SGTCid condition conc unit YJL171C|YJL171C.score YJL171C|YJL171C.strain.pval YJL171C|YJL171C.strain.significant YJL171C|YJL171C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 3.48586549237485 7.39216031763782e-05 yes 1 0.000245273796708078 17 4000243 SGTC_1295 1013-0063 9.78 µM 3.45531571393101 8.42788604238395e-05 yes 2 0.000274824397093751 27 6826038 SGTC_2788 5282734 71.43 µM 3.43912296483339 9.03077454418357e-05 yes 3 0.000291801042713911 71 743706 SGTC_1679 SEC14.276 6.7 µM 3.29629672366333 0.000164078361249287 yes 4 0.000489842414919754 107 1005053 YMR079W SEC14 SGTC_2557 derrustone 83.84 µM 3.28430155099516 0.000172343352731193 yes 5 0.000511177347109335 63 629853 An antioxidant. SGTC_2255 7941087 197.44 µM 3.17425909869152 0.000268564301050246 yes 6 0.000751097650136494 63 935561 SGTC_1251 0490-5699 265 µM 3.15971395864675 0.000284504189010495 yes 7 0.000789620494508958 72 3883818 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.15280314202124 0.000292382525171507 yes 8 0.000808554099262325 37 688801 SGTC_261 5-fluorouridine 15.376 µM 3.07534397802411 0.000395719517588351 yes 9 0.00105129952421166 52 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1409 3909-8004 61.9 µM 2.99612367532221 0.000535694966618864 yes 10 0.00136717754864779 79 2119279 SGTC_1105 epirubicin 18.1 µM 2.94579084728169 0.000647095113408504 yes 11 0.00161065069203837 63 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2914 7968218 45.32 µM 2.93069525806936 0.000684458061184831 yes 12 0.00169102187559478 36 2977111 SGTC_2594 a-mangostin 100 µM 2.92426710840168 0.000700964301564728 yes 13 0.0017263416670594 83 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_342 k048-0088 23.3 µM 2.86309094815929 0.000877460540090051 yes 14 0.00209765061535266 59 6820570 SGTC_1411 3909-8223 150 µM 2.83200062985197 0.000982040516397314 yes 15 0.00231288787748474 44 X1411 SGTC_2032 5185112 25.99 µM 2.76957859356825 0.00122733298777326 no 16 0.00280644303685131 65 5718189 SGTC_2302 7771753 200 µM 2.74170208305611 0.00135401890049205 no 17 0.00305608751079573 127 2203047 SGTC_576 1073-0113 22.7 µM 2.73980019026071 0.00136308306475512 no 18 0.00307382727932855 176 5439563 SGTC_1227 3909-8010 46.6 µM 2.69600854895486 0.00158773855069716 no 19 0.00350879328124529 96 15982272 SGTC_1106 tegaserod maleate 11.7 µM 2.62760359612856 0.00200682112197786 no 20 0.00429943272065505 117 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1414 3917-0015 5.4 µM 2.61220581843306 0.00211403007261549 no 21 0.0044980038814698 78 6618702 SGTC_259 usnic acid 108.925 µM 2.58205524270786 0.00233912916942827 no 22 0.00491069311823274 97 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2616 abietic acid 100 µM 2.54049615135883 0.00268498244954613 no 23 0.00553476559790176 117 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1200 1643-0193 18.4 µM 2.53066190606053 0.00277330100070551 no 24 0.00569237641800164 97 5403974 SGTC_2523 spermine 47.74 µM 2.52309212718564 0.00284305946154134 no 25 0.00581639603202876 103 1103 A DNA binding polyamine. SGTC_266 formosanin C 406 nM 2.50507418001998 0.0030155105052418 no 26 0.00612128570687727 181 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_310 1273-0058 1.06 µM 2.47699733126473 0.00330306976091861 no 27 0.00662464463315936 444 2734232 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.47529292979168 0.00332129499963931 no 28 0.0066563467678832 91 2724278 An inhibitor of dopamine biosynthesis. SGTC_2025 5147754 141 µM 2.4414265263163 0.00370267841014386 no 29 0.00731468244087204 81 315777 YLR208W SEC13 SGTC_1134 3477-0009 42.5 µM 2.4215592534711 0.00394427241882066 no 30 0.00772704068225862 170 3973534 SGTC_2547 epiafzelechin trimethyl ether 100 µM 2.39971866082883 0.00422607268309332 no 31 0.00820383851066261 53 6708630 An antioxidant. SGTC_2765 myclobutanil 7.74 µM 2.3935189803753 0.00430928008513897 no 32 0.00834380894377655 154 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2283 7944793 200 µM 2.392796412157 0.00431907251823881 no 33 0.00836025805629246 168 2970533 SGTC_341 1486-1430 230 µM 2.38348360038317 0.00444707422700768 no 34 0.00857482428709359 140 2054753 YPL210C SRP72 SGTC_2763 lisinopril 49.32 µM 2.37480807808955 0.00456935405492534 no 35 0.00877903848428303 80 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1239 0337-0584 35.4 µM 2.36177160857901 0.00475874720411117 no 36 0.00909392168131084 202 914301 YML130C ERO1 SGTC_916 4466-0038 42 nM 2.3039211376761 0.00568632241901443 no 37 0.010613535455009 245 5722064 YGL116W CDC20 SGTC_2466 5983409 37.09 µM 2.25635436147184 0.00656578512358509 no 38 0.0120242237087824 135 2879657 SGTC_546 peri-Naphthalide 147 µM 2.25603370521196 0.00657210079835199 no 39 0.0120342601785347 144 223824 A penicillin ester. SGTC_2027 5150920 200 µM 2.25574752521452 0.00657774196160498 no 40 0.0120432236825295 130 786715 SGTC_2918 7977171 22.06 µM 2.23415297163385 0.00701595882717555 no 41 0.0127365047942349 145 2236483 SGTC_3287 9117173 37.0625 µM 2.22773672866306 0.00715103571940346 no 42 0.0129490381288878 91 2789709 SGTC_117 lucigenin 22.078 µM 2.21097812233454 0.00751472200901572 no 43 0.0135186760470963 259 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.20235867763253 0.00770804626349799 no 44 0.0138199911808227 150 4213774 SGTC_1383 3049-0032 20.7 µM 2.19735946828614 0.00782216720303387 no 45 0.0139973917968898 172 712864 SGTC_1997 st073024 93.8 µM 2.18853654434412 0.00802720536898129 no 46 0.0143152711597819 136 686268 SGTC_333 3486-0131 40.1 µM 2.1694961721044 0.00848585605732095 no 47 0.0150225173309985 145 6744690 SGTC_1119 parthenolide 318.541 nM 2.14121049715172 0.00920965234122675 no 48 0.0161285334544637 254 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_130 0136-0219 337.655 µM 2.14062653367811 0.00922514786380258 no 49 0.0161520836449396 182 234244 SGTC_2791 5663188 71.43 µM 2.11624198757273 0.00989289627158877 no 50 0.0171621159333908 188 54690634 SGTC_1120 ficusin 1.78878 µM 2.09985933550212 0.0103648801900329 no 51 0.0178706084071254 189 6199 A DNA cross-linker. SGTC_3328 9140624 29.0385 µM 2.08181156235982 0.0109074490605647 no 52 0.0186798426094452 192 4904392 SGTC_2551 apiole 73.87 µM 2.08029990039142 0.0109539960820423 no 53 0.0187490169692741 108 10659 A possible DNA adduct former. SGTC_1678 st019265 80.2 µM 2.07944049661209 0.0109805357842105 no 54 0.0187884407977365 229 5367020 SGTC_839 0122-0028 230 µM 2.0787529616776 0.0110018081761998 no 55 0.0188200311753941 262 759448 SGTC_2955 9076254 12.21 µM 2.06633440346237 0.0113922579432997 no 56 0.0193984575375137 171 16459619 SGTC_1868 st057644 42.7 µM 2.06602174044721 0.0114022417608654 no 57 0.0194132134160657 234 688665 SGTC_1757 st041620 31.8375 µM 2.06530775604629 0.0114250689000802 no 58 0.0194469450882952 204 5289815 SGTC_2967 9089538 49.85 µM 2.05955911196461 0.0116103126705693 no 59 0.019720354242385 227 728216 SGTC_56 0957-0365 83.25 µM 2.04527147823378 0.0120820501152073 no 60 0.0204140504935995 238 6752360 SGTC_2545 solidagenone 89.61 µM 2.04387209022462 0.0121291352716749 no 61 0.0204830925008149 88 6708572 An anti ulcer agent SGTC_164 4100-3994 89.624 µM 2.03239490826524 0.0125213455793838 no 62 0.0210568465753511 267 4615967 SGTC_2713 st079149 53.4 µM 2.02171406737871 0.0128961590973065 no 63 0.0216029498690137 232 3103253 SGTC_945 3381-0768 11.3 µM 2.01754443412112 0.0130450922840507 no 64 0.0218193644457911 231 1126236 YIL048W NEO1 SGTC_608 k048-0125 159 µM 2.01639669643187 0.0130863478394056 no 65 0.0218792553450712 217 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1123 mangostin 811.285 nM 2.00512743880426 0.0134974478476484 no 66 0.0224747123918829 259 5281650 An antioxidant. SGTC_1492 4158-0558 28.5 µM 2.00385186000982 0.0135446756779113 no 67 0.0225429658161433 204 3967268 SGTC_41 0478-0632 82.643 µM 2.0028479852022 0.0135819440023158 no 68 0.0225968037729897 264 3750424 SGTC_2515 chrysin 20.77 µM 2.00082773453515 0.0136572130799554 no 69 0.0227054787369141 189 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM 1.97418190090402 0.0146841408461986 no 70 0.0241805316159518 137 88881 An O-methylated flavonoid and antioxidant. SGTC_192 3455-0609 60.9 µM 1.96991539304073 0.0148545941684583 no 71 0.024424033983621 208 3769639 SGTC_1608 st001473 40.5 µM 1.9670165002265 0.0149713776022145 no 72 0.0245906542779104 247 7292267 SGTC_1618 st003135 44.5 µM 1.96421976570878 0.0150847926681979 no 73 0.0247523057886137 197 1270615 SGTC_1977 st070720 65.3 µM 1.96281703603245 0.0151419546006769 no 74 0.0248337187777271 185 682188 SGTC_2920 7982904 15.77 µM 1.95914300552317 0.0152925560290083 no 75 0.0250480207950706 224 6456808 SGTC_910 3454-3003 490 µM 1.9535893180428 0.0155226474774377 no 76 0.0253749024578485 266 820824 SGTC_175 3793-3120 23.7 µM 1.93646338429877 0.0162509819887516 no 77 0.0264054864583304 228 5322297 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.92638482197306 0.0166931391472842 no 78 0.0270281706001625 192 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_770 0389-1121 67.2 µM 1.92474540720369 0.0167660266634454 no 79 0.0271306084092634 296 6753108 SGTC_1677 st019204 53.9 µM 1.91961138396416 0.0169960463152639 no 80 0.0274535025145731 243 3945625 SGTC_1204 4049-0315 18.3 µM 1.91251810694464 0.017318281236052 no 81 0.0279048862030829 262 588402 SGTC_1491 4138-0063 26.5 µM 1.898605060938 0.0179655007236338 no 82 0.0288082112515209 193 23883227 SGTC_766 1391-0721 126 µM 1.89253907811117 0.0182540757447449 no 83 0.029209596050006 250 1020919 YIL115C NUP159 SGTC_2595 hexamethylquercetagetin 100 µM 1.88829137281334 0.0184584936510194 no 84 0.0294934224335018 236 386331 SGTC_565 1418-0001 44.5 µM 1.86889244961106 0.0194170102879797 no 85 0.0308188894953892 302 2862145 SGTC_1764 st044502 93.5 µM 1.86787983209809 0.0194681849263582 no 86 0.0308894113066801 281 8407 SGTC_527 4476-4215 268 µM 1.8648244877106 0.0196232877145289 no 87 0.0311030048405937 282 4418754 SGTC_1081 sertraline 6 µM 1.85667779688621 0.0200419870972823 no 88 0.0316785041103878 307 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2063 5246145 200 µM 1.85388896470543 0.0201870495101239 no 89 0.0318775235010822 286 711240 SGTC_1534 6-azauridine 81.6 µM 1.84225151404098 0.0208020227321279 no 90 0.0327191842093716 310 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_349 k015-0014 24 µM 1.84132390935336 0.0208517167523117 no 91 0.0327870529954075 260 2196908 SGTC_3297 9117502 71.43 µM 1.84121275657591 0.0208576782120125 no 92 0.0327951933403835 210 7453720 SGTC_1148 3909-7663 27.7 µM 1.83236505607598 0.0213368576648023 no 93 0.033448525286309 266 4084526 SGTC_1728 st035614 33.7865 µM 1.81896776981114 0.0220801370861717 no 94 0.0344581736927965 357 15945546 SGTC_2520 obtusaquinone 4.71 µM 1.81795109389322 0.022137423560698 no 95 0.0345358039989358 247 5967872 SGTC_2692 st077426 47.7 µM 1.81190221774442 0.0224808578896991 no 96 0.0350006533394767 288 25238571 SGTC_1086 cerivastatin 2.18 µM 1.80889777067847 0.0226531032846052 no 97 0.035233443413886 227 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1991 st073000 8.92 µM 1.80818717979338 0.0226940038367251 no 98 0.0352886866234296 364 4301969 YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM 1.80594046302275 0.0228237312277287 no 99 0.0354638199118988 370 3125502 SGTC_2377 9073351 62.6 µM 1.79429374563584 0.0235062793294705 no 100 0.0363831479268374 300 7337946 YHR072W ERG7 SGTC_1101 ebselen 5.29 µM 1.78189591019784 0.0242516330347854 no 101 0.0373831038058904 298 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1338 1486-1223 76 µM 1.77585732589568 0.0246217987489045 no 102 0.0378782180937869 298 3444526 SGTC_940 3232-1287 54.8 µM 1.77572008979731 0.0246302661266378 no 103 0.0378895322136305 290 1585493 YIL048W NEO1 SGTC_1750 st081859 2.357 µM 1.77347855780182 0.0247689134177651 no 104 0.0380747209264322 525 5291695 SGTC_559 1550-0661 158 µM 1.77187097487869 0.0248687511681568 no 105 0.0382079887512457 282 5830875 SGTC_2707 st078556 66.6 µM 1.76813617854666 0.025102001322105 no 106 0.0385190702532437 261 17250899 SGTC_2402 5553605 200 µM 1.76528121587258 0.0252815371944215 no 107 0.0387582574331526 319 6758546 SGTC_2518 prenyletin 46.28 µM 1.76323633754739 0.0254107906999019 no 108 0.0389303187466817 194 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2555 cholic acid 100 µM 1.76320910841675 0.0254125155371833 no 109 0.0389326140652901 274 6708657 Influences liver metabolism. SGTC_2560 caryophyllene 100 µM 1.75753835607267 0.0257738740540495 no 110 0.0394130450169147 330 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_334 1502-1024 68.5 µM 1.74853234893631 0.0263565985083695 no 111 0.0401859445674746 311 3296216 SGTC_2757 clomiphene 4.22 µM 1.73758230613097 0.0270799037402919 no 112 0.0411422198945382 357 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3177 9107506 49.47 µM 1.73124088566338 0.0275063089437583 no 113 0.0417044049694617 235 8897194 SGTC_3183 9108214 49.47 µM 1.73098347076503 0.0275237354106645 no 114 0.0417273563011201 161 4974831 SGTC_716 1683-5115 658 µM 1.72869544539 0.0276790349541585 no 115 0.0419318084728264 361 723597 SGTC_1632 st005650 90 µM 1.72486194102705 0.0279408702684924 no 116 0.0422761778987556 313 2759605 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.72465492235548 0.0279550685355933 no 117 0.042294839623785 266 17037758 SGTC_199 4063-0024 41.6 µM 1.72127845593208 0.0281874912623142 no 118 0.0426001534850257 274 306215 SGTC_2020 4017018 200 µM 1.7210530651253 0.0282030633911253 no 119 0.0426205975270781 318 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_727 3032-0951 202 µM 1.71839103184353 0.0283875242074461 no 120 0.0428626575161497 305 3652836 SGTC_1671 st016596 74.5 µM 1.71787555172421 0.0284233592491694 no 121 0.0429096585322741 338 2829167 SGTC_2057 5236571 38.335 µM 1.71148615555134 0.0288706690116664 no 122 0.0434957023724284 374 54684039 YBR257W POP4 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.71079727995073 0.0289192434751581 no 123 0.0435592709458657 320 165521 SGTC_2085 5307070 144.047 µM 1.70847896481121 0.0290832133034303 no 124 0.043773753115682 278 2840351 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.70513712505693 0.0293209336711821 no 125 0.0440844265359657 331 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3265 9137266 49.47 µM 1.70164225817055 0.0295712634596153 no 126 0.0444112253653252 257 17224265 SGTC_1040 k898-0338 155 µM 1.70037317185053 0.0296626033040877 no 127 0.0445303774212198 358 20969351 SGTC_2407 paclitaxel 400 µM 1.70023093860026 0.0296728548206428 no 128 0.0445437474593954 375 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_519 k048-0011 62.8 µM 1.6987870060633 0.0297770933366356 no 129 0.0446796613946117 324 6836379 SGTC_544 k015-0020 52.4 µM 1.69425024729944 0.0301065837378021 no 130 0.0451088701713296 305 3008304 SGTC_265 mycophenolic acid 32.932 µM 1.69384440957324 0.0301362051666772 no 131 0.0451474263627507 347 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_862 0452-0056 10.2 µM 1.68533077284779 0.0307631919527789 no 132 0.0459623858731516 298 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1013 4112-3890 241 µM 1.68239926223154 0.0309815671137418 no 133 0.0462457221821747 348 705171 SGTC_2650 prasterone 100 µM 1.68179022010933 0.0310270966693703 no 134 0.0463047629135165 199 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_6 0844-0013 19.835 µM 1.68070839695253 0.0311081059533313 no 135 0.0464097843978743 596 1584900 SGTC_593 1203-0218 61.7 µM 1.67940565435965 0.0312058903206314 no 136 0.0465365060288855 321 3666956 SGTC_1815 st051655 58.2 µM 1.67349785165555 0.0316525282673083 no 137 0.0471146645609619 278 5984156 SGTC_2899 9053889 58.44 µM 1.66842085820814 0.0320405643411507 no 138 0.0476161052498013 277 6470052 SGTC_80 0159-0065 512.242 µM 1.66621499114432 0.0322103792012257 no 139 0.0478353005761633 206 1548079 SGTC_3314 9135860 59.4275 µM 1.66264263660528 0.0324869660197881 no 140 0.0481919955359108 326 25252478 SGTC_3009 9080819 71.4286 µM 1.65680812421195 0.0329429098792333 no 141 0.0487791369859104 320 17027216 SGTC_1605 st000082 49.1 µM 1.65520149674461 0.0330693833949467 no 142 0.048941815867838 315 1114022 SGTC_167 3672-0051 66.205 µM 1.65134015841647 0.033374984289306 no 143 0.0493345682916252 333 3237971 SGTC_1726 st035556 14.5795 µM 1.65108176913537 0.0333955169341887 no 144 0.0493609396876121 379 5919439 SGTC_899 1083-0020 478 µM 1.64260260966064 0.0340750968832186 no 145 0.0502325902414344 377 767123 SGTC_3349 9149703 23.001 µM 1.64238662527903 0.0340925548256522 no 146 0.050254952469391 320 4910494 SGTC_3284 9108171 64.8615 µM 1.64115981980064 0.034191856660177 no 147 0.0503821219657714 302 8687505 SGTC_211 3455-0679 143.504 µM 1.63570684836883 0.0346361200863212 no 148 0.0509504777563991 384 748649 SGTC_1661 st013063 9.66 µM 1.62996515632047 0.0351090191164433 no 149 0.0515544306945941 385 721395 SGTC_580 1123-0028 41 µM 1.62686427523776 0.0353666100980356 no 150 0.0518829634206269 422 1677248 YPR107C YTH1 SGTC_2292 7671323 168.05 µM 1.62002266001496 0.0359404291285939 no 151 0.0526137046756544 381 937504 SGTC_1422 4031-0024 15.5 µM 1.6188155787002 0.0360424564919642 no 152 0.0527434745924233 345 782427 SGTC_24 0417-1663 219 µM 1.60931963558509 0.0368533911024397 no 153 0.0537732338501321 355 4329390 SGTC_866 0495-0101 262 µM 1.60417446622241 0.0372989727485289 no 154 0.0543378006630257 322 635694 SGTC_2506 ethyl hematommate 54.16 µM 1.60262048904365 0.0374344123084662 no 155 0.054509233699854 307 3940691 An allergen. SGTC_2525 harmine 47.85 µM 1.60099941389768 0.0375761276987734 no 156 0.0546885244797256 283 5280953 A monoamine oxidase inhibitor SGTC_1739 st037196 92.5 µM 1.6009828493064 0.0375775780433397 no 157 0.0546903589257225 377 612214 SGTC_3271 9137798 49.47 µM 1.59983773805959 0.0376779513056783 no 158 0.0548172922658903 281 6498326 SGTC_973 1325-0077 65.9 µM 1.59680348953454 0.037944973137828 no 159 0.0551547589328294 398 2835149 SGTC_3342 9147791 14.508 µM 1.59391470221246 0.0382006267895607 no 160 0.0554775704978596 360 1838168 SGTC_1919 st067113 52.3 µM 1.59290037986788 0.0382907254156693 no 161 0.0555912705392217 398 1268243 SGTC_3262 9137218 49.47 µM 1.59286801184306 0.0382936034018506 no 162 0.0555949018456577 200 17650664 SGTC_2123 5259487 200 µM 1.59202525867069 0.0383685984622182 no 163 0.0556895146186108 375 2173474 SGTC_3004 9076122 71.4286 µM 1.59195205177659 0.0383751186578245 no 164 0.0556977392799909 382 44782551 SGTC_2052 5265182 7.135 µM 1.59128054766168 0.0384349685401877 no 165 0.0557732262770261 384 1239884 SGTC_1270 0831-1170 17.3 µM 1.58796905902341 0.0387312289193953 no 166 0.056146667925614 402 6764716 SGTC_1151 3909-8316 15.3 µM 1.58614235470596 0.0388954484495518 no 167 0.0563535103921714 384 800431 SGTC_1668 st014914 51.6 µM 1.58598991663867 0.0389091781285389 no 168 0.056370798467429 331 2839556 SGTC_1693 xanthone 101.9 µM 1.58322226546369 0.0391591399315967 no 169 0.0566854066517649 385 7020 An insecticide. SGTC_446 go6976 132 µM 1.5733689008273 0.0400596810328248 no 170 0.0578167118500184 338 3501 A protein kinase C inhibitor. SGTC_1054 3429-0080 167 µM 1.57262998799735 0.0401278862096729 no 171 0.0579022598679475 417 1162877 SGTC_1636 st007707 68.9 µM 1.56658566847859 0.0406893547273949 no 172 0.0586057849400788 437 403051 SGTC_3142 9086498 49.47 µM 1.56079726323052 0.0412330108892703 no 173 0.0592857966949634 372 25236367 SGTC_2262 9014885 67.46 µM 1.55901511784533 0.0414015734744459 no 174 0.0594964010302588 272 6457424 SGTC_2156 5649887 115 µM 1.55805248887245 0.0414928548898075 no 175 0.0596104030048072 435 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2094 5332512 191.667 µM 1.55658564854918 0.041632261713933 no 176 0.0597844466635655 389 755774 SGTC_1909 st060837 51.5 µM 1.54910852726964 0.0423487859532022 no 177 0.0606778166882901 424 678937 SGTC_650 1328-0195 38 µM 1.54895803794647 0.042363308950428 no 178 0.0606959038348663 405 2780821 SGTC_344 k064-0035 6.43 µM 1.54405505276709 0.0428386803863529 no 179 0.0612874981563511 395 5088750 SGTC_3347 9188721 44.724 µM 1.53974131823616 0.0432604773366125 no 180 0.0618117104883494 355 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2625 euphol 100 µM 1.53486941143223 0.0437408784951239 no 181 0.0624079542640031 453 6708538 A triterpene alcohol. SGTC_1079 idarubicin 2.36 µM 1.53352707828278 0.0438739947672376 no 182 0.0625730200300123 361 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1913 st060213 96.1 µM 1.52030167805456 0.0452030714666879 no 183 0.0642175862469171 449 688959 SGTC_2780 5215298 71.43 µM 1.51966814879756 0.0452675417845492 no 184 0.0642972002982841 433 2834131 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.51711822203372 0.0455277803208058 no 185 0.0646184191928948 418 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3027 9089541 49.47 µM 1.51702198189211 0.0455376258353449 no 186 0.0646305671031952 437 9943819 SGTC_1009 4106-0057 9.87 µM 1.51166991176058 0.0460878511397046 no 187 0.0653089283052673 429 2928005 SGTC_1785 bathophenanthroline 24 µM 1.50636507284444 0.046638477932765 no 188 0.06598674084139 449 72812 An iron chelator. SGTC_942 3253-1115 227 µM 1.49756987851449 0.0475630127284532 no 189 0.0671225187965488 420 46497897 SGTC_1039 k821-0043 94 µM 1.48737087876449 0.0486534333997697 no 190 0.0684584419091071 431 15992768 SGTC_2586 curcumin 80 µM 1.48710693409941 0.0486819159895321 no 191 0.0684932852195915 508 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1646 st011709 75.6 µM 1.4858024648489 0.0488228786241055 no 192 0.0686656890020851 370 5757843 SGTC_3204 9114183 49.47 µM 1.47915854953498 0.0495458973878122 no 193 0.0695489724609241 420 17027248 SGTC_2114 5491910 81.25 µM 1.47618619124489 0.0498721165723313 no 194 0.0699469577486747 430 2849228 SGTC_1377 2944-0135 198 µM 1.47408020712016 0.0501042855709161 no 195 0.0702299984932394 469 1894137 SGTC_1607 st000305 50.6 µM 1.46994101799307 0.0505631108943719 no 196 0.0707888645669983 451 5457690 SGTC_2843 9000894 45.46 µM 1.46389747340203 0.0512390363972377 no 197 0.0716109819237672 297 2242070 SGTC_2995 9067767 71.4286 µM 1.46119146408556 0.0515440042951439 no 198 0.071981452455248 382 11673567 SGTC_1306 1185-0270 9.02 µM 1.45930526854345 0.0517574313486726 no 199 0.0722405529838393 488 1548076 SGTC_1875 nocodazole 6 µM 1.45795657976903 0.0519104686142844 no 200 0.0724262557913989 436 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_584 0986-0246 15.4 µM 1.45656412044529 0.0520688496180155 no 201 0.0726183689284557 485 53315 YDR232W HEM1 SGTC_1084 voriconazole 435 nM 1.45150537751144 0.0526474735760573 no 202 0.0733195929629003 436 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1161 k007-0610 110 µM 1.45028167446462 0.0527882055776484 no 203 0.073489993599227 569 5843850 SGTC_1424 4048-1941 275 µM 1.44242913519644 0.0536984024083645 no 204 0.0745906747838323 464 X1424 SGTC_987 1497-1013 404 µM 1.44241080477118 0.0537005415592277 no 205 0.0745932587772632 393 1676435 SGTC_1615 st002656 86.5 µM 1.44215184331929 0.0537307694354418 no 206 0.0746297712155391 435 1584458 SGTC_529 4076-0302 30.3 µM 1.43965198003111 0.0540232651902304 no 207 0.0749829427640907 458 5816522 SGTC_1346 1488-2224 62.4 µM 1.43880433877103 0.0541227288527535 no 208 0.0751029833804755 454 3722427 SGTC_696 1560-0013 611 µM 1.43815746163798 0.0541987319739877 no 209 0.0751946908845912 468 1650269 SGTC_859 0439-0102 54.6 µM 1.43650452259374 0.0543933233379443 no 210 0.0754294151810866 489 610143 SGTC_2324 6149169 200 µM 1.43336495482246 0.0547644486889197 no 211 0.0758767840509508 416 2888231 SGTC_1500 4488-1866 171 µM 1.42883612026452 0.0553033209874935 no 212 0.076525670605848 509 2900003 SGTC_2376 9072922 81.32 µM 1.4286713364401 0.0553230067885268 no 213 0.0765493599970589 501 17087968 SGTC_1685 st024049 53.0905 µM 1.42609379811834 0.0556316516688552 no 214 0.0769206343707012 409 1941139 SGTC_415 dibenzyl ketone 100 µM 1.41738892935855 0.0566840625670004 no 215 0.078184623803379 461 7593 SGTC_1138 3761-0006 1.03 µM 1.41283307948397 0.0572410792820062 no 216 0.0788524047057516 431 12061087 SGTC_2084 5306078 60.6385 µM 1.41247377380011 0.0572851920776562 no 217 0.0789052537767185 468 679340 SGTC_185 k048-0037 25.491 µM 1.41226324218069 0.0573110519620914 no 218 0.0789362326331227 483 6827589 SGTC_2248 tofa 1.1 µM 1.41109184554209 0.0574551039834985 no 219 0.079108767061911 431 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3308 9128332 17.569 µM 1.40025019397124 0.0588019062041035 no 220 0.0807192048849096 579 17332805 YDL196W YDL196W SGTC_740 k014-0057 261 µM 1.4001800138141 0.0588107043411044 no 221 0.080729709617807 540 4012779 SGTC_3261 9137475 49.47 µM 1.40000069009408 0.0588331899557434 no 222 0.0807565559077839 269 17027690 SGTC_1705 st027868 56.3335 µM 1.39210022509612 0.0598305513479299 no 223 0.0819460250551251 452 292948 SGTC_1489 4065-0444 182 µM 1.38785518667076 0.0603718922725234 no 224 0.0825905730614788 472 2877968 SGTC_2583 asiatic acid 100 µM 1.38666164448822 0.0605247849413372 no 225 0.0827724807503834 456 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2711 st079103 59.1 µM 1.38214233548905 0.0611064547358402 no 226 0.0834640008357091 451 54693780 SGTC_2257 7960413 200 µM 1.37700008312246 0.0617736059587816 no 227 0.084256111070326 561 2974689 YIL048W NEO1 SGTC_2690 usnic acid 100 µM 1.36147918217466 0.0638217862260387 no 228 0.0866811539960293 577 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1456 k015-0012 13 µM 1.3606834810083 0.0639281956978981 no 229 0.0868068685622733 578 2989616 SGTC_946 3434-1334 87.4 µM 1.36008324504591 0.0640085567753993 no 230 0.0869017912627236 501 4047976 SGTC_1725 st036284 20.55 µM 1.36004057502122 0.0640142725330307 no 231 0.0869085421499911 554 707914 SGTC_1740 st038286 13.222 µM 1.35800904650165 0.0642868604169256 no 232 0.0872304068105315 509 716786 SGTC_2365 9042475 200 µM 1.35707669730989 0.0644122634506028 no 233 0.0873784209174999 526 6464479 SGTC_537 1334-0398 209 µM 1.35508138266704 0.0646812762699568 no 234 0.0876958147755924 523 5846986 SGTC_1280 0880-0253 10.1 µM 1.35460045842294 0.0647462458782497 no 235 0.0877724436744975 523 6836607 SGTC_2919 7978188 46.38 µM 1.35318761292543 0.0649374048732981 no 236 0.0879978507606607 525 2980291 SGTC_2965 9082772 38.63 µM 1.35256862154971 0.0650212927411956 no 237 0.0880967412648732 552 16459634 SGTC_2139 5578692 56.4705 µM 1.35128097981165 0.065196067888366 no 238 0.08830272122949 444 650991 YMR113W FOL3 SGTC_245 methotrexate 289.6 µM 1.35029982317395 0.0653294875034052 no 239 0.0884599145303617 551 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_668 1682-0499 62.6 µM 1.34794861723514 0.0656500710150825 no 240 0.0888374547918298 582 682214 SGTC_3086 9117350 49.47 µM 1.3463455489784 0.0658693453951322 no 241 0.0890955513198629 393 2679265 SGTC_2452 5863136 48.41 µM 1.3442613285821 0.0661552819750519 no 242 0.0894319480123076 505 2184096 SGTC_725 1497-0963 19 µM 1.33665844129469 0.0672064869705321 no 243 0.090667076638937 532 3549977 SGTC_826 1683-5028 118 µM 1.33488876149282 0.0674530129339985 no 244 0.0909563782897951 503 722377 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.33292446726391 0.0677274675035816 no 245 0.0912782961604357 401 1241132 A phosphatase inhibitor. SGTC_1457 k015-0032 57.3 µM 1.33283038962347 0.0677406338080935 no 246 0.0912937352218093 524 4302660 SGTC_3157 9099274 49.47 µM 1.32844901188178 0.0683560069226635 no 247 0.0920149086042736 497 17217662 SGTC_54 0159-0055 9 µM 1.32783929798316 0.068441983258145 no 248 0.092115600755945 521 3319099 SGTC_751 0833-0568 350 µM 1.32705239081688 0.0685530690768346 no 249 0.0922456763187618 530 6954252 SGTC_409 arachidonic acid 100 µM 1.32623888647881 0.0686680557070351 no 250 0.0923802912607994 532 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1296 1068-0102 11.9 µM 1.32020234216045 0.0695259570166957 no 251 0.0933837351025804 533 767053 SGTC_183 3914-0051 30.55 µM 1.31864013977198 0.0697493127802196 no 252 0.0936447238331935 526 1596232 SGTC_1828 st055811 49 µM 1.31790648673984 0.0698543971773687 no 253 0.0937674769831279 468 5877589 SGTC_564 3555-0129 330 µM 1.31749070310521 0.0699140057915458 no 254 0.0938370976662469 428 563260 SGTC_1686 st019653 115.5 µM 1.31626286802101 0.0700902622296328 no 255 0.0940429145957983 508 97252 SGTC_89 0302-0250 142.109 µM 1.31220572688964 0.0706750985937457 no 256 0.0947253650439452 582 4203518 YLR208W SEC13 SGTC_864 0469-0573 172 µM 1.30794457782396 0.0712933728714091 no 257 0.0954460540396567 528 689425 SGTC_2473 5854593 8.94 µM 1.30793041628191 0.0712954345500263 no 258 0.0954484558942893 503 2872951 SGTC_3152 9099253 49.47 µM 1.30307594863372 0.072004862583664 no 259 0.0962744169325087 648 25236131 SGTC_1616 st002734 56.1 µM 1.30073735381159 0.0723485488463343 no 260 0.0966741858546484 564 4026101 SGTC_886 0866-0150 153 µM 1.29450842977183 0.0732701009708744 no 261 0.0977449297103975 574 271463 SGTC_38 0929-0051 58.268 µM 1.29277134031995 0.0735286931811899 no 262 0.0980450777259667 597 1379719 SGTC_2769 toremifene 3.73 µM 1.29222734807283 0.0736098180375673 no 263 0.0981392117159656 516 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_634 1611-4317 11.2 µM 1.29100223360838 0.0737927683423008 no 264 0.0983514514981611 596 2843522 SGTC_133 0724-0033 378.92 µM 1.28786178629435 0.0742633286501738 no 265 0.0988970398791183 522 280309 SGTC_2298 7976326 193.81 µM 1.28231047176892 0.0751007307591529 no 266 0.0998668779825508 480 2235818 SGTC_312 4092-0653 6.84 µM 1.27990593365181 0.0754656765483721 no 267 0.100289110275893 655 1148278 SGTC_3330 9141424 71.43 µM 1.27944203437318 0.075536239548737 no 268 0.100370719816683 601 27261020 SGTC_2891 9063876 19.48 µM 1.26524808100748 0.0777196443483697 no 269 0.102891205825144 494 6472478 SGTC_2628 lathosterol 100 µM 1.26495998143412 0.0777644525750074 no 270 0.102942836890091 579 6710616 SGTC_1571 st070080 73.4 µM 1.2636915738792 0.077961961676583 no 271 0.103170375325232 566 4315245 SGTC_3292 9120825 59.784 µM 1.26214113241163 0.0782039041885509 no 272 0.103449003352316 585 24824900 SGTC_3244 9134489 49.47 µM 1.26178046179114 0.0782602674959352 no 273 0.103513897281388 567 16584271 SGTC_1703 st026983 48.3 µM 1.2583440723244 0.0787988305751874 no 274 0.104133674397409 607 1104023 SGTC_73 0327-0325 16.231 µM 1.25700304291086 0.0790097615166768 no 275 0.104376266862899 660 53298 SGTC_1694 st024011 44.9 µM 1.25476495830982 0.0793627425724109 no 276 0.104782048415089 626 2787533 SGTC_791 1348-1292 225 µM 1.25355579991059 0.079553941808317 no 277 0.105001752644971 672 5437054 SGTC_57 miconazole 162.5 nM 1.24786003036692 0.0804592808082367 no 278 0.106041160103126 557 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_702 1488-0190 94 µM 1.24623271824705 0.0807193652829966 no 279 0.106339485290604 586 949357 SGTC_1804 st050076 49.1 µM 1.24268111063751 0.0812892036122698 no 280 0.106992683667952 596 3895976 SGTC_822 1487-0950 154 µM 1.24154538102161 0.0814720648729487 no 281 0.107202172283122 580 1958375 SGTC_390 dec-rvkr-cmk 16.7 µM 1.24081178923557 0.0815903436277198 no 282 0.107337642533651 617 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_253 dyclonine 31.25 µM 1.2400680271649 0.0817103942931872 no 283 0.10747511684629 636 3180 An oral anasthetic. SGTC_1698 5-fluorocytosine 1.055 µM 1.23318862362405 0.0828271180596865 no 284 0.10875269939244 581 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1981 st071826 47 µM 1.23306060374608 0.0828480076369178 no 285 0.10877657718533 543 11838600 SGTC_2787 5284540 71.43 µM 1.23251511059394 0.0829370626296302 no 286 0.10887836279901 575 736958 SGTC_2008 4012253 172 µM 1.23162558577389 0.0830824372588257 no 287 0.109044489411343 609 603940 SGTC_683 panaxydol 45 µM 1.23037410061752 0.0832872912564951 no 288 0.109278523654652 629 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3235 9132602 49.47 µM 1.22928100976807 0.0834665283726312 no 289 0.109483232394703 632 4912240 SGTC_2803 7707263 71.43 µM 1.22365536164703 0.0843935689639036 no 290 0.11054113279499 565 2199229 SGTC_1158 4092-0494 91.8 µM 1.22101701381975 0.0848309897415591 no 291 0.111039789009487 631 1148199 SGTC_2034 5197015 53.07 µM 1.21375369192737 0.0860439803577752 no 292 0.112420897268057 614 780676 SGTC_941 3237-0776 460 µM 1.20909386391978 0.0868289867344347 no 293 0.113313393171036 579 760008 SGTC_2839 9003951 25.97 µM 1.20871230161028 0.0868935019386301 no 294 0.113386696960303 574 2990634 SGTC_2286 7945697 125 µM 1.20857890634193 0.0869160650840236 no 295 0.113412332150699 612 1245733 SGTC_807 1315-0151 48 µM 1.20194044753509 0.0880444637922604 no 296 0.114693300971227 703 4011080 SGTC_3251 9135047 49.47 µM 1.19897526492829 0.0885519972207894 no 297 0.115268781844758 553 17682963 SGTC_251 melphalan 456.522 µM 1.19609740619924 0.0890466649595922 no 298 0.115829274858913 707 460612 A DNA alkylator. SGTC_2441 5730946 39.09 µM 1.19319652753618 0.0895473680620573 no 299 0.116396207153217 633 1774275 SGTC_718 1130-0073 349 µM 1.1931513230306 0.0895551870715049 no 300 0.116405057230767 651 6740020 SGTC_2886 9058944 51.95 µM 1.19096590610964 0.0899338038255917 no 301 0.116833484752732 452 4949929 SGTC_2078 5212016 200 µM 1.19081361733443 0.0899602316551538 no 302 0.116863380935638 581 1899708 SGTC_506 n9-isopropylolomoucine 153 µM 1.19024280295814 0.0900593407724199 no 303 0.116975487157843 619 6610355 SGTC_118 0083-0097 135.343 µM 1.18725636151051 0.0905791922170364 no 304 0.11756325770275 841 5207356 SGTC_872 0588-0139 234 µM 1.1860868154511 0.0907833815706742 no 305 0.117794008361846 642 2047100 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.18496749091841 0.0909791225135195 no 306 0.118015150324233 611 756377 SGTC_676 falcarinol 140 µM 1.18312713862585 0.0913016328447152 no 307 0.118379381876262 654 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2977 9011197 71.43 µM 1.18043440903146 0.0917750432689378 no 308 0.11891374166039 564 2704722 SGTC_1351 1496-0003 46.5 µM 1.18028903706668 0.0918006528403497 no 309 0.118942638444158 648 3891978 SGTC_3007 9078383 71.4286 µM 1.17860187681965 0.0920982601329385 no 310 0.119278371976766 649 6496995 SGTC_2999 9069765 71.4286 µM 1.17829534817948 0.0921524069648479 no 311 0.119339440837734 666 2097066 SGTC_2341 7987486 176.74 µM 1.17732105995266 0.0923246668570577 no 312 0.119533692117982 664 1258686 SGTC_1247 0448-0043 5.84 µM 1.17365021280664 0.0929758347805754 no 313 0.120267579939243 679 3089013 YGL099W LSG1 SGTC_1129 3453-1384 223 µM 1.1712855120844 0.0933971008859614 no 314 0.120742016474473 686 1084452 SGTC_298 1391-0729 10 µM 1.16841434274455 0.0939104864651447 no 315 0.121319836143281 613 3237558 SGTC_53 0973-0023 39.979 µM 1.1682217848889 0.0939449915616585 no 316 0.121358657657209 622 674768 SGTC_2384 9036245 200 µM 1.1658815226368 0.0943650992126311 no 317 0.121831175280285 661 6462766 SGTC_542 3381-0244 89.3 µM 1.16496908726613 0.094529268114237 no 318 0.122015753008296 721 1112843 SGTC_1430 4049-0248 69.1 µM 1.16199982297156 0.0950649670792514 no 319 0.122617768420663 717 22774488 SGTC_1340 1486-1359 257 µM 1.1613217328932 0.0951876175281561 no 320 0.122755542292329 662 4309068 SGTC_337 1315-0038 354 µM 1.15890937152357 0.09562490129816 no 321 0.123246564262038 658 1626437 SGTC_3315 9136395 68.55 µM 1.15326535870477 0.096653751276917 no 322 0.124400742052567 709 16876844 SGTC_1625 st003711 30.1 µM 1.15106442336136 0.0970571567643891 no 323 0.124852866410389 656 24207034 YER133W GLC7 SGTC_1025 k007-0731 70 µM 1.15099454626459 0.097069984622431 no 324 0.124867239604732 635 6256118 SGTC_1175 0741-0056 27.6 µM 1.14944445809004 0.0973548658923476 no 325 0.125186378412638 730 765927 SGTC_1043 0916-0009 19.3 µM 1.14824710424951 0.0975753397862451 no 326 0.125433284348949 779 3101130 SGTC_1088 bifonazole 369 nM 1.14740361262081 0.0977308751914648 no 327 0.125607424410512 665 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2685 mycophenolic acid 18.85 µM 1.1461853498436 0.0979558371454541 no 328 0.125859234166294 624 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1426 4048-4480 71.7 µM 1.14484092657835 0.0982045358547146 no 329 0.126137529170261 670 14224343 SGTC_518 1021-0119 62.6 µM 1.14114618907185 0.0988903900776714 no 330 0.126904546423186 645 1097762 SGTC_1066 ketoconazole 628 nM 1.14110257519915 0.0988985069978466 no 331 0.126913619889095 720 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_983 1491-0821 12.2 µM 1.13991953913581 0.0991188662471715 no 332 0.127159911956296 660 46495113 SGTC_3312 9133330 71.43 µM 1.13769258809835 0.0995346450225652 no 333 0.127624434729321 722 17617324 SGTC_2212 7123476 200 µM 1.1376567750983 0.0995413418205668 no 334 0.127631914638003 567 1085715 SGTC_1901 st060216 58.6 µM 1.13634875975442 0.0997861578675188 no 335 0.127905315780697 683 688792 SGTC_884 0851-0618 334 µM 1.13615559579756 0.0998223488413852 no 336 0.127945725337323 701 9642473 SGTC_474 dl-dihydrosphingosine 5 µM 1.13564344892502 0.0999183504917647 no 337 0.128052908487151 679 3058739 A sphingolipid protein kinase C inhibitor. SGTC_803 4488-1585 147 µM 1.13495320762839 0.10004784249959 no 338 0.128197462259768 667 747204 SGTC_234 nsc-17383 10.7 µM 1.13483774486133 0.100069515731079 no 339 0.128221654107619 740 408974 SGTC_2983 9022671 12.99 µM 1.13362452880928 0.100297452804944 no 340 0.128476039740507 645 6405161 SGTC_347 4534-1311 26.2 µM 1.13248755144032 0.100511410027104 no 341 0.128714757534607 678 2862016 SGTC_2382 9035899 200 µM 1.13239057873819 0.100529673820239 no 342 0.128735131988712 690 6462679 SGTC_2129 girgensonine 121.053 µM 1.1314643962801 0.100704232594339 no 343 0.128929840341559 722 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1667 st014849 34.6 µM 1.12852244585796 0.101260171853055 no 344 0.129549671459231 712 5348460 SGTC_1672 st016598 6.51 µM 1.12634277872658 0.101673502525079 no 345 0.130010228550602 674 4665860 YNL267W PIK1 SGTC_904 1141-0088 396 µM 1.12625084377704 0.101690963125677 no 346 0.130029679005738 660 1378119 SGTC_425 3825-7017 13.1 µM 1.12618278943587 0.101703889645435 no 347 0.130044078395511 720 3397440 SGTC_3230 9131665 49.47 µM 1.12594803814102 0.101748488446726 no 348 0.130093757104129 551 15943720 SGTC_799 1310-0557 151 µM 1.12568815671674 0.10179787815404 no 349 0.13014876923597 677 5354492 SGTC_2014 4013930 200 µM 1.121377746572 0.10261960568956 no 350 0.131063552221554 762 64556 SGTC_620 0109-0052 432 µM 1.12112498498208 0.102667940853819 no 351 0.131117332448299 708 493037 SGTC_1339 1486-1321 22.7 µM 1.11961727186159 0.102956602008173 no 352 0.131438446079041 682 3469382 SGTC_193 1273-0060 1.558 µM 1.11845917513281 0.103178726947028 no 353 0.131685466594967 590 2847393 YHR072W ERG7 SGTC_2926 9010726 65.15 µM 1.11776515722784 0.103312007425104 no 354 0.131833653125787 665 2994293 SGTC_1382 3002-2117 298 µM 1.11418033463949 0.104002433881706 no 355 0.132600915083055 749 1497314 SGTC_1263 0774-1208 64.8 µM 1.11231524252183 0.104362965629789 no 356 0.133001316227545 778 906585 SGTC_2348 9022543 33.42 µM 1.11164730547928 0.104492301246229 no 357 0.133144912287088 714 3162678 YDL140C RPO21 SGTC_856 0433-0016 11.3 µM 1.11134350943774 0.104551165028216 no 358 0.133210258991408 722 3911780 SGTC_2237 6667747 47.222 µM 1.1093780928932 0.104932566320406 no 359 0.133633554456265 664 729940 YDL015C TSC13 SGTC_2119 5528445 120.635 µM 1.10516381337748 0.105753766700728 no 360 0.134544306859538 700 791935 SGTC_1130 3454-2858 15.9 µM 1.1024529582881 0.106284457234404 no 361 0.13513239947959 682 715628 YIL048W NEO1 SGTC_1257 0669-0121 16 µM 1.1013963974525 0.106491814905508 no 362 0.135362086338097 764 4307855 SGTC_1116 jasmonic acid  1.58368 µM 1.10090797659927 0.106587769667992 no 363 0.135468355042929 721 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1332 1480-0653 17.5 µM 1.09841679816607 0.107078155582552 no 364 0.136011265271657 687 5749438 SGTC_2463 5473429 200 µM 1.09567513023202 0.107619728599708 no 365 0.136610484999912 685 5399405 SGTC_275 trichlorophene 5.69 µM 1.08821643587886 0.109103056672346 no 366 0.138249785284898 847 62616 SGTC_2380 9035439 200 µM 1.08346048635543 0.110056522068446 no 367 0.139302040220572 772 6462575 SGTC_964 1287-0107 19.4 µM 1.07994068970436 0.11076600456964 no 368 0.140084296156552 772 51516812 YPR165W RHO1 SGTC_3269 9137823 49.47 µM 1.07605290818862 0.111553463832893 no 369 0.140951797438082 646 17682936 SGTC_2430 5571206 200 µM 1.07541252162767 0.111683555639756 no 370 0.141095039082902 816 1731771 SGTC_3039 9090270 49.47 µM 1.07102905758247 0.112576952309233 no 371 0.142078182223287 687 17173750 SGTC_1451 4152-0210 104 µM 1.06973623888726 0.112841414625064 no 372 0.142369024791714 755 659563 SGTC_1336 1486-0901 104 µM 1.0654661910094 0.113718057492042 no 373 0.143332508630893 734 5006114 SGTC_1654 st012436 41.8 µM 1.06487181765391 0.113840466472237 no 374 0.143466969958604 691 4323132 SGTC_988 1497-1057 103 µM 1.0633403128823 0.114156306792152 no 375 0.143813824902202 771 3533044 SGTC_1989 st071868 50.2 µM 1.06331927923767 0.114160648874812 no 376 0.143818592533604 767 16414057 SGTC_935 2996-0153 430 µM 1.06044237495173 0.114755651678663 no 377 0.144471696388673 751 23738523 SGTC_2847 9005661 71.43 µM 1.0595900947066 0.11493234360972 no 378 0.144665560927255 629 2991449 SGTC_2973 9094665 17.96 µM 1.05910210105649 0.115033599918747 no 379 0.144776641607257 818 25237061 YIL048W NEO1 SGTC_1765 st044815 90.4 µM 1.05813714723155 0.115234009854766 no 380 0.144996460494513 717 645695 SGTC_2401 5128683 200 µM 1.05196618674842 0.116521518244537 no 381 0.1464075316941 682 708373 SGTC_1579 chlormadinone acetate 49.4 µM 1.04844795271523 0.117260112482754 no 382 0.147216135062414 783 45114258 A steroidal progestin. SGTC_182 3448-4371 550.524 µM 1.04538236503975 0.117906379689359 no 383 0.147923141942308 811 3491403 SGTC_1958 st076513 41.9 µM 1.04492998690953 0.118001960057185 no 384 0.148027664629785 747 732122 YGL099W LSG1 SGTC_16 erodoxin 22.806 µM 1.0416968082004 0.118686675609743 no 385 0.148776134639104 816 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_858 0438-0351 2.77 µM 1.03785770107787 0.119503352878203 no 386 0.149668154363923 815 2799119 SGTC_697 0508-1955 564 µM 1.0340919908106 0.120308260401244 no 387 0.150546580075987 813 6243113 SGTC_2764 methyldopa 94.69 µM 1.03392627746875 0.120343768574345 no 388 0.150585314683888 792 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1935 st074532 41.6 µM 1.03105149861182 0.120960936028989 no 389 0.151258335236862 860 2829742 SGTC_2981 9013952 38.96 µM 1.03009351023461 0.121167094149879 no 390 0.151483055706186 692 2996344 SGTC_1320 1313-0481 95.3 µM 1.03005453000943 0.121175487883958 no 391 0.151492204204017 813 6813365 YLR208W SEC13 SGTC_1209 2323-2347 50.3 µM 1.02892712356663 0.121418432839092 no 392 0.151756960794954 774 5412760 SGTC_1843 st055809 45.5 µM 1.02867151549134 0.121473561443441 no 393 0.151817029726535 724 16413835 SGTC_1283 0922-0125 16.4 µM 1.0271300394837 0.12180639431878 no 394 0.152179617707564 821 3360884 SGTC_739 1486-1183 203 µM 1.02587461266976 0.122077936932065 no 395 0.152475345331752 811 4346692 SGTC_2488 5268135 45.7 µM 1.02403929195026 0.122475672237259 no 396 0.152908358275647 845 1270356 YLR208W SEC13 SGTC_732 3970-1727 52.7 µM 1.02176290122461 0.122970254731923 no 397 0.153446566006621 793 1275699 SGTC_1273 0849-0096 14.1 µM 1.01806209289805 0.123777300344197 no 398 0.154324224256066 773 5286025 SGTC_651 3253-0966 34.4 µM 1.01741288632624 0.123919256050141 no 399 0.154478527167378 806 781462 SGTC_1486 3970-0793 4.53 µM 1.01721561364599 0.123962414318096 no 400 0.154525434980873 797 2844330 SGTC_2861 9024595 19.48 µM 1.01640730626292 0.124139361358357 no 401 0.154717733914255 708 16482810 SGTC_126 0417-1624 672.48 µM 1.01376902586913 0.124718138210414 no 402 0.155346489182999 936 41912 YDL195W SEC31 SGTC_2138 5575593 77.673 µM 1.01339162698239 0.124801084605772 no 403 0.155436568592672 760 762213 SGTC_3139 9095020 49.47 µM 1.01065341129229 0.125404056266837 no 404 0.156091171277799 630 25236292 SGTC_2064 5220758 200 µM 1.01057367495344 0.125421645108059 no 405 0.156110260368938 825 788518 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.00704185898582 0.126202447422447 no 406 0.156957329556466 755 689007 SGTC_2859 9028643 45.46 µM 1.00568903155193 0.126502421622428 no 407 0.157282590524855 767 17151580 SGTC_1031 k035-0009 16 µM 1.0045475676785 0.126755914415023 no 408 0.157557377699147 859 5180959 SGTC_1801 st050089 28.441 µM 1.00342864836843 0.127004743657382 no 409 0.157827043657952 883 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1527 coumarin 137 µM 1.00052911419753 0.127651133625615 no 410 0.15852725765701 746 323 A hepatotoxic, DNA x-linker. SGTC_3310 9130229 44.1445 µM 0.999591493848327 0.127860644793765 no 411 0.158754120650655 779 7761258 SGTC_920 mycophenolic acid 780.421 nM 0.999266007209203 0.127933430591149 no 412 0.158832923879142 772 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_249 wiskostatin 11.211 µM 0.999123544307533 0.127965297409384 no 413 0.15886742348824 819 2775510 A n-wasp and actin depolymerizer. SGTC_1103 duloxetine 36.1 µM 0.999090730433464 0.127972638163095 no 414 0.158875370574448 880 60835 A selective serotonin reuptake inhibitor. SGTC_1118 chelidonine 707.474 nM 0.994832635364808 0.12892769482701 no 415 0.159908835391376 866 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3010 9080089 71.4286 µM 0.994020800084594 0.129110342624992 no 416 0.160106370568545 820 17027233 SGTC_33 0986-0033 35.816 µM 0.988303333190116 0.130401746697856 no 417 0.161502056746733 787 2848082 SGTC_1759 st043059 70 µM 0.985728167989871 0.130986307783661 no 418 0.162133261550595 824 669426 SGTC_2752 diclazuril 33.15 µM 0.985673495603168 0.130998737982324 no 419 0.162146679820048 977 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.985618877355965 0.131011156685725 no 420 0.162160085524063 790 5355888 SGTC_3260 9137109 49.47 µM 0.984086164362575 0.131359985640981 no 421 0.162536574536112 687 17478346 SGTC_3076 9116187 49.47 µM 0.981815661514294 0.131877905366731 no 422 0.163095335526829 782 27241210 SGTC_2634 4'-methoxyflavone 100 µM 0.981018082856544 0.132060173264176 no 423 0.163291912168166 753 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2959 