SGTCid condition conc unit ASG7|YJL170C.score ASG7|YJL170C.strain.pval ASG7|YJL170C.strain.significant ASG7|YJL170C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_132 0417-1715 25.805 µM 6.65017535679805 7.4049998488541e-11 yes 1 1.46372013718504e-11 2 6769098
SGTC_3001 9076041 71.4286 µM 5.43449145465191 8.24118676607103e-08 yes 2 2.7476465236235e-08 4 16004211
SGTC_1666 st014829 29 µM 5.01701608285547 6.73608341241764e-07 yes 3 2.62400880569066e-07 14 3858230
SGTC_1767 st044992 70.3 µM 4.71815646058253 2.75323948334254e-06 yes 4 1.18995717799779e-06 11 9600693
SGTC_2105 5350118 200 µM 4.52274980940673 6.62012062860619e-06 yes 5 3.0520688821425e-06 16 2133313
SGTC_1913 st060213 96.1 µM 4.29804276488121 1.7407864174913e-05 yes 6 8.61564613697096e-06 21 688959
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 4.28432161596191 1.84396399654189e-05 yes 7 9.16488019766545e-06 25 5377381
SGTC_870 0573-2213 57.6 µM 4.26381602820264 2.009040674911e-05 yes 8 1.00482463678752e-05 13 3916321
SGTC_949 1165-0505 146 µM 4.23834983784075 2.2336097324024e-05 yes 9 1.12584354954858e-05 15 6244267
SGTC_2168 5727979 200 µM 4.23531783500884 2.26188022851164e-05 yes 10 1.14114329739568e-05 14 695210
SGTC_538 2922-0838 53.3 µM 4.12375425280438 3.572685784609e-05 yes 11 1.86373290912627e-05 29 777039
SGTC_371 0195-0006 7.36 µM 4.03992613778993 5.00051048807684e-05 yes 12 2.67340186774968e-05 19 3928593
SGTC_137 0438-0332 85.389 µM 3.82771961272686 0.000113920344452963 yes 13 6.46679847477037e-05 133 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2123 5259487 200 µM 3.82335832110523 0.000115816273788411 yes 14 6.58231248242988e-05 21 2173474
SGTC_2810 7959871 45.46 µM 3.79602348812119 0.000128390234617703 yes 15 7.35177868584152e-05 43 2974535
SGTC_1911 st060208 74.3 µM 3.7849468835288 0.000133841032366149 yes 16 7.68707058254844e-05 40 688783
SGTC_147 4466-0538 29.23 µM 3.75538132187587 0.000149471393436191 yes 17 8.65388802639322e-05 26 6742687 YHR072W ERG7
SGTC_1339 1486-1321 22.7 µM 3.73528201397765 0.000161056303902552 yes 18 9.3752470274918e-05 28 3469382
SGTC_2868 9035608 32.47 µM 3.63855020192071 0.000229534653544085 yes 19 0.000137088593401455 23 6462614
SGTC_2453 5731132 22.18 µM 3.61759165359455 0.000247580793504748 yes 20 0.000148678523335989 27 1362040
SGTC_3027 9089541 49.47 µM 3.56926544508974 0.000294353042681885 yes 21 0.00017899178265667 31 9943819
SGTC_3007 9078383 71.4286 µM 3.56158629037882 0.000302502194806491 yes 22 0.000184310457546699 29 6496995
SGTC_294 k038-0071 157 µM 3.45785094343664 0.000435258318173405 yes 23 0.000272251275753172 79 24152826
SGTC_2154 5570129 200 µM 3.3937139956437 0.000542506154587976 yes 24 0.00034475831428138 39 673366
SGTC_2851 9015922 71.43 µM 3.36749551262862 0.000593007364825431 yes 25 0.000379271304426411 67 2996893
SGTC_151 3013-0144 2.285 µM 3.3069194559555 0.000726736821250751 yes 26 0.000471640049262035 51 906558 YHR107C CDC12
SGTC_1902 st060212 70.5 µM 3.30579078836481 0.000729473564924715 yes 27 0.000473543870396106 30 688944
SGTC_2152 5568786 200 µM 3.30174578480726 0.000739359917246672 yes 28 0.000480425555084958 31 5399883
SGTC_2499 avocadenofuran 51.48 µM 3.30080886411921 0.00074166737694187 yes 29 0.000482032676240718 67 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1847 st056231 15 µM 3.23562237928397 0.000919497805642069 yes 30 0.000606889210770924 65 5393180
SGTC_958 1222-0007 33 µM 3.17121351578315 0.00113293944833806 no 31 0.000759017598818432 55 7312461
SGTC_2683 piperine 63.03 µM 3.12738882814054 0.00130316251187841 no 32 0.000881832531643385 36 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3140 9094243 49.47 µM 3.11791655381953 0.00134289900692859 no 33 0.000910671818530804 61 19291112
SGTC_541 4513-1321 94 µM 3.09564002870431 0.00144075075809532 no 34 0.000981943095238123 54 747515
SGTC_531 3788-1495 174 µM 3.05855913871817 0.00161815991805124 no 35 0.00111202088519064 63 2896655
SGTC_2624 nerol 100 µM 3.00935419038734 0.00188429379555975 no 36 0.00130901855250308 42 637566 A natural product oil.
SGTC_509 pifithrin 175 µM 2.98968619629728 0.00200136991432528 no 37 0.00139632092079427 27 4817 A p53 inhibitor.
SGTC_2150 5556613 200 µM 2.94513177002082 0.00229137603439166 no 38 0.00161408574111409 60 743190
SGTC_3020 9089140 49.47 µM 2.91477452022396 0.00251023567620343 no 39 0.00177972803348074 76 17217859
SGTC_2943 9068529 45.32 µM 2.88818311392036 0.00271728884006059 no 40 0.00193737115096436 78 3270634
SGTC_131 0141-0277 33.849 µM 2.85257351418658 0.00301868995193656 no 41 0.00216833901684371 116 1547771
SGTC_2629 bisabolol 100 µM 2.8510062403526 0.00303262207576157 no 42 0.00217905570773327 84 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2621 lithochol-11-enic acid 100 µM 2.84718835819583 0.00306680346924203 no 43 0.00220536281701983 94 6708711
SGTC_1534 6-azauridine 81.6 µM 2.82672839776959 0.00325596195477474 no 44 0.00235130975026592 86 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1510 1123-0200 71.5 µM 2.82232449819133 0.00329802484257084 no 45 0.00238384545108436 117 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1363 1636-0063 10.4 µM 2.82093086953161 0.00331143720251074 no 46 0.00239422603165807 96 6072185
SGTC_1657 st012939 43.4 µM 2.80977839244111 0.0034205482310933 no 47 0.00247878113433144 51 24207257
SGTC_1927 st060202 13.8 µM 2.77632560382262 0.00376747711771632 no 48 0.00274885601401878 77 688887
SGTC_88 0180-0332 8.668 µM 2.75146372209892 0.00404540966131844 no 49 0.00296647954434048 79 3101745
SGTC_2630 antimycin a 100 µM 2.73986482066608 0.00418124513297293 no 50 0.00307322292501406 114 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1377 2944-0135 198 µM 2.72513051763573 0.00435967558401002 no 51 0.00321380363869602 120 1894137
SGTC_2062 5245942 200 µM 2.7242618539755 0.00437040432458822 no 52 0.00322226942605171 86 1376160
SGTC_152 4469-0003 551.229 µM 2.6954992621666 0.00473923820013813 no 53 0.00351416167241369 79 697280
SGTC_2582 agaric acid 100 µM 2.68724610489641 0.00485007722704304 no 54 0.00360219247926448 497 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_256 clotrimazole 625 nM 2.68150467312671 0.00492854100887661 no 55 0.00366459453825129 108 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2513 baicalein 25.65 µM 2.67705025593222 0.00499019320515201 no 56 0.00371367466585131 92 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_521 r062-0005 13.8 µM 2.66620432964361 0.00514318996560108 no 57 0.00383565260293003 74 2832033
SGTC_2340 7987427 183.45 µM 2.6643772265154 0.00516937072480877 no 58 0.00385655077828317 111 2239331
SGTC_2055 5235184 200 µM 2.65837485320253 0.00525621618074759 no 59 0.00392592529513481 108 2836034
SGTC_2959 9079155 11 µM 2.65683494853398 0.00527870448279251 no 60 0.00394390252502909 92 16189457
SGTC_2151 5563267 85.4165 µM 2.63705129367748 0.00557532517353185 no 61 0.00418150923654173 99 5310824
SGTC_91 0417-1751 58.384 µM 2.63689949989827 0.00557765715737695 no 62 0.00418338078236869 153 6795624
SGTC_1166 k206-0078 225 µM 2.62935344427197 0.00569468360770614 no 63 0.00427736983437356 101 5404595
SGTC_1665 st014639 11.4 µM 2.62896929388599 0.00570069900776682 no 64 0.00428220468801066 111 981133 YIL048W NEO1
SGTC_136 0097-0015 404.482 µM 2.62011891514741 0.00584085771583301 no 65 0.00439495551784329 109 4861337
SGTC_3083 9117465 49.47 µM 2.61864575037658 0.0058644818992972 no 66 0.00441397851007694 125 16420915
SGTC_1366 1683-0113 21.9 µM 2.618552869978 0.0058659741981077 no 67 0.00441518033710693 73 708623
SGTC_2153 5569715 200 µM 2.60805889168296 0.00603676409026503 no 68 0.00455286434710532 65 2054701
SGTC_1740 st038286 13.222 µM 2.60471773221724 0.00609205909396746 no 69 0.00459749885664325 117 716786
SGTC_286 k060-0067 22.9 µM 2.60236391625953 0.00613128291710021 no 70 0.00462917752370498 94 5985051
SGTC_122 0236-0016 402.397 µM 2.59868796966266 0.00619298626220656 no 71 0.0046790397175488 151 6808838
SGTC_1970 st070122 35.8 µM 2.57422381833542 0.00661782689941927 no 72 0.00502326296195972 120 102928
SGTC_158 k038-0087 26.446 µM 2.57333292449223 0.00663377287274209 no 73 0.0050362132674408 256 X158
SGTC_1097 itavastatin 7.23 µM 2.56706084899422 0.00674700033024786 no 74 0.00512823062574661 99 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.56402287743178 0.006802455062931 no 75 0.00517333622586381 128 5379071
SGTC_2682 pyrogallin 40.03 µM 2.5551437135754 0.00696684910958573 no 76 0.00530719817666889 133 822798 An ATP competetive kinase inhibitor.
SGTC_1266 0828-0227 32.9 µM 2.54247208744197 0.00720753138772404 no 77 0.00550356962160967 110 3913820
SGTC_1802 st050112 57.9 µM 2.53328967199768 0.00738649358527909 no 78 0.00564987652169421 78 4662563
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.53033775547151 0.00744485147091528 no 79 0.00569763864848134 127 3256 An antibiotic and ribosome inhibitor.
SGTC_2657 nystatin 74.44 µM 2.52232385305321 0.00760533554909485 no 80 0.00582911609374417 98 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2016 5121758 140 µM 2.51780943875125 0.00769707473325472 no 81 0.00590435953912559 163 2795203
SGTC_142 0335-0849 62.6745 µM 2.51592686140985 0.00773561821293175 no 82 0.00593599082390031 260 3889043 YPR107C YTH1
SGTC_411 enrofloxacin 100 µM 2.51435104929378 0.00776801154371918 no 83 0.00596258324045205 77 71188 A bacterial gyrase inhibitor.
SGTC_2488 5268135 45.7 µM 2.50022541355167 0.00806375798290229 no 84 0.00620571532242542 160 1270356 YLR208W SEC13
SGTC_2226 7298446 200 µM 2.49875785434172 0.00809504442028868 no 85 0.00623147186362446 62 3283010
SGTC_2945 9067681 61.76 µM 2.48689067495301 0.00835198071072357 no 86 0.00644324963775105 80 16456930
SGTC_1409 3909-8004 61.9 µM 2.47369654709832 0.00864602754789509 no 87 0.00668616128533119 138 2119279
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.46346818008968 0.00888018802807538 no 88 0.0068800054278698 146 165506
SGTC_2618 avocadyne 43.43 µM 2.46103565177608 0.00893668776151443 no 89 0.00692682994424568 111 3015189
SGTC_871 0574-0004 149 µM 2.454039133651 0.00910095344978364 no 90 0.00706308037850526 165 9551173
SGTC_475 α-linolenic acid 10 µM 2.43949725200886 0.00945084926208223 no 91 0.0073538572659796 125 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_555 4296-0685 37 µM 2.42100735580773 0.00991268788512106 no 92 0.00773878204335671 94 2908540 YHR072W ERG7
SGTC_2479 5617353 43.85 µM 2.41800091581856 0.00998961598643269 no 93 0.0078030187687122 152 2731746
SGTC_6 0844-0013 19.835 µM 2.41786956004459 0.00999298893714499 no 94 0.00780583603084011 323 1584900
SGTC_2560 caryophyllene 100 µM 2.41781675353655 0.00999434518163227 no 95 0.00780696885428871 127 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2830 7992007 71.43 µM 2.41205570719616 0.0101432760332778 no 96 0.00793142881257511 121 1952075
SGTC_2935 9038016 29.96 µM 2.40380811194156 0.0103598563019925 no 97 0.00811264377748071 134 6463195
SGTC_1903 st060211 78.3 µM 2.39442894733532 0.0106110405685834 no 98 0.00832313417098334 144 688960
SGTC_2087 5276107 200 µM 2.36690524506091 0.0113790217612672 no 99 0.00896876230173106 117 144405
SGTC_1757 st041620 31.8375 µM 2.35939116974986 0.0115968988929197 no 100 0.00915247457026988 152 5289815
SGTC_1876 myriocin 605 nM 2.35168567754774 0.0118240791649403 no 101 0.00934427985464448 138 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_406 estrone 100 µM 2.35102229309913 0.0118438169870244 no 102 0.00936095606963215 112 5870 A steroid.
SGTC_2287 7945887 168.79 µM 2.32578316207553 0.0126162980292542 no 103 0.0100150606733647 113 1245853
SGTC_175 3793-3120 23.7 µM 2.32473945378892 0.0126491601458292 no 104 0.0100429481271388 146 5322297
SGTC_3134 9127454 49.47 µM 2.32450962354694 0.0126564065070877 no 105 0.0100490981931276 104 24262820
SGTC_3182 9108849 49.47 µM 2.31333568162581 0.0130130722213154 no 106 0.0103520951728069 147 17133045
SGTC_275 trichlorophene 5.69 µM 2.31248197954085 0.0130406757343798 no 107 0.0103755686289249 377 62616
SGTC_2507 purpurin 79.67 µM 2.31177531843031 0.0130635631150375 no 108 0.010395034122329 182 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3029 9088683 49.47 µM 2.30006554314372 0.0134479052165848 no 109 0.0107222535185079 145 25236615
SGTC_792 4534-1957 155 µM 2.29960252991099 0.0134633009653096 no 110 0.0107353743196122 162 1717904
SGTC_2102 5377816 72.7585 µM 2.29940860387774 0.0134697537599984 no 111 0.0107408739196096 149 1379702
SGTC_985 1493-0307 8.71 µM 2.29455203636716 0.0136322266621373 no 112 0.0108794048420595 102 3278274
SGTC_3184 9108758 49.47 µM 2.29377574676328 0.0136583530032498 no 113 0.0109016916124103 92 902885
SGTC_481 bay k-8644 50 µM 2.28804676326175 0.0138525036094304 no 114 0.0110673989957523 151 2303 A calcium channel antagonist.
SGTC_160 3453-0671 289.699 µM 2.28709310399025 0.0138850523413707 no 115 0.0110951946580615 184 5322268
SGTC_177 1327-0068 8.361 µM 2.26098220176956 0.0148022035417525 no 116 0.0118801796086511 208 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1173 0443-0020 122 µM 2.25036181981699 0.015189890133097 no 117 0.0122129932935536 199 5331295
SGTC_1273 0849-0096 14.1 µM 2.2474174966392 0.0152989020150657 no 118 0.0123066789252552 156 5286025
SGTC_2930 9013230 14.89 µM 2.24607804370502 0.0153487164322728 no 119 0.0123495047177522 200 2995857
SGTC_1730 st033808 45.1 µM 2.23673717452412 0.0156999920759218 no 120 0.0126517614150594 223 1045166
SGTC_400 oxethazaine 37.5 µM 2.23266734011729 0.0158551875222057 no 121 0.0127854448694981 152 4621 A local anesthetic.
SGTC_663 1486-0733 13.9 µM 2.22949987170348 0.0159768815648076 no 122 0.0128903319178887 218 722445 YPR165W RHO1
SGTC_2506 ethyl hematommate 54.16 µM 2.20890416729435 0.0167878603074281 no 123 0.0135906536458235 141 3940691 An allergen.
SGTC_3141 9094609 49.47 µM 2.20524164612887 0.0169357038891443 no 124 0.0137185711112991 191 25236309 YDL196W YDL196W
SGTC_62 0180-0423 3.232 µM 2.1956740232421 0.0173271786852474 no 125 0.0140576418793673 160 30102 YGL099W LSG1
SGTC_1123 mangostin 811.285 nM 2.19451590407434 0.0173750853469793 no 126 0.0140991709339018 208 5281650 An antioxidant.
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.18232812645955 0.0178861402630201 no 127 0.014542662308895 209 65057 A dermal irritant. YDR527W RBA50
SGTC_3285 9112818 20.8695 µM 2.17763520800157 0.0180863132207697 no 128 0.014716603074858 186 17017947 YPR165W RHO1
SGTC_939 1165-0479 45.3 µM 2.1583715423275 0.0189281178655925 no 129 0.0154494782203361 215 1377347
SGTC_1689 st020265 53.493 µM 2.15344969469188 0.0191484677366439 no 130 0.0156416768037358 144 5758320 YPR016C TIF6
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.14915575687868 0.0193424837728639 no 131 0.0158110275593597 145 17037758
SGTC_2904 7225135 42.03 µM 2.14560398150763 0.0195042260506921 no 132 0.0159522937624566 133 4446116
SGTC_2916 7875993 68.79 µM 2.13361078955415 0.0200588916799628 no 133 0.0164373270186942 197 1299250
SGTC_1065 prochlorperazine maleate 2.48 µM 2.1055741211888 0.0214079375477106 no 134 0.0176206812814331 192 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_125 0133-0007 11.75 µM 2.10512339040843 0.0214302371090261 no 135 0.0176402843286819 164 26541
SGTC_3350 9150499 3.57 µM 2.10506379555706 0.0214331869881097 no 136 0.0176428776025875 256 4910996 YPR165W RHO1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.10240235752802 0.0215652756352779 no 137 0.0177590224291575 202 688751
SGTC_2281 7943571 200 µM 2.10054641095177 0.0216577938893219 no 138 0.0178404012287544 176 1244024
SGTC_448 monastrol 171 µM 2.08992463760749 0.0221937607774722 no 139 0.0183122850029438 164 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1668 st014914 51.6 µM 2.08881569044064 0.0222503572477519 no 140 0.0183621587196136 156 2839556
SGTC_2366 9070441 60.58 µM 2.06871393210315 0.0232975720194194 no 141 0.0192864695239138 224 6837235
SGTC_1871 st057448 67.3 µM 2.06519668146749 0.023485004812581 no 142 0.0194521971986158 216 691747
SGTC_2471 5466956 24.79 µM 2.0642186607632 0.0235373479826794 no 143 0.0194984944944052 147 724419
SGTC_2201 6605497 169.863 µM 2.05897375162523 0.0238197299541784 no 144 0.0197483765254342 148 670741
SGTC_1104 tacrolimus 29.8 µM 2.05836002920675 0.0238529576646359 no 145 0.0197777928439973 215 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2750 bromebric acid 70.15 µM 2.05154126578795 0.0242247625503232 no 146 0.0201071326445096 237 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2223 6903751 107.57 µM 2.04528917947392 0.0245699340384359 no 147 0.0204131784271406 134 5598863
SGTC_3066 9117245 49.47 µM 2.04119613287436 0.0247981352369334 no 148 0.0206156679747708 193 17176980
SGTC_845 0330-0138 4.51 µM 2.03647227422553 0.0250637135302129 no 149 0.0208514772216223 193 9039800
SGTC_2540 epiandrosterone 100 µM 2.03314835009712 0.0252520122783072 no 150 0.0210187687115561 309 441302 A steroid.
SGTC_1731 st035964 63 µM 2.03201066089961 0.0253167335187164 no 151 0.0210762883470902 222 6739575
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.02608421400321 0.0256561307732511 no 152 0.0213780777445806 253 676296 Flavone; oxidizing agent.
SGTC_580 1123-0028 41 µM 2.02435413377951 0.025755924760071 no 153 0.0214668637073825 294 1677248 YPR107C YTH1
SGTC_1100 amiodarone 5.07 µM 2.02344148451069 0.0258086986907147 no 154 0.0215138253924383 226 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1502 4534-4282 27.7 µM 2.02289086404457 0.0258405820565491 no 155 0.0215422003387615 179 3278949
SGTC_2457 5731572 11.68 µM 2.02036303573165 0.0259873778066624 no 156 0.0216728723385768 155 2865357
SGTC_1063 disulfiram 1.84 µM 2.01635556809368 0.0262215282314906 no 157 0.0218814040654476 215 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_689 0833-0039 98 µM 2.01384019444243 0.0263693969067145 no 158 0.0220131570945838 210 5374726
SGTC_1149 3909-7961 23.3 µM 2.01278206233881 0.0264318081531119 no 159 0.0220687808978342 217 735261
SGTC_2961 9083290 32.55 µM 1.99082957452627 0.0277547221146076 no 160 0.0232498133957974 197 17741490
SGTC_471 1-acyl-paf 4 µM 1.99029781560907 0.0277874395507872 no 161 0.0232790692533873 221 16759367
SGTC_2586 curcumin 80 µM 1.98677392838625 0.0280050661345953 no 162 0.0234737275160911 305 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_557 1315-0110 16.2 µM 1.96759279599357 0.0292146780659332 no 163 0.0245574546479301 232 6833801
SGTC_200 k038-0079 37.545 µM 1.96689093259667 0.0292597498649812 no 164 0.0245978930566078 233 3436683
SGTC_1473 k844-0725 134 µM 1.9643264024098 0.0294249284837695 no 165 0.0247461258716601 247 54682906
SGTC_893 0958-0369 48.9 µM 1.95955243611838 0.0297344765443679 no 166 0.0250240626789691 261 6819948
SGTC_1006 4099-6547 255 µM 1.95644404246304 0.0299374761666912 no 167 0.025206434106361 232 3146833
SGTC_2007 4011539 71.82 µM 1.95640643924118 0.0299399389362921 no 168 0.025208647111404 259 45595301
SGTC_1305 1181-0477 144 µM 1.95484943832407 0.0300420601094939 no 169 0.0253004219522752 211 6252086
SGTC_1922 5578187 25 µM 1.95088780126901 0.0303032004245499 no 170 0.0255351970442048 258 1350412
SGTC_2992 9074591 71.4286 µM 1.94274065250736 0.030846152389885 no 171 0.026023750877205 191 17741321
SGTC_770 0389-1121 67.2 µM 1.9404612248534 0.0309994943562669 no 172 0.0261618310702449 289 6753108
SGTC_3022 9087993 49.47 µM 1.93445298931171 0.0314067060721148 no 173 0.0265287283749475 188 17173644
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.93367526957482 0.031459738328711 no 174 0.0265765331595792 188 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_20 0481-0013 4.944 µM 1.9324507051858 0.0315433906981561 no 175 0.0266519503953595 250 182045
SGTC_1531 st059297 52.4 µM 1.93242936982992 0.0315448497856743 no 176 0.0266532659584959 231 7566702
SGTC_1395 3486-0190 4.35 µM 1.93234464562757 0.0315506444757102 no 177 0.0266584906878414 233 6748079
SGTC_1163 k060-0048 49.9 µM 1.92925619500024 0.0317624796153399 no 178 0.0268495324871208 270 6809982
SGTC_1154 4088-0362 150 µM 1.92575687540478 0.0320039145817258 no 179 0.0270673692433928 309 6618304
SGTC_2082 5219693 150 µM 1.92559363432922 0.0320152142679359 no 180 0.0270775670940226 265 2834649
SGTC_484 loperamide 105 µM 1.92367250060246 0.0321484444750397 no 181 0.0271978235305666 117 3955 An opioid-receptor agonist.
SGTC_1736 st036774 51 µM 1.92043374669616 0.0323740873940496 no 182 0.0274015671584198 255 1272247
SGTC_1084 voriconazole 435 nM 1.91570109339615 0.032706158354983 no 183 0.0277015765947573 218 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1725 st036284 20.55 µM 1.90951427890742 0.0331444924920328 no 184 0.0280978907573102 284 707914
SGTC_1179 1021-1431 9.29 µM 1.90575673493266 0.0334130678210095 no 185 0.028340887303609 317 2840958
SGTC_2089 5281248 129.67 µM 1.90572594607765 0.0334152758738942 no 186 0.0283428855884092 254 2737878
SGTC_1868 st057644 42.7 µM 1.86896412948054 0.0361387010172473 no 187 0.0308139025432002 286 688665
SGTC_2198 6589944 200 µM 1.8688638995782 0.036146367629667 no 188 0.0308208759803752 197 5290268
SGTC_118 0083-0097 135.343 µM 1.8645451426906 0.0364779775764607 no 189 0.0311225941581202 523 5207356
SGTC_2674 ligustilide 100 µM 1.8597484625918 0.0368491977870883 no 190 0.0314605609989519 200 5319022 A signalling regulator.
SGTC_850 0388-0143 75.9 µM 1.8589059398036 0.0369147193770198 no 191 0.0315202360142803 240 67273
SGTC_21 0849-0113 22.993 µM 1.85575240793355 0.0371608102599434 no 192 0.0317444284977569 279 1560156
SGTC_977 1348-1378 135 µM 1.84821910888613 0.0377541124444968 no 193 0.0322853260714015 260 X977
SGTC_1250 0485-0349 40.2 µM 1.84521411994891 0.0379929242791856 no 194 0.032503198654826 286 6842794 YDL195W SEC31
SGTC_2423 st077119 87.2 µM 1.83858072034412 0.0385244563357897 no 195 0.0329884395762873 265 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1304 1165-0502 251 µM 1.83578828936198 0.0387500181218809 no 196 0.0331944870508504 325 767425
SGTC_2008 4012253 172 µM 1.834256287325 0.0388742236369604 no 197 0.0333079798031929 310 603940
SGTC_3280 9140961 49.47 µM 1.83334979938073 0.0389478687857293 no 198 0.0333752839921446 224 4901226
SGTC_872 0588-0139 234 µM 1.82673110982674 0.0394890356438832 no 199 0.0338701041596087 306 2047100
SGTC_2107 5363541 170.161 µM 1.82473988256744 0.0396530369232275 no 200 0.0340201458576015 271 244052
SGTC_1483 3453-0561 55.9 µM 1.82424409227896 0.0396939571634681 no 201 0.0340575892035681 300 4546991
SGTC_1477 0139-0234 16 µM 1.822285290857 0.039855963518251 no 202 0.0342058544412651 249 620880
SGTC_779 1360-0071 233 µM 1.8183773447984 0.0401807833014576 no 203 0.0345032392926646 286 7566
SGTC_1018 4259-0013 28.1 µM 1.81810438540097 0.0402035511942056 no 204 0.0345240899319508 261 6801262
SGTC_2799 7812892 81.82 µM 1.81177398856763 0.0407345239202142 no 205 0.035010562919011 293 20205235
SGTC_900 1112-0045 141 µM 1.80562180847429 0.0412559870294513 no 206 0.0354887168870712 204 56211 YIL048W NEO1
SGTC_2645 abamectin 100 µM 1.80315377625807 0.0414666943228377 no 207 0.035682033789768 300 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2733 amorolfine 100 µM 1.79959939569415 0.0417716795925392 no 208 0.0359619582913838 141 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1156 4092-0367 4.88 µM 1.79931697552249 0.0417959904891475 no 209 0.0359842771617595 312 1357585
SGTC_611 3453-1652 23.7 µM 1.79851089963973 0.041865441007777 no 210 0.0360480414785122 326 1560575
SGTC_3194 9111903 49.47 µM 1.79439746100239 0.0422213062911533 no 211 0.036374875948635 286 17087251
SGTC_520 3584-0023 682 µM 1.78096383045575 0.0434005679535692 no 212 0.0374591798731883 289 1340790
SGTC_2210 7115885 190.385 µM 1.7791085337443 0.0435655038140884 no 213 0.0376109849468196 279 2927039
SGTC_2414 st077232 92.9 µM 1.77786299851532 0.0436765154246544 no 214 0.0377131792991985 296 729801
SGTC_1443 4112-3303 14 µM 1.77722701235852 0.0437332873352911 no 215 0.0377654483888907 299 704433
SGTC_769 0302-0231 76 µM 1.77657367973641 0.0437916696758908 no 216 0.0378192046668926 376 571869 YER009W NTF2
SGTC_3085 9117376 49.47 µM 1.77650542982778 0.0437977721693602 no 217 0.0378248238773588 288 16480349
SGTC_3317 9138495 8.753 µM 1.77479028851702 0.0439513550929325 no 218 0.0379662602317975 309 17020139
SGTC_3041 9091929 49.47 µM 1.7695175278018 0.0444262280317881 no 219 0.0384037741719797 314 25236887
SGTC_2813 7971799 71.43 µM 1.76036240953839 0.0452605660059859 no 220 0.0391731893225386 277 2234054
SGTC_329 k048-0121 21.3 µM 1.75442810156091 0.0458080817032079 no 221 0.0396785898249784 289 6832902
SGTC_197 4544-0043 41.561 µM 1.7516041339347 0.0460704915225181 no 222 0.0399209506276189 360 896523
SGTC_401 neomycin 50 µM 1.74801617745388 0.0464056331870111 no 223 0.0402306130909392 262 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1194 1488-0194 225 µM 1.71942145867115 0.0491470529845534 no 224 0.0427688288325651 367 1391452
SGTC_2435 5706476 10.6 µM 1.71665094068513 0.0494194006282524 no 225 0.0430214844788004 338 5725375
SGTC_3147 9097027 49.47 µM 1.71397916853671 0.0496831811645186 no 226 0.0432662758822604 316 25236841
SGTC_1507 4075-3230 155 µM 1.70925741083948 0.0501520999794449 no 227 0.0437016392790619 247 659771
SGTC_3196 9111891 49.47 µM 1.70708329462642 0.0503691949608256 no 228 0.0439032858244923 277 18891510
SGTC_2174 5790901 200 µM 1.70699358876311 0.0503781685439474 no 229 0.0439116220245121 340 786020
SGTC_2185 6113692 200 µM 1.70278151915737 0.0508009523732813 no 230 0.0443044813074672 287 874150
SGTC_441 propafenone 146 µM 1.694336917298 0.0516570811151557 no 231 0.0451006396127593 263 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2526 patulin 37.61 µM 1.69298322197216 0.0517953817604302 no 232 0.0452293304354156 434 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_692 k241-0027 77.8 µM 1.69099209076864 0.0519993408119861 no 233 0.045419156624665 312 3600480
SGTC_1438 4092-1045 4 µM 1.68822121823966 0.0522842329647511 no 234 0.0456843858036686 306 1351342
SGTC_2878 9043973 25.97 µM 1.68618562707858 0.0524943145287132 no 235 0.0458800256878057 289 6465167
SGTC_933 2914-0560 114 µM 1.68511512909964 0.0526050629545697 no 236 0.0459831806325941 369 463887
SGTC_1569 carminic acid 40.6 µM 1.68252542417469 0.0528737479436045 no 237 0.0462334995657032 329 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_680 0417-1641 114 µM 1.6790100917263 0.0532402083227316 no 238 0.0465750384917717 304 2835990
SGTC_3229 9132204 49.47 µM 1.67868807522301 0.0532738777662329 no 239 0.0466064255970547 234 17682924
SGTC_3045 9092950 49.47 µM 1.67820094316231 0.0533248434590454 no 240 0.0466539388536222 352 44120432
SGTC_1960 st011366 51.8 µM 1.67718212219652 0.0534315614867213 no 241 0.0467534369415997 275 3972846
SGTC_1450 4112-4260 37.6 µM 1.66229428776376 0.0550103945962967 no 242 0.0482268912905307 348 1633175
SGTC_233 rapamycin 362 pM 1.66018257933812 0.0552372931731992 no 243 0.0484388640570189 333 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2882 9058044 58.44 µM 1.65869043206526 0.0553980664455218 no 244 0.0485890941925908 315 18076804
SGTC_343 4130-2827 29.8 µM 1.65824170436449 0.0554464873706215 no 245 0.0486343451070271 359 1118244
SGTC_1620 st003704 16.5 µM 1.65415415593605 0.0558891030571827 no 246 0.049048097434242 303 2834414
SGTC_3158 9100007 49.47 µM 1.65397684089793 0.0559083663202672 no 247 0.0490661091632884 287 19297233
SGTC_1013 4112-3890 241 µM 1.65130474388571 0.0561992939308057 no 248 0.0493381820587662 367 705171
SGTC_2997 9067075 71.4286 µM 1.65080675543413 0.0562536447152484 no 249 0.0493890201462628 384 27209819
SGTC_2365 9042475 200 µM 1.64819472954747 0.0565394019497557 no 250 0.0496563590102652 365 6464479
SGTC_218 alverine citrate 93.75 µM 1.64599490046099 0.0567809508493023 no 251 0.0498824044626365 304 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_536 3852-0578 10.6 µM 1.64310998379226 0.0570989558115963 no 252 0.050180089791339 319 2869208
SGTC_1963 st076565 50.3 µM 1.64125683990164 0.0573039666687361 no 253 0.0503720556250117 338 4914280
SGTC_121 0557-0495 61.343 µM 1.63541410809125 0.0579541340665076 no 254 0.0509811334444231 516 3104427
SGTC_346 4513-0042 7.16 µM 1.63488635534398 0.0580131456889694 no 255 0.0510364366701602 384 2827372
SGTC_2804 7954240 19.48 µM 1.62530705006272 0.0590925012141814 no 256 0.0520485749935404 385 828705
SGTC_2556 citropten 84.59 µM 1.62433676661229 0.0592027014531652 no 257 0.0521519772371263 405 2775 A potential DNA crosslinker.
SGTC_573 3702-0553 84.7 µM 1.62410574014897 0.059228964094962 no 258 0.0521766215558031 346 1222756
SGTC_1489 4065-0444 182 µM 1.62350617710947 0.0592971638840082 no 259 0.052240621980426 330 2877968
SGTC_1612 st002233 45.4 µM 1.62048987265569 0.0596412004897784 no 260 0.0525635440291652 361 1035021
SGTC_3035 9091303 49.47 µM 1.61794912917536 0.059932207077346 no 261 0.0528367806145262 314 25237002
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.61737325258097 0.0599983200202957 no 262 0.0528988678870612 375 2333 A French combination drug.
SGTC_2113 5491891 107.031 µM 1.61365038788533 0.0604270988154588 no 263 0.0533016403950305 381 789979
SGTC_2451 5856223 45.7 µM 1.61343717773641 0.0604517275796906 no 264 0.0533247807484392 353 2179896
SGTC_3079 9117512 49.47 µM 1.61193425945528 0.0606255586219476 no 265 0.0534881230521712 287 7185044
SGTC_36 0335-0881 14.2 µM 1.60584082933123 0.0613343481902507 no 266 0.0541544435614917 458 23828853
SGTC_1479 0549-0158 134 µM 1.59884998966061 0.0621554807679522 no 267 0.054926969206503 392 5440202
SGTC_1930 st074634 34.3 µM 1.5981270691512 0.0622408807906044 no 268 0.05500735021873 393 684253 YOR116C RPO31
SGTC_1761 st044296 37 µM 1.58598825820755 0.0636885733188049 no 269 0.056370986573893 382 1826700
SGTC_2058 5236698 133 µM 1.57843035650637 0.0646030884340636 no 270 0.0572333879335123 388 766665
SGTC_1718 roemerine 11.9335 µM 1.57755708972103 0.0647094088001056 no 271 0.0573336984484399 452 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1904 st060225 78 µM 1.5766887898306 0.0648152591242533 no 272 0.0574335755335247 359 66595
SGTC_176 1486-1328 72.834 µM 1.57534915061037 0.0649788318440659 no 273 0.0575879373491007 428 22310231
SGTC_325 2810-4341 181 µM 1.57359453163521 0.065193558921706 no 274 0.0577906091388672 347 774970
SGTC_250 brefeldin a 552.239 µM 1.57052408887076 0.0655706383580509 no 275 0.0581466173730912 299 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_589 1227-0070 34.1 µM 1.56982285153579 0.065656993705578 no 276 0.058228164861432 370 2841384
SGTC_2003 4023581 200 µM 1.56954321835791 0.065691454302675 no 277 0.0582607086890097 387 16641307
SGTC_231 b-estradiol 524 µM 1.56417473082658 0.0663557619916539 no 278 0.0588882698834563 310 450 A steroid.
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.5580793238947 0.0671163131814631 no 279 0.0596072226759133 284 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1783 st039459 87.517 µM 1.55755236000561 0.0671823801171016 no 280 0.0596696996709225 441 729761
SGTC_2721 ifenprodil 61.44 µM 1.55710367416584 0.0672386727406927 no 281 0.0597229364320569 380 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.55239954521624 0.0678310554435722 no 282 0.0602833261079739 438 442882
SGTC_2026 5148700 152 µM 1.5504474160077 0.068078063845426 no 283 0.0605170826698034 390 79838
SGTC_322 k048-0136 19.3 µM 1.54952472248863 0.0681950562617574 no 284 0.0606278165934897 374 6823282
SGTC_2735 sertaconazole 140 nM 1.54915898998414 0.0682414720349897 no 285 0.0606717525739569 294 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2776 terbinafine 19.92 µM 1.54893737539599 0.0682696094039451 no 286 0.0606983875733398 411 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_978 1416-0512 87.4 µM 1.5484257515403 0.0683346020887238 no 287 0.060759912591271 446 6814003
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.54800223512651 0.0683884384050002 no 288 0.0608108791885826 389 803109
SGTC_560 2332-1943 155 µM 1.54750144994081 0.0684521391482153 no 289 0.0608711875547446 381 21177716
SGTC_1393 3470-5649 58.2 µM 1.54587168780595 0.0686597646388563 no 290 0.0610677797096983 315 4108395
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.54502640434913 0.0687676416337454 no 291 0.0611699383757394 670 16725076
SGTC_968 1309-0633 340 µM 1.54242350394688 0.0691006506154278 no 292 0.0614853568136981 384 3761976
SGTC_2344 7990960 76.95 µM 1.540737577778 0.0693170062927339 no 293 0.06169033359171 376 140813
SGTC_1288 0973-0013 65.5 µM 1.53551852500216 0.0699900784192331 no 294 0.0623282551137297 403 4315430
SGTC_3284 9108171 64.8615 µM 1.53526778774551 0.0700225407565071 no 295 0.0623590316011387 346 8687505
SGTC_1747 st037496 66.6 µM 1.53387197165388 0.0702034654149736 no 296 0.0625305762805578 448 723305
SGTC_2635 hydroquinidine 100 µM 1.53277219208556 0.0703462711147685 no 297 0.0626659972579848 402 442912 An experimental heart treatment.
SGTC_3273 9137859 49.47 µM 1.53089083995412 0.0705910812713098 no 298 0.0628981867431709 342 2377234
SGTC_1111 tnp00062 510.699 nM 1.52672515920038 0.0711354683215188 no 299 0.0634146842551213 381 676306
SGTC_300 r073-0011 5.04 µM 1.52376627785527 0.0715241002381084 no 300 0.0637835531386248 466 2735780
SGTC_545 4218-0007 221 µM 1.51944817396526 0.0720941792075 no 301 0.0643248619242278 388 2840508
SGTC_1768 st044301 37.178 µM 1.51857066110675 0.0722104537329641 no 302 0.0644353003698182 413 3931349
SGTC_2028 5153890 36.43 µM 1.51620237568286 0.0725249799311535 no 303 0.064734093771578 408 2830968 YPR165W RHO1
SGTC_1248 0469-0687 58.6 µM 1.51594273410777 0.0725595260272891 no 304 0.0647669166438318 424 4017482
SGTC_2588 indole-3-carbinol 100 µM 1.51300655304836 0.0729510714818561 no 305 0.0651389971573478 466 3712 Induces cell cycle arrest.
SGTC_1368 1852-0141 284 µM 1.51298550981297 0.0729538834635247 no 306 0.0651416697849802 412 2838987
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.51206507894549 0.0730769607048938 no 307 0.0652586537674917 370 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.51026628483547 0.0733179486551615 no 308 0.0654877455135854 404 6312947
SGTC_2777 climbazole 1.536 µM 1.50922611956169 0.0734575787581769 no 309 0.0656205037394857 452 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3329 9141233 27.5565 µM 1.50600981934558 0.0738906164014785 no 310 0.0660323264824559 384 4909101 YNL103W MET4
SGTC_774 k060-0086 136 µM 1.50364453526944 0.074210317401153 no 311 0.0663364587675991 485 5911235
SGTC_2923 7992654 58.14 µM 1.50182129147915 0.0744574743410011 no 312 0.0665716340297614 411 2985126
SGTC_192 3455-0609 60.9 µM 1.49745510682721 0.0750519034792753 no 313 0.0671374392720096 404 3769639
SGTC_2512 diallyl trisulfide 49.23 µM 1.49593805343155 0.0752592859855935 no 314 0.0673348993517767 352 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3167 9103034 49.47 µM 1.49286753350398 0.0756803652426288 no 315 0.0677359325772651 327 5127859
SGTC_677 0929-0063 136 µM 1.49200323404251 0.0757992150374631 no 316 0.0678491487614406 347 1539583
SGTC_1243 0416-0003 5.65 µM 1.48160722447497 0.0772399293040156 no 317 0.0692224178047861 444 2141977
SGTC_650 1328-0195 38 µM 1.47679085920181 0.0779144083595119 no 318 0.0698658537895255 453 2780821
SGTC_3005 9076496 71.4286 µM 1.4759798860258 0.078028414548764 no 319 0.0699746459843662 390 21368410
SGTC_1843 st055809 45.5 µM 1.47356666608127 0.0783684124207051 no 320 0.0702991509554754 413 16413835
SGTC_1160 4092-0570 10.5 µM 1.47231813325468 0.0785447582084778 no 321 0.0704674944140234 462 4994975
SGTC_2323 6148992 148.28 µM 1.46401926413646 0.0797245628781939 no 322 0.0715943424352766 389 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2944 9067346 25.62 µM 1.46391259407722 0.0797398143604979 no 323 0.0716089159213961 455 6473075
SGTC_482 fipronil 114 µM 1.46125819965481 0.0801200457747946 no 324 0.0719722982758009 323 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_235 0330-0087 5 mM 1.46108659435313 0.080144674637087 no 325 0.0719958393365756 484 46494818 YHR062C RPP1
SGTC_1037 k284-1091 78.7 µM 1.45927024642108 0.0804057085841424 no 326 0.0722453706085933 380 3334711
SGTC_2969 9091408 28.7 µM 1.45882323996773 0.0804700478921327 no 327 0.0723068822106479 448 4286311
SGTC_919 tnp00227 403.569 nM 1.45738751898829 0.0806769596593996 no 328 0.0725047201765035 492 1269246 A methoxyflavone. YNL221C POP1
SGTC_2461 5755302 26.15 µM 1.45655354211126 0.0807973342268977 no 329 0.0726198298794688 484 2788904
SGTC_2607 solasodine 47.35 µM 1.45624429161432 0.0808420052800388 no 330 0.0726625497509792 467 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3055 9094636 49.47 µM 1.4556249607179 0.0809315233259625 no 331 0.0727481619994748 411 25236176
SGTC_2658 polymyxin b sulfate 77.05 µM 1.45411675895375 0.0811498316636921 no 332 0.0729569689824258 466 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1293 1000-1278 195 µM 1.45162815625885 0.0815110216054257 no 333 0.0733025127208092 460 678847
SGTC_2390 9097792 176.6 µM 1.44830740025893 0.0819948747783643 no 334 0.0737655494784735 421 4497149
SGTC_2383 9036125 200 µM 1.44140201421958 0.0830079534222749 no 335 0.0747355707849326 388 79580
SGTC_1385 3091-4834 14.1 µM 1.44047325728444 0.0831449251116781 no 336 0.0748667753845027 418 4072814
SGTC_16 erodoxin 22.806 µM 1.43936033007457 0.083309281730593 no 337 0.0750242289015779 531 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_750 4073-0104 132 µM 1.43622475769207 0.0837736550785816 no 338 0.0754691981694996 357 22330957
SGTC_1662 st014054 52 µM 1.43571999712242 0.0838485906651762 no 339 0.0755410163275032 391 2838777
SGTC_748 act1.228 77.9 µM 1.43336780801424 0.084198455247673 no 340 0.0758763765735621 525 4421505 YNR035C ARC35
SGTC_1049 3226-0134 66 µM 1.4326418695091 0.0843066522987674 no 341 0.075980104913283 499 5702385
SGTC_2256 7954252 200 µM 1.43194740082289 0.0844102565721818 no 342 0.076079437591222 365 2972920
SGTC_2737 bleomycin 30.5 nM 1.43141537950112 0.0844896907471435 no 343 0.0761556016167101 523 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.4296941050843 0.0847470722227477 no 344 0.0764024164508398 443 5355888
SGTC_1471 k673-0312 37 µM 1.422747738594 0.0857917356504547 no 345 0.0774046481399849 450 24099884
SGTC_1227 3909-8010 46.6 µM 1.42100980541383 0.0860546045113196 no 346 0.0776569544418342 445 15982272
SGTC_460 trequinsin 123 µM 1.41870198508711 0.0864046017347531 no 347 0.0779929591214104 475 5537 A vasodilator.
SGTC_836 0330-0104 1.35 µM 1.41684508603261 0.086686985456072 no 348 0.0782641123047258 461 46494820
SGTC_1630 st005209 31.3 µM 1.41623586097031 0.0867797820825673 no 349 0.0783532298102494 508 3367314
SGTC_2090 5301565 104.445 µM 1.41592715045923 0.0868268329238551 no 350 0.078398417379652 531 2056344
SGTC_2701 st077767 14.721 µM 1.41560602143193 0.0868757967058181 no 351 0.0784454436765985 529 5721188
SGTC_261 5-fluorouridine 15.376 µM 1.41002880681897 0.0877294694901057 no 352 0.0792655885441049 470 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2732 terfenadine 20 µM 1.4092734400774 0.0878455687357679 no 353 0.0793771646282361 394 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1787 fluconazole 80 µM 1.4081697993413 0.088015403383634 no 354 0.079540398336922 543 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2110 5483698 200 µM 1.4039281820432 0.0886704070245021 no 355 0.0801701183083567 456 2848765 YHR062C RPP1
SGTC_3057 9095946 49.47 µM 1.39819136865534 0.0895620698823397 no 356 0.081027804009333 463 24540043
SGTC_619 1652-1634 108 µM 1.39363659635644 0.0902747454480178 no 357 0.0817136857222171 444 5400454
SGTC_695 3505-6186 243 µM 1.39179046387984 0.0905648023831588 no 358 0.0819929292577722 491 1819379
SGTC_3256 9138902 49.47 µM 1.39017060928145 0.0908198767883098 no 359 0.0822385380052839 429 17228773
SGTC_2484 5809818 12.04 µM 1.38148461428726 0.092196736913461 no 360 0.0835650026398585 481 2870548
SGTC_1215 3852-0577 11.2 µM 1.37906393357598 0.0925831901723723 no 361 0.0839375213322223 547 2884876
SGTC_24 0417-1663 219 µM 1.3785290309786 0.0926687469287117 no 362 0.0840200054924053 477 4329390
SGTC_951 1171-0579 82.7 µM 1.37783958920499 0.0927791082047199 no 363 0.0841264099780908 582 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3271 9137798 49.47 µM 1.37744874992363 0.0928417143203592 no 364 0.0841867747793159 417 6498326
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.36723164116812 0.0944894288550248 no 365 0.0857763552822052 385 279621
SGTC_2149 5554786 194.827 µM 1.36460977725492 0.0949157127213047 no 366 0.0861878650611208 547 745063 YPR165W RHO1
SGTC_2265 7929201 200 µM 1.36426870430048 0.0949712711067553 no 367 0.0862415058973051 505 1265108
SGTC_508 roscovitine 141 µM 1.36241540110483 0.0952735799727843 no 368 0.086533413011753 488 160355 A CDKinase inhibitor.
SGTC_1765 st044815 90.4 µM 1.35667175656964 0.0962149769840514 no 369 0.0874427652189596 507 645695
SGTC_2752 diclazuril 33.15 µM 1.35112829777202 0.0971300302612438 no 370 0.0883271690743275 686 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_884 0851-0618 334 µM 1.34865270955759 0.0975407298964935 no 371 0.0887242709255438 544 9642473
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.34838273116212 0.0975855961670526 no 372 0.0887676576448384 502 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3023 9089636 49.47 µM 1.34663444777189 0.0978765004224508 no 373 0.0890489969793713 523 17249241
SGTC_2818 7996756 12.99 µM 1.34390392278148 0.0983321147825017 no 374 0.0894897286800387 406 2241621
SGTC_2330 7979373 200 µM 1.3432952356331 0.0984338914700688 no 375 0.0895881971097876 533 1863007
SGTC_2782 7736369 71.43 µM 1.34204431139517 0.0986432967371844 no 376 0.089790814293913 539 2950836 YOL077C BRX1
SGTC_1864 st057645 30.4 µM 1.34197032696817 0.098655691968073 no 377 0.0898028085067489 470 688666
SGTC_338 4055-0136 114 µM 1.34088223441714 0.0988381209252292 no 378 0.0899793455554576 519 2900563
SGTC_1162 k048-0130 20.1 µM 1.34047055705839 0.0989072068321291 no 379 0.0900462051492923 515 6797406
SGTC_222 nsc-310342 10.666 µM 1.33743045406845 0.0994184777739076 no 380 0.0905410846084266 377 432556
SGTC_2877 9040724 71.43 µM 1.33567703320142 0.0997142373031099 no 381 0.0908274296585835 500 6463895
SGTC_1829 berberine 14.4 µM 1.33494144457731 0.0998385044634164 no 382 0.0909477559479159 507 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1645 Cervolide 78 µM 1.33072859412644 0.100552384826565 no 383 0.0916391654086664 485 23173 A fragrance.
SGTC_838 0109-0203 71.4 µM 1.32737424031747 0.101123447737607 no 384 0.0921924582528035 531 759422
SGTC_1980 st071811 45.7 µM 1.32699206011172 0.101188661808055 no 385 0.0922556545780419 507 4974850
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.3246747269635 0.101584740882486 no 386 0.0926395295251767 501 688803
SGTC_2685 mycophenolic acid 18.85 µM 1.32340149296883 0.101802842286985 no 387 0.0928509477869388 469 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_523 1934-0222 13.7 µM 1.32283357860695 0.101900234272212 no 388 0.0929453639338338 537 1361595
SGTC_2314 7727897 200 µM 1.32054626733722 0.102293173256367 no 389 0.0933263496149584 507 900724
SGTC_3205 9113483 49.47 µM 1.31752912823819 0.102813173933914 no 390 0.0938306619893333 575 17018033
SGTC_1025 k007-0731 70 µM 1.31629330567746 0.103026720216422 no 391 0.0940378084339974 498 6256118
SGTC_3172 9105863 49.47 µM 1.31550042260094 0.103163897491577 no 392 0.0941708877050618 432 2348785
SGTC_1441 4106-0040 13 µM 1.31426597816386 0.103377733547832 no 393 0.094378356075636 514 2904180
SGTC_1818 st052136 56.3 µM 1.31295260686266 0.103605594749792 no 394 0.094599459252233 532 674169
SGTC_2704 st078022 71.1 µM 1.31161505621497 0.103838025255788 no 395 0.0948250251709851 523 54697681
SGTC_1387 3342-1166 1.8 µM 1.31127190051875 0.103897717450152 no 396 0.0948829591309694 456 3418228
SGTC_1806 st050005 60.3 µM 1.31100599700057 0.103943988680335 no 397 0.0949278687644918 542 5194765
SGTC_1218 1348-1416 30.7 µM 1.31069000800827 0.103998994969514 no 398 0.0949812579178901 548 6787668
SGTC_1516 st013856 110 µM 1.30861200630976 0.104361252324123 no 399 0.0953329059280766 504 5281404 A mutagen and neurotoxin.
SGTC_499 genistein 192 µM 1.30746408407996 0.10456176089831 no 400 0.0955275725710604 480 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2405 ticlatone 3.52 µM 1.30316328359289 0.105315466757983 no 401 0.0962595111096661 522 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2319 6033012 152.6 µM 1.3021262757605 0.105497786776966 no 402 0.0964366111102612 479 847246
SGTC_887 0885-0007 9.62 µM 1.30146709147466 0.105613798907219 no 403 0.0965493108731026 579 5719458
SGTC_1161 k007-0610 110 µM 1.29987194322323 0.105894916224176 no 404 0.0968224313218157 659 5843850
SGTC_2429 5902844 64.44 µM 1.29752860801259 0.106308868700274 no 405 0.0972246841908098 569 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_289 k017-0060 526 µM 1.29280255058408 0.1071472839677 no 406 0.0980396790191698 501 5512909
SGTC_3179 9107801 49.47 µM 1.2927888944465 0.107149713492471 no 407 0.0980420412114903 539 4818259
SGTC_445 e6 berbamine 66 µM 1.29067311271246 0.107526606241199 no 408 0.0984085258975193 687 6610268 A calcium/calmodulin antagonist.
SGTC_3148 9097893 49.47 µM 1.2906647743141 0.107528093481376 no 409 0.0984099722132693 524 17174100
SGTC_2572 astragaloside iv 100 µM 1.29022572974856 0.107606422592042 no 410 0.0984861475634455 541 45006101 An anti-inflammatory agent.
SGTC_3115 9123671 49.47 µM 1.28732203414539 0.10812550070926 no 411 0.0989910333256352 550 3286988
SGTC_1848 st056003 16.4 µM 1.28548157867374 0.108455441039958 no 412 0.0993120249769277 588 146492
SGTC_3017 9080681 49.47 µM 1.28057270620633 0.109339000641485 no 413 0.100171895949265 534 16451914
SGTC_2689 tacrolimus 100 µM 1.27987697883915 0.109464643426311 no 414 0.100294202612723 537 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_318 1488-0629 67.2 µM 1.27925957714197 0.109576228031729 no 415 0.100402831117597 520 3662576
SGTC_2656 pseudo-anisatin 100 µM 1.27874985417691 0.109668413113224 no 416 0.100492578809916 506 6708809 A neurotoxin.
