SGTCid condition conc unit FBP26|YJL155C.score FBP26|YJL155C.strain.pval FBP26|YJL155C.strain.significant FBP26|YJL155C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_142 0335-0849 62.6745 µM 18.2789565934755 2.14366071547562e-74 yes 1 6.08663277918321e-75 9 3889043 YPR107C YTH1
SGTC_137 0438-0332 85.389 µM 16.8335559660456 1.96239742287273e-63 yes 2 6.92634008268595e-64 9 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1294 1000-1494 117 µM 14.1574172231023 1.67882108759241e-45 yes 3 8.40290431012064e-46 6 712797 YDL207W GLE1
SGTC_2582 agaric acid 100 µM 13.9265389339944 4.24989322991067e-44 yes 4 2.18512873561191e-44 22 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_86 0417-1630 471.922 µM 13.2080449166465 7.07549390633775e-40 yes 5 3.94228897043829e-40 24 3634867
SGTC_64 000l-0018 272.079 µM 12.9673275057433 1.63933011702638e-38 yes 6 9.37263956922702e-39 26 6811119
SGTC_103 0844-0104 51.839 µM 12.4229139834692 1.6225984118574e-35 yes 7 9.81398402205177e-36 14 5375804
SGTC_58 0957-0393 9 µM 11.4863233638797 1.16756908372811e-30 yes 8 7.72752904246397e-31 56 6997992
SGTC_794 k038-0031 316 µM 9.299503010059 8.92825855980627e-21 yes 9 7.05518431023927e-21 21 6624242
SGTC_107 0358-0022 2.6945 µM 9.29113623534583 9.65314959655629e-21 yes 10 7.63249612994534e-21 7 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_67 0335-0847 266 µM 9.08365972420941 6.54399624554872e-20 yes 11 5.24920588304006e-20 29 4552207 YOR254C SEC63
SGTC_3059 1327-0034 3 µM 8.98059892618809 1.66690826461168e-19 yes 12 1.34648400170591e-19 14 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_138 0850-0259 40.9225 µM 6.86990911634671 3.52414782844298e-12 yes 13 3.21214097284541e-12 78 6813004
SGTC_158 k038-0087 26.446 µM 6.76845430400913 7.10678485880983e-12 yes 14 6.50827429217418e-12 57 X158
SGTC_36 0335-0881 14.2 µM 6.37291309440412 9.95088506481528e-11 yes 15 9.27354976714445e-11 55 23828853
SGTC_3063 1327-0034 4 µM 6.33262292432588 1.29097148672331e-10 yes 16 1.20514059050433e-10 18 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2808 7946468 45.46 µM 5.9184633368238 1.71198762269134e-09 yes 17 1.62481711737587e-09 6 2970879
SGTC_500 h-89 112 µM 5.79419958575315 3.59978230105366e-09 yes 18 3.43238913667198e-09 11 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_352 k048-0007 5.11 µM 5.55391818629305 1.45230958326131e-08 yes 19 1.39668130163764e-08 38 6811911
SGTC_580 1123-0028 41 µM 5.24784976157036 7.92021090352689e-08 yes 20 7.69423537040834e-08 7 1677248 YPR107C YTH1
SGTC_1950 st077106 7.18 µM 5.00723230400446 2.82125973073885e-07 yes 21 2.76091344934054e-07 11 13831864
SGTC_1942 st076330 65.2 µM 4.71500608825852 1.22489601709337e-06 yes 22 1.20851760986162e-06 15 24208414
SGTC_852 0418-0143 439 µM 4.69894293551142 1.32471470726806e-06 yes 23 1.30755752262862e-06 46 5369229
SGTC_16 erodoxin 22.806 µM 4.38849894430964 5.73707056808887e-06 yes 24 5.70678443464018e-06 51 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3060 1327-0027 12.5 µM 4.38173242100582 5.91727075994298e-06 yes 25 5.88696769327951e-06 30 16000455 YPR107C YTH1
SGTC_1383 3049-0032 20.7 µM 4.36744022177349 6.31580525124999e-06 yes 26 6.28555936877853e-06 16 712864
SGTC_2665 lovastatin 100 µM 4.32878849177265 7.52593909398887e-06 yes 27 7.49659191389904e-06 7 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2694 st077685 81.9 µM 4.22873794802466 1.17698085521316e-05 yes 28 1.17502939969777e-05 22 2838096
SGTC_590 k048-0076 22.4 µM 4.22464298279963 1.19847874054694e-05 yes 29 1.19659934220966e-05 9 6832814
SGTC_71 0417-1750 47.813 µM 4.12462981104753 1.85557998627943e-05 yes 30 1.85665758057264e-05 42 6811472
SGTC_1969 st069479 40.1 µM 4.11893080529444 1.90183979285318e-05 yes 31 1.9031720690966e-05 9 3895485
SGTC_2406 ethylparaben 405.7 µM 4.08956893096768 2.15804433088479e-05 yes 32 2.16087811197137e-05 30 8434 A possible steroid mimic.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.96712928629931 3.62346089096165e-05 yes 33 3.63717681331683e-05 40 688788
SGTC_871 0574-0004 149 µM 3.90638384869778 4.6612513607166e-05 yes 34 4.6843822820236e-05 49 9551173
SGTC_93 0109-0045 59.227 µM 3.83379122271311 6.26950220305885e-05 yes 35 6.30916253312738e-05 52 88733
SGTC_956 1185-0240 191 µM 3.77732008070519 7.86838229990819e-05 yes 36 7.92624730055454e-05 29 1416193
SGTC_1514 1189-1591 158 µM 3.77355067197941 7.98774271393565e-05 yes 37 8.04702561948472e-05 41 767698 YMR146C TIF34
SGTC_1949 st076024 69.1 µM 3.7470681911599 8.87561590165006e-05 yes 38 8.94567303614046e-05 33 2921930
SGTC_759 3486-0358 89.3 µM 3.71246951615909 0.000101758472845407 yes 39 0.000102623393827586 24 875103
SGTC_1161 k007-0610 110 µM 3.69792403751826 0.000107742047639765 yes 40 0.000108684956119823 131 5843850
SGTC_2466 5983409 37.09 µM 3.68627057450065 0.000112772672132421 yes 41 0.000113782201904777 26 2879657
SGTC_1961 st076550 68.7 µM 3.66819346496474 0.000121014530999027 yes 42 0.000122135162546648 18 1579337
SGTC_399 oxolinic acid 75 µM 3.66526100493546 0.000122403645373157 yes 43 0.000123543230569531 12 4628 A DNA gyrase inhibitor.
SGTC_340 k038-0059 454 µM 3.63970677140898 0.000135157855628302 yes 44 0.000136474342842263 54 23733424
SGTC_572 0960-0087 17.7 µM 3.62297937914663 0.000144170101591578 yes 45 0.000145614523805563 37 6796365
SGTC_7 0192-1582 4.227 µM 3.576201640458 0.000172451604373724 yes 46 0.000174311393538858 80 252616
SGTC_2064 5220758 200 µM 3.53925345104582 0.000198373653017401 yes 47 0.000200630198703632 51 788518
SGTC_2111 5486399 200 µM 3.53087606248731 0.000204736879084671 yes 48 0.00020709288576286 68 689674
SGTC_1093 fluphenazine 7.97 µM 3.45366012494033 0.000273050048209291 yes 49 0.000276516938910886 26 6602611 An atypical antipsychotic.
SGTC_367 0335-0881 7.1 µM 3.40545638877674 0.000325896777303239 yes 50 0.000330267813796858 107 23828853
SGTC_1979 st071809 45.3 µM 3.38241045377347 0.000354391665650019 yes 51 0.000359263494316066 30 4976333
SGTC_543 3844-1095 191 µM 3.37778162274248 0.000360387160543125 yes 52 0.000365365428485841 68 4230703
SGTC_9 0092-0002 10.449 µM 3.31646748860104 0.000449222115084465 yes 53 0.000455815968052134 57 759368
SGTC_598 3937-0236 20.2 µM 3.18476239195479 0.000712661221055682 yes 54 0.000724364531916821 62 1379313
SGTC_1827 berberine 7.24 µM 3.17246459527271 0.000743431179753157 yes 55 0.000755754939483086 54 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3318 9139014 38.6185 µM 3.16062227524802 0.000774214029624778 yes 56 0.000787162554732797 38 16643984
SGTC_1076 itraconazole 331 nM 3.15701492061455 0.000783821630542727 yes 57 0.000796965950785987 62 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1562 morin hydrate 59.1 µM 3.12436363692159 0.000875911344361347 yes 58 0.000890950465997904 53 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1407 3909-7909 12.3 µM 3.09888525032318 0.000954569787036409 yes 59 0.000971251197533696 49 4411780
SGTC_2350 9023895 38.85 µM 3.09840637071261 0.000956108451953981 yes 60 0.000972822190450239 66 2997209
SGTC_236 1509-0011 5.31 µM 3.09561951332519 0.000965108054957706 yes 61 0.000982011028767116 453 3107280
SGTC_225 nsc-122657 1.016 µM 3.09429837860551 0.000969401517103642 yes 62 0.00098639485948161 23 275685
SGTC_2884 9058502 51.95 µM 3.04155585415743 0.00115582566359319 no 63 0.00117679447334781 69 6471554
SGTC_1987 st072290 61.9 µM 3.04136888787906 0.00115654128443166 no 64 0.00117752553540642 47 54697379
SGTC_2651 TUB2.036 5 µM 3.02418167170131 0.00122408604819504 no 65 0.00124653340538698 237 15992207 YFL037W TUB2
SGTC_2511 berberine 10.47 µM 3.01578022722659 0.00125840004930376 no 66 0.00128159484051714 55 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3136 9095672 49.47 µM 3.01031009706822 0.00128121227627573 no 67 0.00130490545127345 66 17217380
SGTC_29 0299-0004 12.984 µM 2.99877658833397 0.00133055487760369 no 68 0.00135532996746842 59 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2233 sulbentine 40.3845 µM 2.98827802471763 0.00137697346349557 no 69 0.00140277106497205 117 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_125 0133-0007 11.75 µM 2.97908619000551 0.00141882397325953 no 70 0.00144554721328396 46 26541
SGTC_180 1486-1293 102.781 µM 2.97622838105392 0.00143207034113429 no 71 0.00145908728004375 89 4140536
SGTC_553 k007-0256 45.7 µM 2.91170274110647 0.00176287040505278 no 72 0.00179732271976138 82 6287000
SGTC_2748 diazoxide 86.69 µM 2.90675378190745 0.00179091195019059 no 73 0.00182600263657725 35 3019 A potassium channel activatior.
SGTC_2552 juarezic acid 87.02 µM 2.89573946012631 0.00185478259508264 no 74 0.00189133154669449 92 1549512
SGTC_1719 st032227 49.2 µM 2.89462986107761 0.00186133050173847 no 75 0.00189802927726148 82 3125804
SGTC_1740 st038286 13.222 µM 2.88194233447339 0.00193770955230313 no 76 0.00197616028881603 90 716786
SGTC_23 0213-0011 39.996 µM 2.87780331224031 0.00196323569012867 no 77 0.00200227366804397 72 627608
SGTC_268 camptothecin 39.6153 µM 2.86260157583052 0.0020596297269062 no 78 0.00210089277863576 164 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1802 st050112 57.9 µM 2.83678778629669 0.00223319692666758 no 79 0.00227849447389885 49 4662563
SGTC_1063 disulfiram 1.84 µM 2.82145093678046 0.00234249229877933 no 80 0.00239034748458763 85 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1812 st052057 4.327 µM 2.817064120682 0.00237463277155888 no 81 0.00242324244648124 88 3645418
SGTC_2730 imipramine 71.33 µM 2.81635730588834 0.00237984849997991 no 82 0.00242858071130429 91 3696 A tricyclic antidepressant.
SGTC_249 wiskostatin 11.211 µM 2.79011782732183 0.00258096586154782 no 83 0.00263444314361115 65 2775510 A n-wasp and actin depolymerizer.
SGTC_1125 tnp00248 1.32998 µM 2.77410012801535 0.00271116313744351 no 84 0.00276773190771072 131 24207736
SGTC_3043 9092303 49.47 µM 2.7672559284076 0.00276858112937847 no 85 0.00282651786061235 74 25236084
SGTC_1709 st033179 39.1045 µM 2.75492350214983 0.00287481813453902 no 86 0.00293529297561267 76 573381
SGTC_2247 cerulenin 830 nM 2.75392606595585 0.00288356913103408 no 87 0.00294425343928799 81 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2526 patulin 37.61 µM 2.75366296555581 0.00288588143981593 no 88 0.00294662110627541 194 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_89 0302-0250 142.109 µM 2.74139060950056 0.00299561499885875 no 89 0.00305898642933355 88 4203518 YLR208W SEC13
SGTC_2804 7954240 19.48 µM 2.73114478078564 0.00309009251215717 no 90 0.00315573691376509 114 828705
SGTC_578 3460-0051 92 µM 2.72730224563978 0.00312621096435685 no 91 0.00319272598746139 74 2876744
SGTC_1633 st005664 67.9 µM 2.72079904986598 0.00318820536911156 no 92 0.00325621683786202 119 2063822
SGTC_3128 9127691 49.47 µM 2.70591498362549 0.00333427660606497 no 93 0.00340582409629871 72 41316314
SGTC_1974 st069448 26.9 µM 2.69372983611277 0.00345830992779199 no 94 0.00353287056609903 78 6323587 YNR016C ACC1
SGTC_3029 9088683 49.47 µM 2.69075498370448 0.00348921376342472 no 95 0.00356452660332304 90 25236615
SGTC_489 paxilline 115 µM 2.67944433009264 0.0036089897579615 no 96 0.00368722322786602 79 105008 A toxic potassium channel blocker.
SGTC_906 1165-0455 526 µM 2.6758232541164 0.00364810820853171 no 97 0.00372729731690828 58 3252859
SGTC_1046 2001-0062 216 µM 2.66308608269128 0.00378874841374133 no 98 0.00387138019043388 81 739778
SGTC_2241 6772625 37.8075 µM 2.65317168483329 0.00390156418031618 no 99 0.00398696505711331 88 2285411
SGTC_528 3492-0019 172 µM 2.60648485881728 0.00447429133745893 no 100 0.00457384341258747 358 2869262
SGTC_690 glyoxal 20.3 µM 2.6047183222291 0.00449736572970186 no 101 0.004597490940326 184 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1428 4049-0204 61.7 µM 2.58509465864431 0.00476092668033095 no 102 0.0048676133040899 88 X1428
SGTC_2051 5263410 176 µM 2.58192722258127 0.00480473525862248 no 103 0.00491251507231817 85 227584
SGTC_971 1315-0384 26.7 µM 2.58101883810395 0.00481736519920098 no 104 0.00492546030879039 116 6769120
SGTC_1401 3807-4679 7.6 µM 2.5718951711312 0.00494586923283492 no 105 0.00505717560628911 82 3291456
SGTC_1252 0493-0875 34.8 µM 2.5677959175044 0.00500459378140354 no 106 0.00511736959690163 117 3960963
SGTC_3160 9100216 49.47 µM 2.56686440915992 0.00501802454545649 no 107 0.00513113660115828 51 17191039
SGTC_691 1548-0686 185 µM 2.54082471701532 0.00540669908189137 no 108 0.00552956735608671 155 46495133
SGTC_2109 5483026 200 µM 2.53890589262594 0.00543637146540789 no 109 0.00555998650778151 129 759335
SGTC_1423 4048-0112 5.59 µM 2.53623665525803 0.00547788880302356 no 110 0.0056025491607113 107 X1423
SGTC_3144 9087057 49.47 µM 2.530738375569 0.0055642980612332 no 111 0.00569113564826038 97 17249618
SGTC_2442 5158906 48.48 µM 2.52401354285763 0.00567162798871893 no 112 0.00580117294038159 110 1893835
SGTC_1276 0871-0068 94.2 µM 2.52084462381155 0.00572283885186646 no 113 0.00585367672653419 97 3414906
SGTC_2223 6903751 107.57 µM 2.51268810709328 0.00585654359381672 no 114 0.00599076050601183 71 5598863
SGTC_1461 k072-0203 53.8 µM 2.51026482817161 0.00589679727689194 no 115 0.0060320324344514 98 5418714
SGTC_136 0097-0015 404.482 µM 2.50787137444728 0.00593679620639065 no 116 0.00607304358675094 128 4861337
SGTC_2506 ethyl hematommate 54.16 µM 2.48099529941326 0.00640273702624243 no 117 0.00655080504032388 102 3940691 An allergen.
SGTC_2536 dehydroabietamide 32.04 µM 2.47922335295242 0.0064345640068314 no 118 0.0065834413323825 151 3983547
SGTC_3131 9127911 49.47 µM 2.47808706116098 0.00645504720676223 no 119 0.00660444550997125 125 45595681
SGTC_533 1222-0222 6.71 µM 2.46045535786164 0.00678035703280067 no 120 0.0069380416909572 134 3982874
SGTC_173 1273-0061 2.693 µM 2.45631666097556 0.00685878462566243 no 121 0.00701847033936957 283 2847414 YPL266W DIM1
SGTC_575 k072-0246 11.9 µM 2.45204558674599 0.00694055974856239 no 122 0.00710233324929518 130 6796779
SGTC_705 1124-0212 310 µM 2.44829970106963 0.00701298677710916 no 123 0.00717661050297131 105 9554485
SGTC_1178 0988-0033 191 µM 2.4473595129218 0.00703126980071701 no 124 0.00719536074706596 167 5392207
SGTC_2027 5150920 200 µM 2.44089399042594 0.0071581424888875 no 125 0.00732547740905881 88 786715
SGTC_2781 5567276 71.43 µM 2.43398469903015 0.0072959512627592 no 126 0.00746681317515214 169 2853274
SGTC_3347 9188721 44.724 µM 2.43053707660443 0.00736558630064337 no 127 0.00753823171580838 107 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_220 paclitaxel 373.376 µM 2.4261460992263 0.00745512292468594 no 128 0.00763006282181328 74 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1014 4130-3005 69.3 µM 2.42307027362582 0.00751841204014786 no 129 0.00769497463271365 143 743608
SGTC_1032 k061-1018 98.7 µM 2.42230496997893 0.00753423249634505 no 130 0.00771120082279171 154 4005393
SGTC_92 0063-0024 660.874 µM 2.4183254327377 0.00761697155313508 no 131 0.0077960625044018 106 3594437
SGTC_1647 st011722 22.4 µM 2.40848950169981 0.00782491296634195 no 132 0.00800934349592178 100 2854783
SGTC_3033 9090887 49.47 µM 2.40335298158619 0.00793547652837278 no 133 0.0081227489321694 154 19325384
SGTC_343 4130-2827 29.8 µM 2.37689689129254 0.00852697722731982 no 134 0.00872948383260218 142 1118244
SGTC_43 0570-0105 72.5 µM 2.35689853742467 0.00899943226375883 no 135 0.00921414062802054 306 1114046 YDL195W SEC31
SGTC_2892 9047358 58.44 µM 2.35300046534462 0.00909414761751866 no 136 0.00931130539238868 85 6466771
SGTC_2524 avocatin b 10.57 µM 2.35235046837908 0.00911002586429752 no 137 0.00932759436439665 107 6710748
SGTC_2311 7694451 200 µM 2.351921639722 0.00912051465554683 no 138 0.00933835448681196 144 2163142
SGTC_187 1488-2104 32.728 µM 2.34874289805268 0.00919859423236459 no 139 0.00941845427265123 150 2852859
SGTC_2301 7769476 200 µM 2.34765398926547 0.00922547536518137 no 140 0.00944603107943535 112 977820
SGTC_2819 7996655 46.38 µM 2.33731300988713 0.00948420177562916 no 141 0.00971145728271312 123 6456960
SGTC_1838 st055369 84.5 µM 2.33292626297935 0.0095958587627788 no 142 0.0098260078529512 130 676036
SGTC_22 0964-0034 14.468 µM 2.33161616818286 0.00962942698829005 no 143 0.0098604462470695 184 138402
SGTC_1750 st081859 2.357 µM 2.33133500384571 0.00963664455220906 no 144 0.00986785092242429 371 5291695
SGTC_1993 st073995 70.8 µM 2.32720245532888 0.00974327489339401 no 145 0.00997724620613021 133 3098394
SGTC_1385 3091-4834 14.1 µM 2.312599332137 0.0101283730472331 no 146 0.0103723391449252 128 4072814
SGTC_2800 7887935 81.82 µM 2.31022709925528 0.0101921690762386 no 147 0.0104377922473695 161 2961002
SGTC_2143 5623677 140.463 µM 2.30092741196211 0.0104456562977873 no 148 0.0106978671903401 88 5375313
SGTC_330 1488-0319 80.1 µM 2.29742581708576 0.0105425156664643 no 149 0.0107972452067972 127 6846614
SGTC_1944 st076371 56.9 µM 2.29437406016457 0.010627569090932 no 150 0.0108845109169228 172 24208455
SGTC_2811 7967822 32.47 µM 2.27667225380157 0.0111328074682249 no 151 0.0114029023025727 140 2232244
SGTC_55 0767-0285 6.563 µM 2.27653618095494 0.0111367707407615 no 152 0.0114069688261153 187 3116166
SGTC_3012 9080433 71.4286 µM 2.26475480309074 0.0114846012532922 no 153 0.0117638651901247 137 17688859
SGTC_3332 9141069 11.198 µM 2.26454015708827 0.0114910249641023 no 154 0.0117704564040663 124 17332883
SGTC_1998 st075797 76.8 µM 2.25453993094306 0.0117937817791855 no 155 0.0120811107774992 174 24208315
SGTC_3181 9108277 49.47 µM 2.24931794088184 0.0119546110289505 no 156 0.0122461375919189 147 17097298
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.23192639185566 0.012504036977055 no 157 0.0128099141312986 176 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2429 5902844 64.44 µM 2.22398924207713 0.0127619646712253 no 158 0.0130745840273406 194 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2682 pyrogallin 40.03 µM 2.22308649664693 0.0127915900424968 no 159 0.0131049840049092 194 822798 An ATP competetive kinase inhibitor.
SGTC_1018 4259-0013 28.1 µM 2.21795291264663 0.0129611923057401 no 160 0.0132790215815119 147 6801262
SGTC_2891 9063876 19.48 µM 2.21636037482758 0.013014199848709 no 161 0.0133334156016856 79 6472478
SGTC_846 0335-0850 148 µM 2.21505144142929 0.0130579078527159 no 162 0.0133782669340418 154 6819598
SGTC_922 1866-0035 480 µM 2.20766766031475 0.0133068518200268 no 163 0.0136337243955806 258 3156169
SGTC_1627 st003713 25.6 µM 2.2014965115684 0.0135180463598459 no 164 0.013850446690573 286 16195070 YER133W GLC7
SGTC_1822 st052468 42 µM 2.19233913271106 0.0138367684072551 no 165 0.0141775140506213 133 2873678
SGTC_2128 5255449 168.493 µM 2.1884670213603 0.0139734742796038 no 166 0.0143178004756067 205 736008
SGTC_250 brefeldin a 552.239 µM 2.17311506616951 0.0145269990455051 no 167 0.0148858290244369 121 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1597 7-benzyloxygramine 47.5 µM 2.17272713504247 0.0145412272029559 no 168 0.0149004301154325 374 260807
SGTC_1884 5633444 25 µM 2.16746270696925 0.0147354996367043 no 169 0.0150997951637015 223 5724239
SGTC_273 hydroxyurea 18.1 mM 2.16694679572926 0.0147546578054338 no 170 0.0151194555944785 216 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2289 7946404 165.07 µM 2.16206667615092 0.0149369414760252 no 171 0.0153065185874422 272 1246120 YPR165W RHO1
SGTC_3064 1327-0027 10 µM 2.15873490875894 0.0150624998260422 no 172 0.015435369441004 79 16000455 YPR107C YTH1
SGTC_945 3381-0768 11.3 µM 2.14574334447103 0.0155607908079121 no 173 0.0159467304955274 190 1126236 YIL048W NEO1
SGTC_1446 4239-0190 62 µM 2.13741524451952 0.0158876017734401 no 174 0.0162821162937504 220 1340085
SGTC_1575 cyproterone acetate 48 µM 2.11938303842965 0.0166154370807194 no 175 0.0170290545341516 190 9880 An androgen receptor antagonist and liver toxin.
SGTC_95 0471-0001 561.058 µM 2.10260154558549 0.0173182380814183 no 176 0.0177503073598188 201 4015405
SGTC_294 k038-0071 157 µM 2.09778749756226 0.017524475941893 no 177 0.017961960719411 250 24152826
SGTC_2396 5342950 42.78 µM 2.09013370039532 0.017856686890696 no 178 0.0183028955677996 250 1886677
SGTC_2533 agelasine 13.65 µM 2.08304614844342 0.0181690956259999 no 179 0.0186235086383339 241 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1936 st074407 74.3 µM 2.07904632442141 0.0183474494368283 no 180 0.0188065464243798 252 809813
SGTC_1983 st071813 46.9 µM 2.0786416694483 0.018365575965926 no 181 0.0188251490008944 181 11838595
SGTC_168 3970-0862 530.542 µM 2.07488030490416 0.018534797504731 no 182 0.0189988147382664 426 3135186
SGTC_1817 st052116 64.4 µM 2.06313974472291 0.0190715623622558 no 183 0.019549676491381 182 4361398
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.06259904831251 0.0190965975132041 no 184 0.0195753691267797 219 5393153
SGTC_684 1140-0066 328 µM 2.06122963217336 0.0191601288111054 no 185 0.0196405689071118 240 6813534
SGTC_2148 5546263 113.568 µM 2.0557324039688 0.019416973019973 no 186 0.0199041583556649 198 792097
SGTC_1392 3455-1037 33.9 µM 2.05409243813915 0.0194941605104367 no 187 0.0199833729048558 187 981132
SGTC_414 piperonyl butoxide 100 µM 2.05386165581769 0.0195050435233202 no 188 0.0199945417202397 160 5794 A potent inhibitor of cytochrome P450.
SGTC_2146 5545642 200 µM 2.0311668215414 0.0206007671507661 no 189 0.0211190374108788 168 825326
SGTC_258 haloperidol 50.781 µM 2.01366737057971 0.0214808605096417 no 190 0.0220222339903991 261 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2032 5185112 25.99 µM 2.01348111098946 0.021490396321454 no 191 0.0220320200825247 181 5718189
SGTC_2461 5755302 26.15 µM 2.00881467834648 0.0217304709997183 no 192 0.0222783955032012 247 2788904
SGTC_3297 9117502 71.43 µM 2.00646428576457 0.0218522474904237 no 193 0.022403367747714 170 7453720
SGTC_1666 st014829 29 µM 2.00374427715033 0.021993893120969 no 194 0.0225487303221117 238 3858230
SGTC_1145 3546-0597 10.2 µM 2.00310149060247 0.0220274795111182 no 195 0.0225831980202325 235 875334
SGTC_3208 9114115 49.47 µM 1.99596463339681 0.0224033070523504 no 196 0.0229688862652684 243 650895
SGTC_1563 conessine 56.1 µM 1.99595443820483 0.0224038477764928 no 197 0.0229694411751617 256 441082 An anti-amoebic, histamine inhibitor.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.98589230931495 0.022942908065034 no 198 0.0235226414353511 192 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_272 doxorubicin 8.13 µM 1.97528242595062 0.0235231059152681 no 199 0.024118053227356 264 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_883 0850-0245 24.6 µM 1.96767393323728 0.023946731484829 no 200 0.0245527834618108 263 6823229 YPR165W RHO1
SGTC_2996 9066192 71.4286 µM 1.96645131055506 0.0240153989943075 no 201 0.0246232506746932 264 6472854
SGTC_1761 st044296 37 µM 1.96441782573681 0.024129974262904 no 202 0.0247408286459562 204 1826700
SGTC_1195 1502-0147 41.1 µM 1.96299610758205 0.0242103524335531 no 203 0.0248233131601682 252 817940
SGTC_2307 7538926 6.34 µM 1.95200724900429 0.0248392354594376 no 204 0.0254686719893846 287 96582
SGTC_1783 st039459 87.517 µM 1.94439202084637 0.0252830389891905 no 205 0.025924097668146 271 729761
SGTC_3284 9108171 64.8615 µM 1.9426801243518 0.0253837150184012 no 206 0.026027409578615 195 8687505
SGTC_150 3970-0969 77.2 µM 1.94083374170259 0.0254926763240504 no 207 0.026139223441031 329 6615640
SGTC_386 1509-0011 3.07 µM 1.93690202024803 0.0257260060314305 no 208 0.0263786607326509 373 3107280
SGTC_617 3770-0098 35 µM 1.93552620644493 0.0258080753481124 no 209 0.0264628779876569 214 5962639
SGTC_1295 1013-0063 9.78 µM 1.92855856525362 0.0262270770954603 no 210 0.0268928435542599 234 6826038
SGTC_2236 dapsone 200 µM 1.91011195773458 0.0273639076352173 no 211 0.0280593998529083 235 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2711 st079103 59.1 µM 1.90401170823859 0.0277487811694476 no 212 0.0284543296768766 194 54693780
SGTC_2147 5545932 89.7195 µM 1.90219892582542 0.0278640178557669 no 213 0.0285725766099023 214 797404
SGTC_2767 sibutramine 71.45 µM 1.89759169976654 0.0281586896778739 no 214 0.0288749443343637 237 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_200 k038-0079 37.545 µM 1.88362081322386 0.0290681502506664 no 215 0.0298081422489626 250 3436683
SGTC_3251 9135047 49.47 µM 1.88284620378461 0.0291192808767136 no 216 0.0298606067232158 181 17682963
SGTC_1397 3532-0190 20.1 µM 1.87879565597943 0.0293878689182397 no 217 0.0301362002160145 185 5322280
SGTC_216 k038-0035 28.382 µM 1.87311056222921 0.0297683089938581 no 218 0.0305265595649492 220 4444231 YPR107C YTH1
SGTC_1280 0880-0253 10.1 µM 1.86916576799275 0.0300346843226454 no 219 0.0307998776178263 263 6836607
SGTC_2701 st077767 14.721 µM 1.86855603285667 0.0300760329922748 no 220 0.030842303798167 313 5721188
SGTC_2939 9044578 71.43 µM 1.86807383343234 0.0301087663478653 no 221 0.0308758901207507 277 2653634
SGTC_3322 9139058 2.11 µM 1.86378035615684 0.0304015266169557 no 222 0.031176277723145 263 4908926 YPR165W RHO1
SGTC_1097 itavastatin 7.23 µM 1.85773016684466 0.0308180721884539 no 223 0.0316036711625067 284 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2583 asiatic acid 100 µM 1.84130781473069 0.0319725941536579 no 224 0.0327882315922748 263 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_776 4476-4378 112 µM 1.83978742187905 0.0320812637527493 no 225 0.0328997263935644 231 2892008
SGTC_2336 9001819 198.65 µM 1.83977338836824 0.0320822682120911 no 226 0.0329007569651608 330 2989602
SGTC_507 nimesulide 162 µM 1.83762502003762 0.0322363458673012 no 227 0.0330588396882535 279 4495 A COX2 inhibitor.
SGTC_2788 5282734 71.43 µM 1.83757761474282 0.0322397525767135 no 228 0.0330623349424113 321 743706
SGTC_3262 9137218 49.47 µM 1.83070727218478 0.0327366307137809 no 229 0.0335721235330884 127 17650664
SGTC_711 k292-0785 179 µM 1.81801962195677 0.0336708229237589 no 230 0.034530566890951 284 4146315
SGTC_2175 5807670 165.306 µM 1.81557758768988 0.0338531241063795 no 231 0.0347175970982417 257 241186
SGTC_2115 tiliquinol 12.7705 µM 1.8145125640494 0.0339328834509153 no 232 0.0347994251026369 228 71208 A bioactive hydroxyquinoline.
SGTC_2391 6285546 200 µM 1.80508286797075 0.034645834511071 no 233 0.0355308577608521 315 846083
SGTC_2399 5884133 200 µM 1.80222791722887 0.0348640993193797 no 234 0.0357547770594972 334 722445
SGTC_2470 5664817 21.68 µM 1.80026534316314 0.0350147944684744 no 235 0.0359093752304201 241 2859561
SGTC_1614 st002383 48.6 µM 1.79461122484685 0.0354519335439478 no 236 0.0363578317408313 283 1947235
SGTC_2646 retinol 96.75 µM 1.79308018271493 0.0355710704932276 no 237 0.036480051947867 261 445354 A vitamin A analog and teratogen.
SGTC_338 4055-0136 114 µM 1.78619784278657 0.0361106750761935 no 238 0.0370336151296791 296 2900563
SGTC_1937 st074714 47.2 µM 1.78232111842599 0.0364175662703701 no 239 0.0373484403806883 302 17250970
SGTC_1771 st048882 4.1505 µM 1.78059837494001 0.0365546263051938 no 240 0.037489042727425 283 4580403
SGTC_2829 7992743 58.44 µM 1.77567746780815 0.0369484555273371 no 241 0.0378930466483331 326 16462845
SGTC_1478 0453-0656 35.7 µM 1.77352229922745 0.0371220265093778 no 242 0.0380711000895207 292 5258496
SGTC_503 tyrphostin 8 294 µM 1.77103125332399 0.0373234776940317 no 243 0.0382777523495293 316 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1909 st060837 51.5 µM 1.76757102782184 0.0376047875087871 no 244 0.038566322527212 316 678937
SGTC_1608 st001473 40.5 µM 1.76583540621378 0.0377465408406727 no 245 0.0387117332789498 311 7292267
SGTC_673 1082-0474 110 µM 1.76386031975048 0.0379083822204213 no 246 0.0388777494626941 393 3098046
SGTC_2390 9097792 176.6 µM 1.76349766237576 0.0379381603175112 no 247 0.0389082955989206 265 4497149
SGTC_2370 9071495 200 µM 1.76183371477984 0.0380750331997588 no 248 0.0390486982920263 310 21791103
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.75284188475502 0.0388216680320131 no 249 0.0398145756880592 322 688801
SGTC_2086 5274770 176.623 µM 1.75166685620848 0.038920111385131 no 250 0.0399155545914472 306 689278
SGTC_176 1486-1328 72.834 µM 1.74965743409137 0.0390889308539418 no 251 0.0400887213922965 362 22310231
SGTC_2207 7258803 200 µM 1.7410122022064 0.0398220627610515 no 252 0.0408407198296794 246 3666799
SGTC_351 caspofungin 25 nM 1.73436621745927 0.0403932215650764 no 253 0.041426562599348 457 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2368 9071271 200 µM 1.73390788372363 0.0404328549096548 no 254 0.0414672144120709 329 27209959
SGTC_2400 5203494 178.7 µM 1.72932392894563 0.0408309812755546 no 255 0.0418755681429169 287 6777674
SGTC_1044 1222-0021 1.78 µM 1.72149495411731 0.0415182950067443 no 256 0.0425805235138171 343 4306703
SGTC_2018 5133068 143 µM 1.71573702598542 0.0420297481955628 no 257 0.0431050923677462 321 785362
SGTC_1804 st050076 49.1 µM 1.70641879968125 0.0428682424344494 no 258 0.0439650664124662 311 3895976
SGTC_2472 5377652 49.4 µM 1.70034854378349 0.0434217055504301 no 259 0.0445326922475668 384 1610903
SGTC_1192 1488-0095 21.4 µM 1.69081363898945 0.0443026956162386 no 260 0.0454362007167806 314 915875
SGTC_1867 st057372 64 µM 1.67232049197179 0.0460524352873019 no 261 0.0472305704634379 325 688837
SGTC_1493 4348-0038 111 µM 1.67023340185682 0.046253345251349 no 262 0.0474365969139188 367 800424
SGTC_332 4112-0506 40.9 µM 1.66677843690627 0.046587477562999 no 263 0.0477792347247411 328 2790355
SGTC_2820 7989630 71.43 µM 1.66324975938162 0.0469307353332313 no 264 0.048131225459516 264 2984098
SGTC_1126 isoteolin 1.0172 µM 1.65894582727271 0.0473521496897422 no 265 0.0485633544846283 347 133323
SGTC_3124 9127567 49.47 µM 1.65488528454715 0.0477525076717496 no 266 0.0489738848944339 315 17592030
SGTC_3101 9120531 49.47 µM 1.65469939409306 0.0477709006286462 no 267 0.0489927450244293 367 24824904
SGTC_1350 1495-0454 146 µM 1.65097306276284 0.0481408010090433 no 268 0.0493720377010286 405 1069057
SGTC_361 000s-0510 1.45 µM 1.64977688831023 0.048260025975218 no 269 0.049494288733866 377 660
SGTC_2288 7946289 167.31 µM 1.64926977125181 0.0483106425367312 no 270 0.0495461898211159 408 1246052
SGTC_731 3966-0296 387 µM 1.64637224309487 0.0486006667470745 no 271 0.0498435720638356 336 660956
SGTC_265 mycophenolic acid 32.932 µM 1.64077457411228 0.0491648990799452 no 272 0.0504221090332526 373 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_120 rhodamine 6G 52.259 µM 1.63947243959896 0.0492968984523096 no 273 0.050557452961795 443 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2480 5767542 37.17 µM 1.63417317261661 0.049837014853533 no 274 0.051111246956599 332 2867358
SGTC_2246 7293507 91.5585 µM 1.62727407630989 0.0505472517250967 no 275 0.0518394505714009 370 887656
SGTC_3178 9107506 49.47 µM 1.62724282333184 0.0505504873554919 no 276 0.0518427680037837 354 8897194
SGTC_1342 1486-1464 234 µM 1.62570882991735 0.0507095050624151 no 277 0.0520058053854211 357 3253938
SGTC_706 4262-0057 46.9 µM 1.62493116602774 0.050790271735612 no 278 0.0520886132775645 364 883298
SGTC_2998 9066762 71.4286 µM 1.62359708765238 0.0509290650964711 no 279 0.0522309137163062 414 4945196
SGTC_1967 st070177 51.4 µM 1.62160409381656 0.0511369722261827 no 280 0.0524440727716612 322 5729214
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.61787429066038 0.0515278758326733 no 281 0.0528448459473253 350 688662
SGTC_999 SEC7.066 22.7 µM 1.61398540877851 0.0519379782619156 no 282 0.0532652956267486 409 740511 YDR170C SEC7
SGTC_1488 4013-0813 75.9 µM 1.60668809255034 0.0527145133029146 no 283 0.0540614035001463 305 2910057
SGTC_3089 9117425 49.47 µM 1.60545293574343 0.0528468579831192 no 284 0.0541970813777351 368 9401657
SGTC_3155 9099265 49.47 µM 1.60484798152571 0.0529117737566836 no 285 0.0542636318256549 334 25236499
SGTC_2479 5617353 43.85 µM 1.60316001164451 0.0530932390902957 no 286 0.0544496657554064 383 2731746
SGTC_192 3455-0609 60.9 µM 1.60190129818805 0.0532288780961178 no 287 0.054588718696575 353 3769639
SGTC_3023 9089636 49.47 µM 1.59751745383311 0.0537034267500027 no 288 0.05507520512087 355 17249241
SGTC_1669 st015249 58.4 µM 1.59582234075195 0.0538878176764184 no 289 0.0552642319586792 320 722793
SGTC_1334 1486-0610 236 µM 1.59528909367714 0.0539459267353707 no 290 0.0553238016752375 392 3742339
SGTC_2149 5554786 194.827 µM 1.59309553955957 0.0541854848762478 no 291 0.0555693799161565 419 745063 YPR165W RHO1
SGTC_20 0481-0013 4.944 µM 1.59029629266185 0.0544924124692111 no 292 0.0558840169552666 386 182045
SGTC_1017 4239-0030 168 µM 1.58863466958033 0.0546752529536126 no 293 0.0560714480996782 420 1149593
SGTC_3026 9090633 49.47 µM 1.582631053843 0.0553399196696385 no 294 0.0567527906186344 370 25236842
SGTC_1337 1486-1011 40.3 µM 1.57956493806758 0.0556818255473674 no 295 0.0571032670417173 337 X1337
SGTC_926 2268-1401 59.4 µM 1.57292993652209 0.0564274079538899 no 296 0.057867521181706 397 2931578
SGTC_3254 9136651 49.47 µM 1.57267257370573 0.0564564858490791 no 297 0.0578973267849143 415 16454030
SGTC_747 3448-8087 38.7 µM 1.57244864906981 0.0564817953691483 no 298 0.0579232696748223 422 5168703
SGTC_2340 7987427 183.45 µM 1.56444478214966 0.0573923336913417 no 299 0.0588565754523524 376 2239331
SGTC_2763 lisinopril 49.32 µM 1.56392780555193 0.0574515409199405 no 300 0.0589172618577962 335 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_6 0844-0013 19.835 µM 1.56095892494504 0.0577924855734221 no 301 0.0592667213392326 646 1584900
SGTC_2019 4016004 108 µM 1.56061138094495 0.0578325011317452 no 302 0.0593077359188184 338 45595336
SGTC_2025 5147754 141 µM 1.5599602327636 0.0579075317325011 no 303 0.0593846395296287 349 315777 YLR208W SEC13
SGTC_596 1155-0152 116 µM 1.55736796749155 0.0582069925702815 no 304 0.0596915734168614 454 280313
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.55699380650034 0.0582503162839273 no 305 0.0597359779463732 457 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2072 5231554 129 µM 1.556830026523 0.0582692881669672 no 306 0.0597554231032637 359 789545
SGTC_873 0591-4978 488 µM 1.55427307454772 0.058566109252531 no 307 0.060059646635258 407 3305145
SGTC_2183 6420625 130.508 µM 1.55334986412502 0.0586735703827329 no 308 0.0601697867869775 462 2897619
SGTC_2003 4023581 200 µM 1.55198727278469 0.0588324579120558 no 309 0.0603326344689126 396 16641307
SGTC_472 calcifediol 10 µM 1.550724330156 0.0589800270439738 no 310 0.0604838806496985 309 5283731 A vitamin D metabolite.
SGTC_2908 7930301 100 µM 1.54514653462304 0.0596352433409581 no 311 0.0611554116204947 435 2223178
SGTC_2179 6298986 200 µM 1.54449926660121 0.0597116449806273 no 312 0.0612337143964989 354 738374
SGTC_2267 7931562 200 µM 1.53701699592706 0.0606004078625063 no 313 0.0621445737087996 368 934880
SGTC_2434 5670830 169.91 µM 1.53202241314873 0.0611994134889186 no 314 0.0627584519921191 422 1549830
SGTC_523 1934-0222 13.7 µM 1.52989080171821 0.061456464383313 no 315 0.0630218802769511 418 1361595
SGTC_2328 6201408 200 µM 1.52880109587166 0.0615881972957298 no 316 0.0631568803191135 395 2890418
SGTC_1279 0874-0590 65.2 µM 1.5286716594261 0.0616038593146472 no 317 0.0631729307228525 401 3523074
SGTC_539 4859-0462 2.54 µM 1.5204575188969 0.0626041598175929 no 318 0.0641980138617753 390 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1871 st057448 67.3 µM 1.51884248279196 0.0628023166926985 no 319 0.0644010748031821 430 691747
SGTC_2101 5377231 179.231 µM 1.51689594649318 0.0630417961034075 no 320 0.0646464786017838 373 2844213
SGTC_3311 9131146 2.8755 µM 1.51650404617924 0.0630900969101069 no 321 0.0646959739921807 461 4900406 YPR165W RHO1
SGTC_2602 kawain 100 µM 1.50983683485882 0.0639162385712266 no 322 0.0655425317436283 468 5369129
SGTC_2741 miltefosine 3.04 µM 1.50933847584008 0.0639783271493636 no 323 0.0656061534542374 336 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1930 st074634 34.3 µM 1.50722008614416 0.064242772451627 no 324 0.0658771266783779 431 684253 YOR116C RPO31
SGTC_190 3970-0790 3.722 µM 1.50590796564393 0.0644069941930368 no 325 0.0660454007091006 374 2832352
SGTC_631 k072-0230 41.5 µM 1.50506433415779 0.0645127531726995 no 326 0.0661537687263911 447 5773147
SGTC_1889 st059080 5.18 µM 1.50294745644548 0.0647787222936461 no 327 0.0664262969933651 446 176925 Isolated from Daphnopsis sellowiana.
SGTC_2499 avocadenofuran 51.48 µM 1.50038516786279 0.0651017919200761 no 328 0.0667573296626667 456 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_381 3461-2219 42.7 µM 1.49916320532372 0.0652563044192715 no 329 0.0669156489378287 434 2883159
SGTC_663 1486-0733 13.9 µM 1.49861477355805 0.0653257439587154 no 330 0.0669867989326239 487 722445 YPR165W RHO1
SGTC_525 k781-2675 26.7 µM 1.49715922388621 0.0655103159342909 no 331 0.0671759162852433 458 3651118 YDL195W SEC31
SGTC_2176 5809774 33.9695 µM 1.49626242672803 0.0656242360976887 no 332 0.0672926411478707 422 2870539
SGTC_2658 polymyxin b sulfate 77.05 µM 1.48787601823831 0.0666970087232654 no 333 0.0683917966245801 444 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1741 st038134 10.228 µM 1.48736358380366 0.066762995697372 no 334 0.0684594047324198 479 1272587
SGTC_2268 7933382 153.85 µM 1.47863101807893 0.067895283103954 no 335 0.0696194789737232 511 935025 YOR257W CDC31
SGTC_1400 3771-8998 51.5 µM 1.47729819750261 0.0680693969202854 no 336 0.0697978604840704 391 670767
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.47689063054123 0.0681227084384034 no 337 0.0698524784438629 500 676296 Flavone; oxidizing agent.
SGTC_1992 st073643 23.3 µM 1.47505901633084 0.0683626894606713 no 338 0.0700983388035059 414 3161292
SGTC_872 0588-0139 234 µM 1.4734638881992 0.0685722166590359 no 339 0.0703129971164228 465 2047100
SGTC_2893 9048488 25.97 µM 1.47077349108134 0.0689267341468098 no 340 0.0706761918656896 416 6467338
SGTC_1050 3232-1156 69.3 µM 1.46689946884961 0.0694396994031836 no 341 0.0712017025232025 460 700529
SGTC_1260 0700-1617 7.75 µM 1.46106944336443 0.0702171970849043 no 342 0.0719981924582058 482 2853078
SGTC_2718 lomofungin 53.02 µM 1.46045546863225 0.0702994654762782 no 343 0.0720824688505714 422 5351222 A RNA synthesis inhibitor.
SGTC_2071 5230951 39.92 µM 1.45758306453164 0.0706853327320147 no 344 0.0724777502316788 464 1799272
SGTC_2378 9074213 121.43 µM 1.45403764125374 0.0711638525729585 no 345 0.0729679352922797 473 657714
SGTC_2749 bexarotene 57.39 µM 1.45324234077122 0.071271533724061 no 346 0.0730782400316205 458 82146 An retinoic acid receptor inhibitor.
SGTC_1395 3486-0190 4.35 µM 1.45176300797875 0.071472163339846 no 347 0.0732837564668804 468 6748079
SGTC_720 r052-1644 49.9 µM 1.44798343383763 0.0719867237211689 no 348 0.0738108418568058 399 1422863 YOR257W CDC31
SGTC_1170 0310-0127 64.8 µM 1.44523680928379 0.0723624344349945 no 349 0.0741956902181773 467 774975
SGTC_909 3448-9333 149 µM 1.44522239847575 0.0723644096437694 no 350 0.0741977134489914 404 3344074
SGTC_2921 7974240 10.71 µM 1.44472787119095 0.0724322167659641 no 351 0.0742671690166466 452 2979074 YDR527W RBA50
SGTC_1302 1159-0335 255 µM 1.44261803208958 0.0727220543691181 no 352 0.0745640504487317 433 649284
SGTC_2262 9014885 67.46 µM 1.44014542897232 0.0730628557315093 no 353 0.0749131293109919 348 6457424
SGTC_1024 4507-0395 26 µM 1.43986678055269 0.0731013386269836 no 354 0.0749525465603663 454 4201836
SGTC_3007 9078383 71.4286 µM 1.43902144035064 0.073218179713023 no 355 0.0750722241025527 445 6496995
SGTC_464 bw-b 70c 158 µM 1.43784881885362 0.0733804934039175 no 356 0.0752384771207848 492 5353454
SGTC_1525 8-methoxypsoralen 92.5 µM 1.43724004181787 0.0734648684793655 no 357 0.0753248994924836 511 4114 Related to psoralen; DNA damaging agent.
SGTC_2606 farnesol 9.78 µM 1.43365448803228 0.0739633239389529 no 358 0.07583544298187 469 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1309 pyrazolanthrone 13.4 µM 1.43326259842062 0.0740179598113936 no 359 0.0758914031398679 477 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_600 1495-0418 41.6 µM 1.42900816267502 0.0746130842814307 no 360 0.0765009436681608 444 5377768
SGTC_2447 5741742 33.78 µM 1.41598575432941 0.0764574046985785 no 361 0.0783898377060771 481 1776504
SGTC_2759 disulfiram 3.38 µM 1.41523576212607 0.0765646705340455 no 362 0.0784996911766253 470 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_746 1095-0025 46.6 µM 1.41334759834557 0.0768352274388015 no 363 0.0787767725495385 493 6749286
SGTC_1579 chlormadinone acetate 49.4 µM 1.41201918895866 0.0770260117253361 no 364 0.0789721555838596 482 45114258 A steroidal progestin.
SGTC_2083 5306046 65.942 µM 1.41038265672039 0.0772615429119903 no 365 0.0792133618270511 499 539837
SGTC_960 1222-0186 7.7 µM 1.40825287622106 0.0775688816888389 no 366 0.0795281020379269 497 3126296
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.40821085187428 0.0775749553535737 no 367 0.0795343219272372 516 5106787 A p450 inhibitor.
SGTC_3280 9140961 49.47 µM 1.40491766254223 0.0780520347862605 no 368 0.0800228818740892 447 4901226
SGTC_2161 5662504 8.5105 µM 1.40183693373256 0.0785003474275351 no 369 0.0804819733133076 453 2859334
SGTC_1196 1588-0294 184 µM 1.40125715377942 0.0785849357636181 no 370 0.0805685943810781 443 6144269
SGTC_2024 5144227 134 µM 1.39759592551302 0.0791206954945036 no 371 0.0811172212991567 527 3475211
SGTC_3216 9129716 49.47 µM 1.39667040372581 0.0792565671543383 no 372 0.0812563540659 451 8056934
SGTC_2966 9084041 48.03 µM 1.39433694465464 0.0795999157589963 no 373 0.0816079397522584 476 17741380
SGTC_2862 9027634 71.43 µM 1.39430450231136 0.0796046972927716 no 374 0.0816128359590825 467 5012562
SGTC_2981 9013952 38.96 µM 1.39114875468058 0.0800708484369957 no 375 0.0820901615505482 467 2996344
SGTC_1917 st066507 28.5 µM 1.38908343641653 0.0803770422220045 no 376 0.0824036899265419 535 3156428
SGTC_3165 9101544 49.47 µM 1.38885189512793 0.0804114244569901 no 377 0.0824388954888658 500 5002184
SGTC_1757 st041620 31.8375 µM 1.38850640867003 0.08046274739837 no 378 0.0824914473243326 478 5289815
SGTC_2082 5219693 150 µM 1.38096612796639 0.0815890496170313 no 379 0.0836446877989833 508 2834649
SGTC_3350 9150499 3.57 µM 1.37974169140787 0.0817730618961995 no 380 0.0838330956682684 562 4910996 YPR165W RHO1
SGTC_564 3555-0129 330 µM 1.37861413529979 0.0819427911847262 no 381 0.0840068779896785 395 563260
SGTC_2274 7947094 46.08 µM 1.37857359558087 0.0819488985064587 no 382 0.0840131311260143 509 2971028
SGTC_483 fpl-64176 144 µM 1.37457998122207 0.082552220464384 no 383 0.0846308492161355 409 3423
SGTC_1182 1222-0449 220 µM 1.37156687878639 0.0830096233078904 no 384 0.0850991552571865 483 658318
SGTC_784 4579-0127 173 µM 1.3667703787898 0.0837416827780781 no 385 0.0858486450522009 529 1948547
SGTC_857 0438-0306 1.35 µM 1.36670914641523 0.083751059538571 no 386 0.0858582449142009 490 4686136
SGTC_3255 9139072 49.47 µM 1.36479315780447 0.0840448611943335 no 387 0.0861590349628676 503 17646060
SGTC_2269 7935389 174.42 µM 1.36193771902156 0.084484155096672 no 388 0.0866087705827683 507 97605
SGTC_2801 7907800 81.82 µM 1.36189462762782 0.0844907976449589 no 389 0.0866155709521477 533 6620925
SGTC_2785 7756463 72.73 µM 1.3606867764173 0.0846771476366835 no 390 0.0868063476326121 492 2201551
SGTC_2102 5377816 72.7585 µM 1.35242251734278 0.0859604536629681 no 391 0.0881200950587143 527 1379702
SGTC_2165 5727197 32.143 µM 1.34911283779159 0.0864784550907931 no 392 0.0886503626854039 522 1361712
SGTC_589 1227-0070 34.1 µM 1.34891354012456 0.0865097217128603 no 393 0.0886823693035182 507 2841384
SGTC_546 peri-Naphthalide 147 µM 1.34636032832923 0.0869110278311554 no 394 0.0890931692749124 521 223824 A penicillin ester.
SGTC_610 4215-0184 155 µM 1.34606513226447 0.0869575154028298 no 395 0.0891407561444921 545 5605015
SGTC_73 0327-0325 16.231 µM 1.3433308150892 0.0873889997501132 no 396 0.0895824391401441 593 53298
SGTC_3190 9110366 49.47 µM 1.34199380434813 0.0876005653873314 no 397 0.0897990022701281 430 17123768
SGTC_3209 9113616 49.47 µM 1.34088875433644 0.0877757143571336 no 398 0.0899782869668579 559 16649353
SGTC_292 k038-0015 474 µM 1.33593342158665 0.088564341112592 no 399 0.0907855178719704 487 46368540
SGTC_1239 0337-0584 35.4 µM 1.33523233580348 0.0886763417381932 no 400 0.09090015834641 586 914301 YML130C ERO1
SGTC_2847 9005661 71.43 µM 1.3347161715406 0.088758867976736 no 401 0.0909846293565503 375 2991449
SGTC_1373 2887-0003 58.5 µM 1.33464456272004 0.0887703215742222 no 402 0.090996352839081 505 776948
SGTC_2036 5160441 105 µM 1.33183236183272 0.0892209947165289 no 403 0.0914576405794939 601 134534 YIL048W NEO1
SGTC_975 1335-0046 28.5 µM 1.33151727374454 0.0892715954635101 no 404 0.0915094325332653 516 16486740
SGTC_1701 st028638 40.4 µM 1.33067619567228 0.0894067707572605 no 405 0.0916477894527425 528 3490878
SGTC_1174 0739-0097 51.1 µM 1.33051481731008 0.0894327243550531 no 406 0.0916743538255619 547 728447
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.32948897368519 0.0895978362091022 no 407 0.0918433505919986 530 16623 A steroid.