9079155 11 µM 0.980874773302306 0.132092941703926 no 424 0.163327249519818 757 16189457 SGTC_39 0986-0283 58.349 µM 0.980217856573165 0.132243220720765 no 425 0.163489295997703 892 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_937 3122-0005 46.7 µM 0.979471436747315 0.132414117829794 no 426 0.163673547541752 867 759535 SGTC_3178 9107506 49.47 µM 0.979153634924293 0.132486926558635 no 427 0.163752036890878 810 8897194 SGTC_784 4579-0127 173 µM 0.978860732035957 0.132554055339702 no 428 0.163824398438561 883 1948547 SGTC_3190 9110366 49.47 µM 0.977698822579649 0.132820577729916 no 429 0.164111652144144 726 17123768 SGTC_1098 clofazimine 15.1 µM 0.977184059262389 0.132938773615494 no 430 0.164239019158802 862 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_65 0798-0905 34.986 µM 0.976988364213183 0.132983726558398 no 431 0.164287456465209 902 3602145 SGTC_2130 NSC 7 2.4545 µM 0.976794641597874 0.133028236720888 no 432 0.164335414688335 858 21448 SGTC_2472 5377652 49.4 µM 0.976504927633255 0.133094821215257 no 433 0.164407153590791 836 1610903 SGTC_1565 sinapyl alcohol 95.1 µM 0.975612362846533 0.133300102125327 no 434 0.164628297868083 786 5280507 A phenol propionate derived from cinnamic acid. SGTC_2902 5787006 60.46 µM 0.974934045045106 0.133456253995426 no 435 0.164796488570066 792 591003 SGTC_959 1222-0044 107 µM 0.97443102662777 0.133572132357731 no 436 0.164921285172047 840 6083612 SGTC_979 1426-2828 121 µM 0.973506884270492 0.133785203659647 no 437 0.165150720186498 874 747872 SGTC_607 4491-0986 66.8 µM 0.970779963334165 0.134415286970517 no 438 0.165828931167576 869 698981 YDR232W HEM1 SGTC_2729 fluphenazine 10.66 µM 0.969730546804765 0.134658307580392 no 439 0.166090410026946 860 3372 An atypical antipsychotic. SGTC_2096 5468907 200 µM 0.968309567588309 0.134987853852661 no 440 0.1664448939621 837 759785 SGTC_1967 st070177 51.4 µM 0.968195498737184 0.135014332084275 no 441 0.166473371260033 814 5729214 SGTC_717 1532-0246 73.2 µM 0.967468353402405 0.135183204418994 no 442 0.166654977080136 820 9561992 SGTC_2834 9001755 58.44 µM 0.965926734536621 0.135541709023822 no 443 0.167040421784655 755 2989575 SGTC_575 k072-0246 11.9 µM 0.964714608166576 0.13582404697721 no 444 0.167343888182923 859 6796779 SGTC_3150 9097574 49.47 µM 0.96421069208056 0.135941541491917 no 445 0.167470152456843 829 17217476 SGTC_890 0929-0006 47.2 µM 0.963564540803287 0.13609230176747 no 446 0.167632145833362 819 1378169 SGTC_1368 1852-0141 284 µM 0.961833621676097 0.136496724255756 no 447 0.168066593082287 800 2838987 SGTC_3128 9127691 49.47 µM 0.961741616374449 0.136518243918261 no 448 0.168089705960411 734 41316314 SGTC_1398 3558-0053 112 µM 0.961309092988803 0.136619440457235 no 449 0.168198388631099 777 4532369 SGTC_538 2922-0838 53.3 µM 0.960430490028016 0.136825163143929 no 450 0.168419299472521 935 777039 SGTC_309 k408-0051 1.48 µM 0.958275954198857 0.137330538264375 no 451 0.16896181284554 885 3640463 SGTC_2199 6590217 200 µM 0.956938740335331 0.137644839937644 no 452 0.169299087995826 783 703109 SGTC_2747 doxorubicin 7.63 µM 0.956737364044531 0.137692214361638 no 453 0.169349917002493 667 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2413 inermin 26.06 µM 0.95488868618913 0.138127641773441 no 454 0.169816995893462 872 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1379 2144-0755 36.5 µM 0.954859401527193 0.138134546867834 no 455 0.169824401468814 904 5392327 SGTC_1181 1222-0449 220 µM 0.95427675941574 0.138271978253032 no 456 0.169971784445024 853 658318 SGTC_2015 5119600 184 µM 0.952298897981101 0.138739203732571 no 457 0.170472708281343 869 2828786 SGTC_2602 kawain 100 µM 0.950010549780524 0.139281115128072 no 458 0.171053446054627 920 5369129 SGTC_2461 5755302 26.15 µM 0.949959847285606 0.139293138442481 no 459 0.171066327663777 867 2788904 SGTC_2184 6075246 200 µM 0.949647259398619 0.139367279434885 no 460 0.171145758268145 843 2267320 SGTC_1210 3013-0140 750 nM 0.9431208863674 0.14092136665966 no 461 0.17280953678751 924 905973 SGTC_2648 atorvastatin 78.68 µM 0.940041447327111 0.141658722259978 no 462 0.173598150496066 846 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1882 5615643 20 µM 0.939255173157695 0.141847409601274 no 463 0.173799873913385 833 2253075 SGTC_3034 9090421 49.47 µM 0.937964170902815 0.142157588816932 no 464 0.174131411616411 834 17173761 SGTC_1272 0839-0021 27 µM 0.937267985119339 0.142325046413076 no 465 0.174310363339218 871 5027250 SGTC_313 3474-0040 5.03 µM 0.936149710905169 0.142594310640716 no 466 0.174598055672859 869 1043375 YIL048W NEO1 SGTC_1381 2324-0066 62.1 µM 0.934636450929963 0.142959229869238 no 467 0.174987843622977 818 10885928 SGTC_1763 st044482 94.5 µM 0.934466001720161 0.143000372820793 no 468 0.175031782777799 887 88505 SGTC_247 mechlorethamine 29.705 µM 0.932140248226699 0.143562561517688 no 469 0.175632025088536 828 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.930489647634616 0.14396245396929 no 470 0.176058810860139 912 3256 An antibiotic and ribosome inhibitor. SGTC_2736 butenafine 14.65 µM 0.93038401651396 0.143988070866925 no 471 0.176086145592699 899 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2536 dehydroabietamide 32.04 µM 0.928655801632538 0.144407621696129 no 472 0.176533746549248 914 3983547 SGTC_2504 purpurogallin 52.29 µM 0.928563730235692 0.144429996539361 no 473 0.176557612856999 840 5281571 An antioxidant. SGTC_1176 0848-0131 83.3 µM 0.928382510079412 0.144474042801646 no 474 0.176604593841011 942 6769040 SGTC_1010 4112-3296 15.2 µM 0.927748563719739 0.144628197132819 no 475 0.176769005432626 922 704384 SGTC_2133 5320837 200 µM 0.926525454764281 0.144925928906746 no 476 0.177086487444588 813 2841355 SGTC_1073 triclabendazole 3.09 µM 0.926505194804331 0.144930864100811 no 477 0.177091749347151 930 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1832 st054113 55 µM 0.925449572328887 0.145188163385084 no 478 0.177366051514356 856 1251267 SGTC_1115 galangin 695.678 nM 0.921555582740123 0.146139948282509 no 479 0.178380218023369 972 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3266 9136860 49.47 µM 0.921295534510966 0.146203659285797 no 480 0.178448075939253 856 4871271 YPR165W RHO1 SGTC_2024 5144227 134 µM 0.919237208124294 0.1467086009467 no 481 0.178985756612936 931 3475211 SGTC_21 0849-0113 22.993 µM 0.915570596522601 0.147610977311299 no 482 0.179946079590998 888 1560156 SGTC_2476 5806916 10.51 µM 0.915397466042217 0.147653677541381 no 483 0.179991504085813 863 2870194 SGTC_1511 0906-3109 28.5 µM 0.915082723499594 0.147731325610403 no 484 0.180074101983644 977 2882180 SGTC_3131 9127911 49.47 µM 0.910758908125015 0.148800793772313 no 485 0.181211208997811 842 45595681 SGTC_1224 0823-0416 294 µM 0.908005975951068 0.149484403329006 no 486 0.181937532177537 913 3598164 SGTC_648 0375-0473 33.3 µM 0.903743943882634 0.150546881899887 no 487 0.183065595927534 925 1713139 SGTC_74 000s-0487 160.283 µM 0.903606170517284 0.15058131103296 no 488 0.183102134088386 964 677548 SGTC_1968 st069590 43.6 µM 0.903408327948193 0.150630760443788 no 489 0.18315461084816 878 6384066 SGTC_1886 st057356 49.9 µM 0.902344775080661 0.150896773597361 no 490 0.183436873709375 856 24207747 SGTC_2073 5212005 126 µM 0.900877936315707 0.151264168337921 no 491 0.183826611739486 815 691789 SGTC_2358 9037157 4 µM 0.900322102999393 0.151403541574041 no 492 0.18397443091285 894 2388925 SGTC_2312 7706453 155.7 µM 0.900289191782758 0.151411796622073 no 493 0.183983185693125 878 976098 SGTC_687 k029-0044 34.9 µM 0.900215050355376 0.151430394449701 no 494 0.184002909156791 962 5829338 SGTC_523 1934-0222 13.7 µM 0.899544601664194 0.151598640507219 no 495 0.184181324958206 886 1361595 SGTC_2761 levamisole 97.89 µM 0.899100990111263 0.151710031096669 no 496 0.184299435386322 892 26879 An alkaline phosphatase inhibitor. SGTC_2329 6138490 200 µM 0.898785593202835 0.151789260143595 no 497 0.184383437655929 780 720019 SGTC_1508 1080-0625 72.9 µM 0.897837354107239 0.152027627408124 no 498 0.184636133454654 865 767111 SGTC_609 0986-0026 86.3 µM 0.894874520447436 0.152774022435971 no 499 0.185427084296223 917 2848610 SGTC_1972 st070201 17.4 µM 0.89211915751768 0.153470329053592 no 500 0.186164533751182 920 2829099 SGTC_1794 st048918 76.9 µM 0.890771082142583 0.153811765208959 no 501 0.18652599594567 853 672303 SGTC_3199 9111318 49.47 µM 0.890251621898943 0.153943466509982 no 502 0.186665395807886 894 8548020 SGTC_91 0417-1751 58.384 µM 0.887263029632243 0.154702628252196 no 503 0.187468652507227 1064 6795624 SGTC_401 neomycin 50 µM 0.885869323114694 0.155057501721025 no 504 0.187843974270506 891 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_552 k242-0005 476 µM 0.882555353908724 0.155903480352814 no 505 0.188738279863173 907 4088318 SGTC_1973 st070275 50.2 µM 0.880281528072776 0.156485691541673 no 506 0.189353408410961 918 17118334 SGTC_1402 3909-7673 35.9 µM 0.879236379950662 0.156753780483698 no 507 0.189636561427479 915 5328014 SGTC_2608 thymoquinone 42.66 µM 0.878855346805881 0.156851593708248 no 508 0.189739856225407 890 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1988 st071872 53.4 µM 0.877655153608704 0.157159952075368 no 509 0.190065444340295 964 16414116 SGTC_2158 5657123 3.6195 µM 0.877619839565006 0.157169031131934 no 510 0.19007502952266 953 2858827 SGTC_632 0781-2353 4.65 µM 0.877195461909124 0.157278163391515 no 511 0.190190240280614 966 6811515 YHR007C ERG11 SGTC_2483 5729050 27.16 µM 0.877177599417685 0.157282757972771 no 512 0.190195090560569 1006 2865180 SGTC_2667 digitoxin 100 µM 0.876875509746984 0.157360474694695 no 513 0.19027712979269 913 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_368 fentichlor 4.58 µM 0.874735134019821 0.157911838697932 no 514 0.190859019316134 867 7329 A pesticide. SGTC_2238 6671620 73.2395 µM 0.874417973329471 0.157993647551569 no 515 0.190945336435321 982 729941 SGTC_1811 st050069 61.5 µM 0.872254374856757 0.158552471270216 no 516 0.191534810933008 947 3877702 SGTC_3062 9077494 49.47 µM 0.871730719072305 0.158687917982008 no 517 0.191677648848833 915 16459633 SGTC_497 capsazepine 133 µM 0.871201724645991 0.158824822569573 no 518 0.191822009208554 960 2733484 A calcium channel blocker. SGTC_1186 1319-0216 26 µM 0.870527090721099 0.158999531177227 no 519 0.192006210523815 999 4565136 SGTC_1061 3448-9325 110 µM 0.869739103369224 0.159203754074734 no 520 0.192221498745432 931 723482 SGTC_1876 myriocin 605 nM 0.869698888938472 0.15921418106544 no 521 0.192232489800934 975 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.868701939173574 0.159472817974383 no 522 0.192505090247982 1001 676296 Flavone; oxidizing agent. SGTC_2892 9047358 58.44 µM 0.868572852012019 0.159506326928343 no 523 0.192540404402143 881 6466771 SGTC_3226 9131256 49.47 µM 0.867215657655329 0.159858911728748 no 524 0.192911929382553 863 17178073 SGTC_452 diindolylmethane 8 µM 0.865985811831711 0.160178852689755 no 525 0.193248971239838 874 3071 Inhibits expression of several cancer promoting factors. SGTC_121 0557-0495 61.343 µM 0.860644857307623 0.161573139867011 no 526 0.194716836097963 1158 3104427 SGTC_606 k015-0008 38.6 µM 0.858935198739379 0.162021122882367 no 527 0.195188134267829 1036 1970475 SGTC_745 0469-0705 296 µM 0.858419333924539 0.16215645402933 no 528 0.195330477729945 1048 3486736 SGTC_2944 9067346 25.62 µM 0.857825493153885 0.162312332373193 no 529 0.195494415293477 892 6473075 SGTC_793 0488-0545 106 µM 0.857797252167442 0.162319747829986 no 530 0.195502213670468 943 292548 SGTC_994 3910-0338 138 µM 0.855919250831726 0.162813364266811 no 531 0.196021222952347 989 3479481 SGTC_1345 1488-0192 31.4 µM 0.855262749214152 0.162986150079836 no 532 0.196202852405503 997 658348 SGTC_3249 9135183 49.47 µM 0.854027502662767 0.163311579826365 no 533 0.196544875468311 998 4902779 SGTC_3182 9108849 49.47 µM 0.853664177883357 0.163407379216709 no 534 0.196645543898722 1009 17133045 SGTC_2218 6965428 192.983 µM 0.849881707011966 0.164406886980222 no 535 0.19769542843869 978 675684 SGTC_303 1348-1668 34.2 µM 0.847694517244397 0.164986650609516 no 536 0.198304060288535 957 5380509 SGTC_2946 9065502 71.43 µM 0.844462952847656 0.165845668975561 no 537 0.199205378492243 813 16489101 SGTC_3125 9127534 49.47 µM 0.844008775692786 0.165966630198217 no 538 0.199332250872068 881 1639235 SGTC_2201 6605497 169.863 µM 0.843184830511521 0.166186217417116 no 539 0.199562540478591 986 670741 SGTC_1597 7-benzyloxygramine 47.5 µM 0.842272124896458 0.166429678901327 no 540 0.199817825130562 1046 260807 SGTC_1531 st059297 52.4 µM 0.841908895216335 0.166526633354329 no 541 0.199919475442968 990 7566702 SGTC_340 k038-0059 454 µM 0.840250886605952 0.16696965736395 no 542 0.20038386616478 999 23733424 SGTC_400 oxethazaine 37.5 µM 0.839935493430611 0.167054017174308 no 543 0.200472277767878 936 4621 A local anesthetic. SGTC_1982 st072467 71.9 µM 0.837027291572399 0.167833183458831 no 544 0.20128861381317 997 3163533 SGTC_907 3448-6986 75.5 µM 0.8362145079302 0.168051362350084 no 545 0.201517119053792 1039 590582 SGTC_287 k060-0039 29.6 µM 0.833667985756591 0.168736117058471 no 546 0.202234051626906 1016 5861974 SGTC_2670 beta-carotene 100 µM 0.829961999628557 0.169735848094201 no 547 0.203280134492801 946 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1718 roemerine 11.9335 µM 0.828453232247703 0.17014394077497 no 548 0.203706935164991 972 235224 An aporphine alkaloid with mutagenic activity. SGTC_2269 7935389 174.42 µM 0.827112148328189 0.170507205652504 no 549 0.20408674960328 959 97605 SGTC_997 3996-0078 137 µM 0.826555148310113 0.17065822838663 no 550 0.204244624005475 1030 735687 SGTC_1008 4106-0037 6 µM 0.823629843031499 0.171452789056056 no 551 0.205074956870625 1000 2905394 SGTC_1174 0739-0097 51.1 µM 0.823007904001718 0.171622022133693 no 552 0.205251749337821 1002 728447 SGTC_2433 5607874 27.82 µM 0.821854559228334 0.171936136028627 no 553 0.205579838819752 1016 2252428 SGTC_2898 9056270 58.44 µM 0.819904941878686 0.172467949182888 no 554 0.20613514966254 966 19154699 SGTC_2664 lyso-paf C-16 73.48 µM 0.818348348029662 0.172893306457383 no 555 0.206579153180757 1060 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3041 9091929 49.47 µM 0.81750734154854 0.173123399124958 no 556 0.206819277753984 1085 25236887 SGTC_99 0109-0120 622.8 µM 0.817211867539381 0.173204284735828 no 557 0.206903680841386 995 759414 SGTC_968 1309-0633 340 µM 0.816089838501837 0.173511657837771 no 558 0.207224377634616 1018 3761976 SGTC_2207 7258803 200 µM 0.815787041756124 0.173594666631002 no 559 0.207310972928475 983 3666799 SGTC_2915 7971052 15.16 µM 0.81431852601663 0.173997604362425 no 560 0.207731249662579 894 5741558 SGTC_123 0083-0120 66.675 µM 0.81415754450136 0.174041811307494 no 561 0.207777351795851 1003 16001701 SGTC_424 splitomicin 100 mM 0.814146089604695 0.174044957195321 no 562 0.207780632497022 938 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3048 9093155 49.47 µM 0.81354298702427 0.174210639867245 no 563 0.207953405272468 996 25236002 SGTC_2742 clothiapine 36.27 µM 0.812722147623971 0.174436299585998 no 564 0.208188690061075 976 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2215 7188065 200 µM 0.810595927818314 0.175021688747326 no 565 0.208798878086837 1025 940217 SGTC_1633 st005664 67.9 µM 0.807463603990137 0.175886345360837 no 566 0.209699717661921 1070 2063822 SGTC_865 0488-0499 301 µM 0.80661218148412 0.176121841560013 no 567 0.209944976678663 1077 9634651 SGTC_2389 9091542 195.52 µM 0.80637768226945 0.176186737081816 no 568 0.210012555636997 1008 3626624 YOL127W RPL25 SGTC_98 0074-0023 107.663 µM 0.806268387835894 0.176216988490899 no 569 0.210044056927519 1049 3563821 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.806044964643941 0.176278839621134 no 570 0.210108461515181 1080 5106787 A p450 inhibitor. SGTC_654 1124-0271 80.9 µM 0.804361701959567 0.176745265463033 no 571 0.210594056292386 1023 5403748 SGTC_184 1494-0393 24.714 µM 0.802011078640508 0.177397918677348 no 572 0.211273274886034 1029 3090647 SGTC_1358 1509-0022 2.48 µM 0.801035283992081 0.177669295496135 no 573 0.211555609773505 1055 3258434 SGTC_1269 0831-0796 3.05 µM 0.799860336501401 0.17799640581489 no 574 0.2118958601794 1055 927758 SGTC_2900 5328528 85.29 µM 0.798688852780399 0.178322929620515 no 575 0.212235426022411 1125 795359 SGTC_194 1486-1323 56.904 µM 0.7984287303993 0.178395483853073 no 576 0.212310868132681 1056 5178754 SGTC_3176 9106582 49.47 µM 0.796887043325966 0.178825878214272 no 577 0.212758318211815 943 17018027 SGTC_1930 st074634 34.3 µM 0.795097061479919 0.179326408524637 no 578 0.213278521930235 1073 684253 YOR116C RPO31 SGTC_299 1273-0059 1.44 µM 0.794914992940027 0.179377369428382 no 579 0.21333147612995 1018 2848077 SGTC_1798 st045719 60.953 µM 0.79346894657374 0.179782440452522 no 580 0.213752327385752 1011 3980186 SGTC_2160 5660466 132.927 µM 0.791842098941282 0.180238844411565 no 581 0.214226375816183 990 2859134 SGTC_1255 0566-0045 221 µM 0.791338252218045 0.180380343438661 no 582 0.214373316069048 1044 2788469 SGTC_2065 5221596 34.26 µM 0.791136145180952 0.1804371222435 no 583 0.21443227438928 1011 788581 SGTC_566 0958-0068 16.5 µM 0.789376907081422 0.180931826073832 no 584 0.214945874427164 1014 6815365 SGTC_813 k007-0158 173 µM 0.787866053827352 0.181357361000143 no 585 0.215387529566704 1109 6523916 SGTC_44 0929-0055 61.211 µM 0.786856444891592 0.181642068422356 no 586 0.215682953363491 1019 1379590 SGTC_3111 9122088 49.47 µM 0.786394471053721 0.18177243720987 no 587 0.215818210802663 968 16876704 SGTC_3246 9135460 32.98 µM 0.785727771273274 0.181960682720282 no 588 0.216013494870552 1013 41446951 SGTC_1924 st058459 75.1 µM 0.782037171457647 0.183004943156203 no 589 0.217096364281651 1063 688683 SGTC_1313 1220-0047 237 µM 0.780882459589813 0.183332437006322 no 590 0.217435814685439 1090 3528706 SGTC_816 0325-0417 81.3 µM 0.777908378626231 0.184177612900467 no 591 0.218311514244421 1073 68101 SGTC_294 k038-0071 157 µM 0.777327994100405 0.18434282924253 no 592 0.21848264147166 1074 24152826 SGTC_1521 st012942 49.4 µM 0.775170653577854 0.184957761019779 no 593 0.219119413294732 1098 24207259 SGTC_375 3970-0961 9.27 µM 0.774005266066211 0.18529047454953 no 594 0.21946383855966 1053 2898222 SGTC_1410 3909-8106 77.9 µM 0.773024798619737 0.185570681795048 no 595 0.219753852253562 1097 1039210 SGTC_2296 7971656 126.45 µM 0.772805214832806 0.185633472545434 no 596 0.219818833358806 1081 666570 SGTC_103 0844-0104 51.839 µM 0.772068986791537 0.185844095704512 no 597 0.220036784699435 1151 5375804 SGTC_2046 4110841 106 µM 0.771428897089276 0.186027335605048 no 598 0.220226376164156 1091 44119630 YMR134W ERG29 SGTC_1171 0368-0077 21.4 µM 0.770881103723377 0.186184242542449 no 599 0.220388704263346 1033 3239779 SGTC_1155 4088-0394 48.2 µM 0.76988308375373 0.186470320692389 no 600 0.220684624648931 1075 2326248 SGTC_2840 9008771 71.43 µM 0.769208709437318 0.186663781252465 no 601 0.220884710461612 1056 2992978 SGTC_763 3453-1109 128 µM 0.768854179331354 0.186765536593082 no 602 0.220989940632105 1111 1560353 SGTC_1629 st005085 44.9 µM 0.768749308626591 0.186795642602518 no 603 0.221021073422398 1076 24207091 SGTC_622 1348-1566 26.3 µM 0.767879819604886 0.187045368928139 no 604 0.221279293833524 1132 7340407 SGTC_2166 5933061 31.504 µM 0.767481047670351 0.187159969438434 no 605 0.221397778612019 1275 2877375 SGTC_2263 7948595 193.29 µM 0.765058424351728 0.187857124505715 no 606 0.22211837771945 1001 2971371 SGTC_1169 aniline yellow 25.8 µM 0.764673003104376 0.187968184333173 no 607 0.222233142950124 1071 6051 A DNA damaging agent. SGTC_2204 7233102 200 µM 0.763806039214726 0.18821814964225 no 608 0.222491418685776 1037 2172480 SGTC_2325 6158266 200 µM 0.763170915340733 0.188401400335238 no 609 0.222680735937684 1102 3623240 SGTC_286 k060-0067 22.9 µM 0.76184131712628 0.188785382134359 no 610 0.223077358747762 1069 5985051 SGTC_2192 5915882 198.485 µM 0.761450094098969 0.188898457302133 no 611 0.223194138204797 1050 2876149 SGTC_2505 galangin 7.89 µM 0.760514896449921 0.189168926477233 no 612 0.22347343420965 1003 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2368 9071271 200 µM 0.758499265390889 0.189752678906744 no 613 0.224076076315683 1089 27209959 SGTC_2516 gossypol 71.55 µM 0.757090514468739 0.190161328104595 no 614 0.224497818252956 1119 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1217 1183-1422 255 µM 0.754784130325941 0.190831528249903 no 615 0.225189258699394 1150 2849664 SGTC_27 0485-0001 32.618 µM 0.753783513584978 0.191122742464542 no 616 0.225489612536487 1045 2054479 SGTC_2323 6148992 148.28 µM 0.752693245902444 0.191440358239908 no 617 0.225817134770336 1036 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2737 bleomycin 30.5 nM 0.750960085626795 0.191945926144334 no 618 0.226338338767642 1161 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2744 captopril 92.04 µM 0.750698344727369 0.192022347690719 no 619 0.226417109719001 1071 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_855 0428-0020 25 µM 0.749816132002907 0.192280068018101 no 620 0.226682725730989 1058 6812414 SGTC_128 0906-2981 13.371 µM 0.749768776173671 0.192293908031203 no 621 0.226696988563466 1048 6740226 SGTC_797 k781-0471 270 µM 0.749674916870473 0.192321340752123 no 622 0.226725259008944 1126 23738129 SGTC_1166 k206-0078 225 µM 0.74935253902294 0.192415581940339 no 623 0.226822374446406 1142 5404595 SGTC_2641 levomentholum 100 µM 0.74734625307944 0.193002716892311 no 624 0.227427289769376 1086 16666 SGTC_1141 3253-0389 52.6 µM 0.746678328404651 0.193198425992328 no 625 0.227628877199203 1120 5402031 SGTC_898 1000-0849 28.3 µM 0.746641225186053 0.193209301183944 no 626 0.227640078330436 1125 6751807 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.745528518600679 0.193535616236024 no 627 0.227976138700761 1143 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_505 gw-5074 63.9 µM 0.744518362142473 0.193832148107665 no 628 0.228281468344307 1096 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_756 0508-1999 28.3 µM 0.742694638946118 0.194368203702242 no 629 0.228833288116741 1128 6753853 SGTC_364 0083-0097 67.7 µM 0.741864496188145 0.194612510134349 no 630 0.229084719383566 1127 5207356 SGTC_708 3448-5400 146 µM 0.741014083469785 0.194862975562829 no 631 0.229342450569207 1135 3462195 SGTC_2640 pentamidine 10.38 µM 0.740699935039944 0.194955548814074 no 632 0.229437699376453 1149 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_547 1120-0019 610 nM 0.73930483981007 0.19536697840125 no 633 0.229860955555722 1081 3676939 SGTC_1774 st048371 48.465 µM 0.735954251228759 0.196357257801864 no 634 0.230879269849139 1136 4242727 SGTC_1590 st077108 57.8 µM 0.735552536000897 0.196476190214483 no 635 0.23100152843829 1112 5489485 SGTC_779 1360-0071 233 µM 0.733332334533769 0.197134293388228 no 636 0.231677879151844 1206 7566 SGTC_427 1354-0053 47.3 µM 0.732346647700584 0.197426893751169 no 637 0.231978507049304 1135 6813657 SGTC_3100 9120536 49.47 µM 0.731874432808166 0.197567163368438 no 638 0.232122606357687 1038 16421196 SGTC_2870 9038528 12.99 µM 0.730749253794995 0.197901636185476 no 639 0.232466162438405 1125 6463316 SGTC_737 1950-0117 57.9 µM 0.730705115919466 0.197914763661252 no 640 0.232479645020359 1126 5393513 SGTC_48 0382-0018 55 µM 0.729079241308331 0.198398697358762 no 641 0.232976595951608 1237 762596 SGTC_2475 5812728 15.03 µM 0.725397431575058 0.199497206125578 no 642 0.234104124157443 1176 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_590 k048-0076 22.4 µM 0.724888367210128 0.199649378694915 no 643 0.234260258969147 1133 6832814 SGTC_3118 9124250 49.47 µM 0.723896370957974 0.199946112743137 no 644 0.234564679059703 1047 1504786 SGTC_19 0279-0214 38.434 µM 0.723493056559829 0.200066831240001 no 645 0.234688509206944 1228 3566274 YBR002C RER2 SGTC_1050 3232-1156 69.3 µM 0.721618617450507 0.200628455832746 no 646 0.235264494818238 1108 700529 SGTC_2607 solasodine 47.35 µM 0.721354620750898 0.200707631224161 no 647 0.235345679501226 1159 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1863 st057641 20.1 µM 0.720217104279562 0.20104899886181 no 648 0.235695667177111 1185 3921635 SGTC_2989 9073649 71.4286 µM 0.719426125245935 0.201286576081993 no 649 0.235939202339693 1166 21367202 SGTC_2748 diazoxide 86.69 µM 0.717027965717333 0.202007911507969 no 650 0.236678420557563 1096 3019 A potassium channel activatior. SGTC_699 0375-0592 111 µM 0.716876580681411 0.202053498028451 no 651 0.236725126793303 1205 762578 SGTC_2387 9077560 195.08 µM 0.716281927507675 0.202232625301322 no 652 0.236908641879961 1153 5303272 SGTC_1400 3771-8998 51.5 µM 0.7141990913447 0.202860786365292 no 653 0.237552039341336 1127 670767 SGTC_1035 k081-0041 55.2 µM 0.713424093797155 0.203094814525363 no 654 0.237791684140738 1197 731709 SGTC_2941 9056145 11.23 µM 0.713101462547864 0.20319228787963 no 655 0.237891487275902 1087 2119517 SGTC_3133 9127736 49.47 µM 0.712858920958012 0.203265582929143 no 656 0.237966530501505 1180 27243420 SGTC_819 1013-0258 27.7 µM 0.712805865165537 0.203281618269824 no 657 0.23798294788109 1193 5753198 SGTC_2638 epoxomicin 18 µM 0.71212264134704 0.20348818016851 no 658 0.238194417492343 1156 9915668 A protesome inhibitor. SGTC_2701 st077767 14.721 µM 0.710432706530987 0.203999642744484 no 659 0.238717923591027 1188 5721188 SGTC_1846 st056244 14.8 µM 0.709964721846646 0.204141414671364 no 660 0.238863006581252 1170 5393182 SGTC_3155 9099265 49.47 µM 0.709317936769679 0.204337449205469 no 661 0.239063600007662 1111 25236499 SGTC_2421 5690543 90.72 µM 0.709148696912502 0.204388762723945 no 662 0.239116103122563 1169 3397993 SGTC_1265 0819-1001 68.8 µM 0.707446001398002 0.204905446614483 no 663 0.239644679181805 1188 3106768 SGTC_132 0417-1715 25.805 µM 0.705850508291398 0.205390303967997 no 664 0.240140554073708 1210 6769098 SGTC_1841 st054148 70 µM 0.704595043506693 0.205772308092583 no 665 0.240531141950805 1134 675442 SGTC_1871 st057448 67.3 µM 0.702487033512496 0.206414666183053 no 666 0.241187742622189 1261 691747 SGTC_135 0933-0004 26.348 µM 0.701371173776097 0.206755174146069 no 667 0.241535703362432 1149 21230617 YGL099W LSG1 SGTC_120 rhodamine 6G 52.259 µM 0.700933152943444 0.20688892836611 no 668 0.241672366733557 1248 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2366 9070441 60.58 µM 0.699657358217105 0.207278797268112 no 669 0.242070656297334 1209 6837235 SGTC_2074 5212007 75.395 µM 0.69923279644461 0.207408634979711 no 670 0.242203278866517 1127 758611 SGTC_1708 st033234 31.827 µM 0.697434220204631 0.207959201078975 no 671 0.242765546080392 1243 674664 SGTC_1412 3909-8563 178 µM 0.697027001383831 0.208083975413217 no 672 0.242892948009498 1251 23767530 SGTC_2657 nystatin 74.44 µM 0.696044491275136 0.208385204371045 no 673 0.243200483671825 1214 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2435 5706476 10.6 µM 0.695763872030701 0.208471286961321 no 674 0.243288358983644 1209 5725375 SGTC_2807 7945238 51.95 µM 0.695365269765738 0.208593597993312 no 675 0.243413209920093 1217 17148797 SGTC_2220 6782180 200 µM 0.695068437967085 0.208684708252384 no 676 0.243506206607368 1135 833803 SGTC_2010 4012422 159 µM 0.693663480212809 0.209116267471661 no 677 0.243946636771383 1171 952393 SGTC_2360 9040895 200 µM 0.692279867542642 0.209541783295725 no 678 0.244380795321114 1158 4914414 SGTC_2196 6573537 42.6665 µM 0.691213598897551 0.209870050453338 no 679 0.244715659581183 1235 2903087 SGTC_936 3005-4620 401 µM 0.690875754231426 0.209974124142819 no 680 0.244821812036018 1217 777207 SGTC_2121 5257820 149.641 µM 0.689312115943598 0.210456200733781 no 681 0.245313437519607 1244 791256 SGTC_2743 auranofin 4.32 µM 0.689108963628876 0.210518881140844 no 682 0.245377349823903 1152 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3127 9126946 49.47 µM 0.688703064026744 0.21064414979717 no 683 0.245505073807683 1142 27243249 SGTC_700 3453-2283 142 µM 0.687907891086827 0.210889682638012 no 684 0.245755393498247 1263 565664 SGTC_3064 1327-0027 10 µM 0.687848299563586 0.210908090016358 no 685 0.245774158371276 1105 16000455 YPR107C YTH1 SGTC_2866 9034245 58.44 µM 0.687132596364725 0.211129239003696 no 686 0.245999587415982 1206 6462273 SGTC_3096 9117468 49.47 µM 0.685198250078472 0.211727622651247 no 687 0.246609413984054 1119 41316311 SGTC_2275 7947463 200 µM 0.685002467137491 0.211788242720935 no 688 0.246671182069655 1177 1225414 SGTC_857 0438-0306 1.35 µM 0.68296944704031 0.212418324660849 no 689 0.247313074463918 1233 4686136 SGTC_439 amiodarone 34.4 µM 0.682538987279588 0.21255187488151 no 690 0.247449099458239 1169 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_798 1287-0182 476 µM 0.682339906902586 0.212613656187421 no 691 0.247512022241627 1245 1649755 SGTC_2398 5228213 48.84 µM 0.681657871844196 0.212825393993119 no 692 0.247727655972002 1233 80771 YMR134W ERG29 SGTC_934 2950-0684 338 µM 0.681009111590387 0.21302691581184 no 693 0.247932862522188 1227 1121253 SGTC_511 blebbistatin 171 µM 0.68055160790584 0.213169095275647 no 694 0.248077628059747 1255 3476986 A myosin inhibitor. SGTC_2127 5253358 187.912 µM 0.67876901158854 0.213723604479987 no 695 0.248642115713941 1168 20612 SGTC_2101 5377231 179.231 µM 0.677057911929396 0.214256662793475 no 696 0.249184605679395 1216 2844213 SGTC_775 4577-0580 57.3 µM 0.674732258264929 0.214982411483563 no 697 0.249922942920043 1285 2006902 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.674589018143509 0.215027157939995 no 698 0.249968456027969 1310 6728940 SGTC_270 tamoxifen 5.46 µM 0.674490759476595 0.215057855868984 no 699 0.249999679274407 1315 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2309 7664088 163.95 µM 0.674490759476595 0.215057855868984 no 700 0.249999679274407 1246 704922 SGTC_2362 9071156 126 µM 0.674408240729217 0.215083638305031 no 701 0.250025902511012 1233 653133 SGTC_389 tpck 16.7 µM 0.673757395153185 0.215287053581141 no 702 0.250232782743357 1212 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3224 9130643 49.47 µM 0.671936691871324 0.215856688809643 no 703 0.250812000178806 1271 17644395 SGTC_2841 9004761 38.96 µM 0.67131993025164 0.216049850115028 no 704 0.251008370399651 1146 2991039 SGTC_467 ro 31-8220 72.8 µM 0.669486859490986 0.216624533467628 no 705 0.251592480144608 1200 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1407 3909-7909 12.3 µM 0.66938696329576 0.216655877165064 no 706 0.251624332781721 1247 4411780 SGTC_656 4090-1979 187 µM 0.66843878366498 0.216953511126492 no 707 0.251926772868674 1252 22330961 SGTC_1267 0828-0272 9.49 µM 0.667565458110623 0.217227857325286 no 708 0.252205506453706 1268 745334 SGTC_3084 9116877 49.47 µM 0.666992437319735 0.217407974708174 no 709 0.2523884820632 1171 27241325 SGTC_3033 9090887 49.47 µM 0.666590601229046 0.217534335095584 no 710 0.252516837115351 1240 19325384 SGTC_3318 9139014 38.6185 µM 0.665894388809845 0.217753364653582 no 711 0.252739303662019 1240 16643984 SGTC_2708 st078559 56 µM 0.661861466717842 0.219024628870243 no 712 0.254030004471958 1173 17250902 SGTC_2167 5876490 200 µM 0.661492292940018 0.219141213284428 no 713 0.254148327781929 1309 686534 SGTC_2229 7354935 190 µM 0.660411901938219 0.219482603738143 no 714 0.254494768215565 1198 318112 SGTC_686 1319-0111 510 µM 0.658739279396453 0.220011734353017 no 715 0.255031602514593 1311 4562600 SGTC_3337 9144342 33.5465 µM 0.658309504885778 0.220147810704503 no 716 0.255169635813473 1262 17682949 SGTC_2247 cerulenin 830 nM 0.655654423494186 0.220989539172841 no 717 0.256023249930766 1308 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1510 1123-0200 71.5 µM 0.655473905343913 0.221046834826886 no 718 0.256081340922686 1340 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2205 7238770 200 µM 0.655404227695744 0.221068952474738 no 719 0.256103765125579 1281 279867 SGTC_69 0096-0274 206.684 µM 0.655373047457595 0.221078850370596 no 720 0.256113800124102 1367 6741392 SGTC_2151 5563267 85.4165 µM 0.654710810502926 0.221289131623029 no 721 0.256326981838545 1260 5310824 SGTC_1318 1280-3875 124 µM 0.652563767049546 0.221971672179716 no 722 0.257018775366392 1258 373245 SGTC_2837 9008476 45.46 µM 0.650658989938659 0.222578201744893 no 723 0.257633320862625 1286 2992805 SGTC_902 1120-0002 2.07 µM 0.649212289920864 0.223039498571976 no 724 0.258100584503722 1255 3280475 SGTC_3068 9116768 49.47 µM 0.64749478326771 0.22358785138798 no 725 0.258655884854077 1236 41904888 SGTC_2426 5582046 32.21 µM 0.647486953557962 0.223590352954111 no 726 0.258658417753579 1283 2251934 SGTC_653 0203-0016 55.2 µM 0.647429792012825 0.223608616359267 no 727 0.258676909817798 1301 295302 SGTC_1729 st035615 45.989 µM 0.646723917876926 0.223834216656273 no 728 0.258905320254245 1260 17385451 SGTC_736 0958-0254 92.6 µM 0.646699038097396 0.223842170696364 no 729 0.258913372886332 1315 6812352 SGTC_603 3794-0023 45.9 µM 0.643770111525925 0.224779667494675 no 730 0.259862258926167 1268 3802260 SGTC_2143 5623677 140.463 µM 0.642792898196244 0.225092950567123 no 731 0.260179245961869 1237 5375313 SGTC_1256 0570-0116 285 µM 0.642328608878439 0.225241882898526 no 732 0.260329921261536 1256 410638 SGTC_3164 9100705 49.47 µM 0.641458294190624 0.22552120826322 no 733 0.260612484591706 1300 17174235 SGTC_244 nsc-207895 1.295 µM 0.640920999095929 0.225693749640182 no 734 0.260787005900283 1185 42640 SGTC_939 1165-0479 45.3 µM 0.640299865327909 0.225893307139435 no 735 0.260988834144704 1231 1377347 SGTC_2890 9046729 58.44 µM 0.638718407240837 0.226401847237449 no 736 0.261503067920043 1226 903329 SGTC_3018 9082602 49.47 µM 0.636796058168565 0.227020875333491 no 737 0.262128847014045 1270 17332089 SGTC_1891 st059073 26.2 µM 0.635783347001919 0.227347368463605 no 738 0.262458821549252 1324 688754 SGTC_75 0159-0059 199.013 µM 0.632539376833204 0.22839498759056 no 739 0.26351724324111 1404 5377270 SGTC_1822 st052468 42 µM 0.632237072404391 0.228492752828248 no 740 0.263615988025221 1282 2873678 SGTC_2751 anetholtrithion 17.25 µM 0.632017795853558 0.228563681562902 no 741 0.263687624376279 1272 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_897 1000-0139 31.4 µM 0.631509291680309 0.228728213481428 no 742 0.263853787884879 1291 6151020 SGTC_1307 1187-1599 12.2 µM 0.631286870543688 0.228800201098188 no 743 0.263926485043035 1283 1538471 SGTC_1075 aripiprazole 15.2 µM 0.629940356281428 0.229236278044277 no 744 0.264366803909463 1307 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2647 atorvastatin 60.16 µM 0.625463587406743 0.230689452623402 no 745 0.265833419799038 1315 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.625306408313041 0.230740566842894 no 746 0.265884987428923 1272 77254 SGTC_2335 9018011 154.17 µM 0.624937350854258 0.230860608200424 no 747 0.266006088455539 1343 6458208 SGTC_2103 5378138 10 µM 0.624837077846643 0.23089322949228 no 748 0.266038996462257 1330 244142 SGTC_1692 fluoroquinolonic acid 71 µM 0.624278115081529 0.231075121073381 no 749 0.266222476930976 1312 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_692 k241-0027 77.8 µM 0.624268960428311 0.231078100746482 no 750 0.266225482494383 1375 3600480 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.623979360873141 0.231172371201967 no 751 0.266320569764735 1319 2724 A muscle relaxant with antifungal properties. SGTC_250 brefeldin a 552.239 µM 0.623416061764196 0.231355797792635 no 752 0.266505572906087 1233 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_491 tetrandrine 80.3 µM 0.622933031310468 0.231513151195377 no 753 0.266664265332858 1348 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1298 1079-1278 263 µM 0.622770749752987 0.231566029893125 no 754 0.266717591228661 1331 2840950 SGTC_972 1319-0219 195 µM 0.621026332328162 0.232134865213638 no 755 0.267291148856678 1268 23903702 SGTC_1611 st001856 99.4 µM 0.61865109495806 0.232910652920313 no 756 0.268073116969563 1267 647478 SGTC_2619 obliquin 87.91 µM 0.617413695381402 0.233315375827233 no 757 0.268480945471481 1313 6708593 A bioactive alkalod. YER133W GLC7 SGTC_969 1313-0238 134 µM 0.617361900655039 0.233332325111034 no 758 0.268498023042335 1336 5212874 SGTC_1371 2421-0008 32.7 µM 0.61688232428013 0.23348929392209 no 759 0.268656173172368 1324 2827552 SGTC_2118 5526350 200 µM 0.615675993381034 0.233884393578025 no 760 0.269054192332594 1350 743594 SGTC_489 paxilline 115 µM 0.614083393925756 0.234406571495653 no 761 0.269580110549787 1278 105008 A toxic potassium channel blocker. SGTC_2474 5321570 43.32 µM 0.613555148297439 0.234579913848365 no 762 0.269754664836417 1374 2841384 SGTC_3114 9122766 49.47 µM 0.611467009375736 0.23526582448623 no 763 0.270445226258951 1261 17176985 SGTC_2829 7992743 58.44 µM 0.610190570402333 0.235685653120822 no 764 0.270867787737151 1328 16462845 SGTC_1483 3453-0561 55.9 µM 0.609963762831546 0.235760294734142 no 765 0.270942906197818 1337 4546991 SGTC_1051 3253-3903 78 µM 0.609704252776239 0.235845714612598 no 766 0.271028868440144 1289 5509239 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.609425496733856 0.23593748847001 no 767 0.271121221034208 1310 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_749 1000-0129 128 µM 0.609162716260529 0.236024020767448 no 768 0.271208295248453 1412 708470 SGTC_2176 5809774 33.9695 µM 0.609118161602667 0.236038694127441 no 769 0.271223060139435 1315 2870539 SGTC_1417 3966-0327 90.4 µM 0.609031918789839 0.236067098238859 no 770 0.271251641134457 1368 651118 SGTC_2781 5567276 71.43 µM 0.607873359612251 0.236448852773797 no 771 0.271635734840234 1354 2853274 SGTC_1142 3253-1408 9.78 µM 0.607531864906888 0.236561442822229 no 772 0.271749001222094 1323 256655 SGTC_2115 tiliquinol 12.7705 µM 0.605942854270706 0.237085723903079 no 773 0.272276350528093 1345 71208 A bioactive hydroxyquinoline. SGTC_152 4469-0003 551.229 µM 0.604205999946164 0.237659514397443 no 774 0.272853346192555 1330 697280 SGTC_335 4077-0256 27.6 µM 0.600657181436641 0.238834274028252 no 775 0.274034171911562 1343 3121989 SGTC_1805 st050013 60.3 µM 0.600482936494413 0.238892035737198 no 776 0.274092214747661 1330 4037144 SGTC_800 3448-7362 155 µM 0.599238855535464 0.239304666997322 no 777 0.274506807711523 1412 15991913 SGTC_3095 9117207 49.47 µM 0.599037199713747 0.239371587958043 no 778 0.274574039129584 1315 17015229 SGTC_1023 4482-3888 16 µM 0.59842881532822 0.239573546693026 no 779 0.274776921782003 1394 3303168 SGTC_2767 sibutramine 71.45 µM 0.59756048472969 0.239861957991127 no 780 0.275066618669812 1424 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1734 st037168 69.4 µM 0.596691885346203 0.240150647941976 no 781 0.275356555657768 1334 708907 SGTC_635 k038-0028 24.7 µM 0.59663060556045 0.240171022200442 no 782 0.275377016423283 1386 4035102 SGTC_2107 5363541 170.161 µM 0.596480385206187 0.240220971339442 no 783 0.275427176803742 1324 244052 SGTC_631 k072-0230 41.5 µM 0.595778668855734 0.240454371063997 no 784 0.27566154784601 1383 5773147 SGTC_1920 st075728 45.7 µM 0.595258866955033 0.240627343340853 no 785 0.275835223228145 1432 3400306 SGTC_2994 9053520 71.4286 µM 0.594800679420529 0.240779868616021 no 786 0.275988356685265 1372 4647384 SGTC_2933 9026794 32.47 µM 0.594667480668446 0.240824218791632 no 787 0.276032881627983 1386 17586027 SGTC_2235 salicylic acid 500 µM 0.593540741015217 0.24119955848479 no 788 0.276409662984866 1361 338 A COX inhibitor and kinase inhibitor. SGTC_2198 6589944 200 µM 0.593049020431616 0.241363460129643 no 789 0.27657417320359 1319 5290268 SGTC_1091 telmisartan 47.6 µM 0.593028861842682 0.241370180736384 no 790 0.276580918492495 1400 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_428 3448-4153 16.5 µM 0.592499006104689 0.241546864076307 no 791 0.276758243047133 1299 3834874 SGTC_2035 5154463 94.595 µM 0.59201672240944 0.241707745290933 no 792 0.276919695274298 1376 2769623 SGTC_2827 7993847 71.43 µM 0.591123867849725 0.242005739050465 no 793 0.27721871437064 1362 2985692 SGTC_72 0744-0168 198.391 µM 0.59066391571741 0.242159327631221 no 794 0.277372815040506 1370 677577 SGTC_198 3454-2873 16.191 µM 0.59035009117251 0.242264151175294 no 795 0.277477981693057 1327 710957 SGTC_2863 9028737 58.44 µM 0.589826010599883 0.242439259163606 no 796 0.277653651290328 1367 6460917 SGTC_2278 7948257 134.34 µM 0.589647795592765 0.242498820724191 no 797 0.277713400584936 1324 1247028 SGTC_295 k015-0027 31 µM 0.589012011421868 0.242711371863794 no 798 0.277926608057245 1331 3887424 SGTC_2717 st081029 62.2815 µM 0.588756958516815 0.242796667791933 no 799 0.278012161392973 1319 5292846 SGTC_1261 0712-0010 12.7 µM 0.588433631282465 0.242904819639505 no 800 0.278120634705277 1390 2840123 SGTC_161 4065-0411 162.148 µM 0.587068447034783 0.243361756309759 no 801 0.278578868926043 1391 1906281 YLR208W SEC13 SGTC_131 0141-0277 33.849 µM 0.586838490191752 0.243438770150306 no 802 0.278656091817189 1393 1547771 SGTC_1559 coumarin 343 70.1 µM 0.586774369126053 0.243460247003427 no 803 0.278677626472701 1414 108770 A hepatotoxic, DNA x-linker. SGTC_633 0437-0093 97.7 µM 0.586591230298079 0.243521593568509 no 804 0.278739136954755 1360 2831118 SGTC_674 0498-0004 451 µM 0.585683237460177 0.243825869949105 no 805 0.279044200318975 1314 4231473 SGTC_2522 biochanin a 4.94 µM 0.584528669656401 0.244213071918369 no 806 0.279432341172729 1357 5280373 A possible chelator. SGTC_2126 5251174 33.877 µM 0.584161487483122 0.244336281518511 no 807 0.279555834853575 1448 790722 SGTC_2061 5245884 80.95 µM 0.583605027572232 0.244523067940752 no 808 0.279743038446956 1351 573863 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.582919721249072 0.244753209785484 no 809 0.279973671949285 1417 688664 SGTC_1187 1391-0724 117 µM 0.581333098454269 0.245286481932254 no 810 0.280507988698678 1379 6997986 SGTC_1465 k213-0056 144 µM 0.580648367569422 0.24551681633051 no 811 0.280738733473815 1334 24048857 YMR208W ERG12 SGTC_1834 st055981 52.8 µM 0.578339077824758 0.246294486839529 no 812 0.281517608121312 1439 471719 YDL150W RPC53 SGTC_561 1550-0330 72.9 µM 0.578066327662215 0.246386424602664 no 813 0.281609669775117 1328 6812934 SGTC_2077 5212015 200 µM 0.577102490195493 0.246711459181718 no 814 0.281935111119458 1262 780900 SGTC_492 tmb-8 126 µM 0.575445707599516 0.247270711538423 no 815 0.282494949579161 1293 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3238 9133470 49.47 µM 0.575057924292918 0.2474017068755 no 816 0.282626061436568 1448 3534688 SGTC_417 st075190 100 µM 0.574893926268994 0.247457117469112 no 817 0.282681518949078 1453 222757 SGTC_2593 nobiletin 86.24 µM 0.574406337747471 0.247621899893584 no 818 0.282846432586881 1322 72344 An anti-infammatory. SGTC_55 0767-0285 6.563 µM 0.572288998376506 0.248338142265383 no 819 0.283563100902237 1341 3116166 SGTC_1769 st044406 64.4 µM 0.572025613447528 0.248427315898958 no 820 0.283652311161215 1386 670903 SGTC_2844 9010103 25.97 µM 0.571577076677878 0.24857921523654 no 821 0.283804264536735 1379 2480525 SGTC_3090 9117696 49.47 µM 0.571482898580495 0.248611115428844 no 822 0.283836174741137 1443 7923821 SGTC_2327 6189656 200 µM 0.569961374101955 0.249126791288755 no 823 0.284351948171667 1460 5349088 SGTC_3309 9129340 25.759 µM 0.569082286873617 0.249424991107868 no 824 0.284650149249259 1447 17158987 SGTC_616 4092-0450 108 µM 0.568145149277098 0.249743091289642 no 825 0.284968206303086 1417 787165 SGTC_1183 1254-0324 198 µM 0.567455907389179 0.249977183639924 no 826 0.285202237637419 1445 5799357 SGTC_2678 equilin 100 µM 0.567445785270948 0.249980622357602 no 827 0.285205675273979 1461 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3136 9095672 49.47 µM 0.566613963334422 0.250263297280556 no 828 0.285488243041649 1269 17217380 SGTC_3207 9114163 49.47 µM 0.566009203908438 0.250468916759965 no 829 0.285693761897875 1534 849233 SGTC_1921 5740136 50 µM 0.56574636372312 0.250558310879715 no 830 0.285783106320573 1481 1774243 SGTC_165 k038-0023 64.381 µM 0.565398583313051 0.250676619847315 no 831 0.285901343975877 1351 46368543 SGTC_2443 5493264 126.67 µM 0.565083098415147 0.250783968019935 no 832 0.286008621984195 1448 5340055 SGTC_3081 9117243 49.47 µM 0.564742046701778 0.250900043033819 no 833 0.286124615289213 1480 45595589 SGTC_2331 7980721 200 µM 0.562779416808124 0.251568565265498 no 834 0.286792548985322 1420 2981221 SGTC_2932 9016711 44.54 µM 0.560552816622417 0.25232814048106 no 835 0.287551212257856 1457 7117328 SGTC_2307 7538926 6.34 µM 0.558532749255152 0.253018304357605 no 836 0.288240323992391 1399 96582 SGTC_2477 5967686 25.23 µM 0.558435413615809 0.253051584521609 no 837 0.28827354805654 1356 776118 SGTC_3288 9119690 36.221 µM 0.558329302100769 0.253087867881122 no 838 0.288309769692092 1353 17595618 YKL019W RAM2 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.555808117154463 0.253950756427782 no 839 0.289171017948029 1416 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1814 st052110 31.539 µM 0.554938639577142 0.254248697229393 no 840 0.289468315708106 1432 674163 SGTC_2697 mebhydrolin 72.4 µM 0.55479740525207 0.254297110792682 no 841 0.289516621071411 1483 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3340 9146634 11.102 µM 0.554523553833348 0.254390997796523 no 842 0.289610295292791 1396 4907387 SGTC_2679 rapamycin 1 nM 0.554414377404019 0.254428432821688 no 843 0.289647644390028 1396 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3071 9117417 49.47 µM 0.553283310348467 0.254816429236998 no 844 0.290034713757854 1399 45595590 YGL055W OLE1 SGTC_2879 9041815 71.43 µM 0.552612997990481 0.255046516411794 no 845 0.290264219817513 1370 4942971 SGTC_3326 9140064 16.379 µM 0.552464411456546 0.255097533996432 no 846 0.2903151053915 1369 1868434 SGTC_1970 st070122 35.8 µM 0.551775273408884 0.255334221162117 no 847 0.290551165130237 1456 102928 SGTC_663 1486-0733 13.9 µM 0.550351197308805 0.255823689128283 no 848 0.291039257463217 1406 722445 YPR165W RHO1 SGTC_1501 4491-0275 38.4 µM 0.549652784311663 0.25606391892789 no 849 0.2912787736432 1411 5104718 SGTC_2346 9031566 143.75 µM 0.549636478733824 0.256069528885307 no 850 0.291284366633627 1466 4771086 SGTC_1908 st060353 56.5 µM 0.549283986957536 0.25619081985673 no 851 0.291405287396856 1523 4227716 SGTC_1074 carmofur 3.8 µM 0.54926425562483 0.256197610212453 no 852 0.291412056836423 1424 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3040 