SGTC_191 3914-0123 66.505 µM 1.27800402862058 0.109803398444594 no 417 0.100624002898723 417 3144412
SGTC_3078 9116413 49.47 µM 1.27756389580781 0.109883113047932 no 418 0.100701618780896 509 17177322
SGTC_2264 7948757 110.76 µM 1.27600869437832 0.110165115803229 no 419 0.100976222836267 535 2971411
SGTC_3319 9138450 16.7555 µM 1.27591797765545 0.110181581363914 no 420 0.100992257645968 523 2029690
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.27587943535162 0.110188577528358 no 421 0.10099907082719 613 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_94 0334-0113 514.748 µM 1.27226971904 0.110845223008353 no 422 0.101638651814909 551 6795178
SGTC_189 3970-0742 2.116 µM 1.26999368064967 0.111260696884586 no 423 0.102043440579891 540 2891807
SGTC_1602 st001878 87.6 µM 1.26961291594187 0.111330311364779 no 424 0.102111273178296 555 595405 YLR310C CDC25
SGTC_298 1391-0729 10 µM 1.26802453219824 0.111621048828511 no 425 0.102394594968181 522 3237558
SGTC_3181 9108277 49.47 µM 1.26699547065356 0.111809697794074 no 426 0.102578454717672 542 17097298
SGTC_1061 3448-9325 110 µM 1.26466304553774 0.112238125046775 no 427 0.102996071229465 535 723482
SGTC_2705 st078069 42.8 µM 1.26157827818926 0.112806545031516 no 428 0.103550288236444 536 1530061
SGTC_1958 st076513 41.9 µM 1.25985003838874 0.113125898961683 no 429 0.103861732427076 577 732122 YGL099W LSG1
SGTC_3228 9131799 49.47 µM 1.25944212549036 0.113201369425435 no 430 0.103935340964177 558 17015818
SGTC_2213 7173844 200 µM 1.25877071883446 0.113325668692864 no 431 0.104056579743586 600 892728
SGTC_719 2810-4230 27.3 µM 1.25779544078265 0.113506397835164 no 432 0.104232872490353 535 721079
SGTC_2231 micatex 6.853 µM 1.25635779762045 0.113773182651488 no 433 0.104493137677635 530 20737 An antifungal of unknown mechanism.
SGTC_2145 5634607 200 µM 1.25288674711859 0.11441915016116 no 434 0.105123462827558 507 308662
SGTC_1488 4013-0813 75.9 µM 1.25149199586848 0.114679449373068 no 435 0.105377516045573 520 2910057
SGTC_3276 9139060 49.47 µM 1.25023984398244 0.114913494311398 no 436 0.105605972949412 524 4870619
SGTC_3323 9138564 53.9225 µM 1.25022952218213 0.114915425013022 no 437 0.105607857663777 637 43912313 YNL103W MET4
SGTC_1340 1486-1359 257 µM 1.2492212995594 0.11510412513243 no 438 0.105792071819281 597 4309068
SGTC_2798 7813637 45.45 µM 1.24683808124576 0.115551046700098 no 439 0.106228437073 582 956368
SGTC_2947 9072639 7.68 µM 1.24566767543153 0.115770982093351 no 440 0.106443212766485 626 16488146
SGTC_162 k030-0015 37.8 µM 1.24341896609648 0.116194379570627 no 441 0.106856742428356 588 1809920 YMR134W ERG29
SGTC_2883 9059145 45.46 µM 1.24201626706641 0.116459042156816 no 442 0.107115280125173 548 16476510
SGTC_1521 st012942 49.4 µM 1.24049243626608 0.116747044281938 no 443 0.107396655053083 639 24207259
SGTC_738 1315-0003 72.4 µM 1.24016999069064 0.116808050767265 no 444 0.107456262771733 624 6251474
SGTC_681 1642-0006 26.6 µM 1.23927013765503 0.116978421877729 no 445 0.107622736918447 550 4446530
SGTC_795 0685-0265 78 µM 1.23742946822884 0.117327468134394 no 446 0.107963842150444 595 302754
SGTC_2766 oltipraz 83.91 µM 1.23554775544015 0.117685059265882 no 447 0.108313357402407 578 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_954 1189-0853 2.85 µM 1.23546945888254 0.117699955043536 no 448 0.108327918076594 613 2828194
SGTC_3159 9100096 49.47 µM 1.23460813978948 0.11786390752102 no 449 0.108488189072734 574 25236875
SGTC_3289 9119912 71.43 µM 1.23398462578981 0.117982694476758 no 450 0.108604316594541 578 17014829
SGTC_1361 1608-0041 5.61 µM 1.23247631639437 0.118270395804945 no 451 0.108885604161406 605 X1361
SGTC_266 formosanin C 406 nM 1.22918371917678 0.118900162152551 no 452 0.109501465841628 618 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.22853470514698 0.119024576250948 no 453 0.109623154807361 584 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2416 tofa 880 nM 1.22659306071105 0.119397332589626 no 454 0.109987789329775 564 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2822 7994718 71.43 µM 1.22618432469878 0.119475906449778 no 455 0.110064659381663 521 1018011
SGTC_3307 9126885 69.2785 µM 1.22577791468379 0.119554069332168 no 456 0.11014113019603 623 24824909
SGTC_725 1497-0963 19 µM 1.21770445035318 0.121114280169413 no 457 0.11166815263583 623 3549977
SGTC_1191 1487-1166 10.6 µM 1.2168842897246 0.121273575362573 no 458 0.111824121889852 708 3955771
SGTC_1402 3909-7673 35.9 µM 1.2160980325184 0.121426423957222 no 459 0.111973789975483 588 5328014
SGTC_2863 9028737 58.44 µM 1.21591667781383 0.121461698570657 no 460 0.112008332091404 564 6460917
SGTC_1404 3909-7820 48.3 µM 1.2139870439101 0.121837470465286 no 461 0.112376335832917 599 23741373
SGTC_467 ro 31-8220 72.8 µM 1.21060973482635 0.122497122988653 no 462 0.113022505776604 641 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1866 st057638 64 µM 1.21053349839865 0.122512042276649 no 463 0.11303712239386 600 688802
SGTC_1416 3966-0321 25.3 µM 1.21045476087089 0.122527452362354 no 464 0.11305221995679 627 582530 YLR208W SEC13
SGTC_565 1418-0001 44.5 µM 1.20387754831061 0.123819513757443 no 465 0.114318455375411 663 2862145
SGTC_2239 6685329 187.64 µM 1.20165607614677 0.124258058191345 no 466 0.114748402806653 617 805680
SGTC_510 ag-490 170 µM 1.19831288691658 0.124920088465345 no 467 0.1153976157569 665 5328779
SGTC_1280 0880-0253 10.1 µM 1.19805842063137 0.124970579517386 no 468 0.115447137181202 641 6836607
SGTC_1550 gossypolone 36.6 µM 1.19471396698694 0.125635509243739 no 469 0.116099401795458 646 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3120 9124077 49.47 µM 1.19305587105184 0.12596607832292 no 470 0.116423746259467 642 18774327 YGL155W CDC43
SGTC_1652 st011932 78 µM 1.18976017603705 0.126624929727457 no 471 0.117070333073409 609 1551076
SGTC_758 0868-0029 16 µM 1.18774924111569 0.127028118235118 no 472 0.117466108792842 632 762687
SGTC_2858 9025781 8.96 µM 1.18715589405722 0.127147253677944 no 473 0.117583067291468 749 4894980 YPL153C RAD53
SGTC_2938 9059746 27.26 µM 1.18503268918796 0.127574199020426 no 474 0.118002261226873 606 6471769
SGTC_1042 0350-0096 82 µM 1.18334220861275 0.127914841842482 no 475 0.118336775546986 610 3122515
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.17885318467099 0.128822474964551 no 476 0.119228321058181 669 23665772 A membrane-active detergent.
SGTC_1073 triclabendazole 3.09 µM 1.17662486887034 0.129274672156785 no 477 0.119672633615214 699 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1579 chlormadinone acetate 49.4 µM 1.17588141696206 0.129425787018641 no 478 0.119821132853442 661 45114258 A steroidal progestin.
SGTC_2206 7254556 146.969 µM 1.17493377600562 0.129618582956941 no 479 0.120010605688708 593 4398905
SGTC_1096 rimcazole 32.2 µM 1.17451212695905 0.129704430654701 no 480 0.120094978717637 602 18528119 A dopamine reuptake inhibitor.
SGTC_1746 st038117 42 µM 1.16631092849432 0.131382028378025 no 481 0.121744378129813 661 2898218
SGTC_821 1114-0266 29.2 µM 1.16306887214353 0.132049321675794 no 482 0.12240078014194 638 3123235
SGTC_3204 9114183 49.47 µM 1.16256197978768 0.132153863236151 no 483 0.122503632061366 614 17027248
SGTC_2996 9066192 71.4286 µM 1.16125809656624 0.132423038449523 no 484 0.122768477447602 630 6472854
SGTC_257 daunorubicin 18.5 µM 1.16115384135265 0.132444577321659 no 485 0.122789671141625 631 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_42 0133-0086 60.653 µM 1.16009472814051 0.132663524358765 no 486 0.123005120171764 582 162923 Model of phenazepam hydroxylation.
SGTC_1486 3970-0793 4.53 µM 1.15864835157895 0.132962931622514 no 487 0.12329977573676 661 2844330
SGTC_1109 tnp00067 928.257 nM 1.15717285643405 0.133268845589442 no 488 0.123600872570014 662 676295
SGTC_1604 st002052 72.4 µM 1.15607813917547 0.13349612569624 no 489 0.123824598462917 658 6254834 YHR062C RPP1
SGTC_1793 st048256 72.231 µM 1.15562168006242 0.133590972322239 no 490 0.12391796808928 649 672022
SGTC_2305 7443522 69.23 µM 1.15536552665788 0.133644218163249 no 491 0.12397038636142 693 5415886
SGTC_1713 st033146 12.748 µM 1.15506168141418 0.133707396482001 no 492 0.124032584230352 669 674619
SGTC_1292 0kpi-0043 232 µM 1.15359795914572 0.134012034872536 no 493 0.124332517734927 627 3333905
SGTC_1770 st043884 66.3 µM 1.15214217639213 0.134315493552037 no 494 0.124631327104229 662 670149
SGTC_2043 5101342 149 µM 1.15054686152219 0.134648579297512 no 495 0.124959352426356 654 678451
SGTC_3347 9188721 44.724 µM 1.15052849660908 0.134652417004856 no 496 0.124963132089686 623 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_793 0488-0545 106 µM 1.14524035272162 0.135760601917228 no 497 0.126054803387926 676 292548
SGTC_3048 9093155 49.47 µM 1.14514181710049 0.13578131017842 no 498 0.126075207741224 588 25236002
SGTC_326 k292-0812 17.5 µM 1.14467039304523 0.135880414662976 no 499 0.126172860166513 645 3579357
SGTC_3239 9133757 49.47 µM 1.14394915059432 0.136032132718186 no 500 0.126322362858258 670 17036923
SGTC_2838 9002687 71.43 µM 1.14194145034758 0.13645507609354 no 501 0.126739178796171 611 6457060
SGTC_1379 2144-0755 36.5 µM 1.13876937885053 0.137125138188585 no 502 0.127399678370501 723 5392327
SGTC_3222 9128301 49.47 µM 1.13617484641627 0.137674870635957 no 503 0.127941697744179 673 4911358
SGTC_2072 5231554 129 µM 1.13478002401036 0.137971027987881 no 504 0.128233749013249 688 789545
SGTC_714 4296-0578 26.1 µM 1.13169159538446 0.138628327724935 no 505 0.128882058110661 631 1589775
SGTC_1107 amlodipine 47 µM 1.13157861590155 0.138652413142525 no 506 0.128905817283859 680 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3113 9123498 49.47 µM 1.12969745104396 0.139053866292881 no 507 0.129301865830203 693 8897275
SGTC_2734 clemastine 41.6 µM 1.12927974006885 0.139143115852666 no 508 0.129389922358154 548 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2712 st079126 47.7 µM 1.12741445234566 0.139542135331129 no 509 0.12978364571275 627 3152970
SGTC_1331 1472-0049 76.2 µM 1.1267033052136 0.139694467537556 no 510 0.129933972267515 651 24051409
SGTC_554 4483-2211 187 µM 1.12647552232774 0.139743283968549 no 511 0.129982147861021 673 747107
SGTC_2360 9040895 200 µM 1.12307032533146 0.140474438592346 no 512 0.130703813986392 617 4914414
SGTC_245 methotrexate 289.6 µM 1.12130522841899 0.140854455648998 no 513 0.131078980390919 737 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3312 9133330 71.43 µM 1.12098508979043 0.140923454639444 no 514 0.131147104580048 735 17617324
SGTC_591 4299-0174 154 µM 1.1198469865435 0.141168933913956 no 515 0.131389486283008 671 5509088
SGTC_348 k064-0012 10.7 µM 1.11854840478053 0.141449380992854 no 516 0.131666422645064 643 5066323
SGTC_2000 st075254 36.4 µM 1.11747045716258 0.141682465609583 no 517 0.131896612193563 651 17234175
SGTC_636 0kpi-0074 126 µM 1.11612965115951 0.1419727509769 no 518 0.132183320834512 660 616434
SGTC_622 1348-1566 26.3 µM 1.11608561510698 0.141982291635156 no 519 0.13219274448008 743 7340407
SGTC_128 0906-2981 13.371 µM 1.10670243380746 0.144025114143545 no 520 0.13421130138793 641 6740226
SGTC_2887 9044784 58.44 µM 1.10634660366969 0.144102970449052 no 521 0.134288263764662 757 6465546
SGTC_868 0527-0199 213 µM 1.10388878137625 0.144641521540482 no 522 0.134820692977775 725 2849450
SGTC_576 1073-0113 22.7 µM 1.10328842913895 0.144773274794293 no 523 0.134950964917595 888 5439563
SGTC_1269 0831-0796 3.05 µM 1.1028033066612 0.144879798758517 no 524 0.135056295916891 702 927758
SGTC_1001 4048-4355 44.4 µM 1.1002267368073 0.145446450402068 no 525 0.135616671999038 701 21824233
SGTC_2417 cerulenin 830 nM 1.10020325407259 0.145451621683466 no 526 0.13562178655409 674 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2824 7998404 51.95 µM 1.099172510641 0.145678730052123 no 527 0.135846413353515 659 837851
SGTC_1362 1611-0397 101 µM 1.09811278074849 0.145912473562459 no 528 0.136077622565738 714 27816
SGTC_2296 7971656 126.45 µM 1.09811010738794 0.145913063541307 no 529 0.13607820617325 690 666570
SGTC_2228 7354201 200 µM 1.09720764964141 0.146112316833961 no 530 0.13627531496877 701 753451
SGTC_447 ml7 120 µM 1.09709554804369 0.146137080457924 no 531 0.136299813085198 721 4216 Selective myosin light chain kinase inhibitor.
SGTC_1297 1068-0111 14.1 µM 1.09504064327789 0.146591515391862 no 532 0.13674941549131 692 767057
SGTC_2984 9022109 38.96 µM 1.09394485798509 0.146834231742217 no 533 0.136989581607258 678 6459207
SGTC_2376 9072922 81.32 µM 1.0936324978295 0.146903468838443 no 534 0.137058095154696 720 17087968
SGTC_708 3448-5400 146 µM 1.09295956885662 0.147052703253863 no 535 0.137205775948843 724 3462195
SGTC_3255 9139072 49.47 µM 1.0927700254262 0.147094756349427 no 536 0.137247392706615 705 17646060
SGTC_1455 4262-0120 131 µM 1.09267412831405 0.147116035655112 no 537 0.137268451465371 744 1529587
SGTC_1824 st053723 68.6 µM 1.09030756558378 0.147641823373816 no 538 0.137788841831261 706 675225
SGTC_2690 usnic acid 100 µM 1.0866498213413 0.14845695070221 no 539 0.138595798962681 789 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_316 k060-0003 58.6 µM 1.08635063402891 0.148523757412416 no 540 0.138661946650422 703 6152314
SGTC_1296 1068-0102 11.9 µM 1.08568242608036 0.148673036764794 no 541 0.138809759204372 725 767053
SGTC_2240 6690706 185.951 µM 1.08446253613044 0.148945821884288 no 542 0.139079884595247 616 805876
SGTC_1213 1315-0166 115 µM 1.08380138350503 0.149093804863607 no 543 0.139226435835602 610 768401
SGTC_2470 5664817 21.68 µM 1.08276499166977 0.149325973600233 no 544 0.139456374089823 727 2859561
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.08235390273331 0.149418131074847 no 545 0.139547651521752 676 364106
SGTC_3253 9135987 49.47 µM 1.08150541429197 0.149608464324952 no 546 0.139736176788884 658 4182430
SGTC_3314 9135860 59.4275 µM 1.08140228113916 0.149631610215581 no 547 0.139759103694842 750 25252478
SGTC_1474 0330-0125 5.35 µM 1.07936775259828 0.150088702362726 no 548 0.140211910247905 733 X1474
SGTC_1444 4112-3581 28 µM 1.07857679606183 0.1502666555059 no 549 0.140388214975619 747 2877249
SGTC_3053 9095903 49.47 µM 1.0769561857737 0.150631707111734 no 550 0.140749920082641 732 17174018
SGTC_1828 st055811 49 µM 1.07647799431775 0.150739535185546 no 551 0.140856768675256 697 5877589
SGTC_2726 cimetidine 79.27 µM 1.07206141415803 0.151737865150733 no 552 0.141846224232185 644 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1342 1486-1464 234 µM 1.06913352977085 0.152402104751464 no 553 0.142504752491254 761 3253938
SGTC_2446 5162541 200 µM 1.06871596537256 0.152496993232515 no 554 0.142598837638089 693 1549321
SGTC_2332 7982454 138.89 µM 1.06667045904776 0.152962386017467 no 555 0.143060335639324 751 2981748
SGTC_962 1254-0300 21.5 µM 1.06272035822843 0.153863773694561 no 556 0.14395439286013 740 7340576
SGTC_514 4466-0038 2.65 nM 1.06230683566177 0.153958339755801 no 557 0.144048206098832 801 5722064
SGTC_1696 st025591 34.7925 µM 1.06186451293745 0.154059534518618 no 558 0.144148598672717 760 2787147
SGTC_806 3966-4455 5.86 µM 1.05958865430113 0.15458090187551 no 559 0.144665888718374 659 714982
SGTC_2855 9016525 58.44 µM 1.05818528865778 0.154902973861945 no 560 0.144985488435585 741 43811474
SGTC_2237 6667747 47.222 µM 1.0574620119183 0.155069138610573 no 561 0.145150391522002 713 729940 YDL015C TSC13
SGTC_1571 st070080 73.4 µM 1.05685441467972 0.155208818216241 no 562 0.14528901783962 741 4315245
SGTC_252 miconazole 1.30953 nM 1.05474142890706 0.155695215739566 no 563 0.145771799328184 725 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2774 tamoxifen 10.92 µM 1.05437793673617 0.155778990836758 no 564 0.145854959719097 745 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_999 SEC7.066 22.7 µM 1.05125714559592 0.156499471496698 no 565 0.146570251784632 798 740511 YDR170C SEC7
SGTC_1442 4112-3290 3 µM 1.05108670236023 0.156538883919215 no 566 0.146609385429235 782 704353
SGTC_2121 5257820 149.641 µM 1.04898510832425 0.157025382794354 no 567 0.14709248616035 816 791256
SGTC_1526 st051518 75 µM 1.04770598366115 0.157321974244739 no 568 0.147387044932092 685 673993
SGTC_3202 9113761 49.47 µM 1.04760265081528 0.157345950164168 no 569 0.147410857820743 819 4798415
SGTC_2508 celastrol 40.54 µM 1.04694299773288 0.157499063517266 no 570 0.147562934573905 703 122724 Celastrol is a natural product and antioxidant.
SGTC_3337 9144342 33.5465 µM 1.04475741595244 0.158007062534633 no 571 0.148067550446266 776 17682949
SGTC_630 4356-0227 183 µM 1.04447988412201 0.158071646682047 no 572 0.148131710643392 724 779312
SGTC_990 3985-0011 41.3 µM 1.0407610293683 0.158938729128802 no 573 0.148993235446802 695 5399565 YGL099W LSG1
SGTC_1914 st062367 72.6 µM 1.0393306800738 0.159273055551152 no 574 0.149325485460597 716 978205
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.03882924999166 0.159390367566086 no 575 0.149442077623831 796 165521
SGTC_1153 4055-0057 267 µM 1.03470258291288 0.160357969516117 no 576 0.150403914717098 779 882706
SGTC_169 k015-0017 16.025 µM 1.03372171650183 0.160588522018097 no 577 0.150633138869963 688 1840002
SGTC_1128 3448-9350 235 µM 1.03363912927245 0.160607944011607 no 578 0.150652449754819 691 619386
SGTC_1053 3366-3204 134 µM 1.0322503006343 0.160934783909867 no 579 0.15097743833525 745 3632071 YPR165W RHO1
SGTC_2511 berberine 10.47 µM 1.03028768561276 0.161397395526141 no 580 0.15143748901949 770 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1253 0550-0034 176 µM 1.02906272830436 0.161686571593115 no 581 0.151725099546099 707 5969915
SGTC_2676 harmalol 100 µM 1.02844256330266 0.16183310282684 no 582 0.151870847828268 806 5459187 A monoamine oxidase inhibitor
SGTC_3171 9103192 49.47 µM 1.02656674672869 0.16227684318005 no 583 0.152312259491457 773 13018434
SGTC_119 0121-0043 24.815 µM 1.02639975065587 0.162316385881858 no 584 0.152351597761323 928 1092378
SGTC_885 0865-0106 16.8 µM 1.02229479329984 0.163290363229805 no 585 0.153320698403244 767 2793380
SGTC_1842 st055362 61.2 µM 1.02226473896614 0.163297508151722 no 586 0.153327808674352 811 676032
SGTC_452 diindolylmethane 8 µM 1.01795014186882 0.164325339895259 no 587 0.154350825414789 716 3071 Inhibits expression of several cancer promoting factors.
SGTC_790 1575-0012 79.1 µM 1.01782709167947 0.164354714538575 no 588 0.15438006738942 813 378741 YLR208W SEC13
SGTC_3126 9127922 49.47 µM 1.01449894176862 0.165150504358984 no 589 0.15517236705811 756 45595682
SGTC_3321 9137793 26.8275 µM 1.01375869093855 0.165327843325967 no 590 0.155348955515827 789 4904192
SGTC_2465 5809242 33.21 µM 1.00680242870957 0.167000344096391 no 591 0.157014863645062 812 2731748
SGTC_2015 5119600 184 µM 1.00653170050019 0.167065655373294 no 592 0.157079935204421 809 2828786
SGTC_2251 lansoprazole 556 µM 1.00624178441974 0.167135613848986 no 593 0.157149638376868 647 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2394 5221648 200 µM 1.00286687015512 0.167951390104933 no 594 0.157962549653535 887 788586
SGTC_2220 6782180 200 µM 1.0028434755564 0.167957053921465 no 595 0.157968194298995 706 833803
SGTC_1495 4469-0029 237 µM 1.00089958803127 0.168428097254704 no 596 0.158437677872197 893 793680
SGTC_2834 9001755 58.44 µM 1.00021293355647 0.168594690388104 no 597 0.158603735730084 728 2989575
SGTC_1614 st002383 48.6 µM 0.996881785471506 0.169404381855493 no 598 0.159410946930572 804 1947235
SGTC_3156 9099931 49.47 µM 0.99553809791571 0.169731692863353 no 599 0.159737312249106 857 18111053
SGTC_281 1672-3440 14.9 µM 0.995248183095426 0.169802366840989 no 600 0.159807786321263 866 6833000
SGTC_3264 9137442 49.47 µM 0.994606975721287 0.169958744164065 no 601 0.159963726730732 764 17015726
SGTC_1019 4262-0212 3.4 µM 0.994256128612424 0.170044347640604 no 602 0.160049094186831 874 4677213
SGTC_852 0418-0143 439 µM 0.993884166272089 0.17013513321434 no 603 0.160139631887977 886 5369229
SGTC_2697 mebhydrolin 72.4 µM 0.993357061673195 0.170263837846509 no 604 0.160267989410251 837 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2079 5212404 121 µM 0.992422915756236 0.170492084101612 no 605 0.160495632465596 827 758462
SGTC_3030 9087619 49.47 µM 0.99163570875666 0.170684579822783 no 606 0.160687631746289 809 25236973
SGTC_2640 pentamidine 10.38 µM 0.991567133448945 0.170701355127141 no 607 0.160704364319339 873 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2384 9036245 200 µM 0.986718073955499 0.171890236411287 no 608 0.161890433544738 836 6462766
SGTC_1606 st000094 49.2 µM 0.985693416732889 0.172142134579917 no 609 0.162141790484119 873 1242210
SGTC_71 0417-1750 47.813 µM 0.984119347201384 0.172529557053808 no 610 0.162528417628005 860 6811472
SGTC_1223 0764-0573 147 µM 0.983829161221611 0.172601040584146 no 611 0.162599759315021 840 1609797
SGTC_1766 st045414 44.774 µM 0.983781269944108 0.17261283979081 no 612 0.162611535255476 877 253960
SGTC_2215 7188065 200 µM 0.982203441600886 0.173001864589126 no 613 0.162999816211795 793 940217
SGTC_22 0964-0034 14.468 µM 0.981965143672717 0.173060667151888 no 614 0.163058510262899 853 138402
SGTC_337 1315-0038 354 µM 0.979704706755255 0.173619087200878 no 615 0.1636159510484 819 1626437
SGTC_1186 1319-0216 26 µM 0.977206103382976 0.17423767656073 no 616 0.164233563506016 874 4565136
SGTC_1877 wortmannin 25 µM 0.976426581632732 0.17443095220695 no 617 0.164426557095465 860 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2970 9090938 41.86 µM 0.975616757162876 0.174631885322831 no 618 0.164627208648406 886 17217104
SGTC_1322 1348-1070 12 µM 0.974264641086933 0.174967698876946 no 619 0.164962578141184 811 6758089
SGTC_1493 4348-0038 111 µM 0.972806257667018 0.175330364142998 no 620 0.165324801009671 886 800424
SGTC_1860 st056228 74.6 µM 0.971909058805346 0.175553712788821 no 621 0.16554789636693 799 688679
SGTC_3316 9136639 10.545 µM 0.971247233879188 0.175718582967764 no 622 0.1657125889293 829 4903665
SGTC_380 3970-0968 6 µM 0.970408998602053 0.175927540272797 no 623 0.16592133252226 790 2891601
SGTC_730 1436-0052 41.2 µM 0.970321432215863 0.175949378106132 no 624 0.165943148755706 805 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_620 0109-0052 432 µM 0.969770232654183 0.176086878982578 no 625 0.166080516821095 853 493037
SGTC_3263 9137018 49.47 µM 0.964213707971805 0.177476793142341 no 626 0.16746939659429 786 43844957
SGTC_474 dl-dihydrosphingosine 5 µM 0.963741065746268 0.177595339044661 no 627 0.167587880125409 829 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_120 rhodamine 6G 52.259 µM 0.963182625850148 0.177735468700012 no 628 0.167727941273287 981 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1524 corynanthine 62.1 µM 0.962994127177745 0.177782784526652 no 629 0.167775235244085 824 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_296 1222-0039 74.9 µM 0.96272859293983 0.177849450846642 no 630 0.167841871862731 788 5984176
SGTC_1956 st077085 54 µM 0.962487812424447 0.17790991600617 no 631 0.167902311188663 863 24208685
SGTC_1056 3448-1962 115 µM 0.958827706718889 0.178830643084809 no 632 0.168822774429074 801 715507
SGTC_2343 7990716 14.84 µM 0.957054304539234 0.179277832460168 no 633 0.169269923077837 853 6456862
SGTC_1522 st012842 45.6 µM 0.957028058896645 0.179284455960396 no 634 0.169276546402996 756 3491067 YOR116C RPO31
SGTC_1790 st045711 43.5 µM 0.955960179509492 0.179554082601837 no 635 0.169546176509141 831 585119
SGTC_723 4182-0001 115 µM 0.954488677141105 0.179926036474051 no 636 0.169918169042271 801 744821 YLR208W SEC13
SGTC_3258 9138477 49.47 µM 0.952854431786452 0.180339693827146 no 637 0.170331915414994 853 4970355
SGTC_768 0384-0033 77.3 µM 0.951274893847517 0.1807400703552 no 638 0.170732424133575 854 3965305 YMR134W ERG29
SGTC_823 0417-1665 178 µM 0.947517845845194 0.181694632653011 no 639 0.171687483495374 870 3429856
SGTC_358 0075-0058 9.45 µM 0.945724260290941 0.182151443600653 no 640 0.172144622605018 925 1069125
SGTC_2754 granisetron 64.02 µM 0.945122595865586 0.182304843065197 no 641 0.172298145328676 842 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_601 0986-0029 62.9 µM 0.942381116170163 0.18300482808907 no 642 0.172998775894677 883 24747981
SGTC_1337 1486-1011 40.3 µM 0.940461622063317 0.183495931395277 no 643 0.173490413217783 874 X1337
SGTC_2696 st077691 74.316 µM 0.940083843007339 0.183592682970128 no 644 0.173587277861371 773 757133
SGTC_786 4544-0069 423 µM 0.939012797462253 0.183867157209234 no 645 0.173862086922533 891 748821 YLR208W SEC13
SGTC_1923 st058458 19.1 µM 0.938941989933611 0.183885311884458 no 646 0.17388026447634 923 3534982
SGTC_1897 st060201 15 µM 0.938350282802338 0.184037066099493 no 647 0.174032213483019 801 611878
SGTC_1721 st082152 9.2685 µM 0.935518710663131 0.184764353889377 no 648 0.174760522668244 821 5296051
SGTC_1682 st012968 530 nM 0.93371959044583 0.185227383873806 no 649 0.175224278425159 778 24207270
SGTC_553 k007-0256 45.7 µM 0.932577464855999 0.185521700249863 no 650 0.175519086552871 886 6287000
SGTC_1800 st050079 29.0735 µM 0.931446317064941 0.185813473631208 no 651 0.175811370724003 951 3645560
SGTC_814 3342-0569 96 µM 0.928963671709255 0.18645485556557 no 652 0.17645395675793 890 4346283
SGTC_649 1123-0311 367 µM 0.927420901661362 0.186854114279941 no 653 0.176854021266111 916 693629 YIL048W NEO1
SGTC_3074 9116018 49.47 µM 0.926361253339715 0.187128650539879 no 654 0.177129136566918 849 17027303
SGTC_584 0986-0246 15.4 µM 0.926258907072795 0.187155179864315 no 655 0.177155722922128 967 53315 YDR232W HEM1
SGTC_2771 fluoxetine 41.05 µM 0.922274307010641 0.188189841330902 no 656 0.178192756114007 842 3386 A selective serotonin reuptake inhibitor.
SGTC_952 1185-0122 232 µM 0.921781567021188 0.188318033477416 no 657 0.178321262080757 866 678600
SGTC_1431 4049-0260 9.09 µM 0.920910658772511 0.18854474229136 no 658 0.178548536631942 893 3854841
SGTC_1422 4031-0024 15.5 µM 0.92056211046612 0.18863552110991 no 659 0.178639545827723 877 782427
SGTC_2247 cerulenin 830 nM 0.918310408361105 0.189222622212746 no 660 0.179228189845517 890 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_165 k038-0023 64.381 µM 0.917571442171493 0.189415542664446 no 661 0.179421637287987 896 46368543
SGTC_3209 9113616 49.47 µM 0.916076971745906 0.189806070917798 no 662 0.179813262515971 935 16649353
SGTC_2236 dapsone 200 µM 0.915715007216841 0.189900732282363 no 663 0.179908195855407 957 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2778 tioconazole 65.09 nM 0.913320673689173 0.190527631778154 no 664 0.180536956205099 847 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_157 1348-1695 65.819 µM 0.910751519594813 0.191201715239419 no 665 0.181213155925843 890 5380510
SGTC_1239 0337-0584 35.4 µM 0.910060283425835 0.191383328085064 no 666 0.18139535930928 954 914301 YML130C ERO1
SGTC_654 1124-0271 80.9 µM 0.90937690392409 0.191562980580394 no 667 0.1815756044556 900 5403748
SGTC_2146 5545642 200 µM 0.907005162950448 0.192187284628617 no 668 0.182202033494257 928 825326
SGTC_1456 k015-0012 13 µM 0.906402325868275 0.192346165231541 no 669 0.182361471091441 979 2989616
SGTC_19 0279-0214 38.434 µM 0.906047270380554 0.192439779381912 no 670 0.18245541650006 989 3566274 YBR002C RER2
SGTC_818 4072-2707 53.5 µM 0.905353300629121 0.192622832293368 no 671 0.182639123727164 898 882871
SGTC_1702 st027038 51 µM 0.90485971680542 0.192753092845725 no 672 0.182769855183674 904 5521182
SGTC_2759 disulfiram 3.38 µM 0.904808606233173 0.192766584391753 no 673 0.182783395754241 861 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_851 0394-0702 453 µM 0.904318595967165 0.192895960610008 no 674 0.18291324448361 959 762646
SGTC_1817 st052116 64.4 µM 0.902499227964229 0.1933767877755 no 675 0.183395865682651 894 4361398
SGTC_633 0437-0093 97.7 µM 0.900070840265498 0.194019706501736 no 676 0.184041276397903 914 2831118
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.898544926297617 0.194424359654302 no 677 0.184447552485211 917 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1403 3909-7815 62.9 µM 0.8921503267783 0.196125707410678 no 678 0.186156181412007 885 6615483
SGTC_1631 benzylvanillin 81.9 µM 0.891766735987381 0.196228051858626 no 679 0.186258987316741 897 75506
SGTC_616 4092-0450 108 µM 0.891737818162732 0.196235768629434 no 680 0.186266738988879 934 787165
SGTC_731 3966-0296 387 µM 0.891640034767987 0.196261863657999 no 681 0.186292952151394 916 660956
SGTC_2903 5923464 63.88 µM 0.890141934563296 0.196661918105758 no 682 0.186694839221243 919 2876576
SGTC_1647 st011722 22.4 µM 0.889448169914894 0.196847349058634 no 683 0.186881133324414 882 2854783
SGTC_86 0417-1630 471.922 µM 0.889311753074381 0.196883823305138 no 684 0.186917778372685 1021 3634867
SGTC_1673 st016611 27.3 µM 0.8885115707595 0.1970978532242 no 685 0.18713281730347 949 5226799
SGTC_970 1315-0089 19.5 µM 0.887613749522048 0.19733816680222 no 686 0.187374277537369 882 6811083 YLR033W RSC58
SGTC_3178 9107506 49.47 µM 0.88379545137262 0.198362162104667 no 687 0.188403321139201 912 8897194
SGTC_1632 st005650 90 µM 0.88318631148575 0.19852581795793 no 688 0.188567808105567 890 2759605
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.88217548388117 0.198797573747849 no 689 0.188840958723913 1005 1377
SGTC_1287 0971-0001 34.6 µM 0.881927566514264 0.198864259284864 no 690 0.188907989342736 969 4665869
SGTC_49 0717-0965 32.132 µM 0.881870041524145 0.198879734451704 no 691 0.188923544747954 995 5889349 YGL099W LSG1
SGTC_2565 isoliquiritigenin 100 µM 0.880891406741939 0.199143114475432 no 692 0.18918829951456 758 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1925 st057770 10.1 µM 0.876734130672236 0.200264302471368 no 693 0.190315531920759 840 5989122
SGTC_595 3909-8003 73.7 µM 0.871726285300908 0.201619907656865 no 694 0.191678858529882 952 699517
SGTC_399 oxolinic acid 75 µM 0.871031940006374 0.201808297316479 no 695 0.19186835683155 921 4628 A DNA gyrase inhibitor.
SGTC_1328 1441-0025 69.2 µM 0.865261240975278 0.203378076793255 no 696 0.193447709557752 902 4562601
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.86398209484544 0.20372702154832 no 697 0.1937988633154 1037 6708561
SGTC_1836 st055642 81 µM 0.863700710695603 0.203803829624191 no 698 0.193876161564018 992 8571
SGTC_574 1315-0397 40 µM 0.862942490862926 0.204010883142861 no 699 0.1940845435211 1055 6794277
SGTC_1341 1486-1360 280 µM 0.862162864649151 0.204223912915799 no 700 0.194298950824091 947 3976547
SGTC_1157 4092-0394 27.6 µM 0.861753877392627 0.204335720016546 no 701 0.194411485268379 1032 3659885
SGTC_2070 5230947 200 µM 0.860997062872814 0.204542710658965 no 702 0.194619830363013 1036 2835538
SGTC_2926 9010726 65.15 µM 0.860614241186581 0.204647460839882 no 703 0.194725269890511 941 2994293
SGTC_304 1310-0298 97 µM 0.860544742380145 0.204666480981482 no 704 0.194744415482671 948 1550234
SGTC_3268 9137683 49.47 µM 0.858683686025837 0.205176198103324 no 705 0.195257526725052 938 1953228
SGTC_1195 1502-0147 41.1 µM 0.858491238587094 0.20522894974547 no 706 0.195310633171458 1001 817940
SGTC_2842 9000675 19.48 µM 0.857892278086028 0.205393181977925 no 707 0.195475974264438 905 2989072
SGTC_29 0299-0004 12.984 µM 0.856839982587359 0.205681905551183 no 708 0.195766662797249 868 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2581 avocatin a 64 µM 0.856823779433778 0.205686353173689 no 709 0.195771140843826 951 6710728 A skin care supplement.
SGTC_355 1311-2252 105 µM 0.856073161072445 0.205892453847027 no 710 0.195978656506181 916 5338538
SGTC_453 enantio-paf c16 10 µM 0.85400956928349 0.206459694578483 no 711 0.196549843637388 1025 13871343 A lipid and platelet activating factor
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.853026719515308 0.206730185800629 no 712 0.19682224351446 1116 688664
SGTC_3299 9121982 43.1275 µM 0.853011285404883 0.206734435112692 no 713 0.196826522948556 976 17594604 YPL160W CDC60
SGTC_2449 5812982 45.77 µM 0.850897325976781 0.207316937918699 no 714 0.197413195200977 914 776185
SGTC_712 r015-0009 80.6 µM 0.850677813306791 0.207377480336728 no 715 0.197474175550592 901 6813872 YLR060W FRS1
SGTC_2401 5128683 200 µM 0.850291197942346 0.207484135717719 no 716 0.197581604514296 930 708373
SGTC_412 gemfibrozil 100 µM 0.848464644998108 0.207988464179923 no 717 0.19808962706303 946 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3052 9092717 49.47 µM 0.848382051135964 0.208011286212062 no 718 0.198112617670175 937 25237534
SGTC_89 0302-0250 142.109 µM 0.847281904641597 0.208315415606302 no 719 0.198419005141735 1078 4203518 YLR208W SEC13
SGTC_867 0518-0118 155 µM 0.847103000623705 0.208364897414528 no 720 0.198468856382679 1014 6848158
SGTC_2546 rhodinyl acetate 100 µM 0.846637863167929 0.208493578962572 no 721 0.198598501346364 1001 6708682
SGTC_92 0063-0024 660.874 µM 0.846261901725271 0.208597623961209 no 722 0.198703328134938 1062 3594437
SGTC_417 st075190 100 µM 0.8440797548203 0.209202123742192 no 723 0.1993124199595 1005 222757
SGTC_1856 st057054 55.7 µM 0.843728803388619 0.209299440717087 no 724 0.199410484132588 1011 1266018
SGTC_82 0054-0107 293.755 µM 0.842745329403483 0.209572294761044 no 725 0.199685444856752 996 3104697
SGTC_829 1635-0120 117 µM 0.842347198929144 0.209682811149588 no 726 0.199796819439319 1024 285054
SGTC_2709 st078560 56 µM 0.841749081916235 0.209848905876016 no 727 0.199964209257955 995 17250903
SGTC_2266 7929956 200 µM 0.841281573018884 0.209978785078548 no 728 0.200095105612225 995 2967153
SGTC_684 1140-0066 328 µM 0.839986337882996 0.210338862521747 no 729 0.200458023372372 1032 6813534
SGTC_2871 9038510 12.99 µM 0.838679431192057 0.210702551871675 no 730 0.20082461185549 1040 4945164
SGTC_1159 4092-0538 61.2 µM 0.838430224556164 0.210771943589377 no 731 0.200894560182347 1040 717301
SGTC_1506 4226-2149 212 µM 0.837310907983749 0.211083783140555 no 732 0.201208914730503 1034 991114
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.836383106552372 0.211342471775289 no 733 0.201469706620867 964 140250 A respiratory chain inhibitor.
SGTC_701 4424-0219 185 µM 0.835908689648648 0.211474819928809 no 734 0.201603136749708 1051 2911779
SGTC_956 1185-0240 191 µM 0.833723968388552 0.21208491797592 no 735 0.202218274227878 968 1416193
SGTC_912 3474-0017 2.18 µM 0.832185729143937 0.212515098341548 no 736 0.202652058889765 1005 3360550
SGTC_2304 7443016 91.4 µM 0.8318221136124 0.212616860637042 no 737 0.202754679960547 922 939854
SGTC_2059 5238311 157 µM 0.830490424695066 0.212989793096835 no 738 0.203130779691589 966 703021
SGTC_2197 6588183 93.1375 µM 0.830346206140284 0.213030203635374 no 739 0.203171535324772 973 884136
SGTC_2529 gangaleoidin 93.61 µM 0.829361611067165 0.213306210076799 no 740 0.203449908664882 1005 4565183
SGTC_2167 5876490 200 µM 0.824948827645808 0.214545781372218 no 741 0.204700321773697 1021 686534
SGTC_476 mead acid 10 µM 0.821539144470504 0.215506438570494 no 742 0.205669618356327 997 5312531 An omega 9 fatty acid.
SGTC_370 0180-0345 38.7 µM 0.818468168041504 0.216373798764023 no 743 0.206544955557588 942 3989527
SGTC_2350 9023895 38.85 µM 0.818303691702958 0.216420310054676 no 744 0.206591899323835 992 2997209
SGTC_1635 st007035 42.4 µM 0.817539568475846 0.216636467810365 no 745 0.20681007326294 1064 3716403
SGTC_1316 1272-0050 65.9 µM 0.816879683106928 0.216823238858215 no 746 0.206998594716237 1010 7340392
SGTC_1539 benzyladenosine 56 µM 0.814638651644288 0.217458225067635 no 747 0.207639589552071 1030 92208 A nucleotide analog.
SGTC_1915 st067105 30.6 µM 0.814051708102649 0.217624710118406 no 748 0.2078076646784 1018 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.813950392302034 0.217653455531039 no 749 0.207836685251314 1011 2724 A muscle relaxant with antifungal properties.
SGTC_3318 9139014 38.6185 µM 0.812893493383911 0.217953450476243 no 750 0.208139562672429 988 16643984
SGTC_96 0929-0093 37.281 µM 0.812617972992203 0.21803169458366 no 751 0.208218561828341 971 6991579
SGTC_2553 4-methylesculetin 85.09 µM 0.810662077615222 0.218587608023805 no 752 0.208779878379094 1068 5319502
SGTC_1827 berberine 7.24 µM 0.808294776087472 0.219261543475028 no 753 0.20946045452585 950 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2612 dictamnine 15.46 µM 0.807670025121666 0.219439599739391 no 754 0.209640281799064 973 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_651 3253-0966 34.4 µM 0.807041305555343 0.219618870907114 no 755 0.209821343016627 1045 781462
SGTC_3234 9132280 49.47 µM 0.806912392040874 0.219655639298904 no 756 0.20985847940837 1036 17612295
SGTC_1114 scopoletin 1.73284 µM 0.806681276730149 0.219721566281076 no 757 0.209925066961266 1040 5280460 A coumarin with genotoxic properties.
SGTC_2835 9006588 71.43 µM 0.806251275525565 0.21984425684396 no 758 0.210048989359237 963 2345538
SGTC_83 0170-0301 39.027 µM 0.805858398734882 0.219956389211071 no 759 0.210162250407647 985 3089716
SGTC_1338 1486-1223 76 µM 0.803815362583149 0.220540028252825 no 760 0.210751808047884 1051 3444526
SGTC_562 3772-2733 112 µM 0.802947181524361 0.220788312029233 no 761 0.211002631924865 1087 2876874 YIL048W NEO1
SGTC_410 α-linolenic acid 100 µM 0.800410141719759 0.221514775244873 no 762 0.211736603485275 1054 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_61 0978-8327 98.565 µM 0.799371018570288 0.221812714702516 no 763 0.212037655028934 1101 6150059 YHR072W ERG7
SGTC_2646 retinol 96.75 µM 0.799012774520803 0.221915484185844 no 764 0.21214150238364 1034 445354 A vitamin A analog and teratogen.
SGTC_1349 flufenamic acid 69 µM 0.795988285535111 0.222784202554692 no 765 0.213019422149145 985 3371 A non-steroidal anti-inflammatory.
SGTC_1050 3232-1156 69.3 µM 0.795015203453633 0.223064110614268 no 766 0.213302329193176 989 700529
SGTC_927 2425-1185 123 µM 0.794049662314869 0.223342047349462 no 767 0.213583260244072 1063 730375
SGTC_2874 9043904 71.43 µM 0.79349510518758 0.223501768959502 no 768 0.213744710000702 950 4463428
SGTC_2397 5161689 200 µM 0.792796777583849 0.223702991235516 no 769 0.213948117134563 1034 2259942
SGTC_1459 k035-0031 35.7 µM 0.790322347308852 0.224416823915719 no 770 0.214669769516623 923 3877128 YMR208W ERG12
SGTC_123 0083-0120 66.675 µM 0.790241595695492 0.224440141198337 no 771 0.214693344040001 1041 16001701
SGTC_194 1486-1323 56.904 µM 0.789898517122151 0.224539221544831 no 772 0.214793518735383 1074 5178754
SGTC_3355 9151058 44.0485 µM 0.788839849764034 0.224845118770611 no 773 0.215102807632471 1090 17015728
SGTC_3242 9133940 49.47 µM 0.788318311444921 0.224995901772338 no 774 0.215255269685077 1118 17248444
SGTC_1087 pterostilbene 9.05 µM 0.788139647184505 0.225047568934469 no 775 0.215307513285785 1066 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2539 epi(13)torulosol 80 µM 0.788034130381499 0.225078086050191 no 776 0.215338371136707 1044 6708597
SGTC_2652 actinonin 100 µM 0.787969954549227 0.225096647854925 no 777 0.215357140286485 1041 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_890 0929-0006 47.2 µM 0.787796670427226 0.225146771771631 no 778 0.215407824474088 1030 1378169
SGTC_1685 st024049 53.0905 µM 0.787609651828463 0.2252008755975 no 779 0.215462533647627 1024 1941139
SGTC_1080 nisoldipine 24.4 µM 0.787553324561171 0.225217172321687 no 780 0.21547901282993 1083 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3340 9146634 11.102 µM 0.787236465026385 0.225308859239797 no 781 0.21557172731082 1053 4907387
SGTC_1357 1503-1303 39.5 µM 0.786621805734026 0.225486778170255 no 782 0.215751645248809 1094 292895
SGTC_2442 5158906 48.48 µM 0.785016189381021 0.225951913972865 no 783 0.216222038316611 1051 1893835
SGTC_1454 4239-0054 42.6 µM 0.782117270192269 0.226793082876604 no 784 0.217072829035506 1109 1340767
SGTC_430 0958-0115 16.4 µM 0.781356037865423 0.227014259435161 no 785 0.217296559929171 983 6833180
SGTC_1419 3993-2473 62.6 µM 0.780963861101708 0.227128254109566 no 786 0.217411875065558 1076 704026
SGTC_931 2812-0076 566 µM 0.780756379899294 0.227188576066252 no 787 0.2174728968515 1114 3450959
SGTC_2091 4-phenylthiadiazole 200 µM 0.78044893311159 0.227277978075183 no 788 0.21756333744735 1068 270010
SGTC_935 2996-0153 430 µM 0.779559964217763 0.227536591562841 no 789 0.217824964552916 1067 23738523
SGTC_2993 9054257 71.4286 µM 0.777871411987609 0.228028271059712 no 790 0.218322411608902 1126 6470217 YGL055W OLE1
SGTC_291 SEC14.278 35.5 µM 0.777838796509636 0.228037774046127 no 791 0.218332026558579 1093 1068044
SGTC_2654 protoveratrine a 100 µM 0.77429026400883 0.229073019302672 no 792 0.219379579925572 1089 5702278 A heart drug and vasodilator.
SGTC_1254 0550-0035 264 µM 0.773410246501212 0.229330162093896 no 793 0.219639813905041 1094 15121435
SGTC_2258 7960471 200 µM 0.771753330647714 0.229814754936895 no 794 0.220130268813171 1033 2974708
SGTC_1130 3454-2858 15.9 µM 0.77035690240852 0.230223608633393 no 795 0.220544105506468 1005 715628 YIL048W NEO1
SGTC_2973 9094665 17.96 µM 0.767486080747965 0.231065419650177 no 796 0.221396282937027 1116 25237061 YIL048W NEO1
SGTC_552 k242-0005 476 µM 0.76629814803844 0.231414259030912 no 797 0.221749460005482 1079 4088318
SGTC_1981 st071826 47 µM 0.765169783682319 0.231745877790279 no 798 0.222085225029576 1043 11838600
SGTC_1616 st002734 56.1 µM 0.76292735773255 0.232405697079324 no 799 0.222753359758021 1084 4026101
SGTC_2600 tangeritin 87.95 µM 0.762301089657855 0.232590158886515 no 800 0.222940161854086 1084 68077 A bioactive flavone.
SGTC_2358 9037157 4 µM 0.761660253359849 0.232778995864871 no 801 0.223131401671063 1085 2388925
SGTC_2908 7930301 100 µM 0.761546933152564 0.232812397101383 no 802 0.223165228659356 1097 2223178
SGTC_2972 9093619 59.92 µM 0.759178468393974 0.233511113442389 no 803 0.223872902204462 1075 25236256
SGTC_3143 9086658 49.47 µM 0.757782734996552 0.233923410156407 no 804 0.224290529881069 1131 25236626
SGTC_1660 st012960 28.1 µM 0.755774983988771 0.234517202318957 no 805 0.22489205888101 1067 24207266
SGTC_2131 toluylene red 5.2905 µM 0.754625743561596 0.234857464939759 no 806 0.225236786347775 1072 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1478 0453-0656 35.7 µM 0.752426385854498 0.235509402288579 no 807 0.225897341921959 1135 5258496
SGTC_934 2950-0684 338 µM 0.751759830878285 0.235707180635475 no 808 0.226097751278628 1125 1121253
SGTC_2334 9017922 200 µM 0.750099381610221 0.2362002625992 no 809 0.226597425969326 1115 3163164
SGTC_3193 9111931 49.47 µM 0.748812375795134 0.236582838420279 no 810 0.226985149720835 1149 17087244
SGTC_1627 st003713 25.6 µM 0.748248839128643 0.236750462805133 no 811 0.227155038643326 1156 16195070 YER133W GLC7
SGTC_1985 st071382 65.5 µM 0.747330082515867 0.237023887615911 no 812 0.227432169045259 1175 6123237
SGTC_2924 9010168 62.78 µM 0.746829384701918 0.237172969864078 no 813 0.227583277851934 1143 2993929
SGTC_540 1187-0821 17.3 µM 0.74318955464685 0.23825827231464 no 814 0.228683463194231 1091 847520
SGTC_688 0527-0193 473 µM 0.742849030583816 0.238359946696312 no 815 0.22878654350729 1084 4007154
SGTC_1679 SEC14.276 6.7 µM 0.742408834752152 0.238491416486489 no 816 0.228919834185951 1154 1005053 YMR079W SEC14
SGTC_363 0455-0021 3.06 µM 0.741101509392703 0.238882098879472 no 817 0.229315947250023 1127 4597466
SGTC_1430 4049-0248 69.1 µM 0.74073236096489 0.238992478893908 no 818 0.229427866912922 1177 22774488
SGTC_3353 9151644 39.2805 µM 0.740721673971508 0.23899567485438 no 819 0.229431107487458 1118 4909158
SGTC_1719 st032227 49.2 µM 0.740428295929885 0.239083419096946 no 820 0.229520077362772 1173 3125804
SGTC_1953 st076800 12.1 µM 0.740031199703087 0.239202211676493 no 821 0.229640531618489 1057 297591
SGTC_1676 st018489 23.4 µM 0.740023186321047 0.239204609236772 no 822 0.229642962743804 1089 3696235
SGTC_2302 7771753 200 µM 0.739472071212177 0.239369531379505 no 823 0.229810196384423 1138 2203047
SGTC_1074 carmofur 3.8 µM 0.738683710327166 0.239605557652783 no 824 0.230049539787026 1185 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3183 9108214 49.47 µM 0.73862144802181 0.239624203689229 no 825 0.230068448330254 1047 4974831
SGTC_126 0417-1624 672.48 µM 0.734597709295087 0.240830892860385 no 826 0.231292266751567 1251 41912 YDL195W SEC31
SGTC_1558 st069300 45.6 µM 0.734341999053534 0.240907690020213 no 827 0.231370163438068 1080 24208000
SGTC_2112 5488546 200 µM 0.733955143759251 0.241023899138246 no 828 0.231488038481333 1134 600757
SGTC_940 3232-1287 54.8 µM 0.733472532959816 0.241168915387254 no 829 0.231635137211419 1124 1585493 YIL048W NEO1
SGTC_698 k064-0052 127 µM 0.73343934303324 0.241178890132368 no 830 0.23164525534354 1163 5088751
SGTC_2312 7706453 155.7 µM 0.733206840609204 0.241248771609548 no 831 0.231716141895415 1127 976098
SGTC_2911 7942208 15.64 µM 0.732734780788806 0.241390688869 no 832 0.23186010313208 1118 1243384
SGTC_3220 9131269 49.47 µM 0.732171440803644 0.241560107393945 no 833 0.232031966709587 1165 17722206
SGTC_2317 5986382 200 µM 0.730980210242042 0.24191856987157 no 834 0.232395620388164 1178 877883
SGTC_302 1094-0063 18.9 µM 0.730769649542525 0.241981961332096 no 835 0.232459932395601 1091 5440289
SGTC_3328 9140624 29.0385 µM 0.727828142078936 0.242868473728529 no 836 0.233359397564545 1151 4904392
SGTC_1005 4092-0690 4.4 µM 0.726885362364361 0.243152980408204 no 837 0.233648092395379 1124 1529343
SGTC_2564 betulinic acid 100 µM 0.725214248341749 0.243657722142056 no 838 0.234160301533366 1192 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_63 0099-0242 26.702 µM 0.725202933470938 0.243661141602337 no 839 0.234163771744988 1174 3898502 YLR359W ADE13
SGTC_1184 1269-1718 139 µM 0.721797515961246 0.244691467251351 no 840 0.235209488455466 1171 5403821
SGTC_3075 9116269 49.47 µM 0.721650061799893 0.244736133151453 no 841 0.235254826032768 1158 17015205 YNL244C SUI1
SGTC_2673 kobusone 100 µM 0.721592359717767 0.244753613103209 no 842 0.235272568945243 1207 6710676 An epoxy ketone and protein crosslinker.
SGTC_1615 st002656 86.5 µM 0.72130243454282 0.244841451614705 no 843 0.235361729716967 1165 1584458
SGTC_3221 9128209 49.47 µM 0.72082505075116 0.244986121347914 no 844 0.235508580319958 1157 16460723
SGTC_48 0382-0018 55 µM 0.720034391998925 0.245225829250211 no 845 0.23575191029012 1258 762596
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.719159276952096 0.245491289142819 no 846 0.236021393748386 1140 2374 Ca(2+)-ATPase inhibitor.
SGTC_1122 capsaicin 818.572 nM 0.717285508685567 0.246060202166 no 847 0.23659897347708 1170 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2889 9059656 51.95 µM 0.711892463450909 0.247701576667484 no 848 0.238265684718444 1228 3949838
SGTC_1748 st037455 53.6035 µM 0.711056087141188 0.247956650664794 no 849 0.238524740205178 1153 580690
SGTC_2469 5655019 90.81 µM 0.711024429406996 0.247966308239753 no 850 0.238534548758837 1207 2788239
SGTC_3051 9093778 49.47 µM 0.710631324288576 0.248086246433219 no 851 0.238656363378891 1166 17217378
SGTC_993 3909-8757 62.7 µM 0.710141858532188 0.248235627949155 no 852 0.238808085608223 1103 4288324 YLR208W SEC13
SGTC_3192 9110362 49.47 µM 0.709476346094345 0.248438814595153 no 853 0.239014462548502 1219 16649480
SGTC_2595 hexamethylquercetagetin 100 µM 0.70910936321035 0.248550895514029 no 854 0.239128306480915 1101 386331
SGTC_1108 betulinic acid 729.144 nM 0.705317422428661 0.249710574694848 no 855 0.240306360267543 1206 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2025 5147754 141 µM 0.704536654598542 0.249949711081927 no 856 0.240549315748902 1195 315777 YLR208W SEC13
SGTC_2381 9035592 200 µM 0.704098511505707 0.250083960347656 no 857 0.240685713517614 1135 4749657
SGTC_713 1488-1073 324 µM 0.703398148563308 0.250298634523438 no 858 0.240903830010322 1165 3312542
SGTC_918 glabranin 770.725 nM 0.702582558656777 0.25054875097479 no 859 0.241157967494596 1197 124049 Also referred to as licorice root.