SGTC_584 0986-0246 15.4 µM 1.32788376223135 0.0898566533101582 no 408 0.0921082548819079 585 53315 YDR232W HEM1
SGTC_2534 helenine 20.12 µM 1.32234898408039 0.0907533174684726 no 409 0.0930259842064309 463 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2676 harmalol 100 µM 1.32044289926623 0.091063645664593 no 410 0.0933435943109604 551 5459187 A monoamine oxidase inhibitor
SGTC_2033 5192550 145 µM 1.31137536046372 0.0925507079011755 no 411 0.0948654895494802 509 182073
SGTC_2832 7992762 51.95 µM 1.31038974744252 0.0927134231547633 no 412 0.0950320101060841 473 2985177
SGTC_1141 3253-0389 52.6 µM 1.30891500594279 0.0929572838031293 no 413 0.0952815714760392 521 5402031
SGTC_117 lucigenin 22.078 µM 1.3082415718702 0.0930687992430299 no 414 0.0953956929011912 600 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_980 1473-0395 201 µM 1.30773013193784 0.0931535557528954 no 415 0.0954824296906511 474 768876
SGTC_1931 st074438 57.1 µM 1.30618405081577 0.0934101212250738 no 416 0.0957449876402324 504 2787313
SGTC_1366 1683-0113 21.9 µM 1.30530421542581 0.0935563589467348 no 417 0.0958946396182829 516 708623
SGTC_1621 st003705 32.4 µM 1.30300969576876 0.0939385270735024 no 418 0.096285725717735 587 24207032
SGTC_2382 9035899 200 µM 1.30019998074536 0.0944080721978163 no 419 0.096766218621409 559 6462679
SGTC_2516 gossypol 71.55 µM 1.29945574419462 0.0945327346138166 no 420 0.0968937859350654 586 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_893 0958-0369 48.9 µM 1.29783144225364 0.0948052326747692 no 421 0.0971726312995018 580 6819948
SGTC_2564 betulinic acid 100 µM 1.29768124728577 0.0948304590659759 no 422 0.0971984451177134 604 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_582 0987-0078 156 µM 1.29361295965356 0.0955156416539034 no 423 0.0978995718700853 687 1625765
SGTC_1510 1123-0200 71.5 µM 1.2921156227516 0.0957687388411794 no 424 0.0981585531814761 640 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2818 7996756 12.99 µM 1.2917357766134 0.0958330232088087 no 425 0.098224331595839 441 2241621
SGTC_32 0928-0142 34.1 µM 1.29140255907232 0.0958894423799763 no 426 0.0982820618611874 510 2244242
SGTC_465 cgp-37157 41 µM 1.28722683826183 0.0965985324755987 no 427 0.0990076176914131 412 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1728 st035614 33.7865 µM 1.28216929735361 0.0974625153970068 no 428 0.0998916320055318 613 15945546
SGTC_1921 5740136 50 µM 1.2798976252651 0.0978524259911201 no 429 0.100290571468032 616 1774243
SGTC_450 aminopyrene 156 nM 1.27920447252926 0.0979716263275661 no 430 0.100412530649318 572 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1886 st057356 49.9 µM 1.27612263586829 0.098502893139773 no 431 0.100956085517533 537 24207747
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.27554359464719 0.0986029469257587 no 432 0.101058452075327 595 2333 A French combination drug.
SGTC_127 0180-0333 59.125 µM 1.27346273215702 0.0989631176968459 no 433 0.101426944505136 658 771601
SGTC_2168 5727979 200 µM 1.27224106004024 0.0991750214594253 no 434 0.101643741480353 511 695210
SGTC_3237 9133362 49.47 µM 1.26781531700603 0.0999454620071371 no 435 0.102431955481399 540 43845137
SGTC_949 1165-0505 146 µM 1.26723091738041 0.100047521045594 no 436 0.102536366904734 604 6244267
SGTC_501 nsc-95397 161 µM 1.2651641393822 0.100409071775242 no 437 0.102906247276844 554 262093
SGTC_1424 4048-1941 275 µM 1.26144851089659 0.101061459386422 no 438 0.103573649896859 622 X1424
SGTC_70 0141-0289 43.283 µM 1.26122635486181 0.101100563053314 no 439 0.103613652934913 796 352408
SGTC_2641 levomentholum 100 µM 1.25946907557165 0.101410266133314 no 440 0.103930476611859 505 16666
SGTC_3249 9135183 49.47 µM 1.25452014327297 0.102286178982722 no 441 0.104826504439136 618 4902779
SGTC_2736 butenafine 14.65 µM 1.25386031445562 0.102403376730964 no 442 0.104946390925224 621 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3103 9120822 49.47 µM 1.25069990508493 0.102966077683814 no 443 0.105521992558474 618 17141819
SGTC_2325 6158266 200 µM 1.25068534072054 0.102968676012263 no 444 0.105524650423552 561 3623240
SGTC_591 4299-0174 154 µM 1.25061408487402 0.10298138896615 no 445 0.10553765467043 577 5509088
SGTC_3008 9078912 71.4286 µM 1.24795610821161 0.103456420808058 no 446 0.106023565663225 546 16648731
SGTC_944 3370-0224 231 µM 1.24660278502595 0.103698895990549 no 447 0.106271590022901 584 4580514
SGTC_2569 tetrandrine 100 µM 1.2458989130555 0.103825171739992 no 448 0.106400754598143 516 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3076 9116187 49.47 µM 1.24398228143616 0.104169583773404 no 449 0.106753042084554 539 27241210
SGTC_2775 cyproheptadine 69.59 µM 1.24390333417204 0.104183788060898 no 450 0.10676757105618 597 2913 A selective serotonin reuptake inhibitor.
SGTC_1298 1079-1278 263 µM 1.24296412412889 0.104352879589745 no 451 0.106940527001335 611 2840950
SGTC_2041 5107442 45.335 µM 1.24260186166818 0.104418152960058 no 452 0.107007291779251 594 793005
SGTC_920 mycophenolic acid 780.421 nM 1.23748041084019 0.105344116355273 no 453 0.107954391213967 595 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3084 9116877 49.47 µM 1.23676640759639 0.105473679193687 no 454 0.108086908330533 512 27241325
SGTC_2926 9010726 65.15 µM 1.23409828685926 0.105958855647692 no 455 0.108583140916643 593 2994293
SGTC_2376 9072922 81.32 µM 1.23355967511644 0.106056993231145 no 456 0.108683513538416 608 17087968
SGTC_831 k061-1017 217 µM 1.23353117163234 0.10606218852857 no 457 0.108688827144094 768 1240153
SGTC_263 alizarin 107.927 µM 1.23225107124305 0.106295700557072 no 458 0.108927655478222 681 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2061 5245884 80.95 µM 1.23192277613836 0.106355646931434 no 459 0.10898896623399 616 573863
SGTC_1635 st007035 42.4 µM 1.23172568191789 0.106391647874979 no 460 0.109025786481314 780 3716403
SGTC_2523 spermine 47.74 µM 1.2316088703694 0.106412988655095 no 461 0.109047612903594 576 1103 A DNA binding polyamine.
SGTC_54 0159-0055 9 µM 1.23132508452299 0.106464847529244 no 462 0.109100651819264 584 3319099
SGTC_2438 5259590 200 µM 1.2312390544607 0.106480572220575 no 463 0.109116734299516 625 1201127
SGTC_884 0851-0618 334 µM 1.23002017998986 0.106703539943867 no 464 0.109344774063744 634 9642473
SGTC_1603 st002045 67.8 µM 1.2276497369652 0.107138127630391 no 465 0.109789241172211 597 5887985
SGTC_2463 5473429 200 µM 1.22697603513642 0.107261874088218 no 466 0.109915799164316 585 5399405
SGTC_836 0330-0104 1.35 µM 1.22519243743097 0.107589985186062 no 467 0.110251361602026 605 46494820
SGTC_1074 carmofur 3.8 µM 1.21822194545607 0.108879214159724 no 468 0.111569821142209 665 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1455 4262-0120 131 µM 1.21801804834425 0.108917092472481 no 469 0.111608557119619 629 1529587
SGTC_1079 idarubicin 2.36 µM 1.21708268334482 0.109090978226275 no 470 0.111786379264468 590 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_718 1130-0073 349 µM 1.21604881219999 0.109283408449164 no 471 0.111983164076695 635 6740020
SGTC_1863 st057641 20.1 µM 1.21436324989898 0.109597657954182 no 472 0.112304521242681 657 3921635
SGTC_664 1222-0054 14.9 µM 1.21433555637075 0.109602826437083 no 473 0.112309806588115 639 6813991
SGTC_1146 3579-1023 7 µM 1.20947175695988 0.110513280564176 no 474 0.113240827627327 676 X1146
SGTC_2220 6782180 200 µM 1.20641785520798 0.111087703747168 no 475 0.113828207429418 523 833803
SGTC_1731 st035964 63 µM 1.20629870545993 0.111110158458589 no 476 0.113851168321071 590 6739575
SGTC_458 nppb 133 µM 1.2060612684494 0.111154915031034 no 477 0.113896933739824 586 4549 A chloride channel blocker.
SGTC_2345 9052315 157.45 µM 1.20368501117999 0.111603547693217 no 478 0.114355673870004 615 6469265
SGTC_1038 k292-0204 154 µM 1.2015155303299 0.112014271391993 no 479 0.114775642923757 575 4454212
SGTC_1037 k284-1091 78.7 µM 1.19648901367919 0.112970035711652 no 480 0.115752891660269 566 3334711
SGTC_3309 9129340 25.759 µM 1.19604153010605 0.113055403542091 no 481 0.115840176430903 666 17158987
SGTC_2995 9067767 71.4286 µM 1.19532896033647 0.113191437694187 no 482 0.115979264552786 556 11673567
SGTC_866 0495-0101 262 µM 1.17848870116086 0.116440401292134 no 483 0.119300917084313 610 635694
SGTC_1159 4092-0538 61.2 µM 1.17747609359046 0.116637849163993 no 484 0.119502766964717 679 717301
SGTC_1092 toremifene 6.32 µM 1.1764915454823 0.116830053261105 no 485 0.11969925445942 681 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_676 falcarinol 140 µM 1.17462139934549 0.117195762395778 no 486 0.120073109027861 660 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1903 st060211 78.3 µM 1.17102455728873 0.117901406917322 no 487 0.120794453168077 686 688960
SGTC_2196 6573537 42.6665 µM 1.1650933940082 0.119071564539321 no 488 0.121990595288274 632 2903087
SGTC_965 1291-5240 308 µM 1.16469452829772 0.11915054986209 no 489 0.122071332315352 682 2834598
SGTC_2710 st078562 53.7235 µM 1.16126171147348 0.11983186208242 no 490 0.122767742631213 646 17250908
SGTC_3231 9132313 49.47 µM 1.16076565627721 0.119930540995401 no 491 0.122868606551714 663 4905967
SGTC_1169 aniline yellow 25.8 µM 1.15466169903298 0.121149475441136 no 492 0.124114494895698 624 6051 A DNA damaging agent.
SGTC_2163 5671233 125 µM 1.15220811476917 0.121641892970114 no 493 0.124617781957496 710 701023
SGTC_1665 st014639 11.4 µM 1.1479400559473 0.122501811132633 no 494 0.125496655397209 712 981133 YIL048W NEO1
SGTC_3050 9093513 49.47 µM 1.14676617589331 0.122739067768511 no 495 0.125739136001571 658 25236664
SGTC_2780 5215298 71.43 µM 1.14363542356357 0.123373409491795 no 496 0.126387432255423 713 2834131
SGTC_2729 fluphenazine 10.66 µM 1.14256324448933 0.123591177596712 no 497 0.126609986710216 671 3372 An atypical antipsychotic.
SGTC_3027 9089541 49.47 µM 1.14154723791122 0.123797784890409 no 498 0.126821133060343 679 9943819
SGTC_121 0557-0495 61.343 µM 1.13921018573015 0.124273947260737 no 499 0.127307749100966 841 3104427
SGTC_2258 7960471 200 µM 1.13722829631092 0.124678749633182 no 500 0.127721430419606 566 2974708
SGTC_848 0368-0089 85.6 µM 1.13720030825504 0.124684472805752 no 501 0.127727279071127 693 762535
SGTC_882 0843-0131 351 µM 1.13652234555556 0.124823162951817 no 502 0.127869009505646 720 5425421
SGTC_253 dyclonine 31.25 µM 1.13542206468704 0.125048475663509 no 503 0.12809925953837 729 3180 An oral anasthetic.
SGTC_2237 6667747 47.222 µM 1.13490883746824 0.12515367012161 no 504 0.128206758354853 639 729940 YDL015C TSC13
SGTC_738 1315-0003 72.4 µM 1.13463769725739 0.125209269760232 no 505 0.128263575739907 707 6251474
SGTC_2709 st078560 56 µM 1.13447655462954 0.125242321615682 no 506 0.12829735143255 681 17250903
SGTC_937 3122-0005 46.7 µM 1.13086896273378 0.125983867535978 no 507 0.129055124225268 729 759535
SGTC_1664 st014217 9.02 µM 1.12664045225116 0.126856934667618 no 508 0.129947264299736 731 3982782
SGTC_1228 0124-0032 52.5 µM 1.11963272603447 0.128313088084639 no 509 0.131435151888569 690 X1228
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.1189825713154 0.12844877134846 no 510 0.131573787228062 682 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_421 streptovitacin 30 mM 1.11893288739331 0.128459144170107 no 511 0.131584385698034 722 91467 include heat shock
SGTC_977 1348-1378 135 µM 1.10963079723099 0.130411452348432 no 512 0.133579077293032 712 X977
SGTC_688 0527-0193 473 µM 1.10615092713243 0.131147049898757 no 513 0.134330599489039 667 4007154
SGTC_1591 genipin 88.4 µM 1.10564348354727 0.131254555588755 no 514 0.13444043047548 669 442424 A DNA cross-linking agent.
SGTC_1694 st024011 44.9 µM 1.10532385617889 0.13132230225126 no 515 0.134509642197319 738 2787533
SGTC_2210 7115885 190.385 µM 1.10472727668188 0.131448814923701 no 516 0.134638890221173 725 2927039
SGTC_2652 actinonin 100 µM 1.10377247335855 0.131651468803413 no 517 0.134845924205858 672 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_248 streptozotocin 5.23457 mM 1.10165508515503 0.132101646453251 no 518 0.135305825227663 736 5300 DNA alkylating agent.
SGTC_1430 4049-0248 69.1 µM 1.10049438270394 0.132348873163679 no 519 0.135558387882519 782 22774488
SGTC_2702 st077768 96.8 µM 1.09875351019558 0.132720272139068 no 520 0.135937797645373 631 6484119
SGTC_811 0416-0114 265 µM 1.09781075963427 0.132921698559016 no 521 0.136143566069561 688 6612453
SGTC_191 3914-0123 66.505 µM 1.09706860727787 0.133080413510079 no 522 0.136305701033031 565 3144412
SGTC_1547 harmine 94.2 µM 1.09662515770685 0.133175310820162 no 523 0.136402642660152 779 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_345 1362-0200 395 µM 1.09483358337842 0.133559178160549 no 524 0.136794775277552 664 1419823
SGTC_3321 9137793 26.8275 µM 1.09360401279304 0.133823069022587 no 525 0.137064344270208 716 4904192
SGTC_2446 5162541 200 µM 1.09299592256617 0.133953709918951 no 526 0.137197794998138 673 1549321
SGTC_1819 st053448 58.6 µM 1.09251632619003 0.134056807250569 no 527 0.137303109208592 706 2857616
SGTC_2412 st077135 33.4 µM 1.09245132181889 0.134070785231002 no 528 0.137317387717451 707 13258915
SGTC_1226 3909-7979 35.4 µM 1.09176809603575 0.134217760794254 no 529 0.137467522740511 765 6615510
SGTC_2201 6605497 169.863 µM 1.09025531886875 0.134543583172663 no 530 0.137800345680247 710 670741
SGTC_1606 st000094 49.2 µM 1.08854193976654 0.134913266476742 no 531 0.138177966128358 768 1242210
SGTC_1641 st009299 47.1 µM 1.08830839871476 0.134963709834037 no 532 0.138229492032022 639 4046054
SGTC_2560 caryophyllene 100 µM 1.08675064118551 0.135300506304806 no 533 0.138573513424099 774 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2387 9077560 195.08 µM 1.08488199223958 0.135705278838686 no 534 0.138986962319268 711 5303272
SGTC_2187 6125751 200 µM 1.08452434092607 0.135782845019746 no 535 0.139066190298938 727 874498
SGTC_1045 1348-1485 165 µM 1.08384768883246 0.135929678039793 no 536 0.139216168365324 789 6810614
SGTC_3010 9080089 71.4286 µM 1.08231437616046 0.136262807974534 no 537 0.139556430070016 728 17027233
SGTC_1339 1486-1321 22.7 µM 1.08172514225655 0.136390974329986 no 538 0.13968733892464 727 3469382
SGTC_342 k048-0088 23.3 µM 1.08140877085714 0.136459823410755 no 539 0.13975766092959 704 6820570
SGTC_1127 asiatic acid 681.4 nM 1.0795036964637 0.136874910267634 no 540 0.140181623423751 703 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1281 0884-0031 11.8 µM 1.07791920580171 0.137220803508947 no 541 0.140534906825369 753 1548255
SGTC_3032 9089427 49.47 µM 1.07636374747189 0.137560939286131 no 542 0.140882304489406 693 17173707
SGTC_1244 0416-0015 52.5 µM 1.07591848331585 0.13765841212352 no 543 0.140981857406521 712 96201
SGTC_1012 4112-3522 18 µM 1.07451357406314 0.13796626995193 no 544 0.141296282136867 734 3112398
SGTC_499 genistein 192 µM 1.07438108348981 0.137995326830408 no 545 0.141325958605622 707 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2212 7123476 200 µM 1.07256100831726 0.138394915140195 no 546 0.141734063619174 635 1085715
SGTC_37 0566-0070 1.56 µM 1.0720925670792 0.138497886524124 no 547 0.141839228537266 786 1626686
SGTC_1123 mangostin 811.285 nM 1.07068021387676 0.138808661810567 no 548 0.142156621174396 705 5281650 An antioxidant.
SGTC_2043 5101342 149 µM 1.07058106423497 0.138830496600276 no 549 0.142178920729468 709 678451
SGTC_2960 9079389 5.97 µM 1.06834698658333 0.139323106590507 no 550 0.142682010479621 754 16457355
SGTC_1945 st075991 56.6 µM 1.06771444423431 0.139462796770797 no 551 0.142824670431274 676 1084980
SGTC_210 3551-0445 56.827 µM 1.06743038361645 0.139525559492745 no 552 0.142888767183563 735 2865180 YOR207C RET1
SGTC_717 1532-0246 73.2 µM 1.06545199414256 0.139963214139589 no 553 0.14333571930598 733 9561992
SGTC_680 0417-1641 114 µM 1.06403363912838 0.140277552854443 no 554 0.143656730464278 692 2835990
SGTC_1952 st077036 64.1 µM 1.06346901924084 0.14040281838015 no 555 0.143784653751118 731 2937007
SGTC_1893 st059353 36.1 µM 1.06104858772055 0.140940671378319 no 556 0.144333910353973 728 3112488
SGTC_1678 st019265 80.2 µM 1.06062751345113 0.14103438237036 no 557 0.144429606881515 767 5367020
SGTC_2607 solasodine 47.35 µM 1.06046475210166 0.141070616583151 no 558 0.144466608713753 753 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2626 ethyl orsellinate 100 µM 1.05953492501132 0.141277737341903 no 559 0.144678116177377 698 75653 A natural product.
SGTC_1762 st045503 25.4615 µM 1.05866118744016 0.141472551830911 no 560 0.144877054968092 741 4645554
SGTC_743 1275-0778 158 µM 1.05792583936138 0.141636651066589 no 561 0.14504462692507 788 2849257 YMR203W TOM40
SGTC_1556 plumbagin 1.48 µM 1.05718619423195 0.141801839256451 no 562 0.145213309656466 676 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1495 4469-0029 237 µM 1.05649179681452 0.141957040775006 no 563 0.145371793330032 843 793680
SGTC_1680 diphenhydramine 100 µM 1.05261150710559 0.142826422618721 no 564 0.146259540550528 730 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1906 st060206 94.7 µM 1.0506473147478 0.143267870508324 no 565 0.146710300845208 802 5133468
SGTC_795 0685-0265 78 µM 1.05031085844158 0.143343580661979 no 566 0.14678760723423 777 302754
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.04792026980347 0.143882294155617 no 567 0.147337671250139 907 688664
SGTC_568 1193-0097 7.48 µM 1.04754727234011 0.143966471262527 no 568 0.147423620762545 757 3646150
SGTC_2978 9011784 42.97 µM 1.04632670652652 0.14424215756045 no 569 0.147705109589216 853 2994934
SGTC_1474 0330-0125 5.35 µM 1.04571852835155 0.144379658075636 no 570 0.147845502879454 762 X1474
SGTC_2338 7999974 200 µM 1.04515327670819 0.1445075326866 no 571 0.147976066989827 825 315925
SGTC_1269 0831-0796 3.05 µM 1.04206091214884 0.145208456351026 no 572 0.148691719641112 774 927758
SGTC_1862 st057513 3.81 µM 1.04166169804553 0.145299109741788 no 573 0.148784276380067 746 5393163
SGTC_1531 st059297 52.4 µM 1.04032047913226 0.1456039520329 no 574 0.149095516394789 776 7566702
SGTC_986 1493-0483 84 µM 1.03875514147262 0.145960277175621 no 575 0.149459314436125 753 40079
SGTC_2667 digitoxin 100 µM 1.03836014836904 0.146050283808036 no 576 0.149551207796819 692 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2561 acetosyringone 100 µM 1.0378540699774 0.146165657800959 no 577 0.14966899973873 875 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2567 aureobasidin a 60 nM 1.0345842974174 0.146912564433435 no 578 0.150431545185688 747 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2717 st081029 62.2815 µM 1.03012060351544 0.147936321668199 no 579 0.15147669724148 749 5292846
SGTC_1389 3405-0187 19 µM 1.02996351674543 0.147972436615391 no 580 0.151513566071235 700 799890
SGTC_1122 capsaicin 818.572 nM 1.02989862448535 0.147987357356997 no 581 0.151528798259215 793 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2038 4100038 30.985 µM 1.02813675644701 0.148392850275035 no 582 0.151942751358785 774 3596803
SGTC_1534 6-azauridine 81.6 µM 1.02783108896666 0.148463275044118 no 583 0.152014644713749 823 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1301 naphtanilide LB 4.81 µM 1.02773303928286 0.148485870098501 no 584 0.152037710901441 838 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3069 9117009 49.47 µM 1.0265398290045 0.148761023646597 no 585 0.152318599883493 639 41904981
SGTC_1856 st057054 55.7 µM 1.02645607655632 0.14878034970015 no 586 0.15233832865091 822 1266018
SGTC_1477 0139-0234 16 µM 1.0252553617295 0.149057601640837 no 587 0.15262135608668 792 620880
SGTC_1275 0867-0008 21.1 µM 1.02378592586576 0.149397372141187 no 588 0.152968199713925 786 3422836
SGTC_570 0987-0065 62.6 µM 1.02310472856682 0.149555057330724 no 589 0.153129165733222 681 3104428
SGTC_815 1582-0027 36.9 µM 1.0207212888289 0.15010765559776 no 590 0.153693252662708 787 3128206
SGTC_1519 esterone 74 µM 1.01745030143857 0.150868244115032 no 591 0.154469631604153 782 698 A steroid.
SGTC_2803 7707263 71.43 µM 1.01640142692297 0.151112676615191 no 592 0.154719133207172 745 2199229
SGTC_1527 coumarin 137 µM 1.01148510372583 0.152261900042665 no 593 0.15589215360139 735 323 A hepatotoxic, DNA x-linker.
SGTC_3278 9139605 49.47 µM 1.01112855935787 0.152345469738057 no 594 0.155977451464231 772 7958859
SGTC_373 0844-0104 25.9 µM 1.00808546864495 0.153059972140717 no 595 0.156706716533572 857 5375804
SGTC_1112 tnp00069 1.16933 µM 1.00738473566092 0.153224814852045 no 596 0.156874961887878 843 145826
SGTC_1091 telmisartan 47.6 µM 1.00494290975696 0.153800156860341 no 597 0.157462170421854 817 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2622 2-methoxyxanthone 59.94 µM 1.00267559215551 0.154335659992309 no 598 0.158008705067248 849 71034 A hepatoprotective.
SGTC_2916 7875993 68.79 µM 0.997685058031169 0.155518680388046 no 599 0.159216050471567 802 1299250
SGTC_2670 beta-carotene 100 µM 0.99682363662171 0.15572348663343 no 600 0.159425061533101 752 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2477 5967686 25.23 µM 0.990888939456547 0.157139315389668 no 601 0.160869906880324 789 776118
SGTC_3132 9126706 49.47 µM 0.99015603523247 0.157314748312325 no 602 0.161048928950951 779 850858
SGTC_398 bronopol 33.3 µM 0.990085889865464 0.157331545531497 no 603 0.161066069748899 818 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3002 9075603 71.4286 µM 0.986538394905094 0.158182576830426 no 604 0.161934491945166 827 20105405
SGTC_2910 7948405 25.97 µM 0.986143330124948 0.158277538062031 no 605 0.16203139170786 779 2971328
SGTC_350 k064-0020 19.8 µM 0.984171686017063 0.158752018781305 no 606 0.162515552395256 874 2790705
SGTC_2608 thymoquinone 42.66 µM 0.981544346658564 0.15938574175114 no 607 0.163162188356226 769 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1687 st020778 55.3625 µM 0.98056483282087 0.159622427019082 no 608 0.163403691810369 911 4259299
SGTC_34 0469-0683 81.75 µM 0.980236142612989 0.159701901742433 no 609 0.163484783833531 823 3690923
SGTC_1539 benzyladenosine 56 µM 0.979997885408014 0.159759526655993 no 610 0.163543581229604 794 92208 A nucleotide analog.
SGTC_1444 4112-3581 28 µM 0.979310899765981 0.159925757231064 no 611 0.163713193232736 859 2877249
SGTC_3017 9080681 49.47 µM 0.978576763752045 0.160103521820532 no 612 0.163894572505677 807 16451914
SGTC_1258 0671-0043 57.1 µM 0.976165287076603 0.160688348509201 no 613 0.164491281150734 813 4298767
SGTC_2843 9000894 45.46 µM 0.975825258481206 0.16077092367686 no 614 0.164575532770816 692 2242070
SGTC_1913 st060213 96.1 µM 0.975294796361974 0.160899800510143 no 615 0.164707025470241 862 688959
SGTC_994 3910-0338 138 µM 0.974939346855177 0.16098619540358 no 616 0.164795173540733 853 3479481
SGTC_1486 3970-0793 4.53 µM 0.974497703471856 0.161093582592522 no 617 0.164904739429928 847 2844330
SGTC_341 1486-1430 230 µM 0.971244768347465 0.161885985281117 no 618 0.165713202665284 805 2054753 YPL210C SRP72
SGTC_3292 9120825 59.784 µM 0.967140041173611 0.16288949901337 no 619 0.166737015513262 862 24824900
SGTC_371 0195-0006 7.36 µM 0.963059320597836 0.163891144398197 no 620 0.167758877363465 744 3928593
SGTC_204 PMA1.184 62.41 µM 0.958367706811908 0.165047666993648 no 621 0.168938686624864 891 2252213 YGL008C PMA1
SGTC_3354 9151612 71.43 µM 0.956605733821155 0.165483369776047 no 622 0.16938314683008 871 27261949
SGTC_377 3970-0964 33.1 µM 0.956585258844141 0.165488437222031 no 623 0.169388316079521 928 16481235
SGTC_2319 6033012 152.6 µM 0.955864999894632 0.165666761283449 no 624 0.169570221887653 769 847246
SGTC_2941 9056145 11.23 µM 0.952406252986092 0.166524819355931 no 625 0.17044549473439 782 2119517
SGTC_3122 9126309 49.47 µM 0.952069851973585 0.166608427711582 no 626 0.170530778724697 913 17591206
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.948743630699913 0.167436577276259 no 627 0.171375508785137 831 6710655
SGTC_2407 paclitaxel 400 µM 0.948026046979364 0.167615585699125 no 628 0.171558097139231 863 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1475 4092-1048 11.7 µM 0.946722345712114 0.167941122285127 no 629 0.171890140362926 884 2881759
SGTC_562 3772-2733 112 µM 0.944646406315885 0.168460327494193 no 630 0.172419713367238 930 2876874 YIL048W NEO1
SGTC_859 0439-0102 54.6 µM 0.944638374356004 0.168462338339076 no 631 0.172421764342488 928 610143
SGTC_226 1,3-diallylurea 8.28947 mM 0.943572822440017 0.168729241896594 no 632 0.172693992885749 819 74537 YKL182W FAS1
SGTC_2878 9043973 25.97 µM 0.943391356504575 0.168774723251492 no 633 0.17274038132122 835 6465167
SGTC_665 3914-0008 307 µM 0.942876286809589 0.16890385963309 no 634 0.172872092697382 833 1069549
SGTC_3341 9147222 25.867 µM 0.940318267500858 0.1695461369651 no 635 0.173527166071022 810 1939759
SGTC_1698 5-fluorocytosine 1.055 µM 0.938276098961658 0.170060015839069 no 636 0.17405126967316 886 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1369 1866-0067 208 µM 0.937942728264915 0.170143997896361 no 637 0.174136921615705 914 3531355
SGTC_667 1498-1044 59 µM 0.932828993899558 0.171435568791863 no 638 0.175454134310076 902 6739982
SGTC_1086 cerivastatin 2.18 µM 0.9316266756984 0.171740144618995 no 639 0.175764746108966 857 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1189 1431-2119 7.28 µM 0.928222989057765 0.172604252337711 no 640 0.176645955906983 907 3107275
SGTC_1693 xanthone 101.9 µM 0.927355980733466 0.172824805499318 no 641 0.176870868843002 908 7020 An insecticide.
SGTC_2983 9022671 12.99 µM 0.924888685314268 0.173453428632533 no 642 0.177511906370572 848 6405161
SGTC_63 0099-0242 26.702 µM 0.923136584012191 0.173900715555752 no 643 0.177968015848662 945 3898502 YLR359W ADE13
SGTC_51 1013-0126 23.419 µM 0.919088417940672 0.174936957848812 no 644 0.179024663390977 867 1627850
SGTC_477 mead ethanolamide 10 µM 0.916583990369463 0.175579994475361 no 645 0.179680338397765 770 16061185
SGTC_2203 7227154 166.4 µM 0.915408092479546 0.17588243403167 no 646 0.179988715804675 917 896304
SGTC_427 1354-0053 47.3 µM 0.915260978700021 0.175920294730213 no 647 0.180027319542568 863 6813657
SGTC_3295 9122362 53.5725 µM 0.915243021080283 0.175924916595164 no 648 0.180032032110076 826 4730473
SGTC_151 3013-0144 2.285 µM 0.913448729602471 0.176387112277607 no 649 0.180503293429296 897 906558 YHR107C CDC12
SGTC_2963 9082507 9 µM 0.912655345879901 0.176591726545521 no 650 0.180711918024661 821 16459611
SGTC_1108 betulinic acid 729.144 nM 0.911330939503744 0.176933626236703 no 651 0.181060514606756 893 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2881 9058953 51.95 µM 0.909768534264892 0.177337503529588 no 652 0.181472296066201 961 17122249
SGTC_3230 9131665 49.47 µM 0.907340808672617 0.177966217619492 no 653 0.182113300104049 824 15943720
SGTC_3180 9109287 49.47 µM 0.90700020887988 0.178054535885192 no 654 0.182203343385491 845 18891271
SGTC_1523 st012844 44.7 µM 0.906856452140696 0.178091820611227 no 655 0.182241356245667 887 4274103
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.906689600735564 0.178135101337457 no 656 0.182285482124527 875 6708514
SGTC_3259 9138485 49.47 µM 0.906004876111568 0.178312786165767 no 657 0.182466635772261 971 17646153
SGTC_1479 0549-0158 134 µM 0.905932439391786 0.178331589896557 no 658 0.182485806513299 937 5440202
SGTC_1231 0242-0792 125 µM 0.905353655429953 0.178481880361641 no 659 0.182639029775015 899 3707635
SGTC_785 1270-0111 65.3 µM 0.904933454801514 0.178591042114072 no 660 0.182750321101019 942 6741994
SGTC_2958 9077254 16.72 µM 0.901631179886194 0.179450386134573 no 661 0.183626411069114 873 16457351
SGTC_3196 9111891 49.47 µM 0.901339341131316 0.179526455528614 no 662 0.183703961238133 908 18891510
SGTC_2774 tamoxifen 10.92 µM 0.900160887588355 0.179833832116046 no 663 0.184017318632047 906 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2297 7971671 152.32 µM 0.899466662773961 0.180015061734652 no 664 0.18420207257396 894 909016
SGTC_557 1315-0110 16.2 µM 0.89787718594701 0.180430431439801 no 665 0.184625514355202 951 6833801
SGTC_1759 st043059 70 µM 0.893425506694773 0.181596962501401 no 666 0.185814674171961 915 669426
SGTC_2556 citropten 84.59 µM 0.893370149626555 0.18161149807698 no 667 0.185829491332108 983 2775 A potential DNA crosslinker.
SGTC_855 0428-0020 25 µM 0.893227749964877 0.181648892510935 no 668 0.185867610131503 829 6812414
SGTC_3241 9133421 49.47 µM 0.89313401102627 0.181673511171886 no 669 0.18589270564522 934 17018221
SGTC_974 1326-0144 138 µM 0.891164861376198 0.18219115150086 no 670 0.186420366208502 936 5411856
SGTC_630 4356-0227 183 µM 0.890994642955536 0.182235940925225 no 671 0.186466022085721 888 779312
SGTC_2173 5763948 167 µM 0.887652497395162 0.183116750357231 no 672 0.187363852701196 943 2867177
SGTC_2141 5621638 7.665 µM 0.887340127941205 0.183199209596183 no 673 0.187447903658374 935 2856238
SGTC_765 1319-0117 244 µM 0.88719206919303 0.183238302209888 no 674 0.187487750774879 909 3487746 YGL099W LSG1
SGTC_3058 9093861 49.47 µM 0.885134649514077 0.1837820702532 no 675 0.18804200671886 914 17217477
SGTC_602 3130-1533 38.1 µM 0.884994669518461 0.183819102908767 no 676 0.188079753162567 978 720941
SGTC_930 2810-3379 265 µM 0.884822399651189 0.183864684447987 no 677 0.188126213182307 991 1015764
SGTC_2433 5607874 27.82 µM 0.884813300796067 0.183867092144372 no 678 0.188128667279 928 2252428
SGTC_1447 4239-0816 81.9 µM 0.882273964734517 0.184539806666754 no 679 0.188814336046641 864 1341554
SGTC_411 enrofloxacin 100 µM 0.880420662860688 0.185031743717916 no 680 0.189315733454026 988 71188 A bacterial gyrase inhibitor.
SGTC_1656 st012921 11 µM 0.880032231300359 0.185134951459302 no 681 0.189420924602492 867 6732821
SGTC_3083 9117465 49.47 µM 0.878782518948877 0.185467247300522 no 682 0.189759603167359 976 16420915
SGTC_3161 9100388 49.47 µM 0.87858080934136 0.185520916131342 no 683 0.189814302407038 983 25236368
SGTC_1564 D-Arginine 115 µM 0.878009233844797 0.185673047443008 no 684 0.18996935385252 912 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_594 1487-1584 10.8 µM 0.877386637377714 0.185838846608125 no 685 0.190138334333913 949 5013332
SGTC_1082 camptothecin 424.86 nM 0.872404172596653 0.187168996319878 no 686 0.191493962507833 869 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_300 r073-0011 5.04 µM 0.87124037566067 0.187480536981111 no 687 0.191811459255233 1005 2735780
SGTC_1208 2323-2347 50.3 µM 0.870486903934973 0.187682407132895 no 688 0.192017186495474 963 5412760
SGTC_1149 3909-7961 23.3 µM 0.869750358990992 0.18787987199514 no 689 0.192218422526466 929 735261
SGTC_38 0929-0051 58.268 µM 0.869184227225338 0.188031736906448 no 690 0.192373186565666 1000 1379719
SGTC_1218 1348-1416 30.7 µM 0.867043639169379 0.188606634514171 no 691 0.1929590498048 967 6787668
SGTC_2639 lactacystin 53 µM 0.863238790392528 0.189631174042605 no 692 0.194003095128023 962 3870 A proteasome inhibitor.
SGTC_966 1300-0360 30.2 µM 0.86242405171127 0.189851004652754 no 693 0.194227104940027 915 70588
SGTC_186 3455-3465 67.277 µM 0.860794243311404 0.190291225187757 no 694 0.194675688070945 900 755278
SGTC_1027 k015-0025 8.67 µM 0.860680718655877 0.190321912185753 no 695 0.194706957690462 946 3598955
SGTC_2735 sertaconazole 140 nM 0.86056326532478 0.190353664348275 no 696 0.194739312653711 945 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2773 thioridazine 9.09 µM 0.860041153332346 0.190494850718309 no 697 0.194883178843201 1031 5452 An antipsychotic.
SGTC_3334 9142812 21.919 µM 0.859565083687863 0.190623642622216 no 698 0.195014414539966 918 45283678
SGTC_2863 9028737 58.44 µM 0.857995414272175 0.191048666383278 no 699 0.195447497799468 971 6460917
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.856383116871282 0.191485837176744 no 700 0.195892950075864 1146 16725076
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.856374207492361 0.191488254636223 no 701 0.195895413306595 946 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_520 3584-0023 682 µM 0.855924862195204 0.191610203667079 no 702 0.19601967093761 885 1340790
SGTC_2004 4023728 41.89 µM 0.854053380651754 0.192118621543225 no 703 0.196537706500462 983 360084 YDR527W RBA50
SGTC_3300 9124615 50.48 µM 0.853314839386064 0.192319485006278 no 704 0.196742366519545 957 24824903
SGTC_1981 st071826 47 µM 0.853048397283917 0.192391981642984 no 705 0.196816232988997 905 11838600
SGTC_2249 haloperidol 116.36 µM 0.852094015740367 0.192651797868903 no 706 0.197080956561167 1049 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1147 3809-1045 12.3 µM 0.849333201168939 0.193404595185823 no 707 0.197847955645078 947 325925
SGTC_1266 0828-0227 32.9 µM 0.849186647257959 0.193444606459851 no 708 0.197888721042164 937 3913820
SGTC_3153 9100258 49.47 µM 0.849070361429659 0.193476357715417 no 709 0.197921070687437 896 25236848
SGTC_3119 9125183 49.47 µM 0.848738624662969 0.19356695422653 no 710 0.198013374350699 841 22695334
SGTC_726 3448-4391 34.2 µM 0.848610517099134 0.193601947017258 no 711 0.198049026429497 1010 1356692
SGTC_2605 digitonin 300 nM 0.847733693447994 0.193841556384878 no 712 0.19829314874383 1062 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3340 9146634 11.102 µM 0.847548758638648 0.193892116544456 no 713 0.198344660858865 961 4907387
SGTC_2860 9025725 38.96 µM 0.845504189891839 0.194451625867505 no 714 0.198914697160627 914 40546248
SGTC_2375 9072683 200 µM 0.844814847639633 0.194640490108063 no 715 0.19910711168778 1069 16798029
SGTC_1843 st055809 45.5 µM 0.843227015484763 0.195075944773697 no 716 0.199550746048123 925 16413835
SGTC_1707 st032323 6.317 µM 0.841192864177057 0.195634664621125 no 717 0.200119948735987 964 3132057 YMR211W DML1
SGTC_1311 1190-0148 100 µM 0.83905663165377 0.196222467809334 no 718 0.200718765511995 1090 1961333
SGTC_823 0417-1665 178 µM 0.838176459787536 0.196464966023653 no 719 0.200965802924497 987 3429856
SGTC_2283 7944793 200 µM 0.836732544632683 0.196863175606574 no 720 0.201371460737827 1028 2970533
SGTC_2858 9025781 8.96 µM 0.83260608869084 0.19800387964188 no 721 0.202533461983703 1075 4894980 YPL153C RAD53
SGTC_2571 chrysanthemic acid 100 µM 0.832166645957681 0.198125592504524 no 722 0.202657443853143 932 2743 An insecticide.
SGTC_3317 9138495 8.753 µM 0.831447706135766 0.198324815314422 no 723 0.202860379217955 1024 17020139
SGTC_834 0312-0008 75.7 µM 0.83011163487417 0.198695370136555 no 724 0.203237834727216 991 6385573 YIL048W NEO1
SGTC_2012 4023501 200 µM 0.828971338064872 0.199011957553269 no 725 0.20356031300477 934 3477460
SGTC_2403 6032726 181.2 µM 0.828718795458892 0.19908211355722 no 726 0.203631773827427 968 2881040
SGTC_2868 9035608 32.47 µM 0.828587698871295 0.199118537891185 no 727 0.203668875525027 1020 6462614
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.827936084071713 0.1992996443876 no 728 0.203853349089266 1076 5282309
SGTC_1363 1636-0063 10.4 µM 0.824802841050069 0.200171866315239 no 729 0.204741766730424 1037 6072185
SGTC_3348 9149464 3.537 µM 0.823146099457649 0.200633990407071 no 730 0.205212458057418 1028 1951442
SGTC_3077 9117319 49.47 µM 0.821821559796509 0.201003911925784 no 731 0.205589230675582 1018 17154678
SGTC_2812 7970281 58.44 µM 0.821471414135546 0.201101770018208 no 732 0.205688900127744 1010 2233435
SGTC_2451 5856223 45.7 µM 0.820172829601947 0.201464945547367 no 733 0.206058794356279 985 2179896
SGTC_2358 9037157 4 µM 0.819778594831024 0.201575279029308 no 734 0.206171167837506 1001 2388925
SGTC_576 1073-0113 22.7 µM 0.819576692049869 0.201631799061445 no 735 0.206228732682235 1215 5439563
SGTC_2421 5690543 90.72 µM 0.818795242342101 0.201850645105604 no 736 0.20645162291674 995 3397993
SGTC_712 r015-0009 80.6 µM 0.815215821107101 0.202854883070591 no 737 0.207474391646707 959 6813872 YLR060W FRS1
SGTC_847 0342-0274 5.54 µM 0.812780284862096 0.203539897225726 no 738 0.208172020479647 1060 18097
SGTC_518 1021-0119 62.6 µM 0.812770976342609 0.20354251796551 no 739 0.208174689441049 932 1097762
SGTC_1799 st045822 46.1415 µM 0.811074696094308 0.204020428135415 no 740 0.208661388081482 1016 3674992
SGTC_2512 diallyl trisulfide 49.23 µM 0.809547628958217 0.204451235484789 no 741 0.209100109054238 1040 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1191 1487-1166 10.6 µM 0.807257750394313 0.205098256512039 no 742 0.20975899997803 1105 3955771
SGTC_2075 5212009 200 µM 0.806860757193383 0.205210553335345 no 743 0.209873355052869 944 780898
SGTC_3028 9087778 49.47 µM 0.806133287475331 0.205416426297571 no 744 0.210082999944905 1045 17217395
SGTC_215 1287-0124 461.5 µM 0.804873909600933 0.205773118396142 no 745 0.210446222791182 1021 5560863
SGTC_1857 st056007 79.3 µM 0.802785506449633 0.206365423752178 no 746 0.211049360361122 1025 619834
SGTC_1075 aripiprazole 15.2 µM 0.801866364679116 0.206626427271703 no 747 0.211315132249225 1093 60795 An atypical antipschotic. YIL048W NEO1
SGTC_362 0310-0100 9.03 µM 0.799460519804784 0.207310526415559 no 748 0.212011715160704 1011 790235
SGTC_987 1497-1013 404 µM 0.799075959237487 0.207419999767223 no 749 0.212123184314381 1061 1676435
SGTC_2575 plumbagin 510 nM 0.798069919314118 0.207706552037556 no 750 0.212414958193872 988 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3078 9116413 49.47 µM 0.796333046735372 0.2082018188042 no 751 0.21291924124771 1033 17177322
SGTC_2750 bromebric acid 70.15 µM 0.792065473869231 0.20942166677857 no 752 0.214161250215925 1069 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2628 lathosterol 100 µM 0.790494263845578 0.209871840297428 no 753 0.214619585432403 1102 6710616
SGTC_3247 9135149 49.47 µM 0.790049726245712 0.209999309654809 no 754 0.214749364197154 990 8934436 YOR116C RPO31
SGTC_2361 9034121 116 µM 0.789494956104143 0.210158451543284 no 755 0.214911388307775 1028 6496917
SGTC_1782 st039423 80.636 µM 0.789115373361973 0.210267379813237 no 756 0.215022288734868 981 2068169
SGTC_2950 9072895 21.46 µM 0.788704055737848 0.210385452413444 no 757 0.215142498459117 1068 17332245
SGTC_217 ketoconazole 989 nM 0.788242341815985 0.210518038104869 no 758 0.215277483228593 1029 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_118 0083-0097 135.343 µM 0.787944319116806 0.210603644288317 no 759 0.215364638004545 1172 5207356
SGTC_521 r062-0005 13.8 µM 0.78697606348964 0.210881913949008 no 760 0.215647939250711 1005 2832033
SGTC_3252 9135871 49.47 µM 0.786800269349942 0.210932459028318 no 761 0.215699397903293 1094 17682838
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.784512683545129 0.211590842797605 no 762 0.216369671270948 1077 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2948 9070189 9.45 µM 0.783926230485284 0.211759821776381 no 763 0.216541698713433 977 6473636 YDL196W YDL196W
SGTC_2035 5154463 94.595 µM 0.780699869001702 0.212690867998625 no 764 0.217489518845561 1065 2769623
SGTC_14 0354-0009 295 µM 0.780288546779119 0.212809736721582 no 765 0.21761052637418 1085 1713507
SGTC_1425 4048-4433 7.33 µM 0.778647661315776 0.213284324825802 no 766 0.218093647524946 1136 23734946
SGTC_529 4076-0302 30.3 µM 0.778367659160741 0.21336537055535 no 767 0.218176149454094 1010 5816522
SGTC_1058 3448-5425 97.3 µM 0.778300022324077 0.213384950513556 no 768 0.218196081174214 1031 7279705
SGTC_2020 4017018 200 µM 0.778067900429445 0.213452154657758 no 769 0.218264492539408 1088 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1668 st014914 51.6 µM 0.775310733559025 0.21425135517211 no 770 0.219078034193445 1090 2839556
SGTC_146 3448-8650 53.125 µM 0.772316551708126 0.215121226055578 no 771 0.219963482290956 1118 2891488 YIL048W NEO1
SGTC_549 1661-1316 519 µM 0.771091696112561 0.215477661663025 no 772 0.22032629111824 1115 2857282
SGTC_1712 st032288 53.4 µM 0.770569341245036 0.215629772185656 no 773 0.220481119733577 1114 2883011
SGTC_2722 naftopidil 47.16 µM 0.770248539871565 0.215723220880049 no 774 0.220576237774335 1101 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2737 bleomycin 30.5 nM 0.768688710436076 0.216177930037029 no 775 0.221039064249851 1134 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_885 0865-0106 16.8 µM 0.768215610283043 0.216315954075644 no 776 0.221179550442038 1100 2793380
SGTC_1344 1488-0097 29.1 µM 0.767670372077749 0.216475087200738 no 777 0.221341521232952 1058 747966
SGTC_394 menadione 8.33 µM 0.767017185230072 0.216665815354824 no 778 0.221535648983019 1073 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3123 9126162 49.47 µM 0.765171647804857 0.217205230456992 no 779 0.222084670087308 1171 25239884
SGTC_326 k292-0812 17.5 µM 0.764008895764574 0.217545478479782 no 780 0.222430970701277 1088 3579357
SGTC_1951 sophoraflavanone G 9.2 µM 0.763172534540164 0.217790407136052 no 781 0.222680253171207 1123 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1087 pterostilbene 9.05 µM 0.762104781666419 0.218103329957844 no 782 0.222998734606896 1108 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2591 skatole 100 µM 0.76207006624354 0.218113508240541 no 783 0.223009093619227 1087 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3087 9117406 49.47 µM 0.761297872867235 0.218339979889287 no 784 0.223239585405573 1092 42546093
SGTC_3291 9121177 71.43 µM 0.761276934073437 0.218346122779781 no 785 0.223245837308042 1019 17015612
SGTC_260 nsc-65238 3.989 µM 0.760579458491065 0.218550800625738 no 786 0.223454146422569 1072 3246252
SGTC_1769 st044406 64.4 µM 0.758745942348516 0.219089382090585 no 787 0.224002274232772 1093 670903
SGTC_2157 5649910 96.377 µM 0.758077510427287 0.219285918569715 no 788 0.224202291127932 1088 2858091
SGTC_1022 4477-0945 21.3 µM 0.757238769154123 0.219532673742927 no 789 0.224453413613289 1071 4648966
SGTC_2669 eugenol 100 µM 0.756994227436131 0.219604647202669 no 790 0.22452666042273 1075 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1299 1079-1439 3.74 µM 0.75622544283167 0.219831003950223 no 791 0.224757020368447 1097 323161
SGTC_1290 0986-0249 10.2 µM 0.756182461992465 0.219843662945795 no 792 0.224769903175998 1097 53329
SGTC_2690 usnic acid 100 µM 0.753968428384787 0.220496320150822 no 793 0.225434089824957 1151 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_796 1234-0020 70.7 µM 0.75202649749505 0.221069679289275 no 794 0.22601756206181 1106 46495034
SGTC_1808 st050063 61.5 µM 0.746768946585598 0.222626256649987 no 795 0.227601521681933 1110 4011993
SGTC_2951 9072950 58.06 µM 0.745085006778756 0.223126130389476 no 796 0.228110166178309 1178 16488155
SGTC_462 ag-879 158 µM 0.744129161893799 0.223410154874355 no 797 0.228399169227956 1148 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1328 1441-0025 69.2 µM 0.743109924955174 0.223713242483353 no 798 0.228707565625865 1088 4562601
SGTC_1485 3909-9022 254 µM 0.742770112714273 0.223814343427755 no 799 0.228810436521469 1159 714516
SGTC_991 3996-0057 64.7 µM 0.741968316273402 0.224052996821677 no 800 0.229053266176819 1073 715343
SGTC_740 k014-0057 261 µM 0.741606905440446 0.224160617409982 no 801 0.229162769225119 1129 4012779
SGTC_745 0469-0705 296 µM 0.74151136972577 0.224189070853103 no 802 0.229191720280035 1210 3486736
SGTC_1150 3909-7983 10.9 µM 0.741245363042268 0.224268306543086 no 803 0.229272341505559 1125 23965914
SGTC_2135 5326629 150.42 µM 0.740574119211248 0.22446832131373 no 804 0.2294758525532 1100 5020077
SGTC_1376 2910-0861 41.3 µM 0.740133484612264 0.22459967501008 no 805 0.229609501364096 1134 1112859
SGTC_413 propylparaben 100 µM 0.739994268966154 0.224641184422119 no 806 0.229651735902731 1112 7175 A pharmaceutical preservative.
SGTC_391 gliotoxin 8.33 µM 0.738990604290255 0.224940572132959 no 807 0.229956351356004 1143 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1743 st037606 46.3785 µM 0.737312180735399 0.225441741729484 no 808 0.230466263245906 1129 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2713 st079149 53.4 µM 0.735078785179936 0.226109602563522 no 809 0.231145756872516 1128 3103253
SGTC_3091 9116372 49.47 µM 0.734666074781403 0.226233139226717 no 810 0.23127144313885 1127 17169793
SGTC_2684 capsaicin 100 µM 0.734562184759254 0.226264242648814 no 811 0.231303087670787 1137 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1841 st054148 70 µM 0.734324045143829 0.226335547897903 no 812 0.231375633264447 1089 675442
SGTC_1441 4106-0040 13 µM 0.733890267311992 0.22646546497332 no 813 0.231507809651957 1142 2904180
SGTC_1679 SEC14.276 6.7 µM 0.733056047379998 0.226715433344925 no 814 0.23176212298264 1167 1005053 YMR079W SEC14
SGTC_802 4112-3352 742 µM 0.731252905188169 0.227256264348913 no 815 0.23231234529425 1164 704594
SGTC_189 3970-0742 2.116 µM 0.730981223590661 0.227337814984118 no 816 0.232395310902846 1158 2891807
SGTC_451 chloral hydrate 100 µM 0.729254115710557 0.227856626171419 no 817 0.232923117036913 1204 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1806 st050005 60.3 µM 0.727054320927469 0.228518392831243 no 818 0.233596339913653 1129 5194765
SGTC_623 k072-0108 16.9 µM 0.726121913657019 0.228799215394401 no 819 0.233882018115306 1119 5382803
SGTC_793 0488-0545 106 µM 0.725826944194416 0.228888094661117 no 820 0.233972433448115 1136 292548
SGTC_128 0906-2981 13.371 µM 0.724280021007072 0.229354525807834 no 821 0.234446920030311 1100 6740226
SGTC_2174 5790901 200 µM 0.723321315214567 0.229643863777853 no 822 0.234741250148115 1160 786020
SGTC_3104 9120930 49.47 µM 0.723099039081014 0.229710976030753 no 823 0.234809519807311 1137 17014836
SGTC_993 3909-8757 62.7 µM 0.722827280764391 0.229793043455236 no 824 0.234893002282304 1078 4288324 YLR208W SEC13
SGTC_1030 k029-0042 36.7 µM 0.719361419461651 0.230841126484145 no 825 0.235959130789832 1162 6080581
SGTC_1978 st071761 42 µM 0.718067833275531 0.231232992456235 no 826 0.236357731307137 1108 5147680
SGTC_764 1951-2361 146 µM 0.717673115160869 0.231352638242002 no 827 0.23647943195594 1144 5438930
SGTC_661 1304-0007 33.6 µM 0.715214618224869 0.232098627285147 no 828 0.237238218783031 1157 3117130
SGTC_2598 perillyl alcohol 100 µM 0.714026152896665 0.232459726390024 no 829 0.237605503889715 1160 10819 An apoptosis inducer.
SGTC_2308 7584454 197.62 µM 0.710106643604542 0.233652827739105 no 830 0.238819003395444 1209 893577
SGTC_88 0180-0332 8.668 µM 0.708860555416037 0.234032847895013 no 831 0.23920550747373 1224 3101745
SGTC_3204 9114183 49.47 µM 0.706998510213363 0.234601354234006 no 832 0.239783701800103 1192 17027248
SGTC_2050 5263056 171 µM 0.706631184653301 0.234713593579119 no 833 0.239897852144403 1193 763468 YGL055W OLE1
SGTC_1264 0783-0040 158 µM 0.705521486919616 0.235052851109391 no 834 0.240242882531023 1120 2855798
SGTC_2192 5915882 198.485 µM 0.705014431528507 0.235207958542328 no 835 0.240400627603486 1142 2876149
SGTC_1308 1187-1617 41.4 µM 0.704492582204527 0.23536765041447 no 836 0.240563033965707 1196 2882570
SGTC_2856 9022925 19.48 µM 0.70431403727873 0.235422300944591 no 837 0.240618613203439 1168 4944862
SGTC_3054 9094397 49.47 µM 0.702901847799855 0.235854802416474 no 838 0.241058459771577 1186 2598354
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.701148339264343 0.236392446367017 no 839 0.241605222928485 1211 4213774
SGTC_827 3253-0474 693 µM 0.700774751359081 0.236507079423905 no 840 0.241721798675672 1189 5402065
SGTC_787 4152-0075 138 µM 0.700275955510114 0.236660179414396 no 841 0.241877492352669 1160 9566539
SGTC_749 1000-0129 128 µM 0.699321625163652 0.236953252674363 no 842 0.242175527719641 1249 708470
SGTC_283 0987-0079 11.7 µM 0.697023073155762 0.237659952372249 no 843 0.242894177165758 1218 411556
SGTC_753 1322-0200 289 µM 0.696292875723144 0.23788469650938 no 844 0.243122716935432 1227 5403907
SGTC_1177 0983-0204 23.6 µM 0.696222895184836 0.237906241617992 no 845 0.243144625795502 1223 766818
SGTC_2369 9071472 200 µM 0.693825109503277 0.238645100764592 no 846 0.243895946891874 1226 17296037
SGTC_901 1112-0062 60.1 µM 0.690407167110146 0.239700480540033 no 847 0.244969085431216 1220 1908457
SGTC_943 3253-1379 105 µM 0.688414985279278 0.240316792125983 no 848 0.24559574489841 1200 668464
SGTC_635 k038-0028 24.7 µM 0.688216484079138 0.240378248737411 no 849 0.245658232448403 1228 4035102
SGTC_2923 7992654 58.14 µM 0.687947421324894 0.240461565098615 no 850 0.245742946180765 1219 2985126
SGTC_858 0438-0351 2.77 µM 0.687589282292292 0.24057248868139 no 851 0.2458557296841 1214 2799119
SGTC_2133 5320837 200 µM 0.686829823117565 0.240807802139372 no 852 0.246094986982982 1180 2841355
SGTC_3183 9108214 49.47 µM 0.686510329067975 0.240906832692872 no 853 0.246195676552778 1113 4974831
SGTC_2413 inermin 26.06 µM 0.685976942509273 0.241072210839972 no 854 0.246363824244204 1257 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.682796536840567 0.242059585567949 no 855 0.247367709166479 1249 23665772 A membrane-active detergent.