9091894 49.47 µM 0.548427265618262 0.256485738981523 no 853 0.291699279499 1369 25236966 SGTC_2350 9023895 38.85 µM 0.545901606703824 0.257356204051911 no 854 0.292566786935709 1484 2997209 SGTC_1938 st074717 56.4 µM 0.545035947287444 0.257654905321705 no 855 0.2928643972317 1341 17250979 SGTC_1322 1348-1070 12 µM 0.54450334221282 0.257838773484511 no 856 0.293047574557464 1402 6758089 SGTC_774 k060-0086 136 µM 0.543110879984642 0.258319806672798 no 857 0.29352673101085 1460 5911235 SGTC_2144 5628481 200 µM 0.542190908266505 0.258637870540042 no 858 0.293843498925052 1414 2818399 SGTC_3014 9081533 49.47 µM 0.541731234375544 0.258796870548391 no 859 0.29400183468869 1503 21367265 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.541220121388142 0.258973722579649 no 860 0.294177935069924 1403 279621 SGTC_450 aminopyrene 156 nM 0.540444285909648 0.259242291594042 no 861 0.294445336817011 1455 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2268 7933382 153.85 µM 0.53944906680138 0.259587014724241 no 862 0.294788516152024 1419 935025 YOR257W CDC31 SGTC_2223 6903751 107.57 µM 0.538985124319954 0.259747795560233 no 863 0.294948559468163 1428 5598863 SGTC_490 phenamil 164 µM 0.538455062190831 0.259931553262946 no 864 0.295131460649351 1474 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_458 nppb 133 µM 0.538349195764814 0.25996826222107 no 865 0.295167996763778 1535 4549 A chloride channel blocker. SGTC_346 4513-0042 7.16 µM 0.537172669067303 0.260376400240806 no 866 0.295574174125527 1424 2827372 SGTC_2311 7694451 200 µM 0.536302108942723 0.260678610550545 no 867 0.29587488665529 1482 2163142 SGTC_1790 st045711 43.5 µM 0.535357589999263 0.261006699330818 no 868 0.296201305177957 1556 585119 SGTC_3001 9076041 71.4286 µM 0.534831063842714 0.261189685958113 no 869 0.296383340273219 1415 16004211 SGTC_2374 9071832 200 µM 0.534183945500594 0.261414672941702 no 870 0.296607137746296 1396 17381698 SGTC_3021 9087658 49.47 µM 0.533248001357786 0.261740253466329 no 871 0.296930958738125 1418 25237042 SGTC_726 3448-4391 34.2 µM 0.532776774170464 0.261904254767808 no 872 0.297094056646628 1535 1356692 SGTC_1687 st020778 55.3625 µM 0.532051116486907 0.262156908585016 no 873 0.297345296365811 1453 4259299 SGTC_2444 5485484 36.41 µM 0.531897066059665 0.262210560724455 no 874 0.297398644726384 1542 6790631 SGTC_1397 3532-0190 20.1 µM 0.528237583644096 0.263486724342381 no 875 0.298667223378346 1450 5322280 SGTC_2241 6772625 37.8075 µM 0.527295346666824 0.26381582110971 no 876 0.298994252600211 1388 2285411 SGTC_1877 wortmannin 25 µM 0.52499811196584 0.264619057789273 no 877 0.299792251718098 1456 312145 A covalent inhibitor of PI 3-kinase. SGTC_485 niflumic acid 177 µM 0.52470252759172 0.264722500225764 no 878 0.299894999972164 1474 4488 A COX2 inhibitor. SGTC_477 mead ethanolamide 10 µM 0.524489345787332 0.264797117895478 no 879 0.299969114113876 1374 16061185 SGTC_1516 st013856 110 µM 0.524273515083598 0.264872673621702 no 880 0.300044157606301 1426 5281404 A mutagen and neurotoxin. SGTC_2851 9015922 71.43 µM 0.524143426279634 0.264918219024245 no 881 0.300089393077068 1501 2996893 SGTC_1773 st048542 73.5835 µM 0.523305633267642 0.26521163413387 no 882 0.300380790724851 1359 3237138 SGTC_1250 0485-0349 40.2 µM 0.52258244131939 0.265465045847136 no 883 0.300632431076821 1454 6842794 YDL195W SEC31 SGTC_3042 9091578 49.47 µM 0.522504074304355 0.265492513594553 no 884 0.300659705212735 1414 25236497 SGTC_2976 9009005 19.48 µM 0.522498588929148 0.265494436280163 no 885 0.300661614334149 1585 2993148 SGTC_1914 st062367 72.6 µM 0.520898025628935 0.266055753273499 no 886 0.301218905440561 1437 978205 SGTC_449 xestospongin c 11.1929 µM 0.520817562828016 0.266083987409365 no 887 0.301246933609077 1494 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3282 9108498 15.4605 µM 0.520336723838837 0.266252743873205 no 888 0.30141445208529 1422 16459645 SGTC_2533 agelasine 13.65 µM 0.519170495200637 0.266662271336292 no 889 0.301820926080072 1595 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2208 7283366 200 µM 0.517053653041665 0.26740642455336 no 890 0.302559352881433 1525 898663 SGTC_2434 5670830 169.91 µM 0.516612915404049 0.267561492799761 no 891 0.302713199005942 1453 1549830 SGTC_1246 0422-0085 105 µM 0.51646622448288 0.267613114293203 no 892 0.302764411457587 1492 264295 SGTC_624 k048-0052 28 µM 0.515786594641235 0.267852345968885 no 893 0.303001733136726 1455 6835531 SGTC_3236 9132701 49.47 µM 0.515642222112466 0.267903179386894 no 894 0.303052157666323 1418 24282524 SGTC_1242 0402-0103 60.1 µM 0.515185283223672 0.268064099114965 no 895 0.303211775984119 1419 432868 SGTC_3126 9127922 49.47 µM 0.515123431861759 0.268085884987798 no 896 0.303233384847643 1477 45595682 SGTC_1664 st014217 9.02 µM 0.51448595617154 0.268310474632464 no 897 0.303456138321417 1518 3982782 SGTC_1365 1672-3266 55.4 µM 0.514131437794462 0.268435416266232 no 898 0.303580049490325 1495 6415873 SGTC_1738 st035555 74 µM 0.514086621509875 0.26845121279047 no 899 0.303595715274593 1467 5331140 SGTC_1941 st076221 61.8 µM 0.51253638305233 0.268997917325751 no 900 0.3041378318627 1449 2828568 SGTC_23 0213-0011 39.996 µM 0.511705227167531 0.269291261355745 no 901 0.304428663621147 1526 627608 SGTC_1004 4084-0029 199 µM 0.509996330753513 0.269894894353242 no 902 0.305027016205967 1527 716894 YLR208W SEC13 SGTC_2740 felodipine 17.08 µM 0.509081592304586 0.270218285238401 no 903 0.305347516963697 1542 3333 L-type calcium channel blocker SGTC_1143 3454-2408 5.08 µM 0.508701641104636 0.270352667735503 no 904 0.305480685956848 1442 X1143 SGTC_861 0443-0273 110 µM 0.508596172639365 0.270389976121558 no 905 0.30551765613575 1491 6149169 SGTC_830 4076-0286 57.8 µM 0.508551346057308 0.270405833843676 no 906 0.305533369933207 1505 6866659 SGTC_989 1501-0895 10.3 µM 0.507755860059271 0.270687319960094 no 907 0.305812284256935 1495 2830112 SGTC_276 colchicine 750 µM 0.506580419923494 0.271103522136437 no 908 0.306224624814113 1503 2833 A microtubule depolymerizer. SGTC_2511 berberine 10.47 µM 0.505607026729648 0.271448424534728 no 909 0.30656627388928 1466 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3194 9111903 49.47 µM 0.504386013631482 0.271881374943931 no 910 0.306995072289656 1524 17087251 SGTC_1880 MG-132 525 µM 0.503243519802506 0.272286794637925 no 911 0.307396535335155 1534 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2179 6298986 200 µM 0.503216472937518 0.272296395992827 no 912 0.307406042182896 1564 738374 SGTC_190 3970-0790 3.722 µM 0.502657542130626 0.272494848247193 no 913 0.307602532730358 1530 2832352 SGTC_2623 humulene 100 µM 0.502419879655083 0.272579253711247 no 914 0.307686099034989 1414 6187145 An anti-inflammatory. SGTC_1473 k844-0725 134 µM 0.500917341096328 0.273113178193834 no 915 0.308214648834148 1518 54682906 SGTC_557 1315-0110 16.2 µM 0.49949987675105 0.273617346369092 no 916 0.308713636790477 1431 6833801 SGTC_1226 3909-7979 35.4 µM 0.497889007027218 0.274190864069948 no 917 0.309281137968768 1554 6615510 SGTC_2566 crystal violet carbinol 226 nM 0.497316441896322 0.274394857276723 no 918 0.309482959483333 1385 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3264 9137442 49.47 µM 0.497058373378121 0.274486826279209 no 919 0.30957394396216 1558 17015726 SGTC_1445 4239-0156 97.7 µM 0.496709538011873 0.274611166430407 no 920 0.309696947695986 1637 4008346 SGTC_1792 st045773 43.6 µM 0.496519237377794 0.27467900959337 no 921 0.309764059077308 1475 2919270 SGTC_2969 9091408 28.7 µM 0.496261555480942 0.274770887697731 no 922 0.309854943227272 1417 4286311 SGTC_79 0052-0007 94.094 µM 0.493760397174828 0.275663477915558 no 923 0.310737702520787 1572 2801472 SGTC_846 0335-0850 148 µM 0.493030114042711 0.275924363203207 no 924 0.310995654727385 1483 6819598 SGTC_852 0418-0143 439 µM 0.492580281672047 0.27608512100456 no 925 0.311154591740948 1505 5369229 SGTC_2436 5633522 8.09 µM 0.492186845955612 0.2762257618687 no 926 0.311293631282726 1581 5724242 SGTC_2226 7298446 200 µM 0.491555892494891 0.276451381214761 no 927 0.311516665419023 1546 3283010 SGTC_3278 9139605 49.47 µM 0.491426911894312 0.276497513835244 no 928 0.311562266963087 1546 7958859 SGTC_522 1273-0010 11.6 µM 0.48997131852411 0.277018398877975 no 929 0.312077097349672 1533 5705015 SGTC_2856 9022925 19.48 µM 0.489787479542273 0.277084219925798 no 930 0.312142145698968 1510 4944862 SGTC_1555 citronellol 128 µM 0.489546793190045 0.277170405969797 no 931 0.312227317393563 1566 8842 A terpine precursor. SGTC_3060 1327-0027 12.5 µM 0.489531562213628 0.277175860387086 no 932 0.312232707517831 1512 16000455 YPR107C YTH1 SGTC_398 bronopol 33.3 µM 0.48924366742037 0.277278969256914 no 933 0.312334598807524 1523 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3012 9080433 71.4286 µM 0.488552419474779 0.27752661471584 no 934 0.312579302823956 1575 17688859 SGTC_465 cgp-37157 41 µM 0.488109114124105 0.277685489496752 no 935 0.31273627786264 1508 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1455 4262-0120 131 µM 0.488074590796267 0.277697864065634 no 936 0.312748504046908 1569 1529587 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.486669089389873 0.278201881663253 no 937 0.313246426894128 1578 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2373 9071805 200 µM 0.486598673241227 0.278227144863865 no 938 0.313271381984403 1618 10149009 SGTC_1271 0832-2808 169 µM 0.485517444005084 0.278615197853491 no 939 0.313654670904712 1600 3663794 SGTC_2804 7954240 19.48 µM 0.484972978269962 0.278810706243224 no 940 0.313847756774513 1588 828705 SGTC_730 1436-0052 41.2 µM 0.484150432186435 0.279106195126741 no 941 0.314139555985406 1509 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_115 0527-0192 112.043 µM 0.484126503941823 0.279114793313164 no 942 0.314148046299393 1512 4233931 SGTC_2213 7173844 200 µM 0.48375367596394 0.279248779006964 no 943 0.314280347293482 1479 892728 SGTC_788 1182-0090 188 µM 0.482271616907435 0.279781705404714 no 944 0.314806503659613 1666 5715185 SGTC_694 1315-0438 43.2 µM 0.482078035230017 0.279851350913834 no 945 0.314875256270549 1548 6793154 SGTC_2391 6285546 200 µM 0.481948041428609 0.27989812392503 no 946 0.314921428565856 1481 846083 SGTC_1015 4130-4525 82 µM 0.481759185723904 0.279966082765221 no 947 0.314988513082675 1468 1363237 SGTC_2669 eugenol 100 µM 0.481471524354716 0.280069611731691 no 948 0.315090706654311 1546 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2881 9058953 51.95 µM 0.48097497381849 0.280248363296161 no 949 0.315267142761944 1434 17122249 SGTC_1948 st076329 66.6 µM 0.480145192011498 0.280547196953042 no 950 0.315562077832167 1430 24208413 SGTC_1568 digitonin 820 nM 0.47970922883763 0.280704264417753 no 951 0.315717082335959 1664 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_442 cape 100 µM 0.479044039423951 0.28094399873114 no 952 0.315953649534844 1626 5281787 SGTC_2397 5161689 200 µM 0.478899823125283 0.280995987345348 no 953 0.316004948401391 1589 2259942 SGTC_1835 st008666 49.2 µM 0.478267333513518 0.281224048766684 no 954 0.316229971741267 1450 690455 SGTC_3149 9097855 49.47 µM 0.475896369465475 0.28207975927396 no 955 0.317074104401078 1637 25236625 YMR079W SEC14 SGTC_1114 scopoletin 1.73284 µM 0.474354891389271 0.282636769646142 no 956 0.317623427193267 1612 5280460 A coumarin with genotoxic properties. SGTC_2045 5106652 78.05 µM 0.47110094657582 0.283814309606023 no 957 0.318784324597738 1580 673349 SGTC_373 0844-0104 25.9 µM 0.469522652043512 0.284386308664789 no 958 0.319348048684982 1621 5375804 SGTC_2161 5662504 8.5105 µM 0.468764079712104 0.284661423216817 no 959 0.319619138952146 1508 2859334 SGTC_1192 1488-0095 21.4 µM 0.46841775539578 0.284787068314948 no 960 0.31974293660555 1532 915875 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.468005534086349 0.284936655070675 no 961 0.319890316084966 1564 688788 SGTC_1136 pergolide 1.05886 µM 0.46750413690395 0.285118652440296 no 962 0.320069616506533 1535 47811 A dopamine receptor agonist. SGTC_551 k048-0028 34.9 µM 0.466133246386985 0.285616541550845 no 963 0.320560063585003 1605 6836383 SGTC_440 fluspirilene 35.1 µM 0.465276794811883 0.285927803153205 no 964 0.320866625161652 1616 3396 An atypical antipsychotic. SGTC_2186 6124449 200 µM 0.463723283013113 0.28649280966386 no 965 0.321423006861163 1569 3834182 YLR033W RSC58 SGTC_2753 fluvastatin 17.09 µM 0.46288379315967 0.286798349341927 no 966 0.321723832477621 1558 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1070 indatraline 8.81 µM 0.462488261647756 0.286942360004745 no 967 0.321865609100667 1506 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_759 3486-0358 89.3 µM 0.460031473295476 0.287837628342571 no 968 0.322746814871942 1693 875103 SGTC_878 0828-0289 13.7 µM 0.459500246954594 0.288031383728258 no 969 0.322937487376183 1529 745350 YLR208W SEC13 SGTC_2183 6420625 130.508 µM 0.459354841506126 0.288084428515774 no 970 0.322989685714876 1517 2897619 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.458406699747972 0.288430429355528 no 971 0.32333013959925 1500 390807 SGTC_2695 st077686 51.995 µM 0.457700118664862 0.288688405924448 no 972 0.323583951374598 1497 2876092 SGTC_1359 1582-0056 520 nM 0.457637412292542 0.288711305608306 no 973 0.323606480167859 1587 3661189 SGTC_3319 9138450 16.7555 µM 0.45703168883151 0.288932553242739 no 974 0.323824134365959 1520 2029690 SGTC_2524 avocatin b 10.57 µM 0.456281720042105 0.289206598673353 no 975 0.324093703630047 1607 6710748 SGTC_2778 tioconazole 65.09 nM 0.455280536546234 0.289572630574703 no 976 0.324453713443376 1495 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1754 st042065 16.137 µM 0.454195269602846 0.289969648824181 no 977 0.324844143723806 1488 1126236 YIL048W NEO1 SGTC_3327 9140648 26.9345 µM 0.453536822182292 0.290210649968644 no 978 0.325081117368077 1630 8029710 SGTC_2570 licareol 100 µM 0.453233427154159 0.290321728446825 no 979 0.325190332334352 1516 443158 SGTC_156 3474-0145 5.642 µM 0.45229423372056 0.29066571052336 no 980 0.325528514719868 1663 2265471 SGTC_967 1306-0166 352 µM 0.452263791541783 0.290676863240769 no 981 0.325539478667704 1657 4437607 SGTC_2439 5492030 7.2 µM 0.451879499652015 0.290817668625864 no 982 0.325677896858227 1603 5722370 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.451479435999713 0.290964286687012 no 983 0.325822021422577 1576 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_292 k038-0015 474 µM 0.451197619453574 0.29106758947127 no 984 0.325923562614153 1573 46368540 SGTC_1493 4348-0038 111 µM 0.450564705097702 0.291299653226307 no 985 0.326151654751036 1603 800424 SGTC_2295 7971645 200 µM 0.450468920785515 0.291334780929816 no 986 0.326186179543317 1614 2978226 YKL099C UTP11 SGTC_2906 7926292 26.41 µM 0.450152265716786 0.291450924300052 no 987 0.326300326272451 1522 2966319 SGTC_1556 plumbagin 1.48 µM 0.450015544733621 0.291501077766899 no 988 0.326349616011927 1521 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3043 9092303 49.47 µM 0.449402246711221 0.291726103878608 no 989 0.326570755439581 1477 25236084 SGTC_503 tyrphostin 8 294 µM 0.449268578117405 0.291775159168724 no 990 0.32661896097542 1621 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_685 1278-0033 54.9 µM 0.444891816826125 0.293383514119652 no 991 0.328198968321332 1638 3590572 SGTC_209 4077-0173 175.592 µM 0.444574473191403 0.293500289852821 no 992 0.328313649152219 1562 15993494 SGTC_262 fenpropimorph 62.5 µM 0.444521248070184 0.293519877677477 no 993 0.328332885095114 1524 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3047 9092122 49.47 µM 0.444449558895176 0.293546261570742 no 994 0.328358794799615 1510 17173831 SGTC_435 c-PAF 6.7 µM 0.443375622848732 0.2939416355304 no 995 0.328747032569248 1556 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1053 3366-3204 134 µM 0.443147675656005 0.294025586894949 no 996 0.328829461379228 1527 3632071 YPR165W RHO1 SGTC_1275 0867-0008 21.1 µM 0.442367579896548 0.294312974575089 no 997 0.32911161762164 1582 3422836 SGTC_1665 st014639 11.4 µM 0.440875031319474 0.294863191472358 no 998 0.329651735330667 1633 981133 YIL048W NEO1 SGTC_2050 5263056 171 µM 0.439870231410823 0.295233870282469 no 999 0.330015548734898 1673 763468 YGL055W OLE1 SGTC_2682 pyrogallin 40.03 µM 0.439678247094158 0.29530471924932 no 1000 0.330085079857493 1589 822798 An ATP competetive kinase inhibitor. SGTC_271 rotenone 740 µM 0.438600603778182 0.295702552688351 no 1001 0.330475479731282 1604 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2636 apigenin dimethyl ether 100 µM 0.437887366190269 0.295965993889591 no 1002 0.330733967180977 1587 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_293 4049-0273 38.5 µM 0.437695498584032 0.296036880433635 no 1003 0.33080351651757 1555 1380311 SGTC_2584 androsterone 48.74 µM 0.435891462588073 0.296703772238306 no 1004 0.331457739822848 1588 2754130 A steroid. SGTC_1509 1326-1131 80 µM 0.434977881015284 0.297041754994197 no 1005 0.331789241354744 1649 768313 SGTC_2194 5927483 104.545 µM 0.434527030952167 0.297208613444077 no 1006 0.33195288504451 1592 760979 SGTC_475 α-linolenic acid 10 µM 0.43287791689282 0.297819310950185 no 1007 0.332551731928355 1644 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_318 1488-0629 67.2 µM 0.43199114701371 0.298147934706652 no 1008 0.332873923766664 1535 3662576 SGTC_1062 mesoridazine 14.2 µM 0.431667514675575 0.298267909177073 no 1009 0.332991540497032 1582 4078 A neuroleptic. SGTC_501 nsc-95397 161 µM 0.43006819883703 0.298861117602008 no 1010 0.333573016114623 1650 262093 SGTC_2991 9074669 71.4286 µM 0.429943940607424 0.298907229136244 no 1011 0.333618210404708 1667 17333109 SGTC_2820 7989630 71.43 µM 0.429706029756483 0.298995525539622 no 1012 0.333704748327665 1651 2984098 SGTC_2532 xanthone 78.9 µM 0.428680664701371 0.299376207099854 no 1013 0.334077816789241 1653 7020 An insecticide. SGTC_3069 9117009 49.47 µM 0.425651548360841 0.300502091873599 no 1014 0.335180886184335 1566 41904981 SGTC_1248 0469-0687 58.6 µM 0.42519201882032 0.300673060200977 no 1015 0.335348350927534 1669 4017482 SGTC_97 0535-0701 19.132 µM 0.423396157353558 0.30134163251796 no 1016 0.336003124006696 1516 2832013 YGL099W LSG1 SGTC_186 3455-3465 67.277 µM 0.422911599768716 0.301522140647727 no 1017 0.336179879632729 1580 755278 SGTC_3105 9121040 49.47 µM 0.420235344870819 0.302519978341536 no 1018 0.337156768400884 1543 41448907 SGTC_1803 st050068 52.4 µM 0.419966999443613 0.302620112145015 no 1019 0.337254780803206 1618 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1861 st057647 17.4 µM 0.419530038882621 0.302783196904966 no 1020 0.337414403038173 1721 688668 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.419367252519198 0.302843962964458 no 1021 0.337473876581875 1650 5393153 SGTC_913 3487-1245 167 µM 0.418962910519262 0.302994922261936 no 1022 0.337621619368373 1507 4016153 SGTC_1507 4075-3230 155 µM 0.416827585962216 0.303792694066117 no 1023 0.338402261652632 1598 659771 SGTC_1096 rimcazole 32.2 µM 0.414507143620741 0.304660688034972 no 1024 0.339251368231518 1603 18528119 A dopamine reuptake inhibitor. SGTC_848 0368-0089 85.6 µM 0.414491196820211 0.304666656973347 no 1025 0.339257206386978 1667 762535 SGTC_1856 st057054 55.7 µM 0.414271363055541 0.304748946752937 no 1026 0.339337691898582 1720 1266018 SGTC_1282 0886-0010 32.4 µM 0.413834483167981 0.30491251214429 no 1027 0.339497664066423 1730 2836211 YNL267W PIK1 SGTC_1923 st058458 19.1 µM 0.413626831018541 0.304990269622592 no 1028 0.339573710130145 1724 3534982 SGTC_1998 st075797 76.8 µM 0.41199234334853 0.305602627533433 no 1029 0.340172517631252 1715 24208315 SGTC_255 tunicamycin 200.472 nM 0.411982434836598 0.305606341400831 no 1030 0.340176148924463 1707 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_353 1988-1175 58.3 µM 0.411565411838093 0.305762666363563 no 1031 0.340328993865676 1540 2788357 SGTC_2182 6325192 200 µM 0.411492666659129 0.305789939199865 no 1032 0.340355658710561 1610 736248 SGTC_358 0075-0058 9.45 µM 0.410718563124817 0.306080224424211 no 1033 0.340639456836899 1848 1069125 SGTC_2043 5101342 149 µM 0.409392321647588 0.306577841881826 no 1034 0.341125886802958 1610 678451 SGTC_3119 9125183 49.47 µM 0.409090654683385 0.306691079820132 no 1035 0.341236567096508 1615 22695334 SGTC_2531 methyl deoxycholate 70.07 µM 0.409019264864297 0.30671788040348 no 1036 0.341262761708906 1568 16667744 Haematoxylin. SGTC_2150 5556613 200 µM 0.408477522789049 0.306921290458711 no 1037 0.341461564601448 1631 743190 SGTC_2246 7293507 91.5585 µM 0.406815530973624 0.30754569592271 no 1038 0.342071739464152 1773 887656 SGTC_3277 9138724 49.47 µM 0.405827691147052 0.30791708899922 no 1039 0.34243460537441 1627 15943418 SGTC_2563 tomatine 8.54 µM 0.405144331688537 0.308174123365331 no 1040 0.342685710834978 1861 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1215 3852-0577 11.2 µM 0.404329958766252 0.308480559167891 no 1041 0.342985048952375 1726 2884876 SGTC_1408 3909-7976 48.8 µM 0.402977438295254 0.308989786311285 no 1042 0.343482411083638 1653 24152374 SGTC_366 0181-0206 4.31 µM 0.402936726523628 0.309005120088476 no 1043 0.343497386224364 1787 274874 SGTC_1360 1598-0022 39.8 µM 0.401382664619697 0.309590694241784 no 1044 0.344069205241339 1723 761525 SGTC_2998 9066762 71.4286 µM 0.399554690404759 0.310280098257112 no 1045 0.344742267217881 1712 4945196 SGTC_3116 9124943 49.47 µM 0.398536677417882 0.31066432211527 no 1046 0.345117313956995 1535 41905195 YPL160W CDC60 SGTC_155 k072-0202 43.6 µM 0.398260221494012 0.310768699264445 no 1047 0.345219189530675 1643 5857737 SGTC_655 k060-0012 42 µM 0.398040110725522 0.310851813943736 no 1048 0.345300309616715 1599 5994525 SGTC_646 4092-0839 27.3 µM 0.396737137676431 0.311344019172319 no 1049 0.345780655503123 1713 877796 SGTC_2794 7785382 27.27 µM 0.396619192073696 0.311388590440058 no 1050 0.345824148859848 1748 2205081 SGTC_1384 3089-0840 101 µM 0.395275195367071 0.31189667763905 no 1051 0.346319901644223 1740 1069836 SGTC_1404 3909-7820 48.3 µM 0.393005597384303 0.312755493775628 no 1052 0.347157673616644 1723 23741373 SGTC_1906 st060206 94.7 µM 0.391701108259324 0.313249573405563 no 1053 0.347639535535724 1740 5133468 SGTC_371 0195-0006 7.36 µM 0.391553996935809 0.31330531337444 no 1054 0.347693892079068 1553 3928593 SGTC_1971 st069429 63.5 µM 0.390876412236234 0.313562102909011 no 1055 0.347944295010263 1740 1246522 YGL099W LSG1 SGTC_1231 0242-0792 125 µM 0.390438924621193 0.313727949010168 no 1056 0.348106004774557 1603 3707635 SGTC_1058 3448-5425 97.3 µM 0.389968087556767 0.313906479535321 no 1057 0.348280072451171 1634 7279705 SGTC_3166 9102297 49.47 µM 0.389038511073975 0.314259081342624 no 1058 0.348623829142247 1599 25237072 SGTC_493 zm226600 134 µM 0.388608264745677 0.31442233742334 no 1059 0.348782976022015 1665 5240098 A potassium channel opener. YCR052W RSC6 SGTC_949 1165-0505 146 µM 0.387906383167924 0.314688742840864 no 1060 0.349042657104345 1620 6244267 SGTC_1573 oleylamine 1.06 µM 0.386973650366278 0.315042919199753 no 1061 0.349387857576262 1610 5356789 An amine of the fatty acid oleic acid. SGTC_2502 avocadyne acetate 18.59 µM 0.38614991686175 0.315355847938581 no 1062 0.349692821503187 1615 3952079 SGTC_1435 4092-0789 56.7 µM 0.38440209174756 0.316020269169569 no 1063 0.350340225205862 1746 2248285 SGTC_466 geldanamycin 89.2 µM 0.383407337470374 0.31639868246899 no 1064 0.350708881871598 1724 5288382 HSP90 inhibitor. SGTC_1355 1499-0035 1.68 µM 0.383225538665501 0.316467861134516 no 1065 0.350776271850618 1623 1548538 SGTC_1121 fusaric acid 630.51 nM 0.383064075843138 0.316529306871302 no 1066 0.350836127535219 1621 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1680 diphenhydramine 100 µM 0.383058683275337 0.316531359135772 no 1067 0.350838126671302 1643 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1714 st033236 13.627 µM 0.382510704792503 0.316739934267932 no 1068 0.351041295116933 1750 2916566 SGTC_2177 5811945 192 µM 0.381550302414075 0.317105629397957 no 1069 0.351397476506367 1726 5343475 SGTC_231 b-estradiol 524 µM 0.380846631352925 0.317373681667805 no 1070 0.351658527644028 1613 450 A steroid. SGTC_1145 3546-0597 10.2 µM 0.37983333394079 0.317759849459264 no 1071 0.352034568288879 1652 875334 SGTC_918 glabranin 770.725 nM 0.378711960597543 0.318187436183646 no 1072 0.352450885278304 1704 124049 Also referred to as licorice root. SGTC_984 1492-0255 2.91 µM 0.378494813755991 0.318270263674919 no 1073 0.352531522876257 1688 1585198 SGTC_1324 1418-0026 34.4 µM 0.378195460595859 0.318384462463188 no 1074 0.352642698701151 1693 1372513 SGTC_454 lyso-paf C-16 6.67 µM 0.377688775736027 0.318577794545002 no 1075 0.352830903470242 1559 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2117 5521686 200 µM 0.376952107346577 0.318858967899765 no 1076 0.35310459835703 1622 803312 SGTC_1862 st057513 3.81 µM 0.376311181734027 0.319103682771817 no 1077 0.353342783707817 1640 5393163 SGTC_2338 7999974 200 µM 0.375094736868242 0.319568356195308 no 1078 0.353795005566056 1843 315925 SGTC_1385 3091-4834 14.1 µM 0.373834154381474 0.320050188940201 no 1079 0.354263853641755 1723 4072814 SGTC_733 4069-0007 56.1 µM 0.373015674067349 0.320363199526043 no 1080 0.354568389153917 1709 5717425 YNL287W SEC21 SGTC_1343 1487-0095 224 µM 0.372483665776149 0.320566723481034 no 1081 0.354766385657647 1777 4560101 YGL055W OLE1 SGTC_3354 9151612 71.43 µM 0.372008264770842 0.320748637532124 no 1082 0.354943347937012 1774 27261949 SGTC_90 0870-0863 4.608 µM 0.372003815941125 0.320750340097584 no 1083 0.354945004107987 1641 1738164 SGTC_158 k038-0087 26.446 µM 0.370240358512899 0.321425511233377 no 1084 0.35560170402192 1697 X158 SGTC_1648 st011736 69.8 µM 0.369458453542384 0.321725066579714 no 1085 0.355893017626342 1739 2855514 SGTC_2083 5306046 65.942 µM 0.369174447127195 0.321833900891505 no 1086 0.355998850477138 1655 539837 SGTC_237 nikkomycin 200 µM 0.367999256090617 0.322284409149193 no 1087 0.356436894441749 1755 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1499 4480-0877 67.3 µM 0.367939209205619 0.322307435078511 no 1088 0.356459281576721 1688 2861909 SGTC_724 3910-0327 137 µM 0.36769202006608 0.322402230849974 no 1089 0.356551445714354 1625 2885483 SGTC_1374 2889-5571 141 µM 0.36648145899434 0.32286664151429 no 1090 0.357002922657156 1657 2853281 SGTC_863 0466-0191 129 µM 0.366454937485677 0.322876819125162 no 1091 0.357012816058936 1770 765160 YPR165W RHO1 SGTC_2249 haloperidol 116.36 µM 0.366271039662501 0.322947393437914 no 1092 0.357081418686756 1730 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2277 7947813 106.88 µM 0.365740105433285 0.323151185387983 no 1093 0.357279508309521 1784 1246798 SGTC_599 1935-0052 86.5 µM 0.363796624608781 0.323897616791015 no 1094 0.358004941683922 1676 9557311 SGTC_1321 1326-2144 215 µM 0.363528652468216 0.32400059233922 no 1095 0.358105006609276 1762 3513030 SGTC_2361 9034121 116 µM 0.36315271745901 0.324145078243301 no 1096 0.358245402962295 1667 6496917 SGTC_2605 digitonin 300 nM 0.362905043461757 0.324240283113376 no 1097 0.358337909547627 1802 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.361525906865797 0.324770627602351 no 1098 0.358853170924572 1743 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1824 st053723 68.6 µM 0.361457570104567 0.32479691563064 no 1099 0.358878709017599 1625 675225 SGTC_1172 0370-0043 85 µM 0.361113803101074 0.324929170377139 no 1100 0.359007187559502 1721 376585 SGTC_2469 5655019 90.81 µM 0.360791715286354 0.325053104685748 no 1101 0.359127578253888 1793 2788239 SGTC_3144 9087057 49.47 µM 0.358850280963715 0.325800547614375 no 1102 0.359853547806344 1851 17249618 SGTC_2080 5212524 12.4 µM 0.357440402895083 0.326343783356127 no 1103 0.360381067318802 1826 260183 SGTC_925 2064-1272 59.6 µM 0.35466684205889 0.327413530416863 no 1104 0.361419597151817 1660 6815817 SGTC_3129 9127257 49.47 µM 0.353518613820097 0.327856811467302 no 1105 0.361849838342566 1575 837894 SGTC_2252 omeprazole 400 µM 0.353364928489973 0.327916161124057 no 1106 0.36190743751063 1767 4594 A proton pump inhibitor. SGTC_876 0720-0963 56.8 µM 0.352387339492566 0.328293784679248 no 1107 0.362273897733353 1845 765861 SGTC_2710 st078562 53.7235 µM 0.351064066036158 0.328805218932324 no 1108 0.362770142732572 1643 17250908 SGTC_1704 st028805 70.8 µM 0.35100975560258 0.328826216324665 no 1109 0.362790514792806 1687 2876101 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.350946974932479 0.328850489136349 no 1110 0.36281406455648 1658 4174840 SGTC_938 3126-1755 342 µM 0.348494617659259 0.329799204923937 no 1111 0.363734377641981 1817 1777771 SGTC_568 1193-0097 7.48 µM 0.348346551019641 0.329856520939095 no 1112 0.363789968871943 1745 3646150 SGTC_3293 9120939 62.045 µM 0.347518542222627 0.330177113500648 no 1113 0.364100895416122 1760 934087 SGTC_3336 9143619 71.43 µM 0.347133066196334 0.330326406587945 no 1114 0.364245676503107 1784 45595730 SGTC_1406 3909-7906 11.9 µM 0.347015409840591 0.330371979733696 no 1115 0.364289870958567 1740 X1406 SGTC_236 1509-0011 5.31 µM 0.34433196748714 0.331412069255175 no 1116 0.365298322960387 1775 3107280 SGTC_3203 9113543 49.47 µM 0.343782666139362 0.331625136597242 no 1117 0.365504868502511 1759 17018012 SGTC_2921 7974240 10.71 µM 0.3436258443354 0.331685975877935 no 1118 0.365563843012265 1755 2979074 YDR527W RBA50 SGTC_2567 aureobasidin a 60 nM 0.342944389519626 0.331950398959387 no 1119 0.365820148248119 1749 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_604 1000-0114 314 µM 0.341426077417973 0.332539846439754 no 1120 0.366391423160968 1826 1572745 SGTC_2931 9014674 55.67 µM 0.340289251732362 0.332981462507551 no 1121 0.366819355294563 1656 2996810 SGTC_933 2914-0560 114 µM 0.340146913260989 0.333036772243414 no 1122 0.366872947043408 1871 463887 SGTC_2585 alliin 100 µM 0.340092462010516 0.333057931814565 no 1123 0.366893449128246 1807 87310 A garlic compound which reacts with lipids. SGTC_178 4092-0806 87.505 µM 0.33898493353654 0.333488428889038 no 1124 0.367310540105827 1699 2169044 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.337632009210053 0.334014609150001 no 1125 0.367820258693626 1948 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1851 st056236 18.9 µM 0.334698185471422 0.335156754352625 no 1126 0.368926385184918 1850 5393171 SGTC_2948 9070189 9.45 µM 0.333375235530307 0.335672281999718 no 1127 0.369425527105861 1855 6473636 YDL196W YDL196W SGTC_956 1185-0240 191 µM 0.332928823471458 0.335846309899415 no 1128 0.369594005707129 1742 1416193 SGTC_153 4077-0274 519.67 µM 0.332708698325545 0.335932135769055 no 1129 0.369677091484037 1859 3121976 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.331228473845759 0.336509491097785 no 1130 0.370235956989235 1816 6710655 SGTC_3024 9090631 49.47 µM 0.330998634156667 0.336599173726111 no 1131 0.370322758622159 1877 25236383 SGTC_2848 9016370 25.97 µM 0.330471065691166 0.336805064209684 no 1132 0.370522025961183 1890 7894410 SGTC_124 0136-0217 7.121 µM 0.328644688299667 0.3375182093088 no 1133 0.371212133102063 1888 3976905 SGTC_2116 5511452 16.8835 µM 0.328023743890114 0.337760802457625 no 1134 0.37144685498444 1764 870744 SGTC_1854 st056233 32.9 µM 0.326709297368011 0.338274558211172 no 1135 0.371943883770161 1867 5393174 SGTC_595 3909-8003 73.7 µM 0.326215171965645 0.338467766713691 no 1136 0.372130781580422 1769 699517 SGTC_2626 ethyl orsellinate 100 µM 0.325828184495465 0.338619112798949 no 1137 0.372277176618727 1702 75653 A natural product. SGTC_268 camptothecin 39.6153 µM 0.323912727039719 0.339368608259576 no 1138 0.373002054120069 1738 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_29 0299-0004 12.984 µM 0.323630609753725 0.339479051155682 no 1139 0.373108855442574 1765 16871 A napthoquinone isolated from Swertia calycina. SGTC_2174 5790901 200 µM 0.323600833942717 0.339490708554727 no 1140 0.373120128259566 1746 786020 SGTC_1802 st050112 57.9 µM 0.323248175622565 0.339628787967689 no 1141 0.373253649345657 1759 4662563 SGTC_512 prima-1 270 µM 0.323081072188034 0.339694222962676 no 1142 0.373316922223537 1814 322968 A re-activator of the apoptotic function of mutant p53. SGTC_233 rapamycin 362 pM 0.322925781793123 0.339755036494357 no 1143 0.373375725215574 1779 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2055 5235184 200 µM 0.322682031785313 0.339850500254964 no 1144 0.373468030687638 1753 2836034 SGTC_443 clozapine 122 µM 0.3208959213413 0.340550336649695 no 1145 0.374144632458199 1862 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2340 7987427 183.45 µM 0.319638556804829 0.341043328699949 no 1146 0.374621171201162 1786 2239331 SGTC_1787 fluconazole 80 µM 0.318749859899886 0.341391936032715 no 1147 0.374958101204643 1751 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2369 9071472 200 µM 0.318682641926793 0.341418309001243 no 1148 0.374983589315712 1786 17296037 SGTC_1207 2099-0101 141 µM 0.318086152052051 0.341652375689072 no 1149 0.375209793804608 1872 5837381 SGTC_308 4092-1169 104 µM 0.316948829573367 0.342098837472864 no 1150 0.375641214979035 1756 2268590 YDL196W YDL196W SGTC_3180 9109287 49.47 µM 0.316757019146425 0.342174155421808 no 1151 0.375713989878062 1757 18891271 SGTC_139 0099-0334 718.624 µM 0.31656155261971 0.342250915466615 no 1152 0.375788156488857 1847 97690 SGTC_2916 7875993 68.79 µM 0.315875989695738 0.342520188721488 no 1153 0.376048318506353 1916 1299250 SGTC_669 0108-0021 26.2 µM 0.315534888740366 0.342654195119153 no 1154 0.376177782783447 1994 17201 SGTC_2076 5212012 200 µM 0.315459304749763 0.342683892053807 no 1155 0.376206472442721 1762 604802 SGTC_49 0717-0965 32.132 µM 0.313946983525276 0.343278286887336 no 1156 0.376780652669346 1832 5889349 YGL099W LSG1 SGTC_2997 9067075 71.4286 µM 0.313850119021083 0.343316371239352 no 1157 0.376817438342547 1808 27209819 SGTC_1983 st071813 46.9 µM 0.31354514519219 0.343436288613967 no 1158 0.376933263793782 1770 11838595 SGTC_3322 9139058 2.11 µM 0.313226002992214 0.343561793946697 no 1159 0.37705448208445 1821 4908926 YPR165W RHO1 SGTC_2741 miltefosine 3.04 µM 0.312260612199023 0.343941546881869 no 1160 0.377421235683354 1787 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1539 benzyladenosine 56 µM 0.312222356114497 0.343956598811601 no 1161 0.377435771514499 1758 92208 A nucleotide analog. SGTC_1717 st033143 58.0435 µM 0.312195778345164 0.343967056031432 no 1162 0.377445870140176 1870 674616 SGTC_577 r071-0003 38.6 µM 0.311732808391646 0.344149234123064 no 1163 0.377621796017601 1716 4568517 YMR134W ERG29 SGTC_315 k915-0449 187 µM 0.31131775104439 0.344312589420981 no 1164 0.37777953697181 1815 20970215 YNL149C PGA2 SGTC_619 1652-1634 108 µM 0.311228398754888 0.344347759856068 no 1165 0.377813497634265 1751 5400454 SGTC_742 0kpi-0133 140 µM 0.311086051962552 0.34440379252249 no 1166 0.377867602187002 1886 2728852 SGTC_3307 9126885 69.2785 µM 0.310450667510964 0.344653943649705 no 1167 0.378109134488111 1689 24824909 SGTC_1513 0337-0559 19 µM 0.310330298126666 0.344701340785243 no 1168 0.378154896556994 1688 775073 SGTC_2687 chenodiol 100 µM 0.31015053599458 0.344772129187992 no 1169 0.378223241761231 1784 5702181 A cholesterol synthesis inhibitor. SGTC_2274 7947094 46.08 µM 0.309944704173567 0.344853190229235 no 1170 0.37830150328869 1717 2971028 SGTC_3195 9113082 49.47 µM 0.309818154047317 0.344903031953077 no 1171 0.378349622750214 1907 17018038 SGTC_2493 resveratrol 26.09 µM 0.308651359731782 0.345362700202723 no 1172 0.378793373803416 1720 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_528 3492-0019 172 µM 0.308200537042118 0.345540366673465 no 1173 0.378964871920803 1768 2869262 SGTC_1545 lovastatin 49.4 µM 0.307999872442741 0.34561945831481 no 1174 0.379041214699962 1797 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2337 9009472 200 µM 0.307738667514392 0.345722421928762 no 1175 0.379140597095017 1862 5742383 SGTC_2375 9072683 200 µM 0.306237527427977 0.346314373044827 no 1176 0.379711900651958 1930 16798029 SGTC_136 0097-0015 404.482 µM 0.305513319150586 0.346600087662043 no 1177 0.37998761368423 1885 4861337 SGTC_1658 st012944 20 µM 0.3051660809765 0.34673711101911 no 1178 0.380119832232365 1840 24207260 SGTC_1301 naphtanilide LB 4.81 µM 0.302427452550191 0.347818500221104 no 1179 0.381163114913338 1870 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2825 7998094 58.44 µM 0.301773862950489 0.348076763525188 no 1180 0.381412228428808 1773 2987815 SGTC_372 0155-0182 15.9 µM 0.301009462630911 0.348378902654352 no 1181 0.381703639418917 1838 771486 SGTC_2629 bisabolol 100 µM 0.300096941588518 0.348739714422288 no 1182 0.382051606008051 1821 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_953 1188-0045 9.7 µM 0.297016596850641 0.349958694964215 no 1183 0.383226919076173 1829 6144426 SGTC_2663 amphotericin b 100 µM 0.29651957811231 0.350155524854257 no 1184 0.383416658852818 1802 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2852 9023854 51.95 µM 0.295763604947989 0.35045498332565 no 1185 0.383705309580525 1843 19798528 SGTC_1643 st009866 20.2 µM 0.293901523847729 0.351192992964878 no 1186 0.384416576822338 1878 3156273 YOR207C RET1 SGTC_2831 7999036 19.48 µM 0.293835688955155 0.351219095991613 no 1187 0.384441731203126 1935 2988270 SGTC_2716 st080858 38.6235 µM 0.292814942855468 0.351623903680169 no 1188 0.384831802941129 1878 5296050 SGTC_1152 3909-8331 15.9 µM 0.292404476077258 0.3517867341506 no 1189 0.384988693146977 1789 16001939 SGTC_882 0843-0131 351 µM 0.291775525377618 0.352036289031534 no 1190 0.385229129651958 1922 5425421 SGTC_2858 9025781 8.96 µM 0.289252932395794 0.353037842341768 no 1191 0.386193913976007 1907 4894980 YPL153C RAD53 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.289167240232248 0.353071882915033 no 1192 0.386226699976512 1886 688662 SGTC_2696 st077691 74.316 µM 0.287600702614524 0.353694385289635 no 1193 0.386826203492628 1813 757133 SGTC_2002 4023503 131 µM 0.286399412975162 0.354172012645036 no 1194 0.387286112129012 1985 4736863 YCR052W RSC6 SGTC_468 gf-109203x 121 µM 0.286213008954948 0.35424614663274 no 1195 0.387357490315546 1899 2396 A protein kinase C inhibitor. SGTC_18 0111-0177 500 nM 0.286055973064607 0.354308605027608 no 1196 0.387417625756803 1816 721752 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.28496935649113 0.3547408958632 no 1197 0.387833809464297 1907 94937 An inhibitor of serotonin biosynthesis. SGTC_1364 1653-0028 37.6 µM 0.283350376227823 0.355385324972214 no 1198 0.388454132094825 1807 5718652 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.283126890872963 0.355474315028814 no 1199 0.388539784327227 1812 521171 SGTC_1047 2043-3044 82 µM 0.282603752698688 0.355682655212377 no 1200 0.388740301659025 1748 669592 SGTC_451 chloral hydrate 100 µM 0.279807682353753 0.356796922161373 no 1201 0.389812528689309 1846 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1529 apigenin 74 µM 0.279408040887808 0.356956284103093 no 1202 0.389965850491141 1925 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1370 2001-0092 44.6 µM 0.279192166556889 0.357042377029255 no 1203 0.390048677452454 1938 790957 SGTC_127 0180-0333 59.125 µM 0.278900455363798 0.357158726048833 no 1204 0.390160609535922 1908 771601 SGTC_3065 9113888 49.47 µM 0.278601448334488 0.357277998799092 no 1205 0.390275350545652 1886 16648368 SGTC_3219 9131112 49.47 µM 0.278380525373352 0.357366133075056 no 1206 0.390360133702301 1873 17612988 YMR079W SEC14 SGTC_1897 st060201 15 µM 0.278372450653213 0.357369354521383 no 1207 0.390363232620068 1761 611878 SGTC_2908 7930301 100 µM 0.278299025005092 0.357398648484101 no 1208 0.390391412250142 1781 2223178 SGTC_280 3448-3607 3.04 µM 0.276004031669152 0.358314683903416 no 1209 0.391272484823029 1933 626179 SGTC_2649 anisomycin 9.56 µM 0.274215680949197 0.359029061419886 no 1210 0.391959439086482 1829 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2738 aclarubicin 5.55 µM 0.272771691011827 0.359606240094055 no 1211 0.392514360962067 1891 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_329 k048-0121 21.3 µM 0.271124476429758 0.360265041073275 no 1212 0.393147648452473 1808 6832902 SGTC_3006 9075424 71.4286 µM 0.270258306460615 0.360611631116525 no 1213 0.393480769417263 1782 7465181 SGTC_1567 st069303 68.4 µM 0.269631373464546 0.360862564130254 no 1214 0.393721930719598 1827 5581319 SGTC_754 3474-0146 171 µM 0.269400635408796 0.360954933258623 no 1215 0.393810698622933 1712 24762078 SGTC_361 000s-0510 1.45 µM 0.267197040107049 0.361837485063716 no 1216 0.394658727492385 1822 660 SGTC_2970 9090938 41.86 µM 0.265460684979104 0.362533422913027 no 1217 0.395327296259916 1986 17217104 SGTC_1012 4112-3522 18 µM 0.265286370652731 0.362603313908375 no 1218 0.395394431564466 1937 3112398 SGTC_246 cycloheximide 667 µM 0.264488425655199 0.36292330684493 no 1219 0.395701791179016 1821 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2935 9038016 29.96 µM 0.264223666859382 0.363029501923086 no 1220 0.395803787690496 1971 6463195 SGTC_1112 tnp00069 1.16933 µM 0.2635685795197 0.363292303514033 no 1221 0.396056186253674 1940 145826 SGTC_2058 5236698 133 µM 0.263283306049503 0.363406766885406 no 1222 0.396166112880538 1823 766665 SGTC_786 4544-0069 423 µM 0.262719379112771 0.363633073290191 no 1223 0.396383439482382 1890 748821 YLR208W SEC13 SGTC_2211 7117706 200 µM 0.262200058202384 0.363841521191397 no 1224 0.396583604261095 1931 822771 SGTC_764 1951-2361 146 µM 0.261200966962926 0.364242655266267 no 1225 0.396968766233814 1766 5438930 SGTC_1662 st014054 52 µM 0.261188126020342 0.364247811860286 no 1226 0.396973717230351 1927 2838777 SGTC_3173 9105693 49.47 µM 0.260182551237278 0.364651701209282 no 1227 0.397361481493235 1901 17096658 SGTC_2610 ononetin 44.17 µM 0.259652554625663 0.364864634978767 no 1228 0.397565896750985 1794 259632 SGTC_478 N-arachidonylglycine 10 µM 0.258648357460828 0.36526819992228 no 1229 0.397953284299174 1946 5283389 SGTC_840 0245-0196 390 µM 0.258311147950931 0.365403750565525 no 1230 0.398083391664844 1922 3827528 SGTC_2723 salbutamol 83.58 µM 0.257583329998384 0.365696374311992 no 1231 0.398364248205891 1935 9884233 β2-adrenoceptor agonist SGTC_2828 7998861 71.43 µM 0.254400799584561 0.366976846704814 no 1232 0.399592966651159 1989 2988188 SGTC_26 0302-0163 425.158 µM 0.252326103288724 0.36781238712573 no 1233 0.400394506619874 1883 3100915 SGTC_1903 st060211 78.3 µM 0.252053037569803 0.367922405314276 no 1234 0.400500034392829 1976 688960 SGTC_2491 paeonol 100 µM 0.251687020269307 0.368069890693817 no 1235 0.40064149521551 1842 11092 Increases levels of cortical cytochrome oxidase. SGTC_3179 9107801 49.47 µM 0.251467370809332 0.368158407007546 no 1236 0.40072639307103 1820 4818259 SGTC_1230 0170-0365 3.77 µM 0.251377503412082 0.368194624597118 no 1237 0.400761129538314 1972 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2468 5987765 72.9 µM 0.24962135089221 0.368902608907564 no 1238 0.401440092781059 1900 26772094 SGTC_2888 9058547 12.99 µM 0.249598484629791 0.368911830270007 no 1239 0.401448935297299 1827 16476514 SGTC_1724 st037281 8.293 µM 0.249551282189701 0.368930866011727 no 1240 0.401467188914142 1802 574124 YDL195W SEC31 SGTC_3270 9137563 49.47 µM 0.249470812003014 0.368963318670432 no 1241 0.401498307969666 1940 17015724 SGTC_705 1124-0212 310 µM 0.249404080653867 0.368990231329734 no 1242 0.401524114479816 1989 9554485 SGTC_3117 9124945 49.47 µM 0.249334028867586 0.369018483807712 no 1243 0.401551205539606 1765 17592065 SGTC_3124 9127567 49.47 µM 0.248869970227725 0.36920566044811 no 1244 0.401730682434169 1965 17592030 SGTC_3240 9133527 49.47 µM 0.248831353997933 0.369221237585299 no 1245 0.401745618380153 1869 17617455 SGTC_1450 4112-4260 37.6 µM 0.247876920244496 0.369606308283698 no 1246 0.4021148188513 1970 1633175 SGTC_3250 9135583 49.47 µM 0.24643928224902 0.370186576789108 no 1247 0.402671100421536 1981 7699353 SGTC_1279 0874-0590 65.2 µM 0.244875359587722 0.370818152760804 no 1248 0.403276470567196 1914 3523074 SGTC_1490 4089-0339 670 nM 0.244746184415216 0.370870334573175 no 1249 0.403326482654321 1973 742542 SGTC_3205 9113483 49.47 µM 0.244405874207777 0.371007818204659 no 1250 0.403458246374723 1974 17018033 SGTC_2876 9059903 25.97 µM 0.243227514113061 0.371483996946359 no 1251 0.403914576781237 1930 6916095 SGTC_330 1488-0319 80.1 µM 0.242989161946283 0.371580339696956 no 1252 0.404006896698347 1878 6846614 SGTC_3216 9129716 49.47 µM 0.242225380455117 0.371889116919898 no 1253 0.404302764885607 1834 8056934 SGTC_1974 st069448 26.9 µM 0.242149527768462 0.371919786713509 no 1254 0.404332151145394 1991 6323587 YNR016C ACC1 SGTC_2479 5617353 43.85 µM 0.24175299379046 0.372080131969883 no 1255 0.404485782047577 1940 2731746 SGTC_1196 1588-0294 184 µM 0.241732977125328 0.372088226637215 no 1256 0.404493537582829 1839 6144269 SGTC_2693 st077581 40.7 µM 0.240975101685293 0.37239475029576 no 1257 0.404787206970573 2002 25238761 SGTC_2256 7954252 200 µM 0.240716249134856 0.372499462063351 no 1258 0.404887522121608 1864 2972920 SGTC_2878 9043973 25.97 µM 0.240310291346452 0.372663700237996 no 1259 0.405044858701009 1973 6465167 SGTC_2819 7996655 46.38 µM 0.238300258755518 0.373477238900653 no 1260 0.405824110335432 1957 6456960 SGTC_2347 9049783 174.81 µM 0.237858726299402 0.373656020031059 no 1261 0.405995334237249 1952 6467988 YPL169C MEX67 SGTC_2862 9027634 71.43 µM 0.236751202219169 0.374104587737889 no 1262 0.40642490515298 1784 5012562 SGTC_3289 9119912 71.43 µM 0.236632717522103 0.374152586335864 no 1263 0.406470868015683 1898 17014829 SGTC_1026 k007-1105 30.6 µM 0.236465057096295 0.374220509540647 no 1264 0.406535909444713 1865 7066794 SGTC_1752 st044819 83.042 µM 0.235091646030745 0.374777057674117 no 1265 0.407068801259932 1843 441209 YML126C ERG13 SGTC_1975 st070967 30.8 µM 0.234603459495863 0.374974948691331 no 1266 0.407258262098649 2018 261391 SGTC_1522 st012842 45.6 µM 0.234580129723724 0.374984406459126 no 1267 0.407267316718704 1779 3491067 YOR116C RPO31 SGTC_2400 5203494 178.7 µM 0.232771587703223 0.375717808337007 no 1268 0.407969388337996 1894 6777674 SGTC_1895 st058434 18.3 µM 0.231846460802558 0.376093140633635 no 1269 0.408328634775955 2023 5393175 SGTC_3168 9103419 49.47 µM 0.231596258108484 0.376194670269709 no 1270 0.408425807051112 2006 16649256 