
SGTC_1968 st069590 43.6 µM -0.677782664760952 0.265842567308685 no 2456 0.248954751982479 3594 6384066
SGTC_2665 lovastatin 100 µM -0.678352826063246 0.26563331854665 no 2457 0.248774005963991 3637 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2052 5265182 7.135 µM -0.679212981506844 0.265317800285569 no 2458 0.248501461585901 3638 1239884
SGTC_1805 st050013 60.3 µM -0.679602259287449 0.265175069756546 no 2459 0.248378169369136 3602 4037144
SGTC_1435 4092-0789 56.7 µM -0.679657287326623 0.265154896613189 no 2460 0.24836074349692 3654 2248285
SGTC_868 0527-0199 213 µM -0.681157451458199 0.264605240558488 no 2461 0.247885933781608 3607 2849450
SGTC_70 0141-0289 43.283 µM -0.681470801806387 0.264490503065423 no 2462 0.247786817979691 3689 352408
SGTC_140 0062-0056 502.533 µM -0.682901404820316 0.263966990153541 no 2463 0.247334573099321 3630 3758964
SGTC_1783 st039459 87.517 µM -0.683132792930773 0.263882365948763 no 2464 0.247261467737042 3700 729761
SGTC_2644 guaiazulene 100 µM -0.684494634605273 0.263384588044488 no 2465 0.246831438128592 3667 3515 A coloring agent.
SGTC_473 2-arachidonoylglycerol 10 µM -0.684693559861657 0.263311917393221 no 2466 0.246768656902259 3579 5282280 An endocannabinoid.
SGTC_1762 st045503 25.4615 µM -0.684886325206762 0.263241506828058 no 2467 0.246707827914117 3677 4645554
SGTC_2692 st077426 47.7 µM -0.685514067938401 0.263012280621344 no 2468 0.246509793223016 3633 25238571
SGTC_2855 9016525 58.44 µM -0.685622192152105 0.262972808342372 no 2469 0.246475691758563 3671 43811474
SGTC_120 rhodamine 6G 52.259 µM -0.685727566639975 0.262934342803697 no 2470 0.246442459966743 3696 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1731 st035964 63 µM -0.685929976913177 0.262860463727601 no 2471 0.246378632883224 3641 6739575
SGTC_1944 st076371 56.9 µM -0.686584275839763 0.262621719433645 no 2472 0.246172370026907 3650 24208455
SGTC_2684 capsaicin 100 µM -0.68984329925477 0.261434203557886 no 2473 0.245146368012897 3661 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.690358731610882 0.261246644287229 no 2474 0.244984311060714 3696 364106
SGTC_2457 5731572 11.68 µM -0.690544775484682 0.26117896227566 no 2475 0.2449258312148 3694 2865357
SGTC_1280 0880-0253 10.1 µM -0.691022233982987 0.261005306044848 no 2476 0.244775784334857 3638 6836607
SGTC_1250 0485-0349 40.2 µM -0.691113114838407 0.260972258533664 no 2477 0.244747229577095 3658 6842794 YDL195W SEC31
SGTC_338 4055-0136 114 µM -0.691329885767618 0.260893441602062 no 2478 0.244679127408647 3624 2900563
SGTC_2203 7227154 166.4 µM -0.693119922768226 0.260243060524952 no 2479 0.24411714794506 3664 896304
SGTC_2872 9044037 25.97 µM -0.693770921637754 0.260006737933839 no 2480 0.243912940556806 3658 6465195
SGTC_2811 7967822 32.47 µM -0.696269845016336 0.259100619157024 no 2481 0.243129927058387 3683 2232244
SGTC_2023 5144124 124 µM -0.696799340232294 0.258908832095016 no 2482 0.242964189531875 3669 2830192
SGTC_1804 st050076 49.1 µM -0.698479237470702 0.258300847434993 no 2483 0.242438768965517 3690 3895976
SGTC_826 1683-5028 118 µM -0.698492556547124 0.258296029982694 no 2484 0.242434605626013 3704 722377
SGTC_3126 9127922 49.47 µM -0.699929711482595 0.25777649097545 no 2485 0.241985600629033 3699 45595682
SGTC_2529 gangaleoidin 93.61 µM -0.700245865978102 0.257662272303248 no 2486 0.241886886211245 3724 4565183
SGTC_2053 5265679 138 µM -0.700641170228731 0.257519495790684 no 2487 0.241763489232763 3658 764595
SGTC_738 1315-0003 72.4 µM -0.701520030108033 0.257202215321506 no 2488 0.24148926944712 3679 6251474
SGTC_194 1486-1323 56.904 µM -0.701530701548589 0.257198364034346 no 2489 0.241485940807782 3668 5178754
SGTC_2831 7999036 19.48 µM -0.70166748357931 0.25714900251266 no 2490 0.241443277917375 3678 2988270
SGTC_2931 9014674 55.67 µM -0.701980960585563 0.257035894379905 no 2491 0.2413455185663 3685 2996810
SGTC_2874 9043904 71.43 µM -0.703472881970955 0.256497937221934 no 2492 0.240880550399138 3661 4463428
SGTC_596 1155-0152 116 µM -0.704100014596633 0.256271980903041 no 2493 0.240685245520343 3673 280313
SGTC_703 3875-0075 71.8 µM -0.704222452828535 0.25622787843326 no 2494 0.240647125232932 3721 2850814
SGTC_340 k038-0059 454 µM -0.704854821277147 0.256000161199027 no 2495 0.240450294068991 3681 23733424
SGTC_3319 9138450 16.7555 µM -0.705471841440931 0.255778072726238 no 2496 0.24025832476185 3652 2029690
SGTC_2951 9072950 58.06 µM -0.705516046370149 0.255762165592357 no 2497 0.24024457478806 3703 16488155
SGTC_3130 9127414 49.47 µM -0.706164492418492 0.255528881795109 no 2498 0.240042924485687 3696 1494646
SGTC_1425 4048-4433 7.33 µM -0.707354680178084 0.255100991390044 no 2499 0.239673046480458 3742 23734946
SGTC_2924 9010168 62.78 µM -0.7099541325078 0.25416775391845 no 2500 0.238866290009251 3739 2993929
SGTC_865 0488-0499 301 µM -0.710900066673009 0.253828596013746 no 2501 0.238573082350701 3691 9634651
SGTC_2790 5423970 71.43 µM -0.711757087724414 0.253521522518886 no 2502 0.238307604938217 3718 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1121 fusaric acid 630.51 nM -0.712938809065386 0.253098428157884 no 2503 0.23794181140535 3704 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2241 6772625 37.8075 µM -0.713851089739349 0.252772056476808 no 2504 0.23765963202419 3644 2285411
SGTC_1963 st076565 50.3 µM -0.715091809484845 0.252328540409808 no 2505 0.237276157327238 3715 4914280
SGTC_2214 7179297 48.276 µM -0.718183564831357 0.251225128039924 no 2506 0.236322055152008 3722 769744
SGTC_126 0417-1624 672.48 µM -0.718314921884066 0.251178304772252 no 2507 0.236281565773228 3795 41912 YDL195W SEC31
SGTC_233 rapamycin 362 pM -0.718730267006891 0.251030282070478 no 2508 0.236153565307829 3707 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.71924311952609 0.250847572911075 no 2509 0.235995567865382 3665 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_94 0334-0113 514.748 µM -0.71927961032477 0.250834575359531 no 2510 0.235984328154195 3685 6795178
SGTC_4 0960-0234 25.671 µM -0.719404550012155 0.250790076155604 no 2511 0.23594584709804 3687 6821112
SGTC_931 2812-0076 566 µM -0.719704432615059 0.250683285382356 no 2512 0.235853498252429 3728 3450959
SGTC_993 3909-8757 62.7 µM -0.720048223505095 0.25056088812808 no 2513 0.235747652370154 3676 4288324 YLR208W SEC13
SGTC_469 w7 172 µM -0.723953713779386 0.249172671869649 no 2514 0.23454707595311 3756 45115570 A P450 inhibitor.
SGTC_207 4185-0010 4.486 µM -0.724220333774076 0.249078050516587 no 2515 0.23446523851151 3768 3761753
SGTC_1485 3909-9022 254 µM -0.724776340430997 0.248880789611067 no 2516 0.234294626369059 3745 714516
SGTC_1987 st072290 61.9 µM -0.725599273818593 0.248588980714109 no 2517 0.23404223320804 3720 54697379
SGTC_2968 9090663 33.37 µM -0.728325651035595 0.247623521858074 no 2518 0.233207131861967 3721 25236811
SGTC_1133 3473-0247 50 µM -0.728447954950849 0.247580258844855 no 2519 0.233169708436609 3739 711311
SGTC_2138 5575593 77.673 µM -0.731036772892212 0.246665454824047 no 2520 0.23237834602273 3713 762213
SGTC_2930 9013230 14.89 µM -0.733141339121453 0.245923105705117 no 2521 0.231736114512703 3717 2995857
SGTC_2038 4100038 30.985 µM -0.733309080442732 0.245863989503298 no 2522 0.231684968992827 3730 3596803
SGTC_1550 gossypolone 36.6 µM -0.734863363643947 0.245316584503971 no 2523 0.231211356299892 3734 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_413 propylparaben 100 µM -0.736271757094093 0.244821126935966 no 2524 0.230782665227891 3701 7175 A pharmaceutical preservative.
SGTC_2137 5261020 140 µM -0.736507590704499 0.244738215902443 no 2525 0.230710924895488 3710 763655
SGTC_1926 methyl fluorone black 53.6 µM -0.736646597591116 0.244689352916232 no 2526 0.230668644985395 3569 72721 Reacts with homocysteine.
SGTC_2882 9058044 58.44 µM -0.736692639552933 0.244673169640652 no 2527 0.230654641957319 3681 18076804
SGTC_42 0133-0086 60.653 µM -0.736826265630118 0.244626204714027 no 2528 0.230614004117349 3665 162923 Model of phenazepam hydroxylation.
SGTC_1325 1431-0015 227 µM -0.738013429725119 0.244209170997394 no 2529 0.230253144124141 3690 1103340
SGTC_315 k915-0449 187 µM -0.738264341849286 0.244121078261485 no 2530 0.230176915294479 3778 20970215 YNL149C PGA2
SGTC_2028 5153890 36.43 µM -0.738984842342013 0.24386821303365 no 2531 0.229958100778433 3713 2830968 YPR165W RHO1
SGTC_1241 0364-0022 50.8 µM -0.739415042138993 0.243717298503294 no 2532 0.229827505517291 3757 4563895
SGTC_1654 st012436 41.8 µM -0.74060907564748 0.24329869462772 no 2533 0.229465251788746 3696 4323132
SGTC_2351 9026858 72.31 µM -0.741803155800157 0.242880463326389 no 2534 0.229103304131447 3680 1409300
SGTC_227 fluconazole 33.516 µM -0.742255371295443 0.242722174677237 no 2535 0.228966312947269 3734 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_122 0236-0016 402.397 µM -0.74235012518112 0.242689015123645 no 2536 0.228937614654532 3791 6808838
SGTC_3116 9124943 49.47 µM -0.742616729190407 0.242595728996257 no 2537 0.228856878612597 3685 41905195 YPL160W CDC60
SGTC_124 0136-0217 7.121 µM -0.74293705432404 0.242483671253659 no 2538 0.228759895270578 3820 3976905
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.743261088756755 0.242370344437581 no 2539 0.228661812361331 3751 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_6 0844-0013 19.835 µM -0.744190330921113 0.242045513324203 no 2540 0.228380668398355 3838 1584900
SGTC_2254 7938975 95.19 µM -0.744300595218053 0.242006984392488 no 2541 0.228347320625295 3782 2969277
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.744982088752729 0.24176892839414 no 2542 0.22814127392197 3768 688751
SGTC_874 0599-0792 117 µM -0.74535963149698 0.241637101728093 no 2543 0.228027170476785 3751 765305
SGTC_1932 st074806 40.9 µM -0.746501920273161 0.241238486313558 no 2544 0.227682136012495 3830 17251235
SGTC_1784 st039334 36.3 µM -0.747773811042112 0.240795065555892 no 2545 0.227298300614893 3792 3496984
SGTC_3211 9128781 49.47 µM -0.747839520429104 0.240772169269931 no 2546 0.227278480529171 3800 17194361
SGTC_583 1488-1091 88.9 µM -0.748614017465952 0.240502386840231 no 2547 0.227044940465596 3843 4303273
SGTC_2587 piperic acid 92.2 µM -0.749975553016104 0.240028519177685 no 2548 0.226634714346313 3765 5370536
SGTC_2334 9017922 200 µM -0.75011174790624 0.239981146049543 no 2549 0.226593702309546 3803 3163164
SGTC_1094 duloxetine 25.4 µM -0.750383107373731 0.239886773371536 no 2550 0.226512000981708 3754 60834 A selective serotonin reuptake inhibitor.
SGTC_1613 st002381 52.1 µM -0.750526426322982 0.239836938456383 no 2551 0.226468857003678 3720 551167
SGTC_2801 7907800 81.82 µM -0.75066715281174 0.239788010488354 no 2552 0.226426497961599 3817 6620925
SGTC_2258 7960471 200 µM -0.751328434397466 0.239558168185977 no 2553 0.22622751039078 3745 2974708
SGTC_7 0192-1582 4.227 µM -0.75177875162207 0.239401719841285 no 2554 0.226092061099049 3795 252616
SGTC_1811 st050069 61.5 µM -0.753430946713235 0.238828195629527 no 2555 0.225595496080335 3723 3877702
SGTC_1233 0325-0408 14.2 µM -0.753512487050755 0.238799910117599 no 2556 0.225571005232517 3808 12874
SGTC_2601 securinine 100 µM -0.754140693591277 0.238582053127473 no 2557 0.22538237225784 3732 442872 A GABA receptor antagonist.
SGTC_649 1123-0311 367 µM -0.755020729674224 0.238277046694244 no 2558 0.225118272120933 3734 693629 YIL048W NEO1
SGTC_1213 1315-0166 115 µM -0.756216644697124 0.237862904245785 no 2559 0.224759657432109 3819 768401
SGTC_62 0180-0423 3.232 µM -0.75719519302738 0.237524329193008 no 2560 0.224466464840091 3725 30102 YGL099W LSG1
SGTC_2499 avocadenofuran 51.48 µM -0.757976680183254 0.237254126855463 no 2561 0.224232471665904 3763 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3184 9108758 49.47 µM -0.759937889064372 0.23657677505438 no 2562 0.223645856120483 3769 902885
SGTC_275 trichlorophene 5.69 µM -0.761544676422657 0.236022625385722 no 2563 0.223165902340933 3824 62616
SGTC_2409 alverine citrate 63.97 µM -0.761740745512814 0.235955053973107 no 2564 0.223107375892943 3946 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_145 3737-0113 38.366 µM -0.76325995211541 0.235431850367362 no 2565 0.222654190389671 3781 6849351
SGTC_2405 ticlatone 3.52 µM -0.76481361590009 0.234897442827319 no 2566 0.222191269361507 3683 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1317 1273-0028 910 nM -0.766348965516384 0.234369993983703 no 2567 0.221734345182461 3762 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_551 k048-0028 34.9 µM -0.767719399402716 0.23389975387158 no 2568 0.221326954191486 3748 6836383
SGTC_1615 st002656 86.5 µM -0.770454958831895 0.232962660260985 no 2569 0.220515031576962 3783 1584458
SGTC_2432 5630864 12.22 µM -0.771125254243559 0.232733362255306 no 2570 0.220316346450369 3789 5714970
SGTC_929 2805-0021 398 µM -0.772200059740664 0.232365949361539 no 2571 0.219997973081339 3863 3098024
SGTC_2586 curcumin 80 µM -0.773698926696538 0.231854113903847 no 2572 0.219554427439851 3808 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1530 rhein 70.4 µM -0.775869978484636 0.231113854533488 no 2573 0.218912880124701 3843 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_349 k015-0014 24 µM -0.776607216502923 0.230862780211976 no 2574 0.218695271299023 3794 2196908
SGTC_1527 coumarin 137 µM -0.776911950218392 0.230759044381134 no 2575 0.218605360139058 3896 323 A hepatotoxic, DNA x-linker.