SGTC_2953 9074162 66.49 µM 0.682725306484635 0.242081724510536 no 856 0.24739021780801 1168 16451992
SGTC_467 ro 31-8220 72.8 µM 0.682253240866015 0.242228473883088 no 857 0.247539417206459 1174 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2300 7976697 71.57 µM 0.681299535972257 0.24252509581189 no 858 0.24784098842807 1146 2236109
SGTC_2363 9053361 176 µM 0.680837312523504 0.242668927602881 no 859 0.247987218730418 1255 6469797 YMR079W SEC14
SGTC_2156 5649887 115 µM 0.679237750322744 0.24316702556593 no 860 0.248493615825132 1268 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1732 st034308 51.822 µM 0.677772408491199 0.243623812490074 no 861 0.248958003947626 1140 830119
SGTC_2580 diallyl disulphide 81.36 µM 0.677209089687609 0.24379953751504 no 862 0.249136650686238 1226 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_163 TUB2.036 7.546 µM 0.676262120233714 0.244095094913207 no 863 0.24943711913241 1249 15992207 YJR013W GPI14
SGTC_856 0433-0016 11.3 µM 0.675534015012497 0.244322474223302 no 864 0.249668274004605 1233 3911780
SGTC_550 4123-0385 25.7 µM 0.674604974325635 0.244612769171818 no 865 0.249963385893898 1231 5731123
SGTC_2054 5233173 129 µM 0.673401500702867 0.244989091472928 no 866 0.250345947075223 1235 6889
SGTC_1729 st035615 45.989 µM 0.672473702768177 0.245279423370715 no 867 0.250641087985881 1205 17385451
SGTC_1041 0206-0046 107 µM 0.67191940580234 0.245452965405483 no 868 0.25081750276793 1235 50494
SGTC_1217 1183-1422 255 µM 0.671301820866041 0.245646399630108 no 869 0.251014137461079 1259 2849664
SGTC_1632 st005650 90 µM 0.670647021637551 0.245851579151944 no 870 0.25122270997873 1231 2759605
SGTC_792 4534-1957 155 µM 0.6686245967917 0.246485880752006 no 871 0.251867489095488 1220 1717904
SGTC_652 0437-0092 114 µM 0.666823528882701 0.247051494559419 no 872 0.25244243084507 1226 3091274
SGTC_919 tnp00227 403.569 nM 0.666410245076319 0.247181381561763 no 873 0.252574457913485 1251 1269246 A methoxyflavone. YNL221C POP1
SGTC_2696 st077691 74.316 µM 0.665454342613348 0.247481942840763 no 874 0.252879968495782 1233 757133
SGTC_861 0443-0273 110 µM 0.665160799730527 0.247574279744829 no 875 0.252973825098985 1250 6149169
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.664325571799674 0.247837109850649 no 876 0.253240978854964 1233 15053
SGTC_24 0417-1663 219 µM 0.663609239437316 0.248062644416521 no 877 0.253470221115234 1224 4329390
SGTC_2593 nobiletin 86.24 µM 0.661247990375558 0.248806849510805 no 878 0.25422664470483 1208 72344 An anti-infammatory.
SGTC_3139 9095020 49.47 µM 0.660803885458296 0.248946952668333 no 879 0.254369045367354 1077 25236292
SGTC_770 0389-1121 67.2 µM 0.659878865402375 0.249238906366234 no 880 0.254665783932759 1322 6753108
SGTC_423 5-fluorouracil 457 µM 0.659104633152098 0.249483408499098 no 881 0.254914290348366 1229 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_614 0462-0418 107 µM 0.656631469871727 0.250265285221559 no 882 0.255708954382055 1162 5188303
SGTC_1000 4048-0884 8.67 µM 0.655710723190442 0.250556705683315 no 883 0.256005134016589 1255 13040088
SGTC_957 1187-1561 14.1 µM 0.654024467412794 0.251090878998132 no 884 0.256548021154558 1238 1538454
SGTC_1418 3966-3099 2.4 µM 0.653790501925663 0.251165042318163 no 885 0.256623393284692 1265 740335
SGTC_692 k241-0027 77.8 µM 0.650598059723457 0.252178151967777 no 886 0.25765299159617 1331 3600480
SGTC_877 0771-0151 33.1 µM 0.649044047346983 0.252672090787621 no 887 0.258154952985485 1283 6166523
SGTC_1212 0520-0165 585 µM 0.648978789905824 0.252692843838726 no 888 0.258176042872483 1426 5403258
SGTC_3090 9117696 49.47 µM 0.648753762297407 0.252764413587994 no 889 0.258248774100759 1243 7923821
SGTC_2779 methotrexate 400 µM 0.64836948619191 0.252886656793546 no 890 0.25837300062308 1313 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_666 0272-0154 136 µM 0.648036129189519 0.252992727173494 no 891 0.258480791391553 1289 6870312
SGTC_1615 st002656 86.5 µM 0.647650605647769 0.253115425534555 no 892 0.258605479215865 1273 1584458
SGTC_605 1315-0399 119 µM 0.647549754680264 0.253147527956489 no 893 0.258638102045138 1314 24020461
SGTC_303 1348-1668 34.2 µM 0.647436240088922 0.253183663967176 no 894 0.258674823796601 1288 5380509
SGTC_2238 6671620 73.2395 µM 0.647426035242576 0.253186912690691 no 895 0.258678125176945 1239 729941
SGTC_681 1642-0006 26.6 µM 0.64697362556895 0.253330959810338 no 896 0.258824506611234 1264 4446530
SGTC_2069 5228469 200 µM 0.646446646728516 0.25349880403581 no 897 0.258995069632858 1238 2835210
SGTC_583 1488-1091 88.9 µM 0.646164895753145 0.253588566470381 no 898 0.259086285558458 1354 4303273
SGTC_1583 clindamycin 39.6 µM 0.642955437776804 0.254612237925944 no 899 0.260126507795498 1209 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2761 levamisole 97.89 µM 0.641149430108551 0.255189222616857 no 900 0.260712800817945 1321 26879 An alkaline phosphatase inhibitor.
SGTC_2965 9082772 38.63 µM 0.641114397271548 0.255200421690176 no 901 0.260724180417312 1311 16459634
SGTC_1439 4092-1168 46 µM 0.640172237049862 0.255501701810626 no 902 0.261030315013451 1285 2886240
SGTC_2121 5257820 149.641 µM 0.640026979122733 0.255548168320806 no 903 0.261077529873857 1316 791256
SGTC_2740 felodipine 17.08 µM 0.639578993503894 0.255691502087978 no 904 0.261223171452457 1246 3333 L-type calcium channel blocker
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.639328865502606 0.255771549229672 no 905 0.261304507035228 1318 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2292 7671323 168.05 µM 0.637119251702596 0.256479248085945 no 906 0.262023584721716 1273 937504
SGTC_1476 4112-3294 3.34 µM 0.635149955683688 0.257110836241123 no 907 0.262665309270991 1335 704369
SGTC_1868 st057644 42.7 µM 0.635101027767115 0.257126538582502 no 908 0.262681263395668 1286 688665
SGTC_639 0833-0042 114 µM 0.634346261971886 0.257368827270642 no 909 0.262927435744609 1267 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2014 4013930 200 µM 0.629862981761918 0.258810454443845 no 910 0.264392117234324 1275 64556
SGTC_1377 2944-0135 198 µM 0.629554273804768 0.258909874995455 no 911 0.26449312432246 1367 1894137
SGTC_2464 5717415 7.67 µM 0.628305353844611 0.259312295898569 no 912 0.264901962529956 1230 5285744
SGTC_3147 9097027 49.47 µM 0.62744848560778 0.259588578626123 no 913 0.265182646926048 1347 25236841
SGTC_1007 4101-0031 70 µM 0.626883907688324 0.259770700288496 no 914 0.265367668261721 1282 1146276
SGTC_440 fluspirilene 35.1 µM 0.621718550141993 0.261439998250767 no 915 0.26706347588487 1391 3396 An atypical antipsychotic.
SGTC_3068 9116768 49.47 µM 0.621562472458482 0.261490523758811 no 916 0.267114801854673 1284 41904888
SGTC_2603 homopterocarpin 100 µM 0.621454520465963 0.261525472938422 no 917 0.267150304658539 1312 101795 A weak amylase inhibitor.
SGTC_2689 tacrolimus 100 µM 0.621453593332582 0.261525773105853 no 918 0.267150609580638 1316 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1399 3562-5772 25 µM 0.618991185420305 0.262323622483501 no 919 0.267961082867272 1273 23847490
SGTC_2861 9024595 19.48 µM 0.617380245473233 0.262846259870526 no 920 0.268491974392417 1269 16482810
SGTC_3277 9138724 49.47 µM 0.615321323745896 0.263515010339401 no 921 0.269171268990397 1281 15943418
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.614884070426599 0.263657144619069 no 922 0.269315641741306 1281 140250 A respiratory chain inhibitor.
SGTC_328 k915-0120 63.5 µM 0.613688837546793 0.264045868440375 no 923 0.269710483008857 1328 6624543
SGTC_923 1900-2434 73.3 µM 0.613430318980858 0.264129984447249 no 924 0.269795921891734 1293 5910570
SGTC_61 0978-8327 98.565 µM 0.612462283554526 0.264445082166361 no 925 0.270115972310606 1342 6150059 YHR072W ERG7
SGTC_1458 k015-0034 6.33 µM 0.612440213572839 0.264452268225172 no 926 0.270123271268556 1271 3598957
SGTC_349 k015-0014 24 µM 0.608629120307898 0.265694661238577 no 927 0.271385149021336 1303 2196908
SGTC_2427 5545055 42.75 µM 0.608095268512029 0.265868929659174 no 928 0.271562145076327 1378 5372858
SGTC_3062 9077494 49.47 µM 0.604892313459384 0.266915704199762 no 929 0.272625275382173 1341 16459633
SGTC_443 clozapine 122 µM 0.604604160753452 0.267009978870989 no 930 0.272721020708724 1264 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_442 cape 100 µM 0.603684095272275 0.267311108420889 no 931 0.273026845152264 1375 5281787
SGTC_2905 7799065 20.05 µM 0.603123120237755 0.267494794793751 no 932 0.273213393399569 1308 1296806
SGTC_2304 7443016 91.4 µM 0.602510396439871 0.267695498549456 no 933 0.273417222458215 1321 939854
SGTC_941 3237-0776 460 µM 0.60024132364309 0.26843941615215 no 934 0.274172708597246 1391 760008
SGTC_2275 7947463 200 µM 0.5972622239408 0.269417692466864 no 935 0.275166160656863 1296 1225414
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.596999249654752 0.269504133692286 no 936 0.275253940786601 1341 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1837 st055472 66.5 µM 0.594649242652339 0.270277211661797 no 937 0.276038978405745 1395 676091
SGTC_3302 9125395 16.351 µM 0.59462855262787 0.270284022946102 no 938 0.276045894944274 1362 17599668
SGTC_985 1493-0307 8.71 µM 0.594222604225876 0.270417681034911 no 939 0.276181618025307 1318 3278274
SGTC_2967 9089538 49.85 µM 0.592713794328234 0.27091474448792 no 940 0.276686354078339 1397 728216
SGTC_1915 st067105 30.6 µM 0.59196275468186 0.271162337388727 no 941 0.276937764708126 1319 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_100 0086-0128 49.5915 µM 0.591650001731727 0.271265474943997 no 942 0.277042491780115 1286 93297
SGTC_2971 9092186 9.93 µM 0.590492860053692 0.271647239237615 no 943 0.277430135583287 1278 25236400
SGTC_116 0155-0182 31.788 µM 0.588814830993552 0.272201329534158 no 944 0.27799274788784 1335 771486
SGTC_2914 7968218 45.32 µM 0.588281326500193 0.272377611950572 no 945 0.278171738709999 1381 2977111
SGTC_2052 5265182 7.135 µM 0.588004351981521 0.272469153195086 no 946 0.278264685852989 1409 1239884
SGTC_3286 9117135 37.221 µM 0.585694903221553 0.273233029997053 no 947 0.27904027987935 1320 3438150
SGTC_1880 MG-132 525 µM 0.585439316184183 0.273317633515053 no 948 0.279126179554884 1334 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_438 sphingosine 6.67 µM 0.585296797208842 0.273364815276484 no 949 0.279174084020907 1222 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_279 1273-0055 2.93 µM 0.584345654913102 0.273679799878386 no 950 0.279493890860609 1398 2847562
SGTC_1718 roemerine 11.9335 µM 0.584086130489541 0.273765776333896 no 951 0.279581182804361 1314 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2194 5927483 104.545 µM 0.583144095940761 0.274077970113446 no 952 0.279898150572882 1370 760979
SGTC_1607 st000305 50.6 µM 0.582463715391962 0.274303560125941 no 953 0.280127187565437 1407 5457690
SGTC_1697 st025554 27.742 µM 0.582446599176491 0.274309236436714 no 954 0.280132950580286 1328 1269519
SGTC_3143 9086658 49.47 µM 0.58167742421362 0.274564380482183 no 955 0.280391990407105 1407 25236626
SGTC_2831 7999036 19.48 µM 0.581455116777857 0.274638144178647 no 956 0.280466879860509 1489 2988270
SGTC_1794 st048918 76.9 µM 0.5806464039801 0.274906565109119 no 957 0.280739395308059 1322 672303
SGTC_1062 mesoridazine 14.2 µM 0.579798716123712 0.275188061010803 no 958 0.281025181746024 1374 4078 A neuroleptic.
SGTC_1777 st045864 34.765 µM 0.579535318876577 0.27527555752916 no 959 0.281114011163877 1355 4691462
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.578287170443493 0.27569035935117 no 960 0.281535127356535 1366 97141
SGTC_359 0081-0058 15.9 µM 0.577502065102902 0.275951433661291 no 961 0.281800171994162 1510 3494159
SGTC_545 4218-0007 221 µM 0.577408940429376 0.275982408846406 no 962 0.281831618038803 1353 2840508
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.57536747609747 0.276661870637188 no 963 0.2825213977632 1348 2374 Ca(2+)-ATPase inhibitor.
SGTC_1438 4092-1045 4 µM 0.575058583048425 0.276764751053762 no 964 0.282625838682589 1351 1351342
SGTC_2842 9000675 19.48 µM 0.574808710979912 0.276847987557661 no 965 0.282710337384881 1318 2989072
SGTC_1546 5-methoxyflavanone 78.7 µM 0.570245499028144 0.27837022133957 no 966 0.284255600182677 1429 147795
SGTC_1408 3909-7976 48.8 µM 0.568203622220298 0.279052685964758 no 967 0.284948356094043 1406 24152374
SGTC_2063 5246145 200 µM 0.564632956273872 0.280248075806546 no 968 0.286161722177904 1426 711240
SGTC_3174 9107204 49.47 µM 0.562381118017585 0.28100322094327 no 969 0.286928190520776 1416 3938802
SGTC_3175 9106517 49.47 µM 0.562108761125136 0.281094621369957 no 970 0.287020959758007 1355 41468073
SGTC_2224 6650123 117.647 µM 0.561973167741022 0.281140130596008 no 971 0.287067150390979 1370 2908370
SGTC_1736 st036774 51 µM 0.560221263781195 0.281728442161908 no 972 0.287664262443802 1450 1272247
SGTC_1459 k035-0031 35.7 µM 0.55561385575566 0.283278494838157 no 973 0.289237428687611 1304 3877128 YMR208W ERG12
SGTC_2728 chlorpromazine 9.18 µM 0.555179550701584 0.283424817115674 no 974 0.289385927340856 1403 2726 A thorazine and dopamine antagonist.
SGTC_803 4488-1585 147 µM 0.554251194775892 0.28373771215171 no 975 0.289703473143882 1378 747204
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.553836473899968 0.283877543982856 no 976 0.289845381984285 1473 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.553427057441301 0.284015619665103 no 977 0.289985507739409 1300 4000243
SGTC_697 0508-1955 564 µM 0.553062378075896 0.284138634814602 no 978 0.290110348638667 1436 6243113
SGTC_2245 6637752 200 µM 0.553056860351772 0.284140496271757 no 979 0.290112237717791 1467 681890
SGTC_3021 9087658 49.47 µM 0.551731522495294 0.284587780557585 no 980 0.290566154751642 1390 25237042
SGTC_821 1114-0266 29.2 µM 0.54875233399333 0.28559444345488 no 981 0.291587712909875 1398 3123235
SGTC_911 3456-4043 236 µM 0.545223135008179 0.286789142266056 no 982 0.292800030923927 1512 914281
SGTC_678 1218-2179 85.9 µM 0.543224059714281 0.287466915330514 no 983 0.293487771493155 1445 6820081 YOR116C RPO31
SGTC_615 k087-0205 167 µM 0.542138015687102 0.287835448545097 no 984 0.293861715891239 1370 9642773
SGTC_2653 dihydrofissinolide 100 µM 0.538928116804628 0.288925983384996 no 985 0.294968227753443 1443 6857746
SGTC_2925 9010536 32.5 µM 0.537989998923633 0.289245067414337 no 986 0.295291976575986 1504 2994177
SGTC_619 1652-1634 108 µM 0.537739618429397 0.289330257859641 no 987 0.295378411683176 1416 5400454
SGTC_2430 5571206 200 µM 0.537462339453456 0.289424614106428 no 988 0.295474146131088 1469 1731771
SGTC_403 arphamenine a 50 µM 0.536826381008904 0.289641081242054 no 989 0.295693773568694 1437 5487158 An arginine aminopeptidase inhibitor.
SGTC_1997 st073024 93.8 µM 0.536645523535444 0.289702655271732 no 990 0.295756246165296 1401 686268
SGTC_1706 st031321 9.9705 µM 0.536024601374967 0.289914098743801 no 991 0.295970774008345 1486 6103185
SGTC_1406 3909-7906 11.9 µM 0.534878065166619 0.290304720370803 no 992 0.296367088491717 1448 X1406
SGTC_839 0122-0028 230 µM 0.534794853646038 0.290333079890577 no 993 0.296395861054566 1433 759448
SGTC_2453 5731132 22.18 µM 0.534442302324199 0.290453248150089 no 994 0.296517779111752 1539 1362040
SGTC_2373 9071805 200 µM 0.531632545663104 0.291411793942049 no 995 0.297490259534778 1518 10149009
SGTC_2208 7283366 200 µM 0.531436234775957 0.291478820335766 no 996 0.297558258781206 1497 898663
SGTC_1463 k081-0032 34.1 µM 0.531281843953849 0.291531539019514 no 997 0.297611742508518 1334 977755
SGTC_1830 st055982 50.3 µM 0.531217579449609 0.291553484251563 no 998 0.297634006169208 1450 455313 An antimicrobial agent.
SGTC_1892 st058411 7.36 µM 0.531042117983505 0.291613405271876 no 999 0.297694796543582 1503 3934738
SGTC_532 1548-0774 215 µM 0.529875285931553 0.292012030568184 no 1000 0.298099201165584 1541 5932993
SGTC_1498 4478-3555 97.6 µM 0.529769531713496 0.292048171958531 no 1001 0.298135866189661 1447 3437919
SGTC_2784 7567673 72.73 µM 0.528884848731617 0.292350592953503 no 1002 0.298442666528657 1437 3471247
SGTC_2205 7238770 200 µM 0.528278731557636 0.292557872736344 no 1003 0.298652945571709 1469 279867
SGTC_2117 5521686 200 µM 0.528153599546509 0.292600673849903 no 1004 0.298696365763285 1401 803312
SGTC_1345 1488-0192 31.4 µM 0.527046084827081 0.292979623448605 no 1005 0.299080792960005 1469 658348
SGTC_2627 acetyl isogambogic acid 100 µM 0.526986066016844 0.293000166115852 no 1006 0.299101632382641 1377 6857789 A caspase activator and apoptosis inducer.
SGTC_791 1348-1292 225 µM 0.526286222643072 0.293239751158403 no 1007 0.29934467703865 1446 5437054
SGTC_675 1309-0189 238 µM 0.525680683219722 0.293447125353413 no 1008 0.299555043660944 1404 4246530
SGTC_1437 4092-1038 11.6 µM 0.525545395576214 0.293493465502478 no 1009 0.299602052240887 1408 3977136
SGTC_659 k018-0002 107 µM 0.52551349494721 0.29350439293584 no 1010 0.299613137282482 1477 6797879 YHR007C ERG11
SGTC_252 miconazole 1.30953 nM 0.525358282542947 0.293557563015057 no 1011 0.299667074167036 1416 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1600 coumarin 106 71.1 µM 0.524497016444401 0.293852682212419 no 1012 0.299966447212681 1486 100336 A hepatotoxic, DNA x-linker.
SGTC_1994 st072947 40.9 µM 0.523509443958101 0.294191250032733 no 1013 0.300309890378765 1474 5286565 YDL195W SEC31
SGTC_1824 st053723 68.6 µM 0.522794917111801 0.294436322389398 no 1014 0.300558488574055 1404 675225
SGTC_2624 nerol 100 µM 0.522284838558522 0.294611329574014 no 1015 0.30073601193955 1507 637566 A natural product oil.
SGTC_1019 4262-0212 3.4 µM 0.521379883054791 0.294921936481694 no 1016 0.301051081269887 1483 4677213
SGTC_1968 st069590 43.6 µM 0.521320230409839 0.294942416295614 no 1017 0.301071855162066 1464 6384066
SGTC_2634 4'-methoxyflavone 100 µM 0.518969377576011 0.29575002712845 no 1018 0.30189104794109 1473 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1243 0416-0003 5.65 µM 0.518823017526443 0.29580034116981 no 1019 0.301942082575742 1442 2141977
SGTC_1283 0922-0125 16.4 µM 0.514334804266782 0.29734515487353 no 1020 0.303508966132092 1547 3360884
SGTC_3282 9108498 15.4605 µM 0.51378524437702 0.297534562810766 no 1021 0.303701072719491 1434 16459645
SGTC_408 cantharidin 100 µM 0.511802488966421 0.298218384531692 no 1022 0.304394624116165 1465 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2654 protoveratrine a 100 µM 0.51123100010514 0.298415615011379 no 1023 0.304594656997458 1459 5702278 A heart drug and vasodilator.
SGTC_224 benfluorex 43.875 µM 0.50902403966929 0.299177831065268 no 1024 0.305367686916409 1541 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2286 7945697 125 µM 0.507429257516409 0.299729168922367 no 1025 0.305926830696558 1401 1245733
SGTC_2469 5655019 90.81 µM 0.507416567152305 0.299733557998609 no 1026 0.305931281859664 1587 2788239
SGTC_1714 st033236 13.627 µM 0.501596561401807 0.301749518906897 no 1027 0.307975669347688 1576 2916566
SGTC_3355 9151058 44.0485 µM 0.501253366147301 0.301868586596711 no 1028 0.308096410317587 1464 17015728
SGTC_800 3448-7362 155 µM 0.499656893846136 0.30242274181558 no 1029 0.308658344865828 1540 15991913
SGTC_946 3434-1334 87.4 µM 0.49789685198097 0.303034202176451 no 1030 0.309278373127369 1553 4047976
SGTC_2089 5281248 129.67 µM 0.495476602172312 0.303875928976198 no 1031 0.310131867092138 1472 2737878
SGTC_1503 4585-0012 61.3 µM 0.495437516041034 0.303889531102951 no 1032 0.310145659114335 1550 2922052
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.495431464477101 0.303891637095175 no 1033 0.310147794506983 1477 17037758
SGTC_1713 st033146 12.748 µM 0.49201636567656 0.30508115519446 no 1034 0.311353887098513 1597 674619
SGTC_2616 abietic acid 100 µM 0.490908811086508 0.305467372642603 no 1035 0.31174547244176 1531 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_708 3448-5400 146 µM 0.489220883763147 0.30605638946716 no 1036 0.312342662977968 1479 3462195
SGTC_1943 st076331 65.2 µM 0.488910907799214 0.30616461284168 no 1037 0.312452386470548 1528 24208415
SGTC_1307 1187-1599 12.2 µM 0.488800161620146 0.306203282281423 no 1038 0.312491591792722 1482 1538471
SGTC_2937 9044753 11.33 µM 0.488507513444765 0.306305477154358 no 1039 0.312595202564438 1440 6465530 YGL099W LSG1
SGTC_1154 4088-0362 150 µM 0.488243779909828 0.306397587735397 no 1040 0.312688588928032 1466 6618304
SGTC_3351 9150312 21.596 µM 0.485156856432119 0.307476623460712 no 1041 0.31378254168641 1490 4904905
SGTC_2126 5251174 33.877 µM 0.484299750393128 0.307776521625038 no 1042 0.314086576533382 1668 790722
SGTC_1899 st063254 59.6 µM 0.483982837943395 0.307887440636617 no 1043 0.314199024502638 1422 3093813
SGTC_2586 curcumin 80 µM 0.483712356916465 0.30798212258756 no 1044 0.314295011157579 1578 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3194 9111903 49.47 µM 0.483238526921374 0.308148017704795 no 1045 0.314463191320877 1564 17087251
SGTC_2529 gangaleoidin 93.61 µM 0.482427776275347 0.308431964798511 no 1046 0.3147510466607 1535 4565183
SGTC_2240 6690706 185.951 µM 0.481656488434468 0.308702197340925 no 1047 0.315024995337379 1427 805876
SGTC_420 mitomycin C 81.9 mM 0.47714100854996 0.310286340465542 no 1048 0.316630857363593 1480 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3013 9080133 71.4286 µM 0.476782196245901 0.310412372402541 no 1049 0.316758612406028 1588 17050193
SGTC_233 rapamycin 362 pM 0.475656989349266 0.31080774287164 no 1050 0.317159383762598 1539 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3305 9127027 53.8275 µM 0.472411314870868 0.311949417499316 no 1051 0.318316614803556 1522 41905295
SGTC_2424 5537928 59.2 µM 0.471505385605163 0.312268403937199 no 1052 0.318639937319963 1504 5382802
SGTC_819 1013-0258 27.7 µM 0.471300587606595 0.312340534805694 no 1053 0.318713048054118 1508 5753198
SGTC_372 0155-0182 15.9 µM 0.471065920826166 0.31242319444887 no 1054 0.318796830305504 1560 771486
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.46947055953917 0.312985398751695 no 1055 0.319366661847693 1700 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1241 0364-0022 50.8 µM 0.469152789478066 0.313097432729378 no 1056 0.319480214063529 1593 4563895
SGTC_1667 st014849 34.6 µM 0.466982106560827 0.313863196433562 no 1057 0.320256340042438 1544 5348460
SGTC_1379 2144-0755 36.5 µM 0.466902924810579 0.313891145001717 no 1058 0.320284666312823 1587 5392327
SGTC_2139 5578692 56.4705 µM 0.465303063092999 0.314456072422925 no 1059 0.320857220774695 1606 650991 YMR113W FOL3
SGTC_2545 solidagenone 89.61 µM 0.463615440303268 0.315052460391988 no 1060 0.321461645029432 1459 6708572 An anti ulcer agent
SGTC_1849 st056239 19.2 µM 0.462983612230378 0.315275865936814 no 1061 0.321688056848376 1431 5393181
SGTC_65 0798-0905 34.986 µM 0.462780897126227 0.315347557474494 no 1062 0.321760712635185 1730 3602145
SGTC_892 0929-0076 29 µM 0.45911268900646 0.316646042597723 no 1063 0.323076622507312 1530 5751038
SGTC_3086 9117350 49.47 µM 0.458432327706136 0.316887128497617 no 1064 0.323320935296059 1480 2679265
SGTC_2899 9053889 58.44 µM 0.458214148761851 0.316964456639932 no 1065 0.32339929790927 1572 6470052
SGTC_2234 tolnaftate 200 µM 0.457108968104643 0.317356283419264 no 1066 0.323796362302379 1554 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1588 farnesol 29.9 µM 0.4558188240028 0.317813945516889 no 1067 0.324260133334727 1515 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3319 9138450 16.7555 µM 0.454799355119522 0.318175786053154 no 1068 0.324626797121908 1522 2029690
SGTC_269 exalamide 29 µM 0.454468812562442 0.318293142950137 no 1069 0.324745717098922 1584 3316 A derivative of salicylamide.
SGTC_2347 9049783 174.81 µM 0.453502479741738 0.318636337448704 no 1070 0.325093479072652 1613 6467988 YPL169C MEX67
SGTC_535 2293-4129 48.2 µM 0.453466680061823 0.31864905474825 no 1071 0.325106365521561 1649 396118 YIL048W NEO1
SGTC_935 2996-0153 430 µM 0.452893522191055 0.31885268956658 no 1072 0.325312707843964 1653 23738523
SGTC_2416 tofa 880 nM 0.45198452369393 0.319175755920709 no 1073 0.325640065834883 1454 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.450791176699343 0.319600090857034 no 1074 0.326070030556484 1595 77254
SGTC_2053 5265679 138 µM 0.449019598620351 0.320230471100963 no 1075 0.326708759344244 1493 764595
SGTC_2333 9017922 200 µM 0.446592115004715 0.321095084993792 no 1076 0.327584794899643 1696 3163164
SGTC_3353 9151644 39.2805 µM 0.446539788885786 0.321113733060215 no 1077 0.327603688939943 1554 4909158
SGTC_2508 celastrol 40.54 µM 0.44483915455047 0.321720053228389 no 1078 0.328217998159624 1499 122724 Celastrol is a natural product and antioxidant.
SGTC_1333 1482-0047 286 µM 0.44446797913012 0.321852450093961 no 1079 0.32835213733014 1613 3811116
SGTC_1662 st014054 52 µM 0.444151914947338 0.321965206822694 no 1080 0.32846637728483 1527 2838777
SGTC_1402 3909-7673 35.9 µM 0.443769976323802 0.322101486305201 no 1081 0.328604448654862 1528 5328014
SGTC_3275 9138069 49.47 µM 0.441267084277082 0.322995134324034 no 1082 0.329509826253735 1606 17617007
SGTC_2985 9022375 71.43 µM 0.441058340627679 0.323069711721859 no 1083 0.329585380896307 1562 4939335
SGTC_1025 k007-0731 70 µM 0.439703571226055 0.323553900069231 no 1084 0.330075907859098 1534 6256118
SGTC_2108 5365811 200 µM 0.437425944241391 0.324368586815484 no 1085 0.330901236081541 1627 780283
SGTC_2911 7942208 15.64 µM 0.437025961242569 0.324511744112318 no 1086 0.331046260225379 1538 1243384
SGTC_644 1498-1197 63.3 µM 0.435501235897881 0.325057693920545 no 1087 0.331599321055463 1623 6741615
SGTC_2760 etidronate 98.04 µM 0.435183906080371 0.32517136570752 no 1088 0.331714471737943 1542 3305 A chelator and antioxidant.
SGTC_3323 9138564 53.9225 µM 0.43480772679394 0.325306139239647 no 1089 0.331850997951542 1702 43912313 YNL103W MET4
SGTC_304 1310-0298 97 µM 0.434040058543164 0.325581242177929 no 1090 0.332129675970732 1531 1550234
SGTC_3258 9138477 49.47 µM 0.433684890483386 0.325708552990477 no 1091 0.332258640090509 1608 4970355
SGTC_3148 9097893 49.47 µM 0.433036105344018 0.325941164004668 no 1092 0.332494269998986 1434 17174100
SGTC_471 1-acyl-paf 4 µM 0.432789207862891 0.326029702754152 no 1093 0.332583957191264 1514 16759367
SGTC_1201 1889-3372 45.9 µM 0.43260874472214 0.3260944240014 no 1094 0.332649517719702 1576 5392199
SGTC_1643 st009866 20.2 µM 0.431813364604378 0.326379741297908 no 1095 0.332938532660028 1640 3156273 YOR207C RET1
SGTC_1501 4491-0275 38.4 µM 0.430986307377885 0.326676529524889 no 1096 0.333239163306965 1648 5104718
SGTC_3276 9139060 49.47 µM 0.4307728352181 0.326753151506082 no 1097 0.333316776644495 1610 4870619
SGTC_1073 triclabendazole 3.09 µM 0.430446331287486 0.326870358336498 no 1098 0.333435499418354 1608 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.42772578248681 0.32784763130789 no 1099 0.334425388300892 1627 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_695 3505-6186 243 µM 0.427292698964023 0.328003312217688 no 1100 0.334583074974805 1636 1819379
SGTC_2716 st080858 38.6235 µM 0.426013405807358 0.328463355295676 no 1101 0.335049038789616 1640 5296050
SGTC_317 4495-0002 170 µM 0.42291842478873 0.329577407925653 no 1102 0.33617738976849 1569 15991618
SGTC_1139 k015-0024 46.9 µM 0.422639836854964 0.329677761353829 no 1103 0.336279028443024 1658 2766652
SGTC_586 0957-0265 8.15 µM 0.421852729731915 0.32996136070118 no 1104 0.336566257452084 1594 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3025 9087895 49.47 µM 0.421366640462647 0.330136550375276 no 1105 0.336743687490966 1675 17173641
SGTC_2791 5663188 71.43 µM 0.420171906332413 0.330567298408692 no 1106 0.337179938148861 1673 54690634
SGTC_3133 9127736 49.47 µM 0.418584097113431 0.331140112702045 no 1107 0.337760056955426 1722 27243420
SGTC_3203 9113543 49.47 µM 0.417166105022373 0.331651998476694 no 1108 0.33827845777559 1660 17018012
SGTC_1329 1447-1697 50.6 µM 0.414287679638096 0.332692057506648 no 1109 0.339331717821448 1608 2840515
SGTC_3003 9075612 71.4286 µM 0.412876534938824 0.333202416628925 no 1110 0.339848536872739 1614 6501993
SGTC_2204 7233102 200 µM 0.41268799629806 0.333270627540688 no 1111 0.3399176102821 1639 2172480
SGTC_928 2764-0428 58.7 µM 0.411979692482829 0.333526932222799 no 1112 0.340177153950913 1650 662578
SGTC_177 1327-0068 8.361 µM 0.410673519947983 0.333999783635624 no 1113 0.340655973130133 1575 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2235 salicylic acid 500 µM 0.405889158710492 0.335734031333124 no 1114 0.34241202207773 1647 338 A COX inhibitor and kinase inhibitor.
SGTC_897 1000-0139 31.4 µM 0.404434816557013 0.336261901308134 no 1115 0.342946500962045 1741 6151020
SGTC_3048 9093155 49.47 µM 0.404328039883813 0.336300669851842 no 1116 0.342985754390264 1653 25236002
SGTC_2172 5754775 163.918 µM 0.402497041106225 0.336965740644987 no 1117 0.343659132761847 1575 2263357
SGTC_1327 1436-0082 2.18 µM 0.401705729122159 0.33725332560909 no 1118 0.343950303839531 1629 15992205
SGTC_1210 3013-0140 750 nM 0.401187842902638 0.337441591491438 no 1119 0.34414091532732 1755 905973
SGTC_205 1486-1330 71.903 µM 0.400920624491999 0.337538748653577 no 1120 0.344239282344489 1658 4118834
SGTC_2144 5628481 200 µM 0.400454907635429 0.337708103169999 no 1121 0.344410744737839 1640 2818399
SGTC_369 0957-0393 4.5 µM 0.399957171083387 0.33788913774805 no 1122 0.344594031135907 1567 6997992
SGTC_1232 0279-0259 161 µM 0.399490431011742 0.338058932496793 no 1123 0.344765936550699 1601 1560000
SGTC_725 1497-0963 19 µM 0.399428748304145 0.338081374432468 no 1124 0.344788657357652 1764 3549977
SGTC_2588 indole-3-carbinol 100 µM 0.39570385351686 0.339437661829763 no 1125 0.34616175618682 1767 3712 Induces cell cycle arrest.
SGTC_3335 9143315 29.6265 µM 0.394074504114317 0.340031586965878 no 1126 0.346763016946174 1600 4899691
SGTC_448 monastrol 171 µM 0.393784686661631 0.340137271931208 no 1127 0.346870005563862 1657 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_83 0170-0301 39.027 µM 0.392400301181747 0.340642275757431 no 1128 0.347381231771279 1668 3089716
SGTC_1343 1487-0095 224 µM 0.391837687769499 0.340847590729797 no 1129 0.347589073223115 1740 4560101 YGL055W OLE1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.391483432837069 0.340976893467496 no 1130 0.347719966101598 1602 61125 An anti-inflammatory.
SGTC_2065 5221596 34.26 µM 0.390093901638685 0.341484251348071 no 1131 0.348233556064371 1664 788581
SGTC_315 k915-0449 187 µM 0.386519211308299 0.342790788918898 no 1132 0.349556088717981 1701 20970215 YNL149C PGA2
SGTC_3271 9137798 49.47 µM 0.383788112325687 0.343790266252448 no 1133 0.350567749800858 1758 6498326
SGTC_3117 9124945 49.47 µM 0.383358495174906 0.343947589274788 no 1134 0.35072698648671 1562 17592065
SGTC_2315 7733312 200 µM 0.38237014419194 0.344309619560277 no 1135 0.351093416216219 1613 726316
SGTC_768 0384-0033 77.3 µM 0.381645871595225 0.344575009277181 no 1136 0.351362027213281 1620 3965305 YMR134W ERG29
SGTC_1148 3909-7663 27.7 µM 0.381569473207928 0.344603007822794 no 1137 0.351390365416915 1733 4084526
SGTC_1362 1611-0397 101 µM 0.381514216771789 0.344623258778803 no 1138 0.351410862020667 1632 27816
SGTC_3205 9113483 49.47 µM 0.381352992830075 0.344682348358192 no 1139 0.351470668261022 1764 17018033
SGTC_1960 st011366 51.8 µM 0.380318286657857 0.345061664766639 no 1140 0.351854581393781 1638 3972846
SGTC_1124 fisetin 1.16336 µM 0.379965938941661 0.345190868663956 no 1141 0.351985349551586 1623 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2084 5306078 60.6385 µM 0.379004898143003 0.345543368545133 no 1142 0.352342113268353 1704 679340
SGTC_1042 0350-0096 82 µM 0.377991907667286 0.345915068077547 no 1143 0.352718302770618 1611 3122515
SGTC_1204 4049-0315 18.3 µM 0.375819516652887 0.346712690272764 no 1144 0.353525538741075 1768 588402
SGTC_1374 2889-5571 141 µM 0.375781948119411 0.346726490049343 no 1145 0.353539504592917 1648 2853281
SGTC_3240 9133527 49.47 µM 0.375604812219947 0.346791558832562 no 1146 0.353605356338694 1646 17617455
SGTC_159 3970-0959 50 µM 0.374826931326969 0.347077357679358 no 1147 0.353894591883048 1713 6615653
SGTC_468 gf-109203x 121 µM 0.374815352509222 0.347081612475035 no 1148 0.353898897814136 1747 2396 A protein kinase C inhibitor.
SGTC_1809 st050081 57.6 µM 0.374721024300522 0.347116275389593 no 1149 0.353933977287386 1735 5036894
SGTC_618 k072-0232 33.2 µM 0.374154111303856 0.347324626612032 no 1150 0.354144831204155 1685 5872756 YGL099W LSG1
SGTC_853 0419-0306 21 µM 0.373670097150727 0.347502547465553 no 1151 0.3543248876655 1606 762713
SGTC_1636 st007707 68.9 µM 0.372163530438949 0.348056567750776 no 1152 0.354885548724812 1781 403051
SGTC_3125 9127534 49.47 µM 0.371641045248865 0.348248780712712 no 1153 0.355080062394204 1654 1639235
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.370587075090784 0.348636636089778 no 1154 0.35547255512616 1711 7104
SGTC_337 1315-0038 354 µM 0.370458564341604 0.348683938190889 no 1155 0.35552042232273 1663 1626437
SGTC_1259 0671-0132 43 µM 0.37006295387668 0.34882956883867 no 1156 0.355667792111662 1665 X1259
SGTC_331 k048-0133 24.5 µM 0.369286058829835 0.349115621346832 no 1157 0.355957257893089 1642 6813582
SGTC_2798 7813637 45.45 µM 0.366847171885052 0.350014175230778 no 1158 0.356866509435208 1730 956368
SGTC_854 0422-0053 192 µM 0.363383379807767 0.351291776350945 no 1159 0.358159257733854 1637 3596728
SGTC_1590 st077108 57.8 µM 0.363351471487176 0.351303553405235 no 1160 0.35817117407106 1814 5489485
SGTC_3344 9148862 3.898 µM 0.362665006616381 0.35155695554849 no 1161 0.358427571580488 1763 4905352
SGTC_638 3970-0837 4.09 µM 0.361529714784714 0.351976182751756 no 1162 0.358851747887869 1651 4118451 YLR208W SEC13
SGTC_396 dithiazanine 1.25 µM 0.359757166629207 0.352631088234093 no 1163 0.35951436872269 1653 10578 An antihelmenthic.
SGTC_1492 4158-0558 28.5 µM 0.359523593797392 0.352717419296381 no 1164 0.359601715383252 1793 3967268
SGTC_2698 st077697 67.5 µM 0.35944043528514 0.352748157419362 no 1165 0.359632815027489 1619 3154499
SGTC_1323 1348-1351 11.2 µM 0.358169194188141 0.353218169531813 no 1166 0.360108349751002 1668 6989654
SGTC_293 4049-0273 38.5 µM 0.358057287688816 0.3532595551189 no 1167 0.360150221134193 1694 1380311
SGTC_69 0096-0274 206.684 µM 0.356408997967548 0.353869331210661 no 1168 0.360767145915203 1774 6741392
SGTC_406 estrone 100 µM 0.355822545058195 0.35408637691245 no 1169 0.360986732058265 1813 5870 A steroid.
SGTC_1767 st044992 70.3 µM 0.355140653136565 0.354338804124961 no 1170 0.361242111140642 1623 9600693
SGTC_1973 st070275 50.2 µM 0.35476087990457 0.354479418822101 no 1171 0.361384368919353 1740 17118334
SGTC_3219 9131112 49.47 µM 0.354462709721672 0.354589833106294 no 1172 0.361496072762125 1705 17612988 YMR079W SEC14
SGTC_3213 9129884 49.47 µM 0.353793140828095 0.354837823173548 no 1173 0.361746957148156 1567 17190742
SGTC_194 1486-1323 56.904 µM 0.353668777616953 0.354883890694806 no 1174 0.361793562019767 1664 5178754
SGTC_2805 7950783 58.44 µM 0.351569248282397 0.355661933354352 no 1175 0.362580665474246 1722 1178958 YDL195W SEC31
SGTC_2688 kanamycin b 96.69 µM 0.351250912776699 0.355779954601197 no 1176 0.362700058742157 1694 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1895 st058434 18.3 µM 0.350722252291755 0.35597598328865 no 1177 0.362898364899649 1827 5393175
SGTC_1865 st057639 52.2 µM 0.349916872387867 0.356274693442599 no 1178 0.363200542112137 1709 688818
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.345226929952603 0.358015909804727 no 1179 0.36496188734904 1746 66535 A nucleotide analog.
SGTC_459 nigericin 15.3 µM 0.343777410413581 0.35855466724404 no 1180 0.365506844922688 1735 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_540 1187-0821 17.3 µM 0.342215507251718 0.359135510652228 no 1181 0.366094357952368 1651 847520
SGTC_1427 4048-4900 550 nM 0.338094135425771 0.360669734788851 no 1182 0.367646124926741 1838 24132586
SGTC_3257 9139206 32.98 µM 0.338086638928256 0.360672527492259 no 1183 0.36764894946478 1794 4910041
SGTC_2462 5162487 171.77 µM 0.337748636197025 0.360798452864479 no 1184 0.367776309917114 1841 2259986
SGTC_3306 9127676 59.7925 µM 0.336919054437159 0.361107583531046 no 1185 0.368088960447301 1690 41905287
SGTC_2386 9075165 157.42 µM 0.336563443702724 0.361240124103837 no 1186 0.368223008832416 1737 16452277
SGTC_432 NS 1619 61.3 µM 0.335189026800253 0.361752542973675 no 1187 0.368741249541403 1740 4552 A K+/calcium channel activator.
SGTC_511 blebbistatin 171 µM 0.334169419622464 0.362132839700816 no 1188 0.36912585923969 1815 3476986 A myosin inhibitor.
SGTC_730 1436-0052 41.2 µM 0.33356719062707 0.362357525198884 no 1189 0.369353089801949 1744 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2677 mitomycin C 100 µM 0.332990659040823 0.362572667689267 no 1190 0.369570667095815 1739 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2379 9035213 200 µM 0.330656978219202 0.363443962828454 no 1191 0.370451801165542 1873 646551
SGTC_2909 7941780 10.49 µM 0.329663330985053 0.363815162425508 no 1192 0.370827181904483 1875 1243215
SGTC_106 0092-0003 11.579 µM 0.328582029856915 0.36421925239593 no 1193 0.371235816316122 1858 1072148
SGTC_3016 9080866 49.47 µM 0.327840539425836 0.364496439976549 no 1194 0.371516116854629 1691 17066299
SGTC_2011 4012611 177 µM 0.326644543501277 0.364943682315985 no 1195 0.371968374531988 1675 2049887
SGTC_556 4058-0063 51.5 µM 0.325403995009817 0.365407779293242 no 1196 0.372437666163148 1744 6615692
SGTC_246 cycloheximide 667 µM 0.32490812897666 0.365593341076018 no 1197 0.372625302182905 1713 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.324801099951306 0.365633397347355 no 1198 0.372665806002018 1773 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2366 9070441 60.58 µM 0.323907745800231 0.365967797754207 no 1199 0.373003939786494 1678 6837235
SGTC_1752 st044819 83.042 µM 0.323124745806319 0.36626097414625 no 1200 0.373300385097088 1694 441209 YML126C ERG13
SGTC_2930 9013230 14.89 µM 0.323017880105982 0.366300993616465 no 1201 0.373340850478913 1842 2995857
SGTC_175 3793-3120 23.7 µM 0.322097575589428 0.366645692860281 no 1202 0.373689387447177 1725 5322297
SGTC_1787 fluconazole 80 µM 0.321555560510206 0.366848754486232 no 1203 0.373894707317965 1744 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3140 9094243 49.47 µM 0.32054560401434 0.367227226003699 no 1204 0.374277382762258 1905 19291112
SGTC_3222 9128301 49.47 µM 0.320002132750127 0.367430940078381 no 1205 0.374483356899553 1721 4911358
SGTC_1036 k216-0215 33.5 µM 0.31962493020218 0.367572352140335 no 1206 0.374626336707861 1695 622330
SGTC_2957 9076800 11.52 µM 0.317422221953317 0.368398498667018 no 1207 0.375461623855694 1692 16459615
SGTC_3325 9138760 55.175 µM 0.317239127131096 0.368467197565891 no 1208 0.375531081439402 1710 43844959
SGTC_2851 9015922 71.43 µM 0.317186055708789 0.368487111248683 no 1209 0.375551215000916 1834 2996893
SGTC_517 1365-0151 113 µM 0.317077490085054 0.368527848799982 no 1210 0.375592402302829 1771 768657
SGTC_1114 scopoletin 1.73284 µM 0.316938681517564 0.368579936695127 no 1211 0.375645065147619 1863 5280460 A coumarin with genotoxic properties.
SGTC_1791 st048313 56.1 µM 0.316806761812694 0.368629441783608 no 1212 0.375695116561079 1871 1204976
SGTC_3162 9099653 49.47 µM 0.315974792889245 0.368941702322209 no 1213 0.376010820530016 1836 25237511
SGTC_2359 9039622 200 µM 0.315686984597305 0.369049744747 no 1214 0.376120053341981 1822 6463596
SGTC_1670 st016595 4.04 µM 0.315204027654323 0.369231068673415 no 1215 0.376303373849677 1823 597879
SGTC_1487 3970-0795 2.82 µM 0.315058592403154 0.369285677361055 no 1216 0.376358583544744 1790 3765103
SGTC_762 1165-0429 115 µM 0.312971874015637 0.370069497785703 no 1217 0.377151015373361 1863 5967793
SGTC_513 4245-1575 41.7 µM 0.31246627249666 0.370259494977128 no 1218 0.377343095708159 1840 719745
SGTC_3099 9120367 49.47 µM 0.311929578511544 0.37046121087387 no 1219 0.377547021417084 1747 24824940
SGTC_867 0518-0118 155 µM 0.311753374449832 0.370527444764129 no 1220 0.377613980496468 1883 6848158
SGTC_74 000s-0487 160.283 µM 0.310466920232948 0.371011130206549 no 1221 0.378102955654381 1875 677548
SGTC_2895 9054447 58.44 µM 0.30998248670285 0.371193322055012 no 1222 0.378287137213192 1762 2697450
SGTC_2850 9015429 58.44 µM 0.308695110671985 0.371677634817592 no 1223 0.378776731714113 1715 6457570
SGTC_3294 9122953 26.2835 µM 0.30866561138298 0.371688734877655 no 1224 0.378787952700905 1711 16459826
SGTC_140 0062-0056 502.533 µM 0.30762579940331 0.372080065802279 no 1225 0.37918354325623 1700 3758964
SGTC_2666 tannic acid 100 µM 0.307003405542081 0.372314365604083 no 1226 0.379420390035119 1787 16134267 A thiamine antagonist.
SGTC_2563 tomatine 8.54 µM 0.306717529529428 0.372421999308686 no 1227 0.379529192934749 2018 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1739 st037196 92.5 µM 0.30624076347776 0.372601526203419 no 1228 0.379710668793904 1903 612214
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.305598681061115 0.372843346933542 no 1229 0.379955112412437 1799 165521
SGTC_696 1560-0013 611 µM 0.304934111120065 0.373093689684037 no 1230 0.380208167648708 1830 1650269
SGTC_547 1120-0019 610 nM 0.30471362152645 0.373176759711245 no 1231 0.380292137109396 1763 3676939
SGTC_1319 1306-0155 43.7 µM 0.303877171750146 0.373491947914001 no 1232 0.380610735094895 1801 3122360
SGTC_387 norethindrone acetate 66.7 µM 0.303111160795438 0.373780667859973 no 1233 0.380902574468623 1737 541197
SGTC_2023 5144124 124 µM 0.302867376668439 0.373872568280807 no 1234 0.380995467007058 1760 2830192
SGTC_808 0711-0032 135 µM 0.302429489346817 0.374037658677633 no 1235 0.381162338671943 1897 4252555
SGTC_1898 st060199 18.6 µM 0.30056213892514 0.374741938142307 no 1236 0.381874202962469 1747 688866
SGTC_1220 1838-0075 193 µM 0.299381967037386 0.375187260907721 no 1237 0.382324309890389 1815 5529645
SGTC_1801 st050089 28.441 µM 0.29884434867414 0.375390179526753 no 1238 0.38252940545958 1789 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_818 4072-2707 53.5 µM 0.297350843996726 0.375954068569818 no 1239 0.383099334044372 1718 882871
SGTC_1176 0848-0131 83.3 µM 0.2973300635902 0.375961916311634 no 1240 0.383107265736079 1939 6769040
SGTC_2915 7971052 15.16 µM 0.296015160711047 0.376458594923826 no 1241 0.383609251704236 1864 5741558
SGTC_3337 9144342 33.5465 µM 0.295988278993981 0.376468751098993 no 1242 0.383619516286457 1861 17682949
SGTC_231 b-estradiol 524 µM 0.295390391177516 0.376694661044778 no 1243 0.38384783636557 1745 450 A steroid.
SGTC_2837 9008476 45.46 µM 0.294502743719771 0.377030133589977 no 1244 0.384186883573839 1841 2992805
SGTC_44 0929-0055 61.211 µM 0.294473581945291 0.377041156405496 no 1245 0.384198023755999 1740 1379590
SGTC_510 ag-490 170 µM 0.294222856344018 0.377135931934104 no 1246 0.384293808186074 1884 5328779
SGTC_2137 5261020 140 µM 0.294085752846359 0.377187760871316 no 1247 0.384346188675699 1798 763655
SGTC_2673 kobusone 100 µM 0.293164996654087 0.377535889613041 no 1248 0.384698018915058 1834 6710676 An epoxy ketone and protein crosslinker.
SGTC_868 0527-0199 213 µM 0.292611304857132 0.377745282899626 no 1249 0.384909635892294 1795 2849450
SGTC_1529 apigenin 74 µM 0.292115539568262 0.377932800227092 no 1250 0.385099142876329 1909 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1829 berberine 14.4 µM 0.289801533385022 0.378808425366597 no 1251 0.385984037357381 1911 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1047 2043-3044 82 µM 0.289654003828499 0.378864272035167 no 1252 0.386040474015551 1729 669592
SGTC_913 3487-1245 167 µM 0.288182151428386 0.379421573630485 no 1253 0.386603655302996 1711 4016153
SGTC_1854 st056233 32.9 µM 0.287406837981466 0.379715238859673 no 1254 0.386900413009684 1934 5393174
SGTC_1310 1188-0297 994 nM 0.286693679051658 0.379985423116001 no 1255 0.387173438952807 1844 1588352
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.286598657716334 0.380021426907193 no 1256 0.387209821162201 1871 688761
SGTC_2228 7354201 200 µM 0.284124727983782 0.380959169377672 no 1257 0.388157398668885 1891 753451
SGTC_1084 voriconazole 435 nM 0.28358144484855 0.381165194597101 no 1258 0.388365579228846 1938 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_968 1309-0633 340 µM 0.283277922339286 0.381280311850396 no 1259 0.388481899930266 1923 3761976
SGTC_1134 3477-0009 42.5 µM 0.283020863830739 0.381377814877162 no 1260 0.38858042178446 1964 3973534
SGTC_1675 st018485 24.5 µM 0.282970113302321 0.381397065587772 no 1261 0.388599873597351 1790 3323024
SGTC_416 estradiol valerate 100 µM 0.281538423880822 0.381940255320673 no 1262 0.389148730683907 1826 13791 A steroid.
SGTC_2476 5806916 10.51 µM 0.27791534364923 0.383315905539009 no 1263 0.390538672593534 1860 2870194
SGTC_2997 9067075 71.4286 µM 0.27770193398253 0.383396981315263 no 1264 0.390620587934073 1870 27209819
SGTC_2928 9011484 9.79 µM 0.277347145264624 0.383531779249552 no 1265 0.390756781067677 1799 2994751
SGTC_3206 9114350 49.47 µM 0.277340270681911 0.383534391308275 no 1266 0.390759420153679 1876 17087243
SGTC_2295 7971645 200 µM 0.275657150742907 0.384174066686156 no 1267 0.391405704806601 1860 2978226 YKL099C UTP11
SGTC_481 bay k-8644 50 µM 0.275479011178666 0.384241787725331 no 1268 0.39147412444495 1784 2303 A calcium channel antagonist.
