SGTCid condition conc unit KRE9|YJL174W.score KRE9|YJL174W.strain.pval KRE9|YJL174W.strain.significant KRE9|YJL174W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3199 9111318 49.47 µM 11.9422602743907 1.14609351556255e-34 yes 1 3.56300045597237e-33 1 8548020
SGTC_663 1486-0733 13.9 µM 7.65965567817513 2.26414451615618e-15 yes 2 9.32161177778628e-15 3 722445 YPR165W RHO1
SGTC_1016 4226-1401 38 µM 6.10550316869566 2.07996552260477e-10 yes 3 5.12386607848342e-10 7 2901613
SGTC_2486 5283202 22.39 µM 5.15767880468565 6.55403271503433e-08 yes 4 1.25015022331049e-07 1 1377751
SGTC_341 1486-1430 230 µM 4.89187155225315 2.7910616714832e-07 yes 5 4.99408119072777e-07 15 2054753 YPL210C SRP72
SGTC_1482 3346-2049 8.48 µM 4.63731625601154 1.04523978383375e-06 yes 6 1.76481071116663e-06 3 3826804
SGTC_2286 7945697 125 µM 4.61768869782833 1.15411431185577e-06 yes 7 1.94018889529909e-06 7 1245733
SGTC_800 3448-7362 155 µM 4.55498769044576 1.57974178018341e-06 yes 8 2.61943230338325e-06 38 15991913
SGTC_1020 4335-0961 93.3 µM 4.46422180179775 2.47111407782458e-06 yes 9 4.01801427309281e-06 5 669075
SGTC_2713 st079149 53.4 µM 4.4366921055963 2.82561664576672e-06 yes 10 4.56759053588938e-06 2 3103253
SGTC_1983 st071813 46.9 µM 4.36776938223953 3.93928303391484e-06 yes 11 6.27609649286431e-06 4 11838595
SGTC_194 1486-1323 56.904 µM 4.3079466437881 5.2358053769873e-06 yes 12 8.23885599274415e-06 6 5178754
SGTC_1023 4482-3888 16 µM 4.21404689419473 8.12424487219165e-06 yes 13 1.25417584898097e-05 8 3303168
SGTC_2758 dehydroepiandrosterone 69.35 µM 4.14806678386234 1.10039532173681e-05 yes 14 1.67647299817103e-05 5 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_786 4544-0069 423 µM 4.14793758547279 1.10104454253789e-05 yes 15 1.6774191234661e-05 7 748821 YLR208W SEC13
SGTC_2007 4011539 71.82 µM 4.04727703668386 1.73447315557167e-05 yes 16 2.59084501341276e-05 9 45595301
SGTC_1158 4092-0494 91.8 µM 3.94848672110533 2.68272032003452e-05 yes 17 3.93233888263909e-05 4 1148199
SGTC_1500 4488-1866 171 µM 3.92143473826226 3.01787711465228e-05 yes 18 4.40116448724326e-05 2 2900003
SGTC_150 3970-0969 77.2 µM 3.91597483393837 3.09016594496238e-05 yes 19 4.50198203545266e-05 15 6615640
SGTC_1930 st074634 34.3 µM 3.89700209040702 3.35431811596891e-05 yes 20 4.86953894159195e-05 16 684253 YOR116C RPO31
SGTC_1045 1348-1485 165 µM 3.83721015210788 4.33356567048489e-05 yes 21 6.22199880280706e-05 4 6810614
SGTC_847 0342-0274 5.54 µM 3.79117069723032 5.26555542718394e-05 yes 22 7.4969427532105e-05 4 18097
SGTC_3202 9113761 49.47 µM 3.70528473120299 7.5302441298252e-05 yes 23 0.00010557669921065 12 4798415
SGTC_1167 k781-0610 148 µM 3.70058237259801 7.6775619881471e-05 yes 24 0.00010755261943526 9 4525169
SGTC_120 rhodamine 6G 52.259 µM 3.56595260400114 0.000132457218072604 yes 25 0.000181268446600439 21 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1026 k007-1105 30.6 µM 3.53056000061176 0.000152420591152033 yes 26 0.000207340474706939 29 7066794
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.43762378408446 0.000219063871973654 yes 27 0.000293421212288921 6 6312947
SGTC_1806 st050005 60.3 µM 3.32968061596653 0.00033027621595197 yes 28 0.000434728265475071 4 5194765
SGTC_1339 1486-1321 22.7 µM 3.31712636812252 0.000346171076799553 yes 29 0.000454742353101039 13 3469382
SGTC_785 1270-0111 65.3 µM 3.19644667876677 0.000539608651446688 yes 30 0.000695657696977793 17 6741994
SGTC_286 k060-0067 22.9 µM 3.18691770864396 0.000558517186718031 yes 31 0.000718988407360061 15 5985051
SGTC_3345 9148410 3.559 µM 3.10843549016877 0.000739192421873587 yes 32 0.000940403504291092 4 4903596
SGTC_1354 1498-1681 81 µM 3.08750770483328 0.000795741677775845 yes 33 0.00100921269616232 19 5754243
SGTC_2955 9076254 12.21 µM 3.06435805343769 0.000862916157046671 yes 34 0.00109068831777184 16 16459619
SGTC_2749 bexarotene 57.39 µM 3.0618733562737 0.000870427829422993 yes 35 0.00109978246257294 17 82146 An retinoic acid receptor inhibitor.
SGTC_2439 5492030 7.2 µM 3.04943632712826 0.000908938883663076 yes 36 0.00114635613746834 17 5722370
SGTC_583 1488-1091 88.9 µM 2.99676784771765 0.00109000647068704 no 37 0.00136429208848537 20 4303273
SGTC_316 k060-0003 58.6 µM 2.98434595930597 0.00113727319647149 no 38 0.0014209262650935 16 6152314
SGTC_1817 st052116 64.4 µM 2.96375920842956 0.00121975953360905 no 39 0.00151952994620066 10 4361398
SGTC_2692 st077426 47.7 µM 2.94636072213895 0.00129370163498531 no 40 0.00160768592904599 19 25238571
SGTC_772 k072-0172 35.3 µM 2.92663819696559 0.00138246214209775 no 41 0.00171323617918575 10 5861980
SGTC_321 4534-3890 65.3 µM 2.91432211061475 0.0014406761682086 no 42 0.00178230948946255 17 699746
SGTC_1388 3346-4487 254 µM 2.8556333960868 0.00175002927444647 no 43 0.00214755378789486 9 3345614
SGTC_671 0560-0003 407 µM 2.84471660965474 0.00181383979247965 no 44 0.00222254755381501 8 3238678
SGTC_2902 5787006 60.46 µM 2.77786541123447 0.00225293512277027 no 45 0.00273586386788556 19 591003
SGTC_1908 st060353 56.5 µM 2.75864132684251 0.00239593193153931 no 46 0.00290211007692083 25 4227716
SGTC_565 1418-0001 44.5 µM 2.74154819590211 0.0025299225477016 no 47 0.00305751944602718 19 2862145
SGTC_203 k066-0004 30.888 µM 2.73304916346197 0.00259903525821808 no 48 0.00313754824705812 29 6795412
SGTC_975 1335-0046 28.5 µM 2.72834658402251 0.00263800469997232 no 49 0.00318263454707796 24 16486740
SGTC_1970 st070122 35.8 µM 2.71832448269596 0.00272282236337296 no 50 0.0032806728425751 31 102928
SGTC_856 0433-0016 11.3 µM 2.71356761581407 0.00276393514031149 no 51 0.00332814913690624 17 3911780
SGTC_87 0100-0052 35.5 µM 2.69510723716878 0.00292884333081086 no 52 0.00351829902996226 41 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2067 5224629 34.075 µM 2.69044346969536 0.00297188465327609 no 53 0.0035678561751092 25 2835000
SGTC_2083 5306046 65.942 µM 2.67450216060486 0.0031233425672332 no 54 0.00374201469898651 18 539837
SGTC_2068 5226020 147 µM 2.65627362749379 0.00330502017136743 no 55 0.00395047384163945 24 1810509
SGTC_2694 st077685 81.9 µM 2.64004887515492 0.00347466053428387 no 56 0.0041447035818576 20 2838096
SGTC_1305 1181-0477 144 µM 2.63709683535541 0.0035063538217122 no 57 0.00418094787517784 21 6252086
SGTC_685 1278-0033 54.9 µM 2.63171208260061 0.00356483421714316 no 58 0.00424779122980533 28 3590572
SGTC_2009 4012297 12.05 µM 2.62691237152848 0.00361769732712638 no 59 0.00430817598954625 28 45595307
SGTC_919 tnp00227 403.569 nM 2.6086056474068 0.00382584257601164 no 60 0.00454559719085139 27 1269246 A methoxyflavone. YNL221C POP1
SGTC_959 1222-0044 107 µM 2.59135260435183 0.00403176679630354 no 61 0.0047799742053431 19 6083612
SGTC_2939 9044578 71.43 µM 2.58879424452613 0.00406313269214501 no 62 0.0048156311700298 20 2653634
SGTC_1427 4048-4900 550 nM 2.58755498465056 0.00407840459706438 no 63 0.00483298837200176 18 24132586
SGTC_214 4373-3496 70 µM 2.58630535640501 0.00409385627894708 no 64 0.00485054724429725 47 3779166
SGTC_1039 k821-0043 94 µM 2.56181149504329 0.00440748931806444 no 65 0.00520639091590874 23 15992768
SGTC_3354 9151612 71.43 µM 2.56165166487963 0.00440960450199612 no 66 0.00520878724711386 12 27261949
SGTC_1147 3809-1045 12.3 µM 2.5598148406834 0.00443397811621326 no 67 0.00523639725278023 31 325925
SGTC_500 h-89 112 µM 2.54883080196477 0.00458225779091214 no 68 0.00540423625056519 34 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_790 1575-0012 79.1 µM 2.5483873450449 0.00458833614620146 no 69 0.00541111170724407 24 378741 YLR208W SEC13
SGTC_377 3970-0964 33.1 µM 2.53828461247946 0.00472877543878761 no 70 0.00556986747820529 27 16481235
SGTC_859 0439-0102 54.6 µM 2.53105676809279 0.00483159039285518 no 71 0.0056859720937383 37 610143
SGTC_3303 9125618 40.5795 µM 2.51158425752643 0.0051185685910783 no 72 0.00600952950639016 34 22695467
SGTC_2937 9044753 11.33 µM 2.50955149153433 0.0051493844375653 no 73 0.00604422950183873 31 6465530 YGL099W LSG1
SGTC_2506 ethyl hematommate 54.16 µM 2.50897967449802 0.00515808264013173 no 74 0.00605402255946857 22 3940691 An allergen.
SGTC_2102 5377816 72.7585 µM 2.49133602246202 0.00543297666378038 no 75 0.00636318482723865 32 1379702
SGTC_3045 9092950 49.47 µM 2.48896563804234 0.00547088334592579 no 76 0.00640576737656209 16 44120432
SGTC_1976 st070609 63.5 µM 2.47605833946349 0.00568144729163683 no 77 0.006642093476173 22 682556
SGTC_1614 st002383 48.6 µM 2.46666207848032 0.00583922801740875 no 78 0.00681894963432439 16 1947235
SGTC_584 0986-0246 15.4 µM 2.43840846790067 0.00633732602166705 no 79 0.00737604707299972 72 53315 YDR232W HEM1
SGTC_2505 galangin 7.89 µM 2.42850350913538 0.00652064780044171 no 80 0.00758063919693714 37 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_632 0781-2353 4.65 µM 2.42375265692716 0.00661022971559786 no 81 0.00768053189768842 50 6811515 YHR007C ERG11
SGTC_576 1073-0113 22.7 µM 2.42239083131723 0.00663610810835154 no 82 0.00770937886716923 74 5439563
SGTC_2862 9027634 71.43 µM 2.41688271095703 0.00674169336687846 no 83 0.00782703017873114 27 5012562
SGTC_2778 tioconazole 65.09 nM 2.38987672460621 0.00728114175623113 no 84 0.00842701442723107 72 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_791 1348-1292 225 µM 2.38627631713472 0.00735586239250343 no 85 0.00850997882529087 25 5437054
SGTC_585 0kpi-0023 191 µM 2.3754765134687 0.00758406445642966 no 86 0.00876315387267753 17 64601
SGTC_1772 st048439 82.2 µM 2.37292693535109 0.00763883867733272 no 87 0.00882387726434136 33 2927068 YDL195W SEC31
SGTC_90 0870-0863 4.608 µM 2.37180900481449 0.00766296553236405 no 88 0.00885061915661974 34 1738164
SGTC_954 1189-0853 2.85 µM 2.36429063693502 0.00782697446686016 no 89 0.00903231728920923 33 2828194
SGTC_1681 tripelennamine 100 µM 2.36384739508823 0.00783673922334127 no 90 0.00904313047070474 36 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_708 3448-5400 146 µM 2.35282451191949 0.00808304862196428 no 91 0.00931571233962518 73 3462195
SGTC_1745 st081495 74 µM 2.33254127181931 0.00855410753284963 no 92 0.00983611717984474 70 13842402 YBL026W LSM2
SGTC_1914 st062367 72.6 µM 2.32546620482364 0.00872399508747133 no 93 0.0100235224851845 37 978205
SGTC_2096 5468907 200 µM 2.32457353300309 0.00874563885428356 no 94 0.0100473876994537 33 759785
SGTC_1067 clotrimazole 1.36 µM 2.30014564713946 0.00935647339831866 no 95 0.0107199849606364 59 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_918 glabranin 770.725 nM 2.2967520349826 0.0094442194753116 no 96 0.0108164595981947 29 124049 Also referred to as licorice root.
SGTC_1735 st034310 56.75 µM 2.2654742939693 0.0102874125739209 no 97 0.0117417948761674 43 871153
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.25967574737714 0.0104507464465657 no 98 0.0119206912915241 46 165521
SGTC_319 1348-1596 45.5 µM 2.24382154976889 0.0109089173469171 no 99 0.0124219426480182 33 5380505
SGTC_2658 polymyxin b sulfate 77.05 µM 2.24204463457098 0.0109613419892333 no 100 0.0124792438542158 49 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_136 0097-0015 404.482 µM 2.21999794559551 0.0116302451524093 no 101 0.0132094535354716 38 4861337
SGTC_232 clozapine 119 µM 2.21372679666323 0.0118268729457291 no 102 0.0134237892091189 30 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_777 1315-0167 517 µM 2.19787190063565 0.0123369055050741 no 103 0.01397911791426 34 4221767
SGTC_475 α-linolenic acid 10 µM 2.18724570012841 0.0126893068086645 no 104 0.0143622961732891 50 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1942 st076330 65.2 µM 2.18700366192574 0.0126974340637712 no 105 0.014371128335599 37 24208414
SGTC_1774 st048371 48.465 µM 2.18224101683615 0.0128582748529329 no 106 0.0145458747973509 52 4242727
SGTC_1923 st058458 19.1 µM 2.18193512305782 0.0128686652470303 no 107 0.0145571605964784 51 3534982
SGTC_337 1315-0038 354 µM 2.17335151947452 0.0131632027699607 no 108 0.0148769353458826 30 1626437
SGTC_1359 1582-0056 520 nM 2.16899206569356 0.0133150109498111 no 109 0.0150416431434657 38 3661189
SGTC_1884 5633444 25 µM 2.16143512317683 0.0135817484225138 no 110 0.0153308717050897 57 5724239
SGTC_1848 st056003 16.4 µM 2.15994907449542 0.0136347406517786 no 111 0.0153883060585219 44 146492
SGTC_3205 9113483 49.47 µM 2.15739382969644 0.0137262774184835 no 112 0.0154874957957131 38 17018033
SGTC_198 3454-2873 16.191 µM 2.15229416239114 0.0139105490491246 no 113 0.0156870966559041 37 710957
SGTC_2397 5161689 200 µM 2.14284897527115 0.0142574797552375 no 114 0.0160626136257767 43 2259942
SGTC_2168 5727979 200 µM 2.13573018537531 0.0145238614114599 no 115 0.0163507062660751 43 695210
SGTC_3003 9075612 71.4286 µM 2.13502010556368 0.0145506657135408 no 116 0.016379683932503 41 6501993
SGTC_1844 rapamycin 4 nM 2.13203074864143 0.0146639762378618 no 117 0.016502159429121 110 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_409 arachidonic acid 100 µM 2.11881461053705 0.0151740716303955 no 118 0.0170530687520403 36 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_60 0986-0278 202 µM 2.11121229322531 0.0154743442727678 no 119 0.0173770343300063 35 3110598
SGTC_1312 1218-2183 165 µM 2.10848161106131 0.0155834375482007 no 120 0.0174946758685836 42 6744073
SGTC_1613 st002381 52.1 µM 2.10736377797049 0.0156282860366266 no 121 0.0175430294336119 46 551167
SGTC_3058 9093861 49.47 µM 2.09482910373176 0.0161388193897508 no 122 0.0180930934779774 51 17217477
SGTC_1789 tunicamycin 25 nM 2.0928712246518 0.0162198398145058 no 123 0.0181803257903095 61 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_419 nsc-638432 893 µM 2.07608695887328 0.0169288098995415 no 124 0.0189429545457115 41 368090
SGTC_464 bw-b 70c 158 µM 2.07453255549614 0.0169957888797732 no 125 0.0190149392442603 56 5353454
SGTC_1530 rhein 70.4 µM 2.06529202886047 0.0173986556464805 no 126 0.0194476886678189 38 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1948 st076329 66.6 µM 2.05669869767634 0.0177805965760775 no 127 0.0198576087640926 30 24208413
SGTC_562 3772-2733 112 µM 2.04389678866012 0.0183628468536103 no 128 0.0204818722339611 42 2876874 YIL048W NEO1
SGTC_575 k072-0246 11.9 µM 2.03339390092783 0.0188525889777481 no 129 0.0210063715230283 44 6796779
SGTC_3173 9105693 49.47 µM 2.03235829237786 0.0189014750669361 no 130 0.0210586985757874 34 17096658
SGTC_265 mycophenolic acid 32.932 µM 2.02397891465304 0.0193010056448296 no 131 0.0214861606490137 39 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_481 bay k-8644 50 µM 2.02322738527261 0.0193371868814869 no 132 0.0215248547434371 42 2303 A calcium channel antagonist.
SGTC_3203 9113543 49.47 µM 2.02115759512181 0.0194371318430134 no 133 0.0216317268965348 63 17018012
SGTC_1633 st005664 67.9 µM 2.01698520812271 0.0196399403607137 no 134 0.0218485284877165 52 2063822
SGTC_2252 omeprazole 400 µM 2.00999140654049 0.0199839201539388 no 135 0.0222160491925995 27 4594 A proton pump inhibitor.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.00915860729723 0.0200252186744741 no 136 0.02226015794849 49 688664
SGTC_2595 hexamethylquercetagetin 100 µM 2.00393866298277 0.0202857281705413 no 137 0.0225383156440427 63 386331
SGTC_1897 st060201 15 µM 2.00236075410883 0.0203650394632137 no 138 0.0226229730974004 45 611878
SGTC_1820 st053765 18.6 µM 1.97627966894639 0.021714516578607 no 139 0.0240615554849122 42 3690829
SGTC_1440 4100-1550 40 µM 1.96932084584023 0.022087089437027 no 140 0.0244581294303806 41 742806
SGTC_905 2-aminofluorene 215 µM 1.96344176164331 0.0224060447408852 no 141 0.0247974326495039 41 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.96335563438667 0.0224107460855641 no 142 0.0248024325608172 72 6728940
SGTC_767 0929-0023 86 µM 1.96170463539546 0.022501028520856 no 143 0.0248984409292053 76 1204563
SGTC_2049 5262831 67.185 µM 1.95757006455152 0.0227284679817955 no 144 0.0251402414359573 62 763417
SGTC_2857 9024691 58.44 µM 1.95690338849078 0.0227653220872834 no 145 0.0251794140538388 50 16478292
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.95572983554224 0.0228303188870441 no 146 0.0252484940653743 47 4174840
SGTC_2477 5967686 25.23 µM 1.95311802990197 0.0229755341662811 no 147 0.0254028055043364 55 776118
SGTC_1400 3771-8998 51.5 µM 1.94844117407607 0.0232375093206108 no 148 0.0256810985910179 21 670767
SGTC_1103 duloxetine 36.1 µM 1.94378654827325 0.0235007313407296 no 149 0.0259605982865053 71 60835 A selective serotonin reuptake inhibitor.
SGTC_1634 st006576 41 µM 1.9369823618049 0.0238900225794732 no 150 0.026373749740695 52 3915356
SGTC_2100 5377183 190 µM 1.93039063271181 0.0242723131455902 no 151 0.0267792273544306 70 2844202
SGTC_2137 5261020 140 µM 1.92599853441724 0.0245298764846552 no 152 0.0270522784220735 58 763655
SGTC_1231 0242-0792 125 µM 1.92271754620536 0.0247237750426591 no 153 0.0272577660208875 50 3707635
SGTC_1979 st071809 45.3 µM 1.92084689690702 0.0248349003344562 no 154 0.0273755060762595 61 4976333
SGTC_2642 cholecalciferol 100 µM 1.90850955202245 0.0255783349790328 no 155 0.0281626948887841 38 9821465 A vitamin D precursor, similar to steriods.
SGTC_1073 triclabendazole 3.09 µM 1.90443298090946 0.0258280440066811 no 156 0.0284269086419825 50 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3127 9126946 49.47 µM 1.90319625143457 0.0259042015818464 no 157 0.0285074710582732 61 27243249
SGTC_2441 5730946 39.09 µM 1.89794549976006 0.0262296372364178 no 158 0.0288516308851237 57 1774275
SGTC_130 0136-0219 337.655 µM 1.89312287132497 0.0265315430214943 no 159 0.0291707656366786 67 234244
SGTC_1119 parthenolide 318.541 nM 1.8780750742232 0.027492284160316 no 160 0.030185447818779 63 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2666 tannic acid 100 µM 1.86606169063604 0.0282799578412714 no 161 0.0310163674858319 73 16134267 A thiamine antagonist.
SGTC_159 3970-0959 50 µM 1.86099634519714 0.0286176583580071 no 162 0.0313723464093648 98 6615653
SGTC_1596 piperlongumine 63 µM 1.85519727738504 0.0290083862897765 no 163 0.0317840301706012 52 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_400 oxethazaine 37.5 µM 1.8460885420511 0.0296310557444625 no 164 0.0324396751279559 64 4621 A local anesthetic.
SGTC_176 1486-1328 72.834 µM 1.83650922844763 0.030297819476775 no 165 0.0331411892519696 86 22310231
SGTC_2032 5185112 25.99 µM 1.83175139732443 0.0306335797242635 no 166 0.0334942336742745 45 5718189
SGTC_2782 7736369 71.43 µM 1.8295551075151 0.0307896082816578 no 167 0.0336582459110393 75 2950836 YOL077C BRX1
SGTC_2382 9035899 200 µM 1.82323417863099 0.0312423341116497 no 168 0.0341339652758946 70 6462679
SGTC_1418 3966-3099 2.4 µM 1.81545451234824 0.0318070836272452 no 169 0.0347270451532948 80 740335
SGTC_831 k061-1017 217 µM 1.81308382346196 0.0319808463200534 no 170 0.0349094468824885 86 1240153
SGTC_366 0181-0206 4.31 µM 1.80619951049382 0.0324898891718075 no 171 0.0354435906855946 75 274874
SGTC_2024 5144227 134 µM 1.80163181978734 0.0328313099528727 no 172 0.0358016757625094 57 3475211
SGTC_18 0111-0177 500 nM 1.80038112942347 0.0329253092840118 no 173 0.0359002392044225 70 721752
SGTC_3028 9087778 49.47 µM 1.79655328739399 0.0332143812787435 no 174 0.0362032829487254 65 17217395
SGTC_992 3909-8734 162 µM 1.79166962354495 0.0335862188111314 no 175 0.0365929515822516 63 4288319
SGTC_3075 9116269 49.47 µM 1.7902517618162 0.0336948129886186 no 176 0.0367067236158712 62 17015205 YNL244C SUI1
SGTC_1733 st037357 54.9 µM 1.78885861531785 0.0338017954822239 no 177 0.0368187940886 72 1272339 YGL099W LSG1
SGTC_1254 0550-0035 264 µM 1.78016719782529 0.0344755534277893 no 178 0.0375243009580632 76 15121435
SGTC_655 k060-0012 42 µM 1.77439574055689 0.0349290231524772 no 179 0.0379988569626234 80 5994525
SGTC_941 3237-0776 460 µM 1.76939048251544 0.03532624532831 no 180 0.0384143664086 53 760008
SGTC_1981 st071826 47 µM 1.76278023348207 0.0358565110354366 no 181 0.0389687812326018 68 11838600
SGTC_290 2043-6722 48.1 µM 1.75796034603353 0.0362472530951425 no 182 0.0393771283439364 57 773758 YLR208W SEC13
SGTC_883 0850-0245 24.6 µM 1.75681691047377 0.0363404597195082 no 183 0.0394745108751499 88 6823229 YPR165W RHO1
SGTC_1999 st074831 12.5 µM 1.75155634219352 0.0367718031395794 no 184 0.0399250625787667 83 17112523
SGTC_2614 arthonioic acid 13.39 µM 1.75138745976494 0.0367857198238291 no 185 0.0399395958028319 55 6710684
SGTC_1765 st044815 90.4 µM 1.75041523106167 0.0368659197073149 no 186 0.0400233448552043 85 645695
SGTC_495 decylubiquinone 155 µM 1.7500387490829 0.036897014366786 no 187 0.0400558138101878 65 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1166 k206-0078 225 µM 1.74922684053971 0.0369641450652767 no 188 0.0401259081304468 76 5404595
SGTC_74 000s-0487 160.283 µM 1.74665513225505 0.0371774398388102 no 189 0.0403485888170072 57 677548
SGTC_3166 9102297 49.47 µM 1.74583645630117 0.0372455506239389 no 190 0.0404196870640623 63 25237072
SGTC_2823 7987624 58.44 µM 1.73859889459553 0.037852133855489 no 191 0.041052670555805 94 2239440
SGTC_421 streptovitacin 30 mM 1.73591522196361 0.0380790925152662 no 192 0.0412894129367164 61 91467 include heat shock
SGTC_2272 7805186 180 µM 1.73478810561047 0.0381747433598074 no 193 0.0413891718716419 68 2956062 YPR165W RHO1
SGTC_2717 st081029 62.2815 µM 1.72888176092701 0.0386791839808401 no 194 0.0419151295115003 57 5292846
SGTC_3179 9107801 49.47 µM 1.72607028453439 0.0389212032584719 no 195 0.042167384502939 47 4818259
SGTC_2625 euphol 100 µM 1.72380891810258 0.0391167612430909 no 196 0.0423711720670807 90 6708538 A triterpene alcohol.
SGTC_1409 3909-8004 61.9 µM 1.72156940532378 0.0393112169177373 no 197 0.042573774685491 76 2119279
SGTC_344 k064-0035 6.43 µM 1.71964261939007 0.0394791475367735 no 198 0.0427487120197018 68 5088750
SGTC_900 1112-0045 141 µM 1.71736981492001 0.0396779853468463 no 199 0.0429558116276422 60 56211 YIL048W NEO1
SGTC_1665 st014639 11.4 µM 1.71358876039726 0.0400105770272291 no 200 0.043302139611027 76 981133 YIL048W NEO1
SGTC_2447 5741742 33.78 µM 1.71192092607157 0.0401580025101026 no 201 0.0434556208545067 84 1776504
SGTC_3213 9129884 49.47 µM 1.71010032488346 0.0403194350312264 no 202 0.04362366136789 73 17190742
SGTC_2247 cerulenin 830 nM 1.70172246142331 0.0410691047436584 no 203 0.044403703876408 68 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2581 avocatin a 64 µM 1.6983220327943 0.0413765900398304 no 204 0.0447234992478771 70 6710728 A skin care supplement.
SGTC_7 0192-1582 4.227 µM 1.69756220742722 0.0414455520036459 no 205 0.0447952104102553 101 252616
SGTC_3281 9140613 49.47 µM 1.69656070308074 0.0415365910796215 no 206 0.0448898722773952 63 16013766
SGTC_1872 amphotericin b 148 nM 1.69627478200307 0.0415626116814563 no 207 0.0449169269766536 77 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2532 xanthone 78.9 µM 1.69023050806314 0.0421157754306785 no 208 0.0454919319531955 53 7020 An insecticide.
SGTC_255 tunicamycin 200.472 nM 1.68973750565289 0.0421611559234146 no 209 0.0455390922597927 86 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1836 st055642 81 µM 1.6888162340407 0.0422460643267926 no 210 0.0456273258969271 87 8571
SGTC_3001 9076041 71.4286 µM 1.68841840649754 0.0422827725929405 no 211 0.0456654697971097 63 16004211
SGTC_135 0933-0004 26.348 µM 1.68692939715638 0.0424203952863048 no 212 0.0458084643223064 83 21230617 YGL099W LSG1
SGTC_2641 levomentholum 100 µM 1.68567392726177 0.0425367142672466 no 213 0.0459293107007576 59 16666
SGTC_3197 9113331 49.47 µM 1.68452774142617 0.042643133204897 no 214 0.0460398613965148 90 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1937 st074714 47.2 µM 1.68447836265775 0.042647722665328 no 215 0.0460446288235013 54 17250970
SGTC_1781 st038725 66.3 µM 1.68291023973844 0.0427936781196679 no 216 0.0461962345119268 82 4270275 YIL048W NEO1
SGTC_2323 6148992 148.28 µM 1.67787370511036 0.0432651940306364 no 217 0.0466858783935357 73 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1492 4158-0558 28.5 µM 1.67539739914966 0.0434985573151388 no 218 0.046928143289501 56 3967268
SGTC_296 1222-0039 74.9 µM 1.67314758093814 0.043711456619889 no 219 0.0471491233246378 64 5984176
SGTC_2091 4-phenylthiadiazole 200 µM 1.66828700594815 0.0441742811406624 no 220 0.0476293830794568 74 270010
SGTC_1966 st070145 16.1 µM 1.66622461807821 0.0443718519793894 no 221 0.0478343422029183 90 3748532
SGTC_612 0302-0167 22.4 µM 1.64930677377328 0.0460195397360243 no 222 0.0495424013155856 87 235821
SGTC_3316 9136639 10.545 µM 1.64555907207083 0.0463911112691359 no 223 0.0499272856672395 71 4903665
SGTC_1759 st043059 70 µM 1.64371573558939 0.046574753265523 no 224 0.0501174670241203 90 669426
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.63959810113768 0.0469870789313963 no 225 0.0505443790914453 100 1273210
SGTC_3116 9124943 49.47 µM 1.63885314361408 0.0470619881602109 no 226 0.0506219240894068 81 41905195 YPL160W CDC60
SGTC_477 mead ethanolamide 10 µM 1.63639744316917 0.0473095994746539 no 227 0.0508782169818917 29 16061185
SGTC_937 3122-0005 46.7 µM 1.63098258209901 0.0478592760082622 no 228 0.0514469974161787 78 759535
SGTC_1096 rimcazole 32.2 µM 1.62582057821028 0.0483880333534273 no 229 0.0519939147043659 60 18528119 A dopamine reuptake inhibitor.
SGTC_2384 9036245 200 µM 1.61755426400294 0.0492444945087458 no 230 0.052879346178646 58 6462766
SGTC_26 0302-0163 425.158 µM 1.61200435073451 0.0498262744684118 no 231 0.0534804964888406 101 3100915
SGTC_1328 1441-0025 69.2 µM 1.60435480907308 0.0506371233486722 no 232 0.0543179330936984 64 4562601
SGTC_1866 st057638 64 µM 1.60396158342015 0.0506790874991929 no 233 0.0543612604120646 47 688802
SGTC_2289 7946404 165.07 µM 1.60356517038158 0.0507214198303041 no 234 0.0544049665997586 110 1246120 YPR165W RHO1
SGTC_3350 9150499 3.57 µM 1.60214671636316 0.0508731250239537 no 235 0.0545615847766356 100 4910996 YPR165W RHO1
SGTC_519 k048-0011 62.8 µM 1.6001840129393 0.0510836337757434 no 236 0.0547788838352503 73 6836379
SGTC_79 0052-0007 94.094 µM 1.59706756104516 0.0514193108547045 no 237 0.0551253240672623 78 2801472
SGTC_1655 st012546 55.1 µM 1.59454541704788 0.0516922566902658 no 238 0.0554069634063066 65 720985 YLR208W SEC13
SGTC_638 3970-0837 4.09 µM 1.58803647047198 0.0524019765744691 no 239 0.0561390462218163 70 4118451 YLR208W SEC13
SGTC_2598 perillyl alcohol 100 µM 1.57961997800359 0.0533311349632791 no 240 0.057096960645876 90 10819 An apoptosis inducer.
SGTC_956 1185-0240 191 µM 1.57850213789672 0.0534555178335695 no 241 0.057225148687178 76 1416193
SGTC_1040 k898-0338 155 µM 1.57114813273798 0.0542795430918377 no 242 0.0580741222629663 78 20969351
SGTC_274 sirtinol 40.1 µM 1.56956237760199 0.0544585393704687 no 243 0.0582584784722269 94 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2566 crystal violet carbinol 226 nM 1.56610573913002 0.0548503344627322 no 244 0.0586619323724114 131 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3283 9109332 35.8195 µM 1.56202783728322 0.0553154078678187 no 245 0.0591407155755116 62 17027281
SGTC_3292 9120825 59.784 µM 1.5619066737899 0.0553292737203515 no 246 0.0591549880301706 101 24824900
SGTC_3265 9137266 49.47 µM 1.5546987273525 0.0561590951735339 no 247 0.0600089189272136 55 17224265
SGTC_3129 9127257 49.47 µM 1.5510249625619 0.0565858000377966 no 248 0.0604478509473582 85 837894
SGTC_358 0075-0058 9.45 µM 1.54413776843788 0.0573926217690102 no 249 0.0612774804548498 93 1069125
SGTC_1071 trifluoperazine 6.31 µM 1.53909943755676 0.0579885644743913 no 250 0.061890011174742 94 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_205 1486-1330 71.903 µM 1.53641968933266 0.0583075052116148 no 251 0.06221774040846 90 4118834
SGTC_1522 st012842 45.6 µM 1.53477821858909 0.0585035507724121 no 252 0.0624191574232631 98 3491067 YOR116C RPO31
SGTC_2453 5731132 22.18 µM 1.53471359045361 0.0585112800733317 no 253 0.0624270980231201 114 1362040
SGTC_1562 morin hydrate 59.1 µM 1.53021316869925 0.059051489607906 no 254 0.0629819864131302 91 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2114 5491910 81.25 µM 1.53006594342512 0.059069227706227 no 255 0.0630002035334394 96 2849228
SGTC_1612 st002233 45.4 µM 1.52094907983401 0.0601758174258778 no 256 0.0641363080493269 89 1035021
SGTC_1357 1503-1303 39.5 µM 1.52007299933983 0.0602830036864288 no 257 0.064246314892337 94 292895
SGTC_44 0929-0055 61.211 µM 1.51168978973697 0.0613162397376951 no 258 0.0653063986427889 102 1379590
SGTC_227 fluconazole 33.516 µM 1.50495793695021 0.0621559187934917 no 259 0.0661674456710061 153 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.50201375848837 0.0625259605699675 no 260 0.0665467778078185 103 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2358 9037157 4 µM 1.50106048997606 0.0626461403642857 no 261 0.0666699583701456 109 2388925
SGTC_3181 9108277 49.47 µM 1.48876891686864 0.0642119306486711 no 262 0.0682741150234473 110 17097298
SGTC_653 0203-0016 55.2 µM 1.47939751171905 0.0654260356876553 no 263 0.06951705238863 101 295302
SGTC_3157 9099274 49.47 µM 1.46694336704334 0.0670669845319184 no 264 0.071195730979815 89 17217662
SGTC_479 n-linoleoylglycine 10 µM 1.4650897745355 0.0673139101936011 no 265 0.0714482130582142 110 6433346 An anti-infammatory.
SGTC_3240 9133527 49.47 µM 1.46423888456929 0.0674274962863152 no 266 0.0715643445992423 90 17617455
SGTC_3195 9113082 49.47 µM 1.46334241807164 0.0675473266225358 no 267 0.0716868531576132 84 17018038
SGTC_1523 st012844 44.7 µM 1.46201727026343 0.0677247599472326 no 268 0.071868238670641 79 4274103
SGTC_403 arphamenine a 50 µM 1.45904891882982 0.0681235196577338 no 269 0.0722758220108025 112 5487158 An arginine aminopeptidase inhibitor.
SGTC_2916 7875993 68.79 µM 1.45511309705189 0.0686550382765406 no 270 0.072818976960065 99 1299250
SGTC_1868 st057644 42.7 µM 1.45230456195739 0.0690362721742649 no 271 0.0732084697912244 102 688665
SGTC_2634 4'-methoxyflavone 100 µM 1.4518996485921 0.0690913699034877 no 272 0.0732647551443497 88 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_917 harmaline 728.087 nM 1.44733174918788 0.0697152868634384 no 273 0.0739020155144683 102 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2063 5246145 200 µM 1.44689053682055 0.0697757798165148 no 274 0.073963791979283 114 711240
SGTC_3260 9137109 49.47 µM 1.44651838599307 0.0698268354080609 no 275 0.0740159294446925 81 17478346
SGTC_22 0964-0034 14.468 µM 1.44563179525752 0.069948583150167 no 276 0.0741402518695642 134 138402
SGTC_2278 7948257 134.34 µM 1.44433796693459 0.0701265462881067 no 277 0.0743219654446284 80 1247028
SGTC_2927 9011802 47.9 µM 1.44330193551274 0.0702693009895377 no 278 0.0744677174001158 86 43912568
SGTC_602 3130-1533 38.1 µM 1.43509262635322 0.0714083740767504 no 279 0.0756303522387436 126 720941
SGTC_697 0508-1955 564 µM 1.42892143238689 0.0722739416096758 no 280 0.0765134082907358 95 6243113
SGTC_1618 st003135 44.5 µM 1.42885780259776 0.0722829079743322 no 281 0.076522553959797 111 1270615
SGTC_2213 7173844 200 µM 1.42745381987362 0.0724809665875558 no 282 0.0767245635800669 107 892728
SGTC_3117 9124945 49.47 µM 1.42486595074294 0.0728471240432252 no 283 0.0770979768739297 84 17592065
SGTC_869 0564-0080 44.1 µM 1.42362534770783 0.0730231582862541 no 284 0.0772774771161068 84 6843321
SGTC_788 1182-0090 188 µM 1.41961481480205 0.0735944569512909 no 285 0.0778599250100723 114 5715185
SGTC_453 enantio-paf c16 10 µM 1.41796466140466 0.0738305104614308 no 286 0.0781005411665203 136 13871343 A lipid and platelet activating factor
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.41463592306508 0.0743084449982673 no 287 0.0785876352559309 102 803109
SGTC_3120 9124077 49.47 µM 1.41454162211109 0.0743220188990383 no 288 0.0786014677722484 97 18774327 YGL155W CDC43
SGTC_2195 6536160 144.242 µM 1.41369091768895 0.07444455688802 no 289 0.0787263366018008 92 3834386
SGTC_694 1315-0438 43.2 µM 1.41082695741537 0.0748582240696205 no 290 0.0791478218634278 88 6793154
SGTC_3009 9080819 71.4286 µM 1.40515467189491 0.075682695447743 no 291 0.0799876448356908 115 17027216
SGTC_2376 9072922 81.32 µM 1.40512942529983 0.0756863804618257 no 292 0.0799913977799837 111 17087968
SGTC_2038 4100038 30.985 µM 1.39874553571992 0.0766225722663807 no 293 0.0809446519746768 129 3596803
SGTC_2986 9022445 71.43 µM 1.39583456276672 0.0770523763758081 no 294 0.0813821598536309 119 6459286
SGTC_145 3737-0113 38.366 µM 1.39462778417904 0.0772310930931761 no 295 0.0815640560681626 161 6849351
SGTC_2851 9015922 71.43 µM 1.38996491473512 0.0779245964600274 no 296 0.0822697658314156 124 2996893
SGTC_658 3253-0951 102 µM 1.38581388579621 0.0785459411864368 no 297 0.082901870602659 119 1184878
SGTC_594 1487-1584 10.8 µM 1.38524361742217 0.078631594112356 no 298 0.0829889938367467 124 5013332
SGTC_1097 itavastatin 7.23 µM 1.38341010281246 0.0789074632676117 no 299 0.0832695772693074 129 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1205 4161-2785 76 µM 1.38292252264435 0.0789809474586336 no 300 0.0833443117575694 100 3498106
SGTC_192 3455-0609 60.9 µM 1.38027753438614 0.0793804825100567 no 301 0.0837506046532174 107 3769639
SGTC_2652 actinonin 100 µM 1.37975934487699 0.0794589358119791 no 302 0.0838303770111947 115 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_621 3584-0052 32.1 µM 1.37833186967613 0.079675357400472 no 303 0.0840504239141407 119 2273927
SGTC_282 k297-0036 65.7 µM 1.3748380753797 0.0802069377296564 no 304 0.0845908254479055 117 5061378
SGTC_1226 3909-7979 35.4 µM 1.37450439972707 0.0802578463341316 no 305 0.0846425726511177 133 6615510
SGTC_446 go6976 132 µM 1.36772985318194 0.0812967211697444 no 306 0.0856983259042811 101 3501 A protein kinase C inhibitor.
SGTC_728 3030-5151 22.5 µM 1.36592323022281 0.0815754723121169 no 307 0.0859815302765286 99 3125388
SGTC_1958 st076513 41.9 µM 1.36363774281148 0.0819291411698386 no 308 0.0863408035678517 120 732122 YGL099W LSG1
SGTC_3320 9137005 35.139 µM 1.36230796953537 0.0821354486171138 no 309 0.0865503567928261 133 4908713
SGTC_1483 3453-0561 55.9 µM 1.36077004685348 0.0823745371093214 no 310 0.0867931852344526 129 4546991
SGTC_199 4063-0024 41.6 µM 1.35838355724997 0.082746582486154 no 311 0.0871710044849073 75 306215
SGTC_491 tetrandrine 80.3 µM 1.35569922853121 0.0831665693623247 no 312 0.087597442495749 110 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3136 9095672 49.47 µM 1.35549247643724 0.0831989839120571 no 313 0.08763035201229 121 17217380
SGTC_1345 1488-0192 31.4 µM 1.35356741940666 0.0835012500702898 no 314 0.0879372135959435 111 658348
SGTC_1319 1306-0155 43.7 µM 1.34935512438781 0.0841655283113995 no 315 0.088611463760677 119 3122360
SGTC_435 c-PAF 6.7 µM 1.34643046277729 0.0846290749399781 no 316 0.0890818660816781 119 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2620 irigenin 100 µM 1.34345378928874 0.0851028287922509 no 317 0.0895625398392122 144 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_311 1315-0136 58 µM 1.343260743785 0.0851336215289564 no 318 0.0895937793300692 106 6759207
SGTC_1289 0976-0073 69.1 µM 1.33957995690176 0.0857223431448307 no 319 0.0901909718110812 114 3391136
SGTC_2791 5663188 71.43 µM 1.33751274202641 0.0860543165073954 no 320 0.0905276629311465 139 54690634
SGTC_817 1391-0715 46 µM 1.33414423108692 0.0865973238520139 no 321 0.0910782962105215 145 1353946
SGTC_1511 0906-3109 28.5 µM 1.32991256734412 0.0872830968543196 no 322 0.0917735401186049 126 2882180
SGTC_3339 9145883 14.936 µM 1.32980213136483 0.0873010479680803 no 323 0.0917917367622601 103 2030670
SGTC_1529 apigenin 74 µM 1.329594950502 0.0873347321750316 no 324 0.0918258813643415 126 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_206 4546-0025 72.014 µM 1.32876299077086 0.0874700928785246 no 325 0.0919630878739771 119 6620745 YIL048W NEO1
SGTC_2667 digitoxin 100 µM 1.32332629554034 0.0883585059075061 no 326 0.0928634453354182 78 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2401 5128683 200 µM 1.32266074773357 0.0884677237157943 no 327 0.0929741112653098 117 708373
SGTC_2118 5526350 200 µM 1.32244364212754 0.0885033729548374 no 328 0.0930102322219394 133 743594
SGTC_2921 7974240 10.71 µM 1.32051883360406 0.0888198991038338 no 329 0.0933309261023188 123 2979074 YDR527W RBA50
SGTC_2587 piperic acid 92.2 µM 1.31911694772582 0.0890509629421093 no 330 0.0935650090571388 97 5370536
SGTC_949 1165-0505 146 µM 1.31868982534061 0.0891214516253653 no 331 0.0936364148493513 106 6244267
SGTC_1084 voriconazole 435 nM 1.3172338104707 0.0893620521046774 no 332 0.0938801319908601 125 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_84 0443-0269 128.823 µM 1.31523792182739 0.089692649210092 no 333 0.0942149770202971 119 6150058
SGTC_2608 thymoquinone 42.66 µM 1.31516067645722 0.0897054623126186 no 334 0.0942279539591731 118 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1574 spiramycin 23.7 µM 1.31273545523454 0.0901084390981968 no 335 0.0946360530073245 132 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1734 st037168 69.4 µM 1.31150971687516 0.0903126197320109 no 336 0.09484280652653 123 708907
SGTC_1610 st001799 48.1 µM 1.30819122577499 0.0908671303375072 no 337 0.095404228687307 107 621897
SGTC_98 0074-0023 107.663 µM 1.30539280612717 0.0913366984220981 no 338 0.0958795633631102 100 3563821
SGTC_1383 3049-0032 20.7 µM 1.30224522069886 0.091867002572905 no 339 0.0964162855689272 139 712864
SGTC_3162 9099653 49.47 µM 1.29987224861133 0.0922683053348503 no 340 0.0968223789791843 96 25237511
SGTC_2769 toremifene 3.73 µM 1.29932351690945 0.092361287970691 no 341 0.096916463521626 133 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_950 1165-0508 94.1 µM 1.2945895575614 0.0931663389742844 no 342 0.0977309282942346 116 6148369
SGTC_2295 7971645 200 µM 1.29398881188251 0.0932688706534486 no 343 0.0978346426884418 109 2978226 YKL099C UTP11
SGTC_185 k048-0037 25.491 µM 1.29352099411913 0.0933487727140754 no 344 0.0979154638978696 103 6827589
SGTC_2969 9091408 28.7 µM 1.28972073528347 0.0939997217285777 no 345 0.0985738187651408 129 4286311
SGTC_1415 3966-0071 78.1 µM 1.28834140804033 0.0942368142891429 no 346 0.0988135724592215 117 2893185
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.28662207849171 0.0945329670775064 no 347 0.0991130222094704 136 688801
SGTC_121 0557-0495 61.343 µM 1.28616922914085 0.0946110839632166 no 348 0.0991920037447631 143 3104427
SGTC_1480 1070-0044 41.2 µM 1.28275218242988 0.0952020619978346 no 349 0.0997894558086514 124 3124987
SGTC_1833 st055984 71 µM 1.28188658444044 0.0953521977233947 no 350 0.0999412173636033 119 676288
SGTC_2354 9060492 162 µM 1.28116159765257 0.0954780788735643 no 351 0.100068455817275 140 6471895
SGTC_2740 felodipine 17.08 µM 1.27907139386026 0.0958416904574122 no 352 0.100435958019173 82 3333 L-type calcium channel blocker
SGTC_168 3970-0862 530.542 µM 1.27783780156975 0.096056763412344 no 353 0.100653311328043 186 3135186
SGTC_3144 9087057 49.47 µM 1.27622211417571 0.0963389899427968 no 354 0.10093850672675 116 17249618
SGTC_2488 5268135 45.7 µM 1.27474046730499 0.0965983376566012 no 355 0.101200559199458 141 1270356 YLR208W SEC13
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.27427760168423 0.0966794627731475 no 356 0.101282525779921 130 2333 A French combination drug.
SGTC_2140 5586273 200 µM 1.27271005979085 0.0969545729850444 no 357 0.101560473283659 118 854421
SGTC_676 falcarinol 140 µM 1.2657392041359 0.0981849496385336 no 358 0.102803233765483 137 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_259 usnic acid 108.925 µM 1.26473044654403 0.0983639415034009 no 359 0.102983985897475 150 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_659 k018-0002 107 µM 1.26357558790098 0.0985691504825395 no 360 0.103191200151805 128 6797879 YHR007C ERG11
SGTC_2755 lomerizine 42.69 µM 1.26338926458586 0.0986022879585359 no 361 0.10322466016082 112 3949 A calcium channel blocker.
SGTC_3235 9132602 49.47 µM 1.2615225579021 0.0989347306963317 no 362 0.103560318942969 147 4912240
SGTC_1399 3562-5772 25 µM 1.26031824410392 0.0991496422761467 no 363 0.103777290570273 125 23847490
SGTC_2999 9069765 71.4286 µM 1.25965107659622 0.0992688461630688 no 364 0.103897630676907 116 2097066
SGTC_2473 5854593 8.94 µM 1.25779624264889 0.0996008028780514 no 365 0.104232727454919 141 2872951
SGTC_1428 4049-0204 61.7 µM 1.25693203957743 0.0997557446638864 no 366 0.104389122785305 149 X1428
SGTC_2172 5754775 163.918 µM 1.25689060962392 0.0997631770041791 no 367 0.104396624657098 161 2263357
SGTC_2960 9079389 5.97 µM 1.25624225453383 0.0998795415873171 no 368 0.10451407556047 108 16457355
SGTC_1010 4112-3296 15.2 µM 1.25494951600355 0.100111853762857 no 369 0.104748543563814 111 704384
SGTC_637 1181-0519 7.26 µM 1.25426268709066 0.100235441030189 no 370 0.104873270703543 138 6252091 YGR060W ERG25
SGTC_1997 st073024 93.8 µM 1.24796410090471 0.101373998601287 no 371 0.10602210208099 120 686268
SGTC_1638 st008370 60.6 µM 1.2474101371095 0.101474584231632 no 372 0.106123575738557 145 24207134
SGTC_979 1426-2828 121 µM 1.24724305905004 0.101504935589622 no 373 0.106154194433598 139 747872
SGTC_3043 9092303 49.47 µM 1.24552256449267 0.101817864861054 no 374 0.106469863226486 112 25236084
SGTC_3007 9078383 71.4286 µM 1.24417217807516 0.102063969084635 no 375 0.106718100512044 140 6496995
SGTC_2235 salicylic acid 500 µM 1.24339016488514 0.102206686596194 no 376 0.106862046376398 121 338 A COX inhibitor and kinase inhibitor.
SGTC_3270 9137563 49.47 µM 1.2430170370712 0.102274833605785 no 377 0.106930777690098 117 17015724
SGTC_1138 3761-0006 1.03 µM 1.24295831925016 0.102285560671548 no 378 0.106941596600422 115 12061087
SGTC_3106 9121286 49.47 µM 1.24266745400131 0.102338710450241 no 379 0.106995200918751 115 15943471
SGTC_3242 9133940 49.47 µM 1.24196290343615 0.102467536149058 no 380 0.107125124712897 114 17248444
SGTC_1284 0929-0043 16 µM 1.24029396084001 0.102773169430146 no 381 0.107433342663914 136 1239883
SGTC_65 0798-0905 34.986 µM 1.24021963007259 0.102786797008764 no 382 0.107447084816919 142 3602145
SGTC_3033 9090887 49.47 µM 1.23925783191268 0.102963248616082 no 383 0.10762501478633 143 19325384
SGTC_1835 st008666 49.2 µM 1.23905021710996 0.103001366512944 no 384 0.107663450788325 105 690455
SGTC_1229 0139-0193 12.2 µM 1.23800354005402 0.103193691620214 no 385 0.107857374102454 145 3090752
SGTC_974 1326-0144 138 µM 1.23747613774581 0.103290699632173 no 386 0.107955183940848 131 5411856
SGTC_3309 9129340 25.759 µM 1.23514600464721 0.103720086340979 no 387 0.108388085225832 128 17158987
SGTC_3149 9097855 49.47 µM 1.23447362080564 0.103844230706596 no 388 0.108513235249894 115 25236625 YMR079W SEC14
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.23384490215723 0.103960410502495 no 389 0.108630351940206 123 16486 A toxic proline analog.
SGTC_2082 5219693 150 µM 1.23237013787525 0.104233299364486 no 390 0.108905425316011 132 2834649
SGTC_3 0833-0587 95.581 µM 1.22917599595381 0.104826119370319 no 391 0.109502913361509 148 5382644
SGTC_765 1319-0117 244 µM 1.2291397023336 0.104832869320215 no 392 0.109509715852939 131 3487746 YGL099W LSG1
SGTC_2656 pseudo-anisatin 100 µM 1.22860811654746 0.104931770623408 no 393 0.109609385433307 135 6708809 A neurotoxin.
SGTC_1144 3486-0183 12.5 µM 1.22790681134448 0.10506235146631 no 394 0.109740976147152 147 6744069
SGTC_1336 1486-0901 104 µM 1.22524378754134 0.105559269405898 no 395 0.110241690436415 130 5006114
SGTC_1841 st054148 70 µM 1.22054280496932 0.106440612909574 no 396 0.111129586543601 150 675442
SGTC_2669 eugenol 100 µM 1.21945398142681 0.106645501962248 no 397 0.111335966005996 92 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2981 9013952 38.96 µM 1.21755362907058 0.107003781909955 no 398 0.111696822507534 129 2996344
SGTC_15 0266-0086 27.098 µM 1.21640784627536 0.107220219378941 no 399 0.111914798249567 159 1712902 YIL048W NEO1
SGTC_490 phenamil 164 µM 1.21543003072418 0.107405177464642 no 400 0.112101060030322 139 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1771 st048882 4.1505 µM 1.21176981477499 0.10809956480734 no 401 0.112800253001514 148 4580403
SGTC_737 1950-0117 57.9 µM 1.21128243617481 0.108192269712577 no 402 0.112893588912258 141 5393513
SGTC_1649 st011737 51.3 µM 1.21103717828193 0.108238942167721 no 403 0.11294057810857 130 1761035
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.21037437358104 0.108365146067452 no 404 0.113067635338634 160 442882
SGTC_2412 st077135 33.4 µM 1.20883009809488 0.108659600508768 no 405 0.113364062897191 144 13258915
SGTC_1249 0481-0015 10.2 µM 1.20833660138656 0.108753819120254 no 406 0.113458907595911 153 4227577
SGTC_2881 9058953 51.95 µM 1.20739858483301 0.108933067586307 no 407 0.113639340145047 133 17122249
SGTC_1748 st037455 53.6035 µM 1.20440367281691 0.109506795845119 no 408 0.114216796580717 141 580690
SGTC_1664 st014217 9.02 µM 1.2013718355651 0.110089804827318 no 409 0.114803498115483 146 3982782
SGTC_2025 5147754 141 µM 1.19989983088388 0.110373666489624 no 410 0.115089122836273 123 315777 YLR208W SEC13
SGTC_3073 9114972 49.47 µM 1.199441948949 0.110462071451281 no 411 0.115178072240421 117 41905075
SGTC_808 0711-0032 135 µM 1.19823562318121 0.110695224258422 no 412 0.115412650377414 157 4252555
SGTC_2908 7930301 100 µM 1.196891847914 0.110955357629801 no 413 0.115674356013126 147 2223178
SGTC_1194 1488-0194 225 µM 1.19564182843629 0.11119773423802 no 414 0.115918180520182 138 1391452
SGTC_1502 4534-4282 27.7 µM 1.1951183235671 0.11129935346865 no 415 0.116020401919255 136 3278949
SGTC_795 0685-0265 78 µM 1.19170369295576 0.111963809712954 no 416 0.116688724762603 169 302754
SGTC_1672 st016598 6.51 µM 1.19117876918308 0.112066206136746 no 417 0.116791706166293 153 4665860 YNL267W PIK1
SGTC_1344 1488-0097 29.1 µM 1.1900918826101 0.112278436934187 no 418 0.117005140193894 153 747966
SGTC_3047 9092122 49.47 µM 1.18757155419468 0.112771673448738 no 419 0.117501125174108 140 17173831
SGTC_3126 9127922 49.47 µM 1.18542790283556 0.113192408971376 no 420 0.117924152441381 195 45595682
SGTC_414 piperonyl butoxide 100 µM 1.18478982936395 0.113317859987977 no 421 0.118050277431127 149 5794 A potent inhibitor of cytochrome P450.