SGTC_1841 st054148 70 µM 0.70210526449677 0.25069518387805 no 860 0.241306759733834 1138 675442
SGTC_1276 0871-0068 94.2 µM 0.701664648211557 0.250830404305351 no 861 0.241444162238941 1157 3414906
SGTC_922 1866-0035 480 µM 0.699819070006102 0.251397211848386 no 862 0.242020151902818 1185 3156169
SGTC_3118 9124250 49.47 µM 0.698135240557074 0.251914933672338 no 863 0.242546310554774 1095 1504786
SGTC_544 k015-0020 52.4 µM 0.697646850750911 0.252065202582842 no 864 0.242699037151901 1190 3008304
SGTC_848 0368-0089 85.6 µM 0.695967767017183 0.252582187519476 no 865 0.243224508003335 1182 762535
SGTC_1940 st075990 51.1 µM 0.694260020962716 0.253108569910648 no 866 0.243759578990522 1294 1084979
SGTC_638 3970-0837 4.09 µM 0.69258277297274 0.253626112933438 no 867 0.244285712192875 1201 4118451 YLR208W SEC13
SGTC_2403 6032726 181.2 µM 0.691800829445515 0.253867584570575 no 868 0.244531207843531 1200 2881040
SGTC_3278 9139605 49.47 µM 0.690301525539273 0.254330921241972 no 869 0.245002294362761 1223 7958859
SGTC_1971 st069429 63.5 µM 0.690270664409461 0.254340463050498 no 870 0.24501199616317 1196 1246522 YGL099W LSG1
SGTC_2346 9031566 143.75 µM 0.689770448478731 0.254495148643108 no 871 0.245169277655361 1171 4771086
SGTC_2483 5729050 27.16 µM 0.688717722161722 0.254820852198915 no 872 0.245500460726819 1239 2865180
SGTC_2234 tolnaftate 200 µM 0.687471925046608 0.25520657174038 no 873 0.245892693332928 1187 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2427 5545055 42.75 µM 0.687036511951234 0.255341454849985 no 874 0.246029860106002 1227 5372858
SGTC_2881 9058953 51.95 µM 0.686617144122445 0.255471402644644 no 875 0.246162010989275 1192 17122249
SGTC_1947 st076332 61.6 µM 0.685243867876815 0.255897175857599 no 876 0.246595023092552 1192 24208416
SGTC_2981 9013952 38.96 µM 0.683124925765947 0.256554862527029 no 877 0.247263953119847 1140 2996344
SGTC_2775 cyproheptadine 69.59 µM 0.681429034389351 0.257081874441982 no 878 0.247800028202831 1233 2913 A selective serotonin reuptake inhibitor.
SGTC_1831 st055328 12 µM 0.679225846661521 0.25776737268471 no 879 0.24849738640789 1229 1103068
SGTC_797 k781-0471 270 µM 0.676872081285223 0.258500768384145 no 880 0.249243559616175 1218 23738129
SGTC_2679 rapamycin 1 nM 0.674070138461334 0.259375215947596 no 881 0.250133361646383 1227 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3252 9135871 49.47 µM 0.673771235905586 0.259468589423116 no 882 0.250228382325063 1258 17682838
SGTC_2475 5812728 15.03 µM 0.672504847252525 0.259864386144049 no 883 0.250631177655199 1238 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2845 9003024 42.97 µM 0.671775248462807 0.260092556057969 no 884 0.250863394152047 1278 2990173
SGTC_1656 st012921 11 µM 0.670866814898007 0.260376797873135 no 885 0.25115268924297 1184 6732821
SGTC_917 harmaline 728.087 nM 0.670824515286514 0.260390036991148 no 886 0.25116616405834 1219 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2313 7726885 200 µM 0.669599667665936 0.260773545504435 no 887 0.251556512988741 1222 726423
SGTC_1244 0416-0015 52.5 µM 0.668830757871319 0.261014445034094 no 888 0.251801721916407 1250 96201
SGTC_2662 daunorubicin 22.37 µM 0.665855548279418 0.261947655276551 no 889 0.252751717738514 1198 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3324 9138759 60.749 µM 0.66562025615868 0.262021530407324 no 890 0.252826927858594 1248 45595710
SGTC_1209 2323-2347 50.3 µM 0.663873127743115 0.262570413645479 no 891 0.253385758314004 1223 5412760
SGTC_2036 5160441 105 µM 0.661150823531881 0.263426832369299 no 892 0.254257797335007 1272 134534 YIL048W NEO1
SGTC_2280 7785178 200 µM 0.659152262914461 0.264056472656693 no 893 0.25489899889396 1258 2954328
SGTC_1991 st073000 8.92 µM 0.658518643822268 0.264256252347801 no 894 0.255102460506912 1318 4301969 YIL048W NEO1
SGTC_3144 9087057 49.47 µM 0.656979793477359 0.264741771124631 no 895 0.255596954637118 1202 17249618
SGTC_3093 9117344 49.47 µM 0.656785015303182 0.264803257417383 no 896 0.25565958032616 1265 24824913
SGTC_1267 0828-0272 9.49 µM 0.655650525906097 0.265161529798196 no 897 0.256024504107422 1295 745334
SGTC_2297 7971671 152.32 µM 0.655471048430511 0.265218231428804 no 898 0.256082260336652 1293 909016
SGTC_2452 5863136 48.41 µM 0.654295575890429 0.2655897461002 no 899 0.256460697810691 1230 2184096
SGTC_3211 9128781 49.47 µM 0.654144244553047 0.265637594386568 no 900 0.256509439335925 1260 17194361
SGTC_2623 humulene 100 µM 0.653966953512438 0.265693656231033 no 901 0.256566548225116 1206 6187145 An anti-inflammatory.
SGTC_201 4262-0159 12.803 µM 0.653662205649832 0.265790035676905 no 902 0.256664728906336 1222 1341029
SGTC_963 1269-2853 151 µM 0.653548676068016 0.265825945030372 no 903 0.256701309755845 1242 3668223
SGTC_2158 5657123 3.6195 µM 0.652924038859602 0.266023561457996 no 904 0.256902625310925 1237 2858827
SGTC_364 0083-0097 67.7 µM 0.651874426908554 0.266355794606356 no 905 0.257241091724237 1304 5207356
SGTC_3146 9095609 49.47 µM 0.651652001905993 0.266426225632498 no 906 0.257312846455931 1309 17173999
SGTC_1870 st057514 26.5 µM 0.65107117294299 0.266610189928621 no 907 0.257500272030245 1268 5393161
SGTC_1445 4239-0156 97.7 µM 0.650435222206963 0.266811686419432 no 908 0.257705565947756 1329 4008346
SGTC_1875 nocodazole 6 µM 0.64980776033813 0.267010568663418 no 909 0.257908202781993 1258 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_375 3970-0961 9.27 µM 0.647547968763514 0.267727458954461 no 910 0.258638679764866 1243 2898222
SGTC_3000 9075062 71.4286 µM 0.6473081463298 0.267803596477171 no 911 0.258716265121835 1265 17057871
SGTC_199 4063-0024 41.6 µM 0.646586668771543 0.268032713001943 no 912 0.258949744148978 1291 306215
SGTC_2099 5377090 177.372 µM 0.646410493480293 0.268088675218448 no 913 0.259006773195763 1269 2243829
SGTC_3267 9137951 49.47 µM 0.6455164581424 0.268372756852695 no 914 0.259296278130787 1278 16643986
SGTC_2806 7952793 58.44 µM 0.642668446749298 0.269278726674461 no 915 0.260219629642688 1299 2972490
SGTC_2570 licareol 100 µM 0.641293934945873 0.269716515385749 no 916 0.260665864496204 1246 443158
SGTC_2259 7964009 200 µM 0.639814969426292 0.270187970923522 no 917 0.261146449711132 1303 313134
SGTC_1451 4152-0210 104 µM 0.638419071025413 0.270633324589439 no 918 0.261600459898957 1306 659563
SGTC_2781 5567276 71.43 µM 0.638260084362445 0.270684071651934 no 919 0.261652195340821 1294 2853274
SGTC_2134 5324836 1.464 µM 0.638250741234901 0.270687054039073 no 920 0.26165523582731 1271 699272
SGTC_3301 9125354 19.7965 µM 0.636646999020497 0.271199222001542 no 921 0.262177402030155 1276 41905162
SGTC_1941 st076221 61.8 µM 0.636306170336997 0.271308130596732 no 922 0.262288441997104 1272 2828568
SGTC_2370 9071495 200 µM 0.635041817691138 0.271712332890536 no 923 0.262700570928857 1240 21791103
SGTC_1957 st077035 62.4 µM 0.634672898338083 0.271830329592067 no 924 0.262820886445269 1352 705593
SGTC_2728 chlorpromazine 9.18 µM 0.634563318424982 0.271865382998466 no 925 0.26285662912473 1300 2726 A thorazine and dopamine antagonist.
SGTC_734 2023-0417 80 µM 0.634106931164002 0.272011400437251 no 926 0.263005519848889 1277 3935732
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.631671181550681 0.272791357871227 no 927 0.263800881467439 1281 97141
SGTC_707 0865-0008 204 µM 0.63082232241964 0.273063433625018 no 928 0.264078353034513 1314 723043
SGTC_1954 st077032 68.9 µM 0.63075964695212 0.273083527654398 no 929 0.264098846025753 1215 698907
SGTC_64 000l-0018 272.079 µM 0.630646096645991 0.273119934246414 no 930 0.264135975621282 1270 6811119
SGTC_1833 st055984 71 µM 0.630260128376378 0.273243701689352 no 931 0.264262202518936 1301 676288
SGTC_1261 0712-0010 12.7 µM 0.629119073101113 0.273609763332282 no 932 0.264635552299855 1314 2840123
SGTC_2719 novobiocin 32.65 µM 0.626436870892286 0.274471194391474 no 933 0.265514215928929 1332 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3218 9131285 49.47 µM 0.623882072774044 0.275292950235433 no 934 0.266352517246737 1358 17156417
SGTC_2852 9023854 51.95 µM 0.623687239674169 0.27535566834649 no 935 0.266416502402238 1361 19798528
SGTC_3310 9130229 44.1445 µM 0.623264441365048 0.275491794202237 no 936 0.266555380375191 1340 7761258
SGTC_3004 9076122 71.4286 µM 0.620781809084311 0.276291779744201 no 937 0.267371596847914 1307 44782551
SGTC_1131 3454-3128 32.3 µM 0.618971416082578 0.276875865461529 no 938 0.267967594724338 1412 710982
SGTC_911 3456-4043 236 µM 0.617794299829916 0.277255961707708 no 939 0.268355470694633 1393 914281
SGTC_1170 0310-0127 64.8 µM 0.617588779570225 0.277322351304985 no 940 0.268423221385905 1336 774975
SGTC_2038 4100038 30.985 µM 0.617280410279417 0.277421978999452 no 941 0.268524892861293 1327 3596803
SGTC_987 1497-1013 404 µM 0.616924201833444 0.277537084303087 no 942 0.268642361326617 1305 1676435
SGTC_1052 3253-3998 198 µM 0.616230377006459 0.277761354044821 no 943 0.268871241177083 1286 5450317
SGTC_1905 st060207 84.5 µM 0.615618609091896 0.277959173358566 no 944 0.269073133187502 1263 1948547
SGTC_1406 3909-7906 11.9 µM 0.615202323582371 0.278093821406309 no 945 0.269210556740885 1321 X1406
SGTC_1313 1220-0047 237 µM 0.615063861716801 0.278138614113327 no 946 0.269256273367578 1364 3528706
SGTC_787 4152-0075 138 µM 0.613753002558246 0.278562854098492 no 947 0.269689278945056 1348 9566539
SGTC_535 2293-4129 48.2 µM 0.610121394166026 0.279739813329992 no 948 0.270890697741883 1352 396118 YIL048W NEO1
SGTC_2299 7976368 114.88 µM 0.60922181590725 0.280031727912764 no 949 0.271188710937093 1378 2979718
SGTC_2496 diffractaic acid 79.83 µM 0.60781710753095 0.28048785313205 no 950 0.271654390817546 1414 94870 An apoptosis inducer which activates caspases.
SGTC_1862 st057513 3.81 µM 0.606694752271374 0.280852553256771 no 951 0.272026752712796 1307 5393163
SGTC_2917 7979103 53.79 µM 0.606294546344016 0.280982652311191 no 952 0.272159589713207 1373 2980565
SGTC_551 k048-0028 34.9 µM 0.603587480139857 0.281863430068398 no 953 0.273058969324107 1360 6836383
SGTC_101 0490-5701 117.494 µM 0.601986970669949 0.282384800825458 no 954 0.273591405192572 1254 4661669
SGTC_431 k089-0097 107 µM 0.601436264347885 0.282564302270254 no 955 0.273774725456557 1287 5499420
SGTC_2746 daunorubicin 9.88 µM 0.600591355900032 0.282839804804464 no 956 0.274056098381239 1273 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3174 9107204 49.47 µM 0.600559108621311 0.282850322353705 no 957 0.274066840258022 1362 3938802
SGTC_2157 5649910 96.377 µM 0.597068880690566 0.283989779863061 no 958 0.275230696787071 1312 2858091
SGTC_2809 7964133 12.99 µM 0.594155345120177 0.284942642956475 no 959 0.276204108314124 1375 1253665
SGTC_209 4077-0173 175.592 µM 0.593142150992735 0.285274362043505 no 960 0.276543011725003 1314 15993494
SGTC_3260 9137109 49.47 µM 0.592798287045086 0.285386984674088 no 961 0.276658077129494 1268 17478346
SGTC_856 0433-0016 11.3 µM 0.592328300761962 0.285540949245764 no 962 0.276815384134464 1343 3911780
SGTC_1693 xanthone 101.9 µM 0.590123023472668 0.2862639118214 no 963 0.277554087158294 1406 7020 An insecticide.
SGTC_469 w7 172 µM 0.589726487412819 0.286394001548957 no 964 0.277687017179886 1378 45115570 A P450 inhibitor.
SGTC_1706 st031321 9.9705 µM 0.588745575073191 0.286715925364039 no 965 0.27801598008295 1389 6103185
SGTC_1965 Pectolinarigenin 58.4 µM 0.588204052214358 0.286893720224057 no 966 0.278197668901425 1340 5320438 An anti-inflammatory.
SGTC_2196 6573537 42.6665 µM 0.588016281593488 0.286955381989132 no 967 0.278260682200325 1418 2903087
SGTC_2242 6630449 61.2675 µM 0.587693920637942 0.287061256348935 no 968 0.278368878433437 1374 691249 YDR170C SEC7
SGTC_37 0566-0070 1.56 µM 0.586368602418483 0.287496730419055 no 969 0.278813919446915 1389 1626686
SGTC_2132 5317594 122.667 µM 0.583929753888482 0.288298904450272 no 970 0.279633787008081 1395 794577
SGTC_1256 0570-0116 285 µM 0.580565392979762 0.289407222563337 no 971 0.280766700990103 1347 410638
SGTC_1425 4048-4433 7.33 µM 0.577599339211795 0.290385983837117 no 972 0.28176732658716 1410 23734946
SGTC_398 bronopol 33.3 µM 0.576810428711617 0.290646575293315 no 973 0.28203376192792 1366 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_236 1509-0011 5.31 µM 0.575968203303295 0.29092489830264 no 974 0.282318336919469 1409 3107280
SGTC_2348 9022543 33.42 µM 0.573382093858297 0.29178028516484 no 975 0.283193005804399 1404 3162678 YDL140C RPO21
SGTC_1200 1643-0193 18.4 µM 0.572590378429121 0.292042388682013 no 976 0.28346103793309 1369 5403974
SGTC_3070 9117005 49.47 µM 0.572366930105443 0.292116382805409 no 977 0.283536707475533 1433 8779016
SGTC_2606 farnesol 9.78 µM 0.571735476903661 0.292325533457106 no 978 0.283750597932045 1439 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_244 nsc-207895 1.295 µM 0.571199710834502 0.2925030451002 no 979 0.283932137108924 1298 42640
SGTC_2956 9076196 2.52 µM 0.570786358430076 0.292640032502474 no 980 0.284072235567057 1407 16423868
SGTC_3019 9081971 49.47 µM 0.570753505404239 0.292650921465593 no 981 0.284083371935186 1460 16451803
SGTC_1852 st056254 31.4 µM 0.570244164919311 0.292819763771671 no 982 0.284256052548271 1390 442583
SGTC_479 n-linoleoylglycine 10 µM 0.569307840997484 0.293130265604417 no 983 0.284573623283705 1378 6433346 An anti-infammatory.
SGTC_811 0416-0114 265 µM 0.56848985567275 0.293401649130402 no 984 0.284851195987392 1390 6612453
SGTC_2703 st077852 53.4 µM 0.568302178607184 0.293463931287209 no 985 0.284914899977465 1396 6281836
SGTC_187 1488-2104 32.728 µM 0.566065815663749 0.294206557284993 no 986 0.285674520215362 1439 2852859
SGTC_1883 5-benzylidenerhodanine 20 µM 0.564029602265091 0.294883474061347 no 987 0.286366993097115 1411 1273210
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.563940304943922 0.294913176398043 no 988 0.286397379445521 1413 4213774
SGTC_2283 7944793 200 µM 0.562281465188015 0.295465195059178 no 989 0.286962132265584 1336 2970533
SGTC_449 xestospongin c 11.1929 µM 0.561766989968544 0.29563649551214 no 990 0.287137392729542 1416 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_861 0443-0273 110 µM 0.561386350647093 0.295763263134737 no 991 0.287267093437307 1415 6149169
SGTC_799 1310-0557 151 µM 0.559758005149422 0.296305846920402 no 992 0.287822255765337 1409 5354492
SGTC_529 4076-0302 30.3 µM 0.559158996232524 0.296505558479272 no 993 0.288026607159791 1382 5816522
SGTC_2441 5730946 39.09 µM 0.556916513977292 0.29725375659371 no 994 0.288792235560461 1456 1774275
SGTC_700 3453-2283 142 µM 0.554275598165343 0.298135995662949 no 995 0.289695123828503 1473 565664
SGTC_1222 0366-0074 1.18 µM 0.552295455194 0.298798274724109 no 996 0.290372971944573 1462 286520
SGTC_652 0437-0092 114 µM 0.552019093617987 0.298890759822037 no 997 0.290467635842622 1371 3091274
SGTC_409 arachidonic acid 100 µM 0.550954765924182 0.299247061191482 no 998 0.290832341686864 1421 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_824 1304-0008 100 µM 0.548733112182233 0.299991416916029 no 999 0.291594309466621 1420 768245
SGTC_2848 9016370 25.97 µM 0.548159074681351 0.300183881877249 no 1000 0.291791340180623 1443 7894410
SGTC_2092 5303694 80.6725 µM 0.547634759315315 0.300359724628784 no 1001 0.291971358620575 1381 1963699
SGTC_297 0986-0032 24 µM 0.546561419193132 0.300719842156513 no 1002 0.292340040423154 1378 2847425
SGTC_2648 atorvastatin 78.68 µM 0.545460685706248 0.301089352694268 no 1003 0.292718356277227 1455 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2119 5528445 120.635 µM 0.545246783553853 0.301161182278665 no 1004 0.292791899610158 1473 791935
SGTC_2224 6650123 117.647 µM 0.543869947844833 0.301623716366753 no 1005 0.293265485213713 1399 2908370
SGTC_1249 0481-0015 10.2 µM 0.54277747207513 0.301990949775547 no 1006 0.293641512929475 1373 4227577
SGTC_1781 st038725 66.3 µM 0.540992262862347 0.302591475852206 no 1007 0.29425645782412 1424 4270275 YIL048W NEO1
SGTC_1345 1488-0192 31.4 µM 0.540191762394789 0.302860929686165 no 1008 0.294532396513843 1438 658348
SGTC_2253 7938677 135.83 µM 0.539896967241952 0.30296018677283 no 1009 0.294634044753702 1527 2301972
SGTC_1640 st009078 66.4 µM 0.539312586819338 0.303156989807832 no 1010 0.294835592635178 1479 690618
SGTC_174 3553-0389 74.3 µM 0.538605580901417 0.30339516608844 no 1011 0.295079517937722 1441 738071
SGTC_3223 9129970 49.47 µM 0.534760474289206 0.304691967445663 no 1012 0.296407748991512 1483 17248386
SGTC_668 1682-0499 62.6 µM 0.534705768399354 0.304710435335703 no 1013 0.296426666031269 1443 682214
SGTC_1447 4239-0816 81.9 µM 0.533526123090384 0.305108786953801 no 1014 0.296834716388046 1379 1341554
SGTC_1043 0916-0009 19.3 µM 0.533146998053817 0.305236861860977 no 1015 0.296965913856572 1553 3101130
SGTC_204 PMA1.184 62.41 µM 0.532919003464135 0.305313893809285 no 1016 0.297044824907026 1435 2252213 YGL008C PMA1
SGTC_2472 5377652 49.4 µM 0.532315925227245 0.30551769587201 no 1017 0.297253602118307 1406 1610903
SGTC_878 0828-0289 13.7 µM 0.532289093742769 0.305526764607153 no 1018 0.297262892359153 1438 745350 YLR208W SEC13
SGTC_360 0957-0399 1.01 µM 0.531146400498744 0.305913092552645 no 1019 0.297658666143474 1512 6752301 YPR165W RHO1
SGTC_1545 lovastatin 49.4 µM 0.531142282992137 0.305914485012548 no 1020 0.297660092683712 1480 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1101 ebselen 5.29 µM 0.530366628852329 0.306176846037739 no 1021 0.297928879356564 1504 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3037 9091026 49.47 µM 0.530029773217996 0.306290816701671 no 1022 0.298045644062673 1450 25236398 YIL048W NEO1
SGTC_1881 5652484 16 µM 0.52915848944807 0.306585691010743 no 1023 0.298347754970285 1492 2255129
SGTC_3349 9149703 23.001 µM 0.528906813245255 0.306670890770613 no 1024 0.298435047688092 1409 4910494
SGTC_1912 st060209 90.8 µM 0.528332247209841 0.306865437334256 no 1025 0.298634376780169 1391 688787
SGTC_2557 derrustone 83.84 µM 0.526450317889472 0.307503034420055 no 1026 0.299287681287833 1406 629853 An antioxidant.
SGTC_1573 oleylamine 1.06 µM 0.525842901422319 0.307708951279096 no 1027 0.299498681890852 1436 5356789 An amine of the fatty acid oleic acid.
SGTC_69 0096-0274 206.684 µM 0.524341565479359 0.308218170631614 no 1028 0.30002049583281 1534 6741392
SGTC_1045 1348-1485 165 µM 0.522698739933717 0.308775803263684 no 1029 0.300591957634344 1430 6810614
SGTC_2681 menadione 3.18 µM 0.522614362047908 0.308804456000389 no 1030 0.300621321999869 1440 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1358 1509-0022 2.48 µM 0.521940188224136 0.309033431289364 no 1031 0.300855987865363 1450 3258434
SGTC_1192 1488-0095 21.4 µM 0.520609868372918 0.309485476598692 no 1032 0.301319286695553 1463 915875
SGTC_382 3229-0966 23.2 µM 0.519828467362618 0.309751132710541 no 1033 0.301591568052575 1537 5722370
SGTC_2029 5175081 200 µM 0.519004027464689 0.310031528694452 no 1034 0.30187896635623 1440 1380876
SGTC_2293 7624732 200 µM 0.518472642789043 0.310212313767771 no 1035 0.302064271320474 1393 894453
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.517660247828298 0.310488791448146 no 1036 0.302347669145474 1462 7104
SGTC_463 ikarugamyin 104 µM 0.517609276040489 0.310506141954157 no 1037 0.302365454243068 1492 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1921 5740136 50 µM 0.517090740101959 0.310682672586292 no 1038 0.302546408681992 1565 1774243
SGTC_2142 5622915 118.518 µM 0.516458050153304 0.310898124914069 no 1039 0.302767265377911 1437 5322196
SGTC_260 nsc-65238 3.989 µM 0.516412191639637 0.310913743810244 no 1040 0.302783276277528 1496 3246252
SGTC_860 0443-0016 25.1 µM 0.516281116320934 0.310958388474106 no 1041 0.302829041599523 1466 5337942
SGTC_1373 2887-0003 58.5 µM 0.516149304394908 0.311003286834687 no 1042 0.302875067233346 1465 776948
SGTC_3250 9135583 49.47 µM 0.5160751773833 0.311028537540816 no 1043 0.302900952023385 1517 7699353
SGTC_2932 9016711 44.54 µM 0.515646223586067 0.311174674296564 no 1044 0.303050760033901 1552 7117328
SGTC_1667 st014849 34.6 µM 0.510001575728163 0.31310046949772 no 1045 0.305025178932963 1490 5348460
SGTC_705 1124-0212 310 µM 0.509310092425539 0.313336736508412 no 1046 0.30526744241961 1541 9554485
SGTC_1886 st057356 49.9 µM 0.509077767703995 0.313416134756865 no 1047 0.305348857318621 1411 24207747
SGTC_1934 st074720 32.6 µM 0.508134950808991 0.313738436327262 no 1048 0.30567935290867 1430 17250992
SGTC_2386 9075165 157.42 µM 0.50798304196889 0.313790379610265 no 1049 0.305732617942966 1436 16452277
SGTC_609 0986-0026 86.3 µM 0.507808812709927 0.313849959619069 no 1050 0.305793714428313 1507 2848610
SGTC_593 1203-0218 61.7 µM 0.507149298052957 0.314075533367078 no 1051 0.306025033530909 1550 3666956
SGTC_186 3455-3465 67.277 µM 0.506411758836259 0.314327876146083 no 1052 0.306283810730936 1454 755278
SGTC_1744 st037937 38.9 µM 0.505930778086566 0.314492486390564 no 1053 0.306452622454306 1526 1016152
SGTC_3149 9097855 49.47 µM 0.505076134964051 0.314785069360854 no 1054 0.306752681283604 1594 25236625 YMR079W SEC14
SGTC_307 1501-1223 22.3 µM 0.503207614069176 0.315425153441544 no 1055 0.307409156062208 1457 2830329
SGTC_2075 5212009 200 µM 0.501486880241549 0.316015101676611 no 1056 0.308014254480089 1513 780898
SGTC_1784 st039334 36.3 µM 0.501144987206798 0.316132374517012 no 1057 0.308134543885942 1563 3496984
SGTC_647 0140-0236 81 µM 0.498101328312183 0.317177195279851 no 1058 0.309206312187538 1520 990837
SGTC_2476 5806916 10.51 µM 0.497999607044799 0.317212139179873 no 1059 0.309242159576507 1516 2870194
SGTC_801 0866-0028 10.1 µM 0.497218127044832 0.317480652212793 no 1060 0.309517619930628 1488 6849771
SGTC_465 cgp-37157 41 µM 0.496900329460504 0.317589873525921 no 1061 0.309629669592016 1495 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2316 5844804 197.44 µM 0.494924371261908 0.318269330817256 no 1062 0.310326753325751 1552 776813
SGTC_3088 9117578 49.47 µM 0.494909362769372 0.318274494014434 no 1063 0.310332050673783 1512 678341
SGTC_2326 6164455 177.58 µM 0.49328850610347 0.318832306104404 no 1064 0.310904374293494 1495 2888790
SGTC_3286 9117135 37.221 µM 0.491368786177354 0.319493502136516 no 1065 0.311582818459209 1429 3438150
SGTC_1505 k297-0037 20.6 µM 0.491024121296717 0.319612273578831 no 1066 0.311704693598161 1462 4089396
SGTC_833 3852-0053 558 µM 0.488354599600513 0.320532816080436 no 1067 0.312649346916748 1568 3123681
SGTC_2872 9044037 25.97 µM 0.487512334507612 0.320823487535904 no 1068 0.312947651994002 1573 6465195
SGTC_2260 7964312 200 µM 0.484219126533393 0.321961049483679 no 1069 0.314115182133212 1599 231951
SGTC_971 1315-0384 26.7 µM 0.483316649592488 0.322273081162919 no 1070 0.31443545998173 1477 6769120
SGTC_1356 1502-0781 85.8 µM 0.483192714886895 0.322315941413779 no 1071 0.314479453784659 1492 567702
SGTC_585 0kpi-0023 191 µM 0.480599868016081 0.323213164757385 no 1072 0.315400454638034 1572 64601
SGTC_2382 9035899 200 µM 0.479314389229646 0.32365837118361 no 1073 0.315857493541647 1514 6462679
SGTC_2425 5628681 7.85 µM 0.479181003824974 0.323704581701004 no 1074 0.315904933506136 1584 5714958
SGTC_645 0845-0943 5.41 µM 0.47887814728965 0.323809514495553 no 1075 0.316012658972136 1498 1885106
SGTC_3072 9116419 49.47 µM 0.478429000928568 0.323965159122228 no 1076 0.31617244820371 1461 17170162
SGTC_2269 7935389 174.42 µM 0.478382275156706 0.323981352973715 no 1077 0.316189073432728 1449 97605
SGTC_3135 9127742 49.47 µM 0.477537219029756 0.32427428336305 no 1078 0.316489812117715 1492 3643468
SGTC_2896 9052656 71.43 µM 0.475510609642479 0.324977230618317 no 1079 0.31721153643726 1482 6469436
SGTC_597 k018-0003 82.8 µM 0.475101455668933 0.325119224997516 no 1080 0.317357330500131 1611 6786234
SGTC_455 paf C-16 10 µM 0.473029591255066 0.325838642471136 no 1081 0.318096033859188 1521 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_12 0849-0099 9.267 µM 0.47293297947315 0.325872205022909 no 1082 0.318130497556498 1566 6071388
SGTC_2267 7931562 200 µM 0.4724290760231 0.326047281961369 no 1083 0.318310277301713 1421 934880
SGTC_2723 salbutamol 83.58 µM 0.472014378092494 0.326191393978346 no 1084 0.318458262929369 1544 9884233 β2-adrenoceptor agonist
SGTC_621 3584-0052 32.1 µM 0.471870505802072 0.326241397221728 no 1085 0.318509610758825 1577 2273927
SGTC_2568 diosmetin 100 µM 0.469979800689435 0.326898807384675 no 1086 0.319184724522093 1529 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2876 9059903 25.97 µM 0.468839645292393 0.327295506660139 no 1087 0.31959212982731 1509 6916095
SGTC_1070 indatraline 8.81 µM 0.467727161245379 0.327682766232452 no 1088 0.319989857458719 1498 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1564 D-Arginine 115 µM 0.463193351681113 0.329262915196297 no 1089 0.321612890619657 1439 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3002 9075603 71.4286 µM 0.46114101010299 0.329979215055564 no 1090 0.322348720337801 1522 20105405
SGTC_3206 9114350 49.47 µM 0.459992110333443 0.3303804718841 no 1091 0.322760941780213 1501 17087243
SGTC_328 k915-0120 63.5 µM 0.459757847260878 0.330462312954546 no 1092 0.322845021356952 1612 6624543
SGTC_2664 lyso-paf C-16 73.48 µM 0.458711775903322 0.330827862537224 no 1093 0.323220578255253 1542 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3247 9135149 49.47 µM 0.457668617351258 0.331192554953577 no 1094 0.323595268908807 1538 8934436 YOR116C RPO31
SGTC_648 0375-0473 33.3 µM 0.455973742780015 0.331785431345451 no 1095 0.324204429905169 1567 1713139
SGTC_1629 st005085 44.9 µM 0.455628135316362 0.331906378516825 no 1096 0.324328703786172 1491 24207091
SGTC_39 0986-0283 58.349 µM 0.455020307220901 0.332119133687325 no 1097 0.324547314696743 1688 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1775 st081588 35.1725 µM 0.454022326793195 0.332468569388354 no 1098 0.324906378567152 1537 1426443 YGL099W LSG1
SGTC_1371 2421-0008 32.7 µM 0.453380601979643 0.332693341697334 no 1099 0.325137351034915 1556 2827552
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.452959265945102 0.332840952741668 no 1100 0.325289036741982 1541 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1219 1469-0211 33.1 µM 0.452237317207057 0.333093940796414 no 1101 0.32554901369353 1595 6822282
SGTC_2019 4016004 108 µM 0.451440143729945 0.33337337765674 no 1102 0.325836178027544 1499 45595336
SGTC_3244 9134489 49.47 µM 0.450728552880144 0.333622892992024 no 1103 0.326092600406442 1495 16584271
SGTC_1150 3909-7983 10.9 µM 0.450159845774539 0.333822359874083 no 1104 0.326297593649193 1517 23965914
SGTC_3130 9127414 49.47 µM 0.449165278599774 0.334171304698284 no 1105 0.326656216351123 1543 1494646
SGTC_3112 9123419 49.47 µM 0.448055077773825 0.334560989048708 no 1106 0.327056723686548 1565 17015854
SGTC_1964 st076914 61 µM 0.446574668341989 0.335080895246435 no 1107 0.327591094533328 1559 24208661
SGTC_1360 1598-0022 39.8 µM 0.446035575117672 0.335270298413841 no 1108 0.327785774271515 1640 761525
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.445943380401618 0.33530269398492 no 1109 0.327819072725821 1638 6710655
SGTC_1439 4092-1168 46 µM 0.445912270338573 0.33531362577997 no 1110 0.32783030922114 1575 2886240
SGTC_2140 5586273 200 µM 0.44429908485208 0.335880675499717 no 1111 0.328413181399358 1552 854421
SGTC_2046 4110841 106 µM 0.442072067883266 0.336664106761746 no 1112 0.329218528092968 1596 44119630 YMR134W ERG29
SGTC_3028 9087778 49.47 µM 0.439153958650895 0.337691727431919 no 1113 0.330274991742019 1495 17217395
SGTC_1684 st024538 14.6195 µM 0.436895370278148 0.338487927986106 no 1114 0.331093614835798 1555 6732859
SGTC_2731 amoxapine 43.43 µM 0.436784594170504 0.338526997542173 no 1115 0.331133786344172 1660 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1854 st056233 32.9 µM 0.436064782512262 0.338780909787464 no 1116 0.331394863971819 1685 5393174
SGTC_3089 9117425 49.47 µM 0.435247586764448 0.339069262911521 no 1117 0.331691362409202 1505 9401657
SGTC_367 0335-0881 7.1 µM 0.435195977012054 0.339087476934114 no 1118 0.331710091221852 1643 23828853
SGTC_742 0kpi-0133 140 µM 0.434443342051356 0.339353138249611 no 1119 0.331983264881754 1684 2728852
SGTC_3097 9117246 49.47 µM 0.434129801725789 0.339463833715407 no 1120 0.332097092710453 1553 16423892
SGTC_586 0957-0265 8.15 µM 0.433094050291703 0.339829604355279 no 1121 0.332473222490996 1550 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3275 9138069 49.47 µM 0.432666304046804 0.339980704920058 no 1122 0.332628606413022 1617 17617007
SGTC_1857 st056007 79.3 µM 0.432156537506204 0.340160812576264 no 1123 0.332813822743706 1587 619834
SGTC_932 2857-0803 154 µM 0.431008731507994 0.340566481986698 no 1124 0.333231010847538 1687 674898
SGTC_308 4092-1169 104 µM 0.429417691769692 0.341129108704611 no 1125 0.333809640524419 1592 2268590 YDL196W YDL196W
SGTC_271 rotenone 740 µM 0.428389877930305 0.341492754314857 no 1126 0.334183646412967 1623 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_756 0508-1999 28.3 µM 0.426779424524822 0.342062836589399 no 1127 0.334769997126697 1502 6753853
SGTC_1383 3049-0032 20.7 µM 0.42570499765339 0.342443371955541 no 1128 0.335161409971385 1696 712864
SGTC_167 3672-0051 66.205 µM 0.425666794246543 0.342456905603147 no 1129 0.335175330740722 1526 3237971
SGTC_1907 st060210 83.7 µM 0.424443597202881 0.342890332899911 no 1130 0.335621165636094 1665 688793
SGTC_110 0850-0284 111.64 µM 0.423793475704499 0.343120780993018 no 1131 0.335858218329597 1513 3906265
SGTC_873 0591-4978 488 µM 0.422924869960873 0.343428766099816 no 1132 0.336175038484747 1738 3305145
SGTC_781 4335-2806 94.4 µM 0.422894604293204 0.343439499397956 no 1133 0.336186079854818 1718 845254
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.419848527015726 0.344520392838479 no 1134 0.33729805603507 1548 4174840
SGTC_2120 5538279 151.968 µM 0.419609310448902 0.344605332212666 no 1135 0.337385442863006 1617 2058197
SGTC_3293 9120939 62.045 µM 0.419500960818193 0.344643806833146 no 1136 0.337425026329969 1650 934087
SGTC_2128 5255449 168.493 µM 0.419353221201447 0.34469627130604 no 1137 0.337479003074754 1556 736008
SGTC_1764 st044502 93.5 µM 0.419200525587591 0.34475049886417 no 1138 0.337534794010011 1581 8407
SGTC_2749 bexarotene 57.39 µM 0.419002645072005 0.344820777908009 no 1139 0.337607099624959 1541 82146 An retinoic acid receptor inhibitor.
SGTC_73 0327-0325 16.231 µM 0.418602006265755 0.344963084775316 no 1140 0.337753511550401 1742 53298
SGTC_578 3460-0051 92 µM 0.416751140037943 0.345620796722984 no 1141 0.338430222029572 1693 2876744
SGTC_1144 3486-0183 12.5 µM 0.414941339856337 0.346264366648564 no 1142 0.339092422958263 1604 6744069
SGTC_2211 7117706 200 µM 0.414922149449427 0.346271193193148 no 1143 0.33909944734423 1670 822771
SGTC_1605 st000082 49.1 µM 0.412865454837153 0.347003103964649 no 1144 0.339852596053195 1656 1114022
SGTC_2925 9010536 32.5 µM 0.411959412506136 0.347325716383126 no 1145 0.340184586255919 1677 2994177
SGTC_3175 9106517 49.47 µM 0.411517224214211 0.347483205548106 no 1146 0.340346657015891 1570 41468073
SGTC_1367 1812-0510 76.9 µM 0.410966724830646 0.347679307433645 no 1147 0.340548467147306 1635 1142582 YDR527W RBA50
SGTC_306 1672-3436 11.6 µM 0.409987767372651 0.348028137656904 no 1148 0.340907460486969 1653 6797378
SGTC_726 3448-4391 34.2 µM 0.409815252871212 0.348089622792197 no 1149 0.340970738197385 1731 1356692
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.409770361634115 0.348105622935602 no 1150 0.340987204878371 1636 688788
SGTC_2566 crystal violet carbinol 226 nM 0.409687939603068 0.348135000515813 no 1151 0.341017439124097 1509 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2133 5320837 200 µM 0.408178146465638 0.348673295259786 no 1152 0.341571445500372 1665 2841355
SGTC_2272 7805186 180 µM 0.407753775979752 0.348824653297561 no 1153 0.341727226349914 1654 2956062 YPR165W RHO1
SGTC_2076 5212012 200 µM 0.407682701053331 0.348850005578921 no 1154 0.341753319661174 1606 604802
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.407606307661336 0.348877255698593 no 1155 0.341781366351859 1661 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_215 1287-0124 461.5 µM 0.407245706499211 0.349005895471784 no 1156 0.341913767460934 1714 5560863
SGTC_419 nsc-638432 893 µM 0.407063299238311 0.349070973499702 no 1157 0.341980748927014 1609 368090
SGTC_1700 st030840 7.9285 µM 0.406457363367367 0.349287187054307 no 1158 0.342203289320172 1734 5499307
SGTC_1260 0700-1617 7.75 µM 0.406402666512562 0.349306706711831 no 1159 0.342223380381316 1637 2853078
SGTC_1825 st052143 62.6 µM 0.406114481356056 0.349409557882299 no 1160 0.342329242939044 1677 674173
SGTC_2738 aclarubicin 5.55 µM 0.405846755906626 0.349505117041703 no 1161 0.342427600886153 1666 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.403758260431347 0.350250890067115 no 1162 0.343195246354622 1611 6708784 An antioxidant flavonoid
SGTC_2147 5545932 89.7195 µM 0.403364564835625 0.350391538163336 no 1163 0.34334002537253 1631 797404
SGTC_1289 0976-0073 69.1 µM 0.40239604325191 0.350737630632139 no 1164 0.343696290763252 1654 3391136
SGTC_1513 0337-0559 19 µM 0.402344339485068 0.350756109994055 no 1165 0.343715313619559 1548 775073
SGTC_2786 7743617 45.45 µM 0.40094972093528 0.351254691495692 no 1166 0.344228571005455 1523 583674
SGTC_3063 1327-0034 4 µM 0.399770205349173 0.351676572805454 no 1167 0.344662888786695 1635 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2377 9073351 62.6 µM 0.39905075351264 0.351933991322174 no 1168 0.344927903849998 1589 7337946 YHR072W ERG7
SGTC_327 1273-0057 3.96 µM 0.397940993112885 0.352331194585471 no 1169 0.34533684095145 1634 3108138
SGTC_1295 1013-0063 9.78 µM 0.39599281454578 0.353028872300894 no 1170 0.346055164519273 1753 6826038
SGTC_998 3996-0085 177 µM 0.394325663628466 0.35362630165268 no 1171 0.34667030912282 1763 715391
SGTC_1992 st073643 23.3 µM 0.3938917201756 0.353781866029654 no 1172 0.346830491794554 1634 3161292
SGTC_2902 5787006 60.46 µM 0.389786294332054 0.35525482506345 no 1173 0.348347289657872 1611 591003
SGTC_1807 st050092 58.9 µM 0.387900805249916 0.355932034354287 no 1174 0.349044721097348 1619 5008496
SGTC_2385 9074692 200 µM 0.385687941134248 0.356727406679358 no 1175 0.349863897366149 1614 17046906
SGTC_859 0439-0102 54.6 µM 0.385645152063059 0.356742792559046 no 1176 0.349879744281211 1758 610143
SGTC_2951 9072950 58.06 µM 0.385315424101589 0.35686136230269 no 1177 0.350001867666929 1673 16488155
SGTC_744 1594-0068 283 µM 0.384430201011994 0.357179755743531 no 1178 0.350329809937959 1644 668392
SGTC_315 k915-0449 187 µM 0.384238333300502 0.357248779066155 no 1179 0.350400904523626 1707 20970215 YNL149C PGA2
SGTC_1789 tunicamycin 25 nM 0.383960090655289 0.357348883580583 no 1180 0.350504013754397 1703 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_203 k066-0004 30.888 µM 0.381146827908644 0.358361573218465 no 1181 0.351547150776293 1738 6795412
SGTC_421 streptovitacin 30 mM 0.380879539113022 0.35845784108745 no 1182 0.351646317810902 1646 91467 include heat shock
SGTC_319 1348-1596 45.5 µM 0.380607885060804 0.35855569038336 no 1183 0.35174711474777 1772 5380505
SGTC_2827 7993847 71.43 µM 0.379247388196588 0.359045878479123 no 1184 0.352252082287583 1681 2985692
SGTC_642 0335-0876 158 µM 0.378501738746915 0.35931463511295 no 1185 0.352528951174774 1672 6812350
SGTC_1570 verbenone 133 µM 0.37793766786753 0.359517991109595 no 1186 0.352738449616175 1796 29025 A natural terpanoid with antifungal properties.
SGTC_2181 6316240 54.2555 µM 0.377684165256029 0.359609395559215 no 1187 0.352832616168241 1591 12779990
SGTC_2985 9022375 71.43 µM 0.376888389280548 0.359896377563843 no 1188 0.353128275145135 1650 4939335
SGTC_1951 sophoraflavanone G 9.2 µM 0.376250904207626 0.360126331858921 no 1189 0.353365187429526 1623 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1275 0867-0008 21.1 µM 0.375835352445486 0.3602762573933 no 1190 0.353519651949831 1684 3422836
SGTC_1062 mesoridazine 14.2 µM 0.375371952727309 0.36044347117518 no 1191 0.35369193045976 1672 4078 A neuroleptic.
SGTC_581 0958-0271 211 µM 0.373805107501278 0.361009051279236 no 1192 0.354274659646686 1606 4591145
SGTC_423 5-fluorouracil 457 µM 0.373274529449057 0.361200641649063 no 1193 0.354472065649412 1568 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.373034491522166 0.361287330170158 no 1194 0.354561386617019 1655 5106787 A p450 inhibitor.
SGTC_349 k015-0014 24 µM 0.372991978857505 0.361302684153299 no 1195 0.354577206919043 1621 2196908
SGTC_2227 7312221 64.1025 µM 0.372752993377427 0.36138900092035 no 1196 0.354666145614435 1717 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1607 st000305 50.6 µM 0.37214499048343 0.361608631185047 no 1197 0.35489245023483 1716 5457690
SGTC_344 k064-0035 6.43 µM 0.370655070071378 0.36214703118409 no 1198 0.355447229535715 1611 5088750
SGTC_427 1354-0053 47.3 µM 0.368841726886403 0.362802671817014 no 1199 0.356122850282732 1753 6813657
SGTC_2678 equilin 100 µM 0.367757629709554 0.363194835274391 no 1200 0.356526982430322 1776 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1180 1193-0155 285 µM 0.367547298234262 0.363270937627837 no 1201 0.356605408942687 1643 2921347
SGTC_1707 st032323 6.317 µM 0.367429256845202 0.363313649851014 no 1202 0.356649425812573 1701 3132057 YMR211W DML1
SGTC_2531 methyl deoxycholate 70.07 µM 0.366375301913266 0.36369508931478 no 1203 0.357042523344747 1619 16667744 Haematoxylin.
SGTC_354 2783-3500 4.88 µM 0.365937481820929 0.363853581630014 no 1204 0.357205863404889 1611 6740761
SGTC_293 4049-0273 38.5 µM 0.3642011078263 0.364482383903751 no 1205 0.357853919895624 1688 1380311
SGTC_249 wiskostatin 11.211 µM 0.364095776142756 0.364520539976014 no 1206 0.357893245416125 1764 2775510 A n-wasp and actin depolymerizer.
SGTC_979 1426-2828 121 µM 0.364058925231779 0.364533889420014 no 1207 0.357907004037651 1762 747872
SGTC_3356 9151811 4.48 µM 0.363906171192655 0.364589227157726 no 1208 0.357964038110508 1660 1859254 YPR165W RHO1
SGTC_1023 4482-3888 16 µM 0.363156437244725 0.364860871871446 no 1209 0.358244013680518 1781 3303168
SGTC_2680 butyl paraben 22.24 µM 0.362603437332789 0.365061279106136 no 1210 0.358450571087476 1695 7184 An antifungal and steroid mimetic.
SGTC_3138 9097216 49.47 µM 0.362127263573715 0.365233874073758 no 1211 0.358628465460233 1710 25237486
SGTC_577 r071-0003 38.6 µM 0.362021792619109 0.365272106997806 no 1212 0.358667872642379 1639 4568517 YMR134W ERG29
SGTC_2543 pimpinellin 60.67 µM 0.3612775697066 0.365541923748173 no 1213 0.358945979885059 1632 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3122 9126309 49.47 µM 0.360316392739936 0.365890495281527 no 1214 0.359305270920217 1756 17591206
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.359984590068696 0.366010849490004 no 1215 0.359429328734734 1795 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_980 1473-0395 201 µM 0.359177406519137 0.366303692815886 no 1216 0.35973118872008 1657 768876
SGTC_2093 5331342 194.4 µM 0.356215311509925 0.367378996439656 no 1217 0.360839663054891 1781 33839
SGTC_228 caffeine 993.056 µM 0.355876814427631 0.367501944518737 no 1218 0.360966409999426 1764 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1092 toremifene 6.32 µM 0.353757793355506 0.368271918347147 no 1219 0.361760203336239 1709 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2205 7238770 200 µM 0.353533606999479 0.368353410390815 no 1220 0.361844219270704 1774 279867
SGTC_1697 st025554 27.742 µM 0.352217087604938 0.368832086374545 no 1221 0.362337731485007 1673 1269519
SGTC_2773 thioridazine 9.09 µM 0.351943189502364 0.368931699150233 no 1222 0.362440434081701 1726 5452 An antipsychotic.
SGTC_2437 5741531 144.16 µM 0.349865349931567 0.369687665641702 no 1223 0.363219876153224 1817 2262990
SGTC_1938 st074717 56.4 µM 0.348866490866814 0.37005125341203 no 1224 0.363594771476661 1663 17250979
SGTC_1492 4158-0558 28.5 µM 0.348798728530355 0.370075923322145 no 1225 0.363620209013285 1805 3967268
SGTC_2180 6301957 200 µM 0.348445759149969 0.370204435840558 no 1226 0.363752721123598 1800 845462
SGTC_3031 9088762 49.47 µM 0.345435146637863 0.371301156435179 no 1227 0.364883629119345 1660 205253
SGTC_2458 5808907 16.39 µM 0.345043452032628 0.371443921927891 no 1228 0.365030852177948 1827 2731747
SGTC_3257 9139206 32.98 µM 0.34453834959432 0.371628048601986 no 1229 0.365220730286362 1775 4910041
SGTC_17 0960-0276 49.807 µM 0.344236151848643 0.371738223799394 no 1230 0.365334348265897 1726 6821114
SGTC_1262 0737-0114 49.6 µM 0.344062807928043 0.371801426235549 no 1231 0.36539952611248 1833 765919
SGTC_1597 7-benzyloxygramine 47.5 µM 0.343137300773703 0.372138931212155 no 1232 0.365747585388573 1677 260807
SGTC_2035 5154463 94.595 µM 0.342324352102666 0.37243547051804 no 1233 0.366053405545005 1806 2769623
SGTC_2762 leflunomide 42.06 µM 0.341970205538521 0.372564676233175 no 1234 0.366186657259863 1723 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.340968045132824 0.372930378947179 no 1235 0.366563819033201 1629 641818 YHR062C RPP1
SGTC_2514 salinomycin 42.74 µM 0.34009587107214 0.373248741011458 no 1236 0.36689216553096 1871 23682228 A polyether potassium ionophore.
SGTC_1554 st069299 38.7 µM 0.337097594085007 0.374343834794929 no 1237 0.368021665520386 1783 24207999
SGTC_1773 st048542 73.5835 µM 0.336519360057084 0.374555146557188 no 1238 0.368239627394619 1645 3237138
SGTC_1643 st009866 20.2 µM 0.333778384670608 0.375557329350699 no 1239 0.369273397734635 1810 3156273 YOR207C RET1
SGTC_25 0118-0223 35.662 µM 0.3335419195867 0.375643827544077 no 1240 0.369362625965269 1779 5333628
SGTC_888 0916-0002 6.97 µM 0.333457071945327 0.37567486607183 no 1241 0.369394644268119 1809 2802138 YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 0.332151786436649 0.376152460186912 no 1242 0.36988732387889 1715 101795 A weak amylase inhibitor.
SGTC_1805 st050013 60.3 µM 0.332036819666385 0.376194534761986 no 1243 0.369930728299167 1783 4037144
SGTC_2356 9061756 188.97 µM 0.330104623960437 0.376901883363869 no 1244 0.370660454738729 1861 20104043
SGTC_1421 4029-0249 71.4 µM 0.329588821044343 0.377090781273888 no 1245 0.370855335282287 1872 2894095
SGTC_2605 digitonin 300 nM 0.328571211429084 0.377463537616185 no 1246 0.371239905441608 1874 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1228 0124-0032 52.5 µM 0.326760222249836 0.378127195731192 no 1247 0.371924623675783 1810 X1228
SGTC_2338 7999974 200 µM 0.326438647325534 0.378245078283785 no 1248 0.372046250608371 1917 315925
SGTC_902 1120-0002 2.07 µM 0.325748402628534 0.378498145624151 no 1249 0.372307359916201 1696 3280475
SGTC_1408 3909-7976 48.8 µM 0.325545786557397 0.378572441513237 no 1250 0.372384017716347 1768 24152374
SGTC_53 0973-0023 39.979 µM 0.324964813473757 0.378785499402123 no 1251 0.372603851202195 1922 674768
SGTC_1071 trifluoperazine 6.31 µM 0.324945301493836 0.378792655590712 no 1252 0.3726112350302 1819 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1610 st001799 48.1 µM 0.324202529155205 0.379065104694183 no 1253 0.372892353708376 1674 621897
SGTC_97 0535-0701 19.132 µM 0.323549692379648 0.379304615029633 no 1254 0.373139490184884 1664 2832013 YGL099W LSG1
SGTC_1942 st076330 65.2 µM 0.322884801296286 0.379548595429815 no 1255 0.373391243575274 1784 24208414
SGTC_2596 sinensetin 100 µM 0.322670628801863 0.379627195800284 no 1256 0.373472349051034 1704 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1036 k216-0215 33.5 µM 0.321726373644521 0.379973792590678 no 1257 0.373829998001429 1691 622330
SGTC_3110 9122132 49.47 µM 0.321614219986659 0.380014965945295 no 1258 0.373872484886962 1844 918317
SGTC_724 3910-0327 137 µM 0.320827450046964 0.380303839652534 no 1259 0.374170578004081 1700 2885483
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.320804806713348 0.380312154461888 no 1260 0.374179158274752 1783 6708739 YPR165W RHO1
SGTC_2964 9083345 53.42 µM 0.320351526277303 0.380478614216378 no 1261 0.374350933583232 1686 17741579
SGTC_1968 st069590 43.6 µM 0.318825563268519 0.381039161444508 no 1262 0.374929396204653 1832 6384066
SGTC_794 k038-0031 316 µM 0.317302419066255 0.381598922267923 no 1263 0.375507070992834 1725 6624242
SGTC_834 0312-0008 75.7 µM 0.3168407962756 0.381768619225872 no 1264 0.375682203407626 1742 6385573 YIL048W NEO1
SGTC_1814 st052110 31.539 µM 0.316825972182583 0.381774069081154 no 1265 0.375687827859698 1863 674163
SGTC_813 k007-0158 173 µM 0.316758751871381 0.381798781913594 no 1266 0.375713332444144 1838 6523916
SGTC_2436 5633522 8.09 µM 0.316403246041216 0.381929487859439 no 1267 0.375848226722266 1890 5724242
SGTC_2936 9038235 15.59 µM 0.316345210657304 0.381950826536829 no 1268 0.37587024929658 1730 4749415
SGTC_309 k408-0051 1.48 µM 0.316296426391404 0.381968764004344 no 1269 0.375888761679911 1760 3640463
SGTC_892 0929-0076 29 µM 0.313777617354256 0.382895247357535 no 1270 0.376844972613547 1744 5751038
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.312897199309928 0.383219246366756 no 1271 0.377179382724543 1806 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1206 3978-0017 132 µM 0.312150129124098 0.383494236670323 no 1272 0.377463215448113 1837 3873677
SGTC_1982 st072467 71.9 µM 0.311748749624967 0.383642005365233 no 1273 0.377615738019778 1727 3163533
SGTC_3082 9117008 49.47 µM 0.311252085150634 0.383824876846826 no 1274 0.377804494911268 1759 41448529
SGTC_1277 0873-0036 22 µM 0.31038142118021 0.384145517073349 no 1275 0.378135460370184 1841 5965735
SGTC_342 k048-0088 23.3 µM 0.309906978192719 0.384320274028901 no 1276 0.378315848030598 1721 6820570
SGTC_270 tamoxifen 5.46 µM 0.308835949983455 0.384714864385887 no 1277 0.378723160439917 1899 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_10 0279-0212 42.575 µM 0.30754891701349 0.385189193642044 no 1278 0.379212797753783 1733 39851 YBR002C RER2
SGTC_1392 3455-1037 33.9 µM 0.307286384933791 0.385285969586505 no 1279 0.379312698978107 1852 981132
SGTC_3128 9127691 49.47 µM 0.307020929329383 0.38538383047982 no 1280 0.379413720884799 1785 41316314
SGTC_1788 fluconazole 20 µM 0.306358925692747 0.38562791161073 no 1281 0.379665689148973 1733 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2030 5175110 200 µM 0.305924800879201 0.385787998284019 no 1282 0.379830951153547 1822 2831986
SGTC_2532 xanthone 78.9 µM 0.305877969545675 0.38580526884087 no 1283 0.379848780149831 1835 7020 An insecticide.