SGTC_1459 k035-0031 35.7 µM -0.777531150726425 0.230548339659369 no 2576 0.218422731657483 3659 3877128 YMR208W ERG12
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.778417289855494 0.23024698682468 no 2577 0.218161524583677 3826 4174840
SGTC_3031 9088762 49.47 µM -0.779070181832003 0.230025096299982 no 2578 0.217969186967413 3771 205253
SGTC_1672 st016598 6.51 µM -0.779397680835681 0.229913838245326 no 2579 0.217872744781603 3836 4665860 YNL267W PIK1
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.779470460453089 0.229889117624517 no 2580 0.21785131592042 3802 2724 A muscle relaxant with antifungal properties.
SGTC_2465 5809242 33.21 µM -0.780271932908283 0.22961698466774 no 2581 0.217615414851065 3796 2731748
SGTC_2607 solasodine 47.35 µM -0.780512538876968 0.229535324250033 no 2582 0.21754462497085 3831 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_847 0342-0274 5.54 µM -0.781341412152969 0.229254133579524 no 2583 0.217300859820106 3810 18097
SGTC_3208 9114115 49.47 µM -0.781985427435854 0.22903578836168 no 2584 0.217111568904784 3834 650895
SGTC_1196 1588-0294 184 µM -0.782129966345899 0.228986800311545 no 2585 0.217069098686213 3827 6144269
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.783036339538117 0.228679740581406 no 2586 0.21680288631159 3791 688803
SGTC_2922 7999257 32.47 µM -0.783044801838154 0.228676874826106 no 2587 0.216800401725188 3777 2988377
SGTC_339 3091-4833 71.4 µM -0.783136768386606 0.228645731683313 no 2588 0.216773400809361 3737 3240077
SGTC_3275 9138069 49.47 µM -0.783859497894566 0.228401072701173 no 2589 0.216561278757849 3913 17617007
SGTC_50 0929-0078 56.389 µM -0.784977381200718 0.228022935834238 no 2590 0.21623341518889 3702 1377751
SGTC_3350 9150499 3.57 µM -0.784996563822159 0.228016450166659 no 2591 0.216227791634436 3784 4910996 YPR165W RHO1
SGTC_1218 1348-1416 30.7 µM -0.785071686931632 0.227991051951066 no 2592 0.216205769448317 3766 6787668
SGTC_1182 1222-0449 220 µM -0.785203942874152 0.227946341682105 no 2593 0.216167002044876 3804 658318
SGTC_154 3389-1638 511.116 µM -0.785224615051921 0.227939353718802 no 2594 0.216160942895265 3764 5238686
SGTC_1480 1070-0044 41.2 µM -0.786948255650156 0.22735712334157 no 2595 0.21565607871791 3813 3124987
SGTC_2517 totarol 10 µM -0.787571520097043 0.227146796632808 no 2596 0.215473689439153 3819 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_162 k030-0015 37.8 µM -0.78786119036528 0.227049081901185 no 2597 0.215388952111629 3880 1809920 YMR134W ERG29
SGTC_3017 9080681 49.47 µM -0.789102379554149 0.226630658892143 no 2598 0.215026085646395 3840 16451914
SGTC_2136 5328288 199.296 µM -0.78932254636768 0.226556482917527 no 2599 0.214961756114257 3833 262395
SGTC_1367 1812-0510 76.9 µM -0.789936028338893 0.226349868212716 no 2600 0.214782564602479 3852 1142582 YDR527W RBA50
SGTC_3283 9109332 35.8195 µM -0.790047191955705 0.226312440790922 no 2601 0.214750104191085 3680 17027281
SGTC_3072 9116419 49.47 µM -0.790629012523054 0.226116606006327 no 2602 0.214580255769724 3836 17170162
SGTC_2146 5545642 200 µM -0.791552243122553 0.225806052781973 no 2603 0.214310901283957 3805 825326
SGTC_2823 7987624 58.44 µM -0.791933950427928 0.225677725875094 no 2604 0.214199594857396 3798 2239440
SGTC_114 0364-0001 490.298 µM -0.794353509817435 0.224865249954467 no 2605 0.21349483041683 3889 4003655
SGTC_1377 2944-0135 198 µM -0.796088459996951 0.224283684658745 no 2606 0.212990310564128 3881 1894137
SGTC_2083 5306046 65.942 µM -0.796091136274348 0.224282788215277 no 2607 0.212989532846074 3857 539837
SGTC_1240 0356-0016 42.1 µM -0.797944478544335 0.223662483020866 no 2608 0.212451355232503 3832 4305613
SGTC_2055 5235184 200 µM -0.798996014806612 0.223310972833061 no 2609 0.212146361397449 3869 2836034
SGTC_2119 5528445 120.635 µM -0.800909655677179 0.222672083528777 no 2610 0.211591974915692 3842 791935
SGTC_3079 9117512 49.47 µM -0.801861978182307 0.222354529219674 no 2611 0.211316401084416 3844 7185044
SGTC_975 1335-0046 28.5 µM -0.803012146918369 0.22197134723416 no 2612 0.210983856890567 3838 16486740
SGTC_3239 9133757 49.47 µM -0.806318765014723 0.22087184058683 no 2613 0.210029536665239 3843 17036923
SGTC_3092 9117248 49.47 µM -0.807322964997947 0.22053854534641 no 2614 0.209740218220927 3906 17141857
SGTC_2661 dactinomycin 12.96 µM -0.808011382252829 0.220310225385961 no 2615 0.209542014884087 3831 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3093 9117344 49.47 µM -0.808272979880025 0.220223499654506 no 2616 0.209466726781467 3896 24824913
SGTC_463 ikarugamyin 104 µM -0.811397851371243 0.219189046424548 no 2617 0.208568616323568 3885 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.811871463999586 0.21903250647596 no 2618 0.208432695056074 3825 4620898
SGTC_2881 9058953 51.95 µM -0.811909826106325 0.219019829726143 no 2619 0.208421687869045 3826 17122249
SGTC_332 4112-0506 40.9 µM -0.812238636597946 0.21891119168003 no 2620 0.208327356785613 3821 2790355
SGTC_903 1134-0042 114 µM -0.812266053696466 0.218902134549458 no 2621 0.208319492345215 3845 701009
SGTC_2446 5162541 200 µM -0.812453898644594 0.218840086508654 no 2622 0.208265614789811 3810 1549321
SGTC_1851 st056236 18.9 µM -0.813107503474604 0.218624269779218 no 2623 0.20807821239289 3816 5393171
SGTC_1839 st053978 48 µM -0.813538495864706 0.218482025515005 no 2624 0.207954692187776 3862 3788398
SGTC_3036 9090181 49.47 µM -0.814431496038636 0.218187470374334 no 2625 0.207698900742795 3867 25236586
SGTC_1053 3366-3204 134 µM -0.814593032656215 0.21813421214908 no 2626 0.207652649968597 3875 3632071 YPR165W RHO1
SGTC_3010 9080089 71.4286 µM -0.814594840864897 0.218133616029535 no 2627 0.207652132281095 3857 17027233
SGTC_1912 st060209 90.8 µM -0.817159501931662 0.21728905927283 no 2628 0.20691864136959 3886 688787
SGTC_585 0kpi-0023 191 µM -0.817902926992057 0.217044598885388 no 2629 0.206706309434095 3786 64601
SGTC_1539 benzyladenosine 56 µM -0.818023671625298 0.217004909447932 no 2630 0.206671835368019 3833 92208 A nucleotide analog.
SGTC_2228 7354201 200 µM -0.818103631062599 0.216978628641555 no 2631 0.206649007847001 3869 753451
SGTC_923 1900-2434 73.3 µM -0.818526710968221 0.216839602741936 no 2632 0.206528248141254 3828 5910570
SGTC_2981 9013952 38.96 µM -0.819392185172457 0.216555364640075 no 2633 0.206281346081832 3825 2996344
SGTC_1160 4092-0570 10.5 µM -0.81949496707095 0.216521623445739 no 2634 0.20625203613818 3845 4994975
SGTC_2067 5224629 34.075 µM -0.82039610354725 0.216225929047583 no 2635 0.20599516800996 3848 2835000
SGTC_1733 st037357 54.9 µM -0.820435875239334 0.216212883953882 no 2636 0.205983835498965 3790 1272339 YGL099W LSG1
SGTC_263 alizarin 107.927 µM -0.820652256143393 0.216141919117725 no 2637 0.205922186592994 3869 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1732 st034308 51.822 µM -0.82137601188263 0.215904652366356 no 2638 0.205716061483048 3744 830119
SGTC_1483 3453-0561 55.9 µM -0.822009610884631 0.215697065385049 no 2639 0.205535713506339 3879 4546991
SGTC_100 0086-0128 49.5915 µM -0.822991601956163 0.215375562938498 no 2640 0.205256384576832 3924 93297
SGTC_346 4513-0042 7.16 µM -0.824077725183572 0.215020291800861 no 2641 0.204947697908819 3849 2827372
SGTC_2033 5192550 145 µM -0.824849544642521 0.214768036455926 no 2642 0.204728507241645 3862 182073
SGTC_76 0433-0009 400.328 µM -0.825101275273691 0.214685800015731 no 2643 0.204657047885374 3977 2841569
SGTC_2756 carbadox 75.1 µM -0.825685482371863 0.214495019269978 no 2644 0.204491264855001 3878 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3195 9113082 49.47 µM -0.827386962515098 0.21393993978423 no 2645 0.2040088838885 3783 17018038
SGTC_3003 9075612 71.4286 µM -0.828305124035006 0.213640752641925 no 2646 0.203748860848411 3899 6501993
SGTC_1702 st027038 51 µM -0.829101056590981 0.21338159171999 no 2647 0.203523612963573 3903 5521182
SGTC_97 0535-0701 19.132 µM -0.829175593999157 0.213357331233702 no 2648 0.203502526582021 3790 2832013 YGL099W LSG1
SGTC_1807 st050092 58.9 µM -0.829711990868226 0.213182791845909 no 2649 0.203350820151511 3901 5008496
SGTC_556 4058-0063 51.5 µM -0.830962979347369 0.212776053610337 no 2650 0.202997271685909 3931 6615692
SGTC_2133 5320837 200 µM -0.832145115810849 0.212392118112131 no 2651 0.202663519411484 3887 2841355
SGTC_3321 9137793 26.8275 µM -0.834392049820597 0.211663473544613 no 2652 0.202030047892513 3849 4904192
SGTC_2725 haloperidol 53.21 µM -0.834908003144745 0.211496364972863 no 2653 0.201884754160065 3831 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3030 9087619 49.47 µM -0.835848679952101 0.21119189452988 no 2654 0.20162001829511 3918 25236973
SGTC_586 0957-0265 8.15 µM -0.836237117480523 0.211066243266021 no 2655 0.201510760524803 3744 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_424 splitomicin 100 mM -0.836937070597066 0.21083993400099 no 2656 0.201313970787749 3987 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2411 st077133 39.94 µM -0.837335595705108 0.210711146223441 no 2657 0.201201978126196 4005 1403142 YNL221C POP1
SGTC_1882 5615643 20 µM -0.838786397138275 0.210242693725605 no 2658 0.200794592704625 3798 2253075
SGTC_2593 nobiletin 86.24 µM -0.840040307084632 0.209838309140869 no 2659 0.200442893610036 3900 72344 An anti-infammatory.
SGTC_1260 0700-1617 7.75 µM -0.840455809123892 0.209704411108255 no 2660 0.200326434457751 3915 2853078
SGTC_343 4130-2827 29.8 µM -0.842496436382156 0.209047536344487 no 2661 0.199755066790714 3945 1118244
SGTC_2343 7990716 14.84 µM -0.842828163804493 0.208940868417818 no 2662 0.199662277131369 3886 6456862
SGTC_2482 5981709 142.65 µM -0.84296256801546 0.208897659477401 no 2663 0.199624689429204 3884 877755
SGTC_2360 9040895 200 µM -0.843754674136598 0.208643116176781 no 2664 0.199403254239023 3938 4914414
SGTC_1052 3253-3998 198 µM -0.845433620440759 0.208104191637444 no 2665 0.198934389899418 3846 5450317
SGTC_3344 9148862 3.898 µM -0.846083051322801 0.207895951547956 no 2666 0.198753207493067 3930 4905352
SGTC_1123 mangostin 811.285 nM -0.846275283323896 0.207834335942925 no 2667 0.19869959646168 3921 5281650 An antioxidant.
SGTC_1293 1000-1278 195 µM -0.849069165851786 0.206940038375552 no 2668 0.197921403302768 3949 678847
SGTC_1073 triclabendazole 3.09 µM -0.852033307255115 0.205993736570163 no 2669 0.197097802990131 3985 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2385 9074692 200 µM -0.853145864575896 0.205639216256774 no 2670 0.196789209918497 3932 17046906
SGTC_89 0302-0250 142.109 µM -0.854099009787475 0.205335781412067 no 2671 0.196525066267148 3988 4203518 YLR208W SEC13
SGTC_181 1447-1644 8.07 µM -0.8555680503839 0.204868631878297 no 2672 0.196118374295816 3917 534600
SGTC_589 1227-0070 34.1 µM -0.856279371653476 0.204642661587879 no 2673 0.195921634318397 3948 2841384
SGTC_581 0958-0271 211 µM -0.856540206839584 0.204559837462192 no 2674 0.19584952153428 3920 4591145
SGTC_3220 9131269 49.47 µM -0.857925380946886 0.204120331470187 no 2675 0.195466834108958 3940 17722206
SGTC_2789 5281112 71.43 µM -0.858540400961464 0.203925370397216 no 2676 0.195297065832697 3952 765948
SGTC_3164 9100705 49.47 µM -0.858944462225079 0.203797343577055 no 2677 0.195185578754656 3946 17174235
SGTC_1828 st055811 49 µM -0.860308364215824 0.203365545151248 no 2678 0.194809541717001 3949 5877589
SGTC_1450 4112-4260 37.6 µM -0.862120523343041 0.202792678026987 no 2679 0.194310599359194 3865 1633175
SGTC_482 fipronil 114 µM -0.86250812528999 0.202670273000493 no 2680 0.19420398189033 3971 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2191 5911152 200 µM -0.866877021181466 0.201293628058352 no 2681 0.193004697588409 3931 2875902
SGTC_917 harmaline 728.087 nM -0.867445582303945 0.201114886835394 no 2682 0.192848957903868 3923 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1649 st011737 51.3 µM -0.868134664832494 0.200898384371884 no 2683 0.192660308052855 3915 1761035
SGTC_1905 st060207 84.5 µM -0.868936802619231 0.2006465373611 no 2684 0.192440849213073 3862 1948547
SGTC_411 enrofloxacin 100 µM -0.869148735301731 0.200580028576009 no 2685 0.192382891567905 4030 71188 A bacterial gyrase inhibitor.