SGTC_626 0214-0009 33 µM 0.274720074797989 0.384530342435102 no 1269 0.391765653454579 1900 3437874
SGTC_1786 berberine 21.6 µM 0.274630684170813 0.384564333802956 no 1270 0.391799994936871 1761 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_727 3032-0951 202 µM 0.273141024498647 0.38513091703161 no 1271 0.392372406137643 1842 3652836
SGTC_2876 9059903 25.97 µM 0.272792675955797 0.385263444770186 no 1272 0.392506294930309 1846 6916095
SGTC_2449 5812982 45.77 µM 0.272772593002864 0.385271085653902 no 1273 0.392514014260724 1832 776185
SGTC_10 0279-0212 42.575 µM 0.27207950379546 0.385534809906875 no 1274 0.392780444432497 1808 39851 YBR002C RER2
SGTC_157 1348-1695 65.819 µM 0.270349085042477 0.386193474554039 no 1275 0.393445853151173 1804 5380510
SGTC_2663 amphotericin b 100 µM 0.269537497446873 0.386502509500331 no 1276 0.393758045367182 1849 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1552 6-methylflavone 10.6 µM 0.269363987065621 0.386568587836965 no 1277 0.393824798220738 1946 689013
SGTC_1106 tegaserod maleate 11.7 µM 0.268250481070659 0.386992724958626 no 1278 0.394253260037458 1858 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2474 5321570 43.32 µM 0.267630952031506 0.387228763539092 no 1279 0.394491701755883 1925 2841384
SGTC_2859 9028643 45.46 µM 0.267613519413544 0.387235405914343 no 1280 0.394498411720536 1921 17151580
SGTC_1971 st069429 63.5 µM 0.267540959892929 0.387263053726522 no 1281 0.394526340840646 1956 1246522 YGL099W LSG1
SGTC_2080 5212524 12.4 µM 0.267118099404904 0.387424190301092 no 1282 0.394689116223354 1979 260183
SGTC_2452 5863136 48.41 µM 0.266831669153653 0.387533349352389 no 1283 0.394799384770095 1812 2184096
SGTC_896 0964-0007 44.5 µM 0.266118613421512 0.387805134694566 no 1284 0.395073930140118 1956 6756758
SGTC_1788 fluconazole 20 µM 0.265597729848305 0.388003707256139 no 1285 0.39527451707063 1794 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_741 4582-0002 126 µM 0.264123139025868 0.388566013178378 no 1286 0.395842517218729 1806 2912688
SGTC_3265 9137266 49.47 µM 0.264091295421643 0.388578158685241 no 1287 0.395854785555637 2012 17224265
SGTC_2125 5246583 200 µM 0.263983111896853 0.388619421905365 no 1288 0.395896466028082 1996 835267
SGTC_2650 prasterone 100 µM 0.262919945372254 0.389025000303918 no 1289 0.396306141408241 1882 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1331 1472-0049 76.2 µM 0.262043061684118 0.389359606286955 no 1290 0.396644121679928 1803 24051409
SGTC_384 k007-0144 5.16 µM 0.261117943072807 0.38971270695409 no 1291 0.397000777494432 1865 6824886
SGTC_2090 5301565 104.445 µM 0.258465763719308 0.390725498512667 no 1292 0.398023734020451 1856 2056344
SGTC_1500 4488-1866 171 µM 0.258403174755195 0.390749408436347 no 1293 0.39804788334111 1939 2900003
SGTC_979 1426-2828 121 µM 0.257074390818398 0.391257121180716 no 1294 0.398560673250409 1914 747872
SGTC_2324 6149169 200 µM 0.256719489440421 0.391392756229743 no 1295 0.398697662627774 1934 2888231
SGTC_446 go6976 132 µM 0.254296597104115 0.39231908134577 no 1296 0.399633214267063 1991 3501 A protein kinase C inhibitor.
SGTC_305 1682-2595 20.8 µM 0.254264035778434 0.392331534426857 no 1297 0.399645791112786 1887 226033
SGTC_1926 methyl fluorone black 53.6 µM 0.25367263006785 0.392557736754592 no 1298 0.399874240288427 1873 72721 Reacts with homocysteine.
SGTC_2344 7990960 76.95 µM 0.253394711440668 0.39266404830469 no 1299 0.399981606997812 1830 140813
SGTC_3095 9117207 49.47 µM 0.253249820864104 0.392719476128191 no 1300 0.40003758474241 1989 17015229
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.251861926292745 0.393250524642538 no 1301 0.400573894734831 1877 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1325 1431-0015 227 µM 0.251181122155042 0.393511092649005 no 1302 0.400837039564847 1793 1103340
SGTC_2867 9039098 71.43 µM 0.251082460659058 0.393548857879482 no 1303 0.400875178002536 1818 6463460
SGTC_2821 7996764 71.43 µM 0.250778587260818 0.393665179545212 no 1304 0.400992648775366 1886 2987135
SGTC_1512 0259-0544 12.2 µM 0.249871734608902 0.394012375924101 no 1305 0.401343271249359 1890 18476
SGTC_1572 epiandrosterone 68.9 µM 0.248467890410998 0.394550015890163 no 1306 0.401886205485391 1898 441302 A steroid.
SGTC_2491 paeonol 100 µM 0.248348231899207 0.394595851649055 no 1307 0.401932491975801 1848 11092 Increases levels of cortical cytochrome oxidase.
SGTC_933 2914-0560 114 µM 0.248347249309877 0.394596228040587 no 1308 0.401932872068219 2020 463887
SGTC_2617 dihydrotanshinone i 20.83 µM 0.247848264214834 0.394787382414853 no 1309 0.402125905121402 1824 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2507 purpurin 79.67 µM 0.247379976472583 0.394966800095636 no 1310 0.402307084579771 1767 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_997 3996-0078 137 µM 0.247312782881432 0.394992546177242 no 1311 0.402333083349637 1874 735687
SGTC_161 4065-0411 162.148 µM 0.241529729617467 0.397210103293399 no 1312 0.404572288749826 1886 1906281 YLR208W SEC13
SGTC_2869 9037858 32.47 µM 0.239446990295269 0.398009564679981 no 1313 0.405379498266683 1967 27187042
SGTC_2890 9046729 58.44 µM 0.236660633321386 0.399079779783883 no 1314 0.406460038737019 1819 903329
SGTC_2568 diosmetin 100 µM 0.235549420610049 0.399506798945362 no 1315 0.406891162782398 2037 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_967 1306-0166 352 µM 0.234626194356944 0.399861669751784 no 1316 0.407249438419808 2018 4437607
SGTC_1222 0366-0074 1.18 µM 0.230973575162422 0.401266476243821 no 1317 0.408667665484646 2005 286520
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.230707606492437 0.40136881856845 no 1318 0.408770981902234 2008 1241132 A phosphatase inhibitor.
SGTC_3349 9149703 23.001 µM 0.229503097485295 0.401832387292548 no 1319 0.409238956713774 1952 4910494
SGTC_2106 5357045 167.29 µM 0.22735184667757 0.402660663476223 no 1320 0.410075080316262 1972 668842
SGTC_2846 9008642 19.48 µM 0.225659812510884 0.403312439032654 no 1321 0.410733008407318 1865 2992898
SGTC_1202 1988-0068 29.6 µM 0.225518215281503 0.403366994827417 no 1322 0.410788078284825 1824 2850480
SGTC_2287 7945887 168.79 µM 0.225156760128169 0.403506267893944 no 1323 0.410928663096248 2033 1245853
SGTC_2553 4-methylesculetin 85.09 µM 0.224754769628901 0.403661174095134 no 1324 0.411085027212648 1850 5319502
SGTC_390 dec-rvkr-cmk 16.7 µM 0.223959927695395 0.403967509240885 no 1325 0.411394242142496 1934 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2432 5630864 12.22 µM 0.22288173718317 0.40438314213635 no 1326 0.411813775252429 1890 5714970
SGTC_25 0118-0223 35.662 µM 0.222727222731722 0.404442714942683 no 1327 0.411873906412438 1992 5333628
SGTC_485 niflumic acid 177 µM 0.222473154208732 0.40454067548236 no 1328 0.411972784736908 1979 4488 A COX2 inhibitor.
SGTC_1001 4048-4355 44.4 µM 0.220777113905972 0.405194766357076 no 1329 0.412632992172698 1899 21824233
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.2206673744499 0.405237097359059 no 1330 0.412675718328762 1955 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_148 3253-0744 288.01 µM 0.220349371575174 0.405359770349143 no 1331 0.412799535978206 2004 6893655
SGTC_1164 k060-0068 93.7 µM 0.219390607424954 0.405729680041223 no 1332 0.413172893004094 1986 5963676
SGTC_1919 st067113 52.3 µM 0.218768472221315 0.405969756860443 no 1333 0.413415203747805 1901 1268243
SGTC_1530 rhein 70.4 µM 0.217772768960474 0.406354064056449 no 1334 0.413803081290369 2006 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_297 0986-0032 24 µM 0.217557531064831 0.406437150350861 no 1335 0.41388693857102 1911 2847425
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.217451170133863 0.406478209432937 no 1336 0.413928378534406 1992 368090
SGTC_2614 arthonioic acid 13.39 µM 0.215922491858083 0.407068446710349 no 1337 0.414524082327237 1953 6710684
SGTC_2778 tioconazole 65.09 nM 0.213867824097538 0.407862105904836 no 1338 0.415325066169344 1939 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1353 1498-1206 8.11 µM 0.212803367840916 0.408273423757088 no 1339 0.415740168377276 1926 6756808
SGTC_429 1112-0049 25.5 µM 0.211408890146334 0.408812418491068 no 1340 0.416284110090387 1852 2836170
SGTC_2638 epoxomicin 18 µM 0.211055457381329 0.408949055072118 no 1341 0.416421998566654 2037 9915668 A protesome inhibitor.
SGTC_1133 3473-0247 50 µM 0.210612330432869 0.40912038292319 no 1342 0.416594894917681 1806 711311
SGTC_130 0136-0219 337.655 µM 0.210171181721605 0.409290963167817 no 1343 0.416767035442134 2062 234244
SGTC_307 1501-1223 22.3 µM 0.208969850935619 0.409755572196146 no 1344 0.417235887238023 1956 2830329
SGTC_621 3584-0052 32.1 µM 0.20836359551984 0.409990086787965 no 1345 0.417472539526572 2061 2273927
SGTC_3229 9132204 49.47 µM 0.207515546173566 0.410318187259257 no 1346 0.417803626410792 1970 17682924
SGTC_17 0960-0276 49.807 µM 0.20685030272196 0.410575606200339 no 1347 0.418063384853681 1995 6821114
SGTC_754 3474-0146 171 µM 0.206489388143236 0.410715279845253 no 1348 0.418204326585492 1826 24762078
SGTC_2514 salinomycin 42.74 µM 0.205436321710214 0.411122880342651 no 1349 0.418615622389406 2074 23682228 A polyether potassium ionophore.
SGTC_1775 st081588 35.1725 µM 0.205344492080512 0.411158428527261 no 1350 0.418651492481753 2018 1426443 YGL099W LSG1
SGTC_1257 0669-0121 16 µM 0.203950481827585 0.411698153517786 no 1351 0.419196097632797 2029 4307855
SGTC_2661 dactinomycin 12.96 µM 0.203914312640828 0.411712159527189 no 1352 0.4192102301004 1989 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1360 1598-0022 39.8 µM 0.203111473226813 0.412023076739653 no 1353 0.419523952150665 2009 761525
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.202903372694688 0.412103677267363 no 1354 0.41960527904363 1899 688664
SGTC_1453 4237-0541 195 µM 0.202691495462429 0.412185744378329 no 1355 0.419688085420949 2053 739892
SGTC_2365 9042475 200 µM 0.20056797022698 0.41300846798838 no 1356 0.420518202579357 1933 6464479
SGTC_744 1594-0068 283 µM 0.199810681689796 0.413301959153662 no 1357 0.420814323504066 1919 668392
SGTC_1705 st027868 56.3335 µM 0.199600227470809 0.413383530406561 no 1358 0.420896624933261 2059 292948
SGTC_2830 7992007 71.43 µM 0.198145907734941 0.413947321196082 no 1359 0.421465453823316 1865 1952075
SGTC_910 3454-3003 490 µM 0.197856164323396 0.414059666190109 no 1360 0.421578800947084 2093 820824
SGTC_1682 st012968 530 nM 0.19726956506353 0.414287135475367 no 1361 0.421808297453105 1878 24207270
SGTC_1426 4048-4480 71.7 µM 0.196010788571711 0.414775356112634 no 1362 0.422300860868083 2039 14224343
SGTC_1613 st002381 52.1 µM 0.195190055091148 0.415093751275818 no 1363 0.422622082107863 2100 551167
SGTC_1233 0325-0408 14.2 µM 0.195059745507611 0.415144308682491 no 1364 0.422673087820247 2026 12874
SGTC_66 0109-0187 42.4 µM 0.193150418463061 0.41588524855182 no 1365 0.423420583896024 1862 759417
SGTC_149 3970-0822 46.1 µM 0.191618301427506 0.416480023476397 no 1366 0.424020602848982 1927 3114250 YBL034C STU1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.191455903749836 0.416543078241931 no 1367 0.424084212573664 1927 75037 A free radical scavenger.
SGTC_1300 1094-0077 113 µM 0.191239500867822 0.416627105151346 no 1368 0.424168978729566 1934 5532636
SGTC_2170 morpholine 200 µM 0.190890382179853 0.416762672208517 no 1369 0.424305737763459 2030 121171 Reacts with secondary amines.
SGTC_2265 7929201 200 µM 0.190889702655832 0.416762936085665 no 1370 0.424306003959902 2020 1265108
SGTC_3260 9137109 49.47 µM 0.190779726585629 0.41680564319625 no 1371 0.424349086392629 2076 17478346
SGTC_902 1120-0002 2.07 µM 0.190545374110273 0.416896652787821 no 1372 0.4244408955134 2011 3280475
SGTC_1882 5615643 20 µM 0.19008821921891 0.417074199377982 no 1373 0.424620000738187 2085 2253075
SGTC_2936 9038235 15.59 µM 0.188349544757932 0.417749607676532 no 1374 0.425301324592805 2017 4749415
SGTC_49 0717-0965 32.132 µM 0.188296811717241 0.417770096240959 no 1375 0.42532199226757 2036 5889349 YGL099W LSG1
SGTC_1932 st074806 40.9 µM 0.188220732228679 0.417799656080906 no 1376 0.425351810483507 2012 17251235
SGTC_2178 5812956 200 µM 0.188146276080721 0.417828585639574 no 1377 0.425380992868833 2076 5403383
SGTC_577 r071-0003 38.6 µM 0.187594659874934 0.418042927159311 no 1378 0.425597206364043 2013 4568517 YMR134W ERG29
SGTC_3121 9125696 49.47 µM 0.187251373159617 0.418176330378582 no 1379 0.425731773573285 2115 1235365
SGTC_1238 0333-0287 48.8 µM 0.18703523529062 0.418260327645138 no 1380 0.425816503311725 1978 7226
SGTC_914 3820-6779 408 µM 0.186612643036734 0.418424569670345 no 1381 0.425982176589521 1984 2893481
SGTC_2277 7947813 106.88 µM 0.186320667240135 0.418538055442015 no 1382 0.42609665056023 2056 1246798
SGTC_2467 5474540 200 µM 0.182022911099337 0.420209296035217 no 1383 0.427782372896407 2065 5413519
SGTC_1574 spiramycin 23.7 µM 0.181647387206848 0.42035539240391 no 1384 0.427929728914134 2037 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_786 4544-0069 423 µM 0.181199599270978 0.420529617209681 no 1385 0.42810545456548 2035 748821 YLR208W SEC13
SGTC_1828 st055811 49 µM 0.181101017132119 0.420567975525171 no 1386 0.428144143121532 2102 5877589
SGTC_244 nsc-207895 1.295 µM 0.180518399703162 0.420794687387382 no 1387 0.428372805397526 1960 42640
SGTC_1972 st070201 17.4 µM 0.18013119401258 0.420945373906674 no 1388 0.428524786926965 2105 2829099
SGTC_2253 7938677 135.83 µM 0.178037339019445 0.421760427030961 no 1389 0.429346825930111 2111 2301972
SGTC_139 0099-0334 718.624 µM 0.176742083498459 0.42226478573379 no 1390 0.429855491675714 2137 97690
SGTC_2870 9038528 12.99 µM 0.176091927950368 0.422517997491156 no 1391 0.430110861199423 2010 6463316
SGTC_3314 9135860 59.4275 µM 0.176034050861596 0.422540540049719 no 1392 0.430133595708218 2109 25252478
SGTC_824 1304-0008 100 µM 0.173870276721767 0.42338349027024 no 1393 0.430983706267513 1989 768245
SGTC_1933 st074711 15.9 µM 0.173138881209997 0.423668502493074 no 1394 0.431271131824624 2113 17250958
SGTC_1473 k844-0725 134 µM 0.172657218017933 0.42385622015649 no 1395 0.431460436865668 2100 54682906
SGTC_167 3672-0051 66.205 µM 0.172032570751393 0.424099688455703 no 1396 0.431705961475664 2029 3237971
SGTC_102 gallobenzophenone 83.616 µM 0.171702382234598 0.424228397497891 no 1397 0.431835756439229 2097 70837
SGTC_1988 st071872 53.4 µM 0.170437748187251 0.424721432452835 no 1398 0.432332943824202 2131 16414116
SGTC_285 1486-1325 46 µM 0.169201597805113 0.425203476513059 no 1399 0.432819036522673 2088 22310230
SGTC_1578 josamycin 24.2 µM 0.169178078052076 0.425212649264623 no 1400 0.4328282862076 1936 5282165 A P450 substrate.
SGTC_2681 menadione 3.18 µM 0.167341064173515 0.425929213102056 no 1401 0.433550847556773 2017 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_891 0929-0073 133 µM 0.16719847676443 0.425984842422012 no 1402 0.433606941457584 2075 5603632
SGTC_3261 9137475 49.47 µM 0.165351737028042 0.426705465627594 no 1403 0.434333569477259 2130 17027690
SGTC_636 0kpi-0074 126 µM 0.162521781775728 0.427810227086065 no 1404 0.435447488458595 2016 616434
SGTC_1443 4112-3303 14 µM 0.162440029893859 0.427842149943318 no 1405 0.435479675060417 2032 704433
SGTC_674 0498-0004 451 µM 0.162235409500371 0.427922053141911 no 1406 0.435560238200105 1959 4231473
SGTC_2640 pentamidine 10.38 µM 0.162072130595853 0.427985814824754 no 1407 0.435624526287779 2141 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.160590553163692 0.428564468087242 no 1408 0.436207947903761 2037 364106
SGTC_122 0236-0016 402.397 µM 0.159152131023603 0.429126413351626 no 1409 0.436774508485718 2113 6808838
SGTC_2007 4011539 71.82 µM 0.154554612574345 0.430923473974953 no 1410 0.438586226923489 2038 45595301
SGTC_375 3970-0961 9.27 µM 0.154499213228125 0.430945137062842 no 1411 0.438608065762178 2056 2898222
SGTC_573 3702-0553 84.7 µM 0.152377752334681 0.431774858415855 no 1412 0.439444501613691 2068 1222756
SGTC_422 cantharidin 155 µM 0.152349365714846 0.431785962713034 no 1413 0.43945569554788 1948 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_479 n-linoleoylglycine 10 µM 0.151651638840067 0.43205891690732 no 1414 0.439730851242563 2021 6433346 An anti-infammatory.
SGTC_981 1488-1094 54.9 µM 0.150885760516731 0.432358569621937 no 1415 0.440032916670729 2087 3449522
SGTC_2962 9082311 13.18 µM 0.150713824989831 0.432425845384385 no 1416 0.440100733524163 2030 16459453
SGTC_2360 9040895 200 µM 0.149622012323682 0.43285310075367 no 1417 0.440531420179015 2030 4914414
SGTC_1472 k841-0093 193 µM 0.149180477309549 0.433025907485096 no 1418 0.440705612227414 2110 X1472
SGTC_1415 3966-0071 78.1 µM 0.147654031916202 0.433623421860323 no 1419 0.441307905548032 2135 2893185
SGTC_2946 9065502 71.43 µM 0.147489240656532 0.433687937129238 no 1420 0.44137293578539 2164 16489101
SGTC_1242 0402-0103 60.1 µM 0.147327052314777 0.433751435088969 no 1421 0.44143694039771 2097 432868
SGTC_1193 1488-0126 41.5 µM 0.147060888800522 0.433855643817916 no 1422 0.441541980191474 2102 1384710
SGTC_1090 efavirenz 20.7 µM 0.147005652026949 0.433877270776716 no 1423 0.441563779559827 2079 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2030 5175110 200 µM 0.14633113031925 0.434141383489604 no 1424 0.441829995956209 2090 2831986
SGTC_2708 st078559 56 µM 0.144607566995658 0.434816387539939 no 1425 0.442510361219937 2148 17250902
SGTC_2715 st079500 56.4 µM 0.144038294763596 0.435039375102629 no 1426 0.442735115037398 2043 28246688
SGTC_996 3970-0799 1.8 µM 0.143330394403329 0.435316693001144 no 1427 0.44301462619191 2138 6615648 YGL040C HEM2
SGTC_2202 7226349 200 µM 0.14174527833783 0.435937772773681 no 1428 0.443640604524427 2115 844334
SGTC_763 3453-1109 128 µM 0.141032959780817 0.436216924800224 no 1429 0.443921952212187 2164 1560353
SGTC_2815 7968870 71.43 µM 0.140677222194829 0.436356347460667 no 1430 0.44406247008992 2073 2977326 YHR190W ERG9
SGTC_1785 bathophenanthroline 24 µM 0.140100692622869 0.436582320934209 no 1431 0.444290216678586 1985 72812 An iron chelator.
SGTC_1738 st035555 74 µM 0.139978415009304 0.436630250882028 no 1432 0.444338522395127 2081 5331140
SGTC_1962 st076595 64.5 µM 0.13994073940596 0.436645019019706 no 1433 0.444353406292033 2101 279619
SGTC_579 4491-1009 110 µM 0.139692097661307 0.436742484185039 no 1434 0.444451635168787 2212 1271041
SGTC_2443 5493264 126.67 µM 0.138575613125391 0.437180182605517 no 1435 0.444892757627778 2116 5340055
SGTC_1304 1165-0502 251 µM 0.138401595879102 0.437248409992773 no 1436 0.444961517913075 2094 767425
SGTC_799 1310-0557 151 µM 0.138024925908552 0.43739609834133 no 1437 0.445110359029252 2056 5354492
SGTC_3299 9121982 43.1275 µM 0.137040984091951 0.437781932722545 no 1438 0.445499200035666 2045 17594604 YPL160W CDC60
SGTC_1784 st039334 36.3 µM 0.136914483767532 0.437831541758706 no 1439 0.44554919513009 2178 3496984
SGTC_271 rotenone 740 µM 0.134433785118154 0.438804582167089 no 1440 0.446529783719358 2104 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2918 7977171 22.06 µM 0.133552337848215 0.43915041440199 no 1441 0.446878287663016 2125 2236483
SGTC_1845 st056753 3.01 µM 0.13156068505157 0.439932001899648 no 1442 0.44766589196913 2109 5375839
SGTC_313 3474-0040 5.03 µM 0.13074280244091 0.4402530328783 no 1443 0.447989385743132 2117 1043375 YIL048W NEO1
SGTC_1846 st056244 14.8 µM 0.130526074418024 0.440338108413558 no 1444 0.448075113101027 2098 5393182
SGTC_1246 0422-0085 105 µM 0.12807193794071 0.441301659049423 no 1445 0.449046021708208 2178 264295
SGTC_1864 st057645 30.4 µM 0.127283588826556 0.441611257136143 no 1446 0.449357974436892 2203 688666
SGTC_2988 9073640 71.4286 µM 0.127218888870836 0.441636667494377 no 1447 0.449383577846869 2127 9102229
SGTC_2154 5570129 200 µM 0.127024789702022 0.441712899735626 no 1448 0.449460389064481 2172 673366
SGTC_2746 daunorubicin 9.88 µM 0.125836783303709 0.442179534924872 no 1449 0.449930562163524 2180 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3092 9117248 49.47 µM 0.124909713609641 0.442543732965811 no 1450 0.450297514127432 2203 17141857
SGTC_829 1635-0120 117 µM 0.124169224503695 0.442834667981794 no 1451 0.450590644458624 2176 285054
SGTC_3195 9113082 49.47 µM 0.124020228886249 0.442893211455748 no 1452 0.450649629189264 2213 17018038
SGTC_603 3794-0023 45.9 µM 0.124008972271334 0.442897634464313 no 1453 0.450654085528386 2191 3802260
SGTC_2229 7354935 190 µM 0.12396855684328 0.442913514766326 no 1454 0.450670085492102 2176 318112
SGTC_2008 4012253 172 µM 0.123102027333694 0.443254019394064 no 1455 0.451013152956296 2115 603940
SGTC_1620 st003704 16.5 µM 0.123046543467597 0.44327582332842 no 1456 0.451035120808129 2182 2834414
SGTC_2158 5657123 3.6195 µM 0.122648455823984 0.443432268016123 no 1457 0.451192740938072 2186 2858827
SGTC_1197 1601-0112 267 µM 0.121170260181072 0.444013261926279 no 1458 0.451778089729429 2080 7350313
SGTC_3154 9100113 49.47 µM 0.121032445554149 0.444067435102461 no 1459 0.451832668129215 2078 25237525
SGTC_2934 9036370 36.88 µM 0.120890446516097 0.444123254210557 no 1460 0.451888904623663 2144 6462800
SGTC_1877 wortmannin 25 µM 0.119766525351459 0.444565100987981 no 1461 0.45233404996226 2202 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2794 7785382 27.27 µM 0.119480068763948 0.444677726616263 no 1462 0.452447514868671 2246 2205081
SGTC_2138 5575593 77.673 µM 0.119026480029961 0.444856072426276 no 1463 0.45262718843819 2133 762213
SGTC_1105 epirubicin 18.1 µM 0.117915092484149 0.445293104185074 no 1464 0.453067467301928 2051 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1897 st060201 15 µM 0.117846181062701 0.445320204469793 no 1465 0.453094768633515 2022 611878
SGTC_2272 7805186 180 µM 0.117638383606405 0.445401924984037 no 1466 0.453177095185497 2212 2956062 YPR165W RHO1
SGTC_2912 7964298 10.93 µM 0.116912644395825 0.445687354651809 no 1467 0.453464639046403 2090 2975850
SGTC_13 0199-0087 65 µM 0.116904776574954 0.445690449181644 no 1468 0.453467756475881 2202 4589825
SGTC_1390 3413-2614 145 µM 0.115369837871622 0.446294226237544 no 1469 0.454075992594414 2079 3421432
SGTC_3114 9122766 49.47 µM 0.115184679383798 0.446367067849714 no 1470 0.454149370963382 2059 17176985
SGTC_755 1995-0008 37.3 µM 0.113459136796461 0.447045985456576 no 1471 0.454833278972108 2208 689533
SGTC_2216 7189485 200 µM 0.112901180470668 0.447265547607243 no 1472 0.455054450218047 2196 731273
SGTC_1768 st044301 37.178 µM 0.112647026938415 0.447365565270326 no 1473 0.455155200097769 2161 3931349
SGTC_1484 3473-2379 286 µM 0.112642158592303 0.447367481155208 no 1474 0.455157130003845 2207 671917
SGTC_3164 9100705 49.47 µM 0.112252227692093 0.447520938222261 no 1475 0.455311709549028 2207 17174235
SGTC_2828 7998861 71.43 µM 0.112146438189563 0.447562572971962 no 1476 0.455353648642725 2214 2988188
SGTC_825 1988-2224 89.6 µM 0.111828119205472 0.447687854775782 no 1477 0.455479845729037 2120 1180859
SGTC_314 1671-0008 2.74 µM 0.109006377274251 0.448798643389391 no 1478 0.456598716073264 2143 3913060
SGTC_2323 6148992 148.28 µM 0.107968218230494 0.449207419827149 no 1479 0.457010451489258 2120 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_301 4119-0100 24.5 µM 0.107249944209211 0.449490272714778 no 1480 0.457295347070022 2123 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2813 7971799 71.43 µM 0.104116416770332 0.45072453926613 no 1481 0.458538481482456 2134 2234054
SGTC_3242 9133940 49.47 µM 0.10357946810997 0.450936086386631 no 1482 0.458751541040687 2193 17248444
SGTC_2543 pimpinellin 60.67 µM 0.102645655204182 0.451304023308622 no 1483 0.459122103285872 2091 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2756 carbadox 75.1 µM 0.102394624265912 0.4514029405819 no 1484 0.459221725230334 2124 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1184 1269-1718 139 µM 0.0999304344695082 0.452374099411108 no 1485 0.460199777033544 2216 5403821
SGTC_1925 st057770 10.1 µM 0.0966627966417659 0.453662342763746 no 1486 0.461497092704144 2004 5989122
SGTC_1900 st060200 72.8 µM 0.0961353865255905 0.453870316580018 no 1487 0.461706523534156 2180 688945
SGTC_2395 5646831 180.19 µM 0.0949940327885194 0.454320430233941 no 1488 0.462159783316327 2195 6808628
SGTC_1270 0831-1170 17.3 µM 0.0921770087602753 0.455431624918335 no 1489 0.463278702307516 2230 6764716
SGTC_3253 9135987 49.47 µM 0.0917152837489813 0.455613789052116 no 1490 0.463462126949233 2218 4182430
SGTC_3022 9087993 49.47 µM 0.0912267006433966 0.455806559657392 no 1491 0.463656229681518 2255 17173644
SGTC_1429 4049-0205 9.46 µM 0.0908527571164776 0.455954106215009 no 1492 0.463804794616217 2234 22774478
SGTC_1163 k060-0048 49.9 µM 0.0907356574136956 0.456000311388207 no 1493 0.463851318481119 2242 6809982
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0896152370426392 0.456442436589895 no 1494 0.464296487859109 2185 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1839 st053978 48 µM 0.0879340040213956 0.45710596314058 no 1495 0.464964564986967 2263 3788398
SGTC_2317 5986382 200 µM 0.0874820560763976 0.457284352380662 no 1496 0.465144173960093 2209 877883
SGTC_1179 1021-1431 9.29 µM 0.0873821239921506 0.45732379792851 no 1497 0.465183889004925 2191 2840958
SGTC_2635 hydroquinidine 100 µM 0.0857833644634256 0.457954922883334 no 1498 0.465819315480335 2201 442912 An experimental heart treatment.
SGTC_493 zm226600 134 µM 0.0852536551316141 0.45816405395216 no 1499 0.466029867589715 2221 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2625 euphol 100 µM 0.0851400602171919 0.45820890312581 no 1500 0.466075021232203 2273 6708538 A triterpene alcohol.
SGTC_3192 9110362 49.47 µM 0.0846770780667904 0.458391701726025 no 1501 0.466259059778546 2236 16649480
SGTC_2879 9041815 71.43 µM 0.0834603291568957 0.458872150864575 no 1502 0.466742760022839 2264 4942971
SGTC_3073 9114972 49.47 µM 0.0831904260006653 0.458978733804229 no 1503 0.466850062648384 2276 41905075
SGTC_1157 4092-0394 27.6 µM 0.0815969082903891 0.459608063067778 no 1504 0.467483629962364 2235 3659885
SGTC_2707 st078556 66.6 µM 0.0811357528791268 0.45979020650922 no 1505 0.467666996359628 2277 17250899
SGTC_1471 k673-0312 37 µM 0.0806335524417266 0.459988571181956 no 1506 0.467866691041709 2269 24099884
SGTC_2595 hexamethylquercetagetin 100 µM 0.0805786680748167 0.46001025061967 no 1507 0.467888515719676 2203 386331
SGTC_318 1488-0629 67.2 µM 0.0804721011866947 0.460052345098943 no 1508 0.467930892142539 2157 3662576
SGTC_2903 5923464 63.88 µM 0.0791756522113489 0.460564484956213 no 1509 0.468446455252169 2269 2876576
SGTC_1618 st003135 44.5 µM 0.0790772111439311 0.46060337508893 no 1510 0.468485604806514 2264 1270615
SGTC_165 k038-0023 64.381 µM 0.079062703579549 0.460609106479865 no 1511 0.468491374423122 2250 46368543
SGTC_2093 5331342 194.4 µM 0.0777264693887576 0.461137037091725 no 1512 0.469022819134437 2260 33839
SGTC_212 3807-4682 38.772 µM 0.0765210208537092 0.461613354605743 no 1513 0.469502295390749 2233 3125501 YBL034C STU1
SGTC_2259 7964009 200 µM 0.0748499804759855 0.462273735693015 no 1514 0.470167037324453 2220 313134
SGTC_950 1165-0508 94.1 µM 0.0744721616085024 0.462423061009794 no 1515 0.47031734572955 2195 6148369
SGTC_984 1492-0255 2.91 µM 0.0732082117428913 0.462922650176793 no 1516 0.470820215949433 2207 1585198
SGTC_2005 4024620 188 µM 0.0728482424953621 0.463064942454196 no 1517 0.47096344047456 2262 236743
SGTC_2114 5491910 81.25 µM 0.0726556319964535 0.46314108141829 no 1518 0.471040077862618 2245 2849228
SGTC_2484 5809818 12.04 µM 0.0709853018600519 0.463801419545829 no 1519 0.471704726697778 2226 2870548
SGTC_460 trequinsin 123 µM 0.0701259973498077 0.464141170716961 no 1520 0.472046687370834 2280 5537 A vasodilator.
SGTC_164 4100-3994 89.624 µM 0.069339391150909 0.464452201415861 no 1521 0.472359735785307 2281 4615967
SGTC_1103 duloxetine 36.1 µM 0.0692631760943578 0.464482338646873 no 1522 0.472390068267816 2256 60835 A selective serotonin reuptake inhibitor.
SGTC_581 0958-0271 211 µM 0.0686692334578268 0.464717204542516 no 1523 0.472626454259436 2267 4591145
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0681300685190376 0.46493042004907 no 1524 0.472841047371186 2267 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_721 1187-1332 279 µM 0.067581929863554 0.465147194579374 no 1525 0.473059220193564 2270 25730
SGTC_1352 1496-0991 99 µM 0.0665554974166753 0.465553149588963 no 1526 0.473467787531243 2256 3000039
SGTC_79 0052-0007 94.094 µM 0.0660782235409519 0.465741924096892 no 1527 0.473657774024862 2285 2801472
SGTC_3118 9124250 49.47 µM 0.0655534598660139 0.465949490979018 no 1528 0.47386667150608 2186 1504786
SGTC_21 0849-0113 22.993 µM 0.0655274450982359 0.46595978119383 no 1529 0.473877027630329 2265 1560156
SGTC_312 4092-0653 6.84 µM 0.0651482581499866 0.466109772241206 no 1530 0.474027978783269 2251 1148278
SGTC_1028 k015-0029 4.8 µM 0.0641309466137193 0.466512203335237 no 1531 0.474432980360936 2299 4588309
SGTC_2377 9073351 62.6 µM 0.0637462107617136 0.466664407222101 no 1532 0.474586154339454 2235 7337946 YHR072W ERG7
SGTC_463 ikarugamyin 104 µM 0.063193860351549 0.466882928984591 no 1533 0.474806066869661 2301 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3293 9120939 62.045 µM 0.0627384238605728 0.467063117017459 no 1534 0.474987399915109 2272 934087
SGTC_1684 st024538 14.6195 µM 0.0626602696136097 0.467094038495649 no 1535 0.475018517723166 2265 6732859
SGTC_2068 5226020 147 µM 0.0624788163142874 0.467165830679429 no 1536 0.475090765554338 2252 1810509
SGTC_1285 0929-0069 65.5 µM 0.0604640631109285 0.467963041096349 no 1537 0.475893018471739 2239 1206237
SGTC_3111 9122088 49.47 µM 0.0604532010116226 0.467967339432315 no 1538 0.475897343909907 2297 16876704
SGTC_634 1611-4317 11.2 µM 0.0597746379564849 0.468235866915409 no 1539 0.476167562713399 2311 2843522
SGTC_3232 9132874 49.47 µM 0.0594362592346419 0.468369778798254 no 1540 0.476302316701323 2270 3784940
SGTC_1370 2001-0092 44.6 µM 0.0593500311272755 0.468403903763249 no 1541 0.476336656118723 2270 790957
SGTC_2566 crystal violet carbinol 226 nM 0.0583703763717913 0.468791620549688 no 1542 0.476726805378946 2108 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1677 st019204 53.9 µM 0.0571711386056629 0.469266281698612 no 1543 0.477204434300338 2157 3945625
SGTC_3163 9099914 49.47 µM 0.0555850358952157 0.469894131893439 no 1544 0.477836192849528 2313 16268368
SGTC_954 1189-0853 2.85 µM 0.0555187457107532 0.469920374145618 no 1545 0.477862598032068 2318 2828194
SGTC_924 2046-0044 21.3 µM 0.0552478103503901 0.470027630507373 no 1546 0.477970519960388 2316 3623589
SGTC_1735 st034310 56.75 µM 0.054513902541128 0.470318176691517 no 1547 0.478262866217122 2231 871153
SGTC_2123 5259487 200 µM 0.0541504032247879 0.470462088010739 no 1548 0.478407667579137 2293 2173474
SGTC_2485 5633444 17.78 µM 0.0529073900552225 0.470954232596371 no 1549 0.478902848116319 2244 5724239
SGTC_3158 9100007 49.47 µM 0.0525875423607004 0.471080876683971 no 1550 0.479030271496323 2269 19297233
SGTC_2845 9003024 42.97 µM 0.0523843698883332 0.471161324593745 no 1551 0.479111214019565 2282 2990173
SGTC_2687 chenodiol 100 µM 0.0523418219614661 0.471178171965056 no 1552 0.479128164931796 2259 5702181 A cholesterol synthesis inhibitor.
SGTC_789 1309-1135 70.6 µM 0.051726508988605 0.471421818403495 no 1553 0.479373307195744 2319 3092424
SGTC_2776 terbinafine 19.92 µM 0.0512811997418589 0.471598154878116 no 1554 0.479550724411917 2313 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_385 1494-0393 12.4 µM 0.0511190508193315 0.471662365056029 no 1555 0.479615327739957 2266 3090647
SGTC_2085 5307070 144.047 µM 0.0502531579068232 0.472005266830215 no 1556 0.47996032557382 2282 2840351
SGTC_1851 st056236 18.9 µM 0.0491929677528979 0.472425140380466 no 1557 0.480382757701818 2318 5393171
SGTC_1015 4130-4525 82 µM 0.0485749016018299 0.472669931044364 no 1558 0.480629035983684 2270 1363237
SGTC_2439 5492030 7.2 µM 0.0477701065978345 0.472988692809441 no 1559 0.480949730413065 2319 5722370
SGTC_1834 st055981 52.8 µM 0.0477270939763417 0.473005729660374 no 1560 0.480966870416234 2310 471719 YDL150W RPC53
SGTC_2136 5328288 199.296 µM 0.047001868160334 0.473292991455745 no 1561 0.481255869299683 2284 262395
SGTC_2973 9094665 17.96 µM 0.0461279825875307 0.473639155788213 no 1562 0.481604121430898 2298 25237061 YIL048W NEO1
SGTC_1267 0828-0272 9.49 µM 0.0460515068096973 0.473669450392564 no 1563 0.481634598464257 2307 745334
SGTC_1465 k213-0056 144 µM 0.0453390892641303 0.473951670018851 no 1564 0.481918515365897 2214 24048857 YMR208W ERG12
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0447752672390328 0.474175033760432 no 1565 0.48214321959998 2269 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2341 7987486 176.74 µM 0.0441924822837103 0.474405918388561 no 1566 0.482375487234679 2318 1258686
SGTC_353 1988-1175 58.3 µM 0.0439966472484286 0.474483505199472 no 1567 0.48245353819478 2282 2788357
SGTC_1061 3448-9325 110 µM 0.0421832678594019 0.475201983641741 no 1568 0.483176300500526 2339 723482
SGTC_2099 5377090 177.372 µM 0.0405939990207325 0.47583173370988 no 1569 0.483809784151396 2286 2243829
SGTC_2904 7225135 42.03 µM 0.0398659599907789 0.4761202404838 no 1570 0.484099994754918 2329 4446116
SGTC_52 0329-0193 875 nM 0.0394556154067048 0.476282857061581 no 1571 0.484263569857263 2314 3739292
SGTC_1096 rimcazole 32.2 µM 0.0388544166609143 0.476521114882813 no 1572 0.484503229668785 2328 18528119 A dopamine reuptake inhibitor.
SGTC_3170 9103054 49.47 µM 0.0385347218445508 0.476647814829299 no 1573 0.484630674002324 2315 16432970
SGTC_1891 st059073 26.2 µM 0.0381776129022202 0.476789345357097 no 1574 0.484773035098341 2343 688754
SGTC_3093 9117344 49.47 µM 0.0381723931047629 0.476791414105231 no 1575 0.484775115979423 2284 24824913
SGTC_1187 1391-0724 117 µM 0.0374758520683014 0.477067477909038 no 1576 0.485052796938121 2255 6997986
SGTC_1215 3852-0577 11.2 µM 0.037394617768589 0.477099674649119 no 1577 0.485085182034748 2331 2884876
SGTC_1072 oxiconazole 14.9 nM 0.0372629766981088 0.477151850135604 no 1578 0.485137662646554 2336 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_90 0870-0863 4.608 µM 0.0362455347701828 0.477555122896215 no 1579 0.485543289164 2332 1738164
SGTC_2929 9013348 24.6 µM 0.035166439824598 0.477982857522151 no 1580 0.485973511405133 2324 2995952
SGTC_790 1575-0012 79.1 µM 0.0347965858116318 0.478129467135262 no 1581 0.486120971556081 2346 378741 YLR208W SEC13
SGTC_197 4544-0043 41.561 µM 0.0347320035400897 0.478155067761398 no 1582 0.486146720590479 2345 896523
SGTC_613 3914-0030 117 µM 0.0346361482301948 0.478193065289561 no 1583 0.486184938331781 2334 1145395
SGTC_40 0327-0103 19.753 µM 0.0341377173677762 0.478390648983978 no 1584 0.486383665946019 2327 409036
SGTC_998 3996-0085 177 µM 0.0341002586824358 0.478405498250438 no 1585 0.48639860110379 2314 715391
SGTC_227 fluconazole 33.516 µM 0.0337491572716166 0.47854468233656 no 1586 0.486538589721917 2313 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2155 5570423 76 µM 0.0335473755595978 0.4786246740951 no 1587 0.486619043420149 2299 797402
SGTC_3235 9132602 49.47 µM 0.0322210787409425 0.479150475506392 no 1588 0.48714787325043 2296 4912240
SGTC_111 0083-0039 52.457 µM 0.0320678416927716 0.47921122765439 no 1589 0.487208974412767 2348 759313
SGTC_1351 1496-0003 46.5 µM 0.0316288298081028 0.479385280367534 no 1590 0.487384026012377 2337 3891978
SGTC_992 3909-8734 162 µM 0.030366207369878 0.479885887383324 no 1591 0.487887497516299 2340 4288319
SGTC_1198 1612-1005 86.7 µM 0.0302632183069492 0.479926722098756 no 1592 0.487928565333278 2330 6998509
SGTC_3047 9092122 49.47 µM 0.0301789033745576 0.479960152759516 no 1593 0.487962186767723 2332 17173831
SGTC_1722 st034304 3.6505 µM 0.0293854633357694 0.480274756631805 no 1594 0.488278583188341 2328 4036148 YLR033W RSC58
SGTC_392 N-ethylmaleimide 8.33 µM 0.0293474885900481 0.480289814162524 no 1595 0.488293726388917 2332 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1999 st074831 12.5 µM 0.0281196104239766 0.480776700482385 no 1596 0.488783376700292 2310 17112523
SGTC_771 0250-0039 27.3 µM 0.0278704705052263 0.480875494603652 no 1597 0.488882730206953 2340 3005115
SGTC_184 1494-0393 24.714 µM 0.026847686144225 0.481281082487975 no 1598 0.489290609433239 2338 3090647
SGTC_1657 st012939 43.4 µM 0.0256082405434999 0.481772613897929 no 1599 0.489784906611743 2344 24207257
SGTC_2471 5466956 24.79 µM 0.0253532823116374 0.481873727063816 no 1600 0.489886587215493 2289 724419
SGTC_1171 0368-0077 21.4 µM 0.0251299574636692 0.481962295793438 no 1601 0.489975652561387 2350 3239779
SGTC_299 1273-0059 1.44 µM 0.0251196559051973 0.481966381325164 no 1602 0.489979760991676 2354 2848077
SGTC_1956 st077085 54 µM 0.0239722702713131 0.482421438829961 no 1603 0.490437363733286 2344 24208685
SGTC_26 0302-0163 425.158 µM 0.0211749600530647 0.483530957489465 no 1604 0.491553044393228 2357 3100915
SGTC_2284 7945075 39.21 µM 0.0204391592675281 0.483822825349548 no 1605 0.491846522894665 2359 1245402
SGTC_2026 5148700 152 µM 0.020258786354111 0.483894374653561 no 1606 0.491918466379223 2359 79838
SGTC_2528 xanthyletin 44.79 µM 0.0200922067252017 0.48396045297642 no 1607 0.491984908512138 2357 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_778 3456-2434 196 µM 0.0195936524436458 0.484158220664204 no 1608 0.4921837637394 2367 5539063
SGTC_2278 7948257 134.34 µM 0.0195329287515653 0.484182308948762 no 1609 0.492207984352261 2379 1247028
SGTC_2743 auranofin 4.32 µM 0.0185952850271526 0.484554267072278 no 1610 0.492581982095107 2356 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1631 benzylvanillin 81.9 µM 0.018524993054184 0.484582152058073 no 1611 0.492610019705495 2340 75506
SGTC_1763 st044482 94.5 µM 0.0183809526331263 0.484639293456632 no 1612 0.492667473736759 2366 88505
SGTC_2034 5197015 53.07 µM 0.0178044050260635 0.484868015294477 no 1613 0.492897445307591 2358 780676
SGTC_3074 9116018 49.47 µM 0.0172558414834291 0.485085640214987 no 1614 0.49311625687194 2365 17027303
SGTC_3281 9140613 49.47 µM 0.0171559134275769 0.485125283933456 no 1615 0.493156116497899 2328 16013766
SGTC_2786 7743617 45.45 µM 0.0162361574671867 0.485490178766485 no 1616 0.493522994886586 2358 583674
SGTC_2520 obtusaquinone 4.71 µM 0.0157181917267621 0.485695676710701 no 1617 0.493729606945307 2367 5967872
SGTC_2299 7976368 114.88 µM 0.0130236259544033 0.486764779912446 no 1618 0.494804471836177 2372 2979718
SGTC_647 0140-0236 81 µM 0.011285420538403 0.487454485950387 no 1619 0.495497864161198 2373 990837
SGTC_2753 fluvastatin 17.09 µM 0.0110826034393774 0.487534964640927 no 1620 0.495578771416865 2366 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_934 2950-0684 338 µM 0.0107379537665517 0.487671724264529 no 1621 0.495716258559523 2394 1121253
SGTC_3105 9121040 49.47 µM 0.0105171549448365 0.487759339686968 no 1622 0.495804339570498 2392 41448907
SGTC_2455 5377712 9.75 µM 0.0103312862339087 0.487833094912012 no 1623 0.495878486429113 2366 2243908
SGTC_2823 7987624 58.44 µM 0.0100026249702854 0.487963513175218 no 1624 0.49600959652611 2375 2239440
SGTC_806 3966-4455 5.86 µM 0.00876250876071219 0.488455623416085 no 1625 0.496504309507116 2364 714982
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.00797027605109207 0.488770011128489 no 1626 0.49682035356145 2376 689007
SGTC_1292 0kpi-0043 232 µM 0.00750515067765625 0.488954593620303 no 1627 0.497005906182123 2385 3333905
SGTC_3096 9117468 49.47 µM 0.00712534881686679 0.489105317693431 no 1628 0.497157421147601 2392 41316311
SGTC_733 4069-0007 56.1 µM 0.00700341482361389 0.489153707434813 no 1629 0.497206064559096 2389 5717425 YNL287W SEC21
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.00655102572346508 0.489333240314761 no 1630 0.497386537552125 2388 6708760
SGTC_707 0865-0008 204 µM 0.00645749894459926 0.489370357156133 no 1631 0.497423848549313 2390 723043
SGTC_1273 0849-0096 14.1 µM 0.00603380640887009 0.489538504035922 no 1632 0.49759287411772 2391 5286025
SGTC_2723 salbutamol 83.58 µM 0.00555301692404857 0.489729312696401 no 1633 0.497784678150494 2392 9884233 β2-adrenoceptor agonist
SGTC_3011 9081274 71.4286 µM 0.00536939775378602 0.489802185395131 no 1634 0.497857930508525 2388 6625322
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.00521878907644397 0.489861957517155 no 1635 0.497918013835659 2394 756377
SGTC_1516 st013856 110 µM 0.00461788634499702 0.490100440261656 no 1636 0.498157736438568 2383 5281404 A mutagen and neurotoxin.
SGTC_1831 st055328 12 µM 0.00367514420206934 0.490474597321954 no 1637 0.498533832891733 2398 1103068
SGTC_959 1222-0044 107 µM 0.00359826024300068 0.490505111528847 no 1638 0.498564504950853 2399 6083612
SGTC_3307 9126885 69.2785 µM 0.0035861417995942 0.490509921180742 no 1639 0.498569339479109 2396 24824909
SGTC_1256 0570-0116 285 µM 0.000932508039437671 0.491563145768317 no 1640 0.49962798317017 2402 410638
SGTC_397 arbidol 50 µM 0.000862362234621686 0.491590987398499 no 1641 0.499655967286229 2403 131410 A RNA synthesis inhibitor.
SGTC_2486 5283202 22.39 µM 0.000351927009825615 0.491793585896563 no 1642 0.499859601439063 2405 1377751
SGTC_1412 3909-8563 178 µM -0.000244072946487475 0.49203014884474 no 1643 0.499902628983111 2409 23767530
SGTC_2764 methyldopa 94.69 µM -0.000646450411260217 0.492189861183776 no 1644 0.499742103616728 2408 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_364 0083-0097 67.7 µM -0.00107083916505814 0.492358311636795 no 1645 0.499572797063194 2408 5207356
SGTC_1066 ketoconazole 628 nM -0.0020155826589442 0.492733308679421 no 1646 0.499195899402156 2407 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_322 k048-0136 19.3 µM -0.00279905135842711 0.493044295802117 no 1647 0.49888334152622 2422 6823282
SGTC_280 3448-3607 3.04 µM -0.00320239516366936 0.493204399237522 no 1648 0.498722431354309 2401 626179
SGTC_1359 1582-0056 520 nM -0.00361010672630243 0.493366237524574 no 1649 0.498559778918486 2414 3661189
SGTC_3000 9075062 71.4286 µM -0.00383801840501664 0.493456705967815 no 1650 0.498468855944338 2422 17057871
SGTC_1388 3346-4487 254 µM -0.00426376923933741 0.493625706609036 no 1651 0.498299007330486 2419 3345614
SGTC_264 promethazine 12.5 mM -0.00480691425332559 0.493841308208856 no 1652 0.498082326051185 2414 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_641 4092-0595 30 µM -0.00518040282324621 0.493989565672642 no 1653 0.497933327528035 2415 786260
SGTC_2522 biochanin a 4.94 µM -0.00562035388040332 0.494164206693397 no 1654 0.497757815010793 2418 5280373 A possible chelator.
SGTC_672 1441-0018 53.7 µM -0.0062418344497934 0.494410908762498 no 1655 0.497509884500078 2426 251141
SGTC_2397 5161689 200 µM -0.00664548552163621 0.494571142685849 no 1656 0.497348854365165 2425 2259942
SGTC_2792 7535235 81.82 µM -0.00705856445229084 0.49473512001252 no 1657 0.497184063584285 2439 1281891
SGTC_2059 5238311 157 µM -0.00871326043093574 0.495391982835027 no 1658 0.496523955998076 2415 703021
SGTC_1521 st012942 49.4 µM -0.00903918646957821 0.495521366861131 no 1659 0.496393935443641 2434 24207259
SGTC_1324 1418-0026 34.4 µM -0.0115392304753719 0.496513832938391 no 1660 0.49539661524003 2453 1372513
SGTC_1119 parthenolide 318.541 nM -0.0122981465250396 0.496815111560437 no 1661 0.495093873051612 2470 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2291 7917025 104.35 µM -0.0123709016989717 0.496843994403325 no 1662 0.495064850144483 2430 2964612
SGTC_2980 9014342 25.29 µM -0.0125977771066693 0.496934061048487 no 1663 0.49497434700529 2491 2996599
SGTC_1940 st075990 51.1 µM -0.0129144639162381 0.49705978193578 no 1664 0.494848017526332 2547 1084979
SGTC_1702 st027038 51 µM -0.0134053677985444 0.497254665496249 no 1665 0.494652192171616 2441 5521182
SGTC_469 w7 172 µM -0.0135243075922125 0.497301883415227 no 1666 0.49460474636033 2429 45115570 A P450 inhibitor.
SGTC_645 0845-0943 5.41 µM -0.0139210495569272 0.49745938631172 no 1667 0.494446484119267 2445 1885106
SGTC_1853 st056710 91.2 µM -0.0146916673276312 0.497765315560435 no 1668 0.494139083575845 2438 269167
SGTC_2335 9018011 154.17 µM -0.0154424930518075 0.498063388786388 no 1669 0.493839581454244 2455 6458208
SGTC_347 4534-1311 26.2 µM -0.0156933350750853 0.498162971786481 no 1670 0.493739522091645 2429 2862016
SGTC_558 k064-0027 21.3 µM -0.0157801093565595 0.498197420759306 no 1671 0.493704908448128 2448 5088526
SGTC_3067 9117431 49.47 µM -0.0163423728352089 0.498420636973193 no 1672 0.493480626706836 2447 17150885
SGTC_295 k015-0027 31 µM -0.0167665269559698 0.498589024689325 no 1673 0.493311436880735 2460 3887424
SGTC_1011 4112-3381 17.4 µM -0.0170819036675466 0.498714228315558 no 1674 0.493185637794302 2525 2877139
SGTC_2976 9009005 19.48 µM -0.0181753080510666 0.499148307539677 no 1675 0.492749500351852 2435 2993148
SGTC_522 1273-0010 11.6 µM -0.0196949429398244 0.499751600935145 no 1676 0.492143362474033 2569 5705015
SGTC_3041 9091929 49.47 µM -0.0201837878775061 0.499945672029969 no 1677 0.49194838032596 2452 25236887
SGTC_3075 9116269 49.47 µM -0.0204574808873484 0.499945672029969 no 1678 0.49183921515384 2457 17015205 YNL244C SUI1
SGTC_1939 st074455 53.6 µM -0.020500204811813 0.49992871066097 no 1679 0.491822174347674 2441 1644229
SGTC_2239 6685329 187.64 µM -0.0206115912411214 0.49988449032486 no 1680 0.491777746978855 2535 805680
SGTC_2110 5483698 200 µM -0.0208847452906721 0.499776048361483 no 1681 0.491668797732878 2456 2848765 YHR062C RPP1
SGTC_1507 4075-3230 155 µM -0.021079060647041 0.499698905312825 no 1682 0.491591294183582 2423 659771
SGTC_2549 cedrol 20.94 µM -0.0231533239503516 0.498875425640527 no 1683 0.490763985353341 2454 6708665 A sedative which affects the nervous system.