SGTC_2018 5133068 143 µM 1.17922434756887 0.114416290541553 no 422 0.119154426712856 142 785362
SGTC_2841 9004761 38.96 µM 1.1783377973123 0.114591961956841 no 423 0.119330982497383 122 2991039
SGTC_2944 9067346 25.62 µM 1.17788197040055 0.114682359505722 no 424 0.119421831896327 162 6473075
SGTC_323 4013-0906 34.3 µM 1.17779754614188 0.114699107714046 no 425 0.119438663579341 137 2910086
SGTC_2996 9066192 71.4286 µM 1.17416556810743 0.115421273492727 no 426 0.120164357303192 137 6472854
SGTC_2055 5235184 200 µM 1.17224519514362 0.115804414861511 no 427 0.12054931397571 142 2836034
SGTC_257 daunorubicin 18.5 µM 1.17046098761109 0.116161197938281 no 428 0.120907752483907 144 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_552 k242-0005 476 µM 1.16789479748682 0.116675718749563 no 429 0.121424601467951 153 4088318
SGTC_1705 st027868 56.3335 µM 1.16752518035552 0.116749959870068 no 430 0.121499172777995 123 292948
SGTC_56 0957-0365 83.25 µM 1.16614497460531 0.117027483348777 no 431 0.121777917756383 153 6752360
SGTC_3219 9131112 49.47 µM 1.16517659637974 0.117222477867879 no 432 0.121973758478628 156 17612988 YMR079W SEC14
SGTC_1520 flindersine 88 µM 1.1552222054677 0.119240263540814 no 433 0.123999721841431 165 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2218 6965428 192.983 µM 1.1549794747909 0.119289770097788 no 434 0.124049415880862 138 675684
SGTC_1236 0330-0013 258 µM 1.15450340963975 0.119386908914367 no 435 0.124146920747188 128 4617066
SGTC_1106 tegaserod maleate 11.7 µM 1.1529287055088 0.119708617370252 no 436 0.124469824341968 164 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_104 0074-0074 590.992 µM 1.15134855627662 0.12003205228769 no 437 0.124794434309187 143 3943124
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.15081927319928 0.12014052686687 no 438 0.124903297045393 184 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_539 4859-0462 2.54 µM 1.15058944495731 0.120187650805973 no 439 0.124950588681927 158 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3185 9108267 49.47 µM 1.14829228778906 0.120659375204459 no 440 0.125423960899518 144 4910486
SGTC_1363 1636-0063 10.4 µM 1.1469968791704 0.120925963201583 no 441 0.125691455372396 175 6072185
SGTC_1066 ketoconazole 628 nM 1.146026635295 0.121125905360597 no 442 0.125892065694875 162 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3054 9094397 49.47 µM 1.14358122291699 0.121630872908699 no 443 0.126398676251523 162 2598354
SGTC_3315 9136395 68.55 µM 1.14348278436408 0.121651230993735 no 444 0.12641909924241 196 16876844
SGTC_1807 st050092 58.9 µM 1.14035926057985 0.122298451022278 no 445 0.127068329109841 158 5008496
SGTC_41 0478-0632 82.643 µM 1.13587035379487 0.123232816476494 no 446 0.128005413676673 165 3750424
SGTC_1271 0832-2808 169 µM 1.13553779338905 0.123302237382229 no 447 0.128075028053664 176 3663794
SGTC_2988 9073640 71.4286 µM 1.13501369193783 0.123411697470368 no 448 0.128184790805926 153 9102229
SGTC_1956 st077085 54 µM 1.13490839670955 0.123433696889503 no 449 0.128206850701574 175 24208685
SGTC_1855 st056195 39.6 µM 1.13348436273016 0.123731491313996 no 450 0.128505452148482 146 4028379
SGTC_1200 1643-0193 18.4 µM 1.12885711443134 0.124702614271081 no 451 0.129479057216179 169 5403974
SGTC_3060 1327-0027 12.5 µM 1.12727556065293 0.125035754049433 no 452 0.129812996005644 154 16000455 YPR107C YTH1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.12551892505005 0.125406501292963 no 453 0.130184601129821 168 689007
SGTC_1253 0550-0034 176 µM 1.12549036313155 0.125412535769985 no 454 0.130190649297871 155 5969915
SGTC_1521 st012942 49.4 µM 1.1249933204779 0.125517581915255 no 455 0.130295932376865 144 24207259
SGTC_1292 0kpi-0043 232 µM 1.12450493471494 0.1256208582867 no 456 0.130399439119917 154 3333905
SGTC_3319 9138450 16.7555 µM 1.12394207178955 0.125739957477803 no 457 0.13051880081698 139 2029690
SGTC_1742 st038235 28.8875 µM 1.12244550662003 0.126057006811802 no 458 0.130836532486951 175 564103 YBR002C RER2
SGTC_2814 7977482 42.97 µM 1.12242713156962 0.126060903051341 no 459 0.130840436963039 167 6456762
SGTC_2345 9052315 157.45 µM 1.12221890376239 0.126105061472577 no 460 0.130884688481959 152 6469265
SGTC_837 0091-0265 12.5 µM 1.11975239582318 0.126628948944717 no 461 0.131409645168733 176 759367
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.1187513031774 0.126842013366008 no 462 0.131623125873823 120 6708630 An antioxidant.
SGTC_148 3253-0744 288.01 µM 1.1179642792358 0.127009692287808 no 463 0.13179112488071 149 6893655
SGTC_3275 9138069 49.47 µM 1.11776365959725 0.127052459850509 no 464 0.13183397302384 183 17617007
SGTC_711 k292-0785 179 µM 1.1166153183986 0.127297453042889 no 465 0.132079419535248 157 4146315
SGTC_1274 0865-0114 173 µM 1.11656244093719 0.127308742109471 no 466 0.132090729150729 157 870624
SGTC_2524 avocatin b 10.57 µM 1.11415265932679 0.127823957289517 no 467 0.13260685039005 117 6710748
SGTC_1126 isoteolin 1.0172 µM 1.10689622087781 0.129384139584346 no 468 0.134169399994921 151 133323
SGTC_763 3453-1109 128 µM 1.10506341987486 0.129780282693309 no 469 0.134566054840073 151 1560353
SGTC_1021 4476-0760 85.3 µM 1.10461934120095 0.129876392493811 no 470 0.134662283378485 137 746768
SGTC_2856 9022925 19.48 µM 1.10218366909384 0.130404409526623 no 471 0.135190915145331 141 4944862
SGTC_841 0251-0215 91.2 µM 1.10071618562032 0.130723253687209 no 472 0.135510099804658 166 3888614
SGTC_669 0108-0021 26.2 µM 1.10049384034875 0.130771610226828 no 473 0.13555850597156 160 17201
SGTC_3289 9119912 71.43 µM 1.1004616661699 0.130778608619933 no 474 0.135565511503093 151 17014829
SGTC_1445 4239-0156 97.7 µM 1.09966101666521 0.130952845938977 no 475 0.135739922972471 167 4008346
SGTC_2327 6189656 200 µM 1.09965046839427 0.130955142523407 no 476 0.135742221806488 156 5349088
SGTC_3039 9090270 49.47 µM 1.0993707236404 0.131016059102099 no 477 0.135803197620029 139 17173750
SGTC_1275 0867-0008 21.1 µM 1.0965206107922 0.131637809072413 no 478 0.136425504321632 148 3422836
SGTC_1697 st025554 27.742 µM 1.09560068110519 0.131838925028918 no 479 0.136626781759462 155 1269519
SGTC_542 3381-0244 89.3 µM 1.09515479123285 0.13193648215504 no 480 0.136724413951405 170 1112843
SGTC_1950 st077106 7.18 µM 1.09251781759548 0.132514448737717 no 481 0.137302781626428 145 13831864
SGTC_2455 5377712 9.75 µM 1.0914072654512 0.132758378603236 no 482 0.13754685843831 153 2243908
SGTC_559 1550-0661 158 µM 1.09123961394576 0.132795229665142 no 483 0.13758373055037 150 5830875
SGTC_2385 9074692 200 µM 1.09116398660695 0.132811855428411 no 484 0.137600365711981 144 17046906
SGTC_664 1222-0054 14.9 µM 1.09009265936714 0.133047527851753 no 485 0.137836164765982 165 6813991
SGTC_1043 0916-0009 19.3 µM 1.09002869033097 0.133061608972756 no 486 0.137850253063449 172 3101130
SGTC_390 dec-rvkr-cmk 16.7 µM 1.08954080831432 0.133169037266655 no 487 0.137957734664102 151 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1120 ficusin 1.78878 µM 1.08734043949598 0.133654285026006 no 488 0.138443191451882 152 6199 A DNA cross-linker.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.08700941564989 0.133727390850304 no 489 0.138516324270521 159 23847180
SGTC_1489 4065-0444 182 µM 1.08535335198923 0.134093541299889 no 490 0.138882592255437 155 2877968
SGTC_2115 tiliquinol 12.7705 µM 1.08224815390845 0.134781945873309 no 491 0.139571138365275 171 71208 A bioactive hydroxyquinoline.
SGTC_221 trifluoperazine 10.304 µM 1.08223490132825 0.134784889081394 no 492 0.139574081956588 206 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2432 5630864 12.22 µM 1.07785459141498 0.135760109887477 no 493 0.14054932628236 161 5714970
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.07677667329002 0.136000833882926 no 494 0.140790024463069 142 688664
SGTC_2254 7938975 95.19 µM 1.07656146704922 0.136048929375872 no 495 0.140838113303939 159 2969277
SGTC_1632 st005650 90 µM 1.07519094633946 0.13635549416178 no 496 0.141144624014586 156 2759605
SGTC_2185 6113692 200 µM 1.07331230537304 0.136776485164726 no 497 0.141565507953371 167 874150
SGTC_378 3970-0959 8.33 µM 1.07290286609442 0.136868355600585 no 498 0.141657349992291 177 6615653
SGTC_2834 9001755 58.44 µM 1.07252914233528 0.136952248959648 no 499 0.141741215848076 161 2989575
SGTC_3080 9117754 49.47 µM 1.07181118678731 0.137113513915748 no 500 0.141902423725351 189 9550191
SGTC_3249 9135183 49.47 µM 1.07148836059294 0.137186068402457 no 501 0.141974950727009 161 4902779
SGTC_838 0109-0203 71.4 µM 1.06492582531351 0.138666670481716 no 502 0.143454748630903 161 759422
SGTC_1606 st000094 49.2 µM 1.06332192998914 0.139030181464095 no 503 0.143817991690064 167 1242210
SGTC_751 0833-0568 350 µM 1.06313370075516 0.139072884718089 no 504 0.14386066165703 167 6954252
SGTC_1346 1488-2224 62.4 µM 1.0629503737315 0.139114484397388 no 505 0.143902228543547 167 3722427
SGTC_512 prima-1 270 µM 1.06228377044243 0.139265818166426 no 506 0.144053439972348 145 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_551 k048-0028 34.9 µM 1.05970316970811 0.139852727893699 no 507 0.144639830163662 184 6836383
SGTC_1550 gossypolone 36.6 µM 1.05739286073075 0.14037958912135 no 508 0.145166164217415 168 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2940 9060638 45.86 µM 1.05275073801906 0.141442285968524 no 509 0.146227623942671 155 4027022
SGTC_2183 6420625 130.508 µM 1.05212437225786 0.141586092945171 no 510 0.146371245755983 195 2897619
SGTC_760 0568-0725 82.9 µM 1.05199992384764 0.141614676780052 no 511 0.146399792284609 182 3916171
SGTC_1369 1866-0067 208 µM 1.05105810514654 0.141831124407133 no 512 0.146615952015859 161 3531355
SGTC_219 mitoxanthrone 164.414 µM 1.04758454624909 0.142631349563024 no 513 0.147415030254394 179 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_691 1548-0686 185 µM 1.04646556193077 0.142889785759626 no 514 0.147673068402293 206 46495133
SGTC_3308 9128332 17.569 µM 1.04629495237941 0.142929216854526 no 515 0.147712437581873 172 17332805 YDL196W YDL196W
SGTC_1264 0783-0040 158 µM 1.04330411609336 0.143621650092815 no 516 0.148403732677964 163 2855798
SGTC_1041 0206-0046 107 µM 1.04198830040957 0.143927001419618 no 517 0.148708551617496 172 50494
SGTC_1283 0922-0125 16.4 µM 1.04195423704087 0.143934912056752 no 518 0.148716448215069 163 3360884
SGTC_2433 5607874 27.82 µM 1.04177903597004 0.14397560415434 no 519 0.148757067896492 165 2252428
SGTC_2151 5563267 85.4165 µM 1.04141113570681 0.144061077704131 no 520 0.148842388262503 193 5310824
SGTC_1068 loratadine 26.9 µM 1.03935001607848 0.144540566381382 no 521 0.149320990683074 170 3957 A H1 histamine antagonist.
SGTC_1752 st044819 83.042 µM 1.03710201882256 0.145064753914869 no 522 0.149844157221182 168 441209 YML126C ERG13
SGTC_2212 7123476 200 µM 1.03472625053728 0.145620124103726 no 523 0.150398386570752 155 1085715
SGTC_2369 9071472 200 µM 1.03452677980964 0.145666818236964 no 524 0.150444982023268 151 17296037
SGTC_816 0325-0417 81.3 µM 1.0341087800724 0.145764700505795 no 525 0.150542656046066 176 68101
SGTC_2330 7979373 200 µM 1.03254390520978 0.146131537029957 no 526 0.15090869543524 168 1863007
SGTC_196 k015-0023 18.111 µM 1.02860708191428 0.147057143886275 no 527 0.15183217437062 156 5211998
SGTC_568 1193-0097 7.48 µM 1.02602991671082 0.147665199090795 no 528 0.152438741343872 189 3646150
SGTC_2426 5582046 32.21 µM 1.0236368820798 0.148231316287733 no 529 0.153003408972503 163 2251934
SGTC_2657 nystatin 74.44 µM 1.02289962971056 0.148406019358006 no 530 0.153177652301952 169 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1837 st055472 66.5 µM 1.01899199489831 0.149334290967507 no 531 0.154103383473035 165 676091
SGTC_346 4513-0042 7.16 µM 1.01818658829437 0.149526098767002 no 532 0.154294645937316 181 2827372
SGTC_531 3788-1495 174 µM 1.01772401858147 0.149636334168275 no 533 0.154404564773811 164 2896655
SGTC_2399 5884133 200 µM 1.01677422264599 0.149862850827584 no 534 0.154630423734829 178 722445
SGTC_3098 9119039 49.47 µM 1.01549388286214 0.150168560579232 no 535 0.154935230506476 171 17161528
SGTC_2920 7982904 15.77 µM 1.01457572977121 0.1503880459155 no 536 0.155154056700753 180 6456808
SGTC_3068 9116768 49.47 µM 1.0118447560843 0.151042150495842 no 537 0.155806143358229 191 41904888
SGTC_2597 laccaic acid a 100 µM 1.01001156654576 0.151482284181997 no 538 0.156244874258704 168 5491415 A textile dye.
SGTC_2466 5983409 37.09 µM 1.0095288398559 0.15159832457483 no 539 0.156360538806153 174 2879657
SGTC_2571 chrysanthemic acid 100 µM 1.00864002530455 0.151812137033503 no 540 0.15657365219828 183 2743 An insecticide.
SGTC_2342 7990637 118.86 µM 1.0070152794198 0.152203502178966 no 541 0.156963715829977 195 2033102 YER133W GLC7
SGTC_2070 5230947 200 µM 1.00449498001213 0.152811910622831 no 542 0.157570044843527 205 2835538
SGTC_1694 st024011 44.9 µM 1.00394734320551 0.152944324934445 no 543 0.157701997566849 194 2787533
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.00193943027576 0.153430473255702 no 544 0.158186423655298 230 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1446 4239-0190 62 µM 1.00082428533317 0.15370090956001 no 545 0.158455883215228 181 1340085
SGTC_2586 curcumin 80 µM 1.00030409686015 0.153827169508516 no 546 0.158581682581992 185 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2189 6047310 154.431 µM 0.999557676276117 0.154008460320761 no 547 0.158762306994216 164 711535
SGTC_2709 st078560 56 µM 0.999310917134726 0.154068424320211 no 548 0.158822049259725 206 17250903
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.998441592061827 0.154279798740648 no 549 0.159032636858556 169 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1936 st074407 74.3 µM 0.997777122990885 0.154441492139679 no 550 0.159193722902095 203 809813
SGTC_2073 5212005 126 µM 0.996394853614363 0.154778215488562 no 551 0.159529166267466 189 691789
SGTC_761 k216-0224 480 µM 0.995652536328224 0.154959245362871 no 552 0.159709499535354 197 1340404
SGTC_1203 3992-3522 103 µM 0.995265631702105 0.1550536557068 no 553 0.15980354424383 197 5322312
SGTC_3024 9090631 49.47 µM 0.995053454583014 0.155105446125365 no 554 0.159855133405326 165 25236383
SGTC_2481 5478948 45.16 µM 0.994089874003777 0.15534079068667 no 555 0.160089557345145 177 77792
SGTC_184 1494-0393 24.714 µM 0.993569106153153 0.155468080878964 no 556 0.160216345458864 213 3090647
SGTC_1849 st056239 19.2 µM 0.992726679826669 0.155674139040999 no 557 0.160421584696139 194 5393181
SGTC_3230 9131665 49.47 µM 0.989937432605096 0.15635767607619 no 558 0.161102350851998 166 15943720
SGTC_3186 9110464 49.47 µM 0.98751110671322 0.156953880342071 no 559 0.161696070380775 170 17018021
SGTC_2269 7935389 174.42 µM 0.985586202974727 0.157427936127957 no 560 0.162168105589697 193 97605
SGTC_2416 tofa 880 nM 0.985345525758506 0.157487275044025 no 561 0.1622271887924 149 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_11 0438-0307 1.3 µM 0.984024934574657 0.157813128079054 no 562 0.162551626562207 192 4011476
SGTC_2437 5741531 144.16 µM 0.983576009272076 0.157924000208696 no 563 0.162662012890935 206 2262990
SGTC_1682 st012968 530 nM 0.980662967798232 0.158644683297687 no 564 0.163379485738458 169 24207270
SGTC_1811 st050069 61.5 µM 0.979988454075171 0.15881186420317 no 565 0.163545908987639 180 3877702
SGTC_2811 7967822 32.47 µM 0.979758575181497 0.158868866975094 no 566 0.163602652313041 164 2232244
SGTC_2391 6285546 200 µM 0.979416991230381 0.158953593869695 no 567 0.163686992531067 173 846083
SGTC_2148 5546263 113.568 µM 0.979206838555788 0.159005735101862 no 568 0.163738895180715 179 792097
SGTC_515 4092-1064 102 µM 0.977829478006942 0.159347751075887 no 569 0.164079334490552 204 717353
SGTC_1579 chlormadinone acetate 49.4 µM 0.976450094169978 0.159690751866278 no 570 0.164420733724302 190 45114258 A steroidal progestin.
SGTC_1375 2910-0797 186 µM 0.973452799839607 0.160437730220401 no 571 0.165164154018828 196 742508
SGTC_832 4083-0019 164 µM 0.972445474675649 0.160689285070022 no 572 0.165414489062902 212 1990758
SGTC_3261 9137475 49.47 µM 0.970334021542613 0.161217404256588 no 573 0.165940012144793 120 17027690
SGTC_1389 3405-0187 19 µM 0.969709207067563 0.161373900473027 no 574 0.166095729924668 194 799890
SGTC_2570 licareol 100 µM 0.966001990441648 0.162304477794779 no 575 0.167021592520479 184 443158
SGTC_640 3381-0960 37.1 µM 0.965237845833171 0.162496725062955 no 576 0.167212847517651 203 1745025
SGTC_2470 5664817 21.68 µM 0.957465346988742 0.164460583355031 no 577 0.169166214505994 185 2859561
SGTC_1893 st059353 36.1 µM 0.956430025753539 0.164723331762259 no 578 0.169427510555952 202 3112488
SGTC_2428 5615643 7.78 µM 0.955413776593591 0.164981504308933 no 579 0.169684244922393 213 2253075
SGTC_875 0709-0210 25.7 µM 0.955173443654555 0.165042597866345 no 580 0.169744996541498 208 6251364
SGTC_175 3793-3120 23.7 µM 0.954625789649792 0.165181868330053 no 581 0.169883485214116 210 5322297
SGTC_2515 chrysin 20.77 µM 0.954113207082746 0.165312288891743 no 582 0.170013170767541 174 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2199 6590217 200 µM 0.952959043766998 0.16560619593692 no 583 0.170305411196119 176 703109
SGTC_3118 9124250 49.47 µM 0.950551077690181 0.166220470418449 no 584 0.170916156679472 178 1504786
SGTC_2793 7325131 81.82 µM 0.949180245960193 0.166570827472492 no 585 0.171264473339339 196 4176441
SGTC_2610 ononetin 44.17 µM 0.948047362916618 0.166860729084824 no 586 0.171552671532729 191 259632
SGTC_2617 dihydrotanshinone i 20.83 µM 0.947942298686234 0.166887631210671 no 587 0.171579414893531 201 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_922 1866-0035 480 µM 0.945903279813469 0.167410284303954 no 588 0.172098960237667 204 3156169
SGTC_2541 muurolladie-3-one 83.07 µM 0.944933088939165 0.167659339147221 no 589 0.172346518639389 226 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1503 4585-0012 61.3 µM 0.94411266126607 0.167870134840687 no 590 0.172556039957196 177 2922052
SGTC_1701 st028638 40.4 µM 0.943656898644364 0.167987309400314 no 591 0.172672503039707 181 3490878
SGTC_336 4111-0029 111 µM 0.94284601447118 0.168195914256223 no 592 0.172879835798463 187 3131175
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.941318459955747 0.168589339363491 no 593 0.173270842760188 211 91467 include heat shock
SGTC_1438 4092-1045 4 µM 0.940987237213076 0.168674724507612 no 594 0.173355699821701 211 1351342
SGTC_2178 5812956 200 µM 0.939140551008986 0.169151286830392 no 595 0.173829293368967 215 5403383
SGTC_1129 3453-1384 223 µM 0.937022032055856 0.169699063008039 no 596 0.174373612496367 204 1084452
SGTC_2047 4141938 200 µM 0.934474489650385 0.170359274858261 no 597 0.175029594555831 227 3807862
SGTC_2517 totarol 10 µM 0.93352219900789 0.170606488929099 no 598 0.175275207105582 195 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3333 9141820 12.094 µM 0.932982999584208 0.170746566556565 no 599 0.175414373005905 195 1939433
SGTC_2387 9077560 195.08 µM 0.93266166406076 0.170830080717578 no 600 0.175497342129731 193 5303272
SGTC_1955 wogonin 32.4 µM 0.932038429618536 0.170992132022401 no 601 0.175658332720285 164 5281703 A flavanone.
SGTC_3030 9087619 49.47 µM 0.931309058880987 0.171181905368762 no 602 0.175846858665923 214 25236973
SGTC_1035 k081-0041 55.2 µM 0.931160123667168 0.171220673042507 no 603 0.175885370822222 214 731709
SGTC_1157 4092-0394 27.6 µM 0.929666572704534 0.171609753116895 no 604 0.176271873468624 182 3659885
SGTC_2236 dapsone 200 µM 0.929211749234853 0.171728349806102 no 605 0.176389679827919 187 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_753 1322-0200 289 µM 0.927741168967603 0.172112166545561 no 606 0.17677092380437 191 5403907
SGTC_24 0417-1663 219 µM 0.927613978754998 0.172145388489376 no 607 0.176803921981755 193 4329390
SGTC_911 3456-4043 236 µM 0.924780913059154 0.172886442791214 no 608 0.177539940481481 200 914281
SGTC_2154 5570129 200 µM 0.923941064607635 0.173106514772917 no 609 0.177758500640592 212 673366
SGTC_1461 k072-0203 53.8 µM 0.923837705528106 0.17313361107723 no 610 0.177785410286421 193 5418714
SGTC_2836 9010338 19.48 µM 0.922874728709734 0.173386191990865 no 611 0.178036245812174 195 2994051
SGTC_3132 9126706 49.47 µM 0.922259263179017 0.17354774635449 no 612 0.178196678662246 217 850858
SGTC_3257 9139206 32.98 µM 0.921881505136324 0.173646951990473 no 613 0.178295193626816 199 4910041
SGTC_1006 4099-6547 255 µM 0.920814624002134 0.173927327780864 no 614 0.178573609286237 207 3146833
SGTC_1053 3366-3204 134 µM 0.919599718721147 0.174246954576173 no 615 0.17889098688648 216 3632071 YPR165W RHO1
SGTC_2208 7283366 200 µM 0.915169649171608 0.175415611433418 no 616 0.180051287697908 210 898663
SGTC_581 0958-0271 211 µM 0.911917017582256 0.176276814776596 no 617 0.180906201245901 209 4591145
SGTC_14 0354-0009 295 µM 0.910713558913605 0.176596132996949 no 618 0.181223159030462 226 1713507
SGTC_1776 st049249 45.9 µM 0.908426533603987 0.17720396540156 no 619 0.18182645617679 217 1822314
SGTC_1193 1488-0126 41.5 µM 0.907047440018395 0.177571130801113 no 620 0.18219085537845 199 1384710
SGTC_2027 5150920 200 µM 0.905341955276265 0.17802585702455 no 621 0.182642128020938 197 786715
SGTC_1843 st055809 45.5 µM 0.904847781468661 0.178157753580608 no 622 0.182773017120593 208 16413835
SGTC_466 geldanamycin 89.2 µM 0.903846445281062 0.178425202186276 no 623 0.183038415013651 181 5288382 HSP90 inhibitor.
SGTC_1005 4092-0690 4.4 µM 0.902029919342198 0.178911026462656 no 624 0.183520487212032 212 1529343
SGTC_2886 9058944 51.95 µM 0.900921929558205 0.179207763290629 no 625 0.183814915268576 159 4949929
SGTC_726 3448-4391 34.2 µM 0.898431922554287 0.179875754459735 no 626 0.184477662013836 217 1356692
SGTC_3284 9108171 64.8615 µM 0.898019314562967 0.179986595158275 no 627 0.184587626207775 198 8687505
SGTC_2638 epoxomicin 18 µM 0.897874222766351 0.180025581995718 no 628 0.184626304320956 193 9915668 A protesome inhibitor.
SGTC_506 n9-isopropylolomoucine 153 µM 0.896981789473961 0.180265499547727 no 629 0.184864317183304 193 6610355
SGTC_720 r052-1644 49.9 µM 0.896957073632371 0.180272146892118 no 630 0.184870911635929 216 1422863 YOR257W CDC31
SGTC_1417 3966-0327 90.4 µM 0.896746272896681 0.180328848161159 no 631 0.184927161482371 202 651118
SGTC_146 3448-8650 53.125 µM 0.896244454786486 0.180463872426572 no 632 0.185061108886953 232 2891488 YIL048W NEO1
SGTC_2711 st079103 59.1 µM 0.895806504834419 0.180581763491586 no 633 0.185178057574912 197 54693780
SGTC_952 1185-0122 232 µM 0.895757184357794 0.180595043019112 no 634 0.185191230824835 194 678600
SGTC_2737 bleomycin 30.5 nM 0.89297120628578 0.181346161167749 no 635 0.185936296246376 221 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_881 0833-0569 170 µM 0.89221414067758 0.181550608586613 no 636 0.186139082105264 202 5418700
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.888490222928915 0.182558360386021 no 637 0.187138556359072 185 6708561
SGTC_2282 7944268 200 µM 0.88765237816795 0.18278557513096 no 638 0.187363884777868 207 2970414
SGTC_1419 3993-2473 62.6 µM 0.886807482667479 0.183014880647012 no 639 0.187591279173906 222 704026
SGTC_456 gingerol 170 µM 0.88669407979999 0.183045671959429 no 640 0.187621813291563 231 442793 A herb.
SGTC_370 0180-0345 38.7 µM 0.885927668350649 0.18325385384237 no 641 0.187828252740612 188 3989527
SGTC_140 0062-0056 502.533 µM 0.885417401094277 0.183392540609311 no 642 0.18796577532664 188 3758964
SGTC_3324 9138759 60.749 µM 0.884494581760135 0.183643522026749 no 643 0.188214643015054 203 45595710
SGTC_940 3232-1287 54.8 µM 0.884402695604287 0.183668524238948 no 644 0.188239434175199 206 1585493 YIL048W NEO1
SGTC_42 0133-0086 60.653 µM 0.883961898778226 0.183788494493007 no 645 0.188358390493795 250 162923 Model of phenazepam hydroxylation.
SGTC_563 tetrahydrosecaminediol 614 µM 0.883731134690873 0.183851320274414 no 646 0.188420684490217 193 334274 A psychoactive constituent of the cannabis plant.
SGTC_1421 4029-0249 71.4 µM 0.883625806276022 0.183880000498869 no 647 0.18844912176783 228 2894095
SGTC_2682 pyrogallin 40.03 µM 0.880341656490969 0.184775650080314 no 648 0.189337126254782 201 822798 An ATP competetive kinase inhibitor.
SGTC_1259 0671-0132 43 µM 0.878842019200404 0.185185529782445 no 649 0.189743469850491 209 X1259
SGTC_3083 9117465 49.47 µM 0.87532614373768 0.186148697827295 no 650 0.190698236479412 219 16420915
SGTC_686 1319-0111 510 µM 0.874891005628718 0.18626811870583 no 651 0.190816606729978 237 4562600
SGTC_1341 1486-1360 280 µM 0.87345949406187 0.186661322789684 no 652 0.191206337617004 231 3976547
SGTC_2815 7968870 71.43 µM 0.87236779578454 0.186961532910289 no 653 0.191503881629303 205 2977326 YHR190W ERG9
SGTC_10 0279-0212 42.575 µM 0.872266301361748 0.186989458404082 no 654 0.191531558492463 215 39851 YBR002C RER2
SGTC_931 2812-0076 566 µM 0.871534142248852 0.187190983402624 no 655 0.191731286069005 213 3450959
SGTC_2452 5863136 48.41 µM 0.871016435699711 0.187333561890576 no 656 0.191872589521586 230 2184096
SGTC_1091 telmisartan 47.6 µM 0.870452410782418 0.187488973039305 no 657 0.192026607705962 229 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1435 4092-0789 56.7 µM 0.869437347327591 0.187768863787653 no 658 0.192303981439858 227 2248285
SGTC_443 clozapine 122 µM 0.869264476063283 0.187816556530029 no 659 0.192351244222204 215 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1724 st037281 8.293 µM 0.86773387899326 0.18823915295084 no 660 0.192770017308149 222 574124 YDL195W SEC31
SGTC_2210 7115885 190.385 µM 0.866871060546235 0.18847763469282 no 661 0.193006330726255 218 2927039
SGTC_1162 k048-0130 20.1 µM 0.865311920410129 0.18890905102139 no 662 0.193433804936661 214 6797406
SGTC_876 0720-0963 56.8 µM 0.862836888209657 0.189595144313664 no 663 0.194113577175542 209 765861
SGTC_1637 st007924 17.4 µM 0.861734393914509 0.189901255022965 no 664 0.194416847213578 196 683336
SGTC_97 0535-0701 19.132 µM 0.860330328748034 0.190291537360082 no 665 0.194803489553825 199 2832013 YGL099W LSG1
SGTC_2393 9031399 185.94 µM 0.859649885168441 0.190480854642582 no 666 0.194991033815191 223 1526623 YDL150W RPC53
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.858813807080215 0.190713631826514 no 667 0.19522162440329 252 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3175 9106517 49.47 µM 0.858205920105163 0.190882986606081 no 668 0.195389383808011 216 41468073
SGTC_2831 7999036 19.48 µM 0.858073275649111 0.190919953057946 no 669 0.195426001516716 219 2988270
SGTC_1218 1348-1416 30.7 µM 0.857396035933636 0.191108760254263 no 670 0.195613024663167 228 6787668
SGTC_2335 9018011 154.17 µM 0.857117881604116 0.19118633986698 no 671 0.195689869848749 205 6458208
SGTC_2251 lansoprazole 556 µM 0.857095051302297 0.19119270829 no 672 0.195696177947981 201 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2191 5911152 200 µM 0.85628187856881 0.191419624435399 no 673 0.195920941157922 220 2875902
SGTC_2891 9063876 19.48 µM 0.854843411526059 0.191821433144845 no 674 0.196318920856654 196 6472478
SGTC_308 4092-1169 104 µM 0.85269672779501 0.192422028344554 no 675 0.196913752984979 225 2268590 YDL196W YDL196W
SGTC_1882 5615643 20 µM 0.851110722350591 0.192866495700033 no 676 0.197353924868343 210 2253075
SGTC_1464 k208-0027 110 µM 0.847809197468324 0.193793735179957 no 677 0.198272120023059 230 X1464
SGTC_253 dyclonine 31.25 µM 0.84562657169942 0.194408219218439 no 678 0.198880548724587 206 3180 An oral anasthetic.
SGTC_2722 naftopidil 47.16 µM 0.845195228046054 0.194529797476734 no 679 0.199000923112078 219 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_423 5-fluorouracil 457 µM 0.84434497415775 0.194769584985203 no 680 0.199238330640423 227 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1504 k297-0033 30 µM 0.839886426075677 0.196029919794763 no 681 0.200486034525976 166 4388117
SGTC_2786 7743617 45.45 µM 0.837472280894409 0.196714406011744 no 682 0.201163575755985 212 583674
SGTC_2309 7664088 163.95 µM 0.837332787072539 0.196754001093989 no 683 0.201202767271295 218 704922
SGTC_3078 9116413 49.47 µM 0.836304044142716 0.197046157039529 no 684 0.20149193931057 250 17177322
SGTC_161 4065-0411 162.148 µM 0.835988550479766 0.197135807659516 no 685 0.201580672122955 225 1906281 YLR208W SEC13
SGTC_756 0508-1999 28.3 µM 0.835194367534907 0.19736159177432 no 686 0.201804140241943 229 6753853
SGTC_1816 st051957 91.6 µM 0.834652900283336 0.197515619112728 no 687 0.20195658393671 225 674121
SGTC_459 nigericin 15.3 µM 0.832072623741224 0.198250609854652 no 688 0.202683976635087 235 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_251 melphalan 456.522 µM 0.831101175170187 0.198527753810402 no 689 0.202958237961728 242 460612 A DNA alkylator.
SGTC_1965 Pectolinarigenin 58.4 µM 0.83019939201771 0.198785232019812 no 690 0.203213029469253 236 5320438 An anti-inflammatory.
SGTC_1327 1436-0082 2.18 µM 0.829166703322829 0.199080333686318 no 691 0.203505041655939 228 15992205
SGTC_1293 1000-1278 195 µM 0.828524701834273 0.199263925345319 no 692 0.203686705775365 241 678847
SGTC_1878 temozolomide 1 mM 0.828016188025622 0.199409416186718 no 693 0.203830666118855 222 5394 DNA alkylating agent.
SGTC_1201 1889-3372 45.9 µM 0.827935939857628 0.199432381824252 no 694 0.203853389927606 224 5392199
SGTC_2353 9059630 146.67 µM 0.827414449156351 0.199581662232626 no 695 0.204001096811095 222 4779114
SGTC_2101 5377231 179.231 µM 0.826430409465702 0.199863533668331 no 696 0.204279989570839 231 2844213
SGTC_2689 tacrolimus 100 µM 0.822710657641184 0.200931192270103 no 697 0.205336276595573 222 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_188 3229-0966 278.469 µM 0.821052686236483 0.201408170543182 no 698 0.205808129256111 236 5722370
SGTC_1625 st003711 30.1 µM 0.820140111242771 0.201670996609561 no 699 0.206068119081627 226 24207034 YER133W GLC7
SGTC_1405 3909-7894 12 µM 0.817840973331596 0.202334069712659 no 700 0.206723999281764 231 7104060
SGTC_1739 st037196 92.5 µM 0.817682523666653 0.202379814690699 no 701 0.20676924605235 217 612214
SGTC_1154 4088-0362 150 µM 0.81695712762707 0.202589318048329 no 702 0.206976464466542 232 6618304
SGTC_1567 st069303 68.4 µM 0.816626693939894 0.202684794347811 no 703 0.207070897689348 231 5581319
SGTC_1197 1601-0112 267 µM 0.815200995613861 0.203097047227588 no 704 0.207478634038904 245 7350313
SGTC_3297 9117502 71.43 µM 0.814617559805237 0.203265896938267 no 705 0.207645627946674 212 7453720
SGTC_1038 k292-0204 154 µM 0.813261473608616 0.20365867968455 no 706 0.208034080372326 229 4454212
SGTC_2331 7980721 200 µM 0.81292457814536 0.203756329699571 no 707 0.208130650940258 235 2981221
SGTC_3287 9117173 37.0625 µM 0.812342318636688 0.203925164906083 no 708 0.20829761709753 200 2789709
SGTC_1870 st057514 26.5 µM 0.812068674219032 0.204004541152297 no 709 0.208376113445367 239 5393161
SGTC_1761 st044296 37 µM 0.810641777404563 0.204418740371804 no 710 0.208785708947289 251 1826700
SGTC_986 1493-0483 84 µM 0.810365094763358 0.204499113637865 no 711 0.208865186506323 232 40079
SGTC_2957 9076800 11.52 µM 0.809822595465548 0.204656758298821 no 712 0.20902107207979 232 16459615
SGTC_32 0928-0142 34.1 µM 0.809183427766938 0.204842586532254 no 713 0.209204822928535 243 2244242
SGTC_2164 5685496 200 µM 0.807609978238757 0.205300470240649 no 714 0.209657570374769 230 759046
SGTC_1047 2043-3044 82 µM 0.807346876684045 0.205377093737363 no 715 0.209733331920951 269 669592
SGTC_64 000l-0018 272.079 µM 0.806610927389229 0.205591515641676 no 716 0.209945338054948 243 6811119
SGTC_1507 4075-3230 155 µM 0.806239963397865 0.205699647909618 no 717 0.210052249990662 226 659771
SGTC_250 brefeldin a 552.239 µM 0.805493768089878 0.205917258535034 no 718 0.210267400565031 223 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1594 piperine 70.1 µM 0.805318462697046 0.205968402106421 no 719 0.210317965154371 218 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3224 9130643 49.47 µM 0.805052563981957 0.206045989740114 no 720 0.210394673850179 245 17644395
SGTC_1921 5740136 50 µM 0.804836744979151 0.206108977158478 no 721 0.210456947203837 218 1774243
SGTC_914 3820-6779 408 µM 0.804579225089663 0.206184150041909 no 722 0.210531267267647 226 2893481
SGTC_2262 9014885 67.46 µM 0.804420212136221 0.206230575784822 no 723 0.210577165987873 227 6457424
SGTC_1303 1160-0052 261 µM 0.80272811001679 0.206724989027334 no 724 0.2110659509297 230 3562476
SGTC_2474 5321570 43.32 µM 0.800049467186172 0.207509091637163 no 725 0.211841068640976 244 2841384
SGTC_152 4469-0003 551.229 µM 0.799199941723868 0.20775813464871 no 726 0.212087242870641 243 697280
SGTC_1755 st041960 45.185 µM 0.798032540034831 0.20810065265093 no 727 0.21242580352965 247 2257073
SGTC_3253 9135987 49.47 µM 0.797932517349807 0.208130015000896 no 728 0.212454826001436 236 4182430
SGTC_3310 9130229 44.1445 µM 0.797223223873609 0.208338303135258 no 729 0.212660700262649 226 7761258
SGTC_2307 7538926 6.34 µM 0.796720975958332 0.208485865473583 no 730 0.212806549439407 253 96582
SGTC_317 4495-0002 170 µM 0.79639291127582 0.208582285386407 no 731 0.212901848578281 216 15991618
SGTC_3225 9130819 49.47 µM 0.796187961520812 0.208642534522622 no 732 0.212961396838993 255 4547121
SGTC_1505 k297-0037 20.6 µM 0.795704404873934 0.208784726452641 no 733 0.213101932991377 231 4089396
SGTC_1456 k015-0012 13 µM 0.794228551427549 0.2092190605205 no 734 0.213531194921297 247 2989616
SGTC_2906 7926292 26.41 µM 0.794122806019338 0.209250201113379 no 735 0.213561971019554 247 2966319
SGTC_2362 9071156 126 µM 0.790598315087493 0.210289676064678 no 736 0.214589215190712 233 653133
SGTC_1802 st050112 57.9 µM 0.789724104266879 0.210547974825609 no 737 0.214844455539696 238 4662563
SGTC_741 4582-0002 126 µM 0.789265887782482 0.21068343612949 no 738 0.21497830985843 239 2912688
SGTC_379 3970-0972 5.9 µM 0.788844305363903 0.210808112552563 no 739 0.215101505390649 247 2898042 YBL034C STU1
SGTC_2324 6149169 200 µM 0.787743626110667 0.211133825164376 no 740 0.215423340885881 234 2888231
SGTC_439 amiodarone 34.4 µM 0.78739892955238 0.211235888257847 no 741 0.215524186592838 243 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2233 sulbentine 40.3845 µM 0.784884063507496 0.211981403083522 no 742 0.216260773300631 247 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_144 4161-2749 112.381 µM 0.784006535798139 0.212241901901993 no 743 0.216518137647453 255 797501 YMR168C CEP3
SGTC_1892 st058411 7.36 µM 0.782796718623435 0.212601349275534 no 744 0.216873247405884 252 3934738
SGTC_3125 9127534 49.47 µM 0.781483036095323 0.212992058291226 no 745 0.217259225110461 221 1639235
SGTC_1785 bathophenanthroline 24 µM 0.781152095474535 0.213090551052962 no 746 0.217356522470983 238 72812 An iron chelator.
SGTC_2238 6671620 73.2395 µM 0.779644568414831 0.213539549167405 no 747 0.217800057388342 234 729941
SGTC_2691 st077356 60.2 µM 0.77843159948007 0.213901216734676 no 748 0.21815730801572 245 2839272
SGTC_1653 st012112 65 µM 0.778399439785332 0.213910810551936 no 749 0.21816678446842 240 720429
SGTC_2122 5258151 111.688 µM 0.777902698702065 0.214059029197883 no 750 0.21831318860414 232 2173356
SGTC_3211 9128781 49.47 µM 0.772405166433573 0.21570338133929 no 751 0.219937247436128 232 17194361
SGTC_342 k048-0088 23.3 µM 0.771446483244925 0.215990878489081 no 752 0.220221165979001 256 6820570
SGTC_2683 piperine 63.03 µM 0.770970140311318 0.216133810316869 no 753 0.220362315304556 256 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3167 9103034 49.47 µM 0.769373708207941 0.216613236201408 no 754 0.22083574598797 230 5127859
SGTC_89 0302-0250 142.109 µM 0.768660480355624 0.216827624921374 no 755 0.221047445685699 260 4203518 YLR208W SEC13
SGTC_1814 st052110 31.539 µM 0.768218509930679 0.216960538081085 no 756 0.221178689241626 254 674163
SGTC_2611 pyromycin 23.93 µM 0.766267042578392 0.217547962885534 no 757 0.221758712103392 240 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_5 0352-0601 109.883 µM 0.765952771510157 0.217642649558091 no 758 0.221852202166936 238 762456
SGTC_2035 5154463 94.595 µM 0.765317292716352 0.217834185490111 no 759 0.22204131459192 270 2769623
SGTC_1557 sumaresinolic acid 42.3 µM 0.76470378840047 0.218019190425546 no 760 0.222223974901424 238 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_348 k064-0012 10.7 µM 0.76441500363304 0.21810630609246 no 761 0.222309985247446 237 5066323
SGTC_6 0844-0013 19.835 µM 0.763757578618572 0.218304701677686 no 762 0.222505860549014 271 1584900
SGTC_2874 9043904 71.43 µM 0.76371417083542 0.218317804795454 no 763 0.222518797064675 245 4463428
SGTC_2959 9079155 11 µM 0.762620564135833 0.218648071500045 no 764 0.22284485844347 249 16189457
SGTC_2826 7992541 19.48 µM 0.762578250980544 0.218660855751902 no 765 0.222857479676742 300 2985066
SGTC_775 4577-0580 57.3 µM 0.761502652878829 0.218985975189931 no 766 0.223178447468511 244 2006902
SGTC_3052 9092717 49.47 µM 0.760488583439447 0.219292750928823 no 767 0.223481295443168 261 25237534
SGTC_3119 9125183 49.47 µM 0.760153122367878 0.219394288774161 no 768 0.223581531050059 209 22695334
SGTC_3348 9149464 3.537 µM 0.759208464258102 0.219680364366387 no 769 0.223863931774423 237 1951442
SGTC_3277 9138724 49.47 µM 0.758473284163894 0.219903150804588 no 770 0.224083850316915 219 15943418
SGTC_1290 0986-0249 10.2 µM 0.757175356952059 0.220296786538734 no 771 0.224472405967781 265 53329
SGTC_1721 st082152 9.2685 µM 0.756947209177812 0.220366020983708 no 772 0.224540745207687 258 5296051
SGTC_1037 k284-1091 78.7 µM 0.756548171336447 0.220487144249691 no 773 0.224660301124316 244 3334711
SGTC_2008 4012253 172 µM 0.756472270875572 0.220510187263955 no 774 0.224683045783709 241 603940
SGTC_633 0437-0093 97.7 µM 0.754878519692605 0.220994361058357 no 775 0.225160937666864 242 2831118
SGTC_246 cycloheximide 667 µM 0.754558901867227 0.221091532583071 no 776 0.225256845464161 256 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1169 aniline yellow 25.8 µM 0.754188135130258 0.221204285234873 no 777 0.225368130509437 263 6051 A DNA damaging agent.
SGTC_49 0717-0965 32.132 µM 0.752903991490708 0.221595056093123 no 778 0.22575380470077 272 5889349 YGL099W LSG1
SGTC_1652 st011932 78 µM 0.752221331527731 0.221802953193267 no 779 0.225958983759725 249 1551076
SGTC_2106 5357045 167.29 µM 0.751601111150824 0.221991931513956 no 780 0.226145487459896 240 668842
SGTC_739 1486-1183 203 µM 0.75001670159504 0.222475111043025 no 781 0.226622322932925 244 4346692
SGTC_2932 9016711 44.54 µM 0.749867362379456 0.222520684248954 no 782 0.226667296515962 249 7117328
SGTC_275 trichlorophene 5.69 µM 0.745339054928522 0.223905093969081 no 783 0.228033388435176 247 62616
SGTC_2241 6772625 37.8075 µM 0.7443455839426 0.224209474726012 no 784 0.228333715250385 249 2285411
SGTC_2226 7298446 200 µM 0.743560445652607 0.224450192406473 no 785 0.228571220156141 254 3283010
SGTC_704 1310-0270 142 µM 0.743481808552123 0.224474310046445 no 786 0.228595015578822 266 5718033
SGTC_2221 6807166 181.081 µM 0.741861406894853 0.224971607094433 no 787 0.229085655349222 242 674925
SGTC_329 k048-0121 21.3 µM 0.741838270728695 0.224978712041948 no 788 0.229092665000145 240 6832902
SGTC_3095 9117207 49.47 µM 0.739397593488773 0.225728940161978 no 789 0.229832801576029 232 17015229
SGTC_3108 9121785 49.47 µM 0.73818073081143 0.226103513831879 no 790 0.230202315334591 247 17140271
SGTC_2431 5490079 200 µM 0.737213890071466 0.22640137622461 no 791 0.230496143926044 283 5722345
SGTC_796 1234-0020 70.7 µM 0.735969205176478 0.22678516237276 no 792 0.23087471944086 248 46495034
SGTC_892 0929-0076 29 µM 0.73463813296887 0.227195991035946 no 793 0.231279953878328 259 5751038
SGTC_1294 1000-1494 117 µM 0.733056729262004 0.227684627999697 no 794 0.23176191504624 248 712797 YDL207W GLE1
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.733040240855533 0.227689725856677 no 795 0.231766943129862 276 65057 A dermal irritant. YDR527W RBA50
SGTC_2298 7976326 193.81 µM 0.732985185908051 0.227706748115507 no 796 0.231783732389579 230 2235818
SGTC_2679 rapamycin 1 nM 0.732700519313665 0.227794774673952 no 797 0.23187055358625 247 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.732151704433401 0.227964537017836 no 798 0.232037989160599 261 6710655
SGTC_2804 7954240 19.48 µM 0.731299816687453 0.228228188393949 no 799 0.232298021218487 255 828705
SGTC_1773 st048542 73.5835 µM 0.730053049077577 0.22861436027258 no 800 0.232678879362652 270 3237138
SGTC_1011 4112-3381 17.4 µM 0.726456930177338 0.229730269814259 no 801 0.233779350868255 256 2877139
SGTC_2181 6316240 54.2555 µM 0.725021537102082 0.230176536150527 no 802 0.234219408948723 265 12779990
SGTC_61 0978-8327 98.565 µM 0.723543296698428 0.230636630229908 no 803 0.234673081940815 251 6150059 YHR072W ERG7
SGTC_167 3672-0051 66.205 µM 0.72302251380551 0.230798843320801 no 804 0.234833026239843 248 3237971
SGTC_1362 1611-0397 101 µM 0.722686372293749 0.230903578271451 no 805 0.234936294950133 263 27816
SGTC_1775 st081588 35.1725 µM 0.72243037605507 0.230983359360765 no 806 0.235014958422903 267 1426443 YGL099W LSG1
SGTC_450 aminopyrene 156 nM 0.72170388472846 0.231209853770288 no 807 0.23523827659387 267 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_891 0929-0073 133 µM 0.721449059511011 0.231289328642688 no 808 0.235316635767822 273 5603632
SGTC_1499 4480-0877 67.3 µM 0.720482271590352 0.231590988930688 no 809 0.235614055641712 255 2861909
SGTC_1509 1326-1131 80 µM 0.719916143784068 0.231767735711549 no 810 0.235788313800326 236 768313
SGTC_3105 9121040 49.47 µM 0.719306833899731 0.231958048003846 no 811 0.235975943078509 227 41448907
SGTC_1568 digitonin 820 nM 0.715779546969585 0.233061471673696 no 812 0.237063741765138 290 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2898 9056270 58.44 µM 0.713476861698149 0.233783378822341 no 813 0.237775363040811 216 19154699
SGTC_1767 st044992 70.3 µM 0.71336224345558 0.233819344754811 no 814 0.237810815219667 281 9600693
SGTC_538 2922-0838 53.3 µM 0.712648488887087 0.234043382005591 no 815 0.238031649441351 253 777039
SGTC_1980 st071811 45.7 µM 0.711399743975976 0.23443563081315 no 816 0.238418278805341 265 4974850
SGTC_1199 1638-0010 4.46 µM 0.709828649575676 0.234929650529214 no 817 0.238905200283033 257 3111136
SGTC_2549 cedrol 20.94 µM 0.706074038799159 0.236112588582629 no 818 0.240071047731395 264 6708665 A sedative which affects the nervous system.
SGTC_978 1416-0512 87.4 µM 0.704239021459519 0.23669192581808 no 819 0.240641966957995 280 6814003
SGTC_279 1273-0055 2.93 µM 0.701376795835096 0.237597124036481 no 820 0.241533949541671 284 2847562
SGTC_2351 9026858 72.31 µM 0.700068341800149 0.238011563336679 no 821 0.241942312737617 284 1409300
SGTC_2648 atorvastatin 78.68 µM 0.699575839272722 0.238167661011974 no 822 0.242096117738935 269 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_141 0443-0274 32.331 µM 0.699178197344745 0.238293733730422 no 823 0.242220337129179 242 1627241
SGTC_3252 9135871 49.47 µM 0.698888716233975 0.238385536955234 no 824 0.242310789880115 286 17682838
SGTC_216 k038-0035 28.382 µM 0.698504580631529 0.238507387881778 no 825 0.242430847114466 268 4444231 YPR107C YTH1
SGTC_907 3448-6986 75.5 µM 0.698351055437261 0.23855609685287 no 826 0.242478838687965 276 590582
SGTC_873 0591-4978 488 µM 0.69769063979835 0.238765689139584 no 827 0.242685341555435 284 3305145
SGTC_1280 0880-0253 10.1 µM 0.697117728410971 0.238947592280125 no 828 0.242864560142875 276 6836607
SGTC_1967 st070177 51.4 µM 0.696494093601137 0.23914568654876 no 829 0.243059727450017 276 5729214
SGTC_110 0850-0284 111.64 µM 0.696491411267503 0.239146538771525 no 830 0.243060567072901 247 3906265
SGTC_2204 7233102 200 µM 0.696212489452834 0.239235166008889 no 831 0.243147883617057 259 2172480
SGTC_1034 k072-0165 12.7 µM 0.694373852165302 0.239819840711092 no 832 0.243723893644307 280 5835461
SGTC_234 nsc-17383 10.7 µM 0.692051408479681 0.240559475526762 no 833 0.24445252265274 257 408974
SGTC_1668 st014914 51.6 µM 0.690749178570257 0.240974742968905 no 834 0.244861589112396 281 2839556
SGTC_822 1487-0950 154 µM 0.690341237876315 0.241104911122907 no 835 0.244989810316152 251 1958375
SGTC_3034 9090421 49.47 µM 0.684498386677851 0.242973471144094 no 836 0.246830253887542 260 17173761
SGTC_1270 0831-1170 17.3 µM 0.683657320281937 0.243243090022761 no 837 0.247095789987707 273 6764716
SGTC_376 3970-0862 59.1 µM 0.683476084531556 0.243301209556983 no 838 0.247153028583347 292 3135186
SGTC_1002 4049-0206 172 µM 0.683049619686445 0.243437999917254 no 839 0.24728774437837 281 4662749
SGTC_889 0919-1524 82.7 µM 0.681591001303684 0.243906171716832 no 840 0.247748803310315 274 3905452
SGTC_2186 6124449 200 µM 0.680579649136157 0.244231069761255 no 841 0.248068753820458 264 3834182 YLR033W RSC58
SGTC_1860 st056228 74.6 µM 0.678724614382099 0.244827607767884 no 842 0.248656183526606 297 688679
SGTC_3082 9117008 49.47 µM 0.67787718047198 0.245100384447573 no 843 0.248924784860713 282 41448529
SGTC_2923 7992654 58.14 µM 0.677622741391265 0.245182316591232 no 844 0.24900546160827 262 2985126
SGTC_1248 0469-0687 58.6 µM 0.677095857942005 0.245352025590359 no 845 0.249172568389275 269 4017482
SGTC_1368 1852-0141 284 µM 0.67682675405054 0.245438728224275 no 846 0.249257940602768 285 2838987
SGTC_1497 4476-2978 41.3 µM 0.67591004486756 0.245734206458003 no 847 0.249548879894013 268 1528379
SGTC_1951 sophoraflavanone G 9.2 µM 0.675829826355685 0.245760071969879 no 848 0.249574347713934 273 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_803 4488-1585 147 µM 0.674936430940378 0.246048235533674 no 849 0.249858076709224 260 747204
SGTC_969 1313-0238 134 µM 0.674593702843546 0.246158830135082 no 850 0.249966967442079 290 5212874
SGTC_3355 9151058 44.0485 µM 0.673761074059238 0.246427621338632 no 851 0.25023161309734 279 17015728
SGTC_2863 9028737 58.44 µM 0.673536940146233 0.246500003640812 no 852 0.250302877979689 284 6460917
SGTC_166 k072-0058 166.424 µM 0.671455192689309 0.24717283167394 no 853 0.250965297341032 287 5846229
SGTC_618 k072-0232 33.2 µM 0.671114384180484 0.247283075654883 no 854 0.25107383211211 281 5872756 YGL099W LSG1
SGTC_3183 9108214 49.47 µM 0.670298398766295 0.247547135593565 no 855 0.251333793834808 262 4974831
SGTC_452 diindolylmethane 8 µM 0.670088977326658 0.247614930467785 no 856 0.251400535562192 264 3071 Inhibits expression of several cancer promoting factors.