SGTC_1308 1187-1617 41.4 µM -0.869966080171459 0.20032365313326 no 2686 0.192159470644697 3926 2882570
SGTC_1363 1636-0063 10.4 µM -0.871062358178029 0.199980094409635 no 2687 0.19186005280868 3924 6072185
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.871935480549873 0.199706723254396 no 2688 0.191621788166971 3969 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1222 0366-0074 1.18 µM -0.87453729845129 0.198893438603618 no 2689 0.190912858602726 3984 286520
SGTC_345 1362-0200 395 µM -0.874999239139303 0.198749252649963 no 2690 0.190787159848535 3944 1419823
SGTC_1667 st014849 34.6 µM -0.876855642737714 0.198170447590575 no 2691 0.190282525886794 3976 5348460
SGTC_2051 5263410 176 µM -0.876913786440384 0.1981523355109 no 2692 0.190266733694742 3970 227584
SGTC_2687 chenodiol 100 µM -0.878987063235615 0.197507151880899 no 2693 0.18970414512499 4014 5702181 A cholesterol synthesis inhibitor.
SGTC_1564 D-Arginine 115 µM -0.87899500529217 0.197504682834469 no 2694 0.189701991998212 3951 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3154 9100113 49.47 µM -0.882220315654798 0.196503533522429 no 2695 0.18882883890523 3982 25237525
SGTC_664 1222-0054 14.9 µM -0.88261411374291 0.196381508014684 no 2696 0.18872240015482 3911 6813991
SGTC_599 1935-0052 86.5 µM -0.884206071131545 0.19588867934735 no 2697 0.188292490815352 3954 9557311
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.884418778838494 0.195822887446619 no 2698 0.188235094724962 3926 66535 A nucleotide analog.
SGTC_1518 st038567 90.8 µM -0.884700680855432 0.195735713954243 no 2699 0.188159044189383 3911 77966
SGTC_2715 st079500 56.4 µM -0.884923422528503 0.195666851472274 no 2700 0.18809896713571 3892 28246688
SGTC_960 1222-0186 7.7 µM -0.88548226322468 0.195494145871396 no 2701 0.187948290827751 4008 3126296
SGTC_2306 7482397 179.52 µM -0.885540225857995 0.1954762382471 no 2702 0.187932667034911 3959 891448
SGTC_2537 larixol 68.93 µM -0.887197771551499 0.194964559237084 no 2703 0.187486215999697 3962 6708759
SGTC_220 paclitaxel 373.376 µM -0.888380343266854 0.194600001414976 no 2704 0.187168097639634 3907 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_659 k018-0002 107 µM -0.888611849493104 0.194528682311671 no 2705 0.18710586027244 3955 6797879 YHR007C ERG11
SGTC_3167 9103034 49.47 µM -0.889052480148894 0.194392983126729 no 2706 0.186987437958645 3991 5127859
SGTC_2147 5545932 89.7195 µM -0.88972078926677 0.194187276776937 no 2707 0.18680791412309 3981 797404
SGTC_3143 9086658 49.47 µM -0.891451393243411 0.193655211303004 no 2708 0.186343528452303 4038 25236626
SGTC_1772 st048439 82.2 µM -0.891666366414588 0.193589181012299 no 2709 0.186285893102955 4006 2927068 YDL195W SEC31
SGTC_681 1642-0006 26.6 µM -0.892423185036938 0.193356828943363 no 2710 0.186083074267357 3969 4446530
SGTC_2272 7805186 180 µM -0.892569603291134 0.193311896499215 no 2711 0.186043851638748 3970 2956062 YPR165W RHO1
SGTC_663 1486-0733 13.9 µM -0.89323193147601 0.19310872260325 no 2712 0.185866490718561 3960 722445 YPR165W RHO1
SGTC_3333 9141820 12.094 µM -0.893587262812311 0.192999775933143 no 2713 0.185771381889265 3953 1939433
SGTC_818 4072-2707 53.5 µM -0.893854625765505 0.192917825636091 no 2714 0.185699838792963 3881 882871
SGTC_390 dec-rvkr-cmk 16.7 µM -0.894944538776543 0.192583972787299 no 2715 0.185408368142512 3995 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2289 7946404 165.07 µM -0.895968790126478 0.192270554931757 no 2716 0.185134716102173 3999 1246120 YPR165W RHO1
SGTC_889 0919-1524 82.7 µM -0.898086949732055 0.191623394846999 no 2717 0.184569597959917 3987 3905452
SGTC_3273 9137859 49.47 µM -0.898367777055594 0.191537694118824 no 2718 0.184494754761183 4036 2377234
SGTC_510 ag-490 170 µM -0.898585022813642 0.191471412835872 no 2719 0.184436869616446 4085 5328779
SGTC_1596 piperlongumine 63 µM -0.899426942035983 0.191214677613486 no 2720 0.184212646938264 4007 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1604 st002052 72.4 µM -0.899887373722047 0.191074362678866 no 2721 0.184090095056904 4034 6254834 YHR062C RPP1
SGTC_1234 0326-0494 15.5 µM -0.901223132757389 0.190667652252141 no 2722 0.183734846911745 4051 1547813
SGTC_2534 helenine 20.12 µM -0.903431772607444 0.189996334738904 no 2723 0.183148391778696 3964 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2185 6113692 200 µM -0.903820929446984 0.189878200991316 no 2724 0.183045180965836 3984 874150
SGTC_1960 st011366 51.8 µM -0.903915212563949 0.189849586891501 no 2725 0.183020180989955 3981 3972846
SGTC_2110 5483698 200 µM -0.904124133888348 0.189786190547843 no 2726 0.182964791302773 3963 2848765 YHR062C RPP1
SGTC_1267 0828-0272 9.49 µM -0.904256352927522 0.18974607593449 no 2727 0.182929742501811 4063 745334
SGTC_500 h-89 112 µM -0.904598481508467 0.189642299993836 no 2728 0.182839070046269 4018 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1941 st076221 61.8 µM -0.905251897552198 0.189444200014623 no 2729 0.182665976752871 3904 2828568
SGTC_2338 7999974 200 µM -0.905328806679406 0.189420891402689 no 2730 0.182645609859375 3993 315925
SGTC_3113 9123498 49.47 µM -0.905551767465711 0.189353329340627 no 2731 0.182586573924775 4034 8897275
SGTC_3099 9120367 49.47 µM -0.909356408480521 0.188202725975794 no 2732 0.181581011973589 3999 24824940
SGTC_1470 k295-0292 231 µM -0.91030146095269 0.187917592560016 no 2733 0.181331774147066 4055 5045612
SGTC_248 streptozotocin 5.23457 mM -0.910302697625914 0.18791721961603 no 2734 0.181331448140769 3986 5300 DNA alkylating agent.
SGTC_1381 2324-0066 62.1 µM -0.9141336858154 0.186764101406254 no 2735 0.180323302007798 4053 10885928
SGTC_188 3229-0966 278.469 µM -0.916780117479158 0.185970095389176 no 2736 0.179628936687763 4020 5722370
SGTC_2702 st077768 96.8 µM -0.916928778941349 0.185925554827908 no 2737 0.179589981105447 3984 6484119
SGTC_2871 9038510 12.99 µM -0.917068547975431 0.18588368456679 no 2738 0.179553360557728 3927 4945164
SGTC_1391 3442-0225 151 µM -0.917675129982233 0.185702040071327 no 2739 0.179394485856123 3953 5227075
SGTC_2762 leflunomide 42.06 µM -0.917873101781431 0.185642780112324 no 2740 0.179342652628947 3960 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3255 9139072 49.47 µM -0.919605560678155 0.185124694650577 no 2741 0.178889459905143 3995 17646060
SGTC_1063 disulfiram 1.84 µM -0.921413731113559 0.184584926775797 no 2742 0.178417231278977 3978 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3102 9121669 49.47 µM -0.923499828115999 0.183963410632884 no 2743 0.177873394958142 4013 41905072
SGTC_2623 humulene 100 µM -0.926159300834197 0.183172959280496 no 2744 0.177181599923952 4012 6187145 An anti-inflammatory.
SGTC_3326 9140064 16.379 µM -0.926289424685885 0.183134338168388 no 2745 0.177147795138164 3938 1868434
SGTC_1774 st048371 48.465 µM -0.926354642744065 0.183114983182893 no 2746 0.177130853716516 3973 4242727
SGTC_2584 androsterone 48.74 µM -0.926452410099883 0.18308597082172 no 2747 0.177105459017399 3969 2754130 A steroid.
SGTC_3122 9126309 49.47 µM -0.928037430354851 0.182616017877129 no 2748 0.1766940769667 4038 17591206
SGTC_971 1315-0384 26.7 µM -0.928195395712681 0.182569223016407 no 2749 0.176653111182634 4025 6769120
SGTC_2867 9039098 71.43 µM -0.929053680494884 0.182315099966604 no 2750 0.17643063375345 3969 6463460
SGTC_2723 salbutamol 83.58 µM -0.931419546556431 0.181615753655487 no 2751 0.17581829185134 4022 9884233 β2-adrenoceptor agonist
SGTC_1788 fluconazole 20 µM -0.933425453131722 0.181024127731042 no 2752 0.175300171796972 4066 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_34 0469-0683 81.75 µM -0.934226444858754 0.180788219456249 no 2753 0.175093548641208 3977 3690923
SGTC_1669 st015249 58.4 µM -0.934757459423542 0.180631931202882 no 2754 0.174956653764109 4089 722793
SGTC_2287 7945887 168.79 µM -0.935085288962199 0.180535486696228 no 2755 0.174872173643101 4029 1245853
SGTC_2816 7982706 58.44 µM -0.938206428905071 0.179618893503565 no 2756 0.174069167579707 4074 2981853
SGTC_1668 st014914 51.6 µM -0.938478040430565 0.179539267204185 no 2757 0.173999398479447 4013 2839556
SGTC_2698 st077697 67.5 µM -0.940905076787249 0.178828736456576 no 2758 0.173376752870382 3991 3154499
SGTC_1443 4112-3303 14 µM -0.941032098422962 0.178791598849141 no 2759 0.173344205129647 4050 704433
SGTC_833 3852-0053 558 µM -0.941602570454692 0.178624868503014 no 2760 0.173198076618606 4088 3123681
SGTC_1342 1486-1464 234 µM -0.94251252410377 0.178359121487704 no 2761 0.172965151059232 4057 3253938
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.944326313885771 0.177830157637084 no 2762 0.172501461586132 4060 23665772 A membrane-active detergent.
SGTC_19 0279-0214 38.434 µM -0.944423772924585 0.177801763250766 no 2763 0.172476568962238 4087 3566274 YBR002C RER2
SGTC_2877 9040724 71.43 µM -0.945475166917481 0.177495624767902 no 2764 0.172208171517032 4015 6463895
SGTC_1265 0819-1001 68.8 µM -0.947088921894884 0.177026389128834 no 2765 0.171796734632967 3988 3106768
SGTC_2925 9010536 32.5 µM -0.94899727132972 0.17647250596654 no 2766 0.171310999941696 3989 2994177
SGTC_165 k038-0023 64.381 µM -0.950423467171826 0.176059280588264 no 2767 0.1709485622792 4040 46368543
SGTC_2072 5231554 129 µM -0.951729442846187 0.175681425511644 no 2768 0.17061710665667 4071 789545
SGTC_2383 9036125 200 µM -0.952107107309087 0.175572252527176 no 2769 0.170521332450492 3947 79580
SGTC_236 1509-0011 5.31 µM -0.952279125840543 0.175522540693179 no 2770 0.170477720648 4086 3107280
SGTC_40 0327-0103 19.753 µM -0.95325376012119 0.175241048495303 no 2771 0.170230756835062 3911 409036
SGTC_2144 5628481 200 µM -0.959494278292681 0.173445463597595 no 2772 0.168654900364625 4027 2818399
SGTC_647 0140-0236 81 µM -0.95984824285046 0.173343969515115 no 2773 0.168565799076535 4041 990837
SGTC_603 3794-0023 45.9 µM -0.960339340209834 0.173203217272434 no 2774 0.168442228332555 4080 3802260
SGTC_3085 9117376 49.47 µM -0.961744017818648 0.172801027920128 no 2775 0.168089102661712 4131 16480349
SGTC_2895 9054447 58.44 µM -0.962377133412121 0.172619948093707 no 2776 0.16793009789079 4098 2697450
SGTC_195 4234-0266 16.654 µM -0.967952006878046 0.171030683211433 no 2777 0.16653416954498 4052 2303354
SGTC_2330 7979373 200 µM -0.969672130421882 0.170542212049731 no 2778 0.166104973222638 3997 1863007
SGTC_2800 7887935 81.82 µM -0.970080141051803 0.17042647864929 no 2779 0.166003273473655 4076 2961002
SGTC_3337 9144342 33.5465 µM -0.970376870678237 0.170342342029021 no 2780 0.165929336637351 4052 17682949
SGTC_2076 5212012 200 µM -0.972637657251885 0.169702177938267 no 2781 0.16536670994137 3996 604802
SGTC_2302 7771753 200 µM -0.973972056165767 0.169325054805491 no 2782 0.165035207057679 4064 2203047
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.974755345887512 0.169103934974211 no 2783 0.164840816018323 4093 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1554 st069299 38.7 µM -0.975260174417166 0.168961522033833 no 2784 0.164715610037651 4040 24207999
SGTC_375 3970-0961 9.27 µM -0.976091879688363 0.168727064707256 no 2785 0.164509467523216 4016 2898222
SGTC_144 4161-2749 112.381 µM -0.976113621920008 0.168720938388003 no 2786 0.164504080840711 3989 797501 YMR168C CEP3
SGTC_1158 4092-0494 91.8 µM -0.978364980707137 0.168087345776902 no 2787 0.163946920897671 4159 1148199
SGTC_1264 0783-0040 158 µM -0.978637489987922 0.168010758383401 no 2788 0.163879564236328 3952 2855798
SGTC_945 3381-0768 11.3 µM -0.979296723314875 0.167825576996025 no 2789 0.163716694502541 4112 1126236 YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM -0.979685309975873 0.167716482967516 no 2790 0.163620739788516 4045 3334711
SGTC_1108 betulinic acid 729.144 nM -0.981406373655747 0.16723385096173 no 2791 0.163196192165633 4064 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.982684636703624 0.166875971992221 no 2792 0.162881337164568 3986 5355888
SGTC_1754 st042065 16.137 µM -0.983072243321738 0.166767550342027 no 2793 0.162785942046188 3892 1126236 YIL048W NEO1
SGTC_45 0kpi-0036 14.9 µM -0.983768948975298 0.166572781544229 no 2794 0.162614564936453 4090 2795021
SGTC_2304 7443016 91.4 µM -0.984215920166632 0.166447905055207 no 2795 0.162504679860619 3984 939854
SGTC_2034 5197015 53.07 µM -0.984619654598736 0.166335160181856 no 2796 0.162405465815109 4084 780676
SGTC_1288 0973-0013 65.5 µM -0.986337833010346 0.16585590187815 no 2797 0.161983680171441 4112 4315430
SGTC_901 1112-0062 60.1 µM -0.986944203863664 0.165686977755081 no 2798 0.161834996210644 4076 1908457
SGTC_1942 st076330 65.2 µM -0.987901721463176 0.165420457019172 no 2799 0.161600391148484 4138 24208414
SGTC_2064 5220758 200 µM -0.989811283954682 0.164889767456656 no 2800 0.161133184199672 4146 788518
SGTC_1032 k061-1018 98.7 µM -0.99219610423849 0.164228548398667 no 2801 0.160550936272064 4191 4005393
SGTC_1952 st077036 64.1 µM -0.99290419615393 0.164032553235248 no 2802 0.160378322343227 4101 2937007
SGTC_1231 0242-0792 125 µM -0.99333402419966 0.163913653716721 no 2803 0.160273600898432 4072 3707635
SGTC_2187 6125751 200 µM -0.993734022219005 0.163803056064371 no 2804 0.160176187268892 4099 874498
SGTC_2572 astragaloside iv 100 µM -0.994309035009676 0.163644152492999 no 2805 0.160036219195115 4142 45006101 An anti-inflammatory agent.