SGTC_46 0329-0187a 2.197 µM -0.0237615930252448 0.49863394440805 no 1684 0.490521387859349 2439 46494817
SGTC_2408 sulbentine 18.36 µM -0.0240400470209291 0.498523399061425 no 1685 0.490410332512351 2547 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0242005709033728 0.498459671643944 no 1686 0.490346311374815 2469 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_124 0136-0217 7.121 µM -0.024302555613592 0.498419184092529 no 1687 0.490305637324714 2463 3976905
SGTC_1240 0356-0016 42.1 µM -0.0252602603666944 0.498038979711582 no 1688 0.489923685720873 2476 4305613
SGTC_1089 terbinafine 2.25 µM -0.0274697516557103 0.497161829203597 no 1689 0.4890425327106 2456 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_860 0443-0016 25.1 µM -0.0274947665524804 0.497151898558638 no 1690 0.489032556978559 2454 5337942
SGTC_1009 4106-0057 9.87 µM -0.0277612064588805 0.497046124892342 no 1691 0.488926303394743 2442 2928005
SGTC_2999 9069765 71.4286 µM -0.028298290231118 0.496832909273653 no 1692 0.488712122126536 2470 2097066
SGTC_2991 9074669 71.4286 µM -0.0291472846593569 0.496495870849433 no 1693 0.48837356204804 2481 17333109
SGTC_1003 4049-0218 100 µM -0.0293312027721428 0.496422858358353 no 1694 0.488300220694508 2492 295161
SGTC_3138 9097216 49.47 µM -0.0306112285604743 0.495914712451037 no 1695 0.487789793625483 2449 25237486
SGTC_1929 genistein trimethyl ether 50.5 µM -0.030824484947332 0.495830054340903 no 1696 0.487704756765653 2463 136420
SGTC_1175 0741-0056 27.6 µM -0.0308927759106912 0.49580294436518 no 1697 0.487677525581608 2481 765927
SGTC_1648 st011736 69.8 µM -0.0308998851855337 0.495800122144157 no 1698 0.487674690744658 2472 2855514
SGTC_480 am 92016 50 µM -0.0319939184611962 0.495365818314381 no 1699 0.487238450390619 2504 2129 K+ channel blocker.
SGTC_389 tpck 16.7 µM -0.0321677100611447 0.495296827891005 no 1700 0.487169153242257 2478 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_932 2857-0803 154 µM -0.0330326438593878 0.49495347540279 no 1701 0.486824277901682 2627 674898
SGTC_2129 girgensonine 121.053 µM -0.0331953255974914 0.494888896096207 no 1702 0.486759412851357 2503 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_76 0433-0009 400.328 µM -0.0339116237727394 0.494604550864278 no 1703 0.486473812045024 2574 2841569
SGTC_1638 st008370 60.6 µM -0.0342296668692707 0.494478299789167 no 1704 0.486347004828196 2453 24207134
SGTC_2167 5876490 200 µM -0.0353724952187128 0.494024644831556 no 1705 0.485891358308924 2584 686534
SGTC_1511 0906-3109 28.5 µM -0.0355701485759166 0.493946185500036 no 1706 0.485812555618949 2459 2882180
SGTC_2177 5811945 192 µM -0.0360266014036421 0.49376499553007 no 1707 0.485630573932823 2498 5343475
SGTC_2329 6138490 200 µM -0.0361019427317528 0.493735088744199 no 1708 0.485600536631672 2627 720019
SGTC_278 4092-0821 23.9 µM -0.0372400266757331 0.493283330012246 no 1709 0.48514681203043 2506 877900
SGTC_3224 9130643 49.47 µM -0.0377071772163296 0.493097898580344 no 1710 0.484960576738478 2528 17644395
SGTC_640 3381-0960 37.1 µM -0.0383857564206235 0.492828545007039 no 1711 0.484690058671342 2507 1745025
SGTC_1364 1653-0028 37.6 µM -0.0386825791518117 0.492710725937214 no 1712 0.484571731418151 2521 5718652
SGTC_2415 st077333 57.7 µM -0.0388339051467218 0.492650659730569 no 1713 0.484511406407891 2483 2766255
SGTC_284 0988-0104 32.6 µM -0.0388919776533961 0.492627608909035 no 1714 0.484488256318372 2506 4666532
SGTC_1013 4112-3890 241 µM -0.0395287864784615 0.492374840901431 no 1715 0.484234401577833 2479 705171
SGTC_1156 4092-0367 4.88 µM -0.0413657212790285 0.491645725380553 no 1716 0.483502169925746 2496 1357585
SGTC_2636 apigenin dimethyl ether 100 µM -0.0420119689082677 0.491389223508808 no 1717 0.483244578366485 2544 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2081 5214970 32.255 µM -0.0450504984315096 0.490183251530023 no 1718 0.482033528928774 2485 2063512
SGTC_559 1550-0661 158 µM -0.0463943112142636 0.489649929219336 no 1719 0.481497985312931 2544 5830875
SGTC_683 panaxydol 45 µM -0.0464723483858032 0.489618958972904 no 1720 0.481466886529176 2554 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2933 9026794 32.47 µM -0.0494282585535333 0.488445908537407 no 1721 0.480289004305194 2527 17586027
SGTC_2685 mycophenolic acid 18.85 µM -0.0495156575680713 0.48841122578414 no 1722 0.480254179785191 2531 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_606 k015-0008 38.6 µM -0.0499551650100756 0.488236816362254 no 1723 0.480079058410519 2525 1970475
SGTC_739 1486-1183 203 µM -0.0505527950455629 0.4879996628809 no 1724 0.479840939395107 2480 4346692
SGTC_2273 7815444 169.05 µM -0.0512761210389839 0.487712636006943 no 1725 0.479552747859146 2491 2824616
SGTC_2790 5423970 71.43 µM -0.0523230980400334 0.487297190749781 no 1726 0.479135624474041 2556 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_679 0422-0091 41.4 µM -0.0532319092685505 0.486936581462085 no 1727 0.478773565864603 2496 627384 YHR062C RPP1
SGTC_160 3453-0671 289.699 µM -0.0537031175559913 0.48674961383311 no 1728 0.478585849468928 2518 5322268
SGTC_3324 9138759 60.749 µM -0.0539475022173833 0.486652647199257 no 1729 0.478488495222859 2580 45595710
SGTC_141 0443-0274 32.331 µM -0.0542987635668872 0.486513275553278 no 1730 0.478348567316305 2499 1627241
SGTC_3199 9111318 49.47 µM -0.0545074891364682 0.486430459289693 no 1731 0.478265420996925 2543 8548020
SGTC_917 harmaline 728.087 nM -0.0562761135375936 0.485728744172293 no 1732 0.477560923653871 2563 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1219 1469-0211 33.1 µM -0.0566594219641523 0.485576669404335 no 1733 0.477408249320514 2506 6822282
SGTC_758 0868-0029 16 µM -0.0567599268708255 0.485536795176179 no 1734 0.477368218085621 2507 762687
SGTC_1422 4031-0024 15.5 µM -0.0571593232465094 0.485378340442953 no 1735 0.477209140251174 2502 782427
SGTC_1581 himbacine 57.9 µM -0.0574882843462655 0.485247831619112 no 1736 0.477078119206193 2499 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1717 st033143 58.0435 µM -0.0575228725464832 0.485234109524886 no 1737 0.477064343307267 2526 674616
SGTC_3055 9094636 49.47 µM -0.0575293184159996 0.485231552272369 no 1738 0.477061776028784 2550 25236176
SGTC_1700 st030840 7.9285 µM -0.0582404069060108 0.484949447796741 no 1739 0.476778567635773 2592 5499307
SGTC_3200 9114385 49.47 µM -0.0589409586557719 0.484671530843645 no 1740 0.476499567225908 2564 17018030 YLR208W SEC13
SGTC_2864 9034755 47.6 µM -0.0596526372734366 0.484389207358911 no 1741 0.476216147247428 2511 4930451
SGTC_275 trichlorophene 5.69 µM -0.0600745116638481 0.484221853131589 no 1742 0.476048145017565 2599 62616
SGTC_2745 rifampicin 24.3 µM -0.0605767991883636 0.484022603278276 no 1743 0.47584812557439 2542 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3150 9097574 49.47 µM -0.0620083953236578 0.483454732832982 no 1744 0.475278073183869 2535 17217476
SGTC_2747 doxorubicin 7.63 µM -0.0624490688821125 0.483279937798648 no 1745 0.475102609933343 2501 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1508 1080-0625 72.9 µM -0.062499794075137 0.483259817641489 no 1746 0.475082412962591 2490 767111
SGTC_1571 st070080 73.4 µM -0.0625537030002289 0.483238434703146 no 1747 0.475060948412961 2571 4315245
SGTC_3056 9094900 49.47 µM -0.0629562340646786 0.483078772559316 no 1748 0.474900677652211 2557 25236784
SGTC_1520 flindersine 88 µM -0.0638843763296989 0.482710639470915 no 1749 0.474531146373835 2722 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3177 9107506 49.47 µM -0.0640586891388423 0.48264150266072 no 1750 0.474461747771647 2528 8897194
SGTC_199 4063-0024 41.6 µM -0.0641449089155736 0.482607305938415 no 1751 0.474427421653516 2611 306215
SGTC_1747 st037496 66.6 µM -0.0642158941222862 0.482579151688728 no 1752 0.474399160917996 2539 723305
SGTC_2091 4-phenylthiadiazole 200 µM -0.0652523846028293 0.482168067385527 no 1753 0.473986526540884 2552 270010
SGTC_1131 3454-3128 32.3 µM -0.0658697235264946 0.481923232495304 no 1754 0.473740772670743 2713 710982
SGTC_1957 st077035 62.4 µM -0.0660979198020357 0.48183273221167 no 1755 0.47364993349454 2539 705593
SGTC_2814 7977482 42.97 µM -0.0663713632692433 0.481724288593065 no 1756 0.473541084358654 2575 6456762
SGTC_1160 4092-0570 10.5 µM -0.0671073018810501 0.481432433007691 no 1757 0.473248140470564 2522 4994975
SGTC_1271 0832-2808 169 µM -0.0675004536039705 0.48127652254116 no 1758 0.473091650463521 2578 3663794
SGTC_228 caffeine 993.056 µM -0.0680714014806314 0.481050109334009 no 1759 0.472864397923894 2532 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_94 0334-0113 514.748 µM -0.0689485709099389 0.48070227385275 no 1760 0.472515278242025 2537 6795178
SGTC_2738 aclarubicin 5.55 µM -0.0708238051197148 0.479958712288964 no 1761 0.471768992824809 2603 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_530 4358-1714 28 µM -0.0709033778521891 0.479927161900656 no 1762 0.471737327503421 2649 1564641
SGTC_612 0302-0167 22.4 µM -0.0709036182892181 0.479927066568169 no 1763 0.471737231823733 2582 235821
SGTC_234 nsc-17383 10.7 µM -0.0758207458752064 0.477977689614572 no 1764 0.46978085540553 2558 408974
SGTC_1049 3226-0134 66 µM -0.0775600051028021 0.477288290469882 no 1765 0.469089028903246 2509 5702385
SGTC_775 4577-0580 57.3 µM -0.0778072026414222 0.477190312975702 no 1766 0.468990708470996 2738 2006902
SGTC_1727 st034309 9.9045 µM -0.0778605000020231 0.477169188585658 no 1767 0.468969510208455 2810 870305
SGTC_976 1348-1067 47.6 µM -0.0781348527082637 0.477060450003834 no 1768 0.468860391738473 2551 5310671 YGL099W LSG1
SGTC_214 4373-3496 70 µM -0.0793316193905341 0.476586136466808 no 1769 0.468384428455769 2576 3779166
SGTC_1695 st026914 34.495 µM -0.0793494092408926 0.476579086078855 no 1770 0.468377353635085 2538 3289191
SGTC_1288 0973-0013 65.5 µM -0.0803157010573311 0.476196141026016 no 1771 0.467993085458365 2620 4315430
SGTC_96 0929-0093 37.281 µM -0.0805169149329589 0.476116401970031 no 1772 0.467913071870063 2538 6991579
SGTC_3137 9097352 49.47 µM -0.0812179357273615 0.475838601898601 no 1773 0.467634317994311 2668 44120435
SGTC_1755 st041960 45.185 µM -0.0815460821097403 0.475708568287427 no 1774 0.46750383932717 2638 2257073
SGTC_3186 9110464 49.47 µM -0.082362929577677 0.475384889785685 no 1775 0.467179056885365 2636 17018021
SGTC_851 0394-0702 453 µM -0.08268269186057 0.475258187339315 no 1776 0.467051923818414 2556 762646
SGTC_3188 9110789 49.47 µM -0.0828213072033359 0.475203263242157 no 1777 0.466996813316349 2619 849217
SGTC_3049 9092223 49.47 µM -0.0828236918397874 0.475202318372488 no 1778 0.46699586524132 2641 8623917
SGTC_1132 3456-3614 2.5 µM -0.083131567196809 0.475080329425782 no 1779 0.466873462858736 2703 3125502
SGTC_126 0417-1624 672.48 µM -0.0837809703340099 0.474823025162408 no 1780 0.466615289145485 2555 41912 YDL195W SEC31
SGTC_2380 9035439 200 µM -0.0841583317445291 0.474673513147292 no 1781 0.466465273530799 2688 6462575
SGTC_2327 6189656 200 µM -0.0849427235662116 0.474362745583318 no 1782 0.466153463005215 2626 5349088
SGTC_72 0744-0168 198.391 µM -0.0857263487489355 0.474052297329545 no 1783 0.465841977977287 2606 677577
SGTC_702 1488-0190 94 µM -0.0864574741349105 0.473762662089119 no 1784 0.465551380082204 2596 949357
SGTC_2799 7812892 81.82 µM -0.0870837180813367 0.473514586640672 no 1785 0.465302483651654 2610 20205235
SGTC_3214 9129694 49.47 µM -0.0872907230347335 0.473432587548452 no 1786 0.465220213909935 2597 17158655
SGTC_1753 st043925 64 µM -0.0873335609829198 0.473415618660855 no 1787 0.465203189058746 2570 670181
SGTC_360 0957-0399 1.01 µM -0.0878243507262166 0.47322121139923 no 1788 0.465008141731143 2655 6752301 YPR165W RHO1
SGTC_1963 st076565 50.3 µM -0.0878301516494635 0.47321891362723 no 1789 0.46500583640597 2572 4914280
SGTC_2959 9079155 11 µM -0.0878679393398438 0.47320394577355 no 1790 0.464990819357241 2683 16189457
SGTC_2751 anetholtrithion 17.25 µM -0.0891309173224328 0.47270369709232 no 1791 0.464488933350343 2636 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3129 9127257 49.47 µM -0.0892889445602771 0.472641107631822 no 1792 0.464426139969366 2588 837894
SGTC_3014 9081533 49.47 µM -0.0896343214217217 0.472504317419098 no 1793 0.464288904810442 2609 21367265
SGTC_2906 7926292 26.41 µM -0.0899995993644416 0.472359648698359 no 1794 0.46414376659929 2648 2966319
SGTC_193 1273-0060 1.558 µM -0.0902207541980731 0.472272061860351 no 1795 0.464055896058522 2557 2847393 YHR072W ERG7
SGTC_1291 0993-0025 5.79 µM -0.0905742364282881 0.472132070460697 no 1796 0.46391545205976 2640 4353356
SGTC_1624 st003710 6.25 µM -0.0912984862984062 0.471845252802728 no 1797 0.463627710362976 2582 24207033
SGTC_2994 9053520 71.4286 µM -0.0922237739008688 0.471478841381766 no 1798 0.463260124846421 2633 4647384
SGTC_3015 9080845 49.47 µM -0.0929531581121024 0.471190024180153 no 1799 0.462970387223557 2660 5296973
SGTC_2659 sanguinarine 24.21 µM -0.0939740960203706 0.4707857847684 no 1800 0.46256486701817 2572 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2700 st077718 96.8 µM -0.0941578692355048 0.470713023120136 no 1801 0.462491875756426 2627 904970
SGTC_527 4476-4215 268 µM -0.0951217552200453 0.470331406136749 no 1802 0.462109059128711 2589 4418754
SGTC_1468 k284-1086 134 µM -0.0954140841573327 0.470215674074841 no 1803 0.461992964788203 2595 15996457
SGTC_1115 galangin 695.678 nM -0.0968879438879632 0.469632216387346 no 1804 0.461407691572146 2576 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2313 7726885 200 µM -0.0972716238821866 0.469480339415647 no 1805 0.461255344989341 2664 726423
SGTC_2206 7254556 146.969 µM -0.0973575743422751 0.46944631715097 no 1806 0.461221217694966 2622 4398905
SGTC_1524 corynanthine 62.1 µM -0.0976862597304085 0.469316213784318 no 1807 0.461090713257943 2774 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1136 pergolide 1.05886 µM -0.0986296771319128 0.468942799608933 no 1808 0.460716152977344 2604 47811 A dopamine receptor agonist.
SGTC_565 1418-0001 44.5 µM -0.102166304191194 0.46754321257399 no 1809 0.459312336563825 2683 2862145
SGTC_962 1254-0300 21.5 µM -0.103244343119175 0.467116667743163 no 1810 0.458884523604456 2577 7340576
SGTC_694 1315-0438 43.2 µM -0.103547602127996 0.466996684831575 no 1811 0.45876418573631 2635 6793154
SGTC_1649 st011737 51.3 µM -0.103614097903279 0.466970376510825 no 1812 0.458737799688288 2634 1761035
SGTC_1227 3909-8010 46.6 µM -0.104087070703241 0.466783254204429 no 1813 0.458550125603453 2613 15982272
SGTC_3197 9113331 49.47 µM -0.104792740963245 0.46650408342417 no 1814 0.458270135103493 2704 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1378 2093-0007 380 nM -0.104905977266719 0.466459287449662 no 1815 0.458225207984962 2668 3618014
SGTC_2692 st077426 47.7 µM -0.10534376915457 0.466286102168231 no 1816 0.458051516700708 2629 25238571
SGTC_156 3474-0145 5.642 µM -0.105556163599053 0.466202083741372 no 1817 0.457967253372895 2571 2265471
SGTC_1640 st009078 66.4 µM -0.10645363914085 0.465847079437949 no 1818 0.457611218464774 2653 690618
SGTC_801 0866-0028 10.1 µM -0.107412083537567 0.465467988384304 no 1819 0.457231034345183 2583 6849771
SGTC_259 usnic acid 108.925 µM -0.107870028874734 0.465286869481448 no 1820 0.45704939592921 2768 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.107964590435465 0.465249470964397 no 1821 0.457011890359323 2648 4330530
SGTC_2343 7990716 14.84 µM -0.108033497502247 0.465222218835596 no 1822 0.456984560268902 2617 6456862
SGTC_3024 9090631 49.47 µM -0.108226644981222 0.465145831604416 no 1823 0.45690795472522 2590 25236383
SGTC_813 k007-0158 173 µM -0.108238844946727 0.465141006725175 no 1824 0.456903116067133 2667 6523916
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.108499779522583 0.465037812758408 no 1825 0.456799627699252 2592 688803
SGTC_3215 9129942 49.47 µM -0.110408289766409 0.464283110273781 no 1826 0.456042789520829 2642 17682944
SGTC_2398 5228213 48.84 µM -0.110701118448278 0.46416732521868 no 1827 0.455926679519805 2631 80771 YMR134W ERG29
SGTC_2827 7993847 71.43 µM -0.111343915216518 0.463913172727348 no 1828 0.45567181628775 2680 2985692
SGTC_3141 9094609 49.47 µM -0.111454791867107 0.463869335198826 no 1829 0.455627856518266 2597 25236309 YDL196W YDL196W
SGTC_1619 st003326 88.7 µM -0.112837874128253 0.463322540165386 no 1830 0.455079545433832 2724 2849032
SGTC_1821 st053465 65.6 µM -0.113543078726105 0.463043767465867 no 1831 0.454800005998577 2697 675086
SGTC_256 clotrimazole 625 nM -0.113910226588079 0.462898638320375 no 1832 0.454654479346435 2588 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.113954264322607 0.462881231063504 no 1833 0.45463702448752 2579 91467 include heat shock
SGTC_1286 0929-0070 131 µM -0.113976671329023 0.462872374038521 no 1834 0.454628143248299 2707 1420408
SGTC_2725 haloperidol 53.21 µM -0.114685171061573 0.462592328301604 no 1835 0.454347334072763 2607 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_560 2332-1943 155 µM -0.115242248482058 0.462372147644276 no 1836 0.454126556143247 2601 21177716
SGTC_4 0960-0234 25.671 µM -0.115342947993321 0.462332348148878 no 1837 0.454086648964703 2661 6821112
SGTC_255 tunicamycin 200.472 nM -0.115516280124103 0.462263842926859 no 1838 0.454017958592092 2709 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3042 9091578 49.47 µM -0.118165612217499 0.461216900689087 no 1839 0.452968218247227 2592 25236497
SGTC_2062 5245942 200 µM -0.118408258959101 0.46112102678025 no 1840 0.452872091057056 2592 1376160
SGTC_2691 st077356 60.2 µM -0.118742203528069 0.460989083222671 no 1841 0.452739799740097 2747 2839272
SGTC_85 0868-0259 160.055 µM -0.121013262421018 0.460091888505992 no 1842 0.451840265252127 2693 83173
SGTC_3244 9134489 49.47 µM -0.121505762977897 0.459897350011798 no 1843 0.451645225164803 2703 16584271
SGTC_1805 st050013 60.3 µM -0.121626858341824 0.45984951862133 no 1844 0.451597270760502 2690 4037144
SGTC_3179 9107801 49.47 µM -0.121742009494018 0.459804035670731 no 1845 0.451551670950597 2644 4818259
SGTC_2496 diffractaic acid 79.83 µM -0.123781141995324 0.458998697081014 no 1846 0.450744281739461 2811 94870 An apoptosis inducer which activates caspases.
SGTC_671 0560-0003 407 µM -0.123922826677508 0.458942746095484 no 1847 0.450688189590838 2712 3238678
SGTC_276 colchicine 750 µM -0.124821905108695 0.458587720898863 no 1848 0.450332272624045 2742 2833 A microtubule depolymerizer.
SGTC_2309 7664088 163.95 µM -0.125418235239814 0.458352262178577 no 1849 0.450096226232224 2660 704922
SGTC_1798 st045719 60.953 µM -0.127067432589684 0.45770115911902 no 1850 0.449443513754447 2621 3980186
SGTC_2777 climbazole 1.536 µM -0.127213007913373 0.457643691412259 no 1851 0.449385905101029 2642 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2468 5987765 72.9 µM -0.129169500900142 0.456871427380232 no 1852 0.448611764379262 2705 26772094
SGTC_3328 9140624 29.0385 µM -0.129276972264275 0.456829011133509 no 1853 0.448569245994042 2775 4904392
SGTC_417 st075190 100 µM -0.129377461969862 0.456789350816921 no 1854 0.448529490263625 2715 222757
SGTC_880 0833-0487 87.2 µM -0.130844324418463 0.456210472764299 no 1855 0.447949229284464 2639 76075
SGTC_223 busulfan 5 mM -0.131455529371798 0.455969296092998 no 1856 0.447707481820989 2737 2478 A DNA alkylator.
SGTC_1910 st062352 60.4 µM -0.132133188470349 0.455701916106064 no 1857 0.447439472722782 2605 2245730
SGTC_3116 9124943 49.47 µM -0.133963665661014 0.454979776052791 no 1858 0.446715653000177 2651 41905195 YPL160W CDC60
SGTC_3301 9125354 19.7965 µM -0.134029474531939 0.454953816604967 no 1859 0.446689633700135 2647 41905162
SGTC_2822 7994718 71.43 µM -0.134072450063373 0.454936864266812 no 1860 0.446672642296395 2618 1018011
SGTC_449 xestospongin c 11.1929 µM -0.136343461552269 0.454041147483575 no 1861 0.445774883652711 2758 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_321 4534-3890 65.3 µM -0.137600792585686 0.453545339812872 no 1862 0.445277964547713 2759 699746
SGTC_487 nimodipine 119 µM -0.139955350050502 0.452617054397151 no 1863 0.444347634289496 2640 4497 L-type voltage-gated calcium channels inhibitor
SGTC_983 1491-0821 12.2 µM -0.140644779957926 0.452345295103581 no 1864 0.444075285263312 2786 46495113
SGTC_3135 9127742 49.47 µM -0.140883569067006 0.452251174476079 no 1865 0.443980961329573 2743 3643468
SGTC_1540 guanosine 70.6 µM -0.140922243269719 0.452235930983677 no 1866 0.443965684955856 2631 6802 Guanosine is a purine nucleoside
SGTC_1652 st011932 78 µM -0.141013686463332 0.452199888798006 no 1867 0.443929565075087 2682 1551076
SGTC_2888 9058547 12.99 µM -0.141317041877866 0.45208032457855 no 1868 0.443809743622893 2681 16476514
SGTC_2294 7971431 200 µM -0.141543502946707 0.451991070257124 no 1869 0.443720297787372 2765 5741572
SGTC_519 k048-0011 62.8 µM -0.14170534688459 0.451927284749471 no 1870 0.443656375681179 2787 6836379
SGTC_1810 st050138 53 µM -0.141724388850086 0.451919780061608 no 1871 0.44364885493643 2650 3444541
SGTC_2186 6124449 200 µM -0.142557621820721 0.451591408901803 no 1872 0.443319784215319 2782 3834182 YLR033W RSC58
SGTC_864 0469-0573 172 µM -0.143091253668852 0.451381125786619 no 1873 0.443109056210885 2648 689425
SGTC_1365 1672-3266 55.4 µM -0.143274908196591 0.451308757984636 no 1874 0.443036535862184 2719 6415873
SGTC_1358 1509-0022 2.48 µM -0.143317948966786 0.451291798299502 no 1875 0.443019540468559 2699 3258434
SGTC_1432 4049-0298 68.4 µM -0.143400559228657 0.45125924699288 no 1876 0.442986920669499 2747 741646
SGTC_1790 st045711 43.5 µM -0.143974034133121 0.451033287049408 no 1877 0.442760486873498 2689 585119
SGTC_595 3909-8003 73.7 µM -0.144508593099327 0.450822675007609 no 1878 0.442549435681205 2751 699517
SGTC_655 k060-0012 42 µM -0.144564312078756 0.450800722962322 no 1879 0.442527438003118 2677 5994525
SGTC_84 0443-0269 128.823 µM -0.145686929309236 0.450358468759126 no 1880 0.44208427008601 2667 6150058
SGTC_1054 3429-0080 167 µM -0.145803630037139 0.450312498123436 no 1881 0.442038205087988 2767 1162877
SGTC_3094 9117742 49.47 µM -0.146193691860268 0.450158850195943 no 1882 0.441884242613049 2653 17149698
SGTC_2070 5230947 200 µM -0.146417507440831 0.450070691132572 no 1883 0.441795903654921 2709 2835538
SGTC_1625 st003711 30.1 µM -0.146520439223163 0.450030148001322 no 1884 0.441755277935568 2819 24207034 YER133W GLC7
SGTC_2789 5281112 71.43 µM -0.146536957006606 0.450023641967427 no 1885 0.441748758656992 2722 765948
SGTC_355 1311-2252 105 µM -0.14690772558786 0.449877606966599 no 1886 0.441602426975483 2694 5338538
SGTC_380 3970-0968 6 µM -0.14831190393128 0.449324603496772 no 1887 0.441048310638381 2683 2891601
SGTC_1467 k284-1082 293 µM -0.148319497904792 0.449321613050884 no 1888 0.441045314220106 2757 3334705
SGTC_2704 st078022 71.1 µM -0.148342462146686 0.449312569934044 no 1889 0.441036253045738 2799 54697681
SGTC_1691 st019933 84.6 µM -0.149270894889011 0.448946983371683 no 1890 0.440669940228912 2651 6176082
SGTC_2584 androsterone 48.74 µM -0.150802050080938 0.448344159170113 no 1891 0.440065934515808 2727 2754130 A steroid.
SGTC_978 1416-0512 87.4 µM -0.151079114975983 0.448235089902404 no 1892 0.439956653609325 2709 6814003
SGTC_2495 cafestol 54.53 µM -0.153461026072349 0.447297589899624 no 1893 0.439017361445115 2889 16667697 An anti-infammatory.
SGTC_751 0833-0568 350 µM -0.154879789299533 0.446739316286976 no 1894 0.438458043586326 2747 6954252
SGTC_2353 9059630 146.67 µM -0.156603815544707 0.446061065908807 no 1895 0.437778547641312 2789 4779114
SGTC_1224 0823-0416 294 µM -0.156693481208882 0.446025794776585 no 1896 0.437743212429179 2796 3598164
SGTC_2140 5586273 200 µM -0.158596977503992 0.445277131450801 no 1897 0.436993205129138 2674 854421
SGTC_2151 5563267 85.4165 µM -0.158985290564374 0.445124428080366 no 1898 0.436840231427868 2727 5310824
SGTC_2970 9090938 41.86 µM -0.15994783422259 0.44474594477588 no 1899 0.436461083643582 2887 17217104
SGTC_1138 3761-0006 1.03 µM -0.160574164924578 0.444499691326399 no 1900 0.436214402110141 2675 12061087
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.161145876354641 0.444274931147562 no 1901 0.43598925413539 2692 2724 A muscle relaxant with antifungal properties.
SGTC_3268 9137683 49.47 µM -0.161364557587538 0.444188964479913 no 1902 0.435903139880972 2667 1953228
SGTC_700 3453-2283 142 µM -0.162064660887425 0.443913761707107 no 1903 0.435627467389806 2856 565664
SGTC_2305 7443522 69.23 µM -0.16212631802155 0.443889526271441 no 1904 0.435603190789514 2706 5415886
SGTC_2733 amorolfine 100 µM -0.163110607358255 0.443502662275378 no 1905 0.435215674091122 2705 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1404 3909-7820 48.3 µM -0.164727929808045 0.442867108726844 no 1906 0.434579066238842 2737 23741373
SGTC_537 1334-0398 209 µM -0.165555463569608 0.442541972417494 no 1907 0.434253399216689 2713 5846986
SGTC_196 k015-0023 18.111 µM -0.165595126492361 0.442526389906924 no 1908 0.434237791418189 2698 5211998
SGTC_2402 5553605 200 µM -0.166893192825927 0.442016463277434 no 1909 0.433727044684465 2876 6758546
SGTC_863 0466-0191 129 µM -0.16933563250922 0.441057247191793 no 1910 0.432766324989029 2764 765160 YPR165W RHO1
SGTC_1180 1193-0155 285 µM -0.169709570828887 0.44091042126676 no 1911 0.43261927341514 2840 2921347
SGTC_1104 tacrolimus 29.8 µM -0.170140609776467 0.440741185004616 no 1912 0.432449778548211 2693 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_886 0866-0150 153 µM -0.172370915569645 0.439865686836028 no 1913 0.431572967971016 2898 271463
SGTC_835 0312-0010 67.2 µM -0.173314722425041 0.439495287272894 no 1914 0.43120202599421 2709 1626196
SGTC_620 0109-0052 432 µM -0.173724587327273 0.43933445115392 no 1915 0.431040956723818 2784 493037
SGTC_1144 3486-0183 12.5 µM -0.175676033954205 0.438568816858041 no 1916 0.430274232296664 2739 6744069
SGTC_1064 honokiol 6.76 µM -0.175758625099204 0.43853641793996 no 1917 0.430241787968272 2791 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2594 a-mangostin 100 µM -0.175992372323322 0.438444725631685 no 1918 0.430149967461157 2878 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2766 oltipraz 83.91 µM -0.176363774893264 0.43829904189078 no 1919 0.430004080997512 2838 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1451 4152-0210 104 µM -0.176465318002672 0.438259212764665 no 1920 0.429964196654075 2866 659563
SGTC_247 mechlorethamine 29.705 µM -0.176832439952141 0.438115218589198 no 1921 0.42982000358942 2711 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_334 1502-1024 68.5 µM -0.177863683348818 0.437710783688674 no 1922 0.429415016256127 2830 3296216
SGTC_810 3825-7150 143 µM -0.178949561147164 0.437284992502301 no 1923 0.428988653328049 2888 22330411 YGL099W LSG1
SGTC_1766 st045414 44.774 µM -0.179064203920149 0.437240043347694 no 1924 0.428943644407428 2720 253960
SGTC_2532 xanthone 78.9 µM -0.180336656336325 0.436741194546909 no 1925 0.428444139894483 2841 7020 An insecticide.
SGTC_3045 9092950 49.47 µM -0.180679581411697 0.436606772300973 no 1926 0.428309543335015 2760 44120432
SGTC_2218 6965428 192.983 µM -0.180681952872556 0.436605842744098 no 1927 0.428308612576243 2717 675684
SGTC_2029 5175081 200 µM -0.181142157671268 0.436425459919785 no 1928 0.428127997434755 2723 1380876
SGTC_1033 k072-0102 21.3 µM -0.181911245729919 0.436124036100285 no 1929 0.427826189467593 2866 5965931
SGTC_2263 7948595 193.29 µM -0.182581904002667 0.435861219514998 no 1930 0.427563042084202 2719 2971371
SGTC_19 0279-0214 38.434 µM -0.183766277320276 0.435397158267758 no 1931 0.427098406176664 2709 3566274 YBR002C RER2
SGTC_840 0245-0196 390 µM -0.184574399124667 0.435080570933204 no 1932 0.426781433721163 2862 3827528
SGTC_1470 k295-0292 231 µM -0.184671399265559 0.435042573246909 no 1933 0.426743390188898 2831 5045612
SGTC_3269 9137823 49.47 µM -0.185187546421228 0.43484039397026 no 1934 0.426540968333796 2737 17682936
SGTC_670 4204-0025 119 µM -0.185219115486875 0.434828028648287 no 1935 0.426528588250002 2846 719039
SGTC_1094 duloxetine 25.4 µM -0.187018774985048 0.434123223805992 no 1936 0.425822956173227 2724 60834 A selective serotonin reuptake inhibitor.
SGTC_2450 5739737 12.93 µM -0.187021441819888 0.434122179542054 no 1937 0.425821910704296 2816 2262825
SGTC_1372 2752-0194 270 µM -0.18938018757881 0.43319873621543 no 1938 0.424897425757165 2722 823334
SGTC_699 0375-0592 111 µM -0.190390625210488 0.432803263553786 no 1939 0.424501521658559 2784 762578
SGTC_2896 9052656 71.43 µM -0.190417334162181 0.432792810915066 no 1940 0.424491057735857 2794 6469436
SGTC_2405 ticlatone 3.52 µM -0.190463347780475 0.432774803439976 no 1941 0.424473030835483 2644 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2943 9068529 45.32 µM -0.19062996968927 0.432709596959306 no 1942 0.424407754166839 2728 3270634
SGTC_1676 st018489 23.4 µM -0.190810469902907 0.432638961355326 no 1943 0.4243370428007 2803 3696235
SGTC_1502 4534-4282 27.7 µM -0.191181534634451 0.432493758421274 no 1944 0.424191685006277 2770 3278949
SGTC_1225 1216-0074 20.6 µM -0.191458665011714 0.432385319288517 no 1945 0.424083130995435 2767 4241466
SGTC_1985 st071382 65.5 µM -0.191715648865765 0.432284767896906 no 1946 0.423982473672788 2750 6123237
SGTC_2225 6654152 15.4 µM -0.191764988215321 0.432265463138011 no 1947 0.423963148641376 2738 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2401 5128683 200 µM -0.192157618263392 0.432111846523237 no 1948 0.423809371456286 2786 708373
SGTC_2940 9060638 45.86 µM -0.194330222794735 0.431262000543201 no 1949 0.422958661160417 2856 4027022
SGTC_3356 9151811 4.48 µM -0.196576998090509 0.430383476213228 no 1950 0.422079286120832 2740 1859254 YPR165W RHO1
SGTC_154 3389-1638 511.116 µM -0.200870506615551 0.428705608784974 no 1951 0.420399914982598 2863 5238686
SGTC_476 mead acid 10 µM -0.202992981364079 0.427876637024405 no 1952 0.419570259035568 2764 5312531 An omega 9 fatty acid.
SGTC_3107 9121808 49.47 µM -0.203687379344102 0.427605495965091 no 1953 0.419298902635176 2755 662681
SGTC_3236 9132701 49.47 µM -0.203697528985992 0.427601533095212 no 1954 0.419294936648851 2800 24282524
SGTC_732 3970-1727 52.7 µM -0.20391534486935 0.427516489884883 no 1955 0.419209826773986 2881 1275699
SGTC_2465 5809242 33.21 µM -0.204324580842956 0.427356718448682 no 1956 0.419049931202691 2746 2731748
SGTC_112 phenothiazine 287.218 µM -0.205850251851993 0.426761180396038 no 1957 0.418453943193587 2761 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2120 5538279 151.968 µM -0.206498576805064 0.426508160447967 no 1958 0.418200738165835 2795 2058197
SGTC_2544 sphondin 68.51 µM -0.206834691618358 0.426376997766187 no 1959 0.41806948097054 3003 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_319 1348-1596 45.5 µM -0.207026141283533 0.426302291661535 no 1960 0.417994721470447 2974 5380505
SGTC_2502 avocadyne acetate 18.59 µM -0.20756105273811 0.426093576403772 no 1961 0.417785858714649 2714 3952079
SGTC_1248 0469-0687 58.6 µM -0.208321183678487 0.425797019152852 no 1962 0.417489096142759 2882 4017482
SGTC_585 0kpi-0023 191 µM -0.210854225403326 0.424809082877944 no 1963 0.416500511930834 2917 64601
SGTC_916 4466-0038 42 nM -0.211608270766053 0.424515081206543 no 1964 0.416206328157024 2924 5722064 YGL116W CDC20
SGTC_2197 6588183 93.1375 µM -0.211850198139326 0.424420762811079 no 1965 0.416111952383787 2794 884136
SGTC_2342 7990637 118.86 µM -0.211917090504767 0.424394684753953 no 1966 0.416085858551673 2893 2033102 YER133W GLC7
SGTC_735 3076-0345 636 µM -0.213044760876425 0.423955111214088 no 1967 0.415646024935667 2931 2888990
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.213234770750674 0.423881053377335 no 1968 0.415571924365561 2761 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2648 atorvastatin 78.68 µM -0.213773442258917 0.423671116559387 no 1969 0.415361868107166 2882 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1118 chelidonine 707.474 nM -0.21521628257014 0.423108904295002 no 1970 0.41479934835453 2881 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1848 st056003 16.4 µM -0.215819435083583 0.422873928263608 no 1971 0.414564249150987 2777 146492
SGTC_1793 st048256 72.231 µM -0.216120841411286 0.422756516724696 no 1972 0.41444677724662 2759 672022
SGTC_1912 st060209 90.8 µM -0.218235926959285 0.421932787837153 no 1973 0.413622646984265 2863 688787
SGTC_2497 7-hydroxyflavone 100 µM -0.218419131919723 0.421861453917362 no 1974 0.413551280129762 2973 5281894
SGTC_2456 5770359 74.46 µM -0.220336151523998 0.421115184421625 no 1975 0.412804683527345 2952 3118787
SGTC_1435 4092-0789 56.7 µM -0.220754773122467 0.420952258360565 no 1976 0.412641690289396 2883 2248285
SGTC_1278 0874-0585 172 µM -0.220968437702073 0.420869106070174 no 1977 0.412558504299666 2858 766306
SGTC_2254 7938975 95.19 µM -0.221204005381488 0.420777433796361 no 1978 0.412466795332354 3003 2969277
SGTC_2695 st077686 51.995 µM -0.221623796206478 0.42061408086816 no 1979 0.412303378211854 2851 2876092
SGTC_3009 9080819 71.4286 µM -0.222998821929663 0.420079113872755 no 1980 0.411768211691997 2869 17027216
SGTC_1986 st071812 45 µM -0.224298050713886 0.419573772027828 no 1981 0.411262696438562 2819 11838594
SGTC_2414 st077232 92.9 µM -0.225167492862205 0.419235671958401 no 1982 0.410924488528572 2778 729801
SGTC_1659 st012954 42.1 µM -0.228860673494276 0.417800171870115 no 1983 0.409488603681318 2951 24207262
SGTC_783 0848-0141 92.7 µM -0.229416850265189 0.417584086229373 no 1984 0.409272470381634 2787 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2103 5378138 10 µM -0.231201016839239 0.416891070603726 no 1985 0.408579320040147 2809 244142
SGTC_2290 7904846 200 µM -0.231343649331545 0.416835679636525 no 1986 0.40852391949919 2894 2962154
SGTC_346 4513-0042 7.16 µM -0.232199399718824 0.416503385845049 no 1987 0.408191571985951 2819 2827372
SGTC_2100 5377183 190 µM -0.232354630085975 0.416443115206118 no 1988 0.40813129228497 2911 2844202
SGTC_1332 1480-0653 17.5 µM -0.232415904070023 0.416419325155842 no 1989 0.408107498715364 2922 5749438
SGTC_1888 azatryptophan 97.5 µM -0.233451297067979 0.416017372991599 no 1990 0.407705492023378 2924 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1200 1643-0193 18.4 µM -0.233992880767663 0.415807158567097 no 1991 0.40749525279347 2821 5403974
SGTC_879 0831-1030 162 µM -0.234242407666616 0.415710313397368 no 1992 0.407398397054004 2841 1549252
SGTC_2015 5119600 184 µM -0.234292288372161 0.415690954553633 no 1993 0.407379036162355 3003 2828786
SGTC_1984 st072354 53.1 µM -0.236735759675383 0.414742887788103 no 1994 0.406430895587875 2807 5762938
SGTC_1494 4358-1428 177 µM -0.238044461293356 0.414235315380999 no 1995 0.405923305016601 2964 1564571
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.239129637142031 0.413814544725376 no 1996 0.405502530602809 2810 6708784 An antioxidant flavonoid
SGTC_1954 st077032 68.9 µM -0.240253745154038 0.413378782669996 no 1997 0.405066775460364 2898 698907
SGTC_1315 1237-0019 3.69 µM -0.242056921439823 0.41268000185733 no 1998 0.404368028703008 2935 825140
SGTC_947 3447-0010 211 µM -0.242158001254726 0.412640838794093 no 1999 0.404328868386256 2802 748350
SGTC_2417 cerulenin 830 nM -0.244080185119421 0.411896260509396 no 2000 0.403584359250252 2875 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_456 gingerol 170 µM -0.247637654312149 0.410519075490088 no 2001 0.402207387012302 3024 442793 A herb.
SGTC_59 0330-0160 1.33 µM -0.247864851325186 0.410431159139767 no 2002 0.402119487991646 2865 4293482
SGTC_2771 fluoxetine 41.05 µM -0.247952921474827 0.410397080649649 no 2003 0.402085416339934 3035 3386 A selective serotonin reuptake inhibitor.
SGTC_2232 chlorophetanol 41.5365 µM -0.248710624619043 0.410103917580537 no 2004 0.401792314891873 2865 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1966 st070145 16.1 µM -0.250079422417047 0.4095744432149 no 2005 0.401262964505559 2796 3748532
SGTC_1545 lovastatin 49.4 µM -0.250743150125047 0.409317761300376 no 2006 0.401006348575767 2901 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2649 anisomycin 9.56 µM -0.252045358993745 0.408814274057819 no 2007 0.400503001926484 2898 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3267 9137951 49.47 µM -0.253546354419797 0.40823411447606 no 2008 0.399923022697561 2806 16643986
SGTC_2310 7668677 200 µM -0.254850773332221 0.40773009823779 no 2009 0.399419179104693 3072 2197143
SGTC_2732 terfenadine 20 µM -0.254929716279546 0.407699600253834 no 2010 0.399388692044004 2848 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_475 α-linolenic acid 10 µM -0.255133181212416 0.407620998341093 no 2011 0.399310118534356 3089 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1306 1185-0270 9.02 µM -0.255137430338364 0.407619356872173 no 2012 0.399308477662439 2970 1548076
SGTC_1449 4112-4002 201 µM -0.25523409691242 0.407582014294711 no 2013 0.399271148709053 2890 2059539
SGTC_3336 9143619 71.43 µM -0.25562710818307 0.407430201553512 no 2014 0.39911939219513 2923 45595730
SGTC_632 0781-2353 4.65 µM -0.255813952360976 0.407358032093684 no 2015 0.399047249937732 2943 6811515 YHR007C ERG11
SGTC_3256 9138902 49.47 µM -0.256307577235466 0.407167382252548 no 2016 0.398856673423199 2855 17228773
SGTC_609 0986-0026 86.3 µM -0.256508979054688 0.407089602323064 no 2017 0.398778924019949 2881 2848610
SGTC_1016 4226-1401 38 µM -0.256963530599831 0.406914071266408 no 2018 0.398603463155345 2809 2901613
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.257077580719746 0.406870032245576 no 2019 0.398559442028096 2846 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1457 k015-0032 57.3 µM -0.257452806675708 0.406725151770328 no 2020 0.39841462122099 2832 4302660
SGTC_3051 9093778 49.47 µM -0.258458937863497 0.406336732202742 no 2021 0.398026367689107 2864 17217378
SGTC_1663 st014140 55.4 µM -0.258584527320346 0.406288254527176 no 2022 0.397977911356619 2891 4207120
SGTC_1947 st076332 61.6 µM -0.259206414890052 0.40604822638802 no 2023 0.397737990923528 2947 24208416
SGTC_2420 aureobasidin a 50 nM -0.262376557473028 0.404825206269908 no 2024 0.396515572094506 3141 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2886 9058944 51.95 µM -0.262419819956047 0.404808522288552 no 2025 0.396498896922975 2897 4949929
SGTC_262 fenpropimorph 62.5 µM -0.262766057173816 0.404675003704679 no 2026 0.396365449431647 2850 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3218 9131285 49.47 µM -0.26314921015204 0.404527262326708 no 2027 0.396217787940377 3035 17156417
SGTC_1772 st048439 82.2 µM -0.263494231214594 0.404394236022113 no 2028 0.396084834663618 2962 2927068 YDL195W SEC31
SGTC_2256 7954252 200 µM -0.264331041205328 0.404071641540146 no 2029 0.395762421599158 2940 2972920
SGTC_354 2783-3500 4.88 µM -0.264566787712142 0.403980771836613 no 2030 0.395671604103134 2893 6740761
SGTC_2227 7312221 64.1025 µM -0.267541476287173 0.402834609558962 no 2031 0.394526142071749 2882 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2671 danthron 100 µM -0.267962961349529 0.402672276542415 no 2032 0.394363914490463 2935 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2364 9055074 200 µM -0.269046716922527 0.40225495021139 no 2033 0.393946866346837 2969 6470630
SGTC_3273 9137859 49.47 µM -0.269826793395934 0.401954631787742 no 2034 0.393646754472837 2920 2377234
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.270296442183151 0.40177385154028 no 2035 0.393466101127872 2863 3256 An antibiotic and ribosome inhibitor.
SGTC_1190 1486-1332 13 µM -0.270606734355542 0.401654423398494 no 2036 0.393346757879944 2911 4150046
SGTC_2993 9054257 71.4286 µM -0.273242570165544 0.400640289820274 no 2037 0.392333379157526 2873 6470217 YGL055W OLE1
SGTC_3159 9100096 49.47 µM -0.274863433546138 0.4000169971608 no 2038 0.391710580628005 2792 25236875
SGTC_178 4092-0806 87.505 µM -0.275133228320896 0.399913273979478 no 2039 0.391606941908596 2970 2169044
SGTC_2517 totarol 10 µM -0.275730005264298 0.399683866894176 no 2040 0.391377723893934 2970 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_400 oxethazaine 37.5 µM -0.27640722900507 0.399423577191621 no 2041 0.391117652492203 2958 4621 A local anesthetic.
SGTC_2727 riluzole 51.77 µM -0.276580829029056 0.39935686153411 no 2042 0.391050993434829 2897 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.276615392966631 0.399343578731071 no 2043 0.391037721932144 2999 616764
SGTC_3287 9117173 37.0625 µM -0.276753714570508 0.399290423377983 no 2044 0.390984611905738 2951 2789709
SGTC_1140 3229-1848 2.98 µM -0.276860028953427 0.399249569289546 no 2045 0.390943792768336 3005 2849525
SGTC_2872 9044037 25.97 µM -0.277637272634575 0.398950926579346 no 2046 0.390645408557099 2869 6465195
SGTC_3071 9117417 49.47 µM -0.278077614979751 0.39878175873086 no 2047 0.390476389484968 2955 45595590 YGL055W OLE1
SGTC_1789 tunicamycin 25 nM -0.278602931979317 0.398579970747461 no 2048 0.390274781187921 3020 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3134 9127454 49.47 µM -0.279845689084689 0.398102703302961 no 2049 0.38979794836086 2980 24262820
SGTC_484 loperamide 105 µM -0.279871819975461 0.398092669650223 no 2050 0.389787923990398 2868 3955 An opioid-receptor agonist.
SGTC_1565 sinapyl alcohol 95.1 µM -0.281322943424005 0.397535578046684 no 2051 0.38923135715215 2991 5280507 A phenol propionate derived from cinnamic acid.
SGTC_50 0929-0078 56.389 µM -0.281627046420795 0.397418858233895 no 2052 0.38911474962512 2908 1377751
SGTC_774 k060-0086 136 µM -0.281782151940019 0.397359329679542 no 2053 0.389055278650039 3052 5911235
SGTC_2 0422-0095 29 µM -0.281856407632302 0.397330831642866 no 2054 0.389026808252864 2933 6790840
SGTC_1265 0819-1001 68.8 µM -0.282227861401948 0.397188282410232 no 2055 0.38888439800059 2887 3106768
SGTC_2849 9019321 12.99 µM -0.2836272975264 0.396651357776367 no 2056 0.388348007709917 3031 16489627
SGTC_3168 9103419 49.47 µM -0.283736795183489 0.39660935482803 no 2057 0.388306047286803 2966 16649256
SGTC_447 ml7 120 µM -0.284193308501072 0.396434250723712 no 2058 0.388131121596602 2970 4216 Selective myosin light chain kinase inhibitor.
SGTC_1610 st001799 48.1 µM -0.285520619529556 0.395925254864556 no 2059 0.387622654734242 2863 621897
SGTC_2987 9018338 71.43 µM -0.287477164059214 0.39517528490799 no 2060 0.386873492385419 2954 5055682
SGTC_2184 6075246 200 µM -0.287563226174679 0.395142305028013 no 2061 0.386840548790848 2968 2267320
SGTC_1398 3558-0053 112 µM -0.288161687628887 0.394912989282933 no 2062 0.386611487142293 2874 4532369
SGTC_842 0271-0008 11.1 µM -0.288320017619336 0.394852327200849 no 2063 0.386550892803257 3033 1221709
SGTC_482 fipronil 114 µM -0.288959663969605 0.394607280963306 no 2064 0.386306122454671 2938 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3039 9090270 49.47 µM -0.289173531222923 0.394525358476956 no 2065 0.386224293002723 3028 17173750
SGTC_656 4090-1979 187 µM -0.289487326471172 0.394405166719365 no 2066 0.386104238466018 3054 22330961
SGTC_2264 7948757 110.76 µM -0.289522929822806 0.394391530342661 no 2067 0.386090617712309 2859 2971411
SGTC_1673 st016611 27.3 µM -0.290079887685993 0.394178227756023 no 2068 0.385877560951221 3117 5226799
SGTC_1651 st011928 86.1 µM -0.293326758913937 0.392935381314221 no 2069 0.384636201036546 3032 720198
SGTC_3040 9091894 49.47 µM -0.293429161110087 0.3928962011911 no 2070 0.384597069280524 2916 25236966
SGTC_1870 st057514 26.5 µM -0.294493721621402 0.392488953842831 no 2071 0.384190330124093 2888 5393161
SGTC_3182 9108849 49.47 µM -0.295835587415214 0.391975791154942 no 2072 0.383677821970883 3027 17133045
SGTC_3098 9119039 49.47 µM -0.296318656957924 0.391791099345771 no 2073 0.383493369604966 2906 17161528
SGTC_1262 0737-0114 49.6 µM -0.296625138324849 0.391673935071924 no 2074 0.383376358291005 3088 765919
SGTC_1861 st057647 17.4 µM -0.297060696715513 0.391507443053596 no 2075 0.383210085049989 3104 688668
SGTC_2016 5121758 140 µM -0.297568671163175 0.391313295131607 no 2076 0.383016194351045 2862 2795203
SGTC_3035 9091303 49.47 µM -0.300510638190019 0.39018940874824 no 2077 0.381893841552075 2937 25237002
SGTC_310 1273-0058 1.06 µM -0.300781087075661 0.390086138111209 no 2078 0.381790715647672 3049 2734232
SGTC_1394 3474-0001 65.7 µM -0.302303216756882 0.38950505928941 no 2079 0.381210463188297 2979 5017666 YIL048W NEO1
SGTC_3157 9099274 49.47 µM -0.303496525783726 0.389049681624467 no 2080 0.380755747360815 3065 17217662
SGTC_1965 Pectolinarigenin 58.4 µM -0.306679814743402 0.387835656302002 no 2081 0.379543547695529 2955 5320438 An anti-inflammatory.
SGTC_1683 st010134 710 nM -0.307164048867954 0.387651077454134 no 2082 0.37935925422418 2930 3818134
SGTC_1737 st035557 69.7 µM -0.307989617571588 0.387336448318118 no 2083 0.379045116288987 2908 5716916
SGTC_1381 2324-0066 62.1 µM -0.308153504351841 0.387273998888154 no 2084 0.378982765068447 3068 10885928
SGTC_1020 4335-0961 93.3 µM -0.30838681481929 0.387185100437336 no 2085 0.378894006828899 2902 669075
SGTC_1734 st037168 69.4 µM -0.308620481679169 0.387096072120138 no 2086 0.378805119407629 3029 708907
SGTC_1513 0337-0559 19 µM -0.310701630365614 0.386303405913177 no 2087 0.37801372885433 2971 775073
SGTC_1751 st044839 27.194 µM -0.311006797840688 0.386187213768438 no 2088 0.377897726902558 2954 5291326
SGTC_988 1497-1057 103 µM -0.311110989274214 0.386147545343705 no 2089 0.377858123598014 3002 3533044
SGTC_1995 st072814 61.1 µM -0.313121223596937 0.385382429622578 no 2090 0.377094282595512 2962 5769371
SGTC_1491 4138-0063 26.5 µM -0.313820337550056 0.385116444055064 no 2091 0.376828748504552 3048 23883227
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.31437584294997 0.384905134460562 no 2092 0.376617800647511 3017 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2840 9008771 71.43 µM -0.314631875406393 0.384807753365076 no 2093 0.376520587171401 3072 2992978
SGTC_881 0833-0569 170 µM -0.315255217165717 0.38457069778706 no 2094 0.376283942042577 2974 5418700
SGTC_816 0325-0417 81.3 µM -0.315699418662263 0.384401795207783 no 2095 0.376115333995899 3008 68101
SGTC_2942 9052777 62.25 µM -0.316016769108419 0.384281139738704 no 2096 0.3759948899896 2988 6469503
SGTC_716 1683-5115 658 µM -0.316532616893778 0.384085040242249 no 2097 0.375799136071903 2946 723597
SGTC_2769 toremifene 3.73 µM -0.317171696030765 0.383842135511406 no 2098 0.375556662651274 3171 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2441 5730946 39.09 µM -0.319393725464319 0.382997929992436 no 2099 0.374713984111462 3096 1774275
SGTC_497 capsazepine 133 µM -0.320545287245127 0.382560640629246 no 2100 0.374277502806487 2977 2733484 A calcium channel blocker.