SGTC_273 hydroxyurea 18.1 mM 0.231452126009608 0.376253161457965 no 1271 0.408481786798559 1895 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_691 1548-0686 185 µM 0.229276325878448 0.377136481706885 no 1272 0.409327076316942 1830 46495133 SGTC_1220 1838-0075 193 µM 0.22924567369613 0.37714893032961 no 1273 0.409338987587109 1943 5529645 SGTC_2445 5742597 35.57 µM 0.227144243664043 0.37800267773812 no 1274 0.410155790785346 1872 1774255 SGTC_536 3852-0578 10.6 µM 0.224589902507915 0.379041231659924 no 1275 0.411149160431116 2026 2869208 SGTC_2746 daunorubicin 9.88 µM 0.223050007902083 0.37966775064321 no 1276 0.411748293030814 2016 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2653 dihydrofissinolide 100 µM 0.221843521144564 0.380158840762769 no 1277 0.412217849251186 1957 6857746 SGTC_1612 st002233 45.4 µM 0.22110013416173 0.380461526359644 no 1278 0.412507232898486 2019 1035021 SGTC_1329 1447-1697 50.6 µM 0.218587273070648 0.381485231378722 no 1279 0.413485783842917 1937 2840515 SGTC_1574 spiramycin 23.7 µM 0.216271910067867 0.382429213043249 no 1280 0.414387901723223 1933 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1840 st055363 71 µM 0.216251839220632 0.382437399062818 no 1281 0.414395723762076 1842 676033 SGTC_795 0685-0265 78 µM 0.216123689572591 0.382489666930276 no 1282 0.414445667223682 1968 302754 SGTC_1893 st059353 36.1 µM 0.215176412631895 0.382876095203826 no 1283 0.414814890095111 1887 3112488 SGTC_2809 7964133 12.99 µM 0.214985489207496 0.382953993855393 no 1284 0.414889315994096 1926 1253665 SGTC_2954 9074818 52.69 µM 0.214540446446748 0.383135594092216 no 1285 0.415062814721041 1958 16648742 SGTC_2802 7925815 54.55 µM 0.213955142451833 0.383374467194396 no 1286 0.415291019129616 1892 1262923 SGTC_999 SEC7.066 22.7 µM 0.212811516856826 0.383841329285302 no 1287 0.415736990176841 1950 740511 YDR170C SEC7 SGTC_2004 4023728 41.89 µM 0.211728920648563 0.384283432763268 no 1288 0.416159262080998 2061 360084 YDR527W RBA50 SGTC_3073 9114972 49.47 µM 0.210610460408006 0.384740340309615 no 1289 0.416595624585868 2063 41905075 SGTC_3181 9108277 49.47 µM 0.210352941793974 0.384845563173045 no 1290 0.416696108956157 1904 17097298 SGTC_1797 st048695 56.8 µM 0.20977062729181 0.3850835298561 no 1291 0.416923349508906 2039 592262 YIL048W NEO1 SGTC_444 curcumin 90.4 µM 0.207916995577994 0.385841316541918 no 1292 0.417646889300544 1997 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_932 2857-0803 154 µM 0.207850151241838 0.38586865146054 no 1293 0.417672986297587 2037 674898 SGTC_2739 tacrine 100.86 µM 0.206915764777209 0.38625081308179 no 1294 0.418037822215552 1962 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2282 7944268 200 µM 0.206712406104193 0.386334000885907 no 1295 0.418117233995102 2008 2970414 SGTC_2986 9022445 71.43 µM 0.205644780725157 0.386770819364142 no 1296 0.418534197543649 2049 6459286 SGTC_1202 1988-0068 29.6 µM 0.204354631091768 0.387298874968066 no 1297 0.419038190577449 1860 2850480 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.202328299725355 0.388128669034945 no 1298 0.419830038736772 1929 6708760 SGTC_1113 artemisinin 1.17947 µM 0.202324397384325 0.388130267559686 no 1299 0.419831564004766 2070 2240 An anti-malaria and mitochondrial poison. SGTC_2966 9084041 48.03 µM 0.202080225443178 0.388230292030042 no 1300 0.419927003379943 1753 17741380 SGTC_2137 5261020 140 µM 0.199927009153607 0.389112672359536 no 1301 0.420768833306416 1945 763655 SGTC_1939 st074455 53.6 µM 0.198950505605768 0.389513028886785 no 1302 0.421150730674741 2082 1644229 SGTC_641 4092-0595 30 µM 0.198054961788367 0.389880295867869 no 1303 0.42150103102077 2011 786260 SGTC_462 ag-879 158 µM 0.196917719219207 0.39034682640559 no 1304 0.421945963616334 2063 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_875 0709-0210 25.7 µM 0.195873468240738 0.39077534816339 no 1305 0.422354602135439 2103 6251364 SGTC_1032 k061-1018 98.7 µM 0.195442469069437 0.39095225290205 no 1306 0.422523286045064 2103 4005393 SGTC_374 0880-0231 82.3 µM 0.19492991945756 0.391162659606909 no 1307 0.422723905557474 2028 6833587 SGTC_157 1348-1695 65.819 µM 0.194032463733779 0.391531150784304 no 1308 0.423075231271679 1979 5380510 SGTC_1433 4060-0023 7.6 µM 0.193621294164014 0.391700007650864 no 1309 0.423236211690994 2027 3840627 SGTC_343 4130-2827 29.8 µM 0.192427196392978 0.392190508755365 no 1310 0.423703795407696 1906 1118244 SGTC_1309 pyrazolanthrone 13.4 µM 0.192105007025838 0.392322884290517 no 1311 0.423829976460817 2071 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1760 st045453 10.4495 µM 0.191852503372333 0.392426637288257 no 1312 0.423928871518148 2093 3323419 YIL048W NEO1 SGTC_2860 9025725 38.96 µM 0.190251265581099 0.393084758823933 no 1313 0.424556120261137 1862 40546248 SGTC_2909 7941780 10.49 µM 0.189146340854329 0.393539070092166 no 1314 0.42498906110129 2098 1243215 SGTC_1744 st037937 38.9 µM 0.189131026274376 0.393545367999279 no 1315 0.424995062424973 2020 1016152 SGTC_302 1094-0063 18.9 µM 0.18862086396449 0.393755181031153 no 1316 0.425194989629871 1957 5440289 SGTC_1873 rapamycin 2 nM 0.188452432582851 0.393824458112561 no 1317 0.425261000331053 1956 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2328 6201408 200 µM 0.188121426308301 0.39396061324703 no 1318 0.425390732593882 1942 2890418 SGTC_3217 9129673 49.47 µM 0.18796175247973 0.394026297639383 no 1319 0.425453316916491 1974 17248312 SGTC_1955 wogonin 32.4 µM 0.187585402064956 0.394181127346436 no 1320 0.425600835280018 2050 5281703 A flavanone. SGTC_2089 5281248 129.67 µM 0.186966517027303 0.394435771599226 no 1321 0.425843442763158 1947 2737878 SGTC_909 3448-9333 149 µM 0.186825908595899 0.394493632141921 no 1322 0.425898566218574 1915 3344074 SGTC_2062 5245942 200 µM 0.185958676908184 0.394850550458259 no 1323 0.426238583540594 2086 1376160 SGTC_2462 5162487 171.77 µM 0.184540183898677 0.395434536297587 no 1324 0.426794853122479 2102 2259986 SGTC_841 0251-0215 91.2 µM 0.184295792170475 0.395535174796452 no 1325 0.426890707376314 2020 3888614 SGTC_893 0958-0369 48.9 µM 0.182635460459633 0.39621906980885 no 1326 0.42754202942933 2112 6819948 SGTC_314 1671-0008 2.74 µM 0.182270334446921 0.396369509106729 no 1327 0.427685289186455 2015 3913060 SGTC_3055 9094636 49.47 µM 0.179457229990752 0.397529080842224 no 1328 0.428789348813254 2037 25236176 SGTC_2289 7946404 165.07 µM 0.179110367144769 0.397672121905705 no 1329 0.428925520918714 1970 1246120 YPR165W RHO1 SGTC_2378 9074213 121.43 µM 0.177668401805068 0.398266914187847 no 1330 0.429491701048431 2082 657714 SGTC_832 4083-0019 164 µM 0.176603619427016 0.398706275166749 no 1331 0.429909875442127 2063 1990758 SGTC_3153 9100258 49.47 µM 0.176527738484763 0.398737590815343 no 1332 0.429939679343686 1934 25236848 SGTC_3257 9139206 32.98 µM 0.17587520216657 0.399006915862813 no 1333 0.430195993731459 2078 4910041 SGTC_1480 1070-0044 41.2 µM 0.175344912155073 0.399225820917699 no 1334 0.430404311793826 2100 3124987 SGTC_1562 morin hydrate 59.1 µM 0.173766458280894 0.39987759797226 no 1335 0.431024502864331 1990 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2603 homopterocarpin 100 µM 0.172286966496391 0.400488764884974 no 1336 0.431605965186504 1976 101795 A weak amylase inhibitor. SGTC_1604 st002052 72.4 µM 0.170372366631385 0.401280033261426 no 1337 0.432358651322788 2015 6254834 YHR062C RPP1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.168127157299064 0.402208452166992 no 1338 0.433241622502871 1919 23665772 A membrane-active detergent. SGTC_911 3456-4043 236 µM 0.167607970878833 0.402423220266397 no 1339 0.433445850030985 2054 914281 SGTC_2953 9074162 66.49 µM 0.167207651047836 0.402588837797541 no 1340 0.43360333225332 2143 16451992 SGTC_947 3447-0010 211 µM 0.16692660564879 0.4027051203896 no 1341 0.433713899286223 2104 748350 SGTC_3151 9099821 49.47 µM 0.166672931739883 0.402810085413228 no 1342 0.433813702461756 1988 17174189 SGTC_2470 5664817 21.68 µM 0.16633440881271 0.402950170118779 no 1343 0.433946894441982 2146 2859561 SGTC_978 1416-0512 87.4 µM 0.16566490252468 0.403227256237787 no 1344 0.434210334027048 2015 6814003 SGTC_216 k038-0035 28.382 µM 0.164323174960604 0.403782698264596 no 1345 0.43473836934258 2082 4444231 YPR107C YTH1 SGTC_562 3772-2733 112 µM 0.163386246501763 0.404170678630651 no 1346 0.435107165538219 2101 2876874 YIL048W NEO1 SGTC_1965 Pectolinarigenin 58.4 µM 0.163059682076358 0.404305930539841 no 1347 0.435235721954474 1999 5320438 An anti-inflammatory. SGTC_1027 k015-0025 8.67 µM 0.160577862910213 0.405334188529322 no 1348 0.436212945725069 2077 3598955 SGTC_2938 9059746 27.26 µM 0.160417987624728 0.405400449945188 no 1349 0.436275910517465 2065 6471769 SGTC_232 clozapine 119 µM 0.160326133068713 0.405438520926608 no 1350 0.436312086964793 2072 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_996 3970-0799 1.8 µM 0.159965881533483 0.405587843104832 no 1351 0.43645397532975 2112 6615648 YGL040C HEM2 SGTC_1335 1486-0900 202 µM 0.159597623782723 0.405740498015012 no 1352 0.436599025467425 2131 X1335 SGTC_1859 st055998 20 µM 0.158175053238111 0.406330334594685 no 1353 0.437159430450873 2159 676301 SGTC_2070 5230947 200 µM 0.157596826569126 0.406570144009514 no 1354 0.437387252177163 2129 2835538 SGTC_638 3970-0837 4.09 µM 0.156819347458111 0.406892645119688 no 1355 0.437693612222108 1989 4118451 YLR208W SEC13 SGTC_2812 7970281 58.44 µM 0.156479367546895 0.407033689857081 no 1356 0.43782759060734 2104 2233435 SGTC_1847 st056231 15 µM 0.155055881303022 0.40762437089845 no 1357 0.438388631531291 2126 5393180 SGTC_502 l-744,832 89.3 µM 0.153188979121262 0.408399367306041 no 1358 0.439124624240102 2138 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1719 st032227 49.2 µM 0.152904016999029 0.40851769360257 no 1359 0.439236984028074 2007 3125804 SGTC_778 3456-2434 196 µM 0.152227512661612 0.40879863538374 no 1360 0.439503747435489 2153 5539063 SGTC_2279 7948423 32.93 µM 0.152200203495726 0.408809977442773 no 1361 0.439514516733726 2157 1247112 SGTC_487 nimodipine 119 µM 0.152023978470495 0.408883169161114 no 1362 0.439584011688188 2149 4497 L-type voltage-gated calcium channels inhibitor SGTC_2131 toluylene red 5.2905 µM 0.150508539136676 0.409512709007955 no 1363 0.440181707111116 2007 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2451 5856223 45.7 µM 0.149128083306212 0.410086377551031 no 1364 0.44072628319351 2025 2179896 SGTC_2770 toltrazuril 17.5 µM 0.148199033133159 0.410472566334866 no 1365 0.441092847420374 2140 68591 Kills coccidiodes. SGTC_1476 4112-3294 3.34 µM 0.148116690223351 0.410506798936769 no 1366 0.441125338918051 2113 704369 SGTC_397 arbidol 50 µM 0.147235571073986 0.410873151201506 no 1367 0.441473042442519 2130 131410 A RNA synthesis inhibitor. SGTC_2705 st078069 42.8 µM 0.146971098260145 0.410983129058718 no 1368 0.441577416403789 2047 1530061 SGTC_1470 k295-0292 231 µM 0.146337011166018 0.411246835078676 no 1369 0.441827674823284 2121 5045612 SGTC_525 k781-2675 26.7 µM 0.146090970992786 0.411349169802157 no 1370 0.441924787024845 2170 3651118 YDL195W SEC31 SGTC_1709 st033179 39.1045 µM 0.146011618636815 0.411382175867351 no 1371 0.441956108191301 2143 573381 SGTC_2175 5807670 165.306 µM 0.145897918452904 0.411429469767828 no 1372 0.442000987420543 2134 241186 SGTC_535 2293-4129 48.2 µM 0.144431722634558 0.412039452974509 no 1373 0.442579784190003 2143 396118 YIL048W NEO1 SGTC_2704 st078022 71.1 µM 0.143966942549755 0.412232860436327 no 1374 0.442763286836925 2159 54697681 SGTC_4 0960-0234 25.671 µM 0.142187331905877 0.412973600847909 no 1375 0.44346601889884 2043 6821112 SGTC_3323 9138564 53.9225 µM 0.140787695542589 0.413556399668862 no 1376 0.444018831888376 2146 43912313 YNL103W MET4 SGTC_1087 pterostilbene 9.05 µM 0.140648957953178 0.413614179431281 no 1377 0.444073634888827 2138 5281727 Similar to reservatol, lowers cholesterol. SGTC_66 0109-0187 42.4 µM 0.140091223408164 0.413846476868315 no 1378 0.444293957458068 2179 759417 SGTC_111 0083-0039 52.457 µM 0.139851723965521 0.413946238073342 no 1379 0.444388572507415 2179 759313 SGTC_137 0438-0332 85.389 µM 0.13982680786194 0.413956616957319 no 1380 0.444398415878882 2144 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_597 k018-0003 82.8 µM 0.139738469126305 0.413993415229159 no 1381 0.444433315311337 2126 6786234 SGTC_672 1441-0018 53.7 µM 0.139161703128748 0.414233690689064 no 1382 0.444661185227739 2049 251141 SGTC_1932 st074806 40.9 µM 0.138995088399001 0.414303106847905 no 1383 0.444727015131875 2088 17251235 SGTC_3058 9093861 49.47 µM 0.138527266283425 0.414498028374614 no 1384 0.444911860985559 2118 17217477 SGTC_1446 4239-0190 62 µM 0.138151487137411 0.414654614773975 no 1385 0.445060347503024 1989 1340085 SGTC_2896 9052656 71.43 µM 0.137913052586808 0.414753976996743 no 1386 0.445154567257031 2132 6469436 SGTC_51 1013-0126 23.419 µM 0.137798661121889 0.41480164899691 no 1387 0.445199771267787 2204 1627850 SGTC_504 lovastatin 124 µM 0.136920087714729 0.415167831302309 no 1388 0.445546980335859 1989 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1591 genipin 88.4 µM 0.136629238349349 0.415289071224572 no 1389 0.445661932180396 2155 442424 A DNA cross-linking agent. SGTC_2067 5224629 34.075 µM 0.136577447782461 0.415310660855574 no 1390 0.445682401747596 2023 2835000 SGTC_885 0865-0106 16.8 µM 0.136398704809381 0.415385174358101 no 1391 0.445753048761159 2125 2793380 SGTC_2552 juarezic acid 87.02 µM 0.13541224752542 0.415796458551148 no 1392 0.446142970598398 2199 1549512 SGTC_2849 9019321 12.99 µM 0.13443825109807 0.416202637945327 no 1393 0.446528018078703 2087 16489627 SGTC_1887 st057648 70.8 µM 0.133793424112393 0.41647159522341 no 1394 0.446782963620912 2168 688672 SGTC_1994 st072947 40.9 µM 0.133647375085171 0.416532517696565 no 1395 0.446840710150941 2086 5286565 YDL195W SEC31 SGTC_3054 9094397 49.47 µM 0.133227648840805 0.416707612256729 no 1396 0.447006672570482 2095 2598354 SGTC_3162 9099653 49.47 µM 0.132934586950538 0.416829876843923 no 1397 0.44712255660488 2164 25237511 SGTC_3345 9148410 3.559 µM 0.131718442454646 0.417337334705472 no 1398 0.447603498824484 2164 4903596 SGTC_961 1252-1571 372 µM 0.131392329518006 0.417473434563729 no 1399 0.447732478108886 2168 6813498 SGTC_2576 guaiol 23.12 µM 0.130638997014994 0.417787867860042 no 1400 0.44803044595834 2184 227829 SGTC_2486 5283202 22.39 µM 0.130483538090843 0.41785276137753 no 1401 0.448091938745554 2028 1377751 SGTC_1690 st023502 41.2 µM 0.130005776302962 0.418052208391818 no 1402 0.448280928325059 2176 24207482 SGTC_3056 9094900 49.47 µM 0.129551763815569 0.418241760526232 no 1403 0.44846053420541 2057 25236784 SGTC_269 exalamide 29 µM 0.12781919228775 0.41896529061404 no 1404 0.449146030698927 2075 3316 A derivative of salicylamide. SGTC_2330 7979373 200 µM 0.126964430691948 0.419322344258032 no 1405 0.449484275431643 2016 1863007 SGTC_958 1222-0007 33 µM 0.125309192773013 0.420013964007136 no 1406 0.450139387384852 2148 7312461 SGTC_2671 danthron 100 µM 0.125154832253705 0.420078474181285 no 1407 0.450200487322046 2096 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2447 5741742 33.78 µM 0.123637879480599 0.420712551347956 no 1408 0.450800999543124 2138 1776504 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.123574231774153 0.420739160216956 no 1409 0.450826198069827 2208 16725076 SGTC_2333 9017922 200 µM 0.122633677534812 0.421132415039176 no 1410 0.451198592450761 2168 3163164 SGTC_1969 st069479 40.1 µM 0.122399623339197 0.421230287605204 no 1411 0.451291268400168 2185 3895485 SGTC_1831 st055328 12 µM 0.122266017270588 0.421286158766201 no 1412 0.451344172164218 2181 1103068 SGTC_3185 9108267 49.47 µM 0.120701534169349 0.421940509331697 no 1413 0.451963721895359 2059 4910486 SGTC_1638 st008370 60.6 µM 0.120676855189343 0.421950833133692 no 1414 0.451973495940285 2187 24207134 SGTC_2588 indole-3-carbinol 100 µM 0.120282357384708 0.422115868187788 no 1415 0.45212973970281 2190 3712 Induces cell cycle arrest. SGTC_3160 9100216 49.47 µM 0.118644263374784 0.422801297921341 no 1416 0.452778597947164 2215 17191039 SGTC_1716 st033144 30.6155 µM 0.11832016212502 0.42293693978293 no 1417 0.452906991273118 2199 674617 SGTC_1212 0520-0165 585 µM 0.117907444522195 0.423109682311983 no 1418 0.453070497261068 2212 5403258 SGTC_3011 9081274 71.4286 µM 0.117604923038698 0.423236311759725 no 1419 0.453190351999733 2090 6625322 SGTC_1630 st005209 31.3 µM 0.117577774700544 0.42324767589952 no 1420 0.453201107996511 2224 3367314 SGTC_1796 st049173 110.4 µM 0.11753245859157 0.423266645106997 no 1421 0.453219062023593 2194 94134 SGTC_738 1315-0003 72.4 µM 0.116058264460063 0.423883835772192 no 1422 0.453803182681323 2192 6251474 SGTC_3140 9094243 49.47 µM 0.11531115481462 0.424196694403792 no 1423 0.454099248539447 2242 19291112 SGTC_2581 avocatin a 64 µM 0.115023867005578 0.424317011389098 no 1424 0.454213102231132 2111 6710728 A skin care supplement. SGTC_205 1486-1330 71.903 µM 0.114286713993631 0.424625765496116 no 1425 0.454505257093382 2128 4118834 SGTC_3075 9116269 49.47 µM 0.112328919203527 0.425446005442525 no 1426 0.455281306347689 2121 17015205 YNL244C SUI1 SGTC_1812 st052057 4.327 µM 0.111049707419559 0.425982120053709 no 1427 0.455788464819066 2180 3645418 SGTC_336 4111-0029 111 µM 0.110755847670065 0.426105295338042 no 1428 0.455904979159721 2105 3131175 SGTC_3107 9121808 49.47 µM 0.109045690441374 0.426822273537941 no 1429 0.456583125325711 2210 662681 SGTC_1791 st048313 56.1 µM 0.108896081320411 0.426885008243691 no 1430 0.456642457407714 2227 1204976 SGTC_3231 9132313 49.47 µM 0.108510751138959 0.427046594976546 no 1431 0.45679527634822 2123 4905967 SGTC_731 3966-0296 387 µM 0.108444814073075 0.427074246659476 no 1432 0.456821427114461 2195 660956 SGTC_1386 3228-0095 33.8 µM 0.106505050394365 0.42788787498873 no 1433 0.457590824283474 2189 870181 SGTC_3286 9117135 37.221 µM 0.106294840720781 0.427976065317086 no 1434 0.457674212454828 2099 3438150 SGTC_2003 4023581 200 µM 0.105912874843072 0.428136322600674 no 1435 0.457825739439496 2125 16641307 SGTC_2363 9053361 176 µM 0.104747440159648 0.4286253645497 no 1436 0.458288108592739 2220 6469797 YMR079W SEC14 SGTC_2962 9082311 13.18 µM 0.104512886609091 0.428723801637126 no 1437 0.458381171124468 2127 16459453 SGTC_1000 4048-0884 8.67 µM 0.104491527174278 0.428732765953525 no 1438 0.458389645904218 2141 13040088 SGTC_1733 st037357 54.9 µM 0.103784008862518 0.429029724243907 no 1439 0.458670378505757 2216 1272339 YGL099W LSG1 SGTC_2978 9011784 42.97 µM 0.103732625428517 0.429051292371549 no 1440 0.458690767482464 2232 2994934 SGTC_2099 5377090 177.372 µM 0.103141216894096 0.429299550546888 no 1441 0.458925446545666 2120 2243829 SGTC_1503 4585-0012 61.3 µM 0.103119719136469 0.429308575283014 no 1442 0.458933977422525 2172 2922052 SGTC_2808 7946468 45.46 µM 0.100519571316074 0.43040038574496 no 1443 0.459965922932599 2169 2970879 SGTC_1946 st076057 65.1 µM 0.0999015909122457 0.430659956313535 no 1444 0.460211226653199 2220 953009 SGTC_2140 5586273 200 µM 0.0966065266487665 0.43204448663407 no 1445 0.461519436612939 2239 854421 SGTC_836 0330-0104 1.35 µM 0.0948445900932484 0.432785166332079 no 1446 0.462219134355976 2244 46494820 SGTC_1881 5652484 16 µM 0.0946845913371086 0.432852438057641 no 1447 0.462282678658678 2241 2255129 SGTC_2041 5107442 45.335 µM 0.0932940018731746 0.433437195310424 no 1448 0.4628349985568 2230 793005 SGTC_1388 3346-4487 254 µM 0.0931564998654394 0.433495024265723 no 1449 0.46288961606591 2182 3345614 SGTC_2 0422-0095 29 µM 0.09280147647044 0.433644342354128 no 1450 0.463030639010423 2169 6790840 SGTC_671 0560-0003 407 µM 0.0927028750024456 0.433685814493263 no 1451 0.46306980646389 2199 3238678 SGTC_998 3996-0085 177 µM 0.0918437093981361 0.434047213546423 no 1452 0.463411107860112 2203 715391 SGTC_853 0419-0306 21 µM 0.0916525759220183 0.434127619357947 no 1453 0.463487038828456 2098 762713 SGTC_1762 st045503 25.4615 µM 0.0916397754973417 0.43413300432333 no 1454 0.463492124058684 2150 4645554 SGTC_2779 methotrexate 400 µM 0.0916074503159808 0.434146603143951 no 1455 0.463504965923964 2239 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2702 st077768 96.8 µM 0.0913125558787419 0.434270665334535 no 1456 0.463622120760554 2147 6484119 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0880889678408989 0.435627249516402 no 1457 0.464902982340227 2217 65057 A dermal irritant. YDR527W RBA50 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0878140565734491 0.435742975859333 no 1458 0.465012232698264 2169 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2814 7977482 42.97 µM 0.0873770518354191 0.435926948211874 no 1459 0.465185904792527 2215 6456762 SGTC_426 0988-0037 14.6 µM 0.0867982818711518 0.436170622904883 no 1460 0.465415926669664 2287 5383008 SGTC_2013 4024628 200 µM 0.0862663580311328 0.436394595733669 no 1461 0.465627340576372 2191 5230760 SGTC_583 1488-1091 88.9 µM 0.0845298798732065 0.437125902010335 no 1462 0.466317573572817 2269 4303273 SGTC_1656 st012921 11 µM 0.083854752834112 0.437410285443374 no 1463 0.466585957401937 2244 6732821 SGTC_1472 k841-0093 193 µM 0.0836988104850114 0.437475977565733 no 1464 0.466647951461882 2235 X1472 SGTC_1328 1441-0025 69.2 µM 0.0830961017279834 0.43772989025877 no 1465 0.466887562749159 2243 4562601 SGTC_1097 itavastatin 7.23 µM 0.0825226467790371 0.437971502543799 no 1466 0.467115555112861 2268 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1647 st011722 22.4 µM 0.0820183993342398 0.438183974921831 no 1467 0.467316041098307 2237 2854783 SGTC_1049 3226-0134 66 µM 0.0819191716963211 0.438225788106045 no 1468 0.467355494434408 2244 5702385 SGTC_2540 epiandrosterone 100 µM 0.080945740296618 0.438636015424131 no 1469 0.467742551895302 2287 441302 A steroid. SGTC_5 0352-0601 109.883 µM 0.080525291535214 0.438813223022528 no 1470 0.467909740905181 2183 762456 SGTC_757 1066-0008 322 µM 0.0792355811165414 0.439356876889131 no 1471 0.468422621954896 2239 6842497 SGTC_591 4299-0174 154 µM 0.0760706579901508 0.440691475181446 no 1472 0.469681442006346 2220 5509088 SGTC_179 1273-0063 6.77 µM 0.0755748007030152 0.440900631850467 no 1473 0.469878692620094 2241 3108139 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0747065367321936 0.441266912387223 no 1474 0.470224103324923 2258 91467 include heat shock SGTC_1737 st035557 69.7 µM 0.073819794146234 0.441641040054961 no 1475 0.470576888272649 2290 5716916 SGTC_563 tetrahydrosecaminediol 614 µM 0.0737247033140976 0.441681163150865 no 1476 0.470614720936656 2272 334274 A psychoactive constituent of the cannabis plant. SGTC_2924 9010168 62.78 µM 0.0731048140973009 0.44194273691993 no 1477 0.470861355407883 2197 2993929 SGTC_2125 5246583 200 µM 0.0728722664700531 0.442040871247354 no 1478 0.470953881700948 2276 835267 SGTC_771 0250-0039 27.3 µM 0.0723554972518947 0.442258958870441 no 1479 0.471159499984233 2156 3005115 SGTC_2960 9079389 5.97 µM 0.0707508031354252 0.442936285244703 no 1480 0.471798043527389 2290 16457355 SGTC_46 0329-0187a 2.197 µM 0.0701329314944838 0.44319712766859 no 1481 0.472043927841572 2217 46494817 SGTC_2745 rifampicin 24.3 µM 0.0680919548524055 0.444058926448978 no 1482 0.472856217295951 2283 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_391 gliotoxin 8.33 µM 0.0673483382720861 0.444372983211959 no 1483 0.473152197918463 2240 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2630 antimycin a 100 µM 0.0654038514617183 0.445194376445868 no 1484 0.473926228812438 2279 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1249 0481-0015 10.2 µM 0.0652867064145397 0.445243868595876 no 1485 0.47397286325365 2264 4227577 SGTC_1768 st044301 37.178 µM 0.0650637107867345 0.445338083499143 no 1486 0.474061636890698 2286 3931349 SGTC_2406 ethylparaben 405.7 µM 0.0633497115086205 0.446062345105465 no 1487 0.474744015583653 2016 8434 A possible steroid mimic. SGTC_1978 st071761 42 µM 0.0631775806556249 0.446135090109445 no 1488 0.474812548576856 2136 5147680 SGTC_2952 9073731 13.78 µM 0.0605769918865499 0.447234356011184 no 1489 0.475848048839857 2259 16457353 SGTC_2420 aureobasidin a 50 nM 0.0595260498968432 0.447678703505967 no 1490 0.476266558721785 2280 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1950 st077106 7.18 µM 0.0579795751672625 0.448332685852363 no 1491 0.476882448904358 2146 13831864 SGTC_2658 polymyxin b sulfate 77.05 µM 0.0567378011542921 0.448857916310568 no 1492 0.477377030767671 2271 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_689 0833-0039 98 µM 0.0566095794241215 0.448912155098896 no 1493 0.477428101753541 2286 5374726 SGTC_1699 st031318 29.054 µM 0.0561021946945831 0.449126792137093 no 1494 0.477630197790377 2279 5340658 SGTC_58 0957-0393 9 µM 0.0559574190305306 0.449188038770148 no 1495 0.477687864335388 2291 6997992 SGTC_473 2-arachidonoylglycerol 10 µM 0.0557124740788494 0.449291664284235 no 1496 0.477785431030049 2232 5282280 An endocannabinoid. SGTC_1063 disulfiram 1.84 µM 0.0555006836294367 0.449381266364413 no 1497 0.477869792666918 2311 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3253 9135987 49.47 µM 0.0553992260174248 0.449424190900623 no 1498 0.477910206220493 2290 4182430 SGTC_1954 st077032 68.9 µM 0.0553214317873295 0.449457104369182 no 1499 0.47794119410633 2101 698907 SGTC_874 0599-0792 117 µM 0.054938677077884 0.449619046697485 no 1500 0.47809365927045 2302 765305 SGTC_2060 5238662 140 µM 0.0542618181999983 0.449905444109129 no 1501 0.478363284687979 2234 790130 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0533177676948249 0.450304941115004 no 1502 0.478739361881717 2306 2346 DNA damaging agent; causes G2/M arrest. SGTC_2643 anethole 100 µM 0.05268724119057 0.450571791197027 no 1503 0.47899055248057 2296 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1784 st039334 36.3 µM 0.0523853512822203 0.450699564318038 no 1504 0.47911082303688 2312 3496984 SGTC_110 0850-0284 111.64 µM 0.0523163949219795 0.450728750407609 no 1505 0.479138294973686 2323 3906265 SGTC_598 3937-0236 20.2 µM 0.0518281983020685 0.450935389433412 no 1506 0.47933279337221 2285 1379313 SGTC_659 k018-0002 107 µM 0.0510323250825262 0.451272287246475 no 1507 0.479649881203493 2310 6797879 YHR007C ERG11 SGTC_1683 st010134 710 nM 0.0502604661270968 0.451599053212349 no 1508 0.479957413695415 2319 3818134 SGTC_639 0833-0042 114 µM 0.0500109194358877 0.451704705661386 no 1509 0.480056843380041 2271 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_278 4092-0821 23.9 µM 0.0497719403621689 0.451805887225792 no 1510 0.480152063653675 2283 877900 SGTC_2617 dihydrotanshinone i 20.83 µM 0.0478208161199814 0.452632092008468 no 1511 0.480929523334438 2306 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_206 4546-0025 72.014 µM 0.0476094755892415 0.452721596665291 no 1512 0.481013740083352 2258 6620745 YIL048W NEO1 SGTC_1745 st081495 74 µM 0.0467012934923 0.453106247415101 no 1513 0.481375649707333 2299 13842402 YBL026W LSM2 SGTC_812 4251-0442 148 µM 0.0456759740158489 0.453540563306356 no 1514 0.481784256887769 2316 5723007 SGTC_2308 7584454 197.62 µM 0.0449357340333294 0.453854156721915 no 1515 0.48207926698042 2314 893577 SGTC_1221 2958-7315 257 µM 0.0436426940902143 0.454402005840676 no 1516 0.482594609569046 2293 4562705 SGTC_1292 0kpi-0043 232 µM 0.0431566370330042 0.454607966232342 no 1517 0.482788335747384 2284 3333905 SGTC_3252 9135871 49.47 µM 0.0418102833652503 0.45517852973978 no 1518 0.483324968621341 2320 17682838 SGTC_2403 6032726 181.2 µM 0.0417622659469651 0.455198880481129 no 1519 0.483344108082755 2291 2881040 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0416740380200979 0.455236273545936 no 1520 0.483379275317162 2324 803109 SGTC_2017 5132927 60.65 µM 0.041575487832324 0.455278041895926 no 1521 0.48341855710882 2309 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_927 2425-1185 123 µM 0.0414324296625946 0.455338674863953 no 1522 0.483475579926934 2329 730375 SGTC_2760 etidronate 98.04 µM 0.0411171527961602 0.455472303704175 no 1523 0.483601250106477 2322 3305 A chelator and antioxidant. SGTC_2798 7813637 45.45 µM 0.0405791277410908 0.455700355100323 no 1524 0.483815712049176 2304 956368 SGTC_42 0133-0086 60.653 µM 0.0401857484357149 0.455867105089837 no 1525 0.483972519776756 2337 162923 Model of phenazepam hydroxylation. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0395759270539046 0.456125618307312 no 1526 0.484215609913654 2327 6708784 An antioxidant flavonoid SGTC_515 4092-1064 102 µM 0.0386313920220449 0.456526058717876 no 1527 0.484592136876151 2338 717353 SGTC_1961 st076550 68.7 µM 0.0369165527341037 0.457253186093731 no 1528 0.485275770785097 2315 1579337 SGTC_1222 0366-0074 1.18 µM 0.0364801846412473 0.45743823814367 no 1529 0.485449739278528 2335 286520 SGTC_285 1486-1325 46 µM 0.035121853576144 0.458014328950417 no 1530 0.485991287763486 2336 22310230 SGTC_1825 st052143 62.6 µM 0.0348780226592185 0.458117751073338 no 1531 0.486088502663121 2340 674173 SGTC_2095 5432005 200 µM 0.0346329280029873 0.458221712075419 no 1532 0.486186222246275 2345 783734 SGTC_2549 cedrol 20.94 µM 0.0345181243941176 0.458270408931613 no 1533 0.486231994891748 2347 6708665 A sedative which affects the nervous system. SGTC_160 3453-0671 289.699 µM 0.0342360247451474 0.458390071296168 no 1534 0.486344469888463 2335 5322268 SGTC_3197 9113331 49.47 µM 0.0339124430218587 0.458527334366381 no 1535 0.486473485399791 2314 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1191 1487-1166 10.6 µM 0.0338078337613498 0.458571710577346 no 1536 0.486515194539904 2314 3955771 SGTC_2149 5554786 194.827 µM 0.0336855220390892 0.45862359699022 no 1537 0.486563962080194 2316 745063 YPR165W RHO1 SGTC_1367 1812-0510 76.9 µM 0.0336780944130082 0.45862674792003 no 1538 0.486566923593939 2321 1142582 YDR527W RBA50 SGTC_3225 9130819 49.47 µM 0.0326057751817828 0.459081671804893 no 1539 0.486994482175824 2341 4547121 SGTC_3059 1327-0034 3 µM 0.0303577412968004 0.460035557589582 no 1540 0.487890873434396 2327 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_673 1082-0474 110 µM 0.0301758285374503 0.460112756950632 no 1541 0.487963412891824 2328 3098046 SGTC_2612 dictamnine 15.46 µM 0.0295875164862193 0.460362432590249 no 1542 0.488198010678499 2303 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3280 9140961 49.47 µM 0.0273791524703878 0.461299785925968 no 1543 0.489078662966835 2342 4901226 SGTC_62 0180-0423 3.232 µM 0.0265806228085724 0.461638779834031 no 1544 0.489397114278897 2331 30102 YGL099W LSG1 SGTC_540 1187-0821 17.3 µM 0.0265240416324012 0.461662800883781 no 1545 0.489419678946599 2352 847520 SGTC_1216 1165-0504 9.65 µM 0.0255879404146901 0.462060234803585 no 1546 0.48979300253851 2357 6304004 SGTC_3020 9089140 49.47 µM 0.0250472649046313 0.462289802893335 no 1547 0.490008631738639 2342 17217859 SGTC_432 NS 1619 61.3 µM 0.0230344273996267 0.463144553360416 no 1548 0.490811405567463 2269 4552 A K+/calcium channel activator. SGTC_1157 4092-0394 27.6 µM 0.0229009669980118 0.463201233314366 no 1549 0.490864634522996 2361 3659885 SGTC_3209 9113616 49.47 µM 0.0221016980007549 0.46354069438728 no 1550 0.491183415999598 2372 16649353 SGTC_3137 9097352 49.47 µM 0.0206694147232735 0.46414907200619 no 1551 0.491754683660388 2348 44120435 SGTC_1167 k781-0610 148 µM 0.0198477687087715 0.464498112858285 no 1552 0.492082405728683 2345 4525169 SGTC_2620 irigenin 100 µM 0.0196825281297064 0.464568311496034 no 1553 0.49214831430682 2360 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2801 7907800 81.82 µM 0.0195614437304974 0.464619752102473 no 1554 0.492196610694643 2361 6620925 SGTC_418 lividomycin a 100 µM 0.0176505523916925 0.465431638884546 no 1555 0.492958813984607 2380 72394 An antibiotic. SGTC_768 0384-0033 77.3 µM 0.0172171695365778 0.465615791846433 no 1556 0.493131682454985 2361 3965305 YMR134W ERG29 SGTC_2971 9092186 9.93 µM 0.0169544832449377 0.46572741604309 no 1557 0.493236463827609 2359 25236400 SGTC_928 2764-0428 58.7 µM 0.0168650459217612 0.465765421570677 no 1558 0.493272139056404 2299 662578 SGTC_2320 7373003 200 µM 0.0164838311654194 0.465927418600909 no 1559 0.493424200598872 2372 5415828 SGTC_814 3342-0569 96 µM 0.0149717038918033 0.466570051723082 no 1560 0.494027377437876 2375 4346283 SGTC_3331 9141060 1.957 µM 0.0131137292162732 0.467359784368799 no 1561 0.494768528904911 2375 4906567 YPR165W RHO1 SGTC_380 3970-0968 6 µM 0.0128521026016558 0.467470999225604 no 1562 0.494872894026803 2371 2891601 SGTC_1800 st050079 29.0735 µM 0.0116983806089964 0.4679614650758 no 1563 0.495333127808303 2365 3645560 SGTC_3078 9116413 49.47 µM 0.0116392700971313 0.467986595225105 no 1564 0.495356707885295 2386 17177322 SGTC_664 1222-0054 14.9 µM 0.0114844793233261 0.468052403333496 no 1565 0.495418456342209 2381 6813991 SGTC_612 0302-0167 22.4 µM 0.0105384995734709 0.468454598262391 no 1566 0.495795824767559 2369 235821 SGTC_2310 7668677 200 µM 0.0104934073136804 0.468473770598635 no 1567 0.495813812981863 2379 2197143 SGTC_2821 7996764 71.43 µM 0.00995466598299721 0.468702838390594 no 1568 0.496028728441324 2379 2987135 SGTC_150 3970-0969 77.2 µM 0.00913264550250963 0.469052373777016 no 1569 0.496356652222901 2361 6615640 SGTC_2784 7567673 72.73 µM 0.00793872023423297 0.469560091046099 no 1570 0.496832942112717 2388 3471247 SGTC_1688 st021091 57.6 µM 0.00570679449116433 0.470509350613286 no 1571 0.497723330749492 2396 3656366 SGTC_2928 9011484 9.79 µM 0.00512871748364221 0.470755239889703 no 1572 0.497953946721355 2394 2994751 SGTC_3080 9117754 49.47 µM 0.00469012431351136 0.470941806141545 no 1573 0.498128917970786 2403 9550191 SGTC_176 1486-1328 72.834 µM 0.00455933559951926 0.470997441532301 no 1574 0.498181094560576 2386 22310231 SGTC_109 0132-0036 33.701 µM 0.00448135921223417 0.471030611688043 no 1575 0.498212202320507 2389 67274 A color developer. SGTC_1067 clotrimazole 1.36 µM 0.00443548070161164 0.47105012791237 no 1576 0.498230505016248 2392 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1442 4112-3290 3 µM 0.00433818492328274 0.471091516718649 no 1577 0.498269320042427 2394 704353 SGTC_2029 5175081 200 µM 0.00433558677433223 0.471092621953656 no 1578 0.498270356544146 2392 1380876 SGTC_834 0312-0008 75.7 µM 0.00127171732514794 0.472396123937701 no 1579 0.49949265832703 2403 6385573 YIL048W NEO1 SGTC_644 1498-1197 63.3 µM 0.000773077303514218 0.472608295219404 no 1580 0.49969158680833 2404 6741615 SGTC_2021 4019055 173 µM 0 0.472937254882756 no 1581 0.5 2405 44827708 YER133W GLC7 SGTC_381 3461-2219 42.7 µM -0.00162402496487286 0.473628369434835 no 1582 0.499352108061883 2411 2883159 SGTC_2005 4024620 188 µM -0.00214074942931933 0.473848281690304 no 1583 0.499145965193212 2415 236743 SGTC_119 0121-0043 24.815 µM -0.0027172856707422 0.474093658584756 no 1584 0.498915961192038 2412 1092378 SGTC_1502 4534-4282 27.7 µM -0.00342593217304213 0.474395275764964 no 1585 0.498633253479973 2416 3278949 SGTC_3263 9137018 49.47 µM -0.00369800683892279 0.474511081266098 no 1586 0.49852471208123 2413 43844957 SGTC_922 1866-0035 480 µM -0.00524806567175341 0.475170887054096 no 1587 0.497906334323909 2420 3156169 SGTC_352 k048-0007 5.11 µM -0.00535406765204254 0.475216010894906 no 1588 0.497864046246365 2414 6811911 SGTC_405 ebelactone b 50 µM -0.00680878950117276 0.47583530135714 no 1589 0.497283706977361 2416 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2109 5483026 200 µM -0.00782084806739628 0.476266179906876 no 1590 0.496879964843856 2424 759335 SGTC_1940 st075990 51.1 µM -0.0081648620529715 0.476412648376207 no 1591 0.496742727504461 2509 1084979 SGTC_2390 9097792 176.6 µM -0.0092592569128658 0.476878622451119 no 1592 0.496306143713847 2427 4497149 SGTC_3233 9132340 49.47 µM -0.0101554880732344 0.477260245486024 no 1593 0.495948616068791 2427 17682950 SGTC_828 2074-0507 139 µM -0.0106376880066575 0.477465579068877 no 1594 0.495756256525865 2442 X828 SGTC_2627 acetyl isogambogic acid 100 µM -0.0114783988372815 0.477823590422175 no 1595 0.495420881945297 2445 6857789 A caspase activator and apoptosis inducer. SGTC_2412 st077135 33.4 µM -0.0126799103085126 0.478335277425284 no 1596 0.494941583215414 2506 13258915 SGTC_1806 st050005 60.3 µM -0.0127231456362488 0.478353690700296 no 1597 0.49492433620645 2429 5194765 SGTC_2772 vinpocetine 57.06 µM -0.013092831303979 0.478511136141704 no 1598 0.494776865250008 2432 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1619 st003326 88.7 µM -0.0138214435461556 0.478821454628729 no 1599 0.494486217345581 2436 2849032 SGTC_2124 5246320 200 µM -0.0145787436197635 0.479144004967342 no 1600 0.494184128792991 2456 579342 SGTC_3232 9132874 49.47 µM -0.0152947926839869 0.47944899818327 no 1601 0.493898498417383 2436 3784940 SGTC_1109 tnp00067 928.257 nM -0.0165521633930364 0.479984590402698 no 1602 0.493396943702864 2444 676295 SGTC_2521 angolensin 13.4 µM -0.0179848017458232 0.480594883980184 no 1603 0.492825488950671 2471 821428 A flavenoid. SGTC_679 0422-0091 41.4 µM -0.0182166770261547 0.480693665487124 no 1604 0.492732999250528 2445 627384 YHR062C RPP1 SGTC_1264 0783-0040 158 µM -0.0187403394609636 0.480916755993503 no 1605 0.492524123830862 2435 2855798 SGTC_895 0964-0006 13.7 µM -0.0199298193985879 0.481423519960752 no 1606 0.492049678712846 2424 6738897 SGTC_869 0564-0080 44.1 µM -0.0218574662961255 0.482244834683683 no 1607 0.491280826820022 2482 6843321 SGTC_3214 9129694 49.47 µM -0.0235303576184534 0.482957666609448 no 1608 0.49061361165339 2446 17158655 SGTC_402 epigallocatechin gallate 10 µM -0.0235930849114581 0.482984396267872 no 1609 0.490588594029369 2458 65064 An antioxidant. SGTC_1366 1683-0113 21.9 µM -0.0236476140348615 0.483007632544635 no 1610 0.490566846124185 2451 708623 SGTC_729 4092-0585 94.1 µM -0.0252270372801232 0.48368069056809 no 1611 0.489936935592432 2452 2169061 SGTC_180 1486-1293 102.781 µM -0.0253087714496716 0.483715522183797 no 1612 0.489904338784109 2461 4140536 SGTC_3083 9117465 49.47 µM -0.0256155865824694 0.483846274809175 no 1613 0.489781976927255 2512 16420915 SGTC_2399 5884133 200 µM -0.0272499905183064 0.48454282285945 no 1614 0.489130171911872 2468 722445 SGTC_2048 5246248 200 µM -0.0275091272946136 0.484653265806072 no 1615 0.48902683003756 2475 677046 SGTC_1149 3909-7961 23.3 µM -0.0281804249781742 0.4849393753609 no 1616 0.488759124814149 2464 735261 SGTC_70 0141-0289 43.283 µM -0.0286948896683953 0.485158647369977 no 1617 0.488553966072455 2549 352408 SGTC_3317 9138495 8.753 µM -0.0288645202479806 0.485230947270234 no 1618 0.488486321282215 2443 17020139 SGTC_1201 1889-3372 45.9 µM -0.0292446216533928 0.48539295574888 no 1619 0.488334746752363 2502 5392199 SGTC_1006 4099-6547 255 µM -0.0300406076264945 0.485732232141472 no 1620 0.488017333785044 2497 3146833 SGTC_581 0958-0271 211 µM -0.0301464560139483 0.485777349120697 no 1621 0.487975125504669 2450 4591145 SGTC_2964 9083345 53.42 µM -0.030896312408956 0.486096974241898 no 1622 0.487676115396079 2481 17741579 SGTC_985 1493-0307 8.71 µM -0.031390985228405 0.486307832663542 no 1623 0.487478865177787 2468 3278274 SGTC_952 1185-0122 232 µM -0.0317568587432787 0.486463791771708 no 1624 0.487332975501989 2449 678600 SGTC_1520 flindersine 88 µM -0.0338169396608005 0.487341970317326 no 1625 0.486511563887627 2517 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_20 0481-0013 4.944 µM -0.0346695485996405 0.487705441659371 no 1626 0.486171621510181 2457 182045 SGTC_495 decylubiquinone 155 µM -0.0346933800089398 0.487715601253308 no 1627 0.486162119869435 2518 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1587 estradiol valerate 56.1 µM -0.0349513549497702 0.487825579338875 no 1628 0.48605926513813 2476 13791 A steroid. SGTC_1030 k029-0042 36.7 µM -0.0350737872033366 0.487877774131586 no 1629 0.486010451664634 2513 6080581 SGTC_2221 6807166 181.081 µM -0.0366668222237105 0.488556928582677 no 1630 0.485375331437276 2475 674925 SGTC_154 3389-1638 511.116 µM -0.0368439306367337 0.488632436834593 no 1631 0.485304723113739 2536 5238686 SGTC_2556 citropten 84.59 µM -0.0370225935726589 0.488708608253317 no 1632 0.485233495510893 2464 2775 A potential DNA crosslinker. SGTC_567 1080-0542 68.4 µM -0.0376909019907712 0.488993539475848 no 1633 0.484967065001821 2479 5950415 SGTC_1304 1165-0502 251 µM -0.0386983296341738 0.489423063698739 no 1634 0.484565452586112 2496 767425 SGTC_1276 0871-0068 94.2 µM -0.0388885200443232 0.489504154177658 no 1635 0.484489634662087 2512 3414906 SGTC_831 k061-1017 217 µM -0.0402166781574148 0.490070445832616 no 1636 0.483960190569923 2507 1240153 SGTC_1413 3910-0535 34.4 µM -0.0406221076356086 0.490243314329261 no 1637 0.483798579678454 2524 2876951 SGTC_1206 3978-0017 132 µM -0.0421273836909759 0.490885155190011 no 1638 0.4831985752574 2660 3873677 SGTC_991 3996-0057 64.7 µM -0.0423573953345395 0.49098323292274 no 1639 0.483106895721875 2522 715343 SGTC_2105 5350118 200 µM -0.0424217667865377 0.491010681222669 no 1640 0.483081238290004 2498 2133313 SGTC_1469 k284-2957 126 µM -0.0429244669877018 0.491225036485305 no 1641 0.482880872443172 2522 23884841 SGTC_1034 k072-0165 12.7 µM -0.0430668700631925 0.491285758723885 no 1642 0.482824114322113 2494 5835461 SGTC_2090 5301565 104.445 µM -0.0431759824524068 0.491332285584189 no 1643 0.482780625228621 2486 2056344 SGTC_2777 climbazole 1.536 µM -0.0446824720621442 0.491974682999355 no 1644 0.482180202505607 2481 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1305 1181-0477 144 µM -0.0447192379619955 0.491990360984163 no 1645 0.482165549680387 2512 6252086 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0457946717797578 0.492448960737947 no 1646 0.48173695283048 2488 140250 A respiratory chain inhibitor. SGTC_2044 5102272 200 µM -0.0458763023980798 0.492483771088278 no 1647 0.481704421116227 2534 592666 SGTC_3300 9124615 50.48 µM -0.0470728987536153 0.492994050982624 no 1648 0.481227563523638 2556 24824903 SGTC_3159 9100096 49.47 µM -0.0478017891939253 0.493304886731309 no 1649 0.480937105308857 2474 25236875 SGTC_274 sirtinol 40.1 µM -0.0496888605553387 0.494109647823998 no 1650 0.480185166742104 2514 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1837 st055472 66.5 µM -0.0498711627478175 0.494187393800917 no 1651 0.480112528745871 2603 676091 SGTC_1094 duloxetine 25.4 µM -0.0508820213952785 0.494618496178607 no 1652 0.479709765899382 2478 60834 A selective serotonin reuptake inhibitor. SGTC_1245 0418-0076 17.2 µM -0.0539307321531808 0.495918720363232 no 1653 0.478495175785134 2573 6790114 SGTC_382 3229-0966 23.2 µM -0.0545766731413629 0.49619420943105 no 1654 0.478237861595138 2544 5722370 SGTC_1995 st072814 61.1 µM -0.0546134500653504 0.496209894573762 no 1655 0.478223211574572 2507 5769371 SGTC_104 0074-0074 590.992 µM -0.0546721267264114 0.496234919838211 no 1656 0.478199837894634 2487 3943124 SGTC_943 3253-1379 105 µM -0.0550066439080941 0.496377589806409 no 1657 0.478066585367719 2550 668464 SGTC_411 enrofloxacin 100 µM -0.0557803169940619 0.496707559398749 no 1658 0.477758407645144 2520 71188 A bacterial gyrase inhibitor. SGTC_282 k297-0036 65.7 µM -0.0560613510858568 0.496827420289679 no 1659 0.477646466428876 2553 5061378 SGTC_2409 alverine citrate 63.97 µM -0.056228444512577 0.496898685683909 no 1660 0.477579910778977 2783 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_87 0100-0052 35.5 µM -0.0565680175034161 0.497043513964033 no 1661 0.477444656033912 2534 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1453 4237-0541 195 µM -0.056662236526593 0.497083698558144 no 1662 0.477407128273533 2496 739892 SGTC_2393 9031399 185.94 µM -0.0570812488003845 0.49726240844938 no 1663 0.477240236677766 2553 1526623 YDL150W RPC53 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0574320547617951 0.497412028584139 no 1664 0.47710051456326 2525 115019 SGTC_1494 4358-1428 177 µM -0.05818811870719 0.497734494067555 no 1665 0.47679939229279 2500 1564571 SGTC_2030 5175110 200 µM -0.0584899433756097 0.497863224394756 no 1666 0.476679186402813 2583 2831986 SGTC_3106 9121286 49.47 µM -0.058974038706361 0.498069694890283 no 1667 0.476486393111522 2685 15943471 SGTC_2684 capsaicin 100 µM -0.0590418275573785 0.498098607415076 no 1668 0.476459396314216 2568 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3091 9116372 49.47 µM -0.0593424961878613 0.49822684527604 no 1669 0.476339656835749 2648 17169793 SGTC_1767 st044992 70.3 µM -0.0597734621378823 0.49841065642573 no 1670 0.476168030959899 2543 9600693 SGTC_1233 0325-0408 14.2 µM -0.0601817634472682 0.498584801198664 no 1671 0.476005435023062 2570 12874 SGTC_1809 st050081 57.6 µM -0.0603645638187347 0.498662767555715 no 1672 0.47593264057209 2596 5036894 SGTC_421 streptovitacin 30 mM -0.0606991232003829 0.498805460919986 no 1673 0.475799414989982 2705 91467 include heat shock SGTC_212 3807-4682 38.772 µM -0.0611985478963467 0.499018471486238 no 1674 0.475600543088947 2583 3125501 YBL034C STU1 SGTC_2315 7733312 200 µM -0.0615091435585741 0.499150944371202 no 1675 0.475476866344707 2546 726316 SGTC_1373 2887-0003 58.5 µM -0.0620009761390539 0.499360717225281 no 1676 0.475281027326113 2572 776948 SGTC_3334 9142812 21.919 µM -0.0627976861956687 0.499700524552093 no 1677 0.474963804191375 2602 45283678 SGTC_3061 glucosamine 200 µM -0.0629714913687545 0.499774654783743 no 1678 0.474894602921949 2492 91431 and experimental redox chemotherapeutic SGTC_217 ketoconazole 989 nM -0.0640281765293854 0.499774654783743 no 1679 0.474473895603543 2506 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2265 7929201 200 µM -0.064220200803417 0.499692753862342 no 1680 0.474397446339876 2502 1265108 SGTC_2877 9040724 71.43 µM -0.065642992466355 0.499085914819948 no 1681 0.473831029934008 2529 6463895 SGTC_3303 9125618 40.5795 µM -0.0656967552845316 0.499062984315427 no 1682 0.47380962787106 2585 22695467 SGTC_1154 4088-0362 150 µM -0.0665135647866133 0.498714605421374 no 1683 0.473484479243582 2515 6618304 SGTC_842 0271-0008 11.1 µM -0.068448896991755 0.497889167788453 no 1684 0.472714149450271 2638 1221709 SGTC_464 bw-b 70c 158 µM -0.0688098346977791 0.497735225310203 no 1685 0.472570494844061 2641 5353454 SGTC_83 0170-0301 39.027 µM -0.0697453130990009 0.497336238798025 no 1686 0.47219818746649 2522 3089716 SGTC_1849 st056239 19.2 µM -0.0704652410669222 0.497029187485141 no 1687 0.471911682682855 2549 5393181 SGTC_787 4152-0075 