SGTC_1149 3909-7961 23.3 µM -0.99731258330089 0.162815755590604 no 2806 0.159306403877687 4117 735261
SGTC_1389 3405-0187 19 µM -0.997763441160184 0.162691642062907 no 2807 0.15919704088628 4052 799890
SGTC_257 daunorubicin 18.5 µM -0.998983206156542 0.162356169990611 no 2808 0.158901413357526 4103 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3123 9126162 49.47 µM -1.00023363139332 0.162012733150671 no 2809 0.158598728577765 4150 25239884
SGTC_1126 isoteolin 1.0172 µM -1.00058614020003 0.161916000044192 no 2810 0.158513466728354 4039 133323
SGTC_2135 5326629 150.42 µM -1.00231981530911 0.161440804234358 no 2811 0.158094577627716 4049 5020077
SGTC_1070 indatraline 8.81 µM -1.00643302755562 0.160317025655067 no 2812 0.157103656397785 4115 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1401 3807-4679 7.6 µM -1.00839963814859 0.159781535065171 no 2813 0.156631323294434 4038 3291456
SGTC_1629 st005085 44.9 µM -1.00976446783868 0.159410592718912 no 2814 0.156304073720102 4055 24207091
SGTC_2259 7964009 200 µM -1.0116183348002 0.158907640383761 no 2815 0.155860287969832 4150 313134
SGTC_3140 9094243 49.47 µM -1.011908042015 0.158829137151234 no 2816 0.155791011874566 4089 19291112
SGTC_508 roscovitine 141 µM -1.01286859207706 0.158569034589048 no 2817 0.155561466087575 4171 160355 A CDKinase inhibitor.
SGTC_3134 9127454 49.47 µM -1.01322523360519 0.158472532558634 no 2818 0.155476295121877 4138 24262820
SGTC_1947 st076332 61.6 µM -1.01651278507615 0.157584783321319 no 2819 0.154692631197816 4005 24208416
SGTC_3112 9123419 49.47 µM -1.01693607534709 0.157470718646874 no 2820 0.154591920165805 4145 17015854
SGTC_3000 9075062 71.4286 µM -1.01695647441843 0.157465223048844 no 2821 0.154587067826202 4057 17057871
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.01804928259759 0.157171000049551 no 2822 0.154327268012269 4088 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2971 9092186 9.93 µM -1.01869910846381 0.156996215222147 no 2823 0.154172917989993 4120 25236400
SGTC_801 0866-0028 10.1 µM -1.0189880539864 0.156918538109644 no 2824 0.154104318951904 4120 6849771
SGTC_2132 5317594 122.667 µM -1.02131507562374 0.15629388773104 no 2825 0.153552593071183 4058 794577
SGTC_2071 5230951 39.92 µM -1.02349101287703 0.155711277341427 no 2826 0.153037873487307 4147 1799272
SGTC_3316 9136639 10.545 µM -1.02553710471238 0.155164741473116 no 2827 0.152554913514619 4126 4903665
SGTC_1067 clotrimazole 1.36 µM -1.02554758650084 0.155161944925035 no 2828 0.152552441997366 4147 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2070 5230947 200 µM -1.02604940093687 0.155028099430885 no 2829 0.152434149470909 4190 2835538
SGTC_1187 1391-0724 117 µM -1.02778898688502 0.154564702119544 no 2830 0.15202454894351 4153 6997986
SGTC_412 gemfibrozil 100 µM -1.02938130005399 0.154141339204593 no 2831 0.151650266452642 4046 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_783 0848-0141 92.7 µM -1.03003096221391 0.153968828095394 no 2832 0.151497735646459 4047 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2508 celastrol 40.54 µM -1.03233250579283 0.153358705206532 no 2833 0.150958189188173 4067 122724 Celastrol is a natural product and antioxidant.
SGTC_384 k007-0144 5.16 µM -1.03441997592447 0.152806718670672 no 2834 0.150469934876809 4074 6824886
SGTC_3200 9114385 49.47 µM -1.03452898771797 0.152777929094544 no 2835 0.150444466213318 4167 17018030 YLR208W SEC13
SGTC_1220 1838-0075 193 µM -1.03516885514998 0.15260901521295 no 2836 0.150295030492346 4039 5529645
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.03690518056321 0.152151279972334 no 2837 0.149890024666219 4104 6708739 YPR165W RHO1
SGTC_701 4424-0219 185 µM -1.03753880192564 0.151984470112848 no 2838 0.149742411029974 4181 2911779
SGTC_3016 9080866 49.47 µM -1.03858619339738 0.151708995835832 no 2839 0.14949861482877 4110 17066299
SGTC_2841 9004761 38.96 µM -1.03976215576433 0.151400101818182 no 2840 0.149225207667892 4111 2991039
SGTC_115 0527-0192 112.043 µM -1.03977700999482 0.151396202683895 no 2841 0.149221756247755 4114 4233931
SGTC_136 0097-0015 404.482 µM -1.04007932315588 0.151316862048266 no 2842 0.14915152455952 4122 4861337
SGTC_1738 st035555 74 µM -1.04040780870806 0.151230683948795 no 2843 0.14907523767845 4203 5331140
SGTC_3310 9130229 44.1445 µM -1.04121407920026 0.15101929753367 no 2844 0.148888101413141 4174 7761258
SGTC_2310 7668677 200 µM -1.04213319711447 0.150778564949248 no 2845 0.148674964678422 4156 2197143
SGTC_2116 5511452 16.8835 µM -1.04446519797473 0.150168921366671 no 2846 0.148135106325681 4170 870744
SGTC_2858 9025781 8.96 µM -1.04477325754489 0.150088509892906 no 2847 0.14806388872592 4048 4894980 YPL153C RAD53
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.04768320821759 0.149330354291474 no 2848 0.147392293275064 4119 803109
SGTC_3268 9137683 49.47 µM -1.04780701719154 0.14929815403407 no 2849 0.147363764409503 4193 1953228
SGTC_3332 9141069 11.198 µM -1.04864858305082 0.149079402312153 no 2850 0.147169943422831 4080 17332883
SGTC_2597 laccaic acid a 100 µM -1.04900455326174 0.148986937954042 no 2851 0.147088011398455 4152 5491415 A textile dye.
SGTC_2683 piperine 63.03 µM -1.05027205393816 0.148658011899467 no 2852 0.146796524966663 4123 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1664 st014217 9.02 µM -1.05035305397853 0.148637008289014 no 2853 0.146777910614787 4188 3982782
SGTC_2991 9074669 71.4286 µM -1.05081640373171 0.148516898116204 no 2854 0.146671460176694 4144 17333109
SGTC_2117 5521686 200 µM -1.05264844885003 0.148042628565069 no 2855 0.146251071751317 4091 803312
SGTC_1697 st025554 27.742 µM -1.05509394359203 0.147411133829902 no 2856 0.145691180833491 4140 1269519
SGTC_3224 9130643 49.47 µM -1.05601804609036 0.147172975470668 no 2857 0.145479985124119 4204 17644395
SGTC_2680 butyl paraben 22.24 µM -1.05715956556876 0.146879141024218 no 2858 0.145219385023577 4223 7184 An antifungal and steroid mimetic.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.05769926047492 0.146740357181631 no 2859 0.145096286261394 4192 6708784 An antioxidant flavonoid
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.06016430860238 0.146107583079021 no 2860 0.144534927701262 4157 1377
SGTC_2270 7924575 90.91 µM -1.06035930270359 0.146057606739365 no 2861 0.144490584773731 4146 1262135
SGTC_2152 5568786 200 µM -1.0619264044143 0.145656380825865 no 2862 0.144134548524257 4147 5399883
SGTC_3120 9124077 49.47 µM -1.06234565181095 0.145549166444277 no 2863 0.144039398372587 4272 18774327 YGL155W CDC43
SGTC_2635 hydroquinidine 100 µM -1.06309172959388 0.14535850281775 no 2864 0.143870177326813 4084 442912 An experimental heart treatment.
SGTC_1759 st043059 70 µM -1.06334190218759 0.145294607686475 no 2865 0.143813464663602 4158 669426
SGTC_688 0527-0193 473 µM -1.06401138566833 0.145123711749877 no 2866 0.14366177087221 4222 4007154
SGTC_1324 1418-0026 34.4 µM -1.06444370655982 0.145013427117107 no 2867 0.143563871567277 4189 1372513
SGTC_12 0849-0099 9.267 µM -1.06476575095038 0.144931310585187 no 2868 0.143490973709848 4053 6071388
SGTC_2923 7992654 58.14 µM -1.06633254537619 0.144532248012125 no 2869 0.143136671222904 4164 2985126
SGTC_1931 st074438 57.1 µM -1.06765992130043 0.144194745137692 no 2870 0.142836971730991 4129 2787313
SGTC_984 1492-0255 2.91 µM -1.06895480127412 0.143866017160387 no 2871 0.14254501825727 4134 1585198
SGTC_1287 0971-0001 34.6 µM -1.06969356749699 0.143678695077858 no 2872 0.142378631341722 4151 4665869
SGTC_2792 7535235 81.82 µM -1.07055635696107 0.143460134026317 no 2873 0.142184477963317 4170 1281891
SGTC_2727 riluzole 51.77 µM -1.07124304494781 0.143286343335645 no 2874 0.142030080778215 4185 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_816 0325-0417 81.3 µM -1.07218576384053 0.143047986636689 no 2875 0.141818301682668 4180 68101
SGTC_1438 4092-1045 4 µM -1.07270142407119 0.142917720702701 no 2876 0.141702550614838 4171 1351342
SGTC_2174 5790901 200 µM -1.0734083336197 0.142739271741895 no 2877 0.141543973531688 4166 786020
SGTC_1718 roemerine 11.9335 µM -1.07363747681787 0.14268146023846 no 2878 0.141492596928355 3902 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3351 9150312 21.596 µM -1.07418003394525 0.142544639338665 no 2879 0.141370999618666 4090 4904905
SGTC_2961 9083290 32.55 µM -1.0794119604232 0.141229816827952 no 2880 0.140202060734599 4111 17741490
SGTC_1022 4477-0945 21.3 µM -1.08056446801678 0.140941291621291 no 2881 0.139945447617889 4126 4648966
SGTC_2213 7173844 200 µM -1.08146838367185 0.140715280269619 no 2882 0.139744408547304 4134 892728
SGTC_1167 k781-0610 148 µM -1.08474145183285 0.139898954219073 no 2883 0.139018091581065 4208 4525169
SGTC_1017 4239-0030 168 µM -1.08796578349755 0.139097936342943 no 2884 0.138305106550258 4201 1149593
SGTC_1906 st060206 94.7 µM -1.08858046976151 0.138945585377261 no 2885 0.13816946655689 4206 5133468
SGTC_2399 5884133 200 µM -1.09407681541764 0.137588357455058 no 2886 0.13696064489812 4179 722445
SGTC_3266 9136860 49.47 µM -1.09415442995775 0.137569256900671 no 2887 0.136943626895674 4024 4871271 YPR165W RHO1
SGTC_620 0109-0052 432 µM -1.09555365199231 0.137225225709205 no 2888 0.13663707701988 4195 493037
SGTC_1436 4092-1007 8.32 µM -1.09561145991745 0.137211024941898 no 2889 0.136624422217503 4185 2881121
SGTC_2173 5763948 167 µM -1.09591760285601 0.137135836337095 no 2890 0.136557417459904 4168 2867177
SGTC_1515 3460-0031 42.1 µM -1.09638030017978 0.137022251453655 no 2891 0.136456190682714 4131 2876596
SGTC_2375 9072683 200 µM -1.09650546617686 0.136991536228712 no 2892 0.136428816268156 4261 16798029
SGTC_1247 0448-0043 5.84 µM -1.09856171786092 0.13648761395618 no 2893 0.135979641727787 4224 3089013 YGL099W LSG1
SGTC_1249 0481-0015 10.2 µM -1.10112063527155 0.135862276869219 no 2894 0.135422078573183 4123 4227577
SGTC_47 0149-0135 24.25 µM -1.1053177201063 0.134840865115115 no 2895 0.134510971134273 4218 5239155
SGTC_3276 9139060 49.47 µM -1.10559742333861 0.134772983664993 no 2896 0.134450402788927 4283 4870619
SGTC_1328 1441-0025 69.2 µM -1.10707445899339 0.134414909310945 no 2897 0.13413086859158 4177 4562601
SGTC_2467 5474540 200 µM -1.10708006877934 0.134413550589777 no 2898 0.134129655994999 4159 5413519
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.10788234720314 0.134219331427155 no 2899 0.133956315148126 4197 75037 A free radical scavenger.
SGTC_2618 avocadyne 43.43 µM -1.10841849508707 0.13408964584043 no 2900 0.133840560503622 4114 3015189
SGTC_218 alverine citrate 93.75 µM -1.10993074169704 0.133724321554484 no 2901 0.133514436082981 4240 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2733 amorolfine 100 µM -1.11029295104756 0.133636921706884 no 2902 0.133436404810672 4323 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1178 0988-0033 191 µM -1.11046479431936 0.133595470267818 no 2903 0.133399395345419 4244 5392207
SGTC_3041 9091929 49.47 µM -1.11272496496205 0.133051102539784 no 2904 0.132913285059577 4209 25236887
SGTC_342 k048-0088 23.3 µM -1.11310732601692 0.132959161140673 no 2905 0.132831168834161 4191 6820570
SGTC_2106 5357045 167.29 µM -1.11739155193599 0.131931979336367 no 2906 0.131913472850411 4223 668842
SGTC_2031 5180455 200 µM -1.11742729656504 0.131923432326889 no 2907 0.131905834668711 4172 29949
SGTC_1303 1160-0052 261 µM -1.12084056048878 0.131109035209081 no 2908 0.131177867834881 4154 3562476
SGTC_173 1273-0061 2.693 µM -1.13149345953386 0.128589640240714 no 2909 0.128923727365078 4196 2847414 YPL266W DIM1
SGTC_1327 1436-0082 2.18 µM -1.13218079017313 0.128428249274123 no 2910 0.128779217281158 4227 15992205
SGTC_2514 salinomycin 42.74 µM -1.13295548762781 0.128246512474129 no 2911 0.128616473226268 4277 23682228 A polyether potassium ionophore.