SGTC_1727 st034309 9.9045 µM 0.668093583660884 0.248261385632597 no 857 0.252036928653437 299 870305
SGTC_1291 0993-0025 5.79 µM 0.668024485719203 0.248283787661094 no 858 0.252058981351875 274 4353356
SGTC_2971 9092186 9.93 µM 0.666176096199038 0.248883448093754 no 859 0.252649274926935 259 25236400
SGTC_2061 5245884 80.95 µM 0.66573201787434 0.249027632171749 no 860 0.252791202235219 294 573863
SGTC_3302 9125395 16.351 µM 0.66562689892949 0.249061768867111 no 861 0.252824804363712 268 17599668
SGTC_1861 st057647 17.4 µM 0.665552634260929 0.249085887337042 no 862 0.252848545088347 274 688668
SGTC_851 0394-0702 453 µM 0.665430860467583 0.249125437735856 no 863 0.252887475938692 294 762646
SGTC_117 lucigenin 22.078 µM 0.66495590974542 0.249279726902181 no 864 0.25303934692674 290 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_943 3253-1379 105 µM 0.664358041862397 0.24947401828405 no 865 0.253230590297398 288 668464
SGTC_258 haloperidol 50.781 µM 0.663331399449157 0.249807837789731 no 866 0.25355916542122 300 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.662992674389943 0.249918028468621 no 867 0.253667622907433 264 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1650 st011916 45.8 µM 0.662249107597452 0.250160008691053 no 868 0.2539057934133 297 242528
SGTC_1738 st035555 74 µM 0.661511894321176 0.250400043902729 no 869 0.254142044647381 290 5331140
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.660088338645577 0.250863896113284 no 870 0.254598570823814 269 6857784
SGTC_2688 kanamycin b 96.69 µM 0.659762671081834 0.250970075716753 no 871 0.254703070894338 273 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2875 9039966 71.43 µM 0.65886790531731 0.251261924655329 no 872 0.254990298539973 289 6463691
SGTC_1304 1165-0502 251 µM 0.65766740918106 0.251653776487165 no 873 0.255375934368869 275 767425
SGTC_820 1582-0060 59.9 µM 0.657279831138044 0.2517803540447 no 874 0.25550050126781 284 3848840
SGTC_1181 1222-0449 220 µM 0.656853511858538 0.251919622761034 no 875 0.255637556185568 283 658318
SGTC_2403 6032726 181.2 µM 0.655303392321599 0.252426353692864 no 876 0.256136218563621 277 2881040
SGTC_2472 5377652 49.4 µM 0.655215565885681 0.252455080048335 no 877 0.256164486877372 306 1610903
SGTC_1986 st071812 45 µM 0.654806497787662 0.252588901132666 no 878 0.256296173282572 288 11838594
SGTC_2108 5365811 200 µM 0.654616426453836 0.25265109310649 no 879 0.256357372680978 265 780283
SGTC_1553 gossypol 38.6 µM 0.653899477788079 0.252885753666726 no 880 0.256588285206809 279 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_842 0271-0008 11.1 µM 0.652183402657323 0.253447898445554 no 881 0.257141432819527 268 1221709
SGTC_1217 1183-1422 255 µM 0.651462511033949 0.253684240857501 no 882 0.257373984779188 281 2849664
SGTC_1267 0828-0272 9.49 µM 0.651088762937213 0.25380681872511 no 883 0.257494594938216 284 745334
SGTC_1561 5-methoxyflavone 52.9 µM 0.648532067712782 0.254646169182532 no 884 0.258320438445484 280 94525
SGTC_256 clotrimazole 625 nM 0.648358078122513 0.254703341893865 no 885 0.258376689029929 262 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3222 9128301 49.47 µM 0.648206546142736 0.254753140544656 no 886 0.258425684271296 269 4911358
SGTC_2010 4012422 159 µM 0.646127221484261 0.255436993127817 no 887 0.259098483734559 290 952393
SGTC_3300 9124615 50.48 µM 0.645088813830488 0.255778865566384 no 888 0.25943481625038 285 24824903
SGTC_3090 9117696 49.47 µM 0.643668719078677 0.256246786323927 no 889 0.259895139194377 277 7923821
SGTC_501 nsc-95397 161 µM 0.640015412974522 0.257452597089572 no 890 0.261081289541178 289 262093
SGTC_2468 5987765 72.9 µM 0.63848490442436 0.257958631724427 no 891 0.261579038758875 277 26772094
SGTC_2075 5212009 200 µM 0.637375424965139 0.258325783123336 no 892 0.261940165946842 297 780898
SGTC_1024 4507-0395 26 µM 0.635800938125007 0.25884728023757 no 893 0.262453087969654 280 4201836
SGTC_1792 st045773 43.6 µM 0.635165454682898 0.259057917474189 no 894 0.262660255552706 253 2919270
SGTC_913 3487-1245 167 µM 0.634999680721822 0.259112879456866 no 895 0.262714311615742 274 4016153
SGTC_1295 1013-0063 9.78 µM 0.634978789354281 0.259119806370367 no 896 0.262721124338377 295 6826038
SGTC_589 1227-0070 34.1 µM 0.633382191696796 0.259649470515099 no 897 0.263242045722432 283 2841384
SGTC_1465 k213-0056 144 µM 0.631670956711202 0.260217784974948 no 898 0.263800954942351 288 24048857 YMR208W ERG12
SGTC_1088 bifonazole 369 nM 0.631394507095618 0.260309656153948 no 899 0.263891303337238 281 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2771 fluoxetine 41.05 µM 0.630458222160637 0.260620931346111 no 900 0.264197414175799 311 3386 A selective serotonin reuptake inhibitor.
SGTC_19 0279-0214 38.434 µM 0.628082955523857 0.26141146586987 no 901 0.264974799053711 296 3566274 YBR002C RER2
SGTC_1658 st012944 20 µM 0.627837446063343 0.261493246314078 no 902 0.26505521640304 287 24207260
SGTC_2799 7812892 81.82 µM 0.627381787075333 0.261645063435588 no 903 0.265204501703393 304 20205235
SGTC_2553 4-methylesculetin 85.09 µM 0.627343408054115 0.261657852678562 no 904 0.265217077581463 286 5319502
SGTC_636 0kpi-0074 126 µM 0.627115235268107 0.261733894518074 no 905 0.265291850542025 301 616434
SGTC_2893 9048488 25.97 µM 0.626904068226754 0.261804279050963 no 906 0.265361060198646 305 6467338
SGTC_2730 imipramine 71.33 µM 0.625559806726087 0.262252565208124 no 907 0.265801854474692 281 3696 A tricyclic antidepressant.
SGTC_1387 3342-1166 1.8 µM 0.624759788705161 0.262519542830697 no 908 0.266064362936712 293 3418228
SGTC_107 0358-0022 2.6945 µM 0.6236198790171 0.262900187422446 no 909 0.266438626130512 317 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1394 3474-0001 65.7 µM 0.623333534525348 0.262995849396671 no 910 0.266532682611684 282 5017666 YIL048W NEO1
SGTC_793 0488-0545 106 µM 0.62248125636129 0.263280683756205 no 911 0.266812732453497 299 292548
SGTC_3031 9088762 49.47 µM 0.621964459338462 0.263453475836254 no 912 0.266982619028624 291 205253
SGTC_2192 5915882 198.485 µM 0.621402201151854 0.263641533670899 no 913 0.267167512074655 293 2876149
SGTC_38 0929-0051 58.268 µM 0.620966568964833 0.263787286127352 no 914 0.267310809837264 305 1379719
SGTC_1252 0493-0875 34.8 µM 0.62007419459148 0.26408598220031 no 915 0.267604470361258 283 3960963
SGTC_72 0744-0168 198.391 µM 0.618443751781925 0.264632169662609 no 916 0.268141432442488 326 677577
SGTC_333 3486-0131 40.1 µM 0.616984332204148 0.265121552361108 no 917 0.268622530051697 286 6744690
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.616776303993953 0.265191347235359 no 918 0.268691141849439 291 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_530 4358-1714 28 µM 0.616540531689836 0.265270461719303 no 919 0.268768914838721 291 1564641
SGTC_2918 7977171 22.06 µM 0.615818072737312 0.265512960741481 no 920 0.269007299023106 300 2236483
SGTC_1406 3909-7906 11.9 µM 0.615501777271503 0.265619163183568 no 921 0.26911169798039 306 X1406
SGTC_578 3460-0051 92 µM 0.612000637343546 0.266796177236871 no 922 0.270268667941778 326 2876744
SGTC_3035 9091303 49.47 µM 0.610875518446981 0.267174978785977 no 923 0.270640996679321 305 25237002
SGTC_2277 7947813 106.88 µM 0.60957477885791 0.267613245852976 no 924 0.271071761530746 315 1246798
SGTC_634 1611-4317 11.2 µM 0.607270431739607 0.268390553924126 no 925 0.271835728812699 322 2843522
SGTC_1495 4469-0029 237 µM 0.606769496366416 0.268559680800186 no 926 0.272001947105101 296 793680
SGTC_2942 9052777 62.25 µM 0.605929871992982 0.268843276671909 no 927 0.272280661085412 324 6469503
SGTC_380 3970-0968 6 µM 0.605913747130957 0.268848724560253 no 928 0.272286015134712 290 2891601
SGTC_758 0868-0029 16 µM 0.605111677740503 0.269119778806161 no 929 0.272552397769882 278 762687
SGTC_2015 5119600 184 µM 0.60507264912704 0.269132971775387 no 930 0.272565363221594 315 2828786
SGTC_732 3970-1727 52.7 µM 0.60471105128347 0.26925521930026 no 931 0.27268550193894 308 1275699
SGTC_2929 9013348 24.6 µM 0.604704989766368 0.269257268790574 no 932 0.272687516065611 307 2995952
SGTC_2265 7929201 200 µM 0.60371576157151 0.269591846554834 no 933 0.273016316633324 313 1265108
SGTC_2890 9046729 58.44 µM 0.603688253658704 0.269601153284941 no 934 0.273025462546311 306 903329
SGTC_799 1310-0557 151 µM 0.6036558459116 0.269612117978594 no 935 0.273036237765707 321 5354492
SGTC_1904 st060225 78 µM 0.603326613958441 0.269723521522188 no 936 0.273145715715669 282 66595
SGTC_100 0086-0128 49.5915 µM 0.603017298537998 0.26982820682891 no 937 0.273248590729583 318 93297
SGTC_280 3448-3607 3.04 µM 0.600942670383989 0.270530873346265 no 938 0.273939085649227 290 626179
SGTC_1604 st002052 72.4 µM 0.600890814299282 0.270548448454888 no 939 0.273956355863184 289 6254834 YHR062C RPP1
SGTC_932 2857-0803 154 µM 0.600502433792477 0.270680096839726 no 940 0.27408571968934 306 674898
SGTC_1696 st025591 34.7925 µM 0.600451348729508 0.270697415398079 no 941 0.274102737617107 294 2787147
SGTC_2674 ligustilide 100 µM 0.599791184757382 0.270921270078294 no 942 0.274322704485007 298 5319022 A signalling regulator.
SGTC_2665 lovastatin 100 µM 0.599553679520309 0.271001828201757 no 943 0.274401862625219 307 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_511 blebbistatin 171 µM 0.598455351448996 0.271374519526144 no 944 0.274768071035056 308 3476986 A myosin inhibitor.
SGTC_717 1532-0246 73.2 µM 0.598078858722573 0.271502332066931 no 945 0.274893657995009 293 9561992
SGTC_870 0573-2213 57.6 µM 0.596527223166449 0.272029400778497 no 946 0.275411536564006 287 3916321
SGTC_736 0958-0254 92.6 µM 0.594261586206894 0.272799918454963 no 947 0.276168583532363 314 6812352
SGTC_3002 9075603 71.4286 µM 0.594150452328031 0.272837741676642 no 948 0.276205744414785 315 20105405
SGTC_2523 spermine 47.74 µM 0.594053389139152 0.272870778218047 no 949 0.276238202355474 275 1103 A DNA binding polyamine.
SGTC_1192 1488-0095 21.4 µM 0.593682469903735 0.272997043000542 no 950 0.276362255027379 312 915875
SGTC_1679 SEC14.276 6.7 µM 0.59359727477545 0.273026048402271 no 951 0.276390752105787 318 1005053 YMR079W SEC14
SGTC_731 3966-0296 387 µM 0.591606987699678 0.273704092870849 no 952 0.27705689678515 299 660956
SGTC_93 0109-0045 59.227 µM 0.588962444870695 0.274606313823618 no 953 0.277943233342157 308 88733
SGTC_3093 9117344 49.47 µM 0.58853060531806 0.274753780843825 no 954 0.278088098641358 295 24824913
SGTC_2701 st077767 14.721 µM 0.586215036020072 0.275545179927203 no 955 0.278865509323031 308 5721188
SGTC_115 0527-0192 112.043 µM 0.586146306345036 0.275568686995613 no 956 0.278888600223805 328 4233931
SGTC_2742 clothiapine 36.27 µM 0.584385764459901 0.276171167195126 no 957 0.279480401055727 305 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2774 tamoxifen 10.92 µM 0.583887799126715 0.276341694590402 no 958 0.27964790116985 309 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_492 tmb-8 126 µM 0.583290759645112 0.27654621782882 no 959 0.279848790965638 320 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1641 st009299 47.1 µM 0.583231603385536 0.276566486575015 no 960 0.279868699471567 301 4046054
SGTC_884 0851-0618 334 µM 0.582934668835663 0.276668236445538 no 961 0.279968640493996 320 9642473
SGTC_553 k007-0256 45.7 µM 0.58264381124723 0.276767921719576 no 962 0.280066552930663 309 6287000
SGTC_2371 9071574 200 µM 0.582311522607043 0.276881828137633 no 963 0.280178432759325 308 45596039
SGTC_2288 7946289 167.31 µM 0.582116408713375 0.276948722626898 no 964 0.280244136665142 324 1246052
SGTC_183 3914-0051 30.55 µM 0.581569189377185 0.277136378115095 no 965 0.280428450630958 300 1596232
SGTC_1306 1185-0270 9.02 µM 0.580627989493244 0.277459285057434 no 966 0.280745602008182 316 1548076
SGTC_2434 5670830 169.91 µM 0.580447679006567 0.277521166979817 no 967 0.280806380116787 326 1549830
SGTC_3176 9106582 49.47 µM 0.580240442605125 0.277592298110966 no 968 0.280876242128041 286 17018027
SGTC_2200 6600604 21.907 µM 0.580034010105252 0.277663162168503 no 969 0.280945841486291 347 2904777
SGTC_2149 5554786 194.827 µM 0.579792289952687 0.277746150985985 no 970 0.281027348778977 306 745063 YPR165W RHO1
SGTC_2377 9073351 62.6 µM 0.578884881334771 0.278057796015815 no 971 0.28133342608685 341 7337946 YHR072W ERG7
SGTC_102 gallobenzophenone 83.616 µM 0.578566005100604 0.278167352985464 no 972 0.281441024181676 306 70837
SGTC_729 4092-0585 94.1 µM 0.577758497859349 0.278444884043702 no 973 0.281713589334033 301 2169061
SGTC_180 1486-1293 102.781 µM 0.577732101716511 0.278453958374628 no 974 0.281722501208043 309 4140536
SGTC_2989 9073649 71.4286 µM 0.576980212774766 0.278712499398232 no 975 0.281976411243745 346 21367202
SGTC_1227 3909-8010 46.6 µM 0.57620359789437 0.278979665201015 no 976 0.282238786804519 296 15982272
SGTC_2162 5663267 200 µM 0.57032881584822 0.281004693401222 no 977 0.284227350048813 342 6456493
SGTC_2766 oltipraz 83.91 µM 0.569579084458431 0.281263634816147 no 978 0.284481608860976 300 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_369 0957-0393 4.5 µM 0.568479883033161 0.281643483950885 no 979 0.284854580870067 314 6997992
SGTC_2493 resveratrol 26.09 µM 0.56554289846632 0.282659624361705 no 980 0.285852277189404 285 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_541 4513-1321 94 µM 0.564161016523014 0.283138337806973 no 981 0.286322277860151 317 747515
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.564071797242302 0.283169258637284 no 982 0.286352635401743 313 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1931 st074438 57.1 µM 0.564041611208114 0.283179720613191 no 983 0.286362906776304 327 2787313
SGTC_2053 5265679 138 µM 0.562341297326819 0.283769320245395 no 984 0.286941753216311 324 764595
SGTC_2484 5809818 12.04 µM 0.561753131846853 0.283973408833486 no 985 0.287142114320208 303 2870548
SGTC_1004 4084-0029 199 µM 0.560325705064185 0.28446900605421 no 986 0.287628648640139 324 716894 YLR208W SEC13
SGTC_2202 7226349 200 µM 0.559453235329622 0.284772127584619 no 987 0.287926219178584 294 844334
SGTC_3151 9099821 49.47 µM 0.559293051050895 0.284827797036644 no 988 0.287980868522204 323 17174189
SGTC_1224 0823-0416 294 µM 0.55864182256866 0.285054174400246 no 989 0.288203095594821 323 3598164
SGTC_1810 st050138 53 µM 0.557858795242607 0.285326480662434 no 990 0.288470405142125 355 3444541
SGTC_2746 daunorubicin 9.88 µM 0.55770393723198 0.285380348890856 no 991 0.288523284342634 291 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1818 st052136 56.3 µM 0.557471464117903 0.285461225060837 no 992 0.288602675264159 305 674169
SGTC_1689 st020265 53.493 µM 0.55671438916975 0.285724683051497 no 993 0.288861292067207 330 5758320 YPR016C TIF6
SGTC_405 ebelactone b 50 µM 0.556268598076056 0.285879870030596 no 994 0.289013625310681 314 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_442 cape 100 µM 0.552705791520155 0.28712157747908 no 995 0.290232443471489 311 5281787
SGTC_779 1360-0071 233 µM 0.551627312055892 0.287497951414851 no 996 0.290601860035578 307 7566
SGTC_3113 9123498 49.47 µM 0.551115262897613 0.287676730901513 no 997 0.290777331589449 337 8897275
SGTC_2757 clomiphene 4.22 µM 0.550499846945321 0.287891669894908 no 998 0.290988290917933 344 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3140 9094243 49.47 µM 0.549264596805581 0.288323319707834 no 999 0.291411939783266 342 19291112
SGTC_829 1635-0120 117 µM 0.549204843054398 0.288344207988272 no 1000 0.291432440586101 329 285054
SGTC_2741 miltefosine 3.04 µM 0.549188607419927 0.288349883646203 no 1001 0.291438010955831 313 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_997 3996-0078 137 µM 0.548981027353057 0.288422454189294 no 1002 0.291509235075958 319 735687
SGTC_143 4032-1194 15.74 µM 0.548083642520759 0.288736281328153 no 1003 0.291817235873893 313 1806963
SGTC_1441 4106-0040 13 µM 0.544824313454377 0.289877461445118 no 1004 0.292937177481236 321 2904180
SGTC_2670 beta-carotene 100 µM 0.543886694727036 0.290206138746836 no 1005 0.293259722711707 301 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_742 0kpi-0133 140 µM 0.543725411701588 0.290262693255629 no 1006 0.293315221417308 337 2728852
SGTC_1651 st011928 86.1 µM 0.543331409568446 0.290400873313587 no 1007 0.293450820989286 324 720198
SGTC_507 nimesulide 162 µM 0.542488657994774 0.290696537139145 no 1008 0.293740959378968 327 4495 A COX2 inhibitor.
SGTC_13 0199-0087 65 µM 0.541508940346958 0.291040429845578 no 1009 0.294078418542172 324 4589825
SGTC_813 k007-0158 173 µM 0.540939146006035 0.291240521894774 no 1010 0.294274763915057 325 6523916
SGTC_55 0767-0285 6.563 µM 0.540710781604696 0.291320733590096 no 1011 0.294353472973452 336 3116166
SGTC_2341 7987486 176.74 µM 0.537999245772805 0.29227393211791 no 1012 0.295288784647665 323 1258686
SGTC_25 0118-0223 35.662 µM 0.53592501527473 0.293004073694617 no 1013 0.296005187530324 338 5333628
SGTC_746 1095-0025 46.6 µM 0.535145446754813 0.293278705114712 no 1014 0.296274642973149 332 6749286
SGTC_2953 9074162 66.49 µM 0.53468377429922 0.293441402292665 no 1015 0.296434271643751 323 16451992
SGTC_2445 5742597 35.57 µM 0.534145807632383 0.293631038907784 no 1016 0.296620329647734 322 1774255
SGTC_807 1315-0151 48 µM 0.533783532959388 0.293758774954181 no 1017 0.296745653977806 356 4011080
SGTC_1176 0848-0131 83.3 µM 0.533640368145576 0.293809261163281 no 1018 0.296795186712296 331 6769040
SGTC_306 1672-3436 11.6 µM 0.533534067536084 0.29384675002945 no 1019 0.296831967470222 345 6797378
SGTC_3323 9138564 53.9225 µM 0.532710390090723 0.294137310008529 no 1020 0.297117036338626 320 43912313 YNL103W MET4
SGTC_968 1309-0633 340 µM 0.532135067707486 0.294340339121446 no 1021 0.29731622551854 330 3761976
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.532116360134541 0.294346942040048 no 1022 0.297322703513166 322 756377
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.530913742031394 0.294771554739964 no 1023 0.297739277260611 319 2374 Ca(2+)-ATPase inhibitor.
SGTC_2502 avocadyne acetate 18.59 µM 0.530446046773853 0.294936761825739 no 1024 0.297901353657501 294 3952079
SGTC_1493 4348-0038 111 µM 0.530003103611067 0.295093264893109 no 1025 0.298054889473985 347 800424
SGTC_2378 9074213 121.43 µM 0.529777144929687 0.295173116562138 no 1026 0.298133226616345 323 657714
SGTC_2090 5301565 104.445 µM 0.529611590602339 0.295231628215581 no 1027 0.298190628252492 335 2056344
SGTC_2790 5423970 71.43 µM 0.529190043897283 0.295380639026562 no 1028 0.298336811276672 332 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_132 0417-1715 25.805 µM 0.526903574405833 0.296189475883144 no 1029 0.29913027577113 347 6769098
SGTC_1232 0279-0259 161 µM 0.526767669162915 0.296237584235449 no 1030 0.299177468577789 339 1560000
SGTC_3076 9116187 49.47 µM 0.524687174632022 0.296974494047531 no 1031 0.299900337258746 347 27241210
SGTC_2127 5253358 187.912 µM 0.524512767814661 0.297036306906061 no 1032 0.299960970877372 340 20612
SGTC_2802 7925815 54.55 µM 0.524332836019918 0.297100084080381 no 1033 0.300023531102149 331 1262923
SGTC_1250 0485-0349 40.2 µM 0.523677347841031 0.297332476075926 no 1034 0.300251486743587 334 6842794 YDL195W SEC31
SGTC_353 1988-1175 58.3 µM 0.522048839467692 0.297910194704374 no 1035 0.300818163046064 344 2788357
SGTC_1057 3448-5381 134 µM 0.521891032864034 0.297966204297711 no 1036 0.300873101053649 308 5497911
SGTC_833 3852-0053 558 µM 0.520621964471486 0.29841680348353 no 1037 0.301315072646446 336 3123681
SGTC_1366 1683-0113 21.9 µM 0.518023484897435 0.299340393474032 no 1038 0.302220941904544 325 708623
SGTC_2728 chlorpromazine 9.18 µM 0.51774280797374 0.299440233349437 no 1039 0.302318863220508 368 2726 A thorazine and dopamine antagonist.
SGTC_1602 st001878 87.6 µM 0.517068900249632 0.299680011376218 no 1040 0.302554031240578 353 595405 YLR310C CDC25
SGTC_1994 st072947 40.9 µM 0.5161636770645 0.300002228821178 no 1041 0.302870048482017 340 5286565 YDL195W SEC31
SGTC_2161 5662504 8.5105 µM 0.515783953295603 0.30013743951502 no 1042 0.303002655637318 303 2859334
SGTC_1674 st016616 23.6 µM 0.514228004066518 0.300691763996816 no 1043 0.303546295433797 327 625830
SGTC_957 1187-1561 14.1 µM 0.511601376182693 0.301628576619681 no 1044 0.304465011067485 317 1538454
SGTC_985 1493-0307 8.71 µM 0.510892238064987 0.30188172255903 no 1045 0.30471325829043 358 3278274
SGTC_2753 fluvastatin 17.09 µM 0.510601652005552 0.301985482642494 no 1046 0.304815009429758 353 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1571 st070080 73.4 µM 0.510527834712046 0.302011843266686 no 1047 0.304840859577636 316 4315245
SGTC_2142 5622915 118.518 µM 0.509855223013928 0.302252084769227 no 1048 0.30507644697209 323 5322196
SGTC_3269 9137823 49.47 µM 0.509128174956247 0.302511866094447 no 1049 0.305331191994875 321 17682936
SGTC_454 lyso-paf C-16 6.67 µM 0.506384491826329 0.303493110984695 no 1050 0.306293379642646 351 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1762 st045503 25.4615 µM 0.504775446395825 0.304069227023072 no 1051 0.306858281614949 327 4645554
SGTC_1758 st042942 75.2445 µM 0.503968340131468 0.304358393526058 no 1052 0.307141812562902 328 669317
SGTC_1077 5-fluorocytosine 377 nM 0.502967803907641 0.304717031122929 no 1053 0.307493454257809 365 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2425 5628681 7.85 µM 0.502885640879804 0.304746490428086 no 1054 0.307522338588008 347 5714958
SGTC_1171 0368-0077 21.4 µM 0.502568094556314 0.304860357602887 no 1055 0.307633982898698 354 3239779
SGTC_1396 3511-0007 98.6 µM 0.500216612379145 0.305704150217776 no 1056 0.308461281148197 339 X1396
SGTC_2583 asiatic acid 100 µM 0.500165965896009 0.305722335292517 no 1057 0.30847911031316 354 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2576 guaiol 23.12 µM 0.499781664786751 0.305860337666323 no 1058 0.308614411179487 319 227829
SGTC_2915 7971052 15.16 µM 0.498825988676782 0.306203640068842 no 1059 0.308950988648008 319 5741558
SGTC_473 2-arachidonoylglycerol 10 µM 0.498423105719987 0.30634841658197 no 1060 0.309092927214288 331 5282280 An endocannabinoid.
SGTC_272 doxorubicin 8.13 µM 0.497278371335944 0.306759943331763 no 1061 0.309496380882707 344 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.496809293979057 0.306928644902745 no 1062 0.309661770311738 357 23665772 A membrane-active detergent.
SGTC_771 0250-0039 27.3 µM 0.496165058765503 0.307160407854615 no 1063 0.309888980514752 364 3005115
SGTC_1706 st031321 9.9705 µM 0.495263868142138 0.307484739523049 no 1064 0.310206936140232 325 6103185
SGTC_3307 9126885 69.2785 µM 0.492495072051132 0.308482149362962 no 1065 0.311184702397098 337 24824909
SGTC_77 0828-0286 12.516 µM 0.491989971476586 0.308664255747026 no 1066 0.311363216512431 315 745345
SGTC_1883 5-benzylidenerhodanine 20 µM 0.491253051394071 0.308930025570811 no 1067 0.311623740527285 330 1273210
SGTC_2627 acetyl isogambogic acid 100 µM 0.490382944821532 0.30924395785587 no 1068 0.311931471516761 342 6857789 A caspase activator and apoptosis inducer.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.488544374723727 0.3099077673816 no 1069 0.31258215117867 323 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1560 lithocholic acid 53.1 µM 0.488142841907243 0.310052822039719 no 1070 0.312724333613671 340 9903 A bile acid which acts as a detergent.
SGTC_1219 1469-0211 33.1 µM 0.48649694451381 0.310647715077681 no 1071 0.313307435587885 370 6822282
SGTC_1684 st024538 14.6195 µM 0.486387778734127 0.310687189486469 no 1072 0.313346126936388 337 6732859
SGTC_3171 9103192 49.47 µM 0.482952524482143 0.311930490884505 no 1073 0.314564723030551 351 13018434
SGTC_2513 baicalein 25.65 µM 0.482576729812393 0.31206663050891 no 1074 0.314698152567156 341 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1338 1486-1223 76 µM 0.48200304122403 0.312274510927384 no 1075 0.314901892921335 347 3444526
SGTC_2714 st079313 56.9 µM 0.48136305199767 0.312506486421372 no 1076 0.315129245839874 333 2939799
SGTC_2744 captopril 92.04 µM 0.480636610054732 0.312769888290227 no 1077 0.315387395526556 318 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2876 9059903 25.97 µM 0.480506006805911 0.312817254099246 no 1078 0.315433816490561 329 6916095
SGTC_268 camptothecin 39.6153 µM 0.480034989956816 0.312988103190927 no 1079 0.315601256552872 342 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1939 st074455 53.6 µM 0.478550069364359 0.313526982240917 no 1080 0.316129373266727 367 1644229
SGTC_2311 7694451 200 µM 0.478545487869104 0.313528645486557 no 1081 0.316131003271427 376 2163142
SGTC_3244 9134489 49.47 µM 0.476491528829905 0.314274687063905 no 1082 0.316862120501618 367 16584271
SGTC_147 4466-0538 29.23 µM 0.475387489386108 0.314676011649505 no 1083 0.317255404964288 328 6742687 YHR072W ERG7
SGTC_269 exalamide 29 µM 0.47461946435895 0.314955322304159 no 1084 0.317529115091446 338 3316 A derivative of salicylamide.
SGTC_3170 9103054 49.47 µM 0.474618612469207 0.314955632173025 no 1085 0.317529418744859 359 16432970
SGTC_981 1488-1094 54.9 µM 0.471851668249871 0.315962774768514 no 1086 0.318516334114317 338 3449522
SGTC_1186 1319-0216 26 µM 0.470595885362991 0.316420320000398 no 1087 0.318964673257961 339 4565136
SGTC_487 nimodipine 119 µM 0.470124266746611 0.316592227177783 no 1088 0.319133118850015 358 4497 L-type voltage-gated calcium channels inhibitor
SGTC_868 0527-0199 213 µM 0.469496496795715 0.316821113715345 no 1089 0.319357394154641 335 2849450
SGTC_556 4058-0063 51.5 µM 0.468369152490069 0.317232322365913 no 1090 0.31976031188666 362 6615692
SGTC_1022 4477-0945 21.3 µM 0.467497684633713 0.317550352588976 no 1091 0.320071924122539 348 4648966
SGTC_718 1130-0073 349 µM 0.467351558309186 0.317603692577031 no 1092 0.320124187195607 355 6740020
SGTC_124 0136-0217 7.121 µM 0.466446439240023 0.317934169399773 no 1093 0.320447988673599 324 3976905
SGTC_3010 9080089 71.4286 µM 0.466247019285379 0.318007001066843 no 1094 0.32051934847859 354 17027233
SGTC_2973 9094665 17.96 µM 0.465535516538737 0.318266911701142 no 1095 0.320774004421698 370 25237061 YIL048W NEO1
SGTC_1204 4049-0315 18.3 µM 0.460604968579363 0.320070484989005 no 1096 0.322541023121583 337 588402
SGTC_1932 st074806 40.9 µM 0.46034222218796 0.320166716425108 no 1097 0.322635299698918 399 17251235
SGTC_3237 9133362 49.47 µM 0.459434989925474 0.320499085181632 no 1098 0.322960913223216 382 43845137
SGTC_2129 girgensonine 121.053 µM 0.458334134640932 0.320902582007757 no 1099 0.323356202006322 362 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2079 5212404 121 µM 0.457807233571359 0.321095782135004 no 1100 0.323545469228224 336 758462
SGTC_1051 3253-3903 78 µM 0.456335101114404 0.32163582920416 no 1101 0.324074513251892 349 5509239
SGTC_2591 skatole 100 µM 0.455617960130747 0.321899046753402 no 1102 0.324332362886333 378 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2496 diffractaic acid 79.83 µM 0.455569534762241 0.321916823897133 no 1103 0.32434977737348 352 94870 An apoptosis inducer which activates caspases.
SGTC_532 1548-0774 215 µM 0.454118528229374 0.322449683035626 no 1104 0.324871759113214 379 5932993
SGTC_1242 0402-0103 60.1 µM 0.453376967489683 0.322722150454891 no 1105 0.325138659368288 344 432868
SGTC_2283 7944793 200 µM 0.452682145471932 0.322977531335004 no 1106 0.325388819010894 356 2970533
SGTC_2738 aclarubicin 5.55 µM 0.452469623150898 0.323055660300515 no 1107 0.325465350021246 326 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_289 k017-0060 526 µM 0.452225583340496 0.323145385579428 no 1108 0.325553239812467 358 5512909
SGTC_12 0849-0099 9.267 µM 0.448653417867911 0.324459926833357 no 1109 0.32684084642759 373 6071388
SGTC_2084 5306078 60.6385 µM 0.446381219469823 0.325297226822213 no 1110 0.327660948260181 391 679340
SGTC_285 1486-1325 46 µM 0.44628164029892 0.325333941742226 no 1111 0.327696908310505 362 22310230
SGTC_465 cgp-37157 41 µM 0.446063599467214 0.325414339491241 no 1112 0.327775652839995 350 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.444966485236959 0.325818999405371 no 1113 0.328171987194532 356 136420
SGTC_1454 4239-0054 42.6 µM 0.444349454251541 0.326046675512671 no 1114 0.32839497572587 376 1340767
SGTC_2889 9059656 51.95 µM 0.444088312896561 0.326143052689058 no 1115 0.328489367894184 359 3949838
SGTC_1915 st067105 30.6 µM 0.443346527174559 0.326416880444326 no 1116 0.328757553497651 359 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1794 st048918 76.9 µM 0.443012691515176 0.326540145319697 no 1117 0.328878277408999 361 672303
SGTC_1720 st037298 9.481 µM 0.441146046370449 0.327229730740887 no 1118 0.329553635006146 383 597396
SGTC_2413 inermin 26.06 µM 0.440895078453139 0.327322489623938 no 1119 0.329644478393695 395 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1107 amlodipine 47 µM 0.440508254526447 0.32746548238932 no 1120 0.329784517554294 338 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3139 9095020 49.47 µM 0.439400750578485 0.327875020614793 no 1121 0.330185591378284 331 25236292
SGTC_1617 st002906 78 µM 0.438721158886861 0.328126425911704 no 1122 0.330431796829423 378 5150859
SGTC_2261 9010538 184.68 µM 0.436437271613869 0.328971887696148 no 1123 0.331259750931635 374 6457250
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.435630008760265 0.329270934346009 no 1124 0.331552597293523 380 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_211 3455-0679 143.504 µM 0.434718253194835 0.329608821207825 no 1125 0.331883473765861 347 748649
SGTC_1744 st037937 38.9 µM 0.432618125775675 0.330387634960502 no 1126 0.332646109546777 344 1016152
SGTC_3062 9077494 49.47 µM 0.431148255353626 0.330933161073753 no 1127 0.333180287685284 333 16459633
SGTC_1215 3852-0577 11.2 µM 0.428969860392424 0.331742308600447 no 1128 0.333972579310181 346 2884876
SGTC_1311 1190-0148 100 µM 0.428012070797961 0.332098320820598 no 1129 0.334321166123784 380 1961333
SGTC_1690 st023502 41.2 µM 0.427846102853184 0.332160026842674 no 1130 0.334381584571262 396 24207482
SGTC_1130 3454-2858 15.9 µM 0.42768959829172 0.332218218597127 no 1131 0.334438561928944 410 715628 YIL048W NEO1
SGTC_2588 indole-3-carbinol 100 µM 0.427453483564428 0.332306018775238 no 1132 0.334524529536853 395 3712 Induces cell cycle arrest.
SGTC_1170 0310-0127 64.8 µM 0.423372449130394 0.333825018075106 no 1133 0.336011771385872 396 774975
SGTC_2859 9028643 45.46 µM 0.420002776702203 0.335081298938621 no 1134 0.337241712623173 347 17151580
SGTC_1570 verbenone 133 µM 0.417704162143021 0.335939328968985 no 1135 0.338081714415614 391 29025 A natural terpanoid with antifungal properties.
SGTC_2748 diazoxide 86.69 µM 0.416736613167301 0.336300753171789 no 1136 0.33843553538647 364 3019 A potassium channel activatior.
SGTC_2894 9048625 32.47 µM 0.415733263038738 0.336675710611531 no 1137 0.338802599114425 406 4092861
SGTC_331 k048-0133 24.5 µM 0.41492447699516 0.336978076644228 no 1138 0.339098595374969 361 6813582
SGTC_3196 9111891 49.47 µM 0.413832822508225 0.337386360595264 no 1139 0.339498272204871 379 18891510
SGTC_1875 nocodazole 6 µM 0.413651883808012 0.337454051043923 no 1140 0.339564534988011 363 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_867 0518-0118 155 µM 0.413558418169616 0.337489019261562 no 1141 0.339598765613346 385 6848158
SGTC_3056 9094900 49.47 µM 0.413274554696015 0.337595229457521 no 1142 0.339702735183765 358 25236784
SGTC_45 0kpi-0036 14.9 µM 0.412746902063875 0.337792690036509 no 1143 0.339896028865588 385 2795021
SGTC_603 3794-0023 45.9 µM 0.412662789482771 0.337824171158745 no 1144 0.339926845510846 367 3802260
SGTC_129 0088-0017 176.636 µM 0.412637459568752 0.33783365170025 no 1145 0.339936125937057 375 182446
SGTC_101 0490-5701 117.494 µM 0.412288005823443 0.337964456591957 no 1146 0.340064169420065 385 4661669
SGTC_595 3909-8003 73.7 µM 0.411864219427708 0.338123111374143 no 1147 0.34021947391044 376 699517
SGTC_1609 st001574 46.4 µM 0.410323106222261 0.338700306945543 no 1148 0.340784472186376 412 3960012
SGTC_2785 7756463 72.73 µM 0.409692039437981 0.338936770846832 no 1149 0.34101593518876 384 2201551
SGTC_2215 7188065 200 µM 0.409246092198388 0.339103907806151 no 1150 0.341179536043727 390 940217
SGTC_1559 coumarin 343 70.1 µM 0.409173693928438 0.33913104500653 no 1151 0.341206098996755 367 108770 A hepatotoxic, DNA x-linker.
SGTC_1887 st057648 70.8 µM 0.408335544104515 0.339445271249024 no 1152 0.341513673746138 384 688672
SGTC_2941 9056145 11.23 µM 0.407846537972768 0.339628653500264 no 1153 0.341693172333556 397 2119517
SGTC_1471 k673-0312 37 µM 0.407092412933323 0.339911532447088 no 1154 0.341970057802007 360 24099884
SGTC_2321 7390090 138.78 µM 0.406889597390596 0.339987625735914 no 1155 0.342044538316122 375 649046
SGTC_3067 9117431 49.47 µM 0.405061943850516 0.340673627122496 no 1156 0.342715989550863 388 17150885
SGTC_340 k038-0059 454 µM 0.404243162990446 0.340981123946499 no 1157 0.343016958191945 386 23733424
SGTC_3332 9141069 11.198 µM 0.402199071545866 0.341749252453888 no 1158 0.343768762735496 365 17332883
SGTC_2303 7774051 200 µM 0.40180495938191 0.341897427383384 no 1159 0.343913786003715 396 2953184
SGTC_2004 4023728 41.89 µM 0.401687195631438 0.341941707921171 no 1160 0.343957124530948 404 360084 YDR527W RBA50
SGTC_2558 carylophyllene oxide 100 µM 0.401211009502709 0.342120781601074 no 1161 0.344132387858608 379 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3085 9117376 49.47 µM 0.399130153675768 0.342903720630294 no 1162 0.344898652512641 375 16480349
SGTC_1506 4226-2149 212 µM 0.398853255158691 0.343007956929904 no 1163 0.345000667052292 372 991114
SGTC_2567 aureobasidin a 60 nM 0.398742324434364 0.343049719293691 no 1164 0.345041539146179 385 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_468 gf-109203x 121 µM 0.398473010078415 0.343151116711431 no 1165 0.345140774737641 373 2396 A protein kinase C inhibitor.
SGTC_2340 7987427 183.45 µM 0.396900962350666 0.343743221139807 no 1166 0.345720247259282 356 2239331
SGTC_1998 st075797 76.8 µM 0.396594936345621 0.343858529044025 no 1167 0.34583309360015 392 24208315
SGTC_2650 prasterone 100 µM 0.396504143115682 0.343892741928067 no 1168 0.345866576016651 361 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1075 aripiprazole 15.2 µM 0.394923372702967 0.34448861560956 no 1169 0.346449720101738 355 60795 An atypical antipschotic. YIL048W NEO1
SGTC_920 mycophenolic acid 780.421 nM 0.393610320817469 0.344983866076854 no 1170 0.346934380106101 353 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_535 2293-4129 48.2 µM 0.393282551827205 0.345107533846029 no 1171 0.347055401879657 406 396118 YIL048W NEO1
SGTC_1101 ebselen 5.29 µM 0.393149961277692 0.345157565175062 no 1172 0.347104362570994 398 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1713 st033146 12.748 µM 0.390360952825498 0.34621058748045 no 1173 0.348134828607514 390 674619
SGTC_210 3551-0445 56.827 µM 0.388904998788242 0.346760773057526 no 1174 0.348673212103691 377 2865180 YOR207C RET1
SGTC_574 1315-0397 40 µM 0.387436011703566 0.347316211349589 no 1175 0.349216724005122 370 6794277
SGTC_92 0063-0024 660.874 µM 0.387287125143461 0.347372525134871 no 1176 0.349271827968712 399 3594437
SGTC_1092 toremifene 6.32 µM 0.38635650857383 0.347724591179045 no 1177 0.349616327669421 401 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_518 1021-0119 62.6 µM 0.386327501829758 0.347735566972827 no 1178 0.349627067504696 373 1097762
SGTC_727 3032-0951 202 µM 0.386019287716373 0.347852199268036 no 1179 0.34974119215021 395 3652836
SGTC_384 k007-0144 5.16 µM 0.385961090265407 0.347874223569221 no 1180 0.349762742861222 377 6824886
SGTC_1545 lovastatin 49.4 µM 0.384454566140597 0.34844453248843 no 1181 0.350320782068059 361 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_395 anisomycin 6.25 µM 0.384382436206066 0.348471846564239 no 1182 0.350347508200062 393 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3328 9140624 29.0385 µM 0.382254812739011 0.349277885290549 no 1183 0.351136184219363 390 4904392
SGTC_631 k072-0230 41.5 µM 0.38082138407753 0.349821315847817 no 1184 0.351667895295681 360 5773147
SGTC_3206 9114350 49.47 µM 0.380523212213706 0.349934395203159 no 1185 0.351778534645285 393 17087243
SGTC_1273 0849-0096 14.1 µM 0.380159346442104 0.350072406492762 no 1186 0.351913567316477 398 5286025
SGTC_673 1082-0474 110 µM 0.379155899780986 0.350453108117243 no 1187 0.352286048860174 378 3098046
SGTC_458 nppb 133 µM 0.378944684255382 0.350533261173739 no 1188 0.352364470582838 365 4549 A chloride channel blocker.
SGTC_2690 usnic acid 100 µM 0.378852049424983 0.35056841677255 no 1189 0.352398866734556 402 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_451 chloral hydrate 100 µM 0.378622860504385 0.350655401151901 no 1190 0.352483971844425 393 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_679 0422-0091 41.4 µM 0.378618432404287 0.350657081831807 no 1191 0.352485616211067 397 627384 YHR062C RPP1
SGTC_1404 3909-7820 48.3 µM 0.378513193087316 0.350697026144333 no 1192 0.35252469744476 379 23741373
SGTC_123 0083-0120 66.675 µM 0.378411289200005 0.350735706044361 no 1193 0.352562541530794 375 16001701
SGTC_1778 st046819 58.9 µM 0.37783193813015 0.350955641096317 no 1194 0.35277772308491 435 671715
SGTC_3247 9135149 49.47 µM 0.377611489197175 0.351039341726352 no 1195 0.352859614215562 404 8934436 YOR116C RPO31
SGTC_549 1661-1316 519 µM 0.375720046053593 0.351757786497613 no 1196 0.353562516703245 397 2857282
SGTC_2671 danthron 100 µM 0.37565675104893 0.351781837612655 no 1197 0.353586047192398 372 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2830 7992007 71.43 µM 0.375557136337846 0.351819690851295 no 1198 0.353623080993306 356 1952075
SGTC_2134 5324836 1.464 µM 0.375507305880457 0.351838626800433 no 1199 0.353641607002246 393 699272
SGTC_1423 4048-0112 5.59 µM 0.374767480799959 0.352119809115204 no 1200 0.353916700545142 394 X1423
SGTC_425 3825-7017 13.1 µM 0.373532332445233 0.352589427087675 no 1201 0.354376143001494 435 3397440
SGTC_600 1495-0418 41.6 µM 0.373437464270602 0.352625506390019 no 1202 0.354411440223859 374 5377768
SGTC_730 1436-0052 41.2 µM 0.373275037179546 0.352687282092405 no 1203 0.354471876725338 360 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1605 st000082 49.1 µM 0.372813719399091 0.352862755715458 no 1204 0.354643545611177 404 1114022
SGTC_3251 9135047 49.47 µM 0.370600444819957 0.353705064191592 no 1205 0.355467575351037 387 17682963
SGTC_1846 st056244 14.8 µM 0.367614353742613 0.354842619623093 no 1206 0.356580405228181 393 5393182
SGTC_2803 7707263 71.43 µM 0.366575335551572 0.355238739323473 no 1207 0.356967904362416 387 2199229
SGTC_1627 st003713 25.6 µM 0.366570083485613 0.355240742041186 no 1208 0.356969863482051 372 16195070 YER133W GLC7
SGTC_1397 3532-0190 20.1 µM 0.366251382962713 0.355362276400418 no 1209 0.357088751843366 356 5322280
SGTC_1922 5578187 25 µM 0.364608578721829 0.355988982164139 no 1210 0.35770180509181 373 1350412
SGTC_2285 7945142 200 µM 0.364011826147168 0.356216731020136 no 1211 0.357924589176384 401 2970608
SGTC_3187 9109394 49.47 µM 0.362847983907531 0.356661055501095 no 1212 0.358359222549818 377 17098090
SGTC_558 k064-0027 21.3 µM 0.362438679175663 0.356817363605822 no 1213 0.358512119828092 381 5088526
SGTC_1662 st014054 52 µM 0.362217348268408 0.356901896991891 no 1214 0.358594808248238 406 2838777
SGTC_579 4491-1009 110 µM 0.361807887568282 0.357058301713235 no 1215 0.358747798747213 419 1271041
SGTC_1449 4112-4002 201 µM 0.360374754579718 0.357605915132839 no 1216 0.359283451525322 371 2059539
SGTC_122 0236-0016 402.397 µM 0.359621706862958 0.357893779269798 no 1217 0.359565024226525 396 6808838
SGTC_1447 4239-0816 81.9 µM 0.357350818375455 0.358762350331544 no 1218 0.360414595227528 370 1341554
SGTC_1737 st035557 69.7 µM 0.356611776701181 0.35904517738039 no 1219 0.360691229947561 380 5716916
SGTC_3248 9135562 49.47 µM 0.356000211167692 0.359279278476288 no 1220 0.36092020351946 362 17650701
SGTC_3207 9114163 49.47 µM 0.355235145304093 0.359572212334175 no 1221 0.361206718666865 425 849233
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.355175005579014 0.359595242560829 no 1222 0.361229244138691 381 88881 An O-methylated flavonoid and antioxidant.
SGTC_217 ketoconazole 989 nM 0.355093976876391 0.359626272930171 no 1223 0.361259594385768 381 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_297 0986-0032 24 µM 0.353963636602764 0.360059239127508 no 1224 0.361683067520727 399 2847425
SGTC_347 4534-1311 26.2 µM 0.353781820991089 0.360128898666198 no 1225 0.36175119915025 381 2862016
SGTC_2866 9034245 58.44 µM 0.353572503253762 0.360209100924923 no 1226 0.361829642057932 427 6462273
SGTC_1182 1222-0449 220 µM 0.352391721115736 0.360661644987534 no 1227 0.36227225495074 383 658318
SGTC_967 1306-0166 352 µM 0.352135107800642 0.360760019906231 no 1228 0.362368470121853 405 4437607
SGTC_735 3076-0345 636 µM 0.350377125995441 0.361434204804537 no 1229 0.363027845277397 379 2888990
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.348925055719935 0.361991397584608 no 1230 0.363572787099393 437 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_953 1188-0045 9.7 µM 0.348694166069346 0.362080022251531 no 1231 0.36365946225491 402 6144426
SGTC_2789 5281112 71.43 µM 0.348557198798601 0.362132599253755 no 1232 0.363710882580331 381 765948
SGTC_1919 st067113 52.3 µM 0.348339810982926 0.362216052264787 no 1233 0.363792499469221 391 1268243
SGTC_303 1348-1668 34.2 µM 0.34770636211197 0.362459264293608 no 1234 0.364030359098182 394 5380509
SGTC_2882 9058044 58.44 µM 0.347558499008318 0.362516044172918 no 1235 0.364085889140814 371 18076804
SGTC_2150 5556613 200 µM 0.347320789043669 0.362607331856928 no 1236 0.36417516718628 395 743190
SGTC_2763 lisinopril 49.32 µM 0.345241575665801 0.36340614396131 no 1237 0.364956382574575 418 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_630 4356-0227 183 µM 0.344580202583498 0.363660361366574 no 1238 0.365204995654411 402 779312
SGTC_3123 9126162 49.47 µM 0.343733489283735 0.363985907136723 no 1239 0.365523361640753 357 25239884
SGTC_2054 5233173 129 µM 0.343692450757212 0.364001688195882 no 1240 0.365538794569557 366 6889
SGTC_3259 9138485 49.47 µM 0.343484007074555 0.36408184721907 no 1241 0.365617185162114 370 17646153
SGTC_3135 9127742 49.47 µM 0.339776439804677 0.365508618503922 no 1242 0.367012445884029 389 3643468
SGTC_3065 9113888 49.47 µM 0.33968159525565 0.36554514174997 no 1243 0.367048161670501 402 16648368
SGTC_2911 7942208 15.64 µM 0.336776700797262 0.366664363056482 no 1244 0.368142619092842 378 1243384
SGTC_927 2425-1185 123 µM 0.336353145193211 0.366827649003463 no 1245 0.368302288949627 419 730375
SGTC_2855 9016525 58.44 µM 0.33612670510029 0.366914954360098 no 1246 0.368387660528113 405 43811474
SGTC_3329 9141233 27.5565 µM 0.33547224481341 0.367167324194043 no 1247 0.368634439161517 404 4909101 YNL103W MET4
SGTC_3094 9117742 49.47 µM 0.334666424412275 0.367478139630848 no 1248 0.368938365876612 417 17149698
SGTC_609 0986-0026 86.3 µM 0.331055625964538 0.368871935355991 no 1249 0.370301234386887 407 2848610
SGTC_2463 5473429 200 µM 0.330194438426976 0.369204615965463 no 1250 0.370626524447239 411 5399405
SGTC_1795 st049545 62.3 µM 0.328670417816266 0.369793591967852 no 1251 0.371202408174783 382 5291882
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.327814086592133 0.370124665600673 no 1252 0.371526117897554 432 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3041 9091929 49.47 µM 0.326953786696179 0.370457370525852 no 1253 0.371851419370998 396 25236887
SGTC_749 1000-0129 128 µM 0.32635457642037 0.370689161193072 no 1254 0.372078050238047 416 708470
SGTC_610 4215-0184 155 µM 0.324969576875714 0.371225095822802 no 1255 0.37260204861721 417 5605015
SGTC_1629 st005085 44.9 µM 0.324563196389098 0.37138239485867 no 1256 0.372755842723787 425 24207091
SGTC_1971 st069429 63.5 µM 0.319776725144393 0.373236720263125 no 1257 0.374568796285294 411 1246522 YGL099W LSG1
SGTC_2840 9008771 71.43 µM 0.319685700831895 0.373272012584385 no 1258 0.374603300244718 373 2992978
SGTC_3352 9151559 45.5865 µM 0.319648231179228 0.373286540781336 no 1259 0.37461750389971 384 17159339
SGTC_91 0417-1751 58.384 µM 0.318367383884735 0.37378327493006 no 1260 0.37510313802002 414 6795624
SGTC_1239 0337-0584 35.4 µM 0.318330459007396 0.373797598133244 no 1261 0.375117141053109 411 914301 YML130C ERO1
SGTC_1196 1588-0294 184 µM 0.316796352293039 0.374392833747615 no 1262 0.375699066106909 423 6144269
SGTC_2518 prenyletin 46.28 µM 0.315954744210717 0.374719506211614 no 1263 0.376018429348048 386 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1514 1189-1591 158 µM 0.315661370750475 0.374833401065848 no 1264 0.376129775129188 434 767698 YMR146C TIF34
SGTC_1173 0443-0020 122 µM 0.314558995032954 0.375261468178625 no 1265 0.376548258469316 415 5331295
SGTC_1680 diphenhydramine 100 µM 0.314404463580289 0.375321487082955 no 1266 0.376606933234491 426 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_220 paclitaxel 373.376 µM 0.313898351103918 0.375518078650589 no 1267 0.376799121383262 418 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_855 0428-0020 25 µM 0.312928124942312 0.375895038353638 no 1268 0.377167634646379 394 6812414
SGTC_1616 st002734 56.1 µM 0.31114592620917 0.376587780296495 no 1269 0.377844844309247 407 4026101
SGTC_809 3998-0021 90 µM 0.310461885686683 0.376853773063891 no 1270 0.378104869645781 438 715485
SGTC_955 1216-0110 33 µM 0.310434226579691 0.376864529684211 no 1271 0.378115384905509 407 3619719
SGTC_191 3914-0123 66.505 µM 0.310406226923125 0.376875418841533 no 1272 0.378126029725125 425 3144412
SGTC_2909 7941780 10.49 µM 0.309756441738503 0.37712814990204 no 1273 0.378373088943158 403 1243215
SGTC_2984 9022109 38.96 µM 0.307585803071783 0.377972791273618 no 1274 0.37919876216329 425 6459207
SGTC_2237 6667747 47.222 µM 0.307434162325467 0.37803181974972 no 1275 0.379256464316114 440 729940 YDL015C TSC13
SGTC_1257 0669-0121 16 µM 0.305578864056615 0.37875425308535 no 1276 0.379962657597351 409 4307855
SGTC_2275 7947463 200 µM 0.30498232180209 0.378986630442505 no 1277 0.380189808237322 410 1225414
SGTC_3231 9132313 49.47 µM 0.304439457704757 0.379198136004396 no 1278 0.380396555294471 409 4905967
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.303821429844075 0.379438970181605 no 1279 0.380631969685516 393 16725076
SGTC_2629 bisabolol 100 µM 0.303552256405855 0.379543876789647 no 1280 0.38073451497384 446 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_792 4534-1957 155 µM 0.303244256494731 0.379663926355001 no 1281 0.380851862014817 401 1717904
SGTC_1534 6-azauridine 81.6 µM 0.30019400822901 0.380853450551965 no 1282 0.382014587590096 410 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2451 5856223 45.7 µM 0.29909697055668 0.38128154527933 no 1283 0.382433028846228 400 2179896
SGTC_2773 thioridazine 9.09 µM 0.298348221510615 0.381573811527482 no 1284 0.382718701825138 423 5452 An antipsychotic.