138 µM -0.0704663883008388 0.497028698187989 no 1688 0.471911226137621 2559 9566539 SGTC_2056 5235370 200 µM -0.070782073578002 0.496894058070705 no 1689 0.471785599623604 2579 5511916 SGTC_2411 st077133 39.94 µM -0.0713294858202521 0.496660586995942 no 1690 0.471567764349634 2813 1403142 YNL221C POP1 SGTC_1650 st011916 45.8 µM -0.0714390068669346 0.496613876453608 no 1691 0.471524182954206 2544 242528 SGTC_1072 oxiconazole 14.9 nM -0.0718920568220291 0.496420651909543 no 1692 0.471343905715752 2523 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3101 9120531 49.47 µM -0.0722732278224025 0.496258084188063 no 1693 0.471192235034242 2547 24824904 SGTC_1125 tnp00248 1.32998 µM -0.0743636471494721 0.495366541490044 no 1694 0.470360517027759 2599 24207736 SGTC_617 3770-0098 35 µM -0.0757375012941771 0.49478061891948 no 1695 0.469813969972084 2558 5962639 SGTC_3215 9129942 49.47 µM -0.0765627703035933 0.494428662770844 no 1696 0.469485688488441 2574 17682944 SGTC_2281 7943571 200 µM -0.0766026000309516 0.494411676517196 no 1697 0.469469845253922 2575 1244024 SGTC_781 4335-2806 94.4 µM -0.0773380018713483 0.494098050258017 no 1698 0.469177330150134 2702 845254 SGTC_3339 9145883 14.936 µM -0.0777584630413065 0.493918738131844 no 1699 0.469010094026477 2565 2030670 SGTC_2950 9072895 21.46 µM -0.0788125173977945 0.493469225937481 no 1700 0.468590873787774 2593 17332245 SGTC_1936 st074407 74.3 µM -0.079103376415975 0.493345187588348 no 1701 0.468475198969849 2550 809813 SGTC_1912 st060209 90.8 µM -0.0791261487086693 0.493335476252063 no 1702 0.468466142526667 2604 688787 SGTC_1640 st009078 66.4 µM -0.0795491421383447 0.493155089718093 no 1703 0.468297922824735 2580 690618 SGTC_60 0986-0278 202 µM -0.0799421045639126 0.492987511229211 no 1704 0.468141651184546 2539 3110598 SGTC_2706 st078239 82.5 µM -0.0800436542546421 0.492944205650862 no 1705 0.468101268129052 2559 15434492 SGTC_986 1493-0483 84 µM -0.0804487552911613 0.492771452292378 no 1706 0.467940175708305 2535 40079 SGTC_772 k072-0172 35.3 µM -0.0807651386437987 0.492636533098124 no 1707 0.46781436639901 2572 5861980 SGTC_2423 st077119 87.2 µM -0.0814736576609354 0.492334393810192 no 1708 0.467532636680083 2508 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1498 4478-3555 97.6 µM -0.0818845961550492 0.492159156108528 no 1709 0.46736924189386 2543 3437919 SGTC_1748 st037455 53.6035 µM -0.0828771955862402 0.491735885343226 no 1710 0.466974593466944 2642 580690 SGTC_2910 7948405 25.97 µM -0.0836346001247021 0.491412914161856 no 1711 0.466673478187864 2590 2971328 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.083752231920243 0.491362754307304 no 1712 0.466626713960343 2638 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3242 9133940 49.47 µM -0.0839393230703969 0.491282976287252 no 1713 0.466552337288645 2704 17248444 SGTC_790 1575-0012 79.1 µM -0.0847471950415428 0.490938493559875 no 1714 0.466231187340725 2539 378741 YLR208W SEC13 SGTC_3087 9117406 49.47 µM -0.0847816450334363 0.49092380397083 no 1715 0.466217493067599 2651 42546093 SGTC_328 k915-0120 63.5 µM -0.0851425924232674 0.490769895569022 no 1716 0.466074014683017 2669 6624543 SGTC_1041 0206-0046 107 µM -0.085293623438072 0.490705496168879 no 1717 0.466013980410085 2658 50494 SGTC_1403 3909-7815 62.9 µM -0.0853390969558921 0.490686106375876 no 1718 0.465995905005406 2560 6615483 SGTC_1497 4476-2978 41.3 µM -0.0863718755693052 0.490245738202555 no 1719 0.465585401703553 2639 1528379 SGTC_2575 plumbagin 510 nM -0.0864161771112248 0.490226848657274 no 1720 0.4655677937803 2551 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3031 9088762 49.47 µM -0.0877962285107832 0.489638425624097 no 1721 0.465019317701752 2553 205253 SGTC_2795 7780010 54.55 µM -0.0883313389031199 0.489410272524786 no 1722 0.464806665727354 2656 953673 SGTC_3000 9075062 71.4286 µM -0.0883811209333314 0.48938904731409 no 1723 0.464786882941964 2592 17057871 SGTC_2191 5911152 200 µM -0.0884407523344472 0.489363622736628 no 1724 0.464763186248563 2572 2875902 SGTC_122 0236-0016 402.397 µM -0.0887125730967974 0.489247729177928 no 1725 0.464655170024539 2573 6808838 SGTC_948 3448-0295 75.3 µM -0.0888068108761615 0.489207550149479 no 1726 0.46461772239239 2565 678569 SGTC_202 3594-0513 34.79 µM -0.0889577519266112 0.489143195457765 no 1727 0.464557743014452 2534 708429 SGTC_1681 tripelennamine 100 µM -0.089076822956081 0.489092428954679 no 1728 0.464510428380723 2549 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1170 0310-0127 64.8 µM -0.0896281253265158 0.488857380867668 no 1729 0.464291366785451 2630 774975 SGTC_649 1123-0311 367 µM -0.0898970958225178 0.488742706539449 no 1730 0.464184494503599 2629 693629 YIL048W NEO1 SGTC_3218 9131285 49.47 µM -0.0908636217218582 0.488330640436091 no 1731 0.463800478119387 2594 17156417 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0915826811808775 0.488024086578826 no 1732 0.463514806015018 2566 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2639 lactacystin 53 µM -0.0915850620091612 0.488023071581101 no 1733 0.463513860176941 2632 3870 A proteasome inhibitor. SGTC_1208 2323-2347 50.3 µM -0.0919648006153849 0.487861181935583 no 1734 0.463363003039472 2592 5412760 SGTC_254 nsc-64875 3.808 µM -0.0932381791246717 0.487318331694938 no 1735 0.462857171962967 2726 56993 SGTC_1523 st012844 44.7 µM -0.0935783658405598 0.487173311633735 no 1736 0.462722047873082 2692 4274103 SGTC_1150 3909-7983 10.9 µM -0.0936322660792029 0.487150334360497 no 1737 0.462700638787443 2595 23965914 SGTC_2142 5622915 118.518 µM -0.0938009247673862 0.487078436684559 no 1738 0.462633648533737 2615 5322196 SGTC_1937 st074714 47.2 µM -0.095200439021133 0.486481852814953 no 1739 0.462077810641917 2568 17250970 SGTC_1736 st036774 51 µM -0.095205146410977 0.486479846202698 no 1740 0.462075941156412 2778 1272247 SGTC_17 0960-0276 49.807 µM -0.0959577871578667 0.486159023558178 no 1741 0.461777049380858 2581 6821114 SGTC_2754 granisetron 64.02 µM -0.0960035730775135 0.486139507017372 no 1742 0.461758867383765 2651 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_734 2023-0417 80 µM -0.0964038260350964 0.485968898055458 no 1743 0.461599926771375 2669 3935732 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0964066421566643 0.485967697684689 no 1744 0.461598808510051 2579 688669 SGTC_2889 9059656 51.95 µM -0.098133181227232 0.485231785401339 no 1745 0.460913269933548 2660 3949838 SGTC_2253 7938677 135.83 µM -0.0984265429672506 0.4851067491368 no 1746 0.460796799383393 2780 2301972 SGTC_338 4055-0136 114 µM -0.0992830434005321 0.48474170104441 no 1747 0.460456770649633 2573 2900563 SGTC_410 α-linolenic acid 100 µM -0.0996602175429397 0.484580950112218 no 1748 0.46030704252377 2692 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2408 sulbentine 18.36 µM -0.100421292856217 0.484256588857472 no 1749 0.460004932978068 2717 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_142 0335-0849 62.6745 µM -0.101173494666957 0.483936019619508 no 1750 0.45970636846327 2589 3889043 YPR107C YTH1 SGTC_2189 6047310 154.431 µM -0.102325789591167 0.4834449611024 no 1751 0.459249042805444 2564 711535 SGTC_2845 9003024 42.97 µM -0.102662921160474 0.483301294848131 no 1752 0.45911525136362 2760 2990173 SGTC_531 3788-1495 174 µM -0.103123587202834 0.483104988753368 no 1753 0.458932442470442 2570 2896655 SGTC_1427 4048-4900 550 nM -0.103280916619487 0.483037946059909 no 1754 0.458870010473477 2684 24132586 SGTC_712 r015-0009 80.6 µM -0.104364074552399 0.482576393713445 no 1755 0.458440215654943 2669 6813872 YLR060W FRS1 SGTC_1720 st037298 9.481 µM -0.106162435888526 0.481810132683194 no 1756 0.457726737144814 2667 597396 SGTC_2674 ligustilide 100 µM -0.108560228320481 0.480788565984568 no 1757 0.456775653726416 2681 5319022 A signalling regulator. SGTC_173 1273-0061 2.693 µM -0.110091275427067 0.480136337086729 no 1758 0.456168493649784 2695 2847414 YPL266W DIM1 SGTC_690 glyoxal 20.3 µM -0.110195562024222 0.480091912718267 no 1759 0.456127140916068 2600 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2165 5727197 32.143 µM -0.110478544279289 0.479971368197472 no 1760 0.456014932441226 3013 1361712 SGTC_513 4245-1575 41.7 µM -0.110828679051121 0.479822220645791 no 1761 0.45587610142352 2749 719745 SGTC_2582 agaric acid 100 µM -0.111749320305263 0.479430066933902 no 1762 0.455511086129619 2645 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1326 1431-2094 10.8 µM -0.112332082135027 0.479181845640309 no 1763 0.45528005245648 2594 616278 SGTC_290 2043-6722 48.1 µM -0.112341915301497 0.479177657375105 no 1764 0.455276154265199 2656 773758 YLR208W SEC13 SGTC_1128 3448-9350 235 µM -0.11331453568574 0.478763398175848 no 1765 0.45489059682647 2710 619386 SGTC_2446 5162541 200 µM -0.113981869686907 0.478479180023276 no 1766 0.454626082830836 2601 1549321 SGTC_2894 9048625 32.47 µM -0.114446403918541 0.478281340927205 no 1767 0.454441965306194 2672 4092861 SGTC_1889 st059080 5.18 µM -0.115014177334736 0.478039540875955 no 1768 0.454216942365031 2594 176925 Isolated from Daphnopsis sellowiana. SGTC_1514 1189-1591 158 µM -0.115689064632514 0.477752134307803 no 1769 0.453949486607429 2803 767698 YMR146C TIF34 SGTC_900 1112-0045 141 µM -0.115907937109183 0.477658928056033 no 1770 0.45386275259732 2651 56211 YIL048W NEO1 SGTC_2069 5228469 200 µM -0.117379402846487 0.47703234033058 no 1771 0.453279702689342 2721 2835210 SGTC_3305 9127027 53.8275 µM -0.117945835046472 0.476791154070858 no 1772 0.45305528778307 2676 41905295 SGTC_3050 9093513 49.47 µM -0.118066048020623 0.476739968598285 no 1773 0.45300766250275 2634 25236664 SGTC_1434 4073-0095 163 µM -0.118179392027814 0.476691708214086 no 1774 0.452962759149106 2631 24133745 SGTC_2676 harmalol 100 µM -0.119005118131467 0.476340135285516 no 1775 0.452635650458712 2621 5459187 A monoamine oxidase inhibitor SGTC_1813 st051246 8.6015 µM -0.120758881892448 0.475593489238024 no 1776 0.451941009593359 2639 5291959 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.121158396099256 0.475423412254102 no 1777 0.45178278819777 2639 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2113 5491891 107.031 µM -0.121283794239418 0.47537002999936 no 1778 0.45173312779026 2627 789979 SGTC_169 k015-0017 16.025 µM -0.121604472258489 0.475233518698417 no 1779 0.451606135714655 2682 1840002 SGTC_2482 5981709 142.65 µM -0.122215349282597 0.474973478943772 no 1780 0.451364235305909 2690 877755 SGTC_256 clotrimazole 625 nM -0.122855036773475 0.474701186501606 no 1781 0.451110945635823 2614 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.123320430265627 0.474503092296619 no 1782 0.450926681650866 2818 165506 SGTC_833 3852-0053 558 µM -0.123490448932231 0.474430725616068 no 1783 0.45085936852526 2752 3123681 SGTC_3296 9122258 64.045 µM -0.123789867168414 0.474303283404566 no 1784 0.450740827465314 2720 4730474 SGTC_2947 9072639 7.68 µM -0.124268540428481 0.474099549849273 no 1785 0.450551327645995 2685 16488146 SGTC_892 0929-0076 29 µM -0.124779661534189 0.473882013277612 no 1786 0.45034899463894 2643 5751038 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.125161829008138 0.473719365321589 no 1787 0.450197717797803 2841 804 An inhibitor of viral and cellular DNA polymerases. SGTC_218 alverine citrate 93.75 µM -0.126224087951759 0.47326729801804 no 1788 0.449777272215531 2725 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2261 9010538 184.68 µM -0.126245106122964 0.473258353625415 no 1789 0.449768953721446 2750 6457250 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.126513197623856 0.473144267070122 no 1790 0.449662851396059 2705 551469 SGTC_1333 1482-0047 286 µM -0.127244196826001 0.472833200987242 no 1791 0.449373562823387 2617 3811116 SGTC_1268 0828-0275 2.46 µM -0.12785374349712 0.472573829922092 no 1792 0.449132358931448 2734 745337 SGTC_1019 4262-0212 3.4 µM -0.12820710802715 0.472423473440058 no 1793 0.448992537551039 2622 4677213 SGTC_931 2812-0076 566 µM -0.130307185831391 0.471529972878529 no 1794 0.448161697537296 2627 3450959 SGTC_2699 st077704 54.6 µM -0.131824763335987 0.470884392216124 no 1795 0.447561449585325 2694 645852 SGTC_735 3076-0345 636 µM -0.132759004614393 0.470487001950184 no 1796 0.44719198843535 2744 2888990 SGTC_7 0192-1582 4.227 µM -0.133895729596672 0.470003522585432 no 1797 0.446742513583748 2656 252616 SGTC_1751 st044839 27.194 µM -0.134666594368683 0.4696756784154 no 1798 0.44643774318795 2614 5291326 SGTC_1838 st055369 84.5 µM -0.135206460869311 0.469446088652964 no 1799 0.446224319484147 2631 676036 SGTC_456 gingerol 170 µM -0.136173668863063 0.469034788244588 no 1800 0.445841995224498 2802 442793 A herb. SGTC_1980 st071811 45.7 µM -0.136335773798741 0.468965857144944 no 1801 0.445777922249521 2798 4974850 SGTC_3148 9097893 49.47 µM -0.136808926951824 0.468764665840357 no 1802 0.445590913653999 2679 17174100 SGTC_1428 4049-0204 61.7 µM -0.13731063333343 0.46855134201973 no 1803 0.445392632931652 2748 X1428 SGTC_263 alizarin 107.927 µM -0.137400466931563 0.468513146035417 no 1804 0.445357130995225 2631 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2075 5212009 200 µM -0.138053552516131 0.46823547195141 no 1805 0.445099046955022 2739 780898 SGTC_2141 5621638 7.665 µM -0.138296634811307 0.46813212396345 no 1806 0.445002992493761 2771 2856238 SGTC_1289 0976-0073 69.1 µM -0.139721408748627 0.467526415650408 no 1807 0.444440055297817 2763 3391136 SGTC_3200 9114385 49.47 µM -0.140836139457244 0.467052567096424 no 1808 0.443999696217114 2784 17018030 YLR208W SEC13 SGTC_2318 6029776 164 µM -0.141463951811115 0.466785717792612 no 1809 0.443751717951107 2788 818325 SGTC_1836 st055642 81 µM -0.14169591002603 0.466687128587364 no 1810 0.443660102835693 2677 8571 SGTC_2782 7736369 71.43 µM -0.142310321854959 0.466425995007262 no 1811 0.443417446922841 2701 2950836 YOL077C BRX1 SGTC_2093 5331342 194.4 µM -0.14253886964665 0.466328862696218 no 1812 0.443327189627893 2769 33839 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.143002005007263 0.46613203733778 no 1813 0.443144298851188 2767 6708739 YPR165W RHO1 SGTC_1892 st058411 7.36 µM -0.144074292617078 0.465676363574871 no 1814 0.442720902213193 2794 3934738 SGTC_1482 3346-2049 8.48 µM -0.144151083806688 0.465643732510081 no 1815 0.442690583438482 2757 3826804 SGTC_431 k089-0097 107 µM -0.144705586477058 0.46540811322704 no 1816 0.442471664108688 2654 5499420 SGTC_2651 TUB2.036 5 µM -0.145391855901572 0.465116520413177 no 1817 0.442200747195748 2743 15992207 YFL037W TUB2 SGTC_1380 2291-0730 164 µM -0.146012889971179 0.464852661950263 no 1818 0.441955606380084 2739 2999191 SGTC_1820 st053765 18.6 µM -0.146436920508985 0.464672513159488 no 1819 0.4417882415445 2735 3690829 SGTC_741 4582-0002 126 µM -0.146845445751037 0.46449895862078 no 1820 0.441627006477097 2666 2912688 SGTC_670 4204-0025 119 µM -0.147193676227478 0.464351024550739 no 1821 0.441489575935785 2782 719039 SGTC_3032 9089427 49.47 µM -0.14906779341767 0.463554953687044 no 1822 0.440750069517015 2768 17173707 SGTC_2923 7992654 58.14 µM -0.149405248627713 0.463411627867438 no 1823 0.440616935205046 2713 2985126 SGTC_163 TUB2.036 7.546 µM -0.150101680539268 0.463115850537315 no 1824 0.440342197064615 2687 15992207 YJR013W GPI14 SGTC_3213 9129884 49.47 µM -0.152385132784149 0.462146203413837 no 1825 0.439441591227003 2774 17190742 SGTC_1653 st012112 65 µM -0.152426373807295 0.462128692840914 no 1826 0.439425328412573 2823 720429 SGTC_2591 skatole 100 µM -0.152882962297275 0.461934834327024 no 1827 0.439245286033919 2801 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2508 celastrol 40.54 µM -0.153285679262854 0.461763856109163 no 1828 0.439086496752034 2652 122724 Celastrol is a natural product and antioxidant. SGTC_138 0850-0259 40.9225 µM -0.1533521086629 0.461735653405213 no 1829 0.439060304913517 2716 6813004 SGTC_843 0310-0051 143 µM -0.153794884755276 0.461547677056366 no 1830 0.438885733613055 2694 2065037 SGTC_3254 9136651 49.47 µM -0.154363384822003 0.461306338398983 no 1831 0.438661611131668 2675 16454030 SGTC_2925 9010536 32.5 µM -0.154434752485381 0.461276042527762 no 1832 0.438633476906766 2775 2994177 SGTC_1203 3992-3522 103 µM -0.154489017594398 0.461253006912699 no 1833 0.438612084977996 3019 5322312 SGTC_524 r073-0010 27.8 µM -0.155070449548205 0.461006196405454 no 1834 0.438382889096232 2663 2772106 SGTC_1048 3161-0300 24.5 µM -0.155433398506839 0.460852136773141 no 1835 0.438239827955559 2672 2165101 SGTC_1144 3486-0183 12.5 µM -0.156185301937581 0.460532997762407 no 1836 0.437943480955227 2709 6744069 SGTC_891 0929-0073 133 µM -0.156533847438558 0.460385069202034 no 1837 0.437806120835587 2830 5603632 SGTC_323 4013-0906 34.3 µM -0.161880843387871 0.458116413766138 no 1838 0.435699844297525 2809 2910086 SGTC_1951 sophoraflavanone G 9.2 µM -0.162381786220443 0.457903939471882 no 1839 0.435502606486567 2687 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1179 1021-1431 9.29 µM -0.162531730329882 0.457840343196401 no 1840 0.435443571634197 2775 2840958 SGTC_3202 9113761 49.47 µM -0.164241864449926 0.457115095287385 no 1841 0.434770372750166 2893 4798415 SGTC_1624 st003710 6.25 µM -0.164479445974338 0.457014350980382 no 1842 0.434676863059233 2872 24207033 SGTC_571 k831-0106 44.2 µM -0.165952220261798 0.456389896189866 no 1843 0.434097275691953 2728 4783639 SGTC_1441 4106-0040 13 µM -0.167412933116648 0.455770661798989 no 1844 0.4335225748147 2686 2904180 SGTC_3248 9135562 49.47 µM -0.167664376501179 0.455664079166417 no 1845 0.433423661415002 2743 17650701 SGTC_2917 7979103 53.79 µM -0.168404966664083 0.455350173987616 no 1846 0.43313235053737 2856 2980565 SGTC_95 0471-0001 561.058 µM -0.170192600207484 0.454592586156089 no 1847 0.432429335501455 2718 4015405 SGTC_2219 9098279 200 µM -0.170376884323669 0.454514497051752 no 1848 0.432356874993536 2722 902349 SGTC_1420 4'-methoxyflavone 42 µM -0.170528933217948 0.454450068720515 no 1849 0.432297091086549 2711 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1262 0737-0114 49.6 µM -0.172945088793246 0.453426422684642 no 1850 0.431347294938105 2765 765919 SGTC_625 k213-0058 121 µM -0.173688109145092 0.453111691161869 no 1851 0.431055291505255 2763 3655420 SGTC_377 3970-0964 33.1 µM -0.174427927162723 0.452798345357276 no 1852 0.430764584012625 2710 16481235 SGTC_2546 rhodinyl acetate 100 µM -0.174915490773177 0.452591856558577 no 1853 0.430573019023635 2719 6708682 SGTC_2297 7971671 152.32 µM -0.175854767910661 0.452194098071661 no 1854 0.430204020723953 2870 909016 SGTC_2424 5537928 59.2 µM -0.176342318913196 0.451987652286202 no 1855 0.430012508619692 2738 5382802 SGTC_594 1487-1584 10.8 µM -0.176871376979395 0.451763645677271 no 1856 0.429804710992907 2741 5013332 SGTC_3038 9091290 49.47 µM -0.179082851029922 0.450827460319835 no 1857 0.428936323612164 2850 25236843 SGTC_602 3130-1533 38.1 µM -0.179096394616646 0.450821727738012 no 1858 0.428931006458944 2846 720941 SGTC_1337 1486-1011 40.3 µM -0.179173941563258 0.450788904708931 no 1859 0.428900562113475 2718 X1337 SGTC_1219 1469-0211 33.1 µM -0.179702008639272 0.45056540053582 no 1860 0.428693258225279 2805 6822282 SGTC_588 3970-1144 52.9 µM -0.180463677425591 0.450243052163677 no 1861 0.428394283713222 2866 1888707 SGTC_929 2805-0021 398 µM -0.181114721084913 0.449967547827853 no 1862 0.428138764964518 2832 3098024 SGTC_1007 4101-0031 70 µM -0.182759813509855 0.449271496268869 no 1863 0.427493240816003 2905 1146276 SGTC_1162 k048-0130 20.1 µM -0.184054031439957 0.448724012055296 no 1864 0.426985533959714 2730 6797406 SGTC_2037 5169046 200 µM -0.185152278591942 0.448259504558879 no 1865 0.426554799005529 2849 5718022 SGTC_2242 6630449 61.2675 µM -0.18575026120384 0.448006615493573 no 1866 0.426320305699423 2924 691249 YDR170C SEC7 SGTC_1779 st039427 55 µM -0.186203463524721 0.447814968620452 no 1867 0.426142603979822 2741 1124498 SGTC_520 3584-0023 682 µM -0.186364377799587 0.447746925300263 no 1868 0.426079512711274 2805 1340790 SGTC_102 gallobenzophenone 83.616 µM -0.186835463491786 0.447547733457381 no 1869 0.425894820317124 2896 70837 SGTC_3290 9121031 71.43 µM -0.186958053584861 0.447495900158028 no 1870 0.425846760689585 2773 17014854 SGTC_2823 7987624 58.44 µM -0.187152404737838 0.447413726827993 no 1871 0.425770570460621 2920 2239440 SGTC_2448 5185112 27.17 µM -0.187973618561722 0.447066535558042 no 1872 0.425448665928729 2875 5718189 SGTC_413 propylparaben 100 µM -0.188794180650488 0.446719660341454 no 1873 0.425127066496304 2726 7175 A pharmaceutical preservative. SGTC_1675 st018485 24.5 µM -0.188798522882781 0.446717824863049 no 1874 0.425125364795873 2821 3323024 SGTC_2071 5230951 39.92 µM -0.188959313695521 0.446649858767908 no 1875 0.425062352614472 2755 1799272 SGTC_1696 st025591 34.7925 µM -0.190041928873518 0.446192279449044 no 1876 0.424638137347637 2756 2787147 SGTC_289 k017-0060 526 µM -0.190624024228815 0.445946279966257 no 1877 0.424410083355797 2751 5512909 SGTC_1855 st056195 39.6 µM -0.190945127220079 0.445810587438449 no 1878 0.424284292078724 2926 4028379 SGTC_406 estrone 100 µM -0.19120450701688 0.445700982690259 no 1879 0.42418268633607 2924 5870 A steroid. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.19161634411785 0.445526963394147 no 1880 0.424021369497969 2891 5282362 SGTC_1609 st001574 46.4 µM -0.192013639327114 0.445359098631929 no 1881 0.423865760790706 2747 3960012 SGTC_2832 7992762 51.95 µM -0.192920995681336 0.444975760142522 no 1882 0.423510420865949 2733 2985177 SGTC_2481 5478948 45.16 µM -0.193857811484101 0.444580029657857 no 1883 0.423143609259654 2883 77792 SGTC_1953 st076800 12.1 µM -0.193882566700297 0.444569573286872 no 1884 0.423133917220296 2768 297591 SGTC_1464 k208-0027 110 µM -0.194612085058675 0.444261448928338 no 1885 0.422848320722721 2949 X1464 SGTC_2022 5136654 200 µM -0.19465807260271 0.444242026441717 no 1886 0.422830318582757 2903 1713771 SGTC_722 3534-0461 190 µM -0.195623224587597 0.443834432866263 no 1887 0.42245254044758 2789 658262 SGTC_63 0099-0242 26.702 µM -0.196344057209016 0.443530056589735 no 1888 0.422170439884302 2869 3898502 YLR359W ADE13 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.196526032561741 0.443453221569467 no 1889 0.422099229450108 2815 75037 A free radical scavenger. SGTC_1915 st067105 30.6 µM -0.196934496340157 0.443280764625772 no 1890 0.421939399042237 2714 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_12 0849-0099 9.267 µM -0.197643897067177 0.442981275047315 no 1891 0.42166184365685 2738 6071388 SGTC_2644 guaiazulene 100 µM -0.197769275212373 0.442928347207063 no 1892 0.421612793084663 2859 3515 A coloring agent. SGTC_22 0964-0034 14.468 µM -0.198091374483469 0.442792379067759 no 1893 0.421486786640568 2786 138402 SGTC_2066 5222451 176 µM -0.198814371393819 0.442487204100025 no 1894 0.421203976830281 2754 2281147 SGTC_1695 st026914 34.495 µM -0.19936276131042 0.442255753001977 no 1895 0.420989493957778 2733 3289191 SGTC_32 0928-0142 34.1 µM -0.199515106668458 0.44219145826797 no 1896 0.420929913742676 2769 2244242 SGTC_2178 5812956 200 µM -0.19969598086256 0.442115125407487 no 1897 0.420859178635979 2688 5403383 SGTC_2553 4-methylesculetin 85.09 µM -0.200036341821115 0.441971491478697 no 1898 0.420726079408913 2795 5319502 SGTC_2102 5377816 72.7585 µM -0.201816043650327 0.441220573586661 no 1899 0.420030269300574 2943 1379702 SGTC_2236 dapsone 200 µM -0.202039686512532 0.44112622579722 no 1900 0.419942849269246 2792 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_810 3825-7150 143 µM -0.203157069685544 0.440654887635232 no 1901 0.419506133249544 2963 22330411 YGL099W LSG1 SGTC_159 3970-0959 50 µM -0.203342343224779 0.44057674306248 no 1902 0.419433730840904 2863 6615653 SGTC_2975 9084847 53.72 µM -0.203363405651273 0.44056785951011 no 1903 0.419425500100381 2869 27211724 SGTC_1350 1495-0454 146 µM -0.203643690589699 0.440449645878924 no 1904 0.419315974168771 2926 1069057 SGTC_1711 st032263 62.8 µM -0.203871765642089 0.440353456327397 no 1905 0.419226854718231 2823 3958979 SGTC_1927 st060202 13.8 µM -0.20507315525324 0.439846834296529 no 1906 0.418757484849314 2732 688887 SGTC_2239 6685329 187.64 µM -0.206071073041798 0.439426090500899 no 1907 0.418367697092877 2902 805680 SGTC_1627 st003713 25.6 µM -0.207267034069833 0.438921937547498 no 1908 0.417900659053266 2850 16195070 YER133W GLC7 SGTC_2019 4016004 108 µM -0.207997435543909 0.438614088180775 no 1909 0.41761548485358 2848 45595336 SGTC_1496 4469-0713 57.4 µM -0.208386718702894 0.438450028404764 no 1910 0.417463512824575 2895 746691 SGTC_824 1304-0008 100 µM -0.209855180740293 0.437831254127895 no 1911 0.416890351916546 2791 768245 SGTC_1156 4092-0367 4.88 µM -0.209991228776668 0.437773934455823 no 1912 0.416837259419372 2811 1357585 SGTC_743 1275-0778 158 µM -0.210264915077972 0.437658629074196 no 1913 0.416730458436943 2898 2849257 YMR203W TOM40 SGTC_2592 piperlongumine 83.33 µM -0.210540706738853 0.437542442049232 no 1914 0.416622842094122 2867 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2498 4'-Methoxychalcone 54.63 µM -0.211100066691082 0.43730680836585 no 1915 0.416404594095571 2791 641818 YHR062C RPP1 SGTC_808 0711-0032 135 µM -0.211519871809088 0.437129977582098 no 1916 0.416240813760931 2744 4252555 SGTC_1884 5633444 25 µM -0.213612158394868 0.436248850240002 no 1917 0.415424758606136 2925 5724239 SGTC_2681 menadione 3.18 µM -0.214437744702855 0.435901256793545 no 1918 0.41510285507432 2841 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_517 1365-0151 113 µM -0.214872713280312 0.435718143531685 no 1919 0.414933279818003 2955 768657 SGTC_2210 7115885 190.385 µM -0.215485268541602 0.43546029312676 no 1920 0.414694498149459 2792 2927039 SGTC_1038 k292-0204 154 µM -0.216941238419069 0.434847524164058 no 1921 0.414127069600167 2764 4454212 SGTC_1078 idebenone 36.1 µM -0.217075825833106 0.434790888706117 no 1922 0.414074626487126 2865 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3343 9148379 18.9835 µM -0.217966893885307 0.434415953966601 no 1923 0.413727453052681 2938 1955036 SGTC_2492 derrusnin 100 µM -0.218489727384969 0.434195988729533 no 1924 0.413523780674152 2740 1715307 Part of coumarin class of compounds. SGTC_614 0462-0418 107 µM -0.219615647015883 0.433722363826367 no 1925 0.413085252172821 2820 5188303 SGTC_3093 9117344 49.47 µM -0.22179425878572 0.432806188366603 no 1926 0.412237024492536 2954 24824913 SGTC_3132 9126706 49.47 µM -0.221815362130181 0.432797315497729 no 1927 0.412228810046524 3011 850858 SGTC_1444 4112-3581 28 µM -0.223153367745228 0.432234822448569 no 1928 0.41170807196807 2796 2877249 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.224582304652942 0.431634253858326 no 1929 0.411152116049733 2966 23847180 SGTC_1818 st052136 56.3 µM -0.225989638084792 0.431042919415764 no 1930 0.410604739742254 2879 674169 SGTC_177 1327-0068 8.361 µM -0.226423942875654 0.430860464039368 no 1931 0.410435853853225 2804 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3044 9093193 49.47 µM -0.226927972753307 0.430648735024499 no 1932 0.410239875147475 2915 25236277 SGTC_769 0302-0231 76 µM -0.227378019550969 0.430459699652682 no 1933 0.41006490527722 2897 571869 YER009W NTF2 SGTC_2163 5671233 125 µM -0.229325254471594 0.429641977154335 no 1934 0.409308063107088 2999 701023 SGTC_1117 retinoic acid 1.10837 µM -0.231093580136129 0.428899647212105 no 1935 0.408621051229503 2971 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_305 1682-2595 20.8 µM -0.231347212588025 0.428793194754243 no 1936 0.408522535501787 2871 226033 SGTC_14 0354-0009 295 µM -0.233551702509879 0.427868163954596 no 1937 0.407666513282213 2793 1713507 SGTC_1285 0929-0069 65.5 µM -0.234605395101181 0.427426161386616 no 1938 0.407257510864617 2850 1206237 SGTC_151 3013-0144 2.285 µM -0.235598906482094 0.427009487022256 no 1939 0.406871961038766 3037 906558 YHR107C CDC12 SGTC_2290 7904846 200 µM -0.235881209766856 0.426891105084402 no 1940 0.406762424657064 2903 2962154 SGTC_1929 genistein trimethyl ether 50.5 µM -0.236315967462289 0.426708805321799 no 1941 0.406593748770679 3010 136420 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.237287414920942 0.426301520933209 no 1942 0.406216912388449 2999 688751 SGTC_304 1310-0298 97 µM -0.237373823562257 0.426265297461536 no 1943 0.406183397618317 2837 1550234 SGTC_288 1315-0019 35.1 µM -0.237570723506784 0.426182757120391 no 1944 0.406107029857458 2902 6811474 SGTC_2272 7805186 180 µM -0.237676475026208 0.426138427480009 no 1945 0.406066015541938 2953 2956062 YPR165W RHO1 SGTC_1342 1486-1464 234 µM -0.238004883674545 0.426000768863452 no 1946 0.405938653203831 2823 3253938 SGTC_2322 7413319 38.22 µM -0.240791274972501 0.424833165373029 no 1947 0.404858446129048 2960 1840400 SGTC_1432 4049-0298 68.4 µM -0.24098027232729 0.424753992079518 no 1948 0.404785203215008 2939 741646 SGTC_59 0330-0160 1.33 µM -0.241741477690237 0.424435144647489 no 1949 0.404490244001099 2855 4293482 SGTC_3189 9110682 49.47 µM -0.241782113614672 0.424418124794571 no 1950 0.404474499524723 2929 17122418 SGTC_84 0443-0269 128.823 µM -0.242059507796406 0.42430194544857 no 1951 0.404367026685438 2831 6150058 SGTC_618 k072-0232 33.2 µM -0.242096815493104 0.424286320590671 no 1952 0.404352572844332 2927 5872756 YGL099W LSG1 SGTC_2846 9008642 19.48 µM -0.242687221753443 0.424039068063459 no 1953 0.404123853567875 2975 2992898 SGTC_2728 chlorpromazine 9.18 µM -0.244811140061076 0.423149853564161 no 1954 0.403301333913326 2802 2726 A thorazine and dopamine antagonist. SGTC_1363 1636-0063 10.4 µM -0.247353766931836 0.422085854614856 no 1955 0.402317225611864 2853 6072185 SGTC_3025 9087895 49.47 µM -0.248238070740619 0.421715937735066 no 1956 0.401975105901471 2972 17173641 SGTC_2352 9027995 87.8 µM -0.249134516285325 0.421341012291097 no 1957 0.40162836544078 2903 2997347 SGTC_1756 st041558 35.5 µM -0.249781221163919 0.421070581542445 no 1958 0.401378271430431 3038 3955792 SGTC_1389 3405-0187 19 µM -0.249973328194806 0.420990255856671 no 1959 0.401303987488145 2887 799890 SGTC_2519 cryptotanshinone 88.04 µM -0.250694428077702 0.420688771833467 no 1960 0.401025184448133 3001 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1331 1472-0049 76.2 µM -0.251373263932224 0.420405000440814 no 1961 0.400762768244897 2837 24051409 SGTC_394 menadione 8.33 µM -0.251801700606473 0.420225923828937 no 1962 0.400597171386389 2973 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2288 7946289 167.31 µM -0.253052218978252 0.419703330664485 no 1963 0.400113930546575 3038 1246052 SGTC_187 1488-2104 32.728 µM -0.253228147832494 0.419629821118813 no 1964 0.400045958185661 2916 2852859 SGTC_3188 9110789 49.47 µM -0.255956575406394 0.418490144285865 no 1965 0.398992184187191 3017 849217 SGTC_710 3448-4187 58 µM -0.256012691133063 0.418466711631869 no 1966 0.398970518852436 2900 3946412 SGTC_2884 9058502 51.95 µM -0.256076011324256 0.418440270904432 no 1967 0.398946072369309 2963 6471554 SGTC_1108 betulinic acid 729.144 nM -0.25625296803886 0.418366380721541 no 1968 0.398877755515672 2890 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1124 fisetin 1.16336 µM -0.256888904657269 0.418100862330387 no 1969 0.398632268015498 2915 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1985 st071382 65.5 µM -0.258831141298523 0.41729016472061 no 1970 0.397882764565817 2878 6123237 SGTC_1691 st019933 84.6 µM -0.259542871874639 0.416993173252339 no 1971 0.397608203985374 2916 6176082 SGTC_1182 1222-0449 220 µM -0.259673192936084 0.416938797907248 no 1972 0.397557936200605 2929 658318 SGTC_2940 9060638 45.86 µM -0.260484974500174 0.416600124826613 no 1973 0.397244851998544 2976 4027022 SGTC_2148 5546263 113.568 µM -0.261708505555049 0.41608978799508 no 1974 0.396773091273113 2849 792097 SGTC_2694 st077685 81.9 µM -0.265134626988619 0.414661502288797 no 1975 0.395452876546782 2836 2838096 SGTC_1610 st001799 48.1 µM -0.265514042610493 0.414503400040911 no 1976 0.3953067467579 2840 621897 SGTC_2154 5570129 200 µM -0.266140089567182 0.414242556965958 no 1977 0.395065660492765 2880 673366 SGTC_1916 st067606 49.2 µM -0.267932456222977 0.413495975174528 no 1978 0.394375655152831 2963 19590279 SGTC_1600 coumarin 106 71.1 µM -0.267962253962499 0.413483566035132 no 1979 0.394364186745 3045 100336 A hepatotoxic, DNA x-linker. SGTC_623 k072-0108 16.9 µM -0.268771987821159 0.413146389001389 no 1980 0.39405257543503 2952 5382803 SGTC_2467 5474540 200 µM -0.270198330465122 0.412552609069008 no 1981 0.393503838520538 2870 5413519 SGTC_1606 st000094 49.2 µM -0.270682518858018 0.412351089068365 no 1982 0.393317611490947 3022 1242210 SGTC_2225 6654152 15.4 µM -0.270992534978533 0.412222071981871 no 1983 0.393198386870833 2937 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_572 0960-0087 17.7 µM -0.272594045383121 0.411555734760864 no 1984 0.392582644875327 2915 6796365 SGTC_188 3229-0966 278.469 µM -0.273324769350793 0.411251788509664 no 1985 0.392301788391148 2954 5722370 SGTC_3147 9097027 49.47 µM -0.274931110083198 0.410583815009655 no 1986 0.391684582702172 2911 25236841 SGTC_611 3453-1652 23.7 µM -0.275831440591157 0.410209538879892 no 1987 0.391338767014285 2995 1560575 SGTC_2730 imipramine 71.33 µM -0.276081250829178 0.410105704817717 no 1988 0.391242830458693 2902 3696 A tricyclic antidepressant. SGTC_2871 9038510 12.99 µM -0.276348320137679 0.409994703963506 no 1989 0.391140273086848 3090 4945164 SGTC_3003 9075612 71.4286 µM -0.276420311502348 0.409964783739658 no 1990 0.391112628954377 2971 6501993 SGTC_3045 9092950 49.47 µM -0.276983833191603 0.409730597454152 no 1991 0.390896259959642 3019 44120432 SGTC_2539 epi(13)torulosol 80 µM -0.277278824283675 0.409608018968156 no 1992 0.390783009056818 3003 6708597 SGTC_166 k072-0058 166.424 µM -0.278496300951406 0.409102211038893 no 1993 0.390315702093033 2985 5846229 SGTC_1195 1502-0147 41.1 µM -0.278577307341837 0.409068561811411 no 1994 0.39028461483155 2906 817940 SGTC_2700 st077718 96.8 µM -0.279389239326287 0.408731330612036 no 1995 0.38997306410167 2946 904970 SGTC_2453 5731132 22.18 µM -0.280232901195146 0.40838099216454 no 1996 0.389649412994151 3054 1362040 SGTC_2993 9054257 71.4286 µM -0.280921759782588 0.408094991502881 no 1997 0.389385205267758 2890 6470217 YGL055W OLE1 SGTC_1596 piperlongumine 63 µM -0.28096019436293 0.408079035654691 no 1998 0.389370465411505 3055 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1878 temozolomide 1 mM -0.281338602042852 0.407921950485484 no 1999 0.389225352650545 2995 5394 DNA alkylating agent. SGTC_3135 9127742 49.47 µM -0.282453276016018 0.407459311436721 no 2000 0.388797984423809 2962 3643468 SGTC_974 1326-0144 138 µM -0.283499689796595 0.40702512080782 no 2001 0.388396909709464 2924 5411856 SGTC_2190 6049624 200 µM -0.283972700017959 0.406828891159285 no 2002 0.38821565100051 2964 2265554 SGTC_1291 0993-0025 5.79 µM -0.286360949603606 0.405838477108007 no 2003 0.387300840285409 3036 4353356 SGTC_2958 9077254 16.72 µM -0.286871287315638 0.405626916475723 no 2004 0.387105438135104 3106 16457351 SGTC_1524 corynanthine 62.1 µM -0.287123841651454 0.405522230201449 no 2005 0.387008748705982 3087 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2485 5633444 17.78 µM -0.287946471897751 0.405181288705558 no 2006 0.386693856608647 3011 5724239 SGTC_960 1222-0186 7.7 µM -0.289071990470229 0.404714930867638 no 2007 0.386263143687516 3031 3126296 SGTC_894 0960-0238 55.9 µM -0.290204448694333 0.404245834158309 no 2008 0.385829916515466 2979 6741907 YDL195W SEC31 SGTC_2159 5658611 73.75 µM -0.290901102354541 0.403957328546964 no 2009 0.385563479100025 3018 793844 SGTC_2432 5630864 12.22 µM -0.292558611295313 0.403271113611945 no 2010 0.384929776776097 3055 5714970 SGTC_145 3737-0113 38.366 µM -0.294681565061365 0.40239263791389 no 2011 0.384118573557179 3054 6849351 SGTC_1014 4130-3005 69.3 µM -0.295244545096857 0.402159759928795 no 2012 0.383903537866098 2911 743608 SGTC_203 k066-0004 30.888 µM -0.29610983882196 0.401801896921348 no 2013 0.383573100227548 2984 6795412 SGTC_1799 st045822 46.1415 µM -0.296229692111255 0.40175233519855 no 2014 0.383527337424214 3072 3674992 SGTC_1334 1486-0610 236 µM -0.296564641516378 0.401613835327576 no 2015 0.383399454484343 3017 3742339 SGTC_652 0437-0092 114 µM -0.296854647306071 0.401493929393354 no 2016 0.383288741176896 2942 3091274 SGTC_2036 5160441 105 µM -0.298651709925789 0.400751122229208 no 2017 0.382602903073177 2991 134534 YIL048W NEO1 SGTC_2009 4012297 12.05 µM -0.299974869127967 0.400204429893791 no 2018 0.382098162455562 3046 45595307 SGTC_189 3970-0742 2.116 µM -0.300725287115258 0.399894464998125 no 2019 0.38181199225851 2962 2891807 SGTC_1284 0929-0043 16 µM -0.300865307786203 0.399836635550155 no 2020 0.381758602837288 2987 1239883 SGTC_2776 terbinafine 19.92 µM -0.303114914519919 0.398907835343844 no 2021 0.38090114418716 2977 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2842 9000675 19.48 µM -0.304949512432749 0.398150804043188 no 2022 0.380202302549146 2995 2989072 SGTC_2869 9037858 32.47 µM -0.305152388055621 0.398067112615342 no 2023 0.380125046399462 2911 27187042 SGTC_2490 carminic acid 95.39 µM -0.305238176533989 0.398031724065595 no 2024 0.380092379115093 2909 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_516 3992-2719 87.3 µM -0.305343131471644 0.397988430313033 no 2025 0.380052414622788 2876 5350887 YDR037W KRS1 SGTC_496 calpeptin 138 µM -0.307641587040197 0.397040636707184 no 2026 0.37917753599237 2999 73364 A calpain inhibitor. SGTC_917 harmaline 728.087 nM -0.30826482943615 0.396783740314538 no 2027 0.378940412899713 3050 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2206 7254556 146.969 µM -0.30841299019951 0.396722676013393 no 2028 0.378884049334242 2990 4398905 SGTC_2766 oltipraz 83.91 µM -0.30926037336764 0.396373476648999 no 2029 0.378561735933393 3100 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1312 1218-2183 165 µM -0.310791625916977 0.395742671524039 no 2030 0.377979518102596 2957 6744073 SGTC_1474 0330-0125 5.35 µM -0.310909291864748 0.395694209877179 no 2031 0.377934790218115 2987 X1474 SGTC_378 3970-0959 8.33 µM -0.311369717424723 0.395504595492332 no 2032 0.377759786231322 3078 6615653 SGTC_851 0394-0702 453 µM -0.312101460641707 0.395203296837936 no 2033 0.37748170825524 3087 762646 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.312956260913286 0.394851408212761 no 2034 0.377156946407975 2945 364106 SGTC_2943 9068529 45.32 µM -0.313491520186632 0.39463110605646 no 2035 0.376953631081593 2938 3270634 SGTC_1731 st035964 63 µM -0.314942407283184 0.394034119181952 no 2036 0.376402691210311 2971 6739575 SGTC_37 0566-0070 1.56 µM -0.315844236428971 0.393663174876325 no 2037 0.376060369815194 3049 1626686 SGTC_3002 9075603 71.4286 µM -0.316790523199466 0.393274047798168 no 2038 0.375701277768176 2969 20105405 SGTC_704 1310-0270 142 µM -0.318614846532475 0.392524160285976 no 2039 0.375009296929844 3034 5718033 SGTC_1297 1068-0111 14.1 µM -0.318783066119764 0.392455033721497 no 2040 0.374945510074089 2966 767057 SGTC_1669 st015249 58.4 µM -0.319000603076489 0.392365646175318 no 2041 0.374863027733578 3064 722793 SGTC_1423 4048-0112 5.59 µM -0.319779128680743 0.392045790797939 no 2042 0.374567885206928 3053 X1423 SGTC_3143 9086658 49.47 µM -0.320343942609555 0.391813783989244 no 2043 0.3743538077048 3021 25236626 SGTC_141 0443-0274 32.331 µM -0.320826548773342 0.391615575873915 no 2044 0.374170919523788 3112 1627241 SGTC_3259 9138485 49.47 µM -0.322016879310907 0.391126823140133 no 2045 0.373719953606635 3289 17646153 SGTC_2100 5377183 190 µM -0.322337330359387 0.390995274461379 no 2046 0.373598577754245 3049 2844202 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.322809763815104 0.39080135808312 no 2047 0.373419659053948 2997 4330530 SGTC_955 1216-0110 33 µM -0.323238448901094 0.390625422279987 no 2048 0.373257332226325 2923 3619719 SGTC_1689 st020265 53.493 µM -0.323807598237748 0.390391873421633 no 2049 0.373041851657936 3103 5758320 YPR016C TIF6 SGTC_2887 9044784 58.44 µM -0.323871780086673 0.390365539056903 no 2050 0.373017554829174 2988 6465546 SGTC_621 3584-0052 32.1 µM -0.324371458082785 0.390160534087469 no 2051 0.372828412853199 3089 2273927 SGTC_2396 5342950 42.78 µM -0.325354184719495 0.389757435895341 no 2052 0.372456513041326 3065 1886677 SGTC_1278 0874-0585 172 µM -0.326264198920108 0.38938426884442 no 2053 0.372112236296171 3052 766306 SGTC_2231 micatex 6.853 µM -0.327213084053011 0.388995270705151 no 2054 0.371753362740258 3032 20737 An antifungal of unknown mechanism. SGTC_548 1436-0017 110 µM -0.327708747813091 0.388792116156146 no 2055 0.371565944269973 3131 9677137 SGTC_2072 5231554 129 µM -0.327927800044511 0.388702344298219 no 2056 0.37148312678124 3096 789545 SGTC_1122 capsaicin 818.572 nM -0.327934108129546 0.388699759210501 no 2057 0.371480741959782 3114 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_845 0330-0138 4.51 µM -0.329380629515562 0.388107097210933 no 2058 0.370934003547807 3046 9039800 SGTC_539 4859-0462 2.54 µM -0.329991821503617 0.387856760683345 no 2059 0.370703070904983 3142 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2755 lomerizine 42.69 µM -0.332308430213103 0.386908330868658 no 2060 0.369828187438026 3025 3949 A calcium channel blocker. SGTC_1317 1273-0028 910 nM -0.332721647439417 0.386739228681804 no 2061 0.369672203699541 3001 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2913 7966556 36.57 µM -0.332911842774024 0.386661401669969 no 2062 0.369600414819249 3123 2976516 SGTC_3108 9121785 49.47 µM -0.33299122630888 0.386628919659182 no 2063 0.369570452993943 2916 17140271 SGTC_2564 betulinic acid 100 µM -0.333298528540226 0.386503185779993 no 2064 0.369454475003115 3272 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1783 st039459 87.517 µM -0.333664848590916 0.386353320102888 no 2065 0.369316238798416 3190 729761 SGTC_1260 0700-1617 7.75 µM -0.333836960238259 0.386282913132807 no 2066 0.369251295795221 3109 2853078 SGTC_2379 9035213 200 µM -0.33461442951021 0.385964914783117 no 2067 0.368957979316417 3147 646551 SGTC_2709 st078560 56 µM -0.335995951551868 0.385400037556435 no 2068 0.368436959690931 3166 17250903 SGTC_1310 1188-0297 994 nM -0.33662199984289 0.385144138651907 no 2069 0.368200934840227 3033 1588352 SGTC_1506 4226-2149 212 µM -0.336727648103668 0.385100959572931 no 2070 0.368161109564483 3101 991114 SGTC_762 1165-0429 115 µM -0.337146966964922 0.384929595487941 no 2071 0.368003056674842 3125 5967793 SGTC_1827 berberine 7.24 µM -0.337292583491935 0.384870091274312 no 2072 0.367948174999153 2994 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2326 6164455 177.58 µM -0.33733391145279 0.384853203659034 no 2073 0.367932599320414 3056 2888790 SGTC_36 0335-0881 14.2 µM -0.338194803699446 0.384501471752487 no 2074 0.367608195724711 3009 23828853 SGTC_3295 9122362 53.5725 µM -0.338375508191923 0.384427653975619 no 2075 0.367540114184944 3095 4730473 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.339301370773682 0.384049504951732 no 2076 0.367191355053917 3320 5282309 SGTC_3029 9088683 49.47 µM -0.340247726091009 0.383663100150102 no 2077 0.366834989813855 3139 25236615 SGTC_1642 st009582 77.7 µM -0.340534635814004 0.383545975337587 no 2078 0.366726972017137 3152 6739311 SGTC_809 3998-0021 90 µM -0.340592792489626 0.383522235404228 no 2079 0.366705078067697 3159 715485 SGTC_1684 st024538 14.6195 µM -0.342369314385603 0.38279725869696 no 2080 0.366036489124615 3013 6732859 SGTC_2606 farnesol 9.78 µM -0.343126487913292 0.38248839010409 no 2081 0.365751652479252 3172 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_307 1501-1223 22.3 µM -0.343242680636052 0.382440999015189 no 2082 0.365707949168835 3095 2830329 SGTC_1504 k297-0033 30 µM -0.344165460445134 0.382064690854464 no 2083 0.365360927981234 2960 4388117 SGTC_1213 1315-0166 115 µM -0.344722212899899 0.381837701927343 no 2084 0.365151608565063 3114 768401 SGTC_2068 5226020 147 µM -0.344975229199167 0.381734560169302 no 2085 0.365056496573593 3055 1810509 SGTC_903 1134-0042 114 µM -0.347543120368902 0.380688238926746 no 2086 0.36409166475833 3034 701009 SGTC_1225 1216-0074 20.6 µM -0.349400628555434 0.37993191570971 no 2087 0.363394280751991 3042 4241466 SGTC_3072 9116419 49.47 µM -0.349899628486119 0.379728815570354 no 2088 0.363207012927574 3067 17170162 SGTC_2951 9072950 58.06 µM -0.350840131115585 0.379346107717997 no 2089 0.362854144114792 3054 16488155 SGTC_1578 josamycin 24.2 µM -0.352509924430914 0.378666929477453 no 2090 0.362227938461438 3028 5282165 A P450 substrate. SGTC_1347 1493-0251 600 nM -0.352879281398216 0.378516746301891 no 2091 0.362089471979615 3156 3986378 SGTC_1240 0356-0016 42.1 µM -0.353394926669548 0.378307111948946 no 2092 0.361896194355854 3058 4305613 SGTC_1993 st073995 70.8 µM -0.35565731594101 0.377387767052137 no 2093 0.361048607237426 3032 3098394 SGTC_2885 9057732 51.95 µM -0.356296797743289 0.377128032765135 no 2094 0.360809153608038 3172 6471414 SGTC_713 1488-1073 324 µM -0.357184114691201 0.376767728930423 no 2095 0.360476988617204 3041 3312542 SGTC_950 1165-0508 94.1 µM -0.358338909123425 0.376298973954255 no 2096 0.360044851735005 3105 6148369 SGTC_1552 6-methylflavone 10.6 µM -0.358430966462067 0.376261613814762 no 2097 0.360010410545629 3117 689013 SGTC_728 3030-5151 22.5 µM -0.358492634209587 0.376236587499749 no 2098 0.359987339576047 3031 3125388 SGTC_2054 5233173 129 µM -0.359549251268402 0.375807866781011 no 2099 0.359592120182576 3180 6889 SGTC_2112 5488546 200 µM -0.360014716477907 0.375619053599009 no 2100 0.359418064149422 3013 600757 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.360093699951668 0.375587017379231 no 2101 0.359388531967309 3005 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1874 staurosporine 7.6 µM -0.36048482953085 0.375428385278402 no 2102 0.359242299705241 3156 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_982 1491-0518 27.5 µM -0.360639028748033 0.375365851827253 no 2103 0.359184654654205 3030 3091256 SGTC_1286 0929-0070 131 µM -0.36071044732219 0.375336890079524 no 2104 0.359157956983795 3154 1420408 SGTC_3191 9110352 49.47 µM -0.360945519685801 0.3752415682099 no 2105 0.359070087159934 3090 17122424 SGTC_1795 st049545 62.3 µM -0.361017091950373 0.37521254716118 no 2106 0.359043334996459 3163 5291882 SGTC_147 4466-0538 29.23 µM -0.362648117704639 0.374551392258727 no 