SGTC_351 caspofungin 25 nM 0.305170933106844 0.3860660387017 no 1284 0.380117984580793 1822 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_629 3448-6466 76.7 µM 0.30466559470988 0.386252449651795 no 1285 0.380310427999393 1774 573744
SGTC_2086 5274770 176.623 µM 0.304417759626799 0.386343881501807 no 1286 0.380404819608752 1761 689278
SGTC_1461 k072-0203 53.8 µM 0.304399009768912 0.386350798996427 no 1287 0.380411961055685 1766 5418714
SGTC_2244 6635614 200 µM 0.303125854230982 0.386820596099112 no 1288 0.38089697583885 1775 836499
SGTC_674 0498-0004 451 µM 0.302690093122556 0.386981431016043 no 1289 0.381063024189694 1733 4231473
SGTC_1088 bifonazole 369 nM 0.302512778841778 0.387046881439616 no 1290 0.381130596710722 1776 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_116 0155-0182 31.788 µM 0.302396470517657 0.387089815028259 no 1291 0.381174922501747 1747 771486
SGTC_1512 0259-0544 12.2 µM 0.301983747733841 0.387242177007578 no 1292 0.381332226176509 1818 18476
SGTC_984 1492-0255 2.91 µM 0.301943870197362 0.387256899239131 no 1293 0.381347425996204 1795 1585198
SGTC_1514 1189-1591 158 µM 0.301551625778249 0.387401719059514 no 1294 0.381496944592179 1851 767698 YMR146C TIF34
SGTC_1723 st034307 2.5525 µM 0.301242896522493 0.387515715426176 no 1295 0.381614640707232 1735 867466
SGTC_1329 1447-1697 50.6 µM 0.300626848863376 0.387743216186802 no 1296 0.381849527786017 1795 2840515
SGTC_2760 etidronate 98.04 µM 0.300093919385869 0.387940053260353 no 1297 0.382052758606314 1746 3305 A chelator and antioxidant.
SGTC_2706 st078239 82.5 µM 0.297707976165107 0.38882165184899 no 1298 0.382963027613432 1787 15434492
SGTC_1326 1431-2094 10.8 µM 0.297018648805939 0.389076463020371 no 1299 0.3832261357884 1728 616278
SGTC_660 4031-1742 102 µM 0.294211315590812 0.390114690870128 no 1300 0.384298217257684 1778 6738706
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.292275573235788 0.390831038152672 no 1301 0.385037966778226 1851 616764
SGTC_2780 5215298 71.43 µM 0.291882713283169 0.390976466538889 no 1302 0.385188150527813 1949 2834131
SGTC_2792 7535235 81.82 µM 0.289642814788521 0.391805919964936 no 1303 0.386044754422524 1711 1281891
SGTC_472 calcifediol 10 µM 0.289425499997759 0.391886419720469 no 1304 0.386127891717862 1819 5283731 A vitamin D metabolite.
SGTC_2873 9040596 71.43 µM 0.289384493134789 0.391901610381278 no 1305 0.386143580144488 1741 6463863
SGTC_1118 chelidonine 707.474 nM 0.289112381456963 0.392002416125834 no 1306 0.386247689484903 1939 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2892 9047358 58.44 µM 0.288003223579123 0.392413386639181 no 1307 0.386672135555228 1785 6466771
SGTC_2459 5811157 9.22 µM 0.287882198602869 0.392458236665735 no 1308 0.386718456901777 1841 2870684 YBR192W RIM2
SGTC_2702 st077768 96.8 µM 0.287119844558118 0.392740786363191 no 1309 0.387010278922777 1757 6484119
SGTC_32 0928-0142 34.1 µM 0.284894154880458 0.393566012052761 no 1310 0.387862617116782 1890 2244242
SGTC_1041 0206-0046 107 µM 0.284830633274736 0.393589571188172 no 1311 0.387886950963992 1793 50494
SGTC_1900 st060200 72.8 µM 0.282408999959779 0.39448800553875 no 1312 0.388814957389632 1775 688945
SGTC_776 4476-4378 112 µM 0.282268599592221 0.39454011182991 no 1313 0.388868780448382 1795 2892008
SGTC_1335 1486-0900 202 µM 0.281215009386438 0.394931187179416 no 1314 0.38927274658591 1798 X1335
SGTC_765 1319-0117 244 µM 0.28057905813805 0.395167293088046 no 1315 0.389516640118057 1748 3487746 YGL099W LSG1
SGTC_332 4112-0506 40.9 µM 0.279287981390783 0.395646741934251 no 1316 0.390011914468347 1816 2790355
SGTC_3109 9122853 49.47 µM 0.278563170678351 0.39591597387939 no 1317 0.390290039910474 1869 1234709
SGTC_171 k064-0041 9.68 µM 0.278280727395923 0.396020901282662 no 1318 0.390398434679664 1746 53325
SGTC_13 0199-0087 65 µM 0.278132622878784 0.396075924977609 no 1319 0.390455276948028 1853 4589825
SGTC_55 0767-0285 6.563 µM 0.278059700131267 0.396103017950668 no 1320 0.390483265438097 1935 3116166
SGTC_1771 st048882 4.1505 µM 0.277749463874932 0.396218285569343 no 1321 0.390602343601067 1743 4580403
SGTC_392 N-ethylmaleimide 8.33 µM 0.277611663078636 0.396269488071789 no 1322 0.390655239052747 1776 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1494 4358-1428 177 µM 0.276408652907876 0.396716565247981 no 1323 0.391117105728005 1965 1564571
SGTC_1563 conessine 56.1 µM 0.27630952343251 0.396753411005691 no 1324 0.391155170952456 1960 441082 An anti-amoebic, histamine inhibitor.
SGTC_2214 7179297 48.276 µM 0.276077527368651 0.396839645981324 no 1325 0.391244260359444 1876 769744
SGTC_2817 7995342 71.43 µM 0.275795905375267 0.39694433412993 no 1326 0.391352414414968 1738 18879975
SGTC_955 1216-0110 33 µM 0.27427866604469 0.397508469455145 no 1327 0.391935239057531 1763 3619719
SGTC_2757 clomiphene 4.22 µM 0.271181130463619 0.398660850331129 no 1328 0.393125862557584 1958 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_413 propylparaben 100 µM 0.270712860364359 0.398835138744646 no 1329 0.393305942447588 1780 7175 A pharmaceutical preservative.
SGTC_1021 4476-0760 85.3 µM 0.267872431340177 0.399892767145547 no 1330 0.394398757513287 1759 746768
SGTC_1712 st032288 53.4 µM 0.26782506632079 0.399910409671359 no 1331 0.394416987611192 1837 2883011
SGTC_673 1082-0474 110 µM 0.26774149890332 0.399941537367213 no 1332 0.3944491520425 1776 3098046
SGTC_2968 9090663 33.37 µM 0.267663725373783 0.399970507491945 no 1333 0.394479087099194 1837 25236811
SGTC_1581 himbacine 57.9 µM 0.266685343556994 0.400334995215113 no 1334 0.39485571975076 1804 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2789 5281112 71.43 µM 0.264380085186023 0.401194142119456 no 1335 0.395743527739272 1770 765948
SGTC_2040 5100729 123 µM 0.262572517650608 0.40186813915517 no 1336 0.39644004235444 1876 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2053 5265679 138 µM 0.261714705680667 0.402188098211201 no 1337 0.396770701055203 1811 764595
SGTC_3026 9090633 49.47 µM 0.261085580514835 0.402422800051507 no 1338 0.397013255612281 1810 25236842
SGTC_3163 9099914 49.47 µM 0.260955433042852 0.402471357345562 no 1339 0.397063437984852 1933 16268368
SGTC_3303 9125618 40.5795 µM 0.260119728778659 0.402783189756473 no 1340 0.397385710118339 1907 22695467
SGTC_3232 9132874 49.47 µM 0.259216736740849 0.40312019926404 no 1341 0.397734009142431 1798 3784940
SGTC_1407 3909-7909 12.3 µM 0.25894728394172 0.403220776846064 no 1342 0.397837957368879 1850 4411780
SGTC_1664 st014217 9.02 µM 0.25892934085133 0.403227474619984 no 1343 0.397844879627081 1957 3982782
SGTC_783 0848-0141 92.7 µM 0.258648006492553 0.403332494461966 no 1344 0.397953419709261 1822 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1299 1079-1439 3.74 µM 0.258592222251826 0.403353319096605 no 1345 0.397974942463026 1819 323161
SGTC_997 3996-0078 137 µM 0.258526923404323 0.40337769594651 no 1346 0.398000136550102 1853 735687
SGTC_3195 9113082 49.47 µM 0.258353673897101 0.403442373903098 no 1347 0.398066983024649 2004 17018038
SGTC_3216 9129716 49.47 µM 0.258280929743351 0.40346953172713 no 1348 0.398095051472533 1805 8056934
SGTC_3101 9120531 49.47 µM 0.252358876588992 0.405681982282132 no 1349 0.400381841683391 1959 24824904
SGTC_2012 4023501 200 µM 0.251457825317458 0.406018876839598 no 1350 0.400730082655108 1815 3477460
SGTC_798 1287-0182 476 µM 0.250546681610815 0.40635961564349 no 1351 0.401082304422994 1988 1649755
SGTC_146 3448-8650 53.125 µM 0.25026617585455 0.406464530176684 no 1352 0.401190756026208 1879 2891488 YIL048W NEO1
SGTC_2271 7849410 118.62 µM 0.249452277453462 0.40676898177322 no 1353 0.401505475652802 2024 972430
SGTC_1375 2910-0797 186 µM 0.248335440992596 0.407186843842312 no 1354 0.401937439855446 1882 742508
SGTC_2315 7733312 200 µM 0.247096242177984 0.407650611173937 no 1355 0.402416870944671 1823 726316
SGTC_3290 9121031 71.43 µM 0.247051320130588 0.407667425583045 no 1356 0.402434253505416 1827 17014854
SGTC_2826 7992541 19.48 µM 0.245191697345833 0.408363634892174 no 1357 0.403154002386676 1943 2985066
SGTC_2846 9008642 19.48 µM 0.244402929598564 0.408659022863723 no 1358 0.403459386537255 1834 2992898
SGTC_27 0485-0001 32.618 µM 0.241965226616715 0.40957225280304 no 1359 0.404403553917421 1975 2054479
SGTC_405 ebelactone b 50 µM 0.241947140521651 0.40957903018743 no 1360 0.404410561084431 1867 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2711 st079103 59.1 µM 0.240707153626792 0.410043753568293 no 1361 0.404891047088619 1979 54693780
SGTC_1457 k015-0032 57.3 µM 0.239446707551239 0.410516274181342 no 1362 0.4053796078775 1859 4302660
SGTC_2843 9000894 45.46 µM 0.237765464814733 0.411146746689839 no 1363 0.406031502838764 1890 2242070
SGTC_1785 bathophenanthroline 24 µM 0.237030604947218 0.411422394171267 no 1364 0.406316523694803 1815 72812 An iron chelator.
SGTC_1487 3970-0795 2.82 µM 0.2368366168545 0.411495166813726 no 1365 0.406391771706207 1930 3765103
SGTC_608 k048-0125 159 µM 0.236607758388788 0.411581024633764 no 1366 0.406480550385801 1987 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2095 5432005 200 µM 0.233787778240818 0.412639305772257 no 1367 0.407574869114277 1894 783734
SGTC_2627 acetyl isogambogic acid 100 µM 0.233299553581414 0.412822591283675 no 1368 0.407764402616761 1815 6857789 A caspase activator and apoptosis inducer.
SGTC_1039 k821-0043 94 µM 0.233002836337626 0.412933991856447 no 1369 0.407879601651322 1985 15992768
SGTC_526 4469-0568 170 µM 0.23249661966996 0.413124063815892 no 1370 0.408076156203765 1823 2901964
SGTC_665 3914-0008 307 µM 0.229404912183121 0.414285364683734 no 1371 0.409277109295484 1857 1069549
SGTC_2536 dehydroabietamide 32.04 µM 0.227838700791223 0.414873948578157 no 1372 0.409885819476144 2003 3983547
SGTC_485 niflumic acid 177 µM 0.226632457577597 0.41532738641827 no 1373 0.410354775703254 1972 4488 A COX2 inhibitor.
SGTC_761 k216-0224 480 µM 0.22640077496875 0.415414490957889 no 1374 0.410444862619975 2052 1340404
SGTC_2537 larixol 68.93 µM 0.22377963633859 0.416400235763258 no 1375 0.411464388004506 1923 6708759
SGTC_772 k072-0172 35.3 µM 0.222871367628965 0.416741935985691 no 1376 0.411817810624549 1790 5861980
SGTC_2988 9073640 71.4286 µM 0.222811448136508 0.416764480542701 no 1377 0.411841128824955 1933 9102229
SGTC_903 1134-0042 114 µM 0.222644685814852 0.416827225884033 no 1378 0.41190602749589 1891 701009
SGTC_2419 paclitaxel 166.5 µM 0.222284741682375 0.416962664281035 no 1379 0.412046114686534 1901 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_57 miconazole 162.5 nM 0.220452448113771 0.417652265125632 no 1380 0.412759401129928 1846 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1171 0368-0077 21.4 µM 0.218849948449151 0.418255588621508 no 1381 0.41338346830817 1899 3239779
SGTC_1311 1190-0148 100 µM 0.217952958242157 0.418593379642444 no 1382 0.413732882069297 1999 1961333
SGTC_1148 3909-7663 27.7 µM 0.217687431673811 0.418693383890149 no 1383 0.413836328463705 2031 4084526
SGTC_1675 st018485 24.5 µM 0.217439076011121 0.418786925882007 no 1384 0.413933090663707 1899 3323024
SGTC_1236 0330-0013 258 µM 0.217397026296042 0.418802764164049 no 1385 0.413949474229931 1898 4617066
SGTC_2699 st077704 54.6 µM 0.217071570461966 0.418925353541461 no 1386 0.414076284604678 1930 645852
SGTC_905 2-aminofluorene 215 µM 0.216913556414261 0.418984875497763 no 1387 0.414137856315066 1941 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2080 5212524 12.4 µM 0.215825922452948 0.41939462413017 no 1388 0.414561720644355 2073 260183
SGTC_1174 0739-0097 51.1 µM 0.215476975900581 0.419526102686206 no 1389 0.414697730513941 1917 728447
SGTC_1382 3002-2117 298 µM 0.215025038776602 0.419696400111875 no 1390 0.414873898503249 2045 1497314
SGTC_1237 0330-0133 46.1 µM 0.21457944768355 0.419864320972577 no 1391 0.415047609530694 1901 X1237 YHR072W ERG7
SGTC_1995 st072814 61.1 µM 0.213450308108939 0.420289902125329 no 1392 0.415487872151969 1869 5769371
SGTC_2517 totarol 10 µM 0.213344331951785 0.420329850123929 no 1393 0.415529198753378 1866 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1198 1612-1005 86.7 µM 0.212303686704048 0.420722167693484 no 1394 0.415935059707946 2009 6998509
SGTC_2987 9018338 71.43 µM 0.209479182317764 0.421787386273588 no 1395 0.417037092493581 2012 5055682
SGTC_1314 1222-0010 41.1 µM 0.207462233623426 0.422548398453699 no 1396 0.417824442108773 1948 3526027
SGTC_1891 st059073 26.2 µM 0.206312570885986 0.42298230572613 no 1397 0.418273379807291 2074 688754
SGTC_3298 9116858 71.43 µM 0.204979138196067 0.42348568871952 no 1398 0.41879421213034 2008 2506942
SGTC_1530 rhein 70.4 µM 0.204668784703115 0.423602867940889 no 1399 0.418915455152993 2032 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_18 0111-0177 500 nM 0.20435383258851 0.423721790357232 no 1400 0.419038502551554 1948 721752
SGTC_3246 9135460 32.98 µM 0.20411003901237 0.423813848871702 no 1401 0.419133754740084 2004 41446951
SGTC_1777 st045864 34.765 µM 0.201727075098527 0.424713894379668 no 1402 0.420065047423659 2045 4691462
SGTC_2101 5377231 179.231 µM 0.201642557063031 0.424745824080815 no 1403 0.420098086402235 2011 2844213
SGTC_67 0335-0847 266 µM 0.201272521985195 0.424885623834595 no 1404 0.420242743586584 2087 4552207 YOR254C SEC63
SGTC_908 3448-7491 47.7 µM 0.200930010907015 0.425015033404117 no 1405 0.420376650462788 1928 1203031
SGTC_3160 9100216 49.47 µM 0.20004258031159 0.42535036526028 no 1406 0.420723639912046 2074 17191039
SGTC_1557 sumaresinolic acid 42.3 µM 0.199311215544363 0.425626765401838 no 1407 0.421009653221555 1916 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3189 9110682 49.47 µM 0.199078814174833 0.42571460306628 no 1408 0.421100546681937 1926 17122418
SGTC_1014 4130-3005 69.3 µM 0.1988756368172 0.425791398338834 no 1409 0.421180013915284 1899 743608
SGTC_2006 4011487 200 µM 0.198720142458116 0.425850172693333 no 1410 0.42124083342496 2022 45595294
SGTC_1004 4084-0029 199 µM 0.197328607678572 0.426376223535609 no 1411 0.421785196878914 2065 716894 YLR208W SEC13
SGTC_93 0109-0045 59.227 µM 0.195923077067915 0.426907698309865 no 1412 0.422335187208787 2076 88733
SGTC_1651 st011928 86.1 µM 0.193581475471157 0.427793424877345 no 1413 0.42325180211984 2005 720198
SGTC_2051 5263410 176 µM 0.193476391193654 0.427833182279842 no 1414 0.423292946914131 2085 227584
SGTC_433 pimozide 108 µM 0.193462901289743 0.427838286079665 no 1415 0.423298228824064 1806 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2111 5486399 200 µM 0.193062898425581 0.42798962952363 no 1416 0.423454854369185 1964 689674
SGTC_2994 9053520 71.4286 µM 0.193018351258514 0.428006484863165 no 1417 0.423472298054101 2037 4647384
SGTC_876 0720-0963 56.8 µM 0.192228633609146 0.428305312603922 no 1418 0.423781558878441 2100 765861
SGTC_1285 0929-0069 65.5 µM 0.191182696988591 0.428701156406017 no 1419 0.424191229691579 1956 1206237
SGTC_2001 4023502 57.655 µM 0.191053636548348 0.428750005430791 no 1420 0.424241785569242 1995 108941 YCR052W RSC6
SGTC_2715 st079500 56.4 µM 0.191051716909412 0.428750732017135 no 1421 0.424242537544406 1939 28246688
SGTC_2954 9074818 52.69 µM 0.190774402514445 0.428855698485812 no 1422 0.424351172086921 1997 16648742
SGTC_2056 5235370 200 µM 0.189730927742538 0.429250709893623 no 1423 0.424759992075968 1939 5511916
SGTC_607 4491-0986 66.8 µM 0.189231751245982 0.429439700166214 no 1424 0.424955591654236 2074 698981 YDR232W HEM1
SGTC_1040 k898-0338 155 µM 0.18907493128599 0.429499076188038 no 1425 0.425017044513708 2125 20969351
SGTC_2722 naftopidil 47.16 µM 0.188974543156348 0.429537086522268 no 1426 0.425056384452629 2049 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2695 st077686 51.995 µM 0.188154211775298 0.429847716119571 no 1427 0.425377882528684 1923 2876092
SGTC_1705 st027868 56.3335 µM 0.186315715420911 0.430544045147043 no 1428 0.426098592057107 2086 292948
SGTC_570 0987-0065 62.6 µM 0.186091607839531 0.430628940528884 no 1429 0.426186461470493 2092 3104428
SGTC_439 amiodarone 34.4 µM 0.185170212246359 0.430978012928331 no 1430 0.426547766112087 2024 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_921 1561-0023 372 µM 0.183845403163739 0.431480013708891 no 1431 0.427067368286751 2001 24050882
SGTC_2368 9071271 200 µM 0.181852218485084 0.432235485748412 no 1432 0.427849351631902 1929 27209959
SGTC_1265 0819-1001 68.8 µM 0.180101007122146 0.432899447853629 no 1433 0.428536635984133 2052 3106768
SGTC_486 niguldipine 82 µM 0.179457444320403 0.433143498842361 no 1434 0.428789264673913 2017 1236 A calcium channel blocker.
SGTC_2065 5221596 34.26 µM 0.178955868874542 0.433333723269951 no 1435 0.428986176881029 2020 788581
SGTC_1024 4507-0395 26 µM 0.177956043323881 0.433712957015789 no 1436 0.429378748495081 1985 4201836
SGTC_500 h-89 112 µM 0.177753254596948 0.433789882218391 no 1437 0.429458380016334 2113 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_746 1095-0025 46.6 µM 0.177486968989727 0.43389089792502 no 1438 0.429562949990442 2047 6749286
SGTC_1115 galangin 695.678 nM 0.176157710586933 0.434395217849752 no 1439 0.430085021619753 2085 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2466 5983409 37.09 µM 0.175941350253511 0.434477314970715 no 1440 0.430170009611621 1977 2879657
SGTC_333 3486-0131 40.1 µM 0.174581272432976 0.434993455993611 no 1441 0.430704332505569 2098 6744690
SGTC_184 1494-0393 24.714 µM 0.174110497876951 0.435172137848278 no 1442 0.430889311549721 1953 3090647
SGTC_2337 9009472 200 µM 0.173932500165015 0.435239700093324 no 1443 0.430959255234868 2099 5742383
SGTC_3326 9140064 16.379 µM 0.173810293687736 0.435286086862746 no 1444 0.431007277169871 1982 1868434
SGTC_483 fpl-64176 144 µM 0.173039299053956 0.435578759208437 no 1445 0.431310268677119 2099 3423
SGTC_1838 st055369 84.5 µM 0.172213261348942 0.43589236525628 no 1446 0.431634936294452 2111 676036
SGTC_1846 st056244 14.8 µM 0.172118844193182 0.435928213395633 no 1447 0.431672049159747 2028 5393182
SGTC_1197 1601-0112 267 µM 0.171968668857545 0.43598523278686 no 1448 0.431731080320599 1945 7350313
SGTC_675 1309-0189 238 µM 0.170976159484902 0.436362107564059 no 1449 0.432121255762318 1978 4246530
SGTC_1663 st014140 55.4 µM 0.170460430497722 0.436557962550802 no 1450 0.432324025390234 2122 4207120
SGTC_623 k072-0108 16.9 µM 0.170377946215167 0.43658928850528 no 1451 0.432356457464427 2018 5382803
SGTC_2864 9034755 47.6 µM 0.169328900712177 0.43698773056841 no 1452 0.432768972359537 2144 4930451
SGTC_2200 6600604 21.907 µM 0.169216587067339 0.437030392647311 no 1453 0.432813141669059 2060 2904777
SGTC_2519 cryptotanshinone 88.04 µM 0.168955507265459 0.437129566036508 no 1454 0.432915819120294 2081 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.16865295079537 0.437244499633514 no 1455 0.433034814178819 1973 279621
SGTC_1169 aniline yellow 25.8 µM 0.166673890246669 0.437996425174531 no 1456 0.433813325347542 2048 6051 A DNA damaging agent.
SGTC_387 norethindrone acetate 66.7 µM 0.165621802660417 0.4383962473466 no 1457 0.434227294108863 1985 541197
SGTC_762 1165-0429 115 µM 0.164717907017998 0.438739802748005 no 1458 0.434583010872752 2123 5967793
SGTC_2219 9098279 200 µM 0.164316992677495 0.438892198281652 no 1459 0.434740802643065 2112 902349
SGTC_269 exalamide 29 µM 0.163779874334071 0.439096381866897 no 1460 0.434952217840404 2014 3316 A derivative of salicylamide.
SGTC_1804 st050076 49.1 µM 0.163518108788713 0.439195896964331 no 1461 0.435055258143705 2062 3895976
SGTC_3342 9147791 14.508 µM 0.161775971522663 0.439858300829648 no 1462 0.435741137856188 2076 1838168
SGTC_2171 5739187 198.077 µM 0.161492385874929 0.439966143122854 no 1463 0.435852803920131 2011 2262761
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.159643772265556 0.440669244944451 no 1464 0.436580847938281 2067 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_373 0844-0104 25.9 µM 0.158381238260049 0.441149544866919 no 1465 0.437078198438559 2144 5375804
SGTC_1717 st033143 58.0435 µM 0.156294468651389 0.441943594360298 no 1466 0.437900458068926 2117 674616
SGTC_173 1273-0061 2.693 µM 0.155619482954916 0.44220048740546 no 1467 0.438166483433389 1974 2847414 YPL266W DIM1
SGTC_379 3970-0972 5.9 µM 0.155511653567951 0.44224152848466 no 1468 0.43820898374343 2033 2898042 YBL034C STU1
SGTC_2276 7947513 42.08 µM 0.155383538630662 0.442290291278611 no 1469 0.438259480408563 1868 2105100
SGTC_3067 9117431 49.47 µM 0.154395422690007 0.442666414874944 no 1470 0.438648981275542 1996 17150885
SGTC_1511 0906-3109 28.5 µM 0.153656835958328 0.442947589639528 no 1471 0.438940160205693 2137 2882180
SGTC_3099 9120367 49.47 µM 0.152218233645961 0.443495337769181 no 1472 0.439507406586053 2094 24824940
SGTC_2617 dihydrotanshinone i 20.83 µM 0.15026976174602 0.444237390828538 no 1473 0.440275894350956 2047 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1658 st012944 20 µM 0.149561020249217 0.444507355486494 no 1474 0.440555481763999 2108 24207260
SGTC_1989 st071868 50.2 µM 0.147774574706347 0.445187939207388 no 1475 0.441260337727026 2162 16414057
SGTC_1769 st044406 64.4 µM 0.146981341681359 0.445490189810089 no 1476 0.441573373771126 1995 670903
SGTC_90 0870-0863 4.608 µM 0.146913472282015 0.445516051991094 no 1477 0.441600158983469 2030 1738164
SGTC_313 3474-0040 5.03 µM 0.146569346902243 0.445647187303348 no 1478 0.441735974980734 2060 1043375 YIL048W NEO1
SGTC_690 glyoxal 20.3 µM 0.146410980306579 0.44570753780945 no 1479 0.441798479843186 2077 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1238 0333-0287 48.8 µM 0.146174935473982 0.445797492352934 no 1480 0.441891645801923 2058 7226
SGTC_1699 st031318 29.054 µM 0.145997357036936 0.445865167723057 no 1481 0.441961737425513 2117 5340658
SGTC_2900 5328528 85.29 µM 0.144950245739818 0.44626425518681 no 1482 0.442375077473457 2106 795359
SGTC_880 0833-0487 87.2 µM 0.144547697025223 0.446417693831542 no 1483 0.442533997555534 2084 76075
SGTC_451 chloral hydrate 100 µM 0.144189534484382 0.446554220637683 no 1484 0.442675402429329 2055 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_816 0325-0417 81.3 µM 0.143265420035019 0.446906510020965 no 1485 0.443040282441225 2032 68101
SGTC_837 0091-0265 12.5 µM 0.14326039808278 0.44690842459602 no 1486 0.443042265455577 2020 759367
SGTC_459 nigericin 15.3 µM 0.13988613974513 0.448195108362197 no 1487 0.444374976244403 2077 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_879 0831-1030 162 µM 0.139563596142365 0.448318130557414 no 1488 0.44450240255898 2040 1549252
SGTC_656 4090-1979 187 µM 0.139232028648107 0.448444599759351 no 1489 0.444633399893883 2170 22330961
SGTC_906 1165-0455 526 µM 0.138238022289265 0.448823773192556 no 1490 0.445026153055337 2144 3252859
SGTC_2464 5717415 7.67 µM 0.137791907772686 0.448993963150804 no 1491 0.445202440007268 2006 5285744
SGTC_237 nikkomycin 200 µM 0.137229353230351 0.44920858764207 no 1492 0.445424754932917 2153 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2327 6189656 200 µM 0.137132441521162 0.449245562672757 no 1493 0.445463055033278 2133 5349088
SGTC_1485 3909-9022 254 µM 0.136280618165942 0.449570580456721 no 1494 0.445799722694489 2149 714516
SGTC_253 dyclonine 31.25 µM 0.134889290300764 0.450101521757638 no 1495 0.446349703630881 2109 3180 An oral anasthetic.
SGTC_2915 7971052 15.16 µM 0.134790108962438 0.450139373533037 no 1496 0.446388913185954 2182 5741558
SGTC_248 streptozotocin 5.23457 mM 0.133881115268075 0.450486304891303 no 1497 0.446748291833756 2181 5300 DNA alkylating agent.
SGTC_842 0271-0008 11.1 µM 0.133303206219442 0.450706892417738 no 1498 0.446976796017875 2124 1221709
SGTC_1962 st076595 64.5 µM 0.132802253183956 0.450898118204057 no 1499 0.447174886181171 2119 279619
SGTC_2261 9010538 184.68 µM 0.132410335620895 0.451047730484411 no 1500 0.447329870007501 2011 6457250
SGTC_2949 9072542 2.23 µM 0.131913827602575 0.451237279554643 no 1501 0.447526225682257 2069 16457352
SGTC_1850 st056238 17 µM 0.130797434847636 0.451663519074303 no 1502 0.447967776129502 2173 5393177
SGTC_3133 9127736 49.47 µM 0.130342808367 0.451837111772433 no 1503 0.448147606377659 2206 27243420
SGTC_2406 ethylparaben 405.7 µM 0.127919102585289 0.452762724196443 no 1504 0.449106496781767 1813 8434 A possible steroid mimic.
SGTC_391 gliotoxin 8.33 µM 0.127019845286818 0.453106215826661 no 1505 0.449462345751664 2113 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2794 7785382 27.27 µM 0.125254130349082 0.453780772373826 no 1506 0.450161182399145 2231 2205081
SGTC_1196 1588-0294 184 µM 0.124860321561601 0.453931237506397 no 1507 0.450317065642358 2052 6144269
SGTC_2580 diallyl disulphide 81.36 µM 0.124744061051326 0.453975659194989 no 1508 0.450363087070819 2085 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3094 9117742 49.47 µM 0.124265683859797 0.454158447196178 no 1509 0.450552458486825 2197 17149698
SGTC_1258 0671-0043 57.1 µM 0.123210568763764 0.454561641112882 no 1510 0.450970178337816 2063 4298767
SGTC_947 3447-0010 211 µM 0.123011441730402 0.454637739316361 no 1511 0.451049018795306 2183 748350
SGTC_389 tpck 16.7 µM 0.122452866505043 0.454851212786092 no 1512 0.451270186036847 2089 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3104 9120930 49.47 µM 0.121917978144199 0.455055645951781 no 1513 0.451481988671014 2097 17014836
SGTC_1917 st066507 28.5 µM 0.121600527127998 0.455176980670374 no 1514 0.451607698000313 2059 3156428
SGTC_807 1315-0151 48 µM 0.121593606945625 0.455179625718381 no 1515 0.451610438418871 2214 4011080
SGTC_2179 6298986 200 µM 0.121108080709172 0.455365209625554 no 1516 0.451802714405411 2184 738374
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.120816738099121 0.455476574918507 no 1517 0.451918096068163 2201 688801
SGTC_1274 0865-0114 173 µM 0.120032890393606 0.455776216919626 no 1518 0.452228546771061 2104 870624
SGTC_913 3487-1245 167 µM 0.118077858178832 0.456523677679373 no 1519 0.453002983659082 2102 4016153
SGTC_2966 9084041 48.03 µM 0.117741495110706 0.456652293804218 no 1520 0.45313624354522 2000 17741380
SGTC_1946 st076057 65.1 µM 0.117653032276403 0.456686120350294 no 1521 0.453171291513868 2160 953009
SGTC_1405 3909-7894 12 µM 0.117460174637473 0.456759866619912 no 1522 0.453247700780695 2200 7104060
SGTC_2023 5144124 124 µM 0.115241379502609 0.457608411707056 no 1523 0.454126900521493 2117 2830192
SGTC_543 3844-1095 191 µM 0.114609859292861 0.457849962689194 no 1524 0.454377182312082 2152 4230703
SGTC_1010 4112-3296 15.2 µM 0.113273551150348 0.45836114013925 no 1525 0.454906842692961 2216 704384
SGTC_1594 piperine 70.1 µM 0.113231198091572 0.458377342569305 no 1526 0.454923631107892 2143 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1370 2001-0092 44.6 µM 0.112818271442938 0.458535313885889 no 1527 0.455087316154751 2177 790957
SGTC_1889 st059080 5.18 µM 0.112800086177161 0.458542271084295 no 1528 0.45509452501028 2240 176925 Isolated from Daphnopsis sellowiana.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.112195502659147 0.45877357585453 no 1529 0.455334197507348 2183 66535 A nucleotide analog.
SGTC_1990 st072050 59.8 µM 0.111114675875797 0.459187119032714 no 1530 0.45576270557119 2144 17233948
SGTC_368 fentichlor 4.58 µM 0.109449129433085 0.459824472466658 no 1531 0.456423134057455 2091 7329 A pesticide.
SGTC_1977 st070720 65.3 µM 0.108806560211168 0.460070391650663 no 1532 0.456677960209481 2087 682188
SGTC_2895 9054447 58.44 µM 0.108518009105251 0.460180828701237 no 1533 0.456792397836358 2114 2697450
SGTC_496 calpeptin 138 µM 0.104069203170132 0.461883902073697 no 1534 0.458557215215429 2100 73364 A calpain inhibitor.
SGTC_2402 5553605 200 µM 0.10292749613985 0.462321079587177 no 1535 0.459010257414247 2174 6758546
SGTC_2286 7945697 125 µM 0.102908675791367 0.462328286576379 no 1536 0.459017725988002 2118 1245733
SGTC_2569 tetrandrine 100 µM 0.10245206766985 0.46250314205408 no 1537 0.459198928516865 2045 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_524 r073-0010 27.8 µM 0.10244019507617 0.462507688692965 no 1538 0.459203640206389 2083 2772106
SGTC_1327 1436-0082 2.18 µM 0.102036255173587 0.462662381384565 no 1539 0.459363948892324 2093 15992205
SGTC_2013 4024628 200 µM 0.102021926999379 0.462667868601268 no 1540 0.45936963533192 2160 5230760
SGTC_1626 st003712 1.76 µM 0.10069981280536 0.463174225033783 no 1541 0.459894379989709 2159 24207035
SGTC_2741 miltefosine 3.04 µM 0.100484020040468 0.46325687717751 no 1542 0.459980034392115 2176 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_693 4161-2696 114 µM 0.100469994669951 0.463262249177792 no 1543 0.459985601532474 2183 805759
SGTC_2117 5521686 200 µM 0.100189113377826 0.463369833796924 no 1544 0.460097094396152 2156 803312
SGTC_1106 tegaserod maleate 11.7 µM 0.0996468671128666 0.463577535363993 no 1545 0.460312342194288 2129 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2473 5854593 8.94 µM 0.0992522127657318 0.463728709688918 no 1546 0.460469009841706 2097 2872951
SGTC_3240 9133527 49.47 µM 0.0990477041236928 0.463807049810416 no 1547 0.460550196939622 2173 17617455
SGTC_2190 6049624 200 µM 0.0989766056576468 0.46383428547966 no 1548 0.460578422431168 2206 2265554
SGTC_438 sphingosine 6.67 µM 0.0976524008949769 0.464341579061852 no 1549 0.461104156705276 2133 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2354 9060492 162 µM 0.0974173314820031 0.464431638592329 no 1550 0.461197490829131 2208 6471895
SGTC_1182 1222-0449 220 µM 0.0968441907978167 0.464651227238788 no 1551 0.461425064831259 2175 658318
SGTC_2597 laccaic acid a 100 µM 0.0966097412358859 0.464741055519919 no 1552 0.461518160148847 2163 5491415 A textile dye.
SGTC_2796 7949634 45.45 µM 0.0935985541817334 0.465894936274307 no 1553 0.462714029084707 2198 2971588
SGTC_2999 9069765 71.4286 µM 0.0926831826468454 0.466245762068618 no 1554 0.463077628899677 2205 2097066
SGTC_41 0478-0632 82.643 µM 0.0921213575990548 0.466461100450721 no 1555 0.463300809846364 2259 3750424
SGTC_2288 7946289 167.31 µM 0.0917083785907534 0.466619394837037 no 1556 0.463464870147906 2233 1246052
SGTC_2671 danthron 100 µM 0.0894869506277739 0.467470955625986 no 1557 0.464347461932941 2174 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3162 9099653 49.47 µM 0.0894346805366876 0.467490994617818 no 1558 0.464368231404255 2247 25237511
SGTC_2893 9048488 25.97 µM 0.0892307203329967 0.467569188436366 no 1559 0.464449275726584 2144 6467338
SGTC_682 0kpi-0099 17 µM 0.0878449009599134 0.468100513833091 no 1560 0.464999974937973 2135 1714895 YML126C ERG13
SGTC_2044 5102272 200 µM 0.0863040211217219 0.468691356347689 no 1561 0.465612371006203 2170 592666
SGTC_1776 st049249 45.9 µM 0.0862802526310028 0.468700470797656 no 1562 0.465621818023714 2140 1822314
SGTC_855 0428-0020 25 µM 0.085643430188856 0.468944677767549 no 1563 0.465874936485339 2139 6812414
SGTC_503 tyrphostin 8 294 µM 0.0855622072749062 0.468975825755835 no 1564 0.465907221234098 2248 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1596 piperlongumine 63 µM 0.0844147670323965 0.469415875173682 no 1565 0.46636333339912 2253 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1394 3474-0001 65.7 µM 0.0843695468204828 0.469433218133473 no 1566 0.466381309526155 2192 5017666 YIL048W NEO1
SGTC_2555 cholic acid 100 µM 0.0834310910954252 0.469793149875528 no 1567 0.466754383782024 2170 6708657 Influences liver metabolism.
SGTC_881 0833-0569 170 µM 0.0817558044153193 0.470435744134863 no 1568 0.467420450667248 2057 5418700
SGTC_79 0052-0007 94.094 µM 0.0814988189827302 0.470534323587801 no 1569 0.467522632035642 2256 2801472
SGTC_1058 3448-5425 97.3 µM 0.0800487584501879 0.471090599577342 no 1570 0.468099238362826 2250 7279705
SGTC_2216 7189485 200 µM 0.079707275426435 0.47122160842893 no 1571 0.468235036456886 2247 731273
SGTC_2505 galangin 7.89 µM 0.0784142414808968 0.471717704801042 no 1572 0.468749272674664 2177 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0779036630533509 0.4719136097802 no 1573 0.468952342786878 2238 23847180
SGTC_3295 9122362 53.5725 µM 0.0766952566913521 0.472377292908793 no 1574 0.469432989019975 2160 4730473
SGTC_407 eburnamonine 100 µM 0.0757606774327315 0.47273593029437 no 1575 0.469804750518761 2232 3195
SGTC_1622 st003707 19.4 µM 0.0756313917502445 0.472785544397568 no 1576 0.469856180488426 2200 10140899
SGTC_331 k048-0133 24.5 µM 0.0754983375028279 0.472836605149476 no 1577 0.46990911012195 2272 6813582
SGTC_662 k832-1615 104 µM 0.0744621226032315 0.47323427705128 no 1578 0.470321339624058 2214 5878478
SGTC_1694 st024011 44.9 µM 0.0742866965500278 0.473301603587068 no 1579 0.470391131198603 2270 2787533
SGTC_1906 st060206 94.7 µM 0.0729091248638036 0.473830326382538 no 1580 0.470939216340011 2267 5133468
SGTC_1120 ficusin 1.78878 µM 0.0715945965868902 0.474334895622827 no 1581 0.471462270170407 2194 6199 A DNA cross-linker.
SGTC_185 k048-0037 25.491 µM 0.0712572256841253 0.474464398922998 no 1582 0.471596518804435 2289 6827589
SGTC_1398 3558-0053 112 µM 0.0711328364883523 0.474512147680115 no 1583 0.471646017307389 2213 4532369
SGTC_1202 1988-0068 29.6 µM 0.0709398223175067 0.47458623994219 no 1584 0.471722824784642 2186 2850480
SGTC_2301 7769476 200 µM 0.0692913877120064 0.475219059333159 no 1585 0.472378840436192 2221 977820
SGTC_78 0336-0123 156.75 µM 0.0683714709547091 0.475572234480424 no 1586 0.472744965776129 2084 6765896
SGTC_3306 9127676 59.7925 µM 0.0673540597896422 0.475962862096674 no 1587 0.473149920534381 2191 41905287
SGTC_2241 6772625 37.8075 µM 0.0665822912672583 0.476259192436517 no 1588 0.473457121989327 2309 2285411
SGTC_2467 5474540 200 µM 0.0664048470497559 0.47632732626307 no 1589 0.473527755667595 2276 5413519
SGTC_1750 st081859 2.357 µM 0.0662833693156701 0.47637397085831 no 1590 0.473576111734033 2235 5291695
SGTC_3058 9093861 49.47 µM 0.0648919436367708 0.476908268553786 no 1591 0.47413001756101 2257 17217477
SGTC_736 0958-0254 92.6 µM 0.063970959601794 0.477261942852651 no 1592 0.474496675155415 2238 6812352
SGTC_45 0kpi-0036 14.9 µM 0.0632435086886126 0.477541309654406 no 1593 0.474786299589327 2250 2795021
SGTC_3191 9110352 49.47 µM 0.063056559642142 0.477613106468529 no 1594 0.474860732902766 2302 17122424
SGTC_2135 5326629 150.42 µM 0.0620047868612971 0.478017047840035 no 1595 0.475279509987292 2234 5020077
SGTC_1203 3992-3522 103 µM 0.0611356167192583 0.478350876334446 no 1596 0.475625602074371 2306 5322312
SGTC_740 k014-0057 261 µM 0.0611346840671037 0.478351234553138 no 1597 0.475625973454082 2286 4012779
SGTC_3177 9107506 49.47 µM 0.0594721889815953 0.478989803270173 no 1598 0.476288008117526 2293 8897194
SGTC_2136 5328288 199.296 µM 0.0592078722773097 0.479091333020008 no 1599 0.476393269737064 2246 262395
SGTC_1364 1653-0028 37.6 µM 0.059012236946632 0.479166481646251 no 1600 0.476471180712508 2248 5718652
SGTC_397 arbidol 50 µM 0.0572834041759003 0.479830603231544 no 1601 0.477159720096368 2295 131410 A RNA synthesis inhibitor.
SGTC_635 k038-0028 24.7 µM 0.0571002675128209 0.479900957483896 no 1602 0.477232661664149 2247 4035102
SGTC_3096 9117468 49.47 µM 0.0552796583993102 0.480600401070067 no 1603 0.477957833814179 2306 41316311
SGTC_1325 1431-0015 227 µM 0.0552523745906431 0.480610883452951 no 1604 0.47796870186902 2278 1103340
SGTC_301 4119-0100 24.5 µM 0.0533220743691046 0.481352534409301 no 1605 0.478737646207836 2284 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1235 benzylparaben 21.5 µM 0.053007280237139 0.481473489333045 no 1606 0.478863053540047 2275 7180
SGTC_3059 1327-0034 3 µM 0.0525726581639222 0.481640489146519 no 1607 0.479036201229192 2262 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1608 st001473 40.5 µM 0.0518052377455002 0.481935371725569 no 1608 0.479341941020169 2220 7292267
SGTC_1678 st019265 80.2 µM 0.0513017205687247 0.482128854422549 no 1609 0.479542548548116 2321 5367020
SGTC_1481 3346-2004 36 µM 0.0506137390572512 0.482393226615377 no 1610 0.47981665733684 2326 2770522
SGTC_507 nimesulide 162 µM 0.0489698221987745 0.483024969355072 no 1611 0.480471672735915 2312 4495 A COX2 inhibitor.
SGTC_771 0250-0039 27.3 µM 0.0488079761620783 0.483087167688898 no 1612 0.480536162847032 2222 3005115
SGTC_2322 7413319 38.22 µM 0.0487336428251033 0.483115734542561 no 1613 0.480565782310725 2272 1840400
SGTC_422 cantharidin 155 µM 0.0486421524840429 0.483150895079343 no 1614 0.480602238440557 2334 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_117 lucigenin 22.078 µM 0.0474429226608607 0.483611781583242 no 1615 0.481080110089707 2200 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2931 9014674 55.67 µM 0.047003615967324 0.483780620894317 no 1616 0.481255172795381 2311 2996810
SGTC_3188 9110789 49.47 µM 0.0468741622253061 0.483830374574963 no 1617 0.481306760504527 2307 849217
SGTC_1590 st077108 57.8 µM 0.0466401361373669 0.483920319768603 no 1618 0.481400021404836 2308 5489485
SGTC_2693 st077581 40.7 µM 0.0466063392594298 0.483933309271638 no 1619 0.481413489762171 2332 25238761
SGTC_1834 st055981 52.8 µM 0.0455162510013243 0.484352283214176 no 1620 0.481847910948375 2314 471719 YDL150W RPC53
SGTC_594 1487-1584 10.8 µM 0.0450203435330773 0.484542890321993 no 1621 0.482045546799281 2307 5013332
SGTC_219 mitoxanthrone 164.414 µM 0.0443980593533485 0.484782076603212 no 1622 0.482293554268453 2299 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1075 aripiprazole 15.2 µM 0.041392064292671 0.485937561230032 no 1623 0.483491669577075 2323 60795 An atypical antipschotic. YIL048W NEO1
SGTC_617 3770-0098 35 µM 0.0393853932924082 0.48670897861534 no 1624 0.484291562669136 2298 5962639
SGTC_1899 st063254 59.6 µM 0.0393514481114362 0.48672202847627 no 1625 0.484305094346789 2323 3093813
SGTC_2920 7982904 15.77 µM 0.038799964006874 0.486934042610264 no 1626 0.484524936766316 2300 6456808
SGTC_604 1000-0114 314 µM 0.0374824787183483 0.487440555277797 no 1627 0.48505015514334 2340 1572745
SGTC_1279 0874-0590 65.2 µM 0.0372311720329894 0.487537173498081 no 1628 0.485150342073765 2301 3523074
SGTC_2009 4012297 12.05 µM 0.0367472051342063 0.48772324310866 no 1629 0.485343284892775 2281 45595307
SGTC_1613 st002381 52.1 µM 0.0353052341056963 0.488277649988929 no 1630 0.485918174860771 2354 551167
SGTC_1469 k284-2957 126 µM 0.0324017866604357 0.489394030780772 no 1631 0.487075818844291 2309 23884841
SGTC_2290 7904846 200 µM 0.0320233781974996 0.489539535826479 no 1632 0.48722670367535 2324 2962154
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0314384489076094 0.489764454678205 no 1633 0.487459939250527 2367 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1546 5-methoxyflavanone 78.7 µM 0.031244147994555 0.489839168600597 no 1634 0.487537416038564 2356 147795
SGTC_2144 5628481 200 µM 0.030379355299667 0.490171708919061 no 1635 0.487882254670043 2351 2818399
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0302507411537926 0.490221165741247 no 1636 0.487933540719244 2336 107982 A Capsaicinoid.
SGTC_600 1495-0418 41.6 µM 0.030131602180078 0.490266979148885 no 1637 0.487981048636244 2336 5377768
SGTC_216 k038-0035 28.382 µM 0.0296392406226988 0.490456312005148 no 1638 0.488177384779489 2342 4444231 YPR107C YTH1
SGTC_3018 9082602 49.47 µM 0.0290292655658612 0.49069087496821 no 1639 0.488420624939481 2330 17332089
SGTC_3341 9147222 25.867 µM 0.0286844432832855 0.490823476141695 no 1640 0.488558131862375 2311 1939759
SGTC_2589 lobaric acid 100 µM 0.027996933343611 0.491087860632234 no 1641 0.48883229851341 2344 73157 A novel microtubule depolymerizer.
SGTC_403 arphamenine a 50 µM 0.0278058285671961 0.491161351381355 no 1642 0.488908508618528 2361 5487158 An arginine aminopeptidase inhibitor.
SGTC_3123 9126162 49.47 µM 0.0268532837943749 0.491527663914024 no 1643 0.489288377098768 2361 25239884
SGTC_1749 st037932 54.2 µM 0.02635630421263 0.491718786237108 no 1644 0.489486573108909 2321 594497
SGTC_728 3030-5151 22.5 µM 0.0261193031894915 0.491809929861209 no 1645 0.489581090297844 2354 3125388
SGTC_1835 st008666 49.2 µM 0.0255293873756753 0.492036795982323 no 1646 0.489816354192991 2328 690455
SGTC_819 1013-0258 27.7 µM 0.0251967313784666 0.49216472787837 no 1647 0.489949022056023 2341 5753198
SGTC_72 0744-0168 198.391 µM 0.0240318299167038 0.492612728631266 no 1648 0.490413609715849 2287 677577
SGTC_1999 st074831 12.5 µM 0.0230476237328944 0.492991244421696 no 1649 0.490806142389443 2331 17112523
SGTC_44 0929-0055 61.211 µM 0.0228603796577927 0.493063257332955 no 1650 0.49088082229115 2334 1379590
SGTC_1323 1348-1351 11.2 µM 0.0225057503504738 0.493199646185158 no 1651 0.491022262523271 2278 6989654
SGTC_3241 9133421 49.47 µM 0.0217228031486308 0.493500766984368 no 1652 0.491334536890577 2367 17018221
SGTC_2104 5389443 200 µM 0.0216936076030361 0.493511995637991 no 1653 0.491346181484055 2353 2244536
SGTC_1754 st042065 16.137 µM 0.0210569070299343 0.493756872961903 no 1654 0.491600130236906 2345 1126236 YIL048W NEO1
SGTC_1865 st057639 52.2 µM 0.0209038237997708 0.493815749675557 no 1655 0.49166118817019 2364 688818
SGTC_2853 9015042 58.44 µM 0.0208025861306344 0.493854686354588 no 1656 0.491701567376233 2359 6457456
SGTC_640 3381-0960 37.1 µM 0.0205632535317708 0.49394673549168 no 1657 0.491797026848609 2357 1745025
SGTC_513 4245-1575 41.7 µM 0.0205546920766141 0.493950028298423 no 1658 0.491800441653306 2338 719745
SGTC_3107 9121808 49.47 µM 0.0182755547557866 0.49482661739299 no 1659 0.492709514344439 2377 662681
SGTC_425 3825-7017 13.1 µM 0.0160269388457714 0.495691492012466 no 1660 0.493606450181003 2341 3397440
SGTC_206 4546-0025 72.014 µM 0.0158025483038671 0.495777799475224 no 1661 0.493695957719393 2359 6620745 YIL048W NEO1
SGTC_1286 0929-0070 131 µM 0.0151767430948938 0.496018504322913 no 1662 0.4939455879239 2353 1420408
SGTC_2523 spermine 47.74 µM 0.0151112602144831 0.496043691233953 no 1663 0.493971708818069 2377 1103 A DNA binding polyamine.
SGTC_1644 st010134 20.9 µM 0.0146060013019281 0.496238031272654 no 1664 0.494173255708814 2377 3818134
SGTC_1125 tnp00248 1.32998 µM 0.0135996108460097 0.496625126435954 no 1665 0.49457470747115 2385 24207736
SGTC_317 4495-0002 170 µM 0.01318872836235 0.496783168040286 no 1666 0.494738611161875 2355 15991618
SGTC_1727 st034309 9.9045 µM 0.013086170470947 0.496822615928885 no 1667 0.494779522310294 2383 870305
SGTC_424 splitomicin 100 mM 0.0129876858089808 0.496860497118915 no 1668 0.494818808667181 2318 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2485 5633444 17.78 µM 0.0123053881178637 0.497122937205675 no 1669 0.495090984292649 2374 5724239
SGTC_777 1315-0167 517 µM 0.011610589868212 0.497390186806296 no 1670 0.495368148868134 2335 4221767
SGTC_853 0419-0306 21 µM 0.0115886447968827 0.497398627854106 no 1671 0.495376903095968 2374 762713
SGTC_3207 9114163 49.47 µM 0.0108631757620324 0.4976776760561 no 1672 0.495666305124796 2382 849233
SGTC_1863 st057641 20.1 µM 0.00856806705098731 0.49856048550341 no 1673 0.496581877613835 2392 3921635
SGTC_2273 7815444 169.05 µM 0.00812482738609805 0.498730977791242 no 1674 0.496758698496003 2387 2824616
SGTC_1714 st033236 13.627 µM 0.00797147606445869 0.498789964484807 no 1675 0.496819874840589 2392 2916566
SGTC_3062 9077494 49.47 µM 0.00605840399250623 0.499525830809699 no 1676 0.49758306128097 2372 16459633
SGTC_1348 1493-0373 93.8 µM 0.00576463589945249 0.499638829396226 no 1677 0.497700255745739 2383 3010129
SGTC_703 3875-0075 71.8 µM 0.00493489125744362 0.499957992747078 no 1678 0.498031271219017 2391 2850814
SGTC_914 3820-6779 408 µM 0.00471647465271913 0.499957992747078 no 1679 0.498118405822643 2397 2893481
SGTC_3050 9093513 49.47 µM 0.00446107049374928 0.499859750886486 no 1680 0.498220296267219 2399 25236664
SGTC_519 k048-0011 62.8 µM 0.00383154956964848 0.499617604107568 no 1681 0.498471436617296 2389 6836379
SGTC_1119 parthenolide 318.541 nM 0.00342687890228561 0.499461946604258 no 1682 0.498632875791867 2395 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1448 4255-0083 152 µM 0.00307459970224225 0.499326441665259 no 1683 0.498773414115986 2399 5399660
SGTC_2069 5228469 200 µM 0.00267800430350599 0.499173890500521 no 1684 0.498931632133238 2392 2835210
SGTC_2859 9028643 45.46 µM 0.00223902872314861 0.499005037861127 no 1685 0.499106757521644 2400 17151580
SGTC_1728 st035614 33.7865 µM 0.00219780421361649 0.498989180798135 no 1686 0.499123203681015 2388 15945546
SGTC_3302 9125395 16.351 µM 0.001719630801689 0.498805250875804 no 1687 0.499313966904641 2399 17599668
SGTC_3153 9100258 49.47 µM 0.00160460617820618 0.498761006565847 no 1688 0.499359855026824 2401 25236848
SGTC_1079 idarubicin 2.36 µM 0.00135762758724898 0.498666006112931 no 1689 0.499458385120787 2400 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2619 obliquin 87.91 µM 0.0013037463233193 0.49864528066454 no 1690 0.499479880616056 2398 6708593 A bioactive alkalod. YER133W GLC7
SGTC_210 3551-0445 56.827 µM 0.000898657075314888 0.498489463054243 no 1691 0.49964148774533 2380 2865180 YOR207C RET1
SGTC_2800 7887935 81.82 µM 0.000405586108801184 0.498299803582441 no 1692 0.499838194557292 2404 2961002
SGTC_3288 9119690 36.221 µM 0.000175220668653189 0.498211193773684 no 1693 0.499930097067232 2404 17595618 YKL019W RAM2
SGTC_2867 9039098 71.43 µM -0.000537690723598127 0.497936973782935 no 1694 0.499785492446913 2409 6463460
SGTC_2194 5927483 104.545 µM -0.000635875878253511 0.497899207126193 no 1695 0.499746322244173 2396 760979
SGTC_1151 3909-8316 15.3 µM -0.00104112008669268 0.497743331229844 no 1696 0.499584653253478 2409 800431
SGTC_2411 st077133 39.94 µM -0.00112856384883477 0.497709696309128 no 1697 0.499549768260141 2410 1403142 YNL221C POP1
SGTC_1132 3456-3614 2.5 µM -0.00199848915710021 0.497375083672046 no 1698 0.499202718709027 2415 3125502
SGTC_489 paxilline 115 µM -0.00222317888121621 0.49728865812772 no 1699 0.499113080677991 2411 105008 A toxic potassium channel blocker.