SGTC_1718 roemerine 11.9335 µM 0.297985259049599 0.381715514388518 no 1285 0.382857207205885 396 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2491 paeonol 100 µM 0.295766052420485 0.382582250929181 no 1286 0.383704374965986 413 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1891 st059073 26.2 µM 0.295516549100667 0.382679734185267 no 1287 0.383799656097062 444 688754
SGTC_939 1165-0479 45.3 µM 0.295403972067081 0.382723721508194 no 1288 0.383842649677561 430 1377347
SGTC_3011 9081274 71.4286 µM 0.293296179254916 0.383547579986706 no 1289 0.384647886909914 400 6625322
SGTC_3353 9151644 39.2805 µM 0.293246620998928 0.3835669568341 no 1290 0.384666825587723 450 4909158
SGTC_2029 5175081 200 µM 0.292592683431823 0.383822667994302 no 1291 0.384916753461898 386 1380876
SGTC_3059 1327-0034 3 µM 0.290446596173703 0.384662213838564 no 1292 0.385737300324993 389 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1764 st044502 93.5 µM 0.290318623640979 0.384712293621205 no 1293 0.385786246248603 392 8407
SGTC_2616 abietic acid 100 µM 0.289473906477048 0.385042906933577 no 1294 0.386109372581865 435 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1968 st069590 43.6 µM 0.289143082698601 0.38517241063334 no 1295 0.38623594284608 422 6384066
SGTC_1210 3013-0140 750 nM 0.288005058389806 0.385617997370083 no 1296 0.386671433308463 424 905973
SGTC_2315 7733312 200 µM 0.287342624398953 0.385877439077543 no 1297 0.386924994263256 384 726316
SGTC_2467 5474540 200 µM 0.285008357225981 0.386792059025204 no 1298 0.387818869606958 388 5413519
SGTC_2647 atorvastatin 60.16 µM 0.284919529588689 0.386826876208063 no 1299 0.387852896700437 426 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2002 4023503 131 µM 0.284294754342404 0.387071790956774 no 1300 0.38809225290028 443 4736863 YCR052W RSC6
SGTC_2838 9002687 71.43 µM 0.283724989700421 0.387295180502824 no 1301 0.388310571184513 423 6457060
SGTC_2373 9071805 200 µM 0.283248933613657 0.387481858046111 no 1302 0.388493009972054 425 10149009
SGTC_412 gemfibrozil 100 µM 0.282428645685765 0.387803581446422 no 1303 0.388807426289895 418 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1731 st035964 63 µM 0.282142154346191 0.387915963774184 no 1304 0.388917255579478 421 6739575
SGTC_695 3505-6186 243 µM 0.281549020007377 0.388148663177197 no 1305 0.389144667704502 419 1819379
SGTC_3161 9100388 49.47 µM 0.281205179838759 0.388283577491599 no 1306 0.3892765159821 420 25236368
SGTC_2060 5238662 140 µM 0.28117738554671 0.388294483868372 no 1307 0.389287174484016 400 790130
SGTC_2596 sinensetin 100 µM 0.280244224992007 0.388660703669811 no 1308 0.389645069404699 403 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1957 st077035 62.4 µM 0.279086816893378 0.389115067131348 no 1309 0.390089099969595 444 705593
SGTC_3271 9137798 49.47 µM 0.278620641568506 0.389298116367482 no 1310 0.390267985043477 407 6498326
SGTC_2037 5169046 200 µM 0.278159496627917 0.389479214536668 no 1311 0.3904449626737 398 5718022
SGTC_1094 duloxetine 25.4 µM 0.278031294499713 0.389529565599565 no 1312 0.390494167961171 403 60834 A selective serotonin reuptake inhibitor.
SGTC_1308 1187-1617 41.4 µM 0.277591874954886 0.389702160585261 no 1313 0.390662834978686 426 2882570
SGTC_1078 idebenone 36.1 µM 0.277011754718896 0.389930053229531 no 1314 0.390885540126861 423 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2903 5923464 63.88 µM 0.276524580907386 0.390121462323065 no 1315 0.391072591277111 426 2876576
SGTC_1552 6-methylflavone 10.6 µM 0.276030800200566 0.390315494432931 no 1316 0.391262204870354 445 689013
SGTC_1393 3470-5649 58.2 µM 0.275718159912039 0.390438361186029 no 1317 0.39138227324754 443 4108395
SGTC_874 0599-0792 117 µM 0.274074139004048 0.391084636565377 no 1318 0.392013823622849 444 765305
SGTC_417 st075190 100 µM 0.27394532655357 0.391135286316126 no 1319 0.392063318950466 453 222757
SGTC_1978 st071761 42 µM 0.273615788789578 0.39126487074544 no 1320 0.392189949593068 402 5147680
SGTC_2870 9038528 12.99 µM 0.273542144512125 0.391293831601095 no 1321 0.392218250254648 426 6463316
SGTC_709 3807-1509 243 µM 0.272506530702984 0.391701153913633 no 1322 0.392616285223634 444 1886677 YPL242C IQG1
SGTC_899 1083-0020 478 µM 0.271418432047183 0.392129247225979 no 1323 0.393034613604838 454 767123
SGTC_1164 k060-0068 93.7 µM 0.269670197716732 0.392817332621044 no 1324 0.393706995072156 408 5963676
SGTC_381 3461-2219 42.7 µM 0.268530326682642 0.393266153664981 no 1325 0.394145567227218 436 2883159
SGTC_666 0272-0154 136 µM 0.267866515113496 0.393527593036226 no 1326 0.394401034569104 422 6870312
SGTC_2056 5235370 200 µM 0.267572437379205 0.393643429657455 no 1327 0.39451422467285 404 5511916
SGTC_3243 9134147 49.47 µM 0.267123231952361 0.393820388928566 no 1328 0.394687140396723 435 24282180
SGTC_3086 9117350 49.47 µM 0.266271350203782 0.394156038064848 no 1329 0.39501511803846 420 2679265
SGTC_197 4544-0043 41.561 µM 0.263390551660738 0.39529167994898 no 1330 0.39612478613288 426 896523
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.262654698211841 0.395581904386545 no 1331 0.396408368317994 423 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2765 myclobutanil 7.74 µM 0.260205473879145 0.396548307558862 no 1332 0.397352641057607 446 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2985 9022375 71.43 µM 0.259769171137766 0.396720528694777 no 1333 0.397520916322291 410 4939335
SGTC_291 SEC14.278 35.5 µM 0.259582607603435 0.396794176794473 no 1334 0.397592876834672 421 1068044
SGTC_1315 1237-0019 3.69 µM 0.258189352667059 0.397344296433031 no 1335 0.398130387383474 438 825140
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.257549887966395 0.397596854282027 no 1336 0.398377154366182 400 3256 An antibiotic and ribosome inhibitor.
SGTC_819 1013-0258 27.7 µM 0.257025525952706 0.397803984137015 no 1337 0.398579533995285 416 5753198
SGTC_2655 perillic acid 100 µM 0.255796931330549 0.39828940782451 no 1338 0.39905382177158 431 5702197 An apoptosis inducer.
SGTC_364 0083-0097 67.7 µM 0.254747640107228 0.398704112558152 no 1339 0.399459009158475 403 5207356
SGTC_3217 9129673 49.47 µM 0.254554708684557 0.398780376088431 no 1340 0.399533522087765 394 17248312
SGTC_287 k060-0039 29.6 µM 0.25375064291412 0.399098255450195 no 1341 0.399844103393138 416 5861974
SGTC_1112 tnp00069 1.16933 µM 0.253475659900995 0.399206982602794 no 1342 0.399950333862578 438 145826
SGTC_3138 9097216 49.47 µM 0.252273590763438 0.399682367495285 no 1343 0.400414799814268 453 25237486
SGTC_2268 7933382 153.85 µM 0.252200644172945 0.399711220636042 no 1344 0.400442990093802 382 935025 YOR257W CDC31
SGTC_1143 3454-2408 5.08 µM 0.251614911971311 0.399942919757857 no 1345 0.400669365651637 424 X1143
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.251299722071662 0.400067614568328 no 1346 0.400791195012593 419 6708784 An antioxidant flavonoid
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.250385411837994 0.400429389798363 no 1347 0.401144655030515 412 16623 A steroid.
SGTC_2207 7258803 200 µM 0.249901892569621 0.400620743768977 no 1348 0.401331609797582 440 3666799
SGTC_178 4092-0806 87.505 µM 0.248491434374836 0.401179072271842 no 1349 0.401877098334925 430 2169044
SGTC_294 k038-0071 157 µM 0.248470512139042 0.401187355840695 no 1350 0.401885191359902 436 24152826
SGTC_989 1501-0895 10.3 µM 0.247916920768726 0.401406550846633 no 1351 0.402099343823966 462 2830112
SGTC_3087 9117406 49.47 µM 0.24791448272755 0.40140751625993 no 1352 0.402100287026059 387 42546093
SGTC_3153 9100258 49.47 µM 0.247623842700968 0.401522607940417 no 1353 0.402212730671179 452 25236848
SGTC_3234 9132280 49.47 µM 0.247610656083631 0.401527829963249 no 1354 0.402217832539413 415 17612295
SGTC_2319 6033012 152.6 µM 0.246900436877005 0.401809109316413 no 1355 0.402492639106715 412 847246
SGTC_3016 9080866 49.47 µM 0.246509513926099 0.401963954436294 no 1356 0.402643920293977 453 17066299
SGTC_971 1315-0384 26.7 µM 0.245883645511181 0.402211893811751 no 1357 0.402886152119114 450 6769120
SGTC_1054 3429-0080 167 µM 0.244784525693561 0.402647408119049 no 1358 0.403311638093751 440 1162877
SGTC_3294 9122953 26.2835 µM 0.24314287045632 0.4032981210851 no 1359 0.403947360831291 454 16459826
SGTC_1896 st058441 89 µM 0.243079650794545 0.403323185217916 no 1360 0.403971847412969 392 688759
SGTC_1710 st031758 61.5 µM 0.242751214969246 0.403453403615257 no 1361 0.404099065008485 448 5394341
SGTC_1160 4092-0570 10.5 µM 0.24109717045124 0.40410936242021 no 1362 0.404739902878828 443 4994975
SGTC_2825 7998094 58.44 µM 0.240197430401214 0.404466293529559 no 1363 0.405088602811889 451 2987815
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.239778930629469 0.40463234147271 no 1364 0.405250820735876 422 5355888
SGTC_645 0845-0943 5.41 µM 0.238796263589659 0.405022301245448 no 1365 0.405631783826779 425 1885106
SGTC_1478 0453-0656 35.7 µM 0.236194912071872 0.406055071180732 no 1366 0.406640713710529 441 5258496
SGTC_2539 epi(13)torulosol 80 µM 0.235279598677663 0.406418618279272 no 1367 0.406995864309157 422 6708597
SGTC_2155 5570423 76 µM 0.234290297028427 0.406811642993985 no 1368 0.407379809085944 445 797402
SGTC_3089 9117425 49.47 µM 0.233812795284951 0.407001376066238 no 1369 0.407565157839704 453 9401657
SGTC_2716 st080858 38.6235 µM 0.232996605724775 0.407325735667388 no 1370 0.407882020742034 439 5296050
SGTC_2946 9065502 71.43 µM 0.229732996690419 0.408623350412856 no 1371 0.4091496264603 425 16489101
SGTC_525 k781-2675 26.7 µM 0.229669480631075 0.408648614461645 no 1372 0.409174305959673 429 3651118 YDL195W SEC31
SGTC_2043 5101342 149 µM 0.228139496520147 0.409257293028691 no 1373 0.409768897909248 430 678451
SGTC_444 curcumin 90.4 µM 0.227506047280616 0.409509364348604 no 1374 0.410015133733714 433 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2963 9082507 9 µM 0.226801120183642 0.409789923156417 no 1375 0.41028919630996 445 16459611
SGTC_264 promethazine 12.5 mM 0.223334939988675 0.411170121564624 no 1376 0.411637417870938 463 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.223323694526848 0.411174601195215 no 1377 0.41164179366555 455 364106
SGTC_1340 1486-1359 257 µM 0.223151981866693 0.411243004385034 no 1378 0.411708611257524 441 4309068
SGTC_2810 7959871 45.46 µM 0.223117732600308 0.411256648192691 no 1379 0.411721938790307 421 2974535
SGTC_1474 0330-0125 5.35 µM 0.221447166183531 0.411922278190209 no 1380 0.412372135295077 456 X1474
SGTC_1888 azatryptophan 97.5 µM 0.221076479842961 0.412070011000337 no 1381 0.412516441768552 406 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2739 tacrine 100.86 µM 0.220459032088144 0.412316115412964 no 1382 0.412756837562869 451 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2112 5488546 200 µM 0.220435550181862 0.412325475591754 no 1383 0.412765980604768 442 600757
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.219796188974233 0.41258035203764 no 1384 0.413014943910084 426 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2249 haloperidol 116.36 µM 0.218907274192474 0.412934772339846 no 1385 0.413361139954432 463 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2017 5132927 60.65 µM 0.217837265415678 0.413361490972413 no 1386 0.41377795405787 432 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3356 9151811 4.48 µM 0.217549641912536 0.413476212468464 no 1387 0.413890012281244 471 1859254 YPR165W RHO1
SGTC_460 trequinsin 123 µM 0.215497525091726 0.414294933481277 no 1388 0.414689720714926 457 5537 A vasodilator.
SGTC_1747 st037496 66.6 µM 0.213973292959995 0.414903288769827 no 1389 0.415283941990958 418 723305
SGTC_2525 harmine 47.85 µM 0.213153851166034 0.415230430863109 no 1390 0.415603481239469 470 5280953 A monoamine oxidase inhibitor
SGTC_1479 0549-0158 134 µM 0.212677346331044 0.415420690806107 no 1391 0.415789318770254 428 5440202
SGTC_2628 lathosterol 100 µM 0.212576065650911 0.415461132945471 no 1392 0.415828820801008 423 6710616
SGTC_2975 9084847 53.72 µM 0.211932796683767 0.415718015985567 no 1393 0.416079731831401 415 27211724
SGTC_1476 4112-3294 3.34 µM 0.211224428649745 0.416000937357348 no 1394 0.416356074727798 458 704369
SGTC_1829 berberine 14.4 µM 0.210711399626551 0.416205867747367 no 1395 0.416556239351186 453 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2136 5328288 199.296 µM 0.210524982540794 0.416280338042445 no 1396 0.416628977647234 435 262395
SGTC_1358 1509-0022 2.48 µM 0.209733789228279 0.416596439051446 no 1397 0.416937726011622 420 3258434
SGTC_862 0452-0056 10.2 µM 0.209174726071094 0.416819830942378 no 1398 0.417155920837536 443 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2246 7293507 91.5585 µM 0.208616151593508 0.417043054392989 no 1399 0.417373950422557 472 887656
SGTC_2555 cholic acid 100 µM 0.207965694081205 0.417303030817777 no 1400 0.417627876927882 438 6708657 Influences liver metabolism.
SGTC_1377 2944-0135 198 µM 0.207405785388426 0.417526845435021 no 1401 0.417846482374836 422 1894137
SGTC_2396 5342950 42.78 µM 0.204866456790324 0.418542236124282 no 1402 0.418838231475864 453 1886677
SGTC_2847 9005661 71.43 µM 0.204355479189913 0.418746624441455 no 1403 0.419037859226746 460 2991449
SGTC_998 3996-0085 177 µM 0.204263266971012 0.418783511175645 no 1404 0.419073886741827 444 715391
SGTC_644 1498-1197 63.3 µM 0.204008330820966 0.418885494455987 no 1405 0.41917349438236 447 6741615
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.203305714414197 0.419166593522524 no 1406 0.419448044671459 480 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2864 9034755 47.6 µM 0.202519453648816 0.419481205504203 no 1407 0.419755325839021 435 4930451
SGTC_2460 5552655 174.22 µM 0.20246915762329 0.419501332556263 no 1408 0.419774983862084 426 5401989
SGTC_544 k015-0020 52.4 µM 0.200799213779091 0.42016971629433 no 1409 0.42042778886116 450 3008304
SGTC_2820 7989630 71.43 µM 0.199512309448442 0.420684948274264 no 1410 0.420931007681387 453 2984098
SGTC_2922 7999257 32.47 µM 0.198736563449177 0.420995595849302 no 1411 0.421234410488236 469 2988377
SGTC_2776 terbinafine 19.92 µM 0.198647930871687 0.421031091910308 no 1412 0.421269078646755 434 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.198245686728791 0.421192192915282 no 1413 0.42142642195854 438 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2707 st078556 66.6 µM 0.197837008868976 0.421355884172972 no 1414 0.421586294756977 461 17250899
SGTC_2294 7971431 200 µM 0.19608712735186 0.422056932635946 no 1415 0.422270985780628 475 5741572
SGTC_1962 st076595 64.5 µM 0.195635518654495 0.422237899127408 no 1416 0.422447728784297 443 279619
SGTC_2405 ticlatone 3.52 µM 0.195385244655852 0.422338194807792 no 1417 0.422545683532783 382 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_690 glyoxal 20.3 µM 0.195368392439787 0.422344948405024 no 1418 0.422552279494374 458 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_247 mechlorethamine 29.705 µM 0.194342178033227 0.422756251144465 no 1419 0.422953980928155 449 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1451 4152-0210 104 µM 0.192526559247881 0.423484150139194 no 1420 0.423664882884073 476 659563
SGTC_1496 4469-0713 57.4 µM 0.191613196766396 0.423850424832505 no 1421 0.424022602269174 464 746691
SGTC_2110 5483698 200 µM 0.191166700145842 0.424029501928014 no 1422 0.424197495947025 435 2848765 YHR062C RPP1
SGTC_1941 st076221 61.8 µM 0.190706203581124 0.424214210436009 no 1423 0.424377889070687 433 2828568
SGTC_622 1348-1566 26.3 µM 0.189833149139262 0.424564444564924 no 1424 0.424719939464665 467 7340407
SGTC_2322 7413319 38.22 µM 0.189803219592106 0.42457645214625 no 1425 0.424731666444863 460 1840400
SGTC_890 0929-0006 47.2 µM 0.189664614270134 0.424632060805391 no 1426 0.424785975581256 446 1378169
SGTC_3268 9137683 49.47 µM 0.188641187319247 0.425042707563163 no 1427 0.425187024754149 496 1953228
SGTC_88 0180-0332 8.668 µM 0.188297652513963 0.425180568051876 no 1428 0.425321662732276 426 3101745
SGTC_2130 NSC 7 2.4545 µM 0.188284798815379 0.425185726417723 no 1429 0.425326700516117 478 21448
SGTC_3017 9080681 49.47 µM 0.186653819801957 0.42584036433324 no 1430 0.425966033054979 469 16451914
SGTC_516 3992-2719 87.3 µM 0.186225973205345 0.42601212615883 no 1431 0.426133778270529 425 5350887 YDR037W KRS1
SGTC_2997 9067075 71.4286 µM 0.185920303586938 0.426134847833253 no 1432 0.426253629916801 475 27209819
SGTC_244 nsc-207895 1.295 µM 0.181826312434672 0.427779207540699 no 1433 0.427859517189045 455 42640
SGTC_1988 st071872 53.4 µM 0.176404640693627 0.429958760138202 no 1434 0.429988029545578 476 16414116
SGTC_3282 9108498 15.4605 µM 0.175909402007094 0.430157957271016 no 1435 0.430182559401113 455 16459645
SGTC_2756 carbadox 75.1 µM 0.175268335296821 0.430415836400328 no 1436 0.430434395694878 456 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1070 indatraline 8.81 µM 0.17507352376511 0.43049420827663 no 1437 0.430510930960654 476 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_324 1315-0088 19.6 µM 0.173664325951149 0.431061204094527 no 1438 0.431064637603413 488 6787421
SGTC_154 3389-1638 511.116 µM 0.173608676878595 0.431083597623771 no 1439 0.431086506208732 487 5238686
SGTC_3250 9135583 49.47 µM 0.173159572222983 0.431264328203558 no 1440 0.431263000119856 429 7699353
SGTC_478 N-arachidonylglycine 10 µM 0.172213364125318 0.431645152296667 no 1441 0.431634895896129 470 5283389
SGTC_769 0302-0231 76 µM 0.171830850915522 0.431799121947098 no 1442 0.431785255358974 475 571869 YER009W NTF2
SGTC_3326 9140064 16.379 µM 0.171368792829767 0.431985123906177 no 1443 0.431966895742674 450 1868434
SGTC_1278 0874-0585 172 µM 0.171329489353728 0.432000946257408 no 1444 0.4319823470585 453 766306
SGTC_1436 4092-1007 8.32 µM 0.170830714931535 0.432201746719698 no 1445 0.432178438519838 452 2881121
SGTC_2338 7999974 200 µM 0.169784066683756 0.432623171340729 no 1446 0.43258997896861 482 315925
SGTC_1865 st057639 52.2 µM 0.169644499303116 0.432679372842978 no 1447 0.432644862179933 479 688818
SGTC_1943 st076331 65.2 µM 0.169540364642711 0.432721307055356 no 1448 0.432685812742293 489 24208415
SGTC_2045 5106652 78.05 µM 0.169314536147796 0.432812249024782 no 1449 0.432774621429434 487 673349
SGTC_371 0195-0006 7.36 µM 0.16815667561738 0.43327857953675 no 1450 0.433230011691891 457 3928593
SGTC_866 0495-0101 262 µM 0.167882190906379 0.433389142419741 no 1451 0.433337980434023 472 635694
SGTC_2816 7982706 58.44 µM 0.167488529909313 0.43354771880013 no 1452 0.433492835929662 456 2981853
SGTC_2223 6903751 107.57 µM 0.167435077975329 0.433569251385865 no 1453 0.433513863249957 480 5598863
SGTC_3057 9095946 49.47 µM 0.166047823550589 0.434128161963879 no 1454 0.434059657390083 478 24540043
SGTC_2561 acetosyringone 100 µM 0.16552402451843 0.434339229535322 no 1455 0.434265770903642 487 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_561 1550-0330 72.9 µM 0.165489027684787 0.434353332361041 no 1456 0.43427954270128 465 6812934
SGTC_593 1203-0218 61.7 µM 0.165381542429329 0.434396646682489 no 1457 0.434321840317452 476 3666956
SGTC_608 k048-0125 159 µM 0.164727968231447 0.434660040419876 no 1458 0.434579051116692 477 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_426 0988-0037 14.6 µM 0.164017414906754 0.434946429938958 no 1459 0.434858717177805 489 5383008
SGTC_2363 9053361 176 µM 0.163930174457417 0.434981594680707 no 1460 0.434893056319325 483 6469797 YMR079W SEC14
SGTC_2229 7354935 190 µM 0.163082457427338 0.435323317850887 no 1461 0.435226755913339 478 318112
SGTC_776 4476-4378 112 µM 0.162549205631624 0.435538301723024 no 1462 0.435436691485119 477 2892008
SGTC_528 3492-0019 172 µM 0.162352650088873 0.435617549156234 no 1463 0.435514077909137 455 2869262
SGTC_1531 st059297 52.4 µM 0.162282389145975 0.435645877651218 no 1464 0.435541741137763 466 7566702
SGTC_2526 patulin 37.61 µM 0.161774321776381 0.435850735047182 no 1465 0.435741787453502 443 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_797 k781-0471 270 µM 0.161541958179501 0.435944431907785 no 1466 0.435833283719279 465 23738129
SGTC_1332 1480-0653 17.5 µM 0.160624224767309 0.4363145281479 no 1467 0.436194687015645 488 5749438
SGTC_2176 5809774 33.9695 µM 0.159753812802782 0.436665592500585 no 1468 0.43653750436535 498 2870539
SGTC_743 1275-0778 158 µM 0.159404000990657 0.436806696608287 no 1469 0.436675293440961 477 2849257 YMR203W TOM40
SGTC_2961 9083290 32.55 µM 0.159061815833693 0.436944732120317 no 1470 0.436810085850478 489 17741490
SGTC_1450 4112-4260 37.6 µM 0.158215450399367 0.437286183981347 no 1471 0.437143514717911 481 1633175
SGTC_1330 1469-0054 61.8 µM 0.156733839224327 0.437884027343598 no 1472 0.437727308409233 490 7102664
SGTC_1403 3909-7815 62.9 µM 0.155673314390975 0.438312045765929 no 1473 0.438145266360641 485 6615483
SGTC_2361 9034121 116 µM 0.155570139210446 0.438353690214276 no 1474 0.43818593188763 462 6496917
SGTC_2950 9072895 21.46 µM 0.15551315486945 0.438376691013761 no 1475 0.438208392009501 440 17332245
SGTC_2357 9067248 200 µM 0.155465766185587 0.438395818841336 no 1476 0.438227070197832 476 9150235
SGTC_1597 7-benzyloxygramine 47.5 µM 0.154730696917195 0.43869253841844 no 1477 0.438516814394015 482 260807
SGTC_2318 6029776 164 µM 0.15341667240811 0.439223046017431 no 1478 0.439034848922605 479 818325
SGTC_350 k064-0020 19.8 µM 0.153326581420713 0.439259422220901 no 1479 0.439070369784015 461 2790705
SGTC_2662 daunorubicin 22.37 µM 0.153311919839761 0.439265342202912 no 1480 0.439076150563903 459 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1049 3226-0134 66 µM 0.152831185675705 0.439459458227869 no 1481 0.439265702006221 477 5702385
SGTC_1862 st057513 3.81 µM 0.15170847912416 0.439912853405999 no 1482 0.439708434606875 477 5393163
SGTC_1864 st057645 30.4 µM 0.150601253315677 0.440360074016596 no 1483 0.440145136333536 483 688666
SGTC_174 3553-0389 74.3 µM 0.148967319476952 0.441020176597838 no 1484 0.440789710232063 461 738071
SGTC_1666 st014829 29 µM 0.148726422745081 0.441117511798435 no 1485 0.44088475538874 462 3858230
SGTC_672 1441-0018 53.7 µM 0.148000230507518 0.441410953912293 no 1486 0.441171293163566 453 251141
SGTC_925 2064-1272 59.6 µM 0.147814397523337 0.441486051081986 no 1487 0.441244623289131 468 6815817
SGTC_2796 7949634 45.45 µM 0.147499985049827 0.441613113438259 no 1488 0.44136869576448 464 2971588
SGTC_415 dibenzyl ketone 100 µM 0.146882614582056 0.441862626565548 no 1489 0.441612337314918 495 7593
SGTC_755 1995-0008 37.3 µM 0.14663183491966 0.441963986919402 no 1490 0.441711312319301 492 689533
SGTC_2302 7771753 200 µM 0.146141299735786 0.442162262860137 no 1491 0.441904921956107 477 2203047
SGTC_2174 5790901 200 µM 0.145739035927208 0.44232487003569 no 1492 0.442063702069038 485 786020
SGTC_1072 oxiconazole 14.9 nM 0.145243526725661 0.442525183168946 no 1493 0.442259300458578 484 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1141 3253-0389 52.6 µM 0.143906527795202 0.443065747708085 no 1494 0.44278714045556 500 5402031
SGTC_2732 terfenadine 20 µM 0.143740859175192 0.443132736898399 no 1495 0.442852552628154 496 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_716 1683-5115 658 µM 0.143716826309036 0.443142454880103 no 1496 0.442862041832743 496 723597
SGTC_2983 9022671 12.99 µM 0.143594660280387 0.443191854728182 no 1497 0.442910278718354 484 6405161
SGTC_1240 0356-0016 42.1 µM 0.143002119212555 0.443431470993345 no 1498 0.44314425375335 498 4305613
SGTC_3177 9107506 49.47 µM 0.142459735134975 0.443650822529209 no 1499 0.443358440820064 490 8897194
SGTC_2113 5491891 107.031 µM 0.142369500145156 0.443687317135155 no 1500 0.443394076157509 475 789979
SGTC_2021 4019055 173 µM 0.14229715876221 0.443716575202283 no 1501 0.443422645334866 483 44827708 YER133W GLC7
SGTC_372 0155-0182 15.9 µM 0.141563001445108 0.444013518345625 no 1502 0.443712596555783 473 771486
SGTC_1364 1653-0028 37.6 µM 0.140109912782234 0.444601338733436 no 1503 0.444286574292296 503 5718652
SGTC_1180 1193-0155 285 µM 0.140032068960567 0.444632832475288 no 1504 0.444317326323836 470 2921347
SGTC_2366 9070441 60.58 µM 0.139571286655786 0.444819261087753 no 1505 0.444499364224559 456 6837235
SGTC_3158 9100007 49.47 µM 0.138901561428198 0.445090247987891 no 1506 0.444763968544477 474 19297233
SGTC_3077 9117319 49.47 µM 0.13788241700772 0.445502667474871 no 1507 0.445166673431667 499 17154678
SGTC_1163 k060-0048 49.9 µM 0.137845041728869 0.44551779333775 no 1508 0.445181442983535 455 6809982
SGTC_2036 5160441 105 µM 0.137652847420892 0.445595576076269 no 1509 0.445257393418834 466 134534 YIL048W NEO1
SGTC_2194 5927483 104.545 µM 0.136545740895579 0.446043672575553 no 1510 0.445694933565485 432 760979
SGTC_3040 9091894 49.47 µM 0.133819955582875 0.447147214767431 no 1511 0.446772473426605 482 25236966
SGTC_1711 st032263 62.8 µM 0.133743357126225 0.447178231830497 no 1512 0.446802759549857 480 3958979
SGTC_3032 9089427 49.47 µM 0.133560215621876 0.447252392748741 no 1513 0.446875172790702 493 17173707
SGTC_2801 7907800 81.82 µM 0.132871242423244 0.447531400540204 no 1514 0.447147605216181 502 6620925
SGTC_1395 3486-0190 4.35 µM 0.132001247925562 0.447883752110738 no 1515 0.447491652342608 489 6748079
SGTC_2661 dactinomycin 12.96 µM 0.130238582229557 0.448597765200441 no 1516 0.44818883515826 490 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2219 9098279 200 µM 0.129437189638977 0.448922445094339 no 1517 0.448505861052151 489 902349
SGTC_134 0269-0018 6.916 µM 0.128976192834195 0.449109230981042 no 1518 0.448688243416352 482 4378915
SGTC_2117 5521686 200 µM 0.128755210955172 0.449198772037639 no 1519 0.448775673460926 474 803312
SGTC_2899 9053889 58.44 µM 0.128478925456286 0.449310725559512 no 1520 0.448884987522259 500 6470052
SGTC_3204 9114183 49.47 µM 0.126876290968869 0.449960207670325 no 1521 0.449519156017493 459 17027248
SGTC_3218 9131285 49.47 µM 0.126849549714347 0.449971045947305 no 1522 0.44952973873083 496 17156417
SGTC_1518 st038567 90.8 µM 0.125924420502251 0.450346025347878 no 1523 0.449895875889333 501 77966
SGTC_2697 mebhydrolin 72.4 µM 0.124420919382051 0.450955528638337 no 1524 0.450491005385763 488 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1853 st056710 91.2 µM 0.123756577961844 0.451224882481853 no 1525 0.450754006598754 501 269167
SGTC_3304 9125678 46.087 µM 0.122990910838031 0.451535346167444 no 1526 0.451057147710798 508 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1378 2093-0007 380 nM 0.11982297657596 0.452820197194751 no 1527 0.452311690199066 509 3618014
SGTC_1109 tnp00067 928.257 nM 0.118906137958643 0.453192141467713 no 1528 0.452674859438675 489 676295
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.117923768745246 0.453590715844964 no 1529 0.453064029955944 499 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1485 3909-9022 254 µM 0.117870706807389 0.453612245876034 no 1530 0.453085051996915 504 714516
SGTC_1488 4013-0813 75.9 µM 0.117787237209763 0.45364611417678 no 1531 0.453118121189073 487 2910057
SGTC_3321 9137793 26.8275 µM 0.117765329362303 0.453655003476003 no 1532 0.453126800748278 480 4904192
SGTC_1060 3448-7350 82 µM 0.116756170631159 0.454064503485403 no 1533 0.453526638444966 468 570178
SGTC_1334 1486-0610 236 µM 0.1164670684234 0.45418182542289 no 1534 0.453641192019579 487 3742339
SGTC_1228 0124-0032 52.5 µM 0.115987259505869 0.454376547772869 no 1535 0.453831319541813 484 X1228
SGTC_696 1560-0013 611 µM 0.115658737530465 0.454509879198242 no 1536 0.453961504697383 474 1650269
SGTC_3096 9117468 49.47 µM 0.115343652987846 0.454637761825307 no 1537 0.454086369577271 519 41316311
SGTC_2919 7978188 46.38 µM 0.114823923564758 0.454848713459969 no 1538 0.454292343104609 492 2980291
SGTC_705 1124-0212 310 µM 0.111616034385739 0.456151034930184 no 1539 0.455563928933798 506 9554485
SGTC_2687 chenodiol 100 µM 0.111491263800707 0.456201698227144 no 1540 0.455613396443733 491 5702181 A cholesterol synthesis inhibitor.
SGTC_970 1315-0089 19.5 µM 0.110010425239001 0.456803049261921 no 1541 0.456200553477835 494 6811083 YLR033W RSC58
SGTC_1717 st033143 58.0435 µM 0.108262517274748 0.457512981231915 no 1542 0.456893727345583 501 674616
SGTC_990 3985-0011 41.3 µM 0.107950367623238 0.457639778567609 no 1543 0.457017531471432 503 5399565 YGL099W LSG1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.105846945576495 0.458494314852351 no 1544 0.45785189439401 477 4330530
SGTC_2407 paclitaxel 400 µM 0.104550580330408 0.459021072036641 no 1545 0.458366215438462 507 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3023 9089636 49.47 µM 0.104048995069999 0.459224902504156 no 1546 0.45856523355079 508 17249241
SGTC_1052 3253-3998 198 µM 0.100583350472403 0.460633535278608 no 1547 0.459940607033983 486 5450317
SGTC_1342 1486-1464 234 µM 0.1005632143988 0.460641721171793 no 1548 0.459948599640168 505 3253938
SGTC_50 0929-0078 56.389 µM 0.0996462827107414 0.461014497899377 no 1549 0.460312574182384 506 1377751
SGTC_1728 st035614 33.7865 µM 0.0983366502012946 0.461546985684956 no 1550 0.460832488274531 478 15945546
SGTC_489 paxilline 115 µM 0.0975072961378904 0.461884231192461 no 1551 0.461161770181164 489 105008 A toxic potassium channel blocker.
SGTC_3258 9138477 49.47 µM 0.0965626249280004 0.462268402217886 no 1552 0.461536869364199 492 4970355
SGTC_1221 2958-7315 257 µM 0.0959590355852675 0.462513883362459 no 1553 0.461776553618141 487 4562705
SGTC_3288 9119690 36.221 µM 0.0955072320314717 0.462697642233903 no 1554 0.461955973095249 501 17595618 YKL019W RAM2
SGTC_2832 7992762 51.95 µM 0.0952402165961772 0.4628062472831 no 1555 0.462062013463803 491 2985177
SGTC_2013 4024628 200 µM 0.0948542899135504 0.462963222830277 no 1556 0.462215282055028 490 5230760
SGTC_1782 st039423 80.636 µM 0.0946571715476775 0.463043402885505 no 1557 0.462293568661255 488 2068169
SGTC_1104 tacrolimus 29.8 µM 0.0945190965308222 0.463099567305941 no 1558 0.462348406757881 484 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3193 9111931 49.47 µM 0.0923929083131619 0.463964523632265 no 1559 0.463192936837796 490 17087244
SGTC_2304 7443016 91.4 µM 0.0884711007769301 0.465560401189598 no 1560 0.464751126245576 524 939854
SGTC_70 0141-0289 43.283 µM 0.0874895534941068 0.4659599040089 no 1561 0.46514119434765 492 352408
SGTC_2545 solidagenone 89.61 µM 0.0867658831966331 0.466254469452382 no 1562 0.465428803291595 495 6708572 An anti ulcer agent
SGTC_2725 haloperidol 53.21 µM 0.0867347354657611 0.466267148356472 no 1563 0.465441182769032 510 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_472 calcifediol 10 µM 0.0862138263855488 0.466479193144667 no 1564 0.465648219882915 496 5283731 A vitamin D metabolite.
SGTC_710 3448-4187 58 µM 0.0860856647378734 0.466531364956274 no 1565 0.465699159600039 487 3946412
SGTC_991 3996-0057 64.7 µM 0.0850175212936631 0.466966205141518 no 1566 0.466123730581473 484 715343
SGTC_2914 7968218 45.32 µM 0.0847833417005497 0.467061544720152 no 1567 0.466216818623689 515 2977111
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0830503206550914 0.467767153459971 no 1568 0.466905763841984 524 688669
SGTC_2390 9097792 176.6 µM 0.0829232557065952 0.467818892642191 no 1569 0.466956281170878 483 4497149
SGTC_1127 asiatic acid 681.4 nM 0.082221315959648 0.468104723083543 no 1570 0.467235361574406 477 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2974 9094440 9.66 µM 0.0815772911968256 0.468366984964042 no 1571 0.467491430046701 488 25236134
SGTC_2006 4011487 200 µM 0.0814311102860042 0.468426515150796 no 1572 0.467549554413403 501 45595294
SGTC_849 0386-0493 241 µM 0.0807264471890882 0.468713489488722 no 1573 0.467829751818773 504 726119
SGTC_606 k015-0008 38.6 µM 0.0804276956901173 0.468835161076109 no 1574 0.467948550137131 514 1970475
SGTC_853 0419-0306 21 µM 0.0801287313141178 0.468956922275109 no 1575 0.468067435963442 515 762713
SGTC_427 1354-0053 47.3 µM 0.0801119829158852 0.468963743592036 no 1576 0.468074096196361 493 6813657
SGTC_2910 7948405 25.97 µM 0.0796145377676585 0.469166348067131 no 1577 0.468271916227174 515 2971328
SGTC_416 estradiol valerate 100 µM 0.0791095993866471 0.469372012627263 no 1578 0.46847272411947 513 13791 A steroid.
SGTC_778 3456-2434 196 µM 0.0774832810941766 0.470034477511941 no 1579 0.46911954551989 506 5539063
SGTC_142 0335-0849 62.6745 µM 0.0774638187073371 0.470042405831203 no 1580 0.46912728662235 509 3889043 YPR107C YTH1
SGTC_2531 methyl deoxycholate 70.07 µM 0.0773429162455894 0.470091657677842 no 1581 0.469175375453273 514 16667744 Haematoxylin.
SGTC_1902 st060212 70.5 µM 0.0770906367788653 0.47019442984204 no 1582 0.469275720801315 499 688944
SGTC_3286 9117135 37.221 µM 0.0744114444654844 0.471285985015989 no 1583 0.470341501342077 522 3438150
SGTC_455 paf C-16 10 µM 0.0738840081548313 0.471500898525674 no 1584 0.470551340355205 503 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1261 0712-0010 12.7 µM 0.0738280383927851 0.471523704910497 no 1585 0.470573608244348 508 2840123
SGTC_1281 0884-0031 11.8 µM 0.0708752367416638 0.472727033950087 no 1586 0.471748526008956 510 1548255
SGTC_57 miconazole 162.5 nM 0.0701291952460781 0.473031101444984 no 1587 0.472045414728006 510 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2792 7535235 81.82 µM 0.0686330076290611 0.47364095656034 no 1588 0.472640872258265 506 1281891
SGTC_1245 0418-0076 17.2 µM 0.0683904051688534 0.473739848648073 no 1589 0.472737429757207 513 6790114
SGTC_343 4130-2827 29.8 µM 0.0680955611593349 0.473860038146626 no 1590 0.472854781919249 486 1118244
SGTC_3019 9081971 49.47 µM 0.0680698447722246 0.473870521225412 no 1591 0.47286501752354 509 16451803
SGTC_2103 5378138 10 µM 0.0680093385239388 0.473895186183211 no 1592 0.472889100215602 519 244142
SGTC_641 4092-0595 30 µM 0.0672799356922723 0.474192530100054 no 1593 0.473179424844476 510 786260
SGTC_2849 9019321 12.99 µM 0.0669495578854716 0.47432721464579 no 1594 0.473310930010518 520 16489627
SGTC_2994 9053520 71.4286 µM 0.0643905594609903 0.475370535297268 no 1595 0.474329623443696 504 4647384
SGTC_1687 st020778 55.3625 µM 0.0639509701258714 0.475549775986384 no 1596 0.474504633507035 522 4259299
SGTC_668 1682-0499 62.6 µM 0.0638082609459033 0.475607966115616 no 1597 0.474561450191107 524 682214
SGTC_361 000s-0510 1.45 µM 0.0635922873574048 0.475696031033188 no 1598 0.474647436555244 508 660
SGTC_879 0831-1030 162 µM 0.0632322753685287 0.475842831370421 no 1599 0.474790772083889 525 1549252
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0604524515826048 0.476976455502996 no 1600 0.475897642343011 531 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_334 1502-1024 68.5 µM 0.0590693117026199 0.477540575911984 no 1601 0.476448450829808 516 3296216
SGTC_2089 5281248 129.67 µM 0.0568227130132948 0.478456957667721 no 1602 0.477343210399376 504 2737878
SGTC_365 0121-0052 13.6 µM 0.0560656890719438 0.478765771660463 no 1603 0.477644738540428 522 3101739
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.055076111273534 0.479169470917197 no 1604 0.478038913846479 509 688788
SGTC_1757 st041620 31.8375 µM 0.0550275779077045 0.47918927070565 no 1605 0.478058246540058 507 5289815
SGTC_652 0437-0092 114 µM 0.0545407783466699 0.479387869456066 no 1606 0.478252160249465 515 3091274
SGTC_780 0109-0199 192 µM 0.0544946739333488 0.479406678857552 no 1607 0.478270525935874 527 610414
SGTC_3154 9100113 49.47 µM 0.0534193184251182 0.479845408856443 no 1608 0.478698906655173 515 25237525
SGTC_39 0986-0283 58.349 µM 0.053241559998024 0.479917934173167 no 1609 0.478769721232573 518 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0518480346083317 0.480486514424916 no 1610 0.479324890456411 535 5282309
SGTC_1819 st053448 58.6 µM 0.050906417905824 0.480870731380927 no 1611 0.479700045696727 523 2857616
SGTC_1343 1487-0095 224 µM 0.0506050582778748 0.480993701831054 no 1612 0.479820116034522 529 4560101 YGL055W OLE1
SGTC_114 0364-0001 490.298 µM 0.0500957381738031 0.481201535109957 no 1613 0.480023047960289 500 4003655
SGTC_2556 citropten 84.59 µM 0.0484915700223035 0.481856165461584 no 1614 0.480662241343805 521 2775 A potential DNA crosslinker.
SGTC_1175 0741-0056 27.6 µM 0.0484513280159924 0.481872588091377 no 1615 0.480678276733076 513 765927
SGTC_1925 st057770 10.1 µM 0.0483465716336345 0.481915338969035 no 1616 0.480720019564058 475 5989122
SGTC_656 4090-1979 187 µM 0.0480960486755358 0.48201757774762 no 1617 0.480819847631656 523 22330961
SGTC_2700 st077718 96.8 µM 0.0476838535262776 0.482185797749908 no 1618 0.480984101241765 519 904970
SGTC_2312 7706453 155.7 µM 0.0474710878180095 0.482272630310526 no 1619 0.481068886463548 517 976098
SGTC_1787 fluconazole 80 µM 0.0472981479672193 0.482343210020295 no 1620 0.481137802070288 525 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_163 TUB2.036 7.546 µM 0.047222751320988 0.482373980853987 no 1621 0.481167847407637 532 15992207 YJR013W GPI14
SGTC_3150 9097574 49.47 µM 0.0464425489053414 0.482692402723696 no 1622 0.481478761979588 521 17217476
SGTC_1349 flufenamic acid 69 µM 0.0433216658680277 0.483966228527887 no 1623 0.48272256028413 518 3371 A non-steroidal anti-inflammatory.
SGTC_2783 7738165 71.43 µM 0.0428541226852318 0.484157076292966 no 1624 0.482908909960355 532 17201110
SGTC_904 1141-0088 396 µM 0.04023360430089 0.485226818994273 no 1625 0.483953443476463 522 1378119
SGTC_1145 3546-0597 10.2 µM 0.0392075307806733 0.48564571003895 no 1626 0.48436246477999 525 875334
SGTC_389 tpck 16.7 µM 0.038640073100607 0.485877379549775 no 1627 0.48458867621074 507 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1044 1222-0021 1.78 µM 0.0385539583098881 0.485912537077143 no 1628 0.484623005461538 513 4306703
SGTC_1430 4049-0248 69.1 µM 0.0379773129482141 0.486147963149069 no 1629 0.484852885310496 526 22774488
SGTC_2747 doxorubicin 7.63 µM 0.0375888346236187 0.486306569295071 no 1630 0.485007755155713 532 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1074 carmofur 3.8 µM 0.0370003085077883 0.486546854152681 no 1631 0.485242379878293 527 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1033 k072-0102 21.3 µM 0.0367036377900021 0.486667981443712 no 1632 0.485360654031101 535 5965931
SGTC_2931 9014674 55.67 µM 0.0349473851294875 0.487385064313445 no 1633 0.486060847900352 531 2996810
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0348872912908986 0.487409601530569 no 1634 0.486084807263028 535 5393153
SGTC_1982 st072467 71.9 µM 0.0348541455497857 0.487423135455034 no 1635 0.486098022463505 507 3163533
SGTC_149 3970-0822 46.1 µM 0.0347916660590365 0.487448646847599 no 1636 0.486122933065708 514 3114250 YBL034C STU1
SGTC_1296 1068-0102 11.9 µM 0.0346292454264052 0.487514966074399 no 1637 0.486187690501062 530 767053
SGTC_933 2914-0560 114 µM 0.0338540840000556 0.4878314829657 no 1638 0.486496753920184 501 463887
SGTC_560 2332-1943 155 µM 0.0333036900039686 0.488056226621316 no 1639 0.486716205597998 535 21177716
SGTC_2808 7946468 45.46 µM 0.0329732354157499 0.488191163735721 no 1640 0.48684796553793 528 2970879
SGTC_3104 9120930 49.47 µM 0.0324826414315314 0.488391494314513 no 1641 0.487043579427951 531 17014836
SGTC_1374 2889-5571 141 µM 0.032002010419069 0.488587759424953 no 1642 0.48723522381871 528 2853281
SGTC_1830 st055982 50.3 µM 0.0317182894389144 0.488703617854819 no 1643 0.487348354680754 528 455313 An antimicrobial agent.
SGTC_483 fpl-64176 144 µM 0.0292671703022659 0.489704579368776 no 1644 0.488325754991843 539 3423
SGTC_1873 rapamycin 2 nM 0.0283945241692962 0.490060957134512 no 1645 0.488673745760965 534 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2198 6589944 200 µM 0.0278157083192474 0.490297342682494 no 1646 0.488904568691656 533 5290268
SGTC_2420 aureobasidin a 50 nM 0.0275745021239313 0.49039585111776 no 1647 0.489000759144009 508 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1877 wortmannin 25 µM 0.0252115705905573 0.491360900690033 no 1648 0.489943103946948 540 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2522 biochanin a 4.94 µM 0.0247829736641033 0.491535950397567 no 1649 0.490114035967909 533 5280373 A possible chelator.
SGTC_2050 5263056 171 µM 0.0224943128259814 0.492470723509983 no 1650 0.49102682428053 531 763468 YGL055W OLE1
SGTC_938 3126-1755 342 µM 0.0209663412479727 0.493094826535269 no 1651 0.491636252781755 538 1777771
SGTC_1260 0700-1617 7.75 µM 0.0209540295351867 0.493099855349503 no 1652 0.491641163365729 535 2853078
SGTC_1901 st060216 58.6 µM 0.0206573108289259 0.493221052728003 no 1653 0.491759511384833 532 688792
SGTC_66 0109-0187 42.4 µM 0.0206534736575512 0.493222620058693 no 1654 0.49176104186821 519 759417
SGTC_2759 disulfiram 3.38 µM 0.0201528582923043 0.493427102256126 no 1655 0.49196071693593 536 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2948 9070189 9.45 µM 0.017040247791367 0.49469852105437 no 1656 0.493202253666083 540 6473636 YDL196W YDL196W
SGTC_1804 st050076 49.1 µM 0.0165182140844701 0.494911763596176 no 1657 0.493410485666043 539 3895976
SGTC_3340 9146634 11.102 µM 0.0162311203196504 0.495029037497954 no 1658 0.493525004152942 543 4907387
SGTC_3018 9082602 49.47 µM 0.0161423378941863 0.495065303999784 no 1659 0.49356041857643 531 17332089
SGTC_3280 9140961 49.47 µM 0.0154541228112301 0.495346432547782 no 1660 0.493834942405088 541 4901226
SGTC_2066 5222451 176 µM 0.0152842006544542 0.495415844304276 no 1661 0.49390272353192 542 2281147
SGTC_1258 0671-0043 57.1 µM 0.0149151076180445 0.495566616147208 no 1662 0.494049953563562 537 4298767
SGTC_368 fentichlor 4.58 µM 0.0140642315724661 0.495914195251078 no 1663 0.49438936835126 537 7329 A pesticide.
SGTC_2157 5649910 96.377 µM 0.0138871393580336 0.495986537036663 no 1664 0.494460011023742 534 2858091
SGTC_2966 9084041 48.03 µM 0.0129576791091816 0.496366221641744 no 1665 0.494830778601171 529 17741380
SGTC_964 1287-0107 19.4 µM 0.0127312372283282 0.496458723684622 no 1666 0.494921108389688 543 51516812 YPR165W RHO1
SGTC_401 neomycin 50 µM 0.0126895878454288 0.496475737576734 no 1667 0.49493772274736 531 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_278 4092-0821 23.9 µM 0.0112564404842278 0.49706118607069 no 1668 0.495509424795777 544 877900
SGTC_764 1951-2361 146 µM 0.0105818078619515 0.497336779435108 no 1669 0.495778548223533 537 5438930
SGTC_1824 st053723 68.6 µM 0.0100301653980409 0.497562131187734 no 1670 0.495998610036199 538 675225
SGTC_2258 7960471 200 µM 0.00817883524653266 0.498318424313438 no 1671 0.496737153192885 540 2974708
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.00604571119156121 0.499189841339583 no 1672 0.497588124883189 544 5106787 A p450 inhibitor.