2107 0.358433880464953 3258 6742687 YHR072W ERG7 SGTC_1352 1496-0991 99 µM -0.364891727892406 0.373642521918388 no 2108 0.357596114699806 3043 3000039 SGTC_3324 9138759 60.749 µM -0.365402084377167 0.373435878042465 no 2109 0.357405642776949 3175 45595710 SGTC_2086 5274770 176.623 µM -0.365596721472788 0.37335707886057 no 2110 0.357333010941159 3116 689278 SGTC_2082 5219693 150 µM -0.366677440255565 0.372919644317298 no 2111 0.356929818132062 3025 2834649 SGTC_556 4058-0063 51.5 µM -0.367068737744488 0.372761302089207 no 2112 0.356783872868911 3099 6615692 SGTC_701 4424-0219 185 µM -0.367283332021875 0.372674473611953 no 2113 0.356703842873402 3220 2911779 SGTC_1024 4507-0395 26 µM -0.367801272488752 0.372464932790483 no 2114 0.35651071006243 3213 4201836 SGTC_357 1325-0123 420 µM -0.368212979669396 0.372298397210412 no 2115 0.356357216410857 3170 1098503 SGTC_68 0986-0284 82.829 µM -0.368525668495929 0.372171930513638 no 2116 0.356240654562956 3208 423278 YIL048W NEO1 SGTC_1177 0983-0204 23.6 µM -0.368989490068468 0.371984363717681 no 2117 0.356067779298586 3198 766818 SGTC_3089 9117425 49.47 µM -0.36942793934888 0.371807085259 no 2118 0.355904387978333 3113 9401657 SGTC_1131 3454-3128 32.3 µM -0.370056564923115 0.371552960130954 no 2119 0.355670172252943 3201 710982 SGTC_354 2783-3500 4.88 µM -0.370277184301083 0.371463786873337 no 2120 0.355587985950389 3070 6740761 SGTC_2128 5255449 168.493 µM -0.371773701075832 0.370859084541036 no 2121 0.355030672971423 3055 736008 SGTC_914 3820-6779 408 µM -0.372929366013536 0.370392329370679 no 2122 0.354600507587921 3007 2893481 SGTC_570 0987-0065 62.6 µM -0.373054992301726 0.370341602341189 no 2123 0.354553757720661 3023 3104428 SGTC_1399 3562-5772 25 µM -0.373251121408712 0.370262411267465 no 2124 0.354480775707554 3004 23847490 SGTC_2872 9044037 25.97 µM -0.373801134155024 0.370040361894982 no 2125 0.354276137817971 3042 6465195 SGTC_2930 9013230 14.89 µM -0.374190390776594 0.369883238636182 no 2126 0.354131336313793 3179 2995857 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.375740806819356 0.369257629665748 no 2127 0.353554798823096 3106 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_197 4544-0043 41.561 µM -0.377706975792786 0.368464757983524 no 2128 0.352824142554559 3067 896523 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.379498260602112 0.367742896721835 no 2129 0.352158947845788 3104 6708561 SGTC_404 fumagillin 50 µM -0.380153526731828 0.367478950680519 no 2130 0.351915727196096 3136 12015870 A methionine aminopeptidase binder. SGTC_1634 st006576 41 µM -0.380424654129848 0.367369756860544 no 2131 0.351815108269024 3245 3915356 SGTC_317 4495-0002 170 µM -0.381876081943389 0.366785391540615 no 2132 0.351276641039222 3112 15991618 SGTC_2455 5377712 9.75 µM -0.38234562198039 0.36659641409328 no 2133 0.351102509553624 3137 2243908 SGTC_1199 1638-0010 4.46 µM -0.38314170477872 0.366276085728045 no 2134 0.350807349345662 3079 3111136 SGTC_3196 9111891 49.47 µM -0.383358383432151 0.366188914535887 no 2135 0.350727027907338 3086 18891510 SGTC_1126 isoteolin 1.0172 µM -0.385944919969465 0.36514886889374 no 2136 0.349768730861908 3064 133323 SGTC_1766 st045414 44.774 µM -0.386991533252285 0.364728307203258 no 2137 0.349381238023096 3102 253960 SGTC_3281 9140613 49.47 µM -0.387711688333774 0.364439021021717 no 2138 0.349114702536417 3121 16013766 SGTC_2927 9011802 47.9 µM -0.387908314573926 0.36436004970115 no 2139 0.349041942428607 3172 43912568 SGTC_3013 9080133 71.4286 µM -0.388131170119684 0.364270550822306 no 2140 0.348959483066662 3309 17050193 SGTC_3 0833-0587 95.581 µM -0.389544884578202 0.363702975076157 no 2141 0.34843655716343 3143 5382644 SGTC_1962 st076595 64.5 µM -0.390133537750821 0.363466731661615 no 2142 0.348218902146445 3097 279619 SGTC_901 1112-0062 60.1 µM -0.390275993760047 0.363409567774763 no 2143 0.34816623642319 3095 1908457 SGTC_2996 9066192 71.4286 µM -0.390596776770364 0.363280857043457 no 2144 0.348047654258653 3124 6472854 SGTC_1140 3229-1848 2.98 µM -0.392702990126756 0.362436145598584 no 2145 0.347269430966353 3197 2849525 SGTC_2438 5259590 200 µM -0.392931301574159 0.36234461984659 no 2146 0.347185110930994 3187 1201127 SGTC_3141 9094609 49.47 µM -0.394139853394574 0.361860265392225 no 2147 0.346738894382396 3035 25236309 YDL196W YDL196W SGTC_384 k007-0144 5.16 µM -0.394182337423698 0.361843242977373 no 2148 0.346723212466383 3143 6824886 SGTC_2370 9071495 200 µM -0.395445160922295 0.361337382363824 no 2149 0.34625719280396 3173 21791103 SGTC_817 1391-0715 46 µM -0.396191047307012 0.361038709696663 no 2150 0.345982047661067 3138 1353946 SGTC_1628 st004252 77.7 µM -0.396784691795991 0.360801059243097 no 2151 0.345763120127992 3223 692968 SGTC_3015 9080845 49.47 µM -0.396914400518275 0.36074914080978 no 2152 0.345715292281914 3230 5296973 SGTC_1033 k072-0102 21.3 µM -0.399451147537152 0.359734275553648 no 2153 0.344780406542116 3257 5965931 SGTC_2800 7887935 81.82 µM -0.401770379679755 0.358807294991655 no 2154 0.343926511552246 3235 2961002 SGTC_3234 9132280 49.47 µM -0.401855590019985 0.358773252819596 no 2155 0.343895153928481 3173 17612295 SGTC_2185 6113692 200 µM -0.404476904181125 0.357726567350376 no 2156 0.342931029101448 3234 874150 SGTC_149 3970-0822 46.1 µM -0.405733824313987 0.357225060335628 no 2157 0.342469093309769 3246 3114250 YBL034C STU1 SGTC_630 4356-0227 183 µM -0.407930475131124 0.356349196201329 no 2158 0.341662359127883 3185 779312 SGTC_1793 st048256 72.231 µM -0.408304932867443 0.356199965183343 no 2159 0.341524909105874 3112 672022 SGTC_2227 7312221 64.1025 µM -0.408326449801499 0.356191390801769 no 2160 0.341517011648387 3142 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_870 0573-2213 57.6 µM -0.408451056310944 0.356141737213266 no 2161 0.341471278122948 3188 3916321 SGTC_1557 sumaresinolic acid 42.3 µM -0.40946502222525 0.355737779686349 no 2162 0.341099215321663 3114 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3026 9090633 49.47 µM -0.410412399681052 0.355360496902273 no 2163 0.340751725923151 3119 25236842 SGTC_327 1273-0057 3.96 µM -0.411055282013053 0.355104556678758 no 2164 0.340515999474341 3140 3108138 SGTC_1111 tnp00062 510.699 nM -0.411367780790052 0.354980170253218 no 2165 0.340401437658094 3283 676306 SGTC_1979 st071809 45.3 µM -0.413887413889151 0.353977825909395 no 2166 0.339478280900856 3255 4976333 SGTC_230 MPP+ 141.667 µM -0.415159306942721 0.353472233110829 no 2167 0.339012643013734 3183 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3344 9148862 3.898 µM -0.41615745562785 0.353075637923223 no 2168 0.338647394589723 3280 4905352 SGTC_605 1315-0399 119 µM -0.417538062637723 0.352527343293708 no 2169 0.33814244484057 3272 24020461 SGTC_881 0833-0569 170 µM -0.420296980043889 0.351432584570476 no 2170 0.337134257890193 3160 5418700 SGTC_488 nitrendipine 139 µM -0.420472139444525 0.351363121506115 no 2171 0.337070289036949 3185 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1022 4477-0945 21.3 µM -0.421422196647459 0.350986443312574 no 2172 0.336723406791139 3142 4648966 SGTC_1651 st011928 86.1 µM -0.421611942180062 0.350911230626781 no 2173 0.336654144056764 3241 720198 SGTC_3237 9133362 49.47 µM -0.421927836220245 0.350786027255733 no 2174 0.336538845675811 3229 43845137 SGTC_2675 theaflavin digallate 100 µM -0.42260292352562 0.350518513361294 no 2175 0.336292496621672 3219 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1369 1866-0067 208 µM -0.423015933695181 0.350354888161605 no 2176 0.336141817919328 3289 3531355 SGTC_662 k832-1615 104 µM -0.423048457305113 0.350342004228958 no 2177 0.336129953432565 3224 5878478 SGTC_835 0312-0010 67.2 µM -0.423313941480917 0.350236841525427 no 2178 0.336033111940639 3116 1626196 SGTC_1755 st041960 45.185 µM -0.423942326018594 0.349987973707865 no 2179 0.335803937524619 3259 2257073 SGTC_214 4373-3496 70 µM -0.424445351719595 0.349788799903885 no 2180 0.33562052597811 3258 3779166 SGTC_1964 st076914 61 µM -0.424581625413458 0.349734849236997 no 2181 0.335570845059226 3195 24208661 SGTC_1674 st016616 23.6 µM -0.425316169938092 0.349444095817714 no 2182 0.335303103742493 3096 625830 SGTC_367 0335-0881 7.1 µM -0.426305069302027 0.349052801088232 no 2183 0.334942782251807 3297 23828853 SGTC_1378 2093-0007 380 nM -0.428175374784604 0.34831318426355 no 2184 0.334261721644192 3251 3618014 SGTC_2458 5808907 16.39 µM -0.428184185799234 0.348309701288583 no 2185 0.334258514454379 3297 2731747 SGTC_2355 9061122 103.12 µM -0.428916928643958 0.348020094423156 no 2186 0.333991840045183 3231 5302957 SGTC_534 k292-0788 63.4 µM -0.429540767825401 0.347773600118101 no 2187 0.333764866069896 3320 4146317 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.429560232512448 0.347765910172747 no 2188 0.333757785130698 3187 688664 SGTC_1984 st072354 53.1 µM -0.429599520360764 0.347750388849831 no 2189 0.333743493025518 3093 5762938 SGTC_1540 guanosine 70.6 µM -0.43172039221415 0.346912882175354 no 2190 0.332972322248365 3210 6802 Guanosine is a purine nucleoside SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.43291812940892 0.346440240150212 no 2191 0.332537124365324 3190 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2836 9010338 19.48 µM -0.434664905568144 0.345751369081801 no 2192 0.331902837705855 3155 2994051 SGTC_356 1634-0012 32.5 µM -0.434818216259083 0.345690932717561 no 2193 0.331847190722114 3284 735457 SGTC_3187 9109394 49.47 µM -0.435562192753032 0.345397706791594 no 2194 0.331577203230322 3196 17098090 SGTC_3174 9107204 49.47 µM -0.436803627016416 0.344908622788909 no 2195 0.331126884192924 3279 3938802 SGTC_500 h-89 112 µM -0.438407338657197 0.344277196997772 no 2196 0.330545513779666 3308 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_747 3448-8087 38.7 µM -0.439869487212723 0.343701886516408 no 2197 0.33001581825042 3194 5168703 SGTC_3272 9137413 49.47 µM -0.440435037508741 0.343479456830433 no 2198 0.329811026485621 3181 17614870 SGTC_2418 pentamidine 31.67 µM -0.440470137091037 0.343465654027279 no 2199 0.329798318234769 3271 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_481 bay k-8644 50 µM -0.440914244281408 0.343291028271353 no 2200 0.329637540543737 3203 2303 A calcium channel antagonist. SGTC_3350 9150499 3.57 µM -0.442284240741522 0.342752547906127 no 2201 0.329141766684743 3149 4910996 YPR165W RHO1 SGTC_905 2-aminofluorene 215 µM -0.443063555736711 0.342446378708787 no 2202 0.328859882391556 3211 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1777 st045864 34.765 µM -0.443509666309553 0.342271161980236 no 2203 0.328698564517283 3264 4691462 SGTC_794 k038-0031 316 µM -0.443696229937853 0.342197896336288 no 2204 0.328631110777306 3304 6624242 SGTC_1277 0873-0036 22 µM -0.444595533564962 0.34184481301082 no 2205 0.328306037906918 3284 5965735 SGTC_319 1348-1596 45.5 µM -0.444761534977851 0.341779652880364 no 2206 0.328246047283949 3337 5380505 SGTC_744 1594-0068 283 µM -0.444959221745267 0.341702061523911 no 2207 0.328174611788378 3183 668392 SGTC_2783 7738165 71.43 µM -0.445635271325289 0.34143676501491 no 2208 0.327930364045652 3225 17201110 SGTC_823 0417-1665 178 µM -0.446584710418004 0.341064316804474 no 2209 0.327587468538722 3244 3429856 SGTC_2600 tangeritin 87.95 µM -0.447415037588383 0.34073872098048 no 2210 0.327287710142451 3184 68077 A bioactive flavone. SGTC_1944 st076371 56.9 µM -0.44843780924575 0.340337825042122 no 2211 0.326918629957522 3166 24208455 SGTC_472 calcifediol 10 µM -0.449540567983636 0.339905778642539 no 2212 0.326520875034916 3238 5283731 A vitamin D metabolite. SGTC_2646 retinol 96.75 µM -0.449545181044277 0.339903971747024 no 2213 0.326519211560197 3279 445354 A vitamin A analog and teratogen. SGTC_15 0266-0086 27.098 µM -0.451178390587517 0.339264489276004 no 2214 0.325930491428781 3310 1712902 YIL048W NEO1 SGTC_1253 0550-0034 176 µM -0.451359663929861 0.339193540273402 no 2215 0.325865174864464 3287 5969915 SGTC_1036 k216-0215 33.5 µM -0.451908667247705 0.338978699355668 no 2216 0.325667390131509 3221 622330 SGTC_283 0987-0079 11.7 µM -0.452423717099638 0.33877719301246 no 2217 0.325481882129028 3298 411556 SGTC_2415 st077333 57.7 µM -0.453503733118022 0.338354801086295 no 2218 0.325093027911251 3408 2766255 SGTC_1530 rhein 70.4 µM -0.454571171218978 0.337937528125306 no 2219 0.324708889404011 3251 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2662 daunorubicin 22.37 µM -0.455716341219153 0.337490090265833 no 2220 0.324296984758019 3220 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_25 0118-0223 35.662 µM -0.456022162094716 0.337370639554746 no 2221 0.324187020802721 3347 5333628 SGTC_2868 9035608 32.47 µM -0.456474404996266 0.337194027839308 no 2222 0.324024436014359 3188 6462614 SGTC_711 k292-0785 179 µM -0.456807707098325 0.337063888322087 no 2223 0.323904632834524 3201 4146315 SGTC_459 nigericin 15.3 µM -0.458111024161671 0.336555188799648 no 2224 0.323436339559307 3329 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.459356809578203 0.336069223970928 no 2225 0.322988979183733 3219 2333 A French combination drug. SGTC_1323 1348-1351 11.2 µM -0.461204036023664 0.33534914903507 no 2226 0.322326113159049 3217 6989654 SGTC_2321 7390090 138.78 µM -0.46237176053178 0.334894265194422 no 2227 0.321907373386187 3233 649046 SGTC_1899 st063254 59.6 µM -0.464211637316454 0.334178037775583 no 2228 0.321248062194958 3163 3093813 SGTC_3283 9109332 35.8195 µM -0.465134668667961 0.333818947150183 no 2229 0.320917510166527 3215 17027281 SGTC_2031 5180455 200 µM -0.465603981836422 0.333636426667429 no 2230 0.320749496145005 3223 29949 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.465663905531927 0.333613124589229 no 2231 0.320728046116094 3307 616764 SGTC_2985 9022375 71.43 µM -0.466780937406444 0.33317887036194 no 2232 0.320328307814311 3380 4939335 SGTC_2945 9067681 61.76 µM -0.467599426829833 0.332860818551195 no 2233 0.320035537442843 3333 16456930 SGTC_2786 7743617 45.45 µM -0.468688256721704 0.332437903154218 no 2234 0.319646241043762 3214 583674 SGTC_789 1309-1135 70.6 µM -0.469345668247622 0.332182659343321 no 2235 0.319411288584925 3312 3092424 SGTC_1077 5-fluorocytosine 377 nM -0.470195043133927 0.331852999900634 no 2236 0.319107837629483 3296 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2136 5328288 199.296 µM -0.470384620362343 0.331779438929388 no 2237 0.319040125069826 3203 262395 SGTC_765 1319-0117 244 µM -0.470432272648382 0.331760949603796 no 2238 0.319023105735382 3221 3487746 YGL099W LSG1 SGTC_3255 9139072 49.47 µM -0.470607137005948 0.331693104868788 no 2239 0.318960655023031 3309 17646060 SGTC_1746 st038117 42 µM -0.470675237969901 0.331666684214701 no 2240 0.318936334969189 3294 2898218 SGTC_2654 protoveratrine a 100 µM -0.471000908359786 0.331540347733298 no 2241 0.318820043115233 3255 5702278 A heart drug and vasodilator. SGTC_3122 9126309 49.47 µM -0.471265549499291 0.331437700284716 no 2242 0.318725556997396 3334 17591206 SGTC_888 0916-0002 6.97 µM -0.471309847886901 0.331420519323459 no 2243 0.318709742078972 3369 2802138 YIL048W NEO1 SGTC_720 r052-1644 49.9 µM -0.472186915569786 0.331080425042159 no 2244 0.318396689131056 3320 1422863 YOR257W CDC31 SGTC_3113 9123498 49.47 µM -0.472446911241803 0.3309796351326 no 2245 0.318303913425118 3320 8897275 SGTC_1252 0493-0875 34.8 µM -0.472585169775421 0.330926042824166 no 2246 0.318254582502088 3203 3960963 SGTC_1707 st032323 6.317 µM -0.473410077935365 0.330606360760016 no 2247 0.317960320619617 3281 3132057 YMR211W DML1 SGTC_1163 k060-0048 49.9 µM -0.473746515673089 0.330476014292677 no 2248 0.317840339263568 3264 6809982 SGTC_2514 salinomycin 42.74 µM -0.476533607487598 0.329397000022877 no 2249 0.316847135197103 3362 23682228 A polyether potassium ionophore. SGTC_1001 4048-4355 44.4 µM -0.476590133654705 0.32937513073962 no 2250 0.316827005231638 3241 21824233 SGTC_1631 benzylvanillin 81.9 µM -0.47672180833359 0.329324189679056 no 2251 0.31678011565822 3332 75506 SGTC_2276 7947513 42.08 µM -0.476999483815812 0.32921677558716 no 2252 0.316681244603053 3275 2105100 SGTC_695 3505-6186 243 µM -0.47777447573492 0.32891705758851 no 2253 0.316405364907342 3329 1819379 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.477840502378642 0.328891527727944 no 2254 0.316381865626419 3372 1377 SGTC_1547 harmine 94.2 µM -0.478659653672734 0.328574861127528 no 2255 0.316090386418973 3294 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1005 4092-0690 4.4 µM -0.478986642852067 0.328448488369784 no 2256 0.315974065520334 3241 1529343 SGTC_1558 st069300 45.6 µM -0.480144391808828 0.328001206523654 no 2257 0.315562362310471 3327 24208000 SGTC_837 0091-0265 12.5 µM -0.480611008845514 0.327821004536311 no 2258 0.315396494862422 3222 759367 SGTC_2724 maprotiline 69.64 µM -0.481245227123958 0.32757614120186 no 2259 0.315171110164776 3364 4011 A tricyclic antidepressant. SGTC_951 1171-0579 82.7 µM -0.48185954492556 0.327339031865987 no 2260 0.314952863155614 3305 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1505 k297-0037 20.6 µM -0.481944222417855 0.327306354202988 no 2261 0.314922785078066 3233 4089396 SGTC_578 3460-0051 92 µM -0.482972634472108 0.326909588179404 no 2262 0.314557583466301 3392 2876744 SGTC_1287 0971-0001 34.6 µM -0.48397399069861 0.326523448351291 no 2263 0.314202163960096 3316 4665869 SGTC_761 k216-0224 480 µM -0.48549741353307 0.325936347290913 no 2264 0.313661773480106 3417 1340404 SGTC_106 0092-0003 11.579 µM -0.486177701002954 0.325674315366408 no 2265 0.313420590030718 3287 1072148 SGTC_1173 0443-0020 122 µM -0.48822887999012 0.324884767532158 no 2266 0.312693865253567 3259 5331295 SGTC_1315 1237-0019 3.69 µM -0.488720031841586 0.3246958279376 no 2267 0.31251995990771 3355 825140 SGTC_2698 st077697 67.5 µM -0.488802978977487 0.324663923726016 no 2268 0.312490594392026 3263 3154499 SGTC_1107 amlodipine 47 µM -0.491207150155773 0.32373975979164 no 2269 0.311639971154979 3317 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_325 2810-4341 181 µM -0.49260086072773 0.323204513883958 no 2270 0.311147319877525 3369 774970 SGTC_1883 5-benzylidenerhodanine 20 µM -0.494307253988115 0.322549682261157 no 2271 0.31054460144746 3345 1273210 SGTC_2936 9038235 15.59 µM -0.496064862471503 0.321875771716696 no 2272 0.30992432447922 3294 4749415 SGTC_665 3914-0008 307 µM -0.496272036417039 0.321796374634238 no 2273 0.309851246384696 3266 1069549 SGTC_1018 4259-0013 28.1 µM -0.496383334194122 0.321753724373397 no 2274 0.309811990546909 3351 6801262 SGTC_723 4182-0001 115 µM -0.497372274759775 0.321374857087855 no 2275 0.30946327661936 3282 744821 YLR208W SEC13 SGTC_3212 9128307 49.47 µM -0.499917464774563 0.320400639161885 no 2276 0.308566597116648 3148 27243542 SGTC_645 0845-0943 5.41 µM -0.501987731046149 0.319609118336921 no 2277 0.307838075650118 3310 1885106 SGTC_3049 9092223 49.47 µM -0.503480275570749 0.319038985772898 no 2278 0.307313322303912 3344 8623917 SGTC_2661 dactinomycin 12.96 µM -0.504819392999142 0.318527824405775 no 2279 0.306842846785856 3309 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_854 0422-0053 192 µM -0.504871360621418 0.318507994530863 no 2280 0.306824595274044 3370 3596728 SGTC_1697 st025554 27.742 µM -0.505080938332581 0.318428028863479 no 2281 0.306750994494554 3304 1269519 SGTC_297 0986-0032 24 µM -0.505404100414298 0.318304740957214 no 2282 0.306637519731504 3294 2847425 SGTC_3245 9134821 49.47 µM -0.505556297250622 0.318246684093109 no 2283 0.306584083927446 3283 17014901 SGTC_2364 9055074 200 µM -0.506464877152254 0.31790019096487 no 2284 0.306265170105083 3355 6470630 SGTC_3066 9117245 49.47 µM -0.50804810965838 0.317296795406886 no 2285 0.305709802225549 3301 17176980 SGTC_1844 rapamycin 4 nM -0.509043536658652 0.316917670404808 no 2286 0.305360853916312 3325 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2457 5731572 11.68 µM -0.510038689635732 0.316538841829513 no 2287 0.305012178366048 3394 2865357 SGTC_2164 5685496 200 µM -0.510983566141997 0.316179330212732 no 2288 0.304681282119668 3404 759046 SGTC_532 1548-0774 215 µM -0.511569438612855 0.315956501577898 no 2289 0.304476189482711 3500 5932993 SGTC_348 k064-0012 10.7 µM -0.511834219008697 0.315855817880706 no 2290 0.304383519661033 3307 5066323 SGTC_1758 st042942 75.2445 µM -0.513417718458054 0.315253971871492 no 2291 0.303829576980805 3383 669317 SGTC_802 4112-3352 742 µM -0.514847735020696 0.314710881559625 no 2292 0.303329712771966 3421 704594 SGTC_2431 5490079 200 µM -0.516225351598727 0.314188070414034 no 2293 0.302848512950738 3346 5722345 SGTC_2893 9048488 25.97 µM -0.517565442723496 0.313679857802186 no 2294 0.302380748957696 3323 6467338 SGTC_2187 6125751 200 µM -0.518674651545292 0.313259471618755 no 2295 0.301993820618953 3361 874498 SGTC_977 1348-1378 135 µM -0.520476811134707 0.312576976891347 no 2296 0.301365643040751 3324 X977 SGTC_1952 st077036 64.1 µM -0.520531803558037 0.312556160831699 no 2297 0.301346483620422 3391 2937007 SGTC_332 4112-0506 40.9 µM -0.521772091195329 0.312086838703573 no 2298 0.30091451180621 3348 2790355 SGTC_1153 4055-0057 267 µM -0.522719321408717 0.311728614113466 no 2299 0.300584795267432 3317 882706 SGTC_2495 cafestol 54.53 µM -0.522727508830202 0.311725518560966 no 2300 0.300581946060763 3446 16667697 An anti-infammatory. SGTC_2543 pimpinellin 60.67 µM -0.522948320341382 0.311642037755507 no 2301 0.30050510868619 3263 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_707 0865-0008 204 µM -0.523808419046827 0.311316958018395 no 2302 0.300205898544389 3337 723043 SGTC_2614 arthonioic acid 13.39 µM -0.524761332786413 0.310956969998078 no 2303 0.299874557394554 3369 6710684 SGTC_3109 9122853 49.47 µM -0.525241360398247 0.310775695512233 no 2304 0.299707707949399 3367 1234709 SGTC_867 0518-0118 155 µM -0.52719613834563 0.310037980575171 no 2305 0.299028695033283 3415 6848158 SGTC_2303 7774051 200 µM -0.527574390587527 0.309895319846899 no 2306 0.298897385795705 3446 2953184 SGTC_2313 7726885 200 µM -0.528288159920367 0.309626194253758 no 2307 0.298649674092548 3391 726423 SGTC_829 1635-0120 117 µM -0.528514623541757 0.309540827821008 no 2308 0.298571100020731 3419 285054 SGTC_2541 muurolladie-3-one 83.07 µM -0.528943651195688 0.309379132181694 no 2309 0.298422269890628 3469 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1902 st060212 70.5 µM -0.529407500438307 0.309204354198651 no 2310 0.298261398109594 3455 688944 SGTC_3115 9123671 49.47 µM -0.531394911947575 0.308455988412784 no 2311 0.297572573314043 3466 3286988 SGTC_1137 ixabepilone 100 µM -0.533072417894721 0.307824937107047 no 2312 0.296991725688644 3429 154225 A novel microtubule stabilizer. SGTC_2385 9074692 200 µM -0.533168732355622 0.307788722349443 no 2313 0.29695839191304 3347 17046906 SGTC_3227 9130768 49.47 µM -0.534004449761511 0.30747456673144 no 2314 0.296669227726703 3399 17720899 SGTC_1454 4239-0054 42.6 µM -0.535080442834654 0.307070296674242 no 2315 0.296297116456873 3516 1340767 SGTC_3154 9100113 49.47 µM -0.535742009531895 0.306821850440651 no 2316 0.296068432792801 3327 25237525 SGTC_1560 lithocholic acid 53.1 µM -0.53883132676805 0.305662857091518 no 2317 0.29500162287574 3388 9903 A bile acid which acts as a detergent. SGTC_2301 7769476 200 µM -0.539326576505361 0.305477238909535 no 2318 0.29483076696797 3375 977820 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.541141426659665 0.30479746580777 no 2319 0.294205053113534 3331 688667 SGTC_660 4031-1742 102 µM -0.541337143169777 0.304724198106638 no 2320 0.294137611737377 3363 6738706 SGTC_558 k064-0027 21.3 µM -0.541622155345769 0.304617516020676 no 2321 0.294039413009462 3393 5088526 SGTC_1254 0550-0035 264 µM -0.542890878319577 0.30414282568479 no 2322 0.293602468373654 3437 15121435 SGTC_1771 st048882 4.1505 µM -0.544562657030736 0.303517836630344 no 2323 0.293027171953701 3309 4580403 SGTC_957 1187-1561 14.1 µM -0.546131755892646 0.302931756502614 no 2324 0.292487686205768 3423 1538454 SGTC_906 1165-0455 526 µM -0.546860839784178 0.302659606060336 no 2325 0.292237170616193 3418 3252859 SGTC_2768 sulfasalazine 50.2 µM -0.548172011861112 0.302170451200295 no 2326 0.291786898983096 3499 5384001 An antioxidant and salicylic acid derivative. SGTC_2797 7859098 81.82 µM -0.548857711799293 0.301914780668987 no 2327 0.291551550505203 3367 972681 SGTC_2291 7917025 104.35 µM -0.549101110924345 0.301824050089655 no 2328 0.291468031446489 3325 2964612 SGTC_883 0850-0245 24.6 µM -0.549256171617522 0.301766255342196 no 2329 0.291414830324549 3482 6823229 YPR165W RHO1 SGTC_1045 1348-1485 165 µM -0.549501446365416 0.301674845866403 no 2330 0.291330686129964 3420 6810614 SGTC_258 haloperidol 50.781 µM -0.550274292779365 0.301386901408394 no 2331 0.291065626861534 3391 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_554 4483-2211 187 µM -0.552710440343263 0.30048006070073 no 2332 0.290230851564871 3414 747107 SGTC_1727 st034309 9.9045 µM -0.553362283102994 0.300237625466262 no 2333 0.29000768013664 3512 870305 SGTC_1563 conessine 56.1 µM -0.553840898339958 0.300059673830975 no 2334 0.289843867861069 3480 441082 An anti-amoebic, histamine inhibitor. SGTC_1082 camptothecin 424.86 nM -0.556420269948017 0.299101472610156 no 2335 0.288961792604067 3266 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1159 4092-0538 61.2 µM -0.556474410762484 0.299081374930857 no 2336 0.28894329145257 3459 717301 SGTC_2880 9042983 58.44 µM -0.557662591971354 0.298640463160043 no 2337 0.288537403237388 3473 6464714 SGTC_2652 actinonin 100 µM -0.558261549412083 0.298418313391398 no 2338 0.288332898494997 3418 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_573 3702-0553 84.7 µM -0.55850335586775 0.298328650122091 no 2339 0.288250356795045 3458 1222756 SGTC_483 fpl-64176 144 µM -0.559256372616758 0.298049505636775 no 2340 0.287993382626123 3468 3423 SGTC_2750 bromebric acid 70.15 µM -0.560406033080736 0.297623554444989 no 2341 0.287601258722628 3469 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_811 0416-0114 265 µM -0.560428307562902 0.297615304454978 no 2342 0.287593663879432 3463 6612453 SGTC_1907 st060210 83.7 µM -0.560523593464928 0.29758001378075 no 2343 0.287561175687826 3509 688793 SGTC_1652 st011932 78 µM -0.560675553210951 0.297523736984778 no 2344 0.287509367863724 3438 1551076 SGTC_1164 k060-0068 93.7 µM -0.560677882958259 0.297522874223618 no 2345 0.287508573614445 3475 5963676 SGTC_1992 st073643 23.3 µM -0.562028765293494 0.29702280265378 no 2346 0.287048210352801 3438 3161292 SGTC_3123 9126162 49.47 µM -0.564081855473386 0.296263523815305 no 2347 0.286349212935392 3445 25239884 SGTC_2507 purpurin 79.67 µM -0.564999657979045 0.295924388002878 no 2348 0.286036998407194 3340 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3313 9133968 57.047 µM -0.565554341346242 0.29571951425333 no 2349 0.285848386810561 3444 1494643 SGTC_3175 9106517 49.47 µM -0.568524231541155 0.294623687958899 no 2350 0.284839528382886 3440 41468073 SGTC_2867 9039098 71.43 µM -0.568711378813156 0.294554697382049 no 2351 0.284776012231929 3449 6463460 SGTC_2146 5545642 200 µM -0.569778813153594 0.294161337517812 no 2352 0.284413863611777 3483 825326 SGTC_2001 4023502 57.655 µM -0.569969212849512 0.294091198908051 no 2353 0.284349289809198 3438 108941 YCR052W RSC6 SGTC_1344 1488-0097 29.1 µM -0.570284236506186 0.293975168843969 no 2354 0.284242465345678 3477 747966 SGTC_2718 lomofungin 53.02 µM -0.570324106777575 0.293960485264995 no 2355 0.284228946711937 3493 5351222 A RNA synthesis inhibitor. SGTC_2460 5552655 174.22 µM -0.571305156600686 0.293599287298255 no 2356 0.283896403432866 3470 5401989 SGTC_1553 gossypol 38.6 µM -0.571709731696408 0.293450392748665 no 2357 0.283759320176377 3421 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1987 st072290 61.9 µM -0.571800150803215 0.293417120860915 no 2358 0.283728687563746 3407 54697379 SGTC_1850 st056238 17 µM -0.572357860703948 0.293211936718674 no 2359 0.283539778982733 3477 5393177 SGTC_1189 1431-2119 7.28 µM -0.573219555648757 0.292895045880756 no 2360 0.28324802255295 3509 3107275 SGTC_248 streptozotocin 5.23457 mM -0.573725516084725 0.292709051549256 no 2361 0.283076779388387 3478 5300 DNA alkylating agent. SGTC_1180 1193-0155 285 µM -0.577067923331029 0.291481741382437 no 2362 0.281946786044084 3487 2921347 SGTC_2033 5192550 145 µM -0.577339426404298 0.291382152716949 no 2363 0.281855092416715 3406 182073 SGTC_1786 berberine 21.6 µM -0.578595299456048 0.290921698985868 no 2364 0.281431138587816 3480 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_582 0987-0078 156 µM -0.578944261687389 0.290793815749207 no 2365 0.28131339162599 3548 1625765 SGTC_1622 st003707 19.4 µM -0.58016979038082 0.290344907957188 no 2366 0.280900061806621 3489 10140899 SGTC_2939 9044578 71.43 µM -0.58220046570808 0.2896017923434 no 2367 0.280215829857718 3457 2653634 SGTC_61 0978-8327 98.565 µM -0.584707336748641 0.288685648736626 no 2368 0.279372259994671 3507 6150059 YHR072W ERG7 SGTC_2838 9002687 71.43 µM -0.586601887981685 0.287994186064156 no 2369 0.278735557198178 3443 6457060 SGTC_3016 9080866 49.47 µM -0.586770063391713 0.287932844147368 no 2370 0.278679072555455 3475 17066299 SGTC_1495 4469-0029 237 µM -0.587211671132337 0.287771797267121 no 2371 0.278530777434949 3491 793680 SGTC_1037 k284-1091 78.7 µM -0.589031996644197 0.287108404945613 no 2372 0.277919904883395 3505 3334711 SGTC_2053 5265679 138 µM -0.589073103438717 0.287093432510122 no 2373 0.277906117644619 3455 764595 SGTC_2381 9035592 200 µM -0.590023538410686 0.286747356229527 no 2374 0.277587434422298 3459 4749657 SGTC_2689 tacrolimus 100 µM -0.590515446016488 0.286568318514937 no 2375 0.277422566723091 3469 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2200 6600604 21.907 µM -0.590729447601103 0.286490445739094 no 2376 0.277350856921007 3460 2904777 SGTC_1104 tacrolimus 29.8 µM -0.592574822879973 0.285819351325304 no 2377 0.276732866356855 3532 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_767 0929-0023 86 µM -0.59259599157265 0.285811657397338 no 2378 0.27672578117129 3554 1204563 SGTC_1478 0453-0656 35.7 µM -0.593034181353268 0.285652415998213 no 2379 0.276579138517035 3534 5258496 SGTC_2826 7992541 19.48 µM -0.593394913549449 0.285521354946609 no 2380 0.276458446069031 3559 2985066 SGTC_1715 st032160 10.2275 µM -0.59386071497084 0.285352162550806 no 2381 0.276302638162678 3460 5289825 SGTC_2266 7929956 200 µM -0.593904425643224 0.28533628803584 no 2382 0.276288019404589 3525 2967153 SGTC_457 grayanotoxin iii 135 µM -0.595049257267362 0.284920666513302 no 2383 0.275905272890869 3492 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1872 amphotericin b 148 nM -0.59574425941764 0.28466849275361 no 2384 0.27567304301082 3486 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3268 9137683 49.47 µM -0.596015085253703 0.284570255484594 no 2385 0.275582574565826 3500 1953228 SGTC_629 3448-6466 76.7 µM -0.596823890567503 0.284276972109586 no 2386 0.275312482851471 3519 573744 SGTC_1830 st055982 50.3 µM -0.5974047755553 0.284066424811501 no 2387 0.275118583062088 3501 455313 An antimicrobial agent. SGTC_1449 4112-4002 201 µM -0.597459110249623 0.284046734499516 no 2388 0.275100449545624 3478 2059539 SGTC_1017 4239-0030 168 µM -0.598496575976975 0.283670893328785 no 2389 0.274754321456879 3437 1149593 SGTC_2059 5238311 157 µM -0.599034509653803 0.28347611071166 no 2390 0.274574936042026 3466 703021 SGTC_395 anisomycin 6.25 µM -0.599048966440363 0.283470876879024 no 2391 0.274570115916709 3478 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.599724533173539 0.283226351149697 no 2392 0.27434491765891 3428 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_776 4476-4378 112 µM -0.60021935631773 0.283047310947185 no 2393 0.274180027638731 3511 2892008 SGTC_1421 4029-0249 71.4 µM -0.600457048836615 0.282961326777373 no 2394 0.274100838718933 3583 2894095 SGTC_628 1636-0253 16 µM -0.600999386523347 0.282765185590253 no 2395 0.273920197452916 3487 4456143 SGTC_3120 9124077 49.47 µM -0.601911383356548 0.282435501274591 no 2396 0.273616563257488 3531 18774327 YGL155W CDC43 SGTC_2982 9019404 25.97 µM -0.601914563043689 0.282434352150018 no 2397 0.273615504924876 3415 22333232 SGTC_1055 3448-0672 86 µM -0.603636835414438 0.281812261387946 no 2398 0.273042558644975 3513 748378 SGTC_2513 baicalein 25.65 µM -0.603806838539079 0.281750891495355 no 2399 0.272986036175161 3478 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3085 9117376 49.47 µM -0.604474397440728 0.281509969917264 no 2400 0.272764142985064 3536 16480349 SGTC_1467 k284-1082 293 µM -0.605364064174608 0.281189044328988 no 2401 0.272468561443172 3520 3334705 SGTC_1900 st060200 72.8 µM -0.605903605229908 0.280994504148332 no 2402 0.272289382646958 3516 688945 SGTC_3329 9141233 27.5565 µM -0.606139452235185 0.280909486161711 no 2403 0.272211077468982 3551 4909101 YNL103W MET4 SGTC_3112 9123419 49.47 µM -0.606232271292943 0.280876030213498 no 2404 0.272180263047833 3560 17015854 SGTC_350 k064-0020 19.8 µM -0.607377795966737 0.280463292907329 no 2405 0.271800110239434 3536 2790705 SGTC_1712 st032288 53.4 µM -0.607795850637351 0.280312739227169 no 2406 0.271661440822759 3547 2883011 SGTC_1002 4049-0206 172 µM -0.608337990242124 0.280117557253256 no 2407 0.271481664700622 3528 4662749 SGTC_1942 st076330 65.2 µM -0.608979902979141 0.279886539988267 no 2408 0.271268879976416 3585 24208414 SGTC_470 aa-861 153 µM -0.609222350526478 0.27979930985515 no 2409 0.271188533779363 3489 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2972 9093619 59.92 µM -0.609236852621768 0.279794092568533 no 2410 0.271183728216125 3461 25236256 SGTC_2264 7948757 110.76 µM -0.609854740013814 0.279571844708423 no 2411 0.270979018154347 3500 2971411 SGTC_2572 astragaloside iv 100 µM -0.610527747535826 0.279329868250008 no 2412 0.270756134192765 3540 45006101 An anti-inflammatory agent. SGTC_383 2324-0395 7.37 µM -0.611774552241326 0.27888185496638 no 2413 0.270343464340472 3543 3146421 SGTC_2561 acetosyringone 100 µM -0.611938219443202 0.278823070538884 no 2414 0.270289316805138 3474 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_170 4197-0004 226 µM -0.612605531837013 0.278583454060963 no 2415 0.2700685998084 3541 218692 SGTC_2294 7971431 200 µM -0.613931991944622 0.27810745087739 no 2416 0.269630134263589 3490 5741572 SGTC_1357 1503-1303 39.5 µM -0.615079850850176 0.277695859590625 no 2417 0.269250993958892 3540 292895 SGTC_2621 lithochol-11-enic acid 100 µM -0.61663581241514 0.277138409116857 no 2418 0.268737483717714 3554 6708711 SGTC_3104 9120930 49.47 µM -0.61696573340609 0.27702027954276 no 2419 0.268628663942903 3560 17014836 SGTC_453 enantio-paf c16 10 µM -0.61928944231147 0.276188964794682 no 2420 0.267862849173878 3559 13871343 A lipid and platelet activating factor SGTC_1780 st038448 24.544 µM -0.620090375009183 0.275902712410201 no 2421 0.267599144299014 3573 728868 YDL195W SEC31 SGTC_2023 5144124 124 µM -0.620524090401655 0.27574776390241 no 2422 0.267456399348958 3518 2830192 SGTC_2106 5357045 167.29 µM -0.620601791645714 0.275720008991096 no 2423 0.267430830275502 3524 668842 SGTC_2122 5258151 111.688 µM -0.620702400411015 0.275684073545423 no 2424 0.267397724877905 3504 2173356 SGTC_370 0180-0345 38.7 µM -0.621412507582785 0.275430502910478 no 2425 0.267164122325309 3479 3989527 SGTC_3186 9110464 49.47 µM -0.621431571864461 0.275423696869296 no 2426 0.267157852206483 3573 17018021 SGTC_3017 9080681 49.47 µM -0.621902496901736 0.275255600614309 no 2427 0.267002991594448 3531 16451914 SGTC_2528 xanthyletin 44.79 µM -0.622035964200531 0.275207968772192 no 2428 0.266959109994377 3553 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1479 0549-0158 134 µM -0.623726976008831 0.274604831719987 no 2429 0.266403451957816 3580 5440202 SGTC_1184 1269-1718 139 µM -0.624036215433547 0.274494605147456 no 2430 0.266301900752641 3562 5403821 SGTC_1845 st056753 3.01 µM -0.62466613295362 0.274270142308248 no 2431 0.266095102611763 3503 5375839 SGTC_2499 avocadenofuran 51.48 µM -0.624890838222054 0.274190093473789 no 2432 0.266021352905456 3452 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2534 helenine 20.12 µM -0.626948524426615 0.273457602009392 no 2433 0.265346488989465 3561 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3275 9138069 49.47 µM -0.627247796716238 0.273351148342357 no 2434 0.26524840842379 3571 17617007 SGTC_1742 st038235 28.8875 µM -0.629146887405037 0.272676104528709 no 2435 0.264626448355808 3535 564103 YBR002C RER2 SGTC_2911 7942208 15.64 µM -0.630043554317901 0.272357666367219 no 2436 0.264333044257481 3536 1243384 SGTC_844 0330-0132 15.3 µM -0.630174195348291 0.272311286535966 no 2437 0.264290310199839 3575 2828079 SGTC_2659 sanguinarine 24.21 µM -0.630921500945376 0.272046055537598 no 2438 0.264045926297514 3515 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1021 4476-0760 85.3 µM -0.632581450402489 0.271457372227974 no 2439 0.263503501817887 3482 746768 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.632691802108105 0.271418259683729 no 2440 0.263467462175679 3541 5379071 SGTC_3341 9147222 25.867 µM -0.632747849269913 0.271398395664109 no 2441 0.263449158758212 3552 1939759 SGTC_2789 5281112 71.43 µM -0.633269317045352 0.271213613788504 no 2442 0.263278893254155 3556 765948 SGTC_2354 9060492 162 µM -0.634247679142861 0.270867100923758 no 2443 0.262959597957211 3578 6471895 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.634798453157183 0.270672126960938 no 2444 0.26277993614077 3576 16486 A toxic proline analog. SGTC_1133 3473-0247 50 µM -0.635170930769595 0.270540309649056 no 2445 0.262658469991281 3506 711311 SGTC_966 1300-0360 30.2 µM -0.637730684529928 0.269635298485754 no 2446 0.261824503824131 3562 70588 SGTC_782 0083-0095 30.5 µM -0.639927114165994 0.268859952926353 no 2447 0.261109992679661 3599 3591729 An indicator and reagent. SGTC_2405 ticlatone 3.52 µM -0.64078366956199 0.26855789030666 no 2448 0.26083162218872 3476 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1361 1608-0041 5.61 µM -0.641143210566288 0.268431149706891 no 2449 0.260714821072413 3575 X1361 SGTC_1218 1348-1416 30.7 µM -0.642993548390954 0.26777936933176 no 2450 0.26011414308859 3582 6787668 SGTC_2372 9071633 200 µM -0.643027239200762 0.267767509159961 no 2451 0.260103212606834 3611 21321366 SGTC_2351 9026858 72.31 µM -0.644086038168643 0.267394915196902 no 2452 0.259759821736715 3536 1409300 SGTC_2656 pseudo-anisatin 100 µM -0.645365147516982 0.266945142545205 no 2453 0.259345291808545 3594 6708809 A neurotoxin. SGTC_1452 4194-0072 190 µM -0.64616502840258 0.266664075116362 no 2454 0.259086242609744 3632 1343545 SGTC_1229 0139-0193 12.2 µM -0.64634696702012 0.266600165214567 no 2455 0.259027338702661 3631 3090752 SGTC_2425 5628681 7.85 µM -0.648340008983203 0.265900573316228 no 2456 0.258382531120447 3595 5714958 SGTC_96 0929-0093 37.281 µM -0.648424964916763 0.265870773011421 no 2457 0.258355063874584 3566 6991579 SGTC_1165 k072-0275 30.3 µM -0.649041095910881 0.265654701138778 no 2458 0.258155906810738 3628 6153523 YGL055W OLE1 SGTC_2357 9067248 200 µM -0.650501022578488 0.265143073054486 no 2459 0.257684320714302 3574 9150235 SGTC_2822 7994718 71.43 µM -0.650752479476535 0.265055001085527 no 2460 0.257603140181385 3561 1018011 SGTC_804 1595-0054 20.9 µM -0.651373531044721 0.264837543471952 no 2461 0.257402696351326 3580 761523 Stimulates phospholipase C. SGTC_3306 9127676 59.7925 µM -0.651374678625326 0.264837141737203 no 2462 0.257402326045752 3571 41905287 SGTC_2251 lansoprazole 556 µM -0.651876556469648 0.264661478529995 no 2463 0.257240404774026 3506 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1749 st037932 54.2 µM -0.652142285602585 0.264568494177598 no 2464 0.257154693804608 3584 594497 SGTC_2440 5628896 157.78 µM -0.65764328096549 0.262647317921542 no 2465 0.255383688208187 3621 5522048 SGTC_2342 7990637 118.86 µM -0.657958502857108 0.262537445965576 no 2466 0.25528239825106 3636 2033102 YER133W GLC7 SGTC_1581 himbacine 57.9 µM -0.65832155888052 0.262410930373172 no 2467 0.25516576382607 3614 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1570 verbenone 133 µM -0.659036565984102 0.262161860283896 no 2468 0.254936144030398 3632 29025 A natural terpanoid with antifungal properties. SGTC_896 0964-0007 44.5 µM -0.661833868919852 0.261188595481271 no 2469 0.254038848799393 3597 6756758 SGTC_1663 st014140 55.4 µM -0.662289722113603 0.261030166739912 no 2470 0.253892781223159 3681 4207120 SGTC_954 1189-0853 2.85 µM -0.663048267648215 0.260766648842724 no 2471 0.253649820648884 3603 2828194 SGTC_1139 k015-0024 46.9 µM -0.664125329093494 0.260392714162454 no 2472 0.253305049986926 3608 2766652 SGTC_279 1273-0055 2.93 µM -0.664348628357249 0.260315223604467 no 2473 0.253233602056014 3656 2847562 SGTC_3158 9100007 49.47 µM -0.664673907428064 0.260202364706795 no 2474 0.25312954312895 3617 19297233 SGTC_3130 9127414 49.47 µM -0.665376672353504 0.25995861935784 no 2475 0.252904800790086 3635 1494646 SGTC_1160 4092-0570 10.5 µM -0.665609392976742 0.259877929041937 no 2476 0.252830400512747 3620 4994975 SGTC_1641 st009299 47.1 µM -0.665926702751063 0.259767930281025 no 2477 0.252728975836153 3581 4046054 SGTC_1637 st007924 17.4 µM -0.66626383978884 0.259651084521873 no 2478 0.25262123706657 3624 683336 SGTC_2098 5376439 882.5 nM -0.666468396383413 0.25958020203632 no 2479 0.252555878779183 3666 2844116 SGTC_585 0kpi-0023 191 µM -0.668834014166965 0.258761200011334 no 2480 0.251800683202488 3583 64601 SGTC_2793 7325131 81.82 µM -0.669124738797705 0.258660640411192 no 2481 0.251707955126616 3603 4176441 SGTC_422 cantharidin 155 µM -0.669742711232163 0.25844695533095 no 2482 0.251510909648801 3608 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2195 6536160 144.242 µM -0.67176709531088 0.25774759637158 no 2483 0.250865989778266 3528 3834386 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.674378503170006 0.256846892841983 no 2484 0.250035353024935 3574 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.674939216316023 0.25665371050202 no 2485 0.24985719184965 3639 7104 SGTC_2873 9040596 71.43 µM -0.675916858698458 0.256317064703488 no 2486 0.249546716698632 3630 6463863 SGTC_3008 9078912 71.4286 µM -0.676079212133579 0.256261181480187 no 2487 0.249495177098266 3625 16648731 SGTC_200 k038-0079 37.545 µM -0.676198003456458 0.256220296674323 no 2488 0.249457470008942 3604 3436683 SGTC_1100 amiodarone 5.07 µM -0.676986335781172 0.255949059904386 no 2489 0.249207312012606 3669 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2934 9036370 36.88 µM -0.677274837429053 0.255849834334661 no 2490 0.249115796421984 3637 6462800 SGTC_2691 st077356 60.2 µM -0.677569315827133 0.255748573865649 no 2491 0.249022403386199 3679 2839272 SGTC_2217 6934799 96.0675 µM -0.678030012099746 0.25559019906373 no 2492 0.248876332174964 3593 675606 SGTC_1866 st057638 64 µM -0.678794364862036 0.255327548494251 no 2493 0.248634082400864 3638 688802 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.680257384033345 0.254825212548921 no 2494 0.248170751625422 3668 229346 A bile salt which induces apoptosis. SGTC_838 0109-0203 71.4 µM -0.680630139850534 0.254697307467535 no 2495 0.248052775395036 3650 759422 SGTC_369 0957-0393 4.5 µM -0.682201051237834 0.254158644435421 no 2496 0.24755591502741 3630 6997992 SGTC_777 1315-0167 517 µM -0.682436664947356 0.25407790442398 no 2497 0.247481439126643 3616 4221767 SGTC_579 4491-1009 110 µM -0.682473467056885 0.254065294306899 no 2498 0.247469807309787 3775 1271041 SGTC_923 1900-2434 73.3 µM -0.68605149506445 0.252840864600448 no 2499 0.246340318189668 3638 5910570 SGTC_2598 perillyl alcohol 100 µM -0.686390561123339 0.252724994837534 no 2500 0.246233427495025 3662 10819 An apoptosis inducer. SGTC_801 0866-0028 10.1 µM -0.68677240706481 0.252594539298621 no 2501 0.246113080207095 3680 6849771 SGTC_3028 9087778 49.47 µM -0.690244257297728 0.251410030469974 no 2502 0.245020297919873 3628 17217395 SGTC_423 5-fluorouracil 457 µM -0.692013961450016 0.250807383074748 no 2503 0.244464280657213 3633 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3146 9095609 49.47 µM -0.692269834383872 0.250720312541345 no 2504 0.244383945107753 3695 17173999 SGTC_1817 st052116 64.4 µM -0.694333264977142 0.250018736962074 no 2505 0.243736617141909 3670 4361398 SGTC_661 1304-0007 33.6 µM -0.695358285010264 0.249670613237243 no 2506 0.243415398006665 3679 3117130 SGTC_2250 alverine citrate 130 µM -0.69599148172576 0.249455691710482 no 2507 0.243217082183317 3616 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_107 0358-0022 2.6945 µM -0.696200412128367 0.249384797506462 no 2508 0.243151664809569 3663 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.696398665639718 0.249317536085866 no 2509 0.243089599232911 3670 688798 SGTC_2428 5615643 7.78 µM -0.697692241749787 0.248878901703767 no 2510 0.242684840532135 3685 2253075 SGTC_210 3551-0445 56.827 µM -0.699965325187902 0.248109125656231 no 2511 0.241974479700941 3712 2865180 YOR207C RET1 SGTC_2512 diallyl trisulfide 49.23 µM -0.700708358969034 0.247857774170642 no 2512 0.24174251919633 3676 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_92 0063-0024 660.874 µM -0.700732919278954 0.247849468295807 no 2513 0.241734854012601 3734 3594437 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.700748894785312 0.247844065733792 no 2514 0.241729868185767 3717 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2306 7482397 179.52 µM -0.701795324144679 0.247490323487206 no 2515 0.24140340760926 3679 891448 SGTC_2937 9044753 11.33 µM -0.702921725573667 0.247109848628183 no 2516 0.241052265523138 3692 6465530 YGL099W LSG1 SGTC_2232 chlorophetanol 41.5365 µM -0.703161033784755 0.247029055631347 no 2517 0.240977699855489 3744 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3338 9144300 39.5675 µM -0.703654074916802 0.246862644265345 no 2518 0.240824113502256 3682 4901274 SGTC_35 0133-0054 64.071 µM -0.704217532484785 0.246672539421699 no 2519 0.24064865708417 3642 99677 SGTC_2110 5483698 200 µM -0.70433983428901 0.246631286396815 no 2520 0.240610582421863 3698 2848765 YHR062C RPP1 SGTC_873 0591-4978 488 µM -0.705657419495018 0.246187092592319 no 2521 0.2402006034586 3723 3305145 SGTC_2091 4-phenylthiadiazole 200 µM -0.708806571134001 0.245127168306904 no 2522 0.239222259712166 3698 270010 SGTC_879 0831-1030 