SGTC_2666 tannic acid 100 µM -1.13426790873698 0.12793903841471 no 2912 0.128341093041909 4214 16134267 A thiamine antagonist.
SGTC_2245 6637752 200 µM -1.13447423884493 0.127890746021057 no 2913 0.128297836868856 4279 681890
SGTC_2155 5570423 76 µM -1.13873316368575 0.126896755801775 no 2914 0.127407233012326 4196 797402
SGTC_1190 1486-1332 13 µM -1.13891158008953 0.126855232898527 no 2915 0.127370017583258 4217 4150046
SGTC_1512 0259-0544 12.2 µM -1.14018053240031 0.126560182122267 no 2916 0.127105548127217 4212 18476
SGTC_1294 1000-1494 117 µM -1.1407981269335 0.126416755039399 no 2917 0.126976970135067 4216 712797 YDL207W GLE1
SGTC_920 mycophenolic acid 780.421 nM -1.14254569985573 0.12601152114466 no 2918 0.126613630754863 4221 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1001 4048-4355 44.4 µM -1.14322362230257 0.125854565979112 no 2919 0.126472878442662 4213 21824233
SGTC_754 3474-0146 171 µM -1.1451767024863 0.125403143921926 no 2920 0.12606798355497 4217 24762078
SGTC_1883 5-benzylidenerhodanine 20 µM -1.14557259047198 0.125311778924105 no 2921 0.125986021922977 4219 1273210
SGTC_2478 5763493 32.33 µM -1.14640613484803 0.125119561365771 no 2922 0.125813572738974 4172 1365576 YLR208W SEC13
SGTC_1723 st034307 2.5525 µM -1.14994063259923 0.124306784909099 no 2923 0.125084161955498 4260 867466
SGTC_1986 st071812 45 µM -1.15305550672516 0.123593570367539 no 2924 0.124443801187366 4181 11838594
SGTC_2704 st078022 71.1 µM -1.15367571199259 0.123451904391982 no 2925 0.124316572537871 4286 54697681
SGTC_1405 3909-7894 12 µM -1.15461169397823 0.123238324790775 no 2926 0.12412473787589 4235 7104060
SGTC_1864 st057645 30.4 µM -1.15573980473249 0.122981248047819 no 2927 0.123893800726666 4286 688666
SGTC_706 4262-0057 46.9 µM -1.15660209143746 0.122785001645156 no 2928 0.123717483699326 4255 883298
SGTC_1957 st077035 62.4 µM -1.15889519505836 0.122264186960436 no 2929 0.123249453860136 4254 705593
SGTC_2145 5634607 200 µM -1.15959073079653 0.122106522337879 no 2930 0.123107738329193 4216 308662
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.16199686960793 0.121562198193994 no 2931 0.122618368247736 4247 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2436 5633522 8.09 µM -1.16221745624145 0.121512381884762 no 2932 0.122573572847898 4242 5724242
SGTC_2987 9018338 71.43 µM -1.16317136243889 0.12129712114301 no 2933 0.122379991529084 4273 5055682
SGTC_1909 st060837 51.5 µM -1.16327004278097 0.121274868017093 no 2934 0.122359978049542 4226 678937
SGTC_2869 9037858 32.47 µM -1.16741440830011 0.120342874988697 no 2935 0.121521527624461 4213 27187042
SGTC_3356 9151811 4.48 µM -1.16760098283488 0.120301036747442 no 2936 0.121483876788133 4263 1859254 YPR165W RHO1
SGTC_1445 4239-0156 97.7 µM -1.16793442242366 0.12022629040473 no 2937 0.121416608934102 4328 4008346
SGTC_778 3456-2434 196 µM -1.17009570725356 0.119742593820539 no 2938 0.120981227903661 4211 5539063
SGTC_2571 chrysanthemic acid 100 µM -1.17021757046613 0.119715361702883 no 2939 0.12095671186863 4249 2743 An insecticide.
SGTC_2111 5486399 200 µM -1.17120888336802 0.119494000593711 no 2940 0.120757412715057 4207 689674
SGTC_483 fpl-64176 144 µM -1.1713163472938 0.119470021157298 no 2941 0.120735821454542 4365 3423
SGTC_1080 nisoldipine 24.4 µM -1.17195821944281 0.119326864886307 no 2942 0.120606915429567 4257 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3115 9123671 49.47 µM -1.17452817801723 0.118754901710782 no 2943 0.120091766095559 4382 3286988
SGTC_453 enantio-paf c16 10 µM -1.174889817327 0.118674571925199 no 2944 0.120019399978927 4007 13871343 A lipid and platelet activating factor
SGTC_2952 9073731 13.78 µM -1.17590935937544 0.118448311011154 no 2945 0.11981554920608 4302 16457353
SGTC_1626 st003712 1.76 µM -1.17619538964657 0.11838488881632 no 2946 0.119758403198875 4302 24207035
SGTC_1194 1488-0194 225 µM -1.17724005778868 0.118153455938929 no 2947 0.119549852174976 4221 1391452
SGTC_2400 5203494 178.7 µM -1.17737640823859 0.118123272860915 no 2948 0.119522650935579 4174 6777674
SGTC_1362 1611-0397 101 µM -1.17779372577856 0.118030927676686 no 2949 0.119439425285601 4227 27816
SGTC_545 4218-0007 221 µM -1.18048150271741 0.117437392420108 no 2950 0.118904381523553 4252 2840508
SGTC_2470 5664817 21.68 µM -1.18169903012563 0.117169225464672 no 2951 0.118662571655281 4299 2859561
SGTC_1227 3909-8010 46.6 µM -1.18182110947613 0.117142360780465 no 2952 0.118638344980665 4250 15982272
SGTC_2778 tioconazole 65.09 nM -1.18248270581148 0.116996846327236 no 2953 0.118507111830662 4149 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1709 st033179 39.1045 µM -1.18252576400196 0.116987380358072 no 2954 0.118498574436722 4262 573381
SGTC_380 3970-0968 6 µM -1.1829341086436 0.116897636315095 no 2955 0.118417631214703 4146 2891601
SGTC_3252 9135871 49.47 µM -1.18659194627718 0.116095909963152 no 2956 0.117694307096832 4285 17682838
SGTC_1358 1509-0022 2.48 µM -1.18672089316471 0.116067718723452 no 2957 0.11766886550438 4306 3258434
SGTC_3250 9135583 49.47 µM -1.18867308158558 0.115641511653152 no 2958 0.11728416860323 4315 7699353
SGTC_499 genistein 192 µM -1.18882506440778 0.115608377058178 no 2959 0.117254256392264 4381 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2036 5160441 105 µM -1.18967960125667 0.11542220043971 no 2960 0.11708617294789 4255 134534 YIL048W NEO1
SGTC_814 3342-0569 96 µM -1.19063938357973 0.115213348310753 no 2961 0.116897591841679 4336 4346283
SGTC_11 0438-0307 1.3 µM -1.193807098068 0.114525949119502 no 2962 0.116276717234821 4274 4011476
SGTC_2323 6148992 148.28 µM -1.1943835252111 0.11440117807789 no 2963 0.116163989146622 4249 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_318 1488-0629 67.2 µM -1.19533467444046 0.114195507885651 no 2964 0.115978148732415 4335 3662576
SGTC_2485 5633444 17.78 µM -1.19619552198912 0.114009591071657 no 2965 0.115810133974438 4289 5724239
SGTC_1548 st061468 90.8 µM -1.19807358638252 0.113604735095258 no 2966 0.115444185366708 4279 390799
SGTC_845 0330-0138 4.51 µM -1.19932705299569 0.113335095179045 no 2967 0.115200399913212 4234 9039800
SGTC_3235 9132602 49.47 µM -1.1998421117224 0.113224430568873 no 2968 0.115100332828003 4284 4912240
SGTC_256 clotrimazole 625 nM -1.20039753170381 0.113105180423303 no 2969 0.114992493520023 4222 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1285 0929-0069 65.5 µM -1.20235550227314 0.112685513857244 no 2970 0.114612910793299 4320 1206237
SGTC_866 0495-0101 262 µM -1.20243389334507 0.112668734890798 no 2971 0.114597732064833 4277 635694
SGTC_1461 k072-0203 53.8 µM -1.20299603154783 0.112548466085151 no 2972 0.114488928122952 4196 5418714
SGTC_1607 st000305 50.6 µM -1.20334840392425 0.11247312320345 no 2973 0.114420762642817 4293 5457690
SGTC_2013 4024628 200 µM -1.2043186371784 0.112265857932699 no 2974 0.114233222967898 4330 5230760
SGTC_3040 9091894 49.47 µM -1.20600409145605 0.111906453379072 no 2975 0.113907956427423 4139 25236966
SGTC_2344 7990960 76.95 µM -1.20861662888472 0.111350985924375 no 2976 0.113405082414711 4266 140813
SGTC_117 lucigenin 22.078 µM -1.21145561420568 0.110749612681877 no 2977 0.112860417973455 4281 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_954 1189-0853 2.85 µM -1.21164230071852 0.110710149179228 no 2978 0.112824667381132 4219 2828194
SGTC_1964 st076914 61 µM -1.21245511751716 0.110538445980951 no 2979 0.112669106653418 4345 24208661
SGTC_2850 9015429 58.44 µM -1.21493632987425 0.110015484131059 no 2980 0.11219518808675 4307 6457570
SGTC_302 1094-0063 18.9 µM -1.21659762144926 0.109666329546993 no 2981 0.111878674082362 4268 5440289
SGTC_409 arachidonic acid 100 µM -1.21908540418368 0.10914495967564 no 2982 0.111405889554595 4289 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_459 nigericin 15.3 µM -1.22431853676122 0.108054060407185 no 2983 0.110416043414051 4375 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2786 7743617 45.45 µM -1.22512577884 0.107886483992691 no 2984 0.11026391684044 4261 583674
SGTC_2354 9060492 162 µM -1.22519440161325 0.107872247140123 no 2985 0.110250991661112 4331 6471895
SGTC_805 3852-0218 479 µM -1.22593431988142 0.107718825627953 no 2986 0.11011169621225 4270 6615355
SGTC_3296 9122258 64.045 µM -1.2259936424337 0.107706531950326 no 2987 0.110100533743269 4276 4730474
SGTC_215 1287-0124 461.5 µM -1.2269823169582 0.107501793293075 no 2988 0.109914618611817 4314 5560863
SGTC_3089 9117425 49.47 µM -1.22981475753757 0.106916793386026 no 2989 0.109383240327048 4291 9401657
SGTC_2261 9010538 184.68 µM -1.2298921749269 0.106900836243962 no 2990 0.109368742437123 4319 6457250
SGTC_2068 5226020 147 µM -1.23175747788931 0.106516882428194 no 2991 0.109019845897558 4320 1810509
SGTC_1019 4262-0212 3.4 µM -1.23554496759816 0.105740331030978 no 2992 0.108313875828335 4325 4677213
SGTC_2251 lansoprazole 556 µM -1.2360330836056 0.105640550782624 no 2993 0.108223133193419 4255 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1003 4049-0218 100 µM -1.23995764983799 0.104840767792092 no 2994 0.107495529404048 4332 295161
SGTC_2188 6126565 140.678 µM -1.24335549937979 0.104151872643318 no 2995 0.10686843052781 4224 874518
SGTC_306 1672-3436 11.6 µM -1.24483465905447 0.103853008626311 no 2996 0.106596266575162 4348 6797378
SGTC_1472 k841-0093 193 µM -1.24573301041959 0.103671800735111 no 2997 0.106431215192128 4443 X1472
SGTC_2319 6033012 152.6 µM -1.25197161198866 0.102419727770573 no 2998 0.10529010416104 4280 847246
SGTC_1745 st081495 74 µM -1.25241829085043 0.102330504011873 no 2999 0.105208742409505 4184 13842402 YBL026W LSM2
SGTC_1677 st019204 53.9 µM -1.25287632667581 0.102239070425116 no 3000 0.105125359260879 4356 3945625
SGTC_3256 9138902 49.47 µM -1.25387937997114 0.102039047473618 no 3001 0.104942925456481 4433 17228773
SGTC_2938 9059746 27.26 µM -1.25435788286629 0.101943727639723 no 3002 0.104855976871844 4327 6471769
SGTC_2689 tacrolimus 100 µM -1.25478581706319 0.101858536213427 no 3003 0.104778261300087 4345 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1434 4073-0095 163 µM -1.25589450150042 0.101638064810884 no 3004 0.104577111191492 4320 24133745
SGTC_1049 3226-0134 66 µM -1.25672629647839 0.10147288353803 no 3005 0.104426381280862 4363 5702385
SGTC_2784 7567673 72.73 µM -1.25794081039215 0.101232051665397 no 3006 0.104206581537375 4262 3471247
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.25808696649228 0.101203097761112 no 3007 0.104180153189291 4364 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_429 1112-0049 25.5 µM -1.25877934930052 0.101066016927766 no 3008 0.10405502065302 4327 2836170
SGTC_125 0133-0007 11.75 µM -1.2600135454704 0.100822001347848 no 3009 0.103832237929898 4409 26541
SGTC_2227 7312221 64.1025 µM -1.26029251624588 0.100766905012347 no 3010 0.10378192934849 4442 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3182 9108849 49.47 µM -1.26535116091553 0.0997716359492312 no 3011 0.102872737180771 4357 17133045
SGTC_3053 9095903 49.47 µM -1.26571801449318 0.0996997391744443 no 3012 0.102807028215669 4462 17174018
SGTC_2202 7226349 200 µM -1.26670192402722 0.0995070973297254 no 3013 0.10263094589727 4320 844334
SGTC_329 k048-0121 21.3 µM -1.26718209779579 0.0994131818760244 no 3014 0.102545092728315 4361 6832902
SGTC_252 miconazole 1.30953 nM -1.26763426462203 0.0993248034489661 no 3015 0.102464294832815 4239 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_755 1995-0008 37.3 µM -1.26866993547047 0.0991225925228198 no 3016 0.102279404791328 4309 689533
SGTC_1643 st009866 20.2 µM -1.2704050135661 0.0987844999017665 no 3017 0.101970199154415 4300 3156273 YOR207C RET1
SGTC_3002 9075603 71.4286 µM -1.27585781157734 0.0977274768893693 no 3018 0.101002893441128 4285 20105405
SGTC_2992 9074591 71.4286 µM -1.27752523196198 0.0974059095241414 no 3019 0.100708439100664 4295 17741321
SGTC_1904 st060225 78 µM -1.27964383971417 0.0969984497371261 no 3020 0.100335212102339 4309 66595
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.28111207968596 0.0967168064121507 no 3021 0.100077150757148 4377 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2851 9015922 71.43 µM -1.28391200541456 0.0961813797078205 no 3022 0.0995863730560105 4373 2996893
SGTC_372 0155-0182 15.9 µM -1.28452125918104 0.0960651619906817 no 3023 0.0994798149777644 4239 771486
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.28510962975679 0.0959530258660803 no 3024 0.0993769884786523 4468 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_139 0099-0334 718.624 µM -1.28563356797478 0.0958532508018245 no 3025 0.0992854879112457 4378 97690
SGTC_2706 st078239 82.5 µM -1.28627663807507 0.0957308934482455 no 3026 0.0991732663712166 4341 15434492
SGTC_264 promethazine 12.5 mM -1.28689953999432 0.0956124831041186 no 3027 0.0990646528292701 4230 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1046 2001-0062 216 µM -1.28846548056786 0.0953152822215703 no 3028 0.0987919888100846 4287 739778
SGTC_2236 dapsone 200 µM -1.28902534795158 0.0952091898498772 no 3029 0.09869463722199 4360 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3290 9121031 71.43 µM -1.29082407296906 0.0948689279680086 no 3030 0.0983823441606062 4355 17014854
SGTC_1093 fluphenazine 7.97 µM -1.29263156576821 0.0945279108920184 no 3031 0.0980692584000837 4398 6602611 An atypical antipsychotic.