SGTC_149 3970-0822 46.1 µM -0.00260114190539576 0.497143277224076 no 1700 0.498962295686788 2414 3114250 YBL034C STU1
SGTC_2020 4017018 200 µM -0.00311698425605805 0.49694486259235 no 1701 0.498756505206461 2409 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2939 9044578 71.43 µM -0.00417453754283072 0.496538085601178 no 1702 0.498334605310116 2413 2653634
SGTC_2857 9024691 58.44 µM -0.0043195695958731 0.496482300785301 no 1703 0.498276746414011 2421 16478292
SGTC_2399 5884133 200 µM -0.00525652637886147 0.496121913455844 no 1704 0.497902959036679 2417 722445
SGTC_664 1222-0054 14.9 µM -0.00530460255376369 0.496103421710049 no 1705 0.497883779685236 2424 6813991
SGTC_2122 5258151 111.688 µM -0.00564474134948968 0.49597259290451 no 1706 0.497748085972594 2424 2173356
SGTC_2885 9057732 51.95 µM -0.00645480916191139 0.495661015385295 no 1707 0.497424921594989 2417 6471414
SGTC_1234 0326-0494 15.5 µM -0.00710207779053264 0.495412057437803 no 1708 0.497166704709014 2423 1547813
SGTC_2170 morpholine 200 µM -0.00722938270096096 0.495363092551084 no 1709 0.497115918701664 2420 121171 Reacts with secondary amines.
SGTC_615 k087-0205 167 µM -0.00750604449388638 0.495256681238958 no 1710 0.497005549611081 2419 9642773
SGTC_3010 9080089 71.4286 µM -0.00871724212058835 0.49479082724307 no 1711 0.496522367594051 2415 17027233
SGTC_2634 4'-methoxyflavone 100 µM -0.00885920460033694 0.494736225716049 no 1712 0.496465734945689 2429 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_138 0850-0259 40.9225 µM -0.00896329073366683 0.494696192230125 no 1713 0.496424212235018 2422 6813004
SGTC_1098 clofazimine 15.1 µM -0.00933908516797569 0.4945516550652 no 1714 0.496274298224664 2450 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2899 9053889 58.44 µM -0.00991137789591625 0.494331542572524 no 1715 0.496045997037574 2431 6470052
SGTC_1440 4100-1550 40 µM -0.011414659062542 0.493753366151587 no 1716 0.495446308770575 2424 742806
SGTC_1204 4049-0315 18.3 µM -0.0114937592150576 0.493722943823573 no 1717 0.495414754445373 2468 588402
SGTC_2677 mitomycin C 100 µM -0.0115163575309262 0.493714252401038 no 1718 0.495405739618357 2422 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2477 5967686 25.23 µM -0.0116661505799055 0.493656641339227 no 1719 0.495345984852241 2426 776118
SGTC_2351 9026858 72.31 µM -0.0142859006196135 0.492649096474487 no 1720 0.494300944080379 2436 1409300
SGTC_2409 alverine citrate 63.97 µM -0.0143148204085885 0.49263797429496 no 1721 0.49428940793345 2557 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1885 st057546 99.9 µM -0.0162963119254923 0.491875932192592 no 1722 0.493498999904448 2458 702008
SGTC_2357 9067248 200 µM -0.0164742184462987 0.491807514303563 no 1723 0.493428034998292 2443 9150235
SGTC_670 4204-0025 119 µM -0.0167318429581751 0.491708439524936 no 1724 0.493325271853173 2456 719039
SGTC_1997 st073024 93.8 µM -0.0171021450412993 0.491566033177806 no 1725 0.493177563833937 2432 686268
SGTC_2063 5246145 200 µM -0.01767514125698 0.491345679270107 no 1726 0.492949005976668 2461 711240
SGTC_2643 anethole 100 µM -0.0184914930255656 0.491031744074718 no 1727 0.492623381994449 2441 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1961 st076550 68.7 µM -0.0187950039336532 0.490915027713104 no 1728 0.492502319701796 2458 1579337
SGTC_2808 7946468 45.46 µM -0.0201645191559501 0.490388384850002 no 1729 0.491956065869525 2458 2970879
SGTC_259 usnic acid 108.925 µM -0.0208285411847185 0.490133043197721 no 1730 0.49169121505078 2469 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1812 st052057 4.327 µM -0.0209655193941844 0.490080370381121 no 1731 0.491636580581926 2433 3645418
SGTC_610 4215-0184 155 µM -0.021334875330408 0.489938341228335 no 1732 0.491489261837081 2459 5605015
SGTC_1937 st074714 47.2 µM -0.0214967574518933 0.489876092784005 no 1733 0.491424695022519 2452 17250970
SGTC_1735 st034310 56.75 µM -0.0228026086692213 0.489373963672002 no 1734 0.490903863574839 2586 871153
SGTC_3282 9108498 15.4605 µM -0.0231125750558071 0.489254777080526 no 1735 0.490780237461149 2476 16459645
SGTC_2434 5670830 169.91 µM -0.0233717742577074 0.489155111947395 no 1736 0.490676859866746 2477 1549830
SGTC_1400 3771-8998 51.5 µM -0.0235749362737519 0.489076994242542 no 1737 0.490595832275025 2456 670767
SGTC_178 4092-0806 87.505 µM -0.0236119980586279 0.489062743682988 no 1738 0.49058105087667 2451 2169044
SGTC_702 1488-0190 94 µM -0.0240701104990311 0.488886596859659 no 1739 0.490398342389366 2456 949357
SGTC_2811 7967822 32.47 µM -0.0245392986537134 0.488706193608788 no 1740 0.490211218675614 2478 2232244
SGTC_506 n9-isopropylolomoucine 153 µM -0.0247257805942139 0.488634491781183 no 1741 0.490136845711892 2448 6610355
SGTC_145 3737-0113 38.366 µM -0.025975544237006 0.488153970461206 no 1742 0.489638422369832 2474 6849351
SGTC_1523 st012844 44.7 µM -0.0273248935669774 0.487635178790826 no 1743 0.489100301041896 2532 4274103
SGTC_866 0495-0101 262 µM -0.0283146819363374 0.4872546427301 no 1744 0.4887055854016 2471 635694
SGTC_920 mycophenolic acid 780.421 nM -0.028406154871063 0.487219475439008 no 1745 0.488669107653158 2468 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_336 4111-0029 111 µM -0.0291104637675939 0.486948703218534 no 1746 0.488388245227968 2495 3131175
SGTC_172 1112-0046 2.638 µM -0.0296145232029207 0.486754920779038 no 1747 0.488187241276571 2474 2802135 YIL048W NEO1
SGTC_2191 5911152 200 µM -0.0297453670781885 0.486704619193968 no 1748 0.488135065108665 2460 2875902
SGTC_558 k064-0027 21.3 µM -0.0304878327883888 0.486419189900422 no 1749 0.487838998450014 2492 5088526
SGTC_1649 st011737 51.3 µM -0.0305958667820668 0.48637765850286 no 1750 0.487795919219175 2483 1761035
SGTC_2866 9034245 58.44 µM -0.0314627832093331 0.486044396096319 no 1751 0.487450236068801 2523 6462273
SGTC_3044 9093193 49.47 µM -0.0321553619282727 0.485778160065204 no 1752 0.487174076887464 2500 25236277
SGTC_415 dibenzyl ketone 100 µM -0.0329918836495995 0.48545659898412 no 1753 0.486840530014457 2543 7593
SGTC_1064 honokiol 6.76 µM -0.0340335967977289 0.485056175040464 no 1754 0.486425179920513 2498 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_745 0469-0705 296 µM -0.0342835921709009 0.484960081587401 no 1755 0.486325504364673 2479 3486736
SGTC_2363 9053361 176 µM -0.0378833174903418 0.483576515429208 no 1756 0.484890357107593 2497 6469797 YMR079W SEC14
SGTC_2638 epoxomicin 18 µM -0.0381588667929705 0.483470615092884 no 1757 0.484780508268419 2511 9915668 A protesome inhibitor.
SGTC_2432 5630864 12.22 µM -0.0382651234514127 0.48342977837136 no 1758 0.484738148931736 2529 5714970
SGTC_2971 9092186 9.93 µM -0.03963096082703 0.482904873289722 no 1759 0.484193671825663 2492 25236400
SGTC_1246 0422-0085 105 µM -0.0396905897226196 0.482881957972033 no 1760 0.4841699020401 2476 264295
SGTC_2745 rifampicin 24.3 µM -0.0411189444537615 0.482333059924803 no 1761 0.483600535942479 2492 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_224 benfluorex 43.875 µM -0.0412428318594289 0.482285453177903 no 1762 0.483551153908783 2477 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2233 sulbentine 40.3845 µM -0.0422156174765872 0.481911645491902 no 1763 0.48316340635649 2465 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_80 0159-0065 512.242 µM -0.0433001338225808 0.481494922333428 no 1764 0.482731142274472 2477 1548079
SGTC_639 0833-0042 114 µM -0.0434301308360117 0.48144497259853 no 1765 0.482679329710098 2502 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_579 4491-1009 110 µM -0.04481095220742 0.480914427302516 no 1766 0.482128997632114 2475 1271041
SGTC_2837 9008476 45.46 µM -0.0456012317455474 0.480610797751759 no 1767 0.481814043702148 2551 2992805
SGTC_982 1491-0518 27.5 µM -0.0475659685975828 0.479855984653158 no 1768 0.481031077219934 2521 3091256
SGTC_1168 k815-0004 80.5 µM -0.048795350193173 0.479383717087513 no 1769 0.480541193885325 2485 642433
SGTC_966 1300-0360 30.2 µM -0.0501161815829598 0.478876351305501 no 1770 0.480014902451528 2519 70588
SGTC_996 3970-0799 1.8 µM -0.0512020935739043 0.478459249791877 no 1771 0.479582241802068 2474 6615648 YGL040C HEM2
SGTC_3227 9130768 49.47 µM -0.052071871068637 0.478125183072447 no 1772 0.479235713092136 2508 17720899
SGTC_588 3970-1144 52.9 µM -0.0523817092036693 0.478006183223143 no 1773 0.479112274023857 2543 1888707
SGTC_2426 5582046 32.21 µM -0.0537756161654625 0.477470848358035 no 1774 0.478556968441511 2545 2251934
SGTC_3102 9121669 49.47 µM -0.0540219122380778 0.477376261684628 no 1775 0.478458853144686 2535 41905072
SGTC_134 0269-0018 6.916 µM -0.0545384281429263 0.47717790488694 no 1776 0.478253096451671 2556 4378915
SGTC_1547 harmine 94.2 µM -0.0549054403281093 0.477036965202889 no 1777 0.47810689883201 2494 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_262 fenpropimorph 62.5 µM -0.0553945797285039 0.476849130805241 no 1778 0.47791205697959 2503 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2755 lomerizine 42.69 µM -0.0554329026194095 0.476834414650483 no 1779 0.477896791813344 2528 3949 A calcium channel blocker.
SGTC_1193 1488-0126 41.5 µM -0.0556285240511474 0.476759295672888 no 1780 0.477818870387658 2538 1384710
SGTC_2651 TUB2.036 5 µM -0.0558270385647024 0.476683066591019 no 1781 0.477739797434349 2550 15992207 YFL037W TUB2
SGTC_2649 anisomycin 9.56 µM -0.056979800251916 0.476240425907891 no 1782 0.477280643029119 2539 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1720 st037298 9.481 µM -0.0578437625209717 0.475908698429824 no 1783 0.476936539531515 2551 597396
SGTC_2675 theaflavin digallate 100 µM -0.0579668398599947 0.475861442933298 no 1784 0.476887521026287 2533 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.05871201664086 0.4755753398721 no 1785 0.476590743977542 2527 689007
SGTC_1845 st056753 3.01 µM -0.0598754617590972 0.475128672162358 no 1786 0.476127411750893 2488 5375839
SGTC_2907 7721985 69.9 µM -0.0600024528914628 0.475079919842395 no 1787 0.476076840543679 2555 3267881
SGTC_2784 7567673 72.73 µM -0.0602351278007427 0.474990596136032 no 1788 0.475984184278705 2501 3471247
SGTC_2468 5987765 72.9 µM -0.0610832594517439 0.4746650097682 no 1789 0.475646450637644 2577 26772094
SGTC_669 0108-0021 26.2 µM -0.061884832831469 0.474357312044257 no 1790 0.475327272996362 2490 17201
SGTC_320 4092-0846 5.34 µM -0.0621390452210585 0.474259731433577 no 1791 0.475226051735646 2605 1359356
SGTC_2232 chlorophetanol 41.5365 µM -0.0632618074395224 0.473828772473969 no 1792 0.474779014032885 2531 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2387 9077560 195.08 µM -0.0634931369135216 0.473739983187918 no 1793 0.474686912084211 2505 5303272
SGTC_754 3474-0146 171 µM -0.0635256205211344 0.473727515376796 no 1794 0.474673979108231 2510 24762078
SGTC_1572 epiandrosterone 68.9 µM -0.064005542686368 0.473543315353254 no 1795 0.474482906717075 2542 441302 A steroid.
SGTC_614 0462-0418 107 µM -0.0646690405117325 0.473288666060126 no 1796 0.474218756649025 2526 5188303
SGTC_2831 7999036 19.48 µM -0.0661605856677967 0.472716253671683 no 1797 0.47362498803505 2669 2988270
SGTC_3251 9135047 49.47 µM -0.066985465798782 0.472399712379682 no 1798 0.473296636911415 2619 17682963
SGTC_454 lyso-paf C-16 6.67 µM -0.0671033838357644 0.472354463675544 no 1799 0.473249700029084 2559 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_831 k061-1017 217 µM -0.0671489883140976 0.472336963958604 no 1800 0.473231547417759 2590 1240153
SGTC_626 0214-0009 33 µM -0.0675966976194601 0.472165168186421 no 1801 0.473053342153064 2592 3437874
SGTC_1255 0566-0045 221 µM -0.0697587341172866 0.471335621339288 no 1802 0.472192846264063 2613 2788469
SGTC_1880 MG-132 525 µM -0.07071403310263 0.470969124250247 no 1803 0.471812675998626 2567 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_488 nitrendipine 139 µM -0.0709230130607736 0.470888953092546 no 1804 0.471729513859415 2524 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2628 lathosterol 100 µM -0.0720742642888374 0.470447318851813 no 1805 0.47127140353483 2613 6710616
SGTC_2841 9004761 38.96 µM -0.0721096388454767 0.470433749306216 no 1806 0.471257327753777 2548 2991039
SGTC_989 1501-0895 10.3 µM -0.0723111575915361 0.470356448135805 no 1807 0.471177142734616 2516 2830112
SGTC_139 0099-0334 718.624 µM -0.0725663872750732 0.470258545432111 no 1808 0.471075587621678 2540 97690
SGTC_2812 7970281 58.44 µM -0.0729491864883743 0.470111712129684 no 1809 0.470923276509845 2607 2233435
SGTC_1046 2001-0062 216 µM -0.0740785748728645 0.469678527509479 no 1810 0.470473931593305 2548 739778
SGTC_9 0092-0002 10.449 µM -0.0755216311730712 0.46912508570797 no 1811 0.469899843747029 2554 759368
SGTC_1410 3909-8106 77.9 µM -0.0765838728799659 0.468717732199471 no 1812 0.469477294423798 2581 1039210
SGTC_1973 st070275 50.2 µM -0.0772013541641945 0.468480952559337 no 1813 0.469231682198306 2508 17118334
SGTC_2156 5649887 115 µM -0.0775090852892635 0.468362954006532 no 1814 0.469109282001371 2638 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_596 1155-0152 116 µM -0.0776369357074608 0.468313930973793 no 1815 0.469058430296323 2547 280313
SGTC_945 3381-0768 11.3 µM -0.0781398811473161 0.468121085975175 no 1816 0.468858391796131 2555 1126236 YIL048W NEO1
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0795837107002617 0.467567518323127 no 1817 0.468284175548499 2582 6857784
SGTC_2333 9017922 200 µM -0.0802809719314923 0.467300209114985 no 1818 0.468006895779922 2642 3163164
SGTC_1031 k035-0009 16 µM -0.0803217821416018 0.467284564150421 no 1819 0.467990667269321 2643 5180959
SGTC_2270 7924575 90.91 µM -0.0809360783949457 0.467049074224041 no 1820 0.467746393830666 2711 1262135
SGTC_1127 asiatic acid 681.4 nM -0.0813847975303456 0.466877065424167 no 1821 0.467567969408112 2556 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2576 guaiol 23.12 µM -0.0815001744428863 0.466832838658101 no 1822 0.467522093078175 2686 227829
SGTC_287 k060-0039 29.6 µM -0.0815007206007832 0.466832629303519 no 1823 0.467521875915131 2600 5861974
SGTC_1465 k213-0056 144 µM -0.0815536566538441 0.466812337769684 no 1824 0.467500827552665 2533 24048857 YMR208W ERG12
SGTC_408 cantharidin 100 µM -0.0819312237904821 0.466667610626429 no 1825 0.467350702452756 2609 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1294 1000-1494 117 µM -0.0822349236049236 0.466551201132327 no 1826 0.467229951231242 2553 712797 YDL207W GLE1
SGTC_255 tunicamycin 200.472 nM -0.0824922007020528 0.466452587911219 no 1827 0.467127660067952 2576 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0838604790937802 0.465928167349093 no 1828 0.466583680972972 2732 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_515 4092-1064 102 µM -0.0849623833373768 0.465505883064681 no 1829 0.4661456481419 2598 717353
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0863094135199844 0.464989711635496 no 1830 0.465610227747831 2550 77254
SGTC_378 3970-0959 8.33 µM -0.0893627355188284 0.463819921964024 no 1831 0.464396818847915 2662 6615653
SGTC_1753 st043925 64 µM -0.0900584888216735 0.463553408127072 no 1832 0.464120368122342 2579 670181
SGTC_2431 5490079 200 µM -0.0908632508091535 0.463245158054576 no 1833 0.463800625482563 2605 5722345
SGTC_1351 1496-0003 46.5 µM -0.0927722891226772 0.462514022751313 no 1834 0.46304223306098 2632 3891978
SGTC_959 1222-0044 107 µM -0.0935467977039758 0.462217432633249 no 1835 0.462734586734867 2586 6083612
SGTC_2821 7996764 71.43 µM -0.0935517750274115 0.462215526686043 no 1836 0.462732609739865 2650 2987135
SGTC_1027 k015-0025 8.67 µM -0.0951624073861434 0.461598819278874 no 1837 0.462092914497203 2561 3598955
SGTC_802 4112-3352 742 µM -0.0952194905008804 0.461576963971505 no 1838 0.46207024457195 2724 704594
SGTC_1794 st048918 76.9 µM -0.0980498838579596 0.46049344330479 no 1839 0.460946341287212 2552 672303
SGTC_1476 4112-3294 3.34 µM -0.0991548772651515 0.460070512987981 no 1840 0.460507650481782 2694 704369
SGTC_2078 5212016 200 µM -0.0997646026204339 0.459837163178637 no 1841 0.4602656054114 2556 1899708
SGTC_3152 9099253 49.47 µM -0.100785239634561 0.459446583142364 no 1842 0.459860472119435 2657 25236131
SGTC_1901 st060216 58.6 µM -0.102766329519357 0.458688566539006 no 1843 0.459074214444893 2591 688792
SGTC_2765 myclobutanil 7.74 µM -0.10394989216825 0.458235776125405 no 1844 0.458604556655262 2683 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_896 0964-0007 44.5 µM -0.108569706639245 0.456468917765585 no 1845 0.45677189464266 2570 6756758
SGTC_3203 9113543 49.47 µM -0.109548034788935 0.456094863190763 no 1846 0.456383912368322 2755 17018012
SGTC_2249 haloperidol 116.36 µM -0.109766296283819 0.456011418255949 no 1847 0.456297360576892 2592 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_148 3253-0744 288.01 µM -0.109929935223638 0.455948857688613 no 1848 0.456232470768506 2577 6893655
SGTC_916 4466-0038 42 nM -0.110961053281364 0.455554677614257 no 1849 0.45582361546803 2630 5722064 YGL116W CDC20
SGTC_2567 aureobasidin a 60 nM -0.111120572798508 0.455493699731536 no 1850 0.455760367518161 2847 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2364 9055074 200 µM -0.111293138869267 0.455427735857795 no 1851 0.455691947998081 2659 6470630
SGTC_2420 aureobasidin a 50 nM -0.111622399948008 0.455301878279964 no 1852 0.455561405212273 2893 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_414 piperonyl butoxide 100 µM -0.1142185903532 0.4543096621137 no 1853 0.454532257689066 2607 5794 A potent inhibitor of cytochrome P450.
SGTC_2307 7538926 6.34 µM -0.114224017528223 0.454307588243758 no 1854 0.454530106637209 2667 96582
SGTC_706 4262-0057 46.9 µM -0.114804097522398 0.454085931227118 no 1855 0.454300200590409 2592 883298
SGTC_743 1275-0778 158 µM -0.115720188828961 0.45373590854208 no 1856 0.453937152687016 2714 2849257 YMR203W TOM40
SGTC_56 0957-0365 83.25 µM -0.117194819815921 0.453172553067538 no 1857 0.453352835910445 2594 6752360
SGTC_2598 perillyl alcohol 100 µM -0.118016535945426 0.452858672440478 no 1858 0.453027277828302 2739 10819 An apoptosis inducer.
SGTC_2528 xanthyletin 44.79 µM -0.118252737273533 0.452768453267416 no 1859 0.452933702375296 2646 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1733 st037357 54.9 µM -0.119414048833613 0.452324915662481 no 1860 0.452473665787791 2613 1272339 YGL099W LSG1
SGTC_2318 6029776 164 µM -0.122206764132196 0.451258543592999 no 1861 0.451367634803688 2725 818325
SGTC_11 0438-0307 1.3 µM -0.122808779618824 0.451028715451648 no 1862 0.451129260880858 2714 4011476
SGTC_2875 9039966 71.43 µM -0.123352939197592 0.450820988765718 no 1863 0.450913810732462 2727 6463691
SGTC_2558 carylophyllene oxide 100 µM -0.123615090965265 0.450720920135245 no 1864 0.450810021636678 2605 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1617 st002906 78 µM -0.12366716904992 0.450701041250037 no 1865 0.450789403685301 2625 5150859
SGTC_3108 9121785 49.47 µM -0.123876018149123 0.450621322063556 no 1866 0.450706720708411 2562 17140271
SGTC_115 0527-0192 112.043 µM -0.12402022181161 0.450566279662382 no 1867 0.450649631990014 2690 4233931
SGTC_550 4123-0385 25.7 µM -0.124572421108361 0.450355514514647 no 1868 0.450431031527295 2636 5731123
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.127997893459334 0.44904838462554 no 1869 0.4490753200526 2613 688667
SGTC_2727 riluzole 51.77 µM -0.128600429107519 0.448818519130623 no 1870 0.448836913374908 2632 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2433 5607874 27.82 µM -0.131254125277925 0.447806347682471 no 1871 0.44778714023969 2628 2252428
SGTC_2255 7941087 197.44 µM -0.132485465511465 0.447336805513816 no 1872 0.447300159263441 2740 935561
SGTC_3254 9136651 49.47 µM -0.133208731643573 0.447061039623229 no 1873 0.447014152769053 2641 16454030
SGTC_2088 5278280 127.392 µM -0.135102433886801 0.446339133068874 no 1874 0.446265442929966 2708 791502
SGTC_1134 3477-0009 42.5 µM -0.135684955491771 0.446117103099196 no 1875 0.44603517074976 2892 3973534
SGTC_1525 8-methoxypsoralen 92.5 µM -0.136934625607638 0.445640844429147 no 1876 0.445541234671987 2764 4114 Related to psoralen; DNA damaging agent.
SGTC_2162 5663267 200 µM -0.137101414988575 0.445577285660484 no 1877 0.445475317016353 2676 6456493
SGTC_938 3126-1755 342 µM -0.137777797165919 0.445319549682311 no 1878 0.445208016142366 2673 1777771
SGTC_365 0121-0052 13.6 µM -0.137822794721438 0.445302404145885 no 1879 0.44519023434752 2761 3101739
SGTC_3226 9131256 49.47 µM -0.138194738544118 0.445160685337993 no 1880 0.445043256617348 2631 17178073
SGTC_1821 st053465 65.6 µM -0.139112927738005 0.444810865026447 no 1881 0.444680456350935 2737 675086
SGTC_2756 carbadox 75.1 µM -0.139316876565452 0.444733168517491 no 1882 0.444599877180311 2694 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1078 idebenone 36.1 µM -0.13974456197851 0.444570244038001 no 1883 0.444430908232442 2723 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_54 0159-0055 9 µM -0.139972322388082 0.444483483743175 no 1884 0.444340929304047 2791 3319099
SGTC_3068 9116768 49.47 µM -0.140696112847087 0.444207789439948 no 1885 0.444055008024009 2741 41904888
SGTC_2207 7258803 200 µM -0.141903220526639 0.443748058041733 no 1886 0.443578225225063 2735 3666799
SGTC_612 0302-0167 22.4 µM -0.141998873619834 0.44371163143807 no 1887 0.443540447696228 2731 235821
SGTC_1145 3546-0597 10.2 µM -0.14229657091661 0.443598265420944 no 1888 0.443422877489017 2703 875334
SGTC_2707 st078556 66.6 µM -0.143149348731969 0.443273544940918 no 1889 0.443086115790329 2737 17250899
SGTC_1815 st051655 58.2 µM -0.143610872674139 0.443097821865274 no 1890 0.442903877255176 2673 5984156
SGTC_1426 4048-4480 71.7 µM -0.144113592580079 0.442906426354765 no 1891 0.442705385720359 2734 14224343
SGTC_3305 9127027 53.8275 µM -0.14478813820776 0.442649634297651 no 1892 0.44243907393654 2716 41905295
SGTC_2687 chenodiol 100 µM -0.147366158233422 0.441668433503001 no 1893 0.441421507834314 2745 5702181 A cholesterol synthesis inhibitor.
SGTC_3281 9140613 49.47 µM -0.1476606803351 0.441556360326414 no 1894 0.441305281969635 2702 16013766
SGTC_1967 st070177 51.4 µM -0.148786600125221 0.441127962321236 no 1895 0.440861012246208 2814 5729214
SGTC_1210 3013-0140 750 nM -0.148958590950798 0.441062528075087 no 1896 0.440793153989026 2832 905973
SGTC_1950 st077106 7.18 µM -0.149470960390927 0.440867605661744 no 1897 0.440591011091853 2760 13831864
SGTC_2820 7989630 71.43 µM -0.149667525941144 0.440792829374043 no 1898 0.440513465042078 2695 2984098
SGTC_1372 2752-0194 270 µM -0.150067872859195 0.440640538331597 no 1899 0.44035553332599 2666 823334
SGTC_2979 9012552 45.46 µM -0.150254063906811 0.440569714676906 no 1900 0.440282086580573 2742 17100905
SGTC_1816 st051957 91.6 µM -0.150488982044524 0.440480358844887 no 1901 0.440189421401624 2678 674121
SGTC_2041 5107442 45.335 µM -0.151621617324578 0.440049580880878 no 1902 0.43974269118705 2756 793005
SGTC_323 4013-0906 34.3 µM -0.152623793607801 0.439668479860123 no 1903 0.439347480121764 2792 2910086
SGTC_2913 7966556 36.57 µM -0.153568441658069 0.439309306470911 no 1904 0.438975010812044 2683 2976516
SGTC_1224 0823-0416 294 µM -0.154134261812848 0.439094194651045 no 1905 0.438751937021834 2791 3598164
SGTC_225 nsc-122657 1.016 µM -0.15516689452369 0.438701657834173 no 1906 0.438344873245066 2788 275685
SGTC_2783 7738165 71.43 µM -0.155938882182631 0.438408239922074 no 1907 0.438040598318599 2742 17201110
SGTC_822 1487-0950 154 µM -0.157440287979392 0.437837681050623 no 1908 0.437448932069097 2702 1958375
SGTC_2389 9091542 195.52 µM -0.157665631130532 0.437752058073902 no 1909 0.437360142040441 2747 3626624 YOL127W RPL25
SGTC_3296 9122258 64.045 µM -0.157694013591059 0.437741273880142 no 1910 0.437348958966602 2785 4730474
SGTC_2141 5621638 7.665 µM -0.157878422682029 0.437671206967225 no 1911 0.437276300506724 2812 2856238
SGTC_2173 5763948 167 µM -0.15915225334002 0.437187263812578 no 1912 0.436774460302633 2673 2867177
SGTC_1484 3473-2379 286 µM -0.16071241906759 0.436594666712673 no 1913 0.436159953793137 2691 671917
SGTC_2004 4023728 41.89 µM -0.162187913999519 0.436034360955995 no 1914 0.435578938510881 2772 360084 YDR527W RBA50
SGTC_2946 9065502 71.43 µM -0.16253187226472 0.435903764345014 no 1915 0.435443515753375 2675 16489101
SGTC_2148 5546263 113.568 µM -0.163257212124843 0.435628384882163 no 1916 0.435157960812745 2685 792097
SGTC_2379 9035213 200 µM -0.163264865022367 0.435625479581613 no 1917 0.43515494816687 2732 646551
SGTC_129 0088-0017 176.636 µM -0.163313275651051 0.435607101338659 no 1918 0.435135890886562 2727 182446
SGTC_2769 toremifene 3.73 µM -0.164975516379672 0.43497614553805 no 1919 0.434481626538933 2868 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1155 4088-0394 48.2 µM -0.166035956599972 0.434573708455921 no 1920 0.434064326805052 2681 2326248
SGTC_1786 berberine 21.6 µM -0.166183121815985 0.434517864600547 no 1921 0.434006420796692 2692 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.166222660751073 0.434502861233101 no 1922 0.433990863408494 2825 5024745
SGTC_3064 1327-0027 10 µM -0.167002107017211 0.43420711335406 no 1923 0.433684195524376 2700 16000455 YPR107C YTH1
SGTC_2962 9082311 13.18 µM -0.167005015682489 0.434206009778415 no 1924 0.433683051204254 2704 16459453
SGTC_1939 st074455 53.6 µM -0.168767577819218 0.433537371323649 no 1925 0.432989730807289 2942 1644229
SGTC_3024 9090631 49.47 µM -0.169798828031093 0.433146248466466 no 1926 0.432584174320487 2719 25236383
SGTC_473 2-arachidonoylglycerol 10 µM -0.170231809142441 0.432982050966958 no 1927 0.432413918359215 2675 5282280 An endocannabinoid.
SGTC_657 3534-0529 86.7 µM -0.170823533600505 0.432757672649973 no 1928 0.432181261957748 2862 1049549
SGTC_2583 asiatic acid 100 µM -0.172964669307276 0.431945948673414 no 1929 0.431339599407948 2856 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_124 0136-0217 7.121 µM -0.174446660913473 0.431384280199712 no 1930 0.430757223172806 2777 3976905
SGTC_1650 st011916 45.8 µM -0.175331060547938 0.43104916254053 no 1931 0.430409753491185 2765 242528
SGTC_2850 9015429 58.44 µM -0.175429286306572 0.43101194578871 no 1932 0.430371165124391 2780 6457570
SGTC_1242 0402-0103 60.1 µM -0.176108899290137 0.430754464065143 no 1933 0.430104194787222 2711 432868
SGTC_2983 9022671 12.99 µM -0.176605857423762 0.430566202535414 no 1934 0.429908996425965 2934 6405161
SGTC_1496 4469-0713 57.4 µM -0.177614440850487 0.430184171702826 no 1935 0.429512891357359 2805 746691
SGTC_924 2046-0044 21.3 µM -0.177845830937603 0.430096535059605 no 1936 0.429422026579923 2703 3623589
SGTC_2359 9039622 200 µM -0.178127045117086 0.429990032683954 no 1937 0.429311601369715 2720 6463596
SGTC_1009 4106-0057 9.87 µM -0.178443416063904 0.429870221708873 no 1938 0.429187377659039 2719 2928005
SGTC_3313 9133968 57.047 µM -0.17847101895513 0.429859768686901 no 1939 0.429176539658798 2690 1494643
SGTC_1797 st048695 56.8 µM -0.178749298743043 0.429754388823926 no 1940 0.429067278856258 2859 592262 YIL048W NEO1
SGTC_2279 7948423 32.93 µM -0.179687580290622 0.429399114350779 no 1941 0.428698922117258 2796 1247112
SGTC_140 0062-0056 502.533 µM -0.181206050034984 0.428824276485138 no 1942 0.428102922987517 2689 3758964
SGTC_1715 st032160 10.2275 µM -0.181496900863532 0.428714188041696 no 1943 0.42798878275484 2818 5289825
SGTC_504 lovastatin 124 µM -0.182528423093072 0.428323796667019 no 1944 0.427584025303411 2739 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1428 4049-0204 61.7 µM -0.183233351097494 0.428057048926447 no 1945 0.427307463473146 2826 X1428
SGTC_974 1326-0144 138 µM -0.184576782965663 0.427548779739966 no 1946 0.426780498768667 2744 5411856
SGTC_755 1995-0008 37.3 µM -0.185441385918563 0.427221732493453 no 1947 0.426441425015862 2719 689533
SGTC_699 0375-0592 111 µM -0.185445594771266 0.427220140562639 no 1948 0.426439774551109 2766 762578
SGTC_2919 7978188 46.38 µM -0.185883912862502 0.427054360290576 no 1949 0.426267899005795 2848 2980291
SGTC_3046 9092212 49.47 µM -0.186017605425578 0.427003797772839 no 1950 0.426215477575529 2716 25236637
SGTC_1509 1326-1131 80 µM -0.187204797405112 0.426554854554831 no 1951 0.425750031775306 2732 768313
SGTC_828 2074-0507 139 µM -0.187245529952128 0.426539453001571 no 1952 0.425734064165399 2875 X828
SGTC_3333 9141820 12.094 µM -0.187669701798877 0.42637907427649 no 1953 0.425567791342162 2772 1939433
SGTC_220 paclitaxel 373.376 µM -0.191181941332937 0.42505157202012 no 1954 0.424191525695267 2857 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2611 pyromycin 23.93 µM -0.191583746689811 0.424899757677151 no 1955 0.424034137466408 2780 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2187 6125751 200 µM -0.192076767812732 0.424713494449703 no 1956 0.423841036334334 2793 874498
SGTC_2779 methotrexate 400 µM -0.192162304877512 0.424681180283124 no 1957 0.423807535970597 2770 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1691 st019933 84.6 µM -0.196168093657946 0.423168445136813 no 1958 0.422239300205292 2733 6176082
SGTC_1175 0741-0056 27.6 µM -0.196735796648752 0.42295415039518 no 1959 0.422017147912786 2938 765927
SGTC_2034 5197015 53.07 µM -0.19694863243654 0.422873815682181 no 1960 0.421933867868566 2897 780676
SGTC_1661 st013063 9.66 µM -0.199492621968525 0.421913837878685 no 1961 0.420938707091725 2765 721395
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.200041121758611 0.421706921343958 no 1962 0.420724210263758 2862 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2395 5646831 180.19 µM -0.200439361018854 0.4215567027616 no 1963 0.420568489198377 2916 6808628
SGTC_1103 duloxetine 36.1 µM -0.201097902183194 0.421308321570236 no 1964 0.42031101115211 2932 60835 A selective serotonin reuptake inhibitor.
SGTC_444 curcumin 90.4 µM -0.201310502665661 0.421228141979127 no 1965 0.420227895367191 2891 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_153 4077-0274 519.67 µM -0.203603505942713 0.420363572988583 no 1966 0.419331676594238 3018 3121976
SGTC_1475 4092-1048 11.7 µM -0.204062712677073 0.420190476697203 no 1967 0.419152246084523 2838 2881759
SGTC_190 3970-0790 3.722 µM -0.20526692134546 0.419736628057694 no 1968 0.418681793353432 2759 2832352
SGTC_1998 st075797 76.8 µM -0.206897449619776 0.419122275999739 no 1969 0.418044974167268 2725 24208315
SGTC_311 1315-0136 58 µM -0.207237481588025 0.418994183211493 no 1970 0.41791219828223 2927 6759207
SGTC_2284 7945075 39.21 µM -0.211382272283878 0.417433501264308 no 1971 0.416294494441083 2922 1245402
SGTC_1336 1486-0901 104 µM -0.211558247133797 0.417367268182372 no 1972 0.416225842959283 2854 5006114
SGTC_2730 imipramine 71.33 µM -0.213295961540581 0.416713356689068 no 1973 0.415548061653043 2790 3696 A tricyclic antidepressant.
SGTC_2048 5246248 200 µM -0.213743675009298 0.416544916900714 no 1974 0.415373475287364 2849 677046
SGTC_3186 9110464 49.47 µM -0.214210070706466 0.416369464736932 no 1975 0.415191621533028 2902 17018021
SGTC_942 3253-1115 227 µM -0.214967292653443 0.416084642916224 no 1976 0.414896409546653 2958 46497897
SGTC_1559 coumarin 343 70.1 µM -0.216131270915592 0.415646909561704 no 1977 0.414442712526161 2940 108770 A hepatotoxic, DNA x-linker.
SGTC_525 k781-2675 26.7 µM -0.216522030673303 0.41549998130225 no 1978 0.414290427217583 2789 3651118 YDL195W SEC31
SGTC_2725 haloperidol 53.21 µM -0.217339468731295 0.415192657402775 no 1979 0.413971900264963 2796 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_782 0083-0095 30.5 µM -0.217607623659306 0.41509185320526 no 1980 0.413867422006647 2752 3591729 An indicator and reagent.
SGTC_226 1,3-diallylurea 8.28947 mM -0.217688868114076 0.415061313075503 no 1981 0.413835768825397 2876 74537 YKL182W FAS1
SGTC_2349 9023730 187.07 µM -0.218635562644727 0.414705484530839 no 1982 0.413466973974076 2931 4126287
SGTC_141 0443-0274 32.331 µM -0.220225185438943 0.41410815982756 no 1983 0.4128478914682 2917 1627241
SGTC_1929 genistein trimethyl ether 50.5 µM -0.220856792728505 0.413870878940698 no 1984 0.412601970526079 2966 136420
SGTC_2840 9008771 71.43 µM -0.222010265482663 0.41343762594292 no 1985 0.412152946019164 2951 2992978
SGTC_2005 4024620 188 µM -0.222670107272429 0.413189831776248 no 1986 0.411896134105344 2790 236743
SGTC_1355 1499-0035 1.68 µM -0.223210352253738 0.412986976224296 no 1987 0.411685897626269 2796 1548538
SGTC_3077 9117319 49.47 µM -0.224200261645367 0.412615337365663 no 1988 0.41130073994539 2775 17154678
SGTC_1324 1418-0026 34.4 µM -0.225563507422121 0.412103666155929 no 1989 0.410770463111563 2906 1372513
SGTC_2371 9071574 200 µM -0.226258830656743 0.411842745830085 no 1990 0.410500058244699 2897 45596039
SGTC_133 0724-0033 378.92 µM -0.228464950424186 0.411015157008813 no 1991 0.409642400560965 2765 280309
SGTC_161 4065-0411 162.148 µM -0.228962898779216 0.410828414670592 no 1992 0.409448876317424 2944 1906281 YLR208W SEC13
SGTC_988 1497-1057 103 µM -0.229886228506173 0.410482197828154 no 1993 0.409090088913796 2807 3533044
SGTC_992 3909-8734 162 µM -0.230649124136457 0.410196190854226 no 1994 0.408793700419127 2863 4288319
SGTC_193 1273-0060 1.558 µM -0.230657825687543 0.410192928947559 no 1995 0.408790320126609 2800 2847393 YHR072W ERG7
SGTC_1625 st003711 30.1 µM -0.231444012159023 0.409898240850126 no 1996 0.408484938208372 3023 24207034 YER133W GLC7
SGTC_3187 9109394 49.47 µM -0.234098105865807 0.408903777534112 no 1997 0.407454408191607 2856 17098090
SGTC_3265 9137266 49.47 µM -0.234109665900071 0.408899447378181 no 1998 0.407449921063042 2834 17224265
SGTC_1415 3966-0071 78.1 µM -0.234132119478807 0.40889103675174 no 1999 0.407441205544464 2821 2893185
SGTC_721 1187-1332 279 µM -0.234953370031184 0.408583442861461 no 2000 0.407122462736463 2766 25730
SGTC_928 2764-0428 58.7 µM -0.236010278708517 0.408187667682822 no 2001 0.40671234709914 2947 662578
SGTC_3131 9127911 49.47 µM -0.236092761727501 0.408156784623356 no 2002 0.406680345248037 3066 45595681
SGTC_2310 7668677 200 µM -0.236626997902741 0.407956771243011 no 2003 0.406473086816506 3041 2197143
SGTC_2373 9071805 200 µM -0.239678137534862 0.406814912233143 no 2004 0.405289892358085 2962 10149009
SGTC_1424 4048-1941 275 µM -0.239757482333083 0.406785228743015 no 2005 0.405259134914206 2946 X1424
SGTC_2487 5918373 44.05 µM -0.239931227897389 0.40672023108158 no 2006 0.405191785731806 2844 2876279
SGTC_606 k015-0008 38.6 µM -0.240075118205081 0.406666404121518 no 2007 0.405136011500309 2971 1970475
SGTC_2720 fluspirilene 36.88 µM -0.240534735628943 0.406494480738945 no 2008 0.404957869197348 2925 3396 An atypical antipsychotic.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.240638068111599 0.406455830920625 no 2009 0.404917821453666 2830 368090
SGTC_1762 st045503 25.4615 µM -0.241677952139403 0.406066930170128 no 2010 0.404514857422358 2917 4645554
SGTC_1320 1313-0481 95.3 µM -0.242393254335917 0.405799471839814 no 2011 0.404237730408195 2983 6813365 YLR208W SEC13
SGTC_1414 3917-0015 5.4 µM -0.243564992020423 0.405361442968955 no 2012 0.40378387207305 2886 6618702
SGTC_3173 9105693 49.47 µM -0.244218891913849 0.405117048076372 no 2013 0.40353064817195 3005 17096658
SGTC_1578 josamycin 24.2 µM -0.244351927614896 0.405067330548491 no 2014 0.403479134806025 2846 5282165 A P450 substrate.
SGTC_170 4197-0004 226 µM -0.244365495918918 0.405062259946573 no 2015 0.403473881054683 2977 218692
SGTC_2744 captopril 92.04 µM -0.244441734277055 0.405033769256595 no 2016 0.403444361301854 2924 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1672 st016598 6.51 µM -0.244789501541241 0.404903813121293 no 2017 0.403309711609192 2890 4665860 YNL267W PIK1
SGTC_394 menadione 8.33 µM -0.244857531463342 0.404878392443956 no 2018 0.403283372896331 2951 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_846 0335-0850 148 µM -0.245073381681212 0.404797738552849 no 2019 0.403199806443396 2856 6819598
SGTC_624 k048-0052 28 µM -0.245829950513173 0.404515073454123 no 2020 0.402906935601067 2889 6835531
SGTC_3137 9097352 49.47 µM -0.246244065894292 0.404360375028374 no 2021 0.402746652923894 3148 44120435
SGTC_264 promethazine 12.5 mM -0.246320175639537 0.40433194482504 no 2022 0.40271719654934 2864 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2291 7917025 104.35 µM -0.246457962839647 0.40428047677346 no 2023 0.402663870862413 2829 2964612
SGTC_493 zm226600 134 µM -0.246703128328452 0.404188903495693 no 2024 0.402568992665733 3026 5240098 A potassium channel opener. YCR052W RSC6
SGTC_111 0083-0039 52.457 µM -0.247139870515703 0.404025786229099 no 2025 0.402399989168843 2811 759313
SGTC_2071 5230951 39.92 µM -0.247740117024673 0.40380162955383 no 2026 0.402167745156432 2891 1799272
SGTC_1116 jasmonic acid 1.58368 µM -0.247933445759237 0.403729439394143 no 2027 0.402092950835549 3005 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2024 5144227 134 µM -0.248074109061472 0.40367691689745 no 2028 0.402038533779418 2999 3475211
SGTC_3237 9133362 49.47 µM -0.248301700322989 0.403591939909324 no 2029 0.401950491763492 2963 43845137
SGTC_1152 3909-8331 15.9 µM -0.248693863134332 0.403445526624954 no 2030 0.401798798121214 2857 16001939
SGTC_1319 1306-0155 43.7 µM -0.249981007662226 0.402965068715589 no 2031 0.401301018065991 2843 3122360
SGTC_3011 9081274 71.4286 µM -0.250358408655941 0.40282422238023 no 2032 0.401155095328586 2876 6625322
SGTC_613 3914-0030 117 µM -0.250616088434741 0.402728063335376 no 2033 0.401055470922066 2787 1145395
SGTC_2861 9024595 19.48 µM -0.251156068918467 0.402526576480218 no 2034 0.400846724016323 2893 16482810
SGTC_1633 st005664 67.9 µM -0.252163604397999 0.402150696679992 no 2035 0.400457304348727 2821 2063822
SGTC_2520 obtusaquinone 4.71 µM -0.252252266372402 0.4021176240117 no 2036 0.400423040591888 3017 5967872
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.252939376991904 0.401861341951218 no 2037 0.400157530083034 2871 6708514
SGTC_1879 gemcitabine 100 µM -0.254304281608085 0.401352378050623 no 2038 0.399630246134644 2863 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1893 st059353 36.1 µM -0.25461454328717 0.401236706833799 no 2039 0.399510412699962 2912 3112488
SGTC_3224 9130643 49.47 µM -0.255634914954562 0.400856354745753 no 2040 0.399116377859784 3056 17644395
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.256127961955824 0.400672600994384 no 2041 0.398926015710122 2881 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2869 9037858 32.47 µM -0.258420809035074 0.399818368881561 no 2042 0.398041079292519 2821 27187042
SGTC_3165 9101544 49.47 µM -0.260286832093804 0.399123509511809 no 2043 0.397321264556378 2971 5002184
SGTC_839 0122-0028 230 µM -0.260931411920343 0.398883558568691 no 2044 0.39707270025597 2880 759448
SGTC_2021 4019055 173 µM -0.261433888239582 0.398696533499437 no 2045 0.396878963214828 3009 44827708 YER133W GLC7
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.261558705018333 0.398650079458946 no 2046 0.396830842237475 2884 115019
SGTC_2602 kawain 100 µM -0.266529110647048 0.396801378240365 no 2047 0.394915871448394 2849 5369129
SGTC_3197 9113331 49.47 µM -0.266763790755662 0.396714147877228 no 2048 0.394825517506368 3092 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2793 7325131 81.82 µM -0.268261551515418 0.396157553620056 no 2049 0.394248999651552 2942 4176441
SGTC_1759 st043059 70 µM -0.269380250658831 0.395741963318946 no 2050 0.39381854116427 2884 669426
SGTC_865 0488-0499 301 µM -0.269656899336393 0.395639208183434 no 2051 0.393712110926952 2995 9634651
SGTC_2328 6201408 200 µM -0.270209206928316 0.395434087240905 no 2052 0.393499654981521 3007 2890418
SGTC_1803 st050068 52.4 µM -0.270437607044741 0.395349270421567 no 2053 0.393411805660995 2901 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2684 capsaicin 100 µM -0.271504881467501 0.394953001791144 no 2054 0.393001372897228 2974 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1076 itraconazole 331 nM -0.272080013533399 0.394739505856573 no 2055 0.392780248465841 2862 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1020 4335-0961 93.3 µM -0.272991646574096 0.394401161495278 no 2056 0.392429818425536 2837 669075
SGTC_2659 sanguinarine 24.21 µM -0.273279675374273 0.394294278757365 no 2057 0.392319118806898 2877 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2439 5492030 7.2 µM -0.273522566538528 0.39420415203723 no 2058 0.392225773944055 3009 5722370
SGTC_1401 3807-4679 7.6 µM -0.275567259901819 0.393445677116183 no 2059 0.391440229557356 2882 3291456
SGTC_1819 st053448 58.6 µM -0.27688962663407 0.392955362851498 no 2060 0.390932429027782 2919 2857616
SGTC_3125 9127534 49.47 µM -0.277047482376393 0.392896843577138 no 2061 0.390871823429576 2933 1639235
SGTC_2329 6138490 200 µM -0.277078937219162 0.392885183127555 no 2062 0.390859747279855 3130 720019
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.277466682864092 0.392741451997635 no 2063 0.390710892540647 2865 16486 A toxic proline analog.
SGTC_1772 st048439 82.2 µM -0.279331819310113 0.392050280347306 no 2064 0.389995094720932 2988 2927068 YDL195W SEC31
SGTC_2428 5615643 7.78 µM -0.279560716897373 0.391965480195571 no 2065 0.389907274564824 3026 2253075
SGTC_385 1494-0393 12.4 µM -0.279863975017176 0.391853139450658 no 2066 0.389790933477046 2941 3090647
SGTC_2052 5265182 7.135 µM -0.280358751994133 0.39166987067832 no 2067 0.38960113983663 3055 1239884
SGTC_1466 k213-0079 57.5 µM -0.282157054677362 0.391003969827236 no 2068 0.388911543171164 2895 3657981
SGTC_1048 3161-0300 24.5 µM -0.282718990280087 0.390795953807124 no 2069 0.388696128883397 2901 2165101
SGTC_1315 1237-0019 3.69 µM -0.282929130949672 0.390718172444431 no 2070 0.388615581638765 3019 825140
SGTC_2849 9019321 12.99 µM -0.283494228379833 0.390509029259635 no 2071 0.388399002680155 3029 16489627
SGTC_1909 st060837 51.5 µM -0.284959875931203 0.389966739235568 no 2072 0.387837441170002 2960 678937
SGTC_3198 9112019 49.47 µM -0.286045382008454 0.389565239603293 no 2073 0.38742168160102 2895 45595555
SGTC_3287 9117173 37.0625 µM -0.286592096614063 0.389363069102862 no 2074 0.387212333344029 2970 2789709
SGTC_2413 inermin 26.06 µM -0.287354136570597 0.389081323048531 no 2075 0.386920587317838 3202 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_350 k064-0020 19.8 µM -0.287511791733622 0.389023041096642 no 2076 0.386860237209255 3113 2790705
SGTC_3015 9080845 49.47 µM -0.288205234313643 0.388766718945758 no 2077 0.386594821151083 3049 5296973
SGTC_1648 st011736 69.8 µM -0.288477083408873 0.388666246621039 no 2078 0.386490785018507 3069 2855514
SGTC_1113 artemisinin 1.17947 µM -0.288737450632438 0.38857002484704 no 2079 0.386391150625155 3013 2240 An anti-malaria and mitochondrial poison.
SGTC_2478 5763493 32.33 µM -0.290512607074907 0.387914177374976 no 2080 0.385712053708025 2915 1365576 YLR208W SEC13
SGTC_854 0422-0053 192 µM -0.290920870265497 0.387763386013375 no 2081 0.385555919586573 2935 3596728
SGTC_2534 helenine 20.12 µM -0.293658580688543 0.386752655348654 no 2082 0.384509403642477 2872 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1306 1185-0270 9.02 µM -0.293745565279496 0.386720554201703 no 2083 0.384476166699414 3037 1548076
SGTC_2807 7945238 51.95 µM -0.296521278851232 0.385696601670513 no 2084 0.383416009538195 3026 17148797
SGTC_3219 9131112 49.47 µM -0.296587015645916 0.385672361182832 no 2085 0.383390912543767 3029 17612988 YMR079W SEC14
SGTC_3354 9151612 71.43 µM -0.299895919411133 0.384452779450159 no 2086 0.382128273499125 3059 27261949
SGTC_223 busulfan 5 mM -0.300024855530553 0.384405279777835 no 2087 0.382079098249892 3019 2478 A DNA alkylator.
SGTC_3266 9136860 49.47 µM -0.300243010556048 0.384324916086219 no 2088 0.381995899925151 3039 4871271 YPR165W RHO1
SGTC_556 4058-0063 51.5 µM -0.301862980205542 0.383728309332363 no 2089 0.381378258786183 2993 6615692
SGTC_3334 9142812 21.919 µM -0.302320683823018 0.383559794877386 no 2090 0.381203806098765 3054 45283678
SGTC_51 1013-0126 23.419 µM -0.302744480804893 0.383403783590056 no 2091 0.381042298369209 3219 1627850
SGTC_1826 st055655 41.6 µM -0.306135429856659 0.38215616503079 no 2092 0.379750766476739 3009 676168
SGTC_2098 5376439 882.5 nM -0.306448794416091 0.382040931556465 no 2093 0.379631480798513 3048 2844116
SGTC_1177 0983-0204 23.6 µM -0.306593226507744 0.381987823095283 no 2094 0.37957650498445 3104 766818
SGTC_1491 4138-0063 26.5 µM -0.306964134098831 0.381851448544215 no 2095 0.379435335973298 3034 23883227
SGTC_1583 clindamycin 39.6 µM -0.307172848118678 0.381774715441542 no 2096 0.379355905592489 2938 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.308618260719028 0.381243441326924 no 2097 0.378805964235908 2985 1241132 A phosphatase inhibitor.
SGTC_2369 9071472 200 µM -0.309315697522169 0.38098717225405 no 2098 0.378540695593841 3090 17296037
SGTC_1347 1493-0251 600 nM -0.310292776819832 0.380628237982849 no 2099 0.378169161768271 3093 3986378
SGTC_953 1188-0045 9.7 µM -0.310631631610516 0.380503782197344 no 2100 0.378040338720253 3058 6144426
SGTC_2490 carminic acid 95.39 µM -0.314842824712468 0.378958116013368 no 2101 0.37644049729057 2927 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_709 3807-1509 243 µM -0.31527699449272 0.37879886891708 no 2102 0.376275675350065 2977 1886677 YPL242C IQG1
SGTC_1508 1080-0625 72.9 µM -0.316827896551646 0.378230189009935 no 2103 0.375687097727765 2922 767111
SGTC_1655 st012546 55.1 µM -0.318401083778536 0.377653607030834 no 2104 0.375090358142149 3068 720985 YLR208W SEC13
SGTC_3352 9151559 45.5865 µM -0.318881582844141 0.377477555686688 no 2105 0.374908155298448 3044 17159339
SGTC_2795 7780010 54.55 µM -0.31898370664839 0.377440141550371 no 2106 0.374869434058131 3103 953673
SGTC_2341 7987486 176.74 µM -0.319926994565466 0.377094612459347 no 2107 0.374511836888146 3130 1258686
SGTC_780 0109-0199 192 µM -0.320779217325394 0.376782525389397 no 2108 0.37418885497301 3156 610414
SGTC_477 mead ethanolamide 10 µM -0.321058012732376 0.376680446963835 no 2109 0.374083214106522 2964 16061185
SGTC_1181 1222-0449 220 µM -0.321746147317271 0.376428529603314 no 2110 0.373822507350127 3153 658318
SGTC_1969 st069479 40.1 µM -0.322341279955195 0.376210701510808 no 2111 0.373597081861175 3150 3895485
SGTC_2176 5809774 33.9695 µM -0.323018563172686 0.375962852956099 no 2112 0.373340591826894 3095 2870539
SGTC_2593 nobiletin 86.24 µM -0.323498211909824 0.375787358731419 no 2113 0.37315898074208 3041 72344 An anti-infammatory.