162 µM -0.70922150980856 0.244987693729108 no 2523 0.239093513676826 3722 1549252 SGTC_847 0342-0274 5.54 µM -0.709588073418721 0.2448645151351 no 2524 0.238979808838618 3696 18097 SGTC_1194 1488-0194 225 µM -0.710185496178586 0.244663830992243 no 2525 0.238794556879611 3656 1391452 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.710585969881298 0.244529354880727 no 2526 0.238670419901035 3715 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1059 3448-6867 171 µM -0.71106663984257 0.244368002045991 no 2527 0.238521470698149 3653 3934407 SGTC_657 3534-0529 86.7 µM -0.712776024512653 0.243794655462304 no 2528 0.237992181930324 3713 1049549 SGTC_3239 9133757 49.47 µM -0.713110446666626 0.243682571542686 no 2529 0.237888707807042 3694 17036923 SGTC_1102 cgs 12066b 26.1 µM -0.713265250810196 0.243630697275042 no 2530 0.237840817949457 3696 6438352 A 5-HT1B full agonist. SGTC_1575 cyproterone acetate 48 µM -0.713856041466982 0.243432780434552 no 2531 0.23765810089646 3666 9880 An androgen receptor antagonist and liver toxin. SGTC_2273 7815444 169.05 µM -0.714230977779086 0.243307220591538 no 2532 0.237542182255469 3650 2824616 SGTC_2601 securinine 100 µM -0.714252288393138 0.243300085077964 no 2533 0.237535594608838 3669 442872 A GABA receptor antagonist. SGTC_386 1509-0011 3.07 µM -0.714950131084516 0.243066486272798 no 2534 0.237319929297978 3731 3107280 SGTC_1561 5-methoxyflavone 52.9 µM -0.715380032237082 0.242922639749351 no 2535 0.237187123722454 3660 94525 SGTC_359 0081-0058 15.9 µM -0.717142487533431 0.242333397411001 no 2536 0.236643090955642 3756 3494159 SGTC_1327 1436-0082 2.18 µM -0.71894127376961 0.241732808058408 no 2537 0.236088552179924 3711 15992205 SGTC_1701 st028638 40.4 µM -0.718966196838871 0.24172449227534 no 2538 0.236080873803814 3686 3490878 SGTC_709 3807-1509 243 µM -0.719858621772172 0.241426829843765 no 2539 0.235806023459999 3747 1886677 YPL242C IQG1 SGTC_637 1181-0519 7.26 µM -0.721659432888043 0.240826787958624 no 2540 0.23525194457049 3720 6252091 YGR060W ERG25 SGTC_207 4185-0010 4.486 µM -0.721678986598391 0.240820276992254 no 2541 0.235245932174727 3764 3761753 SGTC_201 4262-0159 12.803 µM -0.72198931490149 0.24071695714274 no 2542 0.235150523455229 3707 1341029 SGTC_2988 9073640 71.4286 µM -0.722860108807685 0.240427166289713 no 2543 0.234882916839357 3729 9102229 SGTC_1274 0865-0114 173 µM -0.724198377145733 0.239982175623104 no 2544 0.234471977372649 3725 870624 SGTC_3103 9120822 49.47 µM -0.724999834735319 0.23971589629899 no 2545 0.234226065906177 3766 17141819 SGTC_2480 5767542 37.17 µM -0.725782106791203 0.239456146813066 no 2546 0.233986178900673 3710 2867358 SGTC_2874 9043904 71.43 µM -0.7262922255547 0.23928684727875 no 2547 0.23382982218332 3704 4463428 SGTC_1375 2910-0797 186 µM -0.727224897806718 0.238977478749941 no 2548 0.233544098185772 3736 742508 SGTC_416 estradiol valerate 100 µM -0.728755640918153 0.238470203737209 no 2549 0.233075575231845 3739 13791 A steroid. SGTC_438 sphingosine 6.67 µM -0.730869109783244 0.237770788416711 no 2550 0.232429552806939 3671 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1193 1488-0126 41.5 µM -0.731699288863718 0.237496363362529 no 2551 0.232176065284551 3741 1384710 SGTC_2108 5365811 200 µM -0.734286734957344 0.236642170280179 no 2552 0.231387000392083 3788 780283 SGTC_1660 st012960 28.1 µM -0.734972597360636 0.236416030369055 no 2553 0.231178091525066 3717 24207266 SGTC_284 0988-0104 32.6 µM -0.735742923319971 0.23616218335555 no 2554 0.230943581183672 3743 4666532 SGTC_1311 1190-0148 100 µM -0.736062887366826 0.236056789127689 no 2555 0.230846213578681 3802 1961333 SGTC_2240 6690706 185.951 µM -0.737039395508742 0.235735293527667 no 2556 0.230549196172196 3664 805876 SGTC_550 4123-0385 25.7 µM -0.738459741582355 0.235268104561645 no 2557 0.230117561290224 3762 5731123 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.738751856470392 0.235172083754036 no 2558 0.230028845368053 3760 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_592 k241-0073 46.5 µM -0.739795797875549 0.234829107703862 no 2559 0.2297119545817 3730 4230158 SGTC_971 1315-0384 26.7 µM -0.7399226350464 0.234787455520357 no 2560 0.229673469534519 3763 6769120 SGTC_1487 3970-0795 2.82 µM -0.740682149756192 0.234538123205838 no 2561 0.229443092481079 3803 3765103 SGTC_1085 doxorubicin 7.67 µM -0.741000021722858 0.234433816180659 no 2562 0.229346713572318 3742 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1168 k815-0004 80.5 µM -0.741013933634997 0.234429251689469 no 2563 0.229342495993355 3722 642433 SGTC_486 niguldipine 82 µM -0.741372795372512 0.2343115263346 no 2564 0.229233717369346 3755 1236 A calcium channel blocker. SGTC_2305 7443522 69.23 µM -0.74200038939616 0.234105721456477 no 2565 0.229043549832402 3694 5415886 SGTC_589 1227-0070 34.1 µM -0.742425530009665 0.23396636336445 no 2566 0.228914778090536 3747 2841384 SGTC_1588 farnesol 29.9 µM -0.742701615138571 0.23387588922601 no 2567 0.22883117584402 3754 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_116 0155-0182 31.788 µM -0.742773401139481 0.233852367858701 no 2568 0.228809440896555 3709 771486 SGTC_1911 st060208 74.3 µM -0.744350344122891 0.233335998278807 no 2569 0.2283322757155 3788 688783 SGTC_806 3966-4455 5.86 µM -0.744622426221056 0.233246969105706 no 2570 0.228250003345462 3733 714982 SGTC_1 0258-0098 57.368 µM -0.745132801205848 0.233080017938019 no 2571 0.22809572076607 3681 6790032 YDR047W HEM12 SGTC_260 nsc-65238 3.989 µM -0.745444514172899 0.232978084685877 no 2572 0.228001521097772 3679 3246252 SGTC_162 k030-0015 37.8 µM -0.745633654302 0.232916246046739 no 2573 0.227944373613632 3801 1809920 YMR134W ERG29 SGTC_2980 9014342 25.29 µM -0.746052122879118 0.232779461758866 no 2574 0.227817964641798 3774 2996599 SGTC_227 fluconazole 33.516 µM -0.747516018087895 0.232301311581734 no 2575 0.22737606874948 3741 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.749039327448453 0.231804335730683 no 2576 0.226916751041665 3758 6312947 SGTC_693 4161-2696 114 µM -0.749513185574484 0.231649861571544 no 2577 0.226773977182636 3786 805759 SGTC_2259 7964009 200 µM -0.752253476551493 0.230757673523746 no 2578 0.225949319944051 3768 313134 SGTC_1314 1222-0010 41.1 µM -0.752988038798817 0.230518840264944 no 2579 0.225728550880354 3781 3526027 SGTC_1135 dihydrocapsaicin 536.708 nM -0.753710567963277 0.230284054246405 no 2580 0.225511517394106 3691 107982 A Capsaicinoid. SGTC_2464 5717415 7.67 µM -0.756060580454369 0.229521342724023 no 2581 0.224806437462025 3742 5285744 SGTC_1238 0333-0287 48.8 µM -0.75616095652608 0.229488796581519 no 2582 0.224776349246967 3765 7226 SGTC_1020 4335-0961 93.3 µM -0.756182057418405 0.229481955114079 no 2583 0.224770024442482 3722 669075 SGTC_2665 lovastatin 100 µM -0.756971956742239 0.229225931094853 no 2584 0.22453333176717 3783 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2147 5545932 89.7195 µM -0.757109409223351 0.229181396041085 no 2585 0.224492158695843 3788 797404 SGTC_3167 9103034 49.47 µM -0.758922748983228 0.228594322491939 no 2586 0.223949384810579 3785 5127859 SGTC_849 0386-0493 241 µM -0.760377540329815 0.228123941208796 no 2587 0.223514472240191 3735 726119 SGTC_1302 1159-0335 255 µM -0.761042760848556 0.227909035281899 no 2588 0.22331576350998 3786 649284 SGTC_81 0411-0046 9.971 µM -0.761666177930541 0.22770773779294 no 2589 0.223129633219629 3692 12925265 SGTC_2233 sulbentine 40.3845 µM -0.761952354639058 0.227615366643596 no 2590 0.223044220565193 3744 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_682 0kpi-0099 17 µM -0.762233686956598 0.227524579718592 no 2591 0.222960271925927 3794 1714895 YML126C ERG13 SGTC_1405 3909-7894 12 µM -0.763874787679806 0.22699539738657 no 2592 0.222470931701149 3775 7104060 SGTC_1761 st044296 37 µM -0.764458594028265 0.226807313184437 no 2593 0.222297001264845 3771 1826700 SGTC_2968 9090663 33.37 µM -0.767046178901772 0.225974733310683 no 2594 0.221527029972793 3777 25236811 SGTC_1362 1611-0397 101 µM -0.767284088285714 0.225898270551978 no 2595 0.221456313385812 3760 27816 SGTC_963 1269-2853 151 µM -0.767670392292416 0.225774145752491 no 2596 0.221341515226639 3793 3668223 SGTC_1060 3448-7350 82 µM -0.767878736420534 0.225707217930733 no 2597 0.221279615624641 3723 570178 SGTC_2429 5902844 64.44 µM -0.768008284883178 0.225665607844228 no 2598 0.221241131419972 3821 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3110 9122132 49.47 µM -0.768572520437711 0.225484429840962 no 2599 0.2210735619177 3922 918317 SGTC_2810 7959871 45.46 µM -0.768826793876334 0.225402808674605 no 2600 0.220998070264069 3793 2974535 SGTC_627 1391-0720 175 µM -0.770707459229528 0.224799639230428 no 2601 0.22044017480434 3785 997839 SGTC_698 k064-0052 127 µM -0.770823516788035 0.224762447104134 no 2602 0.220405773034569 3846 5088751 SGTC_252 miconazole 1.30953 nM -0.772224590925822 0.224313730424609 no 2603 0.219990709662003 3738 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_10 0279-0212 42.575 µM -0.772940163688539 0.22408475299655 no 2604 0.219778896837355 3792 39851 YBR002C RER2 SGTC_2942 9052777 62.25 µM -0.777623291318678 0.222589472273092 no 2605 0.218395563003367 3882 6469503 SGTC_821 1114-0266 29.2 µM -0.778854410033924 0.222197333441302 no 2606 0.218032741079103 3815 3123235 SGTC_877 0771-0151 33.1 µM -0.779803980042407 0.221895143664188 no 2607 0.217753131655294 3843 6166523 SGTC_1730 st033808 45.1 µM -0.781278001025377 0.221426518640813 no 2608 0.217319502962866 3781 1045166 SGTC_868 0527-0199 213 µM -0.782317708583423 0.221096312411126 no 2609 0.217013941097072 3771 2849450 SGTC_1488 4013-0813 75.9 µM -0.78342765502137 0.220744109814608 no 2610 0.216688010760182 3761 2910057 SGTC_2759 disulfiram 3.38 µM -0.78392155321023 0.220587491894766 no 2611 0.216543071041779 3762 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2790 5423970 71.43 µM -0.784837252201316 0.220297287045788 no 2612 0.216274497808077 3870 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1829 berberine 14.4 µM -0.786214076002117 0.219861354014366 no 2613 0.215871040497673 3838 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1775 st081588 35.1725 µM -0.78689358288906 0.219646389626533 no 2614 0.215672082175793 3839 1426443 YGL099W LSG1 SGTC_1778 st046819 58.9 µM -0.78810494062781 0.219263471869107 no 2615 0.215317662758091 3858 671715 SGTC_3247 9135149 49.47 µM -0.791145419094409 0.218304049592591 no 2616 0.214429568812675 3806 8934436 YOR116C RPO31 SGTC_480 am 92016 50 µM -0.792342440784946 0.217926994214813 no 2617 0.214080515717653 3747 2129 K+ channel blocker. SGTC_2193 5925765 200 µM -0.793027743293746 0.217711296770125 no 2618 0.213880829546201 3796 877370 SGTC_2026 5148700 152 µM -0.793868663458378 0.21744678738958 no 2619 0.213635947131208 3813 79838 SGTC_792 4534-1957 155 µM -0.794430789335579 0.217270075578457 no 2620 0.213472342885832 3794 1717904 SGTC_1996 st072960 66.8 µM -0.796498934378851 0.216620640800468 no 2621 0.212871047323274 3783 1719405 SGTC_1583 clindamycin 39.6 µM -0.797168367900968 0.216410667426655 no 2622 0.212676627201923 3796 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2202 7226349 200 µM -0.798831681808921 0.215889465462161 no 2623 0.212194008634339 3789 844334 SGTC_306 1672-3436 11.6 µM -0.799011490215 0.215833165821602 no 2624 0.212141874730147 3834 6797378 SGTC_222 nsc-310342 10.666 µM -0.800038749754271 0.21551168476411 no 2625 0.211844173280908 3775 432556 SGTC_2258 7960471 200 µM -0.802166157106085 0.21484679611306 no 2626 0.211228425064499 3850 2974708 SGTC_636 0kpi-0074 126 µM -0.80306087527159 0.214567521978343 no 2627 0.210969775012743 3860 616434 SGTC_1904 st060225 78 µM -0.804085615809768 0.214247922525408 no 2628 0.210673765616802 3786 66595 SGTC_860 0443-0016 25.1 µM -0.804369901582728 0.214159307638306 no 2629 0.210591689235194 3859 5337942 SGTC_2796 7949634 45.45 µM -0.804397318842344 0.214150762515755 no 2630 0.210583774567575 3811 2971588 SGTC_587 k089-0003 57 µM -0.805380300200224 0.213844528335089 no 2631 0.210300128105675 3746 9659696 SGTC_2285 7945142 200 µM -0.805644599634727 0.213762233039103 no 2632 0.210223900856897 3884 2970608 SGTC_926 2268-1401 59.4 µM -0.805732161662965 0.213734972792386 no 2633 0.210198650456328 3814 2931578 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.806233300271317 0.213578994786473 no 2634 0.210054170598157 3865 368090 SGTC_995 3931-2021 34.6 µM -0.80648250104933 0.213501456430857 no 2635 0.209982346945725 3848 730143 SGTC_1481 3346-2004 36 µM -0.806697550592977 0.213434557356637 no 2636 0.209920377827464 3872 2770522 SGTC_1071 trifluoperazine 6.31 µM -0.806795129402418 0.213404205907428 no 2637 0.209892262862613 3936 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2895 9054447 58.44 µM -0.807833671173625 0.213081328085602 no 2638 0.209593169418754 3868 2697450 SGTC_1418 3966-3099 2.4 µM -0.808876043936452 0.2127575459628 no 2639 0.209293224888197 3806 740335 SGTC_758 0868-0029 16 µM -0.809378937506126 0.212601439790401 no 2640 0.209148606803113 3914 762687 SGTC_2719 novobiocin 32.65 µM -0.81025586647556 0.212329387157863 no 2641 0.208896567424432 3824 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2655 perillic acid 100 µM -0.810959922851853 0.212111112686815 no 2642 0.208694343157642 3883 5702197 An apoptosis inducer. SGTC_2394 5221648 200 µM -0.811396323657846 0.211975883792361 no 2643 0.208569054843925 3937 788586 SGTC_3063 1327-0034 4 µM -0.811819294720151 0.211844864548808 no 2644 0.208447664466468 3734 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1603 st002045 67.8 µM -0.812836092893082 0.211530095719928 no 2645 0.208156019488383 3853 5887985 SGTC_610 4215-0184 155 µM -0.812983901135145 0.211484361730757 no 2646 0.208113644177303 3878 5605015 SGTC_1945 st075991 56.6 µM -0.813753310408056 0.211246389003642 no 2647 0.207893143612489 3865 1084980 SGTC_101 0490-5701 117.494 µM -0.814249202577006 0.211093096318642 no 2648 0.207751101874725 3694 4661669 SGTC_1390 3413-2614 145 µM -0.814466396001057 0.211025976929689 no 2649 0.207688907754502 3901 3421432 SGTC_2487 5918373 44.05 µM -0.815286649514416 0.210772606452589 no 2650 0.207454124436247 3861 2876279 SGTC_1392 3455-1037 33.9 µM -0.815460212013445 0.210719017112324 no 2651 0.207404465303801 3856 981132 SGTC_1655 st012546 55.1 µM -0.816168109468752 0.210500528743444 no 2652 0.207201996800854 3818 720985 YLR208W SEC13 SGTC_1853 st056710 91.2 µM -0.817083609257551 0.210218162401654 no 2653 0.206940324570473 3950 269167 SGTC_1178 0988-0033 191 µM -0.818344259651229 0.209829706014582 no 2654 0.206580320096966 3923 5392207 SGTC_2317 5986382 200 µM -0.819542339276441 0.209460921523107 no 2655 0.206238528008132 3887 877883 SGTC_2666 tannic acid 100 µM -0.819742259796788 0.209399420533531 no 2656 0.206181526677844 3868 16134267 A thiamine antagonist. SGTC_2857 9024691 58.44 µM -0.820973684939003 0.209020835027498 no 2657 0.20583062878605 3942 16478292 SGTC_680 0417-1641 114 µM -0.822244038081598 0.208630704368078 no 2658 0.205469009815435 3833 2835990 SGTC_2349 9023730 187.07 µM -0.823168916103759 0.208346940743522 no 2659 0.205205971333023 3856 4126287 SGTC_2833 9001315 45.46 µM -0.823272532298535 0.208315164245067 no 2660 0.205176515000179 3849 2989378 SGTC_521 r062-0005 13.8 µM -0.823535386679207 0.208234566199923 no 2661 0.205101801214766 3787 2832033 SGTC_2799 7812892 81.82 µM -0.823884790104303 0.208127458437373 no 2662 0.205002511745996 3878 20205235 SGTC_1922 5578187 25 µM -0.824861567868758 0.207828204956523 no 2663 0.204725093843149 3841 1350412 SGTC_1550 gossypolone 36.6 µM -0.825276292745884 0.207701223402946 no 2664 0.20460737401679 3868 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_965 1291-5240 308 µM -0.826469078874353 0.207336268580016 no 2665 0.204269025751614 3854 2834598 SGTC_2686 alizarin 95.37 µM -0.826678901467258 0.207272108741404 no 2666 0.204209541502092 3890 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2864 9034755 47.6 µM -0.827457900127415 0.207034008200216 no 2667 0.203988787335299 3835 4930451 SGTC_1211 1056-0033 32.3 µM -0.828470690826667 0.206724691335112 no 2668 0.203701993422426 3858 6741922 SGTC_146 3448-8650 53.125 µM -0.832473119128269 0.205504988001809 no 2669 0.202570972473422 3852 2891488 YIL048W NEO1 SGTC_1848 st056003 16.4 µM -0.83307312424506 0.205322510944262 no 2670 0.202401744948758 3903 146492 SGTC_3192 9110362 49.47 µM -0.834249062870063 0.20496515691562 no 2671 0.202070324443662 3896 16649480 SGTC_850 0388-0143 75.9 µM -0.834612219410632 0.204854872649918 no 2672 0.201968039938148 3828 67273 SGTC_1621 st003705 32.4 µM -0.834679670301649 0.204834392884787 no 2673 0.201949045535606 3918 24207032 SGTC_2727 riluzole 51.77 µM -0.835351407005339 0.204630503392725 no 2674 0.20175994053114 3886 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2180 6301957 200 µM -0.836678518493187 0.204228045768458 no 2675 0.201386648521328 3846 845462 SGTC_3102 9121669 49.47 µM -0.837782373052996 0.203893652030048 no 2676 0.201076470150801 3892 41905072 SGTC_1387 3342-1166 1.8 µM -0.839702972318908 0.203312617901567 no 2677 0.200537473520183 3875 3418228 SGTC_2344 7990960 76.95 µM -0.839818806500118 0.203277606496139 no 2678 0.2005049936023 3869 140813 SGTC_688 0527-0193 473 µM -0.839946573608286 0.203238992483088 no 2679 0.200469171354787 3907 4007154 SGTC_316 k060-0003 58.6 µM -0.841287030195638 0.202834141163508 no 2680 0.200093577377329 3878 6152314 SGTC_1852 st056254 31.4 µM -0.841452701440847 0.202784137789254 no 2681 0.200047185925472 3837 442583 SGTC_2216 7189485 200 µM -0.842495253585775 0.202469640724314 no 2682 0.199755397684876 3899 731273 SGTC_1391 3442-0225 151 µM -0.84399975704646 0.202016305506559 no 2683 0.199334770683611 3845 5227075 SGTC_2343 7990716 14.84 µM -0.845720810504608 0.20149846534626 no 2684 0.198854255494045 3891 6456862 SGTC_3138 9097216 49.47 µM -0.846006568208558 0.201412562036391 no 2685 0.198774540074405 3886 25237486 SGTC_1776 st049249 45.9 µM -0.851689027569765 0.199708886204165 no 2686 0.197193356089472 3955 1822314 SGTC_706 4262-0057 46.9 µM -0.852049193046833 0.199601196844705 no 2687 0.197093394644724 3887 883298 SGTC_2456 5770359 74.46 µM -0.854110945090844 0.198985406528715 no 2688 0.196521760017572 3942 3118787 SGTC_1485 3909-9022 254 µM -0.855590598039469 0.198544180118474 no 2689 0.196112136140155 3948 714516 SGTC_1127 asiatic acid 681.4 nM -0.855873125274111 0.198459998812246 no 2690 0.1960339808374 3894 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3294 9122953 26.2835 µM -0.857200346829519 0.198064830537412 no 2691 0.195667085421496 3910 16459826 SGTC_100 0086-0128 49.5915 µM -0.858505963877006 0.197676558778508 no 2692 0.195306569373637 3977 93297 SGTC_1011 4112-3381 17.4 µM -0.858700475446615 0.197618753228499 no 2693 0.195252894050332 4006 2877139 SGTC_2339 9000433 200 µM -0.863153162192846 0.196298285794107 no 2694 0.194026630923745 3943 2988954 SGTC_1990 st072050 59.8 µM -0.86402671874466 0.196039857088313 no 2695 0.193786606535664 3926 17233948 SGTC_1436 4092-1007 8.32 µM -0.864141179962679 0.196006010739023 no 2696 0.193755169804572 3896 2881121 SGTC_168 3970-0862 530.542 µM -0.864392227755159 0.195931787955194 no 2697 0.193686230510057 3907 3135186 SGTC_3229 9132204 49.47 µM -0.864914878464734 0.195777319939997 no 2698 0.193542755343898 3959 17682924 SGTC_2749 bexarotene 57.39 µM -0.865846599393006 0.195502135709479 no 2699 0.19328714533435 3966 82146 An retinoic acid receptor inhibitor. SGTC_2120 5538279 151.968 µM -0.866314169352718 0.195364127258866 no 2700 0.193158949015188 3909 2058197 SGTC_667 1498-1044 59 µM -0.866975796785045 0.195168941751954 no 2701 0.192977635564473 3934 6739982 SGTC_2497 7-hydroxyflavone 100 µM -0.869509372747175 0.194422612615189 no 2702 0.192284291878572 3958 5281894 SGTC_43 0570-0105 72.5 µM -0.86988393492538 0.19431242341331 no 2703 0.192181917840131 3938 1114046 YDL195W SEC31 SGTC_507 nimesulide 162 µM -0.870050908434552 0.194263315179749 no 2704 0.192136291965521 3975 4495 A COX2 inhibitor. SGTC_2949 9072542 2.23 µM -0.87009613111323 0.194250016132017 no 2705 0.192123935910803 3999 16457352 SGTC_887 0885-0007 9.62 µM -0.870227576073452 0.194211364055421 no 2706 0.192088024365087 4019 5719458 SGTC_1976 st070609 63.5 µM -0.870898922716242 0.194014024137868 no 2707 0.191904672533054 3832 682556 SGTC_1281 0884-0031 11.8 µM -0.87139918193646 0.193867054219915 no 2708 0.191768116158042 3940 1548255 SGTC_715 0868-0130 184 µM -0.871643079867466 0.193795424663643 no 2709 0.191701560620667 3959 2876258 SGTC_3198 9112019 49.47 µM -0.872471164305274 0.193552347753565 no 2710 0.191475696230633 3983 45595555 SGTC_393 acivicin 6.25 µM -0.873104402639845 0.193366591737333 no 2711 0.191303087204475 3784 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2427 5545055 42.75 µM -0.874361081558264 0.192998276085028 no 2712 0.190960822392984 3901 5372858 SGTC_2299 7976368 114.88 µM -0.87779770503701 0.191993237899974 no 2713 0.190026755064159 3988 2979718 SGTC_2774 tamoxifen 10.92 µM -0.877830272661805 0.191983728867339 no 2714 0.19001791670311 3955 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_172 1112-0046 2.638 µM -0.879215462645725 0.19157955064015 no 2715 0.189642231030834 3910 2802135 YIL048W NEO1 SGTC_2680 butyl paraben 22.24 µM -0.879353725963852 0.191539236051139 no 2716 0.189604756904248 3992 7184 An antifungal and steroid mimetic. SGTC_1512 0259-0544 12.2 µM -0.879735076867077 0.191428069325547 no 2717 0.189501421273099 3894 18476 SGTC_2611 pyromycin 23.93 µM -0.879865763797914 0.191389982176216 no 2718 0.189466016675093 3948 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_746 1095-0025 46.6 µM -0.880747110945684 0.191133245329365 no 2719 0.189227355866181 3967 6749286 SGTC_1826 st055655 41.6 µM -0.881682770777831 0.190860918382308 no 2720 0.188974190333064 3984 676168 SGTC_2624 nerol 100 µM -0.884574986174988 0.190020635666179 no 2721 0.188192951315887 3854 637566 A natural product oil. SGTC_752 1896-0090 130 µM -0.885123466837217 0.189861541052227 no 2722 0.188045022022739 3923 772567 SGTC_220 paclitaxel 373.376 µM -0.885366680657518 0.189791019644103 no 2723 0.187979448432876 3902 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1525 8-methoxypsoralen 92.5 µM -0.886727608421886 0.189396707223354 no 2724 0.18761278527345 4015 4114 Related to psoralen; DNA damaging agent. SGTC_134 0269-0018 6.916 µM -0.887032319535098 0.189308489983751 no 2725 0.187530750141931 3914 4378915 SGTC_1788 fluconazole 20 µM -0.889567565575041 0.188575489308714 no 2726 0.186849064248571 4012 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3258 9138477 49.47 µM -0.889992963967815 0.188452668061104 no 2727 0.186734832058727 3991 4970355 SGTC_1042 0350-0096 82 µM -0.890079460139158 0.188427700877876 no 2728 0.186711610539808 3948 3122515 SGTC_326 k292-0812 17.5 µM -0.890157670957096 0.188405127024419 no 2729 0.18669061491841 3928 3579357 SGTC_3193 9111931 49.47 µM -0.890423505587818 0.188328412104478 no 2730 0.186619262786232 3968 17087244 SGTC_228 caffeine 993.056 µM -0.890687404001931 0.188252275003434 no 2731 0.186548447053394 3940 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_31 0508-1974 57.237 µM -0.892714225183451 0.18766815184956 no 2732 0.186005115252536 3911 6810525 SGTC_3346 9158254 43.5805 µM -0.893436541035227 0.187460253724965 no 2733 0.185811720750726 3972 17639500 SGTC_785 1270-0111 65.3 µM -0.893908747551282 0.18732441945203 no 2734 0.185685358537471 3907 6741994 SGTC_2254 7938975 95.19 µM -0.894179931037134 0.187246438700168 no 2735 0.185612814086762 4037 2969277 SGTC_225 nsc-122657 1.016 µM -0.89560168424823 0.186837931958192 no 2736 0.18523276792793 3963 275685 SGTC_1185 1319-0113 81.3 µM -0.895720847020846 0.18680371845827 no 2737 0.185200936716152 4031 4672763 SGTC_1747 st037496 66.6 µM -0.896208007068602 0.186663887506576 no 2738 0.185070840012674 3966 723305 SGTC_1325 1431-0015 227 µM -0.898176562011068 0.186099507775641 no 2739 0.184545713369599 3947 1103340 SGTC_476 mead acid 10 µM -0.898704790358509 0.185948246220171 no 2740 0.184404962378764 3969 5312531 An omega 9 fatty acid. SGTC_681 1642-0006 26.6 µM -0.899587451330651 0.185695660801279 no 2741 0.184169918840985 3983 4446530 SGTC_1617 st002906 78 µM -0.900813309309434 0.185345218187401 no 2742 0.183843794944015 3964 5150859 SGTC_1235 benzylparaben 21.5 µM -0.902450569365377 0.184877806757982 no 2743 0.183408784171608 3984 7180 SGTC_3145 9085516 49.47 µM -0.902633194361635 0.184825715708418 no 2744 0.183360301551189 4035 25236195 SGTC_2817 7995342 71.43 µM -0.903138198105589 0.18468171843879 no 2745 0.183226276595698 3982 18879975 SGTC_981 1488-1094 54.9 µM -0.903811717580259 0.184489779007706 no 2746 0.183047623685433 3938 3449522 SGTC_2224 6650123 117.647 µM -0.904688397977913 0.184240128758401 no 2747 0.18281524463498 3937 2908370 SGTC_2051 5263410 176 µM -0.906094950334439 0.183840027577568 no 2748 0.182442798932498 4002 227584 SGTC_1401 3807-4679 7.6 µM -0.906453688788238 0.183738069225549 no 2749 0.182347883294433 3913 3291456 SGTC_1437 4092-1038 11.6 µM -0.906708371060722 0.183665706443412 no 2750 0.182280517750983 4001 3977136 SGTC_2267 7931562 200 µM -0.906912738427076 0.183607652460884 no 2751 0.182226472160144 3879 934880 SGTC_1372 2752-0194 270 µM -0.906938534231764 0.183600325542205 no 2752 0.182219651090617 3939 823334 SGTC_1353 1498-1206 8.11 µM -0.907930080057545 0.183318829659937 no 2753 0.181957582015578 4016 6756808 SGTC_301 4119-0100 24.5 µM -0.908223774195533 0.183235502760132 no 2754 0.181880002882127 4002 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1620 st003704 16.5 µM -0.909637233608295 0.182834806543929 no 2755 0.181506927840057 3897 2834414 SGTC_2963 9082507 9 µM -0.910262615950812 0.182657693950655 no 2756 0.18134201448058 4038 16459611 SGTC_1569 carminic acid 40.6 µM -0.910442381845739 0.182606802839018 no 2757 0.181294627569591 4067 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_871 0574-0004 149 µM -0.911670838796378 0.182259267911186 no 2758 0.180971009658984 3970 9551173 SGTC_2568 diosmetin 100 µM -0.913001973565393 0.181883152010477 no 2759 0.180620751786184 4041 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1885 st057546 99.9 µM -0.915186212682362 0.181267041737662 no 2760 0.18004694068782 4039 702008 SGTC_71 0417-1750 47.813 µM -0.915769351760893 0.181102776480696 no 2761 0.179893940768482 3992 6811472 SGTC_129 0088-0017 176.636 µM -0.916117511817842 0.181004747264454 no 2762 0.179802631930117 3825 182446 SGTC_1319 1306-0155 43.7 µM -0.918658373265707 0.180290340128953 no 2763 0.179137144625735 4028 3122360 SGTC_760 0568-0725 82.9 µM -0.918801791150494 0.180250068536997 no 2764 0.179099627720988 4021 3916171 SGTC_2049 5262831 67.185 µM -0.919405577558521 0.180080587866131 no 2765 0.178941736522377 4018 763417 SGTC_2097 5376186 200 µM -0.919852820132755 0.179955113007138 no 2766 0.178824838301063 3961 742755 SGTC_1419 3993-2473 62.6 µM -0.920719297570908 0.179712177175813 no 2767 0.178598499200917 4054 704026 SGTC_1723 st034307 2.5525 µM -0.922217224616099 0.179292686967551 no 2768 0.178207640140387 4056 867466 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.922795908451491 0.179130793230443 no 2769 0.17805678673234 3942 6708514 SGTC_3037 9091026 49.47 µM -0.923285537944972 0.178993885356069 no 2770 0.177929211232327 3963 25236398 YIL048W NEO1 SGTC_2371 9071574 200 µM -0.925115855629646 0.178482683927353 no 2771 0.177452823154594 4009 45596039 SGTC_2442 5158906 48.48 µM -0.928098372660703 0.17765164968345 no 2772 0.176678271844731 4031 1893835 SGTC_399 oxolinic acid 75 µM -0.928830507555995 0.177448024962091 no 2773 0.176488465723689 3968 4628 A DNA gyrase inhibitor. SGTC_827 3253-0474 693 µM -0.932425866636745 0.17645020674319 no 2774 0.175558241059011 4047 5402065 SGTC_321 4534-3890 65.3 µM -0.935733782254355 0.175535304048994 no 2775 0.174705136262212 4028 699746 SGTC_2984 9022109 38.96 µM -0.93722367431195 0.17512421378671 no 2776 0.174321757205904 4037 6459207 SGTC_2882 9058044 58.44 µM -0.937476446472205 0.17505452966112 no 2777 0.174256766944816 4042 18076804 SGTC_3299 9121982 43.1275 µM -0.938397890563576 0.174800655300536 no 2778 0.174019984799472 4087 17594604 YPL160W CDC60 SGTC_235 0330-0087 5 mM -0.939690570697857 0.174444892872405 no 2779 0.173688151613557 4034 46494818 YHR062C RPP1 SGTC_780 0109-0199 192 µM -0.940603818481797 0.174193832617743 no 2780 0.173453962181136 4118 610414 SGTC_2773 thioridazine 9.09 µM -0.941498033426264 0.173948227288417 no 2781 0.173224848291016 4040 5452 An antipsychotic. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.942468860026727 0.173681829205969 no 2782 0.172976323418918 4026 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2478 5763493 32.33 µM -0.947213994430156 0.172383485826176 no 2783 0.171764872846492 3962 1365576 YLR208W SEC13 SGTC_93 0109-0045 59.227 µM -0.94808567002872 0.172145656521706 no 2784 0.171542921389447 4124 88733 SGTC_1064 honokiol 6.76 µM -0.948335303493798 0.17207758473653 no 2785 0.171479391937709 4036 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2756 carbadox 75.1 µM -0.949089175492535 0.171872117996653 no 2786 0.17128762963499 4012 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2471 5466956 24.79 µM -0.949375910276336 0.171794009981558 no 2787 0.171214728956472 3991 724419 SGTC_3298 9116858 71.43 µM -0.950553035715528 0.171473592635419 no 2788 0.170915659486299 4099 2506942 SGTC_2028 5153890 36.43 µM -0.952462964185893 0.170954517090728 no 2789 0.170431120068506 4005 2830968 YPR165W RHO1 SGTC_2824 7998404 51.95 µM -0.95423210421851 0.170474602492133 no 2790 0.169983083639144 4001 837851 SGTC_13 0199-0087 65 µM -0.954961966820495 0.170276864303202 no 2791 0.169798465419588 4088 4589825 SGTC_1933 st074711 15.9 µM -0.955825701491399 0.17004304671245 no 2792 0.169580150544308 3999 17250958 SGTC_2388 9080168 200 µM -0.956998174383695 0.169725981473447 no 2793 0.169284088232548 4014 15943073 SGTC_2334 9017922 200 µM -0.957399349180093 0.169617581154782 no 2794 0.169182863414438 4118 3163164 SGTC_1288 0973-0013 65.5 µM -0.958178977855661 0.169407046925239 no 2795 0.168986257916348 4080 4315430 SGTC_1028 k015-0029 4.8 µM -0.958615290203735 0.169289296514213 no 2796 0.168876293446259 3989 4588309 SGTC_291 SEC14.278 35.5 µM -0.95887598391108 0.169218966511812 no 2797 0.168810612356866 4069 1068044 SGTC_1676 st018489 23.4 µM -0.961882290940986 0.168409280166957 no 2798 0.168054367583654 4072 3696235 SGTC_215 1287-0124 461.5 µM -0.962876561691822 0.168142043146703 no 2799 0.167804736555978 4061 5560863 SGTC_2529 gangaleoidin 93.61 µM -0.964551655670563 0.167692433985157 no 2800 0.167384711836173 4071 4565183 SGTC_2162 5663267 200 µM -0.964790930361242 0.167628273921902 no 2801 0.167324769781497 4027 6456493 SGTC_224 benfluorex 43.875 µM -0.964982118664467 0.167577019298613 no 2802 0.167276884063969 4062 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2544 sphondin 68.51 µM -0.96539995783987 0.167465038230401 no 2803 0.167172261294762 4052 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2816 7982706 58.44 µM -0.966023716229841 0.167297960458622 no 2804 0.167016156914548 4093 2981853 SGTC_2517 totarol 10 µM -0.967122465175715 0.167003914751658 no 2805 0.166741408126197 4070 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2813 7971799 71.43 µM -0.968053834495874 0.166754924118114 no 2806 0.166508742127967 4102 2234054 SGTC_1741 st038134 10.228 µM -0.96872386074687 0.166575948694475 no 2807 0.166341492098074 4137 1272587 SGTC_2618 avocadyne 43.43 µM -0.968917325697018 0.166524293988085 no 2808 0.166293220123502 3955 3015189 SGTC_143 4032-1194 15.74 µM -0.971282219685943 0.165893708453744 no 2809 0.165703880196085 4070 1806963 SGTC_204 PMA1.184 62.41 µM -0.976836085252721 0.16441887861158 no 2810 0.164325154080001 4072 2252213 YGL008C PMA1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.977013790035904 0.164371829835246 no 2811 0.164281162689171 4102 641818 SGTC_2732 terfenadine 20 µM -0.978121640282901 0.164078714378416 no 2812 0.16400708301447 4101 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_281 1672-3440 14.9 µM -0.979337816171717 0.163757328742438 no 2813 0.163706545609736 4110 6833000 SGTC_2316 5844804 197.44 µM -0.979360875279589 0.163751239111444 no 2814 0.163700850774169 4095 776813 SGTC_3304 9125678 46.087 µM -0.98195490007249 0.163067127011682 no 2815 0.163061033624212 4002 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1657 st012939 43.4 µM -0.982517402558493 0.162919025859189 no 2816 0.162922506923567 4088 24207257 SGTC_1896 st058441 89 µM -0.982835939242018 0.162835197204735 no 2817 0.16284409528314 4073 688759 SGTC_2731 amoxapine 43.43 µM -0.984463201827858 0.162407391539021 no 2818 0.162443907973639 4168 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3333 9141820 12.094 µM -0.985664013303577 0.162092168935831 no 2819 0.162149007138858 4057 1939433 SGTC_1188 1403-0014 4.57 µM -0.986877125698665 0.161774122113379 no 2820 0.161851439603029 4072 9614867 SGTC_2721 ifenprodil 61.44 µM -0.988007972492914 0.161478009700688 no 2821 0.161574371848327 4056 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1898 st060199 18.6 µM -0.988177910408329 0.161433541994651 no 2822 0.161532762252766 4046 688866 SGTC_2715 st079500 56.4 µM -0.992568414009888 0.160287446154745 no 2823 0.160460161952705 4039 28246688 SGTC_1232 0279-0259 161 µM -0.992686500986517 0.160256694382344 no 2824 0.160431377705221 4085 1560000 SGTC_1068 loratadine 26.9 µM -0.992813447215568 0.160223639817633 no 2825 0.160400437737102 4114 3957 A H1 histamine antagonist. SGTC_2992 9074591 71.4286 µM -0.994487796087754 0.159788085883132 no 2826 0.159992721953834 4036 17741321 SGTC_2135 5326629 150.42 µM -0.996720540762751 0.159208480912087 no 2827 0.159450088236564 4044 5020077 SGTC_2733 amorolfine 100 µM -0.997444651177516 0.159020802970601 no 2828 0.159274363547711 4183 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2172 5754775 163.918 µM -0.997887573752102 0.158906075940692 no 2829 0.159166939119137 4053 2263357 SGTC_1743 st037606 46.3785 µM -1.00039345354899 0.158258017869432 no 2830 0.158560068420365 4063 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_640 3381-0960 37.1 µM -1.00094857279902 0.158114690689698 no 2831 0.158425835945464 4144 1745025 SGTC_2270 7924575 90.91 µM -1.00173335584855 0.15791221163588 no 2832 0.158236196063994 4102 1262135 SGTC_2905 7799065 20.05 µM -1.00205681319614 0.157828807139 no 2833 0.158158077178043 4019 1296806 SGTC_1348 1493-0373 93.8 µM -1.00350157963743 0.157456622826955 no 2834 0.157809457575377 4091 3010129 SGTC_2569 tetrandrine 100 µM -1.00472697191786 0.157141403652942 no 2835 0.157514168430469 4110 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1888 azatryptophan 97.5 µM -1.00512876565615 0.157038136880293 no 2836 0.157417425203472 4141 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2806 7952793 58.44 µM -1.00570736907227 0.156889505916795 no 2837 0.15727817866523 4171 2972490 SGTC_1341 1486-1360 280 µM -1.00720861643239 0.156504299019328 no 2838 0.156917266637778 4077 3976547 SGTC_3156 9099931 49.47 µM -1.00889543884545 0.156072218793209 no 2839 0.156512391453514 4131 18111053 SGTC_8 0354-0001 70 µM -1.00897197085515 0.156052633748946 no 2840 0.15649403838215 4090 4993152 SGTC_3030 9087619 49.47 µM -1.00909698310349 0.156020645776775 no 2841 0.15646406235707 4133 25236973 SGTC_2088 5278280 127.392 µM -1.01126235209511 0.155467259703013 no 2842 0.155945439964417 4163 791502 SGTC_2855 9016525 58.44 µM -1.01139358434841 0.15543376339448 no 2843 0.155914045298081 4061 43811474 SGTC_345 1362-0200 395 µM -1.0132672007441 0.15495605249214 no 2844 0.155466274807967 4095 1419823 SGTC_387 norethindrone acetate 66.7 µM -1.01341612774191 0.154918122622738 no 2845 0.155430719585836 4112 541197 SGTC_2883 9059145 45.46 µM -1.01444759798057 0.15465558820275 no 2846 0.155184610952744 4101 16476510 SGTC_1706 st031321 9.9705 µM -1.01556022724481 0.154372726626329 no 2847 0.15491942635018 4117 6103185 SGTC_3019 9081971 49.47 µM -1.01624018720436 0.154200030229451 no 2848 0.154757511793966 4145 16451803 SGTC_3067 9117431 49.47 µM -1.01703448404775 0.153998456399561 no 2849 0.154568512556375 4145 17150885 SGTC_2111 5486399 200 µM -1.01920373139144 0.153448841161236 no 2850 0.154053127782544 4082 689674 SGTC_796 1234-0020 70.7 µM -1.01924053616597 0.153439527276593 no 2851 0.154044393269736 4043 46495034 SGTC_805 3852-0218 479 µM -1.02013026936015 0.153214483684741 no 2852 0.15383334139739 4068 6615355 SGTC_2785 7756463 72.73 µM -1.02083173703477 0.153037213077628 no 2853 0.153667082607973 4067 2201551 SGTC_1396 3511-0007 98.6 µM -1.02134877197284 0.152906638254069 no 2854 0.153544613445417 4120 X1396 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.02397632373988 0.152244203897767 no 2855 0.152923229014898 4174 1273210 SGTC_912 3474-0017 2.18 µM -1.02422131355478 0.152182536555497 no 2856 0.152865376963736 4168 3360550 SGTC_3228 9131799 49.47 µM -1.02478865833805 0.152039791671853 no 2857 0.15273145953097 4112 17015818 SGTC_223 busulfan 5 mM -1.02588284321925 0.151764744162996 no 2858 0.152473405307132 4118 2478 A DNA alkylator. SGTC_1905 st060207 84.5 µM -1.02656497859174 0.151593441811174 no 2859 0.152312675965622 4085 1948547 SGTC_1839 st053978 48 µM -1.02816128102544 0.151193070283357 no 2860 0.151936984127722 4116 3788398 SGTC_2865 9030313 51.95 µM -1.02915929061545 0.150943115375831 no 2861 0.151702414289087 4076 42562754 SGTC_2000 st075254 36.4 µM -1.0331310006971 0.149951113537089 no 2862 0.150771298737953 4037 17234175 SGTC_2957 9076800 11.52 µM -1.03363693292046 0.149825061280734 no 2863 0.150652963337357 4092 16459615 SGTC_677 0929-0063 136 µM -1.03466281182626 0.14956968209682 no 2864 0.150413204521578 4099 1539583 SGTC_2818 7996756 12.99 µM -1.03593069635511 0.149254460349743 no 2865 0.150117237849879 4143 2241621 SGTC_3051 9093778 49.47 µM -1.03727503293236 0.148920715942388 no 2866 0.14980384903423 4167 17217378 SGTC_2725 haloperidol 53.21 µM -1.03909096637308 0.148470685375292 no 2867 0.149381215939623 4067 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3023 9089636 49.47 µM -1.04136361343613 0.1479087531227 no 2868 0.148853411616276 4199 17249241 SGTC_174 3553-0389 74.3 µM -1.04605460402874 0.146753371624761 no 2869 0.147767911333536 4223 738071 SGTC_549 1661-1316 519 µM -1.04686366199244 0.146554716179308 no 2870 0.147581231753033 4173 2857282 SGTC_3074 9116018 49.47 µM -1.04842370397943 0.146172174471602 no 2871 0.147221718569606 4195 17027303 SGTC_3134 9127454 49.47 µM -1.04935231136176 0.145944787088508 no 2872 0.147007999056353 4180 24262820 SGTC_191 3914-0123 66.505 µM -1.05095744371444 0.145552300335295 no 2873 0.146639067796391 4133 3144412 SGTC_574 1315-0397 40 µM -1.05323547807876 0.144996495191549 no 2874 0.146116541015619 4118 6794277 SGTC_1644 st010134 20.9 µM -1.05389529154786 0.144835778099843 no 2875 0.145965429416439 4122 3818134 SGTC_445 e6 berbamine 66 µM -1.05398803678551 0.144813196872574 no 2876 0.145944197165315 4168 6610268 A calcium/calmodulin antagonist. SGTC_3332 9141069 11.198 µM -1.05454780118031 0.144676958086834 no 2877 0.145816093859206 4097 17332883 SGTC_1214 0358-0031 63.7 µM -1.05666892260232 0.144161490527087 no 2878 0.145331356516974 4266 4301366 SGTC_3053 9095903 49.47 µM -1.05835190187278 0.143753380795328 no 2879 0.144947519425405 4250 17174018 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.06076566821208 0.143169422730307 no 2880 0.144398204072407 4133 442882 SGTC_171 k064-0041 9.68 µM -1.0608762927182 0.143142698002785 no 2881 0.144373062254059 4167 53325 SGTC_2854 9024559 71.43 µM -1.06126065127235 0.143049870652849 no 2882 0.144285731370126 4204 3163529 SGTC_2775 cyproheptadine 69.59 µM -1.06126412280395 0.143049032420362 no 2883 0.144284942758711 4151 2913 A selective serotonin reuptake inhibitor. SGTC_2383 9036125 200 µM -1.06437078394922 0.142300231315911 no 2884 0.143580381774761 4081 79580 SGTC_3022 9087993 49.47 µM -1.06529791191391 0.142077279641898 no 2885 0.143370568708192 4215 17173644 SGTC_455 paf C-16 10 µM -1.0663693289328 0.141819924617169 no 2886 0.143128360386781 4142 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_753 1322-0200 289 µM -1.06678589263911 0.141719951042088 no 2887 0.143034265192578 4232 5403907 SGTC_2243 6634756 200 µM -1.06906534116088 0.141173738156561 no 2888 0.142520113804273 4228 885676 SGTC_2645 abamectin 100 µM -1.06960937335384 0.141043585704074 no 2889 0.142397587136782 4118 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3070 9117005 49.47 µM -1.07168126638241 0.140548658171192 no 2890 0.14193160897617 4245 8779016 SGTC_2170 morpholine 200 µM -1.0718557769864 0.140507025503407 no 2891 0.141892407943401 4204 121171 Reacts with secondary amines. SGTC_1925 st057770 10.1 µM -1.07589648452188 0.139545382385847 no 2892 0.140986777170916 4157 5989122 SGTC_3241 9133421 49.47 µM -1.07896427246668 0.138818279176136 no 2893 0.140301827432266 4216 17018221 SGTC_2314 7727897 200 µM -1.07935267170989 0.138726408152761 no 2894 0.140215270380734 4177 900724 SGTC_1781 st038725 66.3 µM -1.08056953025785 0.138438843527982 no 2895 0.139944321182378 4158 4270275 YIL048W NEO1 SGTC_2271 7849410 118.62 µM -1.08074606771482 0.138397158454581 no 2896 0.139905042422863 4116 972430 SGTC_379 3970-0972 5.9 µM -1.08274212923496 0.137926431724487 no 2897 0.139461449356106 4176 2898042 YBL034C STU1 SGTC_2571 chrysanthemic acid 100 µM -1.08361101901816 0.137721864969396 no 2898 0.139268651548199 4187 2743 An insecticide. SGTC_2367 9070478 135.38 µM -1.08535533716916 0.137311817351095 no 2899 0.138882152803095 4124 572802 SGTC_430 0958-0115 16.4 µM -1.08762991296463 0.136778372412821 no 2900 0.138379259893518 4134 6833180 SGTC_919 tnp00227 403.569 nM -1.08801865304526 0.13668734508071 no 2901 0.138293436503549 4143 1269246 A methoxyflavone. YNL221C POP1 SGTC_11 0438-0307 1.3 µM -1.08861011421703 0.136548928068071 no 2902 0.138162927344542 4166 4011476 SGTC_1572 epiandrosterone 68.9 µM -1.08873477099596 0.136519767434881 no 2903 0.138135431859374 4107 441302 A steroid. SGTC_1089 terbinafine 2.25 µM -1.09103290468584 0.135982934038072 no 2904 0.137629202041611 4190 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1003 4049-0218 100 µM -1.09186230379905 0.135789545626486 no 2905 0.137446814455907 4214 295161 SGTC_9 0092-0002 10.449 µM -1.09292760673927 0.13554142870791 no 2906 0.137212793048599 4171 759368 SGTC_1057 3448-5381 134 µM -1.09390149141318 0.135314875728812 no 2907 0.136999092297195 4174 5497911 SGTC_2079 5212404 121 µM -1.09608478524289 0.13480792379656 no 2908 0.136520836147796 4171 758462 SGTC_2336 9001819 198.65 µM -1.0967485387366 0.134654061572755 no 2909 0.136375665844562 4262 2989602 SGTC_615 k087-0205 167 µM -1.09701839184215 0.134591542402972 no 2910 0.136316676162008 4201 9642773 SGTC_825 1988-2224 89.6 µM -1.09712102057387 0.134567770759997 no 2911 0.136294246182688 4178 1180859 SGTC_2157 5649910 96.377 µM -1.09760030562971 0.134456793288394 no 2912 0.136189529673866 4182 2858091 SGTC_2987 9018338 71.43 µM -1.09897867328128 0.134137985351547 no 2913 0.135888684187495 4220 5055682 SGTC_2853 9015042 58.44 µM -1.09938275892169 0.134044621346984 no 2914 0.135800573910149 4109 6457456 SGTC_658 3253-0951 102 µM -1.09976606427339 0.133956099901846 no 2915 0.135717030910997 4193 1184878 SGTC_484 loperamide 105 µM -1.1008021832743 0.133717017218563 no 2916 0.135491380672847 4202 3955 An opioid-receptor agonist. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.10170206939598 0.133509608210723 no 2917 0.135295608504846 4220 5377381 SGTC_2929 9013348 24.6 µM -1.10223549177649 0.133386767594182 no 2918 0.135179652895279 4186 2995952 SGTC_1056 3448-1962 115 µM -1.10252818386017 0.133319397251082 no 2919 0.135116056311366 4195 715507 SGTC_2734 clemastine 41.6 µM -1.1070807509296 0.132274524425957 no 2920 0.134129508543704 4263 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2018 5133068 143 µM -1.10729242709986 0.132226079731747 no 2921 0.134083758717 4148 785362 SGTC_2805 7950783 58.44 µM -1.10748974359655 0.132180932441504 no 2922 0.134041122119489 4221 1178958 YDL195W SEC31 SGTC_2134 5324836 1.464 µM -1.11036638506076 0.131523945034051 no 2923 0.133420588642731 4152 699272 SGTC_482 fipronil 114 µM -1.11330148186677 0.130855933976895 no 2924 0.132789485114741 4301 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2155 5570423 76 µM -1.11389677020581 0.130720736312186 no 2925 0.132661737589734 4161 797402 SGTC_2622 2-methoxyxanthone 59.94 µM -1.11431930802375 0.130624831134303 no 2926 0.13257111331956 4200 71034 A hepatoprotective. SGTC_2850 9015429 58.44 µM -1.11622697685871 0.130192445244715 no 2927 0.132162494931893 4226 6457570 SGTC_553 k007-0256 45.7 µM -1.11643222311369 0.130145983886794 no 2928 0.132118583439068 4264 6287000 SGTC_45 0kpi-0036 14.9 µM -1.11810857024384 0.129766940671828 no 2929 0.131760313291476 4246 2795021 SGTC_1732 st034308 51.822 µM -1.12008049968834 0.129322041971539 no 2930 0.131339729816024 4076 830119 SGTC_1821 st053465 65.6 µM -1.12411975521891 0.128414024908637 no 2931 0.130481112799693 4213 675086 SGTC_1934 st074720 32.6 µM -1.12573321434372 0.128052562303963 no 2932 0.130139230209212 4166 17250992 SGTC_975 1335-0046 28.5 µM -1.12622981945383 0.127941450444749 no 2933 0.130034127353956 4234 16486740 SGTC_666 0272-0154 136 µM -1.12743197829336 0.127672753370602 no 2934 0.129779942493822 4227 6870312 SGTC_3057 9095946 49.47 µM -1.12782110534788 0.1275858628545 no 2935 0.129697739101676 4265 24540043 SGTC_2703 st077852 53.4 µM -1.13090959903143 0.126897672655234 no 2936 0.129046571346862 4256 6281836 SGTC_1395 3486-0190 4.35 µM -1.13961598473524 0.124971606616088 no 2937 0.127223161444178 4223 6748079 SGTC_2720 fluspirilene 36.88 µM -1.14062238721649 0.124750289536669 no 2938 0.127013548448722 4223 3396 An atypical antipsychotic. SGTC_1515 3460-0031 42.1 µM -1.14121399208723 0.124620318136638 no 2939 0.126890441524862 4182 2876596 SGTC_2496 diffractaic acid 79.83 µM -1.14365139792167 0.124085835782277 no 2940 0.126384118486599 4259 94870 An apoptosis inducer which activates caspases. SGTC_181 1447-1644 8.07 µM -1.14697168327131 0.123360336373822 no 2941 0.125696662124386 4220 534600 SGTC_429 1112-0049 25.5 µM -1.1470446609034 0.123344423833254 no 2942 0.12568158165365 4217 2836170 SGTC_889 0919-1524 82.7 µM -1.15114908409114 0.122451781422028 no 2943 0.124835453882463 4261 3905452 SGTC_1266 0828-0227 32.9 µM -1.15232529214487 0.122196813902678 no 2944 0.12459371376856 4231 3913820 SGTC_2589 lobaric acid 100 µM -1.15254527161133 0.122149170188089 no 2945 0.124548538845392 4225 73157 A novel microtubule depolymerizer. SGTC_3170 9103054 49.47 µM -1.15314694068007 0.122018925791875 no 2946 0.124425038744378 4216 16432970 SGTC_3243 9134147 49.47 µM -1.15470650423375 0.12168177838613 no 2947 0.124105317550205 4342 24282180 SGTC_526 4469-0568 170 µM -1.15630923090228 0.121335982566747 no 2948 0.123777346969207 4206 2901964 SGTC_1753 st043925 64 µM -1.15897005680197 0.120763423800294 no 2949 0.123234195278958 4284 670181 SGTC_2319 6033012 152.6 µM -1.15958705087659 0.120630930552395 no 2950 0.123108487812874 4195 847246 SGTC_1016 4226-1401 38 µM -1.16005580879405 0.120530337959701 no 2951 0.123013042345405 4218 2901613 SGTC_601 0986-0029 62.9 µM -1.16271317758274 0.119961199380069 no 2952 0.122472946651956 4197 24747981 SGTC_1772 st048439 82.2 µM -1.16307896818452 0.119883005218758 no 2953 0.122398732202041 4302 2927068 YDL195W SEC31 SGTC_1931 st074438 57.1 µM -1.16379409519508 0.119730238079363 no 2954 0.122253732837961 4251 2787313 SGTC_1299 1079-1439 3.74 µM -1.16607185584876 0.119244572566083 no 2955 0.121792697269459 4220 323161 SGTC_3005 9076496 71.4286 µM -1.16609907984387 0.119238776270261 no 2956 0.121787194329072 4222 21368410 SGTC_2181 6316240 54.2555 µM -1.16877838576991 0.118669294374105 no 2957 0.12124646543401 4274 12779990 SGTC_1926 methyl fluorone black 53.6 µM -1.17105336740065 0.118187261656229 no 2958 0.120788663228967 3927 72721 Reacts with homocysteine. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.17202359553379 0.117982107354912 no 2959 0.120593791506757 4314 279621 SGTC_642 0335-0876 158 µM -1.17244484072384 0.117893113725794 no 2960 0.120509252757376 4295 6812350 SGTC_1860 st056228 74.6 µM -1.17276937307392 0.117824584362922 no 2961 0.120444151557643 4244 688679 SGTC_1237 0330-0133 46.1 µM -1.17435579810794 0.117489995099329 no 2962 0.120126271131807 4199 X1237 YHR072W ERG7 SGTC_2683 piperine 63.03 µM -1.17502319625952 0.117349436911759 no 2963 0.119992717843283 4241 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1810 st050138 53 µM -1.17619878644922 0.117102140046773 no 2964 0.119757724666941 4269 3444541 SGTC_2081 5214970 32.255 µM -1.17802265843906 0.116719201976547 no 2965 0.119393786609621 4222 2063512 SGTC_1879 gemcitabine 100 µM -1.17967838148716 0.116372337855439 no 2966 0.119064077652706 4238 60750 A nucleoside analog which inhibits DNA replication. SGTC_219 mitoxanthrone 164.414 µM -1.18168236672307 0.11595349388189 no 2967 0.118665878782373 4204 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1243 0416-0003 5.65 µM -1.18356377090245 0.115561245134492 no 2968 0.118292894401252 4265 2141977 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.18411739814705 0.115446000649451 no 2969 0.118183296982387 4278 2374 Ca(2+)-ATPase inhibitor. SGTC_1223 0764-0573 147 µM -1.18578200473305 0.11509998383385 no 2970 0.11785419992787 4269 1609797 SGTC_600 1495-0418 41.6 µM -1.18639583784739 0.114972574460544 no 2971 0.117733007317767 4250 5377768 SGTC_783 0848-0141 92.7 µM -1.18815510599985 0.114607970336729 no 2972 0.117386153583642 4201 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_545 4218-0007 221 µM -1.18818946679992 0.114600857345118 no 2973 0.117379386290623 4263 2840508 SGTC_1147 3809-1045 12.3 µM -1.18987286388431 0.114252763821032 no 2974 0.117048182766019 4273 325925 SGTC_3276 9139060 49.47 µM -1.19220035617457 0.113772725192444 no 2975 0.116591346907453 4387 4870619 SGTC_1466 k213-0079 57.5 µM -1.19228494568573 0.11375530596019 no 2976 0.116574767681303 4219 3657981 SGTC_2835 9006588 71.43 µM -1.19426359228516 0.113348392103212 no 2977 0.116187437252564 4323 2345538 SGTC_1546 5-methoxyflavanone 78.7 µM -1.19431245101261 0.113338357329681 no 2978 0.116177884469349 4291 147795 SGTC_1259 0671-0132 43 µM -1.1947628499539 0.113245882689561 no 2979 0.116089849413469 4201 X1259 SGTC_3097 9117246 49.47 µM -1.19554961166926 0.113084476153242 no 2980 0.115936182448359 4293 16423892 SGTC_3325 9138760 55.175 µM -1.19604280565517 0.112983379667841 no 2981 0.115839927559807 4220 43844959 SGTC_2006 4011487 200 µM -1.19698298416313 0.112790837589118 no 2982 0.115656593548393 4290 45595294 SGTC_2897 9048598 12.99 µM -1.19834806145018 0.112511696357194 no 2983 0.115390771664564 4249 6467404 SGTC_3273 9137859 49.47 µM -1.19997983638549 0.112178666746908 no 2984 0.115073585761835 4376 2377234 SGTC_1956 st077085 54 µM -1.20240104241786 0.111685821087964 no 2985 0.11460409275923 4318 24208685 SGTC_1635 st007035 42.4 µM -1.20477283527235 0.111204537444963 no 2986 0.114145504742898 4263 3716403 SGTC_1241 0364-0022 50.8 µM -1.20732978977823 0.110687346193221 no 2987 0.113652581292211 4294 4563895 SGTC_2016 5121758 140 µM -1.20917059739292 0.110316077591268 no 2988 0.113298655614224 4228 2795203 SGTC_2214 7179297 48.276 µM -1.20998037917257 0.110153037557451 no 2989 0.11314321094365 4351 769744 SGTC_2092 5303694 80.6725 µM -1.21010122765704 0.110128720966909 no 2990 0.11312002607945 4285 1963699 SGTC_2875 9039966 71.43 µM -1.212342802319 0.109678379318198 no 2991 0.112690592942959 4306 6463691 SGTC_1416 3966-0321 25.3 µM -1.21270453783206 0.109605829221977 no 2992 0.112621402139072 4335 582530 YLR208W SEC13 SGTC_433 pimozide 108 µM -1.21436617008246 0.109273012993217 no 2993 0.112303963932272 4210 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1394 3474-0001 65.7 µM -1.21804105982463 0.108539531768871 no 2994 0.111604184961623 4278 5017666 YIL048W NEO1 SGTC_1594 piperine 70.1 µM -1.21889381158717 0.108369836182202 no 2995 0.111442249394269 4279 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3121 9125696 49.47 µM -1.2217189918133 0.107808996159559 no 2996 0.110906955885566 4414 1235365 SGTC_1308 1187-1617 41.4 µM -1.22233981296939 0.107686034668913 no 2997 0.110789574705132 4328 2882570 SGTC_2011 4012611 177 µM -1.2227971419832 0.107595519519122 no 2998 0.110703162605798 4277 2049887 SGTC_2087 5276107 200 µM -1.22353586711843 0.107449425905751 no 2999 0.110563682882301 4256 144405 SGTC_362 0310-0100 9.03 µM -1.22585886320837 0.106990951541196 no 3000 0.110125895742244 4359 790235 SGTC_50 0929-0078 56.389 µM -1.2279376653777 0.106581869990773 no 3001 0.10973518440907 4155 1377751 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.23066017968076 0.106047823448346 no 3002 0.109224993589049 4300 688803 SGTC_3165 9101544 49.47 µM -1.2307372693114 0.10603272979866 no 3003 0.10921057208296 4313 5002184 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.23402598743673 0.105390265040062 no 3004 0.108596610350097 4324 66535 A nucleotide analog. SGTC_463 ikarugamyin 104 µM -1.23642732889624 0.104922934956817 no 3005 0.10814988143968 4466 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_339 3091-4833 71.4 µM -1.23769625177321 0.104676593916371 no 3006 0.107914354745752 4165 3240077 SGTC_2735 sertaconazole 140 nM -1.23778580513037 0.104659224405475 no 3007 0.107897746577176 4454 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1867 st057372 64 µM -1.23972224978048 0.104284147668879 no 3008 0.10753907229088 4275 688837 SGTC_460 trequinsin 123 µM -1.24294487295414 0.103662107955022 no 3009 0.106944074226341 4398 5537 A vasodilator. SGTC_469 w7 172 µM -1.24615802914185 0.10304458026118 no 3010 0.10635319212057 4413 45115570 A P450 inhibitor. SGTC_3079 9117512 49.47 µM -1.24656156312428 0.102967215427094 no 3011 0.106279151356811 4392 7185044 SGTC_719 2810-4230 27.3 µM -1.2509536590547 0.10212789809272 no 3012 0.10547569251854 4340 721079 SGTC_64 000l-0018 272.079 µM -1.2522898235768 0.101873550917127 no 3013 0.105232137830446 4252 6811119 SGTC_1205 4161-2785 76 µM -1.25359655936176 0.101625251918942 no 3014 0.10499434122099 4352 3498106 SGTC_1234 0326-0494 15.5 µM -1.25622581847847 0.101126989996785 no 3015 0.104517054230519 4405 1547813 SGTC_322 k048-0136 19.3 µM -1.25733202372783 0.100917889779462 no 3016 0.104316716296446 4394 6823282 SGTC_2526 patulin 37.61 µM -1.25981750737258 0.100449221898479 no 3017 0.103867601313307 4364 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2484 5809818 12.04 µM -1.26888951759345 0.0987520633846101 no 3018 0.102240235746193 4300 2870548 SGTC_1949 st076024 69.1 µM -1.27149463454462 0.0982686081610219 no 3019 0.101776367512282 4284 2921930 SGTC_1700 st030840 7.9285 µM -1.27174888339587 0.0982215179048461 no 3020 0.101731178044942 4381 5499307 SGTC_3088 9117578 49.47 µM -1.27454574288453 0.0977045931338102 no 3021 0.101235036090532 4414 678341 SGTC_229 benomyl 22.8748 µM -1.2763735550769 0.0973678502728984 no 3022 0.100911749921476 4371 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_924 2046-0044 21.3 µM -1.27723602592125 0.097209250884343 no 3023 0.100759465861184 4332 3623589 SGTC_2459 5811157 9.22 µM -1.27956612089698 0.0967817187808451 no 3024 0.100348885667516 4302 2870684 YBR192W RIM2 SGTC_1789 tunicamycin 25 nM -1.28457053669425 0.09586816564251 no 3025 0.0994712000176489 4242 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_113 0099-0221 2.5 µM -1.28457302399627 0.0958677131694678 no 3026 0.0994707651885779 4318 89219 SGTC_1349 flufenamic acid 69 µM -1.28787813753291 0.0952678563216439 no 3027 0.0988941934633003 4295 3371 A non-steroidal anti-inflammatory. SGTC_2714 st079313 56.9 µM -1.28995273153107 0.0948927452917831 no 3028 0.0985335352123522 4342 2939799 SGTC_1966 st070145 16.1 µM -1.29038272150338 0.094815134371398 no 3029 0.0984589041370977 4345 3748532 SGTC_208 k072-0098 12.366 µM -1.29355919803279 0.0942432457146241 no 3030 0.0979088618727453 4338 5948901 SGTC_419 nsc-638432 893 µM -1.294959315875 0.0939919798027955 no 3031 0.0976671322851174 4331 368090 SGTC_3052 9092717 49.47 µM -1.29775658724604 0.0934914610064038 no 3032 0.0971854959055732 4367 25237534 SGTC_1770 st043884 66.3 µM -1.29781517197488 0.0934809994641077 no 3033 0.0971754274086278 4374 670149 SGTC_40 0327-0103 19.753 µM -1.30192864654412 0.0927486115215395 no 3034 0.0964703893345698 4205 409036 SGTC_1468 k284-1086 134 µM -1.30224519298784 0.09269242800646 no 3035 0.0964162903038739 4366 15996457 SGTC_403 arphamenine a 50 µM -1.30290302739718 0.0925757501449141 no 3036 0.0963039351281754 4359 5487158 An arginine aminopeptidase inhibitor. SGTC_2537 larixol 68.93 µM -1.30550890944644 0.0921146212304877 no 3037 0.0958598076845084 4343 6708759 SGTC_2104 5389443 200 µM -1.30588175525327 0.0920487828811331 no 3038 0.0957963859722105 4401 2244536 SGTC_2260 7964312 200 µM -1.30839392047801 0.0916060844631432 no 3039 0.0953698668124556 4427 231951 SGTC_1782 st039423 80.636 µM -1.30880005776399 0.0915346625933096 no 3040 0.0953010436964506 4402 2068169 SGTC_447 ml7 120 µM -1.31181490596875 0.0910057717736237 no 3041 0.0947912971415607 4426 4216 Selective myosin light chain kinase inhibitor. SGTC_88 0180-0332 8.668 µM -1.31226964476485 0.0909261946914414 no 3042 0.0947145852154655 4465 3101745 SGTC_2345 9052315 157.45 µM -1.31321230703988 0.0907613978117843 no 3043 0.094555709038395 4389 6469265 SGTC_148 3253-0744 288.01 µM -1.31418505683094 0.090591573492008 no 3044 0.0943919679781637 4253 6893655 SGTC_3036 9090181 49.47 µM -1.31736040665341 0.0900388572193179 no 3045 0.0938589229406332 4431 25236586 SGTC_3046 9092212 49.47 µM -1.32076394382894 0.0894492080217201 no 3046 0.0932900427626613 4453 25236637 SGTC_626 0214-0009 33 µM -1.32473808669661 0.0887643441050239 no 3047 0.0926290180611886 4437 3437874 SGTC_2677 mitomycin C 100 µM -1.32566289971077 0.0886055326372276 no 3048 0.0924756907553374 4457 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1682 st012968 530 nM -1.32794793457868 0.0882140477317897 no 3049 0.0920976538260273 4383 24207270 SGTC_414 piperonyl butoxide 100 µM -1.32822500924439 0.0881666655383793 no 3050 0.0920518923934918 4384 5794 A potent inhibitor of cytochrome P450. SGTC_2449 5812982 45.77 µM -1.3294741388234 0.087953288988556 no 3051 0.0918457961682958 4312 776185 SGTC_479 n-linoleoylglycine 10 µM -1.33250357059502 0.0874374007220053 no 3052 0.0913473844679857 4426 6433346 An anti-infammatory. SGTC_509 pifithrin 175 µM -1.33277395772625 0.0873914659492942 no 3053 0.0913029971772956 4464 4817 A p53 inhibitor. SGTC_52 0329-0193 875 nM -1.33459610552081 0.0870823796230787 no 3054 0.0910042866752055 4437 3739292 SGTC_560 2332-1943 155 µM -1.33563045294091 0.0869072895400552 no 3055 0.0908350456705089 4383 21177716 SGTC_1330 1469-0054 61.8 µM -1.33782700610142 0.0865363385486479 no 3056 0.0904764180998738 4376 7102664 SGTC_2188 6126565 140.678 µM -1.33881302416787 0.0863702065625591 no 3057 0.0903157748696443 4294 874518 SGTC_1807 st050092 58.9 µM -1.34002057599751 0.0861670738770576 no 3058 0.0901193277781508 4408 5008496 SGTC_1076 itraconazole 331 nM -1.34267264188265 0.0857222016984323 no 3059 0.0896889985627693 4390 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_908 3448-7491 47.7 µM -1.34290412879584 0.0856834525473201 no 3060 0.0896515096778784 4412 1203031 SGTC_471 1-acyl-paf 4 µM -1.34445045650513 0.0854249453463043 no 3061 0.0894013835273493 4360 16759367 SGTC_272 doxorubicin 8.13 µM -1.34723056662811 0.0849616506097693 no 3062 0.0889529931615409 4429 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_675 1309-0189 238 µM -1.34821005471237 0.0847988721494161 no 3063 0.0887954157950115 4402 4246530 SGTC_320 4092-0846 5.34 µM -1.35029591069898 0.0844530088142232 no 3064 0.0884605417738095 4359 1359356 SGTC_213 1246-0773 967 nM -1.35302132133701 0.084002694875471 no 3065 0.0880244094884095 4424 6251622 SGTC_2903 5923464 63.88 µM -1.35587310547565 0.0835334332516426 no 3066 0.0875697729815767 4417 2876576 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.35788310728775 0.0832038724704796 no 3067 0.0872503892138983 4414 5024745 SGTC_221 trifluoperazine 10.304 µM -1.36057368264047 0.0827642559859954 no 3068 0.0868242265374018 4398 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2726 cimetidine 79.27 µM -1.36105166396424 0.082686341182696 no 3069 0.0867486816081189 4386 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1519 esterone 74 µM -1.36150590740357 0.0826123470146409 no 3070 0.0866769339817394 4376 698 A steroid. SGTC_2245 6637752 200 µM -1.36398880229172 0.082208775347962 no 3071 0.0862855449770188 4440 681890 SGTC_1710 st031758 61.5 µM -1.3651087910534 0.0820272182337354 no 3072 0.0861094297054713 4441 5394341 SGTC_818 4072-2707 53.5 µM -1.37356255053567 0.0806665456259856 no 3073 0.0847887649209413 4333 882871 SGTC_2558 carylophyllene oxide 100 µM -1.37963507506058 0.0796997132005284 no 3074 0.083849516131277 4539 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3291 9121177 71.43 µM -1.38284391383735 0.079192373245945 no 3075 0.0833563653435918 4406 17015612 SGTC_962 1254-0300 21.5 µM -1.38340042426532 0.0791046344052734 no 3076 0.0832710602710036 4393 7340576 SGTC_992 3909-8734 162 µM -1.38732398713211 0.0784881374815265 no 3077 0.0826714959555679 4435 4288319 SGTC_1999 st074831 12.5 µM -1.38776987818578 0.078418307165401 no 3078 0.0826035649288669 4406 17112523 SGTC_2284 7945075 39.21 µM -1.39347845556283 0.0775284527782802 no 3079 0.0817375777757067 4388 1245402 SGTC_2228 7354201 200 µM -1.39479836371105 0.0773238008057453 no 3080 0.0815383262427735 4522 753451 SGTC_311 1315-0136 58 µM -1.39587820056417 0.0771566773320383 no 3081 0.0813755881202107 4451 6759207 SGTC_990 3985-0011 41.3 µM -1.39730415781815 0.0769364064313892 no 3082 0.0811610630281608 4402 5399565 YGL099W LSG1 SGTC_3222 9128301 49.47 µM -1.39823837723016 0.0767923547864317 no 3083 0.0810207479334041 4401 4911358 SGTC_1484 3473-2379 286 µM -1.4020081833177 0.0762131535848853 no 3084 0.08045640151559 4553 671917 SGTC_514 4466-0038 2.65 nM -1.40429833102097 0.0758629173421062 no 3085 0.0801150155364918 4228 5722064 SGTC_2688 kanamycin b 96.69 µM -1.40708972978883 0.0754376830178149 no 3086 0.0797003915595776 4440 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2792 7535235 81.82 µM -1.40868300520696 0.0751957833301851 no 3087 0.0794644611831195 4414 1281891 SGTC_385 1494-0393 12.4 µM -1.4094421240738 0.0750807380211184 no 3088 0.0793522378187655 4411 3090647 SGTC_2722 naftopidil 47.16 µM -1.4131096290025 0.0745268135391493 no 3089 0.0788117462291201 4375 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1294 1000-1494 117 µM -1.41329667562311 0.0744986466367476 no 3090 0.0787842555285263 4438 712797 YDL207W GLE1 SGTC_2332 7982454 138.89 µM -1.41601996720945 0.0740894726087637 no 3091 0.0783848292304714 4348 2981748 SGTC_643 k048-0106 28.4 µM -1.41708968140441 0.0739292186991723 no 3092 0.0782283545025641 4462 6763920 SGTC_1293 1000-1278 195 µM -1.41725598435812 0.0739043286571468 no 3093 0.0782040494756898 4458 678847 SGTC_2197 6588183 93.1375 µM -1.41798236155322 0.0737956891198735 no 3094 0.0780979572402297 4450 884136 SGTC_144 4161-2749 112.381 µM -1.41848802755061 0.073720132020198 no 3095 0.0780241658315588 4434 797501 YMR168C CEP3 SGTC_1819 st053448 58.6 µM -1.41916562799849 0.0736189770413033 no 3096 0.0779253671256185 4374 2857616 SGTC_2145 5634607 200 µM -1.41987200950552 0.0735136385184531 no 3097 0.0778224730446236 4434 308662 SGTC_2386 9075165 157.42 µM -1.42479931020204 0.0727820624983579 no 3098 0.0771076108937849 4429 16452277 SGTC_3256 9138902 49.47 µM -1.42604911377388 0.0725973884080552 no 3099 0.0769270828528205 4550 17228773 SGTC_2047 4141938 200 µM -1.42612550725384 0.072586111966745 no 3100 0.0769160586147445 4466 3807862 SGTC_376 3970-0862 59.1 µM -1.42775679292816 0.0723456379549971 no 3101 0.0766809365511331 4473 3135186 SGTC_2635 hydroquinidine 100 µM -1.43834559919046 0.0707995182352754 no 3102 0.0751680099008178 4384 442912 An experimental heart treatment. SGTC_2642 cholecalciferol 100 µM -1.44356074422049 0.0700474228583216 no 3103 0.0744312869975231 4458 9821465 A vitamin D precursor, similar to steriods. SGTC_2203 7227154 166.4 µM -1.44372819548849 0.0700233763346609 no 3104 0.0744077234914581 4487 896304 SGTC_420 mitomycin C 81.9 mM -1.44442932314991 0.069922761181161 no 3105 0.0743091236413692 4439 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1236 0330-0013 258 µM -1.45276339921601 0.0687352863770898 no 3106 0.0731447286900449 4488 4617066 SGTC_86 0417-1630 471.922 µM -1.45304977508113 0.0686947603992991 no 3107 0.0731049672397715 4441 3634867 SGTC_3348 9149464 3.537 µM -1.46108131339941 0.0675656803575905 no 3108 0.0719965638789838 4411 1951442 SGTC_1093 fluphenazine 7.97 µM -1.46144782774712 0.0675144996547693 no 3109 0.0719462916876019 4507 6602611 An atypical antipsychotic. SGTC_2304 7443016 91.4 µM -1.46440674456955 0.067102407936858 no 3110 0.0715414231959486 4419 939854 SGTC_1959 st077091 55.8 µM -1.46929015483204 0.0664265475490278 no 3111 0.0708770530100576 4484 821356 YKL052C ASK1 SGTC_195 4234-0266 16.654 µM -1.4693178869473 0.0664227245510594 no 3112 0.0708732937375707 4504 2303354 SGTC_196 k015-0023 18.111 µM -1.47240287001976 0.0659985081859265 no 3113 0.0704560593055496 4430 5211998 SGTC_2287 7945887 168.79 µM -1.47334510881137 0.0658693601958467 no 3114 0.0703290016006649 4496 1245853 SGTC_1816 st051957 91.6 µM -1.47656782115643 0.0654291192140473 no 3115 0.0698957613975311 4486 674121 SGTC_3092 9117248 49.47 µM -1.48101943133248 0.0648247613619692 no 3116 0.0693006977923611 4601 17141857 SGTC_2596 sinensetin 100 µM -1.48311344694062 0.0645419775281166 no 3117 0.0690221359567767 4494 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_296 1222-0039 74.9 µM -1.48628569795699 0.0641154113076837 no 3118 0.0686017840321388 4498 5984176 SGTC_1917 st066507 28.5 µM -1.48661654679485 0.0640710492364745 no 3119 0.0685580575205536 4434 3156428 SGTC_993 3909-8757 62.7 µM -1.48953475794987 0.0636807919660412 no 3120 0.0681733038112495 4441 4288324 YLR208W SEC13 SGTC_1393 3470-5649 58.2 µM -1.4897344893008 0.063654149325929 no 3121 0.0681470311466161 4482 4108395 SGTC_396 dithiazanine 1.25 µM -1.49159683298523 0.0634061441313281 no 3122 0.0679024344774573 4452 10578 An antihelmenthic. SGTC_226 1,3-diallylurea 8.28947 mM -1.49330187301084 0.0631797469169282 no 3123 0.0676790927642774 4459 74537 YKL182W FAS1 SGTC_2597 laccaic acid a 100 µM -1.49379009302831 0.0631150365532051 no 3124 0.0676152458765984 4469 5491415 A textile dye. SGTC_3316 9136639 10.545 µM -1.50317988979914 0.0618804975998854 no 3125 0.0663963309515835 4481 4903665 SGTC_331 k048-0133 24.5 µM -1.50500761721816 0.0616424002294065 no 3126 0.0661610591944381 4475 6813582 SGTC_2437 5741531 144.16 µM -1.50554437394448 0.0615726131852631 no 3127 0.0660920887177596 4510 2262990 SGTC_815 1582-0027 36.9 µM -1.50564784066613 0.061559167935887 no 3128 0.066078800182151 4510 3128206 SGTC_3094 9117742 49.47 µM -1.5100105083945 0.0609943336261575 no 3129 0.0655203714075767 4459 17149698 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.51147680294121 0.0608054049032635 no 3130 0.0653335072045569 4479 688761 SGTC_1197 1601-0112 267 µM -1.51280464276266 0.0606347108865724 no 3131 0.0651646445845724 4469 7350313 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.52133726497385 0.059546768656254 no 3132 0.0640876116257315 4450 6857784 SGTC_3352 9151559 45.5865 µM -1.52193313042248 0.0594713687330276 no 3133 0.0640129183901878 4505 17159339 SGTC_3082 9117008 49.47 µM -1.52659685293397 0.0588838106047678 no 3134 0.0634306450383655 4539 41448529 SGTC_1438 4092-1045 4 µM -1.52957433360969 0.0585110820306746 no 3135 0.0630610632809633 4519 1351342 SGTC_2961 9083290 32.55 µM -1.53028454607561 0.0584224500560737 no 3136 0.0629731559130626 4471 17741490 SGTC_1090 efavirenz 20.7 µM -1.53098105530919 0.0583356306341424 no 3137 0.06288703742132 4538 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2811 7967822 32.47 µM -1.53560691241998 0.0577615895008183 no 3138 0.0623174089150894 4526 2232244 SGTC_944 3370-0224 231 µM -1.53787666800123 0.0574815553989485 no 3139 0.0620393865597356 4499 4580514 SGTC_1443 4112-3303 14 µM -1.53952813079927 0.0572784760438309 no 3140 0.0618377078664609 4554 704433 SGTC_1356 1502-0781 85.8 µM -1.54253425137118 0.056910264939252 no 3141 0.0614719106602619 4523 567702 SGTC_714 4296-0578 26.1 µM -1.54294889912136 0.0568596225333307 no 3142 0.0614215875179142 4569 1589775 SGTC_3077 9117319 49.47 µM -1.54494993650474 0.056615727437983 no 3143 0.0611791866554912 4478 17154678 SGTC_125 0133-0007 11.75 µM -1.55102720933527 0.0558800537160572 no 3144 0.0604475817429656 4601 26541 SGTC_355 1311-2252 105 µM -1.55204922291045 0.0557570797444495 no 3145 0.0603252231324359 4498 5338538 SGTC_2395 5646831 180.19 µM -1.55400986665529 0.0555217628126265 no 3146 0.0600910315639903 4500 6808628 SGTC_3311 9131146 2.8755 µM -1.5571313826966 0.0551487362358937 no 3147 0.0597196477256325 4478 4900406 YPR165W RHO1 SGTC_1258 0671-0043 57.1 µM -1.56221795393664 0.054545126863068 no 3148 0.0591183262266711 4526 4298767 SGTC_541 4513-1321 94 µM -1.56482464511271 0.0542378292012693 no 3149 0.058812015695183 4493 747515 SGTC_1475 4092-1048 11.7 µM -1.56714264061444 0.0539657174894867 no 3150 0.0585406770943882 4535 2881759 SGTC_1080 nisoldipine 24.4 µM -1.56953030230265 0.0536865587263588 no 3151 0.05826221221014 4544 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3172 9105863 49.47 µM -1.57090069966844 0.0535268530479383 no 3152 0.0581028580342171 4623 2348785 SGTC_820 1582-0060 59.9 µM -1.57148980454583 0.053458314738617 no 3153 0.0580344603850054 4561 3848840 SGTC_647 0140-0236 81 µM -1.57462762248798 0.053094422058925 no 3154 0.0576712115380962 4544 990837 SGTC_1092 toremifene 6.32 µM -1.57549384015376 0.0529943135201593 no 3155 0.0575712495911965 4528 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2359 9039622 200 µM -1.58491805302321 0.0519148078345024 no 3156 0.0564924771084467 4495 6463596 SGTC_2830 7992007 71.43 µM -1.58971407459452 0.0513721912167968 no 3157 0.0559496348411911 4442 1952075 SGTC_1290 0986-0249 10.2 µM -1.59203623977767 0.0511110898402322 no 3158 0.055688280993892 4416 53329 SGTC_1046 2001-0062 216 µM -1.59311010034599 0.0509907039253661 no 3159 0.055567746938351 4487 739778 SGTC_1613 st002381 52.1 µM -1.59323508927205 0.0509767066273407 no 3160 0.0555537311119088 4550 551167 SGTC_2038 4100038 30.985 µM -1.59600356122082 0.0506674535664951 no 3161 0.0552439991243741 4501 3596803 SGTC_2673 kobusone 100 µM -1.59730565305966 0.0505225205414007 no 3162 0.0550987956593345 4644 6710676 An epoxy ketone and protein crosslinker. SGTC_2990 9074105 71.4286 µM -1.59834198116086 0.0504074053018379 no 3163 0.0549834446039814 4480 6502001 SGTC_1029 k015-0030 64.7 µM -1.60111681394357 0.050100205919 no 3164 0.0546755244034618 4555 2208316 SGTC_2587 piperic acid 92.2 µM -1.60596983243842 0.049566522149361 no 3165 0.0541402692398452 4484 5370536 SGTC_1666 st014829 29 µM -1.6147931342634 0.0486078591979931 no 3166 0.0531777502364766 4580 3858230 SGTC_2293 7624732 200 µM -1.61540241955214 0.0485422105620488 no 3167 0.0531117883109486 4456 894453 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.61592122588385 0.048486366658777 no 3168 0.0530556728944279 4631 4620898 SGTC_3211 9128781 49.47 µM -1.61864266088858 0.0481942745747216 no 3169 0.0527620852776707 4469 17194361 SGTC_77 0828-0286 12.516 µM -1.62051763690094 0.0479938534508009 no 3170 0.0525605644135387 4448 745345 SGTC_1518 st038567 90.8 µM -1.62364969235453 0.0476605482469606 no 3171 0.0522252967567064 4514 77966 SGTC_1649 st011737 51.3 µM -1.62456250821223 0.0475637584073331 no 3172 0.0521279056030007 4570 1761035 SGTC_108 0509-0257 621.132 µM -1.62736089422684 0.0472680142856369 no 3173 0.0518302359326767 4530 536624 SGTC_1833 st055984 71 µM -1.62759289194589 0.0472435621852336 no 3174 0.0518056186562141 4583 676288 SGTC_412 gemfibrozil 100 µM -1.6309557370472 0.0468902622968216 no 3175 0.0514498297832435 4510 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3221 9128209 49.47 µM -1.63174007809517 0.0468081650823605 no 3176 0.0513671266533609 4583 16460723 SGTC_1963 st076565 50.3 µM -1.63445142359666 0.0465252555828194 no 3177 0.0510820490609261 4578 4914280 SGTC_1044 1222-0021 1.78 µM -1.63540718933954 0.0464258560258085 no 3178 0.0509818581519165 4480 4306703 SGTC_980 1473-0395 201 µM -1.63665167702163 0.0462966849856955 no 3179 0.0508516356363099 4487 768876 SGTC_2417 cerulenin 830 nM -1.64073190790993 0.045875202172138 no 3180 0.0504265391811138 4564 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_114 0364-0001 490.298 µM -1.64806106485655 0.0451258570523169 no 3181 0.0496700704848426 4562 4003655 SGTC_300 r073-0011 5.04 µM -1.6485103181839 0.0450802469246377 no 3182 0.0496239975558983 4566 2735780 SGTC_1842 st055362 61.2 µM -1.65173893990378 0.0447535537623559 no 3183 0.0492938904442787 4533 676032 SGTC_1548 st061468 90.8 µM -1.66383134842091 0.0435468710621996 no 3184 0.0480730687075752 4624 390799 SGTC_1721 st082152 9.2685 µM -1.66748335974826 0.043187650060548 no 3185 0.0477091652574109 4512 5296051 SGTC_3353 9151644 39.2805 µM -1.6683422478135 0.04310351623632 no 3186 0.0476239028568822 4584 4909158 SGTC_2234 tolnaftate 200 µM -1.67358765034383 0.0425925633662902 no 3187 0.0471058336412591 4684 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2922 7999257 32.47 µM -1.67566919444053 0.0423911630575197 no 3188 0.0469015035322378 4542 2988377 SGTC_351 caspofungin 25 nM -1.68224142859632 0.0417603160919868 no 3189 0.0462610168174766 4577 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1670 st016595 4.04 µM -1.68541699992458 0.0414582394189382 no 3190 0.0459540730178917 4617 597879 SGTC_508 roscovitine 141 µM -1.68608384741427 0.0413950309543056 no 3191 0.0458898253372534 4647 160355 A CDKinase inhibitor. SGTC_1735 st034310 56.75 µM -1.68798423712628 0.0412153270801115 no 3192 0.0457071274187384 4582 871153 SGTC_441 propafenone 146 µM -1.69629600530075 0.0404367719165531 no 3193 0.0449149183144632 4574 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_976 1348-1067 47.6 µM -1.69754368471055 0.0403209405218886 no 3194 0.044796959711416 4596 5310671 YGL099W LSG1 SGTC_586 0957-0265 8.15 µM -1.70175653909785 0.0399318194092893 no 3195 0.044400508370983 4514 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1303 1160-0052 261 µM -1.70426239879777 0.0397018164604921 no 3196 0.044166038174356 4546 3562476 SGTC_2712 st079126 47.7 µM -1.70720943291442 0.0394326994432785 no 3197 0.0438915661859409 4590 3152970 SGTC_3184 9108758 49.47 µM -1.70723616585176 0.0394302650561435 no 3198 0.0438890827252259 4636 902885 SGTC_1857 st056007 79.3 µM -1.70930430526121 0.0392423039285904 no 3199 0.043697298127413 4582 619834 SGTC_1957 st077035 62.4 µM -1.71126989017525 0.0390643398595377 no 3200 0.0435156510000201 4618 705593 SGTC_2300 7976697 71.57 µM -1.71414858122552 0.0388048894814029 no 3201 0.0432507207338804 4489 2236109 SGTC_1960 st011366 51.8 µM -1.71611542723968 0.0386284301907414 no 3202 0.0430704590824432 4631 3972846 SGTC_1477 0139-0234 16 µM -1.71715728760242 0.0385352229539972 no 3203 0.0429752186494944 4616 620880 SGTC_2489 cantharidin 73.42 µM -1.72149613964219 0.0381490283486509 no 3204 0.0425804160419729 4552 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_94 0334-0113 514.748 µM -1.72431443307548 0.0378998716819215 no 3205 0.0423255475688034 4609 6795178 SGTC_2353 9059630 146.67 µM -1.72569943625485 0.0377779153004171 no 3206 0.042200749762688 4633 4779114 SGTC_3274 9138298 49.47 µM -1.72693377226187 0.0376694960149016 no 3207 0.0420897791360096 4567 17015756 SGTC_2356 9061756 188.97 µM -1.7308344210991 0.0373285467798691 no 3208 0.0417406503722737 4620 20104043 SGTC_1702 st027038 51 µM -1.73215840127383 0.0372133945189771 no 3209 0.0416226816570167 4632 5521182 SGTC_880 0833-0487 87.2 µM -1.73465908249836 0.036996691367587 no 3210 0.041400603912861 4592 76075 SGTC_3223 9129970 49.47 µM -1.73521960663936 0.0369482594583869 no 3211 0.0413509574800856 4609 17248386 SGTC_3210 9128157 49.47 µM -1.73949015646008 0.036580963405647 no 3212 0.040974291097092 4548 17590849 SGTC_1431 4049-0260 9.09 µM -1.7398638634484 0.0365489647248762 no 3213 0.0409414626487896 4634 3854841 SGTC_2956 9076196 2.52 µM -1.74253171085109 0.0363211948820041 no 3214 0.0407077238114453 4596 16423868 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.74282393816158 0.0362963164738062 no 3215 0.0406821867590142 4547 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1458 k015-0034 6.33 µM -1.74509686887383 0.0361032891763685 no 3216 0.0404840042632167 4626 3598957 SGTC_1415 3966-0071 78.1 µM -1.75067761510455 0.0356329117078221 no 3217 0.0400007287035478 4530 2893185 SGTC_2979 9012552 45.46 µM -1.75114893051894 0.0355934176252669 no 3218 0.0399601298275691 4616 17100905 SGTC_1376 2910-0861 41.3 µM -1.75142105115836 0.0355706315007556 no 3219 0.0399367047436904 4554 1112859 SGTC_2450 5739737 12.93 µM -1.75285986818799 0.0354503503036015 no 3220 0.0398130318534734 4620 2262825 SGTC_703 3875-0075 71.8 µM -1.75345266637586 0.0354008910889754 no 3221 0.0397621687862437 4651 2850814 SGTC_930 2810-3379 265 µM -1.75732143550362 0.0350794942780991 no 3222 0.0394315180647654 4596 1015764 SGTC_85 0868-0259 160.055 µM -1.75877453206854 0.0349593989581836 no 3223 0.0393079060911252 4564 83173 SGTC_2153 5569715 200 µM -1.76295877570819 0.0346154639759572 no 3224 0.038953721384161 4631 2054701 SGTC_678 1218-2179 85.9 µM -1.76984272432024 0.0340556703026023 no 3225 0.0383766721788173 4653 6820081 YOR116C RPO31 SGTC_1471 k673-0312 37 µM -1.77431650320877 0.0336958752872749 no 3226 0.0380054061396611 4618 24099884 SGTC_1943 st076331 65.2 µM -1.776892105754 0.0334901601118176 no 3227 0.0377929967443019 4600 24208415 SGTC_499 genistein 192 µM -1.77887360114606 0.0333326013248774 no 3228 0.0376302435045572 4693 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_448 monastrol 171 µM -1.78165867107739 0.0331121786673959 no 3229 0.0374024552083368 4553 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3335 9143315 29.6265 µM -1.78645091531784 0.0327357110940684 no 3230 0.0370131389916098 4638 4899691 SGTC_1448 4255-0083 152 µM -1.78654523798564 0.0327283368868931 no 3231 0.0370055096975528 4647 5399660 SGTC_2419 paclitaxel 166.5 µM -1.79052073247678 0.0324187733996762 no 3232 0.036685118668755 4558 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_748 act1.228 77.9 µM -1.79989113035175 0.0316986695733157 no 3233 0.0359389152311155 4607 4421505 YNR035C ARC35 SGTC_3161 9100388 49.47 µM -1.81405737273839 0.0306351462438409 no 3234 0.0348344466778998 4682 25236368 SGTC_1564 D-Arginine 115 µM -1.8167066829883 0.0304395677236643 no 3235 0.0346310189519718 4618 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_970 1315-0089 19.5 µM -1.81922083310047 0.0302549247860693 no 3236 0.0344388728445207 4610 6811083 YLR033W RSC58 SGTC_533 1222-0222 6.71 µM -1.81969004099008 0.0302205684524126 no 3237 0.0344031103975358 4650 3982874 SGTC_510 ag-490 170 µM -1.82521728733064 0.0298182811958747 no 3238 0.0339841230327068 4734 5328779 SGTC_3356 9151811 4.48 µM -1.82558388611121 0.0297917570356807 no 3239 0.033956482429069 4662 1859254 YPR165W RHO1 SGTC_1300 1094-0077 113 µM -1.82909977241365 0.0295383682779192 no 3240 0.0336923315339666 4622 5532636 SGTC_3169 9102970 49.47 µM -1.83353026945455 0.0292216138838742 no 3241 0.0333618756741786 4697 17027839 SGTC_3220 9131269 49.47 µM -1.83656995897367 0.0290059299877607 no 3242 0.0331367027689664 4633 17722206 SGTC_2040 5100729 123 µM -1.83684205388583 0.0289866879278065 no 3243 0.0331166078309315 4663 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_324 1315-0088 19.6 µM -1.83770641579452 0.0289256321799892 no 3244 0.0330528389832245 4626 6787421 SGTC_2244 6635614 200 µM -1.84219220484798 0.028610484834268 no 3245 0.0327235201349343 4603 836499 SGTC_596 1155-0152 116 µM -1.8449313308462 0.0284194566958932 no 3246 0.0325237641811287 4664 280313 SGTC_1645 Cervolide 78 µM -1.8484344847502 0.0281766925766825 no 3247 0.0322697569398952 4671 23173 A fragrance. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.85376522383143 0.0278105931779816 no 3248 0.0318863778936739 4629 16623 A steroid. SGTC_3279 9140807 49.47 µM -1.86942497382576 0.0267579816477654 no 3249 0.0307818563726397 4693 45595718 SGTC_613 3914-0030 117 µM -1.869881398973 0.0267278078011607 no 3250 0.0307501447047511 4413 1145395 SGTC_1228 0124-0032 52.5 µM -1.87159211278755 0.0266149668229307 no 3251 0.0306315277107701 4658 X1228 SGTC_755 1995-0008 37.3 µM -1.8746412527437 0.0264148282754434 no 3252 0.0304210469537845 4644 689533 SGTC_2762 leflunomide 42.06 µM -1.8761207159473 0.02631817381987 no 3253 0.030319352844508 4617 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2280 7785178 200 µM -1.87750170461112 0.0262282197253263 no 3254 0.0302246819648037 4640 2954328 SGTC_2152 5568786 200 µM -1.88741657754353 0.025589909545794 no 3255 0.029552158567868 4684 5399883 SGTC_1316 1272-0050 65.9 µM -1.88874922097654 0.0255051151138289 no 3256 0.0294627199164141 4664 7340392 SGTC_2771 fluoxetine 41.05 µM -1.89471427714 0.025128444495133 no 3257 0.0290651326156178 4649 3386 A selective serotonin reuptake inhibitor. SGTC_3321 9137793 26.8275 µM -1.89844264018427 0.0248953887681891 no 3258 0.0288188985425103 4655 4904192 SGTC_1986 st071812 45 µM -1.90023384782998 0.024784068620528 no 3259 0.0287012191085182 4613 11838594 SGTC_921 1561-0023 372 µM -1.90043694725617 0.0247714727731315 no 3260 0.0286879010645777 4629 24050882 SGTC_2904 7225135 42.03 µM -1.90292963169671 0.0246173180263216 no 3261 0.0285248639331979 4698 4446116 SGTC_3098 9119039 49.47 µM -1.91285778857062 0.0240112974696723 no 3262 0.0278831303534164 4656 17161528 SGTC_2974 9094440 9.66 µM -1.91518611868418 0.0238710039316593 no 3263 0.0277343860646122 4630 25236134 SGTC_569 4130-2812 160 µM -1.91778540448214 0.0237151985406468 no 3264 0.0275691136061847 4586 743552 SGTC_1626 st003712 1.76 µM -1.92766803323906 0.02313060196146 no 3265 0.0269482153389576 4654 24207035 SGTC_1602 st001878 87.6 µM -1.94754960436407 0.0219912359029516 no 3266 0.0257344394259525 4644 595405 YLR310C CDC25 SGTC_3267 9137951 49.47 µM -1.95001321210435 0.0218534086823476 no 3267 0.0255872721603062 4695 16643986 SGTC_360 0957-0399 1.01 µM -1.96165696167939 0.021211828331798 no 3268 0.0249012178589516 4671 6752301 YPR165W RHO1 SGTC_1198 1612-1005 86.7 µM -1.97085268319869 0.0207164624501476 no 3269 0.0243703643239655 4708 6998509 SGTC_530 4358-1714 28 µM -1.97176587989057 0.0206678084242526 no 3270 0.0243181695320893 4675 1564641 SGTC_2222 6885208 172.143 µM -1.97286779906932 0.0206092283689038 no 3271 0.024255313091719 4707 609514 SGTC_1526 st051518 75 µM -1.97690969713986 0.0203955562884957 no 3272 0.0240259192550087 4645 673993 SGTC_408 cantharidin 100 µM -1.98188994203671 0.0201348638159695 no 3273 0.0237457799480164 4677 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2912 7964298 10.93 µM -1.98775613911579 0.0198314257587866 no 3274 0.0234193333827149 4656 2975850 SGTC_555 4296-0685 37 µM -1.98945512457118 0.0197442712615911 no 3275 0.0233254951657281 4665 2908540 YHR072W ERG7 SGTC_105 0111-0055 734.78 µM -1.99952566463606 0.0192343215255837 no 3276 0.0227757539234564 4695 5179370 SGTC_3163 9099914 49.47 µM -2.00539684207244 0.0189422164018429 no 3277 0.0224603195247596 4748 16268368 SGTC_1052 3253-3998 198 µM -2.00715279836434 0.0188555897798218 no 3278 0.0223666978980394 4657 5450317 SGTC_1354 1498-1681 81 µM -2.00906394733024 0.0187616903045741 no 3279 0.0222651762351938 4709 5754243 SGTC_750 4073-0104 132 µM -2.01420253081091 0.0185111901604376 no 3280 0.0219941370493746 4398 22330957 SGTC_1244 0416-0015 52.5 µM -2.01485095976302 0.0184797832708396 no 3281 0.0219601338385178 4659 96201 SGTC_684 1140-0066 328 µM -2.01768617233479 0.0183429911745817 no 3282 0.0218119779199822 4697 6813534 SGTC_34 0469-0683 81.75 µM -2.01907569816845 0.0182762655191434 no 3283 0.0217396761394936 4672 3690923 SGTC_773 4358-1457 44.6 µM -2.03190544695041 0.0176698866063253 no 3284 0.0210816145074206 4683 1186886 SGTC_2465 5809242 33.21 µM -2.03870358003084 0.0173556003825962 no 3285 0.020739810124695 4733 2731748 SGTC_1870 st057514 26.5 µM -2.04081788053688 0.0172588321620705 no 3286 0.0206344663081776 4693 5393161 SGTC_2580 diallyl disulphide 81.36 µM -2.04684621364351 0.0169854517089078 no 3287 0.0203365932616033 4658 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1808 st050063 61.5 µM -2.04812789924044 0.0169278078674978 no 3288 0.0202737344311674 4669 4011993 SGTC_2012 4023501 200 µM -2.05360874077768 0.01668319017901 no 3289 0.0200067877399809 4674 3477460 SGTC_112 phenothiazine 287.218 µM -2.05732925022304 0.0165188673446125 no 3290 0.0198272827841477 4679 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1865 st057639 52.2 µM -2.05861879101663 0.0164622367459339 no 3291 0.0197653856044632 4705 688818 SGTC_2416 tofa 880 nM -2.06001801880923 0.0164009773016035 no 3292 0.0196984091339408 4662 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1146 3579-1023 7 µM -2.08444519936478 0.0153625701944256 no 3293 0.0185598450304195 4713 X1146 SGTC_78 0336-0123 156.75 µM -2.09346825948233 0.0149935388496854 no 3294 0.0181536872996608 4597 6765896 SGTC_1554 st069299 38.7 µM -2.13209223655877 0.0134987370093388 no 3295 0.0164996323628513 4682 24207999 SGTC_1947 st076332 61.6 µM -2.13294915546378 0.0134670871827647 no 3296 0.016464448673539 4611 24208416 SGTC_3355 9151058 44.0485 µM -2.13429239416315 0.0134176043278468 no 3297 0.0164094267428713 4711 17015728 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.14333609070458 0.0130885174944612 no 3298 0.0160430604087935 4700 61125 An anti-inflammatory. SGTC_2173 5763948 167 µM -2.14337006875707 0.013087294356529 no 3299 0.0160416972630766 4699 2867177 SGTC_1713 st033146 12.748 µM -2.1786395660758 0.0118697682901578 no 3300 0.0146792272436902 4687 674619 SGTC_82 0054-0107 293.755 µM -2.19353531243128 0.0113858360204805 no 3301 0.0141344166341013 4706 3104697 SGTC_543 3844-1095 191 µM -2.21914448102639 0.0105938534523751 no 3302 0.0132384483623161 4730 4230703 SGTC_1614 st002383 48.6 µM -2.21993574617904 0.0105701669853659 no 3303 0.0132115647865232 4754 1947235 SGTC_2404 5161160 200 µM -2.23203868305361 0.0102135748365392 no 3304 0.012806203196085 4701 2831543 SGTC_257 daunorubicin 18.5 µM -2.24540351264447 0.0098320365917983 no 3305 0.0123711200620448 4746 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_721 1187-1332 279 µM -2.26248471079815 0.00936256554371026 no 3306 0.0118337362063841 4738 25730 SGTC_1549 4'-methoxyflavonol 74.6 µM -2.26667117688524 0.00925053870464954 no 3307 0.011705160216466 4760 97141 SGTC_47 0149-0135 24.25 µM -2.2825076547584 0.00883730879713093 no 3308 0.0112296930355765 4716 5239155 SGTC_2815 7968870 71.43 µM -2.29507427526967 0.00852100407025954 no 3309 0.0108644340223157 4687 2977326 YHR190W ERG9 SGTC_3035 9091303 49.47 µM -2.30069499266053 0.00838277444563383 no 3310 0.0107044386662883 4762 25237002 SGTC_392 N-ethylmaleimide 8.33 µM -2.31830725378058 0.00796230528150958 no 3311 0.0102163142367283 4729 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1459 k035-0031 35.7 µM -2.32777483384833 0.00774403474252998 no 3312 0.00996203153221126 4605 3877128 YMR208W ERG12 SGTC_3285 9112818 20.8695 µM -2.35772751106158 0.00708778291864738 no 3313 0.00919359213504554 4747 17017947 YPR165W RHO1 SGTC_2007 4011539 71.82 µM -2.38065322507185 0.00661914857653503 no 3314 0.0086409860480008 4741 45595301 SGTC_2414 st077232 92.9 µM -2.38364224345324 0.0065601130134655 no 3315 0.00857112909623295 4708 729801 SGTC_1440 4100-1550 40 µM -2.39994260782042 0.00624628898698689 no 3316 0.00819882128402112 4762 742806 SGTC_3301 9125354 19.7965 µM -2.43554338936015 0.00560670153010818 no 3317 0.00743472058375832 4742 41905162 SGTC_1429 4049-0205 9.46 µM -2.49379346517708 0.00468497152428362 no 3318 0.00631930302006865 4787 22774478 SGTC_2565 isoliquiritigenin 100 µM -2.52498738308157 0.00424915832254297 no 3319 0.00578512215736606 4724 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3302 9125395 16.351 µM -2.53186879970053 0.00415804279107576 no 3320 0.0056728217359373 4735 17599668 SGTC_2132 5317594 122.667 µM -2.54906300999018 0.00393797195709116 no 3321 0.00540063914344184 4732 794577 SGTC_1722 st034304 3.6505 µM -2.5683914665104 0.00370308886770623 no 3322 0.00510858506335822 4727 4036148 YLR033W RSC58 SGTC_3099 9120367 49.47 µM -2.57072911124561 0.00367555042929109 no 3323 0.00507423369404507 4781 24824940 SGTC_365 0121-0052 13.6 µM -2.6250200330865 0.00308555076360079 no 3324 0.00433219346508417 4741 3101739 SGTC_1425 4048-4433 7.33 µM -2.65502009709571 0.00279746581794103 no 3325 0.00396518418538239 4790 23734946 SGTC_2039 Aminomethylbenzodioxan 200 µM -2.65683266145238 0.00278086371797668 no 3326 0.00394392927973575 4788 15053 SGTC_1447 4239-0816 81.9 µM -2.67805574376036 0.00259298155245595 no 3327 0.00370254465881989 4785 1341554 SGTC_2171 5739187 198.077 µM -2.71032394375807 0.00232923364903128 no 3328 0.00336087614308296 4765 2262761 SGTC_264 promethazine 12.5 mM -2.72413191868824 0.00222398735158437 no 3329 0.0032235374676602 4720 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1673 st016611 27.3 µM -2.81070424821072 0.00165666944187469 no 3330 0.00247166010673698 4770 5226799 SGTC_3320 9137005 35.139 µM -2.81401132740589 0.00163787911781996 no 3331 0.0024463752134912 4787 4908713 SGTC_1910 st062352 60.4 µM -2.83748022812292 0.00151001287813007 no 3332 0.00227355814878992 4756 2245730 SGTC_1864 st057645 30.4 µM -2.84504197917223 0.00147079601223304 no 3333 0.00222027852044746 4801 688666 SGTC_3351 9150312 21.596 µM -2.84543472795876 0.00146878475284521 no 3334 0.00221754239990815 4769 4904905 SGTC_76 0433-0009 400.328 µM -2.87374803888967 0.00133023525779547 no 3335 0.00202816211887345 4783 2841569 SGTC_3171 9103192 49.47 µM -2.91002424795609 0.00117018988851515 no 3336 0.00180700358167293 4803 13018434 SGTC_2168 5727979 200 µM -2.91494843417148 0.00114987987906417 no 3337 0.00177873658333802 4776 695210 SGTC_1460 k062-0059 9.15 µM -2.9155863856943 0.00114727237938611 no 3338 0.00177510404432769 4661 1373085 SGTC_3208 9114115 49.47 µM -2.92144140490906 0.00112359288844981 no 3339 0.00174207903660602 4753 650895 SGTC_1065 prochlorperazine maleate 2.48 µM -2.92625670563813 0.00110445485149477 no 3340 0.00171533862699165 4790 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1623 st003709 20.3 µM -2.96804988021882 0.000950476841865729 yes 3341 0.00149847846005783 4782 16192618 SGTC_2907 7721985 69.9 µM -3.02057684258268 0.000784948366846224 yes 3342 0.00126146840359591 4778 3267881 SGTC_67 0335-0847 266 µM -3.02193720637207 0.0007810375841656 yes 3343 0.0012558132202853 4767 4552207 YOR254C SEC63 SGTC_407 eburnamonine 100 µM -3.05130964428995 0.000700853019529936 yes 3344 0.00113922735094549 4755 3195 SGTC_1659 st012954 42.1 µM -3.06657062869903 0.000662255826067852 yes 3345 0.00108264823193656 4799 24207262 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -3.10326382389422 0.000577341061034353 yes 3346 0.000956994668361721 4801 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_363 0455-0021 3.06 µM -3.19493909067446 0.000407197600311883 yes 3347 0.000699301770645706 4765 4597466 SGTC_277 nystatin 15.5 µM -3.22954658683744 0.000356079903303812 yes 3348 0.000619933396350279 4799 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1190 1486-1332 13 µM -3.43545362081065 0.000156081291469383 yes 3349 0.000295781355137873 4803 4150046 SGTC_3201 9113999 49.47 µM -3.47656886122354 0.000131657830757989 yes 3350 0.000253936894424673 4790 16649224 SGTC_140 0062-0056 502.533 µM -3.47814268436769 0.000130798267072984 yes 3351 0.000252450543476457 4773 3758964 SGTC_1439 4092-1168 46 µM -3.54442623729066 9.90230954591272e-05 yes 3352 0.00019673429236588 4809 2886240 SGTC_1461 k072-0203 53.8 µM -4.60840369516391 5.89884356100815e-07 yes 3353 2.02886121276177e-06 4673 5418714 SGTC_3206 9114350 49.47 µM -5.14359582231757 2.79905121287046e-08 yes 3354 1.34764539440518e-07 4800 17087243 SGTC_1463 k081-0032 34.1 µM -9.34653171547721 1.62720390666029e-23 yes 3355 4.52844586773636e-21 4672 977755 SGTC_1462 k081-0014 26.5 µM -10.143343231347 2.22314344584083e-27 yes 3356 1.77373287707332e-24 4672 3270634