SGTC_942 3253-1115 227 µM -1.29319073212655 0.0944225970307415 no 3032 0.0979725501335894 4376 46497897
SGTC_3189 9110682 49.47 µM -1.29342417944604 0.0943786549757916 no 3033 0.0979321959198124 4390 17122418
SGTC_222 nsc-310342 10.666 µM -1.29385349748741 0.0942978833224733 no 3034 0.0978580148681446 4389 432556
SGTC_1394 3474-0001 65.7 µM -1.30058467541596 0.0930381422248284 no 3035 0.0967003276568427 4335 5017666 YIL048W NEO1
SGTC_1161 k007-0610 110 µM -1.30227387328166 0.0927239700062612 no 3036 0.0964113898306262 4323 5843850
SGTC_1513 0337-0559 19 µM -1.30732303815055 0.0917895593481495 no 3037 0.095551511550836 4354 775073
SGTC_2776 terbinafine 19.92 µM -1.30927699695284 0.0914298331500867 no 3038 0.0952202693406379 4388 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_371 0195-0006 7.36 µM -1.31071930240252 0.0911649740611209 no 3039 0.094976307439108 4213 3928593
SGTC_693 4161-2696 114 µM -1.31087370505501 0.091136653938081 no 3040 0.0949502179753036 4414 805759
SGTC_3264 9137442 49.47 µM -1.31387467459879 0.0905875191107209 no 3041 0.0944441912789534 4357 17015726
SGTC_261 5-fluorouridine 15.376 µM -1.31593848582321 0.0902112988421385 no 3042 0.0940973450282507 4393 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1617 st002906 78 µM -1.31806606691271 0.0898246699565066 no 3043 0.0937407662893356 4360 5150859
SGTC_2234 tolnaftate 200 µM -1.32051699853572 0.0893808093140691 no 3044 0.093331232233799 4467 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1476 4112-3294 3.34 µM -1.32170597080744 0.0891660765517352 no 3045 0.0931330398272736 4383 704369
SGTC_970 1315-0089 19.5 µM -1.32214755401193 0.0890864228444642 no 3046 0.0930595106166135 4342 6811083 YLR033W RSC58
SGTC_3205 9113483 49.47 µM -1.32276108245721 0.0889758412141245 no 3047 0.0929574215744072 4399 17018033
SGTC_1335 1486-0900 202 µM -1.3231117901213 0.0889126760004777 no 3048 0.0928991022167224 4378 X1335
SGTC_2810 7959871 45.46 µM -1.32315255740199 0.0889053356584125 no 3049 0.0928923247600602 4344 2974535
SGTC_639 0833-0042 114 µM -1.32550355719055 0.0884827898337256 no 3050 0.0925020951938172 4400 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1659 st012954 42.1 µM -1.32603464853216 0.0883875441564126 no 3051 0.0924141104315709 4348 24207262
SGTC_592 k241-0073 46.5 µM -1.32692083210329 0.0882287865286516 no 3052 0.0922674362002789 4420 4230158
SGTC_3300 9124615 50.48 µM -1.33057339476862 0.0875766818085734 no 3053 0.0916647107739682 4429 24824903
SGTC_2178 5812956 200 µM -1.33311880062021 0.0871243726891302 no 3054 0.0912464102846753 4350 5403383
SGTC_2299 7976368 114.88 µM -1.33773978977579 0.0863077022037215 no 3055 0.0904906376927135 4418 2979718
SGTC_1818 st052136 56.3 µM -1.33955046706063 0.0859892658586928 no 3056 0.0901957683270946 4054 674169
SGTC_370 0180-0345 38.7 µM -1.34145693309257 0.0856549345254966 no 3057 0.0898860717406768 4236 3989527
SGTC_2171 5739187 198.077 µM -1.34206138979263 0.0855491361987926 no 3058 0.0897880457461814 4343 2262761
SGTC_675 1309-0189 238 µM -1.34426908826632 0.0851635530932307 no 3059 0.0894306938364983 4399 4246530
SGTC_1689 st020265 53.493 µM -1.34441135655409 0.0851387501216591 no 3060 0.0894077017342559 4397 5758320 YPR016C TIF6
SGTC_1354 1498-1681 81 µM -1.34469080718207 0.0850900466195324 no 3061 0.089362552275303 4379 5754243
SGTC_1298 1079-1278 263 µM -1.34788519395046 0.0845348018824826 no 3062 0.0888476554529622 4386 2840950
SGTC_2317 5986382 200 µM -1.3489393920408 0.0843521601266803 no 3063 0.0886782170762198 4426 877883
SGTC_614 0462-0418 107 µM -1.35153448015233 0.0839038182127086 no 3064 0.0882621412345542 4179 5188303
SGTC_2386 9075165 157.42 µM -1.35333457391071 0.0835938767734993 no 3065 0.0879743843322994 4385 16452277
SGTC_3035 9091303 49.47 µM -1.35412447113325 0.0834581435934344 no 3066 0.0878483351057802 4474 25237002
SGTC_811 0416-0114 265 µM -1.35466381992109 0.0833655589886034 no 3067 0.0877623450043863 4434 6612453
SGTC_410 α-linolenic acid 100 µM -1.36054364029014 0.0823612325189045 no 3068 0.0868289763710462 4437 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2280 7785178 200 µM -1.36064816243109 0.0823434619762411 no 3069 0.0868124517775204 4398 2954328
SGTC_2985 9022375 71.43 µM -1.36311800957843 0.081924385673854 no 3070 0.0864226608710453 4453 4939335
SGTC_2104 5389443 200 µM -1.36318621848187 0.081912835039055 no 3071 0.0864119147513667 4442 2244536
SGTC_2686 alizarin 95.37 µM -1.36365909096483 0.0818327915924954 no 3072 0.0863374425017823 4381 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1658 st012944 20 µM -1.36497597203121 0.0816101929287213 no 3073 0.0861303010800317 4248 24207260
SGTC_1488 4013-0813 75.9 µM -1.36669749564944 0.0813198845183918 no 3074 0.0858600715837575 4388 2910057
SGTC_1455 4262-0120 131 µM -1.36877828588851 0.0809700320077541 no 3075 0.0855342952092787 4478 1529587
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.36979557651656 0.0807994044554707 no 3076 0.0853753616450717 4441 16486 A toxic proline analog.
SGTC_3005 9076496 71.4286 µM -1.37232027090415 0.0803771170406149 no 3077 0.0849818789518907 4387 21368410
SGTC_1281 0884-0031 11.8 µM -1.3730969127 0.0802475497505045 no 3078 0.0848611103558831 4429 1548255
SGTC_776 4476-4378 112 µM -1.37381487058992 0.0801279131749796 no 3079 0.0847495816665903 4472 2892008
SGTC_1681 tripelennamine 100 µM -1.37586295986712 0.0797873716902521 no 3080 0.0844320323358861 4323 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2389 9091542 195.52 µM -1.37654182803274 0.0796747362959924 no 3081 0.084326973354652 4390 3626624 YOL127W RPL25
SGTC_525 k781-2675 26.7 µM -1.37740345690316 0.0795319511739929 no 3082 0.0841937723502459 4368 3651118 YDL195W SEC31
SGTC_1959 st077091 55.8 µM -1.3776653608379 0.0794885880704591 no 3083 0.084153315389121 4429 821356 YKL052C ASK1
SGTC_1880 MG-132 525 µM -1.37789058501701 0.0794513122986277 no 3084 0.0841185361144087 4378 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1623 st003709 20.3 µM -1.38197592938478 0.0787774608982475 no 3085 0.0834895460235758 4395 16192618
SGTC_1892 st058411 7.36 µM -1.38519001564658 0.0782503685051169 no 3086 0.0829971864329692 4419 3934738
SGTC_3312 9133330 71.43 µM -1.38641174649852 0.0780507144757399 no 3087 0.0828106058275363 4435 17617324
SGTC_795 0685-0265 78 µM -1.38646891290958 0.0780413818718485 no 3088 0.082801883208163 4432 302754
SGTC_963 1269-2853 151 µM -1.38649000351648 0.0780379389749727 no 3089 0.0827986653158193 4411 3668223
SGTC_1223 0764-0573 147 µM -1.391042888153 0.0772974060160879 no 3090 0.0821062108756983 4422 1609797
SGTC_304 1310-0298 97 µM -1.3919992338179 0.0771425357135564 no 3091 0.081961314984507 4186 1550234
SGTC_3098 9119039 49.47 µM -1.39244761104148 0.0770700068895187 no 3092 0.0818934477515114 4428 17161528
SGTC_260 nsc-65238 3.989 µM -1.3931761143217 0.0769522758136751 no 3093 0.0817832704198786 4416 3246252
SGTC_2266 7929956 200 µM -1.39421834256649 0.0767840824036764 no 3094 0.0816258402852189 4365 2967153
SGTC_860 0443-0016 25.1 µM -1.40295409937472 0.0753852903175165 no 3095 0.0803152634418809 4457 5337942
SGTC_1546 5-methoxyflavanone 78.7 µM -1.40337115796781 0.0753189988085952 no 3096 0.0802530945020442 4459 147795
SGTC_401 neomycin 50 µM -1.41276669049541 0.0738373277309603 no 3097 0.07886216761971 4450 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_714 4296-0578 26.1 µM -1.42482229078016 0.0719689216866103 no 3098 0.0771042885583224 4495 1589775
SGTC_480 am 92016 50 µM -1.42509002476706 0.0719278429660673 no 3099 0.077065589883952 4474 2129 K+ channel blocker.
SGTC_3257 9139206 32.98 µM -1.42625442714162 0.0717493965344107 no 3100 0.0768974570864689 4453 4910041
SGTC_509 pifithrin 175 µM -1.43194041968777 0.0708828837536358 no 3101 0.0760804366329953 4525 4817 A p53 inhibitor.
SGTC_266 formosanin C 406 nM -1.44242489801074 0.0693062168753437 no 3102 0.0745912720830532 4317 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1299 1079-1439 3.74 µM -1.44499946970854 0.0689232127390913 no 3103 0.0742290172946343 4450 323161
SGTC_2969 9091408 28.7 µM -1.44601655807113 0.0687723567628022 no 3104 0.0740862788235262 4384 4286311
SGTC_1943 st076331 65.2 µM -1.44699834380746 0.0686269785358357 no 3105 0.0739486937143717 4453 24208415
SGTC_615 k087-0205 167 µM -1.44716637969061 0.0686021203425047 no 3106 0.0739251651465697 4490 9642773
SGTC_680 0417-1641 114 µM -1.44806172375212 0.0684697857276164 no 3107 0.0737998945271276 4488 2835990
SGTC_2217 6934799 96.0675 µM -1.44899913351241 0.0683314447955892 no 3108 0.0736689122790467 4438 675606
SGTC_2541 muurolladie-3-one 83.07 µM -1.44972541197153 0.0682244105379618 no 3109 0.0735675531963558 4419 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_303 1348-1668 34.2 µM -1.45135233861324 0.0679851141621271 no 3110 0.0733408870775824 4474 5380509
SGTC_764 1951-2361 146 µM -1.45158497648732 0.0679509496634371 no 3111 0.0733085192843168 4469 5438930
SGTC_573 3702-0553 84.7 µM -1.45259502189717 0.0678027711426826 no 3112 0.0731681145234798 4414 1222756
SGTC_484 loperamide 105 µM -1.45597762066272 0.0673083446697057 no 3113 0.0726994031339849 4563 3955 An opioid-receptor agonist.
SGTC_2314 7727897 200 µM -1.45616524967665 0.0672810011833383 no 3114 0.072673471693797 4442 900724
SGTC_1949 st076024 69.1 µM -1.45780486131339 0.0670424231394883 no 3115 0.0724471689782113 4430 2921930
SGTC_1439 4092-1168 46 µM -1.46189618006257 0.0664499534001539 no 3116 0.0718848309661873 4477 2886240
SGTC_1778 st046819 58.9 µM -1.46551097983629 0.0659298692214909 no 3117 0.0713907794728702 4526 671715
SGTC_43 0570-0105 72.5 µM -1.46564352742958 0.0659108588823451 no 3118 0.0713727132347348 4445 1114046 YDL195W SEC31
SGTC_1448 4255-0083 152 µM -1.46719329829116 0.0656889015663002 no 3119 0.0711617397482998 4496 5399660
SGTC_2468 5987765 72.9 µM -1.46751159350567 0.0656433873126189 no 3120 0.0711184688994713 4516 26772094
SGTC_486 niguldipine 82 µM -1.46754319784223 0.0656388694220087 no 3121 0.0711141735303987 4548 1236 A calcium channel blocker.