SGTC_493 zm226600 134 µM 0.00583909688676441 0.499274247027322 no 1673 0.497670550609633 544 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3272 9137413 49.47 µM 0.00567272073459135 0.499342214724316 no 1674 0.497736923991609 537 17614870
SGTC_318 1488-0629 67.2 µM 0.00521938904435179 0.499527409090933 no 1675 0.497917774486354 545 3662576
SGTC_540 1187-0821 17.3 µM 0.00423132221767 0.499931052933635 no 1676 0.498311951702532 547 847520
SGTC_1975 st070967 30.8 µM 0.0042223193290366 0.49993473078356 no 1677 0.498315543303369 547 261391
SGTC_3184 9108758 49.47 µM 0.0041387642969852 0.499968864591369 no 1678 0.498348876647102 546 902885
SGTC_3273 9137859 49.47 µM 0.00398633360050333 0.499968864591369 no 1679 0.498409687194881 547 2377234
SGTC_605 1315-0399 119 µM 0.00381665093892937 0.499899546021625 no 1680 0.498477380267551 544 24020461
SGTC_744 1594-0068 283 µM 0.00276671336071774 0.499470626852937 no 1681 0.498896242470814 547 668392
SGTC_806 3966-4455 5.86 µM 0.00222794817805844 0.49925053138971 no 1682 0.499111178008545 540 714982
SGTC_212 3807-4682 38.772 µM 0.00137403884219398 0.498901694251187 no 1683 0.499451837983422 546 3125501 YBL034C STU1
SGTC_648 0375-0473 33.3 µM 0.00051041152022096 0.498548887997809 no 1684 0.499796375273021 548 1713139
SGTC_962 1254-0300 21.5 µM 0.000448724656111749 0.498523687918824 no 1685 0.499820984768426 548 7340576
SGTC_16 erodoxin 22.806 µM 0.000197165640752615 0.498420922065517 no 1686 0.499921342290171 547 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1376 2910-0861 41.3 µM -0.00027179023537675 0.498229346426634 no 1687 0.499891571385043 548 1112859
SGTC_430 0958-0115 16.4 µM -0.000301693786853058 0.498217130382448 no 1688 0.499879641594516 549 6833180
SGTC_1012 4112-3522 18 µM -0.000341732542154263 0.498200773959836 no 1689 0.499863668442999 549 3112398
SGTC_2274 7947094 46.08 µM -0.000467134293170644 0.498149545513001 no 1690 0.499813640386607 549 2971028
SGTC_1917 st066507 28.5 µM -0.000472779461597465 0.49814723937996 no 1691 0.49981138829049 542 3156428
SGTC_2743 auranofin 4.32 µM -0.000937117041978926 0.497957550974176 no 1692 0.499626144444989 549 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1916 st067606 49.2 µM -0.00205606808541864 0.497500445779154 no 1693 0.499179748087267 550 19590279
SGTC_3278 9139605 49.47 µM -0.0036180905780698 0.496862346095219 no 1694 0.498556593843257 554 7958859
SGTC_1323 1348-1351 11.2 µM -0.00373842153945976 0.496813190170027 no 1695 0.498508589059889 549 6989654
SGTC_1370 2001-0092 44.6 µM -0.00396305531336885 0.496721426045402 no 1696 0.498418973814477 545 790957
SGTC_1683 st010134 710 nM -0.00433160677363928 0.496570871137188 no 1697 0.498271944319789 553 3818134
SGTC_1952 st077036 64.1 µM -0.0044934850742876 0.496504743285595 no 1698 0.498207364850154 550 2937007
SGTC_2057 5236571 38.335 µM -0.00500182522603707 0.496297085189666 no 1699 0.498004568758527 553 54684039 YBR257W POP4
SGTC_2263 7948595 193.29 µM -0.00534250538787844 0.496157917134972 no 1700 0.497868658856427 557 2971371
SGTC_252 miconazole 1.30953 nM -0.00595640986008607 0.495907137974078 no 1701 0.497623750318508 555 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2242 6630449 61.2675 µM -0.00677119766824404 0.495574300752021 no 1702 0.497298703603207 560 691249 YDR170C SEC7
SGTC_524 r073-0010 27.8 µM -0.00678936668977896 0.495566878821201 no 1703 0.497291455378934 560 2772106
SGTC_2485 5633444 17.78 µM -0.00709294592328331 0.495442868846072 no 1704 0.4971703477052 552 5724239
SGTC_1155 4088-0394 48.2 µM -0.00754606641313849 0.495257773145589 no 1705 0.496989583627525 552 2326248
SGTC_1524 corynanthine 62.1 µM -0.00841219555358854 0.494903969949647 no 1706 0.496644059103261 561 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_840 0245-0196 390 µM -0.00869095352041697 0.494790101557471 no 1707 0.496532854830881 552 3827528
SGTC_1443 4112-3303 14 µM -0.00993434364483134 0.494282200891602 no 1708 0.49603683548038 548 704433
SGTC_906 1165-0455 526 µM -0.0115638685145121 0.493616585859809 no 1709 0.495386786740282 565 3252859
SGTC_2977 9011197 71.43 µM -0.0135321864100572 0.492812607285362 no 1710 0.494601603454382 555 2704722
SGTC_2772 vinpocetine 57.06 µM -0.0153684703246052 0.492062585531575 no 1711 0.493869108745782 553 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1132 3456-3614 2.5 µM -0.0173864375880882 0.491238388510005 no 1712 0.493064164379203 568 3125502
SGTC_2904 7225135 42.03 µM -0.018365703815969 0.49083844072173 no 1713 0.492673556107922 558 4446116
SGTC_3072 9116419 49.47 µM -0.0188110844438451 0.490656543264634 no 1714 0.49249590564035 554 17170162
SGTC_1839 st053978 48 µM -0.019313734905877 0.490451258627701 no 1715 0.492295413551155 559 3788398
SGTC_2607 solasodine 47.35 µM -0.0197458971069654 0.490274763723498 no 1716 0.4921230386547 562 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0206917177913136 0.489888497551537 no 1717 0.491745787926057 558 688662
SGTC_2896 9052656 71.43 µM -0.0211619505977742 0.489696461458057 no 1718 0.491558233252286 560 6469436
SGTC_3071 9117417 49.47 µM -0.0224319207152798 0.489177836587786 no 1719 0.491051708852383 561 45595590 YGL055W OLE1
SGTC_3128 9127691 49.47 µM -0.0225199568072721 0.489141885459731 no 1720 0.491016596403058 560 41316314
SGTC_2297 7971671 152.32 µM -0.0227628964259423 0.489042677137594 no 1721 0.490919702356608 561 909016
SGTC_2116 5511452 16.8835 µM -0.0229806162603772 0.48895376829806 no 1722 0.490832867424937 566 870744
SGTC_2443 5493264 126.67 µM -0.0231666572220142 0.48887779638951 no 1723 0.490758667573919 576 5340055
SGTC_383 2324-0395 7.37 µM -0.0252542010144793 0.488025352834406 no 1724 0.489926102281745 563 3146421
SGTC_2735 sertaconazole 140 nM -0.0254741840759775 0.487935526391519 no 1725 0.489838369963211 560 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_169 k015-0017 16.025 µM -0.0261842984385144 0.48764556714206 no 1726 0.489555169810231 567 1840002
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0269256726527083 0.487342850604745 no 1727 0.489259508561054 558 4000243
SGTC_2982 9019404 25.97 µM -0.0282570530600644 0.486799242261275 no 1728 0.488728566801477 565 22333232
SGTC_1018 4259-0013 28.1 µM -0.0284381003731175 0.486725321737084 no 1729 0.488656368388259 572 6801262
SGTC_3263 9137018 49.47 µM -0.0293417997734708 0.48635635360186 no 1730 0.488295994921438 557 43844957
SGTC_1136 pergolide 1.05886 µM -0.0294302490954534 0.486320241572874 no 1731 0.488260723979433 556 47811 A dopamine receptor agonist.
SGTC_566 0958-0068 16.5 µM -0.0302712773621004 0.485976872770885 no 1732 0.487925351707786 568 6815365
SGTC_3301 9125354 19.7965 µM -0.03102718004532 0.485668267276737 no 1733 0.487623931781212 566 41905162
SGTC_3210 9128157 49.47 µM -0.0312850505364291 0.485562990797492 no 1734 0.487521106258387 590 17590849
SGTC_2837 9008476 45.46 µM -0.0314335039906019 0.485502384640677 no 1735 0.487461911012486 565 2992805
SGTC_200 k038-0079 37.545 µM -0.0318167854190494 0.48534591146119 no 1736 0.487309080292238 556 3436683
SGTC_1838 st055369 84.5 µM -0.0319454588774745 0.485293381517864 no 1737 0.487257773090442 558 676036
SGTC_2131 toluylene red 5.2905 µM -0.0320995267833937 0.48523048482374 no 1738 0.487196340394628 562 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2860 9025725 38.96 µM -0.0321314830372373 0.485217439046098 no 1739 0.487183598266693 589 40546248
SGTC_2797 7859098 81.82 µM -0.0321807145285164 0.48519734087997 no 1740 0.487163967894967 559 972681
SGTC_23 0213-0011 39.996 µM -0.0342066200821483 0.484370322428509 no 1741 0.486356193784842 570 627608
SGTC_2360 9040895 200 µM -0.0342921030149936 0.484335427900303 no 1742 0.48632211102441 571 4914414
SGTC_2600 tangeritin 87.95 µM -0.0343699695359709 0.484303642531019 no 1743 0.486291065078051 572 68077 A bioactive flavone.
SGTC_2163 5671233 125 µM -0.0347138602772044 0.484163266398126 no 1744 0.486153954343031 559 701023
SGTC_43 0570-0105 72.5 µM -0.0348768347332598 0.484096740941698 no 1745 0.486088976288857 563 1114046 YDL195W SEC31
SGTC_2967 9089538 49.85 µM -0.034938647497326 0.484071509358865 no 1746 0.486064331583789 566 728216
SGTC_860 0443-0016 25.1 µM -0.0363376549186807 0.483500460551704 no 1747 0.485506562735685 564 5337942
SGTC_2475 5812728 15.03 µM -0.0380053820388072 0.482819769677694 no 1748 0.484841695441808 570 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2337 9009472 200 µM -0.0409233102204724 0.481628924847648 no 1749 0.483678517071194 565 5742383
SGTC_338 4055-0136 114 µM -0.0413483677625584 0.481455466704481 no 1750 0.483509087059099 571 2900563
SGTC_2320 7373003 200 µM -0.0417047010644101 0.481310056360057 no 1751 0.483367053158035 578 5415828
SGTC_73 0327-0325 16.231 µM -0.0422982376841464 0.481067855046459 no 1752 0.483130475077452 575 53298
SGTC_834 0312-0008 75.7 µM -0.0426817806126677 0.480911348446575 no 1753 0.482977601649068 565 6385573 YIL048W NEO1
SGTC_1940 st075990 51.1 µM -0.0431502407521099 0.480720194950228 no 1754 0.482790885119419 580 1084979
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0438704351594017 0.480426330841722 no 1755 0.482503840963828 563 368090
SGTC_35 0133-0054 64.071 µM -0.0443280396255447 0.480239617984545 no 1756 0.482321460623842 580 99677
SGTC_2935 9038016 29.96 µM -0.044539693267645 0.480153260028484 no 1757 0.48223710635169 566 6463195
SGTC_2388 9080168 200 µM -0.0447128000358702 0.480082630484819 no 1758 0.482168115474852 570 15943073
SGTC_131 0141-0277 33.849 µM -0.0450339992594469 0.479951579181843 no 1759 0.482040104472472 581 1547771
SGTC_2887 9044784 58.44 µM -0.0450356049402136 0.479950924059425 no 1760 0.482039464547781 572 6465546
SGTC_2805 7950783 58.44 µM -0.045329233182668 0.479831123795702 no 1761 0.481922443335083 574 1178958 YDL195W SEC31
SGTC_2843 9000894 45.46 µM -0.0463353925140858 0.47942062487495 no 1762 0.481521465222591 560 2242070
SGTC_1299 1079-1439 3.74 µM -0.0464777118374415 0.479362562335491 no 1763 0.481464749131109 580 323161
SGTC_2745 rifampicin 24.3 µM -0.0473986612358437 0.478986849851381 no 1764 0.481097748000919 564 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1416 3966-0321 25.3 µM -0.0477233149413395 0.478854407866003 no 1765 0.480968376317107 574 582530 YLR208W SEC13
SGTC_1768 st044301 37.178 µM -0.0497745007997191 0.478017684289962 no 1766 0.480151043451374 570 3931349
SGTC_2077 5212015 200 µM -0.0506186270709322 0.477673374650273 no 1767 0.479814709797909 568 780900
SGTC_281 1672-3440 14.9 µM -0.0509923367453604 0.477520947971673 no 1768 0.479665813498448 567 6833000
SGTC_2368 9071271 200 µM -0.0510006740086782 0.477517547451269 no 1769 0.47966249173378 584 27209959
SGTC_1685 st024049 53.0905 µM -0.0510353880060228 0.477503388667383 no 1770 0.479648660864003 571 1941139
SGTC_307 1501-1223 22.3 µM -0.0515392184578166 0.477297894753251 no 1771 0.479447925775965 576 2830329
SGTC_1622 st003707 19.4 µM -0.051604452973266 0.477271288433463 no 1772 0.479421935555107 568 10140899
SGTC_2158 5657123 3.6195 µM -0.0525181544394011 0.476898640071676 no 1773 0.479057915072464 608 2858827
SGTC_2693 st077581 40.7 µM -0.0525681155025759 0.476878264293021 no 1774 0.479038010986376 584 25238761
SGTC_2446 5162541 200 µM -0.0526861477494699 0.476830127068085 no 1775 0.478990988095427 568 1549321
SGTC_1927 st060202 13.8 µM -0.0529252814532597 0.476732601935937 no 1776 0.478895720467378 576 688887
SGTC_502 l-744,832 89.3 µM -0.0532577424096506 0.476597017766243 no 1777 0.478763274530752 586 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1470 k295-0292 231 µM -0.0536965142940666 0.476418082042188 no 1778 0.478588479993779 567 5045612
SGTC_670 4204-0025 119 µM -0.0537147548607338 0.476410643452664 no 1779 0.478581213547366 568 719039
SGTC_392 N-ethylmaleimide 8.33 µM -0.0543237703540513 0.476162288783631 no 1780 0.478338605754326 570 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2253 7938677 135.83 µM -0.0548267324595676 0.475957189341483 no 1781 0.478138251502756 586 2301972
SGTC_1847 st056231 15 µM -0.0561596935868019 0.475413661287709 no 1782 0.477607295159096 580 5393180
SGTC_3142 9086498 49.47 µM -0.0567544840063995 0.475171144325987 no 1783 0.477370385979748 583 25236367
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0584449312793645 0.474481940074754 no 1784 0.476697112964484 576 6708760
SGTC_1288 0973-0013 65.5 µM -0.0589922957272434 0.474258792974299 no 1785 0.47647912227266 577 4315430
SGTC_2125 5246583 200 µM -0.0591625886385575 0.474189370362409 no 1786 0.476411303682019 580 835267
SGTC_1565 sinapyl alcohol 95.1 µM -0.0619081027181 0.473070227554098 no 1787 0.475318007420746 572 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1444 4112-3581 28 µM -0.0619201745803416 0.473065307212527 no 1788 0.475313200666341 564 2877249
SGTC_1032 k061-1018 98.7 µM -0.0631158001825819 0.472578005502917 no 1789 0.474837146328907 607 4005393
SGTC_794 k038-0031 316 µM -0.0635792736126362 0.472389118409026 no 1790 0.474652617803378 573 6624242
SGTC_693 4161-2696 114 µM -0.0638453914380765 0.472280665755442 no 1791 0.474546667410094 574 805759
SGTC_1426 4048-4480 71.7 µM -0.0644968936240873 0.472015163705607 no 1792 0.474287290246291 599 14224343
SGTC_1195 1502-0147 41.1 µM -0.0646627939477863 0.471947557508954 no 1793 0.474221243462521 576 817940
SGTC_3190 9110366 49.47 µM -0.0656235594749485 0.471556051002268 no 1794 0.473838765895752 587 17123768
SGTC_126 0417-1624 672.48 µM -0.0656415351023915 0.471548726296722 no 1795 0.473831610086851 582 41912 YDL195W SEC31
SGTC_2270 7924575 90.91 µM -0.0666488602451644 0.471138277075119 no 1796 0.473430623669692 606 1262135
SGTC_647 0140-0236 81 µM -0.0680226783013193 0.470578544506044 no 1797 0.472883790709967 589 990837
SGTC_1857 st056007 79.3 µM -0.0684419561591232 0.470407730300997 no 1798 0.472716911963406 576 619834
SGTC_37 0566-0070 1.56 µM -0.0687007040909961 0.470302318858064 no 1799 0.472613928873184 590 1626686
SGTC_2512 diallyl trisulfide 49.23 µM -0.0689729819381094 0.470191397703761 no 1800 0.472505562779639 575 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2710 st078562 53.7235 µM -0.0690804776863025 0.47014760648338 no 1801 0.472462780225038 592 17250908
SGTC_781 4335-2806 94.4 µM -0.0727050479793289 0.468671257131511 no 1802 0.471020415738281 623 845254
SGTC_1361 1608-0041 5.61 µM -0.0732628600779813 0.468444088477083 no 1803 0.470798472805334 576 X1361
SGTC_2979 9012552 45.46 µM -0.0738101076298967 0.468221232212025 no 1804 0.470580742120124 579 17100905
SGTC_1379 2144-0755 36.5 µM -0.0742328221023914 0.468049096512936 no 1805 0.470412564814084 582 5392327
SGTC_119 0121-0043 24.815 µM -0.0747128434376907 0.46785363184154 no 1806 0.470221594325268 583 1092378
SGTC_325 2810-4341 181 µM -0.0747689050617672 0.467830804054654 no 1807 0.470199291354605 578 774970
SGTC_187 1488-2104 32.728 µM -0.0752106946185933 0.467650915045627 no 1808 0.470023537690901 577 2852859
SGTC_1313 1220-0047 237 µM -0.0755696243287138 0.467504769984355 no 1809 0.469880751806088 578 3528706
SGTC_3318 9139014 38.6185 µM -0.076216329353559 0.467241462796543 no 1810 0.469623495765481 580 16643984
SGTC_266 formosanin C 406 nM -0.0762174036998101 0.467241025386307 no 1811 0.469623068406409 586 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1719 st032227 49.2 µM -0.076531299634117 0.467113227227879 no 1812 0.469498206740284 584 3125804
SGTC_635 k038-0028 24.7 µM -0.0772092337238001 0.466837227820578 no 1813 0.469228548063513 585 4035102
SGTC_650 1328-0195 38 µM -0.0783709759541426 0.46636429838921 no 1814 0.468766480167779 581 2780821
SGTC_689 0833-0039 98 µM -0.0793086691765873 0.465982610859046 no 1815 0.468393555508974 604 5374726
SGTC_787 4152-0075 138 µM -0.0796670390201418 0.465836744848552 no 1816 0.468251037575932 575 9566539
SGTC_3223 9129970 49.47 µM -0.0797729929587338 0.465793619669661 no 1817 0.468208902174185 579 17248386
SGTC_1987 st072290 61.9 µM -0.0813884357805845 0.465136155123494 no 1818 0.467566522755363 598 54697379
SGTC_441 propafenone 146 µM -0.0815691673251403 0.465062605584528 no 1819 0.467494660237544 582 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3188 9110789 49.47 µM -0.0817954517561873 0.4649705197705 no 1820 0.467404686464499 599 849217
SGTC_945 3381-0768 11.3 µM -0.0826509692539172 0.464622386321083 no 1821 0.467064536138674 588 1126236 YIL048W NEO1
SGTC_1654 st012436 41.8 µM -0.0830816887409609 0.464447125023374 no 1822 0.466893292885137 593 4323132
SGTC_2643 anethole 100 µM -0.0838824785599964 0.464121299145296 no 1823 0.466574935270406 593 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1590 st077108 57.8 µM -0.084636087326187 0.463814692296336 no 1824 0.466275354224333 580 5489485
SGTC_1285 0929-0069 65.5 µM -0.0848807184343022 0.463715168377052 no 1825 0.466178110459502 584 1206237
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0850877970991374 0.463630923791688 no 1826 0.466095795813759 595 7104
SGTC_3191 9110352 49.47 µM -0.0853474947192399 0.46352527485423 no 1827 0.465992566960995 584 17122424
SGTC_1422 4031-0024 15.5 µM -0.0860737483037353 0.463229837540732 no 1828 0.465703895989254 595 782427
SGTC_522 1273-0010 11.6 µM -0.0865962545406017 0.463017296440071 no 1829 0.465496221580732 574 5705015
SGTC_2370 9071495 200 µM -0.0875299865776183 0.462637506374532 no 1830 0.465125125526249 623 21791103
SGTC_958 1222-0007 33 µM -0.0878022700123841 0.462526763072357 no 1831 0.46501691676325 603 7312461
SGTC_54 0159-0055 9 µM -0.0894521044379848 0.461855803730505 no 1832 0.464361308022744 602 3319099
SGTC_59 0330-0160 1.33 µM -0.0907461044500298 0.461329631990391 no 1833 0.463847167839842 584 4293482
SGTC_3347 9188721 44.724 µM -0.0918025331464223 0.460900112643757 no 1834 0.46342746570185 589 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2141 5621638 7.665 µM -0.0925624535158176 0.460591174865143 no 1835 0.463125586698003 603 2856238
SGTC_2853 9015042 58.44 µM -0.0926548348255176 0.460553619815531 no 1836 0.463088889589368 571 6457456
SGTC_1151 3909-8316 15.3 µM -0.0926681500001265 0.460548206930984 no 1837 0.463083600359125 605 800431
SGTC_1152 3909-8331 15.9 µM -0.0937990714920115 0.46008849152678 no 1838 0.462634384638222 594 16001939
SGTC_2933 9026794 32.47 µM -0.0939450840338076 0.460029141844043 no 1839 0.462576390148389 595 17586027
SGTC_1797 st048695 56.8 µM -0.0943700577334525 0.459856407959465 no 1840 0.462407600050427 583 592262 YIL048W NEO1
SGTC_2175 5807670 165.306 µM -0.0958202806828281 0.459267010736112 no 1841 0.46183165490868 591 241186
SGTC_2508 celastrol 40.54 µM -0.0971009614642264 0.458746592950625 no 1842 0.461323108666695 589 122724 Celastrol is a natural product and antioxidant.
SGTC_1642 st009582 77.7 µM -0.0985421624780966 0.458161030706886 no 1843 0.460750897020113 610 6739311
SGTC_846 0335-0850 148 µM -0.100139175709578 0.457512267809868 no 1844 0.46011691695513 599 6819598
SGTC_288 1315-0019 35.1 µM -0.100377355142943 0.457415520612288 no 1845 0.460022373467436 595 6811474
SGTC_1912 st060209 90.8 µM -0.100502173827257 0.457364820945223 no 1846 0.459972828556405 596 688787
SGTC_2585 alliin 100 µM -0.100502527051956 0.457364677471096 no 1847 0.459972688350022 598 87310 A garlic compound which reacts with lipids.
SGTC_1481 3346-2004 36 µM -0.101590019215046 0.456922982277332 no 1848 0.459541050986276 603 2770522
SGTC_406 estrone 100 µM -0.102232237633462 0.456662164168674 no 1849 0.459286169934637 594 5870 A steroid.
SGTC_3064 1327-0027 10 µM -0.102708068680854 0.456468931427738 no 1850 0.459097334817143 585 16000455 YPR107C YTH1
SGTC_2255 7941087 197.44 µM -0.102735700916442 0.456457710423186 no 1851 0.459086369156599 588 935561
SGTC_1241 0364-0022 50.8 µM -0.103391422342868 0.456191442751647 no 1852 0.458826159820966 610 4563895
SGTC_3305 9127027 53.8275 µM -0.103845126699615 0.45600721931157 no 1853 0.458646127053782 603 41905295
SGTC_283 0987-0079 11.7 µM -0.104392208317738 0.455785093276669 no 1854 0.458429052880445 587 411556
SGTC_1472 k841-0093 193 µM -0.105116774714713 0.455490926169166 no 1855 0.458141574374298 601 X1472
SGTC_2476 5806916 10.51 µM -0.105889405124049 0.455177272413008 no 1856 0.457835050146039 604 2870194
SGTC_683 panaxydol 45 µM -0.106636245808045 0.454874114697697 no 1857 0.457538781260898 594 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.107657472781735 0.454459620617469 no 1858 0.457133702589807 587 6708514
SGTC_1693 xanthone 101.9 µM -0.107674936146751 0.454452533042871 no 1859 0.457126775978394 611 7020 An insecticide.
SGTC_2879 9041815 71.43 µM -0.10855191230891 0.454096627554607 no 1860 0.456778951844466 597 4942971
SGTC_1736 st036774 51 µM -0.108595339127325 0.454079004492722 no 1861 0.456761728864499 606 1272247
SGTC_3008 9078912 71.4286 µM -0.110792723241057 0.453187401561203 no 1862 0.455890357919303 621 16648731
SGTC_1946 st076057 65.1 µM -0.112486798403775 0.452500180342705 no 1863 0.455218718327587 598 953009
SGTC_2618 avocadyne 43.43 µM -0.113427437481065 0.452118660498634 no 1864 0.454845844056172 596 3015189
SGTC_2726 cimetidine 79.27 µM -0.113512768270062 0.452084052817885 no 1865 0.454812020446377 598 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1643 st009866 20.2 µM -0.116626719078511 0.450821376312668 no 1866 0.453577931723444 589 3156273 YOR207C RET1
SGTC_830 4076-0286 57.8 µM -0.117362431632913 0.450523124274663 no 1867 0.453286426749016 598 6866659
SGTC_3081 9117243 49.47 µM -0.117475392743516 0.450477333205675 no 1868 0.453241671377503 604 45595589
SGTC_3208 9114115 49.47 µM -0.118929187866538 0.449888067021617 no 1869 0.452665728645787 611 650895
SGTC_1845 st056753 3.01 µM -0.119524813937808 0.449646673978488 no 1870 0.452429791134726 603 5375839
SGTC_1268 0828-0275 2.46 µM -0.12124540413307 0.448949464764627 no 1871 0.451748331032258 622 745337
SGTC_1903 st060211 78.3 µM -0.12153464959364 0.448832273538511 no 1872 0.451633785848147 588 688960
SGTC_1826 st055655 41.6 µM -0.12200574346211 0.448641413835725 no 1873 0.451447234815047 595 676168
SGTC_3334 9142812 21.919 µM -0.122897938024889 0.448279981348379 no 1874 0.45109395923373 610 45283678
SGTC_1670 st016595 4.04 µM -0.124289870629362 0.447716188315239 no 1875 0.450542883590041 596 597879
SGTC_1527 coumarin 137 µM -0.125029601734644 0.447416608061624 no 1876 0.450250057709396 654 323 A hepatotoxic, DNA x-linker.
SGTC_872 0588-0139 234 µM -0.126291721330092 0.446905537469793 no 1877 0.449750504605896 592 2047100
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.126517999715897 0.446813919768169 no 1878 0.449660950909317 617 4213774
SGTC_2424 5537928 59.2 µM -0.126559466216955 0.446797130732387 no 1879 0.449644540081675 606 5382802
SGTC_2231 micatex 6.853 µM -0.130918037358429 0.445032961676326 no 1880 0.447920072871575 608 20737 An antifungal of unknown mechanism.
SGTC_2888 9058547 12.99 µM -0.131387011496527 0.444843204591318 no 1881 0.447734581458601 608 16476514
SGTC_2402 5553605 200 µM -0.132561895749861 0.444367876586105 no 1882 0.447269934589402 630 6758546
SGTC_2167 5876490 200 µM -0.132864090129986 0.444245629406007 no 1883 0.447150433492917 603 686534
SGTC_2300 7976697 71.57 µM -0.133472834226957 0.443999389290023 no 1884 0.446909723584403 595 2236109
SGTC_1212 0520-0165 585 µM -0.134780760288144 0.443470399715328 no 1885 0.446392609042932 685 5403258
SGTC_3299 9121982 43.1275 µM -0.134986739210737 0.443387100872799 no 1886 0.446311179471037 623 17594604 YPL160W CDC60
SGTC_2201 6605497 169.863 µM -0.135473158832983 0.44319040043167 no 1887 0.446118892372666 611 670741
SGTC_1678 st019265 80.2 µM -0.135839535972121 0.443042252522156 no 1888 0.44597406776953 639 5367020
SGTC_3163 9099914 49.47 µM -0.136574084127246 0.442745255337976 no 1889 0.445683731194829 602 16268368
SGTC_3137 9097352 49.47 µM -0.137529627751645 0.44235895202808 no 1890 0.445306087840718 606 44120435
SGTC_1935 st074532 41.6 µM -0.137807064689495 0.442246801194963 no 1891 0.445196450410452 628 2829742
SGTC_893 0958-0369 48.9 µM -0.139281590011078 0.441650818425388 no 1892 0.444613818559305 619 6819948
SGTC_410 α-linolenic acid 100 µM -0.139718758817255 0.441474146155677 no 1893 0.444441102198803 605 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1615 st002656 86.5 µM -0.140383233857227 0.441205635324145 no 1894 0.44417860205672 594 1584458
SGTC_2111 5486399 200 µM -0.141323364457102 0.440825779738158 no 1895 0.443807246340748 616 689674
SGTC_1382 3002-2117 298 µM -0.141346561217483 0.440816407877092 no 1896 0.443798084140871 619 1497314
SGTC_2873 9040596 71.43 µM -0.142744351582871 0.44025173964824 no 1897 0.443246043929943 612 6463863
SGTC_76 0433-0009 400.328 µM -0.144162092534592 0.439679136048797 no 1898 0.44268623698896 682 2841569
SGTC_1600 coumarin 106 71.1 µM -0.145451727581253 0.439158381985245 no 1899 0.442177113078413 653 100336 A hepatotoxic, DNA x-linker.
SGTC_592 k241-0073 46.5 µM -0.145623692129363 0.439088950712246 no 1900 0.442109231873352 609 4230158
SGTC_125 0133-0007 11.75 µM -0.146333658048086 0.438802319413385 no 1901 0.441828998277422 613 26541
SGTC_750 4073-0104 132 µM -0.146423233744114 0.438766157703383 no 1902 0.44179364354788 620 22330957
SGTC_2752 diclazuril 33.15 µM -0.147172731872562 0.438463605355527 no 1903 0.441497841509749 629 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2064 5220758 200 µM -0.147669241865307 0.438263197341369 no 1904 0.441301903448996 613 788518
SGTC_745 0469-0705 296 µM -0.148443594536555 0.437950674360245 no 1905 0.440996348842198 635 3486736
SGTC_1117 retinoic acid 1.10837 µM -0.149107407859452 0.437682795036855 no 1906 0.440734440306166 608 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_936 3005-4620 401 µM -0.153230921558103 0.436019411279349 no 1907 0.439108086865461 626 777207
SGTC_3101 9120531 49.47 µM -0.153293217419951 0.435994290357109 no 1908 0.439083524587833 668 24824904
SGTC_684 1140-0066 328 µM -0.154898519643937 0.435347038590142 no 1909 0.438450660357554 641 6813534
SGTC_2593 nobiletin 86.24 µM -0.155313506003607 0.43517974576467 no 1910 0.438287084282396 613 72344 An anti-infammatory.
SGTC_20 0481-0013 4.944 µM -0.155384744887389 0.435151028506802 no 1911 0.438259004956254 615 182045
SGTC_2328 6201408 200 µM -0.15616385590817 0.434836981765316 no 1912 0.437951932977512 644 2890418
SGTC_896 0964-0007 44.5 µM -0.156262125026874 0.43479737402731 no 1913 0.437913204699104 608 6756758
SGTC_1588 farnesol 29.9 µM -0.157773327369091 0.434188360875644 no 1914 0.43731770852928 597 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1732 st034308 51.822 µM -0.159542435764303 0.433475610336119 no 1915 0.436620763775247 601 830119
SGTC_2310 7668677 200 µM -0.159583172962393 0.433459200392809 no 1916 0.4366047175609 618 2197143
SGTC_2678 equilin 100 µM -0.160500021827851 0.433089901561536 no 1917 0.436243602216534 603 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_204 PMA1.184 62.41 µM -0.160923816251326 0.432919220539682 no 1918 0.436076702057022 619 2252213 YGL008C PMA1
SGTC_2450 5739737 12.93 µM -0.161042933486556 0.432871248938094 no 1919 0.436029792950717 604 2262825
SGTC_1631 benzylvanillin 81.9 µM -0.161075867209547 0.432857985847792 no 1920 0.436016823605025 628 75506
SGTC_1766 st045414 44.774 µM -0.162195689582733 0.432407055360915 no 1921 0.435575877035828 606 253960
SGTC_527 4476-4215 268 µM -0.163129169277392 0.432031228660057 no 1922 0.435208366822594 606 4418754
SGTC_604 1000-0114 314 µM -0.163946279670953 0.431702303675699 no 1923 0.434886717030196 638 1572745
SGTC_1149 3909-7961 23.3 µM -0.164157263544609 0.431617380523376 no 1924 0.4348036716942 606 735261
SGTC_1880 MG-132 525 µM -0.166371695487683 0.430726240570251 no 1925 0.433932223617078 625 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1318 1280-3875 124 µM -0.16738901890994 0.430316963422328 no 1926 0.433531982459437 639 373245
SGTC_878 0828-0289 13.7 µM -0.167489172085608 0.430276675058605 no 1927 0.433492583306707 605 745350 YLR208W SEC13
SGTC_202 3594-0513 34.79 µM -0.168280629324774 0.429958323129346 no 1928 0.433181256052182 624 708429
SGTC_2868 9035608 32.47 µM -0.168871427368021 0.429720713051386 no 1929 0.432948887022616 605 6462614
SGTC_1407 3909-7909 12.3 µM -0.169449379058697 0.429488294212744 no 1930 0.432721593071797 607 4411780
SGTC_1490 4089-0339 670 nM -0.169478080286985 0.429476752870263 no 1931 0.43271030617578 644 742542
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.169928567386231 0.429295610830535 no 1932 0.432533157157485 617 94937 An inhibitor of serotonin biosynthesis.
SGTC_2861 9024595 19.48 µM -0.170193052335819 0.429189267674833 no 1933 0.432429157721828 606 16482810
SGTC_3296 9122258 64.045 µM -0.170320486887735 0.429138031083433 no 1934 0.432379050221861 649 4730474
SGTC_3228 9131799 49.47 µM -0.170394062086311 0.429108449835194 no 1935 0.432350120813757 622 17015818
SGTC_2260 7964312 200 µM -0.171334845301757 0.428730238750033 no 1936 0.431980241476664 645 231951
SGTC_485 niflumic acid 177 µM -0.17200003326115 0.428462861182935 no 1937 0.431718751424728 634 4488 A COX2 inhibitor.
SGTC_1989 st071868 50.2 µM -0.17263095278847 0.428209288421151 no 1938 0.4314707601759 623 16414057
SGTC_1408 3909-7976 48.8 µM -0.173331430014739 0.427927794462193 no 1939 0.431195459998856 627 24152374
SGTC_314 1671-0008 2.74 µM -0.173837365003461 0.427724502100277 no 1940 0.430996639209065 645 3913060
SGTC_2708 st078559 56 µM -0.174265065884259 0.427552660353802 no 1941 0.430828576257448 610 17250902
SGTC_3131 9127911 49.47 µM -0.174400213053872 0.427498363752465 no 1942 0.430775473446623 663 45595681
SGTC_2736 butenafine 14.65 µM -0.174583239831405 0.427424833273587 no 1943 0.430703559497614 618 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2504 purpurogallin 52.29 µM -0.174783864610571 0.427344235744744 no 1944 0.430624733671431 617 5281571 An antioxidant.
SGTC_1834 st055981 52.8 µM -0.175627040787238 0.427005537516419 no 1945 0.430293478533914 657 471719 YDL150W RPC53
SGTC_2308 7584454 197.62 µM -0.176160256836919 0.426791375953386 no 1946 0.430084021452582 661 893577
SGTC_613 3914-0030 117 µM -0.1770195713635 0.426446285226096 no 1947 0.429746508311054 614 1145395
SGTC_3262 9137218 49.47 µM -0.178037783406274 0.426037456005428 no 1948 0.429346651432997 616 17650664
SGTC_2347 9049783 174.81 µM -0.178798861064693 0.425731922437712 no 1949 0.429047819805785 669 6467988 YPL169C MEX67
SGTC_3006 9075424 71.4286 µM -0.179087417909945 0.425616093340114 no 1950 0.428934530673496 625 7465181
SGTC_723 4182-0001 115 µM -0.179828154993671 0.425318784775939 no 1951 0.428643739717235 634 744821 YLR208W SEC13
SGTC_1850 st056238 17 µM -0.180933723419179 0.424875123421302 no 1952 0.428209799112268 630 5393177
SGTC_2951 9072950 58.06 µM -0.181213623829268 0.42476281528139 no 1953 0.42809995068434 615 16488155
SGTC_2197 6588183 93.1375 µM -0.181309488165242 0.424724351770734 no 1954 0.428062329488315 626 884136
SGTC_3111 9122088 49.47 µM -0.182344951483975 0.424308940056418 no 1955 0.427656011891831 644 16876704
SGTC_3216 9129716 49.47 µM -0.182395018039101 0.424288856263415 no 1956 0.427636367629863 619 8056934
SGTC_3133 9127736 49.47 µM -0.183536894463396 0.42383085525982 no 1957 0.42718838640705 642 27243420
SGTC_3180 9109287 49.47 µM -0.184196219913251 0.423566449879446 no 1958 0.426929762409348 619 18891271
SGTC_2492 derrusnin 100 µM -0.184561455202721 0.423419996537867 no 1959 0.426786510389144 641 1715307 Part of coumarin class of compounds.
SGTC_1353 1498-1206 8.11 µM -0.18527000402869 0.423135910304117 no 1960 0.426508632017917 630 6756808
SGTC_1749 st037932 54.2 µM -0.186136210303953 0.422788667044101 no 1961 0.42616897318272 650 594497
SGTC_1573 oleylamine 1.06 µM -0.187319903416174 0.422314247257172 no 1962 0.425704909257351 651 5356789 An amine of the fatty acid oleic acid.
SGTC_3279 9140807 49.47 µM -0.188151070200999 0.421981186009671 no 1963 0.425379113846267 621 45595718
SGTC_1703 st026983 48.3 µM -0.190522015952579 0.421031419118596 no 1964 0.424450046449786 634 1104023
SGTC_3122 9126309 49.47 µM -0.190533663198623 0.421026754528167 no 1965 0.424445483447518 631 17591206
SGTC_546 peri-Naphthalide 147 µM -0.19213549581876 0.420385344543925 no 1966 0.423818035607862 624 223824 A penicillin ester.
SGTC_3099 9120367 49.47 µM -0.192512291340131 0.420234497743207 no 1967 0.42367047044243 633 24824940
SGTC_2698 st077697 67.5 µM -0.193496322341185 0.419840604818186 no 1968 0.423285142990067 624 3154499
SGTC_2807 7945238 51.95 µM -0.194007126297048 0.419636169248215 no 1969 0.423085150971304 667 17148797
SGTC_47 0149-0135 24.25 µM -0.194954829798073 0.419256933850092 no 1970 0.422714154817266 628 5239155
SGTC_814 3342-0569 96 µM -0.194976702575234 0.41924818206909 no 1971 0.422705593119964 625 4346283
SGTC_1337 1486-1011 40.3 µM -0.195466029420283 0.419052402048577 no 1972 0.42251406465737 627 X1337
SGTC_1808 st050063 61.5 µM -0.195731042183314 0.418946378616445 no 1973 0.422410343091507 651 4011993
SGTC_2852 9023854 51.95 µM -0.196165777914228 0.418772467011567 no 1974 0.422240206447772 646 19798528
SGTC_2819 7996655 46.38 µM -0.19698248395383 0.418445795018099 no 1975 0.421920622504976 655 6456960
SGTC_687 k029-0044 34.9 µM -0.197140691945241 0.418382520336063 no 1976 0.421858720324817 636 5829338
SGTC_3050 9093513 49.47 µM -0.197343695707357 0.418301332850446 no 1977 0.421779293692224 628 25236664
SGTC_1730 st033808 45.1 µM -0.198237936320019 0.417943739842349 no 1978 0.421429453760489 619 1045166
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.198312533983476 0.417913912450119 no 1979 0.421400272868303 665 165506
SGTC_3267 9137951 49.47 µM -0.198798493701651 0.417719616170855 no 1980 0.421210187163692 615 16643986
SGTC_1484 3473-2379 286 µM -0.198820088228977 0.417710982718668 no 1981 0.421201740776339 633 671917
SGTC_2640 pentamidine 10.38 µM -0.199326723427478 0.417508442290554 no 1982 0.421003588152527 647 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1082 camptothecin 424.86 nM -0.199547034626063 0.417420374056581 no 1983 0.420917427378505 602 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2695 st077686 51.995 µM -0.199591688678197 0.417402524340657 no 1984 0.420899964235287 636 2876092
SGTC_431 k089-0097 107 µM -0.200460320395973 0.417055337136878 no 1985 0.42056029392526 665 5499420
SGTC_1309 pyrazolanthrone 13.4 µM -0.200696366638616 0.416961001947259 no 1986 0.42046800045836 646 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_865 0488-0499 301 µM -0.203156482436744 0.415978109424253 no 1987 0.419506362742815 642 9634651
SGTC_2718 lomofungin 53.02 µM -0.203430375689095 0.415868712965538 no 1988 0.419399329892978 654 5351222 A RNA synthesis inhibitor.
SGTC_1575 cyproterone acetate 48 µM -0.20566932843996 0.414974691867841 no 1989 0.418524609347049 674 9880 An androgen receptor antagonist and liver toxin.
SGTC_391 gliotoxin 8.33 µM -0.205822076775392 0.414913714947992 no 1990 0.418464947811359 655 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_207 4185-0010 4.486 µM -0.206410535599719 0.414678822188625 no 1991 0.418235120905071 628 3761753
SGTC_3066 9117245 49.47 µM -0.207469514570417 0.414256190676558 no 1992 0.417821599275014 655 17176980
SGTC_1433 4060-0023 7.6 µM -0.207527433746568 0.414233078374563 no 1993 0.417798984981057 625 3840627
SGTC_1115 galangin 695.678 nM -0.208173263335127 0.413975384064476 no 1994 0.417546842017928 675 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1124 fisetin 1.16336 µM -0.209173350975728 0.413576409354536 no 1995 0.417156457550237 666 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_798 1287-0182 476 µM -0.20925287134549 0.413544689341705 no 1996 0.417125420253065 669 1649755
SGTC_68 0986-0284 82.829 µM -0.20941487750483 0.4134800681806 no 1997 0.417062189834904 608 423278 YIL048W NEO1
SGTC_1347 1493-0251 600 nM -0.209686766192902 0.413371622246125 no 1998 0.416956077484965 645 3986378
SGTC_2622 2-methoxyxanthone 59.94 µM -0.210173680591895 0.413177427350408 no 1999 0.416766060313626 625 71034 A hepatoprotective.
SGTC_2173 5763948 167 µM -0.211667268096344 0.412581876150462 no 2000 0.416183312876004 618 2867177
SGTC_1191 1487-1166 10.6 µM -0.211937487872144 0.412474150510375 no 2001 0.416077901880475 642 3955771
SGTC_1991 st073000 8.92 µM -0.212210318566907 0.412365390691886 no 2002 0.415971478506742 660 4301969 YIL048W NEO1
SGTC_1469 k284-2957 126 µM -0.21245142385396 0.412269283326593 no 2003 0.415877435426393 644 23884841
SGTC_1753 st043925 64 µM -0.21273760400598 0.412155215425351 no 2004 0.415765817154348 657 670181
SGTC_3246 9135460 32.98 µM -0.213674108653821 0.411781988075776 no 2005 0.415400601669734 628 41446951
SGTC_1871 st057448 67.3 µM -0.214690009790123 0.411377208900219 no 2006 0.415004506002844 666 691747
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.216960818987753 0.410472761443681 no 2007 0.41411943977239 659 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2987 9018338 71.43 µM -0.218921630183236 0.409692166720984 no 2008 0.41335554834573 657 5055682
SGTC_1501 4491-0275 38.4 µM -0.219237279517463 0.409566540756648 no 2009 0.413232608465818 650 5104718
SGTC_752 1896-0090 130 µM -0.22054305413213 0.409046951466301 no 2010 0.412724122673576 639 772567
SGTC_1564 D-Arginine 115 µM -0.222406929684925 0.408305561598527 no 2011 0.411998558899109 692 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_71 0417-1750 47.813 µM -0.222511537962552 0.40826396148294 no 2012 0.411957846198604 615 6811472
SGTC_3092 9117248 49.47 µM -0.223515578946137 0.40786473195428 no 2013 0.411567129780687 638 17141857
SGTC_1636 st007707 68.9 µM -0.224036806270585 0.407657517804805 no 2014 0.411364331897493 681 403051
SGTC_3232 9132874 49.47 µM -0.224238628597052 0.407577290185563 no 2015 0.411285813705318 679 3784940
SGTC_1812 st052057 4.327 µM -0.22511820817386 0.407227688463409 no 2016 0.410943658216288 644 3645418
SGTC_1134 3477-0009 42.5 µM -0.226098796752019 0.406838026358759 no 2017 0.410562290207254 620 3973534
SGTC_738 1315-0003 72.4 µM -0.2264208768838 0.406710059628899 no 2018 0.410437046051671 695 6251474
SGTC_1079 idarubicin 2.36 µM -0.226473983663604 0.406688960553584 no 2019 0.410416395813618 678 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1963 st076565 50.3 µM -0.22659034333947 0.406642732345398 no 2020 0.410371150952207 637 4914280
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.22696381462934 0.406494365779595 no 2021 0.410225939833684 662 521171
SGTC_2479 5617353 43.85 µM -0.227980343658066 0.406090603799815 no 2022 0.409830760827381 655 2731746
SGTC_2483 5729050 27.16 µM -0.22831168776445 0.40595901657138 no 2023 0.409701969485252 680 2865180
SGTC_467 ro 31-8220 72.8 µM -0.229611387027881 0.405442967567736 no 2024 0.409196878850382 653 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_440 fluspirilene 35.1 µM -0.229766187282159 0.405381514654504 no 2025 0.409136730224328 667 3396 An atypical antipsychotic.
SGTC_2094 5332512 191.667 µM -0.230643428163166 0.405033309925887 no 2026 0.408795913138179 677 755774
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.231946339934629 0.40451628172868 no 2027 0.408289845870192 654 77254
SGTC_413 propylparaben 100 µM -0.232029984964751 0.404483094959274 no 2028 0.408257362306603 656 7175 A pharmaceutical preservative.
SGTC_1519 esterone 74 µM -0.232614968571424 0.404251017713057 no 2029 0.408030201444359 642 698 A steroid.
SGTC_75 0159-0059 199.013 µM -0.233090721038541 0.404062299958482 no 2030 0.407845480010729 625 5377270
SGTC_2995 9067767 71.4286 µM -0.233843961458896 0.403763556132724 no 2031 0.407553059636455 666 11673567
SGTC_1015 4130-4525 82 µM -0.234100809463443 0.403661700080981 no 2032 0.407453358765413 649 1363237
SGTC_2281 7943571 200 µM -0.235024481194746 0.403295461395644 no 2033 0.407094866044597 659 1244024
SGTC_935 2996-0153 430 µM -0.237299557183984 0.402393749063021 no 2034 0.406212202804607 643 23738523
SGTC_3174 9107204 49.47 µM -0.237622058259163 0.402265969649059 no 2035 0.406087120230105 669 3938802
SGTC_2435 5706476 10.6 µM -0.238094323416484 0.402078870468715 no 2036 0.405903968707909 622 5725375
SGTC_1805 st050013 60.3 µM -0.238613843291149 0.401873076114135 no 2037 0.40570251488493 662 4037144
SGTC_3327 9140648 26.9345 µM -0.238647228499668 0.401859852357386 no 2038 0.405689569981624 667 8029710
SGTC_503 tyrphostin 8 294 µM -0.238950642928557 0.401739676184704 no 2039 0.405571927686828 693 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2220 6782180 200 µM -0.239652942178782 0.401461545654341 no 2040 0.405299659280142 674 833803
SGTC_1460 k062-0059 9.15 µM -0.240070107402037 0.401296359951075 no 2041 0.405137953736971 625 1373085
SGTC_2602 kawain 100 µM -0.240994070207251 0.400930559491405 no 2042 0.404779856197059 648 5369129
SGTC_1100 amiodarone 5.07 µM -0.241522987485516 0.400721198152754 no 2043 0.404574901151981 641 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3146 9095609 49.47 µM -0.242424596533573 0.400364379984266 no 2044 0.404225588708536 651 17173999
SGTC_2333 9017922 200 µM -0.242919459033371 0.400168569965492 no 2045 0.404033895437777 638 3163164
SGTC_639 0833-0042 114 µM -0.242938256770957 0.400161132463784 no 2046 0.404026614273532 663 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1081 sertraline 6 µM -0.244168247238802 0.399674553986509 no 2047 0.403550258969497 649 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2444 5485484 36.41 µM -0.246237604875358 0.398856277612132 no 2048 0.402749153525205 695 6790631
SGTC_8 0354-0001 70 µM -0.246921852603624 0.398585806322603 no 2049 0.402484351970566 655 4993152
SGTC_164 4100-3994 89.624 µM -0.247203402656314 0.398474528593183 no 2050 0.402375406037576 658 4615967
SGTC_2418 pentamidine 31.67 µM -0.247545430568285 0.398339359153898 no 2051 0.40224306836802 674 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_617 3770-0098 35 µM -0.248425985160704 0.397991420116174 no 2052 0.401902415182509 667 5962639
SGTC_2301 7769476 200 µM -0.249366535624183 0.397619864125415 no 2053 0.401538634174109 660 977820
SGTC_1439 4092-1168 46 µM -0.249616376116748 0.397521182484314 no 2054 0.401442016551275 655 2886240
SGTC_1420 4'-methoxyflavone 42 µM -0.24964374191922 0.397510373977111 no 2055 0.401431434090016 663 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1050 3232-1156 69.3 µM -0.250920850054148 0.39700604987866 no 2056 0.400937651993069 660 700529
SGTC_529 4076-0302 30.3 µM -0.253168939084774 0.396118708710679 no 2057 0.400068833903965 659 5816522
SGTC_2355 9061122 103.12 µM -0.253357705187573 0.396044225433065 no 2058 0.399995903981959 683 5302957
SGTC_2828 7998861 71.43 µM -0.253410315803228 0.39602346702676 no 2059 0.399975578453486 647 2988188
SGTC_2457 5731572 11.68 µM -0.253489060533755 0.395992397515315 no 2060 0.39994515680562 683 2865357
SGTC_330 1488-0319 80.1 µM -0.253632269061145 0.395935894869499 no 2061 0.399889832255063 648 6846614
SGTC_2400 5203494 178.7 µM -0.254870914813242 0.395447280957551 no 2062 0.399411400586451 638 6777674
SGTC_189 3970-0742 2.116 µM -0.255417328463535 0.395231786999315 no 2063 0.399200394182406 680 2891807
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.255450749930158 0.395218607320521 no 2064 0.39918748890151 687 688751
SGTC_1607 st000305 50.6 µM -0.256098378190581 0.39496324028261 no 2065 0.398937437126564 695 5457690
SGTC_2644 guaiazulene 100 µM -0.256486393218742 0.394810263238729 no 2066 0.398787642883624 668 3515 A coloring agent.
SGTC_471 1-acyl-paf 4 µM -0.256491180528992 0.394808375916743 no 2067 0.398785794822706 645 16759367
SGTC_1150 3909-7983 10.9 µM -0.256882352090489 0.394654171008732 no 2068 0.398634797266473 658 23965914
SGTC_2020 4017018 200 µM -0.257766998880261 0.394305492662758 no 2069 0.39829336753285 684 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2780 5215298 71.43 µM -0.258447053805008 0.394037510553665 no 2070 0.398030953011282 697 2834131
SGTC_1779 st039427 55 µM -0.258807035138272 0.393895676782324 no 2071 0.397892064759504 693 1124498
SGTC_3112 9123419 49.47 µM -0.260688431491366 0.393154630118629 no 2072 0.397166394003441 672 17015854
SGTC_567 1080-0542 68.4 µM -0.262360244856652 0.392496458867839 no 2073 0.396521859708698 643 5950415
SGTC_1691 st019933 84.6 µM -0.264566265997022 0.391628447552207 no 2074 0.395671805079121 684 6176082
SGTC_1352 1496-0991 99 µM -0.264895852584924 0.391498810093729 no 2075 0.395544846701069 693 3000039
SGTC_2071 5230951 39.92 µM -0.265040797937128 0.391441802039602 no 2076 0.395489016545304 646 1799272
SGTC_2605 digitonin 300 nM -0.266402226977199 0.390906456121912 no 2077 0.394964725151003 655 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1821 st053465 65.6 µM -0.267220477658737 0.390584800078705 no 2078 0.394649705179528 676 675086
SGTC_2673 kobusone 100 µM -0.268316935093334 0.390153897786752 no 2079 0.394227685845591 653 6710676 An epoxy ketone and protein crosslinker.
SGTC_2259 7964009 200 µM -0.268715685519354 0.389997224291557 no 2080 0.39407424015784 662 313134
SGTC_2184 6075246 200 µM -0.269449286877899 0.38970903081947 no 2081 0.393791981316615 640 2267320
SGTC_852 0418-0143 439 µM -0.269550112054331 0.38966942663489 no 2082 0.393753192401494 674 5369229
SGTC_1933 st074711 15.9 µM -0.269891699580546 0.389535259385032 no 2083 0.393621786538532 651 17250958
SGTC_359 0081-0058 15.9 µM -0.270956664357111 0.389117051762954 no 2084 0.393212181322602 690 3494159
SGTC_2729 fluphenazine 10.66 µM -0.27106237696141 0.389075545823676 no 2085 0.393171528733848 662 3372 An atypical antipsychotic.
SGTC_1770 st043884 66.3 µM -0.271244484095831 0.389004048069124 no 2086 0.393101500777506 666 670149
SGTC_2976 9009005 19.48 µM -0.271368051018217 0.38895553614372 no 2087 0.393053985997923 642 2993148
SGTC_1350 1495-0454 146 µM -0.272699758784295 0.388432822524183 no 2088 0.392542010070155 668 1069057
SGTC_2845 9003024 42.97 µM -0.273449681685536 0.388138556304854 no 2089 0.392253783478723 655 2990173
SGTC_2232 chlorophetanol 41.5365 µM -0.273536291429428 0.388104575181691 no 2090 0.392220499552483 672 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1017 4239-0030 168 µM -0.273924322488109 0.38795234265643 no 2091 0.392071389788601 647 1149593
SGTC_2211 7117706 200 µM -0.274060508795848 0.387898918061633 no 2092 0.39201906085707 657 822771
SGTC_1867 st057372 64 µM -0.274662465860488 0.387662801453171 no 2093 0.391787785167203 666 688837
SGTC_31 0508-1974 57.237 µM -0.274711268201494 0.387643660639206 no 2094 0.391769036675393 649 6810525
SGTC_984 1492-0255 2.91 µM -0.275183414562342 0.387458493758977 no 2095 0.391587664259823 693 1585198
SGTC_1788 fluconazole 20 µM -0.275262102135144 0.387427636467407 no 2096 0.391557439153319 697 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_682 0kpi-0099 17 µM -0.276254456908552 0.387038546148348 no 2097 0.391176316673673 682 1714895 YML126C ERG13
SGTC_3291 9121177 71.43 µM -0.278931017750111 0.385989665808437 no 2098 0.390148882059273 683 17015612
SGTC_702 1488-0190 94 µM -0.280772338232741 0.38526857929748 no 2099 0.389442510700896 656 949357
SGTC_2465 5809242 33.21 µM -0.281642927781458 0.384927782309424 no 2100 0.389108660231725 686 2731748
SGTC_1223 0764-0573 147 µM -0.282063147346169 0.38476331687464 no 2101 0.388947545256744 661 1609797
SGTC_3209 9113616 49.47 µM -0.282375720234198 0.384640995616689 no 2102 0.388827715116468 709 16649353
SGTC_249 wiskostatin 11.211 µM -0.282431930992803 0.384618999499025 no 2103 0.388806166886456 663 2775510 A n-wasp and actin depolymerizer.
SGTC_332 4112-0506 40.9 µM -0.28422171964582 0.383918822760559 no 2104 0.3881202358313 664 2790355
SGTC_812 4251-0442 148 µM -0.284396579368814 0.383850436794419 no 2105 0.388053240047506 692 5723007
SGTC_3336 9143619 71.43 µM -0.285820486212093 0.383293695261946 no 2106 0.387507808330579 695 45595730
SGTC_2022 5136654 200 µM -0.287616592304183 0.382591769145889 no 2107 0.386820121255667 703 1713771
SGTC_601 0986-0029 62.9 µM -0.288065000374281 0.382416589359974 no 2108 0.386648491600862 660 24747981
SGTC_987 1497-1013 404 µM -0.28850866843487 0.382243285035941 no 2109 0.386478698017908 690 1676435
SGTC_2962 9082311 13.18 µM -0.289542446630787 0.381839565177231 no 2110 0.386083151237907 665 16459453
SGTC_1413 3910-0535 34.4 µM -0.291395315522314 0.381116288805412 no 2111 0.38537449842609 673 2876951
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.292352243550887 0.380742909691536 no 2112 0.385008659017169 655 17037758
SGTC_1137 ixabepilone 100 µM -0.292705035070884 0.380605283673437 no 2113 0.384873810473863 644 154225 A novel microtubule stabilizer.