SGTC_156 3474-0145 5.642 µM -0.324493854555612 0.375423154335467 no 2114 0.372782087066932 2996 2265471
SGTC_1920 st075728 45.7 µM -0.324865367056667 0.375287284110934 no 2115 0.372641484736995 3162 3400306
SGTC_948 3448-0295 75.3 µM -0.327056806871135 0.374486142062554 no 2116 0.371812459971057 2961 678569
SGTC_3145 9085516 49.47 µM -0.327429592403042 0.374349913699604 no 2117 0.371671493695888 3080 25236195
SGTC_58 0957-0393 9 µM -0.328398024949538 0.373996089237927 no 2118 0.37130536806365 3113 6997992
SGTC_2347 9049783 174.81 µM -0.330258436760681 0.373316671140947 no 2119 0.370602347640758 3146 6467988 YPL169C MEX67
SGTC_1137 ixabepilone 100 µM -0.331015293056537 0.373040381501983 no 2120 0.370316466972758 2949 154225 A novel microtubule stabilizer.
SGTC_516 3992-2719 87.3 µM -0.333028515200746 0.372305774876428 no 2121 0.369556379274952 2921 5350887 YDR037W KRS1
SGTC_1936 st074407 74.3 µM -0.333110743017351 0.372275780540517 no 2122 0.369525345149379 2995 809813
SGTC_2308 7584454 197.62 µM -0.335996819820792 0.371223515029539 no 2123 0.368436632312702 3182 893577
SGTC_2998 9066762 71.4286 µM -0.336272053064839 0.371123214926835 no 2124 0.368332861246869 3190 4945196
SGTC_2929 9013348 24.6 µM -0.336572769872836 0.371013638147332 no 2125 0.368219493103558 3088 2995952
SGTC_1016 4226-1401 38 µM -0.33665779110848 0.370982659556183 no 2126 0.368187442769722 3026 2901613
SGTC_3080 9117754 49.47 µM -0.337648678372231 0.370621678621575 no 2127 0.3678139771145 3222 9550191
SGTC_3279 9140807 49.47 µM -0.338145491069593 0.370440732240685 no 2128 0.367626775286988 3016 45595718
SGTC_1737 st035557 69.7 µM -0.339900546728089 0.369801745254122 no 2129 0.366965712449791 2994 5716916
SGTC_2404 5161160 200 µM -0.341182211827237 0.369335338912166 no 2130 0.366483206833338 2938 2831543
SGTC_1734 st037168 69.4 µM -0.341460553490995 0.369234073940417 no 2131 0.366378448020621 3091 708907
SGTC_166 k072-0058 166.424 µM -0.341839866914086 0.369096088500917 no 2132 0.366235702728855 3129 5846229
SGTC_314 1671-0008 2.74 µM -0.342181931145604 0.368971667917873 no 2133 0.366106991125867 3000 3913060
SGTC_2990 9074105 71.4286 µM -0.342532418442079 0.368844197815136 no 2134 0.365975125725715 3088 6502001
SGTC_310 1273-0058 1.06 µM -0.342767672863955 0.368758645300117 no 2135 0.365886623782177 3105 2734232
SGTC_3054 9094397 49.47 µM -0.342965228598522 0.368686807295956 no 2136 0.365812309473816 3032 2598354
SGTC_1867 st057372 64 µM -0.343628624113478 0.368445607644418 no 2137 0.365562797619439 3022 688837
SGTC_800 3448-7362 155 µM -0.344579003190146 0.368100155840928 no 2138 0.365205446563203 3092 15991913
SGTC_1147 3809-1045 12.3 µM -0.344931695702266 0.367971983304989 no 2139 0.365072860768432 3030 325925
SGTC_1380 2291-0730 164 µM -0.345186393500518 0.367879432319574 no 2140 0.364977123626631 3095 2999191
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.345526525885844 0.367755848444413 no 2141 0.364849286010973 3197 5393153
SGTC_1638 st008370 60.6 µM -0.346250108021189 0.367492987295495 no 2142 0.36457738008439 3017 24207134
SGTC_817 1391-0715 46 µM -0.346866339942365 0.36726917300549 no 2143 0.364345867660346 3056 1353946
SGTC_450 aminopyrene 156 nM -0.346887843685432 0.367261363699664 no 2144 0.364337789803266 3134 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1017 4239-0030 168 µM -0.346946008860737 0.367240240692165 no 2145 0.364315940422018 3029 1149593
SGTC_2060 5238662 140 µM -0.347115817979013 0.367178575863636 no 2146 0.364252155220594 3105 790130
SGTC_563 tetrahydrosecaminediol 614 µM -0.348084993832986 0.366826692992718 no 2147 0.363888176834662 3163 334274 A psychoactive constituent of the cannabis plant.
SGTC_457 grayanotoxin iii 135 µM -0.34857336037583 0.366649422010081 no 2148 0.363704815064675 3100 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1051 3253-3903 78 µM -0.349263121455807 0.366399095773505 no 2149 0.363445891019534 2966 5509239
SGTC_3243 9134147 49.47 µM -0.351567470519232 0.36556322023271 no 2150 0.362581332195811 3099 24282180
SGTC_546 peri-Naphthalide 147 µM -0.351923102108379 0.365434275784801 no 2151 0.36244796657009 3054 223824 A penicillin ester.
SGTC_2879 9041815 71.43 µM -0.352351471326619 0.365278978412488 no 2152 0.362287345721672 3118 4942971
SGTC_3043 9092303 49.47 µM -0.353100595327281 0.365007450402205 no 2153 0.362006513295361 3077 25236084
SGTC_2955 9076254 12.21 µM -0.355749351428445 0.364047923926685 no 2154 0.361014141239477 3134 16459619
SGTC_1659 st012954 42.1 µM -0.356191164485866 0.363887957433456 no 2155 0.360848704167459 3152 24207262
SGTC_2587 piperic acid 92.2 µM -0.356416344791718 0.363806435910934 no 2156 0.360764395327484 3076 5370536
SGTC_2202 7226349 200 µM -0.356994174672695 0.363597273664856 no 2157 0.360548083365262 3015 844334
SGTC_15 0266-0086 27.098 µM -0.357023858749551 0.363586529751525 no 2158 0.36053697226628 3135 1712902 YIL048W NEO1
SGTC_2839 9003951 25.97 µM -0.357040369167431 0.36358055398474 no 2159 0.360530792273706 3138 2990634
SGTC_753 1322-0200 289 µM -0.357163684111051 0.363535922527386 no 2160 0.360484635573317 3158 5403907
SGTC_3139 9095020 49.47 µM -0.357179558986881 0.363530177057851 no 2161 0.360478693765662 2922 25236292
SGTC_2515 chrysin 20.77 µM -0.357564731919507 0.363390783843794 no 2162 0.360334537708173 3115 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3065 9113888 49.47 µM -0.357844263482702 0.363289633327797 no 2163 0.360229931759187 3222 16648368
SGTC_2412 st077135 33.4 µM -0.358464825379153 0.363065112602107 no 2164 0.35999774327674 3274 13258915
SGTC_1832 st054113 55 µM -0.358642905763396 0.363000691393497 no 2165 0.359931122527871 3166 1251267
SGTC_1924 st058459 75.1 µM -0.35926799681065 0.362774593191676 no 2166 0.359697306579758 3032 688683
SGTC_720 r052-1644 49.9 µM -0.359919411365912 0.36253902455798 no 2167 0.359453700164046 3141 1422863 YOR257W CDC31
SGTC_1751 st044839 27.194 µM -0.360679866034608 0.36226408997732 no 2168 0.359169388787544 3071 5291326
SGTC_3025 9087895 49.47 µM -0.362929593894188 0.361451140368113 no 2169 0.358328739555341 3169 17173641
SGTC_1240 0356-0016 42.1 µM -0.363394089359841 0.361283370511074 no 2170 0.358155258223904 3075 4305613
SGTC_1365 1672-3266 55.4 µM -0.364139112906708 0.361014333192349 no 2171 0.35787706547882 3138 6415873
SGTC_530 4358-1714 28 µM -0.364489386072837 0.360887868922096 no 2172 0.357746299101624 3112 1564641
SGTC_937 3122-0005 46.7 µM -0.364730842424856 0.360800701239954 no 2173 0.357656166682125 3191 759535
SGTC_1882 5615643 20 µM -0.367617571387979 0.359759130038054 no 2174 0.35657920544536 3127 2253075
SGTC_634 1611-4317 11.2 µM -0.367761341321546 0.359707283027629 no 2175 0.35652559853222 3155 2843522
SGTC_2742 clothiapine 36.27 µM -0.371139791582812 0.358489674966845 no 2176 0.35526670737775 3114 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3036 9090181 49.47 µM -0.371152126729128 0.358485231952801 no 2177 0.355262113890813 3028 25236586
SGTC_143 4032-1194 15.74 µM -0.372675242286851 0.357936766161028 no 2178 0.354695082472192 2997 1806963
SGTC_965 1291-5240 308 µM -0.373058871109214 0.357798669634274 no 2179 0.354552314317707 3195 2834598
SGTC_2033 5192550 145 µM -0.37453038524709 0.357269135063764 no 2180 0.35400487733632 3085 182073
SGTC_3322 9139058 2.11 µM -0.37553652085995 0.356907228270023 no 2181 0.3536307453908 3233 4908926 YPR165W RHO1
SGTC_678 1218-2179 85.9 µM -0.376081797468188 0.356711146144908 no 2182 0.353428043091236 3132 6820081 YOR116C RPO31
SGTC_2163 5671233 125 µM -0.378222163355253 0.355941834385712 no 2183 0.352632781136203 3286 701023
SGTC_2184 6075246 200 µM -0.378771103192389 0.355744623254227 no 2184 0.352428923792312 3126 2267320
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.37997592814581 0.355311915429119 no 2185 0.351981641978765 3128 229346 A bile salt which induces apoptosis.
SGTC_2388 9080168 200 µM -0.380046797912784 0.355286468651274 no 2186 0.351955338503407 3050 15943073
SGTC_1933 st074711 15.9 µM -0.380479463884631 0.35513112790033 no 2187 0.351794768912235 3105 17250958
SGTC_1334 1486-0610 236 µM -0.38093282166724 0.354968383963311 no 2188 0.351626548600994 3153 3742339
SGTC_1624 st003710 6.25 µM -0.381259195697404 0.354851240347994 no 2189 0.351505464126956 3187 24207033
SGTC_1187 1391-0724 117 µM -0.381783570117101 0.354663058292001 no 2190 0.35131095323821 3122 6997986
SGTC_2717 st081029 62.2815 µM -0.383993699798329 0.35387030006888 no 2191 0.350491558526042 3183 5292846
SGTC_804 1595-0054 20.9 µM -0.385737463632161 0.353245270678051 no 2192 0.34984555705574 3081 761523 Stimulates phospholipase C.
SGTC_3169 9102970 49.47 µM -0.38709776701791 0.352757962279571 no 2193 0.349341915333809 3160 17027839
SGTC_1386 3228-0095 33.8 µM -0.387640802818807 0.352563495199577 no 2194 0.349140934565318 3203 870181
SGTC_288 1315-0019 35.1 µM -0.388061444340311 0.352412885331322 no 2195 0.348985281717721 3190 6811474
SGTC_2691 st077356 60.2 µM -0.390984260403662 0.351367016897609 no 2196 0.34790443503942 3247 2839272
SGTC_1272 0839-0021 27 µM -0.391573837806922 0.351156185016452 no 2197 0.347686560841601 3166 5027250
SGTC_2492 derrusnin 100 µM -0.394245414532092 0.350201408554535 no 2198 0.346699929615002 3016 1715307 Part of coumarin class of compounds.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.394856528951554 0.349983139298984 no 2199 0.346474386705576 3059 4000243
SGTC_1102 cgs 12066b 26.1 µM -0.39932512569564 0.348388618893342 no 2200 0.344826827974698 3146 6438352 A 5-HT1B full agonist.
SGTC_505 gw-5074 63.9 µM -0.399655658416263 0.348270781501882 no 2201 0.344705077844167 3204 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3259 9138485 49.47 µM -0.399690399181668 0.34825839700906 no 2202 0.344692282184886 3405 17646153
SGTC_568 1193-0097 7.48 µM -0.402246267041926 0.34734771811954 no 2203 0.343751397532181 3182 3646150
SGTC_1966 st070145 16.1 µM -0.404042656969376 0.346708174679571 no 2204 0.343090675675431 3051 3748532
SGTC_897 1000-0139 31.4 µM -0.404772895388311 0.34644832286951 no 2205 0.342822227009967 3257 6151020
SGTC_356 1634-0012 32.5 µM -0.40654005750823 0.345819785946113 no 2206 0.342172915240049 3238 735457
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.40712870003411 0.345610514206819 no 2207 0.341956732637815 3046 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1763 st044482 94.5 µM -0.407313869947977 0.34554469312085 no 2208 0.341888738551528 3221 88505
SGTC_2106 5357045 167.29 µM -0.408054735187685 0.345281389543544 no 2209 0.341616745383494 3203 668842
SGTC_277 nystatin 15.5 µM -0.408689530707902 0.345055842704634 no 2210 0.34138375888979 3073 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1300 1094-0077 113 µM -0.411180878136626 0.344171183798994 no 2211 0.340469954260716 3135 5532636
SGTC_847 0342-0274 5.54 µM -0.412502238367871 0.343702324115749 no 2212 0.339985670200877 3232 18097
SGTC_2172 5754775 163.918 µM -0.412972309157633 0.343535586302798 no 2213 0.339813450889551 3117 2263357
SGTC_729 4092-0585 94.1 µM -0.413216955347358 0.343448820413475 no 2214 0.339723833362044 3105 2169061
SGTC_340 k038-0059 454 µM -0.413516780299886 0.343342496148285 no 2215 0.3396140153903 3195 23733424
SGTC_2418 pentamidine 31.67 µM -0.414341015619 0.343050268790689 no 2216 0.339312189916909 3228 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_274 sirtinol 40.1 µM -0.41438865094228 0.343033382858687 no 2217 0.339294749559169 3165 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_135 0933-0004 26.348 µM -0.41481660131488 0.342881695611777 no 2218 0.339138082794956 3245 21230617 YGL099W LSG1
SGTC_2199 6590217 200 µM -0.415020936860031 0.342809277695033 no 2219 0.33906328816094 3153 703109
SGTC_2616 abietic acid 100 µM -0.415028482655901 0.342806603523856 no 2220 0.339060526232125 3288 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1167 k781-0610 148 µM -0.415505120213026 0.342637702858959 no 2221 0.338886083838521 3161 4525169
SGTC_1423 4048-0112 5.59 µM -0.416061544344766 0.342440568922942 no 2222 0.338682484426504 3222 X1423
SGTC_428 3448-4153 16.5 µM -0.416777475478755 0.342186986838419 no 2223 0.338420589645001 3051 3834874
SGTC_1369 1866-0067 208 µM -0.417023020046606 0.3421000315804 no 2224 0.338330784970702 3277 3531355
SGTC_3111 9122088 49.47 µM -0.418309666477309 0.341644525524852 no 2225 0.337860361510161 3143 16876704
SGTC_1500 4488-1866 171 µM -0.419087338832256 0.341369321150102 no 2226 0.337576151759046 3275 2900003
SGTC_362 0310-0100 9.03 µM -0.421109101416031 0.340654250355532 no 2227 0.336837707924673 3261 790235
SGTC_3245 9134821 49.47 µM -0.421392279286353 0.340554139708398 no 2228 0.336734328018804 3152 17014901
SGTC_3180 9109287 49.47 µM -0.42183532061046 0.340397535761983 no 2229 0.336572611420509 3244 18891271
SGTC_3269 9137823 49.47 µM -0.422186838792867 0.340273302517061 no 2230 0.336444323614433 3121 17682936
SGTC_1458 k015-0034 6.33 µM -0.423068763976538 0.339961689627848 no 2231 0.336122545720367 3195 3598957
SGTC_1085 doxorubicin 7.67 µM -0.423429223782057 0.339834358894989 no 2232 0.335991063444143 3265 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_284 0988-0104 32.6 µM -0.425094939191896 0.339246190259941 no 2233 0.335383733504785 3214 4666532
SGTC_1318 1280-3875 124 µM -0.426352695016109 0.338802332568938 no 2234 0.334925432882822 3204 373245
SGTC_796 1234-0020 70.7 µM -0.427853956333551 0.338272835557069 no 2235 0.334378725518308 3169 46495034
SGTC_1449 4112-4002 201 µM -0.429198043532748 0.337799045255957 no 2236 0.333889553336092 3203 2059539
SGTC_950 1165-0508 94.1 µM -0.429508332083158 0.337689705114506 no 2237 0.333776665801286 3214 6148369
SGTC_2516 gossypol 71.55 µM -0.430436164876366 0.337362835167477 no 2238 0.33343919637847 3296 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2367 9070478 135.38 µM -0.431265542119824 0.337070754373018 no 2239 0.333137651057084 3168 572802
SGTC_2622 2-methoxyxanthone 59.94 µM -0.434517942787226 0.335926309288848 no 2240 0.331956184078126 3165 71034 A hepatoprotective.
SGTC_1035 k081-0041 55.2 µM -0.43528481551257 0.335656685392478 no 2241 0.331677852622069 3317 731709
SGTC_981 1488-1094 54.9 µM -0.435828609880429 0.335465544607022 no 2242 0.331480542284475 3150 3449522
SGTC_2865 9030313 51.95 µM -0.436738731872248 0.335145736916893 no 2243 0.33115041827651 3111 42562754
SGTC_2049 5262831 67.185 µM -0.436762674751614 0.335137325242303 no 2244 0.331141735365472 3232 763417
SGTC_26 0302-0163 425.158 µM -0.437330489096209 0.334937863469847 no 2245 0.330935843500072 3218 3100915
SGTC_3166 9102297 49.47 µM -0.439565116594044 0.334153336257212 no 2246 0.330126055175083 3225 25237072
SGTC_2164 5685496 200 µM -0.44020157951877 0.333930020835441 no 2247 0.329895557922987 3307 759046
SGTC_2614 arthonioic acid 13.39 µM -0.440816912646116 0.333714175113434 no 2248 0.329672774289336 3225 6710684
SGTC_1873 rapamycin 2 nM -0.441635354577028 0.333427168425754 no 2249 0.329376548003219 3191 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_168 3970-0862 530.542 µM -0.442249115992091 0.333212001920398 no 2250 0.329154473869385 3264 3135186
SGTC_1587 estradiol valerate 56.1 µM -0.44286951787028 0.332994563240431 no 2251 0.328930058303467 3318 13791 A steroid.
SGTC_1994 st072947 40.9 µM -0.44434128447388 0.332478962601903 no 2252 0.32839792860821 3289 5286565 YDL195W SEC31
SGTC_2137 5261020 140 µM -0.444480662138245 0.332430151148982 no 2253 0.328347553449637 3172 763655
SGTC_711 k292-0785 179 µM -0.446025942276006 0.331889169140078 no 2254 0.327789253351946 3178 4146315
SGTC_671 0560-0003 407 µM -0.448249758311472 0.331111255734825 no 2255 0.326986477844587 3184 3238678
SGTC_547 1120-0019 610 nM -0.449154303890843 0.330795044722191 no 2256 0.32666017452448 3206 3676939
SGTC_2957 9076800 11.52 µM -0.449614434592778 0.330634238547472 no 2257 0.32649423906941 3198 16459615
SGTC_2669 eugenol 100 µM -0.45009337348319 0.330466892498491 no 2258 0.326321557336931 3247 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2989 9073649 71.4286 µM -0.450798367209546 0.330220622295234 no 2259 0.32606743911149 3316 21367202
SGTC_2739 tacrine 100.86 µM -0.451068873656638 0.330126147808608 no 2260 0.325969955250955 3285 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_722 3534-0461 190 µM -0.451993751631723 0.329803215650625 no 2261 0.32563674189771 3238 658262
SGTC_715 0868-0130 184 µM -0.452371562417492 0.329671334987064 no 2262 0.325500664967659 3335 2876258
SGTC_462 ag-879 158 µM -0.453211525776291 0.329378208756376 no 2263 0.325198216888791 3273 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_35 0133-0054 64.071 µM -0.453473614816206 0.329286767677273 no 2264 0.325103869271786 3223 99677
SGTC_2644 guaiazulene 100 µM -0.455167058486704 0.328696183048904 no 2265 0.324494528727559 3285 3515 A coloring agent.
SGTC_280 3448-3607 3.04 µM -0.455173869701973 0.328693808515462 no 2266 0.324492078840442 3300 626179
SGTC_3090 9117696 49.47 µM -0.457113422725378 0.328017921099273 no 2267 0.323794761463055 3233 7923821
SGTC_646 4092-0839 27.3 µM -0.457244090169326 0.327972406860046 no 2268 0.323747805474079 3348 877796
SGTC_2250 alverine citrate 130 µM -0.45964388306538 0.32713696303717 no 2269 0.322885927626793 3247 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_946 3434-1334 87.4 µM -0.463922102752165 0.325649727948919 no 2270 0.321351778269893 3297 4047976
SGTC_1310 1188-0297 994 nM -0.465432880946457 0.325125197767159 no 2271 0.320810745979247 3228 1588352
SGTC_1636 st007707 68.9 µM -0.465484837025374 0.325107165184304 no 2272 0.320792146488197 3404 403051
SGTC_2481 5478948 45.16 µM -0.465806099204202 0.324995672665074 no 2273 0.320677149474672 3344 77792
SGTC_2805 7950783 58.44 µM -0.465886134202929 0.324967899335295 no 2274 0.320648503320839 3291 1178958 YDL195W SEC31
SGTC_2440 5628896 157.78 µM -0.468477656568164 0.324069129095403 no 2275 0.319721522798198 3209 5522048
SGTC_372 0155-0182 15.9 µM -0.469395625262145 0.323751012261851 no 2276 0.319393437398171 3221 771486
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.470862793140444 0.323242840912817 no 2277 0.318869359744002 3246 91467 include heat shock
SGTC_2166 5933061 31.504 µM -0.471452998858868 0.323038508939187 no 2278 0.318658638166241 3617 2877375
SGTC_3332 9141069 11.198 µM -0.47182582065884 0.322909463803818 no 2279 0.318525559536673 3190 17332883
SGTC_341 1486-1430 230 µM -0.472156925201093 0.322794876171385 no 2280 0.318407391494419 3182 2054753 YPL210C SRP72
SGTC_195 4234-0266 16.654 µM -0.472926467802082 0.322528620256636 no 2281 0.318132820479531 3239 2303354
SGTC_809 3998-0021 90 µM -0.47604312555185 0.321451211923544 no 2282 0.31702182722886 3338 715485
SGTC_2032 5185112 25.99 µM -0.476472742632255 0.321302813558647 no 2283 0.316868810852267 3246 5718189
SGTC_1434 4073-0095 163 µM -0.476487047618294 0.321297872819844 no 2284 0.316863716395337 3331 24133745
SGTC_2844 9010103 25.97 µM -0.477472309663051 0.320957653456653 no 2285 0.316512917093705 3368 2480525
SGTC_395 anisomycin 6.25 µM -0.477605925043213 0.320911526494736 no 2286 0.31646535647706 3281 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1653 st012112 65 µM -0.478314699621606 0.320666888187943 no 2287 0.316213117753826 3365 720429
SGTC_1755 st041960 45.185 µM -0.479682216832486 0.320195100568613 no 2288 0.315726687384748 3352 2257073
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.479743522247911 0.320173957260049 no 2289 0.315704888312094 3549 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_686 1319-0111 510 µM -0.480878497127118 0.319782627158385 no 2290 0.315301428094589 3393 4562600
SGTC_324 1315-0088 19.6 µM -0.481741425579646 0.319485230600647 no 2291 0.314994822079287 3312 6787421
SGTC_857 0438-0306 1.35 µM -0.484401585453424 0.318569173732391 no 2292 0.314050446729023 3358 4686136
SGTC_3 0833-0587 95.581 µM -0.484533289980335 0.318523848491257 no 2293 0.314003722254917 3298 5382644
SGTC_2584 androsterone 48.74 µM -0.484818095514607 0.318425843838335 no 2294 0.313902692728778 3347 2754130 A steroid.
SGTC_1986 st071812 45 µM -0.48565848271446 0.318136731623244 no 2295 0.313604662153299 3335 11838594
SGTC_785 1270-0111 65.3 µM -0.486818787702425 0.317737742520502 no 2296 0.31319337748885 3258 6741994
SGTC_3098 9119039 49.47 µM -0.489335570502943 0.316873034770238 no 2297 0.312302071047726 3354 17161528
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.490102902792601 0.316609595908137 no 2298 0.312030542054354 3275 88881 An O-methylated flavonoid and antioxidant.
SGTC_2914 7968218 45.32 µM -0.49176998758274 0.316037576594238 no 2299 0.311440977731862 3308 2977111
SGTC_2942 9052777 62.25 µM -0.492165094382817 0.315902069839542 no 2300 0.311301319038787 3321 6469503
SGTC_2229 7354935 190 µM -0.493275059155788 0.315521526112276 no 2301 0.310909124319773 3315 318112
SGTC_3185 9108267 49.47 µM -0.493979845600761 0.315279996443797 no 2302 0.31066020663408 3347 4910486
SGTC_925 2064-1272 59.6 µM -0.494433577372916 0.315124544736302 no 2303 0.310500002708804 3268 6815817
SGTC_1247 0448-0043 5.84 µM -0.494480566206178 0.315108447900481 no 2304 0.310483413912399 3344 3089013 YGL099W LSG1
SGTC_1429 4049-0205 9.46 µM -0.495386259654332 0.314798255608601 no 2305 0.310163745965625 3355 22774478
SGTC_534 k292-0788 63.4 µM -0.496547840299092 0.314400615338329 no 2306 0.309753971572149 3422 4146317
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.496927786058745 0.314270596389505 no 2307 0.309619988195215 3376 756377
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.497035025313441 0.314233902859193 no 2308 0.309582176117377 3264 15053
SGTC_1022 4477-0945 21.3 µM -0.497415590195518 0.314103701657613 no 2309 0.309448006924136 3303 4648966
SGTC_2716 st080858 38.6235 µM -0.497572316012421 0.314050088380076 no 2310 0.309392760189402 3381 5296050
SGTC_2797 7859098 81.82 µM -0.497943292109393 0.313923199309278 no 2311 0.309262006191572 3259 972681
SGTC_1378 2093-0007 380 nM -0.497952954223092 0.313919894763219 no 2312 0.309258601011803 3356 3618014
SGTC_2833 9001315 45.46 µM -0.498426052344844 0.313758108413221 no 2313 0.309091888993637 3212 2989378
SGTC_533 1222-0222 6.71 µM -0.49937791446359 0.313432706658879 no 2314 0.308756587524518 3418 3982874
SGTC_3335 9143315 29.6265 µM -0.500289381738949 0.313121250247189 no 2315 0.308435664821216 3273 4899691
SGTC_994 3910-0338 138 µM -0.501622948399747 0.312665798949102 no 2316 0.307966386886924 3436 3479481
SGTC_2541 muurolladie-3-one 83.07 µM -0.503297745138147 0.312094212806904 no 2317 0.307377475770667 3429 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_704 1310-0270 142 µM -0.504176564438009 0.311794464069479 no 2318 0.307068653732075 3330 5718033
SGTC_976 1348-1067 47.6 µM -0.507140295980503 0.310784510747893 no 2319 0.306028191466019 3326 5310671 YGL099W LSG1
SGTC_1822 st052468 42 µM -0.507794532169514 0.310561757721894 no 2320 0.305798722385064 3321 2873678
SGTC_1271 0832-2808 169 µM -0.507794706161305 0.310561698490751 no 2321 0.305798661368712 3408 3663794
SGTC_2714 st079313 56.9 µM -0.508139962573281 0.31044417427674 no 2322 0.305677595662977 3312 2939799
SGTC_766 1391-0721 126 µM -0.508596592232094 0.310288768672649 no 2323 0.305517509050717 3398 1020919 YIL115C NUP159
SGTC_2108 5365811 200 µM -0.509309459127539 0.310046225096845 no 2324 0.305267664336807 3372 780283
SGTC_478 N-arachidonylglycine 10 µM -0.510015050079431 0.309806238430418 no 2325 0.305020458997155 3331 5283389
SGTC_575 k072-0246 11.9 µM -0.510494442045144 0.309643233131662 no 2326 0.304852553707298 3349 6796779
SGTC_2976 9009005 19.48 µM -0.513132311047921 0.308746961832257 no 2327 0.303929385497035 3423 2993148
SGTC_456 gingerol 170 µM -0.51315392013581 0.308739624383779 no 2328 0.303921828170459 3457 442793 A herb.
SGTC_2764 methyldopa 94.69 µM -0.513557956497722 0.308602446353334 no 2329 0.303780540337132 3463 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1732 st034308 51.822 µM -0.51359228977818 0.308590790782476 no 2330 0.303768535652943 3244 830119
SGTC_1701 st028638 40.4 µM -0.514635105824512 0.308236864220282 no 2331 0.303404014327408 3412 3490878
SGTC_835 0312-0010 67.2 µM -0.517012819597415 0.307430546787639 no 2332 0.30257360493834 3316 1626196
SGTC_1278 0874-0585 172 µM -0.517518095196195 0.307259320106989 no 2333 0.302397270271978 3346 766306
SGTC_2694 st077685 81.9 µM -0.518931154780609 0.306780688694471 no 2334 0.301904375564818 3256 2838096
SGTC_2552 juarezic acid 87.02 µM -0.520632156014269 0.30620496242894 no 2335 0.301311522128701 3394 1549512
SGTC_2666 tannic acid 100 µM -0.521178268686308 0.306020224754823 no 2336 0.301121295593759 3425 16134267 A thiamine antagonist.
SGTC_2978 9011784 42.97 µM -0.521791702449856 0.305812772689526 no 2337 0.300907683771387 3361 2994934
SGTC_1468 k284-1086 134 µM -0.524929264024322 0.304752682080662 no 2338 0.29981618256654 3371 15996457
SGTC_1321 1326-2144 215 µM -0.525340457238215 0.304613873035176 no 2339 0.299673268807943 3388 3513030
SGTC_81 0411-0046 9.971 µM -0.528581801953617 0.303520658270535 no 2340 0.298547793532098 3343 12925265
SGTC_3151 9099821 49.47 µM -0.529811378436409 0.303106415480799 no 2341 0.298121357670693 3390 17174189
SGTC_2263 7948595 193.29 µM -0.530260627066362 0.302955127278389 no 2342 0.297965620644595 3372 2971371
SGTC_1002 4049-0206 172 µM -0.532022171105088 0.302362239061458 no 2343 0.297355319949048 3354 4662749
SGTC_1674 st016616 23.6 µM -0.532307914026793 0.302266114778415 no 2344 0.297256375934602 3298 625830
SGTC_2378 9074213 121.43 µM -0.533371480616721 0.301908450188265 no 2345 0.296888227722212 3410 657714
SGTC_1809 st050081 57.6 µM -0.533423492372204 0.301890964141333 no 2346 0.296870229467596 3488 5036894
SGTC_2084 5306078 60.6385 µM -0.533467225878444 0.301876261545406 no 2347 0.296855096221789 3314 679340
SGTC_2114 5491910 81.25 µM -0.534180117132689 0.301636642816206 no 2348 0.296608461967907 3437 2849228
SGTC_2068 5226020 147 µM -0.535120603001447 0.301320655374861 no 2349 0.2962832319888 3370 1810509
SGTC_3021 9087658 49.47 µM -0.535578955612459 0.301166710644247 no 2350 0.296124788094989 3428 25237042
SGTC_2455 5377712 9.75 µM -0.536030992508465 0.30101492185838 no 2351 0.295968565515735 3384 2243908
SGTC_1683 st010134 710 nM -0.536152720156529 0.300974053009943 no 2352 0.295926503277529 3342 3818134
SGTC_276 colchicine 750 µM -0.536183328456046 0.300963776971106 no 2353 0.295915927200252 3468 2833 A microtubule depolymerizer.
SGTC_1884 5633444 25 µM -0.536405648814064 0.300889142726532 no 2354 0.295839114117663 3447 5724239
SGTC_901 1112-0062 60.1 µM -0.537402443227549 0.300554615672515 no 2355 0.295494828015659 3378 1908457
SGTC_2178 5812956 200 µM -0.54008770193899 0.299654271911313 no 2356 0.294568275724498 3403 5403383
SGTC_95 0471-0001 561.058 µM -0.540214091147793 0.29961192483947 no 2357 0.294524698001669 3382 4015405
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.542097461538275 0.298981217652672 no 2358 0.293875683678027 3465 551469
SGTC_2991 9074669 71.4286 µM -0.542667102843879 0.298790573764867 no 2359 0.293679514181924 3464 17333109
SGTC_1201 1889-3372 45.9 µM -0.543093613967088 0.298647867944477 no 2360 0.293532674650658 3324 5392199
SGTC_926 2268-1401 59.4 µM -0.543695442523933 0.298446555620842 no 2361 0.293325534573646 3433 2931578
SGTC_1038 k292-0204 154 µM -0.54432636914244 0.298235576287411 no 2362 0.293108452156468 3387 4454212
SGTC_3308 9128332 17.569 µM -0.544936307516003 0.298031679930796 no 2363 0.292898662008926 3464 17332805 YDL196W YDL196W
SGTC_2886 9058944 51.95 µM -0.547428850724729 0.297199108462156 no 2364 0.292042069416525 3288 4949929
SGTC_3092 9117248 49.47 µM -0.548667330691539 0.296785821067539 no 2365 0.291616884938515 3439 17141857
SGTC_353 1988-1175 58.3 µM -0.54967091339915 0.296451113245183 no 2366 0.291272555227992 3308 2788357
SGTC_3331 9141060 1.957 µM -0.551272637355875 0.295917276285165 no 2367 0.290723396453913 3349 4906567 YPR165W RHO1
SGTC_1743 st037606 46.3785 µM -0.552056984869176 0.295656023003682 no 2368 0.29045465585556 3382 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3270 9137563 49.47 µM -0.552485565935107 0.295513314490003 no 2369 0.290307860484092 3405 17015724
SGTC_265 mycophenolic acid 32.932 µM -0.553922765528559 0.295034988518658 no 2370 0.289815852101103 3554 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2922 7999257 32.47 µM -0.556165499638375 0.294289279485891 no 2371 0.289048860913009 3463 2988377
SGTC_1281 0884-0031 11.8 µM -0.556233015241361 0.294266844053171 no 2372 0.289025786106704 3419 1548255
SGTC_1397 3532-0190 20.1 µM -0.557198724304458 0.293946025463644 no 2373 0.288695830614887 3356 5322280
SGTC_957 1187-1561 14.1 µM -0.557848337482438 0.293730308246792 no 2374 0.288473975998575 3447 1538454
SGTC_1291 0993-0025 5.79 µM -0.558964282860376 0.293359907098671 no 2375 0.288093048210439 3501 4353356
SGTC_1628 st004252 77.7 µM -0.5597425010361 0.293101731485478 no 2376 0.287827544117295 3463 692968
SGTC_2245 6637752 200 µM -0.560055604130658 0.292997888572605 no 2377 0.287720755589689 3416 681890
SGTC_2847 9005661 71.43 µM -0.560267448037967 0.292927638686848 no 2378 0.287648513653201 3390 2991449
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.560548764725625 0.292834362908901 no 2379 0.287552593713818 3402 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1690 st023502 41.2 µM -0.561085222283667 0.292656528659674 no 2380 0.287369720871892 3469 24207482
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.563373676587867 0.291898476210471 no 2381 0.286590229021931 3440 521171
SGTC_2289 7946404 165.07 µM -0.566339307028515 0.290917471337995 no 2382 0.285581572341237 3434 1246120 YPR165W RHO1
SGTC_1935 st074532 41.6 µM -0.567619771590462 0.290494381530174 no 2383 0.28514658942751 3491 2829742
SGTC_1241 0364-0022 50.8 µM -0.569340186662339 0.289926377553338 no 2384 0.284562649857453 3405 4563895
SGTC_909 3448-9333 149 µM -0.571876973932057 0.289089795520413 no 2385 0.283702662305237 3420 3344074
SGTC_3294 9122953 26.2835 µM -0.573739240351877 0.288476380583199 no 2386 0.283072135079212 3489 16459826
SGTC_285 1486-1325 46 µM -0.574167594310124 0.28833537120719 no 2387 0.282927197949807 3504 22310230
SGTC_2753 fluvastatin 17.09 µM -0.574334410470965 0.28828046596978 no 2388 0.282870763954425 3430 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2443 5493264 126.67 µM -0.574878522634318 0.288101413237969 no 2389 0.282686728105257 3496 5340055
SGTC_667 1498-1044 59 µM -0.574951241301693 0.28807748744932 no 2390 0.282662136723901 3430 6739982
SGTC_1427 4048-4900 550 nM -0.576234645111855 0.287655378215025 no 2391 0.282228295398799 3488 24132586
SGTC_3210 9128157 49.47 µM -0.576639657271672 0.287522231138727 no 2392 0.282091451800082 3379 17590849
SGTC_2193 5925765 200 µM -0.57772189752056 0.287166589488362 no 2393 0.281725946388299 3482 877370
SGTC_2254 7938975 95.19 µM -0.577910966529834 0.287104479728525 no 2394 0.281662115473684 3559 2969277
SGTC_2159 5658611 73.75 µM -0.578034304783985 0.287063966155308 no 2395 0.281620479443721 3511 793844
SGTC_2448 5185112 27.17 µM -0.578752553543264 0.286828092964091 no 2396 0.281378074913397 3475 5718189
SGTC_1411 3909-8223 150 µM -0.57937074139409 0.286625153396374 no 2397 0.281169520989118 3511 X1411
SGTC_3336 9143619 71.43 µM -0.580002630634637 0.286417786321718 no 2398 0.280956421902002 3519 45595730
SGTC_972 1319-0219 195 µM -0.581057442741601 0.286071787378995 no 2399 0.280600869797009 3452 23903702
SGTC_1033 k072-0102 21.3 µM -0.581328769341779 0.28598281908602 no 2400 0.280509447260932 3502 5965931
SGTC_539 4859-0462 2.54 µM -0.58133085001375 0.285982136882188 no 2401 0.280508746241592 3502 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1433 4060-0023 7.6 µM -0.581885423859381 0.285800332630515 no 2402 0.280321929635616 3490 3840627
SGTC_2222 6885208 172.143 µM -0.582010224962256 0.285759427043613 no 2403 0.280279896799536 3467 609514
SGTC_518 1021-0119 62.6 µM -0.582083726534967 0.285735337013353 no 2404 0.280255143001604 3399 1097762
SGTC_627 1391-0720 175 µM -0.583442240892292 0.285290259996842 no 2405 0.279797814449151 3429 997839
SGTC_1472 k841-0093 193 µM -0.584595225706911 0.284912777946254 no 2406 0.279409959340047 3551 X1472
SGTC_625 k213-0058 121 µM -0.584660452320525 0.284891430168081 no 2407 0.279388025422581 3530 3655420
SGTC_2729 fluphenazine 10.66 µM -0.585235133598208 0.284703377833467 no 2408 0.279194812059797 3421 3372 An atypical antipsychotic.
SGTC_198 3454-2873 16.191 µM -0.586732500696919 0.284213674527677 no 2409 0.278691688157827 3437 710957
SGTC_1232 0279-0259 161 µM -0.588323839059368 0.283693680425519 no 2410 0.278157473680614 3476 1560000
SGTC_1332 1480-0653 17.5 µM -0.589078860848657 0.28344712501289 no 2411 0.277904186633192 3485 5749438
SGTC_2504 purpurogallin 52.29 µM -0.590014317334453 0.283141790459985 no 2412 0.277590525414245 3393 5281571 An antioxidant.
SGTC_605 1315-0399 119 µM -0.590852459241151 0.282868353664691 no 2413 0.27730964104688 3572 24020461
SGTC_1298 1079-1278 263 µM -0.591020255993134 0.282813626616057 no 2414 0.277253424450979 3505 2840950
SGTC_1975 st070967 30.8 µM -0.593528210495294 0.281996261880384 no 2415 0.276413854604229 3533 261391
SGTC_747 3448-8087 38.7 µM -0.593626143466139 0.28196436774776 no 2416 0.276381095601798 3463 5168703
SGTC_2331 7980721 200 µM -0.593952646049214 0.281858047199792 no 2417 0.276271892834849 3445 2981221
SGTC_1742 st038235 28.8875 µM -0.59410842542601 0.281807326848132 no 2418 0.276219797985532 3471 564103 YBR002C RER2
SGTC_278 4092-0821 23.9 µM -0.594422164123666 0.281705189727394 no 2419 0.276114893915874 3498 877900
SGTC_1680 diphenhydramine 100 µM -0.594775478733361 0.281590190102874 no 2420 0.275996780361159 3430 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1898 st060199 18.6 µM -0.595557893816134 0.281335604089848 no 2421 0.275735306282186 3513 688866
SGTC_840 0245-0196 390 µM -0.598056054700275 0.280523484887457 no 2422 0.274901265658265 3569 3827528
SGTC_2663 amphotericin b 100 µM -0.598799117187079 0.280282144172998 no 2423 0.27465342555184 3498 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_512 prima-1 270 µM -0.599182310039494 0.280157725534738 no 2424 0.274525658982887 3540 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1801 st050089 28.441 µM -0.599815001324739 0.279952356002869 no 2425 0.274314767281283 3515 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_305 1682-2595 20.8 µM -0.600181781266704 0.279833333861288 no 2426 0.274192547063242 3503 226033
SGTC_3157 9099274 49.47 µM -0.600450785492019 0.279746056091889 no 2427 0.274102925250889 3520 17217662
SGTC_784 4579-0127 173 µM -0.604291938567188 0.278501246173581 no 2428 0.272824782500847 3566 1948547
SGTC_2189 6047310 154.431 µM -0.604995068546435 0.278273674008357 no 2429 0.27259113669054 3497 711535
SGTC_2561 acetosyringone 100 µM -0.606869214594898 0.277667538818251 no 2430 0.271968854988164 3458 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1527 coumarin 137 µM -0.608947168674416 0.276996242991723 no 2431 0.271279728909858 3559 323 A hepatotoxic, DNA x-linker.
SGTC_2235 salicylic acid 500 µM -0.609419841044817 0.27684365426775 no 2432 0.271123094940954 3531 338 A COX inhibitor and kinase inhibitor.
SGTC_3330 9141424 71.43 µM -0.609908000816769 0.276686109106144 no 2433 0.270961376118053 3538 27261020
SGTC_2400 5203494 178.7 µM -0.610510276293143 0.276491795623363 no 2434 0.270761919092271 3528 6777674
SGTC_446 go6976 132 µM -0.61207734180818 0.275986523532099 no 2435 0.270243293929287 3513 3501 A protein kinase C inhibitor.
SGTC_2203 7227154 166.4 µM -0.612090028396954 0.275982434820885 no 2436 0.270239097291485 3546 896304
SGTC_144 4161-2749 112.381 µM -0.613232458624727 0.275614367444192 no 2437 0.269861322743304 3477 797501 YMR168C CEP3
SGTC_2897 9048598 12.99 µM -0.613390499350709 0.275563469003401 no 2438 0.269809083252368 3471 6467404
SGTC_108 0509-0257 621.132 µM -0.614158330534318 0.275316247851444 no 2439 0.269555352967753 3512 536624
SGTC_1568 digitonin 820 nM -0.614367651220188 0.275248871116232 no 2440 0.269486203565571 3575 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_564 3555-0129 330 µM -0.615405647246437 0.274914877988059 no 2441 0.269143431436857 3478 563260
SGTC_528 3492-0019 172 µM -0.615730868737913 0.27481027346728 no 2442 0.26903608022787 3563 2869262
SGTC_3161 9100388 49.47 µM -0.615901138939265 0.274755515439182 no 2443 0.268979884913134 3563 25236368
SGTC_716 1683-5115 658 µM -0.616079274646391 0.274698233663105 no 2444 0.268921100004979 3586 723597
SGTC_2138 5575593 77.673 µM -0.617016992407081 0.274396795857399 no 2445 0.268611758873739 3526 762213
SGTC_1317 1273-0028 910 nM -0.618420842609806 0.273945820989365 no 2446 0.268148981098783 3514 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2670 beta-carotene 100 µM -0.619018070773169 0.273754077695168 no 2447 0.267952227181285 3509 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1312 1218-2183 165 µM -0.619939096696581 0.273458507575605 no 2448 0.267648942238133 3570 6744073
SGTC_655 k060-0012 42 µM -0.620763420161944 0.27319410467165 no 2449 0.267377647285425 3483 5994525
SGTC_2928 9011484 9.79 µM -0.621751533493197 0.272877332946144 no 2450 0.267052629984518 3535 2994751
SGTC_1199 1638-0010 4.46 µM -0.621985600928324 0.272802321745976 no 2451 0.266975668086681 3496 3111136
SGTC_112 phenothiazine 287.218 µM -0.622426014478172 0.272661210886667 no 2452 0.266830889498146 3557 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2491 paeonol 100 µM -0.623656672540011 0.272267093596236 no 2453 0.266426541663147 3520 11092 Increases levels of cortical cytochrome oxidase.
SGTC_791 1348-1292 225 µM -0.623944304505203 0.272175020511119 no 2454 0.266332081357118 3563 5437054
SGTC_1916 st067606 49.2 µM -0.624221224571811 0.272086391007652 no 2455 0.266241154927601 3531 19590279
SGTC_764 1951-2361 146 µM -0.624930149980633 0.271859561674004 no 2456 0.266008451599044 3482 5438930
SGTC_1032 k061-1018 98.7 µM -0.624958372621627 0.271850533443391 no 2457 0.265999189707206 3636 4005393
SGTC_1709 st033179 39.1045 µM -0.626033950949925 0.271506574477938 no 2458 0.265646336372224 3544 573381
SGTC_1303 1160-0052 261 µM -0.626434712551128 0.271378470463157 no 2459 0.265514923576217 3567 3562476
SGTC_832 4083-0019 164 µM -0.627132639877853 0.27115544892223 no 2460 0.265286146618081 3637 1990758
SGTC_1498 4478-3555 97.6 µM -0.627178527330648 0.271140788863892 no 2461 0.265271108455777 3554 3437919
SGTC_3343 9148379 18.9835 µM -0.62732158905102 0.271095086245398 no 2462 0.265224227276664 3598 1955036
SGTC_2768 sulfasalazine 50.2 µM -0.627508037243926 0.271035529114436 no 2463 0.265163134709618 3609 5384001 An antioxidant and salicylic acid derivative.
SGTC_1077 5-fluorocytosine 377 nM -0.627666600224387 0.270984884490495 no 2464 0.265111184777425 3541 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_114 0364-0001 490.298 µM -0.627848827424564 0.270926687404472 no 2465 0.265051488130496 3547 4003655
SGTC_733 4069-0007 56.1 µM -0.629833546200141 0.270293240790144 no 2466 0.264401747497716 3605 5717425 YNL287W SEC21
SGTC_569 4130-2812 160 µM -0.630003607454514 0.270238998178636 no 2467 0.264346111999684 3491 743552
SGTC_2262 9014885 67.46 µM -0.630298723275109 0.27014488117618 no 2468 0.264249579077714 3511 6457424
SGTC_2880 9042983 58.44 µM -0.632084568173964 0.269575697628337 no 2469 0.263665809203039 3580 6464714
SGTC_1518 st038567 90.8 µM -0.634370335085377 0.268848057035033 no 2470 0.262919582303165 3580 77966
SGTC_2934 9036370 36.88 µM -0.636611217933202 0.268135663369386 no 2471 0.262189058164817 3561 6462800
SGTC_2912 7964298 10.93 µM -0.63760743701999 0.267819263104465 no 2472 0.26186462664054 3584 2975850
SGTC_3212 9128307 49.47 µM -0.63835367299226 0.267582381022288 no 2473 0.261621740269363 3456 27243542
SGTC_1874 staurosporine 7.6 µM -0.638965477040444 0.26738825128672 no 2474 0.261422695358952 3582 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_637 1181-0519 7.26 µM -0.639386030718008 0.267254847856609 no 2475 0.26128591714151 3591 6252091 YGR060W ERG25
SGTC_2050 5263056 171 µM -0.639866833871684 0.267102373908107 no 2476 0.261129588820564 3574 763468 YGL055W OLE1
SGTC_155 k072-0202 43.6 µM -0.640112725239521 0.267024412969756 no 2477 0.261049658293108 3542 5857737
SGTC_2950 9072895 21.46 µM -0.642417095610644 0.266294361111601 no 2478 0.260301201293014 3557 17332245
SGTC_2408 sulbentine 18.36 µM -0.643280678250915 0.266021028350711 no 2479 0.260020995670521 3514 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2785 7756463 72.73 µM -0.643422423826916 0.265976178003297 no 2480 0.259975018517969 3564 2201551
SGTC_377 3970-0964 33.1 µM -0.643640436444204 0.265907203140243 no 2481 0.259904311272224 3581 16481235
SGTC_2933 9026794 32.47 µM -0.644595089300828 0.265605276709142 no 2482 0.259594809019146 3567 17586027
SGTC_2421 5690543 90.72 µM -0.644748427038017 0.265556797055863 no 2483 0.259545114057654 3601 3397993
SGTC_3034 9090421 49.47 µM -0.6479731370081 0.264538305284364 no 2484 0.258501162488475 3533 17173761
SGTC_843 0310-0051 143 µM -0.648808197168775 0.264274884390318 no 2485 0.258231179218955 3574 2065037
SGTC_292 k038-0015 474 µM -0.649288211080443 0.264123523809869 no 2486 0.25807605212193 3585 46368540
SGTC_1895 st058434 18.3 µM -0.649488331997769 0.264060433647104 no 2487 0.258011392904284 3622 5393175
SGTC_1945 st075991 56.6 µM -0.649545059407366 0.264042551148849 no 2488 0.257993065764564 3524 1084980
SGTC_211 3455-0679 143.504 µM -0.649610874230801 0.264021804747662 no 2489 0.257971803565753 3613 748649
SGTC_2124 5246320 200 µM -0.650225927789298 0.263827965366773 no 2490 0.257773147732818 3595 579342
SGTC_1978 st071761 42 µM -0.652095461855873 0.263239211566858 no 2491 0.257169795732893 3531 5147680
SGTC_1226 3909-7979 35.4 µM -0.652153515123335 0.26322094017644 no 2492 0.257151072048153 3609 6615510
SGTC_2027 5150920 200 µM -0.652630886678563 0.263070719247725 no 2493 0.256997134221342 3594 786715
SGTC_3012 9080433 71.4286 µM -0.65304386874393 0.262940795980859 no 2494 0.256863998734387 3617 17688859
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.65359086877754 0.262768761462448 no 2495 0.25668771434648 3585 688664
SGTC_1641 st009299 47.1 µM -0.654799714873133 0.262388777027263 no 2496 0.256298357122569 3563 4046054
SGTC_1263 0774-1208 64.8 µM -0.655919382473914 0.262037075820787 no 2497 0.255937998213948 3645 906585
SGTC_2022 5136654 200 µM -0.659196412975228 0.261009111110253 no 2498 0.254884825020592 3601 1713771
SGTC_1603 st002045 67.8 µM -0.659866083933875 0.260799298894691 no 2499 0.254669885388517 3617 5887985
SGTC_1126 isoteolin 1.0172 µM -0.66047259573687 0.260609349757006 no 2500 0.254475299457824 3596 133323
SGTC_2320 7373003 200 µM -0.661864246209781 0.260173777925793 no 2501 0.254029113730976 3612 5415828
SGTC_1217 1183-1422 255 µM -0.662208871505147 0.260065971859522 no 2502 0.253918684708086 3634 2849664
SGTC_1105 epirubicin 18.1 µM -0.663864345292515 0.259548425954314 no 2503 0.253388569077343 3581 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_877 0771-0151 33.1 µM -0.665337457636266 0.259088338756744 no 2504 0.252917338784294 3616 6166523
SGTC_2626 ethyl orsellinate 100 µM -0.665843726683293 0.258930316598476 no 2505 0.252755496180062 3613 75653 A natural product.
SGTC_1146 3579-1023 7 µM -0.669916340178206 0.257660944638303 no 2506 0.251455561334825 3653 X1146
SGTC_1959 st077091 55.8 µM -0.671062125545966 0.257304403950615 no 2507 0.251090476729344 3638 821356 YKL052C ASK1
SGTC_2525 harmine 47.85 µM -0.672104964973643 0.256980120591342 no 2508 0.250758437971179 3594 5280953 A monoamine oxidase inhibitor
SGTC_899 1083-0020 478 µM -0.67269686652837 0.256796156374789 no 2509 0.250570080746448 3667 767123
SGTC_3311 9131146 2.8755 µM -0.673678729217783 0.256491142673066 no 2510 0.250257793942082 3624 4900406 YPR165W RHO1
SGTC_2825 7998094 58.44 µM -0.67381703689688 0.256448192836763 no 2511 0.25021382101621 3605 2987815
SGTC_961 1252-1571 372 µM -0.674490759476595 0.256239029746339 no 2512 0.249999679274407 3638 6813498
SGTC_2686 alizarin 95.37 µM -0.67504076451303 0.256068341817544 no 2513 0.249824933101849 3608 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_464 bw-b 70c 158 µM -0.676344971295839 0.255663832963324 no 2514 0.249410823238884 3650 5353454
SGTC_858 0438-0351 2.77 µM -0.67711430685633 0.255425374729438 no 2515 0.24916671610918 3644 2799119
SGTC_109 0132-0036 33.701 µM -0.680212348718787 0.254466303501161 no 2516 0.248185007209285 3529 67274 A color developer.
SGTC_3154 9100113 49.47 µM -0.680530871685945 0.254367804362835 no 2517 0.248084190583202 3640 25237525
SGTC_2974 9094440 9.66 µM -0.681967074573267 0.253923925376796 no 2518 0.24762988531677 3691 25236134
SGTC_2832 7992762 51.95 µM -0.682374889182491 0.253797958598127 no 2519 0.247500964870208 3564 2985177
SGTC_2165 5727197 32.143 µM -0.682573984139273 0.253736473578358 no 2520 0.247438038981247 3776 1361712
SGTC_34 0469-0683 81.75 µM -0.686356723677585 0.252569765776032 no 2521 0.246244093644541 3640 3690923
SGTC_2463 5473429 200 µM -0.687061957265402 0.252352564047895 no 2522 0.246021843022134 3632 5399405
SGTC_2803 7707263 71.43 µM -0.687074637916945 0.252348659492267 no 2523 0.246017847767261 3648 2199229
SGTC_3091 9116372 49.47 µM -0.687600026243304 0.252186912842356 no 2524 0.24585234584409 3666 17169793
SGTC_2571 chrysanthemic acid 100 µM -0.688130395576019 0.252023688207565 no 2525 0.245685335491097 3621 2743 An insecticide.