SGTC_2017 5132927 60.65 µM -0.320873682758346 0.3824359644669 no 2101 0.374153059170448 2981 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2816 7982706 58.44 µM -0.323528110410962 0.38142865286121 no 2102 0.373147661100225 3073 2981853
SGTC_972 1319-0219 195 µM -0.323553590866547 0.381418987326279 no 2103 0.37313801422708 3051 23903702
SGTC_1296 1068-0102 11.9 µM -0.324680305765971 0.380991663091229 no 2104 0.372711520768062 3068 767053
SGTC_798 1287-0182 476 µM -0.324683955289549 0.380990279187855 no 2105 0.372710139573353 3170 1649755
SGTC_2839 9003951 25.97 µM -0.325317251587816 0.380750155597566 no 2106 0.37247048774518 3084 2990634
SGTC_2806 7952793 58.44 µM -0.325618072506605 0.380636111012565 no 2107 0.372356668457209 3120 2972490
SGTC_172 1112-0046 2.638 µM -0.328042818511933 0.379717242120987 no 2108 0.371439643914759 3001 2802135 YIL048W NEO1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.328068309372271 0.379707585836218 no 2109 0.371430007287191 3107 521171
SGTC_982 1491-0518 27.5 µM -0.328168418780655 0.379669663755909 no 2110 0.371392162459878 2976 3091256
SGTC_2372 9071633 200 µM -0.328617383814501 0.379499607185574 no 2111 0.371222453406593 3119 21321366
SGTC_1490 4089-0339 670 nM -0.330025323956709 0.378966466458325 no 2112 0.370690413691347 3086 742542
SGTC_1059 3448-6867 171 µM -0.33063221110629 0.378736729144016 no 2113 0.370461156205431 2987 3934407
SGTC_3184 9108758 49.47 µM -0.331255716046926 0.378500745776926 no 2114 0.370225669092927 2930 902885
SGTC_1348 1493-0373 93.8 µM -0.332037821475538 0.378204799557606 no 2115 0.369930350070152 3041 3010129
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.332551695589813 0.378010390098962 no 2116 0.369736355557118 2967 803109
SGTC_1120 ficusin 1.78878 µM -0.332584478045133 0.377997988849527 no 2117 0.369723980855777 3128 6199 A DNA cross-linker.
SGTC_2047 4141938 200 µM -0.334181222712279 0.377394109969536 no 2118 0.369121406203114 3021 3807862
SGTC_155 k072-0202 43.6 µM -0.334905971301543 0.377120113349676 no 2119 0.368848008763437 3031 5857737
SGTC_948 3448-0295 75.3 µM -0.335457551455614 0.376911625796109 no 2120 0.368639980237257 2976 678569
SGTC_862 0452-0056 10.2 µM -0.33698040069074 0.376336202164021 no 2121 0.368065837442284 3072 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1312 1218-2183 165 µM -0.337799914534363 0.376026654383906 no 2122 0.367756987148432 3022 6744073
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.337954905406271 0.375968120001977 no 2123 0.367698585324673 3012 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2337 9009472 200 µM -0.338573768240367 0.37573442660819 no 2124 0.36746542326957 3207 5742383
SGTC_1875 nocodazole 6 µM -0.339259900048589 0.375475384556123 no 2125 0.367206974138712 3120 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1616 st002734 56.1 µM -0.33935321005352 0.375440160650712 no 2126 0.367171831178019 2997 4026101
SGTC_1206 3978-0017 132 µM -0.340006892765079 0.375193428913266 no 2127 0.366925668584813 3248 3873677
SGTC_3316 9136639 10.545 µM -0.340781692964035 0.374901047656063 no 2128 0.366633966654098 3104 4903665
SGTC_2610 ononetin 44.17 µM -0.341526047439328 0.374620223200164 no 2129 0.366353799660394 3052 259632
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.34231293830057 0.374323423228985 no 2130 0.366057699867381 3083 279621
SGTC_218 alverine citrate 93.75 µM -0.343764002580945 0.373776305303646 no 2131 0.365511886965797 3143 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2706 st078239 82.5 µM -0.344725259859522 0.373414007056038 no 2132 0.365150463125469 3017 15434492
SGTC_1559 coumarin 343 70.1 µM -0.34504224002635 0.373294561617134 no 2133 0.36503130775576 3175 108770 A hepatotoxic, DNA x-linker.
SGTC_415 dibenzyl ketone 100 µM -0.346190213543887 0.372862080677627 no 2134 0.364599884500669 3082 7593
SGTC_33 0986-0033 35.816 µM -0.346393326235262 0.372785577834373 no 2135 0.364523569965128 3045 2848082
SGTC_689 0833-0039 98 µM -0.346585927730466 0.372713038690891 no 2136 0.364451209709212 3060 5374726
SGTC_1991 st073000 8.92 µM -0.346785965199733 0.372637703728977 no 2137 0.364376060876152 3207 4301969 YIL048W NEO1
SGTC_701 4424-0219 185 µM -0.347073490482264 0.37252942901892 no 2138 0.364268054297216 3195 2911779
SGTC_737 1950-0117 57.9 µM -0.347095429946857 0.372521167587976 no 2139 0.364259813354812 3154 5393513
SGTC_3243 9134147 49.47 µM -0.347648670917962 0.37231286093133 no 2140 0.3640520247076 3092 24282180
SGTC_2919 7978188 46.38 µM -0.348239115121617 0.372090587695134 no 2141 0.363830307192112 3201 2980291
SGTC_845 0330-0138 4.51 µM -0.348697227524693 0.371918160235287 no 2142 0.363658312949776 3072 9039800
SGTC_2153 5569715 200 µM -0.35046999110802 0.371251157725567 no 2143 0.362993003708961 3056 2054701
SGTC_2045 5106652 78.05 µM -0.350813328616188 0.371122021562967 no 2144 0.362864198580791 3125 673349
SGTC_1720 st037298 9.481 µM -0.352465844874446 0.370500680089616 no 2145 0.362244464441885 3124 597396
SGTC_1029 k015-0030 64.7 µM -0.352500145901511 0.370487786571408 no 2146 0.362231604533007 3136 2208316
SGTC_2473 5854593 8.94 µM -0.352509250955867 0.37048436406905 no 2147 0.362228190953777 2965 2872951
SGTC_964 1287-0107 19.4 µM -0.3529308007582 0.37032591878117 no 2148 0.362070159564839 3185 51516812 YPR165W RHO1
SGTC_2021 4019055 173 µM -0.353623447098446 0.370065625912692 no 2149 0.361810550053254 3188 44827708 YER133W GLC7
SGTC_1107 amlodipine 47 µM -0.353845847509136 0.369982061617078 no 2150 0.361727206040533 3095 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_495 decylubiquinone 155 µM -0.354360333218362 0.369788773291852 no 2151 0.361534428914025 3085 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2271 7849410 118.62 µM -0.35439628759916 0.369775266736566 no 2152 0.361520958167528 3175 972430
SGTC_261 5-fluorouridine 15.376 µM -0.354510771076325 0.369732261158432 no 2153 0.361478066682483 3242 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3313 9133968 57.047 µM -0.355169783393191 0.369484735687763 no 2154 0.361231200143062 3010 1494643
SGTC_2739 tacrine 100.86 µM -0.355527518586598 0.369350392749943 no 2155 0.36109721644186 3123 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1026 k007-1105 30.6 µM -0.355688141016683 0.369290078211487 no 2156 0.361037063553677 3017 7066794
SGTC_2040 5100729 123 µM -0.355738802086285 0.369271055389843 no 2157 0.361018091762758 3026 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1101 ebselen 5.29 µM -0.355878597977907 0.369218564824378 no 2158 0.360965742126323 3179 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_604 1000-0114 314 µM -0.35745596863501 0.368626462832348 no 2159 0.360375241793333 3174 1572745
SGTC_1764 st044502 93.5 µM -0.360229362878551 0.367586162838097 no 2160 0.359337809110573 3167 8407
SGTC_1725 st036284 20.55 µM -0.362170446433794 0.366858639558793 no 2161 0.358612331454058 3248 707914
SGTC_1403 3909-7815 62.9 µM -0.362313412764747 0.366805074264254 no 2162 0.35855891808813 3010 6615483
SGTC_308 4092-1169 104 µM -0.362769945423334 0.366634042224436 no 2163 0.358388372359571 3046 2268590 YDL196W YDL196W
SGTC_1518 st038567 90.8 µM -0.36296787822979 0.366559898358899 no 2164 0.358314439886276 3103 77966
SGTC_426 0988-0037 14.6 µM -0.363032725470976 0.366535608243013 no 2165 0.35829021909942 3234 5383008
SGTC_2244 6635614 200 µM -0.363055309184137 0.366527149087903 no 2166 0.358281784097215 2938 836499
SGTC_1128 3448-9350 235 µM -0.363782978122611 0.366254621705333 no 2167 0.358010037256405 3106 619386
SGTC_1186 1319-0216 26 µM -0.364530347407422 0.365974786333515 no 2168 0.357731008225663 3187 4565136
SGTC_80 0159-0065 512.242 µM -0.365716255623008 0.365530896410848 no 2169 0.357288407489882 3126 1548079
SGTC_1797 st048695 56.8 µM -0.365911280289957 0.365457915163446 no 2170 0.357215639391018 3160 592262 YIL048W NEO1
SGTC_3211 9128781 49.47 µM -0.366019737362889 0.365417330956373 no 2171 0.3571751738593 3135 17194361
SGTC_1416 3966-0321 25.3 µM -0.366421032486114 0.365267181016255 no 2172 0.357025463887578 3091 582530 YLR208W SEC13
SGTC_2680 butyl paraben 22.24 µM -0.368751198963663 0.364395726795942 no 2173 0.356156591305593 3111 7184 An antifungal and steroid mimetic.
SGTC_3248 9135562 49.47 µM -0.369085692849664 0.364270687497015 no 2174 0.356031926366105 3105 17650701
SGTC_2797 7859098 81.82 µM -0.369929366186341 0.363955372760261 no 2175 0.355717560051861 3051 972681
SGTC_2969 9091408 28.7 µM -0.370298909028431 0.363817288692889 no 2176 0.355579893302601 3012 4286311
SGTC_653 0203-0016 55.2 µM -0.372009909673278 0.363178183748545 no 2177 0.354942735587977 3111 295302
SGTC_1813 st051246 8.6015 µM -0.372026762083815 0.363171890808895 no 2178 0.354936461950347 3150 5291959
SGTC_509 pifithrin 175 µM -0.372623059206796 0.362949248419947 no 2179 0.354714504076632 3160 4817 A p53 inhibitor.
SGTC_2348 9022543 33.42 µM -0.37269474719125 0.362922485041915 no 2180 0.35468782319433 3177 3162678 YDL140C RPO21
SGTC_1068 loratadine 26.9 µM -0.37302990645071 0.362797368438812 no 2181 0.354563092854506 3100 3957 A H1 histamine antagonist.
SGTC_1924 st058459 75.1 µM -0.37492978053375 0.36208841325784 no 2182 0.353856345137259 3118 688683
SGTC_68 0986-0284 82.829 µM -0.374991883531854 0.362065246931464 no 2183 0.353833251481894 3215 423278 YIL048W NEO1
SGTC_3345 9148410 3.559 µM -0.375097289702127 0.362025928348086 no 2184 0.353794056315955 3186 4903596
SGTC_1815 st051655 58.2 µM -0.375565189391306 0.361851410104933 no 2185 0.353620087054926 3168 5984156
SGTC_1152 3909-8331 15.9 µM -0.375631263830105 0.361826767830889 no 2186 0.353595522454002 3091 16001939
SGTC_1628 st004252 77.7 µM -0.37637587991331 0.361549105008877 no 2187 0.353318737500114 3189 692968
SGTC_1916 st067606 49.2 µM -0.376619305002237 0.361458349072283 no 2188 0.353228269563326 3118 19590279
SGTC_3053 9095903 49.47 µM -0.377043219020532 0.361300320234595 no 2189 0.353070743455582 3147 17174018
SGTC_104 0074-0074 590.992 µM -0.381785918352673 0.35953393149206 no 2190 0.351310082273747 3021 3943124
SGTC_3246 9135460 32.98 µM -0.382067411366704 0.359429185033446 no 2191 0.351205681706833 3156 41446951
SGTC_1980 st071811 45.7 µM -0.383013780561899 0.359077108765433 no 2192 0.350854773193458 3223 4974850
SGTC_2074 5212007 75.395 µM -0.383039961268624 0.359067370497194 no 2193 0.350845067337311 3188 758611
SGTC_3167 9103034 49.47 µM -0.383494935180474 0.358898151421447 no 2194 0.350676412444668 3128 5127859
SGTC_1113 artemisinin 1.17947 µM -0.385180325972181 0.35827154317809 no 2195 0.350051909279085 3181 2240 An anti-malaria and mitochondrial poison.
SGTC_1975 st070967 30.8 µM -0.385683852363585 0.358084411993952 no 2196 0.349865411629395 3246 261391
SGTC_2354 9060492 162 µM -0.386424115503399 0.357809361574484 no 2197 0.349591296465179 3232 6471895
SGTC_3070 9117005 49.47 µM -0.387567488021794 0.357384677874266 no 2198 0.34916806633726 3170 8779016
SGTC_1550 gossypolone 36.6 µM -0.388455927561059 0.357054805989765 no 2199 0.348839331489046 3082 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3172 9105863 49.47 µM -0.388864558449182 0.356903119822391 no 2200 0.348688170511838 3119 2348785
SGTC_2226 7298446 200 µM -0.390533181246009 0.356283952319434 no 2201 0.348071162100505 3185 3283010
SGTC_57 miconazole 162.5 nM -0.390835015101942 0.356171992741394 no 2202 0.347959595564169 3146 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2857 9024691 58.44 µM -0.391133417841488 0.356061318059158 no 2203 0.347849310204673 3169 16478292
SGTC_766 1391-0721 126 µM -0.391868389028541 0.355788776108074 no 2204 0.347577730337495 3232 1020919 YIL115C NUP159
SGTC_2385 9074692 200 µM -0.391936018949624 0.35576370128719 no 2205 0.347552744271667 3114 17046906
SGTC_188 3229-0966 278.469 µM -0.396439521762515 0.354095368405711 no 2206 0.345890407592322 3221 5722370
SGTC_409 arachidonic acid 100 µM -0.397396166385318 0.353741336313514 no 2207 0.345537671019876 3117 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2885 9057732 51.95 µM -0.397429890939258 0.353728857940325 no 2208 0.345525238456805 3237 6471414
SGTC_668 1682-0499 62.6 µM -0.397734041366148 0.353616326784236 no 2209 0.345413120875021 3155 682214
SGTC_3038 9091290 49.47 µM -0.398370256109139 0.353380978119121 no 2210 0.345178639807617 3266 25236843
SGTC_2647 atorvastatin 60.16 µM -0.398664601723606 0.353272112699119 no 2211 0.345070176923834 3169 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2555 cholic acid 100 µM -0.399222779074128 0.353065700568069 no 2212 0.344864530117244 3259 6708657 Influences liver metabolism.
SGTC_2298 7976326 193.81 µM -0.400431633543381 0.352618818452477 no 2213 0.34441931437054 3106 2235818
SGTC_1414 3917-0015 5.4 µM -0.400788160835481 0.352487058364685 no 2214 0.344288048067146 3211 6618702
SGTC_3145 9085516 49.47 µM -0.401753011266506 0.352130571997251 no 2215 0.343932903304589 3195 25236195
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.401988744570496 0.352043494595789 no 2216 0.343846154862349 3235 5282362
SGTC_830 4076-0286 57.8 µM -0.402215551563522 0.351959721802558 no 2217 0.343762699008045 3113 6866659
SGTC_1746 st038117 42 µM -0.40279495722615 0.351745746788438 no 2218 0.343549535593986 3181 2898218
SGTC_1035 k081-0041 55.2 µM -0.402858926371305 0.351722125804557 no 2219 0.343526004385653 3258 731709
SGTC_2096 5468907 200 µM -0.403144812452166 0.351616567680675 no 2220 0.343420847895466 3200 759785
SGTC_2431 5490079 200 µM -0.404137846425284 0.351249997263947 no 2221 0.343055677841248 3166 5722345
SGTC_1989 st071868 50.2 µM -0.405680736077358 0.350680726639056 no 2222 0.342488599222555 3226 16414057
SGTC_1060 3448-7350 82 µM -0.405742936743904 0.350657783855815 no 2223 0.342465745223042 3225 570178
SGTC_2107 5363541 170.161 µM -0.406297900450925 0.350453109008927 no 2224 0.342261863938736 3224 244052
SGTC_1955 wogonin 32.4 µM -0.409042683395292 0.349441451470339 no 2225 0.341254168811923 3320 5281703 A flavanone.
SGTC_709 3807-1509 243 µM -0.409959070232319 0.349103932036484 no 2226 0.340917986186515 3183 1886677 YPL242C IQG1
SGTC_2435 5706476 10.6 µM -0.410454383483145 0.348921550173623 no 2227 0.340736329771865 3273 5725375
SGTC_715 0868-0130 184 µM -0.410697754713297 0.348831949973385 no 2228 0.340647086763121 3276 2876258
SGTC_677 0929-0063 136 µM -0.410916073982918 0.348751580142116 no 2229 0.340567037772049 3182 1539583
SGTC_115 0527-0192 112.043 µM -0.412102285143603 0.348315019148948 no 2230 0.340132226915589 3226 4233931
SGTC_728 3030-5151 22.5 µM -0.412157683921099 0.348294635656437 no 2231 0.340111925442868 3122 3125388
SGTC_298 1391-0729 10 µM -0.41296856698058 0.347996328544942 no 2232 0.339814821774826 3118 3237558
SGTC_2674 ligustilide 100 µM -0.413754410333851 0.347707322751695 no 2233 0.339526987447642 3205 5319022 A signalling regulator.
SGTC_2612 dictamnine 15.46 µM -0.414459095724387 0.34744823926245 no 2234 0.339268958779171 3186 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1340 1486-1359 257 µM -0.415499622744959 0.347065811090856 no 2235 0.338888095634794 3152 4309068
SGTC_2630 antimycin a 100 µM -0.416542863759219 0.346682541739209 no 2236 0.338506404360989 3089 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_536 3852-0578 10.6 µM -0.41782103707042 0.346213176031528 no 2237 0.3380389843392 3273 2869208
SGTC_938 3126-1755 342 µM -0.419656421976679 0.345539606383617 no 2238 0.337368232127995 3305 1777771
SGTC_2357 9067248 200 µM -0.419743204644186 0.345507770015385 no 2239 0.337336529663616 3218 9150235
SGTC_1515 3460-0031 42.1 µM -0.42047171716842 0.345240557076191 no 2240 0.337070443248061 3192 2876596
SGTC_202 3594-0513 34.79 µM -0.420530127880646 0.345219135802644 no 2241 0.33704911248608 3171 708429
SGTC_376 3970-0862 59.1 µM -0.420553311113094 0.345210633829021 no 2242 0.33704064644431 3246 3135186
SGTC_516 3992-2719 87.3 µM -0.421630416074345 0.344815713933186 no 2243 0.336647400834623 3048 5350887 YDR037W KRS1
SGTC_890 0929-0006 47.2 µM -0.422232334316051 0.344595094556257 no 2244 0.336427721253191 3145 1378169
SGTC_1440 4100-1550 40 µM -0.423819073623797 0.344013764973684 no 2245 0.335848883368045 3185 742806
SGTC_574 1315-0397 40 µM -0.424386643800035 0.34380591516086 no 2246 0.335641929845625 3176 6794277
SGTC_363 0455-0021 3.06 µM -0.424578315851116 0.343735733618094 no 2247 0.335572051583046 3126 4597466
SGTC_1051 3253-3903 78 µM -0.424873097278688 0.343627808645445 no 2248 0.335464593627577 3096 5509239
SGTC_195 4234-0266 16.654 µM -0.426211851985417 0.343137826093387 no 2249 0.334976741011352 3164 2303354
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.426429587572357 0.343058160042773 no 2250 0.334897422763817 3310 551469
SGTC_736 0958-0254 92.6 µM -0.426993569150772 0.342851840434153 no 2251 0.334692005846071 3273 6812352
SGTC_3088 9117578 49.47 µM -0.42795953639723 0.342498572554705 no 2252 0.334340290117261 3262 678341
SGTC_2384 9036245 200 µM -0.431668095074169 0.341143582002266 no 2253 0.3329913295498 3183 6462766
SGTC_869 0564-0080 44.1 µM -0.431863225038665 0.341072344166126 no 2254 0.332920412101962 3192 6843321
SGTC_2046 4110841 106 µM -0.431975964947141 0.341031187784291 no 2255 0.332879440972102 3308 44119630 YMR134W ERG29
SGTC_2537 larixol 68.93 µM -0.432384401336256 0.34088210146522 no 2256 0.332731026656891 3262 6708759
SGTC_2570 licareol 100 µM -0.432669834054336 0.340777928352766 no 2257 0.332627323977986 3202 443158
SGTC_1835 st008666 49.2 µM -0.433130915464823 0.34060967516656 no 2258 0.332459832124331 3132 690455
SGTC_719 2810-4230 27.3 µM -0.433540590350369 0.340460207335802 no 2259 0.332311042200072 3213 721079
SGTC_1078 idebenone 36.1 µM -0.433663641854812 0.340415317502567 no 2260 0.332266356252877 3230 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_454 lyso-paf C-16 6.67 µM -0.434274295254182 0.340192581406227 no 2261 0.332044633785739 3212 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_181 1447-1644 8.07 µM -0.435275942893419 0.339827350741501 no 2262 0.331681072350433 3244 534600
SGTC_2621 lithochol-11-enic acid 100 µM -0.435499864759064 0.339745722681957 no 2263 0.331599818571618 3300 6708711
SGTC_1596 piperlongumine 63 µM -0.4361487545108 0.339509220073701 no 2264 0.331364402876615 3304 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3296 9122258 64.045 µM -0.438051817500497 0.33881597024429 no 2265 0.330674360520302 3255 4730474
SGTC_2022 5136654 200 µM -0.43863329951075 0.338604256069844 no 2266 0.330463632269862 3278 1713771
SGTC_3320 9137005 35.139 µM -0.438675115115876 0.338589033218938 no 2267 0.330448480424839 3214 4908713
SGTC_1489 4065-0444 182 µM -0.440122392568929 0.338062318688646 no 2268 0.329924232235572 3280 2877968
SGTC_2000 st075254 36.4 µM -0.441082682415771 0.337713010648526 no 2269 0.3295765700419 3245 17234175
SGTC_2423 st077119 87.2 µM -0.441745996638363 0.337471809881524 no 2270 0.329336510505494 3227 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_488 nitrendipine 139 µM -0.44253903043621 0.33718352684931 no 2271 0.32904959657256 3241 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_365 0121-0052 13.6 µM -0.443603739528636 0.336796634943791 no 2272 0.328664550810038 3290 3101739
SGTC_445 e6 berbamine 66 µM -0.445402796227534 0.336143289716684 no 2273 0.328014345918248 3266 6610268 A calcium/calmodulin antagonist.
SGTC_650 1328-0195 38 µM -0.445717221544694 0.336029153780774 no 2274 0.327900761516834 3282 2780821
SGTC_2266 7929956 200 µM -0.448787183538344 0.334915557769454 no 2275 0.326792592556564 3244 2967153
SGTC_208 k072-0098 12.366 µM -0.451646431165855 0.333879699761488 no 2276 0.325761857565507 3214 5948901
SGTC_905 2-aminofluorene 215 µM -0.452490485582682 0.333574154234492 no 2277 0.325457836964652 3231 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2742 clothiapine 36.27 µM -0.453482774580779 0.333215089308336 no 2278 0.325100572114374 3255 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_607 4491-0986 66.8 µM -0.453548010073144 0.33319148885659 no 2279 0.325077090281726 3318 698981 YDR232W HEM1
SGTC_555 4296-0685 37 µM -0.453757606014434 0.333115667136254 no 2280 0.325001649906028 3260 2908540 YHR072W ERG7
SGTC_1346 1488-2224 62.4 µM -0.455749634964917 0.332395387825223 no 2281 0.324285012588458 3319 3722427
SGTC_1904 st060225 78 µM -0.455867008745813 0.332352966996485 no 2282 0.3242428073476 3288 66595
SGTC_1251 0490-5699 265 µM -0.456949906262445 0.331961691260551 no 2283 0.323853525859609 3381 3883818
SGTC_1203 3992-3522 103 µM -0.45700134706105 0.331943109073108 no 2284 0.323835038639105 3490 5322312
SGTC_2077 5212015 200 µM -0.457422508817536 0.331790986496751 no 2285 0.323683694385524 3195 780900
SGTC_1456 k015-0012 13 µM -0.458072710950839 0.331556189565661 no 2286 0.323450101848085 3382 2989616
SGTC_752 1896-0090 130 µM -0.458429982257361 0.331427202148092 no 2287 0.323321777661506 3255 772567
SGTC_1730 st033808 45.1 µM -0.458740294489265 0.331315184818832 no 2288 0.323210337220218 3169 1045166
SGTC_1866 st057638 64 µM -0.459451366239654 0.331058557182633 no 2289 0.322955034418372 3220 688802
SGTC_98 0074-0023 107.663 µM -0.459481961336104 0.331047517112703 no 2290 0.322944051442691 3272 3563821
SGTC_2734 clemastine 41.6 µM -0.46006092319885 0.330838629653387 no 2291 0.322736245812169 3235 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_82 0054-0107 293.755 µM -0.460282180511051 0.330758814676276 no 2292 0.322656844978369 3258 3104697
SGTC_2281 7943571 200 µM -0.461129818285239 0.330453114357468 no 2293 0.32235273487264 3403 1244024
SGTC_2409 alverine citrate 63.97 µM -0.461356387509508 0.33037142137946 no 2294 0.322271467924718 3404 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2809 7964133 12.99 µM -0.461615087386421 0.330278153090665 no 2295 0.32217868658536 3225 1253665
SGTC_2755 lomerizine 42.69 µM -0.461799566880033 0.330211649693403 no 2296 0.322112530760019 3220 3949 A calcium channel blocker.
SGTC_2383 9036125 200 µM -0.462343823831379 0.330015480630205 no 2297 0.321917388700509 3192 79580
SGTC_1908 st060353 56.5 µM -0.462373869904907 0.330004652344877 no 2298 0.321906617180628 3385 4227716
SGTC_1690 st023502 41.2 µM -0.463426120818317 0.329625522196922 no 2299 0.32152947958221 3303 24207482
SGTC_3001 9076041 71.4286 µM -0.465190030407285 0.328990371384553 no 2300 0.32089768876597 3226 16004211
SGTC_723 4182-0001 115 µM -0.46672069737583 0.328439606644682 no 2301 0.320349859852586 3227 744821 YLR208W SEC13
SGTC_3308 9128332 17.569 µM -0.467489297716123 0.328163189232005 no 2302 0.320074923664048 3348 17332805 YDL196W YDL196W
SGTC_502 l-744,832 89.3 µM -0.467539217805467 0.328145239353558 no 2303 0.320057070152934 3318 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1088 bifonazole 369 nM -0.469023131115161 0.327611846697758 no 2304 0.319526551153635 3288 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_888 0916-0002 6.97 µM -0.469728456616163 0.327358440653855 no 2305 0.319274517145201 3367 2802138 YIL048W NEO1
SGTC_1237 0330-0133 46.1 µM -0.471243535693804 0.326814379168685 no 2306 0.318733416244578 3222 X1237 YHR072W ERG7
SGTC_1557 sumaresinolic acid 42.3 µM -0.473163276101988 0.326125533335668 no 2307 0.318048347924235 3236 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_185 k048-0037 25.491 µM -0.474979694474009 0.325474307500037 no 2308 0.317400723207766 3353 6827589
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.477492093497625 0.324574435115221 no 2309 0.316505874813511 3276 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_206 4546-0025 72.014 µM -0.478056088694989 0.324372567949739 no 2310 0.316305142318383 3338 6620745 YIL048W NEO1
SGTC_1384 3089-0840 101 µM -0.478524545978426 0.324204935281833 no 2311 0.316138454024249 3334 1069836
SGTC_3176 9106582 49.47 µM -0.478700764508544 0.324141886495932 no 2312 0.316075760929991 3266 17018027
SGTC_344 k064-0035 6.43 µM -0.478813412517416 0.324101585089593 no 2313 0.316035687028657 3212 5088750
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.47906522067492 0.324011504640921 no 2314 0.315946115496493 3295 16486 A toxic proline analog.
SGTC_2028 5153890 36.43 µM -0.479214811493913 0.323957995732538 no 2315 0.315892909155446 3270 2830968 YPR165W RHO1
SGTC_1411 3909-8223 150 µM -0.479472982592615 0.323865656016733 no 2316 0.315801092040532 3342 X1411
SGTC_1561 5-methoxyflavone 52.9 µM -0.480864560998114 0.32336811879521 no 2317 0.315306380767585 3312 94525
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.482022868438874 0.322954224675105 no 2318 0.314894850523572 3415 94937 An inhibitor of serotonin biosynthesis.
SGTC_2312 7706453 155.7 µM -0.482931242141795 0.322629791832298 no 2319 0.314572278884895 3234 976098
SGTC_1221 2958-7315 257 µM -0.483471754027772 0.322436807784773 no 2320 0.314380405396328 3339 4562705
SGTC_324 1315-0088 19.6 µM -0.484644559531834 0.322018234557405 no 2321 0.31396424976771 3321 6787421
SGTC_2875 9039966 71.43 µM -0.484871776072917 0.321937167259526 no 2322 0.313883652099976 3287 6463691
SGTC_1393 3470-5649 58.2 µM -0.485102824182873 0.321854741606891 no 2323 0.313801704412876 3286 4108395
SGTC_1289 0976-0073 69.1 µM -0.485620525873964 0.321670085060306 no 2324 0.313618120349999 3348 3391136
SGTC_1081 sertraline 6 µM -0.485947462243512 0.321553494373554 no 2325 0.313502208037053 3368 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1953 st076800 12.1 µM -0.486136605081908 0.321486051066426 no 2326 0.3134351575734 3263 297591
SGTC_405 ebelactone b 50 µM -0.486388135002435 0.321396371300397 no 2327 0.31334600066178 3287 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2964 9083345 53.42 µM -0.488390681246026 0.320682760866548 no 2328 0.312636570617283 3270 17741579
SGTC_75 0159-0059 199.013 µM -0.489797831338186 0.320181716706829 no 2329 0.312138482733461 3502 5377270
SGTC_592 k241-0073 46.5 µM -0.489849281904854 0.32016340290021 no 2330 0.312120277312867 3364 4230158
SGTC_642 0335-0876 158 µM -0.490943842487509 0.319773898402818 no 2331 0.311733083528654 3303 6812350
SGTC_2459 5811157 9.22 µM -0.491049807052614 0.319736200957682 no 2332 0.311695610281385 3341 2870684 YBR192W RIM2
SGTC_419 nsc-638432 893 µM -0.491438735834415 0.319597853482939 no 2333 0.311558086447207 3293 368090
SGTC_356 1634-0012 32.5 µM -0.491502140289257 0.319575301999719 no 2334 0.311535669348663 3364 735457
SGTC_2255 7941087 197.44 µM -0.491642226455317 0.319525478988903 no 2335 0.31148614335949 3382 935561
SGTC_714 4296-0578 26.1 µM -0.492363564393528 0.319268979707661 no 2336 0.311231175942387 3270 1589775
SGTC_703 3875-0075 71.8 µM -0.493408637028125 0.318897517605036 no 2337 0.310861940407262 3301 2850814
SGTC_1605 st000082 49.1 µM -0.49470871449569 0.318435670046676 no 2338 0.310402874605786 3362 1114022
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.494947826574507 0.31835075707658 no 2339 0.310318474694763 3446 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2724 maprotiline 69.64 µM -0.495027571992465 0.318322440176041 no 2340 0.310290329001785 3391 4011 A tricyclic antidepressant.
SGTC_1873 rapamycin 2 nM -0.495347926412151 0.318208695822118 no 2341 0.310177272924531 3301 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_209 4077-0173 175.592 µM -0.495932946465009 0.318001024091517 no 2342 0.309970860163178 3304 15993494
SGTC_2731 amoxapine 43.43 µM -0.496371170180501 0.31784549993144 no 2343 0.309816280810474 3353 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_633 0437-0093 97.7 µM -0.497842767722891 0.317323470002647 no 2344 0.309297434567598 3306 2831118
SGTC_1305 1181-0477 144 µM -0.498898801625653 0.316949079579788 no 2345 0.308925339164623 3397 6252086
SGTC_3080 9117754 49.47 µM -0.499614494608598 0.316695455001757 no 2346 0.308673274885554 3459 9550191
SGTC_2540 epiandrosterone 100 µM -0.500307960503724 0.316449789343072 no 2347 0.308429124859338 3400 441302 A steroid.
SGTC_2841 9004761 38.96 µM -0.500500679196552 0.316381531627776 no 2348 0.308361289010475 3273 2991039
SGTC_1907 st060210 83.7 µM -0.500550570056525 0.316363862144567 no 2349 0.308343728786633 3405 688793
SGTC_940 3232-1287 54.8 µM -0.501266407841275 0.316110385256385 no 2350 0.308091821684471 3387 1585493 YIL048W NEO1
SGTC_1168 k815-0004 80.5 µM -0.501360266842342 0.316077156355959 no 2351 0.308058798905244 3237 642433
SGTC_685 1278-0033 54.9 µM -0.501443462587345 0.316047703809953 no 2352 0.308029529120213 3405 3590572
SGTC_734 2023-0417 80 µM -0.502805347576748 0.315565742108231 no 2353 0.307550566771387 3361 3935732
SGTC_3289 9119912 71.43 µM -0.503093116509193 0.315463942767335 no 2354 0.307449403036732 3398 17014829
SGTC_2920 7982904 15.77 µM -0.504359530618363 0.315016110531147 no 2355 0.307004375588328 3338 6456808
SGTC_2855 9016525 58.44 µM -0.50468130655339 0.31490236667045 no 2356 0.30689134635508 3335 43811474
SGTC_506 n9-isopropylolomoucine 153 µM -0.505470757066792 0.314623379944656 no 2357 0.306614116296106 3401 6610355
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.507391877392978 0.313944910634996 no 2358 0.305939941909696 3242 688667
SGTC_2248 tofa 1.1 µM -0.507709508311608 0.313832795519212 no 2359 0.305828539641708 3218 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.508709804494968 0.313479830373228 no 2360 0.305477824501738 3320 442882
SGTC_162 k030-0015 37.8 µM -0.509633413405413 0.313154076729142 no 2361 0.305154155206203 3339 1809920 YMR134W ERG29
SGTC_531 3788-1495 174 µM -0.510263533175535 0.312931919310139 no 2362 0.304933423570739 3249 2896655
SGTC_1338 1486-1223 76 µM -0.511152602907927 0.312618581027781 no 2363 0.304622102192662 3346 3444526
SGTC_119 0121-0043 24.815 µM -0.511597069039319 0.312461986855643 no 2364 0.304466518592855 3429 1092378
SGTC_2558 carylophyllene oxide 100 µM -0.511991569717479 0.312323024858113 no 2365 0.304328454832687 3401 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3126 9127922 49.47 µM -0.512771899370801 0.312048234074489 no 2366 0.304055444296099 3443 45595682
SGTC_2974 9094440 9.66 µM -0.513196975349049 0.311898588803643 no 2367 0.303906770759877 3430 25236134
SGTC_2979 9012552 45.46 µM -0.513539624098307 0.311777984107129 no 2368 0.3037869503754 3421 17100905
SGTC_2481 5478948 45.16 µM -0.513722153456034 0.311713746093983 no 2369 0.303723130533399 3408 77792
SGTC_3031 9088762 49.47 µM -0.513814420838364 0.311681276383236 no 2370 0.303690872302524 3270 205253
SGTC_2589 lobaric acid 100 µM -0.515530768176395 0.311077545664862 no 2371 0.30309108739241 3289 73157 A novel microtubule depolymerizer.
SGTC_1142 3253-1408 9.78 µM -0.517680311892465 0.310322153303591 no 2372 0.302340668512499 3415 256655
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.518472939680221 0.310043809728258 no 2373 0.302064167774043 3446 1377
SGTC_563 tetrahydrosecaminediol 614 µM -0.519066372204725 0.309835487892008 no 2374 0.301857228788315 3422 334274 A psychoactive constituent of the cannabis plant.
SGTC_31 0508-1974 57.237 µM -0.51967827059538 0.309620747624972 no 2375 0.301643917213022 3389 6810525
SGTC_2826 7992541 19.48 µM -0.519733665185202 0.309601310595217 no 2376 0.301624609662223 3409 2985066
SGTC_773 4358-1457 44.6 µM -0.520806161780007 0.309225094591017 no 2377 0.30125090511064 3419 1186886
SGTC_2642 cholecalciferol 100 µM -0.52083627741594 0.309214533353893 no 2378 0.301240414521337 3379 9821465 A vitamin D precursor, similar to steriods.
SGTC_1708 st033234 31.827 µM -0.52160533357994 0.308944886871909 no 2379 0.300972574494699 3450 674664
SGTC_2180 6301957 200 µM -0.522153536759268 0.308752738691227 no 2380 0.300781716748037 3395 845462
SGTC_2824 7998404 51.95 µM -0.522293623853754 0.308703645801304 no 2381 0.300732953980325 3303 837851
SGTC_963 1269-2853 151 µM -0.523087576507991 0.308425473289949 no 2382 0.300456655275046 3304 3668223
SGTC_2087 5276107 200 µM -0.52369788857517 0.308211716577923 no 2383 0.300244342213424 3367 144405
SGTC_3330 9141424 71.43 µM -0.52547919502071 0.307588200905104 no 2384 0.299625056255167 3410 27261020
SGTC_2968 9090663 33.37 µM -0.527802342969113 0.306775857617796 no 2385 0.298818265398035 3293 25236811
SGTC_1173 0443-0020 122 µM -0.527907718977541 0.306739032867195 no 2386 0.298781693468785 3327 5331295
SGTC_2898 9056270 58.44 µM -0.528449822276766 0.306549620021257 no 2387 0.298593582579917 3379 19154699
SGTC_2539 epi(13)torulosol 80 µM -0.528729640200447 0.306451870843126 no 2388 0.298496506302797 3392 6708597
SGTC_2048 5246248 200 µM -0.529524697477267 0.306174207561723 no 2389 0.298220758186805 3438 677046
SGTC_2796 7949634 45.45 µM -0.53174239074855 0.305400295996662 no 2390 0.297452213885194 3368 2971588
SGTC_56 0957-0365 83.25 µM -0.53297610014731 0.304970142565058 no 2391 0.29702506231326 3423 6752360
SGTC_452 diindolylmethane 8 µM -0.534022848092698 0.304605387554353 no 2392 0.296662863223724 3408 3071 Inhibits expression of several cancer promoting factors.
SGTC_1634 st006576 41 µM -0.534335502228082 0.304496476182825 no 2393 0.296554716879489 3459 3915356
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.534387790063045 0.304478263690655 no 2394 0.296536632401056 3335 115019
SGTC_2623 humulene 100 µM -0.53485106201667 0.304316921584765 no 2395 0.296376425397774 3388 6187145 An anti-inflammatory.
SGTC_2618 avocadyne 43.43 µM -0.535330359045112 0.304150038561501 no 2396 0.296210718436961 3357 3015189
SGTC_2576 guaiol 23.12 µM -0.535808079682697 0.303983744998105 no 2397 0.296045598782921 3355 227829
SGTC_2124 5246320 200 µM -0.538163235932285 0.303164513232196 no 2398 0.295232179372708 3411 579342
SGTC_1155 4088-0394 48.2 µM -0.538854256876572 0.302924331816503 no 2399 0.294993711224455 3324 2326248
SGTC_166 k072-0058 166.424 µM -0.538998248536221 0.302874294679749 no 2400 0.294944031539702 3454 5846229
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.539009820474863 0.302870273588896 no 2401 0.294940039182328 3336 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1776 st049249 45.9 µM -0.539634639378879 0.302653193037171 no 2402 0.294724511560775 3387 1822314
SGTC_3046 9092212 49.47 µM -0.540296636937494 0.302423271613796 no 2403 0.294496238653089 3405 25236637
SGTC_526 4469-0568 170 µM -0.54134995856953 0.302057599187827 no 2404 0.294133195965717 3397 2901964
SGTC_817 1391-0715 46 µM -0.541932125571786 0.301855578611635 no 2405 0.293932632386538 3357 1353946
SGTC_457 grayanotoxin iii 135 µM -0.542305699215067 0.301725975013295 no 2406 0.293803965066216 3420 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3238 9133470 49.47 µM -0.54244376388794 0.301678082681957 no 2407 0.293756419025924 3461 3534688
SGTC_81 0411-0046 9.971 µM -0.544073106922784 0.301113149186585 no 2408 0.293195582934068 3371 12925265
SGTC_900 1112-0045 141 µM -0.544493798869671 0.300967362363179 no 2409 0.29305085725656 3378 56211 YIL048W NEO1
SGTC_393 acivicin 6.25 µM -0.545727109912524 0.300540153581963 no 2410 0.292626766935063 3318 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2656 pseudo-anisatin 100 µM -0.545758094289415 0.300529424376142 no 2411 0.292616116219498 3400 6708809 A neurotoxin.
SGTC_1609 st001574 46.4 µM -0.546719890260883 0.300196461718847 no 2412 0.292285593545621 3343 3960012
SGTC_1043 0916-0009 19.3 µM -0.547691010065151 0.299860440589118 no 2413 0.291952043011672 3481 3101130
SGTC_2834 9001755 58.44 µM -0.548917066212689 0.299436451257085 no 2414 0.291531182826558 3293 2989575
SGTC_2519 cryptotanshinone 88.04 µM -0.550133847110684 0.299015938396189 no 2415 0.291113786433881 3467 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2900 5328528 85.29 µM -0.551159608308711 0.298661649368051 no 2416 0.290762133124029 3445 795359
SGTC_1723 st034307 2.5525 µM -0.553024387201153 0.298018060292404 no 2417 0.290123355525424 3412 867466
SGTC_2922 7999257 32.47 µM -0.556374349617676 0.296863482012301 no 2418 0.288977485065435 3464 2988377
SGTC_3142 9086498 49.47 µM -0.557607318363245 0.296439050245589 no 2419 0.288556278998919 3384 25236367
SGTC_1431 4049-0260 9.09 µM -0.557627175930572 0.296432216839804 no 2420 0.288549497635814 3437 3854841
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.558887743467516 0.295998576936656 no 2421 0.288119167337152 3348 279621
SGTC_2367 9070478 135.38 µM -0.559113339812177 0.295921001689964 no 2422 0.288042185618057 3436 572802
SGTC_439 amiodarone 34.4 µM -0.560405763382796 0.29547675930663 no 2423 0.287601350681063 3327 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.561982683378818 0.294935143306545 no 2424 0.287063908721717 3367 6708630 An antioxidant.
SGTC_2882 9058044 58.44 µM -0.562563132685192 0.294735894843637 no 2425 0.286866201251428 3420 18076804
SGTC_1814 st052110 31.539 µM -0.563146985980568 0.294535540547967 no 2426 0.286667399462482 3482 674163
SGTC_2490 carminic acid 95.39 µM -0.563239526565434 0.294503790218918 no 2427 0.2866358954333 3441 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1181 1222-0449 220 µM -0.564660834088618 0.294016343475423 no 2428 0.286152239378099 3530 658318
SGTC_2977 9011197 71.43 µM -0.565291929921766 0.293800024658956 no 2429 0.28593760843157 3515 2704722
SGTC_2127 5253358 187.912 µM -0.566779587537651 0.293290396331617 no 2430 0.285431970301179 3380 20612
SGTC_2316 5844804 197.44 µM -0.566914003645574 0.293244369463601 no 2431 0.285386304755349 3455 776813
SGTC_1934 st074720 32.6 µM -0.569043252777099 0.292515717365029 no 2432 0.28466339372821 3454 17250992
SGTC_2592 piperlongumine 83.33 µM -0.569345061556518 0.292412503260182 no 2433 0.284560996043094 3401 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_131 0141-0277 33.849 µM -0.570343270808018 0.292071251240069 no 2434 0.284222448959644 3465 1547771
SGTC_3212 9128307 49.47 µM -0.571249995969816 0.291761435118633 no 2435 0.283915096111347 3271 27243542
SGTC_3100 9120536 49.47 µM -0.571969389766496 0.291515736674128 no 2436 0.283671356243768 3403 16421196
SGTC_1587 estradiol valerate 56.1 µM -0.572427567923909 0.291359302933347 no 2437 0.283516171855788 3506 13791 A steroid.
SGTC_1703 st026983 48.3 µM -0.574075055168632 0.29079713256285 no 2438 0.282958506321408 3508 1104023
SGTC_2330 7979373 200 µM -0.578697096228821 0.289222671610141 no 2439 0.281396787827344 3431 1863007
SGTC_3220 9131269 49.47 µM -0.579566785142087 0.288926867644915 no 2440 0.281103398608268 3521 17722206
SGTC_1629 st005085 44.9 µM -0.580217812059718 0.288705529561169 no 2441 0.280883871679882 3419 24207091
SGTC_2572 astragaloside iv 100 µM -0.581016579163332 0.288434071462269 no 2442 0.28061463988389 3495 45006101 An anti-inflammatory agent.
SGTC_682 0kpi-0099 17 µM -0.583473847626548 0.287599732930362 no 2443 0.279787178709134 3499 1714895 YML126C ERG13
SGTC_1820 st053765 18.6 µM -0.584269912447499 0.287329682727236 no 2444 0.279519365735016 3477 3690829
SGTC_566 0958-0068 16.5 µM -0.587125739932272 0.28636188481022 no 2445 0.278559630750181 3522 6815365
SGTC_1382 3002-2117 298 µM -0.587674289977062 0.286176166575272 no 2446 0.278375467869944 3554 1497314
SGTC_2944 9067346 25.62 µM -0.588211357234669 0.285994391420892 no 2447 0.278195217575332 3477 6473075
SGTC_2215 7188065 200 µM -0.588805948155922 0.285793210903934 no 2448 0.277995727620808 3522 940217
SGTC_1199 1638-0010 4.46 µM -0.58969774414029 0.285491596953273 no 2449 0.277696653940516 3431 3111136
SGTC_1623 st003709 20.3 µM -0.590324250807011 0.285279797058885 no 2450 0.277486642001185 3505 16192618
SGTC_2130 NSC 7 2.4545 µM -0.591732113960888 0.284804121295525 no 2451 0.277014994165148 3492 21448
SGTC_3342 9147791 14.508 µM -0.591929994395549 0.284737293634772 no 2452 0.276948733764044 3491 1838168
SGTC_2076 5212012 200 µM -0.592051232448922 0.284696353135496 no 2453 0.276908140951529 3432 604802
SGTC_1655 st012546 55.1 µM -0.593798767905415 0.284106545728002 no 2454 0.276323356617133 3476 720985 YLR208W SEC13
SGTC_2894 9048625 32.47 µM -0.597243857339281 0.282945514778004 no 2455 0.27517229093272 3589 4092861
SGTC_1080 nisoldipine 24.4 µM -0.598979293027312 0.282361518999553 no 2456 0.274593346538183 3454 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2104 5389443 200 µM -0.599871040635458 0.282061660492963 no 2457 0.274296091845545 3563 2244536
SGTC_289 k017-0060 526 µM -0.604191953630519 0.280610888574248 no 2458 0.272858014952008 3473 5512909
SGTC_1070 indatraline 8.81 µM -0.605422626300251 0.280198344571777 no 2459 0.272449110431494 3506 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1188 1403-0014 4.57 µM -0.607793698143855 0.27940434732081 no 2460 0.271662154718148 3526 9614867
SGTC_2132 5317594 122.667 µM -0.609304256860321 0.278899079366348 no 2461 0.271161393012654 3506 794577
SGTC_2389 9091542 195.52 µM -0.610413558926113 0.278528311387093 no 2462 0.270793944275636 3479 3626624 YOL127W RPL25
SGTC_2112 5488546 200 µM -0.610827239803219 0.278390106099532 no 2463 0.270656978966661 3488 600757
SGTC_1048 3161-0300 24.5 µM -0.611250395075213 0.278248770128631 no 2464 0.270516912590054 3549 2165101
SGTC_1321 1326-2144 215 µM -0.611774084656893 0.278073903651392 no 2465 0.270343619043526 3515 3513030
SGTC_995 3931-2021 34.6 µM -0.613581094641325 0.277470932471842 no 2466 0.269746089765563 3508 730143
SGTC_357 1325-0123 420 µM -0.61390973934529 0.277361337559166 no 2467 0.269637486987744 3528 1098503
SGTC_1445 4239-0156 97.7 µM -0.615125958709526 0.276955942558489 no 2468 0.269235770020316 3593 4008346
SGTC_1213 1315-0166 115 µM -0.616293957617695 0.276566893861556 no 2469 0.268850263046247 3495 768401
SGTC_1172 0370-0043 85 µM -0.61647788018852 0.276505655524823 no 2470 0.268789583266561 3572 376585
SGTC_1699 st031318 29.054 µM -0.617874493610481 0.276040860120292 no 2471 0.268329036781912 3549 5340658
SGTC_3106 9121286 49.47 µM -0.618050049949336 0.275982461816001 no 2472 0.268271173513176 3603 15943471
SGTC_1650 st011916 45.8 µM -0.620261415503805 0.275247377521851 no 2473 0.267542846652333 3556 242528
SGTC_587 k089-0003 57 µM -0.621628220137656 0.27479351781866 no 2474 0.267093180197654 3514 9659696
SGTC_3303 9125618 40.5795 µM -0.623381672114397 0.274211809171876 no 2475 0.266516869531378 3544 22695467
SGTC_865 0488-0499 301 µM -0.623459886793216 0.274185875585596 no 2476 0.266491177212494 3576 9634651
SGTC_219 mitoxanthrone 164.414 µM -0.623640560373912 0.274125974404607 no 2477 0.266431833510037 3512 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2199 6590217 200 µM -0.624904355424553 0.273707152023676 no 2478 0.266016916803305 3486 703109
SGTC_2657 nystatin 74.44 µM -0.626259091576832 0.273258543515471 no 2479 0.265572506978008 3577 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1121 fusaric acid 630.51 nM -0.627068674639448 0.27299063145358 no 2480 0.265307109925325 3526 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2844 9010103 25.97 µM -0.629123299394277 0.272311287938254 no 2481 0.264634168974855 3572 2480525
SGTC_2334 9017922 200 µM -0.629562495661416 0.272166180611538 no 2482 0.264490433933871 3559 3163164
SGTC_229 benomyl 22.8748 µM -0.63024572961116 0.271940521397 no 2483 0.26426691207921 3570 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2990 9074105 71.4286 µM -0.631352347234953 0.271575224135758 no 2484 0.263905083276582 3541 6502001
SGTC_1505 k297-0037 20.6 µM -0.63254461007352 0.27118192882512 no 2485 0.263515534020591 3511 4089396
SGTC_2351 9026858 72.31 µM -0.633779282371374 0.270774943312918 no 2486 0.263112437809096 3515 1409300
SGTC_1316 1272-0050 65.9 µM -0.633823376932622 0.270760414046755 no 2487 0.263098047631663 3582 7340392
SGTC_327 1273-0057 3.96 µM -0.633831854232164 0.270757620800356 no 2488 0.263095281126934 3522 3108138
SGTC_797 k781-0471 270 µM -0.636278250170666 0.269952141821435 no 2489 0.262297539289348 3539 23738129
SGTC_1832 st054113 55 µM -0.637324766607954 0.269607941567867 no 2490 0.261956660960129 3579 1251267
SGTC_478 N-arachidonylglycine 10 µM -0.637865152374056 0.269430294298331 no 2491 0.261780731862486 3523 5283389
SGTC_237 nikkomycin 200 µM -0.638077167172933 0.269360612249298 no 2492 0.261711724448797 3611 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1644 st010134 20.9 µM -0.643026819386503 0.267736402340236 no 2493 0.260103348807864 3581 3818134
SGTC_3019 9081971 49.47 µM -0.643680630214654 0.267522226337197 no 2494 0.259891276454739 3631 16451803
SGTC_925 2064-1272 59.6 µM -0.64425749302838 0.26733332880499 no 2495 0.259704237321632 3534 6815817
SGTC_2955 9076254 12.21 µM -0.645116842067634 0.267052054141542 no 2496 0.259425735152393 3517 16459619
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.645694708165523 0.266862996095953 no 2497 0.259238544181835 3561 5355888
SGTC_2817 7995342 71.43 µM -0.646721223834947 0.266527322076321 no 2498 0.258906192206234 3515 18879975
SGTC_2222 6885208 172.143 µM -0.647077400955326 0.266410900901768 no 2499 0.258790925314194 3563 609514
SGTC_2037 5169046 200 µM -0.647284002939114 0.266343382119393 no 2500 0.258724076457958 3592 5718022
SGTC_1748 st037455 53.6035 µM -0.647374789823887 0.266313715153205 no 2501 0.258694703964868 3597 580690
SGTC_323 4013-0906 34.3 µM -0.647384220868445 0.266310633410999 no 2502 0.258691652815947 3600 2910086
SGTC_2866 9034245 58.44 µM -0.647820004322515 0.266168253997193 no 2503 0.258550687669842 3581 6462273
SGTC_134 0269-0018 6.916 µM -0.647845096674355 0.266160056983589 no 2504 0.258542572127326 3515 4378915
SGTC_2331 7980721 200 µM -0.649063289413538 0.265762259137065 no 2505 0.258148734508722 3570 2981221
SGTC_548 1436-0017 110 µM -0.65043185821702 0.265315716128745 no 2506 0.257706652117296 3643 9677137
SGTC_1367 1812-0510 76.9 µM -0.650459635761971 0.265306656687001 no 2507 0.2576976833379 3574 1142582 YDR527W RBA50
SGTC_2865 9030313 51.95 µM -0.651545072455072 0.26495277250083 no 2508 0.257347345803731 3537 42562754
SGTC_3191 9110352 49.47 µM -0.651819354228791 0.264863386580931 no 2509 0.257258857307223 3585 17122424
SGTC_3245 9134821 49.47 µM -0.652507566764415 0.264639171915647 no 2510 0.25703689655507 3537 17014901
SGTC_807 1315-0151 48 µM -0.653516693057592 0.264310580524863 no 2511 0.256711615627738 3650 4011080
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.65477776152617 0.263900243999076 no 2512 0.256305425330199 3482 88881 An O-methylated flavonoid and antioxidant.