SGTC_843 0310-0051 143 µM -0.294668824635551 0.379839474543809 no 2114 0.384123440299594 675 2065037
SGTC_355 1311-2252 105 µM -0.294678719249232 0.379835617181175 no 2115 0.384119660633437 662 5338538
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.295275729006925 0.379602898232429 no 2116 0.383891627912928 688 1377
SGTC_1424 4048-1941 275 µM -0.296287341440681 0.379208663589502 no 2117 0.383505326133695 697 X1424
SGTC_835 0312-0010 67.2 µM -0.297066631781654 0.378905052610394 no 2118 0.383207819502994 691 1626196
SGTC_1316 1272-0050 65.9 µM -0.297163047859715 0.378867494162137 no 2119 0.38317101589716 694 7340392
SGTC_1709 st033179 39.1045 µM -0.297623628053259 0.378688093013739 no 2120 0.382995219402613 675 573381
SGTC_3198 9112019 49.47 µM -0.298560166139582 0.378323381576735 no 2121 0.382637831328472 720 45595555
SGTC_208 k072-0098 12.366 µM -0.301720795131023 0.377093355093114 no 2122 0.381432457210965 704 5948901
SGTC_2421 5690543 90.72 µM -0.302223145187035 0.376897969255988 no 2123 0.381240980704152 712 3397993
SGTC_2171 5739187 198.077 µM -0.306807382402459 0.375116421659302 no 2124 0.379494994377657 667 2262761
SGTC_474 dl-dihydrosphingosine 5 µM -0.308374930666575 0.374507842337307 no 2125 0.378898527759661 671 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3130 9127414 49.47 µM -0.308866321728552 0.374317130692543 no 2126 0.378711608196039 675 1494646
SGTC_2034 5197015 53.07 µM -0.309066697001735 0.374239372741045 no 2127 0.378635395863982 731 780676
SGTC_2469 5655019 90.81 µM -0.310313579147823 0.373755620722718 no 2128 0.378161252918642 693 2788239
SGTC_3338 9144300 39.5675 µM -0.310978840633913 0.373497600960249 no 2129 0.377908353692987 691 4901274
SGTC_818 4072-2707 53.5 µM -0.311995609702878 0.373103359574367 no 2130 0.377521929936666 667 882871
SGTC_2005 4024620 188 µM -0.312324952226037 0.372975688977226 no 2131 0.377396789355432 696 236743
SGTC_2293 7624732 200 µM -0.313556241299854 0.372498499812347 no 2132 0.376929049429176 680 894453
SGTC_3048 9093155 49.47 µM -0.315413612849823 0.371779041193985 no 2133 0.376223816196432 665 25236002
SGTC_1355 1499-0035 1.68 µM -0.315873242098539 0.371601071366596 no 2134 0.376049361296406 692 1548538
SGTC_2394 5221648 200 µM -0.317708422211175 0.370890757964008 no 2135 0.375353060995166 698 788586
SGTC_1263 0774-1208 64.8 µM -0.319173064338122 0.370324178067903 no 2136 0.374797640573966 730 906585
SGTC_3182 9108849 49.47 µM -0.319418918009724 0.370229099945013 no 2137 0.374704433555191 678 17133045
SGTC_3200 9114385 49.47 µM -0.319498960467612 0.370198147118292 no 2138 0.37467408977146 698 17018030 YLR208W SEC13
SGTC_2731 amoxapine 43.43 µM -0.319527337106273 0.370187173929202 no 2139 0.37466333248468 697 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1335 1486-0900 202 µM -0.321118167320911 0.369572172318747 no 2140 0.374060421632146 658 X1335
SGTC_1786 berberine 21.6 µM -0.322950345298973 0.36886428102562 no 2141 0.373366423686439 695 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1390 3413-2614 145 µM -0.323901960940084 0.368496784376947 no 2142 0.373006129670276 718 3421432
SGTC_2584 androsterone 48.74 µM -0.324923114344192 0.368102567266135 no 2143 0.372619631267151 696 2754130 A steroid.
SGTC_1298 1079-1278 263 µM -0.325161390660455 0.36801060046339 no 2144 0.372529464022059 724 2840950
SGTC_826 1683-5028 118 µM -0.326161864473649 0.367624533174255 no 2145 0.372150946387801 706 722377
SGTC_3285 9112818 20.8695 µM -0.328254075819642 0.366817613988886 no 2146 0.371359782116279 699 17017947 YPR165W RHO1
SGTC_326 k292-0812 17.5 µM -0.328279632053136 0.366807761149304 no 2147 0.37135012144475 708 3579357
SGTC_48 0382-0018 55 µM -0.329558862144455 0.366314684571659 no 2148 0.370866655365762 682 762596
SGTC_96 0929-0093 37.281 µM -0.330263177190958 0.366043301922814 no 2149 0.370600556857185 687 6991579
SGTC_1148 3909-7663 27.7 µM -0.330565953488975 0.365926658474516 no 2150 0.370486183425282 723 4084526
SGTC_827 3253-0474 693 µM -0.330928763181956 0.365786903704418 no 2151 0.370349147517866 716 5402065
SGTC_2415 st077333 57.7 µM -0.331137856961508 0.365706368594591 no 2152 0.370270178721139 656 2766255
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.331626271655578 0.365518272571906 no 2153 0.370085739635542 685 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_432 NS 1619 61.3 µM -0.331883393036584 0.365419264156373 no 2154 0.369988655390906 678 4552 A K+/calcium channel activator.
SGTC_976 1348-1067 47.6 µM -0.332487200025585 0.365186794552229 no 2155 0.369760701697348 673 5310671 YGL099W LSG1
SGTC_2182 6325192 200 µM -0.333071870331773 0.364961739894762 no 2156 0.369540016232051 653 736248
SGTC_885 0865-0106 16.8 µM -0.333423849531517 0.36482627646062 no 2157 0.369407181402104 685 2793380
SGTC_1351 1496-0003 46.5 µM -0.334994407899347 0.364222033982031 no 2158 0.368814652300726 690 3891978
SGTC_1222 0366-0074 1.18 µM -0.336046787697231 0.363817339505051 no 2159 0.368417792233592 717 286520
SGTC_3042 9091578 49.47 µM -0.337128896102738 0.363401371199006 no 2160 0.368009867622663 665 25236497
SGTC_1462 k081-0014 26.5 µM -0.338095316780468 0.36303000997456 no 2161 0.367645679815357 712 3270634
SGTC_17 0960-0276 49.807 µM -0.338115075902186 0.363022418586109 no 2162 0.367638234990442 690 6821114
SGTC_1910 st062352 60.4 µM -0.339067148542429 0.362656699287403 no 2163 0.367279572862558 671 2245730
SGTC_237 nikkomycin 200 µM -0.342547890043098 0.361320711754208 no 2164 0.365969305140907 723 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2095 5432005 200 µM -0.342748982127054 0.361243579518826 no 2165 0.365893654915319 726 783734
SGTC_2612 dictamnine 15.46 µM -0.343276244047437 0.361041366172601 no 2166 0.365695325361979 696 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2225 6654152 15.4 µM -0.343789215703616 0.360844670634241 no 2167 0.365502405538268 712 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2044 5102272 200 µM -0.344796983657478 0.36045835598394 no 2168 0.365123500438295 685 592666
SGTC_1019 4262-0212 3.4 µM -0.34495144735244 0.360399156924679 no 2169 0.365065436113841 704 4677213
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.345005808849264 0.360378323378553 no 2170 0.365045001862831 692 279621
SGTC_1526 st051518 75 µM -0.346233889100481 0.359907783432875 no 2171 0.364583474044968 694 673993
SGTC_1798 st045719 60.953 µM -0.346441612538755 0.359828214993779 no 2172 0.364505428378909 695 3980186
SGTC_448 monastrol 171 µM -0.347215159614718 0.35953196133006 no 2173 0.364214841380594 707 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2343 7990716 14.84 µM -0.347853658295007 0.359287492183481 no 2174 0.363975044801284 675 6456862
SGTC_2943 9068529 45.32 µM -0.347904460890804 0.359268043296543 no 2175 0.363955967504112 687 3270634
SGTC_1326 1431-2094 10.8 µM -0.348468301876461 0.359052211111313 no 2176 0.363744257623769 719 616278
SGTC_1058 3448-5425 97.3 µM -0.348964480405044 0.358862316583367 no 2177 0.36355798791032 707 7279705
SGTC_1086 cerivastatin 2.18 µM -0.349526693611025 0.358647191801143 no 2178 0.363346967182823 685 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2734 clemastine 41.6 µM -0.349975855457247 0.358475357112442 no 2179 0.36317840886926 704 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1900 st060200 72.8 µM -0.352519175399102 0.357502907105387 no 2180 0.362224470189644 674 688945
SGTC_305 1682-2595 20.8 µM -0.353858477658514 0.356991189933599 no 2181 0.36172247311956 710 226033
SGTC_2809 7964133 12.99 µM -0.355159224928651 0.356494449900487 no 2182 0.361235154897137 723 1253665
SGTC_2471 5466956 24.79 µM -0.356219889530107 0.3560895746719 no 2183 0.360837948964411 704 724419
SGTC_2924 9010168 62.78 µM -0.358016374139487 0.355404193624982 no 2184 0.36016552993024 700 2993929
SGTC_805 3852-0218 479 µM -0.358814454503344 0.355099865915441 no 2185 0.359866949322809 708 6615355
SGTC_996 3970-0799 1.8 µM -0.359527613603176 0.354827998948878 no 2186 0.35960021207869 680 6615648 YGL040C HEM2
SGTC_2806 7952793 58.44 µM -0.36084481907676 0.354326054842641 no 2187 0.359107728038381 692 2972490
SGTC_3114 9122766 49.47 µM -0.361261830581461 0.354167198013375 no 2188 0.358951862216742 692 17176985
SGTC_722 3534-0461 190 µM -0.362774287051584 0.353591254246211 no 2189 0.358386750604219 692 658262
SGTC_394 menadione 8.33 µM -0.36282500315513 0.353571947340424 no 2190 0.358367806492428 724 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2257 7960413 200 µM -0.363466573288594 0.353327743172072 no 2191 0.358128189322246 695 2974689 YIL048W NEO1
SGTC_961 1252-1571 372 µM -0.36356967606829 0.353288504254412 no 2192 0.358089687132941 740 6813498
SGTC_1437 4092-1038 11.6 µM -0.365275794743779 0.352639415295363 no 2193 0.357452772465968 707 3977136
SGTC_428 3448-4153 16.5 µM -0.365352602674617 0.352610203965853 no 2194 0.357424108461507 688 3834874
SGTC_3124 9127567 49.47 µM -0.365436246308855 0.352578393893579 no 2195 0.357392894351126 722 17592030
SGTC_480 am 92016 50 µM -0.365985236766819 0.352369635805808 no 2196 0.357188045920417 754 2129 K+ channel blocker.
SGTC_1027 k015-0025 8.67 µM -0.367285698103376 0.351875302326771 no 2197 0.356702960510875 691 3598955
SGTC_773 4358-1457 44.6 µM -0.367483997761439 0.351799946309374 no 2198 0.356629013041833 747 1186886
SGTC_2214 7179297 48.276 µM -0.369410635288667 0.351068106636496 no 2199 0.355910835961085 682 769744
SGTC_1722 st034304 3.6505 µM -0.369448502029304 0.351053728352065 no 2200 0.355896725795026 704 4036148 YLR033W RSC58
SGTC_1001 4048-4355 44.4 µM -0.369949647576722 0.350863459734958 no 2201 0.355710004084855 727 21824233
SGTC_2534 helenine 20.12 µM -0.370325791749905 0.350720674624861 no 2202 0.355569879347761 699 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2250 alverine citrate 130 µM -0.3705747387574 0.350626185416431 no 2203 0.355477150017942 698 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3351 9150312 21.596 µM -0.371348624982931 0.350332511668197 no 2204 0.355188942713608 705 4904905
SGTC_1333 1482-0047 286 µM -0.372894451286573 0.349746170642859 no 2205 0.354613500948953 733 3811116
SGTC_625 k213-0058 121 µM -0.373469446517803 0.34952816288531 no 2206 0.354399540577297 689 3655420
SGTC_1013 4112-3890 241 µM -0.375325687883672 0.348824713382161 no 2207 0.353709132026243 705 705171
SGTC_1473 k844-0725 134 µM -0.376716757841016 0.348297887575477 no 2208 0.353192053939626 688 54682906
SGTC_3293 9120939 62.045 µM -0.377064661975153 0.348166175067918 no 2209 0.353062775939663 744 934087
SGTC_1434 4073-0095 163 µM -0.377807106106136 0.347885155505458 no 2210 0.352786947204815 722 24133745
SGTC_1042 0350-0096 82 µM -0.378036040036113 0.347798519481506 no 2211 0.35270191053664 694 3122515
SGTC_3051 9093778 49.47 µM -0.378127893597262 0.347763761348454 no 2212 0.352667793936893 723 17217378
SGTC_2028 5153890 36.43 µM -0.378623440950885 0.347576264285616 no 2213 0.352483756296913 722 2830968 YPR165W RHO1
SGTC_171 k064-0041 9.68 µM -0.378652395750585 0.347565309996802 no 2214 0.352473004056825 683 53325
SGTC_139 0099-0334 718.624 µM -0.379128070318908 0.347385369231456 no 2215 0.352296381237461 713 97690
SGTC_768 0384-0033 77.3 µM -0.379747749458367 0.347151005219262 no 2216 0.352066335829248 725 3965305 YMR134W ERG29
SGTC_3314 9135860 59.4275 µM -0.380536712794134 0.34685270213293 no 2217 0.351773524862189 700 25252478
SGTC_1702 st027038 51 µM -0.380788384656023 0.346757566218403 no 2218 0.351680139409513 712 5521182
SGTC_517 1365-0151 113 µM -0.383407643333359 0.345768019843138 no 2219 0.350708768496922 720 768657
SGTC_1468 k284-1086 134 µM -0.384129195398409 0.345495604759495 no 2220 0.350441346777379 713 15996457
SGTC_762 1165-0429 115 µM -0.384508374836588 0.345352481245991 no 2221 0.350300844943375 745 5967793
SGTC_2423 st077119 87.2 µM -0.385275295592015 0.345063070091165 no 2222 0.350016731370709 690 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_226 1,3-diallylurea 8.28947 mM -0.385309031880638 0.345050341183333 no 2223 0.350004235346721 720 74537 YKL182W FAS1
SGTC_2464 5717415 7.67 µM -0.385364115455546 0.345029558190799 no 2224 0.34998383257205 713 5285744
SGTC_1457 k015-0032 57.3 µM -0.385914006852222 0.344822110204911 no 2225 0.34978017836106 731 4302660
SGTC_1876 myriocin 605 nM -0.388016411036114 0.34402940320239 no 2226 0.349001944484087 753 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1803 st050068 52.4 µM -0.391142913922703 0.342851829458425 no 2227 0.347845800800947 719 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_947 3447-0010 211 µM -0.392493977142441 0.342343432895586 no 2228 0.347346630317837 727 748350
SGTC_111 0083-0039 52.457 µM -0.394318113595949 0.341657475025743 no 2229 0.346673095851693 698 759313
SGTC_1763 st044482 94.5 µM -0.39465102566431 0.341532341342741 no 2230 0.346550225368161 733 88505
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.395412194445142 0.341246301655708 no 2231 0.346269355465734 720 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_155 k072-0202 43.6 µM -0.396210360933048 0.340946456542208 no 2232 0.345974924263294 724 5857737
SGTC_1852 st056254 31.4 µM -0.396346500936077 0.340895323205522 no 2233 0.345924713623165 716 442583
SGTC_3107 9121808 49.47 µM -0.396523060706855 0.340829012809242 no 2234 0.345859599552725 700 662681
SGTC_3152 9099253 49.47 µM -0.398346799033732 0.340144361093757 no 2235 0.345187284010256 731 25236131
SGTC_3343 9148379 18.9835 µM -0.398495071999647 0.340088720891523 no 2236 0.345132645071948 736 1955036
SGTC_2900 5328528 85.29 µM -0.399394678386724 0.339751213609261 no 2237 0.344801207241574 695 795359
SGTC_649 1123-0311 367 µM -0.400367161324872 0.339386509533775 no 2238 0.344443053768714 744 693629 YIL048W NEO1
SGTC_2179 6298986 200 µM -0.400528156884961 0.339326146895581 no 2239 0.344383774532912 713 738374
SGTC_1698 5-fluorocytosine 1.055 µM -0.401108279463334 0.339108673675841 no 2240 0.344170202694395 723 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2031 5180455 200 µM -0.401447030725805 0.338981709212201 no 2241 0.344045514561417 718 29949
SGTC_2839 9003951 25.97 µM -0.401555409160317 0.338941092678618 no 2242 0.344005626024904 736 2990634
SGTC_94 0334-0113 514.748 µM -0.401759175607688 0.338864733046979 no 2243 0.343930634759368 705 6795178
SGTC_988 1497-1057 103 µM -0.403365290035984 0.338263088189606 no 2244 0.343339758663628 755 3533044
SGTC_2499 avocadenofuran 51.48 µM -0.403415613045273 0.338244244026788 no 2245 0.343321251424641 735 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1555 citronellol 128 µM -0.404146951538526 0.337970429733873 no 2246 0.343052330280057 731 8842 A terpine precursor.
SGTC_3306 9127676 59.7925 µM -0.40415103960499 0.337968899396051 no 2247 0.343050827276657 695 41905287
SGTC_1947 st076332 61.6 µM -0.404469578900608 0.3378496647728 no 2248 0.342933721933952 728 24208416
SGTC_2352 9027995 87.8 µM -0.405369496887046 0.337512898255247 no 2249 0.342602964540781 713 2997347
SGTC_2144 5628481 200 µM -0.406230044232503 0.337190986655822 no 2250 0.342286790333947 706 2818399
SGTC_312 4092-0653 6.84 µM -0.407787439621508 0.336608702827929 no 2251 0.341714867883006 714 1148278
SGTC_577 r071-0003 38.6 µM -0.408371337194264 0.336390494229216 no 2252 0.341500536649252 708 4568517 YMR134W ERG29
SGTC_1669 st015249 58.4 µM -0.40988526296443 0.335824981189237 no 2253 0.340945058202744 732 722793
SGTC_2165 5727197 32.143 µM -0.40996165104666 0.335796456959886 no 2254 0.340917039575756 731 1361712
SGTC_3000 9075062 71.4286 µM -0.412170687682217 0.334971985881226 no 2255 0.34010716014312 713 17057871
SGTC_3049 9092223 49.47 µM -0.412383410965502 0.334892633792626 no 2256 0.340029210153362 746 8623917
SGTC_1712 st032288 53.4 µM -0.41299971812094 0.33466277458321 no 2257 0.339803410129327 735 2883011
SGTC_1237 0330-0133 46.1 µM -0.413164944121161 0.334601162073978 no 2258 0.339742885087449 748 X1237 YHR072W ERG7
SGTC_2945 9067681 61.76 µM -0.416397688645434 0.33339657465309 no 2259 0.338559509750243 759 16456930
SGTC_1402 3909-7673 35.9 µM -0.416407813769686 0.333392804512097 no 2260 0.338555805852438 703 5328014
SGTC_1512 0259-0544 12.2 µM -0.419164542974198 0.33236694972637 no 2261 0.337547941624424 695 18476
SGTC_770 0389-1121 67.2 µM -0.419410716055227 0.332275402855314 no 2262 0.337457996902883 712 6753108
SGTC_3256 9138902 49.47 µM -0.419931849370423 0.332081636763401 no 2263 0.337267620085592 746 17228773
SGTC_858 0438-0351 2.77 µM -0.419987123382405 0.332061087592588 no 2264 0.337247430208725 716 2799119
SGTC_733 4069-0007 56.1 µM -0.421995778988807 0.331314674547991 no 2265 0.336514049206039 723 5717425 YNL287W SEC21
SGTC_2850 9015429 58.44 µM -0.423284182237979 0.330836258359464 no 2266 0.336043966771154 734 6457570
SGTC_470 aa-861 153 µM -0.424257590888221 0.330474990587448 no 2267 0.33568898212572 708 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_233 rapamycin 362 pM -0.42570234475864 0.329939080457309 no 2268 0.335162376640577 725 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2349 9023730 187.07 µM -0.426541578361347 0.329627939229273 no 2269 0.334856628841117 746 4126287
SGTC_2965 9082772 38.63 µM -0.428653315685457 0.328845546174851 no 2270 0.33408776969276 707 16459634
SGTC_2350 9023895 38.85 µM -0.428900523638692 0.328754005223026 no 2271 0.333997809565686 714 2997209
SGTC_912 3474-0017 2.18 µM -0.430124432463593 0.328300943973963 no 2272 0.333552564026997 761 3360550
SGTC_2540 epiandrosterone 100 µM -0.43113407984875 0.327927387046764 no 2273 0.333185440976491 725 441302 A steroid.
SGTC_1177 0983-0204 23.6 µM -0.432619174492232 0.327378233360031 no 2274 0.332645728544867 730 766818
SGTC_3194 9111903 49.47 µM -0.433046172149234 0.327220408545422 no 2275 0.332490613366815 767 17087251
SGTC_2557 derrustone 83.84 µM -0.433240372382973 0.327148639407828 no 2276 0.332420075853094 778 629853 An antioxidant.
SGTC_1961 st076550 68.7 µM -0.433514173368126 0.327047463669378 no 2277 0.332320635793663 734 1579337
SGTC_2936 9038235 15.59 µM -0.434323312152769 0.326748542650028 no 2278 0.33202683876207 720 4749415
SGTC_449 xestospongin c 11.1929 µM -0.435464591646503 0.326327107540596 no 2279 0.331612617482387 745 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2594 a-mangostin 100 µM -0.435968293008661 0.326141178481338 no 2280 0.331429867206873 761 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_626 0214-0009 33 µM -0.437436685140598 0.325599404098044 no 2281 0.33089734204146 749 3437874
SGTC_651 3253-0966 34.4 µM -0.438582277626661 0.325176984697942 no 2282 0.330482120377797 728 781462
SGTC_1028 k015-0029 4.8 µM -0.438724766742502 0.325124459746566 no 2283 0.33043048956577 745 4588309
SGTC_1122 capsaicin 818.572 nM -0.438792910404636 0.32509934156464 no 2284 0.330405798907548 755 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1700 st030840 7.9285 µM -0.439690851160055 0.32476842924121 no 2285 0.330080514852227 730 5499307
SGTC_2086 5274770 176.623 µM -0.440034331790803 0.324641885076516 no 2286 0.329956121015474 732 689278
SGTC_2565 isoliquiritigenin 100 µM -0.440077133609483 0.324626117569165 no 2287 0.329940621364018 706 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1046 2001-0062 216 µM -0.440188736904758 0.324585006173406 no 2288 0.329900208282072 737 739778
SGTC_2389 9091542 195.52 µM -0.440235583499699 0.324567749892339 no 2289 0.329883245079902 725 3626624 YOL127W RPL25
SGTC_284 0988-0104 32.6 µM -0.440788412224855 0.324364139899341 no 2290 0.329683091638276 740 4666532
SGTC_1516 st013856 110 µM -0.442170025392487 0.323855513504615 no 2291 0.329183087432499 747 5281404 A mutagen and neurotoxin.
SGTC_2958 9077254 16.72 µM -0.444501061030057 0.322998112748557 no 2292 0.328340180956136 738 16457351
SGTC_1750 st081859 2.357 µM -0.444628629299576 0.322951217710918 no 2293 0.328294077211098 747 5291695
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.444801705755742 0.322887598027735 no 2294 0.328231530783927 736 66535 A nucleotide analog.
SGTC_1660 st012960 28.1 µM -0.445787140059093 0.322525469523828 no 2295 0.327875506004371 760 24207266
SGTC_2348 9022543 33.42 µM -0.446882118238547 0.32212328311844 no 2296 0.327480087843201 729 3162678 YDL140C RPO21
SGTC_1591 genipin 88.4 µM -0.447019715196873 0.322072758355942 no 2297 0.327430412548289 757 442424 A DNA cross-linking agent.
SGTC_569 4130-2812 160 µM -0.448167191911014 0.321651540042781 no 2298 0.327016269218084 763 743552
SGTC_1993 st073995 70.8 µM -0.449059759069198 0.321324052912759 no 2299 0.32669427416795 732 3098394
SGTC_2290 7904846 200 µM -0.449504208438254 0.321161034100431 no 2300 0.326533986447545 718 2962154
SGTC_1105 epirubicin 18.1 µM -0.449781644816942 0.321059291158093 no 2301 0.326433947085958 726 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3178 9107506 49.47 µM -0.453109023148452 0.319840105733242 no 2302 0.325235119148392 734 8897194
SGTC_1431 4049-0260 9.09 µM -0.453353965567144 0.319750432980266 no 2303 0.325146939585031 755 3854841
SGTC_1202 1988-0068 29.6 µM -0.45400023784253 0.319513885035905 no 2304 0.324914327803428 734 2850480
SGTC_2041 5107442 45.335 µM -0.45401399328903 0.319508851078526 no 2305 0.324909377568225 742 793005
SGTC_2930 9013230 14.89 µM -0.454187673128117 0.319445293887046 no 2306 0.324846877272926 739 2995857
SGTC_2419 paclitaxel 166.5 µM -0.455070999232005 0.319122127628443 no 2307 0.324529080541087 752 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1547 harmine 94.2 µM -0.456080207403781 0.318753075397927 no 2308 0.324166151192978 720 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1209 2323-2347 50.3 µM -0.457664600644293 0.318174049205463 no 2309 0.323596712010151 714 5412760
SGTC_2052 5265182 7.135 µM -0.460885737039909 0.31699823539984 no 2310 0.322440292617928 751 1239884
SGTC_447 ml7 120 µM -0.461313439291305 0.316842249474797 no 2311 0.32228687214749 744 4216 Selective myosin light chain kinase inhibitor.
SGTC_1425 4048-4433 7.33 µM -0.46132793619456 0.316836962925668 no 2312 0.322281672514021 778 23734946
SGTC_445 e6 berbamine 66 µM -0.461517096131469 0.316767985876932 no 2313 0.322213829326201 762 6610268 A calcium/calmodulin antagonist.
SGTC_2069 5228469 200 µM -0.466176863875968 0.315070820643538 no 2314 0.32054445424595 767 2835210
SGTC_1813 st051246 8.6015 µM -0.467643681805326 0.314537385680742 no 2315 0.320019710807319 741 5291959
SGTC_3164 9100705 49.47 µM -0.468305960127341 0.314296662867049 no 2316 0.319782903412751 746 17174235
SGTC_320 4092-0846 5.34 µM -0.468967113873724 0.314056427563031 no 2317 0.319546571373986 743 1359356
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.472772734054597 0.312675160362603 no 2318 0.318187664342184 751 5024745
SGTC_2848 9016370 25.97 µM -0.472780784422279 0.312672241222483 no 2319 0.318184792308729 736 7894410
SGTC_3063 1327-0034 4 µM -0.473397256670803 0.312448737417469 no 2320 0.317964893352527 752 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3061 glucosamine 200 µM -0.474954065606553 0.3118846189873 no 2321 0.317409857028145 752 91431 and experimental redox chemotherapeutic
SGTC_547 1120-0019 610 nM -0.476806570281859 0.311213928175255 no 2322 0.316749933343749 749 3676939
SGTC_2105 5350118 200 µM -0.477224998082886 0.311062524939171 no 2323 0.316600956067104 737 2133313
SGTC_2156 5649887 115 µM -0.477519194571519 0.310956092498354 no 2324 0.316496227987013 739 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_113 0099-0221 2.5 µM -0.477710777248053 0.31088679149718 no 2325 0.316428036285761 729 89219
SGTC_1556 plumbagin 1.48 µM -0.479265098082925 0.310324796760518 no 2326 0.315875024118811 759 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1398 3558-0053 112 µM -0.47941161228702 0.310271844525047 no 2327 0.315822917018764 727 4532369
SGTC_2721 ifenprodil 61.44 µM -0.480790495249798 0.309773690187663 no 2328 0.315332703083682 733 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_747 3448-8087 38.7 µM -0.481392924037687 0.309556157963391 no 2329 0.315118632390459 780 5168703
SGTC_2724 maprotiline 69.64 µM -0.482102902690369 0.309299875969277 no 2330 0.314866423965815 756 4011 A tricyclic antidepressant.
SGTC_3168 9103419 49.47 µM -0.483534049429387 0.308783554909557 no 2331 0.314358294698603 765 16649256
SGTC_2680 butyl paraben 22.24 µM -0.484607620534176 0.308396485841727 no 2332 0.31397735351292 769 7184 An antifungal and steroid mimetic.
SGTC_1886 st057356 49.9 µM -0.484887550890056 0.308295593750811 no 2333 0.313878056826948 726 24207747
SGTC_2085 5307070 144.047 µM -0.485070191237089 0.30822977458801 no 2334 0.313813278044696 772 2840351
SGTC_948 3448-0295 75.3 µM -0.485398559464948 0.308111454130346 no 2335 0.313696827009204 747 678569
SGTC_2992 9074591 71.4286 µM -0.485522259950177 0.308066886479941 no 2336 0.313652963236176 763 17741321
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.487349935748952 0.307408729144326 no 2337 0.313005182865203 751 75037 A free radical scavenger.
SGTC_824 1304-0008 100 µM -0.487869875337601 0.307221608809106 no 2338 0.312821006762949 739 768245
SGTC_2702 st077768 96.8 µM -0.488096942510051 0.307139905660283 no 2339 0.312740588327298 725 6484119
SGTC_1708 st033234 31.827 µM -0.488208661247327 0.307099710617235 no 2340 0.312701025129965 745 674664
SGTC_3044 9093193 49.47 µM -0.489254938727092 0.306723385260621 no 2341 0.312330609413703 784 25236277
SGTC_1314 1222-0010 41.1 µM -0.489282008956146 0.306713651334484 no 2342 0.312321028200605 764 3526027
SGTC_1007 4101-0031 70 µM -0.490103586802953 0.306418292846026 no 2343 0.312030300055275 768 1146276
SGTC_1287 0971-0001 34.6 µM -0.491046982613747 0.306079295678908 no 2344 0.311696609089013 733 4665869
SGTC_1003 4049-0218 100 µM -0.491051481670183 0.306077679398277 no 2345 0.311695018086249 758 295161
SGTC_2062 5245942 200 µM -0.491335005427101 0.305975831444909 no 2346 0.311594762580857 747 1376160
SGTC_301 4119-0100 24.5 µM -0.491838868677646 0.305794869729214 no 2347 0.311416628326599 766 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_550 4123-0385 25.7 µM -0.492086135254327 0.305706081654929 no 2348 0.311329226609784 773 5731123
SGTC_2040 5100729 123 µM -0.492668455110987 0.305497028329494 no 2349 0.311123435086317 758 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1159 4092-0538 61.2 µM -0.492760234392406 0.305464085271275 no 2350 0.311091005721518 752 717301
SGTC_707 0865-0008 204 µM -0.492967859748633 0.305389566483993 no 2351 0.311017648623824 770 723043
SGTC_2603 homopterocarpin 100 µM -0.495721951823963 0.304401859503579 no 2352 0.310045298550767 751 101795 A weak amylase inhibitor.
SGTC_1125 tnp00248 1.32998 µM -0.49719719487868 0.303873374908023 no 2353 0.309524999688017 739 24207736
SGTC_3214 9129694 49.47 µM -0.498509643964148 0.303403553203722 no 2354 0.309062436763417 780 17158655
SGTC_999 SEC7.066 22.7 µM -0.499124855535335 0.303183435683726 no 2355 0.308845714128154 745 740511 YDR170C SEC7
SGTC_2645 abamectin 100 µM -0.500041141477483 0.302855728745743 no 2356 0.308523054387255 761 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3069 9117009 49.47 µM -0.500534994170958 0.302679169599049 no 2357 0.308349211027034 748 41904981
SGTC_3337 9144342 33.5465 µM -0.50203367527266 0.302143652983697 no 2358 0.307821916567426 719 17682949
SGTC_2719 novobiocin 32.65 µM -0.502350761391455 0.302030404640273 no 2359 0.307710404104844 767 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1626 st003712 1.76 µM -0.502388330734774 0.302016987889767 no 2360 0.307697192940352 789 24207035
SGTC_2139 5578692 56.4705 µM -0.503077780590936 0.301770819347762 no 2361 0.307454793933019 769 650991 YMR113W FOL3
SGTC_3088 9117578 49.47 µM -0.503538813098419 0.301606257716475 no 2362 0.307292749529251 780 678341
SGTC_497 capsazepine 133 µM -0.50379907628956 0.301513376813517 no 2363 0.307201288437563 738 2733484 A calcium channel blocker.
SGTC_2520 obtusaquinone 4.71 µM -0.503804660723342 0.301511384020987 no 2364 0.30719932610009 769 5967872
SGTC_1667 st014849 34.6 µM -0.505960104549414 0.300742661827598 no 2365 0.306442328452782 768 5348460
SGTC_2626 ethyl orsellinate 100 µM -0.506322498093795 0.300613503895295 no 2366 0.306315135822046 765 75653 A natural product.
SGTC_1123 mangostin 811.285 nM -0.506750564918932 0.300460972115789 no 2367 0.30616492329337 738 5281650 An antioxidant.
SGTC_2727 riluzole 51.77 µM -0.506778143766508 0.300451146225827 no 2368 0.306155246742739 764 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3079 9117512 49.47 µM -0.507142541366129 0.300321330984141 no 2369 0.306027403781373 795 7185044
SGTC_429 1112-0049 25.5 µM -0.507602007684896 0.300157684018805 no 2370 0.305866241182353 737 2836170
SGTC_1076 itraconazole 331 nM -0.508906476901204 0.299693294405267 no 2371 0.30540888991507 739 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1272 0839-0021 27 µM -0.509722696628236 0.299402886708233 no 2372 0.305122874884428 759 5027250
SGTC_2461 5755302 26.15 µM -0.510034930164993 0.299291829025005 no 2373 0.305013495253392 798 2788904
SGTC_158 k038-0087 26.446 µM -0.510360491751776 0.299176050621305 no 2374 0.304899465174691 716 X158
SGTC_2720 fluspirilene 36.88 µM -0.51050035013414 0.299126319483943 no 2375 0.304850484676882 770 3396 An atypical antipsychotic.
SGTC_3027 9089541 49.47 µM -0.51150405708381 0.298769529407296 no 2376 0.304499074131622 762 9943819
SGTC_1317 1273-0028 910 nM -0.513517240351178 0.298054482108792 no 2377 0.303794777074595 761 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1874 staurosporine 7.6 µM -0.513649966908386 0.298007367382414 no 2378 0.303748369232376 791 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_34 0469-0683 81.75 µM -0.51384697904334 0.297937439085778 no 2379 0.303679489770717 746 3690923
SGTC_1510 1123-0200 71.5 µM -0.515665033651043 0.297292484648331 no 2380 0.303044190103751 802 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_674 0498-0004 451 µM -0.515732186632205 0.297268674366016 no 2381 0.303020735606523 757 4231473
SGTC_1498 4478-3555 97.6 µM -0.516075604604868 0.297146923049497 no 2382 0.302900802836865 765 3437919
SGTC_411 enrofloxacin 100 µM -0.517811523292255 0.296531840287822 no 2383 0.302294888810272 767 71188 A bacterial gyrase inhibitor.
SGTC_509 pifithrin 175 µM -0.517988580981051 0.296469136776659 no 2384 0.302233118252549 778 4817 A p53 inhibitor.
SGTC_3155 9099265 49.47 µM -0.518502417094107 0.296287200396162 no 2385 0.302053887046096 787 25236499
SGTC_195 4234-0266 16.654 µM -0.518965821237918 0.296123164625072 no 2386 0.301892287963153 757 2303354
SGTC_138 0850-0259 40.9225 µM -0.521504618631926 0.295225221732166 no 2387 0.301007644488932 761 6813004
SGTC_335 4077-0256 27.6 µM -0.522453654886002 0.294889880869722 no 2388 0.300677253314288 780 3121989
SGTC_1179 1021-1431 9.29 µM -0.522487381872825 0.294877966708847 no 2389 0.300665514837525 791 2840958
SGTC_3229 9132204 49.47 µM -0.522820278514568 0.294760381859436 no 2390 0.30054966324387 772 17682924
SGTC_315 k915-0449 187 µM -0.523351451180418 0.294572807273249 no 2391 0.300364851226393 762 20970215 YNL149C PGA2
SGTC_982 1491-0518 27.5 µM -0.52351277785085 0.294515848411134 no 2392 0.300308730668572 763 3091256
SGTC_2187 6125751 200 µM -0.52424962598948 0.294255757489958 no 2393 0.300052464273018 764 874498
SGTC_2664 lyso-paf C-16 73.48 µM -0.52468281444258 0.294102901187922 no 2394 0.299901853038205 781 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1769 st044406 64.4 µM -0.526054710016965 0.293619051916316 no 2395 0.299425097464584 788 670903
SGTC_660 4031-1742 102 µM -0.526081337513906 0.293609664400072 no 2396 0.299415847385645 760 6738706
SGTC_821 1114-0266 29.2 µM -0.526314900431431 0.293527327817459 no 2397 0.299334715931505 762 3123235
SGTC_2529 gangaleoidin 93.61 µM -0.526673626424913 0.293400889048232 no 2398 0.299210126696533 786 4565183
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.527414407489664 0.293139868688805 no 2399 0.298952920296681 776 5282362
SGTC_1646 st011709 75.6 µM -0.529830207130864 0.292289390745746 no 2400 0.298114829750204 778 5757843
SGTC_457 grayanotoxin iii 135 µM -0.532086549317314 0.291496087585645 no 2401 0.297333026434651 783 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_897 1000-0139 31.4 µM -0.532900186959121 0.291210268792216 no 2402 0.297051337902987 771 6151020
SGTC_1146 3579-1023 7 µM -0.534359695990204 0.290697893113938 no 2403 0.296546349065947 796 X1146
SGTC_1671 st016596 74.5 µM -0.535322804878914 0.290360014901188 no 2404 0.29621332980286 768 2829167
SGTC_3026 9090633 49.47 µM -0.5359876039026 0.290126897190294 no 2405 0.295983558844479 769 25236842
SGTC_789 1309-1135 70.6 µM -0.536229873818609 0.290041964892868 no 2406 0.295899844726645 752 3092424
SGTC_2107 5363541 170.161 µM -0.537049200835532 0.28975482071505 no 2407 0.29561681448791 758 244052
SGTC_190 3970-0790 3.722 µM -0.537473806087229 0.289606064585428 no 2408 0.295470186832405 768 2832352
SGTC_2411 st077133 39.94 µM -0.538539428724085 0.289232892521374 no 2409 0.295102345966203 800 1403142 YNL221C POP1
SGTC_654 1124-0271 80.9 µM -0.538665430240902 0.289188782799991 no 2410 0.295058865615724 774 5403748
SGTC_276 colchicine 750 µM -0.538739402920414 0.289162888440075 no 2411 0.295033340646736 800 2833 A microtubule depolymerizer.
SGTC_1945 st075991 56.6 µM -0.539397742433079 0.288932482743997 no 2412 0.294806219226381 758 1084980
SGTC_1842 st055362 61.2 µM -0.540474886467409 0.288555690232644 no 2413 0.294434787813296 737 676032
SGTC_1974 st069448 26.9 µM -0.540766044620597 0.288453880837351 no 2414 0.294334424892757 768 6323587 YNR016C ACC1
SGTC_2770 toltrazuril 17.5 µM -0.541158737488006 0.288316594577262 no 2415 0.294199087738163 770 68591 Kills coccidiodes.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.542504113769135 0.287846481926192 no 2416 0.293735637145814 792 61125 An anti-inflammatory.
SGTC_1554 st069299 38.7 µM -0.543909848169154 0.287355665541887 no 2417 0.293251755837198 755 24207999
SGTC_2646 retinol 96.75 µM -0.544427715860602 0.287174950332965 no 2418 0.293073588818974 784 445354 A vitamin A analog and teratogen.
SGTC_510 ag-490 170 µM -0.545979509560862 0.286633758490218 no 2419 0.292540011134276 774 5328779
SGTC_1949 st076024 69.1 µM -0.547110356971809 0.286239677612453 no 2420 0.292151458632946 789 2921930
SGTC_2109 5483026 200 µM -0.54771964383303 0.286027458329867 no 2421 0.291942210861749 806 759335
SGTC_3295 9122362 53.5725 µM -0.549626680996948 0.285363706382944 no 2422 0.291287727387978 791 4730473
SGTC_2507 purpurin 79.67 µM -0.549716820398225 0.285332351167991 no 2423 0.291256809054485 785 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1938 st074717 56.4 µM -0.550541705390755 0.28504548912342 no 2424 0.290973939934335 769 17250979
SGTC_505 gw-5074 63.9 µM -0.55226463414174 0.284446767280544 no 2425 0.290383528561016 772 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3160 9100216 49.47 µM -0.554977116852032 0.283505392402797 no 2426 0.289455156257894 763 17191039
SGTC_619 1652-1634 108 µM -0.555706582816325 0.2832524841495 no 2427 0.289205727863637 788 5400454
SGTC_1059 3448-6867 171 µM -0.555815308963118 0.28321479770485 no 2428 0.289168559474039 788 3934407
SGTC_3172 9105863 49.47 µM -0.556146378075827 0.28310005799098 no 2429 0.289055396246519 774 2348785
SGTC_570 0987-0065 62.6 µM -0.556199036823686 0.283081809931599 no 2430 0.289037398801536 769 3104428
SGTC_2659 sanguinarine 24.21 µM -0.556268268603382 0.283057819608138 no 2431 0.289013737910217 803 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2430 5571206 200 µM -0.556277736620097 0.283054538809447 no 2432 0.289010502159063 790 1731771
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.556491310341405 0.282980537411963 no 2433 0.288937516595043 759 6708739 YPR165W RHO1
SGTC_262 fenpropimorph 62.5 µM -0.55785390170582 0.282508630394113 no 2434 0.288472076063049 798 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1087 pterostilbene 9.05 µM -0.55916408286083 0.282055231779632 no 2435 0.288024871572506 794 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1572 epiandrosterone 68.9 µM -0.560382687024915 0.281633838884245 no 2436 0.287609219037865 784 441302 A steroid.
SGTC_109 0132-0036 33.701 µM -0.564228917090133 0.280305808725061 no 2437 0.286299175197592 731 67274 A color developer.
SGTC_1647 st011722 22.4 µM -0.568422744580066 0.278861225136311 no 2438 0.284873974998126 784 2854783
SGTC_2093 5331342 194.4 µM -0.56879266504588 0.278733978361118 no 2439 0.284748426499491 779 33839
SGTC_2097 5376186 200 µM -0.568796743083795 0.278732575738264 no 2440 0.284747042588242 758 742755
SGTC_2589 lobaric acid 100 µM -0.568894870265948 0.278698826370067 no 2441 0.284713743397156 783 73157 A novel microtubule depolymerizer.
SGTC_3274 9138298 49.47 µM -0.569604816975942 0.278454710162816 no 2442 0.284472880309453 790 17015756
SGTC_2395 5646831 180.19 µM -0.571514024787272 0.277798743562998 no 2443 0.283825628111461 808 6808628
SGTC_2858 9025781 8.96 µM -0.574914597341969 0.276632245195748 no 2444 0.282674528538491 787 4894980 YPL153C RAD53
SGTC_157 1348-1695 65.819 µM -0.575300056094111 0.276500172916514 no 2445 0.282544191795377 758 5380510
SGTC_836 0330-0104 1.35 µM -0.576183378344039 0.276197631029774 no 2446 0.28224561945029 765 46494820
SGTC_1827 berberine 7.24 µM -0.577464529189706 0.275759119943488 no 2447 0.281812846798943 779 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_349 k015-0014 24 µM -0.578156948880109 0.275522261716116 no 2448 0.281579080688093 775 2196908
SGTC_844 0330-0132 15.3 µM -0.578403170237948 0.275438060109028 no 2449 0.28149597704744 783 2828079
SGTC_611 3453-1652 23.7 µM -0.578681875076282 0.275342765233591 no 2450 0.281401923992803 803 1560575
SGTC_1675 st018485 24.5 µM -0.579733491476119 0.274983342288815 no 2451 0.281047177172124 802 3323024
SGTC_3109 9122853 49.47 µM -0.579941271406211 0.274912354327028 no 2452 0.280977111339767 811 1234709
SGTC_908 3448-7491 47.7 µM -0.58031755681766 0.27478381949969 no 2453 0.280850244970403 759 1203031
SGTC_137 0438-0332 85.389 µM -0.582267895933367 0.274118080912206 no 2454 0.280193123237766 815 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1879 gemcitabine 100 µM -0.584583321357691 0.273328757864098 no 2455 0.279413962535764 786 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2033 5192550 145 µM -0.585459446613438 0.273030382659651 no 2456 0.279119413497569 772 182073
SGTC_3115 9123671 49.47 µM -0.58607123906274 0.272822125019774 no 2457 0.278913821414168 802 3286988
SGTC_1331 1472-0049 76.2 µM -0.586325100735852 0.272735732195983 no 2458 0.278828533151667 797 24051409
SGTC_2842 9000675 19.48 µM -0.586570830160308 0.272652119825711 no 2459 0.278745989118438 787 2989072
SGTC_1276 0871-0068 94.2 µM -0.586721217881271 0.272600954884429 no 2460 0.278695477597226 794 3414906
SGTC_2332 7982454 138.89 µM -0.587167971158794 0.272448988507371 no 2461 0.27854545049291 807 2981748
SGTC_3221 9128209 49.47 µM -0.587700975112977 0.272267738392297 no 2462 0.278366510471853 804 16460723
SGTC_2639 lactacystin 53 µM -0.588528160997293 0.271986569240387 no 2463 0.278088918720301 779 3870 A proteasome inhibitor.
SGTC_620 0109-0052 432 µM -0.588803610757875 0.27189297304031 no 2464 0.277996511699648 808 493037
SGTC_880 0833-0487 87.2 µM -0.588810334998071 0.271890688383616 no 2465 0.277994256060027 798 76075
SGTC_2381 9035592 200 µM -0.589429008437659 0.271680526113706 no 2466 0.27778676089573 795 4749657
SGTC_1153 4055-0057 267 µM -0.590250932513082 0.271401445105615 no 2467 0.277511215090161 803 882706
SGTC_1959 st077091 55.8 µM -0.590893388216907 0.271183401365336 no 2468 0.277295928183479 815 821356 YKL052C ASK1
SGTC_186 3455-3465 67.277 µM -0.591217966630902 0.271073275563177 no 2469 0.277187193022534 800 755278
SGTC_3074 9116018 49.47 µM -0.593187911487713 0.270405374319852 no 2470 0.276527700897571 846 17027303
SGTC_339 3091-4833 71.4 µM -0.593431405946477 0.270322875731616 no 2471 0.27644623801603 792 3240077
SGTC_923 1900-2434 73.3 µM -0.595331218805481 0.269679630729437 no 2472 0.275811045922699 826 5910570
SGTC_118 0083-0097 135.343 µM -0.596255887082162 0.269366831079284 no 2473 0.275502147801294 814 5207356
SGTC_3084 9116877 49.47 µM -0.59695812293831 0.269129398154225 no 2474 0.27526767002346 801 27241325
SGTC_215 1287-0124 461.5 µM -0.597519579492726 0.268939639682965 no 2475 0.275080269393255 793 5560863
SGTC_103 0844-0104 51.839 µM -0.597583972668948 0.268917880671681 no 2476 0.275058780524423 800 5375804
SGTC_1230 0170-0365 3.77 µM -0.597624743038654 0.268904104468066 no 2477 0.275045175331297 795 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1401 3807-4679 7.6 µM -0.598406090554791 0.268640157629175 no 2478 0.274784501419787 810 3291456
SGTC_2292 7671323 168.05 µM -0.598639178732975 0.268561443380603 no 2479 0.274706761909785 803 937504
SGTC_270 tamoxifen 5.46 µM -0.598803925571511 0.268505815104536 no 2480 0.274651822128411 810 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2551 apiole 73.87 µM -0.598996696985805 0.268440731429506 no 2481 0.274587543591498 787 10659 A possible DNA adduct former.
SGTC_299 1273-0059 1.44 µM -0.599629863155368 0.268227017072796 no 2482 0.274376470146998 793 2848077
SGTC_2088 5278280 127.392 µM -0.599735799495776 0.268191268443705 no 2483 0.274341162835436 798 791502
SGTC_3241 9133421 49.47 µM -0.601993893710131 0.267429836452255 no 2484 0.273589101023246 821 17018221
SGTC_1172 0370-0043 85 µM -0.602271950685827 0.267336150771194 no 2485 0.273496564308866 794 376585
SGTC_2686 alizarin 95.37 µM -0.602775514761295 0.267166527185406 no 2486 0.273329018801523 769 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2023 5144124 124 µM -0.603158924116819 0.267037413685091 no 2487 0.273201485188575 797 2830192
SGTC_1168 k815-0004 80.5 µM -0.603575794544468 0.266897067896109 no 2488 0.27306285486807 801 642433
SGTC_236 1509-0011 5.31 µM -0.604146619658547 0.26670495137893 no 2489 0.27287308347334 827 3107280
SGTC_2877 9040724 71.43 µM -0.604341611677923 0.26663934101706 no 2490 0.27280827316814 794 6463895
SGTC_2733 amorolfine 100 µM -0.605546369957296 0.266234148414132 no 2491 0.272408012085732 821 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3013 9080133 71.4286 µM -0.606422003149305 0.265939845149486 no 2492 0.27211728054467 798 17050193
SGTC_3025 9087895 49.47 µM -0.608354581399534 0.265290882965571 no 2493 0.271476163927047 799 17173641
SGTC_888 0916-0002 6.97 µM -0.609072613117131 0.265049972018256 no 2494 0.271238154787467 782 2802138 YIL048W NEO1
SGTC_2336 9001819 198.65 µM -0.60929638896807 0.264974914418772 no 2495 0.271164000085901 809 2989602
SGTC_1372 2752-0194 270 µM -0.609397601427479 0.264940969869515 no 2496 0.27113046368469 792 823334
SGTC_36 0335-0881 14.2 µM -0.611122193542406 0.264362917445322 no 2497 0.270559344073635 792 23828853
SGTC_2244 6635614 200 µM -0.611577205234609 0.264210512778359 no 2498 0.270408761687635 816 836499
SGTC_554 4483-2211 187 µM -0.611813709014158 0.264131314294257 no 2499 0.270330509249423 792 747107
SGTC_857 0438-0306 1.35 µM -0.61254285207155 0.263887220870016 no 2500 0.270089327624518 793 4686136
SGTC_2012 4023501 200 µM -0.61286562580847 0.263779203433637 no 2501 0.269982596822566 833 3477460
SGTC_9 0092-0002 10.449 µM -0.613784800923482 0.263471721628077 no 2502 0.269678771120082 801 759368
SGTC_2970 9090938 41.86 µM -0.615635397000628 0.262853216980057 no 2503 0.269067591926612 784 17217104
SGTC_1371 2421-0008 32.7 µM -0.6167950185064 0.262466028006802 no 2504 0.268684969074521 808 2827552
SGTC_2193 5925765 200 µM -0.616799778149021 0.262464439399516 no 2505 0.268683399170417 799 877370
SGTC_165 k038-0023 64.381 µM -0.618664109191318 0.261842567736006 no 2506 0.268068829329512 800 46368543
SGTC_1102 cgs 12066b 26.1 µM -0.619792414656207 0.261466574317481 no 2507 0.267697231631726 790 6438352 A 5-HT1B full agonist.
SGTC_1300 1094-0077 113 µM -0.620302956886932 0.26129653377053 no 2508 0.267529174288109 808 5532636
SGTC_523 1934-0222 13.7 µM -0.621938889800292 0.260752054950919 no 2509 0.266991025915631 830 1361595
SGTC_1310 1188-0297 994 nM -0.622322770969795 0.260624374449561 no 2510 0.266864825514548 803 1588352
SGTC_2750 bromebric acid 70.15 µM -0.622934063760306 0.260421122326629 no 2511 0.266663926085978 805 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3254 9136651 49.47 µM -0.624627465890307 0.259858500317354 no 2512 0.266107794433333 833 16454030
SGTC_1432 4049-0298 68.4 µM -0.626575905704574 0.25921192039625 no 2513 0.265468633118148 815 741646
SGTC_2404 5161160 200 µM -0.627008765984757 0.259068390867877 no 2514 0.265326744532249 824 2831543
SGTC_1459 k035-0031 35.7 µM -0.627012399500653 0.259067186226219 no 2515 0.265325553653979 804 3877128 YMR208W ERG12
SGTC_1578 josamycin 24.2 µM -0.627774292862581 0.258814655073284 no 2516 0.265075904425225 806 5282165 A P450 substrate.
SGTC_399 oxolinic acid 75 µM -0.627832747008712 0.25879528558665 no 2517 0.265056755713186 789 4628 A DNA gyrase inhibitor.
SGTC_2196 6573537 42.6665 µM -0.629958241310842 0.258091487309941 no 2518 0.264360952939668 826 2903087
SGTC_2081 5214970 32.255 µM -0.630040523856551 0.258064261703993 no 2519 0.264334035595068 793 2063512
SGTC_725 1497-0963 19 µM -0.630619203992553 0.257872830401168 no 2520 0.264144769587593 809 3549977
SGTC_3290 9121031 71.43 µM -0.631273139724254 0.257656592752602 no 2521 0.263930973222452 803 17014854
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.631721435451942 0.257508408721967 no 2522 0.263784459342051 801 688667
SGTC_2372 9071633 200 µM -0.634548747570507 0.25657486248768 no 2523 0.262861382020424 808 21321366
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.634698735709753 0.256525387396339 no 2524 0.26281245919629 814 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1220 1838-0075 193 µM -0.634698948275962 0.256525317282771 no 2525 0.262812389865184 794 5529645
SGTC_3330 9141424 71.43 µM -0.636696646030005 0.255866830944497 no 2526 0.262161229338506 791 27261020
SGTC_2065 5221596 34.26 µM -0.636772272000868 0.255841920256392 no 2527 0.26213659488936 796 788581
SGTC_2375 9072683 200 µM -0.636923152053748 0.255792225160082 no 2528 0.26208745067472 826 16798029
SGTC_784 4579-0127 173 µM -0.639406338461634 0.254975066907308 no 2529 0.261279313310088 822 1948547
SGTC_1265 0819-1001 68.8 µM -0.640914517814804 0.25447942810012 no 2530 0.260789111482203 816 3106768
SGTC_2954 9074818 52.69 µM -0.642316997620963 0.254018979145757 no 2531 0.260333690026208 822 16648742
SGTC_692 k241-0027 77.8 µM -0.642813316712435 0.253856137115501 no 2532 0.260172620595344 810 3600480
SGTC_2497 7-hydroxyflavone 100 µM -0.643346764639277 0.253681174251244 no 2533 0.259999559107954 833 5281894
SGTC_2654 protoveratrine a 100 µM -0.644032790896683 0.253456261122503 no 2534 0.25977708536323 838 5702278 A heart drug and vasodilator.