SGTC_202 3594-0513 34.79 µM -0.688538834703751 0.251898026394558 no 2526 0.245556761816782 3630 708429
SGTC_3345 9148410 3.559 µM -0.689194865572102 0.251696258878678 no 2527 0.245350323732798 3622 4903596
SGTC_1861 st057647 17.4 µM -0.690754385988405 0.251216958784193 no 2528 0.244859952584878 3689 688668
SGTC_2361 9034121 116 µM -0.692758377192426 0.250601765210541 no 2529 0.244230598515458 3665 6496917
SGTC_628 1636-0253 16 µM -0.692956147267415 0.250541096224007 no 2530 0.244168536074433 3654 4456143
SGTC_2103 5378138 10 µM -0.693526223080591 0.250366260329151 no 2531 0.243989687562244 3705 244142
SGTC_5 0352-0601 109.883 µM -0.693946785498683 0.250237319992792 no 2532 0.243857790841139 3585 762456
SGTC_830 4076-0286 57.8 µM -0.694193960885096 0.25016155486247 no 2533 0.243780289691128 3715 6866659
SGTC_1555 citronellol 128 µM -0.694559101779558 0.250049652767031 no 2534 0.24366582511783 3628 8842 A terpine precursor.
SGTC_2447 5741742 33.78 µM -0.696001608936192 0.249607837832521 no 2535 0.24321391107303 3708 1776504
SGTC_247 mechlorethamine 29.705 µM -0.696416291170902 0.249480904637383 no 2536 0.243084081769293 3603 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_279 1273-0055 2.93 µM -0.696577974911601 0.249431422944563 no 2537 0.243033471750967 3707 2847562
SGTC_217 ketoconazole 989 nM -0.69771375006574 0.249083977374337 no 2538 0.242678113686172 3609 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1028 k015-0029 4.8 µM -0.698290007265911 0.248907792738186 no 2539 0.242497923616302 3672 4588309
SGTC_1464 k208-0027 110 µM -0.698827715072109 0.248743454018476 no 2540 0.242329852950483 3688 X1464
SGTC_2575 plumbagin 510 nM -0.699564757101638 0.248518287028033 no 2541 0.242099579231156 3643 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1376 2910-0861 41.3 µM -0.699835032124805 0.248435744992484 no 2542 0.242015167065094 3668 1112859
SGTC_404 fumagillin 50 µM -0.700503017673023 0.248231804793556 no 2543 0.241806610632508 3663 12015870 A methionine aminopeptidase binder.
SGTC_3014 9081533 49.47 µM -0.700679659723809 0.248177889790665 no 2544 0.241751476293904 3678 21367265
SGTC_1669 st015249 58.4 µM -0.70232631001819 0.247675596846453 no 2545 0.241237844543748 3746 722793
SGTC_2407 paclitaxel 400 µM -0.702401483622991 0.247652678913531 no 2546 0.241214410165169 3809 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_923 1900-2434 73.3 µM -0.702721728180535 0.247555059686048 no 2547 0.241114592017633 3666 5910570
SGTC_3208 9114115 49.47 µM -0.704201446328697 0.247104268525146 no 2548 0.240653665226211 3676 650895
SGTC_696 1560-0013 611 µM -0.704295227501943 0.247075713209444 no 2549 0.24062446890455 3724 1650269
SGTC_3238 9133470 49.47 µM -0.705068475820332 0.246840335063212 no 2550 0.240383811723614 3683 3534688
SGTC_1352 1496-0991 99 µM -0.705506858183354 0.246706944035938 no 2551 0.240247432744612 3674 3000039
SGTC_68 0986-0284 82.829 µM -0.705799458082891 0.246617933195047 no 2552 0.240156429567388 3681 423278 YIL048W NEO1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.706092306112749 0.246528864097282 no 2553 0.240065368033387 3618 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_390 dec-rvkr-cmk 16.7 µM -0.70645789602128 0.246417694905427 no 2554 0.239951713726968 3744 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1695 st026914 34.495 µM -0.706489129277303 0.246408198690404 no 2555 0.239942005317357 3654 3289191
SGTC_3016 9080866 49.47 µM -0.707550805098905 0.246085521546229 no 2556 0.239612126050741 3683 17066299
SGTC_3327 9140648 26.9345 µM -0.710112002741626 0.245308025743631 no 2557 0.238817341868855 3676 8029710
SGTC_3215 9129942 49.47 µM -0.710540092857163 0.245178200510492 no 2558 0.238684638856754 3626 17682944
SGTC_3261 9137475 49.47 µM -0.710791950648971 0.24510183783828 no 2559 0.238606584694136 3568 17027690
SGTC_384 k007-0144 5.16 µM -0.712067376435469 0.244715328320362 no 2560 0.238211527439724 3699 6824886
SGTC_697 0508-1955 564 µM -0.712636328913664 0.244543016863766 no 2561 0.238035412686122 3666 6243113
SGTC_339 3091-4833 71.4 µM -0.714964836973449 0.243838492602478 no 2562 0.237315385662825 3654 3240077
SGTC_1600 coumarin 106 71.1 µM -0.715397102751397 0.243707824910383 no 2563 0.237181851121757 3773 100336 A hepatotoxic, DNA x-linker.
SGTC_312 4092-0653 6.84 µM -0.715662159533363 0.243627720780105 no 2564 0.237099990815405 3702 1148278
SGTC_1302 1159-0335 255 µM -0.715812980784762 0.243582146686081 no 2565 0.237053418014382 3705 649284
SGTC_1412 3909-8563 178 µM -0.716765712500005 0.243294363421611 no 2566 0.236759335737262 3774 23767530
SGTC_2639 lactacystin 53 µM -0.716989009694008 0.243226940600661 no 2567 0.236690439023365 3726 3870 A proteasome inhibitor.
SGTC_3170 9103054 49.47 µM -0.718362056969844 0.242812581932562 no 2568 0.23626703782848 3681 16432970
SGTC_2592 piperlongumine 83.33 µM -0.718562615227347 0.242752089386472 no 2569 0.236205227395576 3706 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1739 st037196 92.5 µM -0.71869237384845 0.242712955831377 no 2570 0.236165241583532 3708 612214
SGTC_1072 oxiconazole 14.9 nM -0.719632288306942 0.242429591535528 no 2571 0.235875713271274 3717 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1354 1498-1681 81 µM -0.719974280149974 0.242326532727155 no 2572 0.235770415740813 3766 5754243
SGTC_2380 9035439 200 µM -0.719982747815508 0.242323981308106 no 2573 0.235767808918979 3788 6462575
SGTC_3095 9117207 49.47 µM -0.720411693129548 0.242194753489251 no 2574 0.235635776316229 3685 17015229
SGTC_3003 9075612 71.4286 µM -0.722981546537875 0.241421319910152 no 2575 0.234845610777578 3709 6501993
SGTC_1501 4491-0275 38.4 µM -0.723135171900505 0.241375126732103 no 2576 0.234798421263937 3700 5104718
SGTC_1839 st053978 48 µM -0.723683617739297 0.241210255273943 no 2577 0.234629996454538 3748 3788398
SGTC_1791 st048313 56.1 µM -0.723923004118326 0.241138311151188 no 2578 0.234556503117878 3654 1204976
SGTC_416 estradiol valerate 100 µM -0.724237818281834 0.241043716056419 no 2579 0.234459872296569 3731 13791 A steroid.
SGTC_3304 9125678 46.087 µM -0.72457638045194 0.240942007703545 no 2580 0.234355976714029 3713 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2836 9010338 19.48 µM -0.724933807048409 0.240834657573246 no 2581 0.23424631980225 3663 2994051
SGTC_361 000s-0510 1.45 µM -0.725130290991365 0.240775656327665 no 2582 0.23418605149128 3718 660
SGTC_1756 st041558 35.5 µM -0.725174909506513 0.240762259138085 no 2583 0.234172366670714 3771 3955792
SGTC_2518 prenyletin 46.28 µM -0.728707093728876 0.239702971009756 no 2584 0.23309042631888 3662 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2948 9070189 9.45 µM -0.72923891789235 0.239543699626448 no 2585 0.23292776446099 3630 6473636 YDL196W YDL196W
SGTC_2736 butenafine 14.65 µM -0.730857777331739 0.239059237322054 no 2586 0.232433014131043 3696 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1396 3511-0007 98.6 µM -0.731340418733193 0.238914905044823 no 2587 0.232285624083921 3686 X1396
SGTC_2952 9073731 13.78 µM -0.733163853369157 0.238370043442456 no 2588 0.23172924939323 3767 16457353
SGTC_1436 4092-1007 8.32 µM -0.735139222687304 0.237780550871976 no 2589 0.231127354515814 3718 2881121
SGTC_383 2324-0395 7.37 µM -0.735377160821693 0.237709599026889 no 2590 0.231054913702398 3758 3146421
SGTC_1008 4106-0037 6 µM -0.73634622803612 0.237420748519872 no 2591 0.230760009900939 3697 2905394
SGTC_812 4251-0442 148 µM -0.737464783082551 0.237087579795439 no 2592 0.23041987592899 3713 5723007
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.737990443483801 0.236931097285006 no 2593 0.230260128208315 3696 4620898
SGTC_2274 7947094 46.08 µM -0.738541136215676 0.236767223877552 no 2594 0.2300928396407 3726 2971028
SGTC_164 4100-3994 89.624 µM -0.740061953404814 0.236314987830278 no 2595 0.229631201596539 3744 4615967
SGTC_290 2043-6722 48.1 µM -0.740938963634388 0.236054413067246 no 2596 0.229365224648274 3736 773758 YLR208W SEC13
SGTC_1047 2043-3044 82 µM -0.741313772495091 0.235943099238628 no 2597 0.229251606470549 3744 669592
SGTC_1330 1469-0054 61.8 µM -0.741892680824634 0.235771227129529 no 2598 0.229076180360802 3755 7102664
SGTC_38 0929-0051 58.268 µM -0.745022920357559 0.234843087087647 no 2599 0.228128931978364 3762 1379719
SGTC_50 0929-0078 56.389 µM -0.745197179572223 0.234791477302193 no 2600 0.228076263828652 3652 1377751
SGTC_1837 st055472 66.5 µM -0.745397782621792 0.234732073112703 no 2601 0.228015641979446 3807 676091
SGTC_1389 3405-0187 19 µM -0.747566437340361 0.234090404398955 no 2602 0.227360857646526 3715 799890
SGTC_2017 5132927 60.65 µM -0.748386825666809 0.233847918678342 no 2603 0.227113433333125 3761 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3106 9121286 49.47 µM -0.748745113819595 0.233742061586639 no 2604 0.227005423365292 3748 15943471
SGTC_767 0929-0023 86 µM -0.748940193420365 0.233684436022045 no 2605 0.226946626620629 3819 1204563
SGTC_3042 9091578 49.47 µM -0.749296197961912 0.233579294317355 no 2606 0.22683934944443 3691 25236497
SGTC_2802 7925815 54.55 µM -0.751748017942017 0.232855891385662 no 2607 0.226101303914085 3775 1262923
SGTC_374 0880-0231 82.3 µM -0.751959687742036 0.232793497197376 no 2608 0.22603765088769 3716 6833587
SGTC_2257 7960413 200 µM -0.752565222148839 0.232615054327268 no 2609 0.225855611433514 3737 2974689 YIL048W NEO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.755114206693504 0.231864737111129 no 2610 0.225090229833148 3729 390807
SGTC_3076 9116187 49.47 µM -0.755562663741117 0.231732869209512 no 2611 0.224955724171086 3741 27241210
SGTC_2011 4012611 177 µM -0.755567655629055 0.231731401590001 no 2612 0.224954227211222 3792 2049887
SGTC_2927 9011802 47.9 µM -0.755814285862016 0.231658898530236 no 2613 0.224880275137833 3770 43912568
SGTC_1932 st074806 40.9 µM -0.75615720740526 0.231558109268933 no 2614 0.22477747302309 3841 17251235
SGTC_100 0086-0128 49.5915 µM -0.757438789329301 0.231181651536598 no 2615 0.22439351228439 3775 93297
SGTC_103 0844-0104 51.839 µM -0.759489904665602 0.23057985878597 no 2616 0.223779775405567 3765 5375804
SGTC_1214 0358-0031 63.7 µM -0.760471770228827 0.230292091698336 no 2617 0.223486318613833 3879 4301366
SGTC_14 0354-0009 295 µM -0.760545854954819 0.230270386953052 no 2618 0.223464185296968 3832 1713507
SGTC_3121 9125696 49.47 µM -0.760778379598174 0.230202271190026 no 2619 0.223394725074519 3824 1235365
SGTC_3061 glucosamine 200 µM -0.762386545092479 0.229731483879748 no 2620 0.222914667107205 3686 91431 and experimental redox chemotherapeutic
SGTC_1520 flindersine 88 µM -0.76278741712752 0.229614213385149 no 2621 0.222795093245037 3878 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2790 5423970 71.43 µM -0.763037772477144 0.229540991827274 no 2622 0.222720434701961 3823 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_207 4185-0010 4.486 µM -0.763503521554436 0.229404808769654 no 2623 0.222581581475421 3842 3761753
SGTC_898 1000-0849 28.3 µM -0.764702948451149 0.229054309984248 no 2624 0.222224225040584 3720 6751807
SGTC_1344 1488-0097 29.1 µM -0.76610790803586 0.228644132368025 no 2625 0.221806048991479 3805 747966
SGTC_1677 st019204 53.9 µM -0.766874514284527 0.228420495910769 no 2626 0.221578063869498 3812 3945625
SGTC_2116 5511452 16.8835 µM -0.768741426507377 0.227876389650663 no 2627 0.221023413475331 3812 870744
SGTC_1908 st060353 56.5 µM -0.769649061553192 0.227612125676737 no 2628 0.220754046907691 3811 4227716
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.772178024177985 0.226876712333927 no 2629 0.220004497691084 3795 75037 A free radical scavenger.
SGTC_511 blebbistatin 171 µM -0.773977860039252 0.226354143878698 no 2630 0.219471942034386 3839 3476986 A myosin inhibitor.
SGTC_2688 kanamycin b 96.69 µM -0.774317982945425 0.226255468247441 no 2631 0.219371385911961 3897 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2698 st077697 67.5 µM -0.774567887188139 0.226182982126086 no 2632 0.219297519490158 3781 3154499
SGTC_1093 fluphenazine 7.97 µM -0.77537191844328 0.225949857416535 no 2633 0.219059961818061 3819 6602611 An atypical antipsychotic.
SGTC_1136 pergolide 1.05886 µM -0.776193309948104 0.225711839537727 no 2634 0.218817427799682 3799 47811 A dopamine receptor agonist.
SGTC_1057 3448-5381 134 µM -0.777476956126352 0.225340156484061 no 2635 0.218438712432911 3834 5497911
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.777665992832085 0.225285449711915 no 2636 0.218382972658567 3840 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2995 9067767 71.4286 µM -0.778000730787116 0.225188595799548 no 2637 0.218284291197514 3811 11673567
SGTC_2713 st079149 53.4 µM -0.778439841405711 0.225061578213711 no 2638 0.218154879417098 3834 3103253
SGTC_775 4577-0580 57.3 µM -0.778447070223364 0.225059487538251 no 2639 0.218152749357735 3869 2006902
SGTC_778 3456-2434 196 µM -0.778526224263236 0.225036595799663 no 2640 0.218129426437865 3835 5539063
SGTC_632 0781-2353 4.65 µM -0.780616116358984 0.224432666218957 no 2641 0.21751415501686 3860 6811515 YHR007C ERG11
SGTC_3309 9129340 25.759 µM -0.782765189387792 0.223812595133108 no 2642 0.216882506476581 3847 17158987
SGTC_1741 st038134 10.228 µM -0.783068232102122 0.2237252367573 no 2643 0.216793522532996 3851 1272587
SGTC_3132 9126706 49.47 µM -0.78339170701177 0.223632009769069 no 2644 0.216698562279065 3827 850858
SGTC_537 1334-0398 209 µM -0.78359517546534 0.223573380524804 no 2645 0.216638843803053 3780 5846986
SGTC_653 0203-0016 55.2 µM -0.786958226222112 0.222605587820071 no 2646 0.215653160270649 3844 295302
SGTC_2362 9071156 126 µM -0.788288253965543 0.22222350277265 no 2647 0.215264058342508 3819 653133
SGTC_1172 0370-0043 85 µM -0.788299902086175 0.222220158201083 no 2648 0.215260652465272 3858 376585
SGTC_1176 0848-0131 83.3 µM -0.790209421404502 0.221672258723647 no 2649 0.214702737380745 3867 6769040
SGTC_1462 k081-0014 26.5 µM -0.791315387423795 0.221355276588526 no 2650 0.214379985674846 3542 3270634
SGTC_59 0330-0160 1.33 µM -0.793173982572199 0.220823166835571 no 2651 0.213838231808307 3786 4293482
SGTC_1353 1498-1206 8.11 µM -0.795044129336851 0.220288489916125 no 2652 0.213293916327275 3865 6756808
SGTC_229 benomyl 22.8748 µM -0.796309477148306 0.219927147048422 no 2653 0.21292608923572 3848 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_679 0422-0091 41.4 µM -0.796382424232166 0.219906326068784 no 2654 0.212904895358496 3823 627384 YHR062C RPP1
SGTC_3277 9138724 49.47 µM -0.796623338092358 0.219837571075519 no 2655 0.212834909549765 3770 15943418
SGTC_2692 st077426 47.7 µM -0.797381021888768 0.219621414293605 no 2656 0.212614888908894 3808 25238571
SGTC_3119 9125183 49.47 µM -0.797910785578291 0.219470352519698 no 2657 0.212461131974571 3671 22695334
SGTC_2482 5981709 142.65 µM -0.801048938687509 0.218576735165102 no 2658 0.211551657422138 3840 877755
SGTC_1435 4092-0789 56.7 µM -0.801258569993086 0.218517115498685 no 2659 0.21149098507082 3820 2248285
SGTC_2870 9038528 12.99 µM -0.801552037086061 0.218433668457173 no 2660 0.211406065740662 3857 6463316
SGTC_943 3253-1379 105 µM -0.802918808911941 0.218045270273002 no 2661 0.211010831932602 3799 668464
SGTC_1026 k007-1105 30.6 µM -0.803433140146782 0.217899214935464 no 2662 0.210862213357744 3836 7066794
SGTC_869 0564-0080 44.1 µM -0.805082995187326 0.217431084297249 no 2663 0.210385893968106 3857 6843321
SGTC_295 k015-0027 31 µM -0.805748546986898 0.217242404800223 no 2664 0.210193925592413 3826 3887424
SGTC_2918 7977171 22.06 µM -0.806064547803085 0.217152853796125 no 2665 0.210102815955713 3763 2236483
SGTC_694 1315-0438 43.2 µM -0.809760805449137 0.216106961569825 no 2666 0.209038831604446 3810 6793154
SGTC_517 1365-0151 113 µM -0.810259191151836 0.215966162018998 no 2667 0.208895612215185 3930 768657
SGTC_2958 9077254 16.72 µM -0.810552686485628 0.215883271166268 no 2668 0.208811298519675 3878 16457351
SGTC_1892 st058411 7.36 µM -0.810877927756512 0.215791435958989 no 2669 0.208717888455815 3847 3934738
SGTC_1350 1495-0454 146 µM -0.81427884768018 0.21483250852352 no 2670 0.207742612244264 3859 1069057
SGTC_3006 9075424 71.4286 µM -0.815325786827157 0.214537811392676 no 2671 0.207442925983131 3822 7465181
SGTC_1686 st019653 115.5 µM -0.815480604969613 0.214494252441502 no 2672 0.207398630999508 3811 97252
SGTC_1453 4237-0541 195 µM -0.815584621215455 0.214464989776474 no 2673 0.207368874075577 3787 739892
SGTC_548 1436-0017 110 µM -0.815914253772749 0.214372270298941 no 2674 0.207274589607902 3920 9677137
SGTC_2751 anetholtrithion 17.25 µM -0.81809339499805 0.213759905342762 no 2675 0.206651930045088 3862 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_99 0109-0120 622.8 µM -0.81818499822132 0.213734186065803 no 2676 0.206625779970214 3860 759414
SGTC_1437 4092-1038 11.6 µM -0.81831841681773 0.213696729584132 no 2677 0.206587696319868 3863 3977136
SGTC_60 0986-0278 202 µM -0.818701904641873 0.213589088938846 no 2678 0.206478254848953 3759 3110598
SGTC_882 0843-0131 351 µM -0.818782924555706 0.213566351618753 no 2679 0.206455137419143 3830 5425421
SGTC_2862 9027634 71.43 µM -0.819132541982162 0.213468251628245 no 2680 0.206355398589092 3794 5012562
SGTC_691 1548-0686 185 µM -0.819725442666601 0.213301948253926 no 2681 0.206186321217478 3877 46495133
SGTC_2986 9022445 71.43 µM -0.821034994231865 0.212934898472904 no 2682 0.205813167803348 3824 6459286
SGTC_1497 4476-2978 41.3 µM -0.821705114244481 0.212747215453623 no 2683 0.205622373882455 3894 1528379
SGTC_1515 3460-0031 42.1 µM -0.825930445744865 0.211566037363782 no 2684 0.2044217743051 3812 2876596
SGTC_1687 st020778 55.3625 µM -0.826557298821121 0.211391130194857 no 2685 0.20424401433132 3873 4259299
SGTC_3176 9106582 49.47 µM -0.82668606208641 0.211355212617528 no 2686 0.204207511664157 3793 17018027
SGTC_1003 4049-0218 100 µM -0.826992366843871 0.211269785498033 no 2687 0.20412069396849 3888 295161
SGTC_3348 9149464 3.537 µM -0.827580772403558 0.211105738406501 no 2688 0.203953980535954 3841 1951442
SGTC_1091 telmisartan 47.6 µM -0.82791729277735 0.211011950310202 no 2689 0.203858670422409 3913 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.827945333351727 0.211004136515706 no 2690 0.203850729901464 3944 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2303 7774051 200 µM -0.828172277771029 0.210940902360837 no 2691 0.203786470636703 3825 2953184
SGTC_442 cape 100 µM -0.828360918764211 0.210888349253196 no 2692 0.203733066169969 3809 5281787
SGTC_1054 3429-0080 167 µM -0.829796750769501 0.210488595440192 no 2693 0.203326854110334 3881 1162877
SGTC_2982 9019404 25.97 µM -0.832489540246931 0.209740089100319 no 2694 0.202566339878755 3842 22333232
SGTC_2126 5251174 33.877 µM -0.835411459886135 0.208929665218797 no 2695 0.201743039816325 3884 790722
SGTC_587 k089-0003 57 µM -0.835461087871078 0.208915916347218 no 2696 0.201729073625469 3789 9659696
SGTC_3117 9124945 49.47 µM -0.839549123317597 0.207785203669245 no 2697 0.200580617682785 3804 17592065
SGTC_46 0329-0187a 2.197 µM -0.839798112570945 0.20771645253223 no 2698 0.200510795950648 3956 46494817
SGTC_2710 st078562 53.7235 µM -0.8409369120662 0.20740217751768 no 2699 0.200191639129217 3852 17250908
SGTC_2438 5259590 200 µM -0.841370627151417 0.207282558922536 no 2700 0.200070167653764 3912 1201127
SGTC_2980 9014342 25.29 µM -0.841539545610189 0.207235982262107 no 2701 0.200022870305055 3963 2996599
SGTC_1094 duloxetine 25.4 µM -0.841684280733162 0.207196078707775 no 2702 0.199982349664236 3892 60834 A selective serotonin reuptake inhibitor.
SGTC_1575 cyproterone acetate 48 µM -0.842628443735782 0.206935883975218 no 2703 0.199718139038378 3916 9880 An androgen receptor antagonist and liver toxin.
SGTC_2355 9061122 103.12 µM -0.843618890019741 0.206663142315042 no 2704 0.199441202513023 3923 5302957
SGTC_930 2810-3379 265 µM -0.844621512431017 0.206387264615477 no 2705 0.199161097030525 3929 1015764
SGTC_1233 0325-0408 14.2 µM -0.846597599646611 0.205844171432315 no 2706 0.198609726156914 3955 12874
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.846910339457302 0.205758298117166 no 2707 0.198522549474447 3967 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2393 9031399 185.94 µM -0.847085546007379 0.205710198512731 no 2708 0.198473720480581 3935 1526623 YDL150W RPC53
SGTC_2243 6634756 200 µM -0.84782508276169 0.205507246394939 no 2709 0.198267695961181 3956 885676
SGTC_1609 st001574 46.4 µM -0.847843682062265 0.205502143695662 no 2710 0.198262516122707 3888 3960012
SGTC_2217 6934799 96.0675 µM -0.848684731499527 0.205271481258399 no 2711 0.19802837223797 3826 675606
SGTC_246 cycloheximide 667 µM -0.849015529018151 0.20518080037929 no 2712 0.197936325666952 3762 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1211 1056-0033 32.3 µM -0.849059510634524 0.205168745577554 no 2713 0.197924089441534 3909 6741922
SGTC_2081 5214970 32.255 µM -0.849866966714012 0.204947506931047 no 2714 0.197699526456407 3814 2063512
SGTC_1138 3761-0006 1.03 µM -0.850091061299081 0.204886131366489 no 2715 0.197637230437512 3857 12061087
SGTC_2898 9056270 58.44 µM -0.851700579990501 0.204445633741044 no 2716 0.19719014931867 3854 19154699
SGTC_883 0850-0245 24.6 µM -0.851749109270213 0.204432360870785 no 2717 0.197176678696449 3998 6823229 YPR165W RHO1
SGTC_582 0987-0078 156 µM -0.85305477864532 0.204075449846147 no 2718 0.196814463670537 3944 1625765
SGTC_232 clozapine 119 µM -0.854203275749073 0.203761809692258 no 2719 0.19649618424481 3864 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1820 st053765 18.6 µM -0.854662963621977 0.203636355267394 no 2720 0.19636887982706 3960 3690829
SGTC_1711 st032263 62.8 µM -0.857164646344553 0.202954423350765 no 2721 0.195676948958469 3912 3958979
SGTC_2130 NSC 7 2.4545 µM -0.857900389641112 0.202754127442934 no 2722 0.195473734528429 3974 21448
SGTC_1853 st056710 91.2 µM -0.859723632196949 0.202258284212839 no 2723 0.194970702313143 4002 269167
SGTC_159 3970-0959 50 µM -0.862059491211424 0.201624092483376 no 2724 0.194327390683619 3990 6615653
SGTC_1688 st021091 57.6 µM -0.862311936585475 0.201555624314047 no 2725 0.194257942962986 3920 3656366
SGTC_599 1935-0052 86.5 µM -0.862449004415608 0.201518454648312 no 2726 0.194220241935724 3928 9557311
SGTC_1121 fusaric acid 630.51 nM -0.86306694201201 0.201350935084645 no 2727 0.194050331189287 3915 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_70 0141-0289 43.283 µM -0.864997339119543 0.200828152736841 no 2728 0.193520124625606 3940 352408
SGTC_1760 st045453 10.4495 µM -0.866242879800296 0.200491273202684 no 2729 0.193178491523618 3985 3323419 YIL048W NEO1
SGTC_352 k048-0007 5.11 µM -0.86642079288806 0.200443181030984 no 2730 0.193129722702303 3935 6811911
SGTC_1482 3346-2049 8.48 µM -0.867584603777778 0.200128759082395 no 2731 0.192810888966498 3930 3826804
SGTC_8 0354-0001 70 µM -0.869144899090614 0.199707686047006 no 2732 0.192383940569199 3918 4993152
SGTC_1955 wogonin 32.4 µM -0.869428115994709 0.199631312197535 no 2733 0.192306505094927 4015 5281703 A flavanone.
SGTC_2306 7482397 179.52 µM -0.870127922833875 0.199442673764497 no 2734 0.192115249846858 3933 891448
SGTC_1158 4092-0494 91.8 µM -0.871918483781992 0.198960502760056 no 2735 0.191626424651048 4027 1148199
SGTC_631 k072-0230 41.5 µM -0.872490446023552 0.198806630135324 no 2736 0.19147043898368 3948 5773147
SGTC_1499 4480-0877 67.3 µM -0.872752511816986 0.198736151636528 no 2737 0.191398994339999 3859 2861909
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.872765023113388 0.19873278729574 no 2738 0.191395583906251 3931 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_359 0081-0058 15.9 µM -0.872780972570863 0.198728498468616 no 2739 0.191391236323817 3960 3494159
SGTC_2037 5169046 200 µM -0.872810224138783 0.198720632834008 no 2740 0.191383262943246 4003 5718022
SGTC_102 gallobenzophenone 83.616 µM -0.872886758196076 0.198700054007163 no 2741 0.191362402283892 3920 70837
SGTC_347 4534-1311 26.2 µM -0.874181796986727 0.198352032935234 no 2742 0.191009628747522 3932 2862016
SGTC_2823 7987624 58.44 µM -0.87428866279989 0.198323330887074 no 2743 0.190980535915751 3930 2239440
SGTC_2010 4012422 159 µM -0.87545906571003 0.198009147845716 no 2744 0.190662086815829 3947 952393
SGTC_2497 7-hydroxyflavone 100 µM -0.878341384872961 0.197236700558044 no 2745 0.189879241676149 3969 5281894
SGTC_3233 9132340 49.47 µM -0.881087955318142 0.196502332086425 no 2746 0.189135107958382 3950 17682950
SGTC_2921 7974240 10.71 µM -0.881633069970899 0.196356778519302 no 2747 0.188987632845994 4033 2979074 YDR527W RBA50
SGTC_2647 atorvastatin 60.16 µM -0.881741913569762 0.196327723519245 no 2748 0.188958194826201 3924 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_760 0568-0725 82.9 µM -0.881960449491906 0.19626939482841 no 2749 0.188899097769711 3970 3916171
SGTC_2665 lovastatin 100 µM -0.883121775740448 0.19595960543224 no 2750 0.188585239976531 3978 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2480 5767542 37.17 µM -0.883232203902304 0.195930163638839 no 2751 0.188555412623496 3920 2867358
SGTC_2118 5526350 200 µM -0.885025803700133 0.195452339100498 no 2752 0.188071357239725 4006 743594
SGTC_532 1548-0774 215 µM -0.886444943825575 0.195074774620539 no 2753 0.187688904804086 4105 5932993
SGTC_2533 agelasine 13.65 µM -0.887040378366464 0.194916490443478 no 2754 0.187528580822962 4022 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_303 1348-1668 34.2 µM -0.891575442518816 0.193713500196136 no 2755 0.186310268892172 3962 5380509
SGTC_788 1182-0090 188 µM -0.893193667487207 0.193285341197287 no 2756 0.18587673434937 4028 5715185
SGTC_2336 9001819 198.65 µM -0.893477850626084 0.193210210096876 no 2757 0.18580066419773 3995 2989602
SGTC_1637 st007924 17.4 µM -0.89458929642194 0.192916542125358 no 2758 0.185503337832972 3908 683336
SGTC_3039 9090270 49.47 µM -0.894655032453005 0.192899181790107 no 2759 0.185485761834442 3958 17173750
SGTC_1588 farnesol 29.9 µM -0.89626919437553 0.192473194587694 no 2760 0.185054503879445 3960 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_969 1313-0238 134 µM -0.89666542531424 0.192368714802101 no 2761 0.18494873758755 3977 5212874
SGTC_1143 3454-2408 5.08 µM -0.897181959378078 0.192232565085382 no 2762 0.184810915084521 3879 X1143
SGTC_2906 7926292 26.41 µM -0.899475048771238 0.191628857143578 no 2763 0.184199840121183 3977 2966319
SGTC_2724 maprotiline 69.64 µM -0.901081758632853 0.191206546918727 no 2764 0.183772425459283 3891 4011 A tricyclic antidepressant.
SGTC_1381 2324-0066 62.1 µM -0.90498107523092 0.19018401933489 no 2765 0.182737706568808 4043 10885928
SGTC_1503 4585-0012 61.3 µM -0.910065451541668 0.188855788136973 no 2766 0.181393996616898 4049 2922052
SGTC_2563 tomatine 8.54 µM -0.911744975628371 0.188418291962777 no 2767 0.18095149105074 3866 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1117 retinoic acid 1.10837 µM -0.912606052754177 0.188194234142916 no 2768 0.180724884908415 4016 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1140 3229-1848 2.98 µM -0.914003313962558 0.187831007797069 no 2769 0.180357552181257 4018 2849525
SGTC_2816 7982706 58.44 µM -0.916508175810464 0.187180938726819 no 2770 0.179700210631168 4054 2981853
SGTC_2963 9082507 9 µM -0.917343878454764 0.186964364639453 no 2771 0.179481235612408 4046 16459611
SGTC_43 0570-0105 72.5 µM -0.918465095975217 0.18667404242671 no 2772 0.179187712148745 4003 1114046 YDL195W SEC31
SGTC_1710 st031758 61.5 µM -0.920064282789814 0.186260440571037 no 2773 0.178769583898654 4022 5394341
SGTC_2047 4141938 200 µM -0.92108692712654 0.185996249301263 no 2774 0.178502522450054 3991 3807862
SGTC_1698 5-fluorocytosine 1.055 µM -0.921982674609119 0.185765031706006 no 2775 0.178268806424373 4034 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2653 dihydrofissinolide 100 µM -0.92388274732519 0.185275160095639 no 2776 0.177773683290935 4043 6857746
SGTC_1141 3253-0389 52.6 µM -0.924666127964391 0.18507342476896 no 2777 0.177569801870565 3979 5402031
SGTC_2594 a-mangostin 100 µM -0.926686499906067 0.184553770884398 no 2778 0.177044664426603 4049 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_666 0272-0154 136 µM -0.927228718904775 0.184414462933726 no 2779 0.176903897399085 4017 6870312
SGTC_763 3453-1109 128 µM -0.929376465644184 0.183863302691346 no 2780 0.176347009961722 4035 1560353
SGTC_2321 7390090 138.78 µM -0.929463593252071 0.183840965457902 no 2781 0.176324442153576 4032 649046
SGTC_3150 9097574 49.47 µM -0.932214180003258 0.183136656312811 no 2782 0.175612924349695 4041 17217476
SGTC_2398 5228213 48.84 µM -0.932233485037364 0.183131719064085 no 2783 0.175607936989623 4021 80771 YMR134W ERG29
SGTC_2204 7233102 200 µM -0.933684000057977 0.182760988395787 no 2784 0.175233460356266 3900 2172480
SGTC_84 0443-0269 128.823 µM -0.934218398950698 0.182624521951736 no 2785 0.175095623388473 3877 6150058
SGTC_393 acivicin 6.25 µM -0.934786005825097 0.182479645076999 no 2786 0.174949296462335 3856 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2396 5342950 42.78 µM -0.935904486274289 0.182194372546915 no 2787 0.174661183568183 4011 1886677
SGTC_3262 9137218 49.47 µM -0.938752057939684 0.181469348050823 no 2788 0.17392902937093 3850 17650664
SGTC_1480 1070-0044 41.2 µM -0.940249083715321 0.181088913414145 no 2789 0.173544904994533 4023 3124987
SGTC_2324 6149169 200 µM -0.94088219610654 0.180928172922658 no 2790 0.173382616178483 3927 2888231
SGTC_1623 st003709 20.3 µM -0.94249899332957 0.180518091226649 no 2791 0.172968613139271 3985 16192618
SGTC_2094 5332512 191.667 µM -0.942991840161389 0.180393202428749 no 2792 0.172842538331268 4063 755774
SGTC_975 1335-0046 28.5 µM -0.945116738897063 0.17985536792675 no 2793 0.1722996402417 4033 16486740
SGTC_2 0422-0095 29 µM -0.945345826986065 0.179797443498479 no 2794 0.172241174733604 3903 6790840
SGTC_2325 6158266 200 µM -0.945350801954257 0.179796185718546 no 2795 0.172239905213795 4057 3623240
SGTC_1268 0828-0275 2.46 µM -0.946884020533002 0.179408818149969 no 2796 0.171848940687745 4085 745337
SGTC_3249 9135183 49.47 µM -0.948414338045984 0.179022707160825 no 2797 0.171459281495507 4045 4902779
SGTC_2608 thymoquinone 42.66 µM -0.949256411220796 0.17881046873628 no 2798 0.171245108496248 4023 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2486 5283202 22.39 µM -0.950152677393159 0.17858474544404 no 2799 0.171017340047098 4087 1377751
SGTC_330 1488-0319 80.1 µM -0.950441002666777 0.178512169322696 no 2800 0.170944109057285 4073 6846614
SGTC_1264 0783-0040 158 µM -0.951009399143134 0.17836914918355 no 2801 0.170799802276054 3925 2855798
SGTC_1619 st003326 88.7 µM -0.951806958432192 0.178168588771474 no 2802 0.170597446204012 4025 2849032
SGTC_2160 5660466 132.927 µM -0.954684545937291 0.17744615066921 no 2803 0.169868623678235 3915 2859134
SGTC_1413 3910-0535 34.4 µM -0.957121670690607 0.176835742201271 no 2804 0.169252923382112 4037 2876951
SGTC_1887 st057648 70.8 µM -0.957149004594462 0.1768289036171 no 2805 0.16924602604597 4051 688672
SGTC_466 geldanamycin 89.2 µM -0.959739368350804 0.176181587240101 no 2806 0.168593202151489 3956 5288382 HSP90 inhibitor.
SGTC_3168 9103419 49.47 µM -0.962059944978011 0.175602964387149 no 2807 0.168009746552536 4036 16649256
SGTC_2192 5915882 198.485 µM -0.962460813593219 0.175503132147481 no 2808 0.167909089151853 3998 2876149
SGTC_2444 5485484 36.41 µM -0.962611474333419 0.175465620929342 no 2809 0.167871268545038 4124 6790631
SGTC_1216 1165-0504 9.65 µM -0.963135008623066 0.175335311896491 no 2810 0.167739887537632 4085 6304004
SGTC_188 3229-0966 278.469 µM -0.965046760145888 0.174859993310103 no 2811 0.16726069572179 4083 5722370
SGTC_2188 6126565 140.678 µM -0.965795798914826 0.174673983066877 no 2812 0.167073185551623 3961 874518
SGTC_3056 9094900 49.47 µM -0.965818497781648 0.174668348175397 no 2813 0.167067505361262 4027 25236784
SGTC_1849 st056239 19.2 µM -0.96679200253714 0.174426788627828 no 2814 0.166824011615928 4055 5393181
SGTC_1774 st048371 48.465 µM -0.971161664906819 0.173345142874475 no 2815 0.165733890166822 4035 4242727
SGTC_1724 st037281 8.293 µM -0.972118796264482 0.173108790391722 no 2816 0.165495726113071 4026 574124 YDL195W SEC31
SGTC_1399 3562-5772 25 µM -0.972813095586378 0.172937469747145 no 2817 0.165323101456065 4012 23847490
SGTC_1671 st016596 74.5 µM -0.974147194929673 0.172608579689521 no 2818 0.164991729539284 4114 2829167
SGTC_1066 ketoconazole 628 nM -0.974506695040949 0.172520021854192 no 2819 0.164902508270062 4131 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1972 st070201 17.4 µM -0.975753051955887 0.172213223629609 no 2820 0.164593427561535 4055 2829099
SGTC_3105 9121040 49.47 µM -0.975910891378445 0.172174395361641 no 2821 0.164554312184995 3908 41448907
SGTC_2372 9071633 200 µM -0.976372455360702 0.17206088335361 no 2822 0.164439963105878 4081 21321366
SGTC_1642 st009582 77.7 µM -0.980070622395669 0.17115312181187 no 2823 0.16352562965337 4042 6739311
SGTC_2977 9011197 71.43 µM -0.981708191245251 0.170752140120715 no 2824 0.163121814407753 4165 2704722
SGTC_1384 3089-0840 101 µM -0.982155960304269 0.170642602352945 no 2825 0.163011510012678 4071 1069836
SGTC_2054 5233173 129 µM -0.985695369192765 0.169778340211157 no 2826 0.162141311287937 4104 6889
SGTC_2335 9018011 154.17 µM -0.986224872318256 0.169649286555106 no 2827 0.162011388302609 4076 6458208
SGTC_2891 9063876 19.48 µM -0.986753078472531 0.1695206117163 no 2828 0.161881851132425 4063 6472478
SGTC_1996 st072960 66.8 µM -0.988365428466796 0.169128219032715 no 2829 0.161486856236902 4120 1719405
SGTC_2129 girgensonine 121.053 µM -0.98901019815689 0.168971466789106 no 2830 0.161329076048189 4104 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2905 7799065 20.05 µM -0.990609937808266 0.168582951562139 no 2831 0.160938041600977 4002 1296806
SGTC_910 3454-3003 490 µM -0.995209255818067 0.167469155900859 no 2832 0.159817250524367 4031 820824
SGTC_1851 st056236 18.9 µM -0.997198782449451 0.166988833773531 no 2833 0.159334015920789 4098 5393171
SGTC_154 3389-1638 511.116 µM -0.997260844729717 0.166973864670517 no 2834 0.159318957065379 4088 5238686
SGTC_3320 9137005 35.139 µM -0.999708826942661 0.166384114278054 no 2835 0.158725719544452 4100 4908713
SGTC_2183 6420625 130.508 µM -1.00269156136337 0.165667355288318 no 2836 0.158004851355984 4074 2897619
SGTC_386 1509-0011 3.07 µM -1.00270594550084 0.165663903586516 no 2837 0.158001380208917 4093 3107280
SGTC_2493 resveratrol 26.09 µM -1.00590312979637 0.164897842523401 no 2838 0.15723108528307 3992 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_376 3970-0862 59.1 µM -1.00777342358847 0.164450776207254 no 2839 0.156781623595575 4139 3135186
SGTC_2801 7907800 81.82 µM -1.00838927146482 0.164303738905294 no 2840 0.156633810671973 4120 6620925
SGTC_1703 st026983 48.3 µM -1.00849887749847 0.164277578758585 no 2841 0.156607513164399 4118 1104023
SGTC_283 0987-0079 11.7 µM -1.00875467708854 0.164216536470053 no 2842 0.156546151102151 4099 411556
SGTC_1044 1222-0021 1.78 µM -1.00964944189571 0.164003131563112 no 2843 0.156331636466518 4056 4306703
SGTC_849 0386-0493 241 µM -1.01108961275354 0.16366002321528 no 2844 0.155986770715255 4070 726119
SGTC_1133 3473-0247 50 µM -1.0140296747605 0.162961026539311 no 2845 0.155284296349349 4091 711311
SGTC_3235 9132602 49.47 µM -1.01448893249651 0.162852014020856 no 2846 0.155174753907781 4115 4912240
SGTC_735 3076-0345 636 µM -1.01903160121996 0.161776290468224 no 2847 0.154093982081746 4171 2888990
SGTC_1090 efavirenz 20.7 µM -1.01981555605932 0.161591116156747 no 2848 0.15390797203867 4130 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2155 5570423 76 µM -1.02065323945464 0.161393403637815 no 2849 0.153709378031849 4062 797402
SGTC_3225 9130819 49.47 µM -1.02165308957238 0.161157622664866 no 2850 0.153472560494182 4044 4547121
SGTC_2708 st078559 56 µM -1.02177776382742 0.161128238208059 no 2851 0.153443047972518 4049 17250902
SGTC_1795 st049545 62.3 µM -1.02260411193372 0.16093356472595 no 2852 0.153247532321561 4056 5291882
SGTC_1752 st044819 83.042 µM -1.02345850045317 0.160732446899897 no 2853 0.153045555898589 4113 441209 YML126C ERG13
SGTC_1778 st046819 58.9 µM -1.02460035084117 0.160463918664335 no 2854 0.15277589945705 4165 671715
SGTC_1993 st073995 70.8 µM -1.03087348075709 0.158993902186258 no 2855 0.151300077056364 4098 3098394
SGTC_2524 avocatin b 10.57 µM -1.03090704799112 0.15898606000479 no 2856 0.151292205588873 4097 6710748
SGTC_2551 apiole 73.87 µM -1.03183736246119 0.158768815133644 no 2857 0.151074156585185 4006 10659 A possible DNA adduct former.
SGTC_31 0508-1974 57.237 µM -1.03284991197611 0.158532588188935 no 2858 0.150837070932787 4050 6810525
SGTC_1810 st050138 53 µM -1.03523524478482 0.157977003668791 no 2859 0.150279531410799 4130 3444541
SGTC_2057 5236571 38.335 µM -1.037137848321 0.157534772572661 no 2860 0.149835809203382 4117 54684039 YBR257W POP4
SGTC_3038 9091290 49.47 µM -1.04058874379403 0.156734742511467 no 2861 0.149033228780099 4163 25236843
SGTC_273 hydroxyurea 18.1 mM -1.04368141082221 0.15602003746898 no 2862 0.148316406563769 4211 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1808 st050063 61.5 µM -1.04445036865974 0.155842667822376 no 2863 0.148138535163586 4129 4011993
SGTC_3230 9131665 49.47 µM -1.04449278825826 0.155832887087368 no 2864 0.148128727034774 4100 15943720
SGTC_33 0986-0033 35.816 µM -1.04476246107937 0.155770717783504 no 2865 0.148066384278903 4095 2848082
SGTC_773 4358-1457 44.6 µM -1.04685211330034 0.155289532064187 no 2866 0.147583895351302 4148 1186886
SGTC_1704 st028805 70.8 µM -1.04767140853622 0.155101140368179 no 2867 0.147395012427218 4170 2876101
SGTC_1230 0170-0365 3.77 µM -1.04822853338273 0.154973119305616 no 2868 0.147266663666342 4195 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2937 9044753 11.33 µM -1.04826274317415 0.154965260552674 no 2869 0.14725878495851 4084 6465530 YGL099W LSG1
SGTC_1452 4194-0072 190 µM -1.04845461057287 0.154921189204673 no 2870 0.147214602050795 4201 1343545
SGTC_1165 k072-0275 30.3 µM -1.04893675168414 0.154810479424051 no 2871 0.14710361461708 4122 6153523 YGL055W OLE1
SGTC_2375 9072683 200 µM -1.04955431915362 0.154668749257842 no 2872 0.146961534415724 4219 16798029
SGTC_282 k297-0036 65.7 µM -1.05067379037392 0.154412052105839 no 2873 0.146704218792781 4146 5061378
SGTC_2175 5807670 165.306 µM -1.05087991830157 0.154364817253228 no 2874 0.146656872313947 4125 241186
SGTC_381 3461-2219 42.7 µM -1.0537780364765 0.153701716013316 no 2875 0.145992275696566 4149 2883159
SGTC_583 1488-1091 88.9 µM -1.05487336095158 0.153451593087058 no 2876 0.145741623563071 4261 4303273
SGTC_213 1246-0773 967 nM -1.05707371213535 0.152949946901719 no 2877 0.145238973770258 4156 6251622
SGTC_113 0099-0221 2.5 µM -1.0584145704748 0.152644785607164 no 2878 0.144933239789118 4101 89219
SGTC_2620 irigenin 100 µM -1.0594224580465 0.152415670063191 no 2879 0.144703713133692 4187 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_52 0329-0193 875 nM -1.05949799179805 0.15239850873851 no 2880 0.144686521668009 4243 3739292
SGTC_2502 avocadyne acetate 18.59 µM -1.06121624969436 0.15200846568284 no 2881 0.144295818122852 4082 3952079
SGTC_3114 9122766 49.47 µM -1.06176669857789 0.151883654615079 no 2882 0.144170805653043 4154 17176985
SGTC_1722 st034304 3.6505 µM -1.06217443121214 0.151791247529245 no 2883 0.144078252567402 4144 4036148 YLR033W RSC58
SGTC_1220 1838-0075 193 µM -1.06328577948631 0.151539565199567 no 2884 0.143826186039153 4058 5529645
SGTC_889 0919-1524 82.7 µM -1.06375550639048 0.151433271598364 no 2885 0.143719736095724 4186 3905452
SGTC_440 fluspirilene 35.1 µM -1.06490090360464 0.151174289736573 no 2886 0.143460388046798 4243 3396 An atypical antipsychotic.
SGTC_3351 9150312 21.596 µM -1.06549191049411 0.151040774494167 no 2887 0.143326692195912 4084 4904905
SGTC_40 0327-0103 19.753 µM -1.06568529043065 0.150997104789447 no 2888 0.143282964626981 4013 409036
SGTC_1460 k062-0059 9.15 µM -1.06767553341684 0.150548149739303 no 2889 0.142833449299258 4048 1373085
SGTC_2829 7992743 58.44 µM -1.06924638555887 0.150194428494862 no 2890 0.142479331158964 4164 16462845
SGTC_2743 auranofin 4.32 µM -1.07098607776769 0.149803335150259 no 2891 0.142087844829862 4137 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1059 3448-6867 171 µM -1.07105589159425 0.149787654768898 no 2892 0.142072149698334 4105 3934407
SGTC_2940 9060638 45.86 µM -1.07140488752495 0.149709285720203 no 2893 0.14199370809385 4155 4027022
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.0726031361968 0.149440420298763 no 2894 0.141724608511791 4097 4330530
SGTC_1129 3453-1384 223 µM -1.07329009437852 0.149286424699618 no 2895 0.141570489105169 4265 1084452
SGTC_2967 9089538 49.85 µM -1.07543915498467 0.148805353629448 no 2896 0.141089079767835 4186 728216
SGTC_2761 levamisole 97.89 µM -1.07663713934429 0.148537632910758 no 2897 0.14082120270558 4173 26879 An alkaline phosphatase inhibitor.
SGTC_1089 terbinafine 2.25 µM -1.07709552654844 0.148435279629562 no 2898 0.140718795695351 4175 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_841 0251-0215 91.2 µM -1.07778223416735 0.148282032961809 no 2899 0.140565474841429 4202 3888614
SGTC_1011 4112-3381 17.4 µM -1.0795477194405 0.147888530705292 no 2900 0.140171816532893 4253 2877139
SGTC_590 k048-0076 22.4 µM -1.08079002727168 0.147612056884047 no 2901 0.139895262792096 4210 6832814
SGTC_1548 st061468 90.8 µM -1.08389769903629 0.14692196610115 no 2902 0.139205079976382 4171 390799
SGTC_1012 4112-3522 18 µM -1.08395089189169 0.146910172941876 no 2903 0.13919328658151 4213 3112398
SGTC_1446 4239-0190 62 µM -1.08457028318688 0.146772897101533 no 2904 0.139056011312532 4188 1340085
SGTC_3071 9117417 49.47 µM -1.08471367501171 0.14674112940873 no 2905 0.139024244622024 4135 45595590 YGL055W OLE1
SGTC_2353 9059630 146.67 µM -1.08523835141106 0.146624929480062 no 2906 0.138908051147615 4212 4779114
SGTC_2522 biochanin a 4.94 µM -1.08723085273097 0.146184213434774 no 2907 0.138467399449018 4193 5280373 A possible chelator.
SGTC_2208 7283366 200 µM -1.08839169473322 0.145927860483885 no 2908 0.138211113021055 4169 898663
SGTC_497 capsazepine 133 µM -1.09505828375771 0.144461504607543 no 2909 0.136745551537149 4144 2733484 A calcium channel blocker.
SGTC_2549 cedrol 20.94 µM -1.09527140912746 0.144414790777424 no 2910 0.13669887465423 4139 6708665 A sedative which affects the nervous system.
SGTC_180 1486-1293 102.781 µM -1.09543910052195 0.144378042538283 no 2911 0.136662155987627 4086 4140536
SGTC_752 1896-0090 130 µM -1.09791511061816 0.143836178061447 no 2912 0.136120779529418 4186 772567
SGTC_683 panaxydol 45 µM -1.09804022358319 0.143808834074054 no 2913 0.13609346275291 4174 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3084 9116877 49.47 µM -1.09870333673883 0.143663966340624 no 2914 0.135948743332722 4127 27241325
SGTC_1844 rapamycin 4 nM -1.09892558049723 0.143615435659945 no 2915 0.135900263899522 4086 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3213 9129884 49.47 µM -1.09919221643601 0.143557225798534 no 2916 0.135842116541793 4188 17190742
SGTC_941 3237-0776 460 µM -1.09964932377415 0.14345747077695 no 2917 0.135742471260508 4237 760008
SGTC_98 0074-0023 107.663 µM -1.10171197144365 0.143007919097823 no 2918 0.13529345537213 4212 3563821
SGTC_2225 6654152 15.4 µM -1.1021196797535 0.142919172336262 no 2919 0.135204822374964 4093 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2787 5284540 71.43 µM -1.10451987326361 0.142397471553288 no 2920 0.134683843811126 4239 736958
SGTC_2014 4013930 200 µM -1.10536703696419 0.142213641891378 no 2921 0.134500290453786 4173 64556
SGTC_2339 9000433 200 µM -1.1061005165486 0.142054610798444 no 2922 0.13434150758825 4224 2988954
SGTC_967 1306-0166 352 µM -1.10615223555521 0.142043401766082 no 2923 0.134330316373944 4222 4437607
SGTC_208 k072-0098 12.366 µM -1.10644041280033 0.141980956229692 no 2924 0.13426797087905 4176 5948901
SGTC_2127 5253358 187.912 µM -1.1114717344263 0.140893706625845 no 2925 0.133182675030976 4101 20612
SGTC_2828 7998861 71.43 µM -1.11179046098079 0.14082502176591 no 2926 0.133114127104424 4183 2988188
SGTC_1007 4101-0031 70 µM -1.11193365746869 0.140794170640107 no 2927 0.133083338009203 4180 1146276
SGTC_2819 7996655 46.38 µM -1.11201179546865 0.140777338046276 no 2928 0.133066539396793 4158 6456960
SGTC_1164 k060-0068 93.7 µM -1.11233367773969 0.140708012129952 no 2929 0.13299735445529 4199 5963676
SGTC_3033 9090887 49.47 µM -1.11327165275309 0.14050612637783 no 2930 0.132795888602872 4217 19325384
SGTC_2077 5212015 200 µM -1.11375916695434 0.140401273596463 no 2931 0.132691259409715 4066 780900
SGTC_929 2805-0021 398 µM -1.114073127227 0.140333776295254 no 2932 0.132623908033655 4282 3098024
SGTC_2625 euphol 100 µM -1.11919982628557 0.139234721370729 no 2933 0.131527449775107 4243 6708538 A triterpene alcohol.
SGTC_2763 lisinopril 49.32 µM -1.11999249726831 0.139065313880571 no 2934 0.131358479650087 4099 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1708 st033234 31.827 µM -1.12035198664305 0.138988531050931 no 2935 0.13128189833157 4300 674664
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.12090948498175 0.138869512861541 no 2936 0.13116319654288 4177 688761
SGTC_1139 k015-0024 46.9 µM -1.12168964201723 0.138703076661421 no 2937 0.130997211057888 4243 2766652
SGTC_1270 0831-1170 17.3 µM -1.12195971238031 0.138645492388897 no 2938 0.130939784969969 4234 6764716
SGTC_1245 0418-0076 17.2 µM -1.1246358565388 0.138075766483758 no 2939 0.130371686435805 4256 6790114
SGTC_429 1112-0049 25.5 µM -1.12480721392113 0.138039340576496 no 2940 0.130335368434142 4187 2836170
SGTC_904 1141-0088 396 µM -1.12565948501353 0.137858268343854 no 2941 0.130154839495599 4225 1378119
SGTC_418 lividomycin a 100 µM -1.12853130791854 0.137249318505733 no 2942 0.129547801242507 4246 72394 An antibiotic.