SGTC_281 1672-3440 14.9 µM -0.656819180312375 0.263236679892168 no 2513 0.255648594905862 3605 6833000
SGTC_1317 1273-0028 910 nM -0.660705593222631 0.261975759503302 no 2514 0.254400568072729 3599 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_39 0986-0283 58.349 µM -0.662008769164632 0.261553647206314 no 2515 0.253982800863014 3653 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1143 3454-2408 5.08 µM -0.662305838784526 0.261457472142815 no 2516 0.253887617816902 3579 X1143
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.66319369509728 0.261170140601085 no 2517 0.253603254489739 3662 5024745
SGTC_2009 4012297 12.05 µM -0.666166142976496 0.260209367817503 no 2518 0.252652455514214 3594 45595307
SGTC_2679 rapamycin 1 nM -0.666999370399072 0.259940374193024 no 2519 0.252386267791021 3615 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2902 5787006 60.46 µM -0.667171710396087 0.259884754995107 no 2520 0.252331229499113 3583 591003
SGTC_1674 st016616 23.6 µM -0.668553036413615 0.259439182267029 no 2521 0.25189031959879 3616 625830
SGTC_1526 st051518 75 µM -0.670949095989582 0.25866722505256 no 2522 0.251126479163338 3590 673993
SGTC_3151 9099821 49.47 µM -0.671013086780558 0.258646624954828 no 2523 0.251106096334226 3591 17174189
SGTC_1021 4476-0760 85.3 µM -0.672899042648782 0.258039874294346 no 2524 0.250505760650103 3607 746768
SGTC_1272 0839-0021 27 µM -0.674575545872958 0.257501129288088 no 2525 0.249972736932726 3630 5027250
SGTC_1313 1220-0047 237 µM -0.675203164256147 0.257299594273868 no 2526 0.249773348280013 3655 3528706
SGTC_1622 st003707 19.4 µM -0.675413096046264 0.257232201219655 no 2527 0.24970667371144 3664 10140899
SGTC_2095 5432005 200 µM -0.67773646391517 0.256486958569249 no 2528 0.248969401106767 3647 783734
SGTC_1255 0566-0045 221 µM -0.678108508963131 0.256367726099392 no 2529 0.248851448022025 3666 2788469
SGTC_875 0709-0210 25.7 µM -0.678364336042268 0.256285755763028 no 2530 0.248770357921628 3655 6251364
SGTC_3327 9140648 26.9345 µM -0.678559680499067 0.25622317404867 no 2531 0.248708448612204 3627 8029710
SGTC_2874 9043904 71.43 µM -0.678681872325929 0.256184031997761 no 2532 0.24866972728462 3599 4463428
SGTC_1056 3448-1962 115 µM -0.678696581327019 0.256179320432411 no 2533 0.248665066370654 3634 715507
SGTC_2972 9093619 59.92 µM -0.679707847956894 0.255855501380171 no 2534 0.248344732905197 3638 25236256
SGTC_2057 5236571 38.335 µM -0.680116039296485 0.255724854424901 no 2535 0.248215494684739 3641 54684039 YBR257W POP4
SGTC_552 k242-0005 476 µM -0.680298105414982 0.25566659302674 no 2536 0.248157861959956 3664 4088318
SGTC_3217 9129673 49.47 µM -0.681731396921465 0.255208180036332 no 2537 0.247704405295819 3637 17248312
SGTC_921 1561-0023 372 µM -0.68206222144474 0.255102432732848 no 2538 0.247599803791955 3653 24050882
SGTC_541 4513-1321 94 µM -0.682187515052641 0.255062388901604 no 2539 0.247560194087717 3617 747515
SGTC_1642 st009582 77.7 µM -0.683092598119391 0.254773222090116 no 2540 0.247274166161236 3657 6739311
SGTC_2221 6807166 181.081 µM -0.683543427009548 0.254629249923857 no 2541 0.247131759386155 3606 674925
SGTC_952 1185-0122 232 µM -0.683647274173327 0.25459609238052 no 2542 0.247098962604048 3613 678600
SGTC_3315 9136395 68.55 µM -0.68373235552162 0.254568928292992 no 2543 0.247072094135591 3690 16876844
SGTC_1836 st055642 81 µM -0.686819840284158 0.253584209152076 no 2544 0.246098132770464 3642 8571
SGTC_2795 7780010 54.55 µM -0.68710017064314 0.253494900073029 no 2545 0.246009803353356 3638 953673
SGTC_2782 7736369 71.43 µM -0.688839549112575 0.252941129608264 no 2546 0.24546212220953 3716 2950836 YOL077C BRX1
SGTC_179 1273-0063 6.77 µM -0.689103356793418 0.252857196104559 no 2547 0.245379113877406 3640 3108139
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.689853330864059 0.252618663176955 no 2548 0.245143213427252 3672 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2094 5332512 191.667 µM -0.690487081329172 0.252417188174247 no 2549 0.244943965624473 3691 755774
SGTC_750 4073-0104 132 µM -0.691468872273418 0.252105235259036 no 2550 0.244635467870898 3529 22330957
SGTC_201 4262-0159 12.803 µM -0.69257242533368 0.25175483673428 no 2551 0.244288960025811 3642 1341029
SGTC_781 4335-2806 94.4 µM -0.693925307918196 0.251325622598608 no 2552 0.243864525704161 3762 845254
SGTC_625 k213-0058 121 µM -0.694098126254748 0.251270822309773 no 2553 0.243810336792833 3724 3655420
SGTC_2428 5615643 7.78 µM -0.695197886735252 0.250922238926402 no 2554 0.243465648260531 3680 2253075
SGTC_3283 9109332 35.8195 µM -0.695259136791988 0.250902832451574 no 2555 0.243446458920835 3565 17027281
SGTC_1654 st012436 41.8 µM -0.696236155226594 0.250593381256275 no 2556 0.243140474382225 3630 4323132
SGTC_2703 st077852 53.4 µM -0.696896822888586 0.250384242531172 no 2557 0.242933683106782 3657 6281836
SGTC_2188 6126565 140.678 µM -0.698101026015969 0.250003282183374 no 2558 0.242557008243754 3625 874518
SGTC_2134 5324836 1.464 µM -0.698123812658521 0.249996076392992 no 2559 0.242549883630083 3645 699272
SGTC_662 k832-1615 104 µM -0.698358590154334 0.249921839428352 no 2560 0.242476483235072 3680 5878478
SGTC_505 gw-5074 63.9 µM -0.698872652183081 0.249759333178013 no 2561 0.242315809871779 3698 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2276 7947513 42.08 µM -0.69889004922576 0.249753834574034 no 2562 0.242310373324726 3561 2105100
SGTC_567 1080-0542 68.4 µM -0.6997138442209 0.249493535049754 no 2563 0.242053014439164 3609 5950415
SGTC_2975 9084847 53.72 µM -0.700341836831849 0.249295201274623 no 2564 0.241856925099488 3707 27211724
SGTC_2010 4012422 159 µM -0.70095243818698 0.249102440443425 no 2565 0.24166634881596 3672 952393
SGTC_2693 st077581 40.7 µM -0.702525108935214 0.248606329101404 no 2566 0.241175874297295 3713 25238761
SGTC_257 daunorubicin 18.5 µM -0.703384730583253 0.248335377335953 no 2567 0.240908009868473 3718 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3072 9116419 49.47 µM -0.703497598818763 0.24829981309209 no 2568 0.240872851319197 3665 17170162
SGTC_2426 5582046 32.21 µM -0.703783164079912 0.248209844964753 no 2569 0.240783909969501 3674 2251934
SGTC_2066 5222451 176 µM -0.705156834760383 0.247777309260387 no 2570 0.240356320222102 3689 2281147
SGTC_1330 1469-0054 61.8 µM -0.705310136892583 0.247729063097663 no 2571 0.240308626726599 3695 7102664
SGTC_1685 st024049 53.0905 µM -0.705568046450262 0.247647906945985 no 2572 0.240228400676109 3677 1941139
SGTC_1569 carminic acid 40.6 µM -0.70578941009212 0.247578261988419 no 2573 0.240159554339219 3707 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1419 3993-2473 62.6 µM -0.706013110004071 0.247507892629088 no 2574 0.240089992324963 3738 704026
SGTC_2217 6934799 96.0675 µM -0.706478768802632 0.247361444461803 no 2575 0.239945225698549 3628 675606
SGTC_2404 5161160 200 µM -0.709203748655088 0.246505376606724 no 2576 0.239099023782895 3654 2831543
SGTC_41 0478-0632 82.643 µM -0.709240310829055 0.246493901194581 no 2577 0.239087681044719 3682 3750424
SGTC_1715 st032160 10.2275 µM -0.710036083475187 0.246244210738091 no 2578 0.238840880180709 3613 5289825
SGTC_1355 1499-0035 1.68 µM -0.710680794650742 0.246042018488511 no 2579 0.238641031730788 3700 1548538
SGTC_3127 9126946 49.47 µM -0.711437929002874 0.245804682204359 no 2580 0.23840645107789 3668 27243249
SGTC_3310 9130229 44.1445 µM -0.712378630636889 0.245509975008169 no 2581 0.238115172312535 3736 7761258
SGTC_989 1501-0895 10.3 µM -0.712439168568507 0.245491015918805 no 2582 0.238096434034526 3684 2830112
SGTC_3057 9095946 49.47 µM -0.713187461825967 0.245256732629587 no 2583 0.237864881911712 3712 24540043
SGTC_1807 st050092 58.9 µM -0.713821269839344 0.245058387612616 no 2584 0.23766885277417 3684 5008496
SGTC_379 3970-0972 5.9 µM -0.714915079221947 0.244716291983241 no 2585 0.23733075936126 3711 2898042 YBL034C STU1
SGTC_504 lovastatin 124 µM -0.71508375825673 0.244663559467338 no 2586 0.237278644659706 3679 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2475 5812728 15.03 µM -0.715779430096639 0.244446142894185 no 2587 0.2370637778538 3688 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_174 3553-0389 74.3 µM -0.715946990907501 0.244393791095407 no 2588 0.237012040618882 3669 738071
SGTC_3274 9138298 49.47 µM -0.717804544649444 0.243813831953402 no 2589 0.236438905400395 3673 17015756
SGTC_2518 prenyletin 46.28 µM -0.719025361705574 0.243433077480755 no 2590 0.236062646660038 3646 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_412 gemfibrozil 100 µM -0.719194524359857 0.243380343547229 no 2591 0.236010536360631 3681 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1964 st076914 61 µM -0.719225967708292 0.243370542232868 no 2592 0.236000850983439 3737 24208661
SGTC_2762 leflunomide 42.06 µM -0.722610444496278 0.242316803441562 no 2593 0.234959624807237 3695 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2877 9040724 71.43 µM -0.722658913024583 0.242301731002241 no 2594 0.234944732039421 3687 6463895
SGTC_2956 9076196 2.52 µM -0.723316062739818 0.242097424852491 no 2595 0.234742863261111 3744 16423868
SGTC_183 3914-0051 30.55 µM -0.723642063796304 0.241996106639747 no 2596 0.234642755110339 3709 1596232
SGTC_1387 3342-1166 1.8 µM -0.724910323960537 0.241602161584843 no 2597 0.234253523438716 3713 3418228
SGTC_2719 novobiocin 32.65 µM -0.726219674092923 0.241195818802538 no 2598 0.233852056429968 3706 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2854 9024559 71.43 µM -0.727677922922194 0.240743704488042 no 2599 0.233405383909377 3724 3163529
SGTC_402 epigallocatechin gallate 10 µM -0.728173834555919 0.240590057591646 no 2600 0.233253590389947 3695 65064 An antioxidant.
SGTC_2907 7721985 69.9 µM -0.72824494058876 0.240568031387951 no 2601 0.233231830046747 3698 3267881
SGTC_1361 1608-0041 5.61 µM -0.728521518021363 0.240482367652049 no 2602 0.233147200688698 3690 X1361
SGTC_936 3005-4620 401 µM -0.730929912682003 0.239737123334893 no 2603 0.2324109819804 3732 777207
SGTC_2356 9061756 188.97 µM -0.73469661076353 0.238574101943833 no 2604 0.231262142446356 3728 20104043
SGTC_2116 5511452 16.8835 µM -0.737147188143372 0.237819112736379 no 2605 0.230516422761474 3750 870744
SGTC_2487 5918373 44.05 µM -0.737797340534939 0.23761902988094 no 2606 0.230318804821131 3751 2876279
SGTC_1792 st045773 43.6 µM -0.738104128101488 0.237524648821795 no 2607 0.230225587704069 3660 2919270
SGTC_3304 9125678 46.087 µM -0.738907256676798 0.237277669371175 no 2608 0.229981657790258 3728 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2802 7925815 54.55 µM -0.740347276632109 0.236835185397884 no 2609 0.229544650695023 3754 1262923
SGTC_1293 1000-1278 195 µM -0.741774623154953 0.236397043790849 no 2610 0.229111949164703 3786 678847
SGTC_1689 st020265 53.493 µM -0.742092876464642 0.236299412886152 no 2611 0.229015532769933 3733 5758320 YPR016C TIF6
SGTC_1887 st057648 70.8 µM -0.743147710262397 0.235975979204571 no 2612 0.228696128535942 3773 688672
SGTC_2055 5235184 200 µM -0.743229585695817 0.235950884724345 no 2613 0.228671347076485 3761 2836034
SGTC_1711 st032263 62.8 µM -0.745965294284507 0.23511324751716 no 2614 0.227844190161429 3769 3958979
SGTC_441 propafenone 146 µM -0.746052637867116 0.235086531169688 no 2615 0.227817809101012 3716 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2371 9071574 200 µM -0.746404386297873 0.234978956574965 no 2616 0.227711585193305 3721 45596039
SGTC_2765 myclobutanil 7.74 µM -0.746693698231466 0.234890497211824 no 2617 0.227624237276277 3774 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1357 1503-1303 39.5 µM -0.747160221927719 0.234747892754414 no 2618 0.227483426027029 3744 292895
SGTC_2488 5268135 45.7 µM -0.747423009008108 0.234667586490399 no 2619 0.227404130381936 3795 1270356 YLR208W SEC13
SGTC_490 phenamil 164 µM -0.747821560928398 0.234545820246476 no 2620 0.22728389760129 3723 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3193 9111931 49.47 µM -0.749408939842013 0.234061188583414 no 2621 0.226805382161681 3798 17087244
SGTC_378 3970-0959 8.33 µM -0.751094008142704 0.233547339472946 no 2622 0.226298040759293 3776 6615653
SGTC_491 tetrandrine 80.3 µM -0.751157561447004 0.233527971613365 no 2623 0.226278918644917 3724 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_534 k292-0788 63.4 µM -0.752543711731043 0.233105764194857 no 2624 0.225862076606185 3779 4146317
SGTC_822 1487-0950 154 µM -0.752682336536541 0.233063563798898 no 2625 0.225820413361112 3745 1958375
SGTC_2388 9080168 200 µM -0.753803788333396 0.232722325579583 no 2626 0.225483524441492 3733 15943073
SGTC_435 c-PAF 6.7 µM -0.754018779579818 0.232656939226302 no 2627 0.225418972663139 3783 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_512 prima-1 270 µM -0.7552588944046 0.232279976360851 no 2628 0.22504682868887 3771 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1349 flufenamic acid 69 µM -0.755528567041737 0.23219804785427 no 2629 0.224965949189119 3727 3371 A non-steroidal anti-inflammatory.
SGTC_1744 st037937 38.9 µM -0.75558255396653 0.232181648166455 no 2630 0.224949759553708 3802 1016152
SGTC_1885 st057546 99.9 µM -0.756122767115634 0.23201758232289 no 2631 0.224787796439117 3837 702008
SGTC_1391 3442-0225 151 µM -0.756131183110058 0.232015026847662 no 2632 0.224785273734822 3722 5227075
SGTC_2437 5741531 144.16 µM -0.75709026236222 0.23172390983131 no 2633 0.224497893767119 3794 2262990
SGTC_251 melphalan 456.522 µM -0.757314925661693 0.231655745412129 no 2634 0.22443060546421 3820 460612 A DNA alkylator.
SGTC_2917 7979103 53.79 µM -0.757348782649309 0.231645473933832 no 2635 0.22442046604109 3810 2980565
SGTC_601 0986-0029 62.9 µM -0.757388404415479 0.231633453868637 no 2636 0.224408600523745 3743 24747981
SGTC_1282 0886-0010 32.4 µM -0.758363016995254 0.231337894865313 no 2637 0.224116845733083 3834 2836211 YNL267W PIK1
SGTC_2152 5568786 200 µM -0.758461658061384 0.231307992904772 no 2638 0.224087329083498 3741 5399883
SGTC_1454 4239-0054 42.6 µM -0.75891358574618 0.231171023537163 no 2639 0.223952125700292 3896 1340767
SGTC_3201 9113999 49.47 µM -0.759134205316385 0.231104175027354 no 2640 0.223886139697188 3804 16649224
SGTC_368 fentichlor 4.58 µM -0.759825990766006 0.230894631554804 no 2641 0.223679302434736 3785 7329 A pesticide.
SGTC_3338 9144300 39.5675 µM -0.76104876549932 0.230524509767213 no 2642 0.223313970312305 3799 4901274
SGTC_1185 1319-0113 81.3 µM -0.761515650946249 0.230383275697099 no 2643 0.223174567162346 3818 4672763
SGTC_597 k018-0003 82.8 µM -0.761713898058665 0.230323320062042 no 2644 0.223115389317535 3862 6786234
SGTC_838 0109-0203 71.4 µM -0.762734915027963 0.230014673352512 no 2645 0.222810751720427 3787 759422
SGTC_3223 9129970 49.47 µM -0.76438529961987 0.229516262756055 no 2646 0.222318833233169 3830 17248386
SGTC_302 1094-0063 18.9 µM -0.765855574003594 0.229072754997404 no 2647 0.221881121256749 3732 5440289
SGTC_1336 1486-0901 104 µM -0.765882785082098 0.229064551318636 no 2648 0.22187302495118 3799 5006114
SGTC_3030 9087619 49.47 µM -0.765883313082076 0.229064392137225 no 2649 0.221872867853262 3797 25236973
SGTC_1796 st049173 110.4 µM -0.766278307993592 0.228945326477287 no 2650 0.221755361260274 3721 94134
SGTC_970 1315-0089 19.5 µM -0.766597368072476 0.228849175665893 no 2651 0.221660470398727 3736 6811083 YLR033W RSC58
SGTC_1756 st041558 35.5 µM -0.766654714970075 0.228831896211926 no 2652 0.221643417461348 3827 3955792
SGTC_843 0310-0051 143 µM -0.767060516703459 0.228709643178528 no 2653 0.221522767814934 3806 2065037
SGTC_3079 9117512 49.47 µM -0.767103563310305 0.22869667698184 no 2654 0.221509971753187 3808 7185044
SGTC_1661 st013063 9.66 µM -0.768264945602925 0.228347009389027 no 2655 0.22116489802721 3827 721395
SGTC_2261 9010538 184.68 µM -0.770535850832607 0.227664156857111 no 2656 0.220491048587114 3737 6457250
SGTC_1874 staurosporine 7.6 µM -0.770748263616041 0.227600343989739 no 2657 0.220428079221435 3827 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2105 5350118 200 µM -0.77203219853687 0.227214839840774 no 2658 0.22004767866519 3798 2133313
SGTC_561 1550-0330 72.9 µM -0.775397250814381 0.226206224022831 no 2659 0.219052479565376 3743 6812934
SGTC_3227 9130768 49.47 µM -0.776712892187152 0.225812572378231 no 2660 0.218664089459217 3819 17720899
SGTC_1 0258-0098 57.368 µM -0.779165161307745 0.225079866705367 no 2661 0.217941214796583 3735 6790032 YDR047W HEM12
SGTC_1733 st037357 54.9 µM -0.77928322721014 0.225044624193273 no 2662 0.217906446385135 3730 1272339 YGL099W LSG1
SGTC_2393 9031399 185.94 µM -0.779545066270641 0.22496647674624 no 2663 0.217829350623888 3817 1526623 YDL150W RPC53
SGTC_91 0417-1751 58.384 µM -0.779709957633933 0.224917271817936 no 2664 0.217780808168181 3891 6795624
SGTC_1039 k821-0043 94 µM -0.780955589038035 0.224545762410321 no 2665 0.217414307752627 3759 15992768
SGTC_316 k060-0003 58.6 µM -0.781555287089962 0.224367026775514 no 2666 0.217237986485411 3780 6152314
SGTC_973 1325-0077 65.9 µM -0.782849768337434 0.223981491495401 no 2667 0.216857669013892 3831 2835149
SGTC_2678 equilin 100 µM -0.783144594672694 0.223893736038392 no 2668 0.216771103140932 3806 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2825 7998094 58.44 µM -0.783264546026697 0.223858037948493 no 2669 0.216735889165105 3806 2987815
SGTC_608 k048-0125 159 µM -0.784976509521545 0.223348902191768 no 2670 0.21623367073133 3825 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1318 1280-3875 124 µM -0.785969691547385 0.22305383340989 no 2671 0.215942621797225 3824 373245
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.786700729566376 0.222836788041267 no 2672 0.215728538453775 3784 390807
SGTC_3264 9137442 49.47 µM -0.787376571008742 0.222636237642885 no 2673 0.215530728836968 3786 17015726
SGTC_904 1141-0088 396 µM -0.787485694494147 0.222603865795102 no 2674 0.215498799740572 3822 1378119
SGTC_1970 st070122 35.8 µM -0.787856418816162 0.222493909227979 no 2675 0.215390347777647 3812 102928
SGTC_551 k048-0028 34.9 µM -0.78841097298117 0.222329486693662 no 2676 0.215228177223424 3781 6836383
SGTC_1326 1431-2094 10.8 µM -0.788668066191875 0.222253283366982 no 2677 0.2151530184477 3797 616278
SGTC_1902 st060212 70.5 µM -0.790295945707575 0.221771120254694 no 2678 0.214677477001017 3822 688944
SGTC_826 1683-5028 118 µM -0.79152228244968 0.221408285440053 no 2679 0.214319639285132 3886 722377
SGTC_3226 9131256 49.47 µM -0.791843121002222 0.221313415360144 no 2680 0.214226077805151 3696 17178073
SGTC_2320 7373003 200 µM -0.793345797984551 0.22086939213388 no 2681 0.213788190363606 3883 5415828
SGTC_245 methotrexate 289.6 µM -0.793512231720345 0.220820244332233 no 2682 0.213739722842168 3821 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2257 7960413 200 µM -0.793913200372919 0.220701864203152 no 2683 0.213622982195677 3804 2974689 YIL048W NEO1
SGTC_2873 9040596 71.43 µM -0.79428215342108 0.22059296833168 no 2684 0.213515595607211 3784 6463863
SGTC_2521 angolensin 13.4 µM -0.794870532986087 0.220419372796626 no 2685 0.213344408365665 3888 821428 A flavenoid.
SGTC_329 k048-0121 21.3 µM -0.796435808108022 0.219957935368799 no 2686 0.21288938611072 3833 6832902
SGTC_955 1216-0110 33 µM -0.796659611174307 0.2198920043589 no 2687 0.21282437333267 3791 3619719
SGTC_3085 9117376 49.47 µM -0.798962773378521 0.219214166152469 no 2688 0.212155999019112 3935 16480349
SGTC_2044 5102272 200 µM -0.800359211494245 0.218803769350436 no 2689 0.21175135300056 3842 592666
SGTC_3061 glucosamine 200 µM -0.800456974009222 0.218775054660974 no 2690 0.211723041272715 3730 91431 and experimental redox chemotherapeutic
SGTC_1405 3909-7894 12 µM -0.800759546235663 0.218686197250032 no 2691 0.21163543131304 3846 7104060
SGTC_1137 ixabepilone 100 µM -0.800898373059115 0.218645434459445 no 2692 0.211595241030556 3816 154225 A novel microtubule stabilizer.
SGTC_2321 7390090 138.78 µM -0.801235707540349 0.218546403422644 no 2693 0.211497601520504 3850 649046
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.802229763754513 0.218254729295592 no 2694 0.211210031171951 3775 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_404 fumagillin 50 µM -0.803513589620703 0.217878363591999 no 2695 0.210838972633926 3822 12015870 A methionine aminopeptidase binder.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.804805546119654 0.217499992448511 no 2696 0.210465950353406 3867 229346 A bile salt which induces apoptosis.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.807353103998001 0.216755009757491 no 2697 0.209731538545526 3902 641818
SGTC_2185 6113692 200 µM -0.807873058517512 0.216603140906133 no 2698 0.209581831049528 3824 874150
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.808013192318407 0.216562221014058 no 2699 0.209541493890416 3832 6857784
SGTC_514 4466-0038 2.65 nM -0.809885753366825 0.216015851530112 no 2700 0.209002920319621 3749 5722064
SGTC_1102 cgs 12066b 26.1 µM -0.810249076583845 0.21590993489293 no 2701 0.208898518229078 3853 6438352 A 5-HT1B full agonist.
SGTC_1617 st002906 78 µM -0.811340324086626 0.215591993441794 no 2702 0.208585129537732 3854 5150859
SGTC_2013 4024628 200 µM -0.81260803457642 0.215222979569966 no 2703 0.208221411771785 3871 5230760
SGTC_2541 muurolladie-3-one 83.07 µM -0.813293734741338 0.215023534123229 no 2704 0.208024834156015 3887 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_788 1182-0090 188 µM -0.814563128333922 0.214654596687685 no 2705 0.207661211642928 3955 5715185
SGTC_2489 cantharidin 73.42 µM -0.814977758342357 0.214534168091697 no 2706 0.207542520746663 3810 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2160 5660466 132.927 µM -0.815634685067999 0.214343445254387 no 2707 0.207354552729525 3782 2859134
SGTC_1938 st074717 56.4 µM -0.817545567405185 0.213789227584971 no 2708 0.20680835990603 3705 17250979
SGTC_611 3453-1652 23.7 µM -0.818111227224214 0.213625328174321 no 2709 0.206646839305867 3823 1560575
SGTC_627 1391-0720 175 µM -0.818273960938327 0.213578189793935 no 2710 0.20660038555953 3856 997839
SGTC_1034 k072-0165 12.7 µM -0.8195974896212 0.213195034044991 no 2711 0.206222802611246 3877 5835461
SGTC_622 1348-1566 26.3 µM -0.819873114241022 0.213115292390139 no 2712 0.206144222521989 3910 7340407
SGTC_1483 3453-0561 55.9 µM -0.820523069987239 0.212927320951701 no 2713 0.205958991598138 3877 4546991
SGTC_1254 0550-0035 264 µM -0.822882254236893 0.212245842960618 no 2714 0.205287477547265 3956 15121435
SGTC_2213 7173844 200 µM -0.823493562781973 0.212069467522998 no 2715 0.205113688166458 3837 892728
SGTC_912 3474-0017 2.18 µM -0.82368552974835 0.212014098683054 no 2716 0.205059131773327 3900 3360550
SGTC_2992 9074591 71.4286 µM -0.82486216395536 0.211674908026111 no 2717 0.204724924614817 3830 17741321
SGTC_2211 7117706 200 µM -0.825855440634351 0.21138882159145 no 2718 0.204443050059671 3780 822771
SGTC_2318 6029776 164 µM -0.826516439467116 0.211198564348685 no 2719 0.204255598224891 3844 818325
SGTC_1085 doxorubicin 7.67 µM -0.826819911686816 0.211111248663719 no 2720 0.204169571207509 3867 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_12 0849-0099 9.267 µM -0.828785990635726 0.210546076910583 no 2721 0.203612758456012 3768 6071388
SGTC_1935 st074532 41.6 µM -0.83140744371574 0.209793893310502 no 2722 0.202871747691989 3895 2829742
SGTC_428 3448-4153 16.5 µM -0.831920462733204 0.209646875843046 no 2723 0.20272692040425 3848 3834874
SGTC_3052 9092717 49.47 µM -0.832254897591886 0.209551068428852 no 2724 0.202632541400561 3877 25237534
SGTC_646 4092-0839 27.3 µM -0.833486009318831 0.20919860697669 no 2725 0.202285342528356 3932 877796
SGTC_270 tamoxifen 5.46 µM -0.833630162640609 0.209157359401577 no 2726 0.20224471160674 3914 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2440 5628896 157.78 µM -0.834531875070046 0.208899454935442 no 2727 0.201990666575833 3896 5522048
SGTC_1901 st060216 58.6 µM -0.834583174595196 0.208884788068854 no 2728 0.201976219387286 3872 688792
SGTC_1253 0550-0034 176 µM -0.836099175525038 0.208451627517937 no 2729 0.201549556087096 3906 5969915
SGTC_3288 9119690 36.221 µM -0.836216000803488 0.208418269521615 no 2730 0.201516699206349 3886 17595618 YKL019W RAM2
SGTC_918 glabranin 770.725 nM -0.836890545482617 0.208225723308365 no 2731 0.201327047609985 3917 124049 Also referred to as licorice root.
SGTC_3152 9099253 49.47 µM -0.838281496158193 0.207829013246413 no 2732 0.200936312835689 3840 25236131
SGTC_3097 9117246 49.47 µM -0.838494317821905 0.207768354233036 no 2733 0.200876568828937 3892 16423892
SGTC_286 k060-0067 22.9 µM -0.840626291967008 0.207161270445983 no 2734 0.200278662371351 3878 5985051
SGTC_2231 micatex 6.853 µM -0.845194410796111 0.205864027706863 no 2735 0.199001151222382 3931 20737 An antifungal of unknown mechanism.
SGTC_654 1124-0271 80.9 µM -0.845274671485115 0.205841278646587 no 2736 0.198978749660095 3894 5403748
SGTC_2810 7959871 45.46 µM -0.846045713593536 0.205622810752827 no 2737 0.198763621516668 3892 2974535
SGTC_3339 9145883 14.936 µM -0.847635122486231 0.205172900465993 no 2738 0.198320603893487 3816 2030670
SGTC_1948 st076329 66.6 µM -0.848636528270341 0.204889735476631 no 2739 0.198041787258963 3780 24208413
SGTC_3266 9136860 49.47 µM -0.850094633973119 0.20447784635974 no 2740 0.197636237366507 3789 4871271 YPR165W RHO1
SGTC_2150 5556613 200 µM -0.850994596434624 0.204223868987157 no 2741 0.197386177228928 3912 743190
SGTC_3130 9127414 49.47 µM -0.853212579186918 0.203598737166437 no 2742 0.196770714407402 3902 1494646
SGTC_2006 4011487 200 µM -0.85362175501382 0.203483536985541 no 2743 0.196657300276729 3961 45595294
SGTC_1726 st035556 14.5795 µM -0.85507270120255 0.203075348202096 no 2744 0.196255450625571 4042 5919439
SGTC_1996 st072960 66.8 µM -0.855085630405488 0.203071713081125 no 2745 0.196251872032153 3889 1719405
SGTC_291 SEC14.278 35.5 µM -0.857704955388112 0.202336076038214 no 2746 0.195527701529849 3917 1068044
SGTC_3081 9117243 49.47 µM -0.858568053568143 0.202094024586153 no 2747 0.195289434795415 3940 45595589
SGTC_370 0180-0345 38.7 µM -0.860661477405382 0.201507654893486 no 2748 0.194712257869151 3807 3989527
SGTC_3044 9093193 49.47 µM -0.860911322402888 0.20143774126788 no 2749 0.194643442605991 3919 25236277
SGTC_1023 4482-3888 16 µM -0.862682173805097 0.200942624258368 no 2750 0.194156118048417 3925 3303168
SGTC_2984 9022109 38.96 µM -0.867617619986 0.199566568213745 no 2751 0.192801848649669 3959 6459207
SGTC_1247 0448-0043 5.84 µM -0.867769706496109 0.199524255110097 no 2752 0.192760208500573 3978 3089013 YGL099W LSG1
SGTC_1469 k284-2957 126 µM -0.868870964419913 0.199218027205426 no 2753 0.192458856287313 3891 23884841
SGTC_2001 4023502 57.655 µM -0.869848449865005 0.198946454122236 no 2754 0.192191615063984 3957 108941 YCR052W RSC6
SGTC_2088 5278280 127.392 µM -0.87176315529576 0.19841514180112 no 2755 0.191668799305015 3996 791502
SGTC_1008 4106-0037 6 µM -0.87194986251339 0.198363378199362 no 2756 0.191617865019164 3879 2905394
SGTC_2419 paclitaxel 166.5 µM -0.872429113429688 0.198230545694453 no 2757 0.19148716189719 3864 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1135 dihydrocapsaicin 536.708 nM -0.874306625212575 0.19771067893825 no 2758 0.190975646148663 3858 107982 A Capsaicinoid.
SGTC_1611 st001856 99.4 µM -0.875226241939028 0.197456345926947 no 2759 0.190725408694574 3917 647478
SGTC_1409 3909-8004 61.9 µM -0.87542881371236 0.197400348438419 no 2760 0.190670313825814 3947 2119279
SGTC_1071 trifluoperazine 6.31 µM -0.877066505498721 0.196947989425737 no 2761 0.190225258081493 4048 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2242 6630449 61.2675 µM -0.878250194964844 0.196621424795518 no 2762 0.189903978771516 4016 691249 YDR170C SEC7
SGTC_1117 retinoic acid 1.10837 µM -0.879321324141245 0.196326197001043 no 2763 0.189613538506676 3964 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2332 7982454 138.89 µM -0.879321789634278 0.196326068758919 no 2764 0.189613412346114 3894 2981748
SGTC_2515 chrysin 20.77 µM -0.880177695919471 0.196090354690288 no 2765 0.189381527117462 3961 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3290 9121031 71.43 µM -0.880343412532455 0.196044736665284 no 2766 0.189336650749791 3958 17014854
SGTC_958 1222-0007 33 µM -0.881821453849715 0.195638150228271 no 2767 0.188936684017108 4032 7312461
SGTC_45 0kpi-0036 14.9 µM -0.883381267607715 0.195209625125472 no 2768 0.188515154176724 3985 2795021
SGTC_658 3253-0951 102 µM -0.885359070150199 0.194667087554286 no 2769 0.187981500110046 3953 1184878
SGTC_1420 4'-methoxyflavone 42 µM -0.888200813912065 0.193889167351643 no 2770 0.187216370529733 3927 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2190 6049624 200 µM -0.888726377798414 0.193745503443527 no 2771 0.187075075595314 3832 2265554
SGTC_599 1935-0052 86.5 µM -0.890370493794833 0.193296500374703 no 2772 0.186633490225689 3962 9557311
SGTC_887 0885-0007 9.62 µM -0.890542527031903 0.193249555348852 no 2773 0.186587321955717 4045 5719458
SGTC_132 0417-1715 25.805 µM -0.891355600291337 0.193027775277206 no 2774 0.186369214564972 3900 6769098
SGTC_144 4161-2749 112.381 µM -0.892040846124312 0.192840983130558 no 2775 0.186185519659993 3872 797501 YMR168C CEP3
SGTC_629 3448-6466 76.7 µM -0.893437339956475 0.192460652836922 no 2776 0.185811506914791 3960 573744
SGTC_455 paf C-16 10 µM -0.89418220389165 0.192257979377939 no 2777 0.185612206148465 3934 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_724 3910-0327 137 µM -0.894719374450476 0.192111899216837 no 2778 0.185468559562967 4010 2885483
SGTC_1153 4055-0057 267 µM -0.89798332805359 0.19122574829586 no 2779 0.184597218907932 4006 882706
SGTC_1436 4092-1007 8.32 µM -0.89837625630261 0.191119239024156 no 2780 0.184492495253439 3949 2881121
SGTC_698 k064-0052 127 µM -0.898873035484564 0.190984631432241 no 2781 0.184360146042971 4023 5088751
SGTC_2339 9000433 200 µM -0.90051327679833 0.190540603753728 no 2782 0.183923581508186 3989 2988954
SGTC_1553 gossypol 38.6 µM -0.900834202313041 0.190453800601991 no 2783 0.183838239745857 3826 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2162 5663267 200 µM -0.900943291932682 0.190424299838203 no 2784 0.183809235827335 3937 6456493
SGTC_742 0kpi-0133 140 µM -0.903538728866412 0.189723251802579 no 2785 0.183120021597839 4033 2728852
SGTC_3352 9151559 45.5865 µM -0.90518634352001 0.18927904284258 no 2786 0.182683337736359 3976 17159339
SGTC_171 k064-0041 9.68 µM -0.905632338238376 0.189158909611072 no 2787 0.182565243190735 3990 53325
SGTC_569 4130-2812 160 µM -0.906486323617803 0.188929010990775 no 2788 0.182339250246337 3789 743552
SGTC_2525 harmine 47.85 µM -0.906667935453155 0.188880142066971 no 2789 0.182291212261086 3976 5280953 A monoamine oxidase inhibitor
SGTC_2251 lansoprazole 556 µM -0.907604051285629 0.188628371398385 no 2790 0.182043726555148 3898 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_643 k048-0106 28.4 µM -0.9077388515313 0.188592133588168 no 2791 0.182008106039441 3991 6763920
SGTC_1031 k035-0009 16 µM -0.907967367930265 0.188530712246154 no 2792 0.181947731299314 4054 5180959
SGTC_1504 k297-0033 30 µM -0.910158369807694 0.187942434290156 no 2793 0.181369497676476 3896 4388117
SGTC_320 4092-0846 5.34 µM -0.912352580968103 0.187354431832427 no 2794 0.180791571555137 3959 1359356
SGTC_2425 5628681 7.85 µM -0.913561490617209 0.187030955901162 no 2795 0.180473654569274 4047 5714958
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.914106114977338 0.186885340121908 no 2796 0.180330544841266 3982 6708739 YPR165W RHO1
SGTC_290 2043-6722 48.1 µM -0.917093087760182 0.186087963712634 no 2797 0.179546931432256 4007 773758 YLR208W SEC13
SGTC_1878 temozolomide 1 mM -0.917173590343592 0.186066502665085 no 2798 0.179525841749291 3880 5394 DNA alkylating agent.
SGTC_274 sirtinol 40.1 µM -0.918193954082213 0.185794618605006 no 2799 0.179258666673989 4055 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3298 9116858 71.43 µM -0.918814555010384 0.185629375115533 no 2800 0.179096289042827 4047 2506942
SGTC_2852 9023854 51.95 µM -0.919109815415175 0.185550790015318 no 2801 0.179019067890577 4076 19798528
SGTC_2655 perillic acid 100 µM -0.920623849312365 0.185148146429936 no 2802 0.17862342311379 4017 5702197 An apoptosis inducer.
SGTC_756 0508-1999 28.3 µM -0.921634587775283 0.184879652013267 no 2803 0.178359605387018 3998 6753853
SGTC_2986 9022445 71.43 µM -0.927852613134067 0.183233212604348 no 2804 0.176742013975186 4022 6459286
SGTC_2073 5212005 126 µM -0.930889029649755 0.182432548682585 no 2805 0.175955484912309 3799 691789
SGTC_1417 3966-0327 90.4 µM -0.931234229577364 0.182341662473719 no 2806 0.175866207605137 4093 651118
SGTC_287 k060-0039 29.6 µM -0.93140532580573 0.182296625769534 no 2807 0.175821968490704 4059 5861974
SGTC_1314 1222-0010 41.1 µM -0.931826650213801 0.182185752536798 no 2808 0.175713059738739 4016 3526027
SGTC_1946 st076057 65.1 µM -0.93386828714454 0.181649084639098 no 2809 0.175185919602455 3934 953009
SGTC_1548 st061468 90.8 µM -0.934443413992401 0.181498084652157 no 2810 0.175037606067866 3997 390799
SGTC_508 roscovitine 141 µM -0.935770000012217 0.181150088227095 no 2811 0.17469581036466 4075 160355 A CDKinase inhibitor.
SGTC_110 0850-0284 111.64 µM -0.940176666598851 0.179997113113059 no 2812 0.173563474189595 3814 3906265
SGTC_2664 lyso-paf C-16 73.48 µM -0.942060615404409 0.179505599631805 no 2813 0.173080803517313 3991 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2644 guaiazulene 100 µM -0.942469889112181 0.179398933673743 no 2814 0.172976060100771 4027 3515 A coloring agent.
SGTC_2675 theaflavin digallate 100 µM -0.943692576535068 0.179080511171924 no 2815 0.172663384299581 3973 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1773 st048542 73.5835 µM -0.946960884466802 0.1782310979339 no 2816 0.171829355625086 3975 3237138
SGTC_1914 st062367 72.6 µM -0.950932438485888 0.177202339011763 no 2817 0.170819336792382 4027 978205
SGTC_1004 4084-0029 199 µM -0.9521809089135 0.176879721757663 no 2818 0.170502620678725 4061 716894 YLR208W SEC13
SGTC_2483 5729050 27.16 µM -0.954668303278046 0.176238061551403 no 2819 0.169872731935835 4029 2865180
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.954692302791958 0.1762318777054 no 2820 0.169866661758602 4070 4174840
SGTC_2079 5212404 121 µM -0.958218819081734 0.175324709062393 no 2821 0.168976214763341 3998 758462
SGTC_152 4469-0003 551.229 µM -0.958662197601713 0.175210863315249 no 2822 0.168864474040358 3951 697280
SGTC_266 formosanin C 406 nM -0.958811937321431 0.175172425427916 no 2823 0.168826747204434 3937 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2492 derrusnin 100 µM -0.958903210525274 0.175148998402394 no 2824 0.168803753630285 3990 1715307 Part of coumarin class of compounds.
SGTC_722 3534-0461 190 µM -0.959568382944584 0.174978329108838 no 2825 0.168636243958322 4094 658262
SGTC_1688 st021091 57.6 µM -0.959764230830256 0.174928098763449 no 2826 0.168586944158492 4058 3656366
SGTC_2166 5933061 31.504 µM -0.962170056366222 0.174311808214896 no 2827 0.167982093909759 4138 2877375
SGTC_2947 9072639 7.68 µM -0.963656979488088 0.173931599836047 no 2828 0.167608964805584 4079 16488146
SGTC_3239 9133757 49.47 µM -0.963681982218294 0.173925211113483 no 2829 0.167602695177352 4056 17036923
SGTC_2596 sinensetin 100 µM -0.965779397806814 0.173389808741553 no 2830 0.16707728986112 4071 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1116 jasmonic acid 1.58368 µM -0.967668800274701 0.172908404659234 no 2831 0.166604902363297 4113 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_123 0083-0120 66.675 µM -0.968473959497413 0.172703515819833 no 2832 0.166403859041358 4009 16001701
SGTC_2362 9071156 126 µM -0.969481261514829 0.172447405738429 no 2833 0.166152562564415 4093 653133
SGTC_1263 0774-1208 64.8 µM -0.97046791809059 0.172196779803125 no 2834 0.165906654401858 4104 906585
SGTC_3187 9109394 49.47 µM -0.971775364831071 0.171865026513979 no 2835 0.165581157057573 4070 17098090
SGTC_2645 abamectin 100 µM -0.971900243427709 0.171833361018843 no 2836 0.165550089343525 4010 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_748 act1.228 77.9 µM -0.97285450739793 0.171591511108383 no 2837 0.165312808860007 3994 4421505 YNR035C ARC35
SGTC_2445 5742597 35.57 µM -0.973043220129229 0.171543709276841 no 2838 0.165265910972144 4022 1774255
SGTC_3102 9121669 49.47 µM -0.97463021426663 0.171142052840588 no 2839 0.164871860299471 4086 41905072
SGTC_3171 9103192 49.47 µM -0.976664177985283 0.170628151848682 no 2840 0.164367717544548 4090 13018434
SGTC_2374 9071832 200 µM -0.977061045882105 0.170527994563258 no 2841 0.164269465637874 3967 17381698
SGTC_1959 st077091 55.8 µM -0.979000079942635 0.170039183262795 no 2842 0.163789970003324 4048 821356 YKL052C ASK1
SGTC_1413 3910-0535 34.4 µM -0.9793887532275 0.169941310729562 no 2843 0.163693966016517 4065 2876951
SGTC_2945 9067681 61.76 µM -0.979796006185414 0.169838798368368 no 2844 0.16359341196973 4131 16456930
SGTC_1098 clofazimine 15.1 µM -0.980192320722642 0.169739077466263 no 2845 0.163495597221239 4126 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_213 1246-0773 967 nM -0.980257605596833 0.169722654050106 no 2846 0.163479487847032 4058 6251622
SGTC_2989 9073649 71.4286 µM -0.981055543532405 0.169522002825051 no 2847 0.163282675912326 3964 21367202
SGTC_1920 st075728 45.7 µM -0.981524126777646 0.169404242817108 no 2848 0.163167171311094 4025 3400306
SGTC_3 0833-0587 95.581 µM -0.983782373556465 0.168837457515309 no 2849 0.162611263883043 3978 5382644
SGTC_1922 5578187 25 µM -0.98393448140231 0.168799324627247 no 2850 0.162573864188185 4099 1350412
SGTC_395 anisomycin 6.25 µM -0.984980225173055 0.16853731026386 no 2851 0.162316892226937 4078 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_8 0354-0001 70 µM -0.985021799049267 0.168526899206447 no 2852 0.162306681692613 4062 4993152
SGTC_1166 k206-0078 225 µM -0.985863005486079 0.168316330542645 no 2853 0.162100171411716 4063 5404595
SGTC_1637 st007924 17.4 µM -0.986281604177727 0.168211611061989 no 2854 0.161997472157424 4000 683336
SGTC_1509 1326-1131 80 µM -0.986972543885029 0.168038852620495 no 2855 0.161828049327857 4007 768313
SGTC_366 0181-0206 4.31 µM -0.990079612745148 0.167263391512104 no 2856 0.161067603690859 4105 274874
SGTC_383 2324-0395 7.37 µM -0.990899831784241 0.16705906698177 no 2857 0.160867247257586 4078 3146421
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.991247569198995 0.166972490815691 no 2858 0.160782353924254 4118 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2982 9019404 25.97 µM -0.995159835744987 0.166000448650117 no 2859 0.159829266319027 4024 22333232
SGTC_969 1313-0238 134 µM -0.998243675822639 0.165236819910955 no 2860 0.159080606165427 4107 5212874
SGTC_466 geldanamycin 89.2 µM -1.0047392561055 0.163635816956745 no 2861 0.157511210085353 4016 5288382 HSP90 inhibitor.
SGTC_657 3534-0529 86.7 µM -1.00588623149867 0.163354165057701 no 2862 0.157235150073967 4156 1049549
SGTC_895 0964-0006 13.7 µM -1.00602950177062 0.163319005670849 no 2863 0.157200689402643 4063 6738897
SGTC_1010 4112-3296 15.2 µM -1.00935346804533 0.162504664697522 no 2864 0.156402573028199 4181 704384
SGTC_1211 1056-0033 32.3 µM -1.00976850802053 0.162403169617541 no 2865 0.156303105661843 4156 6741922
SGTC_1194 1488-0194 225 µM -1.01196799646185 0.161865989160815 no 2866 0.155776677832904 4042 1391452
SGTC_3146 9095609 49.47 µM -1.01392548808935 0.161388886268886 no 2867 0.155309154119954 4153 17173999
SGTC_62 0180-0423 3.232 µM -1.01473881308585 0.161190923094481 no 2868 0.155115173667954 4060 30102 YGL099W LSG1
SGTC_1704 st028805 70.8 µM -1.01772455441375 0.160465553008006 no 2869 0.154404437415902 4135 2876101
SGTC_1111 tnp00062 510.699 nM -1.01881245494035 0.160201784248629 no 2870 0.154146005806902 4157 676306
SGTC_524 r073-0010 27.8 µM -1.01911461630321 0.160128573525755 no 2871 0.154074277941402 4033 2772106
SGTC_2279 7948423 32.93 µM -1.02054319417561 0.159782739393787 no 2872 0.153735457361037 4076 1247112
SGTC_1977 st070720 65.3 µM -1.02116800577226 0.159631636962713 no 2873 0.1535874238686 4138 682188
SGTC_3036 9090181 49.47 µM -1.02334760780752 0.159105261330977 no 2874 0.15307176081751 4146 25236586
SGTC_254 nsc-64875 3.808 µM -1.02490323621921 0.158730271994465 no 2875 0.15270442373849 4116 56993
SGTC_431 k089-0097 107 µM -1.02600849098299 0.158464199059397 no 2876 0.152443790879067 3932 5499420
SGTC_1223 0764-0573 147 µM -1.02605702502492 0.158452521950972 no 2877 0.152432352717122 4104 1609797
SGTC_1005 4092-0690 4.4 µM -1.02655896224554 0.158331790842255 no 2878 0.152314093085927 4150 1529343
SGTC_2513 baicalein 25.65 µM -1.02735188230785 0.158141192554849 no 2879 0.15212740015978 4127 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_929 2805-0021 398 µM -1.02966262732675 0.157586606092418 no 2880 0.151584202556735 4189 3098024
SGTC_729 4092-0585 94.1 µM -1.03048524707968 0.15738948343842 no 2881 0.151391137081987 4126 2169061
SGTC_1811 st050069 61.5 µM -1.03397062520323 0.15655608843008 no 2882 0.150574947987562 4063 3877702
SGTC_1249 0481-0015 10.2 µM -1.03430470767502 0.156476358241598 no 2883 0.150496868373866 4065 4227577
SGTC_2699 st077704 54.6 µM -1.03892283759662 0.155376961834191 no 2884 0.149420312090067 4137 645852
SGTC_2954 9074818 52.69 µM -1.03895018379094 0.155370466991049 no 2885 0.149413952624765 4160 16648742
SGTC_544 k015-0020 52.4 µM -1.04131247439927 0.154810088620883 no 2886 0.148865274531212 4137 3008304
SGTC_772 k072-0172 35.3 µM -1.04150347760291 0.154764837597227 no 2887 0.148820970025472 4170 5861980
SGTC_1421 4029-0249 71.4 µM -1.04221322223187 0.154596766881696 no 2888 0.14865641709475 4201 2894095
SGTC_3120 9124077 49.47 µM -1.04503520651783 0.153929702042587 no 2889 0.148003349061224 4255 18774327 YGL155W CDC43
SGTC_1833 st055984 71 µM -1.04841053102146 0.153134343002287 no 2890 0.147224751830763 4151 676288
SGTC_11 0438-0307 1.3 µM -1.04873473038773 0.153058092524875 no 2891 0.147150112481298 4128 4011476
SGTC_2493 resveratrol 26.09 µM -1.04962649392985 0.15284848292194 no 2892 0.146944935587876 4064 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3250 9135583 49.47 µM -1.05076211704708 0.152581829647746 no 2893 0.146683929374282 4189 7699353
SGTC_1040 k898-0338 155 µM -1.05247324457346 0.152180626626427 no 2894 0.146291239800644 4164 20969351
SGTC_474 dl-dihydrosphingosine 5 µM -1.05380529242786 0.151868790613597 no 2895 0.14598603498052 4168 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1167 k781-0610 148 µM -1.06027083833531 0.150361223634614 no 2896 0.144510701010634 4188 4525169
SGTC_841 0251-0215 91.2 µM -1.06038757911305 0.150334095232548 no 2897 0.144484155295307 4182 3888614
SGTC_1896 st058441 89 µM -1.06148551586931 0.150079114580965 no 2898 0.14423465594391 4160 688759
SGTC_2260 7964312 200 µM -1.06406945440069 0.149480168867082 no 2899 0.143648618556949 4214 231951
SGTC_1162 k048-0130 20.1 µM -1.06649559491176 0.148919254210425 no 2900 0.143099834471131 4118 6797406
SGTC_899 1083-0020 478 µM -1.06675805892736 0.148858657916187 no 2901 0.143040551087245 4222 767123
SGTC_1297 1068-0111 14.1 µM -1.06701461787447 0.148799440879706 no 2902 0.142982617535794 4133 767057
SGTC_1433 4060-0023 7.6 µM -1.06814466241911 0.148538799773455 no 2903 0.142727631020854 4176 3840627
SGTC_782 0083-0095 30.5 µM -1.0698161267013 0.148153841968491 no 2904 0.142351040939567 4145 3591729 An indicator and reagent.
SGTC_2293 7624732 200 µM -1.0726100768377 0.147511854336474 no 2905 0.141723050807514 4057 894453
SGTC_1692 fluoroquinolonic acid 71 µM -1.07320230290747 0.14737601370525 no 2906 0.141590178833999 4203 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_616 4092-0450 108 µM -1.07558986827132 0.146829221253162 no 2907 0.141055360311754 4174 787165
SGTC_844 0330-0132 15.3 µM -1.07619772960589 0.146690228451711 no 2908 0.140919417468971 4215 2828079
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.07757042201825 0.146376675240308 no 2909 0.140612753931423 4154 641818 YHR062C RPP1
SGTC_1573 oleylamine 1.06 µM -1.07778658001301 0.146327341028265 no 2910 0.140564504907941 4154 5356789 An amine of the fatty acid oleic acid.
SGTC_1214 0358-0031 63.7 µM -1.0798451914225 0.14585805915269 no 2911 0.140105561641673 4285 4301366
SGTC_1982 st072467 71.9 µM -1.08065982678765 0.145672634182318 no 2912 0.13992422969011 4138 3163533
SGTC_1570 verbenone 133 µM -1.08098019131108 0.145599757161512 no 2913 0.139852962574834 4194 29025 A natural terpanoid with antifungal properties.
SGTC_2754 granisetron 64.02 µM -1.08350425154005 0.145026437516701 no 2914 0.139292332387679 4190 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_170 4197-0004 226 µM -1.08358337060713 0.145008490864501 no 2915 0.139274783654432 4200 218692
SGTC_153 4077-0274 519.67 µM -1.08429054961317 0.144848147186083 no 2916 0.139117997057026 4187 3121976
SGTC_2200 6600604 21.907 µM -1.08492024771653 0.144705471816786 no 2917 0.138978489672179 4185 2904777
SGTC_1795 st049545 62.3 µM -1.08525976275723 0.144628584665106 no 2918 0.13890331085112 4132 5291882
SGTC_2355 9061122 103.12 µM -1.08530679370151 0.144617936128242 no 2919 0.13889289897235 4194 5302957
SGTC_2352 9027995 87.8 µM -1.08549993233609 0.144574212077107 no 2920 0.138850146822553 4138 2997347
SGTC_2531 methyl deoxycholate 70.07 µM -1.08627782630101 0.144398197275085 no 2921 0.138678047052823 4123 16667744 Haematoxylin.
SGTC_1268 0828-0275 2.46 µM -1.08641015967218 0.144368268457929 no 2922 0.138648784339895 4224 745337
SGTC_2770 toltrazuril 17.5 µM -1.08956078838024 0.143656949674161 no 2923 0.137953331884504 4115 68591 Kills coccidiodes.
SGTC_47 0149-0135 24.25 µM -1.09085140798213 0.14336624998138 no 2924 0.137669135780987 4206 5239155
SGTC_1151 3909-8316 15.3 µM -1.0914749540785 0.143225944610007 no 2925 0.137531973381696 4222 800431
SGTC_3329 9141233 27.5565 µM -1.09329102555279 0.142817835223432 no 2926 0.13713302098166 4151 4909101 YNL103W MET4
SGTC_114 0364-0001 490.298 µM -1.09410450331214 0.142635284838276 no 2927 0.136954573799519 4236 4003655
SGTC_1216 1165-0504 9.65 µM -1.09430291785346 0.142590783102627 no 2928 0.136911073010683 4212 6304004
SGTC_2565 isoliquiritigenin 100 µM -1.09498202338816 0.142438539854652 no 2929 0.136762256073139 4285 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1803 st050068 52.4 µM -1.09614993536487 0.142176972219956 no 2930 0.136506582412351 4246 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3279 9140807 49.47 µM -1.09704652871136 0.141976390281619 no 2931 0.13631052646911 4235 45595718
SGTC_3156 9099931 49.47 µM -1.09710571910174 0.141963155211126 no 2932 0.136297590229304 4220 18111053
SGTC_2619 obliquin 87.91 µM -1.09724798036901 0.141931348769784 no 2933 0.136266502032456 4155 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2504 purpurogallin 52.29 µM -1.09740978427926 0.141895178895023 no 2934 0.136231149101529 4084 5281571 An antioxidant.