SGTC_2427 5545055 42.75 µM -1.46809764133211 0.0655596500425904 no 3122 0.0710388510993718 4410 5372858
SGTC_1026 k007-1105 30.6 µM -1.47216736054754 0.0649804323467081 no 3123 0.0704878445087558 4444 7066794
SGTC_2567 aureobasidin a 60 nM -1.47431146067303 0.0646768777586817 no 3124 0.0701988754174413 4558 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1813 st051246 8.6015 µM -1.47546417799969 0.0645141356848398 no 3125 0.0700438960772549 4431 5291959
SGTC_2553 4-methylesculetin 85.09 µM -1.47794190562974 0.0641654039355712 no 3126 0.0697116642590487 4499 5319502
SGTC_834 0312-0008 75.7 µM -1.47813013435802 0.0641389713857165 no 3127 0.069686474838335 4503 6385573 YIL048W NEO1
SGTC_2999 9069765 71.4286 µM -1.48161050905416 0.0636517536976035 no 3128 0.0692219805688839 4433 2097066
SGTC_2753 fluvastatin 17.09 µM -1.48199761865506 0.0635977406548333 no 3129 0.0691704642982797 4469 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1495 4469-0029 237 µM -1.49016380642987 0.0624666122859064 no 3130 0.0680905852205563 4492 793680
SGTC_1684 st024538 14.6195 µM -1.49033424612452 0.0624431722697757 no 3131 0.0680681860948929 4449 6732859
SGTC_721 1187-1332 279 µM -1.49131676385533 0.0623081834978026 no 3132 0.0679391748509367 4487 25730
SGTC_857 0438-0306 1.35 µM -1.4951125891272 0.0617888096119446 no 3133 0.0674425304399773 4533 4686136
SGTC_1056 3448-1962 115 µM -1.49749539841954 0.061464505981753 no 3134 0.0671322010180919 4455 715507
SGTC_2096 5468907 200 µM -1.49812613527218 0.0613788847492493 no 3135 0.0670502409885307 4488 759785
SGTC_2157 5649910 96.377 µM -1.50148706795446 0.0609242151080229 no 3136 0.0666148145226438 4488 2858091
SGTC_1431 4049-0260 9.09 µM -1.50610785384371 0.0603034154230363 no 3137 0.0660197443934385 4529 3854841
SGTC_2566 crystal violet carbinol 226 nM -1.50889415274431 0.0599314775633106 no 3138 0.0656629171773017 4457 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_678 1218-2179 85.9 µM -1.50923108192257 0.059886623546139 no 3139 0.0656198698891433 4540 6820081 YOR116C RPO31
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.51186541752238 0.0595368310439452 no 3140 0.0652840516310992 4590 16725076
SGTC_2883 9059145 45.46 µM -1.51312108289708 0.0593706657305448 no 3141 0.0651244526141479 4489 16476510
SGTC_1481 3346-2004 36 µM -1.51540905683293 0.0590688275195351 no 3142 0.0648344226162459 4587 2770522
SGTC_2780 5215298 71.43 µM -1.5167323562179 0.0588948030495254 no 3143 0.0646671358004778 4513 2834131
SGTC_2875 9039966 71.43 µM -1.51712737023002 0.0588429335841168 no 3144 0.0646172645542757 4487 6463691
SGTC_2100 5377183 190 µM -1.52217915007734 0.0581827384482959 no 3145 0.0639820989565388 4532 2844202
SGTC_198 3454-2873 16.191 µM -1.52335643808064 0.058029723074218 no 3146 0.0638347771380009 4506 710957
SGTC_3241 9133421 49.47 µM -1.52464305682898 0.0578628595377707 no 3147 0.0636740759165107 4593 17018221
SGTC_2964 9083345 53.42 µM -1.52893908950073 0.0573084316881972 no 3148 0.0631397723034551 4477 17741579
SGTC_787 4152-0075 138 µM -1.53100292379976 0.0570435726539873 no 3149 0.0628843350219211 4536 9566539
SGTC_3274 9138298 49.47 µM -1.53278933237132 0.0568150955489137 no 3150 0.0626638849427378 4484 17015756
SGTC_1185 1319-0113 81.3 µM -1.53657651590512 0.0563331083982266 no 3151 0.0621985235330751 4566 4672763
SGTC_2294 7971431 200 µM -1.53758287864077 0.0562055742166964 no 3152 0.0620753181943089 4509 5741572
SGTC_1863 st057641 20.1 µM -1.54274794885638 0.055554594923815 no 3153 0.0614459715447231 4561 3921635
SGTC_298 1391-0729 10 µM -1.54283684849021 0.0555434427884978 no 3154 0.0614351832114453 4470 3237558
SGTC_2222 6885208 172.143 µM -1.54546829172291 0.0552141374705222 no 3155 0.0611165164191288 4538 609514
SGTC_3087 9117406 49.47 µM -1.54576209110027 0.0551774665905787 no 3156 0.0610810177411307 4519 42546093
SGTC_82 0054-0107 293.755 µM -1.54826819544884 0.0548654459744319 no 3157 0.0607788692228978 4486 3104697
SGTC_1889 st059080 5.18 µM -1.5541911900817 0.0541335505142253 no 3158 0.0600694091693715 4489 176925 Isolated from Daphnopsis sellowiana.
SGTC_2897 9048598 12.99 µM -1.55599513165514 0.0539121818547741 no 3159 0.059854625012466 4507 6467404
SGTC_2101 5377231 179.231 µM -1.55613852686483 0.0538946160681957 no 3160 0.0598375776755009 4549 2844213
SGTC_2809 7964133 12.99 µM -1.56010172170277 0.0534109191710476 no 3161 0.0593679223871502 4502 1253665
SGTC_1297 1068-0111 14.1 µM -1.56060881222284 0.053349279209794 no 3162 0.0593080391432871 4520 767057
SGTC_1175 0741-0056 27.6 µM -1.56104281864933 0.0532965678564661 no 3163 0.0592568241561575 4587 765927
SGTC_86 0417-1630 471.922 µM -1.56612337902595 0.0526825842972005 no 3164 0.0586598679154654 4520 3634867
SGTC_521 r062-0005 13.8 µM -1.56648037233753 0.052639653730629 no 3165 0.0586181000306598 4459 2832033
SGTC_55 0767-0285 6.563 µM -1.56806778803727 0.0524490936508776 no 3166 0.0584326565358742 4454 3116166
SGTC_3078 9116413 49.47 µM -1.58836526412659 0.0500604640963081 no 3167 0.0561018836975771 4486 17177322
SGTC_2425 5628681 7.85 µM -1.59155451244739 0.0496931611197681 no 3168 0.0557424188384534 4578 5714958
SGTC_1153 4055-0057 267 µM -1.60962726504017 0.0476521800182591 no 3169 0.0537396261547421 4582 882706
SGTC_1653 st012112 65 µM -1.61163986057439 0.0474291104804804 no 3170 0.0535201657171285 4525 720429
SGTC_642 0335-0876 158 µM -1.61550192434451 0.0470033955823232 no 3171 0.0531010219729455 4591 6812350
SGTC_752 1896-0090 130 µM -1.61992870555061 0.0465192066516251 no 3172 0.0526237963534552 4551 772567
SGTC_96 0929-0093 37.281 µM -1.62442734196678 0.0460312677414008 no 3173 0.0521423178027948 4558 6991579
SGTC_3019 9081971 49.47 µM -1.6260758678002 0.0458534951659026 no 3174 0.0519667584819452 4547 16451803
SGTC_1491 4138-0063 26.5 µM -1.6266994626184 0.0457863923762352 no 3175 0.0519004714751318 4576 23883227
SGTC_1286 0929-0070 131 µM -1.6362464625658 0.0447688943230672 no 3176 0.0508940079490178 4606 1420408
SGTC_1002 4049-0206 172 µM -1.63661992433278 0.044729464678215 no 3177 0.0508549549249818 4532 4662749
SGTC_1777 st045864 34.765 µM -1.63907355048976 0.0444711087250119 no 3178 0.0505989713724168 4579 4691462
SGTC_1225 1216-0074 20.6 µM -1.64151197813558 0.0442155456081667 no 3179 0.0503455913536049 4563 4241466
SGTC_1710 st031758 61.5 µM -1.64986196421421 0.0433493684577375 no 3180 0.0494855858604947 4594 5394341
SGTC_554 4483-2211 187 µM -1.64992760026794 0.043342614435847 no 3181 0.0494788724290338 4609 747107
SGTC_2596 sinensetin 100 µM -1.65822699926938 0.042495419721579 no 3182 0.0486358285784889 4569 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.66939174465398 0.0413769126400273 no 3183 0.0475198843169404 4531 6857784
SGTC_1474 0330-0125 5.35 µM -1.67418026721296 0.0409045569275196 no 3184 0.0470475881992587 4636 X1474
SGTC_796 1234-0020 70.7 µM -1.67679167034682 0.0406488084465409 no 3185 0.0467916135739784 4543 46495034
SGTC_2216 7189485 200 µM -1.6776356823 0.0405664279521363 no 3186 0.046709121243955 4608 731273
SGTC_1129 3453-1384 223 µM -1.67764925061502 0.0405651047130489 no 3187 0.0467077960529004 4563 1084452
SGTC_1951 sophoraflavanone G 9.2 µM -1.67876649086008 0.0404562669142267 no 3188 0.0465987808237842 4522 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3298 9116858 71.43 µM -1.67998138121703 0.0403381855737783 no 3189 0.0464804691695082 4629 2506942
SGTC_1827 berberine 7.24 µM -1.68174358496623 0.0401674056561756 no 3190 0.0463092862320366 4493 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1690 st023502 41.2 µM -1.68942002994611 0.0394303006283574 no 3191 0.0455694825929504 4595 24207482
SGTC_2058 5236698 133 µM -1.68988153509487 0.0393863391391594 no 3192 0.0455253104292443 4552 766665
SGTC_2662 daunorubicin 22.37 µM -1.69737343179128 0.0386782471685526 no 3193 0.044813041118778 4472 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1688 st021091 57.6 µM -1.70065592346646 0.0383712892326216 no 3194 0.0445038081471041 4629 3656366
SGTC_966 1300-0360 30.2 µM -1.70155120421187 0.0382879137902366 no 3195 0.0444197656815252 4578 70588
SGTC_662 k832-1615 104 µM -1.70460784892047 0.0380043679138114 no 3196 0.0441337932643779 4617 5878478
SGTC_1786 berberine 21.6 µM -1.70523231381408 0.0379466514554728 no 3197 0.0440755528005088 4496 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_794 k038-0031 316 µM -1.70588202714066 0.0378866773314706 no 3198 0.0440150233459321 4565 6624242
SGTC_1670 st016595 4.04 µM -1.70662226926202 0.0378184409093347 no 3199 0.0439461416392438 4626 597879
SGTC_3258 9138477 49.47 µM -1.71356001457473 0.0371837741173905 no 3200 0.043304781212441 4626 4970355
SGTC_1789 tunicamycin 25 nM -1.72412789595934 0.0362337708941814 no 3201 0.0423423785682454 4516 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3191 9110352 49.47 µM -1.73473367397323 0.0353004315195248 no 3202 0.0413939944530492 4556 17122424
SGTC_1165 k072-0275 30.3 µM -1.7380700378398 0.0350109321320179 no 3203 0.0410992367925053 4605 6153523 YGL055W OLE1
SGTC_217 ketoconazole 989 nM -1.74562697211076 0.0343624111437874 no 3204 0.0404378961397623 4411 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_472 calcifediol 10 µM -1.7531650285359 0.0337253778337892 no 3205 0.0397868419879956 4642 5283731 A vitamin D metabolite.
SGTC_1395 3486-0190 4.35 µM -1.75390920511581 0.0336630187295679 no 3206 0.039723033026048 4590 6748079
SGTC_2653 dihydrofissinolide 100 µM -1.75530490930282 0.0335463200177159 no 3207 0.039603583604234 4689 6857746
SGTC_172 1112-0046 2.638 µM -1.75750114311024 0.0333633612414231 no 3208 0.0394162135881913 4603 2802135 YIL048W NEO1
SGTC_690 glyoxal 20.3 µM -1.76012406330556 0.0331459345173349 no 3209 0.0391933868000795 4413 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_552 k242-0005 476 µM -1.76069568435336 0.0330987052951559 no 3210 0.0391449617956183 4656 4088318
SGTC_2428 5615643 7.78 µM -1.7637997527353 0.032843203991304 no 3211 0.0388828495808622 4606 2253075
SGTC_526 4469-0568 170 µM -1.76401309194424 0.0328257035435056 no 3212 0.0388648875170724 4581 2901964
SGTC_2240 6690706 185.951 µM -1.76430831662273 0.0328014986215133 no 3213 0.0388400422650785 4511 805876
SGTC_1679 SEC14.276 6.7 µM -1.76446286235801 0.0327888335728631 no 3214 0.0388270413039401 4564 1005053 YMR079W SEC14
SGTC_1315 1237-0019 3.69 µM -1.7667822081263 0.0325992465836922 no 3215 0.0386323547399176 4623 825140
SGTC_3062 9077494 49.47 µM -1.76747317335098 0.0325429411013161 no 3216 0.0385745089388585 4541 16459633
SGTC_1199 1638-0010 4.46 µM -1.76749424004118 0.0325412256765043 no 3217 0.0385727464000582 4602 3111136
SGTC_90 0870-0863 4.608 µM -1.77493479463294 0.0319400024642614 no 3218 0.0379543271469786 4639 1738164
SGTC_952 1185-0122 232 µM -1.77608979963655 0.0318475017281668 no 3219 0.0378590586124906 4579 678600
SGTC_95 0471-0001 561.058 µM -1.7849248846749 0.0311472239884716 no 3220 0.0371367508316056 4590 4015405
SGTC_2417 cerulenin 830 nM -1.79559357980754 0.0303186395753082 no 3221 0.0362795888519102 4612 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_416 estradiol valerate 100 µM -1.79638091798373 0.0302582216127047 no 3222 0.0362169782712342 4616 13791 A steroid.
SGTC_560 2332-1943 155 µM -1.79801725941299 0.0301329728710743 no 3223 0.0360871363621639 4624 21177716
SGTC_223 busulfan 5 mM -1.80918526455559 0.0292895821754267 no 3224 0.03521111304844 4638 2478 A DNA alkylator.
SGTC_200 k038-0079 37.545 µM -1.8162752652319 0.0287643995993896 no 3225 0.0346640787719869 4649 3436683
SGTC_1612 st002233 45.4 µM -1.81675919374353 0.028728840503016 no 3226 0.0346269967874646 4651 1035021
SGTC_196 k015-0023 18.111 µM -1.81801680686729 0.0286366019053533 no 3227 0.0345307820151825 4592 5211998
SGTC_514 4466-0038 2.65 nM -1.82218642040487 0.0283325453732261 no 3228 0.0342133521700035 4442 5722064
SGTC_2624 nerol 100 µM -1.82601816159645 0.0280555007994383 no 3229 0.0339237631038994 4555 637566 A natural product oil.
SGTC_658 3253-0951 102 µM -1.82978633359132 0.0277852561528763 no 3230 0.0336409475818873 4642 1184878
SGTC_75 0159-0059 199.013 µM -1.83341033449462 0.0275274006381944 no 3231 0.0333707859428002 4643 5377270
SGTC_2865 9030313 51.95 µM -1.83451434116594 0.0274492457491097 no 3232 0.033288840480818 4612 42562754
SGTC_574 1315-0397 40 µM -1.83611819523534 0.0273360353487723 no 3233 0.0331700889156025 4622 6794277
SGTC_414 piperonyl butoxide 100 µM -1.84078562149971 0.0270087917934091 no 3234 0.0328264903570505 4640 5794 A potent inhibitor of cytochrome P450.