SGTC_1124 fisetin 1.16336 µM -1.13180352361347 0.136557710559599 no 2943 0.128858523007665 4242 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_107 0358-0022 2.6945 µM -1.13297276820186 0.136311160698712 no 2944 0.128612844649153 4242 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2767 sibutramine 71.45 µM -1.1330662511142 0.136291461813083 no 2945 0.128593216327096 4255 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1208 2323-2347 50.3 µM -1.13390550206857 0.136114700596769 no 2946 0.12841709446883 4219 5412760
SGTC_1621 st003705 32.4 µM -1.13518751786412 0.135844988241004 no 2947 0.128148379142381 4217 24207032
SGTC_130 0136-0219 337.655 µM -1.14319489572887 0.134168667739344 no 2948 0.126478840528359 4062 234244
SGTC_3087 9117406 49.47 µM -1.14547676617777 0.133693577688167 no 2949 0.126005857245586 4262 42546093
SGTC_47 0149-0135 24.25 µM -1.14983512408309 0.132789376099175 no 2950 0.125105892787286 4255 5239155
SGTC_1944 st076371 56.9 µM -1.15022011811188 0.13270970668725 no 2951 0.125026611071757 4204 24208455
SGTC_757 1066-0008 322 µM -1.15133605540176 0.132478964297385 no 2952 0.12479700471951 4278 6842497
SGTC_717 1532-0246 73.2 µM -1.15434655067079 0.131857863484111 no 2953 0.124179059419967 4224 9561992
SGTC_676 falcarinol 140 µM -1.15535667143589 0.131649914411097 no 2954 0.123972198738292 4281 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_443 clozapine 122 µM -1.15617662272338 0.131481281186581 no 2955 0.123804459916428 4199 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_87 0100-0052 35.5 µM -1.1607131869288 0.1305509751863 no 2956 0.122879278649199 4290 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2856 9022925 19.48 µM -1.16229380355712 0.130227912464913 no 2957 0.122558071371589 4295 4944862
SGTC_2064 5220758 200 µM -1.16276695420559 0.130131312723331 no 2958 0.122462034051903 4317 788518
SGTC_1229 0139-0193 12.2 µM -1.16452083897522 0.129773667413045 no 2959 0.122106501636324 4337 3090752
SGTC_2521 angolensin 13.4 µM -1.16565801680761 0.129542142626274 no 2960 0.121876370412408 4305 821428 A flavenoid.
SGTC_1282 0886-0010 32.4 µM -1.17356589308674 0.127940045061608 no 2961 0.120284474628018 4292 2836211 YNL267W PIK1
SGTC_1611 st001856 99.4 µM -1.17398881254569 0.127854753145903 no 2962 0.120199753366709 4229 647478
SGTC_1591 genipin 88.4 µM -1.17674713787338 0.1272994395345 no 2963 0.119648223684351 4300 442424 A DNA cross-linking agent.
SGTC_672 1441-0018 53.7 µM -1.18153039811605 0.126340442418066 no 2964 0.118696042464208 4269 251141
SGTC_1910 st062352 60.4 µM -1.18176174802334 0.126294186989408 no 2965 0.118650124837783 4165 2245730
SGTC_685 1278-0033 54.9 µM -1.18230315168753 0.126185986442088 no 2966 0.118542717740723 4338 3590572
SGTC_1681 tripelennamine 100 µM -1.18283551011641 0.126079656621827 no 2967 0.118437172111776 4207 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_710 3448-4187 58 µM -1.18470991591362 0.125705772183919 no 2968 0.118066080268662 4245 3946412
SGTC_1919 st067113 52.3 µM -1.18682572404124 0.125284665792934 no 2969 0.117648184939266 4291 1268243
SGTC_810 3825-7150 143 µM -1.19898887996843 0.122882956347987 no 2970 0.115266134763725 4344 22330411 YGL099W LSG1
SGTC_808 0711-0032 135 µM -1.19899755771757 0.122881254463831 no 2971 0.115264447629647 4259 4252555
SGTC_1034 k072-0165 12.7 µM -1.2016595818659 0.122359957067061 no 2972 0.114747723398776 4318 5835461
SGTC_986 1493-0483 84 µM -1.20315965405681 0.12206688646934 no 2973 0.114457272198439 4229 40079
SGTC_1872 amphotericin b 148 nM -1.20395952031595 0.121910817455663 no 2974 0.114302612350432 4306 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_718 1130-0073 349 µM -1.20630759191871 0.121453474201933 no 2975 0.113849455731736 4313 6740020
SGTC_567 1080-0542 68.4 µM -1.20767944122677 0.121186832530763 no 2976 0.113585294459432 4171 5950415
SGTC_3201 9113999 49.47 µM -1.20780951866544 0.121161571210233 no 2977 0.113560269641298 4286 16649224
SGTC_659 k018-0002 107 µM -1.20888398617555 0.120953048940146 no 2978 0.113353709619981 4264 6797879 YHR007C ERG11
SGTC_104 0074-0074 590.992 µM -1.20985838833945 0.120764164836753 no 2979 0.113166618406881 4091 3943124
SGTC_1463 k081-0032 34.1 µM -1.21202769679841 0.120344398652216 no 2980 0.112750889348832 3885 977755
SGTC_983 1491-0821 12.2 µM -1.21282912648841 0.120189580458172 no 2981 0.112597578523629 4282 46495113
SGTC_1190 1486-1332 13 µM -1.21421666956886 0.11992187025564 no 2982 0.112332498306376 4290 4150046
SGTC_1030 k029-0042 36.7 µM -1.21465942738544 0.119836533850271 no 2983 0.112248006504114 4272 6080581
SGTC_874 0599-0792 117 µM -1.21511247127484 0.119749259251953 no 2984 0.112161598825664 4313 765305
SGTC_2748 diazoxide 86.69 µM -1.2170757452883 0.119371571174367 no 2985 0.111787699014376 4367 3019 A potassium channel activatior.
SGTC_396 dithiazanine 1.25 µM -1.21771081986127 0.119249577780812 no 2986 0.111666941961177 4281 10578 An antihelmenthic.
SGTC_2650 prasterone 100 µM -1.2213787108462 0.118546723180147 no 2987 0.110971331977522 4293 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_487 nimodipine 119 µM -1.22195645906249 0.118436280402029 no 2988 0.110862046470154 4289 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2718 lomofungin 53.02 µM -1.22262078982668 0.118309376356314 no 2989 0.110736478538598 4282 5351222 A RNA synthesis inhibitor.
SGTC_1952 st077036 64.1 µM -1.22294097209076 0.118248247757315 no 2990 0.11067599596182 4322 2937007
SGTC_3346 9158254 43.5805 µM -1.22402920899009 0.118040650555183 no 2991 0.1104706044955 4307 17639500
SGTC_1301 naphtanilide LB 4.81 µM -1.23036716900238 0.116836713897326 no 2992 0.109279820906896 4366 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2884 9058502 51.95 µM -1.23037549730824 0.11683513762909 no 2993 0.109278262265229 4337 6471554
SGTC_803 4488-1585 147 µM -1.23159131314473 0.116605186286799 no 2994 0.109050893770216 4308 747204
SGTC_1185 1319-0113 81.3 µM -1.23221146780013 0.116488018032552 no 2995 0.108935050304271 4374 4672763
SGTC_1780 st038448 24.544 µM -1.23232039278188 0.1164674470329 no 2996 0.108914712504545 4342 728868 YDL195W SEC31
SGTC_2391 6285546 200 µM -1.23399705873326 0.116151125769272 no 2997 0.108602000124607 4324 846083
SGTC_2860 9025725 38.96 µM -1.23777108406921 0.1154413469335 no 2998 0.107900476553477 4353 40546248
SGTC_106 0092-0003 11.579 µM -1.23837240736965 0.115328541675877 no 2999 0.107789003445421 4235 1072148
SGTC_7 0192-1582 4.227 µM -1.24139595253211 0.114762527016869 no 3000 0.107229756802034 4363 252616
SGTC_3291 9121177 71.43 µM -1.24166767335809 0.114711757207767 no 3001 0.107179600909218 4303 17015612
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.24297218644592 0.114468237368633 no 3002 0.106939041462532 4397 5282309
SGTC_2814 7977482 42.97 µM -1.24339840647722 0.114388752608056 no 3003 0.106860528609163 4331 6456762
SGTC_1490 4089-0339 670 nM -1.24515468227318 0.114061643480467 no 3004 0.106537448503094 4299 742542
SGTC_2965 9082772 38.63 µM -1.24756347831357 0.113614085946066 no 3005 0.106095480072544 4333 16459634
SGTC_2045 5106652 78.05 µM -1.24767019821049 0.113594286250292 no 3006 0.106075929683313 4290 673349
SGTC_2854 9024559 71.43 µM -1.24861954183717 0.113418263215225 no 3007 0.105902130675162 4341 3163529
SGTC_221 trifluoperazine 10.304 µM -1.24999978109469 0.113162692588539 no 3008 0.105649813649715 4297 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3073 9114972 49.47 µM -1.25350904906845 0.11251475364426 no 3009 0.1050102539694 4325 41905075
SGTC_227 fluconazole 33.516 µM -1.25549854137669 0.11214859998592 no 3010 0.10464891863223 4327 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.25620169890073 0.112019392159473 no 3011 0.104521425479728 4243 6708630 An antioxidant.
SGTC_3086 9117350 49.47 µM -1.25782826583027 0.111720912337476 no 3012 0.104226935466289 4273 2679265
SGTC_1259 0671-0132 43 µM -1.2578792012677 0.111711574730087 no 3013 0.104217723324649 4253 X1259
SGTC_572 0960-0087 17.7 µM -1.25887399845436 0.111529318024193 no 3014 0.104037923429085 4307 6796365
SGTC_182 3448-4371 550.524 µM -1.26129002582309 0.111087564012705 no 3015 0.10360218673067 4215 3491403
SGTC_891 0929-0073 133 µM -1.26336409167206 0.110709336050703 no 3016 0.103229181325887 4375 5603632
SGTC_299 1273-0059 1.44 µM -1.26378698510913 0.110632330334116 no 3017 0.103153246901855 4143 2848077
SGTC_491 tetrandrine 80.3 µM -1.26395312642548 0.110602087754958 no 3018 0.103123425794656 4331 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1251 0490-5699 265 µM -1.26471602438648 0.110463294085887 no 3019 0.102986571774637 4377 3883818
SGTC_1000 4048-0884 8.67 µM -1.26604160792881 0.110222428354574 no 3020 0.102749093109748 4371 13040088
SGTC_862 0452-0056 10.2 µM -1.26770019859813 0.109921584254038 no 3021 0.102452516928728 4302 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2031 5180455 200 µM -1.26806484181901 0.109855522393933 no 3022 0.102387397833601 4323 29949
SGTC_1225 1216-0074 20.6 µM -1.2694325874616 0.109607983885639 no 3023 0.102143409841596 4347 4241466
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.27260801924982 0.109034830036751 no 3024 0.101578585762638 4337 688669
SGTC_501 nsc-95397 161 µM -1.2735341574235 0.108868071950373 no 3025 0.101414279863323 4361 262093
SGTC_214 4373-3496 70 µM -1.27503275355383 0.108598627071403 no 3026 0.101148824580973 4443 3779166
SGTC_1618 st003135 44.5 µM -1.27525791079089 0.10855818569091 no 3027 0.101108984930931 4318 1270615
SGTC_1519 esterone 74 µM -1.27690544755453 0.108262594735345 no 3028 0.100817815337464 4314 698 A steroid.
SGTC_1142 3253-1408 9.78 µM -1.27757949073722 0.108141829161438 no 3029 0.10069886792369 4365 256655
SGTC_196 k015-0023 18.111 µM -1.27843548278468 0.107988604364853 no 3030 0.100547959829499 4307 5211998
SGTC_1086 cerivastatin 2.18 µM -1.28007330597781 0.107695865602498 no 3031 0.100259677891388 4341 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_598 3937-0236 20.2 µM -1.28323726789219 0.107131970060538 no 3032 0.0997044815112634 4413 1379313
SGTC_1561 5-methoxyflavone 52.9 µM -1.28403216886306 0.106990634501145 no 3033 0.0995653499484294 4312 94525
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.28412165361478 0.106974732295071 no 3034 0.0995496963167085 4350 688662
SGTC_1928 4'-methoxychalcone 40.3 µM -1.28558255039004 0.106715359528926 no 3035 0.0992943949140382 4379 641818
SGTC_2342 7990637 118.86 µM -1.2921851682255 0.105548768053958 no 3036 0.0981465134036823 4365 2033102 YER133W GLC7
SGTC_268 camptothecin 39.6153 µM -1.29539369595932 0.104985206990416 no 3037 0.0975922258125774 4342 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2667 digitoxin 100 µM -1.29924017432597 0.104312468104943 no 3038 0.0969307591593235 4308 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_522 1273-0010 11.6 µM -1.29935920706829 0.104291699546547 no 3039 0.0969103421115938 4404 5705015
SGTC_85 0868-0259 160.055 µM -1.30000651286577 0.104178811583978 no 3040 0.0967993684896972 4290 83173
SGTC_2374 9071832 200 µM -1.30371863091316 0.103533140889972 no 3041 0.0961647673451856 4299 17381698
SGTC_1830 st055982 50.3 µM -1.30820201171672 0.102757197953628 no 3042 0.0954023999680464 4353 455313 An antimicrobial agent.
SGTC_2450 5739737 12.93 µM -1.30821572370624 0.102754831306882 no 3043 0.0954000751847164 4392 2262825
SGTC_2610 ononetin 44.17 µM -1.30922173755539 0.102581304493114 no 3044 0.0952296254817366 4346 259632
SGTC_2212 7123476 200 µM -1.31197430548599 0.102107604488653 no 3045 0.0947644021124799 4383 1085715
SGTC_1420 4'-methoxyflavone 42 µM -1.3192701994355 0.10085972994337 no 3046 0.0935393984308145 4359 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1567 st069303 68.4 µM -1.33270166733485 0.0985915862819336 no 3047 0.0913148629456966 4413 5581319
SGTC_2544 sphondin 68.51 µM -1.33302867407447 0.0985368347789225 no 3048 0.0912611970629104 4347 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2445 5742597 35.57 µM -1.33363182264016 0.0984359066035053 no 3049 0.0911622742135456 4396 1774255
SGTC_603 3794-0023 45.9 µM -1.33378520138574 0.0984102529686806 no 3050 0.0911371311364564 4415 3802260
SGTC_334 1502-1024 68.5 µM -1.33932880166469 0.0974863316984111 no 3051 0.0902318282190222 4414 3296216
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.34191402631028 0.0970576483860803 no 3052 0.0898119366589335 4434 1273210
SGTC_1418 3966-3099 2.4 µM -1.34412672215223 0.0966918382895231 no 3053 0.0894537061506627 4392 740335
SGTC_77 0828-0286 12.516 µM -1.34535198243595 0.0964897103926467 no 3054 0.0892557969918636 4296 745345
SGTC_844 0330-0132 15.3 µM -1.34781126603223 0.0960849462071209 no 3055 0.0888595467237297 4453 2828079
SGTC_1257 0669-0121 16 µM -1.34907727926659 0.0958770652698894 no 3056 0.0886560726490614 4390 4307855
SGTC_1745 st081495 74 µM -1.35041836292892 0.0956572186799992 no 3057 0.0884409119454775 4257 13842402 YBL026W LSM2
SGTC_727 3032-0951 202 µM -1.35138675405295 0.0954986991184671 no 3058 0.0882857873404781 4436 3652836
SGTC_74 000s-0487 160.283 µM -1.35441936781586 0.0950035301074285 no 3059 0.087801311001822 4276 677548
SGTC_1796 st049173 110.4 µM -1.35460785079236 0.0949728169121384 no 3060 0.0877712654206312 4384 94134
SGTC_805 3852-0218 479 µM -1.36042858998362 0.0940279283053065 no 3061 0.0868471681486722 4387 6615355
SGTC_3248 9135562 49.47 µM -1.36300851512482 0.0936113512306636 no 3062 0.0864399135017177 4399 17650701
SGTC_1634 st006576 41 µM -1.36301599595676 0.0936101452954787 no 3063 0.0864387346931152 4392 3915356
SGTC_3164 9100705 49.47 µM -1.36683305284949 0.092996318144251 no 3064 0.0858388199983109 4421 17174235
SGTC_2641 levomentholum 100 µM -1.37673612771975 0.0914176700587707 no 3065 0.0842969223595283 4424 16666
SGTC_1015 4130-4525 82 µM -1.37702324397383 0.0913721990348747 no 3066 0.0842525307784796 4423 1363237
SGTC_2061 5245884 80.95 µM -1.37888988204117 0.0910769855795875 no 3067 0.0839643541114122 4389 573863
SGTC_490 phenamil 164 µM -1.37901411803597 0.0910573624853549 no 3068 0.0839452005226875 4423 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1840 st055363 71 µM -1.37921033071846 0.0910263770499807 no 3069 0.0839149568985423 4450 676033
SGTC_2545 solidagenone 89.61 µM -1.37983476288601 0.090927820271822 no 3070 0.0838187632860025 4317 6708572 An anti ulcer agent
SGTC_1926 methyl fluorone black 53.6 µM -1.37996729242905 0.0909069127596699 no 3071 0.0837983578031642 4058 72721 Reacts with homocysteine.
SGTC_179 1273-0063 6.77 µM -1.3807100128846 0.0907898091321954 no 3072 0.0836840706891643 4398 3108139
SGTC_2770 toltrazuril 17.5 µM -1.3815793039454 0.0906528915274293 no 3073 0.0835504561316702 4367 68591 Kills coccidiodes.
SGTC_3142 9086498 49.47 µM -1.38173495401036 0.0906283920647718 no 3074 0.0835265488383803 4284 25236367
SGTC_995 3931-2021 34.6 µM -1.38290000051489 0.090445168724968 no 3075 0.083347765084332 4437 730143
SGTC_1308 1187-1617 41.4 µM -1.38459644933429 0.0901788653807689 no 3076 0.0830879488949921 4457 2882570
SGTC_1205 4161-2785 76 µM -1.38568663280004 0.0900080394046926 no 3077 0.0829213058205896 4434 3498106
SGTC_345 1362-0200 395 µM -1.38766666708446 0.0896983936634703 no 3078 0.0826192852919447 4408 1419823
SGTC_105 0111-0055 734.78 µM -1.39304480051387 0.0888613373895873 no 3079 0.0818031217900781 4442 5179370
SGTC_426 0988-0037 14.6 µM -1.39363015300415 0.0887705848507963 no 3080 0.0817146590867889 4463 5383008
SGTC_542 3381-0244 89.3 µM -1.39376927233624 0.0887490260655731 no 3081 0.0816936449773096 4450 1112843
SGTC_1504 k297-0033 30 µM -1.3954878417758 0.0884830275027666 no 3082 0.0814343893171846 4317 4388117
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.39629126864014 0.0883588777901108 no 3083 0.0813134010195926 4469 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1974 st069448 26.9 µM -1.39654456241788 0.088319764439069 no 3084 0.0812752855599831 4425 6323587 YNR016C ACC1
SGTC_1811 st050069 61.5 µM -1.39691730033309 0.088262230120636 no 3085 0.0812192207491707 4416 3877702
SGTC_1726 st035556 14.5795 µM -1.39962387501581 0.0878452918106153 no 3086 0.0808129903030518 4474 5919439
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.40117202221753 0.0876074665742093 no 3087 0.0805813192486198 4440 5282362
SGTC_3103 9120822 49.47 µM -1.40145264579318 0.0875644088703862 no 3088 0.0805393793535285 4448 17141819
SGTC_495 decylubiquinone 155 µM -1.4034524743395 0.0872580207329546 no 3089 0.0802409772954583 4428 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_432 NS 1619 61.3 µM -1.40423763864396 0.0871379469728452 no 3090 0.0801240486335759 4412 4552 A K+/calcium channel activator.
SGTC_3081 9117243 49.47 µM -1.4060449654332 0.0868620247206212 no 3091 0.0798553864732823 4409 45595589
SGTC_1067 clotrimazole 1.36 µM -1.40896682171288 0.086417330207156 no 3092 0.079422489483393 4479 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_687 k029-0044 34.9 µM -1.41180378665394 0.0859871867420967 no 3093 0.0790038716036176 4504 5829338
SGTC_2888 9058547 12.99 µM -1.41716965688275 0.0851779921327812 no 3094 0.0782166654434679 4372 16476514
SGTC_1 0258-0098 57.368 µM -1.41722639764511 0.0851694659937754 no 3095 0.078208373128254 4357 6790032 YDR047W HEM12
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.42272456890367 0.08434631447132 no 3096 0.0774080077246625 4413 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_369 0957-0393 4.5 µM -1.4232262247394 0.0842715079549816 no 3097 0.0773352928268042 4443 6997992
SGTC_3124 9127567 49.47 µM -1.43110041355994 0.0831038312445984 no 3098 0.0762007193964315 4412 17592030
SGTC_592 k241-0073 46.5 µM -1.43511725913022 0.0825128731409583 no 3099 0.0756268430800418 4488 4230158
SGTC_3300 9124615 50.48 µM -1.43632324705307 0.0823360672014802 no 3100 0.0754551910113626 4484 24824903
SGTC_2591 skatole 100 µM -1.44332884041834 0.0813146381242649 no 3101 0.0744639295809074 4468 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_402 epigallocatechin gallate 10 µM -1.44377761375465 0.0812495333510115 no 3102 0.0744007705113634 4406 65064 An antioxidant.
SGTC_1307 1187-1599 12.2 µM -1.44710647246747 0.0807678339755235 no 3103 0.073933552765096 4467 1538471
SGTC_2975 9084847 53.72 µM -1.45505296759825 0.0796266655510861 no 3104 0.072827299170944 4466 27211724
SGTC_2788 5282734 71.43 µM -1.45623668172795 0.0794577256084914 no 3105 0.0726636012234439 4494 743706
SGTC_826 1683-5028 118 µM -1.45692257513783 0.0793599589567441 no 3106 0.0725688768238699 4509 722377
SGTC_458 nppb 133 µM -1.45983898411564 0.0789452730375904 no 3107 0.0721671658123542 4504 4549 A chloride channel blocker.
SGTC_1983 st071813 46.9 µM -1.46150986011297 0.0787084309141138 no 3108 0.0719377858088689 4537 11838595
SGTC_1987 st072290 61.9 µM -1.46286139447359 0.0785172488308977 no 3109 0.0717526547614876 4504 54697379
SGTC_3325 9138760 55.175 µM -1.46409125729948 0.0783435839661001 no 3110 0.0715845078653674 4420 43844959
SGTC_1333 1482-0047 286 µM -1.46495484656821 0.0782218135530172 no 3111 0.0714666187019593 4507 3811116
SGTC_2074 5212007 75.395 µM -1.47462446114773 0.0768681355502766 no 3112 0.0701567673943467 4398 758611
SGTC_76 0433-0009 400.328 µM -1.47659476669364 0.0765945038335122 no 3113 0.0698921476945741 4535 2841569
SGTC_2097 5376186 200 µM -1.47728916817238 0.0764982436438248 no 3114 0.0697990701465121 4454 742755
SGTC_435 c-PAF 6.7 µM -1.48099942678409 0.075985474394831 no 3115 0.0693033631191415 4416 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1112 tnp00069 1.16933 µM -1.48159837568317 0.0759029437032626 no 3116 0.0692235957469282 4464 145826
SGTC_1878 temozolomide 1 mM -1.48582478523635 0.0753225151026276 no 3117 0.0686627362403932 4441 5394 DNA alkylating agent.
SGTC_2109 5483026 200 µM -1.48590742982725 0.075311199034002 no 3118 0.0686518040487476 4497 759335
SGTC_2456 5770359 74.46 µM -1.4874497958245 0.0751002490569241 no 3119 0.0684480267313811 4483 3118787
SGTC_420 mitomycin C 81.9 mM -1.48745908294301 0.0750989802203851 no 3120 0.0684468011326978 4473 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_894 0960-0238 55.9 µM -1.4895229119873 0.0748174184090138 no 3121 0.0681748622748896 4489 6741907 YDL195W SEC31
SGTC_2424 5537928 59.2 µM -1.49521233124666 0.0740453990539509 no 3122 0.0674295181521838 4495 5382802
SGTC_470 aa-861 153 µM -1.49717379579344 0.0737806558319634 no 3123 0.0671740209358453 4440 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2642 cholecalciferol 100 µM -1.49772897802119 0.0737058531812963 no 3124 0.0671018398853585 4493 9821465 A vitamin D precursor, similar to steriods.
SGTC_2083 5306046 65.942 µM -1.49858440601038 0.0735907103225274 no 3125 0.0669907403311991 4478 539837
SGTC_3155 9099265 49.47 µM -1.49940687085118 0.0734801341212333 no 3126 0.0668840561091923 4465 25236499
SGTC_3344 9148862 3.898 µM -1.50794492680836 0.0723397304049652 no 3127 0.0657843114388908 4519 4905352
SGTC_1529 apigenin 74 µM -1.51299332839707 0.0716718388329733 no 3128 0.0651406767640598 4501 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1467 k284-1082 293 µM -1.51314978631183 0.0716512156532498 no 3129 0.0651208078628162 4471 3334705
SGTC_1178 0988-0033 191 µM -1.51902148060607 0.0708805371850672 no 3130 0.06437854457505 4565 5392207
SGTC_2248 tofa 1.1 µM -1.52139779824248 0.0705704542006836 no 3131 0.0640800205372384 4529 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1943 st076331 65.2 µM -1.52300502765393 0.0703613204697477 no 3132 0.0638787237945961 4495 24208415
SGTC_1183 1254-0324 198 µM -1.52391340053291 0.0702433333612409 no 3133 0.0637651727488954 4549 5799357
SGTC_4 0960-0234 25.671 µM -1.52557116436241 0.0700284013643994 no 3134 0.0635583489976946 4494 6821112
SGTC_789 1309-1135 70.6 µM -1.52596445190742 0.0699774852758876 no 3135 0.063509358870881 4490 3092424
SGTC_2294 7971431 200 µM -1.52811600201403 0.0696994436874613 no 3136 0.0632418695516411 4503 5741572
SGTC_1896 st058441 89 µM -1.53099325880547 0.0693289501631111 no 3137 0.0628855293627321 4529 688759
SGTC_1029 k015-0030 64.7 µM -1.53449585399765 0.068879983758683 no 3138 0.062453856225478 4530 2208316
SGTC_602 3130-1533 38.1 µM -1.54062276858185 0.0681000231547343 no 3139 0.0617043116013686 4552 720941
SGTC_366 0181-0206 4.31 µM -1.54533741039045 0.0675045013493362 no 3140 0.0611323355106595 4499 274874
SGTC_2246 7293507 91.5585 µM -1.54971553640559 0.0669550972347857 no 3141 0.0606049037204858 4555 887656
SGTC_1432 4049-0298 68.4 µM -1.55261091003586 0.0665936656914531 no 3142 0.0602580588129686 4538 741646
SGTC_3292 9120825 59.784 µM -1.55352481946436 0.0664798958426581 no 3143 0.0601489022627159 4493 24824900
SGTC_895 0964-0006 13.7 µM -1.55651699825176 0.0661084610921404 no 3144 0.0597926019056455 4524 6738897
SGTC_2182 6325192 200 µM -1.55674121529659 0.0660806927399892 no 3145 0.0597659694951283 4548 736248
SGTC_150 3970-0969 77.2 µM -1.56592869642199 0.0649506142122045 no 3146 0.0586826554408536 4554 6615640
SGTC_492 tmb-8 126 µM -1.56656351577968 0.0648730877043156 no 3147 0.0586083756782068 4556 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_641 4092-0595 30 µM -1.56938302725906 0.0645296262989107 no 3148 0.0582793582329433 4568 786260
SGTC_1283 0922-0125 16.4 µM -1.57067999479983 0.0643721101062892 no 3149 0.0581284991381235 4531 3360884
SGTC_2067 5224629 34.075 µM -1.57257220753697 0.0641428377486539 no 3150 0.0579089536230895 4500 2835000
SGTC_2740 felodipine 17.08 µM -1.57305925636903 0.0640839267058189 no 3151 0.0578525489953507 4591 3333 L-type calcium channel blocker
SGTC_1984 st072354 53.1 µM -1.57321988740883 0.0640645067884682 no 3152 0.0578339559525295 4418 5762938
SGTC_2910 7948405 25.97 µM -1.57420272374775 0.0639457837992617 no 3153 0.0577202949331583 4492 2971328
SGTC_2960 9079389 5.97 µM -1.57549859866388 0.0637895085059721 no 3154 0.057570700833387 4498 16457355
SGTC_1374 2889-5571 141 µM -1.5782127550379 0.0634631592211093 no 3155 0.0572583704756512 4524 2853281
SGTC_2278 7948257 134.34 µM -1.57858860274922 0.0634180700296339 no 3156 0.0572152252760485 4536 1247028
SGTC_1888 azatryptophan 97.5 µM -1.59189730889068 0.0618374871169551 no 3157 0.0557038901700457 4545 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_468 gf-109203x 121 µM -1.59311657275533 0.061694234943389 no 3158 0.0555670210762016 4623 2396 A protein kinase C inhibitor.
SGTC_3069 9117009 49.47 µM -1.59822625782035 0.0610967108642303 no 3159 0.0549963160034076 4537 41904981
SGTC_2100 5377183 190 µM -1.59824099845485 0.0610949936682532 no 3160 0.0549946763349955 4564 2844202
SGTC_2890 9046729 58.44 µM -1.60275843282812 0.0605705144010001 no 3161 0.0544939986153803 4528 903329
SGTC_1212 0520-0165 585 µM -1.60395782100706 0.0604318574933153 no 3162 0.0543616751031673 4585 5403258
SGTC_1670 st016595 4.04 µM -1.60397472870803 0.0604299046323136 no 3163 0.0543598115653047 4577 597879
SGTC_863 0466-0191 129 µM -1.61198544909086 0.0595101975712214 no 3164 0.0534825530732892 4591 765160 YPR165W RHO1
SGTC_1948 st076329 66.6 µM -1.61389859359688 0.0592921815901726 no 3165 0.0532747118924311 4479 24208413
SGTC_1359 1582-0056 520 nM -1.61517324281328 0.059147274508153 no 3166 0.0531365916323784 4587 3661189
SGTC_3274 9138298 49.47 µM -1.62021576924543 0.0585767417428839 no 3167 0.052592967576532 4517 17015756
SGTC_973 1325-0077 65.9 µM -1.62576729078721 0.0579536256610838 no 3168 0.0519995845327315 4570 2835149
SGTC_1692 fluoroquinolonic acid 71 µM -1.62944830628451 0.0575433403445289 no 3169 0.0516090748485682 4579 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1060 3448-7350 82 µM -1.63239075585914 0.0572170213659349 no 3170 0.0512985976359821 4512 570178
SGTC_1231 0242-0792 125 µM -1.63293952593514 0.0571563239679303 no 3171 0.0512408580325978 4543 3707635
SGTC_263 alizarin 107.927 µM -1.64442069125498 0.0558980215042695 no 3172 0.0500446670010558 4593 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2275 7947463 200 µM -1.64454199455182 0.055884844638059 no 3173 0.0500321486454078 4519 1225414
SGTC_2661 dactinomycin 12.96 µM -1.65196614479692 0.0550830325207627 no 3174 0.0492707263068308 4566 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3060 1327-0027 12.5 µM -1.65829536082154 0.0544066750896792 no 3175 0.0486289324721047 4499 16000455 YPR107C YTH1
SGTC_212 3807-4682 38.772 µM -1.65851592851478 0.0543832236109967 no 3176 0.048606687600869 4641 3125501 YBL034C STU1
SGTC_2894 9048625 32.47 µM -1.66036753722519 0.0541866697080302 no 3177 0.0484202683082005 4573 4092861
SGTC_1388 3346-4487 254 µM -1.66037094249976 0.0541863087463438 no 3178 0.0484199259939032 4615 3345614
SGTC_2311 7694451 200 µM -1.66098237253393 0.0541215275368538 no 3179 0.0483584935224972 4565 2163142
SGTC_2143 5623677 140.463 µM -1.66528544037667 0.0536673481533961 no 3180 0.0479279109407478 4554 5375313
SGTC_3136 9095672 49.47 µM -1.66559506968188 0.053634784241476 no 3181 0.0478970469040665 4438 17217380
SGTC_2474 5321570 43.32 µM -1.66603388820196 0.0535886602294161 no 3182 0.0478533324643586 4581 2841384
SGTC_502 l-744,832 89.3 µM -1.66789102254158 0.0533938054977717 no 3183 0.0476686810668613 4588 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_205 1486-1330 71.903 µM -1.67122302643673 0.0530456119369228 no 3184 0.0473388168397074 4661 4118834
SGTC_1470 k295-0292 231 µM -1.6759169421812 0.0525581566849776 no 3185 0.0468772313405203 4628 5045612
SGTC_1859 st055998 20 µM -1.67677690300072 0.0524692377520646 no 3186 0.0467930579495444 4503 676301
SGTC_3009 9080819 71.4286 µM -1.67804099567097 0.052338748894395 no 3187 0.0466695480781753 4586 17027216
SGTC_75 0159-0059 199.013 µM -1.67926763420194 0.0522123727883249 no 3188 0.0465499479119019 4604 5377270
SGTC_739 1486-1183 203 µM -1.68737016825026 0.0513836750419449 no 3189 0.0457660981607843 4574 4346692
SGTC_815 1582-0027 36.9 µM -1.68821367721837 0.0512980086501183 no 3190 0.0456851093288081 4590 3128206
SGTC_163 TUB2.036 7.546 µM -1.69232807611207 0.0508817796639816 no 3191 0.0452917187396113 4534 15992207 YJR013W GPI14
SGTC_2073 5212005 126 µM -1.69429202070914 0.0506840494729949 no 3192 0.0451049030364762 4525 691789
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.70566490465721 0.0495510307624867 no 3193 0.0440352437368423 4578 61125 An anti-inflammatory.
SGTC_234 nsc-17383 10.7 µM -1.70995020510578 0.0491293891493432 no 3194 0.0436375407128157 4602 408974
SGTC_864 0469-0573 172 µM -1.71338354719899 0.0487936457261741 no 3195 0.0433210005582682 4578 689425
SGTC_2909 7941780 10.49 µM -1.71757502994444 0.0483862529780558 no 3196 0.0429370790516798 4552 1243215
SGTC_1346 1488-2224 62.4 µM -1.72063903190758 0.0480901709228498 no 3197 0.042658173022713 4608 3722427
SGTC_1646 st011709 75.6 µM -1.72145459669588 0.048011605696119 no 3198 0.0425841821815358 4576 5757843
SGTC_2462 5162487 171.77 µM -1.72149582747864 0.0480076365698498 no 3199 0.0425804443406342 4573 2259986
SGTC_127 0180-0333 59.125 µM -1.72244922324575 0.0479159301125809 no 3200 0.0424940867284981 4515 771601
SGTC_3047 9092122 49.47 µM -1.72343472271514 0.0478212830745161 no 3201 0.0424049701294908 4575 17173831
SGTC_254 nsc-64875 3.808 µM -1.72349339066435 0.0478156533484005 no 3202 0.0423996696840763 4600 56993
SGTC_2601 securinine 100 µM -1.72534503598728 0.0476382435541568 no 3203 0.0422326551525653 4547 442872 A GABA receptor antagonist.
SGTC_571 k831-0106 44.2 µM -1.72616264306492 0.0475600749780967 no 3204 0.042159078317106 4497 4783639
SGTC_23 0213-0011 39.996 µM -1.72843510144045 0.0473433526641293 no 3205 0.0419551234548641 4598 627608
SGTC_2018 5133068 143 µM -1.73175006147518 0.0470286279317363 no 3206 0.0416590365360426 4570 785362
SGTC_2345 9052315 157.45 µM -1.73450827018129 0.0467680421313551 no 3207 0.0414139698215043 4581 6469265
SGTC_1252 0493-0875 34.8 µM -1.73686632143324 0.0465461813758967 no 3208 0.0412053846290096 4578 3960963
SGTC_1343 1487-0095 224 µM -1.73695417465696 0.046537931924044 no 3209 0.0411976299192301 4590 4560101 YGL055W OLE1
SGTC_1391 3442-0225 151 µM -1.73775668677558 0.0464626300277959 no 3210 0.0411268477918564 4602 5227075
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.74028352579562 0.0462261684446103 no 3211 0.0409046226675164 4578 16623 A steroid.
SGTC_2218 6965428 192.983 µM -1.74248256418919 0.0460211697922772 no 3212 0.0407120198994087 4523 675684
SGTC_480 am 92016 50 µM -1.7466758910599 0.045632284164698 no 3213 0.0403467873312438 4616 2129 K+ channel blocker.
SGTC_3217 9129673 49.47 µM -1.74780455118164 0.045528065633036 no 3214 0.0402489384895896 4567 17248312
SGTC_65 0798-0905 34.986 µM -1.74831046059158 0.04548141299242 no 3215 0.0402051414341239 4573 3602145
SGTC_960 1222-0186 7.7 µM -1.75550746846691 0.0448218923894466 no 3216 0.039586272155856 4600 3126296
SGTC_2430 5571206 200 µM -1.75778234977076 0.0446150354447074 no 3217 0.039392274824305 4585 1731771
SGTC_2309 7664088 163.95 µM -1.7606436704152 0.044355945661653 no 3218 0.0391493661528675 4579 704922
SGTC_1207 2099-0101 141 µM -1.77901117719929 0.0427215312354655 no 3219 0.0376189647555633 4614 5837381
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.78012184583158 0.042624281506049 no 3220 0.0375280110562663 4632 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1799 st045822 46.1415 µM -1.79383815583856 0.0414379790390823 no 3221 0.0364195024273004 4613 3674992
SGTC_3272 9137413 49.47 µM -1.79705814716581 0.0411634006316858 no 3222 0.0361631945570185 4573 17614870
SGTC_1221 2958-7315 257 µM -1.79873841355934 0.0410207060450997 no 3223 0.0360300347127026 4663 4562705
SGTC_1309 pyrazolanthrone 13.4 µM -1.80590544678945 0.0404165532110689 no 3224 0.0354665550840283 4626 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_357 1325-0123 420 µM -1.80947625837329 0.0401182554881635 no 3225 0.0351885226584412 4611 1098503
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.82005392181978 0.039245104607874 no 3226 0.0343753968634695 4646 94937 An inhibitor of serotonin biosynthesis.
SGTC_1855 st056195 39.6 µM -1.82122743030099 0.039149195797057 no 3227 0.0342861462221316 4575 4028379
SGTC_3013 9080133 71.4286 µM -1.83860042399034 0.0377515219765105 no 3228 0.0329869894400243 4657 17050193
SGTC_2352 9027995 87.8 µM -1.84081036088709 0.037576687146535 no 3229 0.0328246769825959 4607 2997347
SGTC_1188 1403-0014 4.57 µM -1.84263719721732 0.0374326602075404 no 3230 0.0326909995700234 4669 9614867
SGTC_643 k048-0106 28.4 µM -1.84520401218815 0.0372310558054862 no 3231 0.0325039335457004 4668 6763920
SGTC_1390 3413-2614 145 µM -1.8467961113298 0.037106454554666 no 3232 0.0323883478456671 4641 3421432
SGTC_2953 9074162 66.49 µM -1.86657163661763 0.0355869979444892 no 3233 0.0309807157673168 4626 16451992
SGTC_2139 5578692 56.4705 µM -1.86717897111559 0.0355411528224244 no 3234 0.0309382996035014 4639 650991 YMR113W FOL3
SGTC_549 1661-1316 519 µM -1.86757925043147 0.03551096390388 no 3235 0.0309103704323149 4674 2857282
SGTC_2195 6536160 144.242 µM -1.86773723607938 0.035499054472406 no 3236 0.0308993528542254 4659 3834386
SGTC_2238 6671620 73.2395 µM -1.87075715336729 0.0352720329465126 no 3237 0.0306893744687879 4564 729941
SGTC_3190 9110366 49.47 µM -1.8708401456627 0.0352658108743384 no 3238 0.0306836206403352 4658 17123768
SGTC_825 1988-2224 89.6 µM -1.87658761558097 0.0348370985910892 no 3239 0.0302873180279312 4650 1180859
SGTC_759 3486-0358 89.3 µM -1.88574024099596 0.0341632299197863 no 3240 0.0296649836624706 4631 875103
SGTC_2161 5662504 8.5105 µM -1.88889581375796 0.0339333975269453 no 3241 0.0294528952641289 4660 2859334
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.90124280840409 0.0330463102369507 no 3242 0.0286351081561534 4644 688798
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.90898378052648 0.0324999586148425 no 3243 0.0281320920169574 4619 6708760
SGTC_2277 7947813 106.88 µM -1.91167831833197 0.0323115373576722 no 3244 0.0279587334870886 4662 1246798
SGTC_527 4476-4215 268 µM -1.92371041518595 0.0314811358499724 no 3245 0.027195445903686 4660 4418754
SGTC_1189 1431-2119 7.28 µM -1.92892915383219 0.0311264878557751 no 3246 0.0268698289832128 4669 3107275
SGTC_2300 7976697 71.57 µM -1.93209069446495 0.0309132523590007 no 3247 0.0266741563452038 4579 2236109
SGTC_2747 doxorubicin 7.63 µM -1.93380259154061 0.030798296024349 no 3248 0.0265687020251263 4734 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_321 4534-3890 65.3 µM -1.9371184982932 0.030576634729556 no 3249 0.0263654299486701 4672 699746
SGTC_2815 7968870 71.43 µM -1.93758751457758 0.0305453889183939 no 3250 0.0263367834666043 4601 2977326 YHR190W ERG9
SGTC_732 3970-1727 52.7 µM -1.9378451997397 0.0305282332222755 no 3251 0.0263210557008156 4700 1275699
SGTC_3200 9114385 49.47 µM -1.94721454617723 0.0299098579290431 no 3252 0.0257545092463729 4641 17018030 YLR208W SEC13
SGTC_3040 9091894 49.47 µM -1.94805382557603 0.0298549762614538 no 3253 0.0257042614972244 4599 25236966
SGTC_3315 9136395 68.55 µM -1.94814647588396 0.0298489228496922 no 3254 0.0256987195459987 4668 16876844
SGTC_2268 7933382 153.85 µM -1.95551444341984 0.0293707781673243 no 3255 0.0252611901378039 4689 935025 YOR257W CDC31
SGTC_1931 st074438 57.1 µM -1.95570681315591 0.0293583800169654 no 3256 0.0252498508415758 4671 2787313
SGTC_644 1498-1197 63.3 µM -1.95724817665217 0.0292591966062102 no 3257 0.0251591485752778 4699 6741615
SGTC_3236 9132701 49.47 µM -1.96114095999755 0.0290099428348004 no 3258 0.0249312908836784 4694 24282524
SGTC_1779 st039427 55 µM -1.98438620299617 0.0275580246754994 no 3259 0.0236064014560972 4659 1124498
SGTC_1556 plumbagin 1.48 µM -1.98486382788604 0.0275288388414545 no 3260 0.0235798118884815 4617 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2700 st077718 96.8 µM -1.99590197524222 0.026861486285787 no 3261 0.0229722968386477 4655 904970
SGTC_66 0109-0187 42.4 µM -2.01308405231561 0.0258495890220711 no 3262 0.0220528938280201 4521 759417
SGTC_272 doxorubicin 8.13 µM -2.02755648538767 0.025022202871153 no 3263 0.0213027669838588 4710 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1758 st042942 75.2445 µM -2.03908586432104 0.0243790636059441 no 3264 0.0207207293705826 4666 669317
SGTC_1988 st071872 53.4 µM -2.05553924899404 0.0234853291898739 no 3265 0.0199134743709338 4722 16414116
SGTC_3283 9109332 35.8195 µM -2.05885300454372 0.0233087040905557 no 3266 0.0197541611151848 4555 17027281
SGTC_907 3448-6986 75.5 µM -2.06976442375213 0.022735001208217 no 3267 0.0192372052180099 4695 590582
SGTC_2636 apigenin dimethyl ether 100 µM -2.07195476865912 0.0226212826469947 no 3268 0.019134829793094 4652 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_658 3253-0951 102 µM -2.0764851056571 0.0223875971339773 no 3269 0.018924553630822 4708 1184878
SGTC_2791 5663188 71.43 µM -2.08164221610966 0.0221240626172749 no 3270 0.0186875811529065 4668 54690634
SGTC_3231 9132313 49.47 µM -2.0928542825349 0.0215601364476799 no 3271 0.0181810821992371 4698 4905967
SGTC_3116 9124943 49.47 µM -2.09921579843766 0.0212456112462589 no 3272 0.0178989409806774 4695 41905195 YPL160W CDC60
SGTC_559 1550-0661 158 µM -2.10465614191277 0.0209797173347809 no 3273 0.0176606254040924 4719 5830875
SGTC_2252 omeprazole 400 µM -2.1114262654065 0.0206527690959316 no 3274 0.0173678447251719 4744 4594 A proton pump inhibitor.
SGTC_3008 9078912 71.4286 µM -2.11357295097448 0.0205500049970738 no 3275 0.0172758790722339 4703 16648731
SGTC_1290 0986-0249 10.2 µM -2.12477856917361 0.0200205863795693 no 3276 0.0168025469344572 4624 53329
SGTC_2941 9056145 11.23 µM -2.12528695320417 0.0199968442868497 no 3277 0.0167813381275781 4682 2119517
SGTC_1782 st039423 80.636 µM -2.13410674181976 0.019588736938132 no 3278 0.0164170220712937 4698 2068169
SGTC_1417 3966-0327 90.4 µM -2.14644800018326 0.0190295731434897 no 3279 0.0159186266180289 4757 651118
SGTC_618 k072-0232 33.2 µM -2.15588047414034 0.0186114067317641 no 3280 0.0155464997580321 4726 5872756 YGL099W LSG1
SGTC_2096 5468907 200 µM -2.19177926470983 0.0170907221218313 no 3281 0.0141977245207842 4740 759785
SGTC_2460 5552655 174.22 µM -2.19360770168878 0.0170161972737147 no 3282 0.014131812132324 4703 5401989
SGTC_1979 st071809 45.3 µM -2.21527586602916 0.0161539740614879 no 3283 0.0133705676583276 4747 4976333
SGTC_1560 lithocholic acid 53.1 µM -2.21725731043207 0.0160770298074224 no 3284 0.0133027566419071 4701 9903 A bile acid which acts as a detergent.
SGTC_1716 st033144 30.6155 µM -2.22194507498729 0.0158962421990974 no 3285 0.0131435088479068 4689 674617
SGTC_3100 9120536 49.47 µM -2.22223194304663 0.0158852357138253 no 3286 0.0131338173868358 4680 16421196
SGTC_258 haloperidol 50.781 µM -2.22717199268139 0.0156967197501637 no 3287 0.0129678905884823 4726 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1813 st051246 8.6015 µM -2.23040857778864 0.0155742526208382 no 3288 0.0128601653169115 4720 5291959
SGTC_1738 st035555 74 µM -2.27135435185692 0.0140943749588146 no 3289 0.0115627677110653 4710 5331140
SGTC_1976 st070609 63.5 µM -2.28707503356943 0.013559277033556 no 3290 0.0110957219299694 4720 682556
SGTC_1068 loratadine 26.9 µM -2.28937674748406 0.0134824221553314 no 3291 0.0110287359834791 4752 3957 A H1 histamine antagonist.
SGTC_1552 6-methylflavone 10.6 µM -2.30334432195519 0.0130240594851982 no 3292 0.0106297388775931 4726 689013
SGTC_3297 9117502 71.43 µM -2.31850170524667 0.0125419535410389 no 3293 0.0102110351959594 4747 7453720
SGTC_936 3005-4620 401 µM -2.31957779590426 0.0125083217753449 no 3294 0.0101818640815506 4744 777207
SGTC_335 4077-0256 27.6 µM -2.32265858158605 0.0124124674044921 no 3295 0.0100987504842852 4651 3121989
SGTC_2282 7944268 200 µM -2.33342483761885 0.0120824696218579 no 3296 0.00981292946955357 4718 2970414
SGTC_3214 9129694 49.47 µM -2.33614192229556 0.0120003998693 no 3297 0.00974192300699776 4718 17158655
SGTC_3199 9111318 49.47 µM -2.33815565889989 0.0119398871168825 no 3298 0.00968958738393968 4670 8548020
SGTC_2221 6807166 181.081 µM -2.33978121917936 0.0118912322833405 no 3299 0.00964751956291035 4752 674925
SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.34427363540082 0.0117576627038308 no 3300 0.00953208948354365 4742 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2186 6124449 200 µM -2.34753657676184 0.0116614662686301 no 3301 0.00944900878502961 4753 3834182 YLR033W RSC58
SGTC_230 MPP+ 141.667 µM -2.35026662725567 0.0115815059655463 no 3302 0.00937998377620898 4750 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2495 cafestol 54.53 µM -2.3537286169784 0.0114807929073055 no 3303 0.00929308742092533 4725 16667697 An anti-infammatory.
SGTC_2772 vinpocetine 57.06 µM -2.35636753803414 0.0114045355870742 no 3304 0.00922732408463129 4726 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_661 1304-0007 33.6 µM -2.35844184296679 0.0113449033485136 no 3305 0.00917591755239076 4761 3117130
SGTC_1565 sinapyl alcohol 95.1 µM -2.38203842897364 0.0106853918430728 no 3306 0.00860855032115954 4739 5280507 A phenol propionate derived from cinnamic acid.
SGTC_964 1287-0107 19.4 µM -2.39722000466224 0.010278949591495 no 3307 0.00826000068445209 4741 51516812 YPR165W RHO1
SGTC_827 3253-0474 693 µM -2.40005862668809 0.0102044684039273 no 3308 0.00819622309981645 4759 5402065
SGTC_3339 9145883 14.936 µM -2.40112991809992 0.010176481920686 no 3309 0.00817226622357446 4718 2030670
SGTC_1284 0929-0043 16 µM -2.43581769722861 0.00930576119235764 no 3310 0.00742908532700262 4759 1239883
SGTC_181 1447-1644 8.07 µM -2.45110985687784 0.00894308158325301 no 3311 0.0071208240217045 4725 534600
SGTC_2066 5222451 176 µM -2.47341244441 0.00843634931674931 no 3312 0.00669147962580505 4725 2281147
SGTC_1055 3448-0672 86 µM -2.4769671712386 0.00835795580989884 no 3313 0.00662520445221637 4738 748378
SGTC_1729 st035615 45.989 µM -2.5065053362816 0.00773090341731183 no 3314 0.00609656085881496 4736 17385451
SGTC_2115 tiliquinol 12.7705 µM -2.51308840475626 0.00759693215939134 no 3315 0.00598396700625621 4747 71208 A bioactive hydroxyquinoline.
SGTC_566 0958-0068 16.5 µM -2.52822360737171 0.00729664388990364 no 3316 0.00573206558546787 4732 6815365
SGTC_886 0866-0150 153 µM -2.52898412637466 0.00728183492973282 no 3317 0.00571966003565748 4773 271463
SGTC_1574 spiramycin 23.7 µM -2.5370538953092 0.00712632394827315 no 3318 0.00558948712659033 4740 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1949 st076024 69.1 µM -2.54944101655779 0.00689331295612957 no 3319 0.00539478804064339 4735 2921930
SGTC_2489 cantharidin 73.42 µM -2.55928348722058 0.00671299205588263 no 3320 0.00524440847251169 4750 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1553 gossypol 38.6 µM -2.6115001986497 0.00582434815962964 no 3321 0.00450729677582596 4774 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3129 9127257 49.47 µM -2.61866180160121 0.00571098631760948 no 3322 0.00441377084468449 4734 837894
SGTC_3032 9089427 49.47 µM -2.62798951492688 0.00556627565136096 no 3323 0.00429455815445874 4745 17173707
SGTC_183 3914-0051 30.55 µM -2.65166439147487 0.00521350478799063 no 3324 0.00400480557501488 4762 1596232
SGTC_2415 st077333 57.7 µM -2.66678844100532 0.00499869554367058 no 3325 0.00382899305422867 4753 2766255
SGTC_1792 st045773 43.6 µM -2.67685188232466 0.00486016617461337 no 3326 0.00371587405601418 4768 2919270
SGTC_1081 sertraline 6 µM -2.69431878331437 0.00462782984518896 no 3327 0.0035266334706228 4771 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2655 perillic acid 100 µM -2.72509738103408 0.00424244583131386 no 3328 0.00321412621257408 4795 5702197 An apoptosis inducer.
SGTC_751 0833-0568 350 µM -2.72557433459528 0.00423670663653165 no 3329 0.00320948603382522 4781 6954252
SGTC_820 1582-0060 59.9 µM -2.73465294273686 0.00412877933029538 no 3330 0.00312230388794911 4785 3848840
SGTC_2125 5246583 200 µM -2.73767075651267 0.00409345195884214 no 3331 0.00309379941480209 4760 835267
SGTC_251 melphalan 456.522 µM -2.7764382719341 0.00366309281554811 no 3332 0.0027479034904533 4787 460612 A DNA alkylator.
SGTC_2002 4023503 131 µM -2.82497009040815 0.00318177894744453 no 3333 0.00236425148435814 4774 4736863 YCR052W RSC6
SGTC_2085 5307070 144.047 µM -2.8726844776456 0.00276483681519437 no 3334 0.00203500188949101 4768 2840351
SGTC_561 1550-0330 72.9 µM -2.88663352753271 0.00265262789416889 no 3335 0.0019469374090389 4780 6812934
SGTC_1654 st012436 41.8 µM -2.89711441550703 0.00257104184170929 no 3336 0.00188306188082916 4796 4323132
SGTC_3338 9144300 39.5675 µM -3.04786061293883 0.00162344720450227 no 3337 0.00115238403016646 4789 4901274
SGTC_3049 9092223 49.47 µM -3.04877477482117 0.00161883057633166 no 3338 0.00114888337884141 4782 8623917
SGTC_2285 7945142 200 µM -3.06205221836161 0.00155311292802393 no 3339 0.00109912550216697 4777 2970608
SGTC_2585 alliin 100 µM -3.06977594771588 0.00151601211855778 no 3340 0.00107109704372682 4779 87310 A garlic compound which reacts with lipids.
SGTC_3127 9126946 49.47 µM -3.07533460054999 0.00148981342496623 no 3341 0.00105133258246693 4776 27243249
SGTC_1540 guanosine 70.6 µM -3.22160967849054 0.000932692745643934 yes 3342 0.000637363313520156 4798 6802 Guanosine is a purine nucleoside
SGTC_875 0709-0210 25.7 µM -3.26422467153422 0.000810903056157176 yes 3343 0.000548820437482085 4800 6251364
SGTC_749 1000-0129 128 µM -3.324959986623 0.000662484429338253 yes 3344 0.00044215612721068 4800 708470
SGTC_2298 7976326 193.81 µM -3.37720631512327 0.000555313763110926 yes 3345 0.000366130515079611 4796 2235818
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -3.38286527090552 0.000544722947646739 yes 3346 0.000358669070349906 4774 6728940
SGTC_1562 morin hydrate 59.1 µM -3.45686653541634 0.000422377857427866 yes 3347 0.000273247719739221 4796 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_741 4582-0002 126 µM -3.54587635271932 0.000309079228152311 yes 3348 0.000195654885095933 4805 2912688
SGTC_944 3370-0224 231 µM -3.68202243704452 0.000189141381877793 yes 3349 0.00011569552027878 4798 4580514
SGTC_2177 5811945 192 µM -3.92850405881632 7.45866305137052e-05 yes 3350 4.2737954203305e-05 4805 5343475
SGTC_1798 st045719 60.953 µM -3.99772423211356 5.68834777739191e-05 yes 3351 3.19771985598629e-05 4806 3980186
SGTC_737 1950-0117 57.9 µM -4.1429181942901 3.17817319976516e-05 yes 3352 1.71457144925403e-05 4805 5393513
SGTC_2292 7671323 168.05 µM -4.33006144306343 1.46001050294774e-05 yes 3353 7.45338713965593e-06 4808 937504
SGTC_2295 7971645 200 µM -5.29819520989724 1.58480802930461e-07 yes 3354 5.84764482356882e-08 4809 2978226 YKL099C UTP11
SGTC_991 3996-0057 64.7 µM -5.6425843786576 2.58844546601143e-08 yes 3355 8.37581960195628e-09 4809 715343
SGTC_1082 camptothecin 424.86 nM -5.84052713172071 8.70337953524643e-09 yes 3356 2.60179547997271e-09 4805 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.