SGTC_2122 5258151 111.688 µM -1.1016529195339 0.140948890086579 no 2935 0.135306296154709 4194 2173356
SGTC_1450 4112-4260 37.6 µM -1.10294399549037 0.140661810307668 no 2936 0.1350257434055 4198 1633175
SGTC_2478 5763493 32.33 µM -1.10546389897693 0.140102635925508 no 2937 0.134479314489905 4126 1365576 YLR208W SEC13
SGTC_3065 9113888 49.47 µM -1.10643525289156 0.139887493303602 no 2938 0.134269087020973 4266 16648368
SGTC_311 1315-0136 58 µM -1.10741154038904 0.139671484322757 no 2939 0.134058019331998 4220 6759207
SGTC_53 0973-0023 39.979 µM -1.10875076657571 0.139375542268439 no 2940 0.133768857409701 4076 674768
SGTC_2726 cimetidine 79.27 µM -1.10942548481728 0.139226604822755 no 2941 0.133623336698761 4189 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_306 1672-3436 11.6 µM -1.11433784417463 0.138145514699943 no 2942 0.132567138734695 4236 6797378
SGTC_1710 st031758 61.5 µM -1.11502314311301 0.137995153372668 no 2943 0.132420252214156 4242 5394341
SGTC_401 neomycin 50 µM -1.11545927423268 0.137899520060933 no 2944 0.132326830582261 4177 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1245 0418-0076 17.2 µM -1.11564135440565 0.137859607536427 no 2945 0.132287841474608 4251 6790114
SGTC_538 2922-0838 53.3 µM -1.11857833548745 0.137216901157819 no 2946 0.131660035071957 4247 777039
SGTC_1671 st016596 74.5 µM -1.1190778929039 0.137107785845795 no 2947 0.131553455076504 4277 2829167
SGTC_1672 st016598 6.51 µM -1.11964316186515 0.136984389064086 no 2948 0.131432927433336 4217 4665860 YNL267W PIK1
SGTC_2752 diclazuril 33.15 µM -1.12115671192648 0.136654358651792 no 2949 0.131110581051837 4165 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2880 9042983 58.44 µM -1.12539249668929 0.135733635030962 no 2950 0.130211374614445 4201 6464714
SGTC_814 3342-0569 96 µM -1.12877498218344 0.135001449184689 no 2951 0.129496384448022 4283 4346283
SGTC_554 4483-2211 187 µM -1.13155201995791 0.13440234937273 no 2952 0.128911410755516 4280 747107
SGTC_767 0929-0023 86 µM -1.13572213770475 0.133506148900338 no 2953 0.128036436283412 4233 1204563
SGTC_3312 9133330 71.43 µM -1.13661556547071 0.133314678072743 no 2954 0.127849515084056 4260 17617324
SGTC_1442 4112-3290 3 µM -1.13710292257434 0.133210312070749 no 2955 0.127747631164053 4219 704353
SGTC_1927 st060202 13.8 µM -1.1374407426522 0.133138001957112 no 2956 0.127677041671885 4127 688887
SGTC_1754 st042065 16.137 µM -1.14091370554824 0.132396183383009 no 2957 0.126952917698557 4015 1126236 YIL048W NEO1
SGTC_1335 1486-0900 202 µM -1.1410348485644 0.132370358969394 no 2958 0.126927710688922 4218 X1335
SGTC_3020 9089140 49.47 µM -1.14325319067468 0.131898082222688 no 2959 0.126466741849552 4248 17217859
SGTC_3149 9097855 49.47 µM -1.14366379439098 0.131810793863048 no 2960 0.12638154696749 4244 25236625 YMR079W SEC14
SGTC_713 1488-1073 324 µM -1.1438258653589 0.131776350912071 no 2961 0.1263479303786 4221 3312542
SGTC_3234 9132280 49.47 µM -1.14382754749513 0.131775993460895 no 2962 0.126347581504356 4262 17612295
SGTC_1774 st048371 48.465 µM -1.14477196630616 0.131575411636188 no 2963 0.126151815471752 4213 4242727
SGTC_2600 tangeritin 87.95 µM -1.14537164325013 0.131448157775755 no 2964 0.126027619860105 4172 68077 A bioactive flavone.
SGTC_686 1319-0111 510 µM -1.14609836980724 0.131294057383805 no 2965 0.125877226027684 4281 4562600
SGTC_1825 st052143 62.6 µM -1.14648263103315 0.131212626276132 no 2966 0.125797754953384 4286 674173
SGTC_2346 9031566 143.75 µM -1.15489260908774 0.12943914948469 no 2967 0.124067203205783 4220 4771086
SGTC_3166 9102297 49.47 µM -1.15525378417178 0.129363359478107 no 2968 0.123993257785162 4243 25237072
SGTC_2952 9073731 13.78 µM -1.15645228400703 0.12911208323279 no 2969 0.123748103123097 4290 16457353
SGTC_2448 5185112 27.17 µM -1.15849727849455 0.128684113512274 no 2970 0.12333058081966 4266 5718189
SGTC_1905 st060207 84.5 µM -1.16219917452577 0.127911898744743 no 2971 0.12257728495178 4236 1948547
SGTC_1386 3228-0095 33.8 µM -1.16225075321056 0.127901162234002 no 2972 0.122566812098209 4270 870181
SGTC_2458 5808907 16.39 µM -1.16280929258198 0.127784937956007 no 2973 0.122453443033594 4396 2731747
SGTC_1850 st056238 17 µM -1.16289659869114 0.127766777404045 no 2974 0.122435728800967 4263 5393177
SGTC_1284 0929-0043 16 µM -1.16447227486665 0.127439329157109 no 2975 0.122116336367348 4260 1239883
SGTC_2551 apiole 73.87 µM -1.16464873456683 0.127402694656993 no 2976 0.122080604125815 4154 10659 A possible DNA adduct former.
SGTC_470 aa-861 153 µM -1.16552007466667 0.12722190459098 no 2977 0.121904269580865 4218 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1860 st056228 74.6 µM -1.16834694489941 0.126636600362021 no 2978 0.121333423203003 4240 688679
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.17003261268534 0.126288476315815 no 2979 0.120993922432258 4319 165506
SGTC_1842 st055362 61.2 µM -1.17121470120786 0.126044749616156 no 2980 0.120756243746289 4227 676032
SGTC_232 clozapine 119 µM -1.17438606442935 0.125392488842188 no 2981 0.120120212260593 4238 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1911 st060208 74.3 µM -1.17591210686335 0.125079465649457 no 2982 0.119815000193844 4303 688783
SGTC_492 tmb-8 126 µM -1.17678054292193 0.124901575125804 no 2983 0.119641555271078 4235 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2807 7945238 51.95 µM -1.17906373589594 0.124434729151236 no 2984 0.119186398715861 4279 17148797
SGTC_425 3825-7017 13.1 µM -1.18282726416896 0.123667863870751 no 2985 0.118438806450517 4316 3397440
SGTC_1826 st055655 41.6 µM -1.18645159281879 0.122932495945959 no 2986 0.11772200366343 4295 676168
SGTC_2793 7325131 81.82 µM -1.18667438288966 0.122887392590124 no 2987 0.117678041666815 4226 4176441
SGTC_1482 3346-2049 8.48 µM -1.18802603859664 0.122614001638715 no 2988 0.11741157562675 4285 3826804
SGTC_1781 st038725 66.3 µM -1.18891070250284 0.122435297392484 no 2989 0.117237404073411 4271 4270275 YIL048W NEO1
SGTC_2601 securinine 100 µM -1.18938307011952 0.122339952881056 no 2990 0.117144479897914 4259 442872 A GABA receptor antagonist.
SGTC_907 3448-6986 75.5 µM -1.19440816115498 0.121328894314151 no 2991 0.116159172985025 4311 590582
SGTC_99 0109-0120 622.8 µM -1.19684346622399 0.120841025427761 no 2992 0.115683786397052 4250 759414
SGTC_3004 9076122 71.4286 µM -1.19694756207584 0.120820202538323 no 2993 0.115663497086812 4295 44782551
SGTC_1555 citronellol 128 µM -1.19772071842965 0.120665622678148 no 2994 0.1155128803787 4244 8842 A terpine precursor.
SGTC_593 1203-0218 61.7 µM -1.20096191053985 0.120019115254934 no 2995 0.114882988400978 4314 3666956
SGTC_211 3455-0679 143.504 µM -1.20133063839861 0.119945721570809 no 2996 0.114811485062203 4307 748649
SGTC_1380 2291-0730 164 µM -1.20336482397337 0.11954139445026 no 2997 0.114417586933572 4294 2999191
SGTC_2457 5731572 11.68 µM -1.20453896959073 0.119308452236398 no 2998 0.114190664686327 4336 2865357
SGTC_1236 0330-0013 258 µM -1.20470110114285 0.119276311667732 no 2999 0.114159355397901 4300 4617066
SGTC_3346 9158254 43.5805 µM -1.20614313837704 0.118990714540133 no 3000 0.113881152025573 4291 17639500
SGTC_1779 st039427 55 µM -1.20632712722625 0.118954310102259 no 3001 0.113845690971593 4271 1124498
SGTC_3185 9108267 49.47 µM -1.20704308823541 0.118812723338142 no 3002 0.113707775260286 4293 4910486
SGTC_1205 4161-2785 76 µM -1.20735959282039 0.118750170094384 no 3003 0.113646844895061 4331 3498106
SGTC_849 0386-0493 241 µM -1.20989452573748 0.118250011017786 no 3004 0.113159684043638 4288 726119
SGTC_1183 1254-0324 198 µM -1.21056114454378 0.118118730416108 no 3005 0.113031821712558 4366 5799357
SGTC_1480 1070-0044 41.2 µM -1.21085667053447 0.118060563982262 no 3006 0.112975170679277 4321 3124987
SGTC_418 lividomycin a 100 µM -1.2114897163696 0.117936033928862 no 3007 0.112853886782571 4302 72394 An antibiotic.
SGTC_2757 clomiphene 4.22 µM -1.21275997002918 0.117686435472667 no 3008 0.112610802051025 4316 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_282 k297-0036 65.7 µM -1.21300196066932 0.117638927957823 no 3009 0.112564535447338 4299 5061378
SGTC_898 1000-0849 28.3 µM -1.21492207035449 0.117262453862493 no 3010 0.112197907618522 4306 6751807
SGTC_2444 5485484 36.41 µM -1.2155217788116 0.117145044673733 no 3011 0.11208357373813 4368 6790631
SGTC_3189 9110682 49.47 µM -1.21764349508614 0.116730329821593 no 3012 0.111679739091286 4343 17122418
SGTC_1604 st002052 72.4 µM -1.21818985567555 0.116623705840606 no 3013 0.111575916858484 4375 6254834 YHR062C RPP1
SGTC_3115 9123671 49.47 µM -1.21847768094037 0.116567563621264 no 3014 0.111521250611631 4427 3286988
SGTC_3326 9140064 16.379 µM -1.22347862417403 0.115595155008739 no 3015 0.110574486498051 4239 1868434
SGTC_1742 st038235 28.8875 µM -1.22515320809117 0.115270832049534 no 3016 0.110258750378641 4340 564103 YBR002C RER2
SGTC_3233 9132340 49.47 µM -1.22718577702713 0.11487804646754 no 3017 0.109876386965791 4313 17682950
SGTC_145 3737-0113 38.366 µM -1.23535299722495 0.113309365586381 no 3018 0.108349578853633 4279 6849351
SGTC_3034 9090421 49.47 µM -1.23679066754818 0.113034820889696 no 3019 0.108082403826431 4215 17173761
SGTC_2887 9044784 58.44 µM -1.24002274545977 0.112419341308197 no 3020 0.107483490650422 4279 6465546
SGTC_3207 9114163 49.47 µM -1.2423742860909 0.111973048323666 no 3021 0.10704924921006 4330 849233
SGTC_903 1134-0042 114 µM -1.24268039814464 0.11191504540425 no 3022 0.106992814996693 4327 701009
SGTC_382 3229-0966 23.2 µM -1.24314344763403 0.111827346402517 no 3023 0.106907488896868 4365 5722370
SGTC_951 1171-0579 82.7 µM -1.24394194694556 0.111676230545044 no 3024 0.106760464819238 4283 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2889 9059656 51.95 µM -1.24593585804176 0.111299521209519 no 3025 0.106393972162008 4388 3949838
SGTC_1375 2910-0797 186 µM -1.24933200357617 0.110659983759667 no 3026 0.105771833546269 4320 742508
SGTC_3225 9130819 49.47 µM -1.25045114389427 0.110449813443329 no 3027 0.105567395879813 4279 4547121
SGTC_2078 5212016 200 µM -1.25279992928628 0.110009651355388 no 3028 0.105139263702173 4219 1899708
SGTC_133 0724-0033 378.92 µM -1.25532024729566 0.109538745437219 no 3029 0.104681263954775 4161 280309
SGTC_2913 7966556 36.57 µM -1.25688392125857 0.109247311183242 no 3030 0.104397835780269 4233 2976516
SGTC_3270 9137563 49.47 µM -1.26049447831355 0.10857651239827 no 3031 0.10374551927503 4324 17015724
SGTC_1100 amiodarone 5.07 µM -1.26136440134714 0.10841533484425 no 3032 0.10358879395802 4385 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2302 7771753 200 µM -1.26239271879868 0.108225032412045 no 3033 0.103403753971319 4335 2203047
SGTC_828 2074-0507 139 µM -1.26503435197615 0.107737269058899 no 3034 0.102929506952211 4410 X828
SGTC_1354 1498-1681 81 µM -1.26571545478349 0.107611764282935 no 3035 0.102807486592293 4320 5754243
SGTC_1923 st058458 19.1 µM -1.26595032184612 0.107568510468344 no 3036 0.102765434267104 4342 3534982
SGTC_2189 6047310 154.431 µM -1.26971582587111 0.106876753941849 no 3037 0.102092936711612 4308 711535
SGTC_704 1310-0270 142 µM -1.27004814406925 0.106815858617816 no 3038 0.102033740693395 4347 5718033
SGTC_637 1181-0519 7.26 µM -1.27073757127508 0.106689605055497 no 3039 0.101911012317311 4341 6252091 YGR060W ERG25
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.27187298936257 0.106481912791547 no 3040 0.101709125109734 4357 688798
SGTC_1844 rapamycin 4 nM -1.2721555484801 0.106430272073791 no 3041 0.101658928920458 4207 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_309 k408-0051 1.48 µM -1.27471024299635 0.105964194856748 no 3042 0.101205909997003 4251 3640463
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.27858513298841 0.105260079872502 no 3043 0.10052159402835 4375 6728940
SGTC_2787 5284540 71.43 µM -1.28179597400033 0.104679200432526 no 3044 0.0999571134409941 4376 736958
SGTC_624 k048-0052 28 µM -1.28225740451729 0.104595913321032 no 3045 0.0998761824571644 4325 6835531
SGTC_3228 9131799 49.47 µM -1.28379703235107 0.104318361466746 no 3046 0.0996064911201471 4381 17015818
SGTC_777 1315-0167 517 µM -1.28455547315027 0.104181832195579 no 3047 0.0994738334496233 4374 4221767
SGTC_1660 st012960 28.1 µM -1.28852032884819 0.103470214479268 no 3048 0.0987824485063965 4384 24207266
SGTC_2349 9023730 187.07 µM -1.29010088069751 0.103187520606198 no 3049 0.0985078170735038 4403 4126287
SGTC_2629 bisabolol 100 µM -1.29234317750279 0.102787431423718 no 3050 0.0981191627106056 4388 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3113 9123498 49.47 µM -1.29557274699841 0.102213167700426 no 3051 0.0975613617038515 4467 8897275
SGTC_3110 9122132 49.47 µM -1.29903040823266 0.101600936711966 no 3052 0.0969667468978558 4416 918317
SGTC_651 3253-0966 34.4 µM -1.30062898109988 0.101318789740775 no 3053 0.0966927410428312 4381 781462
SGTC_2721 ifenprodil 61.44 µM -1.30178252564477 0.101115544829517 no 3054 0.0964953694928432 4365 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2871 9038510 12.99 µM -1.30261936024928 0.100968287644029 no 3055 0.0963523724021824 4349 4945164
SGTC_2002 4023503 131 µM -1.3048195178564 0.100581873463869 no 3056 0.0959771557131832 4357 4736863 YCR052W RSC6
SGTC_571 k831-0106 44.2 µM -1.30731927425448 0.100144151131109 no 3057 0.0955521504374872 4265 4783639
SGTC_1602 st001878 87.6 µM -1.31050628548589 0.0995881052627101 no 3058 0.0950123096411234 4353 595405 YLR310C CDC25
SGTC_2191 5911152 200 µM -1.31486784519972 0.0988307943489365 no 3059 0.0942771605092593 4394 2875902
SGTC_2848 9016370 25.97 µM -1.31494093312883 0.098818139867588 no 3060 0.0942648772424357 4370 7894410
SGTC_2280 7785178 200 µM -1.32046425429974 0.0978652565533343 no 3061 0.0933400314989765 4375 2954328
SGTC_1002 4049-0206 172 µM -1.32121236282703 0.0977367125208082 no 3062 0.0932152826356627 4338 4662749
SGTC_3082 9117008 49.47 µM -1.32504624060775 0.0970798972740385 no 3063 0.0925779074967255 4416 41448529
SGTC_1770 st043884 66.3 µM -1.32654055335319 0.0968247728255715 no 3064 0.0923303558708544 4401 670149
SGTC_1696 st025591 34.7925 µM -1.32833732295859 0.096518662125419 no 3065 0.0920333475454952 4382 2787147
SGTC_2938 9059746 27.26 µM -1.32919528019919 0.0963727453700532 no 3066 0.0918917759151828 4389 6471769
SGTC_2643 anethole 100 µM -1.33110614280865 0.0960483388610932 no 3067 0.0915770440126818 4375 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_710 3448-4187 58 µM -1.33226224736075 0.0958524576301286 no 3068 0.0913870140799823 4359 3946412
SGTC_687 k029-0044 34.9 µM -1.33393975196083 0.0955687572190477 no 3069 0.0911118011658427 4464 5829338
SGTC_1554 st069299 38.7 µM -1.33993079761421 0.0945605928790561 no 3070 0.0901339221836792 4354 24207999
SGTC_760 0568-0725 82.9 µM -1.34263190703166 0.0941086271355037 no 3071 0.0896955967036039 4409 3916171
SGTC_3112 9123419 49.47 µM -1.34591086214324 0.093562116943782 no 3072 0.0891656326728615 4456 17015854
SGTC_3331 9141060 1.957 µM -1.34738808593731 0.0933166722308795 no 3073 0.0889276378482298 4355 4906567 YPR165W RHO1
SGTC_2306 7482397 179.52 µM -1.34914964032993 0.0930246074694698 no 3074 0.08864445324739 4419 891448
SGTC_3066 9117245 49.47 µM -1.35364248739498 0.0922827561544059 no 3075 0.087925232470931 4443 17176980
SGTC_832 4083-0019 164 µM -1.35616703290705 0.0918678336288094 no 3076 0.0875230143364708 4493 1990758
SGTC_1745 st081495 74 µM -1.36041728428369 0.0911724061403863 no 3077 0.086848955961878 4263 13842402 YBL026W LSM2
SGTC_889 0919-1524 82.7 µM -1.3622057426806 0.0908809477963716 no 3078 0.0865664820047669 4425 3905452
SGTC_3343 9148379 18.9835 µM -1.36803990349845 0.0899349823352913 no 3079 0.0856497930223715 4416 1955036
SGTC_669 0108-0021 26.2 µM -1.37223945372295 0.0892585997019117 no 3080 0.0849944535032524 4432 17201
SGTC_1261 0712-0010 12.7 µM -1.3744407202103 0.0889055775203828 no 3081 0.0846524509173223 4399 2840123
SGTC_2252 omeprazole 400 µM -1.3754328327624 0.0887468103882188 no 3082 0.0844986479278515 4449 4594 A proton pump inhibitor.
SGTC_1448 4255-0083 152 µM -1.37561901374629 0.0887170395090734 no 3083 0.0844698084583527 4438 5399660
SGTC_2381 9035592 200 µM -1.37563477426506 0.0887145196979159 no 3084 0.0844673674900854 4425 4749657
SGTC_3108 9121785 49.47 µM -1.37697249478931 0.0885008374990292 no 3085 0.0842603759280355 4285 17140271
SGTC_2768 sulfasalazine 50.2 µM -1.37839809068469 0.0882735407435817 no 3086 0.0840402062886316 4401 5384001 An antioxidant and salicylic acid derivative.
SGTC_1560 lithocholic acid 53.1 µM -1.37880064524291 0.0882094363592282 no 3087 0.0839781138636673 4359 9903 A bile acid which acts as a detergent.
SGTC_1006 4099-6547 255 µM -1.37931957490575 0.0881268511468938 no 3088 0.0838981218794072 4421 3146833
SGTC_2092 5303694 80.6725 µM -1.38129979344543 0.0878122383133952 no 3089 0.083593400852014 4428 1963699
SGTC_1990 st072050 59.8 µM -1.38339398371219 0.0874804301936448 no 3090 0.0832720471399585 4406 17233948
SGTC_804 1595-0054 20.9 µM -1.38371695059774 0.0874293420011561 no 3091 0.0832225706106434 4394 761523 Stimulates phospholipase C.
SGTC_1721 st082152 9.2685 µM -1.38802695456226 0.0867496984510076 no 3092 0.0825644187158477 4361 5296051
SGTC_2611 pyromycin 23.93 µM -1.39018009681982 0.0864116523498192 no 3093 0.0822370978558274 4387 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1158 4092-0494 91.8 µM -1.39064765658023 0.0863383752079235 no 3094 0.0821661487166063 4504 1148199
SGTC_942 3253-1115 227 µM -1.39216438371493 0.0861009897785946 no 3095 0.0819363126521444 4455 46497897
SGTC_207 4185-0010 4.486 µM -1.39261879304565 0.0860299645823453 no 3096 0.0818675484901113 4505 3761753
SGTC_1497 4476-2978 41.3 µM -1.39468908575861 0.0857069279515853 no 3097 0.0815548087738479 4471 1528379
SGTC_2720 fluspirilene 36.88 µM -1.40419806504768 0.0842348577847946 no 3098 0.080129938949976 4416 3396 An atypical antipsychotic.
SGTC_147 4466-0538 29.23 µM -1.40449251808196 0.0841895787966086 no 3099 0.0800861190463184 4493 6742687 YHR072W ERG7
SGTC_198 3454-2873 16.191 µM -1.40533460022941 0.0840601899539695 no 3100 0.0799609020737659 4447 710957
SGTC_2597 laccaic acid a 100 µM -1.4056539389758 0.0840111615109859 no 3101 0.079913455380194 4419 5491415 A textile dye.
SGTC_2193 5925765 200 µM -1.40622079517905 0.0839241843185715 no 3102 0.0798292854948038 4437 877370
SGTC_1859 st055998 20 µM -1.40838381688925 0.0835929162029096 no 3103 0.079508724288115 4379 676301
SGTC_1758 st042942 75.2445 µM -1.41066047256164 0.0832453072818116 no 3104 0.0791723756698497 4410 669317
SGTC_874 0599-0792 117 µM -1.41453286266601 0.0826565532577746 no 3105 0.0786027527433359 4445 765305
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.41464269461212 0.0826399003481947 no 3106 0.0785866420439328 4448 5377381
SGTC_1234 0326-0494 15.5 µM -1.41491247601277 0.0825990063448672 no 3107 0.0785470797826589 4504 1547813
SGTC_1109 tnp00067 928.257 nM -1.41663663405263 0.082338014687105 no 3108 0.0782945960268185 4448 676295
SGTC_1287 0971-0001 34.6 µM -1.41737443884344 0.0822265205870158 no 3109 0.0781867409523372 4422 4665869
SGTC_1303 1160-0052 261 µM -1.41893451685656 0.0819911423340425 no 3110 0.0779590540123463 4393 3562476
SGTC_1466 k213-0079 57.5 µM -1.42096513004878 0.0816855325563366 no 3111 0.0776634484569888 4412 3657981
SGTC_1872 amphotericin b 148 nM -1.42304806158451 0.0813729418457172 no 3112 0.0773611115913356 4453 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_358 0075-0058 9.45 µM -1.42712526376671 0.0807636789416022 no 3113 0.076771895806054 4414 1069125
SGTC_542 3381-0244 89.3 µM -1.4274212437735 0.0807195846352308 no 3114 0.0767292555447679 4476 1112843
SGTC_2744 captopril 92.04 µM -1.4285856835074 0.0805462859702645 no 3115 0.0765616757013802 4517 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_870 0573-2213 57.6 µM -1.43454546151311 0.0796637150380749 no 3116 0.075708332734862 4438 3916321
SGTC_1434 4073-0095 163 µM -1.43539691833779 0.0795382241883077 no 3117 0.0755870118308047 4455 24133745
SGTC_335 4077-0256 27.6 µM -1.44242545186772 0.0785080407471088 no 3118 0.07459119400783 4398 3121989
SGTC_2853 9015042 58.44 µM -1.45646347462493 0.0764807860734589 no 3119 0.0726322698185113 4399 6457456
SGTC_2270 7924575 90.91 µM -1.45646516013801 0.0764805450797658 no 3120 0.0726320370038693 4438 1262135
SGTC_2949 9072542 2.23 µM -1.45668038929641 0.0764497764846722 no 3121 0.0726023127702923 4451 16457352
SGTC_18 0111-0177 500 nM -1.4602957155758 0.0759343455801821 no 3122 0.0721044095264198 4554 721752
SGTC_2164 5685496 200 µM -1.46201840690987 0.0756896771861463 no 3123 0.0718680829364154 4390 759046
SGTC_48 0382-0018 55 µM -1.46477542351264 0.0752993571639621 no 3124 0.0714910995963523 4492 762596
SGTC_1481 3346-2004 36 µM -1.47123566523543 0.0743907711364058 no 3125 0.0706136975240028 4555 2770522
SGTC_2214 7179297 48.276 µM -1.47322949106483 0.0741120511380854 no 3126 0.0703445827716115 4546 769744
SGTC_1522 st012842 45.6 µM -1.47711322046852 0.0735714298092504 no 3127 0.0698226451410732 4326 3491067 YOR116C RPO31
SGTC_3037 9091026 49.47 µM -1.480599127259 0.0730887585510801 no 3128 0.0693567140435559 4359 25236398 YIL048W NEO1
SGTC_430 0958-0115 16.4 µM -1.48826129456231 0.0720363482714813 no 3129 0.0683409990752057 4421 6833180
SGTC_1686 st019653 115.5 µM -1.49186589207128 0.0715452874545752 no 3130 0.0678671528892358 4490 97252
SGTC_1646 st011709 75.6 µM -1.49329826399208 0.0713508675239388 no 3131 0.0676795649064361 4458 5757843
SGTC_2505 galangin 7.89 µM -1.49380150481846 0.0712826575606469 no 3132 0.067613754058514 4395 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3109 9122853 49.47 µM -1.49781353157368 0.0707406509685745 no 3133 0.0670908520674938 4508 1234709
SGTC_1941 st076221 61.8 µM -1.49981095065041 0.0704719921844857 no 3134 0.0668316899579471 4373 2828568
SGTC_1207 2099-0101 141 µM -1.4999130979146 0.0704582741858891 no 3135 0.06681845735162 4491 5837381
SGTC_1067 clotrimazole 1.36 µM -1.50003711306236 0.0704416221709425 no 3136 0.0668023946080484 4524 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1496 4469-0713 57.4 µM -1.50363579737532 0.0699597289209408 no 3137 0.0663375843085946 4484 746691
SGTC_2113 5491891 107.031 µM -1.50853887474598 0.0693072541989211 no 3138 0.0657083324881253 4498 789979
SGTC_939 1165-0479 45.3 µM -1.50961762010056 0.0691643317958476 no 3139 0.0655705113303674 4467 1377347
SGTC_1396 3511-0007 98.6 µM -1.51007715534078 0.0691035172339339 no 3140 0.0655118689562931 4528 X1396
SGTC_5 0352-0601 109.883 µM -1.51167359507881 0.0688925657537286 no 3141 0.065308459562082 4411 762456
SGTC_2935 9038016 29.96 µM -1.51455614046163 0.0685129278019541 no 3142 0.0649424232257813 4460 6463195
SGTC_1341 1486-1360 280 µM -1.51643826884408 0.0682659193020566 no 3143 0.0647042842813818 4494 3976547
SGTC_1053 3366-3204 134 µM -1.51871895225173 0.0679675265014387 no 3144 0.0644166270084825 4512 3632071 YPR165W RHO1
SGTC_424 splitomicin 100 mM -1.51895601143452 0.0679365687763623 no 3145 0.0643867843862439 4496 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1165 k072-0275 30.3 µM -1.52204944009631 0.0675335931600446 no 3146 0.0639983465783366 4482 6153523 YGL055W OLE1
SGTC_2159 5658611 73.75 µM -1.52809300335701 0.0667516407879648 no 3147 0.0632447241912536 4497 793844
SGTC_1852 st056254 31.4 µM -1.52907062339841 0.0666258114282334 no 3148 0.0631234685046252 4476 442583
SGTC_2436 5633522 8.09 µM -1.52945167215738 0.0665768164392353 no 3149 0.0630762555182845 4499 5724242
SGTC_2198 6589944 200 µM -1.53016716960129 0.0664848936195641 no 3150 0.0629876777335255 4530 5290268
SGTC_35 0133-0054 64.071 µM -1.5350667475506 0.0658580631093169 no 3151 0.0623837166329903 4480 99677
SGTC_1724 st037281 8.293 µM -1.5354463717879 0.0658096874884293 no 3152 0.0623371102718378 4462 574124 YDL195W SEC31
SGTC_1630 st005209 31.3 µM -1.53900260570921 0.0653578521252564 no 3153 0.0619018300563345 4506 3367314
SGTC_444 curcumin 90.4 µM -1.53979541870179 0.0652574504994615 no 3154 0.0618051145045709 4434 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2285 7945142 200 µM -1.54084007367666 0.0651253384383366 no 3155 0.0616778568137995 4519 2970608
SGTC_143 4032-1194 15.74 µM -1.55149617685088 0.0637895465055721 no 3156 0.0603914114196578 4548 1806963
SGTC_496 calpeptin 138 µM -1.55287635435925 0.0636181051181525 no 3157 0.0602263384071264 4508 73364 A calpain inhibitor.
SGTC_3202 9113761 49.47 µM -1.55391295340266 0.0634895779049649 no 3158 0.0601025907414992 4442 4798415
SGTC_961 1252-1571 372 µM -1.56175507311482 0.0625237762630407 no 3159 0.0591728496372916 4548 6813498
SGTC_277 nystatin 15.5 µM -1.56251433773393 0.0624308799707372 no 3160 0.0590834354431384 4547 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1235 benzylparaben 21.5 µM -1.56277782989584 0.0623986667789831 no 3161 0.059052430281323 4565 7180
SGTC_1765 st044815 90.4 µM -1.56393450160387 0.0622574113707891 no 3162 0.0589164755136752 4544 645695
SGTC_2326 6164455 177.58 µM -1.56692887439777 0.0618928902126491 no 3163 0.0585656588031939 4463 2888790
SGTC_1681 tripelennamine 100 µM -1.56713091502833 0.0618683548324596 no 3164 0.058542047183699 4429 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2683 piperine 63.03 µM -1.56799096893634 0.0617639966626309 no 3165 0.0584416199995254 4559 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2142 5622915 118.518 µM -1.56828865822907 0.0617279073418106 no 3166 0.0584068908098124 4541 5322196
SGTC_3006 9075424 71.4286 µM -1.57363529235961 0.061082526151167 no 3167 0.0577858946122961 4493 7465181
SGTC_850 0388-0143 75.9 µM -1.57950150171801 0.0603805086848181 no 3168 0.0571105361665594 4538 67273
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.58389267201858 0.059859155579374 no 3169 0.0566090726330742 4540 6708561
SGTC_410 α-linolenic acid 100 µM -1.58972475127067 0.0591721862189969 no 3170 0.055948430997969 4571 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3285 9112818 20.8695 µM -1.59085748756112 0.0590394794126947 no 3171 0.0558208259275594 4527 17017947 YPR165W RHO1
SGTC_78 0336-0123 156.75 µM -1.59103246694295 0.0590190003701105 no 3172 0.0558011346326104 4402 6765896
SGTC_1347 1493-0251 600 nM -1.59115707797865 0.0590044196797558 no 3173 0.0557871148783767 4581 3986378
SGTC_2219 9098279 200 µM -1.59284586376627 0.058807094038188 no 3174 0.0555973867036728 4486 902349
SGTC_2056 5235370 200 µM -1.60790592588614 0.0570702295196014 no 3175 0.0539278919047047 4478 5511916
SGTC_2067 5224629 34.075 µM -1.61488039104748 0.0562796735367455 no 3176 0.0531682997341642 4519 2835000
SGTC_757 1066-0008 322 µM -1.61606161748689 0.0561466404582876 no 3177 0.0530404958657578 4563 6842497
SGTC_1065 prochlorperazine maleate 2.48 µM -1.62045859536001 0.0556536186127251 no 3178 0.0525669008204811 4585 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1760 st045453 10.4495 µM -1.62462540361633 0.0551895643695198 no 3179 0.0521212004133546 4561 3323419 YIL048W NEO1
SGTC_2060 5238662 140 µM -1.6294576599132 0.0546552332143587 no 3180 0.0516080855238605 4525 790130
SGTC_2031 5180455 200 µM -1.63145253450331 0.0544358445000943 no 3181 0.0513974337740691 4557 29949
SGTC_1816 st051957 91.6 µM -1.63878719649392 0.0536351897677735 no 3182 0.0506287932980089 4574 674121
SGTC_1356 1502-0781 85.8 µM -1.64253108002749 0.0532301171912707 no 3183 0.0502399952778159 4574 567702
SGTC_3005 9076496 71.4286 µM -1.65052225812393 0.0523736189316663 no 3184 0.0494180823536445 4535 21368410
SGTC_1464 k208-0027 110 µM -1.65264795872624 0.0521476375147169 no 3185 0.0492012657548961 4554 X1464
SGTC_2182 6325192 200 µM -1.65390490941724 0.0520143769662364 no 3186 0.0490734174967472 4591 736248
SGTC_2322 7413319 38.22 µM -1.65686658297617 0.0517014532748465 no 3187 0.0487732259087264 4514 1840400
SGTC_2482 5981709 142.65 µM -1.66096776177384 0.051270605136146 no 3188 0.0483599607882398 4509 877755
SGTC_2171 5739187 198.077 µM -1.66662718411227 0.0506807522303924 no 3189 0.0477942800135865 4544 2262761
SGTC_908 3448-7491 47.7 µM -1.67464261293421 0.0498546067948945 no 3190 0.0470021865889774 4580 1203031
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.67598541644857 0.0497172612528174 no 3191 0.0468705245984119 4554 5379071
SGTC_812 4251-0442 148 µM -1.68193806499092 0.0491120399936934 no 3192 0.0462904252254671 4602 5723007
SGTC_1057 3448-5381 134 µM -1.68286113059196 0.0490187187470848 no 3193 0.0462009888365578 4567 5497911
SGTC_1209 2323-2347 50.3 µM -1.68790362391001 0.0485114244175774 no 3194 0.0457148654455459 4593 5412760
SGTC_296 1222-0039 74.9 µM -1.69524212934803 0.0477806523406243 no 3195 0.0450147489613294 4597 5984176
SGTC_1883 5-benzylidenerhodanine 20 µM -1.71069395714853 0.046270774365621 no 3196 0.0435688119074124 4575 1273210
SGTC_42 0133-0086 60.653 µM -1.71235362966991 0.0461109034215432 no 3197 0.043415759495211 4490 162923 Model of phenazepam hydroxylation.
SGTC_1368 1852-0141 284 µM -1.71276113852737 0.046071717316461 no 3198 0.0433782461121181 4562 2838987
SGTC_837 0091-0265 12.5 µM -1.71352413721736 0.0459984191961313 no 3199 0.0433080783498053 4607 759367
SGTC_60 0986-0278 202 µM -1.72104283191007 0.045281128885311 no 3200 0.0426215259176787 4551 3110598
SGTC_87 0100-0052 35.5 µM -1.72428346108345 0.0449747576998939 no 3201 0.0423283417562579 4615 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_453 enantio-paf c16 10 µM -1.72522016993229 0.0448865121617025 no 3202 0.0422439010460763 4197 13871343 A lipid and platelet activating factor
SGTC_129 0088-0017 176.636 µM -1.72719390837713 0.0447010263674548 no 3203 0.0420664222526239 4465 182446
SGTC_374 0880-0231 82.3 µM -1.72953179355581 0.0444821183557756 no 3204 0.0418569806661483 4461 6833587
SGTC_2557 derrustone 83.84 µM -1.73159395974158 0.0442897449863456 no 3205 0.0416729412153709 4576 629853 An antioxidant.
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.73300537945935 0.0441584647713159 no 3206 0.0415473563272786 4630 65057 A dermal irritant. YDR527W RBA50
SGTC_2049 5262831 67.185 µM -1.73868909446457 0.043632978071319 no 3207 0.0410447326620268 4566 763417
SGTC_27 0485-0001 32.618 µM -1.74272764964745 0.0432626699258459 no 3208 0.0406905997476153 4616 2054479
SGTC_1499 4480-0877 67.3 µM -1.74406117119312 0.0431409538785134 no 3209 0.040574211905171 4618 2861909
SGTC_1274 0865-0114 173 µM -1.74507012737899 0.0430490461902097 no 3210 0.0404863313559444 4611 870624
SGTC_833 3852-0053 558 µM -1.7455095533035 0.0430090675477981 no 3211 0.0404481054929648 4644 3123681
SGTC_3018 9082602 49.47 µM -1.74602589122246 0.0429621298465194 no 3212 0.0404032264717369 4493 17332089
SGTC_333 3486-0131 40.1 µM -1.74842710768157 0.0427443907948393 no 3213 0.0401950486793542 4619 6744690
SGTC_288 1315-0019 35.1 µM -1.75244202360599 0.0423823170797118 no 3214 0.0398489153815689 4642 6811474
SGTC_2712 st079126 47.7 µM -1.75384431516191 0.0422564415317534 no 3215 0.0397285936617713 4613 3152970
SGTC_2620 irigenin 100 µM -1.75416231118458 0.0422279389957923 no 3216 0.0397013495738756 4579 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1322 1348-1070 12 µM -1.75852448043527 0.04183851830185 no 3217 0.0393291549853801 4620 6758089
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.7623672172248 0.0414978824028397 no 3218 0.0390036368868435 4698 4620898
SGTC_2314 7727897 200 µM -1.76659761450225 0.0411254849997268 no 3219 0.0386478203929328 4587 900724
SGTC_1130 3454-2858 15.9 µM -1.76687636198274 0.0411010426189233 no 3220 0.0386244682684333 4572 715628 YIL048W NEO1
SGTC_2833 9001315 45.46 µM -1.77112782971703 0.040729704360898 no 3221 0.0382697235547309 4550 2989378
SGTC_1716 st033144 30.6155 µM -1.77133205728746 0.0407119351568731 no 3222 0.0382527497946395 4578 674617
SGTC_3210 9128157 49.47 µM -1.7722965449301 0.0406281030857228 no 3223 0.0381726722389665 4557 17590849
SGTC_1800 st050079 29.0735 µM -1.77252671646436 0.0406081175828693 no 3224 0.0381535822356917 4443 3645560
SGTC_2931 9014674 55.67 µM -1.77782630205844 0.0401501641215592 no 3225 0.0377161936240466 4570 2996810
SGTC_2181 6316240 54.2555 µM -1.78093375216118 0.0398835969580135 no 3226 0.0374616369588793 4639 12779990
SGTC_3169 9102970 49.47 µM -1.78724251260233 0.0393468358055079 no 3227 0.0369491504699781 4673 17027839
SGTC_820 1582-0060 59.9 µM -1.78839757986669 0.0392492000168936 no 3228 0.0368559432497613 4653 3848840
SGTC_894 0960-0238 55.9 µM -1.79739688230665 0.0384952394603831 no 3229 0.0361363176722701 4619 6741907 YDL195W SEC31
SGTC_780 0109-0199 192 µM -1.80055545794574 0.0382334294714219 no 3230 0.0358864875380231 4643 610414
SGTC_876 0720-0963 56.8 µM -1.80162481171059 0.0381451218985109 no 3231 0.0358022274312497 4632 765861
SGTC_628 1636-0253 16 µM -1.80347419837248 0.0379927916263506 no 3232 0.0356568870051025 4620 4456143
SGTC_2838 9002687 71.43 µM -1.80507984313101 0.0378609407066841 no 3233 0.0355310943950557 4612 6457060
SGTC_2097 5376186 200 µM -1.80528845372377 0.0378438376474245 no 3234 0.0355147777478515 4611 742755
SGTC_15 0266-0086 27.098 µM -1.81089912702061 0.0373862036172953 no 3235 0.0350782338777894 4684 1712902 YIL048W NEO1
SGTC_1229 0139-0193 12.2 µM -1.81715537054492 0.0368812544906812 no 3236 0.0345966632126402 4670 3090752
SGTC_235 0330-0087 5 mM -1.81944764581056 0.0366976436951097 no 3237 0.034421581647218 4663 46494818 YHR062C RPP1
SGTC_203 k066-0004 30.888 µM -1.82224995593343 0.0364741956219732 no 3238 0.0342085338700512 4673 6795412
SGTC_1452 4194-0072 190 µM -1.83258004535884 0.0356601015773489 no 3239 0.0334325239565859 4668 1343545
SGTC_1612 st002233 45.4 µM -1.8360734771201 0.0353881841816598 no 3240 0.0331733951708024 4658 1035021
SGTC_649 1123-0311 367 µM -1.83713214425542 0.0353061174913864 no 3241 0.0330951949389907 4542 693629 YIL048W NEO1
SGTC_769 0302-0231 76 µM -1.8398928828109 0.0350928422167791 no 3242 0.0328919825655183 4574 571869 YER009W NTF2
SGTC_1626 st003712 1.76 µM -1.84605066905602 0.0346209423531107 no 3243 0.0324424243371371 4630 24207035
SGTC_348 k064-0012 10.7 µM -1.85684760875001 0.0338061094527732 no 3244 0.0316664190653228 4622 5066323
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.85805640577388 0.0337158731404863 no 3245 0.0315805023341335 4663 1273210
SGTC_1250 0485-0349 40.2 µM -1.85914453491291 0.0336348142421163 no 3246 0.0315033270811805 4623 6842794 YDL195W SEC31
SGTC_3272 9137413 49.47 µM -1.86092691080319 0.0335023848181431 no 3247 0.0313772494458871 4600 17614870
SGTC_336 4111-0029 111 µM -1.86307874702349 0.0333430769480669 no 3248 0.0312255939479027 4663 3131175
SGTC_169 k015-0017 16.025 µM -1.88323868502382 0.0318806587269309 no 3249 0.0298340143142637 4604 1840002
SGTC_2058 5236698 133 µM -1.8861760387064 0.031672070292052 no 3250 0.0296356181599075 4630 766665
SGTC_1460 k062-0059 9.15 µM -1.88988451876986 0.0314103343373041 no 3251 0.029386703239 4536 1373085
SGTC_3198 9112019 49.47 µM -1.89575402257557 0.0309997351959414 no 3252 0.0289962890661708 4681 45595555
SGTC_1840 st055363 71 µM -1.89718396553541 0.0309003797013848 no 3253 0.0289018311692919 4666 676033
SGTC_221 trifluoperazine 10.304 µM -1.89853670704487 0.0308066310745082 no 3254 0.0288127085383443 4646 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2705 st078069 42.8 µM -1.90049295190933 0.0306714746043535 no 3255 0.028684229518917 4655 1530061
SGTC_77 0828-0286 12.516 µM -1.90886482449905 0.0300985995228534 no 3256 0.028139765874127 4558 745345
SGTC_927 2425-1185 123 µM -1.92033372912597 0.0293282260284473 no 3257 0.0274078792714461 4628 730375
SGTC_2714 st079313 56.9 µM -1.92626282982932 0.028936429445949 no 3258 0.0270357820705757 4668 2939799
SGTC_2546 rhodinyl acetate 100 µM -1.92683568831273 0.028898806343497 no 3259 0.0270000551603946 4614 6708682
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.93713648770309 0.0282291999826301 no 3260 0.0263643307150258 4672 688751
SGTC_1320 1313-0481 95.3 µM -1.95008664793073 0.0274057452012171 no 3261 0.0255828961999005 4632 6813365 YLR208W SEC13
SGTC_2131 toluylene red 5.2905 µM -1.96162315551153 0.0266891431970199 no 3262 0.0249031871800717 4636 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1749 st037932 54.2 µM -1.97038799092996 0.0261552272033039 no 3263 0.0243969604252058 4652 594497
SGTC_1568 digitonin 820 nM -1.97518608688017 0.0258667503942427 no 3264 0.0241235171132374 4644 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1778 st046819 58.9 µM -1.99350512510632 0.024789725031429 no 3265 0.0231030814476939 4714 671715
SGTC_1818 st052136 56.3 µM -1.99915986458261 0.0244649634859082 no 3266 0.0227955297956863 4376 674169
SGTC_1230 0170-0365 3.77 µM -2.00440884237301 0.0241667090170778 no 3267 0.0225131414460104 4681 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_222 nsc-310342 10.666 µM -2.01229048529573 0.0237246026987162 no 3268 0.0220946624139136 4701 432556
SGTC_1780 st038448 24.544 µM -2.01612144288474 0.0235121802925943 no 3269 0.0218936391630172 4688 728868 YDL195W SEC31
SGTC_953 1188-0045 9.7 µM -2.01714529408253 0.0234556805730304 no 3270 0.0218401765274289 4654 6144426
SGTC_3263 9137018 49.47 µM -2.02880674951277 0.0228201811323779 no 3271 0.0212389887837448 4648 43844957
SGTC_2394 5221648 200 µM -2.02943453999684 0.0227863848059584 no 3272 0.0212070250254013 4680 788586
SGTC_693 4161-2696 114 µM -2.03852688506522 0.0223016197934393 no 3273 0.0207486344339248 4710 805759
SGTC_1658 st012944 20 µM -2.04111618776656 0.0221651713922732 no 3274 0.020619639866467 4567 24207260
SGTC_1371 2421-0008 32.7 µM -2.04367539400866 0.0220310019394873 no 3275 0.0204928128000647 4687 2827552
SGTC_3333 9141820 12.094 µM -2.04657022229484 0.0218800640960088 no 3276 0.0203501505424108 4674 1939433
SGTC_1558 st069300 45.6 µM -2.05793415060262 0.0212959587234813 no 3277 0.0197982274759908 4691 24208000
SGTC_2118 5526350 200 µM -2.05813702378858 0.0212856520381338 no 3278 0.0197884909213962 4695 743594
SGTC_2098 5376439 882.5 nM -2.06085202672183 0.0211481256444829 no 3279 0.0196585796193863 4717 2844116
SGTC_2961 9083290 32.55 µM -2.06502622405262 0.0209381514910417 no 3280 0.0194602595424617 4669 17741490
SGTC_805 3852-0218 479 µM -2.0662080046266 0.020879026006407 no 3281 0.019404421680644 4690 6615355
SGTC_1958 st076513 41.9 µM -2.06902140054178 0.020738837925321 no 3282 0.0192720392664813 4643 732122 YGL099W LSG1
SGTC_1653 st012112 65 µM -2.07056076561519 0.0206624711843969 no 3283 0.0191999309382084 4685 720429
SGTC_1055 3448-0672 86 µM -2.07610268217196 0.0203895101105539 no 3284 0.0189422275827721 4677 748378
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.07840090272239 0.020277213544981 no 3285 0.0188362248239413 4689 6312947
SGTC_1879 gemcitabine 100 µM -2.15614981424704 0.016775494408998 no 3286 0.015535984411706 4696 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1462 k081-0014 26.5 µM -2.15685558014576 0.0167462409945518 no 3287 0.0155084594526427 4175 3270634
SGTC_3173 9105693 49.47 µM -2.16495903657446 0.0164134745233535 no 3288 0.0151954112194191 4691 17096658
SGTC_2836 9010338 19.48 µM -2.17433147624071 0.0160356738730805 no 3289 0.014840125084747 4668 2994051
SGTC_1976 st070609 63.5 µM -2.1789272326094 0.0158531597800542 no 3290 0.0146685371780119 4703 682556
SGTC_2195 6536160 144.242 µM -2.18621050808471 0.0155675635342406 no 3291 0.0144001039181813 4739 3834386
SGTC_433 pimozide 108 µM -2.20104117304811 0.0149996411971477 no 3292 0.0138665545994331 4671 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.21254446397453 0.014571486653874 no 3293 0.0134645337414854 4720 23847180
SGTC_878 0828-0289 13.7 µM -2.22413398746937 0.0141508007103441 no 3294 0.0130697153966731 4717 745350 YLR208W SEC13
SGTC_135 0933-0004 26.348 µM -2.23893686882776 0.0136287259664516 no 3295 0.0125800120730609 4683 21230617 YGL099W LSG1
SGTC_407 eburnamonine 100 µM -2.24417316352746 0.0134480721077421 no 3296 0.0124106310031363 4644 3195
SGTC_1410 3909-8106 77.9 µM -2.25600426330233 0.0130474929572605 no 3297 0.0120351820677635 4761 1039210
SGTC_2460 5552655 174.22 µM -2.26258656639218 0.012829125864693 no 3298 0.0118305935017553 4717 5401989
SGTC_1506 4226-2149 212 µM -2.26606484888713 0.0127150161256456 no 3299 0.0117237065225426 4729 991114
SGTC_2296 7971656 126.45 µM -2.29449711626998 0.0118147430536463 no 3300 0.0108809802579614 4716 666570
SGTC_1847 st056231 15 µM -2.31478401808366 0.0112066829404088 no 3301 0.0103123774995268 4734 5393180
SGTC_931 2812-0076 566 µM -2.3201060404943 0.0110517427152169 no 3302 0.0101675708276582 4708 3450959
SGTC_2145 5634607 200 µM -2.32873649586853 0.0108044438069909 no 3303 0.00993651472158404 4755 308662
SGTC_105 0111-0055 734.78 µM -2.3663753939139 0.00978140899519726 no 3304 0.00898160999691454 4747 5179370
SGTC_761 k216-0224 480 µM -2.37112508439275 0.00965852361167494 no 3305 0.00886701413601374 4753 1340404
SGTC_2243 6634756 200 µM -2.38563672559756 0.00929139372571152 no 3306 0.00852479170473838 4736 885676
SGTC_2932 9016711 44.54 µM -2.39354477771431 0.00909651454755576 no 3307 0.00834322219856982 4732 7117328
SGTC_2119 5528445 120.635 µM -2.39995139397223 0.00894126911756762 no 3308 0.00819862449724939 4751 791935
SGTC_486 niguldipine 82 µM -2.40448571773092 0.00883280065520399 no 3309 0.00809761952013337 4783 1236 A calcium channel blocker.
SGTC_1277 0873-0036 22 µM -2.41304128167922 0.00863127507238761 no 3310 0.0079100138204021 4778 5965735
SGTC_1567 st069303 68.4 µM -2.41780110666632 0.00852091297149885 no 3311 0.00780730454413134 4738 5581319
SGTC_97 0535-0701 19.132 µM -2.43160202526553 0.00820789215060911 no 3312 0.00751610703001159 4693 2832013 YGL099W LSG1
SGTC_660 4031-1742 102 µM -2.44277264681138 0.00796197288879097 no 3313 0.00728745790357154 4677 6738706
SGTC_2411 st077133 39.94 µM -2.44328643025485 0.00795081955444737 no 3314 0.00727709049889307 4719 1403142 YNL221C POP1
SGTC_339 3091-4833 71.4 µM -2.47129790142254 0.00736316173889368 no 3315 0.00673118102198399 4602 3240077
SGTC_2835 9006588 71.43 µM -2.48165334581286 0.00715580729414483 no 3316 0.00653872140834539 4695 2345538
SGTC_648 0375-0473 33.3 µM -2.48258430584848 0.00713742082930414 no 3317 0.00652165996623017 4775 1713139
SGTC_2250 alverine citrate 130 µM -2.51134127915933 0.00658962092599025 no 3318 0.00601366791481956 4655 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2686 alizarin 95.37 µM -2.52861744724996 0.00627870071790797 no 3319 0.0057256383098714 4746 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2303 7774051 200 µM -2.58201060329208 0.00539830347811553 no 3320 0.00491132834812539 4750 2953184
SGTC_515 4092-1064 102 µM -2.58747146146981 0.00531475964636664 no 3321 0.00483416020986043 4720 717353
SGTC_2772 vinpocetine 57.06 µM -2.5933268845627 0.00522645876655828 no 3322 0.00475261894400173 4753 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2581 avocatin a 64 µM -2.60902973235171 0.00499606694604796 no 3323 0.00453996763574128 4719 6710728 A skin care supplement.
SGTC_325 2810-4341 181 µM -2.62663608582926 0.00474854182647857 no 3324 0.00431167515862337 4784 774970
SGTC_101 0490-5701 117.494 µM -2.63467544418831 0.0046392000131043 no 3325 0.00421088838974175 4729 4661669
SGTC_1855 st056195 39.6 µM -2.64562409276976 0.00449390407343053 no 3326 0.00407701865515585 4736 4028379
SGTC_3221 9128209 49.47 µM -2.64914279389916 0.00444807906078353 no 3327 0.00403481139610353 4771 16460723
SGTC_108 0509-0257 621.132 µM -2.65100362124577 0.00442401411864922 no 3328 0.0040126490481502 4766 536624
SGTC_588 3970-1144 52.9 µM -2.72304404339228 0.00357730959185564 no 3329 0.003234171695508 4753 1888707
SGTC_109 0132-0036 33.701 µM -2.72431000046934 0.003563829668515 no 3330 0.00322179967721679 4761 67274 A color developer.
SGTC_2282 7944268 200 µM -2.73759753265863 0.00342507078605417 no 3331 0.00309448826073421 4763 2970414
SGTC_1594 piperine 70.1 µM -2.75006291315493 0.00329933088333938 no 3332 0.00297919117983584 4779 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2697 mebhydrolin 72.4 µM -2.77075735197571 0.00309972488502639 no 3333 0.00279630429897179 4771 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2927 9011802 47.9 µM -2.77970858988937 0.00301680706148856 no 3334 0.00272038492292241 4743 43912568
SGTC_990 3985-0011 41.3 µM -2.80268905648259 0.0028130065225871 no 3335 0.00253392519036578 4775 5399565 YGL099W LSG1
SGTC_1077 5-fluorocytosine 377 nM -2.85075396537033 0.00242638113478546 no 3336 0.0021807851906942 4795 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2587 piperic acid 92.2 µM -2.88655012228489 0.00217040933889681 no 3337 0.0019474535200071 4764 5370536
SGTC_1645 Cervolide 78 µM -2.91201905727287 0.00200346861518131 no 3338 0.00179550362900865 4801 23173 A fragrance.
SGTC_230 MPP+ 141.667 µM -2.92434360346652 0.00192694694638934 no 3339 0.00172591744286872 4794 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1052 3253-3998 198 µM -2.93147412544682 0.00188389647741982 no 3340 0.00168678733981149 4777 5450317
SGTC_1876 myriocin 605 nM -2.97637952389664 0.00163227965881589 no 3341 0.00145836828856046 4774 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_779 1360-0071 233 µM -3.01789347023232 0.00142731185787626 no 3342 0.00127269182800121 4788 7566
SGTC_2883 9059145 45.46 µM -3.07058926099897 0.00120103252088023 no 3343 0.0010681840903741 4785 16476510
SGTC_2924 9010168 62.78 µM -3.08263916577523 0.00115413533969021 no 3344 0.00102586885438568 4777 2993929
SGTC_182 3448-4371 550.524 µM -3.10331529171158 0.00107755644254948 no 3345 0.000956828239091842 4773 3491403
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -3.11962844226869 0.00102045586654163 no 3346 0.000905396474050845 4795 688669
SGTC_2897 9048598 12.99 µM -3.18442633709516 0.000820004444222883 yes 3347 0.000725206103078096 4792 6467404
SGTC_1129 3453-1384 223 µM -3.19478642365855 0.000791543056399381 yes 3348 0.000699671770243735 4782 1084452
SGTC_809 3998-0021 90 µM -3.20436520010102 0.000766040111378549 yes 3349 0.00067680329727564 4791 715485
SGTC_113 0099-0221 2.5 µM -3.27385528917872 0.00060251029350106 yes 3350 0.000530454635556414 4790 89219
SGTC_1881 5652484 16 µM -3.29813364508998 0.000553440058914113 yes 3351 0.000486648986177801 4795 2255129
SGTC_2585 alliin 100 µM -3.87107744532351 6.35521964380663e-05 yes 3352 5.41776786559937e-05 4801 87310 A garlic compound which reacts with lipids.
SGTC_2783 7738165 71.43 µM -3.88645965608286 5.97109366776457e-05 yes 3353 5.08584110182877e-05 4797 17201110
SGTC_2418 pentamidine 31.67 µM -4.01731004624548 3.48184422551059e-05 yes 3354 2.94331259947371e-05 4801 4735 Thought to act by inhibiting tRNA aminoacylation and translation.