SGTC_2367 9070478 135.38 µM -1.84516606000448 0.02670465019204 no 3235 0.0325066930045766 4582 572802
SGTC_1082 camptothecin 424.86 nM -1.84548781188898 0.0266824236088838 no 3236 0.0324833049259911 4519 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.85646714026799 0.0259331816554303 no 3237 0.0316935012608192 4660 688664
SGTC_524 r073-0010 27.8 µM -1.85943623960228 0.0257336173966226 no 3238 0.0314826645276015 4600 2772106
SGTC_289 k017-0060 526 µM -1.85944207339778 0.0257332265542943 no 3239 0.0314822514119528 4644 5512909
SGTC_382 3229-0966 23.2 µM -1.862637239145 0.0255199077833688 no 3240 0.0312566606756884 4668 5722370
SGTC_1845 st056753 3.01 µM -1.86635375675286 0.0252736469421063 no 3241 0.0309959441931886 4623 5375839
SGTC_2560 caryophyllene 100 µM -1.87042602617272 0.0250061027709268 no 3242 0.0307123403021517 4674 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2206 7254556 146.969 µM -1.87184219088584 0.0249136203084263 no 3243 0.0306142196525293 4667 4398905
SGTC_750 4073-0104 132 µM -1.87583211373811 0.0246546000279908 no 3244 0.0303391683952847 4348 22330957
SGTC_3212 9128307 49.47 µM -1.877268540776 0.0245619040169872 no 3245 0.030240648825767 4552 27243542
SGTC_2006 4011487 200 µM -1.87916034220557 0.0244402680464901 no 3246 0.0301113014150142 4590 45595294
SGTC_1849 st056239 19.2 µM -1.88131061153444 0.0243026279332373 no 3247 0.0299648391800365 4653 5393181
SGTC_1685 st024049 53.0905 µM -1.88249925525265 0.0242268218430545 no 3248 0.0298841304514161 4681 1941139
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.88467785334868 0.0240883966690789 no 3249 0.0297366720777621 4715 688801
SGTC_997 3996-0078 137 µM -1.90321414000976 0.0229372883188245 no 3250 0.0285063044172378 4693 735687
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.90982827474011 0.0225379261942079 no 3251 0.0280776637440925 4706 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2328 6201408 200 µM -1.92636281450788 0.0215651440138592 no 3252 0.027029543582339 4609 2890418
SGTC_1865 st057639 52.2 µM -1.9308972902459 0.021304650162917 no 3253 0.0267478776843539 4674 688818
SGTC_613 3914-0030 117 µM -1.93689338895137 0.0209642797803384 no 3254 0.0263791883784016 4436 1145395
SGTC_1972 st070201 17.4 µM -1.93908860345921 0.0208408240084767 no 3255 0.0262452750864053 4673 2829099
SGTC_428 3448-4153 16.5 µM -1.94168655730455 0.0206955144973848 no 3256 0.0260875285263354 4659 3834874
SGTC_1857 st056007 79.3 µM -1.94739643448432 0.0203791610295004 no 3257 0.0257436126014599 4663 619834
SGTC_1014 4130-3005 69.3 µM -1.96248771908665 0.019562704794556 no 3258 0.024852864512245 4675 743608
SGTC_2429 5902844 64.44 µM -1.97364511389248 0.0189770881689621 no 3259 0.0242110550776375 4667 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_148 3253-0744 288.01 µM -1.97504013592366 0.0189049273292492 no 3260 0.0241317967261609 4586 6893655
SGTC_373 0844-0104 25.9 µM -1.98404036311288 0.01844495781858 no 3261 0.0236256702368374 4692 5375804
SGTC_1852 st056254 31.4 µM -1.99523931583198 0.0178859584202989 no 3262 0.0230083924601096 4669 442583
SGTC_922 1866-0035 480 µM -1.99595073303122 0.0178509411952904 no 3263 0.0229696428453236 4619 3156169
SGTC_2864 9034755 47.6 µM -2.0000498157293 0.0176503141698485 no 3264 0.0227474424827876 4649 4930451
SGTC_2889 9059656 51.95 µM -2.00615013776918 0.0173553021752997 no 3265 0.0224201159573139 4708 3949838
SGTC_1962 st076595 64.5 µM -2.00734364331917 0.0172980794185235 no 3266 0.0223565425536787 4652 279619
SGTC_769 0302-0231 76 µM -2.01624173528214 0.016876517718587 no 3267 0.0218873521077975 4621 571869 YER009W NTF2
SGTC_2610 ononetin 44.17 µM -2.01629480134414 0.0168740302182318 no 3268 0.0218845791066163 4653 259632
SGTC_3222 9128301 49.47 µM -2.02181718192474 0.0166168739977609 no 3269 0.0215976210277516 4636 4911358
SGTC_2305 7443522 69.23 µM -2.02291793981739 0.0165660187415487 no 3270 0.0215408043126711 4621 5415886
SGTC_421 streptovitacin 30 mM -2.02637897393063 0.0164069851904789 no 3271 0.0213629819611546 4670 91467 include heat shock
SGTC_1814 st052110 31.539 µM -2.03918672320196 0.0158297918737696 no 3272 0.0207156977335893 4645 674163
SGTC_2009 4012297 12.05 µM -2.04862905155366 0.0154154955314306 no 3273 0.0202492008120874 4644 45595307
SGTC_2614 arthonioic acid 13.39 µM -2.06313487614458 0.014797176067766 no 3274 0.0195499077070564 4588 6710684
SGTC_1824 st053723 68.6 µM -2.06788645802418 0.014599330135232 no 3275 0.0193253505548123 4699 675225
SGTC_1675 st018485 24.5 µM -2.07025113470769 0.0145017211380819 no 3276 0.0192144164946841 4686 3323024
SGTC_1886 st057356 49.9 µM -2.0737925524116 0.014356589457372 no 3277 0.0190492905745874 4694 24207747
SGTC_1006 4099-6547 255 µM -2.09437728691952 0.013537528580895 no 3278 0.018113192216192 4717 3146833
SGTC_3070 9117005 49.47 µM -2.09937480599067 0.0133448741934686 no 3279 0.01789193690099 4746 8779016
SGTC_2418 pentamidine 31.67 µM -2.10377984389226 0.0131770279719656 no 3280 0.0176988279108268 4658 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2414 st077232 92.9 µM -2.10838757249998 0.013003413664298 no 3281 0.0174987392609346 4653 729801
SGTC_1978 st071761 42 µM -2.10898748535621 0.0129809557332536 no 3282 0.0174728309351426 4723 5147680
SGTC_3198 9112019 49.47 µM -2.12067231372595 0.0125501706637402 no 3283 0.0169746939905728 4719 45595555
SGTC_1665 st014639 11.4 µM -2.12076680605961 0.012546738076882 no 3284 0.0169707156911466 4755 981133 YIL048W NEO1
SGTC_3074 9116018 49.47 µM -2.12289813137388 0.0124695298702619 no 3285 0.0168811945424644 4722 17027303
SGTC_947 3447-0010 211 µM -2.12478126085295 0.0124016553470851 no 3286 0.0168024345824136 4662 748350
SGTC_1984 st072354 53.1 µM -2.12919617907536 0.0122437796687179 no 3287 0.0166190164520962 4644 5762938
SGTC_749 1000-0129 128 µM -2.13692446125906 0.0119716097748307 no 3288 0.0163020680389495 4723 708470
SGTC_254 nsc-64875 3.808 µM -2.14942739865087 0.0115423971104137 no 3289 0.0158002677426619 4709 56993
SGTC_2016 5121758 140 µM -2.16679513084487 0.010968388044386 no 3290 0.0151252394468648 4651 2795203
SGTC_2007 4011539 71.82 µM -2.16702408118247 0.0109609900846372 no 3291 0.0151165089876693 4699 45595301
SGTC_2818 7996756 12.99 µM -2.17196307464953 0.0108024524703469 no 3292 0.0149292241077235 4711 2241621
SGTC_3348 9149464 3.537 µM -2.18341718769192 0.010442447215428 no 3293 0.0145025506722137 4691 1951442
SGTC_733 4069-0007 56.1 µM -2.19279625677255 0.0101554926092732 no 3294 0.0141610308820227 4711 5717425 YNL287W SEC21
SGTC_3146 9095609 49.47 µM -2.19857724270113 0.00998206972288886 no 3295 0.0139539983047399 4721 17173999
SGTC_3175 9106517 49.47 µM -2.21713802728146 0.00944262255184812 no 3296 0.0133068304524037 4729 41468073
SGTC_1588 farnesol 29.9 µM -2.24311585496955 0.0087304875328574 no 3297 0.0124446722582438 4737 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_804 1595-0054 20.9 µM -2.26535765727521 0.00815864243762119 no 3298 0.0117453702531592 4729 761523 Stimulates phospholipase C.
SGTC_2224 6650123 117.647 µM -2.26805061926669 0.00809168950610323 no 3299 0.0116630608076114 4789 2908370
SGTC_3066 9117245 49.47 µM -2.28270198001531 0.0077358187789876 no 3300 0.0112239645429199 4748 17176980
SGTC_2979 9012552 45.46 µM -2.28457916251422 0.00769123373008137 no 3301 0.0111687579591591 4734 17100905
SGTC_2082 5219693 150 µM -2.28872991207715 0.00759345128612672 no 3302 0.0110475249692573 4714 2834649
SGTC_1870 st057514 26.5 µM -2.31399600983921 0.00702151499896818 no 3303 0.0103339705076319 4740 5393161
SGTC_719 2810-4230 27.3 µM -2.32117687647713 0.00686606256077902 no 3304 0.0101386498210978 4757 721079
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.32626449533111 0.00675777243176014 no 3305 0.0100022224367597 4770 97141
SGTC_555 4296-0685 37 µM -2.34648505704327 0.00634214984806485 no 3306 0.00947571305655794 4744 2908540 YHR072W ERG7
SGTC_2001 4023502 57.655 µM -2.34961252182788 0.00627992846405888 no 3307 0.00939648149454136 4728 108941 YCR052W RSC6
SGTC_2675 theaflavin digallate 100 µM -2.35429658378599 0.00618774918413899 no 3308 0.00927889884900662 4704 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1197 1601-0112 267 µM -2.35947507509975 0.00608723655262374 no 3309 0.00915040510859081 4736 7350313
SGTC_3148 9097893 49.47 µM -2.36189891568162 0.00604068976986893 no 3310 0.00909079950321638 4716 17174100
SGTC_1901 st060216 58.6 µM -2.36914540508628 0.0059034060594788 no 3311 0.00891462123201535 4742 688792
SGTC_686 1319-0111 510 µM -2.39227425088857 0.00548356033044558 no 3312 0.00837216266185949 4750 4562600
SGTC_2256 7954252 200 µM -2.39575696953006 0.00542269374917847 no 3313 0.00829304176888557 4757 2972920
SGTC_1707 st032323 6.317 µM -2.40794265699373 0.00521442699236679 no 3314 0.0080213503065984 4599 3132057 YMR211W DML1
SGTC_1131 3454-3128 32.3 µM -2.43182860395036 0.00482673146754342 no 3315 0.00751140716366849 4711 710982
SGTC_3221 9128209 49.47 µM -2.44557109936446 0.0046155132006511 no 3316 0.00723114650922045 4758 16460723
SGTC_69 0096-0274 206.684 µM -2.44892428753965 0.00456524429548054 no 3317 0.00716417816496759 4742 6741392
SGTC_2168 5727979 200 µM -2.46524421190532 0.00432749758641307 no 3318 0.00684599479385791 4730 695210
SGTC_1193 1488-0126 41.5 µM -2.48357104283393 0.00407375759377647 no 3319 0.00650361931103302 4751 1384710
SGTC_821 1114-0266 29.2 µM -2.49693722066006 0.0038971843891554 no 3320 0.00626355661641397 4770 3123235
SGTC_299 1273-0059 1.44 µM -2.50003574248126 0.00385724362930175 no 3321 0.00620903884881466 4565 2848077
SGTC_1994 st072947 40.9 µM -2.51013791921788 0.00372955914544741 no 3322 0.00603420080488186 4772 5286565 YDL195W SEC31
SGTC_3213 9129884 49.47 µM -2.52963613644753 0.0034937850250912 no 3323 0.00570904345806846 4733 17190742
SGTC_1477 0139-0234 16 µM -2.53780057776356 0.00339910123977166 no 3324 0.00557757647486203 4767 620880
SGTC_197 4544-0043 41.561 µM -2.55547534815951 0.0032019814747326 no 3325 0.00530214361161847 4774 896523
SGTC_58 0957-0393 9 µM -2.5698052198082 0.00304978269898015 no 3326 0.00508778549686416 4345 6997992
SGTC_553 k007-0256 45.7 µM -2.57407904863813 0.00300566876812111 no 3327 0.00502536535839897 4784 6287000
SGTC_2359 9039622 200 µM -2.59735453038307 0.00277535901217682 no 3328 0.00469724517652678 4754 6463596
SGTC_2365 9042475 200 µM -2.61640694129319 0.00259882424482095 no 3329 0.0044430291336196 4760 6464479
SGTC_208 k072-0098 12.366 µM -2.64228435273666 0.00237530048105575 no 3330 0.00411744434755753 4779 5948901
SGTC_2694 st077685 81.9 µM -2.66473718233474 0.00219561757702519 no 3331 0.00385242559582226 4722 2838096
SGTC_2085 5307070 144.047 µM -2.67337705887649 0.00212982380314819 no 3332 0.003754589740392 4753 2840351
SGTC_2449 5812982 45.77 µM -2.70761986927303 0.00188628201508968 no 3333 0.00338837966278967 4737 776185
SGTC_2507 purpurin 79.67 µM -2.72664607916771 0.00176217658628954 no 3334 0.00319908124269322 4765 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1900 st060200 72.8 µM -2.7408605676954 0.00167435752391161 no 3335 0.00306392528015997 4774 688945
SGTC_660 4031-1742 102 µM -2.80829146720085 0.00130960669349528 no 3336 0.00249025634543675 4721 6738706
SGTC_191 3914-0123 66.505 µM -2.80959632988168 0.00130332681821612 no 3337 0.00248018361181494 4802 3144412
SGTC_2582 agaric acid 100 µM -2.8203787563182 0.00125247876228947 no 3338 0.00239834980205721 4573 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1463 k081-0032 34.1 µM -2.83043377803075 0.00120670295191136 no 3339 0.00232424665088707 4415 977755
SGTC_2366 9070441 60.58 µM -2.85232253937547 0.00111230283793352 no 3340 0.00217005191059542 4768 6837235
SGTC_225 nsc-122657 1.016 µM -2.8638462207799 0.00106537042034072 no 3341 0.00209265573108718 4795 275685
SGTC_2997 9067075 71.4286 µM -2.9747205754503 0.00069810888841964 yes 3342 0.00146627769336437 4776 27209819
SGTC_792 4534-1957 155 µM -3.14218912226674 0.000358742727412218 yes 3343 0.000838448414860563 4783 1717904
SGTC_228 caffeine 993.056 µM -3.18553624528503 0.000300337902240528 yes 3344 0.000722430018242368 4799 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2993 9054257 71.4286 µM -3.2217199583893 0.000258496179578758 yes 3345 0.000637118063956938 4773 6470217 YGL055W OLE1
SGTC_310 1273-0058 1.06 µM -3.27532016285206 0.000206396895184965 yes 3346 0.000527711437986317 4542 2734232
SGTC_1848 st056003 16.4 µM -3.30609228145732 0.000181099768884248 yes 3347 0.0004730346203362 4792 146492
SGTC_226 1,3-diallylurea 8.28947 mM -3.32868205080984 0.000164407793848405 yes 3348 0.000436289781430568 4802 74537 YKL182W FAS1
SGTC_557 1315-0110 16.2 µM -3.55320046038388 6.08488213677579e-05 yes 3349 0.000190287168795017 4802 6833801
SGTC_1462 k081-0014 26.5 µM -3.72261456538281 2.76244680551211e-05 yes 3350 9.85851975120273e-05 4514 3270634
SGTC_2419 paclitaxel 166.5 µM -3.72844033894465 2.68680362289283e-05 yes 3351 9.63342542591664e-05 4793 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1995 st072814 61.1 µM -4.04753869304194 5.51863939933776e-06 yes 3352 2.58795139282417e-05 4807 5769371
SGTC_1993 st073995 70.8 µM -4.46595078901681 5.7536400798444e-07 yes 3353 3.98569665978111e-06 4808 3098394
SGTC_1990 st072050 59.8 µM -4.99773907449394 2.39485837052915e-08 yes 3354 2.90032002332155e-07 4809 17233948
SGTC_2088 5278280 127.392 µM -5.69512805635516 2.19852099478206e-10 yes 3355 6.1639678688285e-09 4810 791502
SGTC_77 0828-0286 12.516 µM -6.15074179230626 7.44256219092709e-12 yes 3356 3.85606933861506e-10 4808 745345