SGTC_2365 9042475 200 µM -0.64416787881349 0.253411985015131 no 2535 0.259733288830722 807 6464479
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.646707176739607 0.252580467482689 no 2536 0.258910738705185 818 390807
SGTC_182 3448-4371 550.524 µM -0.647368653315517 0.252364096836795 no 2537 0.258696689269372 775 3491403
SGTC_1062 mesoridazine 14.2 µM -0.647735750343757 0.252244060649235 no 2538 0.258577938641324 808 4078 A neuroleptic.
SGTC_1139 k015-0024 46.9 µM -0.650319509740131 0.251400055672289 no 2539 0.257742928707782 819 2766652
SGTC_839 0122-0028 230 µM -0.650874425325766 0.251218983119567 no 2540 0.257563775874899 833 759448
SGTC_1324 1418-0026 34.4 µM -0.652294322642558 0.250755975619713 no 2541 0.2571056609153 817 1372513
SGTC_823 0417-1665 178 µM -0.652335632860646 0.25074251173662 no 2542 0.257092338953556 832 3429856
SGTC_2386 9075165 157.42 µM -0.652719331129177 0.250617474561912 no 2543 0.256968618836918 811 16452277
SGTC_2913 7966556 36.57 µM -0.653803923819499 0.250264213038892 no 2544 0.256619069101302 808 2976516
SGTC_2380 9035439 200 µM -0.654365691205929 0.250081344233262 no 2545 0.256438116368463 821 6462575
SGTC_1466 k213-0079 57.5 µM -0.655389453801122 0.249748267261272 no 2546 0.256108519906891 841 3657981
SGTC_1563 conessine 56.1 µM -0.656214114166772 0.249480138781486 no 2547 0.255843184401237 822 441082 An anti-amoebic, histamine inhibitor.
SGTC_1161 k007-0610 110 µM -0.656248189417191 0.249469062912239 no 2548 0.255832223734305 827 5843850
SGTC_4 0960-0234 25.671 µM -0.658389561925566 0.24877355256154 no 2549 0.255143920445455 803 6821112
SGTC_1793 st048256 72.231 µM -0.658571852542786 0.248714392924923 no 2550 0.255085371372497 821 672022
SGTC_942 3253-1115 227 µM -0.661575171812617 0.247740790972715 no 2551 0.254121761888193 853 46497897
SGTC_2317 5986382 200 µM -0.663145543850312 0.247232526540185 no 2552 0.253618672117739 850 877883
SGTC_1367 1812-0510 76.9 µM -0.663529389117082 0.247108376568962 no 2553 0.25349578174414 804 1142582 YDR527W RBA50
SGTC_861 0443-0273 110 µM -0.664043209381949 0.246942240013808 no 2554 0.253331328078916 823 6149169
SGTC_2224 6650123 117.647 µM -0.664568076330025 0.246772593403879 no 2555 0.253163396728896 823 2908370
SGTC_2316 5844804 197.44 µM -0.665192376356719 0.246570889478325 no 2556 0.252963727994586 814 776813
SGTC_946 3434-1334 87.4 µM -0.665208175917491 0.246565785973926 no 2557 0.252958675925378 812 4047976
SGTC_1198 1612-1005 86.7 µM -0.665558357151419 0.246452686504388 no 2558 0.252846715568752 830 6998509
SGTC_396 dithiazanine 1.25 µM -0.665626347906602 0.246430730474514 no 2559 0.252824980508869 809 10578 An antihelmenthic.
SGTC_1644 st010134 20.9 µM -0.666464367132419 0.246160197797946 no 2560 0.252557166087225 833 3818134
SGTC_1244 0416-0015 52.5 µM -0.666614718151373 0.246111677744958 no 2561 0.252509132683878 814 96201
SGTC_715 0868-0130 184 µM -0.667574837999058 0.245801956713919 no 2562 0.252202511872519 833 2876258
SGTC_310 1273-0058 1.06 µM -0.667720354382223 0.245755033460571 no 2563 0.252156057365533 798 2734232
SGTC_363 0455-0021 3.06 µM -0.668725344908818 0.245431095278758 no 2564 0.251835348436292 821 4597466
SGTC_699 0375-0592 111 µM -0.668893496905615 0.245376917330931 no 2565 0.251781709417885 791 762578
SGTC_2374 9071832 200 µM -0.669098593484686 0.245310844678078 no 2566 0.251716293567011 816 17381698
SGTC_871 0574-0004 149 µM -0.669150831766355 0.245294017442702 no 2567 0.251699633525679 835 9551173
SGTC_1677 st019204 53.9 µM -0.670122472740034 0.244981141122679 no 2568 0.251389860086273 812 3945625
SGTC_2329 6138490 200 µM -0.670244320928616 0.244941920168788 no 2569 0.251351027315886 830 720019
SGTC_433 pimozide 108 µM -0.670934010369291 0.244719984033657 no 2570 0.251131284476307 821 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3215 9129942 49.47 µM -0.674236486618345 0.243658777605694 no 2571 0.2500804881053 837 17682944
SGTC_2356 9061756 188.97 µM -0.674385754255231 0.243610871216141 no 2572 0.250033048632668 813 20104043
SGTC_3317 9138495 8.753 µM -0.67445229431601 0.243589517294709 no 2573 0.250011902751546 828 17020139
SGTC_3103 9120822 49.47 µM -0.675286363710656 0.243321934955593 no 2574 0.249746922910572 839 17141819
SGTC_177 1327-0068 8.361 µM -0.678703871686434 0.242227206505072 no 2575 0.248662756255635 828 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2653 dihydrofissinolide 100 µM -0.681134974718551 0.241450080632189 no 2576 0.24789304420909 832 6857746
SGTC_2928 9011484 9.79 µM -0.681248577184095 0.24141379964182 no 2577 0.24785710763483 824 2994751
SGTC_2205 7238770 200 µM -0.683062760322513 0.240834809104759 no 2578 0.247283592802431 823 279867
SGTC_1777 st045864 34.765 µM -0.684277907248743 0.240447421880601 no 2579 0.246899847465779 853 4691462
SGTC_1760 st045453 10.4495 µM -0.68511733896197 0.240180010489152 no 2580 0.246634939844922 841 3323419 YIL048W NEO1
SGTC_1206 3978-0017 132 µM -0.685119486672808 0.240179326517153 no 2581 0.246634262266245 823 3873677
SGTC_2190 6049624 200 µM -0.688858398753348 0.238990222702968 no 2582 0.245456190580597 829 2265554
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.690193246225767 0.238566475882061 no 2583 0.245036334994573 811 279621
SGTC_1455 4262-0120 131 µM -0.690813154106986 0.23836982628921 no 2584 0.244841484024172 837 1529587
SGTC_172 1112-0046 2.638 µM -0.691652100790812 0.238103833776472 no 2585 0.244577917095096 835 2802135 YIL048W NEO1
SGTC_1225 1216-0074 20.6 µM -0.694003478363415 0.2373591845975 no 2586 0.243840013777173 835 4241466
SGTC_901 1112-0062 60.1 µM -0.69411535931296 0.237323785326166 no 2587 0.243804933552097 834 1908457
SGTC_2706 st078239 82.5 µM -0.695240344738652 0.236967999728896 no 2588 0.243452346291265 840 15434492
SGTC_1089 terbinafine 2.25 µM -0.696463376829681 0.236581538944865 no 2589 0.243069342494057 846 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2325 6158266 200 µM -0.696864472753295 0.236454873879078 no 2590 0.242943806595619 826 3623240
SGTC_1984 st072354 53.1 µM -0.697759536098889 0.236172349799578 no 2591 0.242663794184711 831 5762938
SGTC_1754 st042065 16.137 µM -0.697832098891868 0.236149453720852 no 2592 0.242641101235648 831 1126236 YIL048W NEO1
SGTC_179 1273-0063 6.77 µM -0.703593149810354 0.234335549649639 no 2593 0.240843089287765 848 3108139
SGTC_2580 diallyl disulphide 81.36 µM -0.706208454342503 0.233514655966304 no 2594 0.240029256781448 831 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1661 st013063 9.66 µM -0.706305724438037 0.233484155551666 no 2595 0.239999017145047 857 721395
SGTC_734 2023-0417 80 µM -0.706742176842158 0.233347326930685 no 2596 0.239863357010688 848 3935732
SGTC_2326 6164455 177.58 µM -0.707641580977116 0.23306550246476 no 2597 0.239583932059681 840 2888790
SGTC_1090 efavirenz 20.7 µM -0.709135627520219 0.232597767345527 no 2598 0.23912015788943 832 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2865 9030313 51.95 µM -0.709294654764073 0.232548012076202 no 2599 0.239070822387578 842 42562754
SGTC_438 sphingosine 6.67 µM -0.709419131016271 0.232509070995106 no 2600 0.239032209626564 819 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2606 farnesol 9.78 µM -0.71008169429406 0.232301856098515 no 2601 0.238826738668527 859 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_181 1447-1644 8.07 µM -0.710830574382247 0.232067769595484 no 2602 0.238594615908299 855 534600
SGTC_2712 st079126 47.7 µM -0.7116875236732 0.231800063779265 no 2603 0.238329147596484 835 3152970
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.711972727039623 0.231711006129155 no 2604 0.23824083233816 861 229346 A bile salt which induces apoptosis.
SGTC_69 0096-0274 206.684 µM -0.712540569859688 0.231533748218113 no 2605 0.238065049150256 864 6741392
SGTC_1116 jasmonic acid 1.58368 µM -0.71289635691317 0.231422724201761 no 2606 0.237954946837697 858 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2663 amphotericin b 100 µM -0.717839931601204 0.229883148038288 no 2607 0.236427994413628 833 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2624 nerol 100 µM -0.718886978139627 0.229557803976615 no 2608 0.236105280221559 860 637566 A natural product oil.
SGTC_2775 cyproheptadine 69.59 µM -0.720435798553088 0.229077019361585 no 2609 0.235628357695618 836 2913 A selective serotonin reuptake inhibitor.
SGTC_222 nsc-310342 10.666 µM -0.72084104485113 0.228951316158321 no 2610 0.235503659470214 851 432556
SGTC_3012 9080433 71.4286 µM -0.721063859586417 0.228882217830507 no 2611 0.235435112727406 852 17688859
SGTC_1508 1080-0625 72.9 µM -0.721619566126915 0.228709935562971 no 2612 0.235264203107652 827 767111
SGTC_2076 5212012 200 µM -0.721914481783393 0.228618534265464 no 2613 0.235173528527778 832 604802
SGTC_1256 0570-0116 285 µM -0.722374104827954 0.228476127182247 no 2614 0.235032251604719 842 410638
SGTC_462 ag-879 158 µM -0.722411671772121 0.228464489849827 no 2615 0.23502070651466 866 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2925 9010536 32.5 µM -0.72338183674353 0.228164071536251 no 2616 0.234722663529958 811 2994177
SGTC_2367 9070478 135.38 µM -0.723532827428139 0.228117336205252 no 2617 0.234676296698968 837 572802
SGTC_2968 9090663 33.37 µM -0.723584853557555 0.228101234085479 no 2618 0.234660321477716 863 25236811
SGTC_2143 5623677 140.463 µM -0.723701824103996 0.228065033961837 no 2619 0.234624406522489 827 5375313
SGTC_112 phenothiazine 287.218 µM -0.724248389697231 0.227895925300847 no 2620 0.234456627829426 851 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_67 0335-0847 266 µM -0.725685074827226 0.227451748213918 no 2621 0.234015926763568 866 4552207 YOR254C SEC63
SGTC_1688 st021091 57.6 µM -0.726728610379788 0.227129426361441 no 2622 0.233696111651938 863 3656366
SGTC_1207 2099-0101 141 µM -0.729349156487488 0.226321141903324 no 2623 0.232894055165371 840 5837381
SGTC_3331 9141060 1.957 µM -0.730731705095532 0.225895362494786 no 2624 0.232471522902119 843 4906567 YPR165W RHO1
SGTC_902 1120-0002 2.07 µM -0.731437835051135 0.225678072607768 no 2625 0.232255881192158 833 3280475
SGTC_700 3453-2283 142 µM -0.731948415340176 0.225521030840358 no 2626 0.232100026837439 855 565664
SGTC_1969 st069479 40.1 µM -0.732075857726059 0.225481842387874 no 2627 0.232061134199777 857 3895485
SGTC_2563 tomatine 8.54 µM -0.732560677255036 0.225332795920833 no 2628 0.231913211009225 875 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2829 7992743 58.44 µM -0.734974136490749 0.224591664775746 no 2629 0.231177622835232 846 16462845
SGTC_1895 st058434 18.3 µM -0.736435920332889 0.224143449782653 no 2630 0.230732725628167 877 5393175
SGTC_1255 0566-0045 221 µM -0.739231513022748 0.223287676122478 no 2631 0.229883214162121 844 2788469
SGTC_2383 9036125 200 µM -0.740743250905579 0.222825685803538 no 2632 0.22942456482587 847 79580
SGTC_345 1362-0200 395 µM -0.740807596134426 0.222806033856374 no 2633 0.229405054377417 855 1419823
SGTC_2379 9035213 200 µM -0.742633218533613 0.222248874497988 no 2634 0.228851885647971 833 646551
SGTC_944 3370-0224 231 µM -0.74280203835518 0.222197392780338 no 2635 0.228800770610459 849 4580514
SGTC_1360 1598-0022 39.8 µM -0.743490213869572 0.221987603622869 no 2636 0.228592472080876 854 761525
SGTC_854 0422-0053 192 µM -0.743516496748691 0.221979593573761 no 2637 0.228584518831353 864 3596728
SGTC_555 4296-0685 37 µM -0.74363004085723 0.221944991427021 no 2638 0.228550161952841 862 2908540 YHR072W ERG7
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.744009890635447 0.221829256002744 no 2639 0.228435245743603 849 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.744317036651541 0.221735697707073 no 2640 0.228342348396243 849 1241132 A phosphatase inhibitor.
SGTC_1458 k015-0034 6.33 µM -0.744342478995464 0.221727948846157 no 2641 0.228334654225913 846 3598957
SGTC_2011 4012611 177 µM -0.744799319406937 0.221588837337181 no 2642 0.228196523203593 847 2049887
SGTC_201 4262-0159 12.803 µM -0.745897890859544 0.221254517941869 no 2643 0.227864549716298 854 1341029
SGTC_934 2950-0684 338 µM -0.745955178321118 0.221237092028892 no 2644 0.227847245675467 847 1121253
SGTC_209 4077-0173 175.592 µM -0.745963935989682 0.221234428157903 no 2645 0.227844600431335 833 15993494
SGTC_1098 clofazimine 15.1 µM -0.746444675001776 0.221088227125646 no 2646 0.227699420256197 863 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_309 k408-0051 1.48 µM -0.746917141201575 0.220944595880506 no 2647 0.227556789169575 847 3640463
SGTC_3220 9131269 49.47 µM -0.747130903380076 0.220879629044465 no 2648 0.227492273824564 863 17722206
SGTC_3053 9095903 49.47 µM -0.748067518746419 0.220595100849689 no 2649 0.227209716382795 896 17174018
SGTC_643 k048-0106 28.4 µM -0.749153484531972 0.220265465507188 no 2650 0.226882350779709 855 6763920
SGTC_367 0335-0881 7.1 µM -0.749545694807685 0.220146482991962 no 2651 0.226764183981107 863 23828853
SGTC_657 3534-0529 86.7 µM -0.750013290730049 0.220004679361281 no 2652 0.226623350060498 866 1049549
SGTC_2346 9031566 143.75 µM -0.750285951268076 0.219922016234459 no 2653 0.226541250980583 850 4771086
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.753717924675449 0.218883062089364 no 2654 0.225509308190698 848 2724 A muscle relaxant with antifungal properties.
SGTC_1854 st056233 32.9 µM -0.754729211896434 0.218577456693493 no 2655 0.22520573761357 867 5393174
SGTC_2234 tolnaftate 200 µM -0.755110008241324 0.218462445844588 no 2656 0.22509148928961 865 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3169 9102970 49.47 µM -0.755851553998413 0.218238578908132 no 2657 0.224869101486191 865 17027839
SGTC_2406 ethylparaben 405.7 µM -0.755859155349335 0.218236284803645 no 2658 0.224866822504326 858 8434 A possible steroid mimic.
SGTC_2398 5228213 48.84 µM -0.756093279712372 0.218165632359438 no 2659 0.224796635449824 854 80771 YMR134W ERG29
SGTC_85 0868-0259 160.055 µM -0.7569514115199 0.217906783959942 no 2660 0.224539486334094 829 83173
SGTC_1972 st070201 17.4 µM -0.757089753695924 0.217865070764254 no 2661 0.224498046129386 859 2829099
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.758727963608227 0.217371464867281 no 2662 0.224007652738284 855 688761
SGTC_2630 antimycin a 100 µM -0.760828199042954 0.216739592524345 no 2663 0.223379844509365 876 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_864 0469-0573 172 µM -0.7614674252789 0.216547487333938 no 2664 0.223188964138315 880 689425
SGTC_1233 0325-0408 14.2 µM -0.761847342618348 0.216433358338807 no 2665 0.223075560419981 857 12874
SGTC_1840 st055363 71 µM -0.76239009334135 0.216270373814314 no 2666 0.222913608559691 871 676033
SGTC_1442 4112-3290 3 µM -0.762521744668779 0.216230850484809 no 2667 0.222874335101713 867 704353
SGTC_629 3448-6466 76.7 µM -0.764943402986694 0.215504585521254 no 2668 0.222152623595892 869 573744
SGTC_1960 st011366 51.8 µM -0.765391978969273 0.215370211279401 no 2669 0.222019083904467 866 3972846
SGTC_1977 st070720 65.3 µM -0.765581413194532 0.215313479463444 no 2670 0.221962703684158 846 682188
SGTC_2427 5545055 42.75 µM -0.765962408863753 0.215199405033902 no 2671 0.221849334890794 852 5372858
SGTC_1111 tnp00062 510.699 nM -0.767575973531693 0.214716674496825 no 2672 0.221369570555217 856 676306
SGTC_2835 9006588 71.43 µM -0.771524553292814 0.213538034400526 no 2673 0.220198037308671 829 2345538
SGTC_105 0111-0055 734.78 µM -0.772169796402228 0.213345790142703 no 2674 0.220006933919009 863 5179370
SGTC_1953 st076800 12.1 µM -0.772983707454579 0.213103436790352 no 2675 0.219766011462475 854 297591
SGTC_1235 benzylparaben 21.5 µM -0.773168908177211 0.213048313132531 no 2676 0.219711212119659 867 7180
SGTC_1452 4194-0072 190 µM -0.775599131640191 0.212325745797625 no 2677 0.218992856631545 884 1343545
SGTC_1329 1447-1697 50.6 µM -0.776050983904237 0.212191556680598 no 2678 0.218859441643647 872 2840515
SGTC_382 3229-0966 23.2 µM -0.777495831756713 0.211762804918038 no 2679 0.218433146355273 875 5722370
SGTC_385 1494-0393 12.4 µM -0.778196165399561 0.211555166773749 no 2680 0.218226688538563 876 3090647
SGTC_850 0388-0143 75.9 µM -0.778976203933121 0.211324037732757 no 2681 0.217996866203587 867 67273
SGTC_910 3454-3003 490 µM -0.781062902309288 0.210706466906557 no 2682 0.217382749785804 877 820824
SGTC_2299 7976368 114.88 µM -0.781373395199164 0.210614665258957 no 2683 0.217291457018137 866 2979718
SGTC_3156 9099931 49.47 µM -0.782752355075735 0.210207239778613 no 2684 0.216886275545624 881 18111053
SGTC_218 alverine citrate 93.75 µM -0.784138558369132 0.209798141090857 no 2685 0.216479406292121 859 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_580 1123-0028 41 µM -0.785517267947538 0.209391718601811 no 2686 0.216075174982649 891 1677248 YPR107C YTH1
SGTC_2949 9072542 2.23 µM -0.78600477800994 0.209248119041829 no 2687 0.215932343970043 887 16457352
SGTC_2058 5236698 133 µM -0.786242071875399 0.20917824342449 no 2688 0.215862841259115 855 766665
SGTC_1628 st004252 77.7 µM -0.787632060795292 0.208769211188833 no 2689 0.215455977852939 860 692968
SGTC_1187 1391-0724 117 µM -0.787958040695913 0.208673353312346 no 2690 0.215360624769555 874 6997986
SGTC_225 nsc-122657 1.016 µM -0.788474449800973 0.208521550805235 no 2691 0.215209618957189 868 275685
SGTC_1608 st001473 40.5 µM -0.788610941282921 0.20848143894563 no 2692 0.215169717059475 880 7292267
SGTC_231 b-estradiol 524 µM -0.788764689716245 0.208436261095455 no 2693 0.215124775410984 872 450 A steroid.
SGTC_422 cantharidin 155 µM -0.789365596416836 0.208259744455016 no 2694 0.214949178824242 877 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1243 0416-0003 5.65 µM -0.789589872231036 0.208193885931627 no 2695 0.214883662421993 872 2141977
SGTC_1297 1068-0111 14.1 µM -0.790314424797813 0.207981205295293 no 2696 0.214672082337867 858 767057
SGTC_909 3448-9333 149 µM -0.790553566934836 0.207911037169539 no 2697 0.21460227587437 878 3344074
SGTC_1174 0739-0097 51.1 µM -0.791169327065235 0.207730427650434 no 2698 0.214422593979687 879 728447
SGTC_173 1273-0061 2.693 µM -0.791479492817799 0.207639487583007 no 2699 0.214332119199067 859 2847414 YPL266W DIM1
SGTC_302 1094-0063 18.9 µM -0.791717547856914 0.207569706210984 no 2700 0.214262694044406 880 5440289
SGTC_2787 5284540 71.43 µM -0.791917852646064 0.207511001354623 no 2701 0.214204288315471 870 736958
SGTC_2243 6634756 200 µM -0.793662338180939 0.207000146646765 no 2702 0.213696015510678 849 885676
SGTC_2145 5634607 200 µM -0.795337798577709 0.206510206520115 no 2703 0.213208515888914 880 308662
SGTC_2449 5812982 45.77 µM -0.795682510701763 0.206409490662113 no 2704 0.213108297378367 869 776185
SGTC_1676 st018489 23.4 µM -0.796395426895915 0.206201287577432 no 2705 0.212901117723895 866 3696235
SGTC_1756 st041558 35.5 µM -0.796519457402916 0.20616507789751 no 2706 0.212865085386453 897 3955792
SGTC_2754 granisetron 64.02 µM -0.797141412346936 0.205983560154984 no 2707 0.212684453760299 870 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2344 7990960 76.95 µM -0.7972574434237 0.205949706943762 no 2708 0.212650765276192 870 140813
SGTC_3037 9091026 49.47 µM -0.797450036854425 0.205893523196058 no 2709 0.212594854543312 862 25236398 YIL048W NEO1
SGTC_245 methotrexate 289.6 µM -0.798390289381713 0.205619361394958 no 2710 0.212322018335077 844 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2917 7979103 53.79 µM -0.798606537981664 0.205556337610177 no 2711 0.21225929771394 859 2980565
SGTC_1494 4358-1428 177 µM -0.800164293599027 0.205102682168572 no 2712 0.211807807243449 869 1564571
SGTC_1384 3089-0840 101 µM -0.802823836382385 0.204329536702707 no 2713 0.211038281433169 861 1069836
SGTC_62 0180-0423 3.232 µM -0.803560659969139 0.204115644889436 no 2714 0.210825375367571 879 30102 YGL099W LSG1
SGTC_3022 9087993 49.47 µM -0.803564600021252 0.204114501494089 no 2715 0.210824237223456 885 17173644
SGTC_373 0844-0104 25.9 µM -0.804075402345445 0.203966299978652 no 2716 0.210676714703757 854 5375804
SGTC_1279 0874-0590 65.2 µM -0.807225079061334 0.203053886727483 no 2717 0.209768409669278 872 3523074
SGTC_965 1291-5240 308 µM -0.808283610890964 0.202747794216596 no 2718 0.209463667500667 890 2834598
SGTC_3046 9092212 49.47 µM -0.81204119040737 0.201663454626794 no 2719 0.208383998286125 896 25236637
SGTC_3313 9133968 57.047 µM -0.812131352429202 0.201637478962943 no 2720 0.208358132329063 866 1494643
SGTC_1746 st038117 42 µM -0.81266408067319 0.201484040952836 no 2721 0.208205340275363 850 2898218
SGTC_424 splitomicin 100 mM -0.814798182707201 0.200870072289113 no 2722 0.2075939206735 895 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1863 st057641 20.1 µM -0.814905373785575 0.200839263682593 no 2723 0.207563238470568 891 3921635
SGTC_1899 st063254 59.6 µM -0.816934301067988 0.200256649162816 no 2724 0.206982987151189 874 3093813
SGTC_2777 climbazole 1.536 µM -0.817726775328059 0.200029363116042 no 2725 0.206756608990205 882 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_27 0485-0001 32.618 µM -0.818419660705361 0.199830766851466 no 2726 0.206558799548834 855 2054479
SGTC_3004 9076122 71.4286 µM -0.81850770076522 0.199805541118819 no 2727 0.206533673326761 891 44782551
SGTC_3349 9149703 23.001 µM -0.820049396399935 0.199364116338822 no 2728 0.206093974101006 866 4910494
SGTC_1036 k216-0215 33.5 µM -0.8207947428632 0.199150916331301 no 2729 0.205881596795725 835 622330
SGTC_1611 st001856 99.4 µM -0.821269752321597 0.19901511560466 no 2730 0.205746316457579 887 647478
SGTC_2536 dehydroabietamide 32.04 µM -0.824323035359735 0.19814354359155 no 2731 0.204878016624257 880 3983547
SGTC_2495 cafestol 54.53 µM -0.825271601598956 0.197873241401214 no 2732 0.204608705375521 890 16667697 An anti-infammatory.
SGTC_1085 doxorubicin 7.67 µM -0.825627347424692 0.19777192600211 no 2733 0.204507758484121 869 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1269 0831-0796 3.05 µM -0.829787323781269 0.196589504445683 no 2734 0.203329519527867 853 927758
SGTC_2152 5568786 200 µM -0.830215114971508 0.196468153457402 no 2735 0.203208585441597 883 5399883
SGTC_2273 7815444 169.05 µM -0.831137623644354 0.196206621123002 no 2736 0.202947943754465 896 2824616
SGTC_1251 0490-5699 265 µM -0.833160094319579 0.195633987414875 no 2737 0.202377222624109 868 3883818
SGTC_973 1325-0077 65.9 µM -0.834505195238844 0.195253703711442 no 2738 0.201998180506864 887 2835149
SGTC_53 0973-0023 39.979 µM -0.834750489884362 0.195184403054464 no 2739 0.20192910364871 887 674768
SGTC_951 1171-0579 82.7 µM -0.83492593976028 0.195134844116562 no 2740 0.201879704290187 876 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1515 3460-0031 42.1 µM -0.835567568641857 0.194953669765324 no 2741 0.201699110011344 872 2876596
SGTC_993 3909-8757 62.7 µM -0.838542494080596 0.194114988474871 no 2742 0.200863046108723 868 4288324 YLR208W SEC13
SGTC_1964 st076914 61 µM -0.840269267148136 0.193629191915154 no 2743 0.20037871441931 910 24208661
SGTC_1796 st049173 110.4 µM -0.84093953224167 0.19344082479795 no 2744 0.200190905158239 891 94134
SGTC_573 3702-0553 84.7 µM -0.841153655148827 0.193380672602321 no 2745 0.200130929909115 875 1222756
SGTC_1741 st038134 10.228 µM -0.841331032860806 0.193330851646327 no 2746 0.200081255069953 892 1272587
SGTC_3255 9139072 49.47 µM -0.841801133823484 0.193198849953352 no 2747 0.199949638593293 881 17646060
SGTC_2146 5545642 200 µM -0.842058261570082 0.193126673215588 no 2748 0.199877671304898 883 825326
SGTC_2867 9039098 71.43 µM -0.842797334920516 0.192919304188287 no 2749 0.199670899388026 877 6463460
SGTC_1373 2887-0003 58.5 µM -0.84375739167424 0.192650134846816 no 2750 0.199402494799406 897 776948
SGTC_966 1300-0360 30.2 µM -0.844584740019985 0.192418356932762 no 2751 0.199171366055807 861 70588
SGTC_2621 lithochol-11-enic acid 100 µM -0.844750096849669 0.192372053413613 no 2752 0.199125191186968 895 6708711
SGTC_2222 6885208 172.143 µM -0.844956713114149 0.192314205929623 no 2753 0.19906750394113 885 609514
SGTC_646 4092-0839 27.3 µM -0.846471315783286 0.191890479256733 no 2754 0.198644934512503 883 877796
SGTC_2952 9073731 13.78 µM -0.846550265102779 0.191868408003056 no 2755 0.198622922742096 901 16457353
SGTC_607 4491-0986 66.8 µM -0.846956758611375 0.191754792343359 no 2756 0.198509612034543 864 698981 YDR232W HEM1
SGTC_2544 sphondin 68.51 µM -0.847165172586654 0.191696556244979 no 2757 0.198451531434948 869 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1491 4138-0063 26.5 µM -0.849283644430425 0.191105216793728 no 2758 0.197861739766582 885 23883227
SGTC_393 acivicin 6.25 µM -0.849388647080956 0.191075936012299 no 2759 0.197832534147782 871 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2978 9011784 42.97 µM -0.850049233295047 0.190891789666619 no 2760 0.197648857297147 870 2994934
SGTC_520 3584-0023 682 µM -0.852126265840264 0.19031350157048 no 2761 0.197072007606203 884 1340790
SGTC_1832 st054113 55 µM -0.852211416927733 0.190289816761217 no 2762 0.197048380543545 888 1251267
SGTC_980 1473-0395 201 µM -0.852464059695094 0.190219554730271 no 2763 0.196978289279832 888 768876
SGTC_504 lovastatin 124 µM -0.852685773982184 0.190157907297403 no 2764 0.196916791010731 891 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2248 tofa 1.1 µM -0.854684832790707 0.189602625524521 no 2765 0.196362824698826 875 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2280 7785178 200 µM -0.855129717182895 0.189479185109203 no 2766 0.196239669825539 875 2954328
SGTC_2074 5212007 75.395 µM -0.855231979655992 0.189450817713566 no 2767 0.196211367694638 862 758611
SGTC_3238 9133470 49.47 µM -0.855274508236527 0.189439021144009 no 2768 0.19619959822636 869 3534688
SGTC_1859 st055998 20 µM -0.855578381258714 0.189354746057933 no 2769 0.196115516085489 904 676301
SGTC_1995 st072814 61.1 µM -0.856538093767086 0.189088734300644 no 2770 0.195850105668121 892 5769371
SGTC_2991 9074669 71.4286 µM -0.863542678956671 0.18715419078876 no 2771 0.193919582257804 876 17333109
SGTC_322 k048-0136 19.3 µM -0.86359560099172 0.187139621398061 no 2772 0.19390504077525 903 6823282
SGTC_1581 himbacine 57.9 µM -0.863616403948108 0.18713389455414 no 2773 0.193899324891549 912 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_766 1391-0721 126 µM -0.864726897096753 0.186828344342834 no 2774 0.193594351477211 919 1020919 YIL115C NUP159
SGTC_3134 9127454 49.47 µM -0.864741334144978 0.186824374048974 no 2775 0.193590388575083 905 24262820
SGTC_357 1325-0123 420 µM -0.866162755605099 0.186433728444616 no 2776 0.193200457301181 921 1098503
SGTC_680 0417-1641 114 µM -0.870198474006011 0.185327362651415 no 2777 0.192095974869144 892 2835990
SGTC_2364 9055074 200 µM -0.871816192783394 0.184885022534308 no 2778 0.191654329677098 903 6470630
SGTC_356 1634-0012 32.5 µM -0.873273438734098 0.184487123456839 no 2779 0.191257027232383 902 735457
SGTC_598 3937-0236 20.2 µM -0.873434232841358 0.184443251490542 no 2780 0.191213219395968 903 1379313
SGTC_2761 levamisole 97.89 µM -0.879467097552261 0.182801902848148 no 2781 0.189574032694121 877 26879 An alkaline phosphatase inhibitor.
SGTC_1924 st058459 75.1 µM -0.880793748378266 0.182442190446504 no 2782 0.189214732031292 875 688683
SGTC_3070 9117005 49.47 µM -0.884230493543789 0.181512398507224 no 2783 0.188285900232914 912 8779016
SGTC_230 MPP+ 141.667 µM -0.886397099537938 0.180927762620747 no 2784 0.187701790812235 901 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2895 9054447 58.44 µM -0.886939442551254 0.180781601929005 no 2785 0.187555752380242 916 2697450
SGTC_2926 9010726 65.15 µM -0.888675368039592 0.180314270226186 no 2786 0.187088786394854 927 2994293
SGTC_2564 betulinic acid 100 µM -0.889094692680942 0.180201496842448 no 2787 0.18697609550449 917 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_162 k030-0015 37.8 µM -0.88944214476973 0.180108086445347 no 2788 0.186882751738475 919 1809920 YMR134W ERG29
SGTC_882 0843-0131 351 µM -0.889956565324039 0.179969843413832 no 2789 0.186744604491515 899 5425421
SGTC_1063 disulfiram 1.84 µM -0.890426685973907 0.17984356362496 no 2790 0.1866184092475 924 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2990 9074105 71.4286 µM -0.891325916598992 0.179602175070854 no 2791 0.186377174454399 909 6502001
SGTC_3091 9116372 49.47 µM -0.894825790037598 0.178664612288479 no 2792 0.185440110803905 915 17169793
SGTC_2892 9047358 58.44 µM -0.895930284824679 0.178369375853387 no 2793 0.185144999128647 897 6466771
SGTC_1262 0737-0114 49.6 µM -0.896128702571883 0.178316370483885 no 2794 0.185092014508679 915 765919
SGTC_2619 obliquin 87.91 µM -0.897788269635648 0.177873422057553 no 2795 0.184649219812059 892 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1723 st034307 2.5525 µM -0.897830463290803 0.177862169371192 no 2796 0.184637970572907 895 867466
SGTC_1475 4092-1048 11.7 µM -0.903914205671559 0.176244388637197 no 2797 0.18302044796484 925 2881759
SGTC_1108 betulinic acid 729.144 nM -0.906219422141682 0.175633829015157 no 2798 0.18240986247134 881 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_463 ikarugamyin 104 µM -0.909983552894946 0.174639746226831 no 2799 0.181415591829182 935 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1216 1165-0504 9.65 µM -0.911565133341265 0.174223128973794 no 2800 0.180998841877564 914 6304004
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.915742173281862 0.173125859959507 no 2801 0.179901069851424 904 551469
SGTC_2519 cryptotanshinone 88.04 µM -0.916565657666877 0.172910058910608 no 2802 0.179685143571767 902 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_588 3970-1144 52.9 µM -0.918266309745042 0.172464931432376 no 2803 0.179239730351565 880 1888707
SGTC_1828 st055811 49 µM -0.919287722976265 0.172197939061163 no 2804 0.178972548818829 906 5877589
SGTC_2964 9083345 53.42 µM -0.922653814372431 0.171319927525324 no 2805 0.178093820874512 894 17741579
SGTC_2188 6126565 140.678 µM -0.922675669069979 0.171314236311645 no 2806 0.178088124543741 896 874518
SGTC_1926 methyl fluorone black 53.6 µM -0.923558172111641 0.171084523391754 no 2807 0.177858199979652 847 72721 Reacts with homocysteine.
SGTC_1467 k284-1082 293 µM -0.923931528376703 0.1709873991965 no 2808 0.17776098330081 909 3334705
SGTC_2676 harmalol 100 µM -0.923966614914173 0.170978273664231 no 2809 0.177751848987348 886 5459187 A monoamine oxidase inhibitor
SGTC_2533 agelasine 13.65 µM -0.924361695486783 0.170875540075299 no 2810 0.177649015454139 872 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_407 eburnamonine 100 µM -0.926889455277664 0.170219176710697 no 2811 0.17699196631619 889 3195
SGTC_2601 securinine 100 µM -0.928236580873186 0.169870040007241 no 2812 0.176642431458362 917 442872 A GABA receptor antagonist.
SGTC_1822 st052468 42 µM -0.930682271070109 0.169237360932984 no 2813 0.176008971575347 909 2873678
SGTC_1385 3091-4834 14.1 µM -0.931318418904191 0.169073043186058 no 2814 0.175844438498801 899 4072814
SGTC_2305 7443522 69.23 µM -0.931556492903491 0.169011574743256 no 2815 0.175782888172986 885 5415886
SGTC_277 nystatin 15.5 µM -0.931814452676677 0.168944988186875 no 2816 0.175716212096767 932 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2046 4110841 106 µM -0.931889996279028 0.168925491483042 no 2817 0.175696689020059 905 44119630 YMR134W ERG29
SGTC_2296 7971656 126.45 µM -0.935259597285473 0.168057316811827 no 2818 0.174827265756771 896 666570
SGTC_273 hydroxyurea 18.1 mM -0.93678194061977 0.167666029762398 no 2819 0.174435368341866 930 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2543 pimpinellin 60.67 µM -0.937219963931413 0.167553553662979 no 2820 0.174322711296678 899 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1954 st077032 68.9 µM -0.93819666989078 0.167302929118819 no 2821 0.174071674717532 925 698907
SGTC_1704 st028805 70.8 µM -0.939963569744072 0.166850153607207 no 2822 0.173618123813497 910 2876101
SGTC_1624 st003710 6.25 µM -0.942988176803898 0.166076921889006 no 2823 0.17284347523613 932 24207033
SGTC_2138 5575593 77.673 µM -0.945600920031658 0.165410848749119 no 2824 0.17217608740535 909 762213
SGTC_1673 st016611 27.3 µM -0.945773808747527 0.165366834846467 no 2825 0.172131983545758 939 5226799
SGTC_160 3453-0671 289.699 µM -0.948969827350735 0.164554559397271 no 2826 0.171317979065486 938 5322268
SGTC_1093 fluphenazine 7.97 µM -0.9493050494244 0.164469512018852 no 2827 0.171232743076846 935 6602611 An atypical antipsychotic.
SGTC_33 0986-0033 35.816 µM -0.950209177139402 0.164240272743561 no 2828 0.171002988242125 865 2848082
SGTC_1944 st076371 56.9 µM -0.950748029372413 0.164103746725559 no 2829 0.170866150198792 907 24208455
SGTC_2409 alverine citrate 63.97 µM -0.951391572834457 0.163940792153672 no 2830 0.170702818328222 904 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_293 4049-0273 38.5 µM -0.951494389839389 0.163914767122108 no 2831 0.170676732547907 894 1380311
SGTC_1266 0828-0227 32.9 µM -0.951541243670383 0.163902908373617 no 2832 0.170664846073303 929 3913820
SGTC_1246 0422-0085 105 µM -0.951549349999016 0.163900856710745 no 2833 0.170662789610728 917 264295
SGTC_300 r073-0011 5.04 µM -0.951706394002711 0.163861113109653 no 2834 0.17062295286652 917 2735780
SGTC_2675 theaflavin digallate 100 µM -0.952985353370288 0.163537675887319 no 2835 0.170298745879363 931 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_63 0099-0242 26.702 µM -0.957948941421485 0.162286359024336 no 2836 0.169044252863986 916 3898502 YLR359W ADE13
SGTC_397 arbidol 50 µM -0.958178467099819 0.162228646944955 no 2837 0.168986386669871 917 131410 A RNA synthesis inhibitor.
SGTC_1453 4237-0541 195 µM -0.960406567401929 0.161669106566288 no 2838 0.1684253170472 899 739892
SGTC_46 0329-0187a 2.197 µM -0.960664175292651 0.16160449500163 no 2839 0.168360524797538 903 46494817
SGTC_1645 Cervolide 78 µM -0.962197999618781 0.161220139528176 no 2840 0.167975076892933 920 23173 A fragrance.
SGTC_2956 9076196 2.52 µM -0.963223653023769 0.160963457758095 no 2841 0.167717648768484 932 16423868
SGTC_1525 8-methoxypsoralen 92.5 µM -0.963527111386698 0.160887564913753 no 2842 0.167641532667862 943 4114 Related to psoralen; DNA damaging agent.
SGTC_254 nsc-64875 3.808 µM -0.964614606210458 0.160615781841614 no 2843 0.167368940399546 923 56993
SGTC_3020 9089140 49.47 µM -0.966926592588796 0.160038974964316 no 2844 0.166790365873593 937 17217859
SGTC_304 1310-0298 97 µM -0.968538889114501 0.159637533149725 no 2845 0.166387653342058 921 1550234
SGTC_1302 1159-0335 255 µM -0.96874672155074 0.159585833443004 no 2846 0.166335787564302 915 649284
SGTC_1055 3448-0672 86 µM -0.969966152603961 0.159282712620311 no 2847 0.166031681909067 915 748378
SGTC_3322 9139058 2.11 µM -0.969992335569333 0.159276208311094 no 2848 0.166025156258693 908 4908926 YPR165W RHO1
SGTC_327 1273-0057 3.96 µM -0.97053757785286 0.159140800061849 no 2849 0.165889301729393 898 3108138
SGTC_2699 st077704 54.6 µM -0.971060223805694 0.159011074306359 no 2850 0.165759144849199 918 645852
SGTC_292 k038-0015 474 µM -0.971266170761542 0.158959975325885 no 2851 0.165707875087975 930 46368540
SGTC_675 1309-0189 238 µM -0.97206713877403 0.158761343707608 no 2852 0.16550857444904 916 4246530
SGTC_2121 5257820 149.641 µM -0.972440208085731 0.158668882019421 no 2853 0.165415798532287 913 791256
SGTC_703 3875-0075 71.8 µM -0.972687136658335 0.15860770253845 no 2854 0.16535441015432 950 2850814
SGTC_2905 7799065 20.05 µM -0.974373118382908 0.158190394009721 no 2855 0.164935655873895 905 1296806
SGTC_1238 0333-0287 48.8 µM -0.974852133197659 0.158071961438571 no 2856 0.164816806359661 919 7226
SGTC_748 act1.228 77.9 µM -0.975851342103179 0.157825102433664 no 2857 0.164569068831847 918 4421505 YNR035C ARC35
SGTC_3021 9087658 49.47 µM -0.976418526201509 0.157685089787743 no 2858 0.16442855222208 916 25237042
SGTC_2080 5212524 12.4 µM -0.978113373354411 0.157267193412449 no 2859 0.164009127134869 911 260183
SGTC_2240 6690706 185.951 µM -0.979654585097374 0.156887811436182 no 2860 0.163628325432904 923 805876
SGTC_754 3474-0146 171 µM -0.98368275044464 0.155899091238506 no 2861 0.162635761865712 904 24762078
SGTC_972 1319-0219 195 µM -0.98484727453029 0.155614023834857 no 2862 0.162349547680466 930 23903702
SGTC_1546 5-methoxyflavanone 78.7 µM -0.985314312270181 0.155499792897003 no 2863 0.162234852334267 911 147795
SGTC_1118 chelidonine 707.474 nM -0.986026416798433 0.155325728535281 no 2864 0.162060074938083 914 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1635 st007035 42.4 µM -0.987746245294707 0.154905870122295 no 2865 0.161638469876946 895 3716403
SGTC_2462 5162487 171.77 µM -0.987848850041299 0.154880845140347 no 2866 0.161613339592664 939 2259986
SGTC_916 4466-0038 42 nM -0.987961468591896 0.154853380896599 no 2867 0.161585759627349 939 5722064 YGL116W CDC20
SGTC_2306 7482397 179.52 µM -0.992591606837157 0.153727015853052 no 2868 0.160454508327381 973 891448
SGTC_1783 st039459 87.517 µM -0.992930725557522 0.153644732786794 no 2869 0.16037185753976 937 729761
SGTC_354 2783-3500 4.88 µM -0.993364968100247 0.153539411658198 no 2870 0.160266063585355 915 6740761
SGTC_2051 5263410 176 µM -0.993451719591228 0.153518376694389 no 2871 0.160244933898666 918 227584
SGTC_3014 9081533 49.47 µM -0.994037996825995 0.153376269859269 no 2872 0.160102184616547 938 21367265
SGTC_2227 7312221 64.1025 µM -0.994216825637127 0.153332941169001 no 2873 0.160058659167711 944 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_828 2074-0507 139 µM -0.997341432015417 0.15257718456296 no 2874 0.159299404674434 922 X828
SGTC_2016 5121758 140 µM -1.00086776384082 0.151727235035224 no 2875 0.158445371589852 918 2795203
SGTC_2256 7954252 200 µM -1.00213048219754 0.15142364939268 no 2876 0.158140288757169 968 2972920
SGTC_2482 5981709 142.65 µM -1.00475948424684 0.150792875456335 no 2877 0.157506338713516 948 877755
SGTC_2334 9017922 200 µM -1.00797890600018 0.150022828731115 no 2878 0.156732294468103 930 3163164
SGTC_2623 humulene 100 µM -1.0111613050825 0.149264218619308 no 2879 0.155969616260818 946 6187145 An anti-inflammatory.
SGTC_1463 k081-0032 34.1 µM -1.01159299266648 0.149161511949193 no 2880 0.155866348860913 888 977755
SGTC_1128 3448-9350 235 µM -1.01252980783286 0.148938788223471 no 2881 0.15564240098444 913 619386
SGTC_782 0083-0095 30.5 µM -1.01260513356469 0.148920889515105 no 2882 0.155624403413049 944 3591729 An indicator and reagent.
SGTC_1663 st014140 55.4 µM -1.01806503108781 0.14762734966239 no 2883 0.154323526141165 934 4207120
SGTC_2000 st075254 36.4 µM -1.01895112918064 0.147418130342916 no 2884 0.154113084206111 915 17234175
SGTC_2636 apigenin dimethyl ether 100 µM -1.01968951392437 0.147243939906185 no 2885 0.153937868200521 944 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_352 k048-0007 5.11 µM -1.01991442334064 0.147190909529833 no 2886 0.153884524218685 953 6811911
SGTC_2592 piperlongumine 83.33 µM -1.02218446035661 0.146656384538908 no 2887 0.153346802103866 959 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2487 5918373 44.05 µM -1.02274975677805 0.146523477178082 no 2888 0.153213089572575 926 2876279
SGTC_2135 5326629 150.42 µM -1.02421678843651 0.146178939264352 no 2889 0.152866445396479 944 5020077
SGTC_1831 st055328 12 µM -1.02711146007746 0.145500711969104 no 2890 0.152183991483634 932 1103068
SGTC_2993 9054257 71.4286 µM -1.02933804916286 0.144980459954372 no 2891 0.151660424727541 912 6470217 YGL055W OLE1
SGTC_1030 k029-0042 36.7 µM -1.03054554646507 0.144698847404281 no 2892 0.15137699149946 931 6080581
SGTC_688 0527-0193 473 µM -1.03099950335632 0.144593070922937 no 2893 0.151270526348709 960 4007154
SGTC_508 roscovitine 141 µM -1.03101836485987 0.144588677131992 no 2894 0.151266103894682 950 160355 A CDKinase inhibitor.
SGTC_2934 9036370 36.88 µM -1.03145048699831 0.144488038831088 no 2895 0.151164807834002 910 6462800
SGTC_3276 9139060 49.47 µM -1.03378277917775 0.143945678840233 no 2896 0.150618862004568 954 4870619
SGTC_2784 7567673 72.73 µM -1.03506206967917 0.143648771728182 no 2897 0.150319962472745 920 3471247
SGTC_2 0422-0095 29 µM -1.03620323792333 0.143384270053554 no 2898 0.150053668258489 918 6790840
SGTC_2705 st078069 42.8 µM -1.03703266081077 0.143192231674812 no 2899 0.149860318025112 946 1530061
SGTC_2684 capsaicin 100 µM -1.04042697663631 0.142408147986953 no 2900 0.149070786958945 939 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1080 nisoldipine 24.4 µM -1.04106912642763 0.142260139324164 no 2901 0.148921733532095 941 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.04198194207448 0.142049924276326 no 2902 0.148710025590583 943 616764
SGTC_223 busulfan 5 mM -1.04431403077456 0.141513815812769 no 2903 0.148170061731993 920 2478 A DNA alkylator.
SGTC_2827 7993847 71.43 µM -1.04736242519955 0.140815110316072 no 2904 0.147466227391614 906 2985692
SGTC_3145 9085516 49.47 µM -1.04754156023797 0.140774124711169 no 2905 0.147424937258886 954 25236195
SGTC_418 lividomycin a 100 µM -1.05025345420704 0.140154639606036 no 2906 0.14680079953304 924 72394 An antibiotic.
SGTC_499 genistein 192 µM -1.05145699066291 0.139880306782973 no 2907 0.146524376430497 968 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_402 epigallocatechin gallate 10 µM -1.05175452332447 0.139812543805985 no 2908 0.146456094297333 939 65064 An antioxidant.
SGTC_1184 1269-1718 139 µM -1.05341011738753 0.139435890310068 no 2909 0.146076534602748 923 5403821
SGTC_1659 st012954 42.1 µM -1.05378337085671 0.139351069264623 no 2910 0.145991054284909 948 24207262
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.05555610416457 0.1389486987855 no 2911 0.145585532242743 949 676296 Flavone; oxidizing agent.
SGTC_886 0866-0150 153 µM -1.05746447992881 0.138516425476423 no 2912 0.145149828614761 940 271463
SGTC_86 0417-1630 471.922 µM -1.05783262067133 0.138433142095086 no 2913 0.145065879019945 932 3634867
SGTC_2912 7964298 10.93 µM -1.0601238546003 0.137915570288439 no 2914 0.144544128352861 930 2975850
SGTC_1790 st045711 43.5 µM -1.06405131664701 0.137031461381317 no 2915 0.143652726591979 880 585119
SGTC_1751 st044839 27.194 µM -1.06466758356913 0.136893086149318 no 2916 0.143513192196396 929 5291326
SGTC_1411 3909-8223 150 µM -1.06475577127895 0.136873292486797 no 2917 0.143493232329592 939 X1411
SGTC_545 4218-0007 221 µM -1.06539001785069 0.13673099396539 no 2918 0.143349736047382 956 2840508
SGTC_616 4092-0450 108 µM -1.06635330313033 0.136515066375674 no 2919 0.143131981198804 960 787165
SGTC_2314 7727897 200 µM -1.06698736879214 0.136373063169044 no 2920 0.142988769895815 912 900724
SGTC_3245 9134821 49.47 µM -1.06775172958353 0.136202013882557 no 2921 0.142816258635651 953 17014901
SGTC_3311 9131146 2.8755 µM -1.06789297252244 0.136170422500278 no 2922 0.142784396429127 946 4900406 YPR165W RHO1
SGTC_1800 st050079 29.0735 µM -1.06886711561929 0.135952675417169 no 2923 0.142564775782901 943 3645560
SGTC_677 0929-0063 136 µM -1.0744102486599 0.13471817533513 no 2924 0.141319425557412 981 1539583
SGTC_1113 artemisinin 1.17947 µM -1.07508517825007 0.134568390119924 no 2925 0.141168297351776 937 2240 An anti-malaria and mitochondrial poison.
SGTC_1583 clindamycin 39.6 µM -1.07542455020252 0.134493117469136 no 2926 0.141092347622329 960 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2854 9024559 71.43 µM -1.07584397809938 0.134400128365268 no 2927 0.14099852006836 959 3163529
SGTC_1780 st038448 24.544 µM -1.07643867081831 0.134268357924891 no 2928 0.14086555768885 956 728868 YDL195W SEC31
SGTC_1909 st060837 51.5 µM -1.07695502546107 0.134154017416541 no 2929 0.140750179279938 937 678937
SGTC_2980 9014342 25.29 µM -1.07887134891972 0.133730255545463 no 2930 0.140322541368569 926 2996599
SGTC_1414 3917-0015 5.4 µM -1.07998934793692 0.133483454836378 no 2931 0.140073461821525 946 6618702
SGTC_1448 4255-0083 152 µM -1.08175952897973 0.133093324554753 no 2932 0.139679697005543 968 5399660
SGTC_2635 hydroquinidine 100 µM -1.08281249040921 0.132861634947178 no 2933 0.139445830174885 937 442912 An experimental heart treatment.
SGTC_810 3825-7150 143 µM -1.08545176111717 0.132282120892834 no 2934 0.138860808910689 922 22330411 YGL099W LSG1
SGTC_665 3914-0008 307 µM -1.0867459891184 0.131998580274298 no 2935 0.138574541678057 954 1069549
SGTC_1640 st009078 66.4 µM -1.08879369583329 0.131550823605845 no 2936 0.138122436135417 949 690618
SGTC_3165 9101544 49.47 µM -1.09172463538419 0.130911762993842 no 2937 0.137477076763968 960 5002184
SGTC_271 rotenone 740 µM -1.09286958680088 0.130662702032734 no 2938 0.137225531620042 954 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2104 5389443 200 µM -1.09662415563056 0.129848271098969 no 2939 0.136402861775449 964 2244536
SGTC_662 k832-1615 104 µM -1.09685060593298 0.129799262748388 no 2940 0.136353351980315 962 5878478
SGTC_2313 7726885 200 µM -1.09911178289611 0.129310601517176 no 2941 0.135859655509995 951 726423
SGTC_1133 3473-0247 50 µM -1.10624047713867 0.127778377296268 no 2942 0.13431122370193 925 711311
SGTC_1558 st069300 45.6 µM -1.10687267078132 0.12764310682537 no 2943 0.134174491608533 943 24208000
SGTC_983 1491-0821 12.2 µM -1.10797117131081 0.127408297513863 no 2944 0.133937133217727 946 46495113
SGTC_564 3555-0129 330 µM -1.11130492019934 0.126697533972218 no 2945 0.133218561138368 915 563260
SGTC_106 0092-0003 11.579 µM -1.11274428557016 0.126391512738941 no 2946 0.132909134909081 947 1072148
SGTC_2059 5238311 157 µM -1.11312691812613 0.126310248550081 no 2947 0.132826962155176 953 703021
SGTC_724 3910-0327 137 µM -1.11450957255923 0.126016901456153 no 2948 0.13253032005063 963 2885483
SGTC_1707 st032323 6.317 µM -1.11517472199113 0.125875951199361 no 2949 0.132387778051125 944 3132057 YMR211W DML1
SGTC_1286 0929-0070 131 µM -1.11531957821454 0.125845269642094 no 2950 0.132356749274507 954 1420408
SGTC_2245 6637752 200 µM -1.11713160953601 0.125461909460718 no 2951 0.131969028477881 970 681890
SGTC_404 fumagillin 50 µM -1.12000241146183 0.12485622172039 no 2952 0.13135636723531 948 12015870 A methionine aminopeptidase binder.
SGTC_1487 3970-0795 2.82 µM -1.12703118676619 0.123381909832911 no 2953 0.129864647724749 949 3765103
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.1277515361631 0.123231505754955 no 2954 0.129712432998067 968 15053
SGTC_2048 5246248 200 µM -1.13075658332149 0.122605458376847 no 2955 0.129078779200432 944 677046
SGTC_2880 9042983 58.44 µM -1.13109928244728 0.122534205186976 no 2956 0.129006653145482 960 6464714
SGTC_2442 5158906 48.48 µM -1.13165460755153 0.122418805004184 no 2957 0.128889836182574 937 1893835
SGTC_537 1334-0398 209 µM -1.1345420193861 0.121820011297428 no 2958 0.128283629194452 950 5846986
SGTC_2153 5569715 200 µM -1.13653615739873 0.121407668561674 no 2959 0.127866121002222 966 2054701
SGTC_151 3013-0144 2.285 µM -1.13656914846609 0.121400855015043 no 2960 0.127859221685788 953 906558 YHR107C CDC12
SGTC_740 k014-0057 261 µM -1.13909670147353 0.120879646146272 no 2961 0.127331411572227 965 4012779
SGTC_1740 st038286 13.222 µM -1.13945261770887 0.120806379032263 no 2962 0.127257210136267 940 716786
SGTC_1322 1348-1070 12 µM -1.13966831366313 0.120761992169003 no 2963 0.127212256473778 944 6758089
SGTC_1247 0448-0043 5.84 µM -1.1397484391047 0.120745506527374 no 2964 0.127195560171048 965 3089013 YGL099W LSG1
SGTC_3110 9122132 49.47 µM -1.14008526089654 0.120676223476364 no 2965 0.127125390916995 964 918317
SGTC_1189 1431-2119 7.28 µM -1.14050716824658 0.12058947811777 no 2966 0.1270375340059 960 3107275
SGTC_2459 5811157 9.22 µM -1.14129865915078 0.120426863781576 no 2967 0.126872829971418 956 2870684 YBR192W RIM2
SGTC_3029 9088683 49.47 µM -1.14196881098754 0.120289299738059 no 2968 0.126733492061628 963 25236615
SGTC_1307 1187-1599 12.2 µM -1.14437102616337 0.119797099711806 no 2969 0.126234899431537 963 1538471
SGTC_80 0159-0065 512.242 µM -1.14592261791386 0.119479943331538 no 2970 0.12591358586318 946 1548079
SGTC_1726 st035556 14.5795 µM -1.14606009769335 0.119451870084029 no 2971 0.12588514320067 952 5919439
SGTC_2844 9010103 25.97 µM -1.14650984720542 0.119360064153726 no 2972 0.125792127561852 974 2480525
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.14782834463092 0.119091210467673 no 2973 0.125519716801489 963 641818 YHR062C RPP1
SGTC_1934 st074720 32.6 µM -1.14790264306039 0.119076073073423 no 2974 0.125504378490502 948 17250992
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.14897271422985 0.118858209848767 no 2975 0.125283616011059 971 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2779 methotrexate 400 µM -1.14914386329818 0.118823390552872 no 2976 0.125248332035416 944 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_375 3970-0961 9.27 µM -1.15012594235455 0.118623731488662 no 2977 0.125046001416769 942 2898222
SGTC_706 4262-0057 46.9 µM -1.15862228979222 0.116906296309171 no 2978 0.123305089571219 985 883298
SGTC_2203 7227154 166.4 µM -1.15898321495959 0.116833731856544 no 2979 0.123231513474259 972 896304
SGTC_2998 9066762 71.4286 µM -1.15965608144112 0.116698536472295 no 2980 0.123094428995794 965 4945196
SGTC_3102 9121669 49.47 µM -1.16022819426373 0.11658367225225 no 2981 0.122977955376423 986 41905072
SGTC_3141 9094609 49.47 µM -1.16147006575268 0.116334615233586 no 2982 0.122725394851188 970 25236309 YDL196W YDL196W
SGTC_2120 5538279 151.968 µM -1.16201424028906 0.11622560019611 no 2983 0.122614840298304 977 2058197
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.16474116040282 0.115680405349919 no 2984 0.122061891268278 980 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_261 5-fluorouridine 15.376 µM -1.16480388027049 0.115667887134957 no 2985 0.122049193932108 981 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3298 9116858 71.43 µM -1.1658540268056 0.115458432037312 no 2986 0.121836734579352 994 2506942
SGTC_2490 carminic acid 95.39 µM -1.17132154544264 0.114372272342447 no 2987 0.12073477713032 949 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_642 0335-0876 158 µM -1.17178318300437 0.114280899074555 no 2988 0.120642058068197 971 6812350
SGTC_153 4077-0274 519.67 µM -1.17215191626095 0.114207951978054 no 2989 0.120568034687329 946 3121976
SGTC_3147 9097027 49.47 µM -1.17342711714977 0.113955932588249 no 2990 0.120312284056345 977 25236841
SGTC_3212 9128307 49.47 µM -1.17362380804806 0.113917095643406 no 2991 0.120272870338908 976 27243542
SGTC_1008 4106-0037 6 µM -1.1737711313512 0.1138880125905 no 2992 0.120243355058628 961 2905394
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.17466974332687 0.11371073240374 no 2993 0.12006343439693 978 140250 A respiratory chain inhibitor.
SGTC_1569 carminic acid 40.6 µM -1.17807570841357 0.113040581904248 no 2994 0.119383212633368 966 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1996 st072960 66.8 µM -1.18011251153559 0.112641174110464 no 2995 0.1189777345455 955 1719405
SGTC_848 0368-0089 85.6 µM -1.18357650958484 0.111964216392036 no 2996 0.118290371812769 962 762535
SGTC_328 k915-0120 63.5 µM -1.18806245740648 0.111091872161618 no 2997 0.117404401921487 962 6624543
SGTC_21 0849-0113 22.993 µM -1.18829084678078 0.111047589792321 no 2998 0.117359421309878 974 1560156
SGTC_526 4469-0568 170 µM -1.18851220787713 0.111004682199909 no 2999 0.117315836544959 963 2901964
SGTC_1064 honokiol 6.76 µM -1.18972541335347 0.11076973104056 no 3000 0.117077166744393 993 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1410 3909-8106 77.9 µM -1.19101687813612 0.110520015849538 no 3001 0.116823479520288 974 1039210
SGTC_3159 9100096 49.47 µM -1.19228077437762 0.110276022232958 no 3002 0.116575585202817 969 25236875
SGTC_3325 9138760 55.175 µM -1.19308493418288 0.11012098139709 no 3003 0.116418055615765 948 43844959
SGTC_811 0416-0114 265 µM -1.1936030373665 0.11002117472251 no 3004 0.116316642649446 951 6612453
SGTC_667 1498-1044 59 µM -1.19554664970697 0.109647338410954 no 3005 0.11593676069533 985 6739982
SGTC_2511 berberine 10.47 µM -1.19681757884916 0.109403380317993 no 3006 0.115688832494736 964 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_571 k831-0106 44.2 µM -1.20244722865514 0.108327442979415 no 3007 0.114595150114064 957 4783639
SGTC_721 1187-1332 279 µM -1.20356023426312 0.108115630254597 no 3008 0.11437979854646 987 25730
SGTC_2781 5567276 71.43 µM -1.20683068376229 0.107494966522614 no 3009 0.1137486783455 965 2853274
SGTC_2897 9048598 12.99 µM -1.20830056310043 0.107216851777803 no 3010 0.113465835978863 986 6467404
SGTC_1973 st070275 50.2 µM -1.21447202167265 0.106054817152261 no 3011 0.112283763730011 984 17118334
SGTC_995 3931-2021 34.6 µM -1.21594492953473 0.105778830857328 no 3012 0.112002950565391 997 730143
SGTC_903 1134-0042 114 µM -1.21883654442857 0.105238525006985 no 3013 0.11145311902378 964 701009
SGTC_2239 6685329 187.64 µM -1.2201095670361 0.105001291517591 no 3014 0.111211671153796 950 805680
SGTC_921 1561-0023 372 µM -1.2228538238116 0.104491204144298 no 3015 0.110692455966343 960 24050882
SGTC_815 1582-0027 36.9 µM -1.22732099775755 0.103664714349289 no 3016 0.109850983273936 977 3128206
SGTC_2216 7189485 200 µM -1.22855095513717 0.103437990001707 no 3017 0.109620106778736 967 731273
SGTC_398 bronopol 33.3 µM -1.23063495292933 0.1030546579631 no 3018 0.109229713168739 967 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2795 7780010 54.55 µM -1.23104247437838 0.10297981894742 no 3019 0.109153489420726 969 953673
SGTC_2123 5259487 200 µM -1.23206808901368 0.102791645334839 no 3020 0.108961825267284 983 2173474
SGTC_1851 st056236 18.9 µM -1.23281248124786 0.102655225293636 no 3021 0.10882286680681 955 5393171
SGTC_2751 anetholtrithion 17.25 µM -1.23702920682498 0.101884936317197 no 3022 0.108038119874565 987 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2552 juarezic acid 87.02 µM -1.24087381185461 0.101186298431612 no 3023 0.107326184224225 983 1549512
SGTC_2677 mitomycin C 100 µM -1.24152799073393 0.101067770063857 no 3024 0.107205382269415 1012 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2177 5811945 192 µM -1.24168801458548 0.101038791317075 no 3025 0.107175846881712 972 5343475
SGTC_1587 estradiol valerate 56.1 µM -1.24173056554933 0.101031086775149 no 3026 0.107167994295012 999 13791 A steroid.
SGTC_2359 9039622 200 µM -1.24559900053135 0.1003324319799 no 3027 0.106455824707176 992 6463596
SGTC_1743 st037606 46.3785 µM -1.25212515921572 0.0991617848282135 no 3028 0.105262130676656 970 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2869 9037858 32.47 µM -1.25320165874928 0.0989696485009972 no 3029 0.105066163227502 979 27187042
SGTC_2436 5633522 8.09 µM -1.25411396503867 0.0988070311153761 no 3030 0.104900292570612 994 5724242
SGTC_3264 9137442 49.47 µM -1.25598234366331 0.0984746055187318 no 3031 0.104561185837868 964 17015726
SGTC_1885 st057546 99.9 µM -1.25731866537642 0.0982373473304964 no 3032 0.104319133882923 948 702008
SGTC_801 0866-0028 10.1 µM -1.25892753703443 0.0979522549231243 no 3033 0.104028253234689 978 6849771
SGTC_887 0885-0007 9.62 µM -1.26337180285412 0.097167881696407 no 3034 0.103227796348692 1000 5719458
SGTC_614 0462-0418 107 µM -1.26364390872736 0.097120007619737 no 3035 0.103178933046506 964 5188303
SGTC_496 calpeptin 138 µM -1.26592911887681 0.0967186326971752 no 3036 0.102769230089196 977 73364 A calpain inhibitor.
SGTC_590 k048-0076 22.4 µM -1.2673288500445 0.0964733859377399 no 3037 0.102518864426984 1001 6832814
SGTC_2417 cerulenin 830 nM -1.27089571827685 0.0958505015492583 no 3038 0.101882874936043 980 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1140 3229-1848 2.98 µM -1.27155479210597 0.0957357316047594 no 3039 0.101765673959017 981 2849525
SGTC_2014 4013930 200 µM -1.27370146668075 0.0953626144712016 no 3040 0.101384618234798 994 64556
SGTC_3100 9120536 49.47 µM -1.27598757436615 0.094966440492828 no 3041 0.100979955779087 973 16421196
SGTC_1603 st002045 67.8 µM -1.27662389534284 0.0948563844410525 no 3042 0.100867530768215 991 5887985
SGTC_78 0336-0123 156.75 µM -1.27839443676573 0.0945506518063771 no 3043 0.100555192316155 974 6765896
SGTC_1114 scopoletin 1.73284 µM -1.27998766962352 0.0942761578898659 no 3044 0.100274736236571 1004 5280460 A coumarin with genotoxic properties.
SGTC_486 niguldipine 82 µM -1.28008416312101 0.0942595521743855 no 3045 0.100257768883062 986 1236 A calcium channel blocker.
SGTC_2078 5212016 200 µM -1.28023097235416 0.0942342916842453 no 3046 0.100231958063197 987 1899708
SGTC_513 4245-1575 41.7 µM -1.28126291899099 0.094056872371029 no 3047 0.100050666358529 966 719745
SGTC_133 0724-0033 378.92 µM -1.28167377410411 0.0939863039938693 no 3048 0.0999785542811334 979 280309
SGTC_1540 guanosine 70.6 µM -1.28467002740671 0.093472849310266 no 3049 0.0994538081776559 977 6802 Guanosine is a purine nucleoside
SGTC_863 0466-0191 129 µM -1.28699987595717 0.093075027545289 no 3050 0.0990471656871451 992 765160 YPR165W RHO1
SGTC_1648 st011736 69.8 µM -1.29106667339628 0.092383622596305 no 3051 0.0983402795304962 991 2855514
SGTC_2030 5175110 200 µM -1.29456907704429 0.0917912237791772 no 3052 0.0977344627796205 1009 2831986
SGTC_2228 7354201 200 µM -1.29518726497307 0.091686955892482 no 3053 0.0976278184535818 1011 753451
SGTC_235 0330-0087 5 mM -1.29601158055519 0.0915480576331476 no 3054 0.0974857475862998 1002 46494818 YHR062C RPP1
SGTC_548 1436-0017 110 µM -1.30628879025444 0.0898294062618036 no 3055 0.09572718386719 1001 9677137
SGTC_1686 st019653 115.5 µM -1.31189872332081 0.0889014377732841 no 3056 0.0947771541759978 1019 97252
SGTC_1623 st003709 20.3 µM -1.31248068705151 0.0888055821896216 no 3057 0.0946789990943976 981 16192618
SGTC_1412 3909-8563 178 µM -1.316897083196 0.0880806617414141 no 3058 0.0939365621698281 1003 23767530
SGTC_2651 TUB2.036 5 µM -1.31785328535008 0.0879242905132314 no 3059 0.0937763831352636 964 15992207 YFL037W TUB2
SGTC_1548 st061468 90.8 µM -1.31914930541975 0.0877126782106801 no 3060 0.093559601176913 999 390799
SGTC_2408 sulbentine 18.36 µM -1.32427199062495 0.086879971731009 no 3061 0.0927063646480495 963 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_698 k064-0052 127 µM -1.32770880982487 0.0863246269959681 no 3062 0.0921371610197073 1037 5088751
SGTC_1356 1502-0781 85.8 µM -1.32979851187852 0.0859882589149508 no 3063 0.0917923331937662 986 567702
SGTC_170 4197-0004 226 µM -1.33043033331393 0.0858867513634814 no 3064 0.0916882629485096 993 218692
SGTC_1 0258-0098 57.368 µM -1.33120290359743 0.0857627532014751 no 3065 0.0915611281363516 962 6790032 YDR047W HEM12
SGTC_1380 2291-0730 164 µM -1.33561202638625 0.085057649072853 no 3066 0.0908380585981108 1000 2999191
SGTC_482 fipronil 114 µM -1.34109727387172 0.0841865276696446 no 3067 0.0899444361521402 1006 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1539 benzyladenosine 56 µM -1.34212707518639 0.0840237324793426 no 3068 0.0897773981986581 974 92208 A nucleotide analog.
SGTC_2813 7971799 71.43 µM -1.34275206384404 0.0839250470449198 no 3069 0.0896761350072762 1003 2234054
SGTC_3121 9125696 49.47 µM -1.34329519829089 0.083839357063482 no 3070 0.089588203153176 1029 1235365
SGTC_3055 9094636 49.47 µM -1.34964944270537 0.0828417282550343 no 3071 0.0885642282876478 1000 25236176
SGTC_3342 9147791 14.508 µM -1.35141344924798 0.0825663660129886 no 3072 0.0882815139653752 985 1838168
SGTC_1656 st012921 11 µM -1.3521603355772 0.0824499845398982 no 3073 0.0881620146564129 995 6732821
SGTC_1190 1486-1332 13 µM -1.35297377158863 0.0823233737000782 no 3074 0.0880320048427069 991 4150046
SGTC_2206 7254556 146.969 µM -1.3534164653546 0.0822545302253042 no 3075 0.0879613100994698 994 4398905
SGTC_1183 1254-0324 198 µM -1.35440667604345 0.0821006991583039 no 3076 0.0878033344399168 987 5799357
SGTC_2414 st077232 92.9 µM -1.35921985099185 0.0813560492858008 no 3077 0.0870384663554986 989 729801
SGTC_2339 9000433 200 µM -1.36075814124004 0.08111913678657 no 3078 0.0867950670405649 988 2988954
SGTC_928 2764-0428 58.7 µM -1.36098035175657 0.0810849571624949 no 3079 0.0867599493811663 1008 662578
SGTC_1621 st003705 32.4 µM -1.36740417047696 0.0801015606634961 no 3080 0.0857493279280924 995 24207032
SGTC_1825 st052143 62.6 µM -1.36745841589205 0.0800932950128608 no 3081 0.0857408315006815 1005 674173
SGTC_3266 9136860 49.47 µM -1.36882587978497 0.0798851405072828 no 3082 0.0855268545725787 964 4871271 YPR165W RHO1
SGTC_2878 9043973 25.97 µM -1.37057069551215 0.079620140088029 no 3083 0.0852544116573055 1022 6465167
SGTC_81 0411-0046 9.971 µM -1.37100263435291 0.0795546405802732 no 3084 0.0851870674130392 986 12925265
SGTC_977 1348-1378 135 µM -1.37317515015159 0.0792258168925078 no 3085 0.0848489514895838 989 X977
SGTC_313 3474-0040 5.03 µM -1.37465884704539 0.0790018422402801 no 3086 0.0846186176479058 1013 1043375 YIL048W NEO1
SGTC_2649 anisomycin 9.56 µM -1.38011869571905 0.078181767482054 no 3087 0.0837750509089411 1011 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_681 1642-0006 26.6 µM -1.38017213105317 0.0781737734690458 no 3088 0.083766826281493 1033 4446530
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.38308053081179 0.0777396067087606 no 3089 0.0833200873287183 983 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.38655284770275 0.0772236582178914 no 3090 0.0827890774428814 1022 688798
SGTC_1365 1672-3266 55.4 µM -1.39023132247297 0.0766799192012306 no 3091 0.0822293224476609 981 6415873
SGTC_408 cantharidin 100 µM -1.39383862555126 0.07614953289757 no 3092 0.0816831706290212 1004 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1381 2324-0066 62.1 µM -1.3964475252042 0.0757676865285301 no 3093 0.0812898860547757 1016 10885928
SGTC_2478 5763493 32.33 µM -1.3975895097288 0.0756010018881099 no 3094 0.0811181851584108 988 1365576 YLR208W SEC13
SGTC_228 caffeine 993.056 µM -1.40193159661815 0.0749697786580834 no 3095 0.0804678370448131 1001 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1029 k015-0030 64.7 µM -1.40646194115993 0.0743154812407923 no 3096 0.079793499166584 997 2208316
SGTC_2884 9058502 51.95 µM -1.40747007894845 0.0741704753092882 no 3097 0.0796440218032111 1004 6471554
SGTC_213 1246-0773 967 nM -1.40831657327386 0.0740488864309593 no 3098 0.0795186751424121 1006 6251622
SGTC_3236 9132701 49.47 µM -1.40993329696335 0.0738170864612037 no 3099 0.0792796898530519 1028 24282524
SGTC_82 0054-0107 293.755 µM -1.41271786900836 0.0734191453663274 no 3100 0.0788693477075481 1008 3104697
SGTC_2818 7996756 12.99 µM -1.41371381544371 0.0732772144615818 no 3101 0.0787229736364272 1029 2241621
SGTC_1277 0873-0036 22 µM -1.41454030650575 0.0731595918453325 no 3102 0.0786016607646024 1013 5965735
SGTC_1188 1403-0014 4.57 µM -1.416264455589 0.0729146835368139 no 3103 0.0783490452661802 990 9614867
SGTC_1142 3253-1408 9.78 µM -1.41687654187693 0.0728278902977054 no 3104 0.0782595130283644 1025 256655
SGTC_3344 9148862 3.898 µM -1.41996955808044 0.0723905128878289 no 3105 0.0778082718738611 1029 4905352
SGTC_2681 menadione 3.18 µM -1.42237045600323 0.0720523962116398 no 3106 0.0774593675649462 1016 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_543 3844-1095 191 µM -1.42262322903124 0.0720168689341269 no 3107 0.0774227032183805 1007 4230703
SGTC_2119 5528445 120.635 µM -1.42533923518567 0.0716359809499662 no 3108 0.077029581899904 1027 791935
SGTC_514 4466-0038 2.65 nM -1.42558397732439 0.0716017347890432 no 3109 0.0769942319761593 961 5722064
SGTC_2872 9044037 25.97 µM -1.42922892770215 0.0710931913008699 no 3110 0.0764692229362361 1026 6465195
SGTC_387 norethindrone acetate 66.7 µM -1.43097735300583 0.0708502374684028 no 3111 0.0762183529205347 1035 541197
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.43104100427337 0.0708414048040127 no 3112 0.0762092318509952 1044 4620898
SGTC_712 r015-0009 80.6 µM -1.43159265126104 0.070764890108854 no 3113 0.0761302169957405 1027 6813872 YLR060W FRS1
SGTC_193 1273-0060 1.558 µM -1.44376149788425 0.0690931466006664 no 3114 0.0744030379043955 1009 2847393 YHR072W ERG7
SGTC_1477 0139-0234 16 µM -1.44404959081907 0.0690539407105896 no 3115 0.0743625131511577 1031 620880
SGTC_2885 9057732 51.95 µM -1.44982870446546 0.0682710912402995 no 3116 0.0735531464093027 1009 6471414
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.45135833146805 0.0680650358002357 no 3117 0.0733400531317208 1014 5377381
SGTC_2569 tetrandrine 100 µM -1.4555255440399 0.0675061079065557 no 3118 0.0727619119014617 1002 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2026 5148700 152 µM -1.45698052696859 0.0673117957224406 no 3119 0.0725608777984051 1019 79838
SGTC_2019 4016004 108 µM -1.45792869667283 0.0671854010467451 no 3120 0.0724300989083102 1008 45595336
SGTC_2284 7945075 39.21 µM -1.4593946728059 0.0669903420824799 no 3121 0.0722282556969723 998 1245402
SGTC_597 k018-0003 82.8 µM -1.46097101998834 0.0667810864784282 no 3122 0.0720116973199024 1034 6786234
SGTC_1513 0337-0559 19 µM -1.46312880724616 0.0664954668002676 no 3123 0.0717160683256222 1016 775073
SGTC_2440 5628896 157.78 µM -1.46575721746822 0.0661488308344587 no 3124 0.0713572200774264 1025 5522048
SGTC_1234 0326-0494 15.5 µM -1.46596275561412 0.0661217834866845 no 3125 0.0713292168334358 1012 1547813
SGTC_3097 9117246 49.47 µM -1.46908233697146 0.065712319923897 no 3126 0.0709052289771013 1013 16423892
SGTC_1791 st048313 56.1 µM -1.46969693601093 0.065631882423415 no 3127 0.0708219264721668 992 1204976
SGTC_1211 1056-0033 32.3 µM -1.47245969490514 0.0652712405969564 no 3128 0.0704483916655254 997 6741922
SGTC_3227 9130768 49.47 µM -1.47348853692584 0.0651373323643853 no 3129 0.0703096762668886 1053 17720899
SGTC_3226 9131256 49.47 µM -1.474477424241 0.0650088254314272 no 3130 0.0701765458816654 994 17178073
SGTC_894 0960-0238 55.9 µM -1.4744977183708 0.0650061902503282 no 3131 0.0701738157868499 1024 6741907 YDL195W SEC31
SGTC_960 1222-0186 7.7 µM -1.48050711497415 0.0642295144868088 no 3132 0.0693689816822426 1023 3126296
SGTC_2514 salinomycin 42.74 µM -1.48332614263776 0.0638676676045455 no 3133 0.068993889910824 1028 23682228 A polyether potassium ionophore.
SGTC_557 1315-0110 16.2 µM -1.48736947233194 0.0633514411226694 no 3134 0.0684586275358918 1013 6833801
SGTC_1990 st072050 59.8 µM -1.48737139510036 0.0633511964108896 no 3135 0.0684583737610619 1023 17233948
SGTC_1985 st071382 65.5 µM -1.48804850939455 0.0632650654557175 no 3136 0.0683690505727127 1042 6123237
SGTC_2521 angolensin 13.4 µM -1.48904931406495 0.0631379271222058 no 3137 0.0682371916990097 1011 821428 A flavenoid.
SGTC_1178 0988-0033 191 µM -1.49002995284703 0.0630135436689527 no 3138 0.0681081802008286 1008 5392207
SGTC_587 k089-0003 57 µM -1.49295560244946 0.0626435905499108 no 3139 0.0677244044606859 996 9659696
SGTC_2568 diosmetin 100 µM -1.49497347871545 0.0623894148843937 no 3140 0.0674606819286536 1018 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1716 st033144 30.6155 µM -1.49835247935513 0.0619655910423613 no 3141 0.067020847966777 1026 674617
SGTC_2217 6934799 96.0675 µM -1.49968643787936 0.0617988941702799 no 3142 0.0668478226323913 1026 675606
SGTC_295 k015-0027 31 µM -1.50221660074422 0.0614836766241405 no 3143 0.0665205894468364 1029 3887424
SGTC_2846 9008642 19.48 µM -1.50230308175486 0.0614729247192622 no 3144 0.0665094265665756 1041 2992898
SGTC_2907 7721985 69.9 µM -1.5067687507052 0.0609197157621835 no 3145 0.0659349710536359 1030 3267881
SGTC_895 0964-0006 13.7 µM -1.50725733366502 0.0608594268743307 no 3146 0.0658723546922807 1026 6738897
SGTC_1031 k035-0009 16 µM -1.50982118024939 0.0605438244109895 no 3147 0.0655445295206163 1024 5180959
SGTC_1699 st031318 29.054 µM -1.51578498117874 0.0598146505848937 no 3148 0.0647868654623511 1020 5340658
SGTC_825 1988-2224 89.6 µM -1.51580208938167 0.0598125687628157 no 3149 0.064784701795285 1023 1180859
SGTC_1121 fusaric acid 630.51 nM -1.52102501718337 0.0591796630580111 no 3150 0.0641267797207569 1022 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2821 7996764 71.43 µM -1.52360162224479 0.0588693750413855 no 3151 0.0638041288467328 991 2987135
SGTC_1048 3161-0300 24.5 µM -1.52918590089569 0.0582012699442129 no 3152 0.0631091824038904 1014 2165101
SGTC_420 mitomycin C 81.9 mM -1.5396128823052 0.0569697419679961 no 3153 0.061827371728339 1003 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_263 alizarin 107.927 µM -1.54594437024487 0.0562320025135896 no 3154 0.0610590017372734 1028 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2480 5767542 37.17 µM -1.54754477646739 0.0560467222781835 no 3155 0.0608659679971597 1015 2867358
SGTC_2456 5770359 74.46 µM -1.55288507127283 0.0554319542937815 no 3156 0.0602252969639296 1025 3118787
SGTC_1208 2323-2347 50.3 µM -1.56072135609243 0.0545395039516047 no 3157 0.0592947550568192 1029 5412760
SGTC_1325 1431-0015 227 µM -1.56637161218644 0.0539030930933731 no 3158 0.058630822393287 1030 1103340
SGTC_2287 7945887 168.79 µM -1.5823564371557 0.0521344707477678 no 3159 0.0567841117973572 1026 1245853
SGTC_1619 st003326 88.7 µM -1.58517524254555 0.051827422573032 no 3160 0.056463261932827 977 2849032
SGTC_3005 9076496 71.4286 µM -1.590258078459 0.0512773908599013 no 3161 0.0558883219587721 1026 21368410
SGTC_926 2268-1401 59.4 µM -1.59243311022676 0.0510434462673914 no 3162 0.0556437107816267 1039 2931578
SGTC_1065 prochlorperazine maleate 2.48 µM -1.5931462962269 0.0509669217846087 no 3163 0.0555636877701981 1047 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1061 3448-9325 110 µM -1.5987362963095 0.0503702763882423 no 3164 0.0549396045336437 1028 723482
SGTC_2822 7994718 71.43 µM -1.60003584874574 0.0502323699125779 no 3165 0.0547953154407949 1058 1018011
SGTC_2528 xanthyletin 44.79 µM -1.60454960331067 0.0497557139527766 no 3166 0.0542964799361868 1032 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1714 st033236 13.627 µM -1.60629520882869 0.0495723470460912 no 3167 0.0541045312854287 1022 2916566
SGTC_3312 9133330 71.43 µM -1.60814491635343 0.0493786336757773 no 3168 0.0539017219428642 1047 17617324
SGTC_994 3910-0338 138 µM -1.61230332690081 0.0489453443302278 no 3169 0.0534479748612748 1035 3479481
SGTC_362 0310-0100 9.03 µM -1.61271188534253 0.048902938613556 no 3170 0.0534035585818353 1039 790235
SGTC_476 mead acid 10 µM -1.62205044910933 0.0479416362919943 no 3171 0.05239627328565 1056 5312531 An omega 9 fatty acid.
SGTC_1214 0358-0031 63.7 µM -1.62205770921578 0.047940894871572 no 3172 0.0523954960982394 1050 4301366
SGTC_624 k048-0052 28 µM -1.62256125834286 0.0478894935525719 no 3173 0.0523416139763775 1044 6835531
SGTC_2271 7849410 118.62 µM -1.62416453673687 0.0477261278145613 no 3174 0.052170348661764 1044 972430
SGTC_3038 9091290 49.47 µM -1.62788952909684 0.0473482931983861 no 3175 0.0517741560282839 1028 25236843
SGTC_2947 9072639 7.68 µM -1.66052349709545 0.0441397151262848 no 3176 0.048404592470247 1053 16488146
SGTC_2575 plumbagin 510 nM -1.66170964441422 0.0440264787349113 no 3177 0.0482855032186068 1028 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2133 5320837 200 µM -1.66386488892425 0.043821326380293 no 3178 0.0480697164971741 1053 2841355
SGTC_1282 0886-0010 32.4 µM -1.67745851190317 0.0425450920932737 no 3179 0.0467264279022686 1018 2836211 YNL267W PIK1
SGTC_924 2046-0044 21.3 µM -1.67786943062585 0.042506986143396 no 3180 0.0466862957137219 1034 3623589
SGTC_1898 st060199 18.6 µM -1.67907861362725 0.0423950144059841 no 3181 0.0465683618180745 1023 688866
SGTC_714 4296-0578 26.1 µM -1.6794747191286 0.0423583865024979 no 3182 0.0465297809305917 1049 1589775
SGTC_572 0960-0087 17.7 µM -1.68151264197426 0.0421703440991946 no 3183 0.0463316914932508 1049 6796365
SGTC_599 1935-0052 86.5 µM -1.68806040139766 0.0415707396701566 no 3184 0.0456998174114908 1049 9557311
SGTC_3239 9133757 49.47 µM -1.69076174574658 0.0413253879307183 no 3185 0.0454411580529961 1071 17036923
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.69370152355599 0.0410597153555255 no 3186 0.0451610074104251 1049 97141
SGTC_1630 st005209 31.3 µM -1.69472982265029 0.0409671138928702 no 3187 0.0450633427745385 1013 3367314
SGTC_2166 5933061 31.504 µM -1.69483933351343 0.0409572620949008 no 3188 0.0450529517975142 1052 2877375
SGTC_52 0329-0193 875 nM -1.70493905445645 0.0400569014092194 no 3189 0.0441028957928797 1033 3739292
SGTC_1657 st012939 43.4 µM -1.70825711714575 0.0397646396096929 no 3190 0.0437943222525848 1046 24207257
SGTC_1809 st050081 57.6 µM -1.71209333889248 0.0394289006686096 no 3191 0.0434397343658009 1043 5036894
SGTC_1213 1315-0166 115 µM -1.71379768150535 0.0392804814755069 no 3192 0.0432829446854742 1034 768401
SGTC_1799 st045822 46.1415 µM -1.71745592649111 0.0389634457666956 no 3193 0.0429479503292948 1008 3674992
SGTC_484 loperamide 105 µM -1.7189983063828 0.0388304038884144 no 3194 0.0428073401556946 1058 3955 An opioid-receptor agonist.
SGTC_582 0987-0078 156 µM -1.71994322504724 0.0387490804735627 no 3195 0.0427213811472242 1049 1625765
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.72126551404747 0.0386355120614927 no 3196 0.0426013271622709 1021 5379071
SGTC_1131 3454-3128 32.3 µM -1.73159145601712 0.0377579393814121 no 3197 0.0416731642639297 1025 710982
SGTC_1429 4049-0205 9.46 µM -1.73273785896511 0.0376615212949247 no 3198 0.0415711361069473 1043 22774478
SGTC_2458 5808907 16.39 µM -1.73765852127168 0.0372499499762074 no 3199 0.0411355007606791 1050 2731747
SGTC_2170 morpholine 200 µM -1.74213190652083 0.036878985460265 no 3200 0.040742682836664 1054 121171 Reacts with secondary amines.
SGTC_2180 6301957 200 µM -1.75041195741389 0.0362003172022908 no 3201 0.0400236270923783 1039 845462
SGTC_2267 7931562 200 µM -1.75329235675688 0.0359666382193017 no 3202 0.0397759184029905 1048 934880
SGTC_2516 gossypol 71.55 µM -1.75355522364797 0.0359453742079531 no 3203 0.0397533745650793 1053 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2685 mycophenolic acid 18.85 µM -1.75441121516826 0.0358762021038568 no 3204 0.0396800354986582 1034 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_930 2810-3379 265 µM -1.75646605041404 0.0357105972793732 no 3205 0.0395044316869721 1055 1015764
SGTC_108 0509-0257 621.132 µM -1.76049697137941 0.0353875541512305 no 3206 0.0391617902841632 1049 536624
SGTC_1056 3448-1962 115 µM -1.76435212971389 0.0350808427279491 no 3207 0.038836356185102 1029 715507
SGTC_628 1636-0253 16 µM -1.77255677523019 0.0344353508059207 no 3208 0.0381510897918962 1032 4456143
SGTC_2128 5255449 168.493 µM -1.7769454108223 0.0340941054277699 no 3209 0.0377886109412422 1026 736008
SGTC_1320 1313-0481 95.3 µM -1.77804095561293 0.0340093546636213 no 3210 0.0376985643145255 1049 6813365 YLR208W SEC13
SGTC_1881 5652484 16 µM -1.78252366884446 0.0336643772551716 no 3211 0.0373319374907803 1051 2255129
SGTC_2768 sulfasalazine 50.2 µM -1.7869686719327 0.0333251506013536 no 3212 0.0369712760568155 1055 5384001 An antioxidant and salicylic acid derivative.
SGTC_2489 cantharidin 73.42 µM -1.79123462349313 0.0330022406710121 no 3213 0.0366278261302347 1044 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_759 3486-0358 89.3 µM -1.79166172549254 0.0329700537932032 no 3214 0.0365935845376763 1067 875103
SGTC_2291 7917025 104.35 µM -1.79664508833291 0.0325964104674459 no 3215 0.0361959907896465 1044 2964612
SGTC_156 3474-0145 5.642 µM -1.81446937200233 0.0312884574016798 no 3216 0.0348027469767426 1038 2265471
SGTC_678 1218-2179 85.9 µM -1.81467305335935 0.0312737657767708 no 3217 0.0347870842479916 1068 6820081 YOR116C RPO31
SGTC_1486 3970-0793 4.53 µM -1.81650028480763 0.0311422217793868 no 3218 0.0346468321448042 1058 2844330
SGTC_2266 7929956 200 µM -1.81825127116933 0.0310165965308473 no 3219 0.0345128684344314 1052 2967153
SGTC_1156 4092-0367 4.88 µM -1.82502774390742 0.0305343611145677 no 3220 0.0339984213737035 1049 1357585
SGTC_469 w7 172 µM -1.82768083419214 0.0303472581830956 no 3221 0.0337987330954425 1066 45115570 A P450 inhibitor.
SGTC_58 0957-0393 9 µM -1.82860227796477 0.0302824982219016 no 3222 0.0337296056018296 1048 6997992
SGTC_1801 st050089 28.441 µM -1.8301610651787 0.0301732059189746 no 3223 0.033612928952813 1053 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1907 st060210 83.7 µM -1.83725675715398 0.0296798247698941 no 3224 0.0330860001963905 1050 688793
SGTC_2264 7948757 110.76 µM -1.83781882844524 0.0296410303723191 no 3225 0.033044553108518 1058 2971411
SGTC_2794 7785382 27.27 µM -1.84369881498534 0.0292377083714226 no 3226 0.0326135229162057 1026 2205081
SGTC_1784 st039334 36.3 µM -1.84591944485179 0.0290865807584673 no 3227 0.0324519514183409 1048 3496984
SGTC_2764 methyldopa 94.69 µM -1.86460369357381 0.0278405322667549 no 3228 0.031118487380194 1060 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_128 0906-2981 13.371 µM -1.87086232860873 0.0274332193293647 no 3229 0.0306820828553073 1057 6740226
SGTC_298 1391-0729 10 µM -1.88463920898505 0.026554105331974 no 3230 0.0297392824517745 1064 3237558
SGTC_1695 st026914 34.495 µM -1.88472531587942 0.0265486856793775 no 3231 0.0297334663087313 1072 3289191
SGTC_2788 5282734 71.43 µM -1.88985783195226 0.0262273053209974 no 3232 0.0293884882501432 1050 743706
SGTC_802 4112-3352 742 µM -1.88997360727398 0.0262200935512158 no 3233 0.0293807449948027 1047 704594
SGTC_1301 naphtanilide LB 4.81 µM -1.90153993989922 0.0255079248622119 no 3234 0.0286156631227985 1046 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1913 st060213 96.1 µM -1.90185653274334 0.0254886614674693 no 3235 0.0285949565757747 1056 688959
SGTC_260 nsc-65238 3.989 µM -1.90422563988438 0.0253448972216555 no 3236 0.0284404019156187 1069 3246252
SGTC_1729 st035615 45.989 µM -1.90721565477408 0.0251644247677878 no 3237 0.0282463335493313 1039 17385451
SGTC_898 1000-0849 28.3 µM -1.91185217978136 0.0248867022313056 no 3238 0.0279475783847675 1060 6751807
SGTC_2448 5185112 27.17 µM -1.91211700318379 0.0248709175167186 no 3239 0.0279305942079793 1055 5718189
SGTC_2824 7998404 51.95 µM -1.91385808451018 0.0247673498417654 no 3240 0.0278191456877403 1057 837851
SGTC_2723 salbutamol 83.58 µM -1.91481743663618 0.0247104378320419 no 3241 0.0277578949909157 1048 9884233 β2-adrenoceptor agonist
SGTC_1135 dihydrocapsaicin 536.708 nM -1.92078299463447 0.0243589978186241 no 3242 0.0273795356127886 1058 107982 A Capsaicinoid.
SGTC_3148 9097893 49.47 µM -1.92935308323105 0.0238614730879765 no 3243 0.0268435219667617 1041 17174100
SGTC_1815 st051655 58.2 µM -1.93773462572607 0.0233831837731623 no 3244 0.0263278036031993 1051 5984156
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.94712689008067 0.0228568290579303 no 3245 0.0257597619647547 1040 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2560 caryophyllene 100 µM -1.95521036891931 0.0224118470732704 no 3246 0.0252791226097906 1073 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_83 0170-0301 39.027 µM -1.95846254293263 0.0222348928986602 no 3247 0.0250878810700929 1073 3089716
SGTC_1715 st032160 10.2275 µM -1.96060499913387 0.0221189649021002 no 3248 0.0249625593843571 1054 5289825
SGTC_3335 9143315 29.6265 µM -1.96695177156979 0.021778531871813 no 3249 0.0245943855610954 1052 4899691
SGTC_40 0327-0103 19.753 µM -1.96994245259944 0.021619655899166 no 3250 0.0244224831512487 1035 409036
SGTC_533 1222-0222 6.71 µM -1.9755309067587 0.0213254009700534 no 3251 0.0241039653968924 1067 3982874
SGTC_1856 st057054 55.7 µM -1.98043982459686 0.0210697272225174 no 3252 0.0238270643711461 1054 1266018
SGTC_586 0957-0265 8.15 µM -1.99562140664872 0.0202953727108488 no 3253 0.022987573822131 1035 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3233 9132340 49.47 µM -2.00005089264813 0.0200740397311563 no 3254 0.0227473843447545 1073 17682950
SGTC_2429 5902844 64.44 µM -2.00239583475906 0.0199576985460337 no 3255 0.0226210880522879 1065 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2972 9093619 59.92 µM -2.00437390131475 0.0198600046977572 no 3256 0.022515011433374 1043 25236256
SGTC_2800 7887935 81.82 µM -2.00560267987211 0.0197995216887309 no 3257 0.0224493278812306 1074 2961002
SGTC_1992 st073643 23.3 µM -2.00687474259872 0.0197370729145242 no 3258 0.0223815009152925 1077 3161292
SGTC_1392 3455-1037 33.9 µM -2.00951286583405 0.0196080935962338 no 3259 0.0222413858168943 1058 981132
SGTC_29 0299-0004 12.984 µM -2.02307049402565 0.0189564890101852 no 3260 0.0215329400509293 1068 16871 A napthoquinone isolated from Swertia calycina.
SGTC_627 1391-0720 175 µM -2.03520395864643 0.0183890399567851 no 3261 0.0209151774560557 1075 997839
SGTC_3143 9086658 49.47 µM -2.03830079455201 0.0182465489696543 no 3262 0.02075993023875 1041 25236626
SGTC_845 0330-0138 4.51 µM -2.04147119363963 0.0181016488917622 no 3263 0.0206020071538055 1060 9039800
SGTC_1889 st059080 5.18 µM -2.04821860085864 0.0177965275873861 no 3264 0.0202692923196295 1067 176925 Isolated from Daphnopsis sellowiana.
SGTC_95 0471-0001 561.058 µM -2.07241583299147 0.0167381375438008 no 3265 0.0191133390321699 1076 4015405
SGTC_1911 st060208 74.3 µM -2.0767764359582 0.0165532450920155 no 3266 0.0189110990251283 1066 688783
SGTC_929 2805-0021 398 µM -2.08584120063859 0.0161744809256559 no 3267 0.0184965049790461 1076 3098024
SGTC_757 1066-0008 322 µM -2.09159399590744 0.0159379763245018 no 3268 0.0182374250422071 1053 6842497
SGTC_661 1304-0007 33.6 µM -2.09268253793614 0.0158935601656739 no 3269 0.018188751536029 1077 3117130
SGTC_3036 9090181 49.47 µM -2.0948056473601 0.0158072355022658 no 3270 0.0180941364493401 1078 25236586
SGTC_3201 9113999 49.47 µM -2.09538395344745 0.0157837916376517 no 3271 0.0180684374078761 1058 16649224
SGTC_360 0957-0399 1.01 µM -2.1052266312766 0.0153893304718359 no 3272 0.0176357925653934 1067 6752301 YPR165W RHO1
SGTC_2696 st077691 74.316 µM -2.1069552655472 0.0153209337185057 no 3273 0.0175607286999952 1066 757133
SGTC_536 3852-0578 10.6 µM -2.10791200792083 0.0152831907059747 no 3274 0.0175193006791219 1071 2869208
SGTC_2812 7970281 58.44 µM -2.1085010568172 0.015259992759948 no 3275 0.0174938357208635 1071 2233435
SGTC_2537 larixol 68.93 µM -2.11163640703641 0.0151370245537648 no 3276 0.0173588236735709 1070 6708759
SGTC_521 r062-0005 13.8 µM -2.11382558303675 0.0150516708526174 no 3277 0.0172650835298011 1071 2832033
SGTC_2124 5246320 200 µM -2.1242170452212 0.014652137625012 no 3278 0.016825999279172 1065 579342
SGTC_2003 4023581 200 µM -2.12727047209995 0.0145364872719811 no 3279 0.0166988083450564 1060 16641307
SGTC_713 1488-1073 324 µM -2.160840812105 0.0133159263075217 no 3280 0.0153538191302202 1080 3312542
SGTC_2582 agaric acid 100 µM -2.16897984619345 0.0130336986986858 no 3281 0.0150421070113373 1058 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_229 benomyl 22.8748 µM -2.17012582183251 0.0129943793174473 no 3282 0.0149986577626761 1072 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1000 4048-0884 8.67 µM -2.17474299452598 0.0128369974531105 no 3283 0.0148246905293319 1075 13040088
SGTC_701 4424-0219 185 µM -2.17974714335485 0.0126682894669531 no 3284 0.0146381049624516 1073 2911779
SGTC_2147 5545932 89.7195 µM -2.19937787212508 0.0120248623305468 no 3285 0.0139255323552431 1083 797404
SGTC_2572 astragaloside iv 100 µM -2.21129091011442 0.0116483711864482 no 3286 0.01350784920425 1064 45006101 An anti-inflammatory agent.
SGTC_2159 5658611 73.75 µM -2.2210774753456 0.0113467820451983 no 3287 0.0131728571819615 1071 793844
SGTC_2132 5317594 122.667 µM -2.27850291361752 0.0097102784730912 no 3288 0.0113483155521637 1078 794577
SGTC_127 0180-0333 59.125 µM -2.27946581535499 0.00968469466059453 no 3289 0.0113196949123121 1042 771601
SGTC_1321 1326-2144 215 µM -2.28427342514887 0.00955783815991385 no 3290 0.0111777333473641 1078 3513030
SGTC_1165 k072-0275 30.3 µM -2.30687491952313 0.00898073490656401 no 3291 0.0105308970428562 1076 6153523 YGL055W OLE1
SGTC_3341 9147222 25.867 µM -2.31624337761034 0.00875061733303637 no 3292 0.0102724919955322 1071 1939759
SGTC_783 0848-0141 92.7 µM -2.33896778728214 0.00821379240377794 no 3293 0.00966855034680973 1081 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_534 k292-0788 63.4 µM -2.34608843460485 0.00805164045358161 no 3294 0.00948580276099178 1087 4146317
SGTC_596 1155-0152 116 µM -2.37373307199177 0.00744847685030896 no 3295 0.0088046377308797 1082 280313
SGTC_2126 5251174 33.877 µM -2.37767969254627 0.00736569805076373 no 3296 0.00871097606320703 1079 790722
SGTC_2546 rhodinyl acetate 100 µM -2.38482357568737 0.00721791832547741 no 3297 0.00854365684227847 1069 6708682
SGTC_3015 9080845 49.47 µM -2.38704803734744 0.00717243964356157 no 3298 0.00849213592877415 1085 5296973
SGTC_2833 9001315 45.46 µM -2.39277564389937 0.0070565011425141 no 3299 0.00836073126190997 1067 2989378
SGTC_719 2810-4230 27.3 µM -2.40506229668277 0.00681335836981357 no 3300 0.00808485454885316 1089 721079
SGTC_2883 9059145 45.46 µM -2.42783193034547 0.00638226749741832 no 3301 0.00759469019829815 1083 16476510
SGTC_1009 4106-0057 9.87 µM -2.42813839887915 0.00637663372222374 no 3302 0.00758827531636606 1080 2928005
SGTC_2798 7813637 45.45 µM -2.42827755005419 0.00637407717563908 no 3303 0.00758536423265995 1076 956368
SGTC_1905 st060207 84.5 µM -2.44119274322067 0.00614070728371872 no 3304 0.00731941970061588 1075 1948547
SGTC_1620 st003704 16.5 µM -2.47000731797276 0.00564713390735969 no 3305 0.00675551440864138 1079 2834414
SGTC_1386 3228-0095 33.8 µM -2.48276649185359 0.00544006610482543 no 3306 0.0065183257051914 1076 870181
SGTC_248 streptozotocin 5.23457 mM -2.50736820169553 0.00505977024682596 no 3307 0.00608169667755754 1084 5300 DNA alkylating agent.
SGTC_591 4299-0174 154 µM -2.51047464228314 0.00501347400383961 no 3308 0.00602844905861111 1088 5509088
SGTC_615 k087-0205 167 µM -2.51988411327083 0.00487553539289599 no 3309 0.00586967384089924 1080 9642773
SGTC_2438 5259590 200 µM -2.52556646278288 0.00479388231560526 no 3310 0.00577559649084373 1078 1201127
SGTC_2938 9059746 27.26 µM -2.52938262973367 0.00473973212049958 no 3311 0.00571316918788357 1077 6471769
SGTC_374 0880-0231 82.3 µM -2.54865106131903 0.00447456400664302 no 3312 0.00540702205383977 1058 6833587
SGTC_1906 st060206 94.7 µM -2.55131313411774 0.00443899034123241 no 3313 0.0053658928227211 1074 5133468
SGTC_1348 1493-0373 93.8 µM -2.56435822278987 0.00426829353688956 no 3314 0.00516833998488863 1087 3010129
SGTC_2098 5376439 882.5 nM -2.57285006330262 0.00416035423520112 no 3315 0.0050432447025356 1083 2844116
SGTC_1391 3442-0225 151 µM -2.57861352354447 0.00408849302341997 no 3316 0.00495988496419913 1085 5227075
SGTC_2762 leflunomide 42.06 µM -2.59860614365935 0.0038477488225926 no 3317 0.00468015507315991 1092 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1185 1319-0113 81.3 µM -2.62088097130221 0.00359455182974645 no 3318 0.00438514385386832 1089 4672763
SGTC_2817 7995342 71.43 µM -2.63888642308785 0.00340092598794171 no 3319 0.00415894214462108 1077 18879975
SGTC_488 nitrendipine 139 µM -2.64024127474029 0.0033867425956122 no 3320 0.00414235114241417 1094 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_224 benfluorex 43.875 µM -2.65058092211756 0.00328024016406499 no 3321 0.0040176737811743 1092 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2871 9038510 12.99 µM -2.67402851209646 0.00304979991761692 no 3322 0.00374730396498104 1085 4945164
SGTC_804 1595-0054 20.9 µM -2.67883426670633 0.00300441009597703 no 3323 0.00369394754740263 1086 761523 Stimulates phospholipase C.
SGTC_51 1013-0126 23.419 µM -2.69094288283345 0.00289273225583556 no 3324 0.00356251962000885 1080 1627850
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.70221738682286 0.00279212719937959 no 3325 0.00344393561140905 1088 688803
SGTC_2087 5276107 200 µM -2.70813592788616 0.00274058818570975 no 3326 0.0033831151925008 1091 144405
SGTC_2092 5303694 80.6725 µM -2.73032764708699 0.00255489951194068 no 3327 0.00316357037326477 1090 1963699
SGTC_2767 sibutramine 71.45 µM -2.76925727172006 0.00225643135679233 no 3328 0.00280921253717624 1087 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1692 fluoroquinolonic acid 71 µM -2.77071822409664 0.00224587206911738 no 3329 0.00279664031472178 1085 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2279 7948423 32.93 µM -2.77113816734394 0.00224284515120597 no 3330 0.00279303589944543 1083 1247112
SGTC_2160 5660466 132.927 µM -2.79320375748557 0.00208890388097773 no 3331 0.00260944034970036 1088 2859134
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.80792939842882 0.00199157102017096 no 3332 0.0024930578414774 1084 115019
SGTC_2001 4023502 57.655 µM -2.81563187471467 0.00194231688825431 no 3333 0.00243407063882191 1084 108941 YCR052W RSC6
SGTC_623 k072-0108 16.9 µM -2.8626453040864 0.00166492908408857 no 3334 0.0021006028877061 1083 5382803
SGTC_2276 7947513 42.08 µM -2.87744105335073 0.00158540684115232 no 3335 0.00200457402869158 1085 2105100
SGTC_774 k060-0086 136 µM -2.88831309394405 0.00152919690937704 no 3336 0.0019365706730272 1091 5911235
SGTC_1920 st075728 45.7 µM -2.89213099411271 0.00150989311641412 no 3337 0.00191319186300827 1084 3400306
SGTC_99 0109-0120 622.8 µM -2.93792108176932 0.0012950753513588 no 3338 0.00165210560936829 1085 759414
SGTC_2703 st077852 53.4 µM -3.09763281965585 0.000746214978140075 yes 3339 0.00097536479927517 1087 6281836
SGTC_3346 9158254 43.5805 µM -3.12447525217123 0.000678514298516335 yes 3340 0.000890612523416439 1094 17639500
SGTC_1928 4'-methoxychalcone 40.3 µM -3.16812850502438 0.00058040355034828 yes 3341 0.000767118443363138 1084 641818
SGTC_2704 st078022 71.1 µM -3.30791656225607 0.000347577271160942 yes 3342 0.00046996404537757 1092 54697681
SGTC_2715 st079500 56.4 µM -3.35551379176782 0.000290617658101355 yes 3343 0.000396088532107246 1090 28246688
SGTC_2072 5231554 129 µM -3.37474015531393 0.00027017720191454 yes 3344 0.000369427089733899 1091 789545
SGTC_3189 9110682 49.47 µM -3.38354329440058 0.000261272426481384 yes 3345 0.000357784622742591 1089 17122418
SGTC_386 1509-0011 3.07 µM -3.38537400411797 0.000259455274620597 yes 3346 0.000355406665668548 1092 3107280
SGTC_877 0771-0151 33.1 µM -3.46697932867166 0.000189447101432145 yes 3347 0.000263171182845915 1095 6166523
SGTC_3192 9110362 49.47 µM -3.53889202696686 0.000142810911498702 yes 3348 0.000200905083169525 1092 16649480
SGTC_963 1269-2853 151 µM -3.70637373994533 7.24926305688894e-05 yes 3349 0.000105123987571728 1093 3668223
SGTC_2760 etidronate 98.04 µM -3.71722830552917 6.9309255697609e-05 yes 3350 0.000100710205923578 1092 3305 A chelator and antioxidant.
SGTC_1025 k007-0731 70 µM -3.8223282903374 4.45983345150734e-05 yes 3351 6.60987648693768e-05 1094 6256118
SGTC_351 caspofungin 25 nM -3.9351209213888 2.74476233147776e-05 yes 3352 4.15774092054739e-05 1095 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1014 4130-3005 69.3 µM -4.41551779477487 3.01019103181466e-06 yes 3353 5.03842447640463e-06 1095 743608
SGTC_1725 st036284 20.55 µM -4.45738812380565 2.4555767749543e-06 yes 3354 4.14821552872595e-06 1093 707914
SGTC_2099 5377090 177.372 µM -5.28756417140266 3.00250228595317e-08 yes 3355 6.19779410929636e-08 1095 2243829
SGTC_116 0155-0182 31.788 µM -9.49120186182208 1.2005959361417e-22 yes 3356 1.14192828878691e